bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting HER2 in metastatic urothelial carcinoma: a contemporary review
Authors: Jang Albert , Ghimirey Nirmala , Kumar Hamsa L.S. , Mendiratta Prateek , Rao Santosh , Sheng Iris Y. , Barata Pedro C. , Garcia Jorge A. , Brown Jason R. 
Published: February 2025

Abstract
Metastatic urothelial carcinoma (mUC) is considered an incurable malignancy; however, patient outcomes are improving with the adoption of novel treatments. A significant portion of patients with UC have HER2 overexpression measured by immunohistochemistry (IHC) and/or fluorescence in situ hybridization (FISH) or HER2 genomic amplifications and/or mutations detected on next-generation sequencing, making HER2 an attractive therapeutic target. Several clinical trials have assessed the efficacy of HER2-targeted therapies in UC, and trastuzumab deruxtecan has recently been approved as a tumor-agnostic systemic therapy for metastatic solid tumors, including mUC, that are HER2-positive by IHC 3+ expression. Nonetheless, clinical trials of HER2-targeting therapies in mUC have used different assays for the measurement of HER2 positivity, which could affect results. This review summarizes past experiences and delves into the controversies and potential of HER2-targeting therapies, including antibodies, tyrosine kinase inhibitors, and antibody-drug conjugates, in mUC.
A systematic review of metakaolin-based alkali-activated and geopolymer concrete: A step toward green concrete
Authors: Qader Diyar N. , Jamil Ary Shehab , Bahrami Alireza , Ali Mujahid , Arunachalam Krishna Prakash 
Published: February 2025

Abstract
Expanding the world’s infrastructure drives up demand for building materials, particularly ordinary Portland cement (OPC) concrete, whose high carbon dioxide (CO2) emissions have a detrimental effect on the environment. To address this issue, researchers looked into employing alternative supplementary cementitious materials (SCMs), including metakaolin (MK), which is derived from calcined kaolin clay with pozzolanic properties, to partially or completely replace OPC in concrete. This review article examines the MK’s application in alkali-activated materials (AAMs) and OPC-based concrete. By interacting with calcium hydroxide, MK functions as a pozzolanic additive for OPC concrete, enhancing its mechanical qualities and durability. The use of MK as a source material in AAMs, a newly developed class of sustainable binders, is also covered in this article. The effects of different combinations of MK with additional SCMs, including fly ash (FA), ground granulated blast furnace slag (GGBFS), silica fume, and rice husk ash, on the characteristics of alkali-activated concrete both in its fresh and hardened states, are compiled. The majority of the articles considered in this study are from the past decade, while some relevant articles from 2014 and earlier are also taken into account. The results showed that adding MK to concrete in combination with FA or GGBFS has excellent synergistic effects on microstructural development, pozzolanic activity, and strength increases. In particular, the MK–FA mix demonstrated the most encouraging performance gains. Because of its large surface area, the use of nano-MK helped achieve a denser geopolymer structure and improve mechanical properties. The best curing temperatures for MK-based geopolymers to gain strength were found to be between 40 and 80°C for a total of 28 days. The review also pointed out that the compressive strength and geopolymerization process of MK-based geopolymers were enhanced by increasing the mass ratio of Na2SiO3 to NaOH and NaOH concentration. Nevertheless, geopolymerization was hampered by unnecessarily high alkali concentrations. Moreover, the compressive strength was increased by partially replacing MK with TiO2 or GGBFS. The synergistic effects of combining MK with other SCMs to improve concrete performance highlight the potential of MK-based solutions in lowering the environmental footprint of concrete buildings.
Effects of writing topic, first language background, and second language proficiency on ‘V that’ clauses in argumentative writing
Authors: Liu Yingying , Zhuang Jingyuan 
Published: February 2025

Abstract
With the growing use of corpora in second language (L2) research, examining the role of writing topics alongside first language (L1) background and L2 proficiency in shaping L2 usage has become increasingly important. This study contributes to this line of inquiry by using a learner corpus of 1,198 argumentative essays to explore how writing topics, in tandem with L1 background and L2 proficiency, influence the use of ‘V that’ clauses (e.g., I think that it is important…) among English as a Foreign Language (EFL) writers. The findings reveal significant effects of writing topic on the diversity and semantic distribution of ‘V that’, variations across L1 backgrounds, a decrease in frequency with higher L2 proficiency, and interaction effects among the three factors in all aspects of ‘V that’ usage. These findings highlight the importance of considering topic effects alongside L1 background and L2 proficiency in corpus-based L2 research, suggesting both theoretical and methodological implications.
Modell-basierte Entscheidungsunterstützung
Authors: Hertwig Michael 
Published: February 2025

Abstract
Insbesondere kleine und mittlere Unternehmen müssen sich trotz erforderlicher nachhaltiger Transformation wirtschaftlichen Zwängen unterordnen. Viele Nachhaltigkeitsmaßnahmen sind aufgrund längerfristiger Wirkung aus rein ökonomischer Sicht nicht immer rentabel. Eine erweiterte Analyse, die ökologische und soziale Dimensionen einbezieht, unterstützt eine vergleichende Diskussion verschiedener Maßnahmen. Dieser Beitrag skizziert einen Modell-basierten Ansatz, welcher auf das Unternehmen angepasst, die Simulation verschiedener Szenarien ermöglicht. Maßnahmenwirkungen unter besonderem Fokus auf die Fabrik und das urbane Umfeld lassen sich unter Berücksichtigung von Unsicherheiten bewerten. Beispielhaft wird das Potenzial für die strategische Unternehmensentwicklung verdeutlicht, was eine Umsetzung von Maßnahmen befördert.
Intelligente Energieoptimierung für nachhaltige Produktionssysteme
Authors: Schneider Alexander , Barth Martin , Müller Alexander , Reichenstein Tobias , Franke Jörg 
Published: February 2025

Abstract
In der industriellen Produktion ist die Steigerung der Energieeffizienz und die damit verbundene Reduktion von CO₂-Emissionen eine der zentrale Herausforderungen in Zeiten des Klimawandels. Besonders in energieintensiven Industrien ist eine optimierte Energienutzung unerlässlich. Der Beitrag untersucht Strategien zur nachhaltigen Energienutzung wie die Modellierung und Simulation von Energieverbräuchen zur Lastspitzenreduktion sowie die dynamische Anpassung der Produktionsphasen mithilfe maschinellen Lernens. Zudem werden Ansätze zur Auftragsplanung und -verteilung beschrieben, die durch Deep Reinforcement Learning optimiert werden, um Prozesse an erneuerbare Energien anzupassen. Digitale Zwillinge und detaillierte Energieüberwachung helfen, Ineffizienzen frühzeitig zu erkennen und zu korrigieren.
New quarries and workshops for long flint blade production in central Iberia (Brihuega, Guadalajara, Spain)
Authors: Triguero Ignacio , Luque Luis , Castillo-Jiménez Samuel , Rodríguez José Antonio Lozano , Aubry Thierry , Santos André , Magalhâes Carla , Ayuso Amador , Martínez-Sevilla Francisco 
Published: February 2025

Abstract
Two new sites, identified during a survey of the Tajuña River Valley, central Iberia, show evidence of both flint extraction and working, specifically for the production of long blades. These are an important addition to the limited number of such sites known in Eurasia.
Evaluation of Growth, Phenology, Yield and Weed Dynamics as Influenced by Integrated Weed Management in Black Rice Cultivars under Nagaland Condition
Authors: Chishi Hillel M. , Nongmaithem D. , Khoisnam Naveen , Bijayalakshmi Sorokhaibam , Tzudir Lanunola , Yadav Rekha , Malemnganbi T. 
Published: February 2025

Background: Black rice a special type of rice species known in multiple ways through its beneficial nutrients and health needs and are in need to be cultivated to its outmost potential. Cultivation of weed suppressible variety along with integrated weed management can be considered for high outcome of yield. Methods: A farm trial during kharif season of 2021 and 2022 was laid out in split plot design (SPD) on the experimental field of School of Agricultural Sciences (SAS), Nagaland University, Nagaland consisting of four integrated weed management in the main plot while sub-plot consisting of four cultivars respectively. Result: Grasses, sedges and broad-leaved weeds with a total of 11 species were identified and recorded dominant. Lowest depletion of nutrients by weed was observed with hand weeding at 15 and 30 DAS with cultivar Chakhao Poireiton and was followed with application of pretilachlor @ 1.0 kg ha-1 (PE) fb HW at 40 DAS. Hand weeding at 15 and 30 DAS along with cultivar Chakhao Poireiton exhibited highest plant height, LAI and biological yield and was closely followed with application of pretilachlor @ 1.0 kg ha-1 (PE) fb HW at 40 DAS with Chakhao Poireiton, while similar results were also observed with the phenological studies. Further, weedy check recorded lowest plant height and LAI. However, plant population showed no significant variation with context to integrated weed management and different cultivars in both the years. Additionally, correlation studies revealed a strong negative correlation between plant height and nutrient depletion by weeds.
Pore-Scale Study on Confined Aqueous Flow in Shale Nanopores with Effects of Clay Swelling and Mixed Wettability
Authors: Huang Jingwei , Li Yuanping , Xie Chenyue , Zhao Hui , Yin Xiaolong 
Published: February 2025

Summary
The confined fluid flow in nanopores is significantly influenced by the confined space and nanoscale phenomena. However, the mechanism of confined flow in shale matrix remains unclear due to the synthetic effects of clay swelling and mixed wettability. In this study, we analyzed confined aqueous flow in a 3D shale pore system using the lattice Boltzmann method. The impacts of clay swelling and wettability on the hydraulic conductivity of shale nanopores are quantified. Our study suggests that a hydrophobic surface increases the apparent permeability of shale nanopore. The decrease in permeability caused by clay swelling is more significant in water-wet shale. The relationship between permeability and porosity during clay swelling follows a power-law function, with the exponent being influenced by the contact angle. In addition, mixed wettability directly affects shale’s apparent permeability. It is shown that an elevated spatial distribution of water-repellent minerals results in an increased permeability. The process of clay swelling in mixed-wet shale is characterized by two distinct stages of permeability reduction. The boundary between these stages is determined by the volume fraction of water-repellent pores.
Statistical Analysis and Assessment of Transportation Effect on Air Pollution in in Falluja City, Iraq
Authors: Hammad Mohanad , Kareem Sabreen L. , Alnasrawi Fatin A. 
Published: February 2025

Abstract

Falluja City suffers from air pollution due to the increase in the number of vehicles, the intensity of their movement in city streets, and the organization of urban transport within the city. The aim of this study is the effect of transportation on the concentration of air pollutants such as CO, CO2, SO2, NO2, and HC in Fallujah. The concentrations of the mentioned pollutants were measured at nine traffic intersection locations, including Al-Hadra, Street 40, Maysaloun, East Fallujah, Alatifa, Kamalyat, Thathar, Al-Naziza, and Al-Takwa for five months period, starting from September (2023) to February (2024) The results showed that the highest CO concentration was in the Naziza area in November, reaching 2.85 ppm in the Naziza area, while the highest CO2 concentration was 400 ppm in the Hadara area in October. The highest concentration of NO2 reached the 40th Street area in November, while the SO2 concentration reached its maximum concentration in the 40th Street area, where it reached 0.78 ppm. As for the concentration of hydrocarbons, the highest concentration was 800 ppm in the 40th Street area in October. As for the spatial change, it is clear that the 40th Street area had a very high concentration of pollutants, and this is due to Traffic congestion at intersections. Statistical analysis of pollutant concentrations using one-way ANOVA using the Excel program it was understood that the variation in concentrations of different parameters based on stations are at P < 0.05 and significant since all F statistical values greater than F crit the null hypothesis can be rejected since There is evidence that not all the means are different.
The face of political social work in Zimbabwe
Authors: Mungwari Pride 
Published: February 2025

Abstract

Remedial and developmental methods have been dominating across different fields of social work practice. Even in social work literature, political social work methods have largely been scarce. This qualitative study explored what political social work looks like in Zimbabwe. A sample of seven social workers from different practice fields were drawn using snowballing and interviewed using an interview guide. The target was to sample 12 social workers from different practice fields. However, the study reached saturation at the 6th respondent. Data were analysed using thematic content analysis. Results show that political social work is practiced by a few social workers in human rights non-governmental organizations (NGOs) due to the risks and challenges associated with it in Zimbabwe. It is predominantly used as an indirect response to state perpetrated and systemic injustices. It also emerged that its practice is restricted by a host of challenges including security threats, lack of curriculum content on political social work, and a state that is intolerant to its critics. The findings can be useful in enhancing both political social work scholarship and practice in Zimbabwe. It is important that the Council of Social Work, National Association of Social Workers and various schools of social work in Zimbabwe improve curriculum content on political social work and collaboratively lobby government for recognition of political social work. The findings demonstrate incapabilities of remedial and developmental approaches to address social injustices in which the state is implicated. When properly structured, legally protected, and integrated with other social work methods, political social work can uproot systemic injustices affecting Zimbabwe.
Impact of Soil Additions Fertilizers and Foliar Chlorella Vulgaris Extract on Soil Properties and productivity of Lettuce Plant Grown Under Saline Soil Conditions
Authors: El-Tawwab Ahmed R. Abd , Abdel-Moatamed Basma R. , Gyushi Mohammed A. H. 
Published: February 2025

Abstract

Sustainable agriculture is essential for addressing global challenges such as climate change, food insecurity, and environmental degradation. This study, conducted at Fayoum University’s Demo Farm in Egypt, investigated the effects of mineral and organic amendments, combined with foliar application of Chlorella vulgaris extract, on soil properties and lettuce productivity in salt-affected soils during the 2022/2023 and 2023/2024 winter seasons. Treatments included compost (C), biochar (B), a compost-biochar blend (CB-blend), and mineral fertilizers, with or without Chlorella vulgaris extract foliar spray. Results revealed that the CB-blend significantly enhanced soil properties, including bulk density, hydraulic conductivity, organic matter, nutrient availability, and microbial activity. The combination of CB-blend (5 t fad− 1 of compost + 5 t fad− 1 of biochar were mixed) and a chlorella vulgaris extract (CVextr) 10% foliar spray increased lettuce yield by 194.68% compared to untreated soil, demonstrating improved growth parameters such as head weight, circumference, and leaf area. These findings highlight the synergistic benefits of organic amendments and bio-stimulants in improving soil health, crop resilience, and productivity under saline conditions. The study advocates for the adoption of compost, biochar, and chlorella vulgaris extract (CVextr) 10% foliar spray as sustainable alternatives to synthetic fertilizers, offering a viable strategy for organic farming systems to mitigate saline stress and promote environmental sustainability.
"Phytochemical Composition, Antioxidant Potential, and Insecticidal Activity of Moringa oleifera Extracts Against Tribolium castaneum: A Sustainable Approach to Pest Management"
Authors: Ghada Ben Khedher , Marwa Rezgui , Shah Tawaf Ali , Dabiellil Mutwakel , Dawoud Turki M. , Bourhia Mohammed , Tebra Triki , Hadhami Chargui , Tarek Slatni , Chiraz Chaffei-Haouari 
Published: February 2025

Abstract

Moringa oleifera, known for its rich phytochemical profile, offers a promising natural alternative for sustainable pest management. This study investigates the phytochemical composition, antioxidant activity, and evauates for the first time the insecticidal potential of M. oleifera extracts against Tribolium castaneum. Extracts were obtained from different plant parts (leaves, stems, roots, and seeds) using ethanol, methanol, acetone, and distillated water. Phytochemical analysis revealed high concentrations of total phenolics (7.18 µg GAE/mg DW in ethanol leaf extract), flavonoids (23.52 µg QE/mg DW in ethanol leaf extract), tannins (245.4 mg CE/g DW in acetone seed extract), saponins (13.7 in methanol leaf extract), and alkaloids (30.06 mg atropine/100mL in water stem extract). HPLC analysis identified various bioactive compound, including phenolic acids (gallic acid, caffeic acid, chlorogenic acid, ferulic acid), flavonoids (apigenin, quercetin, kaempferol), flavanols (catechin, epicatechin, procyanidin dimers), and iridoids (oleuroside). Among these, gallic acid, quercetin-3-O-rhamnoside and kaempferol were detected in high concentrations. Antioxidant assays showed significant free radical scavenging activity, with methanol root extract displaying the highest DPPH inhibition (7.1%). Total antioxidant activity peaked at 36.12 mg GAE/g DW in methanol stem extract. Insecticidal bioassays demonstrated that ethanol root extracts achieved 90% mortality of T. castaneum within 24 hours at a 30% concentration. These findings highlight M. oleifera as a potent bioinsecticide with strong antioxidant properties, supporting its integration into sustainable pest management strategies. Further research should focus on formulation stability and field application for large-scale use.
Route of fecal microbiota transplantation delivery determined the dynamics and predictability of donor microbe colonization
Authors: Oladele Paul , Dong Wenxuan , Richert Brian , Johnson Timothy A. 
Published: February 2025

Abstract

Background
Fecal microbiota transplantation (FMT) and the colonization of delivered donor microbes has been reported to improve the negative effects like decrease in body weight, diarrhea, and gut barrier disruption associated with weaning in pigs. However, delivery of FMT in pigs is still invasive and predicting the colonization or rejection of donor microbes remains challenging. Therefore, this study developed a non-invasive in-feed delivery of FMT and evaluated the effect of mode of delivery of FMT on growth performance, gut physiology, microbiota dynamics, and predictability of colonization or rejection of donor microbes in recipient pigs. Forty weaned piglets (10 per group) were administered FMT through one of three routes; oral, rectal, or amended in-feed. The control group was orally administered sterile saline to simulate the handling stress.
Result
Pigs in the FMT groups had higher average daily weight gain (ADG) from day 0–2 post-weaning. An increase in community diversity and a shift in the recipient community towards the donor in all FMT groups was observed on day 5. The oral group had the highest colonization (15.12%) and the lowest rejection (19.34%) rates, while colonization was 13.82% and 11.78% in rectal and in-feed group respectively. On day 4, colon crypt depth was increased in all FMT groups but an increase in villus length was only observed in the in-feed group. Colonization and rejection of donor microbes in the recipient animals could be predicted in all routes of FMT, but the efficacy of prediction was influenced by the route of delivery. In-feed FMT had the lowest colonization prediction which may have been influenced by the need for voluntary consumption of fecal materials in the in-feed group. The ten most abundant genera in the recipient prior to FMT (background community) was the most important feature in predicting colonization for all routes of fecal microbiota transplant.
Conclusion
FMT administered as a lyophilized feed additive shows promise in altering microbiome community structure. While colonization and rejection of donor microbes within the recipient community are predictable, the efficacy of these predictions varies with the route of transplant. This suggests that different prediction models are necessary for each delivery mode of FMT in pigs.
The Correlation Between Artificial Intelligence Literacy and Artificial Intelligence Anxiety in Audiology Students
Authors: Kuntman Berna Deniz , Polat Anı Parabakan 
Published: February 2025

Abstract

Background
Artificial intelligence (AI) is becoming progresivelly important in health sciences. It is therefore indispensable to assess health science students’ views, attitudes, awareness, knowledge, literacy and anxiety levels related to AI.
Aims
This study aims to evaluate the AI ​​literacy levels and AI anxiety levels of undergraduate audiology students and, additionally to evaluate the relationship between AI literacy and AI anxiety.
Method
A correlational research was designed. 231 undergraduate audiology students were enrolled in this research. The research data was collected through Artificial Intelligence Literacy Scale (AILS) and Artficial Intelligence Anxiety Scale (AIAS).
Results
The AILS score was 39.49±5.50, and AIAS was 46.13±12.31. Although correlations were found among various sub-dimensions, and between total scores and sub-dimensions of AILS and AIAS in audiology undergraduate students, there was no relationship between the total scores of AIAS and AILS (p < 0.05).
Conclusion
It is possible to assert that as awareness and usage sub-dimensions of artificial intelligence literacy increases, artificial intelligence anxiety decreases. Therefore, it can be suggested to increase artificial intelligence literacy levels and reduce artificial intelligence anxiety levels by including artificial intelligence training in the audiology curriculum.