bluuebunny/crossref_metadata_2025_split huggingface dataset:
Property of ionic polymer metal composite with different thicknesses based on solution casting technique
Authors: Yang Liang , Zhang Dongsheng , Zhang Xining , Tian Aifen , He Miaomiao 
Published: October 2020

As an ionic electroactive polymer, ionic polymer metal composite (IPMC) has unique advantages and is widely used in various fields. However, the output force of IPMC is small, which further limits the application of IPMC. In this study, the Nafion520cs were selected as the preparation solution, and three ion-exchange polymer membranes (IEPMs) with different thicknesses (158, 256 and 383 [Formula: see text]m) were designed and prepared successfully by solution casting technique to study the output force. Then, three platinum electrodes-IPMCs (Pt-IPMCs) were fabricated using electroless plating method. The properties of Pt-IPMCs in terms of morphology, displacements and blocking forces were then evaluated under direct current voltage. The results showed that the prepared ionic membranes were uniform, transparent and flat, without accumulation or bubble. The platinum particles were preferably deposited on the surface, which promoted delivery of current through the IPMCs under the applied voltage, and improved the actuation performance. With the increase of voltage, the maximum displacement and maximum blocking force of the three IPMCs increased first and then decreased. When the voltage is 5.5 V, the maximum displacement for 158 um is 26 mm, while the maximum blocking force of 10.74 mN appears at 6.5 V for 383 um. It is necessary to select suitable thickness of IPMCs to adapt to different working environment and field, which provides a strong basis for further application of IPMCs.
Generation of (3, 1) Vector Signal Based on Probabilistic Shaping Technology without Precoding
Authors: Xiao Jiangnan , Dong Xu , Liu Bo , Feng Xingxing , Zhao Chuang , Zuo Jiangli 
Published: October 2020

In this paper, we introduce the probabilistic shaping (PS) technique to the normal (3, 1) vector signal and simulate the generated PS (3, 1) photonic vector signal on an optical transmission system. The PS (3, 1) photonic vector signal is generated by a radio frequency (RF) signal at 12 GHz driving a Mach–Zehnder modulator- (MZM-) based optical carrier suppression (OCS) doubling, and the PS (3, 1) photonic vector signal is not precoding. The PS (3, 1) photonic vector signal and the normal (3, 1) photonic vector signal are used to transmit in 5 km, 10 km, and 20 km single-mode fibers (SMF), respectively. The simulation results demonstrate that the bit error ratio (BER) of the PS (3, 1) vector signal is less than the forward error correction (FEC) threshold of 3.8

×

10−3, and the BER performance is better than that of the normal (3, 1) vector signal at 4 Gbit/s and 8 Gbit/s transmission rates.
Development and Validation of a Gene Signature Classifier for Consensus Molecular Subtyping of Colorectal Carcinoma in a CLIA-Certified Setting
Authors: Morris Jeffrey S. , Luthra Rajyalakshmi , Liu Yusha , Duose Dzifa Y. , Lee Wonyul , Reddy Neelima G. , Windham Justin , Chen Huiqin , Tong Zhimin , Zhang Baili , Wei Wei , Ganiraju Manyam , Broom Bradley M. , Alvarez Hector A. , Mejia Alicia , Veeranki Omkara , Routbort Mark J. , Morris Van K. , Overman Michael J. , Menter David , Katkhuda Riham , Wistuba Ignacio I. , Davis Jennifer S. , Kopetz Scott , Maru Dipen M. 
Published: October 2020

Abstract

Purpose:
Consensus molecular subtyping (CMS) of colorectal cancer has potential to reshape the colorectal cancer landscape. We developed and validated an assay that is applicable on formalin-fixed, paraffin-embedded (FFPE) samples of colorectal cancer and implemented the assay in a Clinical Laboratory Improvement Amendments (CLIA)-certified laboratory.

Experimental Design:
We performed an in silico experiment to build an optimal CMS classifier using a training set of 1,329 samples from 12 studies and validation set of 1,329 samples from 14 studies. We constructed an assay on the basis of NanoString CodeSets for the top 472 genes, and performed analyses on paired flash-frozen (FF)/FFPE samples from 175 colorectal cancers to adapt the classifier to FFPE samples using a subset of genes found to be concordant between FF and FFPE, tested the classifier's reproducibility and repeatability, and validated in a CLIA-certified laboratory. We assessed prognostic significance of CMS in 345 patients pooled across three clinical trials.

Results:
The best classifier was weighted support vector machine with high accuracy across platforms and gene lists (&gt;0.95), and the 472-gene model outperforming existing classifiers. We constructed subsets of 99 and 200 genes with high FF/FFPE concordance, and adapted FFPE-based classifier that had strong classification accuracy (&gt;80%) relative to “gold standard” CMS. The classifier was reproducible to sample type and RNA quality, and demonstrated poor prognosis for CMS1–3 and good prognosis for CMS2 in metastatic colorectal cancer (P &lt; 0.001).

Conclusions:
We developed and validated a colorectal cancer CMS assay that is ready for use in clinical trials, to assess prognosis in standard-of-care settings and explore as predictor of therapy response.
Julianus of Laodicea and His Astrological Fragments
Authors: László Levente 
Published: October 2020

Abstract
The present paper investigates the texts attributed to the astrological author Julianus of Laodicea. The authenticity of a work ascribed to him is re-examined, the genuine fragments are collected and evaluated, and possible further traces of his work in later literature are explored to correct and update his scholarly image. In an appendix, a critical edition of F18 is offered.
Princesses Born to Concubines: A First Visit to the Women of the Abbasid Household in Late Medieval Cairo
Authors: Banister Mustafa 
Published: October 2020

Abstract
This article presents a study of the women of the Abbasid household in 8th-/14th- and 9th-/15th-century Cairo. Following a discussion of the size and growth of the Abbasid family, the article juxtaposes a late fourteenth-century marriage document, which extolls the virtues of unions made with the caliph’s family, against the historical record of marriages made by Abbasid and non-Abbasid spouses in search of social capital. The study seeks to understand the meaning attached to marriages made with Abbasid family members, and the social advantages the caliphal family hoped to gain in return. By thus reconsidering the role of Abbasid concubines and princesses, we challenge preconceived notions about the agency and mobility of Abbasid family members in late medieval Cairo and demonstrate their freedom of movement in pursuing valuable marriage connections. The article is thus a contribution to broader understandings of notable women in premodern Islamicate societies.
Democratic Autonomy and the Shortcomings of Citizens
Authors: Lovett Adam 
Published: October 2020

Abstract
A widely held picture in political science emphasizes the cognitive shortcomings of us citizens. We’re ignorant. We don’t know much about politics. We’re irrational. We bend the evidence to show our side in the best possible light. And we’re malleable. We let political elites determine our political opinions. This paper is about why these shortcomings matter to democratic values. Some think that democracy’s value consists entirely in its connection to equality. But the import of these shortcomings, I argue, cannot be explained in purely egalitarian terms. To explain it, we must instead think of democracy’s value partly in terms of collective autonomy. Our ignorance and irrationality undermine the epistemic conditions for realizing this kind of autonomy. They stop us knowing the outcomes of our political choices. Our irrationality and malleability undermine the independence conditions for realizing such autonomy. They mean our political choices are subject to problematic kinds of interpersonal influence. Thus, at root, the import of the widely held picture is that, if accurate, it closes off this critical aspect of democracy’s value.
covid-19 Claims and the Law of International Responsibility
Authors: Paparinskis Martins 
Published: October 2020

Abstract
This paper considers the role that the law of international responsibility, both State responsibility and responsibility of international organizations, plays in claims and disputes about covid-19. It proceeds by examining in turn the rubrics of the internationally wrongful act, content of responsibility, and implementation of responsibility. On most points, blackletter law is perfectly capable of answering the questions raised by claims related to covid-19. But evolutionary potential inherent in the normal international legal process should also be recognised, whether it manifests itself by further strengthening current rules, elaborating vague rules by application, filling gaps in current law by generating new practice or even, exceptionally, revisiting rules currently in force.
Mercurius Ubiquitous
Authors: Swank Marisa 
Published: October 2020

Abstract
The purpose of this work is to construct a strong theoretical base for analytical psychology to engage with psychedelic therapy by drawing out tools already present in Jungian thought. This is done by first offering a brief history of psychedelic therapy and Jungian psychology, focusing on the work of three analysts. Stanislav Grof’s work with LSD therapy is then outlined and explored as a foundation for dialogue with Jungian concepts. Analytical psychology’s use of alchemical concepts and language is applied as a means of understanding psychedelic experience. Concepts of prima materia, Mercurius, the vessel, and subtle body are discussed alongside individuals’ accounts of their LSD sessions. Following these theoretical considerations, the author discusses the implications of a dialogue between analytical psychology and psychedelic therapy and potential future directions.
Reforming International Organizations
Authors: Heldt Eugénia C. , Mahrenbach Laura C. 
Published: October 2020

Abstract
Recent scholarship has highlighted the role of domestic pressures in determining state preferences toward the reform of international organizations (IO s). This article adds a new dimension by examining how partisanship and ministerial control affect state preferences toward IO empowerment. The article derives two expectations from the existing literature. First, partisan position will determine preferences toward IO empowerment. Second, when a government is constituted by multiple parties, the position of the party with the IO’s ministerial portfolio will determine the government’s position toward IO empowerment. The article illustrates this argument by examining the positions of four net donors (Germany, France, the United Kingdom, and the United States) and two net recipients (Brazil and India) during the World Bank’s reforms. By bringing domestic politics back in, this article complements existing studies on the politics of IO reform and weighs in on central debates in comparative politics and international political economy.
Revision of the genus Cyphura Warren, 1902. Part III: The geminia and semiobsoleta species groups from the Indo-Pacific region with five new species (Lepidoptera: Uraniidae: Uraniinae)
Authors: Sinnema Siep , Sinnema-Bloemen Jannie 
Published: October 2020

The geminia and semiobsoleta groups of the genus Cyphura
Warren, 1902 (Lepidoptera: Uraniidae) are revised. Five new species are described. There are four new species in the geminia species group: Cyphura pallidata sp. n., C. marcoi sp. n., C. aruensis sp. n., and C. numforensis sp. n. In this group, a lectotype is designated for Strophidia costalis
Butler, 1887, C. subsimilis

Warren, 1902, S. bifasciata
Butler, 1879, C. catenulata
Warren, 1902, Urapteroides approximans
Swinhoe, 1902, U. falka
Swinhoe, 1916, U. swinhoei
Rothschild, 1915 and for U. swinhoei
Joicey & Kaye, 1917. Six new synonyms are proposed: U. gutturalis (Swinhoe, 1916) is a junior synonym of C. geminia (Cramer, 1779), C. subsimilis
Warren, 1902 is a junior synonym of C. costalis (Butler, 1887), C. catenulata
Warren, 1902 and U. approximans (Swinhoe, 1902) are both junior synonyms of C. bifasciata (Butler, 1879), U. falka (Swinhoe, 1916) is a junior synonym of C. pieridaria
Warren, 1902 and U. swinhoei (Joicey & Kaye, 1917) is a junior synonym of C. maxima (Strand, 1912). Urapteroides swinhoei
Rothschild, 1915 is transferred to Cyphura as Cyphura swinhoei (Rothschild, 1915) comb. n.
In the semiobsoleta species group, one new species is described: C. trifasciata sp. n. In this group a lectotype is designated for Urapteroides semiobsoleta
Warren, 1896, U. semiobsoleta reducta
Joicey & Talbot 1916, C. multistrigaria
Warren, 1907 and for C. multistrigaria ab. dealbata
Warren, 1907.
Bangladeshi Poets Writing in English
Authors: Islam Mohammad Shafiqul 
Published: October 2020

Abstract
This article observes that Kaiser Haq has made an immense contribution to Bangladeshi poetry in English, leading the school of English poetry of the country from the front. A relatively new field, Bangladeshi writing in English has started becoming a part of world literature, and its scope, no doubt, is expanding rapidly. The article also focuses on the legacy of Bangladeshi writing in English to demonstrate how Bangladeshi poetry in English has simultaneously progressed. The article argues that Haq’s enormous contributions justify his position as the best English-language poet in Bangladesh. For his poetry, the poet takes material from his motherland and its rich culture, and his style, technique, and diction resonate with those of prominent poetic voices of the world. The article also sheds light on how Haq presents Bangladesh, depicting numerous shades of reality, and how he still dominates in the contemporary scene of Bangladeshi poetry in English.
Australia’s Atomic Past
Authors: Lowe David 
Published: October 2020

Abstract
I ask in this article whether the legacies of Australia’s nuclear past, including the great secrecy surrounding testing of weapons in the 1950s and 1960s, and subsequent clean-ups, have impacted in particular ways that have ongoing ramifications for policy relating to uranium mining and nuclear energy. My starting point is the sustained examination of the pros and cons of developing the nuclear fuel cycle in Australia, a Parliamentary Committee Inquiry from 2006. Contrasting the submissions and discussions of this committee with exhibition and educational materials relating to the legacies of atomic testing, I suggest that one of the biggest opportunities for constructive policy conversation on nuclear energy suffered from the absence of trust among different groups. This derived, in good measure, from distinctive features in popular remembering of Australia’s atomic past. In 2006, it fed the exasperation of nuclear advocates who did not, and perhaps still do not, appreciate that the neat separation of uranium mining and energy generation from Australia’s earlier encounters with the atom is very hard. Relatedly, I argue that the secrecy around governments’ involvement in atomic testing, and its legacies, is likely to be seized on regularly; and likely to sustain what is a reservoir of public mistrust of government policy.
Tropical Cyclones Downscaled from Simulations of the Last Glacial Maximum
Authors: Lawton Quinton A. , Korty Robert L. , Zamora Ryan A. 
Published: October 2020

AbstractThe tracks, intensities, and other properties of tropical cyclones downscaled from three models’ simulations of the Last Glacial Maximum (LGM) are analyzed and compared to those of storms downscaled from simulations of the present climate. Globally, the mean maximum intensity of storms generated from each model is lower at LGM, as is the fraction of all storms that reach intensities of category 4 or higher on the Saffir–Simpson hurricane wind scale. The median day of the storm season shifts earlier by an average of one week in all three models in both hemispheres. Two of the three models’ LGM simulations feature a reduction in storm count and global power dissipation index compared to the current climate, but a third shows no significant difference between the two climates. Although each model is forced by the same global changes, differences in the way sea surface temperatures and other large-scale environmental conditions respond in the North Atlantic impart significant differences in the climatology at LGM between models. Our results from the cold LGM provide a novel opportunity to assess how tropical cyclones respond to climate changes.
Surgical Supply Cost Awareness Is Associated With Lower Costs: A Single-Center Experience
Authors: Tseng Joshua , Sax Harry C. , Gewertz Bruce L. , Margulies Daniel R. , Alban Rodrigo F. 
Published: October 2020

Surgeons are often unfamiliar with the costs of surgical instrumentation and supplies. We hypothesized that surgeon cost feedback would be associated with a reduction in cost. A multidisciplinary team evaluated surgical supply costs for laparoscopic appendectomies of 7 surgeons (surgeons A-G) at a single-center academic institution. In the intervention, each surgeon was debriefed with their average supply cost per case, their partner’s average supply cost per case, the cost of each surgical instrument/supply, and the cost of alternatives. In addition, the laparoscopic appendectomy tray was standardized to remove extraneous instruments. Pre-intervention (March 2017-February 2018) and post-intervention (March 2018-October 2018) costs were compared. Pre-intervention, the surgeons’ average supply cost per case ranged from $754-$1189; when ranked from most to least expensive, surgeon A > B > C > D > E > F > G. Post-intervention, the surgeons’ average supply cost per case ranged from $676 to $846, and ranked from surgeon G > D > F > C > E > B > A. Overall, the average cost per case was lower in the post-intervention group ($854.35 vs. $731.11, P < .001). This resulted in savings per case of $123.24 (14.4%), to a total annualized savings of $29 151.
Feline musculoskeletal ageing: How are we diagnosing and treating musculoskeletal impairment?
Authors: Dowgray Nathalie , Comerford Eithne 
Published: October 2020

Practical relevance: An understanding of the process of musculoskeletal ageing – which all senior and geriatric cats will experience – is vital to maintaining the health and welfare of our ageing cat population. Clinical challenges: Assessment of the feline musculoskeletal system is not always straightforward. Diagnosis of impairment relies on input from owners and veterinarians in terms of visual observation, and clinical and orthopaedic examination, in addition to diagnostic imaging Audience: This review is written for the primary care veterinary team. Aims: The goals are to raise awareness and improve clinical diagnosis of musculoskeletal impairment as a result of ageing. The article also reviews therapeutic options and considers the evidence available for the prevention/deceleration of musculoskeletal ageing and impairment. Evidence base: There is good evidence of a high prevalence of osteoarthritis (OA) and degenerative joint disease (DJD) in older cats. There is also good evidence to indicate that functional impairment and chronic pain are sequelae of musculoskeletal disease. However, there is a paucity of information for what is best practice for the management and treatment of musculoskeletal impairment in a clinical situation. There is also a lack of evidence on how prevention of central stimulation of the nervous system caused by musculoskeletal impairment and, in turn the development of chronic pain, can be avoided.
Resistance to histone deacetylase inhibitors confers hypersensitivity to oncolytic reovirus therapy
Authors: Islam Shariful , Espitia Claudia M. , Persky Daniel O. , Carew Jennifer S. , Nawrocki Steffan T. 
Published: October 2020

AbstractDespite the promising antilymphoma activity of histone deacetylase (HDAC) inhibitors as a drug class, resistance is a significant clinical issue. Elucidating the molecular mechanisms driving HDAC inhibitor resistance and/or the specific targets that are altered in drug-resistant cells may facilitate the development of strategies that overcome drug resistance and are more effective for refractory patients. We generated novel T-cell lymphoma (TCL) cell line models of acquired resistance to the HDAC inhibitor belinostat to identify potential effective therapies. Belinostat-resistant cells displayed significant cross-resistance to other HDAC inhibitors including romidepsin, panobinostat, and vorinostat. Consistent with a lack of sensitivity to HDAC inhibitors, the resistant cells failed to induce increased acetylated histones. Drug-resistant cells featured significantly decreased expression of the key antiviral mediators IRF1 and STAT1. On the basis of these findings, we investigated the efficacy of the clinical formulation of reovirus (Reolysin) in parental and drug-resistant models. Our investigation revealed that HDAC inhibitor–resistant cells displayed enhanced vulnerability to reovirus replication and cell death in both in vitro and in vivo models compared with their parental counterparts. Importantly, Reolysin also significantly increased the antilymphoma activity of belinostat in HDAC inhibitor–resistant cells. Our data demonstrate that Reolysin alone or in combination with belinostat is a novel therapeutic strategy to treat TCL patients who develop resistance to HDAC inhibitors.
Analysing the meta-interaction between pathways by gene set topological impact analysis
Authors: Yan Shen , Chi Xu , Chang Xiao , Tian Mengliang 
Published: October 2020

Abstract
Background
Pathway analysis is widely applied in transcriptome analysis. Given certain transcriptomic changes, current pathway analysis tools tend to search for the most impacted pathways, which provides insight into underlying biological mechanisms. Further refining of the enriched pathways and extracting functional modules by “crosstalk” analysis have been proposed. However, the upstream/downstream relationships between the modules, which may provide extra biological insights such as the coordination of different functional modules and the signal transduction flow have been ignored.

Results
To quantitatively analyse the upstream/downstream relationships between functional modules, we developed a novel GEne Set Topological Impact Analysis (GESTIA), which could be used to assemble the enriched pathways and functional modules into a super-module with a topological structure. We showed the advantages of this analysis in the exploration of extra biological insight in addition to the individual enriched pathways and functional modules.

Conclusions
GESTIA can be applied to a broad range of pathway/module analysis result. We hope that GESTIA may help researchers to get one additional step closer to understanding the molecular mechanism from the pathway/module analysis results.