bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence of and Risk Factors for Systemic Adverse Events After Screening or Primary Diagnostic Colonoscopy: A Nationwide Cohort Study
Authors: Laanani Moussa , Weill Alain , Carbonnel Franck , Pouchot Jacques , Coste Joël 
Published: March 2020

OBJECTIVES:
To estimate the systemic serious adverse event (SAE) rates after colonoscopy and to identify their risk factors.

METHODS:
A nationwide cohort study was conducted using the comprehensive French claims databases SNDS (National Health Data System). Patients aged 30 years and over who underwent a first screening or diagnostic colonoscopy in 2010–2015 were included. The rates of cardiovascular and renal SAEs were estimated within 5 days after colonoscopy. The standardized incidence ratios were calculated to compare these incidence rates with those of the same events in the general population, and the associated risk factors were assessed by multilevel logistic regression.

RESULTS:
Among the 4,088,799 included patients (median age, 59 years [interquartile range = 50–67]; 55.2% women; 30.1% with a Charlson index score ≤1), the 5-day SAE incidence rate was 2.8/10,000 procedures for shock, 0.87/10,000 for myocardial infarction, 1.9/10,000 for stroke, 2.9/10,000 for pulmonary embolism, 5.5/10,000 for acute renal failure, and 3.3/10,000 for urolithiasis. These SAEs occurred 3.3 to 15.8 times more often during the first 5 days after colonoscopy than expected in the general population. Thirty-day mortality rates ranged from 2.2/1,000 cases of urolithiasis to 268.1/1,000 cases of shock. Increasing age was associated with an increasing incidence of SAEs. Risks of shock and acute renal failure were associated with a greater number of comorbidities than the other SAEs. Colonoscopies in university hospitals were associated with higher risks, reflecting patient selection processes.

DISCUSSION:
The systemic SAEs can be associated with a substantial mortality. They should be taken into account when deciding colonoscopy, in addition to perforation and bleeding, particularly in elderly patients with multiple comorbidities.
Positive Hepatitis B Core Antibody Is Associated With Cirrhosis and Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease
Authors: Chan Ting Ting , Chan Wah Kheong , Wong Grace Lai-Hung , Chan Anthony Wing-Hung , Nik Mustapha Nik Raihan , Chan Stephen Lam , Chong Charing Ching-Ning , Mahadeva Sanjiv , Shu Sally She-Ting , Lai Paul Bo-San , Chan Henry Lik-Yuen , Wong Vincent Wai-Sun 
Published: March 2020

OBJECTIVES:
Previous exposure to hepatitis B virus (HBV) may increase the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis C. We aim to study the impact of previous HBV infection on the severity and outcomes of patients with nonalcoholic fatty liver disease (NAFLD).

METHODS:
This was a multicenter study of 489 patients with biopsy-proven NAFLD and 69 patients with NAFLD-related or cryptogenic HCC. Antihepatitis B core antibody (anti-HBc) was used to detect the previous HBV infection.

RESULTS:
In the biopsy cohort, positive anti-HBc was associated with lower steatosis grade but higher fibrosis stage. 18.8% and 7.5% of patients with positive and negative anti-HBc had cirrhosis, respectively (P < 0.001). The association between anti-HBc and cirrhosis remained significant after adjusting for age and metabolic factors (adjusted odds ratio 2.232; 95% confidence interval, 1.202–4.147). At a mean follow-up of 6.2 years, patients with positive anti-HBc had a higher incidence of HCC or cirrhotic complications (6.5% vs 2.2%; P = 0.039). Among patients with NAFLD-related or cryptogenic HCC, 73.9% had positive anti-HBc. None of the patients had positive serum HBV DNA. By contrast, antihepatitis B surface antibody did not correlate with histological severity.

DISCUSSION:
Positive anti-HBc is associated with cirrhosis and possibly HCC and cirrhotic complications in patients with NAFLD. Because a significant proportion of NAFLD-related HCC may develop in noncirrhotic patients, future studies should define the role of anti-HBc in selecting noncirrhotic patients with NAFLD for HCC surveillance.
Acute Effect of High-Intensity Interval Versus Moderate-Intensity Continuous Exercise on Blood Pressure and Arterial Compliance in Middle-Aged and Older Hypertensive Women With Increased Arterial Stiffness
Authors: Costa Eduardo C. , Kent David E. , Boreskie Kevin F. , Hay Jacqueline L. , Kehler Dustin S. , Edye-Mazowita Alex , Nugent Kristina , Papadopoulos Josaphine , Stammers Andrew N. , Oldfield Chris , Arora Rakesh C. , Browne Rodrigo A.V. , Duhamel Todd A. 
Published: March 2020

Abstract
Costa, EC, Kent, DE, Boreskie, KF, Hay, JL, Kehler, DS, Edye-Mazowita, A, Nugent, K, Papadopoulos, J, Stammers, AN, Oldfield, C, Arora, RC, Browne, RAV, and Duhamel, TA. Acute effect of high-intensity interval versus moderate-intensity continuous exercise on blood pressure and arterial compliance in middle-aged and older hypertensive women with increased arterial stiffness. J Strength Cond Res 34(5): 1307–1316, 2020—Hypertension and arterial stiffness are common in middle-aged and older women. This study compared the acute effect of high-intensity interval exercise (HIIE) and moderate-intensity continuous exercise (MICE) on blood pressure (BP) and arterial compliance in middle-aged and older hypertensive women with increased arterial stiffness. Nineteen women (67.6 ± 4.7 years) participated in this randomized controlled crossover trial. Subjects completed a control, MICE (30 minutes at 50–55% of heart rate reserve [HRR]), and HIIE (10 × 1 minute at 80–85% of HRR, 2 minutes at 40–45% of HRR) session in random order. Blood pressure and large and small arterial compliance (radial artery pulse wave analysis) were measured at baseline and 30, 60, 90, and 120 minutes after sessions. A p < 0.05 was considered statistically significant. Systolic BP was reduced in ∼10 mm Hg after MICE at 30 minutes and after HIIE at all time points (30, 60, 90, and 120 minutes) after exercise compared with the control session (p < 0.05). Only HIIE showed lower systolic BP levels at 60, 90, and 120 minutes after exercise compared with the control session (∼10 mm Hg; p < 0.05). No changes were observed in diastolic BP, or in large and small arterial compliance (p > 0.05). High-intensity interval exercise elicited a longer systolic postexercise hypotension than MICE compared with the control condition, despite the absence of acute modifications in large and small arterial compliance.
Neural Isolation of the Olfactory Bulbs Severely Impairs Taste-Guided Behavior to Normally Preferred, But Not Avoided, Stimuli
Authors: Inui-Yamamoto Chizuko , Blonde Ginger D. , Schmid Fabienne , Mariotti Lauren , Campora Matias , Inui Tadashi , Schier Lindsey A. , Spector Alan C. 
Published: March 2020

AbstractHere we systematically tested the hypothesis that motivated behavioral responsiveness to preferred and avoided taste compounds is relatively independent of the olfactory system in mice whose olfactory bulbs (main and accessory) were surgically disconnected from the rest of the brain [bulbotomy (BULBx)]. BULBx was confirmed histologically as well as functionally with the buried food test. In brief access taste tests, animals received 10-s trials of various concentrations of a taste compound delivered quasirandomly. BULBx C57BL/6 (B6) mice displayed severely blunted concentration-dependent licking for the disaccharide sucrose, the maltodextrin Maltrin, and the fat emulsion Intralipid relative to their sham-operated controls (SHAM B6). Licking for the noncaloric sweetener saccharin was also blunted by bulbotomy, but less so. As expected, mice lacking a functional “sweet” receptor [T1R2+T1R3 knockout (KO)] displayed concentration-dependent responsiveness to Maltrin and severely attenuated licking to sucrose. Like in B6 mice, responsiveness to both stimuli was exceptionally curtailed by bulbotomy. In contrast to these deficits in taste-guided behavior for unconditionally preferred stimuli, BULBx in B6 and KO mice did not alter concentration-dependent decreases for the representative avoided stimuli quinine and citric acid. Nor did it temper the intake of and preference for high concentrations of affectively positive stimuli when presented in long-term (23-h) two-bottle tests, demonstrating that the surgery does not lead to a generalized motivational deficit. Collectively, these behavioral results demonstrate that specific aspects of taste-guided ingestive motivation are profoundly disturbed by eliminating the anatomic connections between the main/accessory olfactory bulbs and the rest of the brain.
Prohibitin S-Nitrosylation Is Required for the Neuroprotective Effect of Nitric Oxide in Neuronal Cultures
Authors: Qu Youyang , Konrad Csaba , Anderson Corey , Qian Liping , Yin Tina , Manfredi Giovanni , Iadecola Costantino , Zhou Ping 
Published: March 2020

Prohibitin (PHB) is a critical protein involved in many cellular activities. In brain, PHB resides in mitochondria, where it forms a large protein complex with PHB2 in the inner TFmembrane, which serves as a scaffolding platform for proteins involved in mitochondrial structural and functional integrity. PHB overexpression at moderate levels provides neuroprotection in experimental brain injury models. In addition, PHB expression is involved in ischemic preconditioning, as its expression is enhanced in preconditioning paradigms. However, the mechanisms of PHB functional regulation are still unknown. Observations that nitric oxide (NO) plays a key role in ischemia preconditioning compelled us to postulate that the neuroprotective effect of PHB could be regulated by NO. Here, we test this hypothesis in a neuronal model of ischemia–reperfusion injury and show that NO and PHB are mutually required for neuronal resilience against oxygen and glucose deprivation stress. Further, we demonstrate that NO post-translationally modifies PHB through protein S-nitrosylation and regulates PHB neuroprotective function, in a nitric oxide synthase-dependent manner. These results uncover the mechanisms of a previously unrecognized form of molecular regulation of PHB that underlies its neuroprotective function.SIGNIFICANCE STATEMENTProhibitin (PHB) is a critical mitochondrial protein that exerts a potent neuroprotective effect when mildly upregulated in mice. However, how the neuroprotective function of PHB is regulated is still unknown. Here, we demonstrate a novel regulatory mechanism for PHB that involves nitric oxide (NO) and shows that PHB and NO interact directly, resulting in protein S-nitrosylation on residue Cys69of PHB. We further show that nitrosylation of PHB may be essential for its ability to preserve neuronal viability under hypoxic stress. Thus, our study reveals a previously unknown mechanism of functional regulation of PHB that has potential therapeutic implications for neurologic disorders.
Análisis de las necesidades y uso de servicios de atención en salud mental en Colombia
Authors: Zamora-Rondón Diana Carolina , Suarez-Acevedo Daniel Enrique , Bernal-Acevedo Oscar Alberto 
Published: March 2020

Objetivo Analizar la relación existente entre la necesidad de atención y el uso de los servicios de salud mental en ColombiaMetodología Se comparó la prevalencia de trastornos mentales según la Encuesta Nacional de Salud Mental (ENSM-2015) y el registro de pacientes atendidos con diagnóstico de trastorno mental o del comportamiento en el Sistema Integral de Información (SISPRO-2013) la cual contiene los registros individuales de prestación de servicios de salud (RIPS) de todas las personas que acudieron al sistema de salud en un año.Resultados La prevalencia de enfermedades mentales estimada según la ENSM para la población colombiana mayor de siete años fue de 4,02% y la prevalencia de atención obtenida del SISPRO fue de 1,56%. Esto indica que el porcentaje de población que no está recibiendo atención en el sistema de salud es del 61,1%. De 1 695 726 personas con trastorno mental tan solo se atiende el 38,9%.Conclusiones La mayoría de las personas con trastornos mentales en el país no reciben atención en el sistema de salud.
Percepción de felicidad relacionada con la familia a lo largo de la vida en Bogotá, Colombia
Authors: González-Quiñones Juan Carlos , Restrepo-Chavarriaga Guillermo León , Pinzón-Ramírez Jenny Alexandra , Mejía de Díaz María Arnolda , Ayala Méndez Camilo 
Published: March 2020

Objetivo Demostrar la relación entre felicidad y funcionalidad familiar con el fin de promover las relaciones familiares y, con ello, la salud biopsicosocial.Materiales y Metodos Estudio descriptivo transversal. A lo largo de tres años se aplicó un cuestionario a 8 885 personas de Bogotá, escogidas por conveniencia. Se dividió la población entre los que afirmaron estar felices y quienes dijeron sentirse tristes al momento de realizar la encuesta. Como variables explicativas se indagaron el género, la edad, el estrato, la funcionalidad (usando el APGAR familiar) y la estructura familiar (miembros con los que se convive) y la red de apoyo. Se obtuvieron los Odss Ratio y los resultados significativos se sometieron al proceso de regresión.Resultados El análisis de regresión logística de las razones de riesgo mostró que la percepción de felicidad disminuye con la edad (60 y más años versus 7 a 10 años, OR 0,09 IC95% 0,03-0,26); que hay una asociación significativa más fuerte con la funcionalidad (disfunción severa versus funcionalidad normal, OR 0,05 IC95% 0,03-0,08) que con la estructura familiar (hogar extenso versus nuclear, OR 0,60 IC95% 0,37-0,96) y que la felicidad se relaciona con las redes de apoyo (red baja versus red alta, OR 0,52 IC95% 0,31-0,88).Conclusión Está investigación confirma la importancia de la familia en la percepción de la felicidad, sentimiento considerado como referente de salud. Con base en esto, resulta clave fortalecer la convivencia familiar para promover la salud de las personas.
ECO INOVAÇÃO: ESTUDOS NAS BASES WEB OF SCIENCE E SCOPUS E TENDÊNCIAS PARA PESQUISAS FUTURAS ## ECO-INNOVATION: STUDIES IN THE WEB OF SCIENCE AND SCOPUS BASES AND TRENDS FOR FUTURE RESEARCH
Authors: Pereira Michele Morais Oliveira , Prado José Willer do , Antunes Luiz Guilherme Rodrigues , Antonialli Luiz Marcelo , Tonelli Dany Flávio 
Published: March 2020

As inovações que trazem benefícios ao meio ambiente, mesmo que este efeito não tenha sido o principal objetivo da inovação, têm sido denominadas pela literatura como inovações ambientais, inovações verdes, eco inovações ou inovações sustentáveis. Este estudo teve como objetivo identificar e descrever como está configurado o campo de pesquisa sobre eco inovação e traçar uma agenda de estudos futuros sobre o tema. Realizou-se um levantamento de artigos indexados na base de dados Web of Science e Scopus (Elsevier) e, posteriormente, um estudo bibliométrico e elaboração de proposições para estudos futuros. Identificou-se os trabalhos mais relevantes no campo de estudo, os principais autores, periódicos e países mais proficuos, além das redes de relações entre pesquisadores. A partir da análise dos estudos empíricos mais citados, evidenciou-se relação positiva entre investimentos em eco inovação com a melhoria do desempenho das empresas, obtenção de vantagem competitiva e melhoria da imagem das mesmas frentes a seus consumidores. Quanto à agenda de estudos futuros, são recomendados estudos longitudinais, estudos comparativos, análises sobre implicações das eco inovações no desempenho organizacional, de pesquisas considerando-se as diferenças de desenvolvimento econômico dos países onde as empresas atuam e de estudos em pequenas e médias empresas.
O Início de Prova Material Para o Segurado Especial na Fusão de Horizontes de Sentido de Hans Georg-Gadamer
Authors: Generoso Costa Carlos Henrique 
Published: March 2020

O estudo trata sobre o segurado especial com base na legislação, doutrina e jurisprudência dos tribunais, além de demonstrar que a coleta de provas documentais se mostra dificultosa para tal segurado. Identifica-se na teoria do alemão Hans Georg-Gadamer a fusão de horizontes de sentido que providencia a ligação entre provas documentais e testemunhais. Traz o importante papel dos envolvidos na relação processual na busca pela verdade através das provas, sendo que tal episódio ensejará a procedência do pedido com a concessão do benefício de um salário mínimo para o segurado especial. Palavras-chave: Segurado Especial. Hans Georg-Gadamer. Prova Material. Testemunhas. AbstractThe study is initiated on the special insured based on the legislation, doctrine and jurisprudence of the courts, in addition to demonstrating that the collection of documentary evidence proves difficult for such insured. It is identified in the theory of the German Hans Georg-Gadamer the fusion of horizons of meaning that provides the link between documentary evidence and witnesses. It brings the important role of those involved in the procedural relationship in the search for truth through evidence, and such an episode will lead to the application being granted by granting the benefit of a minimum wage for the special insured. Keywords: Special Insured. Hans Georg-Gadamer. Material Proof . Witnesses.
Análise dos Critérios para se Definir o Dies a Quo dos Prazos Prescricionais e Decadenciais
Authors: Dias Jonathas Alves 
Published: March 2020

A prescrição e a decadência são institutos intimamente relacionados ao tempo e fundados em interesses de ordem pública, capazes de extinguir a pretensão e o próprio direito, respectivamente. Neste contexto, torna-se relevante conhecer os critérios utilizados para identificar a partir de quando se inicia o decurso do prazo capaz de ocasionar consequências tão graves. Para este fim, foi realizada pesquisa bibliográfica de doutrina, legislação e jurisprudência. Demonstrou-se que para se identificar o dies a quo dos prazos prescricionais e decadenciais é necessário fazer uso de critérios distintos, com destaque para a faceta subjetiva da teoria da actio nata. Palavras-chave: Prescrição. Decadência. Actio nata. Dies a quo. AbstractPrescription and decadence are institutes closely related to time and founded on interests of public order, capable of extinguishing the pretension and the own right, respectively. In this context, it becomes relevant to know the criteria used to identify when the time period begins to cause such serious consequences. For this purpose, a bibliographical research was carried out on doctrine, legislation and jurisprudence. It was demonstrated that, in order to identify the dies a quo of the prescriptive and decadential deadlines, it is necessary to make use of different criteria, especially the subjective facet of the actio nata theory.Keywords: Prescription, decadence. Actio nata. Dies a quo.
Bajo peso al nacer: exploración de algunos factores de riesgo en el Hospital Universitario San José en Popayán (Colombia)
Authors: Daza Virginia , Jurado Wilson , Duarte Diana , Gich Ignasi , Sierra-Torres Carlos Hernán , Delgado-Noguera Mario 
Published: March 2020

Introducción: el bajo peso al nacer (BPN) es un importante problema de salud pública en los países en desarrollo y es un indicador de la salud materno-infantil. El peso al nacer por debajo de 2.500 g contribuye a problemas de salud materno-infantiles de corto y largo plazo.Objetivo: establecer los factores asociados con el bajo peso al nacer en el Hospital Universitario San José, Popayán (Colombia), en el período comprendido entre los años 2005 y 2006.Métodos y materiales: estudio de casos y controles. Los casos (n=344) fueron los recién nacidos con peso menor a 2.500 g que nacieron en este hospital. Los controles (n=483) fueron recién nacidos con peso mayor a 2.500 g que nacieron el mismo día. Se realizó una entrevista en mujeres después del parto para recoger información acerca de los factores de riesgo; y se estimó elOdds Ratio (OR, por sus siglas en inglés) y sus respectivos intervalos de confianza (IC95%) utilizando un modelo de regresión logística.Resultados: como factores de protección se consideraron: antecedentes de estrato socioeconómico medio/superior (OR=0,33; IC95% 0,12-0,91), sexo femenino del recién nacido (OR=0,73; IC95% 0,55-0,98), tener más de 5 controles prenatales (OR=0,54; IC 95% 0,39-0,75) y no tener antecedentes previos de BPN (OR=0,30; IC95% 0,15-0,58). Entre los factores de riesgo se encontraron: antecedentes de infecciones del tracto urinario (OR=1,78; IC95% 1,30-2,45) y cesárea anterior (OR=1,88; IC95% 1,13-3,16).Conclusión: el bajo peso al nacer está asociado con el estrato socioeconómico, por lo que intervenir en la falta de equidad social es un factor de importancia para la reducción del BPN en el área de influencia de este centro de atención terciario.
El control prenatal: una reflexión urgente
Authors: Cáceres-Manrique Flor de María 
Published: March 2020

Introducción y objetivo: este artículo tiene como objetivo reflexionar sobre la adherencia y las barreras de acceso al control prenatal (CPN). El CPN es la estrategia recomendada para detectar tempranamente riesgos del embarazo, instaurar el manejo adecuado, prevenir complicaciones y preparar a la gestante para el parto y la crianza. Sin embargo, no todas las embarazadas logran acceder al CPN por diferentes razones, la mayoría ajenas a su voluntad. Por tanto, es necesario reflexionar sobre las barreras de acceso y los motivos de las fallas en la adherencia al CPN para dirigir la investigación con el fin de hacer realidad el sueño de una maternidad saludable.
Resultados perinatales en gestaciones isoinmunizadas por el anticuerpo anti-rh(d), sometidas a transfusión fetal intrauterina en Rio de Janeiro, Brasil. Una serie de casos entre 1996 y 2006
Authors: Lobato Gustavo , Silveira Soncini Cristina 
Published: March 2020

Objetivo: evaluar los resultados perinatales de las pacientes isoinmunizadas sometidas a transfusión fetal intrauterina en el Instituto Fernandes Figueira (Río de Janeiro, Brasil).Materiales y métodos: estudio descriptivo retrospectivo, que incluyó a mujeres que requirieron transfusión fetal intrauterina entre 1996 y 2006. Se analizaron la historia perinatal, los datos de la asistencia prenatal durante la gestación actual y los resultados perinatales.Resultados: a un total de 85 madres isoinmunizadas, 90 gestaciones y 94 fetos (4 gestaciones gemelares) se les hicieron 316 transfusiones intrauterinas. Todas las 90 gestaciones exhibían anticuerpos anti-Rh(D). Doce fetos (12,8%) demostraban hidropesía en la primera transfusión y cinco (5,3%) tenían ascitis. Ocurrieron diez óbitos perinatales (4 óbitos fetales y 6 óbitos neonatales), totalizando una sobrevida de 89,4%. Fetos sin hidropesía tuvieron una sobrevida de 92,2% y fetos que presentaron hidropesía tuvieron un peor pronóstico, con sobrevida de 76,5%.Conclusiones: los resultados descritos confirman la eficacia y seguridad de la transfusión fetal intrauterina para el tratamiento de la anemia hemolítica inmune, realizada en centros de referencia para enfermedades perinatales.