bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flu Viral Multiplex Testing and its Implication for COVID-19 Testing
Authors: Han Aaron , Hicban Janet 
Published: September 2020

Background:
The diagnosis of viral causes for flu-like syndromes have positively been impacted by the availability of molecular assays. In recent years,
syndromic multiplex panels have been able to give rapid turn-around-times and highly accurate results. We examine the use of this test during the
first four months of 2020 during the COVID-19 pandemic.

Methods:
A retrospective review of 2145 patient results from a multiplex syndromic flu panel using Biofire RP2 was performed. Cases in which parallel
testing for COVID-19 by real-time polymerase chain reaction (RT-PCR) was compared.

Results:
53% of the patients tested identified as a viral agent. 13% of the positive cases were coinfection with more than a single virus. The most frequently
detected virus(es) were rhinovirus/enterovirus, followed by coronaviruses (non-MERS, non-COVID-19). One hundred patients had simultaneous
testing for COVID-19. Seventeen (17%) had positive COVID-19 by RT-PCR. Three of these patients had coinfection with rhinovirus/enterovirus
and COVID-19. The negative predictive value for COVID-19 based on a positive non-COVID agent was 95% in our sample.

Conclusions:
Viral syndromic panels are useful for the rapid detection and appropriate treatment of patients. Our results suggest coinfection is infrequent, and
we discuss the impact of COVID-19 on patient testing strategy. The use of multiplex panels is useful to provide accurate diagnosis and rule out
important pathogens that have different treatment approaches.
Anti-Breast Cancer Activities of Ketoprofen-RGD Conjugate by Targeting Breast Cancer Stem-Like Cells and Parental Cells
Authors: Noori Shokoofe , Rajabi Sadegh , Tavirani Mostafa R. , Shokri Bahare , Zarghi Afshin 
Published: September 2020

Background:
Cancer Stem Cells (CSCs) play an important role in various stages of cancer development,
advancement, and therapy resistance. Ketoprofen-RGD has been revealed to act as an anti-cancer agent
against some tumors.

Objective:
We aimed to explore the effects of a novel Ketoprofen-RGD compound on the suppression of Breast
Cancer Stem-like Cells (BCSCs) and their parental cells.

Methods:
Mammospheres were developed from MCF-7 cells and assessed by CSC surface markers through
flowcytometry. The anti-proliferative and pro-apoptotic activities of Ketoprofen-RGD were measured by MTS
assay and flowcytometry. The expression levels of stemness markers and JAK2/STAT proteins were measured by
quantitative Real Time-PCR (qRT-PCR) and western blotting, respectively. Intracellular Reactive Oxygen Species
(ROS) was measured using a cell permeable, oxidant-sensitive fluorescence probe (carboxy-H2DCFDA).

Results:
Ketoprofen-RGD significantly reduced the mammosphere formation rate and the expression of three
out of six stemness markers and remarkably decreased viability and induced apoptosis of spheroidal and parental
cells compared to controls. Further experiments using CD95L, as a death ligand, and ZB4 antibody, as an
extrinsic apoptotic pathway blocker, showed that Ketoprofen-RGD induced intrinsic pathway, suggesting a
mechanism by which Ketoprofen-RGD triggers apoptosis. ROS production was also another way to induce
apoptosis. Results of western blot analysis also revealed a marked diminish in the phosphorylation of JAK2 and
STAT proteins.

Conclusion:
: Our study, for the first time, elucidated an anti-BCSC activity for Ketoprofen-RGD via declining
stemness markers, inducing toxicity, and apoptosis in these cells and parental cells. These findings may suggest
this compound as a promising anti-breast cancer.
Comparative DFT Study of 5-Fluorouracil Adsorption on Silica and Graphene for Bio-Medical Applications
Authors: Simonetti Sandra , Grau Emilia Noseda , Roman Gabriel , Ulacco Sandra 
Published: September 2020

Aims:
The administration of antitumor 5-Fluorouracil (5-FU) into the human body is generally
accomplished via a central venous catheter that is prone to degradation when it comes in contact
with bodily fluids or aggressive drugs such as 5-Fu. Therefore, degradation could be reduced by applying
protective coatings onto the internal and/or external surfaces of the catheters.

Objectives:
Graphene and silica materials could be promising coating materials because of their low reactivity
and antimicrobial properties. The mechanisms of interaction between the carrier and the drug
are based on surface chemistry related phenomena. Understanding the physicochemical features of the
surfaces is a fundamental step to describe and predict the strength of these interactions and may result
in controlled adsorption and release processes.

Methods:
Computational DFT methods can provide an important aspect by providing atomistic details
of the drug adsorbed on the surfaces through molecular modeling.

Results:
DFT calculations of the binding energy, charge exchange and orbital population of 5-FU adsorbed
on graphene and silica materials confirmed weak interactions between the drug and the solid
surfaces that could favor desorption during the drug delivery. Graphene and silica surfaces do not react
with the 5-FU molecule behaving as inert materials and the drug does not suffer from degradation nor
alter its structure during adsorption on both the materials.

Conclusion:
These characteristics, in addition to biocompatibility and antimicrobial properties, suggest
that graphene and silica could be used as promising internal/external coating materials for biomedical
applications.
Indian Sign Language Recognition on PYNQ Board
Authors: Singh Sukhendra , Rathna G. N. , Singhal Vivek 
Published: September 2020

Introduction:
Sign language is the only way to communicate for speech-impaired people. But this sign
language is not known to normal people so this is the cause of barrier in communicating. This is the problem faced by
speech impaired people. In this paper, we have presented our solution which captured hand gestures with Kinect camera
and classified the hand gesture into its correct symbol.

Method:
We used Kinect camera not the ordinary web camera because the ordinary camera does not capture its 3d
orientation or depth of an image from camera however Kinect camera can capture 3d image and this will make
classification more accurate.

Result:
Kinect camera will produce a different image for hand gestures for ‘2’ and ‘V’ and similarly for ‘1’ and ‘I’
however, normal web camera will not be able to distinguish between these two. We used hand gesture for Indian sign
language and our dataset had 46339, RGB images and 46339 depth images. 80% of the total images were used for training
and the remaining 20% for testing. In total 36 hand gestures were considered to capture alphabets and alphabets from A-Z
and 10 for numeric, 26 for digits from 0-9 were considered to capture alphabets and Keywords.

Conclusion:
Along with real-time implementation, we have also shown the comparison of the performance of the various
machine learning models in which we have found out the accuracy of CNN on depth- images has given the most accurate
performance than other models. All these resulted were obtained on PYNQ Z2 board.
Pengaruh Kepemilikan Manajerial, Kepemilikan Institusional, Kepemilikan Asing, dan Ukuran Perusahaan terhadap Kinerja Modal Intelektual (Studi Empiris pada Perusahaan Perbankan yang Terdaftar di Bursa Efek Indonesia Tahun 2015-2017)
Authors: Hartati Des Rini , Syofyan Efrizal , Taqwa Salma 
Published: September 2020

The purpose of this study was to determinate the effect of firm size and ownership structure such as manajerial ownership, institutional ownership and foreign ownership towards intellectual capital performance. The method of this study is quantitative. The population in this study was banking sector company in Indonesia Stock Exchange in 2015 until 2017.The sample of this study determined by purposive sampling. Data analysis techniquefor hypothesis testing using multiple regression analysis. The result of this research showed that ownership structure such as manajerial ownership, institutional ownership and foreign ownership have no significant effect while firm size has positive and significant effect to intelectual capital performance. This happens because the proportion of manajerial ownership is low and the institution investor more focused on maximizing profit as short term goals so institution investor seing IC as charges rather than expenses of investment-generating future economic benefit.Based on the results oh this study, it can be suggested that: (1) Company should increase their asset in regard to increase the firm size so company had more financial funding to manage their IC performance and create more value added, and (2) For further researcher, it is suggested to increase the number of sample companies, add other variables and use other proxy in subsequent research.Keywords: Foreign ownership; Intellectual capital performance; Institutiona ownership; Managerial ownership
Thesis Overview Invariance and Same-Equivariance Measures for Convolutional Neural Networks
Authors: Quiroga Facundo , Lanzarini Laura 
Published: September 2020

The main contributions of this thesis include:

A comparative analysis of Neural Network based models for sign language handshape classification.
An analysis of strategies to achieve equivariance to rotations in neural networks for:

Comparing the performance of strategies based on data augmentation and specially designed networks and layers.
Determining strategies to retrain networks so that they acquire equivariance to rotations.

A set of measures to empirically analyze the equivariance of Neural Networks, as well as any other model based on latent representations, and the corresponding:

Validation of the measures to establish if they are indeed measuring the purported quantity. Analysis of the different variants of the proposed measures. Analysis of the properties of the measures, in terms of their variability to transformations, models and weight initialization.
Analysis of the impact of several hyperparameters of the models on the structure of their equivariance, including Max Pooling layers, Batch Normalization, and kernel size. Analysis of the structure of the equivariance in several well known CNN models such as ResNet, All Convolutional and VGG. Analysis of the impact on the equivariance of using specialized models to obtain equivariance such as Transformational Invariance Pooling.
Analysis of the class dependency of equivariance. Analysis of the effect of varying the complexity and diversity of the transformations on the measures.
Implementación de Modelo pedagógico para integrar TIC en el tercer nivel de Educación Parvularia
Authors: Fernández Chávez Carolina Del Carmen , Fuentes Riffo Karina Andrea , Salcedo Lagos Pedro 
Published: September 2020

El estudio expuesto a continuación da cuenta de los resultados obtenidos al implementar un modelo para integrar TIC en Educación Parvularia. Este tiene como finalidad innovar las prácticas pedagógicas de las educadoras de párvulos al incorporar las tecnologías en la enseñanza. La intervención se desarrolló en un colegio privado, donde participaron 16 educadoras y 160 niños y niñas que asistían a los niveles de transición. El proyecto se dividió en tres etapas: a) El diagnóstico, para conocer el conocimiento teórico de las educadoras en relación a las TIC, b) Implementación del modelo propuesto y c) Análisis de los resultados de las etapas uno y dos.
Los resultados indican una valoración positiva de las TIC al incorporar su uso en la planificación de aula y evaluación, además, la adquisición de recursos tecnológicos con el apoyo de la comunidad educativa, hicieron que esta propuesta fuera motivante y lúdica para los niños.
O ATUAL CENÁRIO DA MULHER NO TRATAMENTO DO CÂNCER DE MAMA: RELATO DE CASO
Authors: DIANA Tayná Freitas , MOL Dalva Alice Rocha 
Published: September 2020

A terapia cognitivo–comportamental é um processo de aprendizagem em que terapeuta e cliente se propõem a analisar a função dos pensamentos e comportamentos inadequados, com o intuito de promover mudanças emocionais e comportamentais duradouras. A intervenção psicoterápica em mulheres com câncer de mama na abordagem cognitivo-comportamental se destaca por ser breve, estruturada, educativa e orientada para problemas atuais de vida do usuário. O presente estudo teve como objetivo identificar sentimentos existentes durante o diagnóstico e tratamento do câncer de mama. Trata-se de um relato de caso de uma paciente com diagnóstico de câncer de mama, em tratamento quimioterápico e radioterápico. Os dados foram coletados e interpretados durante o processo terapêutico, apoiado no referencial da terapia cognitivo–comportamental. Os resultados obtidos no processo terapêutico mostraram sentimentos como: medo, insegurança e a expectativa de enfrentamento do câncer de mama. Concluiu-se que uma das possibilidades de intervenção psicológica é o fortalecimento da autoestima da paciente, uma vez que, durante a terapia cognitivo–comportamental, foram propostas tarefas à paciente para desenvolver estratégias de enfrentamento após o diagnóstico e tratamento do câncer de mama. O apoio psicoterápico possibilitou o enfrentamento de situações de incertezas relacionadas ao tratamento e do medo da recidiva da doença.

THE CURRENT SCENARIO FOR WOMAN UNDER BREAST CANCER TREATMENT: CASE REPORT

ABSTRACT
Cognitive-behavioral therapy is a learning process in which the therapist and patient agree with analyzing inappropriate thoughts and behavioral functions; it aims at promoting long-term emotional and behavioral changes. The physiotherapeutic intervention by using a cognitive-behavioral approach for women with breast cancer draws attention because it is brief, framed, educational, and guided to current issues from the customer's life. The present paper aims to identify feelings that are present during the diagnosis and treatment of breast cancer. It is a case report from a patient diagnosed with breast cancer, under chemotherapy and radiotherapy. Data was collected and interpreted during the therapeutic process, and supported by cognitive-behavioral framework therapy. The results of the therapeutic treatment revealed feelings such as fear, uncertainty, and expectation for tackling breast cancer. It was concluded that one of the possibilities for psychological intervention is to strengthen the patient’s self-esteem, to the extent that during behavioral cognitive therapy, the patient was told to complete some tasks in order to develop confronting strategies after breast cancer diagnosis and treatment. The psychotherapeutic support enabled the patient to deal with uncertainty conditions regarding the treatment as well as the fear of the disease recurrence.

Descriptors: Breast Cancer, Cognitive-behavioral Therapy. Case Report.
PENGARUH PENGGUNAAN MEDIA SOSIAL TERHADAP PERILAKU MEMILIH PEMILIH PEMULA KOTA PADANG PADA PEMILIHAN KEPALA DAERAH KOTA PADANG
Authors: Novita Nina 
Published: September 2020

Fenomena penggunaan media sosial yang meningkat dan sebagian besarnya adalah pemilih pemula yang aktif dalam bermedia sosial dapat memengaruhi pilihan pemilih pemula dalam pemilihan umum. Penelitian ini menggunakan teori uses and gratification dengan tiga variabel bebas, yaitu penggunaan media sosial Collaboractive Project (X1), penggunaan media sosial Blog and Microblogging dan Social Network (X2), dan penggunaan media sosial Content Comunities (X3) dengan variabel terikat yakni perilaku memilih pemilih pemula pada pemilihan Kepala Daerah Kota Padang tahun 2018. Penelitian ini menggunakan pendekatan kuantitatif desain survey dan tipe penelitian explanatory research. Temuan data di lapangan memperlihatkan bahwa penggunaan media sosial Collaboractive Project (X1), Blog and Microblogging dan Social (X2), dan Content Comunities (X3) tidak memengaruhi perilaku memilih pemilih pemula, dengan nilai Asymp. Sig > 0,05 X1; 0,658, X2; 0,150, dan X3; 0,164. Artinya, Ha ditolak dan H0 diterima.
Home, Sweet Home: Negotiating Intimacy in Brazilian Elitist Closed Condominiums
Authors: Estrada Mejia Rafael Ignacio , Guerrón Montero Carla 
Published: September 2020

This article aims to decrease the cultural invisibility of the wealthy by exploring the Brazilian emergent elites and their preferred living arrangement: elitist closed condominiums (BECCs) from a micropolitical perspective. We answer the question: What is the relationship between intimacy and subjectivity that is produced in the collective mode of existence of BECCs? To do so, we trace the history of the elite home, from the master’s house (casa grande) to contemporary closed condominiums. Following, we discuss the features of closed condominiums as spaces of segregation, fragmentation and social distinction, characterized by minimal public life and an internalized sociability. Finally, based on ethnographic research conducted in the mid-size city of Londrina (state of Paraná) between 2015 and 2017, we concentrate on four members of the emergent elite who live in BECCs, addressing their collective production of subjectivity.
Cultura judaica, diplomacia cultural e as crônicas de viagem de José Lins do Rego em O Globo (1944-1956)
Authors: Hollanda Bernardo Buarque de , Matos Regiane , Santos Leandro Martan Bezerra 
Published: September 2020

Resumo
O artigo debruça-se sobre um segmento da produção de crônicas de viagem de José Lins do Rego, publicadas no jornal O Globo, procurando mostrar como estes escritos jornalísticos foram elevados à condição de livro em meados dos anos 1950, na esteira da visita do escritor ao recém-criado Estado de Israel e do prestígio literário angariado por um romancista recém-eleito à Academia Brasileira de Letras. Ao circunscrever o campo de atuação e circulação de literatos nos periódicos impressos do Rio de Janeiro de meados do século XX, o texto salienta de início os escritos de Lins do Rego nos anos 1940, quando inicia sua colaboração no jornal do amigo Roberto Marinho, em plena Segunda Guerra Mundial, posicionando-se contra os horrores do nazifascismo e manifestando sua solidariedade ao povo judeu, posição reiterada nos anos seguintes, ante a criação do Estado de Israel. Procura-se, em seguida, dar evidências de que tais crônicas estão na base do convite para a viagem ao novo país em 1955, documentada nas páginas do mesmo jornal e transformada em livro bilíngue – português-inglês – no ano seguinte, sob os auspícios do Centro Cultural Brasil-Israel. Para além de um caso isolado, restrito ao paraibano, mobilizamos outros exemplos de intelectuais – Silva Melo, Guilherme de Figueiredo, Câmara Cascudo e Érico Veríssimo – com a defesa do argumento de que o referido Centro Cultural foi o pivô deste trânsito entre as duas nações, ao adotar a estratégia, entre os anos 1950 e 1960, da promoção de viagens de escritores brasileiros ao Oriente Médio, com vistas à projeção da cultura judaica e israelense no país.
Um novo imaginário nacional? O humor gráfico publicado na imprensa independente brasileira durante a progressiva redemocratização
Authors: Toulhoat Mélanie 
Published: September 2020

Neste artigo, propomos uma reflexão sobre os desafios políticos enfrentados por diversas formas de humor gráfico, publicadas em periódicos brasileiros independentes durante a segunda metade da década de 1970. Oriundos dos chamados grupos minoritários, como coletivos homossexuais, movimentos negros e grupos ambientalistas, as reivindicações eram erguidas contra o autoritarismo e a repressão do regime militar, mas também contra o conservadorismo prevalecente dentro dos movimentos de oposição democrática, nas fileiras na esquerda tradicional. A luta contra o preconceito e a convergência dos grupos ocuparam um espaço visual significativo nas páginas do periódico Lampião da Esquina, publicado entre 1978 e 1981. Juntamente com a revista mensal Versus, publicada entre 1975 e 1979, e alguns periódicos que lutavam para preservar a natureza e as terras indigenas, foi um desses projetos editoriais inovadores e militantes que formularam propostas alternativas para um projeto nacional multicultural enraizado na América Latina, como resposta a uma visão do Brasil inserido dentro do bloco ocidental, cristão e alinhado na política dos Estados Unidos.
Revue Franco-Brésilienne (Rio de Janeiro, 1898) Uma aventura parnasiana na Belle Époque tropical
Authors: Guimarães Valeria 
Published: September 2020

O artigo é um estudo sobre a Revue Franco-Brésilienne publicada em fins do século XIX no Rio de Janeiro e que reuniu nomes expressivos da intelectualidade da época. O objetivo desse artigo é analisar um dos periódicos literários que tinha como proposta explícita a cooperação binacional. A análise está focada no papel de alguns de seus editores e colaboradores na consolidação desses vínculos e na constituição de um campo cultural e literário do início do século XX sob uma perpectiva transnacional.
Pulmonary function tests in children with beta-thalassemia major
Authors: Harsoor Jayaraj , Ratageri Vinod H. , Shilpa C. , Illalu Shivanand , Wari Prakash 
Published: September 2020

Objectives:The objective of the study was to study the pattern of lung functions in thalassemia major children and correlation of pulmonary function tests (PFTs) with serum ferritin.Materials and Methods:A hospital-based cross-sectional descriptive study done from January 2017 to December 2017. Inclusion criteria: Children with confirmed diagnosis of beta-thalassemia major in the age group of 5–15 years were included in the study. Exclusion criteria: Already diagnosed cases of pulmonary dysfunctions, CHD and RHD were excluded from the study. All enrolled children underwent a detailed clinical history, physical examination and blood sample were sent for Hb and serum ferritin before blood transfusion (BT). PFT was done within 24 h of BT using spirometer (Helios-401). Statistical analysis was done using SPSS (Version22).Results:Forty-five children enrolled in the study and majority of them were <10 years (37 children) with M:F ratio 1.6:1. The pulmonary dysfunction was present in 35 (77.8%), but none of them had respiratory symptoms. The pulmonary dysfunction observed was restrictive 31 (88.5%), obstructive 2 (5.7%), and combined 2 (5.7%). A reduced forced vital capacity (FVC) % in 33 (73.3%), a reduced forced expiratory volume in the 1stsecond (FEV1%) in 25 (55.5%), a normal FEV1/FVC in 41 (91.2%), and a reduced FEF 25–75% in 23 (51.1%) children were observed. Risk factors such as, age, height, and duration of chelation (>5 years) were significantly associated with pulmonary dysfunction (P< 0.05). There was no correlation between serum ferritin levels and PFT. However, PFT values were found to be decreased in patients with a high serum ferritin (>2500 ng/ml), but these differences were statistically not significant.Conclusion:Abnormal patterns of lung function were common (restrictive type, predominant), even though none of these children had any respiratory symptoms.