bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Study of Serum Iron Profile in Patients with Chronic Kidney Disease
Authors: Shastry Indira , Belurkar Sushma 
Published: November 2020

Background: Even though anemia and iron deficiency can increase the morbidity and mortality in patients with chronic kidney disease (CKD), an iron overload can be dangerous as well.
Aim: Identify the number of CKD patients with iron deficiency, iron overload, acute phase reaction and anemia of chronic disease in a tertiary care hospital.
Material and methods: The study was conducted in Kasturba medical college, Manipal. 154 patients with CKD were selected for the study irrespective of their treatment status with hematinics and/or erythropoietin.
Results: The mean total serum iron levels were 61μg/dl, Total Iron Binding Capacity (TIBC) 216.43 μg/dl, serum ferritin 539.68 μg/dl, and transferrin saturation of 32.18% respectively. When the serum iron profile of individuals was analyzed, majority (54.25%) of the patients were found to have acute phase reaction and most of them were in advanced stage of renal failure. Normal serum iron profile was found in 37.2% patients, iron overload in 2.2%, anemia of chronic disease in 5.3% and iron deficiency in 1% cases. These findings were statistically significant with the P value of 0.001.
Conclusion: Most common type of serum iron profile found in the study population was acute phase reaction (54%) and majority of them were in stage 5 renal failure. Hence, before beginning an iron therapy, all the patients with anemia in chronic kidney disease should be evaluated for body iron status to prevent iron overload.
Cytomorphological Analysis of Neoplastic Lesions of Neck Node with Special Reference to Lymphomas
Authors: Devi Junu 
Published: November 2020

BACKGROUND: Neoplastic lesions of lymph node in cervical region pose a diagnostic delima and very often cytological diagnosis proves invaluable. An early diagnosis of the lesions is essential for proper management. To assess the frequency distribution and cytological analysis of various neoplastic lesions of lymph node with special reference to the lymphoma.
MATERIAL AND METHODS: this is a cross-sectional study which provides analysis of 164 neoplastic lesions of lymph node out of 758 lymph node aspirate. Cytomorphological pattern and cellular detail are reviewed carefully and diagnosis were made. Histopathological and immunohistochemical correlation done wherever needed.
RESULTS: Out of 164 neoplasms 86.59% secondary neoplasms(61.27% SCC, 19.72% Adenocarcinoma,15.49% poorly differentiated carcinoma,0.70% undifferentiated carcinoma, 0.70% mucoepidermoid carcinoma, 0.70% papillary thyroid carcinoma,1.41% leukemic deposit),12.2% lymphoid neoplasms. M:F = 1.2:1. Diagnostic accuracy was calculated as 98.67%, and false positive rate 1.3%
CONCLUSION: fine needle aspiration cytology is invaluable in rapid diagnosis of lymph node neoplasms of cervical region however histological confirmation and immunohistochemical analysis is mandatory in certain tumors specially lymphomas, poorly and undifferentiated carcinoma for accurate diagnosis and proper management.
Immunohistochemical Study of CA 125 in Surface Epithelial Tumors of Ovary in Correlation with Serum Levels
Authors: Pillarisetty Karishma , Ravindra Savithri 
Published: November 2020

Background:
Ovarian carcinoma is the 4th leading cancer among women in India. Primary ovarian neoplasms exhibit a wide range of histopathological patterns and tumors with epithelial differentiation are most frequent. Among malignant tumors, most common histological type is serous adenocarcinoma whose diagnosis is established in advanced stages of disease in approximately 75% of patients.
The most widely used tumor marker in ovarian cancer, often considered “gold standard” is Cancer Antigen125. Cancer Antigen 125 is a high molecular weight glycoprotein which is raised in approximately 90% of patients with advanced epithelial ovarian cancer.

Methods:
A 2 year prospective study included 81 cases of ovarian neoplasms with surface epithelial differentiation. The specimens were fixed in 10% formalin, routinely processed. Sections of 4-5 microns thickness were obtained from the paraffin block and stained with Hematoxylin & Eosin. The tumors were categorised according to WHO classification. Immunohistochemical analysis of Cancer Antigen 125 was done in all malignant & borderline tumors.

Result:
A total of 81 cases were studied. There were 15 cases with elevated serum Cancer Antigen 125 levels. Of these 8 showed positive tissue expression. The sensitivity of serum Cancer Antigen 125 was 68.75% & its specificity was 93.8%.

Conclusion:
Serum Cancer Antigen 125 is elevated in ovarian tumors especially in malignant surface epithelial tumors & more commonly in serous cystadenocarcinoma. There was a good correlation between serum levels & tissue expression of Cancer Antigen 125.
Effects of Site of Blood Collection and Duration of Storage on Coagulation Factor V and Factor IX Levels in Fresh Frozen Plasma
Authors: R Loganathan , Kulkarni Rajendra G , Kar Rakhee , Abhishekh B , Basu Debdatta 
Published: November 2020

Background: As per Indian drugs and cosmetic act & rules 1945 (DCA), 1% or 4 units/month of all components should meet quality control parameter. Aims and objectives: 1.) To assess the level of clotting factors FV and FIX in FFP. 2.) To identify the association between clotting factors FV and FIX in FFP with its mode of collection and storage.
Methods: This is a Cross sectional study design done for a period of 20 months. The comparison of the levels of clotting factors such as V and IX between the blood group were carried out by using independent students’ one-way analysis of variance. All statistical analysis was carried out at 5% level of significance and p-value <0.05 were considered as significant. All statistical analysis was done using software IBM PASW statistics (SPSS) version 19.0.
Result: The present study was done at a south Indian tertiary care center from January 2016 to August 2017. Around 28,919 FFPs were assessed during this study period. On comparing factor levels between blood bank and camp site, there were no significant difference.
Conclusion: In our study, FV and FIX were maintained as per DGHS criteria.
Normoalbuminuric Diabetic Kidney Disease- Need for Renal Biopsy? An Autopsy Study on Western Indian Population
Authors: Paul Sonal , Gadgil Nitin M , Padmanabhan Anitha 
Published: November 2020

Introduction: Persistent albuminuria and glomerular filtration rate are considered as the gold standard for the diagnosis of Diabetic Nephropathy (DN).
Methods: In this autopsy study, we evaluated data from a cohort of 67 patients with Type 2 Diabetes Mellitus. We determined the histological prevalence of DN irrespective of the clinical manifestations of renal disease. Patients were stratified by proteinuria and estimated glomerular filtration rate(eGFR). The glomerular, interstitial and vascular lesions were scored as per the established histopathologic classification for DN.
Results: 55 of the 67 patients had clinical as well as histological lesions consistent with DN. 12 patients had histological lesions of DN at autopsy but no clinical evidence of proteinuria, including microalbuminuria in their lifetime.4 of these patients had maintained eGFR. There was no difference in the glomerular lesions in patients with normoalbuminuria regardless of the eGFR. However,50% of the patients with low eGFR showed presence of interstitial fibrosis and tubular atrophy while no interstitial lesions were noted in patients with normoalbuminuria and maintained eGFR. Significant amount of arteriosclerosis was noted in the normoalbuminuric low eGFR patients. Haematuria was significantly associated with proteinuric low GFR patients.
Conclusion: Histological evidence of DN may be seen even in the absence of clinical manifestations, suggesting that, in diabetic kidneys some amount of glomerular and tubulointerstitial damage has already occurred before the onset of proteinuria. Hence, there is a need for routine kidney biopsies in diabetic patients with normoalbuminuria. This will help in the timely diagnosis and appropriate management in the early stages of DN.
A Retrospective Study of Soft Tissue Tumors - Role of Histomorphology in Diagnosis
Authors: Damani Sagar Sanjay , Patil Soniya Anant , Ansari M H , Baste Balaji Devrao 
Published: November 2020

Background: The field of soft tissue tumors is vast and yet to be explored. The diagnosis of these tumors is always challenging for the pathologists. The overlap in the clinical and radiological features makes histopathology very crucial in their identification.

Methods: This is a retrospective study of soft tissue tumors over a period of 18 months from January 2014 to June 2015 conducted in the Department of Pathology. The gross specimens were fixed in 10% formalin and the slides were stained by Hematoxylin and Eosin. Immunohistochemistry was performed wherever necessary.

Result: A total of 235 soft tissue tumors were studied of which benign cases were 225 (95.75%), intermediate 04 (1.70%) and malignant 06 (2.55%). The tumors had a male preponderance, with majority in the third decade, predominantly occurring in the head neck region. Of a total of eleven categories of soft tissue tumors in our study, the adipocytic category was the most common followed by the nerve sheath and vascular tumors.

Conclusion: Molecular diagnosis have started to gain momentum in the field of soft tissue tumors, however histomorphology still remains the gold standard.
Updated research agenda for water, sanitation and antimicrobial resistance
Authors: Sano Daisuke , Louise Wester Astrid , Schmitt Heike , Amarasiri Mohan , Kirby Amy , Medlicott Kate , Roda Husman Ana Maria de 
Published: November 2020

Abstract
The emergence and spread of antimicrobial resistance (AMR), including clinically relevant antimicrobial-resistant bacteria, genetic resistance elements, and antibiotic residues, presents a significant threat to human health. Reducing the incidence of infection by improving water, sanitation, and hygiene (WASH) is one of five objectives in the World Health Organization's (WHO) Global Action Plan on AMR. In September 2019, WHO and the Health-Related Water Microbiology specialist group (HRWM-SG) of the International Water Association (IWA) organized its third workshop on AMR, focusing on the following three main issues: environmental pathways of AMR transmission, environmental surveillance, and removal from human waste. The workshop concluded that despite an increase in scientific evidence that the environment may play a significant role, especially in low-resource settings, the exact relative role of the environment is still unclear. Given many antibiotic-resistant bacteria (ARB) can be part of the normal gut flora, it can be assumed that for environmental transmission, the burden of fecal-oral transmission of AMR in a geographical area follows that of WASH-related infections. There are some uncertainties as to the potential for the propagation of particular resistance genes within wastewater treatment plants (WWTPs), but there is no doubt that the reduction in viable microbes (with or without resistance genes) available for transmission via the environment is one of the goals of human waste management. Although progress has been made in the past years with respect to quantifying environmental AMR transmission potential, still more data on the spread of environmental AMR within human communities is needed. Even though evidence on AMR in WWTPs has increased, the reduction in the emergence and spread of AMR by basic sanitation methods is yet unresolved. In order to contribute to the generation of harmonized One Health surveillance data, WHO has initiated an integrated One Health surveillance strategy that includes the environment. The main challenge lies in rolling it out globally including to the poorest regions.
This article has been made Open Access thanks to the generous support of a global network of libraries as part of the Knowledge Unlatched Select initiative.
Heterogeneity of Cash Markets at Physical Delivery Points and the Hedging Effectiveness of Agricultural Commodity Futures in India – Lessons for Contract Optimization.
Authors: Mansabdar Sanjay , Yaganti Hussain C 
Published: November 2020

Agricultural commodity futures in India are settled by physical delivery and the seller can choose the location of delivery from a list described in the contract specifications. Cash markets at these locations represent the deliverable basket for the futures contract and are the underlying assets for the delivery options granted to the seller by virtue of contract design. These cash markets are generally heterogenous. This paper studies the impact of heterogeneity of the underlying cash markets in different locations on the hedging effectiveness of the associated futures contract. The hedging effectiveness of cottonseed oilcake and soybean futures is regressed against several variables that represent heterogeneity of the underlying cash markets using ridge regression. We find that in general, the greater the heterogeneity, the poorer the hedging effectiveness of the contract. This paper is unique in that it provides a framework for guidance for contract designers at exchanges and regulators who will find this research useful in optimizing delivery specifications for agricultural futures contracts. This is especially important given the declining volumes in Indian agricultural commodity futures.
Evaluasi dan Implikasi Kebijakan Pemberantasan Kejahatan Perikanan di Indonesia 2014-2018
Authors: Karim Muhamad 
Published: November 2020

Kejahatan perikanan telah berlangsung sejak tahun 1970-an di Indonesia. Studi ini bertujuan (i) menganalisis kebijakan pemberantasan kejahatan perikanan di Indonesia; (ii) menganalisis dampak kebijakan pemberantasan kejahatan perikanan terhadap keberlanjutan sumber daya perikanan dan kesejahteraan nelayan, dan (iii) memberikan rumusan rekomendasi bagi pengelolaan sumber daya perikanan yang berkelanjutan dan mensejahterakan seluruh rakyat. Penelitian ini bersifat deskriptif-kualitatif dengan menggunakan data-data sekunder. Data-data tersebut diperoleh dari instansi terkait Badan Pusat Statistika, publikasi Kementerian Kelautan dan Perikanan Republik Indonesia, Bank Indonesia dan dokumen hasil penelitian relevan. Penelitian ini menggunakan metode deskriptif analisis dari kebijakan publik. Hasilnya disajikan dalam bentuk tabel, diagram, histogram, dan persentase yang kemudian diinterpretasikan. Penelitian ini menyimpulkan bahwa kebijakan pemberantasan kejahatan perikanan di Indonesia selama kurun waktu 2014-2018 belum berjalan secara optimal karena implementasi pada tataran nasional masih menimbulkan resistensi seperti dalam kasus pelarangan cantrang. Kebijakan ini juga berdampak positif terhadap keberlanjutan sumber daya ikan di Indonesia dan kesejahteraan nelayan. Meskipun, kejahatan perikanan masih sering terjadi seperti penangkapan ikan oleh kapal asing ilegal. Pasca 2019, kebijakan ini harus tetap dilanjutkan agar melindungi sumber daya ikan dan menjamin kedaulatan Indonesia atas sumber daya lautnya. Hasil studi ini merekomendasikan bahwa penanganan kasus kejahatan perikanan tidak selamanya dengan mekanisme pengadilan pidana semata, melainkan bisa juga dapat dilakukan melalui meknaisme non pengadilan yaitu mekanisme keadilan restoratif (restorative justice).
Anti-SAE1 Antibodies and Dermatomyositis: A Case Series of Three Patients
Authors: Wilson Claire , Roman Brandon , Ashack Kurt , Aronson Iris K 
Published: November 2020

To date, few patients with anti-SAE1 dermatomyositis (DM) have been described, and usually in large descriptive cohort studies including all DM subtypes. Thus, it is increasingly important to further describe this rare subtype to solidify cutaneous findings, associated symptoms, and potential therapeutic options. Herein, this case series describes three patients with anti-SAE1 DM with respect to their clinical and laboratory findings, and also their response to treatment. All three patients eventually presented with classic cutaneous manifestations of dermatomyositis, however, Case 2 presented initially with cutaneous manifestations not described in the literature. Furthermore, two patients presented with dysphagia, with Case 2 experiencing a life-threatening dysphagia not typically described in the literature. Two of three patients also presented with early signs of interstitial lung disease. Lastly, cutaneous disease was only responsive to immunosuppressants in one patient. Unfortunately, this observational case-series consisted of only three patients, limiting the generalizability of our results. However, this study provides further support of the recalcitrant nature of this DM subtype, and commonly affected extracutaneous systems including the gastrointestinal and pulmonary systems. Larger studies of this patient population are needed to further confirm our associated findings.
Endoscopic antegrade aqueductoplasty and stenting with panventricular catheter in management of trapped fourth ventricle in patients with inadequately functioning supratentorial shunt
Authors: Elsharkawy Ahmed Abdelaziz , Elatrozy Hytham 
Published: November 2020

Background:
Trapped fourth ventricle (TFV) usually develops as a complication of supratentorial ventricular CSF shunting, especially when hydrocephalus is caused by intraventricular hemorrhage and/or infection. This study aimed to assess the feasibility of endoscopic aqueduct stenting using a single refashioned shunt tube to treat cases presenting with both TFV and shunt malfunction.

Methods:
We retrospectively collected and analyzed data from patients presenting with TFV and supratentorial shunt malfunction who underwent endoscopic aqueduct stenting using a refashioned shunt tube. All cases were treated at our institution between January 2010 and July 2019. The surgical technique is described.

Results:
Eighteen patients were enrolled in our study. There were ten males and eight females. The mean age was 11.2 years (range = 1–33 years). Headache, nausea, and vomiting were the most common clinical presentations. The mean duration of follow-up was 22.1 months (range = 6–60 months). All cases showed clinical and radiological improvement after surgery.

Conclusion:
Endoscopic antegrade aqueductoplasty and stenting with the refashioned panventricular shunt catheter are an adequate treatment option for both TFV and supratentorial shunt malfuncion.
Characterization and Bioactivity Test of Pectin from Musa balbisiana Peel Extracted using Various Acid Solvents
Authors: Husnawati  , Astutik Ika Yuni , Ambarsari Laksmi 
Published: November 2020

Banana (Musaceaea) is one of the highest production fruits in Indonesia, which amounted to 7,162,685 tons in 2017. Banana peel waste produced can reach 40% of the total production of fresh bananas. Kepok banana peel contains a lot of nutrients and pectin. Pectin levels in banana peel ranged from 1.92% to 3.25% of dry weight. This study aims to characterize pectin from kepok banana peel (Musa balbisiana) extracted using nitric acid, citric acid, and HCl and screening potential of pectin bioactivity based on LC50 values. The highest pectin yield was obtained from extraction using pH 4 citrate buffer which was 3.68 ± 1.23%. In general, the characteristics of the best pectin from kepok banana peel are pectin extracted with HNO3 pH 4 with methoxyl degree 3.74 ± 0.34%, galacturonate content 87.64 ± 8.36%, and esterification degree 24.24 ± 0.098%. Based on the LC50 value the pectin extraction results can be classified into two, namely commercial pectin and pectin HCl pH 1.5 which is low bioactivity (LC50 > 100 ppm), and pH 4 HNO3 pectin and pH 4 citrate buffer pectin which has high bioactivity (LC50 ≤ 30 ppm).

Keywords: Cytotoxicity, galakturonat, kepok banana pectin, methoxyl
Antioxidant Status of Sprague-Dawley Female Rat with Curcuminoids Nanoparticles of Balittro Curcuma
Authors: Ambarsari Laksmi , Febrianti Riska , Purwakusumah Edy Djauhari 
Published: November 2020

Curcuma (Curcuma xanthorrhiza) is an Indonesian herbs plant with antioxidant activity. This research aimed to measure the increase of curcuminoids bioavailability through the effectivity of nanoparticle curcuminoids as an antioxidant for carbon tetrachloride (CCl4) induced rats. Nanoparticle curcuminoids were produced by homogenization-ultrasonication method showed results particle size of curcuminoids nanoparticle was 141.85±38.82 nm with polydispersity index was 0.233 and entrapment efficiency was 71%. During the treatment, the rat’s body weight was increased. Clinical symptoms of rats (behavior and feces) were normal. Nanoparticle curcuminoids can decrease malondialdehyde concentrations and increase peroxide, glutathione peroxide, and superoxide dismutase activity.

Keywords : antioxidant, curcuminoid, solid lipid nanoparticle, Curcuma.
DETERMINAN SISA LEBIH PEMBIAYAAN ANGGARAN (SILPA) KABUPATEN LOMBOK UTARA TAHUN 2009-2018
Authors: Agustiani Eka 
Published: November 2020

Analisis Determinan SILPA Kabupaten Lombok Utara 2009-2018 bertujuan untuk menganalisis pengaruh realisasi dana bagi hasil, realisasi dana alokasi khusus, dan realisasi dana alokasi umum terhadap Sisa Lebih Pembiayaan Anggaran (SILPA) Kabupaten Lombok Utara tahun 2009-2018.
Pengumpulan data dengan studi pustaka dan dokumentasi. Pendekatan kuantitatif melalui pengumpulan data sekunder berupa data time series. Penelitian menggunakan analisis regresi linier berganda, pengujian hipotesis dengan Uji parsial (uji t), uji simultan (uji F) dengan tingkat alfa 5%, uji koefisien determinasi (R2). Dengan Uji asumsi klasik yaitu Uji Normalitas, Uji Multikolinieritas, Uji Heteroskedastisitas dan Uji Autokorelasi.
Hasil menunjukan secara parsial variabel realisasi dana bagi hasil berpengaruh positif namun tidak signifikan terhadap sisa lebih pembiayaan anggaran (SILPA), variabel realisasi dana alokasi umum berpengaruh positif dan signifikan terhadap sisa lebih pembiayaan anggaran (SILPA) , variabel realisasi dana alokasi khusus berpengaruh positif namun tidak signifikan terhadap sisa lebih pembiayaan anggaran (SILPA) . Rekomendasi yang diajukan agar pemerintah lebih inovatif dalam penyusunan APBD. Penentuan prioritas plafon anggaran dan melakukan penyesuaian terkait komponen-komponen dalam APBD agar sesuai dengan kebutuhan pembangunan.
Pengaruh Electronic Word Of Mouth Terhadap Minat Berkunjung Dengan Mediasi Theory Of Planned Behavior Pada Obyek Wisata Halal Di Kabupaten Jombang
Authors: Purwanto Nuri , Rofiah Chusnul 
Published: November 2020

This study aims to determine the effect of the effect of electronic word of mouth on halal travel interest mediated by Theory of planned behavior (TPB). The research method uses quantitative by using explanatory research types. The population in this study were all visitors of religious tourism in Jombang Regency who learned information about these religious tourism from social media. While the sampling technique is purposive random sampling where sampling from the population is carried out randomly and with certain considerations by taking a number of 332 respondents, research results show that ewom influences the dimensions of Theory Planned Behavior namely subjective norm, attitude and Percected behavior control, as well as subjective norms and attitudes directly affect inttention to travel, ewom indirectly influences inttention to travel through atttitude and perceived behavior control