bluuebunny/crossref_metadata_2025_split huggingface dataset:
Upamiętnienia Łodzi żydowskiej – w jaki sposób przeszłość uobecnia się w teraźniejszości
Authors: Gubała-Czyżewska Joanna 
Published: November 2020

Przyglądając się przeszłości każdego miasta, możemy zidentyfikować rozmaite wydarzenia, które pozostają w pamięci jego mieszkańców, obrazach przekazywanych z pokolenia na pokolenie – w przypadku Łodzi jest to niewątpliwie funkcjonowanie w mieście getta żydowskiego. Nie zawsze tak jednak było – pamięć o historii społeczności żydowskiej przekształcała się poprzez długie dekady XX stulecia, by dopiero na początku XXI w. zagościć na dłużej w kanonie ważnych dla tego miasta wydarzeń. Jeszcze 15–20 lat temu w Łodzi obrazy przeszłości skoncentrowane na wielokulturowej historii miasta nie były tak powszechne, plasowały się raczej w obszarze zbiorowego zapomnienia. Od tego czasu jednak – co można wyczytać m.in. z treści obecnych w prasie codziennej, kalendarzu uroczystości rocznicowych czy topograficznej tkance upamiętnień – pamięć o sąsiadach innych narodowości powraca.
W ramach projektu badawczego będącego punktem wyjścia tego artykułu przeprowadzono badania pamięci zbiorowej łodzian, koncentrujące się właśnie na owych nośnikach. Wychodząc od refleksji związanej z kanonem pamięci i roli obrazów pamięci o Łodzi wielokulturowej w kontekście innych wątków pamięci zbiorowej (zdiagnozowanych za pomocą wywiadów kwestionariuszowych), rozważania na temat Łodzi żydowskiej zostały pogłębione także przez obserwację konkretnych działań upamiętniających oraz materialnych przejawów tej pamięci – pomników i tablic upamiętniających stopniowo pojawiających się w mieście w pierwszych dekadach XXI w.
I choć wyniki badań wskazują, iż białe plamy zostały wstępnie zapełnione przez liczne nawiązania w kulturze, turystyce, polityce czy sztuce, warto zadać sobie także pytanie, jak bardzo ta pamięć jest zakorzeniona w działaniach i emocjach współczesnych łodzian.
Prezentowany artykuł stanowi rekapitulację ustaleń poczynionych w ramach rozprawy doktorskiej autorki – jest to jedynie wycinek projektu badawczego, który miał na celu pokazanie specyfiki łódzkiej pamięci o społeczności żydowskiej z wykorzystaniem różnorodnych metod badawczych. Zob. Joanna Gubała-Czyżewska, „Pamięć łodzian o społeczności żydowskiej w kontekście metodologicznych aspektów badań pamięci zbiorowej”, praca doktorska, Uniwersytet Łódzki, Łódź 2018.
Father Stanisław Musiał's Struggle with Memory
Authors: Weksler-Waszkinel Romuald Jakub 
Published: November 2020

I met this priest only twice. On the second occasion, we had a longer conversation: for over an hour we strolled round the gardens of the Jesuits in Cracow, in Kopernika St., where Father Stanisław lived. It was July 2003. That conversation was very important for me; we were supposed to return to it. Unfortunately, we did not. On 15 March 2004 I attended his funeral. The mass, in a full basilica of the Heart of Jesus, was concelebrated by 87 priests led by Cardinal Franciszek Macharski, the then archbishop-metropolitan of Cracow; in attendance were also the bishop of the Evangelical Reformed Church and a Lutheran minister. The main celebrant also led the funeral ceremony at the cemetery, where Father Musiał drew even bigger crowds. The presence of a sizeable group of Jews was something extraordinary, and they had come not only from Poland but also from Israel. Among the Jewish celebrities were three rabbis: the chief rabbi of Poland, the rabbi of Cracow and the Hasidic rabbi of Jerusalem; the latter sang kaddish over the Father's grave. The Jews of Cracow were represented by the chairman of the local community. Israeli ambassador in Poland David Peleg was also present.
Educação à Distância, ensino remoto e as novas tecnologias de informação e comunicação educacionais em um cenário de pré e pós pandemia
Authors: Rodrigues Leôncio Gonçalves , Leandro Cícero dos Santos , Barros Francisco Bernardo de , Braga Ian Henrique Teles , Figuerêdo José Evandro da Silva , Pinheiro Adriana de Alencar Gomes 
Published: November 2020

Uma das primeiras medidas em meados de 2020, foi a suspensão imediata das atividades presenciais em instituições de ensino espalhadas em várias partes do mundo como forma de manter o distanciamento social e evitar a propagação do vírus, tão logo foi deflagrada a emergência de saúde pública em função da disseminação do novo coronavírus (COVID-19). Em face da decretação das novas portarias do Ministério da Educação e Saúde, houve uma orientação e ao mesmo tempo permissão, no sentido de que as instituições de ensino em todo o país, utilizassem de metodologias remotas para continuidade do ano letivo. Dentre os segmentos de transformação, a educação precisou se adequar de modo radical a esses recursos. Essa realidade exigiu dos profissionais da educação habilidades até então não obrigatórias, pois mesmo quem não trabalhava com as Tecnologias Digitais de Informação e Comunicação (TDIC) passou a fazer uso delas. Nesse cenário, o objetivo do presente estudo é analisar as implicações dessas medidas no que se refere a adoção em larga escala do “ensino remoto” como substituição às atividades presenciais e do emprego das novas tecnologias de informação e comunicação nesse processo, inclusive no pós-pandemia. Para tanto, o método utilizado foi de natureza qualitativa do tipo bibliográfico com revisão de literatura em materiais já publicados modo online. O presente estudo sugere que as novas tecnologias, mesmo sendo essenciais para o novo panorama mundial, necessitam, acima de tudo de mais adaptação tanto dos alunos quanto dos professores para se tornarem tecnologias unanimemente eficientes no quesito ensino-aprendizagem.
ROS1 Fusion Mediates Immunogenicity by Upregulation of PD-L1 After the Activation of ROS1–SHP2 Signaling Pathway in Non-Small Cell Lung Cancer
Authors: Cai Liangliang , Duan Jianchun , Qian Li , Wang Zhijie , Wang Shuhang , Li Sini , Wang Chao , Zhao Jie , Zhang Xue , Bai Hua , Wang Jie 
Published: November 2020

The drug resistance of first-line crizotinib therapy for ROS proto-oncogene 1, receptor tyrosine kinase (ROS1) fusion non-small cell lung cancer (NSCLC) is inevitable. Whether the administration of immune checkpoint inhibitor (ICI) therapy is suitable for ROS 1 fusion NSCLCs or after the development of crizotinib resistance is still unknown. In this study, five different crizotinib resistant concentration cell lines (HCC78CR1-5) from primary sensitive HCC78 cells were cultured. Ba/F3 cells expressing crizotinib sensitive ROS1 fusion and crizotinib resistant ROS1-G2032R mutation were used to explore the relationship between ROS1 fusion, ROS1-G2032R mutation and programmed death-ligand 1 (PD-L1) expression and the clinical potential of anti-PD-L1 ICI therapy. The signaling pathway net was compared between HCC78 and HCC78CR1-5 cells using RNA sequencing. Anti- PD-L1 ICI therapy was performed on mouse xenograft models with Ba/F3 ROS1 fusion or ROS1-G2032R mutation. HCC78CR1-5 showed more immunogenicity than HCC78 in immune-related pathways. The PD-L1 expression level was remarkably higher in HCC78CR1-5 with ROS1 fusion upregulation than HCC78 primary cell. Furthermore, the expression of PD-L1 was down-regulated by RNA interference with ROS1 siRNAs and up-regulated lower in Ba/F3 ROS1-G2032R resistant mutation than ROS1 fusion. Western blotting analysis showed the ROS1–SHP2 signaling pathway activation in HCC78CR1-5 cells, Ba/F3 ROS1 fusion and ROS1-G2032R resistant mutation. Mouse xenograft models with Ba/F3 ROS1 fusion showed more CD3+PD-1+ T cells both in blood and tissue, and more sensitivity than the cells with Ba/F3 ROS1-G2032R resistant mutation after anti-PD-L1 therapy. Our findings indicate that PD-L1 upregulation depends on ROS1 fusion more than ROS1-G2032R mutation. We share our insights of NSCLCs treatment management into the use of anti-PD-L1 ICI therapy in ROS1 fusion and not in ROS1-G2032R resistant mutation.
Stroke-Induced Modulation of Myeloid-Derived Suppressor Cells (MDSCs) and IL-10-Producing Regulatory Monocytes
Authors: Achmus Lennart , Ruhnau Johanna , Grothe Sascha , von Sarnowski Bettina , Bröker Barbara M. , Dressel Alexander , Schulze Juliane , Vogelgesang Antje 
Published: November 2020

Background: Stroke patients are at risk of acquiring secondary infections due to stroke-induced immune suppression (SIIS). Immunosuppressive cells comprise myeloid-derived suppressor cells (MDSCs) and immunosuppressive interleukin 10 (IL-10)-producing monocytes. MDSCs represent a small but heterogeneous population of monocytic, polymorphonuclear (or granulocytic), and early progenitor cells (“early” MDSC), which can expand extensively in pathophysiological conditions. MDSCs have been shown to exert strong immune-suppressive effects. The role of IL-10-producing immunosuppressive monocytes after stroke has not been investigated, but monocytes are impaired in oxidative burst and downregulate human leukocyte antigen—DR isotype (HLA-DR) on the cell surface.Objectives: The objective of this work was to investigate the regulation and function of MDSCs as well as the immunosuppressive IL-10-producing monocytes in experimental and human stroke.Methods: This longitudinal, monocentric, non-interventional prospective explorative study used multicolor flow cytometry to identify MDSC subpopulations and IL-10 expression in monocytes in the peripheral blood of 19 healthy controls and 27 patients on days 1, 3, and 5 post-stroke. Quantification of intracellular STAT3p and Arginase-1 by geometric mean fluorescence intensity was used to assess the functionality of MDSCs. In experimental stroke induced by electrocoagulation in middle-aged mice, monocytic (CD11b+Ly6G−Ly6Chigh) and polymorphonuclear (CD11b+Ly6G+Ly6Clow) MDSCs in the spleen were analyzed by flow cytometry.Results: Compared to the controls, stroke patients showed a relative increase in monocytic MDSCs (percentage of CD11b+ cells) in whole blood without evidence for an altered function. The other MDSC subgroups did not differ from the control. Also, in experimental stroke, monocytic, and in addition, polymorphonuclear MDSCs were increased. The numbers of IL-10-positive monocytes did not differ between the patients and controls. However, we provide a new insight into monocytic function post-stroke since we can report that a differential regulation of HLA-DR and PD-L1 was found depending on the IL-10 production of monocytes. IL-10-positive monocytes are more activated post-stroke, as indicated by their increased HLA-DR expression.Conclusions: MDSC and IL-10+ monocytes can induce immunosuppression within days after stroke.
Can I Discharge My Stroke Patient Home After Inpatient Neurorehabilitation? LIMOS Cut-Off Scores for Stroke Patients “Living Alone” and “Living With Family”
Authors: Ottiger Beatrice , Lehnick Dirk , Pflugshaupt Tobias , Vanbellingen Tim , Nyffeler Thomas 
Published: November 2020

Background: Discharge planning of stroke patients during inpatient neurorehabilitation is often difficult since it depends both on the patient's ability to perform activities of daily living (ADL) and the social context. The aim of this study was to define ADL cut-off scores using the Lucerne ICF-based multidisciplinary observation scale (LIMOS) that allow the clinicians to decide whether stroke patients who “live alone” and “live with a family” can be discharged home or must enter a nursing home. Additionally, we investigated whether age and gender factors influence these cut-off scores.Methods: A single-center retrospective cohort study was conducted to establish cut-off discharge scores for the LIMOS. Receiver-operating-characteristics curves were calculated for both patient groups “living alone” and “living with family” to illustrate the prognostic potential of the LIMOS total score with respect to their discharge goals (home alone or nursing home; home with family or nursing home). A logistic regression model was used to determine the (age- and gender-adjusted) odds ratios of being released home if the LIMOS total score was above the cut-off. A single-center prospective cohort study was then conducted to verify the adequacy of the cut-off values for the LIMOS total score.Results: A total of 687 stroke inpatients were included in both studies. For the group “living alone” a LIMOS total score above 158 indicated good diagnostic accuracy in predicting discharge home (sensitivity 93.6%; specificity 95.4%). A LIMOS total cut-off score above 130 points was found for the group “living with family” (sensitivity 92.0%; specificity 88.6%). The LIMOS total score odds ratios, adjusted for age and gender, were 292.5 [95% CI: (52.0–1645.5)] for the group “living alone” and were 89.4 [95% CI: (32.3–247.7)] for the group “living with family.”Conclusion: Stroke survivors living alone needed a higher ADL level to return home than those living with a family. A LIMOS total score above 158 points allows a clinician to discharge a patient that lives alone, whereas a lower LIMOS score above 130 points can be sufficient in a patient that lives with a family. Neither age nor gender played a significant role.
Development and Testing of a Novel Measure to Assess Fidelity of Implementation: Example of the Mini-AFTERc Intervention
Authors: Brandt Nathalie Georgia , McHale Calum Thomas , Humphris Gerald Michael 
Published: November 2020

BackgroundFidelity of implementation (FOI) reflects whether an intervention was implemented in clinical practice according to the originally developed manual and is a key aspect in understanding intervention effectiveness. To illustrate this process of developing a fidelity measure, this study uses the Mini-AFTERc, a brief psychological intervention aimed at managing breast cancer patients’ fear of cancer recurrence, as an example.ObjectivesTo illustrate the development of an FOI measure through (1) applying this process to the Mini-AFTERc intervention, by including the design of a scoring system and rating criteria; (2) content validating the FOI measure using thematic framework analysis as a qualitative approach; (3) testing consistency of the FOI measure using interrater reliability.MethodsThe FOI measure was developed, its scoring system modified and the rating criteria defined. Thematic framework analysis was conducted to content validate the FOI measure using nine intervention discussions between four specialist cancer nurses and four breast cancer patients, and one simulated breast cancer patient. Intraclass-correlation was conducted to assess interrater reliability.ResultsThe qualitative findings suggested that the Mini-AFTERc FOI measure has content validity as it was able to measure all five components of the Mini-AFTERc intervention. The interrater reliability suggested a moderate to excellent degree of reliability among three raters, rICC = 0.84, 95% CI [0.51, 0.96].ConclusionThe study has illustrated the steps that an FOI measure can be developed through a systematic approach applied to the Mini-AFTERc intervention. The FOI measure was found to have content validity and was consistently applied, independently, by three researchers familiar with the Mini-AFTERc intervention. Future studies should determine whether similar levels of interrater reliability can be obtained by distributing written and/or video instructions to researchers who are unfamiliar with the FOI measure, using a larger sample. Employing developed and validated FOI measures such as the one presented for the Mini-AFTERc would facilitate implementation of interventions in the FCR field in clinical practice as intended.Clinical Trial Registrationwww.ClinicalTrials.gov, identifier: NCT03763825.
COVID-19 Related Distress Is Associated With Alcohol Problems, Social Media and Food Addiction Symptoms: Insights From the Italian Experience During the Lockdown
Authors: Panno Angelo , Carbone Giuseppe Alessio , Massullo Chiara , Farina Benedetto , Imperatori Claudio 
Published: November 2020

Background: Several scholars hypothesize that one of the most negative impacts of the coronavirus disease 2019 (COVID-19) crisis would concern the increase of prevalence and severity of both substances and behavioral addiction. Despite the general concerns about the increase of prevalence and severity of addictions related to the COVID-19 emergency, few data are still available. Thus, the main aim of this study was to investigate the association between COVID-19 related distress and: (i) alcohol problems, (ii) social media addiction (SMA) symptoms, (iii) food addiction (FA) symptoms.Methods: A national online-survey was carried out during the Italian lockdown (i.e., 9 March 2020–4 May 2020). In the current study, 1,519 participants (365 men and 1,154 women, mean age: 28.49 ± 10.89 years) were included. The survey included socio-demographic related items (e.g., age, sex, residential regions, education level, civil status, tobacco use, etc.), as well as ad-hoc developed questions aimed to investigate COVID-19 related variables (e.g., isolation/quarantine, personal diagnosis to COVID-19, friends or relatives with COVID-19 diagnosis, etc.). Participants also completed the following self-report measures in order to investigate: the psychological impact of COVID-19, alcohol problems, SMA symptoms, FA symptoms, and impulsivity.Results: The psychological impact of COVID-19 was independently associated with alcohol problems (β = 0.058, p = 0.043), SMA symptoms (β = 0.259, p &lt; 0.001), and FA symptoms (β = 0.150, p &lt; 0.001).Conclusion: Taken together, our results seem to confirm the general concerns about the negative impacts of the COVID-19 emergency on addictive behaviors, suggesting that this issue should be carefully monitored.
La distribución social de responsabilidades y actuaciones en el desarrollo futuro de la educación en América Latina
Authors: Romero Lozano Simón 
Published: November 2020

En este trabajo el autor realiza una propuesta prospectiva en torno a la distribución social de responsabilidades en el futuro de la educación. El análisis parte de la base de que, si se tiene en cuenta la enorme diversidad de tareas y requerimientos, la distribución social de atribuciones y actuaciones no podrá ser asumida en exclusiva por el Estado. Las corrientes neoliberales postulan una disminución del tamaño del Estado, pero esto no puede entenderse como una superposición del mismo sobre la sociedad civil. Por el contrario, ambos ámbitos deben afrontar conjuntamente un doble desafío, que incluye la atención de necesidades básicas y la mejora en la calidad de la educación. Delimitando fronteras de actuación, Estado y sociedad civil podrán abordar con garantías los requerimientos vinculados al futuro desarrollo tecnológico.
Guardar
Principales tendencias y modelos de la educación ambiental en el sistema escolar
Authors: González Muñoz María del Carmen 
Published: November 2020

La finalidad de este trabajo es presentar los orígenes y planteamientos básicos con que surgió y ha ido desarrollándose la Educación Ambiental, su conceptualización actual y las características con que se configura en el sistema educativo. Se analizan también las condiciones necesarias para que esta Educación pueda integrarse en la escuela y en las diferentes etapas educativas y los modelos con que tal integración se ha producido y se está produciendo en los distintos países.
Estudio especial merece la opción sobre cuya mayor pertinencia parece existir amplio consenso: la «ambientalización» del currículo y la transversalidad, analizándose las características de un diseño curricular de esta índole.
La participación del alumnado en los institutos de educación secundaria: una aproximación a su realidad
Authors: Velázquez Buendía Roberto 
Published: November 2020

A lo largo de los últimos años, el discurso sobre la importancia de la participación de los diferentes sectores de la comunidad educativa en el funcionamiento de las instituciones escolares ha ido ganando fuerza, tanto desde el punto de vista normativo como desde la perspectiva del análisis teórico y axiológico.
En el marco de renovación y de profundos cambios en que se halla inmerso actualmente el sistema educativo en España —cambios que comenzaron hace más de una década y que, según las previsiones, se extenderán hasta el final del presente siglo—, la ley orgánica que regula el Derecho a la Educación (L.O.D.E., 1985) ha supuesto una nueva forma de concebir la organización y gestión de centros docentes, confiriendo a los diversos sectores de la comunidad educativa la capacidad y el derecho de intervenir en muchos e importantes aspectos de la vida cotidiana de la institución escolar.
Diversidad cultural y educación en Iberoamérica
Authors: Díaz-Couder Ernesto 
Published: November 2020

Cuando se trata de formular un perfil de los pueblos amerindios, las más de las veces el retrato resultante es el de la carencia; carencia de recursos económicos y materiales, carencia de condiciones de higiene y sanitarias adecuadas, carencia de educación (y por tanto deficitarios culturalmente), e incluso carencia idiomática («ni siquiera hablan español» o «lo que hablan no es un idioma, es un dialecto»). De este modo la carencia aparece como uno de los rasgos principales de la indianidad.
Aparece así una ecuación que se repite constantemente: pueblos indígenas=pueblos indigentes. De ahí que atender la especificidad cultural de los pueblos indígenas se transforme en combate a su pobreza. Ser «indio» es ser pobre; al dejar de ser pobre se deja de ser «indio», e igualmente dejar de ser «indio» es un indicador de que se está dejando de ser pobre. Así, en función de esa insostenible ecuación ideológica, la indispensable lucha contra la pobreza se convierte en una legítima justificación para acabar con las culturas indígenas.
El papel de la educación ante las transformaciones científico-tecnológicas
Authors: Gil Pérez Daniel 
Published: November 2020

La discusión acerca del papel de la educación ante las transformaciones científico-tecnológicas aparece como una cuestión esencial para analizar los cambios educativos que se consideran necesarios hoy en la región… y en el resto de nuestro cada vez más globalizado planeta.Se trata de una discusión esencial, decimos, porque las transformaciones educativas son una exigencia, en buena medida, del actual desarrollo científico-tecnológico. Se trata, además, de una discusión urgente, pues el sistema educativo se caracteriza por una fuerte inercia que dificulta su adaptación a una realidad cambiante, y esa inercia puede resultar particularmente grave en un momento en el que las transformaciones científico-tecnológicas han adquirido una aceleración que está modificando profunda y permanentemente nuestras vidas (Ramonet, 1997).
Aproximación a la educación infantil: características e implicaciones educativas
Authors: Vila Ignasi 
Published: November 2020

En palabras del propio autor «…la educación infantil tiene tres actores: niños y niñas, familias y profesionales de la educación… La práctica en la educación infantil no se puede realizar al margen de la familia». Por ello, «la educación infantil (debe ser) una forma de apoyo social para (el mejoramiento de) las prácticas educativas familiares», teniendo en cuenta que «por si misma no elimina las diferencias socioculturales…, si bien ayuda a ello».
«La educación infantil… debe entenderse como un derecho —no como una obligación— que tiene toda la infancia a poder participar en situaciones educativas, distintas a la familiar, que sirvan para promover su desarrollo».
Estos son algunos de los principales elementos en los que se basa Ignasi Vila para sostener la tesis de que «… la naturaleza y las características de la educación infantil obligan a una práctica educativa innovadora, adaptada a los cambios sociales y, por tanto, fuente de cambios para el conjunto del sistema educativo».