bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of step-count monitoring interventions on physical activity: systematic review and meta-analysis of community-based randomised controlled trials in adults
Authors: Chaudhry Umar A. R. , Wahlich Charlotte , Fortescue Rebecca , Cook Derek G. , Knightly Rachel , Harris Tess 
Published: October 2020

AbstractBackgroundStep-count monitors (pedometers, body-worn trackers and smartphone applications) can increase walking, helping to tackle physical inactivity. We aimed to assess the effect of step-count monitors on physical activity (PA) in randomised controlled trials (RCTs) amongst community-dwelling adults; including longer-term effects, differences between step-count monitors, and between intervention components.MethodsSystematic literature searches in seven databases identified RCTs in healthy adults, or those at risk of disease, published between January 2000–April 2020. Two reviewers independently selected studies, extracted data and assessed risk of bias. Outcome was mean differences (MD) with 95% confidence intervals (CI) in steps at follow-up between treatment and control groups. Our preferred outcome measure was from studies with follow-up steps adjusted for baseline steps (change studies); but we also included studies reporting follow-up differences only (end-point studies). Multivariate-meta-analysis used random-effect estimates at different time-points for change studies only. Meta-regression compared effects of different step-count monitors and intervention components amongst all studies at ≤4 months.ResultsOf 12,491 records identified, 70 RCTs (at generally low risk of bias) were included, with 57 trials (16,355 participants) included in meta-analyses: 32 provided change from baseline data; 25 provided end-point only. Multivariate meta-analysis of the 32 change studies demonstrated step-counts favoured intervention groups: MD of 1126 steps/day 95%CI [787, 1466] at ≤4 months, 1050 steps/day [602, 1498] at 6 months, 464 steps/day [301, 626] at 1 year, 121 steps/day [− 64, 306] at 2 years and 434 steps/day [191, 676] at 3–4 years. Meta-regression of the 57 trials at ≤4 months demonstrated in mutually-adjusted analyses that: end-point were similar to change studies (+ 257 steps/day [− 417, 931]); body-worn trackers/smartphone applications were less effective than pedometers (− 834 steps/day [− 1542, − 126]); and interventions providing additional counselling/incentives were not better than those without (− 812 steps/day [− 1503, − 122]).ConclusionsStep-count monitoring leads to short and long-term step-count increases, with no evidence that either body-worn trackers/smartphone applications, or additional counselling/incentives offer further benefit over simpler pedometer-based interventions. Simple step-count monitoring interventions should be prioritised to address the public health physical inactivity challenge.Systematic review registrationPROSPERO numberCRD42017075810.
First detection and molecular characterisation of pseudocowpox virus in a cattle herd in Zambia
Authors: Ziba Maureen Wakwamba , Chitala Chanda , Settypalli Tirumala Bharani K. , Mumba Malama , Cattoli Giovanni , Fandamu Paul , Lamien Charles Euloge 
Published: October 2020

Abstract
Background
Pseudocowpox virus (PCPV) of the genus Parapoxvirus in the family Poxviridae causes pseudocowpox in cattle worldwide and presents a zoonotic concern. Most poxviruses produce diseases of similar clinical signs in affected animals, which are impossible to differentiate clinically or by serology. It is, therefore, vital to use molecular assays to rapidly identify the causative agents of poxvirus infections. This study aimed to detect, diagnose, and characterize the causative agent of pox-like skin lesions in a cattle herd in Zambia, initially suspected to be infected with Lumpy Skin Disease virus.

Methods
We used a High-Resolution Melting (HRM) analysis assay to detect the PCPV genome and sequenced the major envelope protein (B2L gene) for comparative sequence and phylogenetic analysis.

Results
Our field investigations showed cattle presenting atypical skin lesions and high morbidity within the herd. The laboratory diagnosis, based on the HRM assay revealed PCPV DNA in the samples. Phylogenetic and comparative sequence analyses confirmed PCPV in the samples and revealed genomic differences between samples collected in 2017 and 2018 from the same farm.

Conclusion
Our work is the first documented report of PCPV in Zambia. It shows the strength of molecular methods to diagnose pox-like infections in cattle and discriminate between diseases causing similar clinical signs. This rapid and accurate diagnosis improves the response time for more accurate veterinary interventions.
RETRACTED ARTICLE: The effect of early oral stimulation with breast milk on the feeding behavior of infants after congenital cardiac surgery
Authors: Yu Xian-Rong , Huang Shu-Ting , Xu Ning , Wang Li-Wen , Wang Zeng-Chun , Cao Hua , Chen Qiang 
Published: October 2020

Abstract
Objective
To investigate the effect of early oral stimulation with breast milk on the feeding behavior of infants after congenital cardiac surgery.

Methods
Infants with congenital heart disease were randomly divided into the breast milk oral stimulation group (n = 23), physiological saline oral stimulation group (n = 23) and control group (n = 23). Debra Beckman’s oral exercise program was used with breast milk and physiological saline in the breast milk oral stimulation group and the physiological saline oral stimulation group, respectively. The time oral feeding and total oral nutrition were started, the length of intensive care unit (ICU) stay and hospital stay, weight and the complications at discharge were recorded for each group and statistically analyzed.

Results
The time oral feeding and total oral nutrition were started and the length of ICU stay and hospital stay were significantly less in the breast milk oral stimulation group and physiological saline oral stimulation group than in the control group (P < 0.05). There were no significant differences in other indicators between the breast milk oral stimulation group and the physiological saline oral stimulation group, except for the time total oral nutrition began (P < 0.05). However, there were no significant differences in weight or complications at discharge among the three groups (P > 0.05).

Conclusion
Early oral stimulation exercises with breast milk can help infant patients quickly recover total oral nutrition and reduce the length of ICU and hospital stay after cardiac surgery.
Factor XII in PMM2-CDG patients: role of N-glycosylation in the secretion and function of the first element of the contact pathway
Authors: López-Gálvez Raquel , de la Morena-Barrio María Eugenia , López-Lera Alberto , Pathak Monika , Miñano Antonia , Serrano Mercedes , Borgel Delphine , Roldán Vanessa , Vicente Vicente , Emsley Jonas , Corral Javier 
Published: October 2020

Abstract
Background
Congenital disorders of glycosylation (CDG) are rare diseases with impaired glycosylation and multiorgan disfunction, including hemostatic and inflammatory disorders. Factor XII (FXII), the first element of the contact phase, has an emerging role in hemostasia and inflammation. FXII deficiency protects against thrombosis and the p.Thr309Lys variant is involved in hereditary angioedema through the hyperreactivity caused by the associated defective O-glycosylation. We studied FXII in CDG aiming to supply further information of the glycosylation of this molecule, and its functional and clinical effects. Plasma FXII from 46 PMM2-CDG patients was evaluated by coagulometric and by Western Blot in basal conditions, treated with N-glycosydase F or activated by silica or dextran sulfate. A recombinant FXII expression model was used to validate the secretion and glycosylation of wild-type and variants targeting the two described FXII N-glycosylation sites (p.Asn230Lys; p.Asn414Lys) as well as the p.Thr309Lys variant.

Results
PMM2-CDG patients had normal FXII levels (117%) but high proportions of a form lacking N-glycosylation at Asn414. Recombinant FXII p.Asn230Lys, and p.Asn230Lys&p.Asn414Lys had impaired secretion and increased intracellular retention compared to wild-type, p.Thr309Lys and p.Asn414Lys variants. The hypoglycosylated form of PMM2-CDG activated similarly than FXII fully glycosylated. Accordingly, no PMM2-CDG had angioedema. FXII levels did not associate to vascular events, but hypoglycosylated FXII, like hypoglycosylated transferrin, antithrombin and FXI levels did it.

Conclusions
N-glycosylation at Asn230 is essential for FXII secretion. PMM2-CDG have high levels of FXII lacking N-glycosylation at Asn414, but this glycoform displays similar activation than fully glycosylated, explaining the absence of angioedema in CDG.
High-throughput approaches for precision medicine in high-grade serous ovarian cancer
Authors: Govindarajan Meinusha , Wohlmuth Christoph , Waas Matthew , Bernardini Marcus Q. , Kislinger Thomas 
Published: October 2020

AbstractHigh-grade serous carcinoma (HGSC) is the most prevalent and aggressive subtype of ovarian cancer. The large degree of clinical heterogeneity within HGSC has justified deviations from the traditional one-size-fits-all clinical management approach. However, the majority of HGSC patients still relapse with chemo-resistant cancer and eventually succumb to their disease, evidence that further work is needed to improve patient outcomes. Advancements in high-throughput technologies have enabled novel insights into biological complexity, offering a large potential for informing precision medicine efforts. Here, we review the current landscape of clinical management for HGSC and highlight applications of high-throughput biological approaches for molecular subtyping and the discovery of putative blood-based biomarkers and novel therapeutic targets. Additionally, we present recent improvements in model systems and discuss how their intersection with high-throughput platforms and technological advancements is positioned to accelerate the realization of precision medicine in HGSC.
Maximum common property: a new approach for molecular similarity
Authors: Antelo-Collado Aurelio , Carrasco-Velar Ramón , García-Pedrajas Nicolás , Cerruela-García Gonzalo 
Published: October 2020

AbstractThe maximum common property similarity (MCPhd) method is presented using descriptors as a new approach to determine the similarity between two chemical compounds or molecular graphs. This method uses the concept of maximum common property arising from the concept of maximum common substructure and is based on the electrotopographic state index for atoms. A new algorithm to quantify the similarity values of chemical structures based on the presented maximum common property concept is also developed in this paper. To verify the validity of this approach, the similarity of a sample of compounds with antimalarial activity is calculated and compared with the results obtained by four different similarity methods: the small molecule subgraph detector (SMSD), molecular fingerprint based (OBabel_FP2), ISIDA descriptors and shape-feature similarity (SHAFTS). The results obtained by the MCPhd method differ significantly from those obtained by the compared methods, improving the quantification of the similarity. A major advantage of the proposed method is that it helps to understand the analogy or proximity between physicochemical properties of the molecular fragments or subgraphs compared with the biological response or biological activity. In this new approach, more than one property can be potentially used. The method can be considered a hybrid procedure because it combines descriptor and the fragment approaches.
Influence of X-ray computed tomography (CT) exposure and reconstruction parameters on positron emission tomography (PET) quantitation
Authors: Ho Shon Ivan , Reece Christopher , Hennessy Thomas , Horsfield Megan , McBride Bruce 
Published: October 2020

Abstract
Background
The CT of PET CT provides diagnostic information, anatomic localisation and attenuation correction (AC). When only AC is required, very lose dose CT is desirable. CT iterative reconstruction (IR) improves image quality with lower exposures however there is little data on very low dose IR CT for AC of PET. This work assesses the impact of CT exposure and reconstruction algorithm on PET voxel values.

Method
An anthropomorphic torso phantom was filled with physiologically typical [18]F concentrations in heart, liver and background compartments. A 17-mm-diameter right lung “tumour” filled with [18]F was included (surrounding lung contained no 18[F]). PET was acquired followed by 24 CT acquisitions with varying CT exposures (15–50 mAs, 80–120 kVp, pitch 0.671 or 0.828). Each CT was reconstructed twice using filtered back projection (FBP) or IR and these used for AC of PET. The reference PET reconstruction (RR) used CT acquired at 50 mAs, 120 kVp, pitch 0.828, IR, all others were test PET reconstructions (TR). Regions of interest (ROIs) were drawn in the liver, soft tissue and over “tumour” on each TR and compared with the RR. Voxel values in each TR were compared to the RR using a paired t test and by calculating which and what proportion of voxels in each TR differed by a quantitatively significant difference (QSD) from the RR.

Results
TRs reconstructed using lower dose CTs underestimated mean and maximum ROI activity relative to the RR; greater with IR than FBP. Once CT dose index (CTDI) increased to 1 mGy, differences were less than QSD. On voxel analysis, all TRs were significantly different to the RR (p < 0.0001). TRs reconstructed at the lowest CT exposure with IR had 6% of voxels that differed by greater than QSD. Differences were reduced with increasing CTDI and FBP reconstruction. Voxels which exceeded the QSD were spatially localised to regions of high activity, interfaces between different attenuation and areas of CT beam hardening.

Conclusions
Very low dose CT exposures are feasible for accurate PET AC. Scanner- and reconstruction-specific validation should be employed prior very low dose CT AC for PET.
Faith-based organizations: humanitarian mission or religious missionary
Authors: Khafagy Riham Ahmed 
Published: October 2020

AbstractThis paper analyzes Islamic FBOs’ humanitarian approaches, programs, and challenges. Politicalized religious interpretations are also on board to investigate their missionary aspects. I design my argument based on Michael Barnett and Janice Grass Stein’s assumption on the impact of social constructions on establishing sacred and secular concepts and spaces. Thus, I study the UK-based Islamic Relief Worldwide (IRW) and the Kuwaiti Direct Aid Society (DAS) to examine the influence of their social settings on their humanitarian experiences. My question is “do different social settings shape various humanitarian approach, although of sharing the same religious mission?” I argue that Islamic rules encourage Muslims to be religiously committed to paying charity and showing human and religious solidarity. In this regard, flexible Islamic Fiqh (jurisprudence) allows Muslima to set various socially constructed implementations of these religious commitments. Humanitarian relief is not an exception in this regard. Therefore, Islamic FBOs lay down on a continuum based on their socially constructed models which reflect different interpretations of religious texts and their applications to understanding societal issues as well as various employed strategies of these civil society actors.
An analysis of movement patterns in mass casualty incident simulations
Authors: Tolg Boris , Lorenz Juergen 
Published: October 2020

Abstract
Background
Mass casualty incidents (MCI) such as train or bus crashes, explosions, collapses of buildings, or terrorist attacks result in rescue teams facing many victims and in huge challenges for hospitals. Simulations are performed to optimize preparedness for MCI. To maximize the benefits of MCI simulations, it is important to collect large amounts of information. However, a clear concept and standardization of a data-driven post-exercise evaluation and debriefing are currently lacking.

Methods
GPS data loggers were used to track the trajectories of patients, medics, and paramedics in two simulated MCI scenarios using real human actors. The distribution of patients over the treatment area and their time of arrival at the hospital were estimated to provide information on the quality of triage and for debriefing purposes.

Results
The results show the order in which patients have been treated and the time for the individual arrivals as an indicator for the triage performance. The distribution of patients at the accident area suggested initial confusion and unclear orders for the placement of patients with different grades of injury that can be used for post-exercise debriefing. The dynamics of movement directions allowed to detect group behavior during different phases of the MCI.

Conclusions
Results indicate that GPS data loggers can be used to collect precise information about the trajectories of patients and rescue teams at an MCI simulation without interfering with the realism of the simulation. The exact sequence of the deliverance of patients of different triage categories to their appropriate destinations can be used to evaluate team performance for post-exercise debriefing. Future MCI simulations are planned to validate the use of GPS loggers by providing “hot-debrief” immediately after the MCI simulation and to explore ways in which group detection can provide relevant information for post-exercise evaluations

Trial registration
Not applicable.
An Ethics Debate for the Ages: American Individualism and the Dilemma of the Healthy Carrier
Authors: Nixon Kari 
Published: October 2020

AbstractMany public health ethics debates are construed as the rights of the collective versus the rights of the individual. This essay demonstrates that in the context of diseases which are transmitted by healthy carriers, the issue is more complex than this. Instead of arguing about competing rights, this essay argues that such debates are first about competing visions of reality, in which the individual is asked to substitute a collective understanding of their body for their own personal experience of their body. Understanding this first layer of the ethics debate in such healthy carrier situations allows us to redirect persuasive energies, moving away from a beginning-point of compliance to one of understanding, which may ultimately find a more willing public audience.
Who Counts? Old Age in COVID Times
Authors: Thrailkill Jane F. 
Published: October 2020

Abstract
People over sixty-five have been singled out as a uniquely vulnerable risk group for the novel coronavirus. Yet the discourse of risk obscures (and exacerbates) socially created dangers of congregate care in the United States: poorly paid workers holding down multiple jobs and the endemic “plagues” of loneliness, boredom, and hopelessness. Humorous memes about who counts as old point out structural inequalities, while millions of able-bodied “shut-ins” (due to lockdowns and job losses) may experience forced empathy: fuel for new imaginings about how to care for—and value—elders moving forward.
Public Humanities in the Reconstructed University
Authors: Leonard Sophia , Reiss Benjamin , Antonio Víctor Velázquez , Fitzgerald Makenzie Renee 
Published: October 2020

AbstractColleges and universities that can withstand the fallout of the COVID-19 crisis will need to redouble their efforts to engage students in the kinds of intellectual and social experiences that cannot be attained remotely or in isolation. Public humanities, which promotes collaboration, civic and community engagement, and inter-institutional alliances, can be one such reparative force for the reconstructed university. This essay describes the work of graduate student researchers in an interdisciplinary public humanities seminar at Emory University who partnered with a large regional theater on a project involving dramaturgy and audience engagement for a spring 2020 production of Lynn Nottage’s play Sweat (first performed in 2015). The graduate seminar and the project—both before and in the wake of the COVID-19 outbreak—offer a compelling model for critical humanistic pedagogy and research that counteracts the isolation and insularity exacerbated by the pandemic.
The multilateral security organizations at stake. NATO, OSCE and the Covid-19 emergency: an opportunity into the crisis?
Authors: Zichi Gian Lorenzo 
Published: October 2020

The Coronavirus outbreak showed how nobody was prepared to this crisis and to its economic, social and political implications which now represent the main challenge for political actors. However, if the measures taken by national states to curb the sanitary emergency seem to have partially restored their capacity to address the events, the Covid-19 has struck a significant blow to the already fragile multilateral system, as exemplified by the allegations – some of them based on coherent elements of criticism, other with less objective basis and misleading – to the World Health Organization (WHO). To better investigate the impact of this unprecedented crisis on the international institutions and its implications on security, the present article aims first to shed light on how two important organizations as the North Atlantic Treaty Organization (NATO) and the Organization for Security and Co-operation in Europe (OSCE), have reacted and are acting to this crisis: an aspect just partially covered by the public media and that deserves to be better explored to avoid misleading interpretations. Secondly, trying to offer to the national stakeholders and public opinions a useful way to look on the Covid-19’s impact on these forums, the analysis will also reflect on the possibility that this crisis could be turn by the organizations into an opportunity to relaunch themselves and become more aware of the other elements of concern as health risks, climate change and migration which, even not strictly related with the conventional interpretation of security, are posing undeniable aspects of concern. In front of the contradiction between the emerging of complex global challenges and the deteriorating of the multilateral order, this crisis should foster organizations and states to find a new reason to cooperate in answering to the future global threats, recognizing that a better security is possible only through a comprehensive approach.