bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inframammary Fold Approach for Second-stage Operation in Expander—Implant Breast Reconstruction
Authors: Min Kyunghyun , Jeon Dong Nyeok , Han Hyun Ho , Kim Eun Key , Eom Jin Sup 
Published: December 2020

Background and Objectives
Despite expander-based breast reconstruction being used as a reliable reconstruction method, implant removal due to wound dehiscence and infection still occurs in 0.5% to 15% of cases. This study aimed to compare the outcomes of the new inframammary fold (IMF) incision approach with previous incision in second-stage operation of expander-based 2-stage breast reconstruction.

Methods
Patients who underwent expander-based 2-stage breast reconstruction between February 2014 and May 2019 were included. After expander inflation, patients undergoing second-stage reconstruction were divided into the previous incision and IMF incision groups and their outcomes were compared. Propensity score matching analysis was performed to compare postoperative 1-year results.

Results
The previous incision and IMF incision groups comprised 79 and 31 patients, respectively. There were no intergroup differences in general demographics or intraoperative data, except for total inflation volume (426.87 ± 102.63 mL in the previous incision group and 375.48 ± 94.10 mL in the IMF incision group, P = 0.017). Wound dehiscence occurred in 12 and 0 cases in the previous and IMF incision groups, respectively (P = 0.018). Implant removal was performed due to dehiscence in 9 cases (8.18%) and 0 cases (0%) in the previous and IMF incision groups, respectively (P = 0.049). In 1-to-1 propensity score matching analysis, the IMF incision group showed better results at 1-year follow-up (odds ratio: 0, 95% confidence interval: 0–1.09; P = 0.063).

Conclusions
The IMF approach is a safe method for replacing the expander with an implant, with lower incidence of wound dehiscence and implant explantation.
Long-Term Photogrammetric- and Panel Assessment‐Based Outcome Study of Staged Reconstructive Approach for Hypertelorism Correction
Authors: Chuang Kai-Ti , Denadai Rafael , Yong Jin-Han , Chou Pang-Yun , Chen Yu-Ray 
Published: December 2020

Background
The surgical management of hypertelorism is challenging for plastic surgeons, and limited long-term outcome data are available. The purpose of this long-term study was to report a single-surgeon experience with a staged reconstructive protocol for hypertelorism correction.

Methods
This retrospective study reviewed the records of patients with hypertelorism who were surgically managed by a single surgeon between 1978 and 2000. Bone (orbital box osteotomy and orthognathic surgery) and soft tissue (rhinoplasty and epicanthoplasty) surgeries were performed based on a patient-specific surgical protocol. Included patients were divided into a childhood group and an adolescence or adulthood group according to their age at orbital repositioning (≤12 and >12 years, respectively). Patients were invited for clinical interviews in February 2020 to evaluate whether requests for revision surgery had been made. The photogrammetric analysis–based hypertelorism index was calculated at preoperative and long-term postoperative times. Satisfaction with the long-term outcome was judged by both surgical professionals and laypeople.

Results
In total, 14 patients with hypertelorism of different etiologies were included, with no request for revision surgery during an average follow-up of 29 years. The preoperative hypertelorism index was higher than the long-term postoperative evaluation (all, P < 0.05) for both childhood and adolescence or adulthood groups. Intergroup comparison revealed no significant difference for the hypertelorism index and panel assessment–based satisfaction with long-term outcome analysis (all, P > 0.05).

Conclusions
Considering the complexity and wide spectrum of clinical presentation of soft tissue and bone deformities in hypertelorism and current outcomes, the surgical approach to these patients should be staged and individualized for achievement of a balanced result between functional (orbital, occlusion, and psychosocial) and aesthetic parameters.
Flap Repair Technique for Soft Tissue Defects of the Hand
Authors: Zhao Fengjing 
Published: December 2020

Abstract
Repair for the soft tissue defects of hand has been a major challenge of hand or reconstructive surgery. A lot of flaps are used, free or pedicle flap, but there are no comprehensive description of these flaps. In this article, we retrospectively reviewed the repair technique of the fingertip defect, palmar or dorsal defect of the hand, by using different flaps in 14 cases, between June 2010 and December 2014, and the advantages and limitation of each flap are simply stated. We have shown a lot of surgical pictures, with a small amount of text, providing a wide range of ideas for the surgeon to freely choose an easy and effective method for his own technology. Overall, these approaches are simple, safe, and effective for repairing the soft tissue defect of the hand.
Bisphosphonate-Related Osteonecrosis of the Jaw
Authors: Chien Hsin-I , Chen Lee-Wei , Liu Wen-Chung , Lin Cheng-Ta , Ho Yen-Yi , Tsai Wei-Hsuan , Yang Kuo-Chung 
Published: December 2020

Objectives
Antiresorptive agents for bone pain were widely used to treat patients with advanced osteoporosis, multiple myeloma, and bone metastatic cancer. In recent years, however, bisphosphonate-related osteonecrosis of the jaw (BRONJ) has been a rare but major complication of this therapy. Most patients with BRONJ undergo dental procedures during treatment with antiresorptive agents. However, BRONJ may also occur spontaneously. This study reports 13 BRONJ patient cases at Kaohsiung Veterans General Hospital, Taiwan, and their related treatments. We also compare patients with cancer with patients with osteoporosis in treatment outcomes.

Methods
Thirteen symptomatic patients with BRONJ were reviewed between 1985 and 2018 at Kaohsiung Veterans General Hospital. We included patients at advanced stage who were hospitalized for infection control of osteonecrosis of the jaw and excluded asymptomatic patients at stage 0 and stage 1. Four multiple myeloma, 3 patients with bone metastatic breast cancer and 6 patients with advanced osteoporosis (average ages, 63.57 ± 14.54 years in cancer patients and 79.5 ± 9.31 years in osteoporosis patients; average drug durations, 25.86 ± 27.23 months in cancer patients and 58.33 ± 23.87 months in osteoporosis patients; average follow-up times, 22.71 ± 14.46 months in cancer patients and 28.08 ± 36.35 months in osteoporosis patients) were included.

Results
Seven patients were defined as having stage 3 (53.8%) and 6 as having stage 2 (46.2%) medication-related osteonecrosis of the jaw, according to the American Association of Oral and Maxillofacial Surgeons classification. The complete response rate with totally healed mucosa was 61.5%. Four cancer patients received free fibular flap (FFF) reconstruction with a high complete response rate (100%). All of them had a relatively better performance status, and the average age was also younger than osteoporosis patients.

Conclusion
Free fibular flap with a high complete response rate may improve pain relief and infection control for patients with BRONJ. Younger age is seemed to be a great indicator for FFF, but poor self-care ability (Eastern Cooperative Oncology Group status >3) is not suitable for these surgical treatments.
Are Backyard Waterslides as Dangerous as Public Waterslides: A Review of 1,823 Head and Neck Injuries
Authors: Lee Kevin C. , Stanbouly Dani , Chuang Sung-Kiang 
Published: December 2020

Abstract
The purpose of this study was to describe the characteristics and compare the severity of head and neck injuries between public and backyard waterslides. This was a 20-year cross-sectional study of the National Electronic Injury Surveillance System. Injuries from waterslides were included in this study if they involved the head, face, eyeball, mouth, neck, or ear. Patient and injury characteristics were compared by the type of waterslide using chi-squared and independent sample tests. A total of 1823 injury reports were identified (39.8% backyard waterslides and 60.2% public waterslides). The mean age at the time of injury was 13.2 years, and the majority of patients were white (74.2%) males (55.1%). The most common primary diagnoses were laceration (28.4%) and internal organ injury (27.2%). A greater proportion of backyard injuries involved the head (P < 0.01) and resulted in concussions (P < 0.01) or fractures (P = 0.04). The overall admission rate from the ED was 3.5%, and no fatalities were noted. There were no significant differences in admission rates between injuries from backyard and public slides. Fatal or serious head and neck injuries appear to be uncommon with waterslide injuries. Backyard waterslides pose a greater likelihood of cranial injury, and this may relate to differences in riding habits between public and private waterslides.
Accessory Cranial Suture Leading to Abnormal Head Shape
Authors: Leach Garrison A. , Kurnik Nicole M. , Bristol Ruth E. , Singh Davinder J. 
Published: December 2020

Abstract
Accessory cranial sutures have been described in the literature and are most commonly associated with the parietal bone. These sutures are typically identified incidentally and there have been no reported cases of accessory cranial sutures leading to abnormal head shape.
The authors present the case of a 3-month-old patient with multiple congenital anomalies and an accessory parietal suture leading to abnormal head shape. The patient was successfully treated with cranial orthotic therapy. To our knowledge, this is the first reported case of an accessory cranial suture leading to abnormal head shape.
HIF-1α and Hypoxia Responsive Genes are Differentially Expressed in Leukocytes From Survivors and Non-Survivors Patients During Clinical Sepsis
Authors: Ferreira Bianca Lima , Leite Giuseppe Gianini Figueirêdo , Brunialti Milena Karina Colo , Assuncao Murillo , Azevedo Luciano Cesar Pontes , Freitas Flávio , Salomao Reinaldo 
Published: December 2020

ABSTRACT
Hypoxia inducible factor 1 alpha (HIF-1α) is linked to the metabolic and immune alterations in septic patients. Stabilization of HIF-1α by hypoxia or inflammation promotes the expression of several genes related to glycolytic metabolism, angiogenesis, coagulation, cell proliferation, and apoptosis. Here, we analyzed public available blood transcriptome datasets from septic patients and evaluated by PCR array the expression of HIF-1α and other hypoxia responsive genes in peripheral blood mononuclear cells from patients with sepsis secondary to community acquired infections. Samples were collected at intensive care unit admission (D0, n=29) and after 7 days follow-up (D7, n = 18); healthy volunteers (n = 10) were included as controls. Hypoxia and glycolysis were among the top scored molecular signatures in the transcriptome datasets. PCR array showed that 24 out of 78 analyzed genes were modulated in septic patients compared with healthy volunteers; most of them (23/24) were downregulated at admission. This same pattern was observed in surviving patients, while non-survivors presented more upregulated genes. EGLN1, EGLN2, and HIF1AN, inhibitors of HIF-1α activation were downregulated in patients, regardless of the outcome, while HIF-1α and other target genes, such as PDK1 and HMOX1, expression were higher in non-survivors than in survivors, mainly at D7. Non-survivor patients also presented a higher SOFA score and lower PaO2/FiO2 ratio. Our results indicate a differential modulation of hypoxia pathway in leukocytes between septic patients who survived and those who did not survive with an increased intensity at D7, which is possibly influenced by disease severity and may affect the immune response in sepsis.
Umbilical Hernia Repair in Cirrhotic Patients With Ascites: A Systemic Review of Literature
Authors: Guo Chenchen , Liu Quanguo , Wang Yong , Li Junsheng 
Published: December 2020

Background:
Umbilical hernia is a common abdominal complication in cirrhotic patients. The incidence of umbilical hernias can be up to 20% in the presence of ascites. However, there is no consensus regarding the optimal management of umbilical hernias in cirrhotic patients. The purpose of this study is to review the management of umbilical hernias in cirrhotic patients with ascites.

Methods:
A search of the available literature in English since 1980 was performed using PubMed, the Cochrane Library, and a search of relevant journals and reference lists. The search terms included “umbilical hernia,” “ascites,” “cirrhosis,” and any derivatives of these terms, and the literature search identified all the relevant publications.

Results:
Thirty-three relevant articles published in the language of English were identified. Fourteen studies involved the management of refractory ascites in cirrhotic patients. Twenty-four studies included cirrhotic patients receiving elective or emergency surgery. Because of much lower morbidity and mortality in elective surgery than in emergency surgery, many authors advocated early elective repair of uncomplicated umbilical hernias in cirrhotic patients. Of these, 2 studies described laparoscopic umbilical hernioplasty, with a significant lower morbidity and hernia recurrence than open repair. Fifteen studies described the use of prosthetic mesh umbilical hernia repair in cirrhotic patients, which was associated with minimal wound-related morbidity and markedly lower recurrences.

Conclusions:
Our results indicate that early elective repair of uncomplicated umbilical hernias is recommended in cirrhotic patients with tolerable hepatic functional reserve or when the expected time for liver transplantation is >3 months. Umbilical hernias are supposed to be corrected in the process of liver transplantation, provided that patients could have a better prospect to be transplanted within 3 months. Control of ascites is a crucial part to successful outcomes of umbilical hernia repair. Large volume paracentesis, concomitant peritoneovenous shunting with herniorrhaphy and transjugular intrahepatic portosystemic shunting can be applied to control refractory ascites. Emergency repair of umbilical hernias is indicated in cirrhotic patients with ascites when complications develop.
How does cluster location and intellectual capital impact entrepreneurial success within high-growth firms?
Authors: Temouri Yama , Pereira Vijay , Muschert Glenn W. , Ramiah Vikash , Babula Michael 
Published: December 2020

PurposeThe purpose of this paper is to examine the role of intellectual capital and knowledge management in the entrepreneurial success of firms through a research model which is subsequently tested empirically.Design/methodology/approachThe paper utilises the knowledge-based perspective to formulate three sets of hypotheses which the authors subsequently test in the empirical analysis on data derived from the Orbis database, which includes over 1-million data points from approximately 240,000 firms across 174 geographic subdivisions of economic regions in 14 European countries, from 2010 to 2013. The analysis utilises probit model regressions on the likelihood of becoming a high-growth firms (HGF), in the presence of a number of control factors including firm age, firm size, tangible assets, foreign ownership, competitiveness (via Herfindahl index), return on assets, industry sector and country location.FindingsFindings from our analysis suggest that investments in intangible assets and generating patents from research and development (R&D) efforts is positively related to the likelihood of becoming a HGF. In addition, cluster membership seems to be a positive influence on becoming a HGF, however the moderating impact of intangible investments and patents is less clear in clusters.Research limitations/implicationsThe authors highlight the mixed effects from cluster membership and the beneficial impact from intellectual capital and knowledge management in achieving high growth firm status.Originality/valueThe authors derive and test our research model, which outlines the interrelationship of the various factors leading to firms becoming high-growth firms. The results suggest that there may be further fruitful ground for future investigation in the intersections of knowledge management and intellectual capital concepts within entrepreneurial contexts.
Water availability rather than temperature control soil fauna community structure and prey–predator interactions
Authors: Aupic‐Samain Adriane , Baldy Virginie , Delcourt Ninon , Krogh Paul Henning , Gauquelin Thierry , Fernandez Catherine , Santonja Mathieu 
Published: December 2020

AbstractThe ongoing climate change may strongly impact soil biodiversity with cascading effects on the processes they drive. Thus, it is of prime interest to improve our knowledge about responses by soil organisms such as collembolans to expected shifts in environmental conditions by considering communities comprising both detritivores and predators.The aim of the present study was to evaluate how simulated climate change and predation under laboratory conditions alter a collembolan community.To infer the impact of climate change, we applied a decreased level of soil moisture (60% vs. 30% soil water holding capacity) and an increasing air temperature (15°C vs. 25°C) to a collembolan community constituted by four species (Folsomia candida,Protaphorura fimata,Proisotoma minutaandMesaphorura macrochaeta) exhibiting distinct functional traits, for example, body size and furca presence, in the presence or absence of a predatory gamasid AcariStratiolaelaps scimitusduring 2 months in a microcosm experiment.We observed that decreasing soil moisture altered the collembolan community with species‐specific responses. Interaction between soil moisture, temperature and predation indicates that low soil moisture reduced total collembolan abundance especially (a) by suppressing the positive effect of increasing temperature and (b) by increasing the predatory control on collembolan abundance.These results highlight that soil moisture is the major driver of Collembola community and by consequence, a shift in climatic parameters with the ongoing climate change should strongly modify the Collembola community structure and the predator–prey interaction. Our findings are highly important since a strengthening of predation impact on Collembola prey could have major consequences on the whole soil food web being able to lead to a slowdown of key ecosystem processes they drive (e.g. litter decomposition and nutrient recycling). Finally, our study promotes the need to study more complex systems considering distinct soil‐dwelling species, their functional traits and their trophic interactions to better predict the ecosystem responses to the ongoing climate change.A freePlain Language Summarycan be found within the Supporting Information of this article.
Short‐term apparent mutualism drives responses of aquatic prey to increasing productivity
Authors: Chaguaceda Fernando , Scharnweber Kristin , Dalman Erik , Tranvik Lars J. , Eklöv Peter 
Published: December 2020

Abstract

According to apparent competition theory, sharing a predator should cause indirect interactions among prey that can affect the structure and the dynamics of natural communities.

Though shifts in prey dominance and predator resource use along environmental gradients are rather common, empirical evidence on the role of indirect prey–prey interactions through shared predation particularly with increasing productivity, is still scarce.

In an 8‐week lake mesocosm experiment, we manipulated both the addition of inorganic nutrients and the presence of generalist fish predators (crucian carp, Carassius carassius L.), to test for the effects of indirect interactions through shared predation along a productivity gradient.

We found that apparent mutualism (indirect positive interaction) between benthic and pelagic prey strongly affected short‐term responses of aquatic food webs to increasing productivity in the presence of a generalist fish. Increasing productivity favoured the relative abundance of benthic prey, following trends in natural productive lake systems. This led to a shift in fish selectivity from pelagic to benthic prey driven by changes in fish behaviour, which resulted in apparent mutualism due to the lower and delayed top‐down control of pelagic prey at increasing productivity.

Our results show empirical evidence that the coupling of multiple production pathways can lead to strong indirect interactions through shared predation, whereby prey dynamics on short time‐scales are highly dependent on the foraging behaviour of generalist predators. This mechanism may play an important role in short‐term responses of food webs across environmental gradients.
A decision support tool to prioritize ballast water compliance monitoring by ranking risk of non‐indigenous species establishment
Authors: Bradie Johanna N. , Bailey Sarah A. 
Published: December 2020

Abstract

Despite the availability of research which has direct applications to environmental management, there is often a disconnect between scientific research and applied management that presents challenges for using academic knowledge in day‐to‐day operations by non‐scientists.

A science‐based decision support tool was developed in partnership with Canada's marine authority, Transport Canada, for use by ballast water inspectors in their daily operations to inform prioritization of ships for regulatory compliance inspections.

This science‐based tool combines information on the two primary pathway‐level predictors of species establishment success: environmental matching between source and recipient locations and propagule pressure (introduction effort), to generate risk estimates and relative rankings using data taken directly from ballast water reporting forms submitted by arriving ships.

This tool thus packages the best available scientific knowledge in such a way as to be readily accessible for day‐to‐day decision‐making. While this tool was developed for Canada, it could be applied in any country with very little, if any, modification. This tool can also be updated in the future to incorporate advances in scientific understanding of ballast‐mediated introductions of non‐indigenous species.

Synthesis and applications. Partnerships between scientists and managers are essential for ensuring that best‐available science translates into effective adaptive management. Recognizing a need to inform ballast water management compliance inspections, a tool was created that automatically estimates relative risk of establishment of non‐indigenous species for arriving ships. This information can be used by ballast water inspectors developing priorities for resource‐limited regulatory compliance inspections.