bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adequacy of neural networks for wide-scale day-ahead load forecasts on buildings and distribution systems using smart meter data
Authors: Valgaev Oleg , Kupzog Friederich , Schmeck Hartmut 
Published: November 2020

AbstractPower system operation increasingly relies on numerous day-ahead forecasts of local, disaggregated loads such as single buildings, microgrids and small distribution system areas. Various data-driven models can be effective predicting specific time series one-step-ahead. The aim of this work is to investigate the adequacy of neural network methodology for predicting the entire load curve day-ahead and evaluate its performance for a wide-scale application on local loads. To do so, we adopt networks from other short-term load forecasting problems for the multi-step prediction. We evaluate various feed-forward and recurrent neural network architectures drawing statistically relevant conclusions on a large sample of residential buildings. Our results suggest that neural network methodology might be ill-chosen when we predict numerous loads of different characteristics while manual setup is not possible. This article urges to consider other techniques that aim to substitute standardized load profiles using wide-scale smart meters data.
The contagiousness of memes: containing the spread of COVID-19 conspiracy theories in a forensic psychiatric hospital
Authors: Panchal Reena , Jack Alexander 
Published: November 2020

Summary
COVID-19 has transformed healthcare service provision. In addition to the spread of a virus, there has been an equally concerning emergence and spread of conspiracy theories. Such theories can threaten societal cohesion and adherence to the necessary public health guidance. In a forensic in-patient setting, such difficulties can be amplified. In this paper, we outline the key theory in relation to the development and spread of conspiracy theory memes. We propose primary, secondary and tertiary level responses to tackle the possible generation and spread of harmful conspiracies in the forensic in-patient setting. We consider this to be important, as there is a risk that such beliefs could affect patients’ mental health and, in extremis, undermine physical health efforts to reduce the spread of COVID-19.
Duchenne muscular dystrophy (DMD) cardiomyocyte-secreted exosomes promote the pathogenesis of DMD-associated cardiomyopathy
Authors: Gartz Melanie , Lin Chien-Wei , Sussman Mark A. , Lawlor Michael W. , Strande Jennifer L. 
Published: November 2020

ABSTRACT
Cardiomyopathy is a leading cause of early mortality in Duchenne muscular dystrophy (DMD). There is a need to gain a better understanding of the molecular pathogenesis for the development effective therapies. Exosomes (exo) are secreted vesicles and exert effects via their RNA, lipid and protein cargo. The role of exosomes in disease pathology is unknown. Exosomes derived from stem cells have demonstrated cardioprotection in the murine DMD heart. However, it is unknown how the disease status of the donor cell type influences exosome function. Here, we sought to determine the phenotypic responses of DMD cardiomyocytes (DMD-iCMs) after long-term exposure to DMD cardiac exosomes (DMD-exo). DMD-iCMs were vulnerable to stress, evidenced by production of reactive oxygen species, the mitochondrial membrane potential and cell death levels. Long-term exposure to non-affected exosomes (N-exo) was protective. By contrast, long-term exposure to DMD-exo was not protective, and the response to stress improved with inhibition of DMD-exo secretion in vitro and in vivo. The microRNA (miR) cargo, but not exosome surface peptides, was implicated in the pathological effects of DMD-exo. Exosomal surface profiling revealed N-exo peptides associated with PI3K-Akt signaling. Transcriptomic profiling identified unique changes with exposure to either N- or DMD-exo. Furthermore, DMD-exo miR cargo regulated injurious pathways, including p53 and TGF-beta. The findings reveal changes in exosomal cargo between healthy and diseased states, resulting in adverse outcomes. Here, DMD-exo contained miR changes, which promoted the vulnerability of DMD-iCMs to stress. Identification of these molecular changes in exosome cargo and effectual phenotypes might shed new light on processes underlying DMD cardiomyopathy.
This article has an associated First Person interview with the first author of the paper.
Risk of colorectal cancer in patients with diabetes mellitus: A Swedish nationwide cohort study
Authors: Ali Khan Uzair , Fallah Mahdi , Sundquist Kristina , Sundquist Jan , Brenner Hermann , Kharazmi Elham 
Published: November 2020

BackgroundColorectal cancer (CRC) incidence is increasing among young adults below screening age, despite the effectiveness of screening in older populations. Individuals with diabetes mellitus are at increased risk of early-onset CRC. We aimed to determine how many years earlier than the general population patients with diabetes with/without family history of CRC reach the threshold risk at which CRC screening is recommended to the general population.Methods and findingsA nationwide cohort study (follow-up:1964–2015) involving all Swedish residents born after 1931 and their parents was carried out using record linkage of Swedish Population Register, Cancer Registry, National Patient Register, and Multi-Generation Register. Of 12,614,256 individuals who were followed between 1964 and 2015 (51% men; age range at baseline 0–107 years), 162,226 developed CRC, and 559,375 developed diabetes. Age-specific 10-year cumulative risk curves were used to draw conclusions about how many years earlier patients with diabetes reach the 10-year cumulative risks of CRC in 50-year-old men and women (most common age of first screening), which were 0.44% and 0.41%, respectively. Diabetic patients attained the screening level of CRC risk earlier than the general Swedish population. Men with diabetes reached 0.44% risk at age 45 (5 years earlier than the recommended age of screening). In women with diabetes, the risk advancement was 4 years. Risk was more pronounced for those with additional family history of CRC (12–21 years earlier depending on sex and benchmark starting age of screening). The study limitations include lack of detailed information on diabetes type, lifestyle factors, and colonoscopy data.ConclusionsUsing high-quality registers, this study is, to our knowledge, the first one that provides novel evidence-based information for risk-adapted starting ages of CRC screening for patients with diabetes, who are at higher risk of early-onset CRC than the general population.
Genetic loci associated with prevalent and incident myocardial infarction and coronary heart disease in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium
Authors: Hahn Julie , Fu Yi-Ping , Brown Michael R. , Bis Joshua C. , de Vries Paul S. , Feitosa Mary F. , Yanek Lisa R. , Weiss Stefan , Giulianini Franco , Smith Albert Vernon , Guo Xiuqing , Bartz Traci M. , Becker Diane M. , Becker Lewis C. , Boerwinkle Eric , Brody Jennifer A. , Chen Yii-Der Ida , Franco Oscar H. , Grove Megan , Harris Tamara B. , Hofman Albert , Hwang Shih-Jen , Kral Brian G. , Launer Lenore J. , Markus Marcello R. P. , Rice Kenneth M. , Rich Stephen S. , Ridker Paul M. , Rivadeneira Fernando , Rotter Jerome I. , Sotoodehnia Nona , Taylor Kent D. , Uitterlinden André G. , Völker Uwe , Völzke Henry , Yao Jie , Chasman Daniel I. , Dörr Marcus , Gudnason Vilmundur , Mathias Rasika A. , Post Wendy , Psaty Bruce M. , Dehghan Abbas , O’Donnell Christopher J. , Morrison Alanna C. 
Published: November 2020

Background
Genome-wide association studies have identified multiple genomic loci associated with coronary artery disease, but most are common variants in non-coding regions that provide limited information on causal genes and etiology of the disease. To overcome the limited scope that common variants provide, we focused our investigation on low-frequency and rare sequence variations primarily residing in coding regions of the genome.

Methods and results
Using samples of individuals of European ancestry from ten cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, both cross-sectional and prospective analyses were conducted to examine associations between genetic variants and myocardial infarction (MI), coronary heart disease (CHD), and all-cause mortality following these events. For prevalent events, a total of 27,349 participants of European ancestry, including 1831 prevalent MI cases and 2518 prevalent CHD cases were used. For incident cases, a total of 55,736 participants of European ancestry were included (3,031 incident MI cases and 5,425 incident CHD cases). There were 1,860 all-cause deaths among the 3,751 MI and CHD cases from six cohorts that contributed to the analysis of all-cause mortality. Single variant and gene-based analyses were performed separately in each cohort and then meta-analyzed for each outcome. A low-frequency intronic variant (rs988583) in PLCL1 was significantly associated with prevalent MI (OR = 1.80, 95% confidence interval: 1.43, 2.27; P = 7.12 × 10−7). We conducted gene-based burden tests for genes with a cumulative minor allele count (cMAC) ≥ 5 and variants with minor allele frequency (MAF) < 5%. TMPRSS5 and LDLRAD1 were significantly associated with prevalent MI and CHD, respectively, and RC3H2 and ANGPTL4 were significantly associated with incident MI and CHD, respectively. No loci were significantly associated with all-cause mortality following a MI or CHD event.

Conclusion
This study identified one known locus (ANGPTL4) and four new loci (PLCL1, RC3H2, TMPRSS5, and LDLRAD1) associated with cardiovascular disease risk that warrant further investigation.
Perinatal outcome of meconium stained amniotic fluid among labouring mothers at teaching referral hospital in urban Ethiopia
Authors: Tolu Lemi Belay , Birara Malede , Teshome Tesfalem , Feyissa Garumma Tolu 
Published: November 2020

ObjectiveTo determine the perinatal outcome of labouring mothers with meconium-stained amniotic fluid (MSAF) compared with clear amniotic fluid at teaching referral hospital in urban Ethiopia.MethodsA prospective cohort study was conducted among labouring mothers with meconium-stained amniotic fluid from July 1 to December 30, 2019. Data was collected with pretested structured questionnaires. A Chi-square test used to check statistical associations between variables. Those variables with a p-value of less than 0.05 were selected for cross-tabulation and binary logistic regression. P-value set at 0.05, and 95% CI was used to determine the significance of the association. Relative risk was used to determine the strength and direction of the association.ResultAmong 438 participants, there where 75(52.1%) primigravida in a stained fluid group compared to112 (38.5%) of the non-stained fluid group. Labour was induced in 25 (17.4%) of the stained fluid group compared to 25(8.6%) of a non-stained fluid group and has a statistically significant association with meconium staining. The stained fluid group was twice more likely to undergo operative delivery compared with a non-stained fluid group. There were more low Apgar scores at birth (36.8% versus 13.2%), birth asphyxias (9% versus 2.4%), neonatal sepsis (1% versus 5.6%), neonatal death (1% versus 9%), and increased admissions to neonatal intensive care unit (6.2% versus 21.5%) among the meconium-stained group as compared to the non-stained group. Meconium aspiration syndrome was seen in 9(6.3%) of the stained fluid group.ConclusionMeconium-stained amniotic fluid is associated with increased frequency of operative delivery, birth asphyxia, neonatal sepsis, and neonatal intensive care unit admissions compared to clear amniotic fluid.
Are childbirth location and mode of delivery associated with favorable early breastfeeding practices in hard to reach areas of Bangladesh?
Authors: Ali Nazia Binte , Karim Farhana , Billah S. K. Masum , Hoque Dewan M. D. Emdadul , Khan Abdullah Nurus Salam , Hasan Mohammad Mehedi , Simi Sonjida Mesket , Arifeen Shams E. L. , Chowdhury Mohiuddin Ahsanul Kabir 
Published: November 2020

BackgroundEarly initiation of breastfeeding within one hour of birth (EIBF) and no prelacteal feeding are WHO recommended practices for improving maternal and newborn health outcomes. Globally, EIBF can avert around 22% of newborn death. In recent years, Bangladesh has experienced increasing facility delivery coverage and cesarean section rates. However, the impact of these changes on early breastfeeding initiation in hard to reach areas (HtR) of the country is still poorly understood. Therefore, this study aimed to examine the independent associations between childbirth locations and mode of delivery with favorable early breastfeeding practices in four hard to reach areas of Bangladesh.MethodWe extracted data from a cross-sectional study conducted in four HtR areas of Bangladesh in 2017. A total of 2768 women, having birth outcomes in the past 12 months of the survey, were interviewed using structured questionnaires. EIBF and no prelacteal feeding were considered as favorable early breastfeeding practices. The categories of childbirth locations were defined by the place of birth (home vs. facility) and the delivery sector (public/NGO vs. private). The mode of delivery was categorized into vaginal delivery and cesarean section. Generalized linear models were used to test the independent associations while adjusting for potential confounders.ResultsThe prevalence of EIBF practices were 69.6%(95% CI:67.8–71.3); 72.2%(95% CI:67.8–71.3) among home births Vs 63.0%(95% CI:59.5%-66.4%) among facility births. Around 73.9% (95% CI:72.3–75.6) mother’s in the study areas reported no-prelacteal feeding. Compared to home births, women delivering in the facilities had lower adjusted odds of EIBF (aOR = 0.51; 95%CI:0.35–0.75). Cesarean section was found to be negatively associated with EIBF (aOR = 0.20; 95%CI:0.12–0.35), after adjusting for potential confounders. We could not find any significant associations between the place of birth and mode of delivery with no prelacteal feeding.DiscussionsThis study found that facility births and cesarean deliveries were negatively associated with EIBF. Although the implementation of "Baby-Friendly Hospital Initiatives" could be a potential solution for improving EIBF and no prelacteal feeding practices, the challenges of reduced service availability and accessibility in HtR areas must be considered while devising effective intervention strategies. Future studies can explore potential interventions to promote early breastfeeding for facility births and cesarean deliveries in HtR areas.
Strabismus surgery in Angelman syndrome: More than ocular alignment
Authors: Michieletto Paola , Pensiero Stefano , Diplotti Laura , Ronfani Luca , Giangreco Manuela , Danieli Alberto , Bonanni Paolo 
Published: November 2020

PurposeTo report and evaluate strabismus surgery in children with Angelman syndrome, in order to optimize and standardize surgical approach. Other purposes are to understand the possible relation between ocular findings and motor ability, and between improvement in ocular alignment and changes in motor skills in this population.DesignObservational cross-sectional study.MethodsMedical records of pediatric patients with Angelman syndrome, who underwent strabismus surgery, were investigated. Collected data included: genotype, gender, age at the time of surgery, refractive error, pre-operative strabismus, surgical procedure, surgical outcome, gross and fine motor development assessment pre- and post-operatively.ResultsSeventeen subjects, aged 3–15 years, were investigated. Fourteen patients were exotropic, three esotropic. Most patients presented astigmatism. Considering the exaggerated response to standard amounts of surgery and the risk of consecutive strabismus on long term follow-up reported by previous studies in children with developmental delay, a reduction of the amount of strabismus surgery was applied. Post-operatively, all patients presented with a significative reduction of the baseline deviation angle, with all esotropic patients and 7 exotropic patients (59%) achieving orthotropia. The surgical outcomes were variable according to the type and the amount of baseline strabismus, but no case presented with exaggerated surgical response. At baseline, patients showed important delays in all motor abilities, and, post-operatively, presented a significant improvement in walking and fine motor tasks. Pre- and post-operative motor abilities were negatively correlated to astigmatism, anisometropia, and amount of deviation.ConclusionsAccording to our data, the standard nomograms for strabismus surgery may be successfully applied in subjects with Angelman syndrome and exotropia. Our data suggest that the reduction of the deviation angle improves motor skills in strabismic pediatric patients with Angelman syndrome.
Acute chemical ingestion in the under 19 population in South Korea: A brief report
Authors: Lee Jae Hee , Lee Duk Hee 
Published: November 2020

BackgroundMost people are frequently exposed to chemicals and chemical products. This study provides basic information on the outcomes of acute chemical ingestion of patients aged under 19 years.MethodsPatients aged under 19 years who had ingested chemicals and thus visited the emergency department between January 2011 and December 2016 were included in this study.ResultsIn all, 1,247 patients included (1,145 in the unintentional group and 102 in the intentional group). The mean age was 3.27±4.77 in the unintentional ingestion group and 16.49±1.94 in the intentional group. In the unintentional group, detergents were most frequently ingested (by 219 patients), followed by hypochlorite-based agents, ethanol, sodium hydroxide, acetone, silica gel, and citric acid. Cases of boric acid (odds ratio [OR] = 6.131), ethylene glycol (OR = 6.541), glacial acetic acid (OR = 7.644), other hydrocarbons (OR = 4.496), hypochlorite-based agent (OR = 2.627), nicotine (OR = 5.635), and sodium peroxocarbonate (OR = 6.783) ingestion was associated with a significantly high admission rate. In the intentional group, there were 54 cases of ingestion of hypochlorite-based agent, followed by detergent, ethylene glycol, ethanol, methanol and sodium peroxycarbonate. The significant risk factors for admission in the intentional group were ingestion of ethylene glycol (OR = 37.333) and hypochlorite-based agent (OR = 5.026). There was no mortality case.ConclusionThe most commonly ingested substances were sodium hypochlorite (hypochlorite-related agent), surfactants (detergent and soap), and ethanol. The ingestion of hypochlorite or ethylene glycol was the main risk factor for admission. Intentional ingestion was higher in adolescents than in children.
Dear Alja
Authors: Alfirević Dragana 
Published: November 2020

Abstract
The author is writing a letter in times of uncertainty and the stoppage of nomadic currents in which she had, until recently, been a part of. Her writing offers perspective: as a producer, artist and choreographer, she is questioning the most fundamental matters of the changed nowness; she is asking what body displays vulnerability and the lack of knowledge regarding the future in which there is nothing but the present and the vacuum of home environment. She wonders how the current situation will cut in the intersubjective relations, how it will bend live art that so fundamentally determines who she is, and how we can reconceptualize the basic category of domestic to grant it its necessary politicality.
Hysteria and hypochondria: Sexual discrimination through the lens of sickness
Authors: Pezelj Andrej 
Published: November 2020

Abstract
The article deals with certain aspects of discriminating women through the relation between hypochondria and hysteria. It focuses mostly on the second half of the 18th and the first half of the 19th century. The objective of the article is not to give an exhaustive analysis of these pathologies, but rather to give examples of how the changes in medicine influence the perception of women. The examples of these two pathologies show how medicine was dominated by the idea of an order of nature where woman could not be considered as an individual. Instead of healing, the function of medicine was often to use new knowledge to explain and approve a pre-existing order of nature.
Tongueney
Authors: Ograjenšek Domen 
Published: November 2020

Abstract
On its way to the roof of the mouth, her tongue veers off its path and takes the daring trail past the alveolar ridge and teeth, landing on the lips – it is no longer Britney, but the “tongueney”. This is no subjectivity; it is a schizoid sound system that is already penetrating us: full of high-pitched notes, ear worms, conspiratorial intonations of sound imaginaries, screams of disintegrating subjectivities and developing simulacra.
Back to the future: On continuities and discontinuities in the history of Maska
Authors: Milohnić Aldo 
Published: November 2020

Abstract
The last century saw quite a few cases of establishing, cancelling and relaunching of theatre journalism in Slovenia – Maska also being part of this “vicious circle”, which often began “from the beginning”. On the other hand, it seems that Maska is the one that has managed to surpass this history of constant beginnings as it has now been in regular circulation for almost 30 years, ever since it reclaimed its original name in 1991. The journal could not escape temporary crises, yet Maska has so far always been able to gather enough strength to throw away these shackles and survive. The author presents and analyses the history of Maska from its foundation to the present day, draws attention to certain key milestones, and in particular highlights the magazine’s productive connections between theatre theory and practice.
ABORDAJE MULTIDIMENSIONAL DEL SISTEMA SUELO DEL PERIURBANO, EN LA REGIÓN SUR DE SANTA FE
Authors: ARADAS DÍAZ M. E. , BENEDETTO V. , CARDOZO F. , LONGO A. , TIMONI R. 
Published: November 2020

El sistema suelo del periurbano, está cruzado por múltiples dimensiones y actores que complejizan su gestión. En la Plataforma de Innovación Territorial (PIT) del Instituto Nacional de Tecnología Agropecuaria (INTA) de Oliveros, se han identifi cado las dimensiones: económica/productiva, geográfi ca, ecológica y ambiental, organizativo-política, sociocultural, tecnológica e institucional. El objetivo de este trabajo fue profundizar el concepto y la gestión multidimensional del suelo del periurbano a través de la plataforma (PIT), vinculándolos a los objetivos institucionales del INTA. Metodológicamente se realizó un abordaje de sistemas complejos, con la descripción de los componentes/dimensiones y sus relaciones en el periurbano como unidad de análisis y la relación con los objetivos institucionales. Los resultados de la interacción entre las dimensiones permiten vincular conceptos como diversidad productiva, espacio crítico, territorio en disputa, diversidad de calidad y tipos de suelo, defi ciencia en la gobernanza, heterogeneidad en el tamaño y formas de uso del suelo, tenencia de la tierra, leyes y ordenanzas de regulación, diversidad de actores involucrados, entre otras, que muestra un abordaje multidimensional, que a su vez se encuentran vinculados a los objetivos institucionales: competitividad, equidad y salud ambiental. El enfoque sistémico facilita la comprensión y dimensionamiento del sistema suelo del periurbano como espacio vivo donde sus propiedades emergen de las interacciones entre las dimensiones que lo componen.