bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multimodality Imaging of Fluid Saturation and Chemical Transport for Two-Phase Surfactant/Polymer Floods in Porous Rocks
Authors: Rovelli Andrea , Brodie James , Rashid Bilal , Tay Weparn J. , Pini Ronny 
Published: December 2024

Abstract
Multicomponent, two-phase flow in porous media is a problem of practical relevance that remains difficult to study experimentally. Advanced methodologies are needed that enable the monitoring of both the saturation of each fluid phase within the pore space and the concentration of the chemical species within the fluids. We present an approach based on multimodality imaging and apply it to the case study of surfactant/polymer flooding in a sandstone for enhanced oil recovery. X-ray computed tomography and positron emission tomography (PET) are applied for the asynchronous acquisition of dynamic profiles of saturations (aqueous and oleic) and of the solute concentration within the surfactant/polymer slug, respectively. This complementary dataset enables precise investigation of the evolution of both the oil bank and the induced mixing at its rear arising from the surfactant/polymer flooding process. The dilution index, intensity of segregation and the spreading length are used to quantify the degree of mixing within the surfactant/polymer slug as a function of time from the spatial structure of the solute concentration field. Relative to the single-phase flow scenario, a threefold increase in dispersivity is observed. We demonstrate that mixing is systematically overestimated if only the PET dataset is used—highlighting the importance of implementing multimodality imaging. We also show that the advection–dispersion equation model, parameterised using the dispersivity derived from the experiments, provides reasonable estimates for the rate of both mixing and spreading.
Assessment of the stability of intracranial aneurysms using a deep learning model based on computed tomography angiography
Authors: Zeng Lu , Wen Li , Jing Yang , Xu Jing-xu , Huang Chen-cui , Zhang Dong , Wang Guang-xian 
Published: December 2024

Abstract

Purpose
Assessment of the stability of intracranial aneurysms is important in the clinic but remains challenging. The aim of this study was to construct a deep learning model (DLM) to identify unstable aneurysms on computed tomography angiography (CTA) images.

Methods
The clinical data of 1041 patients with 1227 aneurysms were retrospectively analyzed from August 2011 to May 2021. Patients with aneurysms were divided into unstable (ruptured, evolving and symptomatic aneurysms) and stable (fortuitous, nonevolving and asymptomatic aneurysms) groups and randomly divided into training (833 patients with 991 aneurysms) and internal validation (208 patients with 236 aneurysms) sets. One hundred and ninety-seven patients with 229 aneurysms from another hospital were included in the external validation set. Six models based on a convolutional neural network (CNN) or logistic regression were constructed on the basis of clinical, morphological and deep learning (DL) features. The area under the curve (AUC), accuracy, sensitivity and specificity were calculated to evaluate the discriminating ability of the models.

Results
The AUCs of Models A (clinical), B (morphological) and C (DL features from the CTA image) in the external validation set were 0.5706, 0.9665 and 0.8453, respectively. The AUCs of Model D (clinical and DL features), Model E (clinical and morphological features) and Model F (clinical, morphological and DL features) in the external validation set were 0.8395, 0.9597 and 0.9696, respectively.

Conclusions
The CNN-based DLM, which integrates clinical, morphological and DL features, outperforms other models in predicting IA stability. The DLM has the potential to assess IA stability and support clinical decision-making.
The Implementation Climate for Integrating Buprenorphine Prescribing into Rural Primary Care
Authors: Fenstemaker Cheyenne , Abrams Elizabeth A. , King Katherine , Obringer Benjamin , Brook Daniel L. , Go Vivian , Miller William C. , Dhanani Lindsay Y. , Franz Berkeley 
Published: December 2024

Abstract
Background
Rural communities have been significantly affected by opioid use disorder (OUD) and related harms but have less access to evidence-based medications for opioid use disorder (MOUD), such as buprenorphine. Given the shortage of specialists in these areas, rural primary care is an important setting to expand buprenorphine access, but implementation is limited.

Objective
To explore implementation climate factors that support or hinder buprenorphine implementation in rural primary care.

Design
A qualitative study design using in-depth interviews.

Participants
Primary care physicians, nurse practitioners (NPs), and physician associates (PAs) practicing in rural Ohio counties.

Approach
Between December 2022 and March 2023, we interviewed participants about their perspectives on buprenorphine prescribing, including using rural primary care as an implementation setting for buprenorphine. Using a deductive, framework-based approach, codes were grouped based on the Consolidated Framework for Implementation Research (CFIR) inner setting factors that contribute to a positive implementation climate for an intervention.

Key Results
Three implementation climate constructs emerged as decision points for whether to implement buprenorphine in rural primary care: (1) relative priority: the extent to which OUD treatment should be prioritized over other chronic diseases; (2) compatibility: whether buprenorphine prescribing protocols are compatible with the rural primary care setting; (3) tension for change: the extent to which current buprenorphine access shortages in rural communities can be tolerated. Participants expressed mixed perspectives on whether the implementation climate in rural primary care currently supports buprenorphine prescribing.

Conclusion
Implementation strategies targeted toward the implementation climate are critical to support buprenorphine prescribing in rural primary care.
Der talentierte Mr. Coach? – Eine empirische Untersuchung zu narzisstischer Grandiosität bei Coaches im Vergleich zur Normalbevölkerung
Authors: Bachmann Thomas , Bernau Marla Jil 
Published: December 2024

ZusammenfassungIn der vorliegenden Studie wird untersucht, ob Coaches sich in ihrer wahrgenommenen Grandiosität als Facette des Narzissmus signifikant von der Normalbevölkerung unterscheiden und welche Variablen Grandiosität prädiktieren. Es wurden Daten von 559 Teilnehmern der Coaching-Umfrage Deutschland des Jahres 2022 analysiert. Grandiosität wurde mithilfe von Items der deutschen Kurzversion des Narcissistic Personal Inventory (NPI-d-5) ermittelt. Die Ergebnisse zeigen, dass Coaches signifikant höhere Ausprägungen hinsichtlich der Grandiosität aufweisen als die Normalbevölkerung. Gleichzeitig zeigen sich verschiedene Zusammenhänge zwischen Grandiosität, Gender, Alter, Coaching-Erfahrung.
Impact of land transformation, management and governance on subjective wellbeing across social–ecological systems
Authors: Santillán-Carvantes Patricia , Tauro Alejandra , Balvanera Patricia , Requena-Mullor Juan Miguel , Castro Antonio J. , Quintas-Soriano Cristina , Martín-López Berta 
Published: December 2024

AbstractRecognizing and understanding the subjective wellbeing (SWB) of individuals is essential for designing effective policies that promote human development and the sustainable management of social-ecological systems (SES). This is particularly important for smallholders, critical stewards of biodiversity who face acute livelihood challenges. This article explores how smallholders inhabiting tropical dry forests in Mexico perceive their SWB and how it changes across a spectrum of SES that undergo different land transformations, management intensities, and governance dynamics. Our aims are to identify the dimensions of SWB that smallholders perceive, understand how these dimensions change across SES, and examine how smallholders’ perceptions of fulfilled material and non-material dimensions vary across SES. We analyzed the content of 25 in-depth interviews with farmers and identified 48 SWB items belonging to six categories: (1) social capital, (2) economic capital, (3) agency, (4) nature, (5) pleasant non-work activities, and (6) governmental services, and two additional dimensions referred to obstacles and enablers. We found two prevailing visions of SWB: ‘living well’ prevails especially in areas with communal governance and medium management intensity, and ‘need to earn more’ prevails in areas with individual governance and intensified land management. As management is intensified and governance fosters individualism, the lower the self-perceived material and non-material satisfaction. We discuss the different SWB found per SES, as well as strategies that can foster smallholder’s SWB and SES dynamics that can motivate different conservation goals and sustainable uses of nature, especially in biodiverse areas.
NCF-1 plays a pivotal role in the survival of adenocarcinoma cells of pancreatic and gastric origins
Authors: Furuya-Ikude Chiemi , Kitta Akane , Tomonobu Naoko , Kawasaki Yoshihiro , Sakaguchi Masakiyo , Kondo Eisaku 
Published: December 2024

AbstractReactive oxygen species (ROS) play a pivotal biological role in cells, with ROS function differing depending on cellular conditions and the extracellular environment. Notably, ROS act as cytotoxic factors to eliminate infectious pathogens or promote cell death under cellular stress, while also facilitating cell growth (via ROS-sensing pathways) by modifying gene expression. Among ROS-related genes, neutrophil cytosolic factor-1 (NCF-1; p47phox) was identified as a ROS generator in neutrophils. This product is a subunit of a cytosolic NADPH oxidase complex activated in response to pathogens such as bacteria and viruses. NCF-1 has been examined primarily in terms of ROS-production pathways in macrophages and neutrophils; however, the expression of this protein and its biological role in cancer cells remain unclear. Here, we report expression of NCF-1 in pancreatic and gastric cancers, and demonstrate its biological significance in these tumor cells. Abundant expression of NCF-1 was observed in pancreatic adenocarcinoma (PDAC) lines and in patient tissues, as well as in gastric adenocarcinomas. Accumulation of the protein was also detected in the invasive/metastatic foci of these tumors. Unexpectedly, BxPC-3 underwent apoptotic cell death when transfected with a small interfering RNA (siRNA) specific to NCF-1, whereas the cells treated with a control siRNA proliferated in a time-dependent manner. A similar phenomenon was observed in HSC-58, a poorly differentiated gastric adenocarcinoma line. Consequently, the tumor cells highly expressing NCF-1 obtained coincident accumulation of ROS and reduced glutathione (GSH) with expression of glutathione peroxidase 4 (GPX4), a quencher involved in ferroptosis. Unlike the conventional role of ROS as a representative cytotoxic factor, these findings suggest that NCF-1-mediated ROS generation may be required for expansive growth of PDAC and gastric cancers.
DC Ferrochrome Smelting: The Arcing Zone and Its Influence on Energy Transport and Exergy Dissipation
Authors: Oterdoom Harmen , Reuter Markus , Zietsman Johan 
Published: December 2024

Abstract
Phenomena between the electrode tip, the arc attachment zone (AAZ), and the bath below the AAZ—taken together as arc attachment volume (AAV)—have a significant impact on the performance and efficiency of DC arc furnaces. This paper investigates the phenomena in the AAV in detail. Phenomena are analyzed with reference to industrial scale furnace viz. a Kazakh DC ferrochrome furnace. The impact of the various reactions in the AAV under different conditions both from an energy and exergy flow perspective is analyzed. The temperature, carbon in feed (thus the carbon to feed ratio called RC), and slag from the slag bath are investigated as the significant variables affecting phenomena in the AAV. Results show that alloy can become the reductant to fume specifically Mg(g), SiO(g), Cr(g) and even Fe(g) from slag containing MgO

$$\text{SiO}_{2}$$

SiO
2

, FeO

$$_{x}$$

x

and

$$\text{Cr}_{2}\text{O}_{3}$$

Cr
2

O
3

. The implications and resulting mass and energy transfer by these fumes can play a significant role in understanding open-bath ferrochrome smelting better as well as the energy balance of the arc and its impact on overall furnace efficiency. The irreversibility of the fuming reactions and reoxidation of metal vapor has a significant negative impact on furnace operation if the temperature in the AAV is not managed well due to poor operation regarding charging of feed. This implies not only that the average slag and metal temperature are of importance, but especially the actual AAV temperature is crucial. To fully understand the effect of chemical potential of the gases coming from the AAV, an exergy analysis uniquely showed that the fumes can be essential to reduce energy consumption if managed well, especially if the chemical potential energy can be harnessed in other zones within the furnace. This investigation is also relevant to other open-bath processes with fumable oxides, for example in smelting of ferronickel, titania slag, direct reduced iron, or even iron ore. Understanding the reaction mechanisms in the AAV in detail will be significant to push efficiencies of these applications to their thermodynamic, kinetic, and technological limits to ensure that their green metallurgical impact is fully realized.
Diagnosis, treatment, and follow-up of patients with hypophosphatasia
Authors: Cárdenas-Aguilera Juan Guillermo , González-López Vladimir , Zarante-Bahamón Ana María , Prieto-Rivera Juan Carlos , Baquero-Rodríguez Richard , Chacón-Acevedo Kelly Rocío , Meza-Martínez Adriana Isabel , Serrano-Gayubo Ana Katherina , Medina-Orjuela Adriana , Cáceres-Mosquera Jimena Adriana , Guerrero-Tinoco Gustavo Adolfo , García-Rueda María Fernanda , Guarnizo-Zuccardi Pilar , Herrera-Ortiz Gilberto , Rojas-Barrera Carolina , Carrascal-Guzmán Martha Isabel , Reina-Ávila María Fernanda , Arguinzoniz-Valenzuela Sletza Lissette , Belmont-Martínez Leticia , del-Pino Mariana , Viterbo Gisela Lorena , Seijo Mariana , Calzada-Hernández Joan , Guerra-Hernández Norma Elizabeth , Brunetto Oscar Héctor 
Published: December 2024

Abstract

Introduction
Hypophosphatasia is a rare inherited systemic metabolic disorder, with an estimated prevalence in the severe forms of the disease of 1/100.000–1/300.000, that affects the typical architecture of bone, leading to defective mineralization during growth and remodeling. It is characterized by loss-of-function variants in the ALPL gene, resulting in low activity of tissue-nonspecific alkaline phosphatase. In severe cases, it can be fatal.

Objective
To generate recommendations on the diagnosis, treatment, and follow-up of patients with hypophosphatasia based on available evidence.

Materials and methods
A search for evidence published between 2012 and 2024 was carried out in Medline and Embase. The search was expanded with information from various sources, including official sites of development groups, consensuses, technology evaluations, Google Scholar, clinical experts, and reference lists. The quality of the evidence was evaluated according to the type of document type. A modified Delphi consensus process was carried out with external experts, apart from the development group, it was established an 80% agreement threshold to define the final recommendations.

Results
Sixty-one papers were found in the evidence search. The global quality of the evidence was low. In addition, a consensus was reached on 94 recommendations regarding diagnosis, treatment, and follow-up. Those recommendations were approved by external clinical experts from Colombia, Argentina, Spain, and Mexico.

Conclusions
The recommendations proposed in this document are based on the evidence available to the date the search was carried out, and the judgment of clinical experts. The recommendations on diagnosis, treatment, and follow-up are expected to guide the daily clinical practice for patients with HPP.
Pentagonia plicatifolia (Rubiaceae, Dialypetalantheae) a new species from the Middle Magdalena Valley of Colombia, with a key for the Colombian species of the genus
Authors: Majín-Ladino Andrés F. , Jaramillo M. Alejandra , Aymard Gerardo A. 
Published: December 2024

AbstractWe describe and illustrate Pentagonia plicatifolia A.F.Majín-L. & M.A.Jaram, a new species from the foothills and wet montane forest remnants (at elevations of 300–1,240 m) at Serranía de Las Quinchas, a region located in the Middle Magdalena Valley (the easternmost part of the Chocó Region), in the western slopes of the Eastern Cordillera of Colombia (Boyacá department). We compared this new taxon with morphologically similar species by leaf characters (color and shape) and flower size. Colombia is the country with the largest number of Pentagonia species, likely because three important centers of diversification converge: the tropical Andes, the Chocó region, and the northwestern Amazon. A key to the 22 Pentagonia species occurring in Colombia is also presented.
Fragebogen zu subjektiven Beschwerden im Muskel-Skelett-System – Anpassungen in leichter Sprache
Authors: Ohlendorf Daniela , Schultz Eva , Kullmann Mirjam , Gaum Christian , Bredereck Bettina , Heim Christopher , Weber Britta , Ellegast Rolf , Groneberg David A. , Holzgreve Fabian 
Published: December 2024

Zusammenfassung
Einleitung
In wenigen Studien konnte gezeigt werden, dass Menschen mit Behinderungen oder gesundheitlichen Beeinträchtigungen eine erhöhte Prävalenz für Muskel-Skelett-Erkrankungen aufweisen. Problematisch ist in diesem Zusammenhang das Erhebungsverfahren. Aufgrund der fehlenden Übertragbarkeit war es erforderlich, durch leichte Sprache und unterstützende Kommunikation einen Fragebogen zu entwickeln, der an die Bedürfnisse von Beschäftigten mit Behinderung (die u. a. in Inklusionsbetrieben arbeiten) bzw. Menschen mit geringem Bildungsgrad oder schlechten Deutschkenntnissen angepasst ist. Dieser Fragebogen zielt auf die Erfassung möglicher subjektiver Beschwerden im Muskel-Skelett-System, deren Ursachen und der Erfassung von Arbeitsbeeinträchtigung ab.

Methoden
Als Vorlage des Fragebogens zu subjektiven Beschwerden im Muskel-Skelett-System bei Menschen mit Behinderung diente hauptsächlich die deutsche Version des Nordic Musculoskeletal Questionnaire der Bundesanstalt für Arbeitsschutz und Arbeitsmedizin (BAuA). Zudem wurden Elemente aus dem Deutschen Schmerzfragebogen und dem Multidimensionalen Schmerzfragebogen im professionellen Tanz ergänzend hinzugefügt. Der neue Fragebogen wurde auf Grundlage eines kognitiven Interviews mit 5 Proband*innen mit psychischer Behinderung entwickelt. Dabei wurde auf folgende kognitive Techniken zurückgegriffen: Nachfragen zum Verständnis, Nachfragen zum Besitz relevanter Informationen und Sortiertechnik.

Ergebnisse
Die deutsche Version des Nordic Musculoskeletal Questionnaire wurde in leichte Sprache übersetzt und durch eine vergrößerte Darstellung sowie die Kennzeichnung der Vorder- und Rückseite der abgebildeten Menschen angepasst. Zusätzlich wurden alle Abbildungen durch einen erklärenden Satz ergänzt. Außerdem wurden Fragen über die Dauer, Ursache und den Umgang mit Beschwerden bei der Arbeit aus dem Deutschen Schmerzfragebogen und dem Multidimensionalen Schmerzfragebogen im professionellen Tanz verwendet sowie durch Reduktion von Antwortmöglichkeiten gekürzt.

Diskussion
Der Fragebogen wurde an die Bedürfnisse von Menschen mit Behinderung (u. a. Mitarbeitende in Inklusionsbetrieben) bzw. Menschen mit geringem Bildungsgrad oder schlechten Deutschkenntnissen angepasst. Da die Vielfalt der Behinderungen und deren Grade bei Beschäftigten mit Behinderung variieren, ist demnach die allgemeine Anwendbarkeit des Fragebogens limitiert. Die gewonnenen Erkenntnisse können dazu dienen, speziell angepasst Gesundheitsfördermaßnahmen zu entwickeln und langfristig die Gesundheit zu verbessern.
The relationship between ethics and innovation: specifically regarding the application and ethical considerations of artificial intelligence in animal models
Authors: Yin Hong , Li Qiannan , Yang Shuling , Zhang Chunhuan , Zhai Yueyi , Hou Haowei , Qu Yan 
Published: December 2024

Abstract
Objective
To examine the role of animal models in tumor research, the ethical issues surrounding their use, and the potential of artificial intelligence technology in improving animal welfare and addressing ethical concerns.

Methods
This paper reviews the role of animal models in cancer research and considers the ethical issues surrounding their use. The various types and applications of animal models used in cancer research, as well as the controversy surrounding the use of experimental animals and the potential and feasibility of AI in improving animal welfare and addressing ethical issues, were examined in detail.

Results
Tumor animal models are a valuable research tool for advancing our understanding of tumor formation and for evaluating the efficacy of therapeutic approaches. The implementation of AI has the potential to diminish or supplant the necessity for animal experimentation, enhance the precision and credibility of research outcomes, and address ethical concerns.

Conclusion
Animal models are very important in tumor research, and they should be combined with the development of science and technology to improve animal welfare and relieve ethical pressure.
The rural health initiative: Bridging gaps in healthcare access and grant-funded research in central Idaho
Authors: Zigman Suchsland Monica , van Rensburg Dillon , McGrath Kelly , Wilkinson Cody , Johnson Kimberly , Steinbruecker Ashley , Probus James , Cole Allison 
Published: December 2024

Abstract

Introduction:
Translational science rarely addresses the needs of rural communities, perpetuating health inequities. Furthermore, policy and resource allocation reflect this dynamic. Through a partnership between a rural community and a community engagement program, the Rural Health Initiative (RHI) was developed with the goal of building capacity for community-driven translational research in rural settings.

Methods:
We describe the process of forming the RHI and selection of a community health priority to motivate the translational research agenda in this particular rural setting. We used a mixed methods approach utilizing literature review, community survey data, and qualitative evaluation of community meeting discussions. Consensus on a final health priority was built through voting and comparison of voting responses across the three RHI counties through Fisher’s Exact test.

Results:
Four priority topics were identified through literature search, community needs assessment, state/national trend data, and community experts. Priority ranking from a community forum and survey selected the final health priority topic. Healthcare access was selected by all three counties in the RHI community as the most critical health priority to address.

Conclusions:
This program highlights the importance of and methods for community involvement in directing the research conducted in their community. Additionally, through this project, guidance was developed to define the role of community engagement programs supporting work led by communities.