bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of Coumarin Derivatives as Versatile Scaffolds for GSK-3β Enzyme Inhibition
Authors: Francisco Carla S. , Javarini Clara L. , de S. Barcelos Iatahanderson , Morais Pedro A.B. , de Paula Heberth , de S. Borges Warley , Neto Álvaro Cunha , Lacerda Valdemar 
Published: October 2019

Background:
Glycogen synthase kinase-3 (GSK-3) is involved in the phosphorylation and
inactivation of glycogen synthase. GSK-3 inhibitors have been associated with a variety of diseases, including
Alzheimer´s disease (AD), diabetes type II, neurologic disorders, and cancer. The inhibition of
GSK-3β isoforms is likely to represent an effective strategy against AD.

Objective:
The present work aimed to design and synthesize coumarin derivatives to explore their potential
as GSK-3β kinase inhibitors.

Method:
The through different synthetic methods were used to prepare coumarin derivatives. The
GSK-3β activity was measured through the ADP-Glo™ Kinase Assay, which quantifies the kinasedependent
enzymatic production of ADP from ATP, using a coupled-luminescence-based reaction. A
docking study was performed by using the crystallographic structure of the staurosporine/GSK-3β complex
[Protein Data Bank (PDB) code: 1Q3D].

Results:
The eleven coumarin derivatives were obtained and evaluated as potential GSK-3β inhibitors.
Additionally, in silico studies were performed. The results revealed that the compounds 5c, 5d, and 6b
inhibited GSK-3β enzymatic activity by 38.97–49.62% at 1 mM. The other coumarin derivatives were
tested at 1 mM, 1 µM, and 1 nM concentrations and were shown to be inhibitor candidates, with significant
IC50 (1.224–6.875 µM) values, except for compound 7c (IC50 = 10.809 µM). Docking simulations
showed polar interactions between compound 5b and Lys85 and Ser203, clarifying the mechanism of the
most potent activity.

Conclusion:
The coumarin derivatives 3a and 5b, developed in this study, showed remarkable activity
as GSK-3β inhibitors.
Network Selection in Wireless Heterogeneous Environment Based on Available Bandwidth Estimation
Authors: Ahuja Kiran , Singh Brahmjit , Khanna Rajesh 
Published: October 2019

Background:
With the availability of multiple options in wireless network simultaneously,
Always Best Connected (ABC) requires dynamic selection of the best network and access technologies.

Objective:
In this paper, a novel dynamic access network selection algorithm based on the real time
is proposed. The Available BandWidth (ABW) of each network is required to be estimated to solve
the network selection problem.

Methods:
Proposed algorithm estimates available bandwidth by taking averages, peaks, low points
and bootstrap approximation for network selection. It monitors real-time internet connection and resolves
the selection issue in internet connection. The proposed algorithm is capable of adapting to
prevailing network conditions in heterogeneous environment of 2G, 3G and WLAN networks without
user intervention. It is implemented in temporal and spatial domains to check its robustness. Estimation
error, overhead, estimation time with the varying size of traffic and reliability are used as
the performance metrics.

Results:
Through numerical results, it is shown that the proposed algorithm’s ABW estimation
based on bootstrap approximation gives improved performance in terms of estimation error (less
than 20%), overhead (varies from 0.03% to 83%) and reliability (approx. 99%) with respect to existing
techniques.

Conclusion:
Our proposed methodology of network selection criterion estimates the available
bandwidth by taking averages, peaks, and low points and bootstrap approximation method (standard
deviation) for the selection of network in the wireless heterogeneous environment. It monitors realtime
internet connection and resolves internet connections selection issue. All the real-time usage
and test results demonstrate the productivity and adequacy of available bandwidth estimation with
bootstrap approximation as a practical solution for consistent correspondence among heterogeneous
wireless networks by precise network selection for multimedia services.
Dinámicas de endomarketing en el restaurante de comidas rápidas FRISBY S.A.- Valentina Alzate – Natalia Sosa – Laura Gutierrez
Authors: Alzate Salazar Valentina , Sosa Rey Natalia Andrea , Gutiérrez Escobar Laura Patricia 
Published: October 2019

La investigación es realizada en el restaurante de comidas rápidas FRISBY S.A de la ciudad de Pereira durante el año 2015, para conocer sus dinámicas de endomarketing y la construcción de marca. Va dirigida a los colaboradores de los restaurantes FRISBY S.A de Pereira de forma cualitativa. El endomarketing ha sido estudiado desde hace más de 25 años; Berry es una de las mayores referencias y un pionero del endomarketing; pues, en 1981 fue el primero en llamar a los empleados clientes internos. Este enfoque surgió por la necesidad de mejorar la gestión de personas y la atención a los clientes. El tratamiento empírico incentivó diversas interpretaciones y conceptualizaciones sobre el tema; como consecuencia surgieron distintas aplicaciones en la forma de desarrollo de metodologías con algunos puntos en común como la satisfacción del empleado y el cliente. El endomarketing, es un conjunto de estrategias que se han empezado a implementar en un gran número de empresas alrededor del mundo. Estas estrategias están orientadas a “vender” la empresa a los propios empleados que la conforman y tengan sentido de pertenencia. Los recursos humanos son una de las mayores bases para una organización y la obtención de una ventaja competitiva aplicada en uno de los modelos de marketing interno como lo es el modelo de Berry. De esta dinámica, se genera la importancia del análisis de la gestión de recursos. Por ello; en el restaurante de comidas rápidas pereirano, FRISBY S.A, se analiza la evolución, desarrollo y dinámicas del marketing interno.
Intelligent Process Automation in Audit
Authors: Zhang Chanyuan (Abigail) 
Published: October 2019

ABSTRACTIntelligent process automation (IPA) achieves flexible and intelligent automation by combining robotic process automation (RPA), artificial intelligence (AI), and other emerging technologies. This paper focuses on the utility of IPA for the audit profession. Specifically, this paper provides a framework for implementing IPA in audit engagements using the concept of audit workflow. A simple prototype based on a simulated use case is constructed to illustrate the IPA implementation framework. The potential applications of IPA in pension and inventory audits are provided, and the expected impacts of IPA on audit efficiency and effectiveness are discussed.
Mandibular dental changes following serial and late extraction of mandibular second premolars
Authors: Mintenko Rob , Kennedy David B. , Aleksejuniene Jolanta , Hannam Alan G. , Yen Edwin H. 
Published: October 2019

ABSTRACT

Objectives:
To determine changes in occlusal curves and dental tipping occurring from mandibular second premolar serial extraction, early extraction of deciduous mandibular second molars with missing second premolars, and late second premolar extraction compared with untreated controls.

Materials and Methods:
Information was collected from 85 subjects at three time points: T0, prior to serial extraction; T1, after serial extraction and drift prior to orthodontic treatment, and pretreatment for the late premolar extraction patients; and T2, posttreatment. Untreated age- and gender-matched controls were used for comparison. Three occlusal curves were measured on digitized mandibular casts, and dental tipping was assessed using lateral cephalograms.

Results:
At T0, there were no significant differences among groups. At T1, there was significant steepening of Monson's sphere and the curve of Wilson between early and late extraction and control groups. At T2, the differences in Monson's sphere and the curve of Wilson were fully corrected. At T1, there were significant differences in the tipping of mandibular 6's, 4's, and 3's between the early extraction groups compared with the late extraction and control groups. At T2, these differences in tipping were fully corrected. There were no differences in mandibular incisor tipping between groups at T1 or T2.

Conclusions:
Serial extraction produced steeper occlusal curves and significant tipping of mandibular first molars, first premolars, and canines after extraction and physiologic drift (T1). Accentuated occlusal curves and tooth tipping were fully corrected following orthodontic treatment (T2). Mandibular incisor position was unchanged by serial or late second premolar extraction.
Students’ Attitudes Towards Research and Dissertations in a Mexican Southeastern University
Authors: Obermeier Pérez Martha Lorena 
Published: October 2019

Investigaciones realizadas en ámbitos universitarios se han enfocado en estudiar el síndrome todo menos tesis. Existen numerosas evidencias de que este problema persiste en diversas instituciones educativas en países Latino Americanos. Las intervenciones realizadas no han tenido los resultados esperados. El objetivo de este estudio realizado en una Universidad del Sureste de México fue medir la actitud que los alumnos de una licenciatura presencial tienen hacia la investigación. Se pretendió determinar si tanto los docentes como las condiciones institucionales fomentan este tipo de actividades. Estos conceptos habían sido medidos anteriormente en un estudio previo en la modalidad virtual del mismo programa. Este estudio fue mixto de tipo convergente con la variante de cuestionario y se eligió una muestra no probabilística. Este enfoque fue utilizado para comprender las razones por las que se niegan a escribir una tesis.
Los resultados muestran que un alto porcentaje de los alumnos no contempla la opción de titularse por tesis y prefiere otras modalidades aceptadas por la institución. Se determinó que la actitud hacia la investigación es baja, que los docentes del programa no realizan investigación y que la tutoría que ofrecen en este tipo de trabajos no es adecuada. Igualmente, se encontró que las condiciones institucionales tampoco fomentan las actividades de investigación. Si bien los alumnos consideran importante este tipo de formación, desconocen la existencia de cuerpos académicos y no se les incluye en este tipo de proyectos. Se concluye que es necesario realizar estudios en otras facultades para determinar si el problema prevalece en el resto de la institución. También se recomienda fomentar la formación en investigación de los docentes que imparten las materias de metodología en el programa.
Pengaruh Penalaran Moral dan Sensitivitas Etika Terhadap Persepsi Etis dengan Gender Sebagai Variabel Moderasi
Authors: Jasmine Theresia Joycelin , Susilawati Clara 
Published: October 2019

Accounting profession is required to provide true financial information and give confidence to users of financial information. However, many accounting scandals eroded people trust in the accounting profession. Therefore, it is important for prospective accountants to have understanding and knowledge in regard with ethical and moral values. This study examine moderating effect of gender on the the relationship between moral reasoning and ethical perceptions and between ethical sensitivity and ethical perceptions. If accounting students have higher moral reasoning dan ethical sensitivity, the ethical perceptions of accounting students are also predicted to be higher. This study examines moral reasoning and ethical sensitivity to ethical perceptions of accounting students with gender as a moderating variabel using a sample of students from 13 universities in Semarang. This study uses simple regression analysis and moderating regression analysis (MRA). Results show gender effect the relationship between moral reasoning and ethical perceptions, but hass no effect on relationship between ethical sensitivity and ethical perceptions of accounting students.

Abstrak
Profesi akuntansi dituntut memberikan informasi keuangan yang benar dan memiliki etika sehingga memberikan kepercayaan kepada pengguna informasi keuangan. Namun, banyaknya skandal akuntansi menurunkan kepercayaan terhadap profesi akuntansi. Oleh karena itu, penting bagi calon akuntan memiliki pemahaman dan pengetahuan berperilaku berdasarkan nilai etis dan moral. Penelitian ini menguji efek moderasi gender terhadap hubungan antara penalaran moral dan persepsi etis dan hubungan antara sensitivitas etika dan persepsi etis mahasiswa akuntansi. Jika mahasiswa akuntansi memiliki penalaran moral dan sensitivitas etika yang tinggi maka persepsi etis mahasiswa akuntansi tersebut juga tinggi. Penelitian ini menggunakan sampel mahasiswa dari 13 Universitas di Semarang. Penelitian ini menggunakan analisis regresi sederhana dan moderating regression analysis (MRA). Hasil penelitian menunjukkan bahwa gender mempengaruhi hubungan antara penalaran moral dan sensitivitas etis tetapi tidak mempengaruhi hubungan antara penalaran moral dan persepsi etis mahasiswa akuntansi.
Tipografia e a prática do ensino no curso Design Gráfico | Typography and the teaching practice in graphic design courses
Authors: Costa Tadeu Luis da 
Published: October 2019

Neste artigo, é apresentado o processo de ensino da Tipografia no curso Design Gráfico como prática para formar o senso crítico do aluno como designer tipográfico. Apresenta-se o universo que envolve a origem, a formação, as configurações e os processos de reprodução gráfica, para auxiliar o estudo da forma e a contraforma do caractere. É fundamental pesquisar e desenhar para educar a leitura crítica da anatomia, transferindo esse entendimento para o desenho do alfabeto na produção de vetores. Entende-se, naconclusão, que o aprendizado do aluno tem avanços consistentes durante o processo, porém, ainda segmentado, ele responde às demandas do grupo e profissionais nos mais distintos suportes.
Hacer de la vida una forma propia
Authors: Harispe Isidoro 
Published: October 2019

El presente artículo pretende reflexionar sobre la particular mirada que tiene Giorgio Agamben de lo político a partir del uso que hace de algunos autores (Debord, Heidegger, Foucault, Kojève) y conceptos (“espectáculo”, “poshistoria”, “vida”, “forma-de-vida”) con los cuales durante más de veinte años abordó cuestiones del pensamiento político contemporáneo. El recorrido interpretativo está centrado entre los años de la publicación de Medios sin fin (1996), un libro pequeño pero bisagra en su producción escritural, y el final de la saga Homo Sacer El uso de los cuerpos (2014).
Palabras clave: Giorgio Agamben. Guy Debord. Sociedad del espectáculo. Vida. Forma-de-vida. Poshistoria.
Research and development in the field of Artificial Intelligence in EU framework programmes
Authors: Kučera Zdeněk , Vondrák Tomáš , Pecha Odřej 
Published: October 2019

Abstract
The aim of this contribution is to evaluate the cooperation of the European countries in projects related to the AI in the 7th Framework Programme (FP7) and in the current Horizon 2020 Programme. The analysis is based on the information obtained from European Commission database eCORDA (External COmmon Research DAtawarehouse). Dynamic scientometric maps were constructed to describe in more detail the collaboration of European subjects in the EC funded AI research. Within the FP7, 1223 projects in the AI field received roughly 2,8 billion €. In the current H2020 programme the EC has already provided 2,1 billion € for 1081 projects in AI. In the FP7, higher education institutions dominated in both the number of awarded project and the received financial support. In the H2020 programme, a profound shift favouring business enterprise sector occurred. Approximately one third of AI projects in the FP7 was in the thematic area Information and Communication Technologies. In the H2020 programme the EC extended the support further to other thematic areas including global societal challenges especially in the field of transport and security. The extent of the involvement of the member countries varies extensively. The countries above average participating in the AI projects are Germany, Italy, Austria, Spain, Portugal, and Slovenia. The Czech Republic falls in the group of less participating countries. The Czech Republic also exhibits a smaller increase of the participation between RP7 and H2020. Universities involved in approximately two thirds of AI project have dominated in the Czech participation in the FP7. In the H2020 program their share in the AI project decreased by approximately 10 percent points. On the other side, their share of financial support was conserved. The most participating universities were the Czech Technical University Prague (24 projects, and 30% share of the EC contribution for the Czech AI projects) and the Brno University of Technology (14 projects, and 12,4% financial share). In the business enterprise sector Honeywell International s. r. o. attained the highest participation. The Czech subjects collaborate most frequently with German, British, Italian and French research teams.
Structure and performance optimization of phenol polyphosphazene grafted by 2,4-dinitroaniline containing small nonlinear optical molecules
Authors: Zhang Ying , Li You 
Published: October 2019

Abstract
Electro-optic (EO) polymers, possessing high EO coefficient and low dielectric constant, are considered to be a new generation of nonlinear optical materials that have great application prospect in photo-communication, information storage, and data processing. The host-guest structure of EO polymers is the most typical one in this field. However, the phase separation during polarization between the host polymer and the guest nonlinear optical molecule (NLO) limits potential applications of the material. To solve the problem, a new synthetic method was designed in this paper. First, 2,4-dinitroaniline was grafted to phenol polyphosphazene by chemical method for polar improvement of the main chain. Then, another small NLO molecule was mixed into the polymer by physical method for further improvement of EO coefficient. The preparation process was studied and the structure of the product was characterized. The effects of different NLO mixing proportions and different polarizing temperatures on EO coefficient were investigated in details. Orientation stability of the sample was tested. Experimental results show that our products possess not only high EO coefficient but also good phase stability, which makes them good candidates for the application in information technology.
Motivation Psychological Characteristics of Canoe-Kayak Sprint Elite Youth Athletes
Authors: Bebetsos Evangelos , Aggelakis Emmanuel , Bebetsos George , Gargalianos Dimitrios 
Published: October 2019

Abstract
The objective of the current study was the investigation of anxiety and satisfaction levels among Elite Greek Youth athletes of Canoe-Kayak Sprint. Additionally, whether elements such as gender, age, athletic experience, and weekly practice-time, differentiated the sample. 122 athletes, (61 males and 61 females) between the ages of 15-17 yrs. old, who competed in the Hellenic Federation’s Canoe-Kayak Sprint National Championships. Study participants were invited to complete two questionnaires: a) the Greek version of “CSAI-2” (Stavrou, Zervas, Kakkos, & Psichoundaki, 1998), and b) the Greek version of the “Athlete Satisfaction” scale (Bebetsos & Theodorakis, 2003). Results of the conducted study revealed that the sample differentiated: a) on somatic, and cognitive anxiety, according to their athletic experience, and b) on somatic, and cognitive anxiety, self-confidence, leadership, and personal outcome, according to their weekly practice-time. Finally, no sex differences were found in any questionnaire variable. In conclusion, the survey results highlighted the importance of the psychological factors tested on Canoe-Kayak Sprint athletes’ performance. Knowing and understanding athletes’ psychological state, can help them out (the athletes) in identifying aspects such as stress and satisfaction that directly affect their racing performance.
ANALISA PERBANDINGAN ALTERNATIF DESAIN DAN RAB MENGGUNAKAN STRUKTUR BAJA DENGAN BETON PADA PROYEK KONSTRUKSI GEDUNG ASRAMA PMY BAUCAU
Authors: Tistogondo Julistyana 
Published: October 2019

Perencanaan ulang struktur atasbaja dengan struktur atasbeton pada struktur pembangunan asrama PMY Baucau, ukuran denah yang terdiri dari 2 lantai dan tinggi gedung ini bertujuan : 1.) untuk mendesain dimensi struktur atas seperti kolom, balok dan pelat, 2.) untuk menghitung beban rencana gravitasi dan seismik pada bangunan, 3.) untuk menentukan tulangan balok dan kolom dengan sistem rangka pemikul momen khusus (SRPMK) dan analisis struktur tersebut menggunakan SAP2000.V14, 4.) untuk membuat perbandingan RAB, guna mengetahui nilai ekonomis dari kedua alternative struktur tersebut. Perhitungan struktur beton mengacu pada SNI 2847-2013, perhitungan gempa mengacu pada SNI 1726-2012 dan perhitungan RAB mengacu harga upah dan bahan dari Timor-Leste.
Dari hasil perhitungan struktur beton didapatkan dimensi-dimensi struktur beton diantaranya balok , ,dan , kolom , pelat lantai untuk lantai 1 dan untuk lantai. Untukpondasididapatkanmenggunakan pondasiFoot Plate dengan ukuran kolom, dan ukuran pondasi. Hasil rencana anggaran biaya untuk kedua alternative strukturadalahsebagaiberikut :untuk alternative struktur atasbeton adalahdanuntuk alternative struktur atasbaja adalah .Berdasarkanhasil perhitungan alternative RAB kedua struktur tersebut didapatkanbahwa struktur atasbeton lebih ekonomis dibandingkan struktur atasbaja.

Kata Kunci : Struktur Beton Bertulang, Perbandingan RAB Struktur Atas Alternative Baja dan Beton
Enseñanza de idiomas extranjeros: Dogmatismo o Eclecticismo
Authors: Vanegas R. Luis Evalio 
Published: October 2019

Idealmente, los materiales utilizados para la enseñanza - aprendizaje de idiomas extranjeros están determinados por un enfoque lingüístico específico, el cual genera uno o varios métodos y éstos a la vez marcan la ruta de las actividades que se deben desarrollar en el salón de clase.
El diseño y producción de esos materiales están dominados por las editoriales (compañías multinacionales especialmente) las cuales se disputan el mercado inundándolo de “nuevos” textos, haciendo uso de todos los medios publicitarios posibles para garnárselo y, desde luego, colocando al profesor en una encrucijada cuando va a seleccionar “el libro guía” el cual algunas veces se identifica, o refleja un enfoque y un método bien fundamentado, y algunas otras, refleja que los “cambios” se deben más a parámetros de rentabilidad económica que a conceptos de lingüística aplicada.
Significado del arte en la educación
Authors: Ardila A. Jose Antonio 
Published: October 2019

El niño al realizar un dibujo, construir un objeto, o al pintar algo, proporciona algo más que el simple dibujo, nos proporciona una parte de sí mismo: cómo piensa, cómo siente, cómo ve. ¿Tenemos en cuenta realmente en nuestro sistema educativo los valores humanos?
Nuestro actual sistema de educación, asigna mucha importancia al aprendizaje de la correcta información acerca de hechos. En gran medida, el aprobar o no un examen o un curso, pasar al próximo, o incluso permanecer en la escuela, dependen del dominio o de la memorización de ciertos fragmentos de información, que ya conoce el maestro. De esta manera, la función de la enseñanza parecería reducirse a formar gente capaz de coleccionar partes de información y repetirla a una señal dada.