bluuebunny/crossref_metadata_2025_split huggingface dataset:
The genealogy of traditional Javanese cassava-based foods
Authors: Herminingrum Sri 
Published: November 2019

AbstractCassava is generally consumed by Javanese who inhabited the areas where cassava plant is cultivated; therefore, culturally, it has ethnic importance. Even though formerly it was regarded as marginal food, its existence follows the nature of culture—ever-changing based on space and time. The study done aims to disclose the genealogy of various kinds of cassava-based foods in connection with Javanese food choices and food ways. Accordingly, the discussion encompasses the materials used, the preparation methods; cooking, serving, and giving suitable complements; the specific functions, the origin, and its development from the past to the present day. The findings significantly demonstrate that the numerous foods generated from cassava roots and leaves, covering staple foods, light meals, side dishes, and drinks, are manifestation of Indonesian cultural diversity. More importantly, this ethnic food in general is also inherent with the Javanese philosophy on living in harmony between humans and the nature surrounding that should be well managed. These two points underline that cassava-based food identity is not a mere cultural expression. It is built by Javanese communities through their natural experiences, simple knowledge, and hard efforts to make cassava-based foods still exist in agreement with the developing era.
MUNC18-1 regulates the submembrane F-actin network, independently of syntaxin1 targeting, via hydrophobicity in β-sheet 10
Authors: Pons-Vizcarra Maria , Kurps Julia , Tawfik Bassam , Sørensen Jakob B. , van Weering Jan R. T. , Verhage Matthijs 
Published: November 2019

ABSTRACT
MUNC18-1 (also known as STXBP1) is an essential protein for docking and fusion of secretory vesicles. Mouse chromaffin cells (MCCs) lacking MUNC18-1 show impaired secretory vesicle docking, but also mistargeting of SNARE protein syntaxin1 and an abnormally dense submembrane F-actin network. Here, we tested the contribution of both these phenomena to docking and secretion defects in MUNC18-1-deficient MCCs. We show that an abnormal F-actin network and syntaxin1 targeting defects are not observed in Snap25- or Syt1-knockout (KO) MCCs, which are also secretion deficient. We identified a MUNC18-1 mutant (V263T in β-sheet 10) that fully restores syntaxin1 targeting but not F-actin abnormalities in Munc18-1-KO cells. MUNC18-2 and -3 (also known as STXBP2 and STXBP3, respectively), which lack the hydrophobic residue at position 263, also did not restore a normal F-actin network in Munc18-1-KO cells. However, these proteins did restore the normal F-actin network when a hydrophobic residue was introduced at the corresponding position. Munc18-1-KO MCCs expressing MUNC18-1(V263T) showed normal vesicle docking and exocytosis. These results demonstrate that MUNC18-1 regulates the F-actin network independently of syntaxin1 targeting via hydrophobicity in β-sheet 10. The abnormally dense F-actin network in Munc18-1-deficient cells is not a rate-limiting barrier in secretory vesicle docking or fusion.
This article has an associated First Person interview with the first author of the paper.
Intervening along the spectrum of tuberculosis: meeting report from the World TB Day nanosymposium in the Institute of Infectious Disease and Molecular Medicine at the University of Cape Town
Authors: Hadebe Sabelo , Chengalroyen Melissa , Guler Reto , Nakedi Kehilwe , Koch Anastasia , Makatsa Mohau , Shey Muki , Parihar Suraj P. , Bryson Bryan , Marakalala Mohlopheni J. , Ndlovu Hlumani 
Published: November 2019

Tuberculosis (TB), caused by the highly infectious Mycobacterium tuberculosis, remains a leading cause of death worldwide, with an estimated 1.6 million associated deaths reported in 2017. In South Africa, an estimated 322,000 (range 230,000-428,000) people were infected with TB in 2017, and a quarter of them lost their lives due to the disease. Bacille Calmette-Guérin (BCG) remains the only effective vaccine against disseminated TB, but its inability to confer complete protection against pulmonary TB in adolescents and adults calls for an urgent need to develop new and better vaccines. There is also a need to identify markers of disease protection and develop novel drugs. It is within this backdrop that we convened a nanosymposium at the Institute of Infectious Disease and Molecular Medicine at the University of Cape Town to commemorate World TB Day and showcase recent findings generated by early career scientists in the institute. The speakers spoke on four broad topics: identification of novel drug targets, development of host-directed drug therapies, transmission of TB and immunology of TB/HIV co-infections.
Variation in the observed effect of Xpert MTB/RIF testing for tuberculosis on mortality: A systematic review and analysis of trial design considerations
Authors: Ochodo Eleanor A. , Kalema Nelson , Schumacher Samuel , Steingart Karen , Young Taryn , Mallett Susan , Deeks Jon , Cobelens Frank , Bossuyt Patrick M. , Nicol Mark P. , Cattamanchi Adithya 
Published: November 2019

Background: Most studies evaluating the effect of Xpert MTB/RIF testing for tuberculosis (TB) concluded that it did not reduce overall mortality compared to usual care. We conducted a systematic review to assess whether key study design and execution features contributed to earlier identification of patients with TB and decreased pre-treatment loss to follow-up, thereby reducing the potential impact of Xpert MTB/RIF testing. Methods: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, and Scopus for literature published from 1st January 2009 to February 2019. We included all primary intervention studies that had evaluated the effect of Xpert MTB/RIF on mortality compared to usual care in participants with presumptive pulmonary TB. We critically reviewed features of included studies across: Study setting and context, Study population, Participant recruitment and enrolment, Study procedures, and Study follow-up. Results: We included seven randomised and one non-randomised study. All included studies demonstrated relative reductions in overall mortality in the Xpert MTB/RIF arm ranging from 6% to 40%. However, mortality reduction was reported to be statistically significant in two studies. Study features that could explain the lack of observed effect on mortality included: the higher quality of care at study sites; inclusion of patients with a higher pre-test probability of TB leading to higher than expected empirical rates; performance of additional diagnostic testing not done in usual care leading to increased TB diagnosis or empiric treatment initiation; the recruitment of participants likely to return for follow-up; and involvement of study staff in ensuring adherence with care and follow-up. Conclusion: Most studies of Xpert MTB/RIF were designed and conducted in a manner that resulted in more patients being diagnosed and treated for TB, minimising the potential difference in mortality Xpert MTB/RIF testing could have achieved compared to usual care.
Role of a regulatory and governance framework in human biological materials and data sharing in National Biobanks: Case studies from Biobank Integrating Platform, Taiwan and the National Biorepository, Uganda
Authors: Nansumba Hellen , Ssewanyana Isaac , Tai Micheal , Wassenaar Douglas 
Published: November 2019

Background: In the last decade, Low- and Middle-Income Countries (LMICs) have set up Biobanks to collect human biological materials and associated data for genomic research and public health purposes. Biobanking gives rise to ethical challenges, such as informed consent, benefit sharing, confidentiality, ownership, commercialization and public participation which are harder to navigate in LMIC settings due to disparities in research infrastructure and capacity. This paper summarizes presentations on Biobank related case studies from two countries, with a focus on challenges in the regulatory and governance framework and suggestions on how to mitigate them. Methods: Two case studies of Biobanks from LMICs have been used. The case studies were presented at the 2018 Global Forum on Bioethics in Research (GFBR) meeting on the “Ethics of data sharing and Biobanking in health research”. Results: The case studies show that an integrated, well-regulated platform for human biological materials and data ensures good quality of human biological materials, saves resources and promotes mutual collaboration of work among researchers. National regulatory bodies are required to generate Biobanking guidelines and policies to facilitate guidance to the rapidly changing landscape of science. Discussion: In general, LMICs have weaker research regulatory infrastructure and governance mechanisms for Biobanks than high-income countries. This has increased the fear of exploitation i.e. unfair distribution of risks and benefits. Establishment of Biobanks and producing effective scientific outcomes based on the Biobanking resources is difficult without a proper legislative, regulatory and governance framework. Conclusion: These two case studies from different LMICs settings show that although in both settings there is strong awareness of the scientific and population health value of Biobanks and strong commitment to their establishment, regulatory and ethical guidance show gaps that need to be addressed.
Educational role of the nurse in relation to sexual behavior of junior high school students
Authors: Brodowicz-Król Magdalena 
Published: November 2019

Human sexuality and sexuality in modern times are widely discussed topics. There are many publications that deal with this issue. This is perhaps due to the following global. socio-cultural changes, the return of which is unknown in the long run. The transformations concern the perception of a sense of gender identity. Scholars wanting to capture this extremely rich reality in a certain framework using a variety of tools. They do this rarely bypassing contexts, in line with prevailing trends, which prevents them from looking objectively at the subject of their research. Such research germinates with information chaos that floods us all pages.Aim : The purpose of the work is the educational role of the nurse in youth attitudes towards sexual behavior.Material and Methods :The research was carried out at the turn of April and June 2014. The study involved 94 students from two schools from the Junior High School in Wólka Pełkińska, Podkarpackie Province and from G Junior High School No. 9 in Lublin, Lubelskie Province. The diagnostic method that was used in the study was the diagnostic survey. The research tool used was the scale "Attitudes of junior high school students towards sexual behavior". It consists of 21 questions, of which eight are questions from the record. The database was created and statistical analyzes were carried out based on Statistica 9.1 computer software ( StatSoft , Poland).Rezults : The relationships that were shown in the description of the research of this work could result in pedagogical practice. Knowing what relationships prevail in the chosen topic, one could take specific pedagogical actions. Such activities would be, for example, the orientation of school curricula of knowledge subjects to family life, and more specifically topics in the field of premarital chastity as well as sex education. However, this process could not be left without control or specifically planned actions. Conclusion : Selected research tools have proved to meet the needs of the research problem posed. Thanks to the interpretation of the results obtained thanks to them, it turned out that there was a relationship that was sought in the research. It says that the attitudes of junior high school students towards sexual behavior are directly related to social conditions. The hypotheses put forward at work proved successful - the gender structure differentiates attitudes of junior high school students towards sexual behavior.
Sustaining the commitment to patient safety huddles: insights from eight acute hospital ward teams
Authors: Montague Jane , Crosswaite Kate , Lamming Laura , Cracknell Alison , Lovatt Alison , Mohammed Mohammed A 
Published: November 2019

Background: A recent initiative in hospital settings is the patient safety huddle (PSH): a brief multidisciplinary meeting held to highlight patient safety issues and actions to mitigate identified risks. Aim: The authors studied eight ward teams that had sustained PSHs for over 2 years in order to identify key contributory factors. Methods: Unannounced observations of the PSH on eight acute wards in one UK hospital were undertaken. Interviews and focus groups were also conducted. These were recorded and transcribed for framework analysis. Findings: A range of factors contributes to the sustainability of the PSH including a high degree of belief and consensus in purpose, adaptability, determination, multidisciplinary team involvement, a non-judgemental space, committed leadership and consistent reward and celebration. Conclusion: The huddles studied have developed and been shaped over time through a process of trial and error, and persistence. Overall this study offers insights into the factors that contribute to this sustainability.
Musicals and the envoicing of mental illness and madness: From Lady in the Dark to Man of La Mancha (and beyond)
Authors: Knapp Raymond , Knapp Zelda 
Published: November 2019

Abstract
Because musicals routinely position musical expression as an enabling form of madness, they can have a difficult time when they try to consider mental illness in thoughtful ways. This essay considers four prominent musicals that deal overtly with mental illness and/or madness to delineate these difficulties and show how musicals try to surmount them. The relatively few musical numbers in Lady in the Dark (1941) allow its protagonist Liza Elliott to both confront her mental block and give voice to her emancipation. In Anyone Can Whistle (1964), Hapgood's ambiguous mental status allows him to swing from absurdities to rebellion to the touchingly human, each phase differently opposing the insanities of the world. Quixote, in Man of La Mancha (1965), defies reality in favour of impossible dreams. And the songs of next to normal (2008) provide a panoply of escapes from the painful realities of the dysfunctional Goodman family, none of whom quite finds a way to a desired 'normal'. As these shows exemplify, mentally unstable women and men generally have different options in musicals: women (at least, Liza and Diana Goodman) are obliged to chart paths to mental wholeness, with decidedly mixed results, whereas men (at least, Hapgood and Quixote) are allowed to indulge their flights from reality as forms of romanticized idealism, becoming heroes and liberators in the process. Next to normal exemplifies a renewed determination to take mental illness seriously in musicals, further advanced in the four-season television series Crazy Ex-Girlfriend.
The moaning of (un-)life: Animacy, muteness and eugenics in cinematic and televisual representation
Authors: Deaville James 
Published: November 2019

Abstract
This article analyses the eugenicist imperative governing speaking and non-speaking characters in western televisual representations, including films such as The Bride of Frankenstein (1935) and The Shape of Water (2017), and in the trope of the zombie. Typically, sublinguistic sounds are either assigned to human characters with supposed intellectual disabilities, or to reanimated, subhuman characters such as monsters and zombies. In both cases, characters denied speech are subject to isolation, sterilization or death, thus mirroring the status of voice in western constructions of humanness as it informs eugenicist discourse on disability.
Singing tone: Disability and pianistic voices
Authors: Honisch Stefan Sunandan 
Published: November 2019

Abstract
Humans experience multiple forms of vocality not only through encounters with each other but also with other animals (e.g. the crying wolf), and in moving through natural environments (e.g. the howling wind). Music likewise affords varied opportunities to experience and express ourselves as vocalizing beings, giving rise to complex relationships between speaking, singing and playing musical instruments. This piece considers the built-in percussiveness of the piano against the aesthetic prestige of lyricism – that is, 'songfulness' – as it encodes ableist choreographies on the part of the pianist. Disabled performers whose embodied relationships to their instrument transgress the corporeal biases of piano performance and pedagogy thus defy the aesthetic limits of normative lyricism: by foregrounding interstitial gesture, and multi-sensory expression, they envoice a new aesthetic that I call 'disabled songfulness'. Their pianistic voices, I argue, reach beyond stage and studio, refusing containment within the sensory hierarchies out of which music is often made.
"20.000 legoako bidaia itsaspetik" obraren 150. urteurrenean
Authors: Zaldibar Aranburu Beñat 
Published: November 2019

1869 eta 1870. urteen bitartean Jules Vernek bere obra nagusietako bat plazaratu zuen; «20.000 legoako bidaia itsaspetik» hain zuzen. Nobela hau Vernek seguruenik momentura arte sortu zuen nobelarik handiena da. Lan erraldoi horretan, Nautilus urpeko ontzi mitikoari esker itsasoetako sekretuak azaleratzen zaizkigu bidaia entretenigarri bezain hezitzaile batean, gaztetxoei (eta ez horren gaztetxoei) itsasoaren ikerketari buruzko sarbide paregabea eskainiz. Artikulu honetan, nobelaren eta haren autorearen inguruko zenbait gogoeta azaltzen dira; autoreak erakusten duen jakintza zientifiko eta koherentzia handia (baina inperfektua) eta Vernek geroago etorriko diren autoreengan duen eraginari buruzko hausnarketa txiki bat ere azaltzen da. Izan ere, ez dira egunero 150 urte betetzen, eta nobelaren garrantziak eta eraginak merezi du esfortzu txiki hau burutzea.
Медиатизация православия — это возможно?
Authors: Островская Елена Александровна 
Published: November 2019

Тотальная медиатизация всех сфер современных обществ ставит социологов перед непростой проблемой необходимости ревизии устоявшихся теорий и подходов. Применительно к отечественной и зарубежной социологии религии это означает ревизию все еще используемой по старинке парадигмы секуляризации. Институционально оформившееся медиаизмерение традиционных религий слабо укладывается в жесткие рамки теорий секуляризации, предписывающих трактовать любые инновации религиозной системы как ее обмирщение и выхолащивание. В такой системе координат плохо помещаются медиатизированные миры традиционных религий, опосредующие выходы религий в публичные социальные пространства. Так, совершенно незамеченным остался прецедент 2015 г., когда православный иеромонах Фотий стал победителем развлекательного шоу «Голос» и концертирующим «Голосом России». В равной степени вне социологической рефлексии пребывает и российское православие эпохи web 2.0 — множественные цифровые церковные СМИ, медиахолдинги, сайты Московского патриархата и синодальных отделов, приходов и православных храмов, православная поисковая система, священнические и монашеские профили в социальных сетях Vk.com, Facebook, Instagram, медийное вещание православных подкастов и спутниковых каналов, видеоблоги и документалистика на платформе YouTube. Меж тем, определенным образом соотнесенные офлайн- и онлайн-измерения современного российского православия конструируют новые идентичности, сообщества, модели национального патриотизма, процедуры цензуры и контроля российских медиа- и интернет-пространств. Настоящая статья предлагает проанализировать медиатизацию российского православия как составляющую процесса его долгосрочной реинституционализации. В качестве методологической рамки исследования автор использует концепции медиатизации общества, предложенные Фридрихом Кротцем, Андреасом Хеппом и Ником Коулдри. Это позволяет рассмотреть уже существующие православные медиамиры и кейс иеромонаха Фотия как маркеры определенных этапов реинституционализации российского православия.
Благодарность. Исследование выполнено при финансовой поддержке РФФИ, в рамках проекта № 19-011-00871 «Социальные медиа как фактор трансформации православия в современной России».
Evaluation of the primary biliary cholangitis-related serologic profile in a large cohort of Belgian systemic sclerosis patients
Authors: Florin Lisa , Rubben Kaat , Vanhaecke Amber , Devreese Katrien , De Keyser Filip , Smith Vanessa , Bonroy Carolien 
Published: November 2019

Abstract

Background
Systemic sclerosis (SSc) and primary biliary cholangitis (PBC) are autoimmune diseases that may occur concomitantly and are both strongly associated with disease-specific autoantibodies. This study investigated the prevalence and fine specificity of PBC-specific serology (PBC-Ab) and associations with the SSc-subtypes and SSc-specific antibodies as well as the association with cholestatic liver enzymes. Furthermore, three different techniques for the detection of PBC-Ab were compared.

Methods
Serum of 184 Belgian SSc patients with a known SSc-antibody profile, was analyzed for PBC-Ab (antimitochondrial antibodies [AMA], anti-Gp210, anti-Sp100 and anti-PML) using indirect immunofluorescence (IIF) analysis on human epithelioma-2000 (HEp-2000) cells (ANA-IIF, Immunoconcepts) and liver-kidney-stomach tissue sections (IIF-LKS) (Menarini), and a line immunoblot (LB) (EuroImmun). Alkaline phosphatase/γ-glutamyl transferase (ALP/GGT) were evaluated at time of first sampling (t0) and after 3 years of follow-up (t3).

Results
PBC-Ab were present in 13% of patients and significantly correlated with centromere antibodies (anti-CENP-B), but not correlated with the limited cutaneous SSc subgroup (lcSSc). The most frequent reactivities were AMA (11%, with 9% AMA-M2) and Sp-100 antibodies (5%), showing a major overlap. There was no relevant association between the presence of PBC-Ab and ALP or GGT elevation at t0 nor at t3. Detection of AMA with IIF-LKS is comparable to LB. ANA-IIF screening was less sensitive compared to LB.

Conclusions
A wide range of PBC-Ab is detectable in SSc in the absence of cholestatic liver enzyme elevations, even after 3 years of follow-up. However, as these antibodies may precede PBC-disease up to 10 years further prospective follow-up of our cohort will be necessary.