bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meeting of the minds: research priorities for value co-creation in dialogical conferences
Authors: Parkinson Joy , Davey Janet 
Published: December 2020

Purpose
This paper aims to explain the development of the dialogical conference, develop a framework for understanding the social construction of the dialogical conference and provide research priorities for further developing the practice in the services marketing discipline.

Design/methodology/approach
The growing challenge for service researchers is to generate new theory and knowledge to solve complex problems. Dialogical conferences offer an avenue to develop solutions in response to this challenge. Value co-creation provides a useful lens through which to view dialogical conferences. We draw on Ranjan and Read’s (2016) value-in-use and value co-production and Ramaswamy and Ozcan’s (2018) interactive engagement platforms for value co-creation. Mindful of the contributions of both, the paper presents an integrative framework that describes the relationships between the concepts to provide a firm grounding for developing dialogical conferences.

Findings
By mapping value co-creating activities in dialogical conferences according to the APPI framework – artifacts, persons, processes and interfaces – on to value-in-use and value co-production, we propose a new category of value-in-use, equality, to the conceptualisation of value co-creation outcomes. Equality in contribution, attribution and effort is under-represented in value co-creation.

Originality/value
Dialogical conferences are increasingly important for knowledge generation and creating potential for action, yet are underexplored in service research. This paper contributes to the literature by using service logic and dialogical conferences to extend our knowledge of value co-creation interactive platforms and outcomes. Second, we demonstrate the value of dialogical conferences for facilitating meaningful service research and knowledge development. Finally, the authors identify research priorities to encourage further work on extending the understanding and application of dialogical interactive platforms and value co-creation to enable the service community to be responsive in solving complex problems through service offerings.
Assessment of healthcare solid waste management practices for environmental performance: a study of hospitals in Himachal Pradesh, India
Authors: Thakur Vikas , Sharma Somesh 
Published: December 2020

PurposeThe day-by-day escalating quantity of healthcare waste (HCW), has made waste handling and management a challenging issue for ensuring environmental quality. Developing nations like India face huge difficulties in handling healthcare solid wastes (HCSW) because of the extra population burden. Hence, the present study seeks to evaluate the role of various stakeholders, under the following four performance areas: “collection and segregation of HCSW,” “storage and transportation of HCSW,” “special measures for handling HCSW” and ‘awareness among the various stakeholders of handling and managing the HCSW.”Design/methodology/approachThe study targets the primary data from 323 stakeholders across 35 hospitals in Himachal Pradesh, India, to assess the environmental awareness level among various stakeholders. Data were analyzed using preliminary descriptive statistics, and further statistical testing was done using one-way ANOVA in SPSS version 20.0.FindingsResults highlight that most hospitals lack the following areas: segregation of HCSW, marking of zones and bags carrying infectious HCSWs, inadequate transportation facilities, bad handling and storage practices and recycling without chemical disinfection.Practical implicationsThe study's findings will help the hospitals' administration and State Pollution Control Board to design training programs for all the stakeholders involved in managing HCSW. The proper recycling of the HCSW will reduce the adverse environmental impact and ensure the environmental quality within the hospitals and surroundings. The preparation of appropriate policy for the collection, storage and transportation of HCSW from the hospitals to the treatment centers will ensure the cleaner delivery of healthcare services to society.Originality/valueThe present study is the first of its kind, where the primary data were collected from the various stakeholders involved in the handling of HCSW at various healthcare establishments (HCEs) in Himachal Pradesh, India.
Site fertility and soil water‐table level affect fungal biomass production and community composition in boreal peatland forests
Authors: Peltoniemi Krista , Adamczyk Sylwia , Fritze Hannu , Minkkinen Kari , Pennanen Taina , Penttilä Timo , Sarjala Tytti , Laiho Raija 
Published: December 2020

SummaryA substantial amount of below‐ground carbon (C) is suggested to be associated with fungi, which may significantly affect the soil C balance in forested ecosystems. Ergosterol from in‐growth mesh bags and litterbags was used to estimate fungal biomass production and community composition in drained peatland forests with differing fertility. Extramatrical mycelia (EMM) biomass production was generally higher in the nutrient‐poor site, increased with deeper water table level and decreased along the length of the recovery time. EMM biomass production was of the same magnitude as in mineral‐soil forests. Saprotrophic fungal biomass production was higher in the nutrient‐rich site. Both ectomycorrhizal (ECM) and saprotrophic fungal community composition changed according to site fertility and water table level. ECM fungal community composition with different exploration types may explain the differences in fungal biomass production between peatland forests. Melanin‐rich Hyaloscypha may indicate decreased turnover of biomass in nutrient‐rich young peatland forest. Genera Lactarius and Laccaria may be important in nutrient rich and Piloderma in the nutrient‐poor conditions, respectively. Furthermore, Paxillus involutus and Cortinarius sp. may be important generalists in all sites and responsible for EMM biomass production during the first summer months. Saprotrophs showed a functionally more diverse fungal community in the nutrient‐rich site.
Reading for pleasure among Jordanian children: a community‐based reading intervention
Authors: Mahasneh Randa , von Suchodoletz Antje , Larsen Ross A.A. , Dajani Rana 
Published: December 2020

BackgroundWe Love Reading (WLR) is a community‐based reading intervention aimed at cultivating an interest in reading for pleasure among children through mobilising local community members to establish informal libraries and organise read‐aloud sessions in public spaces. The programme targets primarily children between the ages 4–10 but is also open to older children. The present study investigated the effect of the WLR programme on children's practices and attitudes related to reading for pleasure.MethodsParticipants were 1,718 children recruited from different regions in Jordan. Children were, on average, 7.52 years old (SD = 2.12). The treatment group comprised 1,304 children (59% girls; Mage = 7.18 years, SD = 2.16) who received the WLR programme over 4 months. The comparison group comprised 414 children (59% girls; Mage = 8.50 years, SD = 1.67) who did not attend any reading programme. Two assessment tools, adapted from previous literature, assessed reading attitudes and reading practices. The structural equation modelling framework was used to analyse the data.ResultsResults showed a small but significant increase in reading attitude scores and reading practice scores among children who participated in the WLR programme. The positive effect was found for children of all ages and for boys and girls alike.ConclusionA comparison of scores between the WLR group and the comparison group showed a small advantage for the WLR group. The results provide initial support for the WLR programme as a promising community‐based reading intervention for promoting reading for pleasure among children.
Quercetin induces p53‐independent cancer cell death through lysosome activation by the transcription factor EB and Reactive Oxygen Species‐dependent ferroptosis
Authors: Wang Zi‐Xuan , Ma Jing , Li Xin‐Yu , Wu Yong , Shi Huan , Chen Yao , Lu Guang , Shen Han‐Ming , Lu Guo‐Dong , Zhou Jing 
Published: December 2020

Background and PurposeCancer cells exhibit more dependence on iron and enhanced sensitivity to iron‐dependent, programmed cell death (ferroptosis) than normal cells. Quercetin exerts anti‐cancer effects, but the underlying molecular mechanism is largely unknown. In this study, we aimed to investigate the involvement of lysosome function and ferroptosis in the anti‐cancer potential of quercetin.Experimental ApproachWe used MTT assays and DNA content analysis to evaluate the cytotoxicity, colony formation assay to investigate cell proliferation, and flow cytometry and confocal microscopy to detect lysosomal acidification and protease enzyme activity. Western blotting, cell subfractionation, RT‐PCR and siRNA transfection were used to establish molecular mechanisms of action.Key ResultsQuercetin is known to promote p53‐independent cell death in various cancer cell lines. Although quercetin induces autophagy, genetic silencing of Atg7 fails to affect quercetin‐induced cell death. In contrast, both lysosome inhibitors and knockdown of the transcription factor EB can prevent quercetin‐induced cell death, suggesting the involvement of lysosome. Next, quercetin is found to induce lysosomal activation sequentially through nuclear translocation of EB and transcriptional activation of lysosomal genes. Notably, quercetin promoted lysosome‐dependent ferritin degradation and free iron release. This action and quercetin‐induced ROS generation synergistically resulted in lipid peroxidation and ferroptosis. Furthermore, Bid may link ferroptosis with apoptosis to cause cell death.Conclusion and ImplicationsQuercetin induced EB‐mediated lysosome activation and increased ferritin degradation leading to ferroptosis and Bid‐involved apoptosis. Results from this study may expand our current knowledge about the mechanism of quercetin as an anti‐cancer agent.
Analysis of colectomy rates for ulcerative colitis in pre‐ and postbiological eras in Lothian, Scotland
Authors: Jenkinson Philip W. , Plevris Nikolas , Lyons Mathew , Grant Rebecca , Fulforth James , Kirkwood Kate , Arnott Ian D. , Wilson David , Watson Angus J. M. , Jones Gareth‐Rhys , Lees Charlie W. 
Published: December 2020

AbstractAimBiological treatment is effective in maintaining remission in ulcerative colitis (UC), although the effect on colectomy rates remains unclear. In the UK the use of antitumour necrosis factor and anti‐α4β7 treatments for maintenance therapy in UC was restricted until 2015. The aim of this study was to describe the impact that this change in the prescribing of biologicals had on colectomy rates for UC.MethodAll patients (adult and paediatric) with a diagnosis of UC who received maintenance biological treatment and/or underwent a colectomy in Lothian, Scotland between 2005 and 2018 were identified. Linear and segmental regression analyses were used to identify the annual percentage change (APC) and temporal trends (statistical joinpoints) in biological prescription and colectomy rates.ResultsRates of initiation of maintenance biological therapy increased from 0.05 per 100 UC patients in 2005 to 1.26 in 2018 (p < 0.001). Colectomy rates per 100 UC patients fell from 1.47 colectomies in 2005 to 0.44 in 2018 (p < 0.001). The APC for colectomy decreased by 4.1% per year between 2005 and 2014 and by 18.9% between 2014 and 2018. Temporal trend analysis (2005–2018) identified a significant joinpoint in colectomy rates in 2014 (p = 0.019).ConclusionThe use of maintenance biological therapy increased sharply following the change in guidance. This has been paralleled by a significant reduction in the rates of colectomy over the same time period.
Chest pain and palpitations in postmenopausal women with mitral valve prolapse: is there a gastro‐oesophageal origin?
Authors: Maiello Maria , Zito Annapaola , Cecere Annagrazia , Ciccone Marco Matteo , Palmiero Pasquale 
Published: December 2020

AbstractBackground and aimMitral valve prolapse (MVP) is a common disease in women, causing chest pain and palpitation due to structural and functional valve abnormality, and is sometimes associated with gastro‐oesophageal reflux disease (GERD). This is a challenging clinical problem in clinical practice and requires targeted diagnostic assessment to identify the underlying causes of the symptoms, because treatment needs to be tailored, according to the causes themselves, to resolve the symptoms.AimTo assess the prevalence of GERD in a population of postmenopausal women affected by MVP and determine if there is any correlation between the two conditions.MethodsThe MVP diagnosis was performed using echocardiograpy examination, according to American Society Echocardiography criteria. Two hundred and eighty‐nine consecutive MVP women, symptomatic for chest pain and palpitation, were included; 250 consecutive women without MVP, symptomatic for chest pain and palpitation, were the control group (CG). The GERD diagnosis was made according to 2013 American College Gastroenterology criteria; women affected by thyroid disorders, all heart disease, including mitral disease with moderate or severe mitral regurgitation, and gastrointestinal diseases assessed using gastroscopy were excluded.ResultsAmong 289 women with MVP, 31 (11%) women were affected by GERD, and among 250 in the CG, 11 (4.4%) women were affected by GERD: Chi‐squared 8.1; odds ratio 2.7; P < 0.0044. Twenty‐six (9%) women affected by GERD, with MVP, presented with mild mitral regurgitation, and 7 (2.8%) women in the CG presented with mild mitral regurgitation as well: Chi‐squared 8.95; odds ratio 3.4; 95% CI, P < 0.0028.Discussion and conclusionsGERD is relatively common in women with MVP. Moreover, women with MVP are approximately three times more likely to be affected by GERD; the two conditions are correlated in a statistically high significant way. GERD assessment needs to be included into routine follow‐up strategies in women with MVP to optimise medical therapy, improvinge symptom relief for better quality of life.
EuroGuiDerm Guideline on the systemic treatment of Psoriasis vulgaris – Part 1: treatment and monitoring recommendations
Authors: Nast A. , Smith C. , Spuls P.I. , Avila Valle G. , Bata‐Csörgö Z. , Boonen H. , De Jong E. , Garcia‐Doval I. , Gisondi P. , Kaur‐Knudsen D. , Mahil S. , Mälkönen T. , Maul J.T. , Mburu S. , Mrowietz U. , Reich K. , Remenyik E. , Rønholt K.M. , Sator P.G. , Schmitt‐Egenolf M. , Sikora M. , Strömer K. , Sundnes O. , Trigos D. , Van Der Kraaij G. , Yawalkar N. , Dressler C. 
Published: December 2020

AbstractThis evidence‐ and consensus‐based guideline on the treatment of psoriasis vulgaris was developed following the EuroGuiDerm Guideline and Consensus Statement Development Manual. The first part of the guideline includes general information on the scope and purpose, health questions covered, target users and strength/limitations of the guideline. Suggestions for disease severity grading and treatment goals are provided. It presents the general treatment recommendations as well as detailed management and monitoring recommendations for the individual drugs. The treatment options discussed in this guideline are as follows: acitretin, ciclosporin, fumarates, methotrexate, adalimumab, apremilast, brodalumab, certolizumab pegol, etanercept, guselkumab, infliximab, ixekizumab, risankizumab, secukinumab, tildrakizumab and ustekinumab.
Personal Initiative, Passive‐Avoidant Leadership and Support for Innovation as Antecedents of Nurses’ Idea Generation and Idea Implementation
Authors: Zappalà Salvatore , Toscano Ferdinando , Polevaya Marina V. , Kamneva Elena V. 
Published: December 2020

ABSTRACTPurposeThis study aims to explore the role of individual (work engagement, personal initiative), group (transformational, transactional, passive‐avoidant leadership) and organisational factors (support for innovation climate) in fostering the two components of nurses’ innovative behaviours, idea generation and idea implementation.Design and MethodA cross‐sectional study was conducted in an Italian public hospital, in two departments that had been created by merging other departments. A self‐report questionnaire was completed by 118 nurses. Hierarchical regression analysis was used to test the hypotheses.FindingsRespondents reported a high frequency of idea generation followed by idea implementation. Personal initiative and passive‐avoidant leadership were significantly and positively related to nurses’ idea generation and idea implementation. Support for innovation was positively related to idea implementation. Transactional and transformational leadership did not show any relationships with the two innovative work behaviours.ConclusionsThis study shows that nurses’ innovative work behaviour is a complex and multi determined behaviour, influenced by individual, group, and organisational factors. It also shows that low levels of passive‐avoidant leadership may contribute to innovation.Clinical RelevanceHealthcare policies and strategies are needed to support a leadership style that allows space for autonomy, and that, together with support for innovation and personal initiative, facilitates nurses’ idea generation and idea implementation.
Nationwide study of mortality and survival in pregnancy‐related streptococcal toxic shock syndrome
Authors: Hayata Eijiro , Nakata Masahiko , Hasegawa Junichi , Tanaka Hiroaki , Murakoshi Takeshi , Mitsuda Nobuaki , Sekizawa Akihiko , Ikeda Tomoaki , Ishiwata Isamu 
Published: December 2020

AbstractAimStreptococcal toxic shock syndrome is associated with the highest infection‐related maternal mortality rates. We conducted a comparative analysis of the background factors and treatment course between survivors and nonsurvivors to improve our understanding concerning the optimal initial treatment approach for this fulminant disease.MethodsThis retrospective observational study was conducted based on clinical data collected from two national organizations. Clinical data of patients who died or survived (i.e. background information, clinical course and treatment administered) were collected.ResultsRecords of 13 dead and 15 surviving patients were collected and analyzed. No statistically significant differences were found between the groups regarding age, parity, season, gestational age or the patients' location at the onset of symptoms. After the initial symptom onset, the survivors received antibiotics more systematically during their first visit to a clinic (P = 0.006). More survivors had received treatment within 1 h of onset of fulminant disease (P = 0.069). The number of fetal deaths was significantly higher in the mortality group (P = 0.003), while the fetal survival number was higher in the group of maternal survivors (P = 0.055). Maternal survivors with nonspecific initial symptoms received early intervention when there was a family history of group A streptococcal infection or a positive rapid antigen test result.ConclusionIntensive care, including systemic antibiotic administration, may contribute to maternal survival when administered immediately (within 1 h) after the fulminant streptococcal toxic shock syndrome onset. Eliciting a family history of streptococcal infection and conducting a rapid antigen test can identify the patients needing early intervention.
High serum creatinine concentration is associated with metabolic perturbations in dogs
Authors: Ottka Claudia , Vapalahti Katariina , Määttä Ann‐Marie , Huuskonen Nanna , Sarpanen Sinikka , Jalkanen Liisa , Lohi Hannes 
Published: December 2020

AbstractBackgroundThe kidneys have many essential metabolic functions, and metabolic disturbances during decreased renal function have not been studied extensively.ObjectivesTo identify metabolic changes in blood samples with increased serum creatinine concentration, indicating decreased glomerular filtration.AnimalsClinical samples analyzed using a nuclear magnetic resonance (NMR) based metabolomics platform. The case group consisted of 23 samples with serum creatinine concentration >125 μmol/L, and the control group of 873 samples with serum creatinine concentration within the reference interval.MethodsBiomarker association with increased serum creatinine concentration was evaluated utilizing 3 statistical approaches: Wilcoxon rank‐sum test, logistic regression analysis (false discovery rate (FDR)‐corrected P‐values), and random forest classification. Medians of the biomarkers were compared to reference intervals. A heatmap and box plots were used to represent the differences.ResultsAll 3 statistical approaches identified similar analytes associated with increased serum creatinine concentrations. The percentages of citrate, tyrosine, branched‐chain amino acids, valine, leucine, albumin, linoleic acid and the ratio of phenylalanine to tyrosine differed significantly using all statistical approaches, acetate differed using the Wilcoxon test and random forest, docosapentaenoic acid percentage only using logistic regression (P < .05), and alanine only using random forest.Conclusions and Clinical ImportanceWe identified several metabolic changes associated with increased serum creatinine concentrations, including prospective diagnostic markers and therapeutic targets. Further research is needed to verify the association of these changes with the clinical state of the dog. The NMR metabolomics test is a promising tool for improving diagnostic testing and management of renal diseases in dogs.
Dietary adequacy and nutritional status of Meitei community of Manipur, Northeast India
Authors: Loukrakpam Bidyalakshmi , Rajendran Ananthan , Madhari Radhika S. , Boiroju Naveen Kumar , Longvah Thingnganing 
Published: December 2020

AbstractMeitei is the main ethnic community that belongs to the north‐eastern state of Manipur in India. This community is bestowed with rich biodiverse resources with indigenous foods still form an integral part of their diet. However, limited data on the food and nutrient consumption as well as nutritional status of this community are available. This study was carried out on the children, adolescents and women of reproductive age (WRA) of this community from 12 villages, to determine their food consumption pattern and nutritional status. Basic anthropometry and 24‐h dietary intake assessment was conducted. The prevalence of underweight was 27%, stunting was 45% and wasting was 12% in children below 5 years. Stunting was observed among 34% of children 5–17 years of age. About 7% of WRA were undernourished, while 28% were overweight or obese. About 55% of 1–7 year‐old children had mean probability adequacy of 12 micronutrients <0.5, and the adequacy of individual micronutrients namely vitamin A, E and calcium were low. Dietary determinants such as low dietary diversity score, dietary species richness and the lowest tertiles of different food groups' intake (except for sugars, fish and sea foods and spices and condiments) predicted micronutrient inadequacy. In addition to a high prevalence of undernutrition in children and adolescents and overnutrition in WRA, the effect of various dietary determinants on micronutrient adequacy in the study group of the Meitei community are reported.