bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coordination design of the coal-electricity supply chain contract for difference based on prospect theory
Authors: Li Weiwei , Zhao Jin-Lou , Dong Linxiao , Wu Chong 
Published: March 2020

Purpose
Long-term contract is an important developing direction of China's coal industry coordination. This paper aims to discuss how to use contract for difference (CFD) to avoid risk and effectively increase the benefit of both coal and thermal power plants in the coal-electricity supply chain.

Design/methodology/approach
Based on prospect theory, this paper takes the risks and benefits of the coal and coal-fired power plants in the coal supply chain under CFD into balanced consideration to construct the contract coordination mechanism. In this mechanism, the coal demand in the coal supply chain equilibrium under centralized decision-making is regarded as the total annual volume of transactions needed to design the contract coordination mechanism and solve double marginalization. Then, based on prospect theory, in the construction of CFD, this paper takes the income of power and coal enterprises when they are in equilibrium under Stackelberg non-cooperative game as the reference point. In addition, considering that coal demand is a random variable, the CFD with a one-year trading session can be designed.

Findings
The research derives the coal price of the contract for difference, contract trading volume and its proportion of the total trading volume. A numerical example shows that the model above can be used to effectively avoid the risk of both coal and electricity sides.

Originality/value
To solve the conflict between coal enterprises and thermal power plants, let the coal-electricity supply chain be converted from non-cooperative game to cooperative game. Based on the prospect theory, this paper takes the income of the non-cooperative game of coal and thermal power plants as a reference point and considers how to design the coordination mechanism, the contract for difference, so as to make the two parties cooperate to solve the double marginal utility of the non-cooperative game in a chain supply. The main innovation of the work lies in the following: first, the coal demand when the coal-electrical supply chain is in balance under centralized decision-making is taken as the total annual trading volume needed to design the contract coordination mechanism and solve double marginalization. Second, based on prospect theory, in the construction of CFD, the benefits of coal-fired power plants and coal enterprises when both sides are in equilibrium under the Stackelberg non-cooperative game are taken as the reference points, and coal demand is taken as a random variable to design the CFD with a one-year transaction period. The price of coal that is not traded through CFD is calculated according to the daily market price. Third, this paper proposes the prospect M-V criterion of the risk-benefit equilibrium of both power and coal enterprises, which means that the risk-benefit equilibrium of both sides is the prospect variance effect of both sides relative to the reference point benefit divided by the prospect expectation effect.
Trust in leader as a pathway between ethical leadership and safety compliance
Authors: Enwereuzor Ibeawuchi K. , Adeyemi Busayo A. , Onyishi Ike E. 
Published: March 2020

Purpose
Although a great number of studies have established the important role of leadership in workplace safety, it appears researchers are yet to consider the role that trust in leaders could play between ethical leadership and safety compliance within healthcare. To address that imbalance, this study aims to investigate the relationship between ethical leadership and safety compliance, with trust in the leader as the mediator.

Design/methodology/approach
Data were collected in three time periods from 237 hospital staff nurses (76.8 per cent women and 23.2 per cent men). Ordinary least squares regression-based path analysis using PROCESS for statistical package for the social sciences (SPSS) macro was used to test the hypotheses.

Findings
Results showed that ethical leadership was positively related to trust in a leader but was not related to safety compliance. In addition, trust in leader was positively related to safety compliance and also mediated the positive relationship between ethical leadership and safety compliance.

Research limitations/implications
The data were collected within healthcare organisations in a few localities in Nigeria, making it difficult to generalise the findings beyond the current sample let alone the entire country or even continent.

Practical implications
The findings imply that ethical leadership may not be directly effective in improving the safety compliance of subordinate nurses unless such a leader first develops a trust-based relationship with the subordinates.

Originality/value
The current study builds on and extends the burgeoning research in the area of leadership and employee outcome by investigating not only the direct relationship between ethical leadership and safety compliance but also incorporating trust in a leader as a mediator of this relationship.
Abnormal keratinization and cutaneous inflammation in Mal de Meleda
Authors: Kudo Mari , Ishiura Nobuko , Tamura‐Nakano Miwa , Shimizu Teruo , Kamata Masahiro , Akasaka Eijiro , Nakano Hajime , Okuma Yoshiaki , Tada Yayoi , Okochi Hitoshi , Tamaki Takeshi 
Published: March 2020

AbstractMal de Meleda (MDM) is a rare, autosomal recessive form of palmoplantar keratoderma due to mutations in the gene, encoding for secreted lymphocyte antigen 6/urokinase‐type plasminogen activator receptor related protein 1 (SLURP1). We report a four‐year‐old Taiwanese MDM female case whose biopsy specimen of hyperkeratotic lesions showed abnormal keratinization and cutaneous inflammation with characteristic transmission electron microscopic (TEM) findings and immunostaining results. The patient presented with pruritic and severely hyperkeratotic plaques on the bilateral palms and soles whichwere fringed with erythematous scaly areas. A homozygous c.256 G>A mutation, predicting a conversion of p.Gly86Arg, in SLURP1gene was detected. Histopathological examinations showed marked hyperkeratosis, acanthosis and hypergranulosis in the epidermis, accompanied by perivascular lymphocytic infiltrates in the dermis. The whole layers of the epidermis and perivascular infiltrates of the dermis were stained positive with anti‐tumor necrosis factor alpha (TNFα) antibody in the biopsy specimen from the sole and the ankle. TEM examination of the biopsy specimen from the plantar hyperkeratotic plaque showed various‐sized vacuoles surrounding nuclei of many keratinocytes in the spinous layer. In addition, there were numerous irregular keratohyaline granules in the granular layer. Several microorganisms and many lipid‐like droplets were found in the thickened cornified layer. SLURP1 protein is known as a marker of late differentiation, predominantly expressed in the granular layer, and also known to have an inhibitory effect on TNFα release. Our results exhibited excessive TNFα expression in keratinocytes and perivascular infiltrates of the dermis, and several characteristic morphological observations of keratinocytes in MDM.
Comparative analysis of larval growth in Lepidoptera reveals instar‐level constraints
Authors: Kivelä Sami M. , Davis Robert B. , Esperk Toomas , Gotthard Karl , Mutanen Marko , Valdma Daniel , Tammaru Toomas 
Published: March 2020

AbstractJuvenile growth trajectories evolve via the interplay of selective pressures on age and size at maturity, and developmental constraints. In insects, the moulting cycle is a major constraint on larval growth trajectories.Surface area to volume ratio of a larva decreases during growth, so renewal of certain surfaces by moulting is likely needed for the maintenance of physiological efficiency. A null hypothesis of isometry, implied by Dyar's Rule, would mean that the relative measures of growth remain constant across moults and instars.We studied ontogenetic changes and allometry in instar‐specific characteristics of larval growth in 30 lepidopteran species in a phylogenetic comparative framework.Relative instar‐specific mass increments (RMI) typically, but not invariably, decreased across instars. Ontogenetic change in RMIs varied among families with little within‐family variation. End‐of‐instar growth deceleration (GD) became stronger with increasing body size across instars. Across‐instar change in GD was conserved across taxa. Ontogenetic allometry was generally non‐isometric in both RMI and GD.Results indicate that detailed studies on multiple species are needed for generalizations concerning growth trajectory evolution. Developmental and physiological mechanisms affecting growth trajectory evolution show different degrees of evolutionary conservatism, which must be incorporated into models of age and size at maturation.
NO and N2O transformations of diverse fungi in hypoxia: evidence for anaerobic respiration only in Fusarium strains
Authors: Keuschnig Christoph , Gorfer Markus , Li Guofen , Mania Daniel , Frostegård Åsa , Bakken Lars , Larose Catherine 
Published: March 2020

SummaryFungal denitrification is claimed to produce non‐negligible amounts of N2O in soils, but few tested species have shown significant activity. We hypothesized that denitrifying fungi would be found among those with assimilatory nitrate reductase, and tested 20 such batch cultures for their respiratory metabolism, including two positive controls, Fusarium oxysporum and Fusarium lichenicola, throughout the transition from oxic to anoxic conditions in media supplemented with . Enzymatic reduction of (NIR) and NO (NOR) was assessed by correcting measured NO‐ and N2O‐kinetics for abiotic NO‐ and N2O‐production (sterile controls). Significant anaerobic respiration was only confirmed for the positive controls and for two of three Fusarium solani cultures. The NO kinetics in six cultures showed NIR but not NOR activity, observed through the accumulation of NO. Others had NOR but not NIR activity, thus reducing abiotically produced NO to N2O. The presence of candidate genes (nirK and p450nor) was confirmed in the positive controls, but not in some of the NO or N2O accumulating cultures. Based on our results, we conclude that only the Fusarium cultures were able to sustain anaerobic respiration and produced low amounts of N2O as a response to an abiotic NO production from the medium.
Silicosis in artificial stone workers: Spectrum of radiological high‐resolution CT chest findings
Authors: Jones Catherine M , Pasricha Sundeep S , Heinze Stefan B , MacDonald Sharyn 
Published: March 2020

SummarySilicosis in artificial stone workers has become increasingly recognised in Australia over the last two years, with a large proportion of screened workers showing imaging features of the disease. The spectrum of findings has differed from the classical silicosis previously described, with many features of accelerated disease, including ground‐glass opacities and progressive massive fibrosis. This cohort of patients presents after exposure to a unique product high in silica and other binding agents, and the patterns of disease on imaging in this cohort are not previously described. This article reviews the radiological features seen in different forms of silicosis seen to date in this Australian cohort.
Chemoradiotherapy followed by durvalumab in patients with unresectable advanced non‐small cell lung cancer: Management of adverse events
Authors: Miura Yu , Mouri Atsuto , Kaira Kyoichi , Yamaguchi Ou , Shiono Ayako , Hashimoto Kosuke , Nishihara Fuyumi , Shinomiya Shun , Akagami Tomoe , Murayama Yoshitake , Abe Takanori , Noda Shin‐ei , Kato Shingo , Kobayashi Kunihiko , Kagamu Hiroshi 
Published: March 2020

BackgroundChemoradiotherapy followed by durvalumab is the standard treatment for the patients with local advanced non‐small cell lung cancer (NSCLC). There is a real‐world data about the management of adverse events, such as pneumonitis, according to the different institutions. Here, we present the experience regarding the management of adverse events after the initiation of durvalumab as daily practice.MethodsFrom July 2018 to August 2019, 41 patients with locally advanced NSCLC, who underwent chemoradiotherapy followed by durvalumab, were retrospectively analyzed in the study using our medical records.ResultsThe median age of patients was 72 years (range: 51–80 years). A total of 33 patients were male and eight were female, and 40 patients (98%) received a total radiation dose of 60 Gy as concomitant chemoradiotherapy. The median V20 for the entire cohort was 18.9% (range: 3.5–29.9). Any adverse events during chemoradiotherapy and durvalumab were observed in 32 patients (78.0%), while three patients (7.3%) experienced grade 3 toxicities. In total, 25 (61.0%) patients experienced pneumonitis, four (9.8%) thyroid dysfunction, three (7.3%) myopathy, two (4.9%) rash or eruption, one (2.4%) bowel disease and one (2.4%) malaise. Grade 3 pneumonitis, thyroid dysfunction and myopathy were observed in one (2.4%), one (2.4%) and one (2.4%), respectively. A total of 22 (53.7%) patients were unable to continue durvalumab due to pneumonitis. However, durvalumab was finally readministered to six patients.ConclusionsThe adherence to lung dose constraints such as V20 as well as close treatment monitoring are a prerequisite for the management of pneumonitis during maintenance therapy with durvalumab.
Spontaneous versus controlled mechanical ventilation in patients with acute respiratory distress syndrome – Protocol for a scoping review
Authors: Aslam Tayyba N. , Klitgaard Thomas L. , Møller Morten H. , Perner Anders , Hofsø Kristin , Skrubbeltrang Conni , Flaatten Hilde I. , Rasmussen Bodil S. , Laake Jon H. 
Published: March 2020

BackgroundIn caring for mechanically ventilated adults with acute respiratory distress syndrome (ARDS), clinicians are faced with an uncertain choice between controlled or spontaneous breathing modes. Observational data indicate considerable practice variation which may be driven by differences in sedation and mobilisation practices. The benefits and harms of either strategy are largely unknown.MethodsA scoping review will be prepared according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) extension for scoping reviews. We will review the clinical literature on controlled vs spontaneous breathing in mechanically ventilated patients with ARDS of any severity. Studies reporting on qualitative and/or quantitative data from any world region will be considered. For inclusion, studies must include data on mechanically ventilated patients with ARDS who are allowed spontaneous (triggered ventilation). Searches will be conducted in four electronic databases without any limitation on publication date and language. We will assess the quality of evidence according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology, where appropriate.ConclusionWe will perform a scoping review of the clinical literature on controlled vs spontaneously breathing in mechanically ventilated patients who fulfil ARDS criteria (including acute lung injury). This is to elucidate if a pragmatic clinical trial comparing controlled and spontaneous mechanical ventilation is warranted and will allow us to formulate relevant research questions.
Impaired integrin α5/β1‐mediated hepatocyte growth factor release by stellate cells of the aged liver
Authors: Rohn Friederike , Kordes Claus , Buschmann Tobias , Reichert Doreen , Wammers Marianne , Poschmann Gereon , Stühler Kai , Benk Amelie S. , Geiger Fania , Spatz Joachim P. , Häussinger Dieter 
Published: March 2020

AbstractHepatic blood flow and sinusoidal endothelial fenestration decrease during aging. Consequently, fluid mechanical forces are reduced in the space of Disse where hepatic stellate cells (HSC) have their niche. We provide evidence that integrin α5/β1 is an important mechanosensor in HSC involved in shear stress‐induced release of hepatocyte growth factor (HGF), an essential inductor of liver regeneration which is impaired during aging. The expression of the integrin subunits α5 and β1 decreases in liver and HSC from aged rats. CRISPR/Cas9‐mediated integrin α5 and β1 knockouts in isolated HSC lead to lowered HGF release and impaired cellular adhesion. Fluid mechanical forces increase integrin α5 and laminin gene expression whereas integrin β1 remains unaffected. In the aged liver, laminin β2 and γ1 protein chains as components of laminin‐521 are lowered. The integrin α5 knockout in HSC reduces laminin expression via mechanosensory mechanisms. Culture of HSC on nanostructured surfaces functionalized with laminin‐521 enhances Hgf expression in HSC, demonstrating that these ECM proteins are critically involved in HSC function. During aging, HSC acquire a senescence‐associated secretory phenotype and lower their growth factor expression essential for tissue repair. Our findings suggest that impaired mechanosensing via integrin α5/β1 in HSC contributes to age‐related reduction of ECM and HGF release that could affect liver regeneration.
Sexual dimorphism in limb long bones of the German Shepherd Dog
Authors: Belhaoues Fabien , Breit Sabine , Forstenpointner Gerhard , Gardeisen Armelle 
Published: March 2020

AbstractThe study of sexual dimorphism in dog anatomy, especially with regard to skeletal elements, has received little attention. The present work focuses on elements of the canine stylo‐ and zeugopodium, less documented than the skull or pelvis in the literature. In order to identify only sex‐dependent effects, we analysed a single breed: the German Shepherd Dog. Data come from 25 dogs, with a balanced sex ratio (12 males and 13 females). Four skeletal elements of the forelimb and hindlimb (humerus, radius, femur, tibia) were each measured using seven linear morphometric variables. Univariate and multivariate analyses were then performed on these 28 variables. For all measurements, males are on average larger than females, with a mean sexual dimorphism ratio of 1.07. Sexual dimorphism is significant for 92.8% of the variables. Except of femoral measurements, diaphyseal values show the highest grade of sexual dimorphism. The mean level of disparity is higher in the forelimb (1.08) than in the hindlimb (1.05). A significant dimorphism is shown for the first component of principal component analyses conducted on each skeletal element, and for the second component with humerus measurements. Discriminant functions for sex identification give success rates included between 82% for the radius and 93% for the femur, the latter providing the highest reported score for sex identification in dogs from any skeletal element. These complementary statistic methods highlight a more dimorphic forelimb in size and a more dimorphic hindlimb in shape.
The Effects of Cannabis Use: A Test Among Dual Electronic and Combustible Cigarette Users
Authors: Mayorga Nubia A. , Garey Lorra , Nizio Pamella , Buckner Julia D. , Zvolensky Michael J. 
Published: March 2020

Background and ObjectivesDespite greater rates of cannabis use among those that smoke combustible cigarettes, it is currently unknown whether cannabis use is related to e‐cigarette dependence or maladaptive beliefs about combustible cigarettes. Therefore, the current study sought to identify whether adult dual users of combustible and e‐cigarettes (ie, dual users) who also used cannabis differed from dual users who did not use cannabis on e‐cigarette dependence severity, perceived barriers to quitting, and perception of risks and of benefits of e‐cigarettes.MethodsParticipants were 414 current dual users (48.3% female, Mage = 35.1 years, SD = 10.0), 51% of whom were current cannabis users.ResultsDual users who reported current cannabis use evidenced more severe dependence on e‐cigarettes (ηp2 = 0.12), higher perceived barriers for quitting e‐cigarettes (ηp2 = 0.06), and greater perceived benefits (ηp2 = 0.03) as well as higher perception of risks (ηp2 = 0.03) for using e‐cigarettes. The results were evident after controlling for the variance associated with sex, age, education, income, and frequency of e‐cigarette use.Discussion and ConclusionsOverall, the current findings suggest cannabis may be an important type of substance use behavior that is relevant to e‐cigarette dependence and beliefs about use and quitting among adult dual users.Scientific SignificanceThe present data extend current understanding of dual users by contextualizing cannabis use within e‐cigarette and combustible cigarette use behaviors and highlight a potential substance use behavior that may be targetable in the framework of nicotine cessation. (Am J Addict 2020;00:00–00)
The effectiveness of interventions to improve self‐management for adolescents and young adults with allergic conditions: A systematic review
Authors: Knibb Rebecca C. , Alviani Cherry , Garriga‐Baraut Teresa , Mortz Charlotte G. , Vazquez‐Ortiz Marta , Angier Elizabeth , Blumchen Katerina , Comberiati Pasquale , Duca Bettina , DunnGalvin Audrey , Gore Claudia , Hox Valerie , Jensen Britt , Pite Helena , Santos Alexandra F. , Sanchez‐Garcia Silvia , Gowland M. Hazel , Timmermans Frans , Roberts Graham 
Published: March 2020

AbstractBackgroundThis systematic review aimed to review the literature on interventions for improving self‐management and well‐being in adolescents and young adults (11‐25 years) with asthma and allergic conditions.MethodsA systematic literature search was undertaken across eight databases. References were checked by two reviewers for inclusion. Study data were extracted, and their quality was assessed in duplicate. A narrative synthesis was undertaken.ResultsA total of 30 papers reporting data from 27 studies were included. Interventions types were psychological (k = 9); e‐health (k = 8); educational (k = 4); peer‐led (k = 5); breathing re‐training (k = 1). All interventions were for asthma. Psychological interventions resulted in significant improvements in the intervention group compared with the control group for self‐esteem, quality of life, self‐efficacy, coping strategies, mood and asthma symptoms. E‐Health interventions reported significant improvements for inhaler technique, adherence and quality of life. General educational interventions demonstrated significantly improved quality of life, management of asthma symptoms, controller medication use, increased use of a written management plan and reduction in symptoms. The peer‐led interventions included the Triple A (Adolescent Asthma Action) programme and a peer‐led camp based on the Power Breathing Programme. Improvements were found for self‐efficacy, school absenteeism and quality of life.ConclusionAlthough significant improvements were seen for all intervention types, many were small feasibility or pilot studies, few studies reported effect sizes and no studies for allergic conditions other than asthma met the inclusion criteria. Research using large longitudinal interventional designs across the range of allergic conditions is required to strengthen the evidence base.