bluuebunny/crossref_metadata_2025_split huggingface dataset:
Loss characteristics of superconducting pancake, solenoid and spiral coils for wireless power transfer
Authors: Machura Philip , Zhang Hongye , Kails Kevin , Li Quan 
Published: May 2020

Abstract
Wireless power transfer (WPT) is an emerging technology with widespread applications, such as wireless charging for electric vehicles (EVs), which has become a major point of interest. Conventionally, it is used for stationary charging, but also dynamic systems emerge. Key drawbacks of standard WPT systems are the limited transfer distance between the copper coils and the transfer efficiency. By employing high-temperature superconductors (HTS) as coil material these limitations can be alleviated. However, HTS coils have highly nonlinear ac loss characteristics, which will be studied. This paper investigates the transport current loss and the magnetisation loss of HTS coils individually and when combined in the high frequency range relevant to WPT for EVs. A multilayer 2D axisymmetric coil model based on
H
-formulation is proposed and validated by experimental results as the HTS film layer is inapplicable at such frequencies. Three of the most commonly employed coil configurations, namely: double pancake, solenoid and circular spiral are examined. While spiral coils experience the highest transport current loss, solenoid coils are subject to the highest magnetisation loss due to the overall distribution of the turns. Furthermore, a transition frequency is defined for each coil when losses in the copper layer exceed the HTS losses. It is much lower for coils due to the interactions between the different turns compared to single HTS tapes. At higher frequencies, the range of magnetic field densities, causing a shift where the highest losses occur, decreases until losses in the copper stabilisers always dominate. In addition, case studies investigating the suitability of HTS-WPT are proposed.
Toward heterogeneous information fusion: bipartite graph convolutional networks for in silico drug repurposing
Authors: Wang Zichen , Zhou Mu , Arnold Corey 
Published: May 2020

Abstract

Motivation
Mining drug–disease association and related interactions are essential for developing in silico drug repurposing (DR) methods and understanding underlying biological mechanisms. Recently, large-scale biological databases are increasingly available for pharmaceutical research, allowing for deep characterization for molecular informatics and drug discovery. However, DR is challenging due to the molecular heterogeneity of disease and diverse drug–disease associations. Importantly, the complexity of molecular target interactions, such as protein–protein interaction (PPI), remains to be elucidated. DR thus requires deep exploration of a multimodal biological network in an integrative context.

Results
In this study, we propose BiFusion, a bipartite graph convolution network model for DR through heterogeneous information fusion. Our approach combines insights of multiscale pharmaceutical information by constructing a multirelational graph of drug–protein, disease–protein and PPIs. Especially, our model introduces protein nodes as a bridge for message passing among diverse biological domains, which provides insights into utilizing PPI for improved DR assessment. Unlike conventional graph convolution networks always assuming the same node attributes in a global graph, our approach models interdomain information fusion with bipartite graph convolution operation. We offered an exploratory analysis for finding novel drug–disease associations. Extensive experiments showed that our approach achieved improved performance than multiple baselines for DR analysis.

Availability and implementation
Source code and preprocessed datasets are at: https://github.com/zcwang0702/BiFusion.
MetaSanity: an integrated microbial genome evaluation and annotation pipeline
Authors: Neely Christopher J , Graham Elaina D , Tully Benjamin J 
Published: May 2020

Abstract

Summary
As the importance of microbiome research continues to become more prevalent and essential to understanding a wide variety of ecosystems (e.g. marine, built, host associated, etc.), there is a need for researchers to be able to perform highly reproducible and quality analysis of microbial genomes. MetaSanity incorporates analyses from 11 existing and widely used genome evaluation and annotation suites into a single, distributable workflow, thereby decreasing the workload of microbiologists by allowing for a flexible, expansive data analysis pipeline. MetaSanity has been designed to provide separate, reproducible workflows that (i) can determine the overall quality of a microbial genome, while providing a putative phylogenetic assignment, and (ii) can assign structural and functional gene annotations with varying degrees of specificity to suit the needs of the researcher. The software suite combines the results from several tools to provide broad insights into overall metabolic function. Importantly, this software provides built-in optimization for ‘big data’ analysis by storing all relevant outputs in an SQL database, allowing users to query all the results for the elements that will most impact their research.

Availability and implementation
MetaSanity is provided under the GNU General Public License v.3.0 and is available for download at https://github.com/cjneely10/MetaSanity. This application is distributed as a Docker image. MetaSanity is implemented in Python3/Cython and C++. Instructions for its installation and use are available within the GitHub wiki page at https://github.com/cjneely10/MetaSanity/wiki, and additional instructions are available at https://cjneely10.github.io/year-archive/. MetaSanity is optimized for users with limited programing experience.

Supplementary information
Supplementary data are available at Bioinformatics online.
Mixture and Concentration Effects on Odorant Receptor Response Patterns In Vivo
Authors: McClintock Timothy S , Wang Qiang , Sengoku Tomoko , Titlow William B , Breheny Patrick 
Published: May 2020

Abstract
Natural odors are mixtures of volatile chemicals (odorants). Odors are encoded as responses of distinct subsets of the hundreds of odorant receptors and trace amine-associated receptors expressed monogenically by olfactory sensory neurons. This is an elegantly simple mechanism for differentially encoding odors but it is susceptible to complex dose–response relationships and interactions between odorants at receptors, which may help explain olfactory phenomena, such as mixture suppression, synthetic versus elemental odor processing, and poorly predictable perceptual outcomes of new odor mixtures. In this study, in vivo tests in freely behaving mice confirm evidence of a characteristic receptor response pattern consisting of a few receptors with strong responses and a greater number of weakly responding receptors. Odorant receptors responsive to an odor are often unrelated and widely divergent in sequence, even when the odor consists of a single species of odorant. Odorant receptor response patterns to a citrus odor broaden with concentration. Some highly sensitive receptors respond only to a low concentration but others respond in proportion to concentration, a feature that may be critical for concentration-invariant perception. Other tests find evidence of interactions between odorants in vivo. All of the odorant receptor responses to a moderate concentration of the fecal malodor indole are suppressed by a high concentration of the floral odorant, α-ionone. Such suppressive effects are consistent with prior evidence that odorant interactions at individual odorant receptors are common.
Placental lncRNA expression associated with placental cadmium concentrations and birth weight
Authors: Hussey Michael R , Burt Amber , Deyssenroth Maya A , Jackson Brian P , Hao Ke , Peng Shouneng , Chen Jia , Marsit Carmen J , Everson Todd M 
Published: May 2020

AbstractHeavy metal exposures, such as cadmium, can have negative effects on infant birth weight (BW)—among other developmental outcomes—with placental dysfunction potentially playing a role in these effects. In this study, we examined how differential placental expression of long non-coding RNAs (lncRNAs) may be associated with cadmium levels in placenta and whether differences in the expression of those lncRNAs were associated with fetal growth. In the Rhode Island Child Health Study, we used data from Illumina HiSeq whole transcriptome RNA sequencing (n = 199) to examine association between lncRNA expression and measures of infant BW as well as placental cadmium concentrations controlled for appropriate covariates. Of the 1191 lncRNAs sequenced, 46 demonstrated associations (q &lt; 0.05) with BW in models controlling for infant sex, maternal age, BMI, maternal education, and smoking during pregnancy. Furthermore, four of these transcripts were associated with placental cadmium concentrations, with MIR22HG and ERVH48-1 demonstrating increases in expression associated with increasing cadmium exposure and elevated odds of small for gestational age birth, while AC114763.2 and LINC02595 demonstrated reduced expression associated with cadmium, but elevated odds of large for gestational age birth with increasing expression. We identified relationships between lncRNA expression with both placental cadmium concentrations and BW. This study provides evidence that disrupted placental expression of lncRNAs may be a part of cadmium’s mechanisms of reproductive toxicity.
Pre-procedural planning of transcatheter mitral valve replacement in mitral stenosis with multi-detector tomography-derived 3D modeling and printing: a case report
Authors: Ooms Joris , Minet Magali , Daemen Joost , Van Mieghem Nicolas 
Published: May 2020

Abstract

Background
Transcatheter mitral valve replacement (TMVR) may be a valuable treatment option for mitral annular calcification and severe mitral stenosis (MS) in patients at high operative risk. Pre-procedural virtual and printed simulations may aid in procedure planning, device sizing, and mitigate complications such as valve embolization or left ventricular outflow tract (LVOT) obstruction.

Case summary
We describe a case of TMVR in which multi-detector computed tomography (MDCT) derived, three-dimensional virtual planning and a 3D-printed model of the patients’ left heart provided enhanced understanding of an individual patient’s unique anatomy to determine feasibility, device sizing, and risk stratification. This resulted in deployment of an adequately sized valve. Post-TMVR LVOT obstruction was treated with LVOT balloon dilatation and percutaneous transluminal septal myocardial ablation.

Discussion
Advanced MDCT-derived planning techniques introduce consistent 3D modeling and printing to enhance understanding of intracardiac anatomical relationships and test device implantation. Still, static measurements do not feature haemodynamic factors, tissue, or device characteristics and do not predict device host interaction. Transcatheter mitral valve replacement is feasible in MS when adequately pre-procedurally planned. Multi-detector computed tomography-derived, 3D, virtual and printed models contribute to adequate planning in terms of determining patient eligibility, procedure feasibility, and device sizing. However, static 3D modeling cannot completely eliminate the risk of peri-procedural complications.
The Politics of Apology and the Prospects for ‘Post-conflict’ Reconciliation: The Case of the Provisional Irish Republican Movement
Authors: Hopkins Stephen 
Published: May 2020

Abstract
This article analyses the Irish Provisional Republican movement and the evolution of its approach to the politics of apology. The first section analyses recent scholarship regarding ‘political apologies’, and provides a challenge to the existing literature, which concentrates upon ‘official’ or state apologies, rather than examples involving non-state armed groups (paramilitary or ‘terrorist’ organisations). This section argues that it remains difficult to discern an adequate general model for establishing criteria for a ‘successful’ or ‘sincere’ political apology involving such groups. The second section considers a number of case studies, including the statements of the IRA in 2002, and after the Enniskillen bombing in 1987. It is argued that the Provisional movement’s apologies have not generally proven helpful to its declared aim of post-conflict reconciliation. This article argues that attempted apologies or quasi-apologies by non-state groups may not ameliorate the sense of grievance experienced by victims/survivors, and may also serve to revivify social and political ‘framing battles’ over the past.
A Generalized Framework for Moral Dilemmas Involving Autonomous Vehicles: A Commentary on Gill
Authors: Novak Thomas P 
Published: May 2020

AbstractBy using scenarios based on moral dilemmas, Gill (2020) found that when consumers are riding in an autonomous vehicle (AV), they are more willing to harm a pedestrian than when they, themselves, are driving a regular car. By taking a first-person perspective, in contrast to most prior research that has taken a third-person perspective, the problem is framed in a personal way that allows identification of a mechanism of responsibility attribution. In this commentary, a generalized framework is developed in which we can locate the work of Gill (2020), as well as prior research that uses moral dilemmas, to understand how consumers believe that AVs should respond when faced with competing life-and-death alternatives. The framework shows the distinct positions that research to date has adopted, points out gaps in research, and suggests a family of four research agendas that can be pursued going forward, driven in large part by the perspective taken to the moral dilemma. Research employing these different perspectives, including the unresearched problem of taking the perspective of the object, holds promise for using moral dilemmas for enabling our understanding of consumer experience and consumer–object relationships with AVs.
Electropenetrographic Comparison of Feeding Behavior of Dichelops furcatus (Hemiptera: Heteroptera: Pentatomidae) on Soybean and Spring Cereals
Authors: Lucini Tiago , Panizzi Antônio R 
Published: May 2020

AbstractWe used electropenetrography to quantify and compare counts and durations of selected waveforms, produced by adult females of the stink bug Dichelops furcatus (F.). Insects fed on immature soybean pods and immature seed heads of four spring cereals: wheat, black oat, barley, and rye. On all foods, bugs spent over 60% of their plant access time in non-probing activities. This total waveform duration was significantly longer on barley and rye compared to those on soybean and oat; wheat was intermediate. Considering only probing activities, bugs spent longer durations (ca. 2×), on soybean and oat compared to barley, rye, and wheat plants. Bugs produced significantly more pathway events on soybean and rye than on wheat and barley; with a significantly shorter duration per event on rye. The counts and durations of xylem ingestion did not differ among foods. Cell rupturing activities on seeds were longer on soybean (ca. 23%) and oat (ca. 21%), than on barley and rye (ca. 6%). The durations of ingestion events on seeds were significantly shorter on soybean (over 3×) compared to those on barley and wheat; oat and rye were intermediate. However, the ingestion duration per insect did not show significant difference among foods. Results demonstrated that D. furcatus spent more time overall in probing activities on soybean and oat; whereas, rye and barley presented the worst feeding behavior. This study provides important background information for further quantitative studies of stink bugs on different plants, such as development of resistant host plants.
The Effects of Temperature and Humidity on a Field Population of Bradysia odoriphaga (Diptera: Sciaridae)
Authors: Shi Cai-hua , Hu Jing-rong , Zhang You-jun 
Published: May 2020

Abstract
The production of Chinese chives is reduced throughout China due to a root-feeding dipteran pest Bradysia odoriphaga Yang et Zhang (Diptera: Sciaridae), therefore deciphering the conditions influencing its growth and development are important in developing ecological control strategies. A study was conducted from 2014 to 2017 to determine the relationship between the abundance of B. odoriphaga and temperature (atmospheric and soil), soil water content, and atmospheric humidity in a Chinese chive field in Beijing City, China. Numbers of adults peaked in March and October to November and were lowest in July to August and December to next February; numbers of larvae were highest in December to next February and lowest in July to August. From 2014 to 2017, the numbers of adults and larvae were significantly correlated with monthly mean atmospheric temperatures and soil temperatures, but were not significantly correlated with monthly mean atmospheric relative humidity and soil water content. However, for both adults and larvae, numbers were significantly greater with high soil water contents compared with drought treatment. The results of this study suggest that the very low soil water contents, high atmospheric temperatures, and high soil temperatures were critical for regulating field populations of B. odoriphaga.
Tomato Yellow Leaf Curl Virus Infection Alters Bemisia tabaci MED (Hemiptera: Aleyrodidae) Vulnerability to Flupyradifurone
Authors: Liu Baiming , Preisser Evan L , Jiao Xiaoguo , Zhang Youjun 
Published: May 2020

Abstract
The whitefly, Bemisia tabaci Gennadius, is a major phloem-feeding pest of agricultural crops that is also an important vector of many plant diseases. The B. tabaci Mediterranean (‘MED’) biotype is a particularly effective vector of Tomato yellow leaf curl virus (TYLCV), a devastating plant pathogen. Although insecticides play an important role in the control of MED and TYLCV, little is known about how TYLCV infection affects MED susceptibility to insecticides. We conducted research addressing how MED susceptibility to flupyradifurone, the first commercially available systemic control agent derived from the butenolide class of insecticides, was affected by TYLCV infection. We first conducted bioassays determining the LC15 and LC50 for control and viruliferous MED feeding on either water- or insecticide-treated plants. We next measured several demographic parameters of control and viruliferous MED exposed to either insecticide- or water-treated plants. TYLCV infection increased MED tolerance of flupyradifurone: the LC15 and LC50 of viruliferous MED were double that of uninfected MED. Viral infection also altered MED demographic responses to flupyradifurone, but in an inconsistent manner. Although the ability of TYLCV and other persistently transmitted viruses to benefit Bemisia via manipulation of host plant defense is well known, this appears to be the first example of virally mediated changes in vector susceptibility to an insecticide.
The Alzheimer Disease-Causing Presenilin-1 L435F Mutation Causes Increased Production of Soluble Aβ43 Species in Patient-Derived iPSC-Neurons, Closely Mimicking Matched Patient Brain Tissue
Authors: Oakley Derek H , Chung Mirra , Klickstein Naomi , Commins Caitlin , Hyman Bradley T , Frosch Matthew P 
Published: May 2020

Abstract
Familial Alzheimer disease-causing mutations in Presenilin 1 (PSEN1) are generally thought to shift the processing of APP toward longer, more amyloidogenic Aβ fragments. However, certain PSEN1 mutations cause severe reduction in gamma secretase function when expressed in the homozygous state, thus challenging the amyloid hypothesis. We sought to evaluate the effects of one such mutation, PSEN1 L435F, in more physiologic conditions and genetic contexts by using human induced pluripotent stem cell (iPSC)-derived neurons from an individual with familial AD (fAD) linked to the PSEN1 L435F mutation, and compared the biochemical phenotype of the iPS-derived neurons with brain tissue obtained at autopsy from the same patient. Our results demonstrate that in the endogenous heterozygous state, the PSEN1 L435F mutation causes a large increase in soluble Aβ43 but does not change the overall levels of soluble Aβ40 or Aβ42 when compared with control iPSC-neurons. Increased pathologically phosphorylated tau species were also observed in PSEN1-mutant iPSC-neurons. Concordant changes in Aβ species were present in autopsy brain tissue from the same patient. Finally, the feasibility of using Aβ43 immunohistochemistry of brain tissue to identify fAD cases was evaluated in a limited autopsy case series with the finding that strong Aβ43 staining occurred only in fAD cases.
Distribution of TDP-43 Pathology in Hippocampal Synaptic Relays Suggests Transsynaptic Propagation in Frontotemporal Lobar Degeneration
Authors: Jamshidi Pouya , Kim Garam , Shahidehpour Ryan K , Bolbolan Kabriya , Gefen Tamar , Bigio Eileen H , Mesulam Marek-Marsel , Geula Changiz 
Published: May 2020

Abstract
Hyperphosphorylation, nuclear depletion, and aggregation of TDP-43 in ubiquitinated inclusions is a hallmark of frontotemporal lobar degeneration (FTLD-TDP). Evidence of potential spread of TDP-43 along synaptic connections in the human is largely limited to qualitative and semiquantitative observations. We quantitatively investigated potential transsynaptic propagation of TDP-43 across the well-established chain of single synaptic connections of the hippocampus. Hippocampi from 5 participants with clinical diagnoses of primary progressive aphasia and 2 participants with behavioral variant frontotemporal dementia, all with postmortem diagnoses of FTLD-TDP, were examined. TDP-43-positive mature (darkly stained) and pre-inclusions (diffuse puncta or fibrillar staining) in the granule cell layer of dentate gyrus (DG) and pyramidal cell layers of Cornu Ammonis (CA)3, CA2, and CA1 were quantified using unbiased stereology. The density of mature TDP-43 inclusions was higher in the DG than in the CA fields (p &lt; 0.05). There were no differences in inclusion densities across the CA fields. TDP-43 pre-inclusions densities were not different across the 4 subregions. There was significantly higher preinclusion density than mature inclusions in CA3, but not in other subregions. Analysis of normalized total counts in place of densities revealed virtually identical results. Our finding of greatest mature inclusion deposition in the DG, coupled with more preinclusions than mature inclusions at the next relay station (CA3), and reduced densities of both in CA2-CA1, provide evidence in support of a sequential transsynaptic propagation mechanism of TDP-43 aggregates.
Localized Hypertrophic Neuropathy as a Neoplastic Manifestation of KRAS-Mediated RASopathy
Authors: Vizcaino M Adelita , Belzberg Allan , Ahlawat Shivani , Belakhoua Sarra , Chen Liam , Staedtke Verena , Rodriguez Fausto J 
Published: May 2020

Abstract
Localized hypertrophic neuropathy is a rare Schwann cell proliferation that usually affects single nerves from the extremities, and it is of unclear etiology in its pure form. RASopathies are a defined group of genetic diseases with overlapping clinical features, usually secondary to germline mutations in genes encoding either components or regulators of the RAS/MAPK pathway. Herein, we report an 11-year-old boy presenting with café au lait spots and right leg length discrepancy. A fascicular nerve biopsy of the tibial nerve demonstrated a Schwann cell proliferation with prominent onion-bulb formation, satisfying criteria for localized hypertrophic neuropathy. Molecular genetic analysis demonstrated identical KRAS mutations (c38_40dupGCG) in the peripheral nerve lesion and melanocytes from café au lait spots, but not in blood, supporting a diagnosis of a KRAS-mediated rasopathy with mosaicism. Immunohistochemical staining in the peripheral nerve lesion demonstrated strong pERK staining consistent with downstream MAPK pathway activation. This report suggests that at least a subset of localized hypertrophic neuropathies are bonafide, well-differentiated Schwann cell neoplasms developing through oncogenic RAS signaling, which provides new insights into the controversial entity historically known as localized hypertrophic neuropathy.