bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computed tomographic appearance of circumcaval and circumuterine ureter in a cat
Authors: Jirasakul Jitrapun , Thammasiri Ninlawan , Darawiroj Damri , Choisunirachon Nan , Thanaboonnipat Chutimon 
Published: April 2020

AbstractBackgroundCircumcaval ureter is a rare congenital anomaly resulting from the persistence of embryonic venous system. This anomaly is characterized by running of affected ureter around caudal vena cava (CVC).Case presentationIn this report, circumcaval ureter was found in a 2‐year‐old female cat attending as normal sample group in another research. This cat passed all health checkup protocols before computed tomography (CT) was performed.ConclusionThe contrast‐enhanced computed tomographic (cCT) images clearly revealed the dislocation of the right ureter that course around CVC and uterine body. This is the first report of feline circumcaval concurrent with circumuterine ureter detected by cCT.
Temporal association rule mining: An overview considering the time variable as an integral or implied component
Authors: Segura‐Delgado Alberto , Gacto María José , Alcalá Rafael , Alcalá‐Fdez Jesús 
Published: April 2020

AbstractAssociation rules are commonly used to provide decision‐makers with knowledge that helps them to make good decisions. Most of the published proposals mine association rules without paying particular attention to temporal information. However, in real‐life applications data usually change over time or presenting different temporal situations. Therefore, the extracted knowledge may not be useful, since we may not know whether the rules are currently applicable or whether they will be applicable in the future. For this reason, in recent years, many methods have been proposed in the literature for mining temporal association rules, which introduce a greater predictive and descriptive power providing an additional degree of interestingness. One of the main problems in this research field is the lack of visibility most works suffer since there is no standard terminology to refer to it, making it difficult to find and compare proposals and studies in the field. This contribution attempts to offer a well‐defined framework that allows researchers both to easily locate the previous proposals and to propose well‐grounded methods in the future. To accomplish both objectives, a two‐level taxonomy is proposed according to whether the time variable is considered to provide order to the data collection and to locate some temporal constraints, or whether it is considered as an attribute within the learning process. Some recent applications, available software tools, and a bibliographical analysis in accordance with the Web of Science are also shown. Finally, some critical considerations and potential further directions are discussed.This article is categorized under:
Technologies > Association Rules
Algorithmic Development > Association Rules
Lupus erythematodes – ein klinisch-pathologisch heterogenes Krankheitsbild
Authors: Obermoser Gerlinde , Zelger Bettina , Zelger Bernhard 
Published: April 2020

ZusammenfassungDer Lupus erythematodes (LE) ist eine Autoimmunerkrankung, bei der die Immuntoleranz gegenüber Nukleinsäuren verloren geht und es unter anderem durch ein enthemmtes Typ-I-Interferon-System zu einer chronischen Immunaktivierung kommt. Geradezu typisch für den LE ist seine große Heterogenität von klinischen Symptomen und Verläufen zwischen Patienten. Die LE-Manifestationen auf der Haut können mit Beteiligung innerer Organe verbunden sein oder auch isoliert auftreten und nicht selten einem systemischen Lupus erythematodes vorausgehen. Eine sorgfältige Untersuchung und Beobachtung des klinischen Verlaufs ist daher wichtig. Die Erscheinungsformen des LE auf der Haut umfassen ein weites Spektrum. Dies macht es schwierig, die verschiedenen Hauterscheinungen zu klassifizieren, um z. B. Ansprechen auf neue Therapieformen zu messen. In diesem Übersichtsartikel werden die wichtigsten Hautmanifestationen des LE mit klinischer Präsentation und Histopathologie behandelt.
Diagnostic accuracy of CT pulmonary angiography in suspected pulmonary hypertension
Authors: Swift Andrew J. , Dwivedi Krit , Johns Chris , Garg Pankaj , Chin Matthew , Currie Ben J , Rothman Alex MK , Capener Dave , Shahin Yousef , Elliot Charlie A , Charalampopolous Thanos , Sabroe Ian , Rajaram Smitha , Hill Catherine , Wild Jim M. , Condliffe Robin , Kiely David G. 
Published: April 2020

Abstract
Objectives
Computed tomography (CT) pulmonary angiography is widely used in patients with suspected pulmonary hypertension (PH). However, the diagnostic and prognostic significance remains unclear. The aim of this study was to (a) build a diagnostic CT model and (b) test its prognostic significance.

Methods
Consecutive patients with suspected PH undergoing routine CT pulmonary angiography and right heart catheterisation (RHC) were identified. Axial and reconstructed images were used to derive CT metrics. Multivariate regression analysis was performed in the derivation cohort to identify a diagnostic CT model to predict mPAP ≥ 25 mmHg (the existing ESC guideline definition of PH) and > 20 mmHg (the new threshold proposed at the 6th World Symposium on PH). In the validation cohort, sensitivity, specificity and compromise CT thresholds were identified with receiver operating characteristic (ROC) analysis. The prognostic value of the CT model was assessed using Kaplan-Meier analysis.

Results
Between 2012 and 2016, 491 patients were identified. In the derivation cohort (n = 247), a CT model was identified including pulmonary artery diameter, right ventricular outflow tract thickness, septal angle and left ventricular area. In the validation cohort (n = 244), the model was diagnostic, with an area under the ROC curve of 0.94/0.91 for mPAP ≥ 25/> 20 mmHg respectively. In the validation cohort, 93 patients died; mean follow-up was 42 months. The diagnostic thresholds for the CT model were prognostic, log rank, all p < 0.01.

Discussion
In suspected PH, a diagnostic CT model had diagnostic and prognostic utility.

Key Points
• Diagnostic CT models have high diagnostic accuracy in a tertiary referral population of with suspected PH.
• Diagnostic CT models stratify patients by mortality in suspected PH.
Electrochemical method for isolation of chitinous 3D scaffolds from cultivated Aplysina aerophoba marine demosponge and its biomimetic application
Authors: Nowacki Krzysztof , Stępniak Izabela , Machałowski Tomasz , Wysokowski Marcin , Petrenko Iaroslav , Schimpf Christoph , Rafaja David , Langer Enrico , Richter Andreas , Ziętek Jerzy , Pantović Snežana , Voronkina Alona , Kovalchuk Valentine , Ivanenko Viatcheslav , Khrunyk Yuliya , Galli Roberta , Joseph Yvonne , Gelinsky Michael , Jesionowski Teofil , Ehrlich Hermann 
Published: April 2020

AbstractThree-dimensional (3D) biopolymer-based scaffolds including chitinous matrices have been widely used for tissue engineering, regenerative medicine and other modern interdisciplinary fields including extreme biomimetics. In this study, we introduce a novel, electrochemically assisted method for 3D chitin scaffolds isolation from the cultivated marine demospongeAplysina aerophobawhich consists of three main steps: (1) decellularization, (2) decalcification and (3) main deproteinization along with desilicification and depigmentation. For the first time, the obtained electrochemically isolated 3D chitinous scaffolds have been further biomineralized ex vivo using hemolymph ofCornu aspersumedible snail aimed to generate calcium carbonates-based layered biomimetic scaffolds. The analysis of prior to, during and post-electrochemical isolation samples as well as samples treated with molluscan hemolymph was conducted employing analytical techniques such as SEM, XRD, ATR–FTIR and Raman spectroscopy. Finally, the use of described method for chitin isolation combined with biomineralization ex vivo resulted in the formation of crystalline (calcite) calcium carbonate-based deposits on the surface of chitinous scaffolds, which could serve as promising biomaterials for the wide range of biomedical, environmental and biomimetic applications.
The occipital face area is causally involved in identity-related visual-semantic associations
Authors: Eick Charlotta Marina , Kovács Gyula , Rostalski Sophie-Marie , Röhrig Lisa , Ambrus Géza Gergely 
Published: April 2020

AbstractFaces are processed in a network of areas within regions of the ventral visual stream. However, familiar faces typically are characterized by additional associated information, such as episodic memories or semantic biographical information as well. The acquisition of such non-sensory, identity-specific knowledge plays a crucial role in our ability to recognize and identify someone we know. The occipital face area (OFA), an early part of the core face-processing network, is recently found to be involved in the formation of identity-specific memory traces but it is currently unclear if this role is limited to unimodal visual information. The current experiments used transcranial magnetic stimulation (TMS) to test whether the OFA is involved in the association of a face with identity-specific semantic information, such as the name or job title of a person. We applied an identity-learning task where unfamiliar faces were presented together with a name and a job title in the first encoding phase. Simultaneously, TMS pulses were applied either to the left or right OFA or to Cz, as a control. In the subsequent retrieval phase, the previously seen faces were presented either with two names or with two job titles and the task of the participants was to select the semantic information previously learned. We found that the stimulation of the right or left OFA reduced subsequent retrieval performance for the face-associated job titles. This suggests a causal role of the OFA in the association of faces and related semantic information. Furthermore, in contrast to prior findings, we did not observe hemispherical differences of the TMS intervention, suggesting a similar role of the left and right OFAs in the formation of the visual-semantic associations. Our results suggest the necessity to reconsider the hierarchical face-perception models and support the distributed and recurrent models.
Impact of circulating tumor DNA in hepatocellular and pancreatic carcinomas
Authors: Dhayat Sameer A. , Yang Zixuan 
Published: April 2020

AbstractHepatocellular carcinoma (HCC) and pancreatic cancer (PC) belong to the most lethal malignancies worldwide. Despite advances in surgical techniques and perioperative multidisciplinary management, the prognosis of both carcinoma entities remains poor mainly because of rapid tumor progression and early dissemination with diagnosis in advanced tumor stages with poor sensitivity to current therapy regimens. Both highly heterogeneous visceral carcinomas exhibit unique somatic alterations, but share common driver genes and mutations as well. Recently, circulating tumor DNA (ctDNA) could be identified as a liquid biopsy tool with huge potential as non-invasive biomarker in early diagnosis and prognosis. CtDNA released from necrotic or apoptotic cells of primary tumors, metastasis, and circulating tumor cells can reveal genetic and epigenetic alterations with tumor-specific and individual mutation and methylation profiles. In this article, we focus on clinical impact of ctDNA as potential biomarker in patients with HCC and PC.
Entwicklung einer psychoanalytisch begründeten Typologie von psychotischen Erkrankungen
Authors: Sell Christian , Henkel Miriam , Grant Phillip , von Haebler Dorothea , Dümpelmann Michael , Ohlmeier Martin , Schnell Knut , Spitzer Carsten , Mardus Bettina , Benecke Cord 
Published: April 2020

ZusammenfassungDer Artikel begründet die Notwendigkeit eines genuin psychoanalytischen und gleichsam in der empirischen Psychotherapieforschung anschlussfähigen Beitrags zum Verständnis psychotischer Erkrankungen. Die sequenziell erklärende Mixed-Methods-Studie „Therapie und Psychodynamik von Patient*innen mit psychotischen Symptomen“ (T3PS-Studie) fokussiert auf die Binnendifferenzierung psychotischer Erkrankungen. Hierfür soll eine psychoanalytisch begründete Typologie dieser Patient*innen anhand messender und hermeneutischer Methoden entwickelt und validiert werden. Zur Entwicklung der Typologie sieht das Studiendesign psychodynamische, psychopathologische und weitere diagnostische Interviews mit stationären Patientinnen und Patienten (N = 100) vor. Zusätzlich werden am Ende der Behandlung Beziehungsepisodeninterviews mit Mitgliedern des Behandlungsteams geführt und Fragebogen eingesetzt. Mittels zunächst statistischer Modellierung und anschließender qualitativer Konzeptbildung sollen schließlich Prototypen psychotischer Erkrankungen entlang der in der Operationalisierten Psychodynamischen Diagnostik (OPD) erfassbaren psychoanalytischen Konzepte von Konflikt, Struktur und Beziehungsdynamik identifiziert werden. Die klinische Nützlichkeit dieser Typologie soll durch systematische Untersuchungen einzelner Behandlungsverläufe nach dem Hermeneutic Single-Case Efficacy Design (HSCED) geprüft werden.
Drains result in greater reduction of subdural width and midline shift in burr hole evacuation of chronic subdural haematoma
Authors:   on behalf of the British Neurosurgical Trainee Research Collaborative (BNTRC), Glancz Laurence Johann , Poon Michael Tin Chung , Hutchinson Peter John , Kolias Angelos Georgiou , Brennan Paul Martin 
Published: April 2020

Abstract
Background
Drain insertion following chronic subdural haematoma (CSDH) evacuation reduces recurrence and improves outcomes. The mechanism of this improvement is uncertain. We assessed whether drains result in improved postoperative imaging, and which radiological factors are associated with recurrence and functional outcome.

Methods
A multi-centre, prospective cohort study of CSDH patients was performed between May 2013 and January 2014. Patients aged > 16 years undergoing burr hole evacuation of primary CSDH with pre- and postoperative imaging were included in this subgroup analysis. Baseline and clinical details were collected. Pre- and postoperative maximal subdural width and midline shift (MLS) along with clot density were recorded. Primary outcomes comprised mRS at discharge and symptomatic recurrence requiring re-drainage. Comparisons were made using multiple logistic regression.

Results
Three hundred nineteen patients were identified for inclusion. Two hundred seventy-two of 319 (85%) patients underwent drain insertion at the time of surgery versus 45/319 (14%) who did not. Twenty-nine of 272 patients who underwent drain insertion experienced recurrence (10.9%) versus 9 of 45 patients without drain insertion (20.5%; p = 0.07). Overall change in median subdural width was significantly greater in the drain versus ‘no drain’ groups (11 mm versus 6 mm, p < 0.01). Overall change in median midline shift (MLS) was also significantly greater in the drain group (4 mm versus 3 mm, p < 0.01). On multivariate analysis, change in maximal width and MLS were significant predictors of recurrence, although only the former remained a significant predictor for functional outcome.

Conclusions
The use of subdural drains results in significantly improved postoperative imaging in burr hole evacuation of CSDH, thus providing radiological corroboration for their recommended use.
Design of a Flexible, User Friendly Feature Matrix Generation System and its Application on Biomedical Datasets
Authors: Ghorbani M. , Swift S. , Taylor S. J. E. , Payne A. M. 
Published: April 2020

AbstractThe generation of a feature matrix is the first step in conducting machine learning analyses on complex data sets such as those containing DNA, RNA or protein sequences. These matrices contain information for each object which have to be identified using complex algorithms to interrogate the data. They are normally generated by combining the results of running such algorithms across various datasets from different and distributed data sources. Thus for non-computing experts the generation of such matrices prove a barrier to employing machine learning techniques. Further since datasets are becoming larger this barrier is augmented by the limitations of the single personal computer most often used by investigators to carry out such analyses. Here we propose a user friendly system to generate feature matrices in a way that is flexible, scalable and extendable. Additionally by making use of The Berkeley Open Infrastructure for Network Computing (BOINC) software, the process can be speeded up using distributed volunteer computing possible in most institutions. The system makes use of a combination of the Grid and Cloud User Support Environment (gUSE), combined with the Web Services Parallel Grid Runtime and Developer Environment Portal (WS-PGRADE) to create workflow-based science gateways that allow users to submit work to the distributed computing. This report demonstrates the use of our proposed WS-PGRADE/gUSE BOINC system to identify features to populate matrices from very large DNA sequence data repositories, however we propose that this system could be used to analyse a wide variety of feature sets including image, numerical and text data.
Bee species decrease and increase between the 1990s and 2018 in large urban protected sites
Authors: Hofmann Michaela M. , Renner Susanne S. 
Published: April 2020

AbstractPrevious work has shown that among 428 species of bees occurring in Germany, decline or extinction over the past 40 years have been correlated with late-season emergence and restricted habitats, while other factors, such as pollen specialization, body size, nesting sites, and sociality, played no role in models that included a phylogeny of these bees. Doing best are spring-flying, city-dwelling species. Building on these results, we here investigate changes in bee diversity from the 1990s to 2018 at three protected sites within the city perimeter of Munich, focusing on the correlates of flight season (spring or summer), flight duration (in months), and number of habitats (one or two vs. three to six). Local species pools were assessed against the total species pool from 1795 onwards. Twenty years ago, 150 species were present at one or more of the sites, while in 2017/2018, this was true of 188 species, with the increase at two sites being of similar proportion. In two of the three areas, broad habitat use was positively correlated with persistence. Flight season or duration had no statistical effect. These results underscore the function of urban protected sites in bee conservation and imply that summer food shortages, which negatively affect bees in agricultural areas, play no role in urbanized regions so that late-season flight is not an extinction handicap.
Motive Satisfaction in Chronic Pain Patients: Does It Improve in Multidisciplinary Inpatient Treatment and, if so, Does It Matter?
Authors: Vincent Alessia M. , Stewart Julian A. , Egloff Niklaus , grosse Holtforth Martin 
Published: April 2020

AbstractAccording to consistency theory, insufficient motive satisfaction (motivational incongruence) is associated with psychological distress and mental disorders. High levels of distress and comorbid psychological disorders are common in patients with chronic pain. The aim of the present study was to investigate the role of motivational incongruence in chronic pain patients and the association of incongruence change with symptom improvement. Inpatients with chronic pain in multimodal interdisciplinary treatment (n = 177) completed questionnaires measuring motivational incongruence, psychological distress, pain intensity and pain interference at the beginning and end of a multimodal interdisciplinary inpatient treatment program at a tertiary psychosomatic university clinic. Results demonstrated that pain and motivational incongruence were significantly reduced at post-treatment, and reductions in incongruence were associated with reductions in psychological distress. In particular, better satisfaction of approach motives mediated the association between reduction of pain interference and psychological distress at post-treatment. Findings suggest that a reduction of motivational incongruence may be part of successful treatment of chronic pain.
Thermal imaging for detecting temperature changes within the rheumatoid foot
Authors: Gizińska Małgorzata , Rutkowski Radosław , Szymczak-Bartz Lucyna , Romanowski Wojciech , Straburzyńska-Lupa Anna 
Published: April 2020

AbstractThe study reports the development of a thermal imaging method suitable for the screening and differentiation of joint inflammation in the rheumatoid foot of patients in comparison with the control group of healthy participants. The study included 81 patients, with rheumatoid arthritis (RA), and 39 healthy volunteers without any signs or symptoms of inflammation. The feet joints were examined by ultrasonography, and the surface temperature of the dorsal side of the foot was measured using a thermovision camera. Significant differences in mean temperatures between the study group and the control group were found. At the same time, there were no statistically significant differences between the mean temperatures in the left and right foot in any of the designated regions in the study and control group. The comparison of average temperatures of joints with or without inflammation, according to ultrasonography, did not show significance except for two joints. Despite the lack of statistical differences in the recorded temperatures, changes in the form of spikes, hot spots, and gradation of the temperatures during screening were observed. Screening analysis of the temperature distribution of the foot can aid in the diagnosis of RA and in the evaluation of the development of the disease. Additional studies must be conducted to confirm the results of this study.
Uniting epistemological perspectives to support contextualized knowledge development
Authors: van der Linden Sara , McKenney Susan 
Published: April 2020

AbstractThe nature of knowledge and how it is developed have been debated in philosophy and research for centuries. In the literature on teachers’ knowledge, two perspectives have been particularly visible. One perspective stresses cognitive processes and deliberate knowledge acquisition. Another perspective stresses the situated nature of teachers’ learning and knowledge development through awareness. This theoretical article proposes that uniting both epistemological perspectives is beneficial for developing teachers’ contextualized knowledge of how to teach at all phases of career development, and especially early on. In so doing, action and reflection are positioned as central to the development of teachers’ knowledge, and affordances from both the deliberate and the aware perspectives are articulated. Specifically, this article explains why uniting the two perspectives supports better sense-making, more refined instructional planning, and more responsive teaching, before offering a united reflection model. These processes are then discussed in the context of video coaching interventions for early-career teachers. After presenting a blueprint for video-based reflection and key design features that could support teachers’ learning, important differences compared to other reflection models are discussed and implications for (the design of) teachers' professional development based upon this united perspective are presented.