bluuebunny/crossref_metadata_2025_split huggingface dataset:
Análisis de la actividad laboral de los profesionales sanitarios en formación de la Región de Murcia ante la pandemia por COVID-19
Authors: Sánchez Martínez Domingo Antonio , Madrigal Laguía Pablo , Serrano Porta Santiago , Guardiola Olmos José Ángel , Cañadilla Ferreira Marta 
Published: July 2020

El presente estudio pretende analizar, ante el estado de emergencia sanitaria española (BOE Orden SND/232/2020) decretado por la pandemia del nuevo coronavirus 2019-nCoV, la situación en la que se encuentran los profesionales en formación del Servicio Murciano de Salud (SMS). Para ello se ha realizado un estudio descriptivo llevado a cabo a través de la recogida de datos mediante formulario directo, canalizado a través de la red que conforma el Comité de Empresa, habiéndose obtenido respuesta por parte de al menos un residente de cada uno de los servicios que conforman el SMS y alcanzando un tamaño de muestra que permite la total representatividad del colectivo a estudio. Se trata de un estudio que destaca por la rapidez de reclutamiento de la muestra y la rapidez en su redacción, lo que sirve como una importante herramienta para condicionar futuras políticas y decisiones en el ámbito de los profesionales en formación. La falta de acceso a material de protección por más de la mitad de la población a estudio junto con dificultades para el acceso a información actualizada por parte de la administración, son algunos de los resultados obtenidos tras el análisis de las respuestas. En general, existe una mayoría de residentes que continúan con su labor asistencial, que mantienen el número de guardias mensuales, que piensa que recibe formación oficial adecuada y que se está realizando un plan de contingencia apropiado.
The present study intends to analyze the situation of professionals in training in the Murcian Health Service (SMS) during the state of sanitary emergency in Spain (BOE Order SND/232/2020) due to the pandemic of the new coronavirus 2019-nCoV. To achieve this objective, a descriptive study has been carried out through the collection of data via direct form, channeled through the network that makes up the Comité de Empresa. A response from at least one resident of each of the services that make up the SMS has been obtained. This has allowed a sample size that represents a large amount of the group under study. This is a study that stands out for the rapid acquisition and analysis of the sample, which serves as an important tool to condition future policies and decisions in the field of professionals in training. The lack of access to protection material for more than half of the population under study, as well as difficulties in accessing updated information from the administration are some of the results obtained after analyzing the responses. Overall, there is a majority of residents that continue with their work assistance and which maintain the same number of 24-hour shifts. It is also a main opinion that there is an appropriate health training and contingency plan against COVID-19.
La videoconferencia como herramienta de educación: ¿qué debemos considerar?
Authors: Reinoso-González Eduardo 
Published: July 2020

En la actualidad, la educación se ve enfrentada a una crisis sanitaria a nivel mundial que ha puesto en jaque la continuidad de los procesos de enseñanza, la propagación del virus SARS COV–2 está afectando a la mayor parte de la población debido a su alta capacidad de contagio, lo que ha llevado a tomar como medida principal el confinamiento de las personas y cierre de lugares de alta concurrencia como lo son colegios y universidades. A consecuencia de esto, la internet ha asumido el protagonismo como herramienta digital de tecnología y comunicación más utilizada en el mundo, siendo a su vez, el recurso sostén para la ejecución de videoconferencias, las cuales han tomado un protagonismo único en la formación de estudiantes de nivel superior en modalidad e-learning sincrónico, debido a la contingencia sanitaria. En virtud de ello, ¿qué debemos considerar al momento de implementar las videoconferencias?
Currently, education is faced with a global health crisis that has put the continuity of teaching processes in check, the spread of the SARS COV-2 virus is affecting most of the population due to its high contagion capacity, which has led to taking as a main measure the confinement of people and the closure of places with high attendance such as schools and universities. As a result of this, the internet has assumed prominence as the most used digital technology and communication tool in the world, being in turn, the main resource for the execution of videoconferences, which have taken a unique role in the training of students higher level in synchronous e-learning modality, due to health contingency. By virtue of this, what should we consider when implementing videoconferences?
La littératie en santé chez les personnes présentant des troubles mentaux graves
Authors: Fortin Marie-Pier , Lavoie Mélissa , Dufour Isabelle , Chouinard Maud-Christine 
Published: July 2020

Le Plan d’action 2015-2020 en santé mentale du Québec vise, chez les personnes présentant des troubles mentaux graves, le développement d’une autonomie optimale dans la société et l’utilisation adéquate des services de santé. Néanmoins, à ce jour, un manque de données est rapporté au Québec, sur la capacité des personnes présentant des troubles mentaux à accéder, à comprendre et à utiliser l’information relative à la santé, ce qui correspond au concept de littératie en santé (LS). Une étude descriptive quantitative a été menée pour décrire la LS chez les personnes présentant des troubles mentaux graves et demeurant dans la communauté de Dolbeau-Mistassini, au Saguenay–Lac-Saint-Jean (Québec). Les données ont été collectées à l’aide de trois questionnaires autorapportés, incluant le Questionnaire sur la littératie en santé (QLS). Ce questionnaire permet de décrire la LS à partir de 9 dimensions, afin de soulever les besoins individuels, organisationnels et sociaux en lien avec la LS des personnes ciblées. Les résultats obtenus auprès des participants (n = 30) ont montré que la LS était plus faible dans la dimension « Comprendre l’information relative à la santé ». Les résultats de cette étude mettent en évidence la nécessité d’adapter les interventions éducatives chez cette population. Cette adaptation pourrait permettre à cette population de mieux intégrer le contenu de l’enseignement reçu, tout en privilégiant l’accompagnement d’un proche lors de la rencontre avec un professionnel de la santé.
Les enjeux de littératie dans la communication aux parents du diagnostic de trouble du spectre de l’autisme chez l’enfant
Authors: Valderrama Alena , Courcy Isabelle , Weis-Heitner Lindsay , Forgeot d’Arc Baudouin 
Published: July 2020

Informer les parents dont l’enfant vient de recevoir un diagnostic de trouble du spectre de l’autisme (TSA) est un enjeu majeur. Il est nécessaire de mieux comprendre comment les parents interprètent et s’approprient cette information dans leur vie quotidienne afin de mieux répondre à leurs besoins.
Objectif Mettre en évidence les besoins d’information, le processus de recherche d’information à partir de cadre conceptuel de la littératie en santé (accès, compréhension, interprétation et utilisation) ainsi que les obstacles et les éléments facilitateurs rencontrés.
Méthode Une recherche qualitative auprès de groupes de discussion a été menée avec des parents d’enfants ayant reçu un diagnostic de TSA dans les deux dernières années. Deux des trois groupes étaient formés de parents présentant des facteurs de risque associés à un faible niveau de littératie : monoparentalité, faible scolarité, sans-emploi, immigration récente.
Résultats Un manque généralisé d’information sur l’autisme et des préoccupations quant à la qualité de l’information trouvée sur Internet sont constatés. Tous les parents ont exprimé leur difficulté à comprendre l’information présentée. Le nombre d’obstacles rencontrés par ces derniers dans la recherche d’information s’est révélé être amplifié par des besoins importants de soutien social.
Conclusion Ces résultats soulèvent la nécessité de mieux répondre aux besoins d’information des parents en adaptant les outils proposés en termes d’accès et de compréhension pour la prise de décisions. En plus du soutien informationnel, il demeure crucial d’offrir différentes formes de soutien social, et ce, tout particulièrement aux parents en situation de vulnérabilité. Des propositions pour améliorer la communication sur l’autisme autour du diagnostic sont proposées.
Identification of key genes of human bone marrow stromal cells adipogenesis at an early stage
Authors: Chen Pengyu , Song Mingrui , Wang Yutian , Deng Songyun , Hong Weisheng , Zhang Xianrong , Yu Bin 
Published: July 2020

Background
Bone marrow adipocyte (BMA), closely associated with bone degeneration, shares common progenitors with osteoblastic lineage. However, the intrinsic mechanism of cells fate commitment between BMA and osteogenic lineage remains unclear.

Methods
Gene Expression Omnibus (GEO) dataset GSE107789 publicly available was downloaded and analyzed. Differentially expressed genes (DEGs) were analyzed using GEO2R. Functional and pathway enrichment analyses of Gene Ontology and Kyoto Encyclopedia of Genes and Genomes were conducted by The Database for Annotation, Visualization and Integrated Discovery and Gene set enrichment analysis software. Protein–protein interactions (PPI) network was obtained using STRING database, visualized and clustered by Cytoscape software. Transcriptional levels of key genes were verified by real-time quantitative PCR in vitro in Bone marrow stromal cells (BMSCs) undergoing adipogenic differentiation at day 7 and in vivo in ovariectomized mice model.

Results
A total of 2,869 DEGs, including 1,357 up-regulated and 1,512 down-regulated ones, were screened out from transcriptional profile of human BMSCs undergoing adipogenic induction at day 7 vs. day 0. Functional and pathway enrichment analysis, combined with modules analysis of PPI network, highlighted ACSL1, sphingosine 1-phosphate receptors 3 (S1PR3), ZBTB16 and glypican 3 as key genes up-regulated at the early stage of BMSCs adipogenic differentiation. Furthermore, up-regulated mRNA expression levels of ACSL1, S1PR3 and ZBTB16 were confirmed both in vitro and in vivo.

Conclusion
ACSL1, S1PR3 and ZBTB16 may play crucial roles in early regulation of BMSCs adipogenic differentiation
Ethyl pyruvate inhibits glioblastoma cells migration and invasion through modulation of NF-κB and ERK-mediated EMT
Authors: Huang Qing , Fu Yongming , Zhang Shan , Zhang Youxiang , Chen Simin , Zhang Zuping 
Published: July 2020

Background
Glioblastoma is a grade IV glioma with the highest degree of malignancy and extremely high incidence. Because of the poor therapeutic effect of surgery and radiochemotherapy, glioblastoma has a high recurrence rate and lethality, and is one of the most challenging tumors in the field of oncology. Ethyl pyruvate (EP), a stable lipophilic pyruvic acid derivative, has anti-inflammatory, antioxidant, immunomodulatory and other cellular protective effects. It has been reported that EP has potent anti-tumor effects on many types of tumors, including pancreatic cancer, prostate cancer, liver cancer, gastric cancer. However, whether EP has anti-tumor effect on glioblastoma or not is still unclear.

Methods
Glioblastoma U87 and U251 cells were treated with different concentrations of EP for 24 h or 48 h. CCK8 assay and Colony-Formation assay were performed to test the viability and proliferation. Wound-healing assay and Transwell assay were carried out to measure cell invasion and migration. Western blot was not only used to detect the protein expression of epithelial-mesenchymal transition (EMT)-related molecules, but also to detect the expression and activation levels of NF-κB (p65) and Extracellular Signal Regulated Kinase (ERK).

Results
In glioblastoma U87 and U251 cells treated with EP, the viability, proliferation, migration, invasion abilities were inhibited in a dose-dependent manner. EP inhibited EMT and the activation of NF-κB (p65) and ERK. With NF-κB (p65) and ERK activated, EMT, migration and invasion of U87 and U251 cells were promoted. However the activation of NF-κB (p65) and ERK were decreased, EMT, migration and invasion abilities were inhibited in U87 and U251 cells treated with EP.

Conclusion
EP inhibits glioblastoma cells migration and invasion by blocking NF-κB and ERK-mediated EMT.
Prediction of human fetal–maternal blood concentration ratio of chemicals
Authors: Wang Chia-Chi , Lin Pinpin , Chou Che-Yu , Wang Shan-Shan , Tung Chun-Wei 
Published: July 2020

Background
The measurement of human fetal-maternal blood concentration ratio (logFM) of chemicals is critical for the risk assessment of chemical-induced developmental toxicity. While a few in vitro and ex vivo experimental methods were developed for predicting logFM of chemicals, the obtained experimental results are not able to directly predict in vivo outcomes.

Methods
A total of 55 chemicals with logFM values representing in vivo fetal-maternal blood ratio were divided into training and test datasets. An interpretable linear regression model was developed along with feature selection methods. Cross-validation on training dataset and prediction on independent test dataset were conducted to validate the prediction model.

Results
This study presents the first valid quantitative structure-activity relationship model following the Organisation for Economic Co-operation and Development (OECD) guidelines based on multiple linear regression for predicting in vivo logFM values. The autocorrelation descriptor AATSC1c and information content descriptor ZMIC1 were identified as informative features for predicting logFM. After the adjustment of the applicability domain, the developed model performs well with correlation coefficients of 0.875, 0.850 and 0.847 for model fitting, leave-one-out cross-validation and independent test, respectively. The model is expected to be useful for assessing human transplacental exposure.
Diretivas Antecipadas de Vontade e a concepção do protagonismo do enfermeiro na visão de estudantes de Enfermagem
Authors: Godinho Maria Luzia Machado , Barlem Edison Luiz Devos , Barlem Jamila Geri Tomaschewsk , Rocha Laurelize Pereira , Cogo Silvana Bastos , Dalmolin Graziele De Lima 
Published: July 2020

ObjetiEste artigo tem por objetivo apreender a percepção de estudantes de enfermagem acerca do protagonismo do enfermeiro, em relação às Diretivas Antecipadas de Vontade (DAV). Método: Estudo exploratório, descritivo, com abordagem qualitativa, do qual participaram 15 estudantes de enfermagem de uma universidade pública da Região Sul do Brasil. Os dados foram coletados em outubro de 2017, a partir da metodologia de Grupo Focal, e submetidos à Análise Textual Discursiva. Resultados: os estudantes revelaram a importância de que o enfermeiro conte com conhecimentos técnico-científicos, protagonismo e autonomia no exercício de sua profissão, no que concerne às DAV. O estudo também evidenciou que o grupo investigado considera que ele deve assumir papel de interlocutor entre equipe e família, promovendo autonomia e advocacia do paciente. Considerações Finais: a enfermagem tem um longo caminho a percorrer para consolidar as DAV. A partir de seu uso, o profissional enfermeiro pode garantir que os pacientes tenham suas vontades respeitadas pelo hospital e pelos demais profissionais de saúde.
The Role of Nicotinic Receptors in the Attenuation of Autism‐Related Behaviors in a Murine BTBR T + tf/J Autistic Model
Authors: Mahmood Hafiz M. , Aldhalaan Hesham M. , Alshammari Tahani K. , Alqasem Mashael A. , Alshammari Musaad A. , Albekairi Norah A. , AlSharari Shakir D. 
Published: July 2020

Nicotinic receptors are distributed throughout the central and peripheral nervous system. Postmortem studies have reported that some nicotinic receptor subtypes are altered in the brains of autistic people. Recent studies have demonstrated the importance of nicotinic acetylcholine receptors (nAChRs) in the autistic behavior of BTBR T + tf/J mouse model of autism. This study was undertaken to examine the behavioral effects of targeted nAChRs using pharmacological ligands, including nicotine and mecamylamine in BTBR T + tf/J and C57BL/6J mice in a panel of behavioral tests relating to autism. These behavioral tests included the three‐chamber social interaction, self‐grooming, marble burying, locomotor activity, and rotarod test. We examined the effect of various oral doses of nicotine (50, 100, and 400 mcg/mL; po) over a period of 2 weeks in BTBR T + tf/J mouse model. The results indicated that the chronic administration of nicotine modulated sociability and repetitive behavior in BTBR T + tf/J mice while no effects observed in C57BL/6J mice. Furthermore, the nonselective nAChR antagonist, mecamylamine, reversed nicotine effects on sociability and increased repetitive behaviors in BTBR T + tf/J mice. Overall, the findings indicate that the pharmacological modulation of nicotinic receptors is involved in modulating core behavioral phenotypes in the BTBR T + tf/J mouse model.Lay SummaryThe involvement of brain nicotinic neurotransmission system plays a crucial role in regulating autism‐related behavioral features. In addition, the brain of the autistic‐like mouse model has a low acetylcholine level. Here, we report that nicotine, at certain doses, improved sociability and reduced repetitive behaviors in a mouse model of autism, implicating the potential therapeutic values of a pharmacological intervention targeting nicotinic receptors for autism therapy. Autism Res 2020, 13: 1311–1334. © 2020 International Society for Autism Research, Wiley Periodicals, Inc.
CD30‐positive lymphomatous (nonleukemic) variant of adult T‐cell leukemia/lymphoma, HTLV‐1 associated
Authors: Podberezin Mark , Sohani Aliyah R. 
Published: July 2020

AbstractNonleukemic variant of HTLV‐1‐associated adult T‐cell leukemia lymphoma (ATLL) is a rare variant, and herein, we describe a case with strong and diffuse positivity of neoplastic cells for CD30. Even though ATLL is aggressive entity with poor prognosis, in our case, there was very good clinical response achieved with brentuximab‐containing regimen. Therefore, HTLV‐1‐associated ATLL can be included in the differential diagnostic approach of CD30‐positive lymphoproliferative disorders.
Recycling a Borate Complex for Synthesis of Polycarbonate Polyols: Towards an Environmentally Friendly and Cost‐Effective Process
Authors: Patil Naganath , Bhoopathi Senthil , Chidara Vamshi , Hadjichristidis Nikos , Gnanou Yves , Feng Xiaoshuang 
Published: July 2020

AbstractIn this investigation, a metal‐free process was developed that enables the synthesis of poly(propylene carbonate) (PPC) diols/polyols by copolymerization of CO2 with propylene epoxide (PO) under environmentally friendly and cost‐effective conditions. This process implies the recycling of triethylborane and of ammonium salts that both enter in the composition of the initiators used to copolymerize CO2 and PO. In complement to the above approach, a polymeric support, poly(diallyl dimethylammonium chloride), was synthesized and modified to carry ammonium carboxylate salts along its chain. The prepared polymeric initiator was utilized to copolymerize CO2 with PO under heterogeneous conditions. Not only were the polymerization results similar to the samples obtained under homogeneous conditions, but the polymer substrate could easily be recovered by simple filtration. The integrity of the polycarbonate diols/polyols and the recycling process were followed by 1H and 11B NMR spectroscopy, gel permeation chromatography, and matrix assisted laser desorption ionization time of flight (MALDI‐TOF) MS.
IoT‐based platform for environment data sharing in smart cities
Authors: Rubí Jesús Noel Suárez , de Lira Gondim Paulo Roberto 
Published: July 2020

SummaryThe technological development and dissemination of IoT equipment have led to large volumes of environmental data which, in some cases, are incomplete, follow different formats of representation, and even have different semantic approaches. All such aspects and the heterogeneity of different IoT components (e.g., network interfaces, communication protocols, data structure, and data semantics) have caused interoperability issues which might hamper the effectiveness of support decision systems for smart cities, where the use of big data and machine learning techniques has been considered, in addition to the exploration of smart city data. This article proposes an environment IoT‐based platform for smart cities that grants interoperability from data capture to knowledge extraction and visualization through the use of Semantic Web Technologies and the definition of an ontology for environment indicators. The components of the platform include IoT devices, gateways, cloud, and fog computing, which are used for a better application of big data techniques. A real environment quality monitoring use case was considered for the validation of the platform. Metrics, such as latency and resources consumption, were analyzed for three communication protocols, namely, MQTT, CoAP, and REST. CoAP adapter provided the best results regarding latency, RAM, and CPU consumption.
Asynchronous gateway reallocation communication in heterogeneous 5G networks
Authors: Kodavati Baburao , Ramarakula Madhu 
Published: July 2020

SummaryBackgroundSmart vision of the world is the latest challenge believing that 5G networks could feed all of our internet device needs. The exchange of information (data) needs not to go through backhaul because lots of capabilities will be available close to where it is needed. Presently, the majority of communications are based on single‐mode transmission. Communications will be more responsive and interactive due to 5G technology. The implementation of 5G faces various problems. It is necessary to improve the network capacity by densification, increasing spectrum, and measuring the spectral efficiency. And it also needs to reduce the latency, and it must be energy efficient.PurposeIt is fit for inter‐access service network (ASN) (asynchronous) communications due to the incapability to maintain vertical handoff communications. The need for vertical handovers hinges on various factors that need to be analyzed concurrently with the signal strength in heterogeneous wireless environment.MethodologyThus, it proposed to utilize a vertical handover decision algorithm centered on the priority and speed of the subscriber. Implementation confirms the claim of the proposed method to achieve better channel utilization and maintains the QoS requirements of the mobile users.FindingsTime latency calculation, evaluation of energy utilization between different nodes, and performance analysis packet loss are evaluated.ConclusionBetter efficiency is attained for data transmission among the users that is one mobile node to other with commercial event management and appropriate processing in each node.