bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hamilcar of Barce? Discerning Barcid proto-history and Polybius’ mixellēnes
Authors: Hill Andrew M. 
Published: December 2020

Abstract:Hamilcar and Hannibal Barca embody a colossal father-son military legacy. Yet their family – the so-called ‘Barcid’ dynasty – has a murky history. Modern scholars have presumed that Hamilcar, the first notable historical figure to bear the name Barkas, received it as a ‘nickname’ meaning ‘lightning’. The rationale is that the name derives from the Phoenician word brq and is thus the equivalent to the Greek epithet Keraunos. There is, however, no evidence in our classical sources, to which exclusively we owe our knowledge of events, supporting this. Furthermore, the name Barca was passed on to Hamilcar’s sons, something suggestive of an inherited family surname. This article submits an alternative to the widely endorsed ‘lightning’ theory. This new perspective explores the possibility that the Barcid dynasty had roots in the city of Barce in Cyrenaica and was a relatively new addition to the Carthaginian aristocracy in the third century BC. Using textual evidence from Polybius, Diodorus and others, this fresh take clarifies other aspects of the Barcid dynasty’s tumultuous history, such as their animosity towards the Carthaginian Council of Elders and their departure to Spain in the 220s.
The historian Philip of Pergamon
Authors: Jones Christopher P. 
Published: December 2020

Abstract:This article studies the inscription IG IV2 1.687 (FGrH 95), the only evidence for the historian Philip of Pergamon. The subjects considered include the text itself, the appearance of the stone and the layout in imitation of papyrus, the date as evidenced by the lettering, the use of the Ionic dialect and the references to ‘suffering and continuous mutual slaughter’. Finally, it is proposed that Philip may be ‘the historian Philip’ mentioned in a dialogue of Plutarch.
Ventricular septal defect: diagnosis and treatments in the neonates: a systematic review
Authors: Adan Ahmed , Eleyan Loay , Zaidi Mariam , Ashry Amr , Dhannapuneni Ram , Harky Amer 
Published: December 2020

AbstractBackground:Medical advancements have encouraged minimally invasive surgical repair of congenital heart defects such as ventricular septal defects (VSDs), and the diagnostic process can now be carried out using non-traditional techniques such as pulse oximetry. This, in turn, has improved clinical outcomes with reduced complication rates post-surgery. However, the variations in type of VSDs, age of patient, comorbidities, and access to closure devices may limit the efficacy of surgical advancements.Methods:Articles were identified amongst Scopus, MEDLINE, and PubMed using various relevant search strings using PRISMA guidelines. Of the 115 articles initially extracted, 10 were eventually reviewed after duplicates and irrelevant studies were removed.Results:Of the 24 eligible articles, 10 papers were selected for analysis. Minimally invasive approaches to VSD repair was associated with satisfactory short-term outcomes when compared to open repair. For diagnosis of congenital VSD, whilst recent advances such as pulse oximetry method and genome analysis are more sensitive, the limited availability and access to such investigatory methods must be recognised.Conclusion:Pulse oximetry and fetal echocardiography are established non-invasive diagnostic tools for VSD. The recent advances in minimally invasive treatment options including periventricular approach and transcatheter techniques have improved patient outcomes, yet at the expense of higher residual rates. Careful patient selection for each technique and follow-up should be planned through multidisciplinary team meetings.
Sexual orientation and food insecurity: findings from the New York City Community Health Survey
Authors: Testa Alexander , Jackson Dylan B 
Published: December 2020

AbstractObjective:Food insecurity is a serious public health concern that disproportionately impacts minority groups. However, limited research has assessed food insecurity among sexual minorities. The current study investigates whether individuals identifying as lesbian/gay or bisexual (LGB) sexual orientation were more likely to experience food insecurity relative to heterosexual persons.Design:Data are from the 2017 and 2018 New York City Community Health Survey. Multinomial logistic regression is used to assess the association between sexual orientation and food insecurity.Setting:A sample of adults (18 years and older) who identify as heterosexual, gay/lesbian or bisexual living in New York City in 2017 and 2018.Participants:18 610 non-institutionalised adults.Results:Bisexual individuals have significantly higher rates of both mild (relative risk ratio (RRR) = 1·719, 95 % CI 1·148, 2·573) and moderate-to-severe food insecurity (RRR = 1·851, 95 % CI 1·097, 3·122) relative to heterosexual individuals, net of covariates from demographic, household and socio-economic characteristics. Study findings showed no difference in the likelihood of food insecurity between gay/lesbian individuals and heterosexual individuals.Conclusion:Results illustrate a complex interplay between sexual orientation and food insecurity among adults living in New York City. Findings suggest that efforts to connect LGB individuals to public assistance programmes such as Supplemental Nutritional Assistance Program, as well as providing information and connections to food assistance through local LGBTQ+ centres, government agencies (i.e., NYC Human Resources Administration) and non-profit organisations (i.e., Food Bank for New York City) may be beneficial approaches to alleviate food insecurity among this population.
Religious Elite Cues, Internal Division, and the Impact of Pope Francis' Laudato Si'
Authors: Buckley David T. 
Published: December 2020

AbstractWhat impact do cues from religious elites have on followers, particularly when religious communities are internally divided? Could religious elites promote internal consensus, or would their cues stoke further internal polarization? This article utilizes the release of Pope Francis's encyclical on the environment, Laudato Si', to explore these questions. A unique survey experiment, conducted on a nationally representative sample of Catholic voters in the United States in late 2015, tests the impact of Francis' message relative to a similar message from unidentified environmental elites. In keeping with other studies of Laudato's impact in the United States, findings reveal real, but nuanced, effects from Francis' environmental cue. The Francis cue did impact conservatives and high religiosity Catholics, but these effects were not distinct from those on other Catholics in the sample, suggesting limitations in promoting consensus. Instead, responses to a Francis cue varied sharply depending on pre-existing views of Francis' leadership.
Space Weather as the Nexus of Applied and Fundamental Space Science: The Need for Separate Funding Mechanisms and Definition
Authors:   Space Weather Editors
Published: December 2020

AbstractThis editorial aims at highlighting the importance of keeping space science and space weather fundamental and applied research highly interconnected, but also separate through distinct funding mechanisms. Fundamental and applied space research endeavors are not the same, even though they may share some of the same science regions and approaches, and scientists.
Coinfection and infection duration shape how pathogens affect the African buffalo gut microbiota
Authors: Sabey Kate A , Song Se Jin , Jolles Anna , Knight Rob , Ezenwa Vanessa O 
Published: December 2020

Abstract
Changes in the gut microbiota during pathogen infection are often predicted to influence disease outcomes. However, studies exploring whether pathogens induce microbiota shifts have yielded inconsistent results. This suggests that variation in infection, rather than the presence of infection alone, might shape pathogen–microbiota relationships. For example, most hosts are coinfected with multiple pathogens simultaneously, and hosts vary in how long they are infected, which may amplify or diminish microbial shifts expected in response to a focal pathogen. We used a longitudinal anthelmintic treatment study of free-ranging African buffalo (Syncerus caffer) to examine whether (i) coinfection with bovine tuberculosis (Mycobacterium bovis, TB) and gastrointestinal nematodes, and (ii) the duration of TB infection, modified effects of single pathogens on the gut microbiota. By accounting for the interaction between TB and nematodes, we found that coinfection affected changes in microbial abundance associated with single infections. Furthermore, the duration of TB infection predicted more microbiota variation than the presence of TB. Importantly, coinfection and infection duration had nearly as much influence on microbial patterns as demographic and environmental factors commonly examined in microbiota research. These findings demonstrate that acknowledging infection heterogeneities may be crucial to understanding relationships between pathogens and the gut microbiota.
Systems biology drug screening identifies statins as enhancers of current therapies in chronic lymphocytic leukemia
Authors: Gimenez Neus , Tripathi Rupal , Giró Ariadna , Rosich Laia , López-Guerra Mònica , López-Oreja Irene , Playa-Albinyana Heribert , Arenas Fabian , Mas José Manuel , Pérez-Galán Patricia , Delgado Julio , Campo Elias , Farrés Judith , Colomer Dolors 
Published: December 2020

AbstractChronic lymphocytic leukemia (CLL) is a B lymphoid malignancy highly dependent on the microenvironment. Despite new targeted therapies such as ibrutinib and venetoclax, disease progression and relapse remain an issue. CLL cell interactions with the supportive tissue microenvironment play a critical role in disease pathogenesis. We used a platform for drug discovery based on systems biology and artificial intelligence, to identify drugs targeting key proteins described to have a role in the microenvironment. The selected compounds were screened in CLL cell lines in the presence of stromal cells to mimic the microenvironment and validated the best candidates in primary CLL cells. Our results showed that the commercial drug simvastatin was the most effective and selective out of the tested compounds. Simvastatin decreased CLL cell survival and proliferation as well as cell adhesion. Importantly, this drug enhanced the antitumor effect of venetoclax and ibrutinib. We proposed that systems biology approaches combined with pharmacological screening could help to find new drugs for CLL treatment and to predict new combinations with current therapies. Our results highlight the possibility of repurposing widely used drugs such as statins to target the microenvironment and to improve the efficacy of ibrutinib or venetoclax in CLL cells.
Detecting methylation signatures in neurodegenerative disease by density-based clustering of applications with reducing noise
Authors: Mallik Saurav , Zhao Zhongming 
Published: December 2020

AbstractThere have been numerous genetic and epigenetic datasets generated for the study of complex disease including neurodegenerative disease. However, analysis of such data often suffers from detecting the outliers of the samples, which subsequently affects the extraction of the true biological signals involved in the disease. To address this critical issue, we developed a novel framework for identifying methylation signatures using consecutive adaptation of a well-known outlier detection algorithm, density based clustering of applications with reducing noise (DBSCAN) followed by hierarchical clustering. We applied the framework to two representative neurodegenerative diseases, Alzheimer’s disease (AD) and Down syndrome (DS), using DNA methylation datasets from public sources (Gene Expression Omnibus, GEO accession ID: GSE74486). We first applied DBSCAN algorithm to eliminate outliers, and then used Limma statistical method to determine differentially methylated genes. Next, hierarchical clustering technique was applied to detect gene modules. Our analysis identified a methylation signature comprising 21 genes for AD and a methylation signature comprising 89 genes for DS, respectively. Our evaluation indicated that these two signatures could lead to high classification accuracy values (92% and 70%) for these two diseases. In summary, this framework will be useful to better detect outlier-free genetic and epigenetic signatures in various complex diseases and their developmental stages.
Cell non-autonomous requirement of p75 in the development of geniculate oral sensory neurons
Authors: Tang Tao , Donnelly Christopher R. , Shah Amol A. , Bradley Robert M. , Mistretta Charlotte M. , Pierchala Brian A. 
Published: December 2020

AbstractDuring development of the peripheral taste system, oral sensory neurons of the geniculate ganglion project via the chorda tympani nerve to innervate taste buds in fungiform papillae. Germline deletion of the p75 neurotrophin receptor causes dramatic axon guidance and branching deficits, leading to a loss of geniculate neurons. To determine whether the developmental functions of p75 in geniculate neurons are cell autonomous, we deleted p75 specifically in Phox2b + oral sensory neurons (Phox2b-Cre; p75fx/fx) or in neural crest-derived cells (P0-Cre; p75fx/fx) and examined geniculate neuron development. In germline p75−/− mice half of all geniculate neurons were lost. The proportion of Phox2b + neurons, as compared to Phox2b-pinna-projecting neurons, was not altered, indicating that both populations were affected similarly. Chorda tympani nerve recordings demonstrated that p75−/− mice exhibit profound deficits in responses to taste and tactile stimuli. In contrast to p75−/− mice, there was no loss of geniculate neurons in either Phox2b-Cre; p75fx/fx or P0-Cre; p75fx/fx mice. Electrophysiological analyses demonstrated that Phox2b-Cre; p75fx/fx mice had normal taste and oral tactile responses. There was a modest but significant loss of fungiform taste buds in Phox2b-Cre; p75fx/fx mice, although there was not a loss of chemosensory innervation of the remaining fungiform taste buds. Overall, these data suggest that the developmental functions of p75 are largely cell non-autonomous and require p75 expression in other cell types of the chorda tympani circuit.
Epidemiology of a SKin Ulceration Disease (SKUD) in the sea cucumber Holothuria scabra with a review on the SKUDs in Holothuroidea (Echinodermata)
Authors: Delroisse Jérôme , Van Wayneberghe Kévin , Flammang Patrick , Gillan David , Gerbaux Pascal , Opina Noel , Todinanahary Gildas Georges Boleslas , Eeckhaut Igor 
Published: December 2020

AbstractAquacultivated sea cucumbers often suffer from SKin Ulceration Diseases (SKUDs). SKUDs have been observed in six holothuroid species from nine countries. All SKUDs present a similar symptom—the skin ulceration—and can be induced by bacteria, viruses, or abiotic factors. We here provide an update on SKUDs in holothuroids and analyse the case of the SKUD observed in Holothuria scabra in Madagascar. Field observations revealed a seasonality of the disease (i.e. wintertime maximum peak). Morphological analyses of integument ulcers showed that sea cucumbers react by forming a collagen fibre plug. Metagenomic analyses revealed a higher proportion of Vibrionaceae (Gammaproteobacteria) in ulcers in comparison to the healthy integument of the same individuals. Experimental infection assays were performed with ulcer crude extracts and bacteria isolated from these extracts (e.g. Vibrio parahaemolyticus) but did not significantly induce skin ulceration. Our results suggest that the disease is not induced by a pathogen or, at the very least, that the pathogen is not found within the ulcers as the disease is not transmissible by contact. An initial cause of the SKUD in Madagascar might be the repeated and prolonged exposures to cold temperatures. Opportunistic bacteria could settle in the dermis of ulcerated individuals and promote the ulcer extension. We propose a general nomenclature for SKUDs based on the acronym of the disease, the affected sea cucumber species (e.g. Hs for Holothuria scabra), the concerned region using an ISO code 3166-2 (e.g. MG for Madagascar), the description date (e.g. 20 for the year 2020), and, when known, the inducing agent (first letter of the general taxon, b for bacteria, v for virus in currently known cases; a a if it is an abiotic inducing parameter; nothing if the inducing cause has not been precisely identified). The disease described in this work will be designated under the name SKUD Hs-MG-20.
Frequency-diverse multimode millimetre-wave constant-ϵr lens-loaded cavity
Authors: Abbasi M. A. B. , Fusco V. F. , Yurduseven O. , Fromenteze T. 
Published: December 2020

AbstractThis paper presents a physical frequency-diverse multimode lens-loaded cavity, designed and used for the purpose of the direction of arrival (DoA) estimation in millimetre-wave frequency bands for 5G and beyond. The multi-mode mechanism is realized using an electrically-large cavity, generating spatio-temporally incoherent radiation masks leveraging the frequency-diversity principle. It has been shown for the first time that by placing a spherical constant dielectric lens (constant-ϵr) in front of the radiating aperture of the cavity, the spatial incoherence of the radiation modes can be enhanced. The lens-loaded cavity requires only a single lens and output port, making the hardware development much simpler and cost-effective compared to conventional DoA estimators where multiple antennas and receivers are classically required. Using the lens-loaded architecture, an increase of up to 6 dB is achieved in the peak gain of the synthesized quasi-random sampling bases from the frequency-diverse cavity. Despite the fact that the practical frequency-diverse cavity uses a limited subset of quasi-orthogonal modes below the upper bound limit of the number of theoretical modes, it is shown that the proposed lens-loaded cavity is capable of accurate DoA estimation. This is achieved thanks to the sufficient orthogonality of the leveraged modes and to the presence of the spherical constant-ϵr lens which increases the signal-to-noise ratio (SNR) of the received signal. Experimental results are shown to verify the proposed approach.
Antler cannibalism in reindeer
Authors: Mysterud Atle , Ytrehus Bjørnar , Tranulis Michael A. , Rauset Geir Rune , Rolandsen Christer M. , Strand Olav 
Published: December 2020

AbstractPrion diseases constitute a class of invariably fatal and degenerative encephalopathies. Chronic Wasting Disease (CWD) is a contagious prion disease among cervids, which is spreading and causing marked population declines in USA and Canada. The first outbreak of CWD in Europe was discovered in a reindeer population in Norway in 2016. In the worst-case scenario with continental-wide spreading of CWD in Eurasia, an annual harvest of around 4 million cervids is at stake only in Europe, with huge economic and cultural significance. An in situ origin of CWD was suspected, and it appear urgent to identify the likely cause to prevent future emergences. Here, we document the novel phenomenon of extensive antler cannibalism prior to shedding among reindeer in the CWD-infected population. The extent of antler cannibalism increased over the last decades when CWD emerged, and included ingestion of vascularized antlers. Ingestion of tissues from conspecifics is a risk factor for the emergence of prion diseases, where the presence of extensive antler cannibalism opens the intriguing possibility of a ‘Kuru-analogue’ origin of CWD among the reindeer in Europe. Based on general insight on pathology of prion diseases and strain selection processes, we propose an hypothesis for how contagious CWD may emerge from sporadic CWD under the unique epidemiological conditions we document here. More research is required to document the presence of prions in reindeer antlers, and whether antler cannibalism actually led to a strain selection process and the emergence of a contagious form of CWD from a sporadic form of CWD.
Differential diagnosis of vergence and saccade disorders in dyslexia
Authors: Ward Lindsey M. , Kapoula Zoï 
Published: December 2020

AbstractPrevious studies suggest vergence and saccade abnormalities in dyslexic adolescents. However, these studies are mainly clinically based and do not provide objective measurements of eye movements, but rather subjectively evaluate vergence using haplosopic conditions in which the two eyes are dissociated (via polarizers, prisms, or intermittent spectacles). Other studies have identified deficits with binocular coordination during reading in dyslexics. Yet, there are few studies that provide objective measurements of eye movements in the dyslexic population to help provide more information regarding if these deficits could be due to an intrinsic motor problem or if they are the consequence of poor reading. 47 dyslexic adolescents (18 female, 29 male; mean age 15.5) and 44 non-dyslexic adolescents (22 female, 22 male; mean age 14.8) wore a head-based eye tracker (PupilCore, Pupil Labs, Berlin) which recorded wide angle saccade and vergence eye movements at 200 Hz. Tests were run using the REMOBI device, which produced a saccade or vergence audiovisual target. Analysis of eye movements was performed with lab-developed software, AIDEAL. The results showed statistically significant abnormalities in vergence and saccades. In vergence, dyslexics displayed a reduced amplitude of the visually driven portion of convergence and a longer duration in the initial phase of divergence. In saccades, dyslexic adolescents demonstrated slower saccades in both directions. They also had an increased disconjugate drift in the first 80 or 160 ms following saccades to the right, suggesting poor binocular coordination. For both vergence and saccades, the peak velocity and time to peak velocity was higher and earlier, respectively, in non-dyslexics compared to dyslexics; yet the average velocity of both movements was lower in dyslexics. Thus, these results indicate peculiar velocity profiles in dyslexics, particularly a slow deceleration phase in both vergence and saccades. The study provides an objective method to diagnose vergence and saccade abnormalities while viewing targets in the real three-dimensional space in a dyslexic population. Vergence abnormalities are demonstrated to be a problem in dyslexics, occurring independently from reading. We hypothesize these disconjugate drifts following saccades are the result of slow vergence capacity. Rehabilitation programs, such as those using REMOBI, should aim to target these deficits in vergence velocity, as this has been shown to improve binocular control.
COVID-19 cycles and rapidly evaluating lockdown strategies using spectral analysis
Authors: Nason Guy P. 
Published: December 2020

AbstractSpectral analysis characterises oscillatory time series behaviours such as cycles, but accurate estimation requires reasonable numbers of observations. At the time of writing, COVID-19 time series for many countries are short: pre- and post-lockdown series are shorter still. Accurate estimation of potentially interesting cycles seems beyond reach with such short series. We solve the problem of obtaining accurate estimates from short series by using recent Bayesian spectral fusion methods. We show that transformed daily COVID-19 cases for many countries generally contain three cycles operating at wavelengths of around 2.7, 4.1 and 6.7 days (weekly) and that shorter wavelength cycles are suppressed after lockdown. The pre- and post-lockdown differences suggest that the weekly effect is at least partly due to non-epidemic factors. Unconstrained, new cases grow exponentially, but the internal cyclic structure causes periodic declines. This suggests that lockdown success might only be indicated by four or more daily falls. Spectral learning for epidemic time series contributes to the understanding of the epidemic process and can help evaluate interventions. Spectral fusion is a general technique that can fuse spectra recorded at different sampling rates, which can be applied to a wide range of time series from many disciplines.