bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kinetic Studies of Photopolymerization of Monomer‐Containing Deep Eutectic Solvents
Authors: Fazende Kylee F. , Gary Daniel P. , Mota‐Morales Josué D. , Pojman John A. 
Published: February 2020

AbstractThe kinetics of photopolymerization in deep eutectic solvents (DESs) is investigated through real‐time Fourier transform‐infrared spectrometry (RT‐FTIR). The systems of this study are choline chloride (ChCl) DESs made of acrylic acid and methacrylic acid (DES monomers) and a nonreactive analog isobutyric acid (IBA). The DES consisting of the analog also contains the monomer methyl methacrylate (MMA). Analysis of the evolution of conversion indicates dramatic increase in polymerization rate when comparing the polymerization of the DES monomers to pure monomer polymerization. A significant increase in polymerization rate is also seen in the systems that include a methyl ester derivative of the hydrogen bond donor monomer (e.g., MMA) in a nonpolymerizable DES (e.g., IBA−ChCl). It is proposed that the increased solvent viscosity, preorganization due to hydrogen bonding, and the polarity of the DES around the monomers play a role in the enhancement of the polymerization rate.
Arm Dimensions of Patients with Obesity and Their Experiences with Blood Pressure Measurement: An Observational Study
Authors: Ceglowski Peter , Lehane Katie , Chow Christopher , Pelecanos Anita , Tognolini Angela , Eley Victoria 
Published: February 2020

ObjectiveIn patients with obesity, it was determined what proportion had an arm slant angle (SA) < 83° and which measure best predicted arm conicity. Patient experience with noninvasive blood pressure measurement was evaluated.MethodsArm SA was calculated from arm measurements. Linear regression determined whether BMI, weight, or right midarm circumference (MAC) best predicted conicity. Patient experiences were evaluated by survey and conventional content analysis of free‐text comments.ResultsOne hundred participants had a median (interquartile range; range) BMI of 44.1 (39.1‐53.1; 31.1‐80.8). Thirty‐three (33%) had a right arm SA < 83°. Seven (7%) had a right MAC outside the recommended range. BMI, weight, and the right MAC showed low correlation with and explained little of the variation (with age and sex adjustment) in right arm SA (r = −0.29, −0.27, −0.31; P = 0.003, 0.007, 0.002; R2 = 0.09, 0.08, 0.10). Forty‐two (42%) reported noninvasive blood pressure measurement caused severe pain, and 30 (30%) reported skin damage. Themes identified in free‐text responses were “problems with equipment,” “feelings and experiences,” and “concerns about accuracy.”ConclusionsCurrent equipment is inadequate for patients with obesity based on MAC and conicity. Pain and skin damage contributed to negative experiences of these patients.
Halogenation of the N‐Terminus Tyrosine 10 Promotes Supramolecular Stabilization of the Amyloid‐β Sequence 7–12
Authors: Maiolo Daniele , Pizzi Andrea , Gori Alessandro , Gazzera Lara , Demitri Nicola , Genoni Alessandro , Baggi Fulvio , Moda Fabio , Terraneo Giancarlo , Baldelli Bombelli Francesca , Metrangolo Pierangelo , Resnati Giuseppe 
Published: February 2020

AbstractHere, we demonstrate that introduction of halogen atoms at the tyrosine 10 phenol ring of the DSGYEV sequence derived from the flexible amyloid‐β N‐terminus, promotes its self‐assembly in the solid state. In particular, we report the crystal structures of two halogen‐modified sequences, which we found to be stabilized in the solid state by halogen‐mediated interactions. The structural study is corroborated by Non‐Covalent Interaction (NCI) analysis. Our results prove that selective halogenation of an amino acid enhances the supramolecular organization of otherwise unstructured biologically‐relevant sequences. This method may develop as a general strategy for stabilizing highly polymorphic peptide regions.
Physical problem list accompanying the distress thermometer: Its associations with psychological symptoms and survival in patients with metastatic lung cancer
Authors: McFarland Daniel C. , Jutagir Devika R. , Miller Andrew , Nelson Christian 
Published: February 2020

AbstractBackgroundThe distress thermometer and problem list (DT&PL) is a recommended screening measure but the utility of the physical problem list (PPL) has not been evaluated in patients with metastatic lung cancer who typically have high rates of both physical and psychological symptoms. We hypothesized that the PPL will provide an accurate representation of lung cancer symptoms and be associated with concomitant distress, anxiety, depression, and worsened survival.MethodsStage IV lung cancer patients (n = 116) reported physical symptoms from 22 PPL variables and completed the DT&PL for distress, general anxiety disorder‐7 for anxiety, and Patient Health Questionnaire 9 for depression. Inferential analyses were controlled for demographic and clinical characteristics.ResultsThe average number of physical problems was 4.7 (SD = 3.8) while the median was 3.0. Fatigue, sleep, pain, and breathing problems were most common. Physical symptom burden was associated with nonmarried/partnered status (P = .003) and depression (P < .001) on multivariate analysis accounting for 43% of physical symptom burden variance. Greater number of physical symptoms and lower BMI were associated with worsened survival. Individual physical symptoms were most often associated with depression.ConclusionThe PPL of the DT&PL appears to have clinical utility given its associations with the most common lung cancer symptoms, depression, and worsened survival. In addition to its potential role in clinics worldwide already using the DT&PL, physical symptom burden on the DT&PL should trigger a concomitant psychological assessment.
Achieving robotic program best practice performance and cost versus laparoscopy: Two case studies define a framework for optimization
Authors: Feldstein Josh , Coussons Herbert 
Published: February 2020

AbstractBackgroundRobotic surgery is seen by many hospital administrators and surgeons as slower and more expensive than laparoscopic surgery despite the implementation of commonly held robotic best practices. Multiple factors, including surgeon learning curves and program governance, are often overlooked, precluding optimal robotic program performance.MethodsAn assessment of several leading robotic surgery publications is presented followed by real‐world case studies from two US hospitals: an existing robotic program in a mid‐sized, regional hospital system and a small, rural hospital that launched a new program.ResultsImprovements in robotic surgery costs/program efficiency were seen at the hospital system vs baseline at 18 months post‐implementation; and high‐performance robotic efficiency and cost benchmarks were matched or surpassed at the rural hospital at 1 year post‐launch.DiscussionWhen best practices are utilized in robotic programs, surgical case times, costs, and efficiency performance metrics equaling or exceeding laparoscopy can be achieved.
Healthcare software design and implementation—A project failure case
Authors: Ebad Shouki A. 
Published: February 2020

SummaryElectronic health records (EHRs) are implemented by many health care organizations as a potential service solution. Despite the appeal of EHRs, failure in their implementation can lead to negative consequences, ranging from the loss of money to reputation damage, for health care providers. However, the causes of this problem have not attracted the attention of a sufficient number of researchers. This paper aims to investigate this phenomenon objectively and subjectively in a public context using an interview‐based qualitative approach supported by archival data and records of a real‐world failed EHR project. The results show that the factors influencing failure are divergent and include technical and managerial issues. In particular, the timing and duration of the training as well as the integration of EHR with the enterprise systems were found to be the strongest influencing factors, followed by reasons related to the software design (eg, a lack of required pharmacy functionality) and software people management (eg, resistance to change). The paper also discusses points related to EHR development and design, such as the development paradigm, data quality and validation, architecture for security, and source code naming convention.
Wind interference effects of a ventilated supertall building on its neighboring supertall building—A case study
Authors: Liang Ruoran , Xu An , Zhao Ruohong 
Published: February 2020

SummaryOpening ventilating holes on a supertall building is an effective way to reduce its wind‐induced structural response and enhance its wind‐resistant performance. However, its interference effect on the neighboring supertall buildings has seldom been studied yet. Taking two actual neighboring buildings, the Guangdong International Financial Center (IFC) and the Guangzhou Chow Tai Fook Finance Centre (CTF) as examples, this study carried out high‐frequency force balance wind tunnel tests to investigate the interference effect of the IFC's ventilating openings on the wind‐induced response of CTF. Results show that when CTF is located in the downstream area of IFC, the ventilating openings on IFC make the high‐energy frequency band of the power spectral density (PSD) of CTF's crosswind aerodynamic load offset obviously towards the lower frequency interval. Consequently, the wind‐induced response of CTF can be significantly magnified or minified depending on the reduced structural natural frequencies. Since the reduced natural frequency for the structural base bending moment computation is usually smaller than that for the acceleration response computation, ventilation openings on IFC can be advantageous to the crosswind base bending moment response relevant to structural safety design, and disadvantageous to the acceleration response relevant to occupant comfort assessment.
Aerobic exercise and eugenol supplementation ameliorated liver injury induced by chlorpyrifos via modulation acetylcholinesterase activation and antioxidant defense
Authors: Nikbin Sina , Tajik Atefeh , Allahyari Pooneh , Matin Gity , Hoseini Roote Seyede S. , Barati Elahe , Ayazi Mehras , Karimi Leila , Dayani Yazdi Fatemeh , Javadinejad Nassrin , Azarbayjani Mohammad A. 
Published: February 2020

AbstractThe primary metabolize of chlorpyrifos (CPF) is in the liver tissue, which it can cause oxidative damage and apoptosis in liver cells. The use of exercise with antioxidant supplements could have a protective effects in the liver tissue especially by improve mitochondria function. The aim of the present study was to investigate the protective effect of aerobic exercise and eugenol (Eu) supplementation on destructive effects of CPF in liver tissue. Sixty‐four adult male albino rats were randomly divided into eight groups (eight rats in each group). Four experimental groups received intraperitoneal injection of either 3.0 mg/kg body weight CPF in dimethyl sulfoxide for six consecutive weeks. Aerobic exercise was performed 5 days per week over 4 weeks for exercise groups. Finally, the animals were sacrificed for the histomorphometric analysis and biochemical measurement in the liver tissue. The result of this study show that consumption of CPF alone, caused collagen deposition, increased apoptosis, tumor necrosis factor α, malondialdehyde, and decreased catalase, superoxide dismutase, acetylcholinesterase (AChE) compared to control and exercise groups (healthy groups) in liver tissue (P ˂ .05). Prescription of exercises and Eu supplements in CPF consumer groups, neutralized this destructive effects of CPF. However, concomitant administration of Eu with exercise had better effects on liver tissue (P ˂ .05). It seems that consumption of Eu with aerobic exercise have a protective role in tissue destruction, inflammatory damage by improving antioxidant defense and modulating AChE activity in hepatocytes.
Validation of radiological reduction criteria with intraoperative cone beam CT in unstable syndesmotic injuries
Authors: Vetter Sven Yves , Euler Jeannie , Beisemann Nils , Swartman Benedict , Keil Holger , Grützner Paul Alfred , Franke Jochen 
Published: February 2020

Abstract
Purpose
Acute unstable syndesmotic lesions are regularly treated with closed or open reduction and fixation with either a positioning screw or tight rope. Conventional fluoroscopy is limited to identify a malreduction of the ankle mortise. The aim of the study was to validate the reduction criteria of intraoperative cone beam CT in unstable syndesmotic injuries by analyzing the clinical outcome.

Methods
Acute unstable syndesmotic injuries were treated with a positioning screw fixation, and the reduction in the ankle mortise was evaluated with intraoperative cone beam CT. The patients were grouped postoperatively according to the radiological reduction criteria in the intraoperative 3D images. The reduction criteria were unknown to the surgeons. Malreduction was assumed if one or more reduction criteria were not fulfilled.

Results
Seventy-three of the 127 patients could be included in the study (follow-up rate 57.5%). For 41 patients (56.2%), a radiological optimal reduction was achieved (Group 1), and in 32 patients (43.8%) a radiological adverse reduction was found (Group 2). Group 1 scored significantly higher in the Olerud/Molander score (92.44 ± 10.73 vs. 65.47 ± 28.77) (p = 0.003), revealed a significantly higher range of motion (ROM) (53.44 vs. 24.17°) (p = 0.001) and a significantly reduced Kellgren/Lawrence osteoarthritis score (1.24 vs. 1.79) (p = 0.029). The linear regression analysis revealed a correlation for the two groups with the values scored in the Olerud/Molander score (p < 0.01).

Conclusion
The reduction criteria in intraoperative cone beam CT applied to unstable syndesmotic injuries could be validated. Patients with an anatomic reduced acute unstable syndesmotic injury according to the criteria have a significantly better clinical outcome.
Genauigkeit der konventionellen Röntgendiagnostik bei der Beurteilung der Daumensattelgelenkarthrose
Authors: Erne H. , Moog P. , Cerny M. , Loew S. , Betzl J. , Machens H.-G. , Schmauss D. 
Published: February 2020

Zusammenfassung
Hintergrund
Die Daumensattelgelenkarthrose ist ein häufiges und schmerzhaftes Krankheitsbild, das mittels konventioneller Röntgenbildgebung und Arthroskopie diagnostiziert und ggf. therapiert werden kann. Dabei stellt die Röntgenklassifikation oft den arthroskopisch dargestellten Knorpelschaden nicht angemessen dar.

Ziel der Arbeit (Fragestellung)
Das Ziel dieser Arbeit war, die Genauigkeit von konventioneller Röntgendiagnostik im Vergleich zu Arthroskopie bei Daumensattelgelenkarthrose zu beurteilen.

Material und Methoden
Die präoperativen konventionellen Röntgenbilder von 23 Patienten wurden 10 erfahrenen Handchirurgen vorgelegt, die gegenüber den dazugehörigen Arthroskopiebefunden verblindet waren. Ihre Beurteilungen wurden anschließend mit den Befunden der Arthroskopien verglichen.

Ergebnisse
Elf Patienten wiesen Läsionen 4. Grades nach der Outerbridge-Klassifikation auf, 8 Läsionen 3. Grades, 4 Läsionen 2. Grades und keiner Läsionen 1. Grades. Insgesamt wurden 43 % (95 %-KI[Konfidenzintervall] 37–49 %) der Knorpelläsionen mittels konventionellen Röntgens korrekt diagnostiziert. Für die Läsionen 4. Grades stellten 73 % (95 %-KI 65–81 %) der Untersucher korrekte Diagnosen, für die 3. Grades 38 % (95 %-KI 27–49 %) und für die 2. Grades 13 % (95 %-KI 3–23 %).

Schlussfolgerung
Diese Studie präsentiert ein arthroskopisches Klassifikationssystem, das spezifisch für die Daumensattelgelenkarthrose ist und eine weitere Beurteilungsmöglichkeit darstellen kann, falls die Bilder für die röntgenologischen Klassifikation nach Eaton und Littler zu unspezifisch sind. Hier kann die Arthroskopie eine genauere Einteilung in therapierelevante Stadien ermöglichen und umfasst zudem auch therapeutische Optionen.
A Relaxed Kačanov iteration for the p-poisson problem
Authors: Diening L. , Fornasier M. , Tomasi R. , Wank M. 
Published: February 2020

AbstractIn this paper we introduce and analyze an iteratively re-weighted algorithm, that allows to approximate the weak solution of the p-Poisson problem for $$1 < p \leqslant 2$$1<p⩽2 by iteratively solving a sequence of linear elliptic problems. The algorithm can be interpreted as a relaxed Kačanov iteration, as so-called in the specific literature of the numerical solution of quasi-linear equations. The main contribution of the paper is proving that the algorithm converges at least with an algebraic rate.
Acetabular defects in revision hip arthroplasty: a therapy-oriented classification
Authors: Wirtz Dieter Christian , Jaenisch Max , Osterhaus Thiemo Antonius , Gathen Martin , Wimmer Matthias , Randau Thomas Martin , Schildberg Frank Alexander , Rössler Philip Peter 
Published: February 2020

Abstract
Introduction
The treatment of severe acetabular bone loss remains a difficult challenge. No classification system is available that combines intuitive use, structured design and offers a therapeutic recommendation according to the current literature and modern state of the art treatment options. The goal of this study is to introduce an intuitive, reproducible and reliable guideline for the evaluation and treatment of acetabular defects.

Methods
The proposed Acetabular Defect Classification (ADC) is based on the integrity of the acetabular rim and supporting structures. It consists of 4 main types of defects ascending in severity and subdivisions narrowing down-defect location. Type 1 presents an intact acetabular rim, type 2 includes a noncontained defect of the acetabular rim ≤ 10 mm, in type 3 the rim defect exceeds 10 mm and type 4 includes different kinds of pelvic discontinuity. A collective of 207 preoperative radiographs were graded according to ADC and correlated with intraoperative findings. Additionally, a randomized sample of 80 patients was graded according to ADC by 5 observers to account for inter- and intra-rater reliability.

Results
We evaluated the agreement of preoperative, radiographic grading and intraoperative findings presenting with a k value of 0.74. Interobserver agreement presented with a k value of 0.62 and intraobserver at a k value of 0.78.

Conclusion
The ADC offers an intuitive, reliable and reproducible classification system. It guides the surgeon pre- and intraoperatively through a complex field of practice.
Exponential Stability for the Schlögl System by Pyragas Feedback
Authors: Gugat Martin , Mateos Mariano , Tröltzsch Fredi 
Published: February 2020

AbstractThe Schlögl system is governed by a nonlinear reaction-diffusion partial differential equation with a cubic nonlinearity. In this paper, feedback laws of Pyragas-type are presented that stabilize the system in a periodic state with a given period and given boundary traces. We consider the system both with boundary feedback laws of Pyragas type and distributed feedback laws of Pyragas and classical type. Stabilization to periodic orbits is important for medical applications that concern Parkinson’s disease. The exponential stability of the closed loop system with respect to the L2-norm is proved. Numerical examples are provided.
Scratch Card Near-Miss Outcomes Increase the Urge to Gamble, but Do Not Impact Further Gambling Behaviour: A Pre-registered Replication and Extension
Authors: Stange Madison , Dixon Mike J. 
Published: February 2020

AbstractScratch card near-misses, outcomes in which two out of three required jackpot symbols are uncovered, have been shown to erroneously increase the urge to continue gambling. It remains unknown if and how these outcomes influence further gambling behaviour. Previous studies examining the influence of near-misses on purchasing behaviour offered a low-stakes gamble to participants after experiencing a near-miss or a regular loss. We sought to investigate the influence of these outcomes on scratch card purchasing behaviour with a stronger test of participants’ gambling behavior by having them either “cash out” or risk all of their winnings to purchase another card. Additionally, we sought to test an original hypothesis that endorsement of the illusion of control might influence the decision to purchase additional scratch cards. We pre-registered our hypotheses, sample size, and data analysis plan. 138 subjects experienced two custom-made scratch card games that included a win on the first card (for all participants) and either a regular loss or a near-miss in the final outcome position on the second card (between-subjects manipulation). Although near-miss outcomes increased the urge to continue gambling relative to regular losses, no differences in the rates of purchasing were found between the conditions. Additionally, no support for our hypotheses concerning the influence of the illusion of control in near-miss outcomes was found. These results are discussed in terms of previous studies on scratch card gambling behaviour and subjective reactivity.
Verletzungen des Akromioklavikulargelenks
Authors: Tauber Mark , Hradecky Katarina , Martetschläger Frank 
Published: February 2020

ZusammenfassungIn den letzten Jahren haben sich neue Aspekte in der Behandlung des Schultereckgelenks eröffnet, welche sich in der Klassifikation, Diagnostik und Indikationsstellung akuter Verletzungen niederschlagen. Insbesondere die horizontale Instabilität rückte dabei in den Fokus der Wissenschaft und fand Berücksichtigung sowohl in der bildgebenden Diagnostik als auch in der Erstellung neuer Klassifikationssysteme und operativen Stabilisierungstechniken. Inwieweit dies im Versorgungsalltag von klinischer Relevanz sein wird, müssen hochwertige Studien in Zukunft aufzeigen. Als Standardbildgebung gelten eine Panoramaaufnahme mit Belastung sowie eine bilaterale Alexander-Aufnahme. Hinsichtlich Operationsindikation gelten weiterhin höhergradige Verletzungsformen Typ IV–VI als klare Indikation, während Typ I–III konservativ behandelt werden sollte. Biomechanische Daten sprechen für eine so anatomisch wie mögliche Versorgung mit Adressierung sowohl der vertikalen als auch horizontalen Instabilität.
Applied precision cancer medicine in metastatic biliary tract cancer
Authors: Taghizadeh H. , Müllauer L. , Mader R. , Prager G. W. 
Published: February 2020

Abstract
Introduction
Advanced therapy-refractory biliary tract cancer (BTC) has poor prognosis and constitutes a major challenge for adequate treatment strategies. By mapping the molecular profiles of advanced BTC patients, precision cancer medicine may provide targeted therapies for these patients.

Objective
In this analysis, we aimed to show the potential of PCM in metastatic BTC.

Methods
In this single-center, real-world retrospective analysis of our PCM platform, we describe the molecular profiling of 30 patients diagnosed with different types of metastatic BTC. Tumor samples of the patients were examined using a 161-gene next-generation sequencing panel, immunohistochemistry (IHC), and fluorescence in situ hybridization for chromosomal translocations.

Results
In total, we identified 35 molecular aberrations in 30 patients. The predominant mutations were KRAS (n = 8), TP53 (n = 7), IDH2 (n = 4), and IDH1 (n = 3) that accounted for the majority of all molecular alterations (62.86%). BRAF mutations were observed in two patients. Less frequent alterations were noted in ARID1A, CTNNB1, ESR1, FBXW7, FGFR2, MET, NOTCH2, PIK3CA, PTCH1, SMAD4, and SRC1, each in one case. FGFR fusion gene was detected in one patient. No mutations were detected in eight patients. IHC revealed EGFR and p-mTOR expression in 28 patients. Applying these results to our patients, targeted therapy was recommended for 60% of the patients (n = 18). One patient achieved stable disease.

Conclusions
PCM is a feasible treatment approach and may provide molecular-guided therapy recommendations for metastatic BTC.