bluuebunny/crossref_metadata_2025_split huggingface dataset:
PROGNOSTIC SIGNIFICANCE OF MONORESISTANCE GENE EXPRESSION IN TUMORS OF PATIENTS WITH NON-SMALL CELL LUNG CANCER AFTER PREOPERATIVE CHEMOTHERAPY
Authors: Kzhyshkovska Yuliya , Cherdyntseva Nadezhda , Tuzikov Sergey , Pisareva Lyubov , Ibragimova Marina , Miller Sergey , Deryusheva Irina , Rodionov Yevgeniy , Tsyganov Matvey , Litvyakov Nikolay 
Published: November 2020

A significant role in the development of lung tumor resistance to drug therapy play so called mono resistance genes that determine resistance/sensitivity of tumor cells to distinct chemotherapeutic agents, they include BRCA1, RRM1, ERCC1, TOP1, TOP2a, TUBB3, TYMS, ABCC5 genes. It is shown that the use of these biomarkers as a criteria to appoint the adequate postoperative chemotherapy is associated with the forecast. However in the course of neoadjuvant chemotherapy change the expression profile of these genes can occur, which can lead to misinterpretation of results. In this regard perspective is the development of new relevant prognostic factors, which take into account occurred molecular genetic alterations in lung tumors after preoperative therapy. We presented the results of the combined treatment of 52 patients with NSCLC IIA - IIIB stage, based on the analysis of chemotherapy resistance/sensitivity gene expression for appointment the suitable drugs. It was found that the lack of expression of ERCC1 gene in lung tumor derived after neoadjuvant chemotherapy is associated with high rates of disease-free survival (P. = 0,00913). Low level expression of RRM1 gene (less than 0.5) is also associated with high rates of patient's survival (log-rank test P. = 0,01808), while a high level is a marker of poor prognosis. It is found that the combination of enhanced expression (>0.5) of any two or three genes: RRM1, ABCC5, TYMS, are the indicators of poor disease-free survival. We have shown that expression of ERCC1 gene is the independent prognostic factor. At zero ERCC1 expression in lung tumors, regardless of high or low level of expression of RRM1, ABCC5, TYMS genes, a high recurrence-free survival is observed. Thus, the data suggest the prognostic significance of the expression of ERCC1, TUBB3, RRM1, ABCC5 and TYMS genes in the lung tumor after neoadjuvant chemotherapy.
PENGGUNAAN KOMIK UNTUK MENGEMBANGKAN KETERAMPILAN MENYAMPAIKAN PENDAPAT SISWA PADA PEMBELAJARAN BAHASA INDONESIA KELAS IV SD/MI
Authors: Dea Amelia H  
Published: November 2020

Tidak semua anak di Sekolah Dasar sudah bisa menyampikan pendapat, beberapa anak masih enggan bahkan cenderung pasif dan diam saat diminta menyampaikan pendapat. Hal tersebut disebabkan karena anak masih mengalami kesulitan dalam mengekspresikan apa yang ada dalam pikiran dan perasaannya, anak belum terlatih untuk dapat menyampaikan pendapatnya, serta kurangnya media yang digunakan guru dalam proses pembelajaran di kelas. Oleh karena itu, peneliti tertarik untuk menggunakan media komik untuk mengembangkan keterampilan menyampaikan pendapat siswa.
Penelitian ini menggunakan jenis penelitian Eksperimen Semu (Quasi Experimental), dengan desain eksperimen one group pretest-posttest. Teknik pengumpulan data berupa test, wawancara dan dokumentasi. Hasil penelitian menunjukan bahwa ada keberhasilan dalam penggunaan komik terhadap keterampilan menyampaikan pendapat peserta didik di kelas IV MI Ma’arif NU 02 Tamansari. Penelitian menunjukan adanya peningkatan nilai rata-rata kemampuan menyampaikan pendapat pada pretest sebesar 65,51, kemudian nilai rata-rata meningkat pada posttest menjadi 84. Hal tersebut didukung dengan hasil perhitungan uji t test pada keterampilan menyampaikan pendapat siswa dan sig (0,000) < 0,05. Data tersebut menunjukan bahwa media pembelajaran komik berpengaruh dalam mengembangkan keterampilan menyampaikan pendapat siswa.
IMPLEMENTASI MEDIA BERBASIS AUDIO VISUAL DALAM PEMBELAJARAN MATERI GERAKAN SHOLAT FIQIH (STUDI KASUS DIKELAS V MIN 1 BANYUMAS)
Authors: Rizki Fitrianto  
Published: November 2020

Abstract
In effective learning in a classroom, it requires a variety of media that makes it easier for students to absorb the learning conveyed by the teacher. Therefore, the teacher is required to be able to convey the material correctly and correctly. From there the researchers wanted to conduct a research with the formulation of the problem of how the use of audio visual media in the ability to practice reading and prayer movements in the study of jurisprudence. The subjects in this study were grade V students with 30 students consisting of 18 women and 12 men. The method in this study used a descriptive (qualitative) method. Data collection used is observation, interview and documentation, which are then analyzed using the data reduction techniques described. In accordance with the results of the analysis conducted by researchers, students who scored above the Minimum Mastery Criteria (KKM) were 18 students, with a percentage of 65%, while students who received scores below as many as 12 students with a percentage of 35%. If you look at the data for each aspect, it can be concluded that there are still many students who only have enough mastery in terms of dhikr and pray after prayer. While those who reach the level of mastering well are the aspects of reading the Surah Al-Fatihah. The conclusion is that the Ability, Practicing of Reading and Movement of Prayer is interesting and enthusiastic so that through audio-visual media can be improved by audio-visual media.
PEMANFAATAN ALAM SEKITAR SEBAGAI SUMBER BELAJAR MATA PELAJARAN IPA DI MADRASAH IBTIDAIYAH
Authors: Fauzi Fauzi 
Published: November 2020

Abstrak
Tujuan dari penelitian ini adalah : Mendiskripsikan pemanfaatan alam sekitar sebagai sumber belajar mata pelajaran IPA. Untuk mendalami hal ini dilakukan penelitian dengan menggunakan metode pendekatan kualitatif. Dalam hal ini yang dijadikan sebagai Subyek adalah salah satu pendidk yang pengampu mata pelajaran yang menjadi guru kelas di kelas V, jumlah peserta didik sebanyak 28 murid. Metode yang digunakan dalam pengumpulan data yaitu metode observasi, dokumentasi serta wawancara. Untuk melengkapi keakuratan penelitian dan Keabsahan data perlu menggunakan metode dan teknik-teknik penelitian supaya mendapatkan hasil yang maksimal. Hasil yang didapat dari penelitian adalah: Pemanfaatan alam sekitar merupakan wahana yang dapat dijadikan sumber belajar yang dilakukan dalam bentuk variasi dan menyenangkan pada saat proses pembelajaran berlangsung baik di kelas maupun di luar kelas. Taman sekolah, kebun, dan sawah yang ada disekitar dapat dimanfaatkan sebagai sumber belajar yang menarik dan menyenangkan. Dalam pelaksanaan penggunaan pemanfaatan alam sekitar sebagai sumber belajar terdapat kendala-kendala diantara kurangnya kemampuan seorang pendidik dalam mengkondisikan peserta didik, membutuhkan waktu yang tidak sedikit dalam proses pelaksanaannya, peserta didik merasa kebingungan dalam mereviw dari hasil kegiatan, dan sumber belajar yang kurang mewadahi.
DONGENG MELATIH KEMAHIRAN ANAK MENULIS DONGENG MELALUI IMAJINASI
Authors: Prasetyo Aldi 
Published: November 2020

ABSTRACT
One of the important skills in language learning is writing. Writing skills, need to be familiarized with children, such as fairy tale writing skills. One way to teach it is a fun activity, which is by linking writing with children’s habit’s, which is to teach imagine. This study aims to analyze the results of the implementation of the design of learning to write fairy tales through imagination activities. The method used is descriptive qualitative. The subject is the fourth grade students of MI Muhamadiyah Beji with a total of 14 students. The result showed that 92.85% of the 14 student were able to create fairy tales through the imaginations, and 7.15% of students were unable to write them in writing because they did not follow the learning well. This activity is also able to explore children who have the potential to write.
Keywords: Indonesian Language, Writing Fairy Tales, Imagination.

ABSTRAK
Salah satu ketrampilan penting dalam pembelajaran bahasa ialah menulis. Ketrampilan Menulis, perlu dibiasakan pada anak, seperti ketrampilan menulis dongeng. Salah satu cara mengajarkannya ialah dengan kegiatan yang menyenangkan, yaitu dengan menghubungkan antara menulis dengan kebiasaan anak, yaitu berimajinasi. Penelitian ini bertujuan menganalisis hasil implementasi desain pembelajaran menulis dongeng melalui kegiatan berimajinasi. Metode yang digunakan ialah kualitatif deskriptif. Adapun subjeknya ialah siswa kelas IV MI Muhamadiayah Beji yang berjumlah 14 siswa. Hasil penelitian menunjukan bahwa 92.85% dari 14 siswa mampu membuat dongeng dengan melalui pancingan-pancingan imajinasi dan 7.15% siswa tidak mampu menuangkannya dalam bentuk tulis dikarenakan tidak mengikuti pembelajaran dengan baik. Kegiatan ini pula mampu menggali anak-anak yang mempunyai potensi menulis.
Kata kunci: Bahasa Indonesia, Menulis Dongeng, Imajinasi.
PEMBELAJARAN KREATIF MENULIS PUISI DENGAN MEDIA GAMBAR DI MI MA’ARIF NU I KALIWANGI
Authors: Muslimah  
Published: November 2020

Writing activities are essentially not only to give birth to a thought and a feeling, but also a disclosure of knowledge ideas and the life experience of a person in writing language.
The study used a qualitative approach with case study techniques. With the research subject grade V students MI ma'arif NU 1 Kaliwangi. Data collection techniques with interviews, observations, and documentation. Analytics Data uses the Miles and Huberman model.
Results showed (a) mature planning before the process of dissection (b) the implementation of creative learning with the image media assisted by the LCD, and Worksheet (c) Self-reliance assessment techniques with direct observation, and system point, (d) The lack of introductory media such as dictionaries changed basic barriers.
PENGGUNAAN MEDIA PERMAINAN CONGKLAK DALAM PEMBELAJARAN MATEMATIKA MATERI KPK DI KELAS IV
Authors: Aji Madia Abdurrahman  
Published: November 2020

According to Trianto, one of the main problems in learning mathematics in schools today is the low absorption of students. The way that can be used to overcome these problems is by using media in learning mathematics. From the results of writing conducted by Luh Made Suriwati, et al, it was found that learning with the help of visual media is more effective in improving student learning outcomes compared to conventional learning methods. One of the media that can be used in learning mathematics is Congklak game media.
This type of writing is action research aimed at developing an action plan to improve what is being done now. This writing is descriptive writing, where this writing is writing that really only describes what is contained or occurs in a particular scene, field, or region, namely SD N 1 Toyareka. This writing uses data collection techniques in the form of interviews, observation and documentation while the technical analysis of data uses data reduction, data presentation and data conclusion. The purpose of this writing is to describe the use of Congklak game media in learning mathematics in class IV and the use of Congklak game resources in instilling student character.
The results of the writing show that the Congklak media can be used in learning Mathematics of Multiples Small Guilds. Where in the use of the media, the authors modify the game board by giving writing numbers in each hole of the board. Through the use of these media students can actively and enthusiastically participate in chases that have an impact on improving student learning outcomes. In addition, through the use of the Congklak game media can help teachers to convey the concept of Multiple Small Guilds (KPK) easily and at the same time be more acceptable to students. Through the use of congklak game media can also instill the character of students' curiosity. Keywords
SENSE SEARCHING AND LINGUISTIC CREATIVITY IN NOMINATION PROCESSES IN THE SPHERE OF NEW INFORMATION TECHNOLOGIES
Authors: Богданова Светлана Юрьевна , Карыпкина Юлия Николаевна 
Published: November 2020

В статье анализируются факторы, влияющие на выбор языковых средств номинации объектов и действий в сфере «новые информационные технологии», а также смысловые ограничения, налагаемые этимологией слова, которые необходимо учитывать в процессе лингво-креативной деятельности. В условиях технологического прогресса естественный язык использует все внутренние резервы для обеспечения коммуникации между людьми. В процессе акта номинации определяются связи между тремя категориями различной природы, к которым относятся непосредственно элемент действительности, его мыслительный образ, существующий в сознании человека, и лексическая единица, фиксирующая данный образ в системе языка. Основным концептуальным механизмом номинации в анализируемой сфере является развитие смыслов, под которые подбираются или даже создаются слова. На примере номинативного поля сервиса Twitter продемонстрированы концептуальные механизмы, лежащие в основе словообразовательных моделей, применяемых в данной сфере. К данным механизмам относятся «концептуальная деривация», подразумевающая процесс рекомбинации смыслов, при которой новые концепты формируются на базе первичных, уже существовавших в концептуальной системе человека, и «концептуальная интеграция», обеспечивающая развитие языка и реализацию им ведущей функции передачи разнообразных смыслов при ограниченном наборе языковых средств. В сфере «новые информационные технологии» происходит развитие значений репрезентирующих ее слов, их специализация и закрепление в определенных позициях в грамматической структуре высказываний.
The article examines both the factors which influence the choice of the language means for the nomination of objects in the sphere «New Information Technologies» and semantic restrictions imposed by the «intrinsic form of a word» (or etymology) which should be taken into consideration in the process of linguocreative activity. In the situation of technological progress a human language uses all the internal resources to ensure communication between people. In nomination act the ties between three categories of different nature are identified. Those three categories comprise an element of real life, its mental image, and a lexical unit that fixes the image in the language system. The basic conceptual mechanism of nomination can be defined as the advancement of meanings for which appropriate words are chosen or even created. The conceptual mechanisms that underline the word-formation models with the reference to the nominative field of the Twitter service are illustrated. These mechanisms include «conceptual derivation» and «conceptual integration». Conceptual derivation implies the process of recombination of meanings already existing in a language. Conceptual integration guarantees both continual development of a language system and its implementation of the primary function of transmitting diverse meanings with a limited set of language resources.
THE REFERENTIAL POTENTIAL OF PERSON NAMES IN DIFFERENT-TYPE STATEMENTS IN ENGLISH AND TATAR LANGUAGES
Authors: Ибрагимова Эльмира Рафаилевна 
Published: November 2020

В рамках данной статьи рассматриваются особенности референциального статуса наименований лица, функционирующих с наибольшей частотой в предложениях различных логико-семантических типов в английском и татарском языках. Актуальность темы определяется незначительной степенью изученности референциального потенциала наименований лица в различных типах предложений, а также особенностей референциального статуса наименований лица в зависимости от выполняемой ими синтаксической функции, особенно в плане сопоставления двух разноструктурных языков. Целью статьи является исследование соотнесенности референциального потенциала наименований лица с реализацией ими различных синтаксических функций в высказываниях разных типов. Задачей статьи является анализ четырех типов предложений (экзистенции, идентификации, предикации, номинации) татарского и английского языков, отличающихся наиболее высокой частотой функционирования наименований лица, с целью определения их типичных референциальных значений. Объектом исследования выступают высказывания из национальных лингвистических корпусов татарского и английского языков, включающие существительные заявленной семантики. В статье использованы методы компонентного, дистрибутивного анализа. Данная работа выполнена в русле исследований пространственной референции Е. В. Падучевой и Н. Д. Арутюновой. Установлено, что наименования лица обладают разным референтным значением в зависимости от типа выражаемых в предложении отношений - от нереферентного значения в предложениях бытийности до конкретно референциального в предложениях, выражающих отношения идентификации в обоих языках.
The article is devoted to the analysis of referential status of person names in different-type English and Tatar statements. The relevance of the topic is determined by the insufficient knowledge level of the person names referential potential, the dependence of their referential potential on the statement types and their syntactic functions in those different-types statements especially in comparative terms. The purpose of the article is to investigate the dependence of person’s name attributive on its possibilities of implementing various syntactic functions in a statement. The task is to conduct an appropriate analysis of four statement types (existence, identification, predication, nomination) in English and Tatar languages with frequent use of person names in order to determine typical referential meanings. The study object are statements from Russian and English linguistic corpus including the nouns of the declared semantics. The article uses the methods of component and distribution analysis. This article is done in line with the researches of spatial reference carried by E. V. Paducheva and N. D. Harutyunova. It’s found out that person names possess different referential status depending on the statement type - from a noun without any reference to person names with specifically referential status
TRAINING SESSIONS ON «HISTORY» IN GAME FORM OF A COURT SESSION AS A METHOD OF INCREASING THE COGNITIVE ACTIVITY OF LAW STUDENTS
Authors: Пфаненштиль Надежда Георгиевна 
Published: November 2020

В данной статье подчеркивается важность использования в современном учебном процессе инновационных форм преподавания и особенное их значение в организации обучения в юридическом вузе. Подробно описывается механизм проведения учебного занятия по дисциплине «История» в игровой форме судебного заседания «Суд над Иваном Грозным» и анализируется его значение как метода повышения познавательной активности студентов. Перечисляются главные цели, организаторы, условия проведения деловой игры, а также основные этапы и ход «судебного заседания». Характеризуется основной состав участников и подробно описываются функции и обязанности каждого игрока в ходе подготовки, организации и проведения мероприятия. Формулируется общее значение деловой игры и перечисляются основные компетенции, умения и навыки, развитие которых она позволяет выявить и оценить. Данная игра позволяет сформировать у студентов комплексный подход к изучению и оценке исторических событий, явлений и деятелей, развивает способность к обобщению, самостоятельному анализу научной (и иной) информации, коммуникативные навыки, а также мотивацию к учебной деятельности и познавательный интерес к историческому наследию России.
This article emphasizes the importance of using innovative forms of teaching in the modern educational process and their special significance in the organization of training in law schools. It analyzes the mechanism of conducting a training session on the discipline «History» in the game form of the court session «Lawsuit against Ivan the Terrible» is described in detail and its significance as a method of increasing the cognitive activity of students; lists the main goals, organizers, conditions of the business game, as well as the main stages and progress of the «court session»; describes the main structure of participants and describes in detail the functions and responsibilities of each «player» when preparing, organizing and holding an event. The paper also describes the general meaning of the business game and the main competencies, skills and abilities that it helps to identify and evaluate. This game allows students to form a comprehensive approach to the study and assessment of historical events, phenomena and figures, develops the ability to generalize, independent analysis of scientific (and other) information, communication skills, as well as motivation for educational activities and cognitive interest in the historical heritage of Russia.
The M Supergiant High-mass X-Ray Binary 4U 1954+31
Authors: Hinkle Kenneth H. , Lebzelter Thomas , Fekel Francis C. , Straniero Oscar , Joyce Richard R. , Prato Lisa , Karnath Nicole , Habel Nolan 
Published: November 2020

Abstract
The X-ray binary 4U 1954+31 has been classified as a low-mass X-ray binary containing an M giant and a neutron star (NS). It has also been included in the rare class of X-ray symbiotic binaries. The Gaia parallax, infrared colors, spectral type, abundances, and orbital properties of the M star demonstrate that the cool star in this system is not a low-mass giant but a high-mass M supergiant. Thus, 4U 1954+31 is a high-mass X-ray binary (HMXB) containing a late-type supergiant. It is the only known binary system of this type. The mass of the M I is

M
⊙ giving an age of this system in the range 12–50 Myr with the NS no more than 43 Myr old. The spin period of the NS is one of the longest known, 5 hr. The existence of M I plus NS binary systems is in accord with stellar evolution theory, with this system a more evolved member of the HMXB population.
Scaling Laws for Dynamic Solar Loops
Authors: Bradshaw Stephen J. , Emslie A. Gordon 
Published: November 2020

Abstract
The scaling laws that relate the peak temperature T

M
and volumetric heating rate E

H
to the pressure P and length L for static coronal loops were established over 40 yr ago; they have proved to be of immense value in a wide range of studies. Here we extend these scaling laws to dynamic loops, where enthalpy flux becomes important to the energy balance, and study impulsive heating/filling characterized by upward enthalpy flows. We show that for collision-dominated thermal conduction, the functional dependencies of the scaling laws are the same as for the static case, when the radiative losses scale as T
−1/2, but with a different constant of proportionality that depends on the Mach number M of the flow. The dependence on the Mach number is such that the scaling laws for low to moderate Mach number flows are almost indistinguishable from the static case. When thermal conduction is limited by turbulent processes, however, the much weaker dependence of the scattering mean free path (and hence thermal conduction coefficient) on temperature leads to a limiting Mach number for return enthalpy fluxes driven by thermal conduction between the corona and chromosphere.