bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling a Hydrodynamic Bearing With Provision for Misalignments and Textures
Authors: Gu Chunxing , Meng Xianghui , Wang Shuwen , Ding Xiaohong 
Published: November 2019

Abstract
Surface texturing is one effective means to improve bearing performance. Available studies are mainly focused on the perfectly aligned journal bearing with textures. The studies involving the effect of surface texturing on the misaligned bearing are still limited. In the present study, a transient mixed lubrication model that allows predicting evolution of friction characteristics with high efficiency was proposed. The misalignment of journal bearing under the time-varying applied load was considered using two deflection angles. The performance of journal bearing with provision for misalignments and textures was studied using the proposed model. The results involving the orbits of the journal center and the energy loss of different misaligned journal bearings were obtained. The influences of misalignment degree and surface texturing on these parameters were analyzed. The results show that along with the increased deflection angles, the effect of texturing on the tribological performance of journal bearing would turn beneficial into harmful.
The Role of Reynolds Number Effect and Tip Leakage in Compressor Geometry Scaling at Low Turbulent Reynolds Numbers
Authors: Diehl Markus , Schreiber Christoph , Schiffmann Jürg 
Published: November 2019

Abstract
In compressor design, a convenient way to save time is to scale an existing geometry to required specifications, rather than developing a new design. The approach works well when scaling compressors of similar size at high Reynolds numbers but becomes more complex when applied to small-scale machines. Besides the well-understood increase in surface friction due to increased relative surface roughness, two other main problems specific to small-scale turbomachinery can be specified: (1) the Reynolds number effect, describing the non-linear dependency of surface friction on Reynolds number and (2) increased relative tip clearance resulting from manufacturing limitations. This paper investigates the role of both effects in a geometric scaling process, as used by a designer. The work is based on numerical models derived from an experimentally validated geometry. First, the effects of geometric scaling on compressor performance are assessed analytically. Second, prediction capabilities of reduced-order models from the public domain are assessed. In addition to design point assessment, often found in other publications, the models are tested at off-design. Third, the impact of tip leakage on compressor performance and its Reynolds number dependency is assessed. Here, geometries of different scale and with different tip clearances are investigated numerically. Fourth, a detailed investigation regarding tip leakage driving mechanisms is carried out and design recommendations to improve small-scale compressor performance are provided.
Effect of Turbine Blade Tip Cooling Configuration on Tip Leakage Flow and Heat Transfer
Authors: Sakaoglu Sergen , Kahveci Harika S. 
Published: November 2019

Abstract
The pressure difference between suction and pressure sides of a turbine blade leads to tip leakage flow, which adversely affects the first-stage high-pressure (HP) turbine blade tip aerodynamics. In modern gas turbines, HP turbine blade tips are exposed to extreme thermal conditions requiring cooling. If the coolant jet directed into the blade tip gap cannot counter the leakage flow, it will simply add up to the pressure losses due to leakage. Therefore, the compromise between the aerodynamic loss and the gain in tip-cooling effectiveness must be optimized. In this paper, the effect of tip-cooling configuration on the turbine blade tip is investigated numerically from both aerodynamics and thermal aspects to determine the optimum configuration. Computations are performed using the tip cross section of GE-E3 HP turbine first-stage blade for squealer and flat tips, where the number, location, and diameter of holes are varied. The study presents a discussion on the overall loss coefficient, total pressure loss across the tip clearance, and variation in heat transfer on the blade tip. Increasing the coolant mass flow rate using more holes or by increasing the hole diameter results in a decrease in the area-averaged Nusselt number on the tip floor. Both aerodynamic and thermal response of squealer tips to the implementation of cooling holes is superior to their flat counterparts. Among the studied configurations, the squealer tip with a larger number of cooling holes located toward the pressure side is highlighted to have the best cooling performance.
Postexercise Glucose–Fructose Coingestion Augments Cycling Capacity During Short-Term and Overnight Recovery From Exhaustive Exercise, Compared With Isocaloric Glucose
Authors: Gray Edward A. , Green Thomas A. , Betts James A. , Gonzalez Javier T. 
Published: November 2019

During short-term recovery, postexercise glucose–fructose coingestion can accelerate total glycogen repletion and augment recovery of running capacity. It is unknown if this advantage translates to cycling, or to a longer (e.g., overnight) recovery. Using two experiments, the present research investigated if postexercise glucose–fructose coingestion augments exercise capacity following 4-hr (short experiment; n = 8) and 15-hr (overnight experiment; n = 8) recoveries from exhaustive exercise in trained cyclists, compared with isocaloric glucose alone. In each experiment, a glycogen depleting exercise protocol was followed by a 4-hr recovery, with ingestion of 1.5 or 1.2 g·kg−1·hr−1 carbohydrate in the short experiment (double blind) and the overnight experiment (single blind), respectively. Treatments were provided in a randomized order using a crossover design. Four or fifteen hours after the glycogen depletion protocol, participants cycled to exhaustion at 70% Wmax or 65% Wmax in the short experiment and the overnight experiment, respectively. In both experiments there was no difference in substrate oxidation or blood glucose and lactate concentrations between treatments during the exercise capacity test (trial effect, p > .05). Nevertheless, cycling capacity was greater in glucose + fructose versus glucose only in the short experiment (28.0 ± 8.4 vs. 22.8 ± 7.3 min, d = 0.65, p = .039) and the overnight experiment (35.9 ± 10.7 vs. 30.6 ± 9.2 min, d = 0.53, p = .026). This is the first study to demonstrate that postexercise glucose–fructose coingestion enhances cycling capacity following short-term (4 hr) and overnight (15 hr) recovery durations. Therefore, if multistage endurance athletes are ingesting glucose for rapid postexercise recovery then fructose containing carbohydrates may be advisable.
Infantile acute liver failure in the West of Scotland
Authors: Wands David , Tayler Rachel , Kelly Deirdre , Pinto Fernando , Simpson Judith Helen , Hansen Richard 
Published: November 2019

BackgroundOur current understanding regarding the aetiology of infantile acute liver failure largely derives from studies conducted by regional liver units. This may introduce selection bias and therefore not provide a true reflection of the wider population.MethodsEvery coagulation screen with a prothrombin time ≥18 s in our centre was examined over one calendar year. All patients less than 1 year of age were included and their electronic records retrospectively reviewed.Results24 patients were identified, from 9989 coagulation screens, that fit the current definition of acute liver failure. Hypoxic birth injury and ischaemic events were the most common aetiologies. Survival was 75%.ConclusionThe ‘catch-all’ methodology employed demonstrated that acute liver failure is more common than previously reported and suggests that current data may exclude large numbers who either have more minor self-resolving disease or conversely have severe disease leading to death prior to transfer.
Prevalence and incidence of age-related macular degeneration in Europe: a systematic review and meta-analysis
Authors: Li Jeany Q , Welchowski Thomas , Schmid Matthias , Mauschitz Matthias Marten , Holz Frank G , Finger Robert P 
Published: November 2019

Background/AimsAge-related macular degeneration (AMD) is the main cause of visual impairment and blindness in Europe. A further increase in the number of affected persons is expected and current European data are needed for healthcare resource planning.MethodsWe performed a systematic review on the prevalence and incidence of AMD based on the meta-analysis of observational studies in epidemiology guideline. Meta-analysis and meta-regression on time-trends, age, countries, regions, sex and classification systems for AMD were performed. Based on Eurostat population projections, the pooled prevalence estimates were extrapolated to the year 2050.ResultsTwenty-two prevalence and four incidence studies published since 1996 were included. Our pooled prevalence estimate of early or intermediate AMD and any late AMD in those 60 years and older was 25.3% (95% CI 18.0% to 34.4%) and 2.4% (95% CI 1.8% to 3.3%), respectively. A significant increase in prevalence was seen in older populations. In the meta-analysis of incidence, the pooled annual incidence of any late AMD was 1.4 per 1 000 individuals (95% CI 0.8 to 2.6). Overall, the number of EU inhabitants with any AMD is expected to increase from 67 to 77 million until 2050. Incident late AMD is estimated to increase from 400 000 per year today to 700 000 per year in 2050.ConclusionsApproximately 67 million people in the EU are currently affected by any AMD and, due to population ageing, this number is expected to increase by 15% until 2050. Monitoring and treatment of people with advanced disease stages will require additional healthcare resources and thorough healthcare planning in the years and decades to come.
The burden of anaemia among displaced women and children in refugee settings worldwide, 2013–2016
Authors: Kay Ariel , Leidman Eva , Lopez Velma , Wilkinson Caroline , Tondeur Melody , Bilukha Oleg 
Published: November 2019

IntroductionDisplaced persons have a unique risk for developing anaemia due to often limited diets, overcrowding, new infections and inadequate sanitation and hygiene. The lack of anaemia prevalence estimates among the displaced inhibit global planning for anaemia reduction.MethodsWe analysed population representative, cross-sectional nutrition surveys from 2013 to 2016 conducted by the United Nations High Commissioner for Refugees and partner agencies. Included surveys measured haemoglobin concentration among children 6–59 months, non-pregnant women 15–49 years, or both groups. For each survey, we calculated mean haemoglobin and prevalence of total anaemia (<110 g/L in children, <120 g/L in women), and classified public health severity following WHO guidelines. Pearson correlations between indicators from women and children surveys were calculated where both subpopulations were measured.ResultsAnalysis included 196 surveys among children and 184 surveys among women from 121 unique refugee settings in 24 countries. The median prevalence of total anaemia in children and women was 44% and 28%, respectively. Sixty-one per cent of child surveys indicated a problem of severe public health importance compared with 25% of surveys in women. The prevalence of total anaemia in children and women was strongly correlated (ρ=0.80). Median prevalence of total anaemia was approximately 55% greater and mean haemoglobin was 6 g/L lower among children age 6–23 months compared with children 24–59 months. West and Central Africa region had the highest median prevalence of anaemia both in women and children.ConclusionWhile the burden of anaemia is high among the displaced, it mirrors that of the general population. Haemoglobin should continue to be measured in nutrition surveys in refugee settings. Sustained, multisectoral efforts to reduce anaemia are needed, with specific focus on children under 2 years of age and refugee settings in the West and Central Africa region.
Patient and healthcare provider knowledge, attitudes and barriers to handover and healthcare communication during chronic disease inpatient care in India: a qualitative exploratory study
Authors: Humphries Claire , Jaganathan Suganthi , Panniyammakal Jeemon , Singh Sanjeev K , Goenka Shifalika , Dorairaj Prabhakaran , Gill Paramjit , Greenfield Sheila , Lilford Richard , Manaseki-Holland Semira 
Published: November 2019

Objectives1) To investigate patient and healthcare provider (HCP) knowledge, attitudes and barriers to handover and healthcare communication during inpatient care. 2) To explore potential interventions for improving the storage and transfer of healthcare information.DesignQualitative study comprising 41 semi-structured, individual interviews and a thematic analysis using the Framework Method with analyst triangulation.SettingThree public hospitals in Himachal Pradesh and Kerala, India.ParticipantsParticipants included 20 male (n=10) and female (n=10) patients with chronic non-communicable disease (NCD) and 21 male (n=15) and female (n=6) HCPs. Purposive sampling was used to identify patients with chronic NCDs (cardiovascular disease, chronic respiratory disease, diabetes or hypertension) and HCPs.ResultsPatient themes were (1)public healthcare service characteristics, (2)HCP to patient communicationand (3)attitudes regarding medical information. HCP themes were (1)system factors, (2)information exchange practicesand (3)quality improvement strategies. Both patients and HCPs recognised public healthcare constraints that increased pressure on hospitals and subsequently limited consultation times. Systemic issues reported by HCPs were a lack of formal handover systems, training and accessible hospital-based records. Healthcare management communication during admission was inconsistent and lacked patient-centredness, evidenced by varying reports of patient information received and some dissatisfaction with lifestyle advice. HCPs reported that the duty of writing discharge notes was passed from senior doctors to interns or nurses during busy periods. A nurse reported providing predominantly verbal discharge instructions to patients. Patient-held medical documents facilitated information exchange between HCPs, but doctors reported that they were not always transported. HCPs and patients expressed positive views towards the idea of introducing patient-held booklets to improve the organisation and transfer of medical documents.ConclusionsHandover and healthcare communication during chronic NCD inpatient care is currently suboptimal. Structured information exchange systems and HCP training are required to improve continuity and safety of care during critical transitions such as referral and discharge. Our findings suggest that patient-held booklets may also assist in enhancing handover and patient-centred practices.
Perineural local anaesthetic catheter after major lower limb amputation trial (PLACEMENT): results from a randomised controlled feasibility trial
Authors: Bosanquet David C , Ambler Graeme K , Waldron Cherry-Ann , Thomas-Jones Emma , Brookes-Howell Lucy , Kelson Mark , Pickles Timothy , Harris Debbie , Milosevic Sarah , Fitzsimmons Deborah , Saxena Neeraj , Twine Christopher P 
Published: November 2019

ObjectivesTo determine the feasibility of undertaking a randomised controlled effectiveness trial evaluating the use of a perineural catheter (PNC) after major lower limb amputation with postoperative pain as the primary outcome.DesignRandomised controlled feasibility trial.SettingTwo vascular Centres in South Wales, UK.Participants50 patients scheduled for major lower limb amputation (below or above knee) for complications of peripheral vascular disease.InterventionsThe treatment arm received a PNC placed adjacent to the sciatic or tibial nerve at the time of surgery, with continuous infusion of levobupivacaine hydrochloride 0.125% for up to 5 days. The control arm received neither local anaesthetic nor PNC. Both arms received usual perioperative anaesthesia and postoperative analgesia.Primary and secondary outcome measuresThe primary outcomes were the proportion of eligible patients who were randomised and the proportion of recruited patients who provided primary effectiveness outcome data. Secondary outcomes were: the proportion of recruited patients reaching 2 and 6 month follow-up and supplying pain data; identification of key cost drivers; development of an economic analysis framework for a future effectiveness trial; identification of barriers to recruitment and site set-up; and identification of the best way to measure postoperative pain.ResultsSeventy-six of 103 screened patients were deemed eligible over a 10 month period. Fifty (64.5%) of these patients were randomised, with one excluded in the perioperative period. Forty-five (91.3%) of 49 recruited patients provided enough pain scores on a 4-point verbal rating scale to allow primary effectiveness outcome evaluation. Attrition rates were high; 18 patients supplied data at 6 month follow-up. Costs were dominated by length of hospital stay. Patients and healthcare professionals reported that trial processes were acceptable.ConclusionsRecruitment of patients into a trial comparing PNC use to usual care after major lower limb amputation with postoperative pain measured on a 4-point verbal rating scale is feasible. Evaluation of longer-term symptoms is difficult.Trial registration numberISRCTN: 85 710 690. EudraCT: 2016-003544-37.
Social participation and the combination of future needs for long-term care and mortality among older Japanese people: a prospective cohort study from the Aichi Gerontological Evaluation Study (AGES)
Authors: Takahashi Sei , Ojima Toshiyuki , Kondo Katsunori , Shimizu Sayaka , Fukuhara Shunichi , Yamamoto Yosuke 
Published: November 2019

ObjectivesOur study aimed to examine the longitudinal association between social participation and both mortality and the need for long-term care (LTC) simultaneously.DesignA prospective cohort study with 9.4 years of follow-up.SettingSix Japanese municipalities.ParticipantsThe participants were 15 313 people who did not qualify to receive LTC insurance at a baseline based on the data from the Aichi Gerontological Evaluation Study (AGES, 2003–2013). They received a questionnaire to measure social participation and other potential confounders. Social participation was defined as participating in at least one organisation from eight categories.Primary and secondary outcome measuresThe primary outcomes were classified into three categories at the end of the 9.4 years observational period: living without the need for LTC, living with the need for LTC and death. We estimated the adjusted OR (AOR) using multinomial logistic regression analyses with adjustment for possible confounders.ResultsThe primary analysis included 9741 participants. Multinomial logistic regression analysis revealed that social participation was associated with a significantly lower risk of the need for LTC (AOR 0.82, 95% CI 0.69 to 0.97) or death (AOR 0.78, 95% CI 0.70 to 0.88).ConclusionsSocial participation may be associated with a decreased risk of the need for LTC and mortality among elderly patients.
Relieving acute pain (RAP) study: a proof-of-concept protocol for a randomised, double-blind, placebo-controlled trial
Authors: Colloca Luana , Lee Se Eun , Luhowy Meghan Nichole , Haycock Nathaniel , Okusogu Chika , Yim Soojin , Raghuraman Nandini , Goodfellow Robert , Murray Robert Scott , Casper Patricia , Lee Myounghee , Scalea Thomas , Fouche Yvette , Murthi Sarah 
Published: November 2019

IntroductionPhysicians and other prescribing clinicians use opioids as the primary method of pain management after traumatic injury, despite growing recognition of the major risks associated with usage for chronic pain. Placebos given after repeated administration of active treatments can acquire medication-like effects based on learning mechanisms. This study hypothesises that dose-extending placebos can be an effective treatment in relieving clinical acute pain in trauma patients who take opioids.Methods and analysisThe relieving acute pain is a proof-of-concept randomised, placebo-controlled, double-blinded, single-site study enrolling 159 participants aged from 18 to 65 years with one or more traumatic injuries treated with opioids. Participants will be randomly assigned to three different arms. Arm 1 will receive the full dose of opioids with non-steroidal anti-inflammatory drugs (NSAIDs). Arm 2 will receive the 50% overall reduction in opioid dosage, dose-extending placebos and NSAIDs. Arm 3 (control) will receive NSAIDs and placebos. The trial length will be 3 days of hospitalisation (phase I) and 2-week, 1-month, 3-month and 6-month follow-ups (exploratory phase II). Primary and secondary outcomes include feasibility and acceptability of the study. Pain intensity, functional pain, emotional distress, rates of rescue therapy requests and patient-initiated medication denials will be collected.Ethics and disseminationAll activities associated with this protocol are conducted in full compliance with the Institutional Review Board policies and federal regulations. Publishing this study protocol will enable researchers and funding bodies to stay up to date in their fields by providing exposure to research activity that may not otherwise be widely publicised.Date and protocol version identifier3/6/2019 (HP-00078742).Trial registration numberNCT03426137.
Examining risk factors for self-harm and suicide in LGBTQ+ young people: a systematic review protocol
Authors: Williams A Jess , Arcelus Jon , Townsend Ellen , Michail Maria 
Published: November 2019

IntroductionYoung people who identify as Lesbian, Gay, Bisexual, Transgender, Queer or Questioning (LGBTQ+) are at increased risk for self-harm, suicide ideation and behaviours. However, there has yet to be a comprehensive understanding of what risk factors influence these behaviours within LGBTQ+ young people as a whole. The purpose of this systematic review is to examine risk factors associated with self-harm, suicidal ideation and behaviour in LGBTQ+) young people.Methods and analysisA systematic review will be conducted, conforming to the reporting guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement recommendations. Electronic databases (MEDLINE, Scopus, EMBASE, PsycINFO and Web of Science) will be systematically searched for cross-sectional, prospective, longitudinal, cohort and case–control designs which examine risk factors for self-harm and/or suicidal ideation and behaviour in LGBTQ+ young people (aged 12–25 years). Only studies published in English will be included. No date restrictions will be applied. Study quality assessment will be conducted using the original and modified Newcastle-Ottawa Scales. Meta-analysis or narrative synthesis will be used, dependent on findings.Ethics and disseminationThis is a systematic review of published literature and thereby ethical approval was not sought. The review will be submitted to a peer-reviewed journal, be publicly disseminated at conferences focusing on mental health, self-harm and suicide prevention. The findings will also be shared through public engagement and involvement, particularly those related to young LGBTQ+ individuals.PROSPERO registration numberCRD42019130037.