bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preventing cancer therapy-related heart failure: the need for novel studies
Authors: Fogarassy György , Vathy-Fogarassy Ágnes , Kenessey István , Veress Gábor , Polgár Csaba , Forster Tamás 
Published: September 2020

Aims
After enhancing the survivorship of cancers, the impact of cardiovascular diseases on mortality is increasing among cancer patients. However, anticancer therapies pose a higher cardiovascular risk to patients. As prevention against cancer therapy-induced cardiomyopathy has yet to be explored, the preventive ability of concomitant cardiovascular medications against incident heart failure was assessed.

Methods
A retrospective, population-based study was run using anonymized integration of healthcare databases. All the Hungarian patients diagnosed with breast or colorectal carcinoma and undergoing chemotherapy or biological therapy were analysed. Participants were not treated with any anticancer therapy nor suffered from heart failure/dilated cardiomyopathy during the preceding observational period (≥6.5 years). The heart failure endpoint was established by I50 International Classification of Diseases codes upon discharge from hospital or issuance of an autopsy report.

Results
Among the 9575 patients who were enrolled, the cumulative incidence of heart failure over 4 years was 6.9%. The time until the first heart failure event in the propensity score-matched treated and untreated groups was compared using Cox proportional-hazards models. A significant association between lower heart failure risk and concomitant statin therapy was observed (hazard ratio: 0.748, P = 0.038); the preventive ability was more pronounced in the anthracycline/capecitabine/platinum-treated subgroup (hazard ratio: 0.660, P = 0.032). For angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker therapy, a significantly lower heart failure risk was also observed (hazard ratio: 0.809, P = 0.032). Among beta blockers, nebivolol administered to anthracycline/capecitabine-treated patients was associated with a nonsignificant trend to lower heart failure risk (hazard ratio: 0.584, P = 0.069).

Conclusion
Only concomitant statin and angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker therapies were associated with significantly lower risk of anticancer therapy-related heart failure.
Phenotypic clustering of heart failure with preserved ejection fraction reveals different rates of hospitalization
Authors: Casebeer Adrianne , Horter Libby , Hayden Jennifer , Simmons Jeff , Evers Thomas 
Published: September 2020

Aims
Approximately 50% of patients with heart failure have preserved (≥50%) ejection fraction (HFpEF). Improved understanding of the phenotypic heterogeneity of HFpEF might facilitate development of targeted therapies and interventions.

Methods
This retrospective study characterized a cohort of patients with HFpEF based on similar clinical profiles and evaluated 1-year heart failure related hospitalization. Enrolment, medical and pharmacy data were used to identify patients newly diagnosed with heart failure enrolled in a Medicare Advantage Prescription Drug or commercial healthcare plan. To identify only those patients with HFpEF, we used natural language processing techniques of ejection fraction values abstracted from a linked free-text clinical notes data source. The study population comprised 1515 patients newly identified with HFpEF between 1 January 2011 and 31 December 2015.

Results
Using unsupervised machine learning, we identified three distinguishable patient clusters representing different phenotypes: cluster-1 patients had the lowest prevalence of heart failure comorbidities and highest mean age; cluster-2 patients had higher prevalence of metabolic syndrome and pulmonary disease, despite younger mean age; and cluster-3 patients had higher prevalence of cardiac arrhythmia and renal disease. Cluster-3 had the highest 1-year heart failure related hospitalization rates. Within-cluster analysis, prior use of diuretics (cluster-1 and cluster-2) and age (cluster-2 and cluster-3) was associated with 1-year heart failure related hospitalization. Combination therapy was associated with decreased 1-year heart failure related hospitalization in cluster-1.

Conclusion
This study demonstrated that clustering can be used to characterize subgroups of patients with newly identified HFpEF, assess differences in heart failure related hospitalization rates at 1 year and suggest patient subtypes may respond differently to treatments or interventions.
Sintesis TiO2 terdoping Fe3+ untuk Degradasi Rhodamin B Secara Fotokatalisis dengan Bantuan Sinar Tampak
Authors: Pratiwi Eka , Harlia Harlia , Aritonang Anthoni Batahan 
Published: September 2020

Fotokatalis TiO2 terdoping Fe3+ telah disintesis menggunakan titanium tetraisopropoksida (TTIP) sebagai prekursor serta dopan Fe3+ dari Fe(NO3)3 dengan metode sol-gel. Fotokatalis TiO2 didoping menggunakan Fe3+ bertujuan untuk memperlebar serapan dari sinar Ultra Violet (UV) hingga sinar tampak pada berbagai variasi persentase Fe3+ 0,05%; 0,125%; 0,25% (b/v). karakterisasi fotokatalis dilakukan dengan metode spektrofotometri UV-Vis/DRS, FT-IR, XRD dan diuji aktivitasnya terhadap degradasi rhodamin B. Hasil pengukuran UV-Vis/DRS dari setiap variasi memberikan energi celah pita (Eg) masing-masing sebesar 1,33 eV, 2,11 eV, 2,53 eV. Spektra Infra merah (FT-IR) menunjukkan serapan Fe-O yang merupakan interaksi antara TiO2 dengan dopan Fe3+ dalam struktur TiO2. Hasil pengukuran x-ray difraction (XRD) Fe-TiO2 memberikan difragtogram pada 2θ 25,4773°, 37,9223°, 48,0159° mengindikasikan bahwa Fe3+ telah tersubsitusi kedalam struktur TiO2. Dopan Fe3+ yang telah tersubsitusi juga dapat dibuktikan dari penurunan ukuran rata-rata kristalit dan jarak antar kisi. Hasil Uji Aktivitas konsentrasi dopan Fe3+ 0,125% memiliki aktivitas tertinggi yaitu sebesar 25,605%. Hasil penelitian tersebut menunjukkan bahwa Fe-TiO2 memiliki potensi dalam mendegradasi rhodamin B menggunakan sinar tampak.
Analisis Respons Optis Nanokomposit: Pengaruh Faktor Geometris
Authors: Nugroho Bintoro Siswo , Yulyanto Yulyanto 
Published: September 2020

Pada penelitian ini, dilakukan studi teoritik respons optis sistem nanokomposit yang terdiri dari semiconductor quantum dot (SQD) dan metal nanoparticle (MNP) elips. SQD dimodelkan secara kuantum sebagai three-level system bertipe V sedangkan MNP dimodelkan dalam kerangka teori elektromagnetika klasik. Fokus studi diarahkan pada investigasi pengaruh faktor geometris, yaitu aspek rasio MNP, terhadap modifikasi respons optis nanokomposit. Formalisme density matrix dengan aplikasi persamaan Liouville–von Neumann digunakan untuk menganalisis dinamika optis sistem. Hasil yang diperoleh menunjukkan bahwa variasi aspek rasio MNP dapat menyebabkan modifikasi pada dinamika populasi SQD. Nanokomposit dengan aspek rasio MNP bernilai q=0,5 memiliki frekuensi osilasi populasi yang lebih tinggi dibandingkan nanokomposit dengan q=1,5 . Ditemukan pula bahwa nanokomposit dengan q = 0,5 mencapai keadaan tunaknya pada interval waktu yang lebih lama dibandingkan q=1,5. Optical instability dapat muncul saat nanokomposit dengan dieksitasi dengan medan berintensitas tinggi, I=10^4.7 W/cm^2, Saat fenomena ini terjadi, populasi SQD mengalami osilasi secara lestari dan sistem tidak pernah mencapai keadaan tunaknya.
Construction of Islamic Based Character Education
Authors: Faridi Faridi 
Published: September 2020

This research focuses on the process of understanding the implementation of character education in SMA Negeri 3 Malang through Bedhol Bhawikarsu activities. This activity is organized by and for students in rural communities under the guidance of educators. On one hand, this activity is designed with the hope of internalizing normative values character ​​in students. Therefore, this research will understand the design and implementation of character education models based on normative values. This research uses a qualitative approach to produce descriptive data in the form of written, oral, and observable behaviors. Data were collected by interview, observation, and documentation methods, and then analyzed by interactive analysis of Miles and Hubermann. This research concludes character education through the direct implementation of Bedhol Bhawikarsu in society can internalize values ​​such as the values ​​of honesty, tolerance, religiosity, patriotism, hard work, and independence. These character values ​​are forms of values ​​that are sourced from Islamic values. Therefore, the construction of the character education organization will be able to be realized through activities that unravel many Islamic values ​​to be internalized in students.
Prosesi Pernikahan di Luar Balai Nikah dan Dampaknya terhadap Pendidikan Anak Bagi Masyarakat Gorontalo
Authors: Solong Najamuddin Petta , Arif Muhammad 
Published: September 2020

Artikel ini bertujuan untuk mengungkap dampak positif pernikahan di luar balai nikah. Peristiwa prosesi pernikahan yang secara formal mempertemukan sepasang mempelai atau sepasang calon suami-istri di hadapan penghulu kemudian disahkan secara resmi sebagai suami-istri. Prosesi pernikahan di luar balai nikah umumnya dilangsungkan di rumah keluarga Desa Bumela telah memberikan dampak terhadap pendidikan anak yang ditunjukkan dalam hal anak berpakaian yang bersih dan rapi, berbicara dengan sopan dan tertib, memelihara kebersihan tempat dan lingkungannya serta memiliki tanggungjawab dan menepati janji serta amanah yang diberikan kepada mereka. Selain itu anak menjadi tertanamkan nilai-nilai kekerabatan dalam pernikahan dan kasih sayang di antara keluarga tidak hilang dengan menikahnya anggota keluarga dengan orang lain.
Politik Keagamaan Kolonial: Diskontinuitas dan Kontinuitas di Indonesia
Authors: Ajuba Taufik 
Published: September 2020

Tujuan dari penjajahan Belanda ke Indonesia pertama kalinya adalah menguasai perdagangan rempah-rempah di dunia. Hal seperti ini bisa dilihat dari pembentukan VOC untuk mengorganisir perdangangan rempah-rempah di Indonesia. Keterkaitan dengan gerakan keagamaan di Indonesia, bisa dilihat dari awal kedatangan C. Snouck Hurgroje di Indonesia. Menurut pengamatan C. Snouck Hurgroje, Indonesia menghasilkan beberapa pengumpulan data mengenai pranata-pranata Muhammadan di Hindia Timur yang akan diusahaknya akan bermanfaat bagi Pemerintah Pusat. Dengan semakin lama Belanda menjajah Indonesia, pemerintah Hindia Belanda menghasilkan kebijakan politik etis yang tujuanya adalah untuk menghasilkan pegawai yang bisa mengabdi kepada Hindia Belanda. Kolonialisme yang di gagas oleh pemerintah Jepang justru memberikan perhatian yang lebih terhadap perkembangan Islam di Indonesia, dengan memberikan peranan sosial dan politik yang penting kepada para pemimpin Islam melalui lembaga yang disebutnya Shummukd (Seksi Urusan Keagamaan) yang didirikan di setiap karisidenan
Epistemologi Pendidikan Islam Perspektif Abuddin Nata
Authors: Poloso Ramli 
Published: September 2020

Epistemologi pendidikan Islam Abuddin Nata mengandung muatan humanis yaitu sebuah rumusan pendidikan Islam yang memaksimalkan potensi dan kemampuan akal manusia sebagai makhluk yang sempurna dengan tetap bersandar dan berpijak pada al-Qur‟an dan Sunnah. Pola pendidikan Islam yang humanis tersebut menghendaki pola theo-antropho- centries yaitu memadukan usaha manusia dengan izin dan kehendak Allah swt. Selain itu, Abuddin Nata menginginkan sebuah model pendidikan Islam yaitu pendidikan Islam yang integralistik-konvergensi. Pendidikan Islam integralistik-konvergensi yang dimaksud adalah keterpaduan dan kesatuan antara konsep al-Qur‟an dan Sunnah dengan konteks keindonesiaan sehingga mengarah pada satu tujuan mewujudkan kehidupan yang madani.
Islam dan Pluralitas Agama (Studi Analisis tentang Model Pendekatan dalam Dialog Antar Umat Beragama di Indonesia)
Authors: Jufri Andi 
Published: September 2020

The plurality of religion is an inevitable phenomenon, and every religion emerges in a plural environment. If the pluralistas of these religions are not addressed appropriately, they will potentially lead to problems of vulnerability and conflict between religious communities, and this fact has already happened to monotheistic religions. To find a solution to the conflict between religious communities there needs to be the right approaches. What are the approaches used in efforts to break up conflicts between religious believers?
This paper wants to uncover the problem of religious plurality in Indonesia and several approaches that can be used as role models in building dialogue between religious communities.
Standar Penilaian Kompetensi Pedagogik Guru Pendidikan Agama Islam di SMA Negeri 1 Tapa
Authors: Huntojungo Sitti Masturiwaty 
Published: September 2020

Teacher pedagogic competence has an important role in the quality of learning. Every teacher must be able to master the indicators that exist in pedagogical competence, to achieve the quality of learning. The purpose of this study was to analyze the process of implementing teacher pedagogical competency assessment standards and their impact on the performance of Islamic Religious Education teachers at State Senior High School 1 Tapa. The research method uses descriptive qualitative.
Research shows that: 1) the implementation of pedagogical competency assessment standards for Islamic Religious Education teachers has not been carried out by existing indicators. The mismatch was found between the observations of learning and the value of each indicator obtained. Every value from each learning indicator should be an implementation of each learning indicator. 2) there is an overlap in every indicator that exists in other aspects of pedagogical competence, it should be related to each indicator in each aspect. 3) every indicator of pedagogical competence has not been maximally implemented. 4) the impact of the implementation of pedagogical competency assessment standards on the performance of Islamic Religious Education teachers has positive and negative effects both for teachers, students, and schools.
Evaluasi Sistem Pendidikan Multikultural dalam Pengembangan Diri Peserta Didik di SMP Negeri 1 Kota Gorontalo
Authors: Bempa Manti S , Pido Asiah T 
Published: September 2020

Multicultural education offers alternatives through strategic applications and educational concepts based on the use of diversity in people's lives, especially students, such as ethnic, cultural, linguistic, religious, and racial diversity. This study aims to describe the evaluation steps of the multicultural education system in the self-development of students in junior high schools Negeri 1 Gorontalo City. The method used is a qualitative approach, with observation and interview techniques.
The results showed that the steps in evaluating the multicultural education system in student self development used the Countenance Stake evaluation model approach: 1) The initial steps focus on the symptoms or phenomena that were evaluated according to the K'13 Revised 2017; 2) Collect information based on the characteristics of basic competencies in KI-1 and KI-2; 3) Entering the description data in the matrix framework in this case using the assessment format; 4) Process data analysis on a matrix framework using assessment standards; and 5) Make a report about the results of the analysis
Tafsir Tarbawi: Analisis Bahasa dan Sastra al-Qur’an dalam Surah Luqman
Authors: N. Hula Ibnu Rawandhy 
Published: September 2020

This study aims to uncover the interpretation of tarbawi>, as one of the features / interpretations approached by the analysis of language and literature. The object of his research was examined from Surah Luqman verses 12 to 19, which generally contain messages and educational values. This type of research is library research, by reading, taking notes, identifying the text content of the Surah Luqman and then analyzing it from three aspects,, 1) language analysis/ lugawi>, 2) literature analysis/ bala>gi> and 3) analysis of educational values/tarbawi>.
The results showed that the language content contained in Surah Luqman had depth and diversity of meanings, contained in several words: al-hakim/al-hikmah, al-fis}a>l/al-fit}a>m, al-wa’z|, bunayya, al-wahn/al-d}a’f, al-tus}a’ir, al-marh /al-farh, al-mukhta<l, al-qasd dan al-gad}d}. As for the literary aspect, it contains a number of beauty editors and their meanings, namely: al-tiba>q, s}i>gah al-muba>lagah, zikr al-khas}s{ ba’da al-‘a>mm, al-tams}i>l, al-muqa<balah, al-taqdi>m wa al-ta’khi>r, al-tatayammum, dan al-istia>’rah al-tams|i>liyah, While the value of education consists of: Faith Values, worship values ​​and moral values, which consist of: not shirk, establishing prayer, enjoin the good and forbid the evil, good association, thanks giving, patience, filial piety, not exulting overmuch, arrogant and not self-conceited boaster.
Rasio Neutrofil-Limfosit pada Covid-19; Sebuah tinjauan literatur
Authors: Amanda Devinqa Adhimah 
Published: September 2020

Pada akhir bulan Desember 2019 di Wuhan didapati sekelompok pasien dibawa ke rumah sakit dengan diagnosis awal berupa pneumonia disertai dengan etiologi yang belum diketahui. Setelah diteusuri kembali, mereka memiliki keterkaitan dengan pasar tradisional di Wuhan yang menjual makanan laut dan beberapa satwa. Setelah diidentifikasi SARS-CoV2 merupakan penyebabnya, dengan penyakit yang disebut COVID-19. Batuk dan demam adalah gejala klinis utama dari COVID-19. Pada umumnya gejala klinis COVID-19 dialami ringan, namun terdapat beberapa pasien seiring berjalan penyakit jatuh ke kondisi yang berat. Rasio neutrofil-limfosit diketahui memiliki kemampuan untuk menggambarkan proses derajat penyakit dalam berbagai situasi klinis. Peningkatan rasio neutrofil-limfosit dapat digunakan sebagai penanda prognosis yang independen pada pasien COVID-19. Penilaian rasio neutrofil-limfosit dapat dijadikan sebagai pertimbangan dalam menentukan penanganan yang lebih tepat pada pasien sehingga meningkatkan kapasitas klinisi dalam evaluasi pasien COVID-19. Abstract: At the end of December 2019 in Wuhan, a cluster of patients were admitted to the hospital with initial diagnosis as pneumonia with the etiology remained unknown. After being traced back, they were linked to the traditional market in Wuhan that sell seafood and some animals. SARS-CoV2 was identified as a cause of this condition, with COVID-19 is the name of the disease. Both cough and fever are the main clinical symptoms of COVID-19. In general, clinical symptoms of COVID-19 is mild, but there were some patients as the disease progresses fall into severe conditions. The neutrophil-lymphocyte ratio is known to have the capability to describe the degree of disease in many clinical conditions. The escalation in the neutrophil-lymphocyte ratio is used as an independent marker for prognosis inpatient of COVID-19. Assessment of neutrophil-lymphocyte ratio could be taken into consideration in determining the more appropriate treatment inpatient thereby increasing the capacity of clinicians in the evaluation of COVID-19 patients.
Pengaruh pemberian jus wortel terhadap penurunan skala nyeri dismenore primer pada remaja putri
Authors: Ariyanti Vivi Dwi , Veronica Septika Yani , Kameliawati Feri 
Published: September 2020

Based on the data from the World Health Organization (WHO) in 2018, the number of dysmenorrhea cases in the world is very large. The results of a preliminary study conducted at SMA Negeri 1 Seputih Mataram, Central Lampung showed that from 10 teenage girls who experience menstrual pain, a total of 2 teenage girls complained of pain with a mild pain level, 6 teenage girls complained of pain with a moderate pain level, and 2 teenage girls complain of pain with a severe pain level. This research aims to determine the effect of carrot juice consumption on the reduction of primary dysmenorrhea pain levels in teenage girls at SMA Negeri 1 Seputih Mataram, Central Lampung in 2020. The type of this research is a quantitative research with a pre-experimental design namely one-group pretest, one-group posttest design which is given to 20 people by using accidental sampling technique and by giving carrot juice twice a day with 4 hours interval from the first administration. The bivariate test used in this study was the Wilcoxon test. The results of the research show that there is an effect of carrot juice consumption to reduce dysmenorrhea pain (p value 0,001 less than 0.05). It is recommended for health workers to be able to make carrot juice as one of the teenage girls reproductive health treatment programs in order to reduce dysmenorrhea pain. It is expected that the results of this research can be used as a source of information and implementation for the students/teenage girls in an effort to reduce the levels of dysmenorrhea pain through the consumption of carrot juice.
Karakteristik kasus covid-19 klaster reaktif di lokasi non fasilitas kesehatan (Wisma Asrama Haji)
Authors: Zulisda Z 
Published: September 2020

Awal tahun 2020 pandemi Covid-19 memasuki wilayah Indonesia yang sebelumnya pandemi yang sama mengguncang kota Wuhan Tiongkok, dan hingga saat ini beberapa wilayah terjangkit dalam waktu tidak terlalu lama berubah menjadi wilayah zona merah. Provinsi Kepulauan Bangka Belitung pun mengalami hal serupa, sekitar pertengahan bulan Maret 2020 terkonfirmasi di Kabupaten Basel satu kasus, disusul oleh Kabupaten Belitung, Kota Pangkalpinang, Kabupaten Bangka dan akhirnya seluruh Kabupaten Kota di wilayah Provinsi terpapar Covid-19. Tujuan dari penelitian ini yaitu untuk mengetahui karakteristik pasien Covid19 reaktif yang dikarantina di non fasilitas kesehatan (Wisma Asrama Haji). Data yang diolah merupakan data sekunder bersumber dari Dinas Kesehatan Provinsi Bangka Belitung dengan periode waktu Maret – Juli 2020. Adapun untuk dapat mencapai tujuan penelitian, metode yang digunakan antara lain : metode statistik deskriptif dan visualisasi grafik. Wisma Asrama Haji merupakan sarana yang diberdayakan untuk menampung pasien covid-19 reaktif dari seluruh kluster, sebelumnya tercatat tempat non fasilitas kesehatan sampai pada awal bulan Juni fasilitas kamar penuh. Lonjakan kasus Covid-19 (kasus reaktif) di Bangka Belitung terjadi di awal bulan Juni, untuk menampung semua kasus tersebut, Dinas Kesehatan Provinsi kembali membuka fasilitas karantina khusus atau wisma karantina kluster reaktif di gedung Asrama Haji dengan kapasitas 70 kamar. Setiap kamar disediakan hanya untuk satu orang penghuni atau kasus. Melalui proses karantina di wisma karantina ini, penyebaran kasus Covid-19 di Babel dapat dikendalikan secara bertahap, hingga sekarang kasus Covid-19 baik kasus reaktif maupun kasus terkonfirmasi mulai mereda, hanya 1-3 kasus dalam perawatan saat ini.