bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluasi Penggunaan Obat Antihipertensi pada Pasien Pre-Eklampsia Rawat Inap di RSUD Prof. Dr. Margono Soekarjo Purwokerto
Authors: Andriana Dorothea Dwi , Utami Esti Dyah , Sholihat Nia Kurnia 
Published: September 2020

Tujuan penelitian ini adalah untuk mengetahui pola penggunaan dan kesesuaian penggunaan obat antihipertensi pada pasien pre-eklampsia rawat inap RSUD Prof. Dr. Margono Soekarjo Purwokerto. Penelitian dilakukan secara retrospektif dan sampel diambil secara simple random sampling pada pasien rawat inap periode Januari 2015-Juni 2016 yang memenuhi kriteria inklusi. Analisa dilakukan secara deskriptif dan dibandingkan dengan standar Queensland Clinical Guideline tahun 2015 untuk menilai ketepatan indikasi, obat dan dosis serta acuan BNF tahun 2015 untuk menilai ketepatan pasien. Hasil penelitian dari 85 sampel menunjukkan mayoritas pasien pre-eklampsia berusia 21-35 tahun (57,65%) dengan usia kehamilan pada 36-43 minggu (68,24%), dengan diagnosis pre-eklampsia berat (69,41%). Antihipertensi yang banyak digunakan berupa monoterapi nifedipin (64,71%). Persentase kesesuaian antihipertensi menghasilkan 91,76% tepat indikasi; 87,18% tepat obat; 98,72% tepat pasien dan 100% tepat dosis, dengan persentase kerasionalan penggunaan antihipertensi adalah 77,65%.
Distribution and Habitat Karakteristics of Shrimp Juvenile in Segara Anakan Lagoon
Authors: Purnamaningtyas Sri Endah , Tjahjo Didik Wahju Hendro 
Published: September 2020

Shrimp is a wealth of fishery resources are abundant and has a high economic value in Laguna Segara lagoon. So the existence and habitat of life from larvae to adult need attention to maintain the survival of shrimp. Therefore, the purpose of this research is to know the distribution of abundance and characteristics of shrimp juvenile habitat in Segara Anakan lagoon. Sampling is done 3 times (June, August and October 2013), with 9 stations Observation station. The results showed that the abundance of shrimp based on the amount in Segara Anakan lagoon was dominated by Metapenaeus elegans (205-8723 ind./1000 m2), whereas the abundance of M. ensis, F merguensis, P. semisulcatus and P. monodon relatively low had the same habitat , ie waters with high fertility and relatively low salinity, relatively high pH. Found in Motean observation station, Muara Dua, Kleces and Majingklak. Harpiosquilla annandalei (0-330 ind/1000 m2), P. monodon (0-238 ind/1000 m2), and Acetes sp (0.1-5.196 ind/1000 m2) sounded a lot of water habitat that contain BOT and high zooplankton abundance. Thus the shrimp Harpiosquilla annandalei, P. monodon, and Acetes sp are found in Tritih observation stations, and are quite commonly found in Kleces observation stations. Keywords: abundance, habitat preferences, juvenile shrimp, Segara Anakan Lagoon
Seahorse Acoustic Reflection on Active and Passive Moving Condition : A Prelyminary Observation in Watertank
Authors: Apdillah Dony , Jaya Indra , Manik Henry Munandar , Hestirianoto Totok , Febrianto Try 
Published: September 2020

Identification and estimation of seahorse population in the marine environment are difficult to obtain. Nowadays, the observations use visual techniques, biologic and statistics. Bio-statistics approach has some limitations, such as times consuming and low accuracy. An approach was required to provide more accurate information, comprehensive, and based on telemetry (underwater acoustic). Acoustic reflection is an important information to observe underwater objects that can be used for stock assessment and behavioral studies. This research is a preliminary observation and measurement of seahorse Target Strength (TS). The results show that there are differences in TS value of seahorse at the active and passive moving condition. The fluctuations of TS values in active conditions are higher than those in passive conditions. This study has also found that the average TS value of seahorse in active moving conditions is -54.49 dB (± 3 dB). It is greater than the mean TS value in passive moving conditions -59.64 dB (± 3 dB). The approach of immobile fish (the passive moving condition) on the seahorse is better to increase the correlation value between TS to size. The relationship between TS and the size of the seahorse are discussed in the results of this study
The Role of Turmeric Powder Supplementation in Improving Liver Performances to Support Production of Siam Catfish (Pangasianodon hypophthalmus)
Authors: Dewi Cut Dara , Ekastuti Damiana Rita , Sudrajat Agus Oman , Manalu Wasmen 
Published: September 2020

In oviparous animals, the qualities of offspring are determined by the materials deposited in the developing oocytes that are synthesized and produced by the hepatocytes under the control of estrogen. This study was designed to evaluate the effect of turmeric powder supplementation on liver performance to support the reproduction performances of catfish (Pangasianodon hypophthalmus). The study used 60 catfish with average body weight of ± 2 kg. The experimental catfish were assigned into a completely randomized design with 4 treatments and each treatment consisted of 15 replications. The treatment was the dose of turmeric powder supplementation in the commercial feed i.e., 0, 240, 480, and 960 mg/100 g feed. The experimental catfish were fed two times a day in the morning and in the evening as much as 3% of body weight. The results showed that turmeric powder supplementation at a dose of 240 mg/100 g feed could inhibit liver cell destruction in the catfish as was indicated by the increase in body weight, liver weight, and DNA concentrations of liver, as well as the decrease in the liver malondialdehyde, and serum glutamic piruvic transaminase, serum glutamic oxaloacetic transaminase concentrations. Turmeric powder supplementation can be used in oviparous animals and fish to increase liver function and capacity to synthesize vitellogenin to be deposited in the developing follicles during reproduction phase.
Bioremediation of Indigosol Blue 04B Batik Effluent by Indigenous Fungal Isolates, Aspergillus spp.
Authors: Dewi Ratna Stia , Kasiamdari Rina Sri , Martani Erni , Purwestri Yekti Asih 
Published: September 2020

Effluent from the local batik home industry is a serious problem, because the effluent discharge generated is spread in different places. Untreated effluent can cause environmental pollution, such as in groundwater reservoirs,because most is discharged into rivers. The aim of this research was to evaluate the bioremediation potential of indigenous fungi in liquid culture media with Indigosol Blue 04B (IB) batik effluent. The fungi isolates tested were Aspergillus sp. 1, Aspergillus sp. 2 and Aspergillus sp. 3, isolated from dye effluent soil and batik effluent, and compared to white rot fungi (Phanerochaete chrysosporium) as a positive control. The physiochemical properties of IB batik effluent before and after fungal treatment were investigated. All of these parameters before the fungal treatment were above the recommended standard values based on the Governor regulation of Yogyakarta Special Region No. 7/2010. The level of biochemical oxygen demand (BOD), chemical oxygen demand (COD), total dissolved solids (TDS), total suspended solids (TSS), and electrical conductance (EC) was reduce by Aspergillus spp. The highest percentage reduction was achieved by Aspergillus sp. 3, namely 88.34% BOD, 89.11% COD, 75.77% TSS, 85.85% TDS and 71.21% EC, after 3 days of incubation. These results show that the positive control isolate had the lowest value. The study confirms the ability of indigenous fungi isolates in the remediation of IB batik effluent and their potential for future analysis in the treatment of all types of batik effluent.
Pengembangan “Buku Saku Pintar Gizi” Untuk Siswa SMP: Alternatif Media Pembelajaran untuk Meningkatkan Pengetahuan Gizi Olahraga
Authors: Festiawan Rifqi , Arovah Novita Intan 
Published: September 2020

Tujuan penelitian ini untuk menghasilkan produk berupa buku saku yang efektif untuk meningkatkan pengetahuan siswa tentang gizi olahraga dan dapat diterima dengan baik oleh siswa. Metode penelitian yang digunakan merupakan Research and Development (RnD) yang terdiri dari beberapa tahap: 1) identifikasi Potensi dan Masalah, 2) Pengumpulan Bahan, 3) Desain Produk, 4) Pembuatan Produk, 5) Validasi Produk, 6) Ujicoba Terbatas, dan 7) Revisi Produk. Hasil penilaian ahli materi mendapat nilai 85% dengan kategori “sangat baik”, ahli media mendapatkan nilai 88% dengan kategori “sangat baik” dan ahli bahasa mendapatkan nilai 90% dengan kategori “sangat baik”. Penilaian dari siswa mendapat nilai 91% dengan kategori “sangat baik”. Selain itu dari hasil uji efektifitas menunjukkan bahwa buku saku yang dikembangkan efektif untuk meningkatkan pengetahuan gizi siswa Sekolah Menengah Pertama dilihat dari nilai t hitung sebesar 14,41 dan t tabel sebesar 2,042 sehingga t hitung > t tabel. Dari hasil tersebut, dapat disimpulkan bahwa dari penilaian ahli dan siswa, buku saku yang dikembangkan layak digunakan sebagai salah satu alternatif media pembelajaran siswa di sekolah dengan presentase total 88,5% dan buku saku yang dikembangkan terbukti efektif untuk meningkatkan pengetahuan siswa.
A Comparison Between Two Shape Parameters Estimators for (Burr-XII) Distribution
Authors: Kareem Shurooq Ahmed 
Published: September 2020

This paper deals with defining Burr-XII, and how to obtain its p.d.f., and CDF, since this distribution is one of failure distribution which is compound distribution from two failure models which are Gamma model and weibull model. Some equipment may have many important parts and the probability distributions representing which may be of different types, so found that Burr by its different compound formulas is the best model to be studied, and estimated its parameter to compute the mean time to failure rate. Here Burr-XII rather than other models is consider because it is used to model a wide variety of phenomena including crop prices, household income, option market price distributions, risk and travel time. It has two shape-parameters (α, r) and one scale parameter (λ) which is considered known. So, this paper defines the p.d.f. and CDF and derives its Moments formula about origin, and also derive the Moments estimators of two shapes parameters (α, r) in addition to maximum likelihood estimators as well as percentile estimators, the scale parameter (λ) is not estimated (as it is considered known). The comparison between three methods is done through simulation procedure taking different sample size (n=30, 60, 90) and different sets of initial values for (α, r, λ).It is observed that the moment estimators are the best estimator with percentage (46%) ,(42%) respectively compared with other estimators.
Modification of Irisin Level in Overweight/Obese Women during Pregnancy and Its Association with Some Metabolic Risk Factors
Authors: Hamza Mohammad Ahmad , Al Tamer Yassar Yahya , Al habib Omar Abdulmajeed 
Published: September 2020

Irisin is a novel myokine and adipokine, its role during pregnancy and its association with some metabolic risk factors especially pre-pregnancy body mass index (pre-BMI) need more evaluation. The aim of the study is to find whether the pre-BMI could predict irisin levels during normal pregnancy and to clarify associations of irisin with some pathological parameters.
Irisin levels were estimated by ELISA in sera of 59 normal pregnant women who enrolled from December 2016 to May 2017 at Maternity Hospital, Zakho city, Kurdistan region (Iraq). Thirty-two normal-weight pregnant (pre-BMI≤24.9 kg/m2, Age=24.03 mean±3.7standard deviation) and 27 overweight/obese-pregnant (pre-BMI>25 kg/m2, Age=27.6 mean±3.9 standard deviation) were accounted for each trimester as10: 8 in first trimester, 10:10 in second trimester and12:9 in third trimester respectively. Twenty-two healthy married non-pregnant women of reproductive age served as controls, accounted as 10 normal-weight women (BMI ≤24.9 kg/m2) and 12 overweight/obese women (BMI>25 kg/m2).
In pregnant women as a whole, irisin level significantly increased compared to control (p=0.003), and correlated with the pre-BMI, FBS, TP and HOMA2-IR. Pre-BMI and TP predicted irisin levels in a whole study population (p=0.011 and 0.014 respectively). In Overweight/Obese-pregnant, irisin increased significantly by 55.3% in first trimester compared with Overweight/Obese women control, then decreased progressively toward the end of gestation, correlated with TP, Albumin, FBS, HOMA2-IR and negatively correlated with gestational weight gained. TP and FBS independently predicted irisin level in Overweight/Obese-pregnant group.
Conclusion: Circulating irisin levels are influenced by pre-BMI, and both of TP and FBS predict irisin levels in overweight/obese pregnant. Irisin level should be a radical factor in future studies for pathological conditions linked to hypoproteinemias such as edema and hepatic disease.
Acute effect of green tea catechins on uric acid metabolism after alcohol ingestion in Japanese men
Authors: Kawakami Yuka , Yasuda Arisa , Hayashi Motoki , Akiyama Misuzu , Asai Toshihiko , Hosaka Toshio , Arai Hidekazu 
Published: September 2020

Abstract
Alcohol consumption is associated with hyperuricemia and gout. Previous studies have indicated a role for green tea catechins in uric acid (UA) metabolism. This study aimed to elucidate the acute effect of green tea catechins in terms of enhancing urinary excretion of UA and xanthine/hypoxanthine (Xa/HX; UA precursors) after alcohol ingestion. In a randomized crossover study, ten healthy Japanese subjects consumed test meals, including a Japanese distilled spirit (Shōchū) with water (SW) or Shōchū with catechin-rich green tea (SC), each containing 20 g of alcohol. The SC contained 617 mg of catechin in total. Serum and urine UA and Xa/HX concentrations were measured. Blood samples were collected after 2.5 h, and urine samples were collected between 0 and 5 h after consuming the test meal. Urine UA and Xa/HX excretions were significantly higher in the SC group than in the SW group. UA clearance and fractional UA excretion tended to increase more in the SC group than in the SW group. No significant differences in serum UA and Xa/Hx concentrations were observed between two groups. It was concluded that green tea catechins can enhance the excretion of UA and Xa/HX, even though alcohol is ingested.
ddRAD-seq Reveals Cryptic Phylogeographic Structure and Adaptive Population Differentiation of&nbsp;Hyporhamphus Intermedius&nbsp;in&nbsp;Heterogeneous&nbsp;Environments from China Mainland
Authors: Wang Gongpei , Lai Han , Bi Sheng , Guo Dingli , Zhao Xiaopin , Chen Xiaoli , Liu Shuang , Liu Xuange , Su Yuqin , Yi Huadong , Li Guifeng 
Published: September 2020

Abstract
BackgroundSpecies differentiation and local adaptation in heterogeneous environments have been getting a large focus but poor knowledge of the mechanism. With widespread in coastal areas and the hyperdiverse freshwater systems in China, Hyporhamphus intermedius is an excellent material for phylogeography and local adaptation research. Here, 156 individuals were sampled in 8 sites from heterogeneous aquatic habitats to comprehend environmental and genetic contributions to phenotypic divergence. Results32,744 SNPs among populations and obvious population differentiation was found by ddRAD-seq among groups from the different watersheds. Population genetic structure was partly geographic, successfully classifying all individuals into three genetic subgroups corresponding to the North, the South and the Plateau Lakes with more migrations within region. Due to the transplant event, the strikingly increasing divergence in a short time indicated the tendency of local differentiation for introduced populations in the Plateau Lakes. Dorsal and anal traits varied widely between the Southern and others, which highlighted previously unrecognized lineages. Furthermore, we inferred the whole population is in response to balancing selection from neutrality test with positive value (Tajima's D=2.773), and demographic history underlay two main split events from the northern ancestral population. Subgroup ranges appear to counterparts to geographic regions with heterogeneous hydrological factors, indicating these features are likely important drivers of diversification.ConclusionsAccordingly, our results revealed that genetic polymorphism and divergence of Hyporhamphus intermedius in heterogeneous environments might be ascribed to a consequence of balancing selection, gene flow at microscales, and the impact of abiotic factors, verifying potentially that genetic differences among populations are the result of both genetic canalization and plastic responses to environmental heterogeneity.
With Antibiotic Cement Versus Without Antibiotic Cement in the Treatment of Tibial Osteomyelitis After Radical Debridement: A Randomized Controlled Trial
Authors: Yang Jinxing , Han Yun , Liu Lijun , Chen Hongxian , Huang Junfeng , Xu Xu 
Published: September 2020

Abstract
Background: In most of the cases, antibiotic cement is recommended to fill the dead space after debridement of osteomyelitis. As to local Cierny-Mader Type IV tibial osteomyelitis, radical debridement of the infected bone can be achieved, after that, is it still necessary to apply antibiotic cement to the dead space? This study was aimed to answer the question.Methods: From January 2010 to January 2015, 64 patients with local Cierny-Mader Type IV tibial osteomyelitis were included and randomly divided into two groups. Patients in the cement group were treated with antibiotic-impregnated bone cement after radical debridement of the infected bone (cement group), while the other patients in the without cement group were not applied any cement after the same debridement (without cement group). Both groups were operated by the same surgical team and applied Ilizarov bone transport to fill the bone defect.Result: All patients in both groups achieved successful healing with bone union at both corticotomy and tibial docking sites. At the end of follow-up，there was one case of infection recurrence in each groups. There were no differences in demographics and clinical variables between the two groups. There was also no difference either in terms of bone results or functional results between the two groups (c 2=0.006 for bone results and c 2=1.339 for functional results). But there was significant difference in terms of total hospitalization expenses between the two groups (P＜0.001, the cement group was much higher than the without cement group).Conclusion: When radical debridement is achieved in dealing with local Cierny-Mader Type IV tibial osteomyelitis, it is no need to apply antibiotics cement in the dead space, but it needs more cases to increase the convincingness.Trial registration: ChiCTR-TNRC-10002837，retrospectively registered.
Analysis of Histology and Long Noncoding RNAs Involved in the Rabbit Hair Follicle Density using RNA Sequencing
Authors: Ding Haisheng , Zhao Huiling , Zhao Xiaowei , Qi Yunxia , Wang Xiaofei , Huang Dongwei 
Published: September 2020

Abstract
Background: Hair follicle density influences wool fibre production, which is one of the most important traits of the Wan strain Angora rabbit. However, molecular mechanisms regulating hair follicle density have remained elusive. Results: In this study, hair follicle density at different body sites of Wan strain Angora rabbits with high and low wool production (HWP and LWP) was investigated by histological analysis. Haematoxylin-eosin staining showed a higher hair follicle density in the skin of the HWP rabbits. The long noncoding RNA (lncRNA) profile was investigated by RNA sequencing, and 50 and 38 differentially expressed (DE) lncRNAs and genes, respectively, were screened between the HWP and LWP groups. A gene ontology analysis revealed that phospholipid, lipid metabolic, apoptotic, lipid biosynthetic, and lipid and fatty acid transport processes were significantly enriched. Potential functional lncRNAs that regulate lipid metabolism, amino acid synthesis, as well as the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) and hedgehog signalling pathways, were identified. Consequently, five lncRNAs (LNC_002171, LNC_000797, LNC_005567, LNC_013595, and LNC_020367) were considered to be potential regulators of hair follicle density and development. Three DE lncRNAs and genes were validated by quantitative real-time polymerase chain reaction (q-PCR). Conclusions: LncRNA profiles provide information on lncRNA expression to improve the understanding of molecular mechanisms involved in the regulation of hair follicle density.
Phosphoproteome Reveals the Lactation Mechanism in Caprine Mammary Gland Tissues in Peak and Late Lactation Stages
Authors: Zhu Chao , Yin Hao , Duan Quyu , Li Fu , Jiang Yue , Zhu Junru , He Yonglong , Li Wenfei , Wang Zhanhang , An Xiaopeng 
Published: September 2020

Abstract
Background: Protein phosphorylation plays an important role in lactation. Differentially modified modification sites between peak lactation (PL, 90 days postpartum) and late lactation (LL, 280 days postpartum) were investigated using an integrated approach, namely, liquid chromatography with tandem mass spectrometry (LC-MS/MS) and tandem mass tag (TMT) labelling, to understand the molecular biological mechanisms in goat breast tissues.Results: A total of 1,938 (1,111 up-regulated, 827 down-regulated) differentially modified modification sites of 1,172 proteins were identified (P values < 0.05 and fold change of phosphorylation ratios > 1.5). In addition, the Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis showed that ribosome (chx03010), RNA transport (chx03013), protein export (chx03060), calcium signalling pathway (chx04020), oxytocin signalling pathway (chx04921), RNA degradation (chx03018) and MAPK signalling pathway (chx04010) were enriched in relation to energy metabolism and protein translation. The results of western blot showed phosphorylation levels of ACACA, EIF4EBP1 and IRS1 increased and JUN decreased in PL compared with LL. The result was consistent with phosphoproteome. Conclusions: Overall, these data indicate that protein phosphorylation is closely related to lactation and differentially modified modification sites might have potential research value in the regulation of goat lactation.