bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and Characterization of Polymeric Peptides for Antibody Tagging of Bacterial Targets
Authors: Climacosa Fresthel Monica M. , King Ruby Anne N. , Santos Bobbie Marie M. , Caoili Salvador Eugenio C. 
Published: April 2020

Background:
Microbe-Binding Peptides (MBPs) are currently being investigated to address
the problem of antimicrobial resistance. Strategies enhancing their antimicrobial activity have
been developed, including peptide dimerization. Here, we present an alternative approach based on
peptide polymerization, yielding hapten-labelled polymeric MBPs that mediate tagging of bacteria
with anti-hapten antibodies, for enhanced immune recognition by host phagocytes.

Methods:
C-terminally amidated analogs of the bacterial-binding peptide IIGGR were synthesized,
with or without addition of cysteine residues at both N- and C-termini. Peptides were subjected to
oxidizing conditions in a dimethyl-sulfoxide/water solvent system, and polymerization was demonstrated
using SDS-PAGE. Peptides were then N-terminally labelled with a trinitrophenyl (TNP)
group using trinitrobenzene sulfonate (TNBS). Binding to representative bacteria was demonstrated
by ELISA using anti-TNP antibodies and was quantified as half-maximal effective concentration
(EC50). Minimum Inhibitory Concentration (MIC) and concentration yielding 50% hemolysis
(H50) were estimated. Neutrophil phagocytic index was determined for TNP-labelled polymeric bacterial-
binding peptide (Pbac) with anti-TNP antibodies and/or serum complement.

Results:
Polydisperse Pbac was synthesized. EC50 was lower for Pbac than for the corresponding
monomeric form (Mbac), for both Staphylococcus aureus ATCC 29213 and Escherichia coli
ATCC 25922. MIC and H50 were >250μg/mL for both Pbac and Mbac. A complement-independent
increase in neutrophil phagocytic index was observed for E. coli treated with TNP-labelled Pbac in
conjunction with anti-TNP antibodies.

Conclusion:
Our data suggest that hapten-labelled polymeric bacterial-binding peptides may easily
be produced from even crude synthetic oligopeptide precursors, and that such bacterial-binding peptides
in conjunction with cognate anti-hapten antibodies can enhance immune recognition of bacteria
by host phagocytes.
GC-MS Based Metabolic Profiling of Parkinson’s Disease with Glutathione S-transferase M1 and T1 Polymorphism in Tunisian Patients
Authors: Rebai Amal , Reçber Tuba , Nemutlu Emirhan , Chbili Chahra , Kurbanoglu Sevinç , Kir Sedef , Amor Sana B. , Özkan Sibel A. , Saguem Saad 
Published: April 2020

Aim and Objective:
Parkinson’s disease (PD) is the second most common
neurodegenerative disease. It is a multifactorial disorder (caused by aging, environmental, and
genetic factors). Metabolomics can help explore the biomarker profiles for aging. Recent studies
showed an association between the glutathione S-transferases (GSTs) polymorphisms and PD risk.
The purpose of this study was to evaluate the association of this genetic polymorphism and the
metabolomic profile in PD Tunisian patients, in order to identify effective biomarkers in the
genetic differentiation.

Materials and Methods:
In this study, the metabolomic profile changes related to GSTs
polymorphism were searched in 54 Tunisian PD patients treated with L-dopa, using a gas
chromatography-mass spectrometry (GC-MS) technique.

Results:
The study results showed that mannose, methyl stearate, and three other unknown
metabolites, increased in patients with GSTM1 positive genotype, while glycolic acid, porphine,
monomethyl phosphate, fumaric acid, and three other unknown metabolites decreased in patients
with GSTM1 positive genotype. Subsequently, the levels of glycolic acid, erythronic acid, lactic
acid, citric acid, fructose, stearic acid, 2-amino-2-methyl-1,3-propanediol and three other unknown
metabolites increased in patients with GSTM1 positive genotype, while the levels of proline, valine
and two unknown metabolites decreased with GSTT1 positive genotype.

Conclusion:
All these altered metabolites are related to energy metabolism and it can be concluded
that GSTs polymorphism based the shifting in energy metabolism and led to oxidative stress.
Modulation of Small Artery Function by Insulin in Young Women: Role of Adiposity
Authors: Banerjee Moulinath , Shaw Linda , Charlton-Menys Valentyn , Pemberton Phillip , Malik Rayaz Ahmed , Cruickshank John Kennedy , Austin Clare Elizabeth 
Published: April 2020

Objectives:
Vascular dysfunction is common in obesity. Insulin can directly modulate arterial
function, but its role is unclear in obesity. We examined the influence of adiposity on direct effects
of insulin on human artery responses.

Methods:
22 healthy women were stratified by median BMI into lower (LA) (n=11) and higher adiposity
(HA) (n=11). Small arteries from gluteal biopsies were tested for contractile responses to
Noradrenaline (NA), the endothelium-dependent dilator Carbachol and the endothelium-independent
dilator sodium nitroprusside were examined before and after incubation with 100 mU/ml human insulin.

Results:
Contractile responses were similar in the two groups. Insulin reduced NA-induced contraction
in HA [3.5 (2.4-4.6) vs. 2.4 (1.4-3.4) mN/mm: p=0.004] but not those from LA [4.1 (2.8-5.3) vs. 3.7
(2.5-5.0) mN/mm: p=0.33]. Endothelium-dependent dilation (EDD) was significantly reduced in arteries
from women in the HA (34.7 (18.8-50.6%)) compared to those from women in the LA (62.3 (46.2-
78.4); p=0.013). Insulin improved EDD (change in maximal dilation before/after insulin (%)) in arteries
from the HA (37.7 (18.0 to 57.3) but not the LA (6.3 (-6.5 to 19.1), p=0.007.

Conclusion:
Reduced EDD evident in arteries from HA subjects improve by incubating in insulin.
Hyperinsulinaemia may be necessary in maintaining endothelial function in obesity.
DETERMINATION OF SUSTAINABLE BUSINESS FACTORS OF ISLAMIC BANKS IN INDONESIA
Authors: Siswanti Indra 
Published: April 2020

The objective of the study is to test and analyze the influence of corporate intellectual capital and company size on sustainable business through financial performance as a mediating variable. The data used was secondary data of financial and annual reports for 2010-2018 period. The population of this study was 9 (nine) Islamic Banks, and the samples used were saturated sampling, thus the sample used was all the 9 (nine) Islamic Banks. The data processing method used is Partial Least Square (PLS). The results of the study found that intellectual capital has a significant effect on financial performance, company size Â has a significant effect on financial performance, where as intellectual capital has no effect on sustainable business. The study Â found that financial performance has a significant effect on sustainable business. Financial performance has a full mediating influence of intellectual capital on sustainable business, and financial performance has a partial mediating influence of company size on sustainable business.Â Keywords:Â Intellectual Capital, Company size, Financial Performance, and Sustainable Business
Phytochemicals Analysis and Cytotoxicity Activity of Ethanol Extract of Litseacubeba Lour.Heartwood
Authors: M Fujiko , A Dalimunthe , M Masfria 
Published: April 2020

Objective: The purpose of this study was to determine the chemical compounds whichcontained in the ethanol extract and cytotoxic activity ethanol extract of Litseacubeba heartwood induced in T47D cells.
Methods: The ethanol extract was extracted by maceration using ethanol 96% solvent. Cytotoxic activity was determined with MTT method and the IC50analyzed using SPSS 23.
Results: Phytochemicals screening were showed that the ethanol extract of Litseacubeba heartwood contained steroids/triterpenoids, glycosides, alkaloids, flavonoids, saponins and tannins. The IC50of ethanol extract of Litseacubeba heartwood were 349,57 ±0,35μg/ml in T47D cells.
Conclusions: Ethanol extract of Litseacubeba heartwood has activity as an anticancer to T47D cells breast cancer agents.
Comparison of In-Vitro Dissolution of Griseofulvin Tablet made from Nano Particles and Solid Dispersion
Authors: Karima Nurul , Sumaiyah Sumaiyah , Nasution Azizah 
Published: April 2020

Objectives: To find out the comparison of dissolution results of griseofulvin tablets made from nanoparticles, solid dispersions, and conventional materials.
Interventions: Different types of active ingredients in the form of nanoparticles and solid dispersions can affect the dissolution results of tablets.
Main outcomes measure: The results obtained in this study are the cumulative dissolution percentage and the order kinetics of the release of active ingredients.
Conclusion: There was no significant cumulative percent drug release difference (p> 0.05) between nano particles, solid dispersions, and conventional materials. Tablets containing active nanoparticles, solid dispersions, and conventional materials show a linear relationship with a correlation coefficient (R2) close to 1, shown in zero-order kinetics models.
Evaluation of Drug Management Achievement in Pharmacy Installation of Langsa General Hospital
Authors: M Mauliana , W Wiryanto , Harahap Urip 
Published: April 2020

Objective: to evaluate the achievements of drug management in Pharmacy Installation of Langsa General Hospital
Design: The study used descriptive designs for 2018 data which were retrospective and prospective. Data was collected in the form of quantitative and qualitative data from document observations and interviews with relevant Pharmacy Installation officers.
Interventions: the intervened variable were drug selection, planning and procurement, and distribution.
Main outcome measures: the main measurement in this study were suitability of drug items available with the National Formulary, frequency of procurement of each drug item per year, accuracy of data on the number of drugs on the stock card, percentage and value of expired and / or damaged drugs, percentage of dead stock and level of drug availability.
Results: drug management system that conformed to the following standards were the suitability of the available drug items with the National Formulary (88.37%); the accuracy of data on the number of drugs on the stock card (100%) and drug availability (13 months 14 days). Drug mangement which were not accordance with standard: the frequency of procurement of each drug item per year; percentage of expired and / damaged drug values (2.64%) and percentage of dead stock (3.24%).
Conclusion: it could be concluded that the management of drugs in Langsa General Hospital Pharmacy Installation had not been fully effective and efficient in accordance with established standards.
Health-related quality of life and health utility among patients with diabetes: in Zabol, Southeast Iran
Authors: Hedayati Seyed Pouria , Haghparast-Bidgoli Hassan , A. Kiadaliri Aliasghar , Mohabati Fatemeh 
Published: April 2020

Objective: The current study aimed to assess the factors associated with HRQoL and HU among Patients with diabetes in Zabol, Southeast Iran.
Methods: Among patients referred to Zabol city diabetes clinic, a total of 213 consecutive patients 18 years and older consent to participate in the study in 2015. The Persian version of EuroQol-5D-3L (EQ-5D-3L) using the UK preference weights was applied to derive HU. Logistic regression and ordinary least squares were used for data analysis. The STATA version 13 (StataCorp LP, College Station, TX, USA) was used for statistical analysis.
Results: The highest and lowest proportions of "some or extreme problems" were seen in pain/discomfort (86.6%) and self-care (27.8%) dimensions of the EQ-5D-3L, respectively. About 33% of women and 14% of men rated their health worse than death (p=0.002). The mean EQ-5D-3L index score and visual analogue scale were 0.37 (95% CI: 0.31-0.42) and 51.6 (95% CI: 48.7-54.5), respectively. Older age at diagnosis, longer duration of diabetes, lower education, and history of macrovascular complications were associated with lower HRQoL and HU.
Conclusion: This study highlights the importance of education and diabetes-related complications in HRQoL/HU of diabetes people. The findings suggest that urgent interventions are required to improve HRQoL/HU of diabetes patients in Zabol. Moreover, our results provide inputs for future economic evaluation studies among diabetes patients with similar socioeconomic status in Iran.
Optimasi Dashboard Information System Stikom Bali Dengan Algoritma Levenshtein Distance
Authors: Sumiari Ni Kadek , Ari Jayanti Ni Ketut Dewi 
Published: April 2020

Kebutuhan data dan informasi bagi perguruan tinggi sangatlah penting salah satunya adalah bagi para eksekutif. Pada perguruan tinggi data dan informasi diperlukan untuk membuat dokument keperluan akreditasi atau sebagai pelaporan tahunan pada Rapat Tinjauan Manajemen (RTM). Untuk mempermudah eksekutif dalam memperoleh informasi data yang akurat maka keberadaan Dashboard Information System dalam perguruan tinggi cukup penting. STMIK STIKOM Bali merupakan salah satu perguruan tinggi yang sudah menerapkan Dashboard Infromation System bagi para eksekutif untuk memperoleh data dari semua system informasi yang sudah terintegrasi. Melalui Dashboard Information System Eksekutif STMIK STIKOM Bali dapat melihat informasi data yang realtime. Dashboard Infromation System STMIK STIKOM Bali dirancang menggunakan metode analisa FAST (Framework for the Application of Sistem Thinking) serta dibangun berbasis web dengan bahasa pemrograman PHP dan framework bootstrap. Pada Dashboard Infromation System pencarian data merupakan salah satu fungsi penting. Agar pencarian data lebih optimal maka perlu diterapkan sebuah algoritma untuk pencarian data. Pada Dashboard Infromation System STMIK STIKOM Bali diimplementasikan algoritma levenshtein distance untuk optimasi dalam pencarian data. Hasil setelah diimplemnatsikan algoritma levensthein distance pada Dashboard Infromation System adalah terdapat rekomendasi terdekat kata apabila user salah dalam melakukan input data sehingga pencarian lebih optimal. Kata Kunci — Dashboard Information System, Optimasi, Levenshtein Distance Data requirements and information on universities are very large, especially for management executives. In higher education the data and information needed to make documents are in accordance with the annual management report. To facilitate communication in using the right information data and Information System Dashboard Information in higher education is quite important. STMIK STIKOM Bali is one of the universities that has implemented an Information System Dashboard for executives to obtain data from all integrated information systems. Through the Executive Dashboard Information System STMIK STIKOM Bali can see real-time data information. Dashboard Information System STMIK STIKOM Bali will use the FAST analysis method (Thinking System Application Framework) and build web-based with PHP and bootstrap framework. On the Information System Dashboard look for data for one important function. In order to search data more optimally it is necessary to apply an algorithm to find data. In the STMIK STIKOM Bali Dashboard Information System levenshtein distance algorithm is implemented for optimization in data search. The results after implementing the Levensthein distance algorithm on the Information System Dashboard are one of the most complete of user errors in performing optimal data input. Keywords — Dashboard Information System, Optimization, Levenshtein Distance
THE EFFECTS OF TECHNOSTRESS CREATORS AND ORGANIZATIONAL COMMITMENT AMONG SCHOOL TEACHERS
Authors: Hassan Narehan , Yaakob Siti Aisyah , Mat Halif Mazuin , Abdul Aziz Rozilah , Abdul Majid Afiza , Sumardi Nur Athirah 
Published: April 2020

In the fast-paced world, information is retrieved and stored efficiently using IT technologies. Due to the constant change and advancement in technology, technostress has become a critical issue in many organizations especially for those who are IT illiterate. This scenario is especially true for school teachers in Malaysia where students’ information is stored and retrieved using a database system and posted online for quick accessibility of files and student management. However, for those who are not IT-skilled, this type of work demand can influence both the employee’s motivation and work commitment. School teachers in Malaysia are found to be overworked and most had to take home their work, especially in updating students’ information. The changing work demands and the need to perform both teaching and administrative duties have resulted in teachers facing a stressful working environment. This is especially true for senior teachers, whose IT skill is often lagging compared to their younger counterparts; hence the term technostress is coined -- not only to teachers but to those who are lacking in IT-related skills. Teachers’ commitment is of utmost importance to produce better workforce for the future. Hence, this study was conducted to examine both the relationship and the effects of techno-stress creators and organizational commitment among school teachers. This study was carried out at six schools in Selangor involving 173 school teachers. The findings revealed that two dimensions of techno-stress creators which were techno-uncertainty and techno-insecurity had positive and significant influence on organizational commitment while all other three elements of techno-stress creators which were techno-overload, techno-invasion and techno complexity did not predict teachers’ organizational commitment. The findings also revealed that certain amount of techno-stress can enhance the level of teachers’ commitment.
Promoting Empathy Using Design Thinking in Project-Based Learning and as a Classroom Culture
Authors: Md Hashim Adila , Syed Aris Sharifah Ruzaina , Chan Yuen Fook 
Published: April 2020

This paper explores the benefits of empathy skill for school students. The encouragement of empathy skill in school was discussed in two situations: 1. Using design thinking approach for project-based learning and 2. Promoting as a classroom culture. Empathy is an act of understanding, being conscious and experiencing the feeling and thoughts of other people. It is the key to inspire social innovation and diminishing prejudice against others. Empathy skill has affected our feeling of wellbeing and human centeredness to provide an understanding of people’s needs. By integrating design thinking process in school, students will equip themselves with empathy-related skills such as communication, observation, decision-making and positive relationship with others as part of their active learning process. Adapting design thinking in project-based learning requires students to be aware and concern in exploring human-driven design which leads to user satisfaction for any problem’s solution. Empathy also has the advantage of forming a positive classroom culture and sustaining a good teacher-student relationship. This paper discussed how the design thinking process can promote empathy skill during project-based learning for humanizing decision-making and the opportunity for empathy integration in the classroom to engage in positive collaboration and teamwork.

KEYWORDS: Classroom Culture, Design Thinking, Empathy, Project-Based Learning
STEM Integration: Factors Affecting Effective Instructional Practices in Teaching Mathematics
Authors: Mohd Rasid Nor Syazwani , Md Nasir Nurul Akmal , A/l Aperar Singh Parmjit Singh , Cheong Tau Han 
Published: April 2020

Malaysian Ministry of Education (MOE) has created initiatives in the Malaysian Education Blueprint (2013- 2025 that aim to increase teachers’ and students’ competencies in Science, Technology, Engineering and Mathematics (STEM) subjects and create learning experiences that will prepare students for the considerable array of STEM career fields. There are so many effective instructional practices suggested in integrating STEM education for teaching Mathematics. However, there are some factors that need to be concerned in producing effective instructional practices in teaching Mathematics. This study investigated the factors affecting instructional practices of mathematics since the implementation STEM education. Using a descriptive design method, a questionnaire was administered to 100 students and 50 mathematics teachers in Klang Valley. The overall mean score of all four factors (Lesson plan and implementation, Mathematical discuss and sensemaking, task implementation, and classroom culture) measured in this study is moderately high based on students’ and teachers’ perspectives. Teachers rated all factors higher than students’ rate. Both teachers and students agreed that classroom culture is the important factor. There are no significant differences in the mean score of factors among gender of students and teachers. There is a significant difference in the mean score of factors among the achieving abilities among the students.
Keywords: STEM Education, Mathematics, Lesson plan, Task, Classroom culture, Mathematical discuss
M-Track: Progress Tracking System for MOOC Development
Authors: Md Noor Harrinni , Aziz Anealka 
Published: April 2020

In 2014, the Ministry of Education initiated Massive Open Online Course (MOOC) pilot project at public universities in Malaysia. Universiti Teknologi MARA (UiTM) was selected among three public universities to develop the university’s own MOOC. This pilot project is one of the initiatives by the Malaysian government to support the ninth shift of Malaysia Education Blueprint 2015 – 2025 (Higher Education): Globalized Online Learning, which is introduced to achieve the desired outcomes set by the National e-Learning Policy (Dasar e-Pembelajaran Negara or DePAN). All MOOCs are now available on the Open Learning platform and offered throughout the year. It is a huge task indeed to manage and monitor simultaneous MOOC development in all UiTM faculties and state campuses. Thus, a tracking system to monitor the progress of MOOC development by lecturers called the M-Track System was designed. This paper explains how the system was developed and implemented. The system facilitates e-learning administrators to monitor the quality of MOOC at all 26 faculties and 12 UiTM campuses throughout Malaysia before there were offered to the public.The system can generate several types of report and this ensures the duration of MOOC development is adhered to. The target users of the system are the MOOC developers, MOOC Coordinators, MOOC Managers at the institution and anyone who wishes to develop MOOC.
Keywords: MOOC tracking, MOOC development, MOOC monitoring, MOOC reporting
PSYCHOPATHY
Authors: COOKE David J. 
Published: April 2020

Psychopathy is an important forensic construct. Psychopathic personality disorder has long been recognized as an important forensic construct. It has relevance for violence, treatability and manageability. It is a construct that can have a disproportionate influence on decision making and ethical forensic practice requires practitioners to take cognizance of the limitations of our current assessments.
STUDYING THE PROCEDURE COMPONENT OF LEARNING MOTIVES OF STUDENTS WITH DIFFERENT GPA
Authors: KELOYAN Mari 
Published: April 2020

The article focuses on the study of the procedural component of students' learning motives from the faculties of humanities of ASPU. As an academic task has been taken reading comprehension, and reading comprehension actions have been considered as procedural components of learning motives.
The focus group method was chosen as an effective method for studying the above-mentioned issue. The results of the focus group study, that's the variety of reading comprehension actions of students with different GPA (Grade Point Average) were revealed and grouped. The actions or strategies of medium and especially low GPA students are poor for ensuring deep comprehension of academic texts, which in its turn decreases learning motivation, while students with high-GPA mainly perform mental actions of different complexity levels for ensuring text comprehension which in turn increases intrinsic learning motivation.