bluuebunny/crossref_metadata_2025_split huggingface dataset:
No relationship between dopamine D3 receptor gene Ser9Gly polymorphism (rs6280) and schizophrenia: a meta-analysis of family-based association studies
Authors: Li Xiao-na , Zheng Ji-long , Wei Xiao-han , Wang Bao-jie , Yao Jun 
Published: November 2019

Abstract
Background Ser9Gly (rs6280) is a functional single nucleotide polymorphism (SNP) in the human dopamine receptor D3 gene (DRD3). It is still controversial that whether Ser9Gly is involved in the occurrence of schizophrenia. Thus, a meta-analysis of family-based studies was performed to explore the role of Ser9Gly in the etiology of schizophrenia.Methods The published family-based association studies were searched from the relevant literature databases according to the established inclusion criteria. We generated odds ratios and 95% confidence intervals in order to determine the strength of the relationship between Ser9Gly SNP and the occurrence of schizophrenia.Results We finally pooled up 13 family-based association studies between Ser9Gly SNP and schizophrenia. It contained 11 transmission disequilibrium test (TDT) studies with 1219 informative meiosis and 5 haplotype-based haplotype relative risk (HHRR) studies. There was no statistical significance for the heterogeneity in TDT and HHRR studies. Therefore, the fixed effect model was used to measure the pooled effect size. The results showed that neither of the associations between Ser9Gly and the risk of schizophrenia were observed in TDT (1219 samples, OR=1.005, 95% CI = 0.898-1.125, Z-value = 0.086, p = 0.932) and HHRR studies (1704 samples, OR=0.869, 95% CI = 0.713-1.059, Z-value = -1.395, p = 0.163), except for the significantly preferential transmission of DRD3 Ser9 allele in East Asian in TDT studies (204 samples, OR=0.744, 95% CI = 0.564-0.980, Z-value = -2.104, p = 0.035).Conclusions Our meta-analysis found no association between DRD3 gene Ser9Gly polymorphism and the risk of schizophrenia. However, more effects need to further confirm the function of DRD3 Ser9Gly SNP in the occurrence of schizophrenia.
Effect of climatic factors on the seasonal fluctuation of human brucellosis in Yulin, Northern China
Authors: Liu Kun , Yang Zurong , Liang Weifeng , Guo Tianci , Long Yong , Shao Zhongjun 
Published: November 2019

Abstract
Background: Brucellosis is a serious public health problem primarily affecting livestock workers. The strong seasonality of the disease indicates that climatic factors may play important roles in the transmission of the disease. However, the associations between climatic variability and human brucellosis are still poorly understood. Methods: Data for a 14-year series of human brucellosis cases and seven climatic factors were collected in Yulin City from 2005 to 2018, one of the most endemic areas in northern China. Using cross-correlation analysis, the Granger causality test, and a distributed lag non-linear model (DLNM), we assessed the quantitative relationships and exposure-lag-response effects between monthly climatic factors and human brucellosis.Results: A total of 7,103 cases of human brucellosis were reported from 2005 to 2018 in Yulin City with a distinct peak between April and July each year. Seasonal fluctuations in the transmission of human brucellosis were significantly affected by temperature, sunshine duration, and evaporation. The effects of climatic factors were non-linear over the 6-month period, and higher values of these factors usually increased disease incidence. The maximum separate relative risk (RR) was 1.36 (95% confidence interval [CI], 1.03–1.81) at a temperature of 17.4 °C, 1.12 (95% CI, 1.03–1.22) with 311 hours of sunshine, and 1.18 (95% CI, 0.94–1.48) with 314 mm of evaporation. In addition, the effects of these three climatic factors were cumulative, with the highest RRs of 2.27 (95% CI, 1.09–4.57), 1.54 (95% CI, 1.10–2.18), and 1.27 (95% CI, 0.73–2.14), respectively. Conclusions: In Yulin, northern China, variations in climatic factors, especially temperature, sunshine duration, and evaporation, contributed significantly to seasonal fluctuations of human brucellosis within 6 months. The key determinants of brucellosis transmission and the identified complex associations are useful references for developing strategies to reduce the disease burden.
The effectiveness of workplace nutrition and physical activity interventions in improving productivity, work performance and workability: A Systematic Review
Authors: Grimani Aikaterini , Aboagye Emmanuel , Kwak Lydia 
Published: November 2019

Abstract
Background Healthy lifestyles play an important role in the prevention of premature death, chronic diseases, productivity loss and other social and economic concerns. However, worksite interventions to address issues of fitness and nutrition which include work-related outcomes are complex and thus challenging to implement and appropriately measure the effectiveness of. This systematic review investigated the impact of worksite nutrition and physical activity interventions, which include components aimed at worksite’s physical environment and organizational structure, on employees’ productivity, work performance and workability. Methods A systematic review that included randomized controlled trials and or non-randomized controlled studies was conducted. Medline, EMBASE.com, Cochrane Library and Scopus were searched until September 2016. Productivity, absenteeism, presenteeism, work performance and workability were the primary outcomes of our interest, while sedentary behavior and changes in other health-related behaviors were considered as secondary outcomes. Two reviewers independently screened abstracts and full-texts for study eligibility, extracted the data and performed a quality assessment using the Cochrane Collaboration Risk-of-Bias Tool for randomized trials and the Risk-of-Bias in non-randomized studies of interventions. Findings were narratively synthesized. Results Thirty-nine randomized control trials and non-randomized controlled studies were included. Nearly 28% of the included studies were of high quality, while 56% were of medium quality. The studies covered a broad range of multi-level and environmental-level interventions. Fourteen worksite nutrition and physical activity intervention studies yielded statistically significant changes on absenteeism (n=7), work performance (n=2), workability (n=3), productivity (n=1) and on both workability and productivity (n=1). Two studies showed effects on absenteeism only between subgroups. Conclusions The scientific evidence shows that it is possible to influence work-related outcomes, especially absenteeism, positively through health promotion efforts that include components aimed at the workplace’s physical work environment and organizational structure. In order to draw further conclusions regarding work-related outcomes in controlled high-quality studies, long-term follow-up using objective outcomes and/or quality assured questionnaires are required. Registration number PROSPERO CRD42017081837
Towards a Digital Health Curriculum for Health Workforce for the African Region
Authors: Munene Derrick , Alunyu Andrew Egwar , Nabukenya Josephine 
Published: November 2019

Abstract
Background Digital technologies are fast gaining space in health. A skilled workforce is required to use existing and emerging technologies that support healthcare. However, existing medical informatics curriculum from the USA, UK, and African regions reveal gaps in the required competencies for a digital health worker, especially for the African region. Therefore, the aim of this study was to identify the need for and suggest a structure of the digital health curriculum for the African region. Methods The study retrieved articles published in English between 2000 and march of 2019 from PubMed Central, Google Scholar, and Biomedical Central. Only 39 that addressed any form of pre-service and or in-service training of the digital health workers were included in the review. In addition, 8 national ehealth strategies and 13 medical informatics curricula from the USA, UK, and African regions were reviewed to determine the gaps and suggest a structure of the Digital Health curriculum suitable for the African region. Results Many countries in the African region have developed ehealth strategies that clearly highlight the need to train the DH workforce. Results showed knowledge gaps of a communicator, a collaborator, a professional technologist, an advocate, and a manager required of digital health workers in the African region. However, existing digital/health informatics programmes in the region lack balanced course programmes to develop these core competencies. Besides, the corresponding online training is modeled after the traditional face-to-face training, thus limiting the opportunity for in-service health workers. Validation of the Lesotho curriculum confirmed only 10 modules are suitable to develop a rounded digital health worker (particularly health leaders) for the African region. Conclusions Since it is important to develop the competencies consistent with the local health systems to realize the full benefits of ehealth technologies, the African region needs to bridge their human resource gaps. Thus, African countries need to first develop or adopt a digital health worker competency framework and then re-organize their national health training curriculum to ensure a standardized/universal ehealth curriculum for training the digital health workforce. Future works will assess the DH worker competencies and expected outcomes for the African region.
Primary caregivers perceptions of the role of fathers in the provision of nutritional care in a resource constrained environment in Cape Town, South Africa
Authors: Brown Melissa Judith , Roman Nicolette 
Published: November 2019

Abstract
Background : The role of fathers has traditionally been defined as a breadwinner or provider, with men generally having lower levels of engagement in childcare tasks, especially with young children. The involvement of fathers has important consequences for child well-being, especially with regards to issues of diet/nutrition, exercise, play, and parenting behaviours. This paper seeks to explore the perceptions and limitations that primary caregivers have on fathers’ provision of care in a resource constrained community in South Africa.
Methods : Data was collected through in-depth face to face interviews, with a sample of 10 primary caregivers in a resource constrained community in Cape Town, South Africa.
Results : The findings reveal that there is a lack of involvement from fathers in the provision of nutritional care and that this affects mothers and grandmothers who then need to provide both the physical and emotional care to their children. These findings are based on the perspective of mothers and grandmothers and their perceived roles in the family.
Conclusion : The level of lack of financial involvement from fathers has dramatically affected the participating family’s food security due to only one member in the household earning below minimum wage. This has therefore meant that the dietary needs of the family are not being met with nutritional foods, but instead by high fat and high sugar content foods. The findings also highlighted that primary caregivers want to be taught about health and nutritional food choices for a limited budget.
Quality Of Life Questionnaire for women with Gestational Diabetes Mellitus (GDMQ-36): Development and Psychometric Properties
Authors: mokhlesi samira , simbar masoumeh , tehrani fahimeh ramezani , kariman Nourossadat , majd hamid alavi 
Published: November 2019

Abstract
Background Gestational diabetes mellitus carries serious risks to mother and fetus and causes social, mental, and psychological consequences which can affect mothers’ quality of life. Accordingly, this study aims to develop and assess the psychometric properties of quality of life questionnaire for women with gestational diabetes mellitus. Methods A methodological study of sequential exploratory mixed method was developed and implemented. It included qualitative (development of a quality of life questionnaire for mothers with GDM) and quantitative (assessment of psychometric prosperities of quality of life questionnaire for mothers with GDM) phases. Results Based on the findings of the qualitative phase and literature review, the primary questionnaire was prepared with 142 items. The outcome of face validity and content validity assessment was a 67-item questionnaire. S-CVI and S-CVR turned out to be 0.92 and 0.68, respectively. The results of exploratory factor analysis yielded an instrument with 36 items in five domains including concerns about high-risk pregnancy, perceived constraints, disease complications, medication and treatment, and support. Five factors explained 46.68% of the total variance of the questionnaire. The results indicated a moderate and significant correlation between the questionnaire of “Diabetes Clients Quality Of Life” and the researcher-made questionnaire (r=0.63). Cronbach’s alpha coefficient for the entire scale was 0.93 and the intra-class correlation coefficient was 0.95. Conclusion Quality of life questionnaire for mothers with GDM is a valid and reliable tool capable of measuring the quality of life of women with GDM.
Responses of the photosynthetic characteristics and chloroplast ultrastructure of Welsh onion (Allium fistulosum L.) to different LED light qualities
Authors: Gao Song , Liu Xuena , Liu Ying , Cao Bili , Chen Zijing , Xu Kun 
Published: November 2019

Abstract
Background: The optimized illumination of plants using light-emitting diodes (LEDs) is beneficial to their photosynthetic performance. Because of this, in recent years LEDs have been widely used in horticultural facilities. However, there are significant differences in the responses of different crops to light quality. The influence of light quality on photosynthesis needs to be further explored to provide theoretical guidance for the adjustment of the light environment in industrial crop production. This study tested the effects of different qualities of LED lighting (white, W; blue, B; green, G; yellow, Y; and red, R) with the same photon flux density (300 μmol/m2·s) on the growth and development, photosynthesis, chlorophyll fluorescence characteristics, leaf structure, and chloroplast ultrastructure of Welsh onion (Allium fistulosum L.) plants.
Results: The results showed that the plant height, leaf area, and fresh weight of plants in the W and B treatments were significantly higher than those in the other treatments. The photosynthetic pigment content and net photosynthetic rate (Pn) in the W treatment were significantly higher than those in the monochromatic light treatments, while the transpiration rate (E) and stomatal conductance (Gs) were the highest in the B treatment, and the intercellular CO2 concentration (Ci) was the highest in the Y treatment. Among the chlorophyll fluorescence characteristics tested, the non-photochemical quenching coefficient (NPQ) was the highest in the Y treatment, while the maximum photochemical efficiency of photosystem II (PSII) under dark adaptation (Fv/Fm), maximum photochemical efficiency of PSII under light adaptation (Fv'/Fm'), photochemical quenching coefficient (qP), actual photochemical efficiency (ΦPSII), and apparent electron transport rate (ETR) all differed among treatments in the following order: W > B > R > G > Y. Both leaf structure and chloroplast ultrastructure showed the most complete development in the B treatment.
Conclusions: In summary, in addition to W light, B light significantly improved the photosynthetic efficiency of Welsh onion, whereas Y light significantly reduced the photosynthetic efficiency of this plant.
Risk factor analysis for progressive spinal deformity after resection of intracanal tumors─ a retrospective study of 272 cases
Authors: Wang Pangbo , Ma Kang , Chen Tunan , Xue Xingsen , Ma Dada , Wang Shi , Chen Xin , Meng Hui , Cui Gaoyu , Gao Boyuan , Lin Jiangkai , Feng Hua , Chu Weihua 
Published: November 2019

Abstract
OBJECTIVE: Progressive spinal deformity has become a well-recognized complication of intracanal tumors resection. However, the factors affecting post-operative spinal stability remain to be further research. Here, we described the current largest series of risk factors analysis for progressive spinal deformity following resection of intracanal tumors. METHODS: We retrospectively analyzed the medical records of the patients with resection of intracanal tumors between January 2009 and December 2018. All patients who underwent resection of intracanal tumors performed regular postoperative follow-up were identified and included in the study. Clinical, radiological, surgical, histopathological, and follow-up data were collected. The incidence of postoperative progressive kyphosis or scoliosis was calculated. The statistical relationship between postoperative progressive spinal deformity and radiographic, clinical, and surgical variables was assessed by using univariate tests and multivariate logistic regression analysis. RESULTS: Two hundred seventy-two patients (mean age 42.56 ± 16.18 years) with median preoperative modified McCormick score of 3 met the inclusion criteria. Among them, 7（2.6%）patients were found to have spinal deformity preoperatively, and the extent of spinal deformity in these 7 patients deteriorated after surgery. 36 (13.2%) were new cases of postoperative progressive deformity. The mean duration of follow-up was 21.8 months (median 14 months, range 6–114 months). In subsequent multivariate logistic regression analysis, age≤18 years (p=0.027), vertebral levels of tumor involvement (p = 0.019) and preoperative spinal deformity(p=0.008) was the independent risk factors (p < 0.05), increasing the odds of postoperative progressive spinal deformity by 3.94- , 0.69- and 27.11-fold, respectively. CONCLUSIONS: The incidence of postoperative progressive spinal deformity was 15.8%, mostly in these patients who had younger age (≤18 years), tumors involved in multiple segments and preoperative spinal deformity. The risk factors of postoperative progressive spinal deformity warrants serious reconsideration that when performing resection of spinal cord tumors in these patients with such risk factors, the surgeons should consider conducting follow-ups more closely, and when patients suffering from severe symptoms or gradually increased spinal deformity, surgical spinal fusion may be a more suitable choice to reduce the risk of reoperation and improve the prognosis of patients.
Preoperative pelvic floor muscle exercise for early continence after holmium laser enucleation of the prostate: a randomized controlled study
Authors: Anan Go , Kaiho Yasuhiro , Iwamura Hiromichi , Ito Jun , Kohada Yuki , Mikami Jotaro , Sato Makoto 
Published: November 2019

Abstract
Background: Transient postoperative urinary incontinence is a bothersome complication of holmium laser enucleation of the prostate (HoLEP). The effects of preoperative pelvic floor muscle exercise (PFME) for early recovery of continence after HoLEP have never been elucidated. The aim of this study was to determine the benefit of preoperatively started pelvic PFME for early continence recovery after HoLEP. Methods: We randomly assigned patients to start PFME preoperatively and continue postoperatively (group A) or start PFME no earlier than the postoperative period (group B). The primary outcome was time to complete urinary control, defined as no pad usage. The secondary quality of life measure was determined via International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF) scores. Univariate and multivariate analyses were performed to identify parameters associated with recovery of urinary continence after HoLEP. Results: Seventy patients were randomized across groups A (n = 35) and B (n = 35). Patients’ characteristics were not different between groups A and B. The postoperative incontinence rate significantly decreased in group A compared with group B at 3 months postoperatively [3% vs. 26% (P = 0.01)]. However, there were no significant differences between groups A and B at 3 days [40% vs. 54% (P = 0.34)], 1 month [37% vs. 51% (P = 0.34)], and 6 months [0% vs. 3% (P = 1.00)] postoperatively, respectively. The postoperative ICIQ-SF scores were not significantly different between groups A and B at any time point postoperatively. In logistic regression analysis, patients who performed preoperative PFME had a 0.56-fold lower risk of incontinence 1 month after HoLEP and a 0.08-fold lower risk of incontinence 3 months after HoLEP. Conclusions: Preoperatively started PFME appears to facilitate early improvement of urinary incontinence after HoLEP.
Identifying risk factors for perinatal death at Tororo District Hospital, Uganda: a case-control study
Authors: Tesfalul Martha , Natureeba Paul , Day Nathan , Thomas Ochar , Gaw Stephanie L 
Published: November 2019

Abstract
Background Sub-Saharan Africa faces a disproportionate burden of perinatal deaths globally. However, data to inform targeted interventions on an institutional level is lacking, especially in rural settings. The objective of this study is to identify risk factors for perinatal death at a resource-limited hospital in Uganda. Methods This is a retrospective case-control study at a district hospital in eastern Uganda using birth registry data. Cases were admissions with stillbirths at or beyond 24 weeks or neonatal deaths within 28 days of birth. Controls were admissions that resulted in deliveries immediately preceding and following each case. We compared demographic and obstetric factors between cases and controls to identify risk factors for perinatal death. Subgroup analysis of type of perinatal death was also performed. Chi square, Fisher's exact, t-test, and Wilcoxon-Mann-Whitney rank sum tests were utilized for bivariate analysis, and multiple logistic regression for multivariate analysis. Results From January 2014 to December 2014, there were 185 cases of perinatal death, of which 36% (n=69) were macerated stillbirths, 40% (n=76) were fresh stillbirths, and 25% (n=47) were neonatal deaths. The rate of perinatal death among all deliveries at the institution was 35.5 per 1,000 deliveries. Factors associated with increased odds perinatal death included: prematurity (adjusted odds ratio (aOR) 19.7, 95% confidence interval (CI) 7.2-49.2), breech presentation (aOR 7.0, CI 1.4-35.5), multiple gestation (aOR 4.0, CI 1.1 – 13.9), cesarean delivery (aOR 3.8, CI 2.3 – 6.4) and low birth weight (aOR 2.5, CI 1.1-5.3). Analysis by subtype of perinatal death revealed distinct associations with the aforementioned risk factors, in particular for antepartum hemorrhage, which was only associated with fresh stillbirths (aOR 6.7, CI 1.6-28.8), and low birth weight. Conclusions The rate of perinatal death at our rural hospital site was higher than national targets, and these deaths were associated with prematurity, low birth weight, breech presentation, multiple gestation, and cesarean delivery. This data and the approach can be utilized to acquire it can be leveraged to inform targeted interventions to reduce the rate of stillbirths and neonatal deaths in similar low resource settings.