bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of febrile seizures in mesial temporal lobe epilepsy with hippocampal sclerosis on gene expression using bioinformatical analysis
Authors: Li Yinchao , Wang Chengzhe , Wang Peiling , Li Xi , Zhou Liemin 
Published: November 2020

AbstractBackgroundTo investigate the effect of long-term febrile convulsions on gene expression in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) and explore the molecular mechanism of MTLE-HS.MethodsMicroarray data of MTLE-HS were obtained from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) between MTLE-HS with and without febrile seizure history were screened by the GEO2R software. Pathway enrichment and gene ontology of the DEGs were analyzed using the DAVID online database and FunRich software. Protein–protein interaction (PPI) networks among DEGs were constructed using the STRING database and analyzed by Cytoscape.ResultsA total of 515 DEGs were identified in MTLE-HS samples with a febrile seizure history compared to MTLE-HS samples without febrile seizure, including 25 down-regulated and 490 up-regulated genes. These DEGs were expressed mostly in plasma membrane and synaptic vesicles. The major molecular functions of those genes were voltage-gated ion channel activity, extracellular ligand-gated ion channel activity and calcium ion binding. The DEGs were mainly involved in biological pathways of cell communication signal transduction and transport. Five genes (SNAP25, SLC32A1, SYN1, GRIN1,andGRIA1) were significantly expressed in the MTLE-HS with prolonged febrile seizures.ConclusionThe pathogenesis of MTLE-HS involves multiple genes, and prolonged febrile seizures could cause differential expression of genes. Thus, investigations of those genes may provide a new perspective into the mechanism of MTLE-HS.
EGFR/ErbB2-Targeting Lapatinib Therapy for Aggressive Prolactinomas
Authors: Cooper Odelia , Bonert Vivien S , Rudnick Jeremy , Pressman Barry D , Lo Janet , Salvatori Roberto , Yuen Kevin C J , Fleseriu Maria , Melmed Shlomo 
Published: November 2020

Abstract

Context
Approximately 10% to 20% of prolactinomas are resistant to dopamine agonist therapy. The ErbB signaling pathway may drive aggressive prolactinoma behavior.

Objective
We evaluated lapatinib, an ErbB1-epidermal growth factor receptor (EGFR)/ErbB2 or human EGFR2 (HER2) tyrosine kinase inhibitor (TKI), in aggressive prolactinomas.

Design
A prospective, phase 2a multicenter trial was conducted.

Setting
This study took place at a tertiary referral pituitary center.

Patients
Study participants included adults with aggressive prolactinomas showing continued tumor growth despite maximally tolerated dopamine agonist therapy.

Intervention
Intervention included oral lapatinib 1250 mg/day for 6 months.

Main Outcome Measures
The primary end point was 40% reduction in any tumor dimension assessed by magnetic resonance imaging at study end; tumor response was assessed by Response Evaluation Criteria in Solid Tumors criteria. Secondary end points included prolactin (PRL) reduction, correlation of response with EGFR/HER2 expression, and safety.

Results
Owing to rigorous inclusion criteria, of 24 planned participants, only 7 consented and 4 were treated. None achieved the primary end point but 3 showed stable disease, including 2 with a 6% increase and 1 with a 16.8% decrease in tumor diameter. PRL response was not always concordant with tumor response, as 2 showed 28% and 59% increases in PRL. The fourth participant had a PRL-secreting carcinoma and withdrew after 3 months of lapatinib because of imaging and PRL progression. EGFR/HER2 expression did not correlate with treatment response. Lapatinib was well tolerated overall, with reversible grade 1 transaminitis in 2 patients, grade 2 rash in 2 patients, and grade 1 asymptomatic bradycardia in 2 patients.

Conclusions
An oral TKI such as lapatinib may be an effective option for a difficult-to-treat patient with an aggressive prolactinoma.
Bone Mineral Density and Turnover After Sleeve Gastrectomy and Gastric Bypass: A Randomized Controlled Trial (Oseberg)
Authors: Hofsø Dag , Hillestad Thor Olav Widerøe , Halvorsen Erling , Fatima Farhat , Johnson Line Kristin , Lindberg Morten , Svanevik Marius , Sandbu Rune , Hjelmesæth Jøran 
Published: November 2020

Abstract

Context
Bariatric surgery, particularly Roux-en-Y gastric bypass (RYGB), is associated with an increased risk of osteoporotic fractures. It is unknown whether RYGB or sleeve gastrectomy (SG) have different effects on bone health.

Objective
To compare changes in bone mineral density and markers of bone turnover 1 year after SG and RYGB.

Design, Setting, Patients, and Interventions
Randomized, triple-blind, single-center trial at a tertiary care center in Norway. The primary outcome was diabetes remission. Patients with severe obesity and type 2 diabetes were randomized and allocated (1:1) to SG or RYGB.

Main Outcome Measures
Changes in areal bone mineral density (aBMD) and bone turnover markers.

Results
Femoral neck, total hip, and lumbar spine aBMD, but not total body aBMD, decreased significantly more after RYGB (n = 44) than after SG (n = 48) (mean [95% confidence interval] between group differences -2.8% [-4.7 to -0.8], -3.0% [-5.0 to -0.9], -4.2% [-6.4 to -2.1], and -0.5% [-1.6 to 0.6], respectively). The increase in procollagen type 1 N-terminal propeptide (P1NP) and C-telopeptide of type I collagen (CTX-1) were approximately 100% higher after RYGB than after SG (between group difference at 1 year, both P &lt; 0.001). The changes in femoral neck, total hip, and lumbar spine aBMDs and the changes in P1NP and CTX-1 were independently associated with the surgical procedure (all P &lt; 0.05) and not weight change.

Conclusions
Roux-en-Y gastric bypass was associated with a greater reduction in aBMD and a greater increase in bone turnover markers compared with SG. This finding could suggest greater skeletal fragility after RYGB.
Adrenal Cushing Syndrome Diagnosed During Pregnancy: Successful Medical Management With Metyrapone
Authors: Azzola Alescia , Eastabrook Genevieve , Matsui Doreen , Berberich Amanda , Tirona Rommel G , Gray Daryl , Gallego Patricia , Van Uum Stan 
Published: November 2020

Abstract
Adrenal Cushing syndrome during pregnancy is rare, and there is limited information on the effect and safety of metyrapone treatment both for mother and fetus. We present a 24-year-old woman diagnosed with adrenal Cushing syndrome at the end of the second trimester. We elected treatment with metyrapone titrated to 250 mg 3 times daily, resulting in good clinical response and maternal serum and saliva cortisol levels in the upper half of the normal pregnancy range. A healthy male infant was born at 35 weeks’ gestation, with no clinical signs of adrenal insufficiency, this despite a low cortisol of 5 nmol/L on the first day of life. We measured metyrapone in maternal and umbilical cord blood samples, demonstrating fetal venous metyrapone levels similar to maternal venous concentration, and a fetal arterial cord concentration at about 60% of the fetal venous cord concentration. This case demonstrates that salivary cortisol levels may be used to monitor the effect of metyrapone on adrenal Cushing syndrome during pregnancy. We show, for the first time in humans, that metyrapone does cross the placenta and may suppress fetal cortisol production without necessarily causing clinical signs of adrenal insufficiency.
A rapid review and meta-analysis of the asymptomatic proportion of PCR-confirmed SARS-CoV-2 infections in community settings
Authors: Beale Sarah , Hayward Andrew , Shallcross Laura , Aldridge Robert W. , Fragaszy Ellen 
Published: November 2020

Background: Cross-sectional studies indicate that up to 80% of active SARS-CoV-2 infections may be asymptomatic. However, accurate estimates of the asymptomatic proportion require systematic detection and follow-up to differentiate between truly asymptomatic and pre-symptomatic cases. We conducted a rapid review and meta-analysis of the asymptomatic proportion of PCR-confirmed SARS-CoV-2 infections based on methodologically appropriate studies in community settings. Methods: We searched Medline and EMBASE for peer-reviewed articles, and BioRxiv and MedRxiv for pre-prints published before 25/08/2020. We included studies based in community settings that involved systematic PCR testing on participants and follow-up symptom monitoring regardless of symptom status. We extracted data on study characteristics, frequencies of PCR-confirmed infections by symptom status, and (if available) cycle threshold/genome copy number values and/or duration of viral shedding by symptom status, and age of asymptomatic versus (pre)symptomatic cases. We computed estimates of the asymptomatic proportion and 95% confidence intervals for each study and overall using random effect meta-analysis. Results: We screened 1138 studies and included 21. The pooled asymptomatic proportion of SARS-CoV-2 infections was 23% (95% CI 16%-30%). When stratified by testing context, the asymptomatic proportion ranged from 6% (95% CI 0-17%) for household contacts to 47% (95% CI 21-75%) for non-outbreak point prevalence surveys with follow-up symptom monitoring. Estimates of viral load and duration of viral shedding appeared to be similar for asymptomatic and symptomatic cases based on available data, though detailed reporting of viral load and natural history of viral shedding by symptom status were limited. Evidence into the relationship between age and symptom status was inconclusive. Conclusion: Asymptomatic viral shedding comprises a substantial minority of SARS-CoV-2 infections when estimated using methodologically appropriate studies. Further investigation into variation in the asymptomatic proportion by testing context, the degree and duration of infectiousness for asymptomatic infections, and demographic predictors of symptom status are warranted.
Staff Satisfaction Management
Authors: Skripnichenko L. 
Published: November 2020

Dynamically changing conditions for the development of society, transformations taking place both in the internal and external environment of the organization, have a significant impact on the processes of personnel management. Each employee contributes to the end result of the enterprise. Employee satisfaction affects the competitiveness of the company, its stability in a crisis, the ability to take a leading position in changes in the market economy. Staff satisfaction is one of the key factors for the stable functioning of the company. The more employees are satisfied with their work space, functional duties, organization, nature and content of work, material and intangible incentives, advancement on the career ladder, labor collective, the more effective their work in the organization will become. Also, among the factors affecting the satisfaction of staff work, one can distinguish the qualification of an employee, his individual characteristics, gender, age, length of service.
The person in the organization acts as the most important resource in which it is necessary to invest a special type of investment in the form of remuneration, providing opportunities for the development and improvement of professional skills, creating comfortable working conditions. The need to understand the mechanisms that drive a person, affect his satisfaction with labor and then encourage him to develop and have led to this study.
Surgical outcomes of full endoscopic spinal surgery for lumbar disc herniation over a 10-year period: A retrospective study
Authors: Chen Chien-Min , Sun Li-Wei , Tseng Chun , Chen Ying-Chieh , Wang Guan-Chyuan 
Published: November 2020

ObjectiveFull endoscopic lumbar discectomy (FELD) for lumbar disc herniation (LDH) has become popular in recent years. Previous studies have proven the efficacy, but few have discussed the possible risk factors of poor outcome. In this study, we reviewed patients who underwent FELD at Changhua Christian Hospital in the past 10 years and sought to identify factors associated with poor surgical outcomes and re-operations.MethodsWe retrospectively reviewed records from mid-2009 to mid-2018. Patients had undergone FELD and follow-up for ≥1 year were included. Factors included in the outcome evaluations were age, sex, surgical time, body mass index, surgical methods, disc herniation type, extension of herniation, degree of canal compromised, disc degenerative grade, smoking and alcohol use, surgical lumbar level, symptom duration, Oswestry low back disability index, and visual analog scale score. We had evolved from inside-out methods to outside-in methods after 2016, thus, we included this factor in the analysis. The primary outcomes of interest were poor/fair MacNab score and re-operation.ResultsFrom mid-2009 to mid-2018, 521 patients met our criteria and were analyzed. The median follow-up was 1685 days (range, 523–3923 days). Thirty-one (6.0%) patients had poor surgical outcomes (fair/poor MacNab score) and 45 (8.6%) patients required re-operation. Prolapsed herniated disc (P< 0.001), higher disc degenerative grade (P= 0.047), higher lumbar level (P= 0.026), longer preoperative symptoms (P< 0.001), and surgery before 2017 (outside-in technique,P= 0.020) were significant factors associated with poor outcomes in univariate analyses. In multivariate analyses, prolapsed herniated disc (P< 0.001), higher disc degenerative grade (P= 0.030), and higher lumbar level (P= 0.046) were statistically significant. The most common adverse symptom was numbness. Factors possibly associated with higher re-operation rate were older age (P= 0.045), alcohol use (P= 0.073) and higher lumbar level (P= 0.069). Only alcohol use showed statistically significant re-operation rates in multivariate analyses (P= 0.035).ConclusionsFor treating LDH by FELD, we concluded that prolapsed disc, higher disc degenerative grade, higher lumbar level, and longer preoperative symptom duration were possibly associated with unsatisfactory surgical outcomes (poor/fair MacNab score). The outside-in technique might be superior to the inside-out technique. Older age and alcohol use might be associated with a higher re-operation rate.
Measuring adverse events following hip arthroplasty surgery using administrative data without relying on ICD-codes
Authors: Magnéli Martin , Unbeck Maria , Rogmark Cecilia , Sköldenberg Olof , Gordon Max 
Published: November 2020

Introduction
Measure and monitor adverse events (AEs) following hip arthroplasty is challenging. The aim of this study was to create a model for measuring AEs after hip arthroplasty using administrative data, such as length of stay and readmissions, with equal or better precision than an ICD-code based model.

Materials and methods
This study included 1 998 patients operated with an acute or elective hip arthroplasty in a national multi-centre study. We collected AEs within 90 days following surgery with retrospective record review. Additional data came from the Swedish Hip Arthroplasty Register, the Swedish National Patient Register and the Swedish National Board of Health and Welfare. We made a 2:1 split of the data into a training and a holdout set. We used the training set to train different machine learning models to predict if a patient had sustained an AE or not. After training and cross-validation we tested the best performing model on the holdout-set. We compared the results with an established ICD-code based measure for AEs.

Results
The best performing model was a logistic regression model with four natural age splines. The variables included in the model were as follows: length of stay at the orthopaedic department, discharge to acute care, age, number of readmissions and ED visits. The sensitivity and specificity for the new model was 23 and 90% for AE within 30 days, compared with 5 and 94% for the ICD-code based model. For AEs within 90 days the sensitivity and specificity were 31% and 89% compared with 16% and 92% for the ICD-code based model.

Conclusion
We conclude that a prediction model for AEs following hip arthroplasty surgery, relying on administrative data without ICD-codes is more accurate than a model based on ICD-codes.
Investigation of culling practices on a dairy farm
Authors: Tóth Violetta , Nagypál Virág , Süli Ágnes , Mikó Edit 
Published: November 2020

Main aim of cattle breeding is to keep cattles with high productivity in production as long as possible. Thus length of productive lifetime can be increased. Culling is a complex decision. During that age, phases of lactation cycle, milk production, reproduction attributes and health stage all have to be taken into account. Optimal timing is important at culling as too early or too late culling results in economic loss. Culling decision is influenced by economic factors as well such as quantity and price of milk, price of culled cow, purchase price and raising cost of heifer. Many heifer have to be settled into production so all heifer which is suitable for reproduction has to be kept for breeding. As a result of this, all heifer that is healthy in context of reproduction biology has to be taken into breeding. Investigations of this study were made on a Hungarian dairy cattle farm. There is untied system on the farm. Cattles are grouped based on production level and stage of lactation. Daily milking number is three. Culling reasons were analysed in the first three lactations. Based on investigated data, 1175 cow were culled during five years which means 235 cows annually. There were differences between culling reasons. Udder health problems were the main reasons of culling. These presented 30% of the total cullings with 348 individuals. Several individuals were culled without fertilisation in the given lactation. The reason of this could be that the cow did not get pregnant again or other diseases and injuries occurred during lactation period. Most diseases occurred in the first 25 days of second lactation.
An Open Online Product Marketplace to Overcome Supply and Demand Chain Inefficiencies in Times of Crisis
Authors: Haapala Karl R. , Kim Kyoung-Yun , Kremer Gül E. Okudan , Kubat Rony , Shilkrot Roy , Sciammarella Federico M. 
Published: November 2020

Abstract
Digital tools for design and manufacturing have led to a new revolution in how products are conceptualized and made. These advancements have led to the democratization of ideation and creation of personalized products, as well as many other innovations. However, the coronavirus disease 2019 (COVID-19) pandemic has exposed a critical flaw in the digital thread: the manufacturing systems of today remain inflexible to rapid changes brought on by emergency and crisis responses. The inefficiencies of this inflexibility caused by disconnects in supply and demand chains have become especially evident. We present a vision for a digital system—an open online product marketplace—that would enable product designers to rapidly connect with capable producers in meeting urgent customer demands. As such, this digital system would facilitate ordering, orchestration, and fulfillment, as well as continuous improvement of manufacturing-as-a-service systems. It would support flexible, sustainable, and resilient supply and demand chains beyond the COVID-19 period by enabling rapid specification matching for tailored or customized products to existing available manufacturing capabilities.
STRUCTURAL PROCEDURЕ MODEL OF STUDENTS' EDUCATIONAL ACTIVITIES MOTIVATION
Authors: Царик Ольга , Рибіна Наталія , Баб’як Жанна 
Published: November 2020

У статті розглянуто модель мотивації навчальної діяльності студентів крізь призму її структури та процесу актуалізації. Авторами визначено теоретико-методичні аспекти формування зазначеної моделі, а також здійснено термінологічний аналіз основних композитів зовнішньої та внутрішньої мотивації; зазначені стратегічні умови реалізації потенціалу студента в процесі професійної підготовки у закладі вищої освіти. У статті доведено, що внутрішня і зовнішня мотивація навчальної діяльності є структурно неоднорідними, що відрізняються за структурою зв'язків з академічними досягненнями і психологічним благополуччям, в основі яких лежать базові психологічні потреби студентів. Водночас, виразність мотиваційних складових навчальної діяльності визначається особливостями освітнього середовища, рівнем її складності, мірою задоволення в ній базових психологічних потреб.
У результаті дослідження було встановлено, що мотивація навчальної діяльності включає свідомі та несвідомі причини, які спонукають людину здійснювати навчальну діяльність, та зроблено висновок, що загалом, оскільки навчальна діяльність є не лише інтелектуальною діяльністю, а й значною мірою соціальною, її оптимально функціонуюча мотивація – це поєднання внутрішніх та продуктивних форм зовнішньої мотивації, де ми приписуємо мотиви, які служать задоволенню основних потреб особистості, з домінуванням внутрішніх виховних мотивів. Автори наголошують, що важливим моментом є те, що здійснення заходів, регульованих внутрішньою мотивацією, дає відчуття радості та щастя, що є ще одним аргументом на користь підтримки внутрішньої навчальної мотивації студентів. Унаслідок здійсненого аналізу було також доведено, що «мотивований» суб'єкт освітньої діяльності має цілу низку когнітивних характеристик, що забезпечують процеси постановки цілей, реалізацію намірів, планування діяльності, реагування на невдачі, прояв наполегливості, в сукупності призводять до високих результатів в виконуваної навчальної діяльності.
ПРАКТИЧНА РЕАЛІЗАЦІЯ ІННОВАЦІЙНИХ ПІДХОДІВ ДО РОЗВИТКУ МОВЛЕННЯ ДІТЕЙ ІЗ ОСОБЛИВИМИ ОСВІТНІМИ ПОТРЕБАМИ В УМОВАХ ІНКЛЮЗІЇ ЗАСОБАМИ УКРАЇНСЬКОЇ ВИШИВАНКИ
Authors: Ленів Зоряна 
Published: November 2020

У статті розглянуто основні аспекти застосування вишивки в інклюзивному навчанні дітей із особливими освітніми потребами: 1) культурно-просвітницький; 2) професійно-реабілітаційний; 3) терапевтично-навчальний. Докладно розкрито третій аспект, який реалізується через вивчення українських вишиванок: видів орнаментів, технік вишивання, кольорів, символів, регіональних особливостей, тощо. Основну увагу акцентовано на практичному використанні вишиванок з метою формування передумов до розвитку писемного мовлення молодших школярів із особливими освітніми потребами у Новій українській школі. В основу міждисциплінарного дослідження покладено передові досягнення закордонної та вітчизняної науки та практики в царині інклюзії, а також логопедії на основі нейропсихологічного підходу до розуміння функціонування писемного мовлення. У фрагментах із авторської методичної системи представлено ігрові прийоми, завдання, вправи для розвитку вищих психічних процесів, графо-моторних навичок, оптико-просторової орієнтації, компонентів мовленнєвої системи: фонетико-фонематичних процесів, лексико-граматичної будови та зв’язного мовлення, які можна інтегрувати як у систему корекційно-розвиткових занять логопеда, так і в роботу вчителя та асистента вчителя на уроках в інклюзивному класі.