bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying public stakeholders effective on mental health promotion in Iran
Authors: Damari Behzad , Esmaili Mohammad Reza Amir , Rafiee Noora , Hajebi Ahmad 
Published: May 2020

Abstract
Background: It is not always easy to put mental health on the agenda of sectors other than the health sector. However, it is now confirmed that mental health promotion policies need innovations beyond the scope of the health sector to be efficient. Thus, in this study, an attempt was made to identify the most effective stakeholders of the public sector in the field of mental health promotion in Iran to help the policy-makers of said sector and to encourage the inter-sectoral cooperation and further involvement of these effective sectors in mental health promotion plans. Methods: This was a mixed-methods study. From the data of the first step (literature review and a survey involving professors of relevant disciplines), the names of government agencies related to the domain of mental health were extracted. In the second step, a checklist was developed, the horizontal axis of which was the relevant organizations and the vertical axis was the social risk factors effective on mental health promotion. The data of this step were analyzed by the simple additive weighting method. In the final step, a table was plotted in the form of institutional mapping in order to summarize the organizations affecting each risk factor. Results: The Islamic Consultative Assembly, the Ministry of Interior, the Islamic Republic of Iran Broadcasting, the Ministry of Cooperatives, Labor, and Social Welfare, and the Ministry of Education were identified as five organizations with the greatest impacts on the social determinants of mental health promotion in Iran. Conclusions: Significant impacts can be exerted by institutions such as the Islamic Consultative Assembly (as the legislator), the Ministry of Interior and its subsidiary entities such as municipalities and governors (as the administrators of homeland security and support for safe and appropriate urban and local facilities), the Islamic Republic of Iran Broadcasting (as the national media), the Ministry of Cooperatives, Labor, and Social Welfare (as the institution in charge of employment, job security, and social welfare), and the Ministry of Education (as the educational institution of the country).
Relationships between menstrual status and obesity phenotypes in women: a cross-sectional study in northern China
Authors: Chen Xueyu , Liu Huamin , Liu Weihua , Chen Yanru , Wang Xiaohui , Zhang Wenran , Shi Fengxue , Sui Xinxia , Wang Xiaojun , Zhang Haitao , Ji Long , Xi Hui , Li Dong 
Published: May 2020

Abstract
Background: One of most important concerns of postmenopausal women is obesity. The relationships between menstruation status and obesity phenotypes are unclear. This study aimed to assess the associations between menstrual status and different obesity phenotypes in women.Methods: In total, 5373 women aged ≥40 years were recruited from the Jidong and Kailuan communities. Basic information was collected via clinical examination, laboratory testing and standardized questionnaires. The women were stratified into the following three groups: menstrual period, menopausal transition period and postmenopausal period. General obesity was defined as a body mass index (BMI) of ≥28 kg/m2. Central obesity was defined as a waist-to-hip ratio (WHR) of >0.85. Visceral obesity was defined as the presence of nonalcoholic fatty liver disease (NAFLD) and increased pericardial fat volume (PFV). Results: The numbers of women in the menstrual, menopausal transition, and postmenopausal periods were 2807 (52.2%), 675 (12.6%) and 1891 (35.2%), respectively. The adjusted odds ratio (OR) and 95% confidence interval (CI) for central obesity among women in the menopausal transition and postmenopausal periods compared with women in the menstrual period were 1.34 (0.87-2.05) and 0.87 (0.57-1.33), respectively. The OR for NAFLD among postmenopausal women was 1.78 (1.44-2.20). The adjusted β-coefficient (standard error, SE) for PFV among postmenopausal women was 41.25 (7.49). The adjusted OR for general obesity among postmenopausal women was 1.01 (0.77-1.34). Conclusions: This study demonstrated that menopause is an independent risk factor for central and visceral obesity but not general obesity.
Treatment of supraventricular tachycardias in patients with non-cardiac surgery by dexmedetomidine during the perioperative period
Authors: Xu Yan , Hu CuiWen , Guo Xuan , Hu ZhiHong , Shi Hui , zhang JunLong 
Published: May 2020

Abstract
Background: Supraventricular tachycardias (SVTs) can increase the risk of adverse events in perioperative period. Previous studies have shown that application of dexmedetomidine (DEXm) combined anesthesia during surgery can significantly reduce postoperative cardiovascular and cerebrovascular complications and mortality in patients with cardiac disease. In fact, many anesthetic drugs have cardiac protection effects. However, it is a pity that these findings are not well applied in clinical practice to treat cardiac disease. Therefore, the aim of this study was to explore the therapeutic effect of DEXm on perioperative SVTs in adult patients with non-cardiac surgery. Methods: Forty-two patients with SVTs, aged between 35 and 61 years, were randomly divided into DEXm group (group D) and midazolam group (group M). The patients undergoing elective surgery in two groups were infused intravenously DEXm 0.5-1µg/kg or midazolam 0.06-0.08mg/kg using a micro-pump for 10 minutes, respectively. The the Observer’s Assessment of Alertness/Sedation (OAA/S) score, heart rate (HR), mean arterial pressure (MAP), pulse oxygen saturation (SpO2) and occurrence of SVTs, heart rate variability (HRV) including normalized low frequency power (LFnorm), normalized high frequency power (HFnorm) and the balance ratio of sympathetic to vagal tone (LF/HF) in two groups were recorded at T0 (before the infusion DEXm or midazolam), T1 (5 minutes after the infusion), T2 (at the end of the infusion), T3 (5 minutes after the end of the infusion), and T4 (10 minutes after the end of the infusion). Results: The OAA/S score in two groups at T4 was obviously decreased compared with T0. And the OAA/S score in group M was lower than in group D at T4 (P<0.05). Compared to T0, HR and MAP in two groups were obviously decreased, and HR and MAP in group D were apparently lower than group M from T1 to T4 (P<0.05). Three patients developed mild hypotension in group D. However, none of patients developed clinically significant bradycardia, hypotension, and anoxia. There was no significant difference for SpO2 from T0 to T4 in group D. Compared to T0 or group D, SpO2 in group M obviously decreased at T2 (P<0.05). In addition, SVTs in all patients were terminated until T4 in group D after DEXm infusion. However, only two patients were finally improved in group M. Compared to T0, HFnorm were elevated, and LFnorm and LF/HF were decreased from T1 to T4, furthermore, the changes in HFnorm, LFnorm and LF/HF had statistical significance (P<0.05) in group D. However, there was no significant difference for HFnorm, LFnorm and LF/HF in group M from T0 to T4.Conclusions: Perioperative use of dexmedetomidine had a significant therapeutic effect for supraventricular tachycardias without significant adverse effects in adult patients .Trial Registration: ClinicalTrials.gov Registration Number: NCT04284150 on 26th February 2020
Determinants of quality of life and life satisfaction of urban residents
Authors: Kotarski Hubert 
Published: May 2020

Abstract
The aim of the study was to investigate the quality of life of Rzeszow residents aged 18-75 using a WHOQOL-BREF questionnaire which consists of 26 questions and analyses 4 basic domains of quality of life: physical, psychological, social relationships, functional environment of the respondent and a global quality of life and self-assessment of one’s health. The survey was conducted on a representative sample of 618 adult residents of Rzeszow. Respondents were randomly selected through systematic random sampling with latent layer division from the population register shared by Rzeszow Municipal Office. The analysis of factors differentiating the residents’ assessment of quality of life was based on socio-demographic variables such as gender, age and education and variables representing social factors - financial situation and body mass index (BMI). The results indicate that gender does not differentiate the quality of life of Rzeszow residents. However, the quality of life is affected by age, education, financial situation, and body mass index.
Identification of acute myeloid leukemia-driven genes by multi-dimensional approach
Authors: Jian Jimo , Hao Hongyuan , Liu Qian , Dong Wenhao , Li Lu , Liu Yalu , Feng Gege , Wang Juan , Gao Sheng , Chen Lai , Lu Fei , Yuan Chenglu 
Published: May 2020

Abstract
Background

Acute myeloid leukemia (AML), which is characterized by the uncontrolled proliferation of myeloid leukemia cells in the bone marrow and other hematopoietic tissues, and is highly heterogeneous. While with the progress of sequencing technology, understanding of the AML-related biomarkers are still incomplete. The purpose of this study is to identify potential biomarkers for diagnosis of AML.

Methods

Based on WGCNA analysis of gene mutation expression, methylation level distribution, mRNA expression and AML-related genes in public databases, were employed for investigating potential biomarkers for prognosis of AML.

Results

This study screened a total of 6,383 genes by analyzing various changes in 103 acute myeloid leukemia (AML) samples, including gene mutation expression, methylation level distribution, mRNA expression, and AML-related genes in public databases. Moreover, seven AML-related co-expression modules were mined by WGCNA analysis and twelve biomarkers associated with the AML prognosis were identified from each top 10 genes of the seven co-expression modules. The AML samples were then classified into two subgroups, the prognosis of which is significantly different, based on the expression of these twelve genes. The differentially expr essed genes are mainly involved in glucose metabolism, glutathione biosynthesis, small G protein-mediated signal transduction, and the Rap1 signaling pathway.

Conclusions

With the utilization of WGCNA mining, seven gene co-expression modules were identified from TCGA database and there are unreported genes that may as potential driven genes of AML and may be the direction to identify the possible molecular signatures to predict survival of AML patients and help guide experiments for potential clinical drag targets.
A machine learning model for the prediction of drug permeability across the Blood-Brain Barrier: a comparative approach
Authors: Saber Ralph , Mhanna Rami , Rihana Sandy 
Published: May 2020

Abstract
Background: Drug permeability across the blood-brain barrier (BBB) is a critical challenge for successful drug discovery which has led to multiple efforts to develop in silico predictive models. Most of the in silico models are based on the molecular descriptors of the drugs. In this work, we compare the ability of sequential feature selection and genetic algorithms in selecting the most relevant descriptors and hence enhancing the permeability prediction accuracy.Methods: Five different classifiers were initially trained on a dataset using eight molecular descriptors. Then, sequential feature selection and genetic algorithms were performed separately and the same classifiers were trained using the descriptors chosen by each algorithm.Results: The highest overall accuracy obtained without feature selection was 94.98%. This accuracy increased with sequential feature selection and genetic algorithms on multiple classifiers. However, the highest accuracy (96.23%) was obtained after performing genetic algorithm on the feature vector. Moreover, genetic algorithm with a fitness function based on the performance of a support vector machine led to an increase in the accuracy of all the tested classifiers unlike sequential feature selection.Conclusions: The findings show that genetic algorithm is a more robust approach than sequential feature selection in choosing the most relevant molecular descriptors involved in the permeability across the blood-brain barrier. The results also highlight the importance of the polar surface area of drugs in crossing the BBB.
Optimal risk classification with statistical evidence in endometrial cancer
Authors: Chang Chung , Chiang An Jen , Chiu Yi Chieh , Hsu Li-Chuan , Hsu Pei-Hua , Kan Yuen-Yee , Chen Jiabin 
Published: May 2020

Abstract
Background

It is often clinically useful to classify tumor markers into risk groups. This study was aimed to investigate whether beginning with a statistically sound method would find cut points more reasonable than conventional ones.
Methods

We used data of endometrial cancer including 442 patients. The optimal number of cutoffs was based on the Akaike criterion and statistical algorithms were adapted to find the best locations. Codes were provided as a package.
Results

Myometrium invasion was an independent risk factor for lymph nodal metastasis when stratified into three groups by 0.41 and 0.89. Tumor size was an independent risk factor for overall survival when stratified into two groups by 4.11 cm. Both had better prediction than conventional choices and clinical relevance.
Conclusion

A statistically sound algorithm should be used to stratify patients into risk groups.
Pretreatment C-reactive protein and neutrophil counts as a predictor of metastasis in patients with osteosarcoma
Authors: Araki Yoshihiro , Yamamoto Norio , Hayashi Katsuhiro , Takeuchi Akihiko , Miwa Shinji , Igarashi Kentaro , Higuchi Takashi , Abe Kensaku , Taniguchi Yuta , Yonezawa Hirotaka , Morinaga Sei , Asano Yohei , Tsuchiya Hiroyuki 
Published: May 2020

Abstract
Background: Systemic inflammation responses have been associated with cancer development, progression and metastasis. However, little is known about the risk of metastasis based on inflammatory-based scores in patients with osteosarcoma before treatment. We therefore estimated the predictive value of these parameters for metastasis in osteosarcoma.Methods: A total of 54 osteosarcoma patients were enrolled in this retrospective study. All had been diagnosed histologically, and their laboratory data at the first visit were collected from medical records. The lymphocyte-monocyte ratio (LMR), neutrophil-lymphocyte ratio (NLR), monocyte-neutrophil ratio (MNR), platelet-lymphocyte ratio (PLR), Glasgow prognostic score (GPS), neutrophil-platelet score (NPS), neutrophil counts (NC), lymphocyte counts (LC), monocyte counts (MC), and C-reactive protein (CRP) were evaluated.Results: High values of CRP, PLR, MNR, and NPS and a low NC were significantly associated with metastasis of osteosarcoma patients in the univariate analysis. A multivariate Cox regression analysis revealed that a high CRP level (>0.6mg/dL) (hazard ratio=9.7, 95% confidence interval=3.0-31 ; p=0.00010) and low NC (<4087/µL) (hazard ratio=0.13, 95% confidence interval =0.040-0.42 ; p=0.00080) were risk factors significantly associated with metastasis of osteosarcoma patients.Conclusions: Our study demonstrated that the combination of a high CRP level and low NC before treatment was a useful inflammatory-based prognostic indicator for metastasis in patients with osteosarcoma.
Flexion Dysfunction of Atlanto-occipital Joint as a Risk Factor for Cervical Spondylosis
Authors: Long Gong , Ping Yi , Mingsheng Tan 
Published: May 2020

Abstract
BACKGROUND: There exist varied craniocervical flexion angles from the teenagers to the elderly. To our best knowledge, there is no prior study to examine the role of range of motion (ROM) of the atlanto-occipital joint in the pathogenesis of cervical spondylosis (CS). The purpose of this study was to investigate the association between atlanto-occipital radiographic alignment in flexion and CS.METHODS: 232 CS patients, including 45 patients who accepted surgical treatment, were retrospectively reviewed. The angle between McGregor’s line and C1 line (O-C1 angle) was evaluated on images taken in flexion (F-OC) and neutral positions (N-OC) independently. The relationship between the FOC (FOC=F-OC—N-OC) and Neck Disability Index (NDI) was examined, and the involvement of the FOC in the onset of CS was analyzed. Receiver operating characteristic (ROC) curve analysis was performed to determine the optimal cut-off for detecting an increased risk of CS.RESULTS: The FOC showed a significant correlation with NDI(P<0.05). The mean FOC was significantly lower in the CS groups than in the control group (P<0.001). Logistic regression analysis showed involvement of the FOC in the onset of CS, and the threshold value according to receiver operating characteristic curve analysis was 4.2 degree, with the odds ratio of 8.2 (95% CI:6.4–10.0; P<0.001). CONCLUSION: Stiff atlanto-occipital joint, represented by low FOC, is an independent risk factor in the incidence of CS compared with healthy individuals. This parameter can help spine surgeons to identify these people to implement appropriate preventive and management steps.
Determinants of treatment outcomes of severe acute malnutrition among under-5 children in Yekatit 12 Hospital, Addis Ababa, Ethiopia: a retrospective cohort study
Authors: Kebede Mekonen Adimasu , Teshome Girum Sebsbie , Fenta Fkirtemariam Abebe , Getahun Melaku Bimerew 
Published: May 2020

Abstract
Background

Devastatingly, the number of children with SAM is still growing globally. Severe acute malnutrition is the third most common contributing factor to the deaths of under-5 children worldwide. According to the World Health Organization, severe acute malnutrition causes 1 million deaths annually via increased susceptibility to death from severe infection. Ethiopia is one of the countries with highest under-5 child mortality rate, with malnutrition underlying to 28% of all children deaths. In Ethiopia, some studies reported an alarming death and default rates which indicate the need for further study to assess contributing factors to the treatment outcomes of severe acute malnutrition. Therefore, the intention of this research is to determine the treatment outcomes of severe acute malnutrition and identify predictors of nutritional recovery.
Method:

A retrospective cohort study was conducted among 423 under-5 children with severe acute malnutrition. Logistic regression analysis was performed and an adjusted odd ratio with 95%CI was used to determine independent predictors.
Result

The overall recovery, death and default rates were 81.3%, 11.1% and 7.6% respectively. Age, vaccination status, HIV/AIDS, pneumonia, diarrhea and stunting were found to be significant independent predictors of treatment outcomes. The adjusted odd ratio (AOR) for nutritional recovery increased by 14.6% for every 1-month increase in child age (AOR = 1.146; 95%CI: 1.052–1.249). Regarding vaccination status, those under-5 children who were fully vaccinated for their age were about 4 time more likely to recover than their counterparts (AOR = 4.242; 95%CI: 1.566–11.491)
Conclusion

In conclusion, the overall nutritional recovery and default rate in this study were in the acceptable range of international standard even though the death rate was higher. Age and full vaccination were proven to increase nutritional recovery. Conversely, the presence of HIV/AIDS, pneumonia, diarrhea and stunting were proven to decrease nutritional recovery.
Study of The Influence of Chromium on A Cobalt Iron Alloy
Authors: mebrek smain , zergoug mourad , haine nacereddine 
Published: May 2020

Abstract
The present work comes within the framework of research of new materials, with improved properties, which could be an important key for innovative applications. For this purpose, two types of alloys, a binary (Fe, Co) and a ternary (Fe, Co, Cr), were first synthesized by mechanical grinding at high energy, varying the grinding time. In a second step, all the samples were subjected to various characterizations, a structural study (X-ray diffraction), a morphological study (scanning electron microscopy "SEM"), a magnetic characterization (the "VSM" vibrating sample magnetometer And finally, an electrical study (eddy currents). Numerous and valuable information was then deduced to know the variations in the average lens size, the internal micro deformation, the cell parameter, the saturation magnetization, the remnant field, the coercive field as well as the Z impedance, according to a only parameter, the grinding time.
The region ahead of the pancreas is a suitable place for performing endoscopic ultrasound-guided gastroenterostomy: from clinical data to swine trial
Authors: Hu Jinlong , Wang Guoxin , Gao Haixin , Sheng Shiyun , Sun Siyu 
Published: May 2020

Abstract
Background and Aims: Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) is a minimally invasive treatment for gastric outlet obstruction that results in a low incidence of recurrence. This is the first study to investigate a suitable position for performing EUS-GE. Methods: We reviewed the clinical data from 20 upper gastrointestinal examinations and 20 computed tomography scans of the abdomen and hypothesized that the posterior wall of the stomach was a suitable place to perform EUS-GE. We verified this hypothesis by performing an animal study using 5 swine. Results: All retrievable anchor assisted EUS-GE were successfully performed at the intestinal region that was proximal to the head of the pancreas. The mean procedure time of EUS-GE was 28.4 ± 3.85 minutes (range of 22–32 minutes). There were no adverse events, such as bleeding. Necropsy of the animals showed that all of the stents were in the correct position. The mean distance between the site of gastroenterostomy and pylorus was 34.6 ± 3.58 cm (range of 30–38 cm). Conclusions: The intestinal region that was proximal to the head of the pancreas was a suitable place for performing endoscopic ultrasound-guided gastroenterostomy. The suitability of this location should be confirmed by further animal and clinical studies.
Potentially repurposable drugs for COVID-19 identified from SARS-CoV-2 Host Protein Interactome
Authors: Karunakaran Kalyani B. , Balakrishnan N. , Ganapathiraju Madhavi 
Published: May 2020

Abstract
We previously presented the protein-protein interaction network (‘HoP Interactome’) of 332 host proteins that were identified to interact with 27 nCoV19 viral proteins by Gordon et al. Here, we studied drugs targeting the proteins in this interactome to identify whether any of them may potentially be repurposable against SARS-CoV-2. We studied each of the drugs using the BaseSpace Correlation Engine and identified those that induce gene expression profiles negatively correlated with SARS/COVID-associated expression profile. This analysis resulted in 24 drugs whose differential gene expression (drug versus normal) had an anti-correlation with differential expression for SARS/COVID-19 (viral infection versus normal). These included drugs that were found to be effective against SARS-CoV-2 in cell-based assays, those that are being tested for their clinical activity against SARS-CoV-2 by others, those with proven activity against SARS-CoV/MERS-CoV, broad-spectrum antiviral drugs, and those identified/prioritized by other computational re-purposing studies. In summary, our integrated computational analysis of the HoP interactome in conjunction with drug-induced transcriptomic data resulted in drugs that may be repurposable for COVID-19.