bluuebunny/crossref_metadata_2025_split huggingface dataset:
IMPLEMENTATION OF OPTIMUM ADDITIVE TECHNOLOGIES DESIGN FOR UNMANNED AERIAL VEHICLE TAKE-OFF WEIGHT INCREASE
Authors: Maricic Sven , Haber Iva Mrsa , Veljovic Ivan , Palunko Ivana 
Published: November 2020

The aim of this paper is to investigate the possibility of drone optimization by selecting and testing the best material suitable for additive manufacturing technology and generative design approach, i. e. shape optimization. The use of additive manufacturing technology enables the creation of models of more complex shapes that are difficult or impossible to produce with conventional processing methods. The complex and unconventional design of the drone body can open up many possibilities for weight reduction while maintaining the strength of the drone body. By using 3D printing in addition to FEM (Finite Element Method) analysis, and generative design it can identify areas of the drone body that are overdrawn, allowing it to either lift off material or simply change the design at these areas. Choosing the right material for this application is crucial in order to optimise the mechanical properties of the material with weight, material cost, printability and availability of the material and the 3D printing method, while at the same time reducing environmental pollution. The goal is to reduce the drone mass by 15–20 % using generative design tools. Mass is an important segment when prototyping a drone. If the drone is too heavy, more lift power is needed to keep the drone in the air, so the propellers have to turn faster and use more energy. Consequently, the reduction of drone mass should increase the take-off weight. In this article 5 commercial drones of similar characteristics are compared with the final proposal of our 3D printed drone (Prototype 1). The rotor distance between the drones, the weight of the electric motor and the take-off weight are compared. The goal was to produce a prototype with a big rotor distance-to-weight ratio, and take-off weight bigger than observed drones have.
The defined goal function was optimized in order to evaluate characteristics of 12 different 3D printed materials. Following properties: ultimate strength, stiffness, durability, printability of the material, and required bed and extruder temperature for printing were taken in consideration to select optimal material. Polycarbonate proved to be the best choice for 3D printing UAVs
VALIDATION OF THE SPECTROPHOTOMETRIC PROCEDURE FOR DESLORATADINE ASSAY IN TABLETS APPLYING THE UNCERTAINTY CONCEPT OF THE STATE PHARMACOPOEIA OF UKRAINE
Authors: Leontiev Dmytro , Petrus Vasyl , Volovyk Natalia , Gryzodub Oleksandr 
Published: November 2020

Aim. This work aimed to validate an assay procedure for desloratadine tablets by direct spectrophotometric method. Materials and methods. A pilot-scale batch of the pharmaceutical preparation Alerdez, film-coated tablets containing 5 mg of desloratadine, manufactured by PJSC SIC “Borshchahivskiy CPP”, Ukraine, was used as an object of the study. A UV-Vis spectrophotometer Lambda 25 (Perkin Elmer), analytical balance Mettler Toledo XP 205DR, and class A volumetric apparatus were used in the study. Validation of the procedure was performed following the metrological approach of the State Pharmacopoeia of Ukraine (SPhU), whose requirements for the target uncertainty and bias, which rest on the risk assessment of making incorrect decisions on compliance (a confidence level of 95 %), were translated into criteria for all validation characteristics recommended by ICH. All calculations were made in normalised coordinates. The linearity, accuracy and precision (repeatability) were studied in a single experiment using nine different concentrations that uniformly covered the range of ±30 % from the nominal concentration of desloratadine. For validation of the procedure, an SPhU reference standard of desloratadine was used. Results. The experiment design and validation characteristics being tested were in full compliance with ICH Q2(R1) recommendations. All performance characteristics conformed to the criteria recommended by the SPhU. Requirements for the target uncertainty (1.6 %) and bias for any systematic source of variation (≤0.51 %, negligible in relation to 1.6 %) were established. The analytical procedure was specific – the absorbance from the placebo solution was insignificant (A %=0.36). The procedure met the requirements for linearity, accuracy, and precision at the repeatability level. The residual standard deviation s0 was 0.34 (≤ 0.84); correlation index Rc was 0.9998 (≥0.9991); intercept а was 0.045 (less than its confidence interval ∆a=1.14). The confidence interval for recovery ∆Z, which was used as a precision estimate, was 0.55 % (less than the target uncertainty). The mean recovery, which was used as an accuracy estimate, statistically insignificantly deviated from 100% (|Zmean ‑ 100| = 0.022 %). The confidence interval for the intermediate precision ∆intra was 0.33 % (less than the target uncertainty). The developed analytical procedure was found to be robust. Conclusions. A spectrophotometric procedure suitable for the assay of desloratadine in film-coated tablets Alerdez with content limits of ±5 % was validated by the SPhU approach.
Articulação ensino e extensão universitária frente a pandemia de covid-19
Authors: Neves Pessoa João Pedro , Dias cordeiro Maria Luisa , Sande Souza Karla , Coelho Ferreira Vitória Solange , Dantas Santiago dos Anjos Soraya 
Published: November 2020

Este artigo tem o objetivo de abordar as atividades extracurriculares elaboradas no período de isolamento social na pandemia de CoVid-19, pelos discentes e docentes do curso de Enfermagem da Universidade Estadual de Santa Cruz – UESC. Trata-se de um relato de experiência de ação extensionista de abordagem descritiva. Teve como público-alvo 42 municípios do sul da Bahia. As ações foram iniciadas em marco de 2020 e estão ocorrendo de modo contínuo. Foram utilizadas as redes sociais para a divulgação das produções e comunicação com os municípios, sendo realizadas capacitações acerca do uso correto de EPIs e reuniões com os gerentes municipais para discussão de fluxos de atendimento na rede básica. O processo de articulação da extensão de forma remota traz um entendimento sobre a pluralidade de formas de produção de conhecimento do meio acadêmico para a sociedade.
Palavras chaves: Relações Comunidade-Instituição; Infecções por Coronavírus; Consulta Remota.
Podstawy fenomenologii poznania a problem języka. Uwagi do książki Witolda Płotki "Studia z fenomenologii poznania"
Authors: Piekarski Michał 
Published: November 2020

Celem niniejszego artykułu jest dyskusja z niektórymi tezami zawartymi w książce Witolda Płotki, Studia z fenomenologii poznania. Transcedentalna filozofia Edmunda Husserla a problem wiedzy. Zostaje podjęta kwestia dotyczącą miejsca i znaczenia rozważań nad językiem w kontekście fenomenologii Husserlowskiej. Autor zastanawia się, czy język jest medium przezroczystym, czy jednak jest on elementem konstytutywnym dla treści i charakteru doświadczenia.
Artificial Intelligence Techniques That May Be Applied to Primary Care Data to Facilitate Earlier Diagnosis of Cancer: Systematic Review
Authors: Jones Owain T , Calanzani Natalia , Saji Smiji , Duffy Stephen W , Emery Jon , Hamilton Willie , Singh Hardeep , de Wit Niek J , Walter Fiona M 
Published: November 2020

Background
More than 17 million people worldwide, including 360,000 people in the United Kingdom, were diagnosed with cancer in 2018. Cancer prognosis and disease burden are highly dependent on the disease stage at diagnosis. Most people diagnosed with cancer first present in primary care settings, where improved assessment of the (often vague) presenting symptoms of cancer could lead to earlier detection and improved outcomes for patients. There is accumulating evidence that artificial intelligence (AI) can assist clinicians in making better clinical decisions in some areas of health care.

Objective
This study aimed to systematically review AI techniques that may facilitate earlier diagnosis of cancer and could be applied to primary care electronic health record (EHR) data. The quality of the evidence, the phase of development the AI techniques have reached, the gaps that exist in the evidence, and the potential for use in primary care were evaluated.

Methods
We searched MEDLINE, Embase, SCOPUS, and Web of Science databases from January 01, 2000, to June 11, 2019, and included all studies providing evidence for the accuracy or effectiveness of applying AI techniques for the early detection of cancer, which may be applicable to primary care EHRs. We included all study designs in all settings and languages. These searches were extended through a scoping review of AI-based commercial technologies. The main outcomes assessed were measures of diagnostic accuracy for cancer.

Results
We identified 10,456 studies; 16 studies met the inclusion criteria, representing the data of 3,862,910 patients. A total of 13 studies described the initial development and testing of AI algorithms, and 3 studies described the validation of an AI algorithm in independent data sets. One study was based on prospectively collected data; only 3 studies were based on primary care data. We found no data on implementation barriers or cost-effectiveness. Risk of bias assessment highlighted a wide range of study quality. The additional scoping review of commercial AI technologies identified 21 technologies, only 1 meeting our inclusion criteria. Meta-analysis was not undertaken because of the heterogeneity of AI modalities, data set characteristics, and outcome measures.

Conclusions
AI techniques have been applied to EHR-type data to facilitate early diagnosis of cancer, but their use in primary care settings is still at an early stage of maturity. Further evidence is needed on their performance using primary care data, implementation barriers, and cost-effectiveness before widespread adoption into routine primary care clinical practice can be recommended.
The Cellars of Lubyanka. The Memories of Ivan Ilyin
Authors: Vakulinskaya Alexandra I. 
Published: November 2020

This publication presents two texts by I.A. Ilyin, jointly entitled “On the Prayer” and kept among other miscellaneous materials in the archive of the philosopher at the Scientific Library of Lomonosov Moscow State University. The author of the article carries our analysis of the sources and on the basis of these texts reconstructs additional facts of the biography of I.A. Ilyin.
V.V. Rozanov’s Archive in Rumyantsev Museum
Authors: Lomonosov Aleksey V. 
Published: November 2020

The article presents a general overview of the letters to V.V. Rozanov that he sent to . Rumyantsev Museum. The chronology of the receipt of materials from the epistolary archive to the Department of manuscripts of the Museum is traced. The author refers to the names of the persons who directly handed the materials to the archive, and who accepted and processed them. The bibliophilic priorities of the museum curator . G.P. Georgievsky and V.V. Rozanov became the basis for supplementing the epistolary collection “From the Archive of V.V. Rozanov”. The author mentions the error in dating the letter of V.V. Rozanov to G.P. Georgievsky., written to accompany the last part of the epistolary passed to the Museum inter vivos. The text of the letter is published for the first time. The importance of V.V. Rozanov’s review of the book in the “Novoye Vremya” journal at the beginning of the twentieth century is emphasized. The author’s approach to the systematization of the correspondents’ letters for their subsequent passing over to Rumyantsev Museum is shown. The author provides concise information on the contents of certain collections of letters from Rozanov’s correspondents. The main themes of V.V. Rozanov’s epistolary communication with the authors of the letters are outlined. The author takes note of Rozanov’s special attitude to the selection of letters from the archive of correspondence for further publication. in the “Literary Exiles” series.. In the forefront there are letters from Church leaders and the thinker’s allies in the field of legislation on family relations. The article highlights the problem of correctness of specifying archive code numbers of the Russian State library’s manuscript department from the museum part of the archive, which have undergone changes during their stay in the General complex of V.V. Rozanov’s manuscript archive.
V.V. Rozanov’s Concepts of the Russian Life Ideal Fundamentals
Authors: Zakharova Victoria T. 
Published: November 2020

The article is devoted to revealing in the views of V.V. Rozanov the positive elements of the domestic life and ideal beginnings of Russian life, – both in synchronic and diachronic plans. Various works of the writer and philosopher became the objects of the study: books belonging to the genre of “prose of fragments”, journalistic essays, “Russian Nile” travel essay, articles and reviews of the art criticism character. The analysis showed how important for the philosopher was the idea of the essentiality of preserving those spiritual and cultural national traditions that had always been the key to the sustainability of life.
Topics of Russian Nationalism in Ecclesiastic Journalism in the Second Half of the 19th and the Beginning of the 20th Century
Authors: Ivanov Andrey A.  
Published: November 2020

The article deals with the attitude of the orthodox ecclesiastic authors of the second half of the 19th and the beginning of the 20th century (clergy, theologians, journalists) toward such phenomenon of the social and political life of Russian society as nationalism. On the basis of articles and sermons published in eparchial media outlets, religious journals, newspapers and individual brochures, the article reconstructs and analyzes the insights of ecclesiastic journalists in the problem of relationship in Orthodox Christianity between the universal and the national; their ideas of nation and nationalism; the attitude toward cosmopolitanism. Special attention is paid to the issue of the existence of national Orthodox churches as integral parts of the unique Christian Church, to the craving of Orthodox nations for cultural and political separation, and acceptability of nationalism for Orthodox Christians. The author of the article argues that in spite of opinions pluralism regarding these issues, the judgment of the Church representatives about nationalism had much in common which allows to speak about the zeitgeist in assessments of the place of the national in Orthodox Christianity developed in that period of time in the Russian ecclesiastic environment. While not doubting the “universality” of Orthodox Christianity and denouncing national intolerance and “secular” nationalism of West European-style, the majority of ecclesiastic journalists, at the same time, criticized cosmopolitanism and tried to direct Russian nationalism, that was gaining popularity in society, to the ecclesiastic track, placing it at the service of Christianity.
Father Johnof Kronstadt and St. Petersburg Metropolitan Isidore (Nicolsky). From the Diary of the Capital’s Metropolitan
Authors: Beglov Alexey L. 
Published: November 2020

The article is devoted to the study of the relations of Father John of Kronstadt and his diocesan Bishop – Metropolitan Isidore of Saint Petersburg (Nikolsky; 1799-1892), an outstanding pastor of his era. For the first time a unique historical source – the diary of Metropolitan Isidore – is used to study the relationship between Kronstadt pastor and a representative of the Orthodox hierarchy. The author of the article comes to the conclusion that in the diary we do not see any obvious hostility towards Father John. The tone of the notes in relation to him is rather neutral. The sarcasm of the author of the diary is directed at the admirers of Father John, primarily the representatives of the nobility. It can be concluded that Metropolitan Isidore did not have any personal attitude to Father John before 1883 as Isidore was hardly acquainted with him. In general, the figure of the Kronstadt pastor interested the Metropolitan only so far as he appeared in the public field and on the pages of newspapers, generated rumors, and was mentioned by influential people. At the same time, the diary entries, related to Father John were largely based on such rumors and conversations passed on to the Metrpolitan by those close to him.
Effects of Neoadjuvant Chemio-Radiation Therapy on the Anal Sphincter Function in Patients with Low Rectal Cancers
Authors: Baichorov A. B. , Rasulov A. O. 
Published: November 2020

The aim of the study was to compare functional results prior to and following neoadjuvant chemoradiation therapy.Materials and methods. An analysis of the functional results of a prospective clinical study was carried out. The study included 90 patients who underwent low anterior rectal resection for cancer of the lower or middle ampullar rectum with T1-4aN0-2M0 using various reconstruction methods.Results and discussion. Group A included 22 patients with J-shaped reservoirs; group B — 30 patients with side-to-end anastomoses; group C — 38 patients with end-to-end anastomoses. Out of the total study group (n = 90), 43 patients underwent neoadjuvant chemoradiotherapy vs. 47 patients without any preoperative treatment. No statistically significant difference was observed in the frequency of applied reconstructive techniques (р = 0.725) and the incidence of postoperative complications (p = 0.103) in the groups with and without neoadjuvant chemoradiotherapy. The baseline scores of the Wexner scale and the results of anorectal manometry in the comparison groups were comparable (p > 0.05). However, upon completion of neoadjuvant chemoradiotherapy and during the period from the moment of surgery up to 12 months after the closure of preventive intestinal stomas, the functional results were less satisfactory in the group of patients having received neoadjuvant chemoradiotherapy (n = 43) with regard to the comparison group (n = 47). Nevertheless, a statistically significant difference in the results was observed from the end of neoadjuvant chemoradiotherapy up to 3 months after closure of the stoma (p <0.05).Conclusions. Neoadjuvant chemoradiation therapy has a negative effect on the function of the anal sphincter, thus requiring concomitant therapy and physiotherapy both at the stages of neoadjuvant chemoradiotherapy and at long intervals after the main surgical stage.
Regional Chemotherapy Infusion Via the Bronchial Artery in Combined Treatment of Non-Small Cell Lung Cancer
Authors: Gantsev K. Sh. , Isametov D. R. , Arybzhanov D. T. , Timin K. E. 
Published: November 2020

Introduction. Chemotherapy in the form of endovascular infusion or its combination with radiotherapy is a method for treating non-small cell lung cancer (NSCLC), which raises heated discussions among specialists. This study is aimed at assessing the early results of combined treatment of NSCLC patients with selective chemotherapy infusion via the bronchial artery.Materials and methods. A retrospective analysis of treatment results for 24 patients with central pulmonary cancer hospitalized in the Shymkent Oncological Centre (Kazakhstan) during 2016–2019 was carried out. The average age of the patients was 46.4 ± 11.3 years. According to the histological study, 19 and 5 patients were diagnosed with squamous cell lung cancer and undifferentiated carcinoma, respectively. The patients were recognized as surgically incurable; three courses of neoadjuvant polychemotherapy via selective catheterization of the bronchial artery and regional intra-arterial administration of drugs were prescribed according to the DR scheme: Docetaxel 75 mg/m2 , Cisplatin 75 mg/m2 .Results and discussion. Upon completion of three courses of selective chemotherapy, 20 (83.3%) patients showed the possibility of surgical treatment: 15 patients underwent extended pulmonectomy, 5 patients underwent extendedcombined pulmonectomy with pericardial resection with intrapericardial, separate processing of the vessels of the lung root. After the surgical stage, all patients received radiation therapy to the mediastinal area at a single tumour dose of 2 Gy and a total radiation dose of 45–50 Gy. According to an analysis of the mortality and survival rates, 28-day mortality comprised 5% (1 patient, whose death occurred as a result of acute cardiovascular failure); one-year survival rate was 91.6%.Conclusions. Preliminary results of our study show that selective chemotherapy via the bronchial artery increases the frequency of surgical interventions and the overall survival of patients with inoperable pulmonary cancer.
Quantitative assessment of left ventricular volume and function by transthoracic and transesophageal echocardiography, ultrasound velocity dilution, and gated magnetic resonance imaging in healthy foals
Authors: Fries Ryan C. , Clark-Price Stuart C. , Kadotani Saki , Stack Jonathan P. , Schaeffer David J. , Lascola Kara M. 
Published: November 2020

Abstract

OBJECTIVE
To compare measurements of left ventricular volume and function derived from 2-D transthoracic echocardiography (2DE), transesophageal echocardiography (TEE), and the ultrasound velocity dilution cardiac output method (UDCO) with those derived from cardiac MRI (cMRI) in healthy neonatal foals.

ANIMALS
6 healthy 1-week-old Standardbred foals.

PROCEDURES
Foals were anesthetized and underwent 2DE, TEE, and cMRI; UDCO was performed simultaneously with 2DE. Images acquired by 2DE included the right parasternal 4-chamber (R4CH), left apical 4- and 2-chamber (biplane), and right parasternal short-axis M-mode (M-mode) views. The longitudinal 4-chamber view was obtained by TEE. Measurements assessed included left ventricular end-diastolic volume (LVEDV), end-systolic volume (LVESV), ejection fraction, stroke volume (LVSV), cardiac output (CO), and cardiac index (CI). Bland-Altman analyses were used to compare measurements derived from biplane, R4CH, and M-mode images and UDCO with cMRI-derived measurements. Repeatability of measurements calculated by 3 independent reviewers was assessed by the intraclass correlation coefficient.

RESULTS
Compared with cMRI, all 2DE and TEE modalities underestimated LVEDV and LVESV and overestimated ejection fraction, CO, and CI. The LVSV was underestimated by the biplane, R4CH, and TEE modalities and overestimated by UDCO and M-mode methods. However, the R4CH-derived LVSV, CO, and CI were clinically comparable to cMRI-derived measures. Repeatability was good to excellent for measures derived from the biplane, R4CH, M-mode, UDCO, and cMRI methods and poor for TEE-derived measures.

CONCLUSIONS AND CLINICAL RELEVANCE
All assessed modalities yielded clinically acceptable measurements of LVEDV, LVESV, and function, but those measurements should not be used interchangeably when monitoring patient progress.
A Modified Iterative Method for Solving Nonlinear Functional Equation
Authors: Mohit Arya , Amit Ujlayan 
Published: November 2020

Abstract
An iterative method (AIM) is one of the numerical method, which is easy to apply and very time convenient for solving nonlinear differential equations. However, if we want to work in a large interval, sometimes it may be difficult to apply AIM. Therefore, a multistage AIM named Multistage Modified Iterative Method (MMIM) is introduced in this article to work in a large computational interval. The applicability of MMIM for increasing the solution domain of the given problems is construed in this article. Some problems are solved numerically using MMIM, which provides a better result in the extended interval as compared to AIM. Comparison tables and some graphs are included to demonstrate the results.