bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gene dysregulation analysis builds a mechanistic signature for prognosis and therapeutic benefit in colorectal cancer
Authors: Li Quanxue , Dai Wentao , Liu Jixiang , Sang Qingqing , Li Yi-Xue , Li Yuan-Yuan 
Published: July 2020

Abstract
The implementation of cancer precision medicine requires biomarkers or signatures for predicting prognosis and therapeutic benefits. Most of current efforts in this field are paying much more attention to predictive accuracy than to molecular mechanistic interpretability. Mechanism-driven strategy has recently emerged, aiming to build signatures with both predictive power and explanatory power. Driven by this strategy, we developed a robust gene dysregulation analysis framework with machine learning algorithms, which is capable of exploring gene dysregulations underlying carcinogenesis from high-dimensional data with cooperativity and synergy between regulators and several other transcriptional regulation rules taken into consideration. We then applied the framework to a colorectal cancer (CRC) cohort from The Cancer Genome Atlas. The identified CRC-related dysregulations significantly covered known carcinogenic processes and exhibited good prognostic effect. By choosing dysregulations with greedy strategy, we built a four-dysregulation (4-DysReg) signature, which has the capability of predicting prognosis and adjuvant chemotherapy benefit. 4-DysReg has the potential to explain carcinogenesis in terms of dysfunctional transcriptional regulation. These results demonstrate that our gene dysregulation analysis framework could be used to develop predictive signature with mechanistic interpretability for cancer precision medicine, and furthermore, elucidate the mechanisms of carcinogenesis.
Seasonal Fluctuations in Sarcophagidae (Diptera: Calyptratae) Assemblages in the Humid Chaco Ecoregion, Argentina
Authors: Dufek Matias I , Damborsky Miryam P , Mulieri Pablo R 
Published: July 2020

AbstractThe seasonal fluctuations of flesh fly (Diptera: Sarcophagidae) assemblages were investigated from March 2015 to February 2016 in five habitat types in the Humid Chaco ecoregion, Chaco Province, Argentina. Three of the habitats were anthropized: an urban area, a cattle farm, and an alfalfa crop; and two were natural: a savanna and a forest. Flesh flies were collected monthly at 25 sampling points, five per habitat. In total, 5,790 male specimens comprising 55 species distributed in 15 genera were collected. The assemblage composition of flesh flies in each habitat and season was analyzed in terms of abundance, species richness, and diversity. In addition, the correlation between these community parameters and climatic factors (precipitation 7 and 14 d before samplings, temperature, and relative humidity) were evaluated in each habitat. The highest abundance and species richness of Sarcophagidae were registered in May (autumn) and June (winter), respectively. The lowest diversity values were observed between August and September (end of winter and early spring) in all habitats. However, flesh flies were present and well represented (in terms of species richness) throughout the year in all habitat types. Fluctuations in the abundance of the most abundant species collected were analyzed. The climatic factors were correlated with diversity and species richness in the urban, cattle farm, and savanna habitats. This study revealed that flesh fly assemblages differed temporally between different types of habitats in accordance with climatic factors and microclimate conditions.
Rethinking Categories and Dimensions in the DSM
Authors: Phillips James 
Published: July 2020

AbstractThis paper addresses the role of categories and dimensions in the classification of psychopathology. While psychopathology does not sort itself out neatly into natural categories, we do find rough, symptom-based groupings that, through refinement, become diagnostic categories. Given that these categories suffer from comorbidity, uncertain boundaries, and excessive “unspecified disorder” diagnoses, there has been a move toward refining the diagnoses with dimensional measures. The paper traces efforts both to improve the diagnostic categories with validators that allow at least partial validity and to introduce dimensional measures into the diagnostic manual. Drawing from the philosophical pragmatism of Charles Sanders Peirce, William James, and John Dewey, which emphasizes the practical, effect-sensitive consequences of a theory along with an emphasis on empirical evidence and the progressive, probabilistic character of knowledge, the paper argues that these efforts must be guided both by scientific validity and clinical utility.
Reporting of methodologies used for clonogenic assays to determine radiosensitivity
Authors: Oike Takahiro , Komatsu Shuichiro , Komatsu Yuka , Nachankar Ankita , Darwis Narisa Dewi Maulany , Shibata Atsushi , Ohno Tatsuya 
Published: July 2020

Abstract
Radiotherapy treatment strategies should be personalized based on the radiosensitivity of individual tumors. Clonogenic assays are the gold standard method for in vitro assessment of radiosensitivity. Reproducibility is the critical factor for scientific rigor; however, this is reduced by insufficient reporting of methodologies. In reality, the reporting standards of methodologies pertaining to clonogenic assays remain unclear. To address this, we performed a literature search and qualitative analysis of the reporting of methodologies pertaining to clonogenic assays. A comprehensive literature review identified 1672 papers that report the radiosensitivity of human cancer cells based on clonogenic assays. From the identified papers, important experimental parameters (i.e. number of biological replicates, technical replicates, radiation source and dose rate) were recorded and analyzed. We found that, among the studies, (i) 30.5% did not report biological or technical replicates; (ii) 47.0% did not use biological or technical replicates; (iii) 3.8% did not report the radiation source; and (iv) 32.3% did not report the dose rate. These data suggest that reporting of methodologies pertaining to clonogenic assays in a considerable number of previously published studies is insufficient, thereby threatening reproducibility. This highlights the need to raise awareness of standardization of the methodologies used to conduct clonogenic assays.
Extended right posterior liver sectionectomy for HCC in a patient with left ventricular assist device—a case report
Authors: Timmermann Lea , Schmelzle Moritz , Potapov Evgenij , Müller Marcus , Lojewski Christian , Pratschke Johann , Schöning Wenzel 
Published: July 2020

Abstract
Successful implementation of left ventricular assist devices lead to a prolonged survival in patients with chronic terminal heart failure. Thus, patients with pre-existing left ventricular assist devices with abdominal comorbidities requiring abdominal surgery, e.g. for malignancy, are upcoming issues. We carried out a major liver resection for hepatocellular carcinoma in a patient with pre-existing left ventricular assist device. The importance of this case report is that it outlines the significance of oncologic resections in patients with left ventricular assist devices as an upcoming issue and provides an interdisciplinary approach.
Preoperative embolization of high-flow peripheral AVMs using plug and push technique with low-density NBCA/Lipiodol
Authors: Ho Anh Binh , Nguyen Ngoc Son , Le Vu Huynh , Nguyen Duc Dung , Phan Anh Khoa , Nguyen Thanh Xuan , Pham Nhu Hiep 
Published: July 2020

Abstract
Arteriovenous malformations (AVMs) embolization is considered as a promising option either its single treatment or in combination with surgery, and the use of low-density N-butyl cyanoacrylate (NBCA)/Lipiodol is acceptable mixture agents but its application should be performed by experienced endovascular teams. We describe a successful case preoperative embolization of high-flow AVMs with low-density NBCA/Lipiodol. A 26-year-old male patient was hospitalized with a big pulsatile mass at the right thigh. Doppler ultrasound showed a mass with high systolic, and diastolic velocities coming from the right superficial femoral artery. Angiogram showed a large and high-flow AVM type IV, according to Yakes classification. Low-density NBCA/Lipiodol 12.5% were performed to obstruct all the nidus and feeding arteries. Extirpation surgery was implemented 4 days after the complete embolization procedure.
Are patients with cognitive impairment fit to fly? Current evidence and practical recommendations
Authors: Sadlon Angélique , Ensslin Angela , Freystätter Gregor , Gagesch Michael , Bischoff-Ferrari Heike A 
Published: July 2020

Abstract

Background
The worldwide prevalence of dementia is increasing and represents a major public health concern. In the last decades, air travel services have undergone an impressive expansion and one of ten passengers is aged 65 years and older. While air travel can be stressful at all ages and health conditions, older individuals with cognitive impairment carry a greater risk for air-travel-related complications. Consequently, demands to general practitioners for assessing their older patient’s fitness to fly are increasing.

Methods
We conducted a search of the literature in PubMed on the impact of in-flight environmental changes on passengers with cognitive impairment and possible resulting complications. This set the base for a discussion on pharmacological and non-pharmacological interventions aimed at preventing in-flight complications in this vulnerable population.

Results
While our research strategy identified a total of 11 articles related to older age and air travel, only three focused on passengers with cognitive impairment. Our literature review showed that the airplane environment may lead to a large spectrum of symptoms in passengers of all age groups. However, passengers with cognitive impairment due to neurodegenerative diseases are at increased risk for experiencing the most extreme symptoms such as acute confusional state. Non-pharmacological and pharmacological interventions at different stages of the travel process (before, during and after) can help prevent complications in this vulnerable population.

Conclusion
The decision to let a patient with cognitive impairment fly requires a solid understanding of the in-flight environmental changes and their impact on older patients with cognitive impairment. Moreover, a sound weighing of the risks and benefits while considering different aspects of the patient’s history is demanded. In this regard, the role of the treating physicians and caregivers is essential along with the support of the medical department of the airline.
Additive Uncorrelated Relaxed Clock Models for the Dating of Genomic Epidemiology Phylogenies
Authors: Didelot Xavier , Siveroni Igor , Volz Erik M 
Published: July 2020

AbstractPhylogenetic dating is one of the most powerful and commonly used methods of drawing epidemiological interpretations from pathogen genomic data. Building such trees requires considering a molecular clock model which represents the rate at which substitutions accumulate on genomes. When the molecular clock rate is constant throughout the tree then the clock is said to be strict, but this is often not an acceptable assumption. Alternatively, relaxed clock models consider variations in the clock rate, often based on a distribution of rates for each branch. However, we show here that the distributions of rates across branches in commonly used relaxed clock models are incompatible with the biological expectation that the sum of the numbers of substitutions on two neighboring branches should be distributed as the substitution number on a single branch of equivalent length. We call this expectation the additivity property. We further show how assumptions of commonly used relaxed clock models can lead to estimates of evolutionary rates and dates with low precision and biased confidence intervals. We therefore propose a new additive relaxed clock model where the additivity property is satisfied. We illustrate the use of our new additive relaxed clock model on a range of simulated and real data sets, and we show that using this new model leads to more accurate estimates of mean evolutionary rates and ancestral dates.
Syringomyelia Resolution Following Chiari Surgery: A Novel Scale for Communication and Research
Authors: Lara-Reyna Jacques , Chae John , Tosi Umberto , Souweidane Mark M , Uribe-Cardenas Rafael , Greenfield Jeffrey P 
Published: July 2020

Abstract

BACKGROUND
The pathophysiological connection between Chiari malformation and syringomyelia is accepted. Debate remains, however, how can we best define changes in syringomyelia following surgery.

OBJECTIVE
To introduce a grading system focusing on syrinx reduction based on routinely and reproducible radiological information, and provide a suggestion of the application of this scale for prediction of patient's prognoses.

METHODS
Data from 48 patients with Chiari malformation and syringomyelia were compiled. We calculated syrinx cross-sectional area by approximating an ellipse in the largest axial plane. We compared the percentage of reduction or enlargement following surgery. The percentage change was grouped into four grades: Grade 0 = Increasing size, grade I ≤ 50% reduction, grade II = 50% to 90% reduction, grade III ≥ 90% reduction.

RESULTS
A total of 89.6% of patients had syrinx improvement after surgery. A total of 5 patients were grade 0, 14 were grade I, 20 patients were grade II, and 9 patients met criteria for grade III. The mean postoperative syrinx area was 24.1 mm2 (0-169 mm2
) with a mean syrinx reduction of 62.7%.

CONCLUSION
Radiological improvement of syringomyelia can be mathematically defined and standardized to assist in communication in outcome-based trials. Radiological resolution is expected most patients.
Pediatric glioma and medulloblastoma risk and population demographics: a Poisson regression analysis
Authors: Muskens Ivo S , Feng Qianxi , Francis Stephen S , Walsh Kyle M , Mckean-Cowdin Roberta , Gauderman William J , de Smith Adam J , Wiemels Joseph L 
Published: July 2020

Abstract

Background
The incidence of pediatric brain tumors varies by race and ethnicity, but these relationships may be confounded by socioeconomic status (SES). In this study, the Surveillance, Epidemiology, and End Results Program (SEER) database was evaluated for associations between race/ethnicity and pediatric glioma and medulloblastoma risk with adjustment for SES.

Methods
Pediatric glioma and medulloblastoma cases from the SEER database (years: 2000–2016) were included. Differences in incidence rates by ethnicity, sex, age, and SES-related factors were evaluated by calculation of age-adjusted incidence rates (AAIRs) and annual percent change (APC). SES-related factors (percentage without less than high school graduation, median household income, and percentage foreign-born) were derived from the census at the county-level (year: 2000). Multivariable Poisson regression models with adjustment for selected covariates were constructed to evaluate risk factors.

Results
The highest AAIRs of pediatric glioma were observed among non-Hispanic Whites (AAIR: 2.91 per 100 000, 95%-CI: 2.84–2.99). An increasing incidence of pediatric glioma by calendar time was observed among non-Hispanic Whites and non-Hispanic Blacks (APC: 0.97%, 95%-CI: 0.28–1.68 and APC: 1.59%, 95%-CI: 0.03–3.18, respectively). Hispanic and non-Hispanic Black race/ethnicity was associated with lower risk when compared with non-Hispanic White (incidence rate ratios [IRRs]: 0.66, 95%-CI: 0.63–0.70; and 0.69, 95%-CI: 0.65–0.74, respectively). For medulloblastoma, the highest AAIR was observed for non-Hispanic Whites with a positive APC (1.52%, 95%-CI: 0.15–2.91). Hispanics and non-Hispanic Blacks had statistically significant lower IRRs compared with non-Hispanic Whites (IRRs: 0.83, 95%-CI: 0.73–0.94; and 0.72, 95%-CI: 0.59–0.87, respectively).

Conclusion
Non-Hispanic White race/ethnicity was associated with higher pediatric glioma and medulloblastoma IRRs in models with adjustments for SES.
Scambaiter Narratives of Victims and Offenders and Their Influence on the Policing of Fraud
Authors: Cross Cassandra , Mayers Duncan 
Published: July 2020

Abstract
Scambaiters have emerged as a proactive means to targeting fraud offenders. Put simply, scambaiters act as an incapacitator, seeking to deliberately engage fraud offenders to waste their time and reduce their communication with genuine victims. For some, this is a deliberate act of vigilantism that seeks to respond in a way that authorities (such as police) cannot. This article uses a well-known scambaiter website, 419eater, to examine how scambaiters present narratives of fraud victims and fraud offenders. It argues that victims are positioned as vulnerable and undeserving of their victimization, while offenders are positioned as rational beings and as a criminal ‘other’. This last narrative is used to justify the behaviour of scambaiters towards alleged fraud offenders. Overall, this article argues that while both narratives are based largely on facts, the interpretation and use of these narratives (particularly the offender narrative) are problematic in terms of a broader discussion around the policing of online fraud and cyber vigilantism.
The modulating impact of cigarette smoking on brain structure in panic disorder: a voxel-based morphometry study
Authors: Kunas Stefanie L , Hilbert Kevin , Yang Yunbo , Richter Jan , Hamm Alfons , Wittmann André , Ströhle Andreas , Pfleiderer Bettina , Herrmann Martin J , Lang Thomas , Lotze Martin , Deckert Jürgen , Arolt Volker , Wittchen Hans-Ulrich , Straube Benjamin , Kircher Tilo , Gerlach Alexander L , Lueken Ulrike 
Published: July 2020

Abstract
Cigarette smoking increases the likelihood of developing anxiety disorders, among them panic disorder (PD). While brain structures altered by smoking partly overlap with morphological changes identified in PD, the modulating impact of smoking as a potential confounder on structural alterations in PD has not yet been addressed. In total, 143 PD patients (71 smokers) and 178 healthy controls (62 smokers) participated in a multicenter magnetic resonance imaging (MRI) study. T1-weighted images were used to examine brain structural alterations using voxel-based morphometry in a priori defined regions of the defensive system network. PD was associated with gray matter volume reductions in the amygdala and hippocampus. This difference was driven by non-smokers and absent in smoking subjects. Bilateral amygdala volumes were reduced with increasing health burden (neither PD nor smoking &gt; either PD or smoking &gt; both PD and smoking). As smoking can narrow or diminish commonly observed structural abnormalities in PD, the effect of smoking should be considered in MRI studies focusing on patients with pathological forms of fear and anxiety. Future studies are needed to determine if smoking may increase the risk for subsequent psychopathology via brain functional or structural alterations.
Do gaze behaviours during action observation predict interpersonal motor resonance?
Authors: Bekkali Soukayna , Youssef George J , Donaldson Peter H , He Jason , Do Michael , Hyde Christian , Barhoun Pamela , Enticott Peter G 
Published: July 2020

Abstract
Interpersonal motor resonance (IMR) is a common putative index of the mirror neuron system (MNS), a network containing specialised cells that fire during both action execution and observation. Visual content inputs to the MNS, however, it is unclear whether visual behaviours mediate the putative MNS response. We aimed to examine gaze effects on IMR during action observation. Neurotypical adults (N = 99; 60 female) underwent transcranial magnetic stimulation, electromyography, and eye-tracking during the observation of videos of actors performing grasping actions. IMR was measured as a percentage change in motor evoked potentials (MEPs) of the first dorsal interosseous muscle during action observation relative to baseline. MEP facilitation was observed during action observation, indicating IMR (65.43%, SE = 11.26%, P &lt; 0.001). Fixations occurring in biologically relevant areas (face/hand/arm) yielded significantly stronger IMR (81.03%, SE = 14.15%) than non-biological areas (63.92%, SE = 14.60, P = 0.012). This effect, however, was only evident in the first of four experimental blocks. Our results suggest that gaze fixation can modulate IMR, but this may be affected by the salience and novelty of the observed action. These findings have important methodological implications for future studies in both clinical and healthy populations.
Cognitive processes during deception about attitudes revisited: a replication study
Authors: Scheuble V , Beauducel A 
Published: July 2020

Abstract
Event-related potential (ERP) studies about deception often apply recognition tasks. It remains questionable whether reported ERP patterns and cognitive processes can be generalized to other contexts. As the study by Johnson et al. (2008) fills this gap by investigating deception regarding attitudes, we tried to replicate it. Participants (N = 99) were instructed to lie or tell the truth about their attitudes. We obtained the same results as Johnson et al. (2008): lies were accompanied by enhanced medial frontal negativities (MFN) and suppressed late positive components (LPCs) indicating that lying relied on stronger cognitive control processes and response conflicts than being honest. The amplitudes of pre-response positivities (PRP) were reduced for lies implying that lies about attitudes were accompanied by strategic monitoring. MFN amplitudes increased and LPC amplitudes decreased for lies about positively valued items revealing that lying about positively valued items is cognitively more challenging than lying about negatively valued items. As a new finding, MFN, LPC and PRP components were neither moderated by Machiavellianism nor by changes in the attitude ratings. The results indicate that LPC, MFN and PRP components are reliable indicators of the cognitive processes used during deception and that it is worthwhile to investigate them in further deception contexts.