bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of electrophoretic deposition process parameters on the mechanical properties of graphene carboxyl‐grafted carbon fiber reinforced polymer composite
Authors: Yandrapu Sagar , Gangineni Pavan K. , Ramamoorthy Sunil K. , Ray Bankim C. , Prusty Rajesh K. 
Published: January 2020

ABSTRACTCarbon fiber (CF) modification by grafting of various graphene‐based nanofillers (GBN) by electrophoretic deposition (EPD) technique was proven to be a successful technique to enhance the out‐of‐plane performance of carbon fiber reinforced polymer (CFRP) composites. Graphene carboxyl (G‐COOH) grafting on carbon fiber by electrophoretic deposition (EPD) is a promising technique to improve the mechanical properties of CFRP composites. To our knowledge, there is a dearth of literature available on the effect of EPD process parameters on the mechanical behavior of modified CFRP composites. The aim of this study is to evaluate the effect of nanofiller concentration in the suspension, applied current, and the time of deposition during EPD on the mechanical behavior of nanophase CFRP composites, thus making it a novel work. With increasing concentration, interlaminar shear strength (ILSS) improved consistently and has shown a maximum enhancement of 24.7% than that of neat CFRP composite at 1.5 g/L nanofiller concentration, whereas flexural strength remained almost unaffected with varying concentration. On the contrary, variation of deposition current has affected the flexural strength but not ILSS. The maximum flexural strength was obtained at a deposition current of 5.0A with an improvement of 16.3% in comparison with neat CFRP samples. However, both flexural strength and ILSS of hybrid CFRP composites have shown improvement with increasing deposition time. At 60 min of deposition, ILSS and flexural strength have shown maximum improvements of 35.0 and 26.6%, respectively, when compared to control specimen. After evaluating the effect of process parameters future scope of the work involves the optimization of parameters for EPD of G‐COOH. Fractographic analysis of the fractured samples was performed using scanning electron microscope (SEM) to apprehend prominent failure mechanisms. © 2020 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48925.
Preparation of sulfonated polysulfone/sulfonated titanium dioxide hybrid membranes for DMFC applications
Authors: Zhang Xinxin , Xia Yifan , Gong Xinjian , Geng Pengfei , Gao Zhenwei , Wang Yinghan 
Published: January 2020

ABSTRACTSulfonated titanium dioxide (STiO2) was prepared by the reaction of TiO2 with 1,3‐propanesultone. Novel STiO2 incorporated sulfonated poly(aryl ether sulfone) (SPAES) nanocomposite proton exchange membranes (PEMs) were made by solution casting. Fourier transform infrared, X‐ray photoelectron spectroscopy, and proton nuclear magnetic resonance indicated the successful preparation of STiO2 and SPAES. The thermogravimetric analysis and oxidative stability testing results implied that SPAES/STiO2 membranes had better stability than pristine SPAES membrane. Meanwhile, the scanning electron microscopy spectra exhibited that the introduction of sulfonated groups on the surface of TiO2 significantly improved its dispersibility in SPAES matrix. More specifically, SPAES membrane incorporated with 2%STiO2 exhibited higher proton conductivity (60 mS cm−1), lower methanol permeability (2.1 × 10−7 cm2 s−1) and better proton selectivity (28.0 × 104 S s cm−3) than that of pure SPAES and SPAES/1%TiO2 membrane. The SPAES‐1%STiO2 membrane showed better performance in direct methanol fuel cell (DMFC) test than SPAES and Nafion 117 due to the reduction of methanol crossover. From these results, it is evident that SPAES/STiO2 nanocomposite PEMs have great potential for applications in DMFCs. © 2020 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48938.
Serum proteins TGFBI, PCSK9, and CCL14 are potential biomarkers for different traditional Chinese medicine syndromes of multidrug‐resistant tuberculosis
Authors: Hu Yu‐Ting , Yi Wen‐Jing , Jiang Ting‐Ting , Tu Hui‐Hui , Wei Li‐Liang , Shi Li‐Ying , Liu Chang‐Ming , Chen Jing , Han Yu‐Shuai , Gan Lin , Li Zhi‐Bin , Huang Huai , Li Ji‐Cheng 
Published: January 2020

AbstractPatients with multidrug‐resistant tuberculosis (MDR‐TB) tend to have a long course of anti‐TB treatment and severe side effects. Traditional Chinese Medicine (TCM) has a synergistic effect in attenuation of MDR‐TB. However, the lack of objective biological standards to classify and diagnose MDR‐TB TCM syndromes could result in less effective TCM treatment. Therefore, in this study, we identified differentially expressed proteins (DEPs) in serum of individuals with MDR‐TB TCM syndromes by applying isobaric tags for relative and absolute quantification coupled with two‐dimensional liquid chromatography–tandem mass spectrometry (iTRAQ‐2DLC–MS/MS) method and bioinformatics analysis. The functional analysis of DEPs was also performed. Additionally, DEPs among three different TCM syndromes of MDR‐TB were validated by enzyme‐linked immunosorbent assay (ELISA). Finally, a receiver operating characteristic (ROC) curve was performed to estimate the diagnostic ability of DEPs. A total of 71 DEPs were identified in the three different MDR‐TB TCM syndrome groups such as the pulmonary Yin deficiency (PYD) syndrome group, the Hyperactivity of Fire due to Yin deficiency (HFYD) syndrome group, and the deficiency of Qi and Yin (DQY) syndrome group. The results showed that the expression level of transforming growth factor‐beta‐induced protein ig‐h3 (TGFBI) was lower in the PYD syndrome group (p = .002), the proprotein convertase subtilisin/kexin type 9 (PCSK9) was overexpressed in the HFYD syndrome group (p < .0001), and the C–C motif chemokine ligand 14 (CCL14) expression level was reduced in the DQY syndrome group (p = .004). Our study demonstrated that serum TGFBI, PCSK9, and CCL14 may serve as potential novel biomarkers for PYD syndrome, HFYD syndrome and DQY syndrome of MDR‐TB, respectively. The study provides a biological basis for MDR‐TB TCM syndromes classification and can be of great significance for the treatment of different TCM syndromes.
Static universe model existing due to the matter‐dark energy coupling
Authors: Cabo Bizet Alejndro , Cabo Montes de Oca Alejandro 
Published: January 2020

AbstractThe work investigates a static, isotropic, and almost homogeneous Universe containing a real scalar field modeling the dark energy (DE) (quintessence) interacting with pressureless matter. It is argued that the interaction between matter and the DE is essential for the very existence of the considered solution. Assuming the possibility that DE can be furnished by the Dilaton (a scalar field reflecting the condensation of string states with zero angular momentum), we fix the value of scalar field at the origin to the Planck scale. It became possible to fix the ratio of the amount of DE to matter energy, in the currently estimated value and also the observed magnitude of the Hubble constant. The mass of the scalar field chosen for fixing the above ratio and Hubble effect strength, results to be of the order of 10−29 cm−1, a small value which seems to be compatible with the zero mass of the Dilaton in the lowest approximations.
Matching one‐loop divergences in 7D Einstein and 6D Conformal Gravities
Authors: Aros Rodrigo , Bugini Fabrizzio , Díaz Danilo E. 
Published: January 2020

AbstractWithin the context of AdS/CFT correspondence, we first compute the one‐loop infrared (IR) divergences of 7D Einstein gravity in a certain Poincaré‐Einstein background metric. Then, we compute the one‐loop ultraviolet (UV) divergences of 6D conformal gravity on the conformal boundary. We verify the equality of the above results that stem from the IR–UV connection of the duality dictionary. Key ingredients are heat kernel techniques, factorization of the boundary higher‐derivative kinetic operator for the Weyl graviton on the 6D Einstein metric, and Wentzel–Kramers–Brillouin (WKB) exactness of the Einstein graviton in the chosen 7D Poincaré‐Einstein background. Overall, we elucidate the way in which the 6D results containing the type‐A and type‐B conformal anomalies for the Weyl graviton are encoded in the 7D “hologram” given by the fluctuation determinant for the Einstein graviton. We finally discuss possible extensions to include higher‐spin fields.
A Magnetic Resonance Spectroscopy Study of Superior Visual Search Abilities in Children with Autism Spectrum Disorder
Authors: Edmondson David A. , Xia Pingyu , McNally Keehn Rebecca , Dydak Ulrike , Keehn Brandon 
Published: January 2020

Although diagnosed on the basis of deficits in social communication and interaction, autism spectrum disorder (ASD) is also characterized by superior performance on a variety of visuospatial tasks, including visual search. In neurotypical individuals, region‐specific concentrations of the inhibitory neurotransmitter gamma‐aminobutyric acid (GABA) are associated with individual differences in attention and perception. While it has been hypothesized that ASD may be associated with an excitatory–inhibitory imbalance, it remains unclear how this may contribute to accelerated visual search performance in individuals with ASD. To investigate this, 21 children with ASD and 20 typically developing children participated in a visual search task and a magnetic resonance spectroscopy study to detect neurochemical concentrations, including GABA. Region‐specific neurochemicals were examined in the right frontal eye fields, right temporal–parietal junction (rTPJ), and bilateral visual cortex (VIS). GABA concentrations did not differ between groups; however, in children with ASD, greater GABA concentration in the VIS was related to more efficient search. Additionally, lower VIS GABA levels were also associated with increased social impairment. Finally, we found reduced N‐acetyl aspartate, total creatine, glutamate and glutamine (Glx), GABA/Glx in the rTPJ, suggestive of neuronal dysfunction in a critical network hub. Our results show that GABA concentrations in the VIS are related to efficient search in ASD, thus providing further evidence of enhanced discrimination in ASD. Autism Res 2020, 13: 550–562. © 2019 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryChildren with autism spectrum disorder (ASD) often perform better than their non‐ASD peers on visual search tasks; however, it is unclear how they achieve this superior performance. Using magnetic resonance spectroscopy to measure neurochemicals in the brain, we found that the level of one, gamma‐aminobutyric acid, in the visual cortex was directly related to search abilities in children with ASD. These results suggest that faster search may relate to enhanced perceptual functioning in children with ASD.
Tapping enhances vasodilation for venipuncture even in individuals with veins that are relatively difficult to palpate
Authors: Ichimura Mika , Sasaki Shinsuke , Ogino Tetsuya 
Published: January 2020

AbstractIntroductionThis study evaluated whether tapping enhances vasodilation in individuals with veins that are relatively difficult to palpate.Materials and MethodsTwenty participants (4 men and 16 women, aged 19–22 years) with cutaneous veins that were relatively difficult to palpate even after tourniquet application were recruited. A crossover trial with/without tapping (10 times in 5 s) was performed under tourniquet inflation on the upper arm. Vasodilation was evaluated by venous cross‐sectional area, depth of the vein, and elevation of the overlying skin by ultrasonography. Venous palpation scores were also measured. The degree of improvement was estimated by simulation.ResultsIn total, 60% of participants “sometimes” or “often” experienced unsuccessful venipuncture. After the tapping procedure, the venous cross‐sectional area significantly increased (14.6 ± 9.12 mm2 for control and 15.2 ± 9.79 mm2 for tapping) and venous depth significantly decreased (4.57 ± 2.31 mm for control and 4.23 ± 2.41 mm for tapping). A simulation study using these values suggested that tapping increased the longitudinal and crosswise successful ranges of venipuncture by 5–6%.ConclusionsTapping in this study enhanced the vasodilation of cutaneous veins that are relatively difficult to palpate. The effectiveness of various vasodilation methods may be compared through the estimation of improvement.
First‐in‐man study of a thinner‐strut sirolimus‐eluting bioresorbable scaffold (FUTURE‐I): Three‐year clinical and imaging outcomes
Authors: Song Lei , Sun Zhongwei , Guan Changdong , Yan Hongbing , Yu Mengyue , Cui Jingang , Mu Chaowei , Qiu Hong , Tang Yida , Zhao Yanyan , Qiao Shubin , Suryapranata Harry , Gao Runlin , Xu Bo ,   for the FUTURE‐I Investigators
Published: January 2020

AbstractObjectivesThe FUTURE‐I study aimed to assess preliminary safety and effectiveness with the long‐term clinical and imaging follow‐up for the Firesorb (MicroPort, Shanghai, China), a thinner‐strut sirolimus‐eluting bioresorbable scaffold (BRS).BackgroundFirst‐generation BRS has been associated with unexpected device‐related adverse outcomes at long‐term follow‐up.MethodsIn this prospective, open‐label, first‐in‐man study, patients with single de novo lesions in native coronary arteries were randomized 2:1 into two cohorts after successful Firesorb implantation: cohort 1 (n = 30) underwent multimodality imaging assessment at 6 and 24 months; and cohort 2 (n = 15) at 12 and 36 months. All patients underwent clinical follow‐up at 1, 6, and 12 months and annually up to 5 years.ResultsBetween January and March 2016, 45 patients were enrolled. At 3‐year follow‐up, one patient had experienced target lesion failure and none scaffold thrombosis. In‐scaffold minimal lumen diameter decreased significantly from 6‐month to 2‐year (2.53 ± 0.24 mm vs. 2.27 ± 0.37 mm, p = .0003), and only numerically from 1‐year to 3‐year follow‐up (2.48 ± 0.28 mm vs. 2.22 ± 0.13 mm, p = .08). By optical coherence tomography, neointimal strut coverage at 3‐year follow‐up was 99.8%, and very low rate of late scaffold discontinuity was observed, only in one patient on two cross sections with three malapposed struts.ConclusionsAt 3‐year follow‐up of the FUTURE‐I study, implantation of the thinner‐strut Firesorb BRS appeared preliminary feasible and effective in the treatment of patients with noncomplex coronary lesions.
Effectiveness of clozapine, oxcarbazepine and rivastigmine combination in a bipolar disorder patient with initial cerebral atrophy
Authors: Morana Paolo , Mucci Federico , Baroni Stefano , Della Vecchia Alessandra , Piccinni Armando , Morana Benedetto , Marazziti Donatella 
Published: January 2020

AbstractThis paper reports the case of a 46‐year‐old woman suffering from bipolar disorder of type I with mixed features with initial fronto‐temporal atrophy. Although considered treatment‐resistant to conventional strategies, she successfully responded to a combination of rivastigmine, clozapine, and oxcarbazepine.
Primary diffuse large B‐cell lymphoma presenting as acute appendicitis: A report of 2 cases and a literature review
Authors: Fernandez Turizo Maria Jose , Kharfan‐Dabaja Mohamed A. , Alhaj Moustafa Muhamad , Ayala Ernesto , Jiang Liuyan , Parrondo Ricardo 
Published: January 2020

AbstractPrimary appendiceal lymphomas (PAL) are a type of primary gastrointestinal non‐Hodgkin lymphoma (PGINHL) with an incidence of <1%. There is considerable discordance with regard to the optimal management of PGINHL. We describe two cases of PAL, perform a literature review, and discuss the available evidence for optimal treatment.
Dual Mechanoenzymatic Kinetic Resolution of (±)‐Ketorolac
Authors: Pérez‐Venegas Mario , Rodríguez‐Treviño Agustín Mario , Juaristi Eusebio 
Published: January 2020

AbstractRecently, biocatalysis mediated by mechanical energy has become a convenient strategy to obtain highly valuable products following the principles of green chemistry. In particular, mechanoenzymatic techniques have allowed the isolation of chiral drugs with high enantiomeric purity. In this regard, being aware of the preponderant anti‐inflammatory activity of Ketorolac's (S)‐isomer relative to its (R)‐enantiomer, we developed a mechanoenzymatic kinetic resolution protocol using Candida antarctica Lipase B to yield both enantiomers with high enantiopurity. The significant enantiopreference of CALB for the (R)‐isomer of Ketorolac allowed the isolation of the active (S)‐enantiomer, either by means of an enantioselective esterification of racemic Ketorolac or via enantioselective hydrolysis of suitable ester derivatives. Both techniques proceeded in short reaction times, with high enantiomeric excess (>83 %), remarkable enantiodiscrimination (E≫500) and rather good conversion (46 %). Furthermore, (R)‐Ketorolac, an effective drug for ovarian cancer management, was obtained in essentially enantiopure form (ee >99 %).
1H NMR spectroscopy coupled with multivariate analysis was applied to investigate Italian cherry tomatoes metabolic profile
Authors: Masetti Olimpia , Nisini Luigi , Ciampa Alessandra , Dell'Abate Maria Teresa 
Published: January 2020

AbstractNuclear magnetic resonance (NMR) spectroscopy, in combination with different chemometric methods, was widely used for metabolomic profiling in the geographical determination of food origin. In the present study, spectra data of cherry tomatoes, collected from Pachino (Sicily) and Sabaudia (Latium), were analyzed by principal component analysis (PCA), k nearest neighbors (kNN), and partial least‐squares discriminant analysis (PLS‐DA) in order to discriminate the samples according to their geographical provenance.The PCA analysis of 1H NMR spectra of Sabaudia cherry tomatoes showed significant differences linked to the production year: phospholipids had higher levels in 2004, but less amounts of polyunsaturated acids and lycopene were observed with respect to the year 2005. Despite the annual differences in 1H NMR metabolic profile of Sabaudia cherry tomatoes, using unsupervised (PCA) and supervised (PLS‐DA, kNN) approaches, the geographical origin differentiation was obtained. In fact, the kNN algorithm correctly classified approximately 84% to 87% of Pachino samples and 77% of Sabaudia ones with recognition ability varied from 82% to 84.4% and prediction ability (CV) of 76.2% and 94.7%. The PC1 component, with 53% of total variance, greatly separated Pachino cherry tomatoes from Sabaudia ones and PLS‐DA model showed a good degree of separation with recognition ability of 100% and prediction ability (CV) of 93% to 100%.PCA and PLS‐DA combined analysis highlighted the most prominent spectral areas that well separated the two groups of samples. So, phytosterols were found discriminating compounds according to PCA and PLS‐DA and differences in aroma components were observed mainly in PCA analysis.
Co‐hydrolysis and Seed‐Induced Synthesis of Basic Mesoporous ZSM‐5 Zeolites with Enhanced Catalytic Performance
Authors: Ye Zhaoqi , Zhao Yang , Zhang Hongbin , Zhang Yahong , Tang Yi 
Published: January 2020

AbstractFor zeolite catalysts, the regulation of active site and pore structure plays an important role in the enhancement of their catalytic performance. In this work, a one‐pot and organic template‐free co‐regulation route is proposed to straightforwardly synthesize basic mesoporous ZSM‐5 zeolites with adjustable alkaline‐earth metal species. The synthesis pathway combines two decisive strategies: 1) the seed‐induced interface assembly growth method and 2) the acidic co‐hydrolysis/condensation of aluminosilicate species and alkaline‐earth metal (e.g., Mg, Ca, Sr, or Ba) sources. It is interesting that the mesoporous structure was self‐evolved through particle‐attached seed‐interfacial crystallization without the assistance of any template. Meanwhile, the incorporation of alkaline‐earth metals species is homogeneous and highly dispersed in the solid products during the whole crystallization process, and finally generate the superior basicity. Catalysis tests of the as‐synthesized samples displayed their novel performance in the typical base reaction of Knoevenagel condensation, even for bulky substrates owing to the enhanced diffusion arising from the meso/microporous network. This finding opens new possibilities for facile, cost‐effective, and environmentally friendly synthesis of mesoporous high‐silica zeolites with tunable acid/base properties, and deepens our understanding of the particle‐attached crystallization.
Pressure Sensitivity of SynGAP/PSD‐95 Condensates as a Model for Postsynaptic Densities and Its Biophysical and Neurological Ramifications
Authors: Cinar Hasan , Oliva Rosario , Lin Yi‐Hsuan , Chen Xudong , Zhang Mingjie , Chan Hue Sun , Winter Roland 
Published: January 2020

AbstractBiomolecular condensates consisting of proteins and nucleic acids can serve critical biological functions, so that some condensates are referred as membraneless organelles. They can also be disease‐causing, if their assembly is misregulated. A major physicochemical basis of the formation of biomolecular condensates is liquid–liquid phase separation (LLPS). In general, LLPS depends on environmental variables, such as temperature and hydrostatic pressure. The effects of pressure on the LLPS of a binary SynGAP/PSD‐95 protein system mimicking postsynaptic densities, which are protein assemblies underneath the plasma membrane of excitatory synapses, were investigated. Quite unexpectedly, the model system LLPS is much more sensitive to pressure than the folded states of typical globular proteins. Phase‐separated droplets of SynGAP/PSD‐95 were found to dissolve into a homogeneous solution already at ten‐to‐hundred bar levels. The pressure sensitivity of SynGAP/PSD‐95 is seen here as a consequence of both pressure‐dependent multivalent interaction strength and void volume effects. Considering that organisms in the deep sea are under pressures up to about 1 kbar, this implies that deep‐sea organisms have to devise means to counteract this high pressure sensitivity of biomolecular condensates to avoid harm. Intriguingly, these findings may shed light on the biophysical underpinning of pressure‐related neurological disorders in terrestrial vertebrates.
Luminescent PtII and PtIV Platinacycles with Anticancer Activity Against Multiplatinum‐Resistant Metastatic CRC and CRPC Cell Models
Authors: Lázaro Ariadna , Balcells Cristina , Quirante Josefina , Badia Josefa , Baldomà Laura , Ward Jas S. , Rissanen Kari , Font‐Bardia Mercè , Rodríguez Laura , Crespo Margarita , Cascante Marta 
Published: January 2020

AbstractPlatinum‐based chemotherapy persists to be the only effective therapeutic option against a wide variety of tumours. Nevertheless, the acquisition of platinum resistance is utterly common, ultimately cornering conventional platinum drugs to only palliative in many patients. Thus, encountering alternatives that are both effective and non‐cross‐resistant is urgent. In this work, we report the synthesis, reduction studies, and luminescent properties of a series of cyclometallated (C,N,N′)PtIV compounds derived from amine–imine ligands, and their remarkable efficacy at the high nanomolar range and complete lack of cross‐resistance, as an intrinsic property of the platinacycle, against multiplatinum‐resistant colorectal cancer (CRC) and castration‐resistant prostate cancer (CRPC) metastatic cell lines generated for this work. We have also determined that the compounds are effective and selective for a broader cancer panel, including breast and lung cancer. Additionally, selected compounds have been further evaluated, finding a shift in their antiproliferative mechanism towards more cytotoxic and less cytostatic than cisplatin against cancer cells, being also able to oxidize cysteine residues and inhibit topoisomerase II, thereby holding great promise as future improved alternatives to conventional platinum drugs.