bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structure and Evolution of Constitutive Bacterial Promoters
Authors: Lagator Mato , Sarikas Srdjan , Steinrück Magdalena , Toledo-Aparicio David , Bollback Jonathan P. , Tkacik Gasper , Guet Calin C. 
Published: May 2020

AbstractPredicting gene expression levels from any DNA sequence is a major challenge in biology. Using libraries with >25,000 random mutants, we developed a biophysical model that accounts for major features of σ70-binding bacterial promoters to accurately predict constitutive gene expression levels of any sequence. We experimentally and theoretically estimated that 10-20% of random sequences lead to expression and 82% of non-expressing sequences are one point mutation away from a functional promoter. Generating expression from random sequences is pervasive, such that selection acts against σ70-RNA polymerase binding sites even within inter-genic, promoter-containing regions. The pervasiveness of σ70– binding sites, which arises from the structural features of promoters captured by our biophysical model, implies that their emergence is unlikely the limiting step in gene regulatory evolution.
The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment
Authors: Shi Xiaoshan , Chang Chunmei , Yokom Adam L. , Hurley James H. 
Published: May 2020

AbstractThe selective autophagy pathways of xenophagy and mitophagy are initiated when the adaptor NDP52 recruits the ULK1 complex to autophagic cargo. Hydrogen-deuterium exchange coupled to mass spectrometry (HDX-MS) was used to map the membrane and NDP52 binding sites of the ULK1 complex to unique regions of the coiled coil of the FIP200 subunit. Electron microscopy of the full-length ULK1 complex shows that the FIP200 coiled coil projects away from the crescent-shaped FIP200 N-terminal domain dimer. NDP52 allosterically stimulates membrane-binding by FIP200 and the ULK1 complex by promoting a more dynamic conformation of the membrane-binding portion of the FIP200 coiled coil. Giant unilamellar vesicle (GUV) reconstitution confirmed that membrane recruitment by the ULK1 complex is triggered by NDP52 engagement. These data reveal how the allosteric linkage between NDP52 and the ULK1 complex could drive the first membrane recruitment event of phagophore biogenesis in xenophagy and mitophagy.
Transient intestinal colonization by a live-attenuated oral cholera vaccine induces protective immune responses in streptomycin-treated mice
Authors: Fakoya Bolutife , Sit Brandon , Waldor Matthew K. 
Published: May 2020

AbstractCurrent mouse models for evaluating the efficacy of live oral cholera vaccines (OCVs) have important limitations. Conventionally raised adult mice are resistant to intestinal colonization byVibrio cholerae,but germ-free mice can be colonized and have been used to study OCV immunogenicity. However, germ free animals have impaired immune systems and intestinal physiology; also, live OCVs colonize germ free mice for many months, which does not mimic the clearance kinetics of live OCVs in humans. Here, we leverage antibiotic-treated, conventionally raised adult mice to study the effects of transient intestinal colonization by a live OCVV. choleraestrain. In a single dose vaccination regimen, we found that HaitiV, a live-attenuated OCV candidate, was cleared by streptomycin treated adult mice within a week after oral inoculation. This transient colonization elicited far stronger adaptive immune correlates of protection against cholera than did inactivated whole-cell HaitiV. Infant mice from HaitiV vaccinated dams were also significantly protected from choleric disease than pups from inactivated-HaitiV dams. Our findings establish the benefits of antibiotic treated mice for live OCV studies as well as its limitations and underscore the immunogenicity of HaitiV.ImportanceOral cholera vaccines (OCVs) are being deployed to combat cholera but current killed OCVs require multiple doses and show little efficacy in young children. Live OCVs have the potential to overcome these limitations but small animal models for testing OCVs have shortcomings. We used an antibiotic treatment protocol for conventional adult mice to study the effects of short-term colonization by a single dose of HaitiV, a live OCV candidate. Vaccinated mice developed vibriocidal antibodies againstV. choleraeand delivered pups that were resistant to cholera, whereas mice vaccinated with inactivated HaitiV did not. These findings demonstrate HaitiV’s immunogenicity and suggest that this antibiotic treatment protocol will be useful for evaluating the efficacy of live OCVs.
Electronic stabilization by occupational disorder in the ternary bismuthide Li3–x–y
In
x
Bi (x ≃ 0.14, y ≃ 0.29)
Authors: Ovchinnikov Alexander , Bobev Svilen 
Published: May 2020

A ternary derivative of Li3Bi with the composition Li3–x–y
In
x
Bi (x ≃ 0.14, y ≃ 0.29) was produced by a mixed In+Bi flux approach. The crystal structure adopts the space group Fd\overline{3}m (No. 227), with a = 13.337 (4) Å, and can be viewed as a 2 × 2 × 2 superstructure of the parent Li3Bi phase, resulting from a partial ordering of Li and In in the tetrahedral voids of the Bi fcc packing. In addition to the Li/In substitutional disorder, partial occupation of some Li sites is observed. The Li deficiency develops to reduce the total electron count in the system, counteracting thereby the electron doping introduced by the In substitution. First-principles calculations confirm the electronic rationale of the observed disorder.
Uncertainty representation and information measurement of grey numbers
Authors: Chen Nanlei , Xie Naiming 
Published: May 2020

PurposeThe purpose of this paper is to propose an uncertainty representation and information measurement method for characterizing grey numbers, estimating their internal laws and solving how to generate them based on available information data in the real world.Design/methodology/approachThis paper attempts to present a new mathematical methodology in the field of grey numbers. The generalized grey number is defined at first with the concept of information elements and information samples. Then, the probability function of a grey number is proposed to describe the internal law of the grey number. By finding the feasible information elements from information samples, the probability calculation method for the true value of a grey number is presented. Finally, some numerical examples and comparisons are carried out to assess the efficiency and performance.FindingsThe results show that the uncertainty representation and information measurement method is effective in characterizing and quantifying grey numbers based on available information data.Practical implicationsUncertain information is widespread in practical applications. In this manuscript, the grey number is represented and its information is measured through some existing data in discrete or interval forms, which provides a grey information concept that utilizes information elements to represent uncertainty in the real world.Originality/valueThe proposal presents a novel data-driven method to generate a grey number representation from available data rather than the classical whitening weight function constructed from experience, and the dynamic evolution process of a grey number is measured by the increase of information samples.
Measuring corporate social responsibility in Islamic banking: what matters?
Authors: Zafar Muhammad Bilal , Sulaiman Ahmad Azam 
Published: May 2020

PurposeThis paper begins with a challenge to explore the scope and dimensions of corporate social responsibility (CSR) in Islamic banking and design a CSR disclosure index, which may gauge the level of CSR disclosure in Islamic banking.Design/methodology/approachIt adopts a two-fold approach to develop the CSR disclosure index for Islamic banking, such as “identification” and “prioritization.” In the ambit of identification, it relies on the existing literature related to CSR and Islamic banking. However, it undertakes analytical hierarchy process (AHP) method for prioritization through the sample of 104 experts related to Islamic banking of Pakistan.FindingsIt concludes the CSR index for Islamic banking contains five dimensions, including 79 items across 20 sub-dimensions. The results of AHP indicate that the CSR dimensions are important forShariahgovernance, employee, community, customer and environment. Moreover, within dimensions, the most important sub-dimensions areShariahcompliance, customer service and quality, green investing/banking, customer relationship, training and development and poverty alleviation.Practical implicationsThe CSR disclosure index of this study has important implications for academicians, such as it paves the ways for further investigations and practical usage of index to gauge the level CSR disclosure of Islamic banking. Moreover, it delineates the spectrum of responsibilities for managers of Islamic banking under the domain of CSR.Originality/valueThe proposed CSR disclosure index is comprehensive and stresses on the social responsibility of Islamic banking toward stakeholders. In nutshell, this study offers what is expected from the practitioners of Islamic banking in the domain of social responsibility.
Be close or stay away: the interactive effect of loneliness and information frameworks on consumer's anthropomorphic product preference
Authors: Li Shihao , Zhang Hongxia , Wang Xuefang , Fu Guoqun 
Published: May 2020

PurposeThis article investigated the relationship between loneliness and anthropomorphic products.Design/methodology/approachThe authors conducted three studies to examine their hypotheses.FindingsThe authors confirmed that highly lonely people would like to seek for social relationship. What's more, they may try to compensate by creating a sense of connection with nonhuman products so they will prefer anthropomorphic products. Further, the authors demonstrated that information framework can moderate this effect. Highly lonely consumers would increase their preference to anthropomorphic product under promotion-focus information, whereas they would decrease their preference to anthropomorphic product under prevention-focus information. These effects do not exist in lowly lonely consumers. At the same time, the authors demonstrate that the effect is mediated by perceived social connection.Originality/valueThis article contributes to loneliness literature in the consumer behavior field and proves the moderation effect of the information framework, which can deepen our understanding of the relationship between loneliness and anthropomorphic products.
Labor demographics and productivity: all-star roster turnover and foreigners
Authors: Schmidt Martin B. 
Published: May 2020

PurposeTalent compression is the labor market phenomenon where the average productivity differential between participants declines and has been used to explain the overall increase in competition within some professional sports markets. A finding that competitiveness is uniquely driven by talent compression is consistent with Rottenberg (1956), who argued that resource distribution is independent of factors that are invariant to labor productivity.Design/methodology/approachRather than incorporate MLB team roster turnover as many of the past studies have done, we prefer to measure of all-star turnover in membership. Problematically, movement from an MLB team to an MLB team is limited by rule, finances and the fact that there are very few teams competing for player services. In contrast, All-Star membership is typically costlessly chosen by many millions of fans, league players and managers. In this way, All-Star voting should be invariant to many of the factors that affect movement from an MLB team to an MLB team.FindingsIn the end, we find that a close association between all-star turnover rates and the makeup of MLB’s labor pool.Originality/valueThe paper offers a new measure of player mobility.
De-escalation strategies for kleptocracy in Nigeria’s oil sector
Authors: Das Vasudev 
Published: May 2020

Purpose
The purpose of this qualitative case study is to explore strategies for the de-escalation of kleptocracy in Nigeria’s oil and gas industry.

Design/methodology/approach
The author used a qualitative case study to facilitate the generation of data from eight research participants in semi-structured open-ended interviews.

Findings
The themes that emerged from analysis of interview transcriptions were high self-control, traditional African oath of office, whistleblowing, stiffer penalties for corrupt officials, education and training, self-regulation and sonic therapeutic intervention.

Research limitations/implications
Interviewees might withhold information regarding their insights on strategies for de-escalating kleptocracy. That was beyond my control.

Practical implications
The study results provided leaders with insightful comprehension of anti-kleptocracy policy in the oil and gas industry. Therefore, leaders would benefit and advance their decision-making process on the development and implementation of an anti-kleptocracy strategy to revamp the financial value of the oil and gas industry in Nigeria.

Social implications
The results of the study have the potential to contribute to positive social change by enlightening government leaders and anti-corruption agencies on strategies to de-escalate kleptocracy in the oil and gas industry.

Originality/value
The study’s uniqueness enabled filling the gap in financial crime literature as well as an added value to the applied management and decision sciences domain.
How prepared are Myanmar's health care professionals in their response to gender-based violence?
Authors: Ei Aye Nyein , Chuemchit Montakarn 
Published: May 2020

PurposeGender-based violence (GBV) has negative impact on the health and well-being of the survivors. The initial response can lessen the magnitude of the effect, and thus the health care sector's readiness to respond to GBV cases is important. This study aimed to explore the knowledge, attitude and its association to practice regarding GBV response among health care personnel.Design/methodology/approachA cross-sectional study was conducted in 48 public hospitals in Yangon, Myanmar, involving 398 participants including doctors and nurses, by a self-administered structured questionnaire.FindingsAmong 398 participants, most of the participants had moderate level of knowledge, attitude and supportive environmental factors. Only 12.8% had experienced GBV management. The respondents with a bachelor's degree were more likely to practice on health care management towards GBV cases than those who finished with a diploma degree. The medical officers and senior medical officers were more likely to practice than the junior nurses. The participants who had already attended the trainings had more practice than those who had not. Those who work in the regional hospitals were less likely to practice than those who work in the station-level hospital.Originality/valueThis paper explored the associated factors to health care personnel's practice of health care management towards GBV survivors in Myanmar which contains information about knowledge, attitude and supportive environmental factors. The study results can be used for a supportive data for health system strengthening the response of GBV cases in Myanmar.
Deep-level diversity and workgroup creativity: the role of creativity climate
Authors: Tripathi Nachiketa , Ghosh Vinit 
Published: May 2020

PurposeThis paper aims to explore the effect of perceived “self-to-team” deep-level diversity on team’s creative output from a social identity lens’ view.Design/methodology/approachAn experimental study was designed (n= 30 in each experimental condition, namely, homogeneous, heterogeneous and mixed) and vignettes were used to manipulate the experimental conditions. Employees from four Indian organizations participated in the experimental study.FindingsResults indicated that deep-level homogeneous group perceived higher team creative output as compared to the deep-level heterogeneous group. Perceived team creativity climate was found to mediate the effect of team diversity on team’s creative output. Further, it was observed that the quality of perceived creativity climate (positive and negative) moderated the relationship between diversity and team’s creative output.Practical implicationsThe diversity–climate–creativity model presented in the paper may help managers to understand how “deep-level” group composition affects a group’s creative performance. The findings of this study may act as a platform for building effective diversity management policies.Originality/valueThe current research has contributed to the limited team diversity and creativity literature. Based on the experimental study, the paper has uniquely investigated team diversity and creativity link along with examining the role of a mediator (creativity climate) and moderator (quality climate) in the relationship. As the study was conducted in Indian settings, the findings were interpreted based on the typical Indian psycho-social characteristics.
The future of health tourism in the industrial revolution 4.0 era
Authors: Wong Brian Kee Mun , Sa’aid Hazley Sarah Alia 
Published: May 2020

Purpose
The technological advances in the Industrial Revolution (IR) 4.0 era escalate the advancement of the healthcare industry, including the health tourism phenomenon. Based on the current trend in connected health care (e.g. mobile healthcare technology; digital health, etc.), this paper aims to propose that the distance between healthcare providers around the globe and its potential patients can be vastly reduced to almost on a real time basis.

Design/methodology/approach
A secondary literature review is conducted to identify the key development of IR 4.0 technologies in the healthcare industry and its possible trend leading the health tourism sector.

Findings
The adoption of IR 4.0 technologies is expected to make seeking treatments overseas more affordable, accessible and health records readily available on a real-time and secured basis. However, it is worth to note that the growth of health tourism raises the eyebrows of society from the security, social and economic perspectives.

Originality/value
This paper contributes to our understanding that the emergence of IR 4.0 technologies changes the landscape of the health care and health tourism industry. Continuous technology advancement is expected to further shape the future trend and escalate the commercialization aspect of the health tourism industry.
Prevalence of depression and associated factors among hemodialyzed patients in Jazan area, Saudi Arabia: a cross-sectional study
Authors: Othayq Asim , Aqeeli Abdulwahab 
Published: May 2020

PurposeThis study aims to evaluate the prevalence of depression and associated risk factors among patients on hemodialysis in Jazan area, Saudi Arabia.Design/methodology/approachThe study was conducted on 211 randomly selected hemodialysis patients in Jazan area, Saudi Arabia, using an observational cross-sectional design. Patients were screened for depressive symptoms using the depression, anxiety and stress scale 42 (DASS-42). Descriptive statistics were used to present sociodemographic data. Multiple logistic regression was implemented to identify the predictors of depression. Data were entered and analyzed using SPSS 22.0 software.FindingsThe study found the overall prevalence of depression among patients on hemodialysis to be 43.6 per cent. Of them, 12.8 per cent were mildly depressed, 15.6 per cent were moderately depressed and 15.1 per cent fell in the severe or extremely severe category. Depression was significantly associated with marital status, education level and the presence of sleep disturbances. The study indicates a high prevalence of depressive symptoms among patients on hemodialysis in Jazan. A higher rate of depressive symptoms was observed in currently unmarried, lower-educated patients and those with sleep disturbance.Originality/valuePeriodic evaluation of patients on hemodialysis for depression is needed to allow for early intervention.
Effect of the multiple projectile on the low-velocity impact response of CNTs reinforced beam
Authors: Qanber Ali Sadik Gafer , Alhusseini Raed Salman Saeed , Al-Kasob Bashar Dheyaa Hussein , Jasim Manar Hamid , Ranjbar Mehdi 
Published: May 2020

PurposeThe main objective of this article is to develop a theoretical formulation for predicting the response of CNTs reinforced beam under multiple impactors with general boundary conditions, using first-order shear deformation beam theory.Design/methodology/approachThe rule of mixtures is implemented to derive the material properties of the beam. The nonlinear Hertz contact law is applied for simulation between impactors and the surface of the beam. A combination of approaches includes energy method, Ritz method and generalized Lagrange equations are used to extract the matrix form of equations of motion. The time-domain solution is obtained using implementing the well-known Runge Kutta 4th order method.FindingsAfter examining the accuracy of the present method, the effects of the number of impactors include one impactor, and three impactors in various CNTs volume fraction are studied for CNTs reinforced beam with clamped-clamped, clamped-free and simply supported boundary conditions under the low-velocity impact. The most important finding of this article is that contact force and beam indentation at the middle of the beam in the case of one impactor are greater than those reported in the case of three impactors.Originality/valueThis article fulfills an identified need to study how CNTs reinforced beam behaviour with general boundary conditions under multiple low-velocity impacts can be enabled.
Measuring the influence of hospitality organizational climate on employee turnover tendency
Authors: Datta Amit 
Published: May 2020

PurposeThis study aims to identify the underlying dimensions of hospitality organizational climate and then measure the influence of it on employee turnover tendency.Design/methodology/approachData were obtained from 504 employees across 18 upscale hotels in India. Factor analysis was adopted to identify the organizational climate dimensions and its influence on turnover tendency was measured by SEM. One-way ANOVA tested the hypothesis related to the perceived differences among the employees regarding turnover intention.FindingsResult supports the hypothesized relationship between the constructs that the identified organizational climate structure have strong inverse relationship with employee turnover tendency and its dimension “leaders facilitation and support” was found to influence turnover intention the most, followed by “cohesion, clarity and objectivity of system,” “esprit of profession, organization and workgroup” and “job challenge, variety and feedback.” Results also determined differences among the hotel employees of different job levels and gender regarding turnover tendency.Practical implicationsStudy reveals that employee turnover tendency is predominantly influenced by the identified factors of organizational climate and more among the male frontline employees and attrition reduces with age and position. This knowledge will help the hotel's management in designing strategic HRM to control attrition.Originality/valueThis study is the first to establish an organizational climate measure of hotel industry in India and opens scope for future research. It also draws attention to the relationship of organizational climate with turnover tendency.