bluuebunny/crossref_metadata_2025_split huggingface dataset:
Criteria to Evaluate the Quality of Outcome Reporting in Randomized Controlled Trials of Rehabilitation Interventions
Authors: Wang Dan , Taylor-Vaisey Anne , Negrini Stefano , Côté Pierre 
Published: September 2020

Abstract
No standardized guideline for the reporting of outcomes measures in randomized controlled trials of rehabilitation interventions is currently available. This study includes four phases to identify, synthesize, and make recommendations for potential attributes of reporting criteria of outcome measures in rehabilitation randomized controlled trials. First, we surveyed the author instructions for rehabilitation journals to determine how journals require authors to report outcomes. Second, we reviewed all consolidated standards of reporting trials extensions to determine how other speciality groups require reporting of outcomes in randomized controlled trials. Third, we conducted a focused scoping review to examine the nature and variations of criteria used to evaluate the quality of outcome measures in randomized controlled trials. Finally, we synthesized the information from phases 1–3 and propose four criteria specific to the reporting of outcomes in randomized controlled trials of rehabilitation interventions: (1) clearly describe the construct to be measured as outcome(s); (2) justify the selection of outcome measures by mapping to World Health Organization International Classification of Function, Disability, and Health (International Classification of Functioning) framework; justify the psychometric properties (relevance, validity, reliability) of the selected measurement tool; (3) clearly describe the timing of outcome measurement, with consideration of the health condition, the course of disease, and hypothesized effect of intervention; and (4) complete and unselective reporting of outcome data.
The Association Between Pain Trajectories With Posttraumatic Stress Disorder, Depression, and Disability During the Acute Posttrauma Period
Authors: Connor Julie P. , Brier Zoe M.F. , Price Matthew 
Published: September 2020

ABSTRACT

Objective
Exposure to a traumatic event is common among US adults, yet only a small fraction develops posttraumatic stress disorder (PTSD). Higher pain after a traumatic injury has been associated with higher PTSD symptoms and thus may be a risk factor. However, few studies have examined how pain during the period immediately after a trauma, referred to as the acute posttrauma period, relates later to PTSD outcomes.

Methods
A sample of (n = 87) individuals who had experienced a traumatic injury assessed their pain through daily mobile assessments for the first month after injury. PTSD, depression, and functional impairment were assessed at the time of trauma and 1 and 3 months later.

Results
Using latent class growth analysis, three trajectories of pain were identified: low pain (41.3%), decreasing pain (43.7%), and high pain (14.9%). At baseline, the high-pain class reported higher levels of depression and functional impairment than did the low-pain group. From baseline to 3 months, the low-pain class experienced a reduction in PTSD, depression, and functional impairment, whereas the high-pain class experienced an increase in PTSD symptoms, persistent depression, and functional impairment.

Conclusions
These results demonstrate that there are distinct trajectories of pain after a traumatic injury. Persistent elevated pain is associated with more severe psychopathology in the period immediately after a traumatic injury.
Traditional Versus Virtual Surgery Planning of the Fronto-Orbital Unit in Anterior Cranial Vault Remodeling Surgery
Authors: Ganesh Praveen , Mahipathy Surya Rao Rao Venkata , Rajan Vivakaran Thanga Thirupathi , Sundaramurthy Narayanamurthy , Durairaj Alagar Raja , Jayachandiran Anand Prasath , Nagarjuna Muralidhara 
Published: September 2020

Background:
Craniosynostosis correction surgery is a complex procedure, which involves complete dismantling and reassembly of the cranial vault components. The traditional planning method for these surgeries results in increased intra-operative time owing to its highly subjective nature. The advent of virtual surgical planning (VSP) platform has lead to a greater pre-operative insight and precision outcome in calvarial remodeling surgeries. The purpose of this paper is to evaluate intra-operative time and blood loss difference as a measure of surgical efficiency between VSP based template guided Anterior Cranial Vault Reconstruction (ACVR) with Fronto-Orbital Unit Advancement (FOUA) and the traditional surgeries.

Methods:
Data were collected from patients who underwent ACVR with FOUA in our unit. Patients were divided into 2 groups, Template Fronto-Orbital Unit (TFOU) group and Non-template Fronto-Orbital Unit (NFOU) group. In TFOU group, Virtual planning along with fabrication of Template guide was carried out. Patients undergoing ACVR using traditional techniques were categorized as NFOU group. A comparative prospective analysis was carried out in terms of Intra-operative time duration and blood loss. Student ‘t’ test was used to compare the means of the 2 groups.

Results:
A total of 10 patients were included in the present study. There were 5 control (NFOU) and 5 TFOU cases. There was a significant decrease in the operating time in TFOU group compared to the NFOU group. TFOU group also showed reduced intra-operative bleed compared to the NFOU group.

Conclusion:
Virtual surgical planning (VSP) and 3D modeling with prefabricated template guide augurs reliable outcomes and portends the possibility of lesser intra-operative time. It is a valuable tool, which offers enormous benefits in terms of precise pre-surgical planning with predictive results.
Use of Onlay Hydroxyapatite Cement for Secondary Cranioplasty
Authors: Brussius Coelho Marcio , Rtshiladze Michael , Aggarwala Shivani , Hunt Jeremy , Peltz Tim , Gardner Danielle , Gianoutsos Mark 
Published: September 2020

Background:
Children who undergo bi-fronto-orbital advancement (BFOA) frequently develop a contour deformity on the temporal and supra-orbital region, with an incidence reported as high as 55% and 75%, respectively. Up to 20% of patients may require correction. Hydroxyapatite cement (HAC) is a good alternative to autogenous tissue. The available literature on its use focusses on the reconstruction of bone defects, but little has been published on its efficacy and safety as an onlay graft over intact cranium.

Objectives:
To describe our institution's experience with HAC in the pediatric population.

Methods:
Retrospective chart review from 1998 to 2018 on all patients from the Craniofacial Unit at the Sydney Children's Hospital who had either coronal or metopic craniosynostosis and underwent BFOA and later in life required cranioplasty with HAC for contour repair.

Findings:
We have performed 166 BFOA and nineteen secondary cranioplasties for contour repair using onlay HAC. The mean age at the time of operation was 14 years. Bi-coronal craniosynostosis was most frequently associated with secondary cranioplasty and 37% had an associated syndrome. The mean volume of HAC used was 37 mL. There was only 1 patient who had a complication (5.3%) and required partial removal of allograft. The mean length of admission was 2 days. Mean follow up time of 22.4 months.

Conclusions:
HAC represents a safe option when used correctly, with low rates of complication and satisfactory cosmetic outcomes.
Variations in Postoperative Management of Pediatric Open-Vault Craniosynostosis
Authors: Srivatsa Shachi , Heiman Adee J. , Gray Megan C. , Carpenter Courtney , Patel Ashit 
Published: September 2020

Abstract
Craniosynostosis is the premature fusion of 1 or more of the calvarial sutures causing a secondary distortion of the skull shape due to lack of growth perpendicular to the fused suture and compensatory overgrowth parallel to the suture. Open vault craniosynostosis repair requires extensive dissection and reshaping of the skull and can be associated with significant pain, commonly undervalued, and underreported in the pediatric cohort. Although there is an extensive body of literature focusing on the operative treatment of craniosynostosis, there is little consensus about optimal postoperative management protocols, including pain control regimens. The purpose of this study was to assess variation in immediate postoperative management protocols within the United States. A Qualtrics-based survey was submitted to all 112 American Cleft Palate-Craniofacial Association-approved craniofacial teams regarding their routine postoperative management protocol. Nineteen responses were obtained. All surgeons reported routine post-op intensive care unit stay. Mean overall length of stay was 3.5 days. Pain control agents included acetaminophen (100%), intravenous opioids (95%), oral opioids (79%), and ketorolac (53%). Eighty-eight percent of surgeons reported utilizing vital signs and observational parameters for pain assessment with 47% reporting the use of a formal pain scale. Sixty-three percent of those surveyed used a drain, 88% used a foley catheter, 75% used postoperative prophylactic antibiotics, and 75% routinely used arterial line monitoring postoperatively. The results of this survey will be the basis for future direction in understanding the efficacy of differing management protocols and further study of pain management in the pediatric craniosynostosis population.
Biomechanical Evaluation of Implant Osseointegration After Guided Bone Regeneration With Different Bone Grafts
Authors: Gunes Nedim , Gul Mehmet , Dundar Serkan , Tekin Samet , Bozoglan Alihan , Ozcan Erhan Cahit , Karasu Necmettin , Toy Vesile Elif , Bingül Muhammet Bahattin 
Published: September 2020

AbstractThe aim of this study was to compare the biomechanical osseointegration of titanium implants after guided bone regeneration (GBR) with a hydroxyapatite graft, deproteinized bovine bone graft, human-derived allograft, and calcium sulfate bone graft. Thirty-two female Sprague Dawley rats were divided into four groups, each containing eight (n = 8) rats: hydroxyapatide (HA), deproteinized bovine bone graft (DPBB), allograft (ALG), and calcium sulfate. Bone defects were created in the tibia of the rats, which were grafted with HA, DPBB, ALG, or CP bone grafts for the purpose of GBR. Ninety days after surgery, machine-surfaced titanium implants were inserted into the area where GBR had been undertaken. After 90 days of the surgical insertion of the implants, the rats were sacrificed, the implants with surrounding bone tissue were removed, and biomechanical osseointegration (N/cm) analysis was performed. No statistically significant differences were found among the groups in osseointegration (N/cm) three months after the GBR procedures (P > 0.05). According to the biomechanical results, none of the grafts used in this study was distinctly superior to any of the others.
Spontaneous Bone Flap Resorption Following Cranioplasty Using Autologous Bone
Authors: da Costa Benalia Victor Hugo , Pedrozo Charles Alfred Grander , Kormanski Matheus Kohama , Veiga José Carlos Esteves , de Aguiar Guilherme Brasileiro 
Published: September 2020

Abstract
Cranioplasty is a common neurosurgical procedure. The main reasons for performing cranioplasty are, in addition to aesthetic correction and protection of the brain, the reestablishment of the adequate flow of cerebrospinal fluid and the prevention of complications inherent to the perpetuation of bone failure. In our institution the patient's autologous bone remains the best method for performing cranioplasty, despite the existence of other heterologous grafts and bone substitutes. Despite representing for us, the best material for cranioplasty, the use of autologous grafting is subject to complications. In this paper, the authors present the case of a patient who underwent cranioplasty with autologous bone that progressed with spontaneous resorption of the bone flap. The authors herein briefly discuss the case and review the literature on the subject, with an emphasis on the factors that can lead to such an outcome.
A New Solution for Routine Endoscopic Aerosol-Generating Procedures (AGPs) in the COVID-19 Pandemic
Authors: Gallo Oreste , Locatello Luca Giovanni , Orlando Pietro , Bruno Chiara , Maggiore Giandomenico , Signorini Patrizia , Adembri Chiara 
Published: September 2020

Introduction:
There is urgent need to find a swift and cheap way to safely perform routine endoscopic procedures during the otolaryngological and anesthesiological practice. We want to share our experience of a novel device, inspired by the pediatric head box experience.

Materials and Methods:
Five otolaryngologists and four anesthesiologists were asked to visualize the glottic plane by using the device. A total of 15 attempts was allowed to reach the vocal folds within 60 seconds after entering the box. Student's t-test for unpaired samples was used to compare groups.

Results:
Transnasal laryngoscopy through our endobox could be successfully performed by all the physicians involved and the mean number of attempts before visualizing and passing the glottis for the first time was 2.8 (range 1–5) in the otolaryngologists’ group versus 3.2 (range 1–6) in the anesthesiologists’ group (P=0.583). Out of the 15 attempts, the group of otolaryngologists reached the glottis 10.2 times, on average, against 9.7 in the other group (P=0.692).

Conclusions:
Our endobox seems a practical and feasible strategy to control droplets diffusion during standard ear, nose, and throat and anesthesiological practice.
Reliable detection of focal-onset seizures in the human anterior nucleus of the thalamus using non-linear machine learning
Authors: Toth Emilia , Kumar Sachin S , Chaitanya Ganne , Riley Kristen , Balasubramanian Karthi , Pati Sandipan 
Published: September 2020

AbstractObjectiveThere is an unmet need to develop seizure detection algorithms from brain regions outside the epileptogenic cortex. The study aimed to demonstrate the feasibility of classifying seizures and interictal states from local field potentials (LFPs) recorded from the human thalamus-a subcortical region remote to the epileptogenic cortex. We tested the hypothesis that spectral and entropy-based features extracted from LFPs recorded from the anterior nucleus of the thalamus (ANT) can distinguish its state of ictal recruitment from other interictal states (including awake, sleep).ApproachTwo supervised machine learning tools (random forest and the random kitchen sink) were used to evaluate the performance of spectral (discrete wavelet transform-DWT), and time-domain (multiscale entropy-MSE) features in classifying seizures from interictal states in patients undergoing stereo EEG evaluation for epilepsy surgery. Under the supervision of IRB, field potentials were recorded from the ANT in consenting adults with drug-resistant temporal lobe epilepsy. Seizures were confirmed in the ANT using line-length and visual inspection. Wilcoxon rank-sum (WRS) method was used to test the differences in spectral patterns between seizure and interictal (awake and sleep) states.Main Results79 seizures (10 patients) and 158 segments (approx. 4 hours) of interictal stereo EEG data were analyzed. The mean seizure detection latencies with line length in the ANT varied between seizure types (range 5-34 seconds). However, the DWT and MSE in the ANT showed significant changes for all seizure types within the first 20 seconds after seizure onset. The random forest (accuracy 93.9 % and false-positive 4.6%) and the random kitchen sink (accuracy 97.3% and false-positive 1.8%) classified seizures and interictal states.SignificanceThese results suggest that features extracted from the thalamic LFPs can be trained to detect seizures that can be used for monitoring seizure counts and for closed-loop seizure abortive interventions.
Testing the Ability of Convolutional Neural Networks to Learn Radiomic Features
Authors: Klyuzhin Ivan S. , Xu Yixi , Ortiz Anthony , Ferres Juan Lavista , Hamarneh Ghassan , Rahmim Arman 
Published: September 2020

ABSTRACTBackground and ObjectiveRadiomics and deep learning have emerged as two distinct approaches to medical image analysis. However, their relative expressive power remains largely unknown. Theoretically, hand-crafted radiomic features represent a mere subset of features that neural networks can approximate, thus making deep learning a more powerful approach. On the other hand, automated learning of hand-crafted features may require a prohibitively large number of training samples. Here we directly test the ability of convolutional neural networks (CNNs) to learn and predict the intensity, shape, and texture properties of tumors as defined by standardized radiomic features.MethodsConventional 2D and 3D CNN architectures with an increasing number of convolutional layers were trained to predict the values of 16 standardized radiomic features from real and synthetic PET images of tumors, and tested. In addition, several ImageNet-pretrained advanced networks were tested. A total of 4000 images were used for training, 500 for validation, and 500 for testing.ResultsFeatures quantifying size and intensity were predicted with high accuracy, while shape irregularity and heterogeneity features had very high prediction errors and generalized poorly. For example, mean normalized prediction error of tumor diameter with a 5-layer CNN was 4.23 ± 0.25, while the error for tumor sphericity was 15.64 ± 0.93. We additionally found that learning shape features required an order of magnitude more samples compared to intensity and size features.ConclusionsOur findings imply that CNNs trained to perform various image-based clinical tasks may generally under-utilize the shape and texture information that is more easily captured by radiomics. We speculate that to improve the CNN performance, shape and texture features can be computed explicitly and added as auxiliary variables to the networks, or supplied as synthetic inputs.
Effect of daily human movement on some characteristics of dengue dynamics
Authors: Tocto-Erazo Mayra R. , Olmos-Liceaga Daniel , Montoya-Laos Jose A. 
Published: September 2020

AbstractHuman movement is a key factor in infectious diseases spread such as dengue. Here, we explore a mathematical modeling approach based on a system of ordinary differential equations to study the effect of human movement on characteristics of dengue dynamics such as the existence of endemic equilibria, and the start, duration, and amplitude of the outbreak. The model considers that every day is divided into two periods: high-activity and low-activity. Periodic human movement between patches occurs in discrete times. Based on numerical simulations, we show unexpected scenarios such as the disease extinction in regions where the local basic reproductive number is greater than 1. In the same way, we obtain scenarios where outbreaks appear despite the fact that the local basic reproductive numbers in these regions are less than 1 and the outbreak size depends on the length of high-activity and low-activity periods.
Supporting decision-making on allocation of ICU beds and ventilators in pandemics
Authors: Cardona Magnolia , Dobler Claudia C. , Koreshe Eyza , Heyland Daren K , Nguyen Rebecca , Sim Joan P.Y. , Clark Justin , Psirides Alex 
Published: September 2020

AbstractAs the world struggles with the COVID-19 pandemic, health service demands have increased to a point where healthcare resources may prove inadequate to meet demand. Guidelines and tools on how to best allocate intensive care beds and ventilators developed during previous epidemics can assist clinicians and policy-makers to make consistent, objective and ethically sounds decisions about resource allocation when healthcare rationing is inevitable. This scoping review of 62 published guidelines, triage protocols, consensus statements and prognostic tools from crisis and non-crisis situations sought to identify a multiplicity of objective factors to inform healthcare rationing of critical care and ventilator care. It also took ethical considerations into account. Prognostic indicators and other decision tools presented here can be combined to create locally-relevant triage algorithms for clinical services and policy makers deciding about allocation of ICU beds and ventilators during a pandemic. Community awareness of the triage protocol is recommended to build trust and alleviate anxiety among the public. This review provides a unique resource and is intended as a discussion starter for clinical services and policy makers to consider formalising an objective triage consensus document that fits the local context.Take-home messageAn evidence-based catalogue of objective variables from 62 published resources tested in crisis and non-crisis situations can help clinicians make locally relevant triage decisions on ICU and ventilator allocation in inevitable COVID-19 health rationing.
Panbio antigen rapid test is reliable to diagnose SARS-CoV-2 infection in the first 7 days after the onset of symptoms
Authors: Linares Manuel , Pérez-Tanoira Ramón , Romanyk Juan , Pérez-García Felipe , Gómez-Herruz Peña , Arroyo Teresa , Cuadros Juan 
Published: September 2020

AbstractBackgroundReal-time reverse transcription polymerase chain reaction (RT-qPCR) is the current recommended laboratory method to diagnose SARS-CoV-2 acute infection, several factors such as requirement of special equipment, time consuming, high cost and skilled staff limit the use of these molecular techniques. A more rapid and high-throughput method is in growing demand.MethodsEvaluate the performances of the Panbio™ COVID-19 AG Rapid Test Device (Nasopharyngeal), a rapid immunochromatographic test for the detection of SARS-CoV-2 antigen, in comparison to RT-qPCR.ResultsThe RDT evaluated in this study showed a high sensitivity and specificity in samples mainly obtained during the first week of symptoms and with high viral loads.ConclusionsThis assay seems to be an effective strategy for controlling the COVID-19 pandemic for the rapid identification and isolation of SARS-CoV-2 infected patients.