bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distinct clinicopathological differences between early gastric cardiac and non-cardiac carcinomas: A single-center retrospective study of 329 radical resection cases
Authors: Wang Yaohui , Li Xiu Qing , Gao Li Li , Wang Chen Xi , Zhang Yi Fen , Huang Qin 
Published: October 2020

Abstract
BackgroundEarly gastric carcinoma is heterogeneous and can be divided into early gastric cardiac carcinoma (EGCC) and early gastric non-cardiac carcinoma (EGNCC) groups. At present, differences in clinicopathology remains obscure between EGCC and EGNCC fundus-corpus and antrum-angularis-pylorus subgroups, especially between EGCC with and without oesophageal invasion.MethodsIn this study, we studied 329 consecutive early gastric carcinoma radical gastrectomies with 70 EGCCs and 259 EGNCCs.ResultsCompared to the EGNCC antrum-angularis-pylorus (n=181), but not fundus-corpus (n=78), sub-group, EGCC showed significantly older age, lower prevalence of the grossly depressed pattern, better tumor differentiation, higher percentage of tubular/papillary adenocarcinoma, but lower frequency of mixed poorly cohesive carcinoma with tubular/papillary adenocarcinoma, and absence of lymph node metastasis (LNM) in tumors with invasion up to superficial submucosa (SM1). In contrast, pure poorly cohesive carcinoma was less frequently seen in EGCCs than in EGNCCs, but mixed poorly cohesive carcinoma with tubular/papillary adenocarcinomas was significantly more common in the EGNCC antrum-angularis-pylorus sub-group than in any other group. No significant differences were found between EGCC and EGNCC sub-groups in gender, tumor size, H. pylori infection rate, and lymphovascular/perineural invasion. EGCC with oesophageal invasion (n=22), compared to EGCC without (n=48), showed no significant differences in the H. pylori infection rate and oesophageal columnar, intestinal, or pancreatic metaplasia, except for a higher percentage of the former in size > 2 cm and tubular differentiation.ConclusionsThere exist distinct clinicopathologic differences between EGCC and EGNCC sub-groups; EGCC was indeed of gastric origin. Further investigations with larger samples are needed to validate these findings.
Prevalence of heavy episodic drinking and associated factors among adults residing in Arba Minch health and demographic surveillance site: a cross sectional study
Authors: Gutema Befikadu Tariku , Chuka Adefris , Ayele Gistane , Tariku Eshetu Zerhun , Aschalew Zeleke , Baharu Alazar , Degefa Nega , Gurara Mekdes Kondale 
Published: October 2020

Abstract
Background: Alcohol consumption is associated with different types of illnesses; particularly heavy episodic drinking is one of the risk factors for the disease burden of alcohol intake. The aim of the study was to assess the prevalence of heavy episodic drinking and associated factors in Arba Minch Health and Demographic Surveillance Site (HDSS).Methods: A community-based cross-sectional study was conducted in 2017 among adult residents of Arba Minch HDSS. Using Arba Minch HDSS database, 3368 individuals were selected by simple random sampling techniques. From WHO STEPS instruments, step one was applied for this study. Variables with a p-value of less than 0.10 for bivariate analysis entered into a multivariable logistic regression model to outline the independent predictors of the heavy episodic drinking. To assess the presence of an association between dependent and independent variables, a p-value of less than 0.05 was considered.Results: The prevalence of heavy episodic drinking was 13.7% (95% CI: 12.6–14.9). The study has shown that heavy episodic drinking was significantly associated with occupation (daily laborer [AOR=0.49; 95% C.I: 0.29–0.85] and housewives [AOR=0.63; 95% C.I: 0.45–0.88] compared with farmers), wealth index (2nd quintiles [AOR =0.55; 95% C.I: 0.41–0.74) and 3rd quintiles [AOR = 0.66; 95% C.I: 0.46–0.93] compared with 1st quintiles), and climatic zone (midland [AOR=1.80;95% CI: 1.11–2.93), highland [AOR=1.95;95% CI: 1.19–3.18] compared with lowland). In addition, tobacco use [AOR=4.28;95% CI: 3.38–5.43], and khat use [AOR=4.75; 95% CI: 2.66–8.50) were also associated with heavy episodic drinking among the study participants. Conclusions: More than one in ten adults reported heavy episodic drinking in the study area. Intervention programs that aim to prevent heavy episodic drinking should be designed appropriately for individuals from lower wealth status, and for highlander.
Effect of artificial tears on dynamic optical quality in patients with dry eye disease
Authors: Wei Zhenyu , Su Yuandong , Su Guanyu , Baudouin Christophe , Labbé Antoine , Liang Qingfeng 
Published: October 2020

Abstract
Background : In clinical practice, fluctuating vision or decreased quality of vision is a common complaint in dry eye patients. Our study was designed to investigate the change in dynamic optical quality in dry eye patients after the use of artificial tears. Methods : Fifty-nine patients with dry eye disease (DED) and 31 healthy age- and sex-matched control subjects were included in this prospective case-control study. Clinical evaluation of the ocular surface included Ocular Surface Disease Index (OSDI), tear film break-up time (TBUT), lipid layer thickness (LLT), and Schirmer I test. DED patients were divided into two groups, mild (31 patients) and severe (28 patients). The optical quality of the tear film was measured with the Optical Quality Analysis System (OQAS) using the mean objective scatter index (mean OSI), standard deviation of objective scatter index (SD-OSI) and modulation transfer function cut-off (MTF cut-off). After baseline examinations, one drop of artificial tears (ATs, carboxymethylcellulose ophthalmic solution, 0.5%) was instilled in both eyes, and optical quality parameters were measured again at 5 and 30 minutes following application of ATs. Results: At baseline, the mean OSI was higher in the DED group (0.95 ± 0.54) than in controls (0.54 ± 0.23, P <0.001). The SD-OSI was also significantly increased in DED patients (0.44 ± 0.71) compared to control subjects (0.12 ± 0.06, P =0.003). Five minutes after AT instillation, mean OSI and SD-OSI decreased significantly in severe DED patients (P =0.044; P =0.018), remained unchanged in mild DED patients, and increased in the control group ( P =0.019; P <0.001). Thirty minutes after AT instillation, no significant difference in optical quality parameters was observed among the three groups. Conclusion : The effect of ATs on optical quality in patients with DED may differ according to the severity of the disease. Measurement of optical quality might be a promising tool to evaluate the effects of various ATs and possibly individualize treatment in DED patients.
Association between training experience and readiness for advance care planning among healthcare professionals: a cross-sectional study&nbsp;
Authors: Chan Helen Yue-lai , Kwok Annie Oi-ling , Yuen Kwok-keung , Au Derrick Kit-sing , Yuen Jacqueline Kwan-yuk 
Published: October 2020

Abstract
Background: Training has been found effective in improving healthcare professionals’ knowledge, confidence, and skills in conducting advance care planning (ACP). However, the association between training and its actual practice in the clinical setting has not been well demonstrated. To fill this gap, this paper examines the association between their readiness for ACP, in terms of perceived relevancy of ACP with their clinical work, attitudes toward and confidence and willingness to perform it, based on the Theory Planned Behavior and relevant training experiences.Methods: An online survey about experiences about ACP of healthcare professionals, including physicians, nurses, social workers, and allied healthcare professionals, currently working in hospital and community care in Hong Kong was conducted. Results: Of 250 respondents, approximately half (51.6%) had received ACP-related training. Those with relevant training reported significantly more positive in the perceived clinical relevance, willingness, and confidence in conducting ACP and different levels of agreement with 19 out of the 25 statements in a questionnaire about attitudes toward ACP than those without (ps ≤ 0.001–0.05). Respondents who received training only in a didactic format reported a significantly lower level of confidence in conducting ACP than did others who received a blended mode of learning (p = 0.012). Notwithstanding significant differences between respondents with and without relevant training, respondents generally acknowledged their roles in initiating conversations and appreciated ACP in preventing decisional conflict in surrogate decision-making regardless of their training experience.Conclusions: This paper revealed the association between training and higher level of readiness toward ACP among healthcare professionals. The findings showed that training is a predictor of their readiness for ACP in terms of perceived relevancy, willingness, and confidence. Those who had received training were less likely to consider commonly reported barriers such as time constraints, cultural taboos, and avoidance among patients and family members as hindrances to ACP implementation.
Cost-effectiveness of paclitaxel, doxorubicin, cyclophosphamide and trastuzumab versus docetaxel, cisplatin and trastuzumab in new adjuvant therapy of breast cancer in china.
Authors: XU Qiaoping , Yuanyuan LI , Jiejing ZHU , Jian Liu , Qingyu LI , Lingya Chen , Ying LUO , Changchen SHI , Yangling LI , Wei YAN 
Published: October 2020

Abstract
Background: Breast cancer is the most common cancer among women in China. Amplification of the Human epidermal growth factor receptor type 2 (HER2) gene is present and overexpressed in 18–20% of breast cancers and historically has been associated with inferior disease-related outcomes. There has been increasing interest in de-escalation of therapy for low-risk disease. This study analyzes the cost-effectiveness of Doxorubicin/ Cyclophosphamide/ Paclitaxel/ Trastuzumab (AC-TH) and Docetaxel/Carboplatin/Trastuzumab(TCH) from payer perspective over a 5 year time horizon.Methods: A half-cycle corrected Markov model was built to simulate the process of breast cancer events and death occurred in both AC-TH and TCH armed patients. Cost data came from studies based on a Chinese hospital. One-way sensitivity analyses as well as second-order Monte Carlo and probabilistic sensitivity analyses were performed.The transition probabilities and utilities were extracted from published literature, and deterministic sensitivity analyses were conducted.Results:We identified 41 breast cancer patients at Hangzhou First People’s Hospital, among whom 15(60%) had a partial response for AC-TH treatment and 13 (81.25%) had a partial response for TCH treatment.No cardiac toxicity was observed. Hematologic grade 3 or 4 toxicities were observed in 1 of 28 patients.Nonhematologic grade 3 or 4 toxicities with a reverse pattern were observed in 6 of 29 patients. The mean QALY gain per patient compared with TCH was 0.25 with AC-TH, while the incremental costs were $US13,142.The incremental cost-effectiveness ratio (ICER) of AC-TH versus TCH was $US 52,565 per QALY gained.Conclusions: This study concluded that TCH neoadjuvant chemotherapy was feasible and active in HER2-overexpressing breast cancer patients in terms of the pathological complete response, complete response, and partial response rates and manageable toxicities.
Responses of forest carbon and water coupling to thinning treatments from leaf to stand scales in a young montane pine forest
Authors: Wang Yi , Campo Antonio D. del , Wei Xiaohua , Winkler Rita , Liu Wanyi , Li Qiang 
Published: October 2020

Abstract
Background
Water-use efficiency (WUE) represents the coupling of forest carbon and water. Little is known about the responses of WUE to thinning at multiple spatial scales. The objective of this research was to use field measurements to understand short-term effects of two thinning treatments (T1: 4,500 stems ha -1 ; and T2: 1,100 stems ha -1 ) and the control (NT:27,000 stems ha -1 )on WUE at the three spatial scales (leaf level: the ratio of leaf photosynthesis to leaf transpiration; tree-level: tree growth to tree transpiration; and stand level: net primary production (NPP)to stand transpiration) and intrinsic WUEi (the ratio of leaf photosynthesis to stomatal conductance at leaf-level; andNPP to canopy conductance at stand-level) in a 16-year old natural lodgepole pine forest. Leaf-level measurements were conducted in 2017, while tree- and stand-level measurements were conducted in both 2016 (the normal precipitation year) and 2017 (the drought year).

Results
The thinning treatments did not significantly affect the tree- and stand-level WUE in the normal year of 2016. However, the thinning significantly affected WUE in the drought year of 2017: T2 exhibited significantly higher tree-level WUE (0.49 mm 2 kg -1 ) than NT (0.08 mm 2 kg -1 ), and compared to NT, the stand-level WUE values in the thinned stands (T1 and T2) were significantly higher, with means of 0.31, 0.56 and 0.70 kg m -3 , respectively. However, the leaf-level and stand-level WUEi in the thinned stands in the drought year were significantly lower than those in the unthinned stands. No significant differences in the leaf-level WUE were found among the treatments in 2017. In addition, the thinning did not significantly change the WUE-VPD relationships at any studied spatial scale.

Conclusions
The thinning treatments did not cause significant changes in all studied WUE metrics in a normal year. However, their effects were significantly promoted under the drought conditions probably due to the decrease in soil water availability,demonstrating that thinning can improve WUE and consequently support forests to cope with the drought effects. The inconsistent results on the effects of the thinning on forest carbon and water coupling atthe spatial scales and the lack of the consistent WUE metrics constraint across-scale comparison and transferring of WUE.
N/OFQ modulates orofacial pain induced by tooth movement through CGRP-dependent pathways
Authors: Yan Xinyu , Han Han , Zhang Shizhen , Lu Yanzhu , Ren Linghuan , Tang Yufei , Li Xiaolong , Jian Fan , Wang Yan , Long Hu , Lai Wenli 
Published: October 2020

Abstract
Background: Nociceptin/orphanin FQ (N/OFQ) has been revealed to play bidirectional roles in orofacial pain modulation. Calcitonin gene-related peptide (CGRP) is a well-known pro-nociceptive molecule that participates in the modulation of orofacial pain. We aimed to determine the effects of N/OFQ on the modulation of orofacial pain and on the release of CGRP. Methods: Orofacial pain model was established by ligating springs between incisors and molars in rats for the simulation of tooth movement. The expression level of N/OFQ was determined and pain level scored in response to orofacial pain. Both agonist and antagonist of N/OFQ receptor were administered to examine their effects on pain and the expression of CGRP in trigeminal ganglia (TG). Moreover, gene therapy based on the overexpression of N/OFQ was delivered to validate the modulatory role of N/OFQ on pain and CGRP expression.Results: Tooth movement elicited orofacial pain and an elevation in N/OFQ expression. N/OFQ exacerbated orofacial pain and upregulated CGRP expression in TG, while UFP-101 alleviated pain and downregulated CGRP expression. N/OFQ-based gene therapy was successful in overexpressing N/OFQ in TG, which resulted in pain exacerbation and elevation of CGRP expression in TG. Conclusions: N/OFQ exacerbated orofacial pain possibly through upregulating CGRP.
Alcohol consumption and associated risk factors in Burkina Faso: results of a population-based cross-sectional survey.
Authors: Bonnechère Bruno , Samadoulougou Sékou , Cissé Kadari , Tassembedo Souleymane , Kouanda Séni , Kirakoya-Samadoulougou Fati 
Published: October 2020

Abstract
Background: Lifestyle modifiable risk factors are a leading preventable cause of non-communicable diseases (NCDs). Amongst them, alcohol and tobacco consumption are the most important. Studies characterizing the prevalence of alcohol consumption in low-income countries are lacking. This study describes the prevalence of alcohol use in Burkina Faso and its associated factors separately for urban and rural residents.Methods: Data from the 2013 Burkina Faso World Health Organization (WHO) Stepwise approach to Surveillance (STEPS) were analyzed. The prevalence of alcohol consumption over the last 30 days were recorded and recoded into categories according to WHO recommendations: low alcohol consumption (<40g alcohol/day for men, <20g for women), mid alcohol consumption (between 40 and 59.9g/day for men and between 20 and 39.9g for women) and a heavy consumption (>60g/day for men and 40g for women). Logistic regression analyses identified factors associated with alcohol consumption use. Results: In the whole population 3,559 (75.8% [72.5 – 78.7]) were not consuming any alcohol, 614 (12.9% [10.9 – 15.3]) had a low alcohol consumption, 399 (8.5% [7.1 – 10.1]) a mid alcohol consumption and 120 (2.7% [2.0 – 3.7]) a high consumption. Age was associated with alcohol intake with a gradient effect, older people having a higher risk (AOR = 2.31 [1.68 – 3.17] for the 55 – 64 years old compared to 25 – 34 group). Tobacco consumption was also significantly associated with alcohol intake with a gradient effect, those with higher tobacco consumption being at higher risk of abusive alcohol intake. When analyzing the risk of having abusive consumption in those consuming alcohol, we found a highly significant gender effect, with males having an increased risk (AOR = 2.53 [1.38 – 4.68]).Conclusion: Our data showed an important burden of alcohol consumption in Burkina Faso with a strong relationship with age, gender and tobacco consumption and disparities across the different regions of Burkina Faso. To effectively reduce alcohol consumption in Burkina Faso, a comprehensive control program should consider these associated factors.
Research on simulation in radiography education: a scoping review protocol
Authors: Vestbøstad Mona , Karlgren Klas , Olsen Nina Rydland 
Published: October 2020

Abstract
Background: Today there are fewer opportunities for health care students and staff for skills training through direct patient contact. The World Health Organization therefore recommends learning about patient safety through hands-on experience and simulation. Simulation has the potential to improve skills through training in a controlled environment, and simulation has positive effect on knowledge and skills, and even patient related outcomes. Reviews addressing the use of simulation across the different radiography specialties are lacking. Further knowledge on simulation in radiography education is needed to inform curriculum design and future research. The purpose of this scoping review is to explore, map and summarize the extent, range and nature of published research on simulation in radiography education.Methods: We will follow the methodological framework for scoping reviews originally described by Arksey and O’Malley. We will search MEDLINE, Embase, Epistemonikos, The Cochrane Library, ERIC, Scopus, and sources of grey literature. A comprehensive search strategy for Ovid MEDLINE was developed in collaboration with a research librarian. An example of a full electronic search from the Ovid MEDLINE (1641 articles records, 09.01.2020) is provided and will be used to adapt the search strategy to each database. Two independent review authors will screen all abstracts and titles, and full-text publications during a second stage. Next, they will extract data from each included study using a data extraction form informed by the aim of the study. A narrative account of all studies included will be presented. We will present a simple numerical analysis related to the extent, nature and distribution of studies, and we will use content analysis to map the different simulation interventions and learning design elements reported. Any type of simulation intervention within all types of radiography specializations will be included. Our search strategy is not limited by language or date of publication. Discussion: An overview of publications on simulation in radiography education across all radiography specialties will help to inform future research and will be useful for stakeholders within radiography education using simulation, both in the academic and clinical setting.
Exploration of the mechanism of Ziyin Tongluo Formula on preventing and treating postmenopausal osteoporosis based on the network pharmacology and molecular docking
Authors: Chen Rong-Bin , Yang Ying-Dong , Sun Kai , Liu Shan , Guo Wei , Zhang Jin-Xin , Li Yong 
Published: October 2020

Abstract
Background: Postmenopausal osteoporosis (PMOP) is a global chronic and metabolic bone disease, which poses huge challenges to individuals and society. Ziyin Tongluo Formula (ZYTLF) has been proved effective in the treatment of PMOP. However, the material basis and mechanism of ZYLTF against PMOP have not been thoroughly elucidated.Methods: Online databases were used to identify the active ingredients of ZYTLF and corresponding putative targets. Genes associated with PMOP were mined, and then mapped with the putative targets to obtain overlapping genes. Multiple networks were constructed and analyzed, from which the key genes were selected. The key genes were imported to the DAVID database to performs GO and KEGG pathway enrichment analysis. Finally, AutoDock Tools and other software were used for molecular docking of core compounds and key proteins. Results: Ninety-two active compounds of ZYTLF corresponded to 243 targets, with 129 target genes interacting with PMOP, and 50 key genes were selected. Network analysis showed the top 5 active ingredients including quercetin, kaempferol, luteolin, scutellarein, and formononetin., and the top 50 key genes such as VEGFA, MAPK8, AKT1, TNF, ESR1. Enrichment analysis uncovered two significant types of KEGG pathways in PMOP, hormone-related signaling pathways (estrogen , prolactin, and thyroid hormone signaling pathway) and inflammation-related pathways (TNF, PI3K-Akt, and MAPK signaling pathway). Moreover, molecular docking analysis verified that the main active compounds were tightly bound to the core proteins, further confirming the anti-PMOP effects. Conclusions: Based on network pharmacology and molecular docking technology, this study initially revealed the mechanisms of ZYTLF on PMOP, which involves multiple targets and multiple pathways.