bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proteomic Evaluation of the Natural History of the Acute Radiation Syndrome of the Gastrointestinal Tract in a Non-human Primate Model of Partial-body Irradiation with Minimal Bone Marrow Sparing Includes Dysregulation of the Retinoid Pathway
Authors: Huang Weiliang , Yu Jianshi , Liu Tian , Tudor Gregory , Defnet Amy E. , Zalesak Stephanie , Kumar Praveen , Booth Catherine , Farese Ann M. , MacVittie Thomas J. , Kane Maureen A. 
Published: September 2020

Abstract
Exposure to ionizing radiation results in injuries of the hematopoietic, gastrointestinal, and respiratory systems, which are the leading causes responsible for morbidity and mortality. Gastrointestinal injury occurs as an acute radiation syndrome. To help inform on the natural history of the radiation-induced injury of the partial body irradiation model, we quantitatively profiled the proteome of jejunum from non-human primates following 12 Gy partial body irradiation with 2.5% bone marrow sparing over a time period of 3 wk. Jejunum was analyzed by liquid chromatography-tandem mass spectrometry, and pathway and gene ontology analysis were performed. A total of 3,245 unique proteins were quantified out of more than 3,700 proteins identified in this study. Also a total of 289 proteins of the quantified proteins showed significant and consistent responses across at least three time points post-irradiation, of which 263 proteins showed strong upregulations while 26 proteins showed downregulations. Bioinformatic analysis suggests significant pathway and upstream regulator perturbations post-high dose irradiation and shed light on underlying mechanisms of radiation damage. Canonical pathways altered by radiation included GP6 signaling pathway, acute phase response signaling, LXR/RXR activation, and intrinsic prothrombin activation pathway. Additionally, we observed dysregulation of proteins of the retinoid pathway and retinoic acid, an active metabolite of vitamin A, as quantified by liquid chromatography-tandem mass spectrometry. Correlation of changes in protein abundance with a well-characterized histological endpoint, corrected crypt number, was used to evaluate biomarker potential. These data further define the natural history of the gastrointestinal acute radiation syndrome in a non-human primate model of partial body irradiation with minimal bone marrow sparing.
Iontophoresis-Assisted Rose Bengal and Green Light Corneal Cross-Linking
Authors: Tefon Aribaş Atike Burçin , Sarikaya Burcu , Bilgihan Kamil 
Published: September 2020

Purpose:
To evaluate the effects of the application of iontophoresis-assisted rose bengal and green light cross-linking (I-RGX) therapy on enucleated rabbit eyes for corneal biomechanical parameters, dye diffusion rates, and green light levels reaching deep tissues and to compare these parameters with a standard rose bengal and green light cross-linking (RGX) therapy.

Method:
Forty-five enucleated rabbit eyes were used in this study. To evaluate biomechanical changes, corneas were divided into the following 4 groups: the control group, the 0.1% rose bengal application group, the RGX group (100 J/cm2), and the I-RGX group (100 J/cm2). After this, corneal strips were evaluated with a uniaxial extensometer. To assess corneal dye diffusion, postprocedure dye depth was recorded with anterior segment optic coherence tomography. The amount of irradiation passing through the cornea during irradiation with 250 mW/cm2 irradiation power was measured with a laser power meter at the first, third, and seventh minutes.

Results:
In the I-RGX–treated group especially, the mean elastic modulus and corneal stiffness values were about 4.7 times higher when compared with the controls and about 2.2 times higher than those in the RGX group. The rose bengal diffusion depth was 26.63% ± 3.84% of the total corneal thickness in the rose bengal drop group, but this value increased to 42.22% ± 4.77% in the iontophoresis group (<0.001). After iontophoresis, an average of 98% of the 100 J/cm2 green light was kept in the cornea.

Conclusions:
I-RGX is a very useful method for increasing corneal biomechanical strength and is highly effective in increasing the amount of corneal dye diffusion into the cornea while also minimalizing the amount of laser passage reaching deeper tissues.
Resveratrol Rescues Human Corneal Epithelial Cells Cultured in Hyperosmolar Conditions: Potential for Dry Eye Disease Treatment
Authors: Shetty Rohit , Subramani Murali , Murugeswari Ponnalagu , Anandula Venkata Ramana , Matalia Himanshu , Jayadev Chaitra , Ghosh Arkasubhra , Das Debashish 
Published: September 2020

Purpose:
Dry eye disease (DED) is a common ocular surface condition across age groups. Recently, vitamin D deficiency has gained importance as a causative factor, and its supplementation alleviates symptoms of DED. Resveratrol (RES) regulates vitamin D receptors (VDRs) and Notch signaling. We investigated the role of RES on vitamin D levels and Notch signaling under hyperosmolar conditions.

Methods:
Human corneal epithelial (HCE-T) cells were treated with RES in hyperosmolar and normal conditions. Quantitative real-time polymerase chain reaction (PCR), immunofluorescence, enzyme-linked immunosorbent assay, and western blot analysis were performed for estimating reactive oxygen species, VDR, secreted 25-hydroxyvitamin D3, and Notch signaling pathway molecules in treated and control cells.

Results:
HCE-T cells in hyperosmolar conditions had increased reactive oxygen species levels and decreased vitamin D levels that got restored in the presence of RES. Hyperosmolarity also reduced VDR expression and Notch activity that normalized to original levels with RES. In the presence of Notch blocker LY-411575, RES could not restore VDR expression or secreted vitamin D levels in HCE-T cells exposed to hyperosmolar conditions, whereas recombinant Jagged1 restored vitamin D and VDR levels.

Conclusions:
RES restores vitamin D levels in hyperosmolar conditions most likely through activation of Notch signaling. Hence, RES can be a potential adjuvant in DED for patients considered for vitamin D treatment.
Presumed Herpes Zoster Ophthalmicus Reactivation Following Recombinant Zoster Vaccination
Authors: Jabbour Samir , Shekhawat Nakul S. , Chen Ariel , Woreta Fasika A. 
Published: September 2020

Purpose:
To report a case of herpes zoster ophthalmicus (HZO) reactivation after recombinant zoster vaccination.

Methods:
A 78-year-old woman, with a history of HZO 20 years ago, was referred for progressive corneal thinning in her left eye that started 1 week after her second dose of recombinant zoster vaccination.

Results:
At presentation, visual acuity was counting fingers. Corneal sensation was markedly decreased. Slit lamp examination revealed a temporal paracentral epithelial defect 1.5 × 2.0 mm in size with 40% thinning and surrounding stromal inflammation suggestive of stromal keratitis with ulceration. The patient was started on oral valacyclovir, topical erythromycin ointment, and hourly topical lubrication. A bandage contact lens was placed and was replaced 1 week later with self-retained cryopreserved amniotic membrane ring. The ring was removed in the following week when the thinned area was epithelialized with no further evidence of stromal lysis.

Conclusions:
HZO reactivation after recombinant zoster vaccination is uncommon but possible. Ophthalmologists should remain aware of potential risks of zoster vaccination and take special precautions in patients with HZO history.
Child Labor Trafficking Essentials for Forensic Nurses
Authors: Hornor Gail 
Published: September 2020

ABSTRACT
Human trafficking is a form of modern-day slavery and is a significant pediatric healthcare problem in the United States. The term “human trafficking” encompasses both sex and labor trafficking. Sex trafficking, especially child sex trafficking, has received significant lay and professional attention. However, few efforts have focused on learning more about youth experiencing labor trafficking in the United States. Pediatric healthcare providers, including forensic nurses, are likely to encounter victims of child labor trafficking in their practice. A basic understanding of child labor trafficking will assist forensic nurses in timely identification of and appropriate intervention for victims. In this article child labor trafficking is discussed in terms of definition, epidemiology, history, risk factors, consequences, identification, and implications for practice.
Rising Rate of Obesity in Patients Admitted for Crohn’s Disease Increases Costs But Not Mortality
Authors: Lipcsey Megan , Stein Daniel J. , DeVore Zachary G. , Feuerstein Joseph D. 
Published: September 2020

Goal:
The goal of this study was to compare outcomes and trends for inpatients with Crohn’s disease (CD) and obesity.

Background:
Obesity is a growing concern in the United States. Current data on the effect of obesity on the course of the CD are conflicted.

Methods:
Data from the 2016 to 2017 National Inpatient Sample were compared for obese, normal weight, and malnourished patients. After adjustment for comorbidities, demographics and disease type/inpatient surgery, outcomes including mortality, length of stay, hospitalization charges, and rates of deep venous thrombosis (DVT) in obese and malnourished patients were compared with those with normal body mass index using multivariable regression. For trend analysis, rates of obesity were compared from 2002 to 2017.

Results:
The percentage of patients with CD and obesity increased from 1.8% in 2002 to 9.5% in 2017 (0.5% per year, P<0.001). Rates of death were similar in obese versus normal-weight CD patients [odds ratio (OR)=1.21, 95% confidence interval (CI): 0.85-1.73, P=0.288]. In contrast, obese CD patients had increased length of stay (1.0 d, 95% CI: 0.81-1.26, P<0.001), cost ($8323, 95% CI: 5565-11,082, P<0.001), and DVT rate (OR=1.67, 95% CI: 1.13-2.46, P=0.01). Malnourished CD patients had OR for death of 2.15 (95% CI: 1.71-2.70, P<0.001) compared with normal-weight cohort. Similarly, length of stay, cost, and DVT rate were all increased.

Conclusions:
Rates of hospitalized CD patients with obesity are increasing. Patients with obesity and CD have increased length of stay and costs, with no mortality difference. Malnourished CD patients continue to have higher mortality, length of stay, and cost. Obesity is a risk factor for adverse hospitalization outcomes.
The Preventive and Control Recommendations on Patient With Cleft Lip and Palate During COVID-19 Pandemic in Shanghai
Authors: Cai Ming , Zhao Xinran , Chen Liqin , Yuan Weijun , Wang Guomin , Wang Xudong 
Published: September 2020

Abstract
As Corona Virus Disease 2019 (COVID-19) has been gradually controlled domestically, various industries began to resume production in an orderly way. Attention should be paid to the disease and population characteristics of patients with cleft lip with/without palate during diagnosis and treatment. This article summarized and provided prevention and control recommendations on management strategies during hospitalization and protective measures of patients and healthcare workers, hoping to minimize the spread of disease and create a relatively safe environment for medical work.
Molecular identification, genotypic heterogeneity and comparative pathogenicity of environmental isolates of Papiliotrema laurentii
Authors: Asadzadeh Mohammad , Ahmad Suhail , Khan Ziauddin , Verghese Soumya , Joseph Leena 
Published: September 2020

Introduction.Papiliotrema laurentii, formerlyCryptococcus laurentii, is typically isolated from environmental sources, but also occasionally from clinical specimens. Other close relatives may be misidentified asP. laurentiiby phenotypic methods.P. laurentiiusually lacks melanin; however, melanin-forming strains have also been isolated.Hypothesis/Gap Statement.Although melanin production by encapsulated budding yeasts is considered a major virulence factor, the comparative pathogenicity of melanin-forming and non-melanized environmental strains ofP. laurentiihas rarely been studied.Aim.We performed phenotypic and molecular identification and determined the genotypic heterogeneity amongP. laurentiiisolates. We also studied the pathogenicity of melanin-forming and non-melanized strains in normal and immunosuppressed mice.Methodology.Eleven environmental isolates were tested for their identity by Vitek2 and/or ID32C systems, and by PCR-sequencing of the internal transcribed spacer (ITS) region and D1/D2 domains of ribosomal DNA (rDNA). Genotypic heterogeneity was studied by sequence comparisons. The pathogenicity of melanized and non-melanizedP. laurentiistrains was studied in intravenously infected normal and immunosuppressed BALB/c mice.Results.Phenotypic methods identified seven of the environmental isolates, while PCR-sequencing of the ITS region and D1/D2 domains of rDNA detected two and five isolates, respectively, asP. laurentii. Sequence comparisons demonstrated genotypic heterogeneity amongP. laurentii. The remaining four environmental isolates yielded expected results. None of the normal mice infected with 105 cells of melanized/non-melanizedP. laurentiistrains died. Infection of immunosuppressed mice with 107 cells caused higher mortality with non-melanizedP. laurentii, while viable counts in brain/lung tissue were higher in mice infected with a melanized strain and were detectable for up to 14 days.Conclusion.Phenotypic methods lacked specificity, but PCR-sequencing of D1/D2 domains correctly identifiedP. laurentiiand sequence comparisons demonstrated the genotypic heterogeneity of the isolates. Both melanized and non-melanized strains at a higher dose caused mortality in immunosuppressed mice and persisted in brain/lung tissue up to 14 days post-infection.
Prediction of Covid-19 Infections Through December 2020 for 10 US States Incorporating Outdoor Temperature and School Re-Opening Effects-August Update
Authors: Newell Ty 
Published: September 2020

AbstractEnd-of-August updates for Covid-19 infection case predictions for 10 US States (NY, WA, GA, IL, MN, FL, OH, MI, CA, and NC) are compared to actual data. Several states that experienced significant summer surges gained control of accelerating infection spread during August. The US as a whole and the 10 States investigated continue to follow periods of linear infection growth that defines a boundary separating accelerated infection growth and infection decay.August 31 predictions (initiated July 27, 2020) for four States (NY, WA, MI and MN) are within 10% of actual data. Predictions for four other States (GA, IL, CA, and OH) agree between 10 and 20% of actual data. Predictions for two States (FL and NC) are greater than 20% different from actual data. Systematic differences between predictions and actual data are related to the impact of the June-July summer surge, and human behavior reactions (ie, increased face mask usage and distancing) to accelerated infection growth.Outdoor temperature effects and school re-opening effects are not apparent nor expected for August. Human behavior parameters (Social Distance Index, SDI, and disease transmission efficiency, G, parameters) are adjusted to mirror August data. Comparisons of actual versus predicted daily new infection cases display the complexity of SARS-CoV-2 transmission.
Dual Attention Multiple Instance Learning with Unsupervised Complementary Loss for COVID-19 Screening
Authors: Chikontwe Philip , Luna Miguel , Kang Myeongkyun , Hong Kyung Soo , Ahn June Hong , Park Sang Hyun 
Published: September 2020

AbstractChest computed tomography (CT) based analysis and diagnosis of the Coronavirus Disease 2019 (COVID-19) plays a key role in combating the outbreak of the pandemic that has rapidly spread worldwide. To date, the disease has infected more than 18 million people with over 690k deaths reported. Reverse transcription polymerase chain reaction (RTPCR) is the current gold standard for clinical diagnosis but may produce false positives; thus, chest CT based diagnosis is considered more viable. However, accurate screening is challenging due to difficulty in annotation efforts of infected areas, curation of large datasets, and the slight discrepancies between COVID-19 and other viral pneumonia. In this study, we propose an attention-based end-to-end weakly supervised framework for the rapid diagnosis of COVID-19 and bacterial pneumonia based on multiple instance learning (MIL). We further incorporate unsupervised contrastive learning for improved accuracy with attention applied both in spatial and latent contexts, herein we propose Dual Attention Contrastive based MIL (DA-CMIL). DA-CMIL takes as input a several patient CT slices (considered as a bag of instances) and outputs a single label. Attention based pooling is applied to implicitly select key slices in latent space, and spatial attention learns slice spatial context for interpretable diagnosis. A contrastive loss is applied at the instance level to encode similarity in features from the same patient against pooled patient features. Empirical results show our algorithm achieves an overall accuracy of 98.6% and an AUC of 98.4%. Moreover, ablation studies show the benefit of contrastive learning with MIL.
Application of interpretive structural modelling for analysis of lean adoption barriers in heavy industry
Authors: B.G. Aadithya , P. Asokan , Vinodh S. 
Published: September 2020

Purpose
The purpose of the paper is to depict a study on analysis of barriers to lean adoption in fabrication industry using interpretive structural modelling (ISM).

Design/methodology/approach
From the literature review, 22 barriers to lean adoption in fabrication industry have been recognized . Self-structure interaction matrix has been developed based on expert opinion. Computational steps of ISM are being done to develop the structural model. cross-impact matrix multiplication applied to classification (MICMAC) analysis is being done to group the barriers into four types.

Findings
Based on the study, it has been found that “lack of knowledge about lean (philosophy, principles, tools)”, “lack of top management support and commitment” and “poor leadership” are found to be the principal barriers. MICMAC analysis indicated that number of driving, dependent, linkage and autonomous barriers are 9, 8, 4 and 1, respectively.

Practical implications
The study has been executed based on the inputs from industrial practitioners and hence the inferences are found to have practical relevance.

Originality/value
The study is an attempt to analyze the barriers for lean concepts adoption in fabrication kind of industry.
Editorial: service research in the new (post-COVID) marketplace
Authors: Rosenbaum Mark Scott , Russell-Bennett Rebekah 
Published: September 2020

Purpose
The aim of this paper is to encourage service researchers to consider the long-term or permanent impact of the coronavirus-2019 (COVID-19) on services, service delivery, organizational structures, service providers and service systems from global perspectives.

Design/methodology/approach
This editorial is based on the personal reflections of the Journal of Services Marketing editors.

Findings
The services marketing discipline emerged in a time when customers and employees were encouraged to engage in social interaction and to form relationships, as many service encounters were deemed as social encounters. COVID-19 has impacted the ability of customers and employees to freely engage in social interaction, and as a result, we need to consider the steadfastness of our foundational theories and conceptual models in the “new” marketplace.

Research limitations/implications
The editors put forth a series of sixteen research questions that warrant future empirical and descriptive research.

Practical implications
Managers can understand how COVID-19 will profoundly impact dramatic changes in the marketplace and prepare for them.

Originality/value
This study suggests that our theoretical and practical understandings of service industries has been significantly impacted by COVID-19.
The institutionalization of management control systems in a family firm
Authors: Pagliarussi Marcelo S. , Leme Michel A. 
Published: September 2020

PurposeThis study aims to understand how family values, family managers and non-family managers influence the institutionalization of management control systems in family firms.Design/methodology/approachA case study was conducted in a family business group that underwent a process of adoption and transformation of its management control system.FindingsThe results indicate that several non-family managers, besides the controller, played crucial roles in harmonizing the logic of a generalized practice (quality control management) with the existing rationalities of the family firm. The authors also observed that the ISO 9001/quality control management logic together with the family values of professionalism, meritocracy and an emphasis on the business’s identity rather than the family identity have laid the groundwork for the formalization of the business group’s management controls.Practical implicationsThis study shows that quality control management is an accessible source of guidance for the formalization of managerial activities within an organization.Originality/valueThis paper contributes to the literature by clarifying the role performed by non-family managers during the formalization of management control in family firms. It also shows how the family values of professionalism, meritocracy and an emphasis on the business’s identity rather than family identity can influence the way control is exercised within family firms.
Using non‐mydriatic fundus photography to detect fundus pathology in Australian metropolitan emergency departments: A prospective prevalence and diagnostic accuracy study
Authors: Dunn Hamish P , Teo Kai Zong , Smyth James WP , Weerasinghe Lakni S , Costello Julia , Pampapathi Preethi , Keay Lisa , Green Tim , Vukasovic Matthew , Bruce Beau B , Newman Nancy J , Biousse Valérie , White Andrew J , McCluskey Peter , Fraser Clare L 
Published: September 2020

AbstractObjectiveTo determine the prevalence of fundus pathology in metropolitan Australian EDs utilising a non‐mydriatic fundus photography screening programme. Secondary objectives include diagnostic accuracy among emergency physicians compared to telehealth ophthalmologist review.MethodsProspective cross‐sectional study investigating non‐mydriatic fundus photography as a new diagnostic test in two tertiary Australian EDs. Consecutive adult patients were enrolled if they presented with headache, focal neurological deficit, visual disturbance or diastolic BP >120 mmHg. Diagnostic agreement was determined using kappa statistics and sensitivity and specificity using a reference standard consensus ophthalmology review.ResultsA total of 345 consecutive patients were enrolled among whom 56 (16%, 95% confidence interval [CI] 13–21) had urgent fundus pathology. Agreement between emergency physician and ophthalmic assessment of fundus photographs was 74% (kappa = 0.196, P = 0.001). Emergency physicians had 40% sensitivity (95% CI 27–54) and 82% specificity (95% CI 76–86) for detecting urgent pathology on photographs.ConclusionsFundus photography detects a clinically significant proportion of fundus pathology and urgent diagnoses. Telehealth specialist image review is important to detect some important, time‐critical illnesses that can be missed in routine care. This offers an accurate alternative to direct ophthalmoscopy that warrants further research in Australian EDs.