bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuromonitoring of Delirium with Quantitative Pupillometry in Sedated Mechanically Ventilated Critically Ill Patients
Authors: Favre Eva , Bernini Adriano , Morelli Paola , Pasquier Jerôme , Miroz John-Paul , Abed-Maillard Samia , Ben-Hamouda Nawfel , Oddo Mauro 
Published: December 2019

Abstract
Background. Intensive care unit (ICU) delirium is a frequent secondary neurological complication in critically ill patients undergoing prolonged mechanical ventilation. Quantitative pupillometry is an emerging modality for the neuromonitoring of primary acute brain injury, but its potential utility in patients at risk of ICU delirium is unknown. Methods. This was an observational cohort study of medical-surgical ICU patients, without acute or known primary brain injury, who underwent sedation and mechanical ventilation for at least 48 hours. Starting at day 3, automated infrared pupillometry – blinded to ICU caregivers – was used for repeated measurement of the pupillary function, including quantitative pupillary light reflex (q-PLR, expressed as % pupil constriction to a standardized light stimulus) and constriction velocity (CV, mm/sec). The relationship between delirium, using the CAM-ICU score, and quantitative pupillary variables was examined. Results. A total of 59/100 patients had ICU delirium, diagnosed at a median 8 days from admission. Compared to non-delirious patients, subjects with ICU delirium had lower values of q-PLR (25 [19-31] vs. 20 [15-28] %) and CV (2.5 [1.7-2.8] vs. 1.7 [1.4-2.4] mm/sec) at day 3, and at all additional time-points tested (p<0.05). After adjusting for the SOFA score and the cumulative dose of analgesia and sedation, lower q-PLR was associated with an increased risk of ICU delirium (OR 1.057 [1.007-1.113] at day 3; p=0.03). Conclusions. Sustained abnormalities of quantitative pupillary variables at the early ICU phase correlate with delirium and precede clinical diagnosis by a median 5 days. These findings suggest a potential utility of quantitative pupillometry in sedated mechanically ventilated ICU patients at high risk of delirium.
The association between FTO genotype and macro-nutrients’ intake in overweight adults
Authors: Mehrdad Mahsa , Doaei Saeid , Gholamalizadeh Maryam , Eftekhari Mohammad H 
Published: December 2019

Abstract
Background Macro-nutrients can influence on body weight through their interactions with FTO gene polymorphisms. This study aimed to investigate the association between FTO gene rs9939609 polymorphism with macro-nutrients intake.Methods This cross-sectional study was carried out on 196 overweight adults. The rs9939609 SNP in FTO was genotyped. Dietary intake was assessed by a valid 168-item semi-quantitative food frequency questionnaire (FFQ). The association between dietary macro-nutrients and the FTO genotype were assessed using linear regression after adjustments for sex, age, physical activity, triglycerides, fasting blood sugar (FBS), and low density lipoprotein (LDL).Results The higher carbohydrates (p=0.000), fat intake (p=0.009) and calorie intake (p=0.001) were significantly associated with FTO gene risk allele (P=0.001). Carriers of the AA/AG genotype of rs9939609 had significantly higher calorie, fat, and carbohydrate intake than the carriers of the TT genotype (p=0.019, p=0.010, & p=0.000, respectively).Conclusion The dietary carbohydrate and fat intake were associated with FTO genotype. Further studies are warranted to investigation of these interactions and the underlying mechanisms.
Retrospective analysis of salvage surgery for local progression of brain metastasis previously treated with stereotactic irradiation: diagnostic benefit, functional outcome, and prognostic factors
Authors: Mitsuya Koichi , Nakasu Yoko , Hayashi Nakamasa , Deduchi Shoichi , Oishi Takuma , Sugino Takashi , Yasui Kazuaki , Ogawa Hirofumi , Onoe Tsuyoshi , Asakura Hirofumi , Harada Hideyuki 
Published: December 2019

Abstract
BackgroundStereotactic irradiation (STI) is a primary treatment for patients with newly diagnosed brain metastases. Some of these patients experience local progression, which is difficult to differentiate from radiation necrosis, and difficult to treat. So far, just a few studies have clarified the prognosis and effectiveness of salvage surgery after STI. We evaluated the diagnostic value and improvement of functional outcomes after salvage surgery. Based on these results, we reconsidered surgical indication for patients with local progression after STI.MethodsWe evaluated patients with brain metastases treated with salvage surgery for local progression from October 2002 to July 2019. These patients had undergone salvage surgery based on magnetic resonance imaging findings and/or clinical evidence of post-STI local progression and stable systemic disease. We employed two prospective strategies according to the eloquency of the lesions. Lesions in non-eloquent areas had been resected completely with a safety margin, utilizing a fence-post method; while lesions in eloquent areas had been treated with minimal resection and postoperative STI. Kaplan-Meier curves were used for the assessment of overall survival. Prognostic factors for survival were analyzed.ResultsFifty-four salvage surgeries had been performed on 48 patients. The median age of patients was 63.5 years (range 36-79). The median interval from STI to surgery was 12 months. The median overall survival was 20.2 months from salvage surgery and 37.5 months from initial STI. Primary cancers were lung 31, breast 9, and others 8. Local recurrence developed in 13 of 54 lesions (24%). Leptomeningeal dissemination occurred after surgery in 3 patients (5.6%). Primary breast cancer (breast vs. lung: HR: 0.17), (breast vs. others: HR: 0.08) and RPA class 1-2 (RPA 1 vs. 3, HR:0.13), (RPA 2 vs 3, HR:0.4) were identified as good prognostic factors for overall survival (OS) in multivariate analyses. The peripheral neutrophil-to-lymphocyte ratio (NLR) of ≤3.65 predicted significantly longer OS (median 25.5 months) than an NLR >3.65 (median 8 months). Conclusion﻿We insist that salvage surgery leads to rapid improvement of neurological function and clarity of histological diagnosis. Salvage surgery is recommended for large lesions especially with surrounding edema either in eloquent or non-eloquent areas.
Comparison of 3-weekly cisplatin versus 3-weekly carboplatin in patients with locally advanced nasopharyngeal carcinoma receiving concurrent chemoradiotherapy: A multicentre analysis
Authors: Dechaphunkul Arunee , Danchaivijitr Pongwut , Jiratrachu Rungarun , Dechaphunkul Tanadech , Sookthon Chatsuda , Jiarpinitnun Chuleeporn , Paoin Chudchanok , Setakornnukul Jiraporn , Suktitipat Bhoom , Pattaranutaporn Poompis , Ngaimphaiboon Nuttapong 
Published: December 2019

Abstract
BackgroundAlthough concurrent chemoradiotherapy (CCRT) with high-dose cisplatin remains a standard of care for patients with locally advanced nasopharyngeal carcinoma (LA-NPC), carboplatin has alternatively been used, particularly for cisplatin-ineligible patients. However, the comparable efficacy of these two regimens remains unclear. The present study aimed to evaluate the efficacy and tolerability of 3-weekly carboplatin and 3-weekly cisplatin therapies.MethodsFrom May 2005 to November 2014, we identified patients with LA-NPC treated with CCRT from a Thai multicentre head and neck cancer database. The patients were administered a chemotherapy (CT) regimen of either cisplatin (75–100 mg/m2) or carboplatin (AUC-5 or 6). Patient tolerability and survival were analysed and compared between regimens.ResultsOverall, 780 patients with LA-NPC were identified. Of these, the 76 patients (9.7%) treated with carboplatin showed significantly more comorbidity and lower baseline creatinine clearance than those treated with cisplatin. Compared with the cisplatin group, a higher number of patients in the carboplatin group completed three planned cycles of CT during CCRT (88.2% vs 52.0%, p<0.001) and three planned cycles of adjuvant CT (92.1% vs 78.7%, p=0.004). Furthermore, 28% of patients in the cisplatin group, as opposed to only 2.8% in the carboplatin group, required a dose reduction of CT in the subsequent cycle due to toxicities (p<0.001). At the time of analysis, the 5-year disease-free survival rate was 59.0% and 59.0% (p=0.935) and the 5-year overall survival rate was 64.0% and 66.0% (p=0.530), in the cisplatin and carboplatin groups, respectively.ConclusionsCarboplatin provided comparable efficacy to that of cisplatin but with better tolerability and could be considered as an alternative regimen, particularly in cisplatin-ineligible patients with LA-NPC. These findings still warrant a randomised phase III study to compare these two CT regimens.
Effect of umbilical cord mesenchymal stem cells in human ovarian cancer SKOV3 cells
Authors: Lu Xiaoli , Liu Guangzhi , Cheng Lenan , Ge Licong , Zhao ZiYi , Yang Qiu yun 
Published: December 2019

Abstract
Objective:To investigate the effects of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) on apoptosis and proliferation of human ovarian cancer SKOV3 cells and to explore mechanism.Methods:hUC-MSCs were isolated and cultured by tissue block adherent culture method. The hUC-MSCs phenotype were identified by flow cytometry. The hUC-MSCs lysate and conditioned medium,directly combine were used to treat SKOV3 cells.The effects on the proliferation，apoptosis，mechanism of SKOV3 cells were examined by cell counting kit-8(CCK-8)，Annexin V-FITC/PI，quantitative real time polymerase chain reaction(RT-qPCR) and spheroid formation assays.Establish ovarian cancer xenograft models，1X 106 hUC-MSCs and 2 X 106 hUC-MSCs were administrated into the mice t rear back tumor tissue. After three injections of hUC-MSCs, the nude mice were sacrificed after 1 week of observation.Remove tumor tissue. Observed tumor volume changes every 3 days after the start of the experiment. The expression of CD34 and VEGF were detected by immunohistochemistry.Results:Human umbilical cord mesenchymal stem cells were cultured and isolated from tissue block. Flow cytometry results revealed that the hUC-MSCs marks CD44 and CD29, but not CD45 and CD34 were expressed on obtained cells. The apoptosis of SKOV3 cells was induced by hUC-MSCs lysate, conditioned medium and Transwell co-culture method in SKOV3 cells, and the apoptosis rate was higher with increasing concentration. hUC-MSCs conditioned medium and Transwell co-culture method can inhibit cell proliferation. After adding experimental factors, the conditioned medium and Transwell co-culture method can down-regulate the transcription of PI3KCA, AKT and BCL-2 genes in SKOV3 cells, and up-regulate the Caspase-3 gene.The tumor volume of the experimental group was smaller than that of the control group during the observation period. The expression levels of CD34 and VEGF in the experimental group were significantly lower than those in the control group(P<0.05).Conclusion: The conditioned medium of hUC-MSCs and the co-culture method of hUC-MSCs and SKOV3 can significantly inhibit the proliferation of SKOV3 cells, which is mainly achieved by inhibiting PI3K/AKT signaling pathway. hUC-MSCs can inhibit the growth of subcutaneous subcutaneous transplantation and the expression of CD34 and VEGF in ovarian cancer. It provides a new idea for the treatment of ovarian cancer.
Serum amyloid a, a potential biomarker both in serum and tissue, correlates with ovarian cancer progression
Authors: Li Ze , Hou Yongwang , Zhao Meng , Li Tianning , Liu YaHui , Chang Jiao , Ren Li 
Published: December 2019

Abstract
Objective: Ovarian cancer is the most fatal gynecologic malignancy worldwide due to delayed diagnosis as well as recurrence and drug resistance. Thus, a new type of ovarian cancer treatment prediction biomarker is urgently needed to supplement existing tools. Methods: One hundred patients operated on due to ovarian tumor were enrolled in this study. Meanwhile, one hundred ovarian benign patients and thirty healthy women were selected as control groups. Levels of SAA, CA125 and HE4 were assessed using standard laboratory protocols. 5 ovarian cancer tissues and paracancerous tissues were collected and than stored at -80℃ until the qRT-PCR assay was conducted.Results: The ROC curve of SAA concentration in ovarian cancer was plotted to obtain the area under the curve AUC = 0.889, the cut-off value 17.05 mg/L, the sensitivity 78.4% and specificity 86.5%. The results by logistic regression analysis revealed that there was significant correlation between the level of serum SAA and clinical stage and lymph node and distant metastasis. Compared with pre-treatment, the level of serum SAA decreased significantly after treatment. qRT-PCR assay revealed that the mRNA of SAA-1 and SAA-4 was much higher in cancer tissues than in adjacent tissues, and MMPs was up-regulation including MMP-1, MMP-9 and MMP- 12 in OVCAR-3 cell stimulated by SAA and transwell assay revealed that SAA could promote OVCAR-3 cell migration. Moreover, SAA can regulate EMT markers and promote Akt pathway activation.Conclusion: In summary, our results demonstrated that SAA may be a potential diagnosis and treatment prediction biomarker. SAA promote OVCAR-3 cell migration by regulating MMPs and EMT which may correlate with Akt pathway activation.
Exploration of Anti-inflammatory Mechanism of Forsythiaside A and Forsythiaside B in CuSO4-Induced Inflammation in Zebrafish by Metabolomic and Proteomic Analyses
Authors: Gong Lihong , Yu Linyuan , Gong Xiaohong , Wang Cheng , Hu Naihua , Dai Xuyang , Li Yunxia 
Published: December 2019

Abstract
Background: Inflammation is a general pathological phenomenon that operates during severe disturbance of homeostasis. Forsythiaside A (FA) and Forsythiaside B (FB) are isolated from air-dried fruits of Forsythia suspensa, which show a significant effect against inflammation. However, the anti-inflammatory effect and therapeutic mechanism have not yet been clarified in zebrafish. Methods: In this study, the anti-inflammatory effects of FA and FB were investigated in CuSO4-induced zebrafish model. Intracellular ROS and NO generation in zebrafish were performed using fluorescent probe dyes. Metabolomics and proteomics using liquid chromatography mass spectrometry were carried out to identify the expression of metabolites and proteins associated with chemically induced inflammation in zebrafish larvae. Quantitative PCR was performed to detect the progressive changes in the genes.Results: FA and FB inhibited neutrophils migration to the damaged neuromasts and remarkably reduced CuSO4-induced ROS and NO generation in zebrafish. Metabolomics analyses indicated that the Nicotinate and nicotinamide metabolism, Amino sugar and nucleotide sugar metabolism, Pyrimidine metabolism and Purine metabolism were mainly involved. The proteomic analyses identified 146 differentially expressed proteins, among which, the expression of collagen (col2a1b, col9a2, col9a1b), nme3, wdr3, mrps7, srpx, gch2, ptpn11a, rcvrn2, nit2, scaf4a and zgc:162509 were all reversed both in FA and FB groups. FA and FB could reverse the abnormal expression of these metabolites and proteins to alleviate chemical damage to the neuromasts in the lateral line of zebrafish.Conclusions: FA and FB possess remarkable anti-inflammatory effect and could be used to protect chemically induced neuromasts damage in zebrafish larvae.
The sex-specific influence of body mass index on the association between serum lipids and cognitive function in Chinese elderly population: data from 2009-2015 CHNS
Authors: Li Jiang , Cao Yongtong , Xiao Cheng 
Published: December 2019

Abstract
Objectives: Previous studies reported that the association between lipid levels and cognitive function related with sex, age and specific cognitive domains, but the influence of body mass index (BMI) on this association is limited. This triggered our interest in exploring how serum lipids relate to cognitive function in different BMI levels. Methods: Data was collected from 2009 wave and 2015 wave of China Health and Nutrition Survey (2009-2015 CHNS). Multivariable linear regression analyses examined serum lipids level as predictors of gender-specific measure of cognitive function in different BMI levels, which were adjusted for age, nationality, BMI, SBP, DBP, smoking status, alcohol consumption and education level. Results: Cognitive function score have different concentration curves in serum lipids quartile levels in different BMI categories. After adjustment for confounding factors, serum TG was positively associated with cognitive function score in underweight (β±SE: 2.06±0.88, P=0.023) and obese (β±SE: 1.44±0.71, P=0.045) male group, and serum HDL-C was positively associated with cognitive function score in overweight (β±SE: 1.89±0.92, P=0.041) and obese female group (β±SE: 5.04±1.62, P=0.002). Conclusions: The associations of serum lipids with cognitive function differed between different gender groups and were specific to BMI levels. This result indicated that better nutritional status has superior cognitive function performance.
Window phase analysis of nutrient losses from a typical rice-planting area in the Yangtze river delta region of China
Authors: He Shuang , Li Fayong , Liang Xinqiang , Li Hua , Wang Sheng , Jin Yingbing , Liu Boyi , Tian Guangming 
Published: December 2019

Abstract
Background Rice paddy wetlands may serve as a nutrient source or sink in agricultural ecosystems. However, the pattern of nutrient loss on a large scale is not clear. A year-round on-site observation study based on 6 h intervals was conducted. Rainfall, temperature, runoff nutrient concentrations, and adjacent stream water samples were automatically monitored to uncover the temporal changes in the runoff losses of the main nutrient proxies (total N and total P) from a typical rice-planting area (120 ha) in the Yangtze river delta region of China.Results A high total N concentration in the rice-planting area was observed during the rice-planting season; however, a larger fluctuation in the total P was evident throughout the year. The Δtotal N (drainage minus stream) parameter showed negative values with a mean of −0.25 mg L −1 , while Δtotal P showed positive values with a mean of 0.06 mg L −1 . The window phases for the total N loss are mainly concentrated in the rice-growing season. However, the window phase for the total P loss was more dispersive throughout the year. No clear relationships were found between rainfall and N and P concentrations by self-organizing map analysis.Conclusions This high-resolution monitoring suggested that nutrient loss loading, rather than nutrient concentration, was strongly related to runoff depth, and the avoidance of fertilization before high-intensity rainfall could mitigate the nutrient runoff losses and maintain the rice wetland eco-function.
AN ENERGY EFFICIENT SPECTRUM AWARE ROUTING FOR COGNITIVE RADIO NETWORKS
Authors: Bolla Dileep Reddy , Shivashankar  
Published: December 2019

Background:
Now a days Due to rapid increase in the internet the Spectrum available is been overcrowded and thus the spectrum Sensing can be achieved by using the predominant technology i.e., Cognitive Radio as the spectrum is been under-utilized by the wireless communication technologies.

Objective:
The prime objective of the research work carried out is to achieve the energy efficiency and to use the spectrum effectively by using the spectrum management concept and achieve better throughput, end to end delay etc.,

Methods:
The detection of the spectrum hole plays a vital role in the routing of the cognitive radio networks. As the hidden node problems and the multipath fading and the shadowing are considered to be impacting the sensing of the spectrum to overcome these issues Cooperative spectrum Sensing Mechanism is been adopted to sense the spectrum in an optimal manner and over cum the issues. Along with these issues the spectrum resources changes time to time in the routing.

Result:
An Energy Efficient Spectrum aware Routing (ESR) is been proposed which involves the timeslot and the routing schemes were been discussed. The simulation parameters have been proposed and the improvement in the performance of network
through and a decrease in the end-to end delay have been observed and analyzed.

Conclusion:
An Energy Efficient spectrum management and the routing is successfully established to communication in the network and further traffic load is observed to be balanced in the protocol based on the residual energy in a node and further it prologs the Network Lifetime of the Overall Network and the Individual CR user. Further the end-to-end Delay has been observed to be lower which ensure higher throughput in the network and improves the network life time.
Time-Synchronization Free Localization Scheme with Mobility Prediction for UAWSNs
Authors: Toky Archana , Singh Rishi P. , Das Sanjoy 
Published: December 2019

Background:
Underwater Acoustic Wireless Sensor Network supports a lot of civil and
military applications. It has come out as an effective tool to explore the ocean area of the earth.
Sensor deployed underwater can help to relate the events occurring underwater with the rest of the
world. To achieve the goal, the information gained from the sensors needs to be tagged with their
real-time locations.

Objective:
To study the effect of the mobility of the sensor nodes on the accuracy of the location
estimation during the localization period and develop a localization scheme which can give an accurate
result by predicting the mobility behavior of the sensors.

Methods:
In this paper, a time-synchronization free localization scheme for underwater networks
has been presented. The scheme employs a mobile beacon in the network to move vertically and
broadcast the beacon messages.

Results:
The performance evaluation shows that the scheme reduces the error in location estimation
caused by the mobility of the sensors by predicting their further location according to the mobility
pattern of the sensor node. In an existing localization scheme, nodes are localized without
time-synchronization but the scheme does not consider the mobility of the senor between the reception
of two messages. The result of shows that the proposed localization scheme has achieved
success in reducing the localization error by introducing the mobility behavior of the sensors in
the existing localization scheme.

Conclusion:
localization scheme without a need of time-synchronization is presented. The main
reason of the inaccuracy of a localization scheme is the mobility of the sensor node during the
range estimation. The accuracy of a localization scheme can be improved by prediction the mobility
pattern of the sensor during a localization period.