bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlations in parameters of balance between fathers and their adult sons
Authors: Naczk Mariusz , Bezulska Anna , Adach Zdzisław , Celichowski Jan 
Published: October 2019

Abstract
Background : The literature data suggest that balance control is genetically determined, however the data are inconsistent with respect to correlations in balance parameters among adult relatives. Therefore, the aim of the present study was to identify correlations between fathers and their adult sons in chosen balance parameters. Moreover, we tested how the relationships in balance between fathers and their adult sons change following fatigue. Methods: The balance parameters were measured twice: before and immediately after the fatigue procedure (treadmill running to exhaustion) with the pedographic platform in two groups of relatives and correlated for 30 pairs father-adult son.Results: The positive significant correlations were found for parameters describing deflection in the sagittal plane: the average deflection of center of pressure progression (COPP) and average value of COPP velocity in sagittal plane as well as the average value of velocity of COPP, the length of COPP trajectory and the surface area of the trajectory covered by COPP, both before and after the fatigue procedure. Conclusions: In summary, our study found numerous correlations in balance parameters related to deflection in the sagittal plane between fathers and their adult sons. These correlations were not abolished by fatigue. Our results suggest that the ability to maintain balance is influenced by genetics. This conclusion can be useful in many sports in which the ability to maintain balance influence on sports score.
Emergence delirium and intranasal dexmedetomidine premedication in pediatric anesthesia: a retrospective study in plastic surgery
Authors: Palma Alessandra Di , Maldarelli Federica , Cimino Antonietta , Zama Mario , Picardo Sergio Giuseppe 
Published: October 2019

Abstract
Background Dexmedetomidine is widely used in the treatment of emergency delirium (ED) in pediatric patients. However, further evidence on its use in pediatric anesthesia on potential differences in the reduction of ED according to patient’s age and type of anesthesia is required. Moreover, whether dexmedetomidine influences time of discharge from the surgical area remains unclear. We evaluated whether intranasal dexmedetomidine is effective in decreasing the incidence of ED in 106 children who had anesthesia for plastic surgery undergoing general or combined anesthesia at different ages. We also assessed if this drug has an impact on time to discharge from the surgical area. Methods In total, 106 children, aged 2–10 years, were enrolled in this retrospective study. Among them, 50 have been premedicated with dexmedetomidine (dexmedetomidine group); the remaining 56 patients served as controls (control group). The incidence of ED was evaluated according to the use of dexmedetomidine premedication, age and type of anesthesia (general vs combined). The length of anesthesia and duration of staying in the surgical area were also analyzed. Results Three patients who received dexmedetomidine premedication showed ED (6%), compared with 43 patients in the control group (77%; p<0.05). This lower incidence of ED was also present when stratifying patients according to the type of anesthesia or age. No difference between the dexmedetomidine group and control group were reported in timing of discharge from surgical area.Conclusions Premedication with dexmedetomidine is associated with decreased incidence of ED without increasing timing of discharge after surgery, regardless of patients’ age or type of anesthesia. In particular, patients subjected to combined anesthesia report benefit from the use of this molecule.
Evaluation of treated municipal wastewater effluent for agricultural irrigation purposes using the fuzzy effluent quality index (FEQI)
Authors: Alihosseini Seyed Hesam , Torabian Ali , Semiromi Farzam Babaei 
Published: October 2019

Abstract
The issues of freshwater scarcity in arid and semi-arid areas could be reduced via treated municipal wastewater effluent (TMWE). Artificial intelligence methods, especially the fuzzy inference system, have proven their ability in TMWE quality evaluation in complex and uncertain systems. The primary aim of this study was to use a Mamdani fuzzy inference system to present an index for agricultural application based on the Iranian water quality index (IWQI). Since the uncertainties were disregarded in the conventional IWQI, the present study improved this procedure by using fuzzy logic and then the fuzzy effluent quality index (FEQI) was proposed as a hybrid fuzzy-based index. TMWE samples of the Gheitarie wastewater treatment plant in Tehran city recorded from 2011 to 2017 were taken into consideration for testing the ability of the proposed index. The results of the FEQI showed samples categorized as ‘Excellent’ (21), ‘Good’ (10), ‘Fair’ (4), and ‘Marginal’ (1) for the warm seasons, and for the cool seasons, the samples categorized as ‘Excellent’, ‘Good’ and ‘Fair’ were 17, 18 and 1, respectively. Generally, a comparison between the IWQI and proposed model results revealed the FEQI's superiority in TMWE quality assessment.
ANTICANCER ACTIVITY OF ZINC OXIDE AND ZINC OXIDE/CADMIUM SULFIDE NANOCOMPOSITES
Authors: JASIM MAKKAWI ALI JABBAR , AYSA NOOR HADI , G GASSIM FATTIMA-ALZAHRA 
Published: October 2019

Objective: The objective of this study is to investigate the anticancer activity of zinc oxide (ZnO) and ZnO/cadmium sulfide (CdS) nanoparticles (NPs). These NPs were active index against five human tumor cell lines, namely hepatocellular carcinoma, mammary gland (MCF-7), epidermoid carcinoma (HEP2), colorectal carcinoma (HCT-116), and rhabdomyosarcoma (RD).
Methods: ZnO and ZnO/CdS NPs were synthesized using zinc acetate dihydrate and oxalic acid. The samples are characterized by Fourier-transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and atomic force microscopy (AFM).
Results: The results were indicated that these NPs can be used to made drug delivery system depending on ZnO and ZnO/CdS nanocomposites for its potential role in enhancing the anticancer efficacy of doxorubicin as well as work on reducing side effects.
Conclusions: ZnO and ZnO/CdS nanocomposites can be used anticancer for five human tumor cells.
PHYTOCHEMICAL SCREENING AND ANTIOXIDANT ACTIVITY OF ECLIPTA ALBA L.
Authors: M Thenmozhi , M JAYANTHI 
Published: October 2019

Objective: Earlier various studies on pharmacological and therapeutic properties of Eclipta alba L. have been reported. The present investigation is on phytochemical screening and antioxidant activity of E. alba L. using different solvent extracts.
Method: The shade-dried and grounded E. alba L. plant materials were treated with petroleum ether, chloroform, ethyl acetate, ethanol, methanol, and water (aqueous) solvents. The extracted residue was then dissolved in dimethylsulfoxide and further used for phytochemical screening and antioxidant studies.
Results: E. alba L. on different solvent extract, the extractive yield was higher in methanol (14.22±0.99% w/w). The phytochemical screening analysis showed high number of secondary metabolites in the aqueous extract compared to other solvent studied. The metabolite flavonoids, phenols, and tannins are likely to be antioxidant potential compound. Hence, further, the total flavonoid content determination showed high of 0.875±0.020 μg/g in methanol extract. Further antioxidant property of E. alba L. was studied by method such as1,1-diphenyl-2-picrylhydrazyl radical scavenging activity, nitric oxide scavenging activity, metal chelating activity, and superoxide dismutase activity which showed high antioxidant potency with IC50 values of 62.76±0.63 μg/ml, 96.24±0.34 μg/ml, 72.29±0.61 μg/ml, and 108.40±0.52 μg/ml, respectively, in the petroleum ether extract.
Conclusion: From the present study, the substantiate result of antioxidant studies has been obtained from petroleum ether extract . Furthermore the extractive value and flavonoid content was observed to be high in methanol extract. The antioxidant potency of E. alba L. was found to be high in petroleum ether extract compared to other solvent studied.
FALSE DIAGNOSIS IS A THREAT - A CASE STUDY
Authors: RP JAYASWAL 
Published: October 2019

Objective: To explore the possibility of false diagnosis and threat to health.
Methods: In the present study, a case history of 23-year–old lactating woman was taken. Seventy-two test parameters were examined at SRL Lab Gurugram and Thyrocare Mumbai on alternative days from different location under variable climatic and family environment.
Results: The tests report of SRL lab was abnormal in range in compare to the reports of Thyrocare Lab.
Conclusion: The present study is expected to attract the attention of people who may be in the position of acquiring health services. In such approach, incidence of false-positive laboratory reports either due to technical errors or patient own conditions is thought to misguide a clinician who may prescribe wrong medicines to the patient. This type of mistake may invite unwanted and life-threatening threats to the patients’ body if inappropriate or wrong drugs are given to the patient. Through this study, it is now suggested to be cautious and should verify before taking any drugs suggested by clinicians. Once a diagnosis is confirmed and considered repeatedly, the development of adverse health effects due to unwanted drugs can be minimized.
Keywords: Diagnosis, Treatment, Drugs, Laboratory reports.
EVALUATION OF ANTIOXIDANT, ANTIMICROBIAL, AND ANTIFUNGAL POTENTIAL OF CUCURBITA PEPO VAR. FASTIGATA SEED EXTRACTS
Authors: RS SONI ROSHNI , BALI MANOJ 
Published: October 2019

Objective: The current study aims to study the antioxidant and antimicrobial and antifungal potential of the methanolic extract of Cucurbita pepo var. fastigata seeds (MECS).
Methods: Extraction of the seeds has been carried out with solvents of increasing polarity (chloroform, acetone, and methanol) and the phytochemical study of the methanolic extract have been carried out using standard methods. The free radical scavenging activity of all the extracts was evaluated by DPPH and H2O2 methods. Standard disk diffusion method was used to evaluate antibacterial and antifungal activities.
Results: Phytochemical evaluation showed the maximum presence of triterpenoids, phenolic compounds, tannins and small amount of Coumarins. Methanolic extract revealed momentous antioxidant activity as compared to chloroform and ethyl acetate extract. Hence, methanolic extract of C. pepo. seeds (MECS) at a dose level of 100, 200 and 300 μg/ml was evaluated for antioxidant potential. Maximum free radical scavenging activity of methanolic seed extract of cucurbita pepo var. fastigata has been found at a dose of 300 μg/ml to be 63±0.16 % by 1,1-diphenyl-2-picryl hydrazyl model and at a value of 78% at 300 μg/ml with H2O2 model. Methanolic extract also showed the presence of antibacterial activity.
Conclusion: Presence of phytochemicals in the methanolic extract is responsible for the antioxidant potential. Extracts were investigated for antibacterial activity using the standard disc diffusion assay method against Bacillus subtilis, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa and for the antifungal activities against Aspergillus niger and Candida albicans. The seed extract showed the presence of antibacterial activity, but the antifungal activity was found to be absent in the extract.
ANTI-HELICOBACTER PYLORI ACTIVITY AND IMMUNOSTIMULATORY EFFECT OF OLIGOSACCHARIDE ISOLATED FROM AVERRHOA CARAMBOLA L.
Authors: W KAPFO , JB CHAUHAN 
Published: October 2019

Objective: The main goals of the study were to isolate oligosaccharide as a secondary metabolite from indigenous fruit, Averrhoa carambola L. (star fruit), and analyze its anti-Helicobacter pylori and immunostimulatory potential.
Methods: The oligosaccharide (S3W) isolated using adsorption chromatography was partially characterized using tandem mass spectrometry in atmospheric pressure chemical ionization/electron spray ionization (APCI/ESI) positive and negative mode and nuclear magnetic resonance. The use of microtiter well method determined anti-H. pylori activity in the form of percentage inhibition of microbial growth, while the determination of the immunostimulatory potential of S3W implemented a protection of DNA, buccal cells, and macrophages against damage by oxidant and N-nitroso-N- methylurea (MNU) and percentage splenocyte proliferative potential.
Results: S3W was a (1→2) β-heptaglucosaccharide with (4→6) α-branching at every second residue. APCI/ESI-positive mode showed B and A fragmentation patterns, while the negative mode showed abundance of A and C fragments. Anomeric hydrogen displayed integration values at 4.8 and 4.2 ppm indicating the presence of α-glucopyranose and β-glucopyranose. The compound protected DNA from oxidant-induced fragmentation. It expressed anti-H. pyloric activity with an IC50 value of 10.71 μg/ml. At 20 μg/ml, S3W protected buccal cells and macrophages significantly from damage due to oxidants and MNU carcinogens, while >50% splenocyte proliferation was induced as compared to that of an untreated control group.
Conclusion: Our studies constitute the first report on the significant immunostimulatory activity of the oligosaccharide isolated from star fruit. The study, thus, supports its application as a therapeutic potential in curbing gastric diseases caused by H. pylori.
EFFECTIVENESS OF VAGINAL CONE THERAPY ON URINARY INCONTINENCE AMONG WOMEN IN SAVEETHA MEDICAL COLLEGE HOSPITAL, THANDALAM, CHENNAI
Authors: J JAGADEESWARI , S KALABARATHI , P MANGALAGOWRI 
Published: October 2019

Objectives: The present aims to assess the level of urinary incontinence in experimental and control group, to assess the effectiveness of vaginal cone therapy on urinary incontinence in experimental group and control group and to associate the post-test level of urinary incontinence with the selected demographic variables among women in the experimental group.
Methods: A quantitative quasi-experimental research design was conducted among 60 women with urinary incontinence. Convenience sampling technique was used. Semi-structured interview method was used to collect the demographical data and level of urinary incontinence among women was assessed by urinary incontinence diagnosis questionnaire.
Results: Among 60 samples in experimental group 26 women had a moderate level of urinary incontinence, and 4 women had slight urinary incontinence whereas in control group 24 women had moderate level of urinary incontinence and 6 women had slight urinary incontinence. The study results show significant improvement in level of urinary incontinence among experimental group than the control group after the intervention at the level of p<0.05. This reveals that vaginal cone therapy is highly significant in the experimental group because pelvic muscle strength had improved and allows the patient to increase the physiological consciousness and promotes the muscle tone after the use of a vaginal cone.
Conclusion: This study proves that vaginal cone therapy is the effective non-pharmacological method, cost-effective method and had no side effects which can be used to treat female urinary incontinence.
SYNTHESIS OF SILVER NANOPARTICLES USING MORINGA OLEIFERA SEEDS, GLYCYRRHIZA GLABRA STEMS, AND ITS ANTI-METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS ACTIVITY
Authors: KALUGENDO ELISA , P KOUSALYA 
Published: October 2019

Objective: The present study focused on synthesizing silver nanoparticles (AgNO3) using Moringa Oleifera seeds and Glycyrrhiza glabra stems.
Methods: The synthesized AgNO3 were used to evaluate the antibacterial efficacy of methicillin-resistant Staphylococcus aureus (MRSA) by agar well diffusion method. AgNO3 were produced from silver nitrate using M. oleifera seeds and G. glabra stems.
Results: AgNO3 were characterized using UV-visible spectroscopy at a wavelength of 400–460 nm. AgNO3 from G. glabra stems showed high anti- MRSA activity with 32 mm zone of inhibition, and M. oleifera seed extract showed 30 mm inhibition zone of inhibition against MRSA.
Conclusion: The biologically synthesized AgNO3 can be used against MRSA.
A STUDY OF METHOD DEVELOPMENT, VALIDATION AND FORCED DEGRADATION FOR SIMULTANEOUS QUANTIFICATION OF CABOZANTINIB AND NIVOLUMAB IN BULK AND PHARMACEUTICAL DOSAGE FORM BY RP-HPLC
Authors: K GOPINATH , M YANADIRAO , Y PAVANI , RAO M SUBBA 
Published: October 2019

Objective: The present paper describes a simple, accurate, and precise reversed-phase high-performance liquid chromatography (HPLC) method for rapid and simultaneous quantification of cabozantinib (CZT) and nivolumab (NVM) in bulk and pharmaceutical dosage form.
Methods: The chromatographic separation was achieved on Luna C18 (150 mm×4.6 mm, 3.5 μm). Mobile phase contained a mixture of 0.1% orthophosphoric acid and acetonitrile in the ratio of 50:50 v/v, flow rate 1.0 ml/min, and ultraviolet detection at 222 nm.
Results: The proposed method shows a good linearity in the concentration range of 20–300 μg/ml for CZT and 5–75 μg/ml for NVM under optimized conditions. Precision and recovery study results are in between 98 and 102%. In the entire robustness conditions, percentage relative standard deviation is <2.0%. Degradation has minimum effect in stress condition and solutions are stable up to 24 h.
Conclusion: This method is validated for different parameters such as precision, linearity, accuracy, limit of detection (LOD), limit of quantification (LOQ), ruggedness, robustness, and forced degradation study were determined according to the International Conference of Harmonization (ICH) Q2B guidelines. All the parameters of validation were found to be within the acceptance range of ICH guidelines. Since there is no HPLC method reported in the literature for the estimation of CZT and NVM in pharmaceutical dosage forms, there is a need to develop quantitative methods under different conditions to achieve improvement in sensitivity, selectivity, etc.
The author declares the interest to develop a validation and forced degradation for simultaneous quantification of CZT and NVM.
VIRTUAL SCREENING OF HETEROCYCLIC COMPOUNDS AGAINST ANGIOTENSIN-CONVERTING ENZYME FOR POTENTIAL ANTIHYPERTENSIVE INHIBITORS
Authors: LOBO C ZOZIMUS DIVYA , MOHAMED A SYED , SHANMUGAM GNANENDRA 
Published: October 2019

Objective: The objective of this study was to investigate the antihypertensive activity of heterocyclic compounds against angiotensin-converting enzyme (ACE) through molecular docking studies.
Methods: The X-ray crystal three-dimensional (3D) structure of human ACE complexed with lisinopril (PDB ID: 1O86) was retrieved from protein databank. The two-dimensional structures of 10 selected heterocyclic compounds were drawn in ACD-Chemsketch and converted into 3D structures. The 3D structures of compounds were virtually screened in the binding pockets of ACE using FlexX docking program. Further, the chemical entities revealing the molecular electronic structures of the best docked compound (Compound-4) were explored through density functional theory studies.
Results: The Compound-4 showed the highest docking score of −26.6290 kJ/mol with ACE. The Hbond and non-bonded interactions are favored by phenylalanine, leucine, and arginine. The energy gap of 1.60 eV between highest occupied molecular orbital and lowest unoccupied molecular orbitals explained the presence of strong electron-acceptor group. Furthermore, the molecular electrostatic potential studies clearly envisaged the requirement of electropositive and electronegative groups are crucial for the ACE inhibitor activities.
Conclusion: The identification of good ACE inhibitors requires the understanding of the current ACE inhibitors. Thus, the docking interactions of Compound-4 and its molecular electronic structure significantly imply its potential as antihypertensive agent. However, further clinical studies are required to ascertain its potential toxic effects.
CYTO-DEPRESSIVE POTENTIAL OF GANODERMA LUCIDUM, PLEUROTUS OSTREATUS AND THEIR BINARY COMBINATIONS AGAINST MERISTEMATIC CELLS OF ALLIUM CEPA L.
Authors: UDDIN PK MOYEN 
Published: October 2019

Objective: The current study is designed to evaluate the cyto-depressive effects of Ganoderma lucidum (GL) and Pleurotus ostreatus (PO) and their binary amalgams (GL+PO) on meristematic cells of Allium cepa L.
Methods: Experiments were assessed by utilizing A. cepa bioassay.
Results: Onion knobs were exposed to 500 μg/mL, 1000 μg/mL, and 2000 μg/mL groupings of the concentrates for naturally visible and minute examination. The concentrates essentially repressed the root development of A. cepa L. contrasted with the control in a period of treatment and concentration-dependent manner (p<0.05). In addition, photomicrographs revealed chromosomal aberrations extending from c-mitosis, stickiness, and bridges in the root tip meristematic cells of A. cepa. All mushroom extracts demonstrated remarkable cyto-depressive impacts on meristematic cells of A. cepa L. with some changeability.
Conclusion: In view of the results come out, GL and PO could be considered as potential sources of anticancer mixes. Notwithstanding, additionally thinks about are essential for disengagement and portrayal of the bioactive mixes and more examination on their pharmacological properties is required. It is first report in Bangladesh where we studied cyto-depressive role of edible mushrooms, Ganoderma lucidum (GL) and Pleurotus ostreatus (PO).
DEVELOPMENT, CHARACTERIZATION, AND EVALUATION OF SELEGILINE BIONANOSUSPENSIONS USING BUCHANANIA LANZAN AS BIOSTABILIZER
Authors: TYAGI YOGITA , MADHAV N. V. SATHEESH 
Published: October 2019

Objective: Development and evaluation of selegiline-loaded bio-nanosuspensions using biopolymer which was isolated from seeds of Buchanania lanzan (Chironji), used as biostabilizer and compared with standard polymer.
Methods: The selegiline-loaded bio-nanosuspensions were prepared using novel biopolymer and standard stabilizer (hydroxypropyl methylcellulose) by sonication solvent evaporation method with different ratios (1%, 2%, 3%, 4%, and 5%) and evaluated for particle size, polydispersity index, zeta potential, pH stability studies, percentage entrapment efficacy, in vitro drug release, and stability studies.
Results: The prepared selegiline bio-nanosuspensions were subjected to the best formulation based on comparison of above-mentioned evaluation parameters, so Fb2 (2%) formulation was found to be the best formulation showing an R2=0.9842, T50% of 32 h and T80% of 70 h, respectively. According to the release kinetics, the best fit model was found to be Peppas-Korsmeyer with Fickian diffusion (Higuchi matrix) as the mechanism of drug release, and Fs5 (5%) formulation was found to be the best formulation showing an R2=0.9564, T50% of 25 h and T80% of 60 h, respectively. According to the release kinetics, the best fit model was found to be Peppas-Korsmeyer with Fickian diffusion (Higuchi matrix) as the mechanism of drug release. The biopolymer provided excellent stability for the formulation and resulting particle size for the best formulation was found to be 360 nm. The best formulation was found to be polydispersity index of 0.43 with zeta potential of −5.12 mV.
Conclusion: The prepared bio-nanosuspensions using biopolymer were found to be safe and compatible with the novel drug delivery for the treatment of depression in comparison of standard polymer.