bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short-term outcomes of mirogabalin in patients with peripheral neuropathic pain: a retrospective study
Authors: Tetsunaga Tomoko , Tetsunaga Tomonori , Nishida Keiichiro , Misawa Haruo , Takigawa Tomoyuki , Yamane Kentaro , Tsuji Hironori , Takei Yoshitaka , Ozaki Toshifumi 
Published: May 2020

Abstract
Background
Mirogabalin, which is approved for the treatment of peripheral neuropathic pain in Japan, is a ligand for the α2δ subunit of voltage-gated calcium channels. Both pregabalin and mirogabalin act as nonselective ligands at the α2δ-1 and α2δ-2 subunits. Mirogabalin has a unique binding profile and long duration of action. Pregabalin has been reported to produce intolerable adverse effects in some patients. This study investigated outcomes associated with mirogabalin administration in patients with peripheral neuropathic pain who ceased treatment with pregabalin.

Methods
We retrospectively assessed peripheral neuropathic pain using the neuropathic pain screening questionnaire (NeP score) in 187 patients (58 men, 129 women) who were treated with mirogabalin. All patients had switched from pregabalin to mirogabalin due to lack of efficacy or adverse events. Differences in the treatment course (i.e., numeric rating scale (NRS) scores) were compared using one-way analysis of variance with Bonferroni post hoc tests.

Results
The mean age of the patients was 72.3 years (range, 30–94 years), and the mean duration of disease was 37 months (range, 3–252 months). After treatment with mirogabalin for 1 week, NRS scores significantly decreased compared with baseline and continued to decrease over time. After 8 weeks, NRS scores improved by ≥ 30% from baseline in 113 patients (69.3%). Twenty-four patients (12.8%) stopped mirogabalin treatment due to adverse events. Somnolence (26.7%), dizziness (12.3%), edema (5.9%), and weight gain (0.5%) were noted as adverse events of mirogabalin.

Conclusions
The results of this investigation indicate that mirogabalin is safe and effective for reducing peripheral neuropathic pain.
Food security in rural Burkina Faso: the importance of consumption of own-farm sourced food versus purchased food
Authors: Fraval Simon , Yameogo Viviane , Ayantunde Augustine , Hammond James , de Boer Imke J. M. , Oosting Simon J. , van Wijk Mark T. 
Published: May 2020

Abstract
Background
The number of undernourished people and the risk of micro-nutrient deficiency remain high in sub-Saharan Africa (SSA). Decades of policy designed to reverse the trends of food insecurity have illustrated that the causal pathways of intervention to end-point outcomes, such as nutrition, are not necessarily straightforward. Utilising proxies for dimensions of food security, this study investigates the relative importance of different pathways to food security in two subtly contrasting communities in the Sahelian and Sudanian Savanna zones of Burkina Faso.

Results
In Yatenga province, approximately 31% of households were classified as ‘severely food insecure’ in the ‘lean’ period. In contrast, over 84% of households sampled in Seno province were classified as being ‘severely food insecure’ in the ‘lean’ period. There were statistically significant associations between food security indicators and off-farm income, farm income and production diversity. The source of income had significantly different associations with diet diversity in the two provinces. In Yatenga province, higher gross farm income in the absence of off-farm income was predicted to result in more diverse diets; in Seno province, however, gross farm income was only predicted to result in more diverse diets when households are also earning off-farm income.

Conclusions
Our analysis shows that households were most differentiated by income generating pathways to food security in the ‘lean’ period. This finding should not detract from the essential role played by home-produced foods in improving food security. Rather, market-orientated agriculture and production for home consumption, as shown by households in this study, can be combined as part of a more resilient livelihood strategy. Policy needs to be targeted towards agro-ecological conditions, as well as socioeconomic factors in order to facilitate improved on-farm income, farm resilience and off-farm employment opportunities.
Efficacy of indigenous strain of entomopathogenic nematode against diapausing larvae of Codling moth, Cydia pomonella L. (Lepidoptera: Tortricidae), in apple-growing hilly areas of Ladakh Region
Authors: Ahmad Mohammad Jamal , Mohiudin Sajad , Askary Tarique Hassan , Patil Jagadeesh 
Published: May 2020

AbstractIndigenous entomopathogenic nematode, Heterorhabditis pakistanensis, NBAIR H-05 strain was evaluated against diapausing larvae of the Codling moth, Cydia pomonella L. (Lepidoptera: Tortricidae) at 3 different dosages, i.e., at 15, 20, and 25 gm/ l of water in apple orchards at the district Kargil of Ladakh Region, India, during 2017 and 2018.Two year’s pooled average density of diapausing ranged 34.6 to 56.8 larvae/trunk band before treatment, which declined ranging 43.85 to 86.27 % with respect to different treatments of entomopathogenic nematode at concentrations between 7.5 × 105 IJs to 1.25 × 106 IJs/tree. Percent reduction in larvae over control varied from 41.78 to 85.77% for 7.5 × 105 IJs and 1.25 × 106 IJs respectively. Two-year pooled data indicated larval mortality between 39.85 and 73.38% and 4.0 to 12.89% with respect to different treatments at 48 and 72 h respectively, with statistically significant difference (P = ˂ 0.001). Increase in dosage of nematode formulation from 15 gm to 25 gm resulted in increased larval mortality (r = 0.92**). Post wetting of trunk band after 24 h in each treatment resulted in significantly higher larval mortality than non-post wetting. There was non-significant difference (t = 0.83) between larval mortality with respect to treatments during 2017 and 2018.
Palynomorph assemblage biozonation of Paleogene strata in Bende–Umuahia Area, Niger Delta Basin, southeastern Nigeria
Authors: Ikegwuonu Okechukwu Nicodemus , Umeji Obianuju Patricia , Chiaghanam Osita Igwebuike , Nwozor Kingsley K. , Ndukwe Otobong Sunday , Chiadikobi Kingsley Chukwuebuka 
Published: May 2020

AbstractCenozoic sediments form extensive outcrops in the Niger Delta Basin. Detailed palynostratigraphic study was undertaken across Paleogene sequences exposed in Bende–Umuahia Area in up-dip sectors of the Niger Delta Basin, southeastern Nigeria, to establish different palynomorphs assemblage zones, with their corresponding ages. Palynological analysis was carried out on 27 selected outcrop samples, using the conventional maceration technique for recovering acid-insoluble organic-walled microfossils from sediments. Three Cenozoic lithostratigraphic units, including Imo Formation, Ameki Formation, and Ogwashi Formation, are exposed in the study area. Lithologies are sandstone, carbonaceous shale, mudstone, limestone, and the lignite. A total of 65 species of sporomorphs and 51 dinoflagellate cysts were identified. The recovered spores and pollen grains were used to establish six informal palynomorph assemblage zones, labeled as zone A – zone F, based on the first and the last occurrences of two or more species. These palynomorph assemblage zones include: (1) zone A — middle Paleocene Scabratriporites simpliformis–Bombacidites annae zone; (2) zone B — late Paleocene Foveotricolporites crassiexinus–Mauritidiites crassiexinus zone; (3) zone C — early Eocene Striatopollis catatumbus–Momipites africanus zone; (4) zone D — middle Eocene Margocolporites umuahiaensis–Gemmastephanocolporites brevicolpites zone; (5) zone E — late Eocene Cicatricosisporites dorogensis–Perfotricolpites nigerianus zone; and, (6) zone F — Oligocene–early Miocene Verrucatosporites usmensis–Magnastriatites howardii zone. The erected palynozones were correlated and compared with existing biozones in subsurface, down-dip sectors of the Niger Delta Basin, with pantropical palynological zones in tropical areas of Africa, and with palynofloral provinces of northern South America. A comparison of palynozones studied in southeastern Nigeria with other international palynozones, in this study, will assist in establishing the correlation of sediments for these areas.
Comparison between RECIST and PERCIST criteria in therapeutic response assessment in cases of lymphoma
Authors: Tawfik Marwa Mohammed Hasan , Monib Ahmed Mohamed , Yassin Aya , Ali Susan Adil 
Published: May 2020

Abstract
Background
Accurate radiologic assessment of treatment response in lymphomas is important for helping the clinicians to properly evaluate effectiveness of treatment and consequently guide therapeutic management of these patients. Imaging tools based on anatomic response are suboptimal in detecting functional changes in tumors resulting after early effective treatment. Recently, with the development of 18F-FDG PET/CT, both functional and anatomic information has been integrated for assessing treatment response in both solid tumors and hematologic malignancies. The aim of this study was to compare therapeutic response in lymphoma patients using both RECIST 1.1 and PERCIST 1.0 criteria.

Results
Among the included 33 lymphoma patients, RECIST 1.1 and PERCIST 1.0 classifications of therapeutic response were concordant in 20 patients (60.6%) and discordant in 13 patients (39.4%), with a tendency of RECIST 1.1 to downgrade the tumor response in 12/13 patients (P value < 0.001).

Conclusion
The recently applied PERCIST 1.0 is efficient and more accurate than RECIST 1.1 to assess treatment response in lymphoma patients, which is subsequently affecting further management of these patients.
Symptom trajectories into eating disorders: A systematic review of longitudinal, nonclinical studies in children/adolescents
Authors: McClelland Jessica , Robinson Lauren , Potterton Rachel , Mountford Victoria , Schmidt Ulrike 
Published: May 2020

Abstract

Background.
Eating disorders (EDs) are serious mental illnesses that can be life-threatening. Stage of illness models and early intervention strategies could be informed by a better understanding of symptomatology that precedes the onset of an ED. This review aims to explore which symptoms (both ED and other psychiatric disorder-related) exist prior to the onset of an ED and whether there any prospective associations between these symptomatologies.

Methods.
A systematic literature review was conducted in MEDLINE, Embase, and PsycINFO for large, longitudinal, prospective studies in nonclinical cohorts of children/adolescents that report symptoms prior to the onset of an ED. A quality assessment of included studies was conducted using the Newcastle-Ottawa Quality Assessment Scale.

Results.
A total of 22 studies were included, and over half were assessed to be of good quality. Studies identified the presence of a broad range of ED and other psychiatric disorder-related symptoms prior to ED onset. Possible prospective associations were identified, including early eating and feeding difficulties in childhood, to ED-related symptoms (e.g., dieting and body dissatisfaction) and other psychiatric disorder-related symptoms (e.g., anxiety and depression) in childhood/early adolescence, progressing to severe symptomatology (e.g., extreme weight control behaviors and self-harm) in mid-adolescence/emerging adulthood.

Conclusion.
The trajectory of symptoms identified to precede and possibly predict onset of an ED may inform early intervention strategies within the community. Suggestions for further research are provided to establish these findings and the clinical implications of these discussed, in order to inform how best to target prodromal stages of EDs.
The application of multi-criteria decision analysis to inform in resource allocation
Authors: Schey Carina , Postma Maarten , Krabbe Paul , Medic Goran , Connolly Mark 
Published: May 2020

Background: There is a perception held by payers that orphan products are expensive. As a result, the current health technology assessment systems might be too restrictive for orphan drugs, therefore potentially denying patients access to life-saving medicines. While price is important, it should be considered in relation to a broader range of disease-related product attributes that are not necessarily considered by many health technology assessment agencies. To overcome these challenges, multi-criteria decision analysis has been proposed as an alternative to evaluate technologies. Methods: A targeted literature review was conducted to identify the most frequently cited attributes in multi-criteria decision analysis (MCDA) in rare diseases. From the leading attributes identified, we developed a multi-criteria decision analysis framework with which to aggregate the orphan drug values. We subsequently reviewed and plotted the relationship between single attributes and the average annual treatment costs for 8 drugs used in the treatment of rare endocrine diseases. The annual treatment costs were based on UK list prices for the average daily dose per patient. Results: The five most frequently mentioned attributes in the literature were as follows: Disease severity, Unmet need (or availability of therapeutic alternatives), Comparative effectiveness or efficacy, Quality of evidence and Safety & tolerability. Results from the multi-criteria decision analysis framework indicate a wide range of average annual per-patients costs for drugs intended for the same diseases, and likewise for diseases with a similar level of Disease severity. Conclusions: Multi-criteria decision analysis may offer a viable alternative to support discussion in reimbursement decisions for orphan drugs. The analyses can be used to inform investigations on the application of MCDAs in rare diseases.
Relationships between changes in uric acid parameters metabolism and parameters of immunity and microbiota in patients with neuroendocrine-immune complex dysfunction
Authors: Gozhenko Anatoliy , Smagliy Vadym , Korda Inna , Badiuk Nataliya , Zukow Walery , Kovbasnyuk Marta , Popovych Igor 
Published: May 2020

Background. Previously by screening correlation links between uricemia and uricosuria, on the one hand, and immunity and microbiota parameters, on the other, registered in patients with chronic pyelonephritis and cholecystitis in remission twice (before and after ten days of balneotherapy), we found that raw uricemia determines by 28% nine parameters of immunity as well as bacteriuria and content in E. coli feces. Uricemia, normalized by sex and age, determines by 25% another constellation of immunity parameters as well as content in E. coli feces with impaired enzymatic activity and Klebsiela&Proteus. Instead, uricosuria determines only four parameters of immunity and only by 11,5%. The purpose of this study is to analyze the correlation between individual changes in the two parameter sets caused by balneotherapy. Material and Methods. The object of observation were 34 men and 10 women aged 24-70 years old, who came to the Truskavets’ spa for the rehabilitation treatment of chronic pyelonephritis combined with cholecystitis in remission. The serum and daily urine levels of the uric acid by uricase method were determined. Immune status evaluated on a set of I and II levels recommended by the WHO. The condition of microbiota is evaluated on the results of sowing of feces and urine. Results. It is found that individual changes in uricemia correlate inversely with changes in the level of T-helpers in blood as well as IgA and IgS in saliva while positively with changes in the level of Monocytes with the almost same force as their static levels. Instead, inverse links with changes in inflammatory markers and positive connections with changes in CIC and T-killers that are absent with respect to static parameters are revealed. However, no association was found between changes in uricemia and the intensity of Staph. aureus phagocytosis by blood neutrophils. Changes in uricosuria correlate with changes in only three immune parameters, and even at the limit of significance. Taking into account other relationships, we find that balneotherapy-induced changes in uricemia and uricosuria determine changes in immune status by 60%. Conclusion. Endogenous uric acid has a modulating effects on a number of immune parameters in patients with neuroendocrine-immune complex dysfunction on background of chronic inflammatory diseases.
Features of the HRV, endocrine and metabolic parameters in persons whose immune status is susceptible or resistant to chronic stress
Authors: Lukyanchenko Oleksandr , Mel’nyk Oksana , Gozhenko Olena , Zukow Walery , Popovych Igor 
Published: May 2020

Background. In the previous studies, we compared the individuals who were almost identical to the average value of LF/HF ratio and its dispersion, but with opposite deviations from the norm of immunity. Two profiles of EEG have been created that reflect the differences between the two clusters. The first profile contains the parameters that in stress-sensitive individuals are in the zone of narrowed norm, whereas in stress-resistant individuals they are to some degree elevated, or at least exceed those in stress-sensitive individuals. The second profile contains EEG parameters, each of which in stress-resistant individuals is lower than that of stress-sensitive individuals. The purpose of this study is to clarify the features of the HRV, endocrine and metabolic parameters in persons whose immune status is susceptible or resistant to chronic stress. Materials and Methods. The object of observation were 32 men and 8 women with chronic pyelonephritis in remission. The criterion for inclusion was the magnitude of the sympathico-vagal balance index LF/HF which exceeded the age norm by 0,5 σ. We determined spectral parameters of HRV, plasma levels of principal adaptation Hormones, plasma and daily urine levels of the Electrolytes and Nitrous metabolites as well as plasma Lipoproteines spectrum. Results. Discriminant analysis revealed that Testosterone is the main factor that conditioning the sensitivity of immune status to sympathotonic shift in autonomic regulation in chronic stress. Sensitizing (immunosuppressive) factors are also Ca/K-ratio of plasma and total Cholesterol, instead LD LP Cholesterol, Creatininuria, P/Ca-ratio of urine, spectral power of VLF band HRV as well as entropy of HRV are desensitizing (immunoprotective) factors. Conclusion. The susceptibility or resistance of the immune status to the stress sympathotonic shift of autonomic regulation is conditioned by the combination of EEG, HRV, endocrine and metabolic parameters.
Correlation between temporomandibular joint dysfunction and Eichner classification
Authors: Krzewski Szymon , Baranowski Mateusz , Zubrzycki Robert , Stachurski Maciej , Borowicz Janusz 
Published: May 2020

Introduction: The Dental Prosthetics Department's most common patients are elderly who have lost their teeth. Dental deficiencies not only impair the functions of the stomatognathic system but can also be the cause of temporomandibular disorders (TMD). Deficiencies in the lateral sections lead to a decrease in the occlusion height in patients, which negatively affects the aesthetics of the face by shortening the lower floor and overloading the remaining teeth, eventually leading to their pathological wear. Loss of occlusion height changes the spatial arrangement of the lower jaw to the upper jaw, which can lead to changes in the temporomandibular joint. The loss of a tooth or group of teeth is an indication for proper prosthetic treatment. The dentist should be able to take into account, evaluate and, if necessary, cure TMD, but this is not a common skill among dentists. Such treatment requires an appropriate comprehensive approach. There are currently no standards for such treatment. We presented one of the methods as part of our study.Purpose of work:The aim of the study was to check the correlation between the occurrence of temporomandibular disorders and missing teeth and used prosthetic restorations. Material and methods:Medical history records of 58 patients under the care of the Department of Dental Prosthetics at Medical University of Lublin were analyzed. Factors such as age and gender, occlusion height, distribution of missing teeth according to the Eichner classification and symptoms of temporomandibular joint disorders, i.e. crackling, pain, limited and excessive abduction of the jaw were checked. Before starting prosthetic treatment, every patient underwent comprehensive conservative, surgical and periodontics treatment in accordance with existing needs. Results:The study group consisted of 38 women and 20 men. The average age of all patients was 69.6 years; - average for men - 70.45 years, women 68.16 years. The oldest patient was an 88-year-old man, and the youngest was a 43-year-old woman. 31% of patients were toothless. 25.9% of patients had pain within the stomatognathic system, of which 86.7% were women and 13.3% men. Relaxation splint was made in 24.1% of patients.Summary:The study showed that the ailments associated with the stomatognathic system are correlated with a reduction in occlusion height. Larger dental deficits are more common in older people. Pain symptoms are the most common cause of making relaxation splints. Women more often than men complain of pain. The correct treatment scheme for patients with missing teeth and long-term loss of support zones is staggered treatment - two-stage. The first stage of treatment is to restore the correct occlusion height by using the occlusal splint. Then, after the adaptation period, there is a transition to the second stage of treatment - the use of proper prosthetic restoration maintaining the correct height of occlusion
Photon quantification in Ho3+/Yb3+ co-doped opto-thermal sensitive fluotellurite glass phosphor
Authors: Yang J. X. , Li D. S. , Li G. , Pun E. Y. B. , Lin H. 
Published: May 2020

Multi-photon-excited thermal-correlated green and red upconversion (UC) emissions have been quantified in

H
o

3
+

/

Y
b

3
+

co-doped fluotellurite (BZLFT) glass phosphor under the 978 nm laser excitation. The temperature dependence of the fluorescence intensity ratio (FIR) originated from UC emissions bands centered at 550 nm and 661 nm has been verified in the range of 303−543 K. The net emission photon numbers of

5

F

4

+
5

S

2

→

5

I

8

and

5

F

5

→

5

I

8

transition emissions are up to

40.08

×

10

12

and

68.51

×

10

12

c
p
s

in the

0.4

w
t

.

%

H
o

2

O

3

−

0.4

w
t

.

%

Y
b

2

O

3

co-doped BZLFT case under the

6.95

W

/

m
m

2

laser power density. Furthermore, the quantum yield (QY) and luminous flux are determined to be dependent on pumping power. When the excitation power increases 874 mW, the QY values for 550 nm and 661 nm emissions are as high as

0.94

×

10

−
5

and

1.60

×

10

−
5

.

In addition, the high photon producing efficiency is conducive to ensuring high feedback to thermosensitive performance. The temperature thermal sensor can be manipulated steadily in medium temperature range, and the relative sensitivity reaches

0.4

%

K

−
1

at 303 K, which is 1 order of magnitude larger than those in several rare-earth-doped materials. Efficient photon conversion ability and high temperature sensitivity indicate that the rare-earth-ion-doped fluotellurite material has a prospective application in the construction of optical temperature sensors based on the FIR technique allowing for self-referenced temperature determination.