bluuebunny/crossref_metadata_2025_split huggingface dataset:
Technology-Based Innovative Solutions for Improving Perinatal Care Utilization: A Network Meta-Analysis
Authors: Rahman Md. Obaidur , Islam Md. Rashedul , Rahman Md. Shafiur Shafiur , Alam Md. Ashraful , Taniguchi Hiroko , Jung Jenny , Lohan Maria , Ota Erika , Rahman Md Mizanur 
Published: November 2020

Abstract
Background: Technology-based interventions (TBIs) are widely being tested to integrate into the existing health system to increase preventative healthcare utilizations. Despite an uptake of TBIs, evidence remains inconclusive regarding its effectiveness due to a lack of comprehensive and concrete evaluations. This study aims to evaluate the impact and effectiveness of TBIs in improving antenatal visits, postnatal visits, and delivery care services in LMICs using Bayesian network meta-analysis. Methods: To identify the relevant studies, we will perform a comprehensive search of electronic databases and grey literatures with no language or publication date restriction. We will include experimental studies if they assess effectiveness of TBIs on improving perinatal care utilization among pregnant women. The primary outcomes are antenatal visits, postnatal visits, and delivery care. Two reviewers will independently identify eligible study and perform data extraction and quality assessment. We will use Bayesian meta-analysis to summarize the effect size of individual interventions for each outcome separately. In addition, Bayesian network meta-analyses will be used to pool the direct and indirect effects of all possible comparisons and to provide a hierarchy of all interventions for our primary outcomes. Furthermore, we will assess publication bias and certainty of evidence by GRADE approach for NMA.Discussion: The findings of this review will fill the gaps in evidence by synthesizing the impact of TBIs on a comprehensive range of reported outcomes in antenatal, postnatal, and delivery care. Furthermore, our meta-analyses will further guide policymakers or stakeholders on the potential use of TBIs in given contexts. Systematic review registration: PROSPERO Protocol ID CRD42019137331
Microarray Analysis of Hub Genes and Pathways in Damaged Cartilage Tissues of Knee
Authors: Aoqierbatu  , Luo Aqilatu , Ren Yizhong , Shi Yuting , Han Changxu , Na Yuyan 
Published: November 2020

Abstract
Background: The aim of this study was to identify genes and functional pathways associated with damaged cartilage tissues of knee using microarray analysis.Methods: The gene expression profile GSE129147 including including 10 knee cartilage tissues from damaged side and 10 knee non-weight-bearing healthy cartilage was downloaded and bioinformatics analysis was made. Results: A total of 182 DEGs including 123 up-regulated and 59 down-regulated genes were identified from the GSE129147 dataset. GO and pathway enrichment analysis confirmed that extracellular matrix organization, collagen catabolic process, antigen processing and presentation of peptide or polysaccharide antigen, and endocytic vesicle membrane were strongly associated with cartilage injury. Furthermore, 10 hub DEGs with a higher connectivity degree in PPI network were found such as POSTN, FBN1, LOX, IGFBP3, C3AR1, MMP2, ITGAM, CDKN2A, COL1A1, COL5A1.Conclusion: These hub genes and pathways provide a new perspective for revealing the potential pathological mechanisms and therapy strategy of cartilage injury.
Septic Hip Arthritis in Patients with Osteonecrosis of Femoral Head: Two Cases Report and Review of the Literature
Authors: Zhao Zhiping , Wang Xiangyu , Wang Changyao , Wang Yingzhen , Zhang Yongtao 
Published: November 2020

Abstract
Background: In patients with osteonecrosis of femoral head (ONFH), septic arthritis of the hip is rare, especially in the absence of factors likely to cause infection, which are often ignored by surgeons. Methods: Two patients seen at our hospital who had ONFH and concomitant septic arthritis of the hip joint were selected for inclusion in the study. Results: The clinical course suggests that ONFH developed prior to the hip infection. The two patients were not immune-compromised, and no remote septic focus was identified. The 2 patients, clinical manifestations of infection included fever and elevated white blood cell count. Elevated levels of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were observed in all 2 patients. In all patients, the results of hip magnetic resonance imaging (MRI) indicated hip infection. For 1 patients, culturing joint fluid revealed the presence of bacteria. In the second case, joint fluid was not cultured. In each case, the hip was debrided, and a spacer made of bone cement and containing vancomycin was implanted in the hip. Intravenous antibiotics were administered for 6 weeks postoperatively. There was no recurrence of infection, and total hip arthroplasty (THA) was performed 6 months after the operation. Conclusions: Septic hip is rare but exist in patients with ONFH. Elevated ESR and CRP contributed to the initial diagnosis; the results of hip MRI help to confirm the diagnosis. Overall, THA was an effective treatment.
Identification of Key Pathways and Genes in Polycystic Ovary Syndrome via Integrated Bioinformatics Analysis and Prediction of Small Therapeutic Molecules
Authors: Devarbhavi Praveenkumar , Telang Lata , Vastrad Basavaraj , Tengli Anandkumar Revanasiddapa , Vastrad Chanabasayya Mallikarjunayya , Kotturshetti Iranna 
Published: November 2020

Abstract
To add a enhance understanding of polycystic ovary syndrome (PCOS) at the molecular level, this investigation aimed to find the genes and crucial pathways linked with PCOS by using integrated bioinformatics analysis. Based on the expression profiling by high throughput sequencing data GSE84958 derived from the Gene Expression Omnibus, the differentially expressed genes (DEGs) between PCOS samples and normal controls were identified. With DEGs, we performed a series of functional enrichment analyses. Then, a protein–protein interaction (PPI) network, miRNA - target genes and TF - target gene networks were constructed and visualized, with which the hub gene nodes were screened out. Finally, validation of hub genes was performed by using receiver operating characteristic (ROC) and RT-PCR. Molecular docking studies performed. A total of 739 DEGs were screened out, among which 360 genes were up regulated and 379 genes were down regulated. GO enrichment analysis indicated that up regulated genes were mainly involved in peptide metabolic process, organelle envelope and RNA binding and the down regulated genes were significantly enriched in plasma membrane bounded cell projection organization, neuron projection and DNA-binding transcription factor activity, RNA polymerase II-specific. REACTOME pathway enrichment analysis showed that the up regulated genes were mainly enriched in translation and respiratory electron transport and the down regulated genes were mainly enriched in generic transcription pathway and transmembrane transport of small molecules. The top 10 hub genes in the constructed PPI network, miRNA - target gene network and TF - target gene network were SAA1, ADCY6, POLR2K, RPS15, RPS15A, CTNND1, ESR1, NEDD4L, KNTC1 and NGFR. The modules analysis showed that genes in the top 2 significant modules of PPI network were mainly associated with respiratory electron transport and signalling by NGF, respectively. We find a series of crucial genes along with the pathways that were most closely related with PCOS initiation and advancement. Our investigations provide a more detailed molecular mechanism for the progression of PCOS, detail information on the potential biomarkers and therapeutic targets.
Initial engagement and persistence of health risk behaviors through adolescence: longitudinal findings from urban South Africa
Authors: Kowalski Alysse , Addo O. Yaw , Kramer Michael R , Martorell Reynaldo , Norris Shane A , Waford Rachel N , Richter Linda M , Stein Aryeh 
Published: November 2020

Abstract
Background: Little is known about longitudinal patterns of adolescent health risk behavior initial engagement and persistence in low- and middle-income countries. Methods: Birth to Twenty Plus is a longitudinal birth cohort in Soweto-Johannesburg, South Africa. We used reports from Black African participants on cigarette smoking, alcohol, cannabis, illicit drug, and sexual activity initial engagement and adolescent pregnancy collected over 7 study visits between ages 11 and 18 y. We fit Kaplan-Meier curves to estimate behavior engagement or adolescent pregnancy, examined current behavior at age 18 y by age of first engagement, and performed a clustering analysis to identify patterns of initial engagement and their sociodemographic predictors. Results: By age 13 y, cumulative incidence of smoking and alcohol engagement were each >21%, while the cumulative incidence of other behaviors and adolescent pregnancy were <5%. By age 18 y (15 y for cannabis), smoking, alcohol, and sexual activity engagement estimates were each >65%, cannabis and illicit drug engagement were each >16%; adolescent pregnancy was 31%. Rates of engagement were higher among males. Current risk behavior activity at age 18 y was generally unrelated to age of initial engagement. We identified three clusters reflecting low, moderate, and high-risk patterns of initial risk behavior engagement. One-third of males and 17% of females were assigned to the high-risk cluster. Sociodemographic factors were not associated with cluster membership.Conclusions: Among urban dwelling Black South Africans, risk behavior engagement across adolescence is common and clusters into distinct initial engagement patterns unrelated to the sociodemographic factors assessed. Patterns of risk behavior initial engagement have implications for the timing of primary and secondary public health interventions and supports integrated prevention efforts that consider multiple behaviors simultaneously.
Tumor Response Prediction in 90Y Radioembolization with PET-based Radiomics Features and Absorbed Dose Metrics
Authors: Wei Lise , Cui Can , Xu Jiarui , Kaza Ravi , Naqa Issam El , Dewaraja Yuni K 
Published: November 2020

Abstract
Purpose To evaluate whether lesion radiomics features and absorbed dose metrics extracted from post-therapy 90Y PET can be integrated to better predict outcomes in microsphere radioembolization of liver malignancies. Methods Given the noisy nature of 90Y PET, first, a liver phantom study with repeated acquisitions and varying reconstruction parameters was used to identify a subset of robust radiomics features for the patient analysis. In 36 radioembolization procedures, 90Y PET/CT was performed within a couple of hours to extract 46 radiomics features and estimate absorbed dose in 105 primary and metastatic liver lesions. Robust radiomics modeling was based on bootstrapped multivariate logistic regression with shrinkage regularization (LASSO) and Cox regression with LASSO. Nested cross-validation and bootstrap resampling were used for optimal parameter/feature selection and for guarding against overfitting risks. Spearman rank correlation was used to analyze feature associations. Area under the receiver-operating characteristics curve (AUC) was used for lesion response (at first follow-up) analysis while Kaplan-Meier plots and c-index were used to assess progression model performance. Models with absorbed dose only, radiomics only and combined models were developed to predict lesion outcome.Results The phantom study identified 15/46 reproducible and robust radiomics features that were subsequently used in the patient models. A lesion response model with zone percentage (ZP) and mean absorbed dose achieved an AUC of 0.729 (95%CI: 0.702-0.758) and a progression model with zone size nonuniformity (ZSN) and absorbed dose achieved a c-index of 0.803 (95% CI: 0.790-0.815) on nested cross validation (CV). Although the combined models outperformed the radiomics only and absorbed dose only models, statistical significance was not achieved with the current limited data set to establish expected superiority.Conclusion We have developed new lesion-level response and progression models using textural radiomics features, derived from 90Y PET combined with mean absorbed dose for predicting outcome in radioembolization. These encouraging, but limited results, will need further validation in independent and larger datasets prior to any clinical adoption.
The concept of a cementless isoelastic monoblock cup made of highly cross-linked polyethylene infused with vitamin E: Radiological analyses of migration and wear using EBRA and clinical outcomes at mid-term follow-up
Authors: Afghanyar Yama , Joser Sebastian , Tecle Jonas , Drees Philipp , Dargel Jens , Rehbein Philipp , Kutzner Karl Philipp 
Published: November 2020

Abstract
BackgroundThe newest generation of cementless titanium coated, isoelastic monoblock cup with vitamin E-blended highly cross-linked polyethylene (HXLPE) has been introduced to the market in 2009. Aim of the present study was to obtain mid-term data including the analyses of migration and wear.MethodsThe present prospective study investigated 101 primary total hip arthroplasty (THA) cases in 96 patients at a single institution. Patients were allowed full weight-bearing on the first day postoperatively. Harris hip score (HHS) as well as pain and satisfication on visual analogue scale (VAS) were assessed during a mean follow-up of 79.0 months. Migration and wear were assessed using Einzel-Bild-Roentgen-Analyse (EBRA) software. Additionally, radiological alterations in the acetabular bone and complications were documented.ResultsAt mid-term follow-up (mean 79.0 months (range: 51.8 – 101.7)), 81 cases with complete clinical and radiological data were analyzed. In 42 hips utilisable EBRA measurements were obtained. HHS was 91.1 (range 38.0 – 100.0), satisfaction on VAS was 9.6 (range 6.0 – 10.0), rest pain on VAS was 0.2 (range 0.0 – 4.0), and load pain on VAS was 0.6 (range 0.0 – 9.0). Mean migration was 0.86 mm (range: 0.0 – 2.56) at 24 months and 1.34 mm (range: 0.09 – 3.14) at 5 years. Mean annual migration rate was 0.22 (range: -0.24 – 1.34). Mean total wear was 0.4 mm (range: 0.03 – 1.0). The mean annual wear rate was 0.06 mm per year (range: 0.0 – 0.17). Radiographic analysis showed osteolysis in none of the cases and no revision surgeries had to be performed.ConclusionUsing vitamin-E blended HXLPE in cementless isoelastic monoblock cups, no signs of osteolysis were obvious and no cases of aseptic loosening occurred. There was no need of revision surgery at mid-term. Values for cup migration and wear stay well below the benchmarks which are considered predictive for potential future failure.Trial registrationThe trial registration number on ClinicalTrial.gov: NCT04322916 (retrospectively registered at 26.03.2020).
Hand injuries in sports – a retrospective analysis of 364 cases
Authors: Stoegner Viola-Antonia , Kaltenborn Alexander , Laser Hans , Vogt Peter Maria 
Published: November 2020

Abstract
Background: Hand injuries are common in sports and associated with high dropout rates and costs. Hence, efforts should strive for further risk prevention measures in order to increase safety in sports. This implies knowledge of sports injury risk profiles. So far, major surveillance programs exist mainly in Anglo-American countries, reflecting the specific concerns of sports in this part of the world. Data on sports injuries within Europe are scarce. As sports behaviour appears to vary demographically, we hypothesised that risk injury profiles differ as well. Methods: To assess, whether the described sports injuries of the hand are applicable to the German population, we performed a five-year retrospective, single-centre analysis of sports-related hand injuries, using the data of the Enterprise Clinical Research Warehouse of the Hannover Medical School.Results: Notable differences in comparison to other data were observed. Ball sports, cycling and equestrian sports caused most of the recorded hand injuries, which were predominantly fractures of the wrist and hand. Hand injuries in equestrian sports were associated with significantly higher operation and hospitalisation rates as well as a significantly longer inpatient treatment. Conclusion: Risk profiles for sports-related hand injuries appear to differ not only age- and sex-dependent, but also geographically. National as well as European hand trauma registries as well as a broad registry participation are necessary in order to accurately assess these risk patterns in Europe and hence reduce hand injuries and the sequelae.
Comparison of three treatment methods for simple bone cyst in children
Authors: Zhang Ke Xue , Chai Wei , Zhao Jia Jia , Deng Jun Hao , Peng Zhan , Chen Ji Ying 
Published: November 2020

Abstract
Background Unicameral bone cyst (UBC) is a benign tumor whose clinical treatments and efficacy are controversial. The purpose of this study was to evaluate the efficacy of the elastic stable intramedullary nail (ESIN), the injection of autologous bone marrow (ABM) and the combination of ESIN and ABM in the treatment of simple bone cyst of children.Methods 83 children with simple bone cyst were analyzed retrospectively. 28 cases were treated with ABM. 28 cases were treated with ESIN. 27 cases were treated with ABM and ESIN. All cases were diagnosed through X-ray, CT or MRI scans. For the suspicious ones, pathological biopsy was performed for an accurate diagnosis. X-ray examinations were carried out for the postoperative follow-up. Capanna criteria for bone cyst was used for the postoperative evaluation of the three methods.Results All the cases accomplished the follow-up. The effective rate of ABM+ESIN group was significantly higher than that of the ABM group (P<0.05), and the cure rates of ESIN group and ABM+ESIN group were higher than that of ABM group (P<0.05, respectively). The cure time in ESIN group was lower than that of the other two groups (P<0.05, respectively). The times for admission were 2.0±0.0 in ESIN group, 5.7±1.9 in ABM group and 4.7±2.4 in ABM+ESIN group (P<0.05 when compared with each other).Conclusions The method of ABM combined with ESIN for children bone cyst has the highest effective and curative rates. For individual method, ESIN has a higher effective rate and curative rate than that of ABM with the lowest time of admission.
Canine helminthiases and associated risk factors in Kigali city, Rwanda
Authors: Ntampaka Pie , Niragire François , Nyaga Philip Njeru , Habarugira Gervais 
Published: November 2020

Abstract
Background: Canine helminthiases pose a public health risk to humans and livestock. However, the prevalence of canine helminthiases in Rwanda is unknown. This study aimed to determine the prevalence of canine helminthiases and to identify the associated risk factors in Kigali city. A cross-sectional study involved 93 dogs selected across Kigali city. Faecal samples were collected from apparently healthy dogs and helminth eggs were identified and quantified under microscope using McMaster technique. Risk factors for canine helminthiases were analysed by multivariable binary logistic regression analysis.Results: The overall prevalence of intestinal helminthiases in dogs was 39.8%, 95% CI: 29.84- 49.73. The most prevalent species was Ancylostoma spp with 32.3%, 95% CI: 22.76-41.76. About 38.7% and 3.4% (n= 31) of dogs having ancylostomosis and toxocarosis had high egg counts per gram of faeces (≥ 550) each. Logistic regression analysis showed that dog's age, dog feeding practices and location were significantly associated with the prevalence of canine helminthiases. Compared to dogs aged < 1 year, the adjusted odds ratio (AOR) of developing helminthiases was more than 10 times higher for dogs aged between 1- 2.5 years (AOR=10.310; 95% CI: 1.557- 68.288), more than 5 times greater for dogs aged between 2.5-5 years, and more than 7 times greater for dogs that were at least 5 years old (AOR=7.543; 95% CI: 1.1360.101). Furthermore, the AOR was more than 5 times higher (AOR=5.41; 95% CI: 1.28- 22.87) for dogs fed on raw animal origin supplements, leftovers from family food and restaurants and more than 13 times higher (AOR=13.581; 95% CI: 2.194-84.050) for dogs that ate leftovers from household food and scavenged compared to those that ate food prepared for them, respectively. Conclusions: All the identified helminths including Ancylostoma spp, Toxocara canis, and tapeworms are zoonotic, and they pose a public health risk to humans. There is an urgent need of increasing the awareness among pet owners on the role of dogs in transmitting zoonotic helminthiases to other animals and to humans. The control of zoonotic helminthiases in dog population should focus on taking appropriate measures to promote hygienic dog feeding practices at all ages.
Patient perceptions of students in a longitudinal clerkship in Taiwan: a qualitative study
Authors: Chang Yaw-Wen , Hirsh David A. , Fang Wen-Hui , Li Honghe , Tzeng Wen-Chii , Kao Senyeong 
Published: November 2020

Abstract
Background: Patient-centered care is a core component of medical professionalism. East Asian cultures hold different conceptualizations of medical professionalism than Western cultures. To support patient-centered care, education leaders in Taiwan restructured clinical education and implemented the first longitudinal integrated clerkship (LIC) in East Asia. We aimed to investigate patients’ perceptions of longitudinal relationships with the LIC students within Taiwan’s Confucian cultural and social context.Methods: We invited patients or their family members who were cared for longitudinally by a LIC student to participate in the study. Participating patients or their family members undertook semi-structured interviews. We analyzed data qualitatively using a general inductive approach to identify themes in the patients’ descriptions of their experiences interacting with the LIC students.Results: Twenty-five patients and family members participated in interviews: 16 patients and 9 family members. Qualitative analysis of interview transcripts identified three themes from patients’ experience receiving care from their LIC students: care facilitation, companionship, and empathy. To provide care facilitation, LIC students served as a bridge between the physicians and patients. Students served patients by reminding, consulting, tracking disease progression, and researching solutions for problems. To provide companionship, students accompanied patients interpersonally like a friend or confidant who listens and provides a presence for patients. To provide empathy, patients reported that students showed sincere concern for patients’ experience, feelings, and mood.Conclusion: In our study, Taiwanese patients’ perspectives of LIC students suggested the value of care facilitation, companionship, and empathy. We discuss these themes within the context of Confucian culture and the Taiwanese context of care.