bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunocytochemical characteristics of thyrocytes in radioiodine refractory metastases of papillary thyroid cancer
Authors: Zelinskaya A. 
Published: December 2019

Summary. The aim of the work was to carry out an immunocytochemical (ICC) study of thyroid peroxidase (TPO) and thyroglobulin (Tg) expression in the punctates of the radioiodine (RI) refractory and RI uptake metastases of thyroid papillary carcinoma (PTC), on the basis of which it is possible to develop new methods of preoperative prediction of RI resistance and RI therapy efficiency for thyroid papillary carcinoma metastases. Materials and Methods: The ICC research was carried out on a fine needle aspiration biopsy material of 104 metastases that were found after thyroidectomy and RI therapy, i.e. in postoperative period (79 — radioiodine-refractory metastases, 25 — radioiodine-uptake metastases). The ICC analysis of TPO and Tg expression in PTC was performed with the use of monoclonal antibodies against TPO and Tg. Results: RI-refractory (RIRM) and RI-uptake metastases of PTC significantly differ by the percentage of cells expressing TPO and Tg (p < 0.05, and p < 0.05 respectively). The effectiveness of RI therapy was different for patients with different percentages of TPO-positive cells. Conclusion: A statistically significant difference was demonstrated in the expression of TPO in a punctates of RI-resistant and RI-sensitive metastatic TPC, based on which a new method for preoperative prediction of RI resistance and RI therapy efficiency was developed. It was shown that ICC determination of Tg expression in metastases is effective in preoperative monitoring of RI resistance of PTC if the part of Tg-positive cells in punctates is lower than 56%. The comprehensive study of the ICC profile of thyrocytes in RI-uptake metastases punctates allows us to develop a personified approach to prediction, monitoring and therapy of patients with PTC.
Detection of polyamines using immunobiosensor based on zinc oxide nanoparticles
Authors: Prylutskyi M.P. , Starodub M.F. 
Published: December 2019

Summary. Aim: To analyze the performance of biosensor based on nanoparticles of zinc oxide for the detection of spermine and spermidine in solution and in cell culture. Materials and Methods: Zinc oxide nanoparticles were used for preparing biosensor containing antibodies to spermine and spermidine. Polyamine concentration is solutions of spermine and spermidine as well as in lyophilisate of MCF-7 cells was measured by luminescence of the samples excited by laser beam at 380 nm. Results: The minimum concentration for the detection of polyamines in model solutions is 10 ng/ml, and maximum one is 100 ng/ml. A higher level of luminescence intensity of nanoparticles was found during analysis the polyamines in MCF-7 lyophilisate allowing for detecting polyamines at concentrations from 100 cells/ml to 100,000 cells/ml. Conclusions: The proposed biosensor system for determining the level of biogenic polyamines in cell lyophilisate using the optical properties of zinc oxide nanoparticles is promising for further improvement of the methodology and its implementation for detection and measurement of polyamines in biological systems.
Hubungan Pengambilan Keputusan dan Iklim Organisasi terhadap Kinerja Guru Madrasah Tsanawiyah di Kabupaten Tangerang
Authors: Wijiyono Wijiyono 
Published: December 2019

The purpose of this study was to find efforts to improve teacher’s performance, namely decision making, and organizational climate, both individually and jointly. This research used sequential explanatory. The population of this study was 669 Private Madrasah teachers in Tangerang regency, with a sample of 251 teachers made proportional random sampling. Data were collected by questionnaires and statistical analysis were used regression correlation. Results of this study indicated that: (1) there is positive correlation between decision making with teacher performance, with correlation coefficients ry1=0,488 (p<0,01), (2) there is positive correlation between organizational climate with teacher performance, ry2=0,378 (p<0,01),(3) there is positive correlation between decision making, organizational climate together with teacher performance, correlation coefficients ry12=0,779 (p<0,01). This result shows that teacher’s performance can be improved through development of decision making, and organizational climate, both individually and jointly.
Can Color and Spectral Doppler Ultrasound of Breast Cancers Help to Predict the Immunohistochemistry profile?
Authors: Alikhassi Afsaneh , Zamani Nokandeh Soodabeh , Mousavi Kazem , Saffar Hana , Gity Masoumeh , Ahmadinejad Nasrin 
Published: December 2019

Purpose: To determine the relationship between color and spectral Doppler features of breast cancers and their biomarkers.
Patients and Methods: From January 2017 to January 2018, 43 patients with breast cancer were enrolled. Age, existence of color flow in the Doppler ultrasound, color flow pattern, tumor size, and immunohistochemistry (IHC) subtypes were recorded.
Results: Among 43 breast cancer patients, IHC profiles showed that 36 patients were estrogen (ER) positive, 30 patients were progesterone (PR) positive, and 12 patients were human epidermal growth factor receptor 2 (Her2) positive. The prevalence of biomarker groups in this study were as follows: luminal A, 21 patients (48.83%); luminal B, 15 (34.88%); Her 2 amplifier, 2 (4.65%); and triple negative, 5 (11.62%). Thirty-seven patients (86.04%) with malignant masses had detectable flow and six patients (13.95%) had no detectable flow. The ER-positive and PR-positive breast cancers had the highest vascular presence rate in color Doppler ultrasound but it was not statistically significant. Maximum vessel diameter in different biomarker groups and Doppler color patterns with various biomarkers showed no significant differences.
Conclusion: It is not possible to predict breast cancer biomarker groups using available color Doppler features and indexes, so pathology with IHC is still required.
OSMANLI MODERNLEŞMESİN’DE TOPLUM KARŞISINDA ÖZNELEŞMEK; MEKTEB-İ TIBBİYE VE İÇTİMAİ TABİP GELENEĞİ
Authors: VURAL Mithat Kadri 
Published: December 2019

Doğrunun tek olduğu ve bilim sayesinde kolaylıkla elde
edilebildiği bir anlam dünyası içinde Batılılaşma, Osmanlı topraklarında yeni
bir aydın kimliği yaratmakla kalmadı aynı zamanda bu kimliğe yaslandı. Söz
konusu bu yeni zümre özellikle Mekteb-i Tıbbiye’de aldıkları eğitiminin
sonucunda hayat adını verdikleri süreci kimyasal, fiziksel, biyolojik
değişmelere yani “maddi” etmenlere bağlamaktaydı. Pozitivist yaklaşım onlara
doğrusal bir tarih anlayışı vermiş ve toplumun fiziksel bir nesne gibi
incelenebileceği sanısını yaratmıştı. Öte yandan pozitivizm, aydınların toplumu
biçimlendirme çabasına meşruiyet de sağlamaktaydı. Bilimin adım adım ilerlediği
bir dünyada toplumların da bilim takip etmeleriyle bizzat tarih doğrusal bir
hale gelmekteydi. Bunun anlamı bugün ‘geri’ kalmış olan toplumların ancak
‘ileri’ gitmiş olanları taklit ederek, onların geçtiği yoldan ilerlemenin
mümkün olan tek gerçekçi yöntem olduğuydu. “Geri” kalmış toplumlar için modern
bilimin gereğine uygun bir toplum ve yaşam biçimi modeli oluşturmak ve toplumu
biran önce bu kalıp içinde şekillendirmek gereklilik halini almıştı. Bu
doğrultuda ortaya çıkan toplumsal mühendislik faaliyeti öncelikle Mekteb-i
Tıbbiye de karşılık bulacak ve buradan yetişenler modernleşmenin taşıyıcı
haline gelecekti.

Bu çalışma Osmanlı aydınlarının “tarihsel kurtarıcılık”
rolünü oynama iradesini kendi içinde nasıl, hangi koşullarda ve niçin hissettiğini,
“toplumsal dönüştürücülük” rolünü yerine
getirirken hangi yöntemleri izlediklerini ve bütün bunların Mekteb-i
Tıbbiye’deki müfredat ile olan ilişkisi üzerinden anlamayı amaçlamaktadır. Türkiye’de birçok sosyal meselenin tarihçilerin ve
tarih çalışmalarının gündemine girmeden, romanların konusu olduğu gerçeğini de
göz önüne alarak, zengin bir içreğe sahip edebi metinlerin artık daha fazla
başvurulan bir akademik alana dönüştüğü de unutulmamalıdır. Dolayısıyla Türk
modernleşmesinin yarattığı aydın tipini bütün boyutlarıyla anlamak edebi metinlere
de başvurmayı zorunlu hale getirmektedir.
Pelayanan Informasi Obat Pada Kader Puskesmas dan Sosialisasi Bahaya Narkoba Pada Anak Sekolah di Kota Kendari
Authors: Ihsan Sunandar , Sabarudin S , Fitrawan La Ode Muhammad , Nuralifah N , Arba Muhammad , Nurrokhmadhani Wa Ode Sitti 
Published: December 2019

Kegiatan sosialisasi DAGUSIBU (Dapatkan Gunakan Simpan Buang) metode Cara Belajar Insan Aktif/CBIA pada kader Puskesmas Mokoau dan sosialisasi bahaya Narkoba pada siswa sekolah menengah atas di Kota Kendari telah dilaksanakan oleh tim Pengabdian Kepada Masyarakat Fakultas Farmasi UHO. Tujuan dari kegiatan sosialisasi DAGUSIBU metode CBIA adalah untuk meningkatkan pengetahuan masyarakat terkait cara penggunaan obat yang baik dan benar melalui komunitas tertentu di masyarakat, dan sosialisasi Narkoba bertujuan untuk memberi pengetahuan mengenai modus-modus penyebaran Narkoba serta bahaya dan bentuk-bentuk penyalahgunaan obat termasuk Narkoba jenis baru. Kegiatan sosialisasi DAGUSIBU metode CBIA dilakukan pada Kader Puskesmas Mokoau berjumlah 22 orang dibagi dalam 4 kelompok dipandu oleh Master AoC Gema Cermat Kemenkes RI utusan Kota Kendari. Tahap, pertama pemberian penjelasan umum tentang Gerakan Masyarakat Cerdas Menggunakan Obat/GEMA CERMAT dan DAGUSBU, kedua tiap peserta diberikan kuisioner pretest untuk mengetahui tingkat pengetahuan peserta sebelum sosialisasi. Kegiatan inti adalah peserta mengelompokkan obat-obat yang diberikan dalam formulir yang telah dibagikan berdasarkan kandungan zat aktif untuk di identifikasi nama dagang, indikasi, efek samping dan kontraindikasi yang ada pada kemasan obat dengan di fasilitasi oleh seorang Apoteker. Kegiatan akhir adalah peserta mempresentasikan hasil diskusi salah satunya tentang tidak ada perbedaan antara obat generik dan bermerek pada kualitas dan efektivitasnya untuk indikasi penyakit yang sama. Selain itu pada cara penyimpanan harus sesuai bentuk sediaan obat dan pemusnahan obat yang di pisahkan dari kemasan primernya dengan cara ditanam dalam tanah. Posttest dilakukan untuk menilai tingkat pengetahuan setelah kegiatan. Sosialisasi Narkoba dilakukan di dilakukan di SMA 1 Kendari oleh 3 orang peserta 207 orang, SMA 4 Kendari oleh 4 orang apoteker dengan jumlah peserta 1669 orang, SMA 9 Kendari oleh 3 orang apoteker dengan jumlah peserta 916 orang, SMK 2 Kendari oleh 3 orang apoteker dengan jumlah peserta 324 orang dan SMK 4 Kendari oleh 3 Apoteker dengan jumlah peserta 579 orang. Kegiatan tersebut bekerjasama dengan Pengurus Daerah Ikatan Apoteker Indonesia Sulawesi Tenggara dan Badan Narkotika Nasional Provinsi Sulawesi Tenggara. Kata kunci: Dagusibu, CBIA, Narkoba, Gema Cermat, Farmasi, Halu Oleo
Aktivitas Antimikroba Ekstrak Etanol dan Fraksi Organik Rimpang Wualae (Etlingera elatior (Jack) R.M. Smith)
Authors: Musnina Wa Ode Sitti , Wahyuni W , Malik Fadhliyah , Timung Yusni Oktaviani , Sabandar Carla Wulandari 
Published: December 2019

Wualae (Etlingera elatior (Jack) R.M Smith) merupakan tanaman rempah yang digunakan oleh masyarakat sebagai obat tradisional. Penelitian ini bertujuan untuk mengetahui metabolit sekunder, aktivitas antibakteri dan aktivitas antijamur ekstrak etanol dan fraksi organik rimpang wualae. Rimpang wualae diekstraksi dengan metode maserasi menggunakan etanol kemudian di fraksinansi menggunakan pelarut n-heksana, etil asetat, dan metanol. Fraksi n-heksana, etil asetat, dan metanol diuji secara in vitro dengan metode Cup-plate technique, yang dilakukan terhadap bakteri Gram positif Staphylococcus aureus ATCC 25923, Bacillus subtilis FNCC 0060 dan Streptococcus mutans ATCC 2517 dan bakteri Gram negatif Escherichia coli ATCC 35218, Pseudomonas aeruginosa, Salmonella enteric dan jamur Candida albicans ATCC 10231. Kandungan senyawa metabolit sekunder rimpang wualae ditentukan dengan metode skrining fitokima menggunakan perekasi warna. Hasil skrining fitokimia ekstrak etanol fraksi n-heksana, etil asetat, metanol dan etanol rimpang wualae memiliki kandungan alkaloid, flavonoid, saponin, tannin dan terpenoid. Ekstrak etanol mengandung alkaloid, flavonoid, saponin, tannin, dan terpenoid, fraksi n-heksana mengandung terpenoid, fraksi etil asetat mengandung flavonoid, tannin dan terpenoid, fraksi metanol mengandung alkaloid, saponin, tannin, fraksi etanol mengandung flavonoid, saponin, tannin, dan terpenoid. Hasil pengujian aktivitas antibakteri menunjukkan bahwa ekstrak etanol, fraksi n-heksana, etil asetat, metanol dan etanol rimpang wualae tidak aktif terhadap bakteri S. aureus, B. subtilis, S. mutans, E. coli, P, aeruginosa dan S. enterica pada konsentrasi 100-12,5 mg/mL. Pengujian antijamur menunjukkan bahwa fraksi etil asetat aktif terhadap jamur C. albicans pada konsentrasi 100, 50, 25, dan 12,5 mg/mL dengan nilai DDH masing-masing sebesar nilai 9,75; 9,5; 8,75; dan 8 mmKata kunci: wualae, Etlingera, antimikroba, obat tradisional, Sulawesi TenggaraJurusan Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako, Jl. Soekarno Hatta Km. 9 Palu
Kajian Etnomedisin Tumbuhan Obat Tradisional Suku Muna Desa Oe Nsuli Kecamatan Kabangka Kabupaten Muna Sulawesi Tenggara
Authors: Kasmawati Henny , Ihsan Sunandar , Suprianti Rani 
Published: December 2019

Studi etnomedisin tumbuhan obat pada suku Muna telah dilakukan dari Bulan September sampai Februari 2019 di desa Oe Nsuli Kecamatan Kabangka, Kabupaten Muna Sulawesi Tenggara. Penelitian ini bertujuan untuk mengetahui berbagai spesies dan organ tumbuhan yang dimanfaatkan, cara pengolahan, cara pemberian, takaran, khasiat dan makna filosofis penggunaan tumbuhan obat oleh masyarakat suku Muna di desa Oe Nsuli. Jenis penelitian ini adalah penelitian deskriptif observasional yang menggunakan metode kualitatif dan teknik pengambilan sampel yaitu purpossive sampling melalui wawancara open-ended dengan 2 informan yang menggunakan pedoman wawancara. Berdasarkan hasil penelitian ditemukan sebanyak 31 spesies tumbuhan yang terbagi dalam 24 famili yang telah dimanfaatkan sebagai obat. Organ tumbuhan yang dimanfaatkan antara lain daun, batang, akar, rimpang, herba dan biji. Cara pengolahannya yaitu direbus, dikunyah, dimemarkan, ditumbuk, diparut, dikonsumsi secara langsung, diperas, direndam dan diembunkan. Makna filosofis yang terkandung pada penggunaan obat tradisional masyarakat suku Muna didesa Oe Nsuli terkait erat dengan nilai filosofis spiritual yang dianut oleh masyarakat suku Muna sebagai penganut agama Islam yang bercorak tasawuf dan membentuk sebagian besar budaya dalam masyarakat Muna.Kata kunci: Etnomedisin, tanaman obat, obat tradisional, Suku Muna
Національна ідея як чинник формування національної ідентичності України
Authors: Пасічник В. М. 
Published: December 2019

Розглянуто особливості формування української національної ідентичності. Виявлено розмитість та амбівалентність національної ідентичності України на сучасному етапі її розвитку. Проаналізовано причини, що гальмують процеси завершення формування української нації. Обґрунтовано роль національної ідеї як чинника формування української національної ідентичності.
Удосконалення механізму державного регулювання ринку надання послуг з інкасації коштів та перевезень валютних цінностей в Україні
Authors: Федець А. В. 
Published: December 2019

Обґрунтовано необхідність удосконалення механізму державного регулювання ринку надання послуг з інкасації коштів та перевезень валютних цінностей в Україні, зокрема підвищення вимог до умов видачі Національним банком України юридичним особам ліцензії на надання банкам послуг з інкасації та посилення контролю за їх діяльністю. З метою невідкладного реагування на наявні і потенційні загрози національним інтересам, національній безпеці України, в умовах постійного зменшення кількості банківських установ в Україні, що мають власні підрозділи інкасації та перевезення цінностей, наявності ризиків зміни форми власності державних уповноважених банків, збереження державного впливу на ринок надання послуг з інкасації коштів і перевезень валютних цінностей в Україні та механізмів його регулювання, запропоновано трансформувати систему грошового обігу Національного банку України в частині створення альтернативної схеми готівкового обігу Національного банку України та здійснення перевезень валютних цінностей в системі Національного банку України винятково силами підрозділів перевезення цінностей Національного банку України. Порушено питання щодо відновлення статусу державних службовців окремим категоріям працівників Національного банку України та створення єдиного сертифікованого центру професійної підготовки та підвищення кваліфікації інкасаторів та водіїв.
PERUBAHAN KEBIJAKAN LUAR NEGERI INDONESIA TERHADAP ISU NUKLIR IRAN DI DEWAN KEAMANAN PBB TAHUN 2007-2008
Authors: Setiawan Asep 
Published: December 2019

This study is aimed to analyze Indonesia’s foreign policy changes toward Iranian nuclear issue in The United Nations Security Council (UNSC) from 2007 to 2008. The Iranian nuclear issue became international focus when UNSC in 2006 decided the future of Iranian nuclear program. Nuclear proliferation’s threat was debated in UNSC due to a new nuclear program launched by Iranian President Mahmoud Ahmadinejad to build nuclear arsenal as soon as possible. As a non-permanent member of UNSC, Indonesia should participate in any decision within two years whether to support, abstain or to reject any resolutions decided.
The research used qualitative method with a case study type. Data was collected based on qualitative method through literature study and interviews in order to gain understanding why the changes occurred in Indonesia’s foreign policy with domestic and international factors as consideration.
The research concluded that Indonesia’s foreign police changes was on international pressure to support new sanction on Iranian nuclear program in 2007. Indonesia’s policy was criticized in domestic. After domestic pressure, Indonesia finally took abstain policy in a new resolution on Iran nuclear in UNSC on March 2008. In other words the Indonesian foreign policy changes can be classified in adjustment changes to appease domestic pressure and in the same time to avoid confrontation with major powers interests.
Sederek ve Şerur İli (Nahçıvan Özerk Cümhuriyeti/Azerbaycan) Florası ve Vejetasyonuna Katkılar
Authors: CABBAROV Musa , IBRAHİMOV Elyar , NABİYEVA Fatmaxanım , ATAMOV Vagif 
Published: December 2019

Makalede Azerbaycan’a bağlı Nahçıvan Özerk Cumhuriyeti’nin
Sederek ve Şerur İl sınırları içerisindeyer alan bölgeninflora ve vejetasyonuele
alınmıştır. Bölgede hakim olan frigana vejetasyonunda karakteristik olanbazı bitkiler
meyve verimliliği yönünden araştırılmıştır.Bitki örtüsünde bazı faydalı bitki
türlerinin bol yayılış gösterdiği ve rasyonel kullanım imkanlarının olduğu
belirlenmiştir. Arazi çalışmaları sırasında toplanan bitki örnekleriiçerisinde:Pyrus
salicifolia Pall.,Malus orientalis var. montana (Uglitzk.) Langenf, Pistacia
mutica Fisch. &amp;
C.A. Mey., Amigdalus
fenzliana (Fritsch) Lipsky, Lonicera
bracteolaris Boiss. et Buhse, Rhamnus
catharicus L. Prunus spinosa L. Amelenchier
ovalis Medik., Ziziphus jujuba Mill., Asperunginoides axillaris (Boiss.et
Hohen) Rauschert, Centranthus longifolius
Stev., Ribes nigrum L., Helosciadium nodiflorum (L.) W.D. J.
Koch.vd. taksonlarında araştırma alanı içerisinde yayılış gösterdiği belirlenmiştir.
Some Properties of Fiberboard Manufactured with Wastes of Kraft Pulp Mill
Authors: USTAÖMER Derya , ERSOY KALYONCU Evren , KIRCI Hüseyin 
Published: December 2019

In this study, it was aimed to investigate the usability of some wastes
such as wood chip screening rejects and kraft pulp screening rejects as fibrous
materials in the manufacture of medium density fiberboard (MDF). Chip screening rejects were refined with a laboratory type refiner;
however, pulp screening rejects were not refined. These materials
were added to commercial fibers with the rates of 10%, 30%. Fiberboards were
manufactured using urea formaldehyde (UF) adhesive. Some properties of these
fiberboards such as water absorption (WA), thickness swelling (TS), surface
roughness parameters, color change, modulus of rupture (MOR) and modulus of
elasticity (MOE) values were determined. As a result of these, it was found
that all values showed different trend depending on rates and types of Kraft
mill wastes. Generally, the use of these
materials had positive effects on the panel properties.
Investigasi Akuifer Air Tanah di Banua Buha Asri 1 Kelurahan Buha Manado Dengan Menggunakan Metode Geolistrik Resistivitas
Authors: As'ari As'ari , Tongkukut Seni Herlina J , Pogaga Brayen A.M , Akasi Iftita A , Sagai Fingken S , Loupatty Thessalonica B 
Published: December 2019

Investigasi Akuifer Air Tanah di Banua Buha Asri 1 Kelurahan Buha Manado Dengan Menggunakan Metode Geolistrik Resistivitas ABSTRAKPenelitian investigasi akuifer air tanah di perumahan Banua Buha Asri 1 Kelurahan Buha dengan menggunakan metode geolistrik resistivitas bertujuan untuk membuat peta model 2 dimensi sebaran air tanah di bawah permukaan. Penyebaran air tanah yang tidak merata menimbulkan masalah bagi masyarakat dalam memenuhi kebutuhan hidupnya. Keberadaan air tanah yang tersimpan dalam akuifer, dapat diidentifikasi dengan menggunakan eksplorasi geofisika. Metode geolistrik konfigurasi dipol-dipol cocok digunakan sebagai metode untuk identifikasi akuifer air tanah. Data pengukuran diolah menggunakan perangkat lunak Res2Dinv. Eksplorasi menghasilkan peta model 2 dimensi tampang lintang resistivitas bawah permukaan. Akuifer air tanah potensial teridentifikasi mempunyai resistivitas ρ ≤ 24 Ωm dengan kedalaman ≤ 8 m pada lintasan 1 dan ≤ 12 m berada pada lintasan 2. Air tanah dalam teridentifikasi pada kedalaman ≥ 20 m pada kedua lintasan.Kata Kunci: akuifer, geolistrik, resistivitasGroundwater Aquifer Investigation in Banua Buha Asri 1 Buha Village Manado by Using Resistivity Geoelectric Method ABSTRACTResearch on groundwater aquifer investigation in Banua Buha Asri 1 housing Buha Village by using resistivity geoelectric method goals to create a 2-dimensional model map of subsurface groundwater distribution. The uneven distribution of ground water causes problems for the community to fullfil their daily needs, because almost all human activities in their daily needs intersect with water. The presence of ground water stored in aquifers can be identified using geophysical exploration. The dipole-dipole configuration of geoelectric method is suitable as a method for identifying groundwater aquifers. Measured data processed by using Res2Dinv software. Exploration produced a 2-dimensional map of subsurface resistivity cross-sectional models. Potential groundwater aquifer (resistivity ρ ≤ 24 Ωm) surface with a depth of ≤ 8 m on line 1 and ≤ 12 m on line 2. Deep ground water was identified at a depth of ≥20 m on both lines.Keywords: aquifer, geoelectric, resistivity