bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supplementing Ca salts of soybean oil to late-gestating beef cows: impacts on performance and physiological responses of the offspring
Authors: Brandão Alice Poggi , Cooke Reinaldo F , Schubach Kelsey M , Rett Bruna , Souza Osvaldo A , Schachtschneider Christopher L , Perry George A , Arispe Sergio A , Jump Donald B , Pohler Ky G , Bohnert David W , Marques Rodrigo S 
Published: August 2020

AbstractThis experiment compared the performance and physiological responses of the offspring from cows supplemented with Ca salts of soybean oil (CSSO) or prilled saturated fat (CON) during late gestation. Nonlactating, pregnant, multiparous Angus × Hereford cows (n = 104) that conceived during the same fixed-time artificial insemination protocol were assigned to this experiment. Cows were ranked by pregnancy sire (one of two sires), body weight (BW), and body condition score (BCS) on day −15 of the experiment (day 180 of gestation). Cows were then assigned to receive (dry matter basis) 415 g of soybean meal per cow daily in addition to: 1) 195 g/cow daily of CSSO (n = 52) or 2) 170 g/cow daily of CON (n = 52). Cows were maintained in two pastures (26 cows/treatment per pasture) and received daily 12.7 kg/cow (dry matter basis) of grass-alfalfa hay from day −15 to calving. Cows were segregated into 1 of 24 feeding pens three times weekly and received treatments individually from day 0 to calving. Calves were weaned on day 290 of the experiment, preconditioned for 35 d (day 291 to 325), and transferred to a feedyard, where they remained until slaughter (day 514). Cows receiving CSSO and their calves had greater (P &lt; 0.01) plasma concentrations of linoleic acid and total ω-6 PUFA compared with CON after calving. Concentrations of immunoglobulin G in the colostrum and in calf plasma 24 h after birth were greater (P ≤ 0.02) in CSSO vs. CON cattle. Calves from CSSO cows had greater (P ≤ 0.05) expression of adipogenic (adipocyte fatty acid-binding protein and stearoyl-CoA desaturase) and myogenic (myogenic differentiation 1 and myogenin) genes in the longissimus muscle (LM) compared with CON. No treatment differences in birth BW, weaning BW, and final preconditioning BW were noted (P ≥ 0.36). Average daily gain and final BW in the feedyard were greater (P ≤ 0.05) in steers from CSSO cows compared with CON. The incidence of calves diagnosed with BRD that required a second antimicrobial treatment was less (P = 0.03) in calves from CSSO cows, resulting in reduced (P = 0.05) need of treatments to regain health compared with CON. Upon slaughter, LM area was greater (P = 0.03) in calves from CSSO cows compared with CON. Collectively, these results are indicative of programming effects on postnatal offspring growth and health resultant from CSSO supplementation to late-gestating cows. Hence, supplementing CSSO to beef cows during pregnancy might be a feasible alternative to optimize offspring productivity and welfare.
Sap Beetles (Coleoptera: Nitidulidae) in Oak Forests of Two Northeastern States: A Comparison of Trapping Methods and Monitoring for Phoretic Fungi
Authors: DiGirolomo Marc F , Munck Isabel A , Dodds Kevin J , Cancelliere Jessica 
Published: August 2020

AbstractOak wilt is slowly expanding in the northeastern United States. Several nitidulid beetle species are known vectors of the fungus [Bretziella fagacearum (Bretz) Z. W. De Beer, Marinc., T. A. Duong, and M. J. Wingf (Microascales: Ceratocystidaceae)] that causes this disease, acquiring spores from fungal mats on infected trees and transmitting them to uninfected trees. Survey and fungal isolation from captured nitidulid beetles could be an important tool for detecting the presence of this disease in a geographic area not previously known to have oak wilt. In preparation for monitoring activities in such areas, two trapping studies were conducted in the northeastern United States: 1) trap test comparing the efficacy of wind-oriented pipe, multiple-funnel, and modified pitfall traps for nitidulids and 2) wet and dry collection cup comparison. Lures were a combination of nitidulid pheromones and fermenting liquid. Results support the use of multiple-funnel traps over the other two trap types, for both targeted species-specific surveys and community sampling. More total nitidulids, Colopterus truncatus (Randall), and Glischrochilus fasciatus (Olivier) were captured in wet collection cups compared with dry cups. Twenty-seven fungal species were isolated, none of which were B. fagacearum. Many fungi isolated from beetles were plant pathogens, indicating that in addition to the oak wilt fungus, sap beetles may contribute to the spread of other plant diseases.
Performance of a Low-Cost Acoustic Insect Detector System with Sitophilus oryzae (Coleoptera: Curculionidae) in Stored Grain and Tribolium castaneum (Coleoptera: Tenebrionidae) in Flour
Authors: Mankin R W , Jetter E , Rohde B , Yasir M 
Published: August 2020

Abstract
Reduction of postharvest losses is gaining increased priority in warm regions where insect infestation may cause rapid deterioration of staple commodities. Acoustic detection can be used to assess the likelihood of insect infestations in bags of grain, flour, and other commodities that are stored in small holdings in developing countries, enabling rapid targeting of treatments. A portable postharvest insect detection system was developed with the goal to provide low-cost capability to acoustically assess infestations in small-scale storage facilities. Electret microphones input pest insect sounds to a 32-bit microcontroller platform that digitized and stored the signals on a digital memory card transferable to a portable laptop computer. The insect sounds then were analyzed by custom-written software that matched their spectra to those of known pests. Infestations of Sitophilus oryzae (L) in 2.6-kg bags could be detected down to densities of 1.9 adults/kg in grain and Tribolium castaneum (Herbst) down to 3.8 adults/kg in flour in laboratory settings. Also, differences in the rates of sounds per insect in treatments with different numbers ranging from 5 to 50 insects suggested that the sound rates of adults of different species at different population densities may be noticeably affected by aggregation pheromones or other behaviorally active semiochemicals. Further testing is needed but previous experience with acoustic detection systems suggests that the prototype has potential for use in small storage facilities where early detection of infestations is difficult to provide.
The Quest for a European Safe Asset—A Comparative Legal Analysis of Sovereign Bond-Backed Securities, E-Bonds, Purple Bonds, and Coronabonds
Authors: Grund Sebastian 
Published: August 2020

Abstract
The European sovereign debt crisis and, more recently, the COVID-19 pandemic have revealed the European Economic and Monetary Union’s fragility, which essentially emanates from the inherent tension between a single monetary policy and decentralized fiscal policies. To cushion economic and financial shocks and sever the sovereign-bank doom loop, different proposals to create a common public debt security have been put forward, although none of them has so far seen the light of day. Building on pertinent economic and finance scholarship, this article reviews four promising safe asset proposals from a legal perspective: Sovereign bond-backed securities (SBBS), E-bonds, Purple bonds, and Coronabonds. Rather than focusing on their feasibility under EU law or national constitutional law, this article compares the proposals from an investor perspective against the backdrop of the following formal and functional legal characteristics that render assets ‘safe’: governing law, dispute settlement forum, investor protection, and investor representation in sovereign debt restructurings. Against this backdrop, targeted recommendations on critical design elements of safe assets, with the aim of reconciling the economic policy objectives with the pertinent legal constraints, are advanced.
Is the Quality of the ICC’s Legal Reasoning an Obstacle to Its Ability to Deter International Crimes?
Authors: Kjeldgaard-Pedersen Astrid 
Published: August 2020

Abstract
Given that the Rome Statute is only binding upon its member states, there is a certain element of judicial megalomania in the recurrent claim by the International Criminal Court (ICC) that it acts ‘on behalf of the international community as a whole’ in its endeavour to end impunity for international crimes. Focusing on recent ICC rulings concerning the nature and function of the Court, this article queries whether the quality of the Court’s legal reasoning may have an impact on its long-term deterrence potential. The article suggests that while making self-aggrandizing statements and stretching the boundaries of its legal mandate might, in principle, increase the short-term deterrent effect of the ICC, the Court risks sacrificing a greater good, i.e. its long-term status as a legitimate authority within the field international criminal law. Inconsistent rulings without a solid basis in sound legal analysis may indeed prove to be devastating for the ICC, which is still in the process of establishing itself as a credible institution that commands respect.
Antixenosis, Antibiosis, and Potential Yield Compensatory Response in Barley Cultivars Exposed to Wheat Stem Sawfly (Hymenoptera: Cephidae) Under Field Conditions
Authors: Achhami Buddhi B , Reddy Gadi V P , Sherman Jamie D , Peterson Robert K D , Weaver David K 
Published: August 2020

AbstractWheat stem sawfly, Cephus cinctus Norton, is an economically serious pest of cereals grown in North America. Barley cultivars were previously planted as resistant crops in rotations to manage C. cinctus, but due to increasing levels of injury to this crop, this is no longer a valid management tactic in Montana. Therefore, we aimed to understand antixenosis (behavioral preference), antibiosis (mortality), and potential yield compensation (increased productivity in response to stem injuries) in barley exposed to C. cinctus. We examined these traits in eight barley cultivars. Antixenosis was assessed by counting number of eggs per stem and antibiosis was assessed by counting infested stems, dead larvae, and stems cut by mature larvae. Potential yield compensation was evaluated by comparing grain yield from three categories of stem infestation: 1) uninfested, 2) infested with dead larva, and 3) infested cut by mature larva at crop maturity. We found the greatest number of eggs per infested stem (1.80 ± 0.04), the highest proportion of infested stems (0.63 ± 0.01), and the highest proportion of cut stems (0.33 ± 0.01) in ‘Hockett’. Seven out of eight cultivars had greater grain weight for infested stems than for uninfested stems. These cultivars may have compensatory responses to larval feeding injury. Overall, these barley cultivars contain varying levels of antixenosis, antibiosis, and differing levels of yield compensation. Our results provide foundational knowledge on barley traits that will provide a framework to further develop C. cinctus resistant or tolerant barley cultivars.
The effects of PSA kinetics on the outcome of hypofractionated salvage radiotherapy for biochemical recurrence of prostate cancer after prostatectomy
Authors: Ishikawa Hitoshi , Higuchi Keiko , Kaminuma Takuya , Takezawa Yutaka , Saito Yoshitaka , Etsunaga Toru , Maruo Kazushi , Kawamura Hidemasa , Kubo Nobuteru , Nakano Takashi , Kobayashi Mikio 
Published: August 2020

Abstract
The feasibility and efficacy of hypofractionated salvage radiotherapy (HS-RT) for prostate cancer (PC) with biochemical recurrence (BR) after prostatectomy, and the usefulness of prostate-specific antigen (PSA) kinetics as a predictor of BR, were evaluated in 38 patients who received HS-RT without androgen deprivation therapy between May 2009 and January 2017. Their median age, PSA level and PSA doubling time (PSA-DT) at the start of HS-RT were 68 (53–74) years, 0.28 (0.20–0.79) ng/ml and 7.7 (2.3–38.5) months, respectively. A total dose of 60 Gy in 20 fractions (three times a week) was three-dimensionally delivered to the prostate bed. After a median follow-up of 62 (30–100) months, 19 (50%) patients developed a second BR after HS-RT, but only 1 patient died before the last follow-up. The 5-year overall survival and BR-free survival rates were 97.1 and 47.4%, respectively. Late grade 2 gastrointestinal and genitourinary morbidities were observed in 0 and 5 (13%) patients, respectively. The PSA level as well as pathological T-stage and surgical margin status were regarded as significant predictive factors for a second BR by multivariate analysis. BR developed within 6 months after HS-RT in 11 (85%) of 13 patients with a PSA-DT &lt; 10 months compared with 1 (17%) of 6 with a PSA-DT ≥ 10 months (median time to BR: 3 vs 14 months, P &lt; 0.05). Despite the small number of patients, our HS-RT protocol seems feasible, and PSA kinetics may be useful for predicting the risk of BR and determining the appropriate follow-up schedule.
A Survey of Glaucoma Surgery Practice Patterns in the Veterans Health Administration
Authors: Olivieri Daniel J , Lynch Mary G , Cockerham Glenn C , Greenberg Paul B 
Published: August 2020

Abstract

Introduction
Glaucoma surgical practice patterns are not well described in the United States (US). This study aims to evaluate the indications for and potential barriers to glaucoma surgery in the Veterans Health Administration (VHA).

Materials and Methods
An anonymous 10-question survey using REDCap (Nashville, TN) software was sent by mail (with web link) and email to ophthalmology chiefs at the 86 academically affiliated Veterans Affairs Medical Centers (VAMCs). Academic-affiliated VAMCs were selected because of their patient range and role in ophthalmic education. Non-responders received two reminder e-mails and two phone calls; the survey was closed after 6 weeks. The data were analyzed using descriptive statistics.

Results
The response rate was 45% (39/86). Most respondents (92%) worked in an integrated eye clinic with both ophthalmology and optometry services. Almost half of the respondents (49%; 19/39) believed that laser trabeculoplasty (LTP) was an option for initial glaucoma therapy. Noncompliance was a commonly reported indication for LTP (95%), tube shunt procedures (65%), micro-invasive glaucoma surgery (59%), and trabeculectomy (48.7%). One third of the respondents believed that there were delays in glaucoma care. The respondents noted that significant barriers in access to surgery included lack of transportation (69%), scheduling challenges (62%), and delayed referral (62%).

Conclusion
This survey of glaucoma surgery practice patterns highlights the growing role of LTP and suggests that non-compliance and access remain significant barriers to glaucoma surgical care within the VHA.
Single-cell transcriptomic landscape of human blood cells
Authors: Xie Xiaowei , Liu Mengyao , Zhang Yawen , Wang Bingrui , Zhu Caiying , Wang Chenchen , Li Qing , Huo Yingying , Guo Jiaojiao , Xu Changlu , Hu Linping , Pang Aiming , Ma Shihui , Wang Lina , Cao Wenbin , Chen Shulian , Li Qiuling , Zhang Sudong , Zhao Xueying , Zhou Wen , Luo Hongbo , Zheng Guoguang , Jiang Erlie , Feng Sizhou , Chen Lixiang , Shi Lihong , Cheng Hui , Hao Sha , Zhu Ping , Cheng Tao 
Published: August 2020

Abstract
High throughput single-cell RNA-seq has been successfully implemented to dissect the cellular and molecular features underlying hematopoiesis. However, an elaborate and comprehensive transcriptome reference of the whole blood system is lacking. Here, we profiled the transcriptomes of 7551 human blood cells representing 32 immunophenotypic cell types, including hematopoietic stem cells, progenitors and mature blood cells derived from 21 healthy donors. With high sequencing depth and coverage, we constructed a single-cell transcriptional atlas of blood cells (ABC) on the basis of both protein-coding genes and long noncoding RNAs (lncRNAs), and showed a high consistence between them. Notably, putative lncRNAs and transcription factors regulating hematopoietic cell differentiation were identified. While common transcription factor regulatory networks were activated in neutrophils and monocytes, lymphoid cells dramatically changed their regulatory networks during differentiation. Furthermore, we showed a subset of nucleated erythrocytes actively expressing immune signals, suggesting the existence of erythroid precursors with immune functions. Finally, a web portal offering transcriptome browsing and blood cell type prediction has been established. Thus, our work provides a transcriptional map of human blood cells at single-cell resolution, thereby offering a comprehensive reference for the exploration of physiological and pathological hematopoiesis.
An Adherence-Enhancing Program Increases Retention in Care in the Swiss HIV Cohort
Authors: Kamal Susan , Glass Tracy R , Doco-Lecompte Thanh , Locher Sophie , Bugnon Olivier , Parienti Jean-Jacques , Cavassini Matthias , Schneider Marie P 
Published: August 2020

Abstract

Background
This study tested a theory-based adherence-enhancing intervention: the “Interprofessional Medication Adherence Program” (IMAP) to increase human immunodeficiency virus (HIV) retention in care.

Methods
We retrospectively compared our intervention center (intervention group [IG]) with a standard of care center (control group [CG]) both participating in the Swiss HIV Cohort Study between 2004 and 2012. Endpoints were defined as &gt;6-month and &gt;12-month gaps in care for intervals of care longer than 6 and 12 months without any blood draw. Inverse probability of treatment weights was used to adjust for differences between patients at the 2 centers. Viral failure was defined as ribonucleic acid ≥50 copies/mL after 24+ weeks on antiretrovirals.

Results
The IG included 451 patients, CG 311. In the IG, 179 (40%) patients took part in the IMAP for a median of 27 months (interquartile range, 12–45). Gaps in care of ≥6 months were significantly more likely to happen in the CG versus IG (74.6% vs 57%, P &lt; .001). The median time until the first treatment gap was longer in the IG vs CG (120 vs 84 weeks, P &lt; .001). Gaps in care of ≥12 months evaluated in 709 (93%) patients were significantly more likely to occur in the CG compared with the IG (22.6% vs 12.5%, P &lt; .001). The rate of viral failure was significantly lower in the IG (8.3% vs 15.1%, P = .003).

Conclusions
This study, in a real-world setting, shows the effectiveness of the IMAP to reduce 6- and 12-month gaps in follow up among people with HIV. These results should be confirmed by studies in other settings.
Efficacy and Safety of Switching to Dolutegravir With Boosted Darunavir in Virologically Suppressed Adults With HIV-1: A Randomized, Open-Label, Multicenter, Phase 3, Noninferiority Trial: The DUALIS Study
Authors: Spinner Christoph D , Kümmerle Tim , Schneider Jochen , Cordes Christiane , Heiken Hans , Stellbrink Hans-Jürgen , Krznaric Ivanka , Scholten Stephan , Jensen Björn , Wyen Christoph , Viehweger Marin , Lehmann Clara , Sprinzl Martin , Stoehr Albrecht , Bickel Markus , Jessen Heiko , Obst Wilfried , Spornraft-Ragaller Petra , Khaykin Pavel , Wolf Eva , Boesecke Christoph ,   DUALIS Study Group, Spinner Christoph D , Jensen Björn , Lutz Thomas , Spornraft-Ragaller Petra , Stellbrink  , Hower Martin , Bohr Ulrich , Obst Wilfried , Krznaric Ivanka , Sprinzl Martin , Audebert Franz , Kuemmerle Tim , Scholten Stefan , Hillenbrand Heribert , Cordes Christiane , Knechten Heribert , Kuhlmann Birger , Jessen Heiko , Beck Patrick , Fätkenheuer Gerd , Klinker Hartwig H F , Rockstroh Juergen K , Esser Stefan , Stephan Christoph , Degen Olaf , Bellmunt-Zschäpe Andreas , Khaykin Pavel , Brockmeyer Norbert , Stoehr Albrecht 
Published: August 2020

Abstract

Background
Dolutegravir (DTG) and boosted darunavir (bDRV) are potent antiretrovirals with a high resistance barrier and might be valuable switch options for people with HIV (PWH).

Methods
DUALIS, a randomized, open-label, phase 3b, noninferiority clinical trial, compared the switch to DTG + bDRV (2DR) with continuation of 2 nucleoside reverse transcriptase inhibitors (2NRTI) + bDRV (3DR). PWH with HIV RNA &lt;50 copies/mL taking 2NRTI + bDRV (3DR) for ≥24 weeks (1 accepted blip &lt;200 copies/mL) were randomized to either switch to DTG 50 mg + DRV 800 mg (boosted with 100 mg of ritonavir) or continue taking 3DR. The primary end point (PE) was the proportion of HIV RNA &lt;50 copies/mL at week (W) 48. Change in NRTI backbone was not classified as failure. The estimated sample size for PE analysis was 292; the noninferiority margin was ≤–10.0%.

Results
In total, 263 subjects were randomized and treated (2DR n = 131, 3DR n = 132; 90.1% male; 89.7% Caucasian; median age [interquartile range], 48 [39–54] years). At W48, 86.3% (n = 113/131) of the 2DR subject and 87.9% (n = 116/132) of the 3DR subjects had HIV RNA &lt;50 copies/mL; the difference between arms was –1.6% (95.48% CI, based on the adjusted alpha level accounting for the interim analysis at W24, –9.9% to +6.7%; discontinuations due to adverse events: 2DR, 4.6% [n = 6]; 3DR, 0.8% [n = 1]). Kaplan-Meier estimates of confirmed HIV RNA ≥50 copies/mL at W48 were 1.6% (n = 2) in the 2DR and 3.1% (n = 4) in the 3DR group. Development of treatment-emergent resistance was not observed.

Conclusions
Switching to DTG + bDRV was noninferior to continuing 3DR in subjects already treated with bDRV.
FOREST unbiased Galactic plane imaging survey with the Nobeyama 45 m telescope (FUGIN). VIII. Possible evidence of cloud–cloud collisions triggering high-mass star formation in the giant molecular cloud M 16 (Eagle Nebula)
Authors: Nishimura Atsushi , Fujita Shinji , Kohno Mikito , Tsutsumi Daichi , Minamidani Tetsuhiro , Torii Kazufumi , Umemoto Tomofumi , Matsuo Mitsuhiro , Tsuda Yuya , Kuriki Mika , Kuno Nario , Sano Hidetoshi , Yamamoto Hiroaki , Tachihara Kengo , Fukui Yasuo 
Published: August 2020

AbstractM 16, the Eagle Nebula, is an outstanding H ii region which exhibits extensive high-mass star formation and hosts remarkable “pillars.” We herein obtained new 12COJ = 1–0 data for the region observed with NANTEN2, which were combined with the 12COJ = 1–0 data obtained using the FOREST unbiased galactic plane imaging with Nobeyama 45 m telescope (FUGIN) survey. These observations revealed that a giant molecular cloud (GMC) of ∼1.3 × 105 M⊙ is associated with M 16, which extends for 30 pc perpendicularly to the galactic plane, at a distance of 1.8 kpc. This GMC can be divided into the northern (N) cloud, the eastern (E) filament, the southeastern (SE) cloud, the southeastern (SE) filament, and the southern (S) cloud. We also found two velocity components (blueshifted and redshifted components) in the N cloud. The blueshifted component shows a ring-like structure, and the redshifted one coincides with the intensity depression of the ring-like structure. The position–velocity diagram of the components showed a V-shaped velocity feature. The spatial and velocity structures of the cloud indicated that two different velocity components collided with each other at a relative velocity of 11.6 km s−1. The timescale of the collision was estimated to be ∼4 × 105 yr. The collision event reasonably explains the formation of the O9V star ALS 15348, as well as the shape of the Spitzer bubble N19. A similar velocity structure was found in the SE cloud, which is associated with the O7.5V star HD 168504. In addition, the complementary distributions of the two velocity components found in the entire GMC suggested that the collision event occurred globally. On the basis of the above results, we herein propose a hypothesis that the collision between the two components occurred sequentially over the last several 106 yr and triggered the formation of O-type stars in the NGC 6611 cluster in M 16.