bluuebunny/crossref_metadata_2025_split huggingface dataset:
IL-18 in Blood Serum of Hepatitis C Patients Might be of Predictive Value for Individual Outcomes
Authors: Asadipour Morvarid , Fazeli Pooria , Zohouri Mahshid , Bemani Peyman , Mohebbiniya Mohsen , Khansalar Soolmaz , Fattahi Mohammad Reza , Kalantar Kurosh 
Published: July 2020

Objective:
Pro- inflammatory cytokines including Interleukin (IL)-18 have been shown to be involved in the
clearance of Hepatitis C virus (HCV) infection. However, changes in the balance of pro- and anti-inflammatory cytokines
production during the immune response, can elicit a variety of liver damage. Therefore, it is of interest to study IL-18 serum
levels in hepatitis patients and its correlation with HCV infection.

Methods:
Twenty-nine newly diagnosed HCV+ patients with no history of antiviral therapy, and 17 healthy controls were
enrolled in our study. Biochemical markers of liver disease were evaluated by biochemistry assay kits. Serum concentrations
of IL-18 were determined with the ELISA method before and after treatment with pangenotypic direct‐acting antivirals
(DAAs) treatment.

Results:
Our results showed statistically significant difference in serum levels of IL-18 in HCV+ patients (692.261 ± 48.76)
compared to healthy controls (520.00 ± 44.73) (P=0.021). However, there was no significant difference in IL-18 serum levels between treated group compared to untreated patients (P=0.74). No significant correlations were detected between the
level of IL-18 and liver enzyme levels.

Conclusion:
According to our study, IL-18 might be a disease marker associated with HCV infection; however, this conclusion requires further investigation.
Relationship Between Chronic Stress and Heart Rate Over Time Modulated by Gender in a Cohort of Office Workers: Cross-Sectional Study Using Wearable Technologies
Authors: van Kraaij Alex Wilhelmus Jacobus , Schiavone Giuseppina , Lutin Erika , Claes Stephan , Van Hoof Chris 
Published: July 2020

Background
Chronic stress is increasing in prevalence and is associated with several physical and mental disorders. Although it is proven that acute stress changes physiology, much less is known about the relationship between physiology and long-term stress. Continuous measurement of vital signs in daily life and chronic stress detection algorithms could serve this purpose. For this, it is paramount to model the effects of chronic stress on human physiology and include other cofounders, such as demographics, enabling the enrichment of a population-wide approach with individual variations.

Objective
The main objectives of this study were to investigate the effect of chronic stress on heart rate (HR) over time while correcting for weekdays versus weekends and to test a possible modulation effect by gender and age in a healthy cohort.

Methods
Throughout 2016 and 2017, healthy employees of technology companies were asked to participate in a 5-day observation stress study. They were required to wear two wearables, of which one included an electrocardiogram sensor. The derived HR was averaged per hour and served as an output for a mixed design model including a trigonometric fit over time with four harmonics (periods of 24, 12, 8, and 6 hours), gender, age, whether it was a workday or weekend day, and a chronic stress score derived from the Perceived Stress Scale (PSS) as predictors.

Results
The study included 328 subjects, of which 142 were female and 186 were male participants, with a mean age of 38.9 (SD 10.2) years and a mean PSS score of 13.7 (SD 6.0). As main effects, gender (χ21=24.02, P<.001); the hour of the day (χ21=73.22, P<.001); the circadian harmonic (χ22=284.4, P<.001); and the harmonic over 12 hours (χ22=242.1, P<.001), over 8 hours (χ22=23.78, P<.001), and over 6 hours (χ22=82.96, P<.001) had a significant effect on HR. Two three-way interaction effects were found. The interaction of age, whether it was a workday or weekend day, and the circadian harmonic over time were significantly correlated with HR (χ22=7.13, P=.03), as well as the interaction of gender, PSS score, and the circadian harmonic over time (χ22=7.59, P=.02).

Conclusions
The results show a relationship between HR and the three-way interaction of chronic stress, gender, and the circadian harmonic. The modulation by gender might be related to evolution-based energy utilization strategies, as suggested in related literature studies. More research, including daily cortisol assessment, longer recordings, and a wider population, should be performed to confirm this interpretation. This would enable the development of more complete and personalized models of chronic stress.
Aftercare of Childhood Cancer Survivors in Switzerland: Protocol for a Prospective Multicenter Observational Study
Authors: Denzler Sibylle , Otth Maria , Scheinemann Katrin 
Published: July 2020

Background
Most children and adolescents diagnosed with cancer become long-term survivors. For most of them, regular follow-up examinations to detect and treat late effects are necessary, especially in adulthood. The transition from pediatric to adult-focused follow-up care is a critical moment for childhood cancer survivors (CCSs); a substantial proportion of CCSs are lost to follow-up in this transition process and do not attend follow-up care in adulthood. This can have serious effects on survivors’ health if late effects are not discovered in a timely fashion.

Objective
In this study, we primarily assess the current follow-up situation, related needs, and knowledge of adolescent and young adult CCSs who have transitioned from pediatric to adult-focused follow-up care. As secondary objectives, we evaluate transition readiness, identify facilitating factors of transition and adherence to long-term follow-up (LTFU) care, and compare three different transition models.

Methods
The Aftercare of Childhood Cancer Survivors (ACCS) Switzerland study is a prospective, multicenter, observational study that was approved by the ethics committee in February 2019. We are recruiting CCSs from three pediatric oncology centers and using questionnaires to answer the study questions.

Results
To date, we have recruited 58 participants. The study is ongoing, and recruitment of participants will continue until January 2021.

Conclusions
The ACCS study will provide information on CCSs’ preferences and expectations for follow-up care and their transition into the adult setting. The results will help improve the LTFU care and cancer knowledge of CCSs and subsequently enhance adherence to follow-up care and reduce loss to follow-up in adulthood.

Trial Registration
ClinicalTrials.gov NCT04284189; https://clinicaltrials.gov/ct2/show/NCT04284189?id=NCT04284189

International Registered Report Identifier (IRRID)
PRR1-10.2196/18898
Evaluación del impacto ambiental de la construcción de una planta de tratamiento de aguas residuales. Caso río Pindo Chico, Puyo, Pastaza, Ecuador
Authors: Montero-Vega Fernando Steven , Molina-Cedeño Carla Stephany , Pillco-Herrera Briyidt Maryeli , Sarduy-Pereira Liliana Bárbara , Diéguez-Santana Karel 
Published: July 2020

El crecimiento de la población, la industrialización, las prácticas agrícolas y la urbanización aumentan la demanda de agua y, por lo tanto, la cantidad de aguas residuales generadas. El propósito de este documento es determinar los principales impactos ambientales de la construcción de la planta de tratamiento de aguas residuales del subsistema Pindo Chico en la ciudad del Puyo, Ecuador. Se recolectó información de línea base, mediante la implementación de listas de chequeo, y para la identificación y evaluación de impactos se confeccionó un diagrama de redes y se emplearon estructuras matriciales de doble entrada basadas en el sistema de Leopold original. Se analizaron siete actividades del proyecto y 12 componentes ambientales, y se determinaron 24 interacciones, de las cuales 11 fueron categorizadas como impactos ambientales significativos y dos muy significativos. El componente más afectado es la alteración del suelo, debido a la remoción de la cobertura vegetal, apertura de zanjas, creación de vías de acceso y construcción de la planta. Finalmente, se propusieron medidas correctivas en el plan de manejo ambiental para mitigar, prevenir y monitorear los impactos negativos que se generan.
Quality of Life and Level of Physical Activity In Students with and without Symptoms of Functional Dyspepsia and Irritable Bowel Syndrome Surveyed with Questionnaire “7×7” (7 Symptoms Per 7 Days)
Authors: Zhestkova T. V. 
Published: July 2020

Aim. Assessment of the quality of life and physical activity level in students with and without symptoms of functional dyspepsia (FD) and irritable bowel syndrome (IBS) according to questionnaire “7×7” (7 symptoms per 7 days).Materials and methods. Symptoms of FD and IBS were surveyed using the “7×7” questionnaire. Level of physical activity was evaluated according to the short IPAQ, and quality of life — to WAM questionnaires.Results. The study surveyed 92 students aged 20.7 ± 0.2 years (56 men and 36 women). We report borderline manifestations of functional disorders of the gastrointestinal tract (GIT) in 51.1 %, and FD and/or IBS symptoms of mild to moderate severity in 23.9 % of respondents. Symptoms of FD and/or IBS were equally common in men and women. Severity of FD and/or IBS symptoms was rated 4 [[3; 7] in men and 4 [[4; 11] in women (p = 0.25). Physical activity of 57.6 % in students corresponded to a moderate level. Healthy students were more likely to exhibit higher physical activity than individuals with FD and/or IBS symptoms, 56.5 and 31.9 %, respectively (p = 0.04). The level of wellbeing and severity of FD and/or IBS symptoms correlated negatively (r = –0.28, p = 0.01). Wellbeing and mood correlated directly with physical activity, r = 0.33, p = 0.001 and r = 0.27, respectively (p = 0.01).Conclusions. 1. Symptoms of FD and/or IBS occur widely among students and equally in men and women. Functional disorders of the gastrointestinal tract of mild to moderate severity occur in 23.9 % of students, with borderline symptoms registered with every second individual. 2. Healthy students significantly more often exhibited higher physical activity compared to individuals with FD and/or IBS symptoms of varying severity in the ratios of 56.5 and 31.9 % (p = 0.04). 3. Severity of FD and/or IBS in students negatively correlates with the wellbeing component of quality of life (r = –0.28, p = 0.01).
Endoscopic Biopsy in Differential Diagnosis of Colorectal Serrated Lesions
Authors: Khalin K. D. , Agapov M. Yu. , Zvereva L. V. , Stegniy K. V. 
Published: July 2020

Background.Preoperative biopsy is recommended for morphological verification of colorectal epithelial neoplasms prior to their endoscopic resection. However, histological reports for endoscopic biopsy and resected lesions are not reliably consistent.Aim.Assessment of sensitivity, specificity and accuracy of endoscopic biopsy in differential diagnosis of colorectal serrated adenomas and risk factors for variance between biopsy results and morphological examination of completely resected lesions.Materials and methods.The assay used data on 56 morphologically verified serrated adenomas diagnosed and resected in 50 patients (14 men, 36 women; average age 66.9 ± 10.5 years). Biopsy was taken from all tumours before endoscopic resection. Results of morphological examination of biopsy samples and resected tumours were analysed and compared. Sensitivity, specificity and accuracy of biopsy was assessed, with the tumour size and type and biopsy forceps system taken as criteria.Results.The identified cases included 22 (39.3%) right-colon, 21 (37.5%) left-colon and 13 (23.2%) rectal lesions of 28.5 ± 2.6 mm average size. Polypoid were 17 (30.3%), non-polypoid — 6 (10.7%) and spreading — 33 (59%) of the tumours. Full consistency of morphological examination was observed for 12 cases (21.4%). In 9 cases (16%), dysplasia was established as mild-graded with biopsy, whilst the eradicated tumours contained severe dysplastic foci. Foci of adenocarcinoma were detected in 10 tumours (including 2 with submucosal invasion), but only 2 cases were correctly diagnosed for malignant adenoma with biopsy. Tumour morphology was misidentified in 32 cases (57.1%).Conclusions.Preoperative forceps biopsy is shown to possess low sensitivity in differential diagnosis of serrated colorectal lesions and very low sensitivity to predict malignant serrated adenomas.
Avaliação dos conhecimentos para o tratamento não farmacológico da dor
Authors: Bonilla-Marciales Adriana Patricia , Vásquez-Hernández Skarlet Marcell , Ariza-Silva Pablo Andres , Pinzón-Gómez Ingrid Daniela , Ramos-Ortega Luyed , Santiago-Alvarez Jennifer Carolina , Arenas-Luna Gloria Ines , Jaimes-Valencia Mary Luz 
Published: July 2020

Las intervenciones para el alivio del dolor se clasifican en farmacológicas y no farmacológicas; las primeras incluyen la administración de fármacos analgésicos y las segundas utilizan terapias complementarias. El objetivo de este estudio fue diseñar y validar un instrumento de medición denominado “Conocimiento sobre intervenciones no farmacológicas para el alivio del dolor” para evaluar el nivel de conocimientos sobre intervenciones no farmacológicas para el manejo del dolor en un grupo de enfermeras profesionales y auxiliares de enfermería de una institución de salud de Bucaramanga, Colombia. Métodos: El instrumento se desarrolló en dos fases; la primera fase consistió en la búsqueda bibliográfica para el diseño, la validación facial y de contenido por expertos. En la segunda fase se evalúo la confiabilidad prueba- reprueba de la versión final del cuestionario. Resultados: La versión final del cuestionario contempla seis dimensiones propuestas por el Instituto Nacional de Medicina Alternativa de Estados Unidos con un total de 30 ítems. La confiabilidad de este instrumento fue baja (Índice Kappa-Cohen <0.60) en el 80% de los ítems. Conclusión: Este es el primer instrumento diseñado para medir los conocimientos sobre intervenciones no farmacológicas para el alivio del dolor en enfermeras y auxiliares de enfermería en nuestro país, sin embargo, se requiere continuar con procesos que permitan mejorar su confiabilidad y evaluar su validez.
Descripción clínico-epidemiológica de pacientes con enfermedad inflamatoria intestinal en una clínica de cuarto nivel en Cali
Authors: Rojas Rodríguez Carlos Arturo , Sánchez Londoño Santiago , Rojas Nelson , Sepúlveda Copete Mauricio , García Abadía Jairo Alberto , Jiménez Rivera Diego Fernando , Maldonado Gutiérrez Catalina , Tobón Guevara Angélica 
Published: July 2020

Introducción: en América Latina, la enfermedad inflamatoria intestinal (EII) es poco frecuente y la información, limitada. Se describieron características de los pacientes con EII en una unidad de gastroenterología de una clínica de alto nivel de atención en Cali, Colombia.
Materiales y métodos: estudio descriptivo de pacientes que consultaron con diagnóstico de enfermedad de Crohn (EC) o colitis ulcerativa (CU) a la Clínica Fundación Valle del Lili entre enero de 2011 y diciembre de 2015. Se realizó un análisis con Statistical Package for the Social Sciences de IBM (SPSS) versión 19, se calcularon la mediana y el rango intercuartílico para las variables numéricas, y frecuencias para las variables cualitativas.
Resultados: se incluyeron 416 participantes, 115 con EC y 301 con CU. El 41 % se clasificó como enfermedad leve, 23,5 % moderada y 35,3 % grave. Se realizó cirugía a 24 pacientes (9,0 %) con CU y 53 (46,1 %) con EC. En esta última, el manejo más frecuente fue los medicamentos biológicos (32,2 %), seguidos de inmunomoduladores (27,8 %), esteroides (20 %) y ácido 5-aminosalicílico (5-ASA) (11,3 %). El tratamiento más frecuente de CU fue 5-ASA (84,8 %), seguido de esteroides (32,19 %), azatioprina (24,6 %) y biológicos (15,9 %).
Conclusiones: el diagnóstico precoz sigue siendo un reto. La gravedad de la CU en los pacientes estudiados fue menor a la reportada en el mundo, lo cual no ocurrió con los pacientes con EC y podría estar en relación con el retraso diagnóstico. El uso de medicamentos biológicos se acercó a lo reportado en el primer mundo. Es difícil determinar si las menores tasas de cirugía se deben a una mejor respuesta clínica o a un difícil acceso a estas intervenciones.
Becoming a Narrative Researcher in Pakistan: Reflections from the Field
Authors: Khan Haji Karim 
Published: July 2020

<p><em>This reflective paper emerges from the reflections on my experience to carry out narrative studies in Pakistan —a country where narrative research in education is still very young. Field-notes, reflective journals and research memos were the key sources of triggering reflections on my learning to take the identity of a narrative researcher in a context where this approach is very young. </em></p><em>My reflections show the learning experience in conceptualising and practicing narrative studies in the country. The paper shows that I took the roles of an insider, co-constructor of stories, and trust-builder while taking up the identity of a narrative researcher in Pakistan. In addition, becoming a gender sensitive and knowing language and culture of the research participants enabled me to take up the role smoothly. Findings have pertinent implications for life history research studies in Pakistan and elsewhere.</em>
Superiors' Discretionary Allocations when Agents Face Disparate Performance Risk
Authors: Majerczyk Michael , Thomas Tyler F. 
Published: July 2020

ABSTRACT
Our study examines superiors' allocation decisions for otherwise homogeneous agents facing disparate performance risk (i.e., unequal likelihoods a given amount of effort will translate to an anticipated level of performance). We predict and find that superiors sympathize, through their bonus allocation decisions, with those agents confronted with greater performance risk. However, this behavior changes when superiors are responsible for allocating initial resources between the agents and have task-irrelevant reputational information concerning the agents, such that superiors favor the advantaged agent and give less sympathy to the disadvantaged agent. We provide additional evidence that such favoritism toward the advantaged agent leads to disparity in agents' fairness and satisfaction perceptions. Our results have implications for organizations, given the pervasiveness of discretion in allocation decisions and concerns for fairness, job satisfaction, and their effects on performance.
PARIWISATA DAN PENGEMBANGAN SUMBER DAYA MANUSIA
Authors: Parma I Putu Gede 
Published: July 2020

Abstrak Penelitian ini bertujuan untuk mengukur efektivitas dan memberikan rekomendasi implementasi SPMI pada sekolah model LPMP Bali dengan menggunakan model CIPP (context, input, process, product). Penelitian diawali dengan pengukuran tingkat kesesuaian antara hasil evaluasi awal sekolah model dengan capaian rapor mutu SNP sekolah model Tahun 2017. Hasil evaluasi awal pada 11 sekolah model binaan, menunjukkan bahwa tingkat kesesuaian capaian hasil evaluasi awal sekolah model SPMI Tahun 2018 dengan capain SNP dari rapor mutu sekolah model SPMI Provinsi Bali Tahun 2017 belum sebanding. Hal ini ditunjukkan oleh nilai korelasi yang tidak signifikan. Selanjutnya dari hasil tersebut dibuatkan strategi pendampingan yang tepat sesuai dengan kelemahan masing-masing sekolah dan dilaksanakan pendampingan selama 6 bulan terhadap sekolah model tersebut. Hasil evaluasi akhir setelah dilaksanakan pendampingan dibagi dalam lima kategori yaitu sangat efektif, efektif, cukup efektif, tidak efektif dan sangat tidak efektif. Evaluasi pada komponen konteks menunjukkan hasil yang efektif, pada komponen input hasilnya sangat efektif, sedangkan pada proses pemetaan, perencanaan mutu, dan pelaksanaan pemenuhan mutu efektif, monitoring dan evaluasi cukup efektif. Pada komponen hasil juga menunjukkan rata-rata capaian pada kategori efektif. Rekomendasi yang diberikan dari hasil penelitian ini adalah perlu dikembangkan strategi pendampingan yang sesuai dengan evaluasi awal masing-masing sekolah, serta perlu melaksanakan pengukuran hasil evaluasi akhir setelah diberikan pendampingan. Kata kunci: SPMI, sekolah model, konteks, input, proses, produk
PENGARUH PROFITABILITAS DAN LIKUIDITAS TERHADAP STRUKTUR MODAL PERUSAHAAN SEKTOR PROPERTY DAN REAL ESTATE DI BEI
Authors: Dewi Rosita , Suci Made , Mahardika AA. Ngurah Yudha Martin 
Published: July 2020

Abstrak Penelitian ini bertujuan untuk menguji pengaruh profitabilitas dan likuiditasterhadap struktur modal secara simultan maupun parsial. Desain penelitian yang digunakan adalah kuantitatif kausal dan sumber data yaitu data sekunder.Subjek penelitian ini adalah perusahaan sub sektor property dan real estate yang terdaftar di Bursa Efek Indonesia dan objek penelitian adalah profitabilitas, likuiditas dan struktur modal. Data dikumpulkan dengan teknik pencatatan dokumen.Sampel dalam penelitian ini yaitu data keuangan dari 18 perusahaan selama 2 tahun yang di dapat dengan teknik purposive sampling. Kemudian dianalisis dengan analisis regresilinier berganda menggunakan program SPSS 23 for windows. Hasil penelitian menunjukkan bahwa (1) profitabilitas dan likuiditas berpengaruh signifikanterhadap struktur modal dengan besar sumbangan pengaruh yaitu 92,5%, (2)profitabilitas berpengaruh negatif dan signifikanterhadap struktur modal sebesar38,2%, (3) likuiditas berpengaruh negatif dan signifikanterhadap struktur modal sebesar 6,7%. KataKunci: profitabilitas, likuiditas, struktur modal.
Las estrategias de lectura y su incidencia en la comprensión lectora de estudiantes de una universidad pública del noroeste de México
Authors: Espinosa Pulido Aidee 
Published: July 2020

Este trabajo presenta los resultados de una investigación que tuvo como objetivo indagar si es posible mejorar la comprensión lectora de los estudiantes de primer semestre de una institución pública del noroeste de México mediante estrategias de lectura. Se utilizó una metodología cuantitativa de carácter descriptiva. El tipo de diseño de investigación fue preexperimental con un solo grupo pretest y postest para la comprobación de la hipótesis planteada. El procedimiento fue evaluar con un pretest la comprensión lectora de los participantes para conocer el nivel en que se encontraban antes de la instrucción. Se continuó con la implementación de un taller de diez horas para instruir el uso de estrategias de lectura. Finalmente, se evaluó con un postest la comprensión lectora para comparar los resultados de ambos test y contar con elementos para determinar la efectividad o no de la intervención. Los resultados demostraron que después de la instrucción 38 % de los participantes avanzó de nivel y 50 % de los casos, aunque no logró cambiar de nivel, mejoró su comprensión lectora al obtener mayor puntaje. Por lo anterior, se recomienda la instrucción en el uso de estrategias y con ello favorecer la formación de lectores competentes.