bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of dietary supplementation of beef cows with rumen-protected methionine during the periconceptional period on prenatal growth and performance to weaning
Authors: Heredia Daniella , Tarnonsky Federico , Lopez-Duarte Maria C , Venturini Mauro , Podversich Federico , Ojeda-Rojas Oscar A , Peñagaricano Francisco , Chebel Ricardo C , Luchini Daniel , Hansen Peter J , DiLorenzo Nicolas , Gonella-Diaza Angela M 
Published: December 2024

Abstract
Changes in maternal nutrition during the periconceptional period can influence postnatal growth in cattle. This study aimed to identify the impact of supplementing beef cows with rumen-protected methionine (RP-Met) during the periconceptional period on their female progeny. In experiment 1, plasma methionine (Met) levels were analyzed in samples from 10 Angus crossbred, non-lactating beef cows. Cows were randomly assigned to receive 454 g of cottonseed meal with 15 g/d of RP-Met (RPM; Smartamine M, Adisseo) or not (CON) for 5 d and data were analyzed as a completely randomized design with repeated measures. A treatment-by-day interaction was observed (P &lt; 0.001), where plasma Met concentrations increased in the RPM treatment yet remained basal in CON. In experiment 2, 114 cows were fed a roughage-based diet and randomized to receive 454 g/d of corn gluten supplemented with 15 g/d of RP-Met (RPM n = 56) or not (CON n = 58) from days −7 to 7 relative to timed-artificial insemination using sexed semen to obtain females. Amino acids were measured in plasma samples from days −8, 0, and 7 in cows. In the female progeny, body weight, withers height, body length, and heart girth were measured every 60 d from birth through weaning at an average age of 242 ± 5.8 d. Liver, adipose tissue, and longissimus dorsi muscle biopsies were collected at 187.88 ± 5.5 d of age and a subset of 20 random samples (CON = 10; RPM = 10) were selected for RNA-seq on each tissue. Data were analyzed using a generalized randomized block design with repeated measures. Methionine was increased (P &lt; 0.01) in plasma from cows in the RPM treatment on days 0 and 7. After calving, 34 female calves (CON = 16; RPM = 18) remained in the study and no difference was observed in birth weights between treatments. Calves were taller at the withers for RPM than CON (P = 0.03; CON = 92 ± 1.0 cm; RPM = 95 ± 1 cm) but there were no effects of treatment on other measures of body size. A total of 30, 24, and 2 differentially expressed genes (DEGs; P &lt; 0.01) were observed in liver, longissimus dorsi muscle, and adipose tissue respectively. In summary, feeding RP-Met to cows in the periconceptional period resulted in female calves that were taller than CON before weaning. There were DEGs in the tissue samples but no other changes in measurements associated with body size. In conclusion, supplementation of RP-Met to beef cows during the periconceptional period caused minor changes in the female offspring before weaning.
Drug detection in oral fluid and urine after single therapeutic doses of dexamphetamine, lisdexamphetamine, and methylphenidate in healthy volunteers
Authors: Helland Arne , Muller Sébastien , Spigset Olav , Krabseth Hege-Merete , Hansen Miriam , Skråstad Ragnhild Bergene 
Published: December 2024

Abstract
Dexamphetamine, lisdexamphetamine, and methylphenidate are central stimulant drugs widely used to treat attention-deficit/hyperactivity disorder (ADHD), but poor adherence may lead to treatment failure, and the drugs are also subject to misuse and diversion. Drug analysis in oral fluid may thus be useful for monitoring adherence and misuse. We measured drug concentrations in oral fluid and urine after controlled dosing to investigate detection windows and evaluate the chosen cutoffs. Healthy volunteers ingested single oral doses of 10 mg dexamphetamine (n = 11), 30 mg lisdexamphetamine (n = 11), or 20 mg methylphenidate (n = 10), after which they collected parallel oral fluid and urine samples every 8 h for 4–6 days. Amphetamine (analytical cutoff, oral fluid: 1.5 ng/mL; urine: 50 ng/mL), methylphenidate (oral fluid: 0.06 ng/mL), and ritalinic acid (urine: 500 ng/mL) were analyzed using fully validated chromatographic methods. The median time from ingestion to the last detection in oral fluid was 67 ± 4.9 h (lisdexamphetamine) and 69 ± 8.8 h (dexamphetamine) for amphetamine and 36 ± 2.5 h for methylphenidate. This was comparable to urine (77 ± 5.1 h for lisdexamphetamine, 78 ± 4.5 h for dexamphetamine, and 41 ± 2.4 h for ritalinic acid). The interindividual variability in detection times was large, probably in part due to pH-dependent disposition. Using a logistic regression approach, we found similar detection rates as a function of time since intake in urine and oral fluid with the chosen cutoffs, with a high degree of probability for detection at least 24 h after intake of a low therapeutic dose. This demonstrates the usefulness of oral fluid as a test matrix to assess adherence to ADHD medications, provided that the analytical method is sensitive, requiring a cutoff as low as 0.1 ng/mL for methylphenidate. Detection windows similar to those in urine may be achieved for amphetamine and methylphenidate in oral fluid.
Supernovae evidence for foundational change to cosmological models
Authors: Seifert Antonia , Lane Zachary G , Galoppo Marco , Ridden-Harper Ryan , Wiltshire David L 
Published: December 2024

ABSTRACT
We present a new, cosmologically model-independent, statistical analysis of the Pantheon$+$ Type Ia Supernovae spectroscopic data set, improving a standard methodology adopted by Lane et al. We use the Tripp equation for supernova standardization alone, thereby avoiding any potential correlation in the stretch and colour distributions. We compare the standard homogeneous cosmological model, i.e. spatially flat $\Lambda$ cold dark matter ($\Lambda$CDM), and the timescape cosmology which invokes backreaction of inhomogeneities. Timescape, while statistically homogeneous and isotropic, departs from average Friedmann–Lemaître–Robertson–Walker evolution, and replaces dark energy by kinetic gravitational energy and its gradients, in explaining independent cosmological observations. When considering the entire Pantheon$+$ sample, we find very strong evidence ($\ln B\gt 5$) in favour of timescape over $\Lambda$CDM. Furthermore, even restricting the sample to redshifts beyond any conventional scale of statistical homogeneity, $z \gt 0.075$, timescape is preferred over $\Lambda$CDM with $\ln B\gt 1$. These results provide evidence for a need to revisit the foundations of theoretical and observational cosmology.
AntiBody Sequence Database
Authors: Malesys Simon , Torchet Rachel , Saunier Bertrand , Maillet Nicolas 
Published: December 2024

Abstract
Antibodies play a crucial role in the humoral immune response against health threats, such as viral infections. Although the theoretical number of human immunoglobulins is well over a trillion, the total number of unique antibody protein sequences accessible in databases is much lower than the number found in a single individual. Training AI (Artificial Intelligence) models, for example to assist in developing serodiagnoses or antibody-based therapies, requires building datasets according to strict criteria to include as many standardized antibody sequences as possible. However, the available sequences are scattered across partially redundant databases, making it difficult to compile them into single non-redundant datasets. Here, we introduce ABSD (AntiBody Sequence Database, https://absd.pasteur.cloud), which contains data from major publicly available resources, creating the largest standardized, automatically updated and non-redundant source of public antibody sequences. This user-friendly and open website enables users to generate lists of antibodies based on selected criteria and download the unique sequence pairs of their variable regions.
Navigating Illumina DNA methylation data: biology versus technical artefacts
Authors: Glaser Selina , Kretzmer Helene , Kolassa Iris Tatjana , Schlesner Matthias , Fischer Anja , Fenske Isabell , Siebert Reiner , Ammerpohl Ole 
Published: December 2024

Abstract
Illumina-based BeadChip arrays have revolutionized genome-wide DNA methylation profiling, pushing it into diagnostics. However, comprehensive quality assessment remains challenging within a wide range of available tissue materials and sample preparation methods. This study tackles two critical issues: differentiating between biological effects and technical artefacts in suboptimal quality samples and the impact of the first sample on the Illumina-like normalization algorithm. We introduce three quality control scores based on global DNA methylation distribution (DB-Score), bin distance from copy number variation analysis (BIN-Score) and consistently methylated CpGs (CM-Score) that rely on biological features rather than internal array controls. These scores, designed to be adjustable for different analysis tools and sample cohort characteristics, were explored and benchmarked across independent cohorts. Additionally, we reveal deviations in beta values caused by different sample rankings with the Illumina-like normalization algorithm, verified these with whole-genome methylation sequencing data and showed effects on differential DNA methylation analysis. Our findings underscore the necessity of consistently utilizing a pre-defined normalization sample within the ranking process to boost reproducibility of the Illumina-like normalization algorithm. Overall, our study delivers valuable insights, practical recommendations and R functions designed to enhance reproducibility and quality assurance of DNA methylation analysis, particularly for challenging sample types.
Challenging the narrative of Alport syndrome spectrum: no link with cystic phenotype
Authors: Pagniez Marie-Sophie , Lombardi Yannis , Fages Victor , Larrue Romain , Laboux Timothée , Gatinois Clémence , Letavernier Emmanuel , Rigothier Claire , Glowacki François , Mesnard Laurent , Robert Thomas 
Published: December 2024

ABSTRACT

Background
Alport syndromes (AS) are the second leading genetic cause of kidney failure. Whether the multiple kidney cysts (MKC) phenotype belongs to the AS spectrum remains debated.

Methods
This multicenter retrospective study focused on patients genotyped with pathogenic COL4A3, COL4A4, or COL4A5 variants (classified as ACMG-AMP 4 or 5) between January 2011 and January 2023 across four French university hospitals. The study aimed to compare characteristics between two groups based on the presence or absence of MKC, defined by three or more cysts per kidney. The MKC group was compared to a control group with negative exome sequencing results for undetermined kidney disease (ES-UKD) to assess the association between MKC and AS.

Results
Among the 257 AS patients included, 38 (14.8%) presented MKC without variation from hereditary cystic kidney panel. MKC showed a significant association with male gender (P = 0.004), cardiovascular risk factors, and loss of function variants (P = 0.012). Kidney failure onset appeared significantly later, by 6 years, in MKC patients (P = 0.035). Comparison with the ES-UKD (n = 990) control group showed no significant association between AS and MKC by univariate and multivariate analysis. Multivariate analysis identified patient age and male gender (P &lt; 0.001) as factors linked to MKC.

Conclusions
A 14.8% prevalence of MKC was found in our cohort of 257 patients with AS. MKC-AS patients exhibited clinical and histological characteristics akin to nephroangiosclerosis. Our comprehensive analysis, incorporating a sizable ES-UKD cohort, revealed no significant association between MKC and AS, thus questioning the inclusion of MKC within the spectrum of AS.
The Emergence of Tastes
Authors: Matthen Mohan 
Published: December 2024

Abstract
If the purpose of art is simply to create what is beautiful, it is strange that it takes such different forms in different cultures, and that people generally respond most positively to the artistic products of their own culture. Why are there diverse art forms? I offer a genealogical explanation. In this account, art is culturally coordinated behavior, where culture is a set of shared beliefs transmitted within a community. Culture evolves within local communities by divergence from earlier cultures—this pattern of divergence accounts for diversity. Conversely, if this pattern of divergence is traced backwards in time, we arrive at the ultimate ancestral forms that were the origin of all the local forms we find today. These common ancestors explain why, amidst diversity, there is a degree of cross-cultural commonality and appreciation.
Diversity, Equity, Inclusion, and Belonging
Authors: Starks Saundra H. , Cashwell Suzie T. , Ardrey Saundra Curry 
Published: December 2024

Abstract
Regarding the integration of diversity, equity, inclusion, and belonging (DEIB) in social work practice, rural community strengths are often their liabilities. Rural communities often function in tight-knit groups and have intergenerational connections that perpetuate values and actions that may be counterproductive to DEIB practice. Recent current events have resulted in a call for social work to develop anti-racism strategies and to strengthen DEIB practices. Diversity, equity, inclusion, and belonging are elements that make up the basis for a humane society in which people can grow and thrive. When a segment of society is blocked, then all of society is negatively impacted. Diversity—multiple identities—must include age, race, gender, ethnicity, ability, sexual orientation, religion, political ideology, and the myriad of ways that difference shows up among people. Equity is the redistribution of power and access that enables all people to acquire resources promoting their general welfare. Inclusion ensures all voices, thoughts, ideas, and perspectives are given respect and merit, which is critical to impact the political landscape that requires reshaping for effective DEIB practice. Belonging, which requires a safe space, means that multiple cultures, voices, thoughts, ideas, and perspectives are visible, present, and celebrated. Given the dynamics of rural communities, social workers at all system levels need to find creative ways to enhance DEIB practice. The call for the profession to change the knowledge base, values, and skills to a DEIB lens is now. This chapter explores challenges while presenting several strategies for integrating DEIB practice across systems levels.
Introduction
Authors: Berry Albert 
Published: December 2024

Abstract
Land, the key input for economies in the earlier stages of their development, is the source of much conflict, both physical and political. Its distribution is often highly unequal, typically implying severe inequality of income and welfare, both during development and into the future, as the level of inequality typically manifests a high degree of inertia over time. Explanations for high land concentration vary widely. One argument states that whoever has political, military, or physical power gets the land (or keeps the land). Another theory posits where high concentration exists, it signals the greater efficiency of larger units. This latter perspective has been increasingly contradicted by the evidence that such concentrations typically come with lower total output and a near consensus that it raises inequality.
Land Reform under Communist Regimes
Authors: Berry Albert 
Published: December 2024

Abstract
The land reforms in each of Russia, China, Vietnam, and Cuba occurred after revolutions unseated the traditional ruling group. Vietnam had previously been governed by France and, in Cuba, the US had a major influence. All were highly agricultural at the time of their reforms, except for Cuba. The number of deaths experienced during the revolutions was high in Russia and China, and later deaths were even higher due to Joseph Stalin’s paranoia and brutality in Russia, and in both cases due to serious miscalculations by leaders, which caused food shortages and famine. One initial mistake in all cases was to rely on collective farming of one sort or another, which kept productivity below potential. All four countries eventually pulled back from the collective/cooperative approach and returned operational control to families. In each case, the reform was part of a policy package designed to lower inequality and improve the welfare of the common people; inequality was reduced in all cases, although in the USSR and China it eventually rose again, reaching levels higher than those prior to the revolutions. Vietnam and Cuba have retained their low levels of inequality. Economic growth and poverty reduction were eventually very fast in China and Vietnam, but less so in the USSR and in Cuba, although, in the latter case, poverty was much lower at the time of the reform than in the other three. Vietnam, arguably, underwent the most successful of the four reforms.
The Agreement
Authors: Tannam Etain 
Published: December 2024

Abstract
This chapter sets out the three strands of the 1998 Belfast/Good Friday Agreement and its institutions. The Agreement’s three strands expressed the totality of relations that had permeated British–Irish strategy in Northern Ireland since Charles Haughey’s ‘teapot summit’ with Margaret Thatcher in 1980. The chapter explains how the 1998 Agreement encapsulates John Hume’s approach to resolving conflict in Northern Ireland, addressing three relationships, namely the internal nationalist–unionist relationship in Northern Ireland (Strand One), the cross-border Irish–Northern Irish relationship (North–South) (Strand Two), and the British–Irish relationship as a guardian of the totality of relations and the Agreement itself (Strand Three), and sets out conflicting concepts of sovereignty and interpretations of the Agreement.
Brexit and the European Union
Authors: Tannam Etain 
Published: December 2024

Abstract
This chapter provides an overview of the Brexit negotiations, the Northern Ireland Protocol that was part of its Withdrawal Agreement with the EU, and the tensions caused by it, The impact of Brexit on British–Irish relations cannot be overstated. The chapter highlights its destructive impact on the 1998 Agreement and analyses the role of the EU, the Irish government, and the UK government in the negotiations, where choices by all three at different times and to different degrees may have been ill-judged. The chapter ends by setting out the details of the Windsor Framework, highlighting how it differed from the Protocol, and the restoration of the devolved government in Northern Ireland.
Conclusion
Authors: Tannam Etain 
Published: December 2024

Abstract
This chapter summarises the book’s finding about the successes and failures of the 1998 and Brexit’s impact. In conclusion, it will be shown that, after 2007, the UK and Irish governments’ lack of understanding of the three-strands approach, as well as differences in interpretations of sovereignty, contributed to the Agreement’s weaknesses. The chapter ends by highlighting the salience of identity politics in the context of a referendum on a united Ireland. It emphasises the necessity of institutionalised British–Irish intergovernmental cooperation on the British–Irish Intergovernmental Conference and it recommends returning to the 1985 Intergovernmental Conference as a model to guide the governments about their roles. It also cautions against revising the Agreement.
Community Data
Authors: Bhargava Rahul 
Published: December 2024

Abstract
Community Data offers a new toolkit for data storytelling in community settings, one purpose-built for goals like inclusion, empowerment, and impact. Data visualization has spread into new domains it wasn’t designed for—community organizing, education, journalism, civic governance, and more. The dominant computational methods and processes, which have not changed in response, are causing significant discriminatory and harmful impacts, documented by leading scholars across a variety of populations. Informed by fifteen years of collaborations in academic and professional settings with nonprofits and marginalized populations, Community Data articulates a new approach for aligning the processes and media of data work with social good outcomes, learning from the practices of newspapers, museums, community groups, artists, and libraries. This book introduces a community-driven framework in response to the urgent need to realign data theories and methods around justice and empowerment to avoid further replicating harmful power dynamics and ensure everyone has a seat at the table in data-centered community processes. Community Data offers a broader toolbox for working with data and presenting it, pushing beyond the limited vocabulary of surveys, spreadsheets, charts, and graphs to arts-based practices such as data murals, data sculptures, data theatre, sonification, edibilization, smellification, and beyond.
The rationality of ineffective spin genus-4 theta-null loci
Authors: Zucconi Francesco 
Published: December 2024

ABSTRACT
In this paper we show that the divisor in $S^{+}_g$ given by couples $[C,\theta]$, where C is a curve of genus 4 with a vanishing theta-null and θ is an ineffective theta-characteristic, is a rational variety. Actually we first show that for g = 4, the corresponding theta-null Prym divisor in ${\mathcal{R}}_4$ is rational.
Proper pushforwards on analytic adic spaces
Authors: Abe Tomoyuki , Lazda Christopher 
Published: December 2024

ABSTRACT
We construct proper pushforwards for partially proper morphisms of analytic adic spaces. This generalises the theory due to van der Put in the case of rigid analytic varieties over a non-Archimedean field. For morphisms that are smooth and partially proper in the sense of Kiehl, we furthermore construct the trace map and duality pairing.
Focusing on ligamentous soft tissue inflammation for the future understanding of early axial psoriatic arthritis
Authors: Abacar Kerem , Rennie Winston J , Raychaudhuri Siba P , Chaudhari Abhijit J , McGonagle Dennis 
Published: December 2024

Abstract
Imaging has transformed the understanding of inflammatory and degenerative arthritis in both peripheral and axial disease. In axial inflammation, fat suppression magnetic resonance imaging (MRI) has unravelled the role of sub-fibrocartilaginous osteitis in axial spondyloarthritis and the role of peri-entheseal vertebral body osteitis and subsequent spinal new bone formation. Established or late-stage axial psoriatic arthritis (PsA) cases often exhibit impressive para-marginal or chunky syndesmophytosis on conventional X-ray that pathologically represents entheseal soft tissue ossification. However, the spinal entheseal soft tissue and contiguous ligamentous tissues are poorly visualized on MRI in subjects with early inflammatory back pain including those with axial PsA. In this article, we highlight the need for imaging modalities to discern the crucial soft tissue “ligamentous” component of axial PsA towards diagnosis, prognosis and therapy validation. We issue a clarion call to focus advanced imaging methodology on spinal ligamentous soft tissue that represents the last hidden backwater of PsA immunopathology that needs visualization to fully decipher axial PsA pathogenesis. This in combination with the existing ability to visualize ligamentous bony anchorage site osteitis is needed to define a gold standard test for axial PsA.