bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microwave‐assisted extraction (MAE) combined with gas chromatography–mass spectrometry (GC–MS) for determination of volatile small molecules to evaluate compatibility of antimicrobial peptide PL‐5 spray with packaging materials
Authors: Liu Chu , Yu Xiangyong , Meng Zhaorui , Zhao Ning , Bai Fujuan , Zhao Longshan 
Published: November 2019

AbstractA simple and efficient method involving microwave‐assisted extraction (MAE) combined with GC–MS was established to determine 1,3‐di‐tert‐butylbenzene (DBB), 2,4‐di‐tert‐butylphenol (DBP), 3,5‐di‐tert‐butyl‐4‐hydroxybenzaldehyde (DBHBA) for evaluating the compatibility of antimicrobial peptide PL‐5 spray with drug‐packaging materials. In this study, the antimicrobial peptide PL‐5 spray was purified using a Welchrom C18 column, and the high‐density polyethylene spray bottle with liquid collection tube was first mixed with absolute ethanol, which would be subjected to MAE for further measurement by GC–MS. Various experimental parameters were systematically optimized, and good linearities were obtained within the range of 0.05–1.00 μg/mL for DBB and DBHBA and 0.50–10.00 μg/mL for DBP, with limits of detection (LODs) of 0.99 ng/mL (DBB), 16.34 ng/mL (DBP), and 1.64 ng/mL (DBHBA). Satisfactory recoveries that ranged from 96.0% to 107.2% were acquired, and the relative standard deviation was ≤ 4.7%. The results showed that the maximum daily usage of DBB, DBP, and DBHBA was 9.859, 163.445, and 16.399 ng, respectively, which was far below the corresponding permitted daily exposure values according to the safety assessment, indicating that the migration of analytes did not bring any potential safety risk. The compatibility between the drug and the packaging materials was favorable.
Sustainable entrepreneurship, innovation, and business models: Integrative framework and propositions for future research
Authors: Lüdeke‐Freund Florian 
Published: November 2019

AbstractThis article introduces the business models for sustainability innovation (BMfSI) framework to study how business models mediate between sustainability innovations and business cases for sustainability. The BMfSI framework integrates two major perspectives (implicitly) found in the sustainable business model literature. The first is the agency perspective. It takes into consideration that some form of agency is needed, that is, “someone” who takes decisions and acts. Sustainable entrepreneurs are discussed as those agents who align their new or existing business models with sustainability innovations in order to be successful in business and to create value with and for stakeholders. The second perspective is the systems perspective, which acknowledges that business models are always embedded within sociotechnical contexts through which, for example, public policies, private financing, or stakeholder interests influence whether and how business models can be developed. The agency and systems perspectives are integrated in the so‐called business model mediation space. This theoretical notion embraces the decisions and activities pursued by sustainable entrepreneurs as they align their business models with sustainability innovations on the one hand and the influence of environmental contingencies, barriers, and stakeholders from the sociotechnical context on the other hand. The paper concludes with propositions for future research derived from the BMfSI framework.
Phase III randomized, placebo‐controlled, double‐blind study of monosialotetrahexosylganglioside for the prevention of oxaliplatin‐induced peripheral neurotoxicity in stage II/III colorectal cancer
Authors: Wang De‐shen , Wang Zhi‐qiang , Chen Gong , Peng Jie‐wen , Wang Wei , Deng Yan‐hong , Wang Feng‐hua , Zhang Jian‐wei , Liang Han‐lin , Feng Fen , Xie Chuan‐bo , Ren Chao , Jin Ying , Shi Si‐mei , Fan Wen‐hua , Lu Zhen‐hai , Ding Pei‐rong , Wang Feng , Xu Rui‐hua , Li Yu‐hong 
Published: November 2019

AbstractBackgroundMonosialotetrahexosylganglioside (GM1) is a neuroprotective glycosphingolipid that repairs nerves. Oxaliplatin‐based chemotherapy is neurotoxic. This study assessed the efficacy of GM1 for preventing oxaliplatin‐induced peripheral neurotoxicity (OIPN) in colorectal cancer (CRC) patients receiving oxaliplatin‐based chemotherapy.MethodsIn total, 196 patients with stage II/III CRC undergoing adjuvant chemotherapy with mFOLFOX6 were randomly assigned to intravenous GM1 or a placebo. The primary endpoint was the rate of grade 2 or worse cumulative neurotoxicity (NCI‐CTCAE). The secondary endpoints were chronic cumulative neurotoxicity (EORTC QLQ‐CIPN20), time to grade 2 neurotoxicity (NCI‐CTCAE or the oxaliplatin‐specific neuropathy scale), acute neurotoxicity (analog scale), rates of dose reduction or withdrawal due to OIPN, 3‐year disease‐free survival (DFS) and adverse events.ResultsThere were no significant differences between the arms in the rate of NCI‐CTCAE grade 2 or worse neurotoxicity (GM1: 33.7% vs placebo: 31.6%; P = .76) or neuropathy measured by the EORTC QLQ‐CIPN20 or time to grade 2 neurotoxicity using NCI‐CTCAE and the oxaliplatin‐specific neuropathy scale. GM1 substantially decreased participant‐reported acute neurotoxicity (sensitivity to cold items [P < .01], discomfort swallowing cold liquids [P < .01], throat discomfort [P < .01], muscle cramps [P < .01]). The rates of dose reduction or withdrawal were not significantly different between the arms (P = .08). The 3‐year DFS rates were 85% and 83% in the GM1 and placebo arms, respectively (P = .19). There were no differences in toxicity between the arms.ConclusionPatients receiving GM1 were less troubled by the symptoms of acute neuropathy. However, we do not support the use of GM1 to prevent cumulative neurotoxicity. (ClinicalTrials.gov number, NCT02251977).
Associations of reproductive factors with breast cancer prognosis and the modifying effects of menopausal status
Authors: Zhang Jia‐Yi , Wang Mei‐Xia , Wang Xiang , Li Yue‐Lin , Liang Zhuo‐Zhi , Lin Ying , Liu Qiang , Xie Xiao‐Ming , Tang Lu‐Ying , Ren Ze‐Fang 
Published: November 2019

AbstractReproductive factors associated with breast cancer risk may also affect the prognosis. This study aimed to evaluate the associations of multiple reproductive factors with breast cancer prognosis and the modifying effects of menopausal status. We obtained data from 3805 breast cancer patients recruited between October 2008 and June 2016 in Guangzhou. The subjects were followed up until 30 June 2018. The hazard ratios (HRs) and 95% confidence intervals (95% CIs) were calculated using multivariate Cox models to estimate the associations. It was found that there were U‐shaped patterns for the associations of age at first birth and durations from first/last birth to diagnosis with breast cancer prognosis. The adverse effects of old age at first birth [>30 years vs 23‐30 years, HR (95% CI): 1.59 (1.01‐2.50)] and long intervals from first [≥20 years vs 10‐19 years, HR (95% CI): 1.55 (1.07‐2.27)] or last [≥20 years vs 10‐19 years, HR (95% CI): 1.63 (1.08‐2.46)] birth to diagnosis on progression‐free survival (PFS) were significantly more pronounced among premenopausal women. Additionally, long interval (>5 years) between first and second birth was associated with a better PFS [HR (95% CI): 0.64 (0.42‐0.97)]. These results suggested that age at first birth, durations from first/last birth to diagnosis, and intervals between first and second birth should be taken into account when following the patients and assessing the prognosis of breast cancer, particularly for premenopausal patients. These findings would also have implications for further insight into the mechanisms of breast cancer development.
Rationale and design of a navigator‐driven remote optimization of guideline‐directed medical therapy in patients with heart failure with reduced ejection fraction
Authors: Blood Alexander J. , Fischer Christina M. , Fera Liliana E. , MacLean Taylor E. , Smith Katelyn V. , Dunning Jacqueline R. , Bosque‐Hamilton Joshua W. , Aronson Samuel J. , Gaziano Thomas A. , MacRae Calum A. , Matta Lina S. , Mercurio‐Pinto Ana A. , Murphy Shawn N. , Scirica Benjamin M. , Wagholikar Kavishwar , Desai Akshay S. 
Published: November 2019

AbstractAlthough optimal pharmacological therapy for heart failure with reduced ejection fraction (HFrEF) is carefully scripted by treatment guidelines, many eligible patients are not treated with guideline‐directed medical therapy (GDMT) in clinical practice. We designed a strategy for remote optimization of GDMT on a population scale in patients with HFrEF leveraging nonphysician providers. An electronic health record‐based algorithm was used to identify a cohort of patients with a diagnosis of heart failure (HF) and ejection fraction (EF) ≤ 40% receiving longitudinal follow‐up at our center. Those with end‐stage HF requiring inotropic support, mechanical circulatory support, or transplantation and those enrolled in hospice or palliative care were excluded. Treating providers were approached for consent to adjust medical therapy according to a sequential, stepped titration algorithm modeled on the current American College of Cardiology (ACC)/American Heart Association (AHA) HF Guidelines within a collaborative care agreement. The program was approved by the institutional review board at Brigham and Women's Hospital with a waiver of written informed consent. All patients provided verbal consent to participate. A navigator then facilitated medication adjustments by telephone and conducted longitudinal surveillance of laboratories, blood pressure, and symptoms. Each titration step was reviewed by a pharmacist with supervision as needed from a nurse practitioner and HF cardiologist. Patients were discharged from the program to their primary cardiologist after achievement of an optimal or maximally tolerated regimen. A navigator‐led remote management strategy for optimization of GDMT may represent a scalable population‐level strategy for closing the gap between guidelines and clinical practice in patients with HFrEF.
End‐of‐life care among adolescent and young adult patients with cancer living in poverty
Authors: Roeland Eric J. , Lindley Lisa C. , Gilbertson‐White Stephanie , Saeidzadeh Seyedehtanaz , Currie Erin R. , Friedman Sarah , Bakitas Marie , Mack Jennifer W. 
Published: November 2019

BackgroundTo the authors' knowledge, end‐of‐life (EOL) care outcomes among adolescents and young adults (AYAs) with cancer who are living in poverty remain poorly understood. The primary aim of the current study was to examine the effect of poverty on EOL care for AYA patients with cancer.MethodsThe authors conducted a multisite, retrospective study of AYA patients with cancer aged 15 to 39 years who died between January 2013 and December 2016 at 3 academic sites. Medical record‐based EOL care outcomes included hospice referral, palliative care (PC) consultation, cancer treatment within the last month of life, and location of death. Two measures of poverty were applied: 1) zip code with a median income ≤200% of the federal poverty level; and 2) public insurance or lack of insurance. Logistic regression analyses were conducted.ResultsA total of 252 AYA cancer decedents were identified. Approximately 41% lived in a high‐poverty zip code and 48% had public insurance or lacked insurance; approximately 70% had at least 1 poverty indicator. Nearly 40% had a hospice referral, 60% had a PC consultation (76% on an inpatient basis), 38% received EOL cancer treatment, and 39% died in the hospital. In bivariable analyses, AYA patients living in low‐income zip codes were found to be less likely to enroll in hospice (P ≤ .01), have an early PC referral (P ≤ .01), or receive EOL cancer treatment (P = .03), although only EOL cancer treatment met statistical significance in multivariable models. No differences with regard to location of death (P = .99) were observed.ConclusionsAYA patients with cancer experience low rates of hospice referral and high rates of in‐hospital death regardless of socioeconomic status. Future studies should evaluate early inpatient PC referrals as a possible method for improving EOL care.
Economic impact of the POP mode on distribution network reconstruction in the ‘coal‐to‐electricity’ project of the grid company in China: a new electricity transaction mode
Authors: Zhang Caiqing , Xu Lingli 
Published: November 2019

AbstractThe ‘coal to electricity’ carried out by the grid company has had poor economic performance during its life cycle. This paper aims to investigate the economic impact of the package deal of off‐peak electricity transaction mode (POP) on the ‘coal‐to‐electricity’ project in comparison with peak and valley electricity price (PVP). The incremental net present value and the incremental benefit–cost ratio are selected as the main economical evaluating indicators. Taking a coal‐to‐electricity project in a region of Beijing, China, as an example to study the economic benefit of the grid company in POP. The results indicate that the economic benefit of the grid company is increased by 48% in POP compared to that in PVP. The incremental benefit–cost ratio is less than 1, which demonstrates that POP is conducive to improving the current loss status of the grid company. It is helpful to raise the grid company's enthusiasm for conducting the coal‐to‐electricity project. Finally, corresponding suggestions are put forward to help the grid company in improving the negative economic benefit. © 2019 Society of Chemical Industry and John Wiley & Sons, Ltd.
Light‐guided renal cyst fenestration during laparoscopic ureterocalicostomy in a patient with left ureteropelvic junction obstruction
Authors: Yamasaki Kazumitsu , Uchida Masahiro , Nishijima Yukiko , Hoshi Akio , Nishiyama Hiroyuki 
Published: November 2019

IntroductionLaparoscopic ureterocalicostomy is a useful alternative to laparoscopic pyeloplasty for treating ureteropelvic junction obstruction under certain conditions. One concern regarding this technique is the inevitability of amputation of the renal lower pole to expose the lower renal calyx.Case presentationA 43‐year‐old man who presented ureteropelvic junction obstruction and multiple renal cysts underwent laparoscopic pyeloplasty, which could not be performed because of the intrarenal ureteropelvic junction. We switched the surgical technique to modified laparoscopic ureterocalicostomy, wherein amputation of the lower renal pole was substituted with fenestration of a renal cyst under the guidance of ureteroscopic light. Computed tomography performed 2 months postoperatively showed good patency of the anastomosis.ConclusionLight‐guided laparoscopic renal cyst fenestration followed by ureterocalicostomy is feasible in patients with ureteropelvic junction obstruction and lower pole renal cysts adjacent to the lower renal calyx.
A novel mutation in USF1 gene is associated with familial combined hyperlipidemia
Authors: Taghizadeh Eskandar , Mirzaei Farzaneh , Jalilian Nazanin , Ghayour Mobarhan Majid , Ferns Gordon A. , Pasdar Alireza 
Published: November 2019

AbstractBackgroundFamilial combined hyperlipidemia or FCHL is one of the most common genetic causes of hyperlipidemia and is associated with elevation of cholesterol, triglycerides or both, and increased serum apolipoprotein B (apoB). Linkage analysis and next generation sequencing have been successfully used for identifying rare genetic variants that have moderate‐to‐large effects.MethodsWe characterized a large pedigree from a proband identified following recruitment into the MASHAD study, in northeast Iran, with FCHL accompanied by early‐onset coronary artery disease. We used linkage analysis for several candidate regions in previous studies such as 1q21‐23, 11q23, and 8p, and then whole‐exome sequencing to identify the disease‐associated gene in this family.ResultsWe identified a novel variant in the USF1 gene, leading to a substitution of a tryptophan for arginine at position 196. Arg196Trp co‐segregated in all the affected family members in this pedigree with clinical syndrome and was not found in any unaffected family members of this pedigree, or in unrelated controls.ConclusionsWe speculate that this mutation [Arg196Trp] in the USF1 gene might be associated with FCHL and early‐onset coronary heart disease in this family. However, the substantial mechanism requires further investigation. These findings indicate that USF1 plays an important role in the biological pathways associated with lipid metabolism.
Identification of long non‐coding RNA MVIH as a prognostic marker and therapeutic target in acute myeloid leukemia
Authors: Jiang Zhiyong , Yu Qinghong , Luo Xinguo 
Published: November 2019

AbstractBackgroundThis study aimed to investigate the correlation of long non‐coding RNA microvascular invasion in hepatocellular carcinoma (lncRNA MVIH) with disease risk, disease conditions, and prognosis of acute myeloid leukemia (AML), and also to investigate the influence of lncRNA MVIH on AML cell activities in vitro.MethodsA total of 212 AML patients and 70 controls were consecutively recruited. Their bone marrow mononuclear cells (BMMCs) were isolated, and lncRNA MVIH was detected by reverse transcription quantitative‐polymerase chain reaction. In AML patients, complete remission (CR), event‐free survival (EFS), and overall survival (OS) were assessed. In vitro, lncRNA MVIH expression in AML cell lines was determined, and the effect of lncRNA MVIH on AML cell proliferation and apoptosis was assessed.ResultsLncRNA MVIH expression was increased in AML patients compared to controls, and receiver operating characteristic curve showed that lncRNA MVIH predicted elevated AML risk (area under curve: 0.742 [95% CI: 0.674‐0.810]). In AML patients, no correlation of lncRNA MVIH expression with French‐American‐British classification was observed, while lncRNA MVIH high expression correlated with worse risk stratification. Moreover, lncRNA MVIH expression negatively correlated with CR achievement, EFS and OS. In vitro, lncRNA MVIH was overexpressed in AML cell lines (KG‐1, ME‐1, and HT‐93) compared to normal BMMCs. Furthermore, lncRNA MVIH downregulation reduced KG‐1 cell proliferation but increased apoptosis, whereas lncRNA MVIH upregulation raised HL‐60 cell proliferation but decreased apoptosis.ConclusionLncRNA MVIH may not only serve as a prognostic marker but also act as a therapeutic target in AML.
Outcome of acute pancreatitis in octogenarians: A retrospective study
Authors: Di Mauro Davide , Wijesurendere Chinthaka N , Attanasio Andrea , Fulgenzi Claudia A M , Elkhuffash Iyad , Ricciardi Edoardo , Wajed Shahjehan , Manzelli Antonio 
Published: November 2019

Background and AimAcute pancreatitis (AP) is a common disease, but data on outcomes in octogenarians are scarce in the literature. The aim of this study is to analyze results from patients aged 80 years old and over who were treated for AP at a single center.MethodsPatients aged 80 years and older diagnosed with AP from April 2010 to October 2015 were considered. Demographics, American Society of Anesthesiologists (ASA) score, Charlson Comorbidity Index (CCI), serum biochemistry at 24 and 48 h after admission, and revised Atlanta severity score were analyzed and correlated with hospital mortality rate and length of stay using the multiple regression and Kaplan–Meier tests.ResultsA total of 100 consecutive patients were included in the study. There were 52 women, and the mean age was 87.5 years (range 80–95). Gallstones were the most common cause of AP (69.7%). The ASA score was ≥III in 51 patients. Eight patients had severe, disease and all of them died in hospital. A CCI > 4 was associated with higher disease severity and mortality (P < 0.00001). The median hospital stay was 9 days (range 1–59). Longer hospital stay was associated with serum C‐reactive protein ≥242 mg/L (P = 0.01) and serum albumin ≤30 g/L (P = 0.01) at 48 h. Over a 5‐year period, 22% of patients were readmitted to hospital with recurrent AP. Gallstones were the main cause of disease (63.6%).ConclusionsAP in octogenarians has low mortality. Higher death rate is associated with disease severity. In the presence of gallstone disease, cholecystectomy is recommended whenever possible as the risk of disease recurrence is significant.
Effects of defects in hybrid sheet moulding compound – Evaluation of defects and the impact on mechanical properties
Authors: Schäferling M. , Häfner B. , Lanza G. , Trauth A. , Weidenmann K. , Thompson M. 
Published: November 2019

AbstractSheet moulding compound is a widely used fibre‐reinforced material. Generally, it consists of discontinuous glass fibres in a thermoset matrix system. Due to the finite fibre length, mechanical properties of structural components are limited. To overcome this drawback, sheet moulding compound is locally reinforced with a unidirectional carbon fibre sheet moulding compound material in the approach presented in this contribution. The manufacturing of this hybrid material consisting of discontinuous glass fibre sheet moulding compound and continuous carbon fibre sheet moulding compound can result in different defects, such as folds or fibre misalignments. These defects may affect mechanical properties of the hybrid material. Consequently, this article deals with the investigation and analysis of defective hybrid sheet moulding compound components, which were examined by means of tensile tests. Results point out that investigated defects have different effects on mechanical properties. However, independent from the type of defect, mechanical properties were reduced. With a reduction of 68.86 %, folds have one of the greatest influences on tensile strength. In addition, depending on the angle deviation, even greater reductions can occur. Furthermore, the reduction of the mechanical properties can be identified clearly with increasing angle deviation.
T1‐corrected quantitative chemical shift‐encoded MRI
Authors: Wang Xiaoke , Colgan Timothy J. , Hinshaw Louis A. , Roberts Nathan T. , Bancroft Leah C. Henze , Hamilton Gavin , Hernando Diego , Reeder Scott B. 
Published: November 2019

PurposeTo develop and validate a T1‐corrected chemical‐shift encoded MRI (CSE‐MRI) method to improve noise performance and reduce bias for quantification of tissue proton density fat‐fraction (PDFF).MethodsA variable flip angle (VFA)‐CSE‐MRI method using joint‐fit reconstruction was developed and implemented. In computer simulations and phantom experiments, sources of bias measured using VFA‐CSE‐MRI were investigated. The effect of tissue T1 on bias using low flip angle (LFA)‐CSE‐MRI was also evaluated. The noise performance of VFA‐CSE‐MRI was compared to LFA‐CSE‐MRI for liver fat quantification. Finally, a prospective pilot study in patients undergoing gadoxetic acid‐enhanced MRI of the liver to evaluate the ability of the proposed method to quantify liver PDFF before and after contrast.ResultsVFA‐CSE‐MRI was accurate and insensitive to transmit B1 inhomogeneities in phantom experiments and computer simulations. With high flip angles, phase errors because of RF spoiling required modification of the CSE signal model. For relaxation parameters commonly observed in liver, the joint‐fit reconstruction improved the noise performance marginally, compared to LFA‐CSE‐MRI, but eliminated T1‐related bias. A total of 25 patients were successfully recruited and analyzed for the pilot study. Strong correlation and good agreement between PDFF measured with VFA‐CSE‐MRI and LFA‐CSE‐MRI (pre‐contrast) was observed before (R2 = 0.97; slope = 0.88, 0.81–0.94 95% confidence interval [CI]; intercept = 1.34, −0.77–1.92 95% CI) and after (R2 = 0.93; slope = 0.88, 0.78–0.98 95% CI; intercept = 1.90, 1.01–2.79 95% CI) contrast.ConclusionJoint‐fit VFA‐CSE‐MRI is feasible for T1‐corrected PDFF quantification in liver, is insensitive to B1 inhomogeneities, and can eliminate T1 bias, but with only marginal SNR advantage for T1 values observed in the liver.