bluuebunny/crossref_metadata_2025_split huggingface dataset:
INFLUENCE OF RESISTIN ON THE COURSE OF ISCHEMIC HEART DISEASE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Authors: Teplyakov A. T. , Akhmedov Sh. D. , Suslova T. Ye. , Andriyanova А. V. , Kuznetsova A. V. , Protopopova N. V. , Kalyuzhin V. V. , Nasanova O. N. 
Published: June 2020

Relevance. Through dermal coronary intravascular revascularization by means of stenting is an effective method of treatment CHD patients with the type 2 diabets. At the same time frequency of stents restenosing for this special cohort of patients is fluctuating from 12 by 40 %.Objective. To study prognostic significance of the new biomarker of intravascular inflammation of resisin in blood of CHD patients with DM 2 who suffered from stenting. Material and methods. In the study 60 patients (48 men and 12 women, in the middle age 60.9 years) with CHD and DM2 are included. The patients were divided into two groups: Patients with positive progress of comorbide pathology belonged to the first group (n = 30); in the second group (n =3 0) patients with unfavorable progress of cardiac vessel pathology were included. The further observation was carried during 12 months. Content of all the patients in blood of resistin with help of enzyme immunoassay analysis was determined, as well as lipid blood serum mixture and additional metabolic risk factors. By the indications control a coronary angiography was conducted. Restenosis of coronary arteries was counted as the narrowing of a coronal artery lumen of ≥70% in the place of an intervention.The result. Unfavorable flow, including restenosis of coronary arteries was revealed in 30 cases (50%). ROC-analysis showed great predictive significance of resistin – (area under a curve >5/35, Sensitivity 86.2, Specificit 70.0) in development of constrictive coronary atherosclerosis restenosis of coronary arteries after their stenosis.The conclusion. The study of resistin level in DM patients blood for the valuation of the disease prognosis and optimization of the tactics for choice of coronary pathology treatment seems expedient and informative.
Vers une révision des recommandations d’apports en phosphore chez le ruminant
Authors: BRAVO D. , MESCHY F. 
Published: June 2020

Pour répondre aux impératifs environnementaux émergents, il est devenu nécessaire de considérer les recommandations d’apport en phosphore à la fois sous l’angle d’une connaissance plus fine des besoins des animaux et de la maîtrise des rejets polluants. Les paramètres les plus sensibles de l’approche factorielle, besoin d’entretien et efficacité de l’utilisation digestive du phosphore ou coefficient d’absorption réelle (CAR), ont été réexaminés par l’analyse quantitative d’une base de données bibliographiques et par de nouvelles données expérimentales. Le besoin d’entretien apparaît fortement dépendant du flux salivaire de phosphore et de ses facteurs de variation ; il est donc logique de l’estimer à partir de la matière sèche ingérée et non du poids vif des animaux. La prise en compte de l’excrétion fécale du phosphore d’origine microbienne devrait contribuer à l’avenir à mieux préciser le besoin d’entretien. Les CAR retenus jusqu’à présent pour le calcul des recommandations sont notablement inférieurs aux données expérimentales publiées ; des différences substantielles sont observées entre les CAR des différents aliments et certains facteurs d’explication ont pu être mis en évidence. Les systèmes futurs devront adopter des valeurs de CAR différentes selon les aliments ou au moins selon les familles d’aliments. La vitesse de libération du phosphore dans le rumen est très variable selon les matières premières, ce qui suggère des différences importantes de disponibilité du phosphore pour l’écosystème du rumen. Dans la perspective d’une réduction sensible de l’apport de phosphore aux ruminants, il deviendra nécessaire de vérifier l’impact de cette disponibilité sur l’efficacité des microorganismes du rumen.
Structure, physical and mechanical properties of bronze castings obtained by continuous and centrifugal casting
Authors: Marukovich E. I. , Kharkov V. A. , Sazonenko I. O. , Kukareko V. A. , Kushnerov A. V. 
Published: June 2020

The influence of crystallization conditions (continuous and centrifugal casting) of small-sized BrА1Fe4Ni4 bronze castings on the structure, phase composition, and hardness was studied. It was found by metallographic and X-ray diffraction methods that the castings consist of (α + γ')-eutectoid, α phase and AlCu, Al2Cu3 intermetallic compounds. The matrix phase in the alloy, crystallized by centrifugal casting, due to its higher alloying with Al atoms, has an increased value of the crystal lattice parameter, compared with the case of continuous casting. The hardness of the casting obtained by centrifugal casting increases compared with continuous casting, which is due to the formation of a more dispersed structure, as well as a large solid solution hardening of the matrix phase of the casting.
The experience of using calcium carbide for the deoxidation of steel to replace aluminum in the conditions of OJSC «BSW – Management company of the holding «BMC»
Authors: Grudnitsky О. M. 
Published: June 2020

The article deals with issues related to the use of calcium carbide in steelmaking, instead of secondary aluminum and other deoxidizing materials, in order to reduce the cost of deoxidizing steel and slag.It was assumed that reducing the content of aluminum in the metal of the reinforcing steel grade would improve its spillability, and by improving the spillability, the yield of usable metal would increase. It was also expected that as a result of the use of calcium carbide for deoxidizing the coating slag in the ladle, the degree of contamination of cord steel with non-metallic inclusions would decrease.During the tests, the optimal amount of additive material was determined. In General, as a result of the work carried out, it was found that calcium carbide can be used for deoxidation of slag and metal during extra-furnace steel processingThe methods of adding the material are described in detail. The results of this work are presented.
A Dual-Grid, Implicit, and Sequentially Coupled Geomechanics-and-Composition Model for Fractured Reservoir Simulation
Authors: Li Xin , Li Xiang , Zhang Dongxiao , Yu Rongze 
Published: June 2020

SummaryIn the development of fractured reservoirs, geomechanics is crucial because of the stress sensitivity of fractures. However, the complexities of both fracture geometry and fracture mechanics make it challenging to consider geomechanical effects thoroughly and efficiently in reservoir simulations. In this work, we present a coupled geomechanics and multiphase-multicomponent flow model for fractured reservoir simulations. It models the solid deformation using a poroelastic equation, and the solid deformation effects are incorporated into the flow model rigorously. The noticeable features of the proposed model are it uses a pseudocontinuum equivalence method to model the mechanical characteristics of fractures; the coupled geomechanics and flow equations are split and sequentially solved using the fixed-stress splitting strategy, which retains implicitness and exhibits good stability; and it simulates geomechanics and compositional flow, respectively, using a dual-grid system (i.e., the geomechanics grid and the reservoir-flow grid). Because of the separation of the geomechanics part and the flow part, the model is not difficult to implement based on an existing reservoir simulator. We validated the accuracy and stability of this model through several benchmark cases and highlighted the practicability with two large-scale cases. The case studies demonstrate that this model is capable of considering the key effects of geomechanics in fractured-reservoir simulation, including matrix compaction, fracture normal deformation, and shear dilation, as well as hydrocarbon phase behavior. The flexibility, efficiency, and comprehensiveness of this model enable a more realistic geocoupled reservoir simulation.
One year follow-up and mediation in Cognitive Behavioral Therapy and Acceptance and Commitment Therapy for adult depression
Authors: A-Tjak Jacqueline G.L. , Morina Nexhmedin , Topper Maurice , Emmelkamp Paul M.G. 
Published: June 2020

Abstract
Background Existing therapies for depression are effective, but many patients fail to recover or relapse. To improve care for patients, more research into the effectiveness and working mechanisms of treatments is needed. We examined the long-term efficacy of Cognitive Behavioral Therapy (CBT) and Acceptance and Commitment Therapy (ACT) for Major Depressive Disorder (MDD), testing the hypothesis that CBT outperforms ACT and that both therapies work through their designated mechanisms of change.Methods We conducted a randomized controlled trial with 82 patients suffering from MDD. Data were collected before, during and after treatment, and at 12-month follow-up, assessing symptoms of depression, quality of life, dysfunctional attitudes, decentering , and experiential avoidance.Results Patients in both conditions reported significant and large reductions of depressive symptoms (d = -1.26 to -1.60) and improvement in quality of life (d = 0.91 to -1.28) 12 months following treatment. Our findings indicated no significant differences between the two interventions. Dysfunctional attitudes and decentering mediated treatment effects of depressive symptoms in both CBT and ACT, whereas experiential avoidance mediated treatment effects in ACT only. Conclusions Our results indicate that CBT is not more effective in treating depression than ACT. Both treatments seem to work through changes in dysfunctional attitudes and decentering, even though the treatments differ substantially. Change in experiential avoidance as an underlying mechanism seems to be an ACT-specific process. Further research is needed to investigate whether ACT and CBT may work differently for different groups of patients with depression.Trial registration clinicaltrials.gov; NCT01517503. Registered 25 January 2012 - Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT01517503?term=NCT01517503&rank=1
Health TAPESTRY Ontario: Protocol for a Randomized Controlled Trial to Test Reproducibility and Implementation
Authors: Mangin Dee , Lamarche Larkin , Bomze Sivan , Borhan Sayem , Browne Tracy , Carr Tracey , Datta Julie , Dolovich Lisa , Howard Michelle , Marentette-Brown Sarah , Oliver Doug , Risdon Cathy , Talat Samina , Tarride Jean-Eric , Thebane Lehana , Valaitis Ruta , Price David 
Published: June 2020

Abstract
Background: Health TAPESTRY (Health Teams Advancing Patient Experience: STRengthening qualitY) aims to help people stay healthier for longer where they live by providing person-focused care through the integration of four key program components: 1) trained volunteers who visit clients in their homes, 2) an interprofessional primary health care team, 3) use of technology to collect and share information, and 4) improved connections to community health and social services. The initial randomized controlled trial of Health TAPESTRY found promising results in terms of health care use and patient outcomes, indicating a shift from reactive to preventive care. The trial was based on one clinical academic centre, thus limiting generalizability. The study objectives are: 1) to test reproducibility of the established effectiveness of Health TAPESTRY on physical activity and hospitalizations, 2) to test the feasibility of, and understand the contributing factors to, the implementation of Health TAPESTRY in six diverse communities across Ontario, Canada, and 3) to determine the value for money of implementing Health TAPESTRY.Methods: This planned study is a pragmatic parallel randomized controlled trial with a delayed intervention for control participants at six months. This trial will simultaneously assess effectiveness and implementation in a real world setting (Type II hybrid) in six diverse communities across Ontario. Participants 70 years of age and older will be randomized into the Health TAPESTRY intervention or the control group (usual care). Intervention clients will receive an individualized plan of care from an interprofessional care team. The plan will be based on a client’s goals and current health risks identified through volunteer visits. The study’s outcomes are mapped onto the RE-AIM framework, with levels of physical activity and number of hospitalizations as the co-primary outcomes. The main analysis will be a comparison at six months.Discussion: It is important to evaluate the effectiveness and implementation of Health TAPESTRY in multiple communities prior to scaling or widespread adoption.Trial registration: ClinicalTrials.gov: NCT03397836 (posted January 12, 2018).
Theoretically designed interventions for colorectal cancer prevention: A Case of the Health Belief Model
Authors: Rakhshanderou Sakineh , Maghsoudloo Maryam , Safari-Moradabadi Ali , Ghaffari Mohtasham 
Published: June 2020

Abstract
Background: According to the WHO, most chronic diseases, including cancer, can be prevented by identifying their risk factors such as unhealthy diet, smoking and physical inactivity. This research examined the effectiveness of a theory-based educational intervention on colorectal cancer-related preventive nutritional behaviors among a sample of organizational staff. Methods: In this interventional study, 110 employees of Shahid Beheshti University of Medical Sciences were randomly divided into two groups (intervention and control) with cluster sampling. The data gathering tool was a researcher-made questionnaire containing two parts of 10-dimensional information and health belief model constructs. The educational intervention was conducted for one month and in four sessions in the form of classroom lecture, pamphlet, educational text messages via mobile phones and educational pamphlets through the office automation system. Two groups were evaluated in two stages, pre-test and post-test. Data were analyzed using SPSS-18 software, analysis of Covariance (ANCOVA) and independent t-test (intergroup comparisons). Results: Two groups were evaluated for variables such as age, sex, education level and family history of colorectal cancer, and there was no significant difference between the two groups (P<0.05). After the two months since intervention, except for the mean score of perceived barriers, which was not significant after intervention, the mean scores of knowledge, perceived susceptibility, perceived severity, perceived benefits, perceived self-efficacy, behavioral intention, and preventive behaviors were significantly increased after the intervention in the intervention group compared to the control group (P> 0.05). Conclusion: Implementation of educational intervention based on health belief model was effective for the personnel, and can enhance the preventative nutritional behaviors related to colorectal cancer.
Inhibition of lipogenesis and induction of apoptosis by valproic acid in prostate cancer cells via the C/EBPα/SREBP-1 pathway
Authors: Pang Bo , Zhang Juanjuan , Yuan Jihong , Shi Yanan , Qiao Ling 
Published: June 2020

Abstract
Background: Lipid metabolism reprogramming is now accepted as a new hallmark of cancer. Hence, targeting the lipogenesis pathway may be a potential avenue for cancer treatment. Valproic acid (VPA) emerges as a promising drug for cancer therapy, however, the underlying mechanisms are not yet fully understood. This study aimed to investigate the effects and mechanisms of VPA on cell viability, lipogenesis, and apoptosis in human prostate cancer PC-3 cells. Methods: The effects of VPA on the viability and migration of PC-3 cells were investigated using MTT cell viability assay and wound-healing assay. Oil-Red O staining was used to examine lipid droplets, and DAPI staining assay and Annexin V-FITC and PI double-staining assay were used to measure the extent of cell apoptosis. Quantitative real-time PCR and Western blotting were used to determine the expression of lipogenesis and apoptosis genes. Statistical and analytical data were analyzed with SPSS 17.0 Software, and statistical significance was set to * P < 0.05, ** P < 0.01, and *** P < 0.001 levels. Results: The results showed that VPA significantly reduced lipid accumulation and induced apoptosis of PC-3 cells. Moreover, the expression of CCAAT/enhancer-binding protein α (C/EBPα), as well as sterol regulatory element binding protein 1 (SREBP-1) and its downstream effectors, including fatty acid synthase (FASN), acetyl CoA carboxylase 1 (ACC1), and antiapoptotic B cell lymphoma 2 (Bcl-2), markedly decreased in PC-3 cells after VPA administration. Mechanistically, the overexpression of C/EBPα rescued the levels of SREBP-1, FASN, ACC1, and Bcl-2, enhanced lipid accumulation and attenuated apoptosis of VPA-treated PC-3 cells. Conversely, knockdown of C/EBPα by siRNA further decreased lipid accumulation, enhanced apoptosis, and reduced the levels of SREBP-1, FASN, ACC1, and Bcl-2. In addition, SREBP-1a and 1c enhanced the expression of FASN and ACC1, but only SREBP-1a had a signiﬁcant eﬀect on Bcl-2 expression in VPA-treated PC-3 cells.Conclusions: On the whole, it is concluded that VPA significantly inhibits cell viability via decreasing lipogenesis and inducing apoptosis via the C/EBPα/SREBP-1 pathway in PC-3 cells. Therefore VPA which targets lipid metabolism and apoptosis is a promising candidate for prostate cancer chemotherapy.
Occurrence, risk factors and genotypes of Enterocytozoon bieneusi in dogs and cats in Guangzhou, southern China: high genotype diversity and zoonotic concern
Authors: Wang Haiyan , Lin Xuhui , Sun Yongxiang , Qi Nanshan , Lv Minna , Xiao Wenwan , Chen YuanCai , Xiang Ruiping , Sun mingfei , Zhang Longxian 
Published: June 2020

Abstract
Background: Enterocytozoon bieneusi, a common opportunistic fungal pathogen, has a wide range of hosts. Limited epidemiological data on E. bieneusi intestinal infections in companion animals (dogs and cats) in China exists. In this study, fecal samples (651 from dogs and 389 from cats) in Guangzhou city, Guangdong Province, China, were collected, and the ribosomal internal transcribed (ITS) spacer region from the DNA extracted from them was Polymerase Chain Reaction (PCR)-amplified and sequenced.Results: Based on the sequencing data, E. bieneusi was identified in the fecal samples collected from 149 (22.9%) and 79 (20.3%) dogs and cats. Of the factors investigated, poor living conditions appeared to be the major risk factor for contracting the pathogen. Eleven E. bieneusi genotypes, six known (PtEb IX, GD1, D, CD9, EbpC, I) and five novel (designated here as GD2– GD6), were found in dogs. Eight genotypes, six known (PtEb IX, GD1, D, CD9, EbpC, Type IV) and two novel (GD2 and GC1), were identified in cats. Genotype PtEb IX was most common in both dogs and cats, followed by genotype GD1.Conclusions: Although PtEb IX was the most common E. bieneusi genotype in dogs, this is the first report of this genotype dominating in cats. The same genotype distribution of the pathogen between the two different companion animals species in the same geographic area indicates that inter-species transmission is probable. The widespread existence of zoonotic E. bieneusi genotypes (D, EbpC, Type IV) in companion animals indicates that they are potential sources of environmental contamination and infections in humans.
Blood parasites in vectors reveal a united blackfly community in the upper canopy
Authors: Chakarov Nayden , Kampen Helge , Wiegmann Anja , Werner Doreen , Bensch Staffan 
Published: June 2020

Abstract
Background: The behaviour of blood-sucking arthropods is a crucial determinant of blood protozoan distribution and hence of host-parasite coevolution, but it is very challenging to study in the wild. The molecular identification of parasite lineages in vectors can be a useful key to understand the behaviour and transmission patterns realised by these vectors. Methods: In this study, we collected blackflies around nests of three raptor species in the upper forest canopy in central Europe and examined the presence of vertebrate DNA and haemosporidian parasites in them. We molecularly analysed 156 blackfly individuals, their vertebrate blood meals, and the haemosporidian parasite lineages they carried. Results: We identified nine species of Simulium blackflies, largely belonging to the subgenera Nevermannia and Eusimulium. Only 1% of the collected specimens was visibly engorged, and only 4% contained remains of host DNA. However, in 29% of the blackflies Leucocytozoon lineages were identified, which is evidence of a previous blood meal on an avian host. Based on the known vertebrate hosts of the recorded Leucocytozoon lineages, we can infer that large and/or abundant birds, such as thrushes, crows, pigeons, birds of prey, owls and tits are the main targets of ornithophilic blackflies in the canopy. Blackfly species contained similar proportions of host group-specific parasite lineages and thus do not appear to be associated with particular host groups. Conclusions: The Leucocytozoon clade infecting thrushes, crows, and pigeons present in most represented blackfly species suggests a lack of association between hosts and blackflies, which can increase the probability of host switches of blood parasites. However, the composition of the simuliid species differed between nests of common buzzards, goshawks and red kites. This segregation can be explained by coinciding habitat preferences between host and vector, and may lead to the fast speciation of Leucocytozoon parasites. Thus, subtle ecological preferences and lack of host preference of vectors in the canopy may enable both parasite diversification and host switches, and enforce a habitat-dependent evolution of avian malaria parasites and related haemosporidia.
Forty Years after Alma-Ata: How People Trust Primary Health Care?
Authors: Bazargani Homayoun Sadeghi , Saadati Mohammad , Tabrizi Jafar Sadegh , Farahbakhsh Mostafa , Golestani Mina 
Published: June 2020

Abstract
Background: Primary Health Care (PHC) was introduced as the first level of health services delivery after Alma-Ata declaration. However, after forty years, it needs to be more trustful to achieve its predefined objectives. Public trust in PHC is one of the neglected issues in the context. The aim of this study is to evaluate public trust in PHC in Iran.Methods: The present investigation is a household survey conducted in East Azerbaijan Province, Iran. Two-stage cluster sampling method with Probability Proportional to Size (PPS) approach was used. Totally, 1178 households were enrolled in the study. PHC trust questionnaire and Ultra-short version of Socio-Economic Status assessment questionnaire (SES-Iran) was used for data collection. Data were analyzed using STATA software (version 15) through descriptive statistics and linear regression. Results: The mean± SD age of the participants was 41.2±15.1 and most (53.7%) were female. Mean score of PHC trust was 56.9±24.7 (out of 100). It was significantly different between residents of Tabriz (the capital of province) and other cities in the province (p<0.001). Linear regression showed that younger age, gender, insurance type, being married, and households higher socio-economic status had a significant positive effect on PHC trust level with R2 = 0.14383.Conclusions: Public trust in PHC system in Iran needs to be improved. Individual variables had a small but key role in trust level. PHC trust cannot be only affected by individual's variables and experiences but also by health system and health providers' characteristics and public context in which PHC system exists. PHC trust level could be used as a public indicator in health systems especially in Low and Middle Income Countries (LMIC) to contribute in system strengthening policies at the national and international levels.