bluuebunny/crossref_metadata_2025_split huggingface dataset:
The high expression of MTH1 and NUDT5 predict a poor survival and are associated with malignancy of esophageal squamous cell carcinoma
Authors: Wang Jing-Jing , Liu Teng-Hui , Li Jin , Li Dan-Ni , Tian Xin-Yuan , Ouyang Qiu-Geng , Cai Jian-Ping 
Published: May 2020

BackgroundMTH1 and NUDT5 effectively degrade nucleotides containing 8-oxoguanine. MTH1 and NUDT5 have been linked to the malignancy of multiple cancers. However, their functions in tumor growth and metastasis in esophageal squamous carcinoma (ESCC) remain obscure. Our present study aims to explore their prognostic value in ESCC and investigate their function in MTH1 or NUDT5-knockout tumor cells.MethodsMTH1 and NUDT5 protein expression in ESCC adjacent normal tissues and tumor tissues was examined by immunohistochemistry staining. Kaplan–Meier curves were used to assess the association between their expression and overall survival (OS) in ESCC patients. Univariate and Multivariate Cox regression analyses were generated to determine the correlation between these protein expression and OS of ESCC patients. Protein expression in ESCC cell lines were measured by Western blotting. To explore the potential effects of the MTH1 and NUDT5 protein in ESCC, cell models with MTH1 or NUDT5 depletion were established. CCK-8, cell cycle, Western blotting, migration and invasion assays were performed.ResultsOur present study demonstrated that the levels of MTH1 and NUDT5 were upregulated in ESCC cell lines and ESCC tissues, the expression of MTH1 and NUDT5 in ESCC tissues was significantly higher than in adjacent non-tumorous, and higher levels of MTH1 and NUDT5 predicted a worse prognosis in patients with ESCC. MTH1 and NUDT5 are novel biomarkers of the progression of ESCC and a poor prognosis. We also found for the first time that the high expression of NUDT5 independently predicted lower OS in patients with ESCC (hazard ratio (HR) 1.751; 95% confidence interval (CI) [1.056–2.903];p= 0.030). In addition, the depletion of MTH1 and NUDT5 strongly suppressed the proliferation of ESCC cells and significantly delayed the G1 phase of the cell cycle. Furthermore, we found that MTH1 and NUDT5 silencing inhibited epithelial–mesenchymal transition mainly by the MAPK/MEK/ERK dependent pathway, which in turn significantly decreased the cell migration and invasion of ESCC cells. Our results suggested that the overexpression of MTH1 and NUDT5 is probably involved in the tumor development and poor prognosis of ESCC.
Genome-wide identification and characterization of the fibrillin gene family in Triticum aestivum
Authors: Jiang Yaoyao , Hu Haichao , Ma Yuhua , Zhou Junliang 
Published: May 2020

Background
The fibrillin (FBN) gene family is highly conserved and widely distributed in the photosynthetic organs of plants. Members of this gene family are involved in the growth and development of plants and their response to biotic and abiotic stresses. Wheat (Triticum aestivum), an important food crop, has a complex genetic background and little progress has occurred in the understanding of its molecular mechanisms.

Methods
In this study, we identified 26 FBN genes in the whole genome of T. aestivum through bioinformatic tools and biotechnological means. These genes were divided into 11 subgroups and were distributed on 11 chromosomes of T. aestivum. Interestingly, most of the TaFBN genes were located on the chromosomes 2A, 2B and 2D. The gene structure of each subgroup of gene family members and the position and number of motifs were highly similar.

Results
The evolutionary analysis results indicated that the affinities of FBNs in monocots were closer together. The tissue-specific analysis revealed that TaFBN genes were expressed in different tissues and developmental stages. In addition, some TaFBNs were involved in one or more biotic and abiotic stress responses. These results provide a basis for further study of the biological function of FBNs.
Automation of Monte Carlo‐based treatment plan verification for proton therapy
Authors: Kaluarachchi Maduka , Moskvin Vadim , Pirlepesov Fakhriddin , Wilson Lydia J. , Xie Fang , Faught Austin M. 
Published: May 2020

AbstractPurposeIndependent calculations of proton therapy plans are an important quality control procedure in treatment planning. When using custom Monte Carlo (MC) models of the beamline, deploying the calculations can be laborious, time consuming, and require in‐depth knowledge of the computational environment. We developed an automated framework to remove these barriers and integrate our MC model into the clinical workflow.Materials and MethodsThe Eclipse Scripting Application Programming Interface was used to initiate the automation process. A series of MATLAB scripts were then used for preprocessing of input data and postprocessing of results. Additional scripts were used to monitor the calculation process and appropriately deploy calculations to an institutional high‐performance computing facility. The automated framework and beamline models were validated against 160 patient specific QA measurements from an ionization chamber array and using a ±3%/3 mm gamma criteria.ResultsThe automation reduced the human‐hours required to initiate and run a calculation to 1–2 min without leaving the treatment planning system environment. Validation comparisons had an average passing rate of 99.4% and were performed at depths ranging from 1 to 15 cm.ConclusionAn automated framework for running MC calculations was developed which enables the calculation of dose and linear energy transfer within a clinically relevant workflow and timeline. The models and framework were validated against patient specific QA measurements and exhibited excellent agreement. Before this implementation, execution was prohibitively complex for an untrained individual and its use restricted to a research environment.
Stress‐matrix‐based formation transformation control under mixed control variables
Authors: Pan Yunlong , Yang Qingkai , Zhou Bo , Fang Hao 
Published: May 2020

AbstractIn this article, we consider the distributed planar formation control problem, in which only three agents have access to the desired geometry information specified by different sensing control variables, including the distance and bearing (angle). With the aim to achieve flexible transformation motions, the stress matrix is invoked to activate the affine formation control technique, rendering the system more freedom in the sense that the whole formation shape can be altered via controlling a small number of agents. By integrating the distance and bearing (angle) measurements, a new control algorithm is proposed such that the formation can be smoothly changed according to the prescribed control variables imposed on the informed agents. Moreover, the orientation of the whole formation is also controllable while forming the desired geometry shape. Finally, simulation results are presented to validate the effectiveness of the proposed control scheme.
Zinc Complexes of β‐Ketoiminato Ligands as Efficient Catalysts for the Synthesis of α‐Amino Nitriles via Strecker Reaction
Authors: Das Suman , Kumar Ravi , Devadkar Ajitrao , Panda Tarun K. 
Published: May 2020

AbstractWe report the synthesis of α‐aminonitriles by one‐pot coupling reaction of aldehyde, amines and trimethylsilyl cyanide (TMSCN) using β‐ketoiminato zinc complexes as a pre‐catalyst in very good yield under mild reaction condition. Homoleptic zinc complex [{κ2‐(2,4,6‐Me3C6H2NC(Me)=CHC(Me)=O)}2Zn] (1 a) was synthesized by the treatment of protic ligand [(2,4,6‐Me3C6H2NHC(Me)=CHC(Me)=O)] (L1H) with potassium hydride and anhydrous zinc diiodide in 2 : 2 : 1 molar ratio in THF. Analogous reactions using [(2,6‐iPr2C6H3NHC(Me)=CHC(Me)=O)] (L2H) and [(Ph2CHNHC(Me)=CHC(Me)=O)] (L3H) as protic ligands, dinuclear zinc complexes [{κ3‐(2,6‐iPr2C6H3NC(Me)=CHC(Me)=O)}ZnI]2 (1 b) and [Zn(Ph2CHNHC−(Me)=CHC(Me)=O)ZnI2] (1 c) were obtained in good yield. Molecular structures of ligands L1H, L3H, and zinc complexes 1 a, 1 b, and 1 c were established by single‐crystal x‐ray diffraction analysis. Dinuclear zinc complexes 1 b, and 1 c exhibited high transformation, greater selectivity and broad substrate scope for the synthesis of α‐aminonitrile under mild condition. A most plausible mechanism for synthesis α‐aminonitrile is proposed based on several controlled reactions.
Macaques in China: Evolutionary dispersion and subsequent development
Authors: Li Baoguo , He Gang , Guo Songtao , Hou Rong , Huang Kang , Zhang Pei , Zhang He , Pan Ruliang , Chapman Colin A. 
Published: May 2020

AbstractDepicting a taxonomic group's evolutionary trajectory as a function of changes in the geographical landscape and its historical distribution is critical for constructing informed conservation strategies. Based on fossil sites from the Pliocene to the Holocene, and historical records since 1175 AD, we established macaques’ dispersal pathways into and through China. These routes include internal pathways starting from the southeast corner of the Qinghai‐Tibet Plateau and Mts. Hengduan in western China, and the routes through the estuaries of the three major rivers (Yangtze, Yellow, and Pearl). Our results indicate that macaques used the three rivers and avoided the higher elevation of the plateaus to promote their radiation. They occupied the whole mainland and islands in the Pleistocene and experienced shrunken distribution in the Holocene due to climate changes and human‐induced activities. A prominent China‐wide reduction occurred between 1817 and 1917; and a remarkable retraction from central China happened between 1918 and 2018 following further eco‐social development and human expansion in central China, particularly since the second half of the last century. Starting in 1175 there was a restriction of range to higher altitudes, so that macaques have contracted their range to the west, and the Qinghai‐Tibet Plateau and Mts. Hengduan have become an important sanctuary. We predict that if the current climate and human‐induced changes are not reversed by decisive conservation actions, macaques in east and central China will likely be extinct in the near future.
Heiße Luft oder cooler Duft? Die Trends der letzten 20 Jahre in der Riechstoffchemie
Authors: Armanino Nicolas , Charpentier Julie , Flachsmann Felix , Goeke Andreas , Liniger Marc , Kraft Philip 
Published: May 2020

AbstractDieser Aufsatz ist die Fortsetzung unseres Berichtes über die neuesten Trends der Riechstoffchemie aus dem Jahr 2000 und fasst die Entwicklungen der letzten 20 Jahren zusammen. Dem selben Duftspektrum folgend, werden besonders richtungsweisende Captives (patentgeschützte Riechstoffe, die nicht frei verkäuflich sind) vorgestellt, und die Einteilung in die Geruchsfamilien “fruchtig”, “grün”, “marin”, “blumig”, “würzig”, “holzig”, “Ambra” und “Moschus” wird auch in dieser Übersicht beibehalten. Das Design von Riechstoffen, ihre chemische Synthese und ihre Verwendung in der modernen Parfümerie werden anhand von prominenten Beispielen illustriert. Unter anderem werden neue fruchtige Riechstoffe vorgestellt, die vor allem der Kopfnote von Parfüms eine besondere Signatur verleihen, aber auch durch Anwendung von Präkursor‐Technologien in der Basisnote einen olfaktorischen Beitrag leisten können. Bei den Grünnoten liegt der Schwerpunkt auf grünen Blättern und Birnen. Neue Benzodioxepine und Benzodioxole haben die marine Familie modernisiert und machten eine Überarbeitung der Olfaktophor‐Modelle notwendig. Bedeutende regulatorische Einschränkungen des Gebrauchs von Lilial und Lyral bereicherten die Parfümindustrie im floralen Bereich mit einer großen Fülle von neuen Maiglöckchen‐Riechstoffen. Darüber hinaus wurde intensiv nach neuen Rosen‐Riechstoffen geforscht, wobei ein besonderes Augenmerk auf Rosenketonen lag. Die Biotechnologie gewann signifikant an Bedeutung, wie mit Clearwood und Ambrofix belegt wird. In der holzigen Duftfamilie wurde das riechende Prinzip des Vetiveröls aufgeklärt. Eine vierte und sogar fünfte Verbindungsklasse von Moschus‐Riechstoffen wurde entdeckt, von denen einige Derivate besondere wirtschaftliche Bedeutung erlangten. All diese Aktivitäten eröffneten neue, zukunftsweisende Perspektiven und Forschungsrichtungen in der Chemie der Riechstoffe.
CuPd Nanoparticles as a Robust Catalyst for Electrochemical Allylic Alkylation
Authors: Yin Zhouyang , Pang Huan , Guo Xuefeng , Lin Honghong , Muzzio Michelle , Shen Mengqi , Wei Kecheng , Yu Chao , Williard Paul , Sun Shouheng 
Published: May 2020

AbstractAn efficient CuPd nanoparticle (NP) catalyst (3 nm CuPd NPs deposited on carbon support) is designed for catalyzing electrochemical allylic alkylation in water/isopropanol (1:1 v/v) and 0.2 m KHCO3 solution at room temperature. The Pd catalysis was Pd/Cu composition‐dependent, and CuPd NPs with a Pd/Cu ratio close to one are the most efficient catalyst for the selective cross‐coupling of alkyl halides and allylic halides to form C−C hydrocarbons with product yields reaching up to 99 %. This NP‐catalyzed electrochemical allylic alkylation expands the synthetic scope of cross‐coupling reactions and can be further extended to other organic reaction systems for developing green chemistry electrosynthesis methods.
Values, gender and attitudes towards environmental policy: A study of future managers
Authors: Bhattacharyya Asit , Rahman Mohammed Lutfur 
Published: May 2020

AbstractThis study explores if the value priorities and their impact on future managers' attitudes towards environmental responsibilities vary with gender. While relevant prior studies mostly focus on gender‐based variations of individuals' personal values in developed economies, we concentrate on both personal values and pro‐environmental attitudes in an emerging economy. This study is built on MBA students (a proxy for future managers) in India since India is characterized as a male‐dominated society and a producer of larger number of MBA graduates. Overall, our results show that personal values and attitude towards environmental responsibilities do not vary significantly with gender. Only two values (among the 21 values) and one value type (out of 10 values) get significantly higher ranking from females compared with males. Further, although ‘universalism’ and ‘benevolence’ are found to have a statistically significant impact on respondents' attitude towards environmental responsibility, the latter is invariant to the respondents' gender. Our findings may indicate India's transformation from a male‐dominated society towards a more gender‐balanced society. These findings can be used to operationalize a pro‐environmental recruitment policy and to formulate strategies to improve female participation in MBA cohorts of business schools.
Controllable Synthesis of Fe‐Doped NiCo2O4 Nanobelts as Superior Catalysts for Oxygen Evolution Reaction
Authors: Wei Pengkun , Yang Yang , Kang Hongzhi , Hao Zewei , Guo Donggang , Liu Lu 
Published: May 2020

AbstractAs one of the promising clean and renewable technologies, water splitting has been a hot topic, especially the half‐reaction of oxygen evolution reaction (OER) due to its sluggish and complex kinetics. Hence, Fe‐doped NiCo2O4 nanobelts were designed and prepared as catalysts toward OER. By increasing the Fe amount, the catalytic performances of the as‐synthesized products went up and then decreased. Profiting from the synergistic effect between Fe atom and NiCo2O4, all the Fe‐NiCo2O4 catalysts exhibited superior catalytic activities to the corresponding NiCo2O4. In addition, the characteristic nanobelt architecture facilitates the conduction of electrons and the exposure of active sites. With the optimal Fe content, the 9.1 % Fe‐NiCo2O4 yielded the smallest overpotential and Tafel slope among the catalysts, distinctly lower than that of RuO2.
Water‐Soluble Rhenium Clusters with Triazoles: The Effect of Chemical Structure on Cellular Internalization and the DNA Binding of the Complexes
Authors: Konovalov Dmitry I. , Ivanov Anton A. , Frolova Tatiana S. , Eltsov Ilia V. , Gayfulin Yakov M. , Plunkett Louis , Bazzar Masoomeh , Adawi Ali M. , Bouillard Jean‐Sebastien G. , Baiborodin Sergey I. , Sinitsyna Olga I. , Kuratieva Natalia V. , Yanshole Vadim V. , Efremova Olga A. , Shestopalov Michael A. 
Published: May 2020

AbstractHere we explore the effect of the nature of organic ligands in rhenium cluster complexes [Re6Q8L6]4− (where Q=S or Se, and L=benzotriazole, 1,2,3‐triazole or 1,2,4‐triazole) on the biological properties of the complexes, in particular on the cellular toxicity, cellular internalization and localization. Specifically, the study describes the synthesis and detailed characterization of the structure, luminescence and electrochemical properties of the four new Re6 clusters with 1,2,3‐ and 1,2,4‐triazoles. Biological assays of these complexes are also discussed in addition to those with benzotriazole using cervical cancer (HeLa) and immortalized human fibroblasts (CRL‐4025) as model cell lines. Our study demonstrates that the presence of hydrophobic and π‐bonding rich units such as the benzene ring in benzotriazole significantly enhances cellular internalization of rhenium clusters. These ligands facilitate binding of the clusters to DNA, which results in increased cytotoxicity of the complexes.
Diazaphospholene and Diazaarsolene Derived Homogeneous Catalysis
Authors: Ould Darren M. C. , Melen Rebecca L. 
Published: May 2020

AbstractThe past 20 years has seen significant advances in main group chemistry and their use in catalysis. This Minireview showcases the recent emergence of phosphorus and arsenic containing heterocycles as catalysts. With that, we discuss how the Group 15 compounds diazaphospholenes, diazaarsolenes, and their cationic counterparts have proven to be highly effective catalysts for a wide range of reduction transformations. This Minireview highlights how the initial discovery by Gudat of the hydridic nature of the P−H bond in these systems led to these compounds being used as catalysts and discusses the wide range of examples currently present in the literature.
A Cornucopia of Iridium Nitrogen Compounds Produced from Laser‐Ablated Iridium Atoms and Dinitrogen
Authors: Stüker Tony , Beckers Helmut , Riedel Sebastian 
Published: May 2020

AbstractInvited for the cover of this issue is the group of Sebastian Riedel at Freie Universität Berlin. The image depicts an iridium rainbow reacting with dinitrogen to form iridium–nitrogen compounds. Read the full text of the article at 10.1002/chem.201905514.
Innovative Syntheses of Cyano(fluoro)borates: Catalytic Cyanation, Electrochemical and Electrophilic Fluorination
Authors: Drisch Michael , Bischoff Lisa A. , Sprenger Jan A. P. , Hennig Philipp T. , Wirthensohn Raphael , Landmann Johannes , Konieczka Szymon Z. , Hailmann Michael , Ignat'ev Nikolai V. , Finze Maik 
Published: May 2020

AbstractDifferent types of high‐yield, easily scalable syntheses for cyano(fluoro)borates Kt[BFn(CN)4−n] (n=0–2) (Kt=cation), which are versatile building blocks for materials applications and chemical synthesis, have been developed. Tetrafluoroborates react with trimethylsilyl cyanide in the presence of metal‐free Brønsted or Lewis acid catalysts under unprecedentedly mild conditions to give tricyanofluoroborates or tetracyanoborates. Analogously, pentafluoroethyltrifluoroborates are converted into pentafluoroethyltricyanoborates. Boron trifluoride etherate, alkali metal salts, and trimethylsilyl cyanide selectively yield dicyanodifluoroborates or tricyanofluoroborates. Fluorination of cyanohydridoborates is the third reaction type that includes direct fluorination with, for example, elemental fluorine, stepwise halogenation/fluorination reactions, and electrochemical fluorination (ECF) according to the Simons process. In addition, fluorination of [BH(CN)2{OC(O)Et}]− to result in [BF(CN)2{OC(O)Et}]− is described.
Can we restore the colour of long‐term discoloured resin composites by noninvasive methods?
Authors: Atalayin Ozkaya Cigdem , Yasa Bilal , Demirhan Ali Osman , Turkun Lezize Sebnem 
Published: May 2020

AbstractThe aim of this study is to investigate the effect of toothbrushing and paste repolishing on the colour restitution of long‐term coffee discoloured prefabricated and direct resin composites. One prefabricated (Componeer‐Coltène) and three direct resin composites (Brilliant Ever Glow‐Coltène, Essentia‐GC, Harmonize‐Kerr) were tested. Componeer samples were prepared with and without polishing while the other groups were all polished. After baseline colour‐measurement, the specimens were immersed in coffee for 3‐month and colour‐measurement was repeated, then a simulation of 1‐year of toothbrushing (Toothbrush Simulation ZM‐3.4‐SD Mechatronics) with Pro‐Expert Professional Protection‐Ipana, 3D White Luxe Perfection‐Ipana, and White Ruscello‐GC toothpaste was performed. Colour‐changes (ΔE) after toothbrushing and repolishing with polishing paste (Enamelize, Cosmodent) were calculated. The discolouration occurred after prolonged exposure to a coffee solution was above the clinically acceptable level of ΔE = 2 in all groups, except Componeer polished group. The lowest discoloured group was Componeer polished (ΔE = 1.66 ± 0.32) while the highest was Essentia group (ΔE = 4.30 ± 0.48). The samples toothbrushed with White Ruscello exhibited the greatest colour restitution (ΔE = 2.06 ± 0.75) (P < .05). After paste repolishing, slight colour restitution was observed among all the groups, but the differences between them remained the same as after the toothbrushing procedure. Prolonged exposure to coffee solution affects the colour of the resin composites and noninvasive methods can provide colour restitution below the critical value for visual perception (ΔE = 3.3). Noninvasive procedures such as toothbrushing with a whitening toothpaste or repolishing with a polishing paste may ensure the colour restitution of direct resin composite restorations until a clinically acceptable level.
Special Issue on Context‐Aware Computing: Theory and Applications
Authors: Vinh Phan Cong 
Published: May 2020

SummaryThe special issue with the title of “Context‐Aware Computing: Theory and Applications” edited by Prof. Phan Cong Vinh is presented to researchers in the field of context‐aware computing. This issue does not introduce a methodology for formal specification and reasoning in context‐aware computing. It presents theoretical bases in context‐aware computing and connects basic reasoning problems to other fundamental issues in context‐aware computing. In short, the special issue tries to get answer to the following question: “How far can it go in context‐aware computing specification and reasoning by representing context‐aware computing with formal notions in process algebras sense and reasoning with formal logics?”.