bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural insights into the tropomodulin assembly at the pointed ends of actin filaments
Authors: Tolkatchev Dmitri , Kuruba Balaganesh , Smith Garry E. , Swain Kyle D. , Smith Kaitlin A. , Moroz Natalia , Williams Trenton J. , Kostyukova Alla S. 
Published: November 2020

AbstractTropomodulins are a family of important regulators of actin dynamics at the pointed ends of actin filaments. Four isoforms of tropomodulin, Tmod1‐Tmod4, are expressed in vertebrates. Binding of tropomodulin to the pointed end is dependent on tropomyosin, an actin binding protein that itself is represented in mammals by up to 40 isoforms. The understanding of the regulatory role of the tropomodulin/tropomyosin molecular diversity has been limited due to the lack of a three‐dimensional structure of the tropomodulin/tropomyosin complex. In this study, we mapped tropomyosin residues interacting with two tropomyosin‐binding sites of tropomodulin and generated a three‐dimensional model of the tropomodulin/tropomyosin complex for each of these sites. The models were refined by molecular dynamics simulations and validated via building a self‐consistent three‐dimensional model of tropomodulin assembly at the pointed end. The model of the pointed‐end Tmod assembly offers new insights in how Tmod binding ensures tight control over the pointed end dynamics.
NFPA 652: The gap between industry's understanding and compliance
Authors: Ebadat Vahid , Cartwright Paul 
Published: November 2020

AbstractThe requirements of NFPA 652 Standard regarding Dust Hazard Analysis on the Fundamentals of Combustible Dust had to be fully implemented in 2020. In this article, we present the results of a survey that tested how well those with responsibility for NFPA 652 compliance have understood its requirements. We find that although there is a good level of understanding about what is required there are never‐the‐less a number of areas where the standard has been misunderstood.
UAV thermal image detects genetic trait differences among populations and genotypes of Fremont cottonwood (Populus fremontii, Salicaceae)
Authors: Sankey Temuulen , Hultine Kevin , Blasini Davis , Koepke Dan , Bransky Nathaniel , Grady Kevin , Cooper Hillary , Gehring Catherine , Allan Gerard 
Published: November 2020

AbstractMany plants are becoming increasingly maladapted to their environments due to changing climate and environmental conditions. It is, therefore, important to quantitatively evaluate what species, populations, and genotypes will survive in projected climate change scenarios and the implications this can have for associated biodiversity. We evaluate unmanned aerial vehicle (UAV)‐based high‐resolution thermal images for differentiating populations and genotypes in Fremont cottonwood (Populus fremontii S. Wats.), a foundation tree species that supports high levels of biodiversity and associated processes in riparian ecosystems. Specifically, we compare UAV thermal image‐derived tree canopy temperatures among 16 different populations and 10 replicated genotypes within two of the populations of Fremont cottonwood trees sourced from a broad environmental gradient and growing together in a common garden in central Arizona, USA. The UAV image‐derived tree canopy temperatures ranged 30°C–42°C resulting in a high overall accuracy of 85% in tree canopy classification. Our results indicate that the UAV thermal image‐derived mean tree canopy temperatures were significantly different among most of the 16 populations (P < 0.001). Within a warm‐adapted Sonoran Desert population and a cooler High Plateau population, the UAV thermal image‐derived tree canopy temperatures were also significantly different among many genotypes (P < 0.001). Furthermore, the UAV thermal image‐derived tree canopy temperatures were significantly correlated with tree canopy cover (R2 = 0.73; P‐value < 0.001) and varied with locations across the garden. Our findings have important implications for characterizing intraspecific genetic diversity in long‐lived forest trees like Fremont cottonwood and inferences for understanding ecosystem processes and guiding restoration efforts. We suggest that UAV thermal images can be used to rapidly scale laboratory‐ and plot‐based genetics research up to the landscape level. Ecological restoration efforts informed by projected climate scenarios can benefit from the UAV‐based genetics findings to identify future climate‐adapted populations and genotypes for potential propagation sources.
Soil gypsum determination
Authors: Herrero J. , Artieda O. , Weindorf D.C. 
Published: November 2020

AbstractThe methods for gypsum content determination in soils are summarized and their applicability discussed. Special attention is given to the critical step of sample preparation, stressing the elimination of the oven heating at temperatures surpassing 40°C. Wet methods are unsuitable for soils rich in gypsum or containing other sulfates. Instead, oven‐based methods playing on the mass variations due to the release of constitutional water of gypsum are preferable. Under laboratory settings, we recommend two existing methods: one directly measuring the loss of mass on heating and the other exploiting the gypsum–bassanite phase change under controlled conditions. Both reflectance and X‐ray fluorescence (XRF) provide nondestructive methods for quick gypsum appraisal, and combining both methods increases the accuracy. The results are easily calibrated with gravimetric methods.
Social capital, social support and perceived stress in college students: The role of resilience and life satisfaction
Authors: Kalaitzaki Argyroula , Tsouvelas George , Koukouli Sofia 
Published: November 2020

AbstractThe study examined whether online and offline social capital and offline social support are associated with less perceived stress in 403 undergraduate Greek college students through the mediating role of resilience and life satisfaction. Gender differences were also explored. A path analysis explored the relationships among the study variables and multi‐group analysis explored gender differences. Perceived stress was predicted indirectly by offline social support and offline bonding social capital through resilience and life satisfaction and directly by online bonding. However, offline bonding was associated with reduced resilience and life satisfaction, whereas social support was associated with increased levels of both. Interestingly, whereas offline bonding was associated with reduced perceived stress through resilience for women, for men it occurred through life satisfaction, and it was primarily resilience for women and life satisfaction for men that predicted reduced perceived stress. It was concluded that different personal ties/relationships are associated with perceived stress through diversified pathways and the pathways are different for men and women. Offline social support between closely tied persons is positively associated and offline bonding is negatively associated with the inner resources for a person to cope with stress, whereas online bonding is beneficial in directly decreasing stress.
Microengineered Human Vein‐Chip Recreates Venous Valve Architecture and Its Contribution to Thrombosis
Authors: Rajeeva Pandian Navaneeth Krishna , Walther Brandon K , Suresh Rishi , Cooke John P , Jain Abhishek 
Published: November 2020

AbstractDeep vein thrombosis (DVT) and its consequences are lethal, but current models cannot completely dissect its determinants—endothelium, flow, and blood constituents—together called Virchow's triad. Most models for studying DVT forego assessment of venous valves that serve as the primary sites of DVT formation. Therefore, the knowledge of DVT formed at the venous cusps has remained obscure due to lack of experimental models. Here, organ‐on‐chip methodology is leveraged to create a Vein‐Chip platform integrating fully vascularized venous valves and its hemodynamic, as seen in vivo. These Vein‐Chips reveal that vascular endothelium of valve cusps adapts to the locally disturbed microenvironment by expressing a different phenotype from the regions of uniform flow. This spatial adaptation of endothelial function recreated on the in vitro Vein‐Chip platform is shown to protect the vein from thrombosis from disturbed flow in valves, but interestingly, cytokine stimulation reverses the effect and switches the valve endothelium to becoming prothrombotic. The platform eventually modulates the three factors of Virchow's triad and provides a systematic approach to investigate the determinants of fibrin and platelet dynamics of DVT. Therefore, this Vein‐Chip offers a new preclinical approach to study venous pathophysiology and show effects of antithrombotic drug treatment.
Non-vanishing zero-temperature normal density in holographic superfluids
Authors: Goutéraux Blaise , Mefford Eric 
Published: November 2020

AbstractThe low energy and finite temperature excitations of ad+ 1-dimensional system exhibiting superfluidity are well described by a hydrodynamic model with two fluid flows: a normal flow and a superfluid flow. In the vicinity of a quantum critical point, thermodynamics and transport in the system are expected to be controlled by the critical exponents and by the spectrum of irrelevant deformations away from the quantum critical point. Here, using gauge-gravity duality, we present the low temperature dependence of thermodynamic and charge transport coefficients at first order in the hydrodynamic derivative expansion in terms of the critical exponents. Special attention will be paid to the behavior of the charge density of the normal flow in systems with emergent infrared conformal and Lifshitz symmetries, parameterized by a Lifshitz dynamical exponentz >1. When 1≤ z < d+ 2, we recover (z= 1) and extend (z >1) previous results obtained by relativistic effective field theory techniques. Instead, whenz > d+ 2, we show that the normal charge density becomes non-vanishing at zero temperature. An extended appendix generalizes these results to systems that violate hyperscaling as well as systems with generalized photon masses. Our results clarify previous work in the holographic literature and have relevance to recent experimental measurements of the superfluid density on cuprate superconductors.
Understanding emergent teaching and learning practices: iPad integration in Polish school
Authors: Kopciewicz Lucyna , Bougsiaa Hussein 
Published: November 2020

AbstractThe appearance of tablet technology in the classroom is considered an obvious modernisation milestone. In the last few years school professionals in Poland have made large investments in digitalisation, especially through one to one model (1:1), using digital devices such as tablets. Researches on tablet technology integration in school classrooms convince that digital technologies are closely related to the discourse of educational change. What really changes when digital technology is used in the classroom? This is a driving question for the present study. This research contributes knowledge and new insights into learning and teaching practices in two classrooms in a Polish primary school that were observed over a longer perspective of three school semesters. The design of teaching and learning with tablet technology was explored using the didactical design framework. This perspective focuses on both teachers’ practices and students’ learning activities in the classroom and how tablet technology is integrated into teaching and learning practices. Although the research project was performed on a small scale, it can be defined as one that documents the changes to learning and teaching practices happening in the traditional educational culture of the school under analysis. These changes were identified through the data collected by means of classroom video ethnography (63 teaching hours of recording) and follow-up interviews (18) with classroom’s teachers. The analysis resulted in three distinct maps of emergent teaching and learning practices and a series of conflicts and tensions teachers experience in their everyday tablet-mediated teaching practices. The findings point out that tablet technology integration needs the alignment of the classroom pedagogy - technology relationships.
No Purification Ontology, No Quantum Paradoxes
Authors: D’Ariano Giacomo Mauro 
Published: November 2020

AbstractIt is almost universally believed that in quantum theory the two following statements hold: (1) all transformations are achieved by a unitary interaction followed by a von-Neumann measurement; (2) all mixed states are marginals of pure entangled states. I name this doctrine the dogma of purification ontology. The source of the dogma is the original von Neumann axiomatisation of the theory, which largely relies on the Schrődinger equation as a postulate, which holds in a nonrelativistic context, and whose operator version holds only in free quantum field theory, but no longer in the interacting theory. In the present paper I prove that both ontologies of unitarity and state-purity are unfalsifiable, even in principle, and therefore axiomatically spurious. I propose instead a minimal four-postulate axiomatisation: (1) associate a Hilbert space $${\mathcal {H}}_\text{A}$$

H
A

to each system$$\text{A}$$
A
; (2) compose two systems by the tensor product rule $${\mathcal {H}}_{\text{A}\text{B}}={\mathcal {H}}_\text{A}\otimes {\mathcal {H}}_\text{B}$$

H
AB

=

H
A

⊗

H
B

; (3) associate a transformation from system $$\text{A}$$
A
to $$\text{B}$$
B
to a quantum operation, i.e. to a completely positive trace-non-increasing map between the trace-class operators of $$\text{A}$$
A
and $$\text{B}$$
B
; (4) (Born rule) evaluate all joint probabilities through that of a special type of quantum operation: the state preparation. I then conclude that quantum paradoxes—such as the Schroedinger-cat’s, and, most relevantly, the information paradox—are originated only by the dogma of purification ontology, and they are no longer paradoxes of the theory in the minimal formulation. For the same reason, most interpretations of the theory (e.g. many-world, relational, Darwinism, transactional, von Neumann–Wigner, time-symmetric,...) interpret the same dogma, not the strict theory stripped of the spurious postulates.
Spectral clustering of combinatorial fullerene isomers based on their facet graph structure
Authors: Bille Artur , Buchstaber Victor , Spodarev Evgeny 
Published: November 2020

AbstractAfter Curl, Kroto and Smalley were awarded 1996 the Nobel Prize in chemistry, fullerenes have been subject of much research. One part of that research is the prediction of a fullerene’s stability using topological descriptors. It was mainly done by considering the distribution of the twelve pentagonal facets on its surface, calculations mostly were performed on all isomers ofC40,C60andC80. This paper suggests a novel method for the classification of combinatorial fullerene isomers using spectral graph theory. The classification presupposes an invariant scheme for the facets based on the Schlegel diagram. The main idea is to find clusters of isomers by analyzing their graph structure of hexagonal facets only. We also show that our classification scheme can serve as a formal stability criterion, which became evident from a comparison of our results with recent quantum chemical calculations (Sure et al. in Phys Chem Chem Phys 19:14296–14305, 2017). We apply our method to classify all isomers ofC60and give an example of two different cospectral isomers ofC44. Calculations are done with our own Python scripts available at (Bille et al. in Fullerene database and classification software,https://www.uni-ulm.de/mawi/mawi-stochastik/forschung/fullerene-database/, 2020). The only input for our algorithm is the vector of positions of pentagons in the facet spiral. These vectors and Schlegel diagrams are generated with the software package Fullerene (Schwerdtfeger et al. in J Comput Chem 34:1508–1526, 2013).
Challenges concerning test case specifications in automotive software testing: assessment of frequency and criticality
Authors: Juhnke Katharina , Tichy Matthias , Houdek Frank 
Published: November 2020

AbstractAutomotive test case specifications document test cases to be performed for a specific test object at a defined test level. They are a fundamental part of a structured automotive testing process, as required by the ISO 26262. The aim of our research is to identify challenges from a practitioner’s point of view that lead to poor quality of test case specifications and thus negatively impact time, cost, and probability of defect detection. We designed an exploratory case study to systematically identify challenges focusing on (C) creation, (P) processing, and (Q) quality assurance related aspects of test case specifications. We conducted 17 semi-structured interviews covering a German OEM as well as three of its automotive suppliers and analyzed them qualitatively. We investigated causes and consequences arising from the challenges. Additionally, we conducted a descriptive survey to assess frequency and criticality. The identified challenges were summarized in a taxonomy consisting of nine main categories: (1) availability and (2) content-related problems with input artifacts, problems related to (3) a lack of knowledge, (4) the test case description, (5) the test case specification content, (6) processes, (7) communication, (8) quality assurance, and (9) tools. The challenges were assessed by 26 internal and 10 external employees. Hence, we identified differences between these groups in terms of access to documents, incomplete requirements, scope of model series, process, and tool-related aspects. Overall, the study results underline the necessity of quality assurance measures for test case specifications. Based on the assessments, our research indicates a broad range of test case description related challenges that are promising candidates for improving test case specification quality.
Temporal Variation of Road Dust Load and Its Size Distribution—a Comparative Study of a Porous and a Dense Pavement
Authors: Lundberg Joacim , Gustafsson Mats , Janhäll Sara , Eriksson Olle , Blomqvist Göran , Erlingsson Sigurdur 
Published: November 2020

AbstractResuspension of road dust contributes to air quality issues with resulting health impacts. Limited studies imply that porous pavements can initially mitigate PM10 emissions by acting as a dust trap, but the abrasion wear generates road dust and thus accelerates the clogging processes. In addition, knowledge regarding the impact of pavement types on road dust load dynamics is limited. Road traffic noise can be mitigated using porous pavements, but the use of studded tyres increases the abrasion wear of the pavement as well as increasing the noise emission. Due to this durability problem, porous pavements are rarely used in the Nordic countries where, instead, dense pavements which are abrasion resistant are more common. Linköping municipality, in Sweden, constructed a porous pavement to mitigate road traffic noise. This led to the opportunity to investigate the temporal variation of the dust load dynamics and inherent size distributions over the winter and spring in comparison to those of an adjacent dense pavement. Results, when using the wet dust sampler (WDS) method, showed similar dust load dynamics for the dense and porous pavements. The results were also compared to previous studies using the same method on different dense pavements in Stockholm, Sweden. All locations showed a seasonal variation with higher dust loads during winter and early spring and declining loads towards summer. The size distributions were more complex for the wheel tracks at the porous pavement, having primarily properties of a mixture model compared to the simple size distributions for the dense pavement. On the other hand, the dust load and size distribution were more similar between the porous and dense pavements regarding loads and shapes, indicating a less pronounced but similar behaviour between the surfaces outside of the wheel tracks.
Capability Sensitive Design for Health and Wellbeing Technologies
Authors: Jacobs Naomi 
Published: November 2020

AbstractThis article presents the framework Capability Sensitive Design (CSD), which consists of merging the design methodology Value Sensitive Design (VSD) with Martha Nussbaum's capability theory. CSD aims to normatively assess technology design in general, and technology design for health and wellbeing in particular. Unique to CSD is its ability to account for human diversity and to counter (structural) injustices that manifest in technology design. The basic framework of CSD is demonstrated by applying it to the hypothetical design case of a therapy chatbot for mental health. By applying CSD to a design case, the merits of this new framework over the standard VSD approach become apparent. Also, the application demonstrates what a technology design would look like when attention is paid to capabilities right from the start of the design process.
Influencers on YouTube: a quantitative study on young people’s use and perception of videos about political and societal topics
Authors: Zimmermann Daniel , Noll Christian , Gräßer Lars , Hugger Kai-Uwe , Braun Lea Marie , Nowak Tine , Kaspar Kai 
Published: November 2020

AbstractThe roles of YouTube videos and YouTubers for getting information about political and societal topics are becoming gradually more important to young people. Quantitative research about young people’s use and perception of YouTube-videos and their potential effects on opinion formation is sparse though. This cross-sectional quantitative study addresses this empirical gap. We examined young people’s analytic-critical evaluations of YouTubers and their videos about political and societal topics (YTPS-videos), and how these are affected by the young people’s age and gender. We analysed questionnaire data of 562 participants and divided them into three different age groups. Overall, the participants reported a moderate watching frequency of YTPS-videos. They also rated YTPS-videos as moderately credible and considered specific characteristics of YTPS-videos and their producers as being moderately indicative for fake news. When comparing to traditional TV news, YTPS-videos were perceived as more entertaining, emotional, funny, exciting, modern, and motivating but also as more subjective and manipulating. Regarding YouTubers, the participants ascribed them an important role model function, but criticised them for handling it rather irresponsibly. Concerning opinion formation processes, the participants reported of a rather unimportant role of YTPS-videos for their learning about political and societal topics. They also perceived themselves as less influenceable than other peers and younger people. Still, they prefer talking with friends instead of teachers about YTPS-videos. Age and gender also had effects on various scales. These results deliver essential data for future research and educational measures and opened up unexplored areas in this research field.
How to become more grateful? The mediating role of resilience between empathy and gratitude
Authors: Lasota Agnieszka , Tomaszek Katarzyna , Bosacki Sandra 
Published: November 2020

AbstractThe current study examined the relationship between empathy, resilience, and gratitude. Specifically, the study investigated the potential mediating role of resilience between empathy and gratitude. The study involved 214 participants who completed the Gratitude Resentment and Appreciation Test-Revised (GRAT-R), the Questionnaire of Cognitive and Affective Empathy (QCAE), and the Resilience Measurement Scale (SPP-25). The results showed significant positive correlations among resilience, empathy, and gratitude. Multiple regression analysis confirmed that resilience, gender, and affective empathy were direct predictors of the level of gratitude. Structural equation modeling (SEM) analysis supported the hypothesis that resilience played a mediating role between empathy and gratitude. Implications for research and the promotion of positive psychology programs for adults are discussed.