bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adaptation of WHO Definitions of Clinical Forms of Chikungunya Virus Infection for the Elderly
Authors: Godaert Lidvine , Cofais Cécilia , Hequet Fanny , Proye Emeline , Kanagaratnam Lukshe , Césaire Raymond , Najioullah Fatiha , Dramé Moustapha 
Published: December 2020

ABSTRACTThe WHO defined three clinical forms for chikungunya virus infection (CHIKV, namely, acute, atypical, and severe cases) and a chronic form. These definitions seemed inappropriate for the elderly. So, we propose an adapted definition for elderly people. A cross-sectional analysis was performed including patients aged ≥ 65 years, who attended the emergency department with a positive biological diagnosis of CHIKV in 2014. A total of 267 elderly patients (80 ± 8 years) were included. When using the 2015 WHO definitions, 114 patients could not be classified (42.7%) in any of the category, of whom 43 (37.7%) reported absence of fever, 85 (74.6%) reported absence of joint pain, and 14 (12.3%) reported absence of both fever and joint pain. After adaptation of the WHO definitions, the 114 unclassifiable patients were reclassified as follows: eight as typical cases, 50 as atypical cases, 42 as severe cases, and 14 remained unclassifiable. The atypical clinical form was the most common form. The 2015 WHO definitions of the clinical forms at the acute phase of CHIKV are ill suited to the elderly. The adapted definition we propose here appears to be more appropriate and could help improved management of older patients with CHIKV.
PROCESOS ADMINISTRATIVOS Y SU INCIDENCIA EN EL DEPARTAMENTO DE PLANIFICACIÓN Y TERRITORIO DEL GOBIERNO AUTÓNOMO DESCENTRALIZADO DEL CANTÓN JIPIJAPA.
Authors: Almendariz Menendez Jocelyne Zuleika , Proaño Ponce William Patricio 
Published: December 2020

El presente trabajo de investigación con el tema “Procesos Administrativos y su incidencia en el departamento de Planificación y territorio del Gobierno Autónomo Descentralizado del cantón Jipijapa durante el periodo 2018”, cuyo objetivo principal es diseñar una propuesta de auditoria en las variables mencionadas, esto se logró alcanzar mediante los objetivos específicos: Identificar los fundamentos teóricos y metodológicos asociados a los procesos administrativos, diagnosticar los procesos administrativos que se desarrollan en el departamento y diseñar los componentes y relaciones esenciales de la propuesta de auditoria a los procesos para el desarrollo de las actividades que se realizan en el departamento. Se diseñará una auditoria de control interno porque mediante su aplicación nos permitirá conocer la situación actual en la que se encuentra el departamento y a su vez verificar el grado de desempeño del personal que labora dentro del mismo. La evaluación de control interno ayuda al auditor a llegar obtener una importancia y relevancia a los procesos administrativos que se llevan a cabo dentro del departamento. Para llegar al principal objetivo de esta auditoria es evaluar el sistema de control interno y las etapas de los procesos administrativos como: planeación, organización, dirección y control, ya que estas etapas son elementos fundamentales que influyen en la gestión de los procesos. Por lo tanto, un control interno es de importante responsabilidad dentro de la administración del departamento de planificación y territorio del GAD municipal del cantón Jipijapa, ya que mediante su aplicación se determinará la situación del departamento misma que conlleva a verificar si existen falencias y en caso d haberlas emitir las respectivas recomendaciones, esto ayudará de tal manera al crecimiento organizacional de la institución.
"A paixão pelo possível" em educação comparada e internacional
Authors: Cortina Regina 
Published: December 2020

Este artigo interroga a direcionalidade Norte-Sul da produção de conhecimento no campo da Educação Comparada e Internacional. Com base em um arcabouço teórico desenvolvido no Sul, descreve as mudanças que ocorrem nos países da América Latina e que afirmam a diversidade e a mistura (mestizaje) cultural, étnica e racial que há muito caracterizam as Américas. Também questiona as Ciências Sociais ocidentais e seu domínio sobre as estruturas de análise para compreender as sociedades e culturas latino-americanas. O artigo ainda convida pesquisadores a interromper a destruição do conhecimento indígena, ocorrida por meio da imposição do regime epistêmico dominante, e encoraja-os a desenvolver o pensamento decolonial e paradigmas de pesquisa que contestem a hierarquia Norte-Sul na produção de conhecimento, a fim de promover igualdade e justiça nas comunidades locais e globais.
A interação comunicativa na lenda do cabeça de cuia: um estudo na perspectiva da ecolinguística
Authors: Lacerda Naziozênio Antonio 
Published: December 2020

A interação comunicativa é o ponto central da língua e ocorre no interior do ecossistema linguístico. Assim, o objetivo desta pesquisa é analisar a interação comunicativa no ecossistema linguístico da lenda do cabeça de cuia. Para fundamentação da pesquisa, busca-se embasamento teórico nos estudos de Couto (2007, 2013, 2015 e 2016) e em Couto e Couto (2019) sobre ecolinguística e seu ramo denominado linguística ecossistêmica; e nos trabalhos de Magalhães (2011) e Silva (1982) sobre a lenda do cabeça de cuia. Na metodologia da pesquisa, assume-se uma visão holística, parte-se de uma abordagem qualitativa e adota-se a ecometodologia, usando-se o método da focalização. Os resultados revelam que a interação comunicativa ocorre no meio ambiente natural, no meio ambiente mental e no meio ambiente social do ecossistema integral da lenda do cabeça de cuia, sendo mais marcante no meio ambiente mental, com diálogos que levam a interações entre as conexões dos neurônios (P2) e os cérebros/mentes (T2) dos interlocutores. Constata-se que a lenda do cabeça de cuia está associada às transformações que ocorreram na região para a fundação de Teresina, a nova capital do estado do Piauí, marcadas pelas propriedades: inter-relações, adaptação, evolução e integração, identificadas na análise das interações do ecossistema linguístico integral. Conclui-se que a interação comunicativa no ecossistema linguístico da lenda constitui uma comunidade de fala simples, em que as pessoas (p1 e p2) usam a língua portuguesa para a interação pessoa-pessoa, caracterizada pela desarmonia no diálogo entre falantes e ouvintes, gerando uma descomunhão.
Resistência em campo de batalha: a vida dos marginalizados em Capão Pecado
Authors: Pereira da Silva Francinaldo , De Sousa Almeida Lucélia 
Published: December 2020

Este artigo propõe uma reflexão acerca da vida e da representação cultural dos marginalizados na obra Capão Pecado, bem como as relações culturais que constitui diálogos conflituosos. O principal foco é apresentar como o romance trabalha a resistência da cultura periférica em um campo de batalha contra a influência de fatores externos à comunidade. Diante disso, objetiva-se, de modo geral, analisar os discursos que se desenvolve ao longo da obra como pontos de resistência à massificação cultural. De modo específico; mostrar como a literatura marginal tem reivindicado um espaço na produção literária que dê voz aos moradores marginalizados, perceber o trabalho discursivo na busca de uma afirmação sociocultural, posto como militância, e evidenciar a luta contra fatores sociais que condicionam a localidade periférica a percorrer a criminalidade. Assim, para o desenvolvimento do presente estudo, a metodologia apresentada compõe uma pesquisa bibliográfica de cunho explicativo, na qual utiliza-se como pressupostos teóricos os postulados Dalcastagné (2007), Tamagnone (2013), Goffman (1985), Fianco (2010), Hall (2006), entre outros. Como resultados obtidos, constatou-se que a obra apresenta um aparato discursivo que reflete sobre as condições que enquadra a vida dos moradores de periferia a uma realidade cotidiana, na qual a criminalidade se constitui com um produto cultural de pobreza ao lado da cultura do hip-hop, ao mesmo tempo que essas localidades buscam seus direitos e sua singularidade, sobre constante luta as influências externas que tende ao apagamento de sua subjetividade através da alienação cultural.
Scientific drilling workshop on the Weihe Basin Drilling Project (WBDP): Cenozoic tectonic–monsoon interactions
Authors: An Zhisheng , Zhang Peizhen , Vogel Hendrik , Song Yougui , Dodson John , Wiersberg Thomas , Feng Xijie , Lu Huayu , Ai Li , Sun Youbin 
Published: December 2020

Abstract. The Weihe Basin, enclosed by the Chinese Loess Plateau to the north and the Qinling Mountains to the south, is an outstanding, world-class continental site for obtaining high-resolution multi-proxy records that reflect environmental changes spanning most of the Cenozoic. Previous geophysical and sedimentary studies indicate that the basin hosts 6000–8000 m thick fluvial–lacustrine sedimentary successions spanning the Eocene to Holocene. This sedimentary record provides an excellent and unique archive to decipher long-term tectonic–climate interactions related to the uplift of the Tibetan Plateau, the onset/evolution of the Asian monsoon, and the development of the biogeography of East Asia. Owing to its location at the interface of the opposing westerly and Asian monsoon circulation systems, the Weihe Basin also holds enormous promise for providing a record of changes in these circulation systems in response to very different boundary conditions since the Eocene. To develop an international scientific drilling programme in the Weihe Basin, the Institute of Earth Environment, Chinese Academy of Sciences, organized a dedicated workshop with 55 participants from eight countries. The workshop was held in Xi'an, China, from 15 to 18 October 2019. Workshop participants conceived the key scientific objectives of the envisaged Weihe Basin Drilling Project (WBDP) and discussed technical and logistical aspects as well as the scope of the scientific collaboration in preparation for a full drilling proposal for submission to the International Continental Scientific Drilling Program (ICDP). Workshop participants mutually agreed to design a two-phase scientific drilling programme that will in a first phase target the upper 3000 m and in a second phase the entire up to 7500 m thick sedimentary infill of the basin. For the purpose of the 7500 m deep borehole, the world's only drill rig for ultra-deep scientific drilling on land, Crust 1, which previously recovered the entire continental Cretaceous sediments in the Songliao Basin, will be deployed in the WBDP.
Acute Hepatopathy in a Dog Secondary to Hypothyroidism-Induced Atherosclerotic Infarction and Necrosis
Authors: Bolton Timothy Andrew 
Published: December 2020

ABSTRACTA 7 yr old male beagle was examined because of lethargy, anorexia, and cranial abdominal discomfort. Significant clinicopathologic abnormalities included severe liver enzyme elevations and hypercholesterolemia. Abdominal imaging identified vascular compromise of the left lateral liver lobe and a gallbladder mucocele. Following liver lobectomy and cholecystectomy, the dog’s clinical signs resolved, and liver enzymes substantially improved. Diffuse hepatocellular infarction and necrosis secondary to multifocal atherosclerosis was present on histopathology of the liver. Hypothyroidism was subsequently diagnosed. Restoration of euthyroidism with oral levothyroxine therapy resolved the remaining liver enzyme elevations and hypercholesterolemia. To the author’s knowledge, this is the first case report of hypothyroidism resulting in a clinically apparent and resolvable acute hepatopathy due to atherosclerosis. Clinicians should include atherosclerosis as a differential diagnosis for dogs with an acute hepatopathy and investigate dogs for hypothyroidism if atherosclerosis is diagnosed on liver biopsy.
High Density Planting System of Cotton in India: Status and Breeding Strategies
Authors: Kumar Mahadevan , Premalatha Nallathambi , Mahalingam Lakshmanan , Sakthivel Nalliappan , Senguttuvan Kannan , Latha Paramanandham 
Published: December 2020

Cotton, a crop of choice, occupies the second premier position next to food crops in providing clothing. Though 53 species of Gossypium are available, only four species are cultivable and among the four, the major cultivable area falls under G. hirsutum. Though varieties with medium, superior medium, long and extra long staple cotton were released earlier, with the advent of machineries, ginning facilities, mills were literally requiring cotton fiber of any length. With the advent of Bt technology and the release of hybrids during 2002, cotton productivity had a momentum. However, considering the duration, cost involved in manual harvesting etc., farmers were looking for alternate option and High Density Planting System (HDPS) offered a promise in this direction. Farmers were looking for genotypes that could yield better under higher planting densities with fewer bolls per plant, synchronized maturity with uniform bursting. Efforts have been taken all over the World in this direction and India is not an exception. Handful of varieties fitting to this situation has been released from many of the Universities. This chapter essentially summarizes the genetic, agronomic, plant protection interventions and the futuristic requirements for achieving at least 700 kg of lint per hectare.
Parasitoids of the genus Pholetesor Mason, 1981 (Hymenoptera: Braconidae: Microgastrinae) from the leafminers Lepidoptera, with the description of three new species from India
Authors: Ahmad Zubair , Ghramh Hamed A. , Pandey Kavita 
Published: December 2020

Pholetesor acrocercophagus sp. nov., P. camerariae sp. nov. and P. indicus sp. nov.(Hymenoptera: Braconidae: Microgastrinae) are described as new to science. These three species were reared from Acrocercops sp., Acrocercops phaeospora Meyrick, 1916 and Cameraria virgulata Meyrick, 1914 (Lepidoptera: Gracillariidae), respectively. Characteristics of these new species and their affinities with related taxa are discussed. Data on habitat, host records and host plant species for all the parasitoid species is provided. A key to the Indian species of the genus Pholetesor Mason, 1981 reared from lepidopteran leafminers is also given.
Copulas in Spanish: Scalar structure and interpretive economy
Authors: Bazaco Carmelo 
Published: December 2020

This article analyzes the distribution of the copulas ser and estar in Spanish, based on a scalar theoretical framework. The main proposal is that their distribution can be captured in terms of the scalar structure of the predicates involved and the presence of cognitive salient points on those scales. The proposed framework centers around ser predicates involving a single degree on the scale, while those with estar involve an interval, which additionally must involve an onset, or salient point.

This analysis has two advantages. First, it accounts for subjects and closed-scale adjective pairs not being able to alternate between ser or estar. The endpoints present on closed-scales act as strong salient points that, based on the Principle of Interpretive Economy, require that the copula estar is used if it can. Second, this analysis also accounts for the distribution of estar with open-scale predicates and explains why adjectives like famoso ‘famous’ or rico ‘rich’ are virtually absent from estar predications, despite having the appropriate temporal reading. Cognitive salient points are also responsible for generating the appropriate scalar interval required for estar predications, although their being weaker than endpoints on closed-scales does not require estar be the only copula available. The article also accounts for the nature of these onsets on open-scale adjectives and provides a diagnostic tool to determine which adjectives have them, and consequently can appear in estar predications.
Generalized Hadamard Matrices and 2-Factorization of Complete Graphs
Authors: Nishadi W. V. , Perera A. A. I. 
Published: December 2020

Graph factorization plays a major role in graph theory and it shares common ideas in important problems such as edge coloring and Hamiltonian cycles. A factor of a graph is a spanning subgraph of which is not totally disconnected. An - factor is an - regular spanning subgraph of and is -factorable if there are edge-disjoint -factors such that . We shall refer as an -factorization of a graph . In this research we consider -factorization of complete graph. A graph with vertices is called a complete graph if every pair of distinct vertices is joined by an edge and it is denoted by . We look into the possibility of factorizing with added limitations coming in relation to the rows of generalized Hadamard matrix over a cyclic group. Over a cyclic group of prime order , a square matrix of order all of whose elements are the root of unity is called a generalized Hadamard matrix if , where is the conjugate transpose of matrix and is the identity matrix of order . In the present work, generalized Hadamard matrices over a cyclic group have been considered. We prove that the factorization is possible for in the case of the limitation 1, namely, If an edge belongs to the factor , then the and entries of the corresponding generalized Hadamard matrix should be different in the row. In Particular, number of rows in the generalized Hadamard matrices is used to form -factorization of complete graphs. We discuss some illustrative examples that might be used for studying the factorization of complete graphs.
Ocimum Species as Potential Bioresources against COVID-19: A Review of Their Phytochemistry and Antiviral Activity
Authors: Tshilanda Dorothée D. , Ngoyi Etienne M. , Kabengele Carlos N. , Matondo Aristote , Bongo Gedeon N. , Inkoto Clement L. , Mbadiko Clement M. , Gbolo Benjamin Z. , Lengbiye Emmanuel M. , Kilembe Jason T. , Mwanangombo Domaine T. , Kasiama Giresse N. , Tshibangu Damien S. T. , Ngbolua Koto-te-Nyiwa , Mpiana Pius T. 
Published: December 2020

Aim: The aim of this work was to review literature data reported on some species of the Ocimum genus regarding their phytochemistry and antiviral potential in order to show how Ocimum species might be used in the management of COVID-19.
Methodology: Various databases like PubMed, PubMed Central., Science Direct, SCIELO, DOAJ, Science alert, Semantic scholar and Google scholar were used.
Results: Essential oils and extracts of Ocimum species possess the compounds involved in antiviral activity. In addition, this plant contains certain nutrients which boost the immune system. Ocimum genus displayed antiviral activity against several viruses like Herpes Simplex Virus, Human Immunodeficiency Virus, Infectious Hematopoietic Necrosis Virus, Adenovirus, Enterovirus 71, Parainfluenza virus type 3, Hepatitis C virus, etc. Toxicological data indicated that these plants are safe.
Conclusion: Till now, there is no effective treatment of COVID-19. Ethnopharmacology constitutes an alternative approach for the discovery of effective antiviral drugs. The literature survey reveals that Ocimum species exhibit high antiviral activity, and thus can be used as potential bioresources against COVID-19. Molecular docking study of the interaction of some compounds derived from Ocimum species with SARS-CoV-2 protease is in progress in order to identify the potential inhibitors of the virus.
A Novel 3DOM TiO2 Based Multifunctional Photocatalytic and Catalytic Platform for Energy Regeneration and Pollutants Degradation
Authors: Ding Yang , Huang Lina , Barakat Tarek , Su Bao‐Lian 
Published: December 2020

AbstractThe ternary 3D ordered macroporous (3DOM) heterojuncted nanocomposites (platinum/bismuth molybdate/3DOM TiO2: 3DOM‐Pt/Bi2MoO6/TiO2) are designed and synthesized as multifunctional platform for photocatalytic dye degradation, photoelectrocatalytic (PEC) water splitting, and thermal‐catalytic toluene decomposition with high performance. A series of structural, optical, and electronic characterizations demonstrates that the remarkably improved photocatalytic degradation and PEC water splitting activities are attributed to the combined effects of enhanced light harvesting, abundant reactive sites, facile reactants transfer, and efficient charges–holes pair separation. Through optimizing the loading amounts of Pt and Bi2MoO6, it is found that the 1%Pt/10%Bi2MoO6/TiO2 nanocomposite exhibits the highest photocatalytic Rhodamin B (RhB) degradation rate and PEC water splitting activity, which are 10 and 2.2 times higher than that of the titania photonic crystal (PC‐TiO2) photocatalyst, respectively. This work clearly illustrates that the ternary photocatalyst with 3DOM structure and intimate heterostructure can significantly facilitate the transfer of reaction intermediates and the separation of photogenerated carriers. Considering its unique 3DOM structure and excellent photocatalytic/PEC performances, the ternary nanocomposite has been used in catalytic toluene decomposition and inspiringly shows high efficiency, being very promising in thermocatalytic applications. This work provides new solutions in developing new ternary nanocomposites for versatile applications in photocatalytic, photoelectrochemical, and catalytic fields.
Zinc‐Catalyzed Asymmetric Hydrosilylation of Cyclic Imines: Synthesis of Chiral 2‐Aryl‐Substituted Pyrrolidines as Pharmaceutical Building Blocks
Authors: Węglarz Izabela , Michalak Karol , Mlynarski Jacek 
Published: December 2020

AbstractThe first successful enantioselective hydrosilylation of cyclic imines promoted by a chiral zinc complex is reported. In situ generated zinc‐ProPhenol complex with silane afforded pharmaceutically relevant enantioenriched 2‐aryl‐substituted pyrrolidines in high yields and with excellent enantioselectivities (up to 99% ee). The synthetic utility of presented methodology is demonstrated in an efficient synthesis of the corresponding chiral cyclic amines, being pharmaceutical drug precursors to the Aticaprant and Larotrectinib.magnified image
Could the MED13 mutations manifest as a Kabuki‐like syndrome?
Authors: De Nardi Laura , Faletra Flavio , D'Adamo Adamo Pio , Bianco Anna Monica Rosaria , Athanasakis Emmanouil , Bruno Irene , Barbi Egidio 
Published: December 2020

AbstractMED13‐related disorder is a new neurodevelopmental disorder recently described in literature, which belongs to the group of CDK8‐kinase module genes‐associated conditions. It is characterized by variable intellectual disability and/or developmental delays, especially in language. Autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), eye or vision problems, hypotonia, mild congenital hearth abnormalities and dysmorphisms have been described among individuals with MED13 mutations. We report the case of a 13‐year‐old girl who received a previous clinical diagnosis of Kabuki syndrome (KS) without mutations in classic KS genes. After a whole exome sequencing (WES) analysis a de novo missense mutation in MED13 (c.C979T; p.Pro327Ser) was found. This variant has been once described in literature as accountable for a novel neurodevelopmental disorder. The aim of this report is to improve clinical delineation of MED13‐related condition and to explore differences and similarities between KS spectrum and MED13‐related disorders.
Down syndrome on a small Caribbean island: an uphill battle to obtain services and care for affected individuals
Authors: Nelson Beverly , Lanza‐Perea Marta , Brathwaite Jozan , Hyacinth Tonya , Audain‐Miller Allison , Pierre Anne , Sobering Andrew K. 
Published: December 2020

AbstractMost of the geographically isolated island nations in the Caribbean have small populations and low gross national product. As such, many lack important medical and community services. Difficulties are compounded when attempting to care for children with special needs and genetic disorders such as Down syndrome. International charitable organizations can help to provide much needed specialty medical care. Community associations can encourage local relationship building and education. Collaborative efforts with well‐funded laboratories can help to deliver molecular characterization for individuals who have genetic disorders. With community and volunteer effort, a higher standard of care is obtainable in underserved communities.