bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety of diuretic administration during the early management of dyspnea patients who are not finally diagnosed with acute heart failure
Authors: Takagi Koji , Miró Òscar , Gayat Etienne , Llorens Pere , Wussler Desiree N. , Čerlinskaitė Kamilė , Msolli Mohamed Amine , Kavoliūnienė Aušra , Sekma Adel , Čelutkienė Jelena , Nouira Semir , Gil Víctor , Martínez-Nadal Gemma , Breidthardt Tobias , Kozhuharov Nikola , Martin Jasmin , Müller Christian , Mebazaa Alexandre 
Published: April 2020

Objectives
Investigating whether it is safe or not to administrate diuretics to patients arriving at emergency departments in a stage of acute dyspnea but without a final diagnosis of acute heart failure.

Methods
We analyzed an unselected multinational sample of patients with dyspnea without a final diagnosis of acute heart failure from Global Research on Acute Conditions Team (France, Lithuania, Tunisia) and Basics in Acute Shortness of Breath Evaluation (Switzerland) registries. Thirty-day all-cause mortality and 30-day postdischarge all-cause readmission rate of treated patients with diuretics at emergency departments were compared with untreated patients by unadjusted and adjusted hazard and odds ratios. Interaction and stratified analyses were performed.

Results
We included 2505 patients. Among them, 365 (14.6%) received diuretics in emergency departments. Thirty-day mortality was 4.5% (treated/untreated = 5.2%/4.3%, hazard ratio: 1.22; 95% confidence interval, 0.75–2.00) and 30-day readmission rate was 11.3% (14.7%/10.8%, odds ratio: 1.41; 95% confidence interval, 0.95–2.11). After adjustment, no differences were found between two groups in mortality (hazard ratio: 0.86; 95% confidence interval, 0.51–1.44) and readmission (odds ratio: 1.15; 95% confidence interval, 0.72–1.82). Age significantly interacted with the use of diuretics and readmission (P = 0.03), with better prognosis when used in patients >80 years (odds ratio: 0.27; 95% confidence interval, 0.07–1.03) than in patients ≤80 years (odds ratio: 1.56; 95% confidence interval, 0.94–2.63).

Conclusions
Diuretic administration to patients presenting to emergency departments with dyspnea while they were undiagnosed and in whom acute heart failure was finally excluded was not associated with 30-day all-cause mortality and 30-day postdischarge all-cause readmission rate.
Evaluating the Discordant Relationship Between Tarlov Cysts and Symptoms of Pudendal Neuralgia
Authors: Lim Victoria M. , Khanna Rohit , Kalinkin Olga , Castellanos Mario E. , Hibner Michael 
Published: April 2020

(Abstracted from Am J Obstet Gynecol 2020;222:70.e1–70.e6)
Pudendal neuralgia is a painful chronic neuropathic pelvic condition involving the pudendal nerve dermatome. It is often debilitating and can greatly decrease quality of life among both men and women.
Embryonic Aneuploidy Rates Are Equivalent in Natural Cycles and Gonadotropin-Stimulated Cycles
Authors: Hong Kathleen H. , Franasiak Jason M. , Werner Marie M. , Patounakis George , Juneau Caroline R. , Forman Eric J. , Scott Richard T. 
Published: April 2020

(Abstracted from Fertil Steril 2019;112:670–676)
It is unclear whether controlled ovarian hyperstimulation (COH) using exogenous gonadotrophins during the in vitro fertilization (IVF) process elevates risk of meiotic or mitotic error, leading to aneuploidy. Several studies with mouse models have suggested that follicle-stimulating hormone (FSH) administration in vitro results in higher rates of aneuploidy, although studies utilizing mouse models are limited due to significantly different rates of aneuploidy and mechanistic differences between mice and humans.
Tridimensional Combined Gluteoplasty: Liposuction, Buttock Implants, and Fat Transfer
Authors: Cárdenas-Camarena Lázaro , Trujillo-Méndez Raúl , Díaz-Barriga Julio César 
Published: April 2020

Background:
There are different procedures for gluteal augmentation. The authors describe their gluteal augmentation technique, which combines buttock implant placement, frame liposuction, and lipoinjection in the lateral third of the buttock and a plane superficial to the gluteal implant.

Methods:
Patients of both sexes who underwent aesthetic gluteal augmentation with a volume deficit of the lateral third and limited fat available for grafting were included. Liposuction was performed on the periphery of the gluteus, silicone implants were placed, and lipoinjection was performed in different areas.

Results:
Fifty-two patients were included between October of 2007 and December of 2018. The average age of the patients was 33.3 years (range, 23 to 49 years); 42 women and 11 male-to-female transgender patients were included. The implants used consisted of anatomical cohesive silicone, with the most commonly used size being 300 cc (range, 200 to 500 cc). The average volume of infiltrated fat in each hip and buttock was 243.1 cc (range, 100 to 370 cc) and 141.6 cc (range, 50 to 200 cc), respectively. Partial wound dehiscence was reported in six patients (11.5 percent). In one patient who had been treated with biopolymers, the implant became exposed. All patients reported that they were highly satisfied with the results of the procedure.

Conclusions:
The combination of liposuction, buttock implant placement, and lipoinjection of the buttocks and hips is a safe procedure with a low complication rate and high level of satisfaction. This procedure is recommended in patients who require augmentation of the central and lateral portions of the buttock with insufficient fat tissue for lipoinjection.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, IV.
Nurse-Led Computerized Cognitive Training for Mild Cognitive Impairment: A Preliminary Study
Authors: Oh Min Woo , Ki Young Jin , Jeon Byoung Hyun , Kim Si Yeon , Oh Youngmin , Yoo Suwon , Cho Aeri , Seo Joo Han , Lee Goo Joo 
Published: April 2020

Abstract

Purpose
This preliminary study aimed to compare the outcomes of an occupational therapist-led and a nurse-led computerized cognitive training (CCT) for mild cognitive impairment (MCI) in older adults.

Design
A single-blind randomized controlled trial was performed.

Methods
Participants 65 years of age and older with MCI were randomly assigned to a group led by an occupational therapist or by a nurse. Both groups received CCT for 4 weeks.

Findings
Six participants in the occupational therapist-led group and nine in the nurse-led group completed CCT. The nurse-led group showed significant improvement in scores on the Seoul Verbal Learning Test–Elderly’s version immediate recall scores (p = .030) and the Korean-Boston Naming Test (p = .012).

Conclusions
Nurse-led CCT demonstrated improvement in some language and memory areas in older adults with MCI.

Clinical Relevance
This study supports the idea of educating nurses to use a CCT program for treating older adults with MCI to improve their cognitive function.
A Mathematical prediction of the time evolution of the Covid-19 pandemic in some countries of the European Union using Monte Carlo simulations
Authors: Ciufolini Ignazio , Paolozzi Antonio 
Published: April 2020

AbstractIn this paper we study the statistical evolution in time of the Covid-19 pandemic in Spain, Italy, Germany, Belgium, The Netherlands, Austria and Portugal, i.e., the countries of the European Union (EU) that have a number of positive cases higher than 12 thousand at April 7, 2020. France is the third country of the EU for number of cases but a jump in the data on April 3, 2020 does not allow, at least for the moment, to have a reliable prediction curve. The analysis is based on the use of a function of the type of a Gauss Error Function, with four parameters, as a Cumulative Distribution Function (CDF). A Monte Carlo analysis is used to estimate the uncertainty. The approach used in this paper is mathematical and statistical and thus does not explicitly consider a number of relevant issues, including number of nasopharyngeal swabs, mitigation measures, social distancing, virologic, epidemiological and models of contamination diffusion.
AN EPIDEMIOLOGICAL MODEL TO AID DECISION-MAKING FOR COVID-19 CONTROL IN SRI LANKA
Authors: Ediriweera Dileepa Senajith , de Silva Nilanthi Renuka , Malavige Neelika Gathsaurie , de Silva Hithanadura Janaka 
Published: April 2020

AbstractBackgroundSri Lanka diagnosed its first local case of COVID-19 on 11 March 2020. The government acted swiftly to contain transmission, with extensive public health measures. At the end of 30 days, Sri Lanka had 197 cases, 54 recovered and 7 deaths; a staged relaxing of the lockdown is now underway. This paper proposes a theoretical basis for estimating the limits within which transmission should be constrained in order to ensure that the case load remains within the capacity of the health system.MethodsWe used Susceptible, Infected, Recovered model to estimate the ICU bed requirement at different levels of R0 values after lockout. We developed a web application that enables visualization of cases and ICU bed requirements with time, with adjustable parameters that include: population exposed; proportion asymptomatic; number of active and recovered cases; infectious period; R0 or doubling time; proportion critically ill; available ICU beds and duration of ICU stay.ResultsThe three-day moving average of the caseload suggested two waves of transmission from Day 0 to 17 (R0=3.32, 95% CI 1.85 - 5.41) and from Day 18 - 30 (R=1.25, 95%CI: 0.93 - 1.63). We estimate that if there are 156 active cases with 91 recovered at the time of lockout, and R increases to 1.5 (doubling time 19 days), under the standard parameters for Sri Lanka, the ICU bed capacity of 300 is likely to be saturated by about 100 days, signalled by 18 new infections (95% CI 15 - 22) on Day 14 after lockout.ConclusionOur model suggests that to ensure that the case load remains within the available capacity of the health system after lockout, transmission should not exceed R=1.5. This model and the web-based application may be useful in other low- and middle-income countries which have similar constraints on health resources.
Knowledge, attitude, practice and perceived barriers among healthcare professionals regarding COVID-19: A Cross-sectional survey from Pakistan
Authors: Saqlain Muhmmad , Munir Muhammad Muddasir , Rehman Saif ur , Gulzar Aqsa , Naz Sahar , Ahmed Zaheer , Tahir Azhar Hussain , Mashhood Muhammad 
Published: April 2020

AbstractCoronavirus disease (COVID-19) is a highly transmittable infection and Pakistan faces sudden hike in number of positive cases including number of healthcare professionals (HCPs) also acquired infection. Knowledge, attitude, and practice survey provides a suitable format to evaluate existing programs and to identify effective strategies for behavior change in society. Therefore, the aim of study is to assess knowledge, attitude and practice among HCPs in Pakistan regarding COVID-19. An online survey-based study was conducted among healthcare professionals including physicians, pharmacists and nurses. A self-administered validated (Cronbach alpha= 0.077) questionnaire comprised of five sections (Demographics, Knowledge, attitude, practice and perceived barriers) were used for data collection. Of 414 participants, 29.98% (n=120) physicians, 46.65% (n= 189) pharmacists and 25.36% (n= 105%) nurses. Most commonly utilized information source was social media. Findings showed HCPs have good knowledge (93.2%, n=386), positive attitude (8.43±1.78) and good practice (88.7%, n=367) regarding COVID-19. HCPs perceived that overcrowding in emergency room (52.9%, n=219), limited infection control material (50.7%, n=210) and poor knowledge regarding transmission (40.6%, n=168) of COVID-19 are the major barriers in infection control practice. Binary logistic regression analysis demonstrated that HCPs of age group 40-49 years (OR: 1.419, 95%CI: (0.14-4.78, P=0.041) have higher odds of good knowledge. Similarly, age group of 31-39 years (OR: 1.377, 95% CI: 0.14-2.04, P=0.05), experience of more than 5 years (OR: 10.71, 95% CI: 2.83-40.75, P<0.001), and pharmacist job (OR: 2.247, 95% CI: 1.11-4.55, P=0.025) were the substantial determinants of good practice regarding COVID-19. HCPs in Pakistan have good knowledge, yet, there are areas where gaps in knowledge and practice was observed. To effectively control infection spread, well-structured training programs must be launched by government targeting all kinds of HCPs to raise their existed knowledge.
Lymphocytopaenia is associated with severe SARS-CoV-2 disease: A Systematic Review and Meta-Analysis of Clinical Data
Authors: Brown Robin , Barnard Jane , Harris-Skillman Eva , Harbinson Bronwen , Dunne Beata , Drake Jonathan , Roche Sophie , Harris Edward , Gunnell James , Frost Joshua , Angus Brian , Hodgson Susanne H 
Published: April 2020

ABSTRACTBackgroundMost patients infected by SARS-CoV-2 have favourable outcomes, however some develop severe disease which may progress to acute respiratory distress syndrome, multi-organ failure, and death. Markers that could predict patients at risk of poor outcomes would be extremely useful clinically. Evidence has emerged that low lymphocyte count is associated with increased disease severity.MethodsWe performed a systematic review and meta-analysis to assess the association between lymphocyte count and severity of SARS-CoV-2 associated clinical disease.ResultsSeven papers were included in the meta-analysis. These papers included data from 2083 patients, 25% (n=521) with severe SAR-CoV-2 disease and 75% (n=1562) with non-severe SAR-CoV-2 disease. Heterogenicity was seen in the definition of severe disease. Metanalysis produced metamedians of 1×109/L (95% CI 1-1.1) and 0.7×109/L (95% CI 0.63-0.8) lymphocytes for patients with non-severe and severe disease respectively (p-value of p=0.006 Wilcoxon test). Calculation of metamedians from the two papers classifying severe disease according to death alone gave 1.1 1×109/L lymphocytes (95% CI 1.0-1.1) for ‘survivors’ (n=163) and 0.63 1×109/L lymphocytes (95% CI 0.60-0.63) for ‘non-survivors’ (n=253) of SAR-CoV-2 disease.ConclusionsLower lymphocyte counts are significantly associated with more severe disease in patients with SARS-CoV-2 infection. Lymphocytopenia may therefore be useful laboratory measure to allow prognostication of patients presenting with SARS-CoV-2 infection.
Regulation of transcription reactivation dynamics exiting mitosis
Authors: Sarnataro Sergio , Riba Andrea , Molina Nacho 
Published: April 2020

AbstractProliferating cells experience a global reduction of transcription during mitosis, yet their cell identity is maintained and regulatory information is propagated from mother to daughter cells. Mitotic bookmarking by transcription factors has been proposed as a potential mechanism to ensure the reactivation of transcription at the proper set of genes exiting mitosis. Recently, mitotic transcription and waves of transcription reactivation have been observed in synchronized populations of human hepatoma cells. However, the study did not consider that mitotic-arrested cell populations progressively desynchronize leading to measurements of gene expression on a mixture of cells at different internal cell-cycle times. Moreover, it is not well understood yet what is the precise role of mitotic bookmarking on mitotic transcription as well as on the transcription reactivation waves. Ultimately, the core gene regulatory network driving the precise transcription reactivation dynamics remains to be identified. To address these questions, we developed a mathematical model to correct for the progressive desynchronization of cells and estimate gene expression dynamics with respect to a cell-cycle pseudotime. Furthermore, we used a multiple linear regression model to infer transcription factor activity dynamics. Our analysis allows us to characterize waves of transcription factor activities exiting mitosis and identify a core gene regulatory network responsible of the transcription reactivation dynamics. Moreover, we identified more than 60 transcription factors that are highly active during mitosis and represent new candidates of mitotic bookmarking factors which could represent relevant therapeutic targets to control cell proliferation.
Analysis of SARS-CoV-2-controlled autophagy reveals spermidine, MK-2206, and niclosamide as putative antiviral therapeutics
Authors: Gassen Nils C. , Papies Jan , Bajaj Thomas , Dethloff Frederik , Emanuel Jackson , Weckmann Katja , Heinz Daniel E. , Heinemann Nicolas , Lennarz Martina , Richter Anja , Niemeyer Daniela , Corman Victor M. , Giavalisco Patrick , Drosten Christian , Müller Marcel A. 
Published: April 2020

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses an acute threat to public health and the world economy, especially because no approved specific drugs or vaccines are available. Pharmacological modulation of metabolism-dependent cellular pathways such as autophagy reduced propagation of highly pathogenic Middle East respiratory syndrome (MERS)-CoV.Here we show that SARS-CoV-2 infection limits autophagy by interfering with multiple metabolic pathways and that compound-driven interventions aimed at autophagy induction reduce SARS-CoV-2 propagationin vitro. In-depth analyses of autophagy signaling and metabolomics indicate that SARS-CoV-2 reduces glycolysis and protein translation by limiting activation of AMP-protein activated kinase (AMPK) and mammalian target of rapamycin complex 1 (mTORC1). Infection also downregulates autophagy-inducing spermidine, and facilitates AKT1/SKP2-dependent degradation of autophagy-initiating Beclin-1 (BECN1). Targeting of these pathways by exogenous administration of spermidine, AKT inhibitor MK-2206, and the Beclin-1 stabilizing, antihelminthic drug niclosamide inhibited SARS-CoV-2 propagation by 85, 88, and >99%, respectively. In sum, SARS-CoV-2 infection causally diminishes autophagy. A clinically approved and well-tolerated autophagy-inducing compound shows potential for evaluation as a treatment against SARS-CoV-2.
Consequences of population structure for sex allocation and sexual conflict
Authors: Rodrigues Leonor R. , Sáez Mario Torralba , Alpedrinha João , Lefèvre Sophie , Brengues Muriel , Magalhães Sara , Duncan Alison B. 
Published: April 2020

AbstractBoth sex allocation and sexual conflict can be modulated by spatial structure. However, how the interplay between the type of dispersal and the scale of competition simultaneously affects these traits in sub-divided populations is rarely considered.We investigated sex allocation and sexual conflict evolution in meta-populations of the spider miteTetranychus urticaeevolving under budding (pairing females from the same patch) or random (pairing females from different patches) dispersal and either local (fixed sampling from each subpopulation)versusglobal (sampling as a function of subpopulation productivity) competition.Females evolving under budding dispersal produced less female-biased offspring sex ratios than those from the random dispersal selection regimes, contradicting theoretical predictions. In turn, the scale of competition did not have a strong effect on sex allocation. Males evolved under budding dispersal induced less female harm than those exposed to random dispersal, but there was no reduction in female fitness following exposure to multiple mates from either selection regime.This work highlights that population structure can impact the evolution of sex allocation and sexual conflict. We also discuss how selection on either trait may reciprocally affect the evolution of the other, for example via effects on fecundity.
Positional deviation detection of silicone caps on FPCB
Authors: Li Dejian , Li Shaoli , Yuan Weiqi 
Published: April 2020

Purpose
The purpose of this paper is to propose a defect detection method of silicone caps positional deviation on flexible printed circuit board (FPCB) of keyboard based on automatic optical inspection.

Design/methodology/approach
First, the center of silicone caps of target keyboard FPCB image was extracted as feature points for generating the feature image which is used for registration rigidly with the reference feature image generated from the CAD drawings. Then, a flexible image registration method based on the surrounding-control-center B-splines (SCCB) strategy was proposed, which could correct the flexible deformation of the image generated by FPCB substrate while keeping the pasting deviation information about silicone caps unchanged. Finally, on this basis, a nearest neighbor strategy was proposed to detect the positional deviation of silicone caps.

Findings
Experimental results show that the proposed method can effectively detect the positional deviation defect of silicone caps. The G-mean value of the proposed method is 0.941746, which is 0.3 higher compared to that of similar research.

Originality/value
This paper presents a method to detect positional deviation defect of silicone caps on keyboard FPCB. Different from the classic B-spline image registration method, the proposed SCCB method used the neighborhood information of the pixel to be registered selectively to calculate the displacement vector needed for its registration, which overcame the problem that the silicone cap pasting deviation information disappears with the correction of the flexible deformation of the image.
An ultra-thin, dual band, Sub 6 GHz, 5G and WLAN antenna for next generation laptop computers
Authors: Kulkarni Jayshri Sharad 
Published: April 2020

Purpose
The purpose of this manuscript is to present a novel, compact and ultra-thin “3”-shaped monopole antenna for wireless operations in the laptop computer. The thickness of the antenna is only 0.2 mm and is designed using only a pure copper strip of size 17.5 × 6 mm2.

Design/methodology/approach
The simple structure of the proposed antenna consists of two monopole radiating strips, namely, AC and CD and an open-ended rectangular tuning stub BE of length 9mm.

Findings
This structure inspires two resonating modes at 3.45 and 5.5 GHz and achieves the measured impedance band width as 20% (3.21-3.91) GHz in lower band (F_l) and 15% (5.05-5.85) GHz in the upper band (F_u) for voltage standing wave ratio < 2. These two bands cover 5GHz wireless local area network (WLAN) and 3.3-3.6GHz (sub 6GHz) 5G bands. The measured radiation performance including, nearly omnidirectional radiation patterns, a stable gain of around 5 dBi and excellent efficiency around 90% in both operating bands have been achieved. Furthermore, a simplified equivalent circuit model has been derived and its simulation is performed. The simulated and measured results are in good agreement, which demonstrates the applicability of the antenna structure for WiMAX/WLAN operations in the prominent ultra-thin laptop computers.

Originality/value
The proposed antenna is designed without using any reactive elements, vias or matching circuits for excitation of WLAN and 5G bands in the laptop computers. The design also does not require any additional ground for mounting the antenna. The proposed antenna has a very low profile, is ultra-thin, cost-effective, easy to manufacture and can be easily embedded inside next generation laptop computers.