bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collision-less shocks and solitons in dense laser-produced Fermi plasma
Authors: Goswami J. , Chandra S. , Sarkar J. , Chaudhuri S. , Ghosh B. 
Published: January 2020

AbstractThe theoretical investigation of shocks and solitary structures in a dense quantum plasma containing electrons at finite temperature, nondegenerate cold electrons, and stationary ions has been carried out. A linear dispersion relation is derived for the corresponding electron acoustic waves. The solitary structures of small nonlinearity have been studied by using the standard reductive perturbation method. We have considered collisions to be absent, and the shocks arise out of viscous force. Furthermore, with the help of a standard reductive perturbation technique, a KdV–Burger equation has been derived and analyzed numerically. Under limiting cases, we have also obtained the KdV solitary profiles and studied the parametric dependence. The results are important in explaining the many phenomena of the laser–plasma interaction of dense plasma showing quantum effects.
A novel fusion reactor with chain reactions for proton–boron11
Authors: Eliezer Shalom , Martinez-Val Jose M. 
Published: January 2020

AbstractUsing a combination of laser–plasma interactions and magnetic confinement configurations, a conceptual fusion reactor is proposed in this paper. Our reactor consists of the following: (1) A background plasma of boron11 and hydrogen ions, plus electrons, is generated and kept for a certain time, with densities of the order of a mg/cm3 and temperatures of tens of eV. Both the radiation level and the plasma thermal pressure are thus very low. (2) A plasma channel is induced in a solid target by irradiation with a high power laser that creates a very intense shock wave. This mechanism conveys the acceleration of protons in the laser direction. The mechanisms must be tuned for the protons to reach a kinetic energy of 300–1200 keV where the pB11 fusion cross section is significantly large (note that this value is not a temperature). (3) Those ultra-fast protons enter the background plasma and collide with boron11 to produce three alphas. Fusion born alphas collide with protons of the plasma and accelerate them causing a chain reaction. (4) A combination of an induction current and a magnetic bottle keeps the chain reaction process going on, for a pulse long enough to get a high energy gain. (5) Materials for the background plasma and the laser target must be replaced for starting a new chain reaction cycle.
City of culture, city of transformation: bringing together the urban past and urban present in The Hull Blitz Trail
Authors: Tomlinson Charlotte 
Published: January 2020

AbstractDuring World War II, Hull suffered from an intensity of bombing which made it one of the most heavily blitzed cities in Britain. Air raids fundamentally reshaped the history of the Yorkshire port city. In 2017, 75 years later, Hull's year as UK City of Culture marked another period of change and development. This article explores how one public history project, The Hull Blitz Trail, brought these two moments of urban transformation together, and reflects on some of the benefits and challenges of taking urban history beyond the academy. It outlines how public engagement projects can become more meaningful, more engaging and more ‘impactful’ if we carefully consider the physical and cultural landscape of the city today, as much as the histories themselves. However, combining the urban past and present influences our work in powerful ways, shaping the histories we are able to share, and how we share them.
Ready-to-eat cereal fortification: a modelling study on the impact of changing ready-to-eat cereal fortification levels on population intake of nutrients
Authors: Smith Jessica D , Jain Neha , Bailey Regan L 
Published: January 2020

AbstractObjective:Ready-to-eat (RTE) cereal is an important source of nutrients in the American diet. Recent regulatory changes to labelling requirements may impact the fortification of RTE cereal. We used an evidence-based approach to optimize the fortification of RTE cereal considering current dietary patterns and nutrition policy.Design:A US modelling study of cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) 2013–2014. The percentage of the population below the Estimated Average Requirement (EAR) and above the Upper Tolerable Intake Level (UL) was modelled under three scenarios: baseline, zero fortification and optimized fortification.Setting:USA.Participants:Toddlers aged 1–3 years, n 559; children aged 4–12 years, n 1540; adolescents aged 13–18 years, n 992; and adults aged ≥19 years, n 576.Results:Comparing current with optimized fortification, nutrient/100 g RTE cereal decreased for vitamin A, thiamin, riboflavin, niacin, vitamin B6, folic acid, vitamin B12, Ca and Fe (by 2–82 %). The amount of vitamins C and D increased (by 13 and 50 %, respectively). Among RTE cereal eaters, these changes resulted in modest increases in the percentage of the population aged ≥1 year below the EAR (+0·5 to +11·5 percentage points). Decreases were observed in the percentage of the population above the UL.Conclusions:Fortification of RTE cereal can be optimized to provide key nutrients and minimize the percentage of the population below the EAR and above the UL. Dietary intake modelling is useful to ensure that RTE cereal continues to help the population meet their nutrient needs.
Primer for a New World
Authors: Vincke Estefanía Yunes 
Published: January 2020

AbstractThe Cartilla para enseñar a leer (1569), attributed to Flemish Franciscan Pedro de Gante, was one of the most important primers from the early years of the viceroyalty of New Spain. Nevertheless, the primer's importance during the process of cultural contact has been largely ignored. As did other primers of the period, the Cartilla contained the most important prayers, but what sets the Cartilla aside is that its selection of prayers is presented in a trilingual version, in Castilian, Latin, and Nahuatl. The content of the Cartilla invites the question as to why Gante, a missionary focused on writing doctrinal works in Nahuatl, would compose a primer that is trilingual, but raises another that is perhaps more perplexing: Why were most of the prayers in Castilian? In this article, I intend to shed a light on Gante's decision to create a complex tool that could be employed by a mixed audience of Castilian, creole, mestizo and Nahua children. By doing this, Gante unwittingly started a process of cultural contact in which language played a pivotal role. The Cartilla thus presents itself as a multifaceted tool that helped shaped the culture of the Basin of Mexico during the early years of the viceroyalty.
miR-130a and Tgfβ Content in Extracellular Vesicles Derived from the Serum of Subjects at High Cardiovascular Risk Predicts their In-Vivo Angiogenic Potential
Authors: Cavallari Claudia , Figliolini Federico , Tapparo Marta , Cedrino Massimo , Trevisan Alessandra , Positello Lorenza , Rispoli Pietro , Solini Anna , Migliaretti Giuseppe , Camussi Giovanni , Brizzi Maria Felice 
Published: January 2020

AbstractSerum-derived extracellular vesicles (sEV) from healthy donors displayin-vivopro-angiogenic properties. To identify patients that may benefit from autologous sEV administration for pro-angiogenic purposes, sEV angiogenic capability has been evaluated in type 2 diabetic (T2DM) subjects (D), in obese individuals with (OD) and without (O) T2DM, and in subjects with ischemic disease (IC) (9 patients/group). sEV display different angiogenic properties in such cluster of individuals. miRNomic profile and TGFβ content in sEV were evaluated. We found that miR-130a and TGFβ content correlates with sEVin-vitroandin-vivoangiogenic properties, particularly in T2DM patients. Ingenuity Pathway Analysis (IPA) identified a number of genes as among the most significant miR-130a interactors. Gain-of-function experiments recognized homeoboxA5 (HOXA5) as a miR-130a specific target. Finally, ROC curve analyses revealed that sEV ineffectiveness could be predicted (Likelihood Ratio+ (LH+) = 3.3 IC 95% from 2.6 to 3.9) by comparing miR-130a and TGFβ content ‘in Series’. We demonstrate that sEV from high cardiovascular risk patients have different angiogenic properties and that miR-130a and TGFβ sEV content predicts ‘true ineffective sEVs’. These results provide the rationale for the use of these assays to identify patients that may benefit from autologous sEV administration to boost the angiogenetic process.
Pro-inflammatory macrophages coupled with glycolysis remodel adipose vasculature by producing platelet-derived growth factor-B in obesity
Authors: Onogi Yasuhiro , Wada Tsutomu , Okekawa Akira , Matsuzawa Takatoshi , Watanabe Eri , Ikeda Keisuke , Nakano Minoru , Kitada Munehiro , Koya Daisuke , Tsuneki Hiroshi , Sasaoka Toshiyasu 
Published: January 2020

AbstractAdipose tissue macrophages (ATMs) play a central role in tissue remodeling and homeostasis. However, whether ATMs promote adipose angiogenesis in obesity remains unclear. We examined the impact of ATMs deletion on adipose angiogenesis and tissue expansion in the epididymal white adipose tissue (eWAT) of high-fat diet (HFD)-fed mice by using liposome-encapsulated clodronate. We further elucidated the induction mechanisms of platelet-derived growth factor (PDGF)-B in macrophages in response to obesity-associated metabolic stresses, since it plays a significant role in the regulation of pericyte behavior for the initiation of neoangiogenesis during tissue expansion. ATM depletion prevented adipose tissue expansion in HFD-fed mice by inhibiting pericyte detachment from vessels, resulting in less vasculature in eWAT. The lipopolysaccharide (LPS) stimulation and high glucose concentration augmented glucose incorporation and glycolytic capacity with the induction of Pdgfb mRNA. This effect was mediated through extracellular signal-regulated kinase (ERK) among mitogen-activated protein kinases coupled with glycolysis in RAW264.7 macrophages. The Pdgfb induction system was distinct from that of inflammatory cytokines mediated by mechanistic target of rapamycin complex 1 (mTORC1) and NFκB signaling. Thus, obesity-associated hyperglycemia and chronic inflammation fuels ERK signaling coupled with glycolysis in pro-inflammatory macrophages, which contribute to the expansion of eWAT through PDGF-B-dependent vascular remodeling.
Syntaxin-3 is dispensable for basal neurotransmission and synaptic plasticity in postsynaptic hippocampal CA1 neurons
Authors: Shi Shan , Ma Ke , Bin Na-Ryum , Harada Hidekiyo , Xie Xiaoyu , Huang Mengjia , Liu Haiyu , Lee Soomin , Wang Xue Fan , Adachi Roberto , Monnier Philippe P. , Zhang Liang , Sugita Shuzo 
Published: January 2020

AbstractRecent evidence suggests that SNARE fusion machinery play critical roles in postsynaptic neurotransmitter receptor trafficking, which is essential for synaptic plasticity. However, the key SNAREs involved remain highly controversial; syntaxin-3 and syntaxin-4 are leading candidates for the syntaxin isoform underlying postsynaptic plasticity. In a previous study, we showed that pyramidal-neuron specific conditional knockout (cKO) of syntaxin-4 significantly reduces basal transmission, synaptic plasticity and impairs postsynaptic receptor trafficking. However, this does not exclude a role for syntaxin-3 in such processes. Here, we generated and analyzed syntaxin-3 cKO mice. Extracellular field recordings in hippocampal slices showed that syntaxin-3 cKO did not exhibit significant changes in CA1 basal neurotransmission or in paired-pulse ratios. Importantly, there were no observed differences during LTP in comparison to control mice. Syntaxin-3 cKO mice performed similarly as the controls in spatial and contextual learning tasks. Consistent with the minimal effects of syntaxin-3 cKO, syntaxin-3 mRNA level was very low in hippocampal and cortex pyramidal neurons, but strongly expressed in the corpus callosum and caudate axon fibers. Together, our data suggest that syntaxin-3 is dispensable for hippocampal basal neurotransmission and synaptic plasticity, and further supports the notion that syntaxin-4 is the major isoform mediating these processes.
Temperature distribution in driven granular mixtures does not depend on mechanism of energy dissipation
Authors: Bodrova Anna S. , Osinsky Alexander , Brilliantov Nikolai V. 
Published: January 2020

AbstractWe study analytically and numerically the distribution of granular temperatures in granular mixtures for different dissipation mechanisms of inelastic inter-particle collisions. Both driven and force-free systems are analyzed. We demonstrate that the simplified model of a constant restitution coefficient fails to predict even qualitatively a granular temperature distribution in a homogeneous cooling state. At the same time we reveal for driven systems a stunning result – the distribution of temperatures in granular mixtures is universal. That is, it does not depend on a particular dissipation mechanism of inter-particles collisions, provided the size distributions of particles is steep enough. The results of the analytic theory are compared with simulation results obtained by the direct simulation Monte Carlo (DSMC). The agreement between the theory and simulations is perfect. The reported results may have important consequences for fundamental science as well as for numerous application, e.g. for the experimental modelling in a lab of natural processes.
Oropharyngeal microbiome of a college population following a meningococcal disease outbreak
Authors: Retchless Adam C. , Kretz Cécilia B. , Rodriguez-Rivera Lorraine D. , Chen Alexander , Soeters Heidi M. , Whaley Melissa J. , Wang Xin 
Published: January 2020

AbstractAsymptomatic oropharyngeal carriage ofNeisseria meningitidispeaks in adolescence and young adulthood. Following a meningococcal disease outbreak at a U.S. college, we profiled the oropharyngeal microbiomes of 158 students to identify associations between bacterial community composition and meningococcal carriage or risk factors for carriage, including male gender, smoking, and frequent social mixing. Metagenomic shotgun sequencing identified 268 bacterial taxa at the genus or species level, withStreptococcus, Veillonella, andRothiaspecies being most abundant. Microbiome composition showed weak associations with meningococcal carriage and risk factors for carriage.N. meningitidisabundance was positively correlated with that ofFusobacterium nucleatum, consistent with hypothesized propionic acid cross-feeding. Additional species had positive abundance correlations withN. meningitidis, includingAggregatibacter aphrophilus,Campylobacter rectus,Catonella morbi,Haemophilus haemolyticus, andParvimonas micra.N. meningitidisabundance was negatively correlated with unidentifiedVeillonellaspecies. Several of these species are commonly found in dental plaque, whileN. meningitidisis primarily found in the pharynx, suggesting that ecological interactions extend throughout the oral cavity. Although risk factors for meningococcal carriage do not strongly impact most bacterial species in the oropharynx, variation in the upper respiratory tract microbiome may create conditions that are more or less favorable forN. meningitidiscarriage.
Radiation-induced alterations in immunogenicity of a murine pancreatic ductal adenocarcinoma cell line
Authors: Schröter Philipp , Hartmann Laura , Osen Wolfram , Baumann Daniel , Offringa Rienk , Eisel David , Debus Jürgen , Eichmüller Stefan B. , Rieken Stefan 
Published: January 2020

AbstractPancreatic ductal adenocarcinoma (PDA) is highlighted by resistance to radiotherapy with the possible exception of hypofractionated irradiation. As single photon doses were reported to increase immunogenicity, we investigated dose-dependent irradiation effects on clonogenic survival, expression of immunologically relevant cell surface molecules and susceptibility to cytotoxic T cell (CTL) mediated killing using a murine PDA cell line. Clonogenicity decreased in a dose-responsive manner showing enhanced radioresistance at single photon doses below 5 Gy. Cell cycle analysis revealed a predominant G2/M arrest, being most pronounced 12 h after irradiation. Polyploidy increased in a dose- and time-dependent manner reaching a maximum frequency 60 h following irradiation with 10 Gy. Irradiation increased surface expression of MHC class I molecules and of immunological checkpoint molecules PDL-1 and CD73, especially at doses ≥ 5 Gy, but not of MHC class II molecules and CXCR4 receptors. Cytotoxicity assays revealed increased CTL lysis of PDA cells at doses ≥ 5 Gy. For the PDA cell line investigated, our data show for the first time that single photon doses ≥ 5 Gy effectively inhibit colony formation and induce a G2/M cell cycle arrest. Furthermore, expression levels of immunomodulatory cell surface molecules became altered possibly enhancing the susceptibility of tumour cells to CTL lysis.
Characterizing the microbiomes of Antarctic sponges: a functional metagenomic approach
Authors: Moreno-Pino Mario , Cristi Antonia , Gillooly James F. , Trefault Nicole 
Published: January 2020

AbstractRelatively little is known about the role of sponge microbiomes in the Antarctic marine environment, where sponges may dominate the benthic landscape. Specifically, we understand little about how taxonomic and functional diversity contributes to the symbiotic lifestyle and aids in nutrient cycling. Here we use functional metagenomics to investigate the community composition and metabolic potential of microbiomes from two abundant Antarctic sponges, Leucetta antarctica and Myxilla sp. Genomic and taxonomic analyses show that both sponges harbor a distinct microbial community with high fungal abundance, which differs from the surrounding seawater. Functional analyses reveal both sponge-associated microbial communities are enriched in functions related to the symbiotic lifestyle (e.g., CRISPR system, Eukaryotic-like proteins, and transposases), and in functions important for nutrient cycling. Both sponge microbiomes possessed genes necessary to perform processes important to nitrogen cycling (i.e., ammonia oxidation, nitrite oxidation, and denitrification), and carbon fixation. The latter indicates that Antarctic sponge microorganisms prefer light-independent pathways for CO2 fixation mediated by chemoautotrophic microorganisms. Together, these results show how the unique metabolic potential of two Antarctic sponge microbiomes help these sponge holobionts survive in these inhospitable environments, and contribute to major nutrient cycles of these ecosystems.
Transcriptome analysis of fibroblasts from schizophrenia patients reveals differential expression of schizophrenia-related genes
Authors: Etemadikhah Mitra , Niazi Adnan , Wetterberg Lennart , Feuk Lars 
Published: January 2020

AbstractSchizophrenia is a complex neurodevelopmental disorder with high rate of morbidity and mortality. While the heritability rate is high, the precise etiology is still unknown. Although schizophrenia is a central nervous system disorder, studies using peripheral tissues have also been established to search for patient specific biomarkers and to increase understanding of schizophrenia etiology. Among all peripheral tissues, fibroblasts stand out as they are easy to obtain and culture. Furthermore, they keep genetic stability for long period and exhibit molecular similarities to cells from nervous system. Using a unique set of fibroblast samples from a genetically isolated population in northern Sweden, we performed whole transcriptome sequencing to compare differentially expressed genes in seven controls and nine patients. We found differential fibroblast expression between cases and controls for 48 genes, including eight genes previously implicated in schizophrenia or schizophrenia related pathways; HGF, PRRT2, EGR1, EGR3, C11orf87, TLR3, PLEKHH2 and PIK3CD. Weighted gene correlation network analysis identified three differentially co-expressed networks of genes significantly-associated with schizophrenia. All three modules were significantly suppressed in patients compared to control, with one module highly enriched in genes involved in synaptic plasticity, behavior and synaptic transmission. In conclusion, our results support the use of fibroblasts for identification of differentially expressed genes in schizophrenia and highlight dysregulation of synaptic networks as an important mechanism in schizophrenia.
Sea-Island-Like Morphology of CuNi Bimetallic Nanoparticles Uniformly Anchored on Single Layer Graphene Oxide as a Highly Efficient and Noble-Metal-Free Catalyst for Cyanation of Aryl Halides
Authors: Mayakrishnan Gopiraman , Elayappan Vijayakumar , Kim Ick Soo , Chung Ill-Min 
Published: January 2020

AbstractAryl nitriles are versatile compounds that can be synthesized via transition-metal-mediated cyanation of aryl halides. Most of the supported-heterogeneous catalysts are noble-metals based and there are very limited numbers of efficient non-noble metal based catalysts demonstrated for the cyanation of aryl halides. Herein, bimetallic CuNi-oxide nanoparticles supported graphene oxide nanocatalyst (CuNi/GO-I and CuNi/GO-II) has been demonstrated as highly efficient system for the cyanation of aryl halides with K4[Fe(CN)6] as a cyanating agent. Metal-support interaction, defect ratio and synergistic effect with the bimetallic nanocatalyst were investigated. To our delight, the CuNi/GO-I system activity transformed a wide range of substrates such as aryl iodides, aryl bromides, aryl chlorides and heteroaryl compounds (Yields: 95–71%, TON/TOF: 50–38/2 h−1). Moreover, enhanced catalytic performance of CuNi/GO-I and CuNi/GO-II in reduction of 4-nitropehnol with NaBH4 was also confirmed (kapp = 18.2 × 10−3 s−1 with 0.1 mg of CuNi/GO-I). Possible mechanism has been proposed for the CuNi/GO-I catalyzed cyanation and reduction reactions. Reusability, heterogeneity and stability of the CuNi/GO-I are also found to be good.
Signalling architectures can prevent cancer evolution
Authors: Oña Leonardo , Lachmann Michael 
Published: January 2020

AbstractCooperation between cells in multicellular organisms is preserved by an active regulation of growth through the control of cell division. Molecular signals used by cells for tissue growth are usually present during developmental stages, angiogenesis, wound healing and other processes. In this context, the use of molecular signals triggering cell division is a puzzle, because any molecule inducing and aiding growth can be exploited by a cancer cell, disrupting cellular cooperation. A significant difference is that normal cells in a multicellular organism have evolved in competition between high-level organisms to be altruistic, being able to send signals even if it is to their detriment. Conversely, cancer cells evolve their abuse over the cancer’s lifespan by out-competing their neighbours. A successful mutation leading to cancer must evolve to be adaptive, enabling a cancer cell to send a signal that results in higher chances to be selected. Using a mathematical model of such molecular signalling mechanism, this paper argues that a signal mechanism would be effective against abuse by cancer if it affects the cell that generates the signal as well as neighbouring cells that would receive a benefit without any cost, resulting in a selective disadvantage for a cancer signalling cell. We find that such molecular signalling mechanisms normally operate in cells as exemplified by growth factors. In scenarios of global and local competition between cells, we calculate how this process affects the fixation probability of a mutant cell generating such a signal, and find that this process can play a key role in limiting the emergence of cancer.