bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical outcomes in a large pediatric cohort of patients with ependymoma treated with proton radiotherapy
Authors: Patteson Brooke E , Baliga Sujith , Bajaj Benjamin V M , MacDonald Shannon M , Yeap Beow Y , Gallotto Sara L , Giblin Megan J , Weyman Elizabeth A , Ebb David H , Huang Mary S , Jones Robin M , Tarbell Nancy J , Yock Torunn I 
Published: June 2020

Abstract

Background
Treatment for pediatric ependymoma includes surgical resection followed by local radiotherapy (RT). Proton RT (PRT) enables superior sparing of critical structures compared with photons, with potential to reduce late effects. We report mature outcomes, patterns of failure, and predictors of outcomes in patients treated with PRT.

Methods
One hundred fifty patients (&lt;22 y) with World Health Organization grades II/III ependymoma were treated with PRT between January 2001 and January 2019 at Massachusetts General Hospital. Demographic, tumor, and treatment-related characteristics were analyzed. Event-free survival (EFS), overall survival (OS), and local control (LC) were assessed.

Results
Median follow-up was 6.5 years. EFS, OS, and LC for the intracranial cohort (n = 145) at 7 years were 63.4%, 82.6%, and 76.1%. Fifty-one patients recurred: 26 (51.0%) local failures, 19 (37.3%) distant failures, and 6 (11.8%) synchronous failures. One hundred sixteen patients (77.3%) underwent gross total resection (GTR), 5 (3.3%) underwent near total resection (NTR), and 29 (19.3%) underwent subtotal resection (STR). EFS for the intracranial cohort at 7 years for GTR/NTR and STR was 70.3% and 35.2%. With multivariate analysis, the effect of tumor excision persisted after controlling for tumor location. There was no adverse effect on disease control if surgery to RT interval was within 9 weeks of GTR/NTR.

Conclusion
PRT is effective and safe in pediatric ependymoma. Similar to previous studies, GTR/NTR was the most important prognostic factor. Intervals up to 9 weeks from surgery to PRT did not compromise disease outcomes. There was no LC benefit between patients treated with &gt;54 Gray relative biological effectiveness (GyRBE) versus ≤54 GyRBE.
Treatment and surgical factors associated with longer-term glioblastoma survival: a National Cancer Database study
Authors: Malay Sindhoosha , Somasundaram Eashwar , Patil Nirav , Buerki Robin , Sloan Andrew , Barnholtz-Sloan Jill S 
Published: June 2020

Abstract

Background
Insufficient data exist to characterize factors associated with longer-term survival of glioblastoma (GBM). A population-based analysis of GBM longer-term survivors (LTS) in the United States was conducted to investigate the association between treatment, demographic, surgical factors, and longer-term survival.

Methods
From the National Cancer Database, GBM patients were identified using ICD-O-3 histology codes 9440-9442/3, 2005–2015 and were divided into routine (≤3 years) and longer-term (&gt;3 years) overall survival (OS) groups. Univariable and multivariable logistic regression analysis was used to assess factors associated with longer-term survival. A subset analysis was performed to further investigate the association of extent of resection and treatment combinations on OS outcomes.

Results
A total of 93 036 patients with GBM met study criteria. Among these patients, 8484 were LTS and 84 552 were routine survivors (RS). When comparing LTS (OS of &gt;3 years) with RS (OS of ≤3 years), younger age, insured status, metro/urban residence, treatment at academic facility, and fewer comorbidities were associated with longer-term survival. In addition, trimodality therapy (chemotherapy + radiation + surgery) was associated with having best odds of longer-term survival (odds ratio = 4.89, 95% confidence interval [3.58, 6.68]); 74% of LTS received such therapy compared with 51% of RS. Subset analysis revealed that total resection is only associated with longer-term survival status for those receiving trimodality therapy or surgery only.

Conclusions
In a population-based analysis, standard of care surgery and chemo radiation connote a survival advantage in GBM. Among those receiving standard of care, having a total resection is most beneficial for longer-term survival status.
Nutritional perspectives for the prevention and mitigation of COVID-19
Authors: Akhtar Saeed , Das Jai K , Ismail Tariq , Wahid Muqeet , Saeed Wisha , Bhutta Zulfiqar A 
Published: June 2020

AbstractWorldwide, there is an array of clinical trials under way to evaluate treatment options against coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2. Concurrently, several nutritional therapies and alternative supportive treatments are also being used and tested to reduce the mortality associated with acute respiratory distress in patients with COVID-19. In the context of COVID-19, improved nutrition that includes micronutrient supplementation to augment the immune system has been recognized as a viable approach to both prevent and alleviate the severity of the infection. The potential role of micronutrients as immune-boosting agents is particularly relevant for low- and middle-income countries, which already have an existing high burden of undernutrition and micronutrient deficiencies. A systematic literature review was performed to identify nutritional interventions that might prevent or aid in the recovery from COVID-19. The PubMed, ScienceDirect, Cochrane, Scopus, Web of Science, and Google Scholar databases were searched electronically from February to April 2020. All abstracts and full-text articles were examined for their relevance to this review. The information gathered was collated under various categories. Deficiencies of micronutrients, especially vitamins A, B complex, C, and D, zinc, iron, and selenium, are common among vulnerable populations in general and among COVID-19 patients in particular and could plausibly increase the risk of mortality. Judicious use of need-based micronutrient supplementation, alongside existing micronutrient fortification programs, is warranted in the current global pandemic, especially in low- and middle-income economies.
Brain iron concentrations in the pathophysiology of children with attention deficit/hyperactivity disorder: a systematic review
Authors: Degremont Alexia , Jain Rishika , Philippou Elena , Latunde-Dada Gladys Oluyemisi 
Published: June 2020

Abstract

Context
Attention deficit/hyperactivity disorder (ADHD) is a neurological disorder associated with iron dysregulation in children. Although previous focus was on examining systemic iron status, brain iron content may be a more reliable biomarker of the disorder.

Objective
This systematic review examines whether children with ADHD have lower serum as well as brain iron concentrations, compared with healthy control subjects (HCS).

Data sources
A systematic literature search was conducted in Medline via PubMed, the Cochrane Library, Web of Science, Embase. and Ovid for papers published between 2000 and June 7, 2019.

Data extraction
Studies were included if the mean difference of iron concentration, measured as serum iron, serum ferritin, or brain iron, between children with ADHD and HCS was an outcome measure.

Data analysis
Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. Risks of bias within and between studies were assessed using the quality assessment tools of the National Institutes of Health. Of 599 records screened, 20 case-control studies met the inclusion criteria. In 10 of 18 studies in which serum ferritin concentration was assessed, and 2 of 10 studies that assessed serum iron, a significant difference between children with ADHD and HCS was observed. Results of systemic iron levels were inconsistent. In 3 studies in which brain iron concentration was assessed, a statistically significant, lower thalamic iron concentration was found in children with ADHD than in HCS.

Conclusion
The evidence, though limited, reveals that brain iron rather than systemic iron levels may be more associated with the pathophysiology of ADHD in children. Larger, longitudinal, magnetic resonance imaging studies are needed to examine any correlations of iron deficiency in specific brain regions and symptoms of ADHD.
A New Frame? Transforming Policing through Guarantees of Non-Repetition
Authors: McGonigle Leyh Brianne 
Published: June 2020

AbstractUsing qualitative legal scholarship, combined with literature analysis from post-conflict peacebuilding and police studies, this article provides a normative and theoretical lens through which police and other actors can view and carry out reform efforts. It explores whether and how the concept of guarantees of non-repetition could contribute to or reframe discussions in order to prevent future violence and facilitate lasting institutional changes. The article examines the development of a broader approach to security sector reform and explores guarantees of non-repetition and the conceptual confusion it has encountered. It teases out the main aspects of guarantees of non-repetition, including its human rights elements, such as due diligence obligations. Finally, it addresses how guarantees of non-repetition provide a normative institutional policy framework that offers the possibility to shift the rhetoric to focus on State obligations that are context-driven. As a result, guarantees of non-repetition could prove useful when addressing police reform.
Changes in Police Calls for Service During the Early Months of the 2020 Coronavirus Pandemic
Authors: Ashby Matthew P J 
Published: June 2020

Abstract
The coronavirus pandemic poses multiple challenges for policing, including the need to continue responding to calls from the public. Several contingency plans warned police to expect a large and potentially overwhelming increase in demand from the public during a pandemic, but (to the author’s knowledge) there is no empirical work on police demand during a major public health emergency. This study used calls-for-service data from 10 large cities in the USA to analyse how calls for service changed during the early months of the 2020 COVID-19 outbreak, compared to forecasts of call volume based on data from previous years. Contrary to previous warnings, overall the number of calls went down during the early weeks of the pandemic. There were substantial reductions in specific call types, such as traffic collisions, and significant increases in others, such as calls to dead bodies. Other types of calls, particularly those relating to crime and order maintenance, continued largely as before. Changes in the frequency of different call types present challenges to law enforcement agencies, particularly since many will themselves be suffering from reduced staffing due to the pandemic. Understanding changes to calls in detail will allow police leaders to put in place evidence-based plans to ensure they can continue to serve the public.
How Robust Is Evidence of Partisan Perceptual Bias in Survey Responses?
Authors: Yair Omer , Huber Gregory A. 
Published: June 2020

Abstract
Partisans often offer divergent responses to survey items ostensibly unrelated to politics. These gaps could reveal that partisanship colors perception or, alternatively, that in answering survey questions, individuals communicate partisan proclivities by providing insincere, or “expressive” responses, to send a partisan message. This study tests two techniques for reducing expressive responding that (1) avoid criticisms about using monetary incentives for accuracy, which have reduced measured partisan differences for objective facts; and (2) can be used in contexts where incentives are infeasible, such as when objective benchmarks for correct responses are unavailable. This study experimentally tests these techniques in replicating a study that found that partisanship affected attractiveness evaluations. These interventions, which allow partisans to express their partisan sentiments through other survey items, substantially reduce apparent partisan differences in beauty evaluations and show that standard survey items likely confound sincere partisan differences with elements of expressive responding.
Rethinking the Use of Credit Ratings in Capital Regulations: Evidence From the Insurance Industry
Authors: Hanley Kathleen Weiss , Nikolova Stanislava 
Published: June 2020

Abstract
We analyze an initiative by insurance regulators to reform capital regulations for mortgage-backed securities (MBS) by replacing credit ratings with third-party estimates of expected credit losses and by considering an insurer’s exposure to future losses when determining regulatory capital. After implementation, insurers are less likely to sell distressed MBS, gains trade corporate bonds, and/or raise external financing. However, the new regime allows insurers to purchase more low-rated MBS at significant capital savings and insurers with greater capital savings are more likely to do so. Our analysis highlights the potential costs and benefits of an alternative methodology for determining regulatory capital. JEL (G11, G18, G22, G28, G32, G38).
Received May 6, 2019; editorial decision April 4, 2020 by Editor Andrew Ellul.
Cognitive dysfunction and serum levels of brain-derived neurotrophic factor (BDNF) in primary anti-phospholipid syndrome (PAPS)
Authors: Rosa Renata F , Ugolini-Lopes Michelle Remião , Gandara Ana Paula Rossi , Vendramini Margarete B G , Campanholo Kenia Repiso , Dutra Livia , de Andrade Danieli Castro Oliveira 
Published: June 2020

Abstract

Objectives
Cognitive dysfunction (CD) is a poorly understood non-stroke central neurological manifestation in anti-phospholipid syndrome (APS). Brain-derived neurotrophic factor (BDNF) is a neurotrophin that plays an important role in neural plasticity and could potentially be a biomarker of CD in primary APS (PAPS). The aim of the study is to assess CD in PAPS patients and to evaluate its association with clinical data, anti-phospholipid antibodies and serum BDNF levels.

Methods
This cross-sectional study compared 44 PAPS patients and 20 healthy controls matched for age, gender and education. PAPS patients and controls underwent a standardized cognitive examination. The demographic, clinical and laboratory characteristics of patients were recorded. Serum BDNF was measured by Enzyme Linked Immunosorbent.

Results
Fourteen (31.8%) of the 44 patients with PAPS had CD compared with only one (5%) healthy control (P =0.019). PAPS patients presented lower serum BDNF levels when compared with controls (P =0.007). Lower levels of BDNF were associated with CD in PAPS patients (P =0.032). In the univariate analysis, a positive association was found between CD and livedo reticularis, deep vein thrombosis, stroke, seizure, smoking as well as a negative association with Mini Mental State Examination and serum BDNF. According to multivariate analysis, the only independent predictor of CD in PAPS was stroke (OR 137.06; 95% CI: 4.73, 3974.32; P =0.004).

Conclusions
CD is commonly reported in PAPS patients; however, its assessment lacks in standards and objective screening tests. The association between CD and low serum BDNF suggests that this neurotrophin can be a promising biomarker for PAPS cognitive impairment.
DOSE ASSESSMENT FOR ATMOSPHERIC DISCHARGE OF LONG-LIVED RADIONUCLIDES IN NUCLEAR POWER PLANT DECOMMISSIONING
Authors: S Chitra , Anand S , Bhargava Pradeep , Krishan Jayant , Singh Kapil Deo S , Kulkarni M S , Sharma D N 
Published: June 2020

AbstractDecommissioning of nuclear power plants is a multistage process involving complex operations like radiological characterization, decontamination and dismantling of plant equipment, demolition of structures, and processing and disposal of waste. Radioactive effluents released into the environment may result in exposure of population through various exposure pathways. The present study estimates the public dose due to atmospheric discharge of important radionuclides during proposed decommissioning activities of Indian Pressurized Heavy Water Reactors. This study shows that major dose contributing radionuclides are 60Co followed by 94Nb, 134Cs, 154Eu, 152Eu, 133Ba, 99Tc, 93Mo and 41Ca. It is found that infant dose is higher than adult dose and major fraction of total dose (~98%) is through ground shine and ingestion; other pathways such as inhalation and plume shine contribute only a small fraction. This study will be helpful in carrying out radiological impact assessment for decommissioning operations which is an important regulatory requirement.
Neural Correlates of True and False Recognition Memory for Socially Relevant Information in Schizophrenia
Authors: Jimenez Amy M , Lee Junghee , Reavis Eric A , Wynn Jonathan K , Green Michael F 
Published: June 2020

Abstract
Individuals with schizophrenia (SZ) demonstrate poor recognition memory, even when information is socially relevant. The neural alterations associated with responses to old information that is accurately recognized (true recognition) vs new information inaccurately identified as old (false recognition) are not known. Twenty SZ patients and 16 healthy controls performed a recognition paradigm during functional magnetic resonance imaging (fMRI) using 78 learned target and 78 new distractor words (all socially relevant trait adjectives). Participants were asked to indicate whether they had seen the word before or not. Words were classified according to the subjects’ responses, as hits (true recognition), false alarms (false recognition), correct rejections, or misses and compared for blood-oxygen-level-dependent (BOLD) activation. During hits, patients with SZ and controls showed similar BOLD activation in expected areas of lateral prefrontal cortex, parietal cortex, and anterior cingulate cortex. During false alarms, controls activated many of the same regions as were activated during hits. In contrast, patients had reduced activation in lateral prefrontal cortex (Brodmann Area, BA, 9, 46), anterior cingulate/paracingulate (BA 24/32, 6), and posterior cingulate cortex (BA 23/31). These results indicate that, compared to controls, patients with SZ exhibit a lack of correspondence between behavior (ie, falsely identifying new items as old) and neural activation patterns (ie, overlap in activation of regions associated with true and false recognition). These findings shed light on the neural mechanisms associated with false recognition memory in SZ.
Interventions to reduce short-wavelength (“blue”) light exposure at night and their effects on sleep: A systematic review and meta-analysis
Authors: Shechter Ari , Quispe Kristal A , Mizhquiri Barbecho Jennifer S , Slater Cody , Falzon Louise 
Published: June 2020

AbstractThe sleep-wake and circadian cycles are influenced by light, particularly in the short-wavelength portion of the visible spectrum. Most personal light-emitting electronic devices are enriched in this so-called “blue” light. Exposure to these devices in the evening can disturb sleep. Interventions to reduce short-wavelength light exposure before bedtime may reduce adverse effects on sleep. We conducted a systematic review and meta-analysis to examine the effect of wearing color-tinted lenses (e.g. orange or amber) in frames to filter short-wavelength light exposure to the eye before nocturnal sleep. Outcomes were self-reported or objective measures of nocturnal sleep. Relatively few (k = 12) studies have been done. Study findings were inconsistent, with some showing benefit and others showing no effect of intervention. Meta-analyses yielded a small-to-medium magnitude combined effect size for sleep efficiency (Hedge’s g = 0.31; 95% CI: −0.05, 0.66; I2 = 38.16%; k = 7), and a small-to-medium combined effect size for total sleep time (Hedge’s g = 0.32; 95% CI: 0.01, 0.63; I2 = 12.07%; k = 6). For self-report measures, meta-analysis yielded a large magnitude combined effects size for Pittsburgh Sleep Quality Index ratings (Hedge’s g = −1.25; 95% CI: −2.39, −0.11; I2 = 36.35%; k = 3) and a medium combined effect size for total sleep time (Hedge’s g = 0.51; 95% CI: 0.18, 0.84; I2 = 0%; k = 3), Overall, there is some, albeit mixed, evidence that this approach can improve sleep, particularly in individuals with insomnia, bipolar disorder, delayed sleep phase syndrome, or attention-deficit hyperactive disorder. Considering the ubiquitousness of short-wavelength-enriched light sources, future controlled studies to examine the efficacy of this approach to improve sleep are warranted.Systematic review registration: PROSPERO 2018 CRD42018105854.
Factors Associated With Family Medicine and Internal Medicine First-Year Residents’ Ambulatory Care Training Time
Authors: Kim Jung G. , Rodriguez Hector P. , Shortell Stephen M. , Fuller Bruce , Holmboe Eric S. , Rittenhouse Diane R. 
Published: June 2020

Purpose
Despite the importance of training in ambulatory care settings for residents to acquire important competencies, little is known about the organizational and environmental factors influencing the relative amount of time primary care residents train in ambulatory care during residency. The authors examined factors associated with postgraduate year 1 (PGY-1) residents’ ambulatory care training time in Accreditation Council for Graduate Medical Education (ACGME)-accredited primary care programs.

Method
U.S.-accredited family medicine (FM) and internal medicine (IM) programs’ 2016–2017 National Graduate Medical Education (GME) Census data from 895 programs within 550 sponsoring institutions (representing 13,077 PGY-1s) were linked to the 2016 Centers for Medicare and Medicaid Services Cost Reports and 2015–2016 Area Health Resource File. Multilevel regression models examined the association of GME program characteristics, sponsoring institution characteristics, geography, and environmental factors with PGY-1 residents’ percentage of time spent in ambulatory care.

Results
PGY-1 mean (standard deviation, SD) percent time spent in ambulatory care was 25.4% (SD, 0.4) for both FM and IM programs. In adjusted analyses (% increase [standard error, SE]), larger faculty size (0.03% [SE, 0.01], P < .001), sponsoring institution’s receipt of Teaching Health Center (THC) funding (6.6% (SE, 2.7), P < .01), and accreditation warnings (4.8% [SE, 2.5], P < .05) were associated with a greater proportion of PGY-1 time spent in ambulatory care. Programs caring for higher proportions of Medicare beneficiaries spent relatively less time in ambulatory care (< 0.5% [SE, 0.2], P < .01).

Conclusions
Ambulatory care time for PGY-1s varies among ACGME-accredited primary care residency programs due to the complex context and factors primary care GME programs operate under. Larger ACGME-accredited FM and IM programs and those receiving federal THC GME funding had relatively more PGY-1 time spent in ambulatory care settings. These findings inform policies to increase resident exposure in ambulatory care, potentially improving learning, competency achievement, and primary care access.