bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ion Reservoir Enabled by Hierarchical Bimetallic Sulfides Nanocages Toward Highly Effective Sodium Storage
Authors: Yuan Jin , Qu Baihua , Zhang Qingfei , He Wei , Xie Qingshui , Peng Dong‐Liang 
Published: June 2020

AbstractDesigning and constructing bimetallic hierarchical structures is vital for the conversion‐alloy reaction anode of sodium‐ion batteries (SIBs). Particularly, the rationally designed hetero‐interface engineering can offer fast diffusion kinetics in the interface, leading to the improved high‐power surface pseudocapacitance and cycling stability for SIBs. Herein, the hierarchical zinc–tin sulfide nanocages (ZnS‐NC/SnS2) are constructed through hydrothermal and sulfuration reactions. The unconventional hierarchical design with internal void space greatly optimizes the structure stability, and bimetallic sulfide brings a bimetallic composite interface and N heteroatom doping, which are devoted to high electrochemical activity and improved interfacial charge transfer rate for Na+ storage. Remarkably, the ZnS‐NC/SnS2 composite anode exhibits a delightful reversible capacity of 595 mAh g−1 after 100 cycles at 0.2 A g−1, and long cycling capability for 500 cycles with a low capacity loss of 0.08% per cycle at 1 A g−1. This study opens up a new route for rationally constructing hierarchical heterogeneous interfaces and sheds new light on efficient anode material for SIBs.
Bioelectronic Skin Based on Nociceptive Ion Channel for Human‐Like Perception of Cold Pains
Authors: Shin Narae , Lee Seung Hwan , Cho Youngtak , Park Tai Hyun , Hong Seunghun 
Published: June 2020

AbstractA bioelectronic skin device based on nociceptive ion channels in nanovesicles is developed for the detection of chemical cold‐pain stimuli and cold environments just like human somesthetic sensory systems. The human transient receptor potential ankyrin 1 (hTRPA1) is involved in transmission and modulation of cold‐pain sensations. In the bioelectronic skin, the nanovesicles containing the hTRPA1 nociceptive ion channel protein reacts to cold‐pain stimuli, and it is electrically monitored through carbon nanotube transistor devices based on floating electrodes. The bioelectronic skin devices sensitively detect chemical cold‐pain stimuli like cinnamaldehyde at 10 fm, and selectively discriminate cinnamaldehyde among other chemical stimuli. Further, the bioelectronic skin is used to evaluate the effect of cold environments on the response of the hTRPA1, finding that the nociceptive ion channel responds more sensitively to cinnamaldehyde at lower temperatures than at higher temperatures. The bioelectronic skin device could be useful for a basic study on somesthetic systems such as cold‐pain sensation, and should be used for versatile applications such as screening of foods and drugs.
Toward ontology‐based risk management framework for software projects: An empirical study
Authors: Abioye Temitope Elizabeth , Arogundade Oluwasefunmi Tale , Misra Sanjay , Akinwale Adio T. , Adeniran Olusola John 
Published: June 2020

AbstractSoftware risk management is a proactive decision‐making practice with processes, methods, and tools for managing risks in a software project. Many existing techniques for software project risk management are textual documentation with varying perspectives that are nonreusable and cannot be shared. In this paper, a life‐cycle approach to ontology‐based risk management framework for software projects is presented. A dataset from literature, domain experts, and practitioners is used. The identified risks are refined by 19 software experts; risks are conceptualized, modeled, and developed using Protégé. The risks are qualitatively analyzed and prioritized, and aversion methods are provided. The framework is adopted in real‐life software projects. Precision recall and F‐measure metrics are used to validate the performance of the extraction tool while performance and perception evaluation are carried out using the performance appraisal form and technology acceptance model, respectively. Mean scores from performance and perception evaluation are compared with evaluation concept scale. Results showed that cost is reduced, high‐quality projects are delivered on time, and software developers found this framework a potent tool needed for their day‐to‐day activities in software development.
Synthesis of several 2‐carbaldehyde derivatives of quinoline and 1,4‐dihydroquinoline
Authors: Chinh Pham The , Tham Pham Thi , Van Tuyen Nguyen , Quynh Duong Huong , Van Dinh Thuy , Bang Duong Nghia , Kien Vu Tuan , Giang Bui Duong , Thuy Nguyen Thi , Nhan Bui Thanh , Giang Luu Truong 
Published: June 2020

AbstractQuinolines represent a versatile class of compounds known for their antimalarial potential. The quinoline derivatives are the class of truly ubiquitous structures involved in the regulation of a wide variety of biological processes. In this paper, several quinoline‐2‐carbaldehyde and 1,4‐dihydroquinoline‐2‐carbaldehyde derivatives were synthesized via Riley reaction. These valuable organic compounds are unique precursors for the synthesis of new plinabulin and new heterocyclic compounds containing ring system of quinolines.
Simultaneous effect of pH, deposition time, deposition potential, and step potential on the stripping peak current of copper on platinum nanoflowers modified glassy carbon electrode (PtNFs/GCE) using response surface methodology
Authors: Lieu Nguyen Thi , Trung Pham Quoc , Trang Le Tran Thu , Giang Le Truong 
Published: June 2020

AbstractIn the present study, the glassy carbon electrode (GCE) modified with platinum nanoflowers (PtNFs/GCE) has been developed for copper determination. Differential pulse anodic stripping voltammetry (DPASV) was used to investigate the performance of the modified electrode. The effects of pH, deposition potential, deposition time, and step potential were investigated on the stripping peak current response of copper based on response surface methodology. The results indicated that pH of 5.07, deposition potential (‐0.605 V), deposition time (150.4 s), and step potential (6 mV) results in the maximum current density. Under the optimized conditions, a linear regression was obtained in the range of 0.75‐80 μg.L‐1 and detection limit also was found to be 0.312 μg.L‐1 by DPASV on the PtNFs/GCE surface. The fabricated electrode (PtNFs/GCE) showed good reproducibility and repeatability as well as high recovery. The practical application of the PtNFs/GCE was demonstrated by measuring the concentration of copper in real water samples.
Effects of glycerol and NCO/OH on rigid polyurethane foam based on bio‐polyol of rubber seed oil using water as blowing agent
Authors: Thuy Nuyen Thi , Vuong Trinh Quoc , Duc Vu Minh 
Published: June 2020

AbstractThe work used bio‐polyol from rubber seed oil for rigid polyurethane synthesis. The water was used as the only blowing agent. FTIR spectrum demonstrated the formation of polyurethanes from bio‐polyol, glycerol, isocyanate and water. The effects of water, glycerol content and NCO/OH molar ratio on properties of foam were investigated through compression strength, density, average porous radius, size and distribution of cells. The suitable recipe for materials was chosen and the cream time, the rise time and the tack free time were also determined. The rigid polyurethane foam was synthesized at water and glycerol content of 4 and 3 wt.% of polyol, molar NCO/OH ratio of 0.8 had the compressive strength of 125.11 KPa, density of 62.75 kg/m3 and average porous radius of 237.52 μm.
Pyridylmethylamines a modular and underrated family of ligands in both metal‐ and organo‐catalysis
Authors: Large Benjamin , Plais Romain , Gaucher Anne , Prim Damien 
Published: June 2020

AbstractThis account outlines our recent investigations towards the synthesis, complexation and properties of pyridylmethylamines (pma) ligands. A careful study combining solid state data, advanced NMR techniques and DFT calculations allowed to study the topology of Pd(II) and Zn(II) complexes and to decipher their privileged structural arrangements. Our approach also permitted to understand the behaviour of catalytic systems in both metal‐ and organo‐catalysis. The efficiency of pma‐catalytic systems towards Suzuki couplings, C‐H alkylation, C‐H arylation, Michael addition and Henry reaction is illustrated through selected examples.
Well-Posedness for a System of Quadratic Derivative Nonlinear Schrödinger Equations with Radial Initial Data
Authors: Hirayama Hiroyuki , Kinoshita Shinya , Okamoto Mamoru 
Published: June 2020

AbstractIn the present paper, we consider the Cauchy problem of the system of quadratic derivative nonlinear Schrödinger equations. This system was introduced by Colin and Colin (Differ Integral Equ 17:297–330, 2004). The first and second authors obtained some well-posedness results in the Sobolev space $$H^{s}({\mathbb R}^d)$$

H
s

(

R

d

)

. We improve these results for conditional radial initial data by rewriting the system radial form.
Postinfektiöse reaktive Arthritis nach Chlamydieninfektion im Leistungssport
Authors: Klingebiel Sebastian , Rieger Horst , Gosheger Georg , Theil Jan Christoph , Rickert Carolin , Schneider Kristian Nikolaus 
Published: June 2020

Zusammenfassung
Hintergrund
Die reaktive Arthritis infolge einer Chlamydieninfektion ist eine seltene, aber wichtige Differenzialdiagnose der atraumatischen Gelenkschwellung. Eine verzögerte Diagnosestellung führt nicht selten zu langen Ausfallzeiten der sportlichen Aktivität, die gerade beim Leistungssportler weitreichende Konsequenzen haben kann.

Ziel der Arbeit
Darstellung des klinischen Managements der postinfektiösen reaktiven Arthritis zur schnellen Diagnosestellung und zielgerichteten Behandlung bei symptomatischem Krankheitsverlauf.

Material und Methoden
Literaturrecherche zu den Themen „Chlamydien“, „reaktive Arthritis“, „postinfektiöse Arthritis“ und „sexually acquired reactive arthritis“ einschließlich Darstellung von zwei klinischen Fällen der postinfektiösen reaktiven Arthritis nach Chlamydieninfektion aus dem Leistungssport.

Ergebnisse und Fazit
Die reaktive Arthritis nach Chlamydieninfektion bei Leistungssportlern ist eine seltene Entität. Sie kann jedoch durchaus mit weitreichenden individuellen Folgen, insbesondere hinsichtlich möglicher Ausfallzeiten, im Sport einhergehen. Auch langfristige Folgen, wie chronische Gelenkschäden bei unterhaltener Synovialitis, müssen bedacht werden. Zur Diagnosestellung ist eine gezielte Anamneseerhebung und der direkte Erregernachweis im Gelenkpunktat durch die Polymerasekettenreaktion essenziell. Dies erlaubt eine sichere Diagnosestellung mit verzögerungsfreier Therapieeinleitung. Jedoch sind auch bei frühzeitigem Therapiebeginn protrahierte Krankheitsverläufe nicht ausgeschlossen.
Reinterpreting shock wave structure predictions using the Navier–Stokes equations
Authors: Reddy M. H. L. , Dadzie S. K. 
Published: June 2020

AbstractClassical Navier–Stokes equations fail to predict shock wave profiles accurately. In this paper, the Navier–Stokes system is fully transformed using a velocity variable transformation. The transformed equations termed the recast Navier–Stokes equations display physics not initially included in the classical form of the equations. We then analyze the stationary shock structure problem in a monatomic gas by solving both the classical and the recast Navier–Stokes equations numerically using a finite difference global solution (FDGS) scheme. The numerical results are presented for different upstream Mach numbers ranging from supersonic to hypersonic flows. We found that the recast Navier–Stokes equations show better agreement with the experimentally measured density and reciprocal shock thickness profiles.
The IRI-DICE hypothesis: ionizing radiation-induced DSBs may have a functional role for non-deterministic responses at low doses
Authors: Langen Britta , Helou Khalil , Forssell-Aronsson Eva 
Published: June 2020

AbstractLow-dose ionizing radiation (IR) responses remain an unresolved issue in radiation biology and risk assessment. Accurate knowledge of low-dose responses is important for estimation of normal tissue risk in cancer radiotherapy or health risks from occupational or hazard exposure. Cellular responses to low-dose IR appear diverse and stochastic in nature and to date no model has been proposed to explain the underlying mechanisms. Here, we propose a hypothesis on IR-induced double-strand break (DSB)-induced cis effects (IRI-DICE) and introduce DNA sequence functionality as a submicron-scale target site with functional outcome on gene expression: DSB induction in a certain genetic target site such as promotor, regulatory element, or gene core would lead to changes in transcript expression, which may range from suppression to overexpression depending on which functional element was damaged. The DNA damage recognition and repair machinery depicts threshold behavior requiring a certain number of DSBs for induction. Stochastically distributed persistent disruption of gene expression may explain—in part—the diverse nature of low-dose responses until the repair machinery is initiated at increased absorbed dose. Radiation quality and complexity of DSB lesions are also discussed. Currently, there are no technologies available to irradiate specific genetic sites to test the IRI-DICE hypothesis directly. However, supportive evidence may be achieved by developing a computational model that combines radiation transport codes with a genomic DNA model that includes sequence functionality and transcription to simulate expression changes in an irradiated cell population. To the best of our knowledge, IRI-DICE is the first hypothesis that includes sequence functionality of different genetic elements in the radiation response and provides a model for the diversity of radiation responses in the (very) low dose regimen.
Long-term efficacy and safety of alemtuzumab in patients with RRMS: 12-year follow-up of CAMMS223
Authors: Steingo Brian , Al Malik Yaser , Bass Ann D. , Berkovich Regina , Carraro Matthew , Fernández Óscar , Ionete Carolina , Massacesi Luca , Meuth Sven G. , Mitsikostas Dimos D. , Pardo Gabriel , Simm Renata Faria , Traboulsee Anthony , Choudhry Zia , Daizadeh Nadia , Compston D. Alastair S. ,   the CAMMS223, CAMMS03409, and TOPAZ Investigators
Published: June 2020

AbstractBackgroundIn the phase 2 CAMMS223 trial (NCT00050778), alemtuzumab significantly improved clinical and MRI outcomes versus subcutaneous interferon beta-1a over 3 years in treatment-naive patients with relapsing–remitting MS. Here, we assess efficacy and safety of alemtuzumab over 12 years in CAMMS223 patients who enrolled in the CAMMS03409 extension (NCT00930553), with available follow-up through the subsequent TOPAZ extension (NCT02255656).MethodsIn CAMMS223, patients received 2 alemtuzumab courses (12 mg/day; baseline: 5 days; 12 months later: 3 days); 22% received a third course. In the open-label, nonrandomized extensions, patients could receive as-needed additional alemtuzumab or other disease-modifying therapies.ResultsOf 108 alemtuzumab-treated patients in CAMMS223, 60 entered the CAMMS03409 extension; 33% received a total of 2 alemtuzumab courses, and 73% received no more than 3 courses through Year 12. Over 12 years, annualized relapse rate was 0.09, 71% of patients had stable or improved Expanded Disability Status Scale scores, and 69% were free of 6-month confirmed disability worsening. In Year 12, 73% of patients were free of MRI disease activity. Cumulatively throughout the extensions (Years 7–12), 34% of patients had no evidence of disease activity. Adverse event (AE) incidence declined through Year 12. Infusion-associated reactions peaked at first course and declined thereafter. Cumulative thyroid AE incidence was 50%; one immune thrombocytopenia event occurred, and there were no autoimmune nephropathy cases.ConclusionsAlemtuzumab efficacy was maintained over 12 years in CAMMS223 patients, with 73% receiving no more than three courses. The safety profile in this cohort was consistent with other alemtuzumab clinical trials.
Systematic literature review of burden of illness in chronic inflammatory demyelinating polyneuropathy (CIDP)
Authors: Querol Luis , Crabtree M. , Herepath M. , Priedane E. , Viejo Viejo I. , Agush S. , Sommerer P. 
Published: June 2020

Abstract
Background
Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare neurological disorder characterised by muscle weakness and impaired sensory function. The present study provides a comprehensive literature review of the burden of illness of CIDP.

Methods
Systematic literature search of PubMed, Embase, and key conferences in May 2019. Search terms identified studies on the epidemiology, humanistic burden, current treatment, and economic burden of CIDP published since 2009 in English.

Results
Forty-five full texts and nineteen conference proceedings were identified on the epidemiology (n = 9), humanistic burden (n = 7), current treatment (n = 40), and economic burden (n = 8) of CIDP. Epidemiological studies showed incidence and prevalence of 0.2–1.6 and 0.8–8.9 per 100,000, respectively, depending on geography and diagnostic criteria. Humanistic burden studies revealed that patients experienced physical and psychosocial burden, including impaired physical function, pain and depression. Publications on current treatments reported on six main types of therapy: intravenous immunoglobulins, subcutaneous immunoglobulins, corticosteroids, plasma exchange, immunosuppressants, and immunomodulators. Treatments may be burdensome, due to adverse events and reduced independence caused by treatment administration setting. In Germany, UK, France, and the US, CIDP economic burden was driven by direct costs of treatment and hospitalisation. CIDP was associated with indirect costs driven by impaired productivity.

Conclusions
This first systematic review of CIDP burden of illness demonstrates the high physical and psychosocial burden of this rare disease. Future research is required to fully characterise the burden of CIDP, and to understand how appropriate treatment can mitigate burden for patients and healthcare systems.
Olfactory testing does not predict β-amyloid, MRI measures of neurodegeneration or vascular pathology in the British 1946 birth cohort
Authors: Buchanan Sarah M. , Parker Thomas D. , Lane Christopher A. , Keshavan Ashvini , Keuss Sarah E. , Lu Kirsty , James Sarah-Naomi , Murray-Smith Heidi , Wong Andrew , Nicholas Jennifer , Cash David M. , Malone Ian B. , Coath William , Thomas David L. , Sudre Carole , Fox Nick C. , Richards Marcus , Schott Jonathan M. 
Published: June 2020

Abstract
Objective
To explore the value of olfactory identification deficits as a predictor of cerebral β-amyloid status and other markers of brain health in cognitively normal adults aged ~ 70 years.

Methods
Cross-sectional observational cohort study. 389 largely healthy and cognitively normal older adults were recruited from the MRC National Survey of Health and Development (1946 British Birth cohort) and investigated for olfactory identification deficits, as measured by the University of Pennsylvania Smell Identification Test. Outcome measures were imaging markers of brain health derived from 3 T MRI scanning (cortical thickness, entorhinal cortex thickness, white matter hyperintensity volumes); 18F florbetapir amyloid-PET scanning; and cognitive testing results. Participants were assessed at a single centre between March 2015 and January 2018.

Results
Mean (± SD) age was 70.6 (± 0.7) years, 50.8% were female. 64.5% had hyposmia and 2.6% anosmia. Olfaction showed no association with β-amyloid status, hippocampal volume, entorhinal cortex thickness, AD signature cortical thickness, white matter hyperintensity volume, or cognition.

Conclusion and relevance
In the early 70s, olfactory function is not a reliable predictor of a range of imaging and cognitive measures of preclinical AD. Olfactory identification deficits are not likely to be a useful means of identifying asymptomatic amyloidosis. Further studies are required to assess if change in olfaction may be a proximity marker for the development of cognitive impairment.
De novo CACAN1D Ca2+ channelopathies: clinical phenotypes and molecular mechanism
Authors: Ortner Nadine J. , Kaserer Teresa , Copeland J. Nathan , Striessnig Jörg 
Published: June 2020

AbstractThe identification of rare disease-causing variants in humans by large-scale next-generation sequencing (NGS) studies has also provided us with new insights into the pathophysiological role of de novo missense variants in the CACNA1D gene that encodes the pore-forming α1-subunit of voltage-gated Cav1.3 L-type Ca2+ channels. These CACNA1D variants have been identified somatically in aldosterone-producing adenomas as well as germline in patients with neurodevelopmental and in some cases endocrine symptoms. In vitro studies in heterologous expression systems have revealed typical gating changes that indicate enhanced Ca2+ influx through Cav1.3 channels as the underlying disease-causing mechanism. Here we summarize the clinical findings of 12 well-characterized individuals with a total of 9 high-risk pathogenic CACNA1D variants. Moreover, we propose how information from somatic mutations in aldosterone-producing adenomas could be used to predict the potential pathogenicity of novel germline variants. Since these pathogenic de novo variants can cause a channel-gain-of function, we also discuss the use of L-type Ca2+ channel blockers as a potential therapeutic option.
Identification of novel genetic variants associated with short stature in a Baka Pygmies population
Authors: Zoccolillo Matteo , Moia Claudia , Comincini Sergio , Cittaro Davide , Lazarevic Dejan , Pisani Karen A. , Wit Jan M. , Bozzola Mauro 
Published: June 2020

AbstractHuman growth is a complex trait determined by genetic factors in combination with external stimuli, including environment, nutrition and hormonal status. In the past, several genome-wide association studies (GWAS) have collectively identified hundreds of genetic variants having a putative effect on determining adult height in different worldwide populations. Theoretically, a valuable approach to better understand the mechanisms of complex traits as adult height is to study a population exhibiting extreme stature phenotypes, such as African Baka Pygmies. After phenotypic characterization, we sequenced the whole exomes of a cohort of Baka Pygmies and their non-Pygmies Bantu neighbors to highlight genetic variants associated with the reduced stature. Whole exome data analysis revealed 29 single nucleotide polymorphisms (SNPs) significantly associated with the reduced height in the Baka group. Among these variants, we focused on SNP rs7629425, located in the 5′-UTR of the Hyaluronidase-2 (HYAL2) gene. The frequency of the alternative allele was significantly increased compared to African and non-African populations. In vitro luciferase assay showed significant differences in transcription modulation by rs7629425 C/T alleles. In conclusion, our results suggested that the HYAL2 gene variants may play a role in the etiology of short stature in Baka Pygmies population.