bluuebunny/crossref_metadata_2025_split huggingface dataset:
LGBTQ+ female protagonists in horror cinema today: The Italian case
Authors: Camilla Lauren De 
Published: March 2020

Abstract
This article examines representations of LGBTQ+ female protagonists in three recent Italian horror films: La terza madre (The Mother of Tears) by , A Pezzi: Undead Men by and The Antithesis by Mirabelli (2017). As homosexuality traditionally falls within the realm of the abject (that which is expelled) in horror films, the genre serves as a medium through which we may assess national and global sensibilities about LGBTQ+ identities. Filmic textual analysis and a consideration of horror and melodrama conventions reveal how these protagonists expose cultural anxieties about non-normative sexual orientations in Italy today. While these films include minority protagonists and offer some resistance to discrimination, they ultimately represent homosexuality as a threat to mainstream Italian culture.
Acute Liver Failure due to Miliary Liver Metastasis
Authors: Lavender Charles A. , Stout Jessica , Chung Hui-Yong , Johnson Michael , Thandassery Ragesh B. 
Published: March 2020

ABSTRACT
Acute liver failure (ALF) is a medical emergency with high mortality. Accurate etiological diagnosis, intensive liver support, and liver transplantation are critical for the management of these patients. Malignant infiltration of the liver uncommonly results in ALF. Diffuse infiltration can be missed by imaging, particularly in early stages, and biopsy is often required to clinch the diagnosis. We report a case of ALF due to diffuse liver metastasis.
Adult-Onset Immunoglobulin A Vasculitis
Authors: Chadwick Matthew , Shamban Leonid , Macksood John 
Published: March 2020

ABSTRACT
Immunoglobulin A vasculitis (IgAV), formerly Henoch–Schönlein purpura vasculitis, is a vasculitis commonly seen in children and only rarely described in adult patients. IgAV can present as arthralgia, rash, discolored urine, acute kidney injury, and gastrointestinal symptoms. We present a case of a 56-year-old man who presented with 1 month of worsening abdominal pain followed by a bilateral lower extremity rash. Laboratory evaluation indicated an acute kidney injury. Computed tomography and colonoscopy revealed terminal ileitis while kidney biopsy confirmed a diagnosis of IgAV.
High-Resolution Esophageal Manometry in Myasthenia Gravis
Authors: Torres-Barrera Gustavo , Herrera-Quiñones Gilberto , Scharrer Susana Isabel , Benavides-Salgado Daniel Eduardo , Maldonado-Garza Hector Jesus , Achem Sami Rene 
Published: March 2020

ABSTRACTMyasthenia gravis (MG) is an autoimmune disease that affects the postsynaptic membrane at the neuromuscular junction. In MG, antibodies bind to acetylcholine receptors inducing muscle weakness. The weakness typically increases with exercise and repetitive muscle use. Improvement of muscular weakness after rest and/or administration of anticholinesterase drugs (edrophonium) are characteristic of MG. We report a patient with unexplained dysphagia, dysphonia, and dysarthria, whose diagnosis was suggested by high-resolution esophageal motility and edrophonium infusion. We highlight the importance of dysphagia as presenting or dominant symptom in MG and review the esophageal motility findings in this rare, but treatable disorder.
Successful Treatment of a Reinfected Liver Graft Because of Receipt of a HCV-Positive Kidney
Authors: Azhari Hassan , Tibbles Lee Anne , Burak Kelly W. , Congly Stephen E. 
Published: March 2020

ABSTRACT
Transplantation of hepatitis C virus (HCV)-positive organs has undergone a paradigm shift because of the advent of direct-acting antivirals. We present the case of a 57-year-old man successfully treated initially with pegylated interferon and ribavirin after HCV recurrence postliver transplantation. He subsequently developed end-stage renal disease and received a genotype 1a HCV-positive kidney transplant. A 12-week course of ledipasvir/sofosbuvir and low-dose ribavirin was initiated and sustained virologic response was achieved. This constitutes the first reported case of a patient successfully treated for HCV a second time after receiving an HCV-positive organ.
Idiopathic Adulthood Ductopenia Causing Cirrhosis
Authors: Douglass Kevin M. , Willner Ira R. , Glenn Douglas J. , Jones Ryan M. 
Published: March 2020

ABSTRACT
Idiopathic adulthood ductopenia (IAD) is a chronic small duct cholestatic biliary disease that is characterized by the loss of interlobular bile ducts. It is diagnosed when there is biochemical evidence of cholestatic liver disease, ductopenia on liver biopsy, and no other identifiable cause of cholestasis. We present a patient with 10 days of progressive abdominal pain, jaundice, and worsening liver function tests who advanced to fulminant liver failure with no apparent underlying cause. He was found to have cirrhosis, with biopsy demonstrative of ductopenia, consistent with idiopathic adulthood ductopenia, which is a rare etiology of cirrhosis but should be considered when the typical workup yields no answer.
Gradient estimates for the fundamental solution of Lévy type operator
Authors: Liu Wei , Song Renming , Xie Longjie 
Published: March 2020

AbstractWe prove a gradient estimate and the Hölder continuity of the gradient for the fundamental solution of a class ofα-stable type operators withα∈ (0, 1), which improve known results in the literature where the conditionα> 1/2 is commonly assumed.
Ready for Combat, Psychophysiological Modifications in a Close-Quarter Combat Intervention After an Experimental Operative High-Intensity Interval Training
Authors: Tornero-Aguilera Jose F. , Fernandez-Elias Valentin E. , Clemente-Suárez Vicente J. 
Published: March 2020

Abstract
Tornero-Aguilera, JF, Fernandez-Elias, VE, and Clemente-Suárez, VJ. Ready for combat, psychophysiological modifications in a close-quarter combat intervention after an experimental operative HIIT. J Strength Cond Res 36(3): 732–737, 2022—This study aimed to analyze the effect of an experimental operative high-intensity interval training (HIIT) program on the psychophysiological response of soldiers in a close-quarter combat (CQC) intervention. The psychophysiological response of 22 professional soldiers in a CQC before and after an experimental 2-week operative HIIT was analyzed. Training intervention produced a significant increase in blood lactate, isometric hand-grip strength, perceived stress, rates of perceived exertion, anxiety response, heart rate, and autonomic sympathetic modulation and a significant decrease in cortical arousal requirements. An experimental operative high-intensity interval training produced an increase on the psychophysiological operativity for CQC scenarios, increasing the sympathetic and physiological response and decreasing the cortical arousal requirement of soldiers.
The Effect of Warm-up Running Technique on Sprint Performance
Authors: Gil Maria H. , Neiva Henrique P. , Alves Ana R. , Sousa António C. , Ferraz Ricardo , Marques Mário C. , Marinho Daniel A. 
Published: March 2020

Abstract
Gil, MH, Neiva, HP, Alves, AR, Sousa, AC, Ferraz, R, Marques, MC, and Marinho, DA. The effect of warm-up running technique on sprint performance. J Strength Cond Res 35(12): 3341–3347, 2021—The purpose of the current study was to analyze the effect of changing the running technique during warm-up on sprint performances, running biomechanics, physiological, and psychophysiological responses. Thirty-one physically active men aged 18–23 years (mean ± SD: 19.35 ± 1.08 years of age; 1.77 ± 0.07 m of height; 71.90 ± 10.37 kg of body mass) volunteered to participate and randomly performed 2 maximal 30-m sprints, 5 minutes after completing a warm-up focused on increased stride length-SL (WUL) or a warm-up focused on increased stride frequency-SF (WUF). The results showed that there were no differences between the 30-m sprint performances and in running biomechanics. However, WUF showed increased performances in the first 15 m of the race (WUF: 2.59 ± 0.11 seconds vs. WUL: 2.63 ± 0.15 seconds; p = 0.03), and WUL resulted in higher performances in the last 15 m (1.94 ± 0.19 seconds vs. 1.88 ± 0.09 seconds; p = 0.05). In the second 30-m time trial, WUF also resulted in faster starting 15 m of the race (2.58 ± 0.12 seconds vs. 2.63 ± 0.16 seconds; p = 0.04). Interestingly, the WUF was the warm-up that revealed more stability in performances and running biomechanics between both trials. These results showed that there were no significant differences between warm-ups comprising exercises focusing in higher SL or higher SF in 30-m sprint biomechanics and performance. Nevertheless, different running strategies were caused by those 2 warm-ups and a more stabilized running pattern, and performance values were found when warm-up focused on higher SF.
Effect of Protective Equipment on Firefighters' External and Internal Workloads During a Simulated Rescue Intervention
Authors: Marcel-Millet Philémon , Ravier Gilles , Groslambert Alain 
Published: March 2020

Abstract
Marcel-Millet, P, Ravier, G, and Groslambert, A. Effect of protective equipment on firefighters' external and internal workloads during a simulated rescue intervention. J Strength Cond Res 36(8): 2291–2297, 2022—Firefighter's protective equipment is one of the main factors increasing psychophysiological demand during rescue intervention. Workload quantification defines the amount of stress placed on an individual. This study aimed to test the relationships and compare different workload methods to discriminate 3 protective equipment conditions based on simulated rescue intervention. The protective equipment was (a) personal protective clothing (PPC); (b) PPC and a self‐contained breathing apparatus (SCBA), including a cylinder, a full‐face piece, and a breathing regulator; and (c) PPC and only the cylinder of the SCBA (SCBAc). Workload was determined using methods based on heart rate (HR), perceived exertion (sRPE), acceleration, and an indirect method based on postexercise HR variability. Differences between conditions were analyzed with repeated-measures analyses of variance. Relationships between workload methods were determined using Pearson's correlations. Statistical significance was set at p < 0.05. The HR-based and sRPE methods showed higher values in the SCBA and SCBAc conditions than the PPC condition (p < 0.0001); only the sRPE method had a higher workload for the SCBA condition than the SCBAc condition (p < 0.0001). Acceleration-based workloads were lower in the SCBA and SCBAc conditions than the PPC condition (p < 0.0001). The indirect method revealed no difference between the 3 conditions. Significant relationships were observed between the HR-based and sRPE methods (r = 0.544–0.738). Inverse significant correlations were observed between the HR-based and sRPE methods and the acceleration workload methods (r = −0.319 to −0.762). Although HR-based and sRPE methods might quantify the workloads, the sRPE method was more sensitive to discriminate between the SCBAc and SCBA conditions.
Synaptic Actions of Amyotrophic Lateral Sclerosis-Associated G85R-SOD1 in the Squid Giant Synapse
Authors: Song Yuyu 
Published: March 2020

AbstractAltered synaptic function is thought to play a role in many neurodegenerative diseases, but little is known about the underlying mechanisms for synaptic dysfunction. The squid giant synapse (SGS) is a classical model for studying synaptic electrophysiology and ultrastructure, as well as molecular mechanisms of neurotransmission. Here, we conduct a multidisciplinary study of synaptic actions of misfolded human G85R-SOD1 causing familial amyotrophic lateral sclerosis (ALS). G85R-SOD1, but not WT-SOD1, inhibited synaptic transmission, altered presynaptic ultrastructure, and reduced both the size of the readily releasable pool (RRP) of synaptic vesicles and mobility from the reserved pool (RP) to the RRP. Unexpectedly, intermittent high-frequency stimulation (iHFS) blocked inhibitory effects of G85R-SOD1 on synaptic transmission, suggesting aberrant Ca2+signaling may underlie G85R-SOD1 toxicity. Ratiometric Ca2+imaging showed significantly increased presynaptic Ca2+induced by G85R-SOD1 that preceded synaptic dysfunction. Chelating Ca2+using EGTA prevented synaptic inhibition by G85R-SOD1, confirming the role of aberrant Ca2+in mediating G85R-SOD1 toxicity. These results extended earlier findings in mammalian motor neurons and advanced our understanding by providing possible molecular mechanisms and therapeutic targets for synaptic dysfunctions in ALS as well as a unique model for further studies.
Overnight/first-morning urine free metanephrines and methoxytyramine for diagnosis of pheochromocytoma and paraganglioma: is this an option?
Authors: Peitzsch Mirko , Kaden Denise , Pamporaki Christina , Langton Katharina , Constantinescu Georgiana , Conrad Catleen , Fliedner Stephanie , Sinnott Richard O , Prejbisz Aleksander , Därr Roland , Lenders Jacques W M , Bursztyn Michael , Eisenhofer Graeme 
Published: March 2020

Objective
Sympathoadrenal activity is decreased during overnight rest. This study assessed whether urinary-free normetanephrine, metanephrine and methoxytyramine in overnight/first-morning urine collections might offer an alternative to measurements in 24-h collections or plasma for diagnosis of pheochromocytoma and paraganglioma (PPGL).

Design and methods
Prospective multicenter cross-sectional diagnostic study involving 706 patients tested for PPGL, in whom tumors were confirmed in 79 and excluded in 627 after follow-up. Another 335 age- and sex-matched volunteers were included for reference purposes. Catecholamines and their free O-methylated metabolites were measured in 24-h collections divided according to waking and sleeping hours and normalized to creatinine. Plasma metabolites from blood sampled after supine rest were measured for comparison.

Results
Urinary outputs of norepinephrine, normetanephrine, epinephrine and metanephrine in the reference population were respectively 50 (48–52)%, 35 (32–37)%, 76 (74–78)% and 15 (12–17)% lower following overnight than daytime collections. Patients in whom PPGLs were excluded showed 28 (26–30)% and 6 (3–9)% day-to-night falls in normetanephrine and metanephrine, while patients with PPGLs showed no significant day-to-night falls in metabolites. Urinary methoxytyramine was consistently unchanged from day to night. According to receiver-operating characteristic curves, diagnostic accuracy of metabolite measurements in overnight/first-morning urine samples did not differ from measurements in 24-h urine collections, but was lower for both than for plasma. Using optimized reference intervals, diagnostic specificity was higher for overnight than daytime collections at similar sensitivities.

Conclusions
Measurements of urinary-free catecholamine metabolites in first-morning/overnight urine collections offer an alternative for diagnosis of PPGL to 24-h collections but remain less accurate than plasma measurements.
Genetic Adaptations of an Island Pit-Viper to a Unique Sedentary Life with Extreme Seasonal Food Availability
Authors: Lu Bin , Wang Xiaoping , Fu Jinzhong , Shi Jingsong , Wu Yayong , Qi Yin 
Published: March 2020

Abstract
The Shedao pit-viper (Gloydius shedaoensis) exhibits an extreme sedentary lifestyle. The island species exclusively feeds on migratory birds during migratory seasons and experiences prolonged hibernation and aestivation period each year (up to eight months). The sedentary strategy reduces energy expenditure, but may trigger a series of adverse effects and the snakes have likely evolved genetic modifications to alleviate these effects. To investigate the genetic adaptations, we sequenced and compared the transcriptomes of the Shedao pit-viper and its closest mainland relative, the black eyebrow pit-viper (G. intermedius). The Shedao pit-viper revealed a low rate of molecular evolution compared to its mainland relative, which is possibly associated with metabolic suppression. Signals of positive selection were detected in two genes related to antithrombin (SERPINC1) and muscle atrophy (AARS). Those genes exert significant functions in thrombosis, inhibiting oxidation and prolonged fasting. Convergent and parallel substitutions of amino acid with two other sedentary vertebrates, which often suggest adaptation, were found in a fatty acid beta-oxidation related gene (ACATA1) and a circadian link gene (KLF10), which regulate lipogenesis, gluconeogenesis, and glycolysis. Furthermore, a circadian clock gene (CRY2) exhibited two amino acid substitutions specific to the Shedao pit-viper and one variant was predicted to affect protein function. Modifications of these genes and their related functions may have contributed to the survival of this island snake species with a sedentary lifestyle and extreme seasonal food availability. Our study demonstrated several important clues for future research on physiological and other phenotypic adaptation.
Natural Seismicity in and around the Rome Trough, Eastern Kentucky, from a Temporary Seismic Network
Authors: Carpenter N. Seth , Holcomb Andrew S. , Woolery Edward W. , Wang Zhenming , Hickman John B. , Roche Steven L. 
Published: March 2020

AbstractThe Rome trough is a northeast-trending graben system extending from eastern Kentucky northeastward across West Virginia and Pennsylvania into southern New York. The oil and gas potential of a formation deep in the trough, the Rogersville shale, which is ∼1  km above Precambrian basement, is being tested in eastern Kentucky. Because induced seismicity can occur from fracking formations in close proximity to basement, a temporary seismic network was deployed along the trend of the Rome trough from June 2015 through May 2019 to characterize natural seismicity.Using empirical noise models and theoretical Brune sources, minimum detectable magnitudes, Mmin, were estimated in the study area. The temporary stations reduced Mmin by an estimated 0.3–0.8 magnitude units in the vicinity of wastewater-injection wells and deep oil and gas wells testing the Rogersville shale. The first 3 yr of seismicity detected and located in the study area has been compiled. Consistent with the long-term seismicity patterns in the Advanced National Seismic System Comprehensive Catalog, very few earthquakes occurred in the crust beneath the Rome trough—only three events were recorded—where the temporary network was most sensitive. None of these events appear to have been associated with Rogersville shale oil and gas test wells. Outside of the trough boundary faults, earthquakes are diffusely distributed in zones extending into southern Ohio to the north, and into the eastern Tennessee seismic zone to the south. The orientations of P axes from the seven first-motion focal mechanisms determined in this study are nearly parallel with both the trend of the Rome trough and with the orientation of maximum horizontal compressive stress in the region. This apparent alignment between the regional stress field and the strikes of faults in the trough at seismogenic depths may explain the relative lack of earthquake activity in the trough compared with the surrounding crust to the north and south.
Observation by Means of An Underground Ring Laser Gyroscope of Love Waves Generated in the Mediterranean Sea: Source Direction and Comparison with Models
Authors: Simonelli Andreino , De Luca Gaetano , Giacomelli Umberto , Terreni Giuseppe , Di Virgilio Angela 
Published: March 2020

AbstractIn fall 2018, we have observed, by means of an underground ring laser gyroscope, the microseismic (MS) activity induced by the Mediterranean Sea in the 2–5 s period range. In the amplitude spectra, a clear peak highly correlated with a collocated seismometer appears during a large storm activity ranging from 24 November to 1 December 2018. The peak of the spectra, both for rotation rate and acceleration, are located at 3.3 s. The peak amplitudes are of 8×10−10  rad/s−1 and 3×10−6  ms−2, respectively, for vertical rotation rate and horizontal acceleration. We perform the source direction estimation by maximizing the correlation of the vertical rotation rate with the transverse acceleration. The local estimation of the direction of the wavefield is then compared with the sea state hindcasts that provide a modeling of the possible MS noise sources.
A Report on Broadband Seismological Experiment in the Jammu and Kashmir Himalaya (JAKSNET)
Authors: Sharma Swati , Mitra Supriyo , Sharma Shubham , Priestley Keith , Wanchoo Sunil K. , Powali Debarchan , Ali Liyaqet 
Published: March 2020

Abstract
A significant Himalayan seismic gap lies between the 2005 Mw 7.6 Kashmir earthquake and the 1905 Mw 7.8 Kangra earthquake, across Jammu and Kashmir, in the northwestern Himalaya. The last great earthquake in this region was the 1555 Mw∼8.0 earthquake, with its meisoseismal zone spanning the entire gap. Recent Global Positioning System geodetic studies have shown that sufficient strain have accumulated in this seismic gap to drive a future Mw∼8.0 earthquake. Seismic hazard assessment in Jammu and Kashmir has been limited by the lack of modern geophysical instrumentation. Very little is known about the crustal structure and earthquake source in this region. Since July 2013, a seismological network (Jammu and Kashmir Seismological Network [JAKSNET]) of 24 broadband three-component seismograph systems have been installed across Jammu and Kashmir, under joint collaborative efforts between Indian Institute of Science Education and Research (IISER) Kolkata, Shri Mata Vaishno Devi University, and University of Cambridge, United Kingdom. Data from this network are archived at the IISER Kolkata seismological observatory and are presently restricted for seismological studies by the participating organizations. The network will be in operation till 2022 and three years after the completion of the experiment the data will be made available following the data sharing policies of the funding agency and the Government of India. In this report, we analyze station noise characteristics and demonstrate that the network performance meets the international standards. We also demonstrate that these stations have recorded high-quality local, regional, and teleseismic data. These dataset are being used for estimation of velocity structure, attenuation characteristics, and earthquake source studies.
L’innovation en élevage : de nouvelles démarches pour de nouveaux enjeux
Authors: MEYNARD J.M. , DOURMAD J.Y. 
Published: March 2020

En guise d’introduction à un numéro spécial de la revue « INRA Productions Animales » sur l’innovation, cet article s’interroge sur la contribution des chercheurs au processus d’innovation. Il montre que les moteurs du changement en agriculture et en élevage appellent à un intense effort de conception innovante, et propose un panorama des démarches qui peuvent être mises en œuvre pour ce faire : conception de novovs pas à pas, conception assistée par modèle vs en atelier de conception, conception au niveau du système d’élevage d’un agriculteur ou au niveau du territoire. Il passe en revue les cadres d’analyse utilisés pour étudier les innovations in situ et anticiper les conditions de leur diffusion : typologies d’adoptants, verrouillage technologique, etc. Il conclut sur l’importance de revisiter la posture des chercheurs vis à vis de l’innovation.
Quintessential Inflation with Dynamical Higgs Generation as an Affine Gravity
Authors: Benisty David , Guendelman Eduardo , Nissimov Emil , Pacheva Svetlana 
Published: March 2020

First, we propose a scale-invariant modified gravity interacting with a neutral scalar inflaton and a Higgs-like SU(2)xU(1) iso-doublet scalar field based on the formalism of non-Riemannian (metric-independent) spacetime volume-elements. This model describes in the physical Einstein frame a quintessential inflationary scenario driven by the &quot;inflaton&quot; together with gravity-inflaton assisted dynamical spontaneous SU(2)xU(1) symmetry
breaking in the post-inflationary universe, whereas SU(2)xU(1) symmetry remains intact in the inflationary epoch. Next, we find the explicit representation of the latter quintessential
inflationary model with a dynamical Higgs effect as an Eddington-type purely affine
gravity.