bluuebunny/crossref_metadata_2025_split huggingface dataset:
ORal anticoagulants In fraGile patients with percutAneous endoscopic gastrostoMy and atrIal fibrillation: the (ORIGAMI) study
Authors: D’Amario Domenico , Galli Mattia , Canonico Francesco , Restivo Attilio , Arcudi Alessandra , Scacciavillani Roberto , Cappannoli Luigi , Riccioni Maria Elena , Annetta Maria Giuseppina , Di Stefano Gaetano , Piccinni Carlo , Vergallo Rocco , Montone Rocco Antonio , Leone Antonio Maria , Niccoli Giampaolo , Sabatelli Mario , Antonelli Massimo , Andreotti Felicita , De Cristofaro Raimondo , Crea Filippo 
Published: November 2020

Aims
The ORal anticoagulants In fraGile patients with percutAneous endoscopic gastrostoMy and atrIal fibrillation (ORIGAMI) study investigates the safety and efficacy of Edoxaban administered via PEG in patients with atrial fibrillation and a clinical indication for a long-term anticoagulation.

Design
In this prospective, single-centre observational study, 12 PEG-treated patients with indication to anticoagulation will receive edoxaban via PEG and will be followed up to 6 months. Plasma antifactor Xa activity and edoxaban concentrations will be assessed. Thromboembolic (ischaemic stroke, systemic embolism, venous thromboembolism) and bleeding events (Bleeding Academic Research Consortium and Thrombolysis in Myocardial Infarction) will be recorded at 1 and 6 months.

Preliminary results
A retrospective analysis of five atrial fibrillation cases undergoing PEG implantation at our Institution who received edoxaban via PEG showed plasma anti-FXa levels at a steady state of 146 ± 15 ng/ml, without major adverse event at a mean follow-up of 6 months.

Conclusion
ORIGAMI prospectively investigates PEG-administration of edoxaban in PEG-treated patients requiring long-term anticoagulation. Our preliminary retrospective data support this route of DOAC administration.

ClinicalTrials.gov Identifier
NCT04271293
Microstructure and hardness of Pyrowear 53 steel after low-pressure vacuum carburizing at 921°C
Authors: Wojtyczka Artur , Iżowski Bartosz 
Published: November 2020

Abstract
The present paper studies and analyzes the low-pressure vacuum carburizing of Pyrowear 53 steel. The carburizing was performed at 921°C. The results after the completion of the treatment process are presented, i.e. microstructure of the surface layer and hardness. The results confirm that carburizing can be effectively used in hardening of the steel.
Thermal Properties of Plaster Reinforced with Date Palm Fibers
Authors: Rachedi Mokhtar , Kriker Abdelouahed 
Published: November 2020

Abstract
This study aims both to investigate the thermal properties of plaster reinforced with date palm fibers and local natural resources valorization to batter using materials construction. For that, studying the effect of addition date palm fibers on the plaster's thermal properties is a significant point. In this work, we measured effective thermal conductivity, thermal diffusivity, specific heat, and thermal effusivity of date palm fibers reinforced plaster has been studied by CT meter. Samples configurations with four lengths (10 mm - 40 mm) and four-weight ratios (0.5 % - 2 %) of palm fibers in plaster. The results obtained demonstrate that an increase in the fraction of date palm fiber engenders to a significant decrease in the thermal conductivity, thermal diffusivity, and effusivity, even an increase for the specific heat of different types of samples. Finally, this study is a contribution to the valorization of local materials in southern Algeria, and results encourage the use of plaster and date palm fibers in the field of construction and go to eco-friendly buildings.
Impact of Igneous Rock Admixtures on Geotechnical Properties of Lime Stabilized Clay
Authors: Shah Syed Husnain Ali , Arif Muhammad , Sabir Mohammad Amjad , Rehman Qasim ur 
Published: November 2020

Abstract
This paper investigates the probable influence of powder from two igneous rocks, namely granite and rhyolite, on the geotechnical properties of lime stabilized clay soil. A clay soil sample was collected from Jhelum, city of the province Punjab in Pakistan, and its major geotechnical properties including particle size distribution, Atterberg limits, Activity, compaction parameters, California Bearing Ratio (CBR) and unconfined compressive strength (UCS) were determined by using standard ASTM procedures. Owing to the presence of clay minerals, the Jhelum soil is classified as CH soil (Fat clays) following the Unified classification system. Lime was added to the soil in the range of 0 – 12 % and the most influential lime percentage, i.e. the one causing the highest possible positive impact on geotechnical properties, was chosen for further stabilization. Following a gradual increase by 8 %, up to 32 % of granite and rhyolite powders were separately mixed with the soil sample showing maximum stabilization with lime, i.e. the sample containing 6 % lime. Each of the resulting samples was tested for all the parameters mentioned above. The results demonstrate that addition of granite and rhyolite powders produces significant improvement in workability and performance of the clay soil previously stabilized with 6 % lime. The improvement is obvious from reduction in Plasticity index, Activity and optimum moisture content, and rapid increase in UCS, maximum dry density and CBR. The principal reason for the observed positive changes is the presence of abundant non-active and denser minerals in granite and rhyolite powders as compared to lime and clay soil. Furthermore, the positive impact of rhyolite on the geotechnical behaviour of soil is relatively higher than granite obviously because of its better petrographic features, physical properties and strength.
Do foreign-educated nurses displace native-educated nurses?
Authors: Chung Hyeran , Arends-Kuenning Mary 
Published: November 2020

Abstract
We examine whether there is any movement in the employment of native-educated nurses due to the influx of foreign-educated nurses. To avoid conflating the short- and long-term reactions to the entry of newly arrived foreign-educated nurses, we implement a multiple instrumentation procedure. We find that there is no significant effect of foreign-educated nurses on the employment of native nurses in both the short- and the long-runs. Our results suggest that relying on foreign-educated nurses to fill gaps in the US healthcare workforce does not harm the employment of native nurses.
Serum metabolomic analysis of feline mammary carcinomas based on LC-MS and MRM techniques
Authors: Zheng Jia-san , Wei Ren-yue , Wang Zheng , Song Jun , Ge Yan-song , Wu Rui 
Published: November 2020

Abstract

Introduction
To date, there have been no panoramic studies of the serum metabolome in feline mammary carcinoma. As the first such study, metabolomics techniques were used to analyse the serum of cats with these tumours. Three important metabolic pathways of screened differential metabolites closely related to feline mammary carcinomas were analysed to lay a theoretical basis for further study of the pathogenesis of these carcinomas.

Material and Methods
Blood in a 5–8 mL volume was sampled from twelve cats of the same breed and similar age (close to nine years on average). Six were feline mammary carcinoma patients and six were healthy. L glutamate, L alanine, succinate, adenine, hypoxanthine, and inosine were screened as were alanine, aspartate, and glutamate metabolism, the tricarboxylid acid (TCA) cycle, and purine metabolism. Data were acquired with LC-MS non-target metabolomics, multiple reaction monitoring target metabolomics, and multivariate statistical and bioinformatic analysis.

Results
Expression of five of the metabolites was upregulated and only inosine expression was downregulated. Up- and downregulation of metabolites related to glycometabolism, potentiation of the TCA cycle, greater content of lipid mobilisation metabolites, and abnormality of amino acid metabolism were closely related to the occurrence of the carcinomas.

Conclusion
These findings provide a new direction for further study of the mechanisms associated with cat mammary neoplasms.
Occurrence of gastrointestinal parasites in camels in the Tianshan Mountains pastoral area in China
Authors: Guowu Zhang , Kai Zhang , Xifeng Wang , Chunhui Ji , Chengcheng Ning , Yue Zhao , Jun Qiao , Qingling Meng , Xingxing Zhang , Kuojun Cai , Jinsheng Zhang , Zaichao Zhang , Xuepeng Cai 
Published: November 2020

Abstract

Introduction
Gastrointestinal parasites are some of the most common pathogens which are seriously harmful to the camel’s health. The infection status of gastrointestinal parasites in camels (Camelus bactrianus) in the Tianshan Mountains pastoral area in China is still unclear. The aim of this study was to investigate the species and infection intensity of gastrointestinal tract parasites in local camels.

Material and Methods
A total of 362 fresh faecal samples were collected and examined for parasite eggs using the saturated saline floating and natural sedimentation method. The parasite eggs were subjected to morphological and molecular examination and identification, and the infection rate and mean intensity of the parasites were analysed.

Results
A total of 15 gastrointestinal tract parasite species’ eggs were identified, with a detection rate of 100%. Ostertagia spp. (100%) and Trichostrongylus spp. (98.1%) were dominant. Camels were often coinfected by 5–14 species. The average number of eggs per gram of faeces was higher for Ostertagia spp. (298), Haemonchus contortus (176) and Nematodirus spp. (138). The number of species of parasites infecting young camels was significantly lower than that of adult camels, but the infection intensity in young camels was significantly higher.

Conclusion
Gastrointestinal parasites were highly prevalent in camels from the Tianshan Mountains pastoral area in China. This finding provides important epidemiological data for the prevention and control of associated infections in camels.
The ANTI-Vea task: analyzing the executive and arousal vigilance decrements while measuring the three attentional networks
Authors: Luna Fernando G. , Barttfeld Pablo , Martín-Arévalo Elisa , Lupiáñez Juan 
Published: November 2020

Abstract
The vigilance decrement phenomenon has been traditionally studied by simple and monotonous behavioral tasks. Nowadays, however, there is considerable interest in measuring vigilance with more complex tasks, including independent measures of other attentional functions. In the present study, we provide evidence supporting the suitability of the Attentional Networks Test for Interactions and Vigilance – executive and arousal components (ANTI-Vea) as an appropriate method to simultaneously assess multiple attentional and vigilance components. Vigilance was examined as two dissociated components: executive vigilance –as the detection of infrequent signals– and arousal vigilance –as the sustenance of a fast reaction to stimuli without response selection–. Importantly, the executive vigilance decrement was analyzed with a novel methodological approach to particularly determine whether the sensitivity loss effect is influenced by a floor level on the false alarms. As expected, the ANTI-Vea proved to be a task suitable to assess: (a) the main effects and interactions of phasic alertness, orienting, and executive control; (b) the executive vigilance decrement as a progressive change in the response bias; and (c) the arousal vigilance decrement as a progressive slowness and variability in reaction time. We discuss some critical theoretical and empirical implications of measuring vigilance components with the ANTI-Vea task. We expect the present study to provide a suitable method to analyze the vigilance decrement phenomenon when measuring multiple attentional and vigilance functions.
Molecular and cellular mechanisms of glioblastoma resistance to vascular endothelial growth factor inhibitors
Authors: Степанов И.А. , Белобородов В.А. , Шамеева М.А. 
Published: November 2020

Представлен обзор современных источников литературы, посвященных изучению молекулярных и клеточных механизмов резистентности глиобластомы к антиангиогенным лекарственным средствам. Ангиогенез представляет собой важнейший патофизиологический механизм роста и прогрессирования глиобластомы за счет активного развития микрососудистой сети. Ускоренное развитие микрососудистой сети в глиобластоме происходит благодаря синтезу опухолевыми клетками большого количества фактора роста эндотелия сосудов (Vascular Endothelial Growth Factor, VEGF). Среди основных молекулярных и клеточных механизмов лекарственной устойчивости глиобластомы к анти-VEGF агентам принято относить VEGF-независимые пути ангиогенеза, активность клеток костного мозга и перицитов, а также сосудистую кооперацию, периваскулярную инвазию и феномен аутофагии. Изложены современные данные о рациональном и наиболее эффективном использовании анти-VEGF-лекарственных средств у пациентов с глиомами высокой степени злокачественности. Обозначены актуальные, остающиеся нерешенными вопросы, что обусловливает необходимость проведения дальнейших экспериментальных и клинических исследований, посвященных изучению механизмов лекарственной устойчивости глиобластомы к анти-VEGF-препаратам.
This state-of-the-art review focuses on molecular and cellular factors associated with glioblastoma resistance to antiangiogenic drugs. Angiogenesis is an important pathophysiological mechanism for the growth and progression of glioblastoma facilitated by active development of microvasculature. The accelerated development of the microvascular network in glioblastoma occurs due to the synthesis of a large number of vascular endothelial growth factor (VEGF) by tumor cells Among the major molecular and cellular factors, glioblastoma drug resistance to anti-VEGF agents is commonly attributed to VEGF-independent pathways of angiogenesis, bone marrow cell and pericyte activity as well as to vascular co-option, perivascular invasion, and the phenomenon of autophagy. The authors provided current data on the rational and most effective use of anti-VEGF drugs for patients with high-grade gliomas. Relevant unsolved problems associated with drug resistance of glioblastoma to anti-VEGF drugs were highlighted.
Idiopathic normal pressure hydrocephalus. Retrospective review of pathogenesis and modern theories
Authors: Гаврилов Г.В. , Станишевский А.В. , Гайдар Б.В. , Свистов Д.В. 
Published: November 2020

Идиопатическая нормотензивная гидроцефалия - хроническое прогрессирующее дегенеративное заболевание головного мозга, характеризующееся изменением конфигурации боковых желудочков и других ликворсодержащих пространств головного мозга на фоне нормального давления ликвора, проявляющееся клинически триадой симптомов: нарушением походки, развитием деменции и нарушением мочеиспускания. Патофизиология и патоморфогенез этого заболевания до конца не ясны. С появлением термина и описания клинической картины нормотензивной гидроцефалии в 1964 г. S. Hakim выполнено множество экспериментальных, морфологических и клинических исследований, направленных на выяснение ключевых звеньев патогенеза заболевания. В представленной работе приведена ретроспектива взглядов на закономерности патогенеза идиопатической нормотензивной гидроцефалии, анализируются современные исследования, посвящённые данной проблеме, а также обобщены и сформулированы основные теории, касающиеся ключевых звеньев патологического процесса.
Idiopathic normal pressure hydrocephalus is a chronic, progressive degenerative brain disease characterized by ventricular enlargement disproportionate to other cerebrospinal fluid (CSF) spaces with normal CSF pressure. This disease presents with gait disturbance, cognitive impairment, and incontinence. The pathophysiology and morphogenesis of this condition are not well studied. Since the first description by S. Hakim in 1964, a number of experimental and morphological studies have focused on investigation of the disease mechanisms. This review retrospectively analyzed and summarized principal ideas about the pathogenesis of idiopathic normal pressure hydrocephalus.
The Comparison of FLACC and OPS Scales in Differentiating Pain and Emergence Delirium in the Postoperative Period in Pediatric Patients
Authors: PEKER Kevser , PEKER Seydi Ali 
Published: November 2020

Objective: Postoperative pain and pediatric emergence delirium (ED) are early-postoperative negative behaviours. However it is very difficult to diferentiate each other. The aim of the present study is to compare the utility of “Face, legs, Activity, Cry, Consolability” (FLACC) and Objective Pain Scale (OPS) in differentiating the pain and ED in the early postoperative period. Materials and Methods: This prospective study was conducted at a university hospital. Sixty one (61) children were included in this study. General anesthesia was provided for all children. The incidence of ED was evaluated with PAED scale, the incidence of pain was evaluated with both FLACC and OPS scales in the early postoperative period. Results: Only the number of children with delirium were 29 (47.5%), with pain were 10 (16.4%) and with both delirium and pain were 25 (40.9%). For FLACC, the area under the curve (AUC = 0.914, p = 0.02) at the 5th minute and the area under the curve value (AUC = 0.865, p &lt; 0.001) at the 15th minute was high. Conclusions: The utility of FLACC is better than OPS in differentiating pain and emergence delirium in the postoperative period in pediatric patients.
Indeks Kedalaman dan Keparahan Kemiskinan di Provinsi Nusa Tenggara Barat dan Penanganannya Dalam Ekonomi Islam
Authors: M. Irwan  
Published: November 2020

Penelitian ini bertujuan untuk mengetahui : Jumlah Penduduk yang tergolong miskin, Indeks Kedalaman dan Keparahan Kemiskinan di Provinsi Nusa Tenggara Barat dan Penanganannya Dalam Ekonomi Islam. Metode Penelitian yang dipergunakan adalah metode deskriptif, data yang dipergunakan data sekunder dan alat analisis yang dipergunakan adalah teknik analisis pertumbuhan. Hasil penelitian menunjukkan bahwa Kondisi kemiskinan di Nusa Tenggara Barat dilihat dari jumlah penduduk mengalami penurunan dengan rata-rata pertumbuhan negatif 3,19 persen. Persentase penduduk pada tahun 2016 sebesar 16,02 persen. Penduduk miskin di daerah pedesaan sebesar 14,82 persen dan 17,55 persen untuk daerah perkotaan pada tahun 2016. Garis kemiskinan untuk penduduk miskin di daerah perkotaan Rp 346.581sedangkan untuk di daerah pedesaan Rp 328.775,- pada tahun 2016. Indeks Kedalaman (P1) kemiskinan di NTB pada tahun 2016 sebesar 2,626 yang menunjukkan bahwa kondisi perekonomian penduduk miskin berada dalam kondisi yang membaik. Indeks Keparahan Kemiskinan (P2) di NTB pada tahun 2016 sebesar 0,653 pada tahun 2016 yang menunjukkan ketimpangan pengeluaran penduduk miskin semakin menyempit. Pengentasan kemiskinan dalam Islam dapat dilakukan salah satunya melalui perintah zakat. Baznas Provinsi Nusa Tenggara Barat telah mampu menghimpun dana Zakat, Infaq dan Shadaqah (ZIS) dan berkontribusi dalam pengentasan kemiskinan di Nusa Tenggara Barat. Jumlah dana ZIS yang berhasil dihimpun pada tahun 2016 mencapai Rp 8.288.499.700,- dari target sebesar Rp 7.500.000.000,-
Marketing Strategy Pariwisata Melalui Marketing Mix Strategy Dan Pengembangan Pariwisata di Kabupaten Lombok Utara (KLU)
Authors: Irwan Suriadi  , Didy Ika Supryadi  
Published: November 2020

Penelitian ini berjudul “Marketing Strategy Pariwisata Melalui Marketing Mix Strategy dan pengembangan Pariwisata di Kabupaten Lombok Utara (KLU)”. Rumusan masalah dalam penelitian ini adalah (a) Bagaimana strategi bauran pemasaran pariwisata di Kabupaten Lombok Utara (KLU) (b) Faktor-faktor apa saja yang menjadi kekuatan,kelemahan,ancaman dan peluang pengembangan pariwisata di Kabupaten Lombok Utara (KLU), (c)Bagaimana pengembangan pariwisata di Kabupaten Lombok Utara (KLU),Tujuan penelitian ini adalah (a) Untuk Menganalisis bagaimana strategi bauran pemasaran pariwisata di kabupaten Lombok utara.(b)Faktor-faktor apa saja yang menjadi kekuatan,kelemahan,ancaman dan peluang pengembangan pariwisata di kabupaten Lombok Utara (c) Untuk merumuskan strategi pengembangan pariwisata di Kabupaten Lombok Utara. Jenis penelitian ini adalah penelitian kualitatif yang mencoba mencari gambaran dan strategi pemasarn pariwisata yang sesuai di kabupaten Lombok utara (KLU). Metode Analisis yang digunakan dalam penelitian ini adalah Analisis Deskriptif dan SWOT Analisys. Hasil penelitian menunjukkan bahwa Faktor strategi internal (kekuatan) yang memiliki kekuatan utama adalah Keunikan di tempat wisata, Faktor strategi internal (Kelemahan) yang memiliki kelemahan yang utama adalah Faktor Palayanan kepada wisatawan di kawasan wisata, Peluang utama pariwisata KLU adalah Letak daerah wisata yang strategis, Faktor strategi Eksternal (Ancaman) yang memiliki ancaman utama adalah Persaingan pariwisata yang semakin ketat, Strategi pengembangan pariwisata di KLU adalah Dinas pariwisata kabupaten Lombok utara (KLU) harus sering mengadakan iven-iven pariwisata di kabupaten Lombok utara (KLU) dan mengikuti ivent promosi di dalam dan diluar negeri.
Analisis VAR (Vector Autograsive) Permintaan Dan Penawaran Kunjungan Wisatawan Domestik Di Kabupaten Lombok Utara (KLU)
Authors: Himawan Sutanto  
Published: November 2020

Penelitian ini berjudul “Analisis VAR (Vector Autograsive) Permintaan dan Penawaran Kunjungan Wisatawan Di Kabupaten Lombok Utara (KLU)”. Rumusan masalah dalam penelitian ini adalah (a) apakah variable-variabel yang menentukan permintaan dan penawaran wisatawan di Kabupaten Lombok Utara (KLU), (b) apakah variabel yang paling menentukan permintaan dan penawaran wisatawan di Kabupaten Lombok Utara (KLU) Tujuan penelitian ini adalah (a) untuk mengetahui variable-variabel yang menentukan permintaan dan penawaran kunjungan wisatawan di Kabupaten Lombok Utara (KLU), (b) untuk mengetahui variabel yang paling menentukan permintaan dan penawaran kunjungan wisatawan di Kabupaten Lombok Utara (KLU. Data yang digunakan dalam penelitian ini adalah data sekunder yang berasal dari Dinas Pariwisata KLU, Badan Pusat Statistik (BPS) NTB, Bank Indonesia. Variabel Penelitian yang digunakan adalah permintaan dan penawaran kunjungan wisatawan di Kabupaten Lombok Utara (KLU) seperti Tingkat Inflasi NTB, PDRB NTB,Inflasi KLU, PDRB KLU. Teknik analisis data yang digunakan dalam penelitian ini adalah Analisis VAR (Vector Autograsive) dengan bantuan software Eviews. Hasil Penelitian menunjukkan bahwa Variabel Inflasi Provinsi, PDRB Provinsi memiliki pengaruh yang signifikan terhadap Permintaan kunjungan wisatawan Domestik di Kabupaten Lombok Utara (KLU).
Analisis Penentuan Desa Pusat Pertumbuhan Di Kecamatan Lembar Kabupaten Lombok Barat
Authors: Emi Salmah  , Sahri  , Endang Astuti  
Published: November 2020

Penelitian ini bertujuan untuk: a). Mengidentifikasi ketersediaan sarana dan prasarana masing - masing desa di Kecamatan Lembar, b). Menentukan desa yang sesuai untuk dikembangkan sebagai Desa Pusat Pertumbuhan di Kecamatan Lembar. Jenis penelitian yang digunakan adalah penelitian diskriptif. Hasil penelitian menunjukkan bahwa, sarana dan prasarana yang ada di Kecamatan Lembar secara umum sudah cukup tersedia dan sudah mendukung dalam pembentukan Desa Pusat Pertumbuhan. Desa yang sesuai untuk dikembangkan sebagai Desa Pusat Pertumbuhan adalah Desa Jembatan Kembar karena bobot yang diperoleh dari 7 ( tujuh ) variabel penentu DPP sebesar 73, yang artinya Desa Jembatan Kembar. memiliki sarana dan prasarana serta memiliki potensi yang mendukung terbentuknya Desa Pusat Pertumbuhan di Kecamatan Lembar Kabupaten Lombok Barat. Mengacu pada hasil analisis dan pembahasan pada bab sebelumnya serta mengacu pada hasil penelitian di atas, maka dapat diajukan saran - saran yaitu perlu diadakan pembangunan beberapa sarana dan prasarana untuk lebih meningkatkan fungsi Desa Jembatan Kembar sebagai pusat pertumbuhan bagi daerah – daerah hinterlandnya seperti sarana komunikasi, pendidikan, serta pengadaan badan usaha atau perusahaan.