bluuebunny/crossref_metadata_2025_split huggingface dataset:
Progressive structural change in the Central American integration process
Authors: Martínez–Piva Jorge Mario 
Published: June 2020

The intellectual history of ECLAC has been one of “continuity with changes”. These changes allowed adjusting policy proposals and action plans to the ever–changing international environment.
ECLAC has proposed to the Central American region mainly three development models in the last 70 years: the first one, to overcome the agro–export phase based on primary products (“outward development”) ECLAC proposed a process of industrialization and urbanization (“inward development” or “industrialization by import substitution”; the second one, was the integration with the global economy along with strengthening regional integration (“open regionalism”); and the third, more recently, a productive transformation with emphasis in equality (“progressive structural change”).
The objective of this paper is to identify a set of economic policies that could operationalize recent ECLAC’s development proposal called “progressive structural change”. The progressive structural change groups strong ideas based on the need to renew productive policy, promote sustainable development and place equality at the center of public policy actions.
Conjugation of new DNA vaccine with polyethylenimine induces cellular immune response and tumor regression in neuroblastoma mouse model
Authors: Stegantseva M.V. , Shinkevich V.A. , Tumar E.M. , Meleshko A.N. 
Published: June 2020

Summary. Aim: To estimate immunogenicity and antitumor effect of new DNA vaccine against neuroblastoma using tyrosine hydroxylase as an antigen and linear polyethylenimine (PEI) 20 kDa as a synthetic DNA carrier in syngeneic mouse tumor model. Materials and Methods: DNA vaccine was made by cloning the tyrosine hydroxylase minigene fused to the potato virus X coat protein gene into the expression vector. The A/J mice were vaccinated by three intramuscular injections. For immunogenicity study, immune response was estimated by target cells cytotoxicity assay, interferon-gamma production in enzyme-linked immunospot assay and antigen-specific antibodies in 14 days after the final vaccination. Antitumor effect was assessed by measurement of tumor volume and event-free survival rate in mice with engrafted NB41A3 murine neuroblastoma cells following three intramuscular injections of the vaccine: 7 days before, 5 and 10 days after tumor engraftment. The immune response was also assessed on the 30th day after tumor engraftment. Results: The immunogenicity and antitumor effect of the vaccine in the form of aqueous solution of DNA and DNA-PEI conjugate were compared. Splenocytes cytotoxicity was the highest in the group of DNA-PEI vaccines (37.3 ± 6.9% lysis of target cells) compared with the unconjugated DNA vaccine (26.2 ± 4.0%) and placebo control (21.9 ± 3.7%). The production of interferon-gamma in the enzyme-linked immunospot assay was about ten times higher in the DNA-PEI group than in the other groups. The vaccine slowed or prevented the growth of the tumor. Mice vaccinated with the DNA-PEI vaccine had significantly better survival compared to control group (p < 0.0003). Conclusions: DNA vaccine against tyrosine hydroxylase, administered as a DNA-PEI 20 kDa conjugate, slows down the growth of neuroblastoma cells engrafted to mice.
NANOG as prognostic factor of prostate cancer course
Authors: Zadvornyi T.V. , Lukianova N.Yu. , Borikun T.V. , Vitruk Yu.V. , Stakhovsky E.O. , Chekhun V.F. 
Published: June 2020

Summary. The variability of the clinical course of prostate cancer (PC) indicates the need to find factors that could predict the aggressive potential of neoplasms accounting the biological characteristics of tumor cells. In this context, the role of NANOG, a transcription factor involved in maintaining pluripotency and one of the markers of cancer stem cells (CSCs), is being actively studied today. Aim: To investigate the level of NANOG mRNA in tumor tissue of patients with PC and to analyze the possibility of its use as a marker of the disease course. Materials and Methods: The study involved 85 patients with PC of stages II–IV. Morphological and immunohistochemical studies were performed on serial paraffin sections of resected PC using monoclonal antibodies to Ki-67 and androgen receptor. NANOG and miR-214 mRNA expression in tumor cells was analyzed by real-time reverse transcription polymerase chain reaction. The identification of CSCs was performed by double-labeled immunohistochemical method using primary antibodies to CD24 and CD44. Results: We have revealed notable variability of NANOG mRNA levels in tumor tissue of patients with PC (mean 4.18 ± 0.65 a.u. with individual deviations from 0.11 ± 0.03 a.u. to 15.24 ± 0.36 a.u.). According to NANOG mRNA levels, two groups of the PC patients were delineated: group 1 and group 2, with the average NANOG mRNA levels of 2.12 ± 0.16 a.u., and 8.68 ± 1.24 a.u., respectively. The NANOG mRNA levels in tumor tissue of PC patients of groups 1 and 2 correlated with preoperative serum prostate-specific antigen level (r = 0.58; p < 0.05 and r = 0.64; p < 0.05, respectively), tumor volume (r = 0.42; p < 0.05 and r = 0.72; p < 0.05, respectively), regional lymph node metastases (r = 0.70; p < 0.05 and r = 0.75; p < 0.05, respectively). High NANOG mRNA levels in tumor cells were associated with such molecular and biological features of PC as androgen receptor expression (r = 0.52; p < 0.05), high proliferative activity (r = 0.60; p < 0.05) and the presence of CSC markers (r = 0.75; p < 0.05). Conclusions: The findings indicate that NANOG is involved in the formation of the PC malignancy and should be further studied as a potential marker for the prediction of the disease course.
Hutsul horse breed is an aboriginal breed of the Ukrainian Carpathians
Authors: Starodub L. F. , Stefurak Y. P. , Stefurak I. V. , Zelenchuk I. M. , Zelenchuk Y. I. , Wojcicki R. V. 
Published: June 2020

Hutsul horses are the oldest Ukrainian breed and belong to the local and endangered breeds of farm animals in Ukraine. The formation and preservation of the Hutsul horse breed took place in Ukrainian lands. Proof of this are built: the state factory stable in the village. Drohobych in the Lviv region in 1822, a horse-breeding station for Hutsul horses in the Luchina meadow in Southern Bukovina (1877), in the Galician Hutsul region two stables of Hutsul cucumbers: in Kosovo (1891) and in the village of Zhabye (1895). State Herd of Cucumbers in Sudova Vyshna (1907) in Lviv Region. Of the 6 genealogical lines of prominent Hutsul stallions, 3 ogres were born in the Ukrainian lands – Goral, Gurul and Polyan. Measures for the conservation and development of Hutsul horses are held in the Hutsul and Verkhovyna National Nature Parks in international cooperation within the framework of the Poland-Belarus-Ukraine cross-border cooperation program. Hutsulshchyna National Nature Park in 2015 took part in the project “Creation of the Polish-Ukrainian Center for Breeding and Promotion of Hutsul Breed Horses”, and Verkhovynsky National Nature Park in 2020 takes part in the international Ukrainian-Polish project “Knowledge of Nature and Wealth Carpathians with a Hutsul horse”. According to the State Breeding Register 2011–2017, in Ukraine there is an annual reduction in the number of breeding farms, the total and breeding stock of Hutsul horses. Today, only 2 farms (NGO “Plemkonecentr” and FG “Polonynske farm”) for breeding Hutsul horses have the status of breeders. According to calculations, in accordance with the FAO recommendations, these animals are at critical risk status, and according to the assessment system of the European Livestock Association, Hutsul horse breed is at high risk of losing the gene pool of the breed. To preserve the Hutsul horse breed, the joint cooperation of owners (breeding and private farms) of purebred and the most typical herd of Hutsul horses, scientists and specialists is necessary.
OBRAS PÚBLICAS Y MODERNIDAD EN QUITO
Authors: DelPino-Martínez Inés 
Published: June 2020

El presente artículo expone el proceso de modernización de Quito y la transformación de la ciudad, mediante iniciativas del Estado y la empresa privada, entre 1906 y 1960. Una de las acciones fue la ejecución de obras públicas que dan cuenta del interés de los gobiernos por implantar infraestructuras urbanas que preparan a la ciudad al cambio de época. Este proceso fue posible por la aplicación de políticas públicas de salubridad y la provisión de equipamiento urbano como electricidad, agua potable y alcantarillado, además de telecomunicaciones y arquitectura pública moderna, en altura y construida en hormigón armado. Estos fueron algunos recursos que viabilizaron el discurso de la modernidad y el de la arquitectura moderna. En la práctica, representan otra manera de entender la salud, la higiene personal, el confort, la movilidad; es decir, ser moderno. El artículo fue elaborado, sobre todo, a partir de notas de prensa del periódico El Comercio, medio de comunicación que fue un gran aliado del cambio hacia la modernidad.Palabras clave: Periódico El Comercio, obras públicas, Quito, ciudad moderna, modernidad, siglo XX.
AbstractThis article presents the modernization process of Quito and the transformation of the city through initiatives of the State and private companies, between 1906 and 1965. One of the activities was the execution of public works that show the interest of governments to implement urban infrastructures that prepare the city the conditions to stablish modern architecture. This process was possible due to the submission of public health policies and the provision of urban equipment: electricity, drinking water, sewerage, followed by telecommunications and modern public architecture built in reinforced concrete. These were some resources that made the discourse of modernity and that of modern architecture viable. In practice, they represent another way of understanding health, personal hygiene, comfort, mobility, that is, being modern. The article was elaborated mainly from press releases by "El Comercio" newspaper, a means of communication that was the great ally of the change towards modernity.Keywords: “El Comercio” newspaper, public works, Quito, modern city, modernity, Twentieth century.
Regrassing trends and drivers in the New Zealand dairy industry
Authors: Dodd Michael B , Chapman David F , Ogle Graeme 
Published: June 2020

Pasture renewal is an important strategy for farmers to improve the yield of home-grown forage. This paper quantifies long-term national and regional trends in regrassing within the dairy sector and links these patterns to suggested major drivers, using simple regression analysis. Dairy farm financial data relevant to regrassing expenditure were sourced from annual dairy sector economic reports and DairyBase, while regional potential evapotranspiration deficit data were sourced from climate records and cropping data from a recent MPI report. Real and relative expenditure on regrassing has increased over this period, and appears to be positively associated with both cropping activity and drought severity, particularly in some North Island regions. The emergent picture is one of a complex of interacting drivers (climate, production, prices, forage products, soils and time) which fuel a vicious cycle of poor persistence and resowing. This situation draws attention to the need for solutions to protect regrassing investments.
The story of Tara Hills high-country research
Authors: Allan Bruce E , Chapman Hazel M , Keoghan J M 
Published: June 2020

The 3340 ha Tara Hills high-country station near Omarama was a Government owned research facilitybetween 1948 and 2005. Here we present the story of the rise and fall of Tara Hills; turned from a depletedwasteland into the vibrant research centre of the 1980s, it was eventually sold to commercial interests in theearly 2000s. By the early 1980s, Tara Hills had 14 permanent staff and was internationally recognised as amodel for dryland farm development, experimentation and demonstration. However, subsequent changes inemphasis for New Zealand farming resulted in a decline in dryland research and to the inevitable sale of thishigh-country station. We summarise the broad range of research and its outcomes associated with Tara Hills,spanning soils, pasture species, their establishment and production, irrigation, grazing management,animal breeds, animal production and genetics, and farm systems. The changing face of New Zealand’sagricultural research and extension is an integral part of this story.
Pengembangan Aplikasi Mobile Health Berbasis Android untuk Monitoring dan Evaluasi Stunting
Authors: Hendryani Atika , Susana Ernia 
Published: June 2020

In 2018 Indonesia still ranked fifth as the country with the highest number of stunting in the world. A better level of a mother’s knowledge can decrease about 4% to 5% in the possibility of stunting in children. Efforts to increase maternal knowledge about the importance of preventing stunting in the first thousand days of life are not only the responsibility of the government, especially the Ministry of Health. The mass media are also responsible for providing knowledge to mothers. One of the most widely used media in accessing news and information is through mobile devices such as mobile phones. From this background the problem of this research can be formulated is how to build an Android-based mobile health application for monitoring and preventing stunting. The purpose of this research is to build an Android-based mobile health for stunting monitoring and prevention. The research method is Research and Development consists of two stages, the Research Phase using qualitative methods and the Development Phase using FAST system development methods. The research was conducted at the Poltekkes of the Ministry of Health Jakarta II, Department of Electromedical Engineering from January to December 2019. The results of the study are android mobile health applications for monitoring and evaluating stunting. From the result of system testing, the mobile health application for monitoring and evaluating stunting could work well.
PENGARUH DER DAN RISIKO SISTEMATIS TERHADAP RETURN SAHAM PERUSAHAAN FARMASI YANG TERDAFTAR DI BEI
Authors: Mufid Muhammad Nur 
Published: June 2020

Abstrak Riset ini merupakan penelitian empiris terhadap factor yang mempengaruhi return saham. Objek penelitian ini adalah perusahaan farmasi yang terdaftar di Bursa Efek Indonesia (BEI) dengan periode laporan keuangan tahun 2014-20017. Return saham dihitung dari persentase perubahan harga saham penutupan setiap akhir tahun. Faktor yang diduga mempengaruhi return saham pada penelitian ini adalah rasio hutang (debt to equity ratio) dan tingkat risiko yang diukur dengan beta saham berdasarkan teori capital assest pricing model (CAPM). Teknik pengambilan sampel yang digunakan adalah teknik purposive sampling dimana jumlah sampel yang diperoleh dalam penelitian ini adalah 8 sampel. Data yang digunakan dalam penelitian ini adalah data sekunder. Metode pengujian yang digunakan dalam penelitian ini adalah metode analisis regresi berganda dengan program SPSS dan uji asumsi klasik. Hasil penelitian menunjukkan, bahwa rasio hutang (DER) tidak memberikan pengaruh terhadap return saham , sedangkan risiko sistematis (BETA) memberikan pengaruh signifikan terhadap return saham.Kata kunci: return saham, debt to equity ratio, risiko sistematis Abstract This research is an empirical study of the factors that influence stock returns. The object of this research is companies listed on the Indonesia Stock Exchange (IDX) with the financial reporting period of 2014-20017. Returns shares of high-price securities at the end of each year. The factors that influence returns are the debt to equity ratio and the level that uses the capital capital price model (CAPM). The sampling technique used was purposive sampling technique where the number of samples obtained in this study were 8 samples. The data used in this research is secondary data. The method used in this study is the method of multiple regression analysis with the SPSS program and the classic assumption test. The results showed that the debt ratio (DER) had no effect on stock returns, while systematic risk (BETA) had a significant effect on stock returns. Keywords: stock returns, debt to equity ratio, systematic risk
Triangulação Metodológica:
Authors: Bueno Thaísa , Alves Marcelli 
Published: June 2020

A proposta deste artigo é apresentar uma revisão teórica sobre a pesquisa de métodos mistos, com o objetivo de lançar luz para o modelo e, possivelmente, instigar sua prática. Autores como Niglas (2004), Bryman (2006), Wooley (2008), Paranhos et al (2016), entre outros, destacam que a triangulação metodológica é um desejo de pesquisadores nas áreas das humanidades e ciências sociais, embora ainda exista muita dificuldade na sua aplicação. Neste sentido, este artigo tenta reunir determinados conceitos e particularidades deste método, a partir de autores que têm se dedicado a esmiuçar a triangulação como um tipo de pesquisa que vai além de puramente incluir etapas variadas de levantamento de dados na investigação: Teddlie, Tashakkori (2006), Small (2011) Oliveira (2015), Creswell (2014), entre outros. A proposta é compilar conceitos e modos de aplicação para servir a um estudo introdutório ao tema.
Assessment of the quality of life of patients on hemodialysis: focus on the northern region
Authors: Vishnyak D. A. , Malashenko S. M. 
Published: June 2020

INTRODUCTION. The registration of late-stage chronic kidney disease (CKD) has increased significantly worldwide in recent years. At the same time, the quality of life of patients has become important. AIM: to determine the features of the quality of life of patients on hemodialysis program, living in the North (on the example of the city of Surgut). PATIENTS AND METHODS. The annual prospective study included 64 patients aged 33 to 68 years treated with hemodialysis for at least 3 months. The quality of life was determined using the Sydney Disease Quality of Life Short Form (KDQOL-SF) questionnaire. RESULTS. Patients on hemodialysis also have low rates of renal-specific scales, as well as additional scales: “General perception of health”. A sharp decrease in the quality of life in patients with dialysis experience of up to 1 year and more than 10 years was revealed. Clusters of the leading scales of the KDQOL-SF questionnaire, determining the quality of life of patients on hemodialysis in Surgut, were identified. CONCLUSION. In patients with programmed hemodialysis, living in the Northern latitudes, there is a comparable with the General data decrease in the General quality of life. In patients of all groups, regardless of gender, age and dialysis experience, the decline in quality of life is mainly due to the physical component. The high level of «Support for dialysis staff» and «Feeling of social support» in patients of Surgut, regardless of the length of dialysis therapy, were determined by the level of economic development of the region.
Comparative Analysis of Linear and Nonlinear Control of Wave Energy Converter for a Force Control Application
Authors: Parwal Arvind , Fregelius Martin , Almeida Pedro , Svensson Olle , Temiz Irina , Oliveira Janaina G. , Boström Cecilia , Leijon Mats 
Published: June 2020

The aim of wave energy converters (WECs) is to harvest the energy from the ocean waves and convert into electricity. Optimizing the generator output is a vital point of research. A WEC behaves as a nonlinear system in real ocean waves and a control that approximates the behaviour of the system is required. In order to predict the behaviour of WEC, a controller is implemented with an aim to track the referenced trajectory for a force control application of the WEC. A neural model is implemented for the system identification and control of the nonlinear process with a neural nonlinear autoregressive moving average exogenous (NARMAX) model. The neural model updates the weights to reduce the error by using the Levenberg-Marquardt back-propagation algorithm for a single-input-single-output (SISO) nonlinear system. The performance of the system under the proposed scheme is compared to the same system under a PI-controller scheme, where the PI gains have been tuned accordingly, to verify the control capacity of the proposed controller. The results show a good tracking of dq (direct-quadrature) axes currents by regulating the stator currents, and hence a force control is achieved at different positions of the translator. The dynamic performance of the control is verified in a time domain analysis for the displacement of the translator.
Abstract Tropical Linear Programming
Authors: Loho Georg 
Published: June 2020

In this paper we develop a combinatorial abstraction of tropical linear programming. This generalizes the search for a feasible point of a system of min-plus-inequalities. We obtain an algorithm based on an axiomatic approach to this generalization. It builds on the introduction of signed tropical matroids based on the polyhedral properties of triangulations of the product of two simplices and the combinatorics of the associated set of bipartite graphs with an additional sign information. Finally, we establish an upper bound for our feasibility algorithm applied to a system of min-plus-inequalities in terms of the secondary fan of a product of two simplices. The appropriate complexity measure is a shortest integer vector in a cone of the secondary fan associated to the system.
Inhomogeneous Partition Regularity
Authors: Leader Imre , Russell Paul A. 
Published: June 2020

We say that the system of equations $Ax = b$, where $A$ is an integer matrix and $b$ is a (non-zero) integer vector, is partition regular if whenever the integers are finitely coloured there is a monochromatic vector $x$ with $Ax = b.$ Rado proved that the system $Ax = b$ is partition regular if and only if it has a constant solution.
Byszewski and Krawczyk asked if this remains true when the integers are replaced by a general (commutative) ring $R$. Our aim in this note is to answer this question in the affirmative. The main ingredient is a new 'direct' proof of Rado’s result.
Evaluation of Seagrass and Seaweed Species Diversity, Abundance, and Human Activities Endangering their Existence at Indian Ocean Shore at Kigamboni in Dar es Salaam City, Coastal Zone of Tanzania
Authors: Kayombo Canisius John , Barnabas Gudrun , Likinguraine Kivuyo 
Published: June 2020

An evaluation of seagrass and seaweed species diversity, abundance, and the human activities endangering their existence were conducted at the Kigamboni Indian ocean shore in Dar es Salaam city. The study aimed to determine the abundance, diversity of seagrasses and seaweeds and to identify human activities undertaken in the study area. A transect was set within the study area where plots of 10 m x 10 m (100 m2) were established at an interval of 100m. The encountered seagrass and seaweed species were identified for their scientific names to species level and whenever it was not possible, a specimen was collected and taken to the University of Dar es Salaam Herbarium (DSM) for identification. The species were also counted and recorded as per their number of stems. H’ was applied to calculate the Shannon Wiener Index of Diversity. Also, relative abundance (RA) was calculated. A total of 17 species from 14 genera were identified. The calculated H’ was 2.0309, an implication of high seagrass and seaweed species diversity. The identified human activities were fishing and swimming. Of those activities, bait collection (33.89%) was the most dominant while swimming had 33.33%, fishing had 16.67% and marine gravel had 11.11%. Kigamboni ocean shore comprises of high species diversity of seagrass and seaweed species, facing severe damage from human disturbances. This study recommends for sustainable management of the ocean shore through education, protection strategy to ensure the survival of the existing seagrasses and seaweed species.