bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic findings in miscarriages and their relation to the number of previous miscarriages
Authors: Gomez R. , Hafezi N. , Amrani M. , Schweiger S. , Dewenter M. K. , Thomas P. , Lieb C. , Hasenburg A. , Skala C. 
Published: November 2020

Abstract
Purpose
Early pregnancy loss leads to a devastating situation for many couples. Genetic disorders found in the pregnancy tissue are a frequent cause of miscarriages. It is unclear whether maternal age or previous miscarriages are associated with a higher chromosomal anomaly rate. This study aimed to determine the cytogenetical distribution of chromosomal disorders in couples after one or more previous miscarriages as well as the influence of maternal age.

Methods
406 fetal tissue samples obtained after spontaneous abortion between 2010 and 2014 were successfully karyotyped. This included 132 couples with at least two losses and 274 couples with sporadic miscarriage. Normal and abnormal karyotype rate was determined for age, parity, gravidity, gestational week and number of previous miscarriages by logistic regression analysis.

Results
145 (35.71%) fetal tissue samples had a normal karyotype, and 261 (64.8%) did not.
After adjusting for age, older patients have a statistically significantly higher probability of genetic disorders in the pregnancy tissue (p < 0.001, OR 1.064, 95% CI 1.03–1.11). With each additional year, the probability of finding chromosomal abnormalities in a miscarriage increased by 6.4%. Patients younger than 35 years have a lower probability of having chromosomal disorders in the aborted material after two or more miscarriages than after sporadic miscarriages (50.7 vs. 58.9%) (p = 0.014, OR 0.67, 95% CI 0.48–0.914). Nevertheless, the risk of embryonic chromosomal disorders in patients aged 35 and above increased from 75.5% in sporadic miscarriages to 82.4% after more than one pregnancy losses (p = 0.59, OR 1.14, 95% CI  − 0.72 to 1.92).

Conclusion
Chromosomal disorders found after one or more previous miscarriages are related to patients’ age. Couples suffering two or more miscarriages should be further researched, especially in younger patients.
A unifying basis for the interplay of stress and chemical processes in the Earth: support from diverse experiments
Authors: Wheeler John 
Published: November 2020

AbstractThe interplay between stress and chemical processes is a fundamental aspect of how rocks evolve, relevant for understanding fracturing due to metamorphic volume change, deformation by pressure solution and diffusion creep, and the effects of stress on mineral reactions in crust and mantle. There is no agreed microscale theory for how stress and chemistry interact, so here I review support from eight different types of the experiment for a relationship between stress and chemistry which is specific to individual interfaces: (chemical potential) = (Helmholtz free energy) + (normal stress at interface) × (molar volume). The experiments encompass temperatures from -100 to 1300 degrees C and pressures from 1 bar to 1.8 GPa. The equation applies to boundaries with fluid and to incoherent solid–solid boundaries. It is broadly in accord with experiments that describe the behaviours of free and stressed crystal faces next to solutions, that document flow laws for pressure solution and diffusion creep, that address polymorphic transformations under stress, and that investigate volume changes in solid-state reactions. The accord is not in all cases quantitative, but the equation is still used to assist the explanation. An implication is that the chemical potential varies depending on the interface, so there is no unique driving force for reaction in stressed systems. Instead, the overall evolution will be determined by combinations of reaction pathways and kinetic factors. The equation described here should be a foundation for grain-scale models, which are a prerequisite for predicting larger scale Earth behaviour when stress and chemical processes interact. It is relevant for all depths in the Earth from the uppermost crust (pressure solution in basin compaction, creep on faults), reactive fluid flow systems (serpentinisation), the deeper crust (orogenic metamorphism), the upper mantle (diffusion creep), the transition zone (phase changes in stressed subducting slabs) to the lower mantle and core mantle boundary (diffusion creep).
Cognitive impairments are independently associated with shorter survival in diffuse glioma patients
Authors: van Kessel Emma , Huenges Wajer Irene M. C. , Ruis Carla , Seute Tatjana , Fonville Susanne , De Vos Filip Y. F. L. , Verhoeff Joost J. C. , Robe Pierre A. , van Zandvoort Martine J. E. , Snijders Tom J. 
Published: November 2020

Abstract
Background
Diffuse gliomas (WHO grade II–IV) are progressive primary brain tumors with great variability in prognosis. Cognitive deficits are of important prognostic value for survival in diffuse gliomas. Until now, few studies focused on domain-specific neuropsychological assessment and rather used MMSE as a measure for cognitive functioning. Additionally, these studies did not take WHO 2016 diagnosis into account. We performed a retrospective cohort study with the aim to investigate the independent relationship between cognitive functioning and survival in treatment-naive patients undergoing awake surgery for a diffuse glioma.

Methods
In patients undergoing awake craniotomy between 2010 and 2017, we performed pre-operative neuropsychological assessments in five cognitive domains, with special attention for the domains executive functioning and memory. We evaluated the independent relation between these domains and survival, in a Cox proportional hazards model that included state-of-the-art integrated histomolecular (‘layered’ or WHO-2016) classification of the gliomas and other known prognostic factors.

Results
We included 197 patients. Cognitive impairments (Z-values ≦ − 2.0) were most frequent in the domains memory (18.3%) and executive functioning (25.9%). Impairments in executive functioning and memory were significantly correlated with survival, even after correcting for the possible confounders. Analyses with the domains language, psychomotor speed, and visuospatial functioning yielded no significant results. Extensive domain-specific neuropsychological assessment was more strongly correlated to survival than MMSE.

Conclusion
Cognitive functioning is independently related to survival in diffuse glioma patients. Possible mechanisms underlying this relationship include the notion of cognitive functioning as a marker for diffuse infiltration of the tumor and the option that cognitive functioning and survival are determined by overlapping genetic pathways and biomarkers.
Effects of Tongue-Strengthening Self-Exercises in Healthy Older Adults: A Non-Randomized Controlled Trial
Authors: Yano Jitsuro , Nagami Shinsuke , Yokoyama Tomonori , Nakamura Katsuya , Kobayashi Miyu , Odan Yuki , Hikasa Miyako , Hanayama Kozo , Fukunaga Shinya 
Published: November 2020

AbstractTongue-strengthening exercises (TSE) using a device have been proposed as an intervention for improving tongue strength and endurance. However, devices for TSE have been expensive and difficult to manipulate and are not commonly used in home or clinical settings. This study therefore aimed to investigate whether tongue-strengthening self-exercises (TSsE) using a tongue-strengthening self-exercise tool at home can improve tongue strength in healthy older adults. This study included 27 participants (exercise group, η = 16, 7 men, 9 women, median age 84.5 years; control group, n = 11, 2 men, 9 women, median age 79.0 years). Exercises in the exercise group consisted of pushing the anterior tongue against the hard palate 30 times, 3 times a day, 5 days a week, for 8 weeks using a tongue-strengthening self-exercise tool. This tool is available in five levels of hardness. The most suitable hardness of the tool for each participant was calculated based on 60% of maximum tongue pressure (MTP) during the first 2 weeks of the training period and 80% of MTP for the remainder of the training period, as assessed using a tongue pressure-measuring device. The exercise group showed a significant improvement of 4.1 kPa in MTP (an 11.53% increase) and 4.53 s in endurance of tongue pressure (ETP) (a 99.86% increase). Furthermore, adherence in the exercise group was 99.2%. In conclusion, performing TSsE for 8 weeks was effective for increasing MTP and ETP in healthy older adults. This indicates that TSsE may be useful in older individuals at home to prevent age-related tongue muscle weakness.
Seasonal variation of blood pressure in children
Authors: Ziegelasch Niels , Vogel Mandy , Siekmeyer Werner , Billing Heiko , Dähnert Ingo , Kiess Wieland 
Published: November 2020

AbstractSeasonal blood pressure (BP) variation is mostly found between the summer and winter months. Guidelines for diagnosis and treatment of hypertension in children have not considered this variation until recently. This review aims to present an overview of seasonal BP variation in childhood along with potential underlying pathophysiological mechanisms and long-term implications as well as conclusions for future studies. In pediatric cohorts, seven studies investigated seasonal changes in BP. These changes amount to 3.4–5.9 mmHg (or 0.5–1.5 mmHg per − 1 °C difference in environmental temperature) in systolic BP with a peak in fall or winter. Potential mechanisms and mediators of seasonal BP variation include sympathetic activation of the nervous system with an increase of urinary and plasma norepinephrine levels in the winter season. Additionally, the physical activity among children and adolescents was inversely correlated with BP levels. Temperature sensitivity of BP and pediatric BP levels predict future systolic BP and target-organ damage. Therefore, cardiovascular events may even be long-term complications of seasonal BP variation in pediatric hypertensive patients. Overall, these data strongly suggest an important effect of ambient temperature on BP in children. Additional studies in pediatric cohorts are needed to define how best to incorporate such variation into clinical practice.
BIM-basierte digitale Transformation im Untertagebau anhand von zwei anwendungsorientierten Forschungsprojekten
Authors: Mazak-Huemer Alexandra , Galler Robert , Wenighofer Robert , Vierhauser Michael , Huemer Christian 
Published: November 2020

ZusammenfassungEs gibt zahlreiche Publikationen, die die digitale Transformation im Tief- und Tunnelbau propagieren. Als Lösungsansatz wird dabei immer wieder Building Information Modeling (BIM) genannt und die Umsetzung der digitalen Transformation basierend auf dieser Methodik gefordert. Der prototypische Charakter eines Tunnelbauprojekts erschwert jedoch eine standardisierte Vorgehensweise. Hinzu kommt, dass die beteiligten Fachdisziplinen für unterschiedliche Gewerke individuelle Softwaretools mit proprietären (nicht standardisierten) Datenformaten nutzen. Durch diese in sich geschlossenen Datenmodelle ist eine offene BIM Arbeitsweise (Open BIM) nur schwer zu realisieren. Das hat der Lehrstuhl für Subsurface Engineering an der Montanuniversität Leoben zum Anlass genommen und zwei anwendungsorientierte Forschungsprojekte zur digitalen Transformation im Tief- und Tunnelbau lanciert, deren Inhalte in diesem Artikel kurz vorgestellt werden. Das „Zentrum am Berg (ZaB)“ dient in beiden Projekten als zentrale Infrastruktur zu Evaluierungszwecken.
Returning to work in lung cancer survivors—a multi-center cross-sectional study in Germany
Authors: Rashid Humayra , Eichler Martin , Hechtner Marlene , Gianicolo Emilio , Wehler Beatrice , Buhl Roland , Schmidberger Heinz , Stratmann Jan A. , Gohrbandt Bernhard , Kortsik Cornelius , Nestle Ursula , Wirtz Hubert , Blettner Maria , Singer Susanne 
Published: November 2020

AbstractPurposeTo investigate the work situation of lung cancer survivors and to identify the factors associated with their returning to work.MethodsDescriptive analysis and logistic regression were used to evaluate study population characteristics and independent factors of subsequently returning to work. To analyze time to return to work, Cox regression was used.ResultsThe study sample included 232 lung cancer survivors of working age from 717 enrolled participants in the multi-center cross-sectional LARIS (Quality of Life and Psychosocial Rehabilitation in Lung Cancer Survivors) study. About 67% of the survivors were not employed during the survey. More than 51% of the survivors who were employed before their illness did not return to their work. The survivors who had returned to their careers were younger, associated with higher household income, lower fatigue score, and stable relationship and vocational training. Patients who received social service counseling showed a higher chance of regaining their career.ConclusionsLung cancer survivors were found to be associated with a high risk of unemployment and very low professional reintegration after interruption due to illness. More comprehensive studies are needed to support lung cancer survivors and targeting of patients in need of special attention in rehabilitation that would benefit from the findings in the present study.
Proteomic comparison of different synaptosome preparation procedures
Authors: Gulyássy Péter , Puska Gina , Györffy Balázs A. , Todorov-Völgyi Katalin , Juhász Gábor , Drahos László , Kékesi Katalin Adrienna 
Published: November 2020

AbstractSynaptosomes are frequently used research objects in neurobiology studies focusing on synaptic transmission as they mimic several aspects of the physiological synaptic functions. They contain the whole apparatus for neurotransmission, the presynaptic nerve ending with synaptic vesicles, synaptic mitochondria and often a segment of the postsynaptic membrane along with the postsynaptic density is attached to its outer surface. As being artificial functional organelles, synaptosomes are viable for several hours, retain their activity, membrane potential, and capable to store, release, and reuptake neurotransmitters. Synaptosomes are ideal subjects for proteomic analysis. The recently available separation and protein detection techniques can cope with the reduced complexity of the organelle and enable the simultaneous qualitative and quantitative analysis of thousands of proteins shaping the structural and functional characteristics of the synapse. Synaptosomes are formed during the homogenization of nervous tissue in the isoosmotic milieu and can be isolated from the homogenate by various approaches. Each enrichment method has its own benefits and drawbacks and there is not a single method that is optimal for all research purposes. For a proper proteomic experiment, it is desirable to preserve the native synaptic structure during the isolation procedure and keep the degree of contamination from other organelles or cell types as low as possible. In this article, we examined five synaptosome isolation methods from a proteomic point of view by the means of electron microscopy, Western blot, and liquid chromatography-mass spectrometry to compare their efficiency in the isolation of synaptosomes and depletion of contaminating subcellular structures. In our study, the different isolation procedures led to a largely overlapping pool of proteins with a fairly similar distribution of presynaptic, active zone, synaptic vesicle, and postsynaptic proteins; however, discrete differences were noticeable in individual postsynaptic proteins and in the number of identified transmembrane proteins. Much pronounced variance was observed in the degree of contamination with mitochondrial and glial structures. Therefore, we suggest that in selecting the appropriate isolation method for any neuroproteomics experiment carried out on synaptosomes, the degree and sort/source of contamination should be considered as a primary aspect.
Cerebral cavernous malformation remnants after surgery: a single-center series with long-term bleeding risk analysis
Authors: Fontanella Marco M. , Agosti Edoardo , Zanin Luca , di Bergamo Lodovico Terzi , Doglietto Francesco 
Published: November 2020

AbstractThe aim of this work is to investigate the long-term bleeding risk of cerebral cavernous malformation (CCM) remnants. A review of clinical, radiological, operative, and post-operative data of a cerebral cavernous malformation (CCMs) prospective database was performed. Fisher’s exact test and Mann-Whitney U-test were used to assess differences between non-hemorrhagic and hemorrhagic CCM remnants for 14 variables. Recursive partitioning analysis was performed to assess the order of variables most associated with CCM remnant bleeding. Twenty-four patients out of 126 had a CCM post-surgical remnant. Of these, 7 had at least one post-operative hemorrhagic event. The mean follow-up was 80.7 months (range 12–144). CCM post-surgical remnant bleeding presented mostly with acute headache (50%) and focal neurological deficit (25%); in the remaining cases, the hemorrhage was asymptomatic. Retreatment was performed in two patients, with surgery and radiosurgery, respectively; no treatment was performed in the majority of cases. All patients ranked as non-II, according to Zabramski classification, did not show any post-surgical bleeding. The presence of a pre-operative perilesional hemosiderin ring was highly significant in predicting post-surgical bleeding (sensitivity = 0.94, specificity = 0.88) and incorrectly predicted bleeding in only two of the 24 patients. This study provides an evaluation of clinical and radiological factors influencing the bleeding risk of a CCM post-surgical remnant in a homogeneous population. Perilesional hemosiderin ring and Zabramski Type II appear to strongly condition the bleeding risk of a CCM post-surgical remnant.
Standardized fluoroscopy-guided implantation technique enables optimal electrode placement in sacral neuromodulation: a cadaver study
Authors: Müller C. , Reissig L. F. , Argeny S. , Weninger W. J. , Riss S. 
Published: November 2020

Abstract
Background
Sacral neuromodulation (SNM) is an established treatment option for patients with faecal incontinence. The location of the stimulating electrode is considered to be essential for treatment success. The purpose of this study was to evaluate the position of SNM electrodes after using a standardized fluoroscopy-guided implantation technique.

Methods
For this cadaver study, SNM electrodes were implanted bilaterally in 5 lower body specimens. The lower edge of the sacroiliac joint and the medial edge of the sacral foramina were marked using fluoroscopy to draw an ‘H’ with the crossing points identifying S3. After electrode placement the pelvis was dissected to describe the exact position of the SNM electrodes.

Results
The electrodes were inserted at an angle with a median degree measure of 60° (range 50–65°) to the skin, with a median distance of 9 mm (range 0–13 mm) from the S3 marking. All electrodes entered the third sacral foramen. The median distance of the electrodes to the sacral nerve was 0 mm (range 0–3 mm) for the most proximal, 0.5 mm (range 0–5 mm) for the second, 2.25 mm (range 0–11 mm) for the third and 1.75 mm (range 0–16 mm) for the most distant electrode. There was neither a significant difference in the proximity of the electrodes to the nerve between the right and left side (proximal to distal electrode: p = 0.18, p = 0.16, p = 0.07, p = 0.07) nor between male and female cadavers (p = 0.25, p = 0.21, p = 0.66, p = 0.66).

Conclusions
A standardized fluoroscopy-guided implantation technique enables a close contact between electrode and nerve. This can potentially result in an improved clinical outcome.
Quotas: Enabling Conscientious Objection to Coexist with Abortion Access
Authors: Rodger Daniel , Blackshaw Bruce P. 
Published: November 2020

AbstractThe debate regarding the role of conscientious objection in healthcare has been protracted, with increasing demands for curbs on conscientious objection. There is a growing body of evidence that indicates that in some cases, high rates of conscientious objection can affect access to legal medical services such as abortion—a major concern of critics of conscientious objection. Moreover, few solutions have been put forward that aim to satisfy both this concern and that of defenders of conscientious objection—being expected to participate in the provision of services that compromise their moral integrity. Here we attempt to bring some resolution to the debate by proposing a pragmatic, long-term solution offering what we believe to be an acceptable compromise—a quota system for medical trainees in specialties where a conscientious objection can be exercised, and is known to cause conflict. We envisage two main objectives of the quota system we propose. First, as a means to introduce conscientious objection into countries where this is not presently permitted. Second, to minimise or eliminate the effects of high rates of conscientious objection in countries such as Italy, where access to legal abortion provision can be negatively affected.
Toward accurate density and interfacial tension modeling for carbon dioxide/water mixtures
Authors: Cui Zixuan , Li Huazhou 
Published: November 2020

AbstractPhase behavior of carbon dioxide/water binary mixtures plays an important role in various CO2-based industry processes. This work aims to screen a thermodynamic model out of a number of promising candidate models to capture the vapor–liquid equilibria, liquid–liquid equilibria, and phase densities of CO2/H2O mixtures. A comprehensive analysis reveals that Peng–Robinson equation of state (PR EOS) (Peng and Robinson 1976), Twu α function (Twu et al. 1991), Huron–Vidal mixing rule (Huron and Vidal 1979), and Abudour et al. (2013) volume translation model (Abudour et al. 2013) is the best model among the ones examined; it yields average absolute percentage errors of 5.49% and 2.90% in reproducing the experimental phase composition data and density data collected in the literature. After achieving the reliable modeling of phase compositions and densities, a new IFT correlation based on the aforementioned PR EOS model is proposed through a nonlinear regression of the measured IFT data collected from the literature over 278.15–477.59 K and 1.00–1200.96 bar. Although the newly proposed IFT correlation only slightly improves the prediction accuracy yielded by the refitted Chen and Yang (2019)’s correlation (Chen and Yang 2019), the proposed correlation avoids the inconsistent predictions present in Chen and Yang (2019)’s correlation and yields smooth IFT predictions.
An Effort Towards Full Graphene Photodetectors
Authors: Larki Farhad , Abdi Yaser , Kameli Parviz , Salamati Hadi 
Published: November 2020

AbstractGraphene as a truly 2-dimensional (2D) system is a promising candidate material for various optoelectronic applications. Implementing graphene as the main building material in ultra-broadband photodetectors has been the center of extensive research due to its unique absorption spectrum which covers most of the electro-magnetic spectra. However, one of the main challenges facing the wide application of pure graphene photodetectors has been the small optical absorption of monolayer graphene. Although novel designs were proposed to overcome this drawback, they often need complicated fabrication processes in order to integrate with the graphene photodetector. In this regard, fabrication of purely graphene photodetectors is a promising approach towards the manufacturing of simple, inexpensive, and high photosensitive devices. The fabrication of full graphene photodetectors (FGPDs) is mainly based on obtaining an optimal technique for the growth of high quality graphene, modification of electronic and optical properties of the graphene, appropriate techniques for transfer of graphene from the grown substrate to the desire position, and a proper design for photodetection. Therefore, the available states of the art techniques for each step of device fabrication, along with their pros and cons, are reviewed and the possible approaches for optimization of FGPDs have been proposed.