bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance of Agriculture in Uttar Pradesh-A District-level Analysis
Authors: Kumari Reena 
Published: December 2020

The growth of agriculture is prerequisite for overall development of Indian economy. It contributes significantly to the export earnings and affects the performance of other sectors of the economy through forward and backward linkages. The present paper analyses district and regional level disparity in agriculture development in Uttar Pradesh on a number of agricultural parameters. It uses UNDP methodology (subsequently used by a number of others) to standardize various indicators for agricultural attainment in the state of Uttar Pradesh using 13 agricultural development indicators. A composite index has been constructed at the district level and also regional level for two cross-section years 1990-91 and 2008-09. The relative variations and changes in ranks of different districts have been computed during the period under consideration. Evidence shows existence of high and persistent inter-state disparity in agriculture in the state over the years.Â The transformation of some districts from the level of relatively underperformer to the rank of better performer and vice versa has been witnessed and explained. The findings encourage the authors to conclude that a more determined effort on the part of the policy makers is needed if the development policy has to be made truly inclusive.
Ischiofemoral Impingement Syndrome Secondary to Arteriovenous Malformation of the Quadratus Femoris
Authors: Singaravadivelu Vaidyanathan , Abraham Alvinson William 
Published: December 2020

Case:
Ischiofemoral impingement syndrome (IFIS), an unusual presentation of hip pain, is frequently missed in clinical practice. We report a case of a 27-year-old man with complaints of gradual onset nonprogressive right gluteal pain with hip movement restriction for the past 5 years that was not relieved with conservative measures. Right hip magnetic resonance imaging revealed a vascular abnormality of the right quadratus femoris muscle suggestive of IFIS. This abnormal muscle was surgically excised, and its histologic evaluation was remarkable for an arteriovenous malformation.

Conclusion:
The patient's longstanding symptomatic IFIS was ultimately attributed to a rare arteriovenous malformation of the quadratus femoris that resolved with surgical excision.
Cryptococcus magnus Periprosthetic Shoulder Infection
Authors: Baptista Mário , Sevivas Nuno , Ferreira Nuno Vieira , Fardilha Luísa , Varanda Pedro , Mateus Carlos 
Published: December 2020

Case:
We present a 68-year-old diabetic man with a periprosthetic shoulder infection (PSI) by Cryptococcus magnus. The fungus was identified 4 weeks after a revision surgery for a chronic bacterial PSI. Treatment was successful with a 2-week course of intravenous liposomal amphotericin B (5 mg/kg) followed by 6 weeks of fluconazole (200 mg/d).

Conclusion:
To the best of our knowledge, only 2 periprosthetic infections due to Cryptococcus neoformans have been previously reported. This is the first report of cryptococcal involvement of a prosthetic shoulder, and the first identified osteoarticular infection ever by C. magnus.
Effectiveness of oral health education on eight- to ten-year-old school children in rural areas of the Magway Region, Myanmar
Authors: Swe Kyu Kyu , Soe Aung Kyaw , Aung Saw Htun , Soe Htin Zaw 
Published: December 2020

Abstract
Background: Oral diseases are common and widespread around the world. The most common oral diseases are preventable, and early onset is reversible. Myanmar faces many challenges in rendering oral health services, because approximately 70 percent of the total population resides in rural areas. These relate to the availability and accessibility of oral health services. Therefore, oral health education is one key element to prevent oral diseases and to promote oral health.Methods: A quasi-experimental study was carried out at Basic Education Middle Schools in rural areas of Magway Township to study the effectiveness of oral health education on the knowledge and behavior of eight- to ten-year-old school children. A total of 220 school children, 110 from intervention schools and 110 from control schools, participated in this study from 2015 to 2017. Data were collected before and after intervention in the two groups by using a self-administered questionnaire. Tooth brushing method data were collected by direct observation with a checklist. Oral health education was provided at eight weekly intervals for one year. At one and a half years, third-time data collection was done on the intervention group to assess retention. Chi-square test, two samples t-test and one-way repeated measure ANOVA were used for data analysis. The study was approved by the Institutional Review Board of the University of Public Healthin Yangon, Myanmar.Results: There were significant differences between the two groups in four out of five knowledge questions (p<0.05) and all behavior questions (p<0.001) after intervention. A positive effect of oral health education for a period of 45 minutes at eight weekly intervals for one year was found in the intervention group. The intervention had a significant effect on the sustainability of the correct knowledge and behavior of the intervention group although the education session was stopped for six months (p<0.001). Their mean knowledge and behavioral scores at three different points in time were (2.45±1.12 and1.56±0.90) at baseline, (3.79±1.12 and 3.60±1.21) at one year after education and (4.07±0.98 and 3.24±1.31) at six months after cessation of education, respectively. Conclusions: Repeated oral health education was effective in promoting and sustaining oral health knowledge and behavior.
Metapristone (RU486-derivative) inhibits endometrial cancer cell progress through regulating miR-492/Klf5/Nrf1 axis
Authors: Chang Yue , Hao Min , Jia Ru , Zhao Yihui , Cai Yixuan , Liu Yun 
Published: December 2020

Abstract
Background: Endometrial cancer is an invasive gynecological cancer prevalent in the world. The pathogenesis of endometrial cancer is related to multiple levels of regulation, referring to oestrogen, tumor-suppressor gene (e.g. PTEN ) or microRNAs (e.g. miR-23a and miR-29b). Metapristone is a hormone-related drug, which is widely used in clinical treatment of endometrial cancer. However, the underlying regulatory mechanism of metapristone on endometrial cancer is still unclear, especially the regulatory effect on microRNAs. The aim of this study is to investigate the specific molecular mechanism of metapristone regulating microRNAs in the treatment of endometrial cancer. Methods: RL95-2 cells and Ishikawa cells were used as the endometrial cancer models. MiR-492 or si-miR-492 was transfected into RL95-2 cells and Ishikawa cells to explore the role of miR-492 in endometrial cancer. The cell cancer model and mice cancer model were used to confirm the function and mechanism of metapristone affected on endometrial cancer in vitro and in vivo . Mechanically, cell proliferation was monitored using the MTT assay, cell colony formation assay and EdU assay. Luciferase reporter assay was used to identify the downstream target gene of miR492. The protein expression and RNA expression were respectively measured by western blot and qRT-PCR for cell signaling pathway research, subsequently, were verified in the mice tumor model via immunohistochemistry. Results: Metapristone as a kind of hormone-related drug significantly inhibited the endometrial cancer cell growth through regulating cell apoptosis-related gene expression. Mechanically, miR-492 and its target genes Klf5 and Nrf1 were highly expressed in the endometrial cancer cell lines, which promoted cell proliferation and inhibited cell apoptosis. Metapristone decreased the expression of miR-492 and its target genes Klf5 and Nrf1 , leading to endometrial cancer cell growth inhibition in vitro and in vivo . Conclusion: Metapristone inhibited the endometrial cancer cell growth through regulating the cell apoptosis-related signaling pathway and decreasing the expression of miR-492 and its downstream target genes ( Klf5 and Nrf1 ), which provided the theoretical basis in clinical treatment of endometrial cancer.
ASPP2/PP1 complexes maintain the integrity of pseudostratified epithelia undergoing remodelling during morphogenesis
Authors: Royer Christophe , Sandham Elizabeth , Slee Elizabeth , Godwin Jonathan , Veits Nisha , Hathrell Holly , zhou Felix , Leonavicius karolis , Garratt Jemma , Narendra Tanaya , Vincent Anna , Jones Celine , Child Tim , Coward Kevin , Graham Chris , Lu Xin , Srini Shankar 
Published: December 2020

Abstract
During development, pseudostratified epithelia undergo large scale morphogenetic events associated with increased mechanical stress. The molecular mechanisms that maintain tissue integrity in this context are poorly understood. Using a variety of genetic and imaging approaches, we uncover that the ASPP2/PP1 complex ensures proper epiblast and proamniotic cavity architecture via a mechanism that specifically prevents the most apical daughter cells from delaminating apically following cell division events. The ASPP2/PP1 complex achieves this by maintaining the integrity and organisation of the F-actin cytoskeleton at the apical surface of dividing cells. ASPP2/PP1 is also essential during gastrulation in the primitive streak, in somites and in the head fold region, suggesting that this complex is required across a wide range of pseudostratified epithelia during morphogenetic events that are accompanied by intense tissue remodelling and high cell proliferation. Finally, our study also suggests that the interaction between ASPP2 and PP1 is essential to the tumour suppressor function of ASPP2 which may be particularly relevant in the context of tissues that are subject to increased mechanical stress.
Elevated cellular PpIX potentiates sonodynamic therapy in a mouse glioma stem cell-bearing glioma model by downregulating the Akt/NFkB/MDR1 pathway
Authors: Mizobuchi Yoshifumi , Shono Kenji , Yamaguchi Izumi , Nakajima Kohei , Fujiwara Yuri , Fujihara Toshitaka , Kitazato Keiko , Matsuzaki Kazuhito , Uto Yoshihiro , Ulsula Oltea , Saya Hideyuki , Takagi Yasushi 
Published: December 2020

Abstract
Glioblastoma (GBM) has high mortality rates because of extremely therapeutic resistance. During surgical resection for GBM, 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence is conventionally applied to distinguish GBM. However, surgical intervention is insufficient for high invasive GBM. Sonodynamic therapy (SDT) is an emerging and promising approach combined with low-intensity ultrasonication (US) and PpIX as a sonosensitizer for cancer, whereas its efficacy is limited. Based on our previous study that down-regulation of multidrug resistant protein (MDR1) in GBM augmented anti-tumor effects of chemotherapy, we hypothesized that elevation of cellular PpIX levels by down-regulation of MDR1 enhances anti-tumor effects by SDT. In high invasive progeny cells from mouse glioma stem cells (GSCs) and a GSC-bearing mouse glioma model, we assessed the anti-tumor effects of SDT with a COX-2 inhibitor, celecoxib. Down-regulation of MDR1 by celecoxib increased cellular PpIX levels, as well as valspodar, a MDR1 inhibitor and augmented anti-tumor effects of SDT. MDR1 down-regulation via Akt/NF-kB pathway by celecoxib was confirmed, using a NF-kB inhibitor, CAPÉ. Thus, elevation of cellar PpIX by down-regulation of MDR1 via Akt/NF-kB pathway may be crucial to potentiate the efficacy of SDT in a site-directed manner and provide a promising new therapeutic strategy for GBM.
Spatiotemporal evolution analysis of agricultural non-point source pollution risks in Chongqing, China, based on the ITO3dE model and GIS
Authors: ZHU Kang-wen , YANG Zhi-min , HUANG Lei , CHEN Yu-cheng , ZHANG Sheng , XIONG Hai-ling , WU Sheng , LEI Bo 
Published: December 2020

Abstract
To determine the risk state distribution, risk level, and risk evolution situation of agricultural non-point source pollution (AGNPS), we built an ‘Input-Translate-Output’ three-dimensional evaluation (ITO3dE) model that involved 12 factors under the support of GIS and analyzed the spatiotemporal evolution characteristics of AGNPS risks from 2005 to 2015 in Chongqing by using GIS space matrix, kernel density analysis, and Getis-Ord Gi* analysis. Land use changes during the 10 years had a certain influence on the AGNPS risk. The risk values in 2005, 2010, and 2015 were in the ranges of 0.40–2.28, 0.41–2.57, and 0.41–2.28, respectively, with the main distribution regions being the western regions of Chongqing (Dazu, Jiangjin, etc.) and other counties such as Dianjiang, Liangping, Kaizhou, Wanzhou, and Zhongxian. The spatiotemporal transition matrix could well exhibit the risk transition situation, and the risks generally showed no changes over time. The proportions of ‘no-risk no-change’, ‘low-risk no-change’, and ‘medium-risk no-change’ were 10.86%, 33.42%, and 17.25%, respectively, accounting for 61.53% of the coverage area of Chongqing. The proportions of risk increase, risk decline, and risk fluctuation were 13.45%, 17.66%, and 7.36%, respectively. Kernel density analysis was suitable to explore high-risk gathering areas. The peak values of kernel density in the three periods were around 1,110, suggesting that the maximum gathering degree of medium-risk pattern spots basically showed no changes, but the spatial positions of high-risk gathering areas somehow changed. Getis-Ord Gi* analysis was suitable to explore the relationships between hot and cold spots. Counties with high pollution risks were Yongchuan, Shapingba, Dianjiang, Liangping, northwestern Fengdu, and Zhongxian, while counties with low risks were Chengkou, Wuxi, Wushan, Pengshui, and Rongchang. High-value hot spot zones gradually dominated in the northeast of Chongqing, while low-value cold spot zones gradually dominated in the Midwest. Our results provide a scientific base for the development of strategies to prevent and control AGNPS in Chongqing.
Reviving a failed network via microscopic interventions
Authors: Sanhedrai Hillel , Gao Jianxi , Schwartz Moshe , Havlin Shlomo , Barzel Baruch 
Published: December 2020

Abstract
From mass extinction to cell death, complex networked systems often exhibit abrupt dynamic transitions between desirable and undesirable states. Such transitions are often caused by topological perturbations, such as node or link removal, or decreasing link strengths. The problem is that reversing the topological damage, namely retrieving the lost nodes/links or reinforcing the weakened interactions, does not guarantee the spontaneous recovery to the desired functional state. Indeed, many of the relevant systems exhibit a hysteresis phenomenon, remaining in the dysfunctional state, despite reconstructing their damaged topology. To address this challenge, we develop a two-step recovery scheme: first - topological reconstruction to the point where the system can be revived, then dynamic interventions, to reignite the system's lost functionality. Applied to a range of nonlinear network dynamics, we identify a complex system's recoverable phase, a state in which the system can be reignited by a microscopic intervention, i.e. controlling just a single node. Mapping the boundaries of this newly discovered phase, we obtain guidelines for our two-step recovery.
Hyperhomocysteinemia and Acute Coronary Syndrome: A Hospital-Based Observational Study Among Very Young Adults ≤35 Years of Age
Authors: Sun Jiayin , Han Wei , Wu Sijing , Jia Shuo , Yan Zhenxian , Guo Yonghe , Zhao Yingxin , Zhou Yujie , Liu Wei 
Published: December 2020

Abstract
Background: The prevalence of acute coronary syndrome (ACS) continues to increase among young Chinese adults. Homocysteine (HCY) has been suggested as a crucial promoter of atherosclerosis leading to coronary artery disease (CAD). Yet, it remains uncertain whether HCY is associated with the ACS and the severity of coronary artery stenosis in very young adults.Methods: Very young patients (18-35years of age) diagnosed with ACS who underwent coronary angiography (CAG) at Anzhen Hospital between January 2013 and June 2019 were assigned to the ACS group. An equivalent age-matched population without CAD, as confirmed by CAG during the same period, was assigned to the non-CAD group. A serum HCY level>15µmol/L was defined as hyperhomocysteinemia (HHCY). The Gensini score assessed the severity of coronary artery stenosis.Results: A total of 1,103 participants, including 828 ACS patients and 275 non-CAD subjects, were included in this study. Very young ACS patients had higher level of serum HCY and greater prevalence of HHCY compared with non-CAD subjects [for HCY, 16.55 (11.93- 29.68) vs 12.50 (9.71- 17.42), P<0.001; for HHCY prevalence, 62.08% vs 26.18%, P<0.001]. Multivariate logistic regression analysis with the stepwise method indicated that HHCY was an independent predictor associated with the presence of ACS, after adjusting for traditional confounders (OR, 4.393; 95% CI, 3.171-6.087; P<0.001). Moreover, young ACS patients with HHCY had increased prevalence of ST-segment elevation myocardial infarction (STEMI) (P=0.041), multi-vessel disease (P=0.036), and decreased value of left ventricular ejection fraction (LVEF) (P=0.01). Also, the HCY level was signiﬁcantly correlated with Gensini Score in ACS patients (r=0.142, P<0.001).Conclusion: HHCY was significantly associated with the presence of ACS and the severity of coronary artery stenosis in very young patients ≤35 years of age.
Treatment of Depression: Are Psychotropic Drugs Overdosed in Women and in the Elderly? Dosages of Psychotropic Drugs by Sex and Age in Clinical Routine
Authors: Greil Waldemar , de Bardeci Mateo , Bernegger Xueqiong , Cattapan Katja , Stassen Hans , Sieberer Marcel , Grohmann Renate , Toto Sermin 
Published: December 2020

Abstract
Background:Psychotropic drugs show higher concentration-dose ratios in women and in the elderly. Furthermore, women partially exhibit more adverse drug reactions than men. Lower dosages in most psychotropic drugs may be recommended in women and in the elderly. This study describes prescribed dosages of psychotropic drugs in depressive patients across sexes and age groups in clinical routine. Method:In 32’082 inpatients with depressive disorders (data acquired by the European drug safety program AMSP), the influence of sex and age on prescribed dosages are analysed for the 10 most commonly prescribed drugs in our dataset (descending in the frequency of prescription: mirtazapine, venlafaxine, lorazepam, quetiapine, citalopram, escitalopram, olanzapine, duloxetine, zopiclone and sertraline) and additionally zolpidem. Confounding variables for sex differences, such as severity of depression and age distribution are examined. Dose decline in patients over 65 years is calculated. The observed sex and age differences in prescriptions are compared to differences in pharmacokinetic literature.ResultsAmong patients over 65, a statistically significant decrease in dosages for increasing age (between 0.65% and 2.83% every year of age) was observed, except for zopiclone. On the other hand, only slight or no influence of sex in prescribed dosages was found.ConclusionAge definitely influences physicians’ decisions in most drugs, but to a lower extent than pharmacokinetic data suggests. Although lower dosages of psychotropic drugs are appropriate for females according to pharmacokinetic data, they are usually prescribed the same dosage as males. Thus, various psychotropic drugs may be overdosed in women.
Genome-wide identification and analysis of the heat shock transcription factor family in moso bamboo (Phyllostachys edulis)
Authors: Huang Bin , Huang Zhinuo , Ma Ruifang , Chen Jialu , Zhang Zhijun , Yrjälä Kim Yrjälä 
Published: December 2020

Abstract
Heat shock transcription factors (Hsfs) are central elements in the regulatory network that controls plant heat stress response. They are involved in multiple transcriptional regulatory pathways and play important roles in heat stress signaling and responses to a variety of other stresses. We identified 41 members of the Hsf gene family in moso bamboo, which were distributed non-uniformly across its 19 chromosomes. Phylogenetic analysis showed that the moso bamboo Hsf genes could be divided into three major subfamilies; Hsfs from the same subfamily shared relatively conserved gene structures and sequences and encoded similar amino acids. All Hsf genes contained Hsf signature domains. Subcellular localization prediction indicated that about 80% of the Hsf proteins were located in the nucleus, consistent with the results of GO enrichment analysis. A large number of stress response–associated cis-regulatory elements were identified in the Hsf upstream promoter sequences. Synteny analysis indicated that the Hsfs in the moso bamboo genome had greater collinearity with those of rice and maize than with those of Arabidopsis and pepper. Numerous segmental duplicates were found in the moso bamboo Hsf gene family. Transcriptome data indicated that the expression of a number of PeHsfs differed in response to exogenous gibberellin (GA) and naphthalene acetic acid (NAA). A number of Hsf genes were highly expressed in the panicles and in young shoots, suggesting that they may have functions in reproductive growth and the early development of rapidly-growing shoots. This study provides fundamental information on members of the bamboo Hsf gene family and lays a foundation for further study of their biological functions in the regulation of plant responses to adversity.