bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling of gonioscopic anterior chamber angle grades based on anterior segment optical coherence tomography
Authors: Dai Yingying , Zhang Shaodan , Shen Meixiao , Zhou Yuheng , Wang Mengyi , Ye Jie , Zhu Dexi 
Published: June 2020

AbstractBackgroundTo quantitatively assess anterior chamber angle (ACA) structure by anterior segment optical coherence tomography (AS-OCT) and develop a model to evaluate angle width as defined by gonioscopy.MethodsThe ACAs of each quadrant were evaluated by gonioscopy, classified by the Scheie grading system, and assigned into one of the three grades: small angle (SA), moderate angle (MA), and large angle (LA). The eyes were imaged by AS-OCT, and ACA structural parameters including angle opening distance at the scleral spur (AODSS) and at 750 μm anterior to the scleral spur (AOD750), trabecular-iris space area at 750 μm anterior to the scleral spur (TISA750), and a newly defined parameter “light intersection distance” (LID), were measured. The ACA structural data were used to construct an ordered logistic regression model for assignment of ACAs to one of the three angle grades. The validity of the model was then tested.ResultsA total of 169 quadrants from 53 subjects were included in the analysis, of which 111 quadrants were included in the modeling data and 58 in the testing data. In pairwise comparisons of SA, MA, and LA by ANOVA, the measured parameters were as follows: AOD750 (0.174 ± 0.060 vs. 0.249 ± 0.068 vs. 0.376 ± 0.114 mm;P < 0.001), TISA750 (0.075 ± 0.035 vs. 0.117 ± 0.036 vs. 0.181 ± 0.062 mm2;P < 0.001), and LID (− 0.300 ± 0.187 vs. -0.085 ± 0.170 vs. 0.122 ± 0.156 mm;P < 0.001). The ACA grading model based on LID showed a relatively high correction rate of 72.4%, and the model efficiency, calculated using the receiver operating characteristic, showed an area under the curve of 0.740. Weighted kappa statistics showed a good agreement for multiple ACA grades (0.772).ConclusionsThe AS-OCT-based multiple ACA grades model was demonstrated as a non-contact approach for ACA assessment with high speed and high spatial resolution, providing guidance for diagnosis of angle closure.
Right trisectionectomy for liver metastasis of granulosa cell tumor: a case report and literature review
Authors: Koganezawa Itsuki , Tomita Koichi , Nakagawa Masashi , Ozawa Yosuke , Kobayashi Toshimichi , Sano Toru , Tsutsui Rina , Chiba Naokazu , Okimura Akira , Nakatsugawa Munehide , Hirano Hiroshi , Kawachi Shigeyuki 
Published: June 2020

Abstract
Background
Granulosa cell tumor (GCT) is a type of ovarian sex cord-stromal tumor with low-grade malignancy, which can recur long after primary resection. All reports on GCTs in the liver describe cases of metastases, while there are no previous reports of primary GCTs originating from the liver. We report a case of GCT, with recurrence of liver metastasis long after ovariectomy, which was subsequently resected by a right trisectionectomy.

Case presentation
A 76-year-old woman presented with a history of surgical resection of an ovarian tumor performed 30 years previously; no details of the tumor were available. When she was 68 years old, an abdominal ultrasound revealed a small liver mass, which was diagnosed as a hepatic hemangioma with slow growth. Outpatient follow-up was discontinued for 5 years, and the patient was not examined again until the age of 76 years. At this point, the tumor had substantially increased in size, and surgical resection was required owing to suspicion of malignancy. The patient was then referred to our hospital. Contrast-enhanced computed tomography (CT) showed a large tumor, approximately 18 cm in size, occupying the right lobe and medial section of the liver. After percutaneous transhepatic portal vein embolization, a right trisectionectomy was performed. The histopathological findings of the resected specimen showed that the tumor cells had “coffee bean-like” nuclear grooves, which are characteristic of a GCT. Acidophilic non-structural Call-Exner bodies were also observed. Inhibin-α, CD99, and CD56 markers of sex cord-stromal tumors were detected on immunohistological examination; all pathology suggested a GCT. We considered the tumor to be a liver metastasis of a previous ovarian GCT that was resected 30 years prior by ovariectomy. There was no recurrence for > 15 months after the hepatectomy.

Conclusions
We report a case of a GCT in the liver, which was identified to be a liver metastasis. Right trisectionectomy was subsequently performed for tumor resection. Clinicians should be aware that ovarian GCTs may recur in the liver, and that GCT recurrence may occur long after ovariectomy of the primary ovarian GCT.
Internal hernia of the stomach associated with colostomy after laparoscopic surgery for rectal cancer: a case report
Authors: Hashida Hiroki , Kita Ryosuke , Kondo Masato , Mizuno Ryosuke , Kobayashi Hiroyuki , Kaihara Satoshi 
Published: June 2020

Abstract
Background
Colostomy via the intraperitoneal route is often performed during laparoscopic Hartmann’s operation or abdominoperineal resection. Internal hernia of the small intestine often occurs after colostomy. This report shows a rare case of internal hernia of the stomach associated with sigmoid colostomy after laparoscopic abdominoperineal resection for rectal cancer.

Case presentation
The patient was a 79-year-old woman with a sigmoid colostomy. Computed tomography scan showed a markedly distended stomach in the space between the lifted sigmoid colon and the lateral abdominal wall. Laparoscopy revealed that the body of the stomach had passed through a hernia orifice located between the lifted sigmoid colon and the left lateral abdominal wall. The dislocated stomach was restored to its normal position, and the lateral defect was closed with the lateral peritoneum and the lifted sigmoid colon laparoscopically.

Conclusions
Internal hernia associated with colostomy can lead to not only obstruction of the small intestine, but also obstruction of the stomach. We reported a successful case of the suture repair for the internal hernia of the stomach associated with colostomy.
Temperature integrity and exposure of vaccines to suboptimal temperatures in cold chain devices at different levels in three states of India
Authors: Das Manoja Kumar , Arora Narendra Kumar , Mathew Thomas , Vyas Bhadresh , Devi Salam Kabita , Yadav Abhishek 
Published: June 2020

Abstract
Objective
To document the temperature integrity at the vaccine storage devices at various levels in three states of India.

Methods
A total of 213 health facilities including 196 facilities (district and sub-district levels) from 27 select districts and 17 division or state level vaccine stores in three states were included. At these facilities, temperature in 223 vaccine storage devices was recorded for at least 7 consecutive days using electronic temperature datalogger.

Results
During the observation period, overall the vaccines were exposed to temperature < 0 °C for 14.8% of the storage time with 8.6, 6.7 and 18% at state/division, district and sub-district vaccine stores, respectively. The vaccines were also exposed to temperature > 8 °C for 6.6% of the storage time including 1.3, 13 and 5.1% at state/division, district and sub-district vaccine stores, respectively. Continuous episodes of temperature deviation for 45 min or longer to < 0 °C and > 8 °C was observed in 7.2 and 6.4% of the observation period, respectively. These temperature deviations were not captured by the routine temperature monitoring practice.

Conclusion
The vaccines were exposed to freezing temperature for a considerable period at all level stores, which was more than the exposure to higher temperature. To ensure vaccine potency and immunogenicity, stringent temperature integrity maintenance is needed at all levels.
Opportunities and challenges in providing health care for International Retirement Migrants: a qualitative case study of Canadians travelling to Yuma, Arizona
Authors: Pickering John , Crooks Valorie A. , Snyder Jeremy , Milner Trudie 
Published: June 2020

AbstractBackgroundIncreasing numbers of older individuals opt to spend extended time abroad each year for lifestyle, health, and financial reasons. This practice is known as international retirement migration, and it is particularly popular among retirees in Global North countries such as Canada. Despite the popularity of international retirement migration, very little is known about how and why health care is accessed while abroad, nor the opportunities and challenges posed for destination hospitals. In this article we focus on addressing the latter knowledge gap.MethodsThis qualitative case study is focused on the only hospital in Yuma, Arizona – a popular destination for Canadian retirement migrants in the United States. We conducted focus groups with workers at this hospital to explore their experiences of treating this transnational patient group. Twenty-seven people participated in three, 90-min focus groups: twelve nurses, six physicians, and nine administrators. Thematic analysis of the focus group transcripts was conducted using a triangulated approach.ResultsParticipants identified three care environments: practice, transnational, and community. Each environment presents specific opportunities and challenges pertaining to treating Canadian retirement migrants. Important opportunities include the creation of a strong and diverse seasonal workforce in the hospital, new transnational paths of communication and information sharing for physicians and health administrators, and informal care networks that support formal health care services within and beyond the hospital. These opportunities are balanced out by billing, practical, administrative, and lifestyle-related challenges which add complexity to treating this group of transnational patients.ConclusionCanadians represent a significant group of patients treated in Yuma, Arizona. This is contrary to long-standing, existing research that depicts older Canadians as being reluctant to access care while in the United States. Significant overlaps exist between the opportunities and challenges in the practice, transnational and community environments. More research is needed to better understand if these findings are similar to other destinations popular with Canadian international retirement migrants or if they are unique to Yuma, Arizona.
Determinants of Cycling Performance: a Review of the Dimensions and Features Regulating Performance in Elite Cycling Competitions
Authors: Phillips Kathryn E. , Hopkins William G. 
Published: June 2020

AbstractBackgroundA key tenet of sports performance research is to provide coaches and athletes with information to inform better practice, yet the determinants of athletic performance in actual competition remain an under-examined and under-theorised field. In cycling, the effects of contextual factors, presence of and interaction with opponents, environmental conditions, competition structure and socio-cultural, economic and authoritarian mechanisms on the performance of cyclists are not well understood.ObjectivesTo synthesise published findings on the determinants of cyclists’ behaviours and chances of success in elite competition.MethodsFour academic databases were searched for peer-reviewed articles. A total of 44 original research articles and 12 reviews met the inclusion criteria. Key findings were grouped and used to shape a conceptual framework of the determinants of performance.ResultsThe determinants of cycling performance were grouped into four dimensions: features related to the individual cyclist, tactical features emerging from the inter-personal dynamics between cyclists, strategic features related to competition format and the race environment and global features related to societal and organisational constraints. Interactions between these features were also found to shape cyclists’ behaviours and chances of success.ConclusionTeam managers, coaches, and athletes seeking to improve performance should give attention to features related not only to the individual performer, but also to features of the interpersonal, strategic, global dimensions and their interactions.
Musculoskeletal pain stakeholder engagement and partnership development: determining patient-centered research priorities
Authors: Beneciuk Jason M. , Verstandig Dorothy , Taylor Chuck , Scott Doug , Levin Joan , Osborne Raine , Bialosky Joel E. , Lentz Trevor A. , Buck Tava , Davis Anita L. , Harder Christina , Beneciuk Monika B. , Wittmer Virgil , Sylvester James , Rowe Robert , McInnes David , Fisher Tad P. , McGarrie Lisa 
Published: June 2020

Abstract
Background
Musculoskeletal (MSK) pain is a global public health problem with increased societal burden. Increased attention has focused toward patient and other stakeholder perspectives when determining future MSK pain research priorities, however infrastructure and capacity building within the community are needed for individuals and organizations to participate in patient-centered outcomes research. The purpose of this manuscript is to describe our collaborative experiences with several MSK pain stakeholders and processes to identify a top priority research topic.

Methods
Lunch meetings and formalized workshops were used to develop infrastructure for engaging patients and other stakeholders with early capacity building for partners to identify MSK pain research ideas based on their personal experiences. Additional capacity building and engagement through literature searching further prepared partners to contribute informed decisions about MSK pain research topics and subsequent selection of an important research question.

Results
Several key deliverables (e.g., Governance Document, Communication Plan) were developed and completed over the course of this project to provide partnership structure. Other key deliverables included a list of preliminary comparative effectiveness research ideas (n = 8) and selection of shared decision making for MSK pain as the top priority research topic with patient partners identifying pain self-efficacy as an important outcome domain.

Conclusions
Our patient partners provided the catalyst for identifying shared decision making as a high priority research topic based on a wide spectrum of stakeholder perspectives and unique experiences. Patient partners were primarily identified using a single rehabilitation health system and clinician partners were heavily weighted by physical therapists which may have introduced selection bias.
Telling right from right: the influence of handedness in the mental rotation of hands
Authors: Cheng You , Hegarty Mary , Chrastil Elizabeth R. 
Published: June 2020

Abstract
Background
This study investigated the impact of handedness on a common spatial abilities task, the mental rotation task (MRT). The influence of a right-handed world was contrasted with people’s embodied experience with their own hands by testing both left- and right-handed people on an MRT of right- and left-hand stimuli. An additional consideration is the influence of matching the shape of the hand stimuli with the proprioception of one’s own hands. Two orthogonal hypothesis axes were crossed to yield four competing hypotheses. One axis contrasted (i) embodied experience versus (ii) world knowledge; the other axis contrasted (a) the match between the visual image of a hand on the screen and one’s own hand versus (b) the resemblance of the shape outline information from the hand stimuli with the proprioception of one’s own hands.

Results
Among people with mixed handedness, right-handers performed more accurately for left-hand stimuli, while left-handers had a trend for higher accuracy for right-hand stimuli. For people with extreme handedness, right-handers outperformed left-handers. Regardless of group, there was no significant variation in performance for left-hand stimuli, with only right-hand stimuli producing significant variation.

Conclusions
No hypothesis fully aligned with all the data. For left-hand stimuli, the consistent performance across groups does not provide support for embodied experience, while world knowledge might influence all groups similarly. Alternatively, the within-group variation for mixed-handed people supports embodied experience in the hand MRT, likely processed through visual-proprioceptive integration.
Clinical significance of p27 Kip1 expression in advanced ovarian cancer
Authors: Alrehaili Amani A. , AlMourgi Majed , Gharib Amal F , Elsawy Wael H , Ismail Khadiga Ahmed , Hagag Howaida Mahmoud , Anjum Farah , Raafat Nermin 
Published: June 2020

Abstract
Background
Ovarian cancer is the most common gynecological malignancy. In patients with advanced ovarian cancer, some biological parameters have prognostic implementations. P27kip1 is an inhibitor of a cycline-dependent kinase, its loss, can contribute to tumor progression.

Objective
This study aimed to examine the importance of P27KIP1 protein in predicting the prognosis and response to neoadjuvant chemotherapy in patients with advanced ovarian epithelial cancer and to compare the outcomes of immunohistochemistry with Quantitative Real-time PCR.

Patients and methods
We have studied P27KIP1expression by both immunohistochemistry and Quantitative Real-time PCR from 88 patients with advanced ovarian carcinomas undergone radical debulking surgery and received Paclitaxel followed by Cisplatin every 3 weeks for a total of 6 cycles. We also studied their association with both chemotherapy response and patient survival.

Results
Nuclear expression of p27KIP1 protein was intense in 86 normal ovarian tissues and 42 of 88 carcinomas. The P27kip1mRNA expression level by qRT-PCR was very low in ovarian cancer tissues relative to its adjacent normal tissues. The results were statistically significant by both methods of determination. p27KIP1 expression was significantly related to good prognostic parameters as low stage tumors, differentiated tumors, absence of ascites, residual disease < 2 cm, and response to chemotherapy but not with histopathological type in case of determination by immunohistochemistry. Comparison of P27kip1 by both immunohistochemistry and qRT-PCR with different prognostic parameters revealed no significant difference between both methods in the assessment of these parameters. In 4 years of follow-up, 20.5% of patients were alive without evidence of disease. 6.8% were alive with disease. The disease-related four -year survival rate for the whole group was 28.2%. In multivariate analysis, residual disease, histological type, tumor differentiation, ascites was of independent prognostic significance.

Conclusion
In ovarian cancer, patients with loss of p27KIP1 expression are at a greater likelihood of disease progression, p27KIP1 may be used as a molecular marker to predict response to chemotherapy and prognosis. Both immunohistochemistry and qRT-PCR have equal reliability in the determination of p27 KIP1.
Antiplasmodial activities of Morinda lucida (Benth) and Alstonia boonei (De wild) in mice infected with Plasmodium berghei
Authors: Afolabi Olajide Joseph , Abejide Adekemi Eunice 
Published: June 2020

Abstract
Background
This study focused on the antiplasmodial activities of two botanicals: Morinda lucida and Alstonia boonei used in malaria treatment. The in vivo activity of the plants against established Plasmodium berghei NK65 infection was evaluated in 75 experimental mice randomly distributed into 15 groups and treated with extracts of M. lucida and A. boonei, combined recipe of the two plants at graded doses of 400, 600, and 800 mg/kg and chloroquine at 10 mg/kg.

Results
The results revealed that the percentage parasitemia was higher in the infected untreated mice (18.40%) than the treated mice. Among the treated mice, the highest percentage parasitemia (6.0%) was obtained in mice treated with 800 mg/kg of A. boonei while the lowest percentage parasitemia (0.0%) was obtained in mice treated with 10 mg/kg of chloroquine. Chloroquine eliminated all the parasites (100% clearance) when compared to the percentage clearance by the plant extracts. For the plant extracts, antiplasmodial activity was highest with the combined recipe of M. lucida and A. boonei at 800 mg/kg (92%) and lowest at 800 mg/kg (45%) of M. lucida. Meanwhile, the optimal antiplasmodial activity (83%) of M. lucida was obtained at 400 mg/kg and that of A. boonei was obtained at 600 mg/kg (85%).

Conclusions
This study revealed that the two plant extracts under the study have antiplasmodial activities which are promising in reducing the morbidity and mortality of drug-resistant malaria in endemic communities.
History, ethnicity, and policy analysis of organic farming in Japan: when “nature” was detached from organic
Authors: Miyake Yoshitaka , Kohsaka Ryo 
Published: June 2020

AbstractThe ratio of organic farming in Japan stagnated in terms of area and involved farmers despite the richness in history symbolized in terms such as the Fukuoka methods or the more recentTeikei. This paper first reviews the historical development of Japan’s organic agriculture from the 1930s (first epoch), regarding Japanese ethnicity and its roots and relationships to nature. Based on this analysis, we critically evaluate policy development from the 1990s (second epoch). Here, we provide potential explanation for the low ratio of organic agriculture in Japan. By combing the conceptual analysis of ethnicity and organic movements, the underpinning factors that underlie the development of organic farming are analyzed both from historical and cultural contexts. Natural farming is a separate individual practice in Japan, with its own philosophical backgrounds. This initial 1930s terminology of “natural farming” or shizen nōhō (自然農法) was translated into yūki nōgyō (有機農業) in the 1970s. This review claims that the meaning of organic agriculture got too narrow to promote organic agriculture with the governmental intervention and standardization from the 1990s. The initial phase of yūki nōgyō also had such a problem as the concept became increasingly institutionalized through government standardization and policy from the 1990s. Currently, at the conceptual level, the linkage to nature, i.e., “shizen,” is confined into “non-use of chemical components” through formal institutionalization, and the ethnic elements or philosophical and historical roots are neglected. Similar phenomena of “commodification of organic farming” are widely known in matured markets in the USA and Europe, but the discrepancy of “nature” and “organic” agriculture is particularly also observed in contemporary Japan.