bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the Effect of Supplied Flow Rate to the Performance of a Tilting-Pad Journal Bearing—Static Load and Dynamic Force Measurements
Authors: San Andrés Luis , Jani Hardik , Kaizar Hussain , Thorat Manish 
Published: October 2020

Abstract
Rotating machinery relies on engineered tilting-pad journal bearings (TPJB) to provide static load support with minimal drag power losses, safe pad temperatures, and ensuring a rotor-dynamic stable rotor operation. End users focus on reducing the supplied oil flow rate into a bearing to both lower operational costs and to increase drive power efficiency. This paper presents measurements of the steady-state and dynamic forced performance of a TPJB whilst focusing on the influence of supplied oil flow rate, below and above a nominal condition (50% and 150%). The test bearing has five pads, slenderness ratio L/D = 0.4, spherical pivots with pad offset = 50%, and a preload –0.40, with a clearance to radius ratio (Cr/R) ≈ 0.001 at room temperature. The bearing is installed under a load-between-pads (LBP) orientation and has a flooded housing with end seals. The test conditions include operation at various shaft surface speeds (32 m/s–85 m/s) and specific static loads from 0.17 MPa to 2.1 MPa. A turbine oil lubricates the bearing with a speed-dependent flow rate delivered at a constant supply temperature. Measurements obtained at a steady thermal equilibrium include the journal static eccentricity and attitude angle, the oil exit temperature rise, and the pads' subsurface temperatures at various locations, circumferential and axial. The rig includes measurement of the drive torque and shaft speed to produce the bearing drag power loss. Dynamic force coefficients include stiffness, damping, and virtual-mass coefficients. As expected, the drag power and the lubricant temperature rise depend mainly on shaft speed rather than on applied load. A reduction in oil flow rate to 50% of its nominal magnitude causes a modest increase in journal eccentricity, a 15% reduction in drag power loss, a moderate raise (6 °C) in pads' subsurface temperatures, a slight increase (up to 6%) in the direct stiffnesses, and a decrease (up to 7%) in direct damping coefficients. Conversely, a 1.5 times increase in oil flow rate causes a slight increase (up to 9%) in drag power loss, a moderate reduction of pads' temperatures (up to 3 °C), a maximum 5% reduction in direct stiffnesses, and a maximum 10% increase in direct damping. The paper also presents comparisons of the test results against predictions from a thermo-elastohydrodynamic (TEHD) lubrication model. In conclusion, a 50% reduced oil flow rate only causes a slight degradation in the test bearing static and dynamic force performance and does not make the bearing operation unsafe for tests with surface speed up to 74 m/s. As an important corollary, the measured bearing drag power differs from the conventional estimate derived from the product of the supplied flow rate, the lubricant-specific heat, and the oil exit temperature rise.
Bioengineered human blood vessels
Authors: Niklason Laura E. , Lawson Jeffrey H. 
Published: October 2020

Evolution of bioengineered blood vessels
Biotechnology approaches to repair and replace arteries have been under development for more than a century. Early synthetic approaches used rubber-based replacements, which then evolved into the use of polymer fabrics and, more recently, into biological approaches that permit the growth of blood vessels in the laboratory. Niklason and Lawson review the scientific and technological advances that allow the regeneration of a patient's own blood vessels. The authors discuss how blood vessel cells, when combined with suitable substrates for tissue growth under conditions that mimic human physiology, can produce functional bioengineered arteries. These biological approaches pave the way to advancing how vascular disease is managed and treated in the future.

Science
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eaaw8682
Factors associated with undiagnosed type 2 diabetes in Germany: results from German Health Interview and Examination Survey for Adults 2008–2011
Authors: Du Yong , Baumert Jens , Paprott Rebecca , Teti Andrea , Heidemann Christin , Scheidt-Nave Christa 
Published: October 2020

IntroductionTo identify characteristics of people with undiagnosed type 2 diabetes (T2D) among adults in Germany.Research design and methodsThe study population comprised participants aged 40–79 years of the German Health Interview and Examination Survey for Adults 2008–2011. Glycemic status was categorized as undiagnosed T2D (glycated hemoglobin A1c (HbA1c) ≥48 mmol/mol (6.5%), n=135), diagnosed T2D (n=518) and normoglycemia (HbA1c<48 mmol/mol (6.5%), n=4451). Multinomial logistic regression models including glycemic status as the outcome variable and sociodemographic characteristics, living alone, diabetes risk factors and healthcare services utilization as independent variables were used to identify factors associated with undiagnosed T2D compared with normoglycemia and diagnosed T2D. Odds ratios (ORs) and 95% confidence intervals (CIs) are reported as measure of association between the outcome and independent variables.ResultsThe prevalence of undiagnosed T2D was 2.9% (95% CI 2.2% to 3.9%) at an overall prevalence of 12.3% (11.0% to 13.6%) of persons with undiagnosed or diagnosed T2D. In multivariable analyses, factors associated with undiagnosed as well as diagnosed T2D in comparison to normoglycemia were older age (OR 1.04, 95% CI 1.01 to 1.06, per year, for undiagnosed T2D; OR 1.08, 1.07 to 1.10 for diagnosed T2D), male sex (3.33, 2.18 to 5.07; 1.91, 1.43 to 2.56), obesity (3.47, 2.17 to 5.56; 2.68, 2.04 to 3.52), hypertension (1.66, 1.09 to 2.53; 2.04, 1.42 to 2.95) and parental history of diabetes (2.04, 1.24 to 3.35; 3.16, 2.30 to 4.34). Variables independently associated with undiagnosed T2D but not diagnosed T2D included living alone (2.20; 1.36 to 3.56) and not seeing a doctor within the past year (2.57; 1.34 to 4.93). People with undiagnosed T2D were further younger and more likely to be male sex and reside in the western part of Germany than people with diagnosed T2D.ConclusionApart from major known risk factors of diabetes, characteristics specific to undiagnosed diabetes among adults in Germany will serve to inform the national education and communication strategy on diabetes mellitus in Germany.
Clinical outcomes of pre-loaded ultra-thin DSAEK and pre-loaded DMEK
Authors: Romano Vito , Pagano Luca , Gadhvi Kunal A , Coco Giulia , Titley Mitchell , Fenech Matthew Thomas , Ferrari Stefano , Levis Hannah J , Parekh Mohit , Kaye Stephen 
Published: October 2020

ObjectiveTo compare clinical outcomes and complications between pre-loaded ultra-thin Descemet stripping automated endothelialkeratoplasty (pl-UT-DSAEK) and pre-loaded Descemet membrane endothelial keratoplasty (pl-DMEK).Methods and analysisComparative study in patients with endothelial dysfunction associated with Fuchs endothelial corneal dystrophy and pseudophakic bullous keratopathy who underwent pl-UT-DSAEK or pl-DMEK transplants. For both groups, the tissues were pre-loaded at the Fondazione Banca degli Occhi del Veneto (Venice, Italy) and shipped to The Royal Liverpool University Hospital (Liverpool, UK). Best corrected visual acuity (BCVA) and re-bubbling rates were the main outcome measures.Results56 eyes of 56 patients were included. 31 received pl-UT-DSAEK and 25 received pl-DMEK. At 12 months, BCVA (LogMAR) was significantly better for pl-DMEK (0.17±0.20 LogMAR) compared with pl-UT-DSAEK (0.37±0.37 LogMAR, p<0.01). The percentage of people that achieved ≥20/30 was significantly higher in the pl-DMEK group. The rate of re-bubbling, however, was significantly higher for pl-DMEK (44.0%) than for Pl-UT-DSAEK (12.9%), p<0.01.ConclusionPl-DMEK offers better BCVA than pl-UT-DSAEK. The higher re-bubbling rate associated with pre-loaded DMEK is of concern.
Bardoxolone Methyl Displays Detrimental Effects on Endothelial Bioenergetics, Suppresses Endothelial ET-1 Release, and Increases Endothelial Permeability in Human Microvascular Endothelium
Authors: Szczesny-Malysiak Ewa , Stojak Marta , Campagna Roberto , Grosicki Marek , Jamrozik Marek , Kaczara Patrycja , Chlopicki Stefan 
Published: October 2020

Nrf2 is a master regulator of antioxidant cellular defence, and agents activating the Nrf2 pathway have been tested in various diseases. However, unexpected side effects of cardiovascular nature reported for bardoxolone methyl in patients with type 2 diabetes mellitus and stage 4 chronic kidney disease (the BEACON trial) still have not been fully explained. Here, we aimed to characterize the effects of bardoxolone methyl compared with other Nrf2 activators—dimethyl fumarate and L-sulforaphane—on human microvascular endothelium. Endothelial toxicity, bioenergetics, mitochondrial membrane potential, endothelin-1 (ET-1) release, endothelial permeability, Nrf2 expression, and ROS production were assessed in human microvascular endothelial cells (HMEC-1) incubated for 3 and 24 hours with 100 nM–5 μM of either bardoxolone methyl, dimethyl fumarate, or L-sulforaphane. Three-hour incubation with bardoxolone methyl (100 nM–5 μM), although not toxic to endothelial cells, significantly affected endothelial bioenergetics by decreasing mitochondrial membrane potential (

concentrations
≥
3

μ
M

), decreasing spare respiratory capacity (

concentrations
≥
1

μ
M

), and increasing proton leak (

concentrations
≥
500

nM

), while dimethyl fumarate and L-sulforaphane did not exert such actions. Bardoxolone methyl at

concentrations
≥
3

μ
M

also decreased cellular viability and induced necrosis and apoptosis in the endothelium upon 24-hour incubation. In turn, endothelin-1 decreased permeability in endothelial cells in picomolar range, while bardoxolone methyl decreased ET-1 release and increased endothelial permeability even after short-term (3 hours) incubation. In conclusion, despite that all three Nrf2 activators exerted some beneficial effects on the endothelium, as evidenced by a decrease in ROS production, bardoxolone methyl, the most potent Nrf2 activator among the tested compounds, displayed a distinct endothelial profile of activity comprising detrimental effects on mitochondria and cellular viability and suppression of endothelial ET-1 release possibly interfering with ET-1–dependent local regulation of endothelial permeability.
The Functional Landscape of Patient-Derived RNF43 Mutations Predicts Sensitivity to Wnt Inhibition
Authors: Yu Jia , Yusoff Permeen A. Mohamed , Woutersen Daniëlle T.J. , Goh Pamela , Harmston Nathan , Smits Ron , Epstein David M. , Virshup David M. , Madan Babita 
Published: October 2020

AbstractA subset of Wnt-addicted cancers are sensitive to targeted therapies that block Wnt secretion or receptor engagement. RNF43 loss-of-function (LOF) mutations that increase cell surface Wnt receptor abundance cause sensitivity to Wnt inhibitors. However, it is not clear which of the clinically identified RNF43 mutations affect its function in vivo. We assayed 119 missense and 45 truncating RNF43 mutations found in human cancers using a combination of cell-based reporter assays, genome editing, flow cytometry, and immunofluorescence microscopy. Five common germline variants of RNF43 exhibited wild-type activity. Cancer-associated missense mutations in the RING ubiquitin ligase domain and a subset of mutations in the extracellular domain hyperactivate Wnt/β-catenin signaling through formation of inactive dimers with endogenous RNF43 or ZNRF3. RNF43 C-terminal truncation mutants, including the common G659fs mutant are LOF specifically when endogenous mutations are examined, unlike their behavior in transient transfection assays. Patient-derived xenografts and cell lines with C-terminal truncations showed increased cell surface Frizzled and Wnt/β-catenin signaling and were responsive to porcupine (PORCN) inhibition in vivo, providing clear evidence of RNF43 impairment. Our study provides potential guidelines for patient assignment, as virtually all RNF43 nonsense and frameshift mutations, including those in the C-terminal domain and a large number of patient-associated missense mutations in the RING domain and N-terminal region compromise its activity, and therefore predict response to upstream Wnt inhibitors in cancers without microsatellite instability. This study expands the landscape of actionable RNF43 mutations, extending the benefit of these therapies to additional patients.Significance:Systematic examination of patient-derived RNF43 mutations identifies rules to guide patient selection, including that truncation or point mutations in well-defined functional domains sensitize cancers to PORCN inhibitors.
Two Notes on the Career of Aeschylus
Authors: Brown Andrew 
Published: October 2020

Abstract
The first part of this article seeks to reinforce the case made by S. Scullion that the fabled contest between Aeschylus, Pratinas and Choerilus in about 499, which was supposed to be the occasion of Aeschylus’s first dramatic production, is an invention and that ancient scholars did not possess detailed archival information (if any information at all) concerning the early years of his career. The second part argues that, while the tradition that the poet died at Gela in Sicily is very probably true, he almost certainly did not intend to settle there permanently and there is no reason to believe that he left Athens soon after presenting the Oresteia in 458. It then considers Aeschylus’s possible route from Athens to Sicily and argues that he could not easily have made the journey before the Athenians seized Naupactus, probably in 456.
Introduction to the Tafel v-bis Dataset: Death Duty Summary Information for The Netherlands, 1921
Authors: de Vicq A. , Peeters R. 
Published: October 2020

Abstract
This article introduces a newly constructed dataset (i.e. the Tafel v-bis Dataset) containing summary information for all Dutch citizens who died in 1921 and were subject to inheritance taxation. This dataset provides personal and socio-economic information on 24,263 individuals, including their total wealth, age, profession, residence and marital status at their time of death. Consequently, this dataset can be useful for researchers stemming from various academic disciplines. The article first discusses the range of possible uses of the dataset. Then the authors explain how they constructed the dataset and provide the necessary criticism regarding the underlying source material. The dataset is available via the Utrecht University data platform, yoda.
Trajectories and predictors of anxiety symptoms during pregnancy in an Australian sample
Authors: Viswasam Kirupamani , Berle David , Starcevic Vladan 
Published: October 2020

Background: There is a growing realisation that anxiety symptoms and disorders during pregnancy are associated with various negative outcomes. The aims of this study were to identify latent classes of anxiety symptom trajectories during pregnancy, compare anxiety levels between pregnancy trimesters and ascertain the predictors of anxiety symptom trajectories. Methods: Two hundred pregnant women in their first trimester who attended obstetric clinics at the local hospital were recruited. Three self-report questionnaires assessing anxiety levels were administered at three time points during pregnancy. Latent class growth analysis was used to identify anxiety symptom trajectories, and logistic regression analysis was performed to ascertain the predictors of latent class membership. Results: Data for analyses were available for 188 women. Two anxiety symptom trajectories were identified: a ‘high-anxiety’ trajectory (13.3% of participating women) and ‘low-anxiety’ trajectory (86.7%). This finding was consistent across all the anxiety measures used in the study. Overall, anxiety levels gradually decreased during pregnancy, with a significant decrease between the first and second trimesters on some measures. Past mental disorders and significant stressors in the preceding 6 months predicted membership in the ‘high-anxiety’ trajectory group. Conclusions: These findings support an early assessment of anxiety in pregnant women. If untreated, a high level of anxiety in the first trimester is likely to persist throughout pregnancy, although it may decrease somewhat. An early recognition of pathological anxiety during pregnancy allows its timely treatment and prevention of unfavourable outcomes.
A qualitative study on the use of mobile-based intervention for perinatal depression among perinatal mothers in rural Bihar, India
Authors: Seshu Uttara , Khan Homam A , Bhardwaj Manish , Sangeetha C , Aarthi G , John Sujit , Thara R , Raghavan Vijaya 
Published: October 2020

Background: Perinatal depression (PND) is one of the most common psychiatric illnesses in women, with a prevalence around 22% in India. Leveraging mobile-based technologies could help in the prevention and treatment of perinatal depression even in remote places. Understanding the experiences and barriers of using such technology interventions by perinatal mothers could help in the better design and in delivery of these interventions. We aimed to study the experiences of the perinatal women using a mobile phone-based intervention, Interactive Voice Response System (IVRS), for the prevention and management of perinatal depression in a rural district of Bihar, India. Materials and methods: A total of 12 in-depth interviews (IDIs) and one focus group discussion (FGD) with eight participants were conducted with perinatal mothers using the mobile-based IVRS to explore the experiences and perspectives of women receiving mobile phone-based interventions for the treatment of PND. Thematic analysis was done to identify major themes. Results: Five major themes emerged from the study around accessibility, usability, community participation, cost and preference to either intervention. Women found the mobile-based intervention useful as it made them feel lighter. They considered mental health as a health issue and wanted help to address their problems. They became familiar with terms like anxiety, depression, helplessness and burden and bean using them in their conversations. The patients used therapeutic strategies such as breathing, coping and relaxation. They even agreed to take up sessions for their peer group. Conclusion: Women in rural Bihar seemed satisfied with the technology-based intervention. It has made mental health issues more visible and acceptable even in the rural hinterlands of Bihar.
The Consistency of Expectations: An Analysis of Learning Objectives Within Cognitive Assessment Course Syllabi
Authors: Bumpus Emily C. , Vinco Megan H. , Lee Kayla B. , Accurso Jenilee F. , Graves Scott L. 
Published: October 2020

Background: The course on cognitive assessment is mandatory for all school psychology programs. However, there have been no published studies that have explored learning objectives for this course. Objective: The purpose of this study is to examine content covered and complexity of learning objectives in the cognitive assessment course. Method: Five raters coded 90 syllabi from school psychology cognitive assessment courses across the United States on a sample of six American Psychological Association assessment-related standards and on complexity using the six Bloom’s Taxonomy levels. Results: The majority of objectives were addressing lower levels of complexity as measured by Bloom’s Taxonomy with few syllabi including learning objectives addressing a wide range of levels. Based on the analysis of objectives by the sample of Standards, learning objectives most frequently addressed administration accuracy and test selection, whereas integrating results and linking to recommendations were often missing. Conclusion: The learning objectives included in syllabi ranged in quantity, complexity, and content but focused on lower complexity skills. Learning objectives in cognitive assessment courses do not reflect the diverse assessment-related practice demands of school psychologists. Teaching Implications: To align training with future practice, instructors are advised to review learning objectives with attention to complexity and content standards.
Accuracy of multiparametric MRI in distinguishing the breast malignant lesions from benign lesions: a meta-analysis
Authors: Zhu Chun-Rong , Chen Ke-Yu , Li Pan , Xia Zhi-Yang , Wang Bin 
Published: October 2020

Background The sensitivity of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for detecting breast cancer was high and the specificity was relatively low. However, diffusion-weighted imaging (DWI) has a high specificity in the diagnosis of malignant lesions. Purpose To evaluate the accuracy of the multiparametric MRI (mp-MRI) in distinguishing the breast malignant lesions from the benign lesions. Material and Methods A comprehensive search of the PubMed, Embase, and Cochrane Library electronic databases was conducted up to March 2020. Data were analyzed for the following indexes: pooled sensitivity and specificity; positive likelihood ratio; negative likelihood ratio; diagnostic odds ratio; and the area under the curve. Results A total of 2356 patients with 1604 malignant and 967 benign breast lesions were included from 22 studies. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and area under the curve for mp-MRI were 0.93, 0.85, 6.3, 0.08, 81, and 0.96, respectively. The pooled sensitivity, specificity, and area under the curve for DCE-MRI alone were 0.95, 0.71, and 0.92, respectively. The pooled sensitivity, specificity, and area under the curve for DWI alone were 0.88, 0.84, and 0.93, respectively. Conclusion The mp-MRI did not improve the sensitivity but increased the specificity for the diagnosis of breast malignant lesions.
Outcomes of laparoscopic common bile duct exploration (LCBDE) after failed endoscopic retrograde cholangiopancreatography versus primary LCBDE for managing cholecystocholedocholithiasis
Authors: Kim Hanbaro , Shin Suk Pyo , Hwang Ji Woong , Lee Jung Woo 
Published: October 2020

Objective This study was performed to compare the outcomes of laparoscopic common bile duct exploration (LCBDE) after failed endoscopic retrograde cholangiopancreatography (ERCP) versus primary LCBDE for managing cholecystocholedocholithiasis. Methods We retrospectively analyzed data from 59 patients who underwent LCBDE during laparoscopic cholecystectomy (LC) for managing cholecystocholedocholithiasis from January 2013 to August 2019. The patients underwent either primary LCBDE plus LC (Group I) or LCBDE plus LC after failed ERCP (Group II). The demographics, reason for ERCP failure, perioperative details, and postoperative outcomes were evaluated. Results CBD stone removal using preoperative ERCP failed in 31 patients (Group II) because of remaining stones after ERCP (n = 9), failed cannulation (n = 6), failed sedation (n = 6), a periampullary diverticulum (n = 5), previous Billroth II gastrectomy (n = 3), a huge stone (n = 1), and an impacted stone (n = 1). The CBD stone clearance rate was >96% in both groups. The mean operative time, hospital stay, overall complication rate, and open conversion rate were not significantly different between the two groups. Conclusions When extraction of CBD stones by ERCP is likely to be difficult or fail, primary LCBDE is an acceptable alternative treatment for managing cholecystocholedocholithiasis.