bluuebunny/crossref_metadata_2025_split huggingface dataset:
Internal Motor Tempo Contributes to the Determination of Preferred Music Tempo Regardless of Music Familiarity.
Authors: Hine Kyoko , Abe Koki , Kinzuka Yuya , Shehata Mohammad , Hatano Katsunobu , Matsui Toshie , Nakauchi Shigeki 
Published: November 2020

Abstract
Humans have long listened to music. However, it is still unclear why people prefer some types of music over others. To investigate how music preference is determined, previous studies have focused on preferred music tempo since tempo can essentially determine music preference. Such studies have reported that external music components as well as internal motor tempo determine tempo preference. Moreover, it has been suggested that familiarity with a piece of music affects the impact of external music components on tempo preference. However, the question of how the contributions of the internal motor tempo and external music components for tempo preference simultaneously change depending on familiarity has not been investigated. Moreover, the issue of which external music components contribute to tempo preference depending on familiarity has not been clarified. Here, we investigate how the preference for music tempo is determined by the internal motor tempo and external music components depending on familiarity with a piece of music. Twenty-three participants adjusted music tempos according to their preferences and rated their music familiarity. In addition, they engaged in finger tapping at their preferred tempo. Music components, such as typically performed tempo or the number of notes, were also analysed. Analysis of the collected data with multiple linear regressions showed that the preferred tapping tempo contributed to the preferred music tempo regardless of familiarity, whereas the contributions of some of the music components changed depending on familiarity. The typically performed tempo that might relate to the memory of a piece of music contributed to the estimation of the preferred music tempo for familiar music, and the number of notes or the pitch that might relate to perceived tempo contributed to the estimation of unfamiliar music. These results suggested that internal motor tempo is constantly involved in tempo preference regardless of music familiarity, whereas the contribution of external music components varies depending on whether a piece of music has been memorized.
Cost-Effectiveness Analysis of Atrial Fibrillation Screening for Stroke Prevention in China: A Markov Model
Authors: Zhou Lihui , Cao Ye , Gao Bei , Lu Wenli , Wang Yuan 
Published: November 2020

Abstract
Objectives: To evaluate the cost-effectiveness of community-based Atrial fibrillation (AF) screening by 12-lead electrocardiogram (ECG) in Chinese healthcare setting.Methods: A Markov state transition model was used to simulate the costs and effects on a 55/65/75-year-old cohort under routine care and AF screening by 12-lead ECG. The circle length was 1 year, and people were simulated until 90 years old. The cost-effectiveness analysis was perform using a societal perspective. Transition probability, costs, and utility data were derived from open dataset and published literature. One-way and probabilistic sensitivity analyses were performed to exam the uncertainty of the results. Results: Annual AF screening in 65/75-year-old cohort was highly cost-effective with the incremental cost-effectiveness ratio (ICER) Chinese Yuan Renminbi (CNY) 64147/49736 per quality-adjusted life year (QALY) gained. Annual AF screening in 65/75-year-old cohort was associated with 535/492 prevented ischemic strokes and 174/163 more intracerebral hemorrhages, and the anticoagulation rate increased from the assumed 10% on routine care to 61.5%. Probabilistic sensitivity analysis indicated that these two strategies have 55% and 78% chances of being cost-effective at a willingness-to-pay (WTP) threshold of 1× gross domestic product per capita of China in 2019, US $10635 QALY.Conclusion: Annual community-based screening of population aged 65 years and older in China is likely to be cost-effective at conventional willingness-to-pay thresholds to reduce the unnecessary burden of strokes.
A Highly Sensitive and Wide-Range Resonant Magnetic Micro-Sensor Based on A Buckled Micro-Beam
Authors: ALCHEIKH Nouha , Mbarek Sofiane , Younis Mohammad 
Published: November 2020

Abstract
We experimentally demonstrate a miniature highly sensitive wide-range resonant magnetic Lorentz-force micro-sensor. The concept is demonstrated based on the detection of the resonance frequency of an in-plane electrothermally heated straight resonator operated near the buckling point. The frequency shift is measured with optical sensing and the device is operating at atmospheric pressure. The magnetometer demonstrates a sensitivity (S) of 33.9/T, which is very high compared to the state of the art. In addition, the micro-sensor shows a good linearity in wide range and low power consumption around 0.2 mW. The above performances make the proposed micro-sensor promising for various low-cost magnetic applications.
Crucial Role of the YAP/TEAD Axis in Osteosarcoma Tumor Growth: Effects of YAP Inhibitors Verteporfin and CA3 on Tumor Growth in vivo
Authors: Morice Sarah , Mullard Mathilde , Brion Regis , Dupuy Maryne , Renault Sarah , Tesfaye Robel , Ory Benjamin , Redini Francoise , Verrecchia Franck 
Published: November 2020

Abstract
BackgroundOsteosarcoma is the first primary bone tumor in children and adolescents. Despite progress in the understanding of the biology of these tumors, survival rates have progressed very little in recent decades. In this context, although some studies suggested that disruption of the Hippo signaling pathway is associated with osteosarcoma progression, the molecular mechanisms by which YAP regulates primary tumor growth is not fully clarified. In addition, the validation of YAP as a therapeutic target through the use of inhibitors in a preclinical model must be demonstrated.MethodsThe identification of a YAP signature was carried out by RNAseq analysis from a cohort of patients. Survival rates were assessed by Kaplan-Meier assays. The role of TEAD in the control of osteosarcoma cell proliferation by YAP has been realized by various molecular and cellular biology approaches (RNAseq, PLA, immunoprecipitation, promoter/specific gene, proliferation, cell cycle assays) using overexpression of mutated forms of YAP able or unable to interact with TEAD. The role of TEAD in YAP regulation of primary tumor growth, and the effects of YAP inhibitors in vivo were realized using an orthotopic model of osteosarcoma. ResultsRNA-seq analysis and Kaplan-Meier assays identified a YAP signature in osteosarcoma patients and a correlation with patients outcome. Molecular and cellular analysis using overexpression of mutated forms of YAP able or unable to interact with TEAD, indicate that TEAD is crucial for YAP-driven cell proliferation and in vivo tumor growth. In addition, in vivo experiments show that two YAP/TEAD inhibitors, verteporfin and CA3, reduce primary tumor growth. In this context, in vitro experiments demonstrate that these inhibitors decrease YAP expression, YAP/TEAD transcriptional activity and cell viability mainly by their ability to induce cell apoptosis.ConclusionWe thus demonstrate that the YAP/TEAD signaling axis is a central actor in mediating primary tumor growth of osteosarcoma, and that the use of YAP inhibitors may be a promising therapeutic strategy against osteosarcoma tumor growth.
The Effect of Oryza Sativa&nbsp;L. Subsp.&nbsp;Japonica&nbsp;Cultivar Yukihikari on The Immune System
Authors: Adachi Takahiro , Kotake Kunihiko , Kato Kiyoaki , Tanimoto Kosuke , Munekata Shinya 
Published: November 2020

Abstract
Oryza sativa L. subsp. japonica cultivar Yuhikikari is proposed to alleviate atopic dermatitis, although its mechanism is unclear. To clarify this issue, we evaluated the effect of Yukihikari on the immune system in vitro and in vivo by comparison with another Japanese cultivar Kirara397. A DNA microarray analysis of mouse spleen cells cultured with either Yukihikari or Kirara397 showed that Yukihikari-added spleen cells exhibited significantly reduced expression of pro-inflammatory genes. Furthermore, another transcriptome analysis of the cultivars by RNA sequencing showed a similar result to the DNA microarray analysis. Mice fed with Yukihikari had less germinal center B cells, fewer autoantibodies, and less weight than those fed with Kirara397. These results suggest that Yukihikari has immune-regulatory functions and accounts for its allergy-ameliorating effects.
Surface Mass Balance Modelling at Naradu Glacier, Western Himalaya
Authors: Kumar Rajesh , Singh Shruti , Kumar Ramesh , Singh Atar , Singh Shaktiman , Randhawa Surjeet 
Published: November 2020

Abstract
In view of climate change, Himalayan glaciers are losing its mass. In present study we analyzed 7 year long field based data series of surface mass-balance measurements performed between 2011/12 and 2017/18 at Naradu glacier, western Himalaya. The average specific mass balance for the studied period was 0.83 m w.e. with a highest melting of 1.15 m w.e. The analysis of topographic features showed that south and southeast aspect along with the presence of debris cover area and the slope between 18 to 36 degree are the major factors which causes highest melting from a particular zone. For better understanding of SMB variability and its causes, multiple linear regression analyses (MLRA) was performed by taking temperature and precipitation as predictors. The temperature and precipitation records were taken from NASA GIOVANNI website. The MLRA shows that 71% of the variance of observed SMB can be explained by temperature and precipitation. The MLRA shows the importance of summer half-year temperature. This variable alone explains the 64% variance of observed SMB. The seasonal period analysis showed that with two predictor variables most of the SMB variability is described by summer temperature and winter precipitation. All monthly combinations show that SMB variance is best described by June temperature and September precipitation.
WITHDRAWN: The analysis of disruption management due to COVID-19 using business continuity management and house of risk on maritime operations
Authors: Budiyanto Eko Hariyadi , Gurning Raja Oloan Saut , Pitana Trika , Novalsyah Hafidz , Yudha Dwi , Mulyono  , Akbari Dany Rahmat , Ardarifa Daffa Amar , Fadilah Muhammad Arvin 
Published: November 2020

Abstract
The high frequency of shipping in Indonesia is directly proportional to the increase of port activities. Along with the activities, the risk of disruption that might occur also increase. The impact of a disruption can be detrimental to many parties such as crew, company, ship, cargo carried, and environment. During the COVID-19 pandemic, ports are encouraged to develop a plan that could minimize the disruption of the role that port play in keeping trade flowing and vital supplies moving. The possible impact from COVID-19 related disruption urges companies to apply the Business Continuity Management (BCM) system to deal with any potential disruption that might occur. This paper tries to identify and rank each potential disruption from COVID-19 based on severity & occurrence, House of Risk method was used with the aid of questionnaires and interviews. Furthermore, business impact analysis is conducted in order to analyse the impact of COVID-19 pandemic and how BCM helps to minimize the potential loss. Business continuity value also measured through analysing container throughput growth data.
Comprehensive Clinical Risk Management in a University Hospital: Implementation, Results and Outcome
Authors: Buchberger Wolfgang , Schmied Marten , Sarbu Anca , Siebert Uwe 
Published: November 2020

Abstract
BackgroundDespite the increasing awareness of the need to implement systematic methods to reduce treatment-related risks, there are only few studies on comprehensive clinical risk management (CRM) in hospitals. The aim of this study was to report on the implementation, results and outcome of a CRM system at a university hospital in Tyrol, Austria.MethodsCRM was rolled out in 35 departments of the hospital over a period of nine years and included the training of interdisciplinary risk management teams at each department, external and internal risk audits and the implementation of a critical incident reporting system (CIRS). The results of the risk audits were retrospectively reviewed and the risks identified were analyzed according to the type, severity and degree of implementation of risk management measures. Other key figures of CRM were obtained from the annual risk reports. The development of liability cases in the individual departments and in the entire hospital was used as an outcome measurement.ResultsOf the 1,104 risks identified during the risk audits, 620 (56.2%) were related to the organization of clinical care, 235 (21.3%) to documentation, 169 (15.3%) to patient treatment and 80 (7.2%) to patient information and consent. The highest proportion of serious risks was found in the category organization (22.7%), and the lowest in the category documentation (13.6%). The degree of implementation of prevention measures after 12 to 18 months was between 69.7% and 83.4% depending on the risk category. The CIRS identified between 241 and 370 critical incidents per year, for which in 79.5% to 83% preventive measures were implemented within twelve months.Compared with the years prior to the introduction of CRM, an average annual reduction of treatment-related harms by 52.9% (95% confidence interval, 44.2% to 61.6%) was observed at the end of the implementation phase. The mean number of harms per department and year dropped from 7.04 to 3.45 (p<0.001). ConclusionsThe results of this project demonstrate the effectiveness of systematic CRM in detecting treatment-related risks and in reducing harm to patients.
Poverty and Blind Religious Faith Preclude Attendance at Breast Cancer Screening in Mexico
Authors: Cerda-Flores Ricardo , Castellanos Enrique , Ancer-Arellano Jesús , Ristiniemi Jari , Márquez Marcela 
Published: November 2020

Abstract
BackgroundAttendance to mammography screening is low in Mexico with late breast cancer (BCa) intervention. This study investigates reasons for low attendance in screening programs. Socioeconomic and cultural factors were investigated. The present national BCa screening programs are discussed. MethodsThis is a cross-sectional study involving 1066 women in the Monterrey Metropolitan area. Women aged 40-79 years old with low-income/middle-income completed a questionnaire on socioeconomic and cultural factors. A descriptive and multivariate analysis was done.ResultsIn total, 27 percent had never attended mammography and about 61 percent had only done a mammography during the last 2 years. Sixty-seven percent of the women went to the doctor only when they "felt sick". The two principal reasons for not attending were financial (38%) and fatalism related to religious faith (80%). ConclusionsThis study, is the first to quantify both the socioeconomic and cultural factors in women in Mexico. It analyzes the relationship of the factors precluding BCa screening, seeking care for breast symptoms and subsequent treatment. LI and MI women belong to different socioeconomic and cultural subgroups in MMa. Affordable National state of the art prevention programs are needed, considering a heterogeneous population where the majority have low income/are poor. Tailored information on the importance of mammography attendance is needed where the Catholic Church could help to deliver information. Subsequent BCa treatment should be based on current guidelines. Trial registration﻿The Protocol was approved by the Ethic Committee, Hospital Metropolitano “Dr. Bernardo Sepulveda” Monterrey, Mexico, 5 October 2012.
A shorter equilibration period in the VitTrans in-straw bovine embryo vitrification method improves post-warming outcomes
Authors: Martínez-Rodero Iris , García-Martínez Tania , Ordóñez-León Erika Alina , Vendrell-Flotats Meritxell , Olegario-Hidalgo Carlos , Esmoris Joseba , Mendebil Xabier , Azcarate Sabino , López-Béjar Manel , Yeste Marc , Mogas Teresa 
Published: November 2020

Abstract
Background

VitTrans is a device that enables the vitrification and warming/dilution of in vitro produced bovine embryos followed by their direct transfer to recipient females in field conditions. This study sought to improve the VitTrans method by comparing two equilibration times: short (SE: 3 min) and long (LE: 12 min). Outcome measures recorded in vitrified D7 and D8 expanded blastocysts were survival and hatching rates, differential cell counts, apoptosis rate and gene expression.
Results

While survival rates at 3 h and 24 h post-warming were reduced (P < 0.05) after vitrification, hatching rates of D7 embryos vitrified after SE were similar to those obtained in fresh non-vitrified blastocysts. Hatching rates of vitrified D8 blastocysts were lower (P < 0.05) than of fresh controls, regardless of treatment. Total cell counts, and inner cell mass and trophectoderm cell numbers were similar in hatched blastocysts derived from D7 blastocysts vitrified after SE and fresh blastocysts, while vitrified D8 blastocysts yielded lower values, regardless of treatment. The rate of apoptotic cells was significantly higher in both treatment groups when compared to fresh controls, although apoptosis rates were lower using the SE than LE protocol. No differences emerged in expression of the genes BAX, AQP3, CX43 and IFNτ between blastocysts vitrified after SE or LE, whereas a significantly higher abundance of BCL2L1 and SOD1 transcripts was observed in blastocysts vitrified after SE compared to LE.
Conclusions

The VitTrans device combined with a shorter exposure to the equilibration medium improves vitrification/warming outcomes facilitating the direct transfer of vitrified embryos under field conditions.
Concerns and attitudes of patients with inflammatory bowel diseases during the COVID-19 pandemic
Authors: Chatzinikolaou Matina-Lydia , Zacharopoulou Eirini , Kokkotis Georgios , Palatianou Maria , Vogli Stamatina , Bamias Giorgos , Tzouvala Maria 
Published: November 2020

Abstract
Background: The coronavirus disease 2019 (COVID-19) pandemic has changed inflammatory bowel disease (IBD) care. The use of telemedicine was quickly adopted, however the impact of COVID-19 on IBD patients’ feelings and sense of security for their health has not been extensively evaluated.Aims: Our aim was to assess patients’ views and concerns regarding their IBD condition, compliance with treatment and preventive measures, accessibility to health services and sources of information they used during the coronavirus pandemic.Methods: A questionnaire-based survey of patients with IBD (n=237) was conducted at a University and an NHS GI Units.Results: Greek patients with IBD expressed high levels of fear of coronavirus infection, with more than 50% being afraid of dying as a result of COVID-19. Seven out of ten participants felt that their IBD medications increased risk of infection and this fear was significantly higher in patients on immunosuppression. Only 2% of patients discontinued treatment on their own, all of whom were receiving immunosuppression. More than 90% of participants reported staying home and washing their hands. Three quarters of patients had access to a doctor when needed and almost 50% used the electronic paperless prescription system. Participants were satisfied with the information they received regarding COVID-19. The main sources of information were media, internet and social networks, with only one third seeking guidance from their gastroenterologist. Conclusions: The COVID-19 pandemic had a profound, negative effect on IBD patients’ lives. COVID-19-related fears need to be actively addressed, particularly in IBD patients on immunosuppression, and relevant information should be continuously provided.
Presence and Persistence of Amblyomma Hebraeum Augments the Burden of Heartwater in the Southern District of Botswana
Authors: Ramotadima Isabella , Hyera Joseph , Lebani Kebaneilwe 
Published: November 2020

Abstract
BACKGROUNDHeartwater is a tick-borne, haemoparasitic disease that has the potential to limit the growth of agro-businesses in Botswana. This threat to national food security is attributed to low production and mortality of livestock in subsistence farming of small stock than in commercial farms. This study gives a view of the epidemiological burden of heartwater in Botswana. METHODSFeeding ticks on livestock kept in four Southern sub-districts of Botswana were identified through morphological and molecular analysis. Farmers were interviewed on the management of the heartwater burden within their respective sub-districts. Veterinary clinical case reports were collected to assess the frequency of cases across the Southern District of Botswana. RESULTSOutcomes of the study revealed; a wide distribution of Amblyomma hebraeum in all four studied sub-districts, gradual annual increase in heartwater cases in Moshupa sub-district and indication of increased impact on indigenous caprine species despite the effort to control vectors by 63% of interviewed farmers. CONCLUSIONAmblyomma hebraeum, the principal vector of Ehrlichia ruminantium in Southern Africa is widely distributed in the Southern District of Botswana and thus poses a challenge to livestock productivity in this district and, perhaps, elsewhere in the country where the tick infests livestock. There is therefore a need to re-examine the existing tick control interventions with an intention to reduce the heartwater disease burden particularly in sheep and goats.
A New Expression Model of Classical Electromagnetic Theory at the Micro Level
Authors: Fan Jack 
Published: November 2020

Abstract
Because Maxwell's classical electromagnetic theory is a macro-electromagnetic theory based on the cognition of the 19th century and before the 19th century, and because the physics of the 20th century has gained new cognition in the microscopic field, considering that it is now the 21st century. Therefore, this article attempts to establish a set of micro-expression theory of Maxwell's macro-electromagnetism theory based on the new cognitions obtained at the micro-level since the 20th century, in order to promote the further development of Maxwell's classical electromagnetism theory in accordance with the cognition of the times.