bluuebunny/crossref_metadata_2025_split huggingface dataset:
Teacher´s role in the meaningful learning achievement based on ICT
Authors: Gómez Vahos Luz Estela , Muriel Muñoz Luz Enid , Londoño-Vásquez David Alberto 
Published: November 2019

En este artículo se analizan el papel del docente que busca en los estudiantes el desarrollo de competencias, como las formuladas por la didáctica crítica para el desarrollo de los conocimientos, habilidades y valores, las cuales se deben apoyar en el buen uso de las Tecnologías de Información y Comunicación, para así facilitar un aprendizaje que le sea significativo y útil en su contexto familiar, social y laboral; de igual forma, invita a la discusión sobre como desde las prácticas educativas se accede a la construcción del conocimiento de una forma crítica, argumentativa, propositiva y comunicativa, donde los intereses de cada sujeto que interviene en el proceso educativo, se centra en el aprendizaje. Asimismo, se expone el papel del docente en el desarrollo del aprendizaje significativo con el acercamiento al conocimiento que permiten hoy los medios de comunicación y de información, con la cual se pretende afianzar el proceso de enseñanza aprendizaje desde los intereses, necesidades y oportunidades que presenta el contexto.
Ortaya Çıkan Modelleme Yaklaşımıyla Kavramlaştırma Süreci: Sembolleştirme Örneği
Authors: TURAL SÖNMEZ Melike 
Published: November 2019

Bu çalışmada üçüncü
sınıf öğrencisinin ortaya çıkan modelleme yaklaşımı ile matematiksel sembolleri
kullanma süreci ortaya çıkarmak amaçlanmıştır. Ön uygulama yapılmış, adından
belirli amaca göre üçüncü sınıf öğrencisi katılımcı olarak seçilmiştir.
Araştırma fenemolojik durum çalışması niteliğindedir. Uygulanan etkinlikler bir
öğrenci ile dört ay aralıkla uygulanan model oluşturma ve model adaptasyon
etkinliklerinden oluşmaktadır. Araştırmada veri toplama araçları modelleme
sürecinde alınan ses kayıtlarından ve dokümanlardan, araştırmacı gözlem
notlarından, öğrenci ve öğrenci velisiyle yapılan görüşmenin ses kaydından ve dokümanlardan
oluşmaktadır. Öğrencinin matematiksel modelleme sürecindeki performansı ele
alındığında bireyin deneyimi nedir? sorusuna cevap aranmıştır ve ortaya çıkan
modelleme perspektifinde ele alınan ‘model
of’ ve ‘model for’ döngüsü içinde
yorumlanmıştır. Yapılan analizler
sonucunda model oluşturma ve model adaptasyon etkinliklerinde öğrencinin
standart ve standart olmayan ölçüm birimleri ile yaptığı ölçümler sonunda
gruplamalar oluşturduğu ve bu gruplandırmaların öğrenciyi parantez kullanmaya
yönelttiğini göstermektedir. Çalışmada öğrencinin standart ve standart olmayan
ölçme birimlerini kullanması ve bunu diğer matematiksel kavramlarla
ilişkilendirilmesi sosyokültürel perspektifle açıklanmıştır.
Traditions of S.T. Coleridge’s ‘The Rime of the Ancient Mariner’ in ‘The Ballad of Reading Gaol’ by O. Wilde
Authors: Zhatkin Dmitry Nikolayevich , Ryabova Anna A. 
Published: November 2019

This article aims to analyse the poetic traditions of The Rime of the Ancient Mariner by S.T. Coleridge, which migrated into The Ballad of Reading Gaol by O. Wilde. A comparative analysis of original poems and their Russian translations reveals a thematic and structural link that connects these two poems. The article highlights the common features and the differences in literary devices used by Coleridge and Wilde to transmit the complex concepts of suffering and forgiveness through their characters and to declare values and philosophical ideas. The literary devices in point define how these concepts are covered, and serve a common theme in the work of Coleridge and Wilde. The article also provides arguments to confirm the social situation described in the works.
The lyrico-epic genre allows using both poetry analysis tools and prose research methods, which ensures high-quality research.
The article frames values of the modern culture and creates conditions for discovering a conceptual similarity in the symbolism of The Rime of the Ancient Mariner and The Ballad of Reading Gaol.
Microsurgery for Brachial Plexus Injury Before Versus After 6 Months of Age
Authors: Bauer Andrea S. , Kalish Leslie A. , Adamczyk Mark J. , Bae Donald S. , Cornwall Roger , James Michelle A. , Lightdale-Miric Nina , Peljovich Allan E. , Waters Peter M. ,   on behalf of the Treatment and Outcomes of Brachial Plexus Injury (TOBI) Study Group
Published: November 2019

Background:
Infants with more severe brachial plexus birth injury (BPBI) benefit from primary nerve surgery to improve function. The timing of the surgery, however, is controversial. The Treatment and Outcomes of Brachial Plexus Injury (TOBI) study is a multicenter prospective study with the primary aim of determining the optimal timing of this surgical intervention. This study compared outcomes evaluated 18 to 36 months after “early” microsurgery (at <6 months of age) with the outcomes of “late” microsurgery (at >6 months of age).

Methods:
Of 216 patients who had undergone microsurgery, 118 were eligible for inclusion because they had had a nerve graft and/or transfer followed by at least 1 physical examination during the 18 to 36-month interval after the microsurgery but before any secondary surgery. Patients were grouped according to whether the surgery had been performed before or after 6 months of age. Postoperative outcomes were measured using the total Active Movement Scale (AMS) score as well as the change in the AMS score. To address hand reinnervation, we calculated a hand function subscore from the AMS hand items and repeated the analysis only for the subjects with a Narakas grade of 3 or 4. Our hypothesis was that microsurgery done before 6 months of age would lead to better clinical outcomes than microsurgery performed after 6 months of age.

Results:
Eighty subjects (68%) had early surgery (at a mean age of 4.2 months), and 38 (32%) had late surgery (at a mean age of 10.7 months and a maximum age of 22.0 months). Infants who underwent early surgery presented earlier in life, had more severe injuries at baseline, and had a significantly lower postoperative AMS scores in the unadjusted analysis. However, when we controlled for the severity of the injury, the difference in the AMS scores between the early and late surgery groups was not significant. Similarly, when we restricted our multivariable analysis to patients with a Narakas grade-3 or 4 injury, there was no significant difference in the postoperative AMS hand subscore between the early and late groups.

Conclusions:
This study suggests that surgery earlier in infancy (at a mean age of 4.2 months) does not lead to better postoperative outcomes of BPBI nerve surgery than when the surgery is performed later in infancy (mean age of 10.7 months).

Level of Evidence:
Prognostic Level II. See Instructions for Authors for a complete description of levels of evidence.
Anterolateral Complex Reconstruction Augmentation of Anterior Cruciate Ligament Reconstruction
Authors: Lau Brian C. , Rames Jess , Belay Elshaday , Riboh Jonathan C. , Amendola Annunziato , Lassiter Tally 
Published: November 2019

» Injury to the anterolateral complex may be identified on advanced imaging and may manifest with a higher level of instability, in particular with pivot-shift testing.» The anterolateral ligament reconstruction or modified Lemaire procedure may be used to reconstruct the anterolateral complex of the knee to augment anterior cruciate ligament (ACL) reconstruction.» Indications for anterolateral ligament reconstruction are evolving, but relative indications include revision ACL reconstruction, grade-III pivot shift, generalized ligamentous laxity, young age (<20 years), or high-level or high-demand athlete.» Early outcomes have suggested that anterolateral ligament augmentation of ACL reconstruction may decrease the risk of re-tear of the ACL reconstruction.
Proteomics profiling and pathway analysis of hippocampal aging in rhesus monkeys
Authors: Meng Shu , Xia Wenchao , Pan Meng , Jia Yangjie , He Zhanlong , Ge Wei 
Published: November 2019

Abstract
Background: Aged rhesus monkeys exhibit deficits in memory mediated by the hippocampus. Although extensive research has been carried out on the characteristics of human hippocampal aging, there is still very little scientific understanding of the changes associated with hippocampal aging in rhesus monkeys. To explore the proteomics profiling and pathway-related changes in the rhesus hippocampus during the aging process, we conducted a high throughput quantitative proteomics analysis of hippocampal samples from two groups of rhesus macaques aged 6 years and 20 years, using 2-plex tandem mass tag (TMT) labeling. In addition, we used a comprehensive bioinformatics analysis approach to investigate the enriched signaling pathways of differentially expressed proteins (the ratios of 20-y vs. 6-y, ≥1.20 or ≤ 0.83). Results: In total, 3,260 proteins were identified with a high level of confidence in rhesus hippocampus. We found 367 differentially expressed proteins related to rhesus hippocampus aging. Based on biological pathway analysis, we found these aging-related proteins were predominantly enriched in the electron transport chain, NRF2 pathway, focal adhesion-PI3K-AKT-mTOR signaling pathway and cytoplasmic ribosome proteins. Data are available via ProteomeXchange with identifier PXD011398. Conclusion: This study provides a detail description of the proteomics profile related to rhesus hippocampal aging. These findings should make an important contribution to further mechanistic studies, marker selection and drug development for the prevention and treatment of aging or age-related neurodegeneration.
The transfer of knowledge on integrated care among five European regions: a qualitative multi-method study
Authors: Grooten Liset , Vrijhoef Hubertus Johannes Maria , Alhambra-Borrás Tamara , Whitehouse Diane , Devroey Dirk 
Published: November 2019

Abstract
Background To examine how the knowledge transfer processes unfolded within SCIROCCO, a EU funded project (3rd Health Programme (2014-2020)) that aimed to facilitate the process of knowledge sharing across five European regions, to speed up adoption and scaling-up of integrated care initiatives.
Methods A qualitative multi-method design was used. Data collection methods included focus groups, project documents and action plans of the regions. The data was analysed using a qualitative content-analysis procedure, which was guided by the frameworks of knowledge exchange and the why, whose, what, how framework for knowledge mobilisers
Results All five components (including the themes) of knowledge exchange could be identified in the approach developed on the knowledge transfer processes. The four questions and accompanying categories of the framework of knowledge mobilisation were also identified to a large degree.
Conclusions The observed incorporation of distinct forms of knowledge from multiple sources and the observed dynamic and fluid knowledge transfer processes both suggest that SCIROCCO developed a comprehensive knowledge transfer approach aiming to enable the adoption and scaling-up of integrated care. Overall, the multi-method qualitative nature of this research has allowed some new and practical insights in the knowledge transfer activities on integrated care between several European regions. To obtain a clear understanding of the content of the knowledge transfer approaches, which could assist the operationalising of models to support the evaluation of knowledge transfer activities, it is strongly recommended that further research of this type should be conducted in other research settings.
Daily Almond Consumption in Cardiovascular Disease Prevention via LDL-C Change in the U.S. Population: a Cost-Effectiveness Analysis
Authors: Author) Jifan Wang(New Corresponding , Bravatti Michelle A. Lee , Johnson Elizabeth J. , Author) Gowri Raman(Former Corresponding 
Published: November 2019

Abstract
Objectives Heart disease is the leading cause of death in the United States. The U.S. Food and Drug Administration approved the health claim that 1.5 ounces (42.5 grams) of nut intake may reduce the risk of cardiovascular disease (CVD). Previous studies have focused on the cost-effectiveness of other foods or dietary factors on primary CVD prevention, yet not in almond consumption. This study aimed to examine the cost-effectiveness of almond consumption in CVD primary prevention.
Perspective & Setting This study assessed the cost-effectiveness of consuming 42.5 grams of almond from the U.S. healthcare sector perspective.
Methods A decision model was developed for 42.5 grams of almond per day versus no almond consumption and CVD in the U.S. population. Parameters in the model were derived from the literature, which included the probabilities of increasing LDL-C, developing acute myocardial infarction (MI) and stroke, treating MI, dying from the disease and surgery, as well as the costs of the disease and procedures in the U.S. population, and the quality-adjusted life years (QALY). The cost of almonds was based on the current price in the U.S. market. Sensitivity analyses were conducted for different levels of willingness-to-pay, the probabilistic sensitivity analysis, ten-year risk prevention, different costs of procedures and almond prices, and patients with or without CVD.
Results The almond strategy had $363 lower cost and 0.02 higher QALY gain compared to the non-almond strategy in the base-case model. The annual net monetary benefit (NMB) of almond consumption was $1,421 higher per person than no almond consumption, when the willingness to pay threshold was set at $50,000 for annual health care expenditure. Almond was more cost-effective than non-almond in CVD prevention in all the sensitivity analyses.
Conclusion Consuming 42.5 grams of almonds per day is a cost-effective approach to prevent CVD in the short term and potentially in the long term.
Integration of mental health care in private not-for-profit health centres in Guinea, West Africa: a systemic entry point towards the delivery of more patient-centred care?
Authors: Sow Abdoulaye , De Man Jeroen , De Spiegelaere Myriam , Vanlerberghe Veerle , Criel Bart 
Published: November 2019

Abstract
Background: Patient-centred care is an essential component of quality of health care. We hypothesize that integration of a mental health care package into versatile first-line health care services can strengthen patient participation, an important dimension of patient-centred care. The objective of this study is to analyse whether consultations conducted by providers in facilities that integrated mental health care score higher in terms of patient participation. Methods: This study was conducted in Guinea in 12 not-for-profit health centres, 4 of which had integrated a mental health care package (MH+) and 8 had not (MH-). The study involved 450 general curative consultations (175 in MH+ and 275 in MH- centres), conducted by 18 care providers (7 in MH+ and 11 in MH- centres). Patients were interviewed after the consultation on how they perceived their involvement in the consultation, using the Patient Participation Scale (PPS). The providers completed a self-administered questionnaire on their perception of patient’s involvement in the consultation. We compared scores of the PPS between MH+ and MH- facilities and between patients and providers. Results: The mean PPS score was 24.21 and 22.54 in MH+ and MH- health centres, respectively. Participation scores depended on both care providers and the health centres they work in. The patients consulting an MH+ centre were scoring higher on patient participation score than the ones of an MH- centre (adjusted odds ratio of 4.06 with a 95% CI of 1.17-14.10, p = 0.03). All care providers agreed they understood the patients' concerns, and patients shared this view. All patients agreed they wanted to be involved in the decision-making concerning their treatment; providers, however, were reluctant to do so. Conclusion: Integrating a mental health care package into versatile first-line health services can promote more patient-centred care . Key words: Mental health. Quality of care. Patient-centred care. Patient participation. Not-for-profit health centres. Guinea.
Systemic treatment of hormone receptor positive, human epidermal growth factor 2 negative metastatic breast cancer: retrospective analysis from Leeds Cancer Centre
Authors: Twelves Chris , Cheeseman Sue , Sopwith Will , Thompson Matthew , Riaz Majid , Ahat-Donker Necibe , Myland Melissa , Lee Adam , Przybysz Raymond , Turner Stuart , Hall Geoff , Perren Tim 
Published: November 2019

Abstract
BACKGROUND Study aimed to characterise treatment and outcomes for patients with hormone receptor positive (HR+), human epidermal growth factor 2 negative (HER2-) metastatic breast cancer (MBC) within a large regional cancer centre, as a benchmark for evaluating real-world impact of novel therapies such as CDK4/6 inhibitors.METHODS Retrospective longitudinal cohort, using electronic patient records of adult females with a first diagnosis of HR+/HER2- MBC January 2012 - March 2018.RESULTS 196 women were identified with HR+/HER2- MBC. Median age was 67 years, 85.2% were post-menopausal and median time between primary diagnosis and metastasis was 5.4 years. Most (75.1%) patients received endocrine therapy as first line systemic treatment (1st LoT); use of 1st LoT chemotherapy halved between 2012 and 2017. Patients receiving 1st LoT chemotherapy were younger and more likely to have visceral metastasis ( p <0.01). Median OS was 29.5 months and significantly greater for patients with exclusively non-visceral metastasis ( p <0.01). The adjusted hazard ratio for death of patients with visceral (or CNS) metastasis was 1.91 relative to those with exclusively non-visceral metastasis.CONCLUSIONS Diverse endocrine therapies predominate as 1st LoT for patients with HR+/HER2- MBC, chemotherapy being associated with more aggressive disease in younger patients, emphasising the importance of using effective and tolerable therapies early.
The impact of obstetric interventions and complications on women’s satisfaction with childbirth - a population based cohort study including 16000 women.
Authors: Falk Maja , Nelson Marie , Blomberg Marie 
Published: November 2019

Abstract
Background: As a quality marker and a tool for benchmarking between units, a visual analogue scale (VAS) (ranging from 1 to 10) to estimate woman’s satisfaction with childbirth was introduced in 2014. This study aimed to assess how obstetric interventions and complications affected women’s satisfaction with childbirth.

Methods: A retrospective cohort study including 16775 women with an available VAS score who gave birth between January 2016 and December 2017. VAS score, maternal and obstetric characteristics were obtained from electronic medical records and crude and adjusted odds ratios (aOR) were calculated.

Results: The total prevalence of dissatisfaction with childbirth (VAS 1-3) was 5.7%. The main risk factors for dissatisfaction with childbirth were emergency cesarean section, aOR 3.98 95% confidence interval (CI) 3.27-4.86, postpartum hemorrhage ³2000 ml, aOR 1.85 95%CI 1.24-2.76 and Apgar score <7 at five minutes, aOR 2.95 95%CI 1.95-4.47. The amount of postpartum hemorrhage showed a dose-response relation to dissatisfaction with childbirth. Moreover, labor induction, instrumental vaginal delivery, and obstetric anal sphincter injury were significantly associated with women´s dissatisfaction with childbirth. A total number of 4429/21204 (21%) women giving birth during the study period had missing values on VAS. A comparison of characteristics between women with and without a recorded VAS score was performed. There were statistically significant differences in maternal age and maternal BMI between the study population and excluded women due to missing values on VAS. Moreover, 64% of the women excluded were multiparas, compared to 59% in the study population.

Conclusions: Obstetric interventions and complications, including emergency cesareans section and postpartum hemorrhage, were significantly related to dissatisfaction with childbirth.

Such events are common and awareness of these associations might lead to a more individualized care of women during and after childbirth.
Intravenous recombinant tissue-type plasminogen activator thrombolysis for acute central retinal artery occlusion: a meta-analysis
Authors: Wang Xiaotang , Liu Yong , Suo Yan , Qin Dan , Meng Qiang , Zhang Yanchun , Zhang Hua , Wang Ying 
Published: November 2019

Abstract
Background: Central retinal artery occlusion (CRAO), an ocular stroke, causes severe and permanent visual impairment. Thrombolytic therapy is currently the main treatment option for CRAO. Intravenous thrombolysis with recombinant tissue-type plasminogen activator (rt-PA) has been extensively applied in the treatment of CRAO with the proven advantages of effectiveness and safety. This meta-analysis aimed to assess the efficacy of intravenous rt-PA thrombolysis for the management of CRAO by evaluating the pooled evidence. Methods: A comprehensive literature search of electronic databases including PubMed, OVID, and Cochrane Library was conducted up to and including March 2019. All studies reporting visual outcomes after CRAO (with thrombolytic therapy) were collected. Patient-level data on visual acuity (VA) and adverse events were recorded and assessed in this analysis. Data were inputted into the statistical software of STATA. The studies were weighted by the inverse of the variance and merged in a random-effects model. Results: The systematic review process yielded seven eligible studies including 121 patients with CRAO who received the intravenous rt-PA treatment. 62 patients showed improvement in VA (52.0%; 95% CI, 34.0%-70.0%) following rt-PA intravenous thrombolytic therapy. The observed improvement rate in the intravenous rt-PA treatment group was significantly higher than the conservative treatment group (40.4% vs. 13.0%; OR, =5.16; 95% CI, 1.90-14.05). The incidence rate of complications was relatively low (11 out of the 121 patients). Hemorrhage (9/11) was the major reported complication. Mortality was zero. Conclusion: This meta-analysis indicated that intravenous rt-PA thrombolysis could be an effective and safe strategy for the management of CRAO. However, a more detailed large-scale clinical trial is warranted to strengthen the evidence-based therapeutic guidance.