bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social gamification affordances in the green IT services: perspectives from recognition and social overload
Authors: Huang Jialiang , Zhou Liyun 
Published: November 2020

PurposeRecently, both practitioners and researchers are beginning to recognize the great potential of social gamification in green information technology (IT) services. This study focuses on the roles of three social gamification affordances (interactivity, cooperation and competition) in gamified green IT services use, from the perspectives of recognition and social overload.Design/methodology/approachAn online survey is conducted to examine the research model using structural equation modeling with users of Ant Forest, which is an example of green IT services in China.FindingsResults indicate that interactivity, cooperation and competition can positively affect recognition, which further positively affects green IT services use; however, interactivity and cooperation can increase social overload, which negatively affects green IT services use.Originality/valueThis study provides new insights into the effects of social gamification affordances in green IT services by investigating the effects of interactivity, cooperation and competition on recognition and social overload. In addition, this study highlights the positive effect of recognition and negative effect of social overload on gamified green IT services use, extending the literature reviews surrounding gamified services use.
Distributed leadership and exploratory and exploitative innovations: mediating roles of tacit and explicit knowledge sharing and organizational trust
Authors: Berraies Sarra , Hamza Khadija Aya , Chtioui Rached 
Published: November 2020

PurposeThe aim of this paper is to highlight the impact of distributed leadership (DL) on exploitative and exploratory innovations through the mediating effects of organizational trust (OT) and tacit and explicit knowledge sharing (KS).Design/methodology/approachFocusing on a quantitative approach, an empirical study was performed within a sample of information and communication technology Tunisian firms. The data collected was analyzed through the Partial Least Squares (PLS) method.FindingsFindings revealed that DL is a driver of tacit and explicit KS, and exploitative and exploratory innovations. It also highlighted that tacit KS is associated with these two types of innovation. In this line, results showed that tacit KS plays a mediating effect between DL and exploitative and exploratory innovations. Moreover, our research highlighted that DL has a positive impact on OT that in turn boosts tacit and explicit KS.Originality/valueThis paper investigates the links between DL and exploitative and exploratory innovations within knowledge intensive firms (KIFs) that have never been studied in the literature within the context of business firms. This paper pioneers the examination of the mediating roles of explicit and tacit KS and OT in these links as well. This paper highlights the importance of DL for KIFs and sheds the light on how this collectivist approach of leadership creates an atmosphere of trust and fosters tacit and explicit KS to boost exploitative and exploratory innovations.
Bibliometric analysis of a controversial paper on predatory publishing
Authors: Tsigaris Panagiotis , Teixeira da Silva Jaime A. 
Published: November 2020

PurposeIn 2017, one study (Derek Pyne; Journal of Scholarly Publishing; DOI: 10.3138/jsp.48.3.137; University of Toronto Press) in the “predatory” publishing literature attracted global media attention. Now, over three years, according to adjusted Google Scholar data, with 53 citations (34 in Clarivate Analytics' Web of Science), that paper became that author's most cited paper, accounting for one-third of his Google Scholar citations.Design/methodology/approachIn this paper, the authors conducted a bibliometric analysis of the authors who cited that paper.FindingsWe found that out of the 39 English peer-reviewed journal papers, 11 papers (28%) critically assessed Pyne's findings, some of which even refuted those findings. The 2019 citations of the Pyne (2017) paper caused a 43% increase in the Journal of Scholarly Publishing 2019 Journal Impact Factor, which was 0.956, and a 7.7% increase in the 2019 CiteScore.Originality/valueThe authors are of the opinion that scholars and numerous media that cited the Pyne (2017) paper were unaware of its flawed findings.
Digital fabrication of removable partial dentures made of titanium alloy and zirconium silicate micro-ceramic using a combination of additive and subtractive manufacturing technologies
Authors: Zhang Yan , Li Kai , Yu Hai , Wu Jiang , Gao Bo 
Published: November 2020

Purpose
This paper aims to present a new design for removable partial dentures (RPDs) for partially edentulous patients to improve the efficiency and quality of RPD manufacturing. Additive and subtractive manufacturing technologies and zirconium silicate micro-ceramic bonding in the aesthetic zone are used herein.

Design/methodology/approach
A case was presented. First, RPD digital definitive casts were acquired, and then digital frameworks with crown retainers and digital crowns were obtained by computer-aided design (CAD). The titanium alloy frameworks and resin crowns were fabricated by three-dimensional (3D) printing and computer-aided manufacturing (CAM) processes, respectively. The crowns adhered to the crown retainers. Ceramage bonding was used to reform the gingival anatomy in the aesthetic zone during the fabrication of the RPDs. The finished RPDs were assessed by a clinician and delivered to the patient.

Findings
The RPDs were conventionally assessed by a clinician, were deemed to be accurate and satisfied both the patient and clinician.

Originality/value
This novel method provides a way to fabricate RPDs with a combination of additive and subtractive manufacturing technologies. The design of the framework was different from that of a conventional framework because it contained the crown retainers, and the traditional base retainer no longer existed. Ceramage bonding was used to replicate the gingival anatomy in the aesthetic zone. The new RPDs provided accuracy and were less time-consuming to produce than those produced with the traditional method. The new method enables the digital manufacturing of nearly the entire RPDs.
Attachment style and clinical outcome within a DBT-informed Therapeutic Community
Authors: Dunlop Brendan James , McFetridge Mark Andrew 
Published: November 2020

Purpose
There is evidence that attachment style and clinical outcomes are related within Therapeutic Communities (TCs). This paper aims to examine any possible relationships between self-reported adult attachment style, therapy programme engagement and measures of psychological distress and dissociation on admission and discharge within a residential TC.

Design/methodology/approach
Ex-clients of the TC were contacted by post and invited to take part in this service evaluation. Additional data were sourced from a database of routinely collected outcome measures. Of 281 ex-clients, the final sample in this study was N = 32.

Findings
When attachment style is conceptualised dimensionally, participants identified most strongly with a fearful attachment style, and least with a preoccupied or secure style. A range of attachment styles were reported. A significant association was apparent between self-reported secure attachment and reduced levels of psychological distress upon discharge from the TC. The potential for changes in client attachment patterns following TC membership is discussed.

Research limitations/implications
The small sample size and correlational nature of this study means that results should be interpreted cautiously. Nevertheless, results are of clinical relevance for inpatient or residential therapy programmes (including TCs). Such programmes should routinely assess client attachment style to ensure appropriate interventions and adaptions are implemented.

Originality/value
To the best of the authors’ knowledge, to date, this is the first known study to report on the relationship between self-reported adult attachment style and psychological outcomes specifically for women with self-defeating behaviours within a TC.
Political trust during the Covid‐19 pandemic: Rally around the flag or lockdown effects?
Authors: SCHRAFF DOMINIK 
Published: November 2020

AbstractHow can we explain the rise in diffuse political support during the Covid‐19 pandemic? Recent research has argued that the lockdown measures generated political support. In contrast, I argue that the intensity of the pandemic rallied people around political institutions. Collective angst in the face of exponentially rising Covid‐19 cases depresses the usual cognitive evaluations of institutions and leads citizens to rally around existing intuitions as a lifebuoy. Using a representative Dutch household survey conducted over March 2020, I compare the lockdown effect to the dynamic of the pandemic. I find that the lockdown effect is driven by pre‐existing time trends. Accounting for non‐linearities in time makes the lockdown effect disappear. In contrast, more flexible modelling techniques reveal a robust effect of Covid‐19 infections on political trust. In line with an anxiety effect, I find that standard determinants of political trust – such as economic evaluations and social trust – lose explanatory power as the pandemic spreads. This speaks to an emotionally driven rally effect that pushes cognitive evaluations to the background.
Truly Preferential Treatment? Reconsidering the Generalised System of (Trade) Preferences with Competing Suppliers
Authors: Sharma Anupa , Grant Jason , Boys Kathryn 
Published: November 2020

AbstractEmpirical research on preferential treatment for developing economies has generally not considered how relative preferential margins might influence market access to a given destination market. In this paper, we develop and apply two indices to measure the tariff component of bilateral and multilateral trade restrictions less developed countries face in a given export destination. These indices are then used in a gravity model framework to re‐evaluate the trade effects of the Generalized System of Preferences (GSP). The trade facilitation impacts of the GSP are found to vary both across products and across export destinations. Overall results indicate that the GSP has increased relative market access of low‐income countries to developed country markets and boosted exports from these countries by 26–28%.
The potential effects of clinical antidiabetic agents on SARS‐CoV‐2
Authors: Qu Hua , Zheng Yi , Wang Yuren , Li Hongwei , Liu Xiufei , Xiong Xin , Zhang Linlin , Gu Jing , Yang Gangyi , Zhu Zhiming , Zheng Hongting , Ouyang Qin 
Published: November 2020

AbstractBackgroundCoronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2), is currently posing significant threats to public health worldwide. It is notable that a substantial proportion of patients with sever COVID‐19 have coexisting diabetic conditions, indicating the progression and outcome of COVID‐19 may relate to diabetes. However, it is still unclear whether diabetic treatment principles can be used for the treatment of COVID‐19.MethodsWe conducted a computational approach to screen all commonly used clinical oral hypoglycemic drugs to identify the potential inhibitors for the main protease (Mpro) of SARS‐CoV‐2, which is one of the key drug targets for anti‐COVID‐19 drug discovery.ResultsSix antidiabetic drugs with docking scores higher than 8.0 (cutoff value), including repaglinide, canagliflozin, glipizide, gliquidone, glimepiride, and linagliptin, were predicted as the promising inhibitors of Mpro. Interestingly, repaglinide, one of the six antidiabetic drugs with the highest docking score for Mpro, was similar to a previously predicted active molecule nelfinavir, which is a potential anti‐HIV and anti‐COVID‐19 drug. Moreover, we found repaglinide shared similar docking pose and pharmacophores with a reported ligand (N3 inhibitor) and nelfinavir, demonstrating that repaglinide would interact with Mpro in a similar way.ConclusionThese results indicated that these six antidiabetic drugs may have an extra effect on the treatment of COVID‐19, although further studies are necessary to confirm these findings.
Immune microenvironment features and efficacy of PD‐1/PD‐L1 blockade in non‐small cell lung cancer patients with EGFR or HER2 exon 20 insertions
Authors: Chen Kaiyan , Pan Guoqiang , Cheng Guoping , Zhang Fanrong , Xu Yanjun , Huang Zhiyu , Fan Yun 
Published: November 2020

BackgroundInsertions in exon 20 (Ex20ins) of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) are relatively insensitive to first‐ and second‐generation EGFR‐tyrosine kinase inhibitors (TKIs) in non‐small cell lung cancer (NSCLC). This study aimed to investigate the immune microenvironment features and efficacy of PD‐1/PD‐L1 blockade of NSCLC with EGFR and HER2 Ex20ins.MethodsClinical characteristics, coexisting mutations, and outcomes to EGFR‐TKIs and immune checkpoint blockade were reviewed for NSCLC patients with exon 20 mutations of EGFR or HER2. Data obtained included the molecular spectrum (extended genotyping for mutations in 324 cancer‐related genes), as well as tumor mutational burden (TMB), PD‐L1 protein expression, and the abundance of CD4+ and CD8+ tumor‐infiltrating lymphocytes (TILs).ResultsA total of 1270 NSCLC patients were identified. Of these, 504 (39.7%) cases had EGFR mutations and 6.9% (35/504) of them had EGFR Ex20ins. Meanwhile, 21 (1.7%) cases with HER2 Ex20ins were detected. Comprehensive genomic profiling identified A767_V769dup variant (25.0%) was the most common type in tumors with EGFR Ex20ins. Co‐occurring mutations were not uncommon including TP53 (45%), PIK3CA (20%), CDKN2A (10%), and EGFR amplification (20%). The average TMB was 3.3 mutations/megabase. PD‐L1 expression in patients with EGFR Ex20ins was significantly higher than for those with HER2 mutations (48.6% vs. 19.0%, P = 0.027). High TMB and PD‐L1 expression was independently associated with significantly poor prognosis (P = 0.025, P = 0.045, respectively) while there was no association between CD4+/CD8+ TILs and prognosis in EGFR or HER2 mutant NSCLC. Finally, patients harboring EGFR Ex20ins seemed to be sensitive to PD‐1/PD‐L1 blockage whereas it showed limited efficacy in patients with HER2 Ex20ins.ConclusionsNSCLC patients with EGFR/HER2 Ex20ins had similar genomic characteristics and distinct immune features. Patients with EGFR Ex20ins had significantly higher PD‐L1 expression than those with HER2 mutations, which may be the potential reason for the different responses to PD‐1/PD‐L1 blockage.
Digital Assets and Blockchain: Hackable, Fraudulent, or Just Misunderstood?*
Authors: Castonguay John “Jack” , Stein Smith Sean 
Published: November 2020

ABSTRACTUnhackable. Immutable. Fraud‐proof. These terms are frequently used to describe cryptocurrencies and the blockchain technology that underpins them. Together, they imply that a high degree of safety accompanies cryptocurrencies and blockchain ledgers. But is this understanding supported by the facts, or is it more based on the promise and theoretical construction of blockchain and cryptocurrencies? To better answer this question, we have compiled and analyzed existing research on initial coin offerings, security offerings, blockchain hacks and thefts, and data breaches of blockchain‐based platforms and digital wallets. In contrast to the popular press, we find that in practice, blockchain and cryptocurrencies are more prone to malfeasance, fraud, and manipulation than is commonly understood. The security and trust provided by blockchain as a technology tool are only as secure as the underlying code that establishes the blockchain, and the value derived from cryptocurrencies is only as trustworthy as the entity developing the cryptocurrency. Neither are without their vulnerabilities. Skepticism and proper due diligence should be maintained for any entity looking to utilize blockchain technology or invest in cryptocurrencies.
Interleukin‐9 produced by helper T cells stimulates interleukin‐8 expression in endometriosis
Authors: Tarumi Yosuke , Mori Taisuke , Okimura Hiroyuki , Maeda Eiko , Tanaka Yukiko , Kataoka Hisashi , Ito Fumitake , Koshiba Akemi , Kusuki Izumi , Kitawaki Jo 
Published: November 2020

AbstractProblemInflammation and immune responses play crucial roles in the development of endometriosis. Although interleukin‐9 (IL‐9) has a pro‐inflammatory function in chronic inflammatory diseases, its function in endometriosis remains unknown. Here, we aimed to investigate the significance of IL‐9 and IL‐9‐producing lymphocytes in endometriosis.Method of studySpecimens were obtained from patients with and without endometriosis. Peritoneal fluid (PF), peripheral blood (PB), and ovarian endometrioma (OE) tissues were analyzed for the proportion of CD4+IL‐9+ lymphocytes and IL‐9 concentration using flow cytometry and enzyme‐linked immunosorbent assay. OE, endometrium with endometriosis (EE), and normal endometrium (NE) were analyzed for IL‐9 receptor (IL‐9R) expression using immunohistochemical staining. IL‐9‐dependent changes in Interleukin‐8 (IL‐8) expression in endometrial stromal cells from OE (OESCs) were evaluated using real‐time PCR.ResultsThe proportion of CD4+IL‐9+ lymphocytes was higher in the PF, but not the PB, of patients with endometriosis than individuals without endometriosis (p < .05). However, IL‐9 levels in the PF did not differ between those with and without endometriosis. We detected CD4+ IL‐9+ lymphocytes in OE tissues and IL‐9R in OE tissues and OESCs. In OESC culture, IL‐9 significantly elevated IL‐8 expression in a dose‐dependent manner (p < .05), which was nullified by the addition of the anti‐IL‐9 receptor antibody. Furthermore, IL‐9 additively stimulated IL‐8 expression in the presence of TNF‐α (p < .05).ConclusionOur findings show that IL‐9 produced by helper T cells induces IL‐8 expression, suggesting that IL‐9 plays an important role in the development of endometriosis by stimulating IL‐8 expression.
The Haemostasis Traffic Light, a user‐centred coagulation management tool for acute bleeding situations: a simulation‐based randomised dual‐centre trial
Authors: Kataife E. D. , Said S. , Braun J. , Roche T. R. , Rössler J. , Kaserer A. , Spahn D. R. , Mileo F. G. , Tscholl D. W. 
Published: November 2020

SummaryThe Haemostasis Traffic Light is a cognitive aid with a user‐centred design to enhance and simplify situation awareness and decision‐making during peri‐operative bleeding. Its structure helps to prioritise therapeutic interventions according to the pathophysiology and the severity of the bleeding. This investigator‐initiated, randomised, prospective, international, dual‐centre study aimed to validate the Haemostasis Traffic Light by adapting it to the local coagulation protocols of two university hospitals. Between 9 January and 12 May 2020, we recruited 84 participants at the University Hospital Zurich, Switzerland, and the Italian Hospital of Buenos Aires, Argentina. Each centre included 21 resident and 21 staff anaesthetists. Participants were randomly allocated to either the text‐based algorithm or the Haemostasis Traffic Light. All participants managed six bleeding scenarios using the same algorithm. In simulated bleeding scenarios, the design of the Haemostasis Traffic Light algorithm enabled more correctly solved cases, OR (95%CI) 7.23 (3.82–13.68), p < 0.001, and faster therapeutic decisions, HR (95%CI) 1.97 (1.18–3.29, p = 0.010). In addition, the tool improved therapeutic confidence, OR (95%CI) 4.31 (1.67–11.11, p = 0.003), and reduced perceived work‐load coefficient (95%CI) −6.1 (−10.98 to −1.22), p = 0.020). This study provides empirical evidence for the importance of user‐centred design in the development of haemostatic management protocols.
Hypothermic machine perfusion can safely prolong cold ischemia time in deceased donor kidney transplantation. A retrospective analysis on postoperative morbidity and graft function
Authors: Adani Gian Luigi , Pravisani Riccardo , Tulissi Patrizia , Isola Miriam , Calini Giacomo , Terrosu Giovanni , Boscutti Giuliano , Avital Itzhak , Ekser Burcin , Baccarani Umberto 
Published: November 2020

AbstractIn deceased donor kidney transplantation (KT), a prolonged cold ischemia time (CIT) is a negative prognostic factor for KT outcome, and the efficacy of hypothermic machine perfusion (HMP) in prolonging CIT without any additional hazard is highly debated. We conducted a retrospective study on a cohort of 154 single graft deceased donor KTs, in which a delayed HMP, after a preliminary period of static cold storage (SCS), was used to prolong CIT for logistic reasons. Primary outcomes were postoperative complications as well as 1 year graft survival and function. 73 cases (47.4%) were managed with HMP and planned KT, while 81 (52.6%) with SCS and urgent KT. The median CIT in HMP group and SCS group was 29 hour:57 minutes [27‐31 hour:45 minutes] and 11 hour:25 minutes [9‐14 hour:30 minutes], respectively (P < .001). The period of SCS in the HMP group was significantly shorter than in the SCS group (10 vs. 11 hour:25 minutes, P = .02) as well as the prevalence of expanded criteria donors was significantly higher (43.8% vs. 18.5%, P < .01). After propensity score matching for these two baseline characteristics, the HMP and SCS groups showed comparable outcomes in terms of delayed graft function, vascular, and urologic complications, infections, and episodes of graft rejection. At 1 year follow‐up, serum creatinine levels were comparable between the groups. Therefore, the use of HMP to prolong the CIT and convert KT into a planned procedure seemed to have an adequate safety profile, with outcomes comparable to KT managed as an urgent procedure and a CIT nearly three time shorter.
Multimodal imaging comparison of perifoveal exudative vascular anomalous complex and resembling lesions
Authors: Smid Lisette M. , Verhoekx Jennifer S. N. , Martinez Ciriano José P. , Vermeer Koenraad A. , Yzer Suzanne 
Published: November 2020

AbstractPurposePerifoveal exudative vascular anomalous complex (PEVAC) was initially described as an isolated aneurysmal lesion in healthy eyes. Similar aneurysmal abnormalities may occur in association with retinal vascular diseases such as diabetic retinopathy or retinal vein occlusions (PEVAC‐resembling). The aim of this study was to compare several imaging characteristics of PEVAC and PEVAC‐resembling lesions.MethodsTen eyes with a PEVAC and 27 eyes with a PEVAC‐resembling lesion were included in this cross‐sectional study. They were all imaged with optical coherence tomography (OCT), OCT angiography (OCT‐A) and colour fundus photography (CFP). Several clinical, morphological and vascular characteristics were assessed and compared between both PEVAC types.ResultsAll PEVAC lesions were unilateral, while PEVAC‐resembling lesions appeared bilateral in 23% of patients (p > 0.05). Unilateral multifocal PEVAC‐resembling lesions were more frequently observed (56%) than unilateral multifocal PEVAC lesions (10%, p < 0.01). Furthermore, 90% of the PEVAC lesions were located within 500 µm from the centre of the fovea, while this was only true for 56% of the PEVAC‐resembling lesions (p > 0.05). No notable differences were observed in other studied characteristics.ConclusionsThe clinical, morphological and vascular features of PEVAC and PEVAC‐resembling lesions are similar based on multimodal imaging. Given the bilaterality and multifocality seen in PEVAC‐resembling lesions, an underlying retinal vascular disease may stimulate the quantity of aneurysmal abnormalities. Due to the similarities with PEVAC‐resembling lesions, PEVAC may also be considered a microangiopathy but with an unknown origin.