bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphometric study of suprascapular notch and scapular dimensions in Ugandan dry scapulae with specific reference to the incidence of completely ossified superior transverse scapular ligament
Authors: Adewale Adesanya Olamide , Segun Okeniran Olatayo , Usman Ibe Michael , Monima Ann Lemuel , Kegoye Eric Simidi , Kasozi Keneth Iceland , Nalugo Halima , Ssempijja Fred 
Published: October 2020

Abstract
Background: Understanding of suprascapular notch (SSN) anatomy and relationship with scapular dimensions are vital in diagnosis, prevention, and assessment of suprascapular nerve entrapment syndrome. The study aimed to assess morphometry of suprascapular notch and scapular dimensions in Ugandan dry scapulae with specific reference to scapulae with completely ossified superior transverse scapular ligaments. Methods: This was a cross-sectional analytical study conducted on 50 Ugandan dry scapulae. SSN types and prevalence of completely ossified superior transverse scapular ligament among dry scapulae were quantified and compared with previous data. Scapular dimensions were assessed by measuring scapular length (A), scapular width (B), glenoid length (C), and glenoid width (D). One-way ANOVA was used to compare scapular dimensions of scapulae with different SSN types, and Spearman’s correlation coefficient was used to evaluate the correlation coefficient of scapular dimensions amongst groups. Results: Superior transverse scapular ligament (STSL) was completely ossified in 8% of cases. There was no significant (P > 0.05) difference between scapular dimensions of scapulae with completely ossified STSL compared to scapulae with other SSN types. Scapulae with completely ossified STSL showed strong negative (r = -0.89137, r = -0.877) correlations for its A, B respectively compared against D, this finding was not true to scapulae of other SSN types. Also, there were strong positive or negative (r > 0.7, r > -0.7) correlations: for A, types I and III compared to type VI; for B, types I, III compared to VI; for C, type IV and VI; and for D, type III and VI. Conclusions: The prevalence of completely ossified STSL is moderately high in the Ugandan population. Characteristics of the scapula (scapular dimensions) are not ‘vital’ but rather important or relevant for shoulder pathology with specific reference to suprascapular nerve entrapment syndrome due to completely ossified superior transverse scapular ligaments. Further correlation analyses of scapular dimensions of different SSN types in different populations are important.
A New Method for the Empirical Conversion of Logging Data to Clay Mineral Fraction in the Nankai Accretionary Prism
Authors: Yabe Suguru , Fukuchi Rina , Hamada Yohei , Kimura Gaku 
Published: October 2020

Abstract
Sediment lithology, especially the clay mineral fraction, is basic geologic information, which is important for understanding faulting and evolutionary process of the accretionary prism. During scientific drilling, the clay mineral fraction is measured using X-ray diffraction analyses of samples from the acquired cores. However, coring in an accretionary prism is sometimes difficult, which hinders the acquisition of clay mineral fraction data. This study details the development of a new method used to empirically estimate the clay mineral fraction from the electrical resistivity and natural gamma ray logs obtained from the Kumano section of the Nankai Tough, where multiple scientific drilling expeditions have been conducted. This method is composed of two steps. First, porosity is estimated using electrical resistivity logs. In order to compensate for the effect of porosity, the natural gamma ray logs are then normalized using (1 – porosity). Second, the normalized natural gamma ray logs are converted into clay mineral fractions using an empirical conversion function. This empirical function was determined by comparing all available normalized natural gamma ray logs and clay mineral fractions data collected from the Kumano section of the Nankai Trough. As a byproduct of the porosity estimations, thermal conductivity and temperature depth profiles were also estimated for all of the logging sites. As electrical resistivity logs and natural gamma ray logs are essential measurements made during scientific drilling, this new method can be applied to future drilling expeditions in the Nankai Trough. Although the empirical conversion function established in this study is valid only at the Kumano section of the Nankai trough, the same procedure can be applicable to other subduction zones to establish local empirical conversion functions if enough data are available. The clay mineral fraction depth profile estimated using this method can provide useful information for various geological studies, including sedimentology and structural geology of the shallow accretionary prism.
A Modified Delphi to Define Drug Dosing Errors in Pediatric Critical Care
Authors: Roumeliotis Nadia , Pullenayegum Eleanor , Rochon Paula , Taddio Anna , Parshuram Chris 
Published: October 2020

Abstract
Background There is no globally accepted definition for dosing error in adult or pediatric practice. The definition of pediatric dosing error varies greatly in the literature. The objective of this study was to develop a framework, informed by a set of principles, for a clinician-based definition of drug dosing errors in critically ill children, and to identify the range that practitioners agree is a dosing error for different drug classes and clinical scenarios.Methods We conducted a nationwide three staged modified Delphi from May to December 2019. Expert clinicians included Canadian pediatric intensive care unit (PICU) physicians, pharmacists and nurses, with a least 5 years’ experience. Outcomes were underlying principles of drug dosing, and error thresholds, as defined by proportion above and below reference range, for common PICU medications and clinical scenarios. Results Forty-four participants met eligibility, and response rates were 95, 86 and 84% for all three rounds respectively. Consensus was achieved for 13 of 15 principles, and 23 of 30 error thresholds. An over-dosed drug that is intercepted, an under-dose of a possibly life-saving medication, dosing 50% above or below target range and not adjusting for a drug interaction were agreed principles of dosing error. Altough there remained much uncertainty in defining dosing error, expert clinicians agreed that, for most medication categories and clinical scenarios, dosing over or below 10% of reference range was considered an error threshold.Conclusion Dosing principles and threshold are complex in pediatric critical care, and expert clinicians were uncertain about whether many scenarios were considered in error. For most intermittent medications, dosing over 10% below or above reference range was considered a dosing error, although this was largely influenced by clinical context and drug properties. This consensus driven error threshold will help guide routine clinical dosing practice, standardized reporting and drug quality improvement in pediatric critical care.
Knowledge and attitudes among preschools staff in Shanghai, China, regarding epilepsy
Authors: Qiu Liyan , Shen Lixiao , Wang Junli , Ren Fang , Xu Mingyu , Jiang Fan , Sheng Xiaoyang , Li Fei , Li Feng 
Published: October 2020

Abstract
Background
Epilepsy is one of the most common neurological problems among children. The aim of this survey was to assess the knowledge and attitude among preschool staff in Shanghai regarding epilepsy.
Methods
A cross-sectional survey was carried out among the staff at selected preschools. A stratified random sampling method was first used to identify suitable subjects. Data were obtained using a self-completed questionnaire. A standardized collection of demographic information was performed, and participants were given a questionnaire about their knowledge and attitudes regarding epilepsy.
Results
A total of 1069 subjects completed the questionnaire. In this survey, 387 (36.2%) staff members had previously participated in related training. Overall, the subjects lacked knowledge regarding first aid for seizures. Only 17.6% of teachers knew how to provide appropriate first aid for seizures. Correct responses regarding first aid for seizures, such as laying the person on his or her side (24.9%), moving harmful objects out of the way (20.7%), protecting the head (36.1%), waiting until the seizure ends (7.9%), and dialing the emergency number (40.1%), were low. The staff members had different attitudes towards children with epilepsy: most had a positive attitude, but some had a negative attitude.
Conclusions
The level of first-aid knowledge among preschool staff in Shanghai relevant to epilepsy was low. There is an urgent need to educate staff about epilepsy and appropriate first-aid practices for seizures.
Keywords : Epilepsy; Preschool staff; First-aid knowledge; Attitudes; Training
The Combination of Trehalose and Glycerol: An Effective and Non-Toxic Recipe for Cryopreservation of Human Adipose-Derived Stem Cells
Authors: Zhang Tian-Yu , Tan Poh-Ching , Xie Yun , Zhang Xiao-Jie , Zhang Pei-Qi , Gao Ying-Ming , Zhou Shuang-Bai , Li Qing-Feng 
Published: October 2020

Abstract
Background: Adipose-derived stem cells (ADSCs) promote tissue regeneration and repair. Cryoprotective agents (CPAs) protect cells from cryodamage during cryopreservation. Safe and efficient cryopreservation of ADSCs is critical for cell-based therapy in clinical applications. However, most CPAs are used at toxic concentrations, limiting their clinical application. Objective: The aim of this study is to develop a non-toxic xeno-free novel CPA aiming at achieving high-efficiency and low-risk ADSC cryopreservation.Methods: We explored different concentrations of trehalose (0.3 M, 0.6 M, 1.0 M, and 1.25 M) and glycerol (10%, 20%, and 30% v/v) for optimization and evaluated and compared the outcomes of ADSCs cryopreservation between a combination of trehalose and glycerol and the commonly used CPA DMSO (10%) + FBS (90%). All samples were slowly frozen and stored in liquid nitrogen for 30 days. The effectiveness was evaluated by the viability, proliferation, migration and multi-potential differentiation of the ADSCs after thawing. Results: Compared with the groups treated with individual reagents, the 1.0 M Tre + 20% Gly group showed significantly higher efficiency in preserving ADSC activities after thawing, with better outcomes in both cell viability and proliferation capacity. Compared with the 10% DMSO + 90% FBS treatment, the ADSCs preserved in 1.0 M Tre + 20% Gly showed similar cell viability, surface markers and multi-potential differentiation but a significantly higher migration capability. The results indicated that cell function preservation can be improved by 1.0 M Tre + 20% Gly. Conclusions: The 1.0 M Tre + 20% Gly treatment preserved ADSCs with a higher migration capability than 10% DMSO + 90% FBS and with viability higher than that with trehalose or glycerol alone but similar to that with 10% DMSO + 90% FBS and fresh cells. Moreover, the new CPA achieves stemness and multi-potential differentiation similar to those in fresh cells. Our results demonstrate that 1.0 M Tre + 20% Gly can more efficiently cryopreserve ADSCs and is a non-toxic CPA that may be suitable for clinical applications.
Provider-Perceived Benefits and Constraints of Complete Adherence to Antenatal Care Guideline Among Public Health Facilities, Ethiopia: A Qualitative Study
Authors: Seyoum Tewodros , Alemayehu Mekuriaw , Christensson Kyllike , Lindgren Helena 
Published: October 2020

Abstract
Background: In Ethiopia, health care providers’ level of adherence to the national Antenatal Care (ANC) guideline is relatively low. The reasons why they do not follow the guidelines are not well known. Therefore, this study aimed to explore the provider-perceived benefits and constraints associated with using the guideline for ANC in public health facilities in Gondar town.Methods: A qualitative study was conducted using a semi-structured interview guide. The interview was conducted among a purposive sample of nine health care providers working in four public health facilities in Gondar town. After the interviews were transcribed and coded, a content analysis was done using Atlas ti version 7.5 software packages.Result: Decreasing provider’s workload and maximizing performance, improving safe motherhood, and improving the process of service delivery were reported as the perceived benefits of following ANC guideline. Organizational problems, care providers' existing knowledge, attitude, and skills and availability of training and mentorship were the three main identified groups of factors that hinder complete providers’ adherence to ANC guideline.Conclusion: Although providers acknowledged the benefits of following ANC guideline, the guideline is not fully implemented. Refresher training should be given at the start of the updated eight-contact ANC guideline and continuing education and supervision throughout the implementation process. Health care providers call for profound and urgent revisions of the supply chain system for supplies and equipment.
Characteristic Latent Features for Analyzing Digital Mental Health Interaction and Improved Explainability
Authors: Theilig Max-Marcel , Knapp Ashley Arehart , Nicholas Jennifer , Zarnekow Rüdiger , Mohr David Curtis 
Published: October 2020

Abstract
Background: Using smartphones and wearable sensor technology has sparked a broad engagement of data science and machine learning methods to leverage the complex, assorted amount of data. Despite verified processes, there is a reported underdevelopment of user engagement concepts, and the desire for high accuracy or significance has shown to lead to low explicability and irreproducibility. To overcome these issues, we aim to analyze principal characteristics of everyday behavior in digital mental health. Methods: We generated five latent features based on previous research, expert opinions from digital mental health, and informed by data. The features were analyzed with descriptive statistics and data visualization. We carried out two rounds of evaluations with data from 12,400 users of IntelliCare, a mental health platform with 12 apps. First, we focused to proof concept and second, we assessed reproducibility by drawing conclusion from distribution differences. User data was drawn from both research trials and public deployment on Google Play. Results: Our algorithms showed increased rationale for the basic usage of apps with different underlying behavioral strategies. Measures of the distribution of user’s allocated attention, the user’s circadian behavior, their consecutive commitment to a specific strategy, and users’ interaction trajectory are perceived as transferable to the public data set. Because distributions between research trial and public deployment were similar, consistency was shown regarding the underlying behavioral strategies: psychoeducation and goal setting are used as a catalyst to overcome the users’ primary obstacles, sleep hygiene is addressed most regularly, while regular self-reflective thinking is avoided. Relaxation as well as cognitive reframing have increased variance in commitment among public users, indicating the challenging nature of these apps. The relative course of the engagement (learning curve) is similar in research and public data. Conclusions: The deliberate, a-priori engineered features were reproducible across app users from both data sets. These features led to improved results as well as increased interpretability, providing an increased understanding of how people engage with multiple mental health apps over time. Since we based the generation of features on generic interaction proxies, these methods are applicable to other cases in artificial intelligence and digital health.
Permaculture: Smart Growth Strategies for Juniper Forest
Authors: Akhtar Faiza , Shahkhan Safdar , Lodhi Sulman Aziz 
Published: October 2020

Abstract
Permaculture creates an integrated system by incorporating those parameters which are often viewed as separate entities such as smart growth, low-impact development, habitat protection, complete streets, and other initiatives. Its gives better planning options and give policies a line of coherence and directions which provides basis for the real concept of sustainability. Presently in Pakistan, forest management policies suffer from a number of drawbacks and especially the Juniper forests in Pakistan are under constant pressure due to natural as well as anthropogenic pressures. To conserve the Juniper Forest Ecosystem a proposed Smart Growth Strategies based on Permaculture’s principles are designed to protect the Ziarat Juniper Forest that offers an unequivocal vision and strategy to gain valid sustainability in forest management.
Metatranscriptomics to characterize respiratory virome, microbiome, and host response directly from clinical samples
Authors: Rajagopala Seesandra , Bakhoum Nicole , Pakala Suman , Shilts Meghan , Rosas-Salazar Christian , Mai Annie , Boone Helen , McHenry Rendie , Yooseph Shibu , Halasa Natasha , Das Suman 
Published: October 2020

Abstract
We developed a metatranscriptomics method that can simultaneously capture the respiratory virome, microbiome, and host response directly from low-biomass clinical samples. Using nasal swab samples, we have demonstrated that this method captures the comprehensive RNA virome with sufficient sequencing depth required to assemble complete genomes. We find a surprisingly high-frequency of Respiratory Syncytial Virus (RSV) and Coronavirus (CoV) in healthy children, and a high frequency of RSV-A and RSV-B co-infections in children with symptomatic RSV. In addition, we have characterized commensal and pathogenic bacteria, and fungi at the species-level. Functional analysis of bacterial transcripts revealed H. influenzae was highly active in symptomatic RSV subjects. Host transcriptome shows upregulation of the innate immune system, antiviral response and inflammasome pathway, and down regulation of fatty-acids pathway. This method is broadly applicable to infer transcriptome landscape of an infected system, surveil respiratory infections, and to sequence RNA viruses directly from clinical samples.
Factors Associated With Self-Efficacy Toward Healthy Eating and Physical Activity Among Kuwaiti Adolescent Girls
Authors: AlGhanim Latifa , Alkazemi Dalal Usamah Zaid 
Published: October 2020

Abstract
Background: The factors that may influence adolescents’ health-related behaviors in Kuwait are unclear. We hypothesized that girls’ self-efficacy would be negatively associated with their weight statuses and positively associated with healthy eating-related behaviors. This study aimed to measure healthy eating-related parameters, including self-efficacy, dietary habits, dietary beliefs, nutrition knowledge, and physical activity, in a sample of Kuwaiti adolescent girls and assess the correlates of self-efficacy, including weight status and dietary and health behaviors. Methods: In this cross-sectional, self-administered survey at the school level, we evaluated students of three schools in different governorate locations in Kuwait. The participants were adolescent girls (n=301; mean age, 16.6±1.2 years) who attended secondary schools. The main outcome measures were self-efficacy, dietary habits, dietary beliefs, nutrition knowledge, physical activity, and weight status per body mass index (BMI) categories. Pearson’s correlation analysis was performed to determine the associations among the healthy behavior related parameter scores. The independent samples t-test was used to examine the differences in scores between participants’ characteristics and self-efficacy scores (SES). Multivariate regression analysis was used to determine the final independent correlates of SES.Results: Only 19.9% of the participants had high self-efficacy toward healthy eating behaviors, 20.9% had “satisfactory eating habits,” 11.3% had a good comprehension of the meanings of healthy and unhealthy dietary habits and food, 16.3% had good nutrition knowledge, and 29.2% had an active lifestyle. SES was negatively correlated with BMI (r=-0.074, P=0.03) and positively correlated with all domains of healthy eating and physical activity. However, SES was not associated with nutritional knowledge. The independent correlates of SES in the multivariate regression analysis were governorate, eating beliefs, healthy eating score, and physical activity (R2=38.3%).Conclusions: Adolescent girls in Kuwait demonstrated a high level of self-efficacy toward healthy eating and behaviors and had firm nutritional beliefs; however, they failed to translate their beliefs into good nutritional habits. It is necessary to develop interventional nutrition programs at the school level that aim at improving healthy behaviors among adolescents.
Improving Birth Preparedness and Complication Readiness Through an Integrated Microfinance and Health Literacy Program:Evidence From Rural India
Authors: Ahmad Danish , Mohanty Itismita , Niyonsenga Theo 
Published: October 2020

Abstract
Background:Despite maternal mortality rate almost halving over the past two decades, approximately 295,000 deaths occurred annually in 2017 globally. They occur in high burden regions where most preventable deaths are precipitated by delays in maternal care provision. Recently, a novel rapidly scalable community-based program combining maternal health literacy delivery through microfinance-based women-only self-help groups (SHG) was implemented in rural India. We evaluated the impact of the IMFHL program on BPCR practice by women in one of India’s poorest states-Uttar Pradesh, adjusting for community, household and individual variables. We also investigated if there is a diffusion of knowledge of BPCR from SHG members receiving the health literacy intervention to non-members in program villages.Method: Using secondary survey data from the IMFHL project, we analysed data from 17,244 women across SHG and non-member households in Uttar Pradesh. We performed multivariable logistic regressions to estimate adjusted IMFHL program’s effects on maternal BPCR practice.Results: Membership in SHG alone is positively associated with BPCR practice with 17 percent higher odds compared to women in villages without the programs. Furthermore, the odds of practising complete BPCR increases by almost fifty percent when a maternal health literacy component is added to the SHGs. A diffusion effect was found for BPCR practice from SHG members to non-members only when an added health literacy component was integrated into the SHG model. The main effect of the IMFHL program on BPCR practice remained stable in the presence of confounders suggesting that the delivery of health messages is undiluted by other non-programmatic factors at the individual, household and community level. Among confounders, only the poorest households as captured by the wealth quintile were significantly negatively associated with BPCR practice.Conclusion: The public health literature promotes the adoption of BPCR practices to improve maternal health outcomes. This study shows that SHGs exert both a dissemination effect of planned health behaviour within members, as well as facilitate a diffusion effect of the natural transfer of BPCR from members to non-members when SHGs are enriched with a health literacy component