bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular mechanism of SARS-CoV-2 inactivation by temperature
Authors: Martí Didac , Torras Juan , Betran Oscar , Turon Pau , Alemán Carlos 
Published: October 2020

AbstractRecent studies have shown that SARS-CoV-2 virus can be inactivated by effect of heat, even though, little is known about the molecular changes induced by the temperature. Here, we unravel the basics of such inactivation mechanism over the SARS-CoV-2 spike glycoprotein by executing atomistic molecular dynamics simulations. Both theclosed downandopen upstates, which determine the accessibility to the receptor binding domain, were considered. Results suggest that the spike undergoes drastic changes in the topology of the hydrogen bond network while salt bridges are mainly preserved. Reorganization in the hydrogen bonds structure produces conformational variations in the receptor binding subunit and explain the thermal inactivation of the virus. Conversely, the macrostructure of the spike is preserved at high temperature because of the retained salt bridges. The proposed mechanism has important implications for engineering new approaches to inactivate the SARS-CoV-2 virus.
The Design Principles of Discrete Turing Patterning Systems
Authors: Leyshon Thomas , Tonello Elisa , Schnoerr David , Siebert Heike , Stumpf Michael P.H. 
Published: October 2020

AbstractThe formation of spatial structures lies at the heart of developmental processes. However, many of the underlying gene regulatory and biochemical processes remain poorly understood. Turing patterns constitute a main candidate to explain such processes, but they appear sensitive to fluctuations and variations in kinetic parameters, raising the question of how they may be adopted and realised in naturally evolved systems. The vast majority of mathematical studies of Turing patterns have used continuous models specified in terms of partial differential equations. Here, we complement this work by studying Turing patterns using discrete cellular automata models. We perform a large-scale study on all possible two-species networks and find the same Turing pattern producing networks as in the continuous framework. In contrast to continuous models, however, we find these Turing pattern topologies to be substantially more robust to changes in the parameters of the model. We also find that diffusion-driven instabilities are substantially weaker predictors for Turing patterns in the discrete modelling framework in comparison to the continuous case, and show that a more refined criterion constitutes a stronger predictor. The similarity of the results for the two modelling frameworks suggests a deeper underlying principle of Turing mechanisms in nature. Together with the larger robustness in the discrete case this suggests that Turing patterns may be more robust than previously thought.
Programmable Aggregation of Artificial Cells with DNA Signals
Authors: Qiu Hengming , Li Feiran , Du Yancheng , Li Ruixin , Hyun Ji Yeon , Lee Sei Young , Choi Jong Hyun 
Published: October 2020

ABSTRACTCell aggregation is a complex behavior, which is closely related to the viability, differentiation, and migration of cells. An effort to create synthetic analogs could lead to considerable advances in cell physiology and biophysics. Rendering and modulating such a dynamic artificial cell system require mechanisms for receiving, transducing, and transmitting intercellular signals, yet effective tools are limited at present. Here we construct synthetic cells from engineered lipids and show their programmable aggregation behaviors using DNA oligonucleotides as a signaling molecule. The artificial cells have transmembrane channels made of DNA origami that are used to recognize and process intercellular signals. We demonstrate that multiple small vesicles aggregate onto a giant vesicle after a transduction of external DNA signals by an intracellular enzyme, and that the small vesicles dissociate when receiving ‘release’ signals. This work provides new possibilities for building synthetic protocells capable of chemical communication and coordination.
Learning peg-in-hole assembly using Cartesian DMPs with feedback mechanism
Authors: Liu Nailong , Zhou Xiaodong , Liu Zhaoming , Wang Hongwei , Cui Long 
Published: October 2020

Purpose
This paper aims to enable the robot to obtain human-like compliant manipulation skills for the peg-in-hole (PiH) assembly task by learning from demonstration.

Design/methodology/approach
A modified dynamic movement primitives (DMPs) model with a novel hybrid force/position feedback in Cartesian space for the robotic PiH problem is proposed by learning from demonstration. To ensure a compliant interaction during the PiH insertion process, a Cartesian impedance control approach is used to track the trajectory generated by the modified DMPs.

Findings
The modified DMPs allow the robot to imitate the trajectory of demonstration efficiently and to generate a smoother trajectory. By taking advantage of force feedback, the robot shows compliant behavior and could adjust its pose actively to avoid a jam. This feedback mechanism significantly improves the dynamic performance of the interactive process. Both the simulation and the PiH experimental results show the feasibility and effectiveness of the proposed model.

Originality/value
The trajectory and the compliant manipulation skill of the human operator can be learned simultaneously by the new model. This method adopted a modified DMPs model in Cartesian space to generate a trajectory with a lower speed at the beginning of the motion, which can reduce the magnitude of the contact force.
Failure prediction in electrical connector assembly: a case in automotive assembly process
Authors: Altinisik Armagan , Yildirim Utku 
Published: October 2020

Purpose
Electrical defects cover an important part of assembly defects and strongly affect the vehicle system performance. Almost 40% of assembly defects are classified as human errors and electrical connection failures represent a significant part of them. Humans still remain a cost-effective solution for the flexible manufacturing systems with increasing product complexity. So, understanding human behaviors is still a challenging task. The purpose of this study is to define, prioritize and validate the critical factors for the complexity of electrical connector plugin process.

Design/methodology/approach
The critical variables were defined by the expert team members. The required number of measurements and variables were revised resulting preliminary analysis of binary logistic regression. After the revision of measurement plan, the list of critical input variables and the mathematical model were defined. The model has been validated by the fitted values of the residuals (FITS analysis).

Findings
To the best of the authors’ knowledge, this is one of the limited studies, which defines the critical factors for electrical connection process complexity. Female connector harness length, connector width/height/length differences, operator sense of correct connector matching and ergonomy were defined as the factors with the highest impact on the failure occurrence. The obtained regression equation strongly correlates the failure probability.

Practical implications
The obtained mathematical model can be used in new model development processes both for the product and assembly process design (ergonomy, accessibility and lay-out).

Originality/value
The obtained risk factors demonstrated a strong correlation with assembly process complexity and failure rates. The output of this study would be used as an important guide for process (assembly line ergonomy, accessibility and lay-out) and product design in new model development and assembly ramp-up phases.
Framing autism in newspaper media: an example from Finland
Authors: Pesonen Henri , Itkonen Tiina , Saha Mari , Nordahl-Hansen Anders 
Published: October 2020

Purpose
Media play a significant role in the process of raising public awareness about autism spectrum disorder (ASD). Despite an increase in ASD media coverage, there is scarcity of research that examines how the actual frame is constructed and how the news stories are narrated. This study aims to examine the extent to which Finnish print media papers extend medical and societal narration of ASD to other issue domains and the extent to which newspaper stories use a positive, negative or neutral narrative.

Design/methodology/approach
The authors analyzed 210 full newspaper reports from the largest daily appearing newspaper by circulation in Finland from 1990 to 2016. The authors used the newspaper’s electronic database to conduct a systematic papers search. The authors then used coding scheme about news story framing, which was followed by a detailed content analysis of the papers.

Findings
Approximately two-thirds of the papers consisted of a straightforward informational or clinical lens to educate the public (n = 110). This is in line with international studies. However, the authors’ analysis revealed four additional themes of medical and societal ASD reporting.

Social implications
The study increases understanding about how the media can shape the public perception of ASD, which in turn might influence how autistic individuals are accepted in the society, as well as how they feel that they belong.

Originality/value
While ASD itself is at the center of neutral news reporting, this study’s results imply how to construct ASD from new paradigms. Linking ASD to a culture, and thus extending it to the more commonly accepted notion of deafness as a culture, might shape the public’s perceptions about ASD.
The role of innovation capability in the relationship between marketing capability and new product development: evidence from the telecommunication sector
Authors: Aljanabi Abdulqadir Rahomee Ahmed 
Published: October 2020

PurposeThe purpose of this study is to examine the relationships between marketing and innovation capabilities and new product development (NPD), including the potential mediating and moderating roles of innovation capability (IC) in the relationship between marketing capability (MC) and NPD.Design/methodology/approachData were collected from telecommunication firms operating in the Kurdistan region of Iraq using a self-administered questionnaire. Of 556 distributed questionnaires, 272 were returned and used for statistical analysis. To analyze the data, a structural equation model (SEM) was developed to test both measurement and structural models.FindingsBoth innovation capability and marketing capability positively impact NPD. Furthermore, IC not only strengthens the relationship between MC and NPD but also serves as a mechanism enabling this relationship.Originality/valueThis study offers NPD researchers a deeper understanding of the capabilities that may affect the NPD process. From a theoretical perspective, previous studies focused exclusively on IC and MC separately and thus did not capture the relationships between these antecedents and NPD. Another valuable contribution of this study to the NPD literature is the inclusion of different roles of IC within the frame of MC and NPD. For practitioners, this study outlines novel combinations of antecedents leading to better levels of NPD.
Does currency misalignment matter for economic growth? – Evidence from Turkey
Authors: Mamun Abdulla Hil , Bal Harun , Basher Shahanara 
Published: October 2020

PurposeThe study mainly aims to examine the currency misalignment of Turkish lira and evaluate if it has an impact on economic growth of Turkey.Design/methodology/approachIt relies on Johansen cointegration technique for measuring currency misalignment relying on single-equation approach and the autoregressive distributed lag (ARDL) approach to evaluate how misalignment affects economic growth. The sample period covers from 1980 to 2016.FindingsThe study identifies that terms of trade, relative productivity differences, net foreign asset, investment and trade openness determine the equilibrium REER of Turkey, and the degree of currency misalignment is observed at a substantial level. The outcome of the ARDL approach suggests that higher currency misalignment reduces economic growth. Turning to the separate impacts of undervaluation and overvaluation, while the former falters economic growth, the later promotes it, a finding contrary to the conventional expectation. Therefore, the use of exchange rate as a policy variable is a critical concern to avoid misalignment for sustained economic growth.Practical implicationsThe anti-growth effect of undervaluation and misalignment is an indication of redistribution of income which could be verified by examining the aggregate consumption behavior of the economy in response to RER movements.Originality/valueThe impacts of currency undervaluation and overvaluation on economic growth of Turkey have been studied in a number of time-series studies. But there is no documented study on the role of currency misalignment on Turkish economic growth. This study is the first that examines how the economic growth of Turkey is influenced by currency misalignment together with the impact of undervaluation and overvaluation.
Sustainable value creation? Entrepreneurial orientations in the football industry
Authors: Bull Mike , Whittam Geoff 
Published: October 2020

PurposeIn this paper the authors investigate precarious value creation in English football clubs. They examine strategic, economic, cultural and social capital to analyse the orientations of legal owners of football clubs (entrepreneurs) and the implications for moral owners (the fans). Their research question is not if entrepreneurs create value – but whether the value created is productive or destructive.Design/methodology/approachThe research design is a case study of the professional football industry, specifically 44 football clubs in the top two professional divisions in England, namely the English Premier League and the English Football League Championship. The authors’ methodology is secondary textual data. Their approach is to examine official club statements, triangulated with regional and national press reports, fan accounts and narratives from published artefacts; fan blogs and websites.FindingsThe “opening up” of the professional football industry in England to market forces in 1983 has subsequently attracted entrepreneurs that use football clubs as artefacts to pursue other business interests. Over-grazing on strategic and economic capital at the expense and exploitation of social and cultural capital exists. As entrepreneurial opportunities to exploit a football club's assets becomes more apparent, the unique relationship between club and fan is being strained. The authors observe detachment, disenchantment and protest.Research limitations/implicationsThe data sought for this study design was necessarily in the public domain and therefore drawn from secondary sources. The scope was English football and the top two divisions, thus the findings are context specific to that region and level.Practical implicationsFor policy, the authors call for a new government inquiry into football ownership in English football, re-examining heritage, purpose and value creation.Social implicationsFootball fans are the majority stakeholder in the football industry but are under-represented in English football because of the private ownership of football clubs. Fans are, however, a barometer for how their owners are acting as custodians of their clubs and if the value created by entrepreneurs is productive or exploitative.Originality/valueThis paper has value in drawing attention to this unique and ignored industry from an entrepreneurship perspective, provoking a call for further research to explore this phenomenon. Sustainable value creation may be a useful framework for further research in this and other industries.
The roles of school leaders in developing future-ready learners: the case of Singapore
Authors: Wong Choun Pei , Ng David 
Published: October 2020

PurposeAn education system can only be successful if it can develop future-ready learners who can continue to learn after graduation, take on their future lifework and thrive in the future society and environment. This article examines the economic, social and environmental trajectories of Singapore and proposes that it is important for future-ready learners to develop habits of practices that will support the skills, knowledge and values that are pertinent to these trajectories.Design/methodology/approachSchool leaders are responsible for creating environments and implementing practices that are conducive for fostering habits of practices that are crucial for future-ready outcomes. The authors discuss the inadequacies of traditional teaching and learning practices in supporting these habits and elucidate how newer paradigms such as constructivism, connectivism, coagency and communities of practice might be more useful in achieving this. The authors also present a case study of a school leadership preparation programme that aims to develop future-ready learners.FindingsThis paper provides insights into how newer paradigms of teaching and learning can be supportive for developing desirable habits of practices for future readiness.Originality/valueThis discussion piece introduces a fresh concept – habits of practices – that is relevant in preparing future-ready learners in Singapore.
The role of blockchain in reducing the impact of barriers to humanitarian supply chain management
Authors: Ozdemir Ali Ihsan , Erol Ismail , Ar Ilker Murat , Peker Iskender , Asgary Ali , Medeni Tunc Durmus , Medeni Ihsan Tolga 
Published: October 2020

PurposeThe objective of this study is to investigate the role of blockchain in reducing the impact of barriers to humanitarian supply chain management (HSCM) using a list of blockchain benefits.Design/methodology/approachA decision aid was used to explore the suitability of blockchain in humanitarian supply chains. To achieve that, first, a list of barriers to HSCM was identified. Then, the intuitionistic fuzzy decision-making trial and evaluation laboratory (IF–DEMATEL) method was utilized to determine the relationships and the level of interdependencies among the criteria. Finally, the intuitionistic fuzzyanalytic network process (IF–ANP) technique was employed, as it successfully handles dependencies among the criteria.FindingsThe findings of this study suggest that interorganizational barriers are the most suitable ones, the impacts of which blockchain may alleviate. This study further suggests that trust turned out to be the most significant benefit criterion for the analysis.Research limitations/implicationsThe readers should construe the findings of this study with caution since it was carried out using the data collected from the experts of a particular country. Moreover, the proposed decision aid contemplates a limited set of criteria to assess a possible role of blockchain in overcoming the barriers to HSCM.Practical implicationsThe findings of this study can assist humanitarian supply chain managers to make more judicious assessments on whether they implement the blockchain in humanitarian supply chain operations. Specifically, this research may help decision makers to identify the certain barriers, the impact of which may be reduced by using the blockchain. The findings of this research will also help various decision makers make more rational decisions and allocate their resources more effectively.Originality/valueTo the best of authors’ knowledge, no single study exists to investigate the role of blockchain in reducing the impact of barriers to HSCM using an intuitionistic fuzzy multi-criteria decision-making approach.
Do sustainability practices influence university quality? A Colombian case study
Authors: Hernandez-Diaz Paula M. , Polanco Jorge-Andrés , Castaño Sandra Milena 
Published: October 2020

PurposeThis paper aims to know how university’s strategic managers, from botacademic and administrative systems, perceive the relationship between sustainability and accreditation as sustainability incorporation and the quality of their processes are amongst the actual challenges of universities.Design/methodology/approachThis paper opted for an inductive, exploratory study using the case study approach, including 19 in-depth interviews to administrative and academic managers in a private, high-quality certified university in Colombia. The data were assessed using the content analysis methodology. The Colombian accreditation guidelines were the base to analyse the data as accreditation is part of the quality assurance system.FindingsThis paper provides empirical insights into how the implementation of sustainability in universities relates to the Colombian accreditation factors. The main links found were in the areas of the university’s social impact and organisational responsibility, which are highly relevant to graduates, external stakeholders and sustainability skills. Sustainable campus operation was associated with environmental management and improvement of the quality of the physical plant, with social and economic benefits in the long-term. Additionally, this research found a need for administrative and academic managers to understand and increase their commitment to sustainability.Research limitations/implicationsBecause it was a case study, results are not generalisable. Consequently, further research on similar lines is required to universalise the mentioned observation and results.Practical implicationsThe accreditation factors related to sustainability, inductively defined and exposed in this paper, provide an idea of how sustainability implementation could contribute to higher education quality assurance.Originality/valueThis paper contributes to filling the knowledge gap about embedding sustainability in Latin-American universities. This paper postulates a starting point considering accreditation standards and the link of the strategic manager’s perceptions of sustainability.
Personalized recommendation framework design for online tourism: know you better than yourself
Authors: Wang Xiaoqian 
Published: October 2020

PurposeThis study aims to create an idea and a framework to enhance customer stickiness and improve transformation efficiency flow of tourism products from online to offline platforms through the application of personalized recommendation technology.Design/methodology/approachStudies on an overview of progress in current personalized recommendation research, business scenario analysis of online tourism and some possible logical limitations discussion are required for improvement. This study clarifies concepts including online tourism user behavior and generated data, user preference themes and spaces, user models and image and user-product (two-dimensional matrix, etc.). The author then creates a user portrait based on behavior data convergence to locate the user's role from both horizontal and vertical dimensions and also clear the logical levels and associations among them, verifying the similarity in measurement and calculation and optimizing the implementation of the personalized recommendation program under online tourism business scenarios.FindingsBy providing a framework design about personalized recommendations of online tourism including a flow from data collection to a personalized recommendation algorithm selection, logical analysis is established while the corresponding personalization algorithm is improved.Originality/valueThis study show a logical shift of personalized recommendations in online tourism management from focusing on the simple collection of travel information and the logical speculation of tourism products to focusing on the individual behavior of potential travelers.