bluuebunny/crossref_metadata_2025_split huggingface dataset:
APOC3 rs2070667 Associates with Serum Triglyceride Profile and Hepatic Inflammation in Nonalcoholic Fatty Liver Disease
Authors: Xu Qing-Yang , Li Han , Cao Hai-Xia , Pan Qin , Fan Jian-Gao 
Published: November 2020

Single‐nucleotide polymorphisms (SNPs) of apolipoprotein C3 (APOC3) play important role in lipid metabolism, and dyslipidemia underlies nonalcoholic fatty liver disease (NAFLD). But the correlation of serum lipidomics, APOC3 SNPs, and NAFLD remains limited understood. Enrolling thirty‐four biopsy‐proven NAFLD patients from Tianjin, Shanghai, Fujian, we investigated their APOC3 genotype and serum lipid profile by DNA sequencing and ultraperformance liquid chromatography‐tandem mass spectrometry (UPLC‐MS/MS), respectively. Scoring of hepatocyte steatosis, ballooning, lobular inflammation, and liver fibrosis was then performed to reveal the role of lipidomics‐affecting APOC3 SNPs in NAFLD‐specific pathological alterations. Here, we reported that APOC3 SNPs (rs4225, rs4520, rs5128, rs2070666, and rs2070667) intimately correlated to serum lipidomics in NAFLD patients. A allele instead of G allele at rs2070667, which dominated the SNPs underlying lipidomic alteration, exhibited downregulatory effect on triacylglycerols (TGs: TG 54 : 7, TG 54 : 8, and TG 56 : 9) containing polyunsaturated fatty acid (PUFA). Moreover, subjects with low‐level PUFA‐containing TGs were predisposed to high‐grade lobular inflammation (TG 54 : 7, rho = −0.454 and P = 0.007; TG 54 : 8, rho = −0.411 and P =0.016; TG 56 : 9, rho = −0.481 and P = 0.004). The significant correlation of APOC3 rs2070667 and inflammation grading [G/G vs. G/A+A/A: 0.00 (0.00 and 1.00) vs. 1.50 (0.75 and 2.00), P = 0.022] further confirmed its pathological action on the basis of lipidomics‐impacting activity. These findings suggest an inhibitory effect of A allele at APOC3 rs2070667 on serum levels of PUFA‐containing TGs, which are associated with high‐grade lobular inflammation in NAFLD patients.
New records of the sponge-symbiotic shrimp genus Anchistioides from the Indo-West Pacific (Decapoda, Caridea)
Authors: Fransen Charles H. J. M. 
Published: November 2020

Abstract
The family Anchistioididae comprises a single genus Anchistioides with three species: A. compressus and A. willeyi from the tropical Indo-West Pacific, and A. antiguensis from the tropical West Atlantic. The two Indo-West Pacific species are known to be symbionts of sponges. Material collected in recent years throughout the Indo-West Pacific yielded range extensions as well as new host records. This material is herein described and their infraspecific morphological variation discussed.
Sicyonella liui sp. nov., a new sergestid shrimp (Decapoda, Dendrobranchiata) discovered from Madagascar
Authors: Chan Tin-Yam 
Published: November 2020

Abstract
A new species of the sergestid shrimp genus Sicyonella Borradaile, 1910 was discovered in a recent expedition to southern Madagascar. The presence of Sicyonella in Madagascar is also a new genus record for the country. The new species has the petasma and thelycum very different from the three known species of the genus, and is also unique in the basal part of the mesial antennular flagellum not being modified in males.
A new species of Stygiopontius (Copepoda, Siphonostomatoida, Dirivultidae) from a deep-sea cold seep in the South China Sea
Authors: Ma L. , Wang M.-X. , Li X.-Z. 
Published: November 2020

Abstract
A new species of the copepod genus Stygiopontius is described based on samples from a cold seep in northeastern South China Sea southwest to Taiwan, which were collected by the ROV Faxian with its mother vessel R/V Kexue in September 2017. The copepods were obtained by washing Shinkaia crosnieri Baba & Williams, 1998 (Decapoda: Munidopsidae) caught at a depth of 1124 m. The new species can be distinguished from its congeners by the combination of the following characteristics: caudal rami about 3.5 times as long as wide; basis of maxilliped with plumose seta, endopodal claw of maxilliped stout, with a row of fine spinules on inner margin; coxa of leg 1 with one inner seta; basis of leg 1 with stout spine exceeding to end of first endopodal segment; second endopodal segment of female leg 4 with pointed process; third exopodal segment of leg 4 with three outer spines. This is the first record of a Stygiopontius species from a cold seep.
Ruiyupotamon, a new genus and four new species of freshwater crabs from northwestern Yunnan, China (Decapoda, Brachyura, Potamidae)
Authors: Wang Pengfei , Zhang Zewei , Sun Hongying 
Published: November 2020

Abstract
A new genus Ruiyupotamon gen. nov. and four new species, R. banqiaopingense sp. nov., R. zhongjiangense sp. nov., R. jinjiangense sp. nov., and R. zhongyiense sp. nov. belonging to the subfamily Potamiscinae (Potamidae), collected from northwestern Yunnan Province, P.R. China, are described. Molecular phylogenetic data derived from both mitochondrial (16S), and nuclear (28S and ITS2) markers supports the establishment of the new genus and four new species.
Between the Superpowers
Authors: Uljas Sami , Landborg Anne , Müller Matthias 
Published: November 2020

Abstract
In early Coptic stories of saints and martyrs, demons are usually prototypical adversaries and side with the devil in his battle against Christ. However, it has been noted that in magical texts of a definitely Christian social origin, demons are sometimes invoked for assistance. Such sources might perhaps be dismissed as unrepresentative of the official theological position of the Alexandrian church, but, as is shown in the present paper, demons are occasionally portrayed as champions of Christ also in more ‘respectable’ texts such as hagiographies of the later 1st millennium AD. This is argued to show that the more nuanced analysis of demons does not represent an early folk undercurrent of Egyptian Christianity, but rather reflects an alternative theological view derived from the idea that God created good and evil for a reason.
Rufinus’ Bloody Pagan Tyrants
Authors: Hanaghan Michael P. 
Published: November 2020

Abstract
This article analyses how Rufinus alters and then extends Eusebius’ church history to draw a narrative continuum of pagan idolatry, tyranny and blood sacrifice across the fourth century. It begins with a taxonomy that illustrates the various ways that Rufinus’ text differs from Eusebius’ and then analyses how Rufinus enhances the levels of cruelty and bloody carnage in his Eusebian source, especially with regards to the tyrannical behaviour of the pagan emperors Maximinus, Maxentius, and Licinius. Lastly, it turns to Rufinus’ account of Eugenius’ uprising and the destruction of the temple of Serapis and shows how Rufinus’ repeated criticism of pagan imperial persecution acts to justify Theodosius’ actions.
Human Flourishing and History: A Religious Imaginary for the Anthropocene
Authors: Tirosh-Samuelson Hava 
Published: November 2020

Abstract
The Anthropocene denotes the impact of human activity on Earth systems, resulting in mass extinctions of plant and animal species, pollution of oceans, lakes and rivers, and altering of the atmosphere. The Anthropocene signifies the mass control of nature by humans, the erasure of boundaries between humanity and nature, and the threat to human existence by human-made technology. How can biological humans flourish, if their physical environment, the very condition of their existence, is destroyed? What does it mean to thrive as a human in an age when human-made machines threaten to make humanity obsolete? How does human flourishing relate to human history? This essay argues that the monotheistic traditions, and Judaism in particular, offer meaningful religious imaginaries for the Anthropocene because they envision human flourishing as embodied, ecological and historically grounded. In contrast to secular imaginaries, which either declare the “end of nature” or envision the obsolescence of biological humanity, the Judaic religious imaginary honors the interconnectedness and interdependence of all creatures, while recognizing human responsibility toward the well-being of the natural world. Viewing nature as divinely created, and, thus “enchanted” by the divine presence, the Judaic religious imaginary offers a vision of human flourishing based on the ethics of care and responsibility that enables humanity to respond and perhaps even prevent further ecological collapse.
<strong>A morphological and phylogenetic characterisation of <em>Inocybe similis</em> (Agaricales, Inocybaceae), a rare species described by Bresadola in 1905</strong>
Authors: DOVANA FRANCESCO , FERISIN GIULIANO , BIZIO ENRICO , BANDINI DITTE , OLARIAGA IBAI , ESTEVE-RAVENTÓS FERNANDO 
Published: November 2020

Inocybe similis, a very rare smooth-spored species originally described from Italy by Bresadola, is illustrated. Based on sequence generated from the type specimen, freshly collected specimens from five sites, Grado in north-east Italy, Tolmin in Slovenia, Forchach and Rieden in Austria and Füssen in Gemany could be asigned to I. similis and a more detailed description is provided here. The macro- and micromorphological features of I. similis suggest this species should be placed in Inocybe sect. Splendentes according to Singer´s classification. In contrast, our phylogenetic analyses support instead that I. similis belongs to Inocybe sect. Marginatae. From a morphological point of view, I. similis is close to I. vulpinella, but it is phylogenetically close to I. flavobrunnescens in sect. Marginatae.
Incidence of Complicated Appendicitis as a Metric of Health Care Delivery
Authors: Araim Fawaz , Shmelev Artem , Kowdley Gopal C. 
Published: November 2020

Background Complicated acute appendicitis (CAA) has been linked to extremes of age, racial and socioeconomic disparities, public insurance, and remote residency. CAA rate has been used from 2005 to 2018 as a health care quality metric, with the assumption that delay in treatment was a main cause of perforation. We studied factors that could contribute to CAA focusing on modifiable factors which could be altered as part of a health care delivery system. Materials and Methods All primary admissions for acute appendicitis (AA) from the 2010 Nationwide Inpatient Sample were linked to 2010 state-level physician density data. CAA was distinguished by codes for perforation, generalized peritonitis, or intra-abdominal abscess. A multivariable logistic regression model for CAA prediction was built. Results A total of 288 556 patients were admitted with AA and 86 272 (29.9%) had CAA. Independent factors, linked to CAA, included age outside the 10-39 range (odds ratio (OR) = 2.1-2.4 and all P < .001), male gender (OR = 1.2), malnutrition (OR = 6.2), diabetes mellitus (OR = 2.1), chronic anemias (OR = 1.9), nonprivate insurances (OR 1.2-1.5), nonmetropolitan patient’s residence (OR = 1.15), and Midwest region (OR = 1.2). Patient income and physician coverage were not significant factors after adjustment for all other covariates. Highest CAA fraction of 39.6% was noted in rural patients admitted to urban teaching facilities. Discussion Although provider coverage at the state level may seem adequate and not related to increased CAA rates, the distance patients traveled for their definitive surgical care correlated with higher rates of CAA. Adjusting physician distribution into nonurban settings closer to patients could decrease rates of CAA by diminishing time to definitive care.
Assessment of Factors Impacting Long-Term Utilization of Tracheoesophageal Speech Among Laryngectomees
Authors: Boyd Christopher , Houghton James , Harrold Logan , Bond Justin , Garnett James D. , Kraft Shannon 
Published: November 2020

Objective(s): To evaluate complication rate and abandonment rate after tracheoesophageal puncture and to assess factors associated with these outcome measures. Methods: Retrospective review of laryngectomy patients seen at a single academic institution between 1/1/2003 and 12/1/2018. Charts reviewed for demographics, medical comorbidities, tumor characteristics, surgical data, adjuvant treatment history, and complications related to laryngectomy or tracheoesophageal puncture. Complications were divided into minor and major. Results: A total of 293 laryngectomees met inclusion criteria. Of these, 69 patients (23.5%) underwent tracheoesophageal puncture. Average follow up was 64.6 months (SD 58.3). Overall laryngectomy complication rate was 43.3%. Overall tracheoesophageal puncture complication rate was 73.9%, with 39.1% of patients having major complications and 34.8% having minor complications only. Total abandonment rate for tracheoesophageal puncture was 34.8%. No associations were seen between tracheoesophageal puncture complication or abandonment rates based on age, gender, race, or insurance status. An increased rate of laryngectomy complications was seen after primary tracheoesophageal puncture (76.5% vs 41.3%, P = .005). Conclusion: Tracheoesophageal puncture outcomes were similar in patients with varied demographic, medical, and treatment backgrounds. When considering timing, our findings suggest that patients should be counseled on the possibility of increased complication risk after primary tracheoesophageal puncture. In those in whom the surgeon already has concerns about wound healing, it may be prudent to avoid primary tracheoesophageal puncture. The relatively high abandonment rate emphasizes the value of this measure of tracheoesophageal puncture outcome and highlights the need for appropriate patient counseling and prospective studies assessing the decision to abandon.
External Human–Machine Interfaces Can Be Misleading: An Examination of Trust Development and Misuse in a CAVE-Based Pedestrian Simulation Environment
Authors: Kaleefathullah Anees Ahamed , Merat Natasha , Lee Yee Mun , Eisma Yke Bauke , Madigan Ruth , Garcia Jorge , Winter Joost de 
Published: November 2020

Objective To investigate pedestrians’ misuse of an automated vehicle (AV) equipped with an external human–machine interface (eHMI). Misuse occurs when a pedestrian enters the road because of uncritically following the eHMI’s message. Background Human factors research indicates that automation misuse is a concern. However, there is no consensus regarding misuse of eHMIs. Methods Sixty participants each experienced 50 crossing trials in a Cave Automatic Virtual Environment (CAVE) simulator. The three independent variables were as follows: (1) behavior of the approaching AV (within-subject: yielding at 33 or 43 m distance, no yielding), (2) eHMI presence (within-subject: eHMI on upon yielding, off), and (3) eHMI onset timing (between-subjects: eHMI turned on 1 s before or 1 s after the vehicle started to decelerate). Two failure trials were included where the eHMI turned on, yet the AV did not yield. Dependent measures were the moment of entering the road and perceived risk, comprehension, and trust. Results Trust was higher with eHMI than without, and the −1 Group crossed earlier than the +1 Group. In the failure trials, perceived risk increased to high levels, whereas trust and comprehension decreased. Thirty-five percent of the participants in the −1 and +1 Groups walked onto the road when the eHMI failed for the first time, but there were no significant differences between the two groups. Conclusion eHMIs that provide anticipatory information stimulate early crossing. eHMIs may cause people to over-rely on the eHMI and under-rely on the vehicle-intrinsic cues. Application eHMI have adverse consequences, and education of eHMI capability is required.
Prevalence of depression, anxiety and stress in china during COVID-19 pandemic: A systematic review with meta-analysis
Authors: Bareeqa Syeda Beenish , Ahmed Syed Ijlal , Samar Syeda Sana , Yasin Waqas , Zehra Sani , Monese George M , Gouthro Robert V 
Published: November 2020

Background The novel coronavirus disease which is believed to have initially originated in Wuhan city of China at the end of 2019 was declared as pandemic by March 2020 by WHO. This pandemic significantly impacted the mental health of communities around the globe. This project draws data from available research to quantify COVID-19 mental health issues and its prevalence in China during the early period of the COVID-19 crisis. It is believed that this pooling of data will give fair estimate of the effects of the COVID-19 pandemic on mental health. Methods We conducted this study in accordance with PRISMA guidelines 2009. The protocol for this review is registered and published in PROSPERO (CRD42020182893). The databases used were Pubmed, Medline, Google scholar and Scopus. The studies were extracted according to pre-defined eligibility criteria and risk of bias assessment was conducted. The Meta-analysis was done using OpenMeta [analyst]. Results Total of 62382 participants in nineteen studies fulfilled the eligibility criteria. Stress was the most prevalent (48.1%) mental health consequence of Covid-19 pandemic, followed by depression (26.9%) and anxiety (21.8%). After performing subgroup analysis, prevalence of depression and anxiety in both females and frontline health care workers were high as compared to the prevalence in general Chinese population. Conclusion The prevalence of depression and anxiety is moderately high whereas pooled prevalence of stress was found to be very high in Chinese people during this Covid-19 crisis.
An evaluation of hard-shell venous reservoir integrated pressure relief valve pressure mitigation performance
Authors: Saczkowski Richard , Zulauf Fabio , Spada Saverio 
Published: November 2020

Introduction: Vacuum assisted venous drainage (VAVD) requires the sealing of the hard-shell venous reservoir, thereby creating circumstances where reservoir pressurization may occur. Manufacturers utilize integrated pressure relief valves (IPRV) to mitigate pressurization risk; however, accidents have been reported even with these devices. We have undertaken a performance evaluation of IPRV’s in a large number of hard-shell venous reservoirs. Methods: Reservoirs were sealed and gas insufflated while measuring reservoir internal pressure. Linear regression models were developed to depict the association between internal pressure and gas inflow rate. External secondary one-way valves (ESOV) were assessed for pressure mitigation performance. An assisted venous drainage survey was circulated to Canadian Clinical Perfusionists. Results: The reservoirs tested were adult ( n = 9, 64%) and pediatric ( n = 5, 36%) designs. Significant variability ( p < 0.001) in internal reservoir pressures (range: 0.04–161.41 mmHg) was observed across the titrated gas inflow rate (0.5–10.0 l/min). The regression models demonstrate excellent predictive performance (SE: 0.008–0.309). ESOV’s reduce the reservoir pressure below that of the IPRV; however, they cannot eliminate reservoir pressurization. The survey showed a majority (91%) of respondents use VAVD, and reservoir pressurization events occur regularly (18%). Conclusions: Significant variability among reservoir’s IPRV to mitigate reservoir pressurization exists. The predictive models are extremely accurate at estimating the internal pressure. ESOV performance limitations moderate their utility as a backup pressure mitigation technique. A significant number of reservoir pressurization events are occurring with the use of VAVD. As a result, standardized communication from manufacturers on the purpose and performance of IPRV is recommended in order to delineate the limitations of these devices.
Reasons for failure to perform interventional pain procedures in cancer patients: an analysis of pain clinic consultations
Authors: Kim Ki Wook , Kim Shin Hyung , Won Ji Yeon , Jang Hun , Park Sang Jun 
Published: November 2020

Background Interventional pain procedures (IPPs) may be necessary for some cancer patients when conservative treatment fails. However, many IPPs are often delayed or cancelled for cancer patients who are referred to the pain clinic. Methods We retrospectively analyzed the reasons for such cancellations to identify clinically avoidable causes of the delay in IPP. Results We enrolled 350 cancer patients who were referred to our pain clinic for an IPP between March 2016 and February 2018. There were 213 (60.9%) cases that were cancelled, among which 115 (54%) cases were potentially avoidable and 98 (46%) were unavoidable. The most common reasons for cancellation were patient-derived factors, which accounted for 85 (39.9%) cases. Patient refusal was a common reason for cancellation, with 33 (15.5%) cases attributed to this cause. The primary avoidable causes of cancellation were a recommendation that the patient continue with their current pharmacological pain treatment, conflict with another planned treatment, and pain characteristics that were not suitable for an IPP. Together, these accounted for 76.5% of all avoidable cancellations. Conclusions Comprehensive and accurate pain assessments before IPP may result in more favorable outcomes for the efficient use of medical resource and effective pain relief in cancer patients.
Retrospective survival analysis in patients with metastatic pancreatic ductal adenocarcinoma with insulin-treated type 2 diabetes mellitus
Authors: Pretta Andrea , Ziranu Pina , Puzzoni Marco , Lai Eleonora , Orsi Giulia , Liscia Nicole , Molinaro Eleonora , Mariani Stefano , Riggi Laura , Rovesti Giulia , Dubois Marco , Migliari Marco , Persano Mara , Saba Giorgio , Impera Valentino , Musio Francesca , Batzella Erich , Demurtas Laura , Pusceddu Valeria , Astara Giorgio , Faloppi Luca , Casadei Gardini Andrea , Andrikou Kalliopi , Cascinu Stefano , Scartozzi Mario 
Published: November 2020

Introduction: The association between pancreatic ductal adenocarcinoma (PDAC) and type 2 diabetes mellitus (DM2) has long been evaluated and the role of antidiabetic medications such as metformin has also been investigated. The objective of this study was to examine the association between insulin use and overall survival (OS) in patients with advanced PDAC and DM2. Methods: We retrospectively collected data from 164 patients, including an exploratory cohort of 96 patients from Medical Oncology Unit, University Hospital and University of Cagliari, Italy, and a validation cohort of 68 patients from Medical Oncology of Modena University Hospital. Patients had metastatic disease and received a first-line gemcitabine-based chemotherapy and, subsequently, a second-line fluoropyrimidines-based chemotherapy. We performed univariate analysis to evaluate correlation between long-term diabetes and overall survival. Then we performed multivariate analysis, adjusting for sex, metastatic sites, Eastern Cooperative Oncology Group Performance Status, Ca19.9 levels, N/L ratio, and lactate dehydrogenase levels at diagnosis, to confirm the independence of the variable. Results: In the exploratory cohort, DM2 was significantly associated with higher median OS at univariate analysis (16 vs 10 months; p = 0.004). This result was confirmed by validation cohort (11 months vs 6 months; p = 0.01). In multivariate analysis, insulin-treated patients compared with non diabetic patients showed a significantly increased survival of 4.6 months ( p = 0.03). Conclusions: Patients with insulin-treated metastatic PDAC showed better OS than non diabetic patients, as demonstrated by both cohorts. The correlation between OS and insulin-treated DM2 should be investigated further through a prospective clinical trial.