bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Simple Technique for Endoscopic Hypothalamic Hamartoma Disconnection in Refractory Epilepsy: 2-Dimensional Operative Video
Authors: Budke Marcelo , Pérez-Jiménez María Ángeles , Mena-Bernal José Hinojosa 
Published: April 2020

Abstract
Hypothalamic hamartomas often cause refractory epilepsy, best controlled with surgery. A transcallosal interforniceal approach provides good outcomes although it has resulted in some complications including fornix lesions with transitory and permanent memory losses.
1-2
Endoscopic disconnection is less invasive, avoids interhemispheric approach, callosotomy and fornix as well as propagation of epileptic discharges.
3,4
Laser disconnection does not allow objective measurement of the vaporized tissue and can cause significant hypothalamic edema. We demonstrate a simple hypothalamic disconnection endoscopy technique using the VarioGuide frameless stereotactic system (Brainlab, Germany), bipolar coagulation electrode (Karl Storz, Germany), and 3-French Fogarty catheter (Edwards Lifesciences, USA).
We present a 12-yr-old right-handed girl who developed normally until 4 yr old when gelastic seizures began. Antiepileptic drugs and gamma knife radiosurgery did not control the seizures. Magnetic resonance imaging showed a nodular 13 mm left hypothalamic mass protruding into the third ventricle. The patient consented to surgery.
We used a rigid 30° 6-mm neuroendoscope (Aesculap, Germany) with VarioGuide to reach the ventricle. After visualizing the foramen of Monro, the bipolar coagulation electrode perforated holes along the hamartoma/hypothalamus interface. The Fogarty balloon catheter was inserted into each hole and gently inflated to connect the holes and disconnect the mass from the hypothalamus.
The patient's postsurgical recovery was excellent, presenting intact short- and long-term memory without neurological deficit or endocrine complications. She continues seizure-free 2 yr after surgery. We have successfully used this technique in 4 more cases and, if results continue to be good, will consider it a useful tool for these infrequent malformations.
Open Door Laminoplasty – Hinge Creation and Fracture Avoidance: 2-Dimensional Operative Video
Authors: Guinn Jeremy M V , Mayer Rory , Chou Dean 
Published: April 2020

Abstract
This surgical video demonstrates a technique for an open-door laminoplasty with its associated risks.
1-3
The key to maintaining a strong hinge that can be opened without fracture lies in gradual, slow drilling of the hinge followed by sequential, progressively wider opening of the laminoplasty. This is in contradistinction to a single opening maneuver, which “cracks” the hinge and can result in fracture and disconnection of the lamina from the spine. We present our technique of C4-6 right-sided open-door laminoplasty. A C3 laminectomy is performed instead of a laminoplasty in order to prevent any muscular dissection of C2. This not only maintains the strong muscular attachment to C2, but it also helps alleviate postoperative pain since the muscles are maintained.
4-6
The top of C7 is drilled to decompress the C6-7 level, and the C7 spinous process, along with its strong attachment to T1, is maintained to prevent kyphosis. The video highlights methods for maintaining key muscular and ligamentous attachments (C2 muscles and C7-T1 ligament) to decrease kyphosis risk, progressive hinge opening to help mitigate the risk of hinge fracture, and methods to help decrease postoperative pain (avoiding laminoplasty of C3, maintaining muscular and ligamentous attachments as stated above, and contouring the spinous processes in a manner that avoids protrusion into the paraspinal muscles). We have received informed consent of this patient to submit this video.
Neonatal hypoglycemia and the CPT1A P479L variant in term newborns: A retrospective cohort study of Inuit newborns from Kivalliq Nunavut
Authors: Collins Sorcha A , Hildes-Ripstein Gertrude Elizabeth , Thompson James Robert , Edmunds Sharon , Miners Amber , Rockman-Greenberg Cheryl , Arbour Laura 
Published: April 2020

AbstractIntroductionNeonatal hypoglycemia (NH) in the first days of life can largely be prevented by recognizing those at risk and managing accordingly. The CPT1A P479L variant is prevalent in northern Indigenous populations and is a possible risk factor for hypoglycemia. We report on NH incidence in the Kivalliq region of Nunavut, where all Inuit newborns are screened for NH.MethodsWe reviewed clinical charts of 728 Inuit newborns from Kivalliq (January 1, 2010 to December 31, 2013) for blood glucose (BG) levels and infant/maternal characteristics, linking to CPT1A genotype; 616 newborns had BG data from 2 to 48 hours of life. NH was defined using Canadian Paediatric Society guidelines (≤2.0 mmol/L at 2 hours, &lt;2.6 mmol/L at 2 to 48 hours).ResultsNH was documented in 21.4% overall, 24.4% of at-risk newborns and 19.5% of term newborns with no risk factors (≥37 weeks gestation, term-NRF). NH was documented in 22.0% of CPT1A P479L homozygous, 19.8% of P479L heterozygous and 4.8% of noncarrier term-NRF newborns. With multivariable logistic regression, the adjusted ORs for developing NH in term-NRF newborns was 4.97 for CPT1A P479L homozygotes (95% confidence interval [CI]:0.65–38.35, P=0.19) and 4.71 for P479L heterozygotes (95% CI:0.57–37.89, P=0.15).ConclusionTerm-NRF newborns had a higher NH incidence than previously reported, similar to that for at-risk newborns, possibly due to the CPT1A P479L variant. Since only Inuit newborns from Kivalliq are screened for NH, further study of long-term outcomes of NH in this population and the role of the P479L variant are warranted to determine if neonatal BG screening is indicated in all Inuit newborns.
Effects of adding liquid lactose or molasses to pelleted swine diets on pellet quality and pig performance
Authors: Dunmire Kara M , Wickersham Tryon A , Frenzel Leslie L , Sprayberry Sarah R , Joiner Logan C , Hernandez Lily P , Cassens Andrew M , Dominguez Brandon , Paulk Chad B 
Published: April 2020

Abstract
Two experiments were conducted to evaluate the effects of including liquid lactose (LL) and molasses (M) in swine diets on pellet quality and pig performance. In experiment 1, a total of 194 nursery pigs (DNA 241 × 600, initially 6.7 ± 0.4 kg at 27 d of age) were used in a 33-d experiment evaluating the effects of LL (SweetLac 63; Westway Feed Products, Tomball, TX) or cane molasses on nursery pig performance and pellet quality. Pelleted experimental diets were fed from d 0 to 21, and a common pelleted diet fed from d 21 to 33. Dietary treatments consisted of a control diet containing 19.1% total sugars from whey powder and whey permeate and experimental diets with a percentage of whey permeate replaced by either 5% or 10% LL or 9.4% cane molasses (5 LL, 10 LL, and 9.4 M, respectively). Hot pellet temperature and production rate decreased (P &lt; 0.05) from the control to 9.4 M treatments with 5 LL and 10 LL having intermediate effects. Pellet durability index (PDI) increased (P &lt; 0.05) in 5 LL, 10 LL, and 9.4 M, respectively. From d 0 to 7, pigs fed the 10 LL and 9.4 M treatment had the best G:F followed by the control and 5 LL treatments. From d 0 to 21, ADFI had a marginally significant improvement (P &lt; 0.10) in pigs fed up to 10 LL in the diet. Fecal consistency scores at d 7 were also firmer (P &lt; 0.05) in pigs fed 9.4 M compared with pigs fed the control or 5 LL treatments with pigs fed the 10 LL treatment being intermediate. There was no evidence for differences in fecal consistency scores for d 14. In experiment 2, a total of 289 finishing pigs (DNA 241 × 600; initially 53.5 ± 0.5 kg BW) were used in a 53-d experiment evaluating the effects of LL on pellet quality and finishing pig performance. Experimental diets were fed in pelleted form from d 0 to 53 divided into three phases. Dietary treatments were a corn-soybean meal control diet with 0%, 2.5%, 5%, and 7.5% LL added in the place of corn. PDI improved (linear, P &lt; 0.01) with increasing inclusion of LL. There were no differences in ADG, ADFI, final BW, or carcass characteristics. Pigs fed diets with increasing levels of LL tended to have improved (quadratic, P = 0.070) G:F.
Succinct Dynamic de Bruijn Graphs
Authors: Alipanahi Bahar , Kuhnle Alan , Puglisi Simon J. , Salmela Leena , Boucher Christina 
Published: April 2020

AbstractMotivationThe de Bruijn graph is one of the fundamental data structures for analysis of high throughput sequencing data. In order to be applicable to population-scale studies, it is essential to build and store the graph in a space- and time-efficient manner. In addition, due to the ever-changing nature of population studies, it has become essential to update the graph after construction e.g. add and remove nodes and edges. Although there has been substantial effort on making the construction and storage of the graph efficient, there is a limited amount of work in building the graph in an efficient and mutable manner. Hence, most space efficient data structures require complete reconstruction of the graph in order to add or remove edges or nodes.ResultsIn this paper we present DynamicBOSS, a succinct representation of the de Bruijn graph that allows for an unlimited number of additions and deletions of nodes and edges. We compare our method with other competing methods and demonstrate that DynamicBOSS is the only method that supports both addition and deletion and is applicable to very large samples (e.g. greater than 15 billionk-mers). Competing dynamic methods e.g., FDBG (Crawford et al., 2018) cannot be constructed on large scale datasets, or cannot support both addition and deletion e.g., BiFrost (Holley and Melsted, 2019).AvailabilityDynamicBOSS is publicly available athttps://github.com/baharpan/dynboss.Contactbaharpan@ufl.edu
SARS-CoV-2 neutralizing serum antibodies in cats: a serological investigation
Authors: Zhang Qiang , Zhang Huajun , Huang Kun , Yang Yong , Hui Xianfeng , Gao Jindong , He Xinglin , Li Chengfei , Gong Wenxiao , Zhang Yufei , Peng Cheng , Gao Xiaoxiao , Chen Huanchun , Zou Zhong , Shi Zhengli , Jin Meilin 
Published: April 2020

SummaryCoronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, China, and rapidly spread worldwide. Previous studies suggested cat could be a potential susceptible animal of SARS-CoV-2. Here, we investigated the infection of SARS-CoV-2 in cats by detecting specific serum antibodies. A cohort of serum samples were collected from cats in Wuhan, including 102 sampled after COVID-19 outbreak, and 39 prior to the outbreak. 15 of 102 (14.7%) cat sera collected after the outbreak were positive for the receptor binding domain (RBD) of SARS-CoV-2 by indirect enzyme linked immunosorbent assay (ELISA). Among the positive samples, 11 had SARS-CoV-2 neutralizing antibodies with a titer ranging from 1/20 to 1/1080. No serological cross-reactivity was detected between the SARS-CoV-2 and type I or II feline infectious peritonitis virus (FIPV). Our data demonstrates that SARS-CoV-2 has infected cat population in Wuhan during the outbreak.
Meteorological factors correlate with transmission of 2019-nCoV: Proof of incidence of novel coronavirus pneumonia in Hubei Province, China
Authors: Li Jianfeng , Zhang Linyuan , Ren Zhihua , Xing Caihong , Qiao Peihuan , Chang Bing 
Published: April 2020

AbstractObjectivemany potential factors contribute to the outbreak of COVID-19.It aims to explore the effects of various meteorological factors on the incidence of COVID-19.MethodsTaking Hubei province of China as an example, where COVID-19 was first reported and there were the most cases, we collected 53 days of confirmed cases (total 67773 cases) and ten meteorological parameters up to March 10. Correlation analysis and linear regression were used to judge the relationship of meteorological factors and increment of COVID-19 confirmed cases.ResultsUnder 95% CI, the increment of confirmed cases in Hubei were correlated with four meteorological parameters of average pressure, average temperature, minimum temperature and average water vapor pressure (equivalent to absolute humidity).The average pressure was positively correlated with the increment (r=+0.358).The negative correlations included average temperature (r=-0.306), minimum temperature (r=-0.347), and average water vapor pressure (r=-0.326). The linear regression results show if minimum temperature increases by 1□, the incremental confirmed cases in Hubei decreases by 72.470 units on average.ConclusionStatistically, the incidence of COVID-19 was correlated with average pressure, average temperature, minimum temperature and average water vapor pressure. It is positively correlated with the average pressure and negatively correlated with the other three parameters. Compared with relative humidity, 2019-nCov is more sensitive to water vapor pressure. The reason why the epidemic situation in Hubei expanded rapidly is significantly related to the climate characteristics of low temperature and dryness of Hubei in winter.
Boss was not yet pleased; Did the performance matter?
Authors: Pallikara Rameshan 
Published: April 2020

Learning outcomes
To evaluate a difficult career choice under compelling organizational circumstances. To analyse a complex organizational culture to understand the nuances of career decisions. To relate career dilemmas to relevant conceptual and theoretical strands of organizational behaviour. To interpret the leadership style and its interaction with organizational culture. To determine possible strategic recourses to deal with the dynamics of destructive leadership and toxic cultures.

Case overview/synopsis
The case is about the experiences of Raamit Pell, a Middle-level Executive at Accadia Management Services, and his encounters with a new boss, Pret Sohn. Raamit Pell had joined Accadia at a time when the organization was undergoing some political and cultural turmoil. When Pret Sohn came in as the new Chief Executive Officer six months later, there were a lot of expectations. But, Pret Sohn too began following Accadia’s existing political culture, indulging in unhealthy organizational practices. He caused mental harassment to many executives. One such executive was Raamit Pell. Despite Raamit’s excellent performance, Pret Sohn denied him a well-deserved promotion. Sohn justified it by saying that performance alone did not matter. Raamit felt deeply disturbed and considered quitting Accadia. He was reluctant to leave as a defeated man. Subsequently, he received an offer from another subsidiary of Accadia’s holding agency. As he was undergoing a three-month mandatory notice period for his release, Raamit became concerned about his decision to leave Accadia. Deep in his mind he longed to redeem his hurt pride at Accadia. So, he was pondering whether he had taken the decision to resign in haste.

Complexity academic level
Level: Post-graduate/doctoral and executive education programmes in management and allied subjects. Courses: Courses in Career Decisions, Organizational Behaviour, Leadership, Organizational Culture and Organizational Ethics.

Supplementary materials
Teaching Notes are available for educators only.

Subject code
CSS 7: Management Science.
Business students and work-life: mind the gaps!
Authors: Govender Cookie M. , Vaaland Terje I. 
Published: April 2020

PurposeThis paper aims to identify challenges in business school and business collaboration when implementing work-integrated learning (WIL) as a vehicle to enhance student work-life realities and possible employability opportunities.Design/methodology/approachThis paper adopts a five-step literature synthesis method. In-depth review and analysis of the existing literature of WIL challenges during the period 2009 to 2018 was conducted.FindingsThe literature review revealed five major gaps identified in WIL projects, resulting from a lack of institutional support, mentoring and assessment, student readiness, curriculum relevance and host motivation. These challenges were related to differences or gaps in the business school and business domains. Seven propositions are suggested as a starting point to manage the five gaps when initiating WIL as a successful learning project.Practical implicationsOur syntheses of challenges hampering WIL projects is highly relevant for deepening business school awareness and when planning to launch WIL projects. The paper presents a realistic view on school-business interaction involving WIL students.Originality/valueThe paper contributes by enabling WIL practitioners to gain a systematic overview of WIL challenges and pitfalls. Negative factors impacting on business school and business domains are highlighted in the model and paper propositions. Awareness, mindfulness and avoiding the pitfalls and gaps facing WIL students, schools and participating businesses ensure effective, efficient and successful WIL experiences and projects.
Directors' stress in day care centers: related factors and coping strategies
Authors: Elomaa Mailis , Pakarinen Eija , Eskelä-Haapanen Sirpa , Halttunen Leena , Von Suchodoletz Antje , Lerkkanen Marja-Kristiina 
Published: April 2020

PurposeThis study aims to explore what causes stress to day care center directors and what their coping strategies are. In addition, the study examined the extent to which directors experience work-related stress and burnout, and the factors associated with their work-related stress, engagement and recovery from work.Design/methodology/approachA mixed method approach was used.FindingsThe results showed that the main sources of directors' stress were connected to leading oneself, leading others, managing change and lack of social support. Moreover, the main coping strategies with stress were leading oneself, social support and leading others. In addition, both pre- and in-service leadership training played a significant role in the experience of stress. The nature of factors causing stress and coping strategies with stress may imply that directors need further support in self-management and developing their internal competences.Research limitations/implicationsThe present study has limitations that need to be considered when making generalizations. First, a small sample size limits the generalization of the findings. Second, the study relied solely on one source of information, i.e. directors' self-reports. Third, data were collected only at one time point at the end of the year when stress levels might have accumulated. Finally, the study has been done in the Finnish educational context where day care center directors' job description varies depending on municipality.Practical implicationsThe findings provide important information about the causes of directors' work-related stress as well as their coping strategies and about factors that might be related to those.Social implicationsBecause directors' stress impact on children’s development and well-being through teachers' well-being, it is crucial to pay attention on directors' well-being and provide more support for them.Originality/valueThe current study is among the few ones focusing on the stress of directors at early childhood education (ECE) settings.
Organisational context and behavioural complexity affecting ambidextrous behaviours among SMEs
Authors: Poon Wai Chuen , Mohamad Osman 
Published: April 2020

PurposeThe purpose of this paper is to examine the antecedents of exploitative and explorative behaviours and to give valuable insight into the role of ambidextrous behaviours in developing creativity and innovativeness among owner-managers in SMEs.Design/methodology/approachA review of existing literature was carried out and drawing upon owner-managers, a survey using structured questionnaires was carried out with a total of 183 useful responses received. The proposed model was analysed using SmartPLS v2.3.7.FindingsThe empirical result suggests that behavioural complexity and organisational flexibility encourages exploitative and explorative behaviours, while ambidextrous behaviours encourage creativity and innovativeness. Rigidity, on the other hand, hinders the cultivation of ambidextrous behaviours.Originality/valueThe paper entails useful implication by demonstrating that flexibility enables owner-managers to reconcile competing demands and consequently, cultivate innovative outcomes. In this regard, business owner-managers must learn implicitly how to juggle these contradictory demands, suggesting an internal balancing mechanism independent of the organisational context and individual behavioural complexity. This paper suggests that cultivation of exploitative and explorative behaviours among owner-managers is useful in encouraging ambidextrous behaviours among SMEs.
The management of accounting firms: time as an object of professional and commercial goals
Authors: Loscher Georg Josef , Kaiser Stephan 
Published: April 2020

PurposeThis study aims to explore how commercial and professional management instruments are combined in accounting firms.Design/methodology/approachThe authors conducted a qualitative study based on 30 semi-structured interviews with partners from 30 different accounting firms (sole practitioners to Big Four) in Germany. The study mainly draws from the literature on the management of accounting firms.FindingsThe findings of this study indicate that professional and commercial management instruments structure the use of time by accountants. In these management instruments, professional and commercial goals are interwoven by three mechanisms revealed in this study and named as ambivalence, assimilation and integration. The authors further identify the managerial aspects of professional instruments.Originality/valueThis paper offers three mechanisms that combine commercial and professional goals in the management of accounting firms. The authors thereby contribute to the literature on the management of accounting firms by analysing these mechanisms that enable the pursuit of both goals simultaneously. Further, the authors argue that the minimum organisation, defined by regulators, of accounting firms is an essential infrastructure for the commercialisation of accounting.