bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on porous titanium implants and its animal experiments
Authors: Yao Chunyan , Chen Dongdong , Zheng Zhongli , Wang Qiangsheng , Fu Kaijie 
Published: December 2020

Purpose
The purpose of this study is to obtain an effective implant with porous structures on its surface, named porous-surfaced implant, which helps to improve the overall stability of the implant and promote the combination of implant and alveolar bone.

Design/methodology/approach
Porous-surfaced implants with a porosity of 16%, 21%and 32% were designed and the effect of porosity on the strength of the implant was analyzed by ABAQUS software. Porous-surfaced implants with different porosity were printed by selective laser melting and the surface morphology was observed. Animal experiments of implants with porous structures and coating were carried out in healthy beagle dogs. The experimental group was treated with hydroxyapatite coating and the control group was not treated. Bone volume (BV) and total volume (TV) of the implant surface of the experimental group and control group were calculated by Skyscan CTvol software.

Findings
With the increase of porosity of porous-surfaced implants, the neck stress of the porous-surfaced implants increased and their strength decreased. In addition, in animal vivo experiments, the ratio value of BV to TV of the porous-surfaced implants was between 55.38% and 79.86%, which was the largest when the porosity of porous-surfaced implants was 16%. The internal and surrounding bone formation content of porous-surfaced implants with hydroxyapatite coating was higher than porous-surfaced implants without coating.

Originality/value
The results of this study show that the pores on the surface of implants can be filled with the new bone and porous-surfaced implants with 16% porosity provide better space for the growth of new bone. The porous structures with hydroxyapatite coating are beneficial to the growth of new bone around implants. The results of this study are helpful to improve the overall stability of implants and to promote the combination of implant and alveolar bone.
Total eclipse on business performance and mass personalization: how supply chain flexibility eclipses lean production direct effect
Authors: Maqueira Juan Manuel , Novais Luciano Romualdo , Bruque Sebastian 
Published: December 2020

PurposeThis paper aims to analyze the mediating role of Supply Chain Flexibility on the interrelationships binding Lean Production implementation, Mass Personalization and business performance.Design/methodology/approachA random sample of 260 companies obtained from a population of 1,717 Spanish companies that occupy an intermediate position in the supply chain has been used to test the proposed hypothetical framework. Telephone surveys using a computerized system have been used to collect data, obtaining a response rate of 15.6 and a structural equation model has been designed to test the six proposed hypotheses.FindingsCompanies initially implement Lean Production to optimize Mass Personalization processes and improve business performance. However, in the presence of Supply Chain Flexibility, Lean Production implementation no longer has a direct impact on Mass Personalization and business performance, but it does have an indirect impact through the flexibility it achieves (shown as a total mediating path). Therefore, companies should implement Lean Production to achieve flexibility and thus optimize the Mass Personalization processes and obtain better performance.Originality/valueAcademics and business managers may have supporting evidence on the role played by the total mediating effect of Supply Chain Flexibility on the relationship between Lean Production, Mass Personalization and business performance. A better knowledge of these management resources and their relationship could affect the way researchers and practitioners approach them, becoming more aware of the important role of the supply chain in competitiveness.
A study on key lean enablers of the coal mining sector using ISM, MICMAC and SEM
Authors: Khaba Sorokhaibam , Bhar Chandan , Ray Ankita 
Published: December 2020

PurposeThe purpose of this research is to identify and study the contextual relationships of the significant lean enablers in the Indian coal mining industry using the application of interpretive structural modeling (ISM), matrice d' impacts croisés-multiplication appliquée á un classement (MICMAC) and structural equation modeling (SEM).Design/methodology/approachIn this study, a conceptual model based on ISM was developed forming a hierarchy and contextual relationships of significant enablers for lean implementation in the Indian coal mining industry using a literature review and eliciting expert opinion, which is followed by MICMAC for grouping of enablers and questionnaire survey to validate the ISM based conceptual model using SEM.FindingsThe study modeled and analyzed ten significant enablers of lean implementation in the Indian coal mining industry. The findings suggest that the most important lean enablers in the Indian coal mining industry are employee empowerment, employee motivation and commitment, consistent financial performance measurement and management support.Research limitations/implicationsJudgmental sampling was used for selecting the respondents for conducting the questionnaire survey in this research work as there are a few numbers of coal mines implementing lean principles in India. Although the study was not restricted to a particular part of India with the sample representing the heterogeneous population, the study represents more data from the coal mines in eastern India.Practical implicationsThe model on lean enablers would help the researchers, decision-makers and practitioners to anticipate potential lean enablers in the Indian coal mines and rank the enablers for improved and efficient usage of the available resources creating value to customers with lean and to sustenance academic research on lean.Originality/valueStudies on lean enablers in the mining sector are scarce in the literature, and this study is a novel contribution of exploring lean enablers in the Indian coal mining industry using an integrated approach of ISM–MICMAC and SEM.
The ‘Chimera’ of Parenthood
Authors: Sloan Brian 
Published: December 2020

AbstractIn apparently the first reported instance of a paternity test being ‘fooled’ by a ‘human chimera’, a man ‘failed’ a paternity test because the genetic material in his saliva was shown to be different from that in his sperm. Such a chimera has extra genes, here absorbed from a twin lost in early pregnancy. The result was that the 'true' genetic father of the man's son was the twin, who had never been born. Chimeras present a challenge to legal systems, given the frequent emphasis on genetics in determining parenthood. This paper considers the phenomenon's potential implications for English law's understanding of parenthood. It advocates the recognition of the chimeric person as the ‘true’ legal father and suggests two methods through which this might be accomplished, pointing out their broader consequences. The paper also explores English law's likely practical response to the situation of a potential chimera.
Novel cheese with vegetal rennet and microbial transglutaminase: Effect of storage on consumer acceptability, sensory and instrumental properties
Authors: García‐Gómez Belén , Vázquez‐Odériz Mª Lourdes , Muñoz‐Ferreiro Nieves , Romero‐Rodríguez Mª Ángeles , Vázquez Manuel 
Published: December 2020

The aim of this study was to evaluate the consumer acceptance and preference of a novel cheese coagulated with vegetal rennet and microbial transglutaminase (V + TG) as an alternative for lacto‐vegetarian consumers. The evolution of the sensory and instrumental parameters throughout the storage time was studied. Cheese with animal rennnet and microbial transglutaminase (A + TG), vegetal rennet alone (V) and animal rennet alone (A) were also studied as controls. The consumer test showed that the V + TG cheese was preferred and showed high texture and taste acceptance scores. This cheese could be successful for its sensory acceptance and as an alternative for the lacto‐vegetarian market.
Effect of blanching and freezing on the physical properties, bioactive compounds, and microstructure of garlic (Allium sativum L.)
Authors: Zhang Bin , Qiu Zhichang , Zhao Ruixuan , Zheng Zhenjia , Lu Xiaoming , Qiao Xuguang 
Published: December 2020

AbstractThe aim of this work was to evaluate the impact of blanching on the physical properties of frozen garlic cloves and to explore the relationship between quality changes and microstructure. A short‐term blanching treatment (100 °C for 45 s, 90 °C for 45 s, and 80 °C for 60 s) before freezing did not affect the total organosulfur compound content. In a preliminary research, blanching conditions were determined to be 100 °C for 45 to 80 s. Under these conditions, peroxidase was inactivated, but organosulfur compounds were retained. Mechanical and color tests showed a damaging effect of blanching and freezing on frozen garlic blanched for 60 and 80 s at 100 °C . Compared to frozen fresh garlic, frozen garlic treated by blanching for 45 s at 100 °C retained 2871.49 ± 200.24 µg/g of allicin, although 81.83% of peroxidase was inactivated; browning and hardness improved by 49.97 and 48.01%, respectively. According to scanning electron microscopy, significant damage to the microstructure was observed in both frozen fresh garlic and frozen garlic after 60 s and 80 s of blanching at 100 °C . Moreover, 1H low‐field nuclear magnetic resonance (LF‐NMR) indicated that blanching for 60 s and 80 s induced an increase in free water in garlic tissues, resulting in further damage after freezing. As peroxidase was efficiently inactivated, the microstructure and organosulfur compounds were better preserved, and blanching treatment at 100 °C for 45 s before freezing is a potential method for obtaining frozen garlic with high sensory and nutritional qualities.Practical ApplicationFreezing helps to overcome challenges associated with growing seasons and the deterioration of garlic during storage. After frozen garlic is thawed, it is prone to some undesirable changes, such as enzymatic browning and softening. Minimal blanching (45 s at 100 °C ) pretreatment can help to maintain the bioactive compounds of garlic and prevent texture and color deterioration caused by freezing directly.
Genetic variants of ABCC8 and phenotypic features in Chinese early onset diabetes
Authors: Li Meng , Gong Siqian , Han Xueyao , Zhang Simin , Ren Qian , Cai Xiaoling , Luo Yingying , Zhou Lingli , Zhang Rui , Liu Wei , Zhu Yu , Zhou Xianghai , Sun Yanfang , Li Yufeng , MA Yumin , Ji Linong 
Published: December 2020

AbstractBackgroundABCC8 variants cause neonatal diabetes, maturity onset diabetes of the young (MODY), and hyperinsulinemic hypoglycemia because of activating or inactivating variants. In this study we used targeted exon sequencing to investigate genetic variants of ABCC8 and phenotypic features in Chinese patients with early onset diabetes (EOD).MethodsA cross‐sectional study of 543 Chinese patients with EOD was recruited and the exons of them were conducted targeted sequencing. The pathogenicity of ABCC8 variants was defined according to the American College of Medical Genetics and Genomics and the Association for Molecular Pathology guideline. The phenotypes of patients owing to ABCC8 variants (ABCC8‐MODY) were characterized.ResultsAmong the 543 participants, eight (1.5%) patients with ABCC8‐MODY were identified. They harbored eight missense ABCC8 variants (p.R306C, p.E1326K, and p.R1379H, previously reported; p.R298C, p.F1176C, p.R1221W, p.K1358R, and p.I1404V) classified as likely pathogenic. Two family members with ABCC8‐MODY were also confirmed. The average diagnosed age of the 10 patients was 26.8 ± 12.9 years. The majority of them had unsatisfactory glucose control, 80% of them had diabetic kidney disease, and neurological features were not observed.ConclusionUsing targeted exon sequencing followed by pathogenicity analysis, we could be able to make genetic diagnoses for eight (1.5%) patients with ABCC8‐MODY. The phenotype was variable with higher risk of diabetic microvascular complications. Genetic diagnosis is conducive for facilitating the personalized treatment of ABCC8‐MODY.
Ca. 1.7 Ga Magmatism on Southwestern Margin of the Yangtze Block: Response to the Breakup of Columbia
Authors: GENG Yuansheng , DU Lilin , KUANG Hongwei , LIU Yongqing 
Published: December 2020

AbstractThis paper presents some data of the Jiaopingdu gabbro and Caiyuanzi granite at the southwestern margin of the Yangtze Block, on the geochemical compositions, zircon LA–ICP–MS U–Pb ages and Hf isotopic data. The Jiaopingdu gabbro gives the age of 1721 ± 5 Ma, the Caiyuanzi granite 1732 ± 6 Ma and 1735 ± 4 Ma, and the Wenjiacun porphyry granite 1713 ± 4 Ma, suggesting nearly contemporaneous formation time of the gabbro and granite. The bimodal feature is demonstrated by the gabbro SiO2content of 44.64–46.87 wt% and granite 73.81–77.03 wt%. In addition, the granite has high content of SiO2and Na2O + K2O, low content of Al2O3and CaO, enriched in REEs (except Eu) and Zr, Nb, Ga and Y, depleted in Sr, implying it belongs to A‐type granite geochemistry and origin of within‐plate environment. The zircon∊Hf(t) of the granite and gabbro is at the range of 2–6, which is near the 2.0 Ga evolution line of the crust, implying the parent magma of the gabbro being derived from the depleted mantle and a small amount of crustal material, and the parent magma of the granite from partial melting of the juvenile crust and some ancient crustal material at the same time. Compared with 1.8–1.7 Ga magmatism during breakup of other cratons in the world, we can deduce that the Columbia has initially broken sinceca. 1.8 Ga, and some continental marginal or intra‐continental rifts occurred atca. 1.73 Ga.
Genomic characteristics of driver genes in Chinese patients with non‐small cell lung cancer
Authors: Si Xiaoyan , Pan Ruili , Ma Shaohua , Li Lin , Liang Li , Zhang Ping , Chu Yuping , Wang Hanping , Wang Mengzhao , Zhang Xiaotong , Zhang Li 
Published: December 2020

AbstractBackgroundThe aim of this study was to determine the demographic profile of driver gene alterations, especially low‐frequency gene alterations in Chinese patients with non‐small cell lung cancer (NSCLC).MethodsA total of 7395 Chinese patients with NSCLC were enrolled in the study. Next‐generation sequencing (NGS) was performed on formalin‐fixed paraffin‐embedded specimens collected via either surgical resection or biopsy.ResultsThe frequent genomic alterations found in the study were EGFR mutations (51.7%), KRAS mutations (13.1%), MET alterations (5.6%; 3.2% copy number gains and 0.5% exon 14 skipping mutation), HER2 alterations (7.0%; 2.0% copy number gains and 5.4% mutations), ALK alterations (7.2%; 3.9% rearrangements), RET rearrangements (1.4%), ROS1 rearrangements (0.9%), and NTRK rearrangements (0.6%). The EGFR mutation rate was found to be significantly higher in women than in men (69.1% vs. 38.5%, P < 0.001), while the KRAS mutation (17.5% vs. 7.3%, P < 0.001) and MET alteration rates (6.5% vs. 4.5%, P < 0.001) were significantly higher in men than in women. The EGFR mutation rate tended to decrease with age in the group aged >40 years, while the KRAS mutation rate tended to increase with age. The HER2 mutation (13.9% vs. 6.7%, P < 0.001) and ALK alteration rates (14.3% vs. 6.9%, P < 0.001) were significantly higher in the group aged <40 years than in groups aged 40 years or older.ConclusionsThe frequency of different driver genes was diverse in different age‐gender groups, and the results of this study may assist clinicians in clinical decision‐making and the development of public healthcare strategies in the future.Key pointsSignificant findings of the study
This study demonstrated that the frequency of different driver genes was diverse in different age‐gender groups.
What this study adds
It may enable clinicians to make clinical decisions, and assist government, pharmaceutical researchers and insurance companies develop public healthcare strategies.
Lung ventilation distribution in patients after traditional full sternotomy and minimally invasive thoracotomy: An observational study
Authors: Zhao Zhanqi , Yuan Tsai‐Ming , Chuang Ya‐Hui , Wang Yu‐Wen , Chang Hou‐Tai , Bien Mauo‐Ying , Huang Jih‐Hsin , Lin Nian‐Jhen , Frerichs Inéz , Möller Knut , Fu Feng , Yang You‐Lan 
Published: December 2020

AbstractBackgroundThe aim of the study was to examine the post‐operative ventilation distribution changes in cardiac surgical patients after traditional full sternotomy (FS) or minimally invasive thoracotomy (MIT).MethodsA total of 40 patients scheduled for FS with two‐lung ventilation or MIT with one‐lung ventilation were included. Ventilation distribution was measured with electrical impedance tomography (EIT) at T1, before surgery; T2, after surgery in ICU before weaning; T3, 24 hours after extubation. EIT‐based parameters were calculated to assess the ventilation distribution, including the left‐to‐right lung ratio, ventral‐to‐dorsal ratio, and the global inhomogeneity index.ResultsThe global inhomogeneity index increased at T2 and T3 compared to T1 in all patients but only statistically significant in patients with MIT (FS, P = .06; MIT, P < .01). Notable decrease in the dorsal regions (FS) or in the non‐ventilated side (MIT) was observed at T2. Ventilation distribution was partially improved at T3 but huge variations of recovery progresses were found in all patients regardless of the surgery types. Subgroup analysis indicated that operation duration was significantly lower in the MIT group (240 ± 40 in FS vs 205 ± 90 minutes in MIT, median ± interquartile range, P < .05) but the incidence of atrial fibrillation/flutter was significantly higher (5% in FS vs 50% in MIT, P < .01). Other exploratory outcomes showed no statistical differences.ConclusionsVentilation distribution was impaired after cardiac surgery. The recovery process of ventilation homogeneity was strongly depending on individuals so that MIT was not always superior in this aspect. EIT may help to identify the patients requiring further care after surgery.
The effect of taper and apical preparation size on fracture resistance of roots
Authors: Doğanay Yıldız Ezgi , Fidan Mehmet Eren , Sakarya Rüştü Ersoy , Dinçer Buket 
Published: December 2020

AbstractThis study investigated the effect of taper and apical preparation size on the fracture resistance of roots. 84 mandibular incisor teeth were selected. Groups (n = 12): uninstrumented (control group), 25/0.04, 25/0.06, 25/0.08, 30/0.04, 30/0.06 and 30/0.08. K3XF files (Kerr Endodontics, Orange, CA) were used for canal preparation. Fracture resistance was tested using a Universal test machine. For statistical analysis, the level of significance was P ≤ 0.05, and one‐way anova and post hoc LSD tests were used. The control group showed the highest fracture resistance (P < 0.05). No significant difference was found between 25/0.04 and 25/0.06; 25/0.06 and 25/0.08; 30/0.04 and 30/0.06; 30/0.06 and 30/0.08; 25/0.04 and 30/0.04; 25/0.06 and 30/0.06; and 25/0.08 and 30/0.08 (P > 0.05). Significant differences were found between 25/0.04 and 25/0.08; 30/0.04 and 30/0.08; and 25/0.08 and 30/0.04 (P < 0.05). In conclusion, the clinical selection of larger tapers can cause a higher risk of fracture.
Evaluation of the mechanical properties of different nickel–titanium retreatment instruments
Authors: Weissheimer Theodoro , Heck Luana , Calefi Pedro Henrique Souza , Alcalde Murilo Priori , da Rosa Ricardo Abreu , Vivan Rodrigo Ricci , Duarte Marco Antonio Hungaro , Só Marcus Vinícius Reis 
Published: December 2020

AbstractThis study investigated the cyclic fatigue, bending, torsional resistance and angular deflection of Pro‐R 25.08, Logic RT 25.08, MK Retreatment 25.08 (MK RT) and ProTaper Retreatment D2 instruments. Cyclic fatigue test was performed until fracture in a custom stainless‐steel device with water bath equipment to simulate body temperature. Fracture time was recorded. A number of cycles were calculated. Resistance to bending at 45°, torsional resistance and angular deflection were evaluated. The fracture surfaces were examined by scanning electron microscopy. Statistical analysis was performed with one‐way ANOVA and Tukey and Kruskal–Wallis and Dunn tests. Pro‐R and Logic RT presented the highest cyclic fatigue (P < 0.05). D2 had higher strength to bend than Pro‐R and Logic RT (P < 0.05). Logic RT showed the highest torque and angular deflection (P < 0.05), without differences when compared to D2 (P > 0.05). Instrument performances were dependent on their geometrical features and heat treatments.
Cytokines in embryonic secretome as potential markers for embryo selection
Authors: Bahrami‐Asl Zahra , Hajipour Hamed , Rastgar Rezaei Yeganeh , Novinbahador Tannaz , Latifi Zeinab , Nejabati Hamid Reza , Farzadi Laya , Fattahi Amir , Nouri Mohammad , Dominguez Francisco 
Published: December 2020

AbstractDespite performing certain morphological assessments for selecting the best embryo for transfer, the results have not been satisfactory. Given the global tendency for performing quick and noninvasive tests for embryo selection, great efforts have been made to discover the predictive biomarkers of embryo implantation potential. In recent years, many factors have been detected in embryo culture media as a major source of embryo secretions. Previous studies have evaluated cytokines, miRNAs, extracellular vesicles, and other factors such as leukemia inhibitory factor, colony‐stimulating factor, reactive oxygen species, soluble human leukocyte antigen G, amino acids, and apolipoproteins in these media. Given the key role of cytokines in embryo implantation, these factors can be considered promising molecules for predicting the implantation success of assisted reproductive technology (ART). The present study was conducted to review embryo‐secreted molecules as potential biomarkers for embryo selection in ART.
Investigations and time trends in loop ileostomy reversals following anterior resections: a single Australian institution seven‐years' experience
Authors: Taylor Danielle , Besson Alex , Faragher Ian G. , Chan Steven T. F. , Yeung Justin M. 
Published: December 2020

AbstractBackgroundCurrently no consensus exists regarding what pre‐reversal investigations are required to assess integrity of the rectal anastomosis. The objective of this study was to compare pre‐reversal assessments of anastomotic integrity and to evaluate trends that might have influenced timings for reversal.MethodsFrom a prospectively maintained database, patients with colorectal cancer resections between March 2012 and October 2019 were identified. Patient characteristics, pre‐reversal contrast enema and flexible sigmoidoscopy findings were recorded, and management of complications were recorded. Time‐to‐ileostomy reversal and time series for trends were analysed.ResultsThere were 154 patients included. Pre‐reversal contrast enema or sigmoidoscopy detected a possible stricture or leak at the rectal anastomotic site in 11% (15/132) and 15% (18/112), respectively. When both modalities were used there was concordance of 86.1% and a positive likelihood ratio of 5.73. Of 125 (81.2%) ileostomies reversed, the median time‐to‐reversal was 11.99 months; time series analysis over the 7‐year period showed no significant trend for average patient‐days from booking to reversal (P = 0.60). Cox regression modelling did not identify any influential risk factors for the times taken to reversal.ConclusionThis study supports the use of both contrast enema and flexible sigmoidoscopy in the assessment of rectal anastomosis integrity. Most patients with complications can have their ileostomies reversed. Patients who have adjuvant chemotherapy have a prolonged time to reversal.