bluuebunny/crossref_metadata_2025_split huggingface dataset:
Internal control instruments in the accounting policy of public sector entities
Authors: Kanapickienė Rasa 
Published: September 2020

The main legal issues regarding internal control of a public legal entity are regulated by the Law of Internal Control and Internal Audit of the Republic of Lithuania (LR) which designates that one of the aims of internal control is to ensure the reliability and completeness of information and reports. The main regulatory enactments of accounting determine many instruments of internal control which must be ensured by the accounting policy adopted in a public sector entity. Regulatory enactments cover different spheres, i.e. accounting and internal control. These spheres are closely interrelated; therefore, it is important to examine the interrelations between the accounting policy and internal control system.
The object of the research is internal control instruments in the accounting policy of public sector entities.
The aim of the research is to examine the regulation of internal control instruments by legal acts with regard to the accounting policy of a public sector entity.
The article provides the analysis of the accounting organization instruments and internal control instruments of accounting technique which are regulated by the Law of Accounting of LR (2001) and the Law of Public Sector Accountability of LR (2007). The paper systematizes the internal control instruments of accounting policy.
Clusterization of reasons for bankruptcy of enterprises
Authors: Giriūnas Lukas , Mackevičius Jonas , Valkauskas Romualdas 
Published: September 2020

Bankruptcies of enterprises are among the most common events in the market economy. They cause a lot of negative effects not only for the company and its employees, but also for other companies and institutions, the state and society.
Although the researchers have examined the reasons for bankruptcy, there is no list of the signs clearly indicating the likelihood of bankruptcy. Or such list is impossible due to the fact that causes of bankruptcy are related to the complex and constantly changing external environment of the company. That is why various features are only the symptoms pointing to the fact that the company is in danger of going bankrupt. It should be mentioned that some signs indicate that the company may face a number of difficulties, including bankruptcy, if the company’s management will not take appropriate action to eliminate causes of bankruptcy or to adjust to them. Reasons for bankruptcy can be divided into: 1) internal, 2) external. External reasons are such reasons that cannot be affected by company’s executives because they do not depend on the executives’ will. Internal reasons are such reasons that depend on the company’s executives and their level of professionalism, initiative, and ability to lead and to make the right decisions. In order to take the lowest risk, company’s analysts should monitor and investigate all internal and external causes. As it has been already mentioned, there are many internal and external reasons for companies’ bankruptcy but it is not clear which are the most important ones. To answer this question the authors of this article, on the basis of Lithuanian and foreign scientific research, have compiled a theoretical list and the tree of the internal and external causes of bankruptcy. The tree and its components are improved with clusters of reasons for bankruptcy of enterprises.
MORPHOGENESIS AND PATHOGENESIS REGULATION OF CANDIDA ALBICANS BY PROBIOTIC BACTERIUM – PEDIOCOCCUS ACIDILACTICI
Authors: Rezaie Sassan , Zareshahrabadi Zahra , Zomorodian Kamiar , Pakshir Keyvan , Mehrabani Davood , Nouraei Hasti , Motamedi Marjan , Hashemi Seyed Jamal , Ranjbaran Alireza , Nazemi Ladan , Ahmadikia Kazem 
Published: September 2020

The transition of Candida albicans from yeast to hyphae cause the attachment to epithelial cells, forming biofilm and invasion. Therefore, the effect of Pediococcus acidilactici on morphogenesis and pathogenesis of C. albicans were examined. Inhibitory activity of P. acidilactici on Candida species growth was investigated and inhibition of C. albicans biofilm formation was measured by XTT method. Also, expression of seven genes as: Agglutinin-like protein 1 (ALS1,3), hyphal cell-wall protein (HWP1), secreted aspartyl proteinase (SAP4,6), Enhanced filamentous growth 1 (EFG1) and Enhanced activated protein 1 (EAP1) were studied by RT-PCR with different concentrations of P. acidilactici. The experimental activity of this probiotic bacterium was evaluated in an animal model by culture and histopathological methods. P. acidilactici inhibited the growth of Candida species at concentrations of 8-512 µg/mL (approximately 8 × 106 to 5 × 108 CFU/ml). This probiotic bacterium inhibited the germ tube and biofilm formation in a dose-dependent manner. RT-PCR analysis showed a reduction in genes expression. The P. acidilactici reduced the CFUs in mice receiving this probiotic bacterium. Histopathological analyses showed that Candida colonization was diminished in mice following the administration of probiotic. Since the wide range of antifungal activity of this bacterium bacterium, it can be used to manage oral candidiasis.
MRI essentials in epileptology: a review from the ILAE Imaging Taskforce
Authors: Wang Irene , Bernasconi Andrea , Bernhardt Boris , Blumenfeld Hal , Cendes Fernando , Chinvarun Yotin , Jackson Graeme , Morgan Victoria , Rampp Stefan , Vaudano Anna Elisabetta , Federico Paolo 
Published: September 2020

AbstractMagnetic resonance imaging (MRI) plays a central role in the management and evaluation of patients with epilepsy. It is important that structural MRI scans are optimally acquired and carefully reviewed by trained experts within the context of all available clinical data. The aim of this review is to discuss the essentials of MRI that will be useful to health care providers specialized in epilepsy, as outlined by the competencies and learning objectives of the recently developed ILAE curriculum. This review contains information on basic MRI principles, sequences, field strengths and safety, when to perform and repeat an MRI, epilepsy MRI protocol (HARNESS‐MRI) and the basic reading guidelines, and common epileptic pathologies. More advanced topics such as MRI‐negative epilepsy, functional MRI and diffusion‐weighted imaging are also briefly discussed. Although the available resources can differ markedly across different centers, it is the hope that this review can provide general guidance in the everyday practice of using MRI for patients with epilepsy.
El Sırtında Kutanöz Layşmanya ile Karışan Bazal Hücreli Karsinom: Bir Olgu Sunumu
Authors: SEÇİNTİ İlke Evrim , KASTAL Ümmü Gülsüm 
Published: September 2020

Bazal
hücreli karsinom derinin en sık görülen kanseridir ancak el sırtında nadir
görülür. En sık klinik prezentasyonu nodüler ve ülsere lezyonlar
şeklindedir. Layşmanya ise enfekte tatarcıklardan
bulaşan paraziter bir hastalıktır. En sık açıkta kalan cilt bölgelerinde
görülür ve klinik prezentasyonlarından biri de ülseronodüler lezyondur. Türkiye
özellikle de Güneydoğu Anadolu ve Çukurova bölgeleri layşmanya açısından
endemiktir. Tedavileri birbirinden çok
farklı olan bu iki hastalık klinik olarak birbiriyle karışabilmektedir. Biz
klinik olarak yanlış tanı konularak layşmanya tedavisi uygulanan el sırtı
yerleşimli bazal hücreli karsinom olgusu sunduk.
Lumbal Spinal Stenoz Şiddetinin Ağrı, Günlük Yaşam Aktivitesi ve Kas Aktivasyonu Üzerine Etkisi
Authors: ZİLELİ Ahu , ÇANKAYA Tamer 
Published: September 2020

Özet
Lumbal Spinal Stenoz Şiddetinin Ağrı, Günlük Yaşam Aktivitesi ve Kas Aktivasyonu Üzerine Etkisi
Amaç: Bu çalışmanın amacı lumbal spinal stenoz (LSS) tanısı konmuş bireylerde stenöz şiddetinin ağrı, günlük yaşam aktivitesi ve kas aktivasyonu üzerine etki edip etmediğini araştırmaktı.
Yöntemler: Çalışmaya yaş ortalaması 55.19 ±10.41 (yıl) olan 48 LSS tanısı konmuş birey dahil edildi. Bireyler Manyetik Rezonans’da dural kese alanı incelenerek LSS şiddetlerine göre hafif, orta ve ağır olmak üzere 3 gruba ayrıldı. Bireylerin ağrı değerlendirmesi istirahat ve aktivite sırasında vizüel analog skala (VAS) ile, kas aktivasyonu değerlendirmesi Rektus Femoris, Biseps Femoris, Tibialis Anterior ve Gastroknemius kasının medial başından maksimum istemli kontraksiyon sırasında ve yürüme esnasında yüzeyel elektromiyografi (yEMG) ile, günlük yaşam aktivite yeterliliği Oswestry Bel Özürlülük İndeksi (ODI) ile ölçüldü.
Bulgular: LSS şiddetine göre VAS ve ODI (hafif-orta stenoz, hafif-ağır stenoz, orta-ağır stenoz) parametrelerinde anlamlı farklılıklar bulundu (p
Exercise Serum Alters Genes Related Mitochondria in Cardiomyocyte Culture Cell
Authors: Lesmana Ronny , Prasetyo Wibowo Budi , Ray Hamidie Ronald Daniel , Tarawan Vita Murniati , Goenawan Hanna , Setiawan Iwan , Pratiwi Yuni Susanti , Juliati Nova Sylviana , Supratman Unang 
Published: September 2020

Exercise-induced hearth muscle adaptation is important for physiological process after exercise. This adaptation will ensure basal mitochondrial homeostasis and as a part of the mitochondria quality control. This process is reflected by equal level of biogenesis stimulation and as well as the selective degradation of old and undesirable mitochondria through fusion or fission cycle and Mitophagy. There is limited information about genetic regulation stimulated by training in cardiomyocytes. We believe there is a specific myokines or protein release in the serum and initiate cardiac muscle adaptation process. In the present study, twelve male wistar rats were appointed to two group: sedentary control and aerobic-intensity (AE, 15m/minute). Rats were trained for running with specific protocol as follows: 30 minutes/day with a 5 times/week interval for 8 weeks. On the last day, serum form control and exercise groups were taken via retro-orbital sinus. Then, 3.105 H9C2 cells (Rat cardiomyocytes cell line) were cultured and incubated by this serum for 24 hours. After treatment, cell were extracted using trisure for RNA purification and continue with reverse transcriptase PCR. Our data showed that expression of the Pgc-1α, Mfn1, Mfn2, Opa1, Drp1, Pink, and Parkin genes were altered and modulated. Specifically, Mfn1, Mfn2, and Opa1 gene expression levels significantly increased. Interestingly, we did not find significant modulation for Pgc-1α, Drp1, Pink, and Parkin. Taken together, serum of exercise rats might be contained with myokines or specific protein which was released during training and it altered mitochondrial genes expression in cardiomyocytes culture cell. We believe that myokines release in the serum had a contribution in cardiacmyocyte adaptation.
Neurotracker Training to Improve The Archery Athlete Concentration
Authors: Komarudin K , Sagitarius S , Sartono Hadi , Awaludin Patriana Nurmansyah 
Published: September 2020

Neurotracker is a 3D technology with Multiple Object Tracking (MOT). This technology has not been developed in Indonesia. Meanwhile, developed countries have implemented this technology in sport training, including in archery sport. In archery sport, the athletes are required to concentrate every time they perform a technique and to be fast and accurate in making a decision when aiming and releasing the arrows. The problem usually occurs during shooting is that the athlete doubts in aiming and releasing the arrows, thus the shooting result does not hit the target. It is caused by the athlete’s doubt and the lack of concentration. To overcome the problem, a neurotracker training is important to be conducted in every training process to improve the athletes’ concentration. The method used in this study was an experimental method. The samples were 20 persons chosen in a non-random sampling. The subjects were divided into two groups through a random assignment, thus the number of subject in each group was ten persons. The instrument to measure the concentration was the Concentration Grid Test. The design of the study was pretest-posttest control group design. To analyze the data, t-test was used. The result of the study showed that (1) there was a significant effect of the NeuroTracker training on the improvement of the archery athlete’s concentration, (2) there was a significant effect of conventional training on the improvement of archery athlete’s concentration, (3) there was a significant difference of effect between the NeuroTracker training and conventional training in the improvement of the archery athlete’s concentration. The NeuroTracker training was better than a conventional training in increasing the archery athlete’s concentration. It is suggested that the archery trainers implement the NeuroTracker technology in the training process as it could improve the concentration of the archery athletes.
Evaluating Adherence to Medical Therapy in Patients with Chronic Heart Failure: Design and First Results of the COMPLIANCE Study
Authors: Martsevich S. Yu. , Guseynova E. T. , Kutishenko N. P. , Lukina Yu. V. , Tolpygina S. N. , Voronina V. P. , Blagodatskih S. V. 
Published: September 2020

Aim. To study the adherence of doctors to the guidelines for the treatment of chronic heart failure (СHF) and the adherence of patients with СHF to the therapy prescribed by doctors.Material and methods. The COMPLIANCE study is an integral part of the PROFILE registry of the specialized cardiology division of the research center. The study includes patients with verified CHF who were previously observed in the PROFILE registry and patients with CHF who have been newly seeking medical care in the period from December 01, 2019 to December 31, 2020. At the first visit, the initial therapy was evaluated, treatment adherence was determined, and treatment was corrected in accordance with current guidelines. The second visit will also assess patient adherence to treatment, assess the factors of non-adherence and complications of diseases during the year of follow-up.Results. The first 30 case-records of patients with CHF included into the study were analyzed. 90% of patients received angiotensin-converting enzyme inhibitors (ACEI)/angiotensin receptor blockers (ARB). Beta-blockers (BB) were prescribed to 96.7% of patients, and mineralocorticoid receptor antagonists (MRAs) – to 76.7% of patients, and some of them received MRAs at ejection fraction >35%. It was found that the overall adherence of patients according to the adherence scale of the Russian National Society of Evidence-Based Pharmacotherapy (NSEPh) was significantly lower than the adherence to specific drugs. The worst was adherence to ACEI (71%) and MRAs (77%), higher – to BB (86%). The most common factors of non-adherence to treatment, according to the first results, are a large number of medications and a complex medication regimen.Conclusion. The first part of the COMPLIANCE study showed a relatively good adherence of doctors to current guidelines. However, the choice of the drug and its doses did not always correspond to evidence-based medicine data, existing guidelines and summary of product characteristics (SmPC) of specific drugs. The patients adherence to the prescribed therapy was not bad (this can be explained by long-term follow-up in specialized centers), but it was different for different drugs. The worst adherence was registered to the ACEI/ARB. This is warning factor, since these drugs make a significant contribution to improving the long-term outcome of CHF.
The Ecological Balance of Nature: Identifying Stasis and Growth in Late Cretaceous Planktonic Foraminifera from ODP Hole 690C (Weddell Sea)
Authors: Buzas Martin A. , Hayek Lee-Ann C. , Huber Brian T. 
Published: September 2020

ABSTRACT
The ecological balance of nature is defined as an equilibrium between species richness (S) and species evenness (E) such that diversity (H) remains constant with time. Based on this definition, our approach identifies growth or decline in communities as perturbations from stasis and has successfully done so for benthic foraminiferal communities. Here, we examine whether this approach is appropriate for planktonic foraminifera. To do so, we utilized planktonic foraminiferal counts (39 samples, 66% recovery) from Maastrichtian sediments in the Weddell Sea from ODP Hole 690C. A total of 24 species were observed and both &gt;63-µm and &gt;150-µm fractions were counted. In the &gt;63-µm fraction, nine communities were recognized while in the &gt;150-µm fraction, there were 12. In both fractions at 70.45 Ma, a boundary was recognized and immediately after this boundary, a community in growth was identified. A trend of increasing diversity upcore was substantiated by regression on individual samples. For our purposes, the &gt;150-µm fraction in this data set is sufficient to recognize community trends. The &gt;150-µm fraction in Hole 690C has 82% of the sampling time in stasis and an average time per community is 0.85 Ma. The &gt;63-µm fraction has 73% of the sampling time in stasis and an average time per community of 1.02 Ma.
A Sand-Arch Stability Constrained Dynamic Fractal Wormhole Growth Model for Simulating Cold Heavy-Oil Production with Sand
Authors: Yu Haisheng , Leung Juliana Y. 
Published: September 2020

Summary
Cold heavy-oil production with sand (CHOPS) is a nonthermal primary process that is widely adopted in many weakly consolidated heavy-oil deposits around the world. However, only 5 to 15% of the initial oil in place is typically recovered. Several solvent-assisted schemes are proposed as follow-up strategies to increase the recovery factor in post-CHOPS operations. The development of complex, heterogeneous, high-permeability channels or wormholes during CHOPS renders the analysis and scalability of these processes challenging. One of the key issues is how to properly estimate the dynamic growth of wormholes during CHOPS. Existing growth models generally offer a simplified representation of the wormhole network, which, in many cases, is denoted as an extended wellbore. Despite it being commonly acknowledged that wormhole growth due to sand-arch failure is likely to follow fractal statistics, there are no established workflows to incorporate sand-arch stability constraints into the construction of these fractal wormhole patterns.
A novel dynamic wormhole growth model is developed to generate a set of realistic fractal wormhole networks during the CHOPS operations. It offers an improvement to the diffusion limited aggregation (DLA) algorithm with a sand-arch stability criterion. The outcome is a fractal pattern that mimics a realistic wormhole growth path, with sand-arch failure and fluidization being controlled by sand-arch stability constraints. The fractal pattern is updated dynamically by coupling compositional flow simulation on a locally refined grid and a stability criterion for the sand arch: the wormhole would continue expanding following the fractal pattern, provided that the pressure gradient at the tip exceeds the limit corresponding to a sand-arch stability criterion. Important transport mechanisms including foamy oil (nonequilibrium exsolution of gas) and sand-arch failure are integrated.
Public field data for several CHOPS fields in Canada are used to examine the results of the dynamic wormhole growth model and flow simulations. For example, the sand production history is used to estimate a practical range for the critical pressure gradient representative of the sand-arch stability criterion. The oil and sand production histories show good agreement with the modeling results.
In many CHOPS or post-CHOPS modeling studies, constant wormhole intensity is commonly assigned uniformly throughout the entire domain; as a result, the ensuing models are unlikely to capture the complex heterogeneous distribution of wormholes encountered in realistic reservoir settings. This work, however, proposes a novel model to integrate a set of statistical fractal patterns. The entire workflow has been readily integrated with commercial reservoir simulators, enabling it to be incorporated in practical field-scale operations design.
Upregulation of miR-205 induces CHN1 expression, which is associated with the aggressive behaviour of cervical cancer cells and correlated with lymph node metastasis
Authors: liu jianbing , li yunfeng , chen xihua , xu xiangbo , zhao haoqi , wang shufang , hao jianqing , he bin , liu shuyan , wang jiedong 
Published: September 2020

Abstract
Background: Cervical cancer is the leading cause of cancer-related death in women worldwide. However, the mechanisms mediating the development and progression of cervical cancer are unclear. In this study, we aimed to elucidate the roles of microRNAs and a1-chimaerin (CHN1) protein in cervical cancer progression. Methods: The expression of miR-205 and CHN1 protein was investigated by in situ hybridisation and immunohistochemistry. We predicted the target genes of miR-205 using software prediction and dual luciferase assays. The expression of mRNAs and proteins was tested by qRT-PCR and western blotting respectively. The ability of cell growth, migration and invasion was evaluated by CCK-8 and transwell. Cell apoptosis was analysed by flow cytometry analysis. Results: We found that miR-205 and CHN1 were highly expressed in human cervical cancer tissue compared with paired normal cervical tissues. The CHN1 gene was shown to be targeted by miR-205 in HeLa cells. Interestingly, transfection with miR-205 mimic upregulated CHN1 mRNA and protein, while miR-205 inhibitor downregulated CHN1 in high-risk and human papilloma virus (HPV)-negative human cervical cancer cells in vitro,. These data suggested that miR-205 positively regulated the expression of CHN1. Furthermore, the miR-205 mimic promoted cell growth, apoptosis, migration, and invasion in high-risk and HPV-negative cervical cancer cells, while the miR-205 inhibitor blocked these biological processes. Knockdown of CHN1 obviously reduced the aggressive cellular behaviours induced by upregulation of miR-205, suggesting that miR-205 positively regulated CHN1 to mediate these cell behaviours during the development of cervical cancer. Furthermore, CHN1 was correlated with lymph node metastasis in clinical specimens.Conclusions: Our findings showed that miR-205 positively regulated CHN1 to mediate cell growth, apoptosis, migration, and invasion during cervical cancer development, particularly for high-risk HPV-type cervical cancer. These findings suggested that dysregulation of miR-205 and subsequent abnormalities in CHN1 expression promoted the oncogenic potential of human cervical cancer.