bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advances in Ovonic Threshold Switch Selector Technologies for Storage Class Memory: From Fundamentals to Development and Beyond
Authors: Ban Sanghyun , Lee Jangseop , Seo Yoori , Lee Wootae , Kim Taehoon , Hwang Hyunsang 
Published: December 2024

AbstractThe explosive increase in the demand for data driven by advancements in artificial intelligence technology and rapid expansion of data centers necessitates storage class memory (SCM) capable of alleviating data traffic and workload issues. The success of SCM depends heavily on the selector. The ovonic threshold switch (OTS), a chalcogenide‐based amorphous thin film, has garnered increasing attention as a selector owing to its suitable characteristics. Here, OTS devices based on various chalcogens (tellurium, selenium, and sulfur) are reviewed, and how the selection of a chalcogen should be dictated by the specific requirements of the application is highlighted, because the OTS characteristics vary significantly depending on the choice. Additionally, OTS characteristic engineering from multiple perspectives, including material engineering via elemental doping, electrode engineering, physical property engineering via post‐treatment, and structural/interface engineering using multiple layers is reviewed. Finally, selector‐only memory (SOM) is examined, which offers better scalability and performance than the existing one‐memory and one‐selector structure, which combines an OTS with phase‐change memory. Moreover, a cost‐effective 3D vertical X‐point memory is also discussed, emphasizing that its ultimate implementation should be achieved using an SOM. Thus, insights and guidelines for OTS material design, stack engineering, and cell parameter design are provided here.
Deep DeePC: Data‐enabled predictive control with low or no online optimization using deep learning
Authors: Zhang Xuewen , Zhang Kaixiang , Li Zhaojian , Yin Xunyuan 
Published: December 2024

AbstractData‐enabled predictive control (DeePC) is a data‐driven control algorithm that utilizes data matrices to form a non‐parametric representation of the underlying system, predicting future behaviors and generating optimal control actions. DeePC typically requires solving an online optimization problem, the complexity of which is heavily influenced by the amount of data used, potentially leading to expensive online computation. In this article, we leverage deep learning to propose a highly computationally efficient DeePC approach for general nonlinear processes, referred to as Deep DeePC. Specifically, a deep neural network is employed to learn the DeePC vector operator, which is an essential component of the non‐parametric representation of DeePC. This neural network is trained offline using historical open‐loop input and output data of the nonlinear process. With the trained neural network, the Deep DeePC framework is formed for online control implementation. At each sampling instant, this neural network directly outputs the DeePC operator, eliminating the need for online optimization as conventional DeePC. The optimal control action is obtained based on the DeePC operator updated by the trained neural network. To address constrained scenarios, a constraint handling scheme is further proposed and integrated with the Deep DeePC to handle hard constraints during online implementation. The efficacy and superiority of the proposed Deep DeePC approach are demonstrated using two benchmark process examples.
Associations of maternal peripregnancy cannabis use with behavioral and developmental outcomes in children with and without symptoms of autism spectrum disorder: Study to Explore Early Development
Authors: DiGuiseppi Carolyn , Crume Tessa , Holst Brady , Aiona Kaylynn , Van Dyke Julia , Croen Lisa A. , Daniels Julie L. , Friedman Sandra , Sabourin Katherine R. , Schieve Laura A. , Wiggins Lisa , Windham Gayle C. , Robinson Rosenberg Cordelia 
Published: December 2024

AbstractSome studies report increased prevalence of autism spectrum disorder (ASD) and associated symptoms with prenatal cannabis exposure. We examined whether associations of maternal cannabis use from 3 months preconception through delivery (“peripregnancy”) with behavior and development in the offspring varied with the presence of ASD symptoms. Children ages 30–68 months with ASD symptoms (i.e., met study criteria for ASD or had ASD symptoms on standardized assessments or community ASD diagnosis, N = 2734) and without ASD symptoms (other developmental delay/disorders or general population sample, N = 3454) were evaluated with the Child Behavior Checklist and Mullen Scales of Early Learning. We examined cannabis use during three time periods: peripregnancy, pregnancy, and only preconception. Peripregnancy cannabis exposure was reported for 6.0% of children with and 4.6% of children without ASD symptoms. Preconception‐only cannabis use (versus no use) was associated with more aggressive behavior, emotional reactivity, and sleep problems in children with ASD symptoms, but not in children without ASD symptoms. Cannabis use during pregnancy was associated with increased attention and sleep problems in children with ASD symptoms; these associations did not differ significantly by ASD symptoms. Peripregnancy cannabis use was not associated with child developmental abilities regardless of ASD symptoms. In summary, associations of peripregnancy cannabis use with some behavioral outcomes differed in children with and without ASD symptoms. With rising cannabis use among pregnant women, future studies that examine a range of developmental risks associated with timing and patterns of cannabis use prior to conception as well as during pregnancy could inform clinical guidance.
Fluorescent Reporter‐Based Fiber Optic Probe for Continuous Detection of Antibodies
Authors: Nandy Suman , Vu Binh V. , Maranholkar Vijay M. , Goyal Atul , Kourentzi Katerina , Willson Richard C. 
Published: December 2024

ABSTRACTMeasurement of antibody and antibody fusion protein concentration is vital for process development and manufacturing. Continuous, in‐line monitoring of antibody concentration could be useful in a variety of applications, such as controlling the loading of protein A columns to prevent breakthrough, monitoring bioreactor titer, and detecting leaks past ultrafiltration/diafiltration membranes. Molecule‐specific monitoring techniques are advantageous for antibody detection in cell culture fluid in the presence of complex process impurities. Here we report a continuous in‐line, real‐time IgG monitoring platform using a fiber‐optic biosensor with a replaceable sensor tip covalently functionalized with a fluor‐labeled protein consisting of a pentamer of the Z domain (a more stable form of the B domain) of protein A. The sensor demonstrates concentration‐dependent fluorescence enhancement in the presence of human IgG (0.01–0.75 g/L), with consistent signals during five runs each with 1 and 0.1 g/L IgG, and maintains its specificity in the presence of Chinese hamster ovary (CHO) cell culture fluid. A 5% breakthrough of a typical 10 g/L load would be detected in less than 20 s in a flowing stream emerging from a protein A column without prior sample preparation. This sensor platform may be suitable for monitoring IgG and fragment, crystallizable (Fc) fusion proteins in diverse upstream and downstream bioprocess applications.
Does Empowerment of National Minorities Through Sustainable Ethnic Tourism Overcome Prejudices? Lessons From Serbia
Authors: Gajić Tamara , Veljović Sonja , Petrović Marko D. , Radovanović Milan M. , Kholina Veronika N. , Dávid Lóránt Dénes 
Published: December 2024

ABSTRACTThis study analyses the perceptions and attitudes of national minorities in Serbia towards the impact of ethnic tourism on the preservation of their cultural identity, economic benefits, the reduction of prejudices and the future development of ethnic‐tourism. Using a qualitative approach, semi‐structured interviews were conducted with members of different national minorities: Slovaks, Hungarians, Bosniaks, Ruthenians, Vlachs and Roma. Thematic analysis was used to identify key issues and gain insights into the views of the interviewees. The results show that ethnic tourism contributes significantly to the economic development of these communities by creating jobs and supporting local businesses. Ethnic tourism also plays a key role in the preservation and promotion of cultural heritage through festivals, traditional crafts and gastronomy. Interaction with tourists helps to break down stereotypes and prejudices and promotes mutual understanding and tolerance. However, challenges are also recognised, such as the commercialization of culture and the need for sustainable practices. The importance of this research for Serbia is particularly great, as it is a country with numerous national minorities and the potential for the development of ethnic tourism. Serbia faces prejudices and stereotypes, and ethnic tourism can play a key role in reducing these prejudices and promoting cultural diversity. The results of this research can inform managers and development professionals on how to integrate sustainable practices and cultural identity into tourism strategies and thus promote the long‐term prosperity of national minorities in Serbia.
Navigating The Deuteration Landscape: Innovations, Challenges, and Clinical Potential of Deuterioindoles
Authors: Zhang Li , Zhang Shujingwei , Zhang Yang , Liu Bo , Li Xiang , Han Bo 
Published: December 2024

AbstractIndoles, pivotal to the realm of drug discovery, underpin numerous FDA‐approved therapeutics. Despite their clinical benefits, pharmacokinetic and toxicity concerns have occasionally hampered their broader application. A notable advancement in this domain is the substitution of hydrogen atoms with deuterium, known as deuterium modification, which significantly enhances the pharmacological properties of these compounds. This review elucidates the progression of deuterium chemistry, culminating in approval of Deutetrabenazine in 2017. This milestone has catalyzed additional research into deuterated indoles, such as Dosimertinib, which have demonstrated enhancements in stability, toxicity profiles, and therapeutic efficacy. Moreover, the review addresses challenges and patent issues in the synthesis of deuterated indoles and highlights their potential applications in precision medicine. In the future, deuterated indoles may positively impact therapy and contribute to advances in precision medicine through molecular engineering.
Multimodal Imaging of Coronary Bifurcation TAP Procedures Utilizing Visible Heart® Methodologies: EBC Recommended Steps and Bailout Procedures
Authors: Stankovic Goran , Cangemi Stefano , DeVos Amanda , Burzotta Francesco , Iaizzo Paul A. 
Published: December 2024

ABSTRACTIn some cases it is critical to clinically perform coronary bifurcation stenting to minimize the potential risk for restenosis and/or stent thrombosis. The European Bifurcation Club (EBC) has provided guidelines for optimally performing such procedures. Yet, sometimes such procedures do not go as planned, and in some cases bailout procedures are required. Here we utilized Visible Heart® (VH) methodologies and multimodal visualizations to better understand each step for optimally performed T and small protrusion (TAP) procedures, as well as those in which complications occurred. These studies were performed within reanimated swine hearts in which endoscopes, fluoroscopy, and optical coherence tomography (OCT) could readily be used. Additionally, because these procedures were performed in reanimated hearts, one could intentionally cause complications, so to perform bailout procedures. Finally, following these procedures each specimen was micro CT scanned, and high resolution computational models (~40 microns) were reconstructed of the final outcomes.
Comparison of Multivessel Versus Culprit‐Vessel‐Only Revascularization in Patients With STEMI and Multivessel Disease During Primary PCI: In‐Hospital Outcomes From the CCC‐ACS Project in China
Authors: Zhao Tinghao , Wang Jun , Gu Ruoxi , Sun Dongyuan , Zheng Lingfei , Tian Xiaoxiang , Han Yaling , Wang Xiaozeng ,   CCC‐ACS investigators
Published: December 2024

ABSTRACTBackgroundThe consensus on whether acute ST‐segment elevation myocardial infarction (STEMI) patients with multivessel coronary artery disease (MVD) benefit from complete revascularization during primary percutaneous coronary intervention (PCI) is unclear.AimsThis study aims to assess the impact of multivessel PCI (MV‐PCI) versus culprit‐vessel‐only PCI (CV‐PCI) on in‐hospital outcomes in a Chinese population.MethodsWe evaluated STEMI patients with MVD undergoing PCI, registered in the Improving Care for Cardiovascular Disease in China‐Acute Coronary Syndrome (CCC‐ACS) project, from November 2014 to December 2019. Using inverse probability of treatment weighting (IPTW) and multivariable Cox regression, we compared the incidence of in‐hospital Major Adverse Cardiac Events (MACE) and other adverse clinical outcomes between the MV‐PCI and CV‐PCI groups.ResultsAmong 8138 patients included, 840 (10.3%) underwent MV‐PCI, and 7298 (89.7%) underwent CV‐PCI. MV‐PCI was associated with higher in‐hospital MACE (2.0% vs. 0.9%, p = 0.005), all‐cause mortality (1.7% vs. 0.7%, p = 0.003), and contrast‐induced acute kidney injury (CI‐AKI) (13.6% vs. 10.2%, p = 0.002), after IPTW adjustment. The multivariable Cox analysis further validated the increased risks associated with MV‐PCI.ConclusionIn the Chinese STEMI population with MVD, participating in the CCC‐ACS project, MV‐PCI during primary PCI was linked to higher in‐hospital adverse events compared to CV‐PCI. These findings advocate for a cautious approach to MV‐PCI in this setting, suggesting a potential preference for a staged PCI strategy for nonculprit vessels.Trial RegistrationThe information of clinical trial registration for CCC‐ACS project can be found at http://clinicaltrials.gov/study/NCT02306616
Adverse Events and Failure Modes Related to Impella RP/RP Flex: Insights From FDA MAUDE Database
Authors: Chitturi Kalyan R. , Wallace Ryan , Lorente‐Ros Marta , Merdler Ilan , Chaturvedi Abhishek , Case Brian C. , Hashim Hayder D. , Ben‐Dor Itsik , Rogers Toby , Waksman Ron 
Published: December 2024

ABSTRACTBackgroundImpella RP and RP Flex can provide right ventricular (RV) support in numerous clinical situations. Notably, the redesigned RP Flex allows for an internal jugular approach compared to the femoral venous approach with RP.AimsWe investigated the type and frequency of device‐related complications as reported in the US Food and Drug Administration (FDA) Manufacturer and User Facility Experience (MAUDE) for both Impella RP and RP Flex to see if there are any differences.MethodsThe MAUDE database was accessed from January 1, 2019 to April 30, 2024, yielding 206 reports pertaining to Impella RP and 64 to RP Flex. Reports were reviewed for device indications, mode of device failure, and device‐related complications.ResultsThe most common indication for Impella RP placement was acute myocardial infarction with RV failure. The most commonly reported failure mode was pump failure. Death was reported in 8.5% and vascular complications in 3.7% of the reports. The most reported device‐related complication was hemolysis (18.5%), followed by bleeding requiring transfusion (14.1%), with new dialysis occurring in 3.3% of patients.ConclusionsOur analysis of the MAUDE database showed that device delivery issues, bleeding, and vascular complications accounted for a smaller proportion of reports with Impella RP Flex than with its predecessor. However, device‐related thrombosis and pump malfunction accounted for a higher proportion of reports with RP Flex. These data do not reflect the overall incidence of complications, but instead highlight the need for physicians and other healthcare providers to return devices to the manufacturer for inspection when a failure occurs.
Heparin Reversal for Coronary Artery Perforation
Authors: Sawayama Yuichi , Sasaki Kenta , Taninobu Narumi , Ikuta Akihiro , Osakada Kohei , Kubo Shunsuke , Tada Takeshi , Fuku Yasushi , Tanaka Hiroyuki , Nakagawa Yoshihisa , Kadota Kazushige 
Published: December 2024

ABSTRACTBackgroundReversing heparin when managing coronary artery perforation (CAP) during percutaneous coronary intervention (PCI) can provide hemostasis but may cause coronary thrombosis if a device is still present in a coronary artery.AimsTo assess the impact of heparin reversal while an intracoronary artery device is in place for CAP.MethodsThis study analyzed CAP cases during PCI from January 2006 to October 2023. Patients were grouped according to implementing heparin reversal while an intracoronary artery device was in place. The safety outcome was coronary thrombosis after CAP. The efficacy outcomes were successful hemostasis and death from any cause.ResultsCAP occurred in 368 of 22,368 cases (1.6%). Patients who had heparin reversal with a device in place comprised 211 (57%). Among these, coronary thrombosis occurred in 16 (7.6%). An activated clotting time (ACT) 〈150 seconds was significantly correlated with coronary thrombosis. Heparin reversal with a device in place was significantly associated with successful hemostasis (heparin reversal 91% vs. no heparin reversal 73%; adjusted odds ratio 2.78; 95% confidence interval 1.27−6.13; p = 0.011), but was not different for death from any cause (heparin reversal 4.3% vs. no heparin reversal 5.7%; adjusted odds ratio 0.97; 95% confidence interval 0.28−3.43; p = 0.964).ConclusionHeparin reversal with a device in place was associated with an increased risk of coronary thrombosis when ACT was less than 150 seconds. While it may not have a substantial association with a reduced risk of mortality, it offers an advantage in achieving successful hemostasis.
Site‐Specific Incorporation of Fluorinated Prolines into Proteins and Their Impact on Neighbouring Residues
Authors: Elena‐Real Carlos A. , Urbanek Annika , Sagar Amin , Mohanty Priyesh , Levy Geraldine , Morató Anna , Fournet Aurélie , Allemand Frédéric , Sibille Nathalie , Mittal Jeetain , Sinnaeve Davy , Bernadó Pau 
Published: December 2024

AbstractThe incorporation of fluorinated amino acids into proteins provides new opportunities to study biomolecular structure‐function relationships in an elegant manner. The available strategies to incorporate the majority of fluorinated amino acids are not site‐specific or imply important structural modifications. Here, we present a chemical biology approach for the site‐specific incorporation of three commercially available Cγ‐modified fluoroprolines that has been validated using a non‐pathogenic version of huntingtin exon‐1 (HttExon‐1). 19F, 1H and 15N NMR chemical shifts measured for multiple variants of HttExon‐1 indicated that the trans/cis ratio was strongly dependent on the fluoroproline variant and the sequence context. By isotopically labelling the rest of the protein, we have shown that the extent of spectroscopic perturbations to the neighbouring residues depends on the number of fluorine atoms and the stereochemistry at Cγ, as well as the isomeric form of the fluoroproline. We have rationalized these observations by means of extensive molecular dynamics simulations, indicating that the observed atomic chemical shift perturbations correlate with the distance to fluorine atoms and that the effect remains very local. These results validate the site‐specific incorporation of fluoroprolines as an excellent strategy to monitor intra‐ and intermolecular interactions in disordered proline‐rich proteins.
Selective Self‐Assembly of Supramolecular Helices and Macrocycles Directed by Halogen Bonding
Authors: Hu Zhi‐Yuan , Du Mengxin , Li Wenhao , Huang Xin , Ma Ruijie , Li Yunhan , Shen Ren‐Zeng , Wang Tao , Liu Chuan‐Zhi , Li Zhan‐Ting 
Published: December 2024

AbstractIn this study, several hydrogen‐bonded arylamide foldamers (compounds 1–5) with the same degree of polymerization were designed and synthesized. The polyfluoroiodobenzene or iodoethynyl polyfluoroiodobenzene segment was modified as a halogen donor at the end of the monomer, and pyridine or pyridine oxynitride served as the corresponding halogen acceptor segment. The crystal structure of compound 1 indicates that the supramolecular double helices were constructed by stacking a P helix and an M helix in an antiparallel manner in the direction of intermolecular I⋅⋅⋅−O−N+ halogen bonding. The zig‐zag‐shaped linear structures of compounds 2 and 3 were generated under the induction of intermolecular I⋅⋅⋅N and I⋅⋅⋅−O−N+ halogen bonds. [1+1] near‐planar bimolecular supramolecular macrocycles in compounds 4 and 5 were formed by multiple groups of effective intramolecular three‐center hydrogen bonding and strong I⋅⋅⋅N and I⋅⋅⋅−O−N+ halogen bonds. Hirshfeld surface analysis and theoretical modelling of the halogen bonding energy were performed. The noncovalent interactions on the surface of the monomers and the halogen bonding energy were investigated in detail.
Establishment and simulation study of equivalent model for thermal contact resistance in electronic devices
Authors: Xiao Weiqiang , Lu Xinbo , Teng Ruyu , Xu Qingyi , Wu Jian , Xu Jian , Han Yufeng , Zhou Guojun , Zhan Wangcheng 
Published: December 2024

AbstractTo accurately determine thermal contact resistance (TCR) for the thermal design of electronic devices, a simplified simulation method is first proposed for calculating thermal contact resistance. First, an equivalent geometric model is established based on actual rough surfaces Then, finite element methods are employed to calculate the thermal contact resistance. The results demonstrate that the proposed equivalent geometric model, containing contact point information, can accurately predict the thermal contact resistance, which has a deviation of 10% with the experimental data. Furthermore, the results revealed that both the contact pressure and the surface roughness of the materials significantly influenced TCR, through adjusting the gap thickness. As the contact pressure increased from 200 to 1400 kPa, the TCR decreased from to . The decrease became more gradual at high contact pressure, indicating a nonlinear relationship between pressure and TCR. On the other hand, the surface roughness affected TCR primarily through the equivalent contact point height, that is, the gap thickness between two samples. Moreover, temperature affected TCR mainly through radiative heat transfer, which was dependent on material intrinsic properties. The developed simplified calculation method can efficiently simulate TCR for electronic devices, which not only enhanced the understanding of TCR behaviour but also provided a practical tool for optimizing thermal designs in electronic devices.
Test of a serial mediated model of green human resource management in the manufacturing industry
Authors: Nosrati Saeid , Talebzadeh Niusha , Maydon Denitsa Hristoforova , Karatepe Osman M. 
Published: December 2024

AbstractOur paper develops and tests a serial mediated model of green human resource management (GHRM). Data came from entry‐level employees and supervisors in the power manufacturing industry in Bulgaria. The results from PROCESS Macro suggest that egoistic value, altruistic value, and biospheric value completely mediate the link between GHRM and eco‐friendly behavior (ECB). The impact of GHRM on ECB is completely mediated by environmental empathy. More importantly, egoistic value, altruistic value, or biospheric value and environmental empathy completely and serially mediate the link between GHRM and ECB. The abovementioned findings enhance the current knowledge on the mediators that operate in the association between GHRM and ECB. The results will assist policymakers, businesses, and scholars in understanding the significance of GHRM in the international marketplace as well as the underlying associations between GHRM and ECB, serving as a valuable tool for fostering and attaining these behaviors in the manufacturing industry.