bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatiotemporal trends of Chagas disease-related mortality in the Northeast of Brazil, 2007–2017
Authors: Sousa G. J. B. , Farias M. S. , Cestari V. R. F. , Garces T. S. , Maranhão T. A. , Moreira T. M. M. , Silva L. F. , Sales J. T. L. , Florêncio R. S. , Pereira M. L. D. 
Published: August 2020

AbstractChagas disease (CD) is a neglected disease and endemic in Brazil. In the Brazilian Northeast Region, it affects millions of people. Therefore, it is necessary to identify the spatiotemporal trends of CD mortality in the Northeast of Brazil. This ecological study was designed, in which the unit of analysis was the municipality of the Brazilian northeast. The data source was the Information System of Mortality. It was calculated relative risk from socioeconomic characteristics. Mortality rates were smoothed by the Local Empirical Bayes method. Spatial dependency was analysed by the Global and Local Moran Index. Scan spatial statistics were also used. A total of 11 287 deaths by CD were notified in the study. An expressive parcel of this number was observed among 70-year-olds or more (n = 4381; 38.8%), no schooling (n = 4381; 38.8%), mixed-race (n = 4381; 62.3%), male (n = 6875; 60.9%). It was observed positive spatial autocorrelation, mostly in municipalities of the state of Bahia, Piauí (with high-high clusters), and Maranhão (with low-low clusters). The spatial scan statistics has presented a risk of mortality in 24 purely spatial clusters (P < 0.05). The study has identified the spatial pattern of CD mortality mostly in Bahia and Piauí, highlighting priority areas in planning and control strategies of the health services.
Gross, microscopic, radiologic, echocardiographic and haematological findings in rats experimentally infected withAngiostrongylus cantonensis
Authors: Wun Matthew K. , Davies Sarah , Spielman Derek , Lee Rogan , Hayward Doug , Malik Richard 
Published: August 2020

AbstractAlthough the gross and microscopic pathology in rats infected withAngiostrongylus cantonensishas been well described, corresponding changes detected using diagnostic imaging modalities have not been reported. This work describes the cardiopulmonary changes in mature Wistar rats chronically infected with moderate burdens ofA. cantonensisusing radiology, computed tomography (CT), CT angiography, echocardiography, necropsy and histological examinations. Haematology and coagulation studies were also performed. Thoracic radiography, CT and CT angiography showed moderately severe alveolar pulmonary patterns mainly affecting caudal portions of the caudal lung lobes and associated dilatation of the caudal lobar pulmonary arteries. Presumptive worm profiles could be detected using echocardiography, with worms seen in the right ventricular outflow tract or straddling either the pulmonary and/or the tricuspid valves. Extensive, multifocal, coalescing dark areas and multiple pale foci affecting the caudal lung lobes were observed at necropsy. Histologically, these were composed of numerous large, confluent granulomas and fibrotic nodules. Adult worms were found predominantly in the mid- to distal pulmonary arteries. An inflammatory leukogram, hyperproteinaemia and hyperfibrinogenaemia were found in most rats. These findings provide a comparative model forA. cantonensisin its accidental hosts, such as humans and dogs. In addition, the pathological and imaging changes are comparable to those seen in dogs infected withAngiostrongylus vasorum, suggesting rats infected withA. cantonensiscould be a model for dogs withA. vasoruminfection.
Deep learning-based classification of posttraumatic stress disorder and depression following trauma utilizing visual and auditory markers of arousal and mood
Authors: Schultebraucks Katharina , Yadav Vijay , Shalev Arieh Y. , Bonanno George A. , Galatzer-Levy Isaac R. 
Published: August 2020

AbstractBackgroundVisual and auditory signs of patient functioning have long been used for clinical diagnosis, treatment selection, and prognosis. Direct measurement and quantification of these signals can aim to improve the consistency, sensitivity, and scalability of clinical assessment. Currently, we investigate if machine learning-based computer vision (CV), semantic, and acoustic analysis can capture clinical features from free speech responses to a brief interview 1 month post-trauma that accurately classify major depressive disorder (MDD) and posttraumatic stress disorder (PTSD).MethodsN= 81 patients admitted to an emergency department (ED) of a Level-1 Trauma Unit following a life-threatening traumatic event participated in an open-ended qualitative interview with a para-professional about their experience 1 month following admission. A deep neural network was utilized to extract facial features of emotion and their intensity, movement parameters, speech prosody, and natural language content. These features were utilized as inputs to classify PTSD and MDD cross-sectionally.ResultsBoth video- and audio-based markers contributed to good discriminatory classification accuracy. The algorithm discriminates PTSD status at 1 month after ED admission with an AUC of 0.90 (weighted average precision = 0.83, recall = 0.84, and f1-score = 0.83) as well as depression status at 1 month after ED admission with an AUC of 0.86 (weighted average precision = 0.83, recall = 0.82, and f1-score = 0.82).ConclusionsDirect clinical observation during post-trauma free speech using deep learning identifies digital markers that can be utilized to classify MDD and PTSD status.
Phonetic variation and change in the Cockney Diaspora: The role of place, gender, and identity
Authors: Cole Amanda , Evans Bronwen G. 
Published: August 2020

AbstractRecent research has suggested that two linguistic processes are displacing Cockney: the emergence of Multicultural London English (MLE) in inner London and dialect levelling (e.g. Kerswill & Williams 2005). This study investigates firstly whether Cockney phonetic features have ‘moved East’ to Essex (Fox 2015), and secondly the features’ indexicality in relation to place and identity. Fifty-four participants from Debden, an outpost of the Cockney Diaspora, completed a sociolinguistic interview. Vowel measurements were made from a wordlist and passage, and quantitative attitudinal and qualitative data were extracted from a questionnaire and interviews. Overall, changes in identity as a result of social change exceeded linguistic changes, and linguistic labels were not interpreted uniformly across the community. Whilst Cockney variants were largely maintained in young speakers, they were transposed onto an ‘Essex’ accent. Furthermore, some young women but no young men considered themselves Cockney, likely due to the matrifocal nature of Cockney. (Cockney, phonetic variation and change, dialect levelling, identity, indexicality, gender)
The partisan politics of the penal–welfare nexus: a quantitative analysis of party influence on the relationship between penal and welfare policies
Authors: Staff Helge , Wenzelburger Georg 
Published: August 2020

AbstractEvidence of a link between the retrenchment of the welfare state and the expansion of the penal state has sparked a debate about the existence of a nexus. In this study, we critically explore this link by focusing on political parties. First, we argue that welfare and penal policies are likely to follow distinct paths, with left-liberal/green parties pushing for less punitive penal and market-liberal/conservative parties for less generous welfare policy. Second, we only expect a nexus between both policy domains if conservative or “third way” social democratic governments are in power. The former follows a coherent ideology, the latter compensates for welfare retrenchment with tough-on-crime policies. We test these claims quantitatively on a unique dataset covering all changes to welfare and penal legislation in Denmark, Germany, the United Kingdom and France between 1990 and 2014 and find our expectations supported except conservative influence on the penal–welfare nexus.
Projecting effectiveness after ending a randomized controlled trial: a two-state Markov microsimulation model
Authors: Yuan Fei , Bangdiwala Shrikant I. , Tong Wesley , Lamy Andre 
Published: August 2020

ObjectiveTo investigate the behavior of restricted mean survival time (RMST) and designs of a two-state Markov microsimulation model through a 2 × 4 × 2 full factorial experiment.MethodBy projecting patient-wise 15-year-post-trial survival, we estimated life-year-gained between an intervention and a control group using data from the Cardiovascular Outcomes for People Using Anticoagulation Strategies Study (COMPASS). Projections considered either in-trial events or post-trial medications. They were compared based on three factors: (i) choice of probability of death, (ii) lengths of cycle, and (iii) usage of half-a-cycle age correction. Three-way analysis of variance and post-hoc Tukey's Honest Significant Difference test compared means among factors.ResultsWhen both in-trial events and post-trial study medications were considered, monthly, quarterly, or semiannually were not different from one other in projected life-year-gained. However, the annual one was different from the others: mean and 95 percent confidence interval 252.2 (190.5–313.9) days monthly, 251.8 (192.0–311.6) quarterly, 249.1 (189.7–308.5) semiannually, and 240.8 (178.5–303.1) annually. The other two factors also impacted life-year-gained: background probability (269.1 [260.3–277.9] days projected with REACH-based-probabilities, 227.7 [212.6–242.8] with a USA life table); half-a-cycle age correction (245.5 [199.0–292] with correction and 251.4 [209.1–293.7] without correction). When not considering post-trial medications, only the choice of probability of death appeared to impact life-year-gained.ConclusionFor a large trial or cohort, to optimally project life-year-gained, one should consider using (i) annual projections, (ii) life table probabilities, (iii) in-trial events, and (iv) post-trial medication use.
Evaluation of an ensemble-based distance statistic for clustering MLST datasets using epidemiologically defined clusters of cyclosporiasis
Authors: Nascimento Fernanda S. , Barratt Joel , Houghton Katelyn , Plucinski Mateusz , Kelley Julia , Casillas Shannon , Bennett Carolyne (Cody) , Snider Cathy , Tuladhar Rashmi , Zhang Jenny , Clemons Brooke , Madison-Antenucci Susan , Russell Alexis , Cebelinski Elizabeth , Haan Jisun , Robinson Trisha , Arrowood Michael J. , Talundzic Eldin , Bradbury Richard S. , Qvarnstrom Yvonne 
Published: August 2020

Abstract
Outbreaks of cyclosporiasis, a food-borne illness caused by the coccidian parasite Cyclospora cayetanensis have increased in the USA in recent years, with approximately 2300 laboratory-confirmed cases reported in 2018. Genotyping tools are needed to inform epidemiological investigations, yet genotyping Cyclospora has proven challenging due to its sexual reproductive cycle which produces complex infections characterized by high genetic heterogeneity. We used targeted amplicon deep sequencing and a recently described ensemble-based distance statistic that accommodates heterogeneous (mixed) genotypes and specimens with partial genotyping data, to genotype and cluster 648 C. cayetanensis samples submitted to CDC in 2018. The performance of the ensemble was assessed by comparing ensemble-identified genetic clusters to analogous clusters identified independently based on common food exposures. Using these epidemiologic clusters as a gold standard, the ensemble facilitated genetic clustering with 93.8% sensitivity and 99.7% specificity. Hence, we anticipate that this procedure will greatly complement epidemiologic investigations of cyclosporiasis.
High intensities of population movement were associated with high incidence of COVID-19 during the pandemic
Authors: Yang Huikuan , Chen Dandan , Jiang Qunfang , Yuan Zhaohu 
Published: August 2020

Abstract
Increased population movements and increased mobility made it possible for severe acute respiratory syndrome coronavirus 2, which is mainly spread by respiratory droplets, to spread faster and more easily. This study tracked and analysed the development of the coronavirus 2019 (COVID-19) outbreak in the top 100 cities that were destinations for people who left Wuhan before the city entered lockdown. Data were collected from the top 100 destination cities for people who travelled from Wuhan before the lockdown, the proportion of people travelling into each city, the intensity of intracity travel and the daily reports of COVID-19. The proportion of the population that travelled from Wuhan to each city from 10 January 2020 to 24 January 2020, was positively correlated with and had a significant linear relationship with the cumulative number of confirmed cases of COVID-19 in each city after 24 January (all P < 0.01). After the State Council launched a multidepartment joint prevention and control effort on 22 January 2020 and compared with data collected on 18 February, the average intracity travel intensity of the aforementioned 100 cities decreased by 60−70% (all P < 0.001). The average intensity of intracity travel on the nth day in these cities during the development of the outbreak was positively related to the growth rate of the number of confirmed COVID-19 cases on the n + 5th day in these cities and had a significant linear relationship (P < 0.01). Higher intensities of population movement were associated with a higher incidence of COVID-19 during the pandemic. Restrictions on population movement can effectively curb the development of an outbreak.
Ongoing tuberculosis transmission among second-generation Ethiopian immigrants
Authors: Bishara H. , Green M. , Chemtob D. , Saffouri A. , Zelikman L. , Weiler-Ravell D. 
Published: August 2020

Abstract
Despite considerable efforts to control tuberculosis (TB) among Ethiopian immigrants in Israel, an outbreak of TB among second-generation Ethiopian immigrants that involved native Israelis occurred between January 2011 and December 2019. The aim of this article is to report on this outbreak and discuss the patient and health system barriers that led to its propagation. Overall, 13 culture-positive TB patients were diagnosed in this outbreak. An additional 36 cases with identical mycobacterium tuberculosis genotypes were identified through cross-checking with the National TB Laboratory Registry. Among the 32 close contacts of the index case, 18 (56.3%) reported for screening and treatment of latent TB infection (LTBI) was recommended for 11 (61.1%) of them. However, none completed treatment and eight eventually developed TB. Of the 385 close contacts identified in this outbreak, 286 (74.3%) underwent contact investigation, 154 (53.8%) were recommended LTBI treatment, but only 26 (16.9%) completed the treatment. Routine contact investigation and treatment practice measures failed to contain the cascade of infection and disease, leading to the spread of the infecting strain of TB. This report highlights the challenges to identify the high-risk group and address barriers to care among such a vulnerable population.
Bench over Ballot: The Fight for Judicial Supremacy and the New Constitutional Politics, 1910–1916
Authors: Istre Logan Stagg 
Published: August 2020

AbstractThe nature of American constitutional politics was forever changed during the Progressive Era. In the nineteenth century, the process of constitutional interpretation was a vague and decentralized enterprise balanced between the courts and the public square. The meaning of the Constitution was decided as much at the polls or on the battlefield as in court opinions. This balance started to give way at the turn of the century as federal courts began asserting greater authority in the definition of constitutional bounds. “Bench over Ballot” illustrates how the assertion of judicial supremacy in the Progressive Era precipitated a fight that upended the traditional dynamic of American politics. Populist-progressives championed the people's ultimate right to correct judicial decisions while traditionalist-conservatives stood for judicial supremacy to ensure a “government of laws.” The outcome of the political battle in 1912 was a consensus between Wilsonian progressives and Taftian conservatives in favor of judicial supremacy that banished the notion of popular supremacy and transformed the nature of constitutional politics from a popular, decentralized process to a vicious battle over the personal composition of the bench—a phenomenon deeply familiar over a century later.
The constitutional economics of the World Health Organization
Authors: Ip Eric C. 
Published: August 2020

AbstractThis paper brings a constitutional economics perspective to bear on the World Health Organization (WHO), the flagship United Nations intergovernmental health organisation, which is obligated by its Constitution to achieve ‘the highest possible level of health’ for the world's peoples. The WHO has in the seven decades of its existence used its formidable legislative powers only sparingly. It has been widely chided for being weak in regional coordination and unresponsive to transnational emergencies like the West African Ebola outbreak of 2014–2016. In 2020, it found itself at the centre of the COVID-19 pandemic and in the middle of the Sino-American geopolitical tug-of-war. This paper traces the discordance between the Constitution's stated purposes and the actual track record of the WHO not back to its organisational culture nor to weak leadership but to the design of the Constitution itself. It analytically distinguishes the Constitution's expressive from its instrumental halves, and shows that, whilst the former embodies a ‘constitutional moment’ of international health solidarity right after the Second World War, the latter embodies a reserved and limited delegation from member-states that are jealous of their sovereignty.
Widowhood and mortality: a Danish nationwide register-based cohort study
Authors: Blanner C. , Mejldal A. , Prina A. M. , Munk-Jørgensen P. , Ersbøll A. K. , Andersen K. 
Published: August 2020

AbstractAimsWidowed people have increased mortality compared to married people of the same age. Although most widowed people are of older age, few studies include the oldest old. As life expectancy is increasing, knowledge of widowhood into older age is needed. This study aimed to examine mortality and widowhood in older age by comparing mortality in widowed and married people by sex, age, time since spousal loss and cause of death.MethodsA Danish register-based matched cohort study of 10% of widowed persons ⩾65 years in the years 2000–2009. For each randomly drawn widowed person, five married persons were matched on sex and age. Mortality rate ratios (MRR) were calculated using Poisson regression, and stratified according to sex and 5-year age intervals. MRRs were furthermore calculated by time since spousal loss and by specific cause of death.ResultsThe study included 82 130 persons contributing with 642 914.8 person-years. The overall MRR between widowed and married persons with up to 16 years of follow-up was 1.25 (95% CI 1.23–1.28). At age ⩾95 years for men, and ⩾90 years for women, no differences in mortality rates were seen between widowed and married persons. Mortality in widowed persons was increased for most specific causes of death, with the highest MRR from external causes (MRR 1.53 [1.35–1.74]) and endocrine diseases (MRR 1.51 [1.34–1.70]).ConclusionsWidowhood was associated with increased mortality in older age for both men and women until age ⩾95 and ⩾90 years, respectively. Increased mortality was observed for almost all causes of death.
The Emotional Attentional Blink as a Measure of Patriotism
Authors: Aznar-Casanova José Antonio , Gavilán José M. , Moreno Sánchez Manuel , Haro Juan 
Published: August 2020

Abstract
This study aims to explore whether the implicit processing of emotional symbols related to patriotic feeling may exert some effects on attention. Here, we have conducted an experiment using two interrelated tasks. First, we use flags with different meanings to participants for measuring the strength of the emotional attentional blink (EAB) within a rapid serial visual presentation (RSVP) paradigm. Then, we use a “congruency judgments” subjective test, where we confront participants to judge the affinity between pairs of politician leaders and flags of different sign for community participants, while recording two physiological measures (Heart Rate Variance and Galvanic Skin Response) to evaluate the variations elicited by that confrontation. Results on the EAB task show a significant emotion induced blindness for emotional stimuli representing Catalan and Spanish patriotism (α = .05), while the effect does not appear for the stimulus representing neutral patriotism. The interaction “Flags x Patriotism” was significant, F(1, 51) = 4.62; p = .036; ηp2 = .083. Results on the second task show that measures derived from electrophysiological records are sensitive to patriotic feeling, both being complementary. In addition, by using measures of congruence, the “Leaders x Flags” interaction was significant, F(3.682, 125.204) = 53.55; p < .001; ηp2 = .612. Finally, a multiple linear regression model for each emotional inductor was verified for the Catalan case, using the EAB effect as criteria, R2Adjusted = .79; p < .001. Some theoretical and methodological aspects derived of this exploratory study are discussed.
Assessment and Integration of Bulk and Component‐Specific Methods for Identifying Mineral Magnetic Assemblages in Environmental Magnetism
Authors: Qian Yao , Roberts Andrew P. , Liu Yan , Hu Pengxiang , Zhao Xiang , Heslop David , Grant Katharine M. , Rohling Eelco J. , Hennekam Rick , Li Jinhua 
Published: August 2020

AbstractMagnetic parameters are used extensively to interpret magnetic mineral assemblage variations in environmental studies. Conventional room temperature measurements of bulk magnetic parameters, like the anhysteretic remanent magnetization (ARM) and the ratio of the susceptibility of ARM to magnetic susceptibility (χ), can reflect, respectively, magnetic mineral concentration and/or particle size variations in sediments, although they are not necessarily well suited for identifying magnetic components within individual magnetic mineral assemblages. More advanced techniques, such as first‐order reversal curve (FORC) diagrams and low‐temperature (LT) magnetic measurements, can enable detailed discrimination of magnetic assemblages. Here, we integrate conventional bulk magnetic measurements alongside FORC diagrams, LT measurements, and X‐ray fluorescence core‐scan data, transmission electron microscope observations, and principal component analysis of FORC diagrams to identify and quantify magnetic mineral assemblages in eastern Mediterranean sediments. The studied sediments were selected because they contain complexly varying mixtures of detrital, biogenic, and diagenetically altered magnetic mineral assemblages that were deposited under varying oxic (organic‐poor marls) to anoxic (organic‐rich sapropels) conditions. Conventional bulk magnetic parameters provide continuous records of environmental magnetic variations, while more time‐consuming LT and FORC measurements on selected samples provide direct ground‐truthing of mineral magnetic assemblages that enables calculation of magnetization contributions of different end members. Thus, a combination of conventional bulk parameters and advanced magnetic techniques can provide detailed records from which the meaning of environmental magnetic signals can be unlocked.