bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flexible Membrane Consisting of MoP Ultrafine Nanoparticles Highly Distributed Inside N and P Codoped Carbon Nanofibers as High‐Performance Anode for Potassium‐Ion Batteries
Authors: Yi Zhibin , Liu Ying , Li Yingzhi , Zhou Liangjun , Wang Zhenyu , Zhang Jianqiao , Cheng Hua , Lu Zhouguang 
Published: December 2019

AbstractRechargeable potassium‐ion batteries (PIBs) have attracted tremendous attention as potential electrical energy storage systems due to the special merit of abundant resources and low cost of potassium. However, one critical barrier to achieve practical application of PIBs has been the lack of suitable electrode materials. Here, a novel flexible membrane consisting of N, P codoped carbon nanofibers decorated with MoP ultrafine nanoparticles (MoP@NPCNFs) is fabricated via a simple electrospinning method combined with the later carbonization and phosphorization process. The 3D porous CNF structure in the as‐synthesized composite can shorten the transport pathways of K‐ions and improve the conductivity of electrons. The ultrafine MoP nanoparticles can guarantee high specific capacity and the N, P co‐doping could improve wettability of electrodes to electrolytes. As expected, the free‐standing MoP@NPCNF electrode demonstrates a high capacity of 320 mAh g−1 at 100 mA g−1, a superior rate capability maintaining 220 mAh g−1 at 2 A g−1, as well as a capacity retention of more than 90% even after 200 cycles. The excellent rate performance, high reversible capacity, long‐term cycling stability, and facile synthesis routine make this hybrid membrane promising anode for potassium‐ion batteries.
Designing Highly Conductive Functional Groups Improving Guest–Host Interactions in Li/S Batteries
Authors: Agostini Marco , Matic Aleksandar 
Published: December 2019

AbstractLi‐sulfur batteries are of great interest due to their potential to surpass the energy densities of other battery types, but the low electronic conductivity of both sulfur and its discharge products requires the use of a conductive host material. The most common is the use of different porous carbons which normally are hydrophobic and hardly retain the polar discharge products of the Li/S reaction, such as Li2S and lithium polysulfides (LiPs), at the working electrode. Functionalized hosts have been proposed as a strategy to improve LiPs interactions, including the use of heteroatom doping, organic frameworks, metals, metal oxides, sulfide particles, and conductive polymers. Despite demonstrating an improved cycle life, the functionalized structures often have an intrinsic limitation related to a low electronic conductivity resulting in slow kinetics and poor rate capability of Li/S cells. Herein, recent research trends aimed at designing sulfur electrodes with highly conductive functional groups on nanostructured hosts surface are reviewed. The main concepts, key developments, and parameters for building 3D hosts architectures that enable fast charge rates and long cycle life at high sulfur loadings are discussed.
Ingenieurmethoden im Parkhausbau
Authors: Upmeyer Jens , Kleibömer Inka , Meyer Patrick 
Published: December 2019

AbstractHerrn Prof. Dr.‐Ing. Peter Schaumann zum 65. Geburtstag gewidmetDer Einsatz von Ingenieurmethoden zur Tragwerksbemessung im Brandfall ermöglicht es, ungeschützte Stahl‐ und Verbundtragwerke in offenen Parkgaragen auch dann zu realisieren, wenn baurechtliche Anforderungen an den Feuerwiderstand gestellt werden. Besonders wirtschaftliche Konstruktionen sind möglich, wenn reale Tragstrukturen unter der Einwirkung realer Brandszenarien nachgewiesen werden. Dazu wird die Temperaturverteilung infolge eines lokalen Brandszenarios in einem Brandsimulationsmodell ermittelt und als Eingangswert an die FE‐Software zur thermischen und mechanischen Berechnung der Bauteile übergeben. Hierzu wurde eine Schnittstelle zwischen den Programmen FDS und SAFIR entwickelt.In diesem Beitrag werden die Grundlagen der Kopplung von FDS und SAFIR erläutert und mit den etablierten Ingenieurmethoden zur Bemessung einer Stahlverbundkonstruktion an einem Beispiel gegenübergestellt. Anhand des mittels verschiedenen methodischen Ansätzen ermittelten Erwärmungs‐ und Tragverhaltens wird gezeigt, dass die entwickelte Kopplung der Brandsimulations‐ und FE‐Software eine wesentlich wirtschaftlichere Bemessung für offene Parkgaragen ermöglicht, da die Widerstände realitätsnah berücksichtigt werden.
Bisphenols B, E, F, and S and 4‐cumylphenol induce lipid accumulation in mouse adipocytes similarly to bisphenol A
Authors: Ramskov Tetzlaff Cecilie N. , Svingen Terje , Vinggaard Anne M. , Rosenmai Anna K. , Taxvig Camilla 
Published: December 2019

AbstractBisphenol A (BPA) has been widely reported to exert endocrine disrupting effects, including the induction of adipogenesis in cultured preadipocytes and intact animals. Because of the potential harm to human health, BPA is being substituted by structurally related bisphenols. Whether or not such BPA analogues are safe substitutes, however, remains largely unknown. Here, we investigated the potential of bisphenol B (BPB), bisphenol E (BPE), bisphenol F (BPF), bisphenol S (BPS), and 4‐cumylphenol (4‐CP) to affect lipid and hormone levels in 3 T3‐L1 cells. We found that BPB, BPE, BPF, BPS, and 4‐CP all affected lipid accumulation and leptin levels to the same extent and potencies as BPA. Based on these and other results, we conclude that these BPA analogues and 4‐CP most likely will elicit similar effects on adipocytes as BPA. Using them to substitute BPA in products should be done with caution.
TGFβ-induced metabolic reprogramming during epithelial-to-mesenchymal transition in cancer
Authors: Hua Wan , ten Dijke Peter , Kostidis Sarantos , Giera Martin , Hornsveld Marten 
Published: December 2019

AbstractMetastasis is the most frequent cause of death in cancer patients. Epithelial-to-mesenchymal transition (EMT) is the process in which cells lose epithelial integrity and become motile, a critical step for cancer cell invasion, drug resistance and immune evasion. The transforming growth factor-β (TGFβ) signaling pathway is a major driver of EMT. Increasing evidence demonstrates that metabolic reprogramming is a hallmark of cancer and extensive metabolic changes are observed during EMT. The aim of this review is to summarize and interconnect recent findings that illustrate how changes in glycolysis, mitochondrial, lipid and choline metabolism coincide and functionally contribute to TGFβ-induced EMT. We describe TGFβ signaling is involved in stimulating both glycolysis and mitochondrial respiration. Interestingly, the subsequent metabolic consequences for the redox state and lipid metabolism in cancer cells are found to be in favor of EMT as well. Combined we illustrate that a better understanding of the mechanistic links between TGFβ signaling, cancer metabolism and EMT holds promising strategies for cancer therapy, some of which are already actively being explored in the clinic.
Prospective examination of synthetic 5-methoxy-N,N-dimethyltryptamine inhalation: effects on salivary IL-6, cortisol levels, affect, and non-judgment
Authors: Uthaug Malin V , Lancelotta Rafael , Szabo Attila , Davis Alan K , Riba Jordi , Ramaekers Johannes G 
Published: December 2019

Abstract
Rationale
5-methoxy-N,N-dimethyltryptamine is a psychotropic substance found in various plant and animal species and is synthetically produced. 5-methoxy-N,N-dimethyltryptamine is used in naturalistic settings for spiritual exploration, recreation, or to address negative affect and mood problems. However, scientific knowledge on the effects of 5-methoxy-N,N-dimethyltryptamine in humans is scarce.

Objectives
The first objective was to assess the effects of inhalation of vaporized synthetic 5-methoxy-N,N-dimethyltryptamine on neuroendocrine markers. The second objective was to assess effects of the substance on affect and mindfulness. In addition, we assessed whether ratings of subjective measures were associated with changes in stress biomarkers (i.e., cortisol) and immune response (i.e., IL-6, CRP, IL-1β), as well as the acute psychedelic experience.

Methods
Assessments (baseline, immediately post-session, and 7-day follow-up) were made in 11 participants. Salivary samples were collected at baseline and post-session and analyzed by high-sensitivity enzyme-linked immunosorbent assay (ELISA).

Results
5-methoxy-N,N-dimethyltryptamine significantly increased cortisol levels and decreased IL-6 concentrations in saliva immediately post-session. These changes were not correlated to ratings of mental health or the psychedelic experience. Relative to baseline, ratings of non-judgment significantly increased, and ratings of depression decreased immediately post-session and at follow-up. Ratings of anxiety and stress decreased from baseline to 7-day follow-up. Participant ratings of the psychedelic experience correlated negatively with ratings of affect and positively with ratings of non-judgment.

Conclusion
Inhalation of vaporized synthetic 5-methoxy-N,N-dimethyltryptamine produced significant changes in inflammatory markers, improved affect, and non-judgment in volunteers. Future research should examine the effect of 5-methoxy-N,N-dimethyltryptamineamine with healthy volunteers in a controlled laboratory setting.
Lipidomics from sample preparation to data analysis: a primer
Authors: Züllig Thomas , Trötzmüller Martin , Köfeler Harald C. 
Published: December 2019

AbstractLipids are amongst the most important organic compounds in living organisms, where they serve as building blocks for cellular membranes as well as energy storage and signaling molecules. Lipidomics is the science of the large-scale determination of individual lipid species, and the underlying analytical technology that is used to identify and quantify the lipidome is generally mass spectrometry (MS). This review article provides an overview of the crucial steps in MS-based lipidomics workflows, including sample preparation, either liquid–liquid or solid-phase extraction, derivatization, chromatography, ion-mobility spectrometry, MS, and data processing by various software packages. The associated concepts are discussed from a technical perspective as well as in terms of their application. Furthermore, this article sheds light on recent advances in the technology used in this field and its current limitations. Particular emphasis is placed on data quality assurance and adequate data reporting; some of the most common pitfalls in lipidomics are discussed, along with how to circumvent them.
Making MRI available for patients with cardiac implantable electronic devices: growing need and barriers to change
Authors: Bhuva A. N. , Moralee R. , Moon J. C. , Manisty C. H. 
Published: December 2019

Abstract
More than half of us will need a magnetic resonance imaging (MRI) scan in our lifetimes. MRI is an unmatched diagnostic test for an expanding range of indications including neurological and musculoskeletal disorders, cancer diagnosis, and treatment planning. Unfortunately, patients with cardiac pacemakers or defibrillators have historically been prevented from having MRI because of safety concerns. This results in delayed diagnoses, more invasive investigations, and increased cost. Major developments have addressed this—newer devices are designed to be safe in MRI machines under specific conditions, and older legacy devices can be scanned provided strict protocols are followed. This service however remains difficult to deliver sustainably worldwide: MRI provision remains grossly inadequate because patients are less likely to be referred, and face difficulties accessing services even when referred. Barriers still exist but are no longer technical. These include logistical hurdles (poor cardiology and radiology interaction at physician and technician levels), financial incentives (re-imbursement is either absent or fails to acknowledge the complexity), and education (physicians self-censor MRI requests). This article therefore highlights the recent changes in the clinical, logistical, and regulatory landscape. The aim of the article is to enable and encourage healthcare providers and local champions to build MRI services urgently for cardiac device patients, so that they may benefit from the same access to MRI as everyone else.

Key Points
• There is now considerable evidence that MRI can be provided safely to patients with cardiac implantable electronic devices (CIEDs). However, the volume of MRI scans delivered to patients with CIEDs is fifty times lower than that of the estimated need, and patients are approximately fifty times less likely to be referred.
• Because scans for this patient group are frequently for cancer diagnosis and treatment planning, MRI services need to develop rapidly, but the barriers are no longer technical.
• New services face logistical, educational, and financial hurdles which can be addressed effectively to establish a sustainable service at scale.
Optimal timing for prediction of pathologic complete response to neoadjuvant chemoradiotherapy with diffusion-weighted MRI in patients with esophageal cancer
Authors: Borggreve Alicia S. , Heethuis Sophie E. , Boekhoff Mick R. , Goense Lucas , van Rossum Peter S. N. , Brosens Lodewijk A. A. , van Lier Astrid L. H. M. W. , van Hillegersberg Richard , Lagendijk Jan J. W. , Mook Stella , Ruurda Jelle P. , Meijer Gert J. 
Published: December 2019

Abstract
Objective
This study was conducted in order to determine the optimal timing of diffusion-weighted magnetic resonance imaging (DW-MRI) for prediction of pathologic complete response (pCR) to neoadjuvant chemoradiotherapy (nCRT) for esophageal cancer.

Methods
Patients with esophageal adenocarcinoma or squamous cell carcinoma who planned to undergo nCRT followed by surgery were enrolled in this prospective study. Patients underwent six DW-MRI scans: one baseline scan before the start of nCRT and weekly scans during 5 weeks of nCRT. Relative changes in mean apparent diffusion coefficient (ADC) values between the baseline scans and the scans during nCRT (ΔADC(%)) were compared between pathologic complete responders (pCR) and non-pCR (tumor regression grades 2–5). The discriminative ability of ΔADC(%) was determined based on the c-statistic.

Results
A total of 24 patients with 142 DW-MRI scans were included. pCR was observed in seven patients (29%). ΔADC(%) from baseline to week 2 was significantly higher in patients with pCR versus non-pCR (median [IQR], 36% [30%, 41%] for pCR versus 16% [14%, 29%] for non-pCR, p = 0.004). The ΔADC(%) of the second week in combination with histology resulted in the highest c-statistic for the prediction of pCR versus non-pCR (0.87). The c-statistic of this model increased to 0.97 after additional exclusion of patients with a small tumor volume (< 7 mL, n = 3) and tumor histology of the resection specimen other than adenocarcinoma or squamous cell carcinoma (n = 1).

Conclusion
The relative change in tumor ADC (ΔADC(%)) during the first 2 weeks of nCRT is the most predictive for pathologic complete response to nCRT in esophageal cancer patients.

Key Points
• DW-MRI during the second week of neoadjuvant chemoradiotherapy is most predictive for pathologic complete response in esophageal cancer.
• A model including ΔADCweek 2was able to discriminate between pathologic complete responders and non-pathologic complete responders in 87%.
• Improvements in future MRI studies for esophageal cancer may be obtained by incorporating motion management techniques.
Characteristics of lacrimal passage diseases by 80-MHz ultrasound biomicroscopy: an observational study
Authors: Yan Xiaoqin , Xiang Nan , Hu Weikun , Liu Rong , Luo Ban 
Published: December 2019

Abstract
Purpose
To investigate the microstructure of the lacrimal canaliculus and the characteristics of lacrimal canalicular diseases by 80-MHz ultrasound biomicroscopy (UBM).

Methods
This study included 33 participants: 20 normal subjects (40 eyes), 2 patients with chronic lacrimal canaliculitis (4 eyes), 10 patients with chronic dacryocystitis (16 eyes), and 1 patient with lacrimal punctum atresia (2 eyes). All participants underwent 80-MHz UBM; disease-specific features were noted.

Results
On 80-MHz UBM of the lacrimal canaliculi (vertical section) in normal subjects, low echo of the lacrimal canalicular lumen and high echo of the lacrimal canalicular wall were observed. The uniform low echo near the wall was the mucosal epithelium. The outermost layer of medium-to-high echo was the subepithelial elastic fibrous layer. In the horizontal section, the lumen was continuous. Two linear high echoes parallel to the canalicular wall could be observed at the center of the lacrimal canaliculus, which were sometimes attached and sometimes separated. When separated, the center of the lacrimal canaliculus was a low echo area (lumen). Lacrimal canaliculitis (vertical section) showed obvious ectasia of the lacrimal canalicular lumen, with a high echo mass shadow, which might have been calculi, and uneven thickness of the mucosal epithelium with a slightly high echo shadow. In the horizontal section, the lumen varied in size with clear boundaries of medium and high echoes. The central linear high echoes of the lumen were absent, and the echoes of the mucosal epithelium were discontinuous. In chronic dacryocystitis, the lacrimal canalicular lumen was extensively enlarged, with continuous echoes and uniform thickness of the mucosal epithelium and homogeneous patches of slightly higher echoes. Lacrimal punctum atresia indicated that the lacrimal canaliculus existed in both eyes and its structure was normal.

Conclusions
The 80-MHz UBM is a new non-invasive technique that can be used for clear visualization of the fine structure of the lacrimal canaliculus, including the mucosal epithelium and subepithelial elastic fiber layer. The use of this approach will improve understanding of the hierarchical structure of the lacrimal canaliculi and provide a comprehensive basis for diagnosis, differential diagnosis, and treatment plan in patients with lacrimal passage diseases.
How I do it? Uniportal full endoscopic contralateral approach for lumbar foraminal stenosis with double crush syndrome
Authors: Wu Pang Hung , Kim Hyeun Sung , Jang Il-Tae 
Published: December 2019

AbstractBackgroundEvolution of endoscopic surgery provides equivalent results to open surgery with advantages of minimal invasive surgery. The literature on technique Uniportal Full endoscopic contralateral approach is scarce.MethodsThe endoscopic contralateral approach technique applies for patients presenting with double crush syndrome with foraminal and extraforminal stenosis. The key steps focus on contralateral ventral overriding superior articular process decompression, foraminal and extraforaminal discectomy, and lateral vertebral syndesmophyte decompression leading to enlargement of the contralateral foramen and extraforamen size.ConclusionThe Uniportal Full endoscopic contralateral approach is a good alternative to open surgery or minimally invasive microscopic surgery through direct endoscopic visualization of the entire route of exiting nerve with no neural retraction allowing both lateral recess and foraminal and extraforaminal decompression all in one approach.
The verb and noun test for peri-operative testing (VAN-POP): standardized language tests for navigated transcranial magnetic stimulation and direct electrical stimulation
Authors: Ohlerth Ann-Katrin , Valentin Antonio , Vergani Francesco , Ashkan Keyoumars , Bastiaanse Roelien 
Published: December 2019

Abstract
Background
Protocols for intraoperative language mapping with direct electrical stimulation (DES) often include various language tasks triggering both nouns and verbs in sentences. Such protocols are not readily available for navigated transcranial magnetic stimulation (nTMS), where only single word object naming is generally used. Here, we present the development, norming, and standardization of the verb and noun test for peri-operative testing (VAN-POP) that measures language skills more extensively.

Methods
The VAN-POP tests noun and verb retrieval in sentence context. Items are marked and balanced for several linguistic factors known to influence word retrieval. The VAN-POP was administered in English, German, and Dutch under conditions that are used for nTMS and DES paradigms. For each language, 30 speakers were tested.

Results
At least 50 items per task per language were named fluently and reached a high naming agreement.

Conclusion
The protocol proved to be suitable for pre- and intraoperative language mapping with nTMS and DES.
The “Salcher” landslide observatory—experimental long-term monitoring in the Flysch Zone of Lower Austria
Authors: Stumvoll M. J. , Canli E. , Engels A. , Thiebes B. , Groiss B. , Glade T. , Schweigl J. , Bertagnoli M. 
Published: December 2019

AbstractShallow landslide processes in geologically prone areas are recognised to pose threat to both human life and property. As precipitation is one of the main triggers for landslides, hydro-meteorological interrelationships and related future changes regarding frequency and magnitude of landslide processes in particular are of major interest. Long-term monitoring investigations of active landslide sites can provide a better understanding of the kinematic behaviour and triggering conditions of slope instabilities induced by hydro-meteorological patterns. In this study, we present the installation and first results of a long-term monitoring setup in the Flysch Zone of Lower Austria equipped with a large variety of combined hydrological and geotechnical measuring techniques. The geological unit of the Flysch Zone, characterised by high contents of clay and the corresponding weathering products, is exceptionally prone to earth and debris slides which are mostly triggered by heavy precipitation events or snow melting. The landslide under investigation is situated in the heterogeneous lithology of Flysch deposits, surrounded by private property and without any agricultural usage. There is evidence of landslide activity since the 1950s. As it is showing only moderate displacement velocities (max. 20 cm in 2009), it represents a predestined study site for a long-term monitoring and the testing of new monitoring techniques. One of the main aims of this study is to characterise the internal structure, assess the current landslide dynamics and to analyse recent process activity by means of surface and subsurface monitoring installations. Surface methods currently include terrestrial laser scanning, GNSS and total station measurements. With these, surface movement rates of approx. 12 cm/6 months have been detected in the most active part of the landslide. Inclinometer measurements together with results from core drillings and penetrations tests suggest a complex, rotational landslide system with different shear zones, consisting of a more active part in the upper 3 m underlain by a less active part down to 9-m depth. As this monitoring site is designed to be operated for at least 10 years, information about its structure and high-resolution, multi-temporal data about its dynamics can be correlated with hydrological cause variables in the future. These insights and the exemplary nature of the study site regarding shallow landslide processes in Flysch deposits will be useful for the development of novel analysis methods for both Lower Austria as well as study sites with similar initial conditions.