bluuebunny/crossref_metadata_2025_split huggingface dataset:
Competitive intelligence in hospitality and tourism: a perspective article
Authors: Köseoglu Mehmet Ali , Morvillo Alfonso , Altin Mehmet , De Martino Marcella , Okumus Fevzi 
Published: November 2019

Purpose
This study aims to critically review competitive intelligence (CI) research and offer suggestions for future research in the hospitality and tourism (HT) field.

Design/methodology/approach
The study reviews and synthetizes current CI research in the HT field.

Findings
The study findings suggest that CI research in HT is at an embryonic level, as researchers have not used the same terminology on what CI is, how CI is implemented and what should be included in the CI framework. Hence, researchers should address the link between operation and CI practices. Also, new studies discussing business espionage and ethics in CI practices are needed because the related studies are rare.

Practical implications
The study offers specific theoretical and practical implications for CI research.

Originality/value
This study provides a perspective on future developments of CI research in the HT field.
The entrepreneurial ecosystem quality for sustainable franchising
Authors: Mutumba Abbey , Ngoma Mohammad , Munene John C. , Ntayi Joseph Mpeera 
Published: November 2019

PurposeThe purpose of this paper is to establish the mediation effects of public–private–partnership (PPP) on the association between complementary entrepreneurial networking and the entrepreneurial ecosystem quality for sustainable franchising.Design/methodology/approachA structured questionnaire was used to collect this study’s qualitative data from a study population of sub-franchisor organizations in Uganda. Statistical techniques were used to analyze the data.FindingsPart of the authorized distributors’ mutually beneficial networking is directly connected to multi-actor networks that continuously simplify their local access to affordable franchise financing, mentors and supportive leaders. Also, the same association is mediated through PPP supported franchise-business information and widely appealing awards to be won.Research limitations/implicationsOne of the areas for further study is a related study on the moderating effects of the PPP support in another developing country, which is clarified in this study.Originality/valueThe complexity theory has provided an explanation of the entrepreneurial ecosystem quality for sustainable franchising across the rural and urban markets in an African country.
Japanese Dermatological Association Guidelines: Outlines of guidelines for cutaneous melanoma 2019
Authors: Nakamura Yasuhiro , Asai Jun , Igaki Hiroshi , Inozume Takashi , Namikawa Kenjiro , Hayashi Ayato , Fukushima Satoshi , Fujimura Taku , Ito Takamichi , Imafuku Keisuke , Tanaka Ryota , Teramoto Yukiko , Minagawa Akane , Miyagawa Takuya , Miyashita Azusa , Wada Makoto , Koga Hiroshi , Sugaya Makoto 
Published: November 2019

AbstractWith consideration of the ongoing developments in treatment options for cutaneous melanoma, the Japanese Skin Cancer Society published the first guidelines for cutaneous melanoma in 2007 and later revised them in 2015. Here, we report on an English version of the 2019 Japanese Melanoma Guidelines. In this latest edition, all processes were carried out according to the Grading of Recommendations, Assessment, Development and Evaluation system. A comprehensive published work search, systematic review and determination of recommendations in each clinical question were performed by a multidisciplinary expert panel consisting of dermatologists, a plastic and reconstructive surgeon, and a radiation oncologist. The advent of novel agents, such as immune checkpoint inhibitors and molecular‐targeted agents, has drastically changed the nature of treatment for adjuvant and advanced‐stage diseases among melanoma patients worldwide. Additionally, recent reports of clinical trials regarding surgical procedures and a better understanding of molecular biology and tumor immunology in clinical types of melanoma have had an impact on clinical practise. Based on these viewpoints, eight relevant clinical questions were raised in this report that aim to help clinicians select the appropriate therapeutic approach.
Working transgenerationally: a clinical discussion on family dynamics and treatment
Authors: Lee Wai‐Yung 
Published: November 2019

Building on Lieberman’sTransgenerational theory(1979), which posited that many inexplicable family problems could be traced to unresolved conflicts arising from clashes between cultural differences across generations, forty multi‐generation families that have been treated with either a child, an adult, or a member from the older generation as symptom bearers were reviewed in this project. This paper is a discussion of the findings obtained from exploring these presenting symptoms from the perspective of transgenerational dynamics, and a presentation of a treatment approach in working transgenerationally. In addition to family histories, we also focused in this work on the importance of working with problematic interpersonal patterns across generations in order to negotiate a more satisfactory and developmentally appropriate boundary between subsystems.Practitioner pointsAnalysis of clinical data with Chinese families shows that many individual mental health problems can reflect unresolved conflict in transgenerational relationshipsTransgenerational theory is useful in helping us understand the link between generationsAlong with structural family therapy theory this enables members of multi‐generations to negotiate a developmentally appropriate pattern between subsystemsUsing biofeedback in a family assessment protocol to elicit children’s responses to parental conflict helps link repeated patterns transmitted transgenerationally
Against a descriptive turn
Authors: Gane Nicholas 
Published: November 2019

AbstractWhile description is a valuable aspect of meaningful sociological work, this paper takes issue with Mike Savage’s argument that the social sciences, and sociology in particular, should seek to prioritize description over practices of explanation and analysis, and attention to questions of causality. The aim of this paper is not to take issue with descriptive forms of sociology in themselves, but to argue that the answer to the problems identified by Savage and Burrows in their landmark paper “The Coming Crisis of Empirical Sociology” is not to follow commercial forms of research by prioritizing practices of description and classification at the cost of asking fundamental questions about the “why?” and the “how?” of social life and politics. Rather, this paper argues that it is imperative that sociology does not simply describe inequalities of different types, but questions, explains, and analyses the structures and mechanisms through which they are created, reproduced, and sustained. The argument will be developed in three stages. First, this paper will restate the main points of Savage’s call for descriptive sociology; second, it will address his critique of “epochalist thinking” and subsequent opposition to the idea of neoliberalism; and third, it will respond to his use of Thomas Piketty’s work as a model for developing sociological descriptions of class and inequality.
Argentinean Puna Plants with In Vitro Antioxidant and Anti‐Inflammatory Activities as a Potential Nutraceutical
Authors: Torres‐Carro Romina , Ana Yamile , Rojas‐Márquez Jorge David , Stempin Cinthia Carolina , Zampini Iris Catiana , Isla María Inés , Alberto María Rosa 
Published: November 2019

AbstractParastrephia lucida (Compositae), Tessaria absinthioides (Compositae), and Ephedra multiflora (Ephedraceae), three plant species from the Argentinean Puna (3600 m.a.s.l.) were selected for their anti‐inflammatory and antioxidant properties to prepare mixtures to evaluate their use as nutraceuticals. Seven binary and ternary herbal mixtures made of ethanol 20% extracts of the selected plant species were prepared (Mixtures A to G), and they were analyzed for their effect on proinflammatory enzymes and their antioxidant activity in two cellular systems and in cell free systems. Toxicity tests were also carried out, and they were analyzed by high‐performance liquid chromatography with a diode‐array detector (HPLC‐DAD) to quantify chemical markers. Mix A (equal parts of the three selected plant species) showed an important inhibitory capacity of different proinflammatory enzymes. Its potency on COX‐2 was also higher than that of ibuprofen. Mix A and Mix G (P. lucida and T. absinthioides 1:1) showed a high antioxidant capacity in cellular and in cell‐free systems. Toxicity assays further demonstrated their safety. This work shows the potential use of herbal mixtures made of medicinal plant species from the Argentinean Puna as nutraceutical or dietary supplements with antioxidant and anti‐inflammatory activities.Practical ApplicationP. lucida, T. absinthioides, and E. multiflora are three plant species that are commonly used by Argentinean Puna inhabitants with medicinal purposes. Their proven safety, their antioxidant activity as well as their capacity to inhibit different proinflammatory enzymes make them attractive candidates to be used in combination as part of a dietary supplement aimed to prevent or palliate gastrointestinal and systemic inflammatory diseases. The use of native plant species as an alternative to more common and commercial plant species would have a positive impact on local communities’ economies.
Rheumatic heart disease in pregnancy: Profile of women admitted to a Western Australian tertiary obstetric hospital
Authors: Ongzalima Chris O. , Greenland Melanie , Vaughan Geraldine , Ng Andre , Fitz‐Gerald Jordan A. , Sanfilippo Frank M. , Dickinson Jan E. , Hung Joe , Katzenellenbogen Judith M. 
Published: November 2019

This retrospective study assessed maternal and perinatal outcomes for women with rheumatic heart disease (RHD) admitted to the largest tertiary obstetric hospital in Western Australia from 2009 to 2016. Of 54 women identified, 75.9% were Indigenous, 59.3% lived in rural areas and 40.7% had severe RHD. Heart failure developed in 10% who gave birth. Indigenous women were younger, had higher gravidity (P = 0.0305), were more likely to receive secondary prophylaxis (P = 0.0041) and have sub‐optimal antenatal clinic attendance (P = 0.0078). There were no maternal deaths and two perinatal deaths (4.0%), reflecting vigilance in the obstetric management of women with RHD in Western Australia.
Erythrocyte transfusions increased the risk of elevated serum ferritin in very low birthweight infants and were associated with altered longitudinal growth
Authors: Alm Stina , Stoltz Sjöström Elisabeth , Nilsson Sommar Johan , Domellöf Magnus 
Published: November 2019

AbstractAimThere has been a lack of population‐based longitudinal data on serum ferritin in very low birthweight (VLBW) infants during hospitalisation. Our aim was to fill this gap in the knowledge and investigate risk factors for elevated serum ferritin and associations between erythrocyte transfusions and longitudinal growth.MethodsWe retrospectively reviewed longitudinal data on 126 VLBW infants treated at Umeå University Hospital, Sweden, between 2010 and 2013.ResultsThe infants' mean gestational age and birthweight were 26.9 weeks and 899 g. Most (91%) received erythrocyte transfusions, and the majority had multiple erythrocyte transfusions. There was a significant correlation between serum ferritin and the volume of transfusions. Almost two‐thirds had at least one serum ferritin measurement of more than 350 µg/L, indicating iron overload. In those with complete anthropometric data (n = 78), there was no significant effect of serum ferritin concentrations in relation to longitudinal growth, but there was a positive association between the erythrocyte transfusion dose and longitudinal growth in VLBW infants born before 25 weeks.ConclusionThis is the first population‐based study to investigate longitudinal data on serum ferritin in VLBW infants during hospitalisation. The unexpected positive finding in the subgroup born at less than 25 weeks needs further research with a larger cohort.
Cost‐effectiveness of long‐acting insulin analogues vs intermediate/long‐acting human insulin for type 1 diabetes: A population‐based cohort followed over 10 years
Authors: Lee Tsung‐Ying , Kuo Shihchen , Yang Chen‐Yi , Ou Huang‐Tz 
Published: November 2019

AimsThis study assessed the cost‐effectiveness of long‐acting insulin analogues (LAIAs) vs intermediate/long‐acting human insulin (ILAHI) for patients with type 1 diabetes (T1D) in real‐world clinical practice.MethodsIndividual‐level analyses were conducted within a longitudinal population‐based cohort of 540 propensity score‐matched T1D patients (LAIAs, n = 270; ILAHI, n = 270) with over 10 years of follow‐up using Taiwan's National Health Insurance Research Database, 2004–2013, from third‐party payer and healthcare sector perspectives. The study outcomes included the number needed to treat (NNT) to prevent one case of clinical events (eg, hypoglycaemia, diabetes‐related complications), medical costs, and cost per case of events prevented. Cost estimates are presented in 2013 British pounds (GBP, £).ResultsThe NNTs using LAIAs vs ILAHI to avoid one case of hypoglycaemia requiring medical assistance, outpatient hypoglycaemia and any diabetes‐related complications were 12, 9 and 10 for mean follow‐up periods of 5.84, 6.02 and 3.62 years, respectively. From third‐party payer and healthcare sector perspectives, using LAIAs instead of ILAHI saved GBP6924‐GBP7116 per case of hypoglycaemia requiring medical assistance prevented, GBP5346‐GBP5508 per case of outpatient hypoglycaemia prevented, and GBP3570‐GBP3680 per case of any diabetes‐related complications prevented. Sensitivity analyses considering sampling uncertainty showed that using LAIAs over ILAHI yields at least a 76% probability of cost‐saving for avoiding one case of hypoglycaemia requiring medical assistance, outpatient hypoglycaemia or any diabetes‐related complications.ConclusionsThis real‐world evidence reveals that compared with ILAHI, the greater pharmaceutical costs associated with LAIAs for patients with T1D could be substantially offset by savings from averted hypoglycaemia or diabetes‐related complications.
Acute caffeine intake increases muscle oxygen saturation during a maximal incremental exercise test
Authors: Ruíz‐Moreno Carlos , Lara Beatriz , Brito de Souza Diego , Gutiérrez‐Hellín Jorge , Romero‐Moraleda Blanca , Cuéllar‐Rayo Ángel , Del Coso Juan 
Published: November 2019

AimsThe main mechanism behind caffeine's ergogenicity lies in its tendency to bind to adenosine receptors, although other mechanisms might be involved. The aim of this investigation was to analyse the effects of caffeine on muscle oxygen saturation during exercise of increasing intensity.MethodsThirteen healthy and active individuals volunteered to participate in a randomized, double blind, placebo‐controlled crossover trial. During 2 different trials, participants either ingested a placebo (cellulose) or 3 mg/kg of caffeine. After waiting for 60 min to absorb the substances, participants underwent a maximal ramp cycle ergometer test (25 W/min). Near infrared spectrometers were positioned on each leg's vastus lateralis to monitor tissue O2 saturation. Blood lactate concentration was measured 1 min after the end of the exercise test.ResultsIn comparison to the placebo, the ingestion of caffeine improved the maximal wattage (258 ± 50 vs 271 ± 54 W, respectively, P < .001, effect size [ES] = 0.27; 95% confidence interval [CI] 0.14–0.35) and blood lactate concentration (11.9 ± 3.8 vs 13.7 ± 3.5 mmol/L, P = .029, ES = 0.38; 95% CI 0.14–0.75) at the end of the test. Caffeine increased muscle oxygen saturation at several exercise workloads with a main effect found in respect to the placebo (F = 6.28, P = .029; ES = 0.30 to 0.54; 95% CI 0.01–0.78). Peak pulmonary ventilation (124 ± 29 vs 129 ± 23 L/min, P = 0.035, ES = 0.25; 95% CI 0.07–0.40) and peak oxygen uptake (3.18 ± 0.70 vs 3.33 ± 0.88 L/min, P = 0.032, ES = 0.26; 95% CI 0.08–0.51) were also increased with caffeine.ConclusionAcute ingestion of 3 mg/kg of caffeine improved peak aerobic performance and increased peak pulmonary ventilation. In addition, caffeine induced changes in muscle oxygen saturation during submaximal workloads, suggesting that this mechanism might also contribute to caffeine's ergogenic effect.
What does mental health have to do with well‐being?
Authors: Keller Simon 
Published: November 2019

AbstractPositive mental health involves not the absence of mental disorder but rather the presence of certain mental goods. Institutions, practitioners, and theorists often identify positive mental health with well‐being. There are strong reasons, however, to keep the concepts of well‐being and positive mental health separate. Someone with high positive mental health can have low well‐being, someone with high well‐being can have low positive mental health, and well‐being and positive mental health sometimes conflict. But, while positive mental health and well‐being are not identical, there is an informative conceptual connection between them. Positive mental health usually contributes instrumentally to the living of a good human life, where a good human life includes (but is not limited to) well‐being.
Circular RNA hsa_circ_001895 serves as a sponge of microRNA‐296‐5p to promote clear cell renal cell carcinoma progression by regulating SOX12
Authors: Chen Zhuangfei , Xiao Kanghua , Chen Shijun , Huang Zehai , Ye Yunlin , Chen Tong 
Published: November 2019

AbstractThere is an urgent need to find novel potential therapeutic targets for the diagnosis and treatment of clear cell renal cell carcinoma (ccRCC) due to its highly invasive ability as a common urological malignant tumor. Circular RNAs (circRNAs) have been indicated as potentially critical mediators in various types of tumor progression. We first used qRT‐PCR analysis to find dysregulated circRNAs in ccRCC. A novel circRNA, hsa_circ_001895, was upregulated in ccRCC specimens and associated with metastatic properties of ccRCC. However, the tumorigenic mechanism of hsa_circ_001895 on ccRCC is yet to be found. We first indicated that hsa_circ_001895 predicted a poor prognosis in ccRCC patients. Additionally, overexpression of hsa_circ_001895 not only promoted cell proliferation, invasion and migration of ccRCC, but also inhibited cell apoptosis, whereas hsa_circ_001895 knockdown reversed the effect on ccRCC progression. In vivo s.c. xenotransplanted tumor model also showed that silencing hsa_circ_001895 could suppress in vivo ccRCC growth. Mechanistically, hsa_circ_001895 directly binds with microRNA (miR)‐296‐5p and inhibits its expression. Moreover, sex determining region Y (SRY)‐box 12 (SOX12) was identified as a target of miR‐296‐5p, the expression of which was suppressed by miR‐296‐5p. Notably, the inhibitory effect of hsa_circ_001895 on ccRCC progression was reversed by miR‐296‐5p inhibitor. In general, our findings indicated that hsa_circ_001895 may sponge miR‐296‐5p and promote SOX12 expression, which is the underlying mechanism of hsa_circ_001895‐induced ccRCC progression.
Synthesizing Character Animation with Smoothly Decomposed Motion Layers
Authors: Eom Haegwang , Choi Byungkuk , Cho Kyungmin , Jung Sunjin , Hong Seokpyo , Noh Junyong 
Published: November 2019

AbstractThe processing of captured motion is an essential task for undertaking the synthesis of high‐quality character animation. The motion decomposition techniques investigated in prior work extract meaningful motion primitives that help to facilitate this process. Carefully selected motion primitives can play a major role in various motion‐synthesis tasks, such as interpolation, blending, warping, editing or the generation of new motions. Unfortunately, for a complex character motion, finding generic motion primitives by decomposition is an intractable problem due to the compound nature of the behaviours of such characters. Additionally, decomposed motion primitives tend to be too limited for the chosen model to cover a broad range of motion‐synthesis tasks. To address these challenges, we propose a generative motion decomposition framework in which the decomposed motion primitives are applicable to a wide range of motion‐synthesis tasks. Technically, the input motion is smoothly decomposed into three motion layers. These are base‐level motion, a layer with controllable motion displacements and a layer with high‐frequency residuals. The final motion can easily be synthesized simply by changing a single user parameter that is linked to the layer of controllable motion displacements or by imposing suitable temporal correspondences to the decomposition framework. Our experiments show that this decomposition provides a great deal of flexibility in several motion synthesis scenarios: denoising, style modulation, upsampling and time warping.
When all life counts in conservation
Authors: Wallach Arian D. , Lundgren Erick , Batavia Chelsea , Nelson Michael Paul , Yanco Esty , Linklater Wayne L. , Carroll Scott P. , Celermajer Danielle , Brandis Kate J. , Steer Jamie , Ramp Daniel 
Published: November 2019

AbstractConservation science involves the collection and analysis of data. These scientific practices emerge from values that shape who and what is counted. Currently, conservation data are filtered through a value system that considers native life the only appropriate subject of conservation concern. We examined how trends in species richness, distribution, and threats change when all wildlife count by adding so‐called non‐native and feral populations to the International Union for Conservation of Nature Red List and local species richness assessments. We focused on vertebrate populations with founding members taken into and out of Australia by humans (i.e., migrants). We identified 87 immigrant and 47 emigrant vertebrate species. Formal conservation accounts underestimated global ranges by an average of 30% for immigrants and 7% for emigrants; immigrations surpassed extinctions in Australia by 52 species; migrants were disproportionately threatened (33% of immigrants and 29% of emigrants were threatened or decreasing in their native ranges); and incorporating migrant populations into risk assessments reduced global threat statuses for 15 of 18 species. Australian policies defined most immigrants as pests (76%), and conservation was the most commonly stated motivation for targeting these species in killing programs (37% of immigrants). Inclusive biodiversity data open space for dialogue on the ethical and empirical assumptions underlying conservation science.