bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corporate power and the international trade regime preventing progressive policy action on non-communicable diseases: a realist review
Authors: Milsom Penelope , Smith Richard , Baker Phillip , Walls Helen 
Published: October 2020

AbstractTransnational tobacco, alcohol and ultra-processed food corporations use the international trade regime to prevent policy action on non-communicable diseases (NCDs); i.e. to promote policy ‘non-decisions’. Understanding policy non-decisions can be assisted by identifying power operating in relevant decision-making spaces, but trade and health research rarely explicitly engages with theories of power. This realist review aimed to synthesize evidence of different forms and mechanisms of power active in trade and health decision-making spaces to understand better why NCD policy non-decisions persist and the implications for future transformative action. We iteratively developed power-based theories explaining how transnational health-harmful commodity corporations (THCCs) utilize the international trade regime to encourage NCD policy non-decisions. To support theory development, we also developed a conceptual framework for analysing power in public health policymaking. We searched six databases and relevant grey literature and extracted, synthesized and mapped the evidence against the proposed theories. One hundred and four studies were included. Findings were presented for three key forms of power. Evidence indicates THCCs attempt to exercise instrumental power by extensive lobbying often via privileged access to trade and health decision-making spaces. When their legitimacy declines, THCCs have attempted to shift decision-making to more favourable international trade legal venues. THCCs benefit from structural power through the institutionalization of their involvement in health and trade agenda-setting processes. In terms of discursive power, THCCs effectively frame trade and health issues in ways that echo and amplify dominant neoliberal ideas. These processes may further entrench the individualization of NCDs, restrict conceivable policy solutions and perpetuate policymaking norms that privilege economic/trade interests over health. This review identifies different forms and mechanisms of power active in trade and health policy spaces that enable THCCs to prevent progressive action on NCDs. It also points to potential strategies for challenging these power dynamics and relations.
Parasite Viability as a Superior Measure of Antimalarial Drug Activity in Humans
Authors: Rebelo Maria , Pawliw Rebecca , Gower Jeremy , Webb Lachlan , Mitchell Hayley , Pava Zuleima , Watts Rebecca E , Davenport Miles P , McCarthy James S , Khoury David S 
Published: October 2020

Abstract

Background
Artemisinin derivatives are the leading class of antimalarial drugs due to their rapid onset of action and rapid clearance of circulating parasites. The parasite clearance half-life measures the rate of loss of parasites from blood after treatment, and this is currently used to assess antimalarial activity of novel agents and to monitor resistance. However, a number of recent studies have challenged the use of parasite clearance to measure drug activity, arguing that many circulating parasites may be nonviable.

Methods
Plasmodium falciparum–infected subjects (n = 10) in a malaria volunteer infection study were administered a single dose of artesunate (2 mg/kg). Circulating parasite concentration was assessed by means of quantitative polymerase chain reaction (qPCR). Parasite viability after artesunate administration was estimated by mathematical modeling of the ex vivo growth of parasites collected from subjects.

Results
We showed that in artemisinin-sensitive infection, viable parasites declined to &lt;0.1% of baseline within 8 hours after artesunate administration, while the total number of circulating parasites measured with quantitative polymerase chain reaction remained unchanged. In artemisinin-resistant infections over the same interval, viable parasites declined to 51.4% (standard error of the mean, 4.6%) of baseline.

Conclusions
These results demonstrate that in vivo drug activity of artesunate is faster than is indicated by the parasite clearance half-life.
Serological Evidence of Human Infection With Avian Influenza A(H7N9) Virus: A Systematic Review and Meta-analysis
Authors: Wang Wei , Chen Xinhua , Wang Yan , Lai Shengjie , Yang Juan , Cowling Benjamin J , Horby Peter W , Uyeki Timothy M , Yu Hongjie 
Published: October 2020

AbstractBackgroundThe extent of human infections with avian influenza A(H7N9) virus, including mild and asymptomatic infections, is uncertain.MethodsWe performed a systematic review and meta-analysis of serosurveys for avian influenza A(H7N9) virus infections in humans published during 2013–2020. Three seropositive definitions were assessed to estimate pooled seroprevalence, seroconversion rate, and seroincidence by types of exposures. We applied a scoring system to assess the quality of included studies.ResultsOf 31 included studies, pooled seroprevalence of A(H7N9) virus antibodies from all participants was 0.02%, with poultry workers, close contacts, and general populations having seroprevalence of 0.1%, 0.2%, and 0.02%, respectively, based on the World Health Organization (WHO)—recommended definition. Although most infections were asymptomatic, evidence of infection was highest in poultry workers (5% seroconversion, 19.1% seroincidence per 100 person-years). Use of different virus clades did not significantly affect seroprevalence estimates. Most serological studies were of low to moderate quality and did not follow standardized seroepidemiological protocols or WHO-recommended laboratory methods.ConclusionsHuman infections with avian influenza A(H7N9) virus have been uncommon, especially for general populations. Workers with occupational exposures to poultry and close contacts of A(H7N9) human cases had low risks of infection.
Bayesian estimation of the seroprevalence of antibodies to SARS-CoV-2
Authors: Dong Qunfeng , Gao Xiang 
Published: October 2020

Abstract
Accurate estimations of the seroprevalence of antibodies to severe acute respiratory syndrome coronavirus 2 need to properly consider the specificity and sensitivity of the antibody tests. In addition, prior knowledge of the extent of viral infection in a population may also be important for adjusting the estimation of seroprevalence. For this purpose, we have developed a Bayesian approach that can incorporate the variabilities of specificity and sensitivity of the antibody tests, as well as the prior probability distribution of seroprevalence. We have demonstrated the utility of our approach by applying it to a recently published large-scale dataset from the US CDC, with our results providing entire probability distributions of seroprevalence instead of single-point estimates. Our Bayesian code is freely available at https://github.com/qunfengdong/AntibodyTest.
Growth performance and hematological changes of weaned beef calves diagnosed with respiratory disease using respiratory scoring and thoracic ultrasonography
Authors: Cuevas-Gómez Inmaculada , McGee Mark , McCabe Matthew , Cormican Paul , O’Riordan Edward , McDaneld Tara , Earley Bernadette 
Published: October 2020

AbstractThis study investigated 1) the effect of clinical bovine respiratory disease (BRD) and associated lung consolidations on growth performance and hematological profiles of recently weaned beef calves and 2) the relationship between clinical respiratory signs and lung consolidation detected by thoracic ultrasonography (TUS). One hundred and fifty-three weaned beef calves (209 days old [SD: 35.8] and 306 kg [SD: 26.3], at arrival) purchased and transported from auction markets were accommodated indoors in concrete slatted floor pens. Calves were weighed weekly from arrival until day 28 and on day 65 post-arrival. Assessment of BRD and blood sample collection for hematological profiles were performed on scheduled days (at arrival, on days 7, 14, and 28) and on other days upon BRD diagnosis. Animals were assessed for BRD using a total clinical respiratory score (CRS) of five clinical signs (rectal temperature, ear position, cough, nasal secretion, and eye secretion with each ranging from normal [0] to abnormal [3]) and TUS scores (normal [0] to lung consolidation ≥ 1 cm2 [2]). Based on CRS, 35% of calves were CRS+ (CRS ≥ 5) and 65% were CRS− (CRS &lt; 5). Although no lung consolidations (TUS−) were detected at arrival, 34% of calves developed lung consolidation (≥1 cm2) (TUS+) during the first 28 d post-arrival. Only fever (&gt;39.6 °C) and nasal discharge were weakly associated (r = 0.19, P &lt;0.05) with lung consolidation. On the day of BRD detection, neutrophil number and neutrophil:lymphocyte ratio were 58% and 73% greater, respectively, in BRD calves with lung consolidation compared with healthy calves. From day 0 to 65, calf average daily gain (ADG) did not differ (P &gt;0.05) between CRS+ and CRS− calves but was 0.09 kg/d lower (P &lt; 0.05) for TUS+ compared with TUS− calves. Calves classified as BRD (CRS + TUS ≥ 5) with lung consolidation had lower (P &lt; 0.05) ADG from arrival until day 28 than healthy calves and BRD calves without lung consolidation (0.11 ± 0.10 vs. 0.53 ± 0.07 vs. 0.57 ± 0.10 kg/d, respectively); however, no differences in ADG were observed from day 0 to 65. Conventional methods to diagnose BRD failed to detect calves with lung lesions. TUS is a useful tool to detect lung lesions and its implementation in combination with CRS should provide a more accurate and early diagnosis of BRD, which is fundamental to successful treatment, animal welfare, and growth performance.
Revealing the impact of quasar luminosity on giant Ly α nebulae
Authors: Mackenzie Ruari , Pezzulli Gabriele , Cantalupo Sebastiano , Marino Raffaella A , Lilly Simon , Muzahid Sowgat , Matthee Jorryt , Schaye Joop , Wisotzki Lutz 
Published: October 2020

ABSTRACT
We present the results from a MUSE survey of twelve z ≃ 3.15 quasars, which were selected to be much fainter (20 &lt; iSDSS &lt; 23) than in previous studies of giant Ly α nebulae around the brightest quasars (16.6 &lt; iAB &lt; 18.7). We detect H i Ly α nebulae around 100 per cent of our target quasars, with emission extending to scales of at least 60 physical kpc, and up to 190 pkpc. We explore correlations between properties of the nebulae and their host quasars, with the goal of connecting variations in the properties of the illuminating QSO to the response in nebular emission. We show that the surface brightness profiles of the nebulae are similar to those of nebulae around bright quasars, but with a lower normalization. Our targeted quasars are on average 3.7 mag (≃30 times) fainter in UV continuum than our bright reference sample, and yet the nebulae around them are only 4.3 times fainter in mean Ly α surface brightness, measured between 20 and 50 pkpc. We find significant correlations between the surface brightness of the nebula and the luminosity of the quasar in both UV continuum and Ly α. The latter can be interpreted as evidence for a substantial contribution from unresolved inner parts of the nebulae to the narrow components seen in the Ly α lines of some of our faint quasars, possibly from the inner circumgalactic medium or from the host galaxy’s interstellar medium.
New Herbig–Haro objects and outflows in the Mon R1 association
Authors: Movsessian T A , Magakian T Yu , Dodonov S N 
Published: October 2020

ABSTRACT
We present the results of a narrow-band Hα and [S ii] imaging survey of the Mon R1 association performed with the 1-m Schmidt telescope at Byurakan Observatory. Our observations covered a 1° field near the centre of the association. As a result of this study, 20 new Herbig–Haro knots were discovered, some of which form collimated outflows. Among the most extended ones are HH 1203 and HH 1196, which have a length of 1 pc or even more. During the search for the probable sources of HH objects, several new nebulous stars were found. A list of all nebulous stellar objects in the Mon R1 area under study is presented, with detailed descriptions of the most interesting ones. The near-infrared data from the GLIMPSE360 and WISE surveys revealed several more objects related to Mon R1, some of which had optical counterparts, as well as helped to identify at least three probable H2 collimated flows from the deeply embedded pre-main-sequence objects. The probable members of Mon R1 were selected by their distances; their bolometric luminosities and extinctions were estimated. Among the outflow sources, three embedded objects with luminosities greater than 10 L⊙ were found. The mean distance to the Mon R1 complex is estimated as 715 pc.
AstroSat soft X-ray observations of the symbiotic recurrent nova V3890 Sgr during its 2019 outburst
Authors: Singh K P , Girish V , Pavana M , Ness Jan-Uwe , Anupama G C , Orio M 
Published: October 2020

ABSTRACT
Two long AstroSat Soft X-ray Telescope observations were taken of the third recorded outburst of the symbiotic recurrent nova V3890 Sgr. The first observing run, 8.1–9.9 d after the outburst, initially showed a stable intensity level with a hard X-ray spectrum that we attribute to shocks between the nova ejecta and the pre-existing stellar companion. On day 8.57, the first, weak, signs appeared of supersoft source (SSS) emission powered by residual burning on the surface of the white dwarf. The SSS emission was observed to be highly variable on time-scales of hours. After day 8.9, the SSS component was more stable and brighter. In the second observing run, on days 15.9–19.6 after the outburst, the SSS component was even brighter but still highly variable. The SSS emission was observed to fade significantly during days 16.8–17.8 followed by re-brightening. Meanwhile, the shock component was stable, leading to increase in hardness ratio during the period of fading. AstroSat and XMM–Newton observations have been used to study the spectral properties of V3890 Sgr to draw quantitative conclusions even if their drawback is model dependent. We used the xspec to fit spectral models of plasma emission, and the best fits are consistent with the elemental abundances being lower during the second observing run compared to the first for spectra ≥1 keV. The SSS emission is well fitted by non-local thermal equilibrium model atmosphere used for white dwarfs. The resulting spectral parameters, however, are subject to systematic uncertainties such as completeness of atomic data.
Wolf–Rayet stars in the Antennae unveiled by MUSE
Authors: Gómez-González V M A , Mayya Y D , Toalá J A , Arthur S J , Zaragoza-Cardiel J , Guerrero M A 
Published: October 2020

ABSTRACT
We present the analysis of archival Very Large Telescope (VLT) Multi-Unit Spectroscopic Explorer (MUSE) observations of the interacting galaxies NGC 4038/39 (a.k.a. the Antennae) at a distance of 18.1 Mpc. Up to 38 young star-forming complexes with evident contribution from Wolf–Rayet (WR) stars are unveiled. We use publicly available templates of Galactic WR stars in conjunction with available photometric extinction measurements to quantify and classify the WR population in each star-forming region, on the basis of its nearly Solar oxygen abundance. The total estimated number of WR stars in the Antennae is 4053 ± 84, of which there are 2021 ± 60 WNL and 2032 ± 59 WC-types. Our analysis suggests a global WC to WN-type ratio of 1.01 ± 0.04, which is consistent with the predictions of the single star evolutionary scenario in the most recent bpass stellar population synthesis models.
Identifying resonances of the Galactic bar in Gaia DR2: I. Clues from action space
Authors: Trick Wilma H , Fragkoudi Francesca , Hunt Jason A S , Mackereth J Ted , White Simon D M 
Published: October 2020

ABSTRACT
Action space synthesizes the orbital information of stars and is well suited to analyse the rich kinematic substructure of the disc in the second Gaia data release's radial velocity sample. We revisit the strong perturbation induced in the Milky Way disc by an m = 2 bar, using test particle simulations and the actions (JR, Lz, Jz) estimated in an axisymmetric potential. These make three useful diagnostics cleanly visible. (1) We use the well-known characteristic flip from outward to inward motion at the outer Lindblad resonance (OLR; l = +1, m = 2), which occurs along the axisymmetric resonance line (ARL) in (Lz, JR), to identify in the Gaia action data three candidates for the bar’s OLR and pattern speed Ωbar: 1.85Ω0, 1.20Ω0, and 1.63Ω0 (with ∼0.1Ω0 systematic uncertainty). The Gaia data is therefore consistent with both slow and fast bar models in the literature, but disagrees with recent measurements of ∼1.45Ω0. (2) For the first time, we demonstrate that bar resonances – especially the OLR – cause a gradient in vertical action 〈Jz〉 with Lz around the ARL via ‘Jz-sorting’ of stars. This could contribute to the observed coupling of 〈vR〉 and 〈|vz|〉 in the Galactic disc. (3) We confirm prior results that the behaviour of resonant orbits is well approximated by scattering and oscillation in (Lz, JR) along a slope ΔJR/ΔLz = l/m centred on the l:m ARL. Overall, we demonstrate that axisymmetrically estimated actions are a powerful diagnostic tool even in non-axisymmetric systems.
BIRTH of the COSMOS field: primordial and evolved density reconstructions during cosmic high noon
Authors: Ata Metin , Kitaura Francisco-Shu , Lee Khee-Gan , Lemaux Brian C , Kashino Daichi , Cucciati Olga , Hernández-Sánchez Mónica , Le Fèvre Oliver 
Published: October 2020

ABSTRACTThis work presents the first comprehensive study of structure formation at the peak epoch of cosmic star formation over 1.4 ≤ z ≤ 3.6 in the Cosmic Evolution Survey (COSMOS) field, including the most massive high-redshift galaxy proto-clusters at that era. We apply the extended COSMIC BIRTH algorithm to account for a multitracer and multisurvey Bayesian analysis at Lagrangian initial cosmic times. Combining the data of five different spectroscopic redshift surveys (zCOSMOS-deep, VUDS, MOSDEF, ZFIRE, and FMOS–COSMOS), we show that the corresponding unbiased primordial density fields can be inferred, if a proper survey completeness computation from the parent photometric catalogues, and a precise treatment of the non-linear and non-local evolution on the light-cone is taken into account, including (i) gravitational matter displacements, (ii) peculiar velocities, and (iii) galaxy bias. The reconstructions reveal a holistic view on the known proto-clusters in the COSMOS field and the growth of the cosmic web towards lower redshifts. The inferred distant dark matter density fields concurrently with other probes like tomographic reconstructions of the intergalactic medium will explore the interplay of gas and dark matter and are ideally suited to study structure formation at high redshifts in the light of upcoming deep surveys.
The effects of star formation history in the SFR–M* relation of H ii galaxies
Authors: Lopes Amanda R , Telles Eduardo , Melnick Jorge 
Published: October 2020

ABSTRACT
We discuss the implications of assuming different star formation histories (SFH) in the relation between star formation rate (SFR) and mass derived by the spectral energy distribution fitting (SED). Our analysis focuses on a sample of H ii galaxies, dwarf starburst galaxies spectroscopically selected through their strong narrow emission lines in SDSS DR13 at z &lt; 0.4, cross-matched with photometric catalogues from GALEX, SDSS, UKIDSS, and WISE. We modelled and fitted the SEDs with the code CIGALE adopting different descriptions of SFH. By adding information from different independent studies, we find that H ii galaxies are best described by episodic SFHs including an old (10 Gyr), an intermediate age (100−1000 Myr) and a recent population with ages &lt; 10 Myr. H ii galaxies agree with the SFR−M* relation from local star-forming galaxies, and only lie above such relation when the current SFR is adopted as opposed to the average over the entire SFH. The SFR−M* demonstrated not to be a good tool to provide additional information about the SFH of H ii galaxies, as different SFH present a similar behaviour with a spread of &lt;0.1 dex.
Physical explanation for the galaxy distribution on the (λR, ε) and (V/σ, ε) diagrams or for the limit on orbital anisotropy
Authors: Wang Bitao , Cappellari Michele , Peng Yingjie 
Published: October 2020

ABSTRACT
In the (λR, ε) and (V/σ, ε) diagrams for characterizing dynamical states, the fast-rotator galaxies (both early type and spirals) are distributed within a well-defined leaf-shaped envelope. This was explained as due to an upper limit to the orbital anisotropy increasing with galaxy intrinsic flattening. However, a physical explanation for this empirical trend was missing. Here, we construct Jeans Anisotropic Models (JAM), with either cylindrically or spherically aligned velocity ellipsoid (two extreme assumptions), and each with either spatially constant or variable anisotropy. We use JAM to build mock samples of axisymmetric galaxies, assuming on average an oblate shape for the velocity ellipsoid (as required to reproduce the rotation of real galaxies), and limiting the radial anisotropy β to the range allowed by physical solutions. We find that all four mock samples naturally predict the observed galaxy distribution on the (λR, ε) and (V/σ, ε) diagrams, without further assumptions. Given the similarity of the results from quite different models, we conclude that the empirical anisotropy upper limit in real galaxies, and the corresponding observed distributions in the (λR, ε) and (V/σ, ε) diagrams, are due to the lack of physical axisymmetric equilibrium solutions at high β anisotropy when the velocity ellipsoid is close to oblate.
Judicial-ENE and the ‘New Normal’
Authors: Islam Carl 
Published: October 2020

Abstract
The author’s premise is that in claims allocated to the multi-track, Judicial-Early Neutral Evaluation ('JENE') is the new normal. He discusses: the rationale; jurisdiction; and powers of the court to order JENE; its benefits; and the procedure. He concludes that, except where a claim involves the interests of minors and unborn beneficiaries, use of this case management tool is likely to become increasingly routine at the first case management conference where, for example, one party has proposed JENE, and the other has refused consent because he prefers mediation. Whereas mediation requires consent, JENE does not, and the court has the power at the first Case Management Conference to order a stay during which the parties must: (i) take stock and (ii) each carry out a reality check, i.e. before substantial costs are incurred in preparing for trial. Therefore, in an appropriate case, where a binary outcome on liability can open the door to settlement in relation to quantum, relief, and costs, JENE should be considered.