bluuebunny/crossref_metadata_2025_split huggingface dataset:
B2B social media content: engagement on LinkedIn
Authors: Sundström Malin , Alm Klas Håkan , Larsson Niklas , Dahlin Oskar 
Published: September 2020

PurposeThis paper aims to identify content strategies on social media that influence engagement and to analyze those operations to describe important features for co-creation and trust.Design/methodology/approachThis paper addresses the question of how social media content can influence engagement by using a medium-sized Swedish company for an empirical case study. This empirical study is based on a participatory action research methodology. By using the company account on LinkedIn, the authors experimented with relational content to understand the effects on customer-perceived value and trust.FindingsResults reveal that action-oriented messages had a more significant impact on engagement than product-oriented messages and value-based messages.Originality/valueThis paper builds on the existing literature in two ways: drawing upon business-to-business relationships and perceived value and using recent advances in the use of social networking sites to understand the value of co-creation through a participatory culture.
The effect of family business exposure on individuals' entrepreneurial intentions: an institutional theory perspective
Authors: Zaman Sarfraz , Arshad Muhammad , Sultana Naheed , Saleem Sharjeel 
Published: September 2020

PurposeThe purpose of this study is to examine the effect of family business exposure on individuals' entrepreneurial intentions (EIs). By applying the institutional framework at the micro level, this study proposed the mediation of three types of institutional forces (coercive, normative and mimetic) between the relationship of family business exposure and EIs.Design/methodology/approachData were collected from 367 university students in Pakistan. The survey design was used for the data collection. The measurement and hypothesized models were tested using the structural equation modeling technique in Mplus 7.0.FindingsThe findings of this study revealed that family business exposure positively influenced the institutional forces (coercive, normative and mimetic) which further developed the individuals' EIs. However, family business exposure did not affect the EIs directly that showed the full mediation of institutional forces between the relationship of family business exposure and EIs.Originality/valueThis is the first study in its nature which applied institutional theory from the macro level to the micro level within the context of family business. The results revealed the institutional forces as the underpinning mechanism which explains the relationship between family business exposure and EIs.
Dark side of the family business: an exploratory perspective
Authors: Montiel Mendez Oscar Javier , Soto Maciel Argentina 
Published: September 2020

PurposeThe paper aims to relate the potential elements identified as the dark side of the family business (DSFB), where these elements can be productive or destructive. The “dark side” comprises an important contribution for entrepreneurship and family business (FB) studies, a novel perspective.Design/methodology/approachThe relevant literature on entrepreneurship and FB was selected and analyzed according to the “dark side” framework.FindingsThe results suggest that many perspectives remain for research, starting with a clarification and a more precise definition, not only of the construct itself but also of the factors or forces that drive this dark side, from the entrepreneur/founder, the FB itself and the context. This approach considers a systemic position in which the context plays a significant and decisive role.Practical implicationsThe paper has implications for the development of public policies. Business incubation entities, federal, state and local entrepreneurship/small- and medium-sized enterprise (SME) programs, educational institutions and entrepreneurial families and their founders can become more aware and establish courses of action.Originality/valueThis paper makes a call to propose an initial point for conceptualizing the logic behind the DSFB for obtaining a deeper understanding with regard to future research. Researchers are encouraged to test the conceptual model further.
Effects of collaborative consultation using iPad application in school‐based occupational therapy: A single‐arm pre‐post pilot study
Authors: Yamaguchi Sayaka , Okutsu Mitsuyoshi , Tomori Kounosuke , Nagayama Hirofumi , Okita Yuho 
Published: September 2020

AbstractIntroductionThis pilot study examined the effect of collaborative consultation with teachers in school‐based occupational therapy (SBOT) using iPad application for goal‐setting—Aid for Decision‐Making in Occupation Choice for School (ADOC‐S).MethodA single arm pre‐post intervention design was conducted at four preschools in Japan. The participants were 10 preschool teachers (10.5 ± 0.4 years of teaching), and 10 children (3.8 ± 0.4 years old; five boys). The teachers received three collaborative consultations (1 hr for each) from one occupational therapist. Firstly, the occupational therapist conducted an observational assessment of the child's school life, then the teacher and occupational therapist identified occupation‐based goals for each child using the ADOC‐S. Secondly, the teacher and the occupational therapist developed the graded goals using the Goal Attainment Scale (GAS) and discussed the daily intervention plan for the teachers to conduct. Thirdly, the occupational therapist followed up on the intervention process using GAS. The subjective outcome was measured at 10 point‐satisfaction and performance score in each goal using Canadian Occupational Performance Measure (COPM). The observed outcome was measured using GAS and Strengths and Difficulties Questionnaire (SDQ).ResultsAll the participants including teachers and children successfully underwent the intervention process. Significant improvement was found pre‐post and effect size (ES) was large on the COPM (ES; r = .85–.94), GAS (ES; r = .98–.99) and SDQ (ES; r = .64). All goals (30/30) exceeded expectations of GAS from zero to +2.ConclusionAlthough there are some limitations and considerations which need to be resolved for future studies, our results suggest that ADOC‐S would help build a rapport with a teacher in SBOT settings, and this collaborative consultation would facilitate a positive outcome.
The biogeochemical variability of Arctic thermokarst ponds is reflected by stochastic and niche‐driven microbial community assembly processes
Authors: Le Moigne Alizée , Bartosiewicz Maciej , Schaepman‐Strub Gabriela , Abiven Samuel , Pernthaler Jakob 
Published: September 2020

SummaryShallow thermokarst ponds are a conspicuous landscape element of the Arctic Siberian tundra with high biogeochemical variability. Little is known about how microbes from the regional species pool assemble into local pond communities and how the resulting patterns affect functional properties such as dissolved organic carbon (DOC) remineralization and greenhouse gas (GHG) turnover. We analysed the pelagic microbiomes of 20 ponds in north‐eastern Siberia in the context of their physico‐chemical properties. Ponds were categorized as polygonal or trough according to their geomorphological origin. The diversity of bacteria and eukaryotic microbes was assessed by ribosomal gene tag sequencing. Null model analysis revealed an important role of stochastic assembly processes within ponds of identical origin, in particular for genotypes only occurring in few systems. Nevertheless, the two pond types clearly represented distinct niches for both the bacterial and eukaryotic microbial communities. Carbon dioxide concentration, indicative of heterotrophic microbial processes, varied greatly, especially in the trough ponds. Methane concentrations were lower in polygonal ponds and were correlated with the estimated abundance of methanotrophs. Thus, the overall functional variability of Arctic ponds reflects the stochastic assembly of their microbial communities. Distinct functional subcommunities can, nevertheless, be related to GHG concentrations.
The unconventional adverse effects of fungal pretreatment on iturin A fermentation by Bacillus amyloliquefaciens CX‐20
Authors: Chen Wenchao , Wang Meng , Gong Yangmin , Deng Qianchun , Zheng Mingming , Chen Shouwen , Wan Xia , Yang Chen , Huang Fenghong 
Published: September 2020

SummaryFungal pretreatment is the most common strategy for improving the conversion of rapeseed meal (RSM) into value‐added microbial products. It was demonstrated that Bacillus amyloliquefaciens CX‐20 could directly use RSM as the sole source of all nutrients except the carbon source for iturin A fermentation with high productivity. However, whether fungal pretreatment has an impact on iturin A production is still unknown. In this study, the effects of fungal pretreatment and direct bio‐utilization of RSM for iturin A fermentation were comparatively analysed through screening suitable fungal species, and evaluating the relationships between iturin A production and the composition of solid fermented RSM and liquid hydrolysates. Three main unconventional adverse effects were identified. (1) Solid‐state fermentation by fungi resulted in a decrease of the total nitrogen for B. amyloliquefaciens CX‐20 growth and metabolism, which caused nitrogen waste from RSM. (2) The released free ammonium nitrogen in liquid hydrolysates by fungal pretreatment led to the reduction of iturin A. (3) The insoluble precipitates of hydrolysates, which were mostly ignored and wasted in previous studies, were found to have beneficial effects on producing iturin A. In conclusion, our study verifies the unconventional adverse effects of fungal pretreatment on iturin A production by B. amyloliquefaciens CX‐20 compared with direct bio‐utilization of RSM.
Relationship of Wnt pathway activity and organ involvement in scleroderma types
Authors: Koçak Ayşe , Harmancı Duygu , Güner Akdoğan Gül , Birlik Merih 
Published: September 2020

AbstractObjectiveScleroderma (SSc) is a chronic inflammatory autoimmune disease characterized by fibrosis in the skin and internal organs. In SSc, the heart, lung, kidney, gastrointestinal (GIS) system, muscle, and peri‐articular structures are damaged. There is no study of the relationship between SSc type, stage, pathogenesis, organ involvement, and Wnt signaling. In this study, we aimed to show the relationship of the Wnt gene family and antagonists in SSc subtypes and different organ involvement.MethodsEighty‐five SSc patients and 77 controls were included in this study. The gene expressions and protein levels of the Wnt family and antagonists were analyzed from blood samples. The relationship between these parameters and disease stage, type, and organ involvement were evaluated.ResultsWnt‐1, Wnt‐10b, Wnt‐2, and Wnt‐6 gene expressions are increased and Axin‐2, DKK‐1, and Kremen protein expressions are decreased in SSc. Wnt‐3a and Wnt‐10a gene expressions are increased in generalized SSc compared to limited SSc. Wnt‐1, Wnt‐2 gene expressions are increased significantly in pulmonary arterial hypertension (PAH)(+) SSc compared to PAH(−) SSc. There was a positive correlation between the modified Rodnan skin score and Wnt‐2 in SSc. There was a significant positive correlation between GIS involvement score and Wnt‐1, Wnt‐2, Wnt‐4, Wnt‐8a, Wnt‐9b in SSc.ConclusionWnt‐1 and Wnt‐2 were found higher in scleroderma and organ involvement. They may play a role in the pathogenesis of the disease.
Evaluation of inflammatory rheumatic diseases from an emergency medicine perspective
Authors: San Ishak , Erden Abdulsamet , Gemcioglu Emin , Kücüksahin Orhan 
Published: September 2020

AbstractBackgroundPatients with rheumatological complaints may visit an emergency department (ED) because of an acute attack or complication. Because of the recent increased use of immunosuppressant drugs to treat rheumatic diseases, more patients with these conditions visit the ED with a complaint about an infection. However, there are little data on the ED visits of patients with rheumatological complaints. This study evaluated the ED visits of patients with inflammatory rheumatic diseases.Materials and MethodsA total of 2715 patients (1753 females, 962 males) who had been diagnosed with an inflammatory rheumatic disease and followed up at the rheumatology clinic of Yıldırım Beyazit University, Ankara Atatürk Training and Research Hospital between April 2014 and April 2018 were included in the study. The demographic, clinical, and laboratory characteristics of the patients were obtained from the hospital patient records. The ED visits of these patients were classified into five triage groups (T1: critical, T2: very urgent, T3: urgent, T4: less urgent, T5: not urgent).ResultsOf the 2715 patients, 577 (21.3%) had visited the ED. The three most numerous groups who visited the ED were patients with rheumatoid arthritis (19.8%), ankylosing spondylitis (19.2%), and familial Mediterranean fever (15.9%). Of these 577 patients, 347 (60.1%) were discharged from the ED, 209 (36.2%) were hospitalized in the wards, and 21 (3.6%) were hospitalized in the intensive care unit (ICU). The 3 main reasons for visiting the ED were fever and malaise (n = 152, 26.3%), musculoskeletal complaints (n = 125, 21.7%), and abdominal pain (n = 89, 15.4%). The most numerous group of patients referred by the ED to the wards had vasculitis (n = 38, 17.9%), while the most numerous group of patients referred to the ICU had scleroderma (n = 7, 33.3%). Of the 21 patients who were referred by the ED to the ICU, 16 (76.1%) had respiratory system complaints. Of the 577 patients, 10 (1.7%) died. Eight of the 10 patients (80%) had a rheumatic disease and died after admission to the ICU. The other 2 patients had been diagnosed with pneumonia and myocardial infarction, respectively.ConclusionsOur study found that visits to the ED by patients with inflammatory rheumatic diseases were classified as urgent or less urgent. Patients with rheumatoid arthritis were the most numerous ED visitors. Vasculitis was the most common cause of hospitalization in the wards and scleroderma was the most common cause of hospitalization in the ICU and death. This suggests that ED physicians should be aware of these patients.
Rock art survey in the ancient oasis of Salūt (northern Sultanate of Oman): a variegated iconographic record
Authors: Degli Esposti Michele , Cremaschi Mauro , Zerboni Andrea 
Published: September 2020

AbstractThe systematic survey of petroglyphs in the area of the ancient oasis of Salūt, in central Oman, highlighted a rich repertoire of representations that are here discussed against the background of Arabian rock art in general. The region displays an extremely rich number of engravings along the slopes of the Jabal Hammah, north of the main site of Salūt. The majority of the petroglyphs find abundant fitting comparisons in the region. The notable exception of the motif of the “man with halberd” is presented, as it appears to be significantly rare and underlines interpretative issues concerning the so‐called T‐shaped signs, ubiquitous in Arabian rock art. One of its occurrences was radiocarbon dated to before the mid‐first millennium BCE. This and other, relative hints for reconstructing the chronological context of the petroglyphs are discussed, indicating that engravings can be broadly dated from the second millennium BCE onwards.
Development of a comprehensive Percutaneous Dilatational Tracheostomy process model for procedural training: A Delphi‐based experts consensus
Authors: de la Fuente Rene , Kattan Eduardo , Munoz‐Gama Jorge , Puente Ignacio , Navarrete Matías , Kychenthal Catalina , Fuentes Ricardo , Bravo Sebastian , Galvez Victor , Sepúlveda Marcos 
Published: September 2020

AbstractBackgroundDeconstructing a complex procedure improves skills learning, but no model has covered all relevant Percutaneous Dilatational Tracheostomy (PDT) procedural aspects. Moreover, the heterogeneity of techniques described may hinder trainees’ competency acquisition. Our objective was to develop a PDT model for procedural training that includes a comprehensive step‐by‐step design.MethodsProcedural descriptions were retrieved after a structured search in medical databases. Activities were extracted and the adherence to McKinley's dimensions of procedural competence was analyzed. We developed a comprehensive PDT model, which was further validated through a Delphi‐based consensus of Spanish‐speaking international experts.ResultsThe 14 descriptions retrieved for analysis presented a median [interquartile range] of 18 [11‐22] steps, covering 3 [2‐4] of McKinley's dimensions. The Delphi panel's first model included all McKinley's dimensions, and was answered by 25 experts from nine countries, ending in the second round. The final model included 59 activities divided into six stages (51 from the initial model and eight proposed by experts) and performed by two operators (bronchoscopy and tracheostomy).ConclusionsWe have presented a PDT model that includes necessary competence dimensions to be considered complete. The model was validated by an experts’ consensus, allowing to improve procedural training to promote safer patient care.
Clearance of senescent cells during cardiac ischemia–reperfusion injury improves recovery
Authors: Dookun Emily , Walaszczyk Anna , Redgrave Rachael , Palmowski Pawel , Tual‐Chalot Simon , Suwana Averina , Chapman James , Jirkovsky Eduard , Donastorg Sosa Leticia , Gill Eleanor , Yausep Oliver E , Santin Yohan , Mialet‐Perez Jeanne , Andrew Owens W , Grieve David , Spyridopoulos Ioakim , Taggart Michael , Arthur Helen M. , Passos João F. , Richardson Gavin D. 
Published: September 2020

AbstractA key component of cardiac ischemia–reperfusion injury (IRI) is the increased generation of reactive oxygen species, leading to enhanced inflammation and tissue dysfunction in patients following intervention for myocardial infarction. In this study, we hypothesized that oxidative stress, due to ischemia–reperfusion, induces senescence which contributes to the pathophysiology of cardiac IRI. We demonstrate that IRI induces cellular senescence in both cardiomyocytes and interstitial cell populations and treatment with the senolytic drug navitoclax after ischemia–reperfusion improves left ventricular function, increases myocardial vascularization, and decreases scar size. SWATH‐MS‐based proteomics revealed that biological processes associated with fibrosis and inflammation that were increased following ischemia–reperfusion were attenuated upon senescent cell clearance. Furthermore, navitoclax treatment reduced the expression of pro‐inflammatory, profibrotic, and anti‐angiogenic cytokines, including interferon gamma‐induced protein‐10, TGF‐β3, interleukin‐11, interleukin‐16, and fractalkine. Our study provides proof‐of‐concept evidence that cellular senescence contributes to impaired heart function and adverse remodeling following cardiac ischemia–reperfusion. We also establish that post‐IRI the SASP plays a considerable role in the inflammatory response. Subsequently, senolytic treatment, at a clinically feasible time‐point, attenuates multiple components of this response and improves clinically important parameters. Thus, cellular senescence represents a potential novel therapeutic avenue to improve patient outcomes following cardiac ischemia–reperfusion.
Morphological features of lower respiratory tract of nine‐banded armadillo (Dasypus novemcinctus, Linnaeus, 1758)
Authors: Araújo João Victor Silva , de Barros Gabriel Martins , Cavalcante Maria Michele Araújo de Sousa , Silva Andrezza Braga Soares da , Monção Élida da Costa , Mendonça Tarsia Giabardo Silva , Mendes Júnior Aírton Conde 
Published: September 2020

AbstractThe nine‐banded armadillo (Dasypus novemcinctus) is a mammal of the Xenarthra Superorder, which inhabits Central, South and North America. Few morphological descriptions are observed in this species, including the respiratory tract; therefore, the objective of this study was to describe morphologically the lower respiratory tract of the nine‐banded armadillo. Five animals were dissected, and the macroscopic and microscopic aspects were analysed. In the anatomical analysis, the perfusion technique was performed with vinyl acetate and the fragments of tissue from respiratory organs (trachea, bronchi, bronchioles and pulmonary lobes) were stained with haematoxylin–eosin for visualization under optical microscopy. Containing about 30 cartilage rings, the trachea is lined internally with ciliated pseudostratified epithelial tissue. The lungs are subdivided into lobes by deep interlobar fissures, with two lobes in the right lung and three lobes in the left lung. Microscopically, the primary, secondary and tertiary bronchi have non‐ciliated pseudostratified epithelium with goblet cells. It was found that macro‐ and microscopically the respiratory tract of this species is similar to existing xenarthras and other excavator animals. These data provide subsidies for the clinic and preservation of this species.
Epicutaneous immunotherapy protects cashew‐sensitized mice from anaphylaxis
Authors: Pelletier Benjamin , Perrin Audrey , Assoun Noémie , Plaquet Camille , Oreal Nathalie , Gaulme Laetitia , Bouzereau Adeline , Labernardière Jean‐Louis , Ligouis Mélanie , Dioszeghy Vincent , Wavrin Sophie , Matthews Katie , Porcheray Fabrice , Sampson Hugh A. , Hervé Pierre‐Louis 
Published: September 2020

AbstractBackgroundThe prevalence of tree nut allergy has increased worldwide, and cashew has become one of the most common food allergens. More critically, cashew allergy is frequently associated with severe anaphylaxis. Despite the high medical need, no approved treatment is available and strict avoidance and preparedness for prompt treatment of allergic reactions are considered dual standard of care. In the meantime, Phase III study results suggest investigational epicutaneous immunotherapy (EPIT) may be a relevant and safe treatment for peanut allergy and may improve the quality of life for many peanut allergic children.ObjectiveWe aimed to evaluate the capacity of EPIT to provide protection against cashew‐induced anaphylaxis in a relevant mouse model.MethodsThe efficacy of EPIT was evaluated by applying patches containing cashew allergens to cashew‐sensitized mice. As negative control, sham mice received patches containing excipient. Following treatment, mice were challenged orally to cashew and anaphylactic symptoms, as well as plasmatic levels of mast‐cell proteases (mMCP)‐1/7, were quantified.ResultsOf 16 weeks of EPIT significantly protects against anaphylaxis by promoting a faster recovery of challenged mice. This protection was characterized by a significant reduction of temperature drop and clinical symptoms, 60 minutes after challenge. This was associated with a decrease in mast‐cell reactivity as attested by the reduction of mMCP‐1/7 in plasma, suggesting that EPIT specifically decrease IgE‐mediated anaphylaxis.ConclusionWe demonstrate that EPIT markedly reduced IgE‐mediated allergic reactions in a mouse model of cashew allergy, which suggests that EPIT may be a relevant approach to treating cashew allergy.