bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 Severity: Lung-Heart Interplay
Authors: Puri Gayatri , Singh Vikram P. , Naura Amarjit S. 
Published: December 2020

Abstract:
In December 2019, a novel COVID-19 infection caused by SARS-CoV-2 has emerged
as a global emergency. In a few months, the pathogen has infected millions of people in the world.
Primarily SARS-CoV-2 infects the pulmonary system which ultimately leads to ARDS and lung
failure. The majority of patients develop milder symptoms but the infection turns severe in a huge
number of people, which ultimately results in enhanced mortality in COVID-19 patients. Co-morbid
conditions, primarily cardiovascular complications and diabetes, have been reported to show a
strong correlation with COVID-19 severity. Further, the onset of myocardial injury secondary to
pulmonary damage has been observed in critically ill patients who have never reported heart-related
ailments before. Due to drastic health risks associated with virus infection, the unprecedented
disruption in normal business throughout the world has caused economic misery. Apparently, newer
treatments are urgently needed to combat the virus particularly to reduce the severity burden.
Therefore, understanding the crosstalk between lung and heart during COVID-19 might give us better
clarity for early diagnosis followed by appropriate treatment in patients with the likelihood of
developing severe symptoms. Accordingly, the present review highlights the potential mechanisms
that may explain the crosstalk between lung and heart so that effective treatment/management
strategies can be evolved swiftly in this direction.
Oral Factor Xa (FXa) Inhibitors for Treatment of Heparin-induced Thrombocytopenia (HIT)
Authors: Munafo Nicholas , Patel Sagar , Willett Kristine C. , Morrill Amanda 
Published: December 2020

Background::
Heparin is the most commonly used injectable anticoagulant for many indications,
ranging from the treatment of atrial fibrillation to the prevention of clotting in patients
undergoing surgery. Currently, only argatroban and bivalirudin are FDA approved for the management
of heparin induced thrombocytopenia (HIT) in the United States, both of which are direct
thrombin inhibitors. The agents being reviewed, apixaban and rivaroxaban, are oral direct factor
Xa (FXa) inhibitors. Currently, neither has FDA approval for use in HIT. The objective of this review
is to summarize the current evidence available regarding the use of oral factor Xa inhibitors
for the treatment of HIT.

Methods::
A literature search was conducted using Medline and Ovid Embase. Search terms included
heparin-induced thrombocytopenia, HIT, apixaban, rivaroxaban, Xa Inhibitor, direct thrombin
inhibitor, NOAC, and DOAC. Studies and case reports were included if they evaluated the efficacy
and safety of oral FXa inhibitors for the treatment of HIT. Additional literature and case reports
were found through bibliographic review.

Results and Discussion:
Currently, available literature includes an in vitro study with apixaban,
case reports, and retrospective and prospective cohort studies. The in vitro study evaluated the interaction
between apixaban and platelets in the presence of HIT antibodies, which assessed its potential
for use in HIT management. Fourteen case reports and one case series were also identified, of
which six described treatment with apixaban and eight with rivaroxaban. Lastly, four cohort
studies were published evaluating the use of direct acting oral anticoagulants (DOACs), including
oral factor Xa inhibitors in patients with HIT. Although there are no published randomized control
trials evaluating the use of FXa inhibitors in the management of HIT, there are several findings that
may guide clinicians on the use of these agents in practice.

Conclusion::
As indicated by the case reports, case series and cohort studies detailing clinical use
and described in this manuscript, there are data and positive patient outcomes that support the potential
use of these agents for HIT, and are an impetus for future studies.
Potential Impacts of Prebiotics and Probiotics on Cancer Prevention
Authors: Samanta Saptadip 
Published: December 2020

Background::Cancer is a serious problem throughout the world. The pathophysiology of cancer is multifactorial and is also related to gut microbiota. Intestinal microbes are the useful resident of the healthy human. They play various aspects of human health including nutritional biotransformation, flushing of the pathogens, toxin neutralization, immune response, and onco-suppression. Disruption in the interactions among the gut microbiota, intestinal epithelium, and the host immune system are associated with gastrointestinal disorders, neurodegenerative diseases, metabolic syndrome, and cancer. Probiotic bacteria (Lactobacillus spp., Bifidobacterium spp.) have been regarded as beneficial to health and shown to play a significant role in immunomodulation and displayed preventive role against obesity, diabetes, liver disease, inflammatory bowel disease, tumor progression, and cancer.Objective::The involvement of gut microorganisms in cancer development and prevention has been recognized as a balancing factor. The events of dysbiosis emphasize metabolic disorder and carcinogenesis. The gut flora potentiates immunomodulation and minimizes the limitations of usual chemotherapy. The significant role of prebiotics and probiotics on the improvement of immunomodulation and antitumor properties has been considered.Methods::I had reviewed the literature on the multidimensional activities of prebiotics and probiotics from the NCBI website database PubMed, Springer Nature, Science Direct (Elsevier), Google Scholar database to search relevant articles. Specifically, I had focused on the role of prebiotics and probiotics in immunomodulation and cancer prevention.Results::Prebiotics are the nondigestible fermentable sugars that selectively influence the growth of probiotic organisms that exert immunomodulation over the cancerous growth. The oncostatic properties of bacteria are mediated through the recruitment of cytotoxic T cells, natural killer cells, and oxidative stress-induced apoptosis in the tumor microenvironment. Moreover, approaches have also been taken to use probiotics as an adjuvant in cancer therapy.Conclusion::The present review has indicated that dysbiosis is the crucial factor in many pathological situations including cancer. Applications of prebiotics and probiotics exhibit the immune-surveillance as oncostatic effects. These events increase the possibilities of new therapeutic strategies for cancer prevention.
Nanoremediation: Tiny Objects Solving Huge Environmental Problems
Authors: Rónavári Andrea , Kónya Zoltán 
Published: December 2020

Background:
The application of zero-valent iron nanoparticles (nZVI) to remediate soil and
groundwater has gained increased attention within the last decade, primarily due to their high reactivity,
cost-effectiveness and potential to treat a broad range of contaminants (e.g., chlorinated organic solvents,
inorganic anions, or metals).

Objective:
In this paper, the state of the art of applicability of nanomaterials, especially the most frequently
used nZVI in soil and groundwater, is presented. The purpose of this article is to give an overview
of the current knowledge pertaining to the synthesis, employment, limitations, and risk of iron
nanoparticles.

Methods:
Therefore, the authors have reviewed and discussed the recent patents and papers related to
the developments and approaches made on the synthesis of iron nanoparticles, emphasizing the justification
of green synthesis methods. The studies related to the effective use of nanoparticles in remediating
organic and inorganic contaminants are addressed. The potential limitations, challenges, and risks
of this innovative nanoremediation technology are also discussed.

Results:
Studies suggest that nZVI have successfully been applied in nanoremediation, however little is known about the particles’ fate and impacts. Additionally, it has already been proven that synthesis and modification can largely determine the physicochemical and biological properties of the particles.

Conclusion:
This review corroborates the suitability of nanoparticles in the remediation of contaminated media, simultaneously highlighting the work still needed to optimize the syntheses and careful use of such materials, concluding that comprehensive screenings should be performed prior nZVI applications to assess their behavior and impact on the environment and living systems.
Thespesia populnea: An Ethnomedicinal, Phytochemical and Pharmacological
Review
Authors: Vishwakarma Ashish , Arora Poonam , Dhobi Mahaveer 
Published: December 2020

:
Thespesia populnea, family, Malvaceae, commonly known as paras pipal and Indian tulip tree, is widely
distributed in coastal forests of India and south-eastern areas. The plant is medicinally used for the treatment of numerous
diseases including cutaneous infections, brain and liver disorders.The review summarizes all the information related to
botanical characteristics, traditional uses, chemical components and biological activities of T. populnea, in order to exploit
therapeutic potential of this plant.x.The available information about T. populnea was collected through the online search on
Web of Science, PubMed, Science Direct, Springer and Google Scholar. T. populnea is widely explored concerning its
phytochemistry and biological activities. Amongst all phytoconstituents present in Thespesia, sesquiterpenes and phenolic
compounds are major bioactive ingredients in plant. Experimental studies show that these compounds exhibit a wide range
of biological activities including anti-inflammatory, antidiabetic, analgesic, wound healing, anti-alzheimer, anti-ulcer and
anti-psoriasis in in vitro and in vivo animal studies.To sum up, the plant, T. populnea, possess high medicinal and social
value, that deserves further investigation. T. populnea is promising plant to be utilized in the development of pharmaceutical
drug products. However, there is a lack of scientific studies to confirm its ethnopharmcological uses. In addition, further
studies on isolation of bioactive molecules and their pharmacological studies are recommended that could be of great
significance towards clinical application of this plant.
Potnet: Online Potable Water Quality Monitoring Network for Overhead Water Tanks in Rural Water Supply Schemes in India
Authors: Karuppiah Nagalakshmi , Vaithiyanathasamy Vaishnavee , Raji Anand Babu , Murugaiyan Suresh Valiyurar 
Published: December 2020

Background:
Monitoring the quality of potable water is a challenging endeavor due to the
significant sources of contaminants, the majority of which are human-induced. Limited access to drinking
water owing to acceleration in industrialization, urbanization in consort with growing inhabitants,
unprocessed sewage discharge, and toxic industrial effluents causes different life-threatening diseases.
Manual water quality monitoring techniques vividly aggravate quality deterioration. Considering the
significance of the automatic water quality monitoring system, we need an in-situ, real-time, continuous
surveillance system to ascertain the quality of potable water. Wireless Sensor Network (WSN) motivated
us for a practical water quality monitoring system due to their continuous, real-time, and adaptive
infrastructure to provide an early alert in hazardous conditions.

Objective:
To design and implement an online potable water quality monitoring network for rural water
supply schemes in Nagapattinam district, Tamilnadu, India, to sense physiochemical parameters of potable
water such as pH, turbidity, conductivity and temperature.

Methods:
Online POTable water quality monitoring NETwork (POTNET) integrates the reimbursements
of WSN and different information and communication technologies for data acquisition, data
processing, and data visualization. The core hardware of POTNET contains off-the-shelf sensors (i.e.,
electrodes), a microcontroller, a data transmission system, a customized buoyage, and a sink node. It
senses physiochemical parameters of potable water such as pH, turbidity, conductivity, and temperature
in a pre-programmed time interval. Furthermore, it enables cloud storage for gathered information and
generates an alert to the preregistered user via mobile phones when there is a deviation of quality
measures from threshold values.

Results:
The system was implemented in three overhead tanks for seven days in order to validate the
stability of the buoy and efficiency of energy source, storage, and data transmission. It senses physiochemical
parameters of potable water such as pH, turbidity, conductivity, and temperature in its predefined
interval of 30 minutes. To check the system accuracy, the measured data values from developed
sensors were compared with the observed data values using a commercial multi-parameter water checker,
the Horiba® probe. Measured data were sent through the transceivers to the base station for data
logging in a suitable format for ease of data visualization and utilization.

Conclusion:
Extensive experimental results reveal that our POTNET can be employed for potable water
quality surveillance to help consumers or concern authorities to make a sound decision by providing
appropriate and real-time data.
Formation of Hypercubes Based on Data Obtained from Systems of IoT Devices of Urban Resource Networks
Authors: Duda Oleksii , Matsiuk Oleksandr , Kunanets Nataliia , Pasichnyk Volodymyr , Rzheuskyi Antonii , Bilak Yuriy 
Published: December 2020

Aim:
The aim of this work is to construct a system of interrelated procedures that are used
in the formation of data warehouses for information systems in smart cities.

Objectives:
Currently, the number of IoT devices integrated into the systems of information technology
support of the processes taking place in supply networks of resources of Smart City, is constantly
growing. While functioning, extensive sets of various types of information are generated. Using a single
database, it is not possible to store data sets collected for multiple resource networks on a large
city scale.

Methods:
This work is devoted to the research and improvement of processes of formation of data
hypercubes, which are an informational model of functioning of urban resource networks on the basis
of data coming from systems of IoT devices. Methods of information modeling and construction of
data hypercubes were used in research, taking into account the high dynamics and rapidity of resource
supply processes.

Results:
In this study, mainly the data hypercubes were constructed on the basis of the proposed improved
methods that work based on messages received from real-functioning systems of IoT devices
in urban resource networks. The use of this technology in the framework of information and technological
support of the processes in urban resource networks provides an opportunity for detailed analysis
of the current state of material resources of the city, and identifies trends in their changes and
states by comparing data belonging to different time periods and different by origin collections.

Conclusion:
The basic characteristics of the data warehouse, which provides information about urban
resource networks, are analyzed. The analysis and construction of data hypercubes prototypes on urban
resource networks were carried out. Classification and parameterization of many categories and
attributes were carried out to describe processes in urban resource networks, which allowed, using the
OLAP information technology based on hypercubes, to develop information technology of complex
multidimensional data analysis, obtained using IoT devices that characterize the flow of processes in
the urban resource networks. The obtained results propose the procedures of formation of data hypercubes,
containing information about the progress of urban resource networks, used in the development
of real information systems that collect data using IoT devices. The information technology of process
support in urban resource networks is developed for use in different types of resource networks in the
presence of several providers.
Tradisi Slametan pada Masyarakat Jlatren, Jogotirto Berbah, Sleman, Yogyakarta
Authors: Annisa Naafi , Wardana Amika 
Published: December 2020

Penelitian ini bertujuan mendeskripsikan jenis tradisi slametan, nilai budaya Islam dalam Slametan, dan tahapan pelaksanan Slametan. Penelitian ini menggunakan metode kualitatif deskriptif. Subjek penelitian berjumlah 4 orang, terdiri dari Pemuka Adat dan Agama atau disebut Mbah Kaum, sesepuh desa, dan masyarakat yang masih aktif menjalankan tradisi Slametan, pemilihan informan dengan teknik purposive sampling. Teknik pengumpulan data menggunakan observasi, wawancara, dan dokumentasi. Validitas data menggunakan teknik triangulasi. Teknik analisis data menggunakan analisis Milles dan Huberman. Hasil penelitian ini tradisi slametan terbagi dalam tiga jenis yaitu: Slametan pribadi, Slametan peringatan Hari Besar Agama Islam, dan Slametan yang berkaitan dengan tradisi Dusun. Nilai budaya Islam dalam tradisi Slametan adalah: (1) Perwujudan rasa syukur kepada Tuhan; (2) Memupuk kebiasaan bersedekah.; (3) Sarana penyampaian harapan kepada Tuhan; (4) Menghormati makhluk ghaib. Tahapan pelaksanaan Slametan dimulai dari penentuan tanggal lalu menunjuk perwakilan keluarga untuk menyampaikan undangan lisan Slametan awalnya akan dibuka oleh Rohis / Mbah Kaum serta akan disampaikan tujuan Slametan, pembacaan ayat Al-Qur’an dan doa, ditutup dengan pembagian ubarampe Slametan.
Perubahan Sosial Masyarakat Bantul Pasca Adanya Car Free Day Sebagai Ruang Publik
Authors: Sumardiyanto Aris , Lestari Puji 
Published: December 2020

Penelitian ini bertujuan untuk mengetahui faktor pendorong, bentuk dan dampak perubahan sosial masyarakat Bantul pasca adanya car free day sebagai ruang publik. Metode penelitan ini adalah kualitatif dan pengambilan sampel menggunakan teknik purposive sampling dengan jumlah informan 7 orang. Teknik pengumpulan data menggunakan wawancara, observasi dan dokumentasi. Teknik analisis data yang digunakan adalah teknik analisis data Miles dan Huberman. Hasil penelitian ini menunjukan bahwa faktor pendorong perubahan sosial yang dari dalam adalah sikap terbuka, menghargai dan keinginan untuk maju masyarakat sedangkan faktor pendorong dari luar adalah adanya perubahan fungsi Jalan Jenderal Sudirman Bantul dan sosialisasi dari pengisi acara. Adapun bentuk perubahan sosial yang direncanakan adalah perubahan pola pikir dan pola perilaku masyarakat sedangkan perubahan yang tidak direncanakan adalah perubahan interaksi sosial. Adapun dampak positif meliputi :mempererat hubungan sosial, mengubah perilaku gemar olahraga, mengubah perilaku mengurangi penggunaan kendaraan bermotor dan menambah pengetahuan masyarakat. Adapun dampak negatifnya adalah sampah menumpuk dan munculnya konflik.
Kultur Sekolah Dalam Membentuk Kedisiplinan Siswa di SMA Angkasa Adi Sutjipto Yogyakarta
Authors: Sari Anggi Permata , Pratiwi Poerwanti Hadi , Martiana Aris 
Published: December 2020

Penelitian ini mendeskripsikan kultur sekolah dalam membentuk kedisiplinan siswa di SMA Angkasa Adisutjipto. Penelitian menggunakan metode penelitian kualitatif. Informan pada penelitian ini berjumlah 11 orang. Teknik pemilihan informan menggunakan purposive sampling. Pengumpulan data dengan cara observasi, wawancara dan dokumentasi. Validitas data yang digunakan adalah triangulasi sumber. Teknik Analisis data menggunakan analisis model interaktif Miles Huberman yang meliputi pengumpulan data, reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian ini menunjukkan bahwa disiplin sebagai kultur utama sekolah karena pendidikan di SMA Angkasa berbasis semi militer yang di bimbing TNI AU secara langsung. Selain itu dari artifak fisik seperti; lokasi sekolah berada komplek AURI, seragam siswa lengkap dengan atribut kedirgantaraan, logo sekolah menunjukan berada dibawah naungan AURI. Pada artifak perilaku menunjukkan hubungan yang harmonis antar warga sekolah, yang terlihat dari pola perilaku penerapan 3 S (senyum, salam dan sapa). Temuan terakhir yaitu pada nilai dan keyakinan yang dianut warga sekolah, berupa nilai kejujuran, keteladanan, kedisiplinan dan ketertiban.
Notas necrológicas
Authors: Márquez Yáñez Francisco , Morales Gómez Jorge , Ortiz Sergio Elías 
Published: December 2020

Contiene las siguientes necrológicas:
Resolución número 0008 de 1967 (agosto 3) por la cual se honra la memoria del R. P. Enrique Rochereau.
Franz Termer (1894-1968)
Stanley V. Long (1937-1967)
James A. Ford (1911-1968)
Cestmir Loukotka (1895-1968)
Short-term effects of cover grass intensity on soil microbial communities in an apple orchard
Authors: Wan Pan , Wei Anzhi 
Published: December 2020

Soil microbiota play an important and diverse roles in horticultural
crop nutrition or productivity. However, the soil microbial community
composition and the relationships within the taxa in the microbial
community populations after cover grass treatments in apple orchards are
not well understood. We analysed the microbial community diversity,
composition and microbial network of an apple orchard after covering
with native wild grasses at different intensities for 2 years in the
Loess Plateau, China. The cover grass intensities were 0%, 20%, 40%,
60% and 80%. Soil microbial community diversity was not obviously
change by cover grass in the apple orchard. Cover grass altered the
microbial bacterial community compositions, their changes exhibited
significant differences at the phylum level that were caused by the
Proteobacteria, Bacteroidetes, Chloroflexi, Gemmatimonadetes,
Nitrospirae. However, low-intensity (20%) and moderate-intensity (40%)
treatments were the only cover grass intensities that altered the soil
fungal community composition; but their changes did not exhibit
significant differences at the phylum level. The positive links among
the bacterial taxa decreased with the increasing cover intensity,
primarily among Proteobacteria, Acidobacteria, Actinobacteria,
Chloroflexi and Gemmatimonadetes. Although cover grass increased the
positive links between fungal taxa, these taxa were reduced with the
increasing cover intensity. Here we demonstrate that cover grass changed
the soil microbial community, and the changes may be attributed to the
given phyla in the bacterial community; furthermore, the antagonistic
effect between the soil bacterial and fungal communities was
significantly increased by higher coverage than by lower coverage.
Peningkatan Kompetensi Kaidah Bahasa Arab bagi Pemula Menggunakan Al-Tadrībāt Al-Lughawīyah
Authors: N. Hula Ibnu Rawandhy 
Published: December 2020

This research study is classified as field research with quasi experimental method. The study aims to find out the ability level of the students of Arabic Department graduated non-Islamic Boarding School in doing linguistic exercises (al-Tadriba t al-Lugawiyah) which consists of 12 topics. The steps of the experiment method were started from 1) population, 2) sample, 3) giving materials, 4) giving practice test, 5) data collection (results), 6) data Analysis/ results, and 7) conclusions. The research study yielded two conclusions, namely: 1) Al-tadri ba t al-lugawiyah experiments carried out gradually, systematically and tightly controlled for the students of Arabic Department who were graduated from non-Islamic boarding school were proved to be able to improve their mastery of 12 basic rules of Arabic with presentation: very good: 56.67%, good: 42.78%, fair: 0.56% and poor: 0%. 2) Experiments of al-tadribat al-lugawiyah using Arabic books for beginners were given with 18 types of practice questions, easy and practical in improving their mastery in basic rules of Arabic, with a percentage of 16 students in very good category, (53.3%), 12 students in the good category (40%), 2 students were fair (6.7%) and poor (0%).