bluuebunny/crossref_metadata_2025_split huggingface dataset:
Competitiveness, Specialization, and Structural Shifts in India's Honey Exports: An Analysis of Global Market Dynamics From 2003 to 2022
Authors: Powrel Pronab Jyoti , Mishra Snehal 
Published: December 2024

ABSTRACTThis paper examines the dynamics, competitiveness, specialization, and structural changes in India's honey exports from 2003 to 2022 utilizing trade data under HS code 04090000. This paper analyzes Indian honey export under different indices, including the revealed comparative advantage (RCA), revealed symmetric comparative advantage (RSCA), comparative export performance (CEP), trade balance index (TBI), and Grubel–Lloyd index (GLI). A detailed analysis reveals significant export growth, with a compound annual growth rate (CAGR) of 11.72% over the past decade, driven primarily by the US market, which accounted for 80% of India's honey exports in 2022. However, high export instability was noted in the US market, while GCC and SAARC countries exhibited more stable demand. The research also assesses market loyalty using Markov chain analysis, highlighting the US as the most stable export destination. Structural changes in India's honey export markets were identified, with the Gulf countries and Africa emerging as key markets following the European Union's 2010 ban on Indian honey. Despite competitive pressure from major honey‐exporting nations like New Zealand and Argentina, India's strong comparative advantage and specialized export focus position it favorably in the global market. The paper tries to highlight the need for strategic diversification of export markets and expansion of honey production to sustain India's growth in the honey export sector.
Quantification of Vactosertib an Inhibitor of TGFBR1 by LC–MS/MS in Rat Plasma and Its Pharmacokinetic Profiling
Authors: Boggavarapu Rajesh Kumar , Chimakurthy Jithendra , Konidala Sathish Kumar 
Published: December 2024

ABSTRACTVactosertib, an inhibitor of transforming growth factor β‐receptor type‐1 (TGFBR1) effective in preventing tumor cell proliferation, is approved for treating various cancers by FDA. The literature revealed that no LC–MS/MS method was reported for the quantification of vactosertib. To develop a validated LC–MS/MS method for the quantification of vactosertib in rat plasma, vactosertib and cabozantinib (internal standard [IS]) were detected using Waters LC–MS/MS system in MRM positive ionization mode, with a mixture of 0.2% formic acid and acetonitrile (70:30, v/v) on an Agilent XDB C18 (50 × 2.1 mm, 5 μm) column at a flow rate of 0.8 mL/min. The method was validated in accordance with M10 bioanalytical method validation USFDA guidelines and applied for the determination of pharmacokinetic parameters in rat plasma. The analytes were detected at m/z 400.23 → 289.19 and m/z 502.13 → 323.07 for vactosertib, and IS, respectively. The method demonstrated a sensitivity of 1.0 ng/mL, linearity ranging from 1.0 to 1000.0 ng/mL, an r2 of 0.999, accuracy ranged between 91.60% and 100.70%, and the drug was found to be stable across all freeze–thaw cycles. The results indicated that the method was selective, accurate, and validated for quantification of vactosertib in biological fluids and pharmacokinetic profiling of vactosertib.
Achieving Supply Chain Sustainable Development Within the Framework of Carbon Neutrality Scenario—A Bibliometric Analysis
Authors: Huang Rui , Luo Xizi 
Published: December 2024

ABSTRACTGreenhouse gas emissions in supply chains present significant challenges for achieving carbon neutrality because of their complexity and uncertainty. This study employs the Web of Science database for a quantitative analysis of the evolution, status, cooperation patterns, and future research on carbon neutrality in supply chains, using knowledge graphs, visualization, and cooperation network analysis. The study aims to contribute to carbon neutrality in supply chains for environmental and social benefits. The key findings are as follows: (1) Since 2020, there has been a sharp rise in publications, and attention to carbon neutrality in supply chains is expected to continue increasing. (2) China leads in publication volume and is a central contributor, though a “North–South gap” in collaboration persists between developed and developing countries. (3) Keyword co‐occurrence analysis indicates that research on challenges, technologies, and methods in this area is relatively advanced. (4) Burst analysis identifies “green logistics” and “electric vehicles” as critical future research areas. This study offers policy guidance to support decision‐making for achieving sustainable economic and environmental development in supply chains.
Immediate Percutaneous Treatment of Aortic Root Rupture During Transcatheter Aortic Valve Implantation
Authors: Muntané‐Carol Guillem , Romaguera Rafael , Teruel Luis , Gómez‐Hospital Joan A. 
Published: December 2024

ABSTRACTThis case shows the combination of two percutaneous techniques to treat an aortic root rupture during transcatheter aortic valve implantation. The patient was discharged at home and no cardiovascular events occurred at 12 months of follow up.
Successful Treatment of Severe Tuberculosis With Contezolid Add‐On Regimen in a Patient Complicated With Acute Thrombocytopenia: A Case Report
Authors: Zhou Liuqing , Wang Yimin , Zhou Jixue 
Published: December 2024

ABSTRACTPolypharmacy in managing severe tuberculosis patients usually poses a risk of adverse drug reactions. Contezolid is a new oxazolidinone antibiotic showing good in vitro and in vivo activity against Mycobacterium tuberculosis. Contezolid add‐on regimen shows promising efficacy and safety results in managing severe tuberculosis patients complicated with acute thrombocytopenia.
End Binding Proteins: Drivers of Cancer Progression
Authors: Sasankan Dhakshmi , Mohan Renu 
Published: December 2024

ABSTRACTCancer, a complex and heterogeneous disease, continues to be a major global health concern. Despite advancements in diagnostics and therapeutics, the aggressive nature of certain cancers remain a significant challenge, necessitating a deeper understanding of the underlying molecular mechanisms driving their severity and progression. Cancer severity and progression depend on cellular properties such as cell migration, cell division, cell shape changes, and intracellular transport, all of which are driven by dynamic cellular microtubules. Dynamic properties of microtubules, in turn, are regulated by an array of proteins that influence their stability and growth. Among these regulators, End Binding (EB) proteins stand out as critical orchestrators of microtubule dynamics at their growing plus ends. Beyond their fundamental role in normal cellular functions, recent research has uncovered compelling evidence linking EB proteins to the pathogenesis of various diseases, including cancer progression. As the field of cancer research advances, the clinical implication of EB proteins role in cancer severity and aggressiveness become increasingly evident. This review aims to comprehensively explore the role of microtubule‐associated EB proteins in influencing the severity and aggressiveness of cancer. We also discuss the potential significance of EB as a clinical biomarker for cancer diagnosis and prognosis and as a target for therapeutic intervention.
Prenatal Origins of Obstructive Airway Disease: Starting on the Wrong Trajectory?
Authors: Wang Kimberley C.W. , James Alan L. , Donovan Graham M. , Noble Peter B. 
Published: December 2024

Abstract

From the results of well‐performed population health studies, we now have excellent data demonstrating that deficits in adult lung function may be present early in life, possibly as a result of developmental disorders, incurring a lifelong risk of obstructive airway diseases such as asthma and chronic obstructive pulmonary disease. Suboptimal fetal development results in intrauterine growth restriction and low birth weight at term (an outcome distinct from preterm complications), which are associated with subsequent obstructive disease. Numerous prenatal exposures and disorders compromise fetal development and these are summarized herein. Various physiological, structural, and mechanical abnormalities may result from prenatal disruption, including changes to airway smooth muscle structure–function, goblet cell biology, airway stiffness, geometry of the bronchial tree, lung parenchymal structure and mechanics, respiratory skeletal muscle contraction, and pulmonary inflammation. The literature therefore supports the need for early life intervention to prevent or correct growth defects, which may include simple nutritional or antioxidant therapy. © 2024 American Physiological Society.
Compr Physiol
14:5729‐5762, 2024.
Characterization of cool‐ and warm‐season turfgrass host suitability to annual bluegrass weevil (Listronotus maculicollis, Kirby)
Authors: Simard Audrey , McGraw Benjamin A. 
Published: December 2024

AbstractThe annual bluegrass weevil, Listronotus maculicollis Kirby, is considered the most destructive insect pest of short‐mown turfgrasses in northeastern North America. Poa annua L. is the preferred host plant, though the weevil can develop in other cool‐season (C3) turfgrasses such as bentgrasses (Agrostis spp. L.) and perennial ryegrass (Lolium perenne L.). Recently, damaging populations have been reported in midwestern and southeastern United States, where cool‐ and warm‐season (C4) turfgrasses are grown. However, it is unknown whether L. maculicollis can establish and develop within common warm‐season turfgrasses such as zoysiagrasses (Zoysia matrella L.) and hybrid bermudagrasses (Cynodon dactylon Pers. × transvaalensis Davy). Larvae reared on Agrostis stolonifera ‘Penncross’, an older cultivar, experienced a significant reduction in survivorship and longer development periods compared to a newer cultivar (Penn‐A4) and P. annua. Agrostis stolonifera ‘Penncross’ possessed significantly greater quantities of carotenoids and flavonoid content, which may explain differences in host suitability among C3 turfgrasses. No larvae were recovered from C4 hosts in no‐choice ovipositional assays, suggesting Z. matrella and C. dactylon × transvaalensis are nonviable hosts of L. maculicollis. Further investigation into the morphological and physiological defense mechanisms in Z. matrella and C. dactylon × transvaalensis may broaden our understanding of tolerance mechanisms not observed in C3 cool‐season turfgrasses and provide guidance for future breeding efforts.
Comparative Analysis of Mitogenomes in Leafhopper Tribe Deltocephalini (Hemiptera: Cicadellidae: Deltocephalinae): Structural Conservatism and Phylogeny
Authors: Xie Bingqing , Zhang Xinyi , Zhang Yongxia , Dietrich Christopher H. , Duan Yani 
Published: December 2024

ABSTRACTPrevious studies on the gene order and composition of leafhopper mitochondrial genomes have revealed a high level of conservation in overall genome structure. Some members of Deltocephalinae, the largest subfamily, exhibit tRNA gene rearrangements; however, few mitogenomes have been sequenced in this group and the degree of structural variation within tribes remains unclear. In this study, we sequenced the complete mitogenomes of 14 species belonging to four genera of tribe Deltocephalini from China and compared them with the two previously reported mitogenomes for this tribe. The studied mitogenomes showed a high degree of similarity to most other leafhopper mitogenomes in overall structure, mostly varying in the total length (14,961–15,416 bp) and number of non‐coding A + T‐rich regions. Gene size, order, arrangement, base composition, codon usage, and secondary structure of tRNAs in the newly sequenced mitogenomes were highly conserved in Deltocephalini, and variations in start/stop codon usage and tRNA secondary structure mostly matched those of other leafhoppers. Phylogenetic analysis of different combinations of protein‐coding and ribosomal genes using maximum likelihood and Bayesian inference under different models using either amino acid or nucleotide sequences were generally consistent and agreed with the previous nuclear and partial mitochondrial gene sequence data, indicating that complete mitochondrial genomes are phylogenetically informative at different levels of divergence within Deltocephalini and among different leafhoppers species. In addition to Deltocephalini, Deltocephalinae included members of Athysanini and Opsiini formed monophyletic groups. Maximum likelihood and Bayesian inference analyses consistently grouped Graminella nigrinota with Paralimnini, rendering Deltocephalini polyphyletic. The topology consistently divided Deltocephalini into two major branches, with Alobaldia tobae and Polyamia penistenuis forming a well‐supported sister group to the remaining species of the tribe.
Observational study for multiparametric assessment of cardiac congestion in outpatient worsening heart failure (EVOLUTION)
Authors: Cotter Gad , Davison Beth , Janiak Philip , Edwards Christopher , Novosadova Maria , Takagi Koji , Ozoux Marie‐Laure , Lawson Francesca , Hayrapetyan Hamlet , Sisakian Hamayak , Ter‐Grigoryan Victor R. , Peoc'h Katell , Raynor Alexandre , Bruzeau Paul , Nguyen Alexis , Mebazaa Alexandre 
Published: December 2024

AbstractAimsWe sought to characterize the clinical course of patients following worsening heart failure (WHF) treated in an outpatient setting and to identify factors associated with a poor response to standard of care with loop diuretics.Methods and resultsBetween September 2022 and March 2023, 44 eligible patients (mean age 66.3 years, 84% male) with ejection fraction <50% and with WHF symptoms in the preceding week treated in an outpatient setting were enrolled. Patients were assessed weekly over 4 weeks following the WHF episode. At week 4, responses to fluid expansion and furosemide administration were assessed in 39 patients to unmask persistent subclinical congestion. Patients were on stable doses of guideline‐directed medical therapy (GDMT) with a mean daily furosemide dose of 47.4 mg. Patient‐reported and physician‐assessed symptoms and quality of life improved over the 4 weeks. At 1 h following 1 L Ringer solution infused over 2 h, the median (interquartile range) urine volume and urine sodium excreted over 3 h were 300 (200.0–500.0) ml and 39.6 (12.4–63.0) mEq, respectively. Receiver‐operating characteristic curves suggest that cystatin C >1.2 ng/ml, N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) >1500 pg/ml, and high‐sensitivity troponin T >20 pg/ml represent good predictors of non‐response to a fluid challenge (diuresis, natriuresis, and rales) following an outpatient WHF, with having all three markers associated with the worst response.ConclusionPatients with high levels of troponin, or NT‐proBNP, or cystatin C who develop WHF despite being treated with a loop diuretic, need novel therapies for WHF.
Professional Digital Counselling for Eating Disorders in Germany: Results of the DigiBEssst Project Survey on the Perspectives and Experiences of Health Professionals, Individuals With Eating Disorders, and Carers
Authors: Hofer Anna , Borse Sigrid , Hasenöhrl Cäcilia , Harrach Kathrin , Ehrlich Stefan , Schnebel Andreas , Wunderer Eva 
Published: December 2024

ABSTRACTObjectiveThe research project DigiBEssst examines existing digital counselling services for individuals with eating disorders (ED) and carers in Germany. It highlights their experiences with digital counselling as well as those of the expert counsellors involved, aiming to derive quality criteria for digital counselling in ED.MethodA mixed‐methods design was adopted. Analysing the websites of 181 professional counselling centers, the research team identified 86 counselling centers for ED that offered online counselling. Initially, 29 centres participated in an online survey. Subsequently, in‐depth, semi‐structured interviews were conducted with professionals (n = 15), individuals with ED (n = 13), and carers (n = 10). The data were analysed using descriptive statistics and structured content analysis.ResultsLess than half of the German counselling facilities offered online counselling. The participants emphasised the need for a specific concept, counsellors' profound expertise in ED and online counselling, sustainable funding, sufficient personnel and time resources, and secure platforms to ensure data protection and quality management. Access to professional services requires informative, user‐friendly websites, and social media presence.ConclusionsThe identified prerequisites and quality criteria for professional online counselling developed in this project can provide recommendations for the conceptualisation of digital counselling services.
Spray‐Dried Wheat Gluten Protein Hydrolysate Microcapsules: Physicochemical Properties, Retention of Antioxidant Capability, and Release Behavior Under Simulated Gastrointestinal Digestion Conditions
Authors: GanjiVtan Benyamin , Hosseini Ghaboos Seyyed Hossein , Sadeghi Mahoonak Alireza , Shahi Taher , Farzin Neda 
Published: December 2024

ABSTRACTWheat gluten is a by‐product of the wheat starch industry, rich in bioactive peptides. Spray drying is an effective method for improving the stability of bioactive compounds. So, the aim of this study was to produce gluten hydrolysate by different proteases (alcalase, pancreatin, and trypsin) at different times (40–200 min). The hydrolysate with the strongest antioxidant potential (produced by pancreatin after 200 min of hydrolysis) was encapsulated by spray drying. The effect of wall material's type (maltodextrin, potato starch, and their combination at different ratios) on the encapsulation efficiency, physicochemical properties (moisture content, solubility, water activity, tapped and bulk density, and hygroscopicity), release behavior under simulated gastrointestinal digestion conditions, and morphology of microcapsules were evaluated. The microcapsules produced by maltodextrin and potato starch at a 30:70 ratio possessed the highest water activity (0.36), encapsulation efficiency (85.79%), and moisture content (8.2%). An increase in maltodextrin concentration increased the solubility, bulk, and tapped density. SEM images showed that microparticles were spherical with wrinkled surfaces. The microcapsules showed higher stability than free gluten hydrolysate. The combination of maltodextrin and potato starch at a 30:70 ratio could control the release of gluten hydrolysate under simulated gastrointestinal conditions. As a result, the use of maltodextrin and potato starch carriers at a 30:70 ratio in spray drying could effectively protect the bioactive properties of gluten hydrolysate and control its release.
Edible Coating Based on Alginate Nanoparticles Containing Menthol and Zataria multiflora Essential Oil: Effect on the Shelf Life of Chicken Thigh in the Refrigerator
Authors: Ranjbar Ali , Osanloo Mahmoud , Safari Mojdeh , Eskandari Zahra , Safari Ehsan , Nematollahi Amene 
Published: December 2024

ABSTRACTChicken thigh is a popular and widely consumed meat product. However, its high moisture content and susceptibility to microbial spoilage limit its shelf life. To address this issue, we investigated the efficacy of an edible coating based on alginate nanoparticles (AlgNPs) containing menthol, Zataria multiflora essential oil (EO), or their combination for extending the shelf life of chicken thigh. The nanoparticles were prepared through ionic gelation methods; their particle size was obtained as 87–205 nm with PDI values of < 0.3 and SPAN values of < 1. The AlgNPs containing both menthol and the EO showed the most potent antimicrobial activity (the lowest counts of pseudomonas, aerobic mesophilic, and yeast‐mold), during cold storage. This coating treatment showed also the highest antioxidant activities, with the lowest thiobarbituric acid reactive substances (TBARS), pH and total volatile basic nitrogen (TVBN) values. Moreover, this coating significantly (p < 0.05) showed the highest sensory quality of chicken thighs, as evidenced by the higher sensory scores for texture, odor, color, and overall acceptability. Therefore, the edible coating based on AlgNPs containing menthol and Z. multiflora EO is an effective and promising approach for extending the shelf life of chicken thighs.
Extreme Temperature Events in Kazakhstan and Their Impacts on Public Health and Energy Demand
Authors: Broomandi Parya , Satyanaga Alfrendo , Bagheri Mehdi , Hadei Mostafa , Galán‐Madruga David , Fard Ali Mozhdehi , Roshani Adib , Fathian Aram , Nourian Amir , Leuchner Michael , Reicherter Klaus , Hamidi Mehdi , Kumar Prashant , Kim Jong Ryeol 
Published: December 2024

AbstractExtreme temperature events such as heatwaves are becoming increasingly severe and frequent because of climate change, posing significant challenges to public health and energy infrastructure. This study explores the impacts of extreme temperature events leading to heat‐/cold waves on public health and energy consumption in Kazakhstan from 1959 to 2021. The most striking trends in heatwave‐related indices emerge in the western and southwestern regions. Conversely, despite heightened coldwave intensity, a decline is noted in their frequency and number. The impact of heatwaves on various health conditions, notably consistent and statistically significant rises in all‐cause and cardiovascular mortalities, is observed. Shifts in energy demand are also unveiled with a noticeable spike in cooling‐degree days and a reduction in heating‐degree days. The mean total energy consumption stood at 552 kWh across the country with an average annual energy generation of ≈8.76 kWh. To gauge the environmental implications, the mean CO2 emissions are estimated at 464 kg per kWh for both heating and cooling purposes. With climate change set to escalate heatwaves, the need for comprehensive health planning is underscored to mitigate their adverse health impacts. Furthermore, transitioning from fossil fuels to green energy sources is crucial to reduce the environmental footprint.
Dental Health Services Victoria health promotion messages for oral health: A modified Delphi study
Authors: Pham Shelley , Evans Kelli , Patel Kishita , Gallagher Fiona , Nguyen Tan Minh 
Published: December 2024

AbstractIssue AddressedThe 2022 Oral health messages for Australia were reviewed, revised and published in 2023. This study adapted these messages from a value‐based communication perspective to support Dental Health Services Victoria population health programs and resources.MethodsA modified Delphi RAND/UCLA appropriateness method was adopted. An expert panel was convened, which included public oral health professionals and health promotion practitioners at Dental Health Services Victoria. The 2022 Oral health messages for Australia were reviewed and adapted to ensure consistency and relevance to consumers and health professionals. Once there was general agreement by the expert panel on the Dental Health Services Victoria health promotion messages for oral health, a follow‐up anonymous survey was sent to the expert panel to rate their level of agreement. Additionally, the messages were evaluated for ease of readability with an anonymous survey of consumers.ResultsA total of 23 participants were invited on the expert panel, of which 16 agreed to participate. Considerations were made to reflect a broad perspective across disciplines in public oral health professionals encompassing expertise in policy, advocacy and health promotion. Broadly, there was agreement to adapt all of the 2022 Oral health messages for Australia. The level of agreement by the expert panel ranged from 73% to 100%. Amongst 13 consumer respondents to the survey, the level of agreement ranged from 62% to 100%.ConclusionThere was sufficient rationale to adapt the 2022 Oral health messages for Australia for the Victorian context by using a value‐based messaging approach.So What?This study demonstrated that adaption was necessary to the 2022 Oral health messages for Australia, potentially leading to more impactful health promotion messages for oral health in Victoria.