bluuebunny/crossref_metadata_2025_split huggingface dataset:
Different criteria affect prevalence of relapse of behavior targeted for treatment
Authors: Podlesnik Christopher A. , Ritchey Carolyn M. , Muething Colin , Falligant John Michael 
Published: December 2024

AbstractSeveral studies have examined the prevalence of behavioral relapse among individuals with intellectual and developmental disabilities following common treatment challenges (context changes, schedule thinning). Most applied studies compare behavior during the treatment challenges with the maximum level of behavior from five preceding treatment sessions. This max‐of‐5 criterion could inadvertently capture behavior in transition during the preceding treatment phase, thereby underestimating the prevalence of relapse. In the current study, we reanalyzed existing clinical data with the max‐of‐5 criterion and an alternative criterion less likely to capture target behavior in transition—the mean of the last two sessions (mean‐of‐2 criterion) of the treatment phase. As hypothesized, the max‐of‐5 criterion produced lower prevalence estimates relative to the mean‐of‐2 criterion. We encourage researchers conducting these analyses to weigh different approaches to reporting prevalence data and discuss considerations for future areas of research and practice related to measurement of relapse.
Toxicological Safety Assessment of Heat‐Treated Lactiplantibacillus plantarum OLL2712 as a Food Ingredient
Authors: Parente Ryan M. , Toshimitsu Takayuki , Nakamoto Youko , Taguchi Tomoyasu 
Published: December 2024

ABSTRACTLactiplantibacillus plantarum is a Gram‐positive, bacilli‐shaped bacterium commonly found in fermented foods and the human gastrointestinal tract. Heat‐treatment of L. plantarum OLL2712 prior to consumption has been found to have positive health effects. However, a full toxicological evaluation of heat‐treated L. plantarum OLL2712 cells (heat‐treated OLL2712) has not been conducted. In this regard, heat‐treated OLL2712 was evaluated for use as an ingredient in food and dietary supplements using a panel of toxicological tests including genotoxic and subchronic studies. Heat‐treated OLL2712 did not show any genotoxicity based on an in vitro mammalian chromosomal aberration test and in vivo mouse micronucleus assay up to 8.0 × 109 cells/mL and 6.4 × 1012 cells/kg, respectively. In the acute oral toxicity study, no toxic effects were observed at 5 × 1011 cells/kg body weight. In the 13‐week subchronic toxicity study, rats were administered (via gavage) heat‐treated OLL2712 at concentrations of 0.5 × 1011, 1.5 × 1011, and 5 × 1011 cells/kg body weight. Administration did not significantly impact mortality, body weight, food consumption, ophthalmology, hematology, clinical chemistry, coagulation, urinalysis, and macroscopic or microscopic findings. The no‐observed‐adverse‐effect level of heat‐treated OLL2712 in both sexes was 5 × 1011 cells/kg body weight/day, the highest dose tested.
Pilot Study of Acute and Subchronic Oral Toxicological Biosafety Evaluation of Resorcinol‐Formaldehyde Aerogel Nanomaterial in Kunming Mice
Authors: Zheng Guangzhen , Zhu Yong , Wu Bingmin , Xu Xiaoyuan , Cheng Juanjuan , Liu Yan , Huang Song , Chen Jing , Xiong Qingping , Chen Jihang 
Published: December 2024

ABSTRACTResorcinol‐formaldehyde aerogel (RFa) is a unique nanomaterial composed of polymer nanoparticles with a three‐dimensional network structure. Our previous studies have demonstrated its application in the separation and purification of alkaloids, and we are exploring its application potential as the drug delivery carrier. Therefore, it is necessary to comprehensively understand the in vivo toxicity profile of RFa and evaluate its oral biosafety. In this work, we systematically evaluated the in vivo acute toxicity and subchronic oral toxicity of RFa in both male and female Kunming mice. During the 14‐day acute toxicity test, the dose administered (M = 580 mg/kg) was converted from the clinical dose of adsorbed alkaloids on RFa. The mice were gavaged only once and were observed continuously for 14 days. There were no abnormalities, and pathological changes in the major organs (heart, liver, spleen, lungs, kidneys, testes, and ovaries) were detected, followed by the 12‐week subchronic toxicity test at the dose of 1/4M, 1/2M, and M. All mice were administered orally once daily and regularly observed throughout the experimental period. As a result, no abnormalities were found in body weights, food intake, and organ coefficients. Tissue section revealed no pathological changes in the major organs. In addition, there were no significant differences in hematological, blood biochemical, and coagulation parameters in both male and female mice compared to control group. These results showed that RFa was well tolerated at these dosage levels and did not cause significant toxic effects in Kunming mice. This study, as part of a broad research program on the biosafety of aerogel nanomaterials, provided the biosafety assurance for the subsequent study of RFa in biomedical applications.
Arthroscopic meniscal surgery in Norway from 2010 to 2020: A paradigmatic shift
Authors: Nilsen Karoline Nysted , Øhrn Frank‐David , Årøen Asbjørn , Myklebust Tor Åge , Aae Tommy Frøseth 
Published: December 2024

ABSTRACTPurposeMeniscal injuries in the knee are usually treated surgically with arthroscopic partial resection (APR) or arthroscopic repair (AR). APR has been shown to increase the risk of osteoarthritis and the focus has shifted to repairing the meniscus with AR. The extent of this shift is yet to be established and an analysis of incidence rates (IR) of APR and AR for meniscal injuries could highlight this.MethodsData from the Norwegian Patient Registry (NPR) and Statistics Norway (SN) from 2010 to 2020 were collected. The number of procedures, demographics and facilities providing meniscal surgery were obtained from NPR, while population size and catchment area were collected from SN. IR of APR and AR and APR/AR rate ratios were estimated and compared.ResultsA total of 119,528 knee arthroscopies were performed, 89.6% of which were APR. The number of APR performed nationally decreased by 72%, while AR procedures increased by 178%. The national IR of APR decreased from 298 to 82/100,000 inhabitants (p < 0.001). For AR, the national IR increased annually from 13/100,000 inhabitants to a peak in 2019 of 32/100,000 inhabitants (p < 0.001). The APR/AR rate ratio decreased from 22 to below five and the APR/AR trend curves showed a statistically significant decrease (p < 0.001).ConclusionSurgical treatment of meniscal injuries has changed, with a substantial reduction in APR and a strong increase in AR. The reduction in APR, especially in older patients, suggests that meniscal surgery in Norway has undergone a paradigmatic shift, in line with recent literature.Level of EvidenceLevel IV.
Controlling Spatial Heterogeneity of Land Transfer Dynamics Using Multiscale Regression Approach for Sustainable Resource Management
Authors: Wang Ao , Kafy Abdulla Al , Feng Yanfei , Altuwaijri Hamad Ahmed , Song Lingfeng , Lin Li 
Published: December 2024

ABSTRACTLand reallocation dynamics play a crucial role in shaping urban development and environmental sustainability in rapidly urbanizing countries. This study employs Geographically Weighted Regression (GWR) and Multiscale GWR (MGWR) models to analyze the spatial heterogeneity of land reallocation drivers across 285 Chinese cities, focusing on years 2008 and 2013. Our results reveal significant spatial variations in drivers of land reallocation, with energy intensity and foreign trade openness emerging as most influential factors. MGWR model consistently outperformed the classical GWR model, as evidenced by lower Akaike Information Criterion Corrected values (664.75 vs. 742.84) and a reduced sum of squares of residuals (130.44 vs. 165.31). This demonstrates multi‐scale nature of land reallocation processes and superiority of MGWR in capturing these complex spatial relationships. We find that the impact of energy intensity on land reallocation is particularly strong in northern China, with coefficients ranging from 0.208 to 0.761 in 2008. Foreign trade openness shows a more significant influence in coastal regions, with coefficients up to 1.078 in 2008. Interestingly, urbanization rate didn't show statistically significant effects, challenging some prevailing assumptions about urban growth drivers. Temporal analysis revealed a general decrease in magnitude of effects from 2008 to 2013, suggesting evolving dynamics in China's land reallocation processes. These findings have significant implications for sustainable land management and urban planning policies in China and other rapidly urbanizing countries. Our study adds to the literature by offering a detailed, spatially explicit understanding of land reallocation dynamics, providing valuable insights for achieving SDG 15.3 on land degradation neutrality.
Effect of Land‐Use Management on Soil Erosion Under Two Distinct Climates of Indian Himalayas
Authors: Wani Owais Ali , Sharma Vikas , Babu Subhash , Kumar Shamal Shasang , Sharma K. R. , Dar S. R. , Malik A. R. , Yadav Devideen , Singh Raghavendra , Rathore Sanjay Singh 
Published: December 2024

ABSTRACTSoil erosion is a growing concern, especially in regions where the combination of climate, land‐use, and soil characteristics increases the risk of degradation. The study utilized a stratified random sampling method across various land‐use types in both subtropical and temperate climatic zones of the Indian Himalayas. A total of 50 sampling locations were strategically selected, with 25 in each climate zone, to ensure representative data collection. Soil samples were collected from two depths (0 to 15 cm and 15 to 30 cm) for thorough analysis. This study set out to examine several key indicators of soil erodibility factors like the dispersion ratio (DR), clay/moisture equivalent (meq) ratio (CMR), percolation ratio (PR), clay ratio (CR), erosion ratio (ER), moisture equivalent (ME), critical level of organic matter (CLOM), and particle size distribution across different land‐uses in both subtropical and temperate climates. The goal was to better understand how these factors interact and what that means for soil health in vulnerable areas. The results suggest that soils in subtropical climates are generally more prone to erosion than those in temperate regions, regardless of how the land is used. For example, subtropical wastelands exhibited the highest levels of erodibility, with particularly high DR (19.20), PR (15.54), and ER (23.91), while temperate wastelands had a higher CR (2.12). On the other hand, undisturbed forest areas in both climates had the lowest risk of erosion, due to their higher clay content, organic matter (OM), and other favorable soil properties. The findings highlights that subtropical soils are significantly more vulnerable to erosion, emphasizing the importance of targeted management strategies. The choice of land‐use can drastically influence soil erodibility, with horticultural practices presenting a viable approach to reducing soil loss while promoting livelihoods. Maintaining undisturbed forest areas is critical for protecting soil health and implementing thoughtful land‐use practices is essential for mitigating erosion risks and ensuring the sustainability of soil resources. These insights are particularly relevant for the Indian Himalayas, where sustainable land management is crucial for both environmental preservation and community well‐being. land‐useland‐useland‐useland‐useland‐useland‐use.
Numerical Modeling on Small‐Strain Stiffness and Viscoelastic‐Viscoplastic Characteristic of Soft Soils
Authors: Ai Zhi Yong , Gu Gan Lin , Yuan Jun Tao 
Published: December 2024

ABSTRACTThe behavior of soft soils distributed in coastal areas usually exhibits obvious time‐dependent behavior after loading. To reasonably describe the stress‐strain relationship of soft soils, this paper establishes a viscoelastic‐viscoplastic small‐strain constitutive model based on the component model and the hardening soil model with small‐strain stiffness (HSS model). First, the Perzyna's viscoplastic flow rule and the modified Hardin–Drnevich model are introduced to derive a one‐dimensional incremental Nishihara constitutive equation. Next, the flexibility coefficient matrix is utilized to extend the one‐dimensional model to three‐dimensional conditions. Then, by combining the HSS elastoplastic theory with the component model, the viscoelastic‐viscoplastic small‐strain constitutive model is subsequently established. To implement the proposed model for numerical analysis, the corresponding UMAT subroutine is developed using Fortran. After comparing the results of numerical simulations with those of existing literature, the reliability of the constitutive model and the program written in this paper is verified. Finally, numerical examples are designed to further analyze the effects of small‐strain parameters and viscoelastic‐viscoplastic parameters on the time‐dependent behavior of soft soils.
Safety and Tolerability of Intravenous Lidocaine Infusions as Opioid Adjunct for Children Hospitalized With Sickle Cell Vaso‐Occlusive Pain
Authors: Agbakwuru Ugochukwu , AuBuchon Jacob D. , Toebe Bobi , LaBarge Anne , Di Paola Jorge , Hulbert Monica L. 
Published: December 2024

ABSTRACTSickle cell disease (SCD) vaso‐occlusive episode (VOE) pain is treated with opioids, and non‐opioid adjuvants may reduce pain severity without opioid side effects. We retrospectively investigated the safety and tolerability of intravenous lidocaine infusions as an adjunct to opioids in children and adolescents during VOE hospitalizations. In 2 years, lidocaine was administered in 64.6% of 260 admissions. There were no serious toxicities; overall, 82.2% of recipients chose to receive lidocaine during subsequent admissions. Lidocaine infusions were associated with longer hospitalizations, potentially reflecting selection bias. The efficacy of adjuvant lidocaine infusions during VOE should be studied prospectively.
Stabilization of Networked Control Systems With Time Delays: An Observer‐Based Dynamic Quantized Control Approach
Authors: Zhang Huihui , Li Lulu , Lu Jianquan 
Published: December 2024

ABSTRACTIn this article, we propose an observer‐based dynamic quantized control approach to stabilize networked control systems plagued by time delays. Our first step involves designing an observer‐based dynamic quantizer that effectively circumvents saturation, even in the presence of time delays. Notably, the zoom variable of this quantizer can be discretely adjusted. Specifically, the interval between two consecutive adjustments of the zoom variable has a positive lower bound, which contributes to reduced energy consumption. Next, we consider unbounded time delays that may lead to packet loss in networked control systems with limited bit rate. We prove that the system stabilization relies on a mild assumption on packet loss frequency. We then design a controller based on the quantized state of the observer to counteract time delays and maintain system performance. Finally, we provide three numerical examples to validate our theoretical results.
Preserving Integrative and Humanizing Literacies: A Commentary on the Current Literacy Debates and the Narrowing of Literacy Instruction
Authors: Jackson Davena , Johnson Wintre Foxworth , Frankel Katherine K. , Houston‐King Ashley 
Published: December 2024

AbstractThe present iteration of the “reading wars” has created intense debate about what constitutes rigorous and effective literacy instruction. Increasingly, politicized discourses have narrowed the field's definition of reading across education spaces (P‐20) and overemphasized foundational early literacy skills while minimizing the consequentiality of sociocultural influences on literacy learning. In this commentary, we engage and critique recent narratives about the nature of literacy learning among scholars, policymakers, practitioners, and in the popular media. We discuss what has been and will be silenced, erased, and sacrificed as a result of these debates. Further, we argue that literacy educators should not abandon the complexities of literacy learning and the social, political, and historical contexts in which students live and learn. To do this, we emphasize the importance of Black children and youth having opportunities to develop critical consciousness and learn through their lived experiences. Moreover, we take a developmental perspective and outline the implications of a more expansive approach to literacy instruction across elementary, secondary, and postsecondary contexts. Ultimately, we argue for a nuanced, integrative, and humanizing path forward that addresses Black children and other historically marginalized students' literacy needs; rejects deficit ideologies concerning what counts as reading; and cultivates children, adolescents, and adults' critical literacies.
Sandwich‐Like MXene@Mn3O4@PPy Hollow Microspheres Synergistically Enabled Ultra‐long Cycling Life in Aqueous Zinc Ion Batteries
Authors: Li Qun , Jiao Qingze , Li Zuze , Lu Chengxing , Yang Huan , Liu Yong , Yang Zhongnian , Feng Caihong 
Published: December 2024

AbstractManganese‐based oxides are be regarded as one of the most promising cathode materials for aqueous zinc ion batteries (AZIBs). A major restriction of manganese‐based oxides in practical applications is their unsatisfied structural stability due to the irreversible manganese dissolution. Additionally, the poor electrical conductivity also limits the rate capability. Herein, the sandwich‐like MXene@Mn3O4@PPy hollow microspheres are constructed via self‐sacrificial template and surface coating method to improve the cycling life of AZIBs. Benefiting from the unique sandwich‐like hollow structure and the surface coating of PPy, the MXene@Mn3O4@PPy cathode possesses high electronic/ionic conductivity and satisfied structural stability. The sandwich‐like MXene@Mn3O4@PPy hollow microspheres deliver excellent electrochemical performance, including an impressive rate capability and ultra‐long cycling life with a capacity of 120 mAh g−1 at 5 A g−1 after 9000 cycles. In addition, the systematic ex situ XRD and HRTEM characterizations verify the highly reversible Zn2+ and H+ insertion/desertion in the sandwich‐like MXene@Mn3O4@PPy hollow microspheres. This work combines hollow structure design and surface coating method to provide an effective strategy for improving the structural stability of manganese‐based oxides in AZIBs.
Improved Catalytic Performance of Lipase Within Hydrogel Microspheres Incorporating L/D‐Co3O4 Nanoparticles
Authors: Xing Xinhe , Yang Weimin , Li Junru , Ding Qi , Wang Fang , Lin Hengwei , Xu Liguang , Xu Chuanlai , Li Si 
Published: December 2024

AbstractLipases have drawn significant attention due to their crucial roles across various industries, including oil processing, food, medicine, and daily chemicals. Nevertheless, their catalytic efficiency is susceptible to fluctuations in external environmental conditions, which remains a major barrier to their broader application. In this research, chiral hydrogel microspheres (HMSs) are developed by incorporating L/D‐Co3O4 nanoparticles (NPs) into the synthetic process of HMSs, which are discovered to enhance the catalytic performance of lipases. The improved catalytic activity of lipases is observed to be influenced by the chiral environment of L/D‐Co3O4‐HMSs. Specifically, when 2 wt.% lipases are encapsulated in L‐Co3O4‐HMSs containing 10 wt.% L‐Co3O4 NPs, their catalytic activity is 2.11 times higher than when encapsulated in D‐Co3O4‐HMSs, resulting in a 2.62‐fold increase in catalytic activity compared to free lipase. Moreover, the L‐Lip‐HMS3, which contained 2 wt.% lipases and 10 wt.% L‐Co3O4 NPs, exhibited superior inhibitory capability over D‐Lip‐HMS3 in differentiating fibroblast mouse cells into adipocytes, owing to its enhanced catalytic capabilities. This study not only highlights the importance of chirality in improving the catalytic performance of natural enzymes but also provides a new perspective on developing catalytic systems that can endow natural enzymes with higher catalytic performances.
Revision of Sagenopteris (Caytoniales): a major lineage of the Mesozoic seed plants
Authors: Xu Yuanyuan , Barbacka Maria , Kapusta Paweł , Jarzynka Agata , Wang Yongdong , McLoughlin Stephen 
Published: December 2024

AbstractSagenopteris is the most common fossil organ attributed to Caytoniales and is represented by compound leaves having several (usually four) lanceolate leaflets in pseudo‐palmate arrangement. Since Presl's description of Sagenopteris in 1838, at least 82 species have been identified worldwide. However, most were established on a few isolated leaflets without sufficient details for confident segregation from other forms. After a global evaluation of the character states, nomenclature and taxonomic validity of all described Sagenopteris species, only five can be retained as nomenclaturally valid and morphologically distinct: Sagenopteris acuminata (lectotype species), S. colpodes, S. hallei, S. phillipsii and S. pualensis. Comprehensive assessment of Sagenopteris foliage based on historical studies and institutional collections shows a high degree of morphological plasticity within individual leaf populations. Multivariate plots of key leaf characters show broad morphotypes within populations that, if selectively sampled, might readily result in the recognition of multiple fossil‐species. Cuticular features are more stable for species‐level differentiation. Temporo‐spatial analysis of Sagenopteris suggests it originated in the European (palaeo‐subtropical) region by the Anisian (Middle Triassic) and underwent significant range expansion during the Late Triassic. Surviving the end‐Triassic mass extinction, Sagenopteris quickly became one of the dominant gymnosperms in the aftermath of the biotic crisis, reaching its peak abundance during the Early and Middle Jurassic. This taxon began to decline in floristic importance from the Late Jurassic to Late Cretaceous. The youngest occurrences of Sagenopteris, globally, are from Cenomanian–Campanian assemblages of middle to high northern latitudes. No examples are known from the Cenozoic.
Role of preoperative transarterial chemoembolization (TACE) in intermediate‐stage hepatocellular carcinoma (Hong Kong liver cancer stage IIB)
Authors: Nandy Kunal , Varty Gurudutt P. , Patkar Shraddha , Shah Tanvi , Gundavda Kaival , Gala Kunal , Shetty Nitin , Kulkarni Suyash , Goel Mahesh 
Published: December 2024

AbstractIntroductionTransarterial chemoembolization (TACE) has an established role in advanced HCC. The present study evaluates the role of TACE as a neoadjuvant modality in the management of intermediate HCC [Hong Kong Liver Cancer (HKLC) stage IIB].Materials and methodsA retrospective analysis of HCC patients treated between January 2010 and August 2022 was performed. Patients belonging to intermediate‐stage HCC (HKLC IIB) were divided into two groups, upfront surgery (UPS) and post‐TACE (pTACE). Propensity score matching was done, and the primary endpoint of the study was overall survival (OS).ResultsA total of 247 patients of HKLC IIB were identified during this period. Of these, 77 patients in each group were considered for analysis after propensity matching. The median follow‐up was 36.4 months (0.46–144.26). In the propensity matched population (n = 154), on an intention‐to‐treat analysis, the median OS of the UPS group and the pTACE group was 30.06 and 39.26 months, respectively (p value = 0.77). In patients who underwent curative resection, the median OS of the UPS group was 30.68 versus 90.97 months in the pTACE group (p value = 0.006) and median DFS was 13.56 months for the UPS group versus 44.02 months in the pTACE group, respectively (p value = 0.013).ConclusionIn intermediate‐stage hepatocellular carcinoma (HKLC IIB), pTACE can be used to better select patients with borderline resectability. Survival was significantly improved in patients who received pTACE and were able to undergo surgical resection.