bluuebunny/crossref_metadata_2025_split huggingface dataset:
TATA SPASIAL ARSITEKTUR TRADISIONAL SUKU ATONI DI KAMPUNG TAMKESI PULAU TIMOR
Authors: Lake Reginaldo Ch. 
Published: June 2020

Title: Spatial Planning of Tradisional Architecture as Observed among the Atoni Tribe in the Tamkesi Kampong on Timor Island
This research aims to investigate the concept of spatial planning found in the traditional architecture of the Atoni tribe living in the traditional kampong of Tamkesi on Timor Island. The method employed for this research project consists of the following steps: first of all, to record and re-sketch the entire physical state of this kampong in the greatest possible detail. The result of these sketches is subsequently subjected to an anatomical analysis to arrive a classification of the relationship between all of the elements encountered and scrutinized; secondly, to make an analysis by exposing the latter to the principles of identification and orientation. The analysis is based on an elaboration of the phenomenological approach by Norberg-Schulz and the structural approach involving function-form-meaning by Salura.
Based on the outcome of this analysis, the local concept serves as the basis for the spatial planning of traditional architecture as observed in the Tamkesi kampong. The conclusion drawn reveals that the relationship between the immediate environment, the site, form, framwork and the natural-cultural cycle in traditional architecture is clearly influenced by the concept of top-down (upper vs. lower) hierarchy as well as the binding element (datum) of the tribal order (hierarchy, the gender code/etiquette, ethnic bonds and traditional customs as well as cultural and spiritual symbols).
PERUBAHAN FISIK-SPASIAL PADA SKALA MIKRO DAN MESO KAMPUNG PULAU BELIMBING
Authors: Al Husaini Muhd. Arief 
Published: June 2020

Title: Physical-spatial Changes on Mikro and Meso Scales in Pulau Belimbing Village
Pulau Belimbing is an old village in Riau province. There are some tribes live in this village such as Malay, Domo, Caniago, Piliang, and Pitopang. Village space formed based on the rule of tribe through discussion. The rule determines layout of space, fuction, and ownership. Each tribe will live in their area. Besides, village has some public area that it can used by all tribe. The rule makes the village identity differs with others village. Nowadays, the rule of village space was changing. The changes is showed on micro (house) and meso (dwelling) scale. So that, the purpose of this study is to identify the pattern of changes. This research type is desciptive qulitative in which uses historical method. The firts, finding data and fact in research area. The second, interpretation and analysis data and fact. On this research was finding several changes in micro scale such as the changing of dwelling tribe, land use and spatilal of vilage. Then the changing in micro scale such as house type becoming landed house with new material. This result can be use as restoration base of Pulau Belimbing village.
HUBUNGAN KONSEP SETING FISIK DAN KONSEP PERILAKU DI AREA DEPAN GEDUNG REKTORAT Studi Kasus: Universitas Negeri Yogyakarta
Authors: Kristiadi Adimas 
Published: June 2020

Title: The Relation of Physical Setting Concept and Behavior Concept in the Front of Rectorate Building, Case Study: Yogyakarta State University
Students are the "actors" in the university because of their activities. Students need a certain space in the environment around the university. It becomes interesting when students do their activities around the building that is also the environment for rector and university employees, those happened at the area in front of Yogyakarta State University (UNY) rectorate building. There was a cozy quality (fit) space in there based on perception (cognition and schemata) and adaptation of UNY students for area of the UNY rectorate building. There were some quality factors (property) which is included as environment (physical setting) that affect the activity (behavior) of UNY students. The correlation between activity (behavior pattern) and specific environmental order (physical setting) interpreted as behavior setting. The method used is deductive-qualitative with rationalist paradigm. The data obtained were the result of observation, behavior mapping, interviews, questionnaires, with induction analyzed. The results are: 1) the vertical property provided physical comfort and social comfort; 2) the proximity property provided environmental comfort; 3) the artificial lighting distribution property provided social comfort; 4) the property of which describes the situation of natural protection provided physical comfort and environmental comfort.
PENGEMBANGAN DESAIN KURSI TAMAN BUNGKUL DENGAN MENGANGKAT TEMA SPARKLING SURABAYA
Authors: Ramadhani Suci 
Published: June 2020

Title: Design Development of Bungkul Park Street Furniture Related to Sparkling Surabaya Theme
City Park is an open green space that serves as the city's lungs and reduce the pollution and noise, and also can be a gathering place for city residents. In addition to the technical function and social function,a city park in Surabaya also raised Surabaya's image as a City which has 1001 parks. Bungkul Park is located in Darmo Street, this park is not only crowded, but also become one of an icon in Surabaya. Surabaya, which has made Sparkling Surabaya Theme became a brand since 2006, less contribute to the street furniture's design in the main streets of Surabaya and city parks. This is very unfortunate that it can be one of Surabaya's promotional event in national and international. The method of this research used comparative descriptive method, which make a systematic description, factual, and accurate about the facts and circumstances object of investigation that was followed by a comparative study to understand the interrelationships among facts. From the analysis conducted, either through observation, comparison of products, as well as literature study, the data showes that Surabaya Sparkling's elements contains typography, color and lighting factors. The final design of this research is a design of the street furniture of the park related to Sparkling Surabaya theme.
STUDI POSKOLONIAL TERHADAP KAWASAN ALUN-ALUN JEMBER: USAHA MENGGALI POTENSI KOTA KREATIF
Authors: Widriyakara Y.A. , Hidayat Anas , Trisjanti Lucia Ina 
Published: June 2020

Title: Postcolonial Study towards Jember Alun-alun Area: Efforts to Explore the Potential of Creative City
The Alun-alun is an important area in the city in Java, which has existed since pre-colonial era (can be traced back to the Majapahit era), which was later adapted creatively by the Dutch in colonial era to the post-independence of Indonesia. Studies on the Alun-alun is mostly done historically, symbolic or functional, whereas this study viewed from the perspective of postcolonial, that reverse point of view: from the square is considered passive and influenced, being square is active and can be aligned with the global trend. The research method is qualitative research, with a view creativity of Jember society in the process of changes. This study combines direct observation, observe documents and interview. Alun-alun became a media of "control" by the Dutch (towards Indonesian/Jember society) to the New Order era (towards the people of Indonesia/Jember), society is assumed to be liyan (others). Then look for new forms to imitate and reverse of what has been done by the "authorities" so that an alun-alun will be hybrid, diaspora and transculturation also occur. Jember alun-alun area from postcolonial view has a dynamic and adaptive character. Community and Jember alun-alun are not a passive entity that is marginalized and only accept influence from the outside, but they are the subject of the creative changes, to be aligned with a more advanced entity.
POTENSI PENGEMBANGAN BLOK SEGITIGA TUNJUNGAN SEBAGAI BAGIAN DARI PEMBENTUK CITRA KOTA
Authors: Redyantanu Bramasta Putra 
Published: June 2020

Title: Potential Development of Tunjungan Triangle Blocks As Part of Image of The CityMaker
Good urban space is created from a good urban planning also. In the planning phase of the city, it is simulated how a good city consists of well synchronized urban components. Tunjungan, as one of the important formers of Surabaya character, is the most dynamic developed block. The gap between good planning and real condition, was become larger due to partially development. The diversity of land ownership, the capabilities of each developer and so on, are some of the causes. Yet the success of an urban architectureis affected by the ability of spatial planning and city planning collectively.Integrated development involving all aspects of urban space constituency is something that is expected to happen. This study attempted to read the conditions of the triangular block of Tunjungan from urban planning theory perspectives, then reflected on the real conditions in the field. The goal is to get a recommendation based on the development potential of urban elements that will strengthen the identity of the city of Surabaya itself.
KAJIAN KONSEP EKOLOGIS PADA GEDUNG PERPUSTAKAAN PUSAT UGM
Authors: Adi Alifiano Rezka 
Published: June 2020

Title: The Study of Ecological Concept in the Central Library of Gadjah Mada University
Ecological architecture becomes one of the concept as well as solutions in the building design which minimizes environmental damages and maintains the quality of human life. The central library of Gadjah Mada University in Yogyakarta is used as the research object to rate its ecological level. This study uses a quantitative method to rate its ecological level based on the ecological design principles of Sim Van der Ryn such as ecological accounting, design with nature, and making nature visible. The assessment parameters are based on some references such as the greenship of GBCI, the principles of tropical architecture, and the principle of building accessibility. The results showed that generally, the library has applied ecological concept well through some strategies such as extensive greening, energy efficiency, adequate natural lighting, slim building masses, shading elements, and some facilities for the difable. Some measurements are done to find out the ecological performance of the building such as energy efficiency by 39.17%; daylighting 300 lux at 60.67% of indoor area, visualization of solar radiation reception, and OTTV value by 19,85 watt/m2. However, there are some necessary evaluations such as leakage on the ceiling or the application of greenroof that can be further optimized.
Oleamide in Ipomoea and Dillenia Species and Inflammatory Activity Investigated through Ion Channel Inhibition
Authors: Ameamsri Unchaleeporn , Chaveerach Arunrat , Sudmoon Runglawan , Tanee Tawatchai , Peigneur Steve , Tytgat Jan 
Published: June 2020

Background:
Oleamide is an essential substance for human health. So, the plants with high
oleamide content are great sources for health care products.

Objective:
This study is conducted to investigate the quality of oleamide in plants and test the bioactivity
in the selected two studied species.

Methods:
The three Ipomoea and five Dillenia species including Ipomoea alba, Ipomoea aquatica and
Ipomoea pes-caprae, and Dillenia indica, Dillenia obovata, Dillenia ovata, Dillenia parviflora and
Dillenia pentagyna were investigated for the quantity of oleamide by high-performance liquid chromatography.
The biological activity test was conducted on the powder formulation of the chosen plants,
Dillenia ovata and Dillenia parviflora at a ratio of 30:70, for anti-inflammatory activity ex vivo on a
panel of molecular targets through ion channel inhibition including voltage-gated sodium channel,
voltage-gated potassium channel, and the cardiac ion as human ether-a-go-go related gene.

Results:
The results showed that the leaf extracts of I. aquatica and D. ovata gave the highest and subsequent
oleamide quantity i.e. 7.52 and 5.17 mg/g, respectively. Out of the Dillenia formulation which
contained various compounds, oleamide showed the highest percentages of inhibition at 8.0-20.0%,
and 6.2-14.2% in voltage-gated sodium channel, and voltage-gated potassium channel which had
slightly lower values than the oleamide standard, and no effect as 0.0% value inhibition in the cardiac
ion channel.

Conclusion:
The Dillenia formulation exhibits anti-inflammatory activity without affecting the heart.
Accordingly, the three studied Ipomoea and three studied Dillenia species may be used for the same
activity as a single component or formulation with effective solvent for disease treatments.
Nanoparticle Based Gene Therapy Approach: A Pioneering Rebellion in the Management of Psychiatric Disorders
Authors: Rehman Saleha , Nabi Bushra , Pottoo Faheem Hyder , Baboota Sanjula , Ali Javed 
Published: June 2020

:
The neuropsychiatric illnesses have been enigmatic, with no effective treatment to date.
The complexity and heterogeneity of psychiatric disorders are daunting for the development of novel
treatment modalities. The conventional treatment approaches are less effective and are associated with
several side effects, thus creating the need for the development of more innovative strategies. Since
psychiatric disorders are known to exhibit genetic linkage, gene therapy has created an interest among
the researchers worldwide. The delivery of nucleic acids is a complex process requiring the transport
of genetic material across various intracellular and extracellular barriers to reach the target cells
eliciting the transfection process. Therefore, the identification or development of the delivery system
for nucleic acid delivery still remains the challenge. Viral vectors are quite effective but are associated
with toxicity and side effects. With the rapid advancement in the field of nanotechnology, nanosized
materials were identified to be the perfect candidate for nonviral vectors in gene delivery. The biggest
advantage of nanoparticles is that their surface can be engineered in many possible ways to deliver the
drugs directly to the target site. Although gene therapy has already been established as an innovative
treatment modality for several neurological diseases, its use in psychiatry still warrants more
investigations for its translation into clinical use. The present manuscript discusses the prospects of
gene therapy in psychiatric disorders, their benefits, and pitfalls. The review embarks upon the
importance of nanoparticle-based gene therapy for effective management of psychiatric disorders.
Can the Lewis Basicity of an Isolated Solvent Molecule be Used for Characterizing Solvent Effects?
Authors: Gal Jean-François , Maria Pierre-Charles 
Published: June 2020

Background:
The ubiquitous Lewis acid/base interactions are important in solution processes.
Analytical chemistry may benefit from a better understanding of the role of Lewis basicity at
the molecular level or acting through a bulk solvent effect.

Objective:
To delineate (i) the basicity at a molecular level, hereafter referred to as solute basicity,
and (ii) the solvent basicity, which is a bulk-liquid property.

Methods:
The literature that relates Lewis basicity scales and solvent effects is analyzed. A special
focus is placed on two extensive scales, the Donor Number, DN, and the BF3 Affinity scale, BF3A,
which were obtained by calorimetric measurements on molecules as solutes diluted in a quasi-inert
solvent, and therefore define a molecular Lewis basicity. We discuss the validity of these solute
scales when regarded as solvent scales, in particular when the basicity of strongly associated liquids
is concerned.

Results:
We demonstrate the drawbacks of confusing the Lewis basicity of a solvent molecule, isolated
as a solute, and that of the bulk liquid solvent itself.

Conclusion:
Consequently, we recommend a reasoned use of the concept of Lewis basicity taking
clearly into account the specificity of the process for which a Lewis basicity effect may be invoked.
In particular, the action of the Lewis base, either as an isolated entity or as a bulk liquid, must be distinguished.
Nanoparticles and Significance of Photocatalytic Nanoparticles in Wastewater Treatment: A Review
Authors: Sagir Muhammad , Tahir Muhammad B. , Akram Jehangir , Tahir Muhammad S. , Waheed Usama 
Published: June 2020

Background:
In the present situation where there is a water shortage globally, nanoparticles
can play a vital role in treating wastewater to make it usable for several processes. Industrial
wastewater contains numerous heavy metals and associated wastes that enter our food chain by one
means or other. This article provides a review of applications of nanoparticles in wastewater treatment
and highlights the significance of photocatalytic nanoparticles in general.

Methods:
Online journals and books related to wastewater treatment using nanoparticles are reviewed
to compile their essentials findings. General mechanisms, applications, limitations, and comparison
of photocatalytic nanoparticles are reviewed as well.

Results:
A study of photocatalytic nanoparticles shows that TiO2 and ZnO nanoparticles have excellent
photocatalytic capabilities as compared to other nanoparticles due to their bandgap properties;
however, the usage of these nanoparticles is limited since there is higher recombination rate of electrons
and holes in photocatalysis. Further, individual limitations also exist as TiO2 is inoperable in
the visible light region. So, their heterostructures with other nanoparticles have been developed to
overcome their limitations. Other nanoparticles, like noble metals, and those like CuO, CeO2, SnO2
have potential in carrying out photocatalytic degradation of contaminants of wastewaters.

Conclusion:
Several contaminants can be eliminated from wastewater bodies using photocatalytic
nanoparticles. The efficiency of photocatalytic nanoparticles can be enhanced by coupling them with
suitable species. Research in this area can prevent the water shortage of upcoming years.
Modified Plasma Cytokine Profile in Occupational Dermatitis
Authors: Rascu Alexandra M. , Otelea Marina R. , Mambet Cristina , Handra Claudia , Neagu Ana I. , Rascu Agripina , Giurcaneanu Calin , Diaconu Carmen C. 
Published: June 2020

Background:
Despite significant progress in the diagnosis of contact dermatitis, the identification
by specific tests or biomarkers remains an unsolved issue, particularly when needed for the
confirmation of the occupational origin of the disease.

Objective:
To characterize the plasma proteome profile in occupational dermatitis in workers of paint
industry.

Methods:
The study has a case-control design, comparing exposed workers with and without occupational
contact dermatitis, matched for age, gender, occupational history, and comorbidities. An immunological
assay (Human XL Cytokine Array Kit – ARY022B, R&D Systems) was used to measure the
plasma levels of 105 cytokines and chemokines in a pooled sample of the cases and a pooled sample of
the controls.

Results:
A 1.5-fold increase was noticed for interleukin 3, interleukin 10, and leptin in cases, as compared
to controls. Fibroblast growth factor-7 and growth/differentiation factor-15 showed a 1.4-fold
increase, while interleukin 19, interleukin 31, and macrophage inflammatory protein 3 a had only a 1.3-
fold increase. The leukemia inhibitory factor was the only plasma cytokine that showed a 1.3-fold decrease.
All other cytokines had a variation of less than 1.2-fold between cases and controls.

Conclusion:
The recognition of the molecular signatures is very important for an accurate and indisputable
diagnosis of occupational contact dermatitis. In workers from the paint industry, plasma levels
of interleukins 3, 10, 13 and 19, fibroblast growth factor-7, and growth/differentiation factor-15, together
with leukemia inducible factor, may differentiate subjects with contact dermatitis from those
without skin lesions.
Thermo-mechanical Characterization of Insulating Bio-plasters Containing Recycled Volcanic Pyroclasts
Authors: Contrafatto Loredana , Gazzo Salvatore , Purrazzo Antonio , Gagliano Antonio 
Published: June 2020

Aim:
The research proposes the reuse of volcanic wastes in the production of lightened and insulating bio-plasters.

Introduction:
The goal is the production of a novel sustainable construction material that reduces the environmental impact.

Methods:
Four mixtures were designed. The recycled Volcanic Ash was used in combination with two bio-compatible binders; basically Natural Hydraulic Lime (NHL) or calcium hydroxide blended with a commercial Portland cement (CH-CEM). To improve thermal properties, CH-CEM mixtures were treated with an Air Entraining Agent (AEA) in two different percentages and a breathable resin (R). The main physical, mechanical and thermal properties were experimentally determined.

Results:
The results of such analysis indicate that the mixture NHL, realized using hydraulic lime as a binder, do not satisfy the threshold of the water absorption coefficient, exceeding the limit established by UNI EN 998-1 standard.

Conclusion: On the contrary, one of the mixtures CH-CEM, containing both AEA and R, is suitable for use as lightweight plastering mortar and also satisfies the requirements for insulating mortars.
Simultaneous Determination of Telmisartan and Pitavastatin Calcium in Intestinal Perfusate by HPLC: Application to Intestinal Absorption Interaction Study
Authors: Wang Junying , Liu Juan , Song Xiangrong , Fu Chunmei 
Published: June 2020

Background:
Hypertension and hypercholesterolemia are two main physiological
risk factors of cardiovascular disease, and commonly occur in combination. Multicompound
combination therapy is rational for the treatment of concurrent hypertension and
hypercholesterolemia, while telmisartan and pitavastatin calcium can be used as a potential
drug combination.

Objective:
The aim of this paper is to study the intestinal absorption and absorption interaction
of telmisartan and pitavastatin calcium.

Methods:
An HPLC method was developed and validated to determine telmisartan and
pitavastatin calcium in intestinal perfusate simultaneously. The in situ single-pass
perfusion in rats was utilized to investigate the effects of concentrations, intestinal segment
(duodenum, jejunum, ileum and colon) and co-administrated drugs on absorption.

Results:
The effective permeability coefficient and the absorption rate constant of telmisartan
were higher in the duodenum as compared to other intestinal segments. However, the
intestinal absorption of pitavastatin calcium was not segmental dependent. The effective
permeability coefficient and absorption rate constant have no significant difference among
three concentrations of telmisartan, pitavastatin calcium individually and their combination.

Conclusion:
The results showed that telmisartan and pitavastatin calcium were transported
passively, and telmisartan and pitavastatin calcium could be absorbed well in all intestinal
segments. The intestinal absorption parameters revealed the absence of any intestinal absorption
interaction when co-administered.

Lay Summary:
Co-administration of telmisartan and pitavastatin calcium can provide a
potential therapeutic strategy for the treatment of concurrent hypertension and hypercholesterolemia.
We are investigating the intestinal interaction of these two drugs in rats using
the developed HPLC method and in situ single-pass perfusion technology. We will calculate
some parameters after administrating two types of drugs either separately or together,
which help reflect changes regarding intestinal absorption and penetration. Compared with
telmisartan and pitavastatin calcium administrated separately, if parameters significantly
change after co-administration, it proves the existence of the intestinal interactions. Moreover,
the results might contribute to clinic drug monitoring.