bluuebunny/crossref_metadata_2025_split huggingface dataset:
The spatial evolution of young massive clusters
Authors: Buckner Anne S. M. , Khorrami Zeinab , González Marta , Lumsden Stuart L. , Moraux Estelle , Oudmaijer René D. , Clark Paul , Joncour Isabelle , Blanco José Manuel , de la Calle Ignacio , Hacar Álvaro , Herrera-Fernandez José M. , Motte Frédérique , Salgado Jesús , Valero-Martín Luis 
Published: March 2020

Context. Better understanding of star formation in clusters with high-mass stars requires rigorous dynamical and spatial analyses of star-forming regions.
Aims. We seek to demonstrate that “INDICATE” is a powerful spatial analysis tool which when combined with kinematic data from Gaia DR2 can be used to probe star formation history in a robust way.
Methods. We compared the dynamic and spatial distributions of young stellar objects (YSOs) at various evolutionary stages in NGC 2264 using Gaia DR2 proper motion data and INDICATE.
Results. The dynamic and spatial behaviours of YSOs at different evolutionary stages are distinct. Dynamically, Class II YSOs predominately have non-random trajectories that are consistent with known substructures, whereas Class III YSOs have random trajectories with no clear expansion or contraction patterns. Spatially, there is a correlation between the evolutionary stage and source concentration: 69.4% of Class 0/I, 27.9% of Class II, and 7.7% of Class III objects are found to be clustered. The proportion of YSOs clustered with objects of the same class also follows this trend. Class 0/I objects are both found to be more tightly clustered with the general populous/objects of the same class than Class IIs and IIIs by a factor of 1.2/4.1 and 1.9/6.6, respectively. An exception to these findings is within 0.05° of S Mon where Class III objects mimic the behaviours of Class II sources across the wider cluster region. Our results suggest (i) current YSOs distributions are a result of dynamical evolution, (ii) prolonged star formation has been occurring sequentially, and (iii) stellar feedback from S Mon is causing YSOs to appear as more evolved sources.
Conclusions. Designed to provide a quantitative measure of clustering behaviours, INDICATE is a powerful tool with which to perform rigorous spatial analyses. Our findings are consistent with what is known about NGC 2264, effectively demonstrating that when combined with kinematic data from Gaia DR2 INDICATE can be used to study the star formation history of a cluster in a robust way.
Fasciola hepatica: the dispersal of cercariae shed by the snail Galba truncatula
Authors: Rondelaud Daniel , Vignoles Philippe , Dreyfuss Gilles 
Published: March 2020

Field investigations in 14 wild watercress beds located in the French region of Limousin, a known endemic area for distomatosis, were performed for three years to determine the distance that cercariae of Fasciola hepatica can reach in water before their encystment on the host plant. Each bed was located on the course of an open drainage furrow, while snails (Galba truncatula) lived upstream around the emergence of a source. Five plant species were collected in early April and examined to find metacercariae. Most cysts were noted on Nasturtium officinale (188 on 48.7 kg of dripped plants), followed by Helosciadium nodiflorum (125 on 33.4 kg). On the other plant species, there were few larvae. Most cercariae encysted on the plants growing in the most upstream part of each bed, usually on the first 50 cm in length. When water in the beds was fast running, the distribution of metacercariae was more limited and their number was fewer than those in the beds fed by a slow flow of water. Cercariae were able to swim or were carried away by the current up to a mean of 5 m in slow-flow waters before encysting; this distance was only 4 m in faster waters. Plants growing on the most upstream section of a watercress bed located in a drainage furrow are the most used by cercariae for their encystment, when snails live around the emergence of a source. The speed of the water current affected the number and distribution of metacercariae in the bed.
Prophylaxe und Therapie des atherothrombotischen Schlaganfalls
Authors: Mengel Annerose , Ziemann Ulf 
Published: March 2020

ZUSAMMENFASSUNGDerzeit wird die Therapiestrategie bei Patienten mit ACI-Stenose noch hauptsächlich durch den Stenosegrad und rezent (< 6 Monate) stattgehabter ipsilateraler TIA/zerebraler Ischämie beurteilt. Es liegen allerdings zahlreiche Studien vor, dass anhand bildgebender Biomarker stenosierende und nicht stenosierende Plaques identifiziert werden können, welche mit erhöhtem Schlaganfallrisiko einhergehen. Unter Berücksichtigung dieser Biomarker ist eine verbesserte Selektion von Patienten für medikamentöse und interventionelle Therapieverfahren voraussichtlich möglich. Konservative Therapiemaßnahmen sollten neben der Thrombozytenfunktionshemmung eine lipidsenkende Statintherapie, welche nicht nur die Plaqueprogression verhindert, sondern auch die Plaquestabilität verbessert, sowie eine leitliniengerechte Einstellung aller kardiovaskulären Risikofaktoren umfassen.Der Zusatznutzen von CEA (carotid endarterectomy) oder CAS (carotid artery stenting) gegenüber einer intensivierten medikamentösen Therapie bei Patienten mit geringem bis moderatem Schlaganfallrisiko 30 und symptomatischer bzw. asymptomatischer ACI-Stenose ist derzeit unklar. Diese Patientengruppe wird seit 2015 durch das ECST-2-Trial (ISRCTN97744893) prospektiv randomisiert untersucht. Erste Ergebnisse werden in diesem Jahr erwartet. Ebenfalls erwarten wir mit Spannung die überarbeitete S3-Leitlinie Karotisstenose, welche vor allem bei asymptomatischer ACI-Stenose anhand der beschriebenen zusätzlichen klinischen und bildmorphologischen Kriterien eine differenziertere Behandlung eröffnen wird.
Diabetische Ketoazidose
Authors: Meyhöfer Svenja , Serfling Georg , Schmid Sebastian M. 
Published: March 2020

ZUSAMMENFASSUNGDie diabetische Ketoazidose (DKA) ist eine schwerwiegende metabolische Komplikation des Diabetes, die auf einen absoluten Insulinmangel zurückzuführen ist. Die Hyperglykämie, die metabolische Azidose und die Zunahme von zirkulierenden Ketonkörpern im Blut kennzeichnen eine DKA. Typische Auslöser sind meist eine fehlende Insulinzufuhr oder Zustände eines gesteigerten Insulinbedarfs. Zudem ist mittlerweile bekannt, dass auch Patienten mit einem Typ-2-Diabetes unter einer Therapie mit SGLT-2-Inhibitoren eine DKA erleiden können, auch ohne ausgeprägte Hyperglykämie. Moderne Krebstherapien mit Immun-Checkpoint-Inhibitoren tragen das Risiko eines immunvermittelten Diabetes, der oftmals im Rahmen einer DKA erstdiagnostiziert wird. Nicht nur die DKA an sich stellt eine lebensbedrohliche Situation dar – auch eine zu strenge oder inadäquate Behandlung der DKA kann lebensbedrohliche Komplikationen mit sich tragen. Bei zu schneller Blutzuckersenkung kann ein zerebrales Ödem auftreten. Insgesamt scheint die Prävalenz einer DKA in den letzten Jahren gestiegen zu sein. Die steigende Prävalenz sowie die diagnostischen und therapeutischen Herausforderungen machen die dringende Notwendigkeit für eindeutig definierte Strategien bei Diagnose und Behandlung für eine bessere Umsetzung deutlich.
Akutkomplikationen bei Typ-1-Diabetes im Kindes- und Jugendalter
Authors: Reschke Felix , Kordonouri Olga 
Published: March 2020

ZUSAMMENFASSUNGDie Diagnose eines Typ 1 Diabetes mellitus stellt – trotz großer technischer und pharmakologischer Errungenschaften in der letzten Dekade – weiterhin eine sehr große Belastung für Patient, Angehörige und familiäres Umfeld dar. Neben der Diskussion hinsichtlich der optimalen Therapieführung, und Verringerung bzw. Vermeidung von Folgeschäden der Erkrankung, sind potenziell auftretende Akutkomplikationen, sowohl hypo- als auch hyperglykämischer Art, eine alltägliche Herausforderung für die Patienten. Trotz der sukzessiven Abnahme der Anzahl an diabetischen Ketoazidosen bei bekanntem Diabetes und schweren Hypoglykämien in den letzten Jahren, stellt – insbesondere im Kleinkindalter – die diabetische Ketoazidose im Rahmen der Diabetesmanifestation weiterhin ein ungelöstes Problem dar.
Prevalence of Musculoskeletal Complaints of Arm, Neck and Shoulder and Associated Risk Factors in Computer Office Workers
Authors: Kashif Muhammad , Anwar Mariam , Noor Hafsa , Iram Humaira , Hassan Hafiz Muhammad Junaid 
Published: March 2020

AbstractBackground The musculoskeletal complaints of the arm, neck and/or shoulder (CANS) affect the work-related tasks of workers who are sitting in front of the computer for an extended period of time and therefore lead to a reduction in productivity. The purpose of this study was to determine the prevalence of CANS and associated risk factors among computer office worker.Methodology A cross-sectional study was conducted among 773 computer workers working in different work settings located in Faisalabad Pakistan from January to August 2019. The questionnaires adopted in this survey study were previously used and consist of 2 parts; the first section for demographic information and the second part consists of the the Masstricht Upper Extremity Questionnaire (MUEQ) that was used to determine the prevalence of CANS.Results Of the 773 participants, 327 (42%) had shoulder pain, followed by neck pain 270 (35%), and the prevalence of pain in the upper arm and lower arm was 129 (17%) and 80 (10%), respectively. Those absent due to musculoskeletal problems were only 80 (10%). Females have reported overall more complaints 65% in upper extremity during the past years than male i. e. 56%. The study showed that there was a significant relationship between pain and age (years) (P=0.024), pain and work posture (P<0.001), and pain and work setting (P=0.009).Conclusion The study concluded that CANs are prevalent in office workers, predominantly among women, and that risk factors closely related to CANS are age, work setting and sitting posture.
Extinguishing Febrile Infection-Related Epilepsy Syndrome: Pipe Dream or Reality?
Authors: Payne Eric T. , Koh Sookyong , Wirrell Elaine C. 
Published: March 2020

AbstractFebrile infection-related epilepsy syndrome (FIRES) is a rare and devastating epileptic encephalopathy with historically abysmal neurocognitive outcomes, including a high incidence of mortality. It tends to affect children and young adults and is characterized by superrefractory status epilepticus following a recent febrile illness. Growing evidence suggests a heterogeneous etiology resulting in fulminant nonantibody-mediated neuroinflammation. For some children with FIRES, this aberrant neuroinflammation appears secondary to a functional deficiency in the endogenous interleukin-1 receptor antagonist. A precise etiology has not been identified in all FIRES patients, and current treatments are not always successful. Limited treatment evidence exists to guide choice, dosing, and duration of therapies. However, the ketogenic diet and certain targeted immunomodulatory treatments, including anakinra, appear safe and have been associated with relatively excellent clinical outcomes in some FIRES patients. Future prospective multicenter collaborative studies are needed to further delineate the FIRES heterogeneous disease pathophysiology and to determine the safety and efficacy of treatment strategies through a robust measurement of neurocognitive outcomes.
Ready for global success? Strengths and weaknesses of Korean HRM
Authors: Froese Fabian Jintae 
Published: March 2020

AbstractFueled by a highly dedicated and highly skilled workforce, South Korea (henceforth Korea) has enjoyed tremendous economic growth and developed numerous successful global companies. In the past, Korean companies benchmarked Japanese and US HR practices. However, Korean companies are now at the crossroads, facing slowing economic growth rates, an aging population, changing gender roles, and an increase in foreign employees. This article reviews the strengths and weaknesses of Korean HRM and presents some tentative recommendations how Korean companies can respond to these challenges. If Korean companies intend to continue their global success, they are recommended to adapt their staffing strategy, organizational culture, and corporate language policies to embrace an increasingly diverse workforce.
Pharmacy On-Site Overdose Protocols and Prevention of Overdose
Authors: Green Traci C. , Soipe Ayorinde , Baloy Brianna , Burstein Dina , Xuan Ziming , Tapper Abigail , Walley Alexander Y. , Case Patricia , Bratberg Jeffrey , Baird Janette 
Published: March 2020

Background Opioid overdose is a preventable injury leading to high morbidity and premature mortality in communities across the United States. Overdoses take place where people use drugs, including commercial and public locations like community pharmacies, and necessitate swift detection and response to avoid harm and, even more seriously, death. The presence of emergency and safety protocols improves occupational health and safety for all in the workplace. The aim of this study was to assess the prevalence of experience with on-site pharmacy overdose and to explore pharmacist and site characteristics associated with having a known protocol for responding to on-site overdose emergencies. Methods An anonymous, online survey about naloxone provision and opioid safety was delivered by email, through professional pharmacy associations and continuing education attendance lists, to 3,100 pharmacists in Massachusetts and Rhode Island between October 2017 and January 2018. Survey items gauged socio-demographics, practice site characteristics, safer opioid dispensing and naloxone provision. Summary statistics and bivariate analyses were conducted to describe characteristics associated with items pertaining to on-site overdose policy awareness. Results Of the 357 respondents (11.5% response rate), 154 (5.0%) answered the questions of interest: 17.5% reported having at least one suspected overdose on-site at their practice location, while 42.9% reported that they were knowledgeable about and could locate at their practice location an on-site overdose protocol detailing how to respond to an overdose. Pharmacists who were knowledgeable about protocols were also more likely to offer naloxone to patients ( p = 0.02) and did not practice at a chain pharmacy ( p = 0.01). Conclusions Community pharmacies that stock and distribute naloxone are key parts of community efforts to address the opioid crisis. Pharmacies and other healthcare settings should develop and implement on-site overdose response protocols and cultivate a norm of naloxone provision to patients.
Single GaAs nanowire based photodetector fabricated by dielectrophoresis
Authors: García Núñez Carlos , Braña Alejandro F , López Nair , Pau José L , García Basilio J 
Published: March 2020

Abstract
Mechanical manipulation of nanowires (NWs) for their integration in electronics is still problematic because of their reduced dimensions, risking to produce mechanical damage to the NW structure and electronic properties during the assembly process. In this regard, contactless NW manipulation based methods using non-uniform electric fields, like dielectrophoresis (DEP) are usually much softer than mechanical methods, offering a less destructive alternative for integrating nanostructures in electronic devices. Here, we report a feasible and reproducible dielectrophoretic method to assemble single GaAs NWs (with radius 35–50 nm, and lengths 3–5 μm) on conductive electrodes layout with assembly yields above 90% per site, and alignment yields of 95%. The electrical characteristics of the dielectrophoretic contact formed between a GaAs NW and conductive electrodes have been measured, observing Schottky barrier like contacts. Our results also show the fast fabrication of diodes with rectifying characteristics due to the formation of a low-resistance contact between the Ga catalytic droplet at the tip of the NW when using Al doped ZnO as electrode. The current-voltage characteristics of a single Ga-terminated GaAs NW measured in dark and under illumination exhibit a strong sensitivity to visible light under forward bias conditions (around two orders of magnitude), mainly produced by a change on the series resistance of the device.
The Effect of Plectranthus amboinicus Lour Spreng Ethanolic Extract on Relative Organ, Body Weights Changes, and Hematology Profile in Wistar Rats Treated with 7,12Dimethylbenz(a)anthracene
Authors: Silitonga M , Gultom E S , Nugrahalia M 
Published: March 2020

Abstract
This study aims to examine the protective properties of ethanol extract Plectranthus amboinicus (EEP) leaves on body weight gain, the relative weight of liver, kidney, lung, spleen, thymus and haematological profile of rats induced by 7,12Dimethylbenz(a)anthracene (DMBA). Used 25 female rats, divided into five groups namely NC (given Carboxymethyl cellulose (CMC) 1%), PC (given DMBA 20 mg/kg body weight), T1, T2, and T3 were each given DMBA 20 mg/kg body weight once every four days for 32 days and EEP 175, 350, and 700 mg/kg body weight given every day from day 33 to 59. Both the DMBA and EEP are given orally using a gastric gavage. On day 60, rats were killed by neck dislocation, bood collected in EDTA tubes for hematological analysis, rats are dissected to obtain liver, kidney, lung, thymus, and spleen organs. Data were analyzed with one way Analisys of varians (ANOVA). The results of this study indicate that EEP in T1, T2 and T3 treatments has no effect on weight loss compared to PC. There was no effect of EEP on the relative weight of the liver, kidneys, spleen, thymus and lungs. EEP increased the number of erythrocytes, leukocytes and platelets in rats that had DMBA
Hepatoprotective effects of beetroot juice at maximum physical activity
Authors: Sinaga F A , Hasibuan R , Risfandi M , Sinaga R N 
Published: March 2020

Abstract
The purpose of this study was to determine the protective effects of beetroot juice treatment on hepatic oxidative stress at maximum physical activity. This type of research is an experimental study with a randomized control group pretest-posttest design research. The study was conducted at the Universitas Negeri Medan Stadium and Universitas Sumatera Utara Faculty of Medicine Laboratory. The sample was 30 students of Sports Science who met the criteria. The Pretest is done by checking the levels of alanine aminotransferase, aspartate aminotransferase, and malondialdehyde. Furthermore the sample was divided into 2 groups (P1 = 15, P2 = 15). During the 30-day training program, the P1 group was given 250 ml beetroot juice once a day, whereas P2 was given as a control. Then all samples performed a maximal physical activity using a bleep test, and again examined levels of alanine aminotransferase, aspartate aminotransferase, and malondialdehyde. The results showed beetroot juice could reduce levels of malondialdehyde, alanine transaminase, and aspartate transaminase at maximum physical activity.
Effect of Mangosteen Peel Supplementation on Erythrocytes and Hemoglobin in Male Students after Heavy Physical Exercise
Authors: Sinaga R N , Zulaini  , Jumadin IP 
Published: March 2020

Abstract
Oxidative stress due to heavy physical exercise can cause damage to the cell body of one of several erythrocytes and hemoglobin. Natural antioxidant consumption is a way to overcome the effect of oxidative stress. One of the natural antioxidants is mangosteen peel with high content of antioxidants. The aim of this study is to understand the effect of mangosteen peels on erythrocytes and hemoglobin in male students after heavy physical exercise. This is a true experimental study with a pretest-posttest control group design with 21 male students which were divided into two groups. The first group was given placebo while the other groups were given mangosteen peels supplementation with dosage of 550 mg for two weeks. Physical exercise with an intensity of 75%-85% using a treadmill is done three times a week for all groups. Erythrocytes and hemoglobin were measured before and after treatment. Erythrocytes levels decreased significantly in the control group and increased insignificantly in the treatment group. Hemoglobin levels decreased significantly in the control group and increased significantly in the treatment group. From this study, it can be concluded that mangosteen peel supplementation acts as antioxidant to erythrocytes and hemoglobin in male students after heavy physical exercise.
A New Record Mycoheterotrophic Plant in Bukit Barisan Grand Forest Park, North Sumatra, Indonesia
Authors: Handayani D , Rezeqi S , Sari W D P , Ritonga Y E , Prakasa H 
Published: March 2020

Abstract
Mycoheterotrophic plants are unique plants because these plants do not have leaves (chlorophyll) and get their nutrients from a symbiotic relationship with fungi. In some recent literature, Mycoheterotrophic can be also called holomycotrophic plants. The purpose of this study was to determine the mycoheterotrophic plant species in the Bukit Barisan Grand Forest Park, North Sumatra. The purpose of this research is to know the type of mycoheterotrophic plant in Bukit Barisan Grand Forest Park, North Sumatra, Indonesia. This research was conducted in August 2019 in Bukit Barisan Grand Forest Park, North Sumatra, Indonesia. In conducting plant sampling the method used is the exploration or roaming method. Identification of mycoheterotrophic plants based on morphological characteristics in the form of habitus, stems, flowers, roots and matched using literature then lists the species of mycoheterotrophic plants presented in this study consisting of scientific names, synonyms, descriptions, distributions, ecological information. The results of field exploration found 3 species in two mycoheterotrophic plant families, Burmaniaceae and Orchidaceae. The Burmaniaceae family consists of 1 type of Burmannia lutescens Becc. While the Orchidaceae family consists of two species, among others, the Epipogium roseum (D. Don) Lindl. and Gastrodia siamensis Rolfe ex Downie. 3 mycoheterotrophic plants became a new record for the Forest Park of Bukit Barisan Sumatra Utara because previously there was no data on the plant.
The Development Of Best Practice Handbook Learning Strategy Based On Flip Book To Support Blended Learning Processes
Authors: Simatupang H , Purnama D , Simatupang Z 
Published: March 2020

Abstract
This research aims to: 1) Produce teaching material best practice handbook by implementing the use of Flipbook application as a teaching and learning strategy, validated in the viewpoints of material and learning design; 2) To investigate the effectiveness of using best practice handbook as a teaching material with the implementation of Flipbook application as a teaching and learning strategy. The sample of this study includes Universitas Negeri Medan biology students 2019/2020 in their odd semester currently taking teaching and learning strategy course. The type of Research and Development research is a developed model using ADDIE (Analysis, Design, Development, Implementation, and Evaluation). The results of this study indicate that the value of eligibility by material acquisition experts is 86.21% that very decent criteria and the feasibility value by learning experts is 82.5% that feasible criteria. The effectiveness of teaching materials test was obtained 62.4% that adequately effective category. It can be concluded that the development of teaching materials for handbook best practice using Flipbook strategy course applications is suitable to use in teaching and learning strategies.