bluuebunny/crossref_metadata_2025_split huggingface dataset:
Codependency between plant and arbuscular mycorrhizal fungal communities: what is the evidence?
Authors: Kokkoris Vasilis , Lekberg Ylva , Antunes Pedro M. , Fahey Catherine , Fordyce James A. , Kivlin Stephanie N. , Hart Miranda M. 
Published: May 2020

SummaryThat arbuscular mycorrhizal (AM) fungi covary with plant communities is clear, and many papers report nonrandom associations between symbiotic partners. However, these studies do not test the causal relationship, or ‘codependency’, whereby the composition of one guild affects the composition of the other. Here we outline underlying requirements for codependency, compare important drivers for both plant and AM fungal communities, and assess how host preference – a pre‐requisite for codependency – changes across spatiotemporal scales and taxonomic resolution for both plants and AM fungi. We find few examples in the literature designed to test for codependency and those that do have been conducted within plots or mesocosms. Also, while plants and AM fungi respond similarly to coarse environmental filters, most variation remains unexplained, with host identity explaining less than 30% of the variation in AM fungal communities. These results combined question the likelihood of predictable co‐occurrence, and therefore evolution of codependency, between plant and AM fungal taxa across locations. We argue that codependency is most likely to occur in homogeneous environments where specific plant – AM fungal pairings have functional consequences for the symbiosis. We end by outlining critical aspects to consider moving forward.
Sedimentological and palaeoenvironmental study from Waregi Hill in the Hiwegi Formation (early Miocene) on Rusinga Island, Lake Victoria, Kenya
Authors: Michel Lauren A. , Lehmann Thomas , Mcnulty Kieran P. , Driese Steven G. , Dunsworth Holly , Fox David L. , Harcourt‐Smith William E.H. , Jenkins Kirsten , Peppe Daniel J. 
Published: May 2020

AbstractPalaeontological deposits on Rusinga Island, Lake Victoria, Kenya, provide a rich record of floral and faunal evolution in the early Neogene of East Africa. Yet, despite a wealth of available fossil material, previous palaeoenvironmental reconstructions from Rusinga have resulted in widely divergent results, ranging from closed forest to open woodland environments. Presented here is a detailed study of the sedimentology and fauna of the early Miocene Hiwegi Formation at Waregi Hill on Rusinga Island, Kenya. New sedimentological analyses demonstrate that the Hiwegi Formation records an environmental transition from the bottom to the top of the formation. Lower in the Hiwegi Formation, satin‐spar calcite after gypsum in siltstone deposits are interpreted as evidence for open hypersaline lakes. Moving up‐section, carbonate deposits – interpreted previously as evidence of aridity – are actually diagenetic calcite cements, which preserve root systems of trees, suggesting a more closed environment; further up‐section, the uppermost palaeosol layer contains abundant root traces and tree‐stump casts, previously reported as evidence of a closed‐canopy forest. These newly interpreted environmental differences are reflected by differences in faunal composition and abundance data from Hiwegi Formation fossil sites R1 and R3. Taken together, this work suggests that divergent palaeoenvironmental reconstructions in previous studies may have been informed by time‐averaging across multiple environments. Further, results demonstrate that during the early Miocene local or regional habitat heterogeneity already existed. Rusinga’s Hiwegi Formation varied both spatially and temporally, which challenges the interpretation that a broad forested environment stretched across the African continent during the early Neogene, transitioning later to predominately open landscapes that characterize the region today. This result has important implications for interpretations of the selective pressures faced by early Miocene fauna, including Rusinga Island’s well‐preserved fossil primates.
Carboplatin‐induced myelosuppression as related to body weight in dogs
Authors: Coffee Calli , Roush James K. , Higginbotham Mary Lynn 
Published: May 2020

AbstractSmaller dogs are known to have an increased risk of chemotherapy‐induced myelosuppression for doxorubicin, mitoxantrone and melphalan. This retrospective study aimed to determine if dogs <15 kg and <10 kg experienced greater degrees of myelosuppression following treatment with carboplatin chemotherapy compared with dogs ≥15 kg. One hundred and one dogs treated with carboplatin for a variety of malignancies were retrospectively analysed. Eight dogs (61%) weighing <10 kg, three (38%) weighing 10 kg to <15 kg and 14 (17%) weighing ≥15 kg experienced a grade 3 or 4 neutropenia. Five dogs (38%) weighing <10 kg, two (25%) weighing 10 kg to <15 kg and 13 (16%) weighing ≥15 kg experienced a grade 3 or 4 thrombocytopenia. Dogs <10 kg were significantly more likely to develop a grade 3 or 4 neutropenia following carboplatin than dogs ≥10 kg (3.5 RR; 95% CI, 1.9‐6.3;P < .001). Dogs <15 kg were also significantly more likely to develop a grade 3 or 4 neutropenia than dogs ≥15 kg (3 RR; 95% CI, 1.6‐5.6;P= .004). Dogs <10 kg were significantly more likely to develop a grade 3 or 4 thrombocytopenia than those dogs ≥10 kg (2.5 RR; 95% CI, 1.1‐5.6;P= .006). Hospitalization was significantly more likely for dogs <10 kg vs ≥10 kg (P= .014) as well as for dogs <15 kg vs ≥15 kg (P= .039). This study demonstrates an increased risk of carboplatin‐induced myelosuppression in dogs <15 kg, and particularly those <10 kg. This information should be considered by clinicians when making decisions regarding the initial carboplatin dose for smaller canine patients, especially those <15 kg.
Adaptations in GLUT4 Expression in Response to Exercise Detraining Linked to Downregulation of Insulin-Dependent Pathways in Cardiac but not in Skeletal Muscle Tissue
Authors: Lehnen Alexandre M. , Pinto Graziela H. , Borges Júlia , Markoski Melissa M. , Schaan Beatriz D. 
Published: May 2020

Insulin resistance is associated with cardiometabolic risk factors, and exercise training can improve insulin-mediated glucose uptake. However, few studies have demonstrated the reversibility of exercise-induced benefits. Thus, the authors examine the time–response effects of exercise training and detraining on glucose transporter 4 (GLUT4) content, insulin-dependent and insulin-independent pathways in cardiac and gastrocnemius muscle tissues of spontaneously hypertensive rats. Thirty-two male spontaneously hypertensive rats, 4 months old, were assigned to (n = 8/group): T (exercise training: 10-week treadmill exercise, 50–70% maximum effort capacity, 1 hr/day, 5 days/week); D2 (exercise training + 2-day detraining), D4 (exercise training + 4-day detraining); and S (no exercise). The authors evaluated insulin resistance, maximum effort capacity, GLUT4 content, p-IRS-1Tyr1179, p-AS160Ser588, p-AMPKα1Thr172, and p-CaMKIIThr286 in cardiac and gastrocnemius muscle tissues (Western blot). In response to exercise training, there were improvements in insulin resistance (15.4%; p = .010), increased GLUT4 content (microsomal, 29.4%; p = .012; plasma membrane, 27.1%; p < .001), p-IRS-1 (42.2%; p < .001), p-AS160 (60.0%; p < .001) in cardiac tissue, and increased GLUT4 content (microsomal, 29.4%; p = .009; plasma membrane, 55.5%; p < .001), p-IRS-1 (28.1%; p = .018), p-AS160 (76.0%; p < .001), p-AMPK-α1 (37.5%; p = .026), and p-CaMKII (30.0%; p = .040) in the gastrocnemius tissue. In D4 group, the exercise-induced increase in GLUT4 was reversed (plasma membrane, −21.3%; p = .027), p-IRS1 (−37.1%; p = .008), and p-AS160 (−82.6%; p < .001) in the cardiac tissue; p-AS160 expression (−35.7%; p = .034) was reduced in the gastrocnemius. In conclusion, the cardiac tissue is more susceptible to exercise adaptations in the GLUT4 content and signaling pathways than the gastrocnemius muscle. This finding may be explained by particular characteristics of insulin-dependent and insulin-independent pathways in the muscle tissues studied.
Scope, quality, and inclusivity of clinical guidelines produced early in the covid-19 pandemic: rapid review
Authors: Dagens Andrew , Sigfrid Louise , Cai Erhui , Lipworth Sam , Cheng Vincent , Harris Eli , Bannister Peter , Rigby Ishmeala , Horby Peter 
Published: May 2020

AbstractObjectiveTo appraise the availability, quality, and inclusivity of clinical guidelines produced in the early stage of the coronavirus disease 2019 (covid-19) pandemic.DesignRapid review.Data sourcesOvid Medline, Ovid Embase, Ovid Global Health, Scopus, Web of Science Core Collection, and WHO Global Index Medicus, searched from inception to 14 Mar 2020. Search strategies applied the CADTH database guidelines search filter, with no limits applied to search results. Further studies were identified through searches of grey literature using the ISARIC network.Inclusion criteriaClinical guidelines for the management of covid-19, Middle East respiratory syndrome (MERS), and severe acute respiratory syndrome (SARS) produced by international and national scientific organisations and government and non-governmental organisations relating to global health were included, with no exclusions for language. Regional/hospital guidelines were excluded. Only the earliest version of any guideline was included.Quality assessmentQuality was assessed using the Appraisal of Guidelines for Research and Evaluation (AGREE) II tool. The quality and contents of early covid-19 guidelines were also compared with recent clinical guidelines for MERS and SARS.Results2836 studies were identified, of which 2794 were excluded after screening. Forty two guidelines were considered eligible for inclusion, with 18 being specific to covid-19. Overall, the clinical guidelines lacked detail and covered a narrow range of topics. Recommendations varied in relation to, for example, the use of antiviral drugs. The overall quality was poor, particularly in the domains of stakeholder involvement, applicability, and editorial independence. Links between evidence and recommendations were limited. Minimal provision was made for vulnerable groups such as pregnant women, children, and older people.ConclusionsGuidelines available early in the covid-19 pandemic had methodological weaknesses and neglected vulnerable groups such as older people. A framework for development of clinical guidelines during public health emergencies is needed to ensure rigorous methods and the inclusion of vulnerable populations.Systematic review registrationPROSPERO CRD42020167361.
Rapid systematic review of neonatal COVID-19 including a case of presumed vertical transmission
Authors: Gordon Morris , Kagalwala Taher , Rezk Karim , Rawlingson Chris , Ahmed M Idris , Guleri Achyut 
Published: May 2020

ObjectiveTo carry out a systematic review of the available studies on COVID-19 (coronavirus disease 2019) in neonates seen globally since the onset of the COVID-19 global pandemic in 2020. The paper also describes a premature baby with reverse transcription (RT)-PCR-positive COVID-19 seen at the Blackpool Teaching Hospitals NHS Foundation Trust, UK.DesignWe conducted a multifaceted search of the Cumulative Index to Nursing and Allied Health Literature, Embase, Medline and PubMed from 1 December 2019 to 12 May 2020 to harvest articles from medical journals and publications reporting cases of COVID-19 in neonates from anywhere in the world. Additional searches were also done so as not to miss any important publications. Write-up was in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, the protocol for the review was registered with International Prospective Register of Systematic Reviews (PROSPERO), and risk of bias was analysed with the Newcastle-Ottawa tool. Additionally, the preterm neonate with COVID-19 from our hospital is also reported.ResultsThe systematic review has revealed eight studies where neonates have been described to have confirmed COVID-19, with low risk of bias. Of the 10 reported cases elsewhere, only three are likely to be vertically transmitted, while seven occurred in the postperinatal period and are likely to have been postnatally acquired. All neonates had a mild course, recovered fully and were negative on retesting. Our case of COVID-19 in a 32-week premature baby from the UK was delivered by emergency caesarean section, with the mother wearing a face mask and the family having no contact with the neonate, suggesting vertical transmission. On day 33, the neonate was asymptomatic but was still RT-PCR-positive on nasopharyngeal airway swab.ConclusionsNeonatal infection is uncommon, with only two previously reported cases likely to be of vertical transmission. The case we report is still RT-PCR-positive on day 28 and is asymptomatic. Ongoing research is needed to ascertain the epidemiology of COVID-19 in neonates.
Triage imaging and outcome measures for large core stroke thrombectomy – a systematic review and meta-analysis
Authors: Sarraj Amrou , Grotta James C , Pujara Deep Kiritbhai , Shaker Faris , Tsivgoulis Georgios 
Published: May 2020

BackgroundTrials of endovascular thrombectomy (EVT) mostly excluded patients with large core strokes so the safety and efficacy of EVT is not well established in such patients. Moreover, the definition of large core and its measurement differ between semi-quantitative (ASPECTS) and quantitative (core volume) imaging modalities. We evaluated functional and safety outcomes in studies reporting large core stroke patients treated with EVT and compared them with patients treated with medical management (MM) only.MethodsA systemic search using three large databases was performed to identify studies evaluating functional and safety outcomes in patients with large core strokes (ASPECTS<6 or core volume ≥50 cc) on CT, MRI, and Perfusion imaging according to PRISMA guidelines. A random-effect meta-analysis model was used to pool reported outcomes.ResultsTwelve studies reporting outcomes for patients treated with EVT compared with MM in large core strokes were included. A pooled random-effect meta-analysis of large core patients by either definition (ASPECTS <6 or ischemic core volume ≥50 cc or both) demonstrated increased functional independence (mRS-scores 0–2) rates with EVT (EVT: 122/491 (25%), MM: 45/691 (7%), pooled OR: 4.39 [95% CI: 2.53 to 7.64], overall effect Z-score: 5.25, P<0.00001, I2=37%, P for Cochran Q:0.15) and decreased mortality (EVT: 101/439 (23%), MM: 215/645 (33%), pooled OR:0.53 [95% CI: 0.40 to 0.71], overall effect Z-score:4.32, P<0.0001, I2=0%, P for Cochran Q:0.78) at 90 days, without significant increase in symptomatic intracranial hemorrhage (ICH) (EVT: 42/462 (9%), MM: 35/663 (5%), pooled OR: 1.68 [95% CI: 0.92 to 3.09], overall effect Z-score:1.68, P=0.09, I2=26%, P for Cochran Q:0.24). Similar effects were observed in studies reporting large core outcomes based on ASPECTS <6 and ischemic core volume ≥50 cc. We observed no heterogeneity between quantitative vs semi-quantitative large core definitions, different ischemic core thresholds, and studies reporting outcomes over different time windows in subgroup analyses.ConclusionIn large core stroke patients, EVT is associated with improved functional independence and lower mortality at 90 days without significant increase in symptomatic ICH across various definitions, thresholds of large core size, and time windows. Further randomized evidence is warranted to establish EVT efficacy and safety in this population.
Distal anterior cerebral artery aneurysms treated with flow diversion: experience of a large-volume center and systematic review of the literature
Authors: Cagnazzo Federico , Fanti Andrea , Lefevre Pierre-Henri , Derraz Imad , Dargazanli Cyril , Gascou Gregory , Riquelme Carlos , Ahmed Raed , Bonafe Alain , Costalat Vincent 
Published: May 2020

BackgroundEvidence about the safety and the efficacy of flow diversion for distal anterior cerebral artery (DACA) aneurysms is scant. To provide further insight into flow diversion for aneurysms located at, or distal to, the A2 segment.MethodsConsecutive patients receiving flow diversion for DACA aneurysms were retrieved from our prospective database (2014–2020). A PRISMA guidelines-based systematic review of the literature was performed. Aneurysm occlusion (O’Kelly–Marotta=OKM) and clinical outcomes were evaluated.ResultsTwenty-three patients and 25 unruptured saccular DACA aneurysms treated with flow diversion were included. Aneurysm size ranged from 2 mm to 9 mm (mean size 4.5 mm, SD ±1.6). Mean parent artery diameter was 1.8 mm (range, 1.2–3 mm, SD ±0.39). Successful stent deployment was achieved in all cases. Angiographic adequate occlusion (OKM C–D) at follow-up (14 months) was 79% (19/24 available aneurysms). No cases of aneurysm rupture or retreatment were reported. Univariate analysis showed a significant difference in diameter among aneurysms with adequate (4 mm) vs incomplete occlusion (7 mm) (P=0.006).There was one transient perioperative in-stent thrombosis, and three major events causing neurological morbidity: two stent thromboses (one attributable to the non-adherence of the patient to the antiplatelet therapy); and one acute occlusion of a covered calloso-marginal artery.Results from systematic review (12 studies and 107 A2–A3 aneurysms) showed 78.6% (95% CI=70–86) adequate occlusion, 7.5% (95% CI=3.6–14) complications, and 2.8%, (3/107, 95% CI=0.6–8.2) morbidity.ConclusionsFlow diversion among DACA aneurysms is effective, especially among small lesions. However, potential morbidity related to in-stent thrombosis and covered side branches should be considered when planning this strategy.
Flow modification on the internal carotid artery bifurcation region and A1 segment after M1-internal carotid artery flow diverter deployment
Authors: Cagnazzo Federico , Ahmed Raed , Lefevre Pierre-Henri , Derraz Imad , Dargazanli Cyril , Gascou Gregory , Riquelme Carlos , Frandon Julien , Bonafe Alain , Costalat Vincent 
Published: May 2020

BackgroundClinical and hemodynamic consequences of flow diverters extending from the M1 to the internal carotid artery (ICA), covering the A1 segment, have rarely been investigated. We aimed to provide angiographic and clinical data about flow modifications on the covered A1.MethodsConsecutive patients receiving M1-ICA flow diverters for unruptured aneurysms were collected from our prospective database (2014–2020).Results42 A1 arteries covered with a single device were studied. All patients had an angiographic detected contralateral flow from the anterior communicating artery (AcomA). Immediately after flow diversion, 20 (47.6%) covered A1 showed slow flow. During a mean angiographic follow-up of 14 months, 13 (31%) and 22 (52.3%) A1 arteries were occluded and narrowed, respectively. Flow changes were asymptomatic in all cases. Vascular risk factors, sex, oversized compared with not oversized stents, immediate A1 slow flow, age, diameter of the A1, length of follow-up, and platelet inhibition rate were tested as prognosticators of A1 occlusion. Length of the angiographic follow-up was the only predictor of A1 occlusion (p=0.005, OR=3, CI=1.4 to 6.7). There were two device related ischemic events with a 2.3% rate of morbidity (one basal ganglia infarct after coverage of the M1 perforators and one transient acute instent thrombosis).ConclusionsCovering the A1 segment during M1-ICA flow diversion seems relatively safe, if the contralateral flow is assured by the AcomA. Approximately 31% and 52% of the covered A1 showed asymptomatic occlusions and narrowing, respectively. The likelihood of flow modification was proportional to the length of follow-up. Morbidity associated with flow diversion in the ICA terminus region was 2.3%.
Evasion of HSR in the charmless decays of excited P-wave charmonia
Authors: Wang Yan , Wu Qi , Li Gang , Xie Ju-Jun , An Chun-Sheng 
Published: May 2020

AbstractWe investigate the charmless decays of excited P-wave charmonia $$\chi _{c1}^\prime \rightarrow VV$$χc1′→VV and $$\chi _{c2}^\prime \rightarrow VP$$χc2′→VP via intermediate charmed meson loops, where V and P denote the light vector and pseudoscalar mesons, respectively. Within the model parameters, the charmed meson loop contributions are evaluated by using the effective Lagrangian approach. For $$\chi _{c1}^\prime \rightarrow VV$$χc1′→VV, the partial widths of the $$\rho \rho $$ρρ, $$\omega \omega $$ωω, and $$K^*{\bar{K}}^*$$K∗K¯∗ channels can reach to the order of MeV, while the partial width of the $$\phi \phi $$ϕϕ channel is very small and in the order of keV. For $$\chi _{c2}^\prime \rightarrow V P$$χc2′→VP, the partial widths of $$\chi _{c2}^{\prime } \rightarrow K^*\bar{K}+c.c$$χc2′→K∗K¯+c.c turns out to be sizeable, while the partial widths of $$\chi _{c2}^{\prime } \rightarrow \rho ^+\pi ^- +c.c$$χc2′→ρ+π-+c.c is found to be much smaller than the $$K^*\bar{K}+c.c$$K∗K¯+c.c channel. Our calculations may be examined by the future BESIII experiments.
GUP black hole remnants in quadratic gravity
Authors: Kuntz Iberê , da Rocha Roldão 
Published: May 2020

AbstractThe Hawking radiation of static, spherically symmetric, asymptotically flat solutions in quadratic gravity is here scrutinized, in the context of the generalized uncertainty principle (GUP). Near-center and near-horizon Frobenius expansions of these solutions are studied. Their Hawking thermal spectrum is investigated out of the tunnelling method and the WKB procedure. Computing the Hawking flux of these black hole solutions shows that, for small black holes and for a precise combination of the GUP parameter and the parameters that govern the gravitational interaction in quadratic gravity, the black hole luminosity can vanish. This yields absolutely stable mini black hole remnants in quadratic gravity.
Marginally trapped surfaces in null normal foliation spacetimes: A one step generalization of LRS II spacetimes
Authors: Sherif Abbas , Goswami Rituparno , Maharaj Sunil D. 
Published: May 2020

In this paper, we study geometrical properties of marginally trapped surfaces in gravitational collapse, using a semi-tetrad covariant formalism, that provides a set of geometrical and matter variables. We first define a generalization (in a sense to be specified in the introduction) of LRS II spacetime — which we call NNF spacetimes — and show that the marginally trapped surfaces in NNF spacetimes (and the 3-surfaces they foliate) are topologically equivalently those of LRS II spacetimes. We then study the evolution of MTTs (3-surfaces foliated by marginally trapped surfaces), extending earlier work on LRS II spacetimes to NNF spacetimes, and in general any 4-dimensional spacetime. In addition, we perform a stability analysis for the marginally trapped surfaces in this formalism, using simple spacetimes as examples to demonstrate the applicability of our approach.
An annotated checklist of sea slug fauna of Gujarat coast, India
Authors: Vadher Piyush , Kardani Hitesh , Beleem Imtiyaz 
Published: May 2020

An annotated checklist of sea slugs from Gujarat coastal waters was prepared, based on published literature and field observations from 2014–2019. Ninety-five species from 62 genera belonging to 29 families were recorded. Species are listed with synonyms and distribution status.
Mission and Care for the Poor in Sydney Anglican Perspective
Authors: Williams David A. 
Published: May 2020

Abstract
Sydney Anglican theology has a number of distinctive motifs, including its ecclesiology and theology of the gospel. These motifs inform a theology of mission as proclamation that stands in a tradition that places a priority on evangelism. Where does such a missiological construction locate a theology of care for the poor? Answers to this question were explored through semi-structured interviews with faculty at Moore Theological College. The significance of caring for the poor is affirmed. Care for the poor is located in the life of the disciple of Jesus Christ and in the community life of the local church. The implications of this theological view for an understanding of the missio Dei are explored.