bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of the CytoSorb adsorption device in MDMA intoxication: a first-in-man application and in vitro study
Authors: Lang Corinna N. , Sommer Michaela J. , Neukamm Merja A. , Staudacher Dawid L. , Supady Alexander , Bode Christoph , Duerschmied Daniel , Lother Achim 
Published: June 2020

Abstract
Background
3,4-Methylenedioxymethamphetamine (MDMA, “ecstasy”) abuse is frequent, and overdosing might cause severe and eventually lethal multi-organ failure. To date, there is no causal therapy of MDMA intoxication and removal of MDMA from the circulation might be a reasonable measure to prevent adverse courses after overdosing. We present here first-in-man experience and in vitro data supporting a potential role of an adsorber device in severe MDMA overdosing.

Results
We applied a CytoSorb adsorber device in a 21-year-old male presenting with severe MDMA intoxication and multi-organ failure, including neurological impairment, hyperpyrexia, rhabdomyolysis, oliguric renal failure, liver failure, and coagulopathy with disseminated gastrointestinal and intramuscular bleeding. Use of the adsorber device was associated with a decline in MDMA concentrations in serum from 540 to 140 ng/ml within the first 24 h, a decrease of interleukin 6 and myoglobin levels, and subsequent clinical improvement. The patient was discharged from hospital after restoration of organ function and full neurological recovery. Effective elimination of MDMA by the adsorber device could be confirmed in vitro, when the device lowered MDMA concentrations to non-detectable levels.

Conclusions
We report here first-in-man experience and in vitro data showing the capacity of a CytoSorb adsorber device for MDMA removal. Early integration of CytoSorb use may enhance the management of severe MDMA intoxication, though we cannot prove whether clinical improvement was directly related to elimination of MDMA or beneficial effects on rhabdomyolysis, hyperinflammation, or liver failure. Our findings encourage further investigation of the CytoSorb adsorber device in a prospective study and to evaluate its use for other intoxications.
Study protocol for POSITIF, a randomised multicentre feasibility trial of a brief cognitive-behavioural intervention plus information versus information alone for the treatment of post-stroke fatigue
Authors: Gillespie David C. , Barber Mark , Brady Marian C. , Carson Alan , Chalder Trudie , Chun Yvonne , Cvoro Vera , Dennis Martin , Hackett Maree , Haig Euan , House Allan , Lewis Steff , Parker Richard , Wee Fiona , Wu Simiao , Mead Gillian 
Published: June 2020

AbstractBackgroundApproximately, half of stroke survivors experience fatigue. Fatigue may persist for many months and interferes with participation in everyday activities and has a negative impact on social and family relationships, return to work, and quality of life. Fatigue is among the top 10 priorities for ‘Life after Stroke’ research for stroke survivors, carers, and clinicians. We previously developed and tested in a small uncontrolled pilot study a manualised, clinical psychologist-delivered, face-to-face intervention, informed by cognitive behavioural therapy (CBT). We then adapted it for delivery by trained therapists via telephone. We now aim to test the feasibility of this approach in a parallel group, randomised controlled feasibility trial (PostStrokeInterventionTrialInFatigue, POSITIF).Methods/designPOSITIF aims to recruit 75 stroke survivors between 3 months and 2 years post-stroke who would like treatment for their fatigue. Eligible consenting stroke survivors will be randomised to either a 7-session manualised telephone-delivered intervention based on CBT principles plus information about fatigue, or information only. The aims of the intervention are to (i) provide an explanation for post-stroke fatigue, in particular that it is potentially reversible (an educational approach), (ii) encourage participants to overcome the fear of taking physical activity and challenge negative thinking (a cognitive approach) and (iii) promote a balance between daily activities, rest and sleep and then gradually increase levels of physical activity (a behavioural approach). Fatigue, mood, quality of life, return to work and putative mediators will be assessed at baseline (just before randomisation), at the end of treatment and 6 months after randomisation. POSITIF will determine the feasibility of recruitment, adherence to the intervention and the resources required to deliver the intervention in a larger trial.DiscussionThe POSITIF feasibility trial will recruit until 31 January 2020. Data will inform the utility and design of a future adequately powered randomised controlled trial.Trial registrationClinicalTrials.gov,NCT03551327. Registered on 11 June 2018.
(Dis)connecting migration: transnationalism and nationalism beyond connectivity
Authors: Nowicka Magdalena 
Published: June 2020

AbstractTransnationalism as a perspective that scrutinizes localities in more than one nation-state has helped to illuminate those aspects of lives of migrants that remain hidden when migration is seen through the lens of conventional migration theory. Social connectivity provides a context in which effects of migration can be studied. Yet reducing transnationalism to connectivity is unproductive for understanding current-day sociality as possibly distinct from a national one. This paper proposes to consider how nationalism is embedded in migrants’ ‘deep stories’, and how these stories are altered in migration. It exemplarily analyses narrations from interviews with Polish migrants in England. The paper argues that connectivity and social context are equally important for transnationalism, but transnationalism cannot be reduced either to one or the other. In turn, we must define transnationalism as outcome of multiple belongings, practise and dispositions coming together.
Personalized accessible wayfinding for people with disabilities through standards and open geospatial platforms in smart cities
Authors: Wheeler Bradley , Syzdykbayev Meirman , Karimi Hassan A. , Gurewitsch Raanan , Wang Yanbo 
Published: June 2020

AbstractOf the many features that smart cities offer, safe and comfortable mobility of pedestrians within the built environment is of particular importance. Safe and comfortable mobility requires that the built environments of smart cities be accessible to all pedestrians, mobility abled and mobility impaired, given their various mobility needs and preferences. This, coupled with advanced technologies such as wayfinding applications, pedestrians can get assistance in finding the best pathways at different locations and times. Wayfinding applications comprise two components, a database component containing accessibility data, and appropriate algorithms that can utilize accessibility data to meet the mobility needs and preferences of all individuals. While wayfinding applications that provide accessibility on both permanent (e.g., steps) and temporary (e.g., snow) pathways are becoming available, there is a gap in current solutions. There are two elements in the gap, one is that the accessibility data used for finding accessible pathways for people with disabilities are not compliant to the widely agreed upon and available standards, another is that the accessibility data are not available in free and open platforms so that they can be used by developers to develop personalized wayfinding applications and services. To fill this gap, in this paper, we propose a new extension in CityGML with accessibility data. We demonstrate the benefits of the new extension by testing various route options within a city. These route options clearly show the differences between commonly (shortest and fastest) requested and produced pathways and accessible pathways that are feasible and preferred by people who are mobility impaired, such as wheelchair users.
In vitro hypoxia responsiveness of [18F] FDG and [18F] FAZA retention: influence of shaking versus stagnant conditions, glass versus polystyrene substrata and cell number down-scaling
Authors: Busk Morten , Horsman Michael R. , Overgaard Jens , Jakobsen Steen 
Published: June 2020

Abstract
Background
In vitro experiments using radiolabeled molecules is fundamental for Positron emission tomography (PET) or single photon emission computed tomography (SPECT) tracer development and various metabolic assays, but no consensus on appropriate incubation conditions exists. Specifically, the use of shaking versus non-shaking conditions, cell number to medium volume and the choice of cell plating material may unintentionally influence cellular oxygenation and medium composition. This is problematic when testing the oxygen-dependence of tracers including 18F-fluoro-2-deoxyglucose ([18F]FDG) and hypoxia-selective 2-nitroimidazoles (e.g., 18F-fluoroazomycin-arabinoside, [18F]FAZA) or when doing prolonged experiments. The purpose of this study was to assess the influence of various experimental conditions on tracer retention.

Methods
Tumor cells were seeded in a) Glass or standard Polystyrene Petri dishes or as b) discrete droplets in polystyrene Petri dishes or on 9 mm glass coverslips positioned in glass Petri dishes. When confluent, cells were pre-equilibrated for 2 h to 21%, 0.5% or 0% O2 and [18F] FDG or [18F] FAZA was added, followed by cell harvest and analysis of radioactivity 1 h ([18F]FDG) or 3 h ([18F]FAZA) after. Experiments were conducted with/without orbital shaking.

Results
The influence of hypoxia on tracer retention varied widely among cell lines, but shaking-induced convection did not influence uptake. In contrast, hypoxia-driven [18F] FAZA, and to some extent [18F] FDG, retention was much lower in cells grown on polyethylene than glass. Scaling-down the number of cells did not compromise accuracy.

Conclusions
Tracer retention was similar under stagnant and forced convection conditions suggesting that the former approach may be appropriate even when accurate control of oxygen and tracer availability is required. In contrast, conventional plasticware should be used with caution when studying tracers and drugs that are metabolized and retained or activated at low O2 levels. Downscaling of cell number, by reducing the effective growth area, was feasible, without compromising accuracy.
What Do Patients With Non–Small-Cell Lung Cancer Experience? Content Domain for the MD Anderson Symptom Inventory for Lung Cancer
Authors: Whisenant Meagan S. , Williams Loretta A. , Garcia Gonzalez Araceli , Mendoza Tito , Shi Qiuling , Cleeland Charles , Zhang Jianjun , Heymach John , Simon George 
Published: June 2020

PURPOSE: Symptom monitoring has demonstrated improved outcomes in patients with cancer, including quality of life, resource utilization, ability to continue treatment, and survival. The use of disease-specific patient-reported outcome (PRO) measures facilitates symptom monitoring. While the MD Anderson Symptom Inventory–Lung Cancer (MDASI-LC), a PRO measure of symptom burden in lung cancer, is psychometrically validated for use in patients with NSCLC, its content validity has not been verified through direct patient input. Our purpose is to describe the symptom experience of patients with NSCLC and to confirm that the MDASI-LC contains the key symptoms specific to NSCLC from the patient perspective. METHODS: Patients with NSCLC described their symptom experience in single qualitative interviews. Content analysis was used to define the content domain for a PRO measure of NSCLC symptom burden. RESULTS: Participants (N = 40) had a mean age of 66.1 years (standard deviation, 10.9 years); 60.0% were male, 77.5% were White, and 56.4% had stage IV disease. Thirty-two symptoms were described, with 6 reported by ≥ 20% of participants. Symptom variations were noted by treatment modality but not by stage of disease. Patients with NSCLC commonly reported shortness of breath, cough, distress, fatigue, pain, and constipation. In patients receiving chemotherapy, treatment-related symptoms, including neuropathy and sore mouth, were commonly noted. The presence of these symptoms resulted in interference with daily activities, relationships, life plans, treatment adherence, and mood. CONCLUSION: The symptoms included in the MDASI-LC are important components of the content domain of an NSCLC symptom burden measure. The presence of these symptoms affect daily life and, therefore, is of clinical consequence.
Providing Oncology Pharmacy Services During the Coronavirus Pandemic: French Society for Oncology Pharmacy (Société Francaise de Pharmacie Oncologique [SFPO]) Guidelines
Authors: Pourroy Bertrand , Tournamille Jean Francois , Bardin Christophe , Slimano Florian , Chevrier Régine , Rioufol Catherine , Madelaine Isabelle 
Published: June 2020

PURPOSE: Patients with cancer are at higher risk for contracting the COVID-19 infection and are more likely to have higher morbidity and mortality. This is a big challenge for oncology teams that have to treat patients to avoid contamination by SARS-CoV-2. The aim of the current work is to present oncology pharmacy practice guidelines during the COVID-19 pandemic to secure the pharmaceutical care of patients with cancer. METHODS: The bureau of the French Society for Oncology Pharmacy proposed these recommendations according to the French High Authority of Health following the Guidelines of Good Practice, slightly modified according to the pandemic crisis situation. These guidelines were developed by a working group of 7 experts in oncology pharmacy practice. Furthermore, the guidelines were assessed by 31 independent reviewers. RESULTS: One hundred percent of reviewers approved the guidelines and 90% of them suggested some improvements. The final version incorporates the best comments and consists of 26 recommendations organized in 8 different sections. CONCLUSION: These guidelines allow secure pharmaceutical management of patients with cancer during the COVID-19 pandemic.
Effect of Cigarette and Shisha smoking on cognitive functions impairment: A cross sectional study
Authors: Bashir Shahid , Murtaza Ghulam , Meo Sultan Ayoub , Al-Masri Abeer 
Published: June 2020

Objectives: Cigarette and Shisha smoking is becoming a common practice in young generation worldwide. Since, this is a growing threat to public health, our study aims to investigate the cognitive function responses of cigarette and Shisha inhalation in adolescents.
Methods: This retrospective cross sectional study comprised three groups, cigarette smoker, Shisha smoker, and nonsmoker control group (each n=25). All the participants were apparently healthy male volunteers aged 21-24 years. Cognitive functions were assessed by employing “Cambridge Neuropsychological Test Automated Battery”. The cognitive functions outcome variables were response time tasks (attention switching task (AST) and the percentage of correct answers pattern recognition memory (PRM) task.
Results: Cigarette and Shisha smokers exhibited a considerable decline in cognitive performance parameters, AST mean correct latency (p=0.001), AST mean correct latency (congruent) (p=0.001), AST mean correct latency (incongruent) (p=0.001) and AST mean correct latency (switching) (p=0.001) compared to matched control group.
Conclusions: Cigarette and Shisha smokers exhibited significant impairment in their cognitive functions. The present study findings convince that cigarette and Shisha smokers should quit smoking.
doi: https://doi.org/10.12669/pjms.36.5.2251
How to cite this:Bashir S, Murtaza G, Meo SA, Al-Masri A. Effect of Cigarette and Shisha smoking on cognitive functions impairment: A cross sectional study. Pak J Med Sci. 2020;36(5):1042-1047. doi: https://doi.org/10.12669/pjms.36.5.2251
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Jacques Backyard
Authors: Ferreira A. , Raposo I. , Fernandes L. 
Published: June 2020

From a letter to the School's director “What I think about my school”, students identified problems and designed a project in order to have direct intervention in the solution. Under the theme "Biodiversity", the project aimed to create an "edible garden" at school and involved different activities: planting trees, identifying the existing ones, growing vegetables, composting and collecting rainwater for irrigation, where some of them. The construction of the gardens respected the underground life and the planting was done taking into account the intercropping of plants. Whenever possible, the project was linked to the students' curriculum. The project also had an artistic aspect: students and elderly people graffitied one of the walls next to the vegetable gardens, taking advantage of an autarchy project entitled “Active aging”.
HawkRadon
Authors: Saraiva A. P. , Lourenço A. M. , Soares B. , Monteiro D. , Grilo D. , Saraiva T. 
Published: June 2020

In this project, the students decided to measure the values of radon in the water and in the air in different points of our city and, at the same time, warn people about the consequences of high values. We placed several detectors to measure the values of radon concentrations and concluded that some of the values were well above the reference values. The project was only possible due to the unconditional help of the city council of Pinhel, the LabExpoRad of BeiraInterior University and the students that attended our school last year. We think that this work represents a school open to an open society.
Bees for the Future
Authors: Freitas A. , Ferreira C. , Campanário C. , Freitas F. 
Published: June 2020

In the academic year 2018/2019, students from Escola Secundária Jaime Moniz studied the importance of bees for the future using digital tools, platforms, and a simulator that represented the influence of the increase or decrease of flowers to the bee population and the other way around. They also established collaboration with their community to research theirlevel of awareness, to collect knowledge from experts, and to analyze the health of the bee population in their island. For this, they collected information in a series of forms, which they shared in the Globallab platform with students from other parts of the world, gaining awareness of the relevance of problems at local and global levels. In the process, studentsvisited a honey producer and organized a conference with the beekeeper. In the end, each group of students created a final product to present to the educational community, raising awareness of the problem studied. The products created were posters, leaflets, models, games, beds of honey plants, hives, and hotels for bees.
UV: Friend or Foe?
Authors: Santos A. , Pontes C. , Chaves E. , Oliveira F. , Ribeiro M. , Abreu R. , Visinho T. 
Published: June 2020

For about four months, in the 2018-2019 school year, students from Escola Secundária Jaime Moniz were involved in the project “UV-friendly or enemy?”. The project went through various activities that promoted interdisciplinarity between the disciplines of Physics, Chemistry, Biology and Geology, and established contacts with their community. They also had the chance to conduct surveys and share the responses obtained on the Goballab platform, gaining awareness of the relevance of the problems associated with sun exposure at local and global levels. In the end, each group of students from each of the classes, created a product to present to the educational community, raising awareness of the problem studied. The products created were: posters, leaflets, games and a song (original lyrics and music) warning about the dangers and benefits of ultraviolet radiation for human health and the use of sunscreens.
A Pedestrian Route to Soeiro
Authors: Graça C. , Macieira C. , Almeida F. , Manso L. 
Published: June 2020

The project aimed to requalify the space between the S. António river and the Arruda road, creating access to the Soeiro Pereira Gomes school, protecting it from motor vehicles. A pedestrian route was outlined and creative solutions of urban furniture (bench, garbage can, lighting and drinking fountain) to be placed along the route were developed. The municipal entities were involved, however only the President of the Union of Parishes was available for the implementation of the project.
How to Recover Lost Traditions?
Authors: Teixeira E. 
Published: June 2020

The aim of the project was to engage the community into the recovery and revitalization of some traditional trades and crafts that are at risk of disappearing. At the same time we intended to make students aware of the lost traditions from previous generations that with time are going to be lost. When visiting the place where the black clay of Bisalhães is produced(Intangible Cultural Heritage of Humanity by UNESCO) we realized that there are not enough potters. We went to explore the pottery extraction and production processes and we organized a traditional fair where we exposed all the pottery pieces made by students, so all the community could be aware of Bisalhães pottery. With our enthusiasm we awake the community curiosity for the beauty of traditions.
Learn to Eat and Get a Move On
Authors: Calvo I. , Leão I. , Nunes I. , Morgado J. , Pacheco R. , Cabaço T. , Magalhães T. 
Published: June 2020

Healthy dieting and the practice of physical activities are deemed fundamental for the adequate growth, development and maintenance of health in young people. This project takes into account these priority areas and is directed towards the educational community, giving a voice to the students through projects such as "Ambassadors of Health" and "E- P@articipate". With "Learn to Eat and Get a Move On" a transversal involvement between community partners, projects and disciplinary areas were achieved, namely through the projects "Mediterranean Diet", "Geodesic Greenhouse" and physical education, with activities being developed in the areas of diet, health and environment. In the greenhouse, aromatic seeds were planted to highlight their importance in a diet, as well as a way to reduce or replace salt.
Cáster River (Ovar, Portugal): Evaluate to Recover
Authors: Polónia R. , Santos J. R. 
Published: June 2020

The Cáster is the largest river in the Municipality of Ovar, flowing into the northern arm of the Ria de Aveiro (a coastal Haff-Delta). It constitutes a threatened ecosystem that has suffered a marked degradation of water quality, a decrease in biodiversity, an increase in human pressure on the margins, and several problems in the regularity of the flow itself. In this project we intend to evaluate, through physical-chemical and biological methods, the quality of the water, monitor fluctuations in flow rates, identify polluting sources, and, based on the data collected, develop intervention proposals, in support of local entities. In partnership with the Science Club, some devices (Arduino and Raspeberry enabled) are being developed for continuous remote monitoring of different areas of the river.
Vegetable Selection and Storage: a New Food Concept
Authors: Pereira S. G. , Chairuca B. , Rossini L. , Andrade M. , Fenhane S. , Caravela S. , Laisse W. , Yassin Y. , Silva B. , Chaves B. , Mijares D. , Tenreiro L. -N. , Oliveira R. , Cuambe N. 
Published: June 2020

A problem of malnutrition has been identified in Mozambique, specifically in Ponta de Ouro Marine Reserve. The project embraces the selection, conservation and preparation of packages of dehydrated vegetables (Corn, cassava, beans, moringa and peanuts), that contain the widest range of nutrients possible, easy to produce and prepare: Xima1 enriched. Thereby, we hope to improve the cognitive, intellectual and motor development of children and the community in general. Xima is a ground corn flour that's turn into a sort of porridge. It is eaten all over sub-Saharan Africa.