bluuebunny/crossref_metadata_2025_split huggingface dataset:
Large-domain stability of random attractors for stochastic g-Navier–Stokes equations with additive noise
Authors: Li Fuzhi , Xu Dongmei , She Lianbing 
Published: July 2020

AbstractThis paper concerns the long term behavior of the stochastic two-dimensional g-Navier–Stokes equations with additive noise defined on a sequence of expanding domains, where the ultimate domain is unbounded and of Poincaré type. We prove that the weak continuity is uniform with respect to all expanding cocycles, which yields the equi-asymptotic compactness by using an energy equation method. Finally, we show the existence of a random attractor for the equation on each domain and the upper semi-continuity of random attractors as the bounded domain is expanded to the unbounded ultimate domain.
A note on singular two-dimensional fractional coupled Burgers’ equation and triple Laplace Adomian decomposition method
Authors: Eltayeb Hassan , Bachar Imed 
Published: July 2020

AbstractThe present article focuses on how to find the exact solutions of the time-fractional regular and singular coupled Burgers’ equations by applying a new method that is called triple Laplace and Adomian decomposition method. Furthermore, the proposed method is a strong tool for solving many problems. The accuracy of the method is considered through the use of some examples, and the results obtained are compared with those of the existing methods in the literature.
Analysis of an improved fractional-order model of boundary formation in the Drosophila large intestine dependent on Delta-Notch pathway
Authors: Sun Deshun , Lu Lingyun , Liu Fei , Duan Li , Wang Daping , Xiong Jianyi 
Published: July 2020

AbstractIn this paper, an improved fractional-order model of boundary formation in the Drosophila large intestine dependent on Delta-Notch pathway is proposed for the first time. The uniqueness, nonnegativity, and boundedness of solutions are studied. In a two cells model, there are two equilibriums (no-expression of Delta and normal expression of Delta). Local asymptotic stability is proved for both cases. Stability analysis shows that the orders of the fractional-order differential equation model can significantly affect the equilibriums in the two cells model. Numerical simulations are presented to illustrate the conclusions. Next, the sensitivity of model parameters is calculated, and the calculation results show that different parameters have different sensitivities. The most and least sensitive parameters in the two cells model and the 60 cells model are verified by numerical simulations. What is more, we compare the fractional-order model with the integer-order model by simulations, and the results show that the orders can significantly affect the dynamic and the phenotypes.
2PC*: a distributed transaction concurrency control protocol of multi-microservice based on cloud computing platform
Authors: Fan Pan , Liu Jing , Yin Wei , Wang Hui , Chen Xiaohong , Sun Haiying 
Published: July 2020

AbstractThe two-phase commit (2PC) protocol is a key technique for achieving distributed transactions in storage systems such as relational databases and distributed databases. 2PC is a strongly consistent and centralized atomic commit protocol that ensures the serialization of the transaction execution order. However, it does not scale well to large and high-throughput systems, especially for applications with many transactional conflicts, such as microservices and cloud computing. Therefore, 2PC has a performance bottleneck for distributed transaction control across multiple microservices. In this paper, we propose 2PC*, a novel concurrency control protocol for distributed transactions that outperforms 2PC, allowing greater concurrency across multiple microservices. 2PC* can greatly reduce overhead because locks are held throughout the transaction process. Moreover, we improve the fault-tolerance mechanism of 2PC* using transaction compensation. We also implement a middleware solution for transactions in microservice support using 2PC*. We compare 2PC* to 2PC by applying both to Ctrip MSECP, and 2PC* outperforms 2PC in workloads with varying degrees of contention. When the contention becomes high, the experimental results show that 2PC* achieves at most a 3.3x improvement in throughput and a 67% reduction in latency, which proves that our scheme can easily support distributed transactions with multi-microservice modules. Finally, we embed our middleware scheme in the PaaS cloud platform and demonstrate its strong applicability to cloud computing through long-term analysis of the monitoring results in the cloud platform.
Simplified Effective Compressive Strengths of Columns with Intervening Floor Slabs
Authors: Choi Seung-Ho , Hwang Jin-Ha , Han Sun-Jin , Cho Hae-Chang , Kim Jae Hyun , Kim Kang Su 
Published: July 2020

AbstractThe current design codes discuss the effective compressive strengths of columns, which reflect a decrease in load transfer performance that can occur when columns and slabs have different concrete compressive strengths. The effective compressive strength of a column increases as it is confined by the slab, and the design codes mandate three different effective compressive strengths for interior columns (confinement on four sides), exterior columns (confinement on three sides), and corner columns (confinement on two sides). For both corner and exterior columns, the confinement effect of the slab is significantly smaller than that for the interior column, and there is a more marked decrease in load transfer performance. However, there is still a lack of theoretical studies investigating the effective compressive strengths of the corner and exterior columns. Therefore, based on the analysis model established in previous research, this study has proposed an equation for calculating the effective compressive strengths of the corner, exterior and isolated columns without any confinement effects of the slab. In addition, axial loading tests of isolated columns were conducted and the proposed equation was verified.
Impact of ENT resource nurses in improving operating room efficiency
Authors: Aravinthan Kaishan , Holmes Connor , Nair Sreejit P. , Sharma Anil R. , Murphy Russell A. 
Published: July 2020

Background Operating room (OR) efficiency is related to minutes spared from surgical time and has been linked to the make up of surgical teams and operating room workplace. The research on the efficiency of surgical nursing staff members is scant. The current study evaluates the effect of ENT trained OR resource nurses on the efficiency of operating time during ENT procedures. Methods Five hundred seventy-three ENT surgery cases from 4 surgeons were retrospectively reviewed. Two hundred forty-two cases had ENT OR nursing staff and 331 cases had non-ENT OR nursing staff. Requested operative times (ROT) and true operative times (TOT) were analyzed. The difference between the TOT and ROT was used to measure operating time efficiency. Results Cases with ROT < 30 min (M = -1.19, SD = 5.01) required 3.34 min less than planned for when an ENT nurse was present compared to those with non-ENT nursing staff which required on average 2.15 min (M = 2.15, SD = 5.68) longer than ROT. Furthermore, cases with ROT > 30 min (M = -4.32, SD = 10.85) required 10.85 min less than planned for when an ENT nurse was present. Conversely with non-ENT nursing staff cases with a ROT > 30 min required on average 6.53 min (M = 6.53, SD = 11.85) longer than ROT. Conclusion ENT resource nurses were shown to improve OR efficiency in cases less than 30 min and greater than 30 min. Cases that were greater than 30 min showed the largest increase in efficiency. Specialized ENT nursing staff improved efficiency during common ENT surgeries. Graphical Abstract
Multi-layered deep learning perceptron approach for health risk prediction
Authors: Bikku Thulasi 
Published: July 2020

AbstractIn today's world, due to the increase of medical data there is an interest in data preprocessing, classification and prediction of disease risks. Machine learning and Artificial Intelligence indicates that the predictive analysis becomes part of the medical activities especially in the domain of medical death prevention. The proposed work is focused on supervised learning methods and their capability to find hidden patterns in the real historical medical data. The objective is to predict future risk with a certain probability using Multi-layer perceptron (MLP) method. In the proposed work, MLP based on data classification technique is used for accurate classification and risk analysis of medical data. The proposed method is compared with traditional classification methods and the results show that the proposed method is better than the traditional methods.
Self-emulsifying formulation of Spinacia oleracea reduces the dose and escalates bioavailability of bioactive compounds to accelerate fracture repair in rats
Authors: Trivedi Ritu , Adhikary Sulekha , Kothari Priyanka , Ahmad Naseer , Mittapelly Naresh , Pandey Gitu , Shukla Mahendra , Kumar Sudhir , Dev Kapil , Choudhary Dharmendra , Maurya Rakesh , Lal Jawahar , Mishra Prabhat Ranjan 
Published: July 2020

Abstract
Background
Spinach (Spinacia oleracea) is a rich source of flavonoids and therefore widely used therapeutically as an antioxidant agent in traditional medicine. The present study was undertaken to study the bone regenerating property of dried Spinacia oleracea extract (DSE) and self-emulsifying formulation of the extract (FDSE) on drill-hole model of fracture repair in rats.

Methods
0.8 mm hole was drilled in the diaphyseal region of femur in adult SD rats. DSE and formulated extract (FDSE) was administered orally and fractured femur was collected after treatment regimen. Micro-CT, transcriptional analysis and measurement of calcein intensity of callus formed at the injured site was performed to study the efficacy of the extract and formulation on bone regeneration. Further, compounds from extract were assessed for in-vitro osteoblast activity.

Results
Micro-architecture of the regenerated bone at injured site exhibited 26% (p < 0.001) and 35% (p < 0.01) increased BV/TV (bone volume /tissue volume) and Tb.N. (trabecular number) for DSE (500 mg.kg− 1). Further, FDSE exhibited similar augmentation in BV/TV (p < 0.01) and Tb. N (p < 0.01) parameters at dose of 250 mg.kg− 1. Analogous results were obtained from transcriptional analysis and calcein intensity at the fractured site. 3-O-Methylpatuletin, one of the compound isolated from the extract stimulated the differentiation and mineralization of primary osteoblast and depicted concentration dependent antagonizing effect of H2O2 in osteoblast apparently, minimizing ROS generation thus affectivity in fracture repair.

Conclusions
The present study showed that bone regenerating property of spinach was augmented by formulating extract to deliverable form and can be further studied to develop as therapeutic agent for fracture repair.

Graphical abstract
Serum zinc and copper levels in a sample of Egyptian epileptic children
Authors: Eissa Mona A. , Abdulghani Khaled O. , Nada Maha A. , Elkhawas Hala M. , Shouman Ahmed E. , Ahmed Nahed S. 
Published: July 2020

Abstract
Background
Epilepsy is among the most common disabling neurological disorders among children. Altered serum levels of zinc and copper may facilitate seizure occurrence and repetition, and antiepileptic drugs may disturb their serum levels affecting disease control and outcome.

Objective
To investigate the association between serum levels of zinc and copper and epilepsy and antiepileptic treatment in a group of Egyptian epileptic children.

Methods
Case-control study on 100 epileptic patients, aged from 2 to 16 years, from neurology outpatient clinic and 50 apparently healthy children with matched age and sex. Venous samples were withdrawn from patients and controls then serum levels of zinc and copper were measured with graphite furnace atomic absorption spectrometer-A Analyst 800.

Results
Serum zinc level of patients’ group was significantly lower than that of controls with a mean of 59.1 μ/dL ± 22.7 and 85 μ/dL ± 22.2, respectively (P < 0.01). Serum zinc level of patients with history of febrile seizures was significantly decreased compared to patients without history of febrile seizures with a mean of 41.5 μ/dL ± 20.1 and 67.9 μ/dL ± 19.3, respectively (P < 0.01). Patient on carbamazepine intake showed significantly lower zinc serum level than patients without carbamazepine intake, with a mean of 49.0 μ/dL ± 17 and 61.8 μ/dL ± 23.4, respectively (P < 0.01). A significant negative correlation was noted between the duration of illness of epilepsy and the mean copper serum level (P < 0.05).

Conclusion
Zinc and copper altered homeostasis have mounting evidence about their role in the pathogenesis of epilepsy. Designing treatment plans that selectively restore zinc and copper normal levels may be a beneficial strategy in the future.
Molecular Interaction Between Butorphanol and κ-Opioid Receptor
Authors: Ji Jiafu , Lin Wenzhen , Vrudhula Amey , Xi Jin , Yeliseev Alexei , Grothusen John R. , Bu Weiming , Liu Renyu 
Published: July 2020

BACKGROUND:
The misuse of opioids stems, in part, from inadequate knowledge of molecular interactions between opioids and opioid receptors. It is still unclear why some opioids are far more addictive than others. The κ-opioid receptor (KOR) plays a critical role in modulating pain, addiction, and many other physiological and pathological processes. Butorphanol, an opioid analgesic, is a less addictive opioid with unique pharmacological profiles. In this study, we investigated the interaction between butorphanol and KOR to obtain insights into the safe usage of this medication.

METHODS:
We determined the binding affinity of butorphanol to KOR with a naltrexone competition study. Recombinant KORs expressed in mammalian cell membranes (Chem-1) were used for G-protein activation studies, and a human embryonic kidney-293 (HEK-293) cell line stably transfected with the human KOR was used for β-arrestin study as previously described in the literature. The effects of butorphanol on KOR internalization were investigated using mouse neuroblastoma Neuro2A cells stably transfected with mKOR–tdTomato fusion protein (N2A-mKOR-tdT) cells overexpressing KOR. The active-state KOR crystal structure was used for docking calculation of butorphanol to characterize the ligand binding site. Salvinorin A, a full KOR agonist, was used as a control for comparison.

RESULTS:
The affinity of KOR for butorphanol is characterized by Kd of 0.1 ± 0.02 nM, about 20-fold higher compared with that of the µ-opioid receptor (MOR; 2.4 ± 1.2 nM). Our data indicate that butorphanol is more potent on KOR than on MOR. In addition, butorphanol acts as a partial agonist of KOR in the G-protein activation pathway and is a full agonist on the β-arrestin recruitment pathway, similar to that of salvinorin A. The activation of the β-arrestin pathway is further confirmed by KOR internalization. The in silico docking model indicates that both salvinorin A and butorphanol share the same binding cavity with the KOR full agonist MP1104. This cavity plays an important role in determining either agonist or antagonist effects of the ligand.

CONCLUSIONS:
In conclusion, butorphanol is a partial KOR agonist in the G-protein activation pathway and a potent KOR full agonist in the β-arrestin recruitment pathway. The structure analysis offers insights into the molecular mechanism of KOR interaction and activation by butorphanol.
Reflection Versus Rebreathing for Administration of Sevoflurane During Minor Gynecological Surgery
Authors: Kermad Azzeddine , Appenzeller Madeleine , Morinello Emanuela , Schneider Sven Oliver , Kleinschmidt Stefan , O‘Gara Brian , Volk Thomas , Meiser Andreas 
Published: July 2020

BACKGROUND:
Contemporary anesthetic circle systems, when used at low fresh gas flows (FGF) to allow rebreathing of anesthetic, lack the ability for rapid dose titration. The small-scale anesthetic reflection device Anaesthetic Conserving Device (50mL Version; AnaConDa-S) permits administration of volatile anesthetics with high-flow ventilators. We compared washin, washout, and sevoflurane consumption using AnaConDa-S versus a circle system with low and minimal FGF.

METHODS:
Forty patients undergoing breast surgery were randomized to receive 0.5 minimal alveolar concentration (MAC) sevoflurane with AnaConDa-S (21 patients, reflection group) or with a circle system (low flow: FGF = 0.2 minute ventilation [V′E], 9 patients; or minimal flow: 0.1 V′E, 10 patients). In the reflection group, syringe pump boluses were given for priming and washin; to simulate an open system, the FGF of the anesthesia ventilator was set to 18 L·min−
1 with the soda lime removed. In the other groups, the FGF was increased for washin (1 V′E for 8 minutes) and washout (3 V′E). For all patients, tidal volume was 7 mL·kg−
1 and the respiratory rate adjusted to ensure normoventilation. Analgesia was attained with remifentanil 0.3 µg·kg−1·min−1. Sevoflurane consumption was compared between the reflection group and the low- and minimal-flow groups, respectively, using a post hoc test (Fisher Least Significant Difference). To compare washin and washout (half-life), the low- and minimal-flow groups were combined.

RESULTS:
Sevoflurane consumption was reduced in the reflection group (9.4 ± 2.0 vs 15.0 ± 3.5 [low flow, P < .001] vs 11.6 ± 2.3 mL·MAC h−1 [minimal flow, P = .02]); washin (33 ± 15 vs 49 ± 12 seconds, P = .001) and washout (28 ± 15 vs 55 ± 19 seconds, P < .001) times were also significantly shorter.

CONCLUSIONS:
In this clinical setting with short procedures, low anesthetic requirements, and low tidal volumes, AnaConDa-S decreased anesthetic consumption, washin, and washout times compared to a circle system.
Altmetrics and citations: the impact of journal publications
Authors: Noah AO , Pearce I , Modgil V 
Published: July 2020

To assess the correlation between the altmetric attention score and citations as measures of impact for scholarly publications within and outside of the urological field, we compared altmetric attention scores and citations in two groups of journal articles, a urological group ( n=13) and a non-urological group ( n=129). All papers were high altmetric score publications. How researchers can benefit from alternative measures to make their mark.
Material suplementario Nota corta 78781. Depredación de Spea multiplicata (Anura: Scaphiopodidae) por Diadophis punctatus (Squamata: Dipsadidae) en un campo de cultivo en el occidente de México
Authors: Dávalos-M Aldo , Najar-S Jorge Antonio , Cruz-S Daniel 
Published: July 2020

Material suplementario Nota corta 78781. Tablas 1 – 2 y Fig. 1.
A Randomized, Double-Blind, Placebo-Controlled, Phase II Study of Regorafenib Versus Placebo in Advanced/Metastatic, Treatment-Refractory Liposarcoma: Results from the SARC024 Study
Authors: Riedel Richard F. , Ballman Karla V. , Lu Yao , Attia Steven , Loggers Elizabeth T. , Ganjoo Kristen N. , Livingston Michael B. , Chow Warren , Wright Jennifer , Ward John H. , Rushing Daniel , Okuno Scott H. , Reed Damon R. , Liebner David A. , Keedy Vicki L. , Mascarenhas Leo , Davis Lara E. , Ryan Christopher , Reinke Denise K. , Maki Robert G. 
Published: July 2020

Abstract

Trial Information
Click here to access other published clinical trials.

Lessons Learned
The results from the liposarcoma cohort of SARC024 confirm previously published data and do not support the routine use of regorafenib in this patient population. Continued exploration of novel therapies, including combination approaches, is warranted for a patient population in whom limited treatment options exist.

Background
Regorafenib is a multitargeted kinase inhibitor with a kinase profile overlapping, but distinct from, pazopanib, an agent approved for recurrent and metastatic non-gastrointestinal stromal tumor (GIST), non-adipocytic soft tissue sarcoma. We conducted a randomized, phase II study of regorafenib versus placebo in refractory liposarcoma patients.

Methods
Patients with advanced or metastatic, treatment-refractory liposarcoma were randomized 1:1 to receive regorafenib 160 mg or placebo once daily (3 weeks on, 1 week off). Patients with well-differentiated liposarcoma only were excluded. Crossover for placebo was allowed upon progression. The primary endpoint was progression-free survival (PFS), according to RECIST version 1.1.

Results
Forty-eight subjects with liposarcoma (34 dedifferentiated, 12 myxoid/round cell, 2 pleomorphic) were enrolled. Median PFS was 1.87 (95% confidence interval [CI], 0.92–3.67) months for regorafenib versus 2.07 (95% CI, 1.64–3.44) months for placebo; stratified hazard ratio [HR], 0.85 (95% CI, 0.46, 1.58), p = .62. No responses were seen on regorafenib. One PR was observed on placebo. Median overall survival was 6.46 (95% CI, 4.16–23.48) months for regorafenib and 4.89 (95% CI, 3.02–9.77) months for placebo, stratified HR, 0.66 (95% CI, 0.31–1.40), p = .28). Treatment-related adverse events were similar to the known safety profile of regorafenib.

Conclusion
Regorafenib did not appear to improve PFS in treatment-refractory liposarcoma. No new significant safety signals were observed.
Distortion of Nepalese Culture and Social Norms in Upadhyay’s Buddha’s Orphans
Authors: Adhikary Ramesh Prasad 
Published: July 2020

This research article is mainly focused on how Samrat Upadhyay has distorted Nepalese Culture and social norms in is novel Buddha’s Orphans. Nepalese culture and society are represented in a biased way from the western perspective. By using oriental stereotypes, the author has represented Nepal and the religious belief of Nepalese people in the wrong way. The characters of this novel like Bokey Ba, Kaki, Raja, Jamuna, and Ganga Da are presented as irrational and badly conservative people who believe in witch doctors, not in the medical doctors. They are presented as impulsive and eccentric. The setting of this novel is represented as exotic, inscrutable, and mysterious. Kathmandu valley and Nepalese people didn’t well describe as the real Kathmandu. As a qualitative research, the researcher has taken the novel as a primary text and the concepts from orientalism, and the Foucauldian notion of representation is used as a tool to interpret the text. The researcher concluded that the novel is the misrepresentation of Nepalese culture and society.
Indications and outcomes of tracheostomy in intensive care unit
Authors: Rahman Mukhlesur , Begum Mahmuda , Khan Mujibul Hoque , Anwar Mostsfa Mahfuzul 
Published: July 2020

<p><strong> </strong></p><p class="abstract"><strong>Background:</strong> Tracheostomy is a commonly performed surgical procedure in the intensive care unit (ICU) in which creation of a stoma between the skin and the anterior wall of the trachea where there is need for prolong mechanical ventilation. Tracheostomy has considered a safe procedure in ICU but has been found to lead to life threatening complications intra and post operatively.</p><p class="abstract"><strong>Methods:</strong> This is a cross sectional study, was carried out in ICU, Chittagong Medical College Hospital, Chattogram from January 2018 to December 2019. A total of 120 patients irrespective of age and sex whose tracheostomy has done after admission in ICU by ENT surgeons. </p><p class="abstract"><strong>Results:</strong> Out of 120 patients maximum 34 (28.33%) were from 21-30 years age group and male to female ratio was 1.79:1, male patients were 77 (64.16%) and female patients were 43 (35.83%). The most common indication for tracheostomy in ICU was head injury and history of RTA 34 (28.33%) followed by post-operative case of intracranial space occupying lesion 30 (25%). Post tracheostomy complication was surgical emphysema 4 (3.33%). The rate of complication of tracheostomy in ICU was 10.83% in this study. Regarding benefits of tracheostomy over endotracheal tube in ICU, we found that 100% patients had greater comfort.</p><p class="abstract"><strong>Conclusions:</strong> Tracheostomy in ICU is an important and safe procedure if prolonged endotracheal in tubation is advised for varying underlying causes.</p>