bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peripheral Primitive Neuroectodermal Tumor: Challenge for Multimodal Treatment
Authors: Zimmermann Thomas , Blütters‐Sawatzki Renate , Flechsenhar Klaus , Padberg Winfried M. 
Published: December 2019

The primitive neuroectodermal tumor
(PNET) is an extremely aggressive soft tissue neoplasm that occurs in children and adolescents. We retrospectively reviewed our therapeutic experience with a multidisciplinary approach, combining surgery,
chemotherapy, and radiation therapy. Treatment of PNET was carried out in compliance with the soft tissue protocol (CWS) from the German Society of Pediatric Oncology. Biopsy‐proven diagnosis was followed by chemotherapy, which in all cases led to partial remission, allowing excision of the remainder of the tumor without mutilation. After excision, irradiation of the tumor site and two further sequences of chemotherapy were performed. When PNET of the paravertebral region caused symptoms of paralysis and immediate surgery was required,
postoperative chemotherapy, a second‐look operation, and irradiation were undertaken. Between 1986 and 1998 we treated 13 patients (median age 15 years). In five patients the PNET originated from the chest wall and in eight patients from the paravertebral and retroperitoneal region. Five patients died after 20 months on average, and the remaining eight patients are in full remission after 7, 16, 46, 55, 70,
74, 75, and 115 months, respectively. Close cooperation between surgeons and their pediatric and radiotherapy colleagues is obligatory when treating PNET. Chemotherapy as the first stage is mandatory to avoid a mutilating surgical procedure and intraoperative tumor cell dissemination.
Reflections on the 50th Anniversary of the First Abdominal Aortic Aneurysm Resection
Authors: Cervantes Jorge 
Published: December 2019

AbstractFifty years ago, on March 29, 1951, Charles Dubost in France performed the first successful resection of an abdominal aortic aneurysm and replaced it with a cadaver homograft, thereby initiating the modern era of surgical correction of a common entity. This article offers a summary of the events leading to that milestone in vascular surgery.
War Injuries of Major Extremity Arteries
Authors: Nanobashvili Joseph , Kopadze Teimuraz , Tvaladze Merab , Buachidze Teimuraz , Nazvlishvili Georgi 
Published: December 2019

AbstractDuring the period 1991–1994, 99 patients (all males, median age 35 years) with combat‐related injuries of major limb arteries were managed. Mechanism: mine fragments (40%), high‐velocity projectiles (35%), and shotgun pellets (25%). Patients were admitted 1 hour to 16 hours (median 8 hours) after injury; 39% were in severe hemorrhagic shock. Arterial injury was diagnosed by clinical findings. Preoperative angiography was usually not necessary. Of 99 injured patients, 50 (51%) showed signs of distal ischemia and required arterial reconstruction. No primary amputation was performed. Reconstruction was always necessary in cases of injury of axillary or popliteal arteries, but not of superficial femoral or brachial arteries. Ligation of injured single forearm or crural arteries was well tolerated. End‐to‐end anastomosis by reconstruction was possible only in 38% of cases. In 56% of patients, autologous venous bypass was performed. Uncontrolled wound infection developed in 22% of cases, leading to a secondary hemorrhage compelling arterial ligature (8%), and thrombosis (6%). The secondary amputation rate after arterial reconstruction was 10%. Injury of major vessels was associated with limb bone fractures, nerve damage, or major vein injuries in 68% of cases, frequently on the forearm, the popliteal region, and the crural region. When limb ischemia was present, vascular reconstruction had priority over orthopedic immobilization. Arterial injury was almost always associated with the venous damage in the forearm, the popliteal region, and the crural region. Injured veins of the upper limb were ligated; venous repair was more often indicated in lower limb injury (52%). The method of choice was lateral suture/patch. Gunshot damage to peripheral nerves was rarely treated with primary repair.
Limited Surgery and Tamoxifen in the Treatment of Elderly Breast Cancer Patients
Authors: Odendaal J. de V. , Apffelstaedt J.P. 
Published: December 2019

AbstractA conservative approach to treating breast cancer patients was adopted for those more than 70 years of age with T1‐3 and small localized T4b N0‐1 lesions. It consists of tumor excision or simple mastectomy with adjuvant tamoxifen. From the prospective breast cancer database, patients 70 years or older at the time of diagnosis were identified for the period January 1990 to December 1996. Demographic, clinical, pathological, and oncologic data were retrieved. A total of 236 patients were identified. Ninety‐seven patients (41%) were treated according to the conservative protocol. Of these, 74 had a tumor excision and 23 had a simple mastectomy. Their mean age was 79 years. TNM staging was stage I in 18 patients, stage II in 66 patients, and stage III in 13 patients. There was no 30‐day mortality. Eleven patients were not compliant with tamoxifen use. Two patients were lost to follow‐up. The mean follow‐up is 51 months (range 4 to 109 months). The cumulative incidence of local and regional recurrence at 8 years is 5% and 7%, respectively. Locoregional recurrences were controlled with excision, mastectomy, or axillary dissection. The cumulative disease‐specific, overall, and disease‐free survival at 5 years is 86%, 64% and 46%, respectively. Tumor excision or simple mastectomy with tamoxifen offers sufficient tumor control for elderly patients. Axillary dissection and breast or chest wall radiotherapy can safely be omitted, thereby greatly reducing health care resource utilization.
Snakebites in the Rainforests of Ecuador
Authors: Praba‐Egge Anita D. , Cone Stephen W. , Araim Omar , Freire L. Isabel , Paida V. Galo , Escalante T. Johnny , Carrera M. Favio , Chavez R. Mirian , Merrell Ronald C. 
Published: December 2019

AbstractEpidemiologic information about snakebites in Ecuador is scarce. Snakebites are more common in the lowlands east of the Andes, in the Amazon basin. In the present study, a retrospective review of all (n = 142) snakebite admissions to Hospital Pio XII, a regional health center/hospital in the canton of Sucúa, Morona Santiago, Ecuador was carried out between the years of 1996 and 2000. Bites occurred more frequently during the months of March to May. The largest group of patients were in the 15‐ to 49‐year‐old range (52.5%), and agricultural workers were the most affected of all patients by occupation (> 40%). In most cases of snakebite, patients could not identify the type of snake that had bitten them. A small number of patients (n = 60, 42.3%) received some type of treatment prior to arrival at the hospital. Bites occurred most frequently on the left lower extremity (31.7%). Typical symptoms included pain and local edema at the snakebite site; generalized symptoms such as fever, nausea, and vomiting were less frequent. Most patients (almost 90%) received antivenin during hospitalization in addition to supportive care. The mean hospital stay was 4.3 days. More than 90% of all 142 patients recovered, about 8% with local abscesses. Mortality was 2.9% and occurred as a result of complications, including renal failure, respiratory failure, and disseminated intravascular coagulation.
Impact of Seasonal and Temperature-Dependent Variation in Root Defense Metabolites on Herbivore Preference in Taraxacum officinale
Authors: Huang Wei , Bont Zoe , Hervé Maxime R. , Robert Christelle A. M. , Erb Matthias 
Published: December 2019

AbstractPlants experience seasonal fluctuations in abiotic and biotic factors such as herbivore attack rates. If and how root defense expression co-varies with seasonal fluctuations in abiotic factors and root herbivore attack rates is not well understood. Here, we evaluated seasonal changes in defensive root latex chemistry ofTaraxacum officinaleplants in the field and correlated the changes with seasonal fluctuations in abiotic factors and damage potential byMelolontha melolontha, a major natural enemy ofT. officinale. We then explored the causality and consequences of these relationships under controlled conditions. The concentration of the defensive sesquiterpene lactone taraxinic acid β-D glucopyranosyl ester (TA-G) varied substantially over the year and was most strongly correlated to mean monthly temperature. Both temperature and TA-G levels were correlated with annual fluctuations in potentialM. melolonthadamage. Under controlled conditions, plants grown under high temperature produced more TA-G and were less attractive forM. melolontha. However, temperature-dependentM. melolonthafeeding preferences were not significantly altered in TA-G deficient transgenic lines. Our results suggest that fluctuations in temperature leads to variation in the production of a root defensive metabolites that co-varies with expected attack of a major root herbivore. Temperature-dependent herbivore preference, however, is likely to be modulated by other phenotypic alterations.
Occurrence of anticancer drugs in the aquatic environment: a systematic review
Authors: Nassour Carla , Barton Stephen J. , Nabhani-Gebara Shereen , Saab Yolande , Barker James 
Published: December 2019

AbstractWater contamination with pharmaceutical products is a well-studied problem. Numerous studies have demonstrated the presence of anticancer drugs in different water resources that failed to be eliminated by conventional wastewater treatment plants. The purpose of this report was to conduct a systematic review of anticancer drugs in the aquatic environment. The methodology adopted was carried out in compliance with the PRISMA guidelines. From the 75 studies that met the specific requirements for inclusion, data extracted showed that the most common anticancer drugs studied are cyclophosphamide, tamoxifen, ifosfamide and methotrexate with concentrations measured ranging between 0.01 and 86,200 ng/L. There was significant variation in the methodologies employed due to lack of available guidelines to address sampling techniques, seasonal variability and analytical strategy. The most routinely used technique for quantitative determination was found to be solid-phase extraction followed by LC-MS analysis. The lowest reported recovery percentage was 11%, and the highest limit of detection was 1700 ng/L. This indicated the inadequacy of some methods to analyse anticancer drugs and the failure to obtain reliable results. The significant heterogeneity within methodologies made it difficult to compare results and draw conclusions, nevertheless, this study aids in the extrapolation of proposed recommendations to guide future studies and reviews.
Adding Fuel to the Flames? Politicisation of EU Policy Evaluation in National Parliaments
Authors: Hoerner Julian M. 
Published: December 2019

AbstractUnder which conditions does national parliamentary discourse politicise European Union (EU) policy evaluation? In times of multiple crises and uncertainty, the alleged ‘democratic deficitʼ of the EU, defined as an apparent lack of legitimacy, has regained scholarly and popular attention. The European Commission and academic commentators consider policy evaluation a specialised and targeted tool to improve the ‘output legitimacyʼ of the EU by assessing policy effectiveness and efficiency. While evaluation can strengthen output legitimacy directly via learning, evaluation can be particularly effective when it becomes part of the national communicative discourse on the EU. This discourse is most likely to take place in national parliaments, as they are the forums in which the government can be held to account. This paper relies on an automated content analysis of the share of keywords related to EU policy evaluation in debates in six national parliaments, covering a period of 20 years. The findings show that the combination of popular and party Euroscepticism is crucial in determining parliamentary debate on EU policy evaluation. Pro-European parties generally do not refer to policy evaluation. However, if political parties are critical of European integration, EU policy evaluation is mentioned more frequently. Under these conditions, members of parliaments also refer more frequently to EU policy evaluation as the public becomes more Eurosceptic. These findings suggest that EU policy evaluation is used as a tool for domestic political contestation, with potential negative normative implications for the output legitimacy of the EU and for evaluation as a tool for learning.
The (in)Significance of the Addiction Debate
Authors: Goldberg Anna E. 
Published: December 2019

AbstractSubstance addiction affects millions of individuals worldwide and yet there is no consensus regarding its conceptualisation. Recent neuroscientific developments fuel the view that addiction can be classified as a brain disease, whereas a different body of scholars disagrees by claiming that addictive behaviour is a choice. These two models, the Brain Disease Model and the Choice Model, seem to oppose each other directly. This article contends the belief that the two models in the addiction debate are polar opposites. It shows that it is not the large amount of addiction research in itself what sets the models apart, but rather their extrapolated conclusions. Moreover, some of the most fiercely debated aspects - for instance, whether or not addiction should be classified as a disease or disorder - are irrelevant for the conceptualisation of addiction. Instead, the real disagreement is shown to revolve around capacities. Discussing addiction-related capacities, especially regarding impaired control, rather than the assumed juxtaposition of the two models can be considered the true addiction debate. More insight into the extent to which the capacities of the addicted individual were affected would be highly useful in various other areas, especially legal responsibility.
Reduced graphene oxide-intercalated graphene oxide nano-hybrid for enhanced photoelectrochemical water reduction
Authors: Aragaw Belete Asefa 
Published: December 2019

Abstract
This paper reports on the synthesis of reduced graphene oxide (RGO)-intercataled graphene oxide (GO) nano-hybrid and investigates its application in photoelectrochemical (PEC) water reduction. The optical, structural, and morphological properties of RGO-intercalated GO (RGO/GO) nano-hybrid were studied using UV–Visible spectroscopy, X-ray diffraction, and scanning electron microscopy, respectively. The reduction of GO to RGO was studied using FTIR spectroscopy. The XRD and FTIR investigation shows the strong π–π stacking interactions between the layered GO host–RGO guest sheets. An improvement in PEC water reduction activity was exhibited by RGO/GO nano-hybrid photoelectrode, with a maximum photocurrent of − 61.35 μA/cm2 for RGO 1 wt% in GO versus − 42.80 μA/cm2 for pristine GO photoelectrode (43% improvement). The mechanism for photocurrent enhancement was studied by electrochemical impedance analysis. The PEC performance enhancement of RGO/RO nano-hybrid photoelectrode is attributed to the strong π–π stacking interactions between RGO and GO, leading to superior electron collection and transportation by RGO and hence reduced charge carrier recombination. In addition, the UV–Visible absorption and Taut plot analysis showed the higher light harvesting efficiency of the RGO/GO compared to GO, displaying a band gap of 2.58 eV and 3.11 eV for RGO/GO and GO, respectively. The findings of this work show the potential of a strongly coupled layered host–guest nano-hybrids for high-performance optoelectronic materials.

Graphic abstract
TWO NEW SERIES OF PRINCIPLES IN THE INTERPRETABILITY LOGIC OF ALL REASONABLE ARITHMETICAL THEORIES
Authors: GORIS EVAN , JOOSTEN JOOST J. 
Published: December 2019

AbstractThe provability logic of a theory T captures the structural behavior of formalized provability in T as provable in T itself. Like provability, one can formalize the notion of relative interpretability giving rise to interpretability logics. Where provability logics are the same for all moderately sound theories of some minimal strength, interpretability logics do show variations.The logic IL (All) is defined as the collection of modal principles that are provable in any moderately sound theory of some minimal strength. In this article we raise the previously known lower bound of IL (All) by exhibiting two series of principles which are shown to be provable in any such theory. Moreover, we compute the collection of frame conditions for both series.
Two challenges for a dual system approach to temporal cognition
Authors: De Brigard Felipe , O'Neill Kevin 
Published: December 2019

Abstract
Hoerl & McCormack (H&M) propose a two-system account of temporal cognition. We suggest that, following other classic proposals where cognitive systems are putatively independent, H&M's two-system hypothesis should, at a minimum, involve (1) a difference in the nature of the representations upon which each system operates, and (2) a difference in the computations they carry out. In this comment we offer two challenges aimed at showing that H&M's proposal does not meet the minimal requirements (1) and (2).
Blood purity and scientific independence: blood science and postcolonial struggles in Korea, 1926–1975
Authors: Hyun Jaehwan 
Published: December 2019

ArgumentAfter World War II, blood groups became a symbol of anti-racial science. This paper aims to shed new light on the post-WWII history of blood groups and race, illuminating the postcolonial revitalization of racial serology in South Korea. In the prewar period, Japanese serologists developed a serological anthropology of Koreans in tandem with Japanese colonialism. The pioneering Korean hematologist Yi Samyŏl (1926–2015), inspired by decolonization movements during the 1960s, excavated and appropriated colonial serological anthropology to prove Koreans as biologically independent from the Japanese. However, his racial serology of Koreans shared colonial racism with Japanese anthropology, despite his anti-colonial nationalism.
Defining and Operationalizing Disaster Preparedness in Hospitals: A Systematic Literature Review
Authors: Verheul Marlous LMI , Dückers Michel LA 
Published: December 2019

AbstractIntroduction:Societies invest substantial amounts of resources on disaster preparedness of hospitals. However, the concept is not clearly defined nor operationalized in the international literature.Aim:This review aims to systematically assess definitions and operationalizations of disaster preparedness in hospitals, and to develop an all-encompassing model, incorporating different perspectives on the subject.Methods:A systematic search was conducted in five databases: Scopus, PubMed, Web of Science, Disaster Information Management Research Centre, and SafetyLit. Peer-reviewed articles containing definitions and operationalizations of disaster preparedness in hospitals were included. Articles published in languages other than English, or without available full-text, were excluded, as were articles on prehospital care. The findings from literature were used to build a model for hospital disaster preparedness.Results:In the included publications, 13 unique definitions of disaster preparedness in hospitals and 22 different operationalizations of the concept were found. Although the definitions differed in emphasis and width, they also reflected similar elements. Based on an analysis of the operationalizations, nine different components could be identified that generally were not studied in relation to each other. Moreover, publications primarily focused on structure and process aspects of disaster preparedness. The aim of preparedness was described in seven articles.Discussion/Conclusion:This review points at an absence of consensus on the definition and operationalization of disaster preparedness in hospitals. By combining elements of definitions and components operationalized, disaster preparedness could be conceptualized in a more comprehensive and complete way than before. The model presented can guide future disaster preparedness activities and research.
Visual and Autonomous Survey of Hydrothermal Vents Using a Hovering‐Type AUV: Launching Hobalin Into the Western Offshore of Kumejima Island
Authors: Okamoto Akihiro , Seta Takahiro , Sasano Masahiko , Inoue Shunji , Ura Tamaki 
Published: December 2019

AbstractAutonomous underwater vehicles (AUVs) have become promising tools for marine geological surveys to collect information such as the topography of the seafloor and the location of hydrothermal plumes. Visual surveys and sampling are mainly conducted using human‐occupied vehicles or remotely operated vehicles. To obtain detailed visual data more efficiently, a hovering‐type AUV (Hobalin), which has the novel ability to autonomously navigate within a vent field, was developed to explore hydrothermal deposits. This vehicle was deployed in an active hydrothermal vent field located in the western offshore of Kumejima Island at a depth of approximately 1,400 m. Visual observations were performed with submillimeter image resolution via low‐altitude navigation using still cameras. Moreover, a height estimation method for chimney structures was proposed utilizing an obstacle avoidance system composed of a sheet laser and a forward‐looking camera with hovering maneuver capability. It was determined that hovering‐type AUVs can facilitate the effective survey of hydrothermal vents and the acquired data can be utilized for subsequent sampling by human‐occupied vehicles and remotely operated vehicles.
Using Rigid Microplate Motions to Detect the Stress Buildup Preceding Large Earthquakes: A Feasibility Test Based on Synthetic Models
Authors: Martin de Blas Juan , Iaffaldano Giampiero 
Published: December 2019

AbstractAssessing the temporal evolution of stresses along seismogenic faults is typically done by combining geodetic observations collected near the locations of previous large earthquakes with modeling of the interseismic, coseismic, and postseismic deformation. Here we explore whether it is feasible to link the charge phase of large earthquakes to rigid microplate motions, which can be inferred from geodetic observations that are instead collected further away from crustal faults. We use numerical simulations of the dynamics and associated kinematics of an idealized, rigid microplate subject to stress buildups and drop‐offs from a series of earthquakes. Simulations span the charging cycle of a single
earthquake. Several
earthquakes distributed according to the Gutenberg‐Richter law occur meanwhile. We use large ensembles of simulations featuring randomly‐generated earthquake hypocenters and make statistical assessments of the fraction of model time needed for the microplate motions to depart from the initial one to a degree that is larger than typical geodetic uncertainties and for at least 90% of the remaining time before the large earthquake occurs. We find such a fraction (i) to be only one tenth in simulations that do feature a large earthquake, (ii) to be longer in simulations that do not, and (iii) to remain small for realistic microplate geometries and asthenosphere viscosity/thickness values. Our inferences hold also when we simulate geodetic time series shorter than the large earthquake cycle and even when we assume that only half of the stress buildup affects the microplate rigid motion.