bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Vitex agnus in lowering prolactin level in mammary tumor induced SD rats
Authors: Kour Maninder , Megur Ramakrishna Bhat Kumar , Nithyanandamadom Anatharaya Vinodini , Chakraborty Shrijeet , Kumara Chandra Reshma 
Published: December 2020

Introduction and Aim: Breast cancer accounts for about 30% of all cancers in women. The present study aims to see the role of prolactin and Vitex agnus fruit extract in breast cancer progression in mammary tumor induced Sprague Dawley (SD) rats.
Materials and Methods: Thirty-day old inbred SD female rats of body weight 70-80 grams were taken for this study. The rats were induced with N- Methyl-Nitroso-Urea for mammary tumor development. After the development of palpable and visible tumor the rats were treated with anti-prolactin drug (Cabergoline) and a prolactin lowering herb Vitex agnus Castus (VAC) for two months. After the treatment the rats were sacrificed for antioxidants estimation and histopathological section examination.
Results: The rats treated with anti-prolactin drug showed benign tumors with hyperplasia and lactational change proving the presence of prolactin in the tumor tissue, whereas the plant extract showed mammary tumor regression by the presence of foamy macrophages in the histopathological sections. Results also showed treatment with cabergoline increased the GSH level and decreased the MDA level compared to tumor induced group.
Conclusion: Prolactin may have a potential role in progression of breast cancer and Vitex agnus extract showed a prolactin lowering effect and facilitated in regression of the tumor.
La difusión de la investigación científica en Perú: Implicaciones en la educación superior.
Authors: Barrutia Barreto Israel , Acosta Roa Erika Raquel , Quipuscoa Silvestre Manuel , Huaranga Rivera Herbert Víctor 
Published: December 2020

Objetivo. Este estudio se plantea explorar la producción de los investigadores peruanos, analizando el estado de sus publicaciones y su impacto en la educación superior. Método. Se analizará la actuación de las publicaciones peruanas en los bancos de información de Scimago Journal & Country Rank Country Rank, a través del número de citas, el índice H de Hirsh y el Factor de Impacto, conjuntamente con los datos aportados por el Reglamento de calificación, clasificación y registro de los investigadores RENACYT. El procesamiento de la información se realizó mediante tablas, gráficos y el análisis estadístico descriptivo de la información recopilada. Resultados. Los resultados evidencian que las publicaciones del país han mostrado una tendencia favorable al crecimiento, sin embargo al compararse con otros países de la región su actuación es moderada y lenta, situación que influye notoriamente en los parámetros establecidos en el Reglamento de calificación, clasificación y registro de los investigadores RENACYT. Conclusiones Este panorama impacta sobre la redefinición de la investigación científica en la educación superior, ya que a través de la aplicación del Reglamento de calificación, clasificación y registro de los investigadores RENACYT se espera elevar el nivel del investigador, introduciendo cambios que afectan de manera directa a los docente quienes deben cumplir una serie de estrictos requisitos para poder ser catalogados como investigadores.
Tecnologia assistiva em dispositivos móveis: aplicativos baseados no TEACCH como auxílio no processo de alfabetização com crianças autistas
Authors: Reis Marlene Barbosa de Freitas , Souza Carla Salomé Margarida de , Dos Santos Lilian Cristina 
Published: December 2020

Progressivamente emerge a necessidade de redimensionar práticas pedagógicas que, para além do respeito às diferenças, ofereça acessibilidade de aprendizagem a todos os discentes. Uma escola com metodologias conservadoras, dificilmente conseguirá bons resultados diante da educação inclusiva, colocando os discentes com deficiências em condições de exclusão, dentro da própria escola. Percebe-se que no redimensionamento dessas práticas, a Tecnologia Assistiva (TA) assume papel primordial, pois visa a superação de barreiras para a aprendizagem e independência na vida social de indivíduos com deficiências ou outras condições que geram necessidades especiais. Isso fomentou a inquietação que deu origem a este estudo: de que forma a Tecnologia Assistiva associada à Tecnologia Móvel em smartphones e tablets pode contribuir com a aprendizagem, mais especificamente com a alfabetização de crianças com Transtorno do Espectro Autista (TEA) na escola regular? Para responder a essa inquietação, desenvolveu-se uma pesquisa de cunho bibliográfico em autores como: bell hooks (2013), Reis et. al. (2017), Ferreira (2016), Cunha (2017), Furtado (2012), Fonseca e Ciola (2016), Mello (2007), Berch (2007), entre outros. Este artigo apresenta um dos principais métodos educacionais utilizado na educação de crianças autistas, o TEACCH, e faz um levantamento dos usos desse método em dispositivos móveis. Os resultados apontam para a contribuição de dois aplicativos (Lina Educa e ABC Autismo) que podem ser utilizados como ferramentas pedagógicas no processo de aprendizagem de crianças com TEA, auxiliando a inclusão dessas crianças, principalmente no tocante ao processo de alfabetização.
Atributos químicos de latossolos amarelos em áreas de ocorrência da Soja Louca II na Região Oeste do Pará
Authors: Gaspar Avner Brasileiro dos Santos , Silva Rodrigo da 
Published: December 2020

A dinâmica dos nutrientes no solo é resultado da interação de vários fatores, e, no SPD, os mecanismos que governam são modificados em velocidade e/ou intensidade pela redução do revolvimento do solo e manutenção dos resíduos culturais na superfície do solo. Anomalias em plantas relacionadas a solo são diretamente ligadas aos níveis críticos e tóxicos dos atributos físico, químico ou biológicos de solo, logo, a fertilidade do solo é um dos fatores de predisposição das plantas aos patógenos. A soja louca-II é uma anomalia que causa cerda 40% perdas em lavouras e sem causa definida. Objetivo do foi avaliar os teores e variância dos atributos químicos de solos em áreas de com ocorrência da Soja Louca II. Realizaram-se 180 amostras em 20 cm, 40cm e 60cm de profundidas em áreas com e sem a ocorrência da anomalia em propriedades nos municípios de Santarém, Belterra e Mojui dos Campos na região oeste do Pará Os Atributos químicos Ph, P, K, Na, Ca, Mg, Al, Fe, Cu, Zn, Mn e CTC e Teor de Argila natural foram submetidos a análise descritiva e análise de variâncias no programa Biostat versão 5.3. Não foram encontras diferenças significativas entre os atributos nos tratamentos, sendo consideradas estatisticamente semelhantes as áreas com e sem ocorrência da Soja Louca II, porem com terrores de micronutriente em níveis tóxicos na maior parte das amostras em ambos os tratamentos em todas as profundidades coletadas. Os atributos que apresentaram maior e menor Coeficiente de Variação foram pH ( 7.45%) e Zn (198.17% ) a 20cm, pH (6,66%) e Cu (250,70%) a 40cm e pH (5,84%) e Cu (238,74%) a 60m de profundidade. A análise de variância dos atributos químicos não apresentou diferenças significativa entre as profundidades.
Tillid i socialt arbejde
Authors: Matthiessen Annemette , Rask Lisbeth 
Published: December 2020

Artiklen handler om hvordan socialarbejdere kan nuancere og professionalisere deres tillidsarbejde i mødet med borgere. Feltets aktører forstår typisk tillid i socialt arbejde i et hverdagsperspektiv. Det kan være problematisk, da det indebærer en risiko for at afkoble tillidsarbejde fra det sociale systems kontekst og vilkår.
Artiklen gengiver fund fra en undersøgelse af kommunale børne- og ungesagsforløb, hvor forældres oplevelse og håndtering af tillid i socialt arbejde analyseres, og på den baggrund diskuterer vi socialarbejders tilgang til tillid. Vigtige elementer for socialarbejderen i et udviklende tillidsarbejde er at forstå både borgeres og egne forudsætninger for tillid og at skabe en balance mellem hverdags- og systemperspektiver. Der er fokus på forståelse og handleperspektiver både hos den enkelte socialarbejder og i arbejdspladsens fællesskaber.
Métier, savoirs et élèves : l’étrange casse-tête des nouveaux enseignants de formation professionnelle au Québec1
Authors: Beaucher Chantale 
Published: December 2020

Les enseignants de formation professionnelle au Québec se distinguent de leurs collègues d’autres secteurs (Descheneaux, Monette et Tardif, 2012) par le fait qu’ils ont exercé pendant plusieurs années un métier avant de l’enseigner. Ils abordent en outre la carrière en enseignement sans formation initiale en pédagogie. Leur rapport au savoir (Charlot, 1997) s’appuie souvent sur une certaine tension avec l’institution scolaire et ce qu’elle représente (Beaucher, 2014) ainsi que sur la valorisation des savoirs techniques, concrets ou liés à l’exercice de leur métier. Engagés simultanément dans trois processus exigeants de transition entre le métier et l’enseignement, d’insertion professionnelle en enseignement et d’intégration à l’université, ils s’appuient d’abord sur ce qui leur est le plus familier : leur métier et leur expérience d’élève. Le texte soulève des questions éthiques posées par l’entrelacs de quatre pôles identitaires (expert de métier, enseignant, ancien élève et étudiant) occupés simultanément par les participants.
Les rapports aux experts et aux expertes scientifiques de futures enseignantes du primaire interprétés sous l’angle des postures déficitaire, non déficitaire et antidéficitaire
Authors: Groleau Audrey , Pouliot Chantal 
Published: December 2020

Dans une recherche doctorale, nous avons construit une typologie de rapports aux experts et aux expertes scientifiques (rapports de dépendance, de coexistence, de coopération et d’empowerment) de futures enseignantes du primaire (Groleau, 2017). Dans cet article, nous interprétons ces rapports à la lumière des postures déficitaire, non déficitaire et antidéficitaire que les participantes entretiennent face aux citoyens et aux citoyennes. Certaines entretiennent une posture déficitaire, en ce sens qu’elles considèrent que les citoyens et citoyennes souffrent d’un déficit de connaissances, de compréhension ou d’intérêt relatif aux technosciences. D’autres participantes expriment une posture non déficitaire envers eux. D’autres encore veillent à combattre la posture déficitaire : elles entretiennent une posture antidéficitaire. Nous montrons enfin comment les rapports aux experts scientifiques s’arriment avec chacune de ces trois postures et discutons des conséquences de ces résultats sur la prise en compte des aspects éthiques des controverses sociotechniques dans les classes de technosciences.
L’initiation à l’épistémologie des sciences à l’école : peut-on envisager d’autres conceptualisations que le modèle Nature of science (NOS)?
Authors: Hasni Abdelkrim , Bousadra Fatima , Dumais Nancy 
Published: December 2020

Au sein du monde anglophone, l’expressionNature of science(NOS), qui prédomine largement dans les travaux issus du domaine, est présentée comme une « vision consensuelle ». Récemment, cette « vision consensuelle » a été remise en question par de nombreux auteurs. Notre article s’inscrit dans ce mouvement de conceptualisation de l’initiation à l’épistémologie des sciences à l’école. Nous y exposons, dans une première partie, les principales caractéristiques utilisées pour définir la NOS, tout en soulignant ses apports et ses limites, puis nous poursuivons, dans une deuxième partie, par une présentation des principales reconceptualisations proposées. Dans une troisième partie, nous présentons notre proposition de l’initiation à l’épistémologie, fondée sur l’engagement des élèves dans des pratiques scientifiques scolaires et des pratiques épistémiques. Nous concluons l’article en ouvrant la discussion sur les considérations éthiques associées à l’initiation à l’épistémologie en sciences.
Modernity and Progress: The Transnational Politics of Suffrage in British Columbia (1910-1916)
Authors: Campbell Lara 
Published: December 2020

Canadian historians have underplayed the extent to which theproject of suffrage and first wave feminism was transnational in scope. The suffrage movement in British Columbia provides a good example of the global interconnections of the movement. While BC suffragists were relatively uninterested in pan-Canadian campaigns they explicitly situated provincial suffrage within three transnational relationships: the ‘frontier’ myth of the Western United States, radical direct action by suffragettes in the United Kingdom, and the rise of modern China. By the second decade of the 20thcentury, increasingly confident women’s suffrage societies hosted international visits and contributed to global print culture, both of which consolidated a sense of being part of a modern, international and unstoppable movement.
BC suffragists were attuned to American suffrage campaigns in California, Oregon and Washington, which granted female suffrage after referenda and situated political rights for settler women in the context of Western progress narratives. The emphasis on progress and modernity intersected with growing connections to non-Western countries, complicating racialized arguments for settler women’s rights to vote. BC suffragists were particularly impressed by the role of feminism in Chinese political reform and came to understand Chinese women as symbolizing modernity, progress, and equality. Finally, the militant direct action in the British suffrage movement played a critical role in how BC suffragists imagined the role of tactical political violence. They were in close contact with the militant WSPU, hosted debates on the meaning of direct action, and argued that suffragettes were heroes fighting for a just cause. They pragmatically used media fascination with suffragette violence for political purposes by reserving the possibility that unmet demands for political equality might lead to Canadian conflict in the future.
Family Matters: Immigrant Women’s Activism in Ontario and British Columbia, 1960s -1980s
Authors: Little Margaret , Marks Lynne Sorrel , Beck Marin , Paszat Emma , Tom Liza 
Published: December 2020

This article uses oral history interviews to explore the ways in which different attitudes towards family and motherhood could create major tensions between mainstream feminists and immigrant women’s activists in Ontario and British Columbia between the 1960s and the 1980s. Immigrant women’s belief in the value of the family did not prevent immigrant women from going out to work to help support their families or accessing daycare and women’s shelters, hard fought benefits of the women’s movement. However, these women demanded access to job training, English language classes, childcare, and women’s shelters on their own terms, in ways that minimized the racism they faced, respected religious and cultural values, and respected the fact that the heterosexual family remained an important resource for the majority of immigrant women.
Immigrant women activists were less likely to accept a purely gender-based analysis than mainstream feminists. They often sought to work with men in their own communities, even in dealing with violence against women. And issues of violence and of reproductive rights often could not be understood only within the boundaries of Canada. For immigrant women violence against women was often analyzed in relation to political violence in their homelands, while demands for fully realized reproductive rights drew on experiences of coercion both in Canada and transnationally.
Computer-based Training Programs to Stimulate Learning to Read in French for Newcomer Migrant Children: A Pilot Study
Authors: Ecalle Jean , Vidalenc Jean-Luc , Magnan Annie 
Published: December 2020

The integration of newcomer migrant children is a vital challenge for host countries. For such children, learning to read in a new language is a prerequisite for the acquisition of knowledge in all academic domains at school. To investigate this issue, two experiments were conducted: one with children who were just at the beginning of learning to read in French and another with children who could already read a few words in French. Two specific software programs were used for each group. Each group was exposed to the same experimental design, which included three assessment sessions, namely two before training to obtain a baseline of scores in different literacy skills and a third after training to examine the impact of 10 hours of training. In Experiment 1, the alphabetic code was stimulated: a significant effect on phonemic awareness was observed. In Experiment 2, the grapho-syllabic processing required to read words was stimulated: a significant effect on word reading was observed. Our initial results show that teachers can improve learning to read in ways tailored to the needs of newcomer migrant children.
Academic Self-concept in University Students: Their Association with Parents’ Educational Level and Previous Experience in Higher Education
Authors: Gedda Munoz Relmu , Villagrán Del Picò Natalia 
Published: December 2020

The aim of this research is to associate academic self-concept with the educational level of the parents and previous experiences of students in higher education. It is a cross-sectional study that evaluated 1093 students from a private university in Chile. The instruments used were the academic self-concept scale (ASCS), the variables of educational level of the parents and students previous experience in higher education. Bivariate correlations were made using the Spearman coefficient, associations using Pearson’s Chi-Square, and mean difference using the Mann-Whitney U between ASCS with the parents’ educational level and previous experience in higher education. The outcomes indicate correlation, association and mean difference (p < .05) between the ASCS and the educational level of the mother when she has university studies, as well as with the existence of previous experiences in higher education, being the father’s educational level of no significant impact. In conclusion, academic self-concept is greater when students have a mother with university studies and when they have previous experiences in higher education.
Dysregulated levels of glycogen synthase kinase-3β (GSK-3β) and miR-135 in peripheral blood samples of cases with nephrotic syndrome
Authors: Ardalan Mohammadreza , Hejazian Seyyedeh Mina , Sharabiyani Hassan Fazlazar , Farnood Farahnoosh , Ghafari Aghdam Amirhossein , Bastami Milad , Ahmadian Elham , Zununi Vahed Sepideh , Cucchiarini Magali 
Published: December 2020

BackgroundGlycogen synthase kinase-3 (GSK-3β) is a serine/threonine kinase with multifunctions in various physiological procedures. Aberrant level of GSK-3β in kidney cells has a harmful role in podocyte injury.MethodsIn this article, the expression levels of GSK-3β and one of its upstream regulators, miR-135a-5p, were measured in peripheral blood mononuclear cells (PBMCs) of cases with the most common types of nephrotic syndrome (NS); focal segmental glomerulosclerosis (FSGS) and membranous glomerulonephritis (MGN). In so doing, fifty-two cases along with twenty-four healthy controls were included based on the strict criteria.ResultsLevels of GSK-3β mRNA and miR-135 were measured with quantitative real-time PCR. There were statistically significant increases in GSK-3β expression level in NS (P = 0.001), MGN (P = 0.002), and FSGS (P = 0.015) groups compared to the control group. Dysregulated levels of miR-135a-5p in PBMCs was not significant between the studied groups. Moreover, a significant decrease was observed in the expression level of miR-135a-5p in the plasma of patients with NS (P = 0.020), MGN (P = 0.040), and FSGS (P = 0.046) compared to the control group. ROC curve analysis approved a diagnostic power of GSK-3β in discriminating patients from healthy controls (AUC: 0.72,P = 0.002) with high sensitivity and specificity.ConclusionsDysregulated levels of GSK-3β and its regulator miR-135a may participate in the pathogenesis of NS with different etiology. Therefore, more research is needed for understanding the relationship between them.
Characterization of DNA methylation in Malawian Mycobacterium tuberculosis clinical isolates
Authors: Ndhlovu Victor , Kiran Anmol , Sloan Derek J. , Mandala Wilson , Nliwasa Marriott , Everett Dean B. , Kumwenda Benjamin , Mwapasa Mphatso , Kontogianni Konstantina , Kamdolozi Mercy , Corbett Elizabeth , Caws Maxine , Davies Gerry 
Published: December 2020

Background
Although Mycobacterium tuberculosis (Mtb) strains exhibit genomic homology of >99%, there is considerable variation in the phenotype. The underlying mechanisms of phenotypic heterogeneity in Mtb are not well understood but epigenetic variation is thought to contribute. At present the methylome of Mtb has not been completely characterized.

Methods
We completed methylomes of 18 Mycobacterium tuberculosis (Mtb) clinical isolates from Malawi representing the largest number of Mtb genomes to be completed in a single study using Single Molecule Real Time (SMRT) sequencing to date.

Results
We replicate and confirm four methylation disrupting mutations in 4 lineages of Mtb. For the first time we report complete loss of methylation courtesy of C758T (S253L) mutation in the MamB gene of Indo-oceanic lineage of Mtb. Additionally, we report a novel missense mutation G454A (G152S) in the MamA gene of the Euro-American lineage which could potentially be attributed to total disruption of methylation in the CCCAG motif but partial loss in a partner motif. Through a genomic and methylome comparative analysis with a global sample of sixteen, we report previously unknown mutations affecting the pks15/1 locus in L6 isolates. We confirm that methylation in Mtb is lineage specific although some unresolved issues still remain.
Coworking Spaces in Germany during the Covid-19 Crisis Utilized for Homeoffice and Homeschooling
Authors: Gruenwald Hermann 
Published: December 2020

Aims: To capture the perception of coworking space (CWS) users during the covid-19 crisis for homeoffice and homeschooling purposes in terms of process, physical evidence and people components of the service marketing mix.
Study Design: This is a grounded theory study in nature which explores the users’ perceptions of coworking spaces.
Place and Duration of Study: Coworking spaces in Germany during the covid-19 crisis between March 2020 and August 2020.
Methodology: We included 200 respondents (88 male and 112 female; age range 18-88 years) who used the different services of various types of coworking spaces for entertainment, business and or education purposes as employees, entrepreneurs, retirees or students.
Results: Very important for the process are comfort and atmosphere together with cleanliness and safety (Mean 3.48, SD 1.31, r = 0.529). The physical evidence mentioned location in terms of access and the facility itself (Mean 3.54, SD 1.11, r = 0.650). People (Mean 3.31, SD 1.27, r = 0.619) make the CWS function with management, staff and customer mix.
Conclusion: Coworking spaces received a big boost during the covid-19 crisis after initial lockdown and will continue to grow in the New Normal with homeoffice and on-line learning becoming the norm while CWS focus on process, physical evidence and people components of their marketing mix.