bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex Differences in Long‐Term Outcomes in Patients With Deferred Revascularization Following Fractional Flow Reserve Assessment: International Collaboration Registry of Comprehensive Physiologic Evaluation
Authors: Hoshino Masahiro , Hamaya Rikuta , Kanaji Yoshihisa , Kanno Yoshinori , Hada Masahiro , Yamaguchi Masao , Sumino Yohei , Hirano Hidenori , Horie Tomoki , Usui Eisuke , Sugiyama Tomoyo , Murai Tadashi , Lee Tetsumin , Yonetsu Taishi , Lee Joo Myung , Choi Ki Hong , Hwang Doyeon , Park Jonghanne , Jung Ji‐Hyun , Kim Hyung Yoon , Jung Hae Won , Cho Yun‐Kyeong , Yoon Hyuck‐Jun , Song Young Bin , Hahn Joo‐Yong , Doh Joon‐Hyung , Nam Chang‐Wook , Shin Eun‐Seok , Hur Seung‐Ho , Mejía‐Rentería Hernán , Lauri Francesco , Goto Sonoka , Macaya Fernando , McInerney Angela , Gravina Giacomo , Vera Rafael , Gonzalo Nieves , Jimenez‐Quevedo Pilar , Nuñez‐Gil Ivan , Salinas Pablo , Nombela‐Franco Luis , del Trigo Maria , Fernández‐Ortiz Antonio , Macaya Carlos , Koo Bon‐Kwon , Escaned Javier , Kakuta Tsunekazu 
Published: February 2020

Background

Sex‐specific differences may influence prognosis after deferred revascularization following fractional flow reserve (
FFR
) measurement. This study sought to investigate the sex differences in long‐term prognosis of patients with deferred revascularization following
FFR
assessment.

Methods and Results

A total of 879 patients (879 vessels) with deferred revascularization with
FFR
>0.75 who underwent
FFR
and coronary flow reserve measurements were enrolled from 3 countries (Korea, Japan, and Spain). Long‐term outcomes were assessed in 649 men and 230 women by the patient‐oriented composite outcome (
POCO
, a composite of any death, any myocardial infarction, and any revascularization). We applied inverse‐probability weighting based on propensity scores to account for differences at baseline between women and men (age, hyperlipidemia, diabetes mellitus, diameter stenosis, lesion length, multivessel disease,
FFR
, coronary flow reserve. The median follow‐up duration was 1855 days (745–1855 days). Median
FFR
values were 0.88 (0.83–0.93) in men and 0.89 (0.85–0.94) in women, respectively. The occurrences of
POCO
were significantly high in men compared with that in women (10.5% versus 4.2%,
P
=0.007). Kaplan–Meier analysis revealed that women had a significantly lower risk of
POCO
(χ
2
=7.2,
P
=0.007). Multivariate
COX
proportional hazards regression analysis revealed that age, male, diabetes mellitus, diameter stenosis, lesion length, and coronary flow reserve were independent predictors of
POCO
. After applying
IPW
, the hazard ratio of males for
POCO
was 2.07 (95% CI, 1.07–4.04,
P
=0.032).

Conclusions

This large multinational study reveals that long‐term outcome differs between women and men in favor of women after
FFR
‐guided revascularization deferral.

Clinical Trial Registration

URL
:
http://www.ClinicalTrials.gov
. Unique identifier:
NCT
02186093.
Measures of Poor Sleep Quality Are Associated With Higher Energy Intake and Poor Diet Quality in a Diverse Sample of Women From the Go Red for Women Strategically Focused Research Network
Authors: Zuraikat Faris M. , Makarem Nour , Liao Ming , St‐Onge Marie‐Pierre , Aggarwal Brooke 
Published: February 2020

Background
Poor sleep increases cardiovascular disease risk, and diet likely contributes to this relationship. However, there are limited epidemiological data on the relationship between measures of sleep quality and habitual dietary patterns. This study examined these associations in a diverse sample of women.

Methods and Results

Baseline data from 495 participants in the
AHA
Go Red for Women prospective cohort study (age: 20–76 years; 61% racial/ethnic minority) were examined. Sleep quality and sleep‐onset latency were measured using the Pittsburgh Sleep Quality Index (
PSQI
) and insomnia using the Insomnia Severity Index. The validated Block Brief Food Frequency Questionnaire was used to assess diet quantity and quality. Linear regression models adjusted for confounding variables tested relationships between sleep and diet variables. Results showed that higher
PSQI
scores, indicative of poorer sleep quality, were associated with lower unsaturated fat intake (β=−0.14,
P
<0.05) and higher food weight (β=14.9,
P
=0.02) and added sugars consumed (β=0.44,
P
=0.04). Women with sleep‐onset latency >60 minutes had higher intakes of food by weight (β=235.2,
P<
0.01) and energy (β=426,
P
<0.01), and lower intakes of whole grains (β=−0.37,
P
=0.01) than women with sleep‐onset latency ≤15 minutes. Greater insomnia severity was associated with higher food weight (β=9.4,
P
=0.02) and energy (β=17,
P
=0.01) consumed and lower total (β=−0.15,
P
=0.01) and unsaturated fat intakes (β=−0.11,
P
<0.01).

Conclusions
Poor sleep quality was associated with greater food intake and lower‐quality diet, which can increase cardiovascular disease risk. Future studies should test whether promoting sleep quality could augment efforts to improve cardiometabolic health in women.
Sex‐Specific Associations of Vascular Risk Factors With Abdominal Aortic Aneurysm: Findings From 1.5 Million Women and 0.8 Million Men in the United States and United Kingdom
Authors: Carter Jennifer L. , Morris Dylan R. , Sherliker Paul , Clack Rachel , Lam Kin Bong Hubert , Halliday Alison , Clarke Robert , Lewington Sarah , Bulbulia Richard 
Published: February 2020

Background

Large studies are required for reliable estimates of important risk factors for abdominal aortic aneurysm (
AAA
). This could guide targeted
AAA
screening programs, particularly in subgroups like women who are currently excluded from such programs.

Method and Results

In a cross‐sectional study, 1.5 million women and 0.8 million men without known vascular disease attended commercial screening clinics in the United Kingdom or United States from 2008 to 2013. Measurements of vascular risk factors were related to
AAA
using logistic regression with correction for regression dilution bias. Screening detected 12 729 new
AAA
cases (0.6%). Compared with never smoking, current smoking was associated with 15 times the risk of
AAA
among women (risk ratio 15.0, 95%
CI
13.2–17.0) and 7 times among men (7.3, 6.4–8.2). In women aged <75 years, the risk of
AAA
was nearly 30 times greater in current smokers (26.4, 20.3–34.2). In every age group, the prevalence of
AAA
in female smokers was greater than in male never‐smokers. Positive log‐linear associations with
AAA
for women and men were also observed for usual body mass index, usual systolic blood pressure, height, usual low‐density lipoprotein cholesterol, and usual triglycerides.

Conclusions

Log‐linear increases in the risks of
AAA
with traditional vascular risk factors should be considered when evaluating populations that may be at‐risk for the development of
AAA
, and when considering potential treatments. However, at any given age, female smokers are at higher risk of
AAA
than male never‐smokers, and a policy of screening male never‐smokers but not higher‐risk female smokers is questionable.
Exploring the Usefulness of Meteorological Data for Predicting Malaria Cases in Visakhapatnam, Andhra Pradesh
Authors: Sehgal Meena , Ghosh Sujit 
Published: February 2020

AbstractMalaria and dengue fever are among the most important vectorborne diseases in the tropics and subtropics. Average weekly meteorological parameters—specifically, minimum temperature, maximum temperature, humidity, and rainfall—were collected using data from 100 automated weather stations from the Indian Space Research Organization. We obtained district-level weekly reported malaria cases from the Integrated Disease Surveillance Program (IDSP), Department of Health and Family Welfare, Andhra Pradesh, India, for three years, 2014–16. We used a generalized linear model with Poisson distribution and default logarithm-link to estimate model parameters, and we used a quasi-Poisson method with a generalized additive model that uses nonparametric regression with smoothing splines. It appears that higher minimum temperatures (e.g., >24°C) tend to lead to higher malaria counts but lower values do not seem to have an impact on the malaria counts. On the other hand, higher values of maximum temperature (e.g., >32°C) seem to negatively affect the malaria counts. The relationships with rainfall and humidity appear to be not as strong once we account for smooth (weekly) trends and temperatures; both smooth curves seem to hover around zero across all of their values. We note that a rainfall amount between 40 and 50 mm seems to have a positive impact on malaria counts. Our analyses show that the incremental increase in meteorological parameters does not lead to an increase in reported malaria cases in the same manner for all of the districts within the same state. This suggests that other factors such as vegetation, elevation, and water index in the environment also influence disease occurrence.
The effect of Sports-based Physical Activity programme on teachers’ relatedness, stress and exercise motivation
Authors: Kim Gi-cheol , Gurvitch Rachel 
Published: February 2020

Background: Teacher wellness affects teaching performance and students’ academic achievement; hence, teacher wellness matters and should be a concern to educational researchers and practitioners. There are several teacher wellness approaches, but no one of them specifically focuses on a Sports-based Physical Activity programme. Objective: To evaluate the effects of a Sports-based Physical Activity programme on teachers’ relatedness, stress and motivation towards physical activity. Method: Middle school teachers ( n = 32) volunteered to participate in the research as programme participants ( n = 12) or non-programme participants ( n = 20). The Sports-based Physical Activity programme included 7 weeks of training in Catchball, a team sport and a tournament as the culminating event. The study adopted a mixed-methods design: a quasi-experimental design collecting quantitative data from online surveys and a case study design collecting qualitative data from interviews with the programme participants, non-participants and the school principal. Results: Repeated-measures analysis of variance revealed that the Sports-based Physical Activity programme was effective in relatedness, F(1, 30) = 5.16, p = .031, [Formula: see text] = .147, and in one of the six motivation subscales, external regulation, F(1, 30) = 4.23, p = .048, [Formula: see text] = .124. The qualitative analysis findings supported the programme’s contribution to teachers’ relationship, stress and exercise motivation. Conclusion: Overall, the programme was effective in promoting teachers’ relationships in school, controlling levels of teachers’ stress and fostering teachers’ motivation towards physical activity. Further studies are required to examine the impact of a Sports-based Physical Activity approach in diverse school contexts and its impact on student learning.
Does axillary lymph node size predict better metastatic involvement than apparent diffusion coefficient (ADC) value in women with newly diagnosed breast cancer?
Authors: Ramírez-Galván Yazmín Aseret , Cardona-Huerta Servando , Elizondo-Riojas Guillermo , Álvarez-Villalobos Neri Alejandro , Campos-Coy Mario Alberto , Ferrara-Chapa Carla Melissa 
Published: February 2020

Background It has been demonstrated that the number of metastatic axillary lymph nodes (mALNs) influence disease-free and overall survival in patients with breast cancer. Purpose To determine if the ALN size is more accurate than the ALN apparent diffusion coefficient (ADC) value to predict metastatic involvement in newly diagnosed breast cancer. Material and Methods A total of 44 patients with breast cancer were included. Magnetic resonance imaging (MRI) examinations were performed on a 1.5-T system with sagittal T1-weighted fast spin-echo non-fat saturated, sagittal T2-weighted fast spin-echo non-fat saturated, axial diffusion-weighted imaging echo-planar (b values of 0 and 700 s/mm2), and non-contrast axial VIBRANT sequences. The size and the ADC value were obtained for ALN ipsilateral and contralateral to breast cancer. The reference standard was the histopathologic lymph node status. Results mALN had a greater cortical thickness compared to contralateral non-mALN (10.3 ± 5.32 mm vs. 4 ± 1.17 mm, P ≤ 0.001). The threshold of ≥6.7 mm for predicting axillary metastatic involvement had a sensitivity and a specificity of 80.0% and 97.7%, respectively. The ADC value of mALN was significantly higher than the contralateral non-mALN (0.90 ± 0.12 × 10−3mm2/s vs. 0.78 ± 0.12 × 10−3mm2/s; P = 0.001). The threshold of ≥0.86 × 10−3mm2/s had a sensitivity and a specificity of 66.7% and 76.7%, respectively. Conclusion Our results indicate that the cortical thickness has a better diagnostic performance in the differentiation of metastatic and non-metastatic lymph nodes than the lymph node ADC.
Radiogenomic Models Using Machine Learning Techniques to Predict EGFR Mutations in Non-Small Cell Lung Cancer
Authors: Nair Jay Kumar Raghavan , Saeed Umar Abid , McDougall Connor C. , Sabri Ali , Kovacina Bojan , Raidu B. V. S. , Khokhar Riaz Ahmed , Probst Stephan , Hirsh Vera , Chankowsky Jeffrey , Van Kempen Léon C. , Taylor Jana 
Published: February 2020

Background: The purpose of this study was to build radiogenomics models from texture signatures derived from computed tomography (CT) and 18F-FDG PET-CT (FDG PET-CT) images of non-small cell lung cancer (NSCLC) with and without epidermal growth factor receptor ( EGFR) mutations. Methods: Fifty patients diagnosed with NSCLC between 2011 and 2015 and with known EGFR mutation status were retrospectively identified. Texture features extracted from pretreatment CT and FDG PET-CT images by manual contouring of the primary tumor were used to develop multivariate logistic regression (LR) models to predict EGFR mutations in exon 19 and exon 20. Results: An LR model evaluating FDG PET-texture features was able to differentiate EGFR mutant from wild type with an area under the curve (AUC), sensitivity, specificity, and accuracy of 0.87, 0.76, 0.66, and 0.71, respectively. The model derived from CT texture features had an AUC, sensitivity, specificity, and accuracy of 0.83, 0.84, 0.73, and 0.78, respectively. FDG PET-texture features that could discriminate between mutations in EGFR exon 19 and 21 demonstrated AUC, sensitivity, specificity, and accuracy of 0.86, 0.84, 0.73, and 0.78, respectively. Based on CT texture features, the AUC, sensitivity, specificity, and accuracy were 0.75, 0.81, 0.69, and 0.75, respectively. Conclusion: Non-small cell lung cancer texture analysis using FGD-PET and CT images can identify tumors with mutations in EGFR. Imaging signatures could be valuable for pretreatment assessment and prognosis in precision therapy.
The Acquisition of 21st-Century Skills Through Video Games: Minecraft Design Process Models and Their Web of Class Roles
Authors: Hewett Katherine J. E. , Zeng Guang , Pletcher Bethanie C. 
Published: February 2020

Background. Qian and Clark reported that little is known on the acquisition of 21st-century skills through video games and no educational model exists on how to best teach these skills in the classroom. Studies that explore educational models exhibited through video games like Minecraft contribute to the growing body of research in the field of game studies, game-based learning, and virtual environments. Aim. The purpose of this qualitative case study was to explore the 21st-century design processes, skills, and behaviors of high school gamers in order to generate an educational model that illustrates how those classroom gamers attempted to critically think, create, communicate, and collaborate (Four Cs) in Minecraft. Method. The triangulated data collection included six qualitative case study interviews, observation data (with demographics) from thirteen participants, and visual artifacts from six classes grounded in social constructivist, social constructionist, and interpretivist theories. It should be noted that ninety-five students collaborated with the participants on the six Minecraft projects. Results. The data collection generated two educational Four Cs models that illustrate the participants’ leadership and design processes. Four 21st-century themes emerged from the research study: 1.) Leadership: Models for Design 2.) Navigating the 3D World, 3.) Think Outside-the-Box, and 4.) Real-world Connections. Conclusions. It can be concluded that Minecraft can help students learn to problem-solve, improve their research skills, be resourceful, multitask, and develop their social skills through teamwork (Four Cs). When students are given a task in Minecraft they will self-organize and student leaders will emerge. Minecraft challenged the participants to assess a problem, analyze it from another perspective, and find a creative solution collaboratively.
Oral-Facial-Digital Syndrome Type 1: Further Clinical and Molecular Delineation in 2 New Families
Authors: Faily Sara , Perveen Rahat , Chandler Kate , Clayton-Smith Jill 
Published: February 2020

Objective:Oral-facial-digital syndrome type 1 (OFD1) [OMIM 311200] is a rare genetic disorder associated with congenital anomalies of the oral cavity, face, and digits. This condition is associated with mutations in the OFD1 gene. Our objective was to recruit patients with the OFD1 clinical phenotype without genetic confirmation, aiming to identify genetic variants in the OFD1 gene.Design:Three patients from 2 unrelated families were recruited into our study. We employed a variety of genomic techniques on these patients, including candidate gene analysis, array comparative genomic hybridization, whole-exome sequencing, and whole-genome sequencing.Results:We investigated 3 affected patients from 2 unrelated families with a clinical diagnosis of OFD1. We discovered a novel pathogenic dominant missense mutation c.635G>C (p.Arg212Pro) in the OFD1 gene in one family. A novel frameshift, loss-of-function mutation c.306delA (p.Glu103LysfsTer42) was detected in the affected patient in the second family.Conclusions:These new genetic variants will add to the spectrum of known OFD1 mutations associated with the OFD1 disorder. Our study also confirms the variable phenotypic presentation of OFD1 and its well-recognized association with central nervous system malformations and renal anomalies. Molecular diagnostic confirmation achieved in these families will have positive implications for their medical management.
Synchronous duodenum and descending colon metastasis from primary lung neuroendocrine small-cell carcinoma: A case report and review of the literature
Authors: Tanriverdi Ozgur , Alkan Ali , Ozseker Burak , Solak-Ozseker Havva , Kilinc Rabia Mihriban 
Published: February 2020

Introduction Metastasis to the gastrointestinal tract from lung cancer is very uncommon and is often asymptomatic. Although small bowel metastasis may commonly occur, metastases to the stomach and colon are uncommon. Case report In this paper, we present a previously healthy 57-year-old male patient, a 60-packet per year smoker, who was taken to the emergency room with complaints of increasing abdominal pain, rectal bleeding, weight loss, and dyspnea for the last three months. Endoscopic examination revealed polypoid lesions in the duodenum and the descending colon. We diagnosed neuroendocrine small-cell lung cancer based on histopathological and immunohistochemical staining. Management and outcome: A cisplatin (d1, 60 mg/m2/day)–etoposide (d1 to d3, 120 mg/m2/day) regimen was given every three weeks as palliative chemotherapy. After the three course of chemotherapy, the lung radiograph showed a decline in hilar expansion and there was no pleural effusion. Then, he died of acute respiratory failure two weeks after radiotherapy of brain. Discussion Gastrointestinal tract metastasis of lung cancer is recognized synchronously with or rarely before diagnosis. It is generally recognized after the diagnosis of lung cancer. These patients often have other concurrent body metastases. Prognosis is poor, and survival expectation is short. The most common metastases to the gastrointestinal tract are squamous and large cell lung cancer metastases. Our aim is to emphasize the importance of immunohistochemical examination for masses in the gastrointestinal tract and to present this rare case of synchronous duodenal and colonic metastases of small-cell lung cancer.
The real-life outcome of pazopanib in patients with advanced soft tissue sarcoma: A retrospective cross-sectional study of a Turkish cohort
Authors: Karaağaç Mustafa , Sezgin Yasin , Eryılmaz Melek Karakurt , Araz Murat , Kaplan Muhammet Ali , Artaç Mehmet 
Published: February 2020

Introduction Soft tissue sarcomas are a heterogeneous and rare group of cancers with a short median overall survival despite the chemotherapy. Pazopanib has approval for the treatment of advanced soft tissue sarcoma. We aimed to investigate the clinical outcomes of Turkish patients with advanced soft tissue sarcoma who received pazopanib. Patients and methods This was a retrospective study. The inclusion criteria were: ≥18 years of age, having histologically proven advanced soft tissue sarcoma and receiving pazopanib at least one day. Results A total of 79 patients were assessed in this study. The median age was 49.6 years. The average dose intensity of pazopanib was 767 mg (400–800). The median duration of pazopanib treatment was 6.11 months. Fourteen patients (17.7%) used pazopanib at first line for advanced soft tissue sarcomas. The most common cause of discontinuation of pazopanib was the progression of the disease (89.6%). Pazopanib was well tolerated. The most common grade ≥3 side effect was anemia. The most common grade ≤2 side effects were anemia and hyperbilirubinemia. The median progression-free survival, overall survival, and follow-up were 3.97 months, 11.40 months, and 32.72 months, respectively. Female gender, good performance status, and the presence of pazopanib-induced hypothyroidism were associated with longer progression-free survival. Also, good performance status and being a responder to first-line treatment were associated with longer overall survival. Conclusions We showed that pazopanib was well tolerated and had clinical benefit in patients with advanced soft tissue sarcoma in a Turkish cohort. This is the first study that suggests pazopanib-induced hypothyroidism may act as a predictive marker for better outcomes in patients with advanced soft tissue sarcoma.