bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pattern and Timing of Diversification in the African Freshwater Fish Genus Distichodus (Characiformes: Distichodontidae)
Authors: Arroyave Jairo , Denton John S. S. , Stiassny Melanie L. J. 
Published: April 2020

Abstract
Background : Distichodus is a clade of tropical freshwater fishes currently comprising 25 named species distributed continent-wide throughout the Nilo-Sudan and most Sub-Saharan drainages. This study investigates the phylogenetic relationships, timing of diversification, and biogeographic history of the genus from a taxonomically comprehensive mutilocus dataset analyzed using Maximum Likelihood and Bayesian methods of phylogenetic inference, coalescence-based species-tree estimation, divergence time estimation, and inference of geographic range evolution. Results: Analyses of comparative DNA sequence data in a phylogenetic context reveal the existence of two major clades of similar species-level diversity and provide support for the monophyletic status of most sampled species. Biogeographic reconstruction on a time-scaled phylogeny suggest that the origins of the genus date back to the late Oligocene and that current geographic distributions are the result of a Congo Basin origin followed by dispersal and range expansion into adjacent ichthyofaunal provinces at different times during the evolutionary history of the group. Conclusions : We present the most comprehensive phylogenetic, chronological, and biogeographic treatment yet conducted for the genus. The few instances of species paraphyly ( D. teugelsi, D. fasciolatus ) revealed by the resulting phylogenies are likely a consequence of post-divergence introgressive hybridization and/or incomplete lineage sorting due to recent speciation. Historical biogeographic findings are both in agreement and conflict with previous studies of other continent-wide African freshwater fish genera, suggesting a complex scenario for the assemblage of Africa’s continental ichthyofaunal communities.
Association between rural-to-urban migration and the cognitive aging trajectories of older Chinese adults: results from a prospective cohort analysis
Authors: Xie Jinzhao , Liao Jing , Zhang Jing , Gu Jing 
Published: April 2020

Abstract
Background: Increasingly, older Chinese adults from rural areas are moving to urban areas to live with their children who have already migrated to these areas. However, few studies have examined this pattern of migration and its effects on cognitive function. We aimed to investigate the association between domestic rural-to-urban migration and the trajectories of cognitive function in older Chinese adults, as well as the factors contributing to these association.Methods: Data for this study were drawn from three waves of the China Health and Retirement Longitudinal Study. Migrants were defined as participants who had rural hukou status (under China’s household registration system) but resided in an urban area. Cognitive functions were measured using an adapted Chinese version of the Mini-Mental State Examination. We used multilevel linear regression models to examine the association between internal migration and cognitive function trajectories.Results: The study included 3,876 Chinese adults aged ≥60 years at baseline. Compared with their rural non-migrant counterparts, migrants (n = 850) had higher levels of education and reported more interactions with family. Additionally, female migrants were more likely to participate in leisure activities. All cognitive function scores declined over time, but no significant differences were observed in rates of cognitive decline between migrants and non-migrants, regardless of sex. Female migrants exhibited significantly better performance in terms of total cognition (b = 0.77, P < .001) and mental status (b =0.68, P < .001) than female non-migrants, whereas no inter-group difference was observed regarding memory (b = 0.09, P > .05). Among the male subjects, no significant differences in cognitive function levels were observed between migrants and non-migrants. A series of adjusted models revealed that psychosocial factors such as residing with children, caring for grandchildren, depression and participation in leisure activities partly explained the association between migration and cognition in women.Conclusions: Rural-to-urban migration was positively associated with cognitive functions only in women. However, this pattern did not affect the rate of cognitive decline in either sex. Our findings indicate that interventions are warranted to increase the cognitive functions of male migrants and rural non-migrating older adults.
Depression, anxiety, and associated factors in patients with diabetes: evidence from the Anxiety, Depression, and Personality Traits in Diabetes Mellitus (ADAPT-DM) study
Authors: Woon Sy-Cherng Luke , Sidi Hatta , Ravindran Arun , Gosse Paula Junggar , Mainland Roslyn Laurie , Kaunismaa Emily Samantha , Hatta Nurul Hazwani , Arnawati Puteri , Zulkifli Amelia Yasmin , Mustafa Norlaila , Abdullah Mohammad Farris Iman Leong Bin 
Published: April 2020

Abstract
Background: Depression and anxiety are common psychiatric complications affecting patients with diabetes mellitus. However, data on the prevalence of depression, anxiety, and associated factors among Malaysian diabetic patients is scarce. The Anxiety, Depression, and Personality Traits in Diabetes Mellitus (ADAPT-DM) study aimed to determine the prevalence of depression and anxiety, and their associated factors in the Malaysian diabetic population. Methods: This cross-sectional study recruited 300 diabetic patients via convenience sampling from the Endocrine outpatient clinic of Universiti Kebangsaan Malaysia Medical Centre, a tertiary referral healthcare facility in Kuala Lumpur. Socio-demographic characteristics and clinical history were obtained from each participant. The Generalised Anxiety Disorder-7 (GAD-7) was administered to assess anxiety symptoms, the Beck Depression Inventory (BDI) to assess depressive symptoms, the Big Five Inventory (BFI) to evaluate personality traits, and the World Health Organization Quality of Life-BREF (WHOQOL-BREF) to measure quality of life (QOL). Stepwise multiple logistic regression analyses were performed to determine the association between various factors, and depression and anxiety. Results: The prevalence of depression was 20% (n = 60) while anxiety was 9% (n = 27). Co-morbid depression (adjusted odds ratio [OR] = 9.89, 95% confidence interval [CI] = 2.63- 37.14, p = 0.001) and neuroticism (adjusted OR = 11.66, 95% CI= 2.69-50.47, p = 0.001) increased the odds of developing anxiety, while conscientiousness (adjusted OR = 0.45, 95% CI= 0.23-0.80, p = 0.004) and greater psychological-related QOL (adjusted OR = 0.47, 95% CI= 0.29-0.75, p = 0.002) were protective. Co-morbid anxiety (adjusted OR = 19.83, 95% CI = 5.63- 69.92, p < 0.001) increased the odds of depression, while older age (adjusted OR = 0.96, 95% CI = 0.93–0.98, p = 0.002), social relationship-related QOL (adjusted OR= 0.84, 95% CI = 0.71- .0.99, p= 0.047), and physical health-related QOL (adjusted OR = 0.69, 95% CI = 0.58-0.83, p < 0.001) were protective. Conclusions: The study findings signify the need to screen for co-morbid depression and anxiety, as well as personality traits and QOL, and to include psychosocial interventions when planning a multidisciplinary approach to managing diabetes.
Preoperative SCC-Ag as a predictive marker for the use of adjuvant chemotherapy in cervical squamous cell carcinoma with intermediate-risk factors
Authors: Guo Hong-tao , Bi Xue-han , Lei Ting , Lv Xiao , Yao Guang , Chen Yao , Liu Chang 
Published: April 2020

Abstract
Background : For cervical cancer patients whose tumors display a combination of intermediate risk factors, postoperative radiation with or without adjuvant chemotherapy is suggested for them. However, who should be administered with adjuvant chemotherapy is unknown. The current study was designed to explore the clinical value of squamous cell carcinoma antigen (SCC-Ag) in guiding the use of adjuvant chemotherapy in cervical cancer patients. Methods : A retrospective study of 301 cervical cancer patients treated by surgery and adjuvant treatment from March 2006 to March 2016 was performed. All patients were divided into two groups according to receiving adjuvant chemotherapy or not. Overall survival (OS), disease-free survival (DFS) were compare between patients who did and did not receive adjuvant radiotherapy. Multivariate analysis was employed to detect clinical factors associated with disease-free survival, local recurrence-free survival and distant metastasis-free survival. Results: For patients with high pre-treatment SCC-Ag level, DFS and OS in adjuvant chemo-radiotherapy group were higher than that in adjuvant radiotherapy group. Besides, the rates of distant metastasis were found lower in patients who did receive adjuvant chemotherapy than those who did not. For patients with low pre-treatment SCC-Ag level, the 5-year OS and DFS were similar between groups of adjuvant chemo-radiotherapy and adjuvant radiotherapy. Multivariable analysis indicated adjuvant chemotherapy was independent predictors of DFS and distant metastasis-free survival (DMFS) in patients with high SCC-Ag level. Conclusion: SCC-Ag can serve as an indication for the administration of adjuvant chemotherapy in cervical cancer patients.
Predictors of physical activity in older adults early in an emergency hospital admission: a prospective cohort study
Authors: Hartley Peter , Dewitt Amanda L , Forsyth Faye , Romero-Ortuno Roman , Deaton Christi 
Published: April 2020

Abstract
Background: Reduced mobility may be responsible for functional decline and acute sarcopenia in older hospitalised patients. The drivers of reduced in-hospital mobility are poorly understood, especially during the early phase of acute hospitalisation. We investigated predictors of in-hospital activity during a 24-hour period in the first 48 hours of hospital admission in older adults. Methods: This was a secondary analysis of a prospective repeated measures cohort study. Participants aged 75 years or older were recruited within the first 24 hours of admission. At recruitment, patients underwent a baseline assessment including measurements of pre-morbid functional mobility, cognition, frailty, falls efficacy, co-morbidity, acute illness severity, knee extension strength and grip strength, and consented to wear accelerometers to measure physical activity during the first 7 days (or until discharge if earlier). In-hospital physical activity was defined as the amount of upright time (standing or walking). To examine the predictors of physical activity, we limited the analysis to the first 24 hours of recording to maximise the sample size as due to discharge from hospital there was daily attrition. We used a best subset analysis including all baseline measures. The optimal model was defined by having the lowest Bayesian information criterion in the best-subset analyses. The model specified a maximum of 5 covariates and used an exhaustive search.Results: Seventy participants were recruited but eight were excluded from the final analysis due to lack of accelerometer data within the first 24 hours after recruitment. Patients spent a median of 0.50 hours (IQR: 0.21; 1.43) standing or walking. The optimal model selected the following covariates: functional mobility as measured by the de Morton Mobility Index and two measures of illness severity, the National Early Warning Score, and serum C-reactive protein.Conclusions: Physical activity, particularly in the acute phase of hospitalisation, is very low in older adults. The association between illness severity and physical activity may be explained by symptoms of acute illness being barriers to activity. Interdisciplinary approaches are required to identify early mobilisation opportunities.
A Proposed Severity Classification of Borderline Symptoms Using the Borderline Symptom List (BSL-23)
Authors: Kleindienst Nikolaus , Jungkunz Martin , Bohus Martin 
Published: April 2020

Abstract
Background The Borderline Symptom List (BSL-23) is a well-established self-rating instrument to assess the severity of borderline typical psychopathology. However, a classification of severity levels for the BSL-23 is missing. Methods Data from 1.090 adults were used to develop a severity classification for the Borderline Symptom List (BSL-23). The severity grading was based on the distribution of the BSL-23 in 241 individuals with a diagnosis of BPD. Data from three independent samples were used to validate the previously defined severity grades. These validation samples included a group of treatment seeking patients with a diagnosis of BPD (n=317), a sample of individuals with mental illnesses other than BPD (n=176), and a healthy control sample (n=356). The severity grades were validated from comparisons with established assessment instruments such as the International Personality Disorders Examination, the Structured Clinical Interview for DSM-IV, the global severity index of the Symptom Checklist (GSI, SCL-90), the Global Assessment of Functioning (GAF), and the Beck Depression Inventory (BDI-II).Results Six grades of symptom severity were defined for the BSL-23 mean score: none or low: 0-0.3; mild: 0.3-0.7; moderate: 0.7-1.7; high: 1.7-2.7; very high: 2.7-3.5; and extremely high: 3.5-4. These grades received consistent empirical support from the independent instruments and samples. For instance, individuals with a severity grade of none or low were virtually free from diagnostic BPD-criteria, had a GSI below the normative population, and a high level of global functioning corresponding to few or no symptoms. Severity grades indicating high to extremely high levels of BPD symptoms were observed at a much higher rate in treatment-seeking patients (70.0%) than in clinical controls (17.6%) and healthy controls (0.0%). The BSL-23 score that best separated treatment-seeking BPD patients and clinical controls was 1.50, whereas the clearest discrimination of BPD patients and healthy controls was found at a score of 0.64.Conclusions The grades of BPD-specific symptom severity derived from the distribution of the BSL-23 scores received consistent empirical validation from established assessments for psychopathology. Future studies should expand this validation by including additional instruments e.g., to assess self-esteem, loneliness, connectedness, and quality of life.
Changes in community mental health services availability and suicide mortality in the US: A retrospective study
Authors: Hung Peiyin , Busch Susan , Shih Yi-Wen , McGregor Alecia , Wang Shi-Yi 
Published: April 2020

Abstract
Background: Despite the fact that the overwhelming majority of mental health services are delivered in outpatient settings, the effect of changes in non-hospital-based mental health care on increased suicide rates is largely unknown. This study examines the association between changes in community mental health center (CMHC) supply and suicide mortality in the United States.Methods: Retrospective analysis was performed using data from National Mental Health Services Survey (N-MHSS) and the Centers for Disease Control and Prevention (CDC) Wide-Ranging Online Data for Epidemiologic Research (WONDER) (2014-2017). Population-weighted multiple linear regressions were used to examine within-state associations between CMHCs per capita and suicide mortality. Models controlled for state-level characteristics (i.e., number of hospital psychiatric units per capita, number of mental health professionals per capita, age, race, and percent low-income), year and state.Results: From 2014 to 2017, the number of CMHCs decreased by 14% nationally (from 3,406 to 2,920). Suicide increased by 9.7% (from 15.4 to 16.9 per 100,000) in the same time period. We find a small but negative association between the number of CMHCs and suicide deaths (-0.52, 95% CI -1.08 to 0.03; p=0.066). Declines in the number of CMHCs from 2014 to 2017 may be associated with approximately 6% of the national increase in suicide, representing 263 additional suicide deaths. Conclusions: State governments should avoid the declining number of CMHCs and the services these facilities provide, which may be an important component of suicide prevention efforts.
Childhood Socioeconomic Status, Comorbidity of Chronic Kidney Disease Risk Factors, and Kidney Function Among Adults in the Midlife in the United States (MIDUS) Study
Authors: Surachman Agus , Daw Jonathan , Bray Bethany , Alexander Lacy , Coe Christopher , Almeida David M. 
Published: April 2020

Abstract
Background: There is a lack of empirical effort that systematically investigates the clustering of comorbidity among known risk factors (obesity, hypertension, diabetes, hypercholesterolemia, and elevated inflammation) of chronic kidney disease (CKD) and how different types of comorbidity may link differently to kidney function among healthy adult samples. This study modeled the clustering of comorbidity among risk factors, examined the association between the clustering of risk factors and kidney function, and tested whether the clustering of risk factors was associated with childhood SES.Methods: The data were from 2,118 participants (ages 25-84) in the Midlife in the United States (MIDUS) Study. Risk factors included obesity, elevated blood pressure (BP), high total cholesterol levels, poor glucose control, and increased inflammatory activity. Glomerular filtration rate (eGFR) was estimated from serum creatinine, calculated with the CKD-EPI formula. The clustering of comorbidity among risk factors and its association with kidney function and childhood SES were examined using latent class analysis (LCA).Results: A five-class model was optimal: (1) Low Risk (class size = 36.40%; low probability of all risk factors), (2) Obese (16.42%; high probability of large BMI and abdominally obese), (3) Obese and Elevated BP (13.37%; high probability of being obese and having elevated BP), (4) Non-Obese but Elevated BP (14.95%; high probability of having elevated BP, hypercholesterolemia, and elevated inflammation), and (5) High Risk (18.86%; high probability for all risk factors). Obesity was associated with kidney hyperfiltration, while comorbidity between obesity and hypertension was linked to compromised kidney filtration. As expected, the High Risk class showed the highest probability of having eGFR < 60 ml/min/1.73 m2 (P = .12; 95%CI = .09 - .17). Finally, low childhood SES, controlling for education, adult SES, age, gender, and race, was associated with a higher probability of being in the High Risk rather than the Low Risk class (b = -0.20, SE = 0.07, OR [95%CI] = 0.82 [0.71-0.95]).Conclusion: These results highlight the importance of considering the impact of childhood SES on risk factors known to be associated with chronic kidney disease.
COVID-19: Are you ready to seek psychological help during home quarantine?
Authors: Zhang Hui , Su Hong , Wang Dongxue , Wang Lining , Cai Yunjiang , Zhou Yuqiu 
Published: April 2020

Abstract
Background: Since December 2019, an increasing number of cases named Corona Virus Disease 2019 (COVID-19) have been identified in Wuhan, China. It has widely and rapidly spread in China and several other countries. The public experienced mental health problems during home quarantine.Methods：From Feb 17 to 20, 2020, a questionnaire star survey was used to evaluate the psychological distress / psychological help-seeking attitudes and behavior of 3,248 people over 18 years old who were quarantined at home, all the subjects filled out the questionnaires, including general information questionnaire, Kessler Psychological Distress Scale (K-10),Attitudes Toward Seeking Mental Health and Psychological help-seeking behavior items.Results:3,248 individuals were enrolled, and the score of psychological distress scale was 15·93±6·99, the score of psychological help seeking was 82·34 ±13·04. Among the socio-economic factors, age was positively associated with the psychological distress(t=5·60,P<0·05) and attitudes toward seeking mental health(t=-3·380,P<0·05); the level of income were negatively associated with psychological distress(t=-2·609,P<0·05) and attitudes toward seeking mental health(t=-2·762,P<0·05); occupation were negatively associated with the level of psychological distress(t=-2·842,P<0·05); gender and the level of education were positively associated with the level of attitudes toward seeking mental health(t=6·355,P<0·05;t=3·780,P<0·05); marital status were negatively associated with the level of attitudes toward seeking mental health(t=-3·455,P<0·05).Conclusions: Widowed, rural residents, people with low level of education and economic income should be the focus of COVID-19’s mental health maintenance, and making good use of media and internet tools to strengthen publicity is one of the key points of current prevention and control.
Reactional Ultrasonic Systems And Microwave Irradiation For Pretreatment Of Agro-Industrial Waste To Increase Enzymatic Activity
Authors: Czapela Fabiane Fernanda , Kubeneck Simone , Preczeski Karina Paula , Dalastra Caroline , Scapini Thamarys , Bonatto Charline , Stefanski Fábio Spitza , Camargo Aline Frumi , Zanivan Jessica , Mossi Altemir José , Fongaro Gislaine , Treichel Helen 
Published: April 2020

Abstract
Keratinous residues are generated in large quantities in industrial processes and because of this they are difficult to manage because the presence of keratin. Keratinases are emerging as promising alternatives in technological processes. The objective of this work was to determine the potential of pretreatment of agro-industrial residues using an ultrasonic probe, and to evaluate activity enhancement strategies by analyzing the behavior of enzymatic activity of keratinases exposed to various reaction systems as well as to enzymatic concentration. We tested the application of enzymatic extracts in the degradation of keratinous residues. Submerged fermentation was performed with swine hair pretreated with and without ultrasonic probe. The enzymatic extracts were exposed to reaction systems and the enzymatic concentration technique to measure the increments of enzymatic activity. We found that the ultrasonic probe increased reaction rates, enabling higher enzyme production in shorter time periods. The ultrasonic probe reached 38.4% of relative activity and the enzyme concentration, increased the enzymatic activity in 53.5%. We observed potential degradation of chicken feathers with homemade enzyme extracts. Taken together, our findings suggest that the results obtained in this work are promising, despite the fact that the data in this area are scarce.