bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative Opioid Education has No Effect on Opioid Use in Patients Undergoing Arthroscopic Rotator Cuff Repair: A Prospective, Randomized Clinical Trial
Authors: Bloom David A. , Baron Samuel L. , Luthringer Tyler A. , Alaia Michael J. , Strauss Eric J. , Jazrawi Laith M. , Campbell Kirk A. 
Published: December 2020

Objectives:
The purpose of this study was to determine whether a preoperative video-based opioid education reduced narcotics consumption after arthroscopic rotator cuff repair in opioid-naive patients.

Methods:
This was a single-center randomized controlled trial. Preoperatively, the control group received our institution's standard of care for pain management education, whereas the experimental group watched an educational video on the use of opioids. Patients were discharged with 30 × 5 mg/325 mg oxycodone-acetaminophen prescribed: 1 to 2 tablets every 4 to 6 hours. They were contacted daily and asked to report opioid use and visual analog scale pain. A chart review at 3 months post-op was used to analyze for opioid refills.

Results:
A total of 130 patients completed the study (65 control and 65 experimental). No statistically significant differences were noted in patient demographics between groups (P > 0.05). Patients in the education group did not use a statistically significant different number of narcotics than the control group throughout the first postoperative week (14.0 pills experimental versus 13.7 pills control, P = 0.60). No statistically significant differences were noted between groups at follow-regarding the rate of prescription refills (P > 0.05).

Conclusion:
This study suggests that preoperative video-based opioid education may have no effect on reducing the number of narcotic pills consumed after arthroscopic rotator cuff repair.

Clinical relevance:
Data exist to suggest that preoperative video-based opioid education has an effect on postoperative consumption; however, the effect of this education in the setting of already-limited opioid-prescribing is not known.

ClinicalTrials.gov identifier:
NCT04018768
Geluidregulering van industrieterreinen onder de Omgevingswet
Authors: de Haas J. (Joeri) 
Published: December 2020

Geluidregulering van industrieterreinen onder de Omgevingswet. Verbeterde woningbouwmogelijkheden nabij industrieterreinen, hoger beschermingsniveau tegen industrielawaai?
Auteur gaat in dit artikel in op de vraag in hoeverre de toekomstige geluidregulering, na inwerkingtreding van de Omgevingswet, ten opzichte van het huidige recht verbeterde mogelijkheden biedt voor het realiseren van woningbouw nabij industrie- en bedrijventerreinen.
Vrije aanbiederskeuze binnen het sociaal domein: een vergelijking met het hinderpaalcriterium
Authors: Wallage B. , Koelewijn W.I. 
Published: December 2020

Vrije aanbiederskeuze binnen het sociaal domein: een vergelijking met het hinderpaalcriterium
In dit artikel onderzoeken de auteurs op welke wijze het recht op vrije artsenkeuze is uitgewerkt binnen het sociaal domein. Daarbij wordt een vergelijking gemaakt met artikel 13 lid 1 Zvw en het daaruit volgende hinderpaalcriterium.
Kroniek rechtspraak rechten van de mens
Authors: Hendriks A.C. 
Published: December 2020

Kroniek rechtspraak rechten van de mens
Het Europees Hof voor de Rechten van de Mens (EHRM of Hof) heeft in de periode van september 2019 tot en met augustus 2020 weer diverse uitspraken gedaan over gezondheidsrechtelijke onderwerpen. Veel uitspraken borduren voort op of geven een nadere uitleg aan zaken waarover het Hof zich eerder heeft gebogen. Tegelijkertijd komt uit de uitspraken van afgelopen jaar het beeld naar voren dat het Hof in toenemende mate belang hecht aan de beschermingsplicht van de overheid, in het bijzonder bij gedetineerden, psychiatrische en verstandelijk beperkte patiënten en personen die anderszins kwetsbaar zijn.
The Importance of Food Control for Retail Development – Evidence Using Adaptive Neuro-Fuzzy Inference System Approach
Authors: Sokolov Mladenović Svetlana , Ćuzović Sreten , Mladenović Igor , Stojković Dragan 
Published: December 2020

Retail and retail development have become increasingly important in the economies of a number of countries in recent years. Given that retail chains are in direct contact with consumers, food retail control is important for both consumers and retailers. Additionally, food control is an important business segment of all companies involved in the food distribution chain, from food production, processing, storage, and sales to end consumers. On the one hand, the right to healthy and safe products is one of the basic consumer rights. On the other hand, retail chains tend to deliver healthy and safe products to consumers, using the principle of efficiency and positive business performance. In line with the above, i.e. food retailers’ challenge to satisfy consumer demands for healthy and safe products, but also to achieve positive business performance, the aim of this paper is to analyse the importance of food control for retail development, with particular reference to the market of the Republic of Serbia. For this purpose, empirical research is carried out on a sample of 169 food retailers. Using the available financial data, as well as data obtained from field research, the paper tests hypothesis on the impact of food control, as measured by the percentage allocation for the introduction of food safety standards, on food retail performance. The ANFIS method is used, and the results show positive impact of food control on food retail development in the Republic of Serbia.
Claude-Henri Grignon face à la Révolution tranquille. Les échos de Valdombre1
Authors: Hotte Ghyslain 
Published: December 2020

Cet article propose une analyse de la pensée de Claude-Henri Grignon (1894-1976), auteur prolifique et pamphlétaire originaire de Sainte-Adèle (Québec). Si son nom évoque immédiatement son oeuvre littéraire, on connaît moins bien son oeuvre polémique écrite dans le contexte de la Révolution tranquille. En effet, tout au long de la décennie 1960, Grignon livre plusieurs conférences et publie de nombreux articles sur diverses questions sociales. Durant cette période, le traditionaliste Grignon s’oppose aux réformes politiques, institutionnelles et sociales réalisées dans la foulée de la Révolution tranquille. L’historiographie a laissé peu de place aux penseurs dits « contre-révolutionnaires tranquilles ». Ce texte tente de combler cette lacune.
Commercial Multiplex Polymerase Chain Reaction versus Periodic Acid–Schiff Testing for the Diagnosis of Onychomycosis
Authors: Caldwell Bryan , Uchmanowicz Karen , Kawalec Jill S. , Petrofski Stephanie , Kurzel Carl 
Published: December 2020

Background
Diagnosis of onychomycosis using the periodic acid–Schiff (PAS) test for sensitive identification of hyphae and fungal culture for identification of species has become the mainstay for many clinical practices. With the advent of polymerase chain reaction (PCR) testing, physicians can identify a fungal toenail infection quickly with the added benefit of species identification. We compared PAS testing with multiplex PCR testing from a clinical perspective.

Methods
A total of 209 patients with clinically diagnosed onychomycosis were recruited. A high-resolution picture was taken of the affected hallux nail, and the nail was graded using the Onychomycosis Severity Index. A proximal sample of the affected toenail and subungual debris were obtained and split into two equal samples. One sample was sent for multiplex PCR testing and the other for PAS testing. The results were analyzed and compared.

Results
Six patients were excluded due to insufficient sample size for PCR testing. Of the remaining 203 patients, 109 (53.7%) tested positive with PAS, 77 (37.9%) tested positive with PCR. Forty-one patients tested positive with PAS but negative with PCR, and nine tested positive with PCR but negative with PAS.

Conclusions
Physicians should continue the practice of using PAS biopsy staining for confirmation of a fungal toenail infection before using oral antifungal therapy. Because multiplex PCR allows species identification, some physicians may elect to perform both tests.
Attitudes and Knowledge Regarding Pain Management and Addiction in Massachusetts: A Mixed Methods Study on Podiatric Residents
Authors: Sundling Rebecca A. 
Published: December 2020

Background
The opioid epidemic has hit disastrous levels across the United States. Many attempts have been made to counteract this, including policy changes and modification of provider and patient behavior. The purpose of this study was to understand the current state of podiatric residents' knowledge regarding pain management and addiction.

Methods
This study used mixed quantitative-qualitative methods. Two focus groups were conducted with two podiatric residency programs to understand current issues and inform the creation of a survey. A 30-question survey was created and peer reviewed to assess general pain management knowledge, levels of confidence in pain management and addiction, and areas for improvement.

Results
Pain management education in podiatry is mainly focused on opioids. These concepts are often taught in a nonstandardized method, which does not often include nonopioid alternatives. Knowledge of risk factors for addiction was lacking, whereas knowledge of behaviors concerning for addiction was more bountiful. Thirty-three surveys were completed of a possible 39. A knowledge score was created from eight survey questions for a total of 10 points, with an average score of 4.61. There was no statistical difference between those with and without a pain management rotation. Nearly all residents felt comfortable managing surgical pain. The residents are “never” or “only occasionally” inquiring about risk factors for addiction. Questions asked also suggest that the residents are not thinking about their role within the opioid epidemic.

Conclusions
As the opioid epidemic grows, it is imperative to examine the causes and solutions to the problem. Focusing efforts on educating resident physicians is one method to address the issue. The results of this study show that pain management basics need to be reinforced and more time must be spent emphasizing the importance of thorough patient histories and educating patients when prescribing pain medication.
Ultrasound-Guided Decompression of the Intermetatarsal Nerve for Morton's Neuroma: A Novel Closed Surgical Technique
Authors: Iborra-Marcos Alvaro , Villanueva-Martinez Manuel , Barrett Stephen L. , Sanz-Ruiz Pablo 
Published: December 2020

Background
This study describes the technique for decompression of the intermetatarsal nerve in Morton's neuroma by ultrasound-guided surgical resection of the transverse intermetatarsal ligament. This technique is based on the premise that Morton's neuroma is primarily a nerve entrapment disease. As with other ultrasound-guided procedures, we believe that this technique is less traumatic, allowing earlier return to normal activity, with less patient discomfort than with traditional surgical techniques.

Methods
We performed a pilot study on 20 cadavers to ensure that the technique was safe and effective. No neurovascular damage was observed in any of the specimens. In the second phase, ultrasound-guided release of the transverse intermetatarsal ligament was performed on 56 patients through one small (1- to 2-mm) portal using local anesthesia and outpatient surgery.

Results
Of the 56 participants, 54 showed significant improvement and two did not improve, requiring further surgery (neurectomy). The postoperative wound was very small (1–2 mm). There were no cases of anesthesia of the interdigital space, and there were no infections.

Conclusions
The ultrasound-guided decompression of intermetatarsal nerve technique for Morton's neuroma by releasing the transverse intermetatarsal ligament is a safe, simple method with minimal morbidity, rapid recovery, and potential advantages over other surgical techniques. Surgical complications are minimal, but it is essential to establish a good indication because other biomechanical alterations to the foot can influence the functional outcome.
Control and synchronization of fractional‐order chaotic satellite systems using feedback and adaptive control techniques
Authors: Kumar Sanjay , Matouk Ahmed E. , Chaudhary Harindri , Kant Shashi 
Published: December 2020

SummaryIn this article, we present the basic concepts of fractional calculus and control and synchronization of fractional‐order chaotic satellite system . Existence and uniqueness solutions of fractional‐order satellite system are discussed and local stability of the system at the equilibrium points are studied. The lowest dimension of chaotic attractor of satellite system is 2.88 which is obtained through utilization of the fractional dynamics and computational simulation. Lyapunov exponents and bifurcation diagrams are drawn to measure the existence of chaos in the system. Feedback control method for chaos control in the fractional‐order satellite system is achieved. Synchronization of two identical noninteger order chaotic satellite systems are achieved through adaptive control methodology.
Thermoelectric Properties of Novel Semimetals: A Case Study of YbMnSb2
Authors: Pan Yu , Fan Feng‐Ren , Hong Xiaochen , He Bin , Le Congcong , Schnelle Walter , He Yangkun , Imasato Kazuki , Borrmann Horst , Hess Christian , Büchner Bernd , Sun Yan , Fu Chenguang , Snyder G. Jeffrey , Felser Claudia 
Published: December 2020

AbstractThe emerging class of topological materials provides a platform to engineer exotic electronic structures for a variety of applications. As complex band structures and Fermi surfaces can directly benefit thermoelectric performance it is important to identify the role of featured topological bands in thermoelectrics particularly when there are coexisting classic regular bands. In this work, the contribution of Dirac bands to thermoelectric performance and their ability to concurrently achieve large thermopower and low resistivity in novel semimetals is investigated. By examining the YbMnSb2 nodal line semimetal as an example, the Dirac bands appear to provide a low resistivity along the direction in which they are highly dispersive. Moreover, because of the regular‐band‐provided density of states, a large Seebeck coefficient over 160 µV K−1 at 300 K is achieved in both directions, which is very high for a semimetal with high carrier concentration. The combined highly dispersive Dirac and regular bands lead to ten times increase in power factor, reaching a value of 2.1 mW m−1 K−2 at 300 K. The present work highlights the potential of such novel semimetals for unusual electronic transport properties and guides strategies towards high thermoelectric performance.
Extracellular‐Matrix‐Reinforced Bioinks for 3D Bioprinting Human Tissue
Authors: De Santis Martina M. , Alsafadi Hani N. , Tas Sinem , Bölükbas Deniz A. , Prithiviraj Sujeethkumar , Da Silva Iran A. N. , Mittendorfer Margareta , Ota Chiharu , Stegmayr John , Daoud Fatima , Königshoff Melanie , Swärd Karl , Wood Jeffery A. , Tassieri Manlio , Bourgine Paul E. , Lindstedt Sandra , Mohlin Sofie , Wagner Darcy E. 
Published: December 2020

AbstractRecent advances in 3D bioprinting allow for generating intricate structures with dimensions relevant for human tissue, but suitable bioinks for producing translationally relevant tissue with complex geometries remain unidentified. Here, a tissue‐specific hybrid bioink is described, composed of a natural polymer, alginate, reinforced with extracellular matrix derived from decellularized tissue (rECM). rECM has rheological and gelation properties beneficial for 3D bioprinting while retaining biologically inductive properties supporting tissue maturation ex vivo and in vivo. These bioinks are shear thinning, resist cell sedimentation, improve viability of multiple cell types, and enhance mechanical stability in hydrogels derived from them. 3D printed constructs generated from rECM bioinks suppress the foreign body response, are pro‐angiogenic and support recipient‐derived de novo blood vessel formation across the entire graft thickness in a murine model of transplant immunosuppression. Their proof‐of‐principle for generating human tissue is demonstrated by 3D bioprinting human airways composed of regionally specified primary human airway epithelial progenitor and smooth muscle cells. Airway lumens remained patent with viable cells for one month in vitro with evidence of differentiation into mature epithelial cell types found in native human airways. rECM bioinks are a promising new approach for generating functional human tissue using 3D bioprinting.
Multifunctional Vortex Beam Generation by a Dynamic Reflective Metasurface
Authors: Liu Baiyang , He Yejun , Wong Sai‐Wai , Li Yin 
Published: December 2020

AbstractIn recent decades, metasurfaces have attracted considerable interest to generate vortex beams, that is, orbital angular momentum (OAM) carrying beams. However, the existing OAM metasurfaces are mostly fixed‐mode or with single function. Here a concept of multifunctional vortex beam generation is proposed, and is realized by a dynamic reflective metasurface which is capable of controlling the vortex beam spatiotemporally. The proposed metasurface has the ability to control OAM mode and to observe rotational Doppler effect. As proof of concept, it is presented that the proposed metasurface can generate an l = −1 or l = +1 OAM mode reconfigurable beam, and an l = +1 spinning OAM beam with rotational Doppler effect. Both simulated and measured results show the effectiveness of the proposed multifunctional OAM metasurface which has two different functionalities. The proposed multifunctional OAM metasurface may have potential applications in OAM multiplexing communications and harmonics manipulation by rotational Doppler effect.
Sulfoximines with α‐Ketoester Functionalities at Nitrogen from Cyanoacetates and Air
Authors: Wang Chenyang , Wang Han , Bolm Carsten 
Published: December 2020

AbstractSulfoximines with nitrogen‐bound α‐ketoester units are efficiently prepared by an operationally simple one‐pot reaction sequence in air starting from methoxy(mesyloxy)iodobenzene, NH‐sulfoximines, and cyanoacetates. Key of the process is the in‐situ formation of hypervalent iodine reagents, which serve as electrophilic sulfoximidoyl sources.magnified image
Clinical and molecular analysis of 26 individuals with Noonan syndrome in a reference institution in Colombia
Authors: Lores Juliana , Prada Carlos E. , Ramírez‐Montaño Diana , Nastasi‐Catanese José A. , Pachajoa Harry 
Published: December 2020

AbstractOur aim was to characterize the phenotype and genotype of individuals with Noonan syndrome in Colombia. There are published cohorts of Noonan individuals from several countries in Latin America including Brazil, Chile, and Argentina, but none from Colombia. We described 26 individuals with NS from a single large referral center in the South West of Colombia using an established database in the genetics department and hospital records search using ICD‐10 codes. All patients included in this study were evaluated by a medical geneticist and have molecular confirmation of NS diagnosis. The median age at referral was 3.5 years (range, 0–39), and at molecular diagnosis was 5 years (range, 0–40). Patients mostly originated from the southwest region of Colombia (19/26, 73%). Pathogenic variants in PTPN11 are the most common cause of NS in Colombian individuals followed by SHOC2 and SOS1 variants. The prevalence of cardiomyopathy was low in this population compared to other populations. Further research is needed with a larger sample size and including different regions of Colombia to correlate our findings. This study provides new information about time to diagnosis of NS in Colombia, genotypes, and provides important information to help develop guidelines for diagnosis and management of this disease in the region.
Genuine Quadripartite Continuous‐Variable Entanglement in Symmetric Cascaded Four‐Wave Mixing Process
Authors: Zhang Da , Ahmed Irfan , Li Changbiao , Zhang Yanpeng 
Published: December 2020

AbstractThe symmetric cascaded four‐wave mixing process is a phase‐insensitive and easy‐to‐implement technology to prepare quadripartite entanglement. However, it has not yet been discussed whether the state generated by this method is genuinely entangled. Here, it is shown that the genuine quadripartite entanglement criteria previously derived are not applicable to the symmetric cascaded scheme. Thus some more effective sufficient conditions are derived for detecting genuine entanglement in this work. The existence of genuine quadripartite entanglement is then confirmed through different entanglement witnesses. Under the premise that the quadripartite state is genuinely entangled, the quantum gain of the first‐stage determines the optimal range of the quantum gain of second‐stage. Finally, it is show that the four output modes are genuinely entangled within the appropriate quantum gain ranges when the optical loss of each step of the cascaded system is less than 10%. The results pave the way for the experimental generation of genuine quadripartite entanglement in symmetric cascaded scheme.
Simultaneous Dual‐Gene Diagnosis of SARS‐CoV‐2 Based on CRISPR/Cas9‐Mediated Lateral Flow Assay
Authors: Xiong Erhu , Jiang Ling , Tian Tian , Hu Menglu , Yue Huahua , Huang Mengqi , Lin Wei , Jiang Yongzhong , Zhu Debin , Zhou Xiaoming 
Published: December 2020

AbstractFew methods for the detection of SARS‐CoV‐2 currently have the capability to simultaneously detect two genes in a single test, which is a key measure to improve detection accuracy, as adopted by the gold standard RT‐qPCR method. Developed here is a CRISPR/Cas9‐mediated triple‐line lateral flow assay (TL‐LFA) combined with multiplex reverse transcription‐recombinase polymerase amplification (RT‐RPA) for rapid and simultaneous dual‐gene detection of SARS‐CoV‐2 in a single strip test. This assay is characterized by the detection of envelope (E) and open reading frame 1ab (Orf1ab) genes from cell‐cultured SARS‐CoV‐2 and SARS‐CoV‐2 viral RNA standards, showing a sensitivity of 100 RNA copies per reaction (25 μL). Furthermore, dual‐gene analysis of 64 nasopharyngeal swab samples showed 100 % negative predictive agreement and 97.14 % positive predictive agreement. This platform will provide a more accurate and convenient pathway for diagnosis of COVID‐19 or other infectious diseases in low‐resource regions.
Three‐Component Alkene Difunctionalization by Direct and Selective Activation of Aliphatic C−H Bonds
Authors: Xu Sheng , Chen Herong , Zhou Zhijun , Kong Wangqing 
Published: December 2020

AbstractCatalytic alkene difunctionalization is a powerful strategy for the rapid assembly of complex molecules and has wide range of applications in synthetic chemistry. Despite significant progress, a compelling challenge that still needs to be solved is the installation of highly functionalized C(sp3)‐hybridized centers without requiring pre‐activated substrates. We herein report that inexpensive and easy‐to‐synthesize decatungstate photo‐HAT, in combination with nickel catalysis, provides a versatile platform for three‐component alkene difunctionalization through direct and selective activation of aliphatic C−H bonds. Compared with previous studies, the significant advantages of this strategy are that the most abundant hydrocarbons are used as feedstocks, and various highly functionalized tertiary, secondary, and primary C(sp3)‐hybrid centers can be easily installed. The practicability of this strategy is demonstrated in the selective late‐stage functionalization of natural products and the concise synthesis of pharmaceutically relevant molecules including Piragliatin.