bluuebunny/crossref_metadata_2025_split huggingface dataset:
PIK3CA and p53 Mutations Promote 4NQO-Initated Head and Neck Tumor Progression and Metastasis in Mice
Authors: García-Carracedo Darío , Cai Yi , Qiu Wanglong , Saeki Kiyoshi , Friedman Richard A. , Lee Andrew , Li Yinglu , Goldberg Elizabeth M. , Stratikopoulos Elias E. , Parsons Ramon , Lu Chao , Efstratiadis Argiris , Philipone Elizabeth M. , Yoon Angela J. , Su Gloria H. 
Published: March 2020

Abstract

The PI3K signaling pathway is frequently mutated in head and neck squamous cell carcinoma (HNSCC), often via gain-of-function (GOF) mutations in the PIK3CA gene. Here, we present novel genetically engineered mouse models (GEMM) carrying a GOF allele Loxp-STOP-Loxp(LSL)-PIK3CAH1047R (E20) alone or in combination with heterozygous LSL-p53+/R172H (p53) mutation with tissue-specific expression to interrogate the role of oncogenic PIK3CA in transformation of upper aerodigestive track epithelium. We demonstrated that the GOF PIK3CA mutation promoted progression of 4-nitroquinoline 1-oxide–induced oral squamous cell carcinoma (OSCC) in both E20 single mutant and E20/p53 double mutant mice, with frequent distal metastasis detected only in E20/p53 GEMM. Similar to in human OSCC, loss of p16 was associated with progression of OSCC in these mice. RNA-seq analyses revealed that among the common genes differentially expressed in primary OSCC cell lines derived from E20, p53, and E20/p53 GEMMs compared with those from the wild-type mice, genes associated with proliferation and cell cycle were predominantly represented, which is consistent with the progressive loss of p16 detected in these GEMMs. Importantly, all of these OSCC primary cell lines exhibited enhanced sensitivity to BYL719 and cisplatin combination treatment in comparison with cisplatin alone in vitro and in vivo, regardless of p53 and/or p16 status. Given the prevalence of mutations in p53 and the PI3K pathways in HNSCC in conjunction with loss of p16 genetically or epigenetically, this universal increased sensitivity to cisplatin and BYL719 combination therapy in cancer cells with PIK3CA mutation represents an opportunity to a subset of patients with HNSCC.

Implications:
Our results suggest that combination therapy of cisplatin and PI3K inhibitor may be worthy of consideration in patients with HNSCC with PIK3CA mutation.
Age at Initiation and Frequency of Screening to Prevent Esophageal Squamous Cell Carcinoma in High-risk Regions: an Economic Evaluation
Authors: Wu Bin , Wang Zhenhua , Zhang Qiang 
Published: March 2020

Abstract

The aim of this study was to identify the economic screening strategies for esophageal squamous cell carcinoma (ESCC) in high-risk regions. We used a validated ESCC health policy model for comparing different screening strategies for ESCC. Strategies varied in terms of age at initiation and frequency of screening. Model inputs were derived from parameter calibration and published literature. We estimated the effects of each strategy on the incidence of ESCC, costs, quality-adjusted life-year (QALY), and incremental cost-effectiveness ratios (ICERs). Compared with no screening, all competing screening strategies decreased the incidence of ESCC from 0.35% to 72.8%, and augmented the number of QALYs (0.002-0.086 QALYs per person) over a lifetime horizon. The screening strategies initiating at 40 years of age and repeated every 1–3 years, which gained over 70% of probabilities that was preferred in probabilistic sensitivity analysis at a $1,151/QALY willingness-to-pay threshold. Results were sensitive to the parameters related to the risks of developing basal cell hyperplasia/mild dysplasia. Endoscopy screening initiating at 40 years of age and repeated every 1–3 years could substantially reduce the disease burden and is cost-effective for the general population in high-risk regions.
Surface roughness condition of field-aged polymer insulators at different installation area
Authors: Din A. , M. Piah M.A. , R. Abdullah A. , F. Kasri N. 
Published: March 2020

<span>This paper presents surface degradation assessment based on surface roughness condition for various field-aged high voltage polymer insulators that were installed at different locations. The measurement of arithmetical mean surface roughness is done, and statistical analysis is implemented in this study. Three groups of insulators labeled as 6 years, 12 years, 18 years, and with their respective controlled samples are tested using a surface roughness tester. Data measurements from the testing are analyzed in conjunction with visual observation to investigate an indication of surface degradation within the groups. Further statistical analysis is applied for the comparison of the surface roughness conditions. In order to observe the environmental stress factors that will affect the roughness condition, within the installation area, the virtual three-dimensional mapping program represented the Earth based on satellite imagery is utilized. The correlation analysis on all that three groups has indicated the positive outcomes with the roughness increased with respect to the age of insulator that located in quite similar environmental stress conditions. Regardless of the age of an insulator, the degradation due to surface roughness condition can be used to indicate what levels of environmental stress around the installation area have.</span>
HR analytics a roadmap for decision making: case study
Authors: Jabir Brahim , Falih Noureddine , Rahmani Khalid 
Published: March 2020

<p>In the socio-economic world, the human resources are in the most top phase of the enterprise evolution. This evolution began when the arithmetic, statistics are applicable over a vast of opportunities and used to identify problems and support decision. However, analytics has been emerged to provide predictions and understand the people performance based on available data.</p>In light of this vast amount of information, human resources services need to deploy a predictive management model and operating system of analytics that can be an efficient and an instead solution that can respond to the gaps of the traditional existing ones and facilitate the decision making. In this paper, we present a literature review of this HR analytics concept and a case study concerning the impact of interventions using an analytics solution.<p> </p>
Axial compressor fouling detection for gas turbine driven gas compression unit
Authors: Batayev Nurlan 
Published: March 2020

<span>One of the main reasons of the performance degradation of gas turbines is the axial compressor fouling due to air pollutants. Considering the fact that the fouling leads to high consumption of fuel, reducing of the axial compressor’s discharge air pressure and increasing of the exhaust temperature, thus designing a compressor degradation detection system will allow prevent such issues. Many gas turbine plants lose power due to dirty axial compressor blades, which can add up to 4% loss of power. In case of power plants, the power loosing could be observed by less megawatts produced by generator. But in case of gas compression stations the effect of power loosing could not be quickly detected, because there is not direct measurement of the discharge power produced by gas turbine. This article represents technique for detection of gas turbine axial compressor degradation in case of gas turbine driven natural gas compression units. Calculation of the centrifugal gas compressor power performed using proven methodology. Approach for evaluation of the gas turbine performance based on machine learning prediction model is shown. Adequacy of the model has been made to three weeks’ operation data of the 10 Megawatt class industrial gas turbine.</span>
Detecting leakage current by infrared thermography method
Authors: B. M Shariff M Riduan , L. Abdullah M.F. , B. A Latiff M Yusop , B. Mohamad Ahmad , B. Ismail Iszaizul 
Published: March 2020

<span>An alternating current leakage can happen in electrical installation such as switchgear panel. If it’s not being detected earlier and address properly, it might lead to unintended incident or accident such as fire, electric shock, and power supply trip. Occasionally, if it appears, tracing its root cause can be difficult. The conventional method is by isolating one by one of the electrical loads with aids of multimeter and clamp meter. <span class="apple-converted-space"> </span>Unfortunately, this conventional method could be a tedious job for installations involved in numbers of electrical panels. Therefore, an alternative method is deeming necessary. This paper describes research works on Infrared Thermography (IRT) as a new method in detecting leakage current as aids in resolving related electrical problems. The scope of study mingling around to determine IRT’s suitable parameters that represent the identification of leakage current, derive new mathematical equation correlating leakage current to IRT and conduct experiment accordingly. Two new equations derived which are leakage current relationship to thermogram and infrared net radiation power. The results of experiment adherence to the hypothesis drawn. Consequently, helps to realize predictive maintenance concept by detecting the root cause of leakage current ahead its triggering points of unintended incident and accident.</span>
Multi-objective attendance and management information system using computer application in industry strip
Authors: Alhilali Ahmed Hazim , Ali Nabeel Salih , Kadhim Mohammed Falih , Al-Sadawi Basheer , Alsharqi Haider 
Published: March 2020

<p>Information technology has played a vital factor in a competitive advantage for various business firms recently. Hence, catching up Investment of IT in most of the traditional industries for competitiveness purposes due to the relationship between organizational performance and IT use. In this study, attendance<br />and management information system (AMIS) was presented in the industry field based on multi-modules. Modules are management information, time- scheduling and attendance, and employee self- service module. The system used VB.NET environment for programming perspective as well MS SQL server for database storage. The system is secure and robust recordkeeping, keep employee up to date via self- service access, easy to use (simplified) and powerful time and attendance, active work schedules to make an employee happy and keep workers in the loop, as well, review and exporting different reports for staff manager, supervisor, and employee such as absence, vacation, time-off, employee wages, and etc.</p>
Review on measurement techniques and technologies to propose new rating scale measurement for shariah compliant hotel industry in Malaysia
Authors: Abdul Hasim Hazlin Fardila , Mohd Ariffin NorHapiza , Zaki Zakaria Mohd 
Published: March 2020

The tourism industry based on the Islamic approach is increasingly accepted by the tourists. This paper presents a review of measurement techniques and technologies’ scale measurement for Shariah Compliant Hotel Industry in Malaysia. Since the use of the rating system in Syariah Hotel Industry in Malaysia has yet to be implemented, it is difficult for the industry to determine the status level of a hotel. Furthermore, the consumers are unable to make the right choice based on their own needs. This study aims to propose new Rating Assessment for Scale Measurement system focusing on hotel industry based on Shariah Compliant standard known as Shariah Compliant Hotel Rating Measurement Scale System (SCHRMS). Scale measurement will be used to ensure all the Shariah Compliant Certificates are certified with certain level and follow the same standard. Multiple characteristics and categories must be clarified or considered when processing rating assessment for Shariah Compliance (SC) hotel. To solve the multiple characteristics’ issues, Fuzzy Analytic Hierarchy Process will be used. The process is accurate and suitable for selecting various types of information and can be used as a decision-making tool because it controls uncertain and inaccurate data. The raw data obtained from questionnaires as well as structured and unstructured interview will be analyzed using Rasch Analysis Method. Only this method is will be able to comply to the five main principles of analysis for a more meaningful and accurate conclusion of the research data obtained. Through this system that will developed, the problem related to rating measurement for SC hotel will be solved. The SC hotel rating system will be parallel to the conventional based hotel. The system is accepted for the convenience of Muslims as well as non-Muslims globally.
Zebra finches show spatial avoidance of near but not far distance traffic noise
Authors: Liu Quanxiao , Slabbekoorn Hans , Riebel Katharina 
Published: March 2020

Abstract
Traffic noise is on the rise worldwide. Birds have been reported to decrease in number and diversity near highways. This could be indirectly caused by traffic if birds avoid overall poorer habitat quality near highways or directly if birds actively avoid noisy conditions. To test whether traffic noise directly affects birds’ spatial preferences, we designed a preference test where zebra finches (Taeniopygia guttata) could move freely between noisy and quiet aviaries that only differed in the type of noise playbacks. During playback of high amplitude traffic noise recorded near from highways (5–15 m), birds spent significantly more time in the quieter aviary. Such spatial preferences were not observed during playbacks of moderate amplitude traffic noise recorded further away (200–400 m). Our result provides experimental support for the growing notion that traffic noise itself rather than the presence of vehicles may suffice to deter birds from busy roads.
Evaluation of a financial skills training programme for vulnerable young people at risk of homelessness
Authors: Fieldhouse Jon , Greatorex Harry 
Published: March 2020

Introduction A financial skills training programme (Cash Pointers) for young people at risk of homelessness had an unexpectedly positive impact on their wellbeing. A qualitative inquiry examined this phenomenon. Method Interviews with six trainees explored their experiences of the programme. A focus group comprising four programme workers added a service provider perspective. Findings Cash Pointers addressed trainees’ basic living and health needs. Additionally, trusting relationships with programme workers enabled trainees to feel safe, develop skills, pursue goals, manage health problems, improve relationships and engage in life roles. Trainees said Cash Pointers was accessible and responsive, offering advocacy, inter-agency liaison and hope. Programme workers said they balanced the need for quick results with patient relationship-building, were a well-supported team with a high degree of casework autonomy and felt skilled in the therapeutic use of self. Conclusion Cash Pointers created a psychologically informed environment within which trainees stabilised, acquired skills and progressed towards greater life satisfaction and inclusion. Improving financial skills can be profoundly transformative and an acceptable intervention for this population. Aspects of occupational therapy’s knowledge-base (dynamic systems thinking) and skillset (person-centred goal-setting, therapeutic use of self, creating enabling environments) can support this.
Conventional brain magnetic resonance imaging in the longitudinal evaluation of newly diagnosed systemic lupus erythematosus patients: a retrospective analysis from a single-centre cohort
Authors: Silvagni E , Bortoluzzi A , Borrelli M , Padovan M , Furini F , Govoni M 
Published: March 2020

Introduction Neuropsychiatric (NP) manifestations occur mostly in the early phases of the systemic lupus erythematosus (SLE) course. Nonspecific alterations are evident in conventional brain magnetic resonance imaging (MRI), regardless of clinically overt NP symptoms. The main aims of this study were to assess the prevalence of MRI abnormalities in newly diagnosed SLE, and to evaluate the impact of MRI changes during follow-up (FU) and the clinical course of NP symptoms. Materials and methods Newly diagnosed SLE patients with a baseline brain MRI and with available repeated MRI during FU were retrospectively evaluated. White-matter lesions and atrophy were recorded, comparing NPSLE and non-NPSLE patients. Cox proportional hazard models were used to compare NP events during FU with MRI data. Results Forty-four patients were included, 22 with NP events attributed to SLE. The baseline MRI scan was abnormal in 21 patients (47.73%). New NP events occurred in 17 patients, and worsening was found in repeated MRIs in 12 (27.27%). A worsening of MRI was associated with higher occurrence of new NP events during FU (adjusted hazard ratio 3.946 (1.175–13.253)). Conclusion Baseline MRI is useful in patients with an early diagnosis of SLE, allowing comparison with subsequent scans. In our study, radiological worsening of repeated brain MRI was associated with new NP events.
Intraoperative fundus inspection during surgery
Authors: Wong John , Sella Sara , Assia Ehud I 
Published: March 2020

Introduction: We describe a technique of intraoperative fundus visualization during anterior segment surgery using an anterior chamber air bubble. Methods: An air bubble that occupies one-half to two-thirds of the anterior chamber is injected via existing corneal incisions at any time during surgery. By focusing downwards and looking through the air bubble, an upright image of the posterior pole of the fundus is seen. The technique is demonstrated in a series of cases in the form of photos and supplementary video files. Results: Visualization of the fundus can be safely and effectively performed regardless of the lens status (phakic/pseudophakic/aphakic) of the eye. This technique allows the posterior pole and up to mid-peripheral fundus to be quickly inspected at any stage of surgery. Conclusion: This technique may help surgeons to briefly inspect the fundus in cases of unusual light reflex or following complicated surgery without any additional instrumentation.
Exploring Managers’ Opinions on Planning and Designing Adult Day Care Centers
Authors: Su Sheng-Wen , Lee Shwn-Jen , Tsai Mei-Wun , Luo Hong-Ji 
Published: March 2020

Objective: To explore managers’ opinions on planning and design of location, building type, spatial layout, and interior design of adult day care centers (ADCCs). Background: The planning and design of new ADCCs affect subsequent service users and workflows. Studies explore the factors affecting such planning and design using qualitative methods and from the perspective of users. Quantitative methods are rarely employed to explore factors affecting planning and opinions on the design of ADCCs from administrators’ perspective. Methods: Stratified sampling was used to collect data from managers of ADCCs in Taiwan. A mixed-method approach with an analytic hierarchy process was used to quantify the relative importance of factors affecting location and building type selections. Participants responded to open-ended interview questions followed by focus group interviews to examine the key points for spatial layout and interior design. Results: The managers deemed support and attitudes from local residents (group weight = .208) and authorities (group weight = .187) as their first two critical location selection criteria. Regarding their opinions on the conditions of building type, those that prioritized the products and technologies of facility design were deemed the most critical (group weight = .193), followed by those that valued daylight quality (group weight = .161). Six key points of spatial layout and interior design were obtained from the focus group interviews. Conclusions: This study provides a reference for the effective planning of operations, including geographical location, building type, spatial layout, and interior refurbishment and design.
Telemonitor care helps CPAP compliance in patients with obstructive sleep apnea: a systemic review and meta-analysis of randomized controlled trials
Authors: Chen Chongxiang , Wang Jiaojiao , Pang Lanlan , Wang Yanyan , Ma Gang , Liao Wei 
Published: March 2020

Background: This was a meta-analysis of continuous positive airway pressure (CPAP) compliance. We compared telemonitor (TM) care with usual care and supervised PAP titration (SPT) in the sleep unit with home auto-adjusting pressure titration (HAPT) in patients with obstructive sleep apnea (OSA). Methods: We searched PubMed, Web of Science, Scopus, and Medline for appropriate randomized controlled trials (RCTs) that compared TM care with usual care for patients with OSA. Review Manager 5.3 was used for all comparisons and analyses. Results: Our meta-analysis included 19 studies involving a total of 2464 patients with OSA; CPAP compliance was significantly higher in the TM care group [mean difference (MD) 0.68 h, 95% confidence interval (CI) 0.48–0.89 h, I2 = 49%] compared with the usual care group. When we compared SPT and HAPT, two groups did not exhibit significantly different levels of CPAP compliance (MD −0.34 h, 95% CI −0.72–0.05 h, I2 = 91%). Subgroup analysis comparing the SPT with HAPT in CPAP compliance was grouped by follow-up time (⩾3 months or <3 months). Once again, there were no between-group differences in either long-term (MD = 0.56 h, 95% CI = 1.39–0.26 h, I2 = 91%), or short-term (MD = 0.34 h, 95% CI = 0.26–0.27 h, I2 = 14%) follow up. Conclusions: TM care was associated with significantly greater CPAP compliance compared with usual care. Also, HAPT was not inferior to SPT for CPAP compliance.