bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Does Diabetes Impair Penile Tissues during Erectile Dysfunction?
Authors: Wu Yi-Xing , Yang Chun-Tao , Li Na , Zheng Xue , Li Xiang , Zhang Hui , Shen Jie 
Published: May 2020

Background:
Erectile dysfunction (ED) is a significant but underestimated complication
during diabetes mellitus (DM). Currently, few special treatments are available clinically due to the lack
of specific therapeutic targets. Genomic analysis can be helpful to find potential targets. In this study,
the gene expression under diabetic ED condition was analyzed using a gene array, and the significance
of the outcomes was evaluated through clinical data.

Methods:
The expressions of 15923 genes were analyzed using R software. Differential expression
genes (DEGs) were identified through the constructed volcano plot. The function enrichment of Gene
Ontology (GO) and KEGG was screened with the DAVID online tool. The interaction between these
DEGs was revealed through constructing a protein-protein interaction network and the hub genes were
uncovered using the STRING and Cytoscape tool. Lastly, the data of diabetic ED patients were applied
to verify the bioinformatics findings.

Results:
The study showed that 75 genes in the rat penile tissues were upregulated, while 97 genes
were downregulated on the diabetic ED condition. These genes were mainly involved in extracellular
matrix composition, collagen fibril organization, as well as protein digestion & absorption. Additionally,
insulin-related signaling pathways were affected. The clinical analysis indicated that insulin resistance
was associated with the diabetic ED severity. Notably, the bioinformatics analysis also suggested
that ferroptosis pathway was probably activated under the diabetic ED condition.

Conclusion:
The impaired protein synthesis induced by deficient insulin signaling is an important
cause of the diabetic ED. The improvement of protein synthesis through restoring insulin function may
be potentially useful for diabetic ED therapy.
Scorpion Toxin-potassium Channel Interaction Law and its Applications
Authors: Zuo Zheng , Chen Zongyun , Cao Zhijian , Li Wenxin , Wu Yingliang 
Published: May 2020

:
The scorpion toxins are the largest potassium channel-blocking, peptide family. The
understanding of toxin binding interfaces is usually restricted to two classical binding interfaces:
one is the toxin α-helix motif, and the other is the antiparallel β-sheet motif. In this review, such
traditional knowledge has been updated by another two different binding interfaces: one is BmKTX
toxin using the turn motif between the α-helix and antiparallel β-sheet domains as the binding interface,
while the other is Tsκ toxin using the turn motif between the β-sheet in the N-terminal and α-
helix domains as the binding interface. Their interaction analysis indicated that the scarce, negatively
charged residues in the scorpion toxins played a critical role in orientating the toxin binding
interface. In view of the toxin, being negatively charged amino acids as a “binding interface regulator”,
the law of scorpion toxin-potassium channel interaction was proposed, that is, the polymorphism
of negatively charged residue distribution determines the diversity of toxin binding interfaces.
Such a law was used to develop the scorpion toxin-potassium channel recognition control
technique. According to this technique, three Kv1.3 channel-targeted peptides, using BmKTX as the
template, were designed with the distinct binding interfaces from that of BmKTX by modulating the
distribution of toxin, negatively charged residues. In view of the potassium channel as the common
target of different animal toxins, the proposed law was also shown to adjust the binding interfaces
of other animal toxins. The toxin-potassium channel interaction law would strongly accelerate the
research and development of different potassium channel-blocking animal toxins in the future.
The Economics of Rotating Savings and Credit Associations (ROSCAs) and Poverty in Indonesia
Authors: Kharisma Bayu , Remi Sutyastie Soemitro , Hadiyanto Ferry , Dwi Saputra Andhika 
Published: June 2020

Abstract: Arisan or Rotating Savings and Credit Associations (ROSCAs) constitute one of the most commonly found informal financial institutions in the developing world. This study aims to analyze the effect of Rotating Savings And Credit Associations (ROSCAs) on poverty in Indonesia using panel data sourced from the fourth and fifth wave of the Family Life Survey (IFLS). This study used a conditional logit or fixed effect logit to see the effect of Rotating Savings and Credit Associations (ROSCAs) participation and control variables, which include individual, household, and community characteristics on poverty variables that are binary or categorized. The results showed that Rotating Savings and Credit Associations (ROSCAs) participation can reduce poverty. Meanwhile, this study shows that women who participate in Rotating Savings and Credit Associations (ROSCAs) can reduce poverty significantly. Keywords: poverty, ROSCAs, IFLS, conditional logit Ekonomi Arisan dan Kemiskinan di Indonesia Abstrak: Arisan atau Rotating Savings and Credit Associations (ROSCAs) merupakan salah satu lembaga keuangan informal paling umum yang terdapat di negara berkembang. Penelitian ini bertujuan untuk melihat pengaruh arisan (ROSCAs) terhadap kemiskinan di Indonesia dengan menggunakan data panel yang bersumber dari Indonesia Family Life Survey (IFLS) gelombang keempat dan kelima. Metodologi yang digunakan dalam penelitian ini adalah Conditional Logit atau Fixed Effect Logit untuk melihat pengaruh variabel partisipasi arisan dan variabel kontrol yang meliputi karakteristik individu, rumah tangga, dan komunitas terhadap variabel kemiskinan yang bersifat biner atau kategori. Hasil penelitian ini menunjukkan bahwa partisipasi arisan dapat mengurangi kemiskinan. Selain itu, penelitian ini menunjukkan bahwa perempuan yang berpartisipasi dalam arisan dapat mengurangi kemiskinan secara signifikan. Kata kunci: Kemiskinan, arisan, IFLS, conditional logit
Determination of Entrepreneurship Education, Family Environment, and Self-Efficacy on Entrepreneurship Interest
Authors: Sugianingrat Ida Ayu Putu Widani , Wilyadewi Ida I Dewa Ayu Yayati , Sarmawa I Wayan Gde 
Published: June 2020

Abstract: This study aims to study the effect of entrepreneurship education, work environment, and self-efficacy on student interest in entrepreneurship. This research was conducted on students of the Faculty of Economics, Hindu University of Indonesia in 2016 who were taking entrepreneurship courses totaling 270 students. The number of samples is determined based on the Slovin formula with an error of 10%. Based on these calculations, a total sample of 79 students was obtained. Determining students who become samples is done randomly. Data collection is done by conducting interviews directly with respondents, based on a pre-arranged questionnaire. The collected data is then tabulated, then processed using the SmartPLS 3.0 program. The results of the hypothesis testing show that entrepreneurship education and family environments have a significant positive effect on students' interest in entrepreneurship. Meanwhile, self-efficacy shows positive results but does not significantly influence the interests of students to become entrepreneurs.Keywords: entrepreneurship education, family environment, self-efficacy, entrepreneurial interest Pengaruh Pendidikan Kewirausahaan, Lingkungan Kerja, dan Efikasi Diri terhadap Minat Mahasiswa Berwirausaha Abstrak: Penelitian ini bertujuan untuk melakukan kajian pengaruh pendidikan kewirausahaan, lingkungan kerja, dan efikasi diri terhadap minat mahasiswa untuk berwirausaha. Penelitian ini dilakukan pada mahasiswa Fakultas Ekonomi Universitas Hindu Indonesia angkatan tahun 2016 yang sedang mengambil mata kuliah kewirausahaan berjumlah 270 mahasiswa. Jumlah sampel penelitian ditentukan berdasarkan rumus Slovin dengan error 10%. Berdasarkan perhitungan tersebut diperoleh jumlah sampel sebanyak 79 mahasiswa. Penentuan mahasiswa yang menjadi sampel penelitian dilakukan secara acak. Pengumpulan data dilakukan dengan melakukan wawancara langsung kepada responden, berdasar pada kuesioner yang telah dipersiapkan. Data yang telah terkumpul selanjutnya dilakukan tabulasi, kemudian diolah dengan mempergunakan program SmartPLS 3.0. Hasil pengujian hipotesis menunjukkan pendidikan kewirausahaan dan lingkungan keluarga berpengaruh secara positif signifikan terhadap minat mahasiswa untuk berwirausaha. Sedangkan, efikasi diri menunjukkan hasil yang positif, tetapi tidak signifikan berpengaruh terhadap minat mahasiswa untuk berwirausaha. Kata Kunci: Pendidikan kewirausahaan, Lingkungan keluarga, Efikasi diri, Minat berwirausaha
Wearable Detection Systems for Epileptic Seizure: A review
Authors: Alwindawi Alla Fikrat , UÇAN Osman Nuri , Morad Ameer Hussein 
Published: May 2020

The seizure epilepsy is risky because it happens randomly and leads to death in some cases. The standard epileptic seizures monitoring system involves video/EEG (electro-encephalography), which bothers the patient, as EEG electrodes are attached to the patient’s head.
Seriously, helping or alerting the patient before the seizure is one of the issue that attracts the researchers and designers attention. So that there are spectrums of portable seizure detection systems available in markets which are based on non-EEG signal.
The aim of this article is to provide a literature survey for the latest articles that cover many issues in the field of designing portable real-time seizure detection that includes the use of multiple body signals, new algorithm methods, and detection devices that are commercially available.
As a result, the reviewing process shows that there are many research articles that have covered wearable seizure detection systems that based on body signals. The more effective monitoring and detection seizure system is the system that uses multi-body signals, is highly comfortable and has low power consumption.
The Effect of Government Consumption and Government Investment as Intervening Variables to Growth in Indonesia
Authors: Suparjito Suparjito , Sarungu Julianus Johnny , Soesilo Albertus Magnus , Samudro Bhimo Rizky , Hasanah Erni Ummi 
Published: May 2020

Fiscal policy and monetary policy are the two macroeconomic policies used by the government and monetary authorities in order to create a stable economy. The budget deficit policy is one form of fiscal policy implemented by the government in order to realize a high level of economic growth, a controlled inflation rate and open up new job opportunities to reduce unemployment. The impact of the implementation of the budget deficit policy on the level of economic growth is a long debate. Neoclassical groups argue that the implementation of budget deficit policies is detrimental to the economy, as it lowers the rate of economic growth. Keynesian groups argue that the implementation of the budget deficit policy is very good for the economy, because it triggers the rate of economic growth by increasing the number of demand for goods and services through increased government spending. While the Richardian people argue that the implementation of budget deficit policy has no effect on the economy. The data used in this study is data from 1981-2014 which consists of budget deficit, government consumption, government investment and economic growth rate. The method of analysis in this research is using Partial Least Square-Path Modeling (PLS-PM) approach with SMART-PLS analysis tool which aims to analyze the direct and indirect influence of the implementation of budget deficit policy toward the level of economic growth through government consumption and government investment. The results show that the implementation of the budget deficit policy can increase economic growth through increased government investment spending. Keywords: budget deficits, government investment, government consumption, growth.
Use of Artificial Intelligence & Machine Learning with Deep Learning for Glaucoma Detection in Human Eyes & its Real Time Hardware Implementation
Authors: Jipeng Tian , P. Suma , Manjunath T. C. 
Published: May 2020

In this paper, a brief introduction to AI, ML and the Eye w.r.t. Deep Learning for Glaucoma Detection and Hardware Implementation is being presented. The result is the outcome of the Post-Graduate project work of the student that is going to be carried out in the second year of the course & this work is just the synopsis that is being framed for the carrying out of the detection of glaucoma disease.
Short-term Power Load Forecast of an Electrically Heated House in St. John’s, Newfoundland, Canada
Authors: Marma Hla U May , Iqbal M. Tariq , Seary Christopher Thomas 
Published: May 2020

A highly efficient deep learning method for short-term power load forecasting has been developed recently. It is a challenge to improve forecasting accuracy, as power consumption data at the individual household level is erratic for variable weather conditions and random human behaviour. In this paper, a robust short-term power load forecasting method is developed based on a Bidirectional long short-term memory (Bi-LSTM) and long short-term memory (LSTM) neural network with stationary wavelet transform (SWT). The actual power load data is classified according to seasonal power usage behaviour. For each load classification, short-term power load forecasting is performed using the developed method. A set of lagged power load data vectors is generated from the historical power load data, and SWT decomposes the vectors into sub-components. A Bi-LSTM neural network layer extracts features from the sub-components, and an LSTM layer is used to forecast the power load from each extracted feature. A dropout layer with fixed probability is added after the Bi-LSTM and LSTM layers to bolster the forecasting accuracy. In order to evaluate the accuracy of the proposed model, it is compared against other developed short-term load forecasting models which are subjected to two seasonal load classifications.
Smoked African Catfish (Clarias gariepinus) Sampled from Two Markets and Occurrence of Microbes
Authors: Daramola John Abiodun , Kester C. T. , Allo O. O. 
Published: May 2020

The study was carried out to assess some microbiological qualities of smoked African catfish, Clarias gariepinus retailed in Sango and Ota markets in Ogun state, Nigeria. Six smoked fish retailers were randomly selected from the markets and 36 fish samples were collected. The samples of smoked catfish were assessed weekly for a period of six weeks for microbiological parameters such as Total plate count (TPC), Total coliforms count (TCC), Staphylococcus count and mould count. In this study, the microbial load of the smoked Clarias gariepinus samples retailed in the two study sites increased weekly during the period of storage. TPC increased from 4.75±0.014 log10 CFU/g for smoked samples from Ota market, retailer 1 (OMR1) in week 0 to 5.11 ±0.021 log10 CFU/g for samples from Ota market, retailer 3 (OMR3) in week 5. TCC ranged from 1.47±0.001 log10 CFU/g to 2.43±0.049 log10 CFU/g; Staphylococcus from 2.15±0.070 log10 (CFU/g) to 2.66±0.014 log10 (CFU/g) and 1.82 ±0.070 log10 CFU/g to 2.92±0.071 log10 CFU/g for mould counts. The smoked Clarias gariepinus from the markets could not keep well till the 6th week. Hence, it can be inferred that smoked catfish with moisture content of about 10% or less will have a shelf life of about 4 - 5 weeks under ambient storage conditions before the effect of spoilage microorganisms.
A Comparative in Vivo Study on Bambusa Polymorpha, Mentha Piperita and Clitoria Ternatea as Alternative Anxiolytic
Authors: Tunna Tasnuva , Akter Mst. Sharmin , Parvin Mahmuda , Jilhaz Md. , Jahan Shamema , ISM Zaidul 
Published: May 2020

This is a continuation of our “Stress Management with Herbal Alternatives” project whereby we are testing traditionally used herbs to scientifically establish their efficacy as anxiolytics for the 1st time. For the current study Bamboo leaf tea, Mint leaf tea and Clitoral bush petal tea were compared for their anxiolytic potency. Male Swiss albino mice were used to test on Open Field test (OFT) and Elevated Plus Maze (EPM) anxiety model. Diazepam (at the dose of 0.25mg/kg body weight) was used as standard and Bangladeshi indigenous bamboo aka Bambusa polymorpha or Bamboo, Mentha piperita or Mint and Clitoria ternatea or Clitoral Bush (at doses of 1g/kg body weight) were the sample. The control group had no intervention. For OFT we tested line crossing, time spent in center, time spent in thigmotaxis and for EPM we measured the number of entry in open and closed hands, time spent in the open and closed hands. Parameters such as rearing, grooming, urination and defecation were also monitored for both tests.The trial results showed Clitoral bush and Mint leaves to have greater anxiolytic activity than Bamboo and Diazepam. Bamboo and Clitoral Bush helped in weight loss, wherelse Diazepam caused weight gain. Based on all criteria, Clitoral bush tea showed highest potential to reduce stress as well as stress related obesity. Results were followed by mint, diazepam and bamboo respectively in their potency for anxiolytic effect.
Origin of Life’s Chirality
Authors: Deans Michael 
Published: May 2020

The phase transition at 72K in ice XIc accommodating water molecules’ irregular tetrahedral shape I discovered in 1967 restores the confidence in science measuring c challenged. Forming in polar pools of N2 during a primordial ice-age, fluctuating temperatures released latent energy as λ ~4µ laser light. Multiple reflection polarized it and deoxynucleotides on tropical water surfaces were polymerized, creating chiral DNA, uniquely explaining life’s origin.
‘Transport DNAs’ sharing tRNA’s H-bond-lined pores concentrated life’s ingredients in coacervates. Replicate tDNAs originated life. DNA’s stability makes it life’s likely precursor. ‘Differentiation DNAs’ selecting tDNAs control cell diet and tissue specialization. Nine pathways deploying trace elements as carriers control metabolism. Mutant tDNAs and dietary deficits account for morbidity.
‘Minion’ DNA/oligopeptide complexes optimize chromosomes replication. They function as biological clocks, chips-in-the-brain and nuclear fusion reactors. Minion logic reinterprets 20th century scientific axioms. Resonant cavities coupling chemical to mechanical energy efficiently.
Case Report : Multiple Stress Fractures (hamate, triquetrum, 2nd, 3rd, and 4th Metacarpal bones) in an Amateur Tennis Player
Authors: AlShareef Hatim Mohammed A. , Alshareef Alhusain Mohammad , AlKaff Mohammed Hussein 
Published: May 2020

Background: upper extremity stress fractures are infrequent events in tennis sport. According to our literature, we have only identified 6 case reports of upper limb stress fractures among amateur or professional tennis players. To the best of our knowledge, this is the only case report where stress fractures occur in: hamate, triquetrum, 2nd, 4th, and 5th metacarpal bones simultaneously.
Case presentation: 27 years old lady, presented with acute burning pain at the base of her right thumb. There was not a history of direct trauma. Her symptoms start to appear after 3 days of playing tennis. Physical examination was negative for tenderness, swelling and erythema. The rheumatoid factor was elevated (20.3 iu/ml). the diagnosis of multiple stress fractures was made by the suggestive MRI findings.
Conclusion: Although stress fractures of the upper limbs are not common, it is of a great value to keep the clinical suspicion high towards it. Especially in amateur or professional athletes with persistent or worsening symptoms. The best modality to confirm such fractures is MRI.
New Trends in Medical Education During and Post COVID-19 Pandemic
Authors: Potaliya Pushpa , Ghatak Surajit 
Published: May 2020

This sudden emerged crisis of COVID-19 pandemic has forced the medical units globally with practical and logistical trial and apprehensions for patient wellbeing. In addition, it has affected medical education by forcing them to stay away from the institutes for preventing potential spread of virus. Mean time conventional classroom teaching and in-hand experience in training are affected. This short communication discusses the current transformation in medical education by adoption of newer trends, describes how COVID-19 may affect the standard curriculum and learning milieus, and scouts impending consequences in Post COVID-19 era for the future of medical education.
Temuan Botol Dari Pulau Enggano. Analisis Sejarah dan Teknologi Pembuatan
Authors: Novita Aryandini , Alnoza Muhamad , Prasetyo Sigit Eko 
Published: May 2020

Enggano island is one of the foremost islands of the Republic of Indonesia in the western part of Sumatera. Geologically, this island has never been integrated with the sumateran mainland, in contrast to the upper islands such as, Nias and Mentawai, thus, the only access to this island is from the sea. From the result of study in the field, it is known that this island was once used as a coconut plantation land by the Dutch, and controlled by the Japanese since 1943. During Japanese period, the island was focused on being a naval base as evidenced by the existence of defense buildings such as pillboxes and bunkers on the Enggano coast. One of the archeological findings that is interesting and has never been studied is the bottle. From the results of the analysis, the findings of the bottle have a different form, origin, and technology. The technology of making bottles has developed from time to time. This technology is known from the traces of its manufacture, namely the vertical lines and bubbles contained in the bottle. From the results of the reading of the inscriptions and bottle comparisons, it is known that the bottles are from Europe and Asia, and contain a type of alcoholic beverage.
Desarrollo de objetos de aprendizaje para el aprendizaje de las estructuras de datos
Authors: Aguilar Juárez Irene , Alejo Saldívar Víctor Alfonso , Ayala de la Vega Joel 
Published: May 2020

En este trabajo se describe el desarrollo y evaluación de varios objetos de aprendizaje que se usarán como componentes de un curso MOOC (Masive Open On Line Course) en el marco de trabajo de las Comunidades Digitales de Producción gestionadas por la red CODAES (Comunidades Digitales para el Aprendizaje en Educación Superior) en México. Los materiales surgen ante la necesidad de proveer a los alumnos de nivel superior de profesiones afines a la computación diferentes medios de aprendizaje sobre temas complejos y necesarios en su formación. Los índices de reprobación actuales muestran que las técnicas de enseñanza tradicionales no han resultado efectivas para lograr el aprendizaje de algunos tópicos como la programación; los datos confirman que esta competencia es difícil de adquirir para los estudiantes por lo que es necesario buscar alternativas para el aprendizaje de los alumnos.
El equipo de investigación desarrolló como parte central de la preparación del curso MOOC de estructuras de datos varios objetos de aprendizaje que abordaron los tópicos relacionados al uso de los árboles binarios. La evaluación de los alumnos que los usaron fue favorable en los aspectos de: percepción de utilidad de los materiales, la pertinencia de las actividades, la facilidad de las tareas encomendadas y sobre la claridad de indicaciones y cuestionamientos. Los resultados de esta evaluación permiten considerar que los objetos de aprendizaje desarrollados en esta fase de trabajo serán bien recibidos en el curso MOOC del cual serán parte.