bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fragmentation pattern of certain isatin–indole antiproliferative conjugates with application to identify their in vitro metabolic profiles in rat liver microsomes by liquid chromatography tandem mass spectrometry
Authors: Almutairi Maha S. , Kadi Adnan A. , Al-Wabli Reem I. , Attwa Mohamed W. , Attia Mohamed I. 
Published: June 2020

AbstractThe fragmentation pattern of certain isatin-based compounds was carried out using collision-induced dissociation inside the triple quadrupole mass analyzer. These data were used as a clue for the identification of metabolites of the recently reported isatin-based antiproliferative agent, namely, N′-[5-bromo-1-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]-5-methoxy-1H-indole-2-carbohydrazide (1) in rat liver microsomes (RLMs) using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Prediction of the vulnerable sites for metabolic pathways in compound 1 was performed by WhichP450 module of StarDrop software. In vitro metabolites for compound 1 were identified with the aid of rat liver microsomes. The in silico data were utilized as a guide for the practical work. Compound 1 was metabolized into three (hydroxylated, reduced and O-demethylated) metabolites in RLMs in the presence of NADPH. The chemical structures of those metabolites were elucidated, and the metabolic pathways were proposed by comparing the fragmentation pattern of the isatin–indole conjugates 1–7. The data presented in this paper provided useful information on the effect of different substituents on the ionization/fragmentation processes and can be used in the characterization of isatin derivatives. In silico toxicity assessments for the title compounds 1–7 and for the metabolites of compound 1 were conducted utilizing the deductive estimation of risk from existing knowledge (DEREK) module of StarDrop software.
Reaction characteristics of polymer expansive jet impact on explosive reactive armour
Authors: Yi Jianya , Wang Zhijun , Yin Jianping , Zhang Zhimin 
Published: June 2020

Abstract
In this study, a new damage mode for the explosive reactive armour (ERA) of a shaped charge jet was proposed. The response characteristics of polytetrafluoroethylene (PTFE) and polyamide (PA) polymer jet impact on the ERA were analysed. The expansion degree and the diameter of the PTFE jet are larger than those of the PA jet, but the compactness of the PTFE jet head is lower than that of the PA jet, resulting in different impact pressures of the different polymer expansive jets on the target. The PTFE jet achieved the penetration without initiation of the ERA at different standoffs, while the PA jet directly detonated the sandwich charge when impacting the ERA vertically and failed to penetrate the front plate when impacting the ERA at 68°. With the increase of standoff, the reaction degree of the PTFE jet to the ERA decreased gradually, and the aperture of the front plate did not change.
Coerced Human Mobility and Elite Social Networks in Early Dynastic Iraq and Iran
Authors: Bartash Vitali 
Published: June 2020

Abstract
The article provides a historical analysis of cuneiform records concerning the circulation of unfree humans among the political-cultic elite in southern Mesopotamia and the Persian Gulf during the Early Dynastic IIIb period, ca. 2475–2300 BCE. The analysis of the written data from the Adab city-state demonstrates that the royal house used the unfree as gifts to maintain a sociopolitical network on three spatial levels – the internal, local, and (inter)regional. The gift-givers and gift-receivers were mostly male adult members of the local and foreign elite, whereas the dislocated unfree humans were heterogeneous in terms of age, gender, and the ways they lost their freedom. The author relates the social profiles of both groups to the logistics of human traffic to reveal the link between social status and forms and nature of spatial mobility in the politically and socially unstable Early Dynastic Near East.
Werte in Betrieb?
Authors: Steinberg Swen 
Published: June 2020

Abstract
The article focuses on the connection between individual Christian religiosity, the patriarchal derivations for ideas of corporate order and the reaction to the labour or sales market using the example of the Saxon-Protestant pulp and paper enterprise Kübler & Niethammer. It shows that in late 19th and early 20th century, religion could be understood in a functional way in entrepreneurial contexts and therefore used flexibly: religious practices formulated as expectations by Christian entrepreneurs could develop into negotiating spaces between the workforce and the market. The latter is analysed in more detail using the example of work on Sundays. At the same time, this article points to the potential of studying industrialised rural regions, in which the connection between religion, business and the market still played a role in the first half of the 20th century – and probably beyond.
Characterizing overstretched NTRU attacks
Authors: De Micheli Gabrielle , Heninger Nadia , Shani Barak 
Published: June 2020

AbstractOverstretched NTRU is a variant of NTRU with a large modulus. Recent lattice subfield and subring attacks have broken suggested parameters for several schemes. There are a number of conflicting claims in the literature over which attack has the best performance. These claims are typically based on experiments more than analysis. In this paper, we argue that comparisons should focus on the lattice dimension used in the attack. We give evidence, both analytically and experimentally, that the subring attack finds shorter vectors and thus is expected to succeed with a smaller dimension lattice than the subfield attack for the same problem parameters, and also to succeed with a smaller modulus when the lattice dimension is fixed.
A subexponential-time, polynomial quantum space algorithm for inverting the CM group action
Authors: Jao David , LeGrow Jason , Leonardi Christopher , Ruiz-Lopez Luis 
Published: June 2020

AbstractWe present a quantum algorithm which computes group action inverses of the complex multiplication group action on isogenous ordinary elliptic curves, using subexponential time, but only polynomial quantum space. One application of this algorithm is that it can be used to find the private key from the public key in the isogeny-based CRS and CSIDH cryptosystems. Prior claims by Childs, Jao, and Soukharev of such a polynomial quantum space algorithm for this problem are false; our algorithm (along with contemporaneous, independent work by Biasse, Iezzi, and Jacobson) is the first such result.
Identification of four genes associated with cutaneous metastatic melanoma
Authors: Ji Chen , Li Yuming , Yang Kai , Gao Yanwei , Sha Yan , Xiao Dong , Liang Xiaohong , Cheng Zhongqin 
Published: June 2020

Abstract

Background
Cutaneous melanoma is an aggressive cancer with increasing incidence and mortality rates worldwide. Metastasis is one of the primary elements that influence the prognosis of patients with cutaneous melanoma. This study aims to clarify the potential mechanism underlying the low survival rate of metastatic melanoma and to search for novel target genes to improve the survival rate of patients with metastatic tumors.

Methods
Gene expression dataset and clinical data were downloaded from The Cancer Genome Atlas portal. Differentially expressed genes (DEGs) were identified, and their functions were studied through gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses. Survival and multivariate Cox regression analyses were used to screen out candidate genes that could affect the prognosis of patients with metastatic melanoma.

Results
After a series of comprehensive statistical analysis, 464 DEGs were identified between primary tumor tissues and metastatic tissues. Survival and multivariate Cox regression analyses revealed four vital genes, namely, POU2AF1, ITGAL, CXCR2P1, and MZB1, that affect the prognosis of patients with metastatic melanoma.

Conclusion
This study provides a new direction for studying the pathogenesis of metastatic melanoma. The genes related to cutaneous metastatic melanoma that affect the overall survival time of patients were identified.
From Moral Principles to Political Judgments: The Case for Pragmatic Idealism
Authors: Vandamme Pierre-Étienne 
Published: June 2020

AbstractPolitical judgments usually combine a normative principle or intuition with an appreciation of empirical facts regarding the achievability of different options and their potential consequences. The interesting question dividing partisans of political idealism and realism is whether these kinds of considerations should be integrated into the normative principles themselves or considered apart. At first sight, if a theorist is concerned with guiding political judgments, non-ideal or realist theorizing (directly integrating such considerations) can seem more attractive. In this article, however, I argue that ideal theorizing might be considered valuable even by theorists moved by a pragmatic concern (guiding political judgments) because it is less exposed to conservatism. I nonetheless contend that the aim to guide action in the world as it is should not be abandoned. Therefore, I outline a four-step method for proceeding from abstract moral principles to concrete political judgments and apply it to a test case.
The crystal structure of 4a-formyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydro-1-2-6a,6b,9,9,12a-heptamethylpicen-10-yl acetate, C32H50O3
Authors: Latolla Nehemiah , Hosten Eric C. , Hlangothi Buyiswa G. 
Published: June 2020

Abstract
C32H50O3, orthorhombic, P212121 (no. 19), a = 8.0417(5) Å, b = 11.7996(6) Å, c = 30.1631(16) Å, V = 2862.1(3) Å3, Z = 4, R
gt(F) = 0.0712, wR
ref(F
2) = 0.2046, T = 296(2) K.
Integrated road traffic noise mapping in urban Indian context
Authors: Sonaviya Dipeshkumar R. , Tandel Bhaven N. 
Published: June 2020

Abstract
Road traffic noise has been recognized as a serious issue that affects the urban regions. Due to urbanization and industrialization, transportation in urban areas has increased. Traffic noise characteristics in cities belonging to a developing country like India are highly varied compared to developed nations because of its heterogeneous conditions. The objective of the research study is to assess noise pollution due to heterogeneous traffic conditions and the impact of horn honking due to un-authorized parked vehicles on the main roadside. Noise mapping has been done using the computer simulation model by taking various noise sources and noise propagation to the receiver point. Traffic volume, vehicular speed, noise levels, road geometry, un-authorized parking, and horn honking were measured on tier-II city roads in Surat, India. The study showed not so significant correlation between traffic volume, road geometry, vehicular speed and equivalent noise due to heterogeneous road traffic conditions. Further, analysis of traffic noise showed that horn honking due to un-authorized parked vehicles contributed an additional up to 11 dB (A), which is quite significant. The prediction models such as U.K’s CoRTN, U.S’s TNM, Germany’s RLS-90 and their modified versions have limited applicability for heterogeneity. Hence, the noise prediction models, which can be used for homogeneous road traffic conditions are not successfully applicable in heterogeneous road traffic conditions. In this research, a new horn honking correction factor is introduced with respect to unauthorized parked vehicles. The horn honking correction values can be integrated into noise model RLS-90, while assessing heterogeneous traffic conditions.
Nuevas propuestas para viejos desafíos: Desenmarañando el régimen de cambio climático
Authors: Chapagain Masís Rajesh 
Published: June 2020

Debido al alcance global del cambio climático, las medidas o “curas” dirigidas a solucionar o “aliviar” el problema deben de ser acordadas e implementadas mediante la acción colectiva de los actores del sistema internacional, en especial los Estados, lo que lo hace un desafío para la gobernanza internacional. Con eseobjetivo, en las últimas décadas se ha desarrollado el régimen internacional de cambio climático, un proceso complejo y que sigue siendo un trabajo en progreso. En ese sentido, el estudio de las Relaciones Internacionales debe buscar la mejora en la comprensión del contexto político internacional que enmarcaese proceso y contribuye a la toma de decisiones efectivas (Underdal, 2017).
Recreational Drugs: a New Health Hazard for Patients with Concomitant Chronic Liver Diseases
Authors: Tarantino Giovanni , Citro Vincenzo , Finelli Carmine 
Published: June 2020

Our purpose in this article is to review the effects of recreational drugs, used either on their own but principally combined with alcohol consumption, in determining hepatic injury or influencing the evolution of some chronic diseases of the liver, specifically HCV infection and NAFLD. A deleterious role of daily use of recreational drugs, in particularly cannabis, has been shown to demonstrate clearly a rapid progression of fibrosis and steatosis, leading to a major severity in patients with chronic hepatitis C. On the other hand, the effects of the misuse of these substances on NAFLD, the main obesity-related comorbidity, leading to addiction, is still to be elucidated even though some clues to the recreational drugs hepatotoxicity are already present in the literature. This short review aims at raising awareness about this topic.
Improving HPV Vaccination Rates: A Stepped-Wedge Randomized Trial
Authors: Perkins Rebecca B. , Legler Aaron , Jansen Emily , Bernstein Judith , Pierre-Joseph Natalie , Eun Terresa J. , Biancarelli Dea L. , Schuch Thomas J. , Leschly Karin , Fenton Anny T.H.R. , Adams William G. , Clark Jack A. , Drainoni Mari-Lynn , Hanchate Amresh 
Published: June 2020

OBJECTIVES:
To evaluate the effectiveness of a stepped-wedge randomized trial of Development of Systems and Education for Human Papillomavirus Vaccination (DOSE HPV), a multilevel intervention.

METHODS:
DOSE HPV is a 7-session program that includes interprofessional provider education, communication training, data feedback, and tailored systems change. Five primary care pediatric and/or family medicine practices completed interventions between 2016 and 2018; all chose to initiate vaccination at ages 9 to 10. We compared vaccination rates in the preintervention, intervention, and postintervention periods among 9- to 17-year-olds using random-effects generalized linear regression models appropriate for stepped-wedge design, accounting for calendar time and clustering of patients by providers and clinic. Outcomes included (1) the likelihood that eligible patients would receive vaccination during clinic visits; (2) the likelihood that adolescents would complete the series by age 13; and (3) the cumulative effect on population-level vaccine initiation and completion rates. Postintervention periods ranged from 6 to 18 months.

RESULTS:
In the intervention and postintervention periods, the adjusted likelihood of vaccination at an eligible visit increased by &gt;10 percentage points for ages 9 to 10 and 11 to 12, and completion of the vaccine series by age 13 increased by 4 percentage points (P &lt; .001 for all comparisons). Population-level vaccine initiation coverage increased from 75% (preintervention) to 84% (intervention) to 90% (postintervention), and completion increased from 60% (preintervention) to 63% (intervention) to 69% (postintervention).

CONCLUSIONS:
Multilevel interventions that include provider education, data feedback, tailored systems changes, and early initiation of the human papillomavirus vaccine series may improve vaccine series initiation and completion beyond the conclusion of the intervention period.
New Pampas cat Leopardus colocolo (Molina, 1782) (Mammalia: Carnivora: Felidae) records for the Chaco ecoregion raise questions on the distribution and population status of this felid in Argentina
Authors: Nanni Ana Sofía , Castro Lucila , Cuyckens Griet An Erica , Barri Fernando R. , Giordano Anthony J. , Lucherini Mauro 
Published: June 2020

The Pampas cat is a poorly-known small felid distributed throughout a large portion of South America, reported as extinct in the Pampas of Argentina, and absent from a large portion of the Argentine Dry Chaco. Here, we compile data from the field and collections to report new presence records of the Pampas cat from the Dry Chaco of Argentina, which update to the distribution of this felid in the region. We discuss the need of further assessments for the species distribution in the light of ongoing land-use changes in the area.
Impact of increasing atmospheric CO2 concentration on growth characteristics and yield in maize and rice
Authors: Xie X. J. , Li R.Y. , Huang L.D. , Bao Y.X. 
Published: June 2020

To assess the effect of increasing atmospheric CO2 concentration ([CO2]) on growth and yield in maize and rice, an experiment was carried out in open top chambers (OTCs) at different atmospheric CO2 concentration treatments (550 ?mol/mol, T1; 750 ?mol/mol, T2 and a control, CK) in Nanjing, Jiangsu, China. Our results indicated that the plant height, leaf area index (LAI), Soil and Plant Analyzer Development (SPAD) and net photosynthesis (NPn) of the maize (Zhengdan 958) and rice (Huaidao 5) at three development stages under the increasing [CO2] followed the order of CK <T1<T2. The growth indexes of two crop cultivars showed no significant differences nor did they show significant differences at certain development stages among the three CO2 treatments. The growth durations of maize and rice were delayed due to the elevated [CO2] treatments individually, but the impact before jointing was slightly greater than that after jointing. The above-ground biomass in maize was increased by 6.70–10.10%, and the above-ground biomass in rice was increased by 8.98–13.74% (P < 0.05) under the elevated [CO2] treatments. Maize yields were increased by 5.26% and 11.45%, and rice yields were increased by 19.76% and 24.43% under the T1 and T2 treatments. Other yield components of two crop cultivars were enhanced accordingly under high [CO2] treatments. The kernels per spike and crop yield showed significant differences between two high [CO2] plots and CK (P < 0.05). However, there were no significant differences for other yield components (P > 0.05).
Empoderamento e feminismo negro: decolonizando epistemologias e mentalidades
Authors: Berth Joice , Pinheiro dos Santos Naira , Menezes Nilza , Kikuchi Campanaro Priscila 
Published: June 2020

Joice Berth Entrevista por Naira Pinheiro dos Santos, Nilza Menezes e Priscila Kikuchi Campanaro
Kewenangan Notaris dalam Membuat Akta Roya Hak Tanggungan
Authors: Purnama Yusuf Bagus 
Published: June 2020

Akta roya hak tanggungan biasanya dibuat oleh Kantor Pertanahan yang menandakan bahwa piutang kreditor telah lunas atau sertifikat hak tanggungan dicoret karena sudah hapus. Namun karena sertifikat hak tanggungan yang dikuasai oleh kreditor hilang, maka dalam hal hak tanggunganya hapus tidak bisa dilakukan pencoretan dalam sertifikat hak tanggungan. Dalam hal ini kreditor memerlukan akta roya hak tanggungan secara notariel atau akta yang dibuat oleh notaris. Akta roya hak tanggungan merupakan salah satu akta otentik yang dibuat notaris atas permintaan kreditor sebagai pihak yang berisi pernyataan pihak kreditur bahwa sertipikat hak tanggungan debitor yang berada dalam kekuasaannya telah hilang. Keberadaan akta roya hak tanggungan dalam ruang lingkup hak tanggungan belum diatur secara tegas dalam UUJN, UUHT dan peraturan lainnya, namun notaris dapat membuat akta ini dengan berlandaskan kewenangan notaris sebagaimana Pasal 15 ayat (1) UUJN. Dalam ketentuan tersebut terdapat adanya norma kabur mengenai kewenangan notaris untuk membuat akta roya hak tanggungan. Permasalahan yang diangkat dalam penelitian ini adalah tentang kewenangan notaris membuat akta roya hak tanggungan, dan kedudukan aka roya hak tanggungan yang dibuat oleh notaris. Hasil penelitian ini menunjukkan bahwa secara umum notaris berwenang membuat akta notariel berupa akta roya hak tanggungan berdasarkan Pasal 15 ayat (1) UUJN, selama tidak ada aturan lain yang lebih khusus mengatur hal tersebut. Akta roya hak tanggungan merupakan akta notariil yang mempunyai kedudukan sebagai pengganti sertifikat hak tanggungan yang hilang, yang berfungsi sebagai syarat pendaftaran roya atau pencoretan hak tanggungan.
Pembiayaan Berbasis Teknologi Informasi (Fintech) yang Berdasarkan Syariah
Authors: Alwi Achmad Basori 
Published: June 2020

Dalam era perkembangan ekonomi digital, masyarakat terus mengembangkan inovasi penyediaan layanan dalam kegiatan pinjam meminjam uang yang salah satunya ditandai dengan adanya penyediaan Layanan Jasa Pinjam meminjam Uang Berbasis Teknologi Informasi yang dinilai turut berkontribusi terhadap pembangunan dan perekonomian nasional. Salah satunya adalah sistem pembiayaan dengan cara mempertemukan pihak yang mengajukan pembiayaan dengan pihak yang memberikan pendanaan secara online.Hal tersebut difasilitasi melalui Layanan pinjam meminjam uang berbasis teknologi informasi (fintech) secara syariah. Adapun alasan diluncurkan layanan fintech berbasis syariah adalah untuk mengakomodir pengguna jasa yang menginginkan transaksi pijam meminjam berbasis syariah
Layanan fintech berbasis syariah selain memberikan penawaran dan skema yang berbeda dari layanan yang sudah ada (konvensional), juga memberikan pembatasan pembatasan tertentu terhadap penggunaan dana yang di berikan oleh investor atau pemberi pinjaman. Permintaan pengguna jasa layanan fintech berbasis syariah yang meningkat yang di dukung dengan pangsa pasar pengguna layanan dari masyarakat Indonesia yang mayoritas muslim mendorong Layanan Fintech berbasis syariah wajib memenuhi kaidah kaidah dalam transaksi bisnis secara syariah.
Tanggung Gugat Perebedaan Luas Tanah Secara Faktual dengan Luas Tanah di Sertifikat
Authors: Dewi Ida Ayu Febri Anasia 
Published: June 2020

Tujuan dari penulisan ini adalah untuk mengetahui bagaimanakah tanggung gugat perbedaan luas tanah secara faktual dengan luas tanah di sertifikat. Di akhir tulisan disimpulkan dua hal. Pertama, surat ukur berfungsi ketika muncul kesalahan teknis/perubahan berkenaan dengan data fisik dari suatu bidang tanah yang berakibat pada perubahan bats dan luasnya, di samping juga berfungsi menjelaskan tentang letak, luas dan batas dari suatu bidang tanah atau dari satuan rumah susun. Kedua, guna pembuatan surat ukur maka dilakukan pengukuran luas bidang tanah dan ternyata terdapat kelalaian, maka yang bisa diperoleh oleh pihak yang dirugikan ialah bentuk perlindungan hukum preventif, yaitu subjek hukum mempunyai haka tau berkesempatan mengajukan pendapat atau keberatannya, dengan tujuan guna mengantisipasi lahirnya sengketa, sedangkan akibat dari kelalaian tersebut maka pejabatn terkait bisa diajukan gugatan berupa tanggung gugat pribadi.
Pengaruh Hukum Islam tentang Larangan Tuak Terhadap Perilaku Masyarakat Desa Boto Kecamatan Semanding
Authors: Habibi Husni 
Published: June 2020

This article is based on field research aims to answer the question of the influence of Islamic Law on prohibiting liquor (Tuak) towards community behavior of Boto Village in Semanding district of Tuban Regency. It also strives to analyze the factors that contribute to mold people's behavior. The approach of this research is combining a quantitative survey and qualitative research methods, with data analysis techniques in the form of analytical descriptive. The results of the study conclude that Islamic law is incapable of fashioning the actual behavior of its adherents, especially in the village of Boto. The prohibitions of liquor (tuak) failed to stimulate the behavior of rural communities under Islamic legal norms. This is indicated by the lack of community response to Islamic legal norms. On the contrary, it is conclusively found that the behavior of the majority of people deviates from the Islamic provisions of legal norms about the prohibition of liquor (tuak).