bluuebunny/crossref_metadata_2025_split huggingface dataset:
A nomogram model based on the preoperative clinical characteristics of papillary thyroid carcinoma with Hashimoto's thyroiditis to predict central lymph node metastasis
Authors: Zhao Wanjun , He Linye , Zhu Jingqiang , Su Anping 
Published: July 2020

AbstractObjectivePreoperative prediction of central lymph node (LN) metastasis in papillary thyroid carcinoma (PTC) with Hashimoto's thyroiditis (HT) provides an important basis for surgical decision‐making, especially regarding the extent of tumour resection. We aimed to develop and validate a nomogram model for the preoperative assessment of central LN metastasis.MethodsWe retrospectively collected the data of 994 PTC patients with HT who underwent surgery at the West China Hospital from January 2008 to December 2017. Among them, 606 patients who underwent surgeries relatively earlier comprised the training cohort for nomogram development, while the other 388 who underwent surgeries relatively later formed the validation cohort to validate the model's performance. Univariate and multivariate logistic regression analyses were conducted using the data of the two respective cohorts, as well as the data of the combined cohort. The relevant preoperative potential risk factors include demographic characteristics, medical history information, thyroid function test, ultrasound characteristics and BRAF V600E gene detection. A nomogram model was subsequently developed. The performance, discrimination and calibration of the nomogram model were assessed in the training and validation cohorts and in the combined cohort.ResultsThe central LN metastasis rate of PTC with HT was 49.7% (301/606) and 48.7% (193/388) in the training and validation cohorts, respectively. The univariate and multivariate logistic regression analyses indicated that younger age, normal body mass index, BRAF V600E mutation, larger maximum diameter, left lobe tumour, aspect ratio >1, capsular invasion and calcification were significant risk factors for central LN metastasis in PTC patients with HT. The preoperative nomogram showed good calibration and discrimination for the training and validation cohorts, as well as for the combined data set.ConclusionThe nomogram we developed and validated with a comprehensive set of preoperative factors is effective in predicting central LN metastasis in PTC patients with HT.
Utopia and Idiocy: Public Art Experiments in the Metropolitan Region of Barcelona
Authors: Sansi Roger 
Published: July 2020

AbstractThis article presents public art experiments that have taken place in cities of the metropolitan region of Barcelona, Spain. Some of these experiments were commissioned with the purpose of fostering social cohesion, but instead, they have made social dissent visible. I analyze these public art experiments through two terms that have been often used to question them: utopia and idiocy. I argue that both terms are important in understanding the politics of aesthetics in these experiments. My final objectives are first to assess if these experiments can help us better understand their urban and cultural context, and second if the politics of aesthetics is a good framework to analyze public art experiments.
Trends in the level of evidence and impact of clinical studies published in leading oral implantology journals: 2008–2018
Authors: Wu Xinyu , Hu Qing , Yan Qi , Zhang Tingting , Riley Philip , Hua Fang , Shi Bin , Tu Yu‐Kang 
Published: July 2020

AbstractObjectivesTo present the characteristics and level of evidence (LOE) of clinical studies published in leading oral implantology journals during 2008–2018 and to explore whether the LOE of a study is associated with its scientific and social impact.Materials and methodsClinical studies with direct relevance to the evaluation of healthcare interventions published in 2008, 2013, and 2018 in six oral implantology journals were identified via hand searches. A modified 4‐level Oxford 2011 LOE tool was used to assess the LOE of all eligible studies. The citation count and Altmetric Attention Score (AAS) of each study were extracted from Web of Science and Altmetric Explorer, respectively. Thereafter, multivariable generalized estimation equation analyses were used to investigate the association between LOE, citation counts, and AAS, adjusting for potential confounding factors and clustering effects.ResultsA total of 763 clinical studies were included, among which the proportion of level‐1, level‐2, level‐3, and level‐4 studies was 2.4%, 30.4%, 40.2%, and 27.0%, respectively. During 2008–2018, the proportion of high LOE studies (level‐1 and level‐2) increased substantially from 24.6% to 43.1%, although the number of systematic reviews that only include randomized controlled trials has remained limited. According to multivariable analyses, the citation count (p = .002) and AAS (p = .005) of high LOE studies were both significantly greater than those of low LOE studies.ConclusionsDuring the past decade, the proportion of high LOE studies has increased substantially in the field of oral implantology. Clinical studies with higher LOE tend to have greater scientific and social impact.
Navigating the mesentery: Part III. Unusual anatomy of ileocolic vessels
Authors: Stimec B. V. , Ignjatovic D. 
Published: July 2020

AbstractAimThe ileocolic vessels are important landmarks in advanced surgery of the midgut. The aim of the present study is to present variations of ileocolic vessels relevant to complete mesocolic excision with D3 lymphadenectomy of the right colon, within their detailed and precise morphometric framework and deriving from a large and consistent series of operated patients.MethodsAn ongoing prospective trial ‘Safe Radical D3 Right Hemicolectomy for Cancer through Preoperative Biphasic Multidetector Computed Tomography Angiography’ was reviewed. The imaging datasets underwent manual segmentation and 3D reconstruction, and the results were validated at surgery. A total of 356 patients were included in the study.ResultsA cross‐section of the series revealed five cases (1.4%) with variation of ileocolic vessels relevant to complete mesocolic excision or D3 extended mesenterectomy. There were two cases with absence of a true classical ileocolic artery, two cases with absence of a true classical ileocolic vein, and one case of precocious bifurcation of the ileocolic artery, left to the superior mesenteric vein. The entire D3 area in all the cases was thoroughly documented and analysed from the morphometric point of view (calibres, lengths of vessels, crossing patterns).ConclusionThe preoperative visualization of a patient’s individual 3D anatomy is a powerful tool in identifying the variations whose negligence could have dire consequences in complete mesocolic excision of the right colon.
The predictive value of the combined systolic‐diastolic index for atrial fibrillation after coronary artery bypass surgery
Authors: Camci Sencer , Ari Selma , Karakus Alper , Ari Hasan , Taner Temmuz 
Published: July 2020

AbstractObjectiveAtrial fibrillation (AF) after coronary artery bypass grafting (CABG) is a factor that causes an increase in mortality and morbidity. Therefore, predicting post‐CABG AF development is important for treatment management. In this study, we investigated the value of the ratio E/(Ea × Sa) as a combined systolic‐diastolic index in predicting post‐CABG AF development.MethodsThis prospective study included 102 patients who underwent only isolated coronary bypass. Preoperative demographic features, biochemical, and hematological parameters, and the electrocardiographic data of all patients were recorded. The E/(Ea × Sa) indices were calculated from the echocardiographic measurements. Those who retained their postoperative sinus rhythm were defined as group 1, and those who developed AF were defined as group 2.ResultsGroup 2 had significantly higher lateral (group 1:1.14 ± 0.61 vs. group 2:1.47 ± 0.87; P = .02), medial (group 1:1.61 ± 0.70 vs. group 2:1.99 ± 0.91; P = .02), and mean (group 1:1.30 ± 0.58 vs. group 2:1.62 ± 0.74; P = .001) E/(Ea × Sa) indices than group 1. In the univariate analysis, age, CHA2DS2‐VASc score, sPAP, IABP use, and mean E/(EaxSa) index were found to be significant predictors of post‐CABG AF development. However, only the mean E/(EaxSa) index was found to be a significant predictor of post‐CABG AF development in the multivariate analysis (OR: 2.19 95% CI 1.01–5.96; P = .045).ConclusionsThe combined systolic‐diastolic index predicted the development of post‐CABG AF.
Mutation profile and prognostic relevance in elderly patients with de novo acute myeloid leukemia treated with decitabine‐based chemotherapy
Authors: Ni Jing , Hong Jian , Long Zhangbiao , Li Qingsheng , Xia Ruixiang , Zeng Qingshu 
Published: July 2020

AbstractIntroductionDecitabine‐based chemotherapy regimens have shown efficacy in the treatment of elderly patients with acute myeloid leukemia (AML). However, it remains unclear whether any molecular alteration is correlated with the therapeutic effect of such treatment regimens.MethodsGene mutations were detected using next‐generation sequencing, and their impact on survival was investigated in elderly AML patients receiving decitabine‐based chemotherapy.ResultsA higher incidence of gene mutations was identified in elderly AML patients than in the younger cohorts. Elderly patients more frequently carried DNMT3A, IDH2, ASXL1, TET2, RUNX1, CEBPA single mutation (CEBPAsingle‐mut), and TP53 mutations. Survival analysis showed that DNMT3A, FLT3‐ITD, and TP53 mutations were associated with inferior overall survival (OS) and event‐free survival (EFS) in younger AML patients receiving standard treatment. However, in elderly patients treated with decitabine‐based chemotherapy, FLT3‐ITD, and ASXL1 mutations, but not DNMT3A and TP53 mutations, were associated with poor OS and EFS. Moreover, contrary to CEBPA double mutation (CEBPAdouble‐mut), CEBPAsingle‐mut was identified as an unfavorable prognostic factor.ConclusionThis study comprehensively analyzed the prognostic implications of gene mutations in elderly AML patients under decitabine‐based treatment modality. Identification of genetic biomarkers to predict the subgroup of elderly AML patients who can benefit from decitabine‐based regimens might have an immediate clinical utility to optimize the treatment of elderly AML patients.
Using pupillometry to investigate predictive processes in infancy
Authors: Zhang Felicia , Emberson Lauren L. 
Published: July 2020

AbstractPrediction, a prospective cognitive process, is increasingly believed to be crucial for adult cognition and learning. Despite decades of targeted research on prediction in adults, methodological limitations still exist for investigating prediction in infancy. In this article, we argue that pupillometry, or the measurement of pupil size, is an effective method to examine predictive processing in infants and will expand on existing methods (namely looking time and anticipatory eye movements). In particular, we argue that there are three specific features of pupillometry that make it particularly useful for augmenting the investigation of prediction in infancy. First, pupillometry has excellent temporal resolution that will facilitate the differentiation of prediction subcomponents. Second, pupillometry is highly continuous across the life span, allowing researchers to directly compare responses between infants and adults using an identical paradigm. Third, pupillometry can be used in conjunction with other behavioral measures, allowing for different yet complementary results. In addition, we review relevant adult and infant pupillometry studies that will facilitate infancy researchers to adopt this technique. Overall, pupillometry is particularly useful in investigating prediction in infancy and opens up several avenues for developmental research.
A Comparison of Two Tuberculins in Nonsensitized Macaques
Authors: Fox James G. , Niemi Steven M. , Murphy James C. 
Published: July 2020

Two tuberculins (mammalian and Old Tuberculin) were compared in three species of macaques after one of the tuberculins elicited nonspecific reactions up to 72 hours after intradermal inoculation in nontuberculous monkeys. A significant difference in initial intradermal eyelid reactivity between the tuberculins was found in some subjects. The heterogeneity of tuberculins and the necessity of accurate interpretation of intradermal testing are important components in addressing tuberculosis screening in nonhuman primate colonies.
Radiographic Evaluation of Appendicular Skeletal Maturation in the Common Marmoset (Callithrix jacchus)
Authors: Schultea T.D. , Smallwood J.E. , Stott G.G. 
Published: July 2020

The thoracic appendicular skeletal development of five common marmosets was monitored radiographically at weekly intervals from 1 day to 94 weeks of age and the times of appearance and fusion of 47 ossification centers were recorded. A range and average age for the appearance and fusion of each ossification center were calculated and compared to data available for the rhesus monkey and man.
Response of Monkeys to Porcine Zona Pellucida as Detected by a Solid‐Phase Radioimmunoassay
Authors: Gulyas Bela J. , Yuan Lydia C. , Gwatkin R.B.L. , Schmell Eli D. 
Published: July 2020

The immunological response of cynomolgus monkeys {Macaca fascicularis) to immunization was evaluated utilizing collagcnase‐isolated pig zona pellucida. Six weeks after initial immunization a high serum titer of antibody was exhibited. Serum antibody titers demonstrated a noticeable decline 5 months after booster injections were discontinued. The assay method used is rapid and is capable of detecting antibody in serum dilutions of 1:78,000, as compared to 1:125,000 with the indirect fluorescence assay.
Psychometric properties of the Emotional Quotient Inventory: Youth Version‐EQ‐i:YV in Spanish adolescents with Down syndrome
Authors: Robles‐Bello María Auxiliadora , Sánchez‐Teruel David , Galeote Moreno Miguel Ángel 
Published: July 2020

AbstractBackgroundThe people with Down syndrome who are now adolescents can face a self‐report questionnaire with guarantees of being answered with validity to evaluate areas of development that traditionally have not been able to be evaluated. This is the case of emotional intelligence, measured in this research with the Emotional Quotient Inventory: Youth Version‐EQ‐i:YV.AimsTo validate and analyse the scale's psychometric properties in adolescents with Down syndrome.MethodsA two‐stage cross‐sectional investigation was conducted. The inventory consists of 60 items that measure 5 dimensions. The test was administered to 644 adolescents with Down syndrome. We carried out exploratory and confirmatory factor analyses.OutcomesThe 5‐factor structure of the test was confirmed. The internal consistency of four dimensions and the EQ‐i:YV’s total calculated score yielded high values.ConclusionsThis new version of the EQ‐i:YV represents a valid and reliable tool to assess emotional intelligence in Spanish adolescents with Down syndrome.
Practical recommendations for systemic treatment in psoriasis according to age, pregnancy, metabolic syndrome, mental health, psoriasis subtype and treatment history (BETA‐PSO: Belgian Evidence‐based Treatment Advice in Psoriasis; part 1)
Authors: Lambert J.L.W. , Segaert S. , Ghislain P.D. , Hillary T. , Nikkels A. , Willaert F. , Lambert J. , Speeckaert R. 
Published: July 2020

AbstractBackgroundImpressive progress in new therapeutic options has been made for psoriasis. Treatments include topical steroids, phototherapy, conventional, synthetic disease‐modifying drugs and an expanding list of biologics.ObjectiveThe primary objective of this work was to collect evidence for the creation of practice guidelines for systemic treatment of psoriasis (BETA‐PSO: Belgian Evidence‐based Treatment Advice in Psoriasis).MethodsEvidence‐based recommendations were formulated using a quasi‐Delphi methodology after a systematic search of the literature and a consensus procedure involving 8 psoriasis experts.ResultsIn this part, the use of systemic treatment in different age groups, during pregnancy, in metabolic syndrome, in patients with mental health problems, in different psoriasis subtypes and in previously systemically treated patients treatment is discussed.ConclusionGuidance on therapeutic choice in specific clinical situations in psoriasis is provided in order to facilitate the decision‐making in clinical practice.
The role of light in regulating seed dormancy and germination
Authors: Yang Liwen , Liu Shuangrong , Lin Rongcheng 
Published: July 2020

AbstractSeed dormancy is an adaptive trait in plants. Breaking seed dormancy determines the timing of germination and is, thereby essential for ensuring plant survival and agricultural production. Seed dormancy and the subsequent germination are controlled by both internal cues (mainly hormones) and environmental signals. In the past few years, the roles of plant hormones in regulating seed dormancy and germination have been uncovered. However, we are only beginning to understand how light signaling pathways modulate seed dormancy and interaction with endogenous hormones. In this review, we summarize current views of the molecular mechanisms by which light controls the induction, maintenance and release of seed dormancy, as well as seed germination, by regulating hormone metabolism and signaling pathways.
Profiling of circular RNA N6‐methyladenosine in moso bamboo (Phyllostachys edulis) using nanopore‐based direct RNA sequencing
Authors: Wang Yongsheng , Wang Huihui , Xi Feihu , Wang Huiyuan , Han Ximei , Wei Wentao , Zhang Hangxiao , Zhang Qianyue , Zheng Yushan , Zhu Qiang , Kohnen Markus V. , Reddy Anireddy S. N. , Gu Lianfeng 
Published: July 2020

AbstractN6‐methyladenosine (m6A) is a prevalent modification in messenger RNAs and circular RNAs that play important roles in regulating various aspects of RNA metabolism. However, the occurrence of the m6A modification in plant circular RNAs has not been reported. A widely used method to identify m6A modifications relies on m6A‐specific antibodies followed by next‐generation sequencing of precipitated RNAs (MeRIP‐Seq). However, one limitation of MeRIP‐Seq is that it does not provide the precise location of m6A at single‐nucleotide resolution. Although more recent sequencing techniques such as Nanopore‐based direct RNA sequencing (DRS) can overcome such limitations, the technology does not allow sequencing of circular RNAs, as these molecules lack a poly(A) tail. Here, we developed a novel method to detect the precise location of m6A modifications in circular RNAs using Nanopore DRS. We first enriched our samples for circular RNAs, which we then fragmented and sequenced on the Nanopore platform with a customized protocol. Using this method, we identified 470 unique circular RNAs from DRS reads based on the back‐spliced junction region. Among exonic circular RNAs, about 10% contained m6A sites, which mainly occurred around acceptor and donor splice sites. This study demonstrates the utility of our antibody‐independent method in identifying total and methylated circular RNAs using Nanopore DRS. This method has the additional advantage of providing the exact location of m6A sites at single‐base resolution in circular RNAs or linear transcripts from non‐coding RNA without poly(A) tails.
Psychosocial Bullying Among Nurse Educators: Exploring Coping Strategies and Intent to Leave
Authors: Wunnenberg Mary 
Published: July 2020

AbstractPurposeTo examine the incidence of workplace bullying among nurse educators and explore potential relationships between workplace bullying, professional demographics, coping strategies, and intent to leave.DesignThe investigator used a cross‐sectional, descriptive, correlational design and Bronfenbrenner’s Process‐Person‐Context‐Time model to examine workplace bullying among nurse educators in the northeastern United States.MethodsA web‐based survey was utilized to collect data from a final sample of 470 nurse educators from nine states in the northeastern United States. The instruments included a demographic section, followed by the Negative Acts Questionnaire‐Revised (NAQ‐R), the Coping Strategy Indicator (CSI), and a three‐item job intent turnover questionnaire. Descriptive and parametric statistics were generated for data analysis.FindingsForty‐five percent (n = 212) of participants self‐identified as targets of bullying in the workplace within the preceding 6 months. The most frequently reported negative acts encountered among the nurse educators surveyed were being excluded, having one’s opinion ignored, and being exposed to an unmanageable workload. Furthermore, statistically significant relationships were identified between workplace bullying and coping strategies (r = .53: p < .01) and intent to leave (r = .58: p < .01) among nurse educators.ConclusionsWorkplace bullying among nurse educators is a serious problem impacting the profession. Heightened awareness and diverse initiatives targeting workplace bullying can positively impact retention of qualified nurse educators.Clinical RelevanceFindings from this study may contribute to the development of strategies to mitigate the effects of psychosocial bullying and enhance retention of nurse educators.
Anatomy and ontogenetic changes of the facial and gular musculature of the tetra Astyanax brucutu: A remarkable case of adaptation to durophagy
Authors: Vita George , Zanata Angela Maria , Datovo Aléssio 
Published: July 2020

AbstractAstyanax brucutu is a peculiar species of Neotropical tetra endemic from the Chapada Diamantina, a large plateau in northeastern Brazil. Individuals of this species undergo a dramatic ontogenetic shift in their diet that is accompanied by equally remarkable changes in their feeding apparatus. Whereas juveniles of A. brucutu feed mostly on algae, adults feed almost exclusively on an endemic species of hydrobiid snail and other associated living organisms that inhabit their dead shells (including infaunal invertebrates and algae). Skeletal adaptations associated with this change in diet were previously reported, but until now, the changes in the musculature remained mostly unknown. The present paper describes the facial and gular muscles, as well as the buccal ligaments of A. brucutu in different life stages, and identifies the major ontogenetic changes in these systems associated with the diet shift in the species. Such changes primarily involve expansions of specific portions of the adductor mandibulae and associated tendons and ligaments that likely represent adaptations to increase the biting power necessary to crush copious amounts of shells ingested by larger individuals of A. brucutu. Those adaptations are absent in specimens of any size of Astyanax cf. fasciatus, a sympatric congener lacking durophagous feeding habits. Anatomical comparisons and landmark‐based principal components analysis (PCA) suggest that most specializations to durophagy in A. brucutu arose by peramorphosis. We also found that several of the muscular specializations of adults of A. brucutu are paralleled in species of Creagrutus and Piabina, two other characid genera distantly related to Astyanax, but that also feed on hard food items.