bluuebunny/crossref_metadata_2025_split huggingface dataset:
Turkish inappropriate medication use in the elderly (TIME) criteria to improve prescribing in older adults: TIME-to-STOP/TIME-to-START
Authors: Bahat Gulistan , Ilhan Birkan , Erdogan Tugba , Halil Meltem , Savas Sumru , Ulger Zekeriya , Akyuz Filiz , Bilge Ahmet Kaya , Cakir Sibel , Demirkan Kutay , Erelel Mustafa , Guler Kerim , Hanagasi Hasmet , Izgi Belgin , Kadioglu Ates , Karan Ayse , Kulaksizoglu Isin Baral , Mert Ali , Ozturk Savas , Satman Ilhan , Sever Mehmet Sukru , Tukek Tufan , Uresin Yagiz , Yalcin Onay , Yesilot Nilufer , Oren Meryem Merve , Karan Mehmet Akif 
Published: March 2020

Abstract
Purpose
To improve prescribing in older adults, criterion sets have been introduced from different countries. While current criterion sets are useful to some extent, they do not meet the need in some European countries. Turkish inappropriate medication use in the elderly (TIME) criteria was planned to meet this need.

Methods
In phase 1, the user friendly sets: STOPP/START version2 and CRIME criteria were combined. National experts composed of geriatricians and non-geriatricians were invited to review and comment. In phase 2, thorough literature review was performed and reference-based revisions, omissions, and additions were made. Explanatory additions were added to some criteria to improve application in practice. In phase 3, all working group members reviewed the criteria/explanations and agreed on the final content.

Results
Phase 1 was performed by 49 expert academicians between May and October 2016. Phase 2 was performed by 23 working group academicians between October 2016 and November 2018 and included face-to-face interviews between at least two geriatrician members and one criterion-related specialist. Phase 3 was completed between November 2018–March 2019 with review and approval of all criteria by working group academicians. As a result, 55 criteria were added, 17 criteria were removed, and 60 criteria were modified from the first draft. A total of 153 TIME criteria composed of 112 TIME-to-STOP and 41 TIME-to-START criteria were introduced.

Conclusion
TIME criteria is an update screening tool that differs from the current useful tools by the interactive study of experts from geriatrics and non-geriatrics, inclusion of practical explanations for some criteria and by its eastern European origin. TIME study respectfully acknowledges its roots from STOPP/START and CRIME criteria. Studies are needed whether it would lead improvements in older adults’ health.
Sexual Behavior, Desire, and Psychosexual Experience in Gynephilic and Androphilic Trans Women: A Cross-Sectional Multicenter Study
Authors: Laube Jelena S. , Auer Matthias K. , Biedermann Sarah V. , Schröder Johanna , Hildebrandt Thomas , Nieder Timo O. , Briken Peer , Fuss Johannes 
Published: March 2020

Abstract

Background
One of the most prominent etiological theories of gender incongruence in trans women proposes a paraphilic erotic target location error (ie, autogynephilia) as a causal factor in gynephilic (ie, exclusively gynephilic and bisexual) trans women. We hypothesized that a paraphilic erotic target location should manifest itself in various aspects of sexual behavior, solitary and dyadic sexual desire, and psychosexual experience.

Aim
To compare sexual behavior, sexual desire, and psychosexual experience of exclusively gynephilic and bisexual trans women with that of androphilic trans women to explore whether their sexuality differs substantially.

Methods
Trans women diagnosed with gender dysphoria (Diagnostic and Statistical Manual of Mental Disorders–5) were recruited at 4 transgender healthcare centers in Germany. The present study analyzed items on sexual behavior, desire, and experience of a self-report questionnaire, collected as part of a cross-sectional multicenter study.

Main Outcomes
Multiple aspects of sexuality were examined using self-constructed items. Sexual desire was measured using the Sexual Desire Inventory and psychosexual experience using the Multidimensional Sexuality Questionnaire.

Results
Significantly more exclusively gynephilic than androphilic trans women reported a history of sexual arousal in relation to cross-dressing. However, little evidence was found that gynephilic and androphilic sexual desire, behavior, and psychosexual experience differ profoundly. Interestingly, a statistically non-significant trend indicated that gynephilic trans women who had not yet undergone gender affirming surgery showed the highest levels of sexual desire (solitary and dyadic), whereas the opposite was the case for androphilic trans women.

Clinical Translation
Data of this study indicate that sexual orientation does not appear to be a good predicator for sexual behavior, desire, and psychosexual experience in trans women.

Strengths and Limitations
We investigated sexual desire and experience using standardized and evaluated measures such as the Sexual Desire Inventory and Multidimensional Sexuality Questionnaire. Future studies with a larger sample size should investigate how different gender affirming medical intervention might have diverging influences on sexual behavior, desire, and experience.

Conclusion
Ultimately, this study found little evidence for the hypothesis that sexual behavior, sexual desire, and psychosexual experience differ substantially in gynephilic (exclusively gynephilic and bisexual) and androphilic trans women.
Crassostrea virginica dredge efficiency in Texas estuaries
Authors: Beseres Pollack Jennifer , Palmer Terence A. 
Published: March 2020

AbstractQuantifying and comparing stocks of oysters (Crassostrea virginica) within and among estuaries across the Gulf of Mexico is difficult because the sampling equipment used is either inconsistent among studies, or inefficient. In Texas, USA, stock assessments of oyster populations are made using an oyster dredge, which is an inefficient sampling tool. We compared sampling densities estimated by oyster dredges with more accurate estimates taken by diver-quadrat samples to determine a dredge efficiency rate. Our calculated efficiency rate (0.125) was negatively affected by the number of dead oysters, and the number and volume of total oysters in an area, but not affected by sediment grain size, water quality, and other oyster metrics. The dredge efficiency rate calculated in this study can be applied to past and future dredge-collected oyster quantity data to provide more realistic estimates of oyster densities and allow more accurate stock assessments and comparisons among studies and regions.
New tools for the visualization of glial fibrillary acidic protein in living cells
Authors: Letra-Vilela Ricardo , Quiteres Ricardo , Murtinheira Fernanda , Crevenna Alvaro , Hensel Zach , Herrera Federico 
Published: March 2020

AbstractThe glial fibrillary acidic protein (GFAP) is an intermediate filament widely used to identify and label astroglial cells, a very abundant and relevant glial cell type in the central nervous system. A major hurdle in studying its behavior and function arises from the fact that GFAP does not tolerate well the addition of protein tags to its termini. Here, we tagged human GFAP (hGFAP) with an enhanced green fluorescent protein (EGFP) for the first time, and substituted a previously reported EGFP tag on mouse GFAP (mGFAP) by a more versatile Halo Tag. Both versions of tagged GFAP were able to incorporate into the normal GFAP filamentous network in glioma cells, and Alexander disease-related mutations or pharmacological disruption of microtubules and actin filaments interfered with GFAP dynamics. These new tools could provide new fruitful venues for the study of GFAP oligomerization, aggregation and dynamics in living cells.
Microstructural Investigation of Plasma Sprayed Ceramic Coatings Using Peridynamics
Authors: Guski V. , Verestek W. , Oterkus E. , Schmauder S. 
Published: March 2020

ABSTRACTThe present study deploys a continuum mechanics approach called peridynamics to investigate the damage behaviour of a 2D microstructure, which was taken from a plasma sprayed ceramic coating used in solid oxide fuel cell (SOFC) sealing systems. At the beginning, two benchmark cases, namely, plate with a hole as well as plate with a single edge notch, are considered. The results are compared to an analytical solution and a very good agreement is obtained. Based on these findings, a microstructural model from a plasma sprayed ceramic coating of SOFC sealing systems is investigated. These micromechanical simulations show that structural defects influence the crack initiation as well as the crack propagation during interconnecting the defects. Typical crack mechanisms, such as crack deflection, crack shielding or multiple cracking, are observed. Additionally, an anisotropy of the effective mechanical properties is observed in this heterogeneous material, which is well known for plasma sprayed materials.
Efficacy of a sleep health intervention to optimize standard smoking cessation treatment response: results from a pilot randomized controlled trial
Authors: Patterson Freda , Grandner Michael A. , Malone Susan K. , Pohlig Ryan T. , Ashare Rebecca L. , Edwards David G. 
Published: March 2020

AbstractBackgroundWe tested if an adjunctive sleep health (SH) intervention improved smoking cessation treatment response by increasing quit rates. We also examined if baseline sleep, and improvements in sleep in the first weeks of quitting, were associated with quitting at the end of treatment.MethodsTreatment-seeking smokers (N = 29) aged 21–65 years were randomized to a SH intervention (n = 16), or general health (GH) control (n = 13) condition. Participants received six counseling sessions across 15-weeks: SH received smoking cessation + SH counseling; GH received smoking cessation + GH counseling. Counseling began 4-weeks before the target quit date (TQD), and varenicline treatment began 1-week prior to TQD. Smoking status and SH were assessed at baseline (week 1), TQD (week 4), 3 weeks after cessation (week 7), week 12, and at the end of treatment (EOT; week 15).ResultsSH versus GH participants had higher Carbon Monoxide (CO) -verified, 7-day point prevalence abstinence at EOT (69% vs. 54%, respectively; adjusted odds ratio (aOR) = 2.10, 95% confidence interval (CI) = 0.40–10.69, P = 0.77). Higher baseline sleep efficiency (aOR = 1.42, 95% CI = 1.03–1.96, P = 0.03), predicted higher EOT cessation. Models were adjusted for age, sex, education, and baseline nicotine dependence.ConclusionsImproving SH in treatment-seeking smokers prior to cessation warrants further examination as a viable strategy to promote cessation.
Stirrings of Revolt: Regressive Levies, the Pocketbook Squeeze, and the 1960s Roots of the 1970s Tax Revolt
Authors: MOUND JOSH 
Published: March 2020

Abstract:In most accounts, the modern American “tax revolt” begins with Proposition 13, passed by California voters in June 1978. In this telling, the revolt represents an antigovernment, antiliberal shift among white homeowners instrumental in the “rise of the right” and the fall of the “New Deal order” that culminated in Ronald Reagan’s election in 1980 and his subsequent tax cuts. This article challenges that account by demonstrating that the revolt began more than a decade before Prop 13 as approval rates for local levies and bonds reached all-time lows. This local revolt was not limited to whites, nor did it portend rising conservatism. Instead, it was rooted in lower- and middle-income Americans’ frustrations with steep rises in unfair, regressive taxes during the post–World War II decades. The Kennedy-Johnson “Growth Liberals,” who were busy cutting progressive federal taxes at the same time that regressive state and local taxes were soaring, missed this pocketbook squeeze, thereby setting the stage for later events like Prop 13.
Association of seasonality and serum albumin concentration with vitamin D deficiency in subjects with chronic hepatitis C infection living in a sunny country
Authors: Pott-Junior Henrique , Luzeiro Camila , Senise Jorge Figueiredo , Castelo Adauto 
Published: March 2020

AbstractObjective:This study aimed to analyse the relationship between vitamin D deficiency and the season when the blood sample was obtained from subjects with chronic hepatitis C (CHC) infection.Design:A cross-sectional study was conducted on a representative sample. Vitamin D deficiency was defined as a serum 25-hydroxyvitamin D [25(OH)D] concentration <50 nmol/l, based on the values set forth by the Endocrine Society guideline for higher-risk populations. Seasonality was defined according to solstices and equinoxes. The association of seasonality and clinical/laboratory characteristics with vitamin D deficiency was assessed using a multivariate logistic regression analysis.Setting:NUPAIG Viral Hepatitis Outpatient Clinic of the Universidade Federal de São Paulo – Brazil.Participants:Adult subjects with CHC infection (n 306).Results:The prevalence of vitamin D deficiency was 16 %, whereas the median serum 25(OH)D concentration was 87 (interquartile range, 59; third quartile = 118) nmol/l. Serum concentration was consistently lower in samples collected in spring and winter than in other seasons. In multivariate analysis, vitamin D deficiency was found to be independently associated with male gender, serum albumin concentration and with samples drawn in winter and spring.Conclusions:The findings show not only the relevance to consider season as a factor influencing 25(OH)D concentration but also the need to actively screen for hypovitaminosis D in all patients with CHC infection, especially in females and those with low albumin concentration.
Association of all forms of malnutrition and socioeconomic status, educational level and ethnicity in Colombian children and non-pregnant women
Authors: Cediel Gustavo , Perez Eliana , Gaitán Diego , Sarmiento Olga L , Gonzalez Laura 
Published: March 2020

AbstractObjective:To examine the association of all forms of malnutrition and socioeconomic status (SES), educational level and ethnicity in children <5 years, non-pregnant adolescent women (11–19 years) and non-pregnant adult women (20–49 years) in Colombia.Design:Cross-sectional analysis of data from the 2010 Colombian National Nutrition Survey. The prevalence of malnutrition was compared across categories of SES, educational level and ethnicity.Setting:Colombia.Participants:The sample for the current analysis comprised children <5 years, non-pregnant adolescent women (11–19 years) and non-pregnant adult women (20–49 years).Results:In children <5 years, a low SES and maternal educational level were significantly associated with a lower prevalence of overweight/obesity compared with high levels of SES and maternal education, that is, the prevalence of overweight/obesity was 1·4 and 1·6 times lower in categories of low SES and educational levels, respectively. In contrast, the prevalence of wasting, stunting and anaemia was higher in the lowest SES and maternal educational categories (the prevalence was between 1·1 and 1·8 times higher for these indicators). In women, the lowest SES (11 and 19 years) and educational levels (20 and 49 years) exhibited a higher prevalence in all forms of malnutrition compared with their counterparts in the highest categories (i.e. overweight/obesity, stunting and anaemia). Additionally, indigenous or Afro-Colombian children and women had the highest prevalence of malnutrition in comparison with other ethnicities.Conclusions:These results suggest that public policies should address all forms of malnutrition that occur in the most vulnerable populations in Colombia using multiple strategies.
Morphological, Molecular, and Pathological Appraisal ofHymenolepis nana(Hymenolepididae) Infecting Laboratory Mice (Mus musculus)
Authors: Al-Olayan Ebtsam , Elamin Maha , Alshehri Eman , Aloufi Abeer , Alanazi Zainab , Almayouf Mina , Bakr Lamia , Abdel-Gaber Rewaida 
Published: March 2020

AbstractHymenolepis nana, typically a parasite found in conventionally established mouse colonies, has zoonotic potential characterized by autoinfection and direct life cycle. The objective of this study was to determine the rate of parasite infection in laboratory mice. The hymenolepidide cestode infected 40% of the 50 mice sampled. The rate of infection in males (52%) was higher than in females (28%). Morphological studies on the cestode parasite showed that worms had a globular scolex with four suckers, a retractable rostellum with 20–30 hooks, and a short unsegmented neck. In addition, the remaining strobila consisted of immature, mature, and gravid proglottids, irregularly alternating genital pores, lobulated ovaries, postovarian vitelline glands, and uteri with up to 200 eggs in their gravid proglottids. The parasite taxonomy was confirmed by using molecular characterization based on the sequence analysis of the mitochondrial cytochromecoxidase subunit 1 (mtCOX1) gene. The parasite recovered was up to 80% identical to other species in GenBank. High blast scores and low divergence were noted between the isolated parasite and previously describedH. nana(gb| AP017666.1). The phylogenetic analysis using theCOX1sequence places this hymenolepidid species of the order Cyclophyllidea.
Communication about the desire to die: Development and evaluation of a first needs-oriented training concept — A pilot study
Authors: Frerich Gerrit , Romotzky Vanessa , Galushko Maren , Hamacher Stefanie , Perrar Klaus Maria , Doll Axel , Montag Thomas , Golla Heidrun , Strupp Julia , Kremeike Kerstin , Voltz Raymond 
Published: March 2020

AbstractObjectivePatients’ desire to die (DD) is rarely discussed in palliative care (PC) due to health professionals’ (HPs) feeling of uncertainty. The aim of the study was to develop and evaluate a training to increase HPs’ self-confidence in responding professionally to patient's DD and to assess the feasibility of this approach.MethodsThe training course was developed via focus groups and relevant literature and refined with an advisory board. An evaluation design was developed to evaluate training outcomes and to examine feasibility. To assess self-confidence, knowledge, skills, and attitudes: (1) standardized surveys were applied at T1 (before training), T2 (directly after), and T3 (3 months later), and were analyzed by descriptive and non-parametric statistics; and (2) participants’ open feedback was summarized by content.ResultsA two-day multi-disciplinary training was developed to improve self-confidence via diverse teaching methods. Twenty-four HPs from general and specialized PC were participated. Via self-rating on Likert scales at three time points, improvements were seen at T1, T2, and partly remained at T3, especially in the overall item of self-confidence in communicating with patients about their DD (means: 4.3. at T1, 5.7 at T2, and 5.9 at T3; on a 7-point scale with 1 = lowest value and 7 = highest value). Fewer improvements were found in skills (using different approaches) and attitudes (feeling less helplessness). Open feedback revealed a high appreciation for the training, especially the composition of participants, the role-play, and the overall increase of awareness of the topic.Significance of resultsThe developed training on addressing DD meets a need and was perceived by the participants to be of added value. Future research should measure training effects with a validated instrument, including more participants, diverse participant groups, and a control group. Effects on patients should be assessed.
Implementing Inclusion: Gender Quotas, Inequality, and Backlash in Kenya
Authors: Berry Marie E. , Bouka Yolande , Kamuru Marilyn Muthoni 
Published: March 2020

AbstractExtensive research has affirmed the potential of gender quotas to advance women's political inclusion. When Kenya's gender quota took effect after a new constitution was promulgated in 2010, women were elected to the highest number of seats in the country's history. In this article, we investigate how the process of implementing the quota has shaped Kenyan women's power more broadly. Drawing on more than 80 interviews and 24 focus groups with 140 participants, we affirm and refine the literature on quotas by making two conceptual contributions: (1) quota design can inadvertently create new inequalities among women in government, and (2) women's entry into previously male-dominated spaces can be met with patriarchal backlash, amplifying gender oppression. Using the ongoing process of quota implementation in Kenya as a case to theoretically question inclusionary efforts to empower women more generally, our analysis highlights the challenges for implementing women's rights laws and policies and the need for women's rights activists to prioritize a parallel bottom-up process of transforming gendered power relations alongside top-down institutional efforts.
Linking Global Land Use/Land Cover to Hydrologic Soil Groups From 850 to 2015
Authors: Wang Pei‐Ling , Feddema Johannes J. 
Published: March 2020

AbstractThe characteristics of soils in part determine human‐induced land use and land cover (LULC) change, and together, soil properties and LULC directly impact global water, energy, and biogeochemical cycles. Plant health and the exchange of energy, water, and biogeochemical components at the surface interface are partly controlled by soil properties. Different soil types modify vegetation responses to existing climate forcings, and each soil type also responds differently to the same land‐use practice. Currently, Earth system models often use single soil columns with averaged properties. This leads to uncertainties in assessing LULC impacts. To improve the estimates of land surface change in Earth System Models, we link an existing LULC data set to four hydrologic soil groups from 850 to 2015, based on demonstrated soil preferences for eight LULCs under current conditions. We conclude that humans prefer hydrologic soil groups in order from B, D, C, to A. This ranking was applied to construct the history of LULC on each soil type at the 0.5° grid resolution. Results primarily distribute croplands to hydrologic soil group B in 850, while hydrologic soil group A has the most undisturbed area. Over time, good soils (hydrologic soil groups B and D) experience increased use for cropland areas, while poor soils (hydrologic soil groups C and A) are occupied predominantly by increasing areas in grazing land and secondary nonforests. The results provide better land surface characteristics to improve Earth systems modeling.
Long Memory Impact of Ocean Mesoscale Temperature Anomalies on Tropical Cyclone Size
Authors: Bruneau N. , Wang S. , Toumi R. 
Published: March 2020

AbstractMesoscale ocean temperature anomalies modify a tropical cyclone (TC). Through a modeling study we show that, while the maximum wind speed is rapidly restored after the TC passes a warm‐ or cold‐ (eddy size) sea surface temperature (SST) anomaly, the storm size changes are more significant and persistent. The radius of gale force winds and integrated kinetic energy (IKE) can change by more than 10% per degree and this endures several days after crossing an SST anomaly. These properties have a long memory of the impact from the ocean fluxes and depend on the integrated history of SST exposure. They are found to be directly proportional to the storm total precipitation. Accurate continuous forecast of the SST along the track may therefore be of central importance to improving predictions of size and IKE, while instantaneous local SST near the TC core is more important for the forecast of maximum wind speed.