bluuebunny/crossref_metadata_2025_split huggingface dataset:
New fluid biomarkers tracking non-amyloid-β and non-tau pathology in Alzheimer’s disease
Authors: Park Sun Ah , Han Song Mi , Kim Chae Eun 
Published: April 2020

AbstractCerebrospinal fluid (CSF) biomarkers based on the core pathological proteins associated with Alzheimer’s disease (AD), i.e., amyloid-β (Aβ) and tau protein, are widely regarded as useful diagnostic biomarkers. However, a lack of biomarkers for monitoring the treatment response and indexing clinical severity has proven to be problematic in drug trials targeting Aβ. Therefore, new biomarkers are needed to track non-Aβ and non-tau pathology. Many proteins involved in the pathophysiological progression of AD have shown promise as new biomarkers. Neurodegeneration- and synapse-related biomarkers in CSF (e.g., neurofilament light polypeptide [NFL], neurogranin, and visinin-like protein 1) and blood (e.g., NFL) aid prediction of AD progress, as well as early diagnosis. Neuroinflammation, lipid dysmetabolism, and impaired protein clearance are considered important components of AD pathophysiology. Inflammation-related proteins in the CSF, such as progranulin, intercellular adhesion molecule 1, and chitinase-3-like protein 1 (YKL-40), are useful for the early detection of AD and can represent clinical severity. Several lipid metabolism-associated biomarkers and protein clearance-linked markers have also been suggested as candidate AD biomarkers. Combinations of subsets of new biomarkers enhance their utility in terms of broadly characterizing AD-associated pathological changes, thereby facilitating precise selection of susceptible patients and comprehensive monitoring of the treatment response. This approach could facilitate the development of effective treatments for AD.
Performing optical logic operations by a diffractive neural network
Authors: Qian Chao , Lin Xiao , Lin Xiaobin , Xu Jian , Sun Yang , Li Erping , Zhang Baile , Chen Hongsheng 
Published: April 2020

AbstractOptical logic operations lie at the heart of optical computing, and they enable many applications such as ultrahigh-speed information processing. However, the reported optical logic gates rely heavily on the precise control of input light signals, including their phase difference, polarization, and intensity and the size of the incident beams. Due to the complexity and difficulty in these precise controls, the two output optical logic states may suffer from an inherent instability and a low contrast ratio of intensity. Moreover, the miniaturization of optical logic gates becomes difficult if the extra bulky apparatus for these controls is considered. As such, it is desirable to get rid of these complicated controls and to achieve full logic functionality in a compact photonic system. Such a goal remains challenging. Here, we introduce a simple yet universal design strategy, capable of using plane waves as the incident signal, to perform optical logic operations via a diffractive neural network. Physically, the incident plane wave is first spatially encoded by a specific logic operation at the input layer and further decoded through the hidden layers, namely, a compound Huygens’ metasurface. That is, the judiciously designed metasurface scatters the encoded light into one of two small designated areas at the output layer, which provides the information of output logic states. Importantly, after training of the diffractive neural network, all seven basic types of optical logic operations can be realized by the same metasurface. As a conceptual illustration, three logic operations (NOT, OR, and AND) are experimentally demonstrated at microwave frequencies.
Measurement and microscopic description of odd–even staggering of charge radii of exotic copper isotopes
Authors: de Groote R. P. , Billowes J. , Binnersley C. L. , Bissell M. L. , Cocolios T. E. , Day Goodacre T. , Farooq-Smith G. J. , Fedorov D. V. , Flanagan K. T. , Franchoo S. , Garcia Ruiz R. F. , Gins W. , Holt J. D. , Koszorús Á. , Lynch K. M. , Miyagi T. , Nazarewicz W. , Neyens G. , Reinhard P.-G. , Rothe S. , Stroke H. H. , Vernon A. R. , Wendt K. D. A. , Wilkins S. G. , Xu Z. Y. , Yang X. F. 
Published: April 2020

AbstractNuclear charge radii globally scale with atomic mass number A as A1∕3, and isotopes with an odd number of neutrons are usually slightly smaller in size than their even-neutron neighbours. This odd–even staggering, ubiquitous throughout the nuclear landscape1, varies with the number of protons and neutrons, and poses a substantial challenge for nuclear theory2–4. Here, we report measurements of the charge radii of short-lived copper isotopes up to the very exotic 78Cu (with proton number Z = 29 and neutron number N = 49), produced at only 20 ions s–1, using the collinear resonance ionization spectroscopy method at the Isotope Mass Separator On-Line Device facility (ISOLDE) at CERN. We observe an unexpected reduction in the odd–even staggering for isotopes approaching the N = 50 shell gap. To describe the data, we applied models based on nuclear density functional theory5,6 and A-body valence-space in-medium similarity renormalization group theory7,8. Through these comparisons, we demonstrate a relation between the global behaviour of charge radii and the saturation density of nuclear matter, and show that the local charge radii variations, which reflect the many-body polarization effects, naturally emerge from A-body calculations fitted to properties of A ≤ 4 nuclei.
Preparing and Presenting Journal Club Content: An Essential Component of Homeopathic Learning
Authors: Dutta Abhijit , Ghosh Shubhamoy 
Published: April 2020

AbstractHomeopathic education has passed through significant incremental changes in the past few years, where especially postgraduate education has become increasingly slanted toward advanced knowledge of clinical work and research methods. Among many educational activities, a great source of learning is from presenting at or attending a journal club meeting, which is a gathering of people to learn and to critically appraise a journal article or other study material. There has been little previous guidance in homeopathy regarding how to prepare and present journal club content. Selection of a suitable topic is one of the critical prerequisites. Each and every step, from preparation to presentation, needs to be carefully planned and considered. For the meeting to be successful, the final discussion phase requires the active participation and critical insight of all those attending.
Fracture Toughness Comparison of Three Indirect Composite Resins Using 4-Point Flexural Strength Method
Authors: Moradi Zohreh , Abbasi Mahdi , Khalesi Rayhaneh , Tabatabaei Masoumeh Hasani , Shahidi Zahra 
Published: April 2020

Abstract
Objectives The advantages of indirect composite restorations such as less crack formation during their computer-aided design/computer-aided manufacturing process, compared with ceramic restorations, have resulted in their growing popularity. However, restoration failure is a major concern with regard to the long-term clinical success of restorations and may occur as the result of propagation of a crack originated from an internal flaw in the restoration. This study aimed to compare the fracture toughness of three indirect composite resins.
Materials and Methods In this in vitro experimental study, 10 specimens measuring 3 × 3 × 18 mm were fabricated of Gradia, Crios, and high impact polymer composite indirect composites. A single edge notch with a diameter < 0.3 mm and 0.3 mm length was created in the 9 mm longitudinal dimension of specimens using a no. 11 surgical scalpel. The specimens were then subjected to 4-point flexural strength test in a universal testing machine with a crosshead speed of 0.1 mm/s until failure.
Statistical Analysis Data were analyzed using IBM SPSS Statistics via one-way analysis of variance (ANOVA) and Tukey’s HSD (honestly significant difference) test. The statistical power was set at p ˂ 0.05.
Results One-way ANOVA showed a significant difference in fracture toughness of the three composite groups (p = 0.000). According to the Tukey HSD analysis, the fracture toughness of HIPC was significantly higher than that of the other two composites. The fracture toughness of Gradia was significantly lower among all.
Conclusions Within the limitations of this study, the results showed that high temperature-pressure polymerization can increase resistance to crack propagation and subsequently improve the clinical service of indirect composite restorations. Although we do not know the filler volume percentage of HIPC, it seems that filler volume percentage of the composite is inversely correlated with fracture toughness.
In Vivo Effects of a Hydroxyapatite-Based Oral Care Gel on the Calcium and Phosphorus Levels of Dental Plaque
Authors: Sudradjat Henny , Meyer Frederic , Loza Kateryna , Epple Matthias , Enax Joachim 
Published: April 2020

Abstract

Objectives Particulate hydroxyapatite (HAP; Ca5(PO4)3(OH)) is a biomimetic oral care ingredient. One mode of action in caries-susceptible individuals may be the adhesion/incorporation of HAP into dental plaque. Therefore, the aim of this in vivo study was to analyze the 3-day effects of a newly developed hydroxyapatite-based oral care gel on the calcium and phosphorus levels within the dental plaque of children.
Materials and Methods This study was conducted in Kebon Padangan at Bali in Indonesia. Thirty-four children (mean age, 8.9 years; mean DMF-T [decayed, missing, and filled teeth; permanent teeth], 0.6; mean dmft-t [primary teeth] 4.5) were included in the study. The gel was applied thrice for 3 days by an experienced dentist. Dental plaque was collected at baseline and after the study. Levels of calcium and phosphorus of plaque samples were analyzed by energy-dispersive X-ray spectroscopy.
Statistical Analysis Medians for both calcium and phosphorus levels were calculated (baseline and 3-day application of HAP-gel).
Results The calcium level increased after 3 days of application of the HAP-gel from 0.25 wt% (median) to 0.40 wt% (median), while the phosphorus level increased from 1.17 wt% (median) to 1.41 wt% (median). However, variations in both calcium and phosphorus levels measured in the pooled dental plaque samples were high.
Conclusion Within the limitations of the study, the 3-day application of the oral HAP-gel in children increased the median of both calcium and phosphorus levels in plaque. Consequently, a positive influence on the remineralization/demineralization process is very likely.
Qualitative Assessment of Four Types of Three-Dimensional Printed Anatomical Tibial Bone Models Compared to Commercially Available Models
Authors: Malek Sarah , Foster Cassandra D. , Huston Davin H. 
Published: April 2020

Abstract
Objective The aim of this study was to compare technical and physical features of four three-dimensional printed bone models used for teaching purposes to commercial models.
Study Design A canine tibia was imaged using computed tomography and used for model development. Tibial models were printed using Resin, polylactide acid (PLA), acrylonitrile butadiene styrene (ABS) and high-impact polystyrene (HIPS). They were compared with two commercial models (SAWBONES 2117 and 2108). Models were drilled in three locations and then cut transversely. Subjective quality of models, time and cost of production were compared.
Results Print time was approximately 3 hours for Resin and 4 hours for each of the PLA, ABS and HIPS models. Unlike the Resin and SAWBONES, the PLA, HIPS and ABS had higher heat generation during both drilling and cutting with mild construct deformation at cut surfaces in ABS and PLA models. Characteristics of real bone during drilling and cutting were best simulated in decreasing order by Resin, PLA, ABS and HIPS followed by SAWBONES 2117 and 2108 models. Material costs were $14.6 (Resin), $0.48 (PLA/ABS), $1.52 (HIPS), $23.50 and $17.50 for SAWBONES 2117 and 2108 per model, respectively. Resin performed best and had the closest subjective tactile properties to real bone.
Conclusion The three-dimensional printed tibial bone models provide a cost-effective alternative to commercially available bone models in veterinary medicine as teaching models.
Biomechanical Effects of Tibial Plateau Levelling Osteotomy on Joint Instability in Normal Canine Stifles: An In Vitro Study
Authors: Shimada Masakazu , Takagi Tetsuya , Kanno Nobuo , Yamakawa Satoshi , Fujie Hiromichi , Ichinohe Tom , Suzuki Shuji , Harada Yasuji , Hara Yasushi 
Published: April 2020

Abstract
Objective The aim of the study was to determine the changes in biomechanical characteristics following tibial plateau levelling osteotomy (TPLO) using simulated manual tests.
Study Design Twenty-one stifles from healthy Beagle dogs that had undergone TPLO or had not (control) were first tested in the intact form, and then the cranial cruciate ligament (CrCL) was transected in each to provide four test situations: control-intact, control-CrCL-transected, TPLO-intact and TPLO-CrCL-transected. The stifles were then analysed using a robotic joint biomechanical testing system. The craniocaudal drawer, axial rotation and proximal compression tests were applied.
Results The craniocaudal displacement during the drawer test was not significantly different between the control-intact and TPLO-intact. However, the displacement was significantly greater in the TPLO-CrCL-transected than in the control-intact. In the axial rotation test, the internal–external (IE) rotation was significantly greater in the TPLO-intact than in the control-intact. Similarly, the IE rotation was significantly greater in the TPLO-CrCL-transected than in the control-CrCL-transected. In the proximal compression test, craniocaudal displacement was not significantly different among the control-intact, TPLO-intact and TPLO-CrCL-transected.
Conclusion These findings suggest that TPLO influences the tension of the collateral ligaments and might generate laxity of the tibiofemoral joint. Instability after the osteotomy might be associated with the progression of osteoarthritis.
Cardiac Imaging—Physiologic Assessment of Coronary Artery Lesion
Authors: Jyotsna Maddury 
Published: April 2020

AbstractThirty percent of angiographically significant coronary lesions may be functionally significant. Physiological assessment is essential to treat intermediate coronary lesions before taking the decision for percutaneous intervention. Even when coronary artery bypass is planned as treatment modality in triple-vessel coronary artery disease, the SYNTEX II trial has shown that functionally significant lesion treatment by bypass grafts improves the outcome of these patients. In this article, possible ways of estimating the physiologic assessment of coronary lesion, and the advantages and disadvantages of methods of estimating the physiologic assessment of coronary lesions is discussed.
Left- and Right-Dislocation and the speaker’s perspective
Authors: Cardinaletti Anna 
Published: April 2020

Abstract
In Italian, topics appear in left- or right-dislocated position and are doubled by clause-internal clitic pronouns. In this paper, the syntax and the contribution to discourse of left- and right-dislocated topics are discussed. We focus on Familiar Topics, the only topic which can appear in either position. It is shown that Familiar Topics do not only involve the retrieval of given information, as is currently assumed, but also contribute to the conversational dynamics by adding the speaker’s perspective on shared information. It is also shown that left and right-dislocated topics have different properties, confirming that Left Dislocation is not the mirror image of Right Dislocation. The discussion includes the comparison between Italian Left and Right Dislocation and German modal particles.
Diagnosing verb raising
Authors: Tescari Neto Aquiles 
Published: April 2020

Abstract
Adverbs have been largely taken as diagnostics for movements. The enrichment of structures by the “Cartographic Program” brings about an important question to the theory of verb raising: which AdvPs should be considered reliable diagnostics? The paper brings data from Brazilian Portuguese and Peruvian Spanish to argue that low adverbs are bona fide diagnostics for verb raising. The position of the finite and the infinitive relative to the nine lowest adverbs of Cinque’s hierarchy in four possible orders is tested in these two languages. Data from BP, testing the position of high adverbs relative to the lexical verb, is presented in the sequence. Those data allow one to argue that high adverbs cannot be used as diagnostic tools for movements. Further data on VP-ellipsis confirms the contention that only low adverbs are bona fide diagnostics for V raising.
A Matter of the Heart: Daytime Relationship Functioning and Overnight Heart Rate in Young Dating Couples
Authors: Schacter Hannah L , Pettit Corey , Kim Yehsong , Sichko Stassja , Timmons Adela C , Chaspari Theodora , Han Sohyun C , Margolin Gayla 
Published: April 2020

Abstract

Background
Although past longitudinal research demonstrates that romantic partners affect one another’s health outcomes, considerably less is known about how romantic experiences “get under the skin” in everyday life.

Purpose
The current study investigated whether young couples’ naturally occurring feelings of closeness to and annoyance with each other during waking hours were associated with their overnight cardiovascular activity.

Methods
Participants were 63 heterosexual young adult dating couples (Mage = 23.07). Using ecological momentary assessments, couples reported their hourly feelings of closeness to and annoyance with their partners across 1 day; subsequent overnight heart rate was captured through wearable electrocardiogram biosensors. Actor–partner interdependence models tested whether individuals’ overnight heart rate varied as a function of (a) their own daytime feelings of closeness and annoyance (actor effects) and (b) their partner’s daytime feelings of closeness and annoyance (partner effects) while controlling for daytime heart rate.

Results
Although young adults’ feelings of romantic closeness and annoyance were unrelated to their own overnight heart rate (i.e., no actor effects), gender-specific partner effects emerged. Young men’s nocturnal heart rate was uniquely predicted by their female partner’s daytime relationship feelings. When women felt closer to their partners during the day, men exhibited lower overnight heart rate. When women felt more annoyed with their partners during the day, men exhibited heightened overnight heart rate.

Conclusions
The findings illustrate gender-specific links between couple functioning and physiological arousal in the everyday lives of young dating couples, implicating physiological sensitivity to partner experiences as one potential pathway through which relationships affect health.
Assessment of Specimen Pooling to Conserve SARS CoV-2 Testing Resources
Authors: Abdalhamid Baha , Bilder Christopher R , McCutchen Emily L , Hinrichs Steven H , Koepsell Scott A , Iwen Peter C 
Published: April 2020

Abstract

Objectives
To establish the optimal parameters for group testing of pooled specimens for the detection of SARS-CoV-2.

Methods
The most efficient pool size was determined to be five specimens using a web-based application. From this analysis, 25 experimental pools were created using 50 µL from one SARS-CoV-2 positive nasopharyngeal specimen mixed with 4 negative patient specimens (50 µL each) for a total volume of 250 µL. Viral RNA was subsequently extracted from each pool and tested using the CDC SARS-CoV-2 RT-PCR assay. Positive pools were consequently split into individual specimens and tested by extraction and PCR. This method was also tested on an unselected group of 60 nasopharyngeal specimens grouped into 12 pools.

Results
All 25 pools were positive with cycle threshold (Ct) values within 0 and 5.03 Ct of the original individual specimens. The analysis of 60 specimens determined that 2 pools were positive followed by identification of 2 individual specimens among the 60 tested. This testing was accomplished while using 22 extractions/PCR tests, a savings of 38 reactions.

Conclusions
When the incidence rate of SARS-CoV-2 infection is 10% or less, group testing will result in the saving of reagents and personnel time with an overall increase in testing capability of at least 69%.
Characterization of clinical knowledge and problem-solving assessments employed in postgraduate year 1 pharmacy residency interviews
Authors: Eudaley Sarah T , Mihm Alexandra E , Hammond Drayton A , Szwak Jennifer , Swanson Joseph M 
Published: April 2020

Abstract

Purpose
Attainment of postgraduate year 1 (PGY1) residency positions has become increasingly competitive. Inclusion of clinical knowledge and problem-solving assessments in onsite interviews has increased in recent years. Characterization of these assessments is necessary for applicants to best prepare for interviews and for mentors to provide guidance.

Methods
An online survey was emailed to program directors of PGY1 pharmacy residency programs accredited by the American Society of Health-System Pharmacists (ASHP). Data were analyzed using descriptive statistics. Chi-square and Fisher’s exact tests were used to compare categorical data. The Mann-Whitney U test was used to analyze nonparametric continuous data.

Results
Of the 221 respondents, most identified their programs as based at community (48%) or academic (39%) medical centers. Ninety percent of programs reported inclusion of clinical knowledge and problem-solving assessments in the onsite interview process. The most common assessments included asking clinical questions (70%), development of a SOAP (subjective, objective, assessment, plan) note or care plan (42%), and formal presentations that applicants prepared prior to arrival (39%). Most programs (71%) reported incorporating multiple assessments, with 2 assessments included most commonly (43%). Clinical assessment performance accounted for 10% to 25% of the overall interview score in approximately half of programs.

Conclusion
During onsite PGY1 residency interviews, applicants must be prepared to participate in at least 1 clinical knowledge and problem-solving assessment, including answering clinical questions, developing a SOAP note or care plan, and/or delivering a presentation. Applicants should expect that these assessments will account for a substantial portion of the interview evaluation.
Decolonizing Anglo-American Political Philosophy: The Case of Migration Justice
Authors: Jaggar I—Alison M 
Published: April 2020

AbstractInternational migration is increasing not only in absolute terms but also as a percentage of the global population. In 2019, international migrants made up 3.5 per cent of the global population, compared to 2.8 per cent in the year 2000. Over the past two decades, a philosophical literature has emerged to investigate what justice requires with respect to these vast migrant flows. My article criticizes much of this philosophical work. Building on the work of Charles Mills (2015), I argue that the terms in which many Anglo-American philosophers presently debate migration justice neglect and even obscure consideration of the ways in which current migration flows may be shaped by Euro-American colonialism and neo-colonialism. Such exclusions produce systematic biases in much of our philosophical literature. To develop less biased understandings of migration justice, I propose that Anglo-American philosophers should revise our methods and our conceptual frameworks to enable exploring the possible extent and ethical implications of colonial and neo-colonial influence. This is one part of the much larger task of decolonizing our political philosophy.