bluuebunny/crossref_metadata_2025_split huggingface dataset:
Active Radar Cross Section Reduction of an Object Using Microstrip Antennas
Authors: Sengupta Sohini , Council Henry , Jackson David R. , Onofrei Daniel 
Published: February 2020

AbstractThe research performed in this paper suggests that the radar cross section of an arbitrarily shaped object can be reduced by canceling the scattering from the object with the radiation from an antenna (implemented here as a microstrip antenna) placed on the surface of the object. Assuming that the direction of arrival of the incident signal is known, the radiation from the defending antenna can be adjusted in real‐time to cancel the scattering from the object in order to produce a negligible total field at the distant receiver so that the object becomes invisible to a monostatic radar working in a given known frequency band. This is implemented using an analog sensor on the object to measure the time domain field on the object, which is then connected to the antenna through an amplifier and phase shifter to control the radiation from the patch antenna. The system is implemented in real time and does not require any digitization or signal processing. The radar cross section reduction can thus be achieved with a wide variety of incident signals in the prescribed frequency band.
When Plasma Streams Tie up Equatorial Plasma Irregularities with Auroral Ones
Authors: Zakharenkova Irina , Cherniak Iurii 
Published: February 2020

AbstractWe present a new pattern of storm‐induced ionospheric irregularities behavior at midlatitudes—poleward‐streaming plasma density depletions. Under disturbed conditions, they appear at North America low latitudes as a part of extended postsunset equatorial plasma bubbles, and further, they are streaming from low latitudes in a northwestward, poleward direction toward the main ionospheric trough and auroral irregularities zone. The poleward‐streaming plasma depletions represent a new phenomenon with the similar northwestward transportation path across the continental United States as storm‐enhanced density (SED) plumes. The channels of poleward‐streaming plasma depletions were stretched from low‐latitude base toward higher latitudes—they are found to occur for geomagnetic storms under specific combination of steady southward interplanetary magnetic field, subauroral polarization streams (SAPS) electric fields, and enhanced westward drifts at midlatitudes, resulting in northwestward plasma transportation equatorward of the SAPS region. The poleward‐streaming plasma depletions form an illusion of traveling ionospheric disturbances (TIDs) moving in a poleward, northwestward direction—this propagation direction is opposite to typical equatorward propagation of storm‐induced large‐scale TIDs generated in the auroral zone and propagated toward the equator. This phenomenon is accompanied by strong ionospheric irregularities that occurred over both edges of plasma depletion channel at midlatitudes. For two comparable geomagnetic storms, these poleward‐streaming plasma depletions persisted for several hours, posing a localized threat for GPS‐based positioning applications. Even moderate‐to‐intense storms (Dst minimum−145 nT) can promote such effects at midlatitudes.
Rupture Process of the 26 May 2019 Mw 8.0 Northern Peru Intermediate‐Depth Earthquake and Insights Into Its Mechanism
Authors: Liu Wei , Yao Huajian 
Published: February 2020

AbstractIn the Nazca‐South American subduction zone, the subducted slab is flattened beneath northern Andes, called the Peruvian flat slab. The 2019 Mw 8.0 northern Peru intermediate‐depth normal‐faulting earthquake occurred at the leading edge of the Peruvian flat slab, where the slab rebends and sinks into greater depths. Here we investigate this earthquake by back projection analysis and finite fault inversion using seismic waveforms at teleseismic distances. The rupture process indicates that this earthquake ruptured mainly along strike (353°) ~150 km north‐northwestward within ~55 s (average rupture velocity ~2.7 km/s), resulting in two major slip areas with three high slip rate areas, which are consistent with three high‐frequency energy radiation subevents. Our study suggests that such a heterogeneous rupture may be caused by slab bending forces and dehydration embrittlement associated with morphology of the slab.
Daratumumab monotherapy for patients with intermediate-risk or high-risk smoldering multiple myeloma: a randomized, open-label, multicenter, phase 2 study (CENTAURUS)
Authors: Landgren C. Ola , Chari Ajai , Cohen Yael C. , Spencer Andrew , Voorhees Peter , Estell Jane A. , Sandhu Irwindeep , Jenner Matthew W. , Williams Catherine , Cavo Michele , van de Donk Niels W. C. J. , Beksac Meral , Moreau Philippe , Goldschmidt Hartmut , Kuppens Steven , Bandekar Rajesh , Clemens Pamela L. , Neff Tobias , Heuck Christoph , Qi Ming , Hofmeister Craig C. 
Published: February 2020

AbstractCurrent guidelines for smoldering multiple myeloma (SMM) recommend active monitoring until the onset of multiple myeloma (MM) before initiating treatment or enrollment in a clinical trial. Earlier intervention may delay progression to MM. In CENTAURUS, 123 patients with intermediate-risk or high-risk SMM were randomly assigned to daratumumab 16 mg/kg intravenously on extended intense (intense), extended intermediate (intermediate), or short dosing schedules. At the prespecified primary analysis (15.8-month median follow-up), the complete response (CR) rates (co-primary endpoint) were 2.4%, 4.9%, and 0% for intense, intermediate, and short dosing, respectively; the co-primary endpoint of CR rate >15% was not met. Progressive disease (PD)/death rates (number of patients who progressed or died divided by total duration of progression-free survival [PFS] in patient-years; co-primary endpoint) for intense, intermediate, and short dosing were 0.055 (80% confidence interval [CI], 0.014–0.096), 0.102 (80% CI, 0.044–0.160), and 0.206 (80% CI, 0.118–0.295), respectively, translating to a median PFS ≥24 months in all arms (P < 0.0001, <0.0001, and =0.0213, respectively). With longer follow-up (median follow-up, 25.9 months), CR rates were 4.9%, 9.8%, and 0% for intense, intermediate, and short dosing, respectively. PD/death rates for intense, intermediate, and short dosing were 0.059 (80% CI, 0.025–0.092), 0.107 (80% CI, 0.058–0.155), and 0.150 (80% CI, 0.089–0.211), respectively, again translating to a median PFS ≥ 24 months in all arms (P < 0.0001 for all arms). Twenty-four–month PFS rates were 89.9% (90% CI, 78.5–95.4%), 82.0% (90% CI, 69.0–89.9%), and 75.3% (90% CI, 61.1–85.0%) for intense, intermediate, and short dosing, respectively. Pharmacokinetic analyses indicated that intense dosing maintained target-saturating trough concentrations in most patients throughout weekly, every-2-week, and every-4-week dosing periods. No new safety signals were observed. These data provide the basis for an ongoing phase 3 study of daratumumab in SMM.
mPTP opening caused by Cdk5 loss is due to increased mitochondrial Ca2+ uptake
Authors: NavaneethaKrishnan Saranya , Rosales Jesusa L. , Lee Ki-Young 
Published: February 2020

AbstractWe previously demonstrated that loss of Cdk5 in breast cancer cells promotes ROS-mediated cell death by inducing mitochondrial permeability transition pore (mPTP) opening (Oncogene 37, 1788–1804). However, the molecular mechanism by which Cdk5 loss causes mPTP opening remains to be investigated. Using primary mouse embryonic fibroblasts (MEFs) isolated from Cdk5−/− mouse embryos, we show that absence of Cdk5 causes a significant increase in both mPTP opening and mitochondrial Ca2+ level. Analysis of subcellular fractions of MEFs demonstrates that Cdk5 localizes in the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) and Cdk5 loss in MAMs causes increased ER-mitochondria tethering, a process required for Ca2+ transfer from the ER to the mitochondria. Loss of Cdk5 also causes increased ATP-mediated mitochondrial Ca2+ uptake from the ER. Inhibition of ER Ca2+ release or mitochondrial Ca2+ uptake in Cdk5−/− MEFs prevents mPTP opening, indicating that mPTP opening in Cdk5−/− MEFs is due to increased Ca2+ transfer from the ER to the mitochondria. Altogether, our findings suggest that Cdk5 in MAMs regulates mitochondrial Ca2+ homeostasis that is disturbed upon Cdk5 loss, which leads to mPTP opening.
Lipidome-based rapid diagnosis with machine learning for detection of TGF-β signalling activated area in head and neck cancer
Authors: Ishii Hiroki , Saitoh Masao , Sakamoto Kaname , Sakamoto Kei , Saigusa Daisuke , Kasai Hirotake , Ashizawa Kei , Miyazawa Keiji , Takeda Sen , Masuyama Keisuke , Yoshimura Kentaro 
Published: February 2020

Abstract
Background
Several pro-oncogenic signals, including transforming growth factor beta (TGF-β) signalling from tumour microenvironment, generate intratumoural phenotypic heterogeneity and result in tumour progression and treatment failure. However, the precise diagnosis for tumour areas containing subclones with cytokine-induced malignant properties remains clinically challenging.

Methods
We established a rapid diagnostic system based on the combination of probe electrospray ionisation-mass spectrometry (PESI-MS) and machine learning without the aid of immunohistological and biochemical procedures to identify tumour areas with heterogeneous TGF-β signalling status in head and neck squamous cell carcinoma (HNSCC). A total of 240 and 90 mass spectra were obtained from TGF-β-unstimulated and -stimulated HNSCC cells, respectively, by PESI-MS and were used for the construction of a diagnostic system based on lipidome.

Results
This discriminant algorithm achieved 98.79% accuracy in discrimination of TGF-β1-stimulated cells from untreated cells. In clinical human HNSCC tissues, this approach achieved determination of tumour areas with activated TGF-β signalling as efficiently as a conventional histopathological assessment using phosphorylated-SMAD2 staining. Furthermore, several altered peaks on mass spectra were identified as phosphatidylcholine species in TGF-β-stimulated HNSCC cells.

Conclusions
This diagnostic system combined with PESI-MS and machine learning encourages us to clinically diagnose intratumoural phenotypic heterogeneity induced by TGF-β.
Long non-coding RNA dysregulation is a frequent event in non-small cell lung carcinoma pathogenesis
Authors: Acha-Sagredo Amelia , Uko Bubaraye , Pantazi Paschalia , Bediaga Naiara G. , Moschandrea Chryssanthi , Rainbow Lucille , Marcus Michael W. , Davies Michael P. A. , Field John K. , Liloglou Triantafillos 
Published: February 2020

Abstract
Background
Long non-coding RNAs compose an important level of epigenetic regulation in normal physiology and disease. Despite the plethora of publications of lncRNAs in human cancer, the landscape is still unclear.

Methods
Microarray analysis in 44 NSCLC paired specimens was followed by qPCR-based validation in 29 (technical) and 38 (independent) tissue pairs. Cross-validation of the selected targets was achieved in 850 NSCLC tumours from TCGA datasets.

Results
Twelve targets were successfully validated by qPCR (upregulated: FEZF1-AS1, LINC01214, LINC00673, PCAT6, NUTM2A-AS1, LINC01929; downregulated: PCAT19, FENDRR, SVIL-AS1, LANCL1-AS1, ADAMTS9-AS2 and LINC00968). All of them were successfully cross validated in the TCGA datasets. Abnormal DNA methylation was observed in the promoters of FENDRR, FEZF1-AS1 and SVIL-AS1. FEZF1-AS1 and LINC01929 were associated with survival in the TCGA set.

Conclusions
Our study provides through multiple levels of internal and external validation, a comprehensive list of dysregulated lncRNAs in NSCLC. We therefore envisage this dataset to serve as an important source for the lung cancer research community assisting future investigations on the involvement of lncRNAs in the pathogenesis of the disease and providing novel biomarkers for diagnosis, prognosis and therapeutic stratification.
Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing
Authors: Sorkin Michael , Huber Amanda K. , Hwang Charles , Carson William F. , Menon Rajasree , Li John , Vasquez Kaetlin , Pagani Chase , Patel Nicole , Li Shuli , Visser Noelle D. , Niknafs Yashar , Loder Shawn , Scola Melissa , Nycz Dylan , Gallagher Katherine , McCauley Laurie K. , Xu Jiajia , James Aaron W. , Agarwal Shailesh , Kunkel Stephen , Mishina Yuji , Levi Benjamin 
Published: February 2020

AbstractHeterotopic ossification (HO) is an aberrant regenerative process with ectopic bone induction in response to musculoskeletal trauma, in which mesenchymal stem cells (MSC) differentiate into osteochondrogenic cells instead of myocytes or tenocytes. Despite frequent cases of hospitalized musculoskeletal trauma, the inflammatory responses and cell population dynamics that regulate subsequent wound healing and tissue regeneration are still unclear. Here we examine, using a mouse model of trauma-induced HO, the local microenvironment of the initial post-injury inflammatory response. Single cell transcriptome analyses identify distinct monocyte/macrophage populations at the injury site, with their dynamic changes over time elucidated using trajectory analyses. Mechanistically, transforming growth factor beta-1 (TGFβ1)-producing monocytes/macrophages are associated with HO and aberrant chondrogenic progenitor cell differentiation, while CD47-activating peptides that reduce systemic macrophage TGFβ levels and help ameliorate HO. Our data thus implicate CD47 activation as a therapeutic approach for modulating monocyte/macrophage phenotypes, MSC differentiation and HO formation during wound healing.
Neo-functionalization of a Teosinte branched 1 homologue mediates adaptations of upland rice
Authors: Lyu Jun , Huang Liyu , Zhang Shilai , Zhang Yesheng , He Weiming , Zeng Peng , Zeng Yan , Huang Guangfu , Zhang Jing , Ning Min , Bao Yachong , Zhao Shilei , Fu Qi , Wade Len J. , Chen Hua , Wang Wen , Hu Fengyi 
Published: February 2020

AbstractThe rice orthologue of maize domestication geneTeosinte branched 1(Tb1) affects tillering. But, unlike maizeTb1gene, it was not selected during domestication. Here, we report that anOsTb1duplicate gene (OsTb2) has been artificially selected during upland rice adaptation and that natural variation inOsTb2is associated with tiller number. Interestingly, transgenic rice overexpressing this gene shows increased rather than decreased tillering, suggesting thatOsTb2gains a regulatory effect opposite to that ofOsTb1following duplication. Functional analyses suggest that the OsTb2 protein positively regulates tillering by interacting with the homologous OsTb1 protein and counteracts the inhibitory effect of OsTb1 on tillering. We further characterize two functional variations withinOsTb2that regulate protein function and gene expression, respectively. These results not only present an example of neo-functionalization that generates an opposite function following duplication but also suggest that theTb1homologue has been selected in upland rice.
Polarized resonant emission of monolayer WS2 coupled with plasmonic sawtooth nanoslit array
Authors: Han Chunrui , Ye Jianting 
Published: February 2020

AbstractTransition metal dichalcogenide (TMDC) monolayers have enabled important applications in light emitting devices and integrated nanophotonics because of the direct bandgap, spin-valley locking and highly tunable excitonic properties. Nevertheless, the photoluminescence polarization is almost random at room temperature due to the valley decoherence. Here, we show the room temperature control of the polarization states of the excitonic emission by integrating WS2 monolayers with a delicately designed metasurface, i.e. a silver sawtooth nanoslit array. The random polarization is transformed to linear when WS2 excitons couple with the anisotropic resonant transmission modes that arise from the surface plasmon resonance in the metallic nanostructure. The coupling is found to enhance the valley coherence that contributes to ~30% of the total linear dichroism. Further modulating the transmission modes by optimizing metasurfaces, the total linear dichroism of the plasmon-exciton hybrid system can approach 80%, which prompts the development of photonic devices based on TMDCs.
Novel mucosal adjuvant, mastoparan-7, improves cocaine vaccine efficacy
Authors: St. John Ashley L. , Choi Hae Woong , Walker Q. David , Blough Bruce , Kuhn Cynthia M. , Abraham Soman N. , Staats Herman F. 
Published: February 2020

AbstractCocaine is one of the most potent and addictive psychostimulants known and there are no available pharmacotherapies to treat cocaine addiction. Here we describe a novel cocaine vaccine employing the mucosal adjuvant and mast cell-activating oligopeptide, mastoparan-7 (M7), to achieve optimal IgA antibody responses in mucosal secretions and effective induction of humoral immunity using a short immunization protocol. This formulation, using a hapten-carrier system to deliver cocaine as antigen, also reduced cocaine penetration of the blood brain barrier and protected mice from its psychoactive effects by reducing cocaine-induced locomotion. Surprisingly, the magnitude of cocaine-specific antibody titers induced by each adjuvant was not the major determinant of functional protection from cocaine challenge. A side-by-side comparison of the two haptens, cocaine and its analog GNC demonstrated that cocaine haptenation resulted in superior functional protection when used in combination with the novel mucosal adjuvant, M7. These results provide a new potential strategy for combatting cocaine addiction through mucosal vaccination.
Influence of Severity of Type and Timing of Retrospectively Reported Childhood Maltreatment on Female Amygdala and Hippocampal Volume
Authors: Herzog Julia I. , Thome Janine , Demirakca Traute , Koppe Georgia , Ende Gabriele , Lis Stefanie , Rausch Sophie , Priebe Kathlen , Müller-Engelmann Meike , Steil Regina , Bohus Martin , Schmahl Christian 
Published: February 2020

AbstractDeleterious effects of adverse childhood experiences (ACE) on human brain volume are widely reported. First evidence points to differential effects of ACE on brain volume in terms of timing of ACE. Upcoming studies additionally point towards the impact of different types (i.e., neglect and abuse) of ACE in terms of timing. The current study aimed to investigate the correlation between retrospectively reported severity of type (i.e., the extent to which subjects were exposed to abuse and/or neglect, respectively) and timing of ACE on female brain volume in a sample of prolonged traumatized subjects. A female sample with ACE (N = 68) underwent structural magnetic resonance imaging and a structured interview exploring the severity of ACE from age 3 up to 17 using the “Maltreatment and Abuse Chronology of Exposure” (MACE). Random forest regression with conditional interference trees was applied to assess the impact of ACE severity as well as the severity of ACE type, (i.e. to what extent individuals were exposed to neglect and/or abuse) at certain ages on pre-defined regions of interest such as the amygdala, hippocampus, and anterior cingulate (ACC) volume. Analyses revealed differential type and timing-specific effects of ACE on stress sensitive brain structures: Amygdala and hippocampal volume were affected by ACE severity during a period covering preadolescence and early adolescence. Crucially, this effect was driven by the severity of neglect.
The gender dependent influence of sodium bicarbonate supplementation on anaerobic power and specific performance in female and male wrestlers
Authors: Durkalec–Michalski Krzysztof , Zawieja Emilia E. , Zawieja Bogna E. , Michałowska Patrycja , Podgórski Tomasz 
Published: February 2020

AbstractThe aim of this study was the assessment of progressive low-dose sodium bicarbonate (NaHCO3) supplementation on the anaerobic indices in two bouts of Wingate tests (WT) separated by wrestling-specific performance test and assessing the gender differences in response. Fifty-one (18 F) wrestlers completed a randomized trial of either a NaHCO3 (up to 100 mg·kg−1) or a placebo for 10 days. Before and after treatment, athletes completed an exercise protocol that comprised, in sequence, the first WT1, dummy throw test (DT), and second WT2. The number of completed throws increased significantly in males from 19.3 ± 2.6 NaHCO3pre to 21.7 ± 2.9 NaHCO3post. ΔWT2-WT1 improved particularly in the midsection of 30-s WT on NaHCO3. However, no significant differences were found in peak power (PP), power drop (PD) and average power (AP) (analyzed separately for each WT), and ΔWT2-WT1 in PP and PD. Interaction with gender was significant for AP, PP and PD, every second of WT1 and WT2, as well as DT test. In conclusion, our study suggests that the response to NaHCO3 may be gender-specific and progressive low-dose NaHCO3 supplementation allows the advantageous strengthening of wrestling-specific performance in males. It can also lead to maintenance of high anaerobic power mainly in the midsection of the 30-s Wingate test.
Graphlets in Multiplex Networks
Authors: Dimitrova Tamarа , Petrovski Kristijan , Kocarev Ljupcho 
Published: February 2020

AbstractWe develop graphlet analysis for multiplex networks and discuss how this analysis can be extended to multilayer and multilevel networks as well as to graphs with node and/or link categorical attributes. The analysis has been adapted for two typical examples of multiplexes: economic trade data represented as a 957-plex network and 75 social networks each represented as a 12-plex network. We show that wedges (open triads) occur more often in economic trade networks than in social networks, indicating the tendency of a country to produce/trade of a product in local structure of triads which are not closed. Moreover, our analysis provides evidence that the countries with small diversity tend to form correlated triangles. Wedges also appear in the social networks, however the dominant graphlets in social networks are triangles (closed triads). If a multiplex structure indicates a strong tie, the graphlet analysis provides another evidence for the concepts of strong/weak ties and structural holes. In contrast to Granovetter’s seminal work on the strength of weak ties, in which it has been documented that the wedges with only strong ties are absent, here we show that for the analyzed 75 social networks, the wedges with only strong ties are not only present but also significantly correlated.
GloBody Technology: Detecting Anti-Drug Antibody against VH/VL domains
Authors: Saxena Gauri K. , Theocharopoulos Ioannis , Aziz Nisha Thaslima , Jones Meleri , Gnanapavan Sharmilee , Giovannoni Gavin , Schmierer Klaus , Garnett James A. , Baker David , Kang Angray S. 
Published: February 2020

AbstractThe occurrence of anti-drug antibodies following administration of therapeutic monoclonal antibody to patients is a growing problem that is attracting attention from frontline clinicians. Ideally, an initial indicative point of care test would provide guidance to seek testing approved by the regulatory authorities. Here we describe a platform for the detection of IgG anti-drug antibodies that may provide an initial screen for all therapeutic monoclonal antibodies. Synthetic genes encoding Nanoluciferase polypeptides were inserted between the variable heavy and light domain encoding region of known antibody drugs (alemtuzumab and adalimumab) to generate recombinant single chain GloBodies, which retain the drug antibody paratopes and Nanoluciferase activity. In the presence of anti-drug antibodies, the GloBody is bound by specific IgG in the sample. These complexes are captured on immobilised Protein G and the luciferase activity determined. The amount of light generated being indicative of the anti-drug IgG antibody levels in serum. It should be possible to assemble GloBody reagents for all therapeutic monoclonal antibodies and adapt the capture phase to include additional specific isotypes. The assay has the potential to be developed for use with a drop of blood allowing initial pre-screening in a point of care setting.