bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH KETINGGIAN TEMPAT TUMBUH DAN PENGERINGAN TERHADAP FLAVONOID TOTAL SAMBANG COLOK (Iresine herbstii)
Authors: Safrina Devi , Priyambodo Wahyu Joko 
Published: May 2020

<p>Sambang Colok (<em>Iresine herbstii</em>) merupakan salah satu tanaman obat yang memberikan efek diuretik, anti-inflamasi, dan antipiretik. Sambang Colok merupakan tanaman yang dapat hidup dari dataran rendah sampai dataran tinggi. Pertumbuhan dan perkembangan tanaman sangat dipengaruhi oleh lingkungan termasuk ketinggian. Proses pembuatan bahan jamu harus memenuhi beberapa kriteria parameter kualitas simplisia diantaranya flavonoid total. Kandungan kimia simplisia sangat dipengaruhi oleh proses pembuatan simplisia salah satunya adalah proses pengeringan. Penelitian ini bertujuan mengetahui pengaruh ketinggian tempat tumbuh dan cara pengeringan terhadap kandungan flavonoid tanaman Sambang Colok. Penelitian yang dilakukan menggunakan variasi ketinggian (1800 mpdl, 1200 mdpl, 600mdpl, dan 200mdpl) serta metode pengeringan (sinar matahari, oven dan kombinasi). Simplisia yang diperoleh selanjutnya dianalisis biomasa dan kadar flavonoid totalnya. Hasil penelitian menunjukkan bahwa terdapat perbedaan yang signifikan pada perlakuan ketinggian dan pengeringan, dimana perlakuan terbaik adalah pada tempat tumbuh dengan ketinggian 1200 mdpl dan pengeringan dengan menggunakan kombinasi sinar matahari dan oven atau pengeringan menggunakan oven</p><p> </p><p><strong>Effect of Altitude and Drying Method on Flavonoid of Sambang Colok<em> (Iresine herbsti)</em></strong></p><p>Sambang colok (<em>Iresine herbstii</em>) is one of the medicinal plants which has diuretic, anti-inflammatory, and antipyretic properties. Sambang colok can live inlowlands and highlands. Plant growth and development is strongly influenced by the environment, including altitude. The process of making herbal medicine materials must meet the quality parameters of simplicia, i.e. total flavonoid content. Chemical content of simplicia is strongly influenced by the manufacturing process, one of which is the drying process. The aim of this research was to study the influence of altitude of planting land and drying methods on flavonoid content of sambang colok. The research was conducted using variations of altitude planting land (1800 masl, 1200 masl, 600masl, and 200masl) as well as the drying method (sun drying, oven drying and combination). Simplicia then analyzed for total biomass and flavonoid content. The result showed that altitude and drying methods gave significant effect on simplicia sambang colok, where the best result for flavonoid content obtained with altitude of 1200 masl and oven drying and combination of drying methods.</p><p><strong><em><br /></em></strong></p>
AUDIT, AUDIT-C y AR2I para evaluar el binge drinking en universitarios españoles
Authors: Botella López Maria , Giménez Costa José Antonio , Cortés Tomás María Teresa 
Published: May 2020

La identificación de los jóvenes que realizan un consumo intensivo de alcohol (CIA) es una prioridad en el ámbito de la prevención e intervención, dadas las consecuencias bio-psico-sociales que genera. Objetivo. Verificar qué versión del AUDIT constituye el instrumento de screening más adecuado en esta población, partiendo de una operacionalización más precisa del CIA. Método. Se ha realizado un muestreo de conveniencia en el que han participado 190 jóvenes consumidores de alcohol entre 18 y 22 años (73.7% mujeres), que cumplimentaron un autoregistro de consumo de alcohol, el AUDIT y AR2I. Resultados. El análisis de conglomerados por sexos muestra 5 grupos de jóvenes CIA, en función de la edad de inicio en el consumo de alcohol y los gramos ingeridos de esta sustancia durante un episodio CIA. De entre las versiones del AUDIT analizadas, la combinación de los ítems 2 y 3 revisados (AR2I) se desmarca como la mejor opción para identificar a este colectivo. Conclusiones. El AR2I resulta la opción más útil, rápida y sencilla de identificación de jóvenes CIA, permitiendo su implementación en contextos como Atención Primaria, Servicios de Urgencias y recursos especializados en prevención de drogas.
Chemsex y conductas sexuales de riesgo en hombres que tienen sexo con hombres: Una revisión sistemática
Authors: Carvalho Gomes Itallo , Gamez-Medina Mario Enrique , Valdez-Montero Carolina 
Published: May 2020

El término chemsex es utilizado para hablar del uso sexualizado de drogas entre los hombres que tienen sexo con hombres (HSH) que sienten la necesidad de incrementar su excitación, placer y su tiempo de duración en las relaciones sexuales. Objetivo. El objetivo del presente trabajo es analizar de manera sistemática la evidencia disponible sobre el chemsex y conductas sexuales de riesgo en HSH. Método. Para la elaboración de esta revisión sistemática se siguió con la formulación de una pregunta, establecimiento de criterios de inclusión y exclusión, desarrollo de estrategias de búsqueda, la selección de artículos para ser incluidos en la revisión, extracción de datos y síntesis de los datos. Resultados. Sobre el chemsex el 25% de los estudios describe el uso recreativo de drogas antes o durante el encuentro sexual y el 12.5% relata que el chemsex implica potenciales riesgos para la salud física y mental de su practicante. El 62.5% de los estudios asocian esa práctica a las fiestas de sexo en grupo. El 62.5% de los estudios encontraron que los homosexuales practican en mayor medida el chemsex comparado con los bisexuales. Conclusiones. La revisión sistemática contribuye a una mayor comprensión acerca del chemsex y las conductas sexuales de riesgo en HSH.
Gender differences and occupational factors for the risk of obesity in the Italian working population
Authors: Tecco Cristina Di , Fontana Luca , Adamo Giovanna , Petyx Marta , Iavicoli Sergio 
Published: May 2020

Abstract
Background Obesity is a multifactorial condition and a major risk factor associated with several non-communicable diseases, such as cardiovascular disease, and with a higher risk of premature death and disability. Sex-specific factors have key roles and must be taken into consideration in studying occupational factors associated with the risk of obesity. The aim of this study was to investigate gender differences in body mass index (BMI) in a large cohort representative of Italian workers and, correlating this index with several demographic and occupational variables, to verify sex- and work-dependent differences in the risk of obesity. Methods We utilized data from INSuLa, a cross-sectional, nationally representative survey of the Italian worker population conducted in 2013 by the Italian Workers’ Compensation Authority to investigate health and safety at work. Analyses were run on a sample of 8,000 Italian workers, aged from 16 to 64 years. Logistic regression models were employed to assess gender differences in the relation between occupational characteristics and BMI. We adjusted for age, education, variables related to health protection at work, and chronic conditions and diseases.Results There were several significant differences in the BMI between males and females, linked to some occupational factors. For instance, female shift workers were 1.32 times (95% CI 1.11-1.57) more likely to be overweight or obese than normal-weight workers, and this association was maintained when controlling for confounders. The likelihood of overweight or obesity among women who worked 1-2 night shifts per week was significantly higher – 1.5-1.6 times – than those on day shifts.Conclusions Gender-specific differences in occupational factors associated with the risk of obesity are useful with a view to characterizing this risk and helping identify workplace-targeted intervention strategies.
Substantial and sustained reduction in under-5 mortality, diarrhea, and pneumonia in Oshikhandass, Pakistan: evidence from two longitudinal cohort studies 15 years apart
Authors: Hansen Chelsea L , McCormick Benjamin JJ , Azam Syed Iqbal , Ahmed Khalil , Baker Julia M , Hussain Ejaz , Jahan Assis , Jamison Alexandra F , Knobler Stacey L , Samji Nahida , Shah Wasiat H , Spiro David J , Thomas Elizabeth D , Viboud Cecile , Rasmussen Zeba A 
Published: May 2020

Abstract
Background: Oshikhandass is a rural village in northern Pakistan where a verbal autopsy study from 1989-1991 showed that diarrhea and pneumonia were the top causes of under-5 mortality. Intensive surveillance, active community health education and child health interventions were delivered in 1989-1996; here we assess improvements in under-5 mortality, diarrhea, and pneumonia over this period and 15 years later.Methods: Two prospective open-cohort studies in Oshikhandass from 1989-1996 (Study 1) and 2011-2014 (Study 2) enrolled all children under age 60 months. Study staff trained using WHO guidelines conducted weekly household surveillance and promoted knowledge on causes and management of diarrhea and pneumonia. Information about household characteristics and socioeconomic status was collected. Hurdle models were constructed to examine putative risk factors for diarrhea and pneumonia.Results: Against a backdrop of considerable change in the socioeconomic status of the community, under-5 mortality, which declined over the course of Study 1 (from 114.3 to 79.5 deaths/1000 live births (LB) between 1989 and 1996), exceeded Sustainable Development Goal 3 by Study 2 (19.8 deaths/ 1000 LB). Reductions in diarrhea prevalence (20.3 to 2.2 days/ Child Year [CY]), incidence (2.1 to 0.5 episodes/ CY), and number of bloody diarrhea episodes (18.6% to 5.2%) seen during Study 1, were sustained in Study 2. Pneumonia incidence was 0.5 episodes /CY in Study 1 and 0.2/CY in Study 2; only 5% of episodes were categorized as severe or very severe in both studies. While no individual factors predicted a statistically significant difference in diarrhea or pneumonia episodes, the combined effect of water, toilet and housing materials was associated with a significant decrease in diarrhea; higher household income was the most protective factor for pneumonia in Study 1. Conclusions: We report a 4-fold decrease in overall childhood mortality, and a 2-fold decrease in childhood morbidity from diarrhea and pneumonia in a remote rural village in Pakistan between 1989-2014. We conclude that significant, sustainable improvements in child health may be achieved through improved socioeconomic status and promoting interactions between locally engaged health workers and the community, but that continued efforts are needed to improve health worker training, supervision, and the rational use of medications.Trial Registration: Not Applicable
Participation of adults with cognitive, physical, or psychiatric impairments in family of origin and intimate relationships: a grounded theory study
Authors: Pfister Andreas , Georgi-Tscherry Pia , Berger Fabian , Studer Michaela 
Published: May 2020

Abstract
Background: How adults with disabilities perceive participation has received little attention. Our purpose was to formulate a grounded theory on participation, based on the subjective experience of adults with cognitive, physical, or psychiatric impairment(s), and to identify barriers, facilitators, and support needs concerning participation in different areas of life. We aimed to explore whether the United Nations’ Convention on the Rights of Persons with Disabilities (CRPD), ratified by Switzerland in 2014, and its principles are being met. Here we report on the main category and focus on the participation areas ‘family of origin’ and ‘intimate relationships.’ Methods: In a qualitative, grounded theory study, we conducted problem-centered interviews with 23 adults with cognitive, physical, or psychiatric impairments (30­-53 years; 11 men, 12 women), with different housing (on their own, assisted living, with parents) and work situations (primary vs. secondary labor market) in nine German-speaking Swiss cantons. Results: Participation can be understood as a continuum that extends on a horizontal level (from participation is restricted to participation takes place) and a vertical level (separative setting vs. inclusive setting). In separative as well as in inclusive settings, diverse levels of participation are possible. Many participants were stuck in an ‘in-between’ area between separative and inclusion-oriented settings. In the family of origin, there was a thin line between fulfilling relations that enhance participation and conflictual relations and overprotective parenting that limit participation. In intimate relationships, opportunities for participation were limited overall. Many interviewees were single. Social environment and family of origin (e.g., parents) can enable and facilitate intimate relationships and sexual contacts but can also be an important barrier.Conclusions: Participation can be understood as a continuum. Participation restrictions exist in separative as well as in inclusive-oriented settings, also in the areas of family of origin and intimate relationships. Participation barriers must be torn down in separative as well as in inclusion-oriented settings. Trajectories to inclusive settings should be facilitated. Families with children with impairment(s) should be supported from early on to create the best possible participation possibilities for the (adult) person with impairment(s) and to support the family of origin itself.
Robotic, laparoscopic or open hemihepatectomy for giant liver haemangiomas over 10 cm in diameter
Authors: Hu Minggen , Chen Kuang , Zhang Xuan , Li Chenggang , Song Dongda , Liu Rong 
Published: May 2020

Abstract
Background: To evaluate the clinical efficacy of robotic, laparoscopic, and open hemihepatectomy for giant liver haemangiomas.Methods: From April 2011 to April 2017, consecutive patients who underwent hemihepatectomy for giant liver haemangiomas were included in this study. According to the type of operation, these patients were divided into the robotic hemihepatectomy (RH) group, the laparoscopic hemihepatectomy (LH) group, and the open hemihepatectomy (OH) group. The perioperative and short-term postoperative outcomes were compared among the three groups. The study was reported following the STROCSS criteria.Results: There were no significant differences in age, sex, tumour location, body surface area (BSA), future liver remnant volume (FLR), standard liver volume (SLV), liver haemangioma volume, FLR/SLV, resected normal liver volume/resected volume, hepatic disease, rates of blood transfusion, liver function after 24 hours of surgery, operative morbidity and mortality among the three groups. Compared with patients in the RH group (n=19) and the LH group (n=13), patients in the OH group (n=25) had a significantly longer postoperative hospital stay (P< 0.05), time to oral intake (P < 0.05), and time to get-out-of-bed (P < 0.05); a higher VAS score after 24 hours of surgery (P < 0.05); and a shorter operative time (P < 0.05). There were no significant differences in these postoperative outcomes (P＞0.05) between the RH group and the LH group. When the setup time in the RH group was excluded, the operative time in the RH group was significantly shorter than that in the LH group (P＜0.05). There was no significant difference in the operative time between the RH group and the OH group (P＞0.05). The amount of intraoperative blood loss in the RH group was the lowest among the three groups (P＜0.05), and the amount of intraoperative blood loss in the LH group was less than that in the OH group (P＜0.05).Conclusion: Robotic and laparoscopic hemihepatectomies were associated with less intraoperative blood loss,better postoperative recovery and lower pain score. Compared with laparoscopic hemihepatectomy, robotic hemihepatectomy was associated with significantly less intraoperative blood loss and a shorter operative time.
Large mid-upper arm circumference is associated with metabolic syndrome in middle-aged and elderly individuals: a community-based study
Authors: Shi Jie , Yang Zhen , Niu Yixin , Zhang Weiwei , Li Xiaoyong , Zhang Hongmei , Lin Ning , Gu Hongxia , Wen Jie , Ning Guang , Qin Li , Su Qing 
Published: May 2020

Abstract
Background The mid-upper arm circumference (MUAC) is a proxy for subcutaneous fat in the upper body and is a reliable screening measure for identifying individuals with abnormal regional fat distribution. The purpose of this study was to evaluate the association between MUAC and metabolic syndrome (MetS) in middle-aged and elderly individuals.Methods We measured the MUAC in a cross-sectional sample with a total of 9787 subjects aged 40 years and older. The measurement of MUAC is performed on the right arm using a non‐elastic tape held midway between the acromion and the olecranon processes in duplicate, with the arm hanging loosely at the side of the body. The MetS was defined according to the Joint Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention.Results MUAC was positively correlated with waist circumference (r=0.437, P<0.001), BMI (r=0.334, P<0.001), fasting insulin (r=0.348, P<0.001), HOMA-IR (r=0.134, P< 0.001), triglycerides (r=0.138, P<0.001), SBP (r=0.124, P< 0.001), and DBP (r= 0.123, P<0.001), and inversely correlated with adiponectin (r=-0.147, P < 0.001) and HDL-cholesterol (r=-0.176, P<0.001) after adjusting for age and gender. Compared with the lowest quartile group, the odds ratios were substantially higher for MetS (OR 1.77; 95% CI 1.51-2.09, P for trend<0.001) in the highest MUAC quartile group after adjustment for potential cofounder.Conclusion Large mid-upper arm circumference is significantly associated with metabolic syndrome in middle-aged and elderly individuals.
Identification of transcription factors MYC and C/EBPβ mediated regulatory networks in heart failure based on Gene Expression Omnibus datasets
Authors: Wang Haiwei , Wang Xinrui , Xu Liangpu , Cao Hua 
Published: May 2020

Abstract
Background: Heart failure is one of leading cause of death worldwide. However, the transcriptional profiling of heart failure is unclear. Moreover, the signaling pathways and transcription factors involving the heart failure development also are largely unknown. Using published Gene Expression Omnibus (GEO) datasets, in the present study, we aim to comprehensively analyze the differentially expressed genes in failing heart tissues, and identified the critical signaling pathways and transcription factors involving heart failure development.Methods: The transcriptional profiling of heart failure was identified from previously published gene expression datasets deposited in GSE5406, GSE16499 and GSE68316. The enriched signaling pathways and transcription factors were analyzed using Database for Annotation, Visualization and Integrated Discovery (DAVID) website and gene set enrichment analysis (GSEA) assay. The transcriptional networks were created by Cytoscape.Results: Compared with the normal heart tissues, 90 genes were particularly differentially expressed in failing heart tissues, and those genes were associated with multiple metabolism signaling pathways and insulin signaling pathway. Metabolism and insulin signaling pathway were both inactivated in failing heart tissues. Transcription factors MYC and C/EBPβ were both negatively associated with the expression profiling of failing heart tissues in GSEA assay. Moreover, compared with normal heart tissues, MYC and C/EBPβ were down regulated in failing heart tissues. Furthermore, MYC and C/EBPβ mediated downstream target genes were also decreased in failing heart tissues. MYC and C/EBPβ were positively correlated with each other. At last, we constructed MYC and C/EBPβ mediated regulatory networks in failing heart tissues, and identified the MYC and C/EBPβ target genes which had been reported involving the heart failure developmental progress.Conclusions: Our results suggested that metabolism pathways and insulin signaling pathway, transcription factors MYC and C/EBPβ played critical roles in heart failure developmental progress.
Epidemiology of neonatal infections in hospitals of Nepal: Evidence from a large- scale study
Authors: Budhathoki Shyam Sundar , Sunny Avinash K , Paudel Pragya Gautam , Thapa Jeevan , Basnet Lila Bahadur , Karki Sandeepa , Gurung Rejina , Paudel Prajwal , Kc Ashish 
Published: May 2020

Abstract
Background: Every year, neonatal infections account for approximately 750,000 neonatal deaths globally. It is the third major cause of neonatal death, globally and in Nepal. There is a paucity of data on clinical aetiology and outcomes of neonatal infection in Nepal. This paper aims to assess the incidence and risk factors of neonatal infection in babies born in public hospitals of Nepal.Methods: This is a prospective cohort study conducted for a period of 14 months, nested within a large-scale cluster randomized control trial which evaluated the Helping Babies Breathe Quality Improvement package in 12 public hospitals in Nepal. All the mothers who consented to participate within the study and delivered in these hospitals were included in the analysis. All neonates admitted into the sick newborn care unit weighing >1500 gram or/and 32 weeks or more gestation with clinical signs of infection or positive septic screening were taken as cases and those that did not have an infection were the comparison group. Bivariate and multi-variate analysis of socio-demographic, maternal, obstetric and neonatal characteristics of case and comparison group were conducted to assess risk factors associated with neonatal infection. Results: The overall incidence of neonatal infection was 7.3 per 1000 live births. Babies who were born to first time mothers were at 64% higher risk of having infection (aOR-1.64, 95% CI, 1.30-2.06, p-value<0.001). Babies born to mothers who had no antenatal check-up had more than three-fold risk of infection (aOR-3.45, 95% CI, 1.82-6.56, p-value<0.001). Babies born through caesarean section had more than two-fold risk (aOR-2.06, 95% CI, 1.48-2.87, p-value<0.001) and babies with birth asphyxia had more than three-fold risk for infection (aOR-3.51, 95% CI, 1.71-7.20, p-value=0.001).Conclusion : Antepartum factors, such as antenatal care attendance, and intrapartum factors such as mode of delivery and birth asphyxia, were risk factors for neonatal infections. These findings highlight the importance of ANC visits and the need for proper care during resuscitation in babies with birth asphyxia.