bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wnt/β-catenin Inhibitor ICG-001 Enhances the Antitumor Efficacy of Radiotherapy by Increasing Radiation-induced DNA Damage and Improving Tumor Immune Microenvironment in Hepatocellular Carcinoma
Authors: Huang Yan , Sheng Hailong , Xiao Yazhi , Zhang Zhihong , Chen Yiyao , Zhu Zhenru , Cao Chuanhui , Sun Jingyuan 
Published: August 2020

Abstract
Background: Radiotherapy has a promising anti-tumor effect in hepatocellular carcinoma (HCC), depending on the its regulatory effects on both cancer cells and tumor immune microenvironment (TME). Wnt/β-catenin signaling pathway activation, which is one of the most common alterations in HCC patients, has been reported to induce radioresistance, and also create immunosuppressive TME. However, it is unclear whether inhibition of wnt/β-catenin pathway could enhance the treatment efficacy of radiotherapy. In this study, we aim to explore the effect of wnt/β-catenin inhibitor ICG-001 in combination with radiotherapy and the underlying mechanism in HCC.Methods: C57BL/6 and nude mouse subcutaneous tumor models were used to evaluate the efficacy of different treatment regimens in tumor growth control, tumor recurrence inhibition and survival improvement. Flow cytometry was performed to assess the alterations of tumor infiltrating lymphocytes (TILs). Radioresistance was investigated by clone formation assay and γ-H2AX measurements. Wnt/β-catenin and cGAS/STING pathway activation was detected by immunoblotting. Results: The addition of ICG-001 to radiotherapy exhibited better anti-tumor control efficacy in tumor-bearing C57BL/6 mice than nude mice, which suggested that ICG-001 had a critical role in activating TME. The comprehensive analysis of TILs revealed that compared with radiotherapy alone, the combination of ICG-001 with radiotherapy boosted the infiltration and IFN-γ production ability of TIL CD8+ T cells, meanwhile reduced the number of TIL Tregs. Moreover, mechanism study demonstrated that ICG-001 exerted a radiosensitizing effect on HCC cells, thus leading to stronger activation of cGAS/STING signaling pathway upon radiotherapy in vitro and in vivo. Utilization of STING inhibitor, C-176, significantly impaired the synergetic effect of ICG-001 with radiotherapy on tumor control and TME activation. Furthermore, combination therapy led to a stronger immunologic memory and lasting anti-tumor immunity than radiotherapy, thus preventing tumor relapse in HCC tumor-bearing mice.Conclusion: Our findings showed that ICG-001 increased radioresistance and improved TME upon radiotherapy in HCC. Compared with radiotherapy alone, the combination of ICG-001 with radiotherapy displayed better therapeutic efficacy in inhibiting tumor growth, prolonging survival, and preventing recurrence in tumor-bearing mice. These data indicated that ICG-001 might be a potential synergetic treatment for radiotherapy and radioimmunotherapy in HCC.
A Joint Optimization Scheme of Resource Allocation in Downlink NOMA with Statistical Channel State Information
Authors: Xu Lei , Yao Jing Yi , Cai Jing , Fang Yu Hong , Li Hui Xiao 
Published: August 2020

Abstract
In a real communication scenario, it is very difficult to obtain the real-time Channel State Information(CSI) accurately, so the communication systems with statistical CSI have been researched. In order to maximize the throughput of the downlink Non-Orthogonal Multiple Access (NOMA) system with statistical CSI, the formula of system throughput is derived at first. Then, according to the combinatorial characteristics of the original optimization problem, it is divided into two subproblems, that is user grouping and power allocation. At last, a joint optimization scheme is proposed. In which, Genetic algorithm is introduced to solve the subproblem of power allocation, and Hungarian algorithm is introduced to solve the subproblem of user grouping. By comparing the ergodic date rate of NOMA users with statistical CSI and perfect CSI, the effectiveness of the statistical CSI sorting is verified. Compared with the Orthogonal Multiple Access (OMA) scheme, the NOMA scheme with the fixed user grouping scheme and the random user grouping scheme, the proposed scheme can effectively improve the system throughput.
Burden of Aflatoxin in Poultry Feeds in Selected Chicken Rearing Villages of Bishoftu-ethiopia
Authors: Megerssa Yoseph Cherinet , Kassaw Tadesse Sisay , Woldemariyam Fanos Tadesse 
Published: August 2020

Abstract
Background: Aflatoxins are major contaminants of feed used in poultry industry that negatively affect animal and human health. In Ethiopia, previous studies on aflatoxins mainly considered cattle feed and milk, but scarce information exists for poultry feeds.Method: The aim of this study was to determine the burden of aflatoxin in poultry feed in bishoftu.Cross sectional study was conducted from December, 2018 to May, 2019and 33 compound poultry feed samples were randomly collected from chicken rearing villages of Bishoftuand analyzed for G2, G1, B2 , B1 and total aflatoxins using HPLC.Results: The result indicated thatfrom a total of 33 samples 31(94%) samples were contaminated with aflatoxin. The mean level of aflatoxin G2, G1, B2, B1 and total aflatoxinswere 18.00 µg/g, 88.5499 µg/g, 13.50µg/g, 70.11µg/g and 190.18µg/g respectively. This study curtained the level of aflatoxinin 25 (72.75%) samples for AFT and 22 (66.67%) samples for AFB1 were above the limit of FDA regulatory levels of 20µg/g for poultry feed. Conclusion: The study showed the high contamination of aflatoxins in poultry feed. The study warrants the need for preventive strategies of aflatoxin contamination including implementation of regulatory legislation in poultry feeds in Bishoftu.
Single Pick Cutting Rock Load Identification Based on Improved Regularization Method
Authors: Dong Lei , Zhai Siyu , Wang Bukang , Dong Liang , Wang Junyuan , Shi Ruimin 
Published: August 2020

Abstract
To explore the relationship between the cutting vibration and the cutting load of a single pick, this paper studied a new method for a single pick cutting rock load identification. This paper improved the low accuracy problem of the regularization method in the inverse process of frequency response function in the traditional load identification method by introducing a filter operator. By combining the inverse pseudo excitation method and the improved regularization method, the identification of the load dependent on the vibration signal was realized. A single pick cutting rock test equipment was built, which could simulate the actual working conditions of pick cutting rock in underground or tunnel. By changing cutting speed, cutting angle, cutting line spacing and cutting depth of the single pick, the change trends of real cutting load and identification load were obtained. The load identification method proposed in this paper was consistent with the change trend of the real load under the single pick cutting state. Therefore, the method had good recognition accuracy and the maximum load recognition error was 17.35%. Compared with the traditional load identification method, the identification error was reduced by a maximum of 1.98%. This method can identify the cutting load of single pick and modify the morbidity problem of frequency response function matrix. The method has a better recognition effect on the cutting load of the pick than the traditional recognition method. The research could benefit for the design of the cutting system and the arrangement of the pick on the coal mine or tunneling machinery.
Lymphocyte May Be a Reference Index of the Outcome of Cancer Patients in COVID-19 Infection
Authors: Yuan Xun , Gao Yuan , Chu Qian 
Published: August 2020

Abstract
Background: The novel coronavirus (COVID-19)–infected pneumonia is an international concern as it spreads through human populations and across national and international borders.Methods: In this retrospective study, we consecutively included all cancer cases who had been identified as having a nucleic acid-confirmed COVID-19 infection from two designated hospitals in Wuhan, China. Non-cancer patients were also enrolled for comparison. The clinical data were gathered from the medical recordsfrom Jan 14 to March 12.Results: Among the 117 cancer patients infected with COVID19, the median age was 63 years and 48.7% were male. Male, hematologic cancer, dyspnea on admission, and anti-cancer therapy significantly increased the risk of death. The amounts of cytokines and immune cells were correlated with the outcomeofcancer patients infected with COVIP-19. However, high level of TNF-a, IL-2R, IL-6, IL-8 did not increase the risk of death in non-cancer patients. Moreover, IL-2R and IL-6 markedly decreased in cancer patients recovered from COVID-19.Conclusions: Cancer patients with COVID-19 were associated with high mortality (23.9%).The amounts of cytokines and lymphocytes could be utilized as the reference index in predicting the survival outcome of cancer patients with COVID-19.
Role of misfolded tau in the onset and progression of brain toxicity after trauma
Authors: Diomede Luisa , Zanier Elisa R. , Barzago Maria Monica , Vegliante Gloria , Romeo Margherita , Bertani Ilaria , Natale Carmina , Colnaghi Luca , Colombo Laura , Russo Luca , Micotti Edoardo , Fioriti Luana , Chiesa Roberto 
Published: August 2020

Abstract
Background

Traumatic brain injury (TBI) is associated with widespread tau pathology in about thirty percent of patients surviving late after injury. We previously found that TBI in mice induces a transmissible tau pathology (tauTBI), with late cognitive decline and synaptic dysfunction. However, it is not clear whether tauTBI is a marker of ongoing neurodegeneration or a driver of functional decline. We employed the nematode C. elegans, which can recognize pathogenic forms of misfolded proteins, to investigate whether tauTBI is the primary toxic culprit in post-TBI neurodegeneration.
Methods

We developed an original approach involving the administration of brain homogenates from TBI mice to C. elegans, a valuable model for rapidly investigating the pathogenic effects of misfolded proteins in vivo. Brain homogenates from transgenic mice overexpressing tau P301L, a tauopathy mouse model, as well as pre-aggregated recombinant tau were employed to test whether abnormal tau conformers play a causal role in driving toxicity in TBI.
Results

Worms given brain homogenates from chronic but not acute TBI mice, or from mice in which tauTBI had been transmitted by intracerebral inoculation, had impaired motility and neuromuscular synaptic transmission. Results were similar when worms were exposed to brain homogenates from transgenic mice overexpressing tau P301L, a tauopathy mouse model, suggesting that TBI-induced and mutant tau have similar toxic properties. Harsh protease digestion to eliminate the protein component of the homogenates or pre-incubation with anti-tau antibodies abolished the toxicity. Homogenates of chronic TBI brains from tau knock-out mice were not toxic to C. elegans, whereas pre-aggregated recombinant tau was sufficient to impair their motility.
Conclusions

These results support a vital role of abnormal tau species in chronic neurodegeneration after TBI supporting the idea that targeting pathological tau may point to a therapeutic opportunity in trauma, and set the groundwork for the development of a C. elegans-based platform for screening anti-tau compounds.
Incidence and determinants of newborn mortality in the first three days of delivery in Northwestern Ethiopia: a prospective cohort study
Authors: Worke Mulugeta Dile , Mekonnen Afework Tadele , Limenih Simachew Kassa 
Published: August 2020

Abstract
Background: Addressing, the target of sustainable development goals of reducing perinatal mortality, was still a global challenge, and the magnitude of newborn death in the first three days of life takes a significant role in Ethiopia. Therefore, this study planned to determine the incidence and determinants of neonatal mortality in the first three days among babies delivered in referral hospitals of Amhara Regional State, North-Western Ethiopia. Method: A hospital-based prospective cohort study design was conducted among 810 early neonates in the first three days of delivery between March 1 and August 30, 2018. The neonates were followed, starting from the time of admission to 72 hours. An interviewer-administered questionnaire and medical record review were conducted for data collection. Data were entered into Epi-data manager version 4.4 and analyzed using STATA™ version 16.0 for the analysis. Cox-Proportional hazard model was used to determine the survival time of the newborns. Results: The overall incidence of newborn mortality in this study was 151/1,000 births. Neonatal mortality was significantly high among newborns whose mothers came between 17 and 28 weeks of gestation for the first visit [AHR=1.67;95% CI: 1.02, 2.73], among those whose mothers labor was not monitored with a partograph [AHR=2.66; 95% CI: 1.70, 4.15], mothers experience postpartum hemorrhage [AHR 2.88; 95% CI: 1.69, 4.89], develop fistula in the first 24 hours [AHR=3.75; 95% CI: 1.23, 11.43], and experience obstructed labor [AHR=2.14; 95% CI: 1.35, 3.38]. However, it was 39% less risky among newborns whose mothers were directly admitted, and whose mothers had visited health facilities in less than 1-hour, both [AHR=0.61; 95% CI: 0.38, 0.97]. Conclusion: This study revealed that about 1 in 7 newborns died in the early three days of life. The timing of the first antenatal visit, quality of labor monitoring, maternal complications, and delay in seeking the care were found to be the determinants. Thus, scaling-up of evidence-based interventions, and harmonized efforts aimed to improve the quality of antenatal care, promote institutional deliveries, provide optimal essential and emergency obstetric care, and ensure immediate postnatal care may improve neonatal survival.
Project PROPHET : Brief report of preliminary results
Authors: Garyfallos Alexander 
Published: August 2020

Abstract
Forecasting forthcoming "health events" is an extremely challenging task for the Remote Patient Monitoring systems (RPM systems) sector, which relies in real time information and communication technologies. Remote patient monitoring is a medical service which includes following and observing patients that are not in the same location with their health care provider. In general, the patient is equipped with a “smart” monitoring device, and the recorded data (vital signs) are securely transmitted via telecommunication networks to the health care provider. Modern remote patient monitoring devices are small, discrete and easy to wear, allowing "bearers" to move freely and with comfort. In this framework, MOKAAL pc has developed the IFS_RPM service (Integrated Facilitation Services for Remote Patient Monitoring) supplying the necessary ICT infrastructure, which is necessary for the provision of the RPM services. Following the completion of IFS_RPM project, MOKAAL pc launched a research project under the code name "PROPHETTM" .PROPHETTM main objective is to investigate the possibilities of introducing a real time predicting model based on remotely collected vital signs, that would utilize time series of metric data in conjunction with the information stored in the Electronic Health Records (EHR) of the "bearer", attempting to predict in real time, the probability of a "health event" occurring in the near future.To meet this objective, the PROPHETTM project team designed an evolutionary prototype of the "health event" forecasting model, which was developed and tested in a laboratory environment and it will be upgraded to a working prototype to be tested in real conditions, in order to be incorporated into the IFS_RPM system, after reaching its maturity state.
NeoLISA - A new method of surfactant administration developed based on in situ simulation&nbsp;
Authors: Kalane Shilpa , Rajhans Arti , Joshi Rajan 
Published: August 2020

Abstract
Background: Respiratory distress syndrome (RDS) caused by surfactant deficiency is the major cause of respiratory distress in preterm neonates. Despite the advances in preventive interventions, RDS may still develop and be associated with acute and or chronic complications. Exogenous surfactant therapy is effective in reducing RDS related mortality and morbidity. Due to the complications of surfactant administration, minimal or less invasive administration techniques have been developed and appear promising. Objective: To address the knowledge gaps in less invasive surfactant administration technique at the level of the health care worker (HCW). Methodology: Four simulation-training sessions were conducted in April 2020, two before and two after the NeoLISA technique was developed. The neonatal clinical team consisted of neonatology specialists and neonatal nurses. Results: Each simulation session lasted for around 30 minutes including debriefing. The learnings during this process were discussed and the new technique of NeoLISA was developed. The key change was the development to confirm the catheter position.Conclusion: A new method for surfactant administration was developed. An innovative bedside clinical method confirming catheter position into the trachea has been developed.
Exploring Network Security Using Vigenere Multiplicative Cipher Encryption and Implementation
Authors: Biswas Milon , Sakeef Nazmus , Siddique Hisham 
Published: August 2020

Abstract
Various types of encryption technologies have been used for many years to protect information. The purpose of this article is to create a new method called Vigenere-Multiplicative cipher. Here we develop an algorithm and its algebraic description. In addition, it provides frequency analysis for this method. In addition, a brief description of the method implementation, security attacks, and comparisons between specific ciphers and the most common ciphers.
Association Between Blood Lipid Profile and the Incident CKD in the General Chinese Population: A Retrospective Study
Authors: Liu Jian , Yu Geping , Yu Xialian , Liu Yunzi , Wang Weiming 
Published: August 2020

Abstract
Background: Prevalence of dyslipidemia in china is rising and the pattern of dyslipidemia in china is different from western countries. Our study aimed to investigate the association between hyperlipidemia and chronic kidney disease in the general population.Methods: We conducted a retrospective, longitudinal cohort study of a health examination center database in China. Subjects who had at least three visits from 2011 to 2018 with normal baseline eGFR were enrolled. We evaluated the association of the lipid parameters with the incident chronic kidney diseases. Results: Totally, 8087 participants without kidney damage were identified. After the mean 5.51 years follow-up, 211 participants developed chronic kidney disease. Compared to non-CKD, participants developing CKD had lower baseline HDL-c (1.35±0.36 vs 1.24±0.36 mmol/L, p<0.001) and higher Lg(triglyceride) (0.15±0.27 vs 0.19±0.24, p=0.037). There was no difference of LDL-c (2.72±0.72 vs 2.72±0.71 mmol/L, p= 0.971) and total cholesterol (4.86±0.92 vs 4.80±0.89 mmol/L, p= 0.329) in two groups. Multi-variable logistic analysis showed that lower HDL-c was an independent risk of incident CKD (OR [95%] =1.61[1.02, 2.55], P=0.04) in participants.Conclusion: A lower HDL-c affects incident CKD in Chinese general population.
Regional and chronological differences in prevalences of olfactory and gustatory dysfunction in coronavirus disease (COVID-19): a systemic review and meta-analysis
Authors: Kim Jeong-Whun , Han Seung Cheol , Jo Hyung Dong , Cho Sung-Woo , Kim Jin Youp 
Published: August 2020

Abstract
Olfactory and gustatory dysfunction are frequently reported in patients with coronavirus disease (COVID-19). However, the reported prevalence of olfactory and/or gustatory dysfunction varies widely, and the reason for the inter-study differences is unclear. Hence, in this meta-analysis, we performed subgroup analyses to investigate the factors that contribute to the inter-study variability in the prevalence of olfactory and gustatory dysfunction. Out of 943 citations, we included 55 eligible studies with 13,527 patients with COVID-19 for a systematic review. The overall pooled prevalences of olfactory and gustatory dysfunction were 51.4% and 47.5%, respectively, in the random-effect model. In subgroup analyses, the prevalences of olfactory and gustatory dysfunction were significantly different among four geographical regions (both P < 0.001, respectively). Although the prevalences of olfactory and gustatory dysfunction did not significantly differ according to the time of enrollment, the subgroup analyses including only studies from the same geographical region (Europe) revealed a significant difference in olfactory dysfunction according to the time of enrollment. The regional and chronological differences in the prevalences of olfactory and gustatory dysfunctions partly explain the wide inter-study variability.
Deep learning for COVID-19 chest CT (computed tomography) image analysis: a lesson from lung cancer
Authors: Jiang Hao , Tang Shiming , Liu Weihuang , Zhang Yang 
Published: August 2020

Abstract
As a recent global health emergency, the quick and reliable diagnosis of COVID-19 is urgently needed. Thus, many artificial intelligence (AI)-base methods are proposed for COVID-19 chest CT (computed tomography) image analysis. However, there are very limited COVID-19 chest CT images publicly available to evaluate those deep neural networks. On the other hand, a huge amount of CT images from lung cancer are publicly available. To build a reliable deep learning model trained and tested with a larger scale dataset, we build a public COVID-19 CT dataset, containing 1186 CT images synthesized from lung cancer CT images using CycleGAN. Additionally, various deep learning models are tested with synthesized or real CT images for COVID-19 and non-COVID-19 classification. In comparison, all models achieve excellent results (over than 90%) in accuracy, precision, recall and F1 score for both synthesized and real COVID-19 CT images, demonstrating the reliable of the synthesized dataset. The public dataset and deep learning models can facilitate the development of accurate and efficient diagnostic testing for COVID-19.
CD4 T cells of prostate cancer patients have decreased immune responses to antigens derived from SARS-CoV-2 spike glycoprotein
Authors: Taborska Pavla , Strizova Zuzana , Stakheev Dmitry , Sojka Ludek , Bartunkova Jirina , Smrz Daniel 
Published: August 2020

Abstract
The adaptive immune response to severe acute respiratory coronavirus 2 (SARS-CoV-2) is important for vaccine development and coronavirus disease 2019 (COVID-19) recovery. Men and cancer patients have been reported to be at higher risks of contracting the virus and developing severe COVID-19. Prostate cancer (PCa) may be associated with both of these risks. We show that CD4+ T cells of SARS-CoV-2-unexposed patients with hormone-refractory (HR) metastatic PCa have substantially decreased CD4+ T cell immune responses to antigens from SARS-CoV-2 spike glycoprotein but not from the spiked glycoprotein of the 'common cold'-associated human coronavirus 229E (HCoV-229E) as compared with healthy male volunteers. Moreover, the HCoV-229E spike glycoprotein antigen-elicited CD4+ T cell immune responses cross-reacted with the SARS-CoV-2 spiked glycoprotein antigens. PCa patients may not respond to the vaccination, and the cross-reactivity can mediate antibody-dependent enhancement (ADE) of COVID-19. These findings highlight the potential for increased vulnerability of PCa patients to COVID-19.