bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Herbicidal Activities of Novel Substituted Acetophenone Oxime Esters of Pyrithiobac
Authors: Xu Xiangjian , Cai Xinhong , Wang Bin , Min Wei , Wang Qin , Lai Chao , Hu Hang , Xu Defeng 
Published: January 2020

AbstractA series of substituted acetophenone oxime esters of Pyrithiobac were synthesized as potential herbicides. The structures of the synthesized new compounds were confirmed by 1H NMR, 13C NMR, HRMS, and X‐ray single‐crystal diffraction (XRD). The pre‐emergence and post‐emergence herbicidal activity studies show that 4‐CF3 (6 f), 4‐NO2 (6 i), 4‐NH2 (6 j), 4‐F (6 l), and 2,4‐2OCH3 (6 s) substituted acetophenone oxime esters of Pyrithiobac exhibit better pre‐emergence and post‐emergence herbicidal activities against monocotyledon and dicotyledon weeds than other synthesized new compounds. In pre‐emergence herbicidal activity study, 6 f, 6 i, 6 j, 6 l, and 6 s exhibit similar herbicidal activities against monocotyledon and dicotyledon weeds as compared to Staple (Pyrithiobac‐sodium). In post‐emergence herbicidal activity study, 6 f, 6 i, 6 j, 6 l, and 6 s exhibit similar herbicidal activities against dicotyledon weeds and better herbicidal activities against monocotyledon weeds as compared to Staple. Compounds 6 i and 6 l with high herbicidal activities and similar binding mode with acetolactate synthase as compared to Staple were further subjected to crop safety study. The results show that the safety of compound 6 l to cotton is as good as Staple and better than 6 i. The present work indicates that compound 6 l may serve as a new candidate for potential herbicides.
Cu2MoS4 Nanotubes as a Cathode Material for Rechargeable Magnesium‐ion Battery
Authors: Le Ly T. , Truong Duc Q. , Ung Thuy T. D. , Nguyen Long H. , Vu Loi D. , Tran Phong D. 
Published: January 2020

AbstractIdentification of efficient cathode materials represents a huge challenge for development of reversible Mg‐ion batteries (MIBs). Herein, we report on the preparation of copper molybdenum sulfide (Cu2MoS4) in a novel microstructure, namely nanotube with the square‐cross‐section, and its use as a cathode material for Mg‐ion battery. The Cu2MoS4 nanotube was prepared via a one‐pot hydrothermal method using Cu2O nanocubes as a sacrificial template. The Cu2MoS4 nanotube belongs to the top‐tier MIBs cathode materials that shows a remarkable specific capacity of 390.5 mAh g−1.
Progress in Reactions of N‐Isocyanoiminotriphenylphosphorane
Authors: Wang Yeming , Zhang Chaoqun 
Published: January 2020

AbstractN‐isocyanoiminotriphenylphosphorane has been widely applied in diverse organic synthesis due to the favorable structure of isocyano neighbouring iminophosphorane. In this manuscript, we have reviewed the reactions involving N‐isocyanoiminotriphenylphosphorane including insertion reactions, cyclization reactions and multicomponent reactions in last twenty years, as well as the reaction mechanism has been illustrated clearly.
A Cu(II)‐Inorganic Co−Crystal as a Versatile Catalyst Towards ‘Click’ Chemistry for Synthesis of 1,2,3‐triazoles and β‐hydroxy‐1,2,3‐triazoles
Authors: Ghosh Debasish , Dhibar Subhendu , Dey Amiya , Manna Priyanka , Mahata Partha , Dey Biswajit 
Published: January 2020

AbstractA novel Cu(II) inorganic co‐crystal (CuICC) i. e. {[Cu(IMA)(2,2′‐bipyridine)(H2O)]2 ⋅ [Cu2(IMA)2(2,2′‐bipyridine)2] ⋅ 6H2O} [where IMA=isopropylmalonic acid] has been synthesized. The inorganic co‐crystal of Cu(II) has been exploited as the versatile efficient catalyst for the cost effective facile synthetic approaches towards ‘click’ reaction which is effective for the several marked organic syntheses of 1,2,3‐triazoles and β‐hydroxy‐1,2,3‐triazoles. The catalytic process was performed through the single pot reaction based aerial synthetic protocol that does not need to perform any chromatographic purification technique. Interestingly, the CuICC acts as heterogeneous catalyst for the synthesis of 1,2,3‐triazoles, whereas its homogeneous catalytic role has been found for the synthesis of β‐hydroxy‐1,2,3‐triazoles.
Oxidative Addition of C–X Bonds and H–H Activation Using PNNP‐Iron Complexes
Authors: Gautam Monika , Yatabe Takafumi , Tanaka Shinji , Satou Naoto , Takeshita Tomohiro , Yamaguchi Kazuya , Nakajima Yumiko 
Published: January 2020

AbstractIron(0) complex bearing a phenanthroline‐based meridional PNNP ligand [{Fe(PNNP)}2(μ‐N2)] (1) (PNNP=2,9‐bis((diphenylphosphino)methyl)‐1,10‐phenanthroline) smoothly reacted with CH3I at ambient temperature to cleave C–I bond, resulting in the formation of the corresponding oxidative addition product, [Fe(CH3)(I)(PNNP)] (2). Complex 2 was fully identified by NMR and its structure was determined by a single crystal X‐ray diffraction study. Mechanistic study using cyclopropylmethyl bromide as a radical clock supported a radical pathway for the C–I bond cleavage of CH3I. Complex 2 underwent deprotonation on treatment with NaOtBu to form 4, which possessed a dearomatized phenanthroline backbone. Complex 4 further reacted with H2 to cleave H–H bond. The reaction was mediated by metal‐ligand cooperation process that involves re‐aromatization of the phenanthroline backbone of the PNNP ligand.
How Peptides Dissociate in Plasmonic Hot Spots
Authors: Szczerbiński Jacek , Metternich Jonas B. , Goubert Guillaume , Zenobi Renato 
Published: January 2020

AbstractPlasmon‐induced hot carriers enable dissociation of strong chemical bonds by visible light. This unusual chemistry has been demonstrated for several diatomic and small organic molecules. Here, the scope of plasmon‐driven photochemistry is extended to biomolecules and the reactivity of proteins and peptides in plasmonic hot spots is described. Tip‐enhanced Raman spectroscopy (TERS) is used to both drive the reactions and to monitor their products. Peptide backbone bonds are found to dissociate in the hot spot, which is reflected in the disappearance of the amide I band in the TER spectra. The observed fragmentation pathway involves nonthermal activation, presumably by dissociative capture of a plasmon‐induced hot electron. This fragmentation pathway is known from electron transfer dissociation (ETD) of peptides in gas‐phase mass spectrometry (MS), which suggests a general similarity between plasmon‐induced photochemistry and nonergodic reactions triggered by electron capture. This analogy may serve as a design principle for plasmon‐induced reactions of biomolecules.
Charge density response and fake plasmons in holographic models with strong translation symmetry breaking
Authors: Andrade Tomas , Krikun Alexander , Romero-Bermúdez Aurelio 
Published: January 2020

Abstract

We study the charge density response in holographic models with explicit trans- lation symmetry breaking which is relevant in IR. In particular, we focus on Q-lattices and the Bianchy VII helix. We show that the hydrodynamic sound mode is removed from the spectrum due to the strong momentum relaxation and therefore, the usual treatment of the plasmon as Coulomb-dressed zero sound does not apply. Furthermore, the dominant coherent modes in the longitudinal channel, which control the neutral density-density correlator, are the diffusive modes. We show these modes are strongly suppressed when the boundary Coulomb interaction is turned on. This renders the low frequency charge density response spectrum completely incoherent and featureless.
At intermediate frequencies, we observe a broad feature — the fake plasmon — in the dressed correlator, which could be confused with an overdamped plasmon. However, its gap is set by the scale of translation symmetry breaking instead of the plasma frequency. This broad feature originates from the non-hydrodynamic sector of the holographic spectrum, and therefore, its behaviour, typical of strongly correlated quantum critical systems with holographic duals, deviates from the standard Fermi-liquid paradigm.
Effects of once-weekly semaglutide vs once-daily canagliflozin on body composition in type 2 diabetes: a substudy of the SUSTAIN 8 randomised controlled clinical trial
Authors: McCrimmon Rory J. , Catarig Andrei-Mircea , Frias Juan P. , Lausvig Nanna L. , le Roux Carel W. , Thielke Desirée , Lingvay Ildiko 
Published: January 2020

Abstract
Aims/hypothesis
Intra-abdominal or visceral obesity is associated with insulin resistance and an increased risk for cardiovascular disease. This study aimed to compare the effects of semaglutide 1.0 mg and canagliflozin 300 mg on body composition in a subset of participants from the SUSTAIN 8 Phase IIIB, randomised double-blind trial who underwent whole-body dual-energy x-ray absorptiometry (DXA) scanning.

Methods
Adults (age ≥18 years) with type 2 diabetes, HbA1c 53–91 mmol/mol (7.0–10.5%), on a stable daily dose of metformin (≥1500 mg or maximum tolerated dose) and with an eGFR ≥60 ml min−1 [1.73 m]−2 were randomised 1:1 to semaglutide 1.0 mg once weekly and canagliflozin placebo once daily, or canagliflozin 300 mg once daily and semaglutide placebo once weekly. Body composition was assessed using whole-body DXA scans. The study participants and investigator remained blinded throughout the trial, and quality of DXA scans was evaluated in a blinded manner. Change from baseline to week 52 in total fat mass (kg) was the confirmatory efficacy endpoint.

Results
A subset of 178 participants (semaglutide, n = 88; canagliflozin, n = 90) underwent DXA scanning at screening and were randomised into the substudy. Of these, 114 (semaglutide, n = 53; canagliflozin, n = 61) participants had observed end-of-treatment data included in the confirmatory efficacy analysis. Of the 178 participants in the substudy, numerical improvements in body composition (including fat mass, lean mass and visceral fat mass) were observed after 52 weeks with both treatments. Total fat mass (baseline 33.2 kg) was reduced by 3.4 kg and 2.6 kg with semaglutide and canagliflozin, respectively (estimated treatment difference: –0.79 [95% CI −2.10, 0.51]). Although total lean mass (baseline 51.3 kg) was also reduced by 2.3 kg and 1.5 kg with semaglutide and canagliflozin, respectively (estimated treatment difference: −0.78 [−1.61, 0.04]), the proportion of lean mass (baseline 59.4%) increased by 1.2%- and 1.1%-point, respectively (estimated treatment difference 0.14 [−0.89, 1.17]). Changes in visceral fat mass and overall changes in body composition (assessed by the fat to lean mass ratio) were comparable between the two treatment groups.

Conclusions/interpretation
In individuals with uncontrolled type 2 diabetes on stable-dose metformin therapy, the changes in body composition with semaglutide and canagliflozin were not significantly different. Although numerical improvements in body composition were observed following treatment in both treatment arms, the specific impact of both treatments on body composition in the absence of a placebo arm is speculative at this stage.

Trial registration
ClinicalTrials.gov NCT03136484.

Funding
This trial was supported by Novo Nordisk A/S, Denmark.
Mental disorders and suicidal behavior in refugees and Swedish-born individuals: is the association affected by work disability?
Authors: Björkenstam Emma , Helgesson Magnus , Amin Ridwanul , Lange Theis , Mittendorfer-Rutz Ellenor 
Published: January 2020

Abstract
Background
Among potential pathways to suicidal behavior in individuals with mental disorders (MD), work disability (WD) may play an important role. We examined the role of WD in the relationship between MD and suicidal behavior in Swedish-born individuals and refugees.

Methods
The study cohort consisted of 4,195,058 individuals aged 16–64, residing in Sweden in 2004–2005, whereof 163,160 refugees were followed during 2006–2013 with respect to suicidal behavior. Risk estimates were calculated as hazard ratios (HR) with 95% confidence intervals (CI). The reference groups comprised individuals with neither MD nor WD. WD factors (sickness absence (SA) and disability pension (DP)) were explored as potential modifiers and mediators.

Results
In both Swedish-born and refugees, SA and DP were associated with an elevated risk of suicide attempt regardless of MD. In refugees, HRs for suicide attempt in long-term SA ranged from 2.96 (95% CI: 2.14–4.09) (no MD) to 6.23 (95% CI: 3.21–12.08) (MD). Similar associations were observed in Swedish-born. Elevated suicide attempt risks were also observed in DP. In Swedish-born individuals, there was a synergy effect between MD, and SA and DP regarding suicidal behavior. Both SA and DP were found to mediate the studied associations in Swedish-born, but not in refugees.

Conclusion
There is an effect modification and a mediating effect between mental disorders and WD for subsequent suicidal behavior in Swedish-born individuals. Also for refugees without MD, WD is a risk factor for subsequent suicidal behavior. Particularly for Swedish-born individuals with MD, information on WD is vital in a clinical suicide risk assessment.
Multilinear Maps from Obfuscation
Authors: Albrecht Martin R. , Farshim Pooya , Han Shuai , Hofheinz Dennis , Larraia Enrique , Paterson Kenneth G. 
Published: January 2020

AbstractWe provide constructions of multilinear groups equipped with natural hard problems from indistinguishability obfuscation, homomorphic encryption, and NIZKs. This complements known results on the constructions of indistinguishability obfuscators from multilinear maps in the reverse direction. We provide two distinct, but closely related constructions and show that multilinear analogues of the $${\text {DDH}} $$DDH assumption hold for them. Our first construction is symmetric and comes with a $$\kappa $$κ-linear map $$\mathbf{e }: {{\mathbb {G}}}^\kappa \longrightarrow {\mathbb {G}}_T$$e:Gκ⟶GT for prime-order groups $${\mathbb {G}}$$G and $${\mathbb {G}}_T$$GT. To establish the hardness of the $$\kappa $$κ-linear $${\text {DDH}} $$DDH problem, we rely on the existence of a base group for which the $$\kappa $$κ-strong $${\text {DDH}} $$DDH assumption holds. Our second construction is for the asymmetric setting, where $$\mathbf{e }: {\mathbb {G}}_1 \times \cdots \times {\mathbb {G}}_{\kappa } \longrightarrow {\mathbb {G}}_T$$e:G1×⋯×Gκ⟶GT for a collection of $$\kappa +1$$κ+1 prime-order groups $${\mathbb {G}}_i$$Gi and $${\mathbb {G}}_T$$GT, and relies only on the 1-strong $${\text {DDH}} $$DDH assumption in its base group. In both constructions, the linearity $$\kappa $$κ can be set to any arbitrary but a priori fixed polynomial value in the security parameter. We rely on a number of powerful tools in our constructions: probabilistic indistinguishability obfuscation, dual-mode NIZK proof systems (with perfect soundness, witness-indistinguishability, and zero knowledge), and additively homomorphic encryption for the group $$\mathbb {Z}_N^{+}$$ZN+. At a high level, we enable “bootstrapping” multilinear assumptions from their simpler counterparts in standard cryptographic groups and show the equivalence of PIO and multilinear maps under the existence of the aforementioned primitives.
Influence of machining parameters on the polymer concrete milling process
Authors: Kepczak Norbert , Zgorniak Piotr , Lajmert Paweł , Rosik Radoslaw , Sikora Malgorzata 
Published: January 2020

AbstractThe paper examines the wear of end mill cutters, the parameters of a workpiece’s surface layer and the values of cutting forces during the machining of polymer concrete, which is one of the most difficult-to-cut materials. Increased abrasive wear of the active cutting edges is a result of the heterogeneous structure of this material, and it has a negative effect on the cutting process, the durability of the cutting tools as well as the roughness of the workpiece. It is very important to determine the machining parameters for this material from a tool durability and quality of machining point of view. The research was divided into two stages. In the first stage, the appropriate machining parameters were determined based on the measurement of the components of the cutting force. In the second stage, durability tests of four end mill cutters were carried out. During the tests, the component cutting forces, tool wear and surface roughness were measured. The highest tool durability was recorded for the monolithic cemented carbide cutter with coating NC Mill G9F42120N 4F. Tools made of high-speed steel should not be used for machining polymer concrete, as they exhibited the highest intensity of tool wear. The rapid loss of machinability of these tools leads to a rapid increase in cutting force and the roughness of the machined surface. From an economic point of view, cemented carbide end mill cutters with coatings seem to be the appropriate choice for machining polymer concrete.
Single‐Port Laparoscopic Repair of Perforated Duodenal Ulcers
Authors: Nguyen Tri Huu , Dang Thanh Nhu , Schnelldorfer Thomas 
Published: January 2020

AbstractBackgroundLaparoscopic single‐port surgery has widely been introduced for the treatment of various abdominal conditions. But controversies still exist regarding its potential advantages and risks, especially for emergency surgery. The aim of this study was to evaluate the results of a single‐port laparoscopic repair using straight laparoscopic instruments for the treatment of perforated duodenal ulcers.MethodsA prospective consecutive case series was conducted including all patients with a perforated duodenal ulcer who underwent a laparoscopic single‐port repair at a single institution from January 2012 to June 2018. The operation was performed through a single port using conventional straight laparoscopic instruments and intra‐corporeal knot tying techniques.ResultsOut of 75 patients, simple closure of the perforation without omental patch was accomplished in 96% of cases. Conversion to an open operation was required in one patient (1.3%) due to a posterior duodenal perforation, and additional trocar placement was needed in another patient (1.3%). The mean incision length was 2.0 ± 0.2 cm. The mean operation time was 63.0 ± 26.6 min. Meantime a nasogastric tube remained in place was 2.9 ± 0.8 days. Mean duration of analgesic use was 2.8 ± 0.8 days. The rate of postoperative complications was 2.7%, including two patients with wound infections. There were no instances of intestinal leak or abscess. The postoperative hospital stay was 5.7 ± 1.2 days.ConclusionLaparoscopic single‐port repair using conventional straight laparoscopic instruments with intra‐corporeal knot tying technique was safe and feasible for patients with perforated duodenal ulcers with low risk factors. This method offers results comparable to those expected with the standard multiport laparoscopic approach with the addition of improved cosmetic outcomes.
Preoperative elevated E/e’ (≥ 15) with preserved ejection fraction is associated with the development of postoperative heart failure in intermediate-risk non-cardiac surgical patients
Authors: Higashi Midoriko , Shigematsu Kenji , Tominaga Kenji , Murayama Kazuya , Seo Daisuke , Tsuda Toshikazu , Maruta Gen , Iwashita Kohei , Yamaura Ken 
Published: January 2020

Abstract
Purpose
Left ventricular diastolic dysfunction is an independent risk factor for adverse cardiovascular morbidities and mortalities in cardiovascular and high-risk surgical patients. However, there were only a few investigations among intermediate-risk surgical patients. This study aimed to investigate postoperative heart failure (HF) in intermediate-risk surgical patients who had preoperative diastolic dysfunction with preserved ejection fraction (EF).

Methods
Consecutive patients underwent intermediate-risk surgery between January 2016 and December 2018 were retrospectively evaluated. Patients with preserved EF were divided into three groups using one of the parameters of diastolic function: the ratio of early diastolic filling velocity to the peak diastolic velocity of mitral medial annulus (E/e’) ≥ 15, E/e’ between 8 and 15, and E/e’ < 8. Postoperative HF was defined as clinical symptoms and radiological evidence and low SpO2 less than 93%. The primary outcome was the incidence of postoperative HF and its relation to preoperative E/e’. Chi-squared test, unpaired t test with Welch’s correction, and multivariate logistic regression were used for analysis.

Results
In total, 965 patients were included in the final analysis. Postoperative HF developed in 36/965 (3.7%) patients with preserved EF. The incidence of postoperative HF was stratified according to the E/e’, and the rates of HF occurrence in patients with E/e’ < 8, 8–15, and ≥ 15 were 1.8%, 2.7%, and 15%, respectively (P < 0.01).

Conclusion
Preoperative elevated E/e’ (≥ 15) was associated with the development of postoperative HF in intermediate-risk surgical patients with preserved EF.
Let us integrate sexual health—do psychiatrists integrate sexual health in patient management?
Authors: Seitz Tamara , Ucsnik Lucia , Kottmel Andrea , Bitzer Johannes , Teleky Bela , Löffler-Stastka Henriette 
Published: January 2020

AbstractThe high prevalence of sexual dysfunction and the importance of sexual health issues in general stress the need for a physician to integrate sexual health issues in patient management. In this study, we evaluate the frequency of psychiatrists addressing sexual health issues as well as their attitude towards sexual health. Plus, we want to evaluate the multi-professional network for patient treatment that is needed by physicians for collaboration with other medical specialists and health care professionals. At total 100 psychiatrists (age range 30–60 years), participating at the annual meeting of the Austrian Society of Psychiatry, Psychotherapy, and Psychosomatics, were invited to self-assess their caring for patients’ sexual health issues and answer a self-report questionnaire. The return rate was 74%. A third of the participating psychiatrists and psychotherapists stated to address sexual health in patients in daily routine. Twenty-five percent of the physicians suspected sexual health problems in 60–100% of their patients but did not ask the patients about this topic. Mentioned reasons why patients would not actively address sexual problems were rated by the survey participants “a different problem was more important”, “lack of time”, and “embarrassment”. Only few of the participating psychiatrists stated to offer a consultation in sexual health to the patients, none to offer sexual therapy. A mentioned reason was “lack of competence regarding sexual health”. Twelve percent referred the patients with sexual issues to a physician with another medical specialization, especially to experts in gynaecology and obstetrics, to experts in urology, or to andrologists. However, a need for a network in the field of sexual medicine was stated and an unawareness of a sexual health care network: where to refer the patients in need. Our data showed an increased need in the routine treatment and management of sexual health care in psychiatrists and psychotherapists. Plus, the data stresses the need for professional sexual medicine qualification and for extended cooperation between different medical fields and health care professionals in order to integrate sexual health topics professionally in daily routine.