bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-wavelength fluorescence imaging with a da Vinci Firefly—a technical look behind the scenes
Authors: Meershoek Philippa , KleinJan Gijs H. , van Willigen Danny M. , Bauwens Kevin P. , Spa Silvia J. , van Beurden Florian , van Gennep Erik J. , Mottrie Alexandre M. , van der Poel Henk G. , Buckle T. , van Leeuwen Fijs W. B. , van Oosterom Matthias N. 
Published: November 2020

AbstractThe field of fluorescence-guided surgery builds on colored fluorescent tracers that have become available for different clinical applications. Combined use of complementary fluorescent emissions can allow visualization of different anatomical structures (e.g. tumor, lymphatics and nerves) in the same patient. With the aim to assess the requirements for multi-color fluorescence guidance under in vivo conditions, we thoroughly characterized two FDA-approved laparoscopic Firefly camera systems available on the da Vinci Si or da Vinci Xi surgical robot. In this process, we studied the cameras’ performance with respect to the photophysical properties of the FDA-approved dyes Fluorescein and ICG. Our findings indicate that multi-wavelength fluorescence imaging of Fluorescein and ICG is possible using clinical-grade fluorescence laparoscopes, but critical factors for success include the photophysical dye properties, imaging system performance and the amount of accumulated dye. When comparing the camera performance, the Xi system provided more effective excitation (adaptions in the light source) and higher detection sensitivity (chip-on-a-tip and/or enhanced image processing) for both Fluorescein and ICG. Both systems can readily be used for multi-wavelength fluorescence imaging of Fluorescein and ICG under clinically relevant conditions. With that, another step has been made towards the routine implementation of multi-wavelength image-guided surgery concepts.
A computed tomography algorithm for crossing coronary chronic total occlusions: riding on the wave of the proximal cap and distal vessel segment
Authors: Opolski M. P. , Nap A. , Knaapen P. 
Published: November 2020

AbstractWith wider adoption of coronary computed tomography angiography (coronary CTA), chronic total occlusions (CTOs) are being increasingly identified and characterised by non-invasive angiography. In particular, the ability of coronary CTA to clearly delineate atherosclerotic plaque, as well as to display three-dimensional vessel trajectories, has garnered particular attention in the context of preprocedural planning and periprocedural guidance of CTO percutaneous coronary intervention (PCI). Single CTO features and combined scoring systems derived from CTA (mostly exceeding the diagnostic performance of the angiographic J‑CTO score) have been used to predict time-efficient guidewire crossing, and thus grade the CTO difficulty level prior to PCI. In addition, the introduction of three-dimensional CTA/fluoroscopy co-registration for periprocedural navigation during CTO PCI offers the unprecedented opportunity to resolve proximal cap ambiguity and clearly visualise the distal CTO segment, thereby potentially influencing CTO PCI strategies and techniques. In this review, the potential advantages of non-invasive evaluation of CTO by coronary CTA are described, and a CTA-based hybrid algorithm is introduced for further enhancing the efficiency of CTO PCI. Further studies are clearly needed to verify the proposed approach. However, several luminary operators have already implemented coronary CTA for planning and periprocedural guidance of CTO interventions using the hybrid algorithm.
Nutrient profiles, functional compositions, and antioxidant activities of seven types of grain fermented with Sanghuangporus sanghuang fungus
Authors: Song Tingting , Zhang Zuofa , Jin Qunli , Feng Weilin , Shen Yingyue , Fan Lijun , Cai Weiming 
Published: November 2020

AbstractSanghuangporus sanghuang (SS) is a rare medicinal polypore fungus that grows solely on Morus trees. In this study, seven grains (oats, barley, millet, rice, buckwheat, corn, and coix seed) were used as solid substrates for SS fermentation and characterized in their nutrition, functional composition, and antioxidant activities. After fermentation, the nutrient compositions of crude protein (F1,41 = 111.1, P < 0.01), soluble protein (F1,41 = 595.7, P < 0.01), soluble sugar (F1,41 = 51.4, P < 0.01) and ash (F1,41 = 227.3, P < 0.01) increased significantly. Oats were one of the best grains for SS fermentation, SS-Oat produced 6.23 mg QE/g polyphenols, 21.8 mg rutin/g flavonoids, and 2.3% triterpene. In addition, the antioxidant capacities of the seven grains all increased. Principal component analysis analysis shows that the antioxidant properties of the grains were similar after SS fermentation. The changes of antioxidant activity due to SS fermentation were corrected with corresponding grain and remarked as ΔT-AOC/ABTS+/DPPH/DNAp, that was correlated to part of changes in polyphenol, carotenoid, triterpenoids, and flavonoid contents. In summary, oats have the greatest potential for use as a fermentation substrate for health food development.
Heavy metal index and geographical information system (GIS) approach to study heavy metal contamination: a case study of north Chennai groundwater
Authors: Mahapatra S. R. , Venugopal T. , Shanmugasundaram A. , Giridharan L. , Jayaprakash M. 
Published: November 2020

AbstractFifty-four groundwater samples were collected from the highly industrialized area of north Chennai. These groundwater samples were tested for Fe, Mn, Cu, Ni, Pb, Zn and Cr in pre-monsoon and post-monsoon periods of 2015–2016. Most of the samples in the area were found to have high concentration of heavy metals. Geographical information system was used to develop contour maps for the analysis of heavy metals, and it has been found that most of the Ambattur area was affected by the heavy metals in both the seasons. ANOVA tests were carried out on the hydro-chemical data for both the monsoon periods, and it was found that there was a common source of origin for most of the heavy metals, which was also confirmed by the correlation and principal component analysis. T-test indicates that there was a common source of origin of heavy metals in the study area, viz. industrial and domestic pollutants, that were found to be the main source of heavy metals in both the monsoon periods. Principal component analysis gave three important factors (principal components) for both the seasons. Pre-monsoon groundwater samples showed a common cause of origin of heavy metals than the post-monsoon samples. Heavy metal pollution index indicates that almost all the samples were not fit for drinking purpose in both the monsoon periods and metal index also indicates the non-usability of the water for drinking purpose.
Contralateral Effects of Unilateral Strength and Skill Training: Modified Delphi Consensus to Establish Key Aspects of Cross-Education
Authors: Manca A. , Hortobágyi T. , Carroll T. J. , Enoka R. M. , Farthing J. P. , Gandevia S. C. , Kidgell D. J. , Taylor J. L. , Deriu F. 
Published: November 2020

Abstract
Background
Cross-education refers to increased motor output (i.e., force generation, skill) of the opposite, untrained limb following a period of unilateral exercise training. Despite extensive research, several aspects of the transfer phenomenon remain controversial.

Methods
A modified two-round Delphi online survey was conducted among international experts to reach consensus on terminology, methodology, mechanisms of action, and translational potential of cross-education, and to provide a framework for future research.

Results
Through purposive sampling of the literature, we identified 56 noted experts in the field, of whom 32 completed the survey, and reached consensus (75% threshold) on 17 out of 27 items.

Conclusion
Our consensus-based recommendations for future studies are that (1) the term ‘cross-education’ should be adopted to refer to the transfer phenomenon, also specifying if transfer of strength or skill is meant; (2) functional magnetic resonance imaging, short-interval intracortical inhibition and interhemispheric inhibition appear to be promising tools to study the mechanisms of transfer; (3) strategies which maximize cross-education, such as high-intensity training, eccentric contractions, and mirror illusion, seem worth being included in the intervention plan; (4) study protocols should be designed to include at least 13–18 sessions or 4–6 weeks to produce functionally meaningful transfer of strength, and (5) cross-education could be considered as an adjuvant treatment particularly for unilateral orthopedic conditions and sports injuries. Additionally, a clear gap in views emerged between the research field and the purely clinical field.
The present consensus statement clarifies relevant aspects of cross-education including neurophysiological, neuroanatomical, and methodological characteristics of the transfer phenomenon, and provides guidance on how to improve the quality and usability of future cross-education studies.
An efficient three-dimensional foil structure model for bump-type gas foil bearings considering friction
Authors: Gu Yongpeng , Lan Xudong , Ren Gexue , Zhou Ming 
Published: November 2020

AbstractThis paper presents an efficient three-dimensional (3D) structural model for bump-type gas foil bearings (GFBs) developed by considering friction. The foil structures are modeled with a 3D shell finite element model. Using the bump foil mechanical characteristics, the Guyan reduction and component mode synthesis methods are adopted to improve computational efficiency while guaranteeing accurate static responses. A contact model that includes friction and separation behaviors is presented to model the interactions of the bump foil with the top foil and bearing sleeve. The proposed structural model was validated with published analytical and experimental results. The coupled elastohydrodynamics model of GFBs was established by integration of the proposed structural model with data on hydrodynamic films, and it was validated by comparisons with existing experimental results. The performance of a bearing with an angular misalignment was studied numerically, revealing that the reaction torques of the misaligned bearing predicted by GFB models with 2D and 3D foil structure models are quite different. The 3D foil structure model should be used to study GFB misalignment.
Enhanced micro/nano-tribological performance in partially crystallized 60NiTi film
Authors: He Wanjun , Zeng Qunfeng 
Published: November 2020

AbstractThe microstructure, mechanical and micro/nano-tribological properties of the 60NiTi film annealed at different temperature were investigated. The results reveal that annealing as-deposited 60NiTi film at 300, 375, and 600 °C for 1 h leads to structural relaxation, partial crystallization and full crystallization, respectively. Compared with the structurally relaxed structure, the partially crystallized structure exhibits increased hardness but decreased elastic modulus. This is because that the elastic modulus is reduced by Voigt model while the hardness is improved by composite effect. Due to the highest hardness and ratio of hardness to elastic modulus (H/E), the partially crystallized 60NiTi film has the lowest penetration depth and residual depth (i.e., groove depth). Besides, the results also reveal that ductile plowing is the dominant wear mechanism for all the annealed 60NiTi films. Under the condition of the ductile plowing, coefficient of friction and wear resistance are related to penetration depth and residual depth, respectively. Therefore, the partially crystallized 60NiTi film shows the best tribological performance at the micro/nano-scale. The current work not only highlights the important roles of hardness and H/E in improving the micro/nano-tribological properties but also concludes an efficient and simple method for simultaneously increasing hardness and H/E.
Familiäre gastrointestinale Tumorerkrankungen: daran denken!
Authors: Djanani Angela 
Published: November 2020

ZusammenfassungEine familiäre Tumorerkrankung hat nicht nur therapeutische Konsequenzen für die Patienten selbst, sondern ist auch für nahe Angehörige von großer Relevanz im Hinblick auf Früherkennung und Prävention. Deshalb sollte vor allem bei jungem Erkrankungsalter, auffälliger Familienanamnese und bestimmten klinischen und histologischen Erkrankungsmerkmalen daran gedacht und eine genetische Abklärung veranlasst werden.
Two factors, one direction towards social regulation policy convergence
Authors: Chhabra Gagan 
Published: November 2020

Two significantly different countries such as Norway and India have adopted similar social regulation policies aimed at the employment of disabled people since the 1990s. Countries can adopt social regulation policies, such as anti-discrimination provisions, owing to multiple factors. This article uncovers two common factors leading to policy convergence within social regulation reforms aimed at the employment of disabled people in Norway and India. An exploratory qualitative case study was conducted, wherein 25 policy experts (11 from Norway and 14 from India) were interviewed. Findings from expert interviews indicate that the observed policy convergence are connected to two trends that can be detected both in Norway and India. The first concerns the influence of international treaties; the second concerns grassroots mobilization of disabled people and their organizations. Findings point towards increasing internationalization of social regulation policies and these policy developments transcend the global North and global South divide.
Associations between dietary total antioxidant capacity and odds of non-alcoholic fatty liver disease (NAFLD) in adults: a case–control study
Authors: Sohouli Mohammad Hassan , Fatahi Somaye , Sayyari Aliakbar , Olang Beheshteh , Shidfar Farzad 
Published: November 2020

Abstract
The relationships between the total antioxidant capacity (TAC) of the diet and the risk of non-alcoholic fatty liver disease (NAFLD) have not previously been assessed. The aim of this study was to assess relationships between DTAC and odds of NAFLD in a case–control study. This case–control study was carried out in 158 patients with NAFLD and 357 healthy individuals aged 18–55 years. Dietary data were collected using validated 168-item quantitative food frequency questionnaires. Triacylglycerols (TAGs), total cholesterol (TC), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C) and fasting blood glucose (FBS) concentrations were assessed using enzymatic methods and commercial kits. The DTAC was calculated based on the oxygen radical absorbance capacity of each food reported by the U.S. Department of Agriculture. The mean ± sd (standard deviation) for age and body mass index (BMI) of the study participants were 43⋅9 years ±5⋅9 and had 30⋅5 kg/m2 ±2⋅6. The NAFLD patients included higher BMI and female proportion, compared with the control group. The NAFLD patients included higher smoking rates, biochemical parameters (TG, TC, LDL-C and FBS) and DTAC scores, compared with control groups (P-value < 0⋅05). However, patients with NAFLD had lower HDL levels and physical activities, compared with the control group. The highest tertile of DTAC showed lower odds of NAFLD, compared with the lowest tertile. This association was significant after adjustment for potential confounders (OR, 0⋅19; 95 % CI, 0⋅9–0⋅34; P for trend 0⋅001). Findings suggest that the promotion of naturally increased antioxidant capacities may help prevent odds of NAFLD.
Is ergothioneine a ‘longevity vitamin’ limited in the American diet?
Authors: Beelman Robert B. , Kalaras Michael D. , Phillips Allen T. , Richie John P. 
Published: November 2020

Abstract
There is mounting evidence for the potential for the natural dietary antioxidant and anti-inflammatory amino acid l-Ergothioneine (ERGO) to prevent or mitigate chronic diseases of aging. This has led to the suggestion that it could be considered a ‘longevity vitamin.’ ERGO is produced in nature only by certain fungi and a few other microbes. Mushrooms are, by far, the leading dietary source of ERGO, but it is found in small amounts throughout the food chain, most likely due to soil-borne fungi passing it on to plants. Because some common agricultural practices can disrupt beneficial fungus–plant root relationships, ERGO levels in foods grown under those conditions could be compromised. Thus, research is needed to further analyse the role agricultural practices play in the availability of ERGO in the human diet and its potential to improve our long-term health.
Food availability and advertising within food outlets around primary healthcare services in Brazil
Authors: Horta Paula M. , Souza Juliana de P. M. , Freitas Patrícia P. , Lopes Aline C. S. 
Published: November 2020

Abstract
The consumer food environment is changing: an extensive variety of foods are now available in most markets, offering palatability, convenience and novelty. However, little is known about the availability and advertising of food items within food outlets, especially among developing countries. The present study examined these dimensions in 281 food outlets located around eighteen primary healthcare services in Belo Horizonte, Brazil, in 2013. These establishments were classified as large-chain supermarkets; specialised fruits and vegetable (F&V) markets; and local grocery stores, convenience stores or bakeries. Availability of F&V, availability of ultra-processed foods (UPF) and food advertising were compared across the food outlet categories by applying the χ2 test. Almost 60 % of the food outlets were specialised F&V markets, 21⋅4 % were large-chain supermarkets and 19⋅2 % were local grocery stores, convenience stores or bakeries. Almost 80 % contained at least eight types of fruits and vegetables, and 60 % contained UPF. Food advertisement was absent in 59⋅8 % of the food outlets, 19⋅6 % were advertising only F&V and 17⋅4 % were advertising only UPF. Higher F&V availability was noted inside specialised F&V markets and large-chain supermarkets than local grocery stores, convenience stores or bakeries. Advertising of F&V was more common within specialised F&V markets. However, large-chain supermarkets and local grocery stores, convenience stores or bakeries contained more frequent UPF food advertising isolated: 38⋅3 and 35⋅2 %, respectively. Therefore, the availability and advertising of food items within food outlets around primary healthcare services are different according to the type of food outlet.
The Multiclass Classification of Newspaper Articles with Machine Learning: The Hybrid Binary Snowball Approach
Authors: Sebők Miklós , Kacsuk Zoltán 
Published: November 2020

AbstractIn this article, we present a machine learning-based solution for matching the performance of the gold standard of double-blind human coding when it comes to content analysis in comparative politics. We combine a quantitative text analysis approach with supervised learning and limited human resources in order to classify the front-page articles of a leading Hungarian daily newspaper based on their full text. Our goal was to assign items in our dataset to one of 21 policy topics based on the codebook of the Comparative Agendas Project. The classification of the imbalanced classes of topics was handled by a hybrid binary snowball workflow. This relies on limited human resources as well as supervised learning; it simplifies the multiclass problem to one of binary choice; and it is based on a snowball approach as we augment the training set with machine-classified observations after each successful round and also between corpora. Our results show that our approach provided better precision results (of over 80% for most topic codes) than what is customary for human coders and most computer-assisted coding projects. Nevertheless, this high precision came at the expense of a relatively low, below 60%, share of labeled articles.
A mycoprotein-based high-protein vegan diet supports equivalent daily myofibrillar protein synthesis rates compared with an isonitrogenous omnivorous diet in older adults: a randomised controlled trial
Authors: Monteyne Alistair J. , Dunlop Mandy V. , Machin David J. , Coelho Mariana O. C. , Pavis George F. , Porter Craig , Murton Andrew J. , Abdelrahman Doaa R. , Dirks Marlou L. , Stephens Francis B. , Wall Benjamin T. 
Published: November 2020

AbstractAnimal-derived dietary protein ingestion and physical activity stimulate myofibrillar protein synthesis rates in older adults. We determined whether a non-animal-derived diet can support daily myofibrillar protein synthesis rates to the same extent as an omnivorous diet. Nineteen healthy older adults (aged 66 (sem 1) years; BMI 24 (sem 1) kg/m2; twelve males, seven females) participated in a randomised, parallel-group, controlled trial during which they consumed a 3-d isoenergetic high-protein (1·8 g/kg body mass per d) diet, where the protein was provided from predominantly (71 %) animal (OMNI; n 9; six males, three females) or exclusively vegan (VEG; n 10; six males, four females; mycoprotein providing 57 % of daily protein intake) sources. During the dietary control period, participants conducted a daily bout of unilateral resistance-type leg extension exercise. Before the dietary control period, participants ingested 400 ml of deuterated water, with 50-ml doses consumed daily thereafter. Saliva samples were collected throughout to determine body water 2H enrichments, and muscle samples were collected from rested and exercised muscle to determine daily myofibrillar protein synthesis rates. Deuterated water dosing resulted in body water 2H enrichments of approximately 0·78 (sem 0·03) %. Daily myofibrillar protein synthesis rates were 13 (sem 8) (P = 0·169) and 12 (sem 4) % (P = 0·016) greater in the exercised compared with rested leg (1·59 (sem 0·12) v. 1·77 (sem 0·12) and 1·76 (sem 0·14) v. 1·93 (sem 0·12) %/d) in OMNI and VEG groups, respectively. Daily myofibrillar protein synthesis rates did not differ between OMNI and VEG in either rested or exercised muscle (P > 0·05). Over the course of a 3-d intervention, omnivorous- or vegan-derived dietary protein sources can support equivalent rested and exercised daily myofibrillar protein synthesis rates in healthy older adults consuming a high-protein diet.
Changes in the chemical and in-vitro antihypertensive properties of sweet whey obtained from miniature fresh, Chanco and Gouda-style model cheeses
Authors: Godoy Josemaría , Peslerbes Marie , Vyhmeister Stefanie , Vargas-Bello-Pérez Einar , Fellenberg María Angélica , Ibáñez Rodrigo A. 
Published: November 2020

AbstractThis Technical Research Communication evaluated the influence of various cheese manufacture methods on the composition and in vitro antihypertensive activity of sweet whey samples obtained from miniature models for fresh, Chanco and Gouda-style cheese processing using bulk-tank milks throughout a year. Raw milks from morning milking were standardized, pasteurized and used to obtain sweet whey using cheesemaking protocols for each variety on 200 g scale, as well the use of whey dilution at levels of 0, 15, 30 and 45% in Chanco and Gouda-style making. The composition of sweet whey obtained within each cheesemaking variety was similar among different timepoints of the year (P > 0.05), which was attributed to similar composition of milks and the use standardized cheesemaking protocols used for this study. As expected, the use of whey dilution led to sweet whey samples with reduced levels of total solids (P < 0.05), but they exhibited an improvement of the in vitro antihypertensive properties, which may be attributed to the formation of low-molecular weight bioactive peptides due to increased cheese making times. The results of this study suggest that modifying cheese manufacture protocols may have a direct impact on the bioactive properties of sweet whey. Future work will be required to identify and evaluate the feasibility to purify bioactive peptides obtained from sweet whey.