bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can repeated soil amendment with biogas digestates increase soil suppressiveness toward non-specific soil-borne pathogens in agricultural lands?
Authors: Manici L. M. , Caputo F. , Cappelli G. A. , Ceotto E. 
Published: December 2020

AbstractSoil suppressiveness which is the natural ability of soil to support optimal plant growth and health is the resultant of multiple soil microbial components; which implies many difficulties when estimating this soil condition. Microbial benefits for plant health from repeated digestate applications were assessed in three experimental sites surrounding anaerobic biogas plants in an intensively cultivated area of northern Italy. A 2-yr trial was performed in 2017 and 2018 by performing an in-pot plant growth assay, using soil samples taken from two fields for each experimental site, of which one had been repeatedly amended with anaerobic biogas digestate and the other had not. These fields were similar in management and crop sequences (maize was the recurrent crop) for the last 10 yr. Plant growth response in the bioassay was expressed as plant biomass production, root colonization frequency by soil-borne fungi were estimated to evaluate the impact of soil-borne pathogens on plant growth, abundance of Pseudomonas and actinomycetes populations in rhizosphere were estimated as beneficial soil microbial indicators. Repeated soil amendment with digestate increased significantly soil capacity to support plant biomass production as compared to unamended control in both the years. Findings supported evidence that this increase was principally attributable to a higher natural ability of digestate-amended soils to reduce root infection by saprophytic soil-borne pathogens whose inoculum was increased by the recurrent maize cultivation. Pseudomonas and actinomycetes were always more abundant in digestate-amended soils suggesting that both these large bacterial groups were involved in the increase of their natural capacity to control soil-borne pathogens (soil suppressiveness).
Herbicide programs for control of waterhemp (Amaranthus tuberculatus) resistant to three distinct herbicide sites of action in corn
Authors: Willemse Christian , Soltani Nader , Benoit Lauren , Hooker David C. , Jhala Amit J. , Robinson Darren E. , Sikkema Peter 
Published: December 2020

AbstractControl of waterhemp is becoming more difficult in Ontario because biotypes have evolved resistance to four herbicide sites of action (SOA), including groups 2, 5, 9, and 14. The objective of this study was to compare PRE, POST, and PRE followed by (fb) POST herbicide programs for their effect on control, density, and biomass of multiple-herbicide–resistant (MHR) waterhemp as well as corn injury and grain yield. Two separate field studies, each consisting of five field trials, were conducted over a 2-yr period (2018 and 2019) in fields where corn was grown in Ontario, Canada. The first experiment evaluated MHR waterhemp control with an inhibitor of 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) applied PRE, PRE fb glufosinate applied POST, and glufosinate applied POST. The second experiment evaluated MHR waterhemp control with a non-HPPD inhibitor applied PRE, then PRE fb a POST application of atrazine + mesotrione, and then atrazine + mesotrione applied POST. Atrazine + isoxaflutole caused 3% to 5% corn injury at environment 1 (E1); no corn injury was observed with PRE and POST herbicide programs at environments E2, E3, E4, and E5. In general, atrazine/bicyclopyrone/mesotrione/S-metolachlor and dimethenamid-P/saflufenacil applied PRE controlled MHR waterhemp ≥95% 12 wk after POST application (WAA). A POST application of glufosinate following atrazine + tolpyralate PRE, and a POST application of atrazine + mesotrione following atrazine/dicamba or atrazine/S-metolachlor PRE, improved control at 4, 8, and 12 WAA in most environments. In general, PRE fb POST applications resulted in better control of MHR waterhemp throughout the growing season than single PRE and POST applications (P < 0.05). We conclude that herbicide programs based on multiple effective SOAs may offer effective control of MHR waterhemp where field corn is grown. It is advisable that when choosing an herbicide application program that excellent control of MHR waterhemp should be the goal given its high fecundity and competitive ability.
Growth of Collisional Orogens From Small and Cold to Large and Hot—Inferences From Geodynamic Models
Authors: Wolf Sebastian G. , Huismans Ritske S. , Muñoz Josep‐Anton , Curry Magdalena Ellis , van der Beek Peter 
Published: December 2020

AbstractIt is well documented that the interplay between crustal thickening and surface processes determines growth of continent‐continent collision orogens from small and cold to large and hot. Additionally, studies have demonstrated that the structural style of a mountain belt is strongly influenced by inherited (extensional) structures, the pattern of erosion and deposition, as well as the distribution of shallow detachment horizons. However, the factors controlling distribution of shortening and variable structural style as a function of convergence and surface process efficiency remain less explored. We use a 2D upper‐mantle scale plane‐strain thermo‐mechanical model (FANTOM) coupled to a planform, mass conserving surface‐process model (Fastscape), to investigate the long‐term evolution of mountain belts and the influence of lithospheric pull, extensional inheritance, surface processes efficiency, and decoupling between thin‐and thick‐skinned tectonics. We establish an evolutionary shortening distribution for orogenic growth from a mono‐vergent wedge to an orogenic plateau, and find that internal crustal loading is the main factor controlling the large scale evolution, while lithospheric pull modulates the plate driving force for orogenesis. Limited foreland‐basin filling and minor exhumation of the orogen core are characteristic for low surface‐process efficiency, while thick foreland‐basin fill, and profound exhumation of the orogen core are characteristic for high surface‐process efficiency. Utilizing a force balance analysis, we show how inherited structures, surface processes, and decoupling between thin‐and thick‐skinned deformation influence structural style during orogenic growth. Finally, we present a comparison of our generic modeling results with natural systems, with a particular focus on the Pyrenees, Alps, and Himalaya‐Tibet.
Effects of classical PKC activation on hippocampal neurogenesis and cognitive performance: mechanism of action
Authors: Domínguez-García Samuel , Gómez-Oliva Ricardo , Geribaldi-Doldán Noelia , Hierro-Bujalance Carmen , Sendra Marta , Ruiz Félix A. , Carrascal Livia , Macías-Sánchez Antonio J. , Verástegui Cristina , Hernández-Galán Rosario , García-Alloza Mónica , Nunez-Abades Pedro , Castro Carmen 
Published: December 2020

AbstractHippocampal neurogenesis has widely been linked to memory and learning performance. New neurons generated from neural stem cells (NSC) within the dentate gyrus of the hippocampus (DG) integrate in hippocampal circuitry participating in memory tasks. Several neurological and neuropsychiatric disorders show cognitive impairment together with a reduction in DG neurogenesis. Growth factors secreted within the DG promote neurogenesis. Protein kinases of the protein kinase C (PKC) family facilitate the release of several of these growth factors, highlighting the role of PKC isozymes as key target molecules for the development of drugs that induce hippocampal neurogenesis. PKC activating diterpenes have been shown to facilitate NSC proliferation in neurogenic niches when injected intracerebroventricularly. We show in here that long-term administration of diterpene ER272 promotes neurogenesis in the subventricular zone and in the DG of mice, affecting neuroblasts differentiation and neuronal maturation. A concomitant improvement in learning and spatial memory tasks performance can be observed. Insights into the mechanism of action reveal that this compound facilitates classical PKCα activation and promotes transforming growth factor alpha (TGFα) and, to a lesser extent, neuregulin release. Our results highlight the role of this molecule in the development of pharmacological drugs to treat neurological and neuropsychiatric disorders associated with memory loss and a deficient neurogenesis.
Cigarette smoke-induced LKB1/AMPK pathway deficiency reduces EGFR TKI sensitivity in NSCLC
Authors: Cheng Fang-Ju , Chen Chia-Hung , Tsai Wen-Chen , Wang Bo-Wei , Yu Meng-Chieh , Hsia Te-Chun , Wei Ya-Ling , Hsiao Yu-Chun , Hu Dai-Wei , Ho Chien-Yi , Li Tzong-Shiun , Wu Chun-Yi , Chou Wen-Yu , Yu Yung-Luen , Tang Chih-Hsin , Chen Chih-Yi , Chen Chuan-Mu , Hsu Jennifer L. , Chen Hsiao-Fan , Chen Yeh , Tu Chih-Yen , Hung Mien-Chie , Huang Wei-Chien 
Published: December 2020

AbstractSmoker patients with non-small cell lung cancer (NSCLC) have poorer prognosis and survival than those without smoking history. However, the mechanisms underlying the low response rate of those patients to EGFR tyrosine kinase inhibitors (TKIs) are not well understood. Here we report that exposure to cigarette smoke extract enhances glycolysis and attenuates AMP-activated protein kinase (AMPK)-dependent inhibition of mTOR; this in turn reduces the sensitivity of NSCLC cells with wild-type EGFR (EGFRWT) to EGFR TKI by repressing expression of liver kinase B1 (LKB1), a master kinase of the AMPK subfamily, via CpG island methylation. In addition, LKB1 expression is correlated positively with sensitivity to TKI in patients with NSCLC. Moreover, combined treatment of EGFR TKI with AMPK activators synergistically increases EGFR TKI sensitivity. Collectively, the current study suggests that LKB1 may serve as a marker to predict EGFR TKI sensitivity in smokers with NSCLC carrying EGFRWTand that the combination of EGFR TKI and AMPK activator may be a potentially effective therapeutic strategy against NSCLC with EGFRWT.
Identification of crystal symmetry from noisy diffraction patterns by a shape analysis and deep learning
Authors: Tiong Leslie Ching Ow , Kim Jeongrae , Han Sang Soo , Kim Donghun 
Published: December 2020

AbstractThe robust and automated determination of crystal symmetry is of utmost importance in material characterization and analysis. Recent studies have shown that deep learning (DL) methods can effectively reveal the correlations between X-ray or electron-beam diffraction patterns and crystal symmetry. Despite their promise, most of these studies have been limited to identifying relatively few classes into which a target material may be grouped. On the other hand, the DL-based identification of crystal symmetry suffers from a drastic drop in accuracy for problems involving classification into tens or hundreds of symmetry classes (e.g., up to 230 space groups), severely limiting its practical usage. Here, we demonstrate that a combined approach of shaping diffraction patterns and implementing them in a multistream DenseNet (MSDN) substantially improves the accuracy of classification. Even with an imbalanced dataset of 108,658 individual crystals sampled from 72 space groups, our model achieves 80.12 ± 0.09% space group classification accuracy, outperforming conventional benchmark models by 17–27 percentage points (%p). The enhancement can be largely attributed to the pattern shaping strategy, through which the subtle changes in patterns between symmetrically close crystal systems (e.g., monoclinic vs. orthorhombic or trigonal vs. hexagonal) are well differentiated. We additionally find that the MSDN architecture is advantageous for capturing patterns in a richer but less redundant manner relative to conventional convolutional neural networks. The proposed protocols in regard to both input descriptor processing and DL architecture enable accurate space group classification and thus improve the practical usage of the DL approach in crystal symmetry identification.
Cerina: systematic circRNA functional annotation based on integrative analysis of ceRNA interactions
Authors: Cardenas Jacob , Balaji Uthra , Gu Jinghua 
Published: December 2020

AbstractCircular RNAs, a family of covalently circularized RNAs with tissue-specific expression, were recently demonstrated to play important roles in mammalian biology. Regardless of extensive research to predict, quantify, and annotate circRNAs, our understanding of their functions is still in its infancy. In this study, we developed a novel computational tool: Competing Endogenous RNA for INtegrative Annotations (Cerina), to predict biological functions of circRNAs based on the competing endogenous RNA model. Pareto Frontier Analysis was employed to integrate ENCODE mRNA/miRNA data with predicted microRNA response elements to prioritize tissue-specific ceRNA interactions. Using data from several circRNA-disease databases, we demonstrated that Cerina significantly improved the functional relevance of the prioritized ceRNA interactions by several folds, in terms of precision and recall. Proof-of-concept studies on human cancers and cardiovascular diseases further showcased the efficacy of Cerina on predicting potential circRNA functions in human diseases.
Flavonoids and alkaloids from the rhizomes of Zephyranthes ajax Hort. and their cytotoxicity
Authors: Nguyen Khan Viet , Ho Duc Viet , Le Nhan Trong , Van Phan Kiem , Heinämäki Jyrki , Raal Ain , Nguyen Hoai Thi 
Published: December 2020

AbstractA new flavanol derivative, (2R,3R)-3-acetoxy-7-hydroxy-3′,4′-methylenedioxyflavan (1), was co-isolated from the rhizomes of Zephyranthes ajax Hort. with the following seven known compounds: 7-hydroxyflavan (2), 7,4′-dihydroxyflavan (3), 7,4′-dihydroxy-8-methylflavan (4), 7,3′-dihydroxy-4′-methoxyflavan (5), 5,4′-dihydroxy-7-methoxy-6-methylflavan (6), 7-hydroxy-3′,4′-methylenedioxyflavanone (7) and haemanthamine (8). Their structures were elucidated by combining 1D-/2D-NMR, CD, UV and HRESIMS data, and comparisons with reported data in literature were made. Among these known compounds, 2, 3, 4, 6 and 7 were isolated from the genus Zephyranthes for the first time. In addition, the cytotoxicity assay indicated that compound 8 has potent cytotoxic activity against human hepatocellular carcinoma (the HepG2 cell line), human lung carcinoma (the SK-LU-1 cell line), human carcinoma in the mouth (the KB cell line), human colon carcinoma (the SW480 cell line) and human stomach gastric adenocarcinoma (the AGS cell line), with IC50 values ranging from 4.4 to 11.3 µM. This is the first study reporting the cytotoxicity of compound 8 against the SK-LU-1 cancer cell lines.
New discovery of two seismite horizons challenges the Ries–Steinheim double-impact theory
Authors: Buchner Elmar , Sach Volker J. , Schmieder Martin 
Published: December 2020

AbstractThe Nördlinger Ries and the Steinheim Basin are widely perceived as a Middle Miocene impact crater doublet. We discovered two independent earthquake-produced seismite horizons in North Alpine Foreland Basin deposits potentially related to both impacts. The older seismite horizon, demonstrated to be associated with the Ries impact, is overlain by distal impact ejecta in situ, forming a unique continental seismite-ejecta couplet within a distance of up to 180 km from the crater. The younger seismite unit, also produced by a major palaeo-earthquake, comprises clastic dikes that cut through the Ries seismite-ejecta couplet. The clastic dikes may have formed in response to the Steinheim impact, some kyr after the Ries impact, in line with paleontologic results that indicate a time gap of about 0.5 Myr between the Ries and Steinheim events. This interpretation suggests the Ries and Steinheim impacts represent two temporally separate events in Southern Germany that, thus, witnessed a double disaster in the Middle Miocene. The magnitude–distance relationship of seismite formation during large earthquakes suggests the seismic and destructive potential of impact-induced earthquakes may be underestimated.
Numerical simulation of tropical cyclone generated waves in South China Sea during winter monsoon surge
Authors: Qi Peng , Wang Aimei 
Published: December 2020

AbstractThe South China Sea (SCS) is a highly semi-enclosed marginal sea located in the East Asian monsoon region. This paper proposes interesting aspects of the unique feature of the SCS waves in response to tropical cyclone's passage when large-scale winter monsoon winds prevail. We use the wave model WaveWatch III to study the wave characteristics of typhoon Durian (2006) passing over the middle of SCS in early December 2006, and state the new understanding acquired in the aspects of the tropical cyclone generated waves in the SCS during winter monsoon surge. In light of this, the role of the large-scale NE monsoon winds on winter typhoon wave field characteristics in the SCS are highlighted by conducting sensitivity experiments with and without the NE monsoon winds. The NE monsoon winds weakly affect the SWH field near the typhoon track and strongly away from the track, especially in the deep water area of the northern SCS where the NE monsoon winds produce high waves. Comparisons between the two experiments show the effect of the NE monsoon winds on the directional wave spectra in the SCS, suggesting that the monsoon-generated swells do not decay and remain throughout the typhoon period.
Antimicrobial peptides in patients with anorexia nervosa: comparison with healthy controls and the impact of weight gain
Authors: Bendix Marie-Christin , Stephan Michael , Nöhre Mariel , Wünsch-Leiteritz Wally , Schmidt Hagen , Tiegs Gisa , Harder Jürgen , de Zwaan Martina 
Published: December 2020

AbstractClinical observations show that patients with anorexia nervosa (AN) are surprisingly free from infectious diseases. There is evidence from studies in Drosophila melanogaster that starvation leads to an increased expression of antimicrobial peptides (AMPs). AMPs are part of the innate immune system and protect human surfaces from colonization with pathogenic bacteria, viruses and fungi. We compared the expression of AMPs between patients with AN and healthy controls (HC) and investigated the influence of weight gain. Using a standardized skin rinsing method, quantitative determination of the AMPs psoriasin and RNase 7 was carried out by ELISA. Even though non-significant, effect sizes revealed slightly higher AMP concentrations in HC. After a mean weight gain of 2.0 body mass index points, the concentration of psoriasin on the forehead of patients with AN increased significantly. We could not confirm our hypotheses of higher AMP concentrations in patients with AN that decrease after weight gain. On the contrary, weight gain seems to be associated with increasing AMP concentrations.
Ultrathin polymeric films for interfacial passivation in wide band-gap perovskite solar cells
Authors: Ferdowsi Parnian , Ochoa-Martinez Efrain , Alonso Sandy Sanchez , Steiner Ullrich , Saliba Michael 
Published: December 2020

AbstractWide band-gap perovskite solar cells have the potential for a relatively high output voltage and resilience in a degradation-inducing environment. Investigating the reasons why high voltages with adequate output power have not been realized yet is an underexplored part in perovskite research although it is of paramount interest for multijunction solar cells. One reason is interfacial carrier recombination that leads to reduced carrier lifetimes and voltage loss. To further improve the Voc of methylammonium lead tri-bromide (MAPbBr3), that has a band-gap of 2.3 eV, interface passivation technique is an important strategy. Here we demonstrate two ultrathin passivation layers consisting of PCBM and PMMA, that can effectively passivate defects at the TiO2/perovskite and perovskite/spiro-OMeTAD interfaces, respectively. In addition, perovskite crystallization was investigated with the established anti-solvent method and the novel flash infrared annealing (FIRA) with and without passivation layers. These modifications significantly suppress interfacial recombination providing a pathway for improved VOC’s from 1.27 to 1.41 V using anti solvent and from 1.12 to 1.36 V using FIRA. Furthermore, we obtained more stable devices through passivation after 140 h where the device retained 70% of the initial performance value.
Relativistic fluid modelling of gamma-ray binaries
Authors: Huber D. , Kissmann R. , Reimer A. , Reimer O. 
Published: December 2020

Context.Gamma-ray binaries are systems that radiate the dominant part of their non-thermal emission in the gamma-ray band. In a wind-driven scenario, these binaries are thought to consist of a pulsar orbiting a massive star, accelerating particles in the shock arising in the wind collision.Aims.We develop a comprehensive numerical model for the non-thermal emission of shock-accelerated particles including the dynamical effects of fluid instabilities and orbital motion. We demonstrate the model on a generic binary system.Methods.The model was built on a dedicated three-dimensional particle transport simulation for the accelerated particles that were dynamically coupled to a simultaneous relativistic hydrodynamic simulation of the wind interaction. In a post-processing step, a leptonic emission model involving synchrotron and inverse-Compton emission was evaluated based on resulting particle distributions and fluid solutions, consistently accounting for relativistic boosting andγγ-absorption in the stellar radiation field. The model was implemented as an extension to the CRONOScode.Results.In the generic binary, the wind interaction leads to the formation of an extended, asymmetric wind-collision region distorted by the effects of orbital motion, mixing, and turbulence. This gives rise to strong shocks terminating the pulsar wind and secondary shocks in the turbulent fluid flow. With our approach it is possible for the first time to consistently account for the dynamical shock structure in particle transport processes, which yields a complex distribution of accelerated particles. The predicted emission extends over a broad energy range, with significant orbital modulation in all bands.
Das Mikrobiom als Drehscheibe für Nebenwirkungen der Protonenpumpenhemmer-Therapie
Authors: Horvath Angela , Stadlbauer Vanessa 
Published: December 2020

ZusammenfassungProtonenpumpenhemmer werden seit etwa 30 Jahren erfolgreich gegen magensäureassoziierte Erkrankungen, wie peptische Ulzera oder Refluxerkrankungen, eingesetzt. Durch ihre kovalente Bindung an die Protonenpumpen in den Parietalzellen des Magens kann die Magensäureproduktion effektiv reduziert und die therapeutische Wirkung der Protonenpumpenhemmer entfaltet werden. Auf diese Weise wird aber auch ein wichtiger Bestandteil der unspezifischen Immunabwehr ausgeschaltet, der den Körper – und vor allem das Darmmikrobiom – vor mit der Nahrung aufgenommenen Pathogenen oder eingeschwemmten Mundkeimen schützt. Daraus ergeben sich Veränderungen des Darmmikrobioms, wie eine Reduktion der Diversität des Mikrobioms oder eine Fehlbesiedelung des Dünndarms, die mit verschiedenen Nebenwirkungen der Protonenpumpen-(Langzeit-)Therapie, wie einem erhöhten Risiko für Clostridium-difficile-Infektionen oder gastrointestinalen Beschwerden, assoziiert sind. Bei Menschen mit Leberzirrhose bspw.
ist die Einwanderung von oralen Bakterien in den Darm mit intestinaler Inflammation und Permeabilität verbunden und kann als Biomarker für das 3-Jahres-Überleben herangezogen werden. Mikrobiomassoziierte Nebenwirkungen sollten daher in den Diskurs über die Risiken von Langzeittherapien mit Protonenpumpenhemmern und dem Abwägen von Alternativen miteinbezogen werden.