bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrative computational approach identifies new targets in CD4+ T cell-mediated immune disorders
Authors: Puniya Bhanwar Lal , Amin Rada , Lichter Bailee , Moore Robert , Ciurej Alex , Townsend Sydney , Shah Ab Rauf , Barberis Matteo , Helikar Tomáš 
Published: January 2020

AbstractCD4+ T cells provide adaptive immunity against pathogens and abnormal cells, and they are also associated with various immune related diseases. CD4+ T cells’ metabolism is dysregulated in these pathologies and represents an opportunity for drug discovery and development. Genome-scale metabolic modeling offers an opportunity to accelerate drug discovery by providing high-quality information about possible target space in the context of a modeled disease. Here, we develop genome-scale models of naïve, Th1, Th2 and Th17 CD4+ T cell subtypes to map metabolic perturbations in rheumatoid arthritis, multiple sclerosis, and primary biliary cholangitis. We subjected these models toin silicosimulations for drug response analysis of existing FDA-approved drugs, and compounds. Integration of disease-specific differentially expressed genes with altered reactions in response to metabolic perturbations identified 68 drug targets for the three autoimmune diseases.In vitroexperimental validations together with literature-based evidence showed that modulation of fifty percent of identified drug targets has been observed to lead to suppression of CD4+ T cells, further increasing their potential impact as therapeutic interventions. The used approach can be generalized in the context of other diseases, and novel metabolic models can be further used to dissect CD4+ T cell metabolism.
Disputing space-based biases in unilateral complex regional pain syndrome
Authors: Halicka Monika , Vittersø Axel D , McCullough Hayley , Goebel Andreas , Heelas Leila , Proulx Michael J , Bultitude Janet H 
Published: January 2020

AbstractThere is some evidence that people with Complex Regional Pain Syndrome (CRPS) show reduced attention to the affected relative to unaffected limb and its surrounding space, resembling hemispatial neglect after brain injury. These neuropsychological symptoms could be related to central mechanisms of pathological pain and contribute to its clinical manifestation. However, the existing evidence of changes in spatial cognition is limited and often inconsistent. We examined visuospatial attention, the mental representation of space, and spatially-defined motor function in 54 people with unilateral upper-limb CRPS and 22 pain-free controls. Contrary to our hypotheses and previous evidence, individuals with CRPS did not show any systematic spatial biases in visuospatial attention to or representation of the side of space corresponding to their affected limb (relative to the unaffected side). We found very little evidence of directional slowing of movements towards the affected relative to unaffected side that would be consistent with motor neglect. People with CRPS were, however, slower than controls to initiate and execute movements with both their affected and unaffected hands, which suggests disrupted central motor networks. Finally, we found no evidence of any clinical relevance of changes in spatial cognition because there were no relationships between the magnitude of spatial biases and the severity of pain or other CRPS symptoms. The results did reveal potential relationships between CRPS pain and symptom severity, subjective body perception disturbance, and extent of motor impairment, which would support treatments focused on normalizing body representation and improving motor function. Our findings suggest that previously reported spatial biases in CRPS might have been overstated.
In vivoelectrophysiological validation of DREADD-based inhibition of pallidal neurons in the non-human primate
Authors: Deffains Marc , Haï Nguyen Tho , Orignac Hugues , Biendon Nathalie , Dovero Sandra , Bezard Erwan , Boraud Thomas 
Published: January 2020

AbstractDesigner Receptors Exclusively Activated by Designer Drugs (DREADDs) are widely used in rodents to manipulate neuronal activity and establish causal links between structure and function. Their utilization in non-human primates (NHPs) is however limited and their efficacy still debated. Here, we tested DREADD expression in the NHP external globus pallidus (GPe) and electrophysiologically validated DREADD-based inhibition of GPe neurons in the anesthetized monkey.To do so, we performed intracerebral injections of viral construct expressing hM4Di receptor under a neuron-specific promoter into the GPe. Then, we recorded the neuronal activity in the DREADD-transduced (test condition) and DREADD-free (control condition) GPe of two anesthetized animals following local intra-GPe microinjection of clozapine-N-oxide (CNO). In total, 19 and 8 well-isolated and stable units were recorded in the DREADD-transduced and DREADD-free GPe, respectively. Overall, we found that almost half (9/19) of the units modulated their activity following CNO injection in DREADD-transduced GPe. Surprisingly, neuronal activity of the GPe units exhibited diverse patterns in timing and polarity (increase/decrease) of firing rate modulations during and after CNO injection. Nevertheless, decreases were exclusive and stronger after CNO injection. In contrast, only one unit modulated its activity after CNO injection in DREADD-free GPe. Moreover, post-mortem histochemical analysis revealed that hM4Di DREADDs were expressed at high level in the GPe neurons located in the vicinity of the viral construct injection sites. Our results therefore showin vivoDREADD-based inhibition of pallidal neurons in the NHP model and reinforce the view that DREADD technology can be effective in NHPs.
Retirement village buying intention
Authors: Ng Siew Imm , Zhao Fang , Lim Xin-Jean , Kamal Basha Norazlyn , Sambasivan Murali 
Published: January 2020

PurposeThe well-being of the elderly is a growing issue of concern for countries around the world. One way to enhance the elderly well-being is to provide housing options suitable to their needs and lifestyle. Retirement village is an accommodation concept foreign to the Malaysian population. Therefore, the purpose of this paper is to bridge this literature gap by analyzing factors that may inhibit or motivate the buying intention of a retirement village unit among the elderly in Malaysia.Design/methodology/approachData were collected from 261 Malaysian elderly and analyzed using structural equation modeling PLS.FindingsThe results indicated that attitude, subjective norm, perceived behavioral control and social sustainability were significant predictors that explained elderly buying intention of retirement village.Originality/valueThe study also found a significant moderating role of religion in attitude–intention relationship. The paper concludes with the study’s implications, limitations and recommendations for future research.
Alternatives to culling male chicks – the consumer perspective
Authors: Reithmayer Corrina , Mußhoff Oliver , Danne Michael 
Published: January 2020

PurposeThe purpose of this paper is to investigate consumer preferences for boxes of eggs which are produced without the culling of male layer-type chicks in layer hen production and, furthermore, to investigate consumer preferences for labels from different certifying bodies.Design/methodology/approachAn online survey including a discrete choice experiment was conducted among 526 German consumers in 2018 and early 2019. Mixed logit models in preference and willingness to pay (WTP) space were estimated.FindingsThe preferred alternative is gender determination of incubated eggs, but also dual-use (DU) poultry with free-range rearing of cockerels was approved. Labels from public authorities and the Animal Protection Organisation were highly approved. In contrast, retailers were not considered suitable for the certification of production claims.Research limitations/implicationsA hypothetical setting was employed. A revealed preferences approach is suggested for future research.Practical implicationsEvidence for a wide approval of in ovo gender determination was found. Free-range rearing of cockerels was the most promising for the marketing of DU poultry products. Furthermore, public authorities and well-established third parties should engage in the field of animal welfare labelling.Originality/valueThis is the first study focussing on preferences and WTP for alternatives to chick culling, which will soon be available on the market, and for institutions certifying production claims. Findings help political decision makers, when looking for alternatives to the culling of day-old chicks, which are considered more acceptable by the public.
Reliability estimation in a multicomponent stress–strength based on unit-Gompertz distribution
Authors: Jha Mayank Kumar , Dey Sanku , Tripathi Yogesh Mani 
Published: January 2020

PurposeThe purpose of this paper is to estimate the multicomponent reliability by assuming the unit-Gompertz (UG) distribution. Both stress and strength are assumed to have an UG distribution with common scale parameter.Design/methodology/approachThe reliability of a multicomponent stress–strength system is obtained by the maximum likelihood (MLE) and Bayesian method of estimation. Bayes estimates of system reliability are obtained by using Lindley’s approximation and Metropolis–Hastings (M–H) algorithm methods when all the parameters are unknown. The highest posterior density credible interval is obtained by using M–H algorithm method. Besides, uniformly minimum variance unbiased estimator and exact Bayes estimates of system reliability have been obtained when the common scale parameter is known and the results are compared for both small and large samples.FindingsBased on the simulation results, the authors observe that Bayes method provides better estimation results as compared to MLE. Proposed asymptotic and HPD intervals show satisfactory coverage probabilities. However, average length of HPD intervals tends to remain shorter than the corresponding asymptotic interval. Overall the authors have observed that better estimates of the reliability may be achieved when the common scale parameter is known.Originality/valueMost of the lifetime distributions used in reliability analysis, such as exponential, Lindley, gamma, lognormal, Weibull and Chen, only exhibit constant, monotonically increasing, decreasing and bathtub-shaped hazard rates. However, in many applications in reliability and survival analysis, the most realistic hazard rates are upside-down bathtub and bathtub-shaped, which are found in the unit-Gompertz distribution. Furthermore, when reliability is measured as percentage or ratio, it is important to have models defined on the unit interval in order to have plausible results. Therefore, the authors have studied the multicomponent stress–strength reliability under the unit-Gompertz distribution by comparing the MLEs, Bayes estimators and UMVUEs.
Soft power and nation rebranding
Authors: Li Eric Ping Hung , Min Hyun Jeong , Lee Somin 
Published: January 2020

PurposeThe purpose of this paper is to explore the interconnection between the corporatisation of K-beauty and Korea’s nation branding exercise and its links with soft power. Through the investigation of the transformation of Korea’s beauty industry, the authors seek to illustrate the inter-relationship of the market systems and national identification practices.Design/methodology/approachThis study employed the qualitative case study approach to examine the latest development of Korea’s medical tourism. Through analysing a variety of secondary data that associated to the latest development of cosmetic tourism, this paper presents the impact of the transformation and reconfiguration of Korea’s beauty industry on the country’s nation branding strategy and the development of Korea’s soft power in the global marketplace.FindingsThe findings highlight how Korea’s new cosmetic tourism industry contributed to the renewal of Korea’s nation brand in the global market. The findings also illustrate the interconnection of the emerging Korean popular cultural products (K-pop and K-beauty) in the regional and global marketplace.Research limitations/implicationsThe findings demonstrate the role of market in re-defining a nation’s brand and identity. The findings also illustrate how market-driven strategy influences the development of a nation’s soft power in the regional and/or global marketplace.Practical implicationsThe study shows that practitioners can be active agents in nation branding. Through highlighting strategies to develop soft power within and beyond the country boundary, this study shows how market agents, governments and other stakeholders can co-create a market system that transform and reconfigure the nation brand in the global marketplace.Social implicationsIn additional to explore the transformation of the beauty industry in Korea, this paper also presents the history and transformation of the beauty standards in Korea and other Asian cultures. Such dialogue invites marketing and consumer researchers to further explore the role of history and culture in guiding the production and consumption of new (consumption) standards.Originality/valueThis is the first paper that connects the theory of soft power in nation branding and country-of-origin literature. The case analysis of the socio-historical development of K-beauty also demonstrates how non-Western cultural goods enter the international marketplace. In summary, this paper provides new conceptual framework that illustrates a new collaborative mechanism that engages government and practitioners to co-create new cultural norms and standards to the local and international markets.
Multi-level framework for anomaly detection in social networking
Authors: Khamparia Aditya , Pande Sagar , Gupta Deepak , Khanna Ashish , Sangaiah Arun Kumar 
Published: January 2020

Purpose
The purpose of this paper is to propose a structured multilevel system that will distinguish the anomalies present in different online social networks (OSN).

Design/methodology/approach
Author first reviewed the related work, and then, the research model designed was explained. Furthermore, the details regarding Levels 1 and 2 were narrated.

Findings
By using the proposed technique, FScore obtained for Twitter and Facebook data set was 96.22 and 94.63, respectively.

Research limitations/implications
Four data sets were used for the experiment and the acquired outcomes demonstrate enhancement over the current existing frameworks.

Originality/value
This paper designed a multilevel framework that can be used to detect the anomalies present in the OSN.
The research landscape of big data: a bibliometric analysis
Authors: Liu Xiaohong , Sun Ruiqing , Wang Shiyun , Wu Yenchun Jim 
Published: January 2020

Purpose
In recent years, the rapid growth of big data has presented immense potential for business applications as well as raised great interest from academia. In response to this emerging phenomenon, the purpose of this paper is to provide a comprehensive literature review of big data.

Design/methodology/approach
A bibliometric method was used to analyze the articles obtained from the Scopus database published between 2013 and 2018. A sample size of 4,070 articles was evaluated using SciVal metrics.

Findings
The analysis revealed an array of interesting findings as follows: the number of publications related to big data increased steadily over the past six years, though the rate of increase has slowed since 2014; the scope of big data research is quite broad in regards to both research domains and countries; despite a large volume of publications, the overall performance of big data research is not well presented as measured by the field-weighted citation impact metric; collaboration between different institutions, particularly in the form of international collaboration and academic–corporate collaboration, has played an important role in improving the performance of big data research.

Originality/value
To the best of the authors’ knowledge, this is the first study to provide a holistic view of the big data research. The insights obtained from the analysis are instrumental for both academics and practitioners.
Investigating users’ willingness of acceptance for background music service in intelligent library
Authors: Liu Yang 
Published: January 2020

PurposeThe purpose of this paper is to study the users’ willingness for acceptance of background music service in university libraries based on intelligent campus and to improve the intelligence level of university libraries and provide a reference for the atmosphere.Design/methodology/approachThe research method of combining theory with practice is applied, and field distribution method and network survey method are used. An algorithm model is established to investigate relevant users, and statistical analysis of the data obtained is made.FindingsThe results show that in the questionnaire survey, girls are more inclined to study in the environment of library than boys; for grade, sophomores and juniors are more inclined to go to library than other grades; through model analysis, the target users are more inclined to choose light music as background music, accounting for 65 percent. Heavy metals and other users have fewer choices, accounting for only 8 percent.Research limitations/implicationsThis questionnaire is mainly filled out in paper form on site, so it only selects some nearby students as the survey objects. However, the condition of university libraries across the country must be different due to regional differences, disciplinary differences and funding differences, so the representative sample may be insufficient. Therefore, in the follow-up research, the scope of the survey should be expanded, especially the geographical scope. It should collect as much data as possible for students of different types and genders, so as to expand the applicable scope and explanatory power of the model.Practical implicationsStarting from the library scene, this research studies the acceptance intention of users of background music service in the library, which provides reference for the improvement of the intellectualization of university libraries and their atmosphere. Although different university libraries have different operation modes and service characteristics, the conclusions of this study have certain practical significance for the library industry because the library industry has many commonalities.Originality/valueAt present, the research on the background music service of University Library based on the smart campus is relatively rare and limited to the theoretical stage. Few people have deeply explored the background music service of the library, and no scholars have quantitatively studied it. In this study, based on the questionnaire and from the perspective of users, the acceptance intention of background music service users is investigated, which provides a reference for the improvement of the intellectualization of university libraries and its atmosphere. It is a research topic of great practical significance.
Theoretical foundations and applications of cyber-physical systems: a literature review
Authors: Zhang Caiming , Xu Xiaojun , Chen Hong 
Published: January 2020

Purpose
The purpose of this paper is to review the current research on theoretical foundations and applications for CPS from 2017 to 2019 including the applications in library.

Design/methodology/approach
This paper is designed in six parts as Introduction, Literature review, Theoretical foundations of CPS, Applications of CPS, CPS’s application in library and Conclusion. The authors review 70 papers and classify them as the above six parts. The authors collected 70 papers from 2017 to 2019 in the academic databases.

Findings
This paper reviews 70 papers regarding theoretical foundations and applications for CPS from 2017 to 2019 in the academic databases aiming to provide scholars and practitioners with a comprehensive overview. The contents of the papers in each research category are summarized from theoretical foundations and applications including the CPS applications in library.

Originality/value
A main contribution of this review paper is that it summarizes the current state-of-the-art theoretical foundations and applications for CPS and in libraries systematically.
Equivalent gambling warning labels are perceived differently
Authors: Newall Philip W. S. , Walasek Lukasz , Ludvig Elliot A. 
Published: January 2020

AbstractBackground and AimsThe same information may be perceived differently, depending on how it is described. The risk information given on many gambling warning labels tends to accentuate what a gambler might expect to win, e.g. ‘This game has an average percentage payout of 90%’ (return‐to‐player), rather than what a gambler might expect to lose, e.g. ‘This game keeps 10% of all money bet on average’ (house‐edge). We compared gamblers’ perceived chances of winning and levels of warning label understanding under factually equivalent return‐to‐player and house‐edge formats.DesignOnline surveys: experiment 1 was designed to test how gamblers’ perceived chances of winning would vary under equivalent warning labels, and experiment 2 explored how often equivalent warning labels were correctly understood by gamblers.SettingUnited Kingdom.ParticipantsUK nationals, aged 18 years and over and with experience of virtual on‐line gambling games, such as on‐line roulette, were recruited from an on‐line crowd‐sourcing panel (experiment 1, n = 399; experiment 2, n = 407).MeasurementsThe main dependent variables were a gambler's perceived chances of winning on a seven‐point Likert scale (experiment 1) and a multiple‐choice measure of warning label understanding (experiment 2).FindingsThe house‐edge label led to lower perceived chances of winning in experiment 1, F(1, 388) = 19.03, P < 0.001. In experiment 2, the house‐edge warning label was understood by more gamblers [66.5, 95% confidence interval (CI) = 60.0%, 73.0%] than the return‐to‐player warning label (45.6%, 95% CI = 38.8%, 52.4%, z = 4.22, P < 0.001).ConclusionsHouse‐edge warning labels on electronic gambling machines and on‐line casino games, which explain what a gambler might expect to lose, could help gamblers to pay greater attention to product risk and would be better understood by gamblers than equivalent return‐to‐player labels.