bluuebunny/crossref_metadata_2025_split huggingface dataset:
Innovative Polymers for Next‐Generation Batteries
Authors: Mecerreyes David , Porcarelli Luca , Casado Nerea 
Published: January 2020

AbstractLithium‐ion batteries are part of modern life, being present in daily‐used objects such as mobile phones, tablets, computers, watches, sport accessories, electric scooters, and cars. The next‐generation batteries require the development of innovative polymers that help to improve their performance in terms of power density, cyclability, raw materials' availability, low weight, printability, flexibility, sustainability, or security. This article highlights recent developments in the area of redox‐active, electronic/ionic conducting polymers. This includes the development of innovative binders for electrodes, polymer electrolytes, and redox polymers. All these new polymer developments are leading to new battery technologies such as metal–polymer batteries, organic batteries, polymer–air, and redox–flow batteries, which are expected to complement the current lithium‐ion technologies in the future.
Self‐Healing Metallo‐Supramolecular Hydrogel Based on Specific Ni2+ Coordination Interactions of Poly(ethylene glycol) with Bistriazole Pyridine Ligands in the Main Chain
Authors: Xu Xiaowen , Jerca Valentin Victor , Hoogenboom Richard 
Published: January 2020

AbstractIn this study, a supramolecular hydrogel formed by incorporating the 2,6‐bis(1,2,3‐triazol‐4‐yl)‐pyridine (btp) ligand in the backbone of a polymer prepared by copper(I)‐catalyzed alkyne‐azide cycloaddition (CuAAC) “click” polyaddition reaction of 2,6‐diethynylpyridine and diazido‐poly(ethylene glycol) is reported. The hydrogelation is selectively triggered by the addition of Ni2+ ions to aqueous copolymer solutions. The gelation and rheological properties could be tuned by the change of metal to ligand ratio and polymer concentration. Interestingly, the hydrogel exhibits a fast (within 2 min) and excellent repeatable autonomic healing capacity without external stimuli. This self‐healing behavior may find potential applications for the repairing of metal coatings, in the future.
Extending the spectrum of CLRN1‐ and ABCA4‐associated inherited retinal dystrophies caused by novel and recurrent variants using exome sequencing
Authors: Abu‐Ameerh Mohammed , Mohammad Hashim , Dardas Zain , Barham Raghda , Ali Dema , Bijawi Maysa , Tawalbeh Mohamed , Amr Sami , Hatmal Ma'mon M. , Al‐Bdour Muawyah , Awidi Abdalla , Azab Belal 
Published: January 2020

AbstractBackgroundInherited retinal dystrophies (IRDs) are characterized by extreme genetic and clinical heterogeneity. There are many genes that are known to cause IRD which makes the identification of the underlying genetic causes quite challenging. And in view of the emergence of therapeutic options, it is essential to combine molecular and clinical data to correctly diagnose IRD patients. In this study, we aimed to identify the disease‐causing variants (DCVs) in four consanguineous Jordanian families with IRDs and describe genotype–phenotype correlations.MethodsExome sequencing (ES) was employed on the proband patients of each family, followed by segregation analysis of candidate variants in affected and unaffected family members by Sanger sequencing. Simulation analysis was done on one novel CLRN1 variant to characterize its effect on mRNA processing. Clinical evaluation included history, slit‐lamp biomicroscopy, and indirect ophthalmoscopy.ResultsWe identified two novel variants in CLRN1 [(c.433+1G>A) and (c.323T>C, p.Leu108Pro)], and two recurrent variants in ABCA4 [(c.1648G>A, p.Gly550Arg) and (c.5460+1G>A)]. Two families with the same DCV were found to have different phenotypes and another family was shown to have sector RP. Moreover, simulation analysis for the CLRN1 splice donor variant (c.433+1G>A) showed that the variant might affect mRNA processing resulting in the formation of an abnormal receptor. Also, a family that was previously diagnosed with nonsyndromic RP was found to have Usher syndrome based on their genetic assessment and audiometry.ConclusionOur findings extend the spectrum of CLRN1‐ and ABCA4‐associated IRDs and describe new phenotypes for these genes. We also highlighted the importance of combining molecular and clinical data to correctly diagnose IRDs and the utility of simulation analysis to predict the effect of splice donor variants on protein formation and function.
3D isocentricity analysis for clinical linear accelerators
Authors: Velten Christian , Wang Yi‐Fang , Adamovics John , Wuu Cheng‐Shie 
Published: January 2020

PurposeTo perform a three‐dimensional (3D) concurrent isocentricity measurement of a clinical linear accelerator’s (linac) using a single 3D dosimeter, PRESAGE.MethodsA 3D dosimeter, PRESAGE, set up on the treatment couch of a Varian TrueBeam LINAC using the setup lasers, was irradiated under gantry angles of 0, 50, 160, and 270 with the couch fixed at 0 and subsequently, under couch angles of 10, 330, 300, and 265 with the gantry fixed at 270. The 1 cm (at 100 cm SAD) square fields were delivered at 6 MV with 800 MU/field. After irradiation, the dosimeter was scanned using a single‐beam optical scanner and images were reconstructed with submillimeter resolution using filtered back‐projection. Postprocessing was used to extract views parallel to the star‐shot planes from which beam trajectories and the smallest circles enclosing these were drawn and extracted. These circles and information from the view orthogonal to both star‐shots were used to represent the rotational centers as spheroids. The linac isocenter was defined by the distribution of midpoints between any, randomly selected, points lying inside the center spheroids defined by the table and gantry rotations; isocenter location and size were defined by the average midpoint and the distribution’s semi‐axes. Collimator rotations were not included in this study.ResultsRelative to the setup center defined by lasers, the table and gantry rotation center coordinates (lat., long., vert.) were measured in units of millimeters, to be (−0.24, 0.18, −0.52) and (0.10, 0.53, −0.52), respectively. Displacements from the setup center were 0.60 and 0.75 mm for the table and gantry centers, while the distance between them measured 0.49 mm. The linac’s radiation isocenter was calculated to be at (−0.07, −0.17, 0.51) relative to the setup lasers and its size was found to be most easily described by a spheroid prolate in vertical direction with semi‐axis lengths of 0.13 and 0.23 mm for the lateral‐longitudinal and vertical directions, respectively.ConclusionsThis study demonstrates how to measure the location and sizes of rotational centers in 3D with one setup. The proposed method provides a more comprehensive view on the isocentricity of LINAC than the conventional two‐dimensional film measurements. Additionally, a new definition of isocenter and its size was proposed.
Evaluation of RF interactions between a 3T birdcage transmit coil and transcranial magnetic stimulation coils using a realistically shaped head phantom
Authors: Navarro de Lara Lucia I. , Golestanirad Laleh , Makarov Sergey N. , Stockmann Jason P. , Wald Lawrence L. , Nummenmaa Aapo 
Published: January 2020

PurposeMultichannel transcranial magnetic stimulation (TMS)1 is an emerging technology that allows multiple sites to be stimulated simultaneously or sequentially under electronic control without movement of the coils. A multichannel TMS/MRI head coil array for 3 Tesla is currently under development to mitigate challenges of concurrent TMS/fMRI as well as enable potential new applications. The influence of the multichannel TMS system on the MR image quality and safety must be carefully investigated.MethodsA standard birdcage volume coil for 3 Tesla systems was simulated using a commercial numerical electromagnetic solver. Two setups, consisting of 1) a MR‐compatible TMS coil, and 2) a 3‐axis TMS coil array, were simulated to quantify changes in the transmit field and the SAR. A realistically shaped homogeneous head model was used in the computations.ResultsThe stimulation coils produced enhancements and attenuations on the transmit field with effects greater than 5% up to 2.4 cm and 3.3 cm under the scalp for the MR‐compatible TMS coil and 3‐axis TMS coil array, respectively. The 10 g‐SAR distribution did not change significantly in either of the cases; however, the nominal SAR maximum locus was shifted between existing hot spots.ConclusionThe simulated variations found near the TMS coils indicate the possibility of inducing sequence‐dependent image artefacts predominatly limited to the vicinity of the coil(s). However, we conclude that neither the MR‐compatible commercial TMS coil nor the 3‐axis TMS coil array siginificantly elevate SAR in the head or neck beyond accepted safety limits.
Evaluation of lower urinary tract symptoms in children with Down syndrome: A prospective, case‐controlled cohort study
Authors: Kızılay Fuat , İrer Bora , Özalp Kızılay Deniz , Şimşir Adnan , Kalemci Serdar , Şen Volkan , Altay Barış , Çoğulu Özgür 
Published: January 2020

AbstractAimsIn children with Down syndrome (DS) which causes cognitive impairment and intellectual disability (ID), dysfunctional voiding is proposed to be more common than in the normal population. In this study, we aimed to compare the voiding symptoms of DS children with a control group by validated questionnaires.MethodsThirty‐seven DS children without any previous urological complaints and 59 non‐DS healthy children as control group was included in the study. Overactive bladder symptoms and dysfunctional voiding were evaluated with validated Overactive Bladder Questionnaire (OAB‐V8) and Dysfunctional Voiding Symptom Score (DVSS) questionnaire, respectively. Data were arranged, descriptive and comparative statistical analysis were performed.ResultsDemographic data of the two groups were similar except age of completing toilet training being higher in DS group. Total OAB‐V8 and DVSS scores were significantly higher in the DS group. The mean scores of questions regarding voiding frequency, urgency and urgency incontinence in OAB‐V8 were significantly higher in the DS group. The mean daytime incontinence, urgency, urgency incontinence, and quality of life scores in the DVSS were also significantly higher in the DS group.ConclusionsDS children have more frequent dysfunctional voiding than the normal population. ID of these children may prevent the expression of these symptoms. Awareness and early detection of these symptoms are crucial to prevent devastating complications such as renal failure. Therefore, validated questionnaires are simple, useful, and noninvasive methods.
An asymptotic preserving scheme on staggered grids for the barotropic Euler system in low Mach regimes
Authors: Goudon Thierry , Llobell Julie , Minjeaud Sebastian 
Published: January 2020

AbstractWe present a new scheme for the simulation of the barotropic Euler equation in low Mach regimes. The method uses two main ingredients. First, the system is treated with a suitable time splitting strategy, directly inspired from the previous study that separates low and fast waves. Second, we adapt a numerical scheme where the discrete densities and velocities are stored on staggered grids, in the spirit of MAC methods, and with numerical fluxes derived from the kinetic approach. We bring out the main properties of the scheme in terms of consistency, stability, and asymptotic behavior, and we present a series of numerical experiments to validate the method.
Association Between Life‐Course Obesity and Frailty in Older Adults: Findings in the GAZEL Cohort
Authors: Landré Benjamin , Czernichow Sébastien , Goldberg Marcel , Zins Marie , Ankri Joël , Herr Marie 
Published: January 2020

ObjectiveThis study aimed to assess the relationship between weight history during adulthood and frailty in late life in men and women participating in the GAZEL (GAZ and ELectricité) cohort.MethodsThis cohort study included 8,751 men and 3,033 women (aged 61 to 76 years) followed up since 1989. Modified Fried’s frailty criteria (weakness, fatigue, unintentional weight loss, low physical activity, and impaired mobility) were assessed in 2015. Reported BMI was determined each year to characterize: obesity status in 2015, obesity duration over the 1990 to 2015 period, and trajectories of BMI. Associations between frailty and weight history were assessed using multinomial regression.ResultsIn 2015, 12% of men had obesity, 1.8% severe obesity, and 0.4% morbid obesity; for women, these percentages were 11%, 2.2%, and 0.8%, respectively. Individuals with obesity were more likely to be frail than those with normal BMI and the risk of frailty increased with each additional year of obesity (adjusted odds ratio 1.04 [1.00–1.08] for men and 1.07 [1.02–1.13] for women). Trajectories of BMI revealed that both long‐term obesity and onset of obesity in late adulthood were associated with frailty.ConclusionsCurrent and past obesity appear to be important determinants of frailty. Early weight management may be beneficial in old age.
Behavioral and Psychological Strategies of Long‐Term Weight Loss Maintainers in a Widely Available Weight Management Program
Authors: Phelan Suzanne , Halfman Tate , Pinto Angela Marinilli , Foster Gary D. 
Published: January 2020

ObjectiveThe study’s purpose was to use validated questionnaires to identify novel behavioral and psychological strategies among weight loss maintainers (WLMs) in a commercial weight management program.MethodsParticipants were 4,786 WLMs in WW (formerly Weight Watchers, New York, New York) who had maintained weight loss  ≥ 9.1 kg (24.7 kg/23.8% weight loss on average) for 3.3 years and had a current mean BMI of 27.6 kg/m2. A control group of 528 weight‐stable individuals with obesity had a mean BMI of 38.9 kg/m2 and weight change  < 2.3 kg over the previous 5 years.ResultsWLMs versus Controls practiced more frequent healthy dietary choices (3.3 vs. 1.9;  = 0.37), self‐monitoring (2.6 vs. 0.7;  = 0.30), and psychological coping (2.5 vs. 1.1;  = 0.25) strategies. WLMs also reported more willingness to ignore food cravings (4.4 vs. 3.5;  = 0.16) and had greater habit strength for healthy eating (5.3 vs. 3.2;  = 0.21). Standard canonical coefficients indicated that dietary (0.52), self‐monitoring (0.40), and psychological (0.14) strategies as well as habit strength for healthy eating (0.15) contributed independently and most (49.5% of variance) to discriminating groups.ConclusionsIn a widely available weight management program, more frequent practice of healthy dietary, self‐monitoring, and psychological coping strategies as well as development of greater habit strength for healthy eating differentiated long‐term WLMs from weight‐stable individuals with obesity.
Early Infant Feeding and BMI Trajectories in the First 5 Years of Life
Authors: Zheng Miaobing , Cameron Adrian J. , Birken Catherine S. , Keown‐Stoneman Charles , Laws Rachel , Wen Li Ming , Campbell Karen J. 
Published: January 2020

ObjectiveThis study examined the relative impact of breastfeeding duration and timing of solids introduction on BMI z score (BMIz) trajectory in early childhood.MethodsThis study conducted secondary analyses of data from the Melbourne Infant Feeding, Activity and Nutrition Trial (InFANT) Program (N = 542), a prospective cohort study with data collected at birth and 3, 9, 18, 42, and 60 months. Linear spline multilevel models were performed.ResultsDifferential growth rates were observed from birth to 3 months and from 9 to 18 months by breastfeeding duration (≥ 6 vs. < 6 months) and timing of solids introduction (before vs. after 6 months). Children who were breastfed for ≥ 6 versus < 6 months had lower BMIz at all ages from 3 to 60 months. The difference remained after adjusting for child and maternal factors, and the adjusted mean differences in BMIz at 3, 9, 18, 42, and 60 months were −0.34, −0.44, −0.13, −0.19, and −0.23, respectively. Children who received solids before versus after 6 months of age had higher BMIz at 18 and 42 months, but adjustment for child and maternal factors attenuated these differences.ConclusionsLonger breastfeeding duration was associated with lower BMIz to 5 years of age, providing further support for infant feeding guidelines to prolong breastfeeding duration for healthy growth.
Association of Hot Tea Consumption with Regional Adiposity Measured by Dual‐Energy X‐Ray Absorptiometry in NHANES 2003‐2006
Authors: Roberts Justin , Liu Qinran , Cao Chao , Jackson Sarah E. , Zong Xiaoyu , Meyer Gretchen A. , Yang Lin , Cade W. Todd , Zheng Xiaobin , López‐Sánchez Guillermo F. , Wu Xiaojian , Smith Lee 
Published: January 2020

ObjectiveThis study aimed to investigate the potential antiobesity benefits of hot tea consumption at the population level.MethodsUsing data from the National Health and Nutrition Examination Survey (NHANES) 2003‐2006, the association between hot tea consumption and dual‐energy x‐ray–measured body fat was examined in a large representative sample of US adults (n = 5,681, 51.9% women).ResultsCompared with non–tea drinkers, men who consumed 0.25 to 1 cup per day of hot tea had 1.5% (95% CI: 0.4% to 2.6%) and 1.7% (95% CI: 0.4% to 3.0%) less total and trunk body fat, respectively. The associations were stronger among men 45 to 69 years old compared with younger men (20‐44 years). For men who consumed 1 or more cups per day of hot tea, lower total (−1.2%, 95% CI: −2.3% to −0.2%) and trunk body fat (−1.3%, 95% CI: −2.6 to −0.1%) was observed among men 45 to 69 years old only. In women, those who drank 1 or more cups per day had 1.5% lower (95% CI: −2.7% to −0.3%) trunk body fat compared with non–tea drinkers.ConclusionsConsumption of hot tea might be considered as part of a healthy diet in order to support parameters associated with metabolic health and may be particularly important in older male age groups in supporting reduced central adiposity.
Longitudinal Study of Maternal BMI in Successive Pregnancies
Authors: Reynolds Ciara M. E. , Egan Brendan , O’Malley Eimer G. , McMahon Léan , Sheehan Sharon R. , Turner Michael J. 
Published: January 2020

ObjectiveThis longitudinal observational study examined BMI changes between successive pregnancies.MethodsThe computerized medical records of women who attended a large maternity hospital between 2009 and 2017 for their first and second singleton deliveries were analyzed. Women who had their weight first measured after 15 weeks of gestation in either pregnancy were excluded.ResultsOf the 9,724 women, the incidence of obesity increased from 11.6% in the first pregnancy to 16.0% in the second. The mean interpregnancy interval was 32.5 ± 15.7 months, and median BMI change was +0.6 kg/m2 (interquartile range 2.2; P < 0.001). Overall, 10.3% (1,006/9,724) developed overweight and 5.9% (571/9,724) developed obesity by the second pregnancy. Of the nulliparas in the overweight category, 20.6% (526/2,558) entered the obesity category. The development of obesity by the second pregnancy was independently associated with a longer interpregnancy interval, formula feeding at hospital discharge, taking antidepressants or anxiolytics, and postnatal depression. Professional/managerial employment was associated with a lower odds ratio of developing obesity.ConclusionsMaternal obesity increased between the first and second pregnancy, with one‐fifth of nulliparas in the overweight category developing obesity. Pregnancy‐related factors were identified as predictors of developing obesity. Further research is needed to assess whether interventions targeting these related factors could optimize maternal weight management between pregnancies.
Moderating role of social support in the relationship between posttraumatic stress disorder and antisocial behavior in adolescents after the Ya'an earthquake
Authors: Wang Wenchao , Wu Xinchun , Liu Aiyi , Lan Xiaoyu 
Published: January 2020

AbstractThis study explored whether social support moderated the relationship between various symptoms of posttraumatic stress disorder (PTSD) and antisocial behavior. Participants were 597 adolescents from two middle schools in Lushan county, China, an area severely affected by the Ya'an earthquake. All four symptom clusters of PTSD significantly and positively correlated with antisocial behavior. Of the PTSD symptoms, only social support played a significant moderating role in the effects of intrusion and avoidance symptoms on antisocial behavior. Intrusion and avoidance symptoms were associated with more antisocial behavior for individuals with lower social support.
CTCF‐induced upregulation of HOXA11‐AS facilitates cell proliferation and migration by targeting miR‐518b/ACTN4 axis in prostate cancer
Authors: Xing Zengshu , Li Sailian , Liu Zhenxiang , Zhang Chong , Bai Zhiming 
Published: January 2020

AbstractBackgroundTestified as crucial participators in different types of human malignancies, long noncoding RNAs (lncRNAs) have been revealed to exert a significant effect on the complicated courses of tumor progression. Although existing literatures have revealed the oncogenic role of lncRNA homeobox A11 antisense RNA (HOXA11‐AS) in multiple cancers, the underlying role of HOXA11‐AS in prostate cancer (PCa) and its potential molecular mechanism remains poorly understood.AimTo decipher the molecular performance of HOXA11‐AS in PCa.MethodsThe expression of HOXA11‐AS, miR‐518b and actinin alpha 4 (ACTN4) was detected by a real‐time quantitative polymerase chain reaction. Colony formation, EdU, flow cytometry, wound healing, and transwell assays were utilized to explore the biological role of HOXA11‐AS in PCa. The interaction between RNAs (CCCTC‐binding factor [CTCF], HOXA11‐AS, miR‐518b, and ACTN4) was tested via chromatin immunoprecipitation, luciferase reporter and RNA immunoprecipitation assays.ResultsHOXA11‐AS in PCa cells was expressed at high levels. Silenced HOXA11‐AS in PCa cells could lead to a significant elevation in the abilities of cell proliferation and migration whereas a remarkable declination in cell apoptosis capability. Subsequent molecular mechanism assays confirmed that HOXA11‐AS bound with miR‐518b and negatively regulates miR‐518b expression. Besides, HOXA11‐AS could regulate the expression of ACTN4 by sponging miR‐518b. Moreover, rescued‐function assays revealed that miR‐518b inhibition or ACTN4 upregulation reversed the repressive effect of HOXA11‐AS knockdown on PCa progression. Furthermore, CTCF was validated to activate HOXA11‐AS transcription in PCa cells.ConclusionsCTCF‐induced upregulation of HOXA11‐AS facilitates PCa progression via miR‐518b/ACTN4 axis, providing a new target for PCa treatment.
Study on the normalized Laplacian of a penta‐graphene with applications
Authors: Li Qishun , Zaman Shahid , Sun Wanting , Alam Jawad 
Published: January 2020

AbstractLet L
n denote a linear pentagonal chain with 2n pentagons. The penta‐graphene (penta‐C), denoted by R
n is the graph obtained from L
n by identifying the opposite lateral edges in an ordered way, whereas the pentagonal Möbius ring is the graph obtained from the L
n by identifying the opposite lateral edges in a reversed way. In this paper, through the decomposition theorem of the normalized Laplacian characteristic polynomial and the relationship between its roots and the coefficients, an explicit closed‐form formula of the multiplicative degree‐Kirchhoff index (resp. Kemeny's constant, the number of spanning trees) of R
n is obtained. Furthermore, it is interesting to see that the multiplicative degree‐Kirchhoff index of R
n is approximately of its Gutman index. Based on our obtained results, all the corresponding results are obtained for .