bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Ionic Liquid Thermal Storage for Solar Thermal Electric Power Systems
Authors: Wu Banqiu , Reddy Ramana G. , Rogers Robin D. 
Published: March 2020

Abstract
Feasibility of ionic liquids as liquid thermal storage media and heat transfer fluids in a solar thermal power plant was investigated. Many ionic liquids such as [C4min][PF6], [C8mim][PF6], [C4min][bistrifluromethane sulflonimide], [C4min][BF4], [C8mim][BF4], and [C4min][bistrifluromethane sulflonimide] were synthesized and characterized using thermogravimetric analysis (TGA), differential scanning calorimeter (DSC), nuclear magnetic resonance (NMR), viscometry, and some other methods. Properties such as decomposition temperature, melting point, viscosity, density, heat capacity, and thermal expansion coefficient were measured. The calculated storage density for [C8mim][PF6] is 378 MJ/m3 when the inlet and outlet field temperatures are 210°C and 390°C. For a single ionic liquid, [C4mim][BF4], the liquid temperature range is from −75°C to 459°C. It is found that ionic liquids have advantages of high density, wide liquid temperature range, low viscosity, high chemical stability, non-volatility, high heat capacity, and high storage density. Based on our experimental results, it is concluded that ionic liquids could be excellent liquid thermal storage media and heat transfer fluids in solar thermal power plant.
Heat, Mass and Fluid Flow in a Solar Reactor for Fullerene Synthesis
Authors: Guillard Tony , Flamant Gilles , Laplaze Daniel 
Published: March 2020

Abstract
A 2 kW solar furnace was used to vaporize a graphite target for fullerene synthesis. Tests were performed in a wide range of vaporization rates (0.1–4 g/h), under variable pressure and argon flow rate. Experimental results are interpreted with numerical simulation to define key parameters for large-scale synthesis of fullerenes with solar energy. We demonstrate that the vaporization process is controlled by diffusion in the temperature and pressure ranges 3000–3700 K and 70–250 hPa respectively.
Experimental data and numerical simulation suggest that in the solar reactor, fullerene yield is governed by the dilution of carbon vapor in argon and by the temperature gradient in the cooling zone. Criteria for both parameters are suggested. Consequently, these data, combined with the numerical model accounting for heat, mass and fluid flow inside the reactor, may be used for the design of large-scale solar process.
Exploring the Influence of Stimulus Events: A Case Study of Undergraduate Student Internships
Authors: McClean Cole , Odio Michael A. , Kerwin Shannon 
Published: March 2020

Internships are crucial in many sport management students’ paths to the sport industry. This mixed-methods case study sought to understand the nature of events occurring in sport management internships and the impact on two outcomes: student career decision making and subjective well-being. Pre–post internship surveys (n = 23) and follow-up interviews (n = 21) identified stimulus events, if intern expectations were met, and if career intentions or subjective well-being were shifted. For participants, stimulus events involved different aspects of the internship (e.g., tasks, supervisor, social interactions, inclusivity, and the environment), and the perceptions of outcomes related to internships varied. In line with image theory, participants followed four impact pathways, with the focus on stimulus events influencing career intentions and then well-being as a result, or conversely well-being then career intentions. The findings have important theoretical and practical implications for both sport management educators and organizational supervisors that can help ensure mutually beneficial experiences for all parties involved.
Early Paleocene Magnetostratigraphy and Revised Biostratigraphy of the Ojo Alamo Sandstone and Lower Nacimiento Formation, San Juan Basin, New Mexico, USA
Authors: Flynn Andrew G. , Davis Adam J. , Williamson Thomas E. , Heizler Matthew , Fenley C. William , Leslie Caitlin E. , Secord Ross , Brusatte Stephen L. , Peppe Daniel J. 
Published: March 2020

AbstractThe lower Paleocene Ojo Alamo Sandstone and Nacimiento Formation from the San Juan Basin (SJB) in northwestern New Mexico preserve arguably the best early Paleocene mammalian record in North America and is the type location for the Puercan (Pu) and Torrejonian (To) North American land mammal ages (NALMA). However, the lack of precise depositional age constraints for the Ojo Alamo Sandstone and lower Nacimiento Formation has hindered our understanding of the timing and pacing of mammalian community change in the SJB following the Cretaceous–Paleogene mass extinction. Here we produced a high-resolution age model for the Ojo Alamo Sandstone and lower Nacimiento Formation combining magnetostratigraphy and 40Ar/39Ar geochronology spanning the first ∼3.5 m.y. of the Paleocene. Mean sediment accumulation rates during C29n were relatively low (&lt;50 m/m.y.) and equalized from basin center to basin margin indicating an accommodation minimum; sediment accumulation rates approximately double (&gt;90 m/m.y.) during C28r and are highest in the basin center and lowest on basin margin, which indicates high accommodation and an increase in basin subsidence near the C29n/C28r boundary (ca. 64.96 Ma). Puercan fossil localities were restricted to C29n, Torrejonian 1 localities to C28n, and lower Torrejonian 2 localities to C27r. Our revised age model for the SJB suggests that the first appearance of To1 mammals may have been diachronous across North America, with the Torrejonian 1 mammals first appearing in the north (Montana and North Dakota) during C29n, then in middle latitudes (Utah) in C28r, and lastly in southern North America (New Mexico) in C28n.
First mid-ocean ridge-type ophiolite from the Meso-Tethys suture zone in the north-central Tibetan plateau
Authors: Tang Yue , Zhai Qing-Guo , Chung Sun-Lin , Hu Pei-Yuan , Wang Jun , Xiao Xu-Chang , Song Biao , Wang Hai-Tao , Lee Hao-Yang 
Published: March 2020

Abstract
The Meso-Tethys was a late Paleozoic to Mesozoic ocean basin between the Cimmerian continent and Gondwana. Part of its relicts is exposed in the Bangong–Nujiang suture zone, in the north-central Tibetan Plateau, that played a key role in the evolution of the Tibetan plateau before the India-Asia collision. A Penrose-type ophiolitic sequence was newly discovered in the Ren Co area in the middle of the Bangong–Nujiang suture zone, which comprises serpentinized peridotites, layered and isotropic gabbros, sheeted dikes, pillow and massive basalts, and red cherts. Zircon U-Pb dating of gabbros and plagiogranites yielded 206Pb/238U ages of 169–147 Ma, constraining the timing of formation of the Ren Co ophiolite. The mafic rocks (i.e., basalt, diabase, and gabbro) in the ophiolite have uniform geochemical compositions, coupled with normal mid-ocean ridge basalt-type trace element patterns. Moreover, the samples have positive whole-rock εNd(t) [+9.2 to +8.3], zircon εHf(t) [+17 to +13], and mantle-like δ18O (5.8–4.3‰) values. These features suggest that the Ren Co ophiolite is typical of mid-ocean ridge-type ophiolite that is identified for the first time in the Bangong–Nujiang suture zone. We argue that the Ren Co ophiolite is the relic of a fast-spreading ridge that occurred in the main oceanic basin of the Bangong–Nujiang segment of Meso-Tethys. Here the Meso-Tethyan orogeny involves a continuous history of oceanic subduction, accretion, and continental assembly from the Early Jurassic to Early Cretaceous.
Onset of slip partitioning under oblique convergence within scaled physical experiments
Authors: Cooke Michele L. , Toeneboehn Kevin , Hatch Jennifer L. 
Published: March 2020

Abstract
Oblique convergent margins host slip-partitioned faults with simultaneously active strike-slip and reverse faults. Such systems defy energetic considerations that a single oblique-slip fault accommodates deformation more efficiently than multiple faults. To investigate the development of slip partitioning, we record deformation throughout scaled experiments of wet kaolin over a low-convergence (&lt;30°), obliquely slipping basal dislocation. The presence of a precut vertical weakness in the wet kaolin impacts the morphology of faults but is not required for slip partitioning. The experiments reveal three styles of slip partitioning development delineated by the order of faulting and the extent of slip partitioning. Low-convergence angle experiments (5°) produce strike-slip faults prior to reverse faults. In moderate-convergence experiments (10°–25°), the reverse fault forms prior to the strike-slip fault. Strike-slip faults develop either along existing weaknesses (precut or previous reverse-slip faults) or through the coalescence of new echelon cracks. The third style of local slip partitioning along two simultaneously active dipping faults is transient while global slip partitioning persists. The development of two active fault surfaces arises from changes in off-fault strain pattern after development of the first fault. With early strike-slip faults, off-fault contraction accumulates to produce a new reverse fault. Systems with early lobate reverse faults accommodate limited strike-slip and produce extension in the hanging wall, thereby promoting strike-slip faulting. The observation of persistent slip partitioning under a wide range of experimental conditions demonstrates why such systems are frequently observed in oblique convergence crustal margins around the world.
Evaluation of a complex integrated, cross-sectoral psycho-oncological care program (isPO): a mixed-methods study protocol
Authors: Jenniches Imke , Lemmen Clarissa , Cwik Jan Christopher , Kusch Michael , Labouvie Hildegard , Scholten Nadine , Gerlach Alexander , Stock Stephanie , Samel Christina , Hagemeier Anna , Hellmich Martin , Haas Peter , Hallek Michael , Pfaff Holger , Dresen Antje 
Published: March 2020

IntroductionInternational standards of care require the complete integration of psycho-oncological care into biomedical cancer treatment. The structured integrated, cross-sectoral psycho-oncological programme ‘isPO’ is aiming to ensure a provision of care in inpatient and outpatient settings according to a stepped-care approach. Up to now, psycho-oncological care is missing regulated and standardised processes to demonstrate the effectiveness. This study protocol describes the process and outcome evaluation that is conducted, along with the isPO study. The programme evaluation is aiming to proof effectiveness, explain potential discrepancies between expected and observed outcomes. Additionally, provide insight into the implementation process, as well as contextual factors that might promote or inhibit the dissemination and implementation of the stepped care programme will be gained. In addition to these measures, a cost–consequence analysis will provide further evidence aimed at integrating psycho-oncological care into primary healthcare.Methods and analysisThe evaluation concept is based on a tripartite strategy consisting of a prospective, formative and summative evaluation. To capture all determinants, a concurrent mixed-method design is applied comprising qualitative (interviews and focus groups) and quantitative (standardised questionnaires) surveys of patients and healthcare providers. In addition, analysis of the psycho-oncological care data (isPO care data) and statutory health insurance claims data will be conducted. Primary and secondary data will complement one another (data linkage) to obtain a more comprehensive picture of the effectiveness and implementation of the complex intervention within the isPO study.Ethics and disseminationThe study has been approved by the ethics committee of the Medical Faculty of the University of Cologne. For all collected data, the relevant national and European data protection regulations will be considered. All personal identifiers (eg, name, date of birth) will be pseudonymised. Dissemination strategies include annual reports as well as quality workshops for the organisations, the presentation of results in publications and on conferences, and public relations.Trial registration numberDRKS00015326; Pre-results.
Dissemination and implementation of thee-MCHHandbook, UNRWA’s newly released maternal and child health mobile application: a cross-sectional study
Authors: Nasir Seif , Goto Ryunosuke , Kitamura Akiko , Alafeef Sahar , Ballout Ghada , Hababeh Majed , Kiriya Junko , Seita Akihiro , Jimba Masamine 
Published: March 2020

ObjectivesIn April 2017, the United Nations Relief and Works Agency for Palestine Refugees in the Near East (UNRWA) released the electronicMaternal andChildHealth Handbook,thee-MCH Handbookapplication. One of the first mobile health (m-Health) interventions in a refugee setting, the application gives pregnant women and mothers access to educational information and health records on smartphones. This study investigated factors associated with the dissemination and implementation of m-Health in the refugee setting.Setting and participantsA cross-sectional study was conducted in 9 of 25 UNRWA health centres for Palestine refugees in Jordan. Self-administered questionnaires were distributed for 1 week to pregnant women and mothers with children aged 0–5 years.Outcome measuresThe outcomes were whether participants knew about, downloaded or used the application. Multiple regression analyses were conducted to determine factors associated with application download and usage.Results1042 participants were included in the analysis. 979 (95.5%) had a mobile phone and 862 (86.9%) had a smartphone. 499 (51.3%) knew about, 235 (23.8%) downloaded and 172 (17.4%) used the application. Having other mobile applications (OR 6.17, p<0.01), staff knowledge of the application (OR 11.82, p<0.01), using the internet as a source of medical information (OR 1.63, p=0.01) and having internet access at home (OR 1.46, p=0.05) were associated with application download. The age of the husband was associated with application usage (OR 1.04, p=0.11).ConclusionsThough m-Health may be a promising means of promoting health in refugees, multiple barriers may exist to its dissemination and implementation. Those who regularly use mobile applications and get medical information from the internet are potential targets of m-Health dissemination. For successful implementation of a m-Health intervention, health staff should have thorough knowledge of the application and users should have access to the internet. Husband-related factors may also play a role.
Animation-supported consent for urgent angiography and angioplasty: a service improvement initiative
Authors: Wald David S , Casey-Gillman Oliver , Comer Katrina , Mansell Josephine Sarah , Teoh Zhi H , Mouyis Kyriacos , Kelham Matthew , Chan Fiona , Ahmet Selda , Sayers Max , McCaughan Vincent , Polenio Nito 
Published: March 2020

ObjectivePatient understanding of angiography and angioplasty is often incomplete at the time of consent. Language barriers and time constraints are significant obstacles, particularly in the urgent setting. We introduced digital animations to support consent and assessed the effect on patient understanding.MethodsMulti-language animations explaining angiography and angioplasty (www.explainmyprocedure.com/heart) were introduced at nine district hospitals for patients with acute coronary syndrome before urgent transfer to a cardiac centre for their procedure. Reported understanding of the reason for transfer, the procedure, its benefits and risks in 100 consecutive patients were recorded before introduction of the animations into practice (no animation group) and in 100 consecutive patients after their introduction (animation group). Patient understanding in the two groups was compared.ResultsFollowing introduction, 83/100 patients reported they had watched the animation before inter-hospital transfer (3 declined and 14 were overlooked). The proportions of patients who understood the reason for transfer, the procedure, its benefits and risks in the no animation group were 58%, 38%, 25% and 7% and in the animation group, 85%, 81%, 73% and 61%, respectively. The relative improvement (ratio of proportions) was 1.5 (95% CI 1.2 to 1.8), 2.1 (1.6 to 2.8), 2.9 (2.0 to 4.2) and 8.7 (4.2 to 18.1), respectively (p<0.001 for all comparisons).ConclusionUse of animations explaining angiography and angioplasty is feasible before urgent inter-hospital transfer and was associated with substantial improvement in reported understanding of the procedure, its risks and its benefits. The approach is not limited to cardiology and has the potential to be applied to all specialties in medicine.
Impedance spectroscopy of (TlGaSe2)1−x(TlInSe2)x solid solutions in radio frequency range
Authors: Sardarli R. M. , Salmanov F. T. , Alieva N. A. , Abbasli R. M. 
Published: March 2020

The processes of charge transport on alternating current in [Formula: see text] solid solutions have been studied. It has been established that in weak alternating electric fields, there is a hopping mechanism of charge transfer over localized states in the vicinity of the Fermi level. A quantitative assessment of parameters was made in the framework of the effective medium theory and the Mott approximation. The use of impedance spectroscopy methods in [Formula: see text] solid solutions in the frequency range of 25–106 Hz, at temperatures of 180, 240 and 300 K charge transfer processes has been investigated. It was found that at 300 K in the low-frequency region, there are additional contributions to the conductivity, which, apparently, is associated with diffuse ion transfer near the boundary of the solid electrolyte and the electrode. Impedance locus curves, at low frequencies and at a temperature of 300 K, are characteristic of Warburg diffuse impedance.
Li-Fraumeni Exploration Consortium Data Coordinating Center: Building an Interactive Web-Based Resource for Collaborative International Cancer Epidemiology Research for a Rare Condition
Authors: Mai Phuong L. , Sand Sharon R. , Saha Neiladri , Oberti Mauricio , Dolafi Tom , DiGianni Lisa , Root Elizabeth J. , Kong Xianhua , Bremer Renee C. , Santiago Karina M. , Bojadzieva Jasmina , Barley Derek , Novokmet Ana , Ketchum Karen A. , Nguyen Ngoc , Jacob Shine , Nichols Kim E. , Kratz Christian P. , Schiffman Joshua D. , Evans D. Gareth , Achatz Maria Isabel , Strong Louise C. , Garber Judy E. , Ladwa Sweta A. , Malkin David , Weitzel Jeffrey N. 
Published: March 2020

Abstract

Background:
The success of multisite collaborative research relies on effective data collection, harmonization, and aggregation strategies. Data Coordination Centers (DCC) serve to facilitate the implementation of these strategies. The utility of a DCC can be particularly relevant for research on rare diseases where collaboration from multiple sites to amass large aggregate datasets is essential. However, approaches to building a DCC have been scarcely documented.

Methods:
The Li-Fraumeni Exploration (LiFE) Consortium's DCC was created using multiple open source packages, including LAM/G Application (Linux, Apache, MySQL, Grails), Extraction-Transformation-Loading (ETL) Pentaho Data Integration Tool, and the Saiku-Mondrian client. This document serves as a resource for building a rare disease DCC for multi-institutional collaborative research.

Results:
The primary scientific and technological objective to create an online central repository into which data from all participating sites could be deposited, harmonized, aggregated, disseminated, and analyzed was completed. The cohort now include 2,193 participants from six contributing sites, including 1,354 individuals from families with a pathogenic or likely variant in TP53. Data on cancer diagnoses are also available. Challenges and lessons learned are summarized.

Conclusions:
The methods leveraged mitigate challenges associated with successfully developing a DCC's technical infrastructure, data harmonization efforts, communications, and software development and applications.

Impact:
These methods can serve as a framework in establishing other collaborative research efforts. Data from the consortium will serve as a great resource for collaborative research to improve knowledge on, and the ability to care for, individuals and families with Li-Fraumeni syndrome.
Targeting NRAS-Mutant Cancers with the Selective STK19 Kinase Inhibitor Chelidonine
Authors: Qian Ling , Chen Kun , Wang Changhong , Chen Zhen , Meng Zhiqiang , Wang Peng 
Published: March 2020

Abstract

Purpose:
Oncogenic mutations in NRAS promote tumorigenesis. Although novel anti-NRAS inhibitors are urgently needed for the treatment of cancer, the protein is generally considered “undruggable” and no effective therapies have yet reached the clinic. STK19 kinase was recently reported to be a novel activator of NRAS and a potential therapeutic target for NRAS-mutant melanomas. Here, we describe a new pharmacologic inhibitor of STK19 kinase for the treatment of NRAS-mutant cancers.

Experimental Design:
The STK19 kinase inhibitor was identified from a natural compound library using a luminescent phosphorylation assay as the primary screen followed by verification with an in vitro kinase assay and immunoblotting of treated cell extracts. The antitumor potency of chelidonine was investigated in vitro and in vivo using a panel of NRAS-mutant and NRAS wild-type cancer cells.

Results:
Chelidonine was identified as a potent and selective inhibitor of STK19 kinase activity. In vitro, chelidonine treatment inhibited NRAS signaling, leading to reduced cell proliferation and induction of apoptosis in a panel of NRAS-mutant cancer cell lines, including melanoma, liver, lung, and gastric cancer. In vivo, chelidonine suppressed the growth of NRAS-driven tumor cells in nude mice while exhibiting minimal toxicity.

Conclusions:
Chelidonine suppresses NRAS-mutant cancer cell growth and could have utility as a new treatment for such malignancies.
The Impact of Molecular Subtype on Efficacy of Chemotherapy and Checkpoint Inhibition in Advanced Gastric Cancer
Authors: Kubota Yohei , Kawazoe Akihito , Sasaki Akinori , Mishima Saori , Sawada Kentaro , Nakamura Yoshiaki , Kotani Daisuke , Kuboki Yasutoshi , Taniguchi Hiroya , Kojima Takashi , Doi Toshihiko , Yoshino Takayuki , Ishii Genichiro , Kuwata Takeshi , Shitara Kohei 
Published: March 2020

Abstract

Purpose:
We evaluated the association between molecular subtypes of advanced gastric cancer (AGC) and the efficacy of standard chemotherapy or immune checkpoint inhibitors.

Experimental Design:
Patients with AGC who received systemic chemotherapy from October 2015 to July 2018 with available molecular features were analyzed. We investigated the efficacy of standard first- (fluoropyrimidine + platinum ± trastuzumab) and second-line (taxanes ± ramucirumab) chemotherapy, and subsequent anti–PD-1 therapy in patients with four molecular subtypes: MMR-D (mismatch repair deficient), EBV+, HER2+, and all negative.

Results:
410 patients were analyzed: MMR-D 5.9%, EBV+ 4.1%, HER2+ 13.7%, and all negative 76.3%. In 285 patients who received standard first-line chemotherapy, the median progression-free survival (PFS) times were 4.2, 6.0, 7.5, and 7.6 months and the objective response rates (ORR) were 31%, 62%, 60%, and 49% in MMR-D, EBV+, HER2+, and all-negative subtypes, respectively. Multivariate analysis showed shorter PFS in MMR-D versus all-negative patients [HR, 1.97; 95% CIs, 1.09–3.53; P = 0.022]. In second-line setting, there were no significant differences in efficacy. In 110 patients who received anti–PD-1 therapy, median PFS times were 13.0, 3.7, 1.6, and 1.9 months and the ORRs were 58%, 33%, 7%, and 13%, respectively. Twelve patients with MMR-D received subsequent anti–PD-1 therapy and showed longer PFS compared with that in 10 (83%) patients who received earlier-line chemotherapy.

Conclusions:
MMR-D might result in shorter PFS with first-line chemotherapy for AGC. Subsequent anti–PD-1 therapy achieved higher ORR and longer PFS than prior chemotherapy in most patients with MMR-D, supporting the earlier use of immune checkpoint inhibitors.