bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comentarios editoriales: duplicación, redundancia y ética en las publicaciones médicas
Authors: Pérez Romero Germán Enrique 
Published: April 2020

A raíz de la reciente publicación del trabajo de Rodríguez J, Prieto S, Ortiz L, Bautista A, Bernal P, Vargas N. Diagnóstico matemático de la monitoría fetal. Aplicando la Ley de Zipf-Mandelbrot; en el número 2 del volumen 54 de nuestra revista1 y la simultánea aparición en la Revista Colombiana de Obstetricia y Ginecología de: Rodríguez J, Prieto S, Ortiz L, Bautista A, Álvarez L, Correa C, Avilán N. Diagnóstico matemático de la monitoría fetal con la Ley de Zipf-Mandelbrot y la teoría de los sistemas dinámicos aplicados a la fisiología cardíaca; el editor desea precisar como es costumbre en las revistas médicas que:31.-Todo trabajo científico recibido para evaluación del comité editorial, se acompaña de una carta firmada por todos los autores donde se establece que el manuscrito no ha sido presentado a otra revista.2.-El proceso de revisión por pares es anónimo y que durante él se mantiene comunicación con los autores a fin de corregir, adicionar o ampliar los conceptos contenidos en el trabajo analizado.3.-Una vez aceptado para publicación, los autores reciben notificación de la fecha probable de publicación (volumen y año). La amplia homología de las publicaciones mencionadas y en especial de la metodología utilizada, los grupos de pacientes y las conclusiones, permiten aseverar que se trata de una publicación redundante.
Utilidad clínica del estudio anatomopatológico de la placenta en el Hospital Universitario San Vicente de Paúl
Authors: Cortés Hernán , Muñoz Henry 
Published: April 2020

Objetivos: caracterizarlos hallazgos placentarios en relación con la patología materna o fetal y conocer el porcentaje de hallazgos patológicos en las muestras enviadas para estudio.Materiales y métodos: estudio descriptivo retrospectivo realizado en el Hospital Universitario San Vicente de Paúl. Se incluyeron todas las placentas a las que se les realizó estudio histológico en los últimos tres años (2003-2005); se revisaron todas las historias de las pacientes a quienes se les realizó el estudio, estableciendo el diagnóstico histológico y el motivo por el que fueron enviadas a patología (complicación materna o fetal).Resultados: se revisaron 60 placentas, de estas 19 (31,6%) se reportaron como normales. Las características más prevalentes fueron los cambios isquémicos y la amnionitis; en los casos de síndrome hipertensivo asociado al embarazo (SHAE) y retardo del crecimiento intrauterino (RCIU) el hallazgo más frecuente fueron los cambios isquémicos; en ruptura prematura de membranas (RPM), sífilis y parto prematuro fue la amnionitis. No se reportó ningún hallazgo en los casos de malformación fetal.Conclusiones: solo se enviaron a patología el 1% de las placentas. Se encontraron hallazgos significativos solo en el 68% de las placentas en comparación con lo reportado en otras series, donde se encuentran alteraciones patológicas importantes en el 92% de estas. Se debe alentar el envío a patología de las placentas con anormalidades macroscópicas y aquellas con indicaciones maternas y fetales para aumentar la posibilidad de encontrar hallazgos relevantes.
DETERMINAN SOLVABILITAS DANA TABARRU’ PADA PERUSAHAAN ASURANSI SYARIAH DI INDONESIA
Authors: Lestari Iis Indah , Mukhibad Hasan 
Published: April 2020

<p><strong><em>Abstract</em></strong></p><p><em>Solvency of tabarru’ funds can indicate a company's ability to pay obligations Islamic insurance claims payments to the participants or policyholders. Related to this, the Financial Services Authority has set a minimum limit of solvency margin tabarru’ funds which amounted to 30% which must be fulfilled by Islamic insurance companies. However, there are three Islamic insurance companies that have a solvency tabarru’ funds under the terms of at least 30%, such as PT Asuransi Astra Buana, Takaful Protection Jaya and PT Tugu Pratama Indonesia. The purpose of this study was to determine the effect of firm size, type of company, Retakaful premiums, investment, wealth available to qardh, and operating expenses to fund solvency tabarru on Islamic insurance company in Indonesia. The population in this study </em><em>was</em><em> Islamic insurance company over registered at the Financial Services Authority (OJK) in the year 2013-2018. By using purposive sampling techniques, sample end of the study amounted to 14 mining companies with 84 units of analysis. Meanwhile, </em><em>the </em><em>analysis us</em><em>ed </em><em>descriptive statistical analysis and panel regression analysis with Eviews 9. The results showed that the return on investment and wealth available to qardh positive and significant impact on the solvency of tabarru’ fund. Variable size of company, type of company, Retakaful premiums, and operating expenses partially </em><em>have </em><em>no effect on the solvency of the tabarru’ fund. </em></p>
Self-Regulated Learning Microanalysis For The Study Of The Performance Of Clinical Examinations By Physiotherapy Students
Authors: Medina Raquel , Álamo-Arce Daniel David , de Castro Felipe Rodríguez , Fernandez Dario Cecilio , Sandars John , Costa Manuel João 
Published: April 2020

Abstract
Background Students require feedback on their self-regulated learning (SRL) processes to improve the performance of clinical examinations. The key SRL processes used by students can be identified by SRL-micro-analysis but, this method has not been previously applied to physiotherapy students. The aim of this pilot study was to test a research design that might allow the evaluation of the potential usefulness of SRL microanalysis for the identification of key SRL processes used by physiotherapy students during the performance of a clinical examination skill.. The objectives of the pilot study were: 1) to evaluate whether SRL-microanalysis could identify differences in the use of SRL processes between successful and unsuccessful students; 2) to evaluate the reliability of SRL microanalysis ratings produced by different assessors.Methods SRL-microanalysis was used with second year physiotherapy students of a Spanish university (n= 26) as they performed a goniometric task. The task required students to obtain a goniometric measurement of the shoulder joint of a peer. Two assessors evaluated student performance and conducted the SRL- microanalysis with all students. An analysis of inter-rater reliability was performed to evaluate the degree of agreement between assessors. Results The SRL-microanalysis revealed differences in the use of key SRL processes between successful (n= 15: 57.0%) and unsuccessful performers (n= 11: 43.0%): The differences were particularly evident in strategic planning and self-monitoring skills. There was good inter-rater reliability for scoring of strategic planning (k=0.792), self-monitoring (k=0.946) and self-evaluation (k=0.846).Conclusion The use of SRL microanalysis characterized the key SRL processes of physiotherapy students performing a clinical skill with reliability between the assessors. This pilot study supports the potential usefulness of SRL-microanalysis for the identification of key SRL processes in physiotherapy education. Therefore, this study paves the way to the development of a full study, with a larger number of students and more diverse clinical tasks, to evaluate the SRL processes in successful and unsuccessful students.
Smokeless tobacco use: its prevalence and relationships with dental symptoms, nutritional status and blood pressure among rural women in Burkina Faso
Authors: Diendéré Jeoffray , Zeba Augustin Nawidimbasba , Nikiéma Leon , Kaboré Ahmed , Savadogo Paul Windinpsidi , Tougouma Somnoma Jean Baptiste , Tinto Halidou , Ouédraogo Arouna 
Published: April 2020

Abstract
Background: Sub-Saharan women use smokeless tobacco (SLT) more than smoked tobacco. Among Western African countries, the estimated weighted prevalence of SLT use in rural women was found to be the highest in Burkina Faso (after Sierra Leone). This study aimed to assess the prevalence of SLT use and its associated factors among rural women in Burkina Faso by using nationally representative data.Methods: We used data from the 2013 STEPwise approach to Surveillance (STEPS) study, which provided sociodemographic, clinical (anthropometric, systolic blood pressure [SBP], diastolic blood pressure [DBP] and dental symptoms), biological (total and high-density lipoprotein cholesterol and fasting blood sugar), and tobacco and alcohol consumption data. Data for 1730 rural women were used, and we performed Student’s chi-squared and logistic regression analyses.Results: The prevalence of current SLT use was 13.8% (95% CI: 12.2-15.5). Significant risks for SLT use were the presence of dental symptoms (adjusted odds ratio [aOR] = 2.59; p<0.001), undernourishment (aOR = 1.78; p<0.01), decreased waist circumference (aOR = 0.98; p<0.05), decreased DBP (aOR = 0.97; p<0.01), increased SBP (aOR = 1.01; p<0.05), and increased differential blood pressure (aOR = 1.01; p<0.05). The co-use of alcohol was also a significant risk factor (aOR = 2.80; p<0.001).Conclusion: The prevalence of current SLT use was high among rural women in Burkina Faso, and significant concerns for users included alcohol co-use, the occurrence of dental symptoms, undernourishment, and an increase in differential blood pressure. National Public Health interventions are needed to reduce SLT use and its health-related concerns.
The influence of balanced complex chromosomal rearrangements on preimplantation embryonic development potential and molecular karyotype
Authors: Li Gang , Shi Weiyi , Niu Wenbin , Xu Jiawei , Guo Yihong , Su Yingchun , Sun Yingpu 
Published: April 2020

Abstract
Background: Balanced complex chromosome rearrangements (BCCR) are balanced chromosomal structural aberrations that involve two or more chromosomes and at least three breakpoints. It is very rare in the population.The objective is to explore the difference of influence of three types of BCCR on early embryonic development and molecular karyotype.Results:Twelve couples were recruited including four couples of three-way rearrangements carriers (group A), three couples of double two-way translocations carriers (group B) and five couples of exceptional CCR carriers (group C). A total of 243 oocytes were retrievedin the seventeen preimplantation genetic testing (PGT) cycles, and 207 of these were available for fertilization.After intracytoplasmic sperm injection, 181oocytes normally fertilized. The rates of embryos forming on day3 in three groups were 87.88%, 97.78% and77.14%, which was significantly different (P=0.01). Compared with group B, the rate of embryo formation was statistically significantly lower in group C(P=0.01).Furthermore, the rates of high-quality blastocysts in three group were 14.71%, 48.15% and 62.96%, respectively, which was significantly different (P=0.00). Compared with group B andC, the rate of high-quality blastocysts in group A was statistically significantly lower (P=0.00;P=0.00). Comprehensive chromosome analysis was performed on 83 embryos, including 75 trophectodermcellsand 8 blastomeres. Except 7 embryos failed to amplify, 9.01%embryos were diagnosed as euploidy, and 90.91% were diagnosed as abnormal. As for group A, the euploid embryo rate was 10.71%and the abnormal embryo rate was 89.29%. In group B,the euploid embryo rate was 3.85%, the abnormal embryo rate was 96.15%. The euploid embryo rate was 13.04%, the abnormal embryo rate was 86.96% in group C.There were no significant differences among the three groups (P = 0.55).Conclusions:The lowest rate of high quality blastocysts has been for three-way rearrangements and the lowest rate of euploidy has been for double two-way translocations, although no significant difference. Different types of BCCR maybe have little effect on the embryonic molecular karyotype. The difference of influence of BCCR on early embryonic developmentandmolecular karyotypeshould be further studied.
Lonely places or lonely people? Investigating the relationship between loneliness and place of residence
Authors: Victor Christina R , Pikhartova Jitka 
Published: April 2020

Abstract
Background: Loneliness in later life is largely presented as a problem of the individual focusing upon antecedents such as demographic or health factors. Research examining the role of the broader living environments is much rarer. We examined the relationship between loneliness and three dimensions of the lived environment: geographical region, deprivation, and area classification (urban or rural).Methods: Our sample consisted of 4,663 core members (44% males) aged 50+ (wave 7 mean age 72.8, S.D.= 7.1) present both in waves 3 (2006) and 7 (2014) of the English Longitudinal Study of Ageing (ELSA). Loneliness was measured using two approaches, individual and area-based, and both waves included these questions. Individual-based (self-reported) loneliness was assessed using the three item University of California Los Angeles (UCLA) scale (ranging from 3 =not lonely to 9= lonely with a score of 6+ defining loneliness. We also used a novel question which asked participants to evaluate how often they felt lonely in their area of residence (area-based; ranging from 1=often to 7=never, using cut off 4+ to define loneliness). The lived environment was classified in three different ways: the Index of Multiple Deprivation (IMD), Government Office Regions (GOR), and area classification (urban or rural). Covariates with established relationship with loneliness including demographic factors, social engagement and health, were included in the analyses. Results: In wave 7, the prevalence of individual-based loneliness was 18% and area-based was 25%. There was limited congruence between measures: 68% participants reported no individual- or area-based loneliness and 9% reported loneliness for both measures. After adjusting for individual co-variates only one significant relationship was observed between loneliness and area -based characteristics. A significant association was observed between area-based loneliness and deprivation score, with higher levels of loneliness in more deprived areas (OR=1.4 for highest quintile of deprivation). Conclusions: Our results indicate that loneliness in older adults is higher in the most deprived areas independent of individual-level factors. In order to develop appropriate interventions further research is required to investigate how area-level factors combine with individual-level loneliness vulnerability measures to generate increased levels of loneliness in deprived areas.
Different profiles of body mass index variation among patients with multidrug-resistant tuberculosis: a retrospective cohort study.
Authors: Diallo Alhassane , Diallo Boubacar Djelo , Camara Lansana Mady , Kounoudji Lucrèce Ahouéfa Nadège , Bah Boubacar , N’Zabintawali Fulgence , Carlos-Bolumbu Miguel , Diallo Mamadou Hassimiou , Sow Oumou Younoussa 
Published: April 2020

Abstract
Background: Despite the predictive role of body weight variation in treatment outcome in multidrug-resistant tuberculosis (MDR-TB), few corroborating data are available. We studied weight variation in patients with MDR-TB to identify groups of weight change and to determine factors that influence these changes. Methods: We analyzed patients with rifampicin resistance who were treated with an MDR-TB treatment regimen between June 07, 2016 and June 22, 2018 at three major drug-resistant TB centers in Guinea. Patients were seen monthly until the end of treatment. Clinical outcome was the body mass index (BMI). We used a linear mixed model to analyze trajectories of BMI and a latent class mixed model to identify groups of BMI trajectories. Results: Of 232 patients treated for MDR-TB during the study period, 165 were analyzed. These patients had a total of 1387 visits, with a median of 5 visits (interquartile range, 3 – 8 visits). Monthly BMI increase was 0.24 (SE 0.02) per kg/m 2 . Factors associated with faster BMI progression were success of MDR-TB treatment (0.24 [SE 0.09] per kg/m 2 ; p = 0.0205) and absence of lung cavities on X-ray (0.18 [0.06] per kg/m 2 ; p = 0.0068). Two groups of BMI change were identified: rapid BMI increase (n = 121; 85%) and slow BMI increase (n = 22; 15%). Patients in the slow BMI increase group were mostly female (68%) had no history of TB treatment (41%), had a positive HIV infection (59%), and had a more severe clinical condition at baseline, characterized by a higher frequency of symptoms including depression (18%), dyspnea (68%), poor adherence to MDR-TB treatment (64%), lower platelet count, and higher SGOT. These patients also had a longer time to initial culture conversion (log-rank test: p = 0.0087). Conclusion: Quantitative BMI data on patients with MDR-TB treated with a short regimen allowed the identification of subgroups of patients with different trajectories of BMI and emphasized the usefulness of BMI as a biomarker for the monitoring of MDR-TB treatment outcome.
Caregiver Burden is Reduced by Personalized Social Support for Non-Dependent Old Persons: a Longitudinal Study of 876 Old Persons and Their Caregivers
Authors: Arlotto Sylvie , Gentile Stéphanie , Durand Anne Claire , Bonin-Guillaume Sylvie 
Published: April 2020

Abstract
Background. Informal care provided by family caregivers to old persons is associated with a high risk of burden and poor health status. This study aimed to analyze the impact of Personalized Social Support (PSS) for non-dependent old persons living in the community on caregiver burden, satisfaction, and frailty. Methods. This non-interventional longitudinal study was performed in the southeast of France: old persons asking for PSS (>70 years of age, with no disability and no severe chronic disease, living at home) and their caregivers were included with a 6-month follow-up. Eligible dyads were visited at home by social workers. Caregiver burden was assessed with Mini-Zarit and frailty status with FiND (Frail Non-Disabled).Results. 876 dyads were eligible for PSS. Old persons were 82.2 ± 5.8 years old and 77.6% were women. Most caregivers were women (64.5%). Most caregivers were the children of the old person (61%), the rest were mostly spouses. Nearly 64% of old persons were frail and 38% were highly dependent. Follow-up was conducted for 686 dyads (78.3%). Of these, only 569 had PSS. The PSS was mainly for housework and meal preparation. At the time of follow-up, 53% of the caregivers for whom the old person had PSS had less difficulty helping their old person. Two-thirds (61.5%) of caregivers were fully satisfied with the PSS. Whether or not they had received the PSS, 73% of caregivers had reduced burden at 6 months, only 6% still had a high burden, 17% were less frail, and 18% felt healthier than at the time of inclusion.Conclusions. Our study highlights that non-dependent old person’s caregivers also experience burden. Implementing social support for activities of daily living had a major impact on their burden but not on their level of frailty. This means that the determinants of caregiver frailty are more complex and further studies are needed.
Relationship between Internet addiction and sleep disturbance in high school students: a cross-sectional study
Authors: Tokiya Mikiko , Itani Osamu , Otsuka Yuichiro , Kaneita Yoshitaka 
Published: April 2020

Abstract
Background: Worldwide, the increase in the number of Internet users has increased Internet dependence. In adolescents, this dependence interferes with sleep, which is important for the development of psychophysiological capabilities. However, few large-scale surveys have descriptively examined the relationship between Internet addiction (IA) and sleep disturbance using standardized questionnaires. We conducted this study to determine the relationship between sleep disturbance in adolescents and IA based on the categories of the Young Diagnostic Questionnaire (YDQ) through a complete survey of one prefecture in Japan. Methods: In 2016, a self-report questionnaire was used to survey high school students (n=10,405, age range: 15–16 years) in all 54 day-boarding high schools in the selected prefecture. We defined “sleep disturbance” by scores greater than 5.5 points on the Japanese version of the Pittsburgh Sleep Quality Index. IA was evaluated using the YDQ: “IA,” when 5 of the 8 YDQ items were present; “at-risk,” when either 3 or 4 YDQ items were reported; and “non-IA,” when less than 2 YDQ items were positive. Multiple logistic regression analysis was undertaken with sleep disturbance as the dependent variable, IA as the explanatory variable, and adjustments for 8 items. Results: High YDQ scores were associated with high prevalence rates of sleep disturbance in both male and female participants. These findings persisted after controlling for other factors in the multiple regression model. Conclusions: Among Japanese adolescents, there exists a significant independent relationship between IA and sleep disturbances.
Prevalence, antimicrobial susceptibility patterns, serotypes and risk factors for group B streptococcus rectovaginal isolates among pregnant women at Kenyatta National Hospital, Kenya; A cross-sectional study
Authors: Salano Jisuvei Clayton , Alfred Osoti , Njeri Maina Anne 
Published: April 2020

Abstract
Background Estimates of group B streptococcus ( GBS) disease burden, antimicrobial susceptibility, and serotypes in pregnant women are limited for many resource-limited countries including Kenya. These data are required to inform recommendations for prophylaxis and treatment of infections due to GBS. Methods We evaluated the prevalence, antimicrobial susceptibility patterns, serotypes, and risk factors associated with rectovaginal GBS colonization among pregnant women receiving antenatal care at Kenyatta National Hospital (KNH) between August and November 2017. Consenting pregnant women between 12 and 40 weeks of gestation were enrolled. Interview-administered questionnaires were used to assess risk factors associated with GBS colonization. An anorectal swab and a lower vaginal swab were collected and cultured on Granada agar for GBS isolation. Positive colonies were tested for antimicrobial susceptibility to penicillin G, ampicillin, vancomycin, and clindamycin using the disk diffusion method. Serotyping was performed by latex agglutination. Logistic regression was used to identify factors associated with GBS colonization. Results A total of 292 women were enrolled. Median age was 30 years (Interquatile range {IQR} 26-35) with a median gestational age of 35 weeks (IQR 30-37). Overall GBS was identified in 60/292 (20.5%) of participants. Among the positive isolates, resistance was detected for penicillin G in 42/58 (72.4%) isolates, ampicillin in 32/58 (55.2%) isolates, clindamycin in 14/46 (30.4%) isolates, and vancomycin in 14/58 (24.1%) isolates. All ten GBS serotypes were isolated, and 37/53 (69.8%) of GBS positive participants were colonized by more than one serotype. None of the risk factors was associated with GBS colonization. Conclusion The prevalence of GBS colonization was high among mothers attending antenatal clinic at KNH. In addition, a high proportion of GBS isolates were resistant to commonly prescribed intrapartum antibiotics. Hence, other measures like GBS vaccination is a potentially useful approaches to GBS prevention and control in this population. Screening of pregnant mothers for GBS colonization should be introduced and antimicrobial susceptibility test performed on GBS positive samples to guide antibiotic prophylaxis.
Synthesis and biological evaluation of 4-substituted aryl-piperazine derivatives of 1,7,8,9-tetrachloro-10,10-dimethoxy-4-azatricyclo [5.2.1.02,6] dec-8-ene-3,5-dione as anti-cancer and anti-angiogenesis agents
Authors: Guo Lifang , Xu Benshan , Wan Zirui , Ren Lulu , Zhang Jie , Zhang Wen , Liu He , Liu Lihong 
Published: April 2020

Abstract
The authors have requested that this preprint be removed from Research Square.