bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patients' perspectives on a new delivery model in primary care: A propensity score matched analysis of patient‐reported outcomes in a Dutch cohort study
Authors: van den Bogaart Esther H. A. , Spreeuwenberg Marieke D. , Kroese Mariëlle E. A. L. , van Hoof Sofie J. M. , Hameleers Niels , Ruwaard Dirk 
Published: June 2020

AbstractRationale, aims and objectivePrimary Care Plus (PC+) focuses on the substitution of hospital‐based medical care to the primary care setting without moving hospital facilities. The aim of this study was to examine whether population health and experience of care in PC+ could be maintained. Therefore, health‐related quality of life (HRQoL) and experienced quality of care from a patient perspective were compared between patients referred to PC+ and to hospital‐based outpatient care (HBOC).MethodsThis cohort study included patients from a Dutch region, visiting PC+ or HBOC between December 2014 and April 2018. With patient questionnaires (T0, T1 and T2), the HRQoL and experience of care were measured. One‐to‐two nearest neighbour calliper propensity score matching (PSM) was used to control for potential selection bias. Outcomes were compared using marginal linear models and Pearson chi‐square tests.ResultsOne thousand one hundred thirteen PC+ patients were matched to 606 HBOC patients with well‐balanced baseline characteristics (SMDs <0.1). Regarding HRQoL outcomes, no significant interaction terms between time and group were found (P > .05), indicating no difference in HRQoL development between the groups over time. Regarding experienced quality of care, no differences were found between PC+ and HBOC patients. Only travel time was significantly shorter in the HBOC group (P ≤ .001).ConclusionResults show equal effects on HRQoL outcomes over time between the groups. Regarding experienced quality of care, only differences in travel time were found. Taken as a whole, population health and quality of care were maintained with PC+ and future research should focus more on cost‐related outcomes.
Fluency in Dialogue: Turn‐Taking Behavior Shapes Perceived Fluency in Native and Nonnative Speech
Authors: van Os Marjolein , de Jong Nivja H. , Bosker Hans Rutger 
Published: June 2020

AbstractFluency is an important part of research on second language learning, but most research on language proficiency typically has not included oral fluency as part of interactions even though natural communication usually occurs in conversations. The present study considered aspects of turn‐taking behavior as part of the construct of fluency and investigated whether these aspects differentially influence perceived fluency ratings of native and nonnative speech. Results from two experiments using acoustically manipulated speech showed that, in native speech, too “eager” answers (interrupting a question with a fast answer) and too “reluctant” answers (answering slowly after a long turn gap) negatively affected fluency ratings. However, in nonnative speech, only too “reluctant” answers led to lower fluency ratings. Thus, we demonstrated that acoustic properties of dialogue are perceived as part of fluency. By adding to the current understanding of dialogue fluency, these lab‐based findings carry implications for language teaching and assessment.
“We are being made the victims of our own metaphors”: Language acquisition and streams of suppositions in May Sinclair's Mary Olivier: A Life (1919)
Authors: de Bont Leslie 
Published: June 2020

AbstractThis paper revisits Sinclair's use of stream of consciousness techniques as a means to explore Mary Olivier's psycholinguistic development. Sinclair's pre‐, para‐ and metalinguistic versions of the stream of consciousness provide a complex, fictional response to one of her earlier philosophical discussions of “the limitations of language” (1917, p. 346), which stressed the lack of fit between the way other theorists defined the term “consciousness” and her personal understanding of the concept. Mary Olivier's complex acquisition, appropriation, exploration and deconstruction of language also shed light on Sinclair's idiosyncratic integration of psychology, philosophy and feminism into her fiction and thus appears as a distinctive and hybrid feature of this modernist Bildungsroman.
Impedance in the evaluation of the esophagus
Authors: Wu Peter I. , Sloan Joshua A. , Kuribayashi Shiko , Gregersen Hans 
Published: June 2020

AbstractThe aim of this paper is to review esophageal electrical impedance technologies and to discuss the use of these technologies for physiological measurements, diagnostics, and therapy of esophageal disease. In order to develop a better understanding of the pathophysiology of and improve the diagnosis of esophageal disorders, such as gastroesophageal reflux disease (GERD) and achalasia, several new diagnostic tests, including intraluminal impedance, esophageal mucosal impedance, and the functional luminal imaging probe, have been developed. These technologies have proven valuable for assessment of the esophagus in recent years. They provide information on esophageal flow properties, mucosal integrity, lumen shape, and distensibility in esophageal disorders, in particular for GERD and achalasia. Despite their promise and novel clinical studies, the potential of these technologies has been far from realized. New multidisciplinary approaches will contribute to our understanding and interpretation of esophageal impedance data and disease mechanisms.
Association of self‐reported religiosity with the development of major depression in multireligious country Japan
Authors: Kobayashi Daiki , First Michael B. , Shimbo Takuro , Kanba Shigenobu , Hirano Yoji 
Published: June 2020

AimIn Western Christian countries, religiosity is generally believed to be associated with a lower risk for depression, which is supported by epidemiological evidence. However, the association between religiosity and depression in multireligious countries is unknown. The objective was to evaluate the association between religiosity and subsequent depression in a multireligious population.MethodsA longitudinal study was conducted in a large hospital in Tokyo, Japan, from 2005 to 2018. All participants who underwent health check‐ups without a prior history of depression or depression at baseline were included. Our outcome was development of major depressive disorder (MDD), which was compared according to the degree of religiosity, adjusting for potential confounders.ResultsAmong 67 723 adult participants, those who were more religious tended to be older, female, married, and to have healthier habits but also more medical comorbidities at baseline. During a median follow‐up of 2528 days, 1911 (2.8%) participants developed MDD. Compared to the reference group, religious group participants tended to have higher odds ratios (OR) for developing MDD in a dose‐dependent manner. Among them, the extremely religious group (OR, 1.51; 95% confidence interval [CI], 1.28–1.78) and the moderately religious group (OR, 1.30; 95% CI, 1.14–1.49) were statistically associated with increased development of MDD compared to the not‐religious‐at‐all group. Those who had increased their religiosity from baseline had statistically lower development of MDD (OR, 0.85; 95% CI, 0.75–0.97) compared to those who remained in the same degree of religiosity from baseline.ConclusionReligiosity was associated with future MDD in a dose‐dependent manner in a multireligious population, which was in the opposite direction from that seen in previous Western longitudinal studies.
Secondary origin, hybridization and sexual reproduction in a diploid–tetraploid contact zone of the facultatively apomictic orchid Zygopetalum mackayi
Authors: Moura Y. A. , Alves‐Pereira A. , da Silva C. C. , Souza L. M. , de Souza A. P. , Koehler S. 
Published: June 2020

Abstract

The production of triploids and apomictic reproduction are important processes for polyploid establishment and cytotype coexistence, but we know little about the interaction between triploids and facultatively apomictic plants. To bridge this gap, we studied the pollen‐dependent, facultatively apomictic orchid Zygopetalum mackayi from high‐elevation outcrops of southeast Brazil.

We described the nature of the contact between Z. mackayi cytotypes and patterns of genetic diversity and structure based on eight microsatellite markers and 155 individuals of pure tetraploid, pure diploid and mixed cytotype populations.

Our results revealed high values of genetic and genotypic diversity within all populations of Z. mackayi. Each cytotype emerged as a genetic distinct cluster, combining individuals from different populations. Triploids clustered in an intermediate position between diploids and tetraploids. Most genetic variance is associated with individuals within populations and genetic differentiation is high among populations.

Mixed cytotype populations of Z. mackayi originate from secondary contact. Triploids are hybrids between diploids and tetraploids and likely act as a bridge. Our results point to the predominance of sexual reproduction in all populations but do not corroborate previous basic chromosome number for this species. Polyploidy rather than facultative apomixis may explain the larger geographic distribution of tetraploids of Z. mackayi.
Erzählungen des Kindes‐ und Erwachsenenschutzes: Eine Anwendung und Erweiterung desNarrative Policy Frameworks
Authors: Hildbrand Leandra , Stauffer Bettina , Sager Fritz , Kuenzler Johanna 
Published: June 2020

AbstractThe Child and Adult Protection Authorities (KESB) have been the subject of controversial discussion since their establishment in 2013. The reform of the Guardianship Law provided for an institutional shift away from local guardianship authorities to regional specialist authorities. This article uses the Narrative Policy Framework (NPF) to examine the history of today’s controversy, simultaneously proposing an analytic strengthening of said framework. Previous NPF studies summarize policy actors into opponents and proponents. As a result, we do not know whether different actors use different narratives. We therefore separate the expert from the MP discourse. The analysis shows that the experts' arguments for a new institutional arrangement and a person‐oriented narrative dominated, which put the fundamental rights of the persons affected by guardianship measures up front. The study contributes to the understanding of the current controversy, in which a person‐oriented narrative seems to be dominant again, directed against the new authorities.
Treatment outcomes and target delineation utilizingCTandMRIin 13 dogs treated with a uniform stereotactic radiation therapy protocol (16 Gy single fraction) for pituitary masses: (2014‐2017)
Authors: Gieger Tracy L. , Nolan Michael W. 
Published: June 2020

AbstractCanine pituitary tumours are increasingly treated with stereotactic radiotherapy (SRT). Here, we report clinical outcomes in dogs treated with single‐fraction SRT; we also explore technical aspects of SRT treatment planning. A single‐institution retrospective study was performed, including any dog with a pituitary mass (PM) that was treated using a standardized single‐fraction (16 Gy) SRT protocol between 2014 and 2017. Via medical records review, 13 cases were identified. Nine dogs neurologically improved after SRT. Four dogs experienced MRI‐documented tumour volume reduction. Nine dogs experienced neurologic decline in 1.5 to 18 months after SRT and were euthanized. The median overall survival time was 357 days, with 15% alive 18 months after SRT. To better understand whether SRT target delineation is predictably altered by use of magnetic resonance imaging (MRI) in addition to computed tomography (CT), two radiation oncologists (RO) retrospectively re‐evaluated all imaging studies used for SRT planning in these 13 cases. Gross tumour volume (GTV) was contoured on co‐registered CT and MRIs for each case. In seven cases, CT alone was deemed inadequate for GTV contouring by at least one RO. T1 post‐contrast MRI was considered the ideal image for GTV contouring in 11 cases. Contouring on MRI yielded larger GTV than CT for 11 cases. Inter‐observer variability existed in each case and was greater for MRI. In summary, use of co‐registered CT and MRI images is generally considered advantageous for PM delineation when using SRT. Notably, survival times reported herein are shorter than what has previously been reported for PM treated with finely fractionated full‐course RT protocols.
Semihyper-Reduction for Finite Element Structures With Nonlinear Surface Loads on the Basis of Stress Modes
Authors: Koller Lukas , Witteveen Wolfgang , Pichler Florian , Fischer Peter 
Published: June 2020

Abstract
Model reduction via projection is a common method to accelerate time integration of finite element (FE) structures by reducing the number of degrees-of-freedom (DOFs). However, nonlinear state-dependent surface loads are usually computed based on the nonreduced DOFs of the FE model. When a considerably high number of DOFs are involved in the nonlinear surface loads, their computation becomes a bottleneck. This paper presents a general approach for reduced time integration and reduced force computation for FE models. The required force trial vectors can be computed easily and systematically out of deformation trial vectors, commonly called “modes.” Those force trial vectors, which we call “stress modes,” can be determined a priori so that a nonlinear computation of the full system is not necessary. The new idea in this contribution is that stress recovery is used to decrease the number of equations for the force computation. A general framework for semihyper-reduction (SHR) is developed and its practical implementation is discussed. The term SHR is introduced because it is an intermediate approach between the straight-forward method of using the FE DOFs and pure hyper-reduction (HR) where the FE DOFs are omitted for computing state-depended surface loads. In order to demonstrate the proposed SHR approach practically, a numerical example of a planar crank drive is given, where a hydrodynamic lubrication film separates piston and cylinder. Thereby, very good result quality has been observed in comparison to a finite difference reference solution.
A Coarea Formulation for Grid-Based Evaluation of Volume Integrals
Authors: Uchytil Christopher , Storti Duane 
Published: June 2020

Abstract
We present a new method for computing volume integrals based on data sampled on a regular Cartesian grid. We treat the case where the domain is defined implicitly by an inequality, and the input data include sampled values of the defining function and the integrand. The method employs Federer’s coarea formula (Federer, 1969, Geometric Measure Theory, Grundlehren der mathematischen Wissenschaften, Springer) to convert the volume integral to a one-dimensional quadrature over level set values where the integrand is an integral over a level set surface. Application of any standard quadrature method produces an approximation of the integral over the continuous range as a weighted sum of integrals over level sets corresponding to a discrete set of values. The integral over each level set is evaluated using the grid-based approach presented by Yurtoglu et al. (2018, “Treat All Integrals as Volume Integrals: A Unified, Parallel, Grid-Based Method for Evaluation of Volume, Surface, and Path Integrals on Implicitly Defined Domains,” J. Comput. Inf. Sci. Eng., 18, p. 3). The new coarea method fills a need for computing volume integrals whose integrand cannot be written in terms of a vector potential. We present examples with known results, specifically integration of polynomials over the unit sphere. We also present Saye’s (2015, “High-Order Quadrature Methods for Implicitly Defined Surfaces and Volumes in Hyperrectangles,” SIAM J. Sci. Comput., 37) example of integrating a logarithmic integrand over the intersection of a bounding box with an open domain implicitly defined by a trigonometric polynomial. For the final examples, the input data is a grid of mixture ratios from a direct numerical simulation of fluid mixing, and we demonstrate that the grid-based coarea method applies to computing volume integrals when no analytical form of the implicit defining function is given. The method is highly parallelizable, and the results presented are obtained using a parallel implementation capable of producing results at interactive rates.
Are we missing the target? Are we aiming too low? What are the aerobic exercise prescriptions and their effects on markers of cardiovascular health and systemic inflammation in patients with knee osteoarthritis? A systematic review and meta-analysis
Authors: Schulz Jenna M , Birmingham Trevor B , Atkinson Hayden F , Woehrle Emilie , Primeau Codie A , Lukacs Michael J , Al-Khazraji Baraa K , Khan Michaela C M , Zomar Bryn O , Petrella Robert J , Beier Frank , Appleton C Thomas , Shoemaker J Kevin , Bryant Dianne M 
Published: June 2020

ObjectivesWe systemically reviewed published studies that evaluated aerobic exercise interventions in patients with knee osteoarthritis (OA) to: (1) report the frequency, intensity, type and time (FITT) of exercise prescriptions and (2) quantify the changes in markers of cardiovascular health and systemic inflammation.Data sourcesPubMed, CINAHL, Scopus; inception to January 2019.Eligibility criteriaRandomised clinical trials (RCT), cohort studies, case series.DesignWe summarised exercise prescriptions for all studies and calculated effect sizes with 95% CIs for between-group (RCTs that compared exercise and control groups) and within-group (pre-post exercise) differences in aerobic capacity (VO2), heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and inflammatory markers (interleukin-6 (IL-6), tumour necrosis factor-alpha). We pooled results where possible using random effects models.ResultsInterventions from 49 studies were summarised; 8% (4/49) met all FITT guidelines; 16% (8/49) met all or most FITT guidelines. Fourteen studies (10 RCTs) reported at least one marker of cardiovascular health or systemic inflammation. Mean differences (95% CI) indicated a small to moderate increase in VO2(0.84 mL/min/kg; 95% CI 0.37 to 1.31), decrease in HR (−3.56 beats per minute; 95% CI −5.60 to −1.52) and DBP (−4.10 mm Hg; 95% CI −4.82 to −3.38) and no change in SBP (−0.36 mm Hg; 95% CI −3.88 to 3.16) and IL-6 (0.37 pg/mL; 95% CI −0.11 to 0.85). Within-group differences were also small to moderate.ConclusionsIn studies of aerobic exercise in patients with knee OA, very few interventions met guideline-recommended dose; there were small to moderate changes in markers of cardiovascular health and no decrease in markers of systemic inflammation. These findings question whether aerobic exercise is being used to its full potential in patients with knee OA.PROSPERO registration numberCRD42018087859.
Non-absorbable versus absorbable sutures for anterior colporrhaphy: study protocol for a randomised controlled trial in South Korea
Authors: Jeon Myung Jae , Suh Dong Hoon , Kim Chul Hong , Cho Hyun-Hee , Shin Jung-Ho , Lee Sa Ra , Jung Yong Wook , Kim Soo Rim , Kong Mi Kyung 
Published: June 2020

IntroductionThe anterior vaginal wall is the segment most commonly affected by prolapse. Traditionally, anterior vaginal wall prolapse is repaired via anterior colporrhaphy, which is known to have a high recurrence rate. Several factors might affect the outcome of anterior colporrhaphy, and the use of absorbable sutures might also be associated with the high recurrence rate because the sutures might not be able to retain adequate strength until the plicated pubocervical fascia remodels and regains maximum tensile strength. Nonetheless, no comparative data exist about the relative efficacy and safety of anterior colporrhaphy using non-absorbable versus absorbable sutures. The objective of this study is to compare the surgical outcomes of anterior colporrhaphy using non-absorbable sutures with those of anterior colporrhaphy using absorbable sutures.Methods and analysisThis is a randomised, multicentre, superiority trial. Anterior colporrhaphy will be performed in a traditional manner with midline plication of the fibromuscular layer using either non-absorbable or absorbable sutures. The primary outcome is composite surgical success 1 year after surgery defined as the absence of all of the following: (1) anterior vaginal descent beyond the hymen, (2) the presence of vaginal bulge symptoms and (3) retreatment for recurrent anterior vaginal wall prolapse with either surgery or pessary. The secondary outcomes include the individual components of the composite primary end point, anatomical outcomes, condition-specific quality of life and adverse events related to anterior colporrhaphy. The planned number of participants is 192.Ethics and disseminationThis study was approved by the Institutional Review Board of Seoul National University Hospital (H-1810-037-977). The results of the study will be published in peer-reviewed journals, and the findings will be presented at scientific meetings.Trial registration numberNCT03736811
Effectiveness of cervical pessary compared to cervical cerclage with or without vaginal progesterone for the prevention of preterm birth in women with twin pregnancies and a short cervix: study protocol for a two-by-two factorial randomised clinical trial
Authors: Dang Vinh Q , He Yen TN , Pham Ha NH , Trieu Tuyen TT , Bui Trung Q , Vuong Nhu T , Nguyen Loc MT , Nguyen Diem TN , Le Thanh V , Li Wentao , Le Cam H , Mol Ben W , Vuong Lan N 
Published: June 2020

IntroductionWomen with twin pregnancies and a short cervix are at increased risk for preterm birth (PTB). Given the burden of prematurity and its attendant risks, the quest for effective interventions in twins has been an area of considerable research. Studies investigating the effectiveness of cervical cerclage, cervical pessary and vaginal progesterone in preventing PTB have yielded conflicting results. The aim of this study is to compare the effectiveness of cervical pessary and cervical cerclage with or without vaginal progesterone to prevent PTB in women with twin pregnancies and a cervical length (CL) ≤ 28 mm.Methods and analysisThis multicentre, randomised clinical trial will be conducted at My Duc Hospital and My Duc Phu Nhuan Hospital, Vietnam. Asymptomatic women with twin pregnancies and a CL ≤28 mm, measured at 16–22 weeks’ gestation, will be randomised in a 1:1:1:1 ratio to receive a cerclage, pessary, cerclage plus progesterone or pessary plus progesterone. Primary outcome will be PTB <34 weeks. Secondary outcomes will be maternal and neonatal complications. We preplanned a subgroup analysis according to CL from all women after randomisation and divided into four quartiles. Analysis will be conducted on an intention-to-treat basis. The rate of PTB <34 weeks’ gestation in women with twin pregnancies and a cervix ≤28 mm and treated with pessary in our previous study at My Duc Hospital was 24.2%. A sample size of 340 women will be required to show or refute that cervical cerclage decreases the rate of PTB <34 weeks by 50% compared with pessary (from 24.2% to 12.1%, α level 0.05, power 80%, 5% lost to follow-up and protocol deviation). This study is not to be powered to assess interactions between interventions.Ethics and disseminationEthical approval was obtained from the Institutional Ethics Committee of My Duc Hospital and informed patient consent was obtained before study enrolment. Results of the study will be submitted for publication in a peer-reviewed journal.Trial registration numberNCT03863613 (date of registration: 4 March 2019).