bluuebunny/crossref_metadata_2025_split huggingface dataset:
La importancia de la "experiencia-cliente"
Authors: Araya Guillermo A. 
Published: July 2020

Estoy esperando, lleno de ansiedad, el debut de la selección, después de 36 años. Repaso en mi mente un checklist: gaseosa, pop corn, sillón especial, nuevo tv de 60 pulgadas, conexión ultra HD, sonido 7.1. ¡Todo listo!
Pitazo inicial, rueda la pelota, primeros dos minutos y se va la señal de cable. No lo puedo creer, parece una pesadilla. Entonces llamo a la empresa que me da el servicio, me contesta una máquina que me pregunta el DNI; lo marco y luego una voz automatizada dice: si es cliente marque 1; si no es cliente marque 2. Marco rápido el 1, el tiempo apremia. Luego se escucha nuevamente esa voz automatizada, que no entiende que estoy apurado, e indica nuevas alternativas con una calma que exaspera. Solo quiero hablar con un humano, pero imposible, no está la alternativa. Aprieto 4, el número que corresponde a reclamos. Me aparece nuevamente la máquina y me dice que “estamos presentando problemas con la señal, pronto será reestablecida”. Al final la señal nunca llega y termino escuchando el partido por la radio.
Digitalización empresarial: una nueva adopción tecnológica
Authors: Armas Jimmy A. 
Published: July 2020

En los últimos años, las empresas han realizado con mayor rapidez una nueva adopción tecnológica debido a que están soportando una fuerte presión para la reducción de costos unitarios y una mayor competencia en el mercado, obligándose a ser más eficientes, productivas e innovadoras con el fin de cumplir sus objetivos de negocio. La digitalización empresarial consiste en proveer de un proceso de sustitución tecnológica, representada por la computación en la nube, big data, inteligencia artificial, aprendizaje automático e Internet de las cosas, que transforma los modelos de negocio; altera las cadenas de valor de los productos; y desvanece las fronteras que separan a las industrias entre sí. Pero no sólo se trata de adquirir nuevas tecnologías, sino emplearlas para innovar y rediseñar nuevos modelos de negocio incluyendo, un cambio cultural en la organización. La digitalización empresarial no es un proyecto con fecha de caducidad y que solo involucra a los departamentos de marketing o tecnología. La digitalización trata de un trabajo en equipo; de interiorizar; y de aplicar una mentalidad digital en todos los aspectos posibles.
Faktor yang Mempengaruhi Penilaian Terhadap Penurunan Tingkat Kunjungan Pasien di Instalansi Rawat Jalan
Authors: Utami Lia Wahyu , Purwaningsih Purwaningsih , Ni'mah Lailatun 
Published: July 2020

Pendahuluan: Jumlah kunjungan pasien umum di instalansi rawat jalan selama 3 bulan terakhir mengalami penurunan yang signifikan. Sehingga pendapatan rumah sakit berkurang. Tujuan penelitian ini untuk mengetahui faktor penurunan kunjungan pasien rawat jalan.Metode: Penelitian ini merupakan penelitian observasional dengan pendekatan cross-sectional. Populasi dalam penelitian ini adalah pasien umum yang berkunjung di Instalansi rawat jalan sebanyak 100 responden dengan tehnik pengambilan sampel dengan tehnik consecutive sampling. Kriteria inklusi yang ditetapkan adalah pasien umum yang dapat berkomunikasi dengan baik; pasien umum yang berobat di Intalansi Rawat Jalan; pasien tidak buta huruf; pasien umum dengan kesadaran baik; dan pasien dengan kriteria umur >13 tahun, jika pasien masih direntang 13-17 tahun diisikan oleh orang tua, sedangkan kriteria eksklusi yaitu pasien rawat jalan dengan penurunan kesadaran. Variabel independent dalam penelitian ini meliputi karakteriktis pasien rawat jalan yang berkunjung di Instalansi Rawat Jalan. Sedangkan variable dependent di dalam penelitian ini adalah penilaian pasien terhadap faktor provider yang meliputi petugas (attitutude, knowledge, dan practice), sarana dan prasarana, tarif, dan alur pendaftaran berdasarkan penilaian segitiga pelayanan. Penelitian ini menggunakan analisa deskritif dengan menggunakan tabel distributive frekuensi.Hasil: Hasil menunjukan bahwa penilaian antara strategi, sistem dan sumber daya manusia atas penilaian faktor provider yang meliputi tarif, petugas, alur pendaftaran, dan sarana dan prasarana. Dari segi petugas, tarif, alur pendaftaran mendapatkan penilaian baik sebanyak >75%. Sedangkan di sarana dan prasarana penilaian baik >75% terdapat di ruang tunggu, sedangkan di ruang rawat jalan dan periksa penilaian tidak baik mencapai 54% dan 61%.Kesimpulan: Faktor penyediaan sarana dan prasarana (Provider) sangat mempengaruhi kunjungan dari pasien umum di instalansi rawat jalan. Diharapkan pada penelitian selanjutnya diharapkan dapat menemukan pembaharuan atau aplikasi berbasis Android Operating System atau Iphone Operathing System yang dapat digunakan sebagai pengingat dan monitoring jadwal pasien untuk berkunjung ke rumah sakit
Sistematic Review: Bagaimana Cara Meningkatkan Caring Perawat
Authors: Anitarini Fany , Dwiantoro Luky , Santoso Agus 
Published: July 2020

Introduction: Nursing as a profession is demanded to develop science as a form of concern in order to maintain and improve the patient's health status. In the center of nursing practice, this is one of the dynamic nursing performance approaches called caring behavior. Efforts to implement caring behavior of course nurses must have good emotional intelligence, because it can improve patient satisfaction. Systematic Review aims to systematically review emotional intelligence for nurse caring behavior.Method: Literature search starting from 2012 - 2017 using the keywords Emotional Intelligence and Caring nurses. From the search found nine journals and five analyzed journals related to the theme. Search is done on the EBSCOhost, Elsevier, Sciencedirect and Google Scholar sites.Results: The results of the literature review found that one's caring behavior can be influenced by emotional intelligence that is possessed by someone. Where the higher the emotional intelligence the better the caring behavior.Conclusion: Emotional intelligence can help someone to understand the emotions of themselves and others in helping shape behavior.
Detection of Blood Protozoa Infecting Broiler Chicken Farms in Tanjung Gunung Village, District Jombang
Authors: Arifiandani Marchelia , Suprihati Endang , Yuniarti Wiwik Misaco , Lastuti Nunuk Dyah Retno , Hastutiek Poedji , Warsito Sunaryo Hadi 
Published: July 2020

Broiler chicken farms could be a part of potential source infection Leucocytozoonosis and Plasmodiosis disease due to the death of livestock. Broiler farms in Tanjung Gunung, District Jombang near the fields, water, and trees. This could be increase the population of vectors infection Leucocytozoonosis and Plasmodiosis. The main purpose of this researchis to detect Leucocytozoonosis and Plasmodiosis infections on broiler farms in Tnjung Gunung Village, District Jombang using 50 broiler chickens by Purposive Sampling of 2 bredeers. The result show rhat there are 6 positive samples infected Leucocytozoonosis, while Plasmodiosis infection could not be fond. Need cage sanitation to break life cycles of vector Leucocytozoonosis and Plasmodiosis.
Rekayasa dan Penguatan Lembaga Menghadapi Persaingan Global Berbasis Wirausaha dan Etika Islam
Authors: Madjakusumah Deden Gandana , Saripudin Udin , Suryani Suryani 
Published: July 2020

Abstract: The economic trends of countries in the world tend to lead to globalization and several countries that have a common interest in forming a global place in a narrower or regional scope such as AFTA, APEC, NAFTA, and so on are the efforts of countries that are members of these organizations. to be able to compete in the global economy. This paper aims to elaborate the concept of engineering and strengthening of entrepreneurial institutions and Islamic ethics in order to face the era of the global market. This study uses the literature study method, namely by studying various sources and literature related to institutional strengthening, entrepreneurship, and Islamic ethics. The results of the study concluded that organizational development as an engineering and strengthening of institutions to improve global competitiveness based on entrepreneurship and Islamic ethics can be an alternative solution for government, private and community institutions in facing competition between institutions that demand that each institution can have a competitive advantage and make values entrepreneurship and Islamic ethics as a basis in Engineering and Strengthening Institutions to enhance global competitiveness.Abstrak: Tren perekonomian negara-negara di dunia cenderung mengarah kepada globalisasi dan beberapa negara yang memiliki kesamaan kepentingan membentuk satu tempat global pada ruang lingkup yang lebih sempit atau regional seperti AFTA, APEC, NAFTA, dan sebagainya merupakan upaya dari negara-negara yang tergabung dalam organisasi tersebut untuk tetap dapat bersaing dalam kancah perekonomian global. Tulisan ini bertujuan untuk mengelaborasi konsep rekayasa dan penguatan lembaga berbasis kewirausahaan dan etika Islam dalam rangka menghadapi era pasar global. Kajian ini menggunakan metode kajian pustaka, yakni dengan mempelajari berbagai sumber dan literature yang terkait dengan penguatan lembaga, kewirausahaan, dan etika Islam. Hasil kajian menyimpulkan bahwa pengembangan organisasi sebagai rekayasa dan penguatan lembaga untuk meningkatkan daya saing global berbasis wirausaha dan etika Islam dapat menjadi alternatif solusi bagi lembaga-lembaga pemerintahan, swasta dan masyarakat dalam menghadapi persaingan antar lembaga yang menuntut setiap lembaga dapat memiliki keunggulan kompetitif dan menjadikan nilai-nilai wirausaha serta etika Islam sebagai basis dalam rekayasa dan penguatan lembaga untuk meningkatkan daya saing global.
QALY-Time: Experts’ View On The Use Of The Quality-Adjusted Life Year In Cost-Effectiveness Analysis In Palliative Care
Authors: Wichmann Anne B. , Goltstein Lia C.M.J. , Obihara Ndidi J. , Berendsen Madeleine R. , Houdenhoven Mark van , Morrison R. Sean , Johnston Bridget M. , Engels Yvonne 
Published: July 2020

Abstract
Background. The Quality-Adjusted Life Year (QALY) is internationally recognized as standard metric of health outcomes in cost-effectiveness analyses (CEAs) in healthcare. The ongoing debate concerning the appropriateness of its use for decision-making in palliative care has been recently mapped in a review. The aim was to report on and draw conclusions from two expert meetings that reflected on earlier mapped issues in order to reach consensus, and to advise on the QALY’s future use in palliative care. Methods. A nominal group approach was used. In order to facilitate group decision making, three statements regarding the use of the QALY in palliative care were discussed in a structured way. Two groups of international policymakers, healthcare professionals and researchers participated. Data were analysed qualitatively using inductive coding. Results. 1) Most experts agreed that the recommended measurement tool for the QALYs ‘Q’ component, the EuroQol-5D (EQ-5D), is inappropriate for palliative care. A more sensitive tool, which might be based on the capabilities approach, could be used or developed. 2) Valuation of time should be incorporated in the ‘Q’ part, leaving the linear clock time in the ‘LY’ component. 3) Most experts agreed that the QALY, in its current shape, is not suitable for palliative care. Conclusions. 1) Although the EQ-5D does not suffice, a generic tool is needed for the QALY. As long as no suitable alternative is available, other tools can be used besides or serve as basis for the EQ-5D because of issues in conceptual overlap. 2) Future research should further investigate the valuation of time issue, and how best to integrate it in the ‘Q’ component. 3) A generic outcome measure of effectiveness is essential to justly allocate healthcare resources. However, experts emphasized, the QALY is and should be one of multiple criteria for choices in the healthcare insurance package.
Drusen Characteristics of Type 2 Macular Neovascularization in Age-related Macular Degeneration
Authors: Ahmed Daniel , Stattin Martin , Haas Anna-Maria , Graf Alexandra , Krepler Katharina , Ansari-Shahrezaei Siamak 
Published: July 2020

Abstract
Background

To assess the relationship between drusen characteristics and type 2 macular neovascularization (MNV) in age-related macular degeneration (AMD)

Methods

Retrospective data analysis of eyes previously diagnosed with neovascular AMD in a tertiary eye care center (Medical Retina Unit, Rudolf Foundation Hospital, Vienna, Austria) between June 2008 and December 2017. Drusen subtypes, fibrosis, atrophy and subfoveal choroidal thickness (SFCT) of both eyes in patients with type 2 MNV lesions were categorized based on multimodal imaging.

Results

Type 2 MNV was diagnosed in 27 (3.2%) of 835 eyes (749 patients). Drusen characteristics in type 2 MNV were observed as followed: drusen < 63 mm in 2 eyes (7.4%), drusen ≥ 63 mm in 10 eyes (37%), subretinal drusenoid deposits (SDD) in 8 eyes (29.6%), cuticular drusen in 2 eye (7.4%) and no drusen were evident in 10 eyes (37%). Drusen distribution in 23 fellow eyes was detected as followed: drusen < 63 mm in 2 eyes (8.7%), drusen ≥ 63 mm in 9 eyes (39.1%), SDD in 5 eyes (21.7%), cuticular drusen in 1 eye (4.3%) and no drusen were evident in 9 eyes (39.1%). Mean SFCT was 140 ± 49 mm in affected eyes and 152 ± 41 mm in the fellow eyes. Patients with drusen or SDD were significantly younger (mean 70.88 ± 6.85, p=0.04) than patients without deposits (mean 77.40 ± 5.74).

Conclusions

Type 2 MNV remains a rare entity in AMD. It was frequently seen in the absence of drusen, a hallmark of AMD. These findings contribute to the heterogeneity of phenotypes related to pure type 2 lesions.
Geographic Availability To Optometry Services Across Canada: Mapping Distribution, Need And Self-Reported Use
Authors: Shah Tayyab , Milosavljevic Stephan , Bath Brenna 
Published: July 2020

Abstract
Background: This research investigates the distribution of optometrists in Canada relative to population health needs and self-reported use of vision services.Methods: Optometrist locations were gathered from provincial regulatory bodies. Optometrist-to-population ratios (i.e. the number of providers per 10,000 people at the health region level) were then calculated. Utilization of vision care services was extracted from the Canadian Community Health Survey (CCHS) 2013-2014 question regarding self-reported contacts with optometrists or ophthalmologists. Data from the 2016 Statistics Canada census were used to create three population ‘need’ subgroups (65 years and over; low-income; and people aged 15 and over with less than a high school diploma). Cross-classification mapping compared optometrist distribution to self-reported use of vision care services in relation to need. Each variable was converted into three classes (i.e., low, moderate, and high) using a standard deviation (SD) classification scheme where ± 0.5SD from the mean was considered as a cut-off. Three classes: low (< -0.5SD), moderate (-0.5 to 0.5SD), and high ( > 0.5SD) were used for demonstrating distribution of each variable across health regions. Results: A total of 5,959 optometrists across ten Canadian provinces were included in this analysis. The nationwide distribution of optometrists is variable across Canada; they are predominantly concentrated in urban areas. The national mean ratio of optometrists was 1.70 optometrists per 10,000 people (range = 0.13 to 2.92). Out of 109 health regions (HRs), 26 were classified as low ratios, 51 HRs were classified as moderate ratios, and 32 HRs were high ratios. Thirty-five HRs were classified as low utilization, 39 HRs were classified as moderate, and 32 HRs as high utilization. HRs with a low optometrist ratio relative to eye care utilization and a high proportion of key sociodemographic characteristics (e.g. older age, low income) are located throughout Canada and identified with maps indicating areas of likely greater need for optometry services.Conclusion: This research provides a nationwide overview of vision care provided by optometrists identifying gaps in geographic availability relative to “supply” and “need” factors. This examination of variation in accessibility to optometric services will be useful to inform workforce planning and policies.
Methotrexate impaired in-vivo matured mouse oocyte quality and the possible mechanisms
Authors: Tian Ning , Lv Dan-yu , Yu Ji , Ma Wan-yun 
Published: July 2020

Abstract
Background：Methotrexate (MTX) is an antifolate agent which is widely used in clinic for treating malignancies, rheumatoid arthritis and ectopic pregnancy. As reported, MTX has side effects on gastrointestinal system, nervous system and reproductive system, while its potential damages on oocyte quality are still unclear. It is known that oocyte quality is essential for healthy conception and the forthcoming embryo development. Thus, this work studied the effects of MTX on the oocyte quality. Results: We established MTX model mice by single treatment with 5 mg/Kg MTX. Both morphological and molecular biology studies were performed to assess the in-vivo matured oocytes quality and to analyze the related mechanisms. The in-vivo matured oocytes from MTX-treated mice had poor in-vitro fertilization ability, and the resulting embryo formation rates and blastocyst quality were lower than the control group. We found that the in-vivo matured MTX-treated mouse oocytes displayed abnormal transcript expressions for genes of key enzymes in the folate cycles. MTX increased the rate of abnormal chromosome alignment and affected the regulation of chromosome separation via disrupting the spindle morphology and reducing the mRNA expressions of MAD2 and Sgo1. MTX reduced the DNA methylation levels in the in-vivo matured oocytes, and further studies showed that MTX altered the expressions of DNMT1 and DNMT 3b, and may also affect the levels of the methyl donor and its metabolite. Conclusions: MTX impaired the in-vivo matured mouse oocyte quality by disturbing folate metabolism and affecting chromosome stability and methylation modification.
Oxytocin Use in Trial of Labor after Cesarean and Its Relationship with Risk of Uterine Rupture in Women with One Previous Cesarean Section: A Meta-analysis of Observational Studies
Authors: ZHANG Huan , LIU Haiyan , LUO Shouling , Gu Weirong 
Published: July 2020

Abstract
Background Trial of labor after a previous cesarean delivery (TOLAC) has reduced the rate of cesarean sections. Nevertheless, the widespread use of TOLAC has been limited by an increase in adverse outcomes, the most serious one being the risk of symptomatic uterine rupture, which is possibly associated with oxytocin. In this meta-analysis, we explored the risk association between oxytocin use and uterine rupture in TOLAC. Methods Multiple electronic databases were searched for cross-sectional studies reporting on TOLAC, oxytocin and uterine rupture, which were published between January 1986 and October 2019. The bias-corrected Hedge's g was calculated as the effect size using the random-effects model. A two-sample Z test was used to compare the differences in synthetic rates. The Newcastle-Ottawa Scale was used to evaluate the risk of bias.Results A total of 14 studies, which included 48457 women who underwent TOLAC, met the inclusion criteria. The pooled rate of vaginal birth after a cesarean section (VBAC) and the rate of uterine rupture in spontaneous labor were 74.3% and 0.7%, respectively. In addition, the pooled rate of VBAC and the rate of uterine rupture in the induction labor group was 60.7% and 2.2%, respectively. The women who had spontaneous labor had a significantly higher rate of VBAC (p=0.0032) and a lower rate of uterine rupture (p=0.0003) compared to induced labor. The pooled rates of uterine rupture in women using oxytocin and women not using oxytocin in TOLAC were 1.4% and 0.5%, respectively, and the difference was significant (p=0.0002). Also, the synthetic rate of uterine rupture in oxytocin augmentation among women with spontaneous labor and women who had a successful induction of labor were 1.7% and 2.2%, respectively, without significant difference (p=0.443). Conclusions Women with induced labor had a higher risk of uterine rupture compared to women with spontaneous labor following TOLAC. Oxytocin use may increase this risk, which could be influenced by the process of induction or individual cervix condition. Consequently, simplified and standardized intrapartum management, precise protocol, and cautious monitoring of oxytocin use in TOLAC are necessary.
Defective migration and dysmorphology of neutrophil granulocytes in atypical chronic myeloid leukemia treated with ruxolitinib
Authors: Bornemann Lea , Schuster Marc , Schmitz Saskia , Sobczak Charlyn , Bessen Clara , Merz Simon F. , Jöckel Karl-Heinz , Haverkamp Thomas , Gunzer Matthias , Göthert Joachim R. 
Published: July 2020

Abstract
Background The identification of pathologically altered neutrophil granulocyte migration patterns bears strong potential for surveillance and prognostic scoring of diseases. We recently identified a strong correlation between impaired neutrophil motility and the disease stage of myelodysplastic syndrome (MDS). Here, we apply this assay to study quantitively increased neutrophils of a patient suffering from a rare leukemia subtype, atypical chronic myeloid leukemia (aCML).Methods A 69-year-old male was analyzed in this study. Besides routine analyses, we purified the patient’s neutrophils from peripheral whole blood and studied their migration behavior using time-lapse video microscopy in a standardized assay. These live cell migration analyses also allowed for the quantification of cell morphology. Furthermore, the cells were stained for the markers CD15, CD16, fMLPR, CXCR1 and CXCR2. Results Despite cytoreductive therapy with hydroxyurea, the patient’s WBC and ANC were poorly controlled and severe dysgranulopoiesis with hypogranularity was observed. Neutrophils displayed strongly impaired migration when compared to healthy controls and migrating cells exhibited a more flattened-out morphology than control neutrophils. Because of a detected CSF3R (p.T618I) mutation and constitutional symptoms treatment with ruxolitinib was initiated. Within one week of ruxolitinib treatment, the cell shape normalized and remained indistinguishable from healthy control neutrophils. However, neutrophil migration did not improve over the course of ruxolitinib therapy but was strikingly altered shortly before a sinusitis with fever and bleeding from a gastric ulcer. Molecular work-up revealed that under ruxolitinib treatment, the CSF3R clone was depleted, yet the expansion of a NRAS mutated subclone was promoted. Conclusion These results demonstrate the usefulness of neutrophil migration analyses to uncover corresponding alterations of neutrophil migration in rare myeloid neoplasms. Furthermore, in addition to monitoring migration the determination of morphological features of live neutrophils might represent a useful tool to monitor the effectiveness of therapeutic approaches.