bluuebunny/crossref_metadata_2025_split huggingface dataset:
High or low glycemic index (GI) meals at dinner results in greater postprandial glycemia compared with breakfast: a randomized controlled trial
Authors: Haldar Sumanto , Egli Leonie , De Castro Carlos Antonio , Tay Shia Lyn , Koh Melvin Xu Nian , Darimont Christian , Mace Katherine , Henry Christiani Jeyakumar 
Published: April 2020

IntroductionWhile circadian control of glucose metabolism is well known, how glycemic index (GI) of carbohydrate-rich meals interacts with time of consumption (breakfast or dinner) to influence postprandial (PP) glucose homeostasis is less well established. The objective of the study was to assess markers of PP glucose homeostasis following high or low GI test meals (TM) consumed either at breakfast or at dinner and following consumption of the subsequent standardized meals (SSM).Research design and methodsRandomized crossover trial in 34 healthy, Chinese, elderly volunteers (mean±SEM age, 56.8±0.83 years), who completed 4 separate study sessions per-protocol, consisting of a high-GI breakfast, low-GI breakfast, high-GI dinner and low-GI dinner TM, followed by a SSM at the subsequent eating occasion. Blood samples were taken for 3 hours after each TM and SSM for glucose, insulin, glucagon, free fatty acids (FFA) and triglycerides (TG) measurements.ResultsConsuming TM at dinner produced greater PP glycemia than breakfast both after TM and SSM (both p<0.0001), irrespective of GI. High-GI TM also produced greater PP glycemia than low-GI TM, both after TM and SSM (both p<0.01), irrespective of time of consumption. No interaction between GI and time were found on PP glycemia, indicating parallel, but independent effects. Combined total areas under the curve of TM+SSM for PP glucose (p<0.0001), PP TG (p<0.0001) and PP FFA (p<0.0001) were all greater when TM taken during dinner compared with breakfast.ConclusionsCarbohydrate-rich meals consumed at dinner leads to significantly worse PP glucose homeostasis than when consumed at breakfast, on top of the independent GI effect of the meal. This may have implications to future type 2 diabetes risk. Moreover, future studies investigating GI/glycemic load (GL) and disease risk associations should factor in timing of GL consumption as an additional variable.Trial registration numberNCT02927600.
Reducing medicine-induced deterioration and adverse reactions (ReMInDAR) trial: study protocol for a randomised controlled trial in residential aged-care facilities assessing frailty as the primary outcome
Authors: Lim Renly , Bereznicki Luke , Corlis Megan , Kalisch Ellett Lisa M , Kang Ai Choo , Merlin Tracy , Parfitt Gaynor , Pratt Nicole L , Rowett Debra , Torode Stacey , Whitehouse Joseph , Andrade Andre Q , Bilton Rebecca , Cousins Justin , Kelly Lan , Schubert Camille , Williams Mackenzie , Roughead Elizabeth Ellen 
Published: April 2020

IntroductionMany medicines have adverse effects which are difficult to detect and frequently go unrecognised. Pharmacist monitoring of changes in signs and symptoms of these adverse effects, which we describe as medicine-induced deterioration, may reduce the risk of developing frailty. The aim of this trial is to determine the effectiveness of a 12-month pharmacist service compared with usual care in reducing medicine-induced deterioration, frailty and adverse reactions in older people living in aged-care facilities in Australia.Methods and analysisThe reducing medicine-induced deterioration and adverse reactions trial is a multicentre, open-label randomised controlled trial. Participants will be recruited from 39 facilities in South Australia and Tasmania. Residents will be included if they are using four or more medicines at the time of recruitment, or taking more than one medicine with anticholinergic or sedative properties. The intervention group will receive a pharmacist assessment which occurs every 8 weeks. The pharmacists will liaise with the participants’ general practitioners when medicine-induced deterioration is evident or adverse events are considered serious. The primary outcome is a reduction in medicine-induced deterioration from baseline to 6 and 12 months, as measured by change in frailty index. The secondary outcomes are changes in cognition scores, 24-hour movement behaviour, grip strength, weight, percentage robust, pre-frail and frail classification, rate of adverse medicine events, health-related quality of life and health resource use. The statistical analysis will use mixed-models adjusted for baseline to account for repeated outcome measures. A health economic evaluation will be conducted following trial completion using data collected during the trial.Ethics and disseminationEthics approvals have been obtained from the Human Research Ethics Committee of University of South Australia (ID:0000036440) and University of Tasmania (ID:H0017022). A copy of the final report will be provided to the Australian Government Department of Health.Trial registration numberAustralian and New Zealand Trials Registry ACTRN12618000766213.
Effect of time interval from diagnosis to treatment for non-small cell lung cancer on survival: a national cohort study in Taiwan
Authors: Tsai Chang-Hung , Kung Pei-Tseng , Kuo Wei-Yin , Tsai Wen-Chen 
Published: April 2020

ObjectivesThis study aimed to determine if treatment delay after non-small cell lung cancer (NSCLC) diagnosis impacts patient survival rate.Study designThis study is a natural experiment in Taiwan. A retrospective cohort investigation was conducted from 2004 to 2010, which included 42 962 patients with newly diagnosed NSCLC.MethodsWe identified 42 962 patients with newly diagnosed NSCLC in the Taiwan Cancer Registry from 2004 to 2010. We calculated the time interval between diagnosis and treatment initiation. All patients were followed from the index date to death or the end of 2012. Cox proportional hazard models were used to examine the relationship between mortality and time interval.ResultsWe included 42 962 patients (15 799 men and 27 163 women) with newly diagnosed NSCLC. The mortality rate exhibited a significantly positive correlation to time interval from cancer diagnosis to treatment initiation. The adjusted HRs ranged from 1.04 to 1.08 in all subgroups time interval more than 7 days compared with the counterpart subgroup of the interval from cancer diagnosis to treatment ≤7 days. The trend was also noted regardless of the patients with lung cancer in stage I, stage II and stage III.ConclusionsThere is a major association between time to treat and mortality of patients with NSCLC, especially in stages I and II. We suggest that efforts should be made to minimise the interval from diagnosis to treatment while further study is ongoing to determine causation.
Trends in attention-deficit and hyperactivity disorder (ADHD) medications among children and young adults in Ireland: a repeated cross-sectional study from 2005 to 2015
Authors: Mac Avin MaryJo , Teeling Mary , Bennett Kathleen E 
Published: April 2020

ObjectiveThis study examined the prescribing patterns of attention-deficit hyperactivity disorder (ADHD) medications in Ireland between 2005 and 2015 in children, adolescents and young adults, and concomitant use of psychotropic medication.DesignRepeated cross-sectional study.SettingCommunity setting using pharmacy claims data in Ireland.ParticipantsChildren and young adults aged 0–24 years.Primary and secondary outcomesAuthorised medications used to treat ADHD during the study period, methylphenidate, dexamfetamine, lisdexamfetamine dimesylate and atomoxetine were extracted from a national pharmacy claims database. Dispensing of concomitant psychotropic medications including antipsychotics, anxiolytics, hypnotics/sedatives and antidepressants were examined.ResultsThe number on any ADHD medication ranged from 1913 in 2005 to 4853 in 2015, and the prevalence rate per 1000 eligible population aged <25 years increased significantly over time from 5.61 (95% CI 5.36 to 5.86) in 2005 to 8.36 (95% CI 8.13 to 8.60) in 2015 (p<0.0001). Negative binomial regression showed significant changes over time for ADHD prescribing (p<0.001), with significantly higher rates across the different age groups. The rates overall were three to five times higher in males. There was a significant increase in the percentage on concomitant antidepressants from 2% in 2005 to 6% in 2015 (p<0.001).ConclusionsThere were significantly higher rates of ADHD prescribing in children/adolescents and a significant increase in the coprescribing of antidepressants. The reasons for the increase are unclear but may reflect increasing awareness and diagnosis of the condition.
[18F]DCFPyL PET-MRI/CT for unveiling a molecularly defined oligorecurrent prostate cancer state amenable for curative-intent ablative therapy: study protocol for a phase II trial
Authors: Glicksman Rachel M , Metser Ur , Valliant John , Chung Peter W , Fleshner Neil E , Bristow Robert G , Green David , Finelli Antonio , Hamilton Robert , Stanescu Teodor , Hussey Douglas , Catton Charles , Gospodarowicz Mary , Warde Padraig , Bayley Andrew , Breen Stephen , Vines Doug , Jaffray David A , Berlin Alejando 
Published: April 2020

IntroductionThe oligometastatic (OM) disease hypothesis of an intermediate metastatic state with limited distant disease deposits amenable for curative therapies remains debatable. Over a third of prostate cancer (PCa) patients treated with radical prostatectomy and postoperative radiotherapy experience disease recurrence; these patients are considered incurable by current standards. Often the recurrence cannot be localised by conventional imaging (CT and bone scan). Combined anatomical imaging with CT and/or MR with positron emission tomography (PET) using a novel second-generation prostate-specific membrane antigen (PSMA) probe, [18F]DCFPyL, is a promising imaging modality to unveil disease deposits in these patients. A new and earlier molecularly defined oligorecurrent (OR) state may be amenable to focal-targeted ablative curative-intent therapies, such as stereotactic ablative radiotherapy (SABR) or surgery, thereby significantly delaying or completely avoiding the need for palliative therapies in men with recurrent PCa after maximal local treatments.Methods and analysisThis ongoing single-institution phase II study will enrol up to 75 patients total, to include up to 37 patients with response-evaluable disease, who have rising prostate-specific antigen (range 0.4–3.0 ng/mL) following maximal local therapies with no evidence of disease on conventional imaging. These patients will undergo [18F]DCFPyL PET-MR/CT imaging to detect disease deposits, which will then be treated with SABR or surgery. The primary endpoints are performance of [18F]DCFPyL PET-MR/CT, and treatment response rates following SABR or surgery. Demographics and disease characteristics will be summarised and analysed descriptively. Response rates will be described with waterfall plots and proportions.Ethics and disseminationEthics approval was obtained from the institutional Research Ethics Board. All patients will provide written informed consent. [18F]DCFPyL has approval from Health Canada. The results of the study will be disseminated by the principal investigator. Patients will not be identifiable as individuals in any publication or presentation of this study.Trial registration numbersNCT03160794
Effectiveness and feasibility of internet-based and mobile-based interventions for individuals experiencing bereavement: a systematic review protocol
Authors: Luppa Melanie , Löbner Margrit , Pabst Alexander , Schlapke Christine , Stein Janine , Riedel-Heller Steffi G 
Published: April 2020

IntroductionInternet-based and mobile-based interventions (IMIs) provide an innovative and efficient self-management tool for mental health problems. This systematic review aims to summarise and critically evaluate studies addressing the effectiveness and feasibility of IMIs for normal and complicated grief in bereaved adults.Methods and analysisThe databases MEDLINE, Cochrane Library, PsycINFO, Embase and Web of Science and Google Scholar (for ‘grey’ literature) will be systematically searched for feasibility studies or randomised controlled trials of IMIs for bereaved adults who were experiencing normal/complicated grief. Data will be extracted and evaluated independently by two reviewers from studies eligible for inclusion. Quality of evidence will be assessed, and results will be synthesised qualitatively and pooled meta-analytically, if sufficient outcome data are available. Preferred Reporting Items for Systematic Reviews and Meta-Analyses standards and Grades of Recommendation, Assessment, Development and Evaluation methodology will be used.Ethics and disseminationNo primary data will be collected; thus, ethical approval is not required. The results will be disseminated through a peer-reviewed publication and conference presentations.Trial registration numberCRD42019131428.
Clinician-recalled quoted speech in electronic health records and risk of suicide attempt: a case–crossover study
Authors: Jayasinghe Lasantha , Bittar André , Dutta Rina , Stewart Robert 
Published: April 2020

ObjectiveClinician narrative style in electronic health records (EHR) has rarely been investigated. Clinicians sometimes record brief quotations from patients, possibly more frequently when higher risk is perceived. We investigated whether the frequency of quoted phrases in an EHR was higher in time periods closer to a suicide attempt.DesignA case–crossover study was conducted in a large mental health records database. A natural language processing tool was developed using regular expression matching to identify text occurring within quotation marks in the EHR.SettingElectronic records from a large mental healthcare provider serving a geographic catchment of 1.3 million residents in South London were linked with hospitalisation data.Participants1503 individuals were identified as having a hospitalised suicide attempt from 1 April 2006 to 31 March 2017 with at least one document in both the case period (1–30 days prior to admission) and the control period (61–90 days prior to admission).Outcome measuresThe number of quoted phrases in the control as compared with the case period.ResultsBoth attended (OR 1.05, 95% CI 1.02 to 1.08) and non-attended (OR 1.15, 95% CI 1.04 to 1.26) clinical appointments were independently higher in the case compared with control period, while there was no difference in mental healthcare hospitalisation (OR 0.99, 95% CI 0.98 to 1.01). In addition, there was no difference in the levels of quoted text between the comparison time periods (OR 1.09, 95% CI 0.91 to 1.30).ConclusionsThis study successfully developed an algorithm to identify quoted speech in text fields from routine mental healthcare records. Contrary to the hypothesis, no association between this exposure and proximity to a suicide attempt was found; however, further evaluation is warranted on the way in which clinician-perceived risk might be feasibly characterised from clinical text.
Mapping the digital food environment: a scoping review protocol
Authors: Granheim Sabrina Ionata , Opheim Elin , Terragni Laura , Torheim Liv Elin , Thurston Miranda 
Published: April 2020

IntroductionFood environments are the interface through which people interact with the broader food system. They are a key determinant of healthy and sustainable diets. The widespread use of digital technology in late modernity and the shift towards a digital society have posed new challenges for nutrition and health, with a concomitant surge in research on social media, digital health promotion interventions, and more recently, increasing interest in digital food marketing. While the literature is abundant on studies linking food, nutrition and digital technology, the effort to conceptualise and describe the digital food environment is new. This scoping review aims to support the development of a definition of the digital food environment and characterise it, along with key thematic research trends on this topic and potential consequences for nutrition and health.Methods and analysisThe planned scoping review will be supported by the methodological framework proposed by Arksey and O’Malley and further developed by Levacet al. Development and reporting will follow the Preferred Reporting Items for Systematic Reviews and MetaAnalyses—Extension for Scoping Reviews (PRISMA-ScR) checklist and guidelines. The development of the search strategy was guided by the food environment conceptual framework developed by Turneret al. Four databases will be searched: MEDLINE, EMBASE, Scopus and Web of Science. Citation searching will be applied to identify additional studies, through checking of reference lists of primary studies and reviews. Studies in English, published from the year 2000 onwards, will be included. No geographical or population limits will be applied. Data will be extracted and analysed using a standardised charting tool.Ethics and disseminationNo ethical approval is required for this study. The results will be submitted to an international peer-reviewed journal and scientific conferences. They will be disseminated through digital science communication platforms, including academic social media, to amplify its reach and usefulness.
Concentration of dipotassium ethylenediaminetetraacetic acid but not lithium heparin affects total protein determination in equine synovial fluid
Authors: Jimenez Rihuete Pablo , Villarino Nicolas , Pelisiak Alicja , Rubio‐Martinez Luis M 
Published: April 2020

BackgroundRefractometric determination of total protein (TP) in synovial fluid (SF) is commonly used for diagnosis and monitoring of synovial sepsis in horses. Previous studies have shown that elevated concentrations of certain anticoagulants may overestimate refractometric determination of TP concentration.ObjectivesThe aim of the study was to evaluate the effect of different concentrations of dipotassium EDTA (K2EDTA) and lithium heparin (LH) on TP determination by using a hand‐held refractometer in equine synovial fluid.Study designCross‐section observational study.MethodsThirty samples of synovial fluid obtained from 22 horses with different synovial conditions were collected. Synovial fluid samples were separated into different aliquots and placed in commercially available collection tubes containing K2EDTA or LH at four different concentrations (1.76, 3.52, 7.04 and 17.6 mg/ml for K2EDTA; 16, 32, 64 and 160 IU/ml for LH). Refractometric TP determination was performed on untreated and K2EDTA and LH aliquots with a hand‐held refractometer and by spectophotometric Biuret method as the gold standard.ResultsRefractometric TP determination was overestimated in SF samples containing 10 times the recommended K2EDTA concentrations. Lower concentrations of K2EDTA and LH concentrations did not affect refractometric TP determinations.Main limitationsLimited number of samples mostly obtained from large synovial structures.ConclusionTo avoid incorrect TP determination, the use of LH containing collection tubes may be an appropriate alternative when the SF volume available is not enough to fill the K2EDTA collection tube.
Impact of Higgs physics on the parameter space of the $$\mu \nu \mathrm{SSM}$$
Authors: Kpatcha Essodjolo , López-Fogliani Daniel E. , Muñoz Carlos , de Austri Roberto Ruiz 
Published: April 2020

AbstractGiven the increasing number of experimental data, together with the precise measurement of the properties of the Higgs boson at the LHC, the parameter space of supersymmetric models starts to be constrained. We carry out a detailed analysis of this issue in the framework of the $$\mu \nu $$μνSSM. In this model, three families of right-handed neutrino superfields are present in order to solve the $$\mu $$μ problem and simultaneously reproduce neutrino physics. The new couplings and sneutrino vacuum expectation values in the $$\mu \nu $$μνSSM induce new mixing of states, and, in particular, the three right sneutrinos can be substantially mixed with the neutral Higgses. After diagonalization, the masses of the corresponding three singlet-like eigenstates can be smaller or larger than the mass of the Higgs, or even degenerated with it. We analyze whether these situations are still compatible with the experimental results. To address it we scan the parameter space of the Higgs sector of the model. In particular, we sample the $$\mu \nu $$μνSSM using a powerful likelihood data-driven method, paying special attention to satisfy the constraints coming from Higgs sector measurements/limits (using and ), as well as a class of flavor observables such as B and $$\mu $$μ decays, while muon $$g-2$$g-2 is briefly discussed. We find that large regions of the parameter space of the $$\mu \nu $$μνSSM are viable, containing an interesting phenomenology that could be probed at the LHC.
The effect of UV irradiation on the dielectric properties of bionanocomposites with fillers of biological origin and metal nanoparticles
Authors: Gojayev E. M. , Aliyeva Sh. V. , Salimova V. V. , Jabarov S. H. 
Published: April 2020

In this paper, information is given about the investigation of the dielectric properties of bionanocomposites modified with fish bones (FBs) and scales and metal nanoparticles (Al, Fe) with 50–80 nm dimension before and after ultraviolet (UV) irradiation, depending on the temperature, the irradiation time and the volume content of fillers. The investigations of dielectric permittivity and dielectric loss were carried out in the temperature range 300–390 K, the time of irradiation with UV rays were 50, 100, 70 and 150 h, and the filler contents were 3, 5, 7, 10, 15 vol.% and nanoparticles 1 vol.% Al (Fe). It was found that the dielectric constant of UV-irradiated biocomposites with FB additives increases and the dielectric loss decreases. An increase in dielectric constant is also observed with an increase in the volume content of a biological origin filler. Note that the effect of UV irradiation causes the appearance of a new region of dielectric loss in the temperature-dependent tan[Formula: see text] of the polyethylene. However, in modified samples after irradiation, under the same conditions, the change in dielectric properties is much less pronounced than in the initial ones, i.e. the dielectric constant increases monotonically, and the value of tan[Formula: see text] in the maximum of the new loss region is much smaller. Moreover, the effect of the additive is manifested in slowing down the process of LDPE oxidation in the irradiation zone, since the main losses of the polyethylene are primarily caused by the relaxation of the carbonyl groups. Thus, the observed dependences of [Formula: see text] and tan[Formula: see text] on the time of exposure to UV rays are explained by a change in the physical structure of the polymer matrix and the boundary layer of the components composition under the action of charges formed during irradiation.