bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of a Latent Class Analysis in the Diagnosis of Chronic Chagas Disease in the Washington Metropolitan Area
Authors: Castro-Sesquen Yagahira E , Saldaña Antonella , Patino Nava Dhayanna , Bayangos Tabitha , Paulette Evans Diana , DeToy Kelly , Trevino Alexia , Marcus Rachel , Bern Caryn , Gilman Robert H , Talaat Kawsar R ,   Chagas Working Group in Peru and the United States, Avila Carol , Camacho Fabiola , Herrera Sdenka , Jimenez Andres , Lozano Veronika , Malaga Edith , Merida Mariel , Morales Carolina , Solis Rodrigo , Sotomayor Fiorella , Tung Alisha , Spector Anna , Verastegui Manuela , Yang Younghee , Zapata Fatima 
Published: August 2020

Abstract

Background
The diversity of individuals at risk for Trypanosoma cruzi infection in the United States poses challenges for diagnosis. We evaluated the diagnostic accuracy of Food and Drug Administration (FDA)-cleared tests in the Washington Metropolitan area (WMA).

Methods
In total, 1514 individuals were evaluated (1078 from Mexico, Central and northern South America [TcI-predominant areas], and 436 from southern South America [TcII/V/VI-predominant areas]). Optical density (OD) values from the Hemagen EIA and Chagatest v.3 Wiener, and categorical results of the IgG-TESA-blot (Western blot with trypomastigote excretory-secretory antigen), and the Chagas detect plus (CDP), as well as information of area of origin were used to determine T. cruzi serostatus using latent class analysis.

Results
We detected 2 latent class (LC) of seropositives with low (LC1) and high (LC2) antibody levels. A significantly lower number of seropositives were detected by the Wiener, IgG-TESA-blot, and CDP in LC1 (60.6%, P &lt; .001, 93.1%, P = .014, and 84.9%, P = .002, respectively) as compared to LC2 (100%, 100%, and 98.2%, respectively). LC1 was the main type of seropositives in TcI-predominant areas, representing 65.0% of all seropositives as opposed to 22.8% in TcII/V/VI-predominant areas. The highest sensitivity was observed for the Hemagen (100%, 95% confidence interval [CI]: 96.2–100.0), but this test has a low specificity (90.4%, 95% CI: 88.7–91.9). The best balance between positive (90.9%, 95% CI: 83.5–95.1), and negative (99.9%, 95% CI: 99.4–99.9) predictive values was obtained with the Wiener.

Conclusions
Deficiencies in current FDA-cleared assays were observed. Low antibody levels are the main type of seropositives in individuals from TcI-predominant areas, the most frequent immigrant group in the United States.
Clinical Outcomes Associated With Methylprednisolone in Mechanically Ventilated Patients With COVID-19
Authors: Nelson Brian C , Laracy Justin , Shoucri Sherif , Dietz Donald , Zucker Jason , Patel Nina , Sobieszczyk Magdalena E , Kubin Christine J , Gomez-Simmonds Angela 
Published: August 2020

Abstract

Background
The efficacy and safety of methylprednisolone in mechanically ventilated patients with acute respiratory distress syndrome resulting from coronavirus disease 2019 (COVID-19) are unclear. In this study, we evaluated the association between use of methylprednisolone and key clinical outcomes.

Methods
Clinical outcomes associated with the use of methylprednisolone were assessed in an unmatched, case-control study; a subset of patients also underwent propensity-score matching. Patients were admitted between 1 March and 12 April, 2020. The primary outcome was ventilator-free days by 28 days after admission. Secondary outcomes included extubation, mortality, discharge, positive cultures, and hyperglycemia.

Results
A total of 117 patients met inclusion criteria. Propensity matching yielded a cohort of 42 well-matched pairs. Groups were similar except for hydroxychloroquine and azithromycin use, which were more common in patients who did not receive methylprednisolone. Mean ventilator-free days were significantly higher in patients treated with methylprednisolone (6.21 ± 7.45 vs 3.14 ± 6.22; P = .044). The probability of extubation was also increased in patients receiving methylprednisolone (45% vs 21%; P = .021), and there were no significant differences in mortality (19% vs 36%; P = .087). In a multivariable linear regression analysis, only methylprednisolone use was associated with a higher number of ventilator-free days (P = .045). The incidence of positive cultures and hyperglycemia were similar between groups.

Conclusions
Methylprednisolone was associated with increased ventilator-free days and higher probability of extubation in a propensity-score matched cohort. Randomized, controlled studies are needed to further define methylprednisolone use in patients with COVID-19.
Effects of a Water, Sanitation, and Hygiene Mobile Health Program on Diarrhea and Child Growth in Bangladesh: A Cluster-randomized Controlled Trial of the Cholera Hospital-based Intervention for 7 Days (CHoBI7) Mobile Health Program
Authors: George Christine Marie , Monira Shirajum , Zohura Fatema , Thomas Elizabeth D , Hasan M Tasdik , Parvin Tahmina , Hasan Khaled , Rashid Mahamud-ur , Papri Nowshin , Islam Aminul , Rahman Zillur , Rafique Raisa , Islam Bhuyian Md Sazzadul , Saxton Ronald , Labrique Alain , Alland Kelsey , Barman Indrajeet , Jubyda Fatema Tuz , Afroze Farzana , Sultana Marzia , Johura Fatema-Tuz , Khan Md Abul Hasem , Tahmina Sanya , Munmun Farzana , Sack David A , Perin Jamie , Alam Munirul 
Published: August 2020

Abstract

Background
The Cholera Hospital-Based Intervention for 7 Days (CHoBI7) mobile health (mHealth) program was a cluster-randomized controlled trial of diarrhea patient households conducted in Dhaka, Bangladesh.

Methods
Patients were block-randomized to 3 arms: standard message on oral rehydration solution use; health facility delivery of CHoBI7 plus mHealth (no home visits); and health facility delivery of CHoBI7 plus 2 home visits and mHealth. The primary outcome was reported diarrhea in the past 2 weeks collected monthly for 12 months. The secondary outcomes were stunting, underweight, and wasting at a 12-month follow-up. Analysis was intention-to-treat.

Results
Between 4 December 2016 and 26 April 2018, 2626 participants in 769 households were randomly allocated to 3 arms: 849 participants to the standard message arm, 886 to mHealth with no home visits arm, and 891 to the mHealth with 2 home visits. Children &lt;5 years had significantly lower 12-month diarrhea prevalence in both the mHealth with 2 home visits arm (prevalence ratio [PR]: 0.73 [95% confidence interval {CI}, .61–.87]) and the mHealth with no home visits arm (PR: 0.82 [95% CI, .69–.97]). Children &lt;2 years were significantly less likely to be stunted in both the mHealth with 2 home visits arm (33% vs 45%; odds ratio [OR]: 0.55 [95% CI, .31–.97]) and the mHealth with no home visits arm (32% vs 45%; OR: 0.54 [95% CI, .31–.96]) compared with children in the standard message arm.

Conclusions
The CHoBI7 mHealth program lowered pediatric diarrhea and stunting among diarrhea patient households.

Clinical Trials Registration
NCT04008134.
The effect of phosphate binder therapy with sucroferric oxyhydroxide on calcification propensity in chronic haemodialysis patients: a randomized, controlled, crossover trial
Authors: Thiem Ursula , Soellradl Ina , Robl Bernhard , Watorek Ewa , Blum Sabine , Dumfarth Alexandra , Marculescu Rodrig , Pasch Andreas , Haller Maria C , Cejka Daniel 
Published: August 2020

Abstract

Background
Calcification propensity is associated with the risk for cardiovascular events and death in end-stage renal disease patients. Here we investigated the effect of lowering serum phosphate with oral phosphate binder therapy on calcification propensity.

Methods
We performed an open-label, randomized, controlled, crossover study in chronic haemodialysis patients with hyperphosphataemia. Patients (n = 39) were randomized in a 1:1 ratio to either low-dose (250 mg/day) sucroferric oxyhydroxide (SO) followed by high-dose (2000 mg/day) SO or vice versa, with washout phases before and after SO treatment. The primary endpoint was changed in calcification propensity as measured by calciprotein particle formation time (T50 test) between washout and high-dose SO treatment in patients with ≥85% adherence to the prescribed SO dose (per-protocol analysis).

Results
In the primary per-protocol analysis (n = 28), 2000 mg/day SO treatment resulted in a mean increase in T50 of 66 min (95% CI 49–84 min, P &lt; 0.0001), from 243 ± 63 to 309 ± 74 min compared with phosphate binder washout. Serum phosphate decreased from 2.28 ± 0.5 to 1.63 ± 0.43 mmol/L (P &lt; 0.0001). SO at 250 mg/day did not influence T50 (P = 0.4) or serum phosphate concentrations (P = 0.9) compared with phosphate binder washout. The secondary intention-to-treat analysis (n = 39) showed similar results: an increase in T50 of 52 min (95% CI 31–74 min, P &lt; 0.0001) and a decrease in serum phosphate from 2.18 ± 0.5 to 1.64 ± 0.46 mmol/L. No major adverse cardiovascular event, case of calciphylaxis or death occurred during the study.

Conclusion
Phosphate binder treatment with SO improves serum calcification propensity of haemodialysis patients and might lead to improved outcomes.
Long-term consequences of acute kidney injury: a narrative review
Authors: Gameiro Joana , Marques Filipe , Lopes José António 
Published: August 2020

Abstract
The incidence of acute kidney injury (AKI) has increased in the past decades. AKI complicates up to 15% of hospitalizations and can reach up to 50–60% in critically ill patients. Besides the short-term impact of AKI in patient outcomes, several studies report the association between AKI and adverse long-term outcomes, such as recurrent AKI episodes in 25–30% of cases, hospital re-admissions in up to 40% of patients, an increased risk of cardiovascular events, an increased risk of progression of chronic kidney disease (CKD) after AKI and a significantly increased long-term mortality. Despite the long-term impact of AKI, there are neither established guidelines on the follow-up care of AKI patients, nor treatment strategies to reduce the incidence of sequelae after AKI. Only a minority of patients have been referred to nephrology post-discharge care, despite the evidence of improved outcomes associated with nephrology referral by addressing cardiovascular risk and risk of progression to CKD. Indeed, AKI survivors should have specialized nephrology follow-up to assess kidney function after AKI, perform medication reconciliation, educate patients on nephrotoxic avoidance and implement strategies to prevent CKD progression. The authors provide a comprehensive review of the transition from AKI to CKD, analyse the current evidence on the long-term outcomes of AKI and describe predisposing risk factors, highlight the importance of follow-up care in these patients and describe the current therapeutic strategies which are being investigated on their impact in improving patient outcomes.
Acute kidney injury may impede results after transcatheter aortic valve implantation
Authors: Haase-Fielitz Anja , Altendeitering Fiona , Iwers Ragna , Sliziuk Veronika , Barabasch Sophie , Bannehr Marwin , Hähnel Valentin , Neuss Michael , Haase Michael , Apfelbacher Christian , Butter Christian 
Published: August 2020

Abstract

Introduction
Severe complications after transcatheter aortic valve implantation (TAVI) are rare due to increasing procedural safety. However, TAVI procedure-related haemodynamic instability and increased risk of infection may affect renal functional reserve with subsequent renal acidosis and hyperkalaemia.

Objective
In this study, we investigated incidence, modifiable risk factors and prognosis of acute kidney injury (AKI) and AKI complicated by hyperkalaemia, pulmonary oedema or metabolic acidosis after TAVI.

Methods
In a retrospective single-centre study, 804 consecutive patients hospitalized during 2017 and 2018 for elective TAVI were included. AKI was defined according to the ‘Kidney Disease Improving Global Outcome’ (KDIGO) initiative. Variables on co-morbidities, intra-/post-interventional complications and course of renal function up to 6 months after index-hospitalization were assessed. In multivariate regression analyses, risk factors for the development of AKI, complicated AKI, renal non-recovery from AKI and in-hospital mortality were determined.

Results
Incidence of AKI was 13.8% (111/804); in-hospital mortality after TAVI was 2.3%. AKI was an independent risk factor for in-hospital mortality, odds ratio (OR) 10.3 (3.4–31.6), P &lt; 0.001, further increasing to OR = 21.8 (6.6–71.5), P &lt; 0.001 in patients with AKI complicated by hyperkalaemia, pulmonary oedema or metabolic acidosis, n = 57/111 (51.4%). Potentially modifiable, interventional factors independently associated with complicated AKI were infection [OR = 3.20 (1.61–6.33), P = 0.001] and red blood cell transfusion [OR = 5.04 (2.67–9.52), P &lt; 0.001]. Valve type and size, contrast volume and other intra-interventional characteristics, such as the need for tachycardial pacing, did not influence the development of AKI. Eleven of 111 (9.9%) patients did not recover from AKI, mostly affecting patients with cardiac decompensation. In 18/111 (16.2%) patients, information concerning AKI was provided in discharge letter. Within 6 months after TAVI, higher proportion of patients with AKI showed progression of pre-existing chronic kidney disease compared with patients without AKI [14/29, 48.3% versus 54/187, 28.9%, OR = 2.3 (95% confidence interval 1.0–5.1), P = 0.036].

Conclusions
AKI is common and may impede patient outcome after TAVI with acute complications such as hyperkalaemia or metabolic acidosis and adverse renal function until 6 months after intervention. Our study findings may contribute to refinement of allocation of appropriate level of care in and out of hospital after TAVI.
Lost In Translation: Exposing Hidden Compiler Optimization Opportunities
Authors: Georgiou Kyriakos , Chamski Zbigniew , Amaya Garcia Andres , May David , Eder Kerstin 
Published: August 2020

Abstract
Existing iterative compilation and machine learning-based optimization techniques have been proven very successful in achieving better optimizations than the standard optimization levels of a compiler. However, they were not engineered to support the tuning of a compiler’s optimizer as part of the compiler’s daily development cycle. In this paper, we first establish the required properties that a technique must exhibit to enable such tuning. We then introduce an enhancement to the classic nightly routine testing of compilers, which exhibits all the required properties and thus is capable of driving the improvement and tuning of the compiler’s common optimizer. This is achieved by leveraging resource usage and compilation information collected while systematically exploiting prefixes of the transformations applied at standard optimization levels. Experimental evaluation using the LLVM v6.0.1 compiler demonstrated that the new approach was able to reveal hidden cross-architecture and architecture-dependent potential optimizations on two popular processors: the Intel i5-6300U and the Arm Cortex-A53-based Broadcom BCM2837 used in the Raspberry Pi 3B+. As a case study, we demonstrate how the insights from our approach enabled us to identify and remove a significant shortcoming of the CFG simplification pass of the LLVM v6.0.1 compiler.
Advancing scientific knowledge and conservation of birds through inclusion of conservation social sciences in the American Ornithological Society
Authors: Dayer Ashley A , Barnes Jessica C , Dietsch Alia M , Keating Jacqueline M , Naves Liliana C 
Published: August 2020

Abstract
Conservation efforts are shaped by individual and collective human behaviors, cultural norms and values, economic pressures, and political and organizational structures. As such, the conservation social sciences—disciplines that draw on social science theories and approaches to improve conservation efforts—can play a vital role in advancing the science and practice of bird conservation. We connect the rich, ongoing discussion about the vital role of the conservation social sciences to the specific context of bird conservation and make an argument for the importance of proactive inclusion of these sciences in ornithological societies. First, we introduce the conservation social sciences and illustrate how they can improve the design and implementation of conservation programs and policies for birds. Drawing on discussions from a symposium we organized at the 2019 American Ornithological Society (AOS) annual meeting, we encourage the AOS to make institutional changes that could further support the inclusion of conservation social sciences. These changes ideally would include a working group, conference plenaries and themes, and high-quality social science publications, along with support and encouragement for ornithologists and bird conservationists to partake in trainings and collaborate with social scientists. Strategies for how to do so effectively can be adapted from other conservation societies that have paved the way for disciplinary inclusivity.
Validation of a novel method to create temporal records of hormone concentrations from the claws of ringed and bearded seals
Authors: Karpovich Shawna A , Horstmann Larissa A , Polasek Lori K 
Published: August 2020

AbstractRinged (Pusa hispida) and bearded seals (Erignathus barbatus) inhabit vast and often remote areas in the Arctic, making it difficult to obtain long-term physiological information concerning health and reproduction. These seals are experiencing climate-driven changes in their habitat that could result in physiological stress. Chronic physiological stress can lead to immunosuppression, decreased reproduction and decreased growth. Recently, keratin has become a popular matrix to measure steroid hormones, such as stress-related cortisol and reproduction-related progesterone. We developed and validated methods to extract cortisol and progesterone from the claws of adult female ringed (n = 20) and bearded (n = 3) seals using enzyme immunosorbent assays. As ringed and bearded seal claws grow, a pair of dark- and light-colored bands of keratin is deposited annually providing a guide for sampling. Two processing methods were evaluated, removal of claw material with a grinding bit or grinding followed by mechanical pulverization (102 paired samples from six claws, two each from three seals). Adding the mechanical pulverization step resulted in a 1.5-fold increase in hormone extraction. Progesterone from the proximal claw band was evaluated to biologically validate claw material as a measure of pregnancy in ringed seals (n = 14). Claws from pregnant seals had significantly higher claw progesterone concentrations than from non-pregnant seals. This suggests that the elevated progesterone associated with gestation was reflected in the claws, and that the most proximal claw band was indicative of pregnancy status at time of death. Thus, although the sample size was low and the collection dates unbalanced, this study demonstrates the potential to use claws to examine an extended time series (up to 12 yrs) of cortisol and progesterone concentrations in ringed and bearded seal claws.
Thoreau’s luminous Homer in A Week on the Concord and Merrimack Rivers
Authors: Parker Luke 
Published: August 2020

AbstractHenry David Thoreau’s relationship to Greek literature, and Homer’s Iliad in particular, is more often remarked than analysed. This article argues that Thoreau’s engagement with Homer in his first book, A Week on the Concord and Merrimack Rivers, proves central to the themes of that work highlighted by critics as well as its less-studied formal hybrid of poetry and prose. I show that Thoreau constructs Homer as the poetic ideal in which the perennially renewed life of the natural world becomes accessible to human beings caught in the fatal and unidirectional movement of historical time. Thoreau’s ideas here may track Romantic conceptions of Homer and Greek literature more generally, but Thoreau turns contemporary uncertainty around the person of Homer into reflection on the relationship between personal experience and literary expression of ‘living nature’. This turns out to structure a larger dichotomy between poetry and prose, one in which Thoreau associates the latter with authentic experience and self-expression of an individual human life. In A Week’s engagement with Homer, then, we see Thoreau negotiating not only some core concerns of his writing but also his evolution from aspiring poet to author of the works in prose that ultimately define his career.
Neuroscience-Based Mindfulness Social Work Practice in Schools
Authors: Blundo Robert , Savage Tamara Estes 
Published: August 2020

AbstractChronic poverty and stressful life circumstances result in poor school performance and behaviors. Research demonstrates that these behaviors are not the result of student inadequacies and lack of proper discipline, but are rather of neurological adaptations to chronic poverty and toxic stress. These outcomes are driven by the body’s attempt to protect itself even as the behaviors appear to be choices the student is making in a rational world. Neurobiologically, students adapt to these challenges by becoming both hypersensitive and self-protective. As a result, students are mistrustful and on alert beyond what is usual as a way of protecting themselves, consciously or unconsciously. Mindfulness programs provide important tools for shifting these challenges in the classroom by supporting feelings of safety and opportunities for growth and change in student learning and behaviors. Demonstrating the actual practice of mindfulness is not our intent given that there are many ways of using and learning mindfulness in the classroom. Rather, the focus is on the neurological outcomes of stressful lives, the neurological impact of mindfulness training, and providing resources for addressing student negative experiences and behaviors in schools.