bluuebunny/crossref_metadata_2025_split huggingface dataset:
PEMANFAATAN KARBON AKTIF SAMPAH PLASTIK UNTUK MENURUNKAN BESI DAN MANGAN TERLARUT PADA AIR SUMUR
Authors: Hendrasarie Novirina , Prihantini Rani 
Published: October 2020

Air tanah atau biasa disebut air sumur umumnya terdapat ion besi (Fe) dan mangan (Mn) bervalensi dua secara bersamaan. Menurut hasil uji awal air sumur didapatkan parameter besi (Fe) 3,66 mg/L dan mangan (Mn) 2,75 mg/L. Fe dan Mn dalam air jika melebihi baku mutu (Fe 1 mg/L dan Mn 0,5 mg/L) dapat menyebabkan kekeruhan, korosi dan, bersifat neurotoksik. Teknologi yang umum digunakan untuk menyisihkan Fe dan Mn adalah adsorpsi. Penelitian ini bertujuan untuk memanfaatkan sampah plastik sebagai adsorben dalam menyisihkan parameter Fe, Mn dan, kekeruhan secara fixed bed column. Pada penelitian pendahuluan rasio Cn/Co 0,05 berada tepat pada waktu 40 menit dan jenuh pada 120 menit. Pada penelitian ini debit ditetapkan 10 ml/menit, kemudian digunakan variasi jenis plastik (PET, PVC, BPA free, LDPE) dan berat adsorben (60, 70, 80 gram). Dari hasil penelitian ini jenis plastik PET paling optimal menyisihkan Fe 94%, Mn 94% dan, kekeruhan 89% dengan berat 80 gram. Nilai kapasitas serap (qo) dalam pemodelan Thomas Fe 0,146 mg/g dan Mn 0,134 mg/g. Kata kunci: Adsorpsi, air sumur, kandungan besi dan mangan, pemodelan thomas, pirolisis, sampah plastik. Water is one of the natural resources that has a very function important for human life, besides that water is also an important component of the environment for the survival of humans and other living things. Ground water or commonly called well water generally contains iron (Fe) and manganese (Mn) ions with two valves simultaneously. According to the results of the initial test well water parameters Fe 3.66 mg/L and Mn 2.75 mg/L. Fe and Mn in water if they exceed the quality standard (Fe 1 mg/L and Mn 0.5 mg/L) can cause turbidity, corrosion and, are neurotoxic. The technology commonly used to remove Fe and Mn is adsorption. This study aims to utilize plastic waste as an adsorbent in removing Fe, Mn and, turbidity parameters by fixed bed column. In the preliminary study the 0.05 Cn/Co ratio was precisely at 40 minutes and was saturated at 120 minutes. In this study the discharge is set at 10 ml/min, then variations in the type of plastic (PET, PVC, BPA free, LDPE) and weight of the adsorbent (60, 70, 80 grams) are used. From the results of this study the most optimal type of PET plastic is to set aside 94% Fe, Mn 94% and 89% turbidity with a weight of 80 grams. The value of absorption capacity (qo) in modeling Thomas Fe is 0.146 mg/g and Mn 0.134 mg/g. Keywords: Adsorption, iron and manganese, pyrolysis of plastic waste, thomas modeling, well water.
POTENSI PENURUNAN EMISI GAS RUMAH KACA (GRK) DALAM KEGIATAN BELAJAR DI RUMAH SECARA ON-LINE: ANALISIS JEJAK KARBON (CARBON FOOTPRINT ANALYSIS)
Authors: Ismail Amrizarois 
Published: October 2020

Emisi karbon Gas Rumah Kaca (GRK) yang dihasilkan dalam penyelenggaraan pendidikan di Perguruan Tinggi dapat dikatakan cukup tinggi. Akumulasi karbon menjadi penyebab efek rumah kaca yang berdampak pada peningkatan suhu bumi atau disebut pemanasan global dan menimbulkan bencana ekologis. Pandemi Covid 19 telah memaksa proses belajar di rumah, secara otomatis hal tersebut mendorong adanya jeda dalam penggunaan energi dari alat elektronik dan kendaraan bermotor yang juga berarti terjadi penurunan Emisi GRK dari energi tersebut. Tujuan penelitian ini adalah untuk mengetahui besaran jejak karbon yang dihasilkan selama proses pembelajaran di kampus, sekaligus potensi penurunan Emisi karbon oleh belajar dari rumah. Metode penelitian adalah kuantitatif melalui pendekatan berbasis analisis jejak karbon sebagai instrumen untuk menghitung jumlah karbondioksida (CO2) dari kegiatan manusia. Selanjutnya dilakukan konversi nilai energi listrik (KWh) dan bahan bakar minyak (Liter/jam) menjadi besaran carbon GRK yang dihasilkan (CO2 α) dari kegiatan belajar/perkuliahan secara tatap muka dalam kelas. Hasil penelitian menunjukkan besaran jejak karbon yang diperoleh dari kuliah tatap muka, kemudian diturunkan melalui belajar di rumah sebesar 749.868 Kg untuk simulasi 100 kelas/tahun. Diharapkan pengurangan Emisi GRK melalui pembelajaran di rumah ini dapat menjadi satu habituasi baru pasca wabah Covid 19. Kata kunci: Belajar di rumah, jejak karbon, gas rumah kaca. ABSTRACT Greenhouse Gas (GHG) carbon emissions generated in the implementation of education in Higher Education can be said to be quite high. The accumulation of carbon causes the greenhouse effect which has an impact on increasing the temperature of the earth or is called global warming and causing ecological disasters. The Covid 19 pandemic has forced the learning process at home, automatically this has led to a pause in the use of energy from electronic devices and motorized vehicles which also means a reduction in GHG emissions from this energy. The purpose of this study was to determine the amount of carbon footprint generated during the learning process on campus, as well as the potential for reducing carbon emissions by learning from home. The research method is quantitative through an approach based on carbon footprint analysis as an instrument to calculate the amount of carbon dioxide (CO2) from human activities. Furthermore, the value of electrical energy (KWh) and fuel oil (Liters / hour) is converted into the amount of carbon GHG produced (CO2 α) from face-to-face learning activities in class. The results showed that the amount of carbon footprint obtained from face-to-face lectures, then reduced through home study, was 749,868 kg for a simulation of 100 classes / year. It is hoped that reducing GHG emissions through learning at home can become a new habituation after the Covid 19 outbreak. Keywords: Carbon footprint, greenhouse gases, home study.
A DIGNIDADE HUMANA NO PENSAMENTO DE KANT COMO FUNDAMENTO DO PRINCÍPIO DA LEALDADE PROCESSUAL
Authors: Pinheiro Marques Vinicius , Pereira Lorentino Sérgio Augusto , Ribeiro de Carvalho Rubem 
Published: October 2020

Este artigo teve como delimitação de tema e também questão central a possibilidade da aplicação do pensamento Kantiano sobre dignidade humana como fundamento do princípio lealdade processual. Para tanto, não só identificou a idéia do autor como, brevemente, descreveu a natureza jurídica da jurisdição, da relação jurídica processual, para relacionar ao final com o princípio da lealdade processual. A relevância do artigo está na evidente necessidade de se ter movimentos teóricos e construções normativas que acompanhem as transformações sociais considerando um sistema que vem se fundamentando na dignidade humana, sendo objetivo essencial na construção de uma sociedade livre, justa e solidária. Utilizando-se como referencial teórico a idéia de dignidade aventada pelo filósofo Immanuel Kant, foi desenvolvida uma pesquisa exploratória com abordagem qualitativa, cuja vertente metodológica é de procedimento bibliográfico teórico-documental, sob um ângulo dogmático, utilizada como forma de analisar os resultados. Concluiu-se que a percepção Kantiana sobre a dignidade humana pode fundamentar o princípio da lealdade processual.
CONSIDERAÇÕES JURÍDICAS SOBRE A TERAPIA DE REORIENTAÇÃO SEXUAL: UMA ANÁLISE À LUZ DO PRINCÍPIO DA DIGNIDADE HUMANA
Authors: Bolwerk Aloísio Alencar , De Almeida Lucas Andrade 
Published: October 2020

O presente artigo busca promover um estudo pormenorizado acerca das Terapias de Reorientação Sexual, numa perspectiva do Princípio da Dignidade Humana. Como princípio basilar do Estado Democrático de Direito, a dignidade da pessoa humana deve ser protegida e promovida, em suas diversas concepções e contextos. Assim, se mostrou necessária uma análise científica das Terapias de Reorientação Sexual – psicoterapias focadas na conversão da homossexualidade para a heterossexualidade. Isso porque a defesa de sua viabilidade e eficácia facilmente coincide com o ideal homofóbico e heteronormativo culturalmente vigente, e que trata a homossexualidade como patologia, como desvio, algo errado e anormal. Para fins de pesquisa e referencial teórico, foram usados trabalhos científicos desenvolvidos a respeito de temas correlatos. As pesquisas demonstraram que tanto a psicologia como a psiquiatria estabeleceram crítica às terapias reorientadoras, e reconheceram a homoafetividade como uma expressão natural da sexualidade, além de identificar o preconceito enraizado na sociedade como causa de grande parte dos transtornos mentais ligados à homossexualidade. A defesa da viabilidade dessas terapias, por conseguinte, se mostra exatamente como uma forma de perpetrar o preconceito homofóbico arraigado na sociedade, visto que suas fundamentações não tem base científica e ética, e possuem, como ponto de partida, a crença da homossexualidade como algo anormal/patológico. Essa discriminação em razão de orientação sexual constitui uma ofensa direta ao princípio da dignidade humana, que é o valor-fonte de todo o ordenamento jurídico pátrio.
PALEODICTYON IN SHALLOW-MARINE SETTINGS – AN EVALUATION BASED ON EOCENE EXAMPLES FROM IRAN
Authors: MALEKZADEH MOHAMMAD , WETZEL ANDREAS 
Published: October 2020

ABSTRACTThe graphoglyptid trace fossil Paleodictyon, characterized by stratiform hexagonal meshes, typically occurs preserved at the base of deep-marine turbidites. There is, however, a growing number of occurrences of Paleodictyon in shallow-marine deposits as evidenced by new finds in the Eocene of Iran. The Paleodictyon-containing Asara Shale Member of the Karaj Formation accumulated in a shallow backarc basin. Parallel-crested wave-ripple marks and microbially induced sedimentary structures occur closely above and below the Paleodictyon-bearing strata. Shallow-marine Paleodictyon have so far been reported from morphologically structured, extensive, epicontinental seas, rift basins, and young, prograding passive continental margins, but mainly from foreland and backarc basins. In the two latter cases, the Paleodictyon producers appear to represent adaptive survivors. Initially they settled in abyssal to bathyal turbiditic settings that rapidly aggraded and/or became tectonically uplifted with slight changes to depositional conditions. Finally, the Paleodictyon producers lived in rather shallow water and became preserved by tempestites. This scenario argues against the continuous presence of Paleodictyon producers in shallow-marine settings, suggesting instead they appeared there recurrently.
4P Model for Dynamic Prediction of the Covid-19: A Statistical and Machine Learning Approach
Authors: Hasan Khandaker Tabin , Rahman Mohammed Mostafizur , Ahmmed Md. Mortuza , Chowdhury Anjir Ahmed , Islam Mohammad Khairul 
Published: October 2020

Abstract
Introduction: Around the world, scientists are racing hard to understand how Covid-19 epidemic is spreading and growing, thus trying to find ways to prevent it before medications come to pass. Many different models have been proposed so far correlating different factors. Some of them are too localized to indicate a general trend of the pandemic while some others have established transient correlations only.Methods: Hence, in this study, a 4P model has been proposed based on four probabilities (4P) which has been found to be true for all affected countries taking Bangladesh as a case. Efficiency scores have been estimated from survey analysis not only for governing authorities on managing the situation (P(G)) but also for the compliance of the citizens ((P(P)). Since the immune responses of all the people are not uniform to a specific pathogen, the probability of a person getting infected ((P(I)) after being exposed has also been estimated. And the vital one is the probability of Test Positivity ((P(T)) which is a strong indicator of how effectively the infected people are diagnosed and isolated from the rest of the group that affects the rate of growth.Results and Conclusion: All the four parameters have been fitted in a non-linear exponential model that partly updates itself periodically with everyday facts. Along with the model, all the four probabilistic parameters are engaged to train a recurrent neural network using Long-Short Term Memory neural network and the followed trial confirmed a ruling functionality of the 4Ps.
The development and validation of a prognostic nomogram and nomogram application software among men treated with abiraterone acetate and/or enzalutamide for metastatic castration-resistant prostate cancer
Authors: Kawahara Takashi , Saigusa Yusuke , Yoneyama Shuko , Kato Masashi , Kojima Ippei , Yamada Hiroshi , Kamihira Osamu , Tabata Kenichi , Tsumura Hideyasu , Iwamura Masatsugu , Yao Masahiro , Uemura Hiroji , Miyoshi Yasuhide 
Published: October 2020

Abstract
BACKGROUND:With widespread medication choices for metastatic castration-resistant prostate cancer (mCRPC) is now available, on the other hand biomarker to predict the efficacy of each mCRPC treatment has not been established.Objective:This study developed prognostic nomogram to predict prognosis in CRPC patients who received abiraterone acetate (ABI) and/or enzalutamide (ENZ).Design, Setting, and Participants:A total of 568 mCRPC patients received ABI and/or ENZ from 2012 to 2017 were enrolled in this study. We developed prognostic nomogram based on the risk factors by Cox proportional hazards regression model.Outcome Measurements and Statistical Analysis:The nomogram was also assessed for discriminatory ability with the concordance index (C-index). We repeated 5-fold cross-validation 2000 times to estimate the C-index and reported the means of the estimated C-index for the training and validation sets. And we also developed nomogram application software (app) based on this nomogram.Results and Limitations:The median overall survival (OS) was 24.7 months. A multivariable analysis showed that the time to CRPC, pre-chemotherapy, baseline PSA, baseline ALP, and baseline LDH were independent risk factors for the OS (HR: 0.521, 1.681, 1.439, 1.827, 12,123, p:0.001, 0.001, <0.001, 0.019, <0.001)). C-index was 0.72 in training cohort and 0.71 in validation cohort.CONCLUSIONS:We developed nomograms to predict the OS for Japanese mCRPC patients who received ABI and/or ENZ. The advent of mCRPC prognosis prediction app will facilitate greater accessibility for clinical use.Patient SummaryThis study developed and validated a nomogram for predicting the prognosis of mCRPC patients who receive ABI/ENZ treatment using clinical information. This study also developed mobile app to facilitate clinical usage.
Structural and immunological characterization of an epitope within the PAN motif of ectodomain I in Babesia bovis apical membrane antigen 1
Authors: Rittipornlertrak Amarin , Nambooppha Boondarika , Muenthaisong Anucha , Punyapornwithaya Veerasak , Tiwananthagorn Saruda , Chung Yang-Tsung , Tuvshintulga Bumduuren , Sivakumar Thillaiampalam , Yokoyama Naoaki , Sthitmatee Nattawooti 
Published: October 2020

Abstract
Background

Bovine babesiosis caused by Babesia bovis (B. bovis) affects the cattle industry worldwide with high mobility and mortality. Live-attenuated vaccines are currently used in some of the endemic countries, but their wide use is limited due to various reasons. Although recombinant vaccines have been proposed as an alternative to the live vaccines, such vaccines are not commercially available to date. Apical membrane antigen-1 (AMA-1) is one of the leading candidates for vaccine development against diseases caused by apicomplexan parasite species. In this study, we predicted an epitope from the plasminogen, apple and nematode (PAN) motif of domain I in the B. bovis AMA-1 (BbAMA-1) using a combination of linear and conformational B-cell epitope prediction software. The selected epitope was bioinformatically analyzed, synthesized as a peptide (sBbAMA-1), and then used to immunize a rabbit.
Results

The anti-sBbAMA-1 serum obtained was evaluated for its growth- and invasion-inhibitory effects on B. bovis merozoites in vitro. Our results demonstrated that the predicted BbAMA-1 epitope, which is located on surface-exposed α-helix of PAN motif in domain I at the apex area, elicits antibodies capable of recognizing the native BbAMA-1 in immunoassays. Importantly, as compared to the control groups, the rabbit anti-sBbAMA-1 serum at dilution of 1:5 significantly inhibited (p < 0.05) the growth of B. bovis merozoites by approximately 50–70% on day 3 and 4 of cultivation and the invasion of merozoites by approximately 60% within 4 h of incubation.
Conclusion

Our results indicate the epitope predicted from the PAN motif of BbAMA-1 domain I is neutralization-sensitive and may serve as a target antigen for vaccine development against bovine babesiosis caused by B. bovis.
High Performance Voltage Tailorable Room-temperature Ca-metal Batteries
Authors: Song Huawei , Su Jian , Wang Chengxin 
Published: October 2020

Abstract
Calcium metal battery as one of the promising alternatives beyond Li-metal technology is challenged by the lack of suitable cathodes with considerable energy performance, and stable Ca anode of long-term stability and lower polorization potentials for Ca-plating/stripping. Here, by recycling cellulose waste paper of wide sources in our daily life, we develop feasible cathodes for Ca-metal batteries of good high-voltage and wide-window-voltage adaptability (0.005-4.9 V vs. Ca/Ca2+), except for considerable energy performance (~517.5 Wh kg-1 at 0.1 A g-1). Meanwhile, through tailorable Ca-plating/stripping potentials (∆V= ~0.65 V) induced by electrolyte modification, proof-of-concept Ca-metal batteries not only delivered enhanced storage capability (101 mAh g-1 vs. 51 mAh g-1 at 0.1 A g-1 in the window voltage of 2.0-4.7 V ) and cycling stability (~77% capacity retention for 100 cycles), but also simutaneously held high output average working voltage of ~3.2V.
Treatment of Anosmia and Ageusia in COVID-19 Patients by Using Coffee
Authors: Hosseini Asiyeh , Mirmehdi Esmaeil , Moghadam Mina Akbari 
Published: October 2020

Abstract
Introduction: The sudden onset of smell and taste loss has been reported as a symptom related to COVID-19. There is new evidence for the loss of smell and taste as a symptom of COVID-19 infection.Objectives: This study aims to examine influence of coffee on smell and taste of patients with Covid-19.Methods: In order to investigate the effect of coffee consumption on the taste and smell of COVID-19 patients, we attempted to sample in 20 provinces of the country, COVID-19 patients were separated by gender and underlying and non-underlying disease, doses of 15-20 mg for non-underlying patients and 25-30 mg for underlying patients. The reason for determining this amount of coffee is that every coffee we want to prepare needs a scoop of 14 grams of coffee, which we determine. For some people, it was determine 14 grams and for some people 28 grams of coffee was determined due to consumed in two cups of coffee.Results: Patients with Covid-19 had reversibility on the first and second day. It was clear that there is a small gap between the proportion of recovered patients in the underlying and non-underlying patients, but due to the high volume of observations, this small difference is evident.Conclusions: Anosmia and Ageusia is more prevalent in COVID-19 patients. Caffeine in coffee reduced the reversibility of the sense of smell and taste of people with Covid-19. It was concluded that the chances of recovery are higher for those who do not have the underlying disease than for the other groups and for those who suffer from all three types of the underlying disease than for the other groups.
Development and Validation of Prognostic Nomogram for Patients With Small Intestinal Neuroendocrine Carcinoma
Authors: Lu Guangrong , Wu Limin , Li Jiajia , Xia Yushan , Zhang Xuchao , Shi Yuning , Li Lili 
Published: October 2020

Abstract
Small intestinal neuroendocrine carcinomas (SI NECs) are diagnosed very rarely, and the prognosis is extremely poor due to the metastatic disease of most patients at the time of diagnosis. This study aimed to establish nomogram models for prognostic evaluation of SI NEC in both overall survival (OS) and cancer-specific survival (CSS). Patients diagnosed with SI NEC between 2010 and 2015 were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database and further randomly divided into the training and validating cohorts at a ratio of 7:3. Univariate and multivariate cox analysis was conducted to determine significant variables for construction of nomogram. The performance of the nomogram models were then assessed by concordance index (C-index), calibration plot and the area receiver operating characteristic (ROC) curve (AUC). A total of 1110 patients were retrospectively selected from the SEER database. Multivariate models revealed that age, tumor grade, American Joint Committee for Cancer (AJCC) stage, surgery and chemotherapy all showed a significant association with OS and CSS. The discrimination of nomogram for OS prediction was superior to that of the 7th AJCC Tumor-Node-Metastasis (TNM) staging system (C-index = 0.798, 95% CI, 0.762 - 0.833 vs 0.623, 95% CI, 0.580 - 0.666, P < 0.001). Similar results were also observed in CSS nomogram. Well-corresponded calibration plots were noticed using the nomograms. The comparisons of AUC values showed that the established nomograms exhibited better discrimination power than 7th TNM staging system for OS and CSS prediction. In conclusion, we have successfully established novel nomograms for predicting OS and CSS in patients with SI NEC, which can assist clinicians in making predictions about individual patient survival and provide improved treatment strategies.
Targeted DNA Methylation Analysis by High-Throughput Sequencing in Hepatic Carcinoma Tissue and Adjacent Normal Tissues
Authors: Zhang Guangmou , Feng Huigen , Yuan Zhiqing 
Published: October 2020

Abstract
Background: The relationship between epigenetic abnormalities and tumorigenesi has been investigated in the past decade and made major advances, particularly the abnormal expression of small RNAs, DNA methylation, and histone modification in cancer. In many tumor-related studies, the regulatory changes in DNA methylation during cancer development and the development of resistance to anticancer drugs have show that DNA methylation can be used as a biomarker for cancer diagnosis and concomitant diagnosis, but there is a lack of clinically useful biomarkers associated with hepatic carcinoma. Using high-throughput sequencing technology, appropriate testing and validation can be carried out in large samples. The relationship between DNA methylation and tumor development can be explored, contributing to clinical diagnosis and personalized treatment of hepatic carcinoma. Methods: In this study, we implemented and evaluated the effectiveness of high-throughput sequencing for DNA methylation analysis in hepatic carcinoma. For the relationship between DNA methylation and gene expression, Pearson correlation analysis was used to evaluate the correlation. Twenty-five isolated genomic regions were amplified by PCR using bisulfite-transformed liver cancer tissue (Ca) and paracancer tissue (T) as template DNA. PCR final product sequence information was obtained by sequence analysis using Illumina Hiseq/Miseq platform. Results: The average depth of coverage across all amplicons was 30,548 for T and 29,346 for Ca, with a maximum of 3,675 at the ARID1A amplicon and a minimum of 65 at the PTEN amplicon. Methylation spectra were obtained for each genomic locus of the two groups of samples, and the results showed that methylation was significantly different at the X target loci and slightly different at the Y target loci. Cluster analysis showed that all T tissues were clustered in one group (except tissues T2 and T3), while Ca tissues were clustered on the other side. The results showed that DNA methylation at the loci may be closely related to liver cancer, providing references for the research and development of biomarkers in clinical diagnosis. Conclusions: The study demonstrates that high-throughput sequencing technology is a powerful and cost-effective method for methylation analysis of target DNA in cancer tissues.