bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and implementation DVB-S & DVB-S2 systems
Authors: Jasim Mohammed Samir , Saadi Hussein Zaid 
Published: September 2020

<p>Digital video broadcasting plays an important role in most digital communication systems. Digital broadcasting systems are designed with great accuracy and delicate design which has a major role in our lives today especially digital video broadcasting. It is these systems that are considered to be the most advanced in transmission, reception and reliability. From these systems they develop through the digital video broadcasting project group.The most important are digital video broadcasting of terrestrial, digital video broadcasting of cable and digital video broadcasting of satellite because of that many user's desires to use communications and entertainment in their lives there are new and demanding situations that the standards of these systems can only meet for their own applications .In this paper, it will design and implement the digital video broadcasting of satellite first generation and digital video broadcasting of satellite second generation of binary data,image and audio using Matlab-Simulink environment.In addition, will calculate the bit error rate of the signal. This system is designed with precision to improve performance errors and increase transmission capacity as well as provide a safe environment for information.</p>
Calculating algorithm of service quality statistical parameters for asynchronous network subscribers
Authors: Zhanar Satibaldievna Kemelbekova , O.Z Sembiyev , Zh.R Umarova 
Published: September 2020

It is often necessary to determine statistical parameters that characterize the quality of service on the network by managing when designing computer networks using the concept of virtual connections with bypass directions. In many ways, the attainable level of quality of the services provided is determined at the stage of network design, when decisions was made regarding the subscriber capacity of stations, the capacity of bundles of trunk lines, the composition and volume of telecommunication services provided. Despite constant progress in the field of network technologies, the problem of determining the necessary amount of network resources and ensuring the quality of user service remains relevant. In this regard, this article discusses a broadband digital network with service integration, based on an asynchronous network in which an iterative method implemented. Here the flow distribution is determined by the route matrix, and the load distribution between the nodes of each pair of nodes made through the path tree obtained on the matrix of routes when calculating this pair. At the same time, an algorithm has been built for allow optimal allocation of channel resources between circuit switching and packet switching subnets within an asynchronous network.
Best neural simultaneous approximation
Authors: Almurieb Hawraa Abbas , Bhaya Eman S. 
Published: September 2020

For many years, approximation concepts has been investigated in view of neural networks for the several applications of the two topics. Researchers studied simultaneous approximation in the 2-normed space and proved essential theorems concern with existence, uniqueness and degree of best approximation. Here, we define a new 2-norm in -space, with so we call it quasi 2- normed space ( ). The set of approximations is a space of feedforward neural networks that is constructed in this paper. Existence and uniqueness of best neural approximation for a function from is proved, describing the rate of best approximation in terms of modulus of smoothness.
An Important Role for DNMT3A-Mediated DNA Methylation in Cardiomyocyte Metabolism and Contractility
Authors: Madsen Alexandra , Höppner Grit , Krause Julia , Hirt Marc N. , Laufer Sandra D. , Schweizer Michaela , Tan Wilson Lek Wen , Mosqueira Diogo , Anene-Nzelu Chukwuemeka George , Lim Ives , Foo Roger S.Y. , Eschenhagen Thomas , Stenzig Justus 
Published: September 2020

Background:
DNA methylation acts as a mechanism of gene transcription regulation. It has recently gained attention as a possible therapeutic target in cardiac hypertrophy and heart failure. However, its exact role in cardiomyocytes remains controversial. Thus, we knocked out the main de novo DNA methyltransferase in cardiomyocytes, DNMT3A, in human induced pluripotent stem cells. Functional consequences of DNA methylation-deficiency under control and stress conditions were then assessed in human engineered heart tissue from knockout human induced pluripotent stem cell–derived cardiomyocytes.

Methods:

DNMT3A
was knocked out in human induced pluripotent stem cells by CRISPR/Cas9gene editing. Fibrin-based engineered heart tissue was generated from knockout and control human induced pluripotent stem cell–derived cardiomyocytes. Development and baseline contractility were analyzed by video-optical recording. Engineered heart tissue was subjected to different stress protocols, including serum starvation, serum variation, and restrictive feeding. Molecular, histological, and ultrastructural analyses were performed afterward.

Results:

Knockout of
DNMT3A
in human cardiomyocytes had three main consequences for cardiomyocyte morphology and function: (1) Gene expression changes of contractile proteins such as higher atrial gene expression and lower MYH7/MYH6 ratio correlated with different contraction kinetics in knockout versus wild-type; (2) Aberrant activation of the glucose/lipid metabolism regulator peroxisome proliferator-activated receptor gamma was associated with accumulation of lipid vacuoles within knockout cardiomyocytes; (3) Hypoxia-inducible factor 1α protein instability was associated with impaired glucose metabolism and lower glycolytic enzyme expression, rendering knockout-engineered heart tissue sensitive to metabolic stress such as serum withdrawal and restrictive feeding.

Conclusion:
The results suggest an important role of DNA methylation in the normal homeostasis of cardiomyocytes and during cardiac stress, which could make it an interesting target for cardiac therapy.
Possible Dependence of Climate on Atmospheric Mass: A Convection–Circulation–Cloud Coupled Feedback
Authors: Xiong Junyan , Yang Jun , Nie Ji 
Published: September 2020

AbstractThe total mass of the atmosphere [or equivalently, the background surface pressure (SP)] may have varied significantly over the evolutionary histories of Earth and other planets. Atmospheric mass can affect climate by modifying physical processes, including shortwave scattering, the emissivity of greenhouse gases, the atmospheric heat capacity, and surface fluxes. We apply a three-dimensional global climate model to explore the dependence of climate on SP over the range of 0.5–2.5 bar. Our simulations show an intriguing, nonmonotonic dependence of climate on SP. Over the SP range of 0.5–0.9 and 1.5–2.5 bar, the surface temperature increases with SP; however, over the SP range of 0.9–1.5 bar, the surface temperature decreases with SP. The negative correlation is due to a convection–circulation–cloud coupled feedback. As SP increases, the moist adiabatic lapse rate increases, leading to upper-troposphere cold anomalies in the tropics and middle latitudes that increase the midlatitude baroclinicity and eddy activity. In association with these changes, the eddy-driven jet is strengthened and shifts equatorward, and two separate westerly jets merge into a single jet. These abrupt circulation changes result in an equatorward shift of the midlatitude cloud belt and reduction of polar clouds, which induce strong negative cloud radiative forcing that cools the climate. Our results demonstrate that the regime transition of flow state (e.g., the merge of jets here) may induce large anomalies in clouds and radiative forcing, resulting in nonlinear climate responses.
Boundary Layer and Surface Verification of the High-Resolution Rapid Refresh, Version 3
Authors: Fovell Robert G. , Gallagher Alex 
Published: September 2020

AbstractWhile numerical weather prediction models have made considerable progress regarding forecast skill, less attention has been paid to the planetary boundary layer. This study leverages High-Resolution Rapid Refresh (HRRR) forecasts on native levels, 1-s radiosonde data, and (primarily airport) surface observations across the conterminous United States. We construct temporally and spatially averaged composites of wind speed and potential temperature in the lowest 1 km for selected months to identify systematic errors in both forecasts and observations in this critical layer. We find near-surface temperature and wind speed predictions to be skillful, although wind biases were negatively correlated with observed speed and temperature biases revealed a robust relationship with station elevation. Above ≈250 m above ground level, below which radiosonde wind data were apparently contaminated by processing, biases were small for wind speed and potential temperature at the analysis time (which incorporates sonde data) but became substantial by the 24-h forecast. Wind biases were positive through the layer for both 0000 and 1200 UTC, and morning potential temperature profiles were marked by excessively steep lapse rates that persisted across seasons and (again) exaggerated at higher elevation sites. While the source or cause of these systematic errors are not fully understood, this analysis highlights areas for potential model improvement and the need for a continued and accessible archive of the data that make analyses like this possible.
Assessing Increased Activities of the Forearm Muscles Due to Anti-Vibration Gloves: Construct Validity of a Refined Methodology
Authors: Yao Yumeng , Rakheja Subhash , Larivière Christian , Marcotte Pierre 
Published: September 2020

Objective The primary aim was to test the construct validity of a surface electromyography (EMG) measurement protocol, indirectly assessing the effects of anti-vibration (AV) gloves on activities of the forearm muscles. Background AV gloves impose a relatively higher grip demand and thus a higher risk for musculoskeletal disorders. Consequently, activities of the forearm muscles should be considered when assessing AV glove performance. Method Effects of AV gloves on activities of the forearm muscles (ECR: extensor carpi radialis longus; ED: extensor digitorum; FCR: flexor carpi radialis; FDS: flexor digitorum superficialis) were measured via EMG, while gripping a handle with two grip force levels. Fifteen subjects participated with 11 glove conditions, including one with bare hand. Results Activities of ECR, FCR, mean of ECR and FCR (ECR_FCR), and mean of all four muscles were sensitive to wearing gloves. Compared with bare hand, combined ECR_FCR activities increased by 22%–78% (mean = 48%, SD = 28%) with gloves. The correlation coefficient ( r) of ECR_FCR activities with glove thickness and manual dexterity scores were 0.74 ( p < .05) and 0.90 ( p < .001), respectively. Conclusions A refined EMG methodology was the most sensitive to AV gloves with specific forearm muscles (ECR and FCR) and the 50-N handgrip force. Its construct validity was further substantiated by correlations with glove thickness and manual dexterity. Application Assessment of the effect of AV gloves on activities of the forearm muscles can yield design guidance for AV gloves to reduce grip exertion by the gloved hand.
A comparative analysis of four activated clotting time measurement devices in cardiac surgery with cardiopulmonary bypass
Authors: Li Han , Serrick Cyril , Rao Vivek , Yip Paul M 
Published: September 2020

Background: In cardiac surgery on cardiopulmonary bypass (CPB), heparin anticoagulation is monitored by point-of-care measurement of activated clotting time (ACT). The objective of this study was to compare four ACT systems in cardiac surgery in terms of their reproducibility, agreement and potential clinical impact at relevant medical decision points. Methods: The study included 40 cardiac surgery patients. Samples were taken at five time points before (T1), after heparinization for CPB (T2, T3, T4), and after heparin reversal (T5). The reproducibility, correlation, and differences in ACT values were assessed with two devices from each of the four ACT systems: Instrumentation Laboratory Hemochron Elite (Hmch), Medtronic HMS Plus (HMS), Abbott i-STAT, and Helena Abrazo. Subrange analyses were performed for low ACT values (results from T1, T5) and high ACT values (results from T2, T3, T4). Results: Within-system analysis showed strong linear correlation between paired measurements (R = 0.968-0.993). However, Hmch showed poorer reproducibility with highest proportion of values that exceed a difference of 10% and highest overall standard error of 74 seconds across the measurement range compared to that of the others (range 39-47 seconds, respectively). For inter-system comparison, using Hmch as reference, ACTs were strongly correlated as follows: HMS (R = 0.938), i-STAT (R = 0.911), and Abrazo (R = 0.911). Agreement analysis in the high ACT range showed HMS tended to have higher ACT values with +11% bias over Hmch, whereas i-STAT (–8% bias) and Abrazo (–13% bias) tended to underestimate. Post-protamine ACT results were dependent on device type where Hmch yielded highest post-protamine ACT (+13% higher than baseline) compared to –16% for HMS, –10% for iSTAT and 0% for Abrazo. Conclusions: Each device had individual reproducibility and biases, which may impact peri-operative heparin management. Careful validation must be undertaken when adopting a different method as decision limits would be affected. Clinicians should also be cautious using ACT as the only indicator for full heparin reversal.
Anti-PD-1, anti-VEGF, and temozolomide therapy in a patient with recurrent glioblastoma: a case report
Authors: Chen Can , Zuo Wenwei , Yang Pan , Zhang Yanling 
Published: September 2020

Background Patients suffering from postoperative recurrent glioblastoma have an extremely unfavorable outcome because there are no proven therapeutic options. The median overall survival for those with relapsed glioblastoma after surgery is only 7.5 months. Case presentation: Between March 2015 and October 2019, a 44-year-old female patient with recurrent glioblastoma was treated by our medical team. After several failed rounds of therapy, the patient was subsequently treated with the anti-programmed death (PD)-1 antibody nivolumab, anti-vascular endothelial growth factor (VEGF) antibody bevacizumab, and cytotoxic agent temozolomide. Results The patient showed a sustainable complete response to the regimen. To date, there have been no serious toxic side effects. As of October 2019 (the last follow-up), the patient has been in complete remission for 17 months since recurrence. Conclusion The experience of this complicated case indicates the possible application of immune checkpoint inhibitors, anti-angiogenesis agents, and cytotoxic reagents for recurrent glioblastoma. The administration of this three-agent regimen appears safe and effective. However, further clinical trials are warranted.
Effect of Dexmedetomidine on Delirium in Elderly Surgical Patients: A Meta-analysis of Randomized Controlled Trials
Authors: Lin Chunmei , Tu Hankun , Jie Zhixuan , Zhou Xinkai , Li Chaoyang 
Published: September 2020

Objective: The purpose of this meta-analysis is to assess the effect of dexmedetomidine on delirium in elderly surgical patients. Data Sources: The Cochrane Library, Web of Science, PubMed, EMBASE, and Google Scholar were searched (January 1, 2000, to February 4, 2020) for randomized controlled trials (RCTs). Study Selection and Data Extraction: RCTs without language restrictions were included if delirium incidence was assessed in elderly surgical patients receiving dexmedetomidine. Intervention and basic information were extracted. Data Synthesis: 21 studies were included. Dexmedetomidine reduced delirium occurrence (risk ratio [RR] = 0.55; 95% CI = 0.45 to 0.67) in elderly surgical patients with sufficient evidence from trial sequential analysis. Dexmedetomidine did not prevent delirium incidence for cardiac surgery (RR = 0.71; 95% CI = 0.44 to 1.15) with insufficient evidence. Dexmedetomidine decreased mortality incidence (RR = 0.47; 95% CI = 0.25 to 0.89), shortened the length of intensive care unit (ICU; standard mean difference [SMD] = −0.46) and hospital stays (SMD = −0.41), and increased bradycardia incidence (RR = 1.60). Relevance to Patient Care and Clinical Practice: This review revealed that dexmedetomidine could reduce delirium incidence for elderly noncardiac surgical patients, and the effect of dexmedetomidine on delirium for elderly cardiac surgical patients needs further studies to guide clinicians. Conclusion: Dexmedetomidine reduced delirium incidence in elderly surgical patients. The efficacy of dexmedetomidine on delirium for elderly cardiac surgical patients warrants further studies. Furthermore, dexmedetomidine was associated with an increased bradycardia incidence, shorter length of ICU/hospital stays, and a lower incidence of mortality.
Labor-force participation and working patterns among women and men who have survived cancer: A descriptive 9-year longitudinal cohort study
Authors: Brusletto Birgit , Nielsen Roy A. , Engan Harald , Oldervoll Line , Ihlebæk Camilla M. , Mjøsund Nina Helen , Torp Steffen 
Published: September 2020

Aims: Our aim was to investigate labor-force participation, working hours, job changes, and education over 9 years among persons who have survived more than 10 years after cancer, and compare it to controls. Methods: Register data on 2629 persons who survived cancer were stratified by gender and compared to data on 5258 matched controls. Persons who survived cancer were aged 30–50 when diagnosed with cancer and had a work contract prior to diagnosis. Descriptive analysis and t-tests were performed. Results: The proportion of female persons who survived cancer in the labor force was reduced from 100% to 83.9% during follow-up, demonstrating a significant difference compared to controls for each year measured. The proportion of male persons who survived cancer dropped from 100% to 84.8%, but was only significantly different compared to controls in 2 years. The proportion of female persons who had survived cancer who worked full-time was lower in all years compared to both controls and male persons who survived cancer; in turn, male persons who had survived cancer worked full-time less than male controls. The proportion of female persons who had survived cancer who worked less than 20 hours per week increased compared to controls. The frequency of change of employer was higher among female persons who survived cancer compared to controls for some years, but no significant differences between male persons who survived cancer and controls were found. Female persons who survived cancer were in education more often than male persons who survived cancer. Conclusions: Persons who survived cancer experienced reduced labor-force participation and working hours 9 years after diagnosis, and the reduction was more pronounced for women than for men. Working patterns were also different between genders and between persons who survived cancer and controls.
Symptoms and Clinical Findings in Primary Headache Syndrome Versus Chronic Rhinosinusitis
Authors: Sharbel Daniel D. , Owen Harry C. , Yelverton Joshua C. , Li Mingsi , Holmes Thomas , Kountakis Stilianos E. 
Published: September 2020

Background Primary headache syndrome (PHS) patients frequently present to otolaryngologists with sinonasal complaints and diagnosis of chronic rhinosinusitis (CRS) due to symptomatic overlap. In this study, we compare demographic, subjective, and objective clinical findings of patients with PHS versus CRS. Methods We retrospectively reviewed a database of patients presenting to a single tertiary care Rhinology clinic from December 2011—July 2017. Sino-Nasal Outcome Test-22 (SNOT) scores and Lund-Kennedy endoscopy scores were obtained. Lund-MacKay CT scores were calculated, if available. Requirement of headache specialist management was compared between PHS and CRS groups. Patients with both CRS and PHS (CRScPHS) that required headache specialist management were compared to patients with CRS without PHS (CRSsPHS) and patients with PHS alone using Kruskal-Wallis analysis of variance. Receiver operating characteristic (ROC) analyses were carried out to determine significant diagnostic thresholds. Results One-hundred four PHS patients and 130 CRS patients were included. PHS patients (72.1%) were more likely than CRS patients to require headache specialist management (6.9%, p<0.0001). CRSsPHS patients had significantly higher Nasal domain scores compared to PHS patients ( p = 0.042) but not compared to CRScPHS patients ( p>0.99). CRScPHS ( p = 0.0003) and PHS ( p<0.0001) subgroups of patients had significantly higher Aural/Facial domain scores compared to CRSsPHS patients. PHS patients also had significantly higher Sleep domains scores compared to CRSsPHS patients ( p<0.0001). Both CRScPHS and CRSsPHS subgroups had significantly higher nasal endoscopy scores ( p<0.0001) and CT scores ( p = 0.04 & p<0.0001, respectively) compared to the PHS group. Aural/Facial domain score of 4, nasal endoscopy score of 4, and CT score of 2 were found to be reliable diagnostic thresholds for absence of CRS. Conclusions The SNOT-22 may be used to distinguish PHS from CRS based upon the Aural/Facial and Sleep domains. Patients with CRS have more severe Nasal domain scores and worse objective endoscopy and CT findings.
Diabetes patient’s pharmacovigilance knowledge and risk perception: the influence of being part of a patient organisation
Authors: Matos Cristiano , van Hunsel Florence , Tavares Ribeiro Rogério , Nascimento do Ó Dulce , Raposo João Filipe 
Published: September 2020

Objective: The aim was to assess the perception of risk for developing adverse drug reaction (ADRs) and knowledge, attitudes and opinions regarding pharmacovigilance in diabetic patients, and to investigate the effect of being a member of a patient organisation for diabetes on these factors, in comparison with other patients. Methods: A cross-sectional study looking for patients’ risk perception of experiencing ADRs. Diabetes patients followed at the Portuguese Diabetes Association (APDP) were included, together with two comparison groups (patients with and without diabetes). Kruskal-Wallis followed by post hoc Dunn’s multiple-comparison test were used to compare patients’ groups. Results: A total of 314 patients participated in the survey (104 followed at APDP, 106 with diabetes not followed at APDP and 104 without diabetes diagnosis that used chronic medication). APDP patients presented higher risk perception scores for medicines related to their disease compared with two groups. Those patients affirmed that doctors explained possible ADRs on medication to them, and showed higher intention to report ADRs in the future if serious or unexpected. Conclusions: Patients with diabetes showed greater understanding of ADRs and higher need to report them than patients without diabetes. They would like to have more information about general ADRs related to anti-diabetic medication and present higher intention to acquire information on how and when to report compared with non-diabetic patients. Patients followed in APDP presented higher score of risk perception, which could be influenced by the presence of the diabetes disease in the patients’ life, by their previous experiences using medicines, but also by information received from the patient organisation. The two groups of patients with diabetes have different experiences of the disease, but both present higher perception of side effects related with medicines they use respectively in their diabetes type. Hence, patient organisations are well positioned to be a source where patients can obtain reliable information, changing their attitudes and perceptions about the disease and drug treatments.