bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antimicrobial Resistance and Molecular Epidemiology of Staphylococcus aureus Causing Bloodstream Infections at Ruijin Hospital in Shanghai from 2013 to 2018
Authors: Gu Feifei , He Weiping , Xiao Shuzhen , Wang Su , Li Xinxin , Zeng Qian , Ni Yuxing , Han Lizhong 
Published: April 2020

AbstractStaphylococcus aureus or methicillin-resistant Staphylococcus aureus (MRSA) is an important issue associated with significant morbidity and mortality and well known as a predominant pathogen causing bloodstream infection (BSIs) globally. To estimate the antibiotic resistance and molecular characteristics of S. aureus causing BSIs in Shanghai, 120 S. aureus isolates (20 isolates each year) from the patients with S. aureus BSIs from 2013 to 2018 were randomly selected and enrolled in this study. Fifty-three (44.2%) MRSA isolates were determined, and no isolate was found resistant to vancomycin, daptomycin, synercid, linezolid and ceftaroline. The toxin genes tst, sec, seg and sei were found more frequently among MRSA isolates compared with MSSA isolates (all P < 0.0001). Twenty-nine sequence types (STs) were identified, and ST5 (23.3%) was the most common ST, followed by ST398 (11.7%) and ST764 (10.0%). SCCmec II (73.6%) was the most frequent SCCmec type among MRSA isolates. The dominant clonal complexes (CCs) were CC5 (ST5, ST764, ST965 and ST3066; 36.7%) and the livestock-associated clone CC398 (ST398, 11.7%). MRSA-CC5 was the predominant CC among MRSA isolates (37/53, 69.8%), and CC5-II MRSA was found in 34 isolates accounting for 91.9% (34/37) among CC5 MRSA isolates. In addition, all 29 tst-positive MRSA isolates were CC5-MRSA as well. Our study provided the properties and genotypes of S. aureus causing BSIs at Ruijin Hospital in Shanghai from 2013 to 2018, and might suggest of value clues for the further study insights into pathogenic mechanisms intrinsically referring to the development of human-adapted S. aureus clones and their diffusions.
Trehalose metabolism confers developmental robustness and stability in Drosophila by regulating glucose homeostasis
Authors: Matsushita Ryota , Nishimura Takashi 
Published: April 2020

AbstractOrganisms have evolved molecular mechanisms to ensure consistent and invariant phenotypes in the face of environmental fluctuations. Developmental homeostasis is determined by two factors: robustness, which buffers against environmental variations; and developmental stability, which buffers against intrinsic random variations. However, our understanding of these noise-buffering mechanisms remains incomplete. Here, we showed that appropriate glycemic control confers developmental homeostasis in the fruit fly Drosophila. We found that circulating glucose levels are buffered by trehalose metabolism, which acts as a glucose sink in circulation. Furthermore, mutations in trehalose synthesis enzyme (Tps1) increased the among-individual and within-individual variations in wing size. Whereas wild-type flies were largely resistant to changes in dietary carbohydrate and protein levels, Tps1 mutants experienced significant disruptions in developmental homeostasis in response to dietary stress. These results demonstrate that glucose homeostasis against dietary stress is crucial for developmental homeostasis.
Breaking Down Silos: Interprofessional Collaborative Practice in Humanitarian Audiology
Authors: Bondurant Lindsay M. 
Published: April 2020

AbstractThe goal of humanitarian healthcare is to improve health outcomes and patient quality of life in under-resourced areas. One avenue for improvement may be via interprofessional collaborative practice, which allows providers from multiple specialties to work together to promote positive interventions for the communities they serve. The purpose of this article is to provide a general framework for incorporating interprofessional collaborative practice within a humanitarian audiology project.
The impact of penalties for wrong answers on the gender gap in test scores
Authors: Coffman Katherine B. , Klinowski David 
Published: April 2020

Significance
Scholars and policy-makers have been wrestling with the question of how to increase the representation of women in STEM fields. Our evidence from a large-scale policy change on the national college entry exam in Chile points to one factor that impacts the gender gap in test scores among highly talented students. Simply removing penalties for wrong answers reduces a sizeable gender gap in questions skipped. And, in doing so, this policy change narrows the gender gap in test scores, primarily among high-achievers and in the fields of chemistry, social science, and mathematics. If strong test scores are a prerequisite to a career in STEM, it may be that this type of policy change generates increased opportunity for aspiring female scientists.
A khóra e alhures: uma observação sobre a eskhatiá na Electra de Eurípides
Authors: Ribeiro Márcia Cristina Lacerda 
Published: April 2020

Eurípides (485 a.C.- 406 a.C.) levou aos palcos do teatro de Atenas uma releitura sui generis do mito de Electra por volta de 415 a.C. O poeta transpôs com engenhosidade toda a trama para o espaço rural e acrescentou um personagem fundamental no desenrolar da peça, o ancião, preceptor de Agamenão. Expulso da ásty pelo tirano Egisto, o ancião habita o limite fronteiriço da cidade e exerce atividade agropastoril em sua propriedade. Nosso objetivo é examinar a fazendola do fiel servo da família Atrida, localizada em uma eskhatiá. Diferentemente de alguns estudos modernos que veem essas terras limítrofes como improdutivas ou destinadas exclusivamente às atividades marginais, a exemplo da caça e da extração da lenha, ou um apêndice quase isolado da pólis, perfilamos com pesquisas que veem a eskhatiá como espaço integrante da pólis, espaço complexo, plural, muitas vezes absolutamente produtivo
Formal Assessment of Teamwork Among Cancer Health Care Professionals in Three Large Tertiary Centers in Nigeria
Authors: Ibraheem Abiola F. , Giurcanu Mihai , Sowunmi Anthonia Chima , Awolude Olutosin , Habeebu Muhammad , Popoola Abiodun , Sanni Felix , Agaga Luther A. , Olopade Olufunmilayo , Polite Blase N. 
Published: April 2020

PURPOSE There are strategies to bring quality cancer care to underserved patients, but poor use of the principles of teamwork is a major barrier to achieving quality services. The intent of this study was to assess teamwork as perceived by health care workers caring for patients with cancer. METHODS We conducted a survey among health care professionals in cancer care at 3 tertiary centers in southwestern Nigeria from July to November 2016. Respondents rated teamwork using the Safety Attitudes Questionnaire; we focused on the teamwork climate subscale comparing health care providers and institutions using analysis of variance and on collaboration using logistic regression. RESULTS Three hundred seventy-three professionals completed the survey: 177 physicians (47%), 51 nurses (14%), 21 pharmacists (6%), 31 laboratory technicians (8%), and 88 others (24%); 5 (1%) participants had missing professional information. The average teamwork climate score across all professionals in the study was 70.5 (SD = 24.2). Pharmacists rated the teamwork climate the lowest, with a mean score of 63.9 (SD = 29.5); nurses and laboratory technicians rated teamwork higher, with means of 74.5 (SD = 21.7) and 74.2 (SD = 27.1), respectively; and physicians rated teamwork 66.0 (SD = 23.6). Collaboration with other health care providers was reported as poorer by physicians compared with nurses and pharmacists. CONCLUSION Although overall teamwork scores were consistent with ambulatory studies in the United States, important subgroup variations provide targets for intervention. Physicians rated collaboration as poor both intra- and interprofessionally. Pharmacists rated interprofessional teamwork with nurses as poor. Efforts to transform cancer care must focus on building trust among the key stakeholders. This is critical in low-resource settings, which must maximize the use of limited resources to improve patient outcomes.
Analysis of psychiatric consultations in the department of neurology and stroke unit: diagnosis and therapy
Authors: Chmiela Tomasz , Piekarz Paweł , Łabuz-Roszak Beata , Warchala Anna , Krzystanek Ewa , Gorzkowska Agnieszka 
Published: April 2020

Cel pracyCel badania: Celem badania była analiza konsultacji psychiatrycznych u pacjentów Oddziału Neurologii i Oddziału Udarowego (ON/OU) w latach 2017-2018.MetodaDokonano retrospektywnej analizy konsultowanych psychiatrycznie chorych, ustalanych przez konsultanta rozpoznań (wg ICD-10) oraz zalecanej terapii.WynikiW analizowanym okresie odbyło się we wszystkich oddziałach szpitala 719 konsultacji psychiatrycznych, zdecydowana większość, tj. 488 (67,87%) odbyła się w oddziale neurologii i oddziałem udarowym. Najwięcej porad psychiatry wymagali pacjenci z rozpoznaniem choroby Huntingtona (n=25; 37,31%), choroby Parkinsona (n=60; 23,9%) oraz padaczki (n=40; 22,73%). Najczęściej stawianą diagnozą były psychiczne zaburzenia organiczne (n=229; 55,85%), a w szczególności organiczne zaburzenia nastroju (n=73; 14,96%) i organiczne zaburzenia lękowe (n=32; 6,56%), zaś w chorobach naczyniowych - zaburzenia świadomości w przebiegu majaczenia (n=30; 40,54%). Większość konsultacji (n=388; 79,51%) zakończyła się rozpoczęciem lub modyfikacją leczenia farmakologicznego. Grupami najczęściej zalecanych leków były neuroleptyki (n=174; 35,66%), w większości atypowe (n=152; 87,36%), oraz leki przeciwdepresyjne (n=230; 47,13%), w większości SSRI (n=216; 93,91%). U pacjentów >60 r.ż. w porównaniu z chorymi <60 r.ż częściej rozpoznawano zaburzenia organiczne (n=179; 66,30% vs. n=49; 35,0%) i częściej zalecano neuroleptyki (n=131; 42,12% vs. n=44; 24,86%).WnioskiPacjenci oddziału neurologii i oddziału udarowego byli najczęściej konsultowaną psychiatrycznie grupą chorych. Optymalizacja opieki nad osobą ze schorzeniem neurologicznym wymaga ścisłej współpracy neurologa i psychiatry oraz opracowania i aktualizacji wspólnych stanowisk dla postępowania w wybranych jednostkach chorobowych.
Distribución de la pensión de sobrevivientes en los nuevos modelos de familia en Colombia: cónyuge y compañero(a) permanente
Authors: Rodr Luz Mery 
Published: April 2020

El presente artículo de revisión, aborda el estudio de la costumbre inveterada de los seres humanos de tener relaciones de pareja con varios miembros de su comunidad, sean de tipo heterosexual, bisexual u homosexual, y que hasta hace algún tiempo se mantenían en total clandestinidad, han obligado a los legisladores y jueces de la República de los diferentes países a emitir pronunciamiento legal y jurisprudencial que permitan resolver de manera equitativa la pensión de sobrevivientes, entendiendo por este comportamiento, que el trabajador cotizante o pensionado que convive con diferentes parejas tiene como fin último extender su brazo protector a todos por igual. En Colombia se venían haciendo pronunciamientos muy tímidos a través de la legislación y la jurisprudencia, pero a partir de la reforma constitucional de 1991, que incluye la igualdad material, se han hecho avances sustanciales, aceptando nuestra realidad social.

AbstractThe present article of review, it approaches the study of the inveterate custom of the human beings of having relations of pair with several members of his community, be of heterosexual, bisexual or homosexual type, and that up to some time ago were kept in total stealthiness, have forced the legislators and judges of the republic of the different countries to issuing legal and juriprudential pronouncement that they allow to solve in an equitable way the survivors’ pension, understanding for this behavior, that the worker cotizante or pensioned that it coexists with different pairs it has as last end extend his protective arm to all equally. In Colombia they were coming doing very shy pronouncements across the legislation and the jurisprudence, but from the constitutional reform of 1991, which includes the material equality, substantial advances have been done, accepting our social reality.
YÖNETİM KURULU YAPISI VE İHTİYATLILIK: BİST KURUMSAL YÖNETİM ENDEKSİ İMALAT SANAYİ FİRMALARI ÜZERİNE BİR ARAŞTIRMA
Authors: YIKILMAZ ERKOL Aslı 
Published: April 2020

Bu çalışmada, Borsa İstanbul (BİST) kurumsal
yönetim endeksindeki 18 imalat sanayi firmasının 2006-2016 dönemindeki yönetim
kurulu yapısı ile ihtiyatlılık düzeyi arasındaki ilişki incelenmiştir. Yönetim
kurulu büyüklüğü, yönetim kurulu bağımsızlığı, yönetim kurulunda kadın üye
sayısı, CEO ikililiği yönetim kurulu yapısı değişkenleri olarak belirlenmiştir. Firmaların ihtiyatlılık düzeyleri ise negatif
tahakkuk yöntemi ile ölçülmüştür. Elde edilen sonuçlara göre, yönetim kurulu
büyüklüğü ve CEO’nun aynı zamanda yönetim kurulu üyesi olması firmaların
ihtiyatlılık düzeyini negatif yönde etkilemektedir. Buna karşın kuruldaki bağımsız
üye sayısı ile ihtiyatlılık düzeyi arasında pozitif ilişki vardır. CEO’nun aynı
zamanda yönetim kurulu başkanı olması ve yönetim kurulundaki kadın üye sayısı
ile ihtiyatlılık düzeyi arasında ise anlamlı bir ilişki tespit edilememiştir.
Determining the Relation of Electromagnetic Radiation with the Level of Cortisol Hormone of Serum (Blood) of the Male Employees of Golestan Province’s 230kV Substations
Authors: Saa’di Jalal Al-Din , Ranjbarian Mohammad , Etemad Koroush , Farhadi Rozita , Zarei Fatemeh 
Published: April 2020

Introduction: Today the rate of human beings exposed to electromagnetic fields is increasing deliriously and human beings are being more drowned in the ocean of electromagnetic fields each day. It has been a long time that the effects of electromagnetic fields on organisms has been studied by researchers and due to the long-term researches and the slow impact of fields on life-cycle processes, in a lot of cases a final opinion is impossible. Considering the detrimental effects of being exposed to electromagnetic radiations, this study aimed to determine the relation between electromagnetic radiations and the level of Melatonin and Cortisol hormones of serum (blood) of the male employees of the 230kV substations in Golestan Province.

Materials and Methods: this study has been accomplished with the cross sectional method (descriptive-analytic) on male employees of the 230 kilo-Volt substations in Golestan Province(1396). The results achieved from the serum sample of the case and control groups have been compared, and the measurements and the relation between them has been analyzed, using Spss22 software.

Results: 100 % of the measured electric field intensity and magnetic flux density of the 230kV substations in Golestan Province is less than Iran’s occupational limits. There was no significant difference between the average of the level of Cortisol hormone in the case and control groups. The average of the level of Cortisol in the substation job group was not significantly different. There is no significant difference in the average of Cortisol level and age category and work place
Conclusion: Electromagnetic radiations do not affect the level of Cortisol hormones of the male employees of the 230 kV substations in Golestan province and the electric and magnetic fields intensity of substations is in the occupational limits of Iran.
Analysis of the applicability of steel 20MnCrS5 for gears of the domestic mobile machines
Authors: Rudenko S. P. , Valko A. I. , Sandomirskii S. G. 
Published: April 2020

Evaluation of applicability of 20MnCrS5 steel for gears of transmissions of mobile machines, manufactured according to European standard EN 10084 was carried out. Experimental and virtual simulation of hardenability of the steel according to the updated method was realized. The assessment of the applicability of 20MnCrS5 case-hardening steel for gears of the domestic mobile machines was made by the criterion of obtaining the cross section of the tooth structures with a hardness 32 HRC for core, 50 HRC for semi-conversion zone, 61–63 HRC for the diffusion layer excluding other physical and mechanical properties of steel.It is established that at the content of alloying elements close to the maximum limit, the use of this steel is possible for gears with a module up to 10 mm.
MIIP downregulates PD-L1 expression through HDAC6 in malignant melanoma
Authors: Xing Ruwei , Li Ting , Xiang Lijie , Liu Haotian , Wei Junqiang , Lu Jia , Yang Jilong 
Published: April 2020

Abstract
Background Immune checkpoint inhibitors have improved the objective response rate and survival of melanoma patients. However, there are still many melanoma patients suffering from disease progression due to primary or secondary immune checkpoint inhibitor resistance, as is observed in the failure of anti-PD1/PD-L1 therapy. It is urgent to determine the function of PD-1/PD-L1 expression in melanoma and its associated pathways to enhance the efficacy of anti-PD-1 therapies. Methods A cohort of 133 patients with histologically confirmed melanoma from Tianjin Medical University Cancer Institute & Hospital were included in this study. We performed immunohistochemical staining to detect the expression of MIIP, HDAC6 and PD-L1. Kaplan-Meier and log-rank test were used for survival analyze. As for vitro, Western blot was used to verify the signaling pathway that MIIP regulates PD-L1 expression. Results Our present data demonstrate MIIP expression was decreased in melanoma and that the negative expression of MIIP was correlated with worse overall survival. We also found the positive expression of HDAC6, a molecule that is downstream of MIIP, had a positive trend with decreased overall survival, because the p value was not statistically significant. At the same time, the positive expression of PD-L1, a crucial costimulatory molecule, was associated with decreased overall survival. Furthermore, there was a positive association between HDAC6 and PD-L1 protein expression (p<0.01). In vitro experiment, we found that increasing MIIP led to decreased HDAC6, pSTAT3, and PD-L1 expression. Knocking down MIIP led to increased HDAC6, pSTAT3, and PD-L1 expression. Combining the published results, showing that HDAC6 can regulate PD-L1 expression through STAT3, our present data suggest that MIIP inhibits the expression of PD-L1 by downregulating HDAC6 in melanoma. Most importantly, methods for targeting MIIP-HDAC6-PD-L1 pathways, such as treatment with HDAC6 inhibitors, might indicate a new therapeutic approach for enhancing immune checkpoint inhibitor therapies in melanoma. Conclusions Our findings highlight the immunomodulatory effects of MIIP in the inhibition of PD-L1 expression by downregulating HDAC6 in melanoma. Our data provide a sensible framework to consider the targeting of the MIIP-HDAC6-PD-L1 pathway.
GATA6 regulates epithelial-mesenchymal transition and metastasis through regulating MUC1/β-catenin pathway in cholangiocarcinoma
Authors: Deng Xiang , Jiang Peng , Chen Jian , Li Jianwei , Li Dajiang , He Yu , Jiang Yan , Zhang Yujun , Xu Shuangnian , Li Xi , Wang Shuguang , Tian Feng 
Published: April 2020

Abstract
The authors have requested that this preprint be removed from Research Square.
Application of 3D tooth model for monitoring of implant space and inter-root distance without radiographs: A proof of concept study
Authors: Park Mirinae , Lee Kyung-Min 
Published: April 2020

Abstract
Background Radiographs are integral for evaluating of implant space and inter-root distance. The purpose of this report is to introduce a method for evaluating 3D root position with minimal radiation using 3D tooth model which is composed of intraoral-scanned crown and CBCT-scanned root. Materials and methods An intraoral scan and CBCT scan of the patient were obtained before treatment. In the CBCT image, tooth segmentation was performed by isolating individual tooth from the maxillary and mandibular alveolar bone using software program. By combining segmented individual tooth with the intraoral scan, consequently, 3D tooth model was fabricated. Results After treatment, the additional intraoral scan at post-treatment was integrated into the tooth model and the resulting position of the root could be predicted without additional radiographs. It is possible to monitor the root position using 3D tooth model without the need for additional radiographs after a pretreatment CBCT scan. Conclusion The application of 3D tooth model benefits the patient by reducing radiation exposure while providing the clinician with a precise treatment evaluation for monitoring tooth movement.
Релаксация тока в монокристаллах TlGa-=SUB=-1-x-=/SUB=-Dy-=SUB=-x-=/SUB=-Se-=SUB=-2-=/SUB=- (x=0.01; 0.03)
Authors: Мустафаева С.Н. , Гусейнова К.М. , Асадов М.М. 
Published: April 2020

Abstract The low-temperature relaxation processes in TlGa_1 – _ x Dy_ x Se_2 ( x = 0.01, 0.03) single crystals have been studied experimentally. The physical parameters which characterize the electron processes in Ag–TlGa_1 – _ x Dy_ x Se_2–Ag samples have been determined using the estafette transfer mechanism of the charge formed at deep traps due to the carrier injection from a contact: the effective mobility of the charge transferred due to deep centers, the sample contact capacity, the region of accumulation of the charge in the samples, the contact charging constant, and the flight time of charge carriers through the sample.
PEMBERIAN EKSTRAK REBUNG DAN PUPUK HORMON TANAMAN UNGGUL TERHADAP PERTUMBUHAN DAN PRODUKSI KACANG HIJAU (Vigna radiata L)
Authors: Mardaleni Mardaleni , Sutriana Selvia 
Published: April 2020

The objective of this research was to know the effect of giving bamboo shot extract and superior plant hormone fertilizer on growth and yield of mung bean. The research was conducted at the experimental farm Faculty of Agriculture Riau Islamic University Pekanbaru. The research was arranged using a completely randomized design with two factorials. The first factor used bamboo shoot dosage (R) with four level treatment: without extract (R0), 1,5 ml/l water (R1), 3,5 ml/l water (R2), and 4,5 ml/l water (R3), and the second factor used superior plant hormone plant doses (H) with four level treatment: without hormone (H0), 2 cc/l water (H1), 4 cc/l water (H2), and 6 cc/l water (H3). The parameter observed consisted of pant height, flower age, harvest age, pod number per plot, pod weight per plot, and weight of 100 seeds. Data analyzed by using statistic and BNJ test at the 5% significance level. Interactionally, the application of bamboo shot extract and superior plant hormone fertilizer showed a significant effect on shoot height and number of pod per plant with the best treatment 4.5 ml/l water of shoot extract and 6 cc/l water of pant hormone. Individually, the application of bamboo shot extract affected significantly on height plant, harvest age, and weight of 100 seeds with the best dosage of 4.5 ml/l water and the application of superior plant hormone fertilizer influenced significantly on pant height, flower age, and pod weight per plant with the best dosage of 6 cc/l water.
اثر انموذجي جود لافويه ومارتوريلا في اكتساب المفاهيم البلاغية والاحتفاظ بها لدى طالبات الصف الخامس الادبي
Authors: أ. م. د. زهور كاظم مناتي  
Published: April 2020

هدفت الدراسة الحالية إلى تعرف اثر انموذجي جود لافويه ومارتوريلا في إكتساب المفاهيم البلاغية والاحتفاظ بها لدى طالبات الصف الخامس الادبي .
بلغت عينة البحث (91) طالبة، وقد صاغت الباحثة (65) هدفاً سلوكياً على وفق تصنيف بلوم ( Bloom ) في المجال المعرفي ضمن مستوياته الستة .
وبعد معالجة البيانات باستعمال تحليل التباين الأحادي توصلت الدراسة إلى النتائج الآتية :
1- تفوق طالبات المجموعة التجريبية الأولى الآتي درسن البلاغة والتطبيق باستعمال انموذج جود لافويه على طالبات المجموعة الضابطة الآتي درسن بالطريقة الاعتيادية في إكتساب المفاهيم البلاغية والاحتفاظ بها .
2- تفوق طالبات المجموعة التجريبية الثانية الآتي درسن البلاغة والتطبيق باستعمال انموذج مارتوريلا على طالبات المجموعة الضابطة الآتي درسن بالطريقة التقليدية في إكتساب المفاهيم البلاغية والاحتفاظ بها .