bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thermodynamic and transport properties of hydrogen containing streams
Authors: Hassanpouryouzband Aliakbar , Joonaki Edris , Edlmann Katriona , Heinemann Niklas , Yang Jinhai 
Published: July 2020

AbstractThe use of hydrogen (H2) as a substitute for fossil fuel, which accounts for the majority of the world’s energy, is environmentally the most benign option for the reduction of CO2 emissions. This will require gigawatt-scale storage systems and as such, H2 storage in porous rocks in the subsurface will be required. Accurate estimation of the thermodynamic and transport properties of H2 mixed with other gases found within the storage system is therefore essential for the efficient design for the processes involved in this system chain. In this study, we used the established and regarded GERG-2008 Equation of State (EoS) and SuperTRAPP model to predict the thermo-physical properties of H2 mixed with CH4, N2, CO2, and a typical natural gas from the North-Sea. The data covers a wide range of mole fraction of H2 (10–90 Mole%), pressures (0.01–100 MPa), and temperatures (200–500 K) with high accuracy and precision. Moreover, to increase ease of access to the data, a user-friendly software (H2Themobank) is developed and made publicly available.
Die Beratung durch Ethikkommissionen bei einer multizentrischen
Beobachtungsstudie in Deutschland – Aufwand und Kosten
Authors: Breidenbach Clara , Sibert Nora Tabea , Wesselmann Simone , Kowalski Christoph 
Published: July 2020

Zusammenfassung
Ziel der Studie Für die Forschung am Menschen nehmen
Ethikkommissionen (EK) eine unverzichtbare Überwachungs- und
Regulierungsfunktion ein. Bei multizentrischen Beobachtungsstudien werden
neben einem Erstvotum meist lokale Zweitvoten von den EKs der beteiligten
Zentren gefordert. Ziel dieser Analyse ist es, einen Überblick
über die verwendeten Ressourcen und den Prozess für die
Beratung durch EKs bei einer multizentrischen Beobachtungsstudie in
Deutschland zu geben.
Methoden Dazu wurde eine Querschnittsanalyse durchgeführt und
die eingesetzten Ressourcen und Aktivitäten seitens der zentralen
Studienleitung für den Zeitraum April 2018–April 2019
dokumentiert. An der Studie, für die die Beratung der EK eingeholt
wurde, nehmen 106 zertifizierte Darmkrebszentren in 15 Bundesländern
teil.
Ergebnisse Es mussten Anträge bei EKs von 14
Landesärztekammern und 7 Unikliniken eingereicht werden. Es wurden
insgesamt 6305 Euro Beratungsgebühren von den EKs abgerechnet, die
erhobenen Gebühren variierten dabei zwischen 50 und 1400 Euro.
Für die teils mehrfachen Ausführungen der Antragsunterlagen
wurden 2986 Blatt DIN A4-Papier gedruckt. Das zentrale Studienmanagement
wendete ca. 210 Arbeitsstunden auf. Die Bearbeitung erfolgte in allen
Fällen schriftlich und dauerte im Median 32 Tage (Range:
5–177 Tage).
Schlussfolgerung Ein bundeseinheitliches Verfahren für die
Beratung durch EKs für multizentrische Studien könnte den
finanziellen, materiellen und personellen Aufwand deutlich reduzieren und
sollte zukünftig angestrebt werden. Im Sinne ökonomischer
und ökologischer Nachhaltigkeit sollten zudem Online-Verfahren
erwogen werden.
Five-Star Ratings and Managerial Turnover: Evidence from the Nursing Home Industry
Authors: Brickley James A , Lu Susan F , Wedig Gerard J 
Published: July 2020

AbstractThe government-sponsored Five-Star Quality Rating System (FSQRS) aggregates multiple measures of nursing home quality into a standardized overall rating. Previous research has found that the FSQRS affected consumer demand and correspondingly motivated a strategic shift toward competing for higher ratings, most notably among nursing homes in more competitive markets. The primary objective of this article is to provide evidence on whether it produced a complementary change in the weight placed on quality ratings in senior management retention decisions. Using the Florida nursing home administrator files from 2007 to 2013, our analysis reveals that the FSQRS motivated a substantial and significant increase in the sensitivity of administrator turnover to star ratings, particularly in more competitive nursing home markets (JEL I18, L15, J63, G24, G34).
Simpson Grade Revisited – Intraoperative Estimation of the Extent of Resection in Meningiomas Versus Postoperative Somatostatin Receptor Positron Emission Tomography/Computed Tomography and Magnetic Resonance Imaging
Authors: Ueberschaer Moritz , Vettermann Franziska Jill , Forbrig Robert , Unterrainer Marcus , Siller Sebastian , Biczok Anna-Maria , Thorsteinsdottir Jun , Cyran Clemens C , Bartenstein Peter , Tonn Jörg-Christian , Albert Nathalie Lisa , Schichor Christian 
Published: July 2020

Abstract

BACKGROUND
Surgeon's intraoperative estimation of meningioma extent of resection (Simpson Grade, SG) is widely used as a prognostic factor for recurrence. However, the validity of SG is still a matter of debate. In preoperative imaging, 68Ga-DOTATATE/PET-CT has been shown to detect meningioma tissue even more sensitively than magnetic resonance imaging (MRI).

OBJECTIVE
To evaluate the Simpson grading within the framework of modern postoperative imaging techniques (MRI; PET-CT).

METHODS
At first, patients with WHO grade I meningioma, surgical resection, and postoperative 68Ga-DOTATATE/PET-CT within 6 mo after surgery were retrospectively analyzed. Second, an analogous prospective cohort of patients with WHO grade I meningioma was investigated by comparing SG after meningioma removal with postoperative MRI and 68Ga-DOTATATE/PET-CT within 6 mo after surgery.

RESULTS
A total of 37 patients were retrospectively analyzed. In total, 5/8 patients with SG-I and II resections showed tumor remnants according to postoperative PET-CT (SG 62.5% false negative). In the prospective cohort of 52 tumors, PET-CT displayed tracer uptake in 15/37 SG-I or II resections indicating unexpected tumor remnants (SG 40.5% false negative). MRI was false negative in 7 of these 15 cases (MRI 18.9% false negative) (P = .037). Discordant results according to PET-CT were more often found in convexity (40%) and falcine (46.7%) meningiomas than in skull base meningiomas (18.2%).

CONCLUSION
Intraoperative Simpson grading is at risk to underestimate tumor remnants, predominantly in grade I and II resections. Postoperative PET-CT improves detection rates compared to MRI. Prognostic impact of postoperative meningioma remnants according to PET-CT needs to be investigated prospectively.
Mental Health for Sexual and Gender Minority Individuals with Physical or Cognitive Disabilities
Authors: Maroney Meredith R. , McGinley Mallaigh 
Published: July 2020

Abstract
This chapter explores the mental health experiences and needs of sexual and gender minority individuals with disabilities. The authors review the evidence-based research on mental health, highlighting the role of stigma, discrimination, and barriers to care. Autistic sexual and gender minority individuals are used to illustrate the unique experiences of subgroups. Much of the research on this topic is exploratory or descriptive in nature, focused on the experiences of and prevalence rates of individuals from sexual and gender minorities. The chapter concludes with a discussion of future directions for research, and the importance of centering the voices of sexual and gender minority individuals with disabilities in research and practice whenever possible.
Student Movements in Latin America
Authors: Bidegain Germán , von Bülow Marisa 
Published: July 2020

Abstract
Latin American student movements have historically been very active in the region’s political life. However, with the partial exception of historical accounts of the university reform movement and the 1960s protests, the academic literature has not addressed the Latin American student movements from a comparative point of view. Rather, it has mostly focused on national or local case studies. This chapter presents a review of some of the most relevant arguments and concepts of this literature, analyzing the key challenges facing contemporary student movements. It addresses three recurrent dilemmas involving student demands, tactical repertoires, and relations with political institutions. Each of these analyses is grounded in important theoretical debates. The chapter contributes to these debates by highlighting the main conceptual findings of the Latin American literature while discussing the challenges faced by the student movement actors themselves. It turns to examples from campaigns in various countries, especially Venezuela, Chile, Brazil, and Mexico.
Analysis of Mild Traumatic Brain Injury Outpatient Follow-Up
Authors: West Sarah K. , Fletcher Brian , Rollins Allison , Will Jennifer , Rozzell Monica , Burton Josh , Spalding M. Chance 
Published: July 2020

Background:
Mild traumatic brain injury (mTBI) remains a prevalent public health concern. Implementation of an mTBI guideline encouraged screening all patients at risk for mTBI, followed by outpatient follow-up in a “concussion clinic.” This resulted in an increase in inpatient concussion evaluations, followed by high-volume referral to the concussion clinic. This prompted the routine use of an outpatient mTBI symptom screening tool. The purpose of this quality improvement study was to analyze the characteristics of an mTBI population at outpatient follow-up and describe the clinicians' care recommendations as determined through the use of an mTBI symptom screening tool.

Methods:
This is a retrospective review of mTBI patients at a Level 1 trauma center. The study includes patients who completed a concussion screening in the outpatient setting over a 6-month period. Patients were included if older than 16 years, sustained blunt trauma, and had a formal neurocognitive evaluation by a certified speech therapist within 48 hr of initial injury.

Results:
Of the 247 patients included, 197 (79.8%) were referred to the concussion clinic, 33 (13.4%) had no further outpatient needs, and 17 (6.9%) were referred for outpatient neurocognitive rehabilitation. On follow-up, 97 patients were deemed to have no further postconcussion needs by the trauma nurse practitioner; 57 patients were cleared by the speech therapist. In total, 43 outpatient mTBI follow-up encounters resulted in referral for ongoing therapy.

Conclusion:
Routine screening for concussion symptoms and detailed clinical evaluation allows for prompt recognition of further posttraumatic mTBI needs.
Fully Implantable Active Middle Ear Implants After Subtotal Petrosectomy With Fat Obliteration: Preliminary Clinical Results
Authors: Lasurashvili Nikoloz , Lailach Susen , Seidler Hannes , Bornitz Matthias , Neudert Marcus , Zahnert Thomas 
Published: July 2020

Objectives:
In patients with chronic middle ear disease, especially after revision surgery for ventilation problems and mixed hearing loss, active middle ear implants may provide an alternative treatment option. The fully implantable active middle-ear implant (FI-AMEI) is designed for implantation in a ventilated mastoid with an intact posterior canal wall. Until now, there have been no reports on audiometric results after implantation of a FI-AMEI in a fat-obliterated cavity after subtotal petrosectomy (SPE).

Study Design:
Retrospective case review.

Setting:
Tertiary referral center.

Patients:
Twelve patients were included after numerous previous tympanoplasty surgeries for severe mixed hearing loss and FI-AMEI implantation.

Intervention:
In five patients, the FI-AMEI was implanted in a cavity, with fat obliteration, after SPE. Seven patients received FI-AMEI implantation after intact canal wall (ICW) surgery.

Main Outcome Measure(s):
Audiometric results (pure-tone audiometry, Freiburger monosyllables) are demonstrated for 12 patients after an observation period of 3 months.

Results:
The improvement in monosyllable score was 40 to 85% for the 12 patients. Free-field-aided thresholds showed high heterogeneity.

Conclusion:
FI-AMEI implantation combined with SPE provides an alternative approach to hearing rehabilitation to non-FI-AMEI implantation. Studies with a high number of patients and long-term observation periods are necessary to statistically verify these results.
Efficacy of acupuncture and moxibustion in adjuvant treatment of patients with novel coronavirus disease 2019 (COVID-19)
Authors: Zhang Qiongshuai , Xu Xiaohong , Sun Shaoqian , Cao Fang , Li Jiannan , Qi Xun , Ji Guangcheng , Wang Yufeng , Song Bailin 
Published: July 2020

Abstract

Background:
Novel coronavirus has infected 4.33 million people in more than 200 countries in the current global outbreak of COVID-19. However, there is still no effective drug to treat the disease, and acupuncture and moxibustion is utilized as adjuvant therapy for the treatment of COVID-19 in China.

Methods:
Nine electronic databases: PubMed, EMBASE, Cochrane library, Web of Science (WOS), Google Scholar, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), Chinese Scientific and Journal Database (VIP), Wan Fang database (Wanfang) and 2 clinical trials register platforms: Chinese Clinical Trial Registry (ChiCTR), ClinicalTrials.gov (www.ClinicalTrials.gov/) will be searched for RCTs of A&M for COVID-19. The screening process will be developed by 2 independent reviewers, and meta-analysis will be performed with RevMan (V5.3.5) software.

Results:
The study results will be contributed to a scientific journal after peer-reviewed for publication.

Conclusion:
The study will provide up-to-date evidence of the effectiveness and safety of A&M for patients with COVID-19.

PROSPERO registration number:
CRD42020185776
In vivostructural characterization of the whole SARS-CoV-2 RNA genome identifies host cell target proteins vulnerable to re-purposed drugs
Authors: Sun Lei , Li Pan , Ju Xiaohui , Rao Jian , Huang Wenze , Zhang Shaojun , Xiong Tuanlin , Xu Kui , Zhou Xiaolin , Ren Lili , Ding Qiang , Wang Jianwei , Zhang Qiangfeng Cliff 
Published: July 2020

SUMMARYSARS-CoV-2 is an RNA virus of theCoronaviridaefamily that is the causal pathogen of the ongoing Coronavirus Disease 2019 pandemic. There are currently no antiviral drugs or vaccines to treat COVID-19, and the failure to identify effective interventions can be blamed on our incomplete understanding of the nature of this virus and its host cell infection process. Here, we experimentally determined structural maps of the SARS-CoV-2 RNA genome in infected human cells and also characterizedin vitrorefolded RNA structures for SARS-CoV-2 and 6 other coronaviruses. Ourin vivodata confirms several structural elements predicted from theoretical analysis and goes much further in revealing many previously unknown structural features that functionally impact viral translation and discontinuous transcription in cells. Importantly, we harnessed ourin vivostructure data alongside a deep-learning tool and accurately predicted several dozen functionally related host cell proteins that bind to the SARS-CoV-2 RNA genome, none of which were known previously. Thus, ourin vivostructural study lays a foundation for coronavirus RNA biology and indicates promising directions for the rapid development of therapeutics to treat COVID-19.HIGHLIGHTSWe mapped thein vivostructure and built secondary structural models of the SARS-CoV-2 RNA genomeWe discovered functionally impactful structural features in the RNA genomes of multiple coronavirusesWe predicted and validated host cell proteins that bind to the SARS-CoV-2 RNA genome based on ourin vivo RNAstructural data using a deep-learning tool
Empowering lifelong learning through open universities in Taiwan and Indonesia
Authors: Zuhairi Aminudin , Hsueh Amy Ching Tsu , Chiang I-Chin Nonie 
Published: July 2020

PurposeThis research attempts to reveal ways of addressing challenges in open universities related to empowering lifelong learning; establishing policies and strategies in dropouts, student portfolio and support services for students with special needs; and implementing online instructional design and strategies. Two institutions were investigated, namely National Open University (NOU) Taiwan and Universitas Terbuka (UT) Indonesia, both founded in the 1980s to serve lifelong learners with diverse backgrounds and needs. This study was aimed at understanding good practices and challenges for improvement for the two open universities in those areas being investigated.Design/methodology/approachThis research was qualitative using document analysis along with focus group discussions and interviews with administrators, academic staff, students and alumni to collect data for analysis.FindingsLifelong learning is the necessity of individual in societies for continuing professional development through enabling access to quality university education. Open universities have been tasked to cater for lifelong learners using non-traditional approaches, new technology and adapting to online learning and teaching in digital age. This research was exploratory, and the findings were expected to improve understanding of lifelong learning in open universities, particularly in NOU and UT.Practical implicationsFindings of this research are relevant to open universities to enhance its missions and define its possible new roles to serve lifelong learners.Originality/valueThis research reveals the roles of open universities in lifelong learning and enhances understanding of open universities that have a wide range of responsibilities in offering programs and courses to accommodate lifelong learners.
Extreme rainfall trends over the Mekong Delta under the impacts of climate change
Authors: LEE Seung Kyu , Dang Truong An 
Published: July 2020

PurposeThis study aims to investigate aspects related to the changing trends of the rainfall extremes in the entire Mekong Delta in the period of 32 years (1984-2015) applying rainfall extreme indices. First, the homogeneity tests were applied to assess the quality of observed rainfall data series. The authors, then, investigated three rainfall indices including the number of very heavy rainfall days 20 mm (R20), number of days above 50 mm (R50) and number of days above 100 mm (R100) applying the Mann-Kendall test and Sen’s slope estimate.Design/methodology/approachFirst, the homogeneity tests were applied to assess the quality of observed rainfall data series. The authors, then, investigated three rainfall indices including the number of very heavy rainfall days 20 mm (R20), number of days above 50 mm (R50) and number of days above 100 mm (R100) applying the Mann-Kendall test and Sen’s slope estimate.FindingsThe results of R20 pointed out that an insignificant upward tendency was found in the coastal provinces, whereas an insignificant downward tendency was also recorded in the inland provinces. Regarding the number of R50, a similar trend to R20 was recorded with five stations slightly increased and five stations slightly decreased. For the number of R100, the results recorded an absence of significant trends over the entire study area. Approximately 58.5% of stations show a slightly decreasing trend, while 41.5% of the remaining stations recorded a slightly increasing trend.Originality/valueFor the number of R100, the results recorded an absence of the significant trends over the entire study area. Approximately 58.5% of stations show a slightly decreasing trend, while 41.5% of the remaining stations recorded a slightly increasing trend. Of note is the fact that the number of R100 occurred more frequently in the northern provinces, which means the northern region is facing a high risk of flooding.
Product value analysis: a developed cost–benefit analysis ratio based on the Kano and PAF models
Authors: Janatyan Nassibeh , Shahin Arash 
Published: July 2020

PurposeIn this study, an integrative approach of customer satisfaction and cost of quality has been proposed for the value analysis of products based on a cost–benefit ratio.Design/methodology/approachFor the integrative approach, Kano and prevention-appraisal-failure (PAF) models have been applied. By the proposed approach, the value of products can be analyzed according to customer viewpoints and cost of quality. Four products of a home appliance company have been used to examine the new approach.FindingsFindings indicate the priorities of the studied products as stove, TV, fridge and washing machine, respectively. Such a set of prioritized products plays a strategic role in the competitive advantage of the studied company.Research limitations/implicationsIn this study, the weights of the cost of quality items have been assumed as equal. Also, the costs of quality items were limited to the most important ones at the studied company. However, more cost of quality items might be considered in different case studies.Originality/valueIn this study, the Kano and PAF models have been considered simultaneously for product value analysis from the viewpoint of customers. In addition to the classic method of value analysis which is merely based on previous events, the proposed approach is typically proactive.
Determination of retinal nerve fibre layer and ganglion cell/inner plexiform layers progression rates using two optical coherence tomography systems: The PROGRESSA study
Authors: Saks Danit , Schulz Angela , Craig Jamie , Graham Stuart ,   the PROGRESSA Study Group
Published: July 2020

AbstractImportanceGlaucoma progression rates may differ depending on the retinal structural parameters measured, and between devices.BackgroundTo compare retinal nerve fibre layer (RNFL) and ganglion cell/inner plexiform layers (GCL/IPL) progression rates using two spectral‐domain optical coherence tomography (OCT) systems.DesignProspective, university hospital setting.ParticipantsCross‐sectional study: 100 eyes from 53 glaucoma suspects and early manifest glaucoma cases. Longitudinal study: subset of 61 eyes from 33 participants.MethodsSame day optic nerve and macular images were acquired using Cirrus and Spectralis systems from which RNFL and GCL/IPL thicknesses were calculated. Longitudinal analysis of RNFL and GCL/IPL progression rates was calculated from 6 × 6‐monthly follow‐up OCT scans.Main Outcome MeasuresRNFL and GCL/IPL thicknesses in matched superior, inferior and global regions were compared by both systems cross‐sectionally and longitudinally.ResultsAt baseline, no RNFL thicknesses differed between devices. Cirrus GCL/IPL regions were significantly thicker than Spectralis (P < .001). RNFL and GCL/IPL global progression rates (μm/y) had a mean (SD) of −1.28 (1.11) and 95% CI: (−1.48, −1.09) and −0.51 (0.58) and 95% CI: (−0.62, −0.41), respectively. Progression rates were similar across devices. RNFL loss (%) progressed significantly faster than GCL/IPL, in all regions (P ≤ .004).Conclusion and RelevanceDespite baseline thickness differences, overall Cirrus and Spectralis provided similar rates of RNFL and GCL/IPL progression in early glaucoma and can be considered comparable, though not interchangeable, in clinical practice. Further analysis is needed to determine if RNFL progresses faster than GCL/IPL in glaucoma, and whether one precedes the other.