bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of health literacy on medico‐social follow‐up visits among French cancer survivors 5 years after diagnosis: The national VICAN survey
Authors: Ousseine Youssoufa M. , Bouhnik Anne‐Déborah , Peretti‐Watel Patrick , Sarradon‐Eck Aline , Memoli Victoria , Bendiane Marc‐Karim , Durand Marie‐Anne , Mancini Julien 
Published: April 2020

AbstractBackgroundLong‐term medico‐social follow‐up of cancer survivors is a challenge because of frequent subsequent troubles. In particular survivors with lower health literacy (HL) have poorer health and might more often use primary care services. However, the impact of HL on cancer survivors’ medico‐social follow‐up visits is not known. Our aim was to study medico‐social follow‐up and its associated determinants with a focus on HL 5 years after diagnosis.MethodsVICAN is a national survey of French adult cancer survivors 5 years after a primary cancer. The Single‐Item Literacy Screener was used to define functional HL in this sample. We also asked patients to report the frequency of follow‐up visits with a general practitioner (GP) and/or social worker (SW) regarding their cancer disease.ResultsThe 4045 participants were 57.4 ± 12.9 years old at diagnosis (range 20‐82) and 1495 (37%) were classified as having inadequate HL. Most cancer survivors (66.7%) were followed up by a GP regarding their cancer while only 14.5% had contact with a SW. After adjustment for sociodemographic, medical, and psychosocial characteristics, medico‐social follow‐ups (GP and SW visits) were more frequent among survivors with low HL. Furthermore, low income, unemployment, impaired mental health, treatment by chemotherapy, and perception of sequelae and fatigue were also associated with more frequent medico‐social follow‐up. Cancer localization association with medico‐social follow‐up was heterogeneous.ConclusionFrench cancer survivors with limited HL, lower socioeconomic status, and more severe cancer were more likely to use GP care and social services. Raising awareness and training GPs and SWs on medico‐social follow‐up for patients with limited HL seem necessary to support these vulnerable survivors.
Silica‐Assisted Fabrication of N‐doped Porous Carbon for Efficient Electrocatalytic Nitrogen Fixation
Authors: Hu Chao , Liang Sucen , Bai Silin , Yang Juan , Zhang Xu , Qiu Jieshan 
Published: April 2020

AbstractHere we demonstrate a silica‐assisted strategy for the synthesis of N‐doped porous carbon nanoparticles from zeolitic imidazolate framework precursors. As a metal‐free electrocatalyst for N2 reduction to NH3 at ambient conditions, such porous carbon shows an improved catalytic performance compared with the counterpart without the assistance of silica, delivering a higher NH3 formation rate of 7.22 μg h−1 mgcat−1 and a Faradic efficiency of 7.42 % in 0.1 M HCl solution. The mesopores involved in the carbon catalyst are supposed to be responsible for the efficient electroreduction of N2.
Meticulous Doxorubicin Release from pH‐Responsive Nanoparticles Entrapped within an Injectable Thermoresponsive Depot
Authors: Yu Huayang , Ingram Nicola , Rowley Jason V. , Green David C. , Thornton Paul D. 
Published: April 2020

AbstractThe dual stimuli‐controlled release of doxorubicin from gel‐embedded nanoparticles is reported. Non‐cytotoxic polymer nanoparticles are formed from poly(ethylene glycol)‐b‐poly(benzyl glutamate) that, uniquely, contain a central ester link. This connection renders the nanoparticles pH‐responsive, enabling extensive doxorubicin release in acidic solutions (pH 6.5), but not in solutions of physiological pH (pH 7.4). Doxorubicin‐loaded nanoparticles were found to be stable for at least 31 days and lethal against the three breast cancer cell lines tested. Furthermore, doxorubicin‐loaded nanoparticles could be incorporated within a thermoresponsive poly(2‐hydroxypropyl methacrylate) gel depot, which forms immediately upon injection of poly(2‐hydroxypropyl methacrylate) in dimethyl sulfoxide solution into aqueous solution. The combination of the poly(2‐hydroxypropyl methacrylate) gel and poly(ethylene glycol)‐b‐poly(benzyl glutamate) nanoparticles yields an injectable doxorubicin delivery system that facilities near‐complete drug release when maintained at elevated temperatures (37 °C) in acidic solution (pH 6.5). In contrast, negligible payload release occurs when the material is stored at room temperature in non‐acidic solution (pH 7.4). The system has great potential as a vehicle for the prolonged, site‐specific release of chemotherapeutics.
Toward Understanding the Enhanced Pseudocapacitive Storage in 3D SnS/MXene Architectures Enabled by Engineered Surface Reactions
Authors: Qin Jinwen , Hao Linlin , Wang Xin , Jiang Yan , Xie Xi , Yang Rui , Cao Minhua 
Published: April 2020

AbstractThe optimization of three‐dimensional (3D) MXene‐based electrodes with desired electrochemical performances is highly demanded. Here, a precursor‐guided strategy is reported for fabricating the 3D SnS/MXene architecture with tiny SnS nanocrystals (≈5 nm in size) covalently decorated on the wrinkled Ti3C2Tx nanosheets through Ti−S bonds (denoted as SnS/Ti3C2Tx‐O). The formation of Ti−S bonds between SnS and Ti3C2Tx was confirmed by extended X‐ray absorption fine structure (EXAFS). Rather than bulky SnS plates decorated on Ti3C2Tx (SnS/Ti3C2Tx‐H) by one‐step hydrothermal sulfidation followed by post annealing, this SnS/Ti3C2Tx‐O presents size‐dependent structural and dynamic properties. The as‐formed 3D hierarchical structure can provide short ion‐diffusion pathways and electron transport distances because of the more accessible surface sites. In addition, benefiting from the tiny SnS nanocrystals that can effectively improve Na+ diffusion and suppress structural variation upon charge/discharge processes, the as‐obtained SnS/Ti3C2Tx‐O can generate pseudocapacitance‐dominated storage behavior enabled by engineered surface reactions. As predicted, this electrode exhibits an enhanced Na storage capacity of 565 mAh g−1 at 0.1 A g−1 after 75 cycles, outperforming SnS/Ti3C2Tx‐H (336 mAh g−1), SnS (212 mAh g−1), and Ti3C2Tx (104 mAh g−1) electrodes.
Shape‐Selective Targeting on RNA Bulges by Peptidomimetic Metallohelices
Authors: Malina Jaroslav , Scott Peter , Brabec Viktor 
Published: April 2020

AbstractRNA bulges represent one of the most common motifs in the RNA secondary structure and serve in a variety of biological functions. Compounds stabilizing RNA bulges are important for probing RNA structure and function and for therapy of some diseases. Here, the ability of a series of enantiomeric pairs of optically pure bimetallic metallohelices with different flexible linkers to target various RNA bulges is investigated. The results show that binding affinities of the metallohelices to bulged RNA differ and strongly depend on the size of the bulge and the base composition of the bulge loop. Notably, the shorter, more compact, and less flexible metallohelices bind to RNA bulges most efficiently and selectively. Interestingly, the ability of the metallohelices to bind to RNA bulges correlates with their previously reported antimicrobial activity, which suggests that the selective recognition of bulged regions in RNA by the metallohelices might also contribute to their biological activity.
Evolution of High‐Valent Nickela‐Electrocatalyzed C−H Activation: From Cross(‐Electrophile)‐Couplings to Electrooxidative C−H Transformations
Authors: Zhang Shou‐Kun , Samanta Ramesh C. , Del Vecchio Antonio , Ackermann Lutz 
Published: April 2020

AbstractC−H activation has emerged as one of the most efficient tools for the formation of carbon–carbon and carbon–heteroatom bonds, avoiding the use of prefunctionalized materials. In spite of tremendous progress in the field, stoichiometric quantities of toxic and/or costly chemical redox reagents, such as silver(I) or copper(II) salts, are largely required for oxidative C−H activations. Recently, electrosynthesis has experienced a remarkable renaissance that enables the use of storable, safe and waste‐free electric current as a redox equivalent. While major recent momentum was gained in electrocatalyzed C−H activations by 4d and 5d metals, user‐friendly and inexpensive nickela‐electrocatalysis has until recently proven elusive for oxidative C−H activations. Herein, the early developments of nickela‐electrocatalyzed reductive cross‐electrophile couplings as well as net‐redox‐neutral cross‐couplings are first introduced. The focus of this Minireview is, however, the recent emergence of nickel‐catalyzed electrooxidative C−H activations until April 2020.
Modulation of Self‐Separating Molecular Catalysts for Highly Efficient Biomass Transformations
Authors: Lian Lifei , Chen Xiang , Yi Xianfeng , Liu Yubing , Chen Wei , Zheng Anmin , Miras Haralampos N. , Song Yu‐Fei 
Published: April 2020

AbstractThe energetically viable fabrication of stable and highly efficient solid acid catalysts is one of the key steps in large‐scale transformation processes of biomass resources. Herein, the covalent modification of the classical Dawson polyoxometalate (POMs) with sulfonic acids (‐SO3H) is reported by grafting sulfonic acid groups on the POM's surface followed by oxidation of (3‐mercaptopropyl)trimethoxysilane. The acidity of TBA6‐P2W17‐SO3H (TBA=tetrabutyl ammonium) has been demonstrated by using 31P NMR spectroscopy, clearly indicating the presence of strong Brønsted acid sites. The presence of TBA counterions renders the solid acid catalyst as a promising candidate for phase transfer catalytic processes. The TBA6‐P2W17‐SO3H shows remarkable activity and selectivity, excellent stability, and great substrate compatibility for the esterification of free fatty acids (FFA) with methanol and conversion into biodiesel at 70 °C with >98 % conversion of oleic acid in 20 min. The excellent catalytic performance can be attributed to the formation of a catalytically active emulsion, which results in a uniform catalytic behavior during the reaction, leading to efficient interaction between the substrate and the active sites of the catalyst. Most importantly, the catalyst can be easily recovered and reused without any loss of its catalytic activity owing to its excellent phase transfer properties. This work offers an efficient and cost‐effective strategy for large‐scale biomass conversion applications.
Nanoscale Organolanthanum Clusters: Nuclearity‐Directing Role of Cyclopentadienyl and Halogenido Ligands
Authors: Buschmann Dennis A. , Dietrich H. Martin , Schneider David , Birkelbach Verena M. , Stuhl Christoph , Törnroos Karl W. , Maichle‐Mössmer Cäcilia , Anwander Reiner 
Published: April 2020

AbstractTetramethylaluminato/halogenido(X) ligand exchange reactions in half‐sandwich complexes [CpRLa(AlMe4)2] are feasible in non‐coordinating solvents and provide access to large coordination clusters of the type [CpRLaX2]x. Incomplete exchange reactions generate the hexalanthanum clusters [CpR6La6X8(AlMe4)4] (CpR=Cp*=C5Me5, X=I; CpR=Cp′=C5H4SiMe3, X=Br, I). Treatment of [Cp*La(AlMe4)2] with two equivalents Me3SiI gave the nonalanthanum cluster [Cp*LaI2]9, while the exhaustive reaction of [Cp′La(AlMe4)2] with the halogenido transfer reagents Me3GeX and Me3SiX (X=I, Br, Cl) produced a series of monocyclopentadienyl rare‐earth‐metal clusters with distinct nuclearity. Depending on the halogenido ion size the homometallic clusters [Cp′LaCl2]10 and [Cp′LaX2]12 (X=Br, I) could be isolated, whereas different crystallization techniques led to the aggregation of clusters of distinct structural motifs, including the desilylated cyclopentadienyl‐bridged cluster [(μ‐Cp)2Cp′8La8I14] and the heteroaluminato derivative [Cp′10La10Br18(AlBr2Me2)2]. The use of the Cp′ ancillary ligand facilitates cluster characterization by means of NMR spectroscopy.
Coordination Dynamics of Zinc Triggers the Rate Determining Proton Transfer in Human Carbonic Anhydrase II
Authors: Paul Tanmoy Kumar , Taraphder Srabani 
Published: April 2020

AbstractWe present, for the first time, how transient changes in the coordination number of zinc ion affects the rate determining step in the enzyme human carbonic anhydrase (HCA) II. The latter involves an intramolecular proton transfer between a zinc‐bound water and a distant histidine residue (His‐64). In the absence of time‐resolved experiments, results from classical and QM‐MM molecular dynamics and transition path sampling simulations are presented. The catalytic zinc ion is found to be present in two possible coordination states; viz. a stable tetra‐coordinated state, T and a less stable penta‐coordinated state, P with tetrahedral and trigonal bipyramidal coordination geometries, respectively. A fast dynamical inter‐conversion occurs between T and P due to reorganization of active site water molecules making the zinc ion more positively charged in state P. When initiated from different coordination environments, the most probable mechanism of proton transfer is found to be deprotonation of the equatorial water molecule from state P and transfer of the excess proton via a short path formed by hydrogen bonded network of active site water molecules. We estimate the rate constant of proton transfer as
from P and
from T. A quantitative match of estimated kP with the experimental value, (
) suggests that dynamics of Zn coordination triggers the rate determining proton transfer step in HCA II.
Assessing the Viability of the Methylsulfinyl Radical‐Ozone Reaction
Authors: Estep Marissa L. , Moore Kevin B. , Schaefer H. F. 
Published: April 2020

AbstractAlthough integral to remote marine atmospheric sulfur chemistry, the reaction between methylsulfinyl radical (CH3SO) and ozone poses challenges to theoretical treatments. The lone theoretical study on this reaction reported an unphysically large barrier of 66 kcal mol−1 for abstraction of an oxygen atom from O3 by CH3SO. Herein, we demonstrate that this result stems from improper use of MP2 with a single‐reference, unrestricted Hartree‐Fock (UHF) wavefunction. We characterized the potential energy surface using density functional theory (DFT), as well as multireference methodologies employing a complete active‐space self‐consistent field (CASSCF) reference. Our DFT PES shows, in contrast to previous work, that the reaction proceeds by forming an addition adduct [CH3S(O3)O] in a deep potential well of 37 kcal mol−1. An O−O bond of this adduct dissociates via a flat, low barrier of 1 kcal mol−1 to give CH3SO2+O2. The multireference computations show that the initial addition of CH3SO+O3 is barrierless. These results provide a more physically intuitive and accurate picture of this reaction than the previous theoretical study. In addition, our results imply that the CH3SO2 formed in this reaction can readily decompose to give SO2 as a major product, in alignment with the literature on CH3SO reactions.
Self‐Supported 3 D Ultrathin Cobalt–Nickel–Boron Nanoflakes as an Efficient Electrocatalyst for the Oxygen Evolution Reaction
Authors: Yuan Hefeng , Wei Shiwei , Tang Bin , Ma Zizai , Li Jinping , Kundu Manab , Wang Xiaoguang 
Published: April 2020

AbstractThe development of highly active and efficient nonprecious‐metal electrocatalysts for the oxygen evolution reaction is important for the design of renewable energy production and storage devices. In this work, highly dense, ultrathin Co–Ni boride nanoflakes supported on a 3 D CoNi skeleton are fabricated in situ by a simple one‐step, high‐temperature, solid‐state boronation process. As a result of the induced high electroactive surface area and low charge transfer resistance, CoNiB‐700 exhibits high catalytic activity at an overpotential of 262 (η10) and 284 mV (η20) to deliver current densities of 10 and 20 mA cm−2, respectively, with a Tafel slope of 58 mV dec−1 in an alkaline medium towards the oxygen evolution reaction. DFT calculations show that the Ni‐regulated Co–B compound has a lower rate‐determining energy barrier for the *OOH intermediate than the mono‐Co–B compound, which facilitates the production of more active catalytic sites for an accelerated surface charge‐transfer process for the oxygen evolution reaction.
An improved third‐order finite difference weighted essentially nonoscillatory scheme for hyperbolic conservation laws
Authors: Li Guodong , Li Xiaogang , Li Pengfen , Cai Dandan 
Published: April 2020

SummaryIn this article, we present an improved third‐order finite difference weighted essentially nonoscillatory (WENO) scheme to promote the order of convergence at critical points for the hyperbolic conservation laws. The improved WENO scheme is an extension of WENO‐ZQ scheme. However, the global smoothness indicator has a little different from WENO‐ZQ scheme. In this follow‐up article, a convex combination of a second‐degree polynomial with two linear polynomials in a traditional WENO fashion is used to compute the numerical flux at cell boundary. Although the same three‐point information is adopted by the improved third‐order WENO scheme, the truncation errors are smaller than some other third‐order WENO schemes in L∞ and L2 norms. Especially, the convergence order is not declined at critical points, where the first and second derivatives vanish but not the third derivative. At last, the behavior of improved scheme is proved on a variety of one‐ and two‐dimensional standard numerical examples. Numerical results demonstrate that the proposed scheme gives better performance in comparison with other third‐order WENO schemes.
A Telephone and Mail Outreach Program Successfully Increases Uptake of Hepatocellular Carcinoma Surveillance
Authors: Aby Elizabeth S. , Winters Adam C. , Lin Jonathan , Bui Aileen , Kawamoto Jenna , Goetz Matthew B. , Bhattacharya Debika , Pisegna Joseph R. , May Folasade P. , Patel Arpan A. , Benhammou Jihane N. 
Published: April 2020

Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death worldwide. Society guidelines recommend surveillance with abdominal ultrasound with or without serum alpha‐fetoprotein every 6 months for adults at increased risk of developing HCC. However, adherence is often suboptimal. We assessed the feasibility of a coordinated telephone outreach program for unscreened patients with cirrhosis within the Veteran’s Affairs (VA) health care system. Using a patient care dashboard of advanced chronic liver disease in the VA Greater Los Angeles Healthcare System, we identified veterans with a diagnosis of cirrhosis, a platelet count ≤ 150,000/uL, and no documented HCC surveillance in the previous 8 months. Eligible veterans received a telephone call from a patient navigator to describe the risks and benefits of HCC surveillance. Orders for an abdominal ultrasound and alpha‐fetoprotein were placed for veterans who agreed to surveillance. Veterans who were not reached by telephone received an informational letter by mail to encourage participation. Of the 129 veterans who met the eligibility criteria, most were male (96.9%). The most common etiology for cirrhosis was hepatitis C (64.3%), and most of the patients had compensated cirrhosis (68.2%). The patient navigators reached 32.5% of patients by phone. Patients in each group were similar across clinical and demographic characteristics. Patients who were called were more likely to undergo surveillance (adjusted odds ratio = 2.56, 95% confidence interval: 1.03‐6.33). Most of the patients (72.1%) completed abdominal imaging when reached by phone. Conclusion: Targeted outreach increased uptake of HCC surveillance among patients with cirrhosis in a large, integrated, VA health care system.
Comparison of different imaging modalities for the quantification of tricuspid valve geometry and regurgitation: a retrospective, single‐center study
Authors: Öztürk Can , Schueler Robert , Weber Marcel , Nickenig Georg , Hammerstingl Christoph 
Published: April 2020

AbstractBackground and AimsTricuspid regurgitation (TR) is a frequent valvular heart disease with relevant adverse impact on patients' prognosis. Adequate TR imaging and evaluation is challenging. In this study, we aimed to compare different imaging modalities (echocardiography and multi‐slice computed tomography) for the assessment of tricuspid valve (TV) function and geometry.MethodsWe retrospectively investigated patients that presented to University Hospital Bonn, Germany, between September 2018 and March 2019, who underwent comprehensive echocardiography and multi‐slice computed tomography (MSCT) to evaluate TR. MSCT was considered the reference approach for dimensional assessment of TV anatomy and echocardiography (transthoracic echocardiography + transesophageal echocardiography) for functional assessment of TV. We used Spearman's Rank order correlation, Bland‐Altman analysis, and intra‐class correlation to compare the different imaging modalities.ResultsForty patients (Mean Age ± SD: 77.5 ± 7.1 years; 35% female) with high grade TR (effective regurgitant orifice area, EROA: 0.49 ± 0.3 cm2, RegVol: 49.5 ± 13.4 mL) were included. There was a statistically significant but moderate correlation between 2D‐TEE and MSCT for anteroposterior (AP) (r = 0.68, 95% confidence interval [CI]: 0.44‐0.93, P = .05; intraclass correlation [ICC]: 0.77, P = .03) and septolateral (SL) diameters (r = 0.71, 95% CI: 0.33‐0.93, P = .03; ICC = 0.76, P = .05). MSCT and 3D‐TEE showed a strong correlation for determination of TV annulus area (r = 0.94, 95% CI: 0.57‐0.98, P = .002; ICC = 0.95, P = .4), perimeter (r = 0.9, 95% CI: 0.6‐0.98, P = .002; ICC = 0.97, P = .3) and diameters (AP‐Diameter: r = 0.73, 95% CI: 0.06‐0.94, P = .03; ICC = 0.83, P = .09; SL‐Diameter: r = 0.86, 95% CI: 0.47‐0.97, P = .02; ICC = 0.95, P = .1). Only 3D‐TEE allowed for direct measurement of planimetric EROA, which exhibited a significant difference from calculated EROA (0.49 ± 0.4 cm2, 0.67 ± 0.17 cm2, P = .05; r = 0.93, 95% CI: 0.5 to 0.99, P = .006). According to Bland‐Altman analysis, we found a relevant agreement between MSCT and 3D‐TEE only for TV area (bias: −1.95, 95% limits of agreement −3.6 to −0.1).ConclusionOnly 3D‐TEE allowed for sufficient simultaneous functional and dimensional assessment of TR in our cohort.
Development in canal lining technology in China
Authors: Ding Kunlun , Gao Lihui 
Published: April 2020

AbstractCanal seepage control is important not only to reduce the canal seepage loss rate, but also to prevent erosion, deposition and collapse of canals and control the surrounding groundwater level, which is taken seriously by the governments. This study reviews the history of canal seepage control in China, introduces the canal lining technologies, concludes the canal lining construction problems and points out the further study fields of seepage control in canals. With the enhancement of environmental protection consciousness, seepage control engineering is confronted with new opportunities and challenges, especially the ecological canals, of which the relative technologies need to be deeply studied.