bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is cardiotrophin-1 a new risk factor of atrial fibrillation in patients with visceral obesity and metabolic syndrome?
Authors: Ionin V. A. , Zaslavskaya E. L. , Petrishcheva E. Y. , Barashkova E. I. , Skuridin D. S. , Filatova А. G. , Baranova E. I. 
Published: August 2020

Objective. To determine the concentration of cardiotrophin-1 (CT-1) in patients with metabolic syndrome (MS) and atrial fibrillation (AF) and the relationship with the parameters of obesity and metabolic disorders.Design and methods. In the one-stage case-control study, 352 subjects (35-65 years old) were included: patients with MS (n = 223), among them 107 patients had AF, and two comparison groups consisted of patients with AF without MS (n = 69) and otherwise healthy individuals (n = 60).Results. The serum concentration of CT-1 in patients with AF and MS is higher compared to patients with MS without AF (851,2 (589,1-1146,3) and 590,2 (480,1-922,3) pg/ml, p = 0,005) and healthy subjects (851,2 (589,1-1146,3) and 410,1 (290,2-549,2) pg/ml, p < 0,0001). Patients with AF and MS showed higher serum levels of CT-1 than patients with AF without MS (851,2 (589,1-1146,3) and 681,1 (480,1-823,2) pg/ml, p = 0,004). CT-1 positively correlated with plasma levels of glucose (p = 0,423, p = 0,002) and triglycerides (p = 0,207, p = 0,003), as well as with the waist circumference (p = 0,265, p < 0,001) and the thickness of epicardial fat (p = 0,351, p < 0,001). ROC-analysis demonstrated the increase in serum CT-1 level above 638,1 pg/ml the probability of AF increased by 4 times (odds ratio = 4,0, 95 % confidence interval 2,31-6,94, p < 0,0001).Conclusions. The increase in serum CT-1 concentration is associated with heart remodeling and obesity in patients with MS and probably plays a pathogenetic role in increasing the risk of AF in this cohort of patients.
ANALISIS TERHADAP FAKTOR YANG BERPENGARUH TERHADAP PENERAPAN KEBIJAKAN PENGELOLAAN SAMPAH DI YOGYAKARTA MENGGUNAKAN PEMODELAN SISTEM DINAMIS
Authors: Habibah Erpin , Novianti Febi , Saputra Hanafi 
Published: August 2020

<p><em>In February 2019, the amount of waste in the Piyungan,Yogyakarta, landfill area, was increased. The heap of waste harms to many fields, especially to environmental health. Data from the Department of Public Works Housing and Energy Mineral Resources show that the volume of waste was increased meanwhile the number of landfill areas was significantly decreased, especially from 2017 to 2018. If there is no proper solution, this issue can be a continuous problem and a terrible disaster. The regulations about waste management had been built by government, even some programs in waste management have been launched to solve the waste problem. Nevertheles the real conditions did not accord with the goals. This descriptive study uses statistical methods for processing secondary and primary data which are analyzed based on dynamics system models. The results of this study indicate that the Yogyakarta waste management system is not good enough. The several influencing factors are the government policy is not yet fully known by the whole community, cultural attitudes and awareness of the community to care for waste are still low, and the landfill facilities are still inadequate.</em></p><p><strong> </strong></p><p><strong><em>Keywords:</em></strong><strong> <em>Landfill, Public Awareness, Regulation, Waste Management, Dynamics System.</em><em></em></strong></p><p><strong> </strong></p><p><strong>Abstrak</strong></p><p>Pada Februari 2019 telah terjadi pembengkakan jumlah sampah di area TPA Piyungan, Yogyakarta. Data Dinas Pekerjaan Umum Perumahan dan Energi Sumber daya Mineral, menunjukkan selama kurun waktu 2015-2018 terdapat peningkatan jumlah volume sampah yang dihasilkan, sementara jumlah TPA mengalami penurunan yang signifikan terutama dari tahun 2017 ke tahun 2018. Pola kontradiktif ini akan menjadi masalah berkelanjutan dan bahkan bisa menjadi bencana mengerikan apabila tidak ada penanganan tepat sasaran. Kebijakan pemerintah sampai saat ini sudah ada, bahkan beberapa program sudah dicanangkan untuk mengatasi permasalahan mengenai sampah. Meskipun demikian, kondisi di lapangan ternyata tidak sesuai dengan harapan dan rencana pemerintah. Penelitian deskriptif ini menggunakan metode statitik untuk pengolahan data sekunder dan primer kemudian dianalisis berdasarkan pemodelan sistem dinamis. Hasil penelitian menunjukkan bahwa sistem pengelolaan sampah Yogyakarta belum cukup baik. Beberapa faktor yang mempengaruhi diantaranya kebijakan pemerintah belum diketahui secara menyeluruh, budaya peduli sampah dan kesadaran masyarakat masih rendah, serta fasilitas TPA belum memadai.</p><p> </p><strong>Kata kunci: Kesadaran Publik, Pengelolaan sampah, Regulasi, Tempat pembuangan akhir, Sistem Dinamik.</strong>
MODAL SOSIAL DALAM REVITALISASI KEARIFAN LOKAL (STUDI KASUS DESA WISATA KANDRI KECAMATAN GUNUNG PATI KOTA SEMARANG)
Authors: Jannati Syifa Ayyada , Ramadhan Dani , Pertiwi Cindy Nadya Dewi 
Published: August 2020

<p><em>Cities with various activities have a rapid change in every part of them. This change slowly began to threaten the value of local wisdom in society. It getting worst by globalization that will change the value of society and make them individualistic in this digital era. The revitalization for original culture through make a tourist village that will be the place for development local wisdom which is getting fade between village society in this globalization era is the right thought to solve this problem. The one of tourist village that elevate local wisdom is Kandri Tourist Village. Qualitative method has been selected by researchers to get data through interview an obsevation in research location. Social capital theory used by researches is the theory that was coined by Putnam</em><em>.</em><em> The goal of this research to give the knowledge to reader that tourist village notonly empowering society, but tourist village can elevate local wisdom that left out by this generation. The result in the process to realize culture revitalization and empowering other, have the different caracter is must that is local wisdom and have a leader as the developer to develop Kandri tourist village.</em><em></em></p><p><strong> </strong></p><p><strong><em>Keywords:</em></strong><strong> <em>Tourist Village, Local Wisdom, Social Capital. </em></strong><strong><em></em></strong></p><p><strong><em> </em></strong></p><p><strong>Abstrak</strong></p><p>Kota dengan berbagai hiruk pikuk yang ada di dalamnya mengalami perubahan pesat. Perkembangan ini secara perlahan mulai mengancam nilai kearifan lokal yang ada di masyarakat. Kondisi seperti ini diperparah dengan munculnya serbuan globalisasi yang semakin hari mulai mengubah tatanan masyarakat yang lebih individualis di era digital seperti sekarang ini. Dalam upaya untuk merevitalisasi budaya luhur yang telah ada, salah satu cara yang tepat dengan menggunakan desa wisata sebagai wadah guna merevitalisasi kearifan yang mulai luntur di masyarakat. Salah satu desa wisata yang mengangkat kearifan lokal yaitu Desa Wisata Kandri. Penelitian menggunakan metode kualitatif dengan pengambilan data menggunakan wawancara dan observasi. Teori modal sosial yang digunakan adalah teori yang dicetuskan oleh Putnam. Tujuan penelitian ini digunakan untuk memberikan pemahaman bahwa dengan adanya Desa Wisata Kandri tidak hanya memberikan pemberdayaan tetapi ikut merevitalisasi kearifan lokal yang mulai ditinggal generasi sekarang. Hasil penelitian menunjukkan dalam mewujudkan revitalisasi budaya dan pemberdayaan harus memiliki karakter yang membedakan yaitu kearifan lokal serta memiliki pemimpin sebagai pelaksana segala wujud pengembangan Desa Wisata Kandri.</p><p> </p><p><strong>Kata kunci : Desa Wisata, Kearifan Lokal, Modal Sosial</strong><strong>.</strong><strong></strong></p>
Assessing subsidence of Mexico City from InSAR and LandSat ETM+ with CGPS and SVM
Authors: Poreh Davod , Pirasteh Saied , Cabral-Cano Enrique 
Published: August 2020

Abstract
This study presents an enhanced analysis of the subsidence rates and their effects on Mexico City. As a result of excess water withdrawal, Mexico City is experiencing subsidence. To analyze this subsidence of Mexico City, we integrated and analyzed Interferometric Synthetic Aperture Radar (InSAR), Continuous Global Positioning Systems (CGPS), and optical remote sensing data. This study utilized 52 ENVISAT-ASAR, nine GPS stations, and one Landsat ETM+ image from the Mexico City area to gather a better understanding of the subsidence rates and its effects on Mexico City’s community. The finding of this study reveals a high amount of correlation (up to 0.98) between two independent geodetic methods. We also implemented the Support Vector Machine (SVM) analysis method based on Landsat ETM+ image to classify Mexico City’s population density. We used SVM to compare Persistent Scatterer Interferometry (PSI) subsidence rates with the buildings’ distribution densities. This integrated study shows that the fastest subsidence zone (i.e. areas greater than 100 mm/yr), which falls into the above-mentioned temporal baseline, occurs in the areas of high and moderate building distribution density.
How Different Health Literacy Dimensions Influences Health Status and Well-being among Men and Women: The Mediating Role of Health Behaviors
Authors: Zhang Fan , Or Peggy Pui-Lai , Chung Joanne Wai-Yee 
Published: August 2020

Abstract
Background. Health literacy, the ability to access, understand, evaluate, and apply health information, was found to contribute to positive health outcomes, possibly via promoting healthy behaviors. However, the specific pathways linking different health literacy skills to health and well-being has remained unclear. Methods. A cross-sectional survey with structural questionnaires was administered among 2236 community-based adults in Hong Kong (mean age = 46.10 ±19.05). Health literacy was measured by HLS-Asian-47. Participants' health behavior, physical conditions, and subjective well-being were reported.Results. With structural modeling path analysis, health literacy in finding and understanding information showed a direct effect on enhancing physical health. While applying information capacity had an indirect positive effect via promoting health behaviors, which was moderated by sex. Only among women, this indirect effect predicting fewer physical symptoms and better well-being was significant.Conclusions. Although similar patterns were found in physical condition and well-being, distinct direct and indirect pathways were found of different health literacy dimensions for men and women. Based on the findings, by targeting specific health literacy skills, education programs should be developed to enhance women’s health knowledge, and men's application of the knowledge in healthy lifestyle.
Labial Gingival Thickness Assessment at Mandibular Incisors of Orthodontic Patients With Ultrasound and Cone-Beam Ct. A Cross-Sectional Study
Authors: Kloukos Dimitrios , Kakali Lydia , Koukos George , Sculean Anton , Stavropoulos Andreas , Katsaros Christos 
Published: August 2020

Abstract
Background: Quantitative and qualitative analyses of several periodontal parameters play an important role in several dental procedures. Aim of the current study was to assess gingival thickness (GT) at mandibular incisors of orthodontic patients with two methods and determine how these methods are compared to each other when assessing periodontal anatomy through soft tissue thickness.Methods: The sample consisted of 40 consecutive adult orthodontic patients. GT was measured at both central mandibular incisors, mid-facially on the buccal aspect, 2mm apically to the free gingival margin with two methods: a) clinically with an Ultrasound device (USD) and b) radiographically with Cone Beam Computed Tomography (CBCT). Results: CBCT measurements were consistently higher than USD measurements, with the difference ranging from 0.13 mm to 0.21 mm. No difference was noted between the repeated CBCT measurements at the right central incisor (Bias= 0.05 mm; 95% CI= -0.01, 0.11, p=0.104). Although the respective results for the left incisor indicated, statistically, that the measurements were not exactly replicated, the magnitude of the point estimate was small and not clinically significant (Bias= 0.06 mm; 95% CI= 0.01, 0.11, p=0.014). Small differences between CBCT measurements made by the 2 examiners at the left central incisor (bias= 0.06 mm, 95% CI= 0.01, 0.11, p=0.014) were detected. However, this difference was minor, and again, not clinically significant. The respective analysis on the right incisor showed no significant difference (bias= 0.05 mm, 95% CI= -0.01, 0.11, p=0.246). Conclusions: In the present study GT was assessed clinically with in-situ measurements and radiographically after computer-aided appraisal. Based on the reproducibility, CBCT imaging proved to be at least as reliable as the ultrasound determination, but yielded higher values than the USD measurements.
Sexual Coercion at sexual debut and associated factors among Young Females in rural areas of Boset District, Eastern Ethiopia: A Mixed Method Study
Authors: Abeya Sileshi Garoma 
Published: August 2020

Abstract
Background

The sexual behavior and experience of young people in developing countries have considerable attention. Despite growing recognition of the problem, relatively little is known about the issue of coercive sex in rural settings in developing countries including Ethiopia.
Objectives

Assess the prevalence and associated factors of sexual coercion at sexual debut among young females in rural areas of Boset district, Oromia Region, Eastern Ethiopia.
Methods

Cross-sectional community based study was conducted using both qualitative and quantitative data collection methods. A sample of 632 young females aged 10–24 years was taken from six rural Kebeles by systematic random sampling procedure for quantitative and data were collected using a pre-tested structured questionnaire. The collected data were analyzed using SPSS version 23. Principally Binary Logistic regression model was fitted. Moreover, eight focus group discussions targeting different groups were held and analyzed thematically.
Results

The prevalence of sexual coercion at sexual debut was 36.5% among sexually active respondents. Married young female (COR, 0.39; 95%CI: 0.21,0.71), living alone (away from their parents (AOR, 5.07; 95%CI: 1.07,24.01), age (AOR, 0.19; 95%CI: 0. 064, 0.544), alcohol consumption (AOR, 2.44; 95%CI: 1.17, 5.08) and Khat chewing (AOR, 8.30; 95%CI: 1.892, 36.378) were factors predicting the likelihood of having sexual coercion at sexual debut.
Conclusion

Sexual coercion at sexual debut is a major public health problem among young females in the study community. The emerging program interventions need to take this problem into consideration.
Cell-free long non-coding RNA-H19 and miRNA-29a, miRNA-29b expression in Type 2 Diabetes Mellitus patients.
Authors: Alfaifi Mohammed , Verma Amit Kumar , Alshahrani Mohammed Yahya , Joshi Prakash C , Alkhathami Ali Gaithan , Ahmad Irfan , Hakami Abdulrahim Refdan , Beg Mirza Masroor Ali 
Published: August 2020

Abstract
Background: Type 2 diabetes mellitus [T2DM] has been one of the common diseases and characterized by increased blood glucose levels. T2DM participates in several organ damages as well revealed that cell-free non-coding RNAs and microRNAs (miRNAs) have been demonstrated to serve as important diagnostic/prognostic biomarkers in the pathophysiology of diabetes.Materials/Methods: The present study included clinically confirmed untreated newly diagnosed 200 cases of T2DM and 200 healthy subjects. Blood samples collected in fluoride vials were used to check blood glucose for fasting and after 2 hours of breakfast (postprandial), blood samples collected in EDTA vials used for the Hba1c level.Blood samples from all the participants were collected in plain vials used for cell-free total RNA extraction. Total extracted RNA was quantified and 100ng was used to synthesized the cDNA for cell-free lncRNA H19, miRNA-29a, and miRNA-29b expression using specific primers/ probes using quantitative real-time PCR method. Serum Biochemical parameters were analyzed after collection of the sample to observe the changes among T2DM cases and healthy controls. Subjective data were recorded to evaluate the association with lncRNA H19, miRNA-29a, and miRNA-29b expression among T2DM cases. Results: It was observed that type 2 diabetic patients had decreased [0.59 fold] lncRNA H19 expression while increased miRNA-29a [5.62 fold] and miRNA-29b [5.58 fold] expression. Decreased expression of lncRNA H19 was observed to be associated with gender [p=0.004], hypertension [p<0.0001], weight loss [p=0.02] and fatigue [p=0.02]. Increased miRNA29a expression was linked with hypertension [p<0.0001], alcoholism [p=0.04], and smoking [p<0.0001] as well as miRNA-29b expression was associated with hypertension [p=0.0001], weight loss [p=0.002], smoking [p=0.0002], alcoholism [p<0.0001]. Low [<1 fold] and high [>1 fold] expression of lncRNA H19 expression was linked with miRNA-29a [p=0.005] and miRNA-29b [p<0.0001] expression. lncRNA H19 expression showed negative correlation with miRNA-29a expression [r= -27, p<0.0001] and miRNA-29b [r= -47, p<0.0001]. Conclusion: The present study concluded that lower lncRNA H19 expression, and increased miRNA-29b, miRNA-29b expression associated with the severity of T2DM patients. Decreased lncRNA H19 expression, and increased miRNA-29b, miRNA-29b expression observed to be interrelated with clinicopathological findings of T2DM patients could involve in pathogenesis disease.
NMFNA: a non-negative matrix factorization network analysis method for identifying communities and characteristic genes from multi-type pancreatic cancer data
Authors: Ding Qian , Sun Yan , Shang Junliang , Li Feng , Zhang Yuanyuan , Liu Jin-Xing 
Published: August 2020

Abstract
Background: Pancreatic cancer (PC) is a common type of digestive system disease. Comprehensive analysis of multiple types of PC genetic data plays a crucial role in understanding its potential biological mechanisms. Currently, Non-negative Matrix Factorization (NMF) based methods are widely used for data analysis. Nevertheless, it is a challenge for them to integrate and decompose multiple types of data simultaneously.Results: In this paper, a Non-negative Matrix Factorization Network Analysis method, NMFNA, is proposed, which introduces a graph regularized constraint to NMF, for identifying communities and characteristic genes from multi-type PC data. Firstly, three PC networks, i.e., methylation network (ME), copy number variation network (CNV), and the bipartite network between them, are constructed by both ME and CNV data of PC downloaded from the TCGA database, using the Pearson Correlation Coefficient. Then, the NMFNA is proposed to detect core communities and characteristic genes from these three PC networks effectively due to its introduced graph regularized constraint, which is the highlight of NMFNA. Finally, both gene ontology enrichment analysis and pathway enrichment analysis are performed to deeply understand biological functions of detected core communities.Conclusions: Experimental results demonstrated that the NMFNA facilitates the integration and decomposition of multiple types of PC data simultaneously and can serve as an alternative method for detecting communities and characteristic genes from multiple genetic networks. The data and demo codes of NMFNA are available online at https://github.com/CDMB-lab/NMFNA.
Morphology, morphogenesis and phylogeny of the new soil ciliate, Bistichella granulifera n. sp. (Protista, Ciliophora)
Authors: Lyu Zhao , Li Jingbao , Wang Yurui , Ma Jiyang , Shao Chen 
Published: August 2020

Abstract
Background: Hypotrichous ciliates are showing extremely morphological diverse and complicated morphogenesis. However, many hypotrichs are still unknown/poorly-known and need to be explored. Recently, Foissner (2016) reassigned the species in Bistichella and Parabistichella. Due to lack of morphological and morphogenetic information, some problems were overlooked. In present work, a new species, Bistichella granulifera n. sp., was found in northern China. Based on its infraciliature, ontogenesis analyses and phylogenetic study, the phylogenetic position of Bistichella was discussed.Results: Bistichella granulifera n. sp. was characterized by having elongated oval body, two macronuclear nodules, cortical granules present, three frontal and three or four buccal cirri, three frontal rows with seven to ten cirri, usually two frontoventral rows with the left one usually terminates at 90% down length of body and no breaks in the right one. The main morphogenetic features of the novel species were as follows: (1) the posterior part of the old adoral membranelles is renewed; (2) frontoventral-transverse cirral anlagen III to V each form a frontal row, and anlagen VI to n each produce a frontoventral row; (3) both marginal rows and dorsal kineties develop intrakinetally; (4) the macronuclear nodules fuse to form a single mass. The gene sequence of Bistichella was investigated for the first time. Phylogenetic analyses based on the SSU rDNA sequences showed that the Bistichella groups with the non-dorsomarginalian hypotrichs.Conclusions: Morphology, morphogenesis and phylogenetic position of Bistichella granulifera n. sp., was investigated. Each frontoventral row originates from one anlage and only three bipolar dorsal kineties are present in the new species, which means it should belong to non-Dorsomarginalia rather than Amphisiellidae. Even though Bistichella has a close relationship with amphisiellids, due to the limited gene sequence, the phylogenetic position of Bistichella needs more data to be fully understood.