bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development, Amplification, and Decay of Atlantic/European Summer Weather Patterns Linked to Spring North Atlantic Sea Surface Temperatures
Authors: Ossó Albert , Sutton Rowan , Shaffrey Len , Dong Buwen 
Published: May 2020

AbstractA recent study identified a relationship between North Atlantic Ocean sea surface temperature (SST) gradients in spring and a specific pattern of atmospheric circulation in the following summer: the summer east Atlantic (SEA) pattern. It was shown that the SEA pattern is closely associated with meridional shifts in the eddy-driven jet in response to anomalous SST gradients. In this study, the physical mechanisms underlying this relationship are investigated further. It is shown that the predictable SEA pattern anomalies appear in June–July and undergo substantial amplification between July and August before decaying in September. The associated SST anomalies also grow in magnitude and spatial extent from June to August. The question of why the predictable atmospheric anomalies should occur in summer is addressed, and three factors are identified. The first is the climatological position of the storm track, which migrates poleward from spring to summer. The second is that the magnitude of interannual SST variability underlying the storm track peaks in summer, both in absolute terms, and relative to the underlying mean SST gradient. The third factor is the most interesting. We identify a positive coupled ocean–atmosphere feedback, which operates in summer and leads to the amplification of both SST and atmospheric circulation anomalies. The extent to which the identified processes are captured in the HadGEM3-GC2 climate model is also assessed. The model is able to capture the relationship between spring North Atlantic SSTs and subsequent ocean–atmosphere conditions in early summer, but the relationship is too weak. The results suggest that the real world might be more predictable than is inferred from the models.
Using A-Train Observations to Evaluate East Pacific Cloud Occurrence and Radiative Effects in the Community Atmosphere Model
Authors: Berry Elizabeth , Mace Gerald G. , Gettelman Andrew 
Published: May 2020

AbstractUsing information from the A-Train satellites, the properties and radiative effects of eastern Pacific Ocean boundary layer clouds are evaluated in the Community Atmosphere Model, version 5 (CAM5), from the summer of 2007 and 2008. The cloud microphysical properties are inferred using measurements from CloudSat and CALIPSO (CC) that are then used to calculate the broadband radiative flux profiles. Accounting appropriately for sampling differences between the measurements and the simulation, evidence of the “too few, too bright” low cloud bias is found in CAM5. Single-layer low clouds have a frequency of occurrence of 42% from CC, as compared with just 29% in CAM5, and the averaged cloud radiative kernel (CRK) for the model shows stronger cooling. For stratocumulus in particular, the cooling in the model CRK is larger by a factor of 2 relative to the observations, implying an overly sensitive tropical low cloud feedback. Differences in the day/night occurrence of stratocumulus help to explain some of the difference in the CRK. The cloud-type microphysics for liquid clouds is represented reasonably well by the model, with a tendency for smaller water paths and smaller effective radii. Overall, the occurrence and CRK have partially compensating errors such that the net cooling at the top of the atmosphere for eastern Pacific low clouds is −43 W m−2 in CAM5, as compared with −32 W m−2 from CC. The cooling effect in the model is accomplished by fewer low clouds with a narrower range of properties, as compared with more clouds with a broader range of properties in the observation-based dataset.
Improving Near-Surface Short-Range Weather Forecasts Using Strongly Coupled Land–Atmosphere Data Assimilation with GSI-EnKF
Authors: Lin Liao-Fan , Pu Zhaoxia 
Published: May 2020

AbstractStrongly coupled land–atmosphere data assimilation has not yet been implemented into operational numerical weather prediction (NWP) systems. Up to now, upper-air measurements have been assimilated mainly in atmospheric analyses, while land and near-surface data have been assimilated mainly into land surface models. Thus, this study aims to explore the benefits of assimilating atmospheric and land surface observations within the framework of strongly coupled data assimilation. Specifically, we added soil moisture as a control state within the ensemble Kalman filter (EnKF)-based Gridpoint Statistical Interpolation (GSI) and conducted a series of numerical experiments through the assimilation of 2-m temperature/humidity and in situ surface soil moisture data along with conventional atmospheric measurements such as radiosondes into the Weather Research and Forecasting (WRF) Model with the Noah land surface model. The verification against in situ measurements and analyses show that compared to the assimilation of conventional data, adding soil moisture as a control state and assimilating 2-m humidity can bring additional benefits to analyses and forecasts. The impact of assimilating 2-m temperature (surface soil moisture) data is positive mainly on the temperature (soil moisture) analyses but on average marginal for other variables. On average, below 750 hPa, verification against the NCEP analysis indicates that the respective RMSE reduction in the forecasts of temperature and humidity is 5% and 2% for assimilating conventional data; 10% and 5% for including soil moisture as a control state; and 16% and 11% for simultaneously adding soil moisture as a control state and assimilating 2-m humidity data.
Effect of sitagliptin on expression of skeletal muscle peroxisome proliferator-activated receptor γ coactivator-1α and irisin in a rat model of type 2 diabetes mellitus
Authors: Liu Yuntao , Xu Feng , Jiang Pan 
Published: May 2020

Objective To evaluate the effect of sitagliptin on skeletal muscle expression of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), irisin, and phosphoadenylated adenylate activated protein kinase (p-AMPK) in a rat model of type 2 diabetes mellitus (T2DM). Methods A high-fat diet/streptozotocin T2DM rat model was established. Rats were divided into T2DM, low-dose sitagliptin (ST1), high-dose sitagliptin (ST2), and normal control groups (NC). PGC-1α, irisin, and p-AMPK protein levels in skeletal muscle were measured by western blot, and PCG-1α and Fndc5 mRNA levels were assessed by reverse transcription-polymerase chain reaction. Results Fasting plasma glucose (FPG), fasting insulin (FIns), homeostatic model assessment-insulin resistance (HOMA-IR), and tumor necrosis factor-α (TNF-α) were significantly up-regulated in the T2DM compared with the other groups, and FPG, FIns, total cholesterol, triglycerides, TNF-α, and HOMA-IR were significantly down-regulated in the ST2 compared with the ST1 group. PGC-1α, irisin, and p-AMPK expression levels decreased successively in the ST2, ST1, and DM groups compared with the NC, and were all significantly up-regulated in the ST2 compared with the ST1 group. Conclusion Down-regulation of PGC-1α and irisin in skeletal muscle may be involved in T2DM. Sitagliptin can dose-dependently up-regulate PCG-1α and irisin, potentially improving insulin resistance and glycolipid metabolism and inhibiting inflammation.
The efficacy and tolerability of febuxostat treatment in a cohort of Chinese Han population with history of gout
Authors: Huang Yuan-Yuan , Ye Zhuang , Gu San-Wei , Jiang Zhen-Yu , Zhao Ling 
Published: May 2020

Objective To measure the effect of febuxostat on the serum levels of uric acid (sUA) and the proinflammatory cytokines interleukin (IL)-6, IL-17 and tumour necrosis factor-α (TNF-α) in Chinese Han patients with gout and hyperuricaemia. Methods This randomized, double-blind, placebo-controlled pilot study enrolled patients with gout and hyperuricaemia (sUA ≥ 8 mg/dl). Patients were randomized to receive either febuxostat 80 mg or placebo once daily for 24 weeks. The serum levels of sUA, IL-6, IL-17 and TNF-α were measured at weeks 0 (baseline), 2, 4, 8, 12, 16 and 24. Baseline clinical and demographic characteristics were recorded for all patients. Results A total of 156 patients were randomized: placebo group ( n = 78) and febuxostat group ( n = 78). The febuxostat group showed a significantly greater reduction in sUA compared with the placebo group. Serum uric acid concentration was reduced below 8 mg/dl in 46 of 61 patients (75.4%) by week 24. There were also reductions in the serum levels IL-6, IL-17 and TNF-α in the febuxostat group. In the febuxostat group, 10 of 78 patients (12.82%) discontinued treatment due to adverse drug reactions. Conclusion Febuxostat reduced the levels of sUA, TNF-α, IL-6 and IL-17, but there were some side-effects.
Electroacupuncture improves synaptic plasticity by regulating the 5-HT1A receptor in hippocampus of rats with chronic unpredictable mild stress
Authors: Chen Lixing , Yao Zengyu , Qu Shanshan , Zhang Jialing , Zhang Jiping , Zhang Zhinan , Huang Yong , Zhong Zheng 
Published: May 2020

Objectives To investigate the antidepressant effects of electroacupuncture (EA) on chronic unpredictable mild stress (CUMS) in rats, as well as the effects of EA on hippocampal neurons, synaptic morphology, and 5-hydroxytryptamine (HT) receptor expression. Methods Forty adult male Wistar rats were randomly divided into normal control, CUMS, EA, and paroxetine groups. CUMS modeling was performed for 21 days, followed by 14 days of intervention: rats in the EA group underwent stimulation of GV20 and GV29 acupuncture points for 30 minutes daily; rats in the paroxetine group were administered paroxetine daily. Behavioral tests, transmission electron microscopy, western blotting, and real-time quantitative polymerase chain reaction were used to evaluate the effects of the intervention. Results EA treatment reversed the behavioral changes observed in rats due to CUMS modeling; it also improved the pathological changes in organelles and synaptic structures of hippocampal neurons, and upregulated the protein and mRNA expression levels of 5-HT1A receptor. There were no significant differences in 5-HT1B receptor protein and mRNA expression levels among the groups. Conclusions EA treatment can alleviate depression-like symptoms in CUMS rats. The underlying mechanism may include promoting the expression of 5-HT1A receptor mRNA and protein, thereby improving synaptic plasticity in the hippocampus.
Pre-infusion single-dose mesenchymal stem cells promote platelet engraftment and decrease severe acute graft versus host disease without relapse in haploidentical peripheral blood stem cell transplantation
Authors: Wang Xiaoning , Zhang Mei , He Pengcheng 
Published: May 2020

Background Mesenchymal stem cells (MSCs) may be used to treat steroid-refractory graft versus host disease (GVHD). However, the effects of MSCs in haploidentical peripheral blood stem cell transplantation (haplo-PBSCT) have not been confirmed in randomized studies. Methods We conducted a randomized clinical study to investigate the effects of pre-infusion (1 × 106 cells/kg) MSCs on hematopoietic recovery, Epstein–Barr and cytomegalovirus infection, GVHD, and relapse in patients undergoing haplo-PBSCT. Fifty patients with acute leukemia or myelodysplastic syndrome were randomly divided into an MSC group administered 1 × 106 MSCs/kg 4 to 6 hours before infusion of peripheral stem cells and a control group without MSCs. Results Mean platelet engraftment time was significantly faster in the MSC compared with the control group (12.28 vs 13.29 days). The mean neutrophil engraftment time was comparable in both groups (10.76 ± 2.40 vs. 10.29 ± 1.72 days). Grade II or above acute GVHD was significantly decreased in the MSC compared with the control group (12% vs. 36%). There were no significant differences in relapse rate or overall survival between the groups. Conclusion These results suggest that pre-infusion single-dose MSCs promote platelet engraftment and decrease severe acute GVHD without increasing relapse rate.
Use of a natural multicomponent mouthwash plus oral hygiene vs oral hygiene alone to prevent everolimus-induced stomatitis: the STOP multicenter, randomized trial
Authors: Porta Camillo , Verzoni Elena , Zai Silvia , Messina Caterina , Ferrari Vittorio , Gri Nicole , Procopio Giuseppe 
Published: May 2020

Background: Stomatitis is highly prevalent in patients with cancer treated with the mammalian target of rapamycin inhibitor everolimus; it usually has an early onset and may compromise treatment dose intensity and patients’ quality of life. Within the randomized controlled Stomatitis Prevention trial (STOP, ISRCTN14568888), we investigated the possibility of using a commercial natural multicomponent mouthwash (Orasol Plus®) to prevent the development of stomatitis of any grade in patients with advanced renal cell carcinoma (RCC) treated with everolimus. Methods: Overall, 62 patients were randomized to receive either Orasol Plus in addition to oral hygiene or oral hygiene alone (31 patients per treatment arm). Results: In the whole study population, 28 episodes of stomatitis were observed (41.9%); in only 2 patients, stomatitis occurred more than once (2 episodes). As expected, the episodes of stomatitis occurred early in the course of treatment with everolimus. Treatment with Orasol Plus prevented the onset of everolimus-induced stomatitis: only 8 episodes of stomatitis were observed in the treated group with Orasol Plus in addition to oral hygiene vs 20 episodes in the group treated with oral hygiene only ( p = 0021). Also, a reduction in the average duration of mucositis in patients treated with Orasol Plus compared to patients treated with oral hygiene only was observed (8 days vs 11.2 days, p = 0.0416). Conclusion: This study showed that the use of a natural multicomponent mouthwash coupled with regular oral hygiene was able to reduce the severity and duration of everolimus-induced stomatitis in patients with RCC. Trial registration number: ISRCTN14568888
The Intersection between Criminal Accusations, Victimization, and Mental Disorders: A Canadian Population-Based Study
Authors: Casiano Hygiea , Hensel Jennifer M. , Chartier Mariette J. , Ekuma Okechukwu , MacWilliam Leonard , Mota Natalie , McDougall Chelsey , Bolton James M. 
Published: May 2020

Objective: Understand the relationship between criminal accusations, victimization, and mental disorders at a population level using administrative data from Manitoba, Canada. Method: Residents aged 18 to 64 between April 1, 2007, and March 31, 2012 ( N = 793,024) with hospital- and physician-diagnosed mental disorders were compared to those without. Overall and per-person rates of criminal accusations and reported victimization in the 2011/2012 fiscal year were examined. Relative risks were calculated, adjusting for age, sex, income, and presence of a substance use disorder. The overlap between diagnosed mental disorders, accusations, and victimization with a χ2 test of independence was studied. Results: Twenty-four percent ( n = 188,693) of the population had a mental disorder over the 5-year time frame. Four to fifteen percent of those with a mental disorder had a criminal accusation, compared to 2.4% of the referent group. Individuals with mental disorders, especially psychotic or personality disorders, were often living in low-income, urban neighborhoods. The adjusted relative risk of accusations and victimization remained 2 to 5 times higher in those with mental disorders compared to the referent group. Criminal accusations and victimization were most prevalent among individuals with a history of attempted suicide (15.2% had an accusation and 8.1% were victims). The risk of victimization in the same year as a criminal accusation was significantly increased among those with mental disorders compared to those without (χ2 = 211.8, P < 0.001). Conclusions: Individuals with mental disorders are at elevated risk of both criminal involvement and victimization. The identification of these multiply-stigmatized individuals may lead to better intervention and support.
Alcohol Use Disorder and the Persistence/Recurrence of Major Depression: Le trouble de l’usage de l’alcool et la persistance/récurrence de la dépression majeure
Authors: Onaemo Vivian N. , Fawehinmi Timothy O. , D’Arcy Carl 
Published: May 2020

Objective This study aims to determine the role of alcohol use disorder and other potential risk factors on persistence/recurrence of major depression in a Canadian population sample. Methods Data were drawn from the National Population Health Survey (1994/1995 to 2010/2011), a prospective epidemiologic survey of individuals 12 years and older, living in 10 Canadian provinces ( N = 17,276). Participants were reinterviewed every 2 years for 9 cycles. This study population was a cohort of individuals who at baseline met the diagnosis of a major depressive episode (MDE) in the previous 12 months ( n = 908). After the 6-year (cycle 4) and 16-year (cycle 9) follow-up period, 124 of 718 participants and 79 of 461 participants met the criteria for MDE, respectively. Persistence or recurrence of major depression was defined as meeting a diagnosis of MDE after 6 years and 16 years. Modified Poisson regression models were used to assess the role of alcohol dependence and other risk factors on the persistence/recurrence of major depression using Stata 14. Results Alcohol use disorder was significantly correlated with a 6-year (odds ratio [ OR]: 3.03; 95% confidence interval [CI], 1.68 to 5.48; P < .0001) and 16-year ( OR, 3.17; 95% CI, 1.15 to 8.77, P = 0.003) persistence/recurrence of major depression. Other factors associated with the persistence/recurrence of major depression include female sex, childhood traumatic events, chronic pain restricting activities, daily smoking, and low self-esteem. Conclusions Comorbid alcohol use disorder was found to be a strong risk factor for the persistence or recurrence of major depression.
Multiplatform, Non-Breath-Hold Fast Scanning Protocols: Should We Stop Giving Breath-Hold Instructions for Routine Chest CT?
Authors: Doda Khera Ruhani , Nitiwarangkul Chayanin , Singh Ramandeep , Homayounieh Fatemeh , Digumarthy Subba R. , Kalra Mannudeep K. 
Published: May 2020

Objective: We assessed if non-breath-hold (NBH) fast scanning protocol can provide respiratory motion-free images for interpretation of chest computed tomography (CT). Materials and Methods: In our 2-phase project, we first collected baseline data on frequency of respiratory motion artifacts on breath-hold chest CT in 826 adult patients. The second phase included 62 patients (mean age 66 ± 15 years; 21 females, 41 males) who underwent an NBH chest CT on either single-source (n = 32) or dual-source (n = 30) multidetector-row CT scanners. Clinical indications for chest CT, reason for using NBH CT, scanner type, scan duration, and radiation dose (CT dose index volume, dose length product) were recorded. Two thoracic radiologists (R1 and R2) independently graded respiratory motion artifacts (1 = no respiratory motion artifacts with unrestricted evaluation; 2 = minor motion artifacts limited to one lung lobe or less with good diagnostic quality; 3 = moderate motion artifacts limited to 2 to 3 lung lobes but adequate for clinical diagnosis; 4 = poor evaluability or unevaluable from severe motion artifacts; and 5 = limited quality due to other causes like high noise, beam hardening, or metallic artifacts), and recorded pulmonary and mediastinal findings. Descriptive analyses, Cohen κ test for interobserver agreement, and Student t test were performed for statistical analysis. Results: No NBH chest CT were deemed uninterpretable by either radiologist; most NBH CT (R1-59 of 62, 95%; R2-62 of 62, 100%) had no or minimal motion artifacts. Only 3 of 62 (R1) NBH chest CT had motion artifacts limiting diagnostic evaluation for lungs but not in the mediastinum. Conclusion: Non-breath-hold fast protocol enables acquisition of diagnostic quality chest CT free of respiratory motion artifacts in patients who cannot hold their breath.
Differences in Consumption of NASEM Priority Nutrients and Food Groups by Race/Ethnicity Among Women Living in WIC-Participating Households
Authors: Zimmer Meghan C. , Rubio Veronica , Kintziger Kristina W. , Barroso Cristina 
Published: May 2020

Purpose: To examine racial/ethnic differences in dietary intake of women in the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC). Design: Cross-sectional study. Setting: Data from the US National Health and Nutrition Examination Survey. Participants: Women 19 to 50 years of age living in WIC-participating households. Measures: Nutrient/food group intake from one 24-hour dietary recall. Analysis: Multivariable linear regression was used to evaluate the relationship between race/ethnicity and nutrient/food group intake. Results: Compared to non-Hispanic white women, Hispanic women had lower dietary energy density (1.7 ± 0.1 vs 2.2 ± 0.1 kcal/g, P < .001), and better nutrient intake, including more folate (429 ± 20 vs 364 ± 29 µg, P = .024), fiber (20.1 ± 0.9 vs 13.6 ± 0.9 g, P ≤ .001), and potassium (2575 ± 78 vs 2251 ± 66 mg, P = .012). This may be related to greater consumption of total vegetables (1.67 ± 0.16 vs 1.17 ± 0.17 cup equivalents [c-eq], P = .029), including more red and orange vegetables (0.64 ± 0.11 vs 0.32 vs 0.09 c-eq, P = .013) and more legumes (0.17 ± 0.04 vs 0.07 ± 0.02 c-eq, P = .006). Both Hispanic and non-Hispanic black women consumed more sodium (Hispanic: P = .015; non-Hispanic black: P = .008), but less added sugars (Hispanic: P ≤ .001; non-Hispanic black: P = .015), than non-Hispanic white women. Conclusion: These findings highlight differences in dietary intake by race/ethnicity and can inform nutrition messages of WIC nutrition educators and dietitians.