bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extending the Calgary Audit and Feedback Framework into the virtual environment: a process evaluation and empiric evidence
Authors: Woodhouse Douglas , Duncan Diane , Ferrie Leah , Omodon Onyebuchi , Mehta Ashi , Pokharel Surakshya , Ambasta Anshula 
Published: December 2024

Abstract
Background
The Calgary Audit and Feedback Framework (CAFF) is a pragmatic, evidence-based approach for the design and implementation of in-person social learning interventions using Audit and Group Feedback (AGF). This report describes extension of CAFF into the virtual environment as part of a multifaceted intervention bundle to reduce redundant daily laboratory testing in hospitals. We evaluate the process of extending CAFF in the virtual environment and share resulting evidence of participant engagement with planning for practice change.

Methods
We describe an innovative virtually facilitated AGF intervention based on the CAFF. The AGF intervention was part of an intervention bundle which included individual physician laboratory test utilization reports and educational tools to reduce redundant daily laboratory testing in hospitals. We used data from recorded and transcribed virtual AGF sessions, post AGF session surveys and detailed field notes maintained by project team members. We used simple descriptive statistics for quantitative data and analyzed qualitative data according to the elements of CAFF.

Results
Eighty-three physicians participated over twelve virtual AGF sessions conducted across four tertiary care hospitals during the study period. We demonstrate that all prerequisite activities for CAFF (relationship building, question choice and data representation) were present in every virtual AGF session. Virtual facilitation was effective in supporting the transition of participants through different steps of CAFF in each session to lead to change talk and planning. All participants contributed to discussion during the AGF sessions. The post AGF session surveys were filled by 66% of participants (55/83), with over 90% of respondents reporting that the session helped them improve practice. 46% of participants (38/83) completed personal commitment to change forms at the end of the sessions.

Conclusions
Virtual AGF sessions, developed and implemented with fidelity to the CAFF approach, successfully engaged physicians in a group learning environment that led to change planning. Further studies are needed to determine the generalizability of our findings and to add to the literature on evidence-based virtual facilitation techniques.
Optimizing microgrid integration of renewable energy for sustainable solutions in off/on-grid communities
Authors: Hassan Amal A. , Atia Doaa M. 
Published: December 2024

AbstractRising energy costs, climate change impacts, and transmission losses have increased demand for renewable energy sources and decentralized solutions. As more people seek smart living and working environments, integrated smart microgrids powered by hybrid renewable systems have become attractive solutions for off-grid and on-grid communities. This study proposes designing a solar-wind-battery hybrid microgrid supplying a medical load et al.-Ain Al-Sokhna, Egypt. The optimization objectives aim to minimize the loss of power supply probability (LPSP %) and the levelized cost of energy (LCOE, $/kWh). A key consideration when designing and optimizing hybrid microgrids is the energy management strategy, which coordinates different generation sources and fluctuating load demand. Therefore, optimization algorithms were applied to balance energy flows while meeting loads, mitigating weather impacts, and preventing overcharging/deep discharge of battery storage. Models of wind turbines, photovoltaic panels, and battery storage were developed to simulate and analyze proposed microgrid operations. A multi-objective optimization approach evaluated LPSP and LCOE metrics using transit search, grey wolf, and particle swarm algorithms to find optimal system configurations. The optimization algorithms demonstrated varying performances in minimizing the multi-objective functions for the on-grid and off-grid microgrids. The particle-swarm optimization technique is the best solution for the off-grid system, which contains PV, wind, and battery storage, with a minimum LCOE of 0.3435 $/kWh and an LPSP of 4.5334%. Meanwhile, the transit-search optimization algorithm found the optimal solution for the on-grid configuration according to the objective function, yielding an LCOE of 0.116 $/kWh and an LPSP value of 3.0639 × 10−16. Statistical analysis confirmed that the algorithms generally exhibited stable and robust optimization capabilities. Of the methods, transit search was the most effective overall optimization approach.
Does financial distress impact the dividend payment of Indian firm?
Authors: Agarwal Bhakti , Gautam Rahul Singh , Rastogi Shailesh 
Published: December 2024

Abstract
Purpose
Unexpected circumstances, like distress or bankruptcy, might impact the time or amount of dividends delivered to investors. Therefore, in the current study, we have attempted to reveal the impact of financial distress (FD) on the dividend decisions of firms working in India.

Methodology
In this study, we looked at secondary data from 78 non-finance firms working in different sectors of the Indian economy that had been collected over five years (2016–2020). Panel data analysis (PDA) determines the relationship between the impact of FD and corporate dividend decisions.

Findings
FD has no significant influence on the enterprises' dividend decisions. The association between FD and dividend decisions has also been found to be strongly and positively impacted by one of the interaction variables, environmental, social, and governance.

Limitation
One study constraint is that researchers may choose to conduct their research in different industries or areas. Furthermore, researchers may choose to include other factors as interaction terms that they believe are relevant to the domains of FD or dividends.

Implication
They will be inspired to start effectively managing their finances and debts due to this education. Comprehending these dynamics can aid decision-makers in financial uncertainty and support long-term sustainable value creation for investors, management, and policymakers when making dividend decisions.

Originality
This scholarly work is novel because of the way its variables are combined, especially the way it looks at how four moderators—PBIT, ESG, LII, and debt ratio, interact with one another. To the best of our knowledge, this specific combination has not yet been studied in the literature, which emphasizes the originality of our research.
Tele-rehabilitation in African rural areas: a systematic review
Authors: Oshomoji O. I. , Ajiroba J. O. , Semudara S. O. , Olayemi M. A. 
Published: December 2024

AbstractTele-rehabilitation is a viable method to address healthcare access difficulties in rural parts of Africa. It involves offering remote rehabilitation services using digital technologies. This systematic review assesses the efficacy, implementation obstacles, and technological prerequisites of tele-rehabilitation programs in various environments. Evidence suggests that tele-rehabilitation has a substantial positive impact on patient outcomes, such as enhancing functional recovery and improving quality of life. Additionally, it provides cost-saving advantages by reducing the necessity for travel. Nevertheless, it is important to tackle obstacles such as technological constraints, digital literacy, and data security in order to guarantee the effective execution of the plan. It is essential to have culturally sensitive techniques and comprehensive training for healthcare providers in order to optimize the effectiveness and acceptance of these services. Future studies should prioritize investigating the long-term effects, optimizing the technology used, and integrating tele-rehabilitation programs with current healthcare systems in order to improve their sustainability.Trial registration: PROSPERO CRD42024611266.
Profiling immune cell-related gene features and immunoregulatory ceRNA in ischemic stroke
Authors: Li Yanbo , Liu Sicheng , Wen Linda , Zhang Linzhu , Lei Xue , Zhang Yaguang , Qiu Lei , He Li , Han Junhong 
Published: December 2024

AbstractMolecules in immune cells plays a vital role in the pathogenesis of ischemic stroke (IS). The aim of this study is to profile the landscape of molecules on the basis of immune cells in IS peripheral blood and construct an immunoregulatory competing endogenous RNA (ceRNA) network. We collected and combined multiple public transcriptome datasets from the peripheral blood of IS patients and healthy controls. CIBERSORT deconvolution revealed that the proportions of CD8 and CD4 naive T cells, monocytes, and neutrophils changed significantly in the IS group. Intersecting the immune cell-related genes identified by weighted gene co-expression network analysis (WGCNA) and differential expression analysis, 38 overlapping candidate biomarkers were selected. Three machine learning algorithms, including least absolute shrinkage and selection operator (LASSO), support vector machine-recursive feature elimination (SVM-RFE), and random forest were applied, and 11 distinct immune cell-related genes were identified. We obtained the mRNA-miRNA and miRNA-lncRNA interactions from StarBase v3.0, and constructed a ceRNA network based on the differentially expressed mRNAs, miRNAs, and lncRNAs. The aberrant expression of HECW2-centered ceRNAs in the peripheral blood of in-house patients was validated using quantitative PCR. We also revealed that the expression of HECW2 was positively correlated with lncRNAs LINC02593 through miRNAs miR-130a-3p, miR-130b-3p and miR-148b-3p in cells. These results show that there are distinct immune features between IS patients and healthy controls. The ceRNA network may help elucidate the mechanism of immune cell-related genes in IS and may serve as a therapeutic target.
Analgesic efficacy and safety of erector spinae plane block versus serratus anterior plane block in breast surgery—a meta-analysis and systematic review of randomized controlled trials
Authors: Shaikh Samiullah , Banatwala Umm E Salma Shabbar , Desai Paranshi , Khan Muhammad Arham , Bint-e-Hina Rimsha , Samad Sidra , Sikandari Muhammad Hamza , Nawaz Ali , Ijaz Rana , Asmat Shayan , Fatima Abeer , Mirza Harim , Azam Noor Mahal , Muhammad Qurat Ul Ain , Kumar Satesh , Khatri Mahima 
Published: December 2024

Abstract
Background
Mastectomy and breast-conserving surgery are key interventions for breast cancer, a leading cause of cancer-related mortality in women. Many undergoing breast surgery experience postoperative pain compromising their functionality and quality of life. While multiple pain management strategies are available, evidence comparing the erector spinae (ESPB) and serratus anterior plane blocks (SAPB) for improving post-surgical pain management in breast cancer surgery patients is limited. Therefore, we investigated the efficacy and safety of these two regional anesthesia techniques.

Methods
After PROSPERO registration, we systematically searched PubMed, Google Scholar, and Cochrane Library until May 2024. Risk ratios (RR) were calculated for dichotomous outcomes and standard mean differences (SMD) or mean differences (MD) were computed for continuous data. RevMan Review Manager 5.4.1 was used for the data analysis and generation of forest plots as well as funnel plots. The Cochrane Risk of Bias tool 2.0 (18) and Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) guidelines were used to appraise and evaluate the evidence (19).

Results
A total of 9 randomized control trials enrolling 550 patients were included. Static pain scores at 0, 6, 8, 12, and 24 h after surgery, dynamic pain scores computed at 0, 8, 12, and 24 h after surgery and area under the curve (AUC) static pain score at all time points between 0 and 24 h (SMD (HKSJ 95% CI) − 0.27 [− 0.99, 0.45]) did not significantly vary with either plane block. Postoperative morphine consumption in the first 24 h and the number of patients requesting analgesia were significantly greater in those receiving SAPB [MD: − 1.41 (95% C.I. − 2.70, − 0.13), p = 0.03] and [RR: 1.28 (95% C.I. 1.00, 1.63), p = 0.05], respectively. The time to first postoperative analgesic use was significantly greater among those administered ESPB [MD: 1.55 h, (95% C.I. 1.02, 2.09), p < 0.01]. Patient satisfaction scores and the incidence of nausea and vomiting were similar across both groups.

Conclusions
While pain scores with either block are comparable, ESPB reduces postoperative morphine consumption and may be the favorable option in breast cancer patients undergoing surgery.
Assessment of critically stressed fractures due to water injection — A case study from the Devonian clastic reservoir of the Berkaoui Field, Algeria
Authors: Baouche Rafik , Sen Souvik , Benayad Soumya , Mitra Sourav 
Published: December 2024

A well-constrained geomechanical model of the Devonian clastic is presented to assess the fracture slip potential due to water injection in the Berkaoui field, Algeria. The study interval indicates a strike-slip tectonic regime with a mean maximum horizontal stress azimuth of 98°N. A total of 131 natural fractures are interpreted from acoustic image logs. These fractures have dominantly east–west strikes, with the true dips ranging between 51° and 80° toward north and south. Critically stressed fracture analysis exhibits the onset of the shear displacement of optimally oriented steeply dipping fractures occurring at 2.7 MPa of the injection-induced pressure buildup. The practical injection threshold was inferred as 7 MPa based on the caprock integrity assessment. A total of 10 out of 131 fractures (with dips ≥ 70°) can experience injection-caused slip within the maximum allowable injection limit. The east–west-oriented fractures, subparallel to the maximum horizontal stress azimuth, have a higher likelihood of being critically stressed during injection and, therefore, can contribute to permeability enhancement.
Prescribing of antipsychotics for people diagnosed with severe mental illness in UK primary care 2000–2019: 20-year investigation of who receives treatment, with which agents and at what doses
Authors: Richards-Belle Alvin , Launders Naomi , Hardoon Sarah , Man Kenneth K.C. , Bramon Elvira , Osborn David P.J. , Hayes Joseph F. 
Published: December 2024

Background
Contemporary data relating to antipsychotic prescribing in UK primary care for patients diagnosed with severe mental illness (SMI) are lacking.

Aims
To describe contemporary patterns of antipsychotic prescribing in UK primary care for patients diagnosed with SMI.

Method
Cohort study of patients with an SMI diagnosis (i.e. schizophrenia, bipolar disorder, other non-organic psychoses) first recorded in primary care between 2000 and 2017 derived from Clinical Practice Research Datalink. Patients were considered exposed to antipsychotics if prescribed at least one antipsychotic in primary care between 2000 and 2019. We compared characteristics of patients prescribed and not prescribed antipsychotics; calculated annual prevalence rates for antipsychotic prescribing; and computed average daily antipsychotic doses stratified by patient characteristics.

Results
Of 309 378 patients first diagnosed with an SMI in primary care between 2000 and 2017, 212,618 (68.7%) were prescribed an antipsychotic between 2000 and 2019. Antipsychotic prescribing prevalence was 426 (95% CI, 420–433) per 1000 patients in the year 2000, reaching a peak of 550 (547–553) in 2016, decreasing to 470 (468–473) in 2019. The proportion prescribed antipsychotics was higher among patients diagnosed with schizophrenia (81.0%) than with bipolar disorder (64.6%) and other non-organic psychoses (65.7%). Olanzapine, quetiapine, risperidone and aripiprazole accounted for 78.8% of all antipsychotic prescriptions. Higher mean olanzapine equivalent total daily doses were prescribed to patients with the following characteristics: schizophrenia diagnosis, ethnic minority status, male gender, younger age and greater relative deprivation.

Conclusions
Antipsychotic prescribing is dominated by olanzapine, quetiapine, risperidone and aripiprazole. We identified potential disparities in both the receipt and prescribed doses of antipsychotics across subgroups. To inform efforts to optimise prescribing and ensure equity of care, further research is needed to understand why certain groups are prescribed higher doses and are more likely to be treated with long-acting injectable antipsychotics compared with others.
Massless fermions in black string spacetime
Authors: Darlla R. , Yeşiltaş Ö. , Furtado J. 
Published: December 2024

Abstract
In this paper we investigate the behaviour of massless fermions in the black string spacetime by computing the eigenvalues and eigenfunctions of the Weyl equations. These solutions allowed us to study the behaviour of such massless fermions in terms of the cosmological constant, the black string's mass and the radial distance of the particle from the black string. The solutions, written in terms of parabolic cylinder functions and Laguerre polynomials, were obtained for a particle far from the black string and around the horizon event. For the particle around the event horizon, for all configurations of parameters, the energy eigenvalues are complex-valued, indicating quasi-normal modes similarly to the case of spherical black holes. For the particle far from the black string, the energies derived from the Weyl equation set up conditions on the parameters in order to keep the energy as a real valued parameter.
Evolutionary dynamics with random payoff matrices
Authors: Duong Manh Hong , Han The Anh 
Published: December 2024

Abstract
Uncertainty, characterised by randomness and stochasticity, is ubiquitous in applications of evolutionary game theory across various fields, including biology, economics and social sciences. The uncertainty may arise from various sources such as fluctuating environments, behavioural errors or incomplete information. Incorporating uncertainty into evolutionary models is essential for enhancing their relevance to real-world problems. In this perspective article, we survey the relevant literature on evolutionary dynamics with random payoff matrices, with an emphasis on continuous models. We also pose challenging open problems for future research in this important area.
Renal Function and Risk of Gestational Diabetes Mellitus: The Potential Mediating Role of Carnitine Metabolites
Authors: Yang Xue , Peng Jieru , Sun Fengjiang , Wu Ping , Wang Yi , Xu Ying , Lai Yuwei , Yuan Jiaying , Zhang Shanshan , Jiang Limiao , Hu Yayi , Liu Xiaojuan , Liu Gang , Yang Chunxia , Chen Da , Pan An , Pan Xiong-Fei 
Published: December 2024

Abstract

Context
Renal function may play a crucial role in the development of gestational diabetes mellitus (GDM). However, prospective studies on this topic are scarce and the mechanisms remain unclear.

Objective
This work aimed to assess the associations of early-pregnancy renal function with GDM and the mediating role of carnitine metabolites.

Methods
The study was based on the Tongji-Huaxi-Shuangliu Birth Cohort. Renal function was routinely assessed before 15 gestational weeks. Plasma carnitine metabolites in early pregnancy were quantified using ultrahigh-performance liquid chromatography–tandem mass spectrometry. GDM was diagnosed at 24 to 28 gestational weeks by a 2-hour oral glucose tolerance test. Multivariable logistic regression was used to examine the associations of renal function indicators with GDM. Mediation analyses were applied to assess the mediating effects of carnitines.

Results
The mean age of 6770 participants was 26.6 ± 3.7 years. Serum uric acid, uric acid to creatinine ratio, and estimated glomerular filtration rate (eGFR) were positively associated with GDM, and the odds ratios (95% CIs) were 1.67 (95% CI, 1.25-2.23), 1.94 (1.47-2.57), and 1.53 (1.17-2.01) for the extreme-quartile comparison. Increased creatinine, cystatin C, and creatinine to weight ratio were associated with lower GDM risk, with ORs of 0.62 (0.47-0.82), 0.72 (0.52-0.99), and 0.69 (0.53-0.91) for the extreme-quartile comparison. Serum creatinine-, creatinine to weight ratio-, and eGFR-related carnitine scores played positive mediating roles, and the mediation proportions were 43.1%, 81.9%, and 56.7%, respectively.

Conclusion
Renal function should be monitored for GDM, and the potential roles of carnitine metabolites require further evaluation and validation.
Association Between Delayed/Forgone Medical Care and Resource Utilization Among Women with Breast Cancer in the United States
Authors: Reddy Kriyana P. , Jarrell Kathleen , Berkowitz Cara , Hulse Sarah , Elmore Leisha C. , Fishman Rebecca , Greenup Rachel A. , Mateo Alina M. , Rothman Jami D. , Sataloff Dahlia M. , Tchou Julia C. , Zafar S. Yousuf , Fayanju Oluwadamilola M. 
Published: December 2024

Abstract
Background
Although high treatment costs of breast cancer care are well documented, the relationship between delayed/forgone (D/F) care and resource utilization among patients with breast cancer is unknown. This study sought to investigate the relationship between D/F care, resource use, and healthcare expenditures among patients with breast cancer.

Methods
Data on adult female patients with breast cancer were obtained from the Medical Expenditure Panel Survey to assess resource utilization and expenditures in the United States from 2007 to 2017. Weighted proportions of patients with ≥ 1 emergency department, ≥ 1 inpatient, ≥ 1 outpatient, and > 5 office-based encounters were compared between those experiencing D/F care versus those who did not using Rao-Scott adjusted chi-squared tests. Annual, per capita total, out-of-pocket, emergency department, inpatient, outpatient, office-based visit, and prescription medication expenditures were compared by using two-part econometric models.

Results
Five percent of patients with breast cancer experienced D/F care, and 42.9% of patients cited financial barriers as the primary reason for D/F care. In unweighted estimates, there were higher proportions of patients with ≥ 1 hospitalizations (37% vs. 16%, P < 0.001) among those experiencing D/F care versus those who did not. Patients with D/F care had $5372 (95% CI $35–$10,709, P = 0.04) higher per capita inpatient expenditures than patients without D/F care.

Conclusions
Delayed/forgone care is associated with increased resource utilization and healthcare spending among breast cancer patients. Further work is needed to address the root causes of D/F breast cancer care, with a view to mitigating disparate outcomes and increasing costs.
On Unstable Ground: Trans-Civic, Trans Gender Fluidity in Chester’s ‘Play of the Flood’
Authors: Redfern Gillian 
Published: December 2024

This article explores potential audience reception of the character Uxor in the Chester ‘Play of the Flood’ in relation to the notion of gendered place in medieval Chester. After discussing the implications for divergent readings of Uxor according to cis-centric understandings of place of performance, I interrogate the possibilities of trans places and people in medieval Chester in order to trouble the historically cis approach to Uxor’s performance and potential reception. Ultimately, I posit that Uxor inhabits a trans identity that in a necessarily contingent and temporary way allows trans-Uxor to secure spiritual, if not physical, salvation for those denied access to the ark.