bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association of dietary inflammatory index with urinary risk factors of kidney stones formation in men with nephrolithiasis
Authors: Maddahi Niloofarsadat , Yarizadeh Habib , Aghamir SeyedMohammad Kazem , Moddaresi SeyedSaeed , Alizadeh Shahab , Yekaninejad MirSaeed , Mirzaei Khadijeh 
Published: April 2020

Abstract
Objective: Inflammation plays a leading role in the pathogenesis of nephrolithiasis. The association of the dietary inflammatory index (DII) with urinary lithogenic factors is unclear. This study aimed to evaluate the relation of DII to urinary risk factors of kidney stones formation.Results: Of 264 participants, 61.4% (n= 162), 72% (n=190), 74.6% (n=197), 68.6% (n=181), and 80.3% (n=212) had hyperoxaluria, hypercreatininuria, hypercalciuria, hyperuricosuria, hypocitraturia, respectively. There was a significant increasing trajectory in urinary calcium, uric acid, and creatinine as well as a decreasing trend in urinary citrate across tertiles of DII score (all P=≤0.001). After multivariate adjustment for energy intake, age, physical activity and body mass index, high DII scores were associated with elevated odds of having hypercreatininuria (OR=2.80, 95%CI: 1.10-7.12, Ptrend=0.04), hypercalciuria (OR=7.44, 95%CI: 2.62-21.14, Ptrend≤0.001), hyperuricosuria (OR=2.22, 95%CI: 1.001-4.95, Ptrend=0.05), and hypocitraturia (OR=5.84, 95%CI: 2.14-15.91, Ptrend≤0.001). No association was identified between DII and hyperoxaluria.
Significance to investigate the TH1 /TH2 cytokines and their proportions in peripheral blood of women with unexplained recurrent spontaneous abortion and normal women based on pregnancy status
Authors: Peng Yizhi , Wang Min 
Published: April 2020

Abstract
Background: To investigate the significance of th1/th2 cytokines in the pathogenesis of unexplained recurrent spontaneous abortion(URSA) patients. Methods: Flow cytometry was used to determine the level of th1/th2 cytokines in peripheral blood of URSA patients, comparison between two groups was analysed by Mann-Whitney U test, and Kruskal-Wallis H test was used to test three or more groups. Results : T he content of il-6 in peripheral blood of adverse pregnancy group (ad-pregnancy group) was significantly higher than that of URSA group and pregnancy group. The ratio of il-2 / il-4 and IFN-γ/il-4 in peripheral blood of URSA group was significantly higher than that of pregnancy group, the ratio of IFN-γ/il-10 and IFN-γ/il-4 in peripheral blood of ad-pregnancy group was significantly higher than that of pregnancy group. The AUC of IFN-γ/il-4 was 0.821, with high diagnostic efficiency, sensitivity as high as 84.09% and specificity as high as 69.05%, which were higher than other indicators. Conclusion : The Variable of IFN-γ/il-4 can be used for the initial diagnosis of Ursa to reduce the rate of missed diagnosis, the cytokine ratio in the Th1/Th2 immune response was more important than the expression of single cytokine.
How Does Social Support Affect Public Service Motivation of Healthcare Workers: the Mediating Effect of Job Stress
Authors: Deng Jianwei , Guo Yuangeng , Gao Yongchuang , Chen Zhenjiao , Yang Tianan 
Published: April 2020

Abstract
Background: This study examined relations between social support, job stress, and public service motivation, also assessed how social support and job stress affect public service motivation based on the job demands-resources (JD-R) theory. Methods: The survey investigated a sample of 973 healthcare workers employed in public hospitals in Beijing, Xiamen, and Guangzhou in 2017. Through random sampling according to employee number, age and job title, we selected 5% to 10% of healthcare workers in each target hospital. Finally, we got 973 valid participants, and the response rate was 93.8%. We used correlation analysis, structural equation modeling, Sobel test, and subgroup analysis to test by investigating a sample of 973 healthcare workers from 3 Chinese public hospitals. Results: Challenge stress and hindrance stress were directly inversely associated with public service motivation. Supervisor support was significantly positively associated with public service motivation, and the path from coworker support to public service motivation was significant. Supervisor support was significantly negatively associated with hindrance stress, and coworker support was significantly inversely associated with challenge stress. Hindrance stress and challenge stress significantly mediated the relations between supervisor support and public service motivation, and between coworker support and public service motivation respectively. Conclusions: Public service motivation might be raised by increasing supervisor support and coworker support and by limiting hindrance stress and challenge stress among healthcare workers in China.
Painted clay sculpture in Shanxi Province: Material analysis of the Tutang Buddha and two attendants in Jingyin Temple, Taiyuan
Authors: Bai Xiaojian , Jia Chen , Chen Zhigen , Cheng Huwei , Wang Jiayue 
Published: April 2020

Abstract
There are more painted clay sculptures in Shanxi Province than in any other province in China. These fine relics, dating from the Sui and Tang dynasties to the Ming and Qing dynasties, are important to the study of ancient sculpture in China. We investigated the Tutang Buddha (from the Jin dynasty) and two attendant bodhisattvas (from the Ming dynasty) in the Buddha Pavilion of the Jingyin Temple in Taiyuan. The Tutang Buddha was the first clay Buddha in Jinyang (now Taiyuan). According to the inscription, the Tutang Buddha was carved out of the hill. Our onsite investigation revealed that there were coarse and fine layers of clay mixed with wheat straw. It is clear that the construction of the Tutang Buddha is different with the traditional painted clay sculpture. The two attendant bodhisattvas are the traditional painted clay sculptures, which consist of a wood framework covered with layers of coarse clay, fine clay, white ash, paper and pigments. Damaged sections of the painted sculptures were visually examined, sampled and subsequently analysed. All three sculptures have been repainted at least twice. The material samples were analyzed using scanning electron microscopy, energy dispersive spectrometry, Raman spectroscopy, X-ray diffraction, biological microscopy, and particle size analysis. The analysis enabled us to infer the techniques used by the creators of the sculptures. This research provides a foundation for the conservation and future protection of these and similar sculptures.
Evaluation of clinical symptom, laboratory finding and prognosis in thrombotic thrombocytopenic purpura patient from 2010 t0 2017. A single-center retrospective study
Authors: Rostami Mohammad- Reza , Houjaghan Amirmasoud Kazemzadeh , shiraji Sahar Tavakoli , Fumani Hosein Kamranzadeh 
Published: April 2020

Abstract
Background and purpose: thrombotic thrombocytopenic purpura (TTP) is associated with microangiopathic hemolytic anemia, thrombocytopenia, and micro vascular thrombus plus fever, fluctuating neurologic abnormalities and renal damage. The purpose of this study was to investigate clinical symptom, laboratory finding and prognosis in TTP patient from 2010 to 2017 in Shariati hospital. In the present study we assessed clinical presentation and laboratory finding to predict mortality in patients with TTP. Methods: the study was a retrospective cohort study in patient with TTP in Shariati hospital from 2010 to 2017. 114 subjects with TTP after rule out of other microangiopathic hemolytic anemia were included in this study.Results: 114 case of TTP (80 female and 34 male) were identified. Mean ages of participated in the study were 39 years. Hematologic and neurologic symptoms were most common manifestations. Laboratory result at the time of diagnosis revealed mean thrombocytopenia (Plt: 29100), anemia (Hb:8/1), elevated LDH (15100).all patient were treated with PEX, using a cut-off value for the platelet count of 150000/ml. 75% of patient responded . In this study mean of ages, Neurologic manifestation, category of immunologic and reticulocyte count predicted mortality.Conclusion: finally, it can be concluded that mortality rate similar to other study but: in difference clinical symptom and laboratory finding may be predict mortality and occurrence of relapse.
Discoloration of new nanohybrid composites into two different solutions (an invitro study)
Authors: wannous mohammad ali , abboud souad ali 
Published: April 2020

Abstract
Objective: this study aimed to evaluate discoloration of two inorganic nanohybrid composite and an organic modified ceramic resin composite (ormocer) into two solution at different periods of time.Methods: 60 discs of (admira fusion voco, tetric evoceram vivadet ivoclar , tetric N-ceram vivadent ivoclar) were prepared with dimentions of (2mm x 5mm) and devided into three group (A ,B, C) Each group of 20 specimens were randomized into two subgroups, one of them were immersed in coffee and the other in cola for 1, 7, and 28 days of immersion. Color measurements were recorded every time period using Vita Easy shade compact according to the CIE L*a*b* system and results were saved for comparing .The ΔE values between the study time points were calculated. Results: Admira Fusion x-tra showed the lowest ΔE variations (P < 0.01) at all periods of time comparing with Tetric evoceram and Tetric N-ceram at both solution. Coffee caused higher discoloration at all periods of time.Conclusion: Staining beverages caused significant discolorations for all the materials tested. Coffee caused higher discoloration comparing with cola. Nanohybrid ormocer composite reported the lowest color variations.
Effects of Biaxial Ankle Strengthening on Muscle Efficiency during Gait in Chronic Stroke Patients: A Randomized Controlled Pilot Study
Authors: Cho Ji-Eun , Lee Wan-Hee , Shin Joon-Ho , Kim Hogene 
Published: April 2020

Abstract
Background: Ankle dysfunction in stroke patients is a common but serious cause of balance and gait impairment. However there seldom exists comprehensive paretic ankle training. Thus we investigated the effects of biaxial ankle muscle training (AMT) using visual feedback as a means to improve ankle strength and functional activities in stroke patients. Methods: The study design was a randomized controlled pilot trial with concealed allocation and assessor blinding, and intention-to-treat analysis. Twenty-five patients with stroke under inpatient rehabilitation with difficulty walking (e.g. foot drop), or ankle muscle weakness participated. The experimental group underwent AMT consisting of passive stretching, contraction to match movement, and active-resistive strengthening using visual feedback for 40 minutes per day, 5 times per week for 4 weeks. The control group underwent ankle-related physical therapy including ankle range of motion(ROM) exercises for matched time period. The outcomes were ankle isometric contraction force, Fugl-Meyer lower extremity (FM-L), Berg balance scale (BBS), walking speed, and ankle co-contraction index (CI) during gai. Results: The results showed significant between-group differences for ankle isometric contraction in each direction (P<0.05), FM-L (P<0.01) and stance-phase CI (P<0.05). Post training, the AMT group displayed significant differences in the ankle isometric contraction in each direction (P<0.01), ankle proprioception (P<0.05), and walking speed (P<0.05). Conclusions: Our findings demonstrate the significant short-term effects of AMT on ankle strength, walking speed, and ankle muscle efficiency in chronic stroke survivors.
Meta-analysis of AKI to CKD transition in perioperative patients
Authors: Abdala Pedro , Swanson Elizabeth , Hutchens Michael 
Published: April 2020

Abstract
Background Recent research shows AKI increases the risk of incident CKD. We hypothesized that perioperative AKI may confer increased risk of subsequent CKD compared to nonperioperative AKI. Methods A MEDLINE search was performed for “AKI, CKD, chronic renal insufficiency, surgery, and perioperative” and related terms yielded 5209 articles. 1065 relevant studies were reviewed. 1006 were excluded because they were review, animal, or pediatric studies. 59 studies underwent full manuscript review by two independent evaluators. 17 met all inclusion criteria and underwent analysis. Two-by-two tables were constructed from AKI +/- and CKD +/- data. The R package metafor was employed to determine odds ratio (OR) were calculated, and a random-effects model was used to calculate weighted ORs. Leave-1-out, funnel analysis, and structured analysis were used to estimate effects of study heterogeneity and bias. Results Nonperioperative studies included studies of oncology, percutaneous coronary intervention, and myocardial infarction patients. Perioperative studies comprised patients from cardiac surgery, vascular surgery, and burns. There was significant heterogeneity, but ris of bias was overall assessed as low. The OR for AKI versus non-AKI patients developing CKD in all studies was 4.31 (95% CI 3.01-6.17; p < 0.01). Nonperioperative subjects demonstrated OR 3.32 for developing CKD compared to non-AKI patients (95% CI 2.06-5.34; p < 0.01) whilst perioperative patients demonstrated OR 5.20 (95% CI 3.12-8.66; p < 0.01) for the same event. Conclusions We conclude that studies conducted in perioperative and nonperioperative patient populations suggest similar risk of development of CKD after AKI.
A systematic review protocol to explore the prevalence and impacts of neurodevelopmental disorders in the care experienced by the looked after population
Authors: Heady Nicola Jane , Watkins Alan , John Ann , Hutchings Hayley 
Published: April 2020

Abstract
Background: A looked after child (LAC) is defined as a child or young adult, that has been placed in either a foster care, kinship, residential or adoption care setting. While embedded in the care of these services, these children still develop debilitating disorders that significantly impact their future overall wellbeing. Prevalence of these disorders are often depicted under broad, umbrella categories such as mental, behavioural or developmental disorders. What specific disorders fall under these broad categories is limited in research. This review aims to explore the prevalence and early impacts of neurodevelopmental disorders in the LAC and if feasible, compare prevalence with those children who are not looked after (NoN-LAC). Disorders such as dyslexia, bipolar and autism which are classified as neurodevelopmental or associated disorders in the expert field of genetics and neuropsychiatry will be explored. These disorders significantly impact on emotions, memory, ability to learn and socialize and are diagnosed solely based on behaviour. As a result; attaining a diagnosis can take years due to the associated complex behavioural symptomology.With an increasing rate of children entering the care system on a global level; it is an appropriate time to examine the prevalence and impact of these neurodevelopmental disorders in this already, vulnerable population.Methods: A literature search will be conducted using several multiple databases such as PubMed, PsychINFO and Web of Science Core Collection. Secondary literature, grey literature and government publications will also be searched systematically to further identify any eligible studies. Children involved in foster, residential, adopted or kinship care will be identified as a LAC. NoN-LAC will be children who are not placed in the looked after care setting. The age limit is 25 years as the review aims to explore the earlier impacts these disorders may have on the overall wellbeing of these children. Appropriate statistical techniques will be utilised and adapted throughout the review dependent on the research designs of the eligible studies. Discussion: This review could identify gaps in LAC research and potentially contribute to the understanding of the adverse life outcomes that many of these children are predicted to attain. Systematic review registration: PROSPERO Registration number: CRD4201913103
Myeloid Pannexin-1 mediates acute leukocyte infiltration and leads to worse outcomes after brain trauma.
Authors: Seo Joon Ho , Dalal Miloni S. , Calderon Frances , Contreras Jorge 
Published: April 2020

Abstract
Background: Neuroinflammation is a major component of secondary damage after traumatic brain injury (TBI). We recently reported that pharmacological inhibition of Pannexin-1 (Panx1) channels markedly reduced the inflammatory response after TBI. Panx1 channels have been shown to be important conduits for adenosine 5′-triphosphate (ATP) release and are associated with leukocyte infiltration and pyroptosis. Because Panx1 blockers significantly decrease ATP release and migration of activated microglia and other myeloid cells (such as monocyte derived macrophages and dendritic cells) in vitro , we hypothesized that myeloid Panx1 channels play a specific role in immune cell infiltration promoting tissue damage following TBI.Methods: The murine controlled cortical impact (CCI) model was used on myeloid-specific Panx1 conditional knockout ( Cx3cr1 - Cre :: Panx1 fl/fl ) mice to determine whether myeloid Panx1 mediates neuroinflammation and brain damage. Immune cell infiltration was measured using flow cytometry. Locomotor and memory functions were measured using the rotarod and Barnes maze test, respectively. The levels of biomarkers for tissue damage and blood brain barrier leakage were measured using western blot and magnetic resonance imaging. Panx1 channel activity was measured with ex vivo dye uptake assays, using flow cytometry and confocal microscopy.Results: CCI-injured Cx3cr1- Cre ::Panx1 fl/fl mice showed markedly reduced immune cell infiltration to the brain parenchyma compared with Panx1 fl/fl mice. As expected, Panx1 dependent activity, assessed by dye uptake, was markedly reduced only in myeloid cells from Cx3cr1- Cre ::Panx1 fl/fl mice. The expression of biomarkers of tissue damage was significantly reduced in the CCI-injured Cx3cr1- Cre ::Panx1 fl/fl mice compared to Panx1 fl/fl mice. In line with this, magnetic resonance imaging showed reduced blood brain barrier leakage in CCI-injured Cx3cr1- Cre ::Panx1 fl/fl mice. There was also a significant improvement in motor and memory function in Cx3cr1- Cre ::Panx1 fl/fl mice when compare to Panx1 fl/fl mice within a week post-CCI injury.Conclusion: Our data demonstrate that CCI-related outcomes correlate with Panx1 channel function in myeloid cells, indicating that activation of Panx1 channels in myeloid cells is a major contributor to acute brain inflammation following TBI. Importantly, our data indicate myeloid Panx1 channels could serve as an effective therapeutic target to improve outcome after TBI.
Active vibration control of mechanical servo high speed fine-blanking press
Authors: Liu Yan xiong , Shu Yuwen , Hu Wen tao , Zhao Xin hao , Xu Zhi cheng 
Published: April 2020

Abstract
The fine-blanking process as an advanced sheet metal forming process has been widely applied in the industrial area. However, special designed equipment is required for this process. In this paper, a novel mechanical servo high speed fine-blanking press with the capacity of 3200kN is proposed, and the vibration control for this machine is researched to achieve the requirement of fine-blanked parts of high dimensional accuracy, since the vibration of the fine-blanking machine will cause the machining displacement error and reduce the machining accuracy. The self-adaptive feed forward control is used to simulate the active vibration control of the mechanical fine-blanking machine. The vibration control principle of the fine-blanking machine is described and the control algorithm is established. At the same time, the vibration mechanical model of the fine-blanking machine as the controlled object is established, and the parameters of the excitation input and the mechanical model are obtained by the fine-blanking finite element simulation and the experiments of the vibration measurement of the press. Finally, the numerical simulation and analysis of active vibration control based on Matlab are carried out. The results show that the control effect is good, and the vibration response is effectively reduced.
Accelerated molecular breeding of novel cytoplasmic male sterility lines in rice using orfH79 or orf290 haplotypes
Authors: Tan Yanping , Chen Tong , Tian Ze , Li Jiayang , Liu Xuequn , Tang Xianying , Cheng Gang , Xu Xin , Wang Chuntai 
Published: April 2020

Abstract
The identification and development of new cytoplasmic male sterility (CMS) lines in higher plants is important for the preservation of grain security and the prevention of homogenization of hybrid rice. Molecular markers assisted selection (MAS) based on CMS-associated genes or mitochondrial-specific chimeric sequences are important for rapid and effective breeding of new CMS lines and hybrids. In our study, the distribution and allele variation of orfH79 and orf290 genes were characterized from 273 wild and cultivated rice in the AA genome species. Based on the alignment of nucleotide and amino acid sequences, four accessions with orfH79 and three accessions with orf290 were screened. Four novel CMS lines carrying orfH79 haplotypes and three novel CMS lines carrying orf290 haplotypes were then developed using multiple backcross generations with a maintainer line under MAS. The breeding process used in our study provides an efficient and feasible approach for selecting new CMS lines. CMS lines selected in our study are important for enriching rice germplasm resources and guaranteeing rice breeding programs.
IL-17A deficiency alleviate fluoride-induced injury by inhibiting immune response and apoptosis in testis
Authors: Li Yanyan , Zhao Yangfei , Wang Jinming , Cheng Min , Wang Jundong 
Published: April 2020

Abstract
Backgroud Reproductive toxicity of fluoride (F) has been verified by epidemiological and experimental investigations. Based on the literature and our recent studies, as well as the reports inferred by sequencing analysis of mice with normal and fluorosis testes, it is suggested that the interleukin 17A (IL-17A) signaling pathway may be the key link of the damage in testes of the fluorosis animals. To investigate the role of IL-17A in the process of F-induced testicular injury, we exposed wild type (WT) genotype mice and IL-17A knockout (IL-17A-/-) genotype mice to 50mg/L Sodium fluoride (NaF) at 90 days, respectively.Results From the results, we verified IL-17A played a key role in the exacerbation of testicular injuries in fluoride-exposed animals, and found IL-17A knockdown could evidently ameliorate the lesion of testicular damage, including the improves in semen quality,maintain testicular morphology and reducing the immune response in testis. In addition, our results showed that Leydig cells exposed to NaF and recombinant IL-17A in vitro displayed both abnormal apoptoses and decreased secretions of testosterone.Conclusions Altogether, our findings proved that IL-17A deficiency alleviate fluoride-induced injury by inhibiting immune response and apoptosis in testis. This study also provides the mechanism of reproductive toxicity of F, the basis for scientific diagnosis, and possible target drug design.