bluuebunny/crossref_metadata_2025_split huggingface dataset:
Population Pharmacokinetics and Model-Based Dosing Optimization of Teicoplanin in Pediatric Patients
Authors: Zhang Tao , Sun Dan , Shu Zuocheng , Duan Ziyun , Liu Yang , Du Qian , Zhang Ying , Dong Yuzhu , Wang Taotao , Hu Sasa , Cheng Hua , Dong Yalin 
Published: December 2020

Objectives: The pharmacokinetics (PK) of teicoplanin differs in children compared with adults. Our aim was to determine the PK of teicoplanin in an Asian pediatric population and to optimize dosage regimens.Methods: This was a retrospective PK study and all the data were collected from hospitalized children. We developed a population PK model using sparse data, and Monte Carlo simulation was used to assess the ability of standard teicoplanin regimen and other different dosage regimens. The optimal dosing regimens were defined as achieving the target trough concentration (Cmin) of 10 mg/L and pharmacokinetic/pharmacodynamic (PK/PD, [AUC24/MIC]) of 125 for moderate infection. For severe infection, the optimal dosing regimens were defined as achieving the target 15 mg/L and AUC24/MIC of 345.Results: 159 children were included and 1.5 samples/children on average were provided. Estimated clearance of teicoplanin was 0.694 L/h (0.784/L/h/70 kg) and volume of distribution was 1.39 L. Teicoplanin standard loading dose was adequate for moderate infection, while 13 mg/kg was needed for severer infection. With standard maintenance doses, both patients with moderate and severe infection failed to achieve the target Cmin. 12 and 16 mg/kg/day were required to achieve a Cmin ≥ 10 and 15 mg/L, respectively. However, standard maintenance dose was adequate to achieve AUC24/MIC ≥ 125 for moderate infection, and 12 mg/kg/day was needed to achieve AUC24/MIC ≥ 345 for severe infection. Lower weight and serum creatinine were associated with higher dose.Conclusion: Optimal doses based on the target Cmin were higher than that based on the PK/PD target. To achieve the Cmin and PK/PD targets simultaneously, a standard loading dose was adequate for moderate infection based on simulation, while dosing higher than standard doses were required in other situation. Further clinical studies with rich sampling from children is required to confirm our findings.
Cardiac Autonomic Dysfunction and Incidence of de novo Atrial Fibrillation: Heart Rate Variability vs. Heart Rate Complexity
Authors: Wessel Niels , Berg Karsten , Kraemer Jan F. , Gapelyuk Andrej , Rietsch Katrin , Hauser Tino , Kurths Jürgen , Wenzel Dave , Klein Norbert , Kolb Christof , Belke Roberto , Schirdewan Alexander , Kääb Stefan 
Published: December 2020

BackgroundThe REACT DX registry evaluates standard therapies to episodes of long-lasting atrial tachyarrhythmias and assesses the quality of sensing and stability of the lead and the implantable cardioverter-defibrillator (ICD) (BIOTRONIK Lumax VR-T DX and successors) over at least a 1-year follow-up period.ObjectiveTo study the association between the risk of de novo device-detected atrial fibrillation (AF), the autonomic perturbations before the onset of paroxysmal AF and a 7-days heart rate variability (7dHRV) 1 month after ICD implantation.MethodsThe registry consists of 234 patients implanted with an ICD, including 10 with de novo long-lasting atrial tachyarrhythmias with no prior history of AF. The patients were matched via the propensity-score methodology as well as for properties directly influencing the ECGs recorded using GE CardioMem CM 3000. Heart rate variability (HRV) analysis was performed using standard parameters from time- and frequency-domains, and from non-linear dynamics.ResultsNo linear HRV was associated with an increased risk of AF (p = n.s.). The only significant approach was derived from symbolic dynamics with the parameter “forbidden words” which distinguished both groups on all 7 days of measurements (p &lt; 0.05), thereby quantifying the heart rate complexity (HRC) as drastically lower in the de novo AF group.ConclusionCardiac autonomic dysfunction denoted by low HRC may be associated with higher AF incidence. For patients with mild to moderate heart failure, standard HRV parameters are not appropriate to quantify cardiac autonomic perturbations before the onset of AF. Further studies are needed to determine the individual risk for AF that would enable interventions to restore autonomic balance in the general population.
Clinical Outcomes by Albuminuria Status with Dulaglutide versus Insulin Glargine in Participants with Diabetes and CKD: AWARD-7 Exploratory Analysis
Authors: Tuttle Katherine R. , Rayner Brian , Lakshmanan Mark C. , Kwan Anita Y.M. , Konig Manige , Shurzinske Linda , Botros Fady T. 
Published: December 2020

Background
In the AWARD-7 trial of participants with type 2 diabetes (T2DM) and moderate-to-severe CKD, dulaglutide (DU) treatment slowed decline in eGFR compared with insulin glargine (IG). Treatment with doses of either DU or IG resulted in similar levels of glycemic control and BP. The aim of this analysis was to determine the risk of clinical event outcomes between treatment groups.

Methods
Participants with T2DM and CKD categories 3–4 were randomized (1:1:1) to 0.75 or 1.5 mg DU weekly or IG daily as basal therapy, with titrated insulin lispro, for 1 year. The time to occurrence of the composite outcome of ≥40% eGFR decline, ESKD, or death due to kidney disease was compared using a Cox proportional-hazards model.

Results
Patients treated with 1.5 mg DU weekly versus IG daily for 1 year had a lower risk of ≥40% eGFR decline or ESKD events in the overall study population (5% versus 11%; hazard ratio, 0.45; 95% CI, 0.20 to 0.97; P=0.04). Most events occurred in the subset of patients with macroalbuminuria, where risk of the composite outcome was substantially lower for 1.5 mg DU versus IG (7% versus 22%; hazard ratio, 0.25; 95% CI, 0.10 to 0.68; P=0.006). No deaths due to kidney disease occurred.

Conclusions
Treatment with 1.5 mg DU weekly was associated with a clinically relevant risk reduction of ≥40% eGFR decline or ESKD compared with IG daily, particularly in the macroalbuminuria subgroup of participants with T2DM and moderate-to-severe CKD.
ESTIMASI ERROR: ANCHORING-ADJUSTMENT DAN REAKSI INVESTOR
Authors: Praditha Riza 
Published: December 2020

This study aims to test the estimation error of future earnings made by investors and analyze the psychological factors heuristic (anchoring-adjustment) experienced. The subjects in this study were accounting and financial management students at STIE Tri Dharma Nusantara who were proxied as investors. The research design used was within-subject laboratory experiments. The analytical method uses the General Linear Model - Repeated Measurement. The results showed that investors experienced bias in estimating future earnings. Bias is indicated by the magnitude of the error of estimated earnings has a tendency that is close to its initial value. Investors overestimate future earnings when they obtain information with a positive initial value, while investors underestimate the performance of future earnings if they obtain earnings information with a negative initial value. This means that investors experience anchoring-adjustment heuristics and underreaction behavior towards the earnings information presented.

Tujuan penelitian ini adalah untuk menguji kesalahan estimasi laba masa depan yang dilakukan investor serta menganalisis faktor psikologi heuristik (anchoring-adjustment) yang dialami. Subjek dalam penelitian ini adalah mahasiswa akuntansi dan manajemen keuangan pada STIE Tri Dharma Nusantara yang diproksikan sebagai investor. Desain penelitian yang digunakan adalah eksperimen laboratorium within-subject. Metode analisis menggunakan General Linear Model – Repeated Measurement. Hasil penelitian menunjukkan bahwa investor mengalami bias dalam mengestimasi laba masa depan. Bias yang ditunjukkan dengan besaran kesalahan estimasi laba memiliki kecenderungan yang mendekati nilai awalnya. Investor megestimasi laba masa depan lebih tinggi (overestimate) ketika memperoleh informasi dengan nilai awal positif, sebaliknya investor underestimate terhadap kinerja laba masa depan jika memperoleh informasi laba dengan nilai awal negatif. Hal ini berarti bahwa investor mengalami heuristik anchoring-adjustment dan berperilaku underraction terhadap informasi laba yang disajikan.
ANALISIS PELAKSANAAN PELAYANAN ANC TERPADU DI PUSKESMAS TEMBILAHAN HULU
Authors: Harianis Sandra , Sari Mia Rita , Sari Dewi Erlina Asrita , Madinah Madinah 
Published: December 2020

Abstract
The health of pregnant women is still a national health problem. Ante Natal Care (ANC) services integrated with 10 standards can improve maternal and fetal health. However, in recent years complications of pregnancy and childbirth have increased which should be identified early with the right ANC.
This study aims to explore the implementation of ANC 10 standards and obstacles in their implementation. This study uses a qualitative design with a phenomenological approach. The study began with qualitative data collection through focus group discussion (FGD) and in-depth interviews and quantitative data collection through filling out questionnaires in October-November 2018 in the working area of ​​the Upper Tembilahan Health Center. The sample of this study was all midwives at the Tembilahan Hulu health center and pregnant women were randomly taken as many as 138 people.
The findings of this study note 35 out of 138 (25.4%) pregnant women received standard ANC 10 services in full. Weigh BB and measure TB (86.23%), measure blood pressure (100%), nutritional status (88.41%), measure TFU (85.51%), value of fetal presentation (81.88%), srining T (81.16%), Fe tablets (71.01%), labor checks (81.88%), case management (82.61%), and speech meetings (69.57%). The obstacle of midwives is inadequate facilities and infrastructure and the weak skills of midwives in implementing standards.
The need for monitoring and evaluation of KIA program holders and guidance and training for integrated ANC servants for all midwives
KARAKTERISTIK IBU MEMBERIKAN MAKANAN PENDAMPING ASI (MP-ASI) PADA BAYI USIA 0 – 6 BULAN DI WILAYAH KERJA PUSKESMAS HARAPAN RAYA PEKANBARU TAHUN 2018
Authors: Irianti Berliana , Sari Eka Purnama 
Published: December 2020

Complementary food breastfeeding are foods that contain nutrients, given to children age 6 – 24 months to fulfill their nutritional needs Complementary food breastfeeding precisely influenced by the behavior of mothers who have babies. But there are still many mothers giving complementary foods breastfeeding for less than 6 months, which can cause a negative impact for health of the baby such as diarrhoea and even death can result in babies. This research aims to know the characteristics of mothers in giving Complementary Food breastfeeding for less than 6 months. This research is quantitative descriptive design with population of mothers that have babies aged 7-12 months amounted to 2,494 people, with 96 samples taken with quota sampling, this research was conducted in the working area of Harapan Raya Health Centre Pekanbaru on March – April 2018, data was collection is done by filling the questionnaire. The research results obtained 91 people (94.79%) respondents aged 20 – 35 years, 56 people (58.33%) respondents primigravida, 76 people (79.18%) respondents have High School, 71 people (73.96%) respondents it does not work , 57 people (59.37%) respondents knowledgeable enough. Based on the results obtained is expected that health worker can increase counselling to mothers about breastfeeding and how to overcome the problems that occur while breastfeeding so giving exclusive breasfeeding can be implemented properly.
FAKTOR YANG BERHUBUNGAN DENGAN KELENGKAPAN IMUNISASI DASAR DI PUSKESMAS RAWAT INAP SIMPANG TIGA
Authors: ISTAWATI RIKA , Yanti Penti Dora , Anggraini Vidya 
Published: December 2020

ABSTRACT
Immunization is one form of health intervention that is very effective in efforts to reduce infant and under-five mortality. Based on the Results of Monthly Reports on Routine Immunization of Pekanbaru City Health Center Infants, the Simpang Tiga Inpatient Health Center has the lowest immunization coverage from 20 puskesmas. This type of research is quantitative analytic with cross sectional approach. The population in this study were mothers who had infants aged 9 months to 2 years in the Simpang Tiga Inpatient Health Center with a sample of 71 respondents. In this study the technique used was accidental sampling. The instrument used in this study was a questionnaire. From the results of the study it was found that the variables related to the completeness of basic immunization were the level of knowledge of the mother (pvalue = 0,000). Whereas the variables not related to the completeness of basic immunization are the mother's education level (pvalue = 0.321), and family support (pvalue = 0.619)
PERSEPSI IBU HAMIL TERHADAP PENULARAN HIV KE BAYI DI WILAYAH KERJA PUSKESMAS PERAWANG KABUPATEN SIAK
Authors: Yuningsih Silvia Anita , Afriyanti Eti 
Published: December 2020

ABSTRACT

HIV/AIDS case in Indonesia occupied the 5th position from Asian countries, based on statistical data of HIV prevalence in pregnancy mother is projected to increase from 0,38 % (2012) to 0,49 % (2016) and the number of pregnancy mother get positive HIV who need PPIA services will be increase from 13.189 in 2012 to 16.191 in 2016. The purpose of this study was to find the relationship between age, education, occupation and knowledge with the perception of pregnant women on HIV transmission to infants in Perawang Village. This research is quantitative with analytic design cross sectional approach. Samples in this study of 78 respondets accidental sampling. Data analysis univariate and bivariate. Based on statistic test showed that there were relationship between age, education, and knowledge with perception of pregnancy mother against transmission of HIV to infants in sub district Perawang, Perawang Community Health Center, Siak with p value < α 0,05. (Age <0.014, Education <0.018, and Knowledge <0.026). The results of this study also serve as information for pregnant women to cope with HIV transmission from mother to baby and is expected for health workers to further improve the provision of information by disseminating around HIV / AIDS material.

Keywords : Age, education, occupation, knowlodge, HIV/AIDS
EVALUASI DAN IMPLEMENTASI SISTEM SURVEILANS CAMPAK DI KABUPATEN MAGELANG PROVINSI JAWA TENGAH
Authors: Hayu Riska Epina 
Published: December 2020

Kegiatan surveilans terdapat beberapa penyakit menular tertentu yang potensial menimbulkan wabah dan telah mengembangkan sistem surveilans sendiri serta menjadi sub sistem dari surveilans pencegahan penyakit secara umum yaitu penyakit Demam Berdarah Dengue (DBD), penyakit malaria, penyakit-penyakit yang dapat dicegah dengan imunisasi (PD31). Penyakit campak masih menjadi masalah kesehatan, mengingat masih adanya kasus dan wabah campak di beberapa daerah di Indonesia. Campak adalah penyakit infaksi virus yang merupakan penyebab kematian pada anak di Negara-negara berkembang termasuk Indonesia. Kasus terdiagnosa campak klinis tahun 2011 dilaporkan sebanyak 398 kasus, dan sebagian besar terjadi pada anak umur <15 tahun yaitu sebanyak 321 kasus atau 80,6%. Penelitian ini adalah penelitian deskriptif. Aspek yang dievaluasi adalah input, proses dan output. Pengumpulan data primer dilakukan dengan observasi dan wawancara langsung dengan petugas imunisasi di Puskesmas. Data sekunder diperoleh berdasarkan pencatatan dan pelaporan di Dinas Kesehatan Kabupaten. Kemudian dilakukan intervensi sesuai dengan masalah yang ditemukan. Peningkatan kelengkapan laporam setelah dilakukan intervensi menjadi 100%. Pada analsis dan interpretasi data puskesmas yang mengatakan mengalami hambatan dan masalah adalah 22 (75.86%) puskesmas. Penyebarluasan informasi data campak secara lintas instansi sudah berjalan cukup baik namun belum optimal. Kelemahan petugas surveilans campak terdapat pada pada pengolahan, penyajian, analisis dan interpretasi data sebelum dilakukannya intervensi. Beberapa mengeluhkan bahwa mereka tidak memahami dengan baik cara pengolahan, penyajian, analisis dan interpretasi data dengan baik dan beberapa dari mereka merupakan petugas baru yang belum mendapatkan pelatihan tentang surveilans campak.
EFEKTIVITAS MEDIA BERGAMBAR DAN PENYULUHAN METODE CERAMAH TANYA JAWAB (CTJ) TERHADAP PERILAKU MAKAN, AKTIVITAS FISIK DAN POLA TIDUR REMAJA UNDERWEIGHT TAHUN 2019
Authors: Sari Ecy kartika , Zahtamal Zahtamal , Nurlisis Nurlisis , Rany Novita , Septiani Winda 
Published: December 2020

Underweight or lack of weight is state of being caused by the lack of energy intake compared with the amount og eergy expended. A lack of energy intake or consumption of essential nutrients needed by the body can be lowered activity was done by teenager. The result of the preliminary survey they that were undertaken in the senior high school 13 and 1 At Pekabaru, would be in the low teens 33 should be run as soon as many as 20 a teenager slipped to only their second underweight. The study aims to know about the effectiveness of media pictorial and counseling with the methods talk question and answer to behavior eat, physical activity dan sleep patterns undeweight teenagers in 13 and 1 Senior High School At Pekanbaru City. the kind of research used is (quasi experiment) with nonequivalent group pre-test post-test design. The Research is done at the July 2019. The population in this research is the entire fourth grade VII, VIII and IX. Use sampling tehniques is non random sampling. Instrumen on the study using by questionnaires, and data anlysis be done in univariat and bivariat. The results of study by test wicolxon and Mann Whitney test, and showed there were differences in the effectiveness of the pictorial media and counseling on question and answer lectures on changes in eating behavior, physical activity and sleep patterns of underweight adolescents in 13 and 1 Senior High School At Pekanbaru City. Schools should provide adequate outreach facilities such as picture books and powerpoints. So that counseling can be carried out smoothly and without obstacles.

References : 49 References (2010-2016)
KUALITAS AIR SUNGAI SAGO KECAMATAN SENAPELAN KOTA PEKANBARU TAHUN 2016
Authors: Fitri Jufenti Ade 
Published: December 2020

ABSTRAK
Sungai Sago yang merupakan anak sungai Siak yang telah mendapat tekanan-tekanan lingkungan akibat dari pemanfaatan lahan serta aktivitas-aktivitas manusia berupa permukiman, pasar, perkantoran, rumah sakit dan industri. Tekanan lingkungan tersebut diindikasikan telah menyebabkan terjadinya penurunan kualitas air Sungai Sago.
Tujuan Umum penelitian ini yaitu untuk Mengetahui Kualitas Air sungai Sago Kecamatan Senapelan Kota Pekanbaru 2016 dan faktor yang mempengaruhi kualitas air Sungai Sago Kecamatan Senapelan Kota Pekanbaru.
Penelitian ini bersifat Deskriptif Kuantitatif dengan desain penelitian Non Standar, guna mengetahui kualitas air sungai berdasarkan indikator Kualitas Air. Sampel yang diambil yaitu dari 3 titik, Stasiun I di Hulu lokasi jl. Cut Nyak Dien gg. Jambu Air, Stasiun II di Tengah lokasi jl. Juanda, Stasiun III di Hilir jl. Pelita Pantai.
Hasil penelitian ini yaitu menjelaskan bahwa Kualitas Air Sungai Sago pada Stasiun I di Hulu adalah termasuk kategori sedang (Medium) dengan angka WQI (Water Quality Index) pada pagi hari yaitu 66.09 dan sore hari 65.33. Stasiun II di Tengah adalah termasuk kategori sedang (Medium) dengan angka WQI (Water Quality Index) pada pagi hari yaitu 61.05 dan sore hari 56.34. Stasiun III di Hilir adalah termasuk kategori sedang dengan angka WQI (Water Quality Index) pada pagi hari yaitu 65.45 dan sore hari 57.88.
Kesimpulan dalam penelitian ini adalah Aktifitas Masyarakat Daerah Aliran Sungai Sago akan mempengaruhi kualitas air Sungai Sago .
Saran dalam penelitian ini adalah Signifikansi Sosial Diharapkan penerapan Perda Kota Pekanbaru tentang Sumur Resapan. Signifikansi Ilmiah Hasil penelitian sejenis agar dilakukan sampling berulang-ulang berdasarkan waktu yang berbeda.

Kata Kunci : Kualitas air, Sungai, Daerah Aliran Sungai (DAS)
Non-equilibrium engineering of chemically grown SiO2/Si by UV nanosecond pulsed laser annealing from the viewpoint of bias temperature instability sources
Authors: Tabata Toshiyuki , Inoue Kenji , Yoshida Yukifumi , Takahashi Hiroaki 
Published: December 2020

Abstract
The impacts of high-temperature UV nanosecond pulsed laser annealing (LA) on a chemically grown SiO2/Si system are systematically investigated as a function of the number of irradiated pulses. A progressive transition is observed for both the tetrahedral SiO4 network and the SiO2/Si interface, being assumed to play an essential role in controlling bulk SiO2 traps and interface states. The presented results open the perspective to improve bias temperature instability of low thermal budget gate stacks by UV ns pulsed LA, particularly in emerging 3D integrations.
Crystallite distribution analysis based on hydrogen content in thin-film nanocrystalline silicon solar cells by atom probe tomography
Authors: Shimizu Yasuo , Sai Hitoshi , Matsui Takuya , Taki Kenji , Hashiguchi Taiki , Katayama Hirotaka , Matsumoto Mitsuhiro , Terakawa Akira , Inoue Koji , Nagai Yasuyoshi 
Published: December 2020

Abstract
The three-dimensional (3D) distribution of nanosized silicon (Si) crystallites within a hydrogenated nanocrystalline Si (nc-Si:H) material is examined by laser-assisted atom probe tomography (APT). The amorphous and crystalline phases in nc-Si:H are distinguished by obtaining the 3D density distribution of H atoms, because the former contains a high H density. The H content in the amorphous phase is estimated to be approximately 15 at% by APT, which is consistent with that obtained by infrared spectroscopy. Thus, the 3D analysis of H distribution via APT is a powerful method to visualize the real shape of nanosized crystallites within nc-Si:H materials.
An opto-thermal study of high brightness 280 nm emission AlGaN micropixel light-emitting diode arrays
Authors: Floyd Richard , Gaevski Mikhail , Alam Md Didarul , Islam Samia , Hussain Kamal , Mamun Abdullah , Mollah Shahab , Simin Grigory , Chandrashekhar MVS , Khan Asif 
Published: December 2020

Abstract
We present a study of the light output power and the thermal impedance of 281 nm emission AlGaN based micropixel LEDs. A modular interconnected micropixel array design is presented which enables dense packing with area and power scalability. We study 5–15 μm diameter stand-alone devices and parallel-connected micropixel arrays with 5 μm interpixel gaps. A standalone 5 μm pixel emits 291 W cm−2 at 10.2 kA cm−2 DC-drive. A power as high as 23 mW (361 W cm−2) was measured at a pulsed-pump current of 800 mA (∼15 kA cm−2) for an interconnected array. These are the smallest and brightest DUV LEDs to date.
Política y retórica de la pluriculturalidad en el Ecuador.
Authors: Posern-Zieliński Aleksander 
Published: December 2020

Short Description:
The article presents a portion of observations made in 1990’s in Ecuador by the team of researchers lead by Posern-Zieliński. The research focused on the emergence of new identities in Ecuador, with particular interest in the indigenous groups’ identities. The article introduces the demographics of Ecuador, and a short history of political projects related with multiculturalism.