bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ischaemic postconditioning reduces peroxide formation, cytokine expression and leukocyte activation in reperfusion injury after abdominal aortic surgery in rat model
Authors: Sínay L. , Kürthy M. , Horváth Sz. , Arató E. , Shafiei M. , Lantos J. , Ferencz S. , Bátor A. , Balatonyi B. , Verzár Zs. , Sütő B. , Kollár L. , Wéber Gy. , Rőth E. , Jancsó G. 
Published: December 2019

Objective: We studied the protective effects of ischaemic postconditioning (PS) on ischemia–reperfusion injury of the lower extremities in a rat model of abdominal aortic intervention. We aimed to examine the evoked oxidative stress, cytokine expression and leukocyte activation after revascularisation surgery. Methods: Anesthetized animals (48 Whistar rats) underwent a 60 min infrarenal aorta cross-clamping. After the ischaemic period, an intermittent 4 times 15 s reperfusion – 15 seconds ischaemic episodes – were applied (ischaemic postconditioning: group PS). Then we started a 120 min reperfusion in the aorta. In untreated group animals underwent a long ischaemia (60 min) and the following reperfusion (group IR). Peripherial blood samples were collected before operation, and in early (5, 10, 15, 30, 60 and 120 min) reperfusion periods. Serum peroxide level, TNF-alpha concentration, myeloperoxidase (MPO) activity and PMA-induced leukocyte ROS production were measured. Results: In PS group, plasma peroxide level elevation was significantly lower in very early reperfusion (5–30 min) comparing to non-conditioned IR group (10.04±1.9 μM/l vs. 16.91±3.67 μM/l, p<0.05). PS also reduced serum TNF-alpha concentration (167.41±31.26 μg/ml vs. 116.55±12.04 μg/ml, p<0.05), MPO activity (1.759±0.239 μM/ml vs. 1.22±0.126 μM/ml, p<0.05) and leukocyte activation detected by PMA-induced leukocyte ROS production (5.7±0.96 AU/103 cells vs. 4.63±0.69 AU/103 cells). Conclusions: Ischaemic postconditioning could reduce ROI production after IR in early reperfusion period, thus limiting ROI mediated tissue lesion, cytokine–leukocyte activation and inflammatory responses. PS seems to be an effective tool in vascular surgery to reduce reperfusion injuries after revascularization interventions.
Non-neuronal cholinergic system and signal transduction pathways mediated by band 3 in red blood cells
Authors: Carvalho Filomena A. , Almeida José Pedro , Fernandes Isabel O. , Freitas-Santos Teresa , Saldanha Carlota 
Published: December 2019

Background: Non-neuronal acetylcholine (ACh) and acetylcholinesterase (AChE) have been recognized in the past. Vascular ACh has been associated by us with the regulation of microcirculatory flow by modulating nitric oxide (NO) intracellular mobilization, metabolism (NOx) and release from erythrocytes, as well as the glycolytic flux. Velnacrine maleate is a well-known AChE inhibitor which plays a competitive role by decreasing NO-mediated erythrocyte responses. A plausible hypothesis to explain the mechanisms underlying those events hinges on the NO translocation among nitrosylated molecules and phosphorylated/dephosphorylated states of band 3 protein, processed by major tyrosine-kinases (PTK: p72syk, p53/56lyn and p59/61hck) and phosphotyrosine-phosphatases (PTP). Methods: To assess this hypothesis under the influence of AChE effectors (acetylcholine/velnacrine), blood samples from healthy donors were harvested and Western blot analysis was subsequently used to determine the degree of band 3 phosphorylation, in the presence and absence of PTK/PTP inhibitors. NO and nitrites/nitrates were quantified using an amperometric method and the Griess Reaction, respectively, in erythrocyte suspensions. Measurements of erythrocyte metabolites (2,3-bisphosphoglycerate; glyceraldehyde 3-phosphate dehydrogenase; glucose-6-phosphodehydrogenase; lactate), hemoglobin and cyclic nucleotides were conducted afterwards. Results: Increased levels of phosphorylated-band 3 obtained upon p72syk inhibition suggest p59/61hck and p53/56lyn as secondary involved kinases. As to NO/NOx quantification, in the presence of PTKi we reported higher levels with velnacrine-AChE, as opposed to acetylcholine-AChE. Calpeptin, a PTP inhibitor which triggers full band 3-phosphorylation, led to the opposite NO mobilization, being reinforced by ACh. Oxy-hemoglobin, glyceraldehyde 3-phosphate dehydrogenase and glucose-6-phosphodehydrogenase were found to decrease with ACh, whereas P50, lactate and both cGMP/cAMP happened to increase. Conclusion: Changes on human erythrocyte NO(x) mobilization and metabolic fluxes occur under influence of non-neuronal ACh/AChE, in turn dependent on the degree of band 3-phosphorylation. Since these vascular events may potentially change under pathological conditions, coadjuvant drugs could become accessible in the setting of microcirculation disease.
Hemorheological changes after intravenous gammaglobulin administration in patients with neurological disorders
Authors: Kowal Piotr , Zmyślony Anna 
Published: December 2019

Hemorheological changes due to intravenous gammaglobulin (IVIg) administration have been considered to influence blood viscosity and this way the blood flow in microcirculation. The study was carried out in the group of 10 patients with various neurological disorders (seven with polyradiculoneuropathy, two suffering from myasthenia and one with multiple sclerosis). Patients were treated routinely with intravenous gammaglobulin infusion (Sandoglobulin, Sandoz, 24 g a day in the course of 5 days therapy). The following hemorheological factors were estimated: relative blood viscosity, plasma viscosity, red cell deformability and erythrocytes aggregation. For rheological examination the microviscosimeter Low Shear 40 (Contraves) was used. Each patient was examined two times: before treatment initiation and at the end of therapy after five days. At the comparison of first and last measurements a significant increase of plasma viscosity (p<0.04) was found, whereas erythrocyte deformability was significantly improved (p<0.05). The value of relative blood viscosity at shear rate of 0.1 s−1 was significantly decreased (p<0.05) and statistically unchanged at other studied shear rates. The results suggest an existence of a protective feedback mechanism in the studied group of patients which has been exemplified by the red cell elasticity improvement.
Contrast-enhanced ultrasound in liver transplant: First results and potential for complications in the postoperative period
Authors: Clevert D.-A. , Stickel M. , Minaifar N. , Löhe F. , Graeb C. , Jauch K.W. , Reiser M. 
Published: December 2019

Purpose: This study compared the efficacy of contrast-enhanced ultrasound (CEUS) using a second generation contrast medium versus CT or MRA in the assessment of vascular and biliary complications in postoperative follow-up of liver transplantation. Methods and materials: The study group consisted of 36 consecutive liver transplant recipients who underwent post-transplantation CEUS examination after developing ascites and/or unclear liver function tests. Real time CEUS was performed after a bolus injection of SonoVue® (1.6–2.4 ml, Bracco, Imaging Germany) followed by 10 ml of saline solution. Using contrast harmonic imaging (CHI) technique (Logiq 9, GE) with a 2.5–4-MHz transducer, a low mechanical index was chosen to avoid early destruction of the microbubbles (MI 0.1–0.2). In order to confirm the results, the patients underwent contrast-enhanced MRI or CT. Results: Complications were identified in 16 of 36 patients (44.4%). Five transplants (14%) had hepatic artery thrombosis (n=2) or significant stenosis (n=3). Six transplants (16%) developed portal vein stenosis (n=4) or portal vein thrombosis (n=2). MRI or CT confirmed the findings of the CEUS in all 11 cases. Biliary stricture at the anastomotic site was detected in 5 patients. MR-CP confirmed the findings of all strictures. Conclusion: Due to advances in contrast-enhanced US, vascular and biliary complications in the postoperative period following liver transplantation can be reliably diagnosed non-invasively on the intensive care unit. CEUS shows vascular as well as biliary complications in the postoperative patient with a high degree of accuracy.
Contrast harmonic imaging ultrasound and perfusion imaging for surveillance after endovascular abdominal aneurysm repair regarding detection and characterization of suspected endoleaks
Authors: Pfister K. , Rennert J. , Uller W. , Schnitzbauer A.A. , Stehr A. , Jung W. , Hofstetter P. , Zorger N. , Kasprzak P.M. , Jung E.M. 
Published: December 2019

Objective: Is Contrast Harmonic Imaging (CHI) comparable to computed tomography angiography (CTA) scan in detecting and characterizing suspected endoleaks after endovascular abdominal aneurysm repair in a non-selected group including reintervention procedure and branched endografts in daily practice? Material/methods: In a prospective study computed tomography angiography (CTA) and contrast-enhanced ultrasound (CEUS) were performed in 30 consecutive patients (26 males, 4 females, mean age: 72 years, range: 38–87) with suspected endoleaks in follow-up (mean 13 months, range: 1–95) after endovascular abdominal aneurysm repair or procedure in dissection or penetrated ulcer of the aorta (25 infrarenal, 5 suprarenal stent grafts, mean aortic diameter 56 mm, range: 27–98). CTA was supposed to be gold standard for determining the presence of endoleaks (multislice CT, collimation 16 × 0.75 mm, 100 ml of iodized contrast agent bolus). Ultrasonography used a multi-frequency probe (1–4 MHz) with the modalities of colour coded Doppler sonography (CCDS), power Doppler (PD) combined with contrast enhancement and the technique of contrast harmonic imaging (CHI) and low mechanical index (MI < 0.2). 2.4 ml of SonoVue® (Bracco, Altana Pharma GmbH, Italy) were administered to each patient intravenously as a bolus injection. Results: Out of 30 patients, 21 endoleaks were identified in CTA (6 type I or III, 15 type II), 22 in CHI. Thus, sensitivity for CHI was therefore 99%, its specificity 85% (Spearman correlation coefficient (CC) 0.92). In follow-up the localizations of endoleak type I or III exclusively detected by CHI were confirmed as true positive by angiography. Due to its dynamic characteristic CHI seemed to be more helpful in characterization of endoleaks than CTA. In case of a rupture after reintervention a type III endoleak leads to prompt intervention before receiving the result of the CT scan. Altogether, CHI failed to identify 1 combined type I and II endoleak (sensitivity 0.99). Both, CCDS and PD were positive only in 6/30 patients (CC 0.33 and 0.39). Interestingly the application of contrast agent doubles the detection rate of endoleaks (12/30) in CCDS and PD (CC 0.39). Conclusion: Contrast harmonic imaging (CHI) compared to computed tomography angiography (CTA) accurately depicts endoleaks after endovascular abdominal aneurysm repair and stent-graft procedure in dissected and ulcerated aorta. It seems to be superior in characterization of the type of endoleaks and can be established in order to reduce iodized contrast agent and radiation exposure in follow-up. In contrast to CTA scan CHI can be offered to patients with chronic renal insufficiency and allows a dynamic examination and a perfusion analysis.
The Relationship Between Vocabulary Mastery and Reading Comprehension: An Assessment Prespective
Authors: Qomar Aulia Hanifah , Sari Maysara Devilia 
Published: December 2019

In reading comprehension has some factors that influence the skill. One of the factors is vocabulary mastery. The objective of this research is to know whether there is any correlation between vocabulary mastery and reading comprehension and the degree of correlation. The total of the participants of this research was 30 students in VII A of the seventh grade students of SMPN 7 Metro. Cluster random sampling technique was used to get the sample. A correlatinal analysis was employed to know the relationship between scores in the reading comprehension and vocabulary mastery test. Based on the research calculation by using correlation product moment, it was obtained that is 0,462, and is 0,367 in significant 5% and 0,470 in significant 1%. The average of vocabulary mastery was 61,6. The finding also indicate that the students’ achievement in the vocabulary was poor. The average score of reading comprehension was 62,4. It means that the students’ achivement in the reading comprehension was fair. Therefore, the findings provide that there was a positive correlation between vocabuary mastery and reading comprehension of the seventh grade students of SMP N 7 Metro.
Salivary pH and Taste Sensitivity among Geriatric and Non-Geriatric Patients in a Tertiary Hospital: A Cross Sectional Study
Authors: Crisostomo Miguel , Ureta Celso 
Published: December 2019

Objective: To evaluate the association of salivary pH and taste sensitivity among geriatric and non-geriatric patients in an otorhinolaryngology - head and neck surgery out-patient clinic.
Methods:
Design: Cross-Sectional Study
Setting: Tertiary Government Training Hospital
Participants: 40 otorhinolaryngology out-patients

Results: Of the 40 patients aged 24 to 92-years-old (mean age 59.8 years), 21 were geriatric and 19 were non-geriatric. The mean salivary pH was 6.66 (range 5 to 8) and 6.63 (range 5 to 7) for geriatric and non-geriatric groups; the difference in mean salivary pH was not statistically significant (p = .87). The salivary pH in the geriatric group showed a negative correlation with age (r=0.06), while the salivary pH in the non-geriatric group had a positive correlation with age (r=0.14). Overall, increases in age among the non-geriatric group were correlated with increase in salivary pH which were not observed in the geriatric patients. In the geriatric group, among the 4 tastants, the strongest correlation between taste sensitivity and salivary pH was observed for quinine followed by sucrose and NaCl, but no correlation for citric acid. In the non-geriatric group, the strongest correlation between taste sensitivity and salivary pH was observed for NaCl, followed by quinine, citric acid and sucrose.
Conclusion: There was no significant difference between the mean salivary pH of geriatric and non-geriatric patients, and both means were within normal. There was a negative correlation between age and salivary pH in the geriatric group, and a positive correlation in the non-geriatric group. Salivary pH had the strongest correlation with taste sensitivity for quinine and NaCl among geriatric and non-geriatric participants, respectively, but the reasons for, and significance of this cannot be inferred from the present study.
Keywords: salivary pH; taste sensitivity; gustatory function; geriatric
Kikuchi-Fujimoto Disease in a Filipino Boy: A Case Report
Authors: Escalderon Jenina Rachel , Monroy Angelo 
Published: December 2019

Objective: To report a case of a 12-year-old boy with Necrotizing Lymphadenitis (Kikuchi-Fujimoto disease) presenting as lymphadenitis secondary to multiple diagnosis.

Methods:
Design : Case Report
Setting: Tertiary Private Hospital
Patient: One

Results: A 12-year-old boy consulted for two-month history of cervical lymphadenopathy with the underlying cause remaining unclear despite multiple consults, diagnosis and medical treatment. Lymphoma was considered and excision biopsy with further investigations confirmed a diagnosis of Kikuchi-Fujimoto disease. Supportive management was given with no recurrence of symptoms noted on 18 months of follow up.

Conclusion: Kikuchi-Fujimoto disease in this case was a diagnosis of exclusion. Even with a proper history and physical examination, experts in otolaryngology can be misled to manage this case as malignant. Awareness of the disease and appropriate examinations including immunohistochemistry are important for a timely diagnosis and proper intervention.

Keywords: lympadenitis; Kikuchi-Fujimoto disease; lymphoma; cervical lymph nodes
ÜLKEMİZ GİRİŞİMCİLERİ İÇİN YENİ BİR YATIRIM DESTEĞİ MODELİ: INITIAL COIN OFFERING (ICO)
Authors: TETİK Nevzat , ÖNER Ahmet 
Published: December 2019

Dünyanın genelinde özellikle uluslararası rekabette yer almak isteyen girişimcilerin en önemli sorunlarından birisi zamanında, yeterli düzeyde ve minimum maliyetli finansal fon kaynakları temin edememe handikapıdır. Söz konusu bu sorunların ve yetersizliklerin çözümü için dünyada son yıllarda geliştirilen yeni bir model Initial Coin Offering (ICO)’dir. Türkçe karşılığı kripto para arzı olarak ifade edilebilen ICO modelinin teorik altyapısı 1998 yılında Wei Dai tarafından oluşturulmuştur. Sistemin teknik altyapısı 2008 yılında Satoshi Nakamoto isimli bir birey ya da topluluk tarafından geliştirilmiştir. Kripto para sisteminin yasal açıdan herhangi bir otoriteye bağlı olmaması sistemin kısa sürede yaygınlaşmasını sağlayan bir etken olmuştur. Ayrıca girişimciler açısından değerlendirildiğinde, yüksek getiri oranlarının söz konusu olması, işlem maliyetlerinin diğer yatırım araçlarına göre daha düşük seviyelerde olması ve transferin kolay yapılabilmesi gibi nedenler kripto para sistemine olan talebin artmasını sağlamıştır. Finans dünyası açısından önemli bir değişim ve yatırım aracı olarak kullanılan bu sistemin işlem hacminin her geçen gün artıyor olması sistemin tüm boyutları ile ayrıntılı olarak incelenmesini zorunlu kılmaktadır. Bu çalışmada, dünyada kripto para ve arzı hakkında genel olarak bilgilere yer verilerek ülkemizde kripto para arzının tanınabilmesi, tanımlanabilmesi, gerekli görülen tedbirlerin alınabilmesi, fırsatlardan yararlanılabilmesi ve sistemin sağlıklı bir şekilde uygulanabilmesi için değerlendirmeler yapılıp öneriler geliştirilmeye çalışılmıştır. Bu bağlamda, Hem dünyada hem de Türkiye’de özellikle dev projelerde finansal kaynak ve yatırım aracı olarak hızlı bir yönelim ve büyüme trendinde olan kripto paralarının kullanılması fırsatının iyi değerlendirilmesi, gerekli regülasyon ve revizelerle yasal düzenlemelerin ivedilikle yapılarak etkin bir denetim sisteminin tesis edilmesi son derece önemlidir. Ayrıca çoğu kripto para kullanıcısının, teknolojinin yeni olmasında kaynaklanan bilgi ve tecrübe eksiklerinin giderilmesi amacıyla konunun uzmanları tarafından bilgilendirme ve tanıtım toplantılarının süreklilik arz edecek şekilde yapılması, tanıtıcı broşür ve kitapçıkların dağıtılması faydalı olacaktır.
SOCIALIZATION OF THE USE OF GROUNDWATER IN THE SOUTH MERUYA REGION OF WEST JAKARTA
Authors: Hidayat Acep , Suprapti Suprapti , Aly Soh 
Published: December 2019

With the growth of the city every year, it changes the composition of land use. City growth that occurs in line with the development of population, social activities and industrial activities that accompany it, resulting in increased demand for land availability that will be used to carry out various activities. The availability of land as a media for water absorption is decreasing while the use of ground water is continuously being explored to meet the needs of the community, social activities and industrial activities. Structure and texture as well as other organic elements take part in increasing the rate of soil permeability The use of ground water by the community and social activities is not greater than the use by industrial activities. At present, especially large cities with very rapid development of industrial activities are causing large groundwater usage. With the decreasing availability of infiltration land, making the process of water entering the soil less and less, if this happens continuously in the long run, it will cause a decrease in the ground water level, a decrease in land elevation, and easy sea water instruction. Therefore it is necessary to socialize to the public about the use of ground water so that the condition of groundwater is maintained.
EMPOWERING COMMUNITIES THROUGH CREATION OF MURAL ART AS AESTHETIC SUPPORT IN ‘KEDAI OMAH JLAMPRANG’ PEKALONGAN
Authors: SW Hagung Kuntjara , Tobroni Muhammad Imam 
Published: December 2019

Krapyak Village - Pekalongan, is currently improving itself to become a tourist destination based on the carrying capacity of Geographical, Cultural, Human Resources owned, including; Slamaran Beach, Batik Industry with typical motifs of Jlamprang, Culinary specialties of Pekalongan, and community human resources who will be trained in their independence. Community Development Academic (CDA) - Binus University facilitates the transfer of knowledge from lecturers from various interdisciplinary disciplines to be applied directly to the community or community that requires capacity building in connection with the preparation to develop tourist destinations. Through a long collaboration and discussion between the campus and the government of Krapyak - Pekalongan Urban Village, it was decided to build a culinary shop where joint learning could serve typical Pekalongan meals, outlets selling batik and handicraft products of SMEs, as well as a convenient spot for community gathering to build understanding of tourist area preparation. Through training programs on the physical building architecture of the shop, Interior Design settings and selection of equipment for chairs and souveneer creation training, mapping of tourist attractions, culinary training in making menus and cooking, Management of shop and financial management. Visual Communication Design plays a role in thecreation of identity branding, starting from naming 'Kedai Omah Jlamprang' and its completeness and Mural Art to build a cozy atmosphere of a shop through the work of aesthetic elements that have meaning. All of these training programs involve discussions and practical workshops on product creation that involve lecturers and SME communities in the Krapyak - Pekalongan village, so that the objectives of the Fostering & Empowering Society can occur. It is hoped that this process will build trust and desire to grow economic independence in the community.
PENERAPAN MODEL PEMBELAJARAN STUDENT TEAM ACHIEVEMENT DIVISIONS (STAD) DAN NUMBER HEAD TOGETHER (NHT) TERHADAP HASIL BELAJAR SISWA
Authors: Murniati Neni , Lestari Ance Villa , Irwandi Irwandi 
Published: December 2019

Penelitian ini bertujuan untuk mengetahui perbedaan hasil belajar siswa pada pembelajaran biologi dengan menggunakan model pembelajaran Student Team Achievement Divisions (STAD) dan Number Head Together (NHT) pada kelas yang berbeda SMPN 3 Kota Bengkulu. Penelitian ini dilakukan dengan metode Kausal Komparatif. Design penelitian ini menggunakan design Nonequivalen Control Group Design. Sampel dalam penelitian ini adalah siswa kelas VIII yang diambil 2 kelas yang ditetapkan secara acak (random sampling). Kelas pertama dengan menggunakan pembelajaran STAD dan kelas kedua dengan NHT. Pengumpulan data penelitian menggunakan instrumen berupa soal kemampuan hasil belajar kognitif. Analisis data menggunakan Uji t (uji hipotesis). Data hasil penelitian menunjukkan bahwa rata-rata hasil belajar biologi siswa menggunakan model pembelajaran STAD (84,44) lebih tinggi dibandingkan nilai rata-rata hasil belajar siswa menggunakan model NHT (78,51).