bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of dielectric gradients‐mediated ions partitioning on the electrophoresis of composite soft particles: An analytical theory
Authors: Mahapatra Paramita , Gopmandal Partha P. , Duval Jérôme F. L. 
Published: July 2020

AbstractIn this work, we report original analytical expressions defining the electrophoretic mobility of composite soft particles comprising an inner core and a surrounding polymer shell with differentiated permeabilities to ions from aqueous background electrolyte and to fluid flow developed under applied DC field conditions. The existence of dielectric permittivity gradients operational at the core/shell and shell/solution interfaces is accounted for within the Debye–Hückel approximation and flat plate configuration valid in the thin double layer regime. The proposed electrophoretic mobility expressions, applicable to weakly to moderately charged particles with size well exceeding the Debye layer thickness, involve the relevant parameters describing the particle core/shell structure and the electrohydrodynamic features of the core and shell particle components. It is shown that the analytical expressions reported so far in literature for the mobility of hard (impermeable) or porous particles correspond to asymptotic limits of the more generic results detailed here. The impacts of dielectric‐mediated effects of ions partitioning between bulk solution and particle body on the electrophoretic response are further discussed. The obtained expressions pave the way for a refined quantitative, analytical interpretation of electrophoretic mobility data collected on soft (nano)particles (e.g., functionalized dendrimers and multilayered polyelectrolytic particles) or biological cells (e.g., viruses) for which the classical hard core‐soft shell representation is not appropriate.
Performance analysis of PV array configurations (SP, BL, HC and TT) to enhance maximum power under non‐uniform shading conditions
Authors: Bonthagorla Praveen Kumar , Mikkili Suresh 
Published: July 2020

AbstractPartial shading condition (PSC) causes the significant increase in power losses of solar photovoltaic arrays. Partial shading is due to the shadows of passing clouds, chimneys, trees, bird droppings, various tall building structures etc. At the PSCs, the local hotspots are formed in the partially shaded PV modules due to increase in temperature of the shaded module during its operation in reverse bias condition. The hotspots in the PV modules can be avoided by connecting bypass diodes in anti‐parallel to the modules. But due to the functioning of bypass diodes, several peaks are produced in the I‐V and P‐V characteristics. Apart from this phenomenon, the mismatch losses are also arises between the modules with significant reduction in output power from the PV array. The objective of this paper is to model, analyze, simulate and evaluate the performance of 7 × 7 PV array configurations such as Series‐Parallel, Bridge‐Link, Honey‐Comb and Triple‐Tied in the presence of various PSCs. The PSCs considered are corner, center, right side end, bottom side end, L‐shape, frame, random and diagonal shadings. The performance of these configurations under different shading patterns have been compared and analyzed with the performance parameters like open circuit voltage, short circuit current, global peak power (GPP), voltages and currents at GPP, number of local peak powers (LPPs), voltages and currents at LPP, mismatch losses, fill factor and efficiency. All the configurations are simulated by using KYOCERA‐KC200GT PV module specifications.
Global Survey of Guidelines for the Management of Epilepsy in Pregnancy: A report from the International League Against Epilepsy Task Force on Women and Pregnancy
Authors: Tomson Torbjörn , Battino Dina , Bromley Rebecca , Kochen Silvia , Meador Kimford J. , Pennell Page B. , Thomas Sanjeev V. 
Published: July 2020

AbstractThe ILAE Task Force on Women and Pregnancy conducted a survey among ILAE Chapters of their use of guidelines or recommendations for the management of women with epilepsy during pregnancy. A web‐based questionnaire including 10 questions was sent to the 118 ILAE Chapters in December 2017 with repeated reminders until the end of February 2018. In total, 77 chapters (65%) responded, although not to all questions. Out of those responding, 68% reported having guidelines or recommendations, 34% of which were from 2014 or earlier. At least 20% of the guidelines did not include information on possible risk to cognitive development, information regarding specific risks with specific antiepileptic drugs, nor recommendations regarding selection of antiepileptic drugs. Among those responding to the question, 91% reported that recommendations were made regarding folate supplementation, but the recommended dose ranged from 0.4 mg/d to 4 mg/d or more; 34% did not include recommendations regarding drug level monitoring during pregnancy, and 19% did not include guidelines on breastfeeding. Our survey demonstrates that there is a need for the development of up‐to‐date, globally applicable recommendations for the management of epilepsy during pregnancy.
Model‐data fusion for seismic performance evaluation of an instrumented highway bridge
Authors: Parida Siddharth S. , Nikellis Alexandros , Sett Kallol , Singla Puneet 
Published: July 2020

SummaryThe paper presents a computationally efficient algorithm to integrate a probabilistic, non‐Gaussian parameter estimation approach for nonlinear finite element models with the performance‐based earthquake engineering (PBEE) framework for accurate performance evaluations of instrumented civil infrastructures. The algorithm first utilizes a minimum variance framework to fuse predictions from a numerical model of a civil infrastructure with its measured behavior during a past earthquake to update the parameters of the numerical model that is, then, used for performance prediction of the civil infrastructure during future earthquakes. A nonproduct quadrature rule, based on the conjugate unscented transformation, forms an enabling tool to drive the computationally efficient model prediction, model‐data fusion, and performance evaluation. The algorithm is illustrated and validated on Meloland Road overpass, a heavily instrumented highway bridge in El Centro, CA, which experienced three moderate earthquake events in the past. The benefits of integrating measurement data into the PBEE framework are highlighted by comparing damage fragilities of and annual probabilities of damages to the bridge estimated using the presented algorithm with that estimated using the conventional PBEE approach.
Repetitive transcranial magnetic stimulation treatment in severe, enduring anorexia nervosa: An open longer‐term follow‐up
Authors: Dalton Bethan , Lewis Yael D. , Bartholdy Savani , Kekic Maria , McClelland Jessica , Campbell Iain C. , Schmidt Ulrike 
Published: July 2020

AbstractObjectiveThis study assessed longer‐term outcomes from a randomised controlled feasibility trial of 20 sessions of real versus sham high‐frequency repetitive transcranial magnetic stimulation (rTMS) to the left dorsolateral prefrontal cortex in adults with severe, enduring anorexia nervosa (SE‐AN).MethodsThirty participants who completed the original study protocol were invited to take part in an open follow‐up (18‐months post‐randomisation), assessing body mass index (BMI), eating disorder (ED) symptoms and other psychopathology.ResultsTwenty‐four participants (12 each originally allocated to real/sham) completed the 18‐month follow‐up. Ten of 12 participants who originally received sham treatment had real rTMS at some stage during the follow‐up. A medium between‐group effect size was seen for BMI change from baseline to 18‐months, favouring those originally allocated to real rTMS. In this group at 18‐months, five participants were weight recovered (BMI ≥18.5 kg/m2), compared with one participant in the original sham group. Both groups showed further improvement in ED symptoms during the follow‐up. Effects on mood were largely maintained at follow‐up, with catch‐up effects in the original sham group.ConclusionsFindings suggest that rTMS treatment effects on mood are durable and that BMI and ED symptom improvements need time to emerge. Large‐scale trials are needed.
Optimal probabilistic scenario‐based operation and scheduling of prosumer microgrids considering uncertainties of renewable energy sources
Authors: Faraji Jamal , Hashemi‐Dezaki Hamed , Ketabi Abbas 
Published: July 2020

AbstractUncertainties of renewable energy sources (RESs) such as wind turbine (WT) and photovoltaic (PV) units are one of the considerable challenges of prosumer microgrids (PMGs) for the optimal day‐ahead operation. In this study, a new probabilistic scenario‐based method of optimal scheduling and operation of PMGs is developed. In this regard, different scenarios are generated using Monte Carlo Simulations (MCS). Furthermore, k‐means, k‐medoids, and differential evolution algorithms (DEA) are deployed to cluster the scenarios in the proposed method. A realistic commercial PMG in Iran is selected to apply the introduced method. The validity of the developed probabilistic optimization method for PMG operation is examined by comparing the results under various scenario reduction algorithms and MCS ones. The comparison of the obtained results and those of other existing deterministic methods highlights the advantages of the presented method. Furthermore, the sensitivity analyses are carried out to investigate the robustness of the developed method against the increase in the system uncertainty level. According to the test results, it is concluded that the k‐medoids algorithm has the best performance in comparison with the k‐means and the DEA‐based clustering under various conditions.
Feasibility, acceptability and future adaptation of the Chinese translated Behavioural activation (C‐BA) treatment for depression: A pilot study
Authors: Chen Yun , Anand Deepika , Li Haolin , Xu Peng , Daughters Stacey B. 
Published: July 2020

Background: Although depression is prevalent among Chinese international students (CIS), only 4% of CIS seek treatment. Behavioural activation (BA) has been suggested as a culturally sensitive treatment for depression that has the potential to meet the clinical needs of CIS. The current pilot study tested the feasibility, acceptability and themes for future cultural adaptations of a Chinese translated BA treatment (C‐BA) among CIS.Methods: Six CIS with elevated depressive symptoms (Beck Depression Inventory, BDI ≥ 14) completed a six‐session individual C‐BA treatment and assessments at pre‐ and post‐treatment and a 1‐month follow‐up. Primary outcome measures included treatment feasibility, acceptability and qualitative interview data informing future adaption of C‐BA. Exploratory analyses examined group changes in depressive symptoms over time and clinically significant symptom changes on individual levels.Results: All participants found the treatment to be highly feasible and culturally acceptable, and were highly engaged in the treatment. Themes of future cultural adaptions were generated from the qualitative interviews. Significant decreases in depressive symptoms were observed at a one1‐month post‐treatment follow‐up assessment.Conclusions: Preliminary evidence suggests that C‐BA has the potential to be a culturally sensitive treatment for depression among CIS. CIS demonstrated openness to psychotherapy and high treatment engagement.
Antiproliferative effect and autophagy induction of curcumin derivative ZYX02‐Na on the human lung cancer cells A549
Authors: Zhou Guang‐Zhou , Guo Shuang‐Shuang , Liu Deng‐Xu , Zhang Lu , Sun Gang‐Chun 
Published: July 2020

AbstractAt present, a large number of curcumin derivatives had been produced and identified aiming to replace the curcumin in view of its low bioavailability and stability. Here, a novel curcumin derivative ZYX02‐Na was first used to reduce the cell viability of human non–small cell lung cells A549, which was confirmed by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay. Flow cytometry and Western blot analysis showed that ZYX02‐Na could lead to cell cycle arrest in G0/G1 phase, which demonstrated that ZYX02‐Na inhibited the proliferation of A549 cells. Furthermore, the AMPK/mTOR/4E‐BP1 signaling pathway was activated in ZYX02‐Na‐treated A549 cells. Besides, wounding healing and transwell experiments showed that ZYX02‐Na could also inhibited the migration ability of A549 cells. Moreover, we also found that ZYX02‐Na could induce autophagy of A549 cells by acridine orange staining, GFP‐LC3 subcellular localization observation and Western blotting analysis, respectively. In short, our current studies indicated that ZYX02‐Na possessed the antiproliferation effect and autophagy induction on A549 cells, while in vivo anticancer study of ZYX02‐Na needs to be done in future.
Application of the unified theory of acceptance and use of technology model to predict dental students’ behavioral intention to use teledentistry
Authors: Alabdullah Jafar H. , Van Lunen Bonnie L. , Claiborne Denise M. , Daniel Susan J. , Yen Cherng‐Jyh , Gustin Tina S. 
Published: July 2020

AbstractTeledentistry is an innovative technology that can be used to improve access to care and oral health outcomes. Dental students’ intention to use teledentistry after completing dental school has not been investigated.PurposeThe unified theory of acceptance and use of technology (UTAUT) was used to predict intentions to use teledentistry among 4th‐year U.S. dental students.MethodsA cross‐sectional approach was performed for a 7‐week period in Spring 2019. All U.S. dental schools (N = 66) were invited to participate and 16 schools agreed to participate. An anonymous survey link was emailed to academic deans for dissemination to students. A total of 1416 4th‐year dental students received the anonymous survey link and 210 students completed the survey (response rate = 14.8%). The survey included questions and scales that measured the UTAUT constructs of performance expectancy (PE), effort expectancy (EE), social influence (SI), facilitating conditions (FC), and behavioral intentions (BI). Data were analyzed using SPSS version 24. The study was deemed exempt by institutional review board.ResultsThe dental students’ BI to use teledentistry was significantly predicted by PE (R2 = 33%, P < 0.01), EE (R2 = 24%, P < 0.01), SI (R2 = 24%, P < 0.01), and FC (R2 = 14%, P < 0.01). The UTAUT model was statistically significant in predicting the BI and explained 40% of BI variance (R2 = .40, P < 0.01).ConclusionsDental students’ perceptions about PE, EE, SI, and FC were associated with BI. Therefore, exposure to teledentistry while in dental school could increase the likelihood of use as a practicing provider.
Changes in genetic variant results over time in pediatric cardiomyopathy and electrophysiology
Authors: Cherny Sara , Olson Rachael , Chiodo Kathryn , Balmert Lauren C. , Webster Gregory 
Published: July 2020

AbstractGenetic testing for cardiac disorders continues to change. Our objective was to assess trends in variant classification in pediatric arrhythmia and cardiomyopathy. We conducted a retrospective review of patients tested for genetic arrhythmia and cardiomyopathy disorders from 2006–2017. Variants were classified by CLIA laboratories. Trends were assessed by the Spearman correlation. There were 914 variants in 583 patients from 337 families. The total number of tests ordered increased over time, accelerating after 2012. There was a strong positive correlation between the average number of genes tested per panel and year of testing (r = .97, p < .001) and a weak correlation between the year and a decrease in the percentage of clinically actionable variants (r = −.20, p = .005). By 2011, VUS represented >50% of variants reported on panels. Over 12 years, 203 genes were interrogated; one or more variants were reported in 91 of 203 genes (45%). 32% of patients had at least one clinically actionable variant; 28% had at least one VUS. Reclassification is an important long‐term issue, with 21.5% variants changing clinical interpretation. We observed an increase over time in three areas: total number of tests ordered, average number of genes/panel, and percentage of VUS. Providers may need to interpret results from 90 + genes, and ongoing education is critical. Due to their specific training in test result interpretation, we recommend the inclusion of a genetic counselor in pediatric electrophysiology and cardiomyopathy teams.
Synthesis, characterization, and antimicrobial evaluation of some novel anthracene heterocycles derivatives
Authors: Dardeer Hemat M. , Taha Ahmed G. , Elamary Rokaya B. 
Published: July 2020

AbstractA series of novel heterocyclic compounds containing anthracene moiety was synthesized. Reaction of (11R,15S)‐9,10‐dihydro‐9,10‐[3,4]furanoanthracene‐12,14‐dione with 2‐cyanoacetohydrazide gave 2‐cyano‐pyrroloanthracen acetamide (1), which acts as an adaptable material for the synthesis of new heterocyclic compounds. The synthesized compounds were examined for their antimicrobial activity against Escherichia coli and Staphylococcus aureus via p‐iodonitrotetrazolium violet formazon assay. The results exhibited great activity against the tested strains with a minimum bactericidal concentration range from 0.636 to 3.8 mg/mL) and 0.159 to 3.6 mg/mL for E coli and S aureus, respectively. Interestingly, the highest activity was recorded for chromene derivative (6) against both strains.
Need, Merit, Self‐Interest or Convenience? Exploring Aid Allocation Motives of Grassroots International NGOs
Authors: Davis John‐Michael , Swiss Liam 
Published: July 2020

AbstractDespite substantial scholarly attention given to aid allocation motives of state agencies and professionalized non‐governmental organizations (NGOs), privately funded grassroots international NGOs (GINGOs), which have rapidly emerged in the global North, have escaped academic analysis. Using an original dataset of 948 Canadian NGOs, this study compares country aid allocation patterns along competing variables of need, merit, self‐interest and convenience between professionalized, mid‐sized independent and grassroots international NGOs. Our results underscore the importance of a disaggregated analysis yet reveal similar aid allocation trends between all three NGO groups and show significant herding behaviour. These findings question the added value of the growing phenomena of GINGOs. © 2020 John Wiley & Sons, Ltd.
Effects of different concentrations of coated nano zinc oxide material on fecal bacterial composition and intestinal barrier in weaned piglets
Authors: Liu Hongnan , Bai Miaomiao , Xu Kang , Zhou Jian , Zhang Xiaofeng , Yu Rong , Huang Ruilin , Yin Yulong 
Published: July 2020

AbstractBACKGROUNDCoated nano zinc oxide (Cnz) is a new feed or food additive, which is a potential replacement for a pharmacological dose level of ZnO. This study evaluated the positive effects of different concentrations of Cnz on the intestinal bacterial core, enterobacterial composition and mucosal barrier function in a pig model.RESULTSMicrobiota sequencing results showed that Cnz could significantly alter the intestinal microbiota composition and metabolism. Besides increasing the richness indices (ACE and Chao1), 10% Cnz could protect the intestinal mucosal barrier through increasing the expression of occludin and zonula occludens‐1 in the small intestine, increase the abundance of Lachnospiraceae UCG‐004 and decrease the abundance of Ruminococcus flavefaciens compared to high ZnO diet and 5% Cnz material.CONCLUSIONSCnz material at 10% supplementation is more effective than a level of 5% Cnz in increasing intestinal barrier through affecting gut microbiota. © 2020 Society of Chemical Industry
Near‐infrared dye‐labeled antibody COC183B2 enables detection of tiny metastatic ovarian cancer and optimizes fluorescence‐guided surgery
Authors: Chen Junchen , Guo Yanxiu , Li Hui , Zhang Chen , Chang Xiaohong , Ma Ruiqiong , Cheng Hongyan , Ye Xue , Cui Heng , Li Yi 
Published: July 2020

AbstractObjectiveWe aimed to evaluate the ability of the fluorescent monoclonal antibody probe COC183B2‐Cy7 (Cy7‐conjugated COC183B2 antibody) to detect tiny metastatic lesions of ovarian cancer and thus guide precise tumor resection.MethodsThe expression of the tumor‐associated antigen OC183B2 in lymph nodes and SKOV3‐Luc cells was detected using immunohistochemistry and immunofluorescence. A subcutaneous mouse tumor model and an intraperitoneal ovarian cancer metastasis model were constructed using SKOV3‐Luc cells. Near‐infrared fluorescence (NIRF) imaging was performed to determine the imaging parameters and evaluate the ability of COC183B2‐Cy7 to detect tiny metastatic lesions.ResultsOC183B2 was expressed in metastatic lymph nodes and SKOV3‐Luc cells. NIRF imaging of the subcutaneous mouse tumor model showed that the tumor background ratio was significantly higher in the COC183B2‐Cy7 group than in the control group at different time points postinjection. Biodistribution study showed that COC183B2‐Cy7 did not accumulate in other organs. COC183B2‐Cy7 can detect tiny metastatic lesions of ovarian cancer. The smallest intraperitoneal metastatic tumor detected by COC183B2‐Cy7 was approximately 1 mm.ConclusionsCOC183B2‐Cy7 probe has relatively high specificity and sensitivity. Our study suggests that COC183B2‐Cy7 probe is a promising diagnostic tool for the complete and accurate resection of malignant lesions in fluorescence‐guided surgery.
Preparation of 2‐amino‐2‐hydroxymethyl‐1,3‐propanediol (TRIS) pHT buffers in synthetic seawater
Authors: Paulsen May‐Linn , Dickson Andrew G. 
Published: July 2020

AbstractBuffers of known quality for the calibration of seawater pHT measurements are not widely or commercially available. Although there exist published compositions for the 0.04 mol kg‐H2O−1 equimolar buffer 2‐amino‐2‐hydroxymethyl‐1,3‐propanediol (TRIS)‐TRIS · H+ in synthetic seawater, there are no explicit procedures that describe preparing this buffer to achieve a particular pHT with a known uncertainty. Such a procedure is described here which makes use of easily acquired laboratory equipment and techniques to produce a buffer with a pHT within 0.006 of the published pHT value originally assigned by DelValls and Dickson (1998), 8.094 at 25°C. Such a buffer will be suitable for the calibration of pH measurements expected to fulfil the “weather” uncertainty goal of the Global Ocean Acidification Observation Network of 0.02 in pHT, an uncertainty goal appropriate to “identify relative spatial patterns and short‐term variation.”
pH‐Triggered Self‐Assembly of Cellulose Oligomers with Gelatin into a Double‐Network Hydrogel
Authors: Hata Yuuki , Kojima Tomoya , Maeda Tohru , Sawada Toshiki , Serizawa Takeshi 
Published: July 2020

AbstractMulticomponent systems for self‐assembled molecular gels provide huge opportunities to generate collective or new functions that are not inherent in individual single‐component gels. However, gelation tends to require careful and complicated procedures, because, among a myriad of kinetically trapped structures related to the degree of mixing of multiple components over a wide range of scales, from molecular level to macroscopic scale, a limited number of structures that exhibit the desired function need to be constructed. This study presents a simple method for the construction of double‐network (DN) hydrogels with improved stiffness composed of crystalline cellulose oligomers and gelatin. The pH‐triggered self‐assembly of cellulose oligomers leads to the formation of robust networks composed of crystalline nanofibers in the presence of dissolved gelatin, followed by cooling to allow for the formation of soft gelatin networks. The resultant DN hydrogels exhibit improved stiffness; the improvement in gel stiffness with double networking is comparable to that of previously reported DN hydrogels produced via a time‐consuming enzymatic reaction.