bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endovascular Embolization of a Paracavernous Arteriovenous Fistula Through a Cortical Venous Access: 2-Dimensional Operative Video
Authors: Akamatsu Yosuke , Gomez-Paz Santiago , Moore Justin M , Thomas Ajith J , Ogilvy Christopher S 
Published: July 2020

Abstract
We present the case of a 62-yr-old female with a right bulging eye and intermittent headaches. A T2 weighted magnetic resonance image revealed a dilated serpiginous vessel in the right orbit and abnormal flow voids lateral to the orbital apex. The right internal carotid contrast injection demonstrated a dural arteriovenous fistula (dAVF) fed by the ophthalmic artery and drainage into the ipsilateral superficial middle cerebral veins (SMCVs) and the basal vein of Rosenthal without opacification of the cavernous sinus. A fistulous pouch was identified anterolateral to the carotid siphon. The venous phase of the left internal carotid injection demonstrated the bilateral cavernous sinuses, suggesting no involvement of the cavernous sinus with the fistula. Concerning the risk of future hemorrhagic events, endovascular treatment was recommended. Considering the robust connection of the cortical draining vein with the superior sagittal sinus (SSS), a transvenous embolization was performed. The lesion was accessed through the SSS and the right SMCV and embolized with platinum coils, resulting in complete fistula obliteration without any complications. The SMCVs can drain into paracavernous venous structure, which independently presents lateral to cavernous sinus.
1,2
Because incomplete embolization of this fistula through cavernous sinus can alter the shunt flow toward cerebral veins, we did not get into the fistula site through the cavernous sinus using conventional methods. Transvenous access through a cortical bridging vein is an efficient alternative for endovascular embolization of paracavernous dAVFs. Patient approval and consent was obtained prior to the procedure and for submission of this article.
Percutaneous management of coronary bifurcation lesions: current perspective
Authors: Wassef Anthony W.A. , Liu Shuangbo , Yanagawa Bobby , Verma Subodh , Cheema Asim N. 
Published: July 2020

Purpose of review
Coronary artery disease affecting bifurcations poses a challenge for percutaneous intervention. Several techniques and strategies for percutaneous management of bifurcation lesions have been described in the literature with variable data available for outcomes. In this review, we provide an overview of the strategies and techniques used for percutaneous intervention of bifurcation lesions with an update of recent technical developments and clinical evidence.

Recent findings
The coronary bifurcation lesions of both left main and other coronary segments are best treated with a provisional stenting strategy where main branch is treated with a stent placement and side branch intervention reserved for angiographically or physiologically determined hemodynamically significant residual stenosis despite application of a proximal stent optimization technique. When a provisional stent strategy is not likely to be successful due to anatomic or morphologic lesion characteristics and a large side branch or distal left main bifurcation is involved, an upfront bifurcation stenting strategy with double kissing crush technique may provide the optimum results. Coronary imaging and fractional flow determination may guide lesion specific management, facilitate device selection and improve clinical outcomes for percutaneous therapy for bifurcation lesions.

Summary
Despite advances in technology and procedural techniques, percutaneous intervention of coronary bifurcation lesions remains challenging and associated with higher adverse outcomes compared to non bifurcation lesions. Among the several bifurcation strategies, a provisional stenting approach is preferred for technical simplicity and better long term outcomes. Double kissing crush technique provides superior clinical results and should be preferred when a two stent strategy is indicated. Use of coronary imaging and physiology assessment should be incorporated in the algorithm of bifurcation interventions for greater technical and clinical success.
Effect of microinterventional endocapsular nucleus disassembly using centripetal loop fragmentation on refractive outcomes after cataract surgery
Authors: Roper Gerald J. , Hoffer Kenneth J. , Pamnani Ravinder D. 
Published: July 2020

Purpose:
To evaluate the refractive impact of centripetal fragmentation using the miLOOP system for nucleus disassembly, which minimizes lens zonulocapsular instability associated with endocapsular lens manipulation.

Setting:
Private practice, Batesville, Indiana, USA.

Design:
Retrospective comparative consecutive series.

Methods:
Refractive outcomes were compared for consecutive patients who underwent cataract surgery and intraocular lens implantation before and after the introduction of a microinterventional endocapsular nucleus disassembly technique using the miLOOP system. Eyes with a history of previous surgery or ocular comorbidities were excluded. The primary outcome was the median absolute error (MedAE) from the preoperative predicted refraction. Secondary outcomes included corrected (CDVA) and uncorrected distance visual acuity (UDVA) and the proportion of eyes within predicted diopter (D) ranges.

Results:
A total of 118 eyes of 79 patients were analyzed, with 69 eyes undergoing conventional nuclear disassembly and 49 eyes receiving the microinterventional technique. The MedAE for eyes using conventional nucleus disassembly vs the microinterventional technique was 0.191 D vs 0.107 D, respectively (P = .002). For CDVA and UDVA, the microinterventional approach resulted in a trend toward a higher proportion of eyes achieving acuities better than 20/30, 20/25, and 20/20 compared with conventional techniques. The microinterventional approach showed a trend toward more eyes achieving less than ±0.25 D and ±0.50 D of prediction error from the predicted diopter range.

Conclusions:
Microinterventional nuclear disassembly might improve refractive outcomes by reducing refractive prediction error.
Cardiac manifestations in patients with classical or cardiac subtype of Fabry disease
Authors: Wang Wei-Ting , Sung Shih-Hsien , Liao Jo-Nan , Hsu Ting-Rong , Niu Dau-Ming , Yu Wen-Chung 
Published: July 2020

Background:
Fabry disease (FD) is an X-linked lysosomal storage disorder engendered by a deficiency of the enzyme α-galactosidase A, leading to systemic accumulation of glycolipids. Studies have reported that the cardiac subtype of FD has a later onset and minimal extracardiac involvement. However, whether the severity of cardiac involvement differs between the classic and cardiac subtypes of FD remains unclear.

Methods:
We enrolled consecutive patients with classic FD (n = 22; median age [25th–75th percentile], 47.0 [32.75–56.25] years; men, 72.7%) as well as age- and sex-matched patients with a later-onset cardiac subtype of FD who were selected from our cohort of patients with IVS4 919G>A mutation. FD was diagnosed on the basis of clinical symptoms/signs and pedigree screening of index case, plasma α-galactosidase activity, and molecular analysis. Data on clinical manifestations, laboratory findings, and echocardiogram findings were collected before enzyme replacement treatment. Disease severity was evaluated using the Mainz Severity Score Index score.

Results:
All female patients demonstrated heterozygous mutations, with five, one, and four of them showing normal α-galactosidase activity, classic FD, and cardiac subtype of FD, respectively. The distributions of left ventricular performance indices and comorbidities, including hypertension, diabetes mellitus, and dyslipidemia, were similar between the two groups. Moreover, MSSI cardiovascular scores did not differ significantly between the groups (classic vs cardiac subtype, 10.0 [2.0–12.5] vs 10.5 [9.0–15.25]; p = 0.277).

Conclusion:
Cardiac manifestations are similar between patients with classic and cardiac subtype of FD.
Effects of Patient Activation Intervention on Chronic Diseases: A Meta-Analysis
Authors: LIN Mei-Yu , WENG Wei-Shih , APRILIYASARI Renny Wulan , VAN TRUONG Pham , TSAI Pei-Shan 
Published: July 2020

ABSTRACT

Background
Patient activation has been described as a potential strategy to improve chronic disease self-management. However, the effects of patient activation interventions on psychological and behavioral outcomes have not been systematically evaluated.

Purpose
This study was designed to evaluate the effects of patient activation interventions on physiological, psychological, behavioral, and health-related quality of life outcomes in patients with chronic diseases.

Methods
We systematically searched four databases (PubMed, Cochrane, CINAHL, and Embase) from inception to September 1, 2017. We identified English- and Chinese-language published reports of randomized controlled trials that evaluated the effects of patient activation interventions for adults with chronic diseases. Study selection, data extraction, and quality assessment were performed by two reviewers independently. We summarized the intervention effects with Hedges's g values and 95% confidence intervals using a random-effects model. We used the Cochrane Handbook to assess the methodological quality of the randomized controlled trials.

Results
Twenty-six randomized controlled trials were included in the qualitative synthesis and meta-analysis. In terms of overall study quality, most of the included studies were affected by performance and detection bias. Patient activation interventions produced significant effects on outcomes related to physiological, psychological, behavioral, and health-related quality of life in the context of chronic diseases. The following effect sizes were obtained: (a) physiological, namely, glycated hemoglobin = −0.31 (p < .01), systolic blood pressure = −0.20 (p < .01), diastolic blood pressure = −0.80 (p = .02), body weight = −0.12 (p = .03), and low-density lipoprotein = −0.21 (p = .01); (b) psychological, namely, depression = −0.16 (p < .01) and anxiety = −0.25 (p = .01); (c) behavioral, namely, patient activation = 0.33 (p < .01) and self-efficacy = 0.57 (p < .01); and (d) health-related quality of life = 0.25 (p = .01).

Conclusions
Patient activation interventions significantly improve patients' physiological, psychosocial, and behavioral health statuses. Healthcare providers should implement patient activation interventions that tailor support to the individual patients' level of patient activation and strengthen the patients' role in managing their healthcare to improve chronic-disease-related health outcomes.
Web-based Conferencing: Tips, Tricks, and Scenario-based Best Practices for Clinicians During a Pandemic Crisis
Authors: Catanzano Tara M. , Nandwana Sadhna B. , Folio Les R. 
Published: July 2020

Abstract
This article will familiarize the reader with useful tools and trouble-shooting tips for web-based conferencing. Radiology-based scenarios for web conferencing are also provided.
Sinus Pericranii in Posterior Cranial Vault Distraction
Authors: Tyrell Richard , Limoges Natalie , Kestle John , Gociman Barbu , Siddiqi Faizi 
Published: July 2020

Abstract
Anomalous venous connections between the extracranial and intracranial systems are relatively rare. These connections are also known as sinus pericranii (SP) have been reported previously in the setting of various cranial malformations including craniosynostosis. Angiography may be useful in the diagnosis of SP also allowing for differentiation of the dominance of the venous systems. Several methods have been described in the treatment of SP. In isolated cases both endovascular and open approaches have been successful in the treatment of SP. In cases wherein there is synostosis present, both single- and multiple-staged operations have been described. In this article, we describe 2 cases of posterior cranial distraction in the setting of sinus peri cranii.
Diagnosing Pathologic Complete Response in the Breast After Neoadjuvant Systemic Treatment of Breast Cancer Patients by Minimal Invasive Biopsy
Authors: Heil Joerg , Pfob André , Sinn Hans-Peter , Rauch Geraldine , Bach Paul , Thomas Bettina , Schaefgen Benedikt , Kuemmel Sherko , Reimer Toralf , Hahn Markus , Thill Marc , Blohmer Jens-Uwe , Hackmann John , Malter Wolfram , Bekes Inga , Friedrichs Kay , Wojcinski Sebastian , Joos Sylvie , Paepke Stefan , Ditsch Nina , Rody Achim , Große Regina , van Mackelenbergh Marion , Reinisch Mattea , Karsten Maria , Golatta Michael ,   for the RESPONDER Investigators
Published: July 2020

Objective:
We evaluated the ability of minimally invasive, image-guided vacuum-assisted biopsy (VAB) to reliably diagnose a pathologic complete response in the breast (pCR-B).

Summary Background Data:
Neoadjuvant systemic treatment (NST) elicits a pathologic complete response in up to 80% of women with breast cancer. In such cases, breast surgery, the gold standard for confirming pCR-B, may be considered overtreatment.

Methods:
This multicenter, prospective trial enrolled 452 women presenting with initial stage 1-3 breast cancer of all biological subtypes. Fifty-four women dropped out; 398 were included in the full analysis. All participants had an imaging-confirmed partial or complete response to NST and underwent study-specific image-guided VAB before guideline-adherent breast surgery. The primary endpoint was the false-negative rate (FNR) of VAB-confirmed pCR-B.

Results:
Image-guided VAB alone did not detect surgically confirmed residual tumor in 37 of 208 women [FNR, 17.8%; 95% confidence interval (CI), 12.8–23.7%]. Of these 37 women, 12 (32.4%) had residual DCIS only, 20 (54.1%) had minimal residual tumor (<5 mm), and 19 of 25 (76.0%) exhibited invasive cancer cellularity of ≤10%. In 19 of the 37 cases (51.4%), the false-negative result was potentially avoidable. Exploratory analysis showed that performing VAB with the largest needle by volume (7-gauge) resulted in no false-negative results and that combining imaging and image-guided VAB into a single diagnostic test lowered the FNR to 6.2% (95% CI, 3.4%–10.5%).

Conclusions:
Image-guided VAB missed residual disease more often than expected. Refinements in procedure and patient selection seem possible and necessary before omitting breast surgery.
Dynamic coupling between the COVID epidemic timeline and the behavioral response to PAUSE in New York State counties
Authors: Rǎdulescu Anca , Ballard Shelah , Linton Johnathan , Gonzalez Kaitlyn 
Published: July 2020

AbstractBy many expert opinions, the COVID 19 epidemic is still much in its developing stages. While awaiting for effective clinical answers for the outbreak, the best approach remains that of social distancing. This raises a few crucial questions related to the extent to which social distancing measures were (1) well timed, (2) necessary and (3) efficient. By investigating correlations between epidemic measures such as daily infection rate, and social mobility measures (as reported by Apple and Google), our study aims to establish whether data identifies social distancing measures as a primary player in controlling the outbreak in New York State.
Cigarette Smoke Activates NOTCH3 to Promote Goblet Cell Differentiation in Human Airway Epithelial Cells
Authors: Bodas Manish , Moore Andrew R. , Subramaniyan Bharathiraja , Georgescu Constantin , Wren Jonathan D. , Freeman Willard M. , Brown Brent R. , Metcalf Jordan P. , Walters Matthew S. 
Published: July 2020

AbstractChronic obstructive pulmonary disease (COPD) is the 3rd leading cause of death in the United States and is primarily caused by cigarette smoking. Increased numbers of mucus-producing secretory (“goblet”) cells defined as goblet cell metaplasia or hyperplasia (GCMH), contributes significantly to COPD pathophysiology. The objective of this study was to determine whether NOTCH signaling regulates goblet cell differentiation in response to cigarette smoke. Primary human bronchial epithelial cells (HBECs) from nonsmokers and COPD smokers were differentiatedin vitroon air-liquid interface and exposed to cigarette smoke extract (CSE) for 7 days. NOTCH signaling activity was modulated using (1) the NOTCH/γ-secretase inhibitor Dibenzazepine (DBZ), (2) lentiviral over-expression of the NOTCH3-intracellular domain (NICD3) or (3) NOTCH3-specific siRNA. Cell differentiation and response to CSE were evaluated by qPCR, Western blotting, immunostaining and RNA-Seq. We found that CSE exposure of nonsmoker airway epithelium induced goblet cell differentiation characteristic of GCMH. Treatment with DBZ suppressed CSE-dependent induction of goblet cell differentiation. Furthermore, CSE induced NOTCH3 activation, as revealed by increased NOTCH3 nuclear localization and elevated NICD3 protein levels. Over-expression of NICD3 increased the expression of goblet cell associated genes SPDEF and MUC5AC, whereas NOTCH3 knockdown suppressed CSE-mediated induction of SPDEF and MUC5AC. Finally, CSE exposure of COPD airway epithelium induced goblet cell differentiation in a NOTCH3-dependent manner. These results identify NOTCH3 activation as one of the important mechanisms by which cigarette smoke induces goblet cell differentiation, thus providing a novel potential strategy to control GCMH-related pathologies in smokers and patients with COPD.
A transient contact position prediction method for worn tooth profile under dry running conditions
Authors: Zhang Shengnan , Sun Z.l. , Yu Zhenliang , Guo Fanyi 
Published: July 2020

Purpose
The purpose of this paper is to establish a transient contact position prediction method of gears at the meshing point based on the equivalent contact model.

Design/methodology/approach
In this method, the contacting surface proﬁles are constantly updated by changing the pressure angle and the chord tooth thickness, which has a direct connection with the equivalent base circle radius. According to the equivalent base circle radius, the equivalent pressure angle at the pitch circle and equivalent pitch point can be calculated. The equivalent contacting surface proﬁle is determined by the equivalent pressure angle at the pitch circle; for each meshing point, there is one equivalent pressure angle at the pitch circle. Therefore, each meshing point can be regarded as a point on the equivalent contacting surface proﬁle.

Findings
The model is applicable to find out the contact position after a series of meshing cycles through the law of pressure angle change and intentionally kept as simple as possible with the aim to be used in further study of gear flanks at the point of the actual contact.

Practical implications
The results of the experiment are applied to the equivalent contact model to describe the transient contact position and assess the model accuracy.

Originality/value
The determination of the contact position of the worn tooth profile provides the action points of the force for the study of the contact fatigue.
Social cohesion vs COVID-19
Authors: Dayrit Manuel M. , Mendoza Ronald Umali 
Published: July 2020

PurposeThe control of particularly virulent communicable diseases such as COVID-19 can be considered a global public good. Unabated contagion, both within and across borders, can result in a global public bad. More effective control – such as by flattening the epidemiological curve – could prevent severe social and economic disruption by allowing domestic health and social protection systems to more adequately respond to the health crisis. This article elaborates on some of the main elements of counter COVID-19 responses, drawing on emerging international good practices. While a full evaluation of policy effectiveness is still forthcoming, it is critical to review and synthesize the emerging lessons and evidence even this early.Design/methodology/approachThis article reviews the international good practices in counter COVID-19 responses across countries.FindingsConcerted efforts across borders, such as by sharing data and collaborating in research and by coordinating international support for countercyclical economic and health responses at the national level, are some of the options for countering COVID-19 at the international level. Within countries, more inclusive social protection and health systems, combined with countercyclical economic policies, and concerted behavioral changes tend to produce more effective collective action against the spread of the disease.Research limitations/implicationsThis study is based on a review of emerging responses to the health crisis.Practical implicationsThe policies and practices reviewed in this paper could feed into better-informed crisis responses to COVID-19 and other types of health shocks.Originality/valueThis study is among the first general reviews of policy responses to the COVID-19 health crisis.
The implications of the Brexit from EU and bitcoin
Authors: Al-Tawil Tareq Na'el , Younies Hassan 
Published: July 2020

Purpose
The purpose of this paper is to tackle the most pressing issues confronting global anti-money laundering (AML) efforts, particularly, the implications of the Brexit from EU and the increasing association of bitcoin and cryptocurrencies with crimes.

Design/methodology/approach
This paper will evaluate the implications of Brexit to AML efforts and the threat that cryptocurrencies like bitcoin pose to the financial system.

Findings
Instead of banning trade and other transactions using BTC and other cryptocurrencies, financial experts, with the able assistance of IT and mining experts, from all over the world need to convene and tailor an effective regulatory framework. Solid cooperation among the international community, supported by unitary standards and procedures, will help boost the worlds AML/combatting the financing of terrorism (CFT) efforts. As an added bonus, effective regulation, monitoring and control can facilitate more efficient tax collection.

Originality/value
Recommendations were advanced about the future of AML/CFT efforts and the need for internationally holistic approaches in combatting these twin scourges on all economies.
Chronicles of one woman’s journey towards well-being: identity part 2
Authors: Mullen Jo 
Published: July 2020

Purpose
The purpose of this paper is to share the experiences and reflections of one woman’s journey towards well-being.

Design/methodology/approach
A narrative approach has been taken to structure reflections based on lived experience.

Findings
Reflections are offered based on a personal journey towards well-being.

Originality/value
This paper adds to the accounts of the lived experience of the journey towards well-being, and as such, contributes to the understanding of the process of rebuilding a life.