bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proposal of a modified subclassification system for stage III colorectal cancer: A multi‐institutional retrospective analysis
Authors: Shinto Eiji , Ike Hideyuki , Hida Jin‐ichi , Kobayashi Hirotoshi , Hashiguchi Yojiro , Hase Kazuo , Kishi Yoji , Ueno Hideki , Sugihara Kenichi 
Published: July 2020

AbstractAimThe prognostic value of the stage III subclassification system based on the Japanese Classification of Colorectal, Appendiceal, and Anal Carcinoma has not yet been clarified. This study aimed to develop a modified system with optimal risk stratification and compare its performance with the current staging systems.MethodsClinicopathological data from 6855 patients with stage III colorectal cancers who underwent D3 dissection were collected from a nationwide multicenter database. After determining patient survival rates across 13 divisions based on pathological N stage (N1, N2a, and N2b/N3) and tumor depth (T1, T2, T3, T4a, and T4b), except for T1N2a and T1N2b/N3 due to the small number, we categorized patients into three groups and developed a trisection staging system according to the Akaike information criterion. We then compared the Akaike information criterion of the developed system with those of the current staging systems.ResultsThe T1N1[rank, 1] division (98.5%) had the most favorable prognosis in terms of 5‐year cancer‐specific survival, followed by T2N1[2] (93.9%), T2N2a[3] (92.0%), T3N1[4] (87.0%), T3N2a[5] (78.8%), T4aN1[6] (78.7%), T2N2b/N3[7] (77.8%), T4aN2a[8] (75.2%), T4bN1[9] (73.5%), T3N2b/N3[10] (64.7%), T4aN2b/N3[11] (61.5%), T4bN2b/N3[12] (43.0%), and T4bN2a[13] (42.5%). Compared to the categorizations of the Japanese and tumor‐node‐metastasis systems (Akaike information criterion, 22 684.6 and 22 727.1, respectively), the following stage categorizations were proven to be the most clinically efficacious: T1N1[1]‐T3N1[4], T3N2a[5]‐T4bN1[9], and T3N2b/N3[10]‐T4bN2a[13] (Akaike information criterion, 22 649.2).ConclusionThe proposed modified system may be useful in the risk stratification of patients with stage III colorectal cancer who had undergone D3 dissection.
The comparison of health‐related quality of life and patient satisfaction between single‐incision and multiport laparoscopic colectomy for cancer: A sub‐study of a randomized, prospective clinical trial
Authors: Ohya Hiroki , Watanabe Jun , Suwa Yusuke , Suwa Hirokazu , Ozawa Mayumi , Ishibe Atsushi , Fujii Shoichi , Kubota Kazumi , Kunisaki Chikara , Endo Itaru 
Published: July 2020

AbstractAimThe present study clarified the effect on the health‐related quality of life and patient satisfaction of single‐incision laparoscopic colectomy compared with multiport laparoscopic colectomy for colorectal cancer.MethodsWe conducted a multicenter, randomized, control trial comparing single‐incision and multiport laparoscopic colectomy for colon cancer. We performed a pre‐planned secondary analysis of health‐related quality of life and patient satisfaction data of 200 patients. Health‐related quality of life was evaluated using the Japanese 36‐item Short Form Health Survey (SF‐36) version 2.0 before surgery and at 1 month after surgery. Patient satisfaction was compared using seven questionnaires at 1 month after surgery.ResultsOne hundred patients were assigned to each group. After excluding 18 patients (9.0%) who did not complete the SF‐36, 182 patients (91.0%) were included in the analysis (92 cases of single‐incision laparoscopic colectomy and 90 cases of multiport laparoscopic colectomy). The SF‐36 scores at 1 month after surgery were not significantly different between the two arms. The role physical, bodily pain, vitality and physical component summary were significantly lower at 1 month after surgery than before in both groups. However, the role emotional was significantly lower after surgery than before only in the single‐incision laparoscopic colectomy group. In terms of patient satisfaction at 1 month after surgery, there were no significant differences in any of the seven items on the questionnaire.ConclusionsSingle‐incision laparoscopic colectomy was similar to multiport laparoscopic colectomy in terms of health‐related quality of life and patient satisfaction. However, single‐incision laparoscopic colectomy may be inferior than multiport laparoscopic colectomy in terms of the role emotional.
The opportunity for outcrossing varies across the geographic range of the primarily selfingClarkia xantianassp.parviflora
Authors: Ruane Lauren G. , Mangum Samantha M. , Horner Kaitlyn M. , Moeller David A. 
Published: July 2020

PremiseThe timing of self‐fertilization has potentially important consequences for the trajectory of mating system evolution, the opportunity for outcrossing, and the maintenance of genetic variation in populations. For primarily selfing taxa, it remains poorly understood as to how floral variation influences the opportunity for outcrossing and whether those attributes vary among populations across geographic ranges.MethodsWe examined variation in floral traits (herkogamy, protandry, flower size, stigma stage at anthesis, timing of stigma receptivity) in seven populations ofClarkia xantianassp.parviflora, a primarily selfing taxon, spanning from the western to eastern margins of its distribution. We also performed experimental emasculations and pollinations (followed by stigma severing) to quantify the extent of opportunities for outcrossing across flower development.ResultsThere was marked among‐population variation in all floral traits, particularly between far eastern and western populations. Emasculation experiments showed that the eastern populations had minimal autonomous selfing, but western populations had high rates of selfing within 24 h after anthesis. Population variation in autofertility was significantly predicted by floral trait variation, especially protandry and petal size.ConclusionsGreater protandry both extended the time over which outcrossing could potentially occur and reduced the probability of autonomous selfing, suggesting that there may be a tradeoff that results in fitness loss when pollinator visits are not common. The east‐west pattern of differentiation in some floral traits parallels that of postglacial range expansion, suggesting that selection on the mating system may have been strong in the process of range expansion.
Knobloch syndrome in a patient from Chile
Authors: Nakousi‐Capurro Nicole , Huserman Jonathan , Castillo Silvia , Herrera Luisa , Romero Pablo , Pizarro Felipe , Quezada Cristian , Cea Francisco 
Published: July 2020

AbstractKnobloch Syndrome (KS) is a rare autosomal recessive hereditary disease. Despite its clinical heterogeneity, it is characterized by vitreoretinal degeneration and high myopia, with or without occipital skull defects. It is caused by mutations in the COL18A1 gene, which codifies for collagen XVIII, present in retina and vascular endothelium. Since the first description of the disease by doctors Knobloch and Layer in 1972, over 100 cases and 20 pathogenic or likely pathogenic mutations have been reported. We present the case of a child born from a consanguineous couple in Chile with congenital high myopia and dysmorphisms without an occipital skull defect. Whole exome sequencing analysis revealed an inherited homozygous variant in COL18A1, c.4224_4225delinsC, p.Pro1411Leufs*35.
Integrating Time‐Resolved Imaging Information by Single‐Luminophore Dual Thermally Activated Delayed Fluorescence
Authors: Luo Mengkai , Li Xuping , Ding Longjiang , Baryshnikov Gleb , Shen Shen , Zhu Mingjie , Zhou Lulu , Zhang Man , Lu Jianjun , Ågren Hans , Wang Xu‐dong , Zhu Liangliang 
Published: July 2020

AbstractThe fact that the lifetime of photoluminescence is often difficult to access because of the weakness of the emission signals, seriously limits the possibility to gain local bioimaging information in time‐resolved luminescence probing. We aim to provide a solution to this problem by creating a general photophysical strategy based on the use of molecular probes designed for single‐luminophore dual thermally activated delayed fluorescence (TADF). The structural and conformational design makes the dual TADF strong in both diluted solution and in an aggregated state, thereby reducing sensitivity to oxygen quenching and enabling a unique dual‐channel time‐resolved imaging capability. As the two TADF signals show mutual complementarity during probing, a dual‐channel means that lifetime mapping is established to reduce the time‐resolved imaging distortion by 30–40 %. Consequently, the leading intracellular local imaging information is serialized and integrated, which allows comparison to any single time‐resolved signal, and leads to a significant improvement of the probing capacity.
Oral surgery with nasotracheal intubation in a patient with ectodermal dysplasia
Authors: Nanegrungsunk D. , Jericho B. G. 
Published: July 2020

SummaryEctodermal dysplasias are a rare group of heritable disorders involving the ectodermal derivatives with only a few published reports involving its anaesthetic management. We present the case of a 16‐year‐old boy with ectodermal dysplasia presented for elective oral surgery under general anaesthesia with a surgeon preference for nasotracheal intubation to provide adequate surgical exposure. The patient had successful nasal flexible bronchoscopic intubation despite challenging tracheal intubation conditions. We summarise previous case reports and discuss anaesthetic considerations in ectodermal dysplasia , including reduced mucus production in the respiratory tract, laryngeal incompetence, potential for difficult tracheal intubation and hyperthermia from reduced or absent sweat glands.
Graphene nanoplatelets composite membranes for thermal comfort enhancement in performance textiles
Authors: Bonetti Lorenzo , Fiorati Andrea , Serafini Andrea , Masotti Guido , Tana Francesca , D'Agostino Agnese , Draghi Lorenza , Altomare Lina , Chiesa Roberto , Farè Silvia , Bianchi Massimiliano , Rizzi Laura Giorgia , De Nardo Luigi 
Published: July 2020

AbstractThe advent of 2D nanostructured materials as advanced fillers for polymer matrix composites has opened the doors to a plethora of new industrial applications requiring both electric and thermal management. Unique properties, in fact, can arise from accurate selection and processing of 2D fillers and their matrix. Here, we report an innovative family of nanocomposite membranes based on polyurethane (PU) and graphene nanoplatelets (GNPs), designed to improve thermal comfort in functional textiles. GNP particles were thoroughly characterized (through Raman, atomic force microscopy, high‐resolution TEM, scanning electron microscope), and showed high crystallinity (ID/IG = 0.127), low thickness (D50 < 6–8 layers), and high lateral dimensions (D50 ≈ 3 μm). When GNPs were loaded (up to 10% wt/wt) into the PU matrix, their homogeneous dispersion resulted in an increase of the in‐plane thermal conductivity of composite membranes up to 471%. The thermal dissipation of membranes, alone or coupled with cotton fabric, was further evaluated by means of an ad hoc system designed to simulate a human forearm. The results obtained provide a new strategy for the preparation of membranes suitable for technical textiles, with improved thermal comfort.
If the archaeological context is missing: the use of LiDAR prospection to uncover features at the medieval Christian position on Malvecino Hill (Alcalá de Henares, Spain)
Authors: Ramírez Galán Mario 
Published: July 2020

AbstractThe ongoing study of the Andalusian castle of Alcalá la Vieja (Alcalá de Henares, Madrid, Spain) continues to provide new insights about this Muslim fortress. However, the investigation of other battlefield locations around this stronghold, such as Malvecino Hill, have remained in the background. As the site where the Christian army built a temporary castle, Malvecino played a decisive role during the siege and conquest of Alcalá la Vieja in 1118 and is a strong candidate for archaeological study.Some early archaeological prospections carried out at Malvecino in the 1970s corroborated the existence of medieval remains. Scholars have debated whether those remains derive from the fortress built by the Christians or to an earlier settlement. Unfortunately, those artefacts and features disappeared and are not available for additional investigation.Given the lack of archeological context, our investigation included the process of locating potential archaeological features in Malvecino Hill using both aerial photography and light detection and ranging (LiDAR) datasets. This article highlights the value of LiDAR prospection as a preliminary step to fieldwork and describes two early medieval structures on Malvecino Hill that were newly revealed by our LiDAR visualization.
An evaluation of parent implemented web‐based behavioral skills training for firearm safety
Authors: Novotny Marissa A. , Miltenberger Raymond G. , Frederick Katelyn , Maxfield Trevor C. 
Published: July 2020

AbstractBehavioral skills training (BST) is effective for teaching safety skills but often requires a behavior analyst to conduct the training, which can make it costly and inaccessible for most parents. Parent‐conducted BST may allow for children to receive training without the need for a trained behavior analyst. Manualized training from a website could allow parents access to needed material at a low cost. This study evaluated a web‐based manualized intervention implemented by parents for teaching firearm safety skills using BST. We used a multiple‐probe across participants design to assess the effectiveness of parent‐conducted BST. Results indicate that three children acquired the safety skills after parent‐conducted BST alone, and the other three children required experimenter‐conducted IST.
Intermittent pneumatic compression versus additional prophylaxis with enoxaparin for prevention of venous thromboembolism after laparoscopic surgery for gastric and colorectal malignancies: multicentre randomized clinical trial
Authors: Kamachi H , Homma S , Kawamura H , Yoshida T , Ohno Y , Ichikawa N , Yokota R , Funakoshi T , Maeda Y , Takahashi N , Amano T , Taketomi A 
Published: July 2020

Abstract

Background
The role of antithrombotic chemoprophylaxis in prevention of venous thromboembolism (VTE) in laparoscopic surgery for gastric and colorectal malignancies is unknown. This study compared the addition of enoxaparin following intermittent pneumatic compression (IPC) with IPC alone in patients undergoing laparoscopic surgery for gastrointestinal malignancy.

Methods
In this multicentre RCT, eligible patients were older than 40 years and had a WHO performance status of 0 or 1. Exclusion criteria were prescription of antiplatelet or anticoagulant drugs and history of VTE. Patients were allocated to IPC or to ICP with enoxaparin in a 1 : 1 ratio. Stratification factors included sex, location of cancer, age 61 years and over, and institution. Enoxaparin was administered on days 1–7 after surgery. Primary outcome was VTE, evaluated by multidetector CT on day 7.

Results
Of 448 patients randomized, 208 in the IPC group and 182 in the IPC with enoxaparin group were evaluated. VTE occurred in ten patients (4·8 per cent) in the IPC group and six (3·3 per cent) in the IPC with enoxaparin group (P = 0·453). Proximal deep vein thrombosis and/or pulmonary embolism occurred in seven patients (3·4 per cent) in the IPC group and one patient (0·5 per cent) in the IPC with enoxaparin group (P = 0·050). All VTE events were asymptomatic and non-fatal. Bleeding occurred in 11 of 202 patients in the IPC with enoxaparin group, and one patient needed a transfusion. All bleeding events were managed by discontinuation of the drug.

Conclusion
IPC with enoxaparin after laparoscopic surgery for gastric and colorectal malignancies did not reduce the rate of VTE. Registration number: UMIN000011667 (https://www.umin.ac.jp/).
Hippocampal circuits underlie improvements in self‐reported anxiety following mindfulness training
Authors: Sevinc Gunes , Greenberg Jonathan , Hölzel Britta K. , Gard Tim , Calahan Thomas , Brunsch Vincent , Hashmi Javeria A. , Vangel Mark , Orr Scott P. , Milad Mohammed R. , Lazar Sara W. 
Published: July 2020

AbstractIntroductionMindfulness meditation has successfully been applied to cultivate skills in self‐regulation of emotion, as it employs the unbiased present moment awareness of experience. This heightened attention to and awareness of sensory experience has been postulated to create an optimal therapeutic exposure condition and thereby improve extinction learning. We recently demonstrated increased connectivity in hippocampal circuits during the contextual retrieval of extinction memory following mindfulness training.MethodsHere, we examine the role of structural changes in hippocampal subfields following mindfulness training in a randomized controlled longitudinal study using a two‐day fear‐conditioning and extinction protocol.ResultsWe demonstrate an association between mindfulness training‐related increases in subiculum and decreased hippocampal connectivity to lateral occipital regions during contextual retrieval of extinguished fear. Further, we demonstrate an association between decreased connectivity and decreases in self‐reported anxiety following mindfulness training.ConclusionsThe results highlight the role of the subiculum in gating interactions with contextual stimuli during memory retrieval and, also, the mechanisms through which mindfulness training may foster resilience.
The freedom within framework: A multilevel perspective on developing green capabilities through routines in service organisations
Authors: Morrow Jeremy , Mowatt Simon 
Published: July 2020

AbstractThe environmental strategy literature accepts that environmental sustainability can be a crucial source of competitive advantage, but approaches based on the resource‐based view require further explanation as to how green capabilities are developed and transmitted and how employees at different levels contribute to these processes. This article examines these processes by investigating three multilevel case studies of New Zealand service industry firms, based on 32 interviews with senior and middle managers and front‐line staff. The study finds that although green routines and green capabilities develop in heterogeneous, path‐dependent and idiosyncratic ways, these follow identifiable processes at the micro level and meso levels of the firm. On the basis of these findings, a framework is developed suggestion pathways explaining how green routines are aggregated into green capabilities across the whole firm, which is termed the freedom within framework.
Perceived behavioral control as a mediator of hotels' green training, environmental commitment, and organizational citizenship behavior: A sustainable environmental practice
Authors: Cop Serdar , Alola Uju Violet , Alola Andrew Adewale 
Published: July 2020

AbstractBy employing a more comprehensive environmental sustainability and behavioral practices and framework, organizations' green human resources, production process among other processes, are also situated at addressing the rising challenge of global warming. To an extent, the gear toward improving the sustainable organization or production entails the environmental sustainability practices, green initiatives, and environmentally friendlier methods against the business‐as‐usual and the traditional patterns. In so doing, the current study is aimed at examining the effect of green training on organizational citizenship behavior and environmental commitment via the mediating role of perceived behavioral control. By applying the theory of planned behavior, this paper also tests the mediating effect of perceived behavioral control in the organization and the environment. Data from 306 employees working in four and five‐star hotels in Istanbul were analyzed using AMOS statistical version 20. The result revealed that green training positively affects environmental commitment and organizational behavior and that perceived behavioral control fully mediates the link. In essence, the investigation equally revealed that it is important to engage employees in environmental sustainability training and related information, especially in compliance with the global drive for the Sustainable Development Goals. The findings and implications of the study are further revealed to serve effective policy tools to organizations, governance, and other stakeholders.
The revision of nonfinancial reporting directive: A critical lens on the comparability principle
Authors: Venturelli Andrea , Pizzi Simone , Caputo Fabio , Principale Salvatore 
Published: July 2020

AbstractThe launch of the European New Green Deal represents a strategic plan developed in Europe to favor the transition to more sustainable business models. One of the main initiative is represented by the revision of the Directive 95/2014/EU. This revision came in response to several criticisms of the directive's application to European Public Interest Entities, including the low degree of comparability that characterize the resulting nonfinancial declarations. This research paper analyzes how 70 Italian PIEs adhere to the comparability principle when preparing their nonfinancial declarations. Furthermore, a difference‐in‐differences analysis has been performed to assess the impacts of Directive 95/2014/EU on nonfinancial declarations' comparability. Our results highlight how the comparability of nonfinancial reports is an objective not yet achieved. In this regard, the revision of Directive 95/2014/EU will represent an opportunity for policymakers to address this critical issue.
Evaluating the impact of universal Lynch syndrome screening in a publicly funded healthcare system
Authors: Lee Petra W. C. , Bedard Angela C. , Samimi Setareh , Beard Vivienne K. , Hong Quan , Bedard James E. J. , Gilks Blake , Schaeffer David F. , Wolber Robert , Kwon Janice S. , Lim Howard J. , Sun Sophie , Schrader Kasmintan A. 
Published: July 2020

AbstractPurposeReferrals for Lynch syndrome (LS) assessment have traditionally been based on personal and family medical history. The introduction of universal screening practices has allowed for referrals based on immunohistochemistry tests for mismatch repair (MMR) protein expression. This study aims to characterize the effect of universal screening in a publicly funded healthcare system with comparison to patients referred by traditional criteria, from January 2012 to March 2017.MethodsPatient files from the time of initiation of universal screening from 2012 to 2017 were reviewed. Patients were sorted into two groups: (a) universally screened and (b) referred by traditional methods. Mutation detection rates, analysis of traditional testing criteria met, and cascade carrier testing were evaluated.ResultsThe mutation detection rate of the universal screening group was higher than the traditionally referred group (45/228 (19.7%) vs 50/390 (12.5%), P = .05), though each were able to identify unique patients. An analysis of testing criteria met by each patient showed that half of referred patients from the universal screening group could not meet any traditional testing criteria.ConclusionThe implementation of universal screening in a publicly funded system will increase efficiency in detecting patients with LS. The resources available for genetic testing and counseling may be more limited in public systems, thus inclusion of secondary screening with BRAF and MLH1 promoter hypermethylation testing is key to further optimizing efficiency.