bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of a stepwise opioid-sparing analgesic protocol on in-hospital oxycodone use and discharge prescription after cesarean delivery
Authors: Landau Ruth , Romanelli Erik , Daoud Bahaa , Shatil Ben , Zheng Xiwen , Corradini Beatrice , Aubey Janice , Wu Caroline , Ha Catherine , Guglielminotti Jean 
Published: November 2020

IntroductionOpioid exposure during hospitalization for cesarean delivery increases the risk of new persistent opioid use. We studied the effectiveness of stepwise multimodal opioid-sparing analgesia in reducing oxycodone use during cesarean delivery hospitalization and prescriptions at discharge.MethodsThis retrospective cohort study analyzed electronic health records of consecutive cesarean delivery cases in four academic hospitals in a large metropolitan area, before and after implementation of a stepwise multimodal opioid-sparing analgesic computerized order set coupled with provider education. The primary outcome was the proportion of women not using any oxycodone during in-hospital stay (‘non-oxycodone user’). In-hospital secondary outcomes were: (1) total in-hospital oxycodone dose among users, and (2) time to first oxycodone pill. Discharge secondary outcomes were: (1) proportion of oxycodone-free discharge prescription, and (2) number of oxycodone pills prescribed.ResultsThe intervention was associated with a significant increase in the proportion of non-oxycodone users from 15% to 32% (17% difference; 95% CI 10 to 25), a decrease in total in-hospital oxycodone dose among users, and no change in the time to first oxycodone dose. The adjusted OR for being a non-oxycodone user associated with the intervention was 2.67 (95% CI 2.12 to 3.50). With the intervention, the proportion of oxycodone-free discharge prescription increased from 4.4% to 8.5% (4.1% difference; 95% CI 2.5 to 5.6) and the number of prescribed oxycodone pills decreased from 30 to 18 (−12 pills difference; 95% CI −11 to −13).ConclusionsMultimodal stepwise analgesia after cesarean delivery increases the proportion of oxycodone-free women during in-hospital stay and at discharge.
Reduced sexual contacts with non-steady partners and less PrEP use among MSM in Belgium during the first weeks of the COVID-19 lockdown: results of an online survey
Authors: Reyniers Thijs , Rotsaert Anke , Thunissen Estrelle , Buffel Veerle , Masquillier Caroline , Van Landeghem Ella , Vanhamel Jef , Nöstlinger Christiana , Wouters Edwin , Laga Marie , Vuylsteke Bea 
Published: November 2020

ObjectivesTo examine changes in the occurrence of physical sex with non-steady partners among men who have sex with men (MSM) in Belgium during the first weeks of the COVID-19 lockdown and associations with sociodemographic factors, sexual practices, drug, alcohol and pre-exposure prophylaxis (PrEP) use. A secondary objective was to explore changes in PrEP use and the need for PrEP follow-up.MethodsA cross-sectional online survey. The questionnaire was available in Dutch, French and English, between April 10 and 27 (2020), and disseminated via sexual health and lesbian, gay, bisexual, trans, queer or intersex organisations throughout Belgium. Eligibility criteria included being 18 years or older, not being exclusively heterosexual and living or being born in Belgium.ResultsThe sample included 694 MSM. Physical sex with non-steady partners decreased from 59.1% to 8.9% during the first weeks of the lockdown. Those who had sex with non-steady partners were significantly more likely to be HIV positive, to use PrEP or to have engaged in sexual practices such as group sex, chemsex and sex work before the lockdown, compared with their counterparts. Among those who used PrEP before the lockdown, 47.0% stopped using PrEP, 19.7% used event-driven PrEP and 33.3% used daily PrEP during the lockdown. Almost two-thirds of PrEP users had a PrEP care appointment in the weeks before the lockdown and a minority received follow-up elsewhere or online. Some PrEP users had concerns regarding their follow-up.ConclusionsMSM in our survey substantially reduced sexual contact with non-steady partners during the first weeks of the COVID-19 lockdown, suggesting that the risk for HIV and STI transmission in this period was low. We recommend ensuring access to sexual health services, such as HIV testing and follow-up for PrEP for the small group having multiple sex partners and engaging in sexual practices such as chemsex, or group sex, even in times of a pandemic threat.
Development of an Autophagy Score Signature for Predicting Overall Survival in Papillary Renal Cell Carcinoma
Authors: Gu Xiang , Chen Xiaojun , Zhu Lei , Song Wenbo , Wang Ali , Chu Junfeng , Wang Tao , Jiang Peng , Ge Yizhi 
Published: November 2020

Background. Autophagy is considered to be closely associated with cancer, functioning as either an anticancer or procancer mechanism depending on the cancer stage. However, the prognostic value of autophagy on papillary renal cell carcinoma (pRCC) remains unclear. In this study, our purpose was to determine the autophagy-related mRNA signature to predict the overall survival of patients with pRCC. Materials and Methods. A total of 284 patients with pathologic confirmed pRCC in The Cancer Genome Atlas (TCGA) dataset were recruited and included. We choose patients who have smoked less than 15 years but staging 3 or 4 (including nontobacco exposure) vs. more than 15 years but staging 1 or 2. Fourteen differentially expressed mRNAs were found with

fold

change
>
2

and

P

value < 0.001 through limma package after making a pair between nontobacco exposure or less than 15 years and tobacco exposure more than 15 years by matchIt package. Results. Six mRNAs were identified to be significantly associated with overall survival. Then, using a risk score based on the signature of these six mRNAs, we divided the patients into low-risk and high-risk groups with significantly different OS. Further multivariate Cox regression analyses revealed that the 6-mRNA signature was independent of age, TNM stage, and tumor type. In the present study, a novel 6-mRNA signature that is useful in survival prediction in pRCC patients was developed. If validated, this mRNA signature might assist in selecting high-risk subpopulation that needs more aggressive therapeutic intervention. The risk score involved in several cancer-related pathways was identified using gene set enrichment analysis. Conclusion. We initially generated a six autophagy-related genes’ signature, which correlates with AJCC N stage, tumor type, and pathological stage and independently predicts OS.
Deubiquitinase Ubiquitin‐Specific Protease 10 Deficiency Regulates Sirt6 signaling and Exacerbates Cardiac Hypertrophy
Authors: Zhang Dian‐Hong , Zhang Jie‐Lei , Huang Zhen , Wu Lei‐Ming , Wang Zhong‐Min , Li Ya‐Peng , Tian Xin‐Yu , Kong Ling‐Yao , Yao Rui , Zhang Yan‐Zhou 
Published: November 2020

Background
Cardiac hypertrophy (CH) is a physiological response that compensates for blood pressure overload. Under pathological conditions, hypertrophy can progress to heart failure as a consequence of the disorganized growth of cardiomyocytes and cardiac tissue. USP10 (ubiquitin‐specific protease 10) is a member of the ubiquitin‐specific protease family of cysteine proteases, which are involved in viral infection, oxidative stress, lipid drop formation, and heat shock. However, the role of USP10 in CH remains largely unclear. Here, we investigated the roles of USP10 in CH.

Methods and Results
Cardiac‐specific USP10 knockout (USP10‐CKO) mice and USP10‐transgenic (USP10‐TG) mice were used to examined the role of USP10 in CH following aortic banding. The specific functions of USP10 were further examined in isolated cardiomyocytes. USP10 expression was increased in murine hypertrophic hearts following aortic banding and in isolated cardiomyocytes in response to hypertrophic agonist. Mice deficient in USP10 in the heart exhibited exaggerated cardiac hypertrophy and fibrosis following pressure overload stress, which resulted in worsening of cardiac contractile function. In contrast, cardiac overexpression of USP10 protected against pressure overload‐induced maladaptive CH. Mechanistically, we demonstrated that USP10 activation and interaction with Sirt6 in response to angiotensin II led to a marked increase in the ubiquitination of Sirt6 and resulted in Akt signaling downregulation and attenuation of cardiomyocyte hypertrophy. Accordingly, inactivation of USP10 reduced Sirt6 abundance and stability and diminished Sirt6‐induced downstream signaling in cardiomyocytes.

Conclusions
USP10 functions as a Sirt6 deubiquitinase that induces cardiac myocyte hypertrophy and triggers maladaptive CH.
Admission Cardiac Diagnostic Testing with Electrocardiography and Troponin Measurement Prognosticates Increased 30‐Day Mortality in COVID‐19
Authors: Poterucha Timothy J. , Elias Pierre , Jain Sneha S. , Sayer Gabriel , Redfors Bjorn , Burkhoff Daniel , Rosenblum Hannah , DeFilippis Ersilia M. , Gupta Aakriti , Lawlor Matthew , Madhavan Mahesh V. , Griffin Jan , Raikhelkar Jayant , Fried Justin , Clerkin Kevin J. , Kim Andrea , Perotte Adler , Maurer Mathew S. , Saluja Deepak , Dizon José , Ehlert Frederick A. , Morrow John P. , Yarmohammadi Hirad , Biviano Angelo B. , Garan Hasan , Rabbani LeRoy , Leon Martin B , Schwartz Allan , Uriel Nir , Wan Elaine Y. 
Published: November 2020

Background
Cardiovascular involvement in coronavirus disease 2019 (COVID‐19) is common and leads to worsened mortality. Diagnostic cardiovascular studies may be helpful for resource appropriation and identifying patients at increased risk for death.

Methods and Results

We analyzed 887 patients (aged 64±17 years) admitted with COVID‐19 from March 1 to April 3, 2020 in New York City with 12 lead electrocardiography within 2 days of diagnosis. Demographics, comorbidities, and laboratory testing, including high sensitivity cardiac troponin T (hs‐cTnT), were abstracted. At 30 days follow‐up, 556 patients (63%) were living without requiring mechanical ventilation, 123 (14%) were living and required mechanical ventilation, and 203 (23%) had expired. Electrocardiography findings included atrial fibrillation or atrial flutter (AF/AFL) in 46 (5%) and ST‐T wave changes in 306 (38%). 27 (59%) patients with AF/AFL expired as compared to 181 (21%) of 841 with other non‐life‐threatening rhythms (
P
<0.001). Multivariable analysis incorporating age, comorbidities, AF/AFL, QRS abnormalities, and ST‐T wave changes, and initial hs‐cTnT ≥20 ng/L showed that increased age (HR 1.04/year), elevated hs‐cTnT (HR 4.57), AF/AFL (HR 2.07), and a history of coronary artery disease (HR 1.56) and active cancer (HR 1.87) were associated with increased mortality.

Conclusions
Myocardial injury with hs‐cTnT ≥20 ng/L, in addition to cardiac conduction perturbations, especially AF/AFL, upon hospital admission for COVID‐19 infection is associated with markedly increased risk for mortality than either diagnostic abnormality alone.
Introduction: Queerness, Time, and Biblical Interpretation
Authors: Moore Stephen D. , Buell Denise Kimber 
Published: November 2020

Abstract
This article introduces a thematic issue of Biblical Interpretation on the “temporal turn” in queer theory as it relates to biblical studies. Queer theorists of time have variously interrogated inherited concepts of history, historiography, historicity, and/or periodicity; the chrononormativity that regulates contemporary sexual lives; reproductive futurism, which evokes “our children” and their future to shore up heteronormativity and anathematize queerness; or explored the complex relations of queerness to the future and hence to hope. The contributions to this thematic issue, also introduced in the article, creatively harness these temporal theories and analytic strategies for queer biblical criticism and queer biblical hermeneutics.
Queer Necropolitics in the Decapolis: Here and There, Now and Then
Authors: McLellan Peter N. 
Published: November 2020

Abstract
This article seeks to disrupt the deadly deployment of boundaries that mark particular people as normative or queer, socially living or dead. Conversing with the Decapolis of Mark 5:1-20 and Washington D.C.’s prostitution free zones (pfz), the present project deploys a hauntological and critical spatial response, that locates points of contact between transwomen of color in the U.S. capital and the possessed Gerasenes. This article challenges biblical scholars to lean into historiography that sees such stories—from the tombs and from the pfz—as politically active in and of themselves, and with one another. Mark 5:1-20 is imagined here as a place constructed by alliances of queer bodies spatialized into unlivability. Such alliances are resources for thinking beyond the neocapitalist drive to create deadly normativity through insides and outsides, suggesting that biblical texts are always already infused with demands from places where life is suffocated.
A Backward Glance for a Queer Utopian Future: Genesis, Climate Change, and Hope as a Hermeneutic
Authors: Tipton Brian James 
Published: November 2020

Abstract
This article explores the ways in which biblical narratives and queer ecocritical voices can converge to recognize the importance of an intersectional climate change movement: to show that queer ecology matters. Specifically, I argue for an alternative approach to biblical ecocriticism, constructed around a queer(ed) biblical performance. I employ José Esteban Muñoz’s conceptualization of a queer utopian futurity, Lee Edelman’s critique of the political and rhetorical discourse centered on reproductive futurity, and Nicole Seymour’s blending of queer theory and ecocriticism in order to analyze conversations held by a cohort of the environmentally engaged nyc queer community. A performance and retelling of the story of Joseph(ine) in Genesis illustrates how queer engagement with biblical narratives offers an alternative to the dominant narrative of the climate change movement: “We must do it for our kids, for our grandkids.”
Biblical Interpretations and/as Queer Temporalities: A Response
Authors: Hidalgo Jacqueline M. 
Published: November 2020

Abstract
This response discusses the conjunction of “queer,” “temporalities,” and “biblical interpretation.” I argue that these essays demonstrate, through their turn to queer temporalities, that attending to queer time means attending to people in time, to their social practices, to dynamics of power, to violence, to survival, to the lost pasts whose voices still call out to our own, and to the choices we make in reading. The response also turns to borderlands theories, especially the work of Gloria Anzaldúa, and decolonial feminist thought, particularly that of María Lugones, in order to ask questions about biblical studies that cross borders.
Register and Rhetoric
Authors: Kienzle Alec 
Published: November 2020

Abstract
Despite 4QMMT having been informally called a “Halakhic Letter” since its first publication, more recently some scholars have expressed skepticism as to the original genre of this text. This article aims to provide empirical and theoretical support for what one might call the orthodox position: that this text was in fact a letter originally. By means of a detailed linguistic comparison between 4QMMT and the Damascus Document, it will be shown that despite many surface similarities between these texts in terms of structure and rhetoric, they present extremely divergent grammars. This in turn raises a fundamental question: how could two texts likely produced by the same community be so different linguistically? It will be argued that the most plausible explanation is that these two texts were written in distinct registers in order to accommodate to distinct literary genres. While the language of MMT can reasonably be called closer to the contemporary vernacular, the Damascus Document seems to be patterned after the language of the higher register of biblical narrative. From here, sociolinguistic research will be employed in an effort to show that the epistolary genre reliably reflects a lower register across languages and cultures, thereby justifying the orthodox position with respect to MMT.
Metaphysics as a Way of Life: Heymericus de Campo on Universals and the “Inner Man”
Authors: Calma Dragos 
Published: November 2020

Abstract
Pierre Hadot famously claimed that, between Antiquity and German Idealism, Western philosophy had lost its practical role of guiding the life of the practitioner. Scholars who challenged this view focused on two medieval models. This article argues that the overlooked work Colliget principiorum iuris naturalis, divini et humani philosophice doctrinalium by Heymericus de Campo postulates a third model. On the basis of St. Paul’s teaching about the “inner man,” Heymericus reconsiders the Aristotelian doctrines of abstraction and of being as such in relation to the Neoplatonic model of intellectual progression and interior conversion. In a realist conceptual framework, he holds that only metaphysics reflects the true nature of the human being inasmuch as it presupposes a way of life that assumes both the interaction with and withdrawal from the sensible world. However, Heymericus’ theory is neither limited to nor conditioned by Christian principles, but by Peripatetic philosophy (understood in the broad, Albertinian tradition).
The Rule of Contradictory Pairs, Insolubles and Validity
Authors: Read Stephen 
Published: November 2020

Abstract
The Oxford Calculator Roger Swyneshed put forward three provocative claims in his treatise on insolubles, written in the early 1330s, of which the second states that there is a formally valid inference with true premises and false conclusion. His example deployed the Liar paradox as the conclusion of the inference: ‘The conclusion of this inference is false, so this conclusion is false’. His account of insolubles supported his claim that the conclusion is false, and so the premise, referring to the conclusion, would seem to be true. But what is his account of validity that can allow true premises to lead to a false conclusion? This article considers Roger’s own account, as well as that of Paul of Venice, writing some sixty years later, whose account of the truth and falsehood of insolubles followed Roger’s closely. Paul endorsed Roger’s three claims. But their accounts of validity were different. The question is whether these accounts are coherent and support Paul’s claim in his Logica Magna that he endorsed all the normal rules of inference.
The effect of group size on the speed of decision making depends on compromise and predation risk across populations in the guppy Poecilia reticulata
Authors: Wade Amy S.I. , Ramnarine Indar W. , Ioannou Christos C. 
Published: November 2020

Abstract
While larger groups tend to be better at making decisions, very few studies have explored how ecological variables, including predation pressure, shape how group size affects decision making. Our cross-population study of wild-caught guppies (Poecilia reticulata) shows that leading individuals from larger groups made faster decisions when deciding to leave the start area and reach the junction of a Y-maze, which allows for compromise over timing. However, at the junction of the Y when the fish needed to make a mutually exclusive decision that does not allow for compromise, there was no effect of group size in high predation fish on decision speed. In fish from low predation habitats, speed was fastest at the intermediate group size with a decline in speed in the largest group size. These results challenge the view that decision making always improves with group size and shows this effect depends on ecological and decision-making conditions.
Growth curves of the yellowlegs shrimp Penaeus californiensis Holmes, 1900 (Decapoda, Penaeidae), using length data
Authors: Félix-Salazar Luis A. , Aragón-Noriega E. Alberto , Rodríguez-Domínguez Guillermo , Valenzuela-Quiñónez Wenceslao , Arroyo-Bustos Ana M. , Arzola-González Juan F. , Félix-Ortiz José A. 
Published: November 2020

Abstract
The yellowlegs shrimp Penaeus californiensis is an oceanic species that approaches the coastal zone for its reproduction. However, in the southern Gulf of California, this species also enters coastal lagoons to grow and reproduce. To test the hypothesis that the growth of P. californiensis differs between these two environments, monthly samplings of shrimp were made in the interior of the Navachiste coastal lagoon and its adjacent marine area. To determine growth, age groups were identified using the size structures over time. Five cases of the Schnute model were adjusted to the data, and the best case was selected using a multi-model selection approach. A sigmoid-shaped curve best represented the female data (case 2), and the inverted exponential curve (case 5; equivalent to the Von Bertalanffy growth function) was best for males. Average growth differed between sexes () but not between environments ().
Imperatives for Theories in Social Science: The North-South Divide Notwithstanding
Authors: Ogundiwin, Aaron Ola , Nwachukwu Joel N. 
Published: November 2020

Abstract
The paper underscores the place of theories in organizing social science data and experience. It holds that theories are indispensable to social research (The North-South divide notwithstanding), in view of the fact that the framework of knowledge and experience within which theories are established make a meaningful explanation of the world phenomenon reasonably possible. It delineates political philosophy and history of ideas from theory and thus, takes care of common mistake social scientists make differentiating between them. Furthermore, the paper on one hand, takes on the scientific requisites of theory such as assumption, concepts (and their functions), hypothesis (and its characteristics typology), law, models, paradigm and provides lucid conceptual analysis of each with a view to showing their relatedness to theory but not as synonyms to it. On the other hand, we singled out dependency theory in its emanation from knowledge and experience of underdevelopment of Third World countries, as the first and perhaps most relevant theoretic explanation of Africa’s underdevelopment. The paper posits that a good theory that will serve as a rudder for formulation of research questions, problem statement, as well as sustain the data analysis, and findings must parade some, if not all of the following qualities: precision and testability, empirical validity, parsimony, stimulation, and practicability.