bluuebunny/crossref_metadata_2025_split huggingface dataset:
In utero heat stress alters the postnatal innate immune response of pigs
Authors: Johnson Jay S , Maskal Jacob M , Duttlinger Alan W , Kpodo Kouassi R , McConn Betty R , Byrd Christopher J , Richert Brian T , Marchant-Forde Jeremy N , Lay Donald C , Perry Shelbi D , Lucy Matthew C , Safranski Tim J 
Published: November 2020

Abstract
The effects of in utero heat stress (IUHS) range from decreased growth performance to altered behavior, but the long-term impact of IUHS on postnatal innate immune function in pigs is unknown. Therefore, the study objective was to determine the effects of early gestation IUHS on the immune, metabolic, and stress response of pigs subjected to an 8 hr lipopolysaccharide (LPS) challenge during postnatal life. Twenty-four pregnant gilts were exposed to thermoneutral (TN; n = 12; 17.5 ± 2.1 °C) or heat stress (HS; n = 12; cyclic 26 to 36 °C) conditions from days 6 to 59 of gestation, and then TN conditions (20.9 ± 2.3 °C) from day 60 of gestation to farrowing. At 12 wk of age, 16 IUHS and 16 in utero thermoneutral (IUTN) pigs were selected, balanced by sex and given an intravenous injection of LPS (2 µg/kg BW mixed with sterile saline [SAL] and injected at 2 µL/kg BW) or SAL (2 µL/kg BW). Body temperature was monitored every 30 min, and blood was obtained at 0, 1, 2, 3, 4, 6, and 8 hr following the LPS challenge. Blood samples were analyzed for glucose, insulin, non-esterified fatty acids (NEFA), cortisol, and cytokine concentrations. In addition, white blood cell counts were determined at 0 and 4 hr. Hour 0 data were used as covariates. Body temperature was increased (P &lt; 0.01) in LPS (40.88 ± 0.08 °C) vs. SAL (39.83 ± 0.08 °C) pigs. Eosinophils tended to be decreased overall (P = 0.09; 43.9%) in IUHS vs. IUTN pigs. Glucose concentrations were reduced overall (P = 0.05; 5.9%) in IUHS vs. IUTN pigs. The NEFA concentrations tended to be greater (P = 0.07; 143.4%) in IUHS-LPS pigs compared with all other treatments, and IUTN-LPS pigs tended to have greater (127.4%) circulating NEFA concentrations compared with IUTN-SAL and IUHS-SAL pigs. Cortisol was increased (P = 0.04) in IUHS-LPS compared with IUTN-LPS pigs at 3 hr (21.5%) and 4 hr (64.3%). At 1 hr, tumor necrosis factor α was increased (P = 0.01; 115.1%) in IUHS-LPS compared with IUTN-LPS pigs. Overall, interleukin-1β (IL-1β) and interleukin-6 (IL-6) were greater (P &lt; 0.04; 281.3% and 297.8%, respectively) in IUHS-LPS pigs compared with all other treatments, and IUTN-LPS pigs had increased IL-1β and IL-6 concentrations compared with IUTN-SAL and IUHS-SAL pigs. In summary, IUHS altered the postnatal cytokine, metabolic, and physiological stress response of pigs during postnatal life, which may have negative implications toward the innate immune response of IUHS pigs to pathogens.
A dynamic actin-dependent nucleoskeleton and cell identity
Authors: Venit Tomas , El Said Nadine Hosny , Mahmood Syed Raza , Percipalle Piergiorgio 
Published: November 2020

AbstractActin is an essential regulator of cellular functions. In the eukaryotic cell nucleus, actin regulates chromatin as a bona fide component of chromatin remodelling complexes, it associates with nuclear RNA polymerases to regulate transcription and is involved in co-transcriptional assembly of nascent RNAs into ribonucleoprotein complexes. Actin dynamics are, therefore, emerging as a major regulatory factor affecting diverse cellular processes. Importantly, the involvement of actin dynamics in nuclear functions is redefining the concept of nucleoskeleton from a rigid scaffold to a dynamic entity that is likely linked to the three-dimensional organization of the nuclear genome. In this review, we discuss how nuclear actin, by regulating chromatin structure through phase separation may contribute to the architecture of the nuclear genome during cell differentiation and facilitate the expression of specific gene programs. We focus specifically on mitochondrial genes and how their dysregulation in the absence of actin raises important questions about the role of cytoskeletal proteins in regulating chromatin structure. The discovery of a novel pool of mitochondrial actin that serves as ‘mitoskeleton’ to facilitate organization of mtDNA supports a general role for actin in genome architecture and a possible function of distinct actin pools in the communication between nucleus and mitochondria.
Environmental processing of galaxies in H i-rich groups
Authors: Džudžar Robert , Kilborn Virginia , Sweet Sarah M , Meurer Gerhardt , Jarrett T H , Kleiner Dane 
Published: November 2020

ABSTRACT
We present and explore the resolved atomic hydrogen (H i) content of 13 H i-rich and late-type dominated groups denoted ‘Choirs’. We quantify the H i content of the Choir galaxies with respect to the median of the H i-mass fraction ($f_{\rm{{H {\small I}}}}$) of their grandparent H i Parkes All Sky Survey (HIPASS) sample. We find that the H i-mass fraction of the Choir galaxies is dispersed around the HIPASS median in the range $-1.4\le \Delta f_{\rm{{H {\small I}}}}\textrm{[dex]}\le$ 0.7, from H i-excess to H i-deficient galaxy regime. The H i-excess/H i-deficient galaxies contain more/less than 2.5 times their expected H i content with respect to the HIPASS median. We show and discuss that the environmental processing in Choirs occurs via tidal stripping and galaxy mergers. Our analysis suggests that tidal stripping contributes to the loss of the H i, while galaxy mergers contribute to the enhancement of the H i. Exploring the mid-infrared properties of Choir galaxies, we find possible environmental processing in only nine Choir galaxies, which indicates that environmental processing is more perceptible in the H i content than the mid-infrared properties. Moreover, we find that environmental processing occurs in Choir groups regardless of their global environment, whether they are in isolation or in proximity to the denser structures, such as cosmic web filaments. We explore possible scenarios of the Choirs evolution, taking into account their H i content, velocity dispersion, crossing time, and their global environment. We conclude that the most likely evolution for the majority of Choir groups is that they will become more compact as their members undergo multiple H i-rich mergers.
Life after eruption VIII: The orbital periods of novae
Authors: Fuentes-Morales I , Tappert C , Zorotovic M , Vogt N , Puebla E C , Schreiber M R , Ederoclite A , Schmidtobreick L 
Published: November 2020

ABSTRACT
The impact of nova eruptions on the long-term evolution of Cataclysmic Variables (CVs) is one of the least understood and intensively discussed topics in the field. A crucial ingredient to improve with this would be to establish a large sample of post-novae with known properties, starting with the most easily accessible one, the orbital period. Here we report new orbital periods for six faint novae: X Cir (3.71 h), IL Nor (1.62 h), DY Pup (3.35 h), V363 Sgr (3.03 h), V2572 Sgr (3.75 h), and CQ Vel (2.7 h). We furthermore revise the periods for the old novae OY Ara, RS Car, V365 Car, V849 Oph, V728 Sco, WY Sge, XX Tau, and RW UMi. Using these new data and critically reviewing the trustworthiness of reported orbital periods of old novae in the literature, we establish an updated period distribution. We employ a binary-star evolution code to calculate a theoretical period distribution using both an empirical and the classical prescription for consequential angular momentum loss. In comparison with the observational data we find that both models especially fail to reproduce the peak in the 3–4 h range, suggesting that the angular momentum loss for CVs above the period gap is not totally understood.
Developmental remodelling of non-CG methylation at satellite DNA repeats
Authors: Ross Samuel E , Angeloni Allegra , Geng Fan-Suo , de Mendoza Alex , Bogdanovic Ozren 
Published: November 2020

AbstractIn vertebrates, DNA methylation predominantly occurs at CG dinucleotides however, widespread non-CG methylation (mCH) has been reported in mammalian embryonic stem cells and in the brain. In mammals, mCH is found at CAC trinucleotides in the nervous system, where it is associated with transcriptional repression, and at CAG trinucleotides in embryonic stem cells, where it positively correlates with transcription. Moreover, CAC methylation appears to be a conserved feature of adult vertebrate brains. Unlike any of those methylation signatures, here we describe a novel form of mCH that occurs in the TGCT context within zebrafish mosaic satellite repeats. TGCT methylation is inherited from both male and female gametes, remodelled during mid-blastula transition, and re-established during gastrulation in all embryonic layers. Moreover, we identify DNA methyltransferase 3ba (Dnmt3ba) as the primary enzyme responsible for the deposition of this mCH mark. Finally, we observe that TGCT-methylated repeats are specifically associated with H3K9me3-marked heterochromatin suggestive of a functional interplay between these two gene-regulatory marks. Altogether, this work provides insight into a novel form of vertebrate mCH and highlights the substrate diversity of vertebrate DNA methyltransferases.
Rheology of Liquid-Crystalline Polymers
Authors: Han Chang Dae 
Published: November 2020

Abstract
Liquid crystals (LCs) may be divided into two subgroups: (1) lyotropic LCs, formed by mixing rigid rodlike molecules with a solvent, and (2) thermotropic LCs, formed by heating. One finds in the literature such terms as mesomorphs, mesoforms, mesomorphic states, and anisotropic liquids. The molecules in LCs have an orderly arrangement, and different orders of structures (nematic, smectic, or cholesteric structure) have been observed, as schematically shown in Figure 9.1. The kinds of molecules that form LCs generally possess certain common molecular features. The structural characteristics that determine the type of mesomorphism exhibited by various molecules have been reviewed. At present, our understanding of polymeric liquid crystals, often referred to as liquid-crystalline polymers (LCPs), is largely derived from studies of monomeric liquid crystals. However, LCPs may exhibit intrinsic differences from their monomeric counterparts because of the concatenation of monomers to form the chainlike macromolecules. The linkage of monomers inevitably means a loss of their translational and orientational independence, which in turn profoundly affects the dynamics of polymers in the liquid state. These intramolecular structural constraints are expressed in the flexibility of the polymer chain. Generally speaking, the chemical constitution of the monomer determines the flexibility and equilibrium dimensions of the polymer chain (Gray 1962). Figure 9.2 illustrates the variability of chain conformation (flexible chain, semiflexible chain, and rigid rodlike chain) forming macromolecules. Across this spectrum of chain flexibility, the persistence in the orientation of successive monomer units varies from the extreme of random orientation (flexible chains) to perfect order (the rigid rod). Hence, efforts have been made to synthesize LCPs that consist of rigid segments contributing to the formation of a mesophase and flexible segments contributing to the mobility of the entire macromolecule in the liquid state (Ober et al. 1984). From the point of view of molecular architecture, as schematically shown in Figure 9.3, two types of LCP have been developed: (1) main-chain LCPs (MCLCPs), having the monomeric liquid crystals (i.e., mesogenic group) in the main chain of flexible links, and (2) side-chain LCPs (SCLCPs), having the monomeric liquid crystals attached, as a pendent side chain, to the main chain.
On Computable Numbers, with an Application to the Entscheidungsproblem (1936)
Authors: Turing Alan 
Published: November 2020

Abstract
The ‘‘computable’’ numbers may be described briefly as the real numbers whose expressions as a decimal are calculable by finite means. Although the subject of this paper is ostensibly the computable numbers, it is almost equally easy to define and investigate computable functions of an integral variable or a real or computable variable, computable predicates, and so forth. The fundamental problems involved are, however, the same in each case, and I have chosen the computable numbers for explicit treatment as involving the least cumbrous technique. I hope shortly to give an account of the relations of the computable numbers, functions, and so forth to one another. This will include a development of the theory of functions of a real variable expressed in terms of computable numbers. According to my definition, a number is computable if its decimal can be written down by a machine. In §§ 9, 10 I give some arguments with the intention of showing that the computable numbers include all numbers which could naturally be regarded as computable. In particular, I show that certain large classes of numbers are computable. They include, for instance, the real parts of all algebraic numbers, the real parts of the zeros of the Bessel functions, the numbers π, e, etc. The computable numbers do not, however, include all definable numbers, and an example is given of a definable number which is not computable. Although the class of computable numbers is so great, and in many ways similar to the class of real numbers, it is nevertheless enumerable. In § 8 I examine certain arguments which would seem to prove the contrary. By the correct application of one of these arguments, conclusions are reached which are superficially similar to those of Gödel. These results have valuable applications. In particular, it is shown (§ 11) that the Hilbertian Entscheidungsproblem can have no solution. In a recent paper Alonzo Church has introduced an idea of ‘‘effective calculability’’, which is equivalent to my ‘‘computability’’, but is very differently defined. Church also reaches similar conclusions about the Entscheidungsproblem.
Introduction to the dental surgery
Authors: Blinkhorn A S , Chadwick B L 
Published: November 2020

Abstract
It is a common belief among many individuals that being ‘good with people’ is something you are born with and cannot be taught. It is true that some individuals have a more open disposition and can relate well to others. However, everyone can adopt approaches that put children and parents at ease. It is particularly important for dentists to learn how to help people relax, as failure to empathize and communicate will result in disappointed patients and an unsuccessful practising career. Communicating effectively with children is of great value, as ‘being good with younger patients’ is a practice-builder and can reduce the stress involved when offering clinical care. All dental training should include a thorough understanding of how children relate to an adult world, how the dental visit should be structured, and what strategies are available to help children cope with their apprehension about dental procedures. This Chapter will consider these items, beginning with a discussion on the theories of psychological development and following this up with sections on parents and their influence on dental treatment, dentist–patient relationships, anxious and uncooperative children, and helping anxious patients to cope with dental care. The psychological development of children was originally viewed as a series of well-defined phases, but is now seen as a continuum. The phases of development may well differ from child to child, so cannot be rigidly applied, but for clarity are described as a series of psychological developmental milestones from infancy to adulthood. The most important theoretical perspective now influencing thinking about child development is John Bowlby’s attachment theory. Bowlby suggested that child development could best be understood within the framework of patterns of interaction between the infant and the primary caregiver. If there were problems in this interaction, the child was likely to develop insecure and/or anxious patterns that would affect the ability to form stable relationships with others, to develop a sense of self-worth, and to move towards independence. The other important concept to note is that development is a lifelong process—we do not switch off at 18—nor is it an even process. Development is uneven, influenced by periods of rapid bodily change.
Bad Data
Authors: Smith Gary 
Published: November 2020

Abstract
When I first started teaching economics in 1971, my wife’s grandfather (“Popsie”) knew that my Ph.D. thesis used Yale’s big computer to estimate an extremely complicated economic model. Popsie had bought and sold stocks successfully for decades. He even had his own desk at his broker’s office where he could trade gossip and stocks. Nonetheless, he wanted advice from a 21-year-old kid who had no money and had never bought a single share of stock in his life—me—because I worked with computers. “Ask the computer what it thinks of Schlumberger.” “Ask the computer what it thinks of GE.” This naive belief that computers are infallible has been around ever since the first computer was invented more than 100 years ago by Charles Babbage. While a teenager, the great French mathematician Blaise Pascal built a mechanical calculator called the Arithmetique to help his father, a French tax collector. The Arithmetique was a box with visible dials connected to gears hidden inside the box. Each dial had ten digits labeled 0 through 9.When the dial for the 1s column moved from 9 to 0, the dial for the 10s column moved up 1 notch; when the dial for the 10s column moved from9 to 0, the dial for the 100s column moved up 1 notch; and so on. The Aritmatique could do addition and subtraction, but the dials had to be turned by hand. Babbage realized that he could convert complex formulas into simple addition-and-subtraction calculations and automate the calculations, so that a mechanical computer would do the calculations perfectly every time, thereby eliminating human error. Babbage’s first design was called the Difference Engine, a steam powered behemoth made of brass and iron that was 8 feet tall, weighed 15 tons, had 25,000 parts. The Difference Engine could make calculations up to 20 decimals long and it could print formatted tables of results. After a decade tinkering with the design, Babbage began working on plans for a more powerful calculator he called the Analytical Engine. This design had more than 50,000 components, used perforated cards to input instructions and data, and could store up to one thousand 50-digit numbers.
Beat the Market I
Authors: Smith Gary 
Published: November 2020

Abstract
Back when scam artists sent snail-mail instead of e-mail, I received a letter that began “Dear friend,” a clear sign it was from someone trying to sell me something. Nonetheless, I read a bit more and saw this line highlighted in yellow: “IMAGINE turning $1,000 into $34,500 in less than one year!” Real friends don’t highlight their sentences, but I pushed on, thinking I might share this BS with my students. Sure enough, it was a con. The letter said that “no special background or education” was needed and that, “It’s an investment you can make with spare cash that you might ordinarily spend on lottery tickets or the race track.”Now I wasn’t sure that I wanted to share this letter, lest my students wonder where this company had gotten my name. I don’t buy lottery tickets or bet on horses. What had I done that made this company think I was a sucker? The letter claimed that, instead of wasting my money on lottery tickets and horse races, I could get rich buying low-priced stocks. For example, the price of LKA International had jumped from 2 cents a share to 69 cents a share in a few months, which would have turned $1,000 into $34,500. All I had to do was pay $39 for a special report that would give me access to “the carefully guarded territory of a few shrewd ‘inner circle’ investors.” The entire premise is ridiculous. If someone really knew how to turn $1,000 into $34,500, they would be doing it, instead of selling special reports for $39. Yet, we repeatedly fall for such scams because we are hard-wired to think that the world is governed by regular laws that we can discover and exploit. Stock prices cannot be random. There must be underlying patterns, like night and day, winter and summer. Our gullibility is aided and abetted by our greed—by the notion that it is easier to make money by buying and selling stocks than by being a butcher, baker, or candlestick maker. The inconvenient truth is that zigs and zags in stock prices are mostly random, yet transitory patterns can be found in random numbers. If we look for them, we will find them and be fooled by them.
Oral and maxillofacial surgery
Authors: Longridge Nicholas , Clarke Pete , Aftab Raheel , Ali Tariq 
Published: November 2020

Abstract
Oral and facial surgery has been practised in some form for millennia. Hippocrates himself has described reducing jaw dislocations, and Sushtra was performing reconstructive local facial flaps in India as early as sixth century BC. The modern practice of oral and maxillofacial surgery (OMFS) can be traced back to the battlefields of northern Europe in the early twentieth century. Industrialized warfare produced horrific facial injuries that were treated by frontline oral surgeons, and so the specialty of OMFS, as a crossover between medicine and dentistry, developed. It became evi­dent that both medical and dental education was necessary in order to manage increasingly complex facial surgery that was being undertaken. It can be argued that OMFS has evolved to be a truly general surgical specialty, manipulating the hard and soft tissues of the head and neck and having the skills to operate on neurovascular, glandular, and airway struc­tures. There is variable exposure to OMFS during dental undergraduate education and scarce exposure during medical undergraduate training. Opportunities for postgraduate training in OMFS for dentists who are not entertaining a career in the discipline are also limited. Knowledge of the scope of OMFS practice is a bare minimum for any practising dentist, as this can inform the limits of their individual competency, as well as ensure a safe transfer of care for their patients. The questions in this section are there to target the most commonly tested and encountered aspects of OMFS for most junior dentists, focusing on oral surgery, oral pathology, management of the medically compromised patient, and trauma of the facial skeleton. OMFS is an enormously satisfying endeavour and is recommended to all junior dentists. It can form a granite-like foundation of skills upon which to build a career in clinical dentistry. Key topics include: ● Trauma ● Oral surgery and exodontia ● Oral pathology ● Orthognathic surgery ● Temporomandibular joint surgery ● Cleft lip/ palate repair ● Craniofacial surgery ● Salivary disease ● Head and neck oncology and microvascular reconstruction ● Skin cancer ● Facial aesthetics.