bluuebunny/crossref_metadata_2025_split huggingface dataset:
P006 Health-Related Quality of Life in Brazilian Adolescents and Young Adults (AYA) With Inflammatory Bowel Disease
Authors: Oba Jane , Deboni Mariana , Toma Ricardo , Sobrado Carlos , Borba Marcelo , Azevedo Matheus , Carlos Alexandre , Queiroz Natália , Damião Adérson , Silva Clóvis Artur 
Published: December 2019

BACKGROUND:
IBD comprises Crohn ́s disease (CD) and ulcerative colitis (UC), both are characterized by unpredictable exacerbations and remissions. The incidence is highest in adolescence and early adulthood and alike other chronic disease have a considerable impact upon patients' HRQoL. Few studies assessing HRQoL have been performed in AYA populations. Our objectives were to assess the health related quality of life (HRQoL) in adolescents and young adults (AYA) patients with inflammatory bowel disease (IBD) and analyze the disease factors that could influence it.

METHODS:
59 AYA IBD patients (13-25y) at two gastroenterology units of tertiary hospitals were evaluated and compared to 60 AYA healthy controls (13-25y). 59 AYA IBD patients completed the Pediatric Quality of Life Inventory 4.0 (PedsQL4.0), Short Form Health Survey (SF-36) questionnaires and Pain Visual Scale, according to age. After we compared HRQoL between Crohn’s disease (CD) vs. UC (ulcerative colitis) in AYA population. The demographic data, extra-intestinal manifestation, overlap syndromes, disease active status, treatment and outcomes were also evaluated. All participants and the adolescents' legal guardian written informed consent form.

RESULTS:
PedsQL4.0 domain “school/work” and SF-36 domain “general health perception” was reduced in IBD AYA patients compared with healthy controls (p < 0.05). In addition, significantly lower score “health change” in SF-36 in comparison with healthy determined perceived differences in state of health over the past year. No difference in other domains and pain scale was observed between CD and UC AYA patients. Disease activity as well extra intestinal manifestations, overlap syndromes, treatments and outcomes did not influence the HRQoL of the AYA patients. Autoimmune sclerosing cholangitis and the use of prednisone were significantly higher among UC patients, whereas previous gut surgery was higher between CD patients. However, these disease factors did not significantly influence the HRQoL between CD vs UC. Mann-Whitney test and Fisher's test were used to compare continuous variables and comparison between groups, p-values were set at 5% (p < 0.05).

CONCLUSION(S):
HRQoL was significantly lower for AYA with IBD relative to healthy controls. These results highlight areas to focus clinical attention in adolescents and young adult patients with IBD for assessment and future interventions.
P029 Patient Perception and Clinical Impact of Direct-to-Consumer Advertising in Inflammatory Bowel Disease
Authors: Gu Phillip , Yang Edward , Chittajallu Punya , McNeill Cathy , Singal Amit , Kwon John , Ahmed Tasneem 
Published: December 2019

BACKGROUND:
Direct-to-consumer drug advertising is a controversial marketing strategy that can potentially empower patients and/or negatively impact clinical practice and the patient-provider relationship. With an increasing number of available therapies for inflammatory bowel disease (IBD), little is known about patients’ attitudes regarding IBD-related direct-to-consumer advertising (IBD-DTCA) and its impact on treatment decisions in clinical practice. We aim to characterize patient perception of IBD-DTCA and its impact on clinical decision making.

METHODS:
We administered a 58-item, mailed questionnaire to patients with IBD receiving Gastroenterology subspecialty care at a large academic health system. The survey assessed patient awareness and perception of IBD-DTCA and its effect on IBD treatment discussions and decisions. We used bivariate analysis to evaluate patient-level factors associated with awareness and favorable perception of IBD-DTCA.

RESULTS:
We achieved a response rate of 15.2% (n = 226 of 1486). Most patients (93.3%) reported awareness of IBD-DTCA, with adalimumab receiving the most exposure. A majority of respondents reported IBD-DTCA made them more aware of treatments they otherwise would not know about (53.6%), provided information in a balanced manner (63.5%), and taught them about new potential risks and side effects (64.5%). Patients without a college degree and those with a household income less than $75k per year perceived IBD-DTCA significantly more favorably. A minority of aware respondents reported IBD-DTCA made them less confident in their provider’s judgement (12.3%) and that a treatment option was being withheld (6.6%). Finally, IBD-DTCA rarely changed IBD management, with only 7.6% of respondents having a discussion with their provider about the advertised drug and only two respondents (0.9%) being initiated on the advertised drug.

CONCLUSION(S):
IBD patients were aware of IBD-DTCA and perceived it favorably; however, IBD-DTCA rarely led to patient-provider discussions or changes in treatment regimen.
P056 Methodology and Initial Results From TOUR (Tofacitinib Response in Ulcerative Colitis): A Real World Prospective Multicenter Study
Authors: Long Millie , Abdalla Maisa , McCabe Robert , Fischer Monika , Cohen Benjamin , Afzali Anita , Polyak Steven , Hanson John , Herfarth Hans 
Published: December 2019

BACKGROUND:
Tofacitinib is a janus kinase (JAK) inhibitor approved for use in ulcerative colitis (UC) in 2018. Prospective real-world data on tofacitinib use in UC patients are limited. We aimed to develop a unique electronic system to obtain patient reported outcomes (PROs) from patients initiating tofacitinib. We aimed to measure response to therapy on days 1-14, anxiety, depression and social satisfaction.

METHODS:
An initial sample of 23 patients were recruited from 8 academic and community gastroenterology practices. Complete demographic information, disease and medication histories were obtained. Patients completed PRO surveys on days 1-14 after initiation of tofacitinib via a unique electronic self-report system. Outcome data included the simple clinical colitis activity index (SCCAI), and PRO measurement information system (PROMIS) measures of depression, anxiety and social satisfaction. A score of ≤2 on SCCAI was considered to be remission; a score of <4 with a decrease by > 1.5 points was considered to be response. PROMIS measures were calibrated using a T score metric with the mean of the standard US population equal to 50, standard deviation (SD) of 10. A higher PROMIS score equates to more of the measure (higher scores worse for depression, anxiety and higher scores better for social satisfaction).

RESULTS:
A total of 23/23 (100%) completed electronic PRO data daily in the first 14 days after initiation of tofacitinib. Mean age of the population was 40.7 (SD 18.1), 56.5% were male, mean disease duration was 11.3 years and 73.9% were on concomitant steroids. Mean disease activity at baseline (n = 23) was active (SCCAI of 4.0), with reductions in mean daily disease activity to a nadir of SCCAI 2.2 on day 14. Among patients initiating tofacitinib without concomitant corticosteroid use (n = 6), similar early reductions in SCCAI were seen (mean SCCAI 4.0 at baseline, reduced to 1.8 by day 4). Improvements in all PROMIS measures (anxiety, depression, social satisfaction) were seen in the population by day 7. A total of 8/12 (66.7%) with active disease at baseline met criteria for response at day 14.

CONCLUSION(S):
Real time electronic PRO data capture directly from UC patients is feasible. This ongoing prospective multi-center real-world cohort demonstrated an excellent patient adherence to the online platform in the first 14 days. Initial data suggest a rapid response to tofacitinib in this sample, with improvements in disease activity, depression, anxiety and social satisfaction. Continued enrollment and long-term follow-up data from this cohort will enhance our knowledge of tofacitinib use in real world UC populations.
P079 Real-World Prescribing Patterns of Certolizumab in the Treatment of Crohn’s Disease
Authors: Ritter Timothy , Fourment Chris , Kuten Samantha , Van Anglen Lucinda 
Published: December 2019

BACKGROUND:
Certolizumab (CZP) is a pegylated anti-tumor necrosis factor (TNF) agent approved for the treatment of moderate-to-severe Crohn’s disease (CD). CZP therapy has proven effective and well-tolerated for biologic-naïve patients, as well as anti-TNF-experienced patients with secondary non-response or intolerance. CZP is also the preferred anti-TNF during pregnancy. We sought to describe real-world prescribing patterns of CZP in the treatment of CD.

METHODS:
We performed a retrospective cohort study of CD patients treated with CZP at a large multicenter gastroenterology private practice since drug approval in 2014. Data collection included demographics, diagnosis, treatment history, and reason for CZP use. CZP use was classified as one of the following: first-line anti-TNF, prior anti-TNF non-response or intolerance, payor requirements, and/or pregnancy considerations.

RESULTS:
A total of 59 patients receiving CZP for the treatment of CD were identified. Mean age was 48 ± 16.1 years and 42 (71%) were female. Median CZP treatment duration was 26 [IQR 9-50] months. Forty-four (78%) patients had private insurance, 12 (20%) were enrolled in Medicare or Medicaid, and 1 was uninsured. Nine (15%) patients were bio-naive. Of the 50 (85%) biologic-experienced patients, 22 were previously treated with 1 agent, 23 received 2 previous agents, and 5 patients received 3 or more previous agents. Reasons for CZP use were as follows: prior anti-TNF non-response or intolerance in 39 (66%), pregnancy considerations in 8 (14%), payor requirements or cost considerations in 6 (10%), first-line anti-TNF in 4 (7%), and other reasons in 2 (3%). To date, 26 (44%) patients remain on CZP with a median treatment duration of 48 [IQR 31-59] months.

CONCLUSION(S):
We described real-world utilization of CZP. In our cohort, CZP was most commonly prescribed to biologic-experienced patients with prior anti-TNF non-response or intolerance.
P102 Mortality in Mexican Population With Inflammatory Bowel Disease Treated in a Tertiary Care Hospital in Mexico City
Authors: Trujillo de la Fuente Korely , López Goméz Jesús , Cortes Espinosa Tomas , Ramos Gómez Mayra , Aleman Abitia Dassaev , Navarro Gerrard Christian , Ramirez del Pilar Rodolfo , Aguilar Hernandez Jhonatan , Klimek Albarrán Gabriel 
Published: December 2019

BACKGROUND:
Inflammatory bowel disease (IBD) is a chronic idiopathic, inflammatory process of the gastrointestinal tract without a known cause. IBD is divided into Crohn’s disease (CD) and Ulcerative Colitis (UC). In Latin-American IBD presents with low frequency. Due to the severe deterioration of the quality of life, risk of developing malignancies and mortality they are considered of great clinical importance. Since the management of the disease has varied in recent years, it is necessary to know the magnitude of the inflammatory bowel disease and its associated mortality.

METHODS:
A historical cohort of patients from the IBD clinic in the Centro Médico Nacional 20 de Noviembre ISSSTE was analysed in the time frame corresponding from 20 years. All patients met diagnostic criterion for IBD. Study: descriptive, retrospective and transversal. Relative and central frequency averages were used to obtain percentages, averages and standard deviation. Chi square test was used for qualitative variables and Student's T-test was used for continuous numerical quantitative variables. Risk calculation (OR) was made from cross tables to show the prediction of mortality.

RESULTS:
A total of 103 patients with IBD were included, 72 patients had UC of which 52.8% were female with a mean age of 50 ± 15.8 years and 31 patients had Crohn of which 58.1% were female with a mean age of 52.3 ± 16.6 years. In the UC group 48.6% were in treatment with biological agents and 51.4% were on immunosuppressants and other treatments (mesalazine and steroids). In the CD group 77.4% were treated with biological agents and 22.6% were on immunosuppressants and other treatments (mesalazine and steroids). Surgical treatment was required in 22.3% of the patients. A total mortality of 9.7% was reported and predominated in UC (50% due to post-surgical complications, 40% secondary to sepsis, 10% metastasis). In the risk calculation (OR) performed for the prediction of mortality, no significant difference was found in terms of type of disease (P = 0.34, OR 1.63, 95% CI 0.42-6.23), gender (P = 0.51, OR 1.21, 95% CI 0.32-4.47), or biological treatment (P = 0.73, OR 0.96, 95% CI 0.93-0.96). In patients undergoing surgical treatment, they obtained a statistically significant result with P = 0.008, OR 6.70, 95% IC 1.7-26.3.

CONCLUSION(S):
The mortality rate in patients with IBD in this study was of 9.7%. The group where more deaths were reported was in the UC group. Statistical significance was found when analysing surgical procedure as a predictor of mortality. Due to the small sample size, a prospective randomized study to confirm these findings is needed. This work has no conflict of interest.
P103 Ileocecal Obstruction Secondary to Campylobacter Jejuni Ileitis
Authors: Diem Vu T.N. , Watkins Ryan , Hanada Yuri , Schupack Daniel , Oblizajek Nicholas , Chua Heidi , Papadakis Konstantinos 
Published: December 2019

BACKGROUND:
Acute ileitis is most classically associated with inflammatory bowel disease. However, several infections can also cause inflammation or obstruction of the terminal ileum. Clinical presentation is usually acute and characterized by abdominal pain of the right abdomen.

CASE REPORT:
We report the case of a healthy 24 year-old man who presented with a two month history of right lower quadrant pain, nausea and emesis after returning from a trip to South Africa. Over the subsequent two months, he had continued symptoms and an ileocecal obstruction was demonstrated both on cross-sectional imaging and on colonoscopy. A stool pathogen panel was positive for Campylobacter jejuni, and he completed an empiric three-day course of azithromycin. Endoscopic biopsies were negative for histologic features of inflammatory bowel disease. After three hospitalizations for recurrent obstruction, an ileocecal resection was performed. The resection specimen revealed marked eosinophilia within the muscularis propria and submucosal fibrosis. The patient made an uneventful recovery following his surgery.

CONCLUSION:
Although inflammatory bowel disease should be excluded during the workup of terminal ileitis, this case illustrates the importance of including infections and post-infectious sequelae in the differential, especially in otherwise healthy patients with recent travel history.
Conceções dos professores portugueses sobre multilinguismo e práticas educativas em salas de aula multilingues
Authors: Martins Margarida Alves , Sousa Otília , Castro São Luís , Dockrell Julie , Papadopoulos Timothy , Mifsud Charles 
Published: December 2019

A Europa é uma realidade linguística diversa e heterogénea que enfrenta o desafio de educar uma população cada vez mais multicultural e multilingue. Os professores de língua(s) são atores nesta realidade, promovendo o multilinguismo e integrando a diversidade. Portugal não foge ao paradigma do multilinguismo e as escolas e professores portugueses vão-se adaptando a uma realidade que, não sendo nova, tem novos contornos. Neste artigo, analisam-se as conceções de professores portugueses sobre multilinguismo e as práticas educativas desenvolvidas em salas de aula multilingues por eles referidas. Os participantes foram 505 professores de todos os ciclos de ensino a lecionar em salas de aula multilingues. O instrumento utilizado foi um questionário criado pelo Grupo Multilingue da Rede Europeia de Literacia traduzido e adaptado para Portugal que foi respondido online. Os resultados mostram uma baixa concentração de imigrantes por turma, o lugar de destaque do inglês como segunda língua, professores com uma atitude de abertura face à diversidade linguística, multilingues e esclarecidos acerca do multilinguismo, valorizando a língua e cultura dos estudantes. Acreditam que o conhecimento de línguas se constitui como uma mais-valia no desenvolvimento académico e cognitivo dos estudantes.
Cómo propiciar en los estudiantes una lectura inferencial
Authors: Lizarazú Bernal Betty Concepción 
Published: December 2019

Pocas veces la enseñanza de la lectura resulta eficiente frente al favorecimiento de la capacidad inferencial en los estudiantes, es decir, a la habilidad de elaborar hipótesis de sentido que certifiquen un proceso que asegure la comprensión tras la explicitación de elementos latentes en la estructura interna de los textos; más bien, se observa con frecuencia que los estudiantes leen de manera espontánea e inocente en un ambiente pedagógico donde los docentes mismos no se presentan como modelo de un lector avezado. En el presente artículo, se muestran los avances de una investigación, la cual se ha valido de métodos cualitativos de las ciencias sociales, tales como la investigación acción participativa, hermenéutica, etnográfico y el análisis de documentos. A partir de la aplicación metodológica es que hemos podido constatar estas dificultades lectoras en la población estudiantil. Frente a este panorama, Eco (1999), Aparici (1998) y Rodríguez (2006), entre otros autores, trazan caminos que coadyuvan a la enseñanza de la lectura con sentido. Ahora bien, a partir de lo anterior, resulta viable plantear y desarrollar una propuesta que contribuya a la cualificación de habilidades inferenciales y abductivas, desde otra mirada que facilite los procesos de comprensión lectora en un grupo de estudiantes que inician su secundaria, utilizando como pretexto el uso de formatos visuales, de manera más concreta la historieta o cómic.
Polyaniline Modified Natural Zeolite as Adsorbent for Chromium(III) Metal Ion
Authors: Nurianingsih Rina , Sriatun Sriatun , Darmawan Adi 
Published: December 2019

Zeolite is an inorganic material whose surface has a permanent negative charge in its crystal structure. This material consists of tetrahedral [SiO4]-4 and [AlO4]-5, which are connected by oxygen atoms in such a way as to form an open three-dimensional framework containing canals and cavities, as well as alkali or alkali metals for balancing the negative charge. This structure makes zeolites have the ability to adsorb. The ability of natural zeolite adsorption can improve by modifying the surface by adding polyaniline cationic compounds (PANI), which have an amine group (: NH2). Moreover, environmental pollution by metals is the biggest problem in daily life, one of which is the metal ion Cr(III), which is a waste from industrial processes. Therefore, it is necessary to have an effort to reduce waste. This study aims to determine the effect of the addition of polyaniline on the adsorption ability of natural zeolites to metal ions Cr(III). The research was carried out in several stages, namely activation of natural zeolite using HF 1%, modification with polymer from aniline monomers, and ammonium peroxidisulphate (APS), and testing the ability of adsorption on Cr(III) metal ions. The study on the ability to adsorb Cr(III) metal ions by PANI-modified zeolites was carried out on variations in the concentration of Cr(III) metal ions and the system pH. The results showed that natural zeolite successfully modified with PANI. The FTIR absorption band at wavenumber 1303 -1319 cm-1 and 1597 cm-1 indicated the presence of NH functional groups. Meanwhile, adsorption capability test data showed that the best adsorbent for adsorption of Cr(III) metal ions was zeolite-PANI 0.01M. The best pH was 4, the initial concentration of Cr(III) metal ions was 1000 ppm, and the percentage of absorption is 48.13%.
Study of Equilibrium and Kinetics of Pb(II) in Solution Using Persimmon Tannin Gel as an Adsorbent
Authors: Azis Thamrin , Ahmad La Ode , Rosa Fajrin E. , Kadir Laode Abdul 
Published: December 2019

Heavy metals concentrations exceeding the recommended threshold are hazardous for the environment, so there is a need for handling it safely. The purpose of this research was to determine the adsorption capacity and kinetics of adsorption. This research uses an adsorption method in the process of removing Pb(II) heavy metal ions using persimmon tannin gel. Besides the influence of contact time, pH, and the concentration of Pb(II) metal ions on adsorption, a kinetics study was also carried out. The adsorption rate is obtained through the adsorption rate constant (K) and the reaction order generated from the kinetics model. Based on the results of the research, showed the optimum adsorption process, which is 20 minutes and at a pH of 5. The maximum adsorption capacity of 17.62 mg/g with the value of the standard energy changes of Gibbs adsorption (-ΔG° = -14.274 kJ/moll) indicates that the adsorption takes place through physical interaction. The kinetic adsorption gives the adsorption rates a constant of, k = 0.008231 g/mg.min.
Sekundärregelung und Koordination verkoppelter Microgrids
Authors: Hermann Jonathan , Hammer Bernhard , Konigorski Ulrich 
Published: December 2019

Zusammenfassung
Der vorliegende Beitrag behandelt die hierarchische Regelung von Microgrids mit leistungselektronischer Einspeisung sowie die Verkopplung solcher Microgrids zu Verbundnetzen. Zur Regelung einzelner Microgrids wird eine Sekundärregelung vorgeschlagen, die auf einer Lastschätzung und einem Ausgangsregulierungsansatz basiert. Sie erzielt stationäre Genauigkeit in Frequenz und Leistungsaufteilung. Um den Verbund von auf diese Weise sekundärgeregelten Microgrids zu koordinieren, wird schließlich ein konsensusbasierter Ansatz zur Tertiärregelung präsentiert.
Surrogate models in bidirectional optimization of coupled microgrids
Authors: Baumann Manuel , Grundel Sara , Sauerteig Philipp , Worthmann Karl 
Published: December 2019

Abstract
The energy transition entails a rapid uptake of renewable energy sources. Besides physical changes within the grid infrastructure, energy storage devices and their smart operation are key measures to master the resulting challenges like, e. g., a highly fluctuating power generation. For the latter, optimization based control has demonstrated its potential on a microgrid level. However, if a network of coupled microgrids is considered, iterative optimization schemes including several communication rounds are typically used. Here, we propose to replace the optimization on the microgrid level by using surrogate models either derived from radial basis functions or neural networks to avoid this iterative procedure. We prove well-posedness of our approach and demonstrate its efficiency by numerical simulations based on real data provided by an Australian grid operator.