bluuebunny/crossref_metadata_2025_split huggingface dataset:
Similarities and Differences between Verbal and Visual Metaphor Processing: an EEG Study
Authors: Ojha Amitash , Ervas Francesca , Gola Elisabetta , Indurkhya Bipin 
Published: December 2019

AbstractThis EEG study explores similarities and differences between verbal and visual metaphor comprehension processes. The results of the study show that interpreting either a verbal stimulus or a visual stimulus metaphorically activates similar brain areas, but there are significant differences between the two in terms of neural connectivity and resource allocation patterns. A greater intra-hemispheric connectivity was observed during verbal metaphor comprehension as compared to greater inter-hemispheric connectivity during visual metaphor comprehension. Results of our novel method, called µ index, suggested a distinct information processing mechanism for metaphor in verbal and visual modalities. We found that metaphorical interpretations, especially highly creative interpretations, of visual stimuli required allocation of greater resources when compared to highly creative interpretations of verbal stimuli. Overall, these results provide a deeper insight into the multimodal nature of metaphor processing.
Inducing Postactivation Potentiation With Different Modes of Exercise
Authors: Ng Choon Yeow , Chen Siow Ee , Lum Danny 
Published: December 2019

ABSTRACT
The use of various modes of exercise to induce postactivation potentiation (PAP) has been studied in the current literature. However, discussion on the advantages and disadvantages of these multiple modes of exercises in inducing PAP within one review study has not been conducted. A brief discussion on the available findings on the effects of different exercises in inducing PAP is presented in this review. Coaches and athletes should take the available information into consideration because the magnitude of PAP effect may vary depending on the mode of exercise performed.
La experiencia estética de la mirada: el ver y oír en la conformación de la palabra tejida en la obra Quipu Mapocho de Cecilia Vicuña
Authors: Bachraty Dagmar Jana 
Published: December 2019

El siguiente artículo tiene por objetivo la discusión frente a la existencia de un lenguaje visual como forma de recuperación de una comunicaciónancestral en el mundo del arte, basada en la experiencia de los sentidos. Es por ello, que se plantea la reminiscencia de una memoria no alfabetizada (ideográfica), táctil, auditiva y visual dentro de la cultura andina, la cual por medio de la plástica moderna y performance de Cecilia Vicuña rememora una antigua función nemotécnica que sustituye a la palabra por una imagen. Es decir, una nueva (o antigua) forma de contar y preservar la memoria histórica latinoamericana. Quipu Mapocho, obra presentada por la artista chilena en el Museo Nacional de Bellas Artes de Chile, 2017, constituye una remembranza como soporte histórico a través del uso de la fotografía y la actualización simbólica de un quipu andino y la imagen de un niño ofrendado en una Capacocha. La palabra en este sentido, se vuelve experiencia, imagen y alegoría.*** A experiência estética do olhar: o ver e o ouvir na conformação da alavra tecida na obra Quipu Mapocho, de Cecilia Vicuña ***O presente artigo busca discutir a existencia de uma linguagem visual como forma de recuperação de uma comunicação ancestral no mundo da arte, a qual é baseada na experiência dos sentidos. É diante disso que se estabelece a reminiscência de uma memoria não alfabetizada (ideológica), táctil, auditiva e visual dentro da cultura andina, a qual, por meio de um trabalho plástico e performático de Cecília Vicuña, rememora-se uma antiga função mnemónica que substitui a palavra por uma imagem. Esta é uma nova (ou antiga) forma de contar e preservar a memoria histórica latino-americana. Quipu Mapocho, obra apresentada pela artista chilena no Museu Nacional de Bellas Artes no Chile em 2017, constitui uma lembrança como suporte histórico por meio do uso da fotografía e da atualização simbólica de um quipu andino e a imagen de um menino como uma oferenda à Capacocha. A palabra, nesse contexto, torna-se uma experiencia, uma imagen e uma alegoria. PALAVRAS-CHAVE: Experiência; Quipu Mapocho; Cacilia Viaiña; Imagens históricas
Real-Space Approach for the Electronic Calculation of Twisted Bilayer Graphene Using the Orthogonal Polynomial Technique
Authors: Le Hoang Anh , Nguyen Van Thuong , Nguyen Van Duy , Do Van-Nam , Ho Si Ta 
Published: December 2019

We discuss technical issues involving the implementation of a computational method for the electronic structure of material systems of arbitrary atomic arrangement. The method is based on the analysis of time evolution of electron states in the real lattice space. The Chebyshev polynomials of the first kind are used to approximate the time evolution operator. We demonstrate that the developed method is powerful and efficient since the computational scaling law is linear. We invoked the method to study the electronic properties of special twisted bilayer graphene whose atomic structure is quasi-crystalline. We show the density of states of an electron in this graphene system as well as the variation of the associated time auto-correlation function. We find the fluctuation of electron density on the lattice nodes forming a typical pattern closely related to the typical atomic pattern of the quasi-crystalline bilayer graphene configuration.
Molecular Analyses of Left- and Right-Sided Tumors in Adolescents and Young Adults with Colorectal Cancer
Authors: Salem Mohamed E. , Battaglin Francesca , Goldberg Richard M. , Puccini Alberto , Shields Anthony F. , Arguello David , Korn W. Michael , Marshall John L. , Grothey Axel , Lenz Heinz-Josef 
Published: December 2019

Abstract

Background
The incidence of colorectal cancer (CRC), particularly left-sided tumors (LT), in adolescents and young adults (AYA) is rising. Epigenetic events appear to play an important role in tumorigenesis and cancer progression, especially in younger patients. We compared molecular features of LT to right-sided tumors (RT) in AYA.

Materials and Methods
A total of 246 LT and 56 RT were identified in a cohort of 612 AYA with primary CRC. Tumors were examined by next-generation sequencing (NGS), protein expression, and gene amplification. Tumor mutational burden (TMB) and microsatellite instability (MSI) were determined based on NGS data.

Results
RT showed higher mutation rates compared with LT in several genes including BRAF (10.3% vs. 2.8%), KRAS (64.1% vs. 45.5%), PIK3CA (27% vs. 11.2%), and RNF43 (24.2% vs. 2.9%). Notably, additional mutations in distinct genes involved in histone modification and chromatin remodeling, as well as genes associated with DNA repair and cancer-predisposing syndromes, were characteristic of RT; most frequently KMT2D (27.8% vs. 3.4%), ARID1A (53.3% vs. 21.4%), MSH6 (11.1% vs. 2.3%), MLH1 (10.5% vs. 2.3%), MSH2 (10.5% vs. 1.2%), POLE (5.9% vs. 0.6%), PTEN (10.8% vs. 2.3%), and BRCA1 (5.4% vs. 0.6%). MSI was seen in 20.8% of RT versus 4.8% of LT. RT had a higher frequency of TMB-high regardless of MSI status.

Conclusion
Molecular profiling of AYA CRC revealed different molecular characteristics in RT versus LT. Epigenetic mechanisms and alteration in DNA repair genes warrant further investigation and may be a promising treatment target for CRC in AYA.

Implications for Practice
Colorectal cancer (CRC) in adolescents and young adults (AYA) comprises a distinct entity with different clinicopathologic features and prognosis compared with older patients. Molecular profiling of right- and left-sided tumors in AYA is needed to gain novel insight into CRC biology and to tailor targeted treatment in this age group. This study found that right- and left-sided CRC show distinct molecular features in AYA, overall and in subgroups based on microsatellite instability status. Alterations in DNA double-strand break repair and homologous recombination repair, as well as epigenetic mechanisms, appear to play a critical role. The present molecular profiling data may support the development of personalized treatment strategies in the AYA population.
Anti-cancer activity of сuraxin CBL0137 on the models of acute leukemia in vitro
Authors: Fetisov T. I. , Kirsanov K. I. , Borunova A. A. , Zatsepina M. N. , Lesovaya E. A. , Zabotina T. N. , Belitsky G. A. , Yakubovskaya M. G. 
Published: December 2019

Background. Curaxin CBL0137 is a novel non-genotoxic compound with anti-cancer activity based on CBL0137 ability of non-covalent interaction with DNA causing histone chaperone FACT relocation. Anti-cancer activity of this drug was demonstrated previously on the wide panel of solid cancer models in vitro and in vivo.Objectives. Estimation of anticancer effects of CBL0137 on the acute myeloblastic leukemia cells (THP-1) and acute lymphoblastic leukemia (CCRF-CEM).Materials and methods. CBL0137 cytotoxicity was analyzed using the MTT test, the effects on the cell cycle and the induction of apoptosis was assessed by flow cytometry, the activity of signaling pathways in cells treated with CBL0137 was determined by real-time polymerase chain reaction.Results. Cell treatment with CBL0137 led to cell cycle arrest and apoptosis induction. In the study of CBL0137 effect on target gene clusters of 10 signal transduction pathways involved in the pathogenesis of acute leukemia we have showed that CBL0137 inhibited the expression of down-stream genes of WNT and Hedgehog signaling in both cell lines. In THP-1 cells we also observed the inhibition of the expression of PPARγ target and hypoxia-activated genes. In CCRF-CEM cells CBL0137 also induced the expression of Notch signaling target genes.Conclusion. The antitumor activity of CBL0137 was demonstrated on acute leukemia cell cultures, the drug possesses cytotoxicity, causes cell cycle arrest and activation of apoptosis. Significant changes in the expression of efferent gene clusters of several signaling pathways were observed in the cells treated with CBL0137.
New approaches in 3D modeling of in vitro growth of primary cultures of malignant gliomas
Authors: Khochenkova Yu. A. , Dyrda I. G. , Machkova Yu. S. , Solomko E. Sh. , Sidorova T. A. , Khochenkov D. A. , Avilova E. A. 
Published: December 2019

Background. The incidence of brain gliomas firmly occupies a leading position among all central nervous system tumors – 40–50 % of the cases detected, more than half of them are glioblastoma. Existing cell lines and cultivation methods do not reflect all the features of the three-dimensional (3D) organization of native glioblastoma. The use of temozolomide leads to the development of drug resistance and acute relapse, followed by a poor clinical outcome. The development of resistance is largely associated with the presence of tumor stem cells in the population and intratumoral heterogeneity. Obtaining 3D cultures from the primary material will allow us to save the stem cell pool and tumor-specific features.The study objective. Get a 3D model based on primary cell cultures, which allows you to save a heterogeneous population and the original phenotype of tumor cells.Materials and methods. We used U-87MG human glioma cells and GBM002 primary cell culture obtained from surgical material with a confirmed diagnosis of glioblastoma. Neurospheres were obtained from cell lines, the growth of which was monitored using the InCell Analyzer 6000 automatic cell analysis system. Flow cytometry was used to determine the CD133+ cell content. The expression of the receptor tyrosine kinases VEGFR1, VEGFR2 (endothelial growth factor type 1 and 2 receptors), FGFR2 (fibroblast growth factor receptor type 2) and the hypoxia marker HIF-1α (hypoxia inducible factor, 1α) in the neurospheres was evaluated using confocal microscopy.Results. GBM002 glioblastoma cells isolated from the surgical material formed neurospheres, while the number of CD133+ cells increased from 1–2 to 16–19 % compared with two-dimensional cultures. During long-term cultivation of cells with non-cytotoxic doses of temozolomide, it was found that such cells form smaller neurospheres compared to control cells. It was shown that the expression of receptor tyrosine kinases during cultivation of GBM002 glioblastoma cells in neurospheres differs from that in two-dimensional cultures. We found that in neurospheres, the expression of FGFR2 and VEGFR1, is significantly increased.Conclusion. 3D cultivation of primary cultures allows one to obtain a more heterogeneous population of tumor cells that reflects the spatial heterogeneity of cells, increase the pool of stem cells and recreate hypoxia conditions inside the brain micro-tumors.
Imágenes urológicas ITU por cuerpo extraño vesical
Authors: Ruiz Murga Javier , Tresierra Alegre C. , Santa María Barreto R. 
Published: December 2019

Tres pacientes de (a) 52 años, (b) 60 años y (c) 42 años de edad intervenidos hace 5 años, 3 años y 2 años respectivamente de incontinencia urinaria de esfuerzo mediante la intervención de Burch vía abdominal.A partir de los 2, 3 y 1.5 meses respectivamente inician infecciones del tracto urinario (ITU) a repetición, manejados por médicos generales y/o ginecólogos con tratamiento antibióticos previos urocultivos y antibiogramas.
The Monitoring of Fungal Contamination in Indoor Air of Two Hospitals in Shiraz
Authors: Abbasi Fariba , Jalili Mahrokh , Samaei Mohammad Reza , Mokhtari Ali Mohammad , Azizi Elahe 
Published: December 2019

Introduction: Hospitals, as one of the important elements in the health system, play an important role in patient’s health. Fungi are one of the effective parameters on indoor air quality. This study aimed to compare of fungal contamination of two hospitals in Shiraz City.
Materials and Methods: Sampling was conducted based on NIOSH 0800 standard (1.5 meters above the ground level with one stage Anderson and Sabaroud dextrose agar enriched chloramphenicol as the growth media) in January-September 2017. The investigated wards included pathological laboratory, emergency rooms, neonatal specialist care, radiology, operating room, and maternity ward. The results showed that the variation and concentration of fungi were higher in hospital X than hospital Y, which was located in an agricultural area far from the city center.
Results: The predominant fungi were Monillia, Aspergillus, and Penicillium in hospital Y, while they were Aspergillus and Penicillium in hospital X. The highest concentrations were found in emergency and laboratory wards. With regard to higher fungal contamination of hospital X and its different location, it can be concluded that the geographical properties and outdoor air are effective factors on indoor air contamination at hospitals.
Conclusion: Appropriate management of patients' admission and visiting time can be effective on indoor air contamination at hospitals. Furthermore, efficient ventilation using high-efficiency particulate air and appropriate devices for elimination of fungi level are recommended to this end. Moreover, these parameters can provide physical and psychometric health problems for patients’ careers and other health workers.
Sustainability Impact Assessment of Waste to Energy Technologies in Iran
Authors: Teimouri Fahimeh , Teimouri Fahimeh , Ebrahimi Ali Asghar , Jalili Mahrokh , Alaghehbandan Hamid Reza 
Published: December 2019

Introduction: Current energy sources are coming to end and one of the main priorities of the country’s management is the energy recovery from renewable energy. Considerable quantity of municipal solid waste (MSW) is one of the most serious urban pollution sources. Impact assessment matrix is a new and fast tool for Environmental Impact Assessment (EIA).
Materials and Methods: In this regard, renewable energy like waste-to-energy was investigated. Environmental assessment method was performed to evaluate the environmental impacts of common Waste to Energy (WTE) technologies by Wooten and Rau matrix. Most available WTE technologies (anaerobic digestion, sanitary landfill with gas recovery, waste incineration, and gasification) were environmentally assessed and compared.
Results: Results showed that anaerobic digestion could be most environmental friendly WTE technology for production of renewable energy from organic waste and could be considered. Furthermore, executives as green minded managements can improve the quality of waste management by finding new solutions. Other technologies such as landfill by gas recovery and gasification will be ranked second and third in terms of environmental effect.
Conclusion: Results showed that performing anaerobic digestion technology will produce less environmental impact in long term. Then landfilling by gas recovery and gasification technologies will be ranked second and third in terms of environmental effect.
Prevalence of Oral Mucosal Lesions in Admitted Patients in Yazd Shahid Sadoughi Hospital in 2018
Authors: Owlia Fatemeh , Tabatabaei Hossein , Motallaei Mohammad Nima , Ayatollahy Reza 
Published: December 2019

Introdution: One of the most important signs of general health is oral health. Many systemic diseases have oral manifestations that could be appeared in the oral cavity at first. Therefore, considering the importance of timely diagnosis and treatment of oral lesions. This study was conducted to determine the prevalence of oral lesions in the patients admitted to Yazd ShahidSadoughi Hospital.
Methods: In this cross sectional study, 443 hospitalized patients were clinically evaluated for oral mucosal lesions. All of the abnormal variations in oral mucosa in these patients, demographic data, type & location of oral lesion, existence of denture & smoking were documented. Data were analyzed by SPSS Inc., Chicago, IL; Version 19 was analyzed using Chi-square and Fisher exact tests.
Results: Oral lesions were observed in 37.7% of patients. The most common type of lesion was related to red and white lesions, which was seen in 19.1% of patients. Palate was the common location for red and white lesions. Most of vesiculobollous lesions were observed in the hard palate and tongue. The lesions rate increased with aging. Among the lesions, only pigmented lesions were significantly higher in males.
Conclusion: Regarding the high prevalence of oral mucosal lesions in admitted patients, the importance of more attention to oral cavity for timely diagnosis and referral in the routine examination is emphasized.
Sustentabilidade e gestão do conhecimento
Authors: Souto Leonardo Fernandes , Pizzol Rosa Amélia 
Published: December 2019

Analisam-se, com foco no tema sustentabilidade, os documentos publicados nos anais eletrônicos do KM Brasil, correspondente às treze edições do evento, no período de 2002 a 2016. Tem-se por objetivo identificar a amplitude do tema sustentabilidade, o perfil de autoria e a diversidade temática, no âmbito das discussões relacionadas à gestão do conhecimento, a partir da base histórica do KM Brasil, o maior evento do tema na América Latina. A fundamentação teórica apresenta breve caracterização sobre gestão do conhecimento e sustentabilidade. O estudo descritivo caracteriza-se por uma abordagem quanti-qualitativa, com utilização das técnicas da bibliometria, sobretudo, por meio de estatística descritiva, complementada por uma análise de conteúdo. A análise quantitativa abrangeu, inicialmente, 605 documentos, concentrando-se, posteriormente, nos 18 artigos que apresentaram o tema sustentabilidade no título e/ou nas palavras-chave, sendo a análise qualitativa restrita somente a estes 18 artigos. Dentre os resultados, destaca-se a ocorrência de 54 autores que publicaram sobre o tema sustentabilidade, com prevalência de autoria do gênero masculino, coletiva, com vínculo acadêmico e atuação no setor público; além de terem sido identificados 42 assuntos e 18 focos relacionados à sustentabilidade e à gestão do conhecimento. Conclui-se se evidenciando que, apesar do grande número de participantes atuantes no mercado empresarial, há uma considerável predominância da academia na realização dos estudos sobre sustentabilidade e que a quantidade de 18 documentos sobre sustentabilidade é pouco representativa diante do total das 605 publicações que fazem parte da base histórica do KM Brasil.
Fan Identification, Brand Community Identification, and Oppositional Brand Loyalty towards Sponsors of a Rival Sports Team: The Mediating Role of Schadenfreude
Authors: AMANI DAVID 
Published: December 2019

Empirical evidence confirms that brand loyalty is broadly understood in the context of positive side i.e. supportive loyalty compared to negative side i.e. oppositional loyalty. However, theoretically positive (supportive) loyalty cannot be explained exclusively without considering negative (oppositional) loyalty. This study, therefore, examines brand loyalty using a triadic approach combining both negative and positive loyalty in the cycle of love and hate relationship. Specifically, the study examined the influence of fan and brand community identification on oppositional brand loyalty towards sponsors of a rival team in sports industry. A survey cross-sectional research design was adopted, through collecting data using semi-structured questionnaire from 228 highly identified fans of two giant sports teams in Tanzania namely Simba Sports Club and Young Africans Sports Club. The collected data were analyzed using Structural Equation Modelling (SEM), and findings revealed that fan and brand community identification have a strong positive significant influence on oppositional brand loyalty towards sponsors of a rival team when mediated with schadenfreude. Therefore, business firms should take precautions when embarking on sponsorship of highly competing sports teams. Finally, this study adopted a quantitative approach, hence further studies that adopt a qualitative approach is recommended to get a naturalistic picture of subject under the study. Additionally, a comparative study is recommended to compare level of resistance loyalty exhibited by fans of each team.
SOCIAL IDENTITY EXPRESSIONS IN KEVIN KWAN’S CRAZY RICH ASIANS
Authors: Ifada Nailul , Mufidah Zakiyatul 
Published: December 2019

The study deals with the expression of social identity in Asians elite community circle found in the novel Crazy Rich Asians by Kevin Kwan. Primary data regarding social identity expressions are noted based on the characters’ utterances and author’s narration found in the novel. The study is categorized as qualitative research as the data are displayed in the form of words from the novel’s original language. The methods of collecting data used by the writer are reading and labeling. The writer acts as the mere observer without other instruments included. Data analysis method includes compiling, disassembling, reassembling, interpreting and concluding based on Robert K. Yin’s techniques of analyzing data. The results indicate that there are a number of social identity expressions in Kwan’s Crazy Rich Asians. There are two significant ways of expressing social identity of the rich: (1) the patterns of consumption including food, fashion, and personal luxury belongings. (2) social image maintenance through early education, interaction, special occasion and club membership.