bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cluster computing‐aided model updating for a high‐fidelity finite element model of a long‐span cable‐stayed bridge
Authors: Lin Kaiqi , Xu You‐Lin , Lu Xinzheng , Guan Zhongguo , Li Jianzhong 
Published: March 2020

SummaryAccurate and high‐fidelity finite element (FE) models are in great demand in the design, performance assessment, and life‐cycle maintenance of long‐span cable‐stayed bridges. The structural system of a long‐span cable‐stayed bridge is often huge in size and complex with many components connected and various materials constituted. Therefore, the FE model of a long‐span cable‐stayed bridge involves a large number of elements and nodes with many uncertainties. The model updating of the FE model to best represent a real bridge is necessary but very challenging. One of the challenging issues is that the numerical computation needed for searching the global optimum of a large set of structural parameters is so extensive that the existing FE (not surrogate) model‐based updating methods cannot fulfill this task. In this study, a cluster computing‐aided FE model updating framework is proposed for the high‐performance FE model updating of large and complex structures. In the framework, several computer software packages, including MSC.Marc, Python, and MATLAB, are interconnected for making use of their respective functions of strength. The shake table test of a scaled physical structure of the Sutong cable‐stayed bridge in China is used to validate the accuracy and efficiency of the proposed framework. The simulated bridge responses based on the updated FE model are in good agreement with the measured ones from the shake table test. The successful application of the proposed framework provides a reference for the model updating of other types of large and complex structures.
Food addiction in young adult residents of Russia: Associations with emotional and anthropometric characteristics
Authors: Borisenkov Mikhail F. , Popov Sergey V. , Pecherkina Anna A. , Dorogina Olga I. , Martinson Ekaterina A. , Vetosheva Valentina I. , Gubin Denis G. , Solovieva Svetlana V. , Turovinina Elena F. , Symaniuk Elvira E. 
Published: March 2020

AbstractThe incidence of food addiction (FA) and associations between FA and anthropometric and psycho‐emotional characteristics of young Russian adults were studied. In this study, 1,237 students (age, M = 20.6, SD = 4.6 years; 79% females) of universities located in four cities of Russia were attended. They provided demographics and filled in the Yale Food Addiction Scale (YFAS), the Dutch Eating Behavior Questionnaire, and the Zung Self‐Rating Depression Scale. Data were analysed via Chi‐squared tests, logistic regression analysis, and an analysis of covariance. 13.2% of participants met diagnostic criteria for FA based on the YFAS. On average, the participants reported 2.6 FA symptoms (SD = 1.5). FA was more commonly detected in females (OR = 1.86, 95% CI = 1.10, 3.15, p = .021). No relationship was found between age and the incidence of FA. Significant positive associations between FA, the severity of depression (OR = 2.31, 95% CI = 1.91, 2.80, p = .000), and an emotional eating behaviour (OR = 1.45, 95% CI = 1.20, 1.76, p = .000) were found. The waist‐to‐height ratio was found to be the anthropometric indicator most closely associated with FA (OR = 1.49, 95% CI = 1.27, 1.76, p = .000).Highlights
The prevalence of food addiction in the current sample was 13.2%.
In young Russian adults, emotional eating behaviour and depression are associated with food addiction.
In young Russian adults, the waist‐to‐height ratio is the anthropometric indicator most closely associated with food addiction.
Computational fluid dynamic simulation modeling of carbon capture using polyethylenimine impregnated protonated titanate nanotubes
Authors: Kim Hyoung‐Chul , Du Hongbo , Kommalapati Raghava R. , Huque Ziaul , Shen Xinhua 
Published: March 2020

AbstractA comprehensive computational fluid dynamic (CFD) model of CEES‐developed polyethylenimine impregnated protonated titanate nanotubes (PEI‐PTNTs) was developed using the Multiphase Flow with Interphase eXchanges (MFiX) package to evaluate the performance of the PEI‐PTNTs in a 1‐MW pilot‐scale carbon capture reactor developed by the National Energy Technology Laboratory (NETL). In this CFD model, the momentum, continuity, and energy transport equations were integrated with the first‐order chemistry model for chemical kinetics of heterogeneous reactions to predict the adsorption of CO2 onto amine‐based sorbent particles and the reactor temperature. Based on the amount of the CO2 adsorption obtained in the small‐scale experiment, the coefficients for the chemical reaction equations of PEI‐PTNTs are adjusted. The adjusted PEI‐PTNTs model is applied to the simplified numerical model of 1‐MW pilot‐scale carbon capture system, which is calibrated through the comparison between our simulation results and the results provided by NETL. This calibrated CFD model is used for selecting the optimized flow rate of the gas phase. Our study shows that the optimized gas flow rate to absorb 100% CO2 without loss is 1.5 kg/s, but if higher absorption rate is preferable despite some loss of CO2 absorption in the reactor, a higher flow rate than 1.5 kg/s can be selected.
Influence of Soil Phosphate on the Accumulation and Toxicity of Arsenic and Antimony in Choy Sum Cultivated in Individually and Co-contaminated Soils
Authors: Egodawatta Lakmini P. , Holland Aleicia , Koppel Darren , Jolley Dianne F. 
Published: March 2020

Abstract
Fertilizers containing phosphate (PO43−) are commonly used within the agricultural industry and are known to increase the bioavailability and mobility of metalloids like arsenic (As). This may increase plant uptake of As and hence pose a risk to human health. Arsenic and antimony (Sb) often co-occur in contaminated soils; however, little is known about the interactions between As and Sb with PO43− on their bioavailability, accumulation, and toxicity in plants. The present study investigated individual and combined As and Sb–contaminated soils across 2 soil PO43− concentrations using a commonly consumed leafy vegetable, choy sum (Brassica chinensis var. parachinensis). Increased soil PO43− had no clear influence on the bioavailability of As or Sb (derived from a sequential extraction procedure). At high PO43− concentration, B. chinensis accumulated higher amounts of As in the shoots and roots in both individual and co-contaminated soil, whereas Sb accumulation increased only when Sb was the only contaminant. When As was the only contaminant, the translocation of As from roots to shoots decreased as soil PO43− increased. Increased soil PO43− had no influence on Sb translocation from root to shoot. Although As was toxic (impaired growth) at low PO43− soil concentration, no toxicity was observed in the high-PO43− soil. No toxicity was observed for Sb in either low- or high-PO43− soils. Increased soil PO43− concentration ameliorated or masked As toxicity to plant growth and led to higher As concentration in the plant's edible parts. The addition of high soil PO43− concentrations ameliorated or masked As toxicity to plant growth in both individually and As + Sb co-contaminated soil; however, the plant's edible parts accumulated higher As and Sb concentrations. Environ Toxicol Chem 2020;39:1233–1243. © 2020 SETAC
Abstract
A low‐dissipation third‐order weighted essentially nonoscillatory scheme with a new reference smoothness indicator
Authors: Wang Yahui , Du Yulong , Zhao Kunlei , Yuan Li 
Published: March 2020

SummaryThe classical third‐order weighted essentially nonoscillatory (WENO) scheme is notoriously dissipative as it loses the optimal order of accuracy at critical points and its two‐point finite difference in the smoothness indicators is unable to differentiate the critical point from the discontinuity. In recent years, modifications to the smoothness indicators and weights of the classical third‐order WENO scheme have been reported to reduce numerical dissipation. This article presents a new reference smoothness indicator for constructing a low‐dissipation third‐order WENO scheme. The new reference smoothness indicator is a nonlinear combination of the local and global stencil smoothness indicators. The resulting WENO‐Rp3 scheme with the power parameter p=1.5 achieves third‐order accuracy in smooth regions including critical points and has low dissipation, but numerical results show this scheme cannot keep the ENO property near discontinuities. The recommended WENO‐R3 scheme (p=1) keeps the ENO property and performs better than several recently developed third‐order WENO schemes.
Benefits of physical exercise on cognition and glial white matter pathology in a mouse model of vascular cognitive impairment and dementia
Authors: Trigiani Lianne J. , Lacalle‐Aurioles María , Bourourou Miled , Li Lijun , Greenhalgh Andrew D. , Zarruk Juan G. , David Samuel , Fehlings Michael G. , Hamel Edith 
Published: March 2020

AbstractWhite matter (WM) pathology is a clinically predictive feature of vascular cognitive impairment and dementia (VCID). Mice overexpressing transforming growth factor‐β1 (TGF) with an underlying cerebrovascular pathology when fed a high cholesterol diet (HCD) develop cognitive deficits (VCID mice) that we recently found could be prevented by physical exercise (EX). Here, we further investigated cognitive and WM pathology in VCID mice and examined the cellular substrates of the protective effects of moderate aerobic EX focusing on WM alterations. Six groups were studied: Wild‐type (WT) and TGF mice (n = 20–24/group) fed standard lab chow or a 2% HCD, with two HCD‐fed groups given concurrent access to running wheels. HCD had a significant negative effect in TGF mice that was prevented by EX on working and object recognition memory, the latter also altered in WT HCD mice. Whisker‐evoked increases in cerebral blood flow (CBF) were reduced in HCD‐fed mice, deficits that were countered by EX, and baseline WM CBF was similarly affected. VCID mice displayed WM functional deficits characterized by lower compound action potential amplitude not found in EX groups. Moreover, there was an increased number of collapsing capillaries, galectin‐3‐expressing microglial cells, as well as a reduced number of oligodendrocytes in the WM of VCID mice; all of which were prevented by EX. Our findings indicate that a compromised cerebral circulation precedes reduced WM vascularization, enhanced WM inflammation and impaired oligodendrogenesis that all likely account for the increased susceptibility to memory impairments in VCID mice, which can be prevented by EX.
African Head and Neck Society Clinical Practice guidelines for thyroid nodules and cancer in developing countries and limited resource settings
Authors: Zafereo Mark , Yu Justin , Onakoya Paul A. , Aswani Joyce , Baidoo Kenneth , Bogale Mesele , Cairncross Lydia , Cordes Susan , Daniel Adekunle , Diom Evelyne , Maurice Mpessa E. , Mohammed Garba M. , Biadgelign Melesse G. , Koné Fatogoma I. , Itiere Arnaud , Koch Wayne , Konney Anna , Kundiona Innocent , Macharia Chege , Mashamba Victor , Moore Michael G. , Mugabo Rajab M. , Noah Patrick , Omutsani Mary , Orloff Lisa A. , Otiti Jeffrey , Randolph Gregory W. , Sebelik Merry , Todsen Tobias , Twier Khaled , Fagan Johannes J. 
Published: March 2020

AbstractBackgroundInternational thyroid nodule and cancer management guidelines generally fail to take into account potential limitations in diagnostic and treatment resources.MethodsThyroid cancer specialists from the African Head and Neck Society and American Head & Neck Society Endocrine Section developed guidelines for diagnosis and management of thyroid nodules and cancer in low resource settings. Recommendations were based on literature review and expert opinion, with level of evidence defined.ResultsUsing the ADAPTE process, diagnostic and treatment algorithms were adapted from the National Comprehensive Cancer Network (NCCN). Low resource settings were simulated by systematically removing elements such as availability of laboratory testing, hormone replacement, imaging, and cytopathology from NCCN guidelines.ConclusionsSuccessful management of thyroid nodules and cancer in low resource settings requires adaptation of treatment methodologies. These guidelines define specific scenarios where either more or less aggressive intervention for thyroid pathology may be advisable based on limited available resources.
Transcriptional Dynamics of Hepatic Sinusoid‐Associated Cells After Liver Injury
Authors: Terkelsen Mike K. , Bendixen Sofie M. , Hansen Daniel , Scott Emma A.H. , Moeller Andreas F. , Nielsen Ronni , Mandrup Susanne , Schlosser Anders , Andersen Thomas L. , Sorensen Grith L. , Krag Aleksander , Natarajan Kedar N. , Detlefsen Sönke , Dimke Henrik , Ravnskjaer Kim 
Published: March 2020

Background and Aims
Hepatic sinusoidal cells are known actors in the fibrogenic response to injury. Activated hepatic stellate cells (HSCs), liver sinusoidal endothelial cells, and Kupffer cells are responsible for sinusoidal capillarization and perisinusoidal matrix deposition, impairing vascular exchange and heightening the risk of advanced fibrosis. While the overall pathogenesis is well understood, functional relations between cellular transitions during fibrogenesis are only beginning to be resolved. At single‐cell resolution, we here explored the heterogeneity of individual cell types and dissected their transitions and crosstalk during fibrogenesis.

Approach and Results
We applied single‐cell transcriptomics to map the heterogeneity of sinusoid‐associated cells in healthy and injured livers and reconstructed the single‐lineage HSC trajectory from pericyte to myofibroblast. Stratifying each sinusoidal cell population by activation state, we projected shifts in sinusoidal communication upon injury. Weighted gene correlation network analysis of the HSC trajectory led to the identification of core genes whose expression proved highly predictive of advanced fibrosis in patients with nonalcoholic steatohepatitis (NASH). Among the core members of the injury‐repressed gene module, we identified plasmalemma vesicle–associated protein (PLVAP) as a protein amply expressed by mouse and human HSCs. PLVAP expression was suppressed in activated HSCs upon injury and may hence define hitherto unknown roles for HSCs in the regulation of microcirculatory exchange and its breakdown in chronic liver disease.

Conclusions
Our study offers a single‐cell resolved account of drug‐induced injury of the mammalian liver and identifies key genes that may serve important roles in sinusoidal integrity and as markers of advanced fibrosis in human NASH.
Synthetic Conjugates of Ursodeoxycholic Acid Inhibit Cystogenesis in Experimental Models of Polycystic Liver Disease
Authors: Caballero‐Camino Francisco J. , Rivilla Ivan , Herraez Elisa , Briz Oscar , Santos‐Laso Alvaro , Izquierdo‐Sanchez Laura , Lee‐Law Pui Y. , Rodrigues Pedro M. , Munoz‐Garrido Patricia , Jin Sujeong , Peixoto Estanislao , Richard Seth , Gradilone Sergio A. , Perugorria Maria J. , Esteller Manel , Bujanda Luis , Marin Jose J.G. , Banales Jesus M. , Cossío Fernando P. 
Published: March 2020

Background and Aims
Polycystic liver diseases (PLDs) are genetic disorders characterized by progressive development of symptomatic biliary cysts. Current surgical and pharmacological approaches are ineffective, and liver transplantation represents the only curative option. Ursodeoxycholic acid (UDCA) and histone deacetylase 6 inhibitors (HDAC6is) have arisen as promising therapeutic strategies, but with partial benefits.

Approach and Results
Here, we tested an approach based on the design, synthesis, and validation of a family of UDCA synthetic conjugates with selective HDAC6i capacity (UDCA‐HDAC6i). Four UDCA‐HDAC6i conjugates presented selective HDAC6i activity, UDCA‐HDAC6i #1 being the most promising candidate. UDCA orientation within the UDCA‐HDAC6i structure was determinant for HDAC6i activity and selectivity. Treatment of polycystic rats with UDCA‐HDAC6i #1 reduced their hepatomegaly and cystogenesis, increased UDCA concentration, and inhibited HDAC6 activity in liver. In cystic cholangiocytes UDCA‐HDAC6i #1 restored primary cilium length and exhibited potent antiproliferative activity. UDCA‐HDAC6i #1 was actively transported into cells through BA and organic cation transporters.

Conclusions
These UDCA‐HDAC6i conjugates open a therapeutic avenue for PLDs.
Activation of the Liver X Receptor Pathway Inhibits HBV Replication in Primary Human Hepatocytes
Authors: Zeng Jing , Wu Daitze , Hu Hui , Young John A.T. , Yan Zhipeng , Gao Lu 
Published: March 2020

Background and Aims
Hepatitis B virus (HBV) infection is ranked among the top health priorities worldwide. Accumulating evidence suggests that HBV infection and replication are closely associated with liver metabolism. The liver X receptors (LXRs), which belong to the superfamily of nuclear hormone receptors, are important physiological regulators of lipid and cholesterol metabolism. However, the association between the LXR pathway and HBV infection remains largely unclear.

Approach and Results
In this study, the antiviral activity of LXR agonists was investigated using multiple HBV cellular models. We observed that in HBV‐infected primary human hepatocytes (PHHs), synthetic LXR agonists (T0901317, GW3965, and LXR‐623), but not an LXR antagonist (SR9238), potently inhibited HBV replication and gene expression, as demonstrated by substantial reductions in viral RNA, DNA, and antigen production following agonist treatment. However, covalently closed circular DNA (cccDNA) levels were not significantly reduced by the agonists. In addition, no rebound in viral replication was observed after treatment withdrawal, indicating a long‐lasting inhibitory effect. These results suggest that LXR agonists decrease the transcriptional activity of cccDNA. In contrast, no significant anti‐HBV effect was observed in HepG2‐derived cell lines. Interestingly, LXR agonist treatment strongly reduced cholesterol 7α‐hydroxylase 1 (CYP7A1) mRNA levels. Knockdown of CYP7A1 gene expression with small interfering RNA inhibited HBV activity in PHHs, suggesting CYP7A1 as a potential factor contributing to the antiviral effects of LXR agonists.

Conclusions
We found that activation of the LXR pathway with synthetic LXR agonists could elicit potent anti‐HBV activity in PHHs, possibly through sustained suppression of cccDNA transcription. Our work highlights the therapeutic potential of targeting the LXR pathway for the treatment of chronic HBV infection.
Mutations in the V‐ATPase Assembly Factor VMA21 Cause a Congenital Disorder of Glycosylation With Autophagic Liver Disease
Authors: Cannata Serio Magda , Graham Laurie A. , Ashikov Angel , Larsen Lars Elmann , Raymond Kimiyo , Timal Sharita , Le Meur Gwenn , Ryan Margret , Czarnowska Elzbieta , Jansen Jos C. , He Miao , Ficicioglu Can , Pichurin Pavel , Hasadsri Linda , Minassian Berge , Rugierri Alessandra , Kalimo Hannu , Ríos‐Ocampo W. Alfredo , Gilissen Christian , Rodenburg Richard , Jonker Johan W. , Holleboom Adriaan G. , Morava Eva , Veltman Joris A. , Socha Piotr , Stevens Tom H. , Simons Matias , Lefeber Dirk J. 
Published: March 2020

Background and Aims
Vacuolar H+‐ATP complex (V‐ATPase) is a multisubunit protein complex required for acidification of intracellular compartments. At least five different factors are known to be essential for its assembly in the endoplasmic reticulum (ER). Genetic defects in four of these V‐ATPase assembly factors show overlapping clinical features, including steatotic liver disease and mild hypercholesterolemia. An exception is the assembly factor vacuolar ATPase assembly integral membrane protein (VMA21), whose X‐linked mutations lead to autophagic myopathy.

Approach and Results
Here, we report pathogenic variants in VMA21 in male patients with abnormal protein glycosylation that result in mild cholestasis, chronic elevation of aminotransferases, elevation of (low‐density lipoprotein) cholesterol and steatosis in hepatocytes. We also show that the VMA21 variants lead to V‐ATPase misassembly and dysfunction. As a consequence, lysosomal acidification and degradation of phagocytosed materials are impaired, causing lipid droplet (LD) accumulation in autolysosomes. Moreover, VMA21 deficiency triggers ER stress and sequestration of unesterified cholesterol in lysosomes, thereby activating the sterol response element‐binding protein–mediated cholesterol synthesis pathways.

Conclusions
Together, our data suggest that impaired lipophagy, ER stress, and increased cholesterol synthesis lead to LD accumulation and hepatic steatosis. V‐ATPase assembly defects are thus a form of hereditary liver disease with implications for the pathogenesis of nonalcoholic fatty liver disease.
Data or interpretations: Impacts of information presentation strategies on diagnostic processes
Authors: Müller Romy , Gögel Christina , Bönsel Rica 
Published: March 2020

AbstractIndustrial fault diagnosis can be supported by assistance systems that infer fault causes from sensor data. The present study asked what information these algorithms should make available to operators. In a computer‐based experiment about fault diagnosis in a packaging machine, three information presentation strategies were compared regarding their impacts on information sampling, performance, and knowledge acquisition: Providing only sensor data, sensor data along with three possible interpretations, or only the most likely interpretation. Before submitting a diagnosis, participants could sample process parameters, one of which indicated the fault cause. We hypothesized that providing only sensor data would lead to more parameter checking and slower solutions than interpretations. While providing only one interpretation was expected to enable efficient performance for correct interpretations, it should lead to either of two types of performance costs for incorrect interpretations: Errors if participants refrain from checking parameters, or slowdowns in performance if they keep on checking. The results confirmed that participants with only sensor data performed inefficiently. Participants with only one interpretation thoroughly checked parameters but still were fastest when the interpretation was correct, while when it was incorrect they were three times slower than participants with only sensor data. Participants with three interpretations (one of which was always correct) performed almost as efficiently as those with only one correct interpretation. The results indicate that highly preprocessed information leads to efficient performance when it is correct but prevents learning about fault causes. Overall, providing several possible interpretations seemed to be the best strategy.
Perceived trust in artificial intelligence technologies: A preliminary study
Authors: Bitkina Olga Vl. , Jeong Heejin , Lee Byung Cheol , Park Jangwoon , Park Jaehyun , Kim Hyun K. 
Published: March 2020

AbstractArtificial intelligence (AI) is becoming increasingly prevalent in all spheres of society. Still, the perception of AI from users and customers remains the main barrier for its widespread adoption. Previous studies showed that the acceptance of new technologies in society depends on perceived characteristics. This study examined users’ perception of trust, the difficulty of the task, and application performance when using an AI‐based technology. These factors help us to elucidate the mechanisms for building trust in AI technology from the users’ perspective. A total of 18 participants took part in the experiment with the Google AutoDraw software as an AI tool. As a result, the difficulty of the task, perceived performance, and success/failure of the task can be regarded as the influential factors for the perceived trust evaluation. The perceived trust of users in new AI products would be increased by improving product performance and the successful implementation of the tasks. The obtained results and insights can serve AI product developers to increase the level of users’ trust and attraction towards their technologies and applications.