bluuebunny/crossref_metadata_2025_split huggingface dataset:
Repellency of forty‐one aromatic plant species to the Asian citrus psyllid, vector of the bacterium associated with huanglongbing
Authors: Yan Zhaogui , Zhang Qun , Zhang Nan , Li Wan , Chang Cuiying , Xiang Yan , Xia Changxiu , Jiang Tengyu , He Wei , Luo Jie , Xu Yongrong 
Published: November 2020

AbstractHuanglongbing (HLB) is the most devastating citrus disease worldwide. The organism associated with the disease is spread by an insect vector, Diaphorina citri, commonly known as Asian citrus psyllid (ACP). Current management of HLB relies either on physical removal of the infected plants or on chemical control of ACP. Both methods are costly and not overly effective. In addition, public concerns regarding insecticide residues in fruit have greatly increased in recent years. It has been hypothesized that plant volatiles could act as repellents to ACP, thus reduce the incidence of HLB. To test this hypothesis, the repellency of fresh tissues of 41 aromatic plant species to ACP was investigated. The repellency of individual species was determined using a Y‐tube olfactometer. Our results showed that volatiles of five plant species were highly effective in repelling ACP with repellency as much as 76%. Among these, the tree species, Camptotheca acuminate, and the two shrubs, Lantana camara and Mimosa bimucronata, could potentially be planted as a landscape barrier. The two herbs, Capsicum annuum and Gynura bicolor, could potentially be used as interplantings in orchards. This is the first time that the repellency of fresh tissues from a diverse range of plant species to ACP has been determined. Although further field evaluation of various interplanting regimes and landscape barriers are needed to assess their effectiveness, our results showed that these aromatic species, being highly repellent to ACP, offer great potential as more cost‐effective and environmentally sustainable alternatives to the current methods of managing HLB.
Modeling the effects of grassland management intensity on biodiversity
Authors: Klein Noëlle , Theux Coralie , Arlettaz Raphaël , Jacot Alain , Pradervand Jean‐Nicolas 
Published: November 2020

AbstractA growing food demand and advanced agricultural techniques increasingly affect farmland ecosystems, threatening invertebrate populations with cascading effects along the food chain upon insectivorous vertebrates. Supporting farmland biodiversity thus optimally requires the delineation of species hotspots at multiple trophic levels to prioritize conservation management. The goal of this study was to investigate the links between grassland management intensity and orthopteran density at the field scale and to upscale this information to the landscape in order to guide management action at landscape scale. More specifically, we investigated the relationships between grassland management intensity, floral indicator species, and orthopteran abundance in grasslands with different land use in the SW Swiss Alps. Field vegetation surveys of indicator plant species were used to generate a management intensity proxy, to which field assessments of orthopterans were related. Orthopteran abundance showed a hump‐shaped response to management intensity, with low values in intensified, nutrient‐rich grasslands and in nutrient‐poor, xeric grasslands, while it peaked in middle‐intensity grasslands. Combined with remote‐sensed data about grassland gross primary productivity, the above proxy was used to build landscape‐wide, spatially explicit projections of the potential distribution of orthopteran‐rich grasslands as possible foraging grounds for insectivorous vertebrates. This spatially explicit multitrophic approach enables the delineation of focal farmland areas in order to prioritize conservation action.
Protective behavior or ‘true’ tool use? Scrutinizing the tool use behavior of ants
Authors: Módra Gábor , Maák István , Lőrincz Ádám , Juhász Orsolya , Kiss Péter János , Lőrinczi Gábor 
Published: November 2020

AbstractIn the genus Aphaenogaster, workers use tools to transport liquid food to the colony. During this behavior, ants place or drop various kinds of debris into liquids or soft food, and then, they carry the food‐soaked tools back to the nest. According to some authors, this behavior is not "true" tool use because it represents two separate processes: a defense response to cover the dangerous liquid and a transport of food. Here, we investigated the debris dropping and retrieving behavior of the ant Aphaenogaster subterranea to establish which of the two hypotheses is more probable by conducting manipulative experiments. We tested the responses of eight colonies (a) to liquid food (honey‐water) and nonfood liquids (water) in different distances from the nest and (b) to nonthreatening liquids previously covered or presented as small droplets. We also tested whether the nutritional condition of colonies (i.e., starved or satiated) would affect the intensity and rate of debris dropping. Our results were consistent with the tool‐using behavior hypothesis. Firstly, ants clearly differentiated between honey‐water and water, and they directed more of their foraging effort toward liquids farther from the nest. Secondly, ants performed object dropping even into liquids that did not pose the danger of drowning or becoming entangled. Lastly, the nutritional condition of colonies had a significant effect on the intensity and rate of object dropping, but in the opposite direction than we expected. Our results suggest that the foraging behavior of A. subterranea is more complex than that predicted by the two‐component behavior hypothesis and deserves to be considered as "true" tool use.
Pretreatment Camellia Seeds by Protease and Application to Extraction of Camellia Oil
Authors: Qian Junqing , Zhao Xiaohua , Zhao Changyan , Yang Haiyan , Gou Lihong , Wang Wentao , Guo Hui 
Published: November 2020

AbstractHigh‐temperature pretreatment that is currently used in camellia oil extraction can have negative effects on the quality of camellia oil. In this study, the enzymatic pretreatment of camellia seeds is explored as an alternative to high‐temperature pretreatment. The main conditions for enzymatic pretreatment of camellia seeds including enzyme, pH, temperature, time, and buffer solution are optimized using the response surface methodology. Under the optimal conditions of enzymatic pretreatment, the oil recovery is close to 75%. Moreover, residual oil recovery from camellia seeds subjected to 1398 neutral protease pretreatment (4 g per kg seeds) and high‐temperature pretreatment are 5.62 ± 0.08% and 9.97 ± 0.18%, respectively. The enzymatic pretreatment is further applied to pre‐pressing solvent extraction of camellia oil, the cake oil recovery from camellia seeds subjected to enzymatic pretreatment is higher than that from high‐temperature pretreatment. These results show that enzymatic pretreatment of camellia seeds has potential for application in the oil industry.Practical Applications : This study suggests that enzymatic pretreatment can replace high‐temperature pretreatment and improve oil recovery and oil quality. Ultimately, this method can be used to extract camellia oil.
Identification of the prepared foods promising for dietary folate intake in Beijing, China
Authors: Islam Md Shariful , Mehmood Shahid , Zhang Chunyi , Liang Qiuju 
Published: November 2020

AbstractThe aim of the present study was to analyze folate content and composition in foods consumed daily by Chinese people. The concentration of seven folate derivatives in sixty‐four selected foods was determined by a liquid‐chromatography tandem‐mass spectrometry method. The total folate levels ranged from 0.28 to 129 µg/100 g fresh weight, with an average of 21.18 μg/100 g. The highest folate content was found in boiled egg yolk and waxy corn (>120 µg/100 g), abundant folate levels in cooked vegetables such as hot pepper, spinach, soybean sprout, stem lettuce, coriander, and broccoli (44–72 µg/100 g), and lowest in Coca Cola (0.28 µg/100 g). 5‐Methyl‐tetrahydrofolate was the major folate derivative in various foods, accounting for 72% of the total folates on average, with the highest being 90% in egg yolk. These data will enable estimation of the daily folate intake and allow dietary recommendations to improve folate status in humans.
Associations Between Intake of Sugar‐Containing Beverages in Infancy With Liver Fat Accumulation at School Age
Authors: Geurtsen Madelon L. , Santos Susana , Gaillard Romy , Felix Janine F. , Jaddoe Vincent W. V. 
Published: November 2020

Background and Aims
Sugar‐containing beverage intake is a major risk factor for obesity in both children and adults and appears to be associated with NAFLD in adults. The purpose of this study was to examine the associations between sugar‐containing beverage intake in infancy and liver fat accumulation and NAFLD among school‐aged children.

Approach and Results
In a population‐based prospective cohort study of 1,940 infants, we assessed sugar‐containing beverage intake at 1 year with a validated Food Frequency Questionnaire. Liver fat fraction and NAFLD (liver fat fraction ≥5.0%) were assessed with MR. Higher sugar‐containing beverage intake in infancy was not associated with higher liver fat accumulation at 10 years of age when assessed continuously (SD, 0.03; 95% CI,

0.02, 0.07, per one‐serving/day increase of sugar‐containing beverage intake) or categorically (P = 0.38). However, compared to infants with <1.0 serving/day, those with >2.0 servings/day had the highest odds of NAFLD at 10 years of age (OR, 3.02; 95% CI, 1.34, 6.83). These associations remained borderline significant after additional adjustment for sugar‐containing beverage intake and body mass index at school age (P = 0.13). Stratified analyses showed stronger associations between sugar‐containing beverage intake in infancy and NAFLD at 10 years of age among children of mothers with lower educational attainment (OR, 1.48; 95% CI, 1.12, 1.97) and among children with overweight or obesity (OR, 1.47; 95% CI, 1.05, 2.07).

Conclusions
Higher sugar‐containing beverage intake in infancy was associated with NAFLD in school‐aged children, independent of sugar‐containing beverage intake and body mass index at school age. Limiting the intake of sugar‐containing beverages in infancy may help prevent liver steatosis at school age.
Association of Metabolic Risk Factors With Risks of Cancer and All‐Cause Mortality in Patients With Chronic Hepatitis B
Authors: Lee Yun Bin , Moon Hyemi , Lee Jeong‐Hoon , Cho Eun Ju , Yu Su Jong , Kim Yoon Jun , Zoulim Fabien , Lee Juneyoung , Yoon Jung‐Hwan 
Published: November 2020

Background and Aims
Long‐term antiviral therapy can effectively suppress viral replication and improve clinical outcomes in patients with chronic hepatitis B (CHB), but it cannot eliminate risk of HCC. We investigated the association of metabolic risk factors with the risks of cancer and all‐cause mortality in patients with CHB.

Approach and Results
This nationwide population‐based study from the Korean National Health Insurance Service database consisted of adults with CHB who underwent health examinations from 2007 through 2012. We collected baseline data on metabolic risk factors, including obesity, high blood pressure, hypercholesterolemia, and diabetes. The risks of developing HCC, non‐HCC cancer, and overall death were analyzed according to the metabolic risk profile. The study population composed of 317,856 patients (median age, 46 years [interquartile range, 37‐54 years]; 219,418 men [69.0%]) had 2,609,523.8 person‐years of follow‐up. A total of 18,850 HCCs, 22,164 non‐HCC cancers, and 15,768 deaths were observed during a median follow‐up period of 8.5 years. The metabolic risk factor burden was positively associated with the risks of HCC, non‐HCC cancer, and all‐cause mortality (all P < 0.0001 for trend). Patients with ≥3 metabolic risk factors, compared with those without metabolic risk factors, showed adjusted hazard ratios of 1.23 (95% CI, 1.16‐1.31) for HCC, 1.34 (95% CI, 1.27‐1.41) for non‐HCC cancer, and 1.31 (95% CI, 1.23‐1.39) for all‐cause mortality. Among patients receiving antiviral therapy for over 5 years, the risk‐increasing association of the sum of metabolic risk factors with the risks of HCC and overall death was consistent.

Conclusion
The metabolic risk factor burden was associated with increased risks of HCC, non‐HCC cancer, and all‐cause mortality in patients with CHB.
Public libraries as health literate multi‐purpose workspaces for improving health literacy
Authors: Naccarella Lucio , Horwood Jacqui 
Published: November 2020

AbstractNow more than ever, in this COVID–19 pandemic, our individual and collective ability to access, understand and apply information to inform our health care and broader lifestyle decisions ie, to be health literate ‐ has life or death consequences. This paper reflects upon the proposition of public libraries as health literate multi‐purpose workspaces for improving health literacy. We draw upon our combined experiences as evaluators of organizational health literacy initiatives, and library sector development, engagement and advocacy. Key ideas were presented as part of the 2020 State Library Victoria seminar series on ‘Libraries: The Heart of a Healthy Community’. Key messages included: Public libraries are well positioned to contribute to the health literacy movement, as they provide the general public with: universal free access to information and services; extensive in‐house and outreach educational collaborative learning opportunities; and health and wellbeing support by being welcoming, safe, and trusted community spaces. To date, limited discussion exists about conceptualizing public libraries as health literate multi‐purpose workspaces for supporting and sustaining public library health literacy efforts. A health literate organizational framework is suggested to support libraries simply supporting health information literacy to being recognised as health literate organizations. Five workspace principles (empowerment, equitable, inclusive, collaborative and integrated) are suggested to provide directions for public libraries as health literate multi‐purpose workspaces for improving the health literacy of individuals, communities, organizations and indeed systems. To inform the design, implementation and evaluation of public libraries as workspaces for improving health literacy, key principles‐focused evaluation questions are suggested for consideration.So what?Public Libraries as welcoming, safe, and trusted community organizations are well placed to be health literate multipurpose workspaces for improving health literacy.
Tensions in talent: A micro practice perspective on the implementation of high potential talent development programs in multinational corporations
Authors: Garavan Thomas N. , Morley Michael J. , Cross Christine , Carbery Ronan , Darcy Colette 
Published: November 2020

AbstractDrawing on the utility of paradox theory and adopting a micro‐practice perspective, we explore the implementation of high potential talent development (HiPo) programs in multinational corporations (MNCs). In doing so we take an emergent approach to implementation and seek to cast light on some of the day‐to‐day tensions that arise, along with key responses that salient actors appear to make when navigating these paradoxes. Through an inductive, mixed method study involving nine MNCs, we found that, over time, actors construed three particular sets of performance paradoxes relating to variations in their goals, in their beliefs, and in their roles in the particular HiPo programs in focus. We also found that these actors responded to the tensions experienced using an assortment of both defensive and proactive actions. Finally, we uncovered that both the tensions and responses in play vary with the implementation phase of the HiPo program. We highlight some key practice implications that arise from our work, acknowledge attendant limitations and identify possible directions for future research.
The accuracy of drainage network delineation as a function of environmental factors: A case study in Central and Northern Sweden
Authors: Yan Yanzi , Lidberg William , Tenenbaum David E. , Pilesjö Petter 
Published: November 2020

AbstractDrainage networks delineated from Digital Elevation Models (DEMs), are the basis for the modelling of geomorphological and hydrological processes, biogeochemical cycling, and water resources management. Besides providing effective models of water flows, automatically extracted drainage networks based on topography can diverge from reality to varying degrees. The variability of such disagreement within catchments has rarely been examined as a function of the heterogeneity of land cover, soil type, and slope in the catchment of interest. This research gap might not only substantially limit our knowledge of the uncertainty of hydrological prediction, but can also cause problems for users attempting to use the data at a local scale. Using 1:100000 scale land cover maps, Quaternary deposits maps, and 2 m resolution DEMs, it is found that the accuracy of delineated drainage networks tends to be lower in areas with denser vegetation, lower hydraulic conductivity, and higher erodibility. The findings of this study could serve as a guide for the more thoughtful usage of delineated drainage networks in environmental planning, and in the uncertainty analysis of hydrological and biochemical predictions. Therefore, this study makes a first attempt at filling the knowledge gap described above.
Time‐varying responses of stock returns to market illiquidity: Stress scenario with regime‐switching framework
Authors: Ben Soltane Héla , Naoui Kamel 
Published: November 2020

AbstractWe test the time‐varying stock return responses to both expected and unexpected market illiquidity. Using a Markov‐switching methodology on Tunisian market data, we find that expected and unexpected market illiquidity effects on Tunisian small‐cap returns are always negative and stable. But for large caps, unexpected market illiquidity (illiquidity shock) effect on stock returns varies over time across two distinct regimes. In the first regime, illiquidity shocks have small effect on stock returns, whereas in the second regime, this effect rises threefold compared to its magnitude in first regime. The second regime (stress scenario) is short lived and characterized by high volatility. We also find that effect of expected market illiquidity on large cap returns is insignificant. In addition, we investigate the factors that lead to the stress scenario on stock exchange of Tunis. We find that stress scenario is contingent to funding illiquidity and economic distress in Tunisia. Results prove that Tunisian economic distress occurred in the context of subprime crisis and Tunisian political crisis of 2010.
Clinical features of pregnant women in Iran who died due to COVID‐19
Authors: Amini Moghadam Soheila , Dini Parisa , Nassiri Setare , Motavaselian Mahtab , Hajibaba Marzieh , Sohrabi Masoudreza 
Published: November 2020

AbstractBackgroundTo evaluate the clinical presentation of pregnant women in Iran who died due to COVID‐19.MethodsData were evaluated of pregnant women who died following a laboratory diagnosis of COVID‐19. The data were obtained from electronic medical records. Additionally, a questionnaire was completed for each patient, including demographic, clinical, laboratorial, imaging, and treatment data. In case of missing information, a member of the research team contacted the first‐degree relatives via phone.ResultsOf 32 pregnant women who tested positive for COVID‐19, 15 were enrolled into the study (mean age 30.0 ± 5.0 years). The mean time from first symptoms to death was 12 ± 7.0 days. Pre‐existing comorbidities were seen in six patients. The main presentations at admission were fatigue and coughing, but most of the women had a fever below 38 °C. Increased white blood cell count and neutrophils were noticeable. A significant drop of saturation of O2 with ground glass and consolidation seen in both lungs were prominent. The most common complications were acute respiratory distress syndrome followed by respiratory failure.ConclusionComputed tomography findings, O2 pressure, and regular blood assessment may be considered suitable indicators for the surveillance of patients.
Parabens enhance the calcium‐dependent testicular mitochondrial permeability transition: Their relevance on the reproductive capacity in male animals
Authors: Martins Fátima C. , Videira Romeu A. , Oliveira Maria Manuel , Silva‐Maia Daniela , Ferreira Fernanda M. , Peixoto Francisco P. 
Published: November 2020

AbstractParabens, alkyl ester derivatives from p‐hydroxybenzoic acid, are extensively used as antimicrobial preservatives. Nonetheless, due to its widespread and massive employment, several studies highlighted the association between parabens and alterations in the reproductive system. This study aimed to relate the adverse effect of the most commonly used parabens in testis mitochondria with male fertility. From all the parabens used, propyl and butyl were the ones that most negatively decreased the respiratory control ratio. In the case of butyl, inhibitions of 20% and 60% were observed, respectively, at the lowest and highest concentration, when compared to the control group. The membrane potential was only significantly affected by propyl (14%) and butyl (31%), and at a concentration of 250 µM. Succinate dehydrogenase, cytochrome c oxidase, and ATPase activities showed a nonsignificant decrease. Cytochrome c reductase, on the other hand, showed statistically significant inhibitions for both propyl (56%) and butylparaben (55%). The susceptibility to the mitochondrial permeability transition pore (MPTP) opening was increased by all parabens, although this increase was markedly significant for propyl and butyl. These results show that the susceptibility of mitochondria to parabens is dependent on the alkyl chain length and parabens hydrophobicity, and the main mitochondrial target is Complex II–III and MPTP. Hence, this study demonstrates the contribution of parabens exposition to the inhibition of testis mitochondrial function and their putative noxious effect on the male reproductive system.
The novel ALK inhibitor ZX‐29 induces apoptosis through inhibiting ALK and inducing ROS‐mediated endoplasmic reticulum stress in Karpas299 cells
Authors: Zhou Xuejiao , Zhang Xiaoning , Wu Zhuzhu , Xu Xiaobo , Guo Ming , Zhai Xin , Zuo Daiying , Wu Yingliang 
Published: November 2020

AbstractIt is a well‐known fact that 60%−85% of anaplastic large cell lymphoma (ALCL) is mainly driven by the anaplastic lymphoma kinase (ALK) fusion protein. Although ALK‐positive ALCL patients respond significantly to ALK inhibitors, the development of resistance is inevitable, which requires the development of new therapeutic strategies for ALK‐positive ALCL. Here, we investigated the anticancer activities of N‐(2((5‐chloro‐2‐((2‐methoxy‐6‐(4‐methylpiperazin‐1‐yl)pyridin‐3yl)amino)pyrimidin‐4‐yl)amino)phenyl)methanesulfonamide (ZX‐29), a newly synthesized ALK inhibitor, against nucleophosmin−ALK‐positive cell line Karpas299. We demonstrated that ZX‐29 decreased Karpas299 cells growth and had better cytotoxicity than ceritinib, which was mediated through downregulating the expression of ALK and related proteins, inducing cell cycle arrest, and promoting cell apoptosis. Moreover, ZX‐29‐induced cell apoptosis by inducing endoplasmic reticulum stress (ERS). In addition, ZX‐29 increased the generation of reactive oxygen species (ROS), and cells pretreatment with N‐acetyl‐
l‐cysteine could attenuate ZX‐29‐induced cell apoptosis and ERS. Taken together, ZX‐29 inhibited Karpas299 cell proliferation and induced apoptosis through inhibiting ALK and its downstream protein expression and inducing ROS‐mediated ERS. Therefore, our results provide evidence for a novel antitumor candidate for the further investigation.