bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing a tool to assess institutional readiness to conduct knowledge translation activities in low-and middle-income countries
Authors: Kalbarczyk Anna , Rao Aditi , Alonge Olakunle O 
Published: August 2020

Abstract
Background

Academic institutions are well-poised to conduct knowledge translation (KT) but face many barriers, particularly in low resource settings where the need is greatest. Assessing the readiness of academic institutions to conduct KT can help our understanding of these barriers. However, limited research has been conducted to understand influencers of readiness for KT in low- and middle-income countries (LMICs) and there are no tools for KT readiness assessment designed for LMIC contexts. This paper describes the development of a tool for assessing organizational readiness to conduct KT among academic institutions in LMICs.
Methods

A literature review and stakeholder consultation process was conducted to identify constructs and items relevant for assessing KT readiness in LMICs. These were face validated with LMIC stakeholders and organized into a questionnaire measured on a Likert scale. A quantitative survey was conducted and the questionnaire distributed to faculty based at 6 LMIC academic institutions, as well as members of a global knowledge-to-action thematic working group. An exploratory factor analysis (EFA) was used to identify underlying dimensions of a tool for assessing institutional readiness to conduct KT.
Results

A total of 111 respondents with varied KT experiences from 10 LMICs (including Bangladesh, Ethiopia, DR Congo, India, Indonesia, Nigeria) were included in the analysis. We selected five factors and 23 items, with factor loadings ranging from 0.40 to 0.77. The five factors include 1) institutional climate, 2) organization change efficacy, 3) prioritization and cosmopolitanism, 4) self-efficacy, and 5) financial resources. These five factors accounted for 69% of the total variance, with Cronbach’s alpha coefficients of 0.78, 0.73, 0.62, 0.68, and 0.52, respectively.
Conclusions

This study identify a tool for assessing readiness of LMIC academic institutions to conduct KT, and unique opportunities for building capacity among academic institutions for KT. The organizational focus of these factors underscores the need for strategies that address organizational systems and structures in addition to individual knowledge, skills, and tools. Future research will be conducted to understand determinants of these factors and develop a comprehensive set of capacity building strategies responsive to academic institutions in LMICs.
Novel EPHB4 mutation in capillary malformation-arteriovenous malformation syndrome 2 (CM-AVM2): the first genetic study in Asians
Authors: Li Yuanbo , Sun Yi , Zeng Xiaojing , Liu Yun , Liu Fatao , Lin Xiaoxi , CAI Ren , Chen Hui 
Published: August 2020

Abstract
Capillary malformation-arteriovenous malformation syndrome (CM-AVM), a rare vascular malformation, is autosomal dominant and characterized by hereditary capillary malformations (CMs) and potential fast-flow vascular malformation underlying CMs in around one-third of patients, affecting approximately 0.3-0.5% of newborns. CM-AVM was first discovered in association with germline RASA-1 mutation and termed CM-AVM type 1 in 2003. Later, germline EPHB4 mutations were detected in RASA-1-negative CM-AVMs, also known as CM-AVM type 2. Although there have been recent genetic studies confirming the molecular basis of CM-AVM, few have focused on Asian populations, leading to the lack of comprehensive molecular profiling. In this study, we report a female patient diagnosed as CM-AVM2 with a novel stop-gain mutation causing loss of function of the EPHB4 gene. As far as we know, this is the first genetic report of germline EPHB4 loss-of-functional mutation related CM-AVM 2 in Asians, extending our understanding of CM-AVM.
The Neuroprotective Effects of Xenon on Neonatal Rats with White Matter Damage by Regulating Expression of microRNA-210 and HIF-1αThe Neuroprotective Effects of Xenon on Neonatal Rats with White Matter Damage by Regulating Expression of microRNA-210 and HIF-1α
Authors: Yin Xiangyun , Zhao Jixiu , Jiang Jian , Xi Hongmin , Li Xianghong , Zhang Lulu , Jiang Hong 
Published: August 2020

Abstract
Background:Premature infant is a significant health care burden. White matter damage (WMD) is a leading cause of acute mortality and chronic morbidity in preterm. Xenon (Xe) intervention was given to the 3-day-old neonatal rats with brain white matter injury. By detecting the changes in the expression level of microRNA210 and hypoxia inducible factor 1α (HIF-1α) in brain tissue before and after xenon intervention, we can research the molecular basis and the mechanism of neuroprotective on effect of xenon on brain white matter damage in neonatal rats.Methods:Three-day-old SD rats were randomly divided into sham group(Group A, n=24), lipopolysaccharide(LPS)+hypoxia-ischemia(HI) group (Group B, n=24) and LPS+HI+Xe group ( n=72). The onset of Xe inhalation started at 0,2 and 5 hours in subgroups C,D,and E respectively.We investigated the neurobehavioral deficits by performing TUNEL and hematoxylin and eosin (HE) staining and examining the expression of miR-210and HIF-1α in brain tissues via RT-PCR and western blot. Results: Xe treatment improved the histological alterations and decreased the number of apoptotic cells in group C pups.Compared to group A,Detection of miR-210 level by RT-PCR. the expression level of miR-210 in neonatal rats' periventricular tissue increased significantly at all time points in group B (p<0.05).While the expression level of miR-210 in brain tissues of group B was significantly lower at 48h and 72h than that of group C(p<0.05).Similarly,Detection of HIF-1α protein by Western blot. The level of HIF-1α protein in group B brain tissues was significantly higher than that of group A at each time point (p<0.05), Xe treatment resulted in a marked increase in HIF-1α in C,D, and E subgroups (P < 0.05, compared to group B).Conclusions: These results demonstrate that the expression of HIF-1α and miR-210 increased in periventricular tissues and Xe could relieve the white matter damage by up-regulating the expression of HIF-1α and its target gene miR-210.The Xe therapeutic time window was within 5 hours after intervention, the sooner the better.
Flaxseed Polysaccharide Altering Colonic Gene Expression of Lipid Metabolism and Energy Metabolism in Obese Rat
Authors: Lin Xiaohong , Qi Jiamei , Zhang Guangwen , Peng Xichun 
Published: August 2020

Abstract
BackgroundObesity is one of the most serious public health challenges. Recently, we found that flaxseed polysaccharide (FP) had an anti-obesity effect through promoting lipid metabolism, inducing satiety and regulating gut microbiota, but how FP promote lipid metabolism through altering the colonic epithelial cells remains to be elucidated. In this study, a transcriptome study was performed to investigate the effect of FP altering the gene expression of colonic epithelial cells in an obese rat model. ResultsThe transcriptome analysis showed that 3,785 genes were differentially expressed after FP intervention in colonic epithelial cells, including 374 down-regulated and 3,411 up-regulated genes. Through KEGG analysis, we found out three classical pathways related to lipid metabolism and energy metabolism, including PPAR signaling pathway, nitrogen metabolism and oxidative phosphorylation (OXPHOS). Moreover, qRT-PCR results showed consistent expression trends of differential genes with transcriptome analysis. ConclusionsThe anti-obesity effect of FP may be achieved by regulating the expression of lipid metabolism- and energy metabolism-related proteins acting on the PPAR (peroxisome proliferator-activated receptor) signaling pathway, nitrogen metabolism and OXPHOS pathway in vivo.
Endoscopic lung volume reduction coils for patients with severe emphysema – a single-center retrospective analysis
Authors: Mang Sebastian , Hus Niklas , Schäfers Hans-Joachim , Wehrfritz Holger , Massmann Alexander , Lensch Christian , Langer Frank , Seiler Frederik , Bals Robert , Lepper Philipp M. 
Published: August 2020

Abstract
BackgroundPatients with chronic obstructive pulmonary disease (COPD) and lung emphysema may benefit from surgical or endoscopic lung volume reduction (ELVR). Previously reported outcomes of nitinol-coil-based endoscopic lung volume reduction techniques have been ambiguous.Objectives The analysis was done to analyze outcomes of ELVR with nitinol-coils in patients with severe pulmonary emphysema.MethodsFrom September 2013 to November 2014, our center performed a total of 41 coil implantations on 29 patients with severe emphysema. Coils were bronchoscopically placed during general anesthesia. 12 out of 29 patients received contralateral treatments 4-6 weeks later to avoid bilateral pneumothorax. Lung function and 6-minute walking distance were assessed one week prior, one week after as well as 6 to 12 months after the procedure. Patients were followed up to 48 months after ELVR and overall mortality was compared to a historic cohort.ResultsWhile coil-based ELVR led to significant short-term improvement of vital capacity (VC, + 0.14 l ± 0.39 l, p = 0.032) and hyperinflation (ΔRV / TLC -2.32% ± 6.24%, p = 0.022), no significant changes were observed in 6-minute walking distance (6-MWD) or forced expiratory volume in one second (FEV1). Benefits were short-lived, with only 15.4% and 14.3% of patients showing sustained improvements in FEV1 or residual volume (RV) after 6 months. Adverse events included hemoptysis (40 %) and pneumothorax (3.4 %), major complications occurred in 6.9% of cases. Overall survival without lung transplant was 63.8% after 48 months following ELVR, differing insignificantly from what BODE indices of patients would have predicted as median 4-year survival (57%) at the time of ELVR treatment.ConclusionEndoscopic lung volume reduction coils can achieve small and short-lived benefits in lung function at the cost of major complications in a highly morbid cohort. Treatment failed to improve 4-year overall survival. ELVR coils are not worthwhile the risk for most patients with severe emphysema.
Uso de residuos de café como biosorbente para la remoción de metales pesados en aguas residuales
Authors: Carvajal Florez Elizabeth , Marulanda Luisa Fernanda 
Published: August 2020

El presente artículo presenta una revisión de los diferentes residuos del beneficio y consumo de café, usados como material adsorbente en la biosorción de metales pesados de soluciones acuosas. Se esboza en primera instancia particularidades de la biosorción, como los mecanismos de captura de los contaminantes, tipos de materiales adsorbentes, entre ellos los provenientes del café, como las variables que controlan el proceso. En una segunda instancia se plasman investigaciones en relación a la biosorción, en las que se desarrollaron cinéticas químicas para evaluar velocidades de remoción de los metales pesados, e isotermas para determinar tasas o capacidades de adsorción con los residuos de café modificados térmica o químicamente. Se puede señalar que muchos autores han encontrado ventajas competitivas frente al uso de residuos café como la pulpa, borra, mucílago, entre otros, en comparación con adsorbentes convencionales, debido a su propiedades fisicoquímicas los convierten en unos excelentes intercambiadores iónicos , son de alta abundancia debido a la vocación agrícola del país y al alto consumo del café a nivel nacional e internacional, además de su bajo costo y facilidad de manejo y tratamiento, concluyéndose entonces que dichos materiales presentan un futuro promisorio en el tratamiento de efluentes líquidos.
Modelo de adecuabilidad para representar zonas de favorabilidad para la explotación de un depósito geotérmico
Authors: Zuluaga Valencia Carlos Nicolás , Londoño Ciro Libardo Antonio 
Published: August 2020

En este artículo se presenta un modelo de adecuabilidad para representar zonas de favorabilidad geotérmica a partir de datos de las variables Gravedad, Anomalía de Bouguer y Campo Magnético Terrestre, que permita delimitar y optimizar los procesos de exploración geocientífica para la realización de perforaciones exploratorias profundas. Los datos se han tomado de estudios de exploración geotérmica adelantada en el Complejo Volcánico del Nevado del Ruiz (CVNR) durante los años 1980, 1983 y 2015, los cuales se depuraron mediante la comparación entre las cotas obtenidas en campo y un MDE más reciente, sin tener en cuenta los valores de gravedad medidos. Se evaluaron diferentes modelos con validación cruzada para obtener el mejor modelo para representar las superficies de las tres variables de trabajo y mediante AHP se procede a hacer un análisis de escenarios que finalmente permite obtener el mapa de adecuabilidad con las zonas de mejor favorabilidad geotérmica.
Ash depth filter sanitation eliminates all bacteria and makes source-separated urine waste sterile
Authors: Witty Michael , Copley Sarah , Dingra Nin N. , Al-Bahou Raja , Na Ayudhya Theppawut Israsena 
Published: August 2020

Abstract
Remote houses cannot use sewerage systems and so they must make their own arrangements for waste disposal. A solution is the use of ash depth filters which simultaneously trap nitrogen and phosphorus from human waste streams and all bacteria during long periods (750 ml per day for more than 6 weeks) of operation by filtration under gravity. Bacteria entering the filtration system, those trapped by the filter and the living material which eventually emerges if the system is operated till it eventually fails, are characterized. Reduction of bacterial numbers is achieved by two mechanisms: physical filtration and chemical sanitation.
Serum Uric Acid and Progression of Autosomal Dominant Polycystic Kidney Disease: Results from the HALT PKD Trials
Authors: Brosnahan Godela M. , You Zhiying , Wang Wei , Gitomer Berenice Y. , Chonchol Michel 
Published: August 2020

Background:
Epidemiological studies have suggested that elevated serum uric acid may
contribute to the progression of chronic kidney disease. However, no large prospective study has
examined whether hyperuricemia is an independent risk factor for the progression of autosomal
dominant polycystic kidney disease (ADPKD).

Methods:
We measured uric acid in stored serum samples from the 2-year study visit of 671 participants
from the HALT PKD multicenter trials. Participants were categorized according to uric acid
tertiles. For Study A (participants aged 15-49 years with preserved kidney function, n=350), we
used linear mixed effects models to examine the association between uric acid and repeated measures
of height-adjusted total kidney volume (htTKV), the primary outcome for Study A. For
Study B (participants aged 18-64 with decreased kidney function, n=321), we used Cox proportional
hazards models to assess the hazard for the combined endpoint of 50% loss in estimated glomerular
filtration rate (eGFR), end-stage kidney disease (ESKD), or death, the primary outcome for
Study B. To assess the association of uric acid with the slope of eGFR decline (secondary outcome
of HALT A and B), we used linear mixed effects models for the combined population of Study A
and B.

Results:
In the unadjusted model, the annual change in htTKV was 2.7% higher in the highest uric
acid tertile compared to the lowest (p<0.001), but this difference became insignificant after adjustment
for gender. Men had faster TKV growth than women (p<0.001). There was no difference in
eGFR decline between the 3 uric acid tertiles. Hazard ratios for the clinical endpoint were 2.9 (95%
confidence interval, 1.9-4.4) and 1.8 (1.1-2.8) respectively in the high and medium uric acid groups
in unadjusted and partially adjusted models (p<0.001), but the significance was lost after adjustment
for baseline eGFR. Results were similar when uric acid was examined as a continuous variable.

Conclusion:
Elevated serum uric acid is not an independent risk factor for disease progression in ADPKD.
New Developments in Anti-Angiogenic Therapy of Cancer, Review and Update
Authors: Ghasemali Samaneh , Farajnia Safar , Barzegar Abolfazl , Rahmati-Yamchi Mohammad , Baghban Roghayyeh , Rahbarnia Leila , Nodeh Hamid R.Y. 
Published: August 2020

Background:
Angiogenesis is one of the critical physiological processes, by which the new blood
vessels are generated from the pre-existing vessels in the early stage of vasculogenesis. While normal angiogenesis
is critical for development and tissue growth, pathologic angiogenesis is important for the growth and
spread of cancers by supplying nutrients and oxygen as well as providing a conduit for distant metastasis. In the
last two decades, angiogenesis has been the area of extensive researches, indicating antiangiogenic target therapy
as an effective strategy for cancer therapy. At present, this field has become a major avenue for research and
development of novel therapeutics.

Objective:
This review is dedicated to an updated review of the most prominent antiangiogenic agents, emphasizing
the novel advancements and their applications, in particular, in the fields of antibodies, peptides, vaccines,
endogenous inhibitors, Nanoparticles (NPs), antiangiogenic oligonucleotides and small molecules. Also,
the potential role of 3D microfluidic models as an affordable and time-saving tool for angiogenesis investigations
are discussed.

Methods:
Firstly, we collected and summarized new developments that have occurred in all review and research
articles in databases. Then, we used important keywords related to antiangiogenic target therapy and their applications
for retrieval of most relevant data.

Results:
This review is based on recent research and review articles and intended to cover all newly discovered
agents inhibiting tumor angiogenesis and in particular, VEGF.

Conclusion:
New research studies have shown that anti-angiogenesis agents especially, in the form of combination
therapy are effective in various cancers treatment.
Analysis of the Effect of Separate Collection on the Composition of Mixed Municipal Solid Waste in Italy
Authors: Calabrò Paolo S. , Pangallo Domenica 
Published: August 2020

Separate collection of municipal solid waste (MSW) is mandatory in Italy, and an increasingly higher standard of efficiency is applied; in fact, the target value set by regulation is 65%.
In the last 20 years, separate collection efficiency increased from 9.4% with 80% national MSW landfilled, and only one region was over 25% separate collection to 58.1% with 22% national MSW landfilled and 12 of 20 regions over 55% separate collection. However, significant differences are present in the three Italian macro regions (North, Center and South).
This paper analyzes the composition of waste carried in most Italian regions to evaluate the effect of separate collection on the composition of mixed municipal solid waste (unsorted). Moreover, a regression analysis on the same data allows to assess this latter as a function of separate collection efficiency.
Elke Diel und Jens Tuider (Hrsg.): Haben Tiere Rechte?
Authors: Müller Nico 
Published: August 2020

Rezension von Elke Diel und Jens Tuider (Hrsg.): Haben Tiere Rechte? Aspekte und Dimensionen der Mensch-Tier-Beziehung. Bonn, Bundeszentrale für Politische Bildung, 2019.
Technological Capabilities to Assess Digital Excellence in Hospitals in High Performing Health Care Systems: International eDelphi Exercise
Authors: Krasuska Marta , Williams Robin , Sheikh Aziz , Franklin Bryony Dean , Heeney Catherine , Lane Wendy , Mozaffar Hajar , Mason Kathy , Eason Sally , Hinder Susan , Dunscombe Rachel , Potts Henry W W , Cresswell Kathrin 
Published: August 2020

BackgroundHospitals worldwide are developing ambitious digital transformation programs as part of broader efforts to create digitally advanced health care systems. However, there is as yet no consensus on how best to characterize and assess digital excellence in hospitals.ObjectiveOur aim was to develop an international agreement on a defined set of technological capabilities to assess digital excellence in hospitals.MethodsWe conducted a two-stage international modified electronic Delphi (eDelphi) consensus-building exercise, which included a qualitative analysis of free-text responses. In total, 31 international health informatics experts participated, representing clinical, academic, public, and vendor organizations.ResultsWe identified 35 technological capabilities that indicate digital excellence in hospitals. These are divided into two categories: (a) capabilities within a hospital (n=20) and (b) capabilities enabling communication with other parts of the health and social care system, and with patients and carers (n=15). The analysis of free-text responses pointed to the importance of nontechnological aspects of digitally enabled change, including social and organizational factors. Examples included an institutional culture characterized by a willingness to transform established ways of working and openness to risk-taking. The availability of a range of skills within digitization teams, including technological, project management and business expertise, and availability of resources to support hospital staff, were also highlighted.ConclusionsWe have identified a set of criteria for assessing digital excellence in hospitals. Our findings highlight the need to broaden the focus from technical functionalities to wider digital transformation capabilities.
Behavior Change Text Messages for Home Exercise Adherence in Knee Osteoarthritis: Randomized Trial
Authors: Bennell Kim , Nelligan Rachel K , Schwartz Sarah , Kasza Jessica , Kimp Alexander , Crofts Samuel JC , Hinman Rana S 
Published: August 2020

Background
Exercise is a core recommended treatment for knee osteoarthritis (OA), yet adherence declines, particularly following cessation of clinician supervision.

Objective
This study aims to evaluate whether a 24-week SMS intervention improves adherence to unsupervised home exercise in people with knee OA and obesity compared with no SMS.

Methods
A two-group superiority randomized controlled trial was performed in a community setting. Participants were people aged 50 years with knee OA and BMI ≥30 kg/m2 who had undertaken a 12-week physiotherapist-supervised exercise program as part of a preceding clinical trial. Both groups were asked to continue their home exercise program unsupervised three times per week for 24 weeks and were randomly allocated to a behavior change theory–informed, automated, semi-interactive SMS intervention addressing exercise barriers and facilitators or to control (no SMS). Primary outcomes were self-reported home exercise adherence at 24 weeks measured by the Exercise Adherence Rating Scale (EARS) Section B (0-24, higher number indicating greater adherence) and the number of days exercised in the past week (0-3). Secondary outcomes included self-rated adherence (numeric rating scale), knee pain, physical function, quality of life, global change, physical activity, self-efficacy, pain catastrophizing, and kinesiophobia.

Results
A total of 110 participants (56 SMS group and 54 no SMS) were enrolled and 99 (90.0%) completed both primary outcomes (48/56, 86% SMS group and 51/54, 94% no SMS). At 24 weeks, the SMS group reported higher EARS scores (mean 16.5, SD 6.5 vs mean 13.3, SD 7.0; mean difference 3.1, 95% CI 0.8-5.5; P=.01) and more days exercised in the past week (mean 1.8, SD 1.2 vs mean 1.3, SD 1.2; mean difference 0.6, 95% CI 0.2-1.0; P=.01) than the control group. There was no evidence of between-group differences in secondary outcomes.

Conclusions
An SMS program increased self-reported adherence to unsupervised home exercise in people with knee OA and obesity, although this did not translate into improved clinical outcomes.

Trial Registration
Australian New Zealand Clinical Trials Registry 12617001243303; https://tinyurl.com/y2ud7on5

International Registered Report Identifier (IRRID)
RR2-10.1186/s12891-019-2801-z