bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing a system dynamics approach for CNG vehicles for low-carbon urban transport: a case study
Authors: Shamsapour Nima , Hajinezhad Ahmad , Noorollahi Younes 
Published: December 2020

Abstract
Today both the economic growth and expansion of urbanization have increased community access to private cars. Thus, the urban transportation has become a critical part of energy consumption and greenhouse gas emissions. The excessive dependence of urban transportation on high-emission fuels is the main obstacle to develop a low-carbon transport. Meanwhile, natural gas is a bridge fuel to develop a low-emission transport. To the best of our knowledge, there has been little attention towards the association between the development of natural gas-fueled vehicles and the CO2 emission. Therefore, the problem we studied is the role of compressed natural gas (CNG) vehicles in replacing high-emission fuels. In this study, we aimed to study this association by selecting the system dynamics approach due to the complexities of the social-economic system of transportation. In this modeling, different subsystems of the transport fleet were employed including CNG vehicles and urban transportation subsystems. Iran has used CNG as an alternative fuel in the transportation sector, making it one of the three leading countries in the use of natural gas in the urban transportation system. Our case study is focused on Tehran, which is the capital and the largest city of Iran.
In this paper, we considered several scenarios to replace the gasoline fuel in the private car sector and taxis and diesel fuel in the bus fleet with natural CNG fuel. The results show that the replacement of CNG fuel with high-emission fuels can have a significant effect on reducing CO2 emissions. In the synthetic scenario, CO2 emission will be decreased by 11.42% in 2030, as compared to the business as usual (BAU) scenario in this year. According to Iran’s commitment to the Paris Agreement, the emission of CO2 in Iran should normally be reduced by 4% in 2030, as compared to its amount in the BAU scenario. Therefore, Iran can easily fulfill its obligations in the urban transport sector only by replacing gasoline and diesel fuel with CNG.
Land and Transitional Justice in Brazil
Authors: Teló Fabricio , Gasparotto Alessandra , Medeiros Leonilde Servolo de , Saraiva Regina Coelly Fernandes 
Published: December 2020

Abstract
This article explores how Brazilian transitional justice has handled land dispossession suffered by peasants and Indigenous peoples during the dictatorship of 1964–1985. The article contextualizes the repression suffered by social movements fighting for land before and after the 1964 coup. Despite the fact that the National Truth Commission created a Working Group to investigate violence against peasants and Indigenous peoples, land dispossession was not considered a serious human rights violation. We also analyze the difficulties that peasants and Indigenous peoples have faced to access reparation programs implemented by the Brazilian state. Finally, we highlight the setbacks undertaken by the current and former federal governments (of Bolsonaro and Temer) in the field of transitional justice, which contribute to the continuation of violence and impunity in the present.
Developing a standardized protocol for computational sentiment analysis research using health-related social media data
Authors: He Lu , Yin Tingjue , Hu Zhaoxian , Chen Yunan , Hanauer David A , Zheng Kai 
Published: December 2020

Abstract

Objective
Sentiment analysis is a popular tool for analyzing health-related social media content. However, existing studies exhibit numerous methodological issues and inconsistencies with respect to research design and results reporting, which could lead to biased data, imprecise or incorrect conclusions, or incomparable results across studies. This article reports a systematic analysis of the literature with respect to such issues. The objective was to develop a standardized protocol for improving the research validity and comparability of results in future relevant studies.

Materials and Methods
We developed the Protocol of Analysis of senTiment in Health (PATH) based on a systematic review that analyzed common research design choices and how such choices were made, or reported, among eligible studies published 2010-2019.

Results
Of 409 articles screened, 89 met the inclusion criteria. A total of 16 distinctive research design choices were identified, 9 of which have significant methodological or reporting inconsistencies among the articles reviewed, ranging from how relevance of study data was determined to how the sentiment analysis tool selected was validated. Based on this result, we developed the PATH protocol that encompasses all these distinctive design choices and highlights the ones for which careful consideration and detailed reporting are particularly warranted.

Conclusions
A substantial degree of methodological and reporting inconsistencies exist in the extant literature that applied sentiment analysis to analyzing health-related social media data. The PATH protocol developed through this research may contribute to mitigating such issues in future relevant studies.
Strong Sexual Selection Does Not Induce Population Differentiation in a Fish Species with High Dispersal Potential: The Curious Case of the Worm PipefishNerophis lumbriciformis(Teleostei: Syngnathidae)
Authors: Mendes Tito , Gomes Cidália , Monteiro Nuno , Antunes Agostinho 
Published: December 2020

AbstractHigh levels of population differentiation are a common demographic pattern in syngnathids, even at small geographical scales. This is probably the end result of the common life history traits observed within the family, involving limited dispersal capabilities and strong habitat dependency. The worm pipefish, Nerophis lumbriciformis, which displays all these characteristics, also presents an additional variable potentially able to promote population differentiation: high sexual selection intensity, especially at the extremes of its distribution. Nevertheless, an early life pelagic stage, which presumably allows for admixture, could prevent population structuring. Here, we assessed the phylogeography of N. lumbriciformis through the amplification of the cytochrome b, 12S, and 16S rDNA mitochondrial markers as well as the rhodopsin nuclear marker, performed upon 119 individuals. We observed a genetically homogeneous population with indications of extensive gene flow. We tentatively attribute this finding to the dispersal potential of the species’ pelagic larvae, supported by marine currents acting as major dispersal vectors. We also detected a signal of expansion towards the poles, consistent with the current climate change scenario. Despite the marked latitudinal differences in the phenotype of reproducing worm pipefish, the absence of clear population structuring suggests that phenotypic plasticity can have a significant role in the expression of sexual selection-related traits.
Adjuvant and neoadjuvant chemotherapy for soft tissue sarcomas: JCOG Bone and Soft Tissue Tumor Study Group
Authors: Tanaka Kazuhiro , Ozaki Toshifumi 
Published: December 2020

Abstract
The standard therapy for all localized soft tissue sarcomas is surgical resection of the tumor. For patients with soft tissue sarcomas who are at high risk for recurrence and/or metastasis, perioperative chemotherapy is a potential treatment option. Adriamycin plus ifosfamide is currently the most promising chemotherapy regimen for localized soft tissue sarcomas. Randomized controlled trials and meta-analyses of adjuvant postoperative chemotherapy for soft tissue sarcomas have suggested that adjuvant chemotherapy may provide an advantage, however small, compared with surgery alone. On the other hand, recent randomized trials have demonstrated the efficacy of neoadjuvant preoperative chemotherapy using full-dose anthracycline plus ifosfamide for high-risk soft tissue sarcomas and showed survival benefits in patients with large, deep-seated and high-grade soft tissue sarcomas of the trunk and extremities. In this review, adjuvant and neoadjuvant chemotherapies for soft tissue sarcomas and future perspectives are discussed.
Diversity of plant heat shock factors: regulation, interactions, and functions
Authors: Andrási Norbert , Pettkó-Szandtner Aladár , Szabados László 
Published: December 2020

AbstractPlants heat shock factors (HSFs) are encoded by large gene families with variable structure, expression, and function. HSFs are components of complex signaling systems that control responses not only to high temperatures but also to a number of abiotic stresses such as cold, drought, hypoxic conditions, soil salinity, toxic minerals, strong irradiation, and to pathogen threats. Here we provide an overview of the diverse world of plant HSFs through compilation and analysis of their functional versatility, diverse regulation, and interactions. Bioinformatic data on gene expression profiles of Arabidopsis HSF genes were re-analyzed to reveal their characteristic transcript patterns. While HSFs are regulated primarily at the transcript level, alternative splicing and post-translational modifications such as phosphorylation and sumoylation provides further variability. Plant HSFs are involved in an intricate web of protein–protein interactions which adds considerable complexity to their biological function. A list of such interactions was compiled from public databases and published data, and discussed to pinpoint their relevance in transcription control. Although most fundamental studies of plant HSFs have been conducted in the model plant, Arabidopsis, information on HSFs is accumulating in other plants such as tomato, rice, wheat, and sunflower. Understanding the function, interactions, and regulation of HSFs will facilitate the design of novel strategies to use engineered proteins to improve tolerance and adaptation of crops to adverse environmental conditions.
Higher order initial conditions for mixed baryon–CDM simulations
Authors: Hahn Oliver , Rampf Cornelius , Uhlemann Cora 
Published: December 2020

ABSTRACT
We present a novel approach to generate higher order initial conditions (ICs) for cosmological simulations that take into account the distinct evolution of baryons and dark matter. We focus on the numerical implementation and the validation of its performance, based on both collisionless N-body simulations and full hydrodynamic Eulerian and Lagrangian simulations. We improve in various ways over previous approaches that were limited to first-order Lagrangian perturbation theory (LPT). Specifically, we (1) generalize nth-order LPT to multifluid systems, allowing 2LPT or 3LPT ICs for two-fluid simulations, (2) employ a novel propagator perturbation theory to set up ICs for Eulerian codes that are fully consistent with 1LPT or 2LPT, (3) demonstrate that our ICs resolve previous problems of two-fluid simulations by using variations in particle masses that eliminate spurious deviations from expected perturbative results, (4) show that the improvements achieved by going to higher order PT are comparable to those seen for single-fluid ICs, and (5) demonstrate the excellent (i.e. few per cent level) agreement between Eulerian and Lagrangian simulations, once high-quality initial conditions are used. The rigorous development of the underlying perturbation theory is presented in a companion paper. All presented algorithms are implemented in the monofonic music-2 package that we make publicly available.
The PAU survey: Ly α intensity mapping forecast
Authors: Renard Pablo , Gaztanaga Enrique , Croft Rupert , Cabayol Laura , Carretero Jorge , Eriksen Martin , Fernandez Enrique , García-Bellido Juan , Miquel Ramon , Padilla Cristobal , Sanchez Eusebio , Tallada-Crespí Pau 
Published: December 2020

ABSTRACT
In this work, we explore the application of intensity mapping to detect extended Ly α emission from the IGM via cross-correlation of PAUS images with Ly α forest data from eBOSS and DESI. Seven narrow-band (FWHM = 13 nm) PAUS filters have been considered, ranging from 455 to 515 nm in steps of 10 nm, which allows the observation of Ly α emission in a range 2.7 &lt; z &lt; 3.3. The cross-correlation is simulated first in an area of 100 deg2 (PAUS projected coverage), and second in two hypothetical scenarios: a deeper PAUS (complete up to iAB &lt; 24 instead of iAB &lt; 23, observation time ×6), and an extended PAUS coverage of 225 deg2 (observation time ×2.25). A hydrodynamic simulation of size 400 Mpc h−1 is used to simulate both extended Ly α emission and absorption, while the foregrounds in PAUS images have been simulated using a lightcone mock catalogue. Using an optimistic estimation of uncorrelated PAUS noise, the total probability of a non-spurious detection is estimated to be 1.8 per cent and 4.5 per cent for PAUS-eBOSS and PAUS-DESI, from a run of 1000 simulated cross-correlations with different realisations of instrumental noise and quasar positions. The hypothetical PAUS scenarios increase this probability to 15.3 per cent (deeper PAUS) and 9.0 per cent (extended PAUS). With realistic correlated noise directly measured from PAUS images, these probabilities become negligible. Despite these negative results, some evidences suggest that this methodology may be more suitable to broad-band surveys.
The fragility of a structurally diverse duplication block triggers recurrent genomic amplification
Authors: Suzuki Ryusuke , Murata Michael M , Manguso Nicholas , Watanabe Takaaki , Mouakkad-Montoya Lila , Igari Fumie , Rahman Md Maminur , Qu Ying , Cui Xiaojiang , Giuliano Armando E , Takeda Shunichi , Tanaka Hisashi 
Published: December 2020

AbstractThe human genome contains hundreds of large, structurally diverse blocks that are insufficiently represented in the reference genome and are thus not amenable to genomic analyses. Structural diversity in the human population suggests that these blocks are unstable in the germline; however, whether or not these blocks are also unstable in the cancer genome remains elusive. Here we report that the 500 kb block called KRTAP_region_1 (KRTAP-1) on 17q12–21 recurrently demarcates the amplicon of the ERBB2 (HER2) oncogene in breast tumors. KRTAP-1 carries numerous tandemly-duplicated segments that exhibit diversity within the human population. We evaluated the fragility of the block by cytogenetically measuring the distances between the flanking regions and found that spontaneous distance outliers (i.e DNA breaks) appear more frequently at KRTAP-1 than at the representative common fragile site (CFS) FRA16D. Unlike CFSs, KRTAP-1 is not sensitive to aphidicolin. The exonuclease activity of DNA repair protein Mre11 protects KRTAP-1 from breaks, whereas CtIP does not. Breaks at KRTAP-1 lead to the palindromic duplication of the ERBB2 locus and trigger Breakage-Fusion-Bridge cycles. Our results indicate that an insufficiently investigated area of the human genome is fragile and could play a crucial role in cancer genome evolution.
Stop! Graphic Health Warnings Enhance Inhibitory Control in Adolescents: An Event-Related Potential Study
Authors: Gantiva Carlos , Sotaquirá Miguel , Hernández-Mateus Vanessa , Restrepo-García Alejandro , Camacho Katherine 
Published: December 2020

AbstractIntroductionThe majority of smokers begin consumption in adolescence and the earlier initiation of cigarette smoking is associated with a greater likelihood of cigarette dependence. Graphic health warnings (GHW) are one of the most used strategies to communicate the consequences of cigarette smoking, but little is known about their ability to increase inhibitory control and thus prevent consumption. The objective of the present study was to evaluate the effects of different sizes of GHWs on inhibitory control in adolescents. We hypothesized that GHWs promote inhibitory control, and increasing GHW size, enhance inhibitory control.MethodsFifty-nine participants completed a Go/No-Go task during electroencephalographic recording. The No-Go stimuli were pictures of cigarette packs without GHWs, and cigarette packs with GHWs that covered 30% or 60% of the front (main side) of the pack. The event-related potential N200 component and behavioral measures in the Go/No-Go task were analyzed.ResultsSeparate mixed-model analysis of variance (ANOVAs) were used for N200 component (amplitude and latency) and behavioral data. The GHWs increased the amplitude of the N200 potential, especially GHWs that covered 60% of the front of the pack. The behavioral data showed that GHWs that covered 60% of the front of the pack generated higher a percentage of accuracy in No-Go trials (ie, fewer commission errors).ConclusionsThese results suggest that GHWs increase inhibitory control in adolescents, especially when the GHWs cover 60% of the front of the cigarette pack.ImplicationsGHWs with an increased size (60% of the front of the cigarette pack vs. 30%, the minimum size, proposed by the World Health Organization) recruit additional cognitive resources and thus can effectively increase inhibitory control both in adolescent smokers and nonsmokers. Accordingly, the use of larger GHW has the potential of becoming an effective public policy strategy to inhibit smoking in adolescents.
The management of Sjögren’s syndrome: British Society for Rheumatology guideline scope
Authors: Price Elizabeth , Allen Alexander , Rauz Saaeha , Tappuni Anwar , Sutcliffe Nurhan , Bombardieri Michele , Carty Sara , Ciurtin Coziana , Crampton Bridget , Duncalfe Lisa , Fisher Benjamin , Glennon Peter , Hackett Katie L , Larkin Genevieve , Ng Wan-Fai , Ramanan Athimalaipet V , Rassam Saad , Walsh Stephen B , Bowman Simon 
Published: December 2020

Abstract
The guideline will be developed using the methods and processes outlined in Creating Clinical Guidelines: Our Protocol [1]. This development process to produce guidance, advice and recommendations for practice has National Institute for Health and Care Excellence (NICE) accreditation.
Paraquat Inhalation, a Translationally Relevant Route of Exposure: Disposition to the Brain and Male-Specific Olfactory Impairment in Mice
Authors: Anderson Timothy , Merrill Alyssa K , Eckard Matthew L , Marvin Elena , Conrad Katherine , Welle Kevin , Oberdörster Günter , Sobolewski Marissa , Cory-Slechta Deborah A 
Published: December 2020

Abstract
Epidemiological and experimental studies have associated oral and systemic exposures to the herbicide paraquat (PQ) with Parkinson’s disease. Despite recognition that airborne particles and solutes can be directly translocated to the brain via olfactory neurons, the potential for inhaled PQ to cause olfactory impairment has not been investigated. This study sought to determine if prolonged low-dose inhalation exposure to PQ would lead to disposition to the brain and olfactory impairment, a prodromal feature of Parkinson’s disease. Adult male and female C57BL/6J mice were exposed to PQ aerosols in a whole-body inhalation chamber for 4 h/day, 5 days/week for 4 weeks. Subsets of mice were sacrificed during and after exposure and PQ concentrations in various brain regions (olfactory bulb, striatum, midbrain, and cerebellum) lung, and kidney were quantified via mass spectrometry. Alterations in olfaction were examined using an olfactory discrimination paradigm. PQ inhalation resulted in an appreciable burden in all examined brain regions, with the highest burden observed in the olfactory bulb, consistent with nasal olfactory uptake. PQ was also detected in the lung and kidney, yet PQ levels in all tissues returned to control values within 4 weeks post exposure. PQ inhalation caused persistent male-specific deficits in olfactory discrimination. No effects were observed in females. These data support the importance of route of exposure in determination of safety estimates for neurotoxic pesticides, such as PQ. Accurate estimation of the relationship between exposure and internal dose is critical for risk assessment and public health protection.
Extractive concentrations and cellular-level distributions change radially from outer to inner heartwood in Scots pine
Authors: Belt Tiina , Venäläinen Martti , Altgen Michael , Harju Anni , Rautkari Lauri 
Published: December 2020

Abstract
The heartwood of many wood species is rich in extractives, which improve the wood material’s resistance to biological attack. Their concentration is generally higher in outer than inner heartwood, but the exact radial changes in aging heartwood remain poorly characterized. This investigation studied these radial changes in detail in Scots pine (Pinus sylvestris L.), using radial sample sequences prepared from three different trees. Stilbene and resin acid contents were first measured from bulk samples, after which the extractive contents of individual heartwood annual rings were investigated using Raman spectroscopy and fluorescence microscopy. Raman imaging and fluorescence microscopy were also used to study the cellular-level distributions of extractives in different annual rings. Although there were substantial differences between the trees, the content and distribution of stilbenes seemed to follow a general radial trend. The results suggest that stilbenes are absorbed into heartwood tracheid cell walls from small stilbene-rich extractive deposits over several years and then eventually transform into non-extractable compounds in aging heartwood. Resin acids followed no consistent radial trends, but their content was strongly connected to the frequency of large extractive deposits in latewood tracheid lumens. The results highlight the variability of heartwood extractives: their content and distribution vary not only between trees but also between and even within the annual rings of a single tree. This high variability is likely to have important effects on the properties of heartwood and the utilization of heartwood timber.
Altered Permeability Of The Blood‐CSF Barrier In Chronic Migraine
Authors: Gross Noah B. , Sweeney Melanie , Sagare Abhay , Zlokovic Berislav , Castor Katherine , Fonteh Alfred N. , Arakaki Xianghong , Woldeamanuel Yohannes W. , Cowan Robert P. , Harrington Michael G. 
Published: December 2020

BackgroundMolecular communication from blood circulation to brain is tightly regulated at multiple biological barriers, but is disrupted in a variety of diseases, disorders, and infections. Recent human and animal data in migraine research has shown conflicting results regarding barrier disruption. These contradictions require resolution because a leaky barrier will expose the brain to potentially harmful components with diverse deleterious effects on brain function.MethodsSince blood‐to‐CSF transfer studies have not yet been performed in migraineurs, we studied surrogate biomarkers of barrier disruption in blood and CSF from non‐headache suffering controls and chronic migraine sufferers.ResultsWhen compared to controls, study participants with chronic migraine had clear evidence of barrier leak based on their higher CSF—blood albumin ratio, CSF fibrinogen levels, and CSF levels of the pericyte biomarker, soluble platelet‐derived growth factor receptor β. To test if other blood components were leaking through this barrier, we examined how CSF and blood lipids relate to the CSF—blood albumin ratio. The CSF—blood ratios of trans palmitoleic acid, linoleic acid, and ceramide were higher in chronic migraine and these lipid ratios correlated significantly with the CSF—blood albumin index, consistent with their derivation, at least partly, from a leaking barrier.ConclusionWe conclude that individuals with chronic migraine have distinct disruption of central nervous system (CNS) barriers that allows leakage into the CNS of multiple blood components, including proteins and lipids, and which likely results from, and contributes to the pathophysiology of migraine. The blood‐brain barrier and molecules that leak into the CNS are potential treatment targets.Support or Funding InformationThe National Institutes of Health, R01 NS043295, Higgins Family TrustsThis abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.