bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mild maternal sleep-disordered breathing during pregnancy and offspring growth and adiposity in the first 3 years of life
Authors: Brener Avivit , Lebenthal Yael , Levy Sigal , Dunietz Galit Levi , Sever Orna , Tauman Riva 
Published: August 2020

AbstractSleep-disordered breathing (SDB) during pregnancy has been linked to adverse fetal outcomes. Since the intrauterine milieu plays a critical role in childhood growth, we explored the interactions between maternal SDB and offspring growth and adiposity patterns during infancy. Fifty-eight healthy women with uncomplicated pregnancies underwent an objective sleep study and laboratory evaluation during the third trimester, their offspring underwent a 3-year growth surveillance. The 14 (24.1%) women with SDB had a higher body mass index (BMI) (P = 0.003), elevated C-reactive protein levels (P = 0.003), and decreased HDL-cholesterol levels (P = 0.009) than the women without SDB. A general linear model evaluated the interactions between maternal SDB and offspring growth and adiposity measurements after controlling for gestational age and maternal and paternal BMIs. The offspring of mothers with SDB had a significantly smaller head circumference at birth (P = 0.004), with a distinctive pattern of catchup growth by the end of the first year of life (P = 0.018). Their growth pattern was distinguished by compromised birth weight-to-length, rapid catch-up growth, and an increase in both weight-to-length and triceps thickness by the age of three (P < 0.001 and P = 0.001, respectively). Our findings suggest that maternal SDB during pregnancy affects head circumference growth and adiposity acquisition from birth through infancy.
Speech-in-noise detection is related to auditory working memory precision for frequency
Authors: Lad Meher , Holmes Emma , Chu Agatha , Griffiths Timothy D. 
Published: August 2020

AbstractSpeech-in-noise (SiN) perception is a critical aspect of natural listening, deficits in which are a major contributor to the hearing handicap in cochlear hearing loss. Studies suggest that SiN perception correlates with cognitive skills, particularly phonological working memory: the ability to hold and manipulate phonemes or words in mind. We consider here the idea that SiN perception is linked to a more general ability to hold sound objects in mind, auditory working memory, irrespective of whether the objects are speech sounds. This process might help combine foreground elements, like speech, over seconds to aid their separation from the background of an auditory scene. We investigated the relationship between auditory working memory precision and SiN thresholds in listeners with normal hearing. We used a novel paradigm that tests auditory working memory for non-speech sounds that vary in frequency and amplitude modulation (AM) rate. The paradigm yields measures of precision in frequency and AM domains, based on the distribution of participants’ estimates of the target. Across participants, frequency precision correlated significantly with SiN thresholds. Frequency precision also correlated with the number of years of musical training. Measures of phonological working memory did not correlate with SiN detection ability. Our results demonstrate a specific relationship between working memory for frequency and SiN. We suggest that working memory for frequency facilitates the identification and tracking of foreground objects like speech during natural listening. Working memory performance for frequency also correlated with years of musical instrument experience suggesting that the former is potentially modifiable.
Correlated clusters of closed reaction centers during induction of intact cells of photosynthetic bacteria
Authors: Maróti Péter , Kovács István A. , Kis Mariann , Smart James L. , Iglói Ferenc 
Published: August 2020

AbstractAntenna systems serve to absorb light and to transmit excitation energy to the reaction center (RC) in photosynthetic organisms. As the emitted (bacterio)chlorophyll fluorescence competes with the photochemical utilization of the excitation, the measured fluorescence yield is informed by the migration of the excitation in the antenna. In this work, the fluorescence yield concomitant with the oxidized dimer (P+) of the RC were measured during light excitation (induction) and relaxation (in the dark) for whole cells of photosynthetic bacterium Rhodobacter sphaeroides lacking cytochrome c2 as natural electron donor to P+ (mutant cycA). The relationship between the fluorescence yield and P+ (fraction of closed RC) showed deviations from the standard Joliot–Lavergne–Trissl model: (1) the hyperbola is not symmetric and (2) exhibits hysteresis. These phenomena originate from the difference between the delays of fluorescence relative to P+ kinetics during induction and relaxation, and in structural terms from the non-random distribution of the closed RCs during induction. The experimental findings are supported by Monte Carlo simulations and by results from statistical physics based on random walk approximations of the excitation in the antenna. The applied mathematical treatment demonstrates the generalization of the standard theory and sets the stage for a more adequate description of the long-debated kinetics of fluorescence and of the delicate control and balance between efficient light harvest and photoprotection in photosynthetic organisms.
Sublingual indocyanine green films for non-invasive swallowing assessment and inflammation detection through NIR/SWIR optical imaging
Authors: Beringhs André O’Reilly , Singh Surya Pratap , Valdez Tulio Alberto , Lu Xiuling 
Published: August 2020

AbstractIndocyanine green (ICG) is the most commonly used FDA-approved agent for clinical optical imaging, administered through injections only, due to its poor membrane permeability. Although ICG has vast potential for non-invasive non-radioactive imaging in patients, the clinical applications are limited by the invasive administration and short half-life in blood circulation. To expand the clinical value of ICG, non-toxic chitosan-based ICG-loaded films were designed for sublingual administration for near-infrared (NIR) and short-wave infrared (SWIR) optical imaging. Two film formulations were developed with different ICG release rates. Mold-casted self-emulsifying films rapidly released ICG (80% in 4 h) in the form of nanosized droplets, which were mostly swallowed and produced significant contrast of upper digestive tract to enable in vivo swallowing evaluations using NIR/SWIR imaging. Regular films released ICG slowly (80% in 25 h), allowing for steady absorption of ICG to systemic circulation. Inflammation in mouse feet was detected within 30 min after sublingual administration with a 1.43-fold fluorescence increase within 1 h at the inflammation sites, comparable to a 1.76-fold increase through intravenous injection. Administering ICG using sublingual films displayed notable potential for non-invasive diagnosis and monitoring of inflammatory conditions and swallowing disorders, addressing a current need for alternatives to ICG parenteral administration.
International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium
Authors: Brat Gabriel A. , Weber Griffin M. , Gehlenborg Nils , Avillach Paul , Palmer Nathan P. , Chiovato Luca , Cimino James , Waitman Lemuel R. , Omenn Gilbert S. , Malovini Alberto , Moore Jason H. , Beaulieu-Jones Brett K. , Tibollo Valentina , Murphy Shawn N. , Yi Sehi L’ , Keller Mark S. , Bellazzi Riccardo , Hanauer David A. , Serret-Larmande Arnaud , Gutierrez-Sacristan Alba , Holmes John J. , Bell Douglas S. , Mandl Kenneth D. , Follett Robert W. , Klann Jeffrey G. , Murad Douglas A. , Scudeller Luigia , Bucalo Mauro , Kirchoff Katie , Craig Jean , Obeid Jihad , Jouhet Vianney , Griffier Romain , Cossin Sebastien , Moal Bertrand , Patel Lav P. , Bellasi Antonio , Prokosch Hans U. , Kraska Detlef , Sliz Piotr , Tan Amelia L. M. , Ngiam Kee Yuan , Zambelli Alberto , Mowery Danielle L. , Schiver Emily , Devkota Batsal , Bradford Robert L. , Daniar Mohamad , Daniel Christel , Benoit Vincent , Bey Romain , Paris Nicolas , Serre Patricia , Orlova Nina , Dubiel Julien , Hilka Martin , Jannot Anne Sophie , Breant Stephane , Leblanc Judith , Griffon Nicolas , Burgun Anita , Bernaux Melodie , Sandrin Arnaud , Salamanca Elisa , Cormont Sylvie , Ganslandt Thomas , Gradinger Tobias , Champ Julien , Boeker Martin , Martel Patricia , Esteve Loic , Gramfort Alexandre , Grisel Olivier , Leprovost Damien , Moreau Thomas , Varoquaux Gael , Vie Jill-Jênn , Wassermann Demian , Mensch Arthur , Caucheteux Charlotte , Haverkamp Christian , Lemaitre Guillaume , Bosari Silvano , Krantz Ian D. , South Andrew , Cai Tianxi , Kohane Isaac S. 
Published: August 2020

AbstractWe leveraged the largely untapped resource of electronic health record data to address critical clinical and epidemiological questions about Coronavirus Disease 2019 (COVID-19). To do this, we formed an international consortium (4CE) of 96 hospitals across five countries (www.covidclinical.net). Contributors utilized the Informatics for Integrating Biology and the Bedside (i2b2) or Observational Medical Outcomes Partnership (OMOP) platforms to map to a common data model. The group focused on temporal changes in key laboratory test values. Harmonized data were analyzed locally and converted to a shared aggregate form for rapid analysis and visualization of regional differences and global commonalities. Data covered 27,584 COVID-19 cases with 187,802 laboratory tests. Case counts and laboratory trajectories were concordant with existing literature. Laboratory tests at the time of diagnosis showed hospital-level differences equivalent to country-level variation across the consortium partners. Despite the limitations of decentralized data generation, we established a framework to capture the trajectory of COVID-19 disease in patients and their response to interventions.
Structural studies reveal flexible roof of active site responsible for ω-transaminase CrmG overcoming by-product inhibition
Authors: Xu Jinxin , Tang Xiaowen , Zhu Yiguang , Yu Zhijun , Su Kai , Zhang Yulong , Dong Yan , Zhu Weiming , Zhang Changsheng , Wu Ruibo , Liu Jinsong 
Published: August 2020

AbstractAmine compounds biosynthesis using ω-transaminases has received considerable attention in the pharmaceutical industry. However, the application of ω-transaminases was hampered by the fundamental challenge of severe by-product inhibition. Here, we report that ω-transaminase CrmG from Actinoalloteichus cyanogriseus WH1-2216-6 is insensitive to inhibition from by-product α-ketoglutarate or pyruvate. Combined with structural and QM/MM studies, we establish the detailed catalytic mechanism for CrmG. Our structural and biochemical studies reveal that the roof of the active site in PMP-bound CrmG is flexible, which will facilitate the PMP or by-product to dissociate from PMP-bound CrmG. Our results also show that amino acceptor caerulomycin M (CRM M), but not α-ketoglutarate or pyruvate, can form strong interactions with the roof of the active site in PMP-bound CrmG. Based on our results, we propose that the flexible roof of the active site in PMP-bound CrmG may facilitate CrmG to overcome inhibition from the by-product.
Exploiting two-dimensional hybrid perovskites incorporating secondary amines for high-performance array photodetection
Authors: Yang Tao , Li Yaobin , Han Shiguo , Liu Yi , Xu Zhiyun , Li Maofan , Wang Jiaqi , Ma Yu , Luo Junhua , Sun Zhihua 
Published: August 2020

We present a new 2D hybrid perovskite by alloying secondary dimethylammonium cation as the “perovskiter” into the PbI3 framework, which shows the strong in-plane photoresponses.
Millimeter- and submillimeter-wave spectroscopy of thioformamide and interstellar search toward Sgr B2(N)
Authors: Motiyenko R. A. , Belloche A. , Garrod R. T. , Margulès L. , Müller H. S. P. , Menten K. M. , Guillemin J.-C. 
Published: August 2020

Context.Thioformamide NH2CHS is a sulfur-bearing analog of formamide NH2CHO. The latter was detected in the interstellar medium back in the 1970s. Most of the sulfur-containing molecules detected in the interstellar medium are analogs of corresponding oxygen-containing compounds. Therefore, thioformamide is an interesting candidate for a search in the interstellar medium.Aims.A previous study of the rotational spectrum of thioformamide was limited to frequencies below 70 GHz and to transitions withJ ≤ 3. The aim of this study is to provide accurate spectroscopic parameters and rotational transition frequencies for thioformamide to enable astronomical searches for this molecule using radio telescope arrays at millimeter wavelengths.Methods.The rotational spectrum of thioformamide was measured and analyzed in the frequency range 150−660 GHz using the Lille spectrometer. We searched for thioformamide toward the high-mass star-forming region Sagittarius (Sgr) B2(N) using the ReMoCA spectral line survey carried out with the Atacama Large Millimeter/submillimeter Array.Results.Accurate rigid rotor and centrifugal distortion constants were obtained from the analysis of the ground state of parent,34S,13C, and15N singly substituted isotopic species of thioformamide. In addition, for the parent isotopolog, the lowest two excited vibrational states,v12 = 1 andv9 = 1, were analyzed using a model that takes Coriolis coupling into account. Thioformamide was not detected toward the hot cores Sgr B2(N1S) and Sgr B2(N2). The sensitive upper limits indicate that thioformamide is nearly three orders of magnitude at least less abundant than formamide. This is markedly different from methanethiol, which is only about two orders of magnitude less abundant than methanol in both sources.Conclusions.The different behavior shown by methanethiol versus thioformamide may be caused by the preferential formation of the latter (on grains) at late times and low temperatures, when CS abundances are depressed. This reduces the thioformamide-to-formamide ratio, because the HCS radical is not as readily available under these conditions.
Formation of Communicative Abilities of Children in The Conditions of Pedagogical Design
Authors: Kuchkareva Svetlana Sergeevna 
Published: August 2020

The purpose of this study is to identify communication problems and determine optimal conditions for further reproduction of experience in pedagogical practice for effective communication formation in children.
Analysis of the literature has revealed several causes of communication problems. The genetic predisposition affects the interaction with others, but by creating a favorable environment for children, it is possible to adjust the regulation of behavior by pedagogical influences and form the child’s communicative skills that will help them to stay and interact with people around them without harm to themself and society. The emotional internal state can also negatively affect the relationship with others and, if one teaches the child to relieve internal stress, negative situations can be avoided. Also, if one teaches a child to recognize the emotional state from others, then it will also help to avoid many problems in communication and interaction with others. The article describes the principles and conditions of effective formation of communicative skills in children, defines criteria, as well as the definition, of pedagogical design of communication of children. Pedagogical design is a condition for the successful formation of the communicative skills of the child. In this regard, the teacher needs to provide a favorable communicative space of the child. The article is oriented to use in practical activities and can be useful to methodologists and employees of educational institutions.
Fallbericht einer Frontobasisrekonstruktion und Volumenkorrektur durch freie M. gracilis-Lappenplastik und autologe Fett-Transplantation – Die Lappenplastik als Scaffold für eine Fettgewebe-Transplantation
Authors: Möllhoff Nicholas , Koban Konstantin Christoph , Engelhardt Timm Oliver , Tonn Joerg Christian , Giunta Riccardo E. 
Published: August 2020

ZusammenfassungDieser Fallbericht zeigt die interdisziplinäre Behandlung einer 28-jährigen Patientin mit ausgeprägtem frontalen Volumendefekt nach schwerem Schädelhirntrauma. Durch die Kombination aus Schädeldachplastik mittels Polymethylmethacrylat (PMMA), freier M. gracilis-Lappenplastik und serieller Eigenfett-Transplantation in das transplantierte Muskelgewebe, konnte der Weichteildefekt ausgeglichen und eine ästhetische Rekonstruktion erzielt werden. Dieses Beispiel unterstreicht die Erweiterung des Behandlungsspektrums an interdisziplinären Exzellenzzentren durch Plastische Chirurgen, wodurch die Versorgung immer komplexerer Knochen-Weichteilläsionen möglich wird.
Beeinflussung des Ergebnisses eines semiquantitativen Schnelltests zur Ermittlung der Immunglobulin-G-Konzentration im Serum boviner Kälber
Authors: Hampe Marian , Failing Klaus , Söllner-Donat Stefanie , Wehrend Axel 
Published: August 2020

Zusammenfassung
Gegenstand und Ziel Der Fassisi® Bovine IgG Test ist ein Schnelltest zur Überprüfung der IgG-Versorgung im Blut von Kälbern. Untersucht werden sollte der subjektive Einfluss des Ablesers und des Zeitraums zwischen Durchführung und Auswertung des Tests auf das Ergebnis.
Material und Methode Der Schnelltest wurde an jeweils einer Serumprobe von 36 Kälbern im Alter von bis zu 10 Tagen durchgeführt. Die Auswertung erfolgte bei 12 Proben durch 6 Tierärzte/innen unabhängig voneinander. Bei 24 Proben wurde das Ergebnis durch eine Person nach 10 Minuten (Herstellerangabe) sowie nach 20 und 30 Minuten abgelesen.
Ergebnisse Bei 4 von 12 Proben (33,3 %) differierte das Ableseresultat verschiedener Untersucher und bei 5 von 24 Proben (20,8 %) fiel das Testergebnis bei längerem Zeitraum bis zur Ablesung höher oder niedriger aus. Die Diskrepanz betrug jeweils maximal eine Stufe und die Unterschiede waren statistisch nicht signifikant.
Klinische Relevanz Die Ablesung des Tests unterliegt subjektiven Schwankungen. Auf die vom Hersteller angegebene Zeit bis zur Ablesung ist genau zu achten. Die Ergebnisse der Untersuchung sollten anhand einer größeren Probenzahl verifiziert werden.
From Patient Engagement to Precision Oncology: Leveraging Informatics to Advance Cancer Care
Authors: Griffin Ashley C. , Topaloglu Umit , Davis Sean , Chung Arlene E. 
Published: August 2020

Objectives: Conduct a survey of the literature for advancements in cancer informatics over the last three years in three specific areas where there has been unprecedented growth: 1) digital health; 2) machine learning; and 3) precision oncology. We also highlight the ethical implications and future opportunities within each area.Methods: A search was conducted over a three-year period in two electronic databases (PubMed, Google Scholar) to identify peer-reviewed articles and conference proceedings. Search terms included variations of the following: neoplasms[MeSH], informatics[MeSH], cancer, oncology, clinical cancer informatics, medical cancer informatics. The search returned too many articles for practical review (23,994 from PubMed and 23,100 from Google Scholar). Thus, we conducted searches of key PubMed-indexed informatics journals and proceedings. We further limited our search to manuscripts that demonstrated a clear focus on clinical or translational cancer informatics. Manuscripts were then selected based on their methodological rigor, scientific impact, innovation, and contribution towards cancer informatics as a field or on their impact on cancer care and research.Results: Key developments and opportunities in cancer informatics research in the areas of digital health, machine learning, and precision oncology were summarized.Conclusion: While there are numerous innovations in the field of cancer informatics to advance prevention and clinical care, considerable challenges remain related to data sharing and privacy, digital accessibility, and algorithm biases and interpretation. The implementation and application of these findings in cancer care necessitates further consideration and research.
International Academy of Health Sciences Informatics (IAHSI): Strategy and Focus Areas, 1st Version
Authors: Martin-Sanchez Fernando , Ball Marion J. , Kimura Michio , Otero Paula , Huesing Elaine , Lehmann Christoph U. , Haux Reinhold 
Published: August 2020

Background: The International Academy of Health Sciences Informatics (IAHSI) is the Academy of the International Medical Informatics Association (IMIA). As an international forum for peers in biomedical and health informatics, the Academy shall play an important role in exchanging knowledge, providing education and training, and producing policy documents.
Objectives: A major priority of the Academy’s activities in its inaugural phase was to define its strategy and focus areas in accordance with its objectives and to prioritize the Academy’s work, which can then be transferred to respective taskforces.
Method: This document reflects the major outcomes of intensive discussions that occurred during 2019. It was presented at the Academy’s 3rd Plenary on August 25th, 2019, in Lyon, France.
Results: Regardless of the ‘living nature’ of the strategy and focus areas document, it was concluded during the Plenary that the first version, which will be used as a base for decisions on the Academy’s future activities, should be made available to a broad audience. Three out of eight ‘Visions for IAHSI‘, presented in the IMIA Yearbook of Medical Informatics 2018, were identified as central for developing, implementing, and evaluating the Academy’s strategic directions: (1) advise governments and organizations on developing health and health sciences through informatics, (2) stimulate progress in biomedical and health informatics research, education, and practice, and (3) share and exchange knowledge. Taskforces shall be implemented to work in the following areas, which were considered as priority themes: (1) artificial intelligence in health: future collaboration of entities with natural and with artificial intelligence in health care, and (2) current landscape of standards for digital health.
Conclusions: Taskforces are now being established. Besides specific key performance indicators, suggested for monitoring the work of theses taskforces, the strategy to monitor the progress of the Academy itself has to be measured by relevant and acceptable metrics.
Syntheses and Applications of Singh’s Catalyst
Authors: Khangarot Rama Kanwar , Khandelwal Manisha , Ray Sumit Kumar 
Published: August 2020

Singh’s catalyst has emerged as one of the most promising and valuable catalysts in the field of asymmetric synthesis. Since its discovery, it has proven to be one of the best organocatalysts for asymmetric direct aldol reactions, and is equally efficient in aqueous and organic media. In this Short Review, we summarize reactions utilizing Singh’s catalyst under various conditions.1	Introduction2	Synthesis of Singh’s Catalyst3	Applications in Asymmetric Synthesis4	Conclusion