bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coupled blue and red light-emitting diodes therapy efficacy in patients with rosacea: two case reports
Authors: Sorbellini Elisabetta , De Padova Maria Pia , Rinaldi Fabio 
Published: January 2020

AbstractBackgroundRosacea is a common inflammatory skin condition affecting approximately 5% of the world population. Therapeutic approaches to rosacea are focused on symptom suppression by means of anti-inflammatory agents. More recently, photodynamic therapy, especially light-emitting diodes, has been introduced as a valid alternative to conventional therapy.Case presentationIn the present work, we reported the efficacy and safety of light-emitting diodes therapy combining blue (480 nm) and red (650 nm) light for the treatment of two patients with papulopustular rosacea: a 22-year-old Caucasian woman and a 68-year-old Caucasian man.ConclusionsThis kind of treatment could represent an effective, safer, and well-tolerated approach for the treatment of such conditions.
Exosomes from bone marrow mesenchymal stem cells enhance fracture healing through the promotion of osteogenesis and angiogenesis in a rat model of nonunion
Authors: Zhang Lu , Jiao Guangjun , Ren Shanwu , Zhang Xiaoqian , Li Ci , Wu Wenliang , Wang Hongliang , Liu Haichun , Zhou Hongming , Chen Yunzhen 
Published: January 2020

Abstract
Background
As important players in cell-to-cell communication, exosomes (exo) are believed to play a similar role in promoting fracture healing. This study investigated whether exosomes derived from bone marrow mesenchymal stem cells (BMMSC-Exos) could improve fracture healing of nonunion.

Methods
BMMSC-Exos were isolated and transplanted into the fracture site in a rat model of femoral nonunion (Exo group) every week. Moreover, equal volumes of phosphate-buffered saline (PBS) and exosome-depleted conditioned medium (CM-Exo) were injected into the femoral fracture sites of the rats in the control and CM-Exo groups. Bone healing processes were recorded and evaluated by radiographic methods on weeks 8, 14 and 20 after surgery. Osteogenesis and angiogenesis at the fracture sites were evaluated by radiographic and histological methods on postoperative week 20. The expression levels of osteogenesis- or angiogenesis-related genes were evaluated in vitro by western blotting and immunohistochemistry. The ability to internalize exosomes was assessed using the PKH26 assay. Altered proliferation and migration of human umbilical vein endothelial cells (HUVECs) and mouse embryo osteoblast precursor cells (MC3TE-E1s) treated with BMMSC-Exos were determined by utilizing EdU incorporation, immunofluorescence staining, and scratch wound assay. The angiogenesis ability of HUVECs was evaluated through tube formation assays. Finally, to explore the effect of exosomes in osteogenesis via the BMP-2/Smad1/RUNX2 signalling pathway, the BMP-2 inhibitors noggin and LDN193189 were utilized, and their subsequent effects were observed.

Results
BMMSC-Exos were observed to be spherical with a diameter of approximately 122 nm. CD9, CD63 and CD81 were expressed. Transplantation of BMMSC-Exos obviously enhanced osteogenesis, angiogenesis and bone healing processes in a rat model of femoral nonunion. BMMSC-Exos were taken up by HUVECs and MC3T3-E1 in vitro, and their proliferation and migration were also improved. Finally, experiments with BMP2 inhibitors confirmed that the BMP-2/Smad1/RUNX2 signalling pathway played an important role in the pro-osteogenesis induced by BMMSC-Exos and enhanced fracture healing of nonunion.

Conclusions
Our findings suggest that transplantation of BMMSC-Exos exerts a critical effect on the treatment of nonunion by promoting osteogenesis and angiogenesis. This promoting effect might be ascribed to the activation of the BMP-2/Smad1/RUNX2 and the HIF-1α/VEGF signalling pathways.
Oral administration of porcine epidemic diarrhea virus spike protein expressing in silkworm pupae failed to elicit immune responses in pigs
Authors: Chang Chia-Yu , Hsu Wei-Ting , Tsai Pei-Shiue , Chen Chi-Min , Cheng Ivan-Chen , Chao Yu-Chan , Chang Hui-Wen 
Published: January 2020

AbstractThe silkworm (Bombyx mori) and its pupae have been used for decades as nutritional additives and applied on the production of high-quality recombinant proteins via the baculovirus expression vector (BEV) system. The bio-capsule, the fat-rich body, and some body components of the silkworm pupae, which deliver antigens passing through the harsh environment of digestive tract and reaching the intestine, have been used as a vehicle for oral vaccines. In the present study, to develop a novel oral vaccine against porcine epidemic diarrhea virus (PEDV), the PEDV spike (S) protein was expressed in silkworm pupae and BmN cells using the BEV system. After three doses of oral administrations with 2-week intervals in pigs, neither PEDV S protein-specific humoral nor mucosal immune responses can be detected. The failure of eliciting the PEDV-specific immune response suggested that the BEV system using BmN cells or silkworm pupae as oral immunogen-expression vehicles was not able to overcome the immunological unresponsiveness, which was possibly due to gastrointestinal specific barriers and oral tolerance. Better strategies to enhance the delivery and immunogenicity of oral vaccines should be further investigated. Nevertheless, the PEDV S protein generated in the BmN cells and silkworm pupae herein provides an efficient tool to produce the recombinant antigen for future applications.
Neuromuscular blockade in acute respiratory distress syndrome: a systematic review and meta-analysis of randomized controlled trials
Authors: Ho An Thi Nhat , Patolia Setu , Guervilly Christophe 
Published: January 2020

Abstract
Background
Neuromuscular blocking agent (NMBA) has been proposed by medical guidelines for early severe acute respiratory distress syndrome (ARDS) because of its survival benefits. However, new studies have provided evidence contradicting these results.

Method
A search was performed of the Pubmed, Scopus, Clinicaltrials.gov, and Virtual Health Library databases for randomized controlled trials (RCT) evaluating 28-day mortality in ARDS patients treated with NMBA within 48 h. An English language restriction was applied. Relevant data were extracted and pooled into risk ratios (RR), mean differences (MD), and corresponding 95% confidence intervals (CI) using random-effect model. Sensitivity and meta-regression analysis were performed.

Results
From 2675 studies, we included five RCTs in the analysis, for a total of 1461 patients with a mean PaO2/FIO2 of 104 ± 35 mmHg. The cisatracurium group had the same risk of death at 28 days (RR, 0.90; 95% CI, 0.78–1.03; I2 = 50%, p = 0.12) and 90 days (RR, 0.81; 95% CI, 0.62–1.06; I2 = 56%, p = 0.06) as the control group (no cisatracurium). The secondary outcomes of mechanical ventilation duration and ventilator-free days were not different between the two groups. Cisatracurium had a significantly lower risk of barotrauma than the control group with no difference in intensive care unit (ICU)–induced weakness. The PaO2/FIO2 ratio was higher in the cisatracurium group but not until 48 h. Meta-regression analysis of the baseline PaO2/FIO2 ratio, positive end-expiratory pressure (PEEP) revealed no heterogeneity. Subgroup analysis excluding the trial using high PEEP and light sedation strategy yielded an improvement in all mortality outcomes.

Conclusion
NMBA improves oxygenation only after 48 h in moderate, severe ARDS patients and has a lower barotrauma risk without affecting ICU weakness. However, NMBA does not reduce ventilator-free days, duration of mechanical ventilation or, most importantly, the mortality risk regardless of the severity of ARDS.
Unlocking the potential for digital mental health technologies in the UK: a Delphi exercise
Authors: Murphy Clare , Thorpe Lucy , Trefusis Harriet , Kousoulis Antonis 
Published: January 2020

Background
Digitally enabled services can contribute to the support, treatment and prevention of mental health difficulties; however, questions remain regarding how we can most usefully harness such technology in primary and secondary mental healthcare settings.

Aims
To identify barriers and facilitators to enable the potential of digital mental health in England, Scotland, Wales and Northern Ireland.

Method
A three-round Delphi exercise was carried out online with 16 participants from across the four nations of the UK representing the following stakeholder groups: service providers, health professionals, policymakers, lived experience, small and medium enterprises and academics. Qualitative data were collected in the first round (80 fragments) that were then coded to produce a 26-item round-two questionnaire for participant rating. Participants were given the opportunity to reconsider their scores in light of the group responses in round three.

Results
Eight statements under the following five themes reached consensus with median scores between 8 and 10 (i.e. important/very important): co-production; the human element; data security; funding; and regulation.

Conclusions
The Delphi process allowed consensus to be achieved regarding the factors that experts consider important for harnessing technology in primary and secondary mental healthcare. Knowledge of these factors can help users and providers of mental health services negotiate how best to move forward with digitally enabled systems of care.
Bone Health and Bone-Targeted Therapies for Prostate Cancer: ASCO Endorsement of a Cancer Care Ontario Guideline
Authors: Saylor Philip J. , Rumble R. Bryan , Tagawa Scott , Eastham James A. , Finelli Antonio , Reddy Pavan S. , Kungel Terry M. , Nissenberg Merel G. , Michalski Jeff M. 
Published: January 2020

PURPOSE In 2017, Cancer Care Ontario’s Program in Evidence-Based Care released the Bone Health and Bone-Targeted Therapies for Prostate Cancer guideline. This guideline included recommendations across a relatively broad clinical spectrum within prostate cancer. Topics addressed ranged from management of osteoporotic fracture risk in nonmetastatic disease to management of men with castration-resistant prostate cancer metastatic to bone. ASCO has a policy and set of procedures for endorsing clinical practice guidelines that have been developed by other professional organizations. METHODS The Bone Health and Bone-Targeted Therapies for Prostate Cancer guideline was reviewed for developmental rigor by methodologists. An ASCO Expert Panel then reviewed the content and the recommendations. RESULTS The ASCO Expert Panel determined that the recommendations from the Bone Health and Bone-Targeted Therapies for Prostate Cancer guideline were clear, thorough, and based on the most relevant scientific evidence. ASCO wholly endorses the Bone Health and Bone-Targeted Therapies for Prostate Cancer guideline. RECOMMENDATIONS The ASCO Expert Panel endorses all the original guideline recommendations as written and offers a series of discussion points to guide practice for clinicians as they manage bone-related risks within this patient population.
Humanitarian Detention and Figures of Persistence at the Border
Authors: Sanyal Debarati 
Published: January 2020

Abstract
Starting with Alan Kurdi as the “ideal” figure of the refugee, juxtaposed with the figure of the migrant swarm, which rehearses the contrast between humanitarian compassion and securitarian anxiety, this essay traces how these seemingly opposed logics meet in the “humanitarian” detention of children at Europe's borders. This essay examines the partial reinscription of colonial histories and their racist aftermaths in current technologies of surveillance, capture and detention. Adapting the figure of the Möbius strip to envision the relationship between camp and polis, the essay analyzes an experimental documentary on migrant detention at the Greek-Turkish border. In Blue Sky from Pain, by Stephanos Mangriotis and Laurence Pillant, detention sites contain unpredictable subjectivations, forms of dissent, and figures of persistence, even when the detainees are children. The film puts pressure on the frames by which we imagine the subject of human rights and the object of humanitarian compassion.
Fibroblast growth factor-6 enhances CDK2 and MATK expression in microvesicles derived from human stem cells extracted from exfoliated deciduous teeth
Authors: Othman Ahmed , Mubarak Rabab , Sabry Dina 
Published: January 2020

Background: Stem cells from human exfoliated deciduous teeth (SHEDs) are considered one of the most convenient sources of adult stem cells. This study aimed to examine the effect of fibroblast growth factor 6 (FGF-6) on SHEDs and evaluate CDK2 and MATK gene expression in SHED-derived microvesicles (MVs). SHEDs were cultured from deciduous teeth pulp. Methods: SHEDs were divided into two groups: the control group and test groups, with and without FGF-6 supplementation, respectively. After the third passage, SHED proliferation was assessed by MTT assay. MVs were purified and CDK2 and MATK gene expression was assessed by real-time polymerase chain reaction. SHEDs were identified by their positivity for CD90 and CD73, and negativity for CD45 and CD34. Results: SHEDs proliferation in the test group was significantly higher than in the control group (P<0.001). mRNA from SHED-derived MVs from the test group exhibited a markedly elevated expression of CDK2 and MATK, (P<0.002 and P<0.005, respectively) in comparison with those of the control group. FGF-6 enhanced the proliferation of SHEDs. Proliferation enhancement is favorable for the production of a large number of stem cells, which will then be beneficial for cell-based therapies. Conclusions: CDK2 and MATK genes in SHED-derived MVs can be used as molecular biomarkers for SHED proliferation.
Pelaksanaan KKN Berparadigma Integrasi-Interkoneksi dalam Menopang Transformasi Masyarakat (Sebuah Rintisan Pendekatan Participatory Action Research)
Authors: Salehudin Ahmad 
Published: January 2020

KKN merupakan bagian integral sistem pendidikan tinggi. Oleh karena itu, sering perubahan IAIN menjadi UIN Sunan Kalijaga Yogyakarta, dimana paradigm keilmuannya juga berubah menjadi integrasi-interkoneksi, KKN UIN Sunan Kalijaga Yogyakarta seyogyanya juga menganut paradigm tersebut. Berdasarkan hal tersebut, ada dua hal yang ingin dijawab dari tulisan ini, yaitu bagaimana paradigma integrasi-interkoneksi dirumuskan dan dilaksanakan dalam bentuk program kerja, dan apa factor penghambat dan pendoroangnya. Untuk menjawab persoalan tersebut, penulis melakukan penelitian di dua lokasi KKN di dusun Sanggrahan dan Rajek Wetan dengan peserta 30 orang. Agar tidak semata-mata teoritis, penelitian ini metode semi participatory action research. Berdasarkan hasil penelitian, diketahui bahwa untuk merumuskan KKN Integratif-interkonektif perlu kesadaran bahwa antarilmu (agama dan sekular) harus saling terkait untuk menyelesaikan problem masyarakat. Hambatan yang sering terjadi adalah ketidak pahaman mahasiswa atas peran yang harus dilakukan sebagai peserta KKN.
Gagasan dan Pemikiran Muhammadiyah Tentang Kaderisasi Ulama (Studi Kasus tentang Ulama di Muhammadiyah)
Authors: Isnanto Muh. 
Published: January 2020

Pendidikan Islam bukan sekedar proses penanaman nilai-nilai moral untuk membentengi diri dari ekses negatif globalisasi. Tetapi yang terpenting adalah bagaimana nilai-nilai moral yang telah ditanamkan pendidikan Islam mampu berperan sebagai kekuatan pembebas (liberating force) dari himpitan kemiskinan, kebodohan, keterbelakangan sosial budaya dan ekonomi (Syafi’i Ma’arif). Ada kegelisahan terhadap pengkaderan ulama di kalangan pengasuh dan pendidik sehingga muncul pertanyaan "akan dibawa kemana pemikiran kaderisasi ulama ini?" atau "bagaimana sistem pengkaderannya?". Ghiroh pengkaderan adalah mencetak ulama sebagai sumber daya manusia yang berkualitas dan berkeadaban. Hasil penelitian menunjukkan bahwa di Muhammadiyah memang sedang terjadi krisis ulama, bahkan ada yang lebih ekstrim lagi krisis da’i, yaitu kiris ulama yang intelektual dan intelektual yang ulama. Kedua, faktor-faktor yang menyebabkan ada 2 yaitu faktor internal bersifat kelembagaan. Kurang berfungsinya struktur kelembagaan di persyarikatan Muhammadiyah menyebabkan tidak berfungsinya lembaga-lembaga yang ada mulai dari tingkat Pusat hingga tingkat ranting. Sedangkan faktor eksternalnya adalah pembentukan pola pikir yang ditinggalkan pemerintah kolonial, menguatnya tarikan dan kepentingan politik yang masuk ke lingkungan Persyarikatan serta standar ulama di Muhammadiyah terlalu tinggi, sehingga tidak banyak yang bisa masuk kategori ini. Ketiga, problem solving untuk mengatasi terjadinya krisis Ulama di Muhammdiyah melalui kelembagaan maupun sosial. Secara kelembagaan, adanya kesadaran kolektif akan pentingnya pengkaderan ulama, dan secara sosial adanya kesadaran warga Muhammadiyah akan pendidikan kader ulama.
Orang Madura Perantauan di Daerah Istimewa Yogyakarta
Authors: Syamsuddin Muh 
Published: January 2020

Pada tulisan ini dapat diketahui bahwa semua perantau Madura di Daerah Istimewa Yogyakarta adalah beragama Islam. Norma-norma agama berusaha mereka laksanakan dengan sebaik-baiknya dalam kehidupan sehari-hari. Di samping itu, para perantau ini sangat erat dengan agama mereka, dan memakainya sebagai identitas diri karena Islam memberi perasaan bangga terhadap mereka. Pemahaman mereka tentang agama mengalami berbagai perubahan sesuai dengan perubahan nilai itu sendiri. Perubahan nilai maupun pemahaman terhadap ajaran agama dapat disebabkan oleh perubahan dalam interaksi sesama perantau Madura itu sendiri atau pun karena pengaruh yang di dapat dari luar. Dalam hal ini, sikap solidaritas dan sikap pragmatisme masih mendasari sebagian besar dari perantau Madura ini, demikian halnya termasuk menjelaskan budaya remoh atau kesukaan menabung dengan cara tradisional masih ditemui di kalangan mereka di tengah makin tingginya pola konsumtif masyarakat. Penampilan mereka sederhana, lugu, polos, mengutamakan hidup kekeluargaan dan gotong royong, pekerja keras, ulet dan tingkat survivalnya tinggi. Selain itu, mereka mudah beradaptasi atau dapat menyesuaikan diri dengan lingkungan yang ada, barangkali berakar dari sikap pragmatisme.
Tunggakan Perkara di Lingkungan Peradilan Agama dan Upaya Penanggulangannya
Authors: Ibrahim Malik 
Published: January 2020

Artikel ini dilatarbelakangi oleh fenomena semakin tingginya tunggakan perkara di lingkungan Peradilan Agama (PA), yang dari waktu ke waktu semakin bertambah. Secara umum penyebab terjadinya tunggakan perkara adalah adanya perbedaan antara jumlah perkara yang masuk (input) dengan jumlah perkara yang dapat diselesaikan (out put). Fenomena tersebut secara umum disebabkan keterbatasan kemampuan PA dalam menyelesaikan tunggakan perkara, baik secara kualitas maupun kuantitas. Sehingga berakibat proses peradilan tidak berjalan secara cepat atau lambatnya penyelesaian suatu perkara. Dari latar belakang masalah di atas, maka artikel ini berupaya menjelaskan dua hal yaitu: faktor penyebab terjadinya tunggakan perkara di lingkungan PA dan upaya yang dapat dilakukan dalam menanggulangi tunggakan perkara di lingkungan PA.
SOME ASPECTS OF THE ASSESSMENT OF ANAEROBIC CAPACITY IN COMBAT ATHLETES
Authors: Zotova F , Mavliev F , Nazarenko A , Zemlenukhin I , Razzhivin O 
Published: January 2020

Aim. The article deals with the assessment of anaerobic capacity in wrestlers depending on wrestling style and morphological indicators. Materials and methods. 33 male wrestlers participated in the experiment. All participants are apparently healthy people at the moment of the study and have their sports grades (from 1st grade to the Master of Sport). The test was conducted with the Monark 891E arm ergometer (Switzerland). The following parameters were obtained during the experiment: peak power (W), average power (W), time to peak power (ms). Results. Power was assessed with an arm ergometer. This power is mostly achieved by the muscles responsible for arm flexion and extension in the shoulder joint and, to a lesser extent, by the biceps and triceps responsible for flexion and extension in the elbow joint. This statement is based on the correlations between the peak power, average power, and chest circumference, which look as following: r = 0.58 ± 0.019 (р = 0.0006) and r = 0.68 ± 0.15 (р < 0.0001). At the same time, shoulder circumference is less correlated with power, while chest circumference correlates with the average power in a more pronounced way than body weight does (r = 0.68 ± 0.15 against r = 0.58 ± 0.19, at р = 0.049 – one-way analysis). Therefore, in wrestlers, it is necessary to take into account chest circumference, which will allow predicting the potential power of the locomotion connected with the shoulder girdle (in case if the test is adjusted to a specific wrestling style), as well as the degree of shoulder girdle muscles development and training as one of the important predictors of successful combat. Conclusion. There are statistically significant correlations between the morphological indicators of wrestlers and their power. This can be used for the assessment of motor qualities depending on chest circumference, shoulder circumference, and skin-fat folds. It will be helpful for estimating a potential power and the efficiency of the training process as one of the main predictors of successful combat, especially at the first stages of multiyear training.
POLA PERKEMBANGAN PERUMAHAN DI KOTA SURAKARTA
Authors: Widodo Widodo , Sunarti Sunarti 
Published: January 2020

Sektor perkembanagan perumahan di Kota Surakarta mengalami perkembangan yang sangat pesat. Pertumbuhan penduduk baik alami maupun migrasi yang pesat membuat kebutuhan akan lahan di perkotaan semakin menjadi tantangan serius. Seperti halnya Kota Surakarta dengan lokasi strategis yaitu ditengah – tengah Pulau Jawa dan menjadi pusat kota dari daerah di sekitarnya menjadikan pertumbuhan Kota Surakarta menjadi pesat . tujuan dari penelitian ini adalah menidentifikasi pola sebaran perumahan untuk melihat kebutuhan sarana prasarana dan utilitas di Kota Surakarta. Studi ini menggunakan metode kuantitatif untuk menggambarkan perkembangan pertumbuhan perumahan terkait pola sebaran di Kota Surakarta. Mengadopsi analisa tetangga terdekat (nearest neighborhood) untuk mengetahui pola sebaran perumahan. Hal ini karena segudang permasalahan di berbagai aspek yang perlu di benahi bersama mulai dari pemerintah sampai masyarakat.
ÖZ ETKİNLİK ÖLÇEĞİ’NİN PSİKOMETRİK ÖZELLİKLERİ
Authors: ÖZALP TÜRETGEN İlknur , CESUR Sevim 
Published: January 2020

Bu çalışmanın amacı, Cesur ve Özalp Tiiretgen [2] tarafından Türkçe’ye çevrilen Öz Etkinlik Ölçeği’nin [1] psikometrik özelliklerinin daha ileri derecede incelenmesidir. Öz etkinlik, kişinin kendisine atfettiği bütün önemli başarı ve başarısızlıkların bir toplamıdır. Ölçek, farklı sektörlerde görev yapan beyaz yakalı çalışanlara uygulanmıştır. En az lise mezunu olan katılımcıların 132’si kadın, 105’i erkektir. Ölçeğin güvenilirliği için hesaplanan Cronbach Alfa değeri .84 bulunmuştur. Geçerliliğe yönelik olarak faktör analizi uygulandığında orijinalinden farklı olarak, “Zorluklara Atılma-Mücadele”, “İşe Başlama-Tamamlama” ve “Sosyal Etkinlik” olarak isimlendirilen, 19 maddeli ve üç boyutlu bir yapı ortaya çıkmıştır. Yine geçerlilik için ölçeğin, Kontrol Odağı, Atılganlık ve Nörotiklik yapılarıyla ilişkisi incelenmiştir. Ölçek, beklendiği gibi atılganlıkla pozitif, kontrol odağı ve nörotiklikle de negatif yönde anlamlı korelasyona sahiptir. Bu veriler ölçeğin güvenilirliğine ve geçerliliğine yönelik deliller sunmaktadır.
Ayrıca öz etkinlikle cinsiyet ve yaş değişkeninin ilişkisi de incelenmiştir. Ancak öz etkinlikle bu değişkenler arasında anlamlı bir ilişki bulunamamıştır.