bluuebunny/crossref_metadata_2025_split huggingface dataset:
2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias
Authors: Cronin Edmond M. , Bogun Frank M. , Maury Philippe , Peichl Petr , Chen Minglong , Namboodiri Narayanan , Aguinaga Luis , Leite Luiz Roberto , Al-Khatib Sana M. , Anter Elad , Berruezo Antonio , Callans David J. , Chung Mina K. , Cuculich Phillip , d’Avila Andre , Deal Barbara J. , Bella Paolo Della , Deneke Thomas , Dickfeld Timm-Michael , Hadid Claudio , Haqqani Haris M. , Kay G. Neal , Latchamsetty Rakesh , Marchlinski Francis , Miller John M. , Nogami Akihiko , Patel Akash R. , Pathak Rajeev Kumar , Saenz Morales Luis C. , Santangeli Pasquale , Sapp John L. , Sarkozy Andrea , Soejima Kyoko , Stevenson William G. , Tedrow Usha B. , Tzou Wendy S. , Varma Niraj , Zeppenfeld Katja 
Published: January 2020

AbstractVentricular arrhythmias are an important cause of morbidity and mortality and come in a variety of forms, from single premature ventricular complexes to sustained ventricular tachycardia and fibrillation. Rapid developments have taken place over the past decade in our understanding of these arrhythmias and in our ability to diagnose and treat them. The field of catheter ablation has progressed with the development of new methods and tools, and with the publication of large clinical trials. Therefore, global cardiac electrophysiology professional societies undertook to outline recommendations and best practices for these procedures in a document that will update and replace the 2009EHRA/HRS Expert Consensus on Catheter Ablation of Ventricular Arrhythmias. An expert writing group, after reviewing and discussing the literature, including a systematic review and meta-analysis published in conjunction with this document, and drawing on their own experience, drafted and voted on recommendations and summarized current knowledge and practice in the field. Each recommendation is presented in knowledge byte format and is accompanied by supportive text and references. Further sections provide a practical synopsis of the various techniques and of the specific ventricular arrhythmia sites and substrates encountered in the electrophysiology lab. The purpose of this document is to help electrophysiologists around the world to appropriately select patients for catheter ablation, to perform procedures in a safe and efficacious manner, and to provide follow-up and adjunctive care in order to obtain the best possible outcomes for patients with ventricular arrhythmias.
Finite element analysis of Tumor Treating Fields in a patient with posterior fossa glioblastoma
Authors: Lok Edwin , San Pyay , Liang Olivia , White Victoria , Wong Eric T. 
Published: January 2020

Abstract
Introduction
Tumor Treating Fields (TTFields) are alternating electric fields at 200 kHz that disrupt tumor cells as they undergo mitosis. Patient survival benefit has been demonstrated in randomized clinical trials but much of the data are available only for supratentorial glioblastomas. We investigated a series of alternative array configurations for the posterior fossa to determine the electric field coverage of a cerebellar glioblastoma.

Methods
Semi-automated segmentation of neuro-anatomical structures was performed while the gross tumor volume (GTV) was manually delineated. A three-dimensional finite-element mesh was generated and then solved for field distribution.

Results
Compared to the supratentorial array configuration, the alternative array configurations consist of posterior displacement the 2 lateral opposing arrays and inferior displacement of the posteroanterior array, resulting in an average increase of 46.6% electric field coverage of the GTV as measured by the area under the curve of the electric field-volume histogram (EAUC). Hotspots, or regions of interest with the highest 5% of TTFields intensity (E5%), had an average increase of 95.6%. Of the 6 posterior fossa configurations modeled, the PAHorizontal arrangement provided the greatest field coverage at the GTV when the posteroanterior array was placed centrally along the patient’s posterior neck and horizontally parallel, along the longer axis, to the coronal plane of the patient’s head. Varying the arrays also produced hotspots proportional to TTFields coverage.

Conclusions
Our finite element modeling showed that the alternative array configurations offer an improved TTFields coverage to the cerebellar tumor compared to the conventional supratentorial configuration.
A probabilistic projection of beneficiaries of long-term care insurance in Germany by severity of disability
Authors: Vanella Patrizio , Heß Moritz , Wilke Christina B. 
Published: January 2020

AbstractDemographic aging puts social insurance systems under immense pressure as frailty risks increase with age. The statutory long-term care insurance in Germany (GPV), whose society has been aging for decades due to low fertility and decreasing mortality, faces massive future pressure. The present study presents a stochastic outlook on long-term care insurance in Germany until 2045 by forecasting the future number of frail persons who could claim insurance services by severity level with theory-based Monte Carlo simulations. The simulations result in credible intervals for age-, sex- and severity-specific care rates as well as the numbers of persons for all combinations of age, sex and severity by definition of the GPV on an annual basis. The model accounts for demographic trends through time series analysis and considers all realistic epidemiological developments by simulation. The study shows that increases in the general prevalence of disabilities, especially for severe disabilities, caused by the demographic development in Germany are unavoidable, whereas the influence of changes in age-specific care risks does not affect the outcome significantly. The results may serve as a basis for estimating the future demand for care nurses and the financial expenses of the GPV.
Research progress on human infection with avian influenza H7N9
Authors: Wu Xiaoxin , Xiao Lanlan , Li Lanjuan 
Published: January 2020

AbstractSince the first case of novel H7N9 infection was reported, China has experienced five epidemics of H7N9. During the fifth wave, a highly pathogenic H7N9 strain emerged. Meanwhile, the H7N9 virus continues to accumulate mutations, and its affinity for the human respiratory epithelial sialic acid 2–6 receptor has increased. Therefore, a pandemic is still possible. In the past 6 years, we have accumulated rich experience in dealing with H7N9, especially in terms of virus tracing, epidemiological research, key site mutation monitoring, critical disease mechanisms, clinical treatment, and vaccine development. In the research fields above, significant progress has been made to effectively control the spread of the epidemic and reduce the fatality rate. To fully document the research progress concerning H7N9, we reviewed the clinical and epidemiological characteristics of H7N9, the key gene mutations of the virus, and H7N9 vaccine, thus providing a scientific basis for further monitoring and prevention of H7N9 influenza epidemics.
Recent Advances in Immobilization Strategies for Biomolecules in Sensors Using Organic Field-Effect Transistors
Authors: Li Le , Wang Siying , Xiao Yin , Wang Yong 
Published: January 2020

AbstractOrganic field-effect transistors (OFETs) are fabricated using organic semiconductors (OSCs) as the active layer in the form of thin films. Due to its advantages of high sensitivity, low cost, compact integration, flexibility, and printability, OFETs have been used extensively in the sensing area. For analysis platforms, the construction of sensing layers is a key element for their efficient detection capability. The strategy used to immobilize biomolecules in these devices is especially important for ensuring that the sensing functions of the OFET are effective. Generally, analysis platforms are developed by modifying the gate/electrolyte or OSC/electrolyte interface using biomolecules, such as enzymes, antibodies, or deoxyribonucleic acid (DNA) to ensure high selectivity. To provide better or more convenient biological immobilization methods for researchers in this field and thereby improve detection sensitivity, this review summarizes recent developments in the immobilization strategies used for biological macromolecules in OFETs, including cross-linking, physical adsorption, embedding, and chemical covalent binding. The influences of biomolecules on device performance are also discussed.
Maternal mycotoxin exposure and adverse pregnancy outcomes: a systematic review
Authors: Kyei Nicholas N. A. , Boakye Daniel , Gabrysch Sabine 
Published: January 2020

AbstractMycotoxin exposure from food occurs globally but is more common in hot humid environments, especially in low-income settings, and might affect pregnancy outcomes. This study aimed to synthesize the evidence from epidemiological studies on the relationship between maternal or fetal exposure to different mycotoxins and the occurrence of adverse pregnancy outcomes. Multiple databases were systematically searched up to December 2018 to identify studies that assessed the association between mycotoxin exposure in pregnant women or fetuses and at least one pregnancy outcome. Studies were appraised and results were synthesized using standard methods for conducting systematic reviews. This review identified and included 17 relevant studies. There is some evidence to suggest that exposure to various Aspergillus mycotoxins (e.g., aflatoxin) during pregnancy may impair intrauterine fetal growth and promote neonatal jaundice. Findings were inconclusive concerning the influence of aflatoxin exposure on perinatal death and preterm birth. Only two studies assessed effects of maternal exposure to Fusarium mycotoxins (e.g., fumonisin) on adverse pregnancy outcomes. These studies found that maternal fumonisin exposure may be associated with hypertensive emergencies in pregnancy and with neural tube defects. Studies using grain farming and weather conditions as a proxy measure for mycotoxin exposure found that such exposure was associated with an increased risk of preterm birth and late-term miscarriage. In conclusion, there is already some evidence to suggest that exposure to mycotoxins during pregnancy may have detrimental effects on pregnancy outcomes. However, given the limited number of studies, especially on effects of Fusarium mycotoxins, more studies are needed for a more comprehensive understanding of the effects of different mycotoxins on maternal and fetal health and to guide public health policies and interventions.
Stronger Lie derivations on MA-semirings
Authors: Ahmed Yaqoub , Dudek Wieslaw A. 
Published: January 2020

AbstractOn an additively inverse MA-semiring S we consider the additive mapping $$f:S\rightarrow S$$

f
:
S
→
S

satisfying the identity $$f(xy)=[x,f(y)]$$

f
(
x
y
)
=
[
x
,
f
(
y
)
]

, where [a, b] is a commutator of a and b. We investigate the properties of such a mapping and determine the commutativity of S using this mapping.
Experimental analyses of synthetic jet control effects on aerodynamic characteristics of helicopter rotor
Authors: Ma Y.Y. , Zhao Q.J. , Chen X. , Zhao G.Q. 
Published: January 2020

ABSTRACTExperimental analyses of synthetic jet control (SJC) effects on aerodynamic characteristics of rotor in steady state and in hover were conducted. To ensure the structural strength of rotor and enough interior space for holding the synthetic jet actuators (SJAs), a particular blade with a frame-covering structure was designed and processed, and the experiment was conducted with low free stream velocities and rotor rotation speeds. There were three test conditions. In steady state, there were three free stream velocities (10m/s, 15m/s and 20m/s). In hover state, the rotor was worked with two rotation speeds of 180RPM and 240RPM. In forward flight, the rotor was worked with a rotation speed of 180RPM and a free stream velocity of 7.5m/s. To measure the synthetic jet control effect on rotor in stall, the range of collective pitch was set from 10° to 28° in steady state. The aerodynamic forces and sectional velocity field were measured by using the six-component balance and the Particle Image Velocimetry (PIV) system in the wind tunnel. Flow control effects on the blade based on the synthetic jets (SJ) were experimentally investigated with different jet parameters, such as jet locations, jet angles, and jet velocities. In steady state, the jet closer to the leading edge, and the jet angle of 90° had more advantages in improving the aerodynamic characteristics. Furthermore, the aerodynamic forces and sectional velocity field measurement of rotor in hover were conducted, it showed that SJAs could increase flow velocity at the upper surface, which led to lower upper surface pressure. As a result, the normal forces of rotor with two rotation speeds were increased significantly. These results indicated that the synthetic jet has a capability of increasing the normal force and delaying or preventing the stall of rotor.
Coffee and controversy: How applied psychology can revitalize sexual harassment and racial discrimination training
Authors: Hayes Theodore L. , Kaylor Leah E. , Oltman Kathleen A. 
Published: January 2020

AbstractTraining has shown little effectiveness in altering harassing or discriminatory behavior. Limitations of prior intervention efforts may reflect poor conceptualization of the problems involved, poor training intervention design, approaches that engender cynicism, or misunderstanding psychological principles of attitude and behavior change. Interventions should capitalize on behavioral science models and tools at multiple levels from a broad array of disciplines to explain harassment and bias, and then to defeat these behaviors. Measures to ensure fair treatment should focus on leadership socialization, organizational culture and climate, increased professional competence, and integration with organizational approaches to corporate social responsibility and performance.
Quantifying parameter uncertainty in a large-scale glacier evolution model using Bayesian inference: application to High Mountain Asia
Authors: Rounce David R. , Khurana Tushar , Short Margaret B. , Hock Regine , Shean David E. , Brinkerhoff Douglas J. 
Published: January 2020

AbstractThe response of glaciers to climate change has major implications for sea-level change and water resources around the globe. Large-scale glacier evolution models are used to project glacier runoff and mass loss, but are constrained by limited observations, which result in models being over-parameterized. Recent systematic geodetic mass-balance observations provide an opportunity to improve the calibration of glacier evolution models. In this study, we develop a calibration scheme for a glacier evolution model using a Bayesian inverse model and geodetic mass-balance observations, which enable us to quantify model parameter uncertainty. The Bayesian model is applied to each glacier in High Mountain Asia using Markov chain Monte Carlo methods. After 10,000 steps, the chains generate a sufficient number of independent samples to estimate the properties of the model parameters from the joint posterior distribution. Their spatial distribution shows a clear orographic effect indicating the resolution of climate data is too coarse to resolve temperature and precipitation at high altitudes. Given the glacier evolution model is over-parameterized, particular attention is given to identifiability and the need for future work to integrate additional observations in order to better constrain the plausible sets of model parameters.
Drivers of hunting in the savannahs of Amapá: implications for conservation
Authors: Silvestre Saulo M. , Calle-Rendón Bayron R. , de Toledo José J. , Hilário Renato R. 
Published: January 2020

AbstractAlthough overhunting is amongst the main threats to biodiversity, wild meat is culturally and nutritionally important for many communities. Conservation initiatives should therefore address the drivers of hunting, rather than its practice alone. Here we gathered information from structured interviews with 68 local households to assess the drivers of hunting in a highly threatened Amazonian savannah complex, the Cerrado of Amapá in Brazil. We used regression models to evaluate the influence of socio-economic parameters and spatial variables on hunting prevalence and frequency. The only identified driver of hunting prevalence was forest cover, whereas five variables had significant effects on hunting frequency. The positive effect of forest cover and the negative effect of hunter's age on hunting frequency suggest that logistical and physical feasibility are important drivers of hunting frequency. Furthermore, we suggest that the negative effect of distance to urban centres may be related to the profitability of hunting. We base this on the negative effect of river length in the vicinity of households and per capita monthly income on hunting frequency, which corroborates the tendency of hunting frequency to decrease when alternatives to wild meat are more readily available. We argue that to reduce unsustainable hunting it is necessary both to raise awareness amongst local communities and involve them in the creation of management plans that conserve biodiversity and meet economic and social needs.
Each/Every: CADA's Radically Democratic Dramaturgy of Dissent
Authors: Thompson Jennifer Joan 
Published: January 2020

We are therefore saying that the work of expanding the habitual levels of life is the only valid art installation / the only exhibition / the only work of art that lives.We are artists and we feel ourselves participating in the grand aspirations of all, presuming today, with South American love, the gliding of eyes over these lines.Oh, South America.In this way, together, we construct the beginning of the work: a recognition in our minds; erasing the trades: life as a creative act …That is the art / the work / this is the work of art that we propose.—¡Ay Sudamérica!,Colectivo Acciones de Arte, July 1981At 11a.m.on 11 September 1973, the Chilean Air Force bombed the presidential palace, La Moneda, as part of an attack that ended the presidency of Salvador Allende, suspended democracy, and initiated the repressive military dictatorship of Augusto Pinochet. Eight years later, on 12 July 1981, in the midst of dictatorship, six airplanes again flew over Santiago in military formation. This time, however, the planes did not drop bombs. Instead, they scattered four hundred thousand pamphlets with a text that urged Chileans to claim their space, thoughts, and lives by asserting the potential for artistry within all people. This art action, titled¡Ay Sudamérica!(Oh, South America!) and orchestrated by the Colectivo Acciones de Arte (Art Actions Collective, or CADA), subversively re-created a central moment from the violent history of the military coup in order to disturb and articulate an alternative course for that history (Fig. 1). In doing so, CADA challenged the regime's conception of Chilean citizenship by calling for an expanded space of existence and invoking the possibility of an artistic and contestatory subjectivity within everyone.
Effects of obesity on cholesterol metabolism and its implications for healthy ageing
Authors: Mc Auley Mark Tomás 
Published: January 2020

AbstractThe last few decades have witnessed a global rise in the number of older individuals. Despite this demographic shift, morbidity within this population group is high. Many factors influence healthspan; however, an obesity pandemic is emerging as a significant determinant of older people’s health. It is well established that obesity adversely affects several metabolic systems. However, due to its close association with overall cardiometabolic health, the impact that obesity has on cholesterol metabolism needs to be recognised. The aim of the present review is to critically discuss the effects that obesity has on cholesterol metabolism and to reveal its significance for healthy ageing.
Everolimus for cardiac rhabdomyomas in children with tuberous sclerosis. The ORACLE study protocol (everOlimus for caRdiac rhAbdomyomas in tuberous sCLErosis): a randomised, multicentre, placebo-controlled, double-blind phase II trial
Authors: Stelmaszewski Erica V. , Parente Daniella B. , Farina Alberto , Stein Anna , Gutierrez Anthony , Raquelo-Menegassio Antonio F. , Manterola Carla , de Sousa Carolina F. , Victor Carolina , Maki Dina , Morón Elias M. , de Abrantes Fabiano F. , Iqbal Fatima , Camacho-Vilchez Jazmin , Jimenez-Pavón Joanna , Polania Juan P. , Thompson Lorenzo , Bonanato Lygia , Diebold Matthias , Da Silva Maria V. C. P. , Nashwan Mariam W. J. , Galvani Marianna A. G. , Idris Osama E. A. , Danos Pierina , Ortiz-Lopez Rocio , Mahmoud Rofida A. A. , Gresse Sergio , Loss Karla L. 
Published: January 2020

AbstractIntroduction:Tuberous sclerosis complex is a rare genetic disorder leading to the growth of hamartomas in multiple organs, including cardiac rhabdomyomas. Children with symptomatic cardiac rhabdomyoma require frequent admissions to intensive care units, have major complications, namely, arrhythmias, cardiac outflow tract obstruction and heart failure, affecting the quality of life and taking on high healthcare cost. Currently, there is no standard pharmacological treatment for this condition, and the management includes a conservative approach and supportive care. Everolimus has shown positive effects on subependymal giant cell astrocytomas, renal angiomyolipoma and refractory seizures associated with tuberous sclerosis complex. However, evidence supporting efficacy in symptomatic cardiac rhabdomyoma is limited to case reports. The ORACLE trial is the first randomised clinical trial assessing the efficacy of everolimus as a specific therapy for symptomatic cardiac rhabdomyoma.Methods:ORACLE is a phase II, prospective, randomised, placebo-controlled, double-blind, multicentre protocol trial. A total of 40 children with symptomatic cardiac rhabdomyoma secondary to tuberous sclerosis complex will be randomised to receive oral everolimus or placebo for 3 months. The primary outcome is 50% or more reduction in the tumour size related to baseline. As secondary outcomes we include the presence of arrhythmias, pericardial effusion, intracardiac obstruction, adverse events, progression of tumour reduction and effect on heart failure.Conclusions:ORACLE protocol addresses a relevant unmet need in children with tuberous sclerosis complex and cardiac rhabdomyoma. The results of the trial will potentially support the first evidence-based therapy for this condition.
Ductal arterial spasm: a nightmare
Authors: Phyu Hnin L. , Oo Khin M. 
Published: January 2020

AbstractDuctal arterial spasm is a very potentially dangerous incidence during percutaneous device closure of patent ductus arteriosus (PDA), which, otherwise, is a very safe catheter intervention. It is essential to notice its occurrence before device sizing and deploying. Without awareness, it can mislead device selection and can result in serious complication. In this report, we shared our nightmare of ductal spasm during transcatheter closure of PDA in two children which had led to death in one patient.