bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-sectional association between vitamin B12 status and probable postpartum depression in Indian women
Authors: Dhiman Pooja , Pillai Raji R , Wilson Anand B , Premkumar Nancy , Bharadwaj Balaji , P Veena , Rajendiran Soundravally 
Published: December 2020

Abstract
BackgroundVitamin B12 is an essential micronutrient for neurological function, as it leads to the regeneration of methionine from homocysteine, which is precursor of biologically active molecule S-Adenosyl Methionine (SAM). Pregnancy is a state of increased demand and delayed postpartum repletion of nutrients may predispose women to depression.MethodsWe included women who visited the hospital at 6-weeks postpartum for a regular checkup. Inclusion criteria were age (18 -50 years), and willingness to donate venous sample for analysis. Exclusion criteria included previous history of mood disorders or antidepressant medication use, and any systemic illness like hypothyroidism, epilepsy, diabetes, and hypertension. Based on EPDS score of 10 as a cutoff, 217 women with probable postpartum depression (PPD) and equal number of age and BMI matched controls were included.Plasma total vitamin B12, holotranscobalamin (holotc), homocysteine (hcy), methyl malonic acid (MMA), 5-methyl tetrahydrofolate (THF), SAM and serotonin levels were estimated using commercially available ELISA kits. Combined B12 (cB12) score was calculated from study parameters. Multivariate analysis was performed to assess the risk of probable postpartum depression.ResultsTotal vitamin B12 and combined B12 score were found to be significantly lower (p=0.001) and MMA (p=0.002) and 5-methyl THF (p<0.001) levels were higher in women with probable depression than women without probable PPD. Women in the lowest vitamin B12 quartile had 4.53 times higher likelihood of probable postpartum depression (p < 0.001). Multivariate analysis demonstrated that decreasing vitamin B12 (OR = 0.394; 95% CI: 0.189-0.822) and cB12 (OR=0.293; 95% CI:0182-0.470) and increasing MMA (OR = 2.14; 95% CI: 1.63-2.83) and 5-methyl THF levels (OR = 3.29; 95% CI: 1.59-6.83) were significantly associated with the risk of probable PPD.ConclusionLow vitamin B12 may contribute to depressive symptoms in vulnerable postpartum period.
Family function fully mediates the relationship between social support and depression among antenatal and postpartum women in rural Southwest China
Authors: Huang Yilin , Liu Yan , Wang Yu , Liu Danping 
Published: December 2020

Abstract
Background: Antenatal and postpartum depression is the most common complication of gestation and childbearing affecting women and their families, and good social support and family function are considered the protective and modifiable factors. This study aimed to investigate the depression status and to clarify the interrelationships between social support and depression considering the influence of family function among antenatal and postpartum women in rural areas of Southwest China.Methods: This is a cross-sectional study. Data were collected from a total of 490 rural antenatal (N=249) and postpartum(N=241) women (age: 28.17± 5.12). A structural equation modeling (SEM) was used to test the hypothesized relationships among the variables. The following instruments were used: the Edinburgh Postpartum Depression Scale (EPDS), the APGAR Family Care Index Scale, and the Social Support Rate Scale (SSRS).Results: We found that the prevalence of depression was 10.4%. Path analysis showed that family function had a direct negative correlation with depression (β =-0.251, 95%CI: -0.382 to -0.118). Social support had a direct positive correlation with family function (β =0.293, 95%CI: 0.147 to 0.434) and had an indirect negative correlation with depression (β =-0.074, 95%CI: -0.139 to -0.032), family function fully mediated the relationship between social support and depression. Conclusions: Findings of this study highlight that family function should be considered as the key target for interventions aiming to lower the prevalence of antenatal and postpartum depression. Family members interventions are critical to reduce depression among antenatal and postpartum women.
QTL detection for bread wheat processing quality in a nested association mapping population of semi-wild and domesticated wheat varieties
Authors: Hu Junmei , Xiao Guilian , Jiang Peng , Zhao Yan , Zhang Guangxu , Ma Xin , Yao Jie , Xue Lixia , Su Peisen , Bao Yinguang 
Published: December 2020

Abstract
Background: Wheat processing quality is an important factor in evaluating overall wheat quality, and dough characteristics are important when assessing the processing quality of wheat. As a notable germplasm resource, semi-wild wheat has a key role in the study of wheat processing quality.Results: In this study, four dough rheological characteristics were collected in four environments using a nested association mapping (NAM) population consisting of semi-wild and domesticated wheat varieties to identify quantitative trait loci (QTL) for wheat processing quality. A total of 49 QTL for wheat processing quality were detected, explaining 0.36–10.82% of the phenotypic variation. These QTL were located on all wheat chromosomes except for 2D, 3A, 3D, 6B, 6D and 7D. Compared to previous studies, 29 QTL were newly identified. Four novel QTL, QMlPH-1B.4, QMlPH-3B.4, QWdEm-1B.2 and QWdEm-3B.2, were stably identified in three or more environments, among which QMlPH-3B.4 was a major QTL. Moreover, eight important genetic regions for wheat processing quality were identified on chromosomes 1B, 3B and 4D, which showed pleiotropy for dough characteristics. In addition, out of 49 QTL, 15 favorable alleles came from three semi-wild parents, suggesting that the QTL alleles provided by the semi-wild parent were not utilized in domesticated varieties.Conclusions: The results show that semi-wild wheat varieties can enrich the existing wheat gene pool and provide broader variation resources for wheat genetic research.
Predictive value of clinical toxicities of chemotherapy with fluoropyrimidines and oxaliplatin in colorectal cancer by DPYD and GSTP1 gene polymorphisms
Authors: Deng Xunwei , Hou Jingyuan , Deng Qiaoting , Zhong Zhixiong 
Published: December 2020

Abstract
Background: Fluoropyrimidines and platinum are still widely used for colorectal cancer (CRC) management. Several studies have reported that mutations of dihydropyrimidine dehydrogenase (DPYD) and glutathione S-transferase pi-1 (GSTP1) polymorphisms are related to Chemotherapy-related adverse events. In the present study, we purposed to assess the impact of DPYD and GSTP1 variants on the toxicity of adjuvant chemotherapy risk among the Hakka population, minimize adverse events, and to maximize therapy outcome for individualized treatment.Methods: Genotyping was examined in 104 patients diagnosed with CRC cases and receiving fluoropyrimidine and platinum drugs based chemotherapy regimen by direct sequencing of DPYD and GSTP1 polymorphisms. Three DPYD variants including *2A, *5A, *9A, and GSTP1 c.313A>G were analyzed and clinical outcomes were assessed.Results: The data suggest that the incidence of DPYD*5A, DPYD*9A, and GSTP1 c.313A>G variants were 38.4%, 24%, and 32.7%, respectively. DPYD*2A variant was not found. A total of 23 patients (22.1%) suffered severe vomiting and 19 patients (18.3%) suffered severe anemia. DPYD*5A polymorphism was found significantly associated with grade 3/4 ulceration (p = 0.001). GSTP1 was determined to be an independent risk factor for severe vomiting and skin ulceration (p = 0.042 and p = 0.018, respectively). Patients with GSTP1 c. 313A>G mutant type contributed to a higher risk for grade severe toxicity compared with wild genotype (p = 0.027). Nevertheless, no significant difference was found between patients with DPYD*2A, *5A, *9A for chemotherapeutic toxicity.Conclusions: The results demonstrated that GSTP1 polymorphisms were useful predictors of severe events. Screening of single nucleotide polymorphisms of GSTP1 in colorectal cancer patients before chemotherapy may help to realize personalized therapy.
Improved fuzzy chance-constrained optimization of booster strategy for water distribution system under uncertainty
Authors: Wang Yumin , Zhu Guangcan 
Published: December 2020

Abstract
To sustain water quality in a water distribution system (WDS), disinfectant generally chlorine is boosted to the WDS. However, the concentration of chlorine should be limited to acceptable levels. The upper boundary of the range is set for preventing the occurrence of a disinfectant by-product, which is harmful to human health. The lower boundary of the range is set for controlling the growth of microorganisms as well as reducing the injection mass. As such, an optimization model was applied to solve the water quality issue in a WDS. However, in a WDS, chlorine decays and varies with time and space, affected by pipe material, temperature, pH value, and chlorine injection, etc. Therefore, in this paper, an improved fuzzy chance-constrained optimization model was proposed to optimize chlorine injection and location to maintain chlorine in a WDS distributed uniformly. The proposed model was applied to two WDSs to analyze the effect of reliability level and preference parameters on chlorine injection and location. The results indicated that the injection mass increased with the increase in preference parameter. The results also indicated that more booster stations can lower the injection mass, and two booster stations were suitable for WDS in Case 2. The method proposed can be applied to decide how and where to inject chlorine in a WDS under uncertainty, and can help managers determine whether an optimistic or pessimistic attitude should be taken under various reliability levels.
Kompetencje zawodowe ukraińskich nauczycieli w świetle literatury pedagogicznej drugiej połowy XIX i początku XX wieku
Authors: Yelagina Natalya 
Published: December 2020

W artykule prześledzono rozumienie pojęcia kompetencji zawodowych nauczyciela w ukraińskiej literaturze pedeutologicznej drugiej połowy dziewiętnastego i pierwszej połowy dwudziestego wieku. Analizie poddano wybrane koncepcje kształcenia nauczycieli z tego okresu.
Samodzielne macierzyństwo - wybór czy konieczność?
Authors: Korzeniecka Klaudia 
Published: December 2020

Niniejszy artykuł prezentuje zjawisko samodzielnego macierzyństwa. Opisano w nim dwie grupy samodzielnych matek: tych, które zostały samotnymi rodzicami z konieczności, w wyniku zaistnienia zdarzeń losowych oraz matki, które dokonały świadomego wyboru, aby wychowywać dziecko bez pomocy drugiego rodzica. W pracy zostało przedstawione również samodzielne macierzyństwo z perspektywy realizacji funkcji rodzicielskich. Autorka poruszyła kwestię zaspokojenia potrzeb samodzielnych matek oraz opisała warunki rozwojowe dzieci samotnych matek.
Synthesis, Biological Profile, and Molecular Docking of Some New Bis- Imidazole Fused Templates and Investigation of their Cytotoxic Potential as Anti-tubercular and/or Anticancer Prototypes
Authors: Kassab Refaie M. , Gomha Sobhi M. , Muhammad Zeinab A. , El-khouly Ahmed S. 
Published: December 2020

Background:
There is a great need to discover more drugs with antimycobacterial
activities to fight lung cancer and tuberculosis (two of the deadliest diseases worldwide). To our
knowledge, the present study is the first to report the antimycobacterial activity of imidazole-fused
heterocycles.

Objective:
Construction of some bis-imidazole fused heterocycles with potential anti-tubercular and/or potent antitumor
activities.

Method:
A series of bis-imidazole fused derivatives 6-8 and 13-16 was constructed using bisphenacyl
bromide derivative 2 as a synthetic platform. Compound 2 was also used to access bisquinoxaline
20, bis-benzothiazine derivatives 23, and bis-thiazolopyrimidine derivatives 26. The new
bis-imidazole derivatives were evaluated for their anticancer activity against the lung carcinoma cell
line (A-549) using Cisplatin as a reference drug. The new compounds were also screened for their
anti-tubercular activity against M. tuberculosis (ATCC 25177) using Isoniazid as a reference drug.

Result:
Among the new bis-imidazole derivatives, three examples showed remarkable antitumor
activities while five other compounds showed high antimycobacterial activity.

Conclusion:
A novel series of bis-imidazole fused heterocycles was developed. Multiple prototypes
of this new series showed remarkable anti-tubercular and/or potent antitumor activities.
Efficacy and Cardiovascular Safety of GLP-1 Receptor Analogues
Authors: Iqbal Anoop Mohamed , Imamudeen Nasvin , Basheer Amjad , Menon Sukrita , Mohan Gisha , Sani Tesil Nedumkallel , Haroon Nisha Nigil 
Published: December 2020

Abstract::
Glucagon-like peptide- 1 receptor analogs (GLP-1RAs) are incretin mimetics with potent
glucose-dependent insulinotropic action that translates to glycemic control in people with type-
-2 diabetes mellitus (T2DM). These agents potentially have the ability to stimulate proliferation or
prevent apoptosis of pancreatic β-cells, induce weight-loss and provide vascular benefits in patients
with T2DM. Newer GLP-1RA, semaglutide has shown a robust reduction in HbA1c up to 1.5 -
1.8%. However, individual differences exist between the different GLP-1RAs, in terms of efficacy,
pharmacokinetics, tolerability, and vascular protection. The potential of vascular protection offered
by newer anti-diabetic agents has generated a lot of excitement in the field of diabetes, and to a
large extent, is now driving treatment decisions. So far, six cardiovascular outcome trials of GLP-1
RAs have been published, analyzing lixisenatide (ELIXA), liraglutide (LEADER), semaglutide
(SUSTAIN-6), long-acting exenatide (EXSCEL), dulaglutide (REWIND), and oral semaglutide (PIONEER
6) with a follow-up duration of 2-4 years. LEADER, REWIND and SUSTAIN-6 trials
have demonstrated a reduction in rates of major adverse cardiovascular events with active GLP-1
RA treatment, but ELIXA, PIONEER 6 and EXSCEL, have been neutral. In this review, we discuss
the available evidence from randomized controlled trials (RCTs) analyzing the cardiovascular
effects of various GLP-1 RAs with the aim of comparing individual drugs. We have also summarized
the general aspects of GLP-1RAs that can be applied in clinical practice.
Restless Leg Syndrome in Patients with Liver Cirrhosis! Its Frequency, Severity, and Correlation
Authors: Naqvi Iftikhar Haider , Ahmed Jawad , Salim Maliha , Ubaid Muhammad , Malik Farheen , Afzal Razna , Ashrafi Muhammad Moinuddin , Khan Muhammad Arbaz Arshad 
Published: December 2020

Background:Restless leg syndrome (RLS) has been recognized as a typical additional manifestation among patients with cirrhosis of the liver. RLS prevalence in liver cirrhosis further worsens the quality of life, which has already been compromised with the disease-related complications of cirrhosis itself.Aims:The study aimed to determine the frequency and severity of Restless Leg Syndrome (RLS) among patients with cirrhosis of the liver and to correlate its severity with the severity of cirrhosis.Methods:This prospective cross-sectional study was carried out at Ruth K.M. Pfau Civil Hospital (Karachi, Pakistan) from December 2019 to February 2020. Three hundred and fifteen cirrhotic patients with any etiology were included in the study after informed written consent. Restless leg syndrome with its severity was determined in all cirrhotic patients. For continuous variables, means and medians with standard deviations were calculated, while percentages and proportions were used for discrete variables. Spearman correlation was used to find significance between RLS Severity Score (RSS) and Model of End-stage Liver Disease MELD Score. A p value of < 0.05 was considered significant for all analyses.Results:The frequency of RLS among cirrhotic patients was 38.4%. More than half (54.5%) of the patients had severe RLS. Viral related hepatitis C and hepatitis B were the most common cause of cirrhosis of the liver (57.8% and 30.8%). A significant difference was found between as patients both with or without RLS in terms of age (p=0.003), gender (p=0.005), hemoglobin (p=0.00), and serum albumin (p=0.01). No significant association was found between RLS severity score and MELD Score (p=0.693).Conclusion:Prevalence of RLS is very high among cirrhotic patients, but no correlation was found between the severity of RLS and cirrhosis. Further studies should be carried out to assess the quality of life in cirrhotic patients having RLS.
The Relationship between Life Events and Personality Style to the Development of Depressive and Anxiety Disorders Among Adolescents
Authors: Oschry-Bernstein Noga , Horesh-Reinman Netta , Avnon Adar , Mevorach Tomer , Apter Alan , Fennig Silvana 
Published: December 2020

Background::
The separation of anxiety disorder and depressive disorder as two distinct disorders is often questioned. The aim of the current study is to examine whether there is a different profile of life events and personality characteristics for anxiety and depression disorders in adolescents.

Methods::
One hundred forty-six adolescents participated in the study; 57 boys and 89 girls, ranging in age from 11-18 years (mean=15.08+1.97). The study group included 92 adolescents with a clinical diagnosis of depression or anxiety, and the comparison group included 54 teenagers with no known psychopathology.

Results::
Multinomial logistic regression produced different predictive profiles for anxiety disorder and depressive disorders. Life event variables, especially minor life events and early traumas, were found to be predictors for depression. Furthermore, an interaction was found between early trauma and minor life events in the prediction of depression, such that the existence of trauma weakened the statistical correlation between minor life events and the onset of depression.

:
In addition, contrary to the literature regarding adults, it was found that during adolescence, personality variables have a unique contribution as predictive factors for vulnerability to the onset of anxiety and depression, thus reducing the significance of life events.

Conclusion::
Our findings suggest that different profiles of life events and personality characteristics can be identified for the two disorders. In addition, it appears that early traumas are a dominant factor that overshadow more recent life events at the onset of depression among adolescents.
Shaping Workflows in Digital and Remote Diabetes Care During the COVID-19 Pandemic via Service Design: Prospective, Longitudinal, Open-label Feasibility Trial
Authors: Braune Katarina , Boss Karina , Schmidt-Herzel Jessica , Gajewska Katarzyna Anna , Thieffry Axel , Schulze Lilian , Posern Barbara , Raile Klemens 
Published: December 2020

Background
The COVID-19 pandemic poses new challenges to health care providers and the delivery of continuous care. Although many diabetes technologies, such as insulin pumps and continuous glucose monitors, have been established, the data from these devices are rarely assessed. Furthermore, telemedicine has not been sufficiently integrated into clinical workflows.

Objective
We sought to remotely support children with type 1 diabetes and their caregivers, enhance the clinical outcomes and quality of life of children with diabetes, increase multiple stakeholders’ engagement with digital care via a participatory approach, evaluate the feasibility of using an interoperable open-source platform in a university hospital setting, and analyze the success factors and barriers of transitioning from conventional care to digital care.

Methods
Service design methods were used to adapt clinical workflows. Remote consultations were performed on a monthly and on-demand basis. Diabetes device data were uploaded from patients’ homes to an open-source platform. Clinical and patient-reported outcomes were assessed before, during, and after the COVID-19 lockdown period in Germany.

Results
A total of 28 children with type 1 diabetes and their caregivers enrolled in this study and completed 6 months of remote visits. Of these 28 participants, 16 (57%) also opted to attend at least one of their regular visits remotely. After 3 months of remote visits, participants’ time in range (P=.001) and time in hyperglycemia (P=.004) significantly improved, and their time in hypoglycemia did not increase. These improvements were maintained during the COVID-19 lockdown period (ie, between months 3 and 6 of this study). Participants’ psychosocial health improved after 6 months.

Conclusions
Remote consultations and commonly shared data access can improve the clinical outcomes and quality of life of children with type 1 diabetes, even during challenging circumstances. A service design approach helped with the delivery of comprehensive and holistic solutions that accounted for the needs of multiple stakeholders. Our findings can inform the future integration of digital tools into clinical care during and beyond the pandemic.

Trial Registration
German Clinical Trials Register DRKS00016170; https://tinyurl.com/skz4wdk5
SARS-CoV-2 Testing Service Preferences of Adults in the United States: Discrete Choice Experiment
Authors: Zimba Rebecca , Kulkarni Sarah , Berry Amanda , You William , Mirzayi Chloe , Westmoreland Drew , Parcesepe Angela , Waldron Levi , Rane Madhura , Kochhar Shivani , Robertson McKaylee , Maroko Andrew , Grov Christian , Nash Denis 
Published: December 2020

Background
Ascertaining preferences for SARS-CoV-2 testing and incorporating findings into the design and implementation of strategies for delivering testing services may enhance testing uptake and engagement, a prerequisite to reducing onward transmission.

Objective
This study aims to determine important drivers of decisions to obtain a SARS-CoV-2 test in the context of increasing community transmission.

Methods
We used a discrete choice experiment to assess preferences for SARS-CoV-2 test type, specimen type, testing venue, and results turnaround time. Participants (n=4793) from the US national longitudinal Communities, Households and SARS-CoV-2 Epidemiology (CHASING) COVID Cohort Study completed our online survey from July 30 to September 8, 2020. We estimated the relative importance of testing method attributes and part-worth utilities of attribute levels, and simulated the uptake of an optimized testing scenario relative to the current typical testing scenario of polymerase chain reaction (PCR) via nasopharyngeal swab in a provider’s office or urgent care clinic with results in >5 days.

Results
Test result turnaround time had the highest relative importance (30.4%), followed by test type (28.3%), specimen type (26.2%), and venue (15.0%). In simulations, immediate or same-day test results, both PCR and serology, or oral specimens substantially increased testing uptake over the current typical testing option. Simulated uptake of a hypothetical testing scenario of PCR and serology via a saliva sample at a pharmacy with same-day results was 97.7%, compared to 0.6% for the current typical testing scenario, with 1.8% opting for no test.

Conclusions
Testing strategies that offer both PCR and serology with noninvasive methods and rapid turnaround time would likely have the most uptake and engagement among residents in communities with increasing community transmission of SARS-CoV-2.