bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuromorphic van der Waals crystals for substantial energy generation
Authors: Kim Sungsoon , Choi Sangjin , Lee Hae Gon , Jin Dana , Kim Gwangmook , Kim Taehoon , Lee Joon Sang , Shim Wooyoung 
Published: January 2021

AbstractControlling ion transport in nanofluidics is fundamental to water purification, bio-sensing, energy storage, energy conversion, and numerous other applications. For any of these, it is essential to design nanofluidic channels that are stable in the liquid phase and enable specific ions to pass. A human neuron is one such system, where electrical signals are transmitted by cation transport for high-speed communication related to neuromorphic computing. Here, we present a concept of neuro-inspired energy harvesting that uses confined van der Waals crystal and demonstrate a method to maximise the ion diffusion flux to generate an electromotive force. The confined nanochannel is robust in liquids as in neuron cells, enabling steady-state ion diffusion for hundred of hours and exhibiting ion selectivity of 95.8%, energy conversion efficiency of 41.4%, and power density of 5.26 W/m2. This fundamental understanding and rational design strategy can enable previously unrealisable applications of passive-type large-scale power generation.
A cooperative biphasic MoOx–MoPx promoter enables a fast-charging lithium-ion battery
Authors: Lee Sang-Min , Kim Junyoung , Moon Janghyuk , Jung Kyu-Nam , Kim Jong Hwa , Park Gum-Jae , Choi Jeong-Hee , Rhee Dong Young , Kim Jeom-Soo , Lee Jong-Won , Park Min-Sik 
Published: January 2021

AbstractThe realisation of fast-charging lithium-ion batteries with long cycle lifetimes is hindered by the uncontrollable plating of metallic Li on the graphite anode during high-rate charging. Here we report that surface engineering of graphite with a cooperative biphasic MoOx–MoPx promoter improves the charging rate and suppresses Li plating without compromising energy density. We design and synthesise MoOx–MoPx/graphite via controllable and scalable surface engineering, i.e., the deposition of a MoOx nanolayer on the graphite surface, followed by vapour-induced partial phase transformation of MoOx to MoPx. A variety of analytical studies combined with thermodynamic calculations demonstrate that MoOx effectively mitigates the formation of resistive films on the graphite surface, while MoPx hosts Li+ at relatively high potentials via a fast intercalation reaction and plays a dominant role in lowering the Li+ adsorption energy. The MoOx–MoPx/graphite anode exhibits a fast-charging capability (<10 min charging for 80% of the capacity) and stable cycling performance without any signs of Li plating over 300 cycles when coupled with a LiNi0.6Co0.2Mn0.2O2 cathode. Thus, the developed approach paves the way to the design of advanced anode materials for fast-charging Li-ion batteries.
Bariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells
Authors: Ribeiro-Parenti Lara , Jarry Anne-Charlotte , Cavin Jean-Baptiste , Willemetz Alexandra , Le Beyec Johanne , Sannier Aurélie , Benadda Samira , Pelletier Anne-Laure , Hourseau Muriel , Léger Thibaut , Morlet Bastien , Couvelard Anne , Anini Younes , Msika Simon , Marmuse Jean-Pierre , Ledoux Sévérine , Le Gall Maude , Bado André 
Published: January 2021

AbstractGlucagon-Like Peptide-1 (GLP-1) undergoes rapid inactivation by dipeptidyl peptidase-4 (DPP4) suggesting that target receptors may be activated by locally produced GLP-1. Here we describe GLP-1 positive cells in the rat and human stomach and found these cells co-expressing ghrelin or somatostatin and able to secrete active GLP-1 in the rats. In lean rats, a gastric load of glucose induces a rapid and parallel rise in GLP-1 levels in both the gastric and the portal veins. This rise in portal GLP-1 levels was abrogated in HFD obese rats but restored after vertical sleeve gastrectomy (VSG) surgery. Finally, obese rats and individuals operated on Roux-en-Y gastric bypass and SG display a new gastric mucosa phenotype with hyperplasia of the mucus neck cells concomitant with increased density of GLP-1 positive cells. This report brings to light the contribution of gastric GLP-1 expressing cells that undergo plasticity changes after bariatric surgeries, to circulating GLP-1 levels.
The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus
Authors: Karimi Mohammad M. , Guo Ya , Cui Xiaokai , Pallikonda Husayn A. , Horková Veronika , Wang Yi-Fang , Gil Sara Ruiz , Rodriguez-Esteban Gustavo , Robles-Rebollo Irene , Bruno Ludovica , Georgieva Radina , Patel Bhavik , Elliott James , Dore Marian H. , Dauphars Danielle , Krangel Michael S. , Lenhard Boris , Heyn Holger , Fisher Amanda G. , Štěpánek Ondřej , Merkenschlager Matthias 
Published: January 2021

AbstractCD4 and CD8 mark helper and cytotoxic T cell lineages, respectively, and serve as coreceptors for MHC-restricted TCR recognition. How coreceptor expression is matched with TCR specificity is central to understanding CD4/CD8 lineage choice, but visualising coreceptor gene activity in individual selection intermediates has been technically challenging. It therefore remains unclear whether the sequence of coreceptor gene expression in selection intermediates follows a stereotypic pattern, or is responsive to signaling. Here we use single cell RNA sequencing (scRNA-seq) to classify mouse thymocyte selection intermediates by coreceptor gene expression. In the unperturbed thymus, Cd4+Cd8a- selection intermediates appear before Cd4-Cd8a+ selection intermediates, but the timing of these subsets is flexible according to the strength of TCR signals. Our data show that selection intermediates discriminate MHC class prior to the loss of coreceptor expression and suggest a model where signal strength informs the timing of coreceptor gene activity and ultimately CD4/CD8 lineage choice.
Simultaneous Zn2+ tracking in multiple organelles using super-resolution morphology-correlated organelle identification in living cells
Authors: Fang Hongbao , Geng Shanshan , Hao Mingang , Chen Qixin , Liu Minglun , Liu Chunyan , Tian Zhiqi , Wang Chengjun , Takebe Takanori , Guan Jun-Lin , Chen Yuncong , Guo Zijian , He Weijiang , Diao Jiajie 
Published: January 2021

AbstractZn2+ plays important roles in metabolism and signaling regulation. Subcellular Zn2+ compartmentalization is essential for organelle functions and cell biology, but there is currently no method to determine Zn2+ signaling relationships among more than two different organelles with one probe. Here, we report simultaneous Zn2+ tracking in multiple organelles (Zn-STIMO), a method that uses structured illumination microscopy (SIM) and a single Zn2+ fluorescent probe, allowing super-resolution morphology-correlated organelle identification in living cells. To guarantee SIM imaging quality for organelle identification, we develop a new turn-on Zn2+ fluorescent probe, NapBu-BPEA, by regulating the lipophilicity of naphthalimide-derived Zn2+ probes to make it accumulate in multiple organelles except the nucleus. Zn-STIMO with this probe shows that CCCP-induced mitophagy in HeLa cells is associated with labile Zn2+ enhancement. Therefore, direct organelle identification supported by SIM imaging makes Zn-STIMO a reliable method to determine labile Zn2+ dynamics in various organelles with one probe. Finally, SIM imaging of pluripotent stem cell-derived organoids with NapBu-BPEA demonstrates the potential of super-resolution morphology-correlated organelle identification to track biospecies and events in specific organelles within organoids.
Epidemic growth and Griffiths effects on an emergent network of excited atoms
Authors: Wintermantel T. M. , Buchhold M. , Shevate S. , Morgado M. , Wang Y. , Lochead G. , Diehl S. , Whitlock S. 
Published: January 2021

AbstractWhether it be physical, biological or social processes, complex systems exhibit dynamics that are exceedingly difficult to understand or predict from underlying principles. Here we report a striking correspondence between the excitation dynamics of a laser driven gas of Rydberg atoms and the spreading of diseases, which in turn opens up a controllable platform for studying non-equilibrium dynamics on complex networks. The competition between facilitated excitation and spontaneous decay results in sub-exponential growth of the excitation number, which is empirically observed in real epidemics. Based on this we develop a quantitative microscopic susceptible-infected-susceptible model which links the growth and final excitation density to the dynamics of an emergent heterogeneous network and rare active region effects associated to an extended Griffiths phase. This provides physical insights into the nature of non-equilibrium criticality in driven many-body systems and the mechanisms leading to non-universal power-laws in the dynamics of complex systems.
Cardiomyocytes stimulate angiogenesis after ischemic injury in a ZEB2-dependent manner
Authors: Gladka Monika M. , Kohela Arwa , Molenaar Bas , Versteeg Danielle , Kooijman Lieneke , Monshouwer-Kloots Jantine , Kremer Veerle , Vos Harmjan R. , Huibers Manon M. H. , Haigh Jody J. , Huylebroeck Danny , Boon Reinier A. , Giacca Mauro , van Rooij Eva 
Published: January 2021

AbstractThe disruption in blood supply due to myocardial infarction is a critical determinant for infarct size and subsequent deterioration in function. The identification of factors that enhance cardiac repair by the restoration of the vascular network is, therefore, of great significance. Here, we show that the transcription factor Zinc finger E-box-binding homeobox 2 (ZEB2) is increased in stressed cardiomyocytes and induces a cardioprotective cross-talk between cardiomyocytes and endothelial cells to enhance angiogenesis after ischemia. Single-cell sequencing indicates ZEB2 to be enriched in injured cardiomyocytes. Cardiomyocyte-specific deletion of ZEB2 results in impaired cardiac contractility and infarct healing post-myocardial infarction (post-MI), while cardiomyocyte-specific ZEB2 overexpression improves cardiomyocyte survival and cardiac function. We identified Thymosin β4 (TMSB4) and Prothymosin α (PTMA) as main paracrine factors released from cardiomyocytes to stimulate angiogenesis by enhancing endothelial cell migration, and whose regulation is validated in our in vivo models. Therapeutic delivery of ZEB2 to cardiomyocytes in the infarcted heart induces the expression of TMSB4 and PTMA, which enhances angiogenesis and prevents cardiac dysfunction. These findings reveal ZEB2 as a beneficial factor during ischemic injury, which may hold promise for the identification of new therapies.
Real-time multispeckle spectral-temporal measurement unveils the complexity of spatiotemporal solitons
Authors: Guo Yuankai , Wen Xiaoxiao , Lin Wei , Wang Wenlong , Wei Xiaoming , Yang Zhongmin 
Published: January 2021

AbstractThe dynamics of three-dimensional (3D) dissipative solitons originated from spatiotemporal interactions share many common characteristics with other multi-dimensional phenomena. Unveiling the dynamics of 3D solitons thus permits new routes for tackling multidisciplinary nonlinear problems and exploiting their instabilities. However, this remains an open challenge, as they are multi-dimensional, stochastic and non-repeatable. Here, we report the real-time speckle-resolved spectral-temporal dynamics of a 3D soliton laser using a single-shot multispeckle spectral-temporal technology that leverages optical time division multiplexing and photonic time stretch. This technology enables the simultaneous observation on multiple speckle grains to provide long-lasting evolutionary dynamics on the planes of cavity time (t) – roundtrip and spectrum (λ) – roundtrip. Various non-repeatable speckly-diverse spectral-temporal dynamics are discovered in both the early and established stages of the 3D soliton formation.
Mitochondrial health is enhanced in rats with higher vs. lower intrinsic exercise capacity and extended lifespan
Authors: Aon Miguel A. , Cortassa Sonia , Juhaszova Magdalena , González-Reyes José A. , Calvo-Rubio Miguel , Villalba José M. , Lachance Andrew D. , Ziman Bruce D. , Mitchell Sarah J. , Murt Kelsey N. , Axsom Jessie E. C. , Alfaras Irene , Britton Steven L. , Koch Lauren G. , de Cabo Rafael , Lakatta Edward G. , Sollott Steven J. 
Published: January 2021

AbstractThe intrinsic aerobic capacity of an organism is thought to play a role in aging and longevity. Maximal respiratory rate capacity, a metabolic performance measure, is one of the best predictors of cardiovascular- and all-cause mortality. Rats selectively bred for high-(HCR) vs. low-(LCR) intrinsic running-endurance capacity have up to 31% longer lifespan. We found that positive changes in indices of mitochondrial health in cardiomyocytes (respiratory reserve, maximal respiratory capacity, resistance to mitochondrial permeability transition, autophagy/mitophagy, and higher lipids-over-glucose utilization) are uniformly associated with the extended longevity in HCR vs. LCR female rats. Cross-sectional heart metabolomics revealed pathways from lipid metabolism in the heart, which were significantly enriched by a select group of strain-dependent metabolites, consistent with enhanced lipids utilization by HCR cardiomyocytes. Heart–liver–serum metabolomics further revealed shunting of lipidic substrates between the liver and heart via serum during aging. Thus, mitochondrial health in cardiomyocytes is associated with extended longevity in rats with higher intrinsic exercise capacity and, probably, these findings can be translated to other populations as predictors of outcomes of health and survival.
Cobalt-based magnetic Weyl semimetals with high-thermodynamic stabilities
Authors: Luo Wei , Nakamura Yuma , Park Jinseon , Yoon Mina 
Published: January 2021

AbstractRecent experiments identified Co3Sn2S2as the first magnetic Weyl semimetal (MWSM). Using first-principles calculation with a global optimization approach, we explore the structural stabilities and topological electronic properties of cobalt (Co)-based shandite and alloys, Co3MM’X2(M/M’ = Ge, Sn, Pb, X = S, Se, Te), and identify stable structures with different Weyl phases. Using a tight-binding model, for the first time, we reveal that the physical origin of the nodal lines of a Co-based shandite structure is the interlayer coupling between Co atoms in different Kagome layers, while the number of Weyl points and their types are mainly governed by the interaction between Co and the metal atoms, Sn, Ge, and Pb. The Co3SnPbS2alloy exhibits two distinguished topological phases, depending on the relative positions of the Sn and Pb atoms: a three-dimensional quantum anomalous Hall metal, and a MWSM phase with anomalous Hall conductivity (~1290 Ω−1 cm−1) that is larger than that of Co2Sn2S2. Our work reveals the physical mechanism of the origination of Weyl fermions in Co-based shandite structures and proposes topological quantum states with high thermal stability.
Electron correlation effects on exchange interactions and spin excitations in 2D van der Waals materials
Authors: Ke Liqin , Katsnelson Mikhail I. 
Published: January 2021

AbstractDespite serious effort, the nature of the magnetic interactions and the role of electron-correlation effects in magnetic two-dimensional (2D) van der Waals materials remains elusive. Using CrI3 as a model system, we show that the calculated electronic structure including nonlocal electron correlations yields spin excitations consistent with inelastic neutron-scattering measurements. Remarkably, this approach identifies an unreported correlation-enhanced interlayer super-superexchange, which rotates the magnon Dirac lines off, and introduces a gap along the high-symmetry Γ-K-M path. This discovery provides a different perspective on the gap-opening mechanism observed in CrI3, which was previously associated with spin–orbit coupling through the Dzyaloshinskii–Moriya interaction or Kitaev interaction. Our observation elucidates the critical role of electron correlations on the spin ordering and spin dynamics in magnetic van der Waals materials and demonstrates the necessity of explicit treatment of electron correlations in the broad family of 2D magnetic materials.
Plasma-borne indicators of inflammasome activity in Parkinson’s disease patients
Authors: Anderson Faith L. , von Herrmann Katharine M. , Andrew Angeline S. , Kuras Yuliya I. , Young Alison L. , Scherzer Clemens R. , Hickey William F. , Lee Stephen L. , Havrda Matthew C. 
Published: January 2021

AbstractParkinson’s disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms and loss of dopaminergic neurons of the substantia nigra. Inflammation and cell death are recognized aspects of PD suggesting that strategies to monitor and modify these processes may improve the management of the disease. Inflammasomes are pro-inflammatory intracellular pattern recognition complexes that couple these processes. The NLRP3 inflammasome responds to sterile triggers to initiate pro-inflammatory processes characterized by maturation of inflammatory cytokines, cytoplasmic membrane pore formation, vesicular shedding, and if unresolved, pyroptotic cell death. Histologic analysis of tissues from PD patients and individuals with nigral cell loss but no diagnosis of PD identified elevated expression of inflammasome-related proteins and activation-related “speck” formation in degenerating mesencephalic tissues compared with controls. Based on previous reports of circulating inflammasome proteins in patients suffering from heritable syndromes caused by hyper-activation of the NLRP3 inflammasome, we evaluated PD patient plasma for evidence of inflammasome activity. Multiple circulating inflammasome proteins were detected almost exclusively in extracellular vesicles indicative of ongoing inflammasome activation and pyroptosis. Analysis of plasma obtained from a multi-center cohort identified elevated plasma-borne NLRP3 associated with PD status. Our findings are consistent with others indicating inflammasome activity in neurodegenerative disorders. Findings suggest mesencephalic inflammasome protein expression as a histopathologic marker of early-stage nigral degeneration and suggest plasma-borne inflammasome-related proteins as a potentially useful class of biomarkers for patient stratification and the detection and monitoring of inflammation in PD.
Feasibility of satellite-to-ground continuous-variable quantum key distribution
Authors: Dequal Daniele , Trigo Vidarte Luis , Roman Rodriguez Victor , Vallone Giuseppe , Villoresi Paolo , Leverrier Anthony , Diamanti Eleni 
Published: January 2021

AbstractEstablishing secure communication links at a global scale is a major potential application of quantum information science but also extremely challenging for the underlying technology. Although milestone experiments using satellite-to-ground links and exploiting singe-photon encoding for implementing quantum key distribution have shown recently that this goal is achievable, it is still necessary to further investigate practical solutions compatible with classical optical communication systems. Here, we examine the feasibility of establishing secret keys in a satellite-to-ground downlink configuration using continuous-variable encoding, which can be implemented using standard telecommunication components certified for space environment and able to operate at high symbol rates. Considering a realistic channel model and state-of-the-art technology, and exploiting an orbit subdivision technique for mitigating fluctuations in the transmission efficiency, we find positive secret key rates for a low-Earth-orbit scenario, whereas finite-size effects can be a limiting factor for higher orbits. Our analysis determines regions of values for important experimental parameters where secret key exchange is possible and can be used as a guideline for experimental efforts in this direction.
A polarization encoded photon-to-spin interface
Authors: Chen K. C. , Bersin E. , Englund D. 
Published: January 2021

AbstractWe propose an integrated photonics device for mapping qubits encoded in the polarization of a photon onto the spin state of a solid-state defect coupled to a photonic crystal cavity: a “polarization-encoded photon-to-spin interface” (PEPSI). We perform a theoretical analysis of the state fidelity’s dependence on the device’s polarization extinction ratio and atom–cavity cooperativity. Furthermore, we explore the rate-fidelity trade-off through analytical and numerical models. In simulation, we show that our design enables efficient, high fidelity photon-to-spin mapping.
The bulk-corner correspondence of time-reversal symmetric insulators
Authors: Kooi Sander , van Miert Guido , Ortix Carmine 
Published: January 2021

AbstractThe topology of insulators is usually revealed through the presence of gapless boundary modes: this is the so-called bulk-boundary correspondence. However, the many-body wavefunction of a crystalline insulator is endowed with additional topological properties that do not yield surface spectral features, but manifest themselves as (fractional) quantized electronic charges localized at the crystal boundaries. Here, we formulate such bulk-corner correspondence for the physical relevant case of materials with time-reversal symmetry and spin-orbit coupling. To do so we develop partial real-space invariants that can be neither expressed in terms of Berry phases nor using symmetry-based indicators. These previously unknown crystalline invariants govern the (fractional) quantized corner charges both of isolated material structures and of heterostructures without gapless interface modes. We also show that the partial real-space invariants are able to detect all time-reversal symmetric topological phases of the recently discovered fragile type.
Bio-artificial pleura using autologous dermal fibroblast sheets to mitigate air leaks during thoracoscopic lung resection
Authors: Kanzaki Masato , Takagi Ryo , Washio Kaoru , Kokubo Mami , Mitsuboshi Shota , Isaka Tamami , Yamato Masayuki 
Published: January 2021

AbstractLung air leaks (LALs) due to visceral pleura injury during surgery are a difficult-to-avoid complication in thoracic surgery (TS). Reliable LAL closure is an important patient management issue after TS. We demonstrated both safeties of transplantation of a cultured human autologous dermal fibroblast sheet (DFS) to LALs. From May 2016 to March 2018, five patients who underwent thoracoscopic lung resection met all the inclusion criteria. Skin biopsies were acquired from each patient to source autologous dermal cells for DFS fabrication. During the primary culture, fibroblasts migrated from the dermal tissue pieces and proliferated to form cell monolayers. These fibroblasts were subcultured to confluence. Transplantable DFSs were fabricated from these subcultured fibroblasts that were trypsinized and seeded onto temperature-responsive culture dishes. After 10 days of fabrication culture, intact patient-specific DFS were harvested. DFSs were analyzed for fibroblast cell content and tissue contaminants prior to application. For closing intraoperative LAL, mean number of transplanted autologous DFS per patient was 6 ± 2 sheets. Mean chest drainage duration was 5.0 ± 4.8 days. The two patients with major LAL had a drainage duration of more than 7 days. All patients currently have no LAL recurrence after discharge. DFSs effectively maintain LAL closure via remodeling of the deposited extracellular matrix. The use of autologous DFSs to permanently close air leaks using a patient-derived source is expected to reduce surgical complications during high-risk lung resections.