bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of the industry format on sustainability-oriented service innovation, relationship value, and firm performance
Authors: Marín-García Antonio , Gil-Saura Irene , Ruiz-Molina María Eugenia , Moise Mihaela Simona 
Published: February 2025

Abstract
This paper explores the impact of the sustainability-oriented service innovation (SOSI) construct on relationship value and organizational performance in the service sectors from the business’ perspective. In order to achieve this goal, a theoretical model based on the literature is proposed through an empirical study carried out on a sample of 450 managers and supervisors of retail establishments and hotels. Findings support the critical role of SOSI in enhancing relationship value and driving economic and non-economic benefits. Significant industry-specific differences are revealed, offering valuable insights for managers to design effective, sustainability-aligned customer communication and value creation strategies.
A surrogate FRAX model for Mongolia
Authors: Jaalkhorol M. , Johansson H. , Avirmed S. , Dashtseren A. , Bruyère O. , Lorentzon M. , Harvey N. C. , McCloskey E. V. , Kanis J. A. 
Published: February 2025

Abstract

Summary
A surrogate FRAX® model for Mongolia has been constructed using age- and sex-specific hip fracture rates for mainland China and age- and sex-specific mortality rates from Mongolia.

Introduction
FRAX models are frequently requested for countries with little or no data on the incidence of hip fracture. In such circumstances, the development of a surrogate FRAX model is recommended based on country-specific mortality data but using fracture data from a country, usually within the region, where fracture rates are considered to be representative of the index country.

Objective
This report describes the development and characteristics of a surrogate FRAX model for Mongolia.

Methods
The FRAX model used the ethnic-specific incidence of hip fracture in mainland China, combined with the death risk for Mongolia in 2015–2019. Intervention thresholds were developed based on fracture probabilities equivalent to women with a prior fragility fracture, and their impact was assessed in a referral cohort comprising men at age 50 and above and postmenopausal women. The number of hip fractures in 2015 and 2050 was estimated based on United Nations’ predicted changes in population demography.

Results
The surrogate model gave similar hip fracture probabilities to estimates from China. Age-dependent intervention thresholds for a major osteoporotic fracture ranged from a 10-year probability of 2.4% at the age of 40 years to 13.7% at the age of 90 years. In the cohort of those eligible for assessment, 46% of men and 36% of women were eligible for treatment because of a prior fracture. Based on intervention thresholds, a further 0.5% of men and 7.0% of women would be eligible for treatment. It was estimated that 440 hip fractures arose in 2015 in individuals aged 50 years and older in Mongolia, with a predicted 4.3-fold increase expected by 2050, when 1896 hip fractures are expected nationally.

Conclusion
The surrogate FRAX model for Mongolia provides an opportunity to determine fracture probability within the Mongolian population and help guide decisions about treatment.
Modeling of the Stress Path-Dependent Strain Ratcheting Behaviour of 304L Stainless Steel Through Crystal Plasticity Frameworks
Authors: Acar Sadik Sefa , Yalçinkaya Tuncay 
Published: February 2025

Abstract
This study investigates the strain ratcheting behavior of 304L stainless steel under complex stress-controlled cyclic loading conditions employing crystal plasticity models in the DAMASK framework. Strain ratcheting, a phenomenon characterized by the accumulation of plastic strain during cyclic loading, is particularly important in industries such as aerospace and nuclear energy, where components are subjected to non-proportional multiaxial loading. A polycrystalline representative volume element with 200 randomly oriented grains was generated to predict the material response under various stress paths, including Uniaxial, Shear, Cross, Square, and Circle loading conditions. Two crystal plasticity models were used: a phenomenological power-law (PP) model and a combined isotropic-kinematic hardening (IK) model. Simulations were conducted to identify parameters under monotonic and cyclic strain-controlled loading conditions. Model parameters are identified by using experimental results from literature and conducting strain-controlled uniaxial monotonic and cyclic loading simulations for PP and IK models, respectively. In addition, FEM and spectral solvers are compared for monotonic and cyclic loading conditions, and very similar macroscopic responses are obtained. The uniaxial strain ratcheting simulations under stress-controlled cyclic loading were compared against experimental data, with the IK model producing closer results due to its back-stress and memory terms. The analysis also revealed that the mechanical response, both at the macroscopic and local levels, is highly sensitive to the applied stress path, with significant differences in strain accumulation observed across different loading conditions. Torsional and axial strain evolutions were analyzed in detail, showing that the PP and IK models each performed better under certain stress paths. This study emphasizes the critical role of stress path effects in strain ratcheting and the variation in torsional and axial ratcheting predictions of two models for different stress paths.

Graphic Abstract
Bioinspired Trailing Edge Serrations for Vertical Axis Wind Turbine Blades in Urban Environments: Performance Effects
Authors: Santamaría Luis , Suarez Fernandez Laura , Garcia-Diaz Manuel , González Pérez José , Galdo Mónica 
Published: February 2025

Abstract
Biomimetics has recently emerged as an interesting approach to enhance renewable energy technologies. In this work, bioinspired Trailing Edge Serrations (TES) were evaluated on a typical Vertical Axis Wind Turbine (VAWT) airfoil, the DU06-W200. As noise reduction benefits of these mechanisms are already well-established, this study focuses on their impact on airfoil and VAWT performance. A saw-tooth geometry was chosen based on VAWT specifications and existing research, followed by a detailed assessment through wind tunnel tests using a newly developed aerodynamic balance. For a broad spectrum of attack angles and Reynolds numbers, lift, drag, and pitching moments were carefully measured. The results show that TES enhance the lift-to-drag ratio, especially in stalled conditions, and postpone stall at negative angles, expanding the effective performance range. A notable increase in pitching moment also is also observed, relevant for blade-strut joint design. Additionally, the impact on turbine performance was estimated using an analytical model, demonstrating excellent accuracy when compared against previous experimental results. TES offer a modest 2% improvement in peak performance, though they slightly narrow the optimal tip-speed ratio zone. Despite this, the potential noise reduction and performance gains make TES a valuable addition to VAWT designs, especially in urban settings.
Influence of microwave treatment conditions and acid concentration on pyrodextrinization of sweet potato (Ipomoea batatas Lam.) starch using response surface methodology
Authors: Tsatsop Roli Karole Tsague , Kom Raissa Regonne , Djiobie Gertrude Eleonore Tchienou , Chendjou Stive Martial Sikandi , Nkenmogne Sidonie Beatrice , Nguimbou Richard Marcel , Ngassoum Martin Benoit 
Published: February 2025

Abstract
Microwave irradiation provides advantages including homogeneous and rapid heating, significant reaction acceleration due to heating rate and selective heating. This study aims to optimize the microwave assisted pyrodextrinization of sweet potato (I. batatas Lam.) starch isolated from tubers grown in Central Africa to produce a yellow pyrodextrin with improved structural and functional properties. The effects irradiation of power (80—100 W), Acid to starch ratio (1.5—3.0 g HCl/kg of starch) and number of cycle/time unit (4—6 cycles with 20 s/cycle) on the response variables were investigated using Response Surface Methodology (RSM). The physicochemical characteristics were also determined on pyrodextrins obtained in optimal conditions by microwave pyroconversion process. The positive interactions were observed between Irradiation power (X1) and Acid to starch ratio (X2) and between Acid to starch ratio (X2) and number of cycle/time unit (X3) for Color index response (P < 0.05). The Acid to starch ratio and its quadratic effect had significant (P < 0.05) influence on saccharification percentage. Th optimal condition for the domain of study were: irradiation power 84 W; Acid to starch ratio of 3.14 g HCl/Kg of starch and number of cycle/time unit of 4.6 for 20 s per cycle. The characteristic of microwave assisted pyrodextrin were: saccharification percentage 92.5%, solubility 98.20%. Its relative crystallinity of 20.97% compared to 26.32% of native starch from XRD and glass transition temperature Tg 144 °C from DSC. The FTIR analysis suggested that of native starch native starch had more short-range order than pyrodextrin. Yellow pyrodextrin with high solubility might be produced in a comparatively short amount of time using microwave assisted treatment.
Depth Dependence of Coseismic Off‐Fault Damage and Its Effects on Rupture Dynamics
Authors: Ferry Roxane , Thomas Marion Y. , Bhat Harsha S. , Dubernet Pierpaolo 
Published: February 2025

AbstractFaults are complex systems embedded in an evolving medium fractured by seismic ruptures. This off‐fault damage zone is shown to be thermo‐hydro‐mechano‐chemically coupled to the main fault plane by a growing number of studies. Yet, off‐fault medium is still, for the most part, modeled as a purely elastic—hence passive—medium. Using a micromechanical model that accounts for dynamic changes of elastic moduli and inelastic strains related to crack growth, we investigate the depth variation of dynamically triggered off‐fault damage and its counter‐impact on earthquake slip dynamics. We show that the damage zone, while narrowing with depth, also becomes denser and contrary to prevailing assumptions continues to act as an energy sink, significantly influencing rupture dynamics by stabilizing slip rates. Furthermore, we observe that damage formation markedly reduces rupture velocity and delays, or even prevents, the transition to supershear speeds even for a narrow damage zone. This underscores the critical need to incorporate the complex interplay between the main fault plane and its surrounding medium across the entire seismogenic zone. As a proof of concept, we introduce a 1D spring‐slider model that captures bulk elastic variations, by modulating spring stiffness, and normal stress variations that emulate changes in bulk load. This simple model demonstrates the occurrence of slow slip events alongside conventional earthquakes, driven by the dynamic interaction between bulk temporal evolution and fault slip dynamics, without necessitating any changes to frictional properties.
Molecular principles underlying aggressive cancers
Authors: Nussinov Ruth , Yavuz Bengi Ruken , Jang Hyunbum 
Published: February 2025

Abstract
Aggressive tumors pose ultra-challenges to drug resistance. Anti-cancer treatments are often unsuccessful, and single-cell technologies to rein drug resistance mechanisms are still fruitless. The National Cancer Institute defines aggressive cancers at the tissue level, describing them as those that spread rapidly, despite severe treatment. At the molecular, foundational level, the quantitative biophysics discipline defines aggressive cancers as harboring a large number of (overexpressed, or mutated) crucial signaling proteins in major proliferation pathways populating their active conformations, primed for their signal transduction roles. This comprehensive review explores highly aggressive cancers on the foundational and cell signaling levels, focusing on the differences between highly aggressive cancers and the more treatable ones. It showcases aggressive tumors as harboring massive, cancer-promoting, catalysis-primed oncogenic proteins, especially through certain overexpression scenarios, as predisposed aggressive tumor candidates. Our examples narrate strong activation of ERK1/2, and other oncogenic proteins, through malfunctioning chromatin and crosslinked signaling, and how they activate multiple proliferation pathways. They show the increased cancer heterogeneity, plasticity, and drug resistance. Our review formulates the principles underlying cancer aggressiveness on the molecular level, discusses scenarios, and describes drug regimen (single drugs and drug combinations) for PDAC, NSCLC, CRC, HCC, breast and prostate cancers, glioblastoma, neuroblastoma, and leukemia as examples. All show overexpression scenarios of master transcription factors, transcription factors with gene fusions, copy number alterations, dysregulation of the epigenetic codes and epithelial-to-mesenchymal transitions in aggressive tumors, as well as high mutation loads of vital upstream signaling regulators, such as EGFR, c-MET, and K-Ras, befitting these principles.
A multiparametric anti-aging CRISPR screen uncovers a role for BAF in protein synthesis regulation
Authors: Breusegem Sophia Y. , Houghton Jack , Romero-Bueno Raquel , Fragoso-Luna Adrián , Kentistou Katherine A. , Ong Ken K. , Janssen Anne F. J. , Bright Nicholas A. , Riedel Christian G. , Perry John R. B. , Askjaer Peter , Larrieu Delphine 
Published: February 2025

Abstract
Progeria syndromes are very rare, incurable premature aging conditions recapitulating most aging features. Here, we report a whole genome, multiparametric CRISPR screen, identifying 43 genes that can rescue multiple cellular phenotypes associated with progeria. We implement the screen in fibroblasts from Néstor-Guillermo Progeria Syndrome male patients, carrying a homozygous A12T mutation in BAF. The hits are enriched for genes involved in protein synthesis, protein and RNA transport and osteoclast formation and are validated in a whole-organism Caenorhabditis elegans model. We further confirm that BAF A12T can disrupt protein synthesis rate and fidelity, which could contribute to premature aging in patients. This work highlights the power of multiparametric genome-wide suppressor screens to identify genes enhancing cellular resilience in premature aging and provide insights into the biology underlying progeria-associated cellular dysfunction.
Genetic regulation of TERT splicing affects cancer risk by altering cellular longevity and replicative potential
Authors: Florez-Vargas Oscar , Ho Michelle , Hogshead Maxwell H. , Papenberg Brenen W. , Lee Chia-Han , Forsythe Kaitlin , Jones Kristine , Luo Wen , Teshome Kedest , Blauwendraat Cornelis , Billingsley Kimberly J. , Kolmogorov Mikhail , Meredith Melissa , Paten Benedict , Chari Raj , Zhang Chi , Schneekloth John S. , Machiela Mitchell J. , Chanock Stephen J. , Gadalla Shahinaz M. , Savage Sharon A. , Mbulaiteye Sam M. , Prokunina-Olsson Ludmila 
Published: February 2025

Abstract
The chromosome 5p15.33 region, which encodes telomerase reverse transcriptase (TERT), harbors multiple germline variants identified by genome-wide association studies (GWAS) as risk for some cancers but protective for others. Here, we characterize a variable number tandem repeat within TERT intron 6, VNTR6-1 (38-bp repeat unit), and detect a strong link between VNTR6-1 alleles (Short: 24-27 repeats, Long: 40.5-66.5 repeats) and GWAS signals rs2242652 and rs10069690 within TERT intron 4. Bioinformatics analyses reveal that rs10069690-T allele increases intron 4 retention while VNTR6-1-Long allele expands a polymorphic G-quadruplex (G4, 35-113 copies) within intron 6, with both variants contributing to variable TERT expression through alternative splicing and nonsense-mediated decay. In two cell lines, CRISPR/Cas9 deletion of VNTR6-1 increases the ratio of TERT-full-length (FL) to the alternative TERT-β isoform, promoting apoptosis and reducing cell proliferation. In contrast, treatment with G4-stabilizing ligands shifts splicing from TERT-FL to TERT-β isoform, implicating VNTR6-1 as a splicing switch. We associate the functional variants VNTR6-1, rs10069690, and their haplotypes with multi-cancer risk and age-related telomere shortening. By regulating TERT splicing, these variants may contribute to fine-tuning cellular longevity and replicative potential in the context of stress due to tissue-specific endogenous and exogenous exposures, thereby influencing the cancer risk conferred by this locus.
Modelling the high-voltage grid using open data for Europe and beyond
Authors: Xiong Bobby , Fioriti Davide , Neumann Fabian , Riepin Iegor , Brown Tom 
Published: February 2025

Abstract
This paper provides the background, methodology and validation for constructing a representation of the European high-voltage grid (AC lines from 220 to 750 kV and all DC lines) based on OpenStreetMap data. Grid components include commissioned substations, transmission lines and cables, transformers, and converters as well as technical parameters based on standard types. The data is provided as easy-to-access comma-separated values files which makes it suitable for model-independent, large-scale electricity and energy system modelling. For further ease-of-use, an interactive map is included to enable visual inspection. To assess the data quality, this paper compares the dataset with official statistics and representative model runs using PyPSA-Eur based on different electricity grid representations. The dataset and workflow are provided as part of PyPSA-Eur, an open-source, sector-coupled optimisation model of the European energy system. By integrating with the codebase for initiatives such as PyPSA-Earth, the benefits of this work of this work extend to the global context. The dataset is published under the Open Data Commons Open Database (ODbL 1.0) licence.
High-quality genome assembly of a cosmopolitan insect predator, Chrysoperla zastrowi sillemi (Esben-Petersen)
Authors: Mohan Muthugounder , Venkatesan Thiruvengadam , Upasna Selvapandian , Selva Babu Selvamani , Aneesha P J , Ashok Karuppannasamy , Roli Budhwar , Gracy Gandhi R , Sushil Satya N 
Published: February 2025

Abstract

Chrysoperla zastrowi sillemi is an extensively employed bio-control agent against crop pests. However, the genomic information on adaptive evolution and predator-prey interaction was lacking to enhance its predatory potential. Here, we presented a high contiguity, chromosomal-level genome assembly of C. zastrowi sillemi using short and long-read sequencing (Illumina and PacBio) coupled with Hi-C. The highly homozygous genome assembly has 597 Mb in span. The assembly contains six chromosomal pseudomolecules, occupying 84% of genome, which range from 29.36 to 170.05 Mb. Genome annotation using Refseq, EggNOG, SwissProt and Eukaryotic Orthologous Groups database has identified 14,495 protein coding genes. The mitochondrial genome is 16 Kb in length with 13 protein-coding genes, 22 tRNAs and three rRNA genes without any gene rearrangements. The genomic information furnished herein could be useful in choosing heritable traits for selective breeding to improve its bio-control potential.
Ecological change and conflict reduction led to a social circulatory system in ants
Authors: Meurville Marie-Pierre , Silvestro Daniele , LeBoeuf Adria C. 
Published: February 2025

Abstract
Behavioral innovations can be ecologically transformative for lineages that perform them and for their associated communities. Many ecologically dominant, superorganismal, and speciose ant lineages use mouth-to-mouth social regurgitation behavior – stomodeal trophallaxis – to share exogenous and endogenous materials within colonies. This behavior is less common in other species-poor, less cooperative ant lineages. How and why trophallaxis evolved and fixed in only some ant clades remains unclear, and whether this trait could be indicative of superorganismality has yet to be established. Here we show that trophallaxis evolved in two main events, in non-doryline formicoids around 130 Ma and in some ponerines around 90 Ma, lineages that today encompass 86% of all ant species. We found that trophallaxis evolved in lineages that began drinking sugary liquids and that had reduced intra-colonial conflict by constraining worker reproductive potential. Evolution of trophallaxis increased net diversification. Causal models indicate that trophallaxis required low reproductive conflict and contributed to the large colony sizes of the ants that use it. This suggests that the evolution of social regurgitation was enabled by both social conflict reduction and opportunistic inclusion of nectar and honeydew in the ant diet during the shifts in terrestrial ecosystems toward flowering plants.
Long-lasting intense cut-off lows to become more frequent in the Northern Hemisphere
Authors: Mishra Aditya N. , Maraun Douglas , Schiemann Reinhard , Hodges Kevin , Zappa Giuseppe , Ossó Albert 
Published: February 2025

Abstract
Cut-off Lows are slow-moving mid-latitude storms that are detached from the main westerly flow and are often harbingers of heavy and persistent rainfall. The assessment of Cut-off Lows in climate models is relatively limited, in fact, there are no studies conducted on the future changes of Cut-off Lows within climate models. Given the importance of Cut-off Lows in leading to severe hazards, here we study them in Coupled Model Intercomparison Project Phase 6’s worst-case future simulations (SSP5-8.5). Most (80%) of the models show that Cut-off Lows with high intensity and longer lifetimes are projected to become more frequent in spring over the land regions of the Northern Hemisphere. Such an increase in Cut-off Low frequency could substantially increase related potential hazards. An increase in Cut-off Low propagation velocity, however, may partly offset this increase in hazard. Lastly, projected changes in the jet stream with possible dynamical linkages to Cut-off Lows corroborate the findings of this study.
Neural codes track prior events in a narrative and predict subsequent memory for details
Authors: Collin Silvy H. P. , Kempner Ross P. , Srivatsan Sunita , Norman Kenneth A. 
Published: February 2025

Abstract
Throughout our lives, we learn schemas that specify what types of events to expect in particular contexts and the temporal order in which these events usually occur. Here, our first goal was to investigate how such context-dependent temporal structures are represented in the brain during processing of temporally extended events. To accomplish this, we ran a 2-day fMRI study (N = 40) in which we exposed participants to many unique animated videos of weddings composed of sequences of rituals; each sequence originated from one of two fictional cultures (North and South), where rituals were shared across cultures, but the transition structure between these rituals differed across cultures. The results, obtained using representational similarity analysis, revealed that context-dependent temporal structure is represented in multiple ways in parallel, including distinct neural representations for the culture, for particular sequences, and for past and current events within the sequence. Our second goal was to test the hypothesis that neural schema representations scaffold memory for specific details. In keeping with this hypothesis, we found that the strength of the neural representation of the North/South schema for a particular wedding predicted subsequent episodic memory for the details of that wedding.