bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibacterial silver-diatomite nanocomposite ceramic with low silver release
Authors: Qi Xiaopeng , Chen Junwei , Li Qian , Yang Hui , Jiang Honghui , Deng Yangwu , Song Qiuhua , Liang Tongxiang 
Published: December 2019

Abstract
There is an urgent need for an effective and long-lasting ceramic filter for point-of-use water treatment. In this study, silver-diatomite nanocomposite ceramic filters were developed by an easy and effective method. The ceramic filters have a three-dimensional interconnected pore structure and porosity of 50.85%. Characterizations of the silver-diatomite nanocomposite ceramic filters were performed using scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. Silver nanoparticles were confirmed to be formed in situ in the ceramic filter. The highest silver concentration in water was 0.24 μg/L and 2.1 μg/L in short- and long-term experiments, indicating very low silver-release properties of silver-diatomite nanocomposite ceramic filter. The nanocomposite ceramics show strong bactericidal activity. When contact time with Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) of 105 colony forming units (CFU)/mL exceeded 3 h, the bactericidal rates of the four different silver content ceramics against E. coli and S. aureus were all 100%. Strong bactericidal effect against E. coli with initial concentration of 109 CFU/mL were also observed in ceramic newly obtained and ceramic immersed in water for 270 days, demonstrating its high stability. The silver-diatomite nanocomposite ceramic filters could be a promising candidate for point-of-use water treatment.
Rapid defluoridation of drinking water by calcium carbonate nanoadsorbent: characterization, adsorption studies and application to real samples’ treatment
Authors: Zawar Masooma , Nazir Rabia , Hamid Almas , Lima Eder C. , Shah Muhammad Raza 
Published: December 2019

Abstract
Groundwater contamination of fluoride is a serious global issue leading to its excessive intake and subsequently numerous adverse health issues. This research was designed to assess the efficiency of nanoadsorbent for removal of fluoride levels from water. For this purpose, calcium carbonate nanoparticles (average particle size 14.6 nm) were prepared and later applied for effective removal of fluoride from simulated as well as real drinking water (DW) samples collected from different areas of Lahore, Pakistan. The particles were characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy/energy-dispersive X-ray spectroscopy, and atomic force microscopy. Physico-chemical parameters were studied in batch mode which revealed high adsorption capacity (i.e. 754.36 mg g−1) at room temperature and neutral pH within 10 min. The kinetic isotherms (general, pseudo-first, and pseudo-second order), diffusion studies (intra-particle diffusion and particle diffusion models), and adsorption models (Langmuir, Freundlich, Liu, and Redlich–Peterson) were also applied to evaluate the suitability of adsorption process. The applicability of nanoadsorbent to fluoride-contaminated real DW samples led to 98–100% efficacy of defluoridation.
A study on the differences in the flocculation of dredged slurries and the influencing mechanisms
Authors: Wu Silin , Zhu Yuyang , Zhu Wei , Shu Shi , Cui Yan 
Published: December 2019

Abstract
In the water treatment process of natural water bodies, a large amount of dredged slurry with high water content is generated and required for treatment. The coagulation–flocculation method can improve the efficiency of separation, and a suitable scheme is of great significance. It is unclear whether there is a significant difference in flocculation and separation of dredged slurries from different sources and which constituents dominate this process. Facing these problems, the tests were conducted for dredged sediments from 10 different sources, including rivers, lake, and ocean. Under the same flocculation conditions, the difference in the increment of particle size d10, the specific resistance of filtration, and the suspended solids (SS) of the supernatant after sedimentation are 0–4.6 times, 0–2.4 orders of magnitude, and 0–4 orders of magnitude, respectively. It was found that the main constituents in the dredged slurries, such as clay minerals, fulvic acid and humic acid, impact on flocculation and separation effects by affecting the zeta potential of the particles. However, there is no single constituent in the dredged slurry which dominates the flocculation and separation effect. When these constituents are incorporated, the zeta potential exhibited in the slurry determines the difference in flocculation and separation effects.
Technology for the development and use of electronic educational resources in the educational process of a university
Authors: Makhmutova M. V. , Senicheva E. I. , Akimova O. A. 
Published: December 2019

Purpose of the study. The aim of the work is to consider the possibility of improving the quality and accessibility of teaching and educational resources through the development and use of electronic educational resources (hereinafter referred to as EER) using the example of the module “System Design”. The article presents a solution to the problem that is of significant importance in the field of information technology implementation in education. The relevance of the research problem is determined by the fact that through the use of interactive tools in the learning process, users, as a rule, a student and an educator, can actively interact with these information tools. Interactivity implies the existence of conditions for educational dialogue, one of the participants of which is a means of informatization of education.Materials and methods. To solve these tasks, the general scientific system approach was used as the main one, the basis of which is to consider educational facilities as systems functioning in a certain environment, as well as methods of analysis and comparison. The study was conducted in accordance with the pedagogical conditions of student learning and the methodological requirements for the educational product. We reviewed methodological recommendations on the use of e-learning in the educational process of the university, the main regulatory documents of distance education technologies in the implementation of additional professional programs, the Moodle distance learning system, guidelines for practical exercises, as well as reference materials on the Moodle system.Results. The study revealed the problem of the use of electronic educational resources, their positive and somewhat negative impact on the goals and results of the educational process, as well as existing technologies for their creation. Based on the analysis of a variety of development technologies for various characteristics, a decision was made to use the LMS Moodle environment. The structure of the module “System Design” was developed, and this module was implemented in the LMS Moodle environment and tested in the educational process, it was revealed that the level of knowledge and skills mastering, as well as their possession is higher among students who studied on the electronic educational resource.Conclusion. Thus, the results of the study allow us to recommend the introduction of electronic educational resources in the learning process. Since the use of the presented development will not interrupt the learning process in cases where the student can not attend classes, and also contributes to improving the formation of students’ competence level.
Medicinal Plants in the Treatment of Peptic Ulcer Disease: A Review
Authors: Ardalani Hamidreza , Hadipanah Amin , Sahebkar Amirhossein 
Published: December 2019

:Peptic Ulcer Disease (PUD) is the most common disorder of the stomach and duodenum, which is associated with Helicobacter pylori infection. PUD occurs due to an imbalance between offensive and defensive factors and Proton Pump Inhibitors (PPI), Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and antibiotics are frequently used for the treatment. Recently, medicinal plants have emerged as efficacious, safe and widely available alternative therapies for PUD. The aim of this review was to study the medicinal plants and phytochemicals, which have been used for PUD treatment to evaluate the potential role of natural compounds to develop herbal remedies for PUD. Information was obtained using a literature search of electronic databases, such as Web of Science, Google Scholar, PubMed, Sci Finder, Reaxys and Cochrane. Common and scientific names of the plants and keywords such as ‘peptic ulcer’, ‘gastric ulcer’, ‘stomach ulcer’ and ‘duodenal ulcer’ were used for search. Eventually, 279 plants from 89 families were identified and information on the plant families, part of the plant used, chemical constituents, extracts, ulcer model used and dosage were abstracted. The results indicated that most of the anti-PUD plants were from Asteraceae (7.1%) and Fabaceae (6.8%) families while flavonoids (49%), tannins (13%), saponins (10%) and alkaloids (9%) were the most common natural compounds in plants with anti-PUD activity.
Association Between Mean Platelet Volume and Hemorrhagic Transformation in Acute Ischemic Stroke Patients
Authors: Wang Changyi , Wang Lu , Deng Linghui , Qiu Shi , Zhang Shihong , Liu Ming , Wu Bo 
Published: December 2019

Background:
Hemorrhagic transformation (HT) is a frequent complication of acute
ischemic stroke (AIS). Mean platelet volume (MPV) is a marker of platelet function. The relationship
between MPV and HT remains unclear.

Methods:
From January 1st, 2012 to December 31st 2016, we consecutively enrolled AIS patients
admitted to the Department of Neurology of West China Hospital. MPV was measured on admission.
HT was diagnosed by brain imaging and classified into hemorrhagic infarct (HI) and parenchymal
hematoma (PH). Moreover, subjects were divided into tertiles according to MPV levels.
Confounders were identified by univariate analysis and multivariate logistic regression was performed
to explore the association between MPV and HT as well as HT subtypes. Also, a generalized
additive model was used to investigate whether a non-linear association existed between MPV and
HT.

Results:
A total of 783 AIS patients were included. 63 patients (8.0%) developed HT: 34 (4.3%)
HI and 29 (3.7%) PH. It was observed that MPV positively correlated with HT. After adjustment
for confounders, patients in the highest MPV tertile had a significantly increased risk of HT compared
to patients in the lowest tertile (odds ratio 2.3, 95% confidence interval 1.0-5.4, P=0.04).
The risk of HT increased step-wise across MPV tertiles (P for trend=0.04). MPV tertiles significantly
correlated with HI rather than PH. The generalized additive model demonstrated a nonlinear
association between MPV and HT (P=0.02).

Conclusion:
The risk of HT increased with increasing MPV level in a dose-dependent manner.
Patients with elevated MPV levels were more likely to develop HI rather than PH.
A New Perspective on the Relation Between Obesity and Knee Osteoarthritis: Omentin
Authors: Gundogdu Gulsah , Gundogdu Koksal , Miloglu Fatma Demirkaya , Tascı Seymanur Yılmaz 
Published: December 2019

Objective:
Knee osteoarthritis (KOA) is defined as a chronic degenerative joint disease.
Obesity is a significant risk factor for KOA. Omentin is an adipose tissue-induced adipokine. The
aim of the present study was to investigate the correlation between obesity and serum omentin levels
in patients with KOA.

Methods:
This study included 60 patients with KOA, 34 obese individuals (O-KOA) and 26 nonobese
individuals (NO-KOA) and 40 controls, 17 obese individuals (OC) and 23 nonobese individuals
(NOC) matched in terms of age, sex, and body mass index (BMI) who were recruited from the
same polyclinic. Blood samples and knee radiographs were obtained from all the subjects, and
clinical features, BMI, and laboratory parameters were recorded. The Kellgren–Lawrence (KL)
grade and Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index were used
to classify the radiographic and clinical findings, respectively. Serum omentin levels were determined
using an ELISA.

Results:
Serum omentin levels in patients were significantly lower than those in the controls (p <
0.05). When the BMI values and KL scores were considered, serum omentin levels significantly
decreased in severe O-KOA versus in mild-to-moderate O-KOA. There was no statistically significant
decrease in severe NO-KOA versus mild-to-moderate NO-KOA. There was a significant negative
correlation between the serum omentin level and BMI and WOMAC index. All findings were
supported by a receiver operating characteristic curve analysis.

Conclusions:
Serum omentin levels were inversely related to obesity and the severity of KOA. The
data indicate that omentin may be a new biomarker of KOA to our knowledge and may aid the diagnosis
of early-stage O-KOA, if our findings are supported by further studies involving much
more samples.
Chemical Properties and Therapeutic Potential of Citral, a Monoterpene Isolated from Lemongrass
Authors: Sharma Sandeep , Habib Shagufta , Sahu Debasis , Gupta Jeena 
Published: December 2019

Background:
Citral is one of the main components of lemongrass oil present at a concentration
of 65-85% approximately and is generally separated by steam refining. It is an important
component in the manufacturing of scents, citrus chemicals, cosmetics, food and pharmaceutical
products.

Objectives:
This article aims at reviewing the published literature to highlight the metabolism, extraction
strategies and therapeutic significance of citral for improving the scope of its application
in the food and pharma industry.

Discussions:
Apart from steam refining, there are other techniques like solvent extraction, supercritical
fluid extraction and ultrasonication by which citral can be extracted and the method of extraction
defines its quality. It is an unstable molecule and undergoes rapid deterioration on exposure
to air. Citral is biosynthesized by the plants through the 5 carbon precursor isopentenyl
diphosphate (IPP) units utilizing two diverse biochemical pathways, acetate– mevalonate (acetate–
MVA) pathway or 2C-methylerythritol-4-phosphate (MEP). Orally Citral was absolutely digested
in the gastrointestinal tract and its metabolism leads to the discharge of metabolites which include
a number of acids and a biliary glucuronide. There is no scientific evidence about the long term
bioavailability of citral in the body and it has no adverse effect on tissue related to its accumulation
and delayed excretion. Citral exhibits various important therapeutic properties like antimicrobial,
antioxidant, anticancer, anti-diabetic and anti-inflammatory.

Conclusions:
Citral is a potent biomolecule with various important biological activities and
therapeutic implications. Strategies are required to increase the stability of citral which could
increase its applications.
Multiple-targets Directed Screening of Flavonoid Compounds from Citrus Species to find out Antimalarial Lead with Predicted Mode of Action: An In Silico and Whole Cell-based In vitro Approach
Authors: Gogoi Neelutpal , Chetia Dipak , Gogoi Bhaskarjyoti , Das Aparoop 
Published: December 2019

Background:
Development of resistance by the malaria parasite Plasmodium falciparum
has created challenges in the eradication of this deadly infectious disease. Hence newer strategies
are adopted to combat this disease and simultaneously, new lead/hit identification is going
on worldwide to develop new chemotherapeutic agents against malaria.

Objective:
In this study, 44 flavonoids found mainly in the fruit juice of Citrus species having traditional
use in malaria-associated fever were selected for in silico multiple-target directed screening
against three vital targets of the parasite namely dihydroorotate dehydrogenase (PfDHODH),
dihydrofolate reductase thymidine synthase (PfDHFR-TS) and plasma membrane P-type cation
translocating ATPase (PfATP4) to find out new lead molecule(s).

Methods:
The in silico screening was carried out using different protocols of the Biovia Discovery
Studio 2018 software and Network analyzer plugin of Cytoscape 3.6.0 followed by in vitro screening
of the best lead.

Results:
After screening, CF8 or luteolin was found to have good binding affinity against
PfDHODH and PfATP4 with –CDocker energy 42.2719 and 33.1447 with respect to their cocrystal
ligands. These findings were also supported by structure-based pharmacophore, DFT (Density
Functional Theory) study and finally by in vitro screening of the lead with IC50 values of 8.23
μm and 12.41 μm against 3D7 (chloroquine-sensitive) and RKL-9 (chloroquine-resistant) strain of
P. falciparum, respectively.

Conclusion:
Our study found a moderately active lead molecule with the predicted mode of action
which can be utilized to design some new derivatives with more safety and efficacy by targeting
the two enzymes.
Prediction of Oral Acute Toxicity of Organophosphates Using QSAR Methods
Authors: Kianpour Mina , Mohammadinasab Esmat , Isfahani Tahereh M. 
Published: December 2019

Aims:
Prediction of oral acute toxicity of organophosphates using QSAR methods.
Background: Prediction of oral acute toxicity of organophosphates (including some pesticides and
insecticides) using GA-MLR and BPANN methods.

Objective:
The aim of the present study was to develop quantitative structure-activity relationship
(QSAR) models, based on molecular descriptors to predict the oral acute toxicity (LD50) of organophosphate
compounds.

Methods:
The QSAR models based on genetic algorithm-multiple linear regression (GA-MLR) and
back-propagation artificial neural network (BPANN) methods were proposed. The prediction experiment
showed that the BPANN method was a reliable model for screening molecular descriptors,
and molecular descriptors obtained by BPANN models could well characterize the molecular
structure of each compound.

Results:
It was indicated that among molecular descriptors to predict the LD50 of organophosphates,
ALOGP2, RDF030u, RDF065p and GATS5m descriptors have more importance than the other descriptors.
Also BPANN approach with the values of root mean square error (RMSE= 0.00168), square
correlation coefficient (R2 = 0.9999) and absolute average deviation (AAD=0.001675045) gave the
best outcome, and the model predictions were in good agreement with experimental data.

Conclusion:
The proposed model may be useful for predicting LD50 of new compounds of similar
class.
BASKIRESİM’DE DENEYSEL ARAYIŞLAR VE ATÖLYE 17
Authors: KILIÇ ATEŞ Selvihan 
Published: December 2019

Toplumların yapılarını şekillendiren deneyler, keşifler ve buluşların yanı sıra günümüz sanatının oluşumunda baş etmenlerden biri teknolojidir. Her yeniliğin bir arayış sonucu ortaya çıktığı gerçekliği ile teknoloji; malzemeyi ve kullanılan araçları farklılaştırarak, sonuca giden yolda belirleyici olmaktadır. Sanatçıyı da, sanatsal üretim sürecinde yeni-deneysel arayışlara iten bu anlayıştır. Eski ve yeni teknolojileri bir araya getirerek geleneksel ve çağdaşın buluşmasına olanak veren sanatsal üretim yöntemlerinden biri olan Baskıresim, deneysel arayışlara fazlasıyla yatkındır. Bu arayışların mimarlarından İngiliz sanatçı S. William Hayter, deneysel uygulamalara olanak veren Atölye 17’nin kurucusudur. Sanatçıların farklı arayışlara teşvik edildiği Atölye 17, düşüncenin varlığının hissedildiği bir yer olarak, günümüz Deneysel Baskıresim anlayışının şekillenmesinde önemli bir role sahiptir. Bu çalışmada; Günümüz Baskıresim Sanatı değerlendirildiğinde katkısı yadsınamayacak olan Atölye17’nin önemi ve merakla şekillenen, yeniyi arayan, hızla değişen ve değişime rağmen değişmeyen yeni arayışların dünyası ele alınmaktadır.
Emprendimiento femenino en México: factores relevantes para su creación y permanencia
Authors: Paz Calderón Yannet , Espinosa Espíndola Mónica Teresa 
Published: December 2019

El objetivo de este documento es identificar los factores más relevantes que contribuyen a la creación y permanencia de empresas encabezadas por mujeres en México, para ello se define el perfil de las mujeres que inician un negocio y las condiciones en las que se suman a esta actividad.
La investigación es descriptiva basada en fuentes estadísticas y documentales, se revisan datos del Instituto Nacional de Estadística y Geografía (INEGI), de la Secretaria del Trabajo y Previsión Social (STPS) y del Instituto Nacional de las Mujeres (INMUJERES). Los resultados muestran, que las mujeres se ha visto afectadas de manera severa por el desempleo y la precariedad del mercado de trabajo, que el emprendimiento femenino surge, principalmente como una manera de hacer frente a la pobreza y marginación de sus familias y no como una forma de hacer uso productivo de recursos materiales, físicos e intelectuales. Por ello, es importante que en la construcción de políticas públicas se consideran las condiciones, las necesidades y las motivaciones que tienen las mujeres para crear sus propias empresas, para que los apoyos gubernamentales impulsen la sobrevivencia y el crecimiento de estos emprendimientos.
Indonesia Islamic Bank Profitability 2010-2017
Authors: Nugroho Lucky , Badawi Ahmad , Hidayah Nurul 
Published: December 2019

This study proposes to determine the board management structure, bad debt, and efficiency of the profitability of the Islamic banks during 2007-2017 period. The quantitative data has been analyzed by using multiple regression analysis to determine the effect of independent variables on the variable dependent. Furthermore, the statistic tools used in the data process is Stata version 13. This study shows that the board of directors of the parent bank has a negative and significant influence on profitability. The problem financing has a negative and significant effect on profitability. Likewise, the ratio of operational costs also has a negative and significant effect on profitability. Thus, the existence of a parent bank's board of management to improve the performance of Islamic banks needs to be considered because it has not been able to provide an optimal contribution. In addition, the significant amount of financing quality and the use of inefficient operational costs have been a problem of improving profits from Islamic banks. Keywords: parent bank, bad debt, efficiency, profitability, Islamic banks
Bank Wakaf Mikro and Creative Economics in Pesantren Buntet
Authors: Zayanie Jehan Maya , Fitria Ahsana , Kamariah Rosidatul 
Published: December 2019

The launch of the Bank Wakaf Mikro (Micro Wakaf Bank/BWM) at the pesantren by the Financial Services Authority (OJK) has received a positive response to realizing economic opportunities in the pesantren. This study aims to examine the role of pesantren in empowering creative economics through the BWM program. This study was conducted by doing in-depth observations and interviews. The researchers gathered data using purposive sampling and snowball sampling techniques. The research findings illustrate the presence of BWM at the pesantren Buntet, Cirebon, West Java, Indonesia has provided a new forum, both for the leaders of the pesantren and the community around the pesantren to carry out their economic potential. Communities surrounding the pesantren argue that BWM has been able to overcome the difficulties in accessing financing needs on a micro-scale. However, the BWM needs to increase the amount of funding and products to follow customers' needs in order to create more promising business variations. Keywords: pesantren, OJK, micro bank, Buntet, Cirebon