bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contrasting effects of egg size and appearance on egg recognition and rejection response by Oriental reed warblers
Authors: Li Donglai , Li Xiaoshuang , Zhang Yan , Guan Shuang , Ruan Yanan 
Published: September 2020

AbstractBackgroundAmong potential hosts, the rejection of foreign eggs, which is a common and effective strategy to counter brood parasitism, depends on egg recognition. Multimodal and multicomponent recognition cues of brood parasitic eggs, which include both tactile (size, shape, and texture) and visual (size, shape, color, and maculation) cues, are potentially involved in the perception and discrimination of foreign eggs by hosts. An egg rejection experiment on the host with different types of model eggs can help to accurately assess the relative contribution of different components on egg recognition and constraints to rejection, in which videos can help identify the method of host rejection.MethodsHere, we assessed egg recognition and rejection responses by Oriental reed warblers (Acrocephalus orientalis), one of the most common hosts of common cuckoos (Cuculus canorus) which breed in eastern China. We designed six groups of model eggs for rejection experiments in which sensory cues included three grades of size and two categories of visual mimicry.ResultsOur experiments confirmed that the multimodal traits, which included variation in size, were significant predictors of egg rejection: We detected significantly higher rejection rates of mimetic spotted model eggs than of nonmimetic blue eggs. However, large model eggs did not yield higher rejection rates and, instead, these were less likely to be rejected and more likely to be deserted compared with smaller eggs. Further video‐recording data showed that there was no significant effect of egg size on the egg recognition rate (percentage of nests with evidence of egg pecking). No evidence that the egg appearance had an effect on the method of egg rejection (ejection or nest desertion) was found.ConclusionsOnly visual signals, such as color and maculation, contributed to the recognition of foreign eggs by Oriental reed warblers as recognizable clues, but not the egg size. The egg size had an impact on the type of egg rejection. It was less feasible for the warblers to eject large eggs and that is why they opted more often for desertion as the mean of model egg rejection. The significantly lower egg rejection rate of large eggs suggested that although some of them were recognized as foreign eggs, hosts failed to reject these eggs and finally the eggs were assumed to being accepted by the commonly used nest‐checking methods.
Kinetics and modeling of growth and lactic acid production in Gundruk, a Himalayan fermented vegetable dish
Authors: Ghimire Arjun , Kumar Sah Ajit , Poudel Ranjana 
Published: September 2020

AbstractGundruk is a fermented green leafy vegetable product prepared from fresh leaves of local vegetables called Rayo—sag (Brassica campestris), mustard (Brassica juncea), and cauliflower (Brassica oleracea) indigenous to the Nepali people. Fresh gundruk was prepared in a glass jar by fermenting the Brassica juncea leaves anaerobically for 16 days and the changes in biomass, lactic acid, and pH were evaluated after every 24 hr. The viable cell count increased from 6.03 × 104 cfu/g to 9.55 × 108 cfu/g after 3 days and then decreased gradually to remain constant after 8 days with 6.31 × 107 cfu/g until the end of fermentation. The lactic acid increased by about 12.58 times in 12 days and remained constant for the rest of the fermentation period. Unlike this, pH decreased from 6.59 to 3.71 on the 9th day of fermentation and then increased slightly till the last day of fermentation. The data obtained were fitted to two most widely accepted microbial growth models: Modified Gompertz, and Logistic model and three well‐known lactic acid production models: Luedeking‐ Piret, Monteagudo et al., and Balannec et al. model for lactic acid fermentation. Based on nonlinear regression analysis, Modified Gompertz, and Monteagudo et al. model gave a better fit to describe microbial growth and lactic acid production, respectively. The growth‐associated and non‐growth‐associated coefficients were determined to be 0.1104 and 0.0042, respectively, using Monteagudo et al. model. The findings revealed that lactic acid production in gundruk is a mixed type.
Valuation of VIX and target volatility options with affine GARCH models
Authors: Cao Hongkai , Badescu Alexandru , Cui Zhenyu , Jayaraman Sarath Kumar 
Published: September 2020

AbstractIn this paper we propose semiclosed‐form solutions, subject to an inversion of the Fourier transform, for the price of VIX options and target volatility options under affine GARCH models based on Gaussian and Inverse Gaussian distributions. We illustrate the advantage of the proposed analytic expressions by comparing them with those obtained from benchmark Monte–Carlo simulations. The empirical performance of the two affine GARCH models is tested using different calibration exercises based on historical returns and market quotes on VIX and SPX options.
Returning individual‐specific results of a dementia prevalence study: insights from prospective participants living in Switzerland
Authors: Fadda Marta , Fiordelli Maddalena , Amati Rebecca , Falvo Ilaria , Ibnidris Aliaa , Hurst Samia , Albanese Emiliano 
Published: September 2020

ObjectivesTo explore prospective participants' preferences regarding the return of their individual‐specific results from a dementia prevalence study (a probabilistic diagnosis of dementia).Methods/DesignWe conducted a qualitative study with 22 individuals aged 45 to 86 and resident in the Canton of Ticino (Switzerland). Participants had previously joined the validation phase of an epidemiological study into dementia and its impact.ResultsWe found that individuals welcome the return of their individual‐specific results, provided these meet a number of validity, clinical, and personal utility criteria. They justify researchers' duty to return study findings with the principles of beneficence (eg, providing information that can help participants' medical decision‐making) and justice (eg, acknowledging participants' efforts to help research by sharing their personal information). Furthermore, individuals anticipate societal benefits of the return of individual specific study findings, including improved interpersonal relationships among individuals and decreased dementia‐related stigma.ConclusionsOur findings suggest that researchers should address the return of individual‐specific study results early on during study design and involve prospective participants in identifying both the conditions under which results should be offered and the perceived individual and societal benefits returning can have.
Gain of LINC00624 Enhances Liver Cancer Progression by Disrupting the Histone Deacetylase 6/Tripartite Motif Containing 28/Zinc Finger Protein 354C Corepressor Complex
Authors: Li Zhe , Lu Xinyuan , Liu Yanfang , Zhao Jingjing , Ma Shengzhe , Yin Haoxiang , Huang Shenglin , Zhao Yingjun , He Xianghuo 
Published: September 2020

Background and Aims
Long noncoding RNAs (lncRNAs) are involved in almost every stage of tumor initiation and progression. Here, we have identified an antisense lncRNA, LINC00624, that arises from the antisense strand of chromo‐domain‐helicase‐DNA‐binding protein 1‐like (CHD1L), located on chr1q21.1, with significant copy number gain and transcriptional activation of CHD1L and B‐cell CLL/lymphoma 9 protein (BCL9), in hepatocellular carcinoma (HCC).

Approach and Results
Overexpression of LINC00624 enhances tumor growth and metastasis in vitro and in vivo. Mechanistically, higher levels of LINC00624 strengthen the interaction between histone deacetylase 6 (HDAC6) and tripartite motif containing 28 (TRIM28), which accelerates HDAC6 ubiquitination and degradation. Moreover, LINC00624 binds to the RBCC domain of TRIM28, inhibits trimer formation, and weakens the interaction between TRIM28 and zinc finger protein 354C (ZNF354C). Thus, LINC00624 overexpression disrupts the formation of the HDAC6‐TRIM28‐ZNF354C transcriptional corepressor complex, resulting in the dissociation of the complex from the promoter of CHD1L and BCL9, thereby removing transcription inhibition.

Conclusions
Our findings suggest that LINC00624 acts as a molecular decoy that sequesters the HDAC6‐TRIM28‐ZNF354C transcriptional corepressor complex away from the specific genomic loci, and that it can potentially be a therapeutic target in HCC.
Impact of the COVID‐19 pandemic on maternal health services in Pakistan
Authors: Sarwer Abdullah , Javed Bilal , Soto Erik B. , Mashwani Zia‐ur‐Rehman 
Published: September 2020

SummaryThroughout the world as health systems are being prepared to deal with the SARS‐CoV‐2 outbreak which will affect the management of HIV, diabetes, mental health and mainly maternal healthcare systems. As all efforts are focused on understanding the epidemiology, clinical features, transmission patterns, and management of the COVID‐19 outbreak, there has been very little concern expressed over the effects on maternal health services. It is highly likely that the present situation may exacerbate maternal mortality in suburban and rural areas. The present situation requires governments and NGOs to make necessary arrangements to support people with prenatal and postnatal care.
High‐performance work systems with internal and external contingencies: The moderating roles of organizational slack and industry instability
Authors: Kim Kwanghyun , Ok Chiho , Kang Sung‐Choon , Bae Johngseok , Kwon Kiwook 
Published: September 2020

AbstractWhen high‐performance work systems (HPWS) positively affect firm performance, both internal and external contingencies play potentially salient roles in its influence. Our study pays attention to organizational (unabsorbed) slack and industry instability as important boundary conditions in the relationship between HPWS and firm performance. Based on 307 Korean firms in 39 industries, our research found moderating effects of unabsorbed slack and industry instability in the relationship between HPWS and firm performance. We found that HPWS's positive effect on firm performance is strongest when a firm possesses more slack resources in an unstable industry.
The non‐payout functions of deposit insurance schemes
Authors: Kozińska Magdalena 
Published: September 2020

AbstractInstitutional and functional development of entities responsible for the provision of deposit insurance remains a marginal area of scientific research. The literature does not offer comprehensive analyses of the organization of deposit guarantee schemes (DGS), including the identification of all their possible tasks supporting the performance of its main goal (deposit insurance). Nevertheless, the potential synergies and cost savings justify broad range of tasks that could be carried out by DGSs in order to facilitate their functioning. At the same time, the problem of the functional shape of DGS is also of utmost practical importance. Therefore, the aim of this paper is to fill the identified gap by classifying the non‐payout functions and presenting the empirical review about them. To this end, the activities of 109 deposit guarantors around the world were analyzed. The review allowed to distinguish seven DGS functions supplementary to the payout of covered deposits, as well as to examine the interdependencies between the recognized roles and evaluate in terms of the DGSs' fulfillment of their objectives. Additionally, the advantages and disadvantages of every supplementary DGS activity were presented. The analysis allowed for the distinction of desired functions of deposit guarantee schemes.
Physiochemical characteristics: A robust tool to overcome teeth heterogeneity on predicting laser ablation profile
Authors: Loganathan Sarathkumar , Santhanakrishnan Soundarapandian , Bathe Ravi , Arunachalam Muthukumaraswamy 
Published: September 2020

AbstractTo avoid excessive tissue removal and collateral damage, the high‐power density laser is apt for dental surgery also need to have high precision. For high‐precision dental surgery with minimal tissue damage, the present work frames a method to predict laser ablation profile based on surface morphology and chemical composition of dentin. The surface morphology and chemical composition were studied on different dentin samples using scanning electron microscope (SEM) and Energy Dispersive X‐ray Analysis (EDAX), respectively. The key laser ablation parameters (ω0, Deff, and Fth) were determined by laser irradiation study using 800 nm, Ti:Sapphire femtosecond laser at processing condition of 100 fs, 10 kHz and 10 mm/s. The dentin samples show a strong linear correlation between physiochemical characteristics and laser ablation parameters. The surface morphology exhibits a negative linear correlation with threshold fluence, whereas the converse is true for chemical composition. The laser ablation parameters of a random dentin sample are derived from the knowledge of linearity data. From the obtained laser ablation parameters, the complete theoretical ablation profile is constructed and validated with experimental ablation profile. Even though the surface morphology of dentin shows high linearity, the concentration of Ca and P can be used as the most feasible probe in clinical settings. Furthermore, the laser ablation rate and ablation efficiency are predicted by the method to optimize the laser processing condition for any specific teeth. The versatility of the method overcomes the problem of heterogeneity on various teeth and simplifies the method of finding optimal laser processing condition for immaculate laser surgery.
Neuroactivity of naturally occurring proaporphine alkaloid, pronuciferine
Authors: Bayazeid Omer , Nemutlu Emirhan , Eylem Cemil C. , Yalçın Funda N. 
Published: September 2020

AbstractPronuciferine is a naturally occurring proaporphine alkaloid that belongs to isoquinoline alkaloids. The aim of this study is to investigate the neuroactivity of pronuciferine. We assessed the neuroprotective effect of pronuciferine against hydrogen peroxide (H2O2)‐induced apoptosis in human neuronal SH‐SY5Y cells. In addition, we measured the effect of pronuciferine on cell metabolites and brain‐derived neurotrophic factor (BDNF) level in SH‐SY5Y cells. In vitro result shows that pronuciferine at 10 µM significantly (P < .001) increased the proliferation of SH‐SY5Y by 45%, and upon H2O2 addition, pronuciferine significantly (P < .001) suppressed neuronal death caused by H2O2. Gas Chromatography‐Mass Spectrometry (GC‐MS) metabolomics study revealed that pronuciferine has a high impact on glycine‐serine‐threonine pathway by changing the intracellular level of serine dimethylglycine, sarcosine, and threonine. Also, pronuciferine increased the intercellular level of aspartic acid, glutamine, and tryptophan. Additionally, pronuciferine significantly (P < .05) increased the intracellular BDNF protein expression at 10 µM. Therefore, pronuciferine is a neuroactive molecule that might act as a neuroprotective agent to prevent apoptosis in neurodegenerative diseases.
DFT‐D4 counterparts of leading meta‐generalized‐gradient approximation and hybrid density functionals for energetics and geometries
Authors: Najibi Asim , Goerigk Lars 
Published: September 2020

AbstractPreviously, we introduced DFT‐D3(BJ)ωB97X‐V and ωB97M‐V functionals and assessed them for the GMTKN55 database [Najibi and Goerigk, J Chem. Theory Comput. 2018, 14, 5725]. In this study, we present DFT‐D4 damping parameters to build the DFT‐D4 counterparts of these functionals and assess these in comparison. We extend our analysis beyond GMTKN55 and especially turn our attention to enzymatically catalyzed and metal–organic reactions. We find that B97M‐D4 is now the second‐best performing meta‐generalized‐gradient approximation functional for the GMTKN55 database and it can provide noticeably better organometallic reaction energies compared to B97M‐D3(BJ). Moreover, the aforementioned DFT‐D3(BJ)‐based functionals have not been thoroughly assessed for geometries and herein we close this gap by analyzing geometries of noncovalently bound dimers and trimers, peptide conformers, water hexamers and transition‐metal complexes. We find that several of the B97(M)‐based methods—particularly the DFT‐D4 versions—surpass the accuracy of previously studied methods for peptide conformer, water hexamer, and transition‐metal complex geometries, making them safe‐to‐use, cost‐efficient alternatives to the original methods. The DFT‐D4 variants can be easily used with ORCA4.1 and above.
Urinary miR‐3137 and miR‐4270 as potential biomarkers for diabetic kidney disease
Authors: Li Xiaoyu , Xu Rong , Liu Xiangyang , Xu Linxin , Xue Mei , Cheng Ying , Li Ting , Yu Xiaochen , Wang Yue , Li Chunjun , Sun Bei , Chen Liming 
Published: September 2020

AbstractBackgroundAs one of the most prevalent diagnostic indicators of diabetic kidney disease (DKD), albumin‐to‐creatinine ratio (ACR) shows considerably limited predictive power in clinical application. We analyzed microarray expression profiling of urine to seek for differentially expressed miRNAs for potential biomarkers of DKD.MethodsUrine samples from type 2 diabetes mellitus (T2DM) patients with (30 mg/g < ACR < 300 mg/g, DKD group) or without DKD (ACR < 30 mg/g, DM group) were collected for miRNA microarray analysis. The differentially expressed miRNAs were screened by bioinformatics analysis and validated by quantitative real‐time PCR. Target genes of differentially expressed miRNAs were predicted in miRDB, Targetscan, and microRNA.org databases. We also conducted the Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathways analysis to explore for potential mechanisms in DKD.ResultsNine miRNAs were down‐regulated and seventeen miRNAs were up‐regulated in DKD group, compared to DM group. The levels of miR‐3137 and miR‐4270 in DKD group were 0.670 ± 0.505 and 2.116 ± 1.762 times than those in DM group, respectively, showing great significance. A total of 1076 target genes were simultaneously predicted by miRDB, Targetscan, and microRNA.org databases. According to the GO analysis results, disorders of endomembrane system may be one of the major pathological changes in DKD. In addition, Rap 1 signaling pathway is also altered obviously in DKD, discovered by the KEGG analysis.ConclusionMiR‐3137 and miR‐4270 show the potential for urinary biomarkers of DKD. The pathological changes of DKD may be related to disorders of endomembrane system and alternation of Rap1 signaling pathway.
Exposure to ethnic discrimination in social media and symptoms of anxiety and depression among Hispanic emerging adults: Examining the moderating role of gender
Authors: Cano Miguel Ángel , Schwartz Seth J. , MacKinnon David P. , Keum Brian T. H. , Prado Guillermo , Marsiglia Flavio F. , Salas‐Wright Christopher P. , Cobb Cory L. , Garcini Luz M. , De La Rosa Mario , Sánchez Mariana , Rahman Abir , Acosta Laura M. , Roncancio Angelica M. , de Dios Marcel A. 
Published: September 2020

AbstractMethodTwo hundred Hispanic emerging adults from Arizona (n = 99) and Florida (n = 101) completed a cross‐sectional survey, and data were analyzed using hierarchical multiple regression and moderation analyses.ResultsHigher social media discrimination was associated with higher symptoms of depression and generalized anxiety. Moderation analyses indicated that higher social media discrimination was only associated with symptoms of depression and generalized anxiety among men, but not women.ConclusionThis is likely the first study on social media discrimination and mental health among emerging adults; thus, expanding this emerging field of research to a distinct developmental period.
Proteomic analysis of aqueous humor from cataract patients with retinitis pigmentosa
Authors: Zhang Bi Ning , Wu Xiaoming , Dai Yunhai , Qi Benxiang , Fan Caixia , Huang Yusen 
Published: September 2020

AbstractA postcataract surgery complication in patients with retinitis pigmentosa (RP) is lens capsular contraction. To identify potential proteins contributing to this phenomenon, high‐performance liquid chromatography/mass spectrometry‐based proteomic analysis was conducted with aqueous humor samples collected from 11 patients who underwent cataract surgeries, with four patients diagnosed as RP and cataract (RP group) and the other seven with only senile cataract group. The upregulated proteins in the RP group were enriched in wound response, while downregulated proteins were enriched in cell adhesion and lens crystallins. Receptors of two dramatically upregulated proteins tenascin‐C (TNC) and serotransferrin were found expressed in human lens epithelial cells (HLEs). TNC can promote primary HLEs proliferation and cell line HLE‐B3 migration. This study indicates aqueous humor proteomic analysis serves as an effective way to unveil the pathogenesis of RP complications. TNC is a potential target of stimulating HLEs proliferation in RP concomitant cataract patients that worth further research.
A potential therapeutic effect of catalpol in Duchenne muscular dystrophy revealed by binding with TAK1
Authors: Xu Dengqiu , Zhao Lei , Jiang Jingwei , Li Sijia , Sun Zeren , Huang Xiaofei , Li Chunjie , Wang Tao , Sun Lixin , Li Xihua , Jiang Zhenzhou , Zhang Luyong 
Published: September 2020

BackgroundDuchenne muscular dystrophy (DMD) is a progressive muscle disease caused by the loss of dystrophin, which results in inflammation, fibrosis, and the inhibition of myoblast differentiation in skeletal muscle. Catalpol, an iridoid glycoside, improves skeletal muscle function by enhancing myogenesis; it has potential to treat DMD. We demonstrate the positive effects of catalpol in dystrophic skeletal muscle.Methodsmdx (loss of dystrophin) mice (n = 18 per group) were treated with catalpol (200 mg/kg) for six consecutive weeks. Serum analysis, skeletal muscle performance and histology, muscle contractile function, and gene and protein expression were performed. Molecular docking and ligand–target interactions, RNA interference, immunofluorescence, and plasmids transfection were utilized to explore the protective mechanism in DMD by which catalpol binding with transforming growth factor‐β–activated kinase 1 (TAK1) in skeletal muscle.ResultsSix weeks of catalpol treatment improved whole‐body muscle health in mdx mice, which was characterized by reduced plasma creatine kinase (n = 18, −35.1%, P < 0.05) and lactic dehydrogenase (n = 18, −10.3%, P < 0.05) activity. These effects were accompanied by enhanced grip strength (n = 18, +25.4%, P < 0.05) and reduced fibrosis (n = 18, −29.0% for hydroxyproline content, P < 0.05). Moreover, catalpol treatment protected against muscle fatigue and promoted muscle recovery in the tibialis anterior (TA) and diaphragm (DIA) muscles (n = 6, +69.8%, P < 0.05 and + 74.8%, P < 0.001, respectively), which was accompanied by enhanced differentiation in primary myoblasts from DMD patients (n = 6, male, mean age: 4.7 ± 1.9 years) and mdx mice. In addition, catalpol eliminated p‐TAK1 overexpression in mdx mice (n = 12, −21.3%, P < 0.05) and primary myoblasts. The catalpol‐induced reduction in fibrosis and increased myoblast differentiation resulted from the inhibition of TAK1 phosphorylation, leading to reduced myoblast trans‐differentiation into myofibroblasts. Catalpol inhibited the phosphorylation of TAK1 by binding to TAK1, possibly at Asp‐206, Thr‐208, Asn‐211, Glu‐297, Lys‐294, and Tyr‐293.ConclusionsOur findings show that catalpol and TAK1 inhibitors substantially improve whole‐body muscle health and the function of dystrophic skeletal muscles and may provide a novel therapy for DMD.