bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative efficacy and tolerability of adjuvant systemic treatments against resectable colon cancer: a network meta-analysis
Authors: Cheng Ji , Shuai Xiaoming , Gao Jinbo , Wang Guobin , Tao Kaixiong , Cai Kailin 
Published: December 2020

Background: Currently, 6-month oxaliplatin-based chemotherapy has been recommended as the preferred adjuvant treatment against high-risk stage 2 and stage 3 colon cancer patients. Methods: Record retrieval was conducted in PubMed, Web of Science, Cochrane Central Register of Controlled Trials, American Society of Clinical Oncology and European Society for Medical Oncology meeting libraries from inception to November 2019. Regarding survival and tolerability, randomized controlled trials comparing different adjuvant systemic regimens against high-risk stage 2 and stage 3 colon cancer were eligible. Disease-free survival was primary endpoint. Network calculation was based on a random-effects model, and relative ranking of each node was numerically indicated by p score. Results: A total of 30 trials were included, corresponding to 54,109 patients. Regarding disease-free survival, none of the analyzed regimens displayed significant superiority against common comparator 6-month capecitabine plus oxaliplatin (XELOX), while 12-month [network hazard ratio (HR) 0.81 (0.60–1.10); 0.79 (0.57–1.10)] and 3-month XELOX [0.95 (0.86–1.04); 0.93 (0.83–1.05)] were top-ranking regimens showing non-inferiority among overall and stage 3 patients. Moreover, by pairwise meta-analysis, 3-month XELOX demonstrated significant superiority against 6-month XELOX among low-risk stage 3 patients [pairwise HR 0.78 (0.63–0.97)]. Concerning adverse events, 3-month oxaliplatin-based chemotherapy was significantly better than the 6-month counterpart with respect to peripheral sensory neuropathy, thrombocytopenia and fatigue. The 12-month capecitabine monotherapy failed to display non-inferiority among other major adverse events. Conclusions: The 3-month XELOX treatment could be an alternative option of the 6-month regimen among low-risk stage 3 patients. Among high-risk stage 3 patients, 6-month oxaliplatin-based regimens still seem more competitive. In addition, clinical application of 12-month capecitabine monotherapy should be cautious, despite its top rankings, especially among non-Asian countries.
Ruptures of the Plantar Fascia: A Systematic Review of the Literature
Authors: Mosca Massimiliano , Fuiano Mario , Massimi Simone , Censoni Davide , Catanese Giuseppe , Grassi Alberto , Caravelli Silvio , Zaffagnini Stefano 
Published: December 2020

Introduction Rupture of the plantar fascia is a rare condition. It can also occur spontaneously and with no history of disease of the plantar fascia, above all in athletes. This review aims to systematically analyze all cases described in the literature regarding the rupture of the plantar fascia, evaluating incidence, risk factors, and treatments, considering which procedures show the best outcomes and the highest success rate. Materials and methods A systematic review of PubMed, Google Scholar, and Cochrane review computerized databases was performed, focusing on articles about cases of rupture of the plantar fascia; 18 studies fulfilled all the criteria and were analyzed. There were no randomized controlled trials. Results A total of 155 patients (157 foot) were included in this systematic review. Considering all the studies included, 12 patients had a spontaneous rupture, 138 patients had a diagnosis of plantar fasciitis, and 130 patients were treated with local injections of corticosteroid before the rupture. Only 2 cases of bilateral rupture were reported. In all, 15 studies reported conservative treatment, with a total of 154 patients (156 feet) included. Operative treatment was reported in 3 studies, with 3 patients (3 feet) treated. Conclusions Ruptures of the plantar fascia are very rare in asymptomatic patients and more common in patients treated with injection of steroids in the plantar fascia. Conservative treatment, although not standardized in the literature, led to good outcomes in most cases. Chronic ruptures of the fascia should be considered for operative treatment. Levels of Evidence: Level III
Are cancer care pathways associated with longer waiting times. Analysing crowding out effects in radiology, pathology, and surgery
Authors: Olsson Olle 
Published: December 2020

Introduction In 2015, Sweden initiated the implementation of standardised cancer care pathways (CCPs). With short, nationally imposed target times from diagnosis to first treatment, the issue of crowding out effects has been debated. This study investigate whether the implementation of CCPs is associated with longer waiting times for surgery, radiology scans and pathology analyses for other patient groups. Methods Data from the internal computer systems used in radiology, pathology and surgery to plan and follow the production at a county hospital in Sweden during 2014–2017 were analysed. By utilising the different priority categories used in these specialties, changes in waiting times before and after the implementation of CCPs could be analysed. Results The results are consistent with an association between the implementation of CCPs and longer waiting times for the priority category prioritised immediately after the CCP category in all specialties. In addition, none of the lowest priority categories within each subspecialty have experienced increased waiting times after CCP implementation. Discussion These results are consistent with a change in prioritisation where CCP patients are receiving shorter waiting times after CCP implementation at the expense of other patient groups. Crowding out effects related to CCP implementation have not been previously researched. This study therefore fills a gap in present literature. With an increased awareness of these challenges, and a more holistic perspective in the implementation process, actions can be put in place to identify and counteract crowding out effects.
Outcomes of U-Blade Lag Screw for Cephalomedullary Fixation of Unstable Trochanteric Femur Fractures: A Case Control Study
Authors: Kang Joon Soon , Kwon Yong Tak , Suh Young Ju , Lee Tong Joo , Ryu Dong Jin 
Published: December 2020

Background: Unstable trochanteric femur fractures in elderly patients with osteoporosis are still challenging. Gamma3 nail with the U-blade lag screw (U-blade gamma nail) has been developed to improve mechanical stability of proximal femoral fragment. This study aimed to compare the clinical and radiologic outcomes of U-blade gamma nail to proximal femoral nail antirotation (PFNA), and standard Gamma3 nail (gamma nail) for unstable trochanteric femur fractures. Methods: A retrospective matched-pair case study was performed with U-blade gamma nail, PFNA, and gamma nail. During 2012-2018, 970 patients with unstable trochanteric femur fractures were reviewed. Matching criteria were set as follows: 1) sex; 2) age (± 3 years); 3) body mass index (± 2 kg/m2); 4) bone mineral density (± 1 T-score in femur neck). Finally, a total of 159 patients were enrolled. We assessed the tip-apex distance (TAD), neck shaft angle, and hip screw sliding distance using plain radiographs. Also, we evaluated the clinical outcomes with Koval’s grade and fixation failure during 2 years. Results: The mean postoperative TAD was not significantly different among the 3 groups (p = 0.519). However, the change in the TAD at 1 year (p = 0.027) and 2 years (p = 0.008) after surgery was significantly smaller in U-blade gamma nail group compared with PFNA and gamma nail group. The hip screw sliding distance at 1 year (p = 0.004) and 2 years (p = 0.001) after surgery was significantly smaller in U-blade gamma nail group compared with PFNA and gamma nail group. However, there was no significant difference of Koval’s grade and fixation failure among the 3 groups (p = 0.535). Conclusion: U-blade gamma nail showed favorable radiologic results in terms of the change in the hip screw position. However, U-blade gamma nail was not superior to PFNA and gamma nail in clinical outcomes.
Burning mouth syndrome: An update
Authors: Tan Huann Lan , Renton Tara 
Published: December 2020

Background: Burning mouth syndrome (BMS) is a chronic and debilitating oral pain of the normal oral mucosa. It mainly affects women in their fifth to seventh decade. Its aetiopathogenesis remains unclear and is probably of multifactorial origin, with increasing evidence that BMS may be a neuropathic disorder. BMS is classified as an idiopathic (nociplastic) orofacial pain with or without somatosensory changes by International Classification of Orofacial Pain (ICOP 2020). The diagnosis of BMS, having excluded ‘oral burning mouth symptoms’, has evolved from basic intraoral exclusion screening to extensive clinical and laboratory investigations, which include the screening of comorbidities and other chronic pains and somatosensory testing. There is no standardised treatment in managing BMS, but a proposed combination of supportive and pharmacological treatment has been recommended. Aim: To review the current concepts of BMS definitions, classifications, aetiopathogenesis, diagnosis techniques, and evidence-based treatments in managing BMS patients. Conclusion: As BMS is a diagnosis by exclusion, thus a stratified approach is required for assessment of patients presenting BMS. A BMS diagnosis protocol is desired using a standardised screening to distinguish BMS from patient’s presenting with ‘oral burning symptoms’, and evaluation of comorbid chronic pain disorders or other medical comorbidities, which will include haematological, fungal, salivary flow, and qualitative sensory testing. Axis II and other additional quantitative sensory testing may further elucidate the causes of this condition. For future BMS prediction and prevention, will be based upon research on the relationship between other chronic pain disorders and familial history, environmental and genetic information.
Using phosphate to increase feeding consumption in termite Coptotermes formosanus
Authors: Suhara Hiroto 
Published: December 2020

AbstractTermites are ecologically significant in positive and negative ways; their role in breaking down debris greatly benefits forest environments, but this activity renders them a pest in domestic environments. This study examines the effect of nutrition on the feeding preference of termite Coptotermes formosanus Shiraki. Among 11 nutrition options tested, dipotassium phosphate (DKP) most significantly increased feeding consumption in the multiple feeding choice test. The mean feeding amount of the DKP-treated sample was 2.5-fold higher than that of the deionized water-treated control. This result suggests that termite colonies are deficient in phosphorus, and an additional supply of phosphate can promote feeding. The result of a no-choice feeding test using DKP shows that DKP does not promote feeding in a small number of termites. The results obtained in this study suggest that phosphorus is needed in termite colonies, making DKP especially effective. DKP will help to improve bait technology, because it is inexpensive and safe for both humans and the environment.
Utilization of enzymatic hydrolysate from corn stover as a precursor to synthesize an eco-friendly adhesive for plywood II: investigation of appropriate manufacturing conditions, curing behavior, and adhesion mechanism
Authors: Zhao Zhongyuan , Wu Di , Huang Caoxing , Zhang Min , Umemura Kenji , Yong Qiang 
Published: December 2020

AbstractIn this study, further research on an enzymatic hydrolysate-ammonium dihydrogen phosphate (EHADP) adhesive was carried out. Appropriate hot pressing conditions were clarified by measuring the bond strength of three-ply plywood bonded with EHADP adhesive, and the results indicated that the appropriate fabricate conditions were 170 °C and 5 min. The value of wet shear strength fulfilled the requirements of China National Standard GB/T 9846–2015 when plywood was fabricated by the appropriate conditions. In the research of curing behavior, the insoluble mass proportion promoted significantly as heating temperature and time were ≥ 170 °C and 5 min. Furthermore, a pyrolysis gas chromatography/mass spectrometry analysis indicated that adding ammonium dihydrogen phosphate (ADP) catalyzed the conversion of monosaccharides in the EHADP adhesive. The adhesion mechanism of the EHADP adhesive was studied by Fourier transform-infrared spectroscopy analysis, and the chemical changes indicated that the adhesion mechanism was attributed to both mechanical and chemical bonding between the wood elements and the cured EHADP adhesive.
Does galvanic cathodic protection by aluminum anodes impact marine organisms?
Authors: Bell Anna Maria , von der Au Marcus , Regnery Julia , Schmid Matthias , Meermann Björn , Reifferscheid Georg , Ternes Thomas , Buchinger Sebastian 
Published: December 2020

Abstract
Background
Cathodic protection by sacrificial anodes composed of aluminum-zinc-indium alloys is often applied to protect offshore support structures of wind turbines from corrosion. Given the considerable growth of renewable energies and thus offshore wind farms in Germany over the last decade, increasing levels of aluminum, indium and zinc are released to the marine environment. Although these metals are ecotoxicologically well-studied, data regarding their impact on marine organisms, especially sediment-dwelling species, as well as possible ecotoxicological effects of galvanic anodes are scarce. To investigate possible ecotoxicological effects to the marine environment, the diatom Phaedactylum tricornutum, the bacterium Aliivibrio fischeri and the amphipod Corophium volutator were exposed to dissolved galvanic anodes and solutions of aluminum and zinc, respectively, in standardized laboratory tests using natural seawater. In addition to acute toxicological effects, the uptake of these elements by C. volutator was investigated.

Results
The investigated anode material caused no acute toxicity to the tested bacteria and only weak but significant effects on algal growth. In case of the amphipods, the single elements Al and Zn showed significant effects only at the highest tested concentrations. Moreover, an accumulation of Al and In was observed in the crustacea species.

Conclusions
Overall, the findings of this study indicated no direct environmental impact on the tested marine organisms by the use of galvanic anodes for cathodic protection. However, the accumulation of metals in, e.g., crustaceans might enhance their trophic transfer within the marine food web.
Gender wage gap in China: a large meta-analysis
Authors: Iwasaki Ichiro , Ma Xinxin 
Published: December 2020

AbstractThis paper performs a meta-analysis of 1472 estimates extracted from 199 previous studies to investigate the gender wage gap in China. The results show that, although the gender wage gap in China during the transition period has an impact that statistically significant and economically meaningful, it remains at a low level. It is also revealed that the wage gap between men and women is more severe in rural regions and the private sector than those in urban regions and the public sector. Furthermore, we found that, in China, the gender wage gap has been increasing rapidly in recent years.
Flora Capture: a citizen science application for collecting structured plant observations
Authors: Boho David , Rzanny Michael , Wäldchen Jana , Nitsche Fabian , Deggelmann Alice , Wittich Hans Christian , Seeland Marco , Mäder Patrick 
Published: December 2020

Abstract
Background
Digital plant images are becoming increasingly important. First, given a large number of images deep learning algorithms can be trained to automatically identify plants. Second, structured image-based observations provide information about plant morphological characteristics. Finally in the course of digitalization, digital plant collections receive more and more interest in schools and universities.

Results
We developed a freely available mobile application called Flora Capture allowing users to collect series of plant images from predefined perspectives. These images, together with accompanying metadata, are transferred to a central project server where each observation is reviewed and validated by a team of botanical experts. Currently, more than 4800 plant species, naturally occurring in the Central European region, are covered by the application. More than 200,000 images, depicting more than 1700 plant species, have been collected by thousands of users since the initial app release in 2016.

Conclusion
Flora Capture allows experts, laymen and citizen scientists to collect a digital herbarium and share structured multi-modal observations of plants. Collected images contribute, e.g., to the training of plant identification algorithms, but also suit educational purposes. Additionally, presence records collected with each observation allow contribute to verifiable records of plant occurrences across the world.
Assessment of differences in morphological and physiological leaf lodging characteristics between two cultivars of Hippeastrum rutilum
Authors: Shi Zhenjie , Zheng Qianjiao , Sun Xiaoyang , Xie Fuchun , Zhao Jian , Zhang Gaoyun , Zhao Wei , Guo Zhixin , Ariunzul Ariuka , Fahad Shah , Adnan Muhammad , Qin Dong , Saud Shah , Yajun Chen 
Published: December 2020

Abstract
Background
Environmental lodging stress, which is a result of numerous factors, is characterized by uncertainty. However, several studies related to lodging in cereal crops have reported that lodging in the Hippeastrum rutilum environment is very rare. Hippeastrum rutilum is a garden flower with high ornamental value and abundant germplasm resources. Under past cultivation practices, it was found that the plant types of ‘Red Lion’, with red flowers, and ‘Apple Blossom’, with pink flowers, are quite different. The leaves of ‘Red Lion’ are upright, while the leaves of ‘Apple Blossom’ show lodging, which seriously affects its ornamental value. The aims of this study were to compare the differences between the two varieties with leaf lodging and upright leaves according to morphological and physiological attributes. In this study, karyotype analysis and phenotypic morphological and physiological characteristics were compared to explore the differences between the two plant types.

Results
The karyotype analysis of the two cultivars showed that their chromosome types were both tetraploid plants. The results showed that the lignin content in the leaves of ‘Red Lion’ was high, the cross-sectional structure of the leaf vascular bundle was more stable, and the chlorophyll content was high. In addition, significantly less energy was transferred to the electron transport chain (ETR) during the photoreaction. Similarly, the results regarding the maximum photosynthetic rate (Fv/Fm), nonphotochemical quenching (NPQ) and effective quantum yield of photosystem II photochemistry (△F/Fm′) all indicated that the photosynthetic capacity of “Red Lion” was greater than that of “Apple Blossom”, which was affected by leaf lodging. The size of the leaves was significantly smaller, and the leaf sag angle, leaf width, and leaf tip angle presented significantly lower values in ‘Red Lion’ than in ‘Apple Blossom’, which exhibits leaf sag. The difference in these factors may be the reason for the different phenotypes of the two cultivars.

Conclusion
The results of this study proved that lodging affects the photosynthetic capacity of Hippeastrum rutilum and revealed some indexes that might be related to leaf lodging, laying a theoretical foundation for cultivating and improving new varieties.
Discussing personalized prognosis in amyotrophic lateral sclerosis: development of a communication guide
Authors: van Eenennaam Remko M. , Kruithof Willeke J. , van Es Michael A. , Kruitwagen-van Reenen Esther T. , Westeneng Henk-Jan , Visser-Meily Johanna M. A. , van den Berg Leonard H. , Beelen Anita 
Published: December 2020

Abstract
Background
Personalized ENCALS survival prediction model reliably estimates the personalized prognosis of patients with amyotrophic lateral sclerosis. Concerns were raised on discussing personalized prognosis without causing anxiety and destroying hope. Tailoring communication to patient readiness and patient needs mediates the impact of prognostic disclosure. We developed a communication guide to support physicians in discussing personalized prognosis tailored to individual needs and preferences of people with ALS and their families.

Methods
A multidisciplinary working group of neurologists, rehabilitation physicians, and healthcare researchers A) identified relevant topics for guidance, B) conducted a systematic review on needs of patients regarding prognostic discussion in life-limiting disease, C) drafted recommendations based on evidence and expert opinion, and refined and finalized these recommendations in consensus rounds, based on feedback of an expert advisory panel (patients, family member, ethicist, and spiritual counsellor).

Results
A) Topics identified for guidance were 1) filling in the ENCALS survival model, and interpreting outcomes and uncertainty, and 2) tailoring discussion to individual needs and preferences of patients (information needs, role and needs of family, severe cognitive impairment or frontotemporal dementia, and non-western patients). B) 17 studies were included in the systematic review. C) Consensus procedures on drafted recommendations focused on selection of outcomes, uncertainty about estimated survival, culturally sensitive communication, and lack of decisional capacity.
Recommendations for discussing the prognosis include the following: discuss prognosis based on the prognostic groups and their median survival, or, if more precise information is desired, on the interquartile range of the survival probability. Investigate needs and preferences of the patients and their families for prognostic disclosure, regardless of cultural background. If the patient does not want to know their prognosis, with patient permission discuss the prognosis with their family. If the patient is judged to lack decisional capacity, ask the family if they want to discuss the prognosis. Tailor prognostic disclosure step by step, discuss it in terms of time range, and emphasize uncertainty of individual survival time.

Conclusion
This communication guide supports physicians in tailoring discussion of personalized prognosis to the individual needs and preferences of people with ALS and their families.