bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adsorptive separation of propionic acid from aqueous medium using efficient anion exchange resins in batch and fixed bed column systems
Authors: Marti Mustafa Esen , Isik Murat , Zeidan Hani 
Published: December 2024

AbstractThe recovery of propionic acid (PA) from aqueous medium using a strongly basic, Lewatit M‐600 (LM‐600), and a weakly basic, Lewatit MP‐62 (LMP‐62), anion exchanger was investigated. Medium conditions such as pH, temperature, PA concentration, and resin dose affected the performance of the process. The highest capacities were achieved at pH 5 and 2 with LM‐600 and LMP‐62, respectively. Equilibrium was reached in 35 min, and the process followed the pseudo‐second‐order kinetics for both anion exchangers. LMP‐62 was more effective at pH values lower than 5. The exothermic process was found to be spontaneous. The maximum capacities of the strong and weak basic exchangers in batch experiments were 135.7 and 363 mg/g, respectively. However, the breakthrough capacities obtained in fixed bed systems were lower than those attained in batch systems (94.75 and 123.73 mg/g for LM‐600 and LMP‐62, respectively), and the column was successfully regenerated using 0.6 M NaOH. The Freundlich isotherm model yielded the highest determination coefficients in the isotherm analysis, suggesting that physical forces between PA and resins primarily drive the process.
Synthesis of New Enantiopure Aminoalcohol Fluorenes as Promising Antimalarial Compounds
Authors: Tisnerat Camille , Schneider Jérémy , Mustière Romain , Herrero Aurélie , Momha René , Damiani Céline , Agnamey Patrice , Totet Anne , Marchivie Mathieu , Guillon Jean , Dassonville‐Klimpt Alexandra , Sonnet Pascal 
Published: December 2024

AbstractHerein, we report the design, synthesis, and characterisation of a new library of enantiopure aminoalcohol fluorenes, as well as their in vitro evaluation for biological properties, including activity against two strains of P. falciparum (3D7 and W2) and cytotoxicity on the HepG2 cell line. All tested compounds exhibited good to excellent antimalarial potency with IC50 values ranging from 0.7 to 70.2 nM whatever the strain. Interestingly, most compounds showed equal or better antimalarial activity compared to the reference drugs lumefantrine, mefloquine and chloroquine. Despite moderate cytotoxicity in the micromolar range, all aminoalcohol fluorenes displayed an excellent selectivity index higher than 100 due to strong antimalarial activity. Furthermore, we report in silico analyses of physicochemical and pharmacokinetic properties for all compounds, highlighting the drug‐likeness of compound 10 and its promising potential for further studies.
A Multi‐Workflow Scheduling Approach With Explicit Evolutionary Multi‐Objective Multi‐Task Optimization Algorithm in Cloud Environment
Authors: Zhang Qiqi , Li Bohui , Geng Shaojin , Cai Xingjuan 
Published: December 2024

ABSTRACTWorkflow tasks in the cloud environment are the abstraction and decomposition of large‐scale and complex tasks in real‐world scenarios, so cloud workflow scheduling problems have important research significance. However, most of the existing cloud workflow scheduling schemes are aimed at a single workflow, and do not make reasonable use of the commonality or complementary knowledge between similar tasks. Moreover, most cloud workflow scheduling models mainly focus on a few objectives such as time or cost, which is not comprehensive enough. Therefore, this paper first proposes a multi‐objective cloud workflow scheduling model, which solves the maximum completion time, execution cost and energy consumption as three objectives during task execution. Secondly, to efficiently handle multiple similar cloud workflow scheduling tasks at the same time, this paper treats various cloud workflow scheduling issues as distinct tasks, establishes a multi‐task cloud workflow scheduling framework that aims for the same goal while accommodating workflows of differing scales, and a multi‐objective evolutionary multi‐task optimization algorithm based on elite selection (MOEMT‐ES) is designed to solve the above scheduling model. Finally, through algorithm comparison experiments on the CEC2017 evolutionary multi‐task optimization competition benchmark problem and multi‐workflow test problem, MOEMT‐ES shows superior competitiveness.
Grid‐Forming Interlinking Converter With Fault‐Ride‐Through Capability in Islanded Hybrid AC/DC Microgrids
Authors: Shen Xia , Shen Chao , Zhao Feng , Huang Wen 
Published: December 2024

ABSTRACTWith the expansion of hybrid AC/DC microgrids (MGs), the AC and DC subgrids should be able to maintain interconnection through interlinking converter (IC) under short‐circuit faults to avoid the system instability caused by power mutation. Conventional IC control methods have given insights into the current restraining between two subgrids but neglect the transient voltage/frequency support requirement, especially under islanded operation mode. This paper proposes a grid‐forming IC control with fault‐ride‐through (FRT) capability. An fn‐Pic‐Vdc control architecture is presented to regulate power exchanges among AC and DC subgrids with solid AC bus voltage supports under the premise of DC voltage stable. Additionally, the Lyapunov large disturbance stability equation is established, and the safe operating boundaries of key parameters are described based on the Takagi–Sugeno (TS) model criterion. It is revealed that within certain range, the proper DC voltage feedback control parameters in IC could enhance the system stability and the power support capability of DC subgrid to the AC side. Finally, comparative case studies are conducted to validate effectiveness of the proposed control strategy.
Brain‐Like Biomimetic Circuit Design Based on Memristor
Authors: Liu Lixin 
Published: December 2024

ABSTRACTIn this work, inspired by the neural mechanisms of the human brain, a brain‐like biomimetic circuit based on visual information processing is proposed. The circuit is mainly composed of test module, cognitive module, categorization module, and output module. The cognitive module mimics the function of memory neurons in the brain, generating memory potentials to store information while receiving visual information stimuli. The categorization module mimics the function of the visual cortex, enabling the conversion from memory to action. I verified the feasibility of this circuit for information processing using LTspice. This study provides new ideas and insights for the future development of visual information processing technology for electronic products.
Behavioral Weight Loss Treatment Promotes Weight Loss by Increasing Eating Disorder Symptoms: A Response to Grilo & Pittman (2024)
Authors: Levinson Cheri A. , Hernández Juan C. , Sandoval‐Araujo Luis E. 
Published: December 2024

ABSTRACTWe provide commentary on the Grilo and Pittman (2024). Exploring Dietary Restraint as a Mediator of Behavioral and Cognitive‐Behavioral Treatments on Outcomes for Patients With Binge‐Eating Disorder With Obesity article published in the International Journal of Eating Disorders. Grilo and Pittman show that weight loss in the Behavioral Weight Loss Treatment condition is mediated by an increase in rigid restraint, whereas binge eating is not mediated by rigid restraint. They conclude that this result is a positive outcome for patients with binge‐eating disorder and shows that BWL is not harmful in this population. We argue that increasing rigid restraint equates to increasing eating disorder symptoms and is harmful in any population, but specifically in those with an already diagnosed eating disorder. In addition, we point out the major limitations of no follow‐up data in the mediation report, no measurement of additional eating disorder symptoms that could represent diagnostic migration, and lack of inclusion of weight stigma as additional problems with the stated conclusions. We recommend that the field moves away from measurement of weight loss as an outcome in those with eating disorders and carefully consider what it means to increase restraint/restriction in eating disorder populations.
Analysis of the Impact of Agriculture and Logging on Forest Habitat Structure in the Ankasa and Bia Conservation Area of Ghana
Authors: Ashiagbor George , Abubakar Sinka Khadijah , Inusah Sandra Sawdiatu , Adjapong Abena Owusu , Osei Gideon Nyamekye , Laari Prosper Basommi 
Published: December 2024

ABSTRACTGhana's Ankasa (ACA) and Bia Conservation Area (BCA) are experiencing forest loss due to agricultural conversions. However, there is limited comprehensive analysis of these conversions and their impact on the forest habitat structure in these areas. This study aims to analyse anthropogenic‐induced forest habitat loss and fragmentation in the ACA and BCA. Landsat images for the epochs 1980, 2000 and 2020 were pre‐processed, and subsets were created using a 5 km buffer of the two conservation areas. The images were classified into forest, agriculture and built‐up. The classified images were analysed for landscape pattern changes using patch density (PD), edge density (ED), largest patch index (LPI), landscape shape index (LSI) and aggregation index (AI). The Wilcoxon signed‐rank test was used to analyse changes in landscape structure. The results indicate that forest cover in the ACA decreased by 16.4% from 100,941.6 ha in 1980 to 84,410.6 ha in 2020, and in the BCA, it decreased by 14.4% from 70,211.8 to 60,117.36 ha. There was no encroachment from agricultural activities within the conservation areas, but agricultural activities, mainly cocoa expansion, increased within the 5 km buffer, leading to the decline in forest cover. The landscape analysis shows that the forest patches have become fragmented, disjointed and isolated, especially within the 5 km buffer. This is indicated by increased PD, decreased AI, decreased LPI and increased ED. The immediate loss of forest habitat cover in the off‐reserve landscape and the significant levels of forest fragmentation, resulting in the loss of forest connectivity, have significant implications for wildlife conservation. Ecological restoration and conservation efforts are needed to reduce this potential impact. Ecologists have recommended transitioning from monoculture cocoa to cocoa agroforestry to improve forest habitat connectivity within adjoining cocoa farms in the landscapes of these conservation areas.
SHIP‐1 Differentially Regulates IgE‐Induced IL‐10 and Antiviral Responses in Human Monocytes
Authors: Solleti Siva Kumar , Matthews Bailey E. , Wu Jingyi , Rowe Regina K. 
Published: December 2024

ABSTRACTIgE‐mediated stimulation of monocytes regulates multiple cellular functions including cellular maturation, cytokine release, antiviral responses, and T‐cell differentiation. Expression of the high‐affinity IgE receptor, FcεRI, is closely linked to serum IgE levels and atopic disease. The signaling molecules regulating FcεRI effector functions have been well studied in mast cells and basophils; however, less is known about the signaling and regulatory mechanisms in monocytes. This study sought to identify regulators of IgE‐mediated cytokine release in human monocytes. SHIP‐1 was identified as a negative regulator of IgE‐induced IL‐10 production. It was also determined that IgE‐mediated stimulation and SHIP‐1 inhibition decreased antiviral IP‐10 production after liposomal poly(I:C) stimulation, indicating differential regulation by SHIP‐1 in IgE‐driven and antiviral response pathways. SHIP‐1 and NF‐κB were activated following IgE‐mediated stimulation of monocytes, and NF‐κB activation was related to both SHIP‐1 and FcεRIα cellular expression levels. To our knowledge, this is the first study to identify a role for SHIP‐1 in regulating IgE‐mediated and antiviral responses in human monocytes. Given the importance of monocytes in inflammation and immune responses, a better understanding of the signaling and regulatory mechanisms downstream of the FcεRI receptor could lead to new therapeutic targets in allergic disease.
An Overview of 3‐Phenylpropyl Acetate: A Multifaceted Fragrance and Flavouring Compound
Authors: Hanumesh Parimala , Rangappa Shobith 
Published: December 2024

ABSTRACT3‐Phenylpropyl acetate, a small molecule with significant importance in the realm of flavours and fragrances, is consumed globally in quantities ranging from 1 to 10 tons per year. Given its widespread use, a thorough safety assessment is imperative. This review delves into the toxicological implications associated with 3‐phenylpropyl acetate, focusing on various aspects such as mutagenicity, genotoxicity, repeated dose toxicity, reproductive toxicity, skin sensitisation, phototoxicity/photoallergenicity, local respiratory toxicity, as well as biodegradation and ecotoxicity. By evaluating the available data on these parameters, a comprehensive risk assessment can be conducted to ensure the safe utilisation of this compound in various applications.
Inhibitory Postsynaptic Potentials Participate in Intracellular and Extracellular Theta Rhythms in the Hippocampus: A Personal Narrative
Authors: Leung L. Stan , Yim Chi Yiu Conrad 
Published: December 2024

ABSTRACTThe hypothesis that the hippocampal theta rhythm consists of inhibitory postsynaptic potentials (IPSPs) was critical for understanding the theta rhythm. The dominant views in the early 1980s were that intracellularly recorded theta consisted of excitatory postsynaptic potentials (EPSPs) with little participation by IPSPs, and that IPSPs generated a closed monopolar field in the hippocampus. I (Leung) conceived of a new model for generation of the hippocampal theta rhythm, with theta‐rhythmic IPSPs as an essential component, and thus sought to reinvestigate the relation between theta and IPSPs quantitatively with intracellular and extracellular recordings. The intracellular recordings were performed by Leung and Yim in the laboratory of Kris Krnjević at McGill University. Using protocols of passing steady‐state holding currents and injection of chloride ions, the intracellular theta and IPSP in a CA1 neuron typically showed the same reversal potential and correlated change in amplitude. Low‐intensity stimulation of the alveus evoked an antidromic action potential in CA1 neurons, identifying them as pyramidal cells with output axons in the alveus, which then activated a feedback IPSP with almost no excitatory component. Theta‐rhythmic somatic inhibition, together with phase‐shifted theta‐rhythmic distal apical dendritic excitation were proposed as the two dipoles that generate a gradual extracellular theta phase shift in the CA1 apical dendritic layer. The distal apical excitation driven by the entorhinal cortex was proposed to be atropine‐resistant and dominated during walking in rats. Other than serving a conventional role in limiting excitation, rhythmic proximal inhibition and distal dendritic excitation provide varying phasic modulation along the soma‐dendritic axis of pyramidal cells, resulting in theta phase‐dependent synaptic plasticity and gamma oscillations, which are likely involved in cognitive processing.
A Comparison of Sleep and Settle Behaviours Across Twins and Singletons at 5 Months of Age
Authors: Viktorsson Charlotte , Ronald Angelica , Falck‐Ytter Terje 
Published: December 2024

ABSTRACTTwin studies are important for research on genetic and environmental influences on child development, but it is imperative to test whether findings can be generalised from twins to singletons. Since the first months of life are defined by the emergence of important sleep behaviours, we compared 451 (54.8% females) twins and 77 singletons (48.1% females) on a range of sleep, settle and crying behaviours at 5 months of age. No significant differences were found regarding duration of crying or time until settled. However, singletons were reported to wake up more frequently during nighttime than twins (F(1, 509) = 35.10, p < 0.001, ηp2 = 0.065), suggesting that, when reported in twin studies, this measure might be slightly underestimated at a mean level in relation to singletons. In conclusion, despite the unique challenges and additional caregiver load of infant twins, there seem to be few differences between twins and singletons regarding parent‐reported settle and crying behaviours in early infancy.
Mother–Adolescent Relationship and Psychological Distress During the COVID‐19 Pandemic: A Longitudinal Study
Authors: Sakai Atsushi , Murohashi Hiroto , Watanabe Seiji 
Published: December 2024

ABSTRACTIntroductionThis study aims to investigate how mother–adolescent relationships evolved before and during the COVID‐19 pandemic and their correlation with pandemic‐related stress and adolescents' psychological distress.MethodsA longitudinal study involving 579 mother–adolescent dyads (junior high school students at Time 1; 50% male students) was conducted, with data collected before (October 2019) and during (October 2020) the pandemic in Japan. Both mothers and adolescents reported the perceived quality of their positive and conflictual relationships at each time point. At Time 2, assessments were made regarding perceived pandemic‐related stress and adolescent psychological distress.ResultsStructural equation modeling, cross‐lagged regression, and mediation analysis revealed that perceptions of relationships by both mothers and adolescents before the pandemic predicted and sustained their own and their partners' perceptions during the pandemic. Furthermore, adolescents' perceptions of positive relationships with mothers protected against adolescents' distress. Otherwise, their perceptions of conflictual relationships with mothers posed a risk for adolescents' psychological distress. Additionally, the maintenance of adolescents' higher perception of positive relationships with their mothers was mediated by their perceived higher pandemic‐related stress.ConclusionsThese findings underscore the reciprocal and additive nature of mothers' and adolescents' perceptions of relationship quality, which in turn predict adolescents' mental health during stressful situations like a pandemic. Moreover, adolescents are encouraged not to suppress negative feelings about stress, to enhance perceptions of a positive relationship perceptions with their mother.
Tuning Surface Chemistry Impacts on Cardiac Endothelial and Smooth Muscle Cell Development
Authors: Acar Yasemin , Managh Amy , Hill Eric James , Roach Paul 
Published: December 2024

ABSTRACTCardiovascular diseases (CVDs) are the leading causes of death worldwide, with approx. Twenty million deaths in 2021. Cardiovascular implants are among the most used biomaterials in the clinical world. However, poor endothelialisation and rapid thrombosis remains a challenge. Simple chemical surface modification techniques can be used to steer biological interactions without affecting the bioimplants' overall bulk characteristics such as radiopacity and flexibility. Although silanes are well studied for protein and cell interactions, the methodical investigation of cardiac endothelial cell (EC) alongside smooth muscle cell (SMC) to mimic natural arterial environments has been limited. In this study, these cells have been investigated on surfaces functionalized with methyl, amine, thiol, methacrylate, and fluorine organosilane groups. Cardiac EC and SMC growth was investigated with metabolic activity, time lapse imaging, and immunofluorescent staining techniques. The results demonstrated that the surfaces tested are able to selectively regulate the viability and growth of the cells. Aminosilane modified surfaces displayed 2‐fold higher metabolic activity with HUVEC and 2‐fold less metabolic activity with HCASMC cell lines, compared to tissue culture plastic controls. The amino‐modification outperformed all other chemistries tested in terms of ability to promote the proliferation of ECs, while importantly reducing the activity of SMCs. This report demonstrates that aminosilane modified surfaces have the potential to be utilized in novel cardiovascular implants, which could improve biological integration in the short and possibly longer‐term. The findings of this study suggest that specific chemical modifications of the surface can enhance endothelial cell activity while minimizing the proliferation of smooth muscle cells, which are often associated with thrombosis. This highlights the potential of carefully engineered surface chemistries to improve the clinical outcomes of cardiovascular implants.
The Curious Case of Eulimnogammarus cyaneus (Dybowsky, 1874): Reproductive Biology of a Widespread Endemic Littoral Amphipod From Lake Baikal
Authors: Drozdova Polina , Shatilina Zhanna , Mutin Andrei , Saranchina Alexandra , Gurkov Anton , Timofeyev Maxim 
Published: December 2024

ABSTRACTComparative studies of reproductive biology and formation of reproductive isolation need appropriate model systems, such as groups of related species. The amphipods (Crustacea: Amphipoda) of ancient Lake Baikal are an attractive group for such works, as they consist of several hundred species that radiated within the lake and have very different levels of intraspecific genetic diversity and reproduction timing. We have previously shown that one of the most widely distributed and best studied littoral species, Eulimnogammarus verrucosus (Gersfeldt, 1858), comprises cryptic species exhibiting a post‐zygotic reproductive barrier. The object of this study was Eulimnogammarus cyaneus (Dybowsky, 1874), another widespread endemic littoral Baikal species, which has a surprisingly low genetic diversity within its large geographic range. The aim of this study was to check if the populations isolated by the Angara River source, which is approximately 120‐thousand years old, are reproductively compatible. As neither prezygotic nor postzygotic barriers were found, at the moment these populations should be treated as belonging to a single species. At the same time, we found some noteworthy features of reproduction of E. cyaneus. They include successive reproductive cycles with amplexuses formed by females with juveniles in the brood pouch and deposition of unfertilized eggs by females. The former might mean that this species is a relatively promising object for a laboratory culture of Baikal amphipods. Taken together, these results contribute to the establishment of a research framework to look for the correlation between genetic divergence and biological species delimitation.
Graph curvature and local discrepancy
Authors: Horn Paul , Purcilly Adam , Stevens Alex 
Published: December 2024

AbstractIn recent years, discrete notions of curvature have been defined and exploited to understand various geometric properties of graphs; especially regarding heat flow, and spectral properties. In this paper, we study various combinatorial properties implied by satisfying the Bakry–Émery curvature dimension inequality . In particular we derive a local discrepancy inequality, similar in spirit to the expander mixing lemma from spectral graph theory, which certifies a type of “local pseudo‐randomness” of the edge set of the graph, for graphs satisfying a curvature lower bound. In addition, several other consequences are derived regarding graph connectivity and cycle statistics of the graph.