bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patients With Voice Prosthesis Rehabilitation During the COVID‐19 Pandemic: Analyzing the Effectiveness of Remote Triage and Management
Authors: Longobardi Ylenia , Galli Jacopo , D’Alatri Lucia , Savoia Vezio , Mari Giorgia , Rigante Mario , Passali Giulio Cesare , Bussu Francesco , Parrilla Claudio 
Published: August 2020

ObjectiveTo describe a remote approach used with patients with voice prosthesis after laryngectomy during the COVID‐19 pandemic and the resulting clinical outcomes in terms of voice prosthesis complications management, oncological monitoring, and psychophysical well‐being.Study DesignProspective cohort study.SettingOtolaryngology Clinic of the University Polyclinic A. Gemelli, IRCCS Foundation.Subjects and MethodsAll patients with voice prosthesis who underwent laryngectomy followed by our institute were offered enrollment. Patients who agreed to participate were interviewed to inquire about the nature of the need and to plan a video call with the appropriate clinician. Before and 1 week after the clinician’s call, patients were tested with the Hospital Anxiety and Depression Scale. Degrees of satisfaction were investigated with a visual analog scale. A comparison between those who accepted and refused telematic support was carried out to identify factors that influence patient interest in teleservice.ResultsVideo call service allowed us to reach 37 (50.68%) of 73 patients. In 23 (62.16%) of 37 cases, the video call was sufficient to manage the problem. In the remaining 14 cases (37.83%), an outpatient visit was necessary. Participants who refused telematic support had a significantly shorter time interval from the last ear, nose, and throat visit than patients who accepted (57.95 vs 96.14 days, P =. 03). Video‐called patients showed significantly decreased levels of anxiety and depression (mean Hospital Anxiety and Depression Scale total score pre– vs post–video call: 13.97 vs. 10.23, P <. 0001) and reported high levels of satisfaction about the service.ConclusionRemote approach may be a viable support in the management of patients with voice prosthesis rehabilitation.
Effects of transcranial magnetic stimulation on the performance of the activities of daily living and attention function after stroke: a randomized controlled trial
Authors: Liu Yuanwen , Yin Mingyu , Luo Jing , Huang Li , Zhang Shuxian , Pan Cuihuan , Hu Xiquan 
Published: August 2020

Objective: We aimed to interrogate the effects of transcranial magnetic stimulation (TMS) on the performance in activities of daily living (ADL) and attention function after stroke. Design: Randomized controlled trial. Setting: Inpatient rehabilitation hospital. Subjects: We randomized 62 stroke patients with attention dysfunction who were randomly assigned into two groups, and two dropped out from each group. The TMS group ( n = 29) and a sham group ( n = 29), whose mean (SD) was 58.12 (6.72) years. A total of 33 (56.9%) patients had right hemisphere lesion while the rest 25 (43.1%) patients had left hemisphere lesion. Interventions: Patients in the TMS group received 10 Hz, 700 pulses of TMS, while those in the sham group received sham TMS for four weeks. All the participants underwent comprehensive cognitive training. Main measures: At baseline, and end of the four-week treatment, the performance in the activities of daily living was assessed by Functional Independence Measure (FIM). On the other side, attention dysfunction was screened by Mini-Mental State Examination (MMSE), while the attention function was assessed by the Trail Making Test-A (TMT-A), Digit Symbol Test (DST) and Digital Span Test (DS). Results: Our data showed a significant difference in the post-treatment gains in motor of Functional Independence Measure (13.00 SD 1.69 vs 4.21 SD 2.96), cognition of Functional Independence Measure (4.69 SD 1.56 vs 1.52 SD 1.02), total of Functional Independence Measure (17.69 SD 2.36 vs 5.72 SD 3.12), Mini-Mental State Examination (3.07 SD 1.36 vs 1.21 SD 0.62), time taken in Trail Making Test-A (96.67 SD 25.18 vs 44.28 SD 19.45), errors number in Trail Making Test-A (2.72 SD 1.03 vs 0.86 SD 1.03), Digit Symbol Test (3.76 SD 1.09 vs 0.76 SD 0.87) or Digital Span Test (1.69 SD 0.54 vs 0.90 SD 0.72) between the TMS group and the sham group ( P < 0.05). Conclusions: Taken together, we demonstrate that TMS improves the performance in the activities of daily living and attention function in patients with stroke.
Spiritually Informed Interventions and Psychotic Disorders: A Systematic Review of Randomized Controlled Trials
Authors: Turner Patricia R. , Hodge David R. 
Published: August 2020

Purpose: Including spirituality in the treatment of psychosis is controversial. To determine the effect of incorporating spirituality into treatment, we conducted a systematic review of spiritually informed interventions with persons with psychotic disorders (PPD). Methods: A search of 15 electronic databases was conducted to identify randomized controlled trials that used spiritually informed interventions with PPD. Results: Of 4,317 papers examined, seven studies met eligibility criteria. A narrative review revealed that the use of spiritually informed interventions was significantly associated with positive outcomes across all seven studies. Supplementary quantitative analysis indicated that the use of spiritually informed interventions was associated with significantly and clinically meaningful lower levels of psychosis symptoms (Hedges’s g = 1.06, 95% confidence interval [0.46, 1.66], p = .001). Discussion: The results suggest that social workers and other mental health providers should consider incorporating client spirituality into treatment protocols when working with PPD.
Subtrochanteric rotational osteotomy for young adults with hip pain due to femoral maltorsion
Authors: Rigling Dominic , Zingg Patrick O , Dora Claudio 
Published: August 2020

Introduction: Femoral rotational osteotomies can be a treatment option for symptomatic femoral maltorsion. This study investigated the clinical and radiological results of subtrochanteric rotational osteotomy and its potential adverse effects, particularly on patellofemoral stability and geometry. Methods: Retrospective consecutive series of patients undergoing subtrochanteric rotational osteotomy with hip arthroscopy. 25 hips, 18 with decreased (⩽4°), 7 with increased (⩾28°) femoral torsion (FT), were analysed. Mean follow-up was 37 months. Subjective Hip value (SHV), WOMAC and Harris Hip Score (HHS), hip range of motion, asymmetries in foot position during gait as well as patellofemoral instability were the outcome measures. Femoral and tibial torsion as well as morphological signs of patella maltracking (TTTG, patellar tilt and lateralisation) were measured on MRI. Results: SHV improved from 52% to 72% ( p = 0.002), WOMAC from 3 to 1 ( p < 0.001) and HHS from 68 to 86 ( p < 0.001). Hips treated for reduced FT showed better internal rotation and hips treated for excessive FT less internal rotation compared to the opposite side. 1 patient demonstrated asymptomatic minor in-toeing. Objective patellofemoral instability was not found except for in 1 patient with bilateral patellofemoral apprehension. FT was normalised (mean 16° ± 9°). Tibial torsion showed normal values. Compared to the opposite side TTTG ( p > 0.08), patellar tilt ( p > 0.09) and lateralisation ( p > 0.26) did not differ. No complications occurred. Conclusions: Subtrochanteric rotational osteotomy with hip arthroscopy improves the hip subjectively without leading to objective patellofemoral instability nor changes in the patellofemoral geometry compared to contralateral side. The technique of subtrochanteric rotational osteotomy is safe and reliable.
Are survivors of cardiac arrest provided with standard cardiac rehabilitation? – Results from a national survey of hospitals and municipalities in Denmark
Authors: Tang Lars H , Joshi Vicky , Egholm Cecilie Lindström , Zwisler Ann-Dorthe 
Published: August 2020

Abstract

Aim
To quantify the provision of standard cardiac rehabilitation to Danish survivors of cardiac arrest at a programme level, and to analyse whether organizational factors influenced the provision.

Method
We mapped the provision of cardiac rehabilitation core components to survivors of cardiac arrest and compared this with a reference group of patients after acute myocardial infarction using data from a cross-sectional programme-level survey among all hospitals (n = 34) and municipalities (n = 98) in Denmark. Organizational factors of potential importance to service provision were considered: health care region, size of catchment area/population, type of department/municipality and socioeconomic index.

Results
Response rates for the provision of each core component of cardiac rehabilitation ranged from 64% to 98%. All hospitals and municipalities provided some aspect of cardiac rehabilitation to survivors of cardiac arrest. Across hospitals, provision of four core components of cardiac rehabilitation to survivors of cardiac arrest was lower compared with post acute myocardial infarction patients: patient education (relative risk (RR) = 0.45 (95% confidence interval (CI) 0.27 to 0.75)), exercise training (RR = 0.69 (95% CI 0.49 to 0.98)), screening for anxiety and depression (RR = 0.64 (95% CI 0.46 to 0.90) and nutritional counselling RR = 0.76 (95% CI 0.62 to 0.93)). No difference was found in the provision of core components across municipalities. Overall, the provision of cardiac rehabilitation to survivors of cardiac arrest was not affected by organizational factors

Conclusion
This study indicates a need for future research to inform the development, adoption and implementation of equal access to all components of cardiac rehabilitation for survivors of cardiac arrest in Denmark
Moral distress and occupational wellbeing in audiologists: an Australian case study
Authors: Simpson Andrea , Short Alana M , Malicka Alicja N , Clarke-Errey Sandy 
Published: August 2020

Objective The purpose of this study was to assess if a relationship existed between (i) audiologists’ perceptions of moral distress, (ii) occupational wellbeing, and (iii) patient-practitioner orientation. Design The Moral Distress Thermometer, Health and Safety Executive (HSE) Management Standards Indicator Tool and Patient-Practitioner Orientation Scale (PPOS) was sent out to all audiologists registered with the professional body Audiology Australia. Study sample: A total of 43 audiologists completed the questionnaires. Results Using a multiple linear regression model there was no evidence of a relationship between patient-practitioner orientation and either moral distress or occupational wellbeing. However, an association between higher moral distress and lower occupational wellbeing was demonstrated. The occupational wellbeing subscales of ‘managerial support’, ‘peer support’, ‘relationships’, ‘role’, and ‘change’ were strongly associated with poorer scores on moral distress. Conclusion For our sample of audiologists, ethical conflict appeared to be linked to reduced job satisfaction. There is a need to consider ways of providing supportive organisational structures in which ethical conflicts can be openly discussed and negotiated in order to improve occupational wellbeing in the profession.
“Trikala Quits Smoking”: A Citizen Co-Creation Program Design to Enforce the Ban on Smoking in Enclosed Public Spaces in Greece
Authors: Skerletopoulos Leonidas , Makris Angela , Khaliq Mahmooda 
Published: August 2020

Background: Tolerance and acceptance of smoking indoors by consumers is common in Greece, and for the most part, authorities turn the other cheek in enforcing long-standing legislation banning smoking in enclosed public places. Focus of the Article: This case study describes the “Trikala Quits Smoking” initiative, which was designed to enforce smoking legislation in Trikala, creating a new social norm to counter the national indifference to enforcing the law regarding smoking indoors. Declared a smart city three times since 2009 and considered one of the most digitally progressive cities in the country, Trikala presents a good example of how to achieve behavior change in a high-context culture. This article outlines the processes used and the lessons learned to achieve the long-term goal of protecting adults and children from the effects of indoor second-hand smoking (SHS) by changing perception and acceptance of indoor smoking by the community, business owners, and local government. Program Design/Approach: A citizen co-creation approach was used to design the program to attain community buy-in and change existing social norms. The Socio-Ecological Model guided this process. It engaged upstream, midstream, and downstream stakeholders, including medical professionals, commercial business owners, the municipal leadership, and citizens to initiate the change. The deCIDES framework was used to guide project implementation. Planning for the initiative started in January 2017, with implementation commencing September 2017 and the project ending June 2019. Importance to the Social Marketing Field: This case study is the first documentation of social marketing in Greece. Implementation of this initiative shows the value of social marketing in changing social norms for high-context cultures. Methods: Primary data were gathered using a citizen-orientated information gathering process consisting of open community meetings, closed group stakeholder meetings, and project member meetings. Data from the city council regarding the number of fines issued to businesses provided evidence of the intervention’s success. Results: Before the start of the intervention, less than five percent of businesses were compliant with the law; after implementation, 90% of the businesses were compliant. Over 1,200 inspections took place, and only 50 fines for lack of compliance were issued over 18 months. The initiative was deemed successful in banning smoking in enclosed public spaces and shifting social norms about SHS. In late 2019, a national ban on smoking in enclosed public places was enforced by the newly elected parliament.
Endoscopic treatment of large symptomatic colon lipomas: A systematic review of efficacy and safety
Authors: Bronswijk Michiel , Vandenbroucke Anne‐Marie , Bossuyt Peter 
Published: August 2020

BackgroundVarious techniques have been described for endoscopic resection of large symptomatic colon lipomas. Lipoma unroofing might provide a safer, more time efficient and easier technique compared to dissection‐based techniques, endoscopic mucosal resection (EMR) or loop‐assisted resection. The aim of this systematic review was to compare efficacy and safety (endoscopic resolution rates, clinical remission rates and adverse events) of lipoma unroofing with respect to dissection‐based techniques, EMR or loop‐assisted resection.MethodsAs most outcomes were binary in nature and several outcomes did not occur in some studies, routine calculation of standard errors in outcome probability was not possible. Therefore, original patient data were extracted, after which efficacy and safety were compared.ResultsTwenty four studies met the selection criteria, which encompassed 77 lesions (46.8% female, mean age 63 years (interquartile range (IQR) 53–72 years), mean size 45.4 mm (IQR 30.0–60.0 mm). Ten patients underwent unroofing (13.0%), whereas 7 (9.1%), 31 (40.3%) and 29 patients (37.7%) underwent dissection‐based techniques, EMR and loop‐assisted‐snare resection, respectively. Endoscopic resolution rates were 60%, 100% (p  = 0.103), 93.6% (p  = 0.024) and 93.1% (p  = 0.028). Clinical remission rates were identical in all four groups (100%). Amongst patients who underwent EMR and loop‐assisted techniques, adverse events were identified in 12.9% (p  = 0.556) and 13.8% (p  = 0.556), respectively, compared to none in the unroofing and dissection‐based resection group.ConclusionsIn patients with large colon lipomas, endoscopic treatment by unroofing, dissection‐based resection, EMR and loop‐assisted resection provided similar clinical remission rates. Amongst patients undergoing EMR and loop‐assisted resection, increased endoscopic resolution rates were seen at the expense of more adverse events, although the latter did not reach statistical significance. Until more reliable comparative data are available, the most optimal resection technique should rely on local expertise and patient profile.
Excellent Mathematical Performance Despite “Negative” Affect of Students in Korea: The Values Perspective
Authors: Pang (방정숙) JeongSuk , Seah (佘伟忠) Wee Tiong 
Published: August 2020

Purpose: Given the unclear relationship between cognition and affect, this article reports on a study exploring how the conative variable of values may provide some explanation for students with excellent performance despite a negative attitude toward mathematics. Design/Approach/Methods: The study reported in this article represents Korea's participation in the international “What I Find Important (in my mathematics learning)” [WIFI] study, which assesses the attributes of mathematics learning and teaching that are valued by students. The participants of this study were 816 Korean students who responded to the WIFI questionnaire. Findings: The results of principal component analysis indicated that the following five attributes about mathematics and mathematics pedagogy were valued by Korean students: understanding, connections, fun, accuracy, and efficiency. These attributes were further analyzed with relation to student gender, school system, and student confidence. Originality/Value: Korean students’ valuing of understanding and connections is noteworthy. It is hoped that the findings of this study might explain Korean students’ exceptional performance despite a generally low affective mode, and extending this further, how values in mathematics education might be a useful construct to help us make sense of the observed mismatch globally between high performance and low affect.
A comprehensive review of COVID-19 characteristics
Authors: Esakandari Hanie , Nabi-Afjadi Mohsen , Fakkari-Afjadi Javad , Farahmandian Navid , Miresmaeili Seyed-Mohsen , Bahreini Elham 
Published: August 2020

AbstractIn December 2019, a novel coronavirus, named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) or (2019-nCoV) with unknown origin spread in Hubei province of China. The epidemic disease caused by SARS-CoV-2 called coronavirus disease-19 (COVID-19). The presence of COVID-19 was manifested by several symptoms, ranging from asymptomatic/mild symptoms to severe illness and death. The viral infection expanded internationally and WHO announced a Public Health Emergency of International Concern. To quickly diagnose and control such a highly infectious disease, suspicious individuals were isolated and diagnostic/treatment procedures were developed through patients’ epidemiological and clinical data. Early in the COVID-19 outbreak, WHO invited hundreds of researchers from around the world to develop a rapid quality diagnosis, treatment and vaccines, but so far no specific antiviral treatment or vaccine has been approved by the FDA. At present, COVID-19 is managed by available antiviral drugs to improve the symptoms, and in severe cases, supportive care including oxygen and mechanical ventilation is used for infected patients. However, due to the worldwide spread of the virus, COVID-19 has become a serious concern in the medical community. According to the current data of WHO, the number of infected and dead cases has increased to 8,708,008 and 461,715, respectively (Dec 2019 –June 2020). Given the high mortality rate and economic damage to various communities to date, great efforts must be made to produce successful drugs and vaccines against 2019-nCoV infection. For this reason, first of all, the characteristics of the virus, its pathogenicity, and its infectious pathways must be well known. Thus, the main purpose of this review is to provide an overview of this epidemic disease based on the current evidence.
scTyper: a comprehensive pipeline for the cell typing analysis of single-cell RNA-seq data
Authors: Choi Ji-Hye , In Kim Hye , Woo Hyun Goo 
Published: August 2020

Abstract
Background
Recent advances in single-cell RNA sequencing (scRNA-seq) technology have enabled the identification of individual cell types, such as epithelial cells, immune cells, and fibroblasts, in tissue samples containing complex cell populations. Cell typing is one of the key challenges in scRNA-seq data analysis that is usually achieved by estimating the expression of cell marker genes. However, there is no standard practice for cell typing, often resulting in variable and inaccurate outcomes.

Results
We have developed a comprehensive and user-friendly R-based scRNA-seq analysis and cell typing package, scTyper. scTyper also provides a database of cell type markers, scTyper.db, which contains 213 cell marker sets collected from literature. These marker sets include but are not limited to markers for malignant cells, cancer-associated fibroblasts, and tumor-infiltrating T cells. Additionally, scTyper provides three customized methods for estimating cell-type marker expression, including nearest template prediction (NTP), gene set enrichment analysis (GSEA), and average expression values. DNA copy number inference method (inferCNV) has been implemented with an improved modification that can be used for malignant cell typing. The package also supports the data preprocessing pipelines by Cell Ranger from 10X Genomics and the Seurat package. A summary reporting system is also implemented, which may facilitate users to perform reproducible analyses.

Conclusions
scTyper provides a comprehensive and user-friendly analysis pipeline for cell typing of scRNA-seq data with a curated cell marker database, scTyper.db.
Spectrum of podocytopathies in new-onset nephrotic syndrome following COVID-19 disease: a report of 2 cases
Authors: Gupta Rajib K. , Bhargava Ramya , Shaukat Al-Aman , Albert Emily , Leggat John 
Published: August 2020

Abstract
Background
Coronavirus disease-2019 (COVID-19) is an ongoing pandemic which has affected over 12 million people across the globe. Manifestations in different organs systems are being reported regularly. Renal biopsy findings in hospitalized COVID-19 patients presenting solely with acute kidney injury (AKI) have recently been described in published literature in few case reports. The findings include diffuse acute tubular injury (ATI) along with the glomerular lesion of collapsing glomerulopathy (CG). However, nephrotic syndrome as the presenting complaint of COVID-19 has not been reported widely, neither has any other glomerular lesion other than CG.

Case presentation
We describe the kidney biopsy findings of two patients who had recent diagnoses of COVID-19 and presented with new-onset nephrotic syndrome. Renal biopsy in both patients showed ATI (as in previous reports) and distinct glomerular findings on light microscopy – that of minimal change disease (MCD) initially in one patient followed by CG in a subsequent biopsy and CG at the outset in the other patient. The electron microscopic findings in both patients were that of severe podocytopathy (diffuse and severe podocyte foot process effacement).

Conclusion
Our cases highlight a novel clinical presentation of COVID-19 renal disease, not described before, that of new-onset nephrotic syndrome. While all published case reports describe CG as the glomerular pathology, we describe a non-CG pathology (MCD) in one of our cases, thereby adding to the repertoire of renal pathology described in association with COVID-19 patients. However, the exact mechanism by which podocyte injury or podocytopathy occurs in all such cases is still unknown. Optimal treatment options for these patients also remains unknown at this time.