bluuebunny/crossref_metadata_2025_split huggingface dataset:
Virtual Screening of Natural Compounds to Identify Potential Inhibitors of COVID-19 Protease using Molecular Docking
Authors: Patel Jimish R , Prajapati Laxman M. , Joshi Hirak V , Shah Ujash A 
Published: September 2020

COVID-19 disease has spread quickly across the globe after its first detection in late December 2019 in Wuhan, China. The disease is considered as a potential global health threat by world health organization due to its high emerging deaths. Coronaviruses are transmitted by respiratory aerosols producing mild upper respiratory infections. Currently, no vaccine or specific COVID-19 inhibitors are available for treatment except repurposed drugs. The COVID-19 virus genome has ~30,000 nucleotides. Its replicase gene encodes overlapping polyproteins necessary for viral replication and transcription. Recently COVID-19 main protease was successfully crystallized and made available in Protein Data Bank for public use. Several studies report medicinal plants to have antiviral bioactivities. Application of in silico computer‐based docking studies involving small molecules could be time saving for irrelevant in vivo models. In the present study, we have investigated 500 natural compounds from different plants having antiviral properties. We have also screened several protease inhibitors and other repurposed drugs claimed to be active against COVID-19. The docking was performed on Autodock vina, using grid size 22, 22, 24 along the X, Y, and Z axes with 1.000 A˚ spacing. The docked positions in binding pockets were visualized using Discovery studio 3.5 software. Most of the repurposed protease inhibitors were having good binding energy, saquinavir being the most potent. Among natural compounds, jervine and isoacteoside were found to be having good binding with protease protein. It was observed that flavonoid was the commonest chemical group amongst most potent natural compounds. The amino acids Thr26, Asn142, Gly143, Ser144, Cys145, His163, and Glu166 showed strong H-bond interactions with docked compounds. The conclusion of the recent study will help researchers to identify the better drug to battle COVID-19. To be brief, our findings emphasize a promising pharmaceutical perspective for targeting main protease of novel coronavirus. However further preclinical and clinical trials should be carried out to validate these potential compounds.
Comparison of Anti-inflammatory, Analgesic, Antipyretic Properties of Selected Red algae - Hypnea musciformis (Wulfen) J V Lamouroux., Gracilaria dura (C Agardh) J Agardh. and Kappaphycus alvarezii (Doty) Doty ex Silva
Authors: K Murugan , S s Sumayya , A S Lubaina 
Published: September 2020

Marine natural products from seaweeds have been the focus of research for novel products of pharmacological interest. Bioactivities of the phytochemicals derived from marine algae are important ingredients in many products, such as cosmetics and drugs for treating cancer and other lifestyle disorders. In this context, the aim of the present study is to compare the anti-inflammatory, analgesic, antipyretic properties of the purified terpenoids from the selected red algae Hypnea musciformis, Gracilaria dura and Kappaphycus alvarezii. Initially, the acute toxicity of the purified terpenoid extract was analyzed and was greater than 4000 mg/kg bw. In vitro BSA denaturation assay revealed significant % inhibition as compared to control. In the carrageenan induced paw edema, the purified terpenoids extract of H. musciformis exhibited remarkable soothing activity with 68.8% percentage of inhibition, which was comparable with that of indomethacin. Meanwhile G. dura and K. alvarezii showed 53 and 50% of inhibition respectively. Analgesic activity was determined by hot plate and acetic acid induced writhing test. In the hot plate test, terpenoids extract of H. musciformis and G. dura significantly increased the hot-plate latency as compared to normal saline, which reflects their analgesic efficacy. In the writhing test, terpenoid extracts from H. musciformis, G. dura and K. alvarezii inhibited the writhing response induced by acetic acid in a concentration dependent manner that suggests its varied mode of inhibition of stretching episodes. Lastly, the antipyretic activity was analyzed. Terpenoid extracts from H. musciformis, G. dura and K. alvarezii revealed a significant (P < 0.01) antipyretic activity up to 180 min. In summary, the study demonstrates the anti-inflammatory, analgesic and antipyretic effects of terpenoids extracts from H. musciformis, G. dura and K. alvarezii on experimental models, suggesting its therapeutic potential in the treatment of peripheral painful and inflammatory pathologies.
Pemakaian Natrium Karbonat Pada Pencapan Alkali-Discharge dengan Zat Warna Dispersi pada Kain Poliester
Authors: Luciana Luciana 
Published: September 2020

Abstract – Polyester fabrics are the most popular clothing material in the textile product manufacturing process and are widely used. Small floral motifs, line or small dots that are sharp and bright (more than one color) on the basis of contrasting or dark colors usually obtained by discharge printing or resist printing, because it is not easy to do by direct printing in a large amount of production. In printing alkali discharge, polyester fabrics are used dispersion dyes that can be damaged by alkali (azo type) as the base color. Color motifs are used dispersion dyes that are resistant to alkalis (anthraquinone type) which do not have ester groups in their chromophore. The purpose of this study was to determine the extent to the influence of the concentration of using sodium carbonate 100, 150, 200, 250 g/kg paste as etching agent and fixation time 4,6,8 minutes temperature 180 °C, then testing the degree of fabric white, color difference, fabric tensile strength and color fastness against washing and rubbing. The optimum conditions were achieved in sodium carbonate 200 g/kg paste, temperature 180 °C for 6 minutes, white degree of fabric Δ K/S 0.01684, color difference value Δ E= 2,81, fabric tensile strength of 17,40 kg towards warp 18,05 kg towards the feed, fastness to washing 4-5, color fastness to wet rubbing and dry rubbing 4-5.
Keywords : sodium carbonate, discharge printing, azo, anthraquinone, polyester
On a composition of combustion products at a burning of methane-fluorinated hydrocarbon mixtures in air
Authors: Шебеко Алексей Юрьевич , Шебеко Юрий Николаевич 
Published: September 2020

Выполнена расчетная оценка равновесного состава продуктов горения околостехиометрических смесей вида метан - фторированный углеводород - воздух с использованием как программного комплекса Chemical Workbench, так и предложенной в настоящей работе упрощенной методики. Найдено, что основными продуктами горения являются CO, HO, CO, HF. При этом концентрации прочих продуктов горения имеют существенно более низкие значения. С помощью программного комплекса FDS выполнен расчет динамики концентраций опасных продуктов (СО, HF) в атмосфере модельного помещения объемом 12,6 м. Найдено, что для указанного помещения предельно допустимая концентрация CO достигается через 730 с после начала горения, а HF - практически мгновенно. Результаты работы могут быть полезны при применении фторированных углеводородов для пожаротушения и флегматизации горючих газовых смесей.
Calculations of equilibrium compositions of combustion products at burning of near stoichiometric mixtures of methane-fluorinated hydrocarbon-air are presented. The program tool Chemical Workbench was used. Also a Simplified method was proposed. It was found that CO, HO, CO and HF are the main combustion products, and the concentration of other products are much more lower. The results of the calculations of the concentrations of the above mentioned products (CO, HO, CO and HF) by means of the simplified method are close to that obtained by the tool Chemical Workbench ones. The concentrations of CO and HF (the main hazardous products) as a function of time were determined for a typical room volume of 12, 6 m using the program tool FDS 6. It was found that a limiting allowable concentration of CO was reached after 730 s from the burning beginning, but at the case of HF this concentration was reached almost instantaneously. The results of this study can be used at an application of the fluorinated hydrocarbons for fire extinguishing and inertization of flammable gaseous mixtures.
Investigation in the kinetics of thermal and thermo-oxidative degradation of wood treated with fire-retardants and untreated wood
Authors: Копылов Николай Петрович , Кузнецов Александр Евгеньевич , Сушкина Елена Юрьевна , Яшин Владимир Васильевич 
Published: September 2020

Разработана экспериментальная методика определения механизма огнезащитного действия антипиренов на основе изучения кинетики термической и термоокислительной деструкции древесины. Отработка методики проведена на антипирене MgCl (бишофит). Методика основывается на количественной оценке при термическом разложении древесины выхода продуктов деструкции: CO, CO, дымового аэрозоля. В качестве приборной базы используются хроматографы, фотометр фотоэлектрический для аэрозолей, спектрофотометр.
Water with various additives is used during extinguishing forest fires. Fire-retardants are used as additives in most cases. The selection of fire-retardants depends on the level of increase in extinguishing effectiveness at their addition to water. The purpose of this work is to develop an experimental method for evaluating the fireproof effect of flame retardants solutions. This method is based on the investigation of the kinetics of thermal and thermo-oxidative degradation of treated wood with flame retardants and untreated wood. In practice, bischofite and diammonium phosphate are often used as additives. Investigations were conducted using MgCl (bischofite). The explanation of the fireproof effect of the bischofite solution is based on the study of the yield of decomposition products (CO, CO, smoke aerosol) of wood treated with fire-retardant and untreated wood. The instrument base includes chromatographs «Gasochrom 3101», «Tsvet 152», photoelectric photometer for aerosols, spectrophotometer IKS-29. Wood samples were subjected to thermal and thermo-oxidative degradation in nitrogen flow or air flow with a volume velocity of 60 ml · min. Pulse heating in the pyrolysis furnace was carried out in the temperature range from 350 to 550 °C. The significant increase in fire resistance of wood treated with fire-retardant was found as a result of researches using the proposed method. It was shown that the theory of the coating layer, thermal and gas theory of catalytic dehydration are not suitable for explaining the mechanism of fireproof action of an aqueous solution of magnesium halides. Although it is not excluded the inhibition of gas-phase oxidation of cellulose degradation products by hydrogen halides released when heating aqueous solutions of magnesium halides.
Activity analysis of the judicial-expert establishments of the Federal Fire Service Fire-Testing Laboratory for 2019
Authors: Зубань Ольга Петровна , Люлин Вячеслав Алексеевич , Михалев Виталий Александрович , Аносова Надежда Викторовна , Вишнякова Екатерина Алексеевна , Двинянина Светлана Викторовна 
Published: September 2020

В статье приведены основные статистические данные по судебно-экспертной, исследовательской, испытательной деятельности и состоянию кадров судебно-экспертных учреждений федеральной противопожарной службы «Испытательная пожарная лаборатория» за 2019 год. Проведено сравнение основных показателей деятельности за 2019 год с аналогичными показателями за 2018 год.
There are presented basic statistics relating to judicial-expert, research and testing activities as well as mastering new types of equipment, the state of personnel in judicial-expert establishments of the Federal Fire Service Fire-Testing Laboratory for 2019. Comparison between the basic indices of laboratories activities for 2019 and similar indices for 2018 is carried out.
Jinekolojik Kanserde Evde Bakım ve Teknoloji Kullanımı
Authors: BULUT Özlem Ülkü , KAPLAN Sena , ŞAHİN Sevil 
Published: September 2020

Jinekolojik kanserler dünyada ve ülkemizde hızla yaygınlaşmaktadır. Jinekolojik kanserli bireyler tedavi süreçlerinde oldukça zorlu yollardan geçmektedirler. Bu durum bireylerin yaşam kalitesini etkilemekte, sosyal etkileşimini azaltmakta, hastalığa uyumunu güçleştirmektedir. Hastalar evde bakım sürecinde hastalığın seyri hakkında bilgi sahibi olmak isterken, aynı zamanda sağlık kuruluşuna ulaşmakta da zorluk yaşayabilmektedirler.
Kanser tedavisinde kullanılan cerrahi girişimler, kemoterapi, radyoterapi, brakiterapi gibi uygulamalar hastaların bu süreci yönetebilmeleri için profesyonel danışmanlığa gereksinim duymalarına sebep olmaktadır. Kanser tedavisinde kullanılan bu yöntemlerin oldukça fazla komplikasyonu gelişebilmektedir. Bu komplikasyonların etkin yönetilebilmesi açısından hemşirelik bakımına ihtiyaç vardır. Hastaların katkıda bulunulacağı fiziksel-ruhsal ve sosyal olarak iyilik hallerinin değerlendirilmesi ve profesyonel danışmanlık alabilmeleri için evde bakım hizmetlerinde hemşirelik bakımı çok önemlidir.
Evde bakım uygulamalarını kolaylaştırmak için küreselleşen dünyada bilişim teknolojileriyle sağlık hizmetleri uzaktan verilebilmektedir. Evde bakımın öneminin anlaşıldığı ve giderek yaygınlaştığı bu dönemde tele-hemşirelik uygulamaları ihtiyaç haline gelmiştir. Hemşirelerin bu alanda nitelikli olarak yetişmesi, güncel gelişmeleri takip etmesi ve bireylere danışmanlık verebilmesi, evde bakımın etkinliği açısından büyük önem arz etmektedir. Bu derlemede jinekolojik kanserli bireylerin evde bakımında teknoloji kullanımının ve hemşirelik bakımının önemine değinilmiştir.
A Gaia Survey for Young Stars Associated with the Lupus Clouds*
Authors: Luhman K. L. 
Published: September 2020

Abstract
I have used high-precision photometry and astrometry from the second data release of the Gaia mission to perform a survey for young stars associated with the Lupus clouds, which have distances of ∼160 pc and reside within the Scorpius-Centaurus (Sco-Cen) OB association. The Gaia data have made it possible to distinguish Lupus members from most of the stars in other groups in Sco-Cen that overlap with the Lupus clouds, which have contaminated previous surveys. The new catalog of candidate Lupus members should be complete for spectral types earlier than M7 at A

K
< 0.2 within fields encompassing clouds 1–4. I have used that catalog to characterize various aspects of the Lupus stellar population. For instance, the sequence of low-mass stars in Lupus is ∼0.4 mag brighter than the sequence for Upper Sco, which implies an age of ∼6 Myr based an adopted age of 10–12 Myr for Upper Sco and the change in luminosity with age predicted by evolutionary models. I also find that the initial mass function in Lupus is similar to that in other nearby star-forming regions based on a comparison of their distributions of spectral types.
Multiwavelength Observation of a Failed Eruption from a Helical Kink-unstable Prominence
Authors: Xu Haiqing , Su Jiangtao , Chen Jie , Ruan Guiping , Awasthi Arun Kumar , Zhang Hongqi , Zhang Mei , Ji Kaifan , Zhang Yuzong , Liu Jiajia 
Published: September 2020

Abstract
Multiwavelength observations of a prominence eruption provide an opportunity to uncover the physical mechanism of the triggering and the evolution process of the eruption. In this paper, we investigate a prominence that erupted on 2012 October 14, recorded in Hα, EUV, and X-ray wavelengths. The process of the eruption gives evidence for the existence of a helical magnetic structure showing the twist converting to writhe. The estimated twist is

(three turns), exceeding the threshold of the kink instability. The rising plasma reached a high speed of 228 km s−1, followed by a sudden rapid acceleration of 2715 m s−2, and was synchronous with a solar flare. Co-spatial cusp-shaped structures were observed in both 131 and 94 Å images from the Atmospheric Imaging Assembly, signifying the location of the magnetic reconnection. The erupted flux rope finally underwent a deceleration with a maximum value of 391 m s−2, which is larger than the freefall acceleration on the Sun (273 m s−2), suggesting that the eruption finally failed, possibly due to an inward magnetic tension force.
Uncovering the Primary X-Ray Emission and Possible Starburst Component in the Polarized NLS1 Mrk 1239
Authors: Buhariwalla Margaret Z. , Waddell Sophia G. H. , Gallo Luigi C. , Grupe Dirk , Komossa S. 
Published: September 2020

Abstract
X-ray observations of the unique NLS1 galaxy Mrk 1239 spanning 18 yr are presented. Data from XMM-Newton, Suzaku, Swift, and NuSTAR are combined to obtain a broadband, multi-epoch view of the source. There is spectral variability in the 3–10 keV band over the 18 yr. An analysis of the NuSTAR and Suzaku lightcurves also suggests rapid variability in the 3–10 keV band, which is consistent with the NLS1 definition of the source. However, no variability is seen below 3 keV on any timescale. Two distinct physical models are adopted to describe the data above and below

. The low energies are dominated by a hot, diffuse gas likely associated with a starburst component at large physical scales. The higher-energy spectrum is dominated by emission from the central region. Ionized partial covering and relativistic blurred reflection are considered for the central region emission. In both cases, the underlying power law has a photon index of Γ ∼ 2.3–2.4. A distant reflector, a neutral partial covering component with a covering fraction near ∼1, and contributions from starburst emission are always required. The blurred reflection model requires a reflection-dominated spectrum, which may be at odds with the low emissivity index and radio properties of the source. By contrast, the two absorption components required in the ionized partial covering model may correspond to the two distinct regions of polarization observed in the optical. Regardless of the physical model, spectral changes between epochs are driven by the absorption components—and on short timescales, by intrinsic active galactic nucleus variability.
LB-1 Is Inconsistent with the X-Ray Source Population and Pulsar–Black Hole Binary Searches in the Milky Way
Authors: Safarzadeh Mohammadtaher , Ramirez-Ruiz Enrico , Kilpatrick Charles 
Published: September 2020

Abstract
If confirmed, a wide binary system consisting of a 70 M
⊙ black hole (BH) and an 8 M
⊙ main-sequence star (LB-1) is observed to reside in the Milky Way (MW). While we remain agnostic about the nature of LB-1, we show that long-term evolution of an 8 M
⊙ star around a BH with mass between 5 and 70 M
⊙ makes them visible as ultraluminous X-ray (ULX) sources in the sky. Given the expected ULX phase lifetime (≈0.1 Myr) and their lack of detection in the MW, we conclude that the frequency of an 8–20 M
⊙ star to be in binary around a stellar mass BH should be less (f < 4 × 10−3). This is in tension with Liu et al., who claimed the detection frequency of an LB-1-like system to be around 8–20 M
⊙ stars (f ≈ 3 × 10−2). Moreover, the 8 M
⊙ star is likely to end as a neutron star (NS) born with a very small kick from an electron-capture supernova (ECSN), leaving behind a wide NS–BH binary. So far, less than 1% of all the detectable pulsars in the MW have been mapped and there has been no detection of any pulsars in binary systems around BHs, which sets an upper bound of about 100 possible pulsar–BH systems in the MW. We show whether the NS is born from ECSN, a frequency upper limit of (f ≈ 10−3) for stars with masses ≈8–20 M
⊙ in the MW to have a BH companion. The rate discrepancy will further increase as more pulsars are mapped in the MW, yet these searches would not be able to rule out the Liu et al. detection frequency if NSs are instead born in core collapse SNe with the commonly inferred high kick velocities.
Elimination of the Blue Loops in the Evolution of Intermediate-mass Stars by the Neutrino Magnetic Moment and Large Extra Dimensions
Authors: Mori Kanji , Balantekin A. Baha , Kajino Toshitaka , Famiano Michael A. 
Published: September 2020

Abstract
For searching beyond Standard Model physics, stars are laboratories that complement terrestrial experiments. Massless neutrinos in the Standard Model of particle physics cannot have a magnetic moment, but massive neutrinos have a finite magnetic moment in the minimal extension of the Standard Model. Large extra dimensions (LEDs) are a possible solution of the hierarchy problem. Both of these provide additional energy-loss channels in stellar interiors via the electromagnetic interaction and radiation into extra dimensions, respectively, and thus affect stellar evolution. We perform simulations of stellar evolution with such additional energy losses and find that they eliminate the blue loops in the evolution of intermediate-mass stars. The existence of Cepheid stars can be used to constrain the neutrino magnetic moment (NMM) and LEDs. In order for Cepheids to exist, the NMM should be smaller than the range ∼2 × 10−10
μ
B–4 × 10−11
μ
B, where μ
B is the Bohr magneton, and the fundamental scale in the (4+2)-spacetime should be larger than ∼2–5 TeV, depending on the rate of the 12C

reaction. The fundamental scale also has strong dependence on the metallicity. This value of the magnetic moment is in the range explored in the reactor experiments, but higher than the limit inferred from globular clusters. Similarly the fundamental scale value we constrain corresponds to a size of the compactified dimensions comparable to those explored in the torsion balance experiments, but it is smaller than the limits inferred from collider experiments and low-mass stars.
The Spectroscopic Follow-up of the QUBRICS Bright Quasar Survey
Authors: Boutsia Konstantina , Grazian Andrea , Calderone Giorgio , Cristiani Stefano , Cupani Guido , Guarneri Francesco , Fontanot Fabio , Amorin Ricardo , D’Odorico Valentina , Giallongo Emanuele , Salvato Mara , Omizzolo Alessandro , Romano Michael , Menci Nicola 
Published: September 2020

Abstract
We present the results of the spectroscopic follow-up of the QUasars as BRIght beacons for Cosmology in the Southern Hemisphere (QUBRICS; Calderone et al. 2019) survey. The selection method is based on a machine-learning approach applied to photometric catalogs, covering an area of ∼12,400 deg2 in the Southern Hemisphere. The spectroscopic observations started in 2018 and identified 55 new, high-redshift (z ≥ 2.5), bright (i ≤ 18) quasi-stellar objects (QSOs), with the catalog published in late 2019. Here we report the current status of the survey, bringing the total number of bright QSOs at z ≥ 2.5 identified by QUBRICS to 224. The success rate of the QUBRICS selection method, in its most recent training, is estimated to be 68%. The predominant contaminant turns out to be lower-z QSOs at z < 2.5. This survey provides a unique sample of bright QSOs at high z available for a number of cosmological investigations. In particular, carrying out the redshift drift measurements (Sandage Test) in the Southern Hemisphere, using the High Resolution Spectrograph at the 39 m Extremely Large Telescope appears to be possible with less than 2500 hr of observations spread over 30 targets in 25 yr.