bluuebunny/crossref_metadata_2025_split huggingface dataset:
A study of development mode in green campus to realize the sustainable development goals
Authors: Zhu Bifeng , Zhu Chufan , Dewancker Bart 
Published: May 2020

Purpose
The purpose of this paper is to focus on the way to achieve the sustainable development goals (SDGs). Through the introduction and learning of a specific case, this paper summarizes the specific process of green campus’s development and construction and directly discusses how to achieve the goal of sustainable development. By analyzing the achievements and measures of its construction, on the one hand, the experience and shortcomings of its green campus construction are summarized; on the other hand, the impact of Stanford’s own green campus construction on the local community is discussed.

Design/methodology/approach
This paper takes Stanford, one of the best green campuses assessed by sustainability tracking, assessment and rating system (STARS), as a case study in three steps. First, it introduces the academics, energy supply and demand, water and land, waste, management, food and living, buildings and transportation of its campus construction in detail; second, it uses the STARS to make a comprehensive sustainable evaluation of Stanford; finally, it discusses the development relationship between Stanford and local community.

Findings
The four characteristics of its green campus development model are summarized, namely, based on its own scientific research; from the aspect of environmental friendliness; to achieve joint participation; and forming complementary development with the community. The construction of green campus has changed from a single triangle framework composed of SDGs, STARS and universities to a compound triangle framework composed of SDGs, universities and communities on the existing basis, greatly expanding the way to realize SDGs.

Practical implications
This development mode will have direct guiding significance for the sustainable construction of other campuses.

Social implications
This paper also discusses the development concept from green campus to sustainable community to provide positive reference to achieve the global SDGs from the perspective of colleges and universities.

Originality/value
According to the historical track of its development, this paper combines the two (SDGs and green campus) to discuss by using campus construction as an effective way to achieve the SDGs. On the basis of literature research and case study, STARS sustainable assessment is introduced. This will lead to quantitative analysis of sustainable construction in the discussion of the specific case, judging the specific sustainable degree of all aspects of campus construction, to provide a scientific basis for summarizing its characteristics of development mode.
Study on Chinese Brand cultural archetype: theory building and cross-cultural comparison
Authors: Liu Yingwei , Wang Tao , Zhou Ling , Nie Chunyan 
Published: May 2020

PurposeThe essence of “Chinese element” has been pinpointed as the representation of national cultural archetype resource of China, which reflects to the overall power enhancement of China. Applying the Chinese national cultural archetype resource, which will be used for promoting the Chinese Brand internationalization, aims for the consumers' approval with the hope of integrating and spreading the unique cultural advantage of Chinese brand. The recognizing of Chinese brand's cultural archetype in this paper has constituted the basis of Chinese brand's cultural archetype strategy.Design/methodology/approachBased on the Grounded Theory, this paper has collected and analyzed the value symbols, character images and theme stories of Chinese narrative advertisements and constructed the cultural archetype framework of Chinese brands. This paper makes a comprehensive application of Charmaz's constructivist analysis and the main axis analysis and inspection method advocated by Strauss, with the aim of building a more objective and systematic theoretical framework for the Chinese brand cultural archetype.FindingsIn this framework, it revealed: (1) Chinese brand's cultural archetype can be divided into 12 concrete archetypes according to individual's relationship with self, the other, community and nature; (2) Consumers' different ways of self-categorization are attributed as the essential difference among various archetypes. This paper also compared and analyzed the differences between Chinese and Western cultural archetypes from three perspectives, formation of social structure, pedigree of myth and character's feature.Originality/valueThis paper has certain innovative significance to the theoretical construction of the archetype of Chinese brand culture. First, based on the cultural perspective, this paper applied the cultural psychological connotation of archetype to the brand research across culture, which is more conducive to the researchers' investigation of the cultural psychology of consumers in the cross-cultural context? Second, based on the identification and comparative study of Chinese brand culture archetype, it provides a new expansion and supplement for the research on brand internationalization and globalization in emerging countries.
The King Reports and the common law in South Africa
Authors: Judin J. Michael 
Published: May 2020

Purpose
This paper aims to discuss the King Reports and Codes and the development of South Africa’s common law. The role of developing the common law is explicitly recognised in the Constitution, as is the obligation to give effect to the spirit, purport and objects of the Bill of Rights. With decisions of the Supreme Court of Appeal being based on the King Code, the King Code is now an integral part of South Africa’s common law.

Design/methodology/approach
When the task team drafting King IV commenced their work, one of the important issues raised with Mervyn King, as Chairman, was the challenge to ensure that King IV was aligned to the now firmly entrenched common law principles taken from King I, King II and King III. It is believed that this has been achieved and it is hoped that King IV (and the subsequent King Reports that will inevitably follow because the corporate milieu keeps changing) continues to enrich South Africa’s common law.

Findings
The King Reports and Codes have been made part of South Africa’s common law.

Originality/value
This paper fulfils an identified need to study the King Report and Code, as it relates to South Africa’s common law.
Effect of simulated gastrointestinal digestion of bioactive peptide from pigeon pea (Cajanus cajan) tempe on angiotensin-I converting enzyme inhibitory activity
Authors: Putra Ismail Dwi , Marsono Yustinus , Indrati Retno 
Published: May 2020

Purpose
The purpose of this paper is to understand the effect of hydrolysis by pepsin and pancreatin on the angiotensin-I-converting enzyme (ACE) inhibitory activity of bioactive peptide from pigeon pea tempe and the absorption of pigeon pea tempe peptide by using the everted gut sac method.

Design/methodology/approach
The tempe was prepared by inoculating Raprima (Rhizopus oligosporus) on hulled-cooked pigeon pea for 48 h. The extraction was performed using the ultrasonic method at 40 kHz frequency and 100% ultrasonic power for 10 min. The extracted protein was placed in simulated gastrointestinal digestion using consecutive pepsin–pancreatin for 240 min. The hydrolysates were fractionated using a dialysis tube, and its absorption was assessed using the everted Sprague–Dawley rat gut sac.

Findings
The tempe protein from the hydrolyzed pigeon pea exhibited higher ACE inhibitory (71.53%) activity than that from the boiled pigeon pea (53.04%) (p = 0.028). The bioactive peptide of the digested pigeon pea tempe consisted of low-molecular-weight peptides (<1 kDa). The fraction also showed the highest ACE inhibition activity among the others (IC50 = 0.61 mg/mL, p = 0.021). Bioactive peptides from pigeon pea tempe were absorbed well in the small intestine, mainly in the jejunum. The activity of the absorbed peptides did not change considerably.

Originality/value
The activity of bioactive peptide of pigeon pea tempe was comparatively stable during digestion. It exhibited activity even after absorption in the small intestine. Thus, pigeon pea tempe can serve as an antihypertensive peptide source and alternative food for maintaining/reducing blood pressure.
A role for retinoids in the treatment of COVID‐19?
Authors: Trasino Steven E. 
Published: May 2020

AbstractThe 2020 global outbreak of the novel coronavirus (SARS‐CoV‐2 or COVID‐19) is a serious threat to international health, and thus, there is an urgent need for discovery of novel therapies or use of repurposed drugs that can make a significant impact on slowing the spread of the virus. Type 1 interferons (IFN‐I) are a family cytokines of the early innate immune response to viruses that are being tested against SARS‐CoV‐2. However, coronaviruses similar to SARS‐CoV‐2 can suppress host IFN‐I antiviral responses. Retinoids are a family molecules related to vitamin A that possess robust immune‐modulating properties, including the ability to increase and potentiate the actions of IFN‐I. Therefore, adjuvants such as retinoids, capable of increasing IFN‐I‐mediated antiviral responses, should be tested in combinations of IFN‐I and antiviral drugs in pre‐clinical studies of SARS‐CoV‐2.
Immigration enforcement, crime, and demography
Authors: Chalfin Aaron , Deza Monica 
Published: May 2020

Research SummaryThis research leverages a remarkable natural experiment created by recent legislation in Arizona to study the impact of labor market immigration enforcement on crime. We show that Arizona's Mexican immigrant population decreased by as much as 20% in the wake of the passage of a broad‐based “E‐Verify” law requiring employers to verify the immigration status of new employees. In contrast to previous literature that studied traditional law enforcement‐based immigration enforcement programs such as “Secure Communities,” we find evidence that labor market‐based immigration enforcement led to a decline in some types of crime– particularly property crimes.Policy ImplicationsIt is critical to note that the crime reduction we observe is driven by an unprecedented decline in the share of the immigrant population that is young and male. As such, the effects are purely compositional, suggesting that young immigrant men are no more likely to commit crimes relative to young native men. Given that young immigrant men have high labor market participation and contribute disproportionately to economic output, this research highlights the promise, but also the potentially high costs, of labor market immigration enforcement.
Successful treatment of pyrotinib for bone marrow metastasis induced pancytopenia in a patient with non‐small‐cell lung cancer and ERBB2 mutation
Authors: Wu Yanyan , Ni Jun , Chang Xiaoyan , Zhang Xiaotong , Zhang Li 
Published: May 2020

AbstractERBB2 mutations are found in about 2% of patients with non‐small cell lung cancer (NSCLC). A recent study reported that pyrotinib (an irreversible pan ErbB inhibitor) had superior antitumor effect compared to other tyrosine kinase inhibitor therapies in patients with ERBB2 mutations. Bone marrow metastasis is rare in lung adenocarcinoma, and has been reported to be associated with poor prognosis. Here, we report the case of a 62‐year‐old female diagnosed with lung adenocarcinoma and bone marrow metastasis. ERBB2 exon 20 insertion mutation was confirmed by next‐generation sequencing (NGS) of lung tissue as well as bone marrow. The patient achieved stable disease and recovery of pancytopenia after two months of pyrotinib therapy. This is the first report of homogenous mutations of ERBB2 detected in bone marrow, as well as a good response of bone marrow to pyrotinib therapy.Key points
This is the first report of a homogenous mutation of ERBB2 detected in the bone marrow of an NSCLC patient with bone marrow metastasis.
Our patient with NSCLC ERBB2 mutation and bone marrow metastasis responded well to pyrotinib therapy.
Vascular resection and reconstruction in hilar cholangiocarcinoma
Authors: She Wong Hoi , Cheung Tan To , Ma Ka Wing , Tsang Simon H. Y. , Dai Wing Chiu , Chan Albert C. Y. , Lo Chung Mau 
Published: May 2020

AbstractBackgroundThe aggressive approach of vascular resection plus reconstruction in curative resection of hilar cholangiocarcinoma (HC) remains controversial. This retrospective study investigated its short‐ and long‐term outcomes.MethodsData of HC patients from 1989 to 2016 were reviewed. Operated patients were divided into two groups (with and without vascular resection) and compared in terms of perioperative results. Patients who had unresectable HC were also compared with patients who had been operated.ResultsNinety patients underwent curative HC resection. They were divided into group A (without aggressive approach, n = 68) and group B (with aggressive approach, n = 22). The groups were comparable in all parameters including rates of overall and major complication and in‐hospital, 30‐day and 90‐day mortality except that group B had more patients with more advanced disease (P = 0.008), more patients with tumour invasion of the vasculature (40.9% versus 7.4%, P = 0.001), and fewer patients with blood transfusion (27.3% versus 52.9%, P = 0.036). The groups had similar disease‐free survival (group A: median, 17.9 months, 5 years, 27.4%; group B: median, 11.7 months, 5 years, 14.3%; P = 0.427) and overall survival (group A: median, 22.0 months, 5 years, 26.5%; group B: median, 26.5 months, 5 years, 14.7%; P = 0.90). Two hundred patients with unresectable HC were compared with patients who had received operation and found to have worse survival outcomes (P < 0.001).ConclusionsVascular resection plus reconstruction in HC resection was feasible and safe and might improve the long‐term survival of patients with advanced HC. This aggressive approach should be adopted if the expertise is available and the patient's condition allows.
Gonad development in mature females of tidal spray crab Plagusia depressa (Brachyura: Plagusiidae)
Authors: Guimarães Marcio Paiva , Calado Tereza Cristina dos Santos , de Barros Matheus Souza Ferreira 
Published: May 2020

AbstractInformation on crustacean ovary development is important to properly understand many life story traits. This study aimed to describe macroscopic and microscopic stages of gonad development in females of Plagusia depressa (Fabricius, 1775). Thirty females of P. depressa were captured manually and underwent analgesia by decreasing temperature to collect the gonads, which underwent standard histological techniques. The macroscopic and microscopic appearance of the ovaries and the frequency of germ cells and their location in the organ were used to determine the stage of gonadal development. A total of four stages were defined. Stage 1: marks the end and beginning of gonadal maturation cycle. The germinal zone is tightly reduced with few oogonia and pre‐vitellogenic oocytes are rarely observed. Stage 2: yellow to orange colour and firm consistency. Oogonias and pre‐vitellogenic oocytes can be observed at this stage, as well as a few vitellogenic oocytes at organ limits. Stage 3: colour between red and dark brown. The gonad already presents many mature oocytes. Stage 4: characterized by the abundance of mature oocytes that occupy almost the entire organ. Macroscopic appearance of the female reproductive system, cell characteristics and changes during maturation of P. depressa corroborate with the normally found in Malacostraca.
Venetoclax induces rapid elimination of NPM1 mutant measurable residual disease in combination with low‐intensity chemotherapy in acute myeloid leukaemia
Authors: Tiong Ing S. , Dillon Richard , Ivey Adam , Teh Tse‐Chieh , Nguyen Phillip , Cummings Nicholas , Taussig David C. , Latif Annie‐Louise , Potter Nicola E. , Runglall Manohursingh , Russell Nigel H. , Raj Kavita , Schwarer Anthony P. , Fong Chun Yew , Grigg Andrew P. , Wei Andrew H. 
Published: May 2020

SummaryBased on promising results in older adults with acute myeloid leukaemia (AML), we treated patients with NPM1mut measurable residual disease (MRD) using off‐label venetoclax in combination with low‐dose cytarabine or azacitidine. Twelve consecutive patients were retrospectively identified, including five with molecular persistence and seven with molecular relapse/progression. All patients with molecular persistence achieved durable molecular complete remission (CRMRD‐) without transplantation. Six of seven patients with molecular relapse/progression achieved CRMRD‐ after 1–2 cycles of venetoclax. This paper highlights the promising efficacy of venetoclax‐based therapy to reduce the relapse risk in patients with persistent or rising NPM1mut MRD.
Increased expression of miR142 and miR155 in glial and immune cells after traumatic brain injury may contribute to neuroinflammation via astrocyte activation
Authors: Korotkov Anatoly , Puhakka Noora , Gupta Shalini Das , Vuokila Niina , Broekaart Diede W. M. , Anink Jasper J. , Heiskanen Mette , Karttunen Jenni , van Scheppingen Jackelien , Huitinga Inge , Mills James D. , van Vliet Erwin A. , Pitkänen Asla , Aronica Eleonora 
Published: May 2020

AbstractTraumatic brain injury (TBI) is associated with the pathological activation of immune‐competent cells in the brain, such as astrocytes, microglia and infiltrating immune blood cells, resulting in chronic inflammation and gliosis. This may contribute to the secondary injury after TBI, thus understanding of these processes is crucial for the development of effective treatments of post‐traumatic pathologies. MicroRNAs (miRNAs, miRs) are small noncoding RNAs, functioning as posttranscriptional regulators of gene expression. The increased expression of inflammation‐associated microRNAs miR155 and miR142 has been reported after TBI in rats. However, expression of these miRNAs in the human brain post‐TBI is not studied and their functions are not well understood. Moreover, circulating miR155 and miR142 are candidate biomarkers. Therefore, we characterized miR142 and miR155 expression in the perilesional cortex and plasma of rats that underwent lateral fluid‐percussion injury, a model for TBI and in the human perilesional cortex post‐TBI. We demonstrated higher miR155 and miR142 expression in the perilesional cortex of rats 2 weeks post‐TBI. In plasma, miR155 was associated with proteins and miR142 with extracellular vesicles, however their expression did not change. In the human perilesional cortex miR155 was most prominently expressed by activated astrocytes, whereas miR142 was expressed predominantly by microglia, macrophages and lymphocytes. Pro‐inflammatory medium from macrophage‐like cells stimulated miR155 expression in astrocytes and overexpression of miR142 in these cells further potentiated a pro‐inflammatory state of activated astrocytes. We conclude that miR155 and miR142 promote brain inflammation via astrocyte activation and may be involved in the secondary brain injury after TBI.
Mechanical ventilation for acute respiratory failure due to idiopathic pulmonary fibrosis versus connective tissue disease‐associated interstitial lung disease: Effectiveness and risk factors for death
Authors: Luo Zujin , Yang Liu , Liu Sijie , Hu Yuhan , Cao Zhixin , Zhu Jian , Wang Jing , Ma Yingmin 
Published: May 2020

AbstractIntroductionRelatively little is known about the effects of mechanical ventilation (MV; including invasive MV [IMV] and noninvasive ventilation) on clinical outcomes of patients with idiopathic pulmonary fibrosis (IPF) and connective tissue disease‐associated interstitial lung disease (CTD‐ILD) in the intensive care unit (ICU) and risk factors for ICU death remain to be determined.ObjectivesOur objective was to determine and compare mortality rates between IPF and CTD‐ILD patients receiving MV and to identify risk factors for ICU death in these patients.MethodsWe conducted a retrospective cohort study in respiratory ICUs of three university hospitals in China during a 7‐year period. We compared clinical data and outcomes between patients with IPF and those with CTD‐ILD and performed logistic regression analyses to identify risk factors for ICU death.ResultsOf the 94 patients in the analyses, 63 were diagnosed with IPF and 31 were diagnosed with CTD‐ILD. ICU mortality was significantly higher in the IPF group than in the CTD‐ILD group (86% vs 68%; P = 0.041) and was significantly lower in patients receiving noninvasive ventilation than in those receiving IMV (62% vs 88%; P = 0.004). Risk factors for ICU death were disease progression as the principal cause of acute respiratory failure and IMV.ConclusionBased on current clinical practice in three ICUs, the mortality rate in IPF patients receiving MV might reach 86% and is higher than in CTD‐ILD patients. IMV might be initiated cautiously, especially in patients with disease progression as the principal cause of acute respiratory failure.
Transitions in smoking and nicotine use from 2016 to 2017 among a UK cohort of adult smokers and ex‐smokers
Authors: Simonavicius Erikas , McNeill Ann , Brose Leonie S. 
Published: May 2020

AbstractIntroduction and AimsSmokers differ in how they smoke and how they stop smoking. Use of nicotine replacement therapy (NRT) and e‐cigarettes further diversifies smokers. We aimed to identify and compare latent groups of past‐year smokers and to describe longitudinal transitions between the identified groups.Design and MethodsLatent transition analysis of online UK past‐year smokers' data (n = 2857) collected in June 2016 and followed‐up in October 2017. Latent groups were identified based on participants' smoking, e‐cigarette use, NRT use, urges to smoke and last quit attempt. Sociodemographic and smoking characteristics between the groups were compared using Pearson's χ2 test and Cramer's V.ResultsFour latent groups of smokers (heavy smokers, light smokers, smokers using NRT, smokers using e‐cigarettes) and two recently quit smokers (abstinent ex‐smokers, ex‐smokers using e‐cigarettes) were identified. Nearly half the participants (48.9%) were heavy or light smokers who did not use alternative nicotine products and largely had not tried quitting smoking. Latent groups were relatively stable and transitions to quitting smoking were more probable in groups of smokers using alternative nicotine products. Smokers using NRT transitioned mostly to abstinent ex‐smokers, and smokers using e‐cigarettes to ex‐smokers using e‐cigarettes' groups (11.2% and 11.4%, respectively). The abstinent ex‐smokers group grew the most at follow‐up (+6.3%).Discussion and ConclusionsNearly half of the participants continued smoking without having tried to reduce harm or quit. Of smokers who transitioned, the majority quit smoking and abstained from nicotine altogether. Use of alternative nicotine products alongside smoking was associated with higher probabilities of becoming an ex‐smoker.