bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence and outcome of prosthetic valve endocarditis after transcatheter aortic valve replacement in the Netherlands
Authors: Brouwer J. , van den Brink F. S. , Nijenhuis V. J. , Vossenberg T. N. , Delewi R. , van Mourik M. S. , den Heijer P. , Tanis W. , Kievit P. C. , Holvoet W. , Hermanides R. S. , ten Berg J. M. 
Published: April 2020

AbstractBackgroundTranscatheter aortic valve replacement (TAVR) is increasingly being used as an alternative to conventional surgical valve replacement. Prosthetic valve endocarditis (PVE) is a rare but feared complication after TAVR, with reported first-year incidences varying from 0.57 to 3.1%. This study was performed to gain insight into the incidence and outcome of PVE after TAVR in the Netherlands.MethodsA multicentre retrospective registry study was performed. All patients who underwent TAVR in the period 2010–2017 were screened for the diagnosis of infective endocarditis in the insurance database and checked for the presence of PVE before analysis of general characteristics, PVE parameters and outcome.ResultsA total of 3968 patients who underwent TAVR were screened for PVE. During a median follow-up of 33.5 months (interquartile range (IQR) 22.8–45.8), 16 patients suffered from PVE (0.4%), with a median time to onset of 177 days (IQR 67.8–721.3). First-year incidence was 0.24%, and the overall incidence rate was 0.14 events per 1000 person-years. Overall mortality during follow-up in our study was 31%, of which 25% occurred in hospital. All patients were treated conservatively with intravenous antibiotics alone, and none underwent a re-intervention. Other complications of PVE occurred in 5 patients (31%) and included aortic abscess (2), decompensated heart failure (2) and cerebral embolisation (1).ConclusionPVE in patients receiving TAVR is a relatively rare complication and has a high mortality rate.
Discrete roles of RNA helicases in human male germline and spermatogenesis
Authors: Tutak Katarzyna , Rozwadowska Natalia 
Published: April 2020

AbstractRNA helicases are known from their ability to bind and unwind double-stranded RNA initiating RNA processing events. These evolutionary conserved RNA binding proteins are broadly expressed in a variety of tissues; however, we can distinguish those, which represent tissue-specific expression pattern and play unique roles in certain cell lineages. For instance, some RNA helicases mediate transcriptomic changes triggering cell differentiation which results in specification and establishment of germline in a developing embryo. Others act as safeguards responsible for maintenance of DNA integrity in germ cell. In this article, we focus on selected DEAD/DEAH-box RNA helicases involved in germline development and spermatogenesis presenting their diverse functions and implications for male fertility.
Influence of combination forms of intact sub-layer and tectonically deformed sub-layer of coal on the gas drainage performance of boreholes: a numerical study
Authors: Zhao Wei , Wang Kai , Zhang Rong , Dong Huzi , Lou Zhen , An Fenghua 
Published: April 2020

AbstractHigh concentration and large flow flux of gas drainage from underground coal seams is the precondition of reducing emission and large-scale use of gas. However, the layered occurrence of coal seams with tectonically deformed sub-layers and intact sub-layers makes it difficult to effectively drain gas through commonly designed boreholes. In this study, the gas drainage performance in coal seams with different combinations of tectonically deformed sub-layers and intact sub-layers was numerically analyzed. The analysis results show that the gas drainage curve changes from a single-stage line to a dual-stage curve as the permeability ratios of Zone II (kII) and Zone I (kI) increase, raising the difficulty in gas drainage. Furthermore, a dual-system pressure decay model based on the first-order kinetic model was developed to describe the dual-stage characteristics of pressure decay curves with different permeability ratios. In the end, the simulation results were verified with reference to in-situ drainage data from literature. The research results are helpful for mines, especially those with layered coal seams comprising tectonically deformed sub-layers and intact sub-layers, to choose appropriate gas drainage methods and develop the original drainage designs for achieving better gas drainage performance.
Near-Infrared Light-Responsive Nitric Oxide Delivery Platform for Enhanced Radioimmunotherapy
Authors: Zhou Xuanfang , Meng Zhouqi , She Jialin , Zhang Yaojia , Yi Xuan , Zhou Hailin , Zhong Jing , Dong Ziliang , Han Xiao , Chen Muchao , Fan Qin , Yang Kai , Wang Chao 
Published: April 2020

AbstractRadiotherapy (RT) is a widely used way for cancer treatment. However, the efficiency of RT may come with various challenges such as low specificity, limitation by resistance, high dose and so on. Nitric oxide (NO) is known a very effective radiosensitizer of hypoxic tumor. However, NO cannot circulate in body with high concentration. Herein, an NIR light-responsive NO delivery system is developed for controlled and precisely release of NO to hypoxic tumors during radiotherapy. Tert-Butyl nitrite, which is an efficient NO source, is coupled to Ag2S quantum dots (QDs). NO could be generated and released from the Ag2S QDs effectively under the NIR irradiation due to the thermal effect. In addition, Ag is also a type of heavy metal that can benefit the RT therapy. We demonstrate that Ag2S NO delivery platforms remarkably maximize radiotherapy effects to inhibit tumor growth in CT26 tumor model. Furthermore, immunosuppressive tumor microenvironment is improved by our NO delivery system, significantly enhancing the anti-PD-L1 immune checkpoint blockade therapy. 100% survival rate is achieved by the radio-immune combined therapy strategy based on the Ag2S NO delivery platforms. Our results suggest the promise of Ag2S NO delivery platforms for multifunctional cancer radioimmunotherapy.
A MODULI STACK OF TROPICAL CURVES
Authors: CAVALIERI RENZO , CHAN MELODY , ULIRSCH MARTIN , WISE JONATHAN 
Published: April 2020

We contribute to the foundations of tropical geometry with a view toward formulating tropical moduli problems, and with the moduli space of curves as our main example. We propose a moduli functor for the moduli space of curves and show that it is representable by a geometric stack over the category of rational polyhedral cones. In this framework, the natural forgetful morphisms between moduli spaces of curves with marked points function as universal curves.
Our approach to tropical geometry permits tropical moduli problems—moduli of curves or otherwise—to be extended to logarithmic schemes. We use this to construct a smooth tropicalization morphism from the moduli space of algebraic curves to the moduli space of tropical curves, and we show that this morphism commutes with all of the tautological morphisms.
Why durability matters? Towards a Comparative Economic Sociology of Market Organization
Authors: Dobeson Alexander , Kohl Sebastian 
Published: April 2020

AbstractWhat can a good’s durability tell us about its market organization? This paper argues that the socially expected durability of goods is one of their most important features. It illuminates temporal and material aspects of market organization and social change across different markets. While recent literature in the sociology of markets tends to emphasize financial goods, intangible assets, and the service economy, markets for material durable and nondurable consumer goods are still surprisingly pervasive in everyday life and in the household economy, as well as in modern economies’ basic infrastructure. Based on a comparison of the extreme cases of durable housing and fresh fish markets, we come to the general finding that the higher a good’s expected durability, the smaller the share of its new production will be and the larger its aftermarkets. Furthermore, it will be more tightly linked to credit and insurance markets, and its market will be more volatile in the short-term, but more inert in the long-term. Beyond this static distinction, we show how socio-technical mechanisms can “durabilize” or “dedurabilize” goods and hence change their market form. By comparing markets along the durability dimension, this paper contributes to a comparative sociology of market organization that goes beyond single-market studies, while at the same time opening up space for a more dynamic understanding of social change and market segmentation over time.
Contact metamorphism of the Tethyan Sedimentary Sequence, Upper Mustang region, west-central Nepal
Authors: Lihter Iva , Larson Kyle P. , Shrestha Sudip , Cottle John M. , Brubacher Alex D. 
Published: April 2020

AbstractThe Upper Mustang region of west-central Nepal contains exposures of metamorphosed Tethyan Sedimentary Sequence rocks that have been interpreted to reflect either contact metamorphism related to the nearby Mugu pluton or regional metamorphism associated with the North Himalayan domes. New monazite geochronology results show that the Mugu leucogranite crystallized at c. 21.3 Ma, while the dominant monazite age peaks from the surrounding garnet ± staurolite ± sillimanite schists range between c. 21.7 and 19.4 Ma, generally decreasing in age away from the pluton. Metamorphic temperature estimates based on Ti-in-biotite and garnet–biotite thermometry are highest in the specimens closest to the pluton (648 ± 24°C and 615 ± 25°C, respectively) and lowest in those furthest away (578 ± 24°C and 563 ± 25°C, respectively), while pressure estimates are all within uncertainty of one another, averaging 5.0 ± 0.5 kbar. These results are interpreted to be consistent with contact metamorphism of the rocks in proximity to the Mugu pluton, which was emplaced at c. 18 ± 2 km depth after local movement across the South Tibetan detachment system had ceased. While this new dataset helps to characterize the metamorphic rocks of the Tethyan Sedimentary Sequence and provides new constraints on the thickness of the upper crust, it also emphasizes the importance of careful integration of metamorphic conditions and inferred processes that may affect interpretation of currently proposed Himalayan models.
Acritarchs from the Duolbagáisá Formation (Cambrian Series 2, Miaolingian) on the Digermulen Peninsula, Finnmark, Arctic Norway: towards a high-resolution Cambrian chronostratigraphy
Authors: Palacios Teodoro , Högström Anette E. S. , Ebbestad Jan Ove R. , Agić Heda , Høyberget Magne , Jensen Sören , Meinhold Guido , Taylor Wendy L. 
Published: April 2020

AbstractNew information on acritarchs from the Duolbagáisá Formation, Digermulen Peninsula, Arctic Norway, enable recognition of the three Cambrian Series 2 acritarch-based zones: theSkiagia ornata–Fimbriaglomerella membranacea,Heliosphaeridium dissimilare–Skiagia ciliosaandVolkovia dentifera–Liepaina planaAssemblagezones. Acritarchs of theSkiagia ornata–Fimbriaglomerella membranaceaZone (Cambrian Stage 3) appear near the base of the unit, close to an undetermined trilobite. In the Upper Member of the Duolbagáisá Formation, in levels withKjerulfian. sp. andElliptocephalan. sp., appears an assemblage with abundantSkiagia ciliosa, indicative of theHeliosphaeridium dissimilare–Skiagia ciliosaZone. A few metres higher appearLiepaina plana,Heliosphaeridium notatumandRetisphaeridium dichamerum, which indicate theVolkovia dentifera–Liepaina planaZone (Cambrian Stage 4). The transition between the Duolbagáisá Formation and the overlying Kistedalen Formation is marked by the appearance ofComasphaeridium longispinosum,Multiplicisphaeridium llynenseandEliasum llaniscum, diagnostic of the Miaolingian Series. This coincides with the disappearance ofSkiagia; occurrences ofSkiagiain Miaolingian strata consist of reworked material related to the Hawke Bay regression at the Cambrian Stage 4–Wuliuan transition. The absence ofSkiagiain higher levels of the Duolbagáisá Formation and Kistedalen Formation suggests that no unconformity formed during the Hawke Bay regression in this area. The chronostratigraphical significance of theSkiagia ornata–Fimbriaglomerella membranacea,Heliosphaeridium dissimilare–Skiagia ciliosaandVolkovia dentifera–Liepaina planazones is critically analysed. Correlation of the Duolbagáisá Formation with peri-Gondwanan terrains of Avalonia and Iberia is established. The Digermulen Peninsula has great potential as a reference section for establishing a Cambrian chronostratigraphy based on acritarchs.
PTSD as the second tsunami of the SARS-Cov-2 pandemic
Authors: Dutheil Frédéric , Mondillon Laurie , Navel Valentin 
Published: April 2020

AbstractSince the first cases, the coronavirus disease (COVID-19) rapidly spread around the world, with hundred−thousand cases and thousands of deaths. Post-traumatic stress disorder (PTSD) is a common consequence of major disasters. Exceptional epidemic situations also promoted PTSD in the past. Considering that humanity is undergoing the most severe pandemic since Spanish Influenza, the actual pandemic of COVID-19 is very likely to promote PTSD. Moreover, COVID-19 was renamed severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2). With a poor understanding of viruses and spreading mechanisms, the evocation of SARS is generating a great anxiety contributing to promote PTSD. Quarantine of infected patients evolved to quarantine of ‘infected’ towns or popular districts, and then of entire countries. In the families of cases, the brutal death of family members involved a spread of fear and a loss of certainty, promoting PTSD. In the context of disaster medicine with a lack of human and technical resources, healthcare workers could also develop acute stress disorders, potentially degenerating into chronic PTSD. Globally, WHO estimates 30–50% of the population affected by a disaster suffered from diverse psychological distress. PTSD individuals are more at-risk of suicidal ideation, suicide attempt, and deaths by suicide – considering that healthcare workers are already at-risk occupations. We draw attention towards PTSD as a secondary effect of the SARS-Cov-2 pandemic, both for general population, patients, and healthcare workers. Healthcare policies need to take into account preventive strategy of PTSD, and the related risk of suicide, in forthcoming months.
Nutritional problems in childhood and adolescence: a narrative review of identified disparities
Authors: Larson Nicole I. 
Published: April 2020

AbstractTo inform programmes and policies that promote health equity, it is essential to monitor the distribution of nutritional problems among young individuals. Common nutritional problems include overall low diet quality, the underconsumption and overconsumption of certain dietary components, unhealthy meal and snack patterns, problematic feeding practices and disordered eating. The objective of the present narrative review was to summarise recent evidence of disparities among US children (2–19 years) according to age, sex, socio-economic status, ethnicity/race and rural–urban location. Searches in PubMed® and MEDLINE® were completed to identify peer-reviewed research studies published between January 2009 and January 2019. Findings from the ninety-nine reviewed studies indicate adolescent females, young individuals from lower socio-economic households and individuals who identify as non-Hispanic Black race are particularly vulnerable populations for whom targeted strategies should be developed to address evidence of increased risk with regards to multiple aspects of nutritional wellbeing. Limitations of the existing evidence relate to the accuracy of self-reported dietary data; the need for consistent definitions of disordered eating; the focus on individual dietary componentsv.patterns; the complexities of categorising socio-economic status, ethnicity/race, and rural and urban areas; and the cross-sectional, observational nature of most research designs. There is an urgent need for research to address these limitations and fill a large gap in evidence on rural–urban differences in nutritional problems. It will further be important for future studies to build greater understanding of how nutritional problems cluster among population groups.
135 Evolution of a Study of Bilateral Prefrontal Transcranial Magnetic Stimulation (TMS) to Treat the Symptoms of Mild TBI (mTBI) and PTSD
Authors: Garland Jared S , Jaskot Emilia-Marie , Taylor Jerika , Buccellato Kiara , Atwal Navneet , Pasquina Paul F 
Published: April 2020

Disclaimer:The views expressed in this abstract are those of the authors and do not reflect the official policy of the Department of Army/Navy/Air Force, Department of Defense, or U.S. Government.Background:Traumatic brain injuries (TBIs) have affected nearly 380,000 service members since 2000. Comorbid posttraumatic stress disorder (PTSD) may result from and/or exacerbate sequelae of mild TBI (mTBI) and is suspected to affect up to 65% of service members with TBI. Conventional treatments for mTBI/PTSD symptoms have limited efficacy and are associated with undesirable side effects. Repetitive transcranial magnetic stimulation (rTMS) has shown promise in treating PTSD symptoms and been identified as a potential mTBI therapy, but is untested as a therapy for comorbid mTBI/PTSD.Methods:This double-blinded, prospective randomized, sham-controlled study consists of 30 treatment sessions 5 weeks of daily sessions followed by a two week taper of 3 and 2 sessions, respectively. Sessions consist of 3500 pulses administered to the left dorsolateral prefrontal cortex (dlPFC) at 10 Hz and 1500 pulses to the right dlPFC at 1 Hz. Approximately 60-80 participants will be randomized to receive active or sham rTMS. Primary outcome measures are the Posttraumatic Checklist 5 and the Rivermead Post-Concussion Questionnaire.Results:The study is ongoing, and 26 participants have been recruited to date. All patients were formally diagnosed with mTBI and reported moderate to severe PTSD symptoms. Preliminary data show no participants have withdrawn due to intolerability or indicated intolerability, despite the presence of minor discomforts such as headache. The majority of participants have been able to rest quietly or sleep during sessions, indicating high tolerability. Reported pain levels are low, with average ratings of 2.84/10.00 by week 2. One limitation was a high dropout rate.Conclusions:This study aims to provide guidance as to whether rTMS is an efficacious therapy for comorbid mTBI/PTSD. Preliminary data indicates it to be a tolerable and safe therapy. Future research should consider decreasing the demand of the study on patients schedules, and performing a comparison to other mTBI/PTSD treatments to determine what treatment is more efficacious.
140 Effects of Long-Term Valbenazine on Tardive Dyskinesia in KINECT 4: Post Hoc Response and Shift Analyses
Authors: Marder Stephen R. , Comella Cynthia L. , Singer Carlos , Farahmand Khodayar , Jimenez Roland 
Published: April 2020

Abstract:Study Objective:Valbenazine (VBZ) is a highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor approved for the treatment of tardive dyskinesia (TD), a persistent and potentially disabling movement disorder associated with prolonged antipsychotic exposure. Post hoc response and shift analyses were conducted using Abnormal Involuntary Movement Scale (AIMS) data from KINECT 4 (NCT02405091), a long-term open-label study in which participants received up to 48 weeks of open-label treatment with once-daily VBZ (40 or 80 mg).Methods:KINECT 4 included participants who met the following criteria: ages 18 to 85 years; DSM-IV diagnosis of schizophrenia, schizoaffective disorder, or mood disorder; neuroleptic-induced TD for ≥3 months prior to screening; stable psychiatric status (Brief Psychiatric Rating Scale score <50); no high risk of active suicidal ideation or behavior. Stable doses of concomitant medications to treat psychiatric and medical disorders were allowed. VBZ dosing was initiated at 40 mg, with escalation to 80 mg at Week 4 based on clinical assessment of TD and tolerability; a dose reduction to 40 mg was allowed if 80 mg was not tolerated. AIMS responses, ranging from ≥10% to 100% improvement from baseline in AIMS total score (sum of items 1-7), were analyzed at Week 48 based on scoring by site investigators. AIMS shift, conducted for each item (representing 7 different body regions), was defined as an improvement from a score ≥3 (moderate/severe) at baseline to a score ≤2 (none/minimal/mild) at Week 48.Results:103 participants had an available AIMS assessment at Week 48 (40 mg, n=20; 80 mg, n=83 [including 9 with a dose reduction]). At Week 48, 94.2% of participants had ≥30% total AIMS score improvement (40 mg, 90.0%; 80 mg, 95.2%) and 86.4% had ≥50% improvement (40 mg, 90.0%; 80 mg, 85.5%). The percentage of participants meeting the remaining AIMS response thresholds ranged from 9.7% (for 100% response) to 97.1% (for ≥10% response). In participants who had an AIMS item score ≥3 at baseline, shifts to a score ≤2 at Week 48 were as follows: 100% for lips, upper extremities, and lower extremities (VBZ 40 mg and 80 mg). Shift rates for the remaining regions were as follows (40 mg, 80 mg): face (100% [9/9], 96.9% [31/32]), jaw (100% [10/10], 97.6% [40/41]), tongue (100% [11/11], 97.9% [47/48]), trunk (87.5% [7/8], 88.9% [16/18]).Conclusions:After 48 weeks of treatment with once-daily VBZ (40 or 80 mg), >85% of KINECT 4 participants had a clinically meaningful AIMS response (≥30% total score improvement), a robust AIMS response (≥50% total score improvement), or an AIMS shift (from item score ≥3 at baseline to score ≤2 at Week 48). These results suggest that VBZ is an appropriate long-term treatment for many adults with TD.Funding Acknowledgements:This study was sponsored by Neurocrine Biosciences, Inc.