bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Associated with the Poor Outcomes in Diabetic Patients with COVID-19
Authors: Rastad Hadith , Ejtahed Hanieh-Sadat , Ghorabi Armita Mahdavi , Safari Anis , Shahrestanaki Ehsan , Rezaei Mohammad , Niksima Mohammad Mahdi , Zakani Akram , Manshadi Seyede Hanieh Dehghan , Ochi Fatemeh , saedi Shabnam , Khodaparast Zeinab , Hassani Neda Shafiabadi , Azimzadeh Mehdi , Qorbani Mostafa 
Published: July 2020

Abstract
Background: Diabetic’s patients are supposed to experience higher rates of COVID-19 related poor outcomes. We aimed to determined factors predicting poor outcomes in hospitalized diabetic patients with COVID-19. Methods: This retrospective cohort study included all adult diabetic patients with radiological or laboratory confirmed COVID-19 who hospitalized between 20 February 2020 and 27 April 2020 in Alborz province, Iran. Data on demographic, medical history, and laboratory test at presentation were obtained from electronic medical records. Diagnosis of diabetes mellitus was self-reported. Comorbidities including cancer, rheumatism, immunodeficiency, or chronic diseases of respiratory, liver, and blood were classified as “other comorbidities” due to low frequency. The assessed poor outcomes were in-hospital mortality, need to ICU care, and receiving invasive mechanical ventilation. Self-reported. Multivariate logistic regression models were fitted to quantify the predictors of in-hospital mortality from COVID-19 in patients with DM. Results: Of 455 included patients, 98(21.5%) received ICU care, 65(14.3%) required invasive mechanical ventilation, and 79 (17.4%) dead. In the multivariate model, significant predictors of “death of COVID-19” were age 65 years or older (OR (95% CI): 2.0 (1.16-3.44), chronic kidney disease (CKD) (2.05 (1.16 -3.62), presence of “other comorbidities” (2.20 (1.04-4.63)), neutrophil count ≥ 8.0 × 10⁹/L )6.62 (3.73-11.7 ((, Hb level <12.5 g/dl (2.05 (1.13-3.72)(, and creatinine level ≥1.36 mg/dl (3.10 (1.38-6.98)). (All p –values < 0.05). Some of these factors were also associated with other assessed poor outcomes, e.g., need to ICU care or invasive mechanical ventilation.Conclusions: Diabetic patients with age 65 years or older, comorbidity CKD, “other comorbidities”, as well as neutrophil count ≥ 8.0 × 10⁹/L, Hb level <12.5 g/dl, and creatinine level ≥1.36 mg/dl, were more likely to dead after COVID-19. Presence of hypertension and cardiovascular disease were associated with none of the poor outcomes.
Chemotherapy is not necessary for early-stage serous and endometrioid ovarian cancer after undergoing comprehensive staging surgery
Authors: Li Shuqing , Zhu Zhiling 
Published: July 2020

Abstract
In order to investigate whether adjuvant chemotherapy is essential for patients with early-stage serous and endometrioid epithelial ovarian cancer, the present study collected data from the US Surveillance, Epidemiology and End Results database between 2004 and 2015. All subjects underwent comprehensive staging surgery and were diagnosed as stages IA-IIA, grade 1-2. A total of 2,644 patients were enrolled in the present study, among which 1,589 patients received platinum-based chemotherapy. Comparisons of categorical data were performed via χ2 tests. Variables with P<0.05 in univariate analyses were further analyzed using multiple logistic regression. Selection bias from the heterogeneity of demographic and clinical characteristics was avoided using propensity score matching. Cox proportional hazards models were applied to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), investigating the association between variables and 5-year overall survival. After the propensity score matching, there was an equal number of patients with or without chemotherapy (n=925). The results of the present study indicated that those aged ≥65 years were at an increased risk of ovarian cancer, and the age was associated with poor prognosis (HR, 1.486; CI, 1.208-1.827; P<0.001). Endometrioid carcinoma was associated with improved 5-year overall survival compared with serous cystadenocarcinoma (HR, 0.697; CI, 0.584-0.833; P<0.001). Chemotherapy could not prolong the 5-year overall survival of patients with early-stage serous and endometrioid ovarian cancer (HR, 1.092; CI, 0.954-1.249; P=0.201). These results demonstrated that adjuvant chemotherapy was unnecessary for patients with early-stage serous and endometrioid ovarian cancer after they underwent comprehensive staging surgery.
Barriers of Access and Utilization of Reproductive Health Services by Adolescents-Khartoum State-Sudan-2020: study protocol
Authors: Elnimeiri Mustafa Khidir Mustafa , Satti Shahenaz Seifaldeen Mustafa , Ibrahim Mohanad Kamaleldin Mahmoud 
Published: July 2020

Abstract
Background: Adolescence is widely defined as the time in life when the developing individual attains the skills and attributes necessary to become a productive and reproductive adult; Most adolescents are healthy, but there is still substantial premature death, illness, and injury among adolescents. Illnesses can hinder their ability to grow and develop to their full potential. Alcohol or tobacco use, lack of physical activity, unprotected sex and/or exposure to violence can jeopardize not only their current health, but also their health as adults or even health of their future children.Method: Community and institutional-based cross sectional study will be conducted in Khartoum State the seven localities will be included. This state is the national capital of Sudan, which has an area of 22,122km. The sample size of participant is estimated using the population formula (n=N/1+ (n*d) .The sample will be drawn using multistage cluster sampling.; Also the concerned bodies involved in delivery of reproductive health services for adolescents included in this study. Data will be collected using interview with key informants and administered pre-coded, pretested closed ended questionnaire with community participants. Data will be managed and analyzed using Statistical Package for Social Sciences version 21. Analysis is mostly univariate descriptive and bi-variate with Chi Square &Fischer Exact tests analysis to find associations between variables of interest.Discussion: The census of adolescents mounted to 25% of the population and thus it is important to care for such significant portion of the population to document their reproductive health problems and their access to health care services. The study is expected to generate base-line indicators about barriers of access to reproductive health services by adolescents that can be used for better planning, monitoring and evaluation of the delivered serviceslt. The research about barriers of access to reproductive health services by adolescents in Sudan is still limited and the information is scanty and scattered. Thus, it is necessary to conduct such study to enrich the current database.
Predicting Individual Survival After Curative Esophagectomy for Squamous Cell Carcinoma of Esophageal
Authors: Zhao Zhiyong , Huang Xiaolong , Chen Zhu , Zhu Biao , Gan Limin , Wu Ning 
Published: July 2020

Abstract
Background Esophageal cancer is one of the leading causes of cancer-related death worldwide 1 . Despite significant progress in the overall treatment of esophageal cancer in recent years, the prognosis for patients who require surgery remains poor. Methods The current paper studied the clinicopathological features of 503 patients who underwent radical esophagectomy at the Huashan Hospital of Fudan University between January 2005 and January 2015. Nomograms which predicted esophageal squamous cell carcinoma (ESCC) survival rates were established using the Cox proportional hazards regression model. Discrimination and calibration, calculated after bootstrapping, were used as a measure of accuracy. Results Multivariate analyses were used to select five independent prognostic variables to build the nomogram. These variables were pathological T stage, pathological N factor, rate of positive LNs, history of chronic obstructive pulmonary disease (COPD) and postoperative sepsis. The nomogram was built to predict the rates of overall survival (OS) and disease-free survival (DFS). The concordance indices of the nomogram prediction of OS and DFS were 0.720 and 0.707, respectively. Compared to the conventional TNM staging system, the nomogram has better predictive accuracy for survival (OS 0.720 vs 0.672, P<0.001; DFS 0.707 vs 0.667, P<0.001). Conclusions The aims of this study were to assess comorbidities and postoperative complications in patients with esophageal cancer and to design a nomogram for the prediction of long-term survival in patients with ESCC. To the best of the knowledge of the authors of this study, this is the first attempt to establish an ESCC nomogram based on comorbidities and postoperative complications using a relatively large cohort of patients.
Biosynthesis of Copper Oxide Nanoparticles by Marine Streptomyces MHM38 and their Preventive Efficacy Against Paracetamol-Inducing Hepatic Damage of Albino Rats
Authors: Hamed Moaz , Gazwi Hanaa S.S. , Youssif Asmaa M. 
Published: July 2020

Abstract
The authors have withdrawn this preprint due to author disagreement.
Spatio-temporal Mapping of Breast and Prostate Cancer in South Iran During 2014-2017
Authors: Montazeri Mahdieh , Hoseini Benyamin , Firouraghi Neda , Kiani Fatemeh , Raouf-Mobini Hosein , Biabangard Adele , Dadashi Ali , Zolfaghari Vahideh , Ahmadian Leila , Eslami Saeid , Bergquist Robert , Bagheri Nasser , Kiani Behzad 
Published: July 2020

Abstract
Background:
Breast and prostate cancers are the most common gender-specific malignancies. In developing countries, screening of all population at risk of cancers is impractical because of the healthcare resource limitations. Thus, determining the high-risk areas of Cancers might be an important step to conduct a screening program at high-risk areas. This study explores potential high-risk clusters in the incidence pattern of breast and prostate cancers in southern Iran.
Methods:
This cross-sectional study was conducted in the province of Kerman, South Iran. Patient data were aggregated at the county and district levels and the incidence rate per 100,000 people for both breast and prostate cancer were calculated. We used the natural break classification with five classes to produce descriptive maps. A spatial clustering analysis ( Anselin Local Moran’s I ) was used to identify potential clusters and outliers in the pattern of these cancers from 2014 to 2017.
Results:
The Age-Standardised Incidence Rate of breast cancer showed an increase from 29.93 to 32.27 cases per 100,000 people and prostate cancer from 13.93 to 15.47 cases per 100,000 during 2014–2017. Cluster analysis at the county level identified high-high clusters of breast cancer in the North-West of the province for all years, but the analysis at the district level showed high-high clusters for only two of the years. Furthermore, cluster analysis at the county and district levels of prostate cancer also identified high-high clusters in the North-West of the province for two years.
Conclusions:
North-West Kerman had a significantly higher incidence rate of both breast and prostate cancer. These findings may help to design tailored screening and surveillance systems. Furthermore, this study generates new hypotheses to test potential relationships between environmental risk factors and incidence of cancers in areas with higher cancer risk.
Environmental shaping of the bacterial and fungal community in infant bed dust and correlations with the airway microbiota
Authors: Sørensen Søren Johannes , Gupta Shashank , Hjelmsø Mathis H. , Lehtimäki Jenni , Li Xuanji , Mortensen Martin S. , Russel Jakob , rivedi Urvish , Rasmussen Morten A. , Stokholm Jakob , Bisgaard Hans 
Published: July 2020

Abstract
Background From early life, children are exposed to a multitude of environmental exposures, which may be of crucial importance for healthy development. Here, the environmental microbiota may be of particular interest as it represents the interface between environmental factors and the child. As infants in modern societies spend a considerable amount of time indoors, we hypothesize that the indoor bed dust microbiota might be an important factor for the child and for the early colonization of the airway microbiome. To explore this hypothesis, we analysed the influence of environmental exposures on 577 dust samples from the beds of infants together with 542 airway samples from the Copenhagen Prospective Studies on Asthma in Childhood 2010 cohort.Results Both bacterial and fungal community was profiled from the bed dust. Bacterial and fungal diversity in the bed dust was positively correlated with each other. Bacterial bed dust microbiota was influenced by multiple environmental factors, such as type of home (house or apartment), living environment (rural or urban), sex of siblings and presence of pets (cat and/or dog), whereas fungal bed dust microbiota was majorly influenced by the type of home (house or apartment) and sampling season. We further observed minor correlation between bed dust and airway microbiota compositions among infants. We also analysed the transfer of microbiota from bed dust to the airway, but we did not find evidence of transfer of individual taxa.Conclusions Current study explores the influence of environmental factors on bed dust microbiota (both bacterial and fungal) and its correlation with airway microbiota (bacterial) in early life using high-throughput sequencing. Our findings demonstrate that bed dust microbiota is influenced by multiple environmental exposures and could represent an interface between environment and child.
Requirement for Containing Etoposide in the Initial Treatment of Lymphoma Associated Hemophagocytic Lymphohistiocytosis
Authors: Song Yue , Wang Jingshi , Wang Yini , Wu Lin , Wang Zhao 
Published: July 2020

Abstract
Background: Hemophagocytic lymphohistiocytosis (HLH) is a severe or even fatal inflammatory status caused by a hereditary or acquired immunoregulatory abnormality. Lymphoma associated hemophagocytic lymphohistiocytosis (LAHS) is a kind of secondary HLH (sHLH). It has the worst prognosis among sHLH. However, there’s still no standard treatment strategy. The argument mainly focuses on whether an HLH-directed or malignancy-directed approach should initially be adopted. Etoposide is one of the key drugs in HLH treatment, also effective in lymphomas. We sought to identify the importance of containing etoposide in initial treatment, comparing with the chemotherapy which directed at lymphoma but without etoposide. Methods: 66 patients diagnosed as LAHS in our center between Jan 1 2015 and Dec 31 2017 were divided into two groups according to weather the initial treatment containing etoposide, or other lymphoma-directed chemotherapy without etoposide. Results: The remission rate of the initial etoposide group (52 patients) is significantly better than that of no initial etoposide group (14 patients) (73.1% vs. 42.9%, p = 0.033). The relapse occurrence between two groups shows difference (26.3% vs. 50%) but not significant (p = 0.339). There were 28 deaths in patients with initial etoposide (mortality rate 53.8%) and 12 deaths in the without-initial-etoposide group (mortality rate 85.7%). A significant difference in mortality was noted between the two groups (p = 0.030). The 2-month survival (79.8% vs. 46.8%, p = 0.019) and overall survival (median survival time 25.8w vs. 7.6w, p = 0.048) of the initial etoposide contained group is also better. Multivariate cox analysis revealed that for patients without EBV infection (37 cases), initial treatment with etoposide could significantly improve prognosis (p = 0.010, Exp(B) = 0.183), but for patients with positive EBV, it’s not significant. Conclusions: We concluded that containing etoposide is essential in the initial treatment of LAHS, weather using the HLH directed or lymphoma directed strategy. It provides higher response rate, lower mortality rate and better survival, especially for EBV negative patients.
Immune Checkpoint Inhibitors-related Myocarditis in Patients With Cancer: an Analysis of International Spontaneous Reporting Systems
Authors: Ma Rulan , Wang Quanziang , Meng Deyu , Li Kang , zhang yong 
Published: July 2020

Abstract
Background:Immune checkpoint inhibitors induced myocarditis presents unique clinical challenges. Here, we assessed post-marketing safety of PD-1, PD-L1 and CTLA-4 inhibitors by mining the real-world data reported in two international pharmacovigilance databases.Methods: We analyzed immune checkpoint inhibitors (ICIs)-associated fatal adverse drug events (ADRs) reports from the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) collected from July 1, 2014, to December 31, 2019, and data from EudraVigilance (EV) database accessed on February 29, 2020. Three different data mining methods were used to detect the signal of five fatal toxic effects caused by ICIs.Results: Based on 7613 ICIs-related ADEs reported to the EV database and 5786 ICIs-associated ADEs submitted to the FAERS database, the most frequently reported ADEwasipilimumab-related colitis. For myocarditis, nivolumab-associated myocarditis was the most common. Among the five fatal toxic effects associated with ICIs, the lethality rate of myocarditis was the highest. Elderly patients and male patients were more likely to develop ICIs-related myocarditis.The results of signal detection showed that the risk of avelumab-related myocarditis detected by reporting odds ratio (ROR) method and proportional reporting ratios (PRR) method was the highest, whereas the signal strength of ipilimumab-related myocarditis detected by Bayesian confidence propagation neural networks (BCNPP)method was the strongest.Conclusion:The findings of this study showed the risk of developing myocarditis and other fatal ADRs when using ICIs, which are consistent with the results of previous clinical trials and can provide a reference for clinical workers when using ICIs.
Comprehensive Analysis of PLOD Family Members in Low-grade Gliomas Using Bioinformatics Methods
Authors: Zhao Yonghui , Zhang Xiang , Yao Junchao 
Published: July 2020

Abstract
Low-grade gliomas (LGGs) is a primary invasive brain tumor that grows slowly but is incurable and eventually develops into high malignant glioma. Novel biomarkers for the tumorigenesis and lifetime of LGG are critically demanded to be investigated. In this study, the expression levels of procollagen-lysine, 2-oxoglutarate 5-dioxygenases (PLODs) were analyzed by ONCOMINE, HPA and GEPIA. The GEPIA online platform was applied to evaluate the interrelation between PLODs and survival index in LGG. Furthermore, functions of PLODs and co-expression genes were inspected by the DAVID. Moreover, we used TIMER, cBioportal, GeneMINIA and NetworkAnalyst analysis to reveal the mechanism of PLODs in LGG. We found that expression levels of each PLOD family members were up-regulated in patients with LGG. Higher expression of PLODs was closely related to shorter disease-free survival (DFS) and overall survival (OS). The findings showed that LGG cases with or without alterations were significantly correlated with the OS and DFS. The mechanism of PLODs in LGG may be involved in response to hypoxia, oxidoreductase activity, Lysine degradation and immune cell infiltration. In general, this research has investigated the values of PLODs in LGG, which could serve as biomarkers for diagnosis, prognosis and potential therapeutic targets of LGG patients.
Nutrition-oriented reformulation of extruded cereals and associated environmental footprint: a case study
Authors: Espinoza-Orias Namy , Vlassopoulos Antonis , Masset Gabriel 
Published: July 2020

Abstract
Background

The global food system faces a dual challenge for the decades ahead: providing nutritious food to a growing population while reducing its environmental footprint. Reformulation of food has been identified as a strategy to improve the nutritional quality of products; but the environmental consequences of such reformulations have rarely been studied. The objective was to assess the evolution of five environmental impact indicators following reformulations of extruded breakfast cereals.

Methods

Recipe, nutritional composition and sourcing data for three extruded breakfast cereals were retrieved from the manufacturer, at three distinctive time points of a 15-year reformulation cycle: 2003, 2010, and 2018. Nutritional information was summarized using the Nutri-Score indicator. The environmental impact of all recipes was assessed by Life Cycle Assessment (LCA) using five indicators: climate change (CC), Freshwater consumption scarcity (FWCS), Abiotic resource depletion (ARD), Land use impacts on biodiversity (LUIB), and Impacts on ecosphere/ecosystems quality (IEEQ). Life cycle inventory (LCI) was both primary data from the manufacturer and secondary data from usual third-party LCI datasets.

Results

Reformulation led to improved nutritional quality for all three products. In terms of environmental impact, improvements were observed for the CC, ARD and IEEQ indicators, with average reductions of 12%, 14% and 2% between 2003 and 208, respectively. Conversely, the FWCS and LUIB indicators were increased by 57% and 70%, respectively. For all indicators but ARD, ingredients contributed most to the environmental impact, while the absolute impacts of other stages of the supply chain (i.e. manufacturing, packaging, transport and end-of-life) reduced. A sensitivity analysis simulating no deforestation agricultural practices suggested that the CC indicator could be further reduced by 21 to 49% for the 2018 recipes.

Conclusions

This study highlighted the need to better account for the environmental consequences of changing food product recipes. While improvements can be achieved at all stages of products’ life cycles, agricultural commodities need to be the focus for further improvement, in particular in shelf-stable grain-based products such as extruded cereals. This could be achieved through selection of less demanding ingredients and improvements in agricultural practices.