bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simone de Beauvoir et l’ « autobiographie existentialiste »
Authors: Jeannelle Jean-Louis 
Published: December 2019

Résumé
Nous verrons que le désintérêt à peine voilé de Michael Sheringham, comme de Philippe Lejeune avant lui, à l’ égard des Mémoires d’ une jeune fille rangée tient à leur valorisation excessive du pacte autobiographique. Or, tout en s’ inscrivant dans la nébuleuse des autobiographies existentialistes, le récit de Simone de Beauvoir s’ en démarque, en particulier par le rôle qu’ y joue le genre des Mémoires en creux, ou plus précisément à l’ horizon du texte de 1958. Il s’ agira de montrer que le premier volume du cycle beauvoirien occupe au sein des récits de soi existentialistes une place beaucoup plus centrale que ne l’ envisageait Sheringham dans French Autobiography.
Beauvoir and The Second Sex
Authors: Simons Margaret A. 
Published: December 2019

Abstract
Colette Audry pointed to a mystery in observing that during the 1930s Simone de Beauvoir had not been concerned with the “woman question” and that her friend must have encountered a “serious obstacle” that “made her change her mind” and write The Second Sex. Unfortunately, Beauvoir obscured the genesis of her most important work. Using evidence uncovered by her biographers about her relationship with Sartre, and digging more deeply into their posthumously published letters and diaries, this paper uncovers a series of events that together tell a likely story of Beauvoir’s feminist turning point.
L’analisi ġazaliana del concetto di ittiḥād
Authors: Peta Ines 
Published: December 2019

Abstract
The aim of this contribution is to highlight al-Ġazālī’s account of ittiḥād or “union” with God; to this purpose, we have traced and examined, within his works, the various passages dedicated to the subject. This analysis shows that al-Ġazālī, although critical of the doctrine of ittiḥād understood in the literal sense, accepts it in a metaphorical way, interpreting it as the state of obliteration of the self (fanā’) in the divine uniqueness (tawḥīd). Even though he defines tawḥīd, in its highest sense, as “not seeing in existence but One”, the terminological and content analysis of the ġazalian passages clearly shows, in our opinion, that he does not adhere to the monism inherent in the so-called waḥdat al-wujūd; on the contrary he strongly supports the monotheistic paradigm. The assertion that God is the only real existent – to be understood in Avicennan terms as the only necessarily existent –, does not imply in fact that creatures are deprived of their own substantial reality and is therefore consistent with the statement that everything has God as its sole creator. In this sense, the ġazalian need to point out that the “absorption” of the Sufi into God is not ittiḥād but tawḥīd is not a mere terminological issue or an instrumental attempt to make “orthodox” an “heterodox” doctrine, but it is the proper expression of the true meaning of that “absorption”, and it’s no coincidence that it corresponds to the foundation of Islam: monotheism.
Moored Observations of Transport and Variability of Halmahera Sea Currents
Authors: Li Xiang , Yuan Dongliang , Wang Zheng , Li Yao , Corvianawatie Corry , Surinati Dewi , Sandra Asep , Bayhaqi Ahmad , Avianto Praditya , Kusmanto Edi , Dirhamsyah Dirham , Arifin Zainal 
Published: December 2019

AbstractThe ocean currents in the Halmahera Sea are studied using a subsurface mooring deployed in the Jailolo Strait from November 2015 to October 2017. The subtidal currents of the mooring measurements are characterized by a two-layer system, with the current variability below about 200 m in opposite phases to that in the upper layer. The mean along-strait velocity (ASV) is toward the Indonesian seas in the whole water column, producing an estimated mean transport of 2.44 ± 0.42 Sv (1 Sv ≡ 106 m3 s−1). The errors of the transport calculation based on the single mooring measurements are estimated to be less than 15% using simulations of high-resolution ocean models. A weak current is observed to flow northward during 2017 at the bottom of the strait. The ASV variability is found to be dominated by an annual cycle both in the upper and lower layers. The total transport, however, is dominated by semiannual variability because of the cancelation of the annual transports in the upper and lower layers. The variability of the transport is suggested to be driven by the pressure difference between the Pacific Ocean and the Indonesian seas, as evidenced by the agreement between the satellite pressure gradient and the two-layer transports. The transport of the Jailolo Strait during the 2015/16 super El Niño is found to be nearly the same as that during the 2016 La Niña, suggesting that the interannual variability of the transport is much smaller than the seasonal cycle.
Interannual Variability of the Global Meridional Overturning Circulation Dominated by Pacific Variability
Authors: Tandon Neil F. , Saenko Oleg A. , Cane Mark A. , Kushner Paul J. 
Published: December 2019

AbstractThe most prominent feature of the time-mean global meridional overturning circulation (MOC) is the Atlantic MOC (AMOC). However, interannual variability of the global MOC is shown here to be dominated by Pacific MOC (PMOC) variability over the full depth of the ocean at most latitudes. This dominance of interannual PMOC variability is robust across modern climate models and an observational state estimate. PMOC interannual variability has large-scale organization, its most prominent feature being a cross-equatorial cell spanning the tropics. Idealized experiments show that this variability is almost entirely wind driven. Interannual anomalies of zonal mean zonal wind stress produce zonally integrated Ekman transport anomalies that are larger in the Pacific Ocean than in the Atlantic Ocean, simply because the Pacific is wider than the Atlantic at most latitudes. This contrast in Ekman transport variability implies greater variability in the near-surface branch of the PMOC when compared with the near-surface branch of the AMOC. These near-surface variations in turn drive compensating flow anomalies below the Ekman layer. Because the baroclinic adjustment time is longer than a year at most latitudes, these compensating flow anomalies have baroclinic structure spanning the full depth of the ocean. Additional analysis reveals that interannual PMOC variations are the dominant contribution to interannual variations of the global meridional heat transport. There is also evidence of interaction between interannual PMOC variability and El Niño–Southern Oscillation.
Understanding what works, why and in what circumstances in hospice at home services for end-of-life care: Applying a realist logic of analysis to a systematically searched literature review
Authors: Hashem Ferhana , Brigden Charlotte , Wilson Patricia , Butler Claire 
Published: December 2019

Background: We have undertaken a systematically searched literature review using a realist logic of analysis to help synthesise the diverse range of literature available on hospice at home services. Aim: To find out in the existing literature what features of hospice at home models work best, for whom and under what circumstances. Design: A realist logic of analysis was applied to synthesise the evidence focusing on mechanisms by which an intervention worked (or did not work). An initial programme theory was developed using the National Association for Hospice at Home standards, Normalisation Process Theory and through refinement using stakeholder engagement. Data sources: PubMed, Science Direct, AMED, BNI, CINAHL, EMBASE, Health Business Elite, HMIC, Medline, PsychINFO, SCOPUS, Web of Science, DARE, Google Scholar, NHS Evidence, NIHR CRN portfolio database, NIHR journal library of funded studies, including searches on websites of relevant professional bodies (August 2014, June 2017, June 2019). Results: Forty-nine papers were reviewed, of which 34 contributed evidence to at least one of the eight theory areas: marketing and referral, sustainable funding model, service responsiveness and availability, criteria for service admission, knowledge and skills of care providers, integration and coordination, anticipatory care, support directed at carers. Conclusions: Our literature review showed how it was possible to develop a coherent framework and test it against 34 published papers and abstracts. Central to this review was theory building, and as further evidence emerges, our programme theories can be refined and tested against any new empirical evidence.
Eribulin plus trastuzumab in pretreated HER2-positive advanced breast cancer patients: safety and efficacy. An Italian experience
Authors: Lutrino Eufemia S. , Orlando Laura , Febbraro Antonio , Giampaglia Marianna , Zamagni Claudio , Schiavone Paola , Scavelli Claudio , Dima Gianluca , Fedele Palma , Giordano Guido , Bilancia Domenico , Quaranta Anna Maria , Rubino Daniela , Filippelli Gianfranco , Fontanella Caterina , Caliolo Chiara , Marino Antonella , Calvani Nicola , Ferrara Pasqualinda , Cinieri Saverio 
Published: December 2019

Background: Chemotherapy plus targeted therapy is the established treatment for human epidermal growth factor receptor 2 (HER2)–overexpressing breast cancer (BC). Limited data regarding the safety and activity of the combination of eribulin and trastuzumab (E/T) in pretreated HER2-positive advanced BC (ABC) are available. The aim of this observational, retrospective, multicenter study was to examine the tolerability and the clinical activity of E/T in this setting. Methods: Patients treated with eribulin mesylate plus standard dose of trastuzumab were included. Data on overall response rate (ORR), progression-free survival (PFS), overall survival (OS), and safety were reported. Results: Between October 2012 and November 2015, 24 consecutive patients with HER2-positive ABC were included. All patients were heavily pretreated: the median number of prior chemotherapy regimens for ABC was 3 (range 2–9). The median number of cycles with E/T was 11.5 (range 2–26). The ORR was 41.7%. Median PFS was 5.4 months, median postprogression survival was 5.4 months, and median OS was 8 months. Neutropenia was the most common grade 3/4 clinical adverse event (16.7%). Conclusions: Tolerability and clinical activity of the E/T combination schedule are encouraging. The results of this study indicate that this combination might be considered for treatment of pretreated HER2 ABC.
Continuous veno-venous hemofiltration in the treatment of severely burned patients with acute hypernatremia: A retrospective study of 13 cases
Authors: Huang Chen , Liu Yirong , Li Li , Liu Hongbao , Zhang Peng 
Published: December 2019

Objectives: This study aimed to evaluate the clinical effects of continuous veno-venous hemofiltration in the treatment of severely burned patients with acute hypernatremia. Methods: A total of 13 severely burned patients with acute hypernatremia admitted to Xijing Hospital were included in this study. All patients received continuous veno-venous hemofiltration treatment in addition to conventional treatment. The original sodium level in the replacement fluid was set to be lower than the serum sodium level by 8 mmol/L and subsequently undergoes a reduction rate of 2.16 ± 0.18 mmol/L every 4 h. Patients’ clinical features, serum laboratory tests, hemodynamic variables, changes in sodium levels in serum, and replacement fluid during continuous veno-venous hemofiltration treatment were monitored. Results: Patients had an average total burn surface area of 66.69% ± 20.28%. Two patients died of systematic Pseudomonas aeruginosa infections, and 11 patients survived. After continuous veno-venous hemofiltration treatment, patients showed a significant reduction in the serum sodium level (168.91 ± 4.88 mmol/L vs 144.62 ± 2.98 mmol/L, p < 0.01). Likewise, the serum levels of urea and creatinine decreased from 24.8 ± 6.5 mmol/L to 14.9 ± 8.3 mmol/L and from 278.6 ± 155.3 μmol/L to 152.6 ± 29.7 μmol/L, respectively (p < 0.05). The patients also displayed improvements in the Acute Physiology and Chronic Health Evaluation II and Glasgow scores (p < 0.05) and showed a significant reduction in hemoglobin and serum albumin levels (p < 0.05), but no obvious change in levels of platelets, alanine aminotransferase, and aspartate aminotransferase (p > 0.05). Conclusion: Our results indicate that continuous veno-venous hemofiltration with gradient sodium replacement fluid is effective in treating hypernatremia in severely burned patients with the controllable sodium reduction rate and satisfactory clinical outcomes.
The possibility of using effluent ionized calcium to assess regional citrate anticoagulation in continuous renal replacement therapy
Authors: Zhang Qi , Zhuang Feng , Fan Qichen , Yu Wenyan , Ding Feng 
Published: December 2019

Aim: This study aimed to investigate whether effluent ionized calcium was an appropriate indicator to assess anticoagulant effect in continuous renal replacement therapy with regional citrate anticoagulation instead of post-filter ionized calcium. Methods: In total, 48 paired samples of effluent fluid and post-filter blood were obtained from critically ill patients who required continuous renal replacement therapy. All samples were taken for ionized calcium measurements and were assessed by point-of-care analyzer. Correlations and agreements between two methods were performed by Pearson linear analysis and Bland–Altman analysis accordingly. Results: The mean post-filter ionized calcium was 0.42 ± 0.12 mmol/L, and mean ionized calcium level of effluent fluid was 0.39 ± 0.11 mmol/L. The ionized calcium level of effluent fluid was significantly correlated with post-filter ionized calcium in all continuous renal replacement therapy patients. Bland–Altman analysis showed that the mean difference of ionized calcium between two sampling sites in all continuous renal replacement therapy patients was −0.02 mmol/L with 95% confidence interval ranging from −0.09 to 0.04 mmol/L. The significant correlations and agreements were also demonstrated in continuous veno-venous hemofiltration, continuous veno-venous hemodialysis, and continuous veno-venous hemodiafiltration modalities separately. Conclusion: The effluent ionized calcium could be a considerable substitute for post-filter ionized calcium to monitor the validity of regional citrate anticoagulation in continuous renal replacement therapy with less blood loss.
The Clinical Spectrum of Mosaic Neurofibromatosis in Children and Adolescents
Authors: Hom Grant L. , Moodley Sashidaran , Rothner A. David , Moodley Manikum 
Published: December 2019

Background: Segmental neurofibromatosis was initially described by Miller and Sparks (1977) as manifestations of neurofibromatosis limited to a dermatomal, localized distribution. Now termed mosaic neurofibromatosis, previous literature described this disease in children and adolescents with individual case reports and small-numbered case series. This study presents a large series of children and adolescents with mosaic neurofibromatosis. Methods: A retrospective chart review of a single institution medical record database was performed on all cases of mosaic neurofibromatosis diagnosed between the years 1998 and 2017. Eligible subjects were determined by 2 criteria: (1) segmental or unilateral expression of one of more signs of NF I according to those outlined in the NIH criteria and (2) were under 18 years of age at the time of diagnosis. Select information extracted include location of clinical features, NF manifestations (neurofibromas, plexiform neurofibromas, café-au-lait spots, freckling, Lisch nodules), presence of a diffuse area of cutaneous hyperpigmentation, and other significant medical conditions. Results: Sixty-eight cases met established criteria. Average age at diagnosis was 8.28 ± 4.47 years. Thirty-seven (54%) were male and 31 (46%) were female. Localization of the dermatologic manifestations is as follows: left side in 28 (41%) cases, right side in 32 (47%) cases, and bilateral in 8 (11%) cases. Café-au-lait lesions appeared in 64 (94%) of cases and 14 (21%) had axillary and inguinal freckling. Conclusions: This study expands our understanding of the disease characteristics seen in children and adolescents with mosaic neurofibromatosis and confirms the need to focus on pigmentary changes in children with mosaic neurofibromatosis.
Occlusion at 5 Years of Age Following Hard Palate Closure With Vestibular Flap
Authors: Otsuki Koichi , Yamanishi Tadashi , Tome Wakako , Shintaku Yuko , Seikai Tetsuya , Fujimoto Yukari , Kogo Mikihiko 
Published: December 2019

Objective: This study aims to assess occlusal relationships and frequency of oronasal fistula at 5 years of age following 2 hard palate closure techniques and to compare results. Design: Retrospective longitudinal study. Setting: Institutional study. Patients: Study patients included 57 patients with nonsyndromic complete unilateral cleft lip and palate who were consecutively treated. All patients underwent our early 2-stage protocol for palatoplasty, which consisted of soft palate plasty at 1 year of age and hard palate closure at 1.5 years of age. Twenty-nine patients underwent hard palate closure using vestibular flap (VF group) technique (2009-2011) and 28 patients underwent conventional hard palate closure with local palatal flap (LPF group) technique (2006-2008). Main Outcome Measures: Occlusal relationships were assessed with 5-year-olds’ index, and frequency of oronasal fistula was investigated. Results: Average 5-year-olds’ index scores for VF and LPF groups were 3.11 and 3.57, respectively ( P < .001). Oronasal fistula occurred in approximately 7% of patients in the VF group and in 18% of patients in the LPF group. Conclusion: Hard palate closure with VF technique may provide better occlusal relationships at 5 years of age than does conventional local closure with the LPF.
The feasibility of outpatient conversion and revision hip arthroplasty in selected patients
Authors: Crawford David A , Lombardi Adolph V , Berend Keith R , Morris Michael J , Adams Joanne B 
Published: December 2019

Background: Total hip arthroplasty (THA) continues moving to the outpatient arena, and may be feasible for some conversion and revision scenarios. Controversy surrounds appropriate patient selection. The purpose of this study is to report complications associated with outpatient revision and conversion THA, and to determine if comorbidities are associated with complications or overnight stay. Methods: From June 2013 through August 2018, 46 patients (47 hips) underwent conversion ( n = 10) or revision ( n = 37) THA at a free-standing ambulatory surgery centre. This represented only 6.3% of revision THA cases at our institution during the study period that were selected for outpatient surgery. Mean patient age was 58.0 years, and 52% of patients were males. 1 or more major comorbidities were present in 15 patients (32%) including 1 valvular disease, 7 arrhythmia, 2 thromboembolism history, 3 obstructive sleep apnoea, 3 chronic obstructive pulmonary disease, 2 asthma, 4 frequent urination, and 1 renal disease. Results: 44 (94%) patients were discharged same day without incident, none required transfer to acute facility, and 3 stayed overnight (2 convenience, 1 for medical reasons - urinary retention). The patient kept overnight for medical reasons had no major comorbidities. 3 patients were placed on an extended course of antibiotics, including 2 with positive intraoperative cultures and 1 for cellulitis. There were no major complications, readmissions, or subsequent surgeries within 90 days. Conclusions: Outpatient revision hip arthroplasty is safe in selected patients undergoing minor or partial revisions. Presence of medical comorbidities was not associated with risk of complications. Medical optimisation and a multimodal programme to mitigate risk of blood loss and reduce narcotic need facilitate the safe performance of arthroplasty in an outpatient setting.
Angelica polysaccharide ameliorates memory impairment in Alzheimer’s disease rat through activating BDNF/TrkB/CREB pathway
Authors: Du Qian , Zhu Xiaoyu , Si Jieru 
Published: December 2019

This study aimed to investigate the effect of Angelica sinensis polysaccharides (ASP) on Alzheimer’s disease (AD) and its underlying mechanisms. In our study, we build the AD model by injecting Aβ25–35. Morris water maze (MWM) was applied to investigate learning and memory. Moreover, neurotransmitters, free radical, and inflammatory factors were also measured. Pathological change and neuronal death in hippocampus CA1, CA3, and DG region were detected by HE staining and Nissl staining. The neuronal apoptosis was detected by TUNEL. The expressions of caspase-3, Bcl-2 and Bax were measured by immunohistochemistry and Western blot. The expressions of BDNF, TrkB, p-Akt, Akt, p-CREB, and CREB were measured by Western blot. Our results showed that ASP could ameliorate spatial learning and memory deficiency in AD rats. ASP decreased AchE level and increased the levels of Ach and chAT in AD rats. ASP could increase the activity of SOD and CAT, decrease MDA activity, and inhibit the expression levels of inflammatory factors and neurons apoptosis in AD rats. Pathological change of hippocampus CA1, CA3, and DG region was ameliorated by ASP. In addition, the effects of ASP were reversed by K252a (TrkB inhibitor). Our study demonstrated that ASP could ameliorate memory impairment in AD rat through activating BDNF/TrkB/CREB pathway. Impact statement The present study demonstrated that ASP could ameliorate memory impairment through regulation of the balance of neurotransmitters, free radical metabolism, inflammation, and neurons apoptosis. Moreover, the mechanism of ASP on memory impairment may be related to BDNF/TrkB/CREB pathway in AD. Our research provides an innovatively regulatory mechanism about the ASP in AD rat and points a new way to the treatment of AD.
Health-related quality of life and readmission of patients with cardiovascular disease in South Korea
Authors: Kim Hyun Su , Kim Yoonjung , Kwon Haejin 
Published: December 2019

Aims: The purpose of this study was to investigate the health-related quality of life (HRQOL) of patients with cardiovascular disease and its relationship to hospital readmission. Methods: The cross-sectional study used data from 1037 adults aged ⩾19 years diagnosed with myocardial infarction or angina pectoris. Raw data were obtained from the fourth to sixth Korea National Health and Nutrition Examination Survey (2007–2014). Results: Readmission was found to be associated with age, living status, education level, unemployment, individual income level, stroke, osteoarthritis, diabetes, depression, low stress level, walking days per week, and activity limitations due to cardiovascular disease. Conclusion: In summary, readmission was related to HRQOL among patients with myocardial infarction. Interventions that consider efforts to reduce readmission through improved diagnosis and development of systematic management of cardiovascular disease symptoms are required.