bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asymptotic analysis of internal relaxation oscillations in a conceptual climate model
Authors: Płociniczak Łukasz 
Published: March 2020

Abstract
We construct a dynamical system based on the Källén–Crafoord–Ghil conceptual climate model which includes the ice–albedo and precipitation–temperature feedbacks. Further, we classify the stability of various critical points of the system and identify a parameter which change generates a Hopf bifurcation. This gives rise to a stable limit cycle around a physically interesting critical point. Moreover, it follows from the general theory that the periodic orbit exhibits relaxation-oscillations that are a characteristic feature of the Pleistocene ice ages. We provide an asymptotic analysis of their behaviour and derive a formula for the period along with several estimates. They, in turn, are in a decent agreement with paleoclimatic data and are independent of any parametrization used. Whence, our simple but robust model shows that a climate may exhibit internal relaxation oscillations without any external forcing and for a wide range of parameters.
Littlewood’s Problem for Sets with Multidimensional Structure
Authors: Hanson Brandon 
Published: March 2020

Abstract
We give $L^1$-norm estimates for exponential sums of a finite sets $A$ consisting of integers or lattice points. Under the assumption that $A$ possesses sufficient multidimensional structure, our estimates are stronger than those of McGehee–Pigno–Smith and Konyagin. These theorems improve upon past work of Petridis.
A Randomized Dose-Escalating Phase I Trial of a Replication-Deficient Lymphocytic Choriomeningitis Virus Vector-Based Vaccine Against Human Cytomegalovirus
Authors: Schwendinger Michael , Thiry Georges , De Vos Beatrice , Leroux-Roels Geert , Bruhwyler Jacques , Huygens Ariane , Ganeff Corinne , Buchinger Heidemarie , Orlinger Klaus K , Pinschewer Daniel D , Monath Thomas P , Lilja Anders E 
Published: March 2020

Abstract

Background
A vaccine (HB-101) consisting of 2 nonreplicating lymphocytic choriomeningitis virus (LCMV) vectors expressing the human cytomegalovirus antigens glycoprotein B (gB) and the 65-kD phosphoprotein (pp65), respectively, is in development to prevent cytomegalovirus infection.

Methods
HB-101 was tested in cytomegalovirus-naive, healthy adults in a randomized, double-blind, placebo-controlled, dose-escalation Phase I trial. Fifty-four subjects received low, medium, or high dose of HB-101 or placebo by intramuscular administration at Month 0, 1, and 3. Safety and immunogenicity were the respective primary and secondary endpoints. Subjects were followed for 12 months after the initial immunization.

Results
Vaccination was associated with transient mild to moderate adverse events. HB-101 administration induced dose-dependent gB- and pp65-specific cellular responses, dominated by pp65-specific CD8 T cells, a high fraction of which were polyfunctional. Two administrations were sufficient to elicit dose-dependent gB-binding and cytomegalovirus-neutralizing antibodies (Abs). Cytomegalovirus-specific immune responses were boosted after each administration. Only 1 of 42 vaccine recipients mounted a transient LCMV vector-neutralizing Ab response.

Conclusions
HB-101 was well tolerated and induced cytomegalovirus-specific polyfunctional CD8 T-cell and neutralizing Ab responses in the majority of subjects. Lack of vector-neutralizing Ab responses should facilitate booster vaccinations. These results justify further clinical evaluation of this vaccine candidate.
Human brain microvascular endothelial cell pairs model tissue-level blood–brain barrier function
Authors: O’Connor Blakely B , Grevesse Thomas , Zimmerman John F , Ardoña Herdeline Ann M , Jimenez Jorge A , Bitounis Dimitrios , Demokritou Philip , Parker Kevin Kit 
Published: March 2020

AbstractThe blood–brain barrier plays a critical role in delivering oxygen and nutrients to the brain while preventing the transport of neurotoxins. Predicting the ability of potential therapeutics and neurotoxicants to modulate brain barrier function remains a challenge due to limited spatial resolution and geometric constraints offered by existing in vitro models. Using soft lithography to control the shape of microvascular tissues, we predicted blood–brain barrier permeability states based on structural changes in human brain endothelial cells. We quantified morphological differences in nuclear, junction, and cytoskeletal proteins that influence, or indicate, barrier permeability. We established a correlation between brain endothelial cell pair structure and permeability by treating cell pairs and tissues with known cytoskeleton-modulating agents, including a Rho activator, a Rho inhibitor, and a cyclic adenosine monophosphate analog. Using this approach, we found that high-permeability cell pairs showed nuclear elongation, loss of junction proteins, and increased actin stress fiber formation, which were indicative of increased contractility. We measured traction forces generated by high- and low-permeability pairs, finding that higher stress at the intercellular junction contributes to barrier leakiness. We further tested the applicability of this platform to predict modulations in brain endothelial permeability by exposing cell pairs to engineered nanomaterials, including gold, silver–silica, and cerium oxide nanoparticles, thereby uncovering new insights into the mechanism of nanoparticle-mediated barrier disruption. Overall, we confirm the utility of this platform to assess the multiscale impact of pharmacological agents or environmental toxicants on blood–brain barrier integrity.
Unfolding the Past, Proving the Present: Social Media Evidence in Terrorism Finance Court Cases
Authors: Anwar Tasniem 
Published: March 2020

AbstractDuring terrorism trials, social media activities such as tweeting, Facebook posts, and WhatsApp conversations have become an essential part of the evidence presented. Amidst the complexity of prosecuting crimes with limited possibilities for criminal investigations and evidence collection, social media interactions can provide valuable information to reconstruct events that occurred there-and-then, to prosecute in the here-and-now. This paper follows social media objects as evidentiary objects in different court judgments to research how security practices and knowledge interact with legal practices in the court room. I build on the notion of the folding object as described by Bruno Latour and Amade M'charek to research the practices and arguments of the judges through which they unfold some of the histories, interpretations, and politics inside the object as reliable evidence. This concept allows for an in-depth examination of how histories are entangled in the presentation of an evidentiary object and how these references to histories are made (in)visible during legal discussions on security and terrorism. The paper therefore contributes to the field of critical security studies by focusing on how security practices are mediated in the everyday legal settings of domestic court rooms.
Salmonella Contamination of Seafood in Landing Centers and Retail Markets of Mumbai, India
Authors: Prabhakar Parmanand , Lekshmi Manjusha , Ammini Parvathi , Nayak Binaya Bhusan , Kumar Sanath 
Published: March 2020

Abstract

Background
Seafood contamination with Salmonella enterica is not only a public health concern, but can also lead to economic losses due to import rejections. Continuous monitoring of seafood for Salmonella is necessary for risk assessment and to establish suitable control measures.

Objective
The objective of this study was to determine the extent of Salmonella contamination of seafood in fish landing centers and retails markets.

Methods
In this study, we analyzed seafood samples from three fish landing centers and seven retail markets of Mumbai, India for S. enterica contamination. Salmonella was isolated using multiple selective enrichment broths and selective agars, and identified by conventional biochemical tests followed by polymerase chain reaction (PCR).

Results
Of 82 samples of seafood, comprising both finfish and shellfish, Salmonella was detected in 17 (20.7%) finfish samples. None of the shellfish samples (shrimps, clams, and cephalopods) were found to be contaminated with Salmonella. Samples from both landing centers and fish markets, as well as from pelagic and demersal sources, harbored Salmonella. Source-wise analysis showed that 11 of 57 (19.3%) samples from retail fish markets and 6 of 25 (24%) samples from fish landing centers were contaminated with Salmonella.

Conclusions
The study emphasizes the need to implement measures to prevent anthropogenic contamination of coastal waters and improve the hygiene of retail fish markets in Mumbai.

Highlights
Seafood from landing centers and retail markets, as well as from pelagic and demersalhabitats were similarly contaminated with Salmonella. Fish species widely consumed in the region of this study were found highly contaminated with Salmonella.
Printeos v Commission: Importance Of Equal Treatment And Duty To State Reasons In The Calculation Of Fines On Mono-Product Undertakings
Authors: Lourenço Nuno Calaim 
Published: March 2020

Abstract
The General Court (GC), dismissing an appeal from Printeos, held that the application of a non-linear methodology in calculating the amount of fines for different mono-product cartel participants does not, in principle, give rise to a breach of the right to equal treatment and that, by re-imposing a fine on Printeos, the Commission did not breach its right not to be tried twice for the same infringement (the ne bis in idem principle).
Investigating the role of environment in pika (Ochotona) body size patterns across taxonomic levels, space, and time
Authors: Westover Marie L , Smith Felisa A 
Published: March 2020

AbstractBody size is an important trait in animals because it influences a multitude of additional life history traits. The causal mechanisms underlying body size patterns across spatial, temporal, and taxonomic hierarchies are debated, and of renewed interest in this era of climate change. Here, we tested multiple hypotheses regarding body mass patterns at the intraspecific and interspecific levels. We investigated body size patterns within a climate-sensitive small mammal species, Ochotona princeps (n = 2,873 individuals), across their range with local environmental variables. We also examined body mass of populations over time to determine if body size has evolved in situ in response to environmental change. At the interspecific level we compared the mean mass of 26 pika species (genus Ochotona) to determine if environmental temperatures, food availability, habitat variability, or range area influence body size. We found correlations between temperature, vegetation, and particularly precipitation variables, with body mass within O. princeps, but no linear relationship between body size and any climate or habitat variable for Ochotona species. Body size trends in relation to climate were stronger at the intraspecific than the interspecific level. Our results suggest that body size within O. princeps likely is related to food availability, and that body size evolution is not always a viable response to temperature change. Different mechanisms may be driving body size at the interspecific and intraspecific levels and factors other than environment, such as biotic interactions, may also be influential in determining body size over space and time.
Soil nitrogen availability intensifies negative density-dependent effects in a subtropical forest
Authors: Huang Fengmin , Liang Minxia , Zheng Yi , Liu Xubing , Chen Yuxin , Li Wenbin , Luo Shan , Yu Shixiao 
Published: March 2020

Abstract

Aims
The importance of density-dependent mortality in maintaining tree species diversity is widely accepted. However, density-dependent effects may vary in magnitude and direction with different abiotic conditions in forests. Theoretical predictions surmise that density-dependent effects may vary with soil available nitrogen (AN), but this still needs to be tested.

Methods
We analyzed the density-dependent effects on survival of newly germinated seedlings for 18 common species based on a long-term seedling census across environmental gradients in a subtropical forest. We also conducted a root lesion detection experiment for five species to investigate the potential effects of pathogens on variation in density-dependent disease between rich and poor AN environments.

Important Findings
The seedling dynamics analysis revealed that the strength of density-dependent effects increased with AN, shifting from neutral or positive with low AN to negative with high AN. Three of the five tree species had stronger density-dependent effects on root lesions in rich AN environments than in poor AN environments, which is consistent with the results of a long-term seedling dynamics analysis. We also found higher species diversity in rich AN environments, which may be promoted by the stronger negative density-dependent effects. Both the seedling dynamic analysis and root lesion detection experiment revealed stronger negative density-dependent effects in higher AN environment, resulting from stronger disease pressure by soil pathogens. Our study emphasized the importance of considering context dependence when testing the density dependence hypotheses.
Slower development of lower canopy beans produces better coffee
Authors: Cheng Bing , Smyth Heather E , Furtado Agnelo , Henry Robert J 
Published: March 2020

Abstract
The production of high-quality coffee is being challenged by changing climates in coffee-growing regions. The coffee beans from the upper and lower canopy at different development stages of the same plants were analyzed to investigate the impact of the microenvironment on gene expression and coffee quality. Compared with coffee beans from the upper canopy, lower canopy beans displayed more intense aroma with higher caffeine, trigonelline, and sucrose contents, associated with greater gene expression in the representative metabolic pathways. Global gene expression indicated a longer ripening in the lower canopy, resulting from higher expression of genes relating to growth inhibition and suppression of chlorophyll degradation during early bean ripening. Selection of genotypes or environments that enhance expression of the genes slowing bean development may produce higher quality coffee beans, allowing coffee production in a broader range of available future environments.
SuperCLASS – I. The super cluster assisted shear survey: Project overview and data release 1
Authors: Battye Richard A , Brown Michael L , Casey Caitlin M , Harrison Ian , Jackson Neal J , Smail Ian , Watson Robert A , Hales Christopher A , Manning Sinclaire M , Hung Chao-Ling , Riseley Christopher J , Abdalla Filipe B , Birkinshaw Mark , Demetroullas Constantinos , Chapman Scott , Beswick Robert J , Muxlow Tom W B , Bonaldi Anna , Camera Stefano , Hillier Tom , Kay Scott T , Peters Aaron , Sanders David B , Thomas Daniel B , Thomson A P , Tunbridge Ben , Whittaker Lee ,   (SuperCLASS Collaboration)
Published: March 2020

ABSTRACT
The SuperCLuster Assisted Shear Survey (SuperCLASS) is a legacy programme using the e-MERLIN interferometric array. The aim is to observe the sky at L-band (1.4 GHz) to a r.m.s. of $7\, \mu {\rm Jy}\,$beam−1 over an area of $\sim 1\, {\rm deg}^2$ centred on the Abell 981 supercluster. The main scientific objectives of the project are: (i) to detect the effects of weak lensing in the radio in preparation for similar measurements with the Square Kilometre Array (SKA); (ii) an extinction free census of star formation and AGN activity out to z ∼ 1. In this paper we give an overview of the project including the science goals and multiwavelength coverage before presenting the first data release. We have analysed around 400 h of e-MERLIN data allowing us to create a Data Release 1 (DR1) mosaic of $\sim 0.26\, {\rm deg}^2$ to the full depth. These observations have been supplemented with complementary radio observations from the Karl G. Jansky Very Large Array (VLA) and optical/near infrared observations taken with the Subaru, Canada-France-Hawaii, and Spitzer Telescopes. The main data product is a catalogue of 887 sources detected by the VLA, of which 395 are detected by e-MERLIN and 197 of these are resolved. We have investigated the size, flux, and spectral index properties of these sources finding them compatible with previous studies. Preliminary photometric redshifts, and an assessment of galaxy shapes measured in the radio data, combined with a radio-optical cross-correlation technique probing cosmic shear in a supercluster environment, are presented in companion papers.
Earth-size planet formation in the habitable zone of circumbinary stars
Authors: Barbosa G O , Winter O C , Amarante A , Izidoro A , Domingos R C , Macau E E N 
Published: March 2020

ABSTRACT
This work investigates the possibility of close binary (CB) star systems having Earth-size planets within their habitable zones (HZs). First, we selected all known CB systems with confirmed planets (totaling 22 systems) to calculate the boundaries of their respective HZs. However, only eight systems had all the data necessary for the computation of HZ. Then, we numerically explored the stability within HZs for each one of the eight systems using test particles. From the results, we selected five systems that have stable regions inside HZs, namely Kepler-34,35,38,413, and 453. For these five cases of systems with stable regions in HZ, we perform a series of numerical simulations for planet formation considering discs composed of planetary embryos and planetesimals, with two distinct density profiles, in addition to the stars and host planets of each system. We found that in the case of the Kepler-34 and 453 systems, no Earth-size planet is formed within HZs. Although planets with Earth-like masses were formed in Kepler-453, they were outside HZ. In contrast, for the Kepler-35 and 38 systems, the results showed that potentially habitable planets are formed in all simulations. In the case of the Kepler-413system, in just one simulation, a terrestrial planet was formed within HZ.
Mid-infrared variability of γ-ray emitting blazars
Authors: Anjum Ayesha , Stalin C S , Rakshit Suvendu , Gudennavar Shivappa B , Durgapal Alok 
Published: March 2020

ABSTRACT
Using data from the Wide-field Infrared Survey Explorer, we studied the mid-infrared (mid-IR) 3.4 μm (W1-band) and 4.6 μm (W2-band) flux variability of γ-ray emitting blazars. Our sample consists of 460 flat spectrum radio quasars (FSRQs) and 575 BL Lacertae (BL Lac) objects. On intraday time-scales, the median amplitude of variability (σm) for FSRQs is 0.04$^{+0.03}_{-0.02}$ and 0.05$^{+0.03}_{-0.02}$ mag in W1 and W2 bands. For BL Lacs, we found median σm in W1(W2) bands of 0.04$^{+0.01}_{-0.02}$ (0.04$^{+0.02}_{-0.02}$) mag. On long time-scales, for FSRQs we found a median σm of 0.44$^{+0.28}_{-0.27}$ and 0.45$^{+0.27}_{-0.27}$ mag in W1 and W2 bands, while for BL Lacs, the median values are 0.21$^{+0.18}_{-0.12}$ and 0.22$^{+0.18}_{-0.11}$ mag in W1 and W2 bands. From statistical tests, we found FSRQs to show larger σm than BL Lacs on both intraday and long time-scales. Among blazars, low synchrotron peaked sources showed larger σm compared to intermediate synchrotron peaked and high synchrotron peaked sources. The larger σm seen in FSRQs relative to BL Lacs on both intraday and long time-scales could be due to them having the most powerful relativistic jets and/or their mid-IR band coinciding with the peak of the electron energy distribution. BL Lacs have low power jets and the observational window too traces the emission from low-energy electrons, thereby leading to low σm. In both FSRQs and BL Lacs predominantly a bluer when brighter behaviour was observed. No correlation is found between σm and black hole mass.
Constraining properties of neutron star merger outflows with radio observations
Authors: Dobie Dougal , Kaplan David L , Hotokezaka Kenta , Murphy Tara , Deller Adam , Hallinan Gregg , Nissanke Samaya 
Published: March 2020

ABSTRACT
The jet opening angle and inclination of GW170817 – the first detected binary neutron star merger – were vital to understand its energetics, relation to short gamma-ray bursts, and refinement of the standard siren-based determination of the Hubble constant, H0. These basic quantities were determined through a combination of the radio light curve and Very Long Baseline Interferometry (VLBI) measurements of proper motion. In this paper, we discuss and quantify the prospects for the use of radio VLBI observations and observations of scintillation-induced variability to measure the source size and proper motion of merger afterglows, and thereby infer properties of the merger including inclination angle, opening angle, and energetics. We show that these techniques are complementary as they probe different parts of the circum-merger density/inclination angle parameter space and different periods of the temporal evolution of the afterglow. We also find that while VLBI observations will be limited to the very closest events it will be possible to detect scintillation for a large fraction of events beyond the range of current gravitational wave detectors. Scintillation will also be detectable with next-generation telescopes such as the Square Kilometre Array, 2000 antenna Deep Synoptic Array, and the next-generation Very Large Array, for a large fraction of events detected with third-generation gravitational wave detectors. Finally, we discuss prospects for the measurement of the H0 with VLBI observations of neutron star mergers and compare this technique to other standard siren methods.
An attempt to constrain Planet Nine’s orbit and position via resonant confinement of distant TNOs
Authors: Downey Brynna G , Morbidelli Alessandro 
Published: March 2020

ABSTRACT
We considered four TNOs on elongated orbits with small semimajor axis uncertainties: Sedna, 2004 VN112, 2012 VP113, and 2000 CR105. We found two sets of simultaneous near commensurabilities for these objects with a putative Planet Nine that are compatible with the current uncertainties in the objects’ orbital periods. We conducted a large number of numerical simulations of quasi-coplanar simulations (i.e. inclinations of Planet Nine and TNOs set to zero but not the giant planets) to find which values of Planet Nine’s mean anomaly and longitude of perihelion could put these objects in stable mean motion resonance (MMR) librations. We found no cases of simultaneous stable librations for multiple TNOs for more than 800 My, with most librations lasting much shorter than this time-scale. The objects 2004 VN112 and 2000 CR105 are the most unstable. Being in an MMR is not a strict requirement for long-term survival in 3D simulations, so our result cannot be used to refute Planet Nine’s existence. Nevertheless, it casts doubt and shows that theoretical attempts to constrain the position of the planet on the sky are not possible.