bluuebunny/crossref_metadata_2025_split huggingface dataset:
Covering Small Subgraphs of (Hyper)Tournaments with Spanning Acyclic Subgraphs
Authors: Yuster Raphael 
Published: October 2020

While the edges of every tournament can be covered with two spanning acyclic subgraphs, this is not so if we set out to cover all acyclic $H$-subgraphs of a tournament with spanning acyclic subgraphs, even for very simple $H$ such as the $2$-edge directed path or the $2$-edge out-star. We prove new bounds for the minimum number of elements in such coverings and for some $H$ our bounds determine the exact order of magnitude.
A $k$-tournament is an orientation of the complete $k$-graph, where each $k$-set is given a total order (so tournaments are $2$-tournaments). As opposed to tournaments, already covering the edges of a $3$-tournament with the minimum number of spanning acyclic subhypergraphs is a nontrivial problem. We prove a new lower bound for this problem which asymptotically matches the known lower bound of covering all ordered triples of a set.
Factors governing the affinity and selectivity of histone deacetylase inhibitors for the HDAC8 enzyme active site: Implications for anticancer therapy
Authors: Toshev Nikolay , Cheshmedzhieva Diana , Dudev Todor 
Published: October 2020

Disruptions in post-translational modifications of chromatin structure promote uncontrollable cell growth branded as a hallmark of tumor lesions. The overexpression/hyperactivity of histone deacetylases (HDACs) is a common feature for the tumorogenesis and cancer progression. Several inhibitors of histone deacetylases (mainly hydroxamic acid derivatives) have been successfully used as drugs in fighting tumor formations. However, there is no systematic study on the factors controling the affinity and selectivity of this type of inhibitors to the host enzyme thus hampering successful rational design of more potent and selective anticancer drugs. Herein, in an attempt to illuminate the mechanism of the host – guest interactions in these systems at atomic level we systematically study the effect of various factors in the process and unravel its key determinants. Density functional theory calculations have been employed. Our findings have the potential to be employed as guidelines in designing new HDAC inhibitors with improved anticancer properties.
Meninjau Kembali Standar Pendidik dan Tenaga Kependidikan dalam Meningkatkan Mutu Pendidikan
Authors: Nur Salim  
Published: October 2020

Untuk menciptakan SDM yang berkualitas tentu dengan melalui pendidikan yang baik dan berkualitas pula. Bila pendidikan tidak berkualitas, karena menerapkan pola yang salah, maka hanya akan menghasilkan SDM kelas teri yang bermental kuli dan bermartabat rendah. Pendidik merupakan ujung tombak keberhasilan pendidikan, sehingga dituntut untuk memenuhi, kualifikasi akademik dan kompetensi sebagai agen pembelajaran, sehat jasmani dan rohani. Disamping tenaga pendidik, tenaga kependidikan juga mempunyai peran yang utama dalam mewujudkan pendidikan yang berkualitas. Peran utama tenaga kependidikan adalah memberikan pelayanan teknis untuk menunjang pendidikan pada satauan pendidikan.
La catégorisation, entre cognition et interaction
Authors: Zogmal Marianne , Filliettaz Laurent 
Published: October 2020

L’ambition de cette conclusion est de revenir sur quelques-uns des présupposés théoriques que véhiculent les textes présentés dans le cadre de ce volume, et de les faire dialoguer avec un point de vue alternatif, celui de l’analyse de l’interaction. En dépit des éléments de variation, voire de controverses qui les caractérisent, les articles convergent, à certains égards, sur la manière de conceptualiser la problématique de la catégorisation comme un phénomène de nature cognitive. Ils prennent également position, de manière plus ou moins explicite, sur la manière dont ces phénomènes cognitifs s’articulent à la problématique de l’action, de la temporalité et du langage, notamment. Après avoir dégagé ces éléments transversaux de positionnement qui permettent de « catégoriser » les textes produits, nous proposons de considérer la problématique des catégories dans les conditions de leur mise en œuvre dans les interactions verbales et non verbales. Un déplacement du regard est ici proposé, qui amène à renverser, ou du moins à mettre en perspective les présupposés d’une approche cognitive de la catégorisation. Afin d’illustrer notre propos, nous terminons cet article en présentant quelques données empiriques portant sur la conduite d’une activité ludique dans le champ de l’éducation de la petite enfance. Nous y montrons que des processus de catégorisation y sont à l’œuvre en permanence, et qu’ils constituent une condition de la conduite de l’activité, dès lors que celle-ci est conçue comme un processus dynamique et situé de coordination entre les participants.
Que recouvre la fonction d’enseignant référent ? Cartographie d’une activité
Authors: Laville Matthieu 
Published: October 2020

Depuis la rentrée scolaire 2006, les enseignants référents ont la charge d’accompagner les parcours de scolarisation des élèves handicapés, en coordonnant les actions entre les différents partenaires par le biais d’Équipes de suivi de scolarisation (ESS). S’appuyant sur la sociologie des groupes professionnels, cet article vise à étudier l’activité concrète qui se cache derrière l’appellation générique d’enseignant référent. Il propose d’apprécier cette activité à l’aune des prescriptions encadrant cette fonction. L’article expose alors les étapes qui ont balisé le passage graduel d’une ethnographie exploratoire à la construction d’un questionnaire à portée nationale. Les résultats mettent en évidence des traductions parfois différentes des prescriptions et aboutissent à une cartographie des principaux pans de l’activité. Ils permettent enfin de saisir les déterminants qui influencent le plus la fréquence des programmations d’ESS.
Comment analyser ce que font les enseignants dans la préparation de leurs cours ? Ébauche d’un cadre conceptuel
Authors: Maitre Jean-Philippe , Huchette Michaël , Bruillard Éric 
Published: October 2020

En préparant leurs cours, les enseignants fabriquent des supports pour leurs élèves, et mobilisent pour cela des ressources qui leur sont propres et d’autres qu’ils trouvent sur internet, auprès de collègues, etc. Cette activité ordinaire s’avère complexe et faiblement documentée par la recherche. De quoi les enseignants partent-ils pour préparer leurs cours ? Comment s’y prennent-ils pour en faire des supports d’enseignement ? Comment les supports de cours sont-ils recyclés d’une année sur l’autre ? Cet article propose quelques repères théoriques pour l’analyse de ces questions. Le propos s’inscrit dans le cadre du projet ANR ReVEA, présenté succinctement. Il est étayé par la littérature de recherche – rare sur le sujet – et par des données d’enquête par entretien auprès d’enseignants français de technologie au collège et de sciences et technologies de l’ingénieur au lycée. La conclusion pose la question du caractère systémique de l’organisation de cette part du travail enseignant, ouvrant de nouvelles perspectives de recherche.
Clinical Engagement with Finance: Now more than ever!
Authors: Naik Kshiteeja , Maheswaran Akeeban 
Published: October 2020

The COVID-19 pandemic has affected all aspects of healthcare. The NHS has had to manoeuvre faster than ever before, which is remarkable for a huge organisation known to advance slowly and steadily. The adaptations have had both positive and negative impacts. There were also funding changes, in the form of temporary contractual arrangements. As the NHS plans for the future, an opportunity has arisen to fundamentally change the NHS funding structure.
This article will describe the effect of COVID-19 on healthcare finance, the challenges in developing a new payment structure, and the role that clinicians can play in helping shape funding arrangements in the future.
Efficacy of intra-articular autologous platelet rich plasma injection in primary knee osteoarthritis; a quasi-experimental study
Authors: Uzma Akhlaque  , Saeed Bin Ayaz  , Noreen Akhtar  
Published: October 2020

Abstract
Objectives: To observe the efficacy of platelet rich plasma on pain improvement in knee osteoarthritis patients, and to explore the impact of various facotrs on pain reduction with such a treatment.
Method: The quasi-experimental study was conducted at the Armed Forces Institute of Rehabilitation Medicine, Rawalpindi, Pakistan, from October 2017 to April 2018, and comprised patients with primary knee osteoarthritis. The sample was sub-grouped into “normal”, “overweight” and “obese” on the basis of body mass index. Two age-based sub-groups were also formed at ?60 years and >60 years. Three injections of calcium gluconate activated 2.5ml platelet rich plasma were given in the knees at an interval of two weeks each. The pain score was calculated using the numerical rating scale at the 6th week. Data was analysed using SPSS 20.
Results: Of the 50 patients, 26(52%) were females and 24(48%) were males. The overall mean age was 59.6±9.6 years (range: 42-75 years), with 22(44%) aged ? 60 years. There were 21(42%) patients who were overweight, 7(14%) had normal weight and 22(44%) were obese. There was significant pain reduction post-treatment compared to the baseline (p<0.001). The reduction in pain was not significantly related to gender, age, knee osteoarthritis grade, or body mass index (p>0.05).
Conclusions: Platelet rich plasma significantly improved pain in knee osteoarthritis patients regradless of all age, gender, grade and body mass index.
Key Words: Intra-articular injections, Primary knee osteoarthritis, Platelet rich plasma, Efficacy.
Continuous...
Post-traumatic stress disorder, cognitive function and adjustment problems in women burn survivors: a multicenter study
Authors: Zaqia Bano  , Iram Naz  
Published: October 2020

Abstract
Objective: To investigate the relationship of post-traumatic stress disorder, cognitive function and adjustment problems in women burn survivors.
Methods: The analytical cross-sectional study was conducted at the Department of Psychology, University of Gujrat, Pakistan, from November 15, 2017, to July 25, 2018, and comprised women burn survivors at different burn centres of hospitals, household bases and non-governmental organisations of Lahore, Gujrat, Rawalpindi and Islamabad, Pakistan. Data was collected using the civilian version of the standardised Post-Traumatic Stress Disorder Checklist, the Montreal Cognitive Assessment and the Adjustment Problem Scale for Adults. Data was analysed using Analysis of a Moment Structures software version 21.
Results: Of the 200 women, 100(50%) each were living in nuclear and joint family systems. The maximum number of women 74(37%) were aged 15-25 years; 93(46.5%) were married; and 82(41%) were employed. Post-traumatic stress disorder affected cognitive issues and adjustment of women burn survivors (p=0.000).
Conclusion: Post-traumatic stress disorder significantly affected cognitive issues and adjustment problems of women burn survivors.
Key Words: Post-traumatic stress disorder, Cognitive, Women burn survivors, Burn centres, Cross-sectional study, Multivariate Analysis.
Continuous...
ESTADO DE ALARMA Y COVID-19: EL RÉGIMEN ADMINISTRATIVO SANCIONADOR EN LA COMUNIDAD AUTÓNOMA DE EUSKADI
Authors: ANGULO GARZARO AMAYA , ANGULO GARZARO NOEMI , TEJERO YUSTOS JOSE IGNACIO 
Published: October 2020

En un escenario marcado por la elevación a pandemia de la situación de emergencia de salud pública ocasionada por el COVID-19, el Estado español decidió declarar el estado de alarma. De modo preliminar vamos a estudiar si el estado de alarma es el nivel de excepcionalidad adecuado, a la luz de la configuración por la que ha optado el sistema español ¿diferenciadora, en lugar de gradualista¿.
A continuación, haremos específica referencia a los ilícitos de naturaleza administrativa en que se puede incurrir al vulnerar la limitación de circulación impuesta. Así, pretendemos analizar cuál es la normativa sectorial más adecuada para encuadrar el reproche punitivo, y cuál es la autoridad competente para la incoación, tramitación y resolución del expediente.
Por último, haremos una breve referencia a la incidencia que tiene la suspensión de términos e interrupción de plazos sobre la tramitación del expediente administrativo sancionador correspondiente.
COVID-19k eragindako osasun publikoko larrialdi-egoera pandemiara igotzeak markatutako egoera batean, Espainiako Estatuak alarma-egoera deklaratzea erabaki zuen. Lehenik eta behin, alarma-egoera salbuespen-maila egokia den aztertuko dugu, Espainiako sistemak hautatu duen konfigurazioaren arabera ¿bereizlea, gradualista izan beharrean¿.
Jarraian aipatzen den osasun publikoko larrialdi-egoera pandemiara igotzearen ondorioz, berariaz aipatuko ditugu ezarritako zirkulazio-muga urratzean gerta daitezkeen administrazio-arloko arau-hausteak. Horrela, aztertu nahi dugu zein den zigor-gaitzespena kokatzeko araudi sektorial egokiena, eta zein den espedientea hasteko, izapidetzeko eta ebazteko agintaritza eskuduna.
Azkenik, labur-labur aipatuko dugu terminoak eteteak eta epeak geldiarazteak zer eragin duen dagokion zehapen-espediente administratiboaren izapidetzean.
In a scenario where the public health emergency situation caused by COVID-19 was considered to be pandemic, Spain decided to declare a state of alarm. First, we are going to study whether the state of alarm is the appropriate level of exceptionality, in the light of the configuration adopted by the Spanish system ¿ a differentiating, rather than staggered one.
Next, we will make specific reference to the illicit acts of an administrative nature that may occur by violating the movement limitation imposed. Thus, we intend to analyze which the most appropriate sector-specific regulation to frame the punitive reproach and who the competent authority for the initiation, processing and resolution of the file should be.
Lastly, we will make a brief reference to the impact of the suspension of terms and the interruption of limitation periods regarding the corresponding sanctioning administrative proceedings.
Synthetic weather diaries: concept and application to Swiss weather in 1816
Authors: Brönnimann Stefan 
Published: October 2020

Abstract. Climate science is about to produce numerical daily weather reconstructions based on meteorological measurements for central Europe 250 years back. Using a pilot reconstruction covering Switzerland at a 2×2 km2 resolution for 1816, this paper presents methods to translate numerical reconstructions and derived indices into text describing daily weather and the state of vegetation. This facilitates comparison with historical sources and analyses of the effects of weather on different aspects of life. The translation, termed “synthetic weather diary”, could possibly be used to train machine learning approaches to do the reverse: reconstruct past weather from categorised text entries in diaries.
Kronik
Authors: Philipson Lotte 
Published: October 2020

Indhold: Udstillingen "På given foranledning..."; Bjørn Bursel i Fiolstræde; Forhallens ottekantede montre; Nye bøger; Enestående Søren Kierkegaard-manuskript overdraget til Det kongelige Bibliotek; Erhvervelser; Udlån til udstillinger; Besøg; Det kongelige Bibliotek i Forum, Bog Forum; Frimærkehandler og jernbanehistoriker Peer Olav Thomassens Fond; Personalia
Kronik & Publikationer
Authors: Philipson Lotte 
Published: October 2020

Indhold: Publikationer; Erhvervelser; Bogforum; Kulturnat; Musikalsk bryllupsgave til Kronprinsparret; Musik; Foredrag; Udstillinger; Det Kongelige Bibliotek på webben; Nyt revolutionerende søgesystem; Primo; Bøger og bibliotek
Kronik og publikationer
Authors: Philipson Lotte 
Published: October 2020

Indhold: Bøger og bibliotek; Ny bog om Småtrykssamlingen i Det Kongelige Bibliotek; H.O. Lange-Prisen for stor H.C. Ørsted-biografi; H.C. Andersens livsrejse med vennerne; Det Kongelige Bibliotek på nettet; Danske bøger op til 1600 nu på nettet; Luftfoto over Danmark 1944; Udstillinger; Foredrag; International forfatterscene; Bret Easton Ellis; Philip Pullman; A.S. Byatt; Fay Weldon; Herta Müller; Kulturnat i Den Sorte Diaman; Slaget ved Als og Dybbøl; Forfatteren Tom Buk-Swienty; Musik; Erhvervelser; Kongeligt biblioteksbord hos Royal Copenhagen; Publikationer
Søren Kierkegaard - den nye udgave
Authors: Nicolaisen Ida 
Published: October 2020

I februar 2013 afsluttedes den hidtil største – og eneste – samlede, kommenterede udgave af Søren Kierkegaards (1813-1855) trykte og utrykte skrifter, journaler, notesbøger og løse papirer samt breve og dedikationer efter 18 års arbejde i det til formålet af Danmarks Grundforskningsfond i 1994 oprettede Søren Kierkegaard Forskningscenter (SKC), ledet af direktør og dr.theol. Niels Jørgen Cappelørn, der i 2010 blev kaldet til et professorat i Kierkegaard-studier samtidig med, at Forskningscenteret blev indlejret i Det Teologiske Fakultet under Københavns Universitet. I 1999 oprettedes Fonden for Søren Kierkegaard Forskningscenteret, der har været forestået af en bestyrelse,1 udpeget af Grundforskningsfonden, hvori dekanen for Københavns Universitets Teologiske Fakultet og direktørerne for Det Kongelige Bibliotek og Det Danske Sprog- og Litteraturselskab har været udpeget. På Søren Kierkegaards 200 års fødselsdag d. 5. maj afsluttedes Fondens virke med en overdragelse af den trykte udgave af Søren Kierkegaards Skrifter (kaldet SKS-B), der i 55 bind udkom på Gads Forlag 1997-2013, og rettighederne til den til Københavns Universitet og af den elektroniske (kaldet SKS-E), se <sks. dk>, til Det Kongelige Bibliotek. Ved overrækkelsen i Universitetets festsal holdt bestyrelsens formand Ida Nicolaisen nedenstående overrækkelsestale, der skildrer arbejdet i historisk og nutidigt perspektiv.
Kronik
Authors: Philipson Lotte 
Published: October 2020

Indhold: Ukendte Italica; Udstilling på Det kongelige Bibliotek Amager 11. febr. - 4. marts 1994; Typer & Tegn. Et udvalg af Austin Grandjeans grafiske arbejder gennem 40 år; Udstilling på Det kongelige Bibliotek Slotsholmen 29. marts - 7. maj 1994; Den ottekantede montre; Udlån til udstillinger; Eksil i Danmark!; Besøg; Erhvervelser; Personalia;
Transiting to International Financial Reporting Standards for Small and Medium Sized Enterprises in Ethiopia: Benefits and Costs
Authors: Hunde Dagnachew Abera , Bayu Kefiyalew Belachew 
Published: October 2020

In every nation in the world small and medium enterprises (SME) have a crucial role in the Socio-economic development. Thus Over a decade’s they are increasingly attracting different stakeholder’s attention. It is in this regard the International Accounting standard Board (IASB) issued IFRS for SMEs in July 09, 2009. This study examined the Benefits and Costs of transiting to International financial reporting standard for Small and Medium sized Enterprises (IFRS for SMEs) in Ethiopia. So as to achieve this objective the researcher used mixed research approach. Semi-structured interview and questionnaires were used as an important tool for gathering the necessary data from tour operators as target group. From 320 SMEs given population size, 32 SMEs firms selected using systematic sampling technique and 93 is the sample size of respondents chosen from 32 SME firms based on Judgmental sampling technique.
It was found in this study the benefit of transition towards IFRS for SME is expected to decreases the information asymmetry between insiders and outsiders users of accounting information. Moreover its long run effect helps to achieve of the theoretical concept of the primary & secondary qualitative characteristics of accounting information (Relevance & Reliability Vs Comparability & understandability). Above all, the aggregate effects may increase the number of cross boarder investments, increasing the alternative of sources of financing and reducing cost of debt.
Furthermore, the finding shows transition towards IFRS for SME is costly to firms primarily because of the superior exertion of efforts, understanding and information systems needed and during post transition period additional effort needed to manage the risk of potential material misstatements appearing in the IFRS for SMEs-generated financial statements. Lack of knowledge (understanding) requires them to be engaged in a capacity building program with the coordination of Auditing and Accounting Board of Ethiopian & academicians.
Role of homocysteine in the development and progression of Parkinson’s disease
Authors: Fan Xiaoyan , Zhang Lixia , Li Haijun , Chen Guang , Qi Gangqiao , Ma Xueqiang , Jin Yuelei 
Published: October 2020

AbstractHomocysteine is an essential intermediate product of biochemical reactions that is present in various tissues of the human body. Homocysteine may be associated with the development and progression of Parkinson’s disease. Plasma homocysteine levels in patients with Parkinson’s disease are elevated compared to those of healthy individuals. High homocysteine drives PD development and progression while aggregating the clinical symptoms of PD patients. The relationship between PD and homocysteine involves multiple pathways, including nerve cell apoptosis, oxidative stress, and DNA damage. This is crucial for explaining how high homocysteine drives the PD procession. Elevated homocysteine level during PD development and progression offers a new strategy for the diagnosis and treatment of this disease.
In Vitro Model of Human Skeletal Muscle Tissues with Contractility Fabricated by Immortalized Human Myogenic Cells
Authors: Nagashima Takunori , Hadiwidjaja Stacy , Ohsumi Saki , Murata Akari , Hisada Takumi , Kato Ryuji , Okada Yohei , Honda Hiroyuki , Shimizu Kazunori 
Published: October 2020

AbstractIn the development process for drugs used to treat skeletal muscle, cell‐based contractile force assays have been considered as a useful in vitro test. Immortalized human myogenic cells are promising as cell sources for reproducible and well‐characterized in vitro models. In this study, it is investigated whether immortalized human myogenic cells, Hu5/KD3, have suitable contractile ability and the potential to be used as cell sources for contractile force assays. Muscle tissues are fabricated using Hu5/KD3 cells on the microfabricated devices used to measure contractile force. The tissues generate a tetanic force of ≈30 µN in response to the electrical pulse stimulation (EPS). Gene expression analysis of the myosin heavy chain (MYH) isoform indicates that the tissues mostly consisted of muscle fibers expressing MYH7 or/and MYH8. The addition of dexamethasone or lovastatin decreases the contractile force of the tissues, indicating that the tissues have the potential to evaluate drug candidates designed to treat muscle atrophy or statin‐induced myopathy. It is also demonstrated that the contractile force of tissues increased when EPS is applied as an artificial exercise. These results indicate that the Hu5/KD3 tissues can be employed for contractile force assays and would be useful for in vitro human skeletal muscle models.