bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of taichi on grade 1 hypertension: A study protocol for a randomized controlled trial
Authors: Lee Sang-Hyun , Kim Byung-Jun , Park In-Hwa , Hwang Eui-Hyoung , Park Eun Ju , Jang Insoo , Hwang Man-Suk 
Published: February 2020

Abstract
Background
Medication is generally recommended to reduce the morbidity and mortality caused by cardiovascular disease in hypertensive patients. However, considering the difficulties and economic factors associated with long-term medication, interest in taichi as an exercise treatment method has increased recently in Korean medical practice. Numerous studies have suggested that taichi can be used to treat various diseases and that is can affect psychosomatic factors such as anxiety. This study aims to evaluate the effect of taichi in reducing blood pressure among grade 1 hypertensive patients.

Methods/design
In this randomized, active-controlled, assessor-blinded, two parallel-armed trial, 80 grade 1 hypertension patients will be recruited and randomly assigned to the usual care group or to the taichi group (n = 40 in each group). Subjects who voluntarily sign a study agreement will be educated in managing their own blood pressure by restricting salt intake, losing weight, moderating alcohol consumption, performing exercise, and regulating dietary intake at their first visit. In addition to self-management, the taichi group will perform two 60-min taichi sessions per week for a total of 8 weeks. Blood pressure will be measured as the primary outcome. In addition, body composition, heart rate, and the perceived intensity and difficulty of the exercise will be measured as secondary outcomes.

Discussion
This study is a randomized controlled trial of taichi, which is not widely practiced in Korea. It may provide valuable data on the effects of taichi on hypertension, which will inform non-pharmaceutical treatment options for this disorder.

Trial registration
Clinical Research Information Service, KCT0003632. Registered on 18 March 2019.
Pharmacokinetics, SAfety/tolerability, and EFficacy of high-dose RIFampicin in tuberculosis-HIV co-infected patients on efavirenz- or dolutegravir-based antiretroviral therapy: study protocol for an open-label, phase II clinical trial (SAEFRIF)
Authors: Nabisere Ruth , Musaazi Joseph , Denti Paolo , Aber Florence , Lamorde Mohammed , Dooley Kelly E. , Aarnoutse Rob , Sloan Derek J. , Sekaggya-Wiltshire Christine 
Published: February 2020

AbstractBackgroundTuberculosis (TB) is a significant public health problem that causes substantial morbidity and mortality. Current first-line anti-TB chemotherapy, although very effective, has limitations including long-treatment duration with a possibility of non-adherence, drug interactions, and toxicities. Dose escalation of rifampicin, an important drug within the regimen, has been proposed as a potential route to higher treatment efficacy with shorter duration and some studies have suggested that dose escalation is safe; however, these have almost entirely been conducted among human immunodeficiency (HIV)-negative TB patients. TB-HIV co-infected patients on antiretroviral therapy (ART) are at increased risk of drug-drug interactions and drug-related toxicities. This study aims to determine the safety of higher doses of rifampicin and its effect on the pharmacokinetics of efavirenz (EFV) and dolutegravir (DTG) in TB-HIV co-infected patients.MethodsThis study is a randomized, open-label, phase IIb clinical trial among TB-HIV infected adult outpatients attending an HIV clinic in Kampala, Uganda. Patients newly diagnosed with TB will be randomized to either standard-dose or high-dose rifampicin (35 mg/kg) alongside standard TB treatment. ART-naïve patients will be randomly assigned to first-line ART regimens (DTG or EFV). Those who are already on ART (DTG or EFV) at enrollment will be continued on the same ART regimen but with dose adjustment of DTG to twice daily dosing. Participants will be followed every 2 weeks with assessment for toxicities at each visit and measurement of drug concentrations at week 6. At the end of intensive-phase therapy (8 weeks), all participants will be initiated on continuation-phase treatment using standard-dose rifampicin and isoniazid.DiscussionThis study should avail us with evidence about the effect of higher doses of rifampicin on the pharmacokinetics of EFV and DTG among TB-HIV co-infected patients. The trial should also help us to understand safety concerns of high-dose rifampicin among this vulnerable cohort.Trial registrationClinicalTrials.gov, ID:NCT03982277. Registered retrospectively on 11 June 2019.
Atrial myxoma with cerebellar signs: a case report
Authors: Shrestha Suraj , Raut Akash , Jayswal Amar , Yadav Randhir Sagar , Poudel Chandra Mani 
Published: February 2020

Abstract
Background
Atrial myxoma remains a rare clinical entity with an incidence of surgically resected cases of 0.5–0.7 per million population and prevalence of < 5 per 10,000. It typically manifests in woman after third decade of life; symptoms vary greatly and may present with arrhythmia, intracardiac flow obstruction, embolic phenomenon, and associated constitutional symptoms. Neurological complications associated with atrial myxoma most frequently include cerebral infarct due to embolus. Cerebellar involvement is very rare and only a few cases have been reported in the literature.

Case presentation
A 55-year-old Brahmin man with no history of diabetes mellitus and hypertension, presented with complaints of dizziness, headache, vomiting, double vision, and unsteadiness of gait for 2 weeks. His headache was sudden in onset, of a pulsating type and localized on left temporal side. Vomiting was projectile and bilious. Double vision was present in all directions of gaze and he had uncoordinated movement of his body and tilting to the left side. On examination, his cerebellar functions were impaired. He was thoroughly investigated for the cause of stroke after abnormal magnetic resonance imaging results with normal computed tomography angiography of his brain. Echocardiography and computed tomography of his chest showed a mass attached to intra-atrial septum and prolapsing through mitral valve, which was suggestive of left atrial myxoma. Five days following admission, he developed abdominal pain due to thromboembolism causing splenic and renal infarct.

Conclusion
Although rare, atrial myxoma has to be considered a cause of stroke and other embolic phenomenon causing multiorgan infarctions. Early and timely diagnosis of the condition can prevent further recurrence and inappropriate anticoagulant therapy. It would be pertinent to have echocardiography done in patients who present with a stroke, arrhythmias, and other constitutional symptoms. The tumor once detected must be removed surgically as early as possible, which not only reduces serious thromboembolic complications but can be potentially curative.
Metabolite profiles of live or dead carp (Cyprinus carpio) exposed to endosulfan sulfate using a targeted GC–MS analysis
Authors: Lee Hwa-Kyung , Lee Junghak , Lee Jonghwa , Lee Hyeri , Kim Jeong-Han 
Published: February 2020

AbstractEndosulfan sulfate is a major oxidized metabolite of endosulfan, which is a broad-spectrum chlorinated cyclodiene insecticide. In this study, GC–MS-based metabolic profiles of dead or live carp (Cyprinus carpio) exposed to endosulfan sulfate were investigated to elucidate the molecular toxicological effects of endosulfan sulfate on carp. Three different extraction methods were compared, and a 50% methanol solution was chosen as an efficient extraction method. Carp was exposed to endosulfan sulfate at a concentration of 8 ppb for 2 days. After exposure, the whole body of the fish was homogenized with liquid N2, extracted with the 50% methanol solution and dried before TMS derivatization for GC–MS analyses of the dead and live carp. A SIM (selected ion monitoring)-library of 373 metabolites was applied after GC–MS analysis to detect 146 metabolites in carp. Based on the one-way ANOVA results (P < 0.001) and fold changes of metabolites in dead carp versus control (fold change > 1.5 or < 0.667), 30 metabolites were identified as biomarkers that were significantly different in the metabolic profiles among the control, dead and live carp. A metabolic pathway analysis using MetaboAnalyst 4.0 revealed that those biomarkers were important for the living or death response to endosulfan sulfate. The pathways indicated by the metabolic pathway analysis included starch and sucrose metabolism, galactose metabolism, glycerolipid metabolism, the citrate cycle and linoleic acid metabolism. These results suggest that these pathways underwent significant perturbations over the exposure period.
Impact of resettlement scheme on vegetation cover and its implications on conservation in Chewaka district of Ethiopia
Authors: Abera Alemayehu , Yirgu Teshome , Uncha Abera 
Published: February 2020

Abstract
Background
Resettlement has been conceived as a viable solution to the continual impoverishment and destitution of Ethiopian rural communities. However, it has considerable impacts on natural resources of the environment at destination areas. This study was carried out to evaluate impact of resettlement scheme on vegetation cover and its implications on conservation in Chewaka district of Ethiopia.

Methods
The study utilized ArcGIS10.3, ERDAS Imagine 9.1, Landsat imageries of 2000, 2009, 2018 and socio-economic data to analyze the LULC of the district. Normalized Difference Vegetation Index was employed to detect vegetation cover changes of the area. The study was conducted on the seven kebeles of Chewaka district and the total households of the sample kebeles are 3340. Through multistage sampling procedure a total of 384 households were selected from sample kebeles. Data were collected using questionnaires, GPS, interviews, focus group discussions and field observations. The collected data were analyzed both quantitatively and qualitatively.

Results
The results showed that Chewaka district has undergone substantial LULC change since population resettlement in the area. A rapid reduction of woodland (34.6%), forest (59.9%), grassland (50.5%) and bareland (46.8%) took place between 2000 and 2018, while built-up areas and cultivated lands have expanded at an average rate of 90.7 and 1515.7 ha/year respectively. The results of NDVI revealed that the extent of dense and sparse vegetation cover have decreased by 26.1% and 20.6% respectively, whereas non-vegetation cover has increased by 14,340.2 ha during the study period. It was found that rapid population growth following resettlement program, farmland and settlement expansion, deforestation, human-induced forest fire, lack of land use plan, unwise utilization and low management practices were the major factors that underpin the observed changes in the area.

Conclusions
Resettlement scheme has resulted in the depletion and dynamics of vegetation cover in Chewaka district. Therefore, the study suggests urgent attention on conservation of the remaining vegetation resources for sustainable utilization.
Using toponomics to characterize phenotypic diversity in alveolar macrophages from male mice treated with exogenous SP-A1
Authors: Phelps David S. , Chinchilli Vernon M. , Weisz Judith , Shearer Debra , Zhang Xuesheng , Floros Joanna 
Published: February 2020

AbstractBackgroundWe used the Toponome Imaging System (TIS) to identify “patterns of marker expression”, referred to here as combinatorial molecular phenotypes (CMPs) in alveolar macrophages (AM) in response to the innate immune molecule, SP-A1.MethodsWe compared 114 AM from male SP-A deficient mice. One group (n = 3) was treated with exogenous human surfactant protein A1 (hSP-A1) and the other with vehicle (n = 3). AM obtained by bronchoalveolar lavage were plated onto slides and analyzed using TIS to study the AM toponome, the spatial network of proteins within intact cells. With TIS, each slide is sequentially immunostained with multiple FITC-conjugated antibodies. Images are analyzed pixel-by-pixel identifying all of the proteins within each pixel, which are then designated as CMPs. CMPs represent organized protein clusters postulated to contribute to specific functions.Results1) We compared identical CMPs in KO and SP-A1 cells and found them to differ significantly (p = 0.0007). Similarities between pairs of markers in the two populations also differed significantly (p < 0.0001). 2) Focusing on the 20 most abundant CMPs for each cell, we developed a method to generate CMP “signatures” that characterized various groups of cells. Phenotypes were defined as cells exhibiting similar signatures of CMPs. i) AM were extremely diverse and each group contained cells with multiple phenotypes. ii) Among the 114 AM analyzed, no two cells were identical. iii) However, CMP signatures could distinguish among cell subpopulations within and between groups. iv) Some cell populations were enriched with SP-A1 treatment, some were more common without SP-A1, and some seemed not to be influenced by the presence of SP-A1. v) We also found that AM were more diverse in mice treated with SP-A1 compared to those treated with vehicle.ConclusionsAM diversity is far more extensive than originally thought. The increased diversity of SP-A1-treated mice points to the possibility that SP-A1 enhances or activates several pathways in the AM to better prepare it for its innate immune functions and other functions shown previously to be affected by SP-A treatment. Future studies may identify key protein(s) responsible for CMP integrity and consequently for a given function, and target it for therapeutic purposes.
Increased PD-1+Tim-3+ exhausted T cells in bone marrow may influence the clinical outcome of patients with AML
Authors: Tan Jiaxiong , Yu Zhi , Huang Jingying , Chen Youchun , Huang Shuxin , Yao Danlin , Xu Ling , Lu Yuhong , Chen Shaohua , Li Yangqiu 
Published: February 2020

Abstract
Background
Altered expression of T cell immune inhibitory receptors may result in immunosuppression and associate with the poor prognosis of leukemia patients in which the leukemic bone marrow (BM) microenvironment may contribute to such immunosuppression. We found higher numbers of programmed death-1 (PD-1) + exhausted T cells in peripheral blood (PB) from acute myeloid leukemia (AML) patients. To investigate the leukemic BM influence on immunosuppression, we further compared the distributions of PD-1 and T cell immunoglobulin mucin-3 (Tim-3) and the exhausted T cell phenotype in PB and BM from AML patients and characterized their relationship with clinical outcome.

Methods
PB and BM samples from 15 patients with newly diagnosed AML were collected and analyzed for the expression of PD-1, Tim-3, CD244, and CD57 on CD3+, CD4+, and CD8+ T cells by multicolor flow cytometry.

Results
The proportions of PD-1 + CD3+ and PD-1 + CD8+ T cells were significantly higher in BM compared with PB. Similarly, higher PD-1 + CD244 + CD3+ and PD-1 + CD244 + CD8+ T cells were found in BM, and an increased tendency for PD-1 + CD244 + CD4+ T cells was also detected in this group. In contrast, increased Tim-3 + CD4+/Tim-3 + CD244 + CD4+ T cells were predominant in BM compared with PB, but there was no statistically significant difference in Tim-3 + CD8+ T cells. Moreover, PD-1 and Tim-3 double-positive CD3+/CD4+/CD8+ T cells were significantly increased in the BM group. In addition, a higher proportion of PD-1 + Tim-3 + CD3+ T cells in the BM and PD-1 + Tim-3 + CD4+ T cells in PB was detected in non-complete remission (NCR) compared with complete remission (CR) patients after first-cycle chemotherapy.

Conclusions
Upregulation of PD-1 and Tim-3 and the exhausted phenotype of CD4+ and CD8+ T cells in the BM of AML patients may contribute to mediating the leukemic immunosuppressive microenvironment, and increased PD-1 + Tim-3+ CD8+ T cells may be related to T cell dysfunction in AML, which may influence clinical outcome.
Duration matters: peer effects on academic achievement with random assignment in the Chinese context
Authors: Cheng Cheng 
Published: February 2020

AbstractThis paper goes beyond the most popular perspective of family social capital among existing research and examines the effect of peer social capital on adolescent academic achievement. Using the official data from a Chinese university and taking into account the endogeneity problems, this paper finds that peer academic performance has a significant effect on human capital accumulation among university students. We have different findings, however, from research abroad. First, peer social capital has an indirect rather than a direct effect. Second, the influence of initial randomly assigned peers tends to increase over time. However, this increase of influence is only present among peers from similar social class backgrounds. Among peers from different backgrounds, the influence remains almost unchanged. In addition to this, the influence of peer social capital is not significantly different among students from different social class backgrounds.
A systematic scorecard-based approach to site assessment in preparation for Lassa fever vaccine clinical trials in affected countries
Authors: Salami Kolawole , Imbault Nathalie , Erlebach Aljoscha , Urban Johanna , Zoglowek Mike , Tornieporth Nadia G. 
Published: February 2020

AbstractBackgroundWe sought to develop and test an objective scorecard-based system for assessing and categorizing available research sites in Lassa fever-affected countries based on their preparedness and capability to host Lassa fever vaccine clinical trials.MethodsWe mapped available clinical research sites through interrogation of online clinical trial registries and relevant disease-based consortia. A structured online questionnaire was used to assess the capability of clinical trial sites to conduct Lassa fever vaccine clinical trials. We developed a new scoring template by allocating scores to questionnaire parameters based on perceived importance to the conduct of clinical trials as described in the WHO/TDR Global Competency Framework for Clinical Research. Cutoff points of 75% and 50% were used to categorize sites into categories A, B, or C.ResultsThis study identified 44 clinical trial sites in 8 Lassa fever-affected countries. Out of these, 35 sites were characterized based on their capacity to hold Lassa fever vaccine clinical trials. A total of 14 sites in 4 countries were identified as ready to host Lassa fever vaccine trials immediately or with little support.ConclusionIt is feasible to hold Lassa fever vaccine trials in affected countries based on the outcome of the survey. However, the findings are to be validated through sites’ visits. This experience with a standardized and objective method of the site assessment is encouraging, and the site selection method used can serve as an orientation to sponsors and researchers planning clinical trials in the region.
Parent empowerment and coaching in early intervention: study protocol for a feasibility study
Authors: Pellecchia Melanie , Beidas Rinad S. , Mandell David S. , Cannuscio Carolyn C. , Dunst Carl J. , Stahmer Aubyn C. 
Published: February 2020

Abstract
Background
Parent-mediated early interventions (EI) for children with autism spectrum disorder (ASD) can result in significant improvements in children’s cognitive ability, social functioning, behavior, and adaptive skills, as well as improvements in parental self-efficacy and treatment engagement. The common component to efficacious parent-mediated early interventions for ASD is clinician use of parent coaching and occurs when a clinician actively teaches the parent techniques to improve their child’s functioning. Available evidence suggests that community-based EI clinicians rarely coach parents when working with families of these children, although specific barriers to coaching are unknown. This consistent finding points to the need to develop strategies to improve the use of parent coaching in community EI programs. The purpose of this community-partnered study is to iteratively develop and pilot test a toolkit of implementation strategies designed to increase EI clinicians’ use of parent coaching.

Methods
This study has four related phases. Phase 1: examine how EI clinicians trained in Project ImPACT, an evidence-based parent-mediated intervention, coach parents of children with ASD. Phase 2: identify barriers and facilitators to clinician implementation of parent coaching by administering validated questionnaires to, and conducting semi-structured interviews with, clinicians, parents, and agency leaders. Phase 3: partner with a community advisory board to iteratively develop a toolkit of implementation strategies that addresses identified barriers and capitalizes on facilitators to improve clinician implementation of evidence-based parent coaching. Phase 4: pilot test the feasibility and effectiveness of the implementation strategy toolkit in improving EI clinicians’ use of parent coaching with nine EI clinicians and parent-child dyads using a multiple-baseline-across-participants single-case design.

Discussion
Completion of these activities will lead to an in-depth understanding of EI clinicians’ implementation of parent coaching in usual practice following training in an evidence-based parent-mediated intervention, barriers to their implementation of parent coaching, a toolkit of implementation strategies developed through an iterative community-partnered process, and preliminary evidence regarding the potential for this toolkit to improve EI clinicians’ implementation of parent coaching. These pilot data will offer important direction for a larger evaluation of strategies to improve the use of parent coaching for young children with ASD.
Interference scores have inadequate concurrent and convergent validity: Should we stop using the flanker, Simon, and spatial Stroop tasks?
Authors: Paap Kenneth R. , Anders-Jefferson Regina , Zimiga Brandon , Mason Lauren , Mikulinsky Roman 
Published: February 2020

Abstract
Background
Two-hundred one college undergraduates completed four nonverbal interference tasks (Simon, spatial Stroop, vertical Stroop, and flanker) and trait scales of self-control and impulsivity. Regression analyses tested 11 predictors of the composite interference scores derived from three of the four tasks and each task separately. The purpose of the study was to examine the relationships between laboratory measures of self-control, self-report measures, and the degree to which control might be related to extensive experience in activities that logically require self-control.

Results
Fluid intelligence and sex were significant predictors of the composite measure, but bilingualism, music training, video gaming, mindfulness/meditation, self-control, impulsivity, SES, and physical exercise were not.

Conclusions
Common laboratory measures of inhibitory control do not correlate with self-reported measures of self-control or impulsivity and consequently appear to be measuring different constructs. Bilingualism, mindfulness/meditation, playing action video games, and music training or performance provide weak and inconsistent improvements to laboratory measures of interference control. Flanker, Simon, and spatial Stroop effects should not be used or interpreted as measures of domain-general inhibitory control.