bluuebunny/crossref_metadata_2025_split huggingface dataset:
Five-year changes of somatic risk factors and comorbidities in patients with angina of effort
Authors: Ugurchieva Р. О. , Didigova R. Т. , Khudyakov M. B. , Mamedov M. N. 
Published: March 2020

Aim. To assess five-year changes of somatic risk factors and comorbidities in patients with angina of effort.Material and methods. The study included 320 patients (143 men and 177 women aged 40-69 years) with coronary artery disease (CAD), class I-III angina of effort. Patients underwent examinations in 2012 in three medical centers of the Republic of Ingushetia (Russia), and in 2017 they were invited for a second complex examination with questionnaires, biochemical analysis, and instrumentation.Results. Over the five-year follow-up, there was an increase of men with class III effort angina up to 45%; a similar trend was observed in women. Both men and women experienced a three-fold increase in the incidence of type 2 diabetes. Initially and during the follow-up, chronic obstructive pulmonary disease was diagnosed 2 times more often in men than in women, which may be associated with smoking. A small increase in the total cholesterol level was recorded in the cohort; among women, these changes were significant. Target levels reach no more than 20% of patients. A significant increase of blood glucose levels over the 5-year period was observed in a cohort of men and women with effort angina.Conclusion. Over the 5-year follow-up, there was a clinical deterioration of the effort angina, which is associated with an increase in the incidence of some somatic diseases and the severity of the main behavioral and biological risk factors.
Cardiac strain in right ventricular myocardial infarction and pulmonary embolism
Authors: Mazur E. S. , Mazur V. V. , Rabinovich R. M. , Myasnikov K. S. , Orlov Yu. A. 
Published: March 2020

Aim. To study the prospects of using parameters of right ventricle (RV) longitudinal strain (LS) during systole for the differential diagnosis of RV myocardial infarction (RVMI) and pulmonary embolism (PE).Material and methods. The study included 83 patients who were hospitalized with RVMI or PE in the period from December 2017 to May 2019. The study of RV LS using the two-dimensional speckle-tracking echocardiography was carried out in 30 patients with RVMI (group 1), 15 patients with high-risk PE (group 2), and 38 patients with intermediate-risk PE (group 3).Results. The mean values of RV global LS in patients of groups 1 and 2 did not differ (12,8±2,69 and 12,0±2,56%, respectively) and were significantly lower than in patients of group 3 (15,9±3,03%). The ratio of the interventricular septum (IVS) LS to the RV free wall (FW) LS in the group 1 (1,04±0,43) was significantly lower than in the groups 2 (1,61±0,52) and 3 (1,29±0,38). The ratio of the LS of the RVFW basal segment to the apical segment in group 1 (0,60±0,37) was also significantly lower than in groups 2 (1,69±1,57) and 3 (1,67±1,33).Conclusion. In patients with RVMI, there is a comparable decrease in the LS of the RVFW and IVS, and the LS of the basal segment decreases to a greater extent than the apical one. In patients with PE, the decrease in the LS of the RVFW is more pronounced than in IVS, and the LS of the apical segment decreases to a greater extent than the basal one. These differences can be used for the differential diagnosis of RVMI and PE.
The MIMIC Study: Prognostic Role and Cutoff Definition of Monocyte-to-Lymphocyte Ratio and Lactate Dehydrogenase Levels in Metastatic Colorectal Cancer
Authors: Basile Debora , Garattini Silvio Ken , Corvaja Carla , Montico Marcella , Cortiula Francesco , Pelizzari Giacomo , Gerratana Lorenzo , Audisio Marco , Lisanti Camilla , Fanotto Valentina , Ongaro Elena , Iacono Donatella , Cardellino Giovanni Gerardo , Foltran Luisa , Pella Nicoletta , Buonadonna Angela , Aprile Giuseppe , Di Maio Massimo , Fasola Gianpiero , Puglisi Fabio 
Published: March 2020

Abstract

Background
Monocyte-to-lymphocyte ratio (MLR) and lactate dehydrogenase (LDH) levels are circulating biomarkers that provide information about tumor-related inflammation and immune suppression. This study aimed to evaluate the prognostic role of MLR and LDH in metastatic colorectal cancer (mCRC).

Material and Methods
This multicentric study analyzed a consecutive cohort of 528 patients with mCRC treated in 2009–2017. The whole population was randomly divided in training and validation cohort. The first was used to identify a threshold for MLR and to create the prognostic model with MLR and MLR-LDH combined (group 1: MLR-LDH low; group 2: MLR or LDH high; group 3: MLR-LDH high). The second cohort was used to validate the model.

Results
At the median follow-up of 55 months, median overall survival (OS) was 22 months. By multivariate analysis, high MLR &gt;0.49 (hazard ratio [HR], 2.37; 95% confidence interval [C.I.], 1.39–4.04), high LDH (HR, 1.73; 95% C.I., 1.03–2.90) in the first model, group 2 (HR, 2.74; 95% C.I.; 1.62–4.66), and group 3 (HR, 3.73; 95% C.I., 1.94–7.18) in the combined model, had a worse prognosis in terms of OS. These data were confirmed both in the validation set and then in the whole cohort.

Conclusion
MLR and LDH are circulating cost-effective biomarkers, readily available in clinical practice, that can be useful for predicting the prognosis of patients with mCRC.

Implications for Practice
High monocyte-to-lymphocyte ratio (MLR) and lactate dehydrogenase (LDH) levels could be a sign of a tumor's recruitment of suppressive and inflammatory cells worsening prognosis of different types of cancer, including colorectal cancer (CRC). Currently, no data are available for metastatic CRC regarding a cutoff definition for MLR or the prognostic impact of MLR and MLR-LDH combined. The present study showed in the training cohort and confirmed in the validation and whole cohort that MLR is a reliable and independent laboratory biomarker, which is easy to use, to predict clinical outcomes in patients with mCRC. Moreover, MLR and composite MLR-LDH could potentially result in an incremental improvement in the prognostic value of these biomarkers, being used as stratification tools for patients with mCRC.
Kidney Clearance of Secretory Solutes Is Associated with Progression of CKD: The CRIC Study
Authors: Chen Yan , Zelnick Leila R. , Wang Ke , Hoofnagle Andrew N. , Becker Jessica O. , Hsu Chi-yuan , Feldman Harold I. , Mehta Rupal C. , Lash James P. , Waikar Sushrut S. , Shafi Tariq , Seliger Stephen L. , Shlipak Michael G. , Rahman Mahboob , Kestenbaum Bryan R. ,   the CRIC Study Investigators
Published: March 2020

Significance Statement
The secretion of organic solutes by the proximal tubules is an essential intrinsic kidney function. However, the clinical significance of the kidney clearance of tubular secretory solutes is uncertain. In this prospective cohort study of 3416 participants with CKD, the authors found that lower kidney clearances of six endogenous secretory solutes are associated with significantly greater risk of CKD progression (defined as a ≥50% decline in eGFR from baseline, initiation of maintenance dialysis, or kidney transplantation) and that lower clearances of four solutes are associated with all-cause mortality after adjustment for eGFR, albuminuria, and other confounding characteristics. These findings suggest that kidney clearances of secretory solutes may provide complementary information to existing measurements of GFR and albuminuria for the assessment of kidney health.

Background
The secretion of organic solutes by the proximal tubules is an essential intrinsic kidney function. However, the clinical significance of the kidney’s clearance of tubular secretory solutes is uncertain.

Methods
In this prospective cohort study, we evaluated 3416 participants with CKD from the Chronic Renal Insufficiency Cohort (CRIC) study. We measured plasma and 24-hour urine concentrations of endogenous candidate secretory solutes at baseline, using targeted liquid chromatography–tandem mass spectrometry. The study defined CKD progression by a ≥50% decline in the eGFR, initiation of maintenance dialysis, or kidney transplantation. We used Cox proportional hazards regression to test associations of secretory-solute clearances with CKD progression and mortality, adjusting for eGFR, albuminuria, and other confounding characteristics.

Results
Participants in this ancillary study had a mean age of 58 years and 41% were black; the median eGFR was 43 ml/min per 1.73 m2. After adjustment, lower kidney clearances of six solutes—kynurenic acid, pyridoxic acid, indoxyl sulfate, xanthosine, isovalerylglycine, and cinnamoylglycine—were associated with significantly greater risks of CKD progression, with clearance of kynurenic acid, a highly protein-bound solute, having the strongest association. Lower clearances of isovalerylglycine, tiglylglycine, hippurate, and trimethyluric acid were significantly associated with all-cause mortality after adjustment.

Conclusions
We found lower kidney clearances of endogenous secretory solutes to be associated with CKD progression and all-cause mortality, independent of eGFR and albuminuria. This suggests that tubular clearance of secretory solutes provides additional information about kidney health beyond measurements of glomerular function alone.
LFA-1, MAC-1 LEUKOCITE INTEGRINS – TARGET FOR TUMOUR IMMUNITY MAGNIFICATION
Authors: Bocharova O. A. , Karpova R. V. , Bocharov E. V. , Vershinskaya A. A. , Baryshnikova M. A. , Kazeev I. V. , Soloviev Y. N. , Kucheryanu V. G. 
Published: March 2020

The aim of this investigation was to evaluate the expression of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) β2 integrins on blood cells in CBA mice in ontogenesis as well as under the dry extract of multifitoadaptogen administration during the first month of postnatal development.Materials and methods. The study was carried out on CBA male mice (CBA/LacY). The experimental mice received 0.3 % dry multiphytoadaptogene extract water-solution during the first month of life (preventive administration). Preparation was produced by a desiccation technology of forty medical herbs (including Panax ginseng, Eleutherococcus senticosus, Rhodiola rosea) water-ethanol extracts components. The CD11a and CD11b antigens expressions on peripheral blood cells were analyzed by indirect immunofluorescence reaction at the age of 4, 8, 22 months. Statistical analysis was performed with the program Statistica 6.0.Results. The development of genetically predisposed hepatocarcinomas in CBA male-mice was accompanied by a decrease in the expression of СD11a and CD11b antigens on blood cells. Dry multiphytoadaptogene extract administration during the first month of postnatal ontogenesis revealed the CD11a and CD11b antigens up-regulated expression. The effect of the dry multiphytoadaptogene extract is comparable to that for the liquid form of multifitoadaptogen previously identified.Conclusion. Up-regulated LFA-1 and Mac-1 β2 integrins expression on blood cells using dry multiphytoadaptogene extract administration during the first month of postnatal development is essential for enhance the contact interactions of immune effectors and cancer cells.The study was performed in accordance with ethical principles adopted by the European Convention for the protection of vertebrate animals used for experimental and other scientific purposes.
AGE-RELATED FEATURES OF SYSTEMIC ANTITUMOR IMMUNE RESPONSE IN PATIENTS WITH PRIMARY OPERABLE BREAST CANCER AND CANCER OF THE ORAL MUCOSA
Authors: Chertkova A. I. , Zabotina T. N. , Tsiklauri V. T. , Zakharova E. N. , Tabakov D. V. , Borunova A. A. , Shoua E. K. , Zaderenko I. A. , Vorotnikov I. K. , Mudunov A. M. , Kadagidze Z. G. 
Published: March 2020

Introduction.Age is considered as an important clinical and pathological factor in cancer patients. Malignant tumors are more likely to develop in older people, but the disease is less aggressive than in young patients. According to various authors, the influence of age on the development of tumors largely depends on the age-related features of the immune system.The aimof the present study was to determine the relationship of indicators of systemic antitumor immune response with the age of patients with primary operable breast cancer and cancer of the oral mucosa.Materials and methods.The study included patients with all subtypes of primary-operable breast cancer (n = 145) and patients with cancer of the oral mucosa (n = 29). Immunophenotyping of peripheral blood lymphocytes was performed using a wide panel of monoclonal antibodies to markers of adaptive and innate immunity cells.Results.In elder patients (40 years and older) with primary-operable breast cancer, the percentage of activated CD25+lymphocytes and CD4+CD25+and CD3+CD4+T cells, NKT cells, activated HLA-DR+ lymphocytes, including activated CD3+HLA-DR+T cells before treatment, was statistically significantly higher than in patients younger than 40 years. Patients of this group showed increase of CD8+CD - 11b+CD28–CTLs and a decrease in the number of naive lymphocytes (CD4 – CD62L+ and CD8+CD11b–CD28+) in comparison with control percentage, and the downward trend in CD4+CD25+CD127–Treg, with increased numbers of CD4+CD25+T cells. In patients with cancer of the oral mucosa, an increase in the number of cells of some populations of the immune effector link and a decrease in the number of suppressor lymphocytes were revealed with age.Conclusion.The results suggest that age-related differences in the state of systemic antitumor immune response contribute to a more favorable course of breast cancer and some other malignancies in older persons. It is obvious that the features of age differences in the immune response to the tumor should be taken into account when prescribing systemic therapy, including immunotherapy.All patients gave written informed consent to participate in the study
HOX GENE EXPRESSION IN HUMAN B-CELL PROGENITOR LEUKEMIA CELL LINES EXPRESSING E2A-PBX1 ONCOGENE
Authors: Shestakova E. A. 
Published: March 2020

Introduction. Acute lymphoblastic leukemia (ALL) is diagnosed mainly in children (2/3 of diseases) making this type of leukemia one of the most common oncological diseases among children. Oncogenes are involved in the development of ALL, in particular the product of chromosomes 1 and 19 translocation, the oncogene E2A-PBX1 that codes for E2A-PBX1 chimeric oncoprotein with strong transcription activation properties as well as oncogenes of HOX family, mainly HOXA and HOXB cluster genes. E2A-PBX1 chimeric oncoprotein and НОХА proteins are associated in vivo with factors participating in epigenetic regulation of gene expression such as chromatin modifying and remodeling enzymes that partially determines their oncogenic properties. In previous studies we obtained data indicating genetic interactions of E2A-PBX1 and НОХ genes participating in leukemia development.The aim of this research was to confirm the role of Е2А – РВХ1 oncogene in the activation of the expression of НОХА cluster genes coding for the proteins with high oncogenic potential.Materials and methods. The objects of the study were four B cell progenitor (pre-B) leukemia cell lines: RCH-ACV, KASUMI-2, 697 and NALM-6. Standard polymerase chain reaction (PCR) was used for the identification of chromosome 1 and 19 translocation product, E2A-PBX1 oncogene and its expression. Method of reverse transcription coupled with quantitative polymerase chain reaction (Q-RT-PCR) was used for the analysis of 11 HOXA cluster genes expression.Results. It is demonstrated that E2A-PBX1 oncogene is present and expressed in three studied human pre-B leukemia cell lines, RCH-ACV, KASUMI-2 and 697, while its expression is absent in NALM-6 cell line. High expression of 7 from 11 HOXА cluster genes is revealed in RCH-ACV, KASUMI-2 and 697 cell lines expressing E2A-PBX1 oncogene, whereas NALM-6 cell line, that does not express E2A-PBX1 oncogene, also does not express HOXA genes except low expression of two genes from this cluster.Conclusions. The data obtained in this study demonstrate that RCH-ACV, KASUMI-2 and 697 human leukemia pre-B cell lines, containing and expressing Е2А-РВХ1 oncogene, also express most of HOXA genes (7 genes of 11 genes) at high level in contrast to control NALM-6 cell line that does not comprise Е2А-РВХ1 oncogene and almost does not express НОХА genes. Therefore, the results of this study suggest the participation of strong transcriptional activator, chimeric oncoprotein Е2А-РВХ1, associated with chromatin modifying and remodeling enzymes, in the expression activation of HOXA cluster genes that also possess high oncogenic potential.
Comparative study of laparoscopic and open surgery in management of 50 cases of liver hydatid cyst
Authors: Gohil Vikram B. , Thakur Swarnim U. , Mehta Smit M. , Dekhaiya Firdaus A. 
Published: March 2020

Background: Echinococcosis is caused by parasite called Echinococcus granulosus and Echinococcus multilocularis. The modern treatment of hydatid cyst of the liver varies from surgical intervention to percutaneous drainage or medical therapy.Methods: This clinical study was done on 50 patients who had liver hydatid disease admitted in Sir T Hospital, Bhavnagar from August 2013 to February 2016. Patients were divided into two groups consisting of 25 cases in each. Group A: managed by open surgery. Group B: managed by laparoscopic surgery. All patients followed up for 6 months after surgery.Results: The mean operative time in Group A was 65.2 minutes (range 35-100 minutes) while in Group B it was 76.32 minutes (range 50-100 minutes). Group B patients were mobilised early and resumed duty very fast then Group A. The mean duration of stay in hospital was 12.4 days (range 4-20 days) in Group A and 6.2 days (range 4-12 days) in Group B. Wound infection seen in 16% in Group A and 0% in Group B. General complication rate was 32% in Group A and 8% in Group B. No recurrence noticed in either group during follow up.Conclusions: Overall laparoscopic management of liver hydatid cyst is cost effective in terms of early mobilization, early discharge and early resumption of work along with cosmetic benefit.
Trabalho e saúde mental: a relação existente no cenário do CAPS Maria Boneca de Uberaba-MG
Authors: Aguiar Daniella Amaral 
Published: March 2020

RESUMOA presente pesquisa trás uma análise acerca de como a categoria trabalho se apresenta à área da saúde mental brasileira, expressa em um Centro de Atenção Psicossocial da cidade de Uberaba-MG. Através da participação de usuários dos serviços e de profissionais da área do Serviço Social e Terapia Ocupacional traçou-se um apanhado dos limites e das possibilidades que permeiam à saúde mental através de novas estratégias intervir de forma a fortalecer a (re) inserção e (re) socialização de pessoas em condição de sofrimento psíquico na dinâmica de uma sociedade capitalista, entendendo a percepção individual de usuários e abrangendo o papel do Estado, enquanto provedor e regulador de políticas sociais. ABSTRACTThis research back an analysis on how the work category is presented to the area of the Brazilian mental health, expressed in a Psychosocial Care Center in the city of Uberaba-MG. Through the participation of service users and professionals in the field of Social Work and Occupational Therapy drew up an overview of the limits and possibilities that permeate the mental health through new strategies intervene to strengthen the (re) integration and (re ) socialization of people in psychological distress condition in the dynamic of a capitalist society, understanding the individual's perception of users and covering the state's role as provider and regulator of social policies. RESUMENEsta investigación de vuelta un análisis sobre cómo la categoría de trabajo se presenta a la zona de la salud mental de Brasil, expresaron en un Centro de Atención Psicosocial en la ciudad de Uberaba-MG. A través de la participación de los usuarios de los servicios y los profesionales en el campo del Trabajo Social y Terapia Ocupacional elaboró un resumen de los límites y las posibilidades que impregnan la salud mental a través de nuevas estrategias de intervención para fortalecer la (re) integración y (re ) la socialización de las personas en condición de malestar psicológico en la dinámica de una sociedad capitalista, la comprensión de la percepción del individuo de los usuarios y que cubre el papel del Estado como proveedor y regulador de las políticas sociales.
Quantification of the morphology of gold grains in 3D using X-ray microscopy and SEM photogrammetry
Authors: Masson François-Xavier , Beaudoin Georges , Laurendeau Denis 
Published: March 2020

ABSTRACTThe shape of gold is widely used in mineral exploration and in sedimentology to estimate the distance of transport from the source to the site of deposition. However, estimation of the morphology is based on qualitative observations or on the quantification of shape in 2D. The 3D analysis of grain shape is useful for accurate morphometric quantification and to evaluate its volume, which is related to particle size. This study compares X-ray 3D microscope and 3D SEM photogrammetry to reconstruct the shape of gold particles. These new methods are exploited to quantify the shape of gold grains 85 to 300 μm in size. The shape parameters, such as axial lengths, surface area, volume, diameter of curvature of all corners, and diameter of the largest inscribed sphere and smallest circumscribed sphere are measured on a particle in order to estimate shape factors such as flatness ratios, shape indices, sphericity, and roundness. Most shape parameters and shape factors estimated on the same gold grain with simple geometry are similar between the two approaches. This result validates these methods for the 3D description of gold particles with simple morphology, while providing a methodology for describing grains with more complex geometry.
Le magmatisme neogene betico-rifain et le couloir de decrochement trans-Alboran
Authors: Hernandez Jean , de Larouziere Francois Dominique , Bolze Jean , Bordet Pierre 
Published: March 2020

Abstract
The Miocene basin evolution of southeastern Spain and eastern Morocco is linked to a "shear zone" elongated from SW across the Alboran Sea. In Spain the magmatism is mostly calc-alkaline (or K-rich calc-alkaline). Most of the products are locatred on strike-slip faults (Almeria-Cabo de Gata). Lavas of dacitic compositions are interpreted as products of crustal anatexis. During Messinian time, lamproites are erupted over an extended area. Later (Plio-Quaternary), alkali basalts are located near Cartagena. In Morocco, calc-alkaline magmatism is not as developed as in Spain; late Tortonian-Messinian volcanoes (Gourougou, Guilliz) have erupted of shoshonitic lavas. Alkali basalts are abundant and appear from the end of Messinian to Quaternary all over northwestern Africa. In the studied area, there are no chronological nor geochemical polarity of the magmatism according to the existence of a Miocene subduction. The association of the magmatism with tectonics and basin evolution shows that it is linked with their aperture. The structure of the lithosphere, as it appears from the geophysical data, shows the existence of two different crusts, separated by the western part of the "shear zone". Trans-Alboran calc-alkaline magmatism is clearly correlated with the activity of this "shear zone", from Miocene to present time.
Contribution a la connaissance de la faune de l'oolithe ferrugineuse oxfordienne de Talant, Cote-d'Or
Authors: Maire Victor 
Published: March 2020

Abstract
Lists the fauna from the Oxfordian (Jurassic) ferruginous oolite of Talant, Cote-d'Or, France. Most of the fossils were not found in place, but are grouped according to zones on the basis of comparison with known faunas of the various Oxfordian horizons.