bluuebunny/crossref_metadata_2025_split huggingface dataset:
A transformative learning journey of a teacher educator in enacting an activist approach in Physical Education Teacher Education
Authors: Luguetti Carla , Oliver Kimberly L. 
Published: September 2020

Over the past decades, a body of scholarship has highlighted the benefits of an activist approach in Physical Education Teacher Education (PETE). This body of research shows that an activist approach enables teacher educators, student teachers and young people to work together in order to become conscious of the power structures in society that lead to social inequities. Although we have a body of research on social justice and critical pedagogy in PETE, there is much to learn about physical education teacher educators’ learning journeys in enacting activist approaches. By using a critical autoethnography approach, this study explores a transformative learning journey experienced by the lead author in enacting an activist approach based on young people’s voices. The PETE educator’s learning journey emerged from the reflexive process in the last 8 years with the second author. A critical theoretical framework based on critical pedagogy and feminist studies is employed to discuss the transformative learning journey presented in this paper. By establishing a collective meaning, we aim to provide rich instances of critical pedagogies that add to the project of identifying various approaches to social justice in PETE contexts. This is a relevant story to PETE practitioners who might be attempting to take a critical stance in contemporary university contexts.
Balloon aortic valvuloplasty for urgent treatment of severe aortic stenosis during coronavirus disease 2019 pandemic: a case report
Authors: Attisano Tiziana , Silverio Angelo , Bellino Michele , Tumscitz Carlo , Tarantino Fabio Felice , Santarelli Andrea , Baldi Cesare , Citro Rodolfo , Galasso Gennaro 
Published: September 2020

AbstractAn 86‐year‐old man affected by severe aortic stenosis (AS) was referred to our institution owing to decompensated heart failure. Three months before, the patient was scheduled for transcatheter aortic valve implantation (TAVI), which was postponed owing to the coronavirus disease 2019 (COVID‐19) outbreak. Owing to COVID‐19 suspicion, he underwent nasopharyngeal swab and was temporarily isolated. However, the rapid deterioration of clinical and haemodynamic conditions prompted us to perform balloon aortic valvuloplasty (BAV) as bridge to TAVI. The patient's haemodynamics improved; and the next day, the reverse transcriptase–polymerase chain reaction for COVID‐19 was negative. At Day 5, he underwent TAVI procedure. Subsequent clinical course was uneventful. During COVID‐19 pandemic, the deferral of TAVI procedure should be assessed on a case‐by‐case basis to avoid delay in patients at high risk for adverse events. BAV may be an option when TAVI is temporarily contraindicated such as in AS patients suspected for COVID‐19.
Coronary microvascular dysfunction is associated with exertional haemodynamic abnormalities in patients with heart failure with preserved ejection fraction
Authors: Ahmad Ali , Corban Michel T. , Toya Takumi , Verbrugge Frederik H. , Sara Jaskanwal D. , Lerman Lilach O. , Borlaug Barry A. , Lerman Amir 
Published: September 2020

AimsThis study uniquely explored the relationship between coronary microvascular function and exercise haemodynamics using concurrent invasive testing.Methods and resultsFifty‐one consecutive patients with unexplained cardiac exertion symptoms, non‐obstructive coronary artery disease and normal left ventricular ejection fraction (>50%) underwent haemodynamic exercise assessment and concurrent coronary reactivity testing. Heart failure with preserved ejection fraction (HFpEF) was defined as a pulmonary arterial wedge pressure (PAWP) ≥15 mmHg at rest and/or ≥25 mmHg at peak exercise. Endothelium‐independent coronary microvascular dysfunction (CMD) was defined as a coronary flow reserve (CFR) ≤2.5, while endothelium‐dependent CMD was defined as ≤50% increase in coronary blood flow (CBF) in response to intracoronary acetylcholine infusions. Patients with HFpEF (n = 22) had significantly lower CFR (2.5 ± 0.6 vs. 3.2 ± 0.7; P = 0.0003) and median %CBF increase in response to intracoronary acetylcholine [1 (−35; 34) vs. 64 (−4; 133); P = 0.002] compared to patients without HFpEF (n = 29). PAWP was significantly higher in patients with endothelium‐independent CMD compared to controls during both rest and exercise. This significant elevation was only present during exercise in patients with endothelium‐dependent CMD compared to controls. CFR had significant inverse correlations with PAWP at rest (r = −0.31; P = 0.03) and peak exercise (r = −0.47, P = 0.001). CFR also had positive correlations with maximal exercise capacity (in W/kg) (r = 0.33, P = 0.02).ConclusionsCoronary microvascular function is inversely associated with filling pressures, particularly during exercise. Both types of CMD are associated with higher filling pressures at peak exercise. These findings underscore the potential mechanism and therapeutic target for CMD and HFpEF.
Wave direction shift triggered severe erosion of beaches in estuaries and bays with limited post‐storm recovery
Authors: Gallop Shari L. , Vila‐Concejo Ana , Fellowes Thomas E. , Harley Mitchell D. , Rahbani Maryam , Largier John L. 
Published: September 2020

AbstractMany estuaries contain sandy beaches that provide habitats and offer protective buffers for wetlands and infrastructure, alongside cultural and recreational resources. Research underpinning coastal management tends to focus on tide‐ and swell‐dominated sandy beaches, but little attention is given to beaches in estuaries and bays (BEBs) that exist along a continuum of wind/swell wave, tide and riverine influence. BEBs are subject to less wave energy than open coast locations because of the generally narrow window of directions for which ocean waves can propagate through the entrance. However, when storm wave direction coincides with the orientation of the estuary or bay entrance, waves can penetrate several kilometres inside. Here we focus on eight BEBs in two major bays/estuaries in Sydney, Australia and present observations from before and after a major extratropical storm with waves from an atypical direction in June 2016. We quantify magnitudes of beach erosion and recovery rates for 3 years post‐storm. We show that when high‐energy storm waves penetrate bays and estuaries, BEBs can undergo up to 100% of subaerial beach erosion. Three years after the storm, only 5 of the 29 (17%) eroded subaerial beach profiles had recovered to their pre‐storm volume. This is likely due to the lack of low‐frequency, beach‐building waves at BEBs under modal weather conditions in between storms, in contrast to open coast beaches. We also show that the recovery of BEBs may be limited by the absence of adjacent sediment reservoirs due to the dominance of tidal processes mid‐channel. Our study highlights the unique behaviour of BEBs relative to beaches on the open coast, and that shifting wave direction needs to be considered in long‐term beach resilience under climate change. © 2020 John Wiley & Sons, Ltd.
Altered structure and functional connectivity of the hippocampus are associated with social and mathematical difficulties in nonverbal learning disability
Authors: Banker Sarah M. , Pagliaccio David , Ramphal Bruce , Thomas Lauren , Dranovsky Alex , Margolis Amy E. 
Published: September 2020

AbstractThe hippocampus is known to play a critical role in a variety of complex abilities, including visual‐spatial reasoning, social functioning, and math. Nonverbal learning disability (NVLD) is a neurodevelopmental disorder characterized by deficits in visual‐spatial reasoning that are accompanied by impairment in social function or mathematics, as well as motor or executive function skills. Despite the overlap between behaviors supported by the hippocampus and impairments in NVLD, the structure and function of the hippocampus in NVLD has not been studied. To address this gap in the literature, we first compared hippocampal volume and resting‐state functional connectivity in children with NVLD (n = 24) and typically developing (TD) children (n = 20). We then explored associations between hippocampal structure, connectivity, and performance on measures of spatial, social, and mathematical ability. Relative to TD children, those with NVLD showed significant reductions in left hippocampal volume and greater hippocampal‐cerebellar connectivity. In children with NVLD, reduced hippocampal volume associated with worse mathematical problem solving. Although children with NVLD exhibited more social problems (social responsiveness scale [SRS]) and higher hippocampal‐cerebellar connectivity relative to TD children, greater connectivity was associated with fewer social problems among children with NVLD but not TD children. Such an effect may suggest a compensatory mechanism. These structural and functional alterations of the hippocampus may disrupt its putative role in organizing conceptual frameworks through cognitive mapping, thus contributing to the cross‐domain difficulties that characterize NVLD.
Humanized anti‐CD19 chimeric antigen receptor‐T cell therapy is safe and effective in lymphoma and leukemia patients with chronic and resolved hepatitis B virus infection
Authors: Cui Rui , Lyu Cuicui , Li Qing , Jiang Yanyu , Mou Nan , Yang Zhenxing , Liu Xuxiang , Deng Qi , Li Lanfang 
Published: September 2020

AbstractChimeric antigen receptor‐T (CAR‐T) cell therapy is a promising treatment for CD19+ B‐cell malignancies. However, elimination of B cells by anti‐CD19 CAR‐T cells may lead to the reactivation of hepatitis B virus (HBV) and related hepatitis in patients with HBV infection. This study aims to evaluate the safety and efficacy of humanized anti‐CD19 CAR‐T (hCAR‐T) therapy in B‐cell malignancies with HBV infection. Twenty relapsed/refractory (r/r) diffuse large B‐cell lymphoma (DLBCL) and acute lymphoblastic leukemia (ALL) patients with HBV infection were treated with hCAR‐T therapy. Among them, five hepatitis B antigen‐positive patients who received antiviral prophylaxis did not develop HBV reactivation, including two patients who received both hCAR‐T and allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Among 15 patients with resolved HBV infection, two received antiviral prophylaxis, and the other 13 did not experience HBV reactivation without antiviral prophylaxis. One patient with resolved HBV infection experienced HBV reactivation 6 months after hCAR‐T therapy and sequential allo‐HSCT. Moreover, HBV infection did not affect in vivo expansion of hCAR‐T cells or increase the risk of severe cytokine release syndrome. In conclusion, hCAR‐T therapy is safe and effective in DLBCL and ALL patients with chronic and resolved HBV infection under proper antiviral prophylaxis.
Ecohydrological responses to surface flow across borders: Two decades of changes in vegetation greenness and water use in the riparian corridor of the Colorado River delta
Authors: Nagler Pamela L. , Barreto‐Muñoz Armando , Chavoshi Borujeni Sattar , Jarchow Christopher J. , Gómez‐Sapiens Martha M. , Nouri Hamideh , Herrmann Stefanie M. , Didan Kamel 
Published: September 2020

AbstractHydrological and bioclimatic processes that lead to drought may stress plants and wildlife, restructure plant community type and architecture, increase monotypic stands and bare soils, facilitate the invasion of non‐native plant species and accelerate soil erosion. Our study focuses on the impact of a paucity of Colorado River surface flows from the United States (U.S.) to Mexico. We measured change in riparian plant greenness and water use over the past two decades using remotely sensed measurements of vegetation index (VI), evapotranspiration (ET) and a new annualized phenology assessment metric (PAM) for ET. We measure these long‐term (2000–2019) metrics and their short‐term (2014–2019) response to an environmental pulse flow in 2014, as prescribed under Minute 319 of the 1944 Water Treaty between the two nations. In subsequent years, small‐directed flows were provided to restoration areas under Minute 323. We use 250 m MODIS and 30 m Landsat imagery to evaluate three vegetation indices (NDVI, EVI, EVI2). We select EVI2 to parameterize an optical‐based ET algorithm and test the relationship between ET from Landsat and MODIS by regression approaches. Our analyses show significant decreases in VIs and ET for both the 20‐year and post‐pulse 5‐year periods. Over the last 20 years, EVI Landsat declined 34% (30% by EVIMODIS) and ETLandsat‐EVI declined 38% (27% by ETMODIS‐EVI), overall ca. 1.61 mm/day or 476 mm/year drop in ET; using PAM ETLandsat‐EVI the drop was from 1130 to 654 mm/year. Over the 5 years since the 2014 pulse flow, EVILandsat declined 20% (13% by EVIMODIS) and ETLandsat‐EVI declined 23% (4% by ETMODIS‐EVI) with a 0.77 mm/day or a 209 mm/year 5‐year drop in ET; using PAM ETLandsat‐EVI the drop was from 863 to 654 mm/year. Data and change maps show the pulse flow contributed enough water to slow the rate of loss, but only for the very short‐term (1–2 years). These findings are critically important as they suggest further deterioration of biodiversity, wildlife habitat and key ecosystem services due to anthropogenic diversions of water in the U.S. and Mexico and from land clearing, fires and plant‐related drought which affect hydrological processes.
Post‐GWAS Polygenic Risk Score: Utility and Challenges
Authors: Nguyen Tuan V , Eisman John A 
Published: September 2020

ABSTRACTOver the past decade, through genome‐wide association studies, more than 300 genetic variants have been identified to be associated with either BMD or fracture risk. These genetic variants are common in the general population, but they exert small to modest effects on BMD, suggesting that the utility of any single variant is limited. However, a combination of effect sizes from multiple variants in the form of the polygenic risk score (PRS) can provide a useful indicator of fracture risk beyond that obtained by conventional clinical risk factors. In this perspective, we review the progress of genetics of osteoporosis and approaches for creating PRSs, their uses, and caveats. Recent studies support the idea that the PRS, when integrated into existing fracture prediction models, can help clinicians and patients alike to better assess the fracture risk for an individual, and raise the possibility of precision risk assessment. © 2020 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
Therapeutic plasma exchange with standard hemodialysis machine as an alternative to dedicated apheresis device: A 5‐year experience
Authors: Pongsittisak Wanjak , Satpanich Panchalee , Kurathong Sathit 
Published: September 2020

AbstractPatients suffering from various diseases have been shown to benefit from therapeutic plasma exchange (TPE). However, in developing countries, there are many obstacles hindering the establishment and initiation of TPE programs. These include inadequate funding and lack of government healthcare coverage. Our center in Thailand practices a unique membrane plasma separator technique using a hemodialysis machine incorporated with a plasma separator. Over a 5 year period, there were 130 such sessions conducted in 24 patients. The indications for TPE treatment included neurological, hematological, and nephrological diseases. Overall, response to TPE was good. Some TPE‐related adverse events did occur, but none were life‐threatening. Unfortunately, infection remained a problem and was sometimes a cause of death. Future challenges include minimization of infection rates and making TPE treatment readily accessible to patients.
Elevated carcinoembryonic antigen and bronchial obstruction caused by a rotten vegetable leaf mimic lung cancer: A case report
Authors: Sun Ye , Ge Yan L. , Li Li Q. , Liu Yang , Lu Yang , Jing Qin , Chen Yi , Li Wen Q. , Hou Lin L. , Min Pei 
Published: September 2020

AbstractBackgroundTracheobronchial foreign body aspiration is a potentially risky medical event, while the condition often requires early detection and rapid intervention to improve respiratory symptoms and prevent major morbidity. Notably, foreign bodies may not be identified and they are likely to be mistaken for neoplastic lesions. However, CEA, as one of tumor markers, presents to be available for assisting in lung cancer diagnosis, especially for non–small‐cell lung cancer, while the specificity of CEA is not high.MethodsHere, we described a case of bronchial opening obstruction with elevated carcinoembryonic antigen (CEA) that was firstly misdiagnosed as lung cancer and proved as foreign body aspiration in the upper lobe bronchus of right lung by bronchoscopy.ResultsCarcinoembryonic antigen level increased. CT scan demonstrated a cavitation accompanied by multiple small nodular shadows appeared in the right upper lobe field. Bronchoscopy suggested right upper lobe bronchus was blocked by a brown smooth organism with plenty of purulent materials, which was proved as a rotten vegetable leaf.ConclusionsElevated CEA and bronchial obstruction are not typical manifestations of lung cancer. Bronchoscopy is crucial for making a reliable diagnosis.
Population Pharmacokinetic Analysis for Plasma and Epithelial Lining Fluid Ceftolozane/Tazobactam Concentrations in Patients With Ventilated Nosocomial Pneumonia
Authors: Zhang Zufei , Patel Yogesh T. , Fiedler‐Kelly Jill , Feng Hwa‐Ping , Bruno Christopher J. , Gao Wei 
Published: September 2020

AbstractCeftolozane/tazobactam (C/T) is a combination of a novel cephalosporin with tazobactam, recently approved for the treatment of hospital‐acquired and ventilator‐associated pneumonia. The plasma pharmacokinetics (PK) of a 3‐g dose of C/T (2 g ceftolozane and 1 g tazobactam) administered via a 1‐hour infusion every 8 hours in adult patients with nosocomial pneumonia (NP) were evaluated in a phase 3 study (ASPECT‐NP; NCT02070757). The present work describes the development of population PK models for ceftolozane and tazobactam in plasma and pulmonary epithelial lining fluid (ELF). The concentration‐time profiles of both agents were well characterized by 2‐compartment models with zero‐order input and first‐order elimination. Consistent with the elimination pathway, renal function estimated by creatinine clearance significantly affected the clearance of ceftolozane and tazobactam. The central volumes of distribution for both agents and the peripheral volume of distribution for tazobactam were approximately 2‐fold higher in patients with pneumonia compared with healthy participants. A hypothetical link model was developed to describe ceftolozane and tazobactam disposition in ELF in healthy participants and patients with pneumonia. Influx (from plasma to the ELF compartment) and elimination (from the ELF compartment) rate constants were approximately 97% lower for ceftolozane and 52% lower for tazobactam in patients with pneumonia versus healthy participants. These population PK models adequately described the plasma and ELF concentrations of ceftolozane and tazobactam, thus providing a foundation for further modeling and simulation, including the probability of target attainment assessments to support dose recommendations of C/T in adult patients with NP.
Three‐dimensional power Doppler ultrasonography indicates that increased placental blood perfusion during the third trimester is associated with the risk of macrosomia at birth
Authors: Zhou Jizi , Xiong Yu , Ren Yunyun , Zhang Ying , Li Xiaotian , Yan Yingliu 
Published: September 2020

AbstractPurposeTo investigate the association between placental blood perfusion and the occurrence of macrosomia at birth.MethodsThis was a prospective cohort study including women with singleton pregnancies that aimed to measure placental blood perfusion using three‐dimensional (3D) power Doppler ultrasonography in the second and third trimester. We acquired three indices of placental blood flow, including vascularization index (VI), flow index (FI), vascularization flow index (VFI), along with routine two‐dimensional (2D) biometric measurements, including abdominal circumference (AC) and estimated fetal weight (EFW). Pregnancy outcomes were divided into two groups: newborns with a normal birth weight and those with macrosomia. We then compared all of the recorded variables between these two groups. We also determined the predictive efficiency of each variable using receiver‐operating characteristic (ROC) curves.ResultsThe placental 3D power Doppler indices, including VI and FI, were significantly higher in the third trimester of pregnancies developing macrosomia, but not during the second trimester, as compared to those with a normal birth weight. ROC curves analysis for third‐trimester VI and FI suggested a slight ability to predict macrosomia; this was also the case for AC and EFW. Interestingly, VI showed high sensitivity and low specificity, while FI showed low sensitivity and high specificity; this was also the case for AC and EFW.ConclusionsThree‐dimensional power Doppler ultrasound indices were significantly higher during the third‐trimester for pregnancies developing macrosomia. However, these indices had only moderate ability to predict macrosomia.
Dental students’ perception about using videos in teaching professionalism: A Saudi Arabian experience
Authors: Al‐Khalifa Khalifa S. , Gaffar Balgis O. 
Published: September 2020

AbstractObjectiveTo describe the development and evaluation of using videos (watched and student‐generated) for teaching stronger interpersonal communication skills to dental students.MethodologyWe used the Experiential Learning Theory to develop a professionalism course for third‐year dental students. Videos were used as the core method of teaching communication skills. Students were guided to produce videos that addressed an array of communication scenarios. Quantitative data was collected using a Likert‐scale questionnaire to assess students’ perceptions about watching and generating videos. The questionnaire was divided into 3 parts: the first part assessed students’ perceptions and skills gained when producing videos. The second part assessed students’ perceptions about watching videos to gain knowledge. The last part assessed their perceptions about their overall learning experience.ResultsA total of 110 students, 50 males and 60 females, were enrolled in the course. Developing team skills and a better understanding of professional communication with patients were acknowledged by 85% and 80% of students respectively during video production. Improved problem‐solving skills were reported by 77% students while involved in video production. While watching motivational interviewing strategies and interpersonal skills videos, 86% stated that watching the videos improved their understanding of professional behavior with colleagues. Only 33% felt that they had enough time to prepare videos and only 38% were willing to prepare videos in the future.ConclusionUsing videos in teaching communication skills was found effective. Producing videos had more benefits than simply watching videos. Caution should be given when allocating time for such activities.