bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of waveform-derived corneal stiffness and stress-strain extensometry-derived corneal stiffness using different cross-linking irradiances: an experimental study with air-puff applanation of ex vivo porcine eyes
Authors: Herber Robert , Francis Mathew , Spoerl Eberhard , Pillunat Lutz E. , Raiskup Frederik , Sinha Roy Abhijit 
Published: June 2020

Abstract
Purpose
To assess corneal stiffening of standard (S-CXL) and accelerated (A-CXL) cross-linking protocols by dynamic corneal response parameters and corneal bending stiffness (Kc[mean/linear]) derived from Corvis (CVS) Scheimpflug-based tonometry. These investigations were validated by corneal tensile stiffness (K[ts]), derived from stress-strain extensometry in ex vivo porcine eyes.

Methods
Seventy-two fresh-enucleated and de-epithelized porcine eyes were soaked in 0.1% riboflavin solution including 10% dextran for 10 min. The eyes were separated into four groups: controls (n = 18), S-CXL (intensity in mW/cm2*time in min; 3*30) (n = 18), A-CXL (9*10) (n = 18), and A-CXL (18*5) (n = 18), respectively. CXL was performed using CCL Vario. CVS measurements were performed on all eyes. Subsequently, corneal strips were extracted by a double-bladed scalpel and used for stress-strain measurements. K[ts] was calculated from a force-displacement curve. Mean corneal stiffness (Kc[mean]) and constant corneal stiffness (Kc[linear]) were calculated from raw CVS data.

Results
In CVS, biomechanical effects of cross-linking were shown to have a significantly decreased deflection amplitude as well as integrated radius, an increased IOP, and SP A1 (P < 0.05). Kc[mean]/Kc[linear] were significantly increased after CXL (P < 0.05). In the range from 2 to 6% strain, K[ts] was significantly higher in S-CXL (3*30) compared to A-CXL (9*10), A-CXL (18*5), and controls (P < 0.05). At 8% to 10% strain, all protocols induced a higher stiffness than controls (P < 0.05).

Conclusion
Several CVS parameters and Kc[mean] as well as Kc[linear] verify corneal stiffening effect after CXL on porcine eyes. S-CXL seems to have a higher tendency of stiffening than A-CXL protocols have, which was demonstrated by Scheimpflug-based tonometry and stress-strain extensometry.
p16 in highly malignant esophageal carcinomas: the correlation with clinicopathological factors and human papillomavirus infection
Authors: Ishida Hirotaka , Kasajima Atsuko , Fujishima Fumiyoshi , Akaishi Ryujiro , Ueki Shunsuke , Yamazaki Yuto , Onodera Yoshiaki , Gao Xin , Okamoto Hiroshi , Taniyama Yusuke , Kamei Takashi , Sasano Hironobu 
Published: June 2020

Abstractp16 is generally considered to be a surrogate maker of human papillomavirus (HPV) infection and also a predictive marker of favorable clinical outcome of patients with squamous cell carcinoma of the oropharynx. p16 overexpression is also known to be induced by deregulation ofRB1in neuroendocrine carcinomas. In highly malignant esophageal neoplasms, however, the status of p16 has remained largely unknown. We immunolocalized p16 and Rb1 in 82 surgically resected esophageal high-grade squamous cell carcinomas (46 poorly differentiated and 36 basaloid squamous cell carcinomas) and 15 esophageal small-cell carcinomas in order to clarify the clinical and biological significance of p16. p16 immunoreactivity was detected in 7/82 (9%) high-grade squamous cell carcinomas and 15 (100%) small-cell carcinomas. p16 immunoreactivity was significantly associated with Rb1 protein loss in both groups (P < 0.001). HPV was detected in none of the p16-positive cases examined. Clinical outcome of the p16-positive high-grade squamous cell carcinomas was not different from that of the p16-negative counterparts (P = 0.687) but significantly better than those with the small-cell carcinomas (P = 0.023). p16 was therefore considered to be induced through an inactivation of the RB1 signaling pathway and not through HPV infection in highly malignant esophageal neoplasms. Nevertheless, patients’ clinical outcome of these neoplasms significantly differs; therefore, small-cell carcinomas have to be carefully differentiated from other neoplasms. In addition, p16 overexpression is not predictive of favorable clinical outcome in high-grade squamous cell carcinomas of the esophagus.
Paediatric femur fractures—the value of contextual information on judgement in possible child abuse cases: are we bias?
Authors: Loos Marie-Louise H. J. , Allema Wies M. , Bakx Roel , Stoel Reinoud D. , van Rijn Rick R. , Karst Wouter A. 
Published: June 2020

AbstractThe majority of paediatric femur fractures result from accidental trauma; however, it is important to consider non-accidental trauma, especially in pre-ambulatory children. We study whether irrelevant contextual information subconsciously influences conclusions of healthcare professionals with respect to whether observations provide evidence for non-accidental trauma. A survey with nine radiographs of femur shaft fractures was designed. Two different clinical histories (vignettes) with contextual information were designed, non-abuse versus abuse context. One of both vignettes was randomly assigned to the radiograph shown to the participant, followed by a question with a 5-point answer scale, which represents a verbal expression of the likelihood ratio of the fracture regarding a non-accidental versus accidental cause. Participants were medical residents and staff members of different specialties from several Dutch hospitals. A total of 172 participants responded. The reported evidential strength of the vignettes with a non-abuse context was 0.19 (n = 784; 95%CI 0.10–0.28) and for the abuse context 0.94 (n = 764; 95%CI 0.86–1.02; p < 0.001). Women reported a stronger evidential strength than men, but both were influenced by context. Emergency department and paediatric doctors were more likely to decide that non-accidental trauma was the cause; paediatric radiologists were the least likely. Experience in years of practice and current function did not prevent participants from being bias.Conclusion: This study shows that the interpretation of medical results by healthcare professionals can be influenced by contextual information, such as low income and marital status, which are irrelevant to the decision as to whether abuse might have occurred. Given the same information about an injury, women, emergency department and paediatric doctors were more likely to decide that non-accidental trauma was the cause, while paediatric radiologists were least likely to decide this outcome. It is important to prevent contextual influence as much as possible, by recognizing it and implementing a management contextual information procedure.

What is Known:• Contextual information is of possible influence on healthcare professionals in identifying non-accidental trauma.• Increased working experience is thought to be protective against this influence.

What is New:• Contextual information influenced the interpretation of medical results by healthcare professionals regardless of work experience.• The interpretation of medical results by healthcare professionals is influenced by both affirmative and negative contextual information.
Glial cell line-derived neurotrophic factors (GFLs) and small molecules targeting RET receptor for the treatment of pain and Parkinson’s disease
Authors: Mahato Arun Kumar , Sidorova Yulia A. 
Published: June 2020

AbstractRearranged during transfection (RET), in complex with glial cell line-derived (GDNF) family receptor alpha (GFRα), is the canonical signaling receptor for GDNF family ligands (GFLs) expressed in both central and peripheral parts of the nervous system and also in non-neuronal tissues. RET-dependent signaling elicited by GFLs has an important role in the development, maintenance and survival of dopamine and sensory neurons. Both Parkinson’s disease and neuropathic pain are devastating disorders without an available cure, and at the moment are only treated symptomatically. GFLs have been studied extensively in animal models of Parkinson’s disease and neuropathic pain with remarkable outcomes. However, clinical trials with recombinant or viral vector-encoded GFL proteins have produced inconclusive results. GFL proteins are not drug-like; they have poor pharmacokinetic properties and activate multiple receptors. Targeting RET and/or GFRα with small molecules may resolve the problems associated with using GFLs as drugs and can result in the development of therapeutics for disease-modifying treatments against Parkinson’s disease and neuropathic pain.
An improved bat optimization algorithm to solve the tasks scheduling problem in open shop
Authors: Shareh Morteza Babazadeh , Bargh Shirin Hatami , Hosseinabadi Ali Asghar Rahmani , Slowik Adam 
Published: June 2020

AbstractThe open shop scheduling problem involves a set of activities that should be run on a limited set of machines. The purpose of scheduling open shops problem is to provide a timetable for implementation of the entire operation so that the total execution time is reduced. The tasks scheduling problem in open shops is important in many applications due to the arbitrariness of the processing sequence of each job and lack of a prioritization of its operations. This is an NP-hard problem and obtaining an optimal solution to this problem requires a high time complexity. Therefore, heuristic techniques are used to solve these problems. In this paper, we investigate the tasks scheduling problem in open shops using the Bat Algorithm (BA) based on ColReuse and substitution meta-heuristic functions. The heuristic functions are designed to increase the rate of convergence to the optimal solution. To evaluate the performance of the proposed algorithm, standard open shop benchmarks were used. The results obtained in each benchmark are compared with those of the previous methods. Finally, after analyzing the results, it was found that the proposed BA had a better performance and was able to generate the best solution in all cases.
Applying artificial neural networks for modelling ship speed and fuel consumption
Authors: Tarelko Wieslaw , Rudzki Krzysztof 
Published: June 2020

AbstractThis paper deals with modelling ship speed and fuel consumption using artificial neural network (ANN) techniques. These tools allowed us to develop ANN models that can be used for predicting both the fuel consumption and the travel time to the destination for commanded outputs (the ship driveline shaft speed and the propeller pitch) selected by the ship operator. In these cases, due to variable environmental conditions, making decisions regarding setting the proper commanded outputs to is extraordinarily difficult. To support such decisions, we have developed a decision support system. Its main elements are the ANN models enabling ship fuel consumption and speed prediction. To collect data needed for building ANN models, sea trials were conducted. In this paper, the decision support system concept, input and variables of the ship driveline system models, and data acquisition methods are presented. Based on them, we developed appropriate ANN models. Subsequently, we performed a quality assessment of the collected data set, data normalization and division of the data set, selection of an ANN model architecture and assessment of their quality.
Multiplicity and concentration of solutions to the nonlinear magnetic Schrödinger equation
Authors: Ji Chao , Rădulescu Vicenţiu D. 
Published: June 2020

AbstractIn this paper, we study the following nonlinear magnetic Schrödinger equation$$\begin{aligned} \left\{ \begin{aligned}&\Big (\frac{\varepsilon }{i}\nabla -A(x)\Big )^{2}u+V(x)u=f(|u|^{2})u \quad \hbox {in }{\mathbb {R}}^N\ (N\ge 2),\\&u\in H^{1}({\mathbb {R}}^{N}, {\mathbb {C}}), \end{aligned} \right. \end{aligned}$$(εi∇-A(x))2u+V(x)u=f(|u|2)uinRN(N≥2),u∈H1(RN,C),where$$\epsilon $$ϵis a positive parameter, and$$V:{\mathbb {R}}^{N}\rightarrow {\mathbb {R}}$$V:RN→R,$$A: {\mathbb {R}}^{N}\rightarrow {\mathbb {R}}^{N}$$A:RN→RNare continuous potentials. Under a local assumption on the potentialV, by combining variational methods, penalization techniques, and the Ljusternik–Schnirelmann theory, we prove multiplicity and concentration properties of solutions for$$\varepsilon >0$$ε>0small. In our problem, the functionfis only continuous, which allows to consider larger classes of nonlinearities in the reaction.
Incidence and predictors of kyphotic deformity following resection of cervical intradural tumors in adults: a population-based cohort study
Authors: Tatter Charles , Fletcher-Sandersjöö Alexander , Persson Oscar , Burström Gustav , Grane Per , Edström Erik , Elmi-Terander Adrian 
Published: June 2020

AbstractBackgroundThe first line of treatment for most cervical intradural tumors is surgical resection through laminotomy or laminectomy. This may cause a loss of posterior pulling force leading to kyphosis, which is associated with decreased functional outcome. However, the incidence and predictors of kyphosis in these patients are poorly understood.ObjectTo assess the incidence of posterior fixation (PF), as well as predictors of radiological kyphosis, following resection of cervical intradural tumors in adults.MethodsA population-based cohort study was conducted on adult patients who underwent intradural tumor resection via cervical laminectomy with or without laminoplasty between 2005 and 2017. Primary outcome was kyphosis requiring PF. Secondary outcome was radiological kyphotic increase, measured by the change in the C2–C7 Cobb angle between pre- and postoperative magnetic resonance images.ResultsEighty-four patients were included. Twenty-four percent of the tumors were intramedullary, and the most common diagnosis was meningioma. The mean laminectomy range was 2.4 levels, and laminoplasty was performed in 40% of cases. No prophylactic PF was performed. During a mean follow-up of 4.4 years, two patients (2.4%) required delayed PF. The mean radiological kyphotic increase after surgery was 3.0°, which was significantly associated with laminectomy of C2 and C3. Of these, C3 laminectomy demonstrated independent risk association.ConclusionsThere was a low incidence of delayed PF following cervical intradural tumor resection, supporting the practice of not performing prophylactic PF. Kyphotic increase was associated with C2 and C3 laminectomy, which could help identify at-risk patients were targeted follow-up is indicated.
A wind-driven model of the ocean surface layer with wave radiation physics
Authors: Olbers Dirk , Jurgenowski Philipp , Eden Carsten 
Published: June 2020

AbstractSurface windstress transfers energy to the surface mixed layer of the ocean, and this energy partly radiates as internal gravity waves with near-inertial frequencies into the stratified ocean below the mixed layer where it is available for mixing. Numerical and analytical models provide estimates of the energy transfer into the mixed layer and the fraction radiated into the interior, but with large uncertainties, which we aim to reduce in the present study. An analytical slab model of the mixed layer used before in several studies is extended by consistent physics of wave radiation into the interior. Rayleigh damping, controlling the physics of the original slab model, is absent in the extended model and the wave-induced pressure gradient is resolved. The extended model predicts the energy transfer rates, both in physical and wavenumber-frequency space, associated with the wind forcing, dissipation in the mixed layer, and wave radiation at the base as function of a few parameters: mixed layer depth, Coriolis frequency and Brunt-Väisälä frequency below the mixed layer, and parameters of the applied windstress spectrum. The results of the model are satisfactorily validated with a realistic numerical model of the North Atlantic Ocean.
Toxicity of essential oils to slug parasitic and entomopathogenic nematodes
Authors: Barua Archita , McDonald-Howard Kerry-Lyn , Mc Donnell Rory J. , Rae Robbie , Williams Christopher D. 
Published: June 2020

AbstractEssential oils are being increasingly utilised as a biorational element in integrated pest management regimes. Whereas there has been much research on the effects of these oils on mortality and behaviour of pestiferous molluscs, insects and nematodes, there has (to the present authors’ knowledge) been no research into their effects on the mortality and behaviour of beneficial nematodes. We address this lacuna by conducting laboratory assays on the behaviour (thrashing assays) and mortality of 13 essential oils plus controls of Tween and water on the malacophagous nematode Phasmarhabditis hermaphrodita and two species of entomopathogenic nematodes, namely: Steinernema feltiae and Heterorhabditis bacteriophora. Mortality results showed an “all or nothing” response with only three oils—pine oil, peppermint and lemongrass—displaying intermediate mortalities. Also, toxicity of essential oils was conserved across phylogenetically quite distinct beneficial nematode species with oil toxicity largely being repeated across the three beneficial nematodes. Thrashing assays confirmed the toxic effects of certain oils. We recommend that the effects of essential oils be tested on beneficial organisms in ecosystems before choices are made over which oils should be used. The present paper highlights some oils which are not toxic to beneficial nematodes but may affect their behaviour. Research should focus on these oils as part of a biorational control programme for pestiferous molluscs and insects.
Scalar Gradient and Strain Rate Statistics in Oblique Premixed Flame–Wall Interaction Within Turbulent Channel Flows
Authors: Ahmed Umair , Chakraborty Nilanjan , Klein Markus 
Published: June 2020

AbstractThree-dimensional direct numerical simulations of V-flames interacting with chemically inert walls in a fully developed turbulent channel flow have been performed under adiabatic and isothermal wall boundary conditions using single-step chemistry. These simulations are representative of stoichiometric methane-air mixture at unity Lewis number under atmospheric conditions. The turbulence in the non-reacting channel is representative of the friction velocity based Reynolds number$$Re_{\tau }=110$$Reτ=110. Differences in the statistical behaviours of the mean values of progress variable, temperature, and density have been reported for different wall boundary conditions. It is found that the mean location of the oblique flame interacting with the wall is affected by the choice of the wall boundary condition used. The influence of these differences on the flame dynamics is investigated by analysing the statistical behaviours of the surface density function (SDF) and the strain rates, which govern the evolution of the SDF. The mean variation of the SDF and the flame displacement speed are strongly affected by the wall boundary condition within the viscous sub-layer region of the boundary layer. The behaviours of the normal and tangential strain rates are found to be influenced by not only the differences in the wall boundary conditions, but also by the distance from the wall. The differences in the displacement speed statistics for different wall boundary conditions and wall distance affect the behaviours of the normal strain rate arising due to flame propagation and curvature stretch. The changes in the SDF behaviour in the near wall region have been explained in terms of the statistics of effective normal strain rate experienced by the progress variable iso-surfaces under different wall boundary conditions and wall normal distances.
Moral Challenges When Suspecting Abuse and Neglect in School Children: A Mixed Method Study
Authors: Forsner M. , Elvhage G. , Ewalds-Kvist B. M. , Lützén K. 
Published: June 2020

AbstractThe World Health Organization (WHO), concludes that child maltreatment is a global concern calling for a multi sectoral interdisciplinary approach. School professionals, such as social workers, teachers, and health care professionals are in positions to discover and report maltreatment enabling social workers to intervene. However, a variety of reports reveal an evident gap between incidences and frequency of number of cases reported. A review of relevant research indicates that the problem of “not reporting” suggests that moral conflicts are activated in the process of decision-making. The aim was to gain a deeper understanding of school professionals’ experiences of reporting suspected neglect and abuse to the Social Welfare Board. In a mixed method approach 32 school professionals, such as teachers, social workers, nurses and psychologists participated in interviews and responded to questionnaires. Findings from the qualitative content analysis were compared to the quantitative analysis in a meta-analysis. Moral conflicts occur when faced with making decisions about how to best deal with a child’s situation. Thoughts about the child’s best interest and relationship with his/her parents as well as the informants´ own safety, were central. The comparative meta- analysis of both data sets revealed these conflicts commence with a moral sensitivity of possible negative consequences for the child. Moral sensitivity can be viewed as a “good” personal attribute, it paradoxically might lead to moral stress despite an open ethical climate. Based on the results of this study, further research on the interpersonal aspects of dealing with moral conflicts involved in reporting suspected child abuse is indicated.
Comparison of novelty detection methods for multispectral images in rover-based planetary exploration missions
Authors: Kerner Hannah R. , Wagstaff Kiri L. , Bue Brian D. , Wellington Danika F. , Jacob Samantha , Horton Paul , Bell James F. , Kwan Chiman , Ben Amor Heni 
Published: June 2020

AbstractScience teams for rover-based planetary exploration missions like the Mars Science Laboratory Curiosity rover have limited time for analyzing new data before making decisions about follow-up observations. There is a need for systems that can rapidly and intelligently extract information from planetary instrument datasets and focus attention on the most promising or novel observations. Several novelty detection methods have been explored in prior work for three-channel color images and non-image datasets, but few have considered multispectral or hyperspectral image datasets for the purpose of scientific discovery. We compared the performance of four novelty detection methods—Reed Xiaoli (RX) detectors, principal component analysis (PCA), autoencoders, and generative adversarial networks (GANs)—and the ability of each method to provide explanatory visualizations to help scientists understand and trust predictions made by the system. We show that pixel-wise RX and autoencoders trained with structural similarity (SSIM) loss can detect morphological novelties that are not detected by PCA, GANs, and mean squared error autoencoders, but that the latter methods are better suited for detecting spectral novelties—i.e., the best method for a given setting depends on the type of novelties that are sought. Additionally, we find that autoencoders provide the most useful explanatory visualizations for enabling users to understand and trust model detections, and that existing GAN approaches to novelty detection may be limited in this respect.