bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of the trajectory uniformity in water dissolution ultraprecision continuous polishing of large-sized KDP crystal
Authors: Cheng Zhipeng , Gao Hang , Liu Ziyuan , Guo Dongming 
Published: September 2020

Abstract
Large-sized potassium dihydrogen phosphate (KDP) crystals are an irreplaceable nonlinear optical component in an inertial confinement fusion project. Restricted by the size, previous studies have been aimed mainly at the removal principle and surface roughness of small-sized KDP crystals, with less research on flatness. Due to its low surface damage and high machining efficiency, water dissolution ultraprecision continuous polishing (WDUCP) has become a good technique for processing large-sized KDP crystals. In this technique, the trajectory uniformity of water droplets can directly affect the surface quality, such as flatness and roughness. Specifically, uneven trajectory distribution of water droplets on the surface of KDP crystals derived from the mode of motion obviously affects the surface quality. In this study, the material removal mechanism of WDUCP was introduced. A simulation of the trajectory of water droplets on KDP crystals under different eccentricity modes of motion was then performed. Meanwhile, the coefficient of variation (CV) was utilized to evaluate the trajectory uniformity. Furthermore, to verify the reliability of the simulation, some experimental tests were also conducted by employing a large continuous polisher. The results showed that the CV varied from 0.67 to 2.02 under the certain eccentricity mode of motion and varied from 0.48 to 0.65 under the uncertain eccentricity mode of motion. The CV of uncertain eccentricity is always smaller than that of certain eccentricity. Hence, the uniformity of trajectory was better under uncertain eccentricity. Under the mode of motion of uncertain eccentricity, the initial surface texture of the 100 mm × 100 mm × 10 mm KDP crystal did achieve uniform planarization. The surface root mean square roughness was reduced to 2.182 nm, and the flatness was reduced to 22.013 μm. Therefore, the feasibility and validity of WDUCP for large-sized KDP crystal were verified.
Understanding and identifying ways to improve hospital-based cancer care and treatment for people with dementia: an ethnographic study
Authors: Ashley Laura , Kelley Rachael , Griffiths Alys , Cowdell Fiona , Henry Ann , Inman Hayley , Hennell June , Ogden Margaret , Walsh Maria , Jones Liz , Mason Ellen , Collinson Michelle , Farrin Amanda , Surr Claire 
Published: September 2020

Abstract

Background
Providing cancer care and treatment for ageing populations with complicating comorbidities like dementia is a growing global challenge. This study aimed to examine the hospital-based cancer care and treatment challenges and support needs of people with dementia, and identify potential ways to address these.

Methods
A two-site ethnographic study in England involving semi-structured interviews, observations and accompanying conversations, and medical record review. Participants (N = 58) were people with dementia and comorbid cancer (n = 17), informal caregivers (n = 22) and hospital staff (n = 19). Ethnographically informed thematic analysis was conducted.

Results
There was an accumulated complexity of living with both illnesses simultaneously. People with dementia and families could feel confused and uninformed due to difficulties understanding, retaining and using cancer information, which impacted their informed treatment decision-making. Dementia increased the complexity and burden of travelling to and navigating unfamiliar hospital environments, frequent lengthy periods of waiting in hospital, and self-managing symptoms and side-effects at home. Oncology staff were often working without the full picture, due to variable documenting of dementia in medical records, dementia training was limited, and time and resource pressures impeded the highly individualised, flexible cancer care required by people with dementia. Supportive family carers were crucial in enabling people with dementia to access, navigate and undergo cancer treatment and care.

Conclusions
Dementia complicates cancer care in a range of ways accumulating across the cancer pathway. Our findings suggest there are several strategies and interventions, which we list here, with potential to improve cancer care and treatment for people with dementia and their families.
Creation and maintenance of a table for assessment of evolving evidence for COVID-19–related treatments
Authors: Snow Elaine K , Miller Jane L , Kester Linda , Mendham Natalie A , Heydorn Joan D , Huang Shingyee Cindy , Leu Lily L , Kohoutek Lisa M , Rosanelli Natalie C , Harves Kaitlin M 
Published: September 2020

Abstract

Purpose
This report describes the development and maintenance of a table to present an assessment of evidence for treatments used in patients with coronavirus disease 2019 (COVID-19).

Summary
AHFS Drug Information (AHFS DI) (American Society of Health-System Pharmacists, Bethesda, MD) is ASHP’s evidence-based drug compendium that contains drug monographs written for pharmacists and other healthcare professionals. The professional editorial and analytical staff of pharmacists critically evaluate published evidence to develop drug monographs for AHFS DI. In response to the global COVID-19 pandemic, these skills were applied to assess emerging evidence for COVID-19–related treatments, and the information was compiled into a new resource for pharmacists and other healthcare professionals to use at the point of care. A list of therapies was developed and prioritized based on review of scientific and public discussions on the use of these therapies in patients with COVID-19; certain therapies used for supportive care and therapies that might theoretically be harmful to patients with COVID-19 also were considered for inclusion. Potential treatments were identified, and the evidence for use in patients with COVID-19 was assessed and summarized in a table format. Information presented for each therapy included the rationale for use, summaries of clinical trials or experience, trial registry numbers, and dosage regimens. Comments on safety and efficacy, including limitations of available data, were presented along with recommendations from recognized authorities. The editorial team continued to add new therapies to the table and update existing entries as new evidence emerged.

Conclusion
A comprehensive table that summarized available evidence for potential treatments for patients with COVID-19 was developed. The table format enabled the drug information editorial staff to provide ongoing updates as new information emerged during the pandemic.
VIRTUS: a pipeline for comprehensive virus analysis from conventional RNA-seq data
Authors: Yasumizu Yoshiaki , Hara Atsushi , Sakaguchi Shimon , Ohkura Naganari 
Published: September 2020

Abstract

Summary
The possibility that RNA transcripts from clinical samples contain plenty of virus RNAs has not been pursued actively so far. We here developed a new tool for analyzing virus-transcribed mRNAs, not virus copy numbers, in the data of bulk and single-cell RNA-sequencing of human cells. Our pipeline, named VIRTUS (VIRal Transcript Usage Sensor), was able to detect 762 viruses including herpesviruses, retroviruses and even SARS-CoV-2 (COVID-19), and quantify their transcripts in the sequence data. This tool thus enabled simultaneously detecting infected cells, the composition of multiple viruses within the cell, and the endogenous host-gene expression profile of the cell. This bioinformatics method would be instrumental in addressing the possible effects of covertly infecting viruses on certain diseases and developing new treatments to target such viruses.

Availability and implementation
: VIRTUS is implemented using Common Workflow Language and Docker under a CC-NC license. VIRTUS is freely available at https://github.com/yyoshiaki/VIRTUS.

Supplementary information
Supplementary data are available at Bioinformatics online.
Populism’s Attack on Multilateralism and International Law: Much Ado About Nothing*
Authors: Tladi Dire 
Published: September 2020

Abstract
While international lawyers have not traditionally paid much attention to the phenomenon of populism, a recent upswing in the populist movements in governments around the world has led to an increase in the fascination of international lawyers with populism. On the whole, there seems to be a view that populism has negatively affected the communitarianism and multilateralism of international law. This article interrogates this proposition. It comes to the conclusion that the proposition is based on an erroneous assumption about the state of international law. It concludes that populism is not a threat to international law, but that populist strategies against certain institutions and rules of international law are merely a reflection of international law’s own limitations.
Systematic Development and Validation of a RP-HPLC Method for Estimation of Abiraterone Acetate and its Degradation Products
Authors: Beg Sarwar , Malik Ankit K , Afzal Obaid , Altamimi Abdulmalik Saleh Alfawaz , Kazmi Imran , Al-Abbasi Fahad A , Almalki Waleed H , Barkat Md Abul , Kawish S M , Pradhan Debi Prasad , Rahman Mahfoozur 
Published: September 2020

Abstract
The present study described the development of a reversed-phase liquid chromatographic method for the estimation of abiraterone acetate by Quality by Design (QbD) approach. Using an isocratic solvent system for the mobile phase, the chromatographic estimation of analyte was performed on a Hypersil BDS C18 column using mobile phase mixture containing acetonitrile and water with pH adjusted with 0.1% v/v orthophosphoric acid (15:85%v/v ratio), flow rate 1.0 mL.min−1 and detection at 250 nm using photodiode array detector. Systematic development of the chromatographic method was carried out by factor screening using a half-factorial design which suggested organic modifier (%), flow rate (mL.min−1) and autosampler temperature (°C) as influential variables. Further, the method was optimized by Box–Behnken design and trials performed were evaluated for the area under peak, retention time, theoretical plate count and tailing factor as the responses. Validation of the developed method showed good linearity, accuracy, precision and sensitivity. Evaluation of the stability-indicating profile of the method using forced degradation studies revealed the formation of a possible degradation product under acidic and alkaline conditions, while no such degradation product peaks were observed under the oxidative environment. Overall, the study construed the successful development of HPLC assay method for pharmaceutical applications.
Collaborating to co-produce strategies for delivering adolescent sexual and reproductive health interventions: processes and experiences from an implementation research project in Nigeria
Authors: Mbachu Chinyere Ojiugo , Clara Agu Ifunanya , Onwujekwe Obinna 
Published: September 2020

Abstract
Implementation science embraces collaboration between academic researchers and key stakeholders/implementers for the dual purpose of capacity building and context-adaptation. Co-production ensures that knowledge created with inputs from various groups of stakeholders is more reflective of local contexts. This paper highlights the experiences of academic researchers and non-academic implementers in collaborating to design implementation strategies for improving access to sexual and reproductive information and services for adolescents. Data were collected through primary and secondary sources. Detailed review of project documents such as minutes of research meetings, reports of workshops and outputs of group work activities enabled detailed description of the processes and steps of co-designing implementation strategies. Information on experiences and perspectives of benefits of the collaborative were collected through in-depth interviews of non-academic partners and focus group discussion with academic researchers. Narrative synthesis was done for information extracted through document review. Thematic analysis of qualitative interviews was done. The process of designing implementation strategies happened in three chronological steps of setting up the collaborative, selecting intervention areas and convening partners’ meetings to design strategies. Specific activities include stakeholder engagement, situation analysis, selection of intervention areas, designing the implementation strategies and pre-testing implementation tools. The process of analysing and selecting collaborators was iterative, and facilitated by having an ‘insider’ key informant. Working with key stakeholders enabled knowledge sharing and exchange among partners. Information sharing within the collaborative facilitated shifting of mindsets about adolescent sexual and reproductive health, and contextual adaptation of names and labels given to strategies. Co-producing implementation strategies with non-academic implementers enabled stakeholder ownership of implementation strategies and set the scene for their adoption in implementation settings. Some challenges of co-production of knowledge are that it is time consuming; involves several iterations that may influence coherence of strategies; involves multiple interests and priorities and poses a threat to fidelity.
Structural valve deterioration after aortic valve replacement with the Trifecta valve
Authors: Werner Paul , Gritsch Jasmin , Scherzer Sabine , Gross Christoph , Russo Marco , Coti Iuliana , Kocher Alfred , Laufer Guenther , Andreas Martin 
Published: September 2020

Abstract

OBJECTIVES
Despite promising short- and mid-term results for durability of the Trifecta valve, contradictory reports of early structural valve deterioration (SVD) do exist. We investigated the incidence of SVD after surgical aortic valve replacement (SAVR) with the Trifecta in our single-centre experience.

METHODS
Data of 347 consecutive patients (mean age 71.6 ± 9.5 years, 63.4% male) undergoing SAVR with the Trifecta between 2011 and 2017 were analysed. Clinical and echocardiographic reports were obtained with a median follow-up of 41 months (1114 patient years).

RESULTS
Isolated SAVR was performed in 122 patients (35.2%), whereas 225 patients (64.8%) underwent concomitant procedures. The median EuroSCORE II was 4.0 (0.9; 7.1) and 30-day mortality was 3.7% (n = 13). Kaplan–Meier estimates for the freedom of overall mortality at 1, 5 and 7 years were 88.7 ± 1.7%, 73.7 ± 2.6% and 64.7 ± 4.2%, respectively. SVD was observed in 25 patients (7.2%) with a median time to first diagnosis of 73 months. Freedom of SVD was 92.5 ± 0.9% at 5 years and 65.5 ± 7.1% at 7 years. Thirteen patients underwent reintervention for SVD (6 re-SAVR, 7 valve-in-valve), resulting in a freedom of reintervention for the SVD of 98.5 ± 1.1% at 5 years and 76.9 ± 6.9% at 7 years.

CONCLUSIONS
We herein report one of the highest rates of SVD after SAVR with the Trifecta. These data indicate that the durability of the prosthesis decreases at intermediate to long-term follow-up, leading to considerable rates of reintervention due to SVD.
Aortic valve neocuspidalization in paediatric patients with isolated aortic valve disease: early experience
Authors: Polito Angelo , Albanese Sonia B , Cetrano Enrico , Cicenia Marianna , Rinelli Gabriele , Carotti Adriano 
Published: September 2020

Abstract

OBJECTIVES
There is growing interest in the aortic valve (AV) neocuspidalization technique for the treatment of aortic valve disease (AVD). We report our medium-term results with this procedure performed in a paediatric patient population.

METHODS
Between July 2016 and May 2020, 22 patients with both congenital and acquired isolated AVD were treated with neocuspidalization. The primary outcome was progression of the preoperatively assessed AVD in the immediate postoperative course and at follow-up. Secondary outcome was freedom from reintervention by material used. Potential predictors of failure were analysed in relation to the primary outcome.

RESULTS
The median age at operation was 13.9 (interquartile range, 9.8–16.2) years, and the prevailing AV defect was stenosis in 10 cases (45%) and incompetence in 12 (55%). Pre-treated autologous pericardium was used in 13 patients whereas bovine pericardium in 9. Effective treatment of AV stenosis or regurgitation was achieved and remained stable over a median follow-up of 11.3 (4.7–21) months. Three patients required AV replacement at 4.9, 3.5 and 33 months. At follow-up, an upward trend of both median indexed vena contracta jet widths and aortic peak and mean gradients were recorded, the latter associated with a failure to grow the aortic annulus. Predictor of such outcome turned out to be the use of bovine pericardium. A significant inverse linear correlation between AV peak gradient at follow-up and preoperative aortic annular size (P = 0.008) was also demonstrated.

CONCLUSIONS
The Ozaki procedure is safe and effective in paediatric patients with AV disease. The use of heterologous pericardium should probably be minimized. Moreover, preoperative small aortic annuli should probably be promptly treated by means of an associated ring enlargement procedure.
Migrants’ and Natives’ Attitudes toward Public Healthcare Provision in Denmark, Germany, and the Netherlands
Authors: Seibel Verena , Renema Jeanette A J 
Published: September 2020

AbstractPublic healthcare is still one of the main pillars of European welfare states, despite the increasing number of migrants, we know little about migrants’ attitudes toward healthcare. We used recent data from the MIFARE survey and compared natives with a variety of nine migrant groups living in Denmark, Germany, and the Netherlands, focusing on migrants’ preferred level of governmental involvement and their satisfaction with public healthcare. We found that, compared to natives, migrants held the government less responsible for providing healthcare while expressing a higher level of satisfaction. Whereas health differences among migrants and natives did not explain this ethnic gap, we found that these ethnic gaps are moderated by socialization processes and knowledge of healthcare rights.
Tiger Salamanders (Ambystoma tigrinum) Increase Foot Contact Surface Area on Challenging Substrates During Terrestrial Locomotion
Authors: Vega Christine M , Ashley-Ross Miriam A 
Published: September 2020

SynopsisAnimals live in heterogeneous environments must navigate in order to forage or capture food, defend territories, and locate mates. These heterogeneous environments have a variety of substrates that differ in their roughness, texture, and other properties, all of which may alter locomotor performance. Despite such natural variation in substrate, many studies on locomotion use noncompliant surfaces that either are unrepresentative of the range of substrates experienced by species or underestimate maximal locomotor capabilities. The goal of this study was to determine the role of forefeet and hindfeet on substrates with different properties during walking in a generalized sprawling tetrapod, the tiger salamander (Ambystoma tigrinum). Adult salamanders (n = 4, SVL = 11.2–14.6 cm) walked across level dry sand (DS), semi-soft plaster of Paris (PoP), wet sand (WS), and a hard, noncompliant surface (table)—substrates that vary in compliance. Trials were filmed in dorsal and anterior views. Videos were analyzed to determine the number of digits and surface area of each foot in contact with the substrate. The surface area of the forelimbs contacting the substrate was significantly greater on DS and PoP than on WS and the table. The surface area of the hindlimbs contacting the substrate was significantly greater on DS than on all other substrates. There were no significant differences in the time that the fore- or hindfeet were in contact with the substrate as determined by the number of digits. We conclude that salamanders modulate the use of their feet depending on the substrate, particularly on DS which is known to increase the mechanical work and energy expended during locomotion owing to the fluid nature of its loose particles. More studies are needed to test a wider range of substrates and to incorporate behavioral data from field studies to get a better understanding of how salamanders are affected by different substrates in their natural environment.
Differential antibiotic dosing in critical care: survey on nurses’ knowledge, perceptions and experience
Authors: Fawaz Sarah , Barton Stephen , Whitney Laura , Nabhani-Gebara Shereen 
Published: September 2020

Abstract

Background
With the discovery of new antibiotics diminishing, optimizing the administration of existing antibiotics has become a necessity. Critical care nurses play a crucial role in combating antimicrobial resistance and are involved in preparing and administering antibiotics as well as monitoring their effects on patients. A dosing strategy proposed to reduce the development of ever-evolving antimicrobial resistance involves differential dosing regimens such as prolonged/continuous infusions.

Objectives
To assess critical care nurses’ knowledge, perceptions, comfort and experience in relation to prolonged/continuous infusion antibiotics.

Methods
A descriptive cross-sectional study was conducted using an investigator-developed, self-administered survey consisting of open- and closed-ended questions. Obtained data were computed using SPSS. Descriptive and inferential statistics were used to analyse the data.

Results
Fifty-two critical care nurses participated in the survey. Data revealed that nurses have adequate levels of knowledge and comfort relating to the use of prolonged/continuous infusion antibiotics along with the ability to communicate effectively on the topic. Results indicate there is a need for further learning, especially in terms of multiplicity of methods for preparing and administering prolonged/continuous infusions and dose calculations. Overall, results are promising as nurses support the wider implementation of prolonged/continuous infusion treatment regimens in critical care.

Conclusion
Although critical care nurses had a good understanding surrounding the use of prolonged/continuous infusion antibiotics, there is a need for further learning beyond information gained from nursing education courses. Findings from this study indicate that nurses are supportive of prolonged/continuous infusion antibiotics. However, further research is needed to determine the most effective mode of antibiotic administration.