bluuebunny/crossref_metadata_2025_split huggingface dataset:
MESSAGE FRAMING AND ENGAGEMENT IN MENTAL HEALTH CARE: THE MODERATING ROLE OF AGE
Authors: Mavandadi Shahrzad , Wright Erin , Klaus Johanna , Oslin David 
Published: November 2019

Abstract
Engagement rates in specialty mental health (MH) care for depression are suboptimal across the lifespan, prompting various efforts to promote treatment engagement. This study examined the extent to which age moderates the impact of message framing on appointment attendance among patients referred to specialty MH care. The study employed a randomized, prospective, experimental design. Patients meeting criteria for major depression and referred to specialty MH care at a Veterans Affairs Medical Center (n=360) were randomized to receive either a routine, neutrally worded patient reminder letter prior to their scheduled specialty MH care appointment or a letter that included one of two messages (gain-framed or loss-framed) that were added to the routine letter. Appointment/attendance data were extracted from the computerized patient record system. Logistic regression was used to determine the potential moderating effect of age on the association between message frame and appointment attendance. The sample (mean age = 51.5 (SD=13.5)) was primarily male (85%), non-white (62%), and reported an average depressive symptom score of 19.3 (SD=3.8, range=9-27). Age moderated the impact of message frame on the odds of attending the MH appointment: while younger adults were more likely to attend after receiving a gain-framed message, older adults’ engagement rates did not differ significantly across conditions. Findings suggest that overtly highlighting the benefits of attending an initial specialty MH care appointment, even if in writing, can impact engagement rates among younger adults. Potential alternative, targeted approaches utilizing message framing that may be more effective among older adults should be explored.
Identification of Tn Antigen O-GalNAc-expressing glycoproteins in human carcinomas using novel anti-Tn recombinant antibodies
Authors: Matsumoto Yasuyuki , Kudelka Matthew R , Hanes Melinda S , Lehoux Sylvain , Dutta Sucharita , Jones Mark B , Stackhouse Kathryn A , Cervoni Gabrielle E , Heimburg-Molinaro Jamie , Smith David F , Ju Tongzhong , Chaikof Elliot L , Cummings Richard D 
Published: November 2019

Abstract
The Tn antigen is a neoantigen abnormally expressed in many human carcinomas and expression correlates with metastasis and poor survival. To explore its biomarker potential, new antibodies are needed that specifically recognize this antigen in tumors. Here we generated two recombinant antibodies to the Tn antigen, Remab6 as a chimeric human IgG1 antibody and ReBaGs6 as a murine IgM antibody, and characterized their specificities using multiple biochemical and biological approaches. Both Remab6 and ReBaGs6 recognize clustered Tn structures, but most importantly do not recognize glycoforms of human IgA1 that contain potential cross-reactive Tn antigen structures. In flow cytometry and immunofluorescence analyses, Remab6 recognizes human cancer cell lines expressing the Tn antigen, but not their Tn-negative counterparts. In immunohistochemistry (IHC), Remab6 stains many human cancers in tissue array format but rarely stains normal tissues and then mostly intracellularly. We used these antibodies to identify several unique Tn containing glycoproteins in Tn-positive Colo205 cells, indicating their utility for glycoproteomics in future biomarker studies. Thus, recombinant Remab6 and ReBaGs6 are useful for biochemical characterization of cancer cells and IHC of tumors, and represent promising tools for Tn biomarker discovery independently of recognition of IgA1. [191 words].
Bim contributes to the progression of Huntington’s disease-associated phenotypes
Authors: Roberts Sheridan L , Evans Tracey , Yang Yi , Fu Yuhua , Button Robert W , Sipthorpe Rebecca J , Cowan Katrina , Valionyte Evelina , Anichtchik Oleg , Li Huiliang , Lu Boxun , Luo Shouqing 
Published: November 2019

Abstract
Huntington’s disease (HD) is a neurodegenerative disorder caused by an expanded polyglutamine tract in the huntingtin (HTT) protein. Mutant HTT (mHTT) toxicity is caused by its aggregation/oligomerization. The striatum is the most vulnerable region, although all brain regions undergo neuronal degeneration in the disease. Here we show that the levels of Bim, a BH3-only protein, are significantly increased in HD human post-mortem and HD mouse striata, correlating with neuronal death. Bim reduction ameliorates mHTT neurotoxicity in HD cells. In the HD mouse model, heterozygous Bim knockout significantly mitigates mHTT accumulation and neuronal death, ameliorating disease-associated phenotypes and lifespan. Therefore, Bim could contribute to the progression of HD.
EpiMetal: an open-source graphical web browser tool for easy statistical analyses in epidemiology and metabolomics
Authors: Ekholm Jussi , Ohukainen Pauli , Kangas Antti J , Kettunen Johannes , Wang Qin , Karsikas Mari , Khan Anmar A , Kingwell Bronwyn A , Kähönen Mika , Lehtimäki Terho , Raitakari Olli T , Järvelin Marjo-Riitta , Meikle Peter J , Ala-Korpela Mika 
Published: November 2019

Abstract

Motivation
An intuitive graphical interface that allows statistical analyses and visualizations of extensive data without any knowledge of dedicated statistical software or programming.

Implementation
EpiMetal is a single-page web application written in JavaScript, to be used via a modern desktop web browser.

General features
Standard epidemiological analyses and self-organizing maps for data-driven metabolic profiling are included. Multiple extensive datasets with an arbitrary number of continuous and category variables can be integrated with the software. Any snapshot of the analyses can be saved and shared with others via a www-link. We demonstrate the usage of EpiMetal using pilot data with over 500 quantitative molecular measures for each sample as well as in two large-scale epidemiological cohorts (N &gt;10 000).

Availability
The software usage exemplar and the pilot data are open access online at [http://EpiMetal.computationalmedicine.fi]. MIT licensed source code is available at the Github repository at [https://github.com/amergin/epimetal].
Human Plasma BDNF Is Associated With Amygdala-Prefrontal Cortex Functional Connectivity and Problem Drinking Behaviors
Authors: Gorka Stephanie M , Teppen Tara , Radoman Milena , Phan K Luan , Pandey Subhash C 
Published: November 2019

Abstract

Background
Preclinical studies suggest that decreased levels of brain-derived neurotrophic factor in the amygdala play a role in anxiety and alcohol use disorder. The association between brain-derived neurotrophic factor levels and amygdala function in humans with alcohol use disorder is still unclear, although neuroimaging studies have also implicated the amygdala in alcohol use disorder and suggest that alcohol use disorder is associated with disrupted functional connectivity between the amygdala and prefrontal cortex during aversive states.

Methods
The current study investigated whether plasma brain-derived neurotrophic factor levels in individuals with and without alcohol use disorder (n = 57) were associated with individual differences in amygdala reactivity and amygdala-prefrontal cortex functional connectivity during 2 forms of aversive responding captured via functional magnetic resonance imaging: anxiety elicited by unpredictable threat of shock and fear elicited by predictable threat of shock. We also examined whether brain-derived neurotrophic factor and brain function were associated with binge drinking episodes and alcohol use disorder age of onset.

Results
During anxiety, but not fear, lower levels of plasma brain-derived neurotrophic factor were associated with less connectivity between the left amygdala and the medial prefrontal cortex and the inferior frontal gyrus. In addition, within individuals with alcohol use disorder (only), lower levels of brain-derived neurotrophic factor and amygdala-medial prefrontal cortex functional connectivity during anxiety were associated with more binge episodes within the past 60 days and a lower age of alcohol use disorder onset. There were no associations between brain-derived neurotrophic factor levels and focal amygdala task reactivity.

Conclusions
Together, the results indicate that plasma brain-derived neurotrophic factor levels are related to amygdala circuit functioning in humans, particularly during anxiety, and these individual differences may relate to drinking behaviors.
Public health: The voice of professionals
Authors: Ferreira Pedro L , Passadouro Rui 
Published: November 2019

Abstract

Objective
To monitor, for the first time in Portugal, job satisfaction on public health units (PHUs).

Design
Observational, transversal and descriptive/correlational study.

Setting
All 55 PHUs of mainland Portugal.

Participants
This study targeted all 1196 public health professionals working in PHUs.

Main outcome measures
Instrument to Assess Satisfaction of Professionals (IASP), filled online, respecting the ethical considerations and a conceptual measurement model.

Results
Data were obtained from 64% of professionals serving in PHUs, 73% of them female. Response rate of the physicians was 59.1%, with 72.3% of environmental health technicians, 62.0% of nurses and 58.3% of technical assistants. The average age was 47.6(±10.4) years, from 22 to 69 years. We found fair/good satisfaction with men, less educated and professionals with coordination functions more satisfied and low-level satisfaction with salary. Sociodemographic and labour characteristics play a relevant role on job satisfaction. Being female, a physician and an environmental health technician or working in a public setting increases the probability of low satisfaction.

Conclusions
Public health professionals are satisfied with their job, revealing high pride in their professions and strongly recommending their units to family and friends. Some variables, for example gender, leadership, marital status and education, do influence satisfaction. However, we found dissatisfaction among physicians when practice is compared with what is thought in the internship. It is possible to change the reality in which public health professionals work and to contribute to a reorganization of resources, new internal dynamics and establishment of improvement plans, aimed at a full accomplishment and job satisfaction.
Analysing incompliant attitudes towards antibiotic prescription completion in the UK
Authors: Anderson Alistair 
Published: November 2019

Abstract

Objectives
To analyse demographic, social and geographic predictors of incompliant attitudes towards prescription completion in the UK.

Methods
Two waves of the Eurobarometer survey (85.1 and 90.1) were analysed, with a final sample size of 2016. Using logistic regression, the best-fitting combination of a set of identified variables was specified. The regression output and the model-averaged importance of each variable were analysed.

Results
Compared with a median prevalence region, respondents in the Nomenclature of Territorial Units for Statistics (NUTS) 1 London (OR = 2.358, 95% CI = 1.100–5.398) and Scotland (OR = 2.418, 95% CI = 1.083–5.693) regions were most likely to report an incompliant attitude. Respondents who correctly answered questions about whether unnecessary use of antibiotics could make them ineffective in future (OR = 0.353, 95% CI = 0.230–0.544), whether antibiotics kill viruses (OR = 0.644, 95% CI = 0.450–0.919) and whether antibiotics treat colds (OR = 0.412, 95% CI = 0.287–0.591) were less likely to report incompliant attitudes. Conversely, respondents who correctly responded that antibiotics can cause side effects (OR = 1.419, 95% CI = 1.014–1.999) were more likely to report incompliant attitudes. There was some evidence of associations between political orientation and level of compliance. Uncooperative survey respondents (OR = 2.001, 95% CI = 1.108–3.526) were more likely to report incompliant attitudes.

Conclusions
Incompliant attitudes towards antibiotic prescription compliance in the UK are associated with a variety of factors, including regional geographic variation in attitudes. Knowledge about antibiotics can relate to good stewardship attitudes, but concerns over side effects are associated with poor attitudes. Further research should examine the underlying attitudes and beliefs that political orientation may be a marker for in the context of antibiotic stewardship. Survey samples reliant on self-selection are likely to be biased towards good stewardship.
Comparison between IMP carbapenemase-producing Enterobacteriaceae and non-carbapenemase-producing Enterobacteriaceae: a multicentre prospective study of the clinical and molecular epidemiology of carbapenem-resistant Enterobacteriaceae
Authors: Hayakawa Kayoko , Nakano Ryuichi , Hase Ryota , Shimatani Michitsugu , Kato Hideaki , Hasumi Jumpei , Doi Asako , Sekiya Noritaka , Nei Takahito , Okinaka Keiji , Kasahara Kei , Kurai Hanako , Nagashima Maki , Miyoshi-Akiyama Tohru , Kakuta Risako , Yano Hisakazu , Ohmagari Norio 
Published: November 2019

Abstract

Background
Carbapenem-resistant Enterobacteriaceae (CRE) are classified as carbapenemase-producing Enterobacteriaceae (CPE) and non-CPE; the majority of CPE in Japan produce IMP carbapenemase.

Objectives
We evaluated the clinico-epidemiological and microbiological information and effects of IMP-type carbapenemase production in CRE.

Methods
Patients with isolations of CRE (MICs of meropenem ≥2 mg/L, imipenem ≥2 mg/L or cefmetazole ≥64 mg/L) from August 2016 to March 2018 were included. Microbiological analyses and WGS were conducted and clinical parameters were compared between groups. Independent predictors for the isolation of CPE from patients were identified by logistic regression. For comparing clinical outcomes, a stabilized inverse probability weighting method was used to conduct propensity score-adjusted analysis.

Results
Ninety isolates (27 CPE and 63 non-CPE) were collected from 88 patients (25 CPE and 63 non-CPE). All CPE tested positive for IMP carbapenemase. Antibiotic resistance (and the presence of resistance genes) was more frequent in the CPE group than in the non-CPE group. Independent predictors for CPE isolation were residence in a nursing home or long-term care facility, longer prior length of hospital stay (LOS), use of a urinary catheter and/or nasogastric tube, dependent functional status and exposure to carbapenem. Although in-hospital and 30 day mortality rates were similar between the two groups, LOS after CRE isolation was longer in the CPE group.

Conclusions
IMP-CPE were associated with prolonged hospital stays and had different clinical and microbiological characteristics compared with non-CPE. Tailored approaches are necessary for the investigational and public health reporting, and clinical and infection prevention perspectives for IMP-CPE and non-CPE.
Microbiology and Infection Profile of Electric Burned Patients in a Referral Burn Hospital in Mexico City
Authors: López-Jácome Luis Esaú , Chávez-Heres Tatiana , Becerra-Lobato Noé , García-Hernández María de Lourdes , Vanegas-Rodríguez Edgar Samuel , Colin-Castro Claudia Adriana , Hernández-Durán Melissa , Cruz-Arenas Esteban , Cerón-González Guillermo , Cervantes-Hernández Mercedes Isabel , Ortega-Peña Silvestre , Mondragón-Eguiluz Jaime Arturo , Franco-Cendejas Rafael 
Published: November 2019

Abstract
Electrical burn injuries are one of the most severe forms of trauma. This study aims to investigate the infection complications in electrical burn patients in a referral hospital in Mexico City. A longitudinal retrospective study was conducted, involving electrical burn patients admitted from April 2011 to December 2016. Demographic and clinical data including type of electric burns, infection complications, and mortality was sought. Data were collected at admission and daily until discharge. Number and type of infections and microorganism isolations were sought. Risk factors for death were analyzed. A total of 111 patients were included, of which 96.4% were males, mean age of 31.6±16.22, most injuries were high voltage associated. The total body surface area average was 27.8% ± 19.63. The overall infection rate was 72.9 cases per 100 patients. Mortality was observed in 4 (3.6%) patients. About 59.1% (443/749) had growth for Gram-negative bacteria. Multidrug-resistant Pseudomonas aeruginosa was the most frequent microorganism isolated. Fungi were present in 4.9% of cases. Electrical burn injuries occurred in young males in our study. Infection was frequent, most of them caused by Gram-negative rods with an important rate of antimicrobial resistance; however, an important microbial diversity was present.
An Examination of Follow-up Services Received by Vulnerable Burn Populations: A Burn Model System National Database Study
Authors: Benavides Lynne , Shie Vivian , Yee Brennan , Yelvington Miranda , Simko Laura C , Wolfe Audrey E , McMullen Kara , Epp Janelle , Parry Ingrid , Shon Rachel , Holavanahalli Radha , Herndon David , Rosenberg Marta , Rosenberg Laura , Meyer Walter , Gibran Nicole , Wiechman Shelley , Ryan Colleen M , Schneider Jeffrey C 
Published: November 2019

Abstract
While disparities in healthcare outcomes and services for vulnerable populations have been documented, the extent to which vulnerable burn populations demonstrate disparities in long-term care is relatively underexplored. This study’s goal was to assess for differences in long-term occupational or physical therapy (OT/PT) and psychological service use after burn injury in vulnerable populations. Data from the Burn Model System National Database (2006–2015) were analyzed. The vulnerable group included participants in one or more of these categories: 65 years of age or older, nonwhite, no insurance or Medicaid insurance, preinjury receipt of psychological therapy or counseling, preinjury alcohol and/or drug misuse, or with a preexisting disability. Primary outcomes investigated were receipt of OT/PT and psychological services. Secondary outcomes included nine OT/PT subcategories. Outcomes were examined at 6, 12, and 24 months postinjury. One thousand one hundred thirty-six burn survivors (692 vulnerable; 444 nonvulnerable) were included. The vulnerable group was mostly female, unemployed at time of injury, and with smaller burns. Both groups received similar OT/PT and psychological services at all time points. Adjusted regression analyses found that while the groups received similar amounts services, some vulnerable subgroups received significantly more services. Participants 65 years of age or older, who received psychological therapy or counseling prior to injury, and with a preexisting disability received more OT/PT and psychological or peer support services at follow-up. Overall, vulnerable and nonvulnerable groups received comparable OT/PT and psychological services. The importance of long-term care among vulnerable subgroups of the burn population is highlighted by this study. Future work is needed to determine adequate levels of follow-up services.
Machine learning approaches for ELNES/XANES
Authors: Mizoguchi Teruyasu , Kiyohara Shin 
Published: November 2019

Abstract
Materials characterization is indispensable for materials development. In particular, spectroscopy provides atomic configuration, chemical bonding and vibrational information, which are crucial for understanding the mechanism underlying the functions of a material. Despite its importance, the interpretation of spectra using human-driven methods, such as manual comparison of experimental spectra with reference/simulated spectra, is becoming difficult owing to the rapid increase in experimental spectral data. To overcome the limitations of such methods, we develop new data-driven approaches based on machine learning. Specifically, we use hierarchical clustering, a decision tree and a feedforward neural network to investigate the electron energy loss near edge structures (ELNES) spectrum, which is identical to the X-ray absorption near edge structure (XANES) spectrum. Hierarchical clustering and the decision tree are used to interpret and predict ELNES/XANES, while the feedforward neural network is used to obtain hidden information about the material structure and properties from the spectra. Further, we construct a prediction model that is robust against noise by data augmentation. Finally, we apply our method to noisy spectra and predict six properties accurately. In summary, the proposed approaches can pave the way for fast and accurate spectrum interpretation/prediction as well as local measurement of material functions.
Pancreatic solid serous cystadenoma: a rare entity that can lead to a futile surgery
Authors: Demesmaker Vincent , Abou-Messaoud Faouzi , Parent Muriel , Vanhoute Bernard , Maassarani Fadi , Kothonidis Konstantinos 
Published: November 2019

Abstract
Although many types of pancreatic tumors exist, pancreatic solid serous cystadenoma stand as the most rare. Despite advances in medical imaging, definitive diagnosis remains complex. Here, we report a case of a 63-year-old man with a suspicious lesion of the pancreas discovered during a positron emission tomography–computed tomography. Despite an echo-endoscopy being performed, no biopsies were contributive. The magnetic resonance imaging did highlight another lesion in the liver. Due to the suspicion of a neuroendocrine tumor of the pancreas with liver metastases, a cephalic duodenopancreatectomy with partial hepatectomy was performed. During the procedure, another hepatic lesion was resected. The final histological diagnosis was a serous solid adenoma of the pancreas associated with a cholangiocarcinoma. During the follow-up, the patient presented a massive metastatic hepatic relapse even after the administration of a palliative chemotherapy.
The Smile behind the Sales Counter: Soviet Shop Assistants on the Road to Full Communism
Authors: Koenker Diane P 
Published: November 2019

Abstract
This article explores the role of sales assistants in Soviet retail trade in the 1960s, who were overwhelmingly female. It investigates the causes of and remedies for what was widely perceived to be rude and grudging service. Soviet customers and officials felt entitled to a positive consumer experience, and managers and trade union officials agonized over the ways to promote and incentivize “service with a smile.” In addition to the poor performance of Soviet manufacturing, which produced goods that were difficult to sell, other factors included poor training and minimal education, low prestige, and low pay. This article also highlights the continuities in retail sales culture from the 1920s to the 1960s but emphasizes the increasing role assigned to “emotional labor” as important and necessary work by sales workers.
Decidability of affine solution problems
Authors: Hetzl Stefan , Zivota Sebastian 
Published: November 2019

AbstractWe present formula equations—first-order formulas with unknowns standing for predicates—as a general formalism for treating certain questions in logic and computer science, like the Auflösungsproblem and loop invariant generation. In the case of the language of affine terms over $\mathbb{Q}$, we translate a quantifier-free formula equation into an equivalent statement about affine spaces over $\mathbb{Q}$, which can then be decided by an iteration procedure.