bluuebunny/crossref_metadata_2025_split huggingface dataset:
An assessment of rapamycin for weakening binge-eating memories via reconsolidation: a pre-registered, double-blind randomised placebo-controlled experimental study
Authors: Walsh Katie , Iskandar Georges , Kamboj Sunjeev K. , Das Ravi K. 
Published: November 2019

AbstractBackgroundMaladaptive learning linking environmental food cues to high-palatability food reward plays a central role in overconsumption in obesity and binge eating disorders. The process of memory reconsolidation offers a mechanism to weaken such learning, potentially ameliorating over-eating behaviour. Here we investigated whether putatively interfering with synaptic plasticity using the mammalian target of rapamycin (mTOR) inhibitor, rapamycin, could weaken retrieved chocolate reward memories through blockade of reconsolidationMethodsSeventy five healthy volunteers with a tendency to binge eat chocolate were randomised to retrieve chocolate reward memory under 10 mg rapamycin (RET + RAP, active condition), or placebo (RET + PBO), or they received 10 mg rapamycin without subsequent retrieval (NO RET + RAP). Indices of chocolate reward memory strength were assessed one week pre and post manipulation and at one month follow-up.ResultsContrary to hypotheses, the RET + RAP group did not show any greater reduction than control groups on indices of motivational salience of chocolate cues, motivation to consume chocolate or liking of chocolate. Mild evidence of improvement in the RET + RAP group was found, but this was limited to reduced chocolate binge episodes and improved healthy food choices.ConclusionsWe did not find convincing evidence of comprehensive naturalistic chocolate reward memory reconsolidation blockade by rapamycin. The effects on chocolate bingeing and food choices may warrant further investigation. These limited positive findings may be attributable to insufficient interference with mTOR signalling with 10 mg rapamycin, or failure to destabilise chocolate memories during retrieval.
Dissecting the functional outcomes of first episode schizophrenia spectrum disorders: a 10-year follow-up study in the PAFIP cohort
Authors: Ayesa-Arriola Rosa , Ortíz-García de la Foz Víctor , Martínez-García Obdulia , Setién-Suero Esther , Ramírez María Luz , Suárez-Pinilla Paula , Mayoral-van Son Jacqueline , Vázquez-Bourgon Javier , Juncal-Ruiz María , Gómez-Revuelta Marcos , Tordesillas-Gutiérrez Diana , Crespo-Facorro Benedicto 
Published: November 2019

AbstractBackgroundThe aim of the current study was to examine the heterogeneity of functional outcomes in first episode psychosis (FEP) patients and related clinical, neurocognitive and sociodemographic factors using a cluster analytic approach.MethodA large sample of FEP patients (N = 209) was functionally reassessed 10 years after the first contact with an early intervention service. Multiple baseline, 3-year and 10-year follow-up variables were explored.ResultsThe cluster analysis emphasized the existence of six independent clusters of functioning: one cluster was normal overall (42.16%), two clusters showed moderate interpersonal (9.63%) or instrumental (12.65%) deficits, two clusters showed more severe interpersonal (12.05%) or interpersonal and instrumental (13.85%) deficits and there was a significantly overall impaired cluster (9.63%). Cluster comparisons showed that several baseline and follow-up factors were differentially involved in functional outcomes.ConclusionsThe current study demonstrated that distinct clusters of functioning in FEP patients can be identified. The fact that a variety of profiles was observed contributes to a better understanding of the nature of the heterogeneity characterizing FEP patients and has clinical implications for developing individualized treatment plans.
Parietal P3 and midfrontal theta prospectively predict the development of adolescent alcohol use
Authors: Harper Jeremy , Malone Stephen M. , Iacono William G. 
Published: November 2019

AbstractBackgroundSubclinical adolescent alcohol use is highly prevalent and may have deleterious effects on important psychosocial and brain outcomes. Prior research has focused on identifying endophenotypes of pathological drinking, and the predictors of normative drinking remain understudied. This study investigated the incremental predictive value of two potential psychophysiological endophenotypes, P3 amplitude (an index of decision making) and midfrontal theta power (a correlate of attentional control), for prospectively predicting the expression and initiation of alcohol use emerging in adolescence.MethodsA large (N= 594) epidemiological sample was prospectively assessed at ages 11/14/17. Alcohol/substance use was assessed at all ages via a computerized self-report inventory. EEG was recorded at age-14 during a visual oddball task to elicit P3 and theta.ResultsReduced target-related P3 and theta at age-14 prospectively predicted drinking at age-17 independent of one another. Among alcohol-naive individuals at age-14, attenuated P3 and theta increased the odds of new-onset alcohol behaviors 3 years later. Importantly, the endophenotypes provided significant incremental predictive power of future non-clinical alcohol use beyond relevant risk factors (prior alcohol use; tobacco/illicit drug initiation; parental alcohol use disorder).ConclusionsThe current report is the first of our knowledge to demonstrate that deviations in parietal P3 and midfrontal theta prospectively predict the emergence of normative/non-pathological drinking. P3 and theta provide modest yet significant explanatory variance beyond prominent self-report and familial risk measures. Findings offer strong evidence supporting the predictive utility of P3 and theta as candidate endophenotypes for adolescent drinking.
Social connectedness: what matters to older people?
Authors: Morgan Tessa , Wiles Janine , Park Hong-Jae , Moeke-Maxwell Tess , Dewes Ofa , Black Stella , Williams Lisa , Gott Merryn 
Published: November 2019

AbstractWhile social connectedness is heralded as a key enabler of positive health and social outcomes for older people, rarely have they themselves had the opportunity to express their views about the concept. Working with a diverse group of Pacific, Māori, Asian and New Zealand European older adults, this paper explores what matters to older people when discussing social connectedness? We draw from individual, in-depth interviews with 44 older adults, and three group interviews comprising 32 older adults. Data were analysed using thematic and narrative analyses. The three themes identified were: getting out of the house, ability to connect and feelings of burden. Fundamental to social connectedness was participants’ desire to be recognised as resourceful agents able to foster relationships on the basis of mutual respect. Social connectedness was conceptualised as multi-levelled: relating to interpersonal relationships as much as neighbourhoods and wider society. Alongside these similarities we also discuss important differences. Participants preferred to socialise with people from similar cultural backgrounds where they shared taken-for-granted social customs and knowledges. This is in the context where racism, poverty and inequalities clearly impeded already minoritised participants’ sense of social connection. Key structural ways to improve social connectedness should focus on factors that enable cohesion between levels of connection, including stable neighbourhoods serviced with accessible public transport, liveable pensions and inclusivity of cultural diversity.
First Nations Elders Who Use Wheeled Mobility: An Exploration of Culture and Health
Authors: Croxall Lindsay , Gifford Wendy , Jutai Jeffrey 
Published: November 2019

RÉSUMÉUne recherche interdisciplinaire faisant appel à des méthodes qualitatives a été menée pour étudier les obstacles et les facilitateurs relatifs à la participation culturelle des aînés des Premières Nations qui utilisent la mobilité sur roues et vivent dans des réserves en Ontario (Canada). Les thèmes ont été divisés en trois grandes catégories : (1) l’impact de la participation des aînés à des activités culturelles, (2) l’utilité des aides à la mobilité sur roues et (3) les obstacles freinant la participation à des événements culturels. Les obstacles incluent le manque de transports, l’incapacité de sortir du domicile en toute sécurité et de manière indépendante, l’irrégularité du terrain des réserves ; la stigmatisation associée au handicap, et le sentiment d’être un fardeau. Les résultats suggèrent que la mobilité sur roues peut augmenter la participation active des aînés aux événements culturels, mais démontrent aussi la nécessité de faciliter l’utilisation de cette mobilité dans les réserves en Ontario.
Maternal alcohol dependence and harsh caregiving across parenting contexts: The moderating role of child negative emotionality
Authors: Jacques Debrielle T. , Sturge-Apple Melissa L. , Davies Patrick T. , Cicchetti Dante 
Published: November 2019

AbstractParental alcohol dependence is a significant risk factor for harsh caregiving behaviors; however, it is unknown whether and how harsh caregiving changes over time and across parenting contexts for alcohol-dependent mothers. Furthermore, to our knowledge, no studies have examined whether and how distinct dimensions of child characteristics, such as negative emotionality modulate harsh caregiving among alcohol-dependent mothers. Guided by parenting process models, the present study examined how two distinct domains of children's negative emotionality—fear and frustration—moderate the association between maternal alcohol dependence and maternal harshness across discipline and free-play contexts. A high-risk sample of 201 mothers and their two-year-old children were studied over a one-year period. Results from latent difference score analyses indicated that harsh parenting among alcohol-dependent mothers increased over time in the more stressful discipline context, but not in the parent–child play context. This effect was maintained even after controlling for other parenting risk factors, including other forms of maternal psychopathology. Furthermore, this increase in harsh parenting was specific to alcohol-dependent mothers whose children were displaying high levels of anger and frustration. Findings provide support for specificity in conceptualizations of child negative emotionality and parenting contexts as potential determinants of maladaptive caregiving among alcohol-dependent mothers.
Gradual session types
Authors: IGARASHI ATSUSHI , THIEMANN PETER , TSUDA YUYA , VASCONCELOS VASCO T. , WADLER PHILIP 
Published: November 2019

AbstractSession types are a rich type discipline, based on linear types, that lifts the sort of safety claims that come with type systems to communications. However, web-based applications and microservices are often written in a mix of languages, with type disciplines in a spectrum between static and dynamic typing. Gradual session types address this mixed setting by providing a framework which grants seamless transition between statically typed handling of sessions and any required degree of dynamic typing. We propose Gradual GV as a gradually typed extension of the functional session type system GV. Following a standard framework of gradual typing, Gradual GV consists of an external language, which relaxes the type system of GV using dynamic types; an internal language with casts, for which operational semantics is given; and a cast-insertion translation from the former to the latter. We demonstrate type and communication safety as well as blame safety, thus extending previous results to functional languages with session-based communication. The interplay of linearity and dynamic types requires a novel approach to specifying the dynamics of the language.
Culture of goat preantral follicles in situ associated with mesenchymal stem cell from bone marrow
Authors: Arrivabene Neves Camila , dos Santos Silva Lucilene , de Carvalho Camila Ernanda Sousa , Silva Carvalho Marina , Sarmento José Lindenberg Rocha , Vasconcelos Cavalcante Tânia , Arrivabene Mônica , Arrivabene Neves Tábatta , de Sousa Bezerra Maria Éllida , Júnior Antônio Luiz Gomes , da Silva Cleidson Manoel Gomes , de Carvalho Maria Acelina Martins 
Published: November 2019

SummaryThis study aims to develop an in vitro co-culture system of in situ goat preantral follicles with bone marrow-derived mesenchymal stem cells (BM-MSC), evaluating the influence of these cells on follicular growth, rate of activation and morphologically normal follicles. Fragments of ovarian cortex were cultured for 1 or 7 days in the presence of BM-MSC (BM-MSC+) and absence of BM-MSC (BM-MSC−). Histological sections of the fragments were analysed and data were obtained regarding morphological classification, survival rate of morphologically normal follicles and rate of follicular activation. Culture medium on days 1 and 7 was also sampled for nitrite concentration and reduced glutathione activity. There was a reduction (P < 0.05) in the percentage of morphologically normal follicles in the BM-MSC+ compared with the fresh control only on the seventh day of culture. When comparing treatments, on the seventh day of culture, a higher rate of morphologically normal preantral follicles was observed in BM-MSC+ (P < 0.05). In both treatments, primordial and developing follicle rates were similar to the fresh control (P > 0.05). When comparing treatments with each other, as well as with the fresh control, no differences were observed in follicular diameter (P > 0.05) or nitrite concentration (P > 0.05). The concentration of reduced glutathione was lower on the seventh day of co-culture in both treatments (P < 0.05). In conclusion, co-culture had no influence on follicular or oocyte development. However, it was critical to maintain the survival of preantral follicles during 7 days of culture.
Nutrition care by primary-care physicians: advancing our understanding using the COM-B framework
Authors: Crowley Jennifer , Ball Lauren , Hiddink Gerrit J 
Published: November 2019

AbstractObjective:To investigate the nutrition education provided by primary-care physicians (PCP).Design:An integrative review was used to examine literature on nutrition care provided by PCP from 2012 to 2018. A literature search was conducted in MEDLINE, PubMed, Cumulative Index of Nursing and Allied Health Literature (CINAHL) and Scopus using key search terms.Setting:USA, Netherlands, Germany, Denmark, UK, Lebanon, Australia and New Zealand.Participants:Primary-care physicians.Results:Sixteen qualitative and quantitative studies were analysed thematically using meta-synthesis informed by the COM-B model of behaviour (capability, motivation and opportunity), to understand the influences on PCP behaviours to provide nutrition care. PCP perceive that they lack nutrition capability. While PCP motivation to provide nutrition care differs based on patient characteristics and those of their own, opportunity is influenced by medical educators, mentors and policy generated by professional and governmental organisations.Conclusions:The development of PCP capability, motivation and opportunity to provide nutrition care should begin in undergraduate medical training, and continue into PCP training, to create synergy between these behaviours for PCP to become confident providing nutrition care as an integral component of disease prevention and management in contemporary medical practice.
Does physical activity attenuate the association between birth weight and glycated hemoglobin in nondiabetic Japanese women?
Authors: Aoyama Tomoko , Miyatake Nobuyuki , Seki Akiho , Hossaka Kouji , Takimoto Hidemi , Tanaka Shigeho 
Published: November 2019

AbstractLower birth weight is associated with a risk of type 2 diabetes in adulthood. However, it is not clear whether this association is modified by physical activity. This study aimed to examine the association between birth weight and glycemic status and whether this association is mediated by moderate- and vigorous-intensity activity (MVPA) in Japanese women. The participants were 103 nondiabetic women (47.4 ± 10.8 years), who underwent health checkups in which data of glycated hemoglobin (HbA1c) were collected. Abdominal circumference (AC) was measured at the umbilical region. Birth weight was obtained from the Maternal and Child Health Handbook records or reported based on the participant’s or his/her mother’s recall. Time (min/day) spent in MVPA (≥3.0 metabolic equivalents) was objectively measured using a triaxial accelerometer (Actimarker EW4800). Birth weight was inversely correlated with HbA1c (r = −0.32, P < 0.01). Multiple linear regression analyses revealed that lower birth weight was associated with increased HbA1c (β = −0.22, P < 0.05) even after adjusting for age, state of menstruation, AC, and family history of diabetes. This association was little changed when MVPA was introduced as an independent variable in the model (β = −0.23, P < 0.05). These results suggest that lower birth weight may be associated with higher HbA1c levels before the onset of type 2 diabetes, irrespective of adulthood physical activity. Early-life development should be taken into account when considering the risk of diabetes in Japanese women, even if they are physically active.
Herbicide selection to terminate grass, legume, and brassica cover crop species
Authors: Pittman Kara B. , Cahoon Charles W. , Bamber Kevin W. , Rector Lucas S. , Flessner Michael L. 
Published: November 2019

AbstractCover crops provide a number of agronomic benefits, including weed suppression, which is important as cases of herbicide resistance continue to rise. To effectively suppress weeds, high cover crop biomass is needed, which necessitates later termination timing. Cover crop termination is important to mitigate potential planting issues and prevent surviving cover crop competition with cash crops. Field studies were conducted in Virginia to determine the most effective herbicide options alone or combined with glyphosate or paraquat to terminate a range of cover crop species. Results revealed that grass cover crop species were controlled (94% to 98%) by glyphosate alone 4 wk after application (WAA). Overall, legume species varied in response to the single active-ingredient treatments, and control increased with the addition of glyphosate or paraquat. Mixes with glyphosate provided better control of crimson clover and hairy vetch by 7% to 8% compared with mixes containing paraquat 4 WAA. Mix partner did not influence control of Austrian winter pea. No treatment adequately controlled rapeseed in this study, with a maximum of 58% control observed with single active-ingredient treatments and 62% control with mixes. Height reduction for all cover crop species supports visible rating data. Rapeseed should be terminated when smaller, which could negate weed suppressive benefits from this cover crop species. Growers should consider herbicide selection and termination timing in their cover crop plan to ensure effective termination.
Asian and Trans‐Pacific Dust: A Multimodel and Multiremote Sensing Observation Analysis
Authors: Kim Dongchul , Chin Mian , Yu Hongbin , Pan Xiaohua , Bian Huisheng , Tan Qian , Kahn Ralph A. , Tsigaridis Kostas , Bauer Susanne E. , Takemura Toshihiko , Pozzoli Luca , Bellouin Nicolas , Schulz Michael 
Published: November 2019

AbstractDust is one of the dominant aerosol types over Asia and the North Pacific Ocean, but quantitative estimation of dust distribution and its contribution to the total regional aerosol load from observations is challenging due to the presence of significant anthropogenic and natural aerosols and the frequent influence of clouds over the region. This study presents the dust aerosol distributions over Asia and the North Pacific using simulations from five global models that participated in the AeroCom phase II model experiments, and from multiple satellite remote sensing and ground‐based measurements of total aerosol optical depth and dust optical depth. We examine various aspects of aerosol and dust presence in our study domain: (1) the horizontal distribution, (2) the longitudinal gradient during trans‐Pacific transport, (3) seasonal variations, (4) vertical profiles, and (5) model‐simulated dust life cycles. This study reveals that dust optical depth model diversity is driven mostly by diversity in the dust source strength, followed by residence time and mass extinction efficiency.
The Role of the Stratosphere in Subseasonal to Seasonal Prediction: 2. Predictability Arising From Stratosphere‐Troposphere Coupling
Authors: Domeisen Daniela I. V. , Butler Amy H. , Charlton‐Perez Andrew J. , Ayarzagüena Blanca , Baldwin Mark P. , Dunn‐Sigouin Etienne , Furtado Jason C. , Garfinkel Chaim I. , Hitchcock Peter , Karpechko Alexey Yu. , Kim Hera , Knight Jeff , Lang Andrea L. , Lim Eun‐Pa , Marshall Andrew , Roff Greg , Schwartz Chen , Simpson Isla R. , Son Seok‐Woo , Taguchi Masakazu 
Published: November 2019

AbstractThe stratosphere can have a significant impact on winter surface weather on subseasonal to seasonal (S2S) timescales. This study evaluates the ability of current operational S2S prediction systems to capture two important links between the stratosphere and troposphere: (1) changes in probabilistic prediction skill in the extratropical stratosphere by precursors in the tropics and the extratropical troposphere and (2) changes in surface predictability in the extratropics after stratospheric weak and strong vortex events. Probabilistic skill exists for stratospheric events when including extratropical tropospheric precursors over the North Pacific and Eurasia, though only a limited set of models captures the Eurasian precursors. Tropical teleconnections such as the Madden‐Julian Oscillation, the Quasi‐Biennial Oscillation, and El Niño–Southern Oscillation increase the probabilistic skill of the polar vortex strength, though these are only captured by a limited set of models. At the surface, predictability is increased over the United States, Russia, and the Middle East for weak vortex events, but not for Europe, and the change in predictability is smaller for strong vortex events for all prediction systems. Prediction systems with poorly resolved stratospheric processes represent this skill to a lesser degree. Altogether, the analyses indicate that correctly simulating stratospheric variability and stratosphere‐troposphere dynamical coupling are critical elements for skillful S2S wintertime predictions.