bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seepage mode in lamina-developed shale oil reservoirs under strong heterogeneous and strong fluid-solid coupling——Taking Jiyang Depression in China as an example
Authors: Yu Chunlei , Zhang Shiming , Chen Ting , Sun Zhigang , Xu Jiaxiang 
Published: December 2024

Abstract

The laminae of different lithologies is a typical sedimentation of shale oil reservoirs, and the resulting strong heterogeneous and strong fluid-solid coupling seriously affect shale oil productivity. Therefore, the strong permeability heterogeneous and mechanical heterogeneous of lamina-developed shale were first qualified by the permeability experiments and quasi triaxial mechanical experiments on shale cores of different directions from Jiyang Depression, which revealed strong brittleness in horizontal cores and elasticity in vertical cores. Then, the strong fluid-solid coupling in lamina-developed shale was investigated by permeability stress sensitivity test and CT scanning, which presents the elasticity deformation of matrix in vertical direction, resulting in dynamic opening and closing of laminae and strong fluid-solid coupling in horizontal direction during the fracturing shut-in and production (FSP). Based on online nuclear magnetic resonance (NMR), fluid migration between pores of different scales and laminae during the FSP was discovered. To detailedly describe the fluid seepage mode in lamina-developed shale oil reservoirs during FSP, an oil-water two-phase flow model coupling shale matrix, laminae and hydraulic fractures was simulated to describe the variation in saturation, pressure, relative permeability, and streamlines of water in lamina-developed shale cores, based on the permeability heterogeneous and stress sensitivity. The results show that During the hydraulic fracturing, the horizontal brittleness and vertical elasticity created a seepage channel of shale matrix, horizontal seams and vertical hydraulic fractures. During the shut-in, the expanded seepage area after the laminae are opened and the extremely high pressure gradient from the seam to the matrix cause the fracturing fluid to invade the matrix and displace some shale oil, gradually balancing the pressure among the three seepage media. During the production, the extremely high pressure gradient shifts from the matrix to seams and hydraulic fractures, and oil and water are simultaneously extracted. However, due to stress sensitivity and relative permeability variation, some fracturing fluids remain in the shale formation.
Use of complement C5-inhibitor eculizumab in patients with infection-associated hemolytic uremic syndrome – a case-series report
Authors: Varga Petra , Biró Erika , Berkes Andrea , Lakatos Erzsébet , Szikszay Edit , Prohászka Zoltán , Szabó Tamás 
Published: December 2024

Abstract

Background: Hemolytic uremic syndrome (HUS), characterized by the triad of microangiopathic hemolytic anemia, thrombocytopenia and acute kidney injury (AKI), remains a leading cause of pediatric AKI. The complement system has a crucial role in the pathogenesis of atypical hemolytic uremic syndrome (aHUS) and eculizumab (ECZ) was approved as standard of care for its treatment. The two widely characterized forms of infection-associated HUS are Shiga toxin-producing E. coli (STEC)-HUS and Streptococcus pneumoniae-associated (SP)- HUS. Extrarenal manifestations such as central nervous system (CNS) involvement occur approximately in 20% of the cases and are accompanied by higher mortality. Abnormalities of the alternative complement pathway may also contribute to the development of both STEC-HUS and SP-HUS, offering a potential treatment option for complement C5 inhibition. Beyond best supportive care as standard therapeutic approach, ECZ has been succesfully used in both STEC-HUS and SP-HUS patients.
We provide further support that early use of ECZ for infection-associated HUS with severe clinical manifestation and abnormal complement-activation profile may be an effective therapeutic approach.
Case presentation: We report on three children (median age: 2 years, range: 2-10 years) diagnosed with infection associated HUS treated with complement C5-inhibitor ECZ. All three patients were treated with ECZ and had excellent outcome. We retrospectively analyzed the clinical course, laboratory data and outcome of children with infection associated HUS treated with ECZ.
Conclusion: In accordance with previous observations ECZ is an efficacious therapeutic choice in severe HUS patients with multiorgan involvement. A detailed complement activation profile, especially sC5b-9, is useful to indicate ECZ administration.
Is Vertebral Bone Quality an Independent Predictor of Total Blood Loss in TLIF Surgery?
Authors: Wang Jingming , Kang Songtao , Wang Lei , Huang Weimin 
Published: December 2024

Abstract

Objective: The purpose of this study is to determine the effect of bone mineral density (BMD), as assessed by preoperative Dual-energy X-ray Absorptiometry (DEXA) scans and MRI-based vertebral bone quality (VBQ), on intraoperative total blood loss following transforaminal lumbar interbody fusion (TLIF).
Methods: Patients who received TLIF for lumbar degenerative diseases at a single academic center from 2023-2024 were included in this study. The preoperative T-score and VBQ score were recorded. Patients with liver/kidney disease or on prescription anticoagulant medication were excluded. Information about operation and blood loss were extracted. Total blood loss during postoperative 3 days was the primary indicator, and secondary indicators included length of hospitalization, hematocrit (HCT) and hemoglobin (Hb), T-score, and VBQ score.
Results: A total of 247 patients (93 males and 154 females) were enrolled in this study, with a mean age of 59.59 ± 9.09 years. VBQ were measured in all patients' preoperative lumbar MRI scans. VBQ (L1-4 median), VBQ (L1-4 average), VBQ (S1) and VBQ (fixation segments) was 3.50±0.70, 3.49±0.67, 3.19±0.72, 3.42±0.71, respectively. Among them, 71 patients had preoperative DEXA of the left hip. The average lowest T-score was -2.25 ± 1.29. The T-score was significantly correlated with the VBQ score (r=-0.331 to -0.419). The average postoperative 3 days' total blood loss was 796.95±569.94ml. Controlling for age, number of fixed segments, preoperative platelet count, and coagulation testing, T-score or VBQ was not correlated with perioperative total blood loss in TLIF.
Conclusions: Preoperative T-score or VBQ score was not correlated with total blood loss in TLIF. The total blood loss of TLIF in multi-segment cases was accompanied by mounts of perioperative hemorrhage, which might lead to longer hospital stays.
Blood basophil concentration at diagnosis, not percentage, correlates with therapy-related outcomes in newly-diagnosed chronic phase chronic myeloid leukaemia
Authors: Faber Edgar , Vrablova Lucia , Zhang Xiao-shuai , Kriegova Eva , Kudelka Milos , Radvansky Martin , Yang Sen , Juranova Jarmila , Papajik Tomas , Gale Robert , Jiang Qian 
Published: December 2024

Abstract

Blood basophils ≥ 20 percent is reportedly associated with a poor prognosis and used to define accelerated phase of chronic myeloid leukaemia (CML) in some classifications. However, quantification of blood basophils is by percentage is inaccurate. Using a Patient Similarity Network (PSM) approach we identified basophil concentration rather than percentage as the more accurate predictive co-variate. To test this observation we interrogated data for a possible correlation between blood basophils quantified by concentration in a training cohort of 131 subjects with newly-diagnosed chronic phase CML receiving tyrosine kinase-inhibitor (TKI)-therapy. Subjects with a basophil concentration ≥ 12.2 x 10E + 9/L had poorer event-free survival (EFS, Odds Ratio [OR] = 12.3 [95% Confidence Interval [CI]. 4.2, 36.1]; p < 0.0001) and failure-free survival (FFS; OR = 10.4 [3.89, 27.72]; p < 0.0001). TKI switch-free survival and progression-free survival were also correlated with basophil concentration. The negative impact of a high basophil concentration was validated in an independent cohort of 1,870 subjects. We explain why basophil concentration is a more accurate co-variate. Our data indicate blood basophil concentration at diagnosis rather than percentage is a more accurate predictor of outcomes in persons with newly-diagnosed chronic phase CML receiving TKI-therapy.
Perceptions of cervical screening uptake amongst South Asian women: A concept mapping study
Authors: Devotta Kimberly , Lofters Aisha , Bender Jacqueline , O'Campo Patricia 
Published: December 2024

Abstract

Background: Regular cervical screening can significantly reduce the onset and prevalence of cervical cancer. In Ontario, Canada, South Asian women have the lowest rates of cervical cancer screening among major ethnic groups in the province.
Methods: Using an innovative and participant-driven method called Concept Mapping (CM), we set out to understand how the lives and experiences of South Asian women living in Ontario shape their decisions around getting screened for cervical cancer. We engaged over 70 South Asian women and people who serve them in healthcare and community, to drive the CM process.
Results: Participants brainstormed 45 unique and distinct statements. Through sorting and map interpretation, participants identified and interpreted 6 clusters amongst the statements: 1) Personal beliefs and misconceptions around cervical cancer; 2) Education and knowledge issues around cervical cancer; 3) Cultural beliefs and influences specific to sexual health; 4) Barriers to prioritizing uptake of cervical screening; 5) System/ infrastructure gaps or inadequacies; and 6) Lack of comfort and supportive relationships in healthcare. Additional analysis shows us the interrelationships between the ideas. Statements within the clusters about education and knowledge issues around cervical cancer, personal beliefs and misconceptions, as well as cultural beliefs and influences specific to sexual health are viewed as distinct beliefs with clear effects on the uptake of cervical screening. More complex interrelationships are seen with the cluster of statements about barriers to prioritizing uptake of cervical screening.
Conclusions: As Ontario and many other jurisdictions around the world seek to strengthen cervical screening efforts in line with national and international goals to eliminate cervical cancer by 2040, it is critical to address underscreening. This CM study recognizes the value of engaging those most impacted by an issue, to identify and prioritize how and where to intervene to address low rates of cervical screening. To address underscreening we need to design multi-level interventions that address the identified ideas and the interrelationships among them.
Higher serum neurofilament light chain levels is associated with hypertension: new discoveries with old disease
Authors: Abudesimu Asiya , Kadier Kaisaierjiang , Siti Dilixiati , Liu Pengfei , Ma Xiang 
Published: December 2024

Abstract

Background: Serum neurofilament light chain protein (sNfL), which is a sensitive marker for early neuronal damage and axonal degeneration, has been shown to be elevated in both neurological and non neurological diseases. However, the relationship between sNfL and hypertension is still unclear.
Methods: This is a cross-sectional study that covering peoples who 20-75 years old from the general US population that participated in the 2013-2014 cycle of the National Health and Nutrition Examination Survey. First, filtering out people with complete information about sNfL and blood pressure value.Then, we conducted multivariate logistic regression analysis to examine the relationship between sNfL and hypertension. Subgroup interactions were analyzed between age, sex, race and hypertension by using likelihood ratio tests, then nonlinear relationships were explored by fitting restricted cubic splines.
Results: A total of 2004 participants (988 with and 1016 without hypertension) with average age 45.03 years old were included in this study. After adjusting for potential confounders; Log-sNfL is positively correlated with hypertension (OR, 1.55; 95% CI, 1.16–2.06). Then, we further evaluated the relationship between quartiles of sNfL and hypertension, the ORs with 95% CIs for hypertension across the second to fourth quartiles were 1.38 (0.91to 2.11), 1.76 (1.22 to 2.53) and 2.15 (1.17 to 3.96) for Log-sNfL (Pfor trend 0.037) compared with the lowest quartile. In the subgroup analyses the likelihood ratio test showed no multiplicative interaction (all P value for interaction >0.05), showing that above results are stable across age, sex and race. Additionally, restricted cubic splines confirmed a linear relationship between Log-sNfL and hypertension (Pfor non-linearity = 0.406).
Conclusions: Higher level of sNfL is associated with a higher risk of hypertension in the US population aged 20-75 years old, this requires further large-scale prospective studies for confirmation.
FLNB and TTC26 target ciliary hedgehog signaling to mediate extracellular matrix homeostasis of intervertebral disc in adolescent idiopathic scoliosis Running Title：FLNB and TTC26 regulate ntervertebral disc degeneration
Authors: Jiang Heng , Gao Yuan , Lai Bowen , Wu Jinhui , Liao Taotao , Zhang Zheng , Zhou Xin , Zhao Jianquan , Meng Yichen , Cai Zhuyun , Zhang Chenglin , Lai Suomei , Gao Rui , Wang Ce , Li Jinsong , Yang Fu , Ding Yifu , Zhou Xuhui 
Published: December 2024

Abstract

Variable recurrence risk and curve manifestations in adolescent idiopathic scoliosis (AIS) has been ascribed to the oligogenic effect of multiple genes. However, evidence to support this hypothesis is currently lacking. In this study, we generated mice carrying double heterozygous mutations by injecting mouse androgenic haploid embryonic stem cells with mutant Flnb and Ttc26 into oocytes. The double heterozygous mutant mice exhibited IS-like phenotypes. Combined knockdown of FLNB and TTC26 resulted in dysregulated extracellular matrix (ECM) homeostasis of intervertebral disc (IVD) consistent with the analysis of the nucleus pulposus (NP) tissues from AIS patients. In vitro evidence indicated that FLNB and TTC26 co-regulated nucleus pulposus cells ECM metabolism via the hedgehog pathway (Hh). Mechanically, TTC26 transported the protein arginine methyltransferases 7 (PRMT7) into primary cilia where PRMT7 methylates GLI family zinc finger 2 (GLI2), and FLNB imported methylated GLI2 into nucleus through direct interaction. Furthermore, deletion of Ptch1 or Sufu stimulated the Hh signaling to rescue the metabolic disorder in Flnb−/+; Ttc26−/+ discs. Overall, these results indicate that FLNB and TTC26 maintain IVD ECM hemostasis via Hh-GLI2 axis, and demonstrate that IVD may be involved the etiology of AIS.
A Stepwise Decision Tree Model for Differential Diagnosis of Kimura's Disease in the Head and Neck
Authors: Luo Rui , Yang Gongxin , Shi Huimin , He Yining , Han Yongshun , Tian Zhen , Wu Yingwei 
Published: December 2024

Abstract

Objectives:This study aims to differentiate Kimura's disease (KD) from Sjogren's syndrome with mucosa-associated lymphoid tissue lymphoma (SS with MALT lymphoma), neurofibromatosis (NF), and lymphoma in the head and neck using a stepwise decision tree approach.
Materials and Methods: A retrospective analysis of 202 patients with pathologically confirmed KD, SS with MALT lymphoma, NF, or lymphoma was conducted. Demographic and MR data were collected, with qualitative features (e.g., skin thickening, lesion morphology, lymphadenopathy, MR signal intensity) and quantitative variables (e.g., age, lesion size, apparent diffusion coefficients (ADCs）, wash-in rate, time to peak (TTP), time-signal intensity curve (TIC)patterns) examined. A stepwise decision-tree model using the Classification and Regression Trees (CART) algorithm was developed for differential diagnosis accuracy and misclassification risk assessment.
Results: Key characteristics for KD included male predominance (91.7%), frequent lymphadenopathy (86.1%), and skin thickening (72.2%). NF primary lesions had higher ADC values compared to KD, SS with MALT lymphoma, and lymphoma. Lymphadenopathy exhibited unique ADC features, with lower values than KD primary lesions but similar to lymphoma lesions. Predictors for distinguishing KD included lesion location, ADCs, lymphadenopathy presence, and size (p < 0.001). The decision-tree model achieved 99.0% accuracy in differential diagnosis, with a 10-fold cross-validated misclassification risk of 0.079 ± 0.024.
Conclusions: The stepwise decision tree model, based on MR imaging features, shows high accuracy in differentiating KD from other head and neck diseases, offering a reliable diagnostic tool in clinical practice.
Clinical Relevance: KD is characterized by male predominance, skin thickening, and high incidence of lymphadenopathy. ADCs and TIC patterns are distinguishable in differentiating KD from SS with MALT lymphoma, NF, and lymphoma in the head and neck. The decision tree model enhances the understanding of KD imaging features and facilitate accurate KD diagnosis, offering an easily accessible and convenient diagnostic tool for radiologists and physicians in daily practice and guiding tailored clinical management plans for affected patients.
Methodology for Pediatric Head Computed Tomography Image Segmentation and Volumetric Calculation Using a Tablet Computer and Stylus Pen
Authors: Hashimoto Hiroaki , Shimada Makoto , Takemoto Osamu , Chiba Yasuyoshi 
Published: December 2024

Abstract

Purpose This study presents a MATrix LABoratory (MATLAB)-based methodology for calculating intracranial volumes from head computed tomography (CT) data and compares it with established methods.
Methods Regions of interest (ROI) were manually segmented on CT images using a stylus pen, facilitated by mirroring a computer desktop onto a tablet. The volumetric process involved three main steps: (1) calculating the volume of a single voxel, (2) counting the total number of voxels within the segmented ROI, and (3) multiplying this voxel count by the single-voxel volume. This method was applied to 83 pediatric head CT scans from patients with minor head trauma, and the volumetric results were compared with those obtained from OsiriX.
ResultsA paired t-test revealed a statistically significant difference (p < 0.001) between the volumes obtained with our MATLAB-based method and those from OsiriX. However, the volumes obtained by our method were only 0.32% higher than the OsiriX measurements.
ConclusionAlthough a statistically significant difference was found between our method and OsiriX, the discrepancy is minimal and practically negligible. The MATLAB code provided in this study may serve as a valuable tool for beginners in radiological research.
Efficacy of ileus tube combined with gastrografin in treating post- cesarean ileus
Authors: Zhang Ziqiu , Li Zhaoxue , Shao Guoqing , Liu Shengzhong , Du Hongtao , Li Dechun 
Published: December 2024

Abstract

Aim
This study aimed to assess the effectiveness of an ileus tube combination with gastrografin for treating post-cesarean ileus.
Method
A retrospective case series study was performed. Patients who underwent ileus tube insertion in combination with gastrografin for post-cesarean ileus at Xuzhou Central Hospital between April 1, 2014, and April 30, 2024, were included. The primary outcome indicators included the catheterization success rate, symptom relief rate, obstruction release rate, catheterization complications, and recurrence results during follow-up.
Results
This study involved 17 patients with post-cesarean ileus, of whom 12 underwent transnasal ileus tube catheterization, and 5 underwent transanal ileus tube catheterization. The catheterization success rate and symptomatic relief for 17 patients was 100% (17/17), the blockage alleviation rate was 94.12% (16/17), the incidence of minor problems was 23.53% (4/17), and the incidence of serious complications was 0% (0/17). Obstruction relief was not achieved in 1 patient because of an intestinal perforation detected during ileus tube catheterization, with a subsequent referral for emergency surgery. Seventeen patients were followed up, and one patient experienced a recurrence of intestinal obstruction (5.88%), which was relieved by conservative treatment. No further obstruction recurrences were observed during the follow-up period.
Conclusion
The ileus tube combined with gastrografin is safe and effective in treating post-cesarean ileus. It has a low recurrence rate and minor complications. It is a viable approach for the conservative treatment of post-cesarean ileus.
WITHDRAWN: Unveiling the continuum of acute-on-chronic liver failure: phenotypic insights into severity and outcomes
Authors: Zhang Qian , Hu Jiaxuan , Qiu Shaotian , Bian Jiale , Gao Aimin , Liu Fang , Zhao Caiyan , Zhang Liaoyun , Ren Wanhua , Xin Shaojie , Chen Yu , Duan Zhongping , Han Tao 
Published: December 2024

Abstract

Background and Aims:
Recently, Kulkarni and Sarin introduced a novel framework for the Acute-on-Chronic Liver Failure (ACLF) continuum, ranging from the European Association for the Study of the Liver (EASL) pre-ACLF stage to the more severe EASL-Chronic Liver Failure (EASL-CLIF) ACLF stage, illustrating progressive severity. This study aims to evaluate and validate phenotypic classifications and outcomes across the ACLF spectrum, focusing on Hepatitis B Virus (HBV) and alcohol-related aetiologies.
Methods:
A multi-center retrospective analysis of 955 patients classified into EASL pre-ACLF and EASL-CLIF ACLF subgroups was conducted. Clinical features, outcomes, and prognostic accuracy of scoring systems for 28-day and 90-day mortality were compared.
Results:
Of 955 enrolled patients, 659 (69.01%) had HBV-related and 296 (30.99%) had alcohol-related chronic liver disease. Across the entire study population and within HBV and alcohol stratified groups, 28-day and 90-day mortality rates were significantly higher in EASL-CLIF ACLF patients compared to EASL pre-ACLF patients. The MELD-sodium (MELD-Na) score was a more accurate predictor of 28-day and 90-day mortality for EASL pre-ACLF patients, whereas the Chronic Liver Failure-Consortium ACLF (CLIF-C ACLF) and Chinese Group on the Study of Severe Hepatitis B-ACLF II (COSSH-ACLF II) scores were superior for EASL-CLIF ACLF patients.
Conclusions:
The proposed phenotypic classification for the ACLF continuum, stratified by severity stages, effectively distinguishes clinical features and prognosis across different aetiologies. Distinct prognostic scoring systems demonstrated different emphases at each stage of ACLF, thereby enabling more accurate prognostic predictions and advancing treatment strategies.