bluuebunny/crossref_metadata_2025_split huggingface dataset:
Energy-Efficient Time and Energy Resource Allocation in Non-selfish Symbiotic Cognitive Relaying Sensor Network with Privacy Preserving for Smart City
Authors: Li Ping , Liu Yu , Gao Xiang , Li Huibo , Gong Peng 
Published: August 2020

Abstract
Energy efficiency and privacy preserving have become essential for the wireless sensor networks. In the previous work, an optimal power allocation algorithm was investigated for a non-selfish symbiotic cognitive relaying scheme (NSCRS) in the sensor network with coexistence of a primary user (PU) and cognitive users (CUs). However, the optimal strategy of energy and time resource allocation as well as the privacy preserving was not considered. In this paper, we further consider the joint energy and time resource allocation problem for the cognitive users in NSCRS to maximize the overall capacity of the primary user and cognitive users with the consideration of information privacy under the energy constraints of cognitive users. With full channel state information (CSI), i.e., PU s -PU d , PU s -CUs and CUs-PU d , an optimal energy and time resource allocation algorithm is proposed based on the exhaustive searching. In order to reduce the overhead of CSI feedback, a suboptimal algorithm, in which only the instantaneous CSI of PU s -PU d , the instantaneous CSI of PU s -CUs and an averaged CSI of CUs-PU d by long term observation rather than an instantaneous value of CSI of CUs-PU d are required, is additionally proposed. Simulation results demonstrate the energy efficiency of primary and cognitive users in the NSCRS with consideration of information privacy can be greatly improved by the proposed algorithms.
COVID-19: What Can Iodine Maps From Perfusion CT Teach US? A Prospective Cohort Study.
Authors: Santamarina Mario G. , Riscal Dominique Boisier , Beddings Ignacio , Contreras Roberto , Baque Martiniano , Volpacchio Mariano , Lomakin Felipe Martinez 
Published: August 2020

Abstract
Background: Subtraction CT angiography (sCTA) is a technique used to evaluate pulmonary perfusion based on iodine distribution maps. The aim of this study is to assess lung perfusion changes with sCTA seen in patients with COVID-19 pneumonia, and correlate them with clinical outcomes.Material and Methods: A prospective cohort study was carried out with 45 RT-PCR-confirmed COVID-19 patients that required hospitalization at three different hospitals, between April and May 2020. In all cases, a basic clinical and demographic profile was obtained. Lung perfusion was assessed using sCTA. Evaluated imaging features included: Predominant type of perfusion abnormality (increased perfusion or hypoperfusion), perfusion abnormality distribution (focal or diffuse), extension of perfusion abnormalities (mild, moderate and severe involvement), presence of vascular dilatation and vascular tortuosity. All participants were followed-up until hospital discharge searching for the development of any of the study endpoints. These endpoints included intensive-care unit (ICU) admission, initiation of invasive mechanical ventilation (IMV) and death.Results: Forty-one patients (55.2 +/- 16.5 years, 22 men ) with RT-PCR-confirmed SARS-CoV-2 infection and an interpretable iodine map were included. Patients with perfusion anomalies on sCTA in morphologically normal lung parenchyma showed lower Pa/Fi values (294 ± 111.3 vs. 397 ± 37.7, p=0.035), and higher D-dimer levels (1156 ± 1018 vs. 378 ± 60.2, p<0.01). The patterns seen on lung CT were ground-glass opacities, mixed pattern and alveolar consolidation in 51.2%, 41.6% and 7.3%, respectively. Perfusion abnormalities were common (36 patients, 87.8%), mainly hypoperfusion in areas of apparently healthy lung . Patients with severe hypoperfusion in areas of apparently healthy lung parenchyma had an increased probability of being admitted to ICU and to initiate IMV (HR of 11.9% and HR 7.8%, respectively).Conclusion: Perfusion abnormalities evidenced in iodine maps obtained by sCTA are associated with increased admission to ICU and initiation of IMV in COVID-19 patients.
Intravenous immunoglobulin treatment for patients with severe COVID-19: a retrospective multi-center study
Authors: Liu Jiao , Chen Yizhu , Li Ranran , Dong Xuan , Li Yizhong , Xu Qianghong , Feng Huibin , Huang Sisi , Guo Jun , Zhang Lidi , Ye Xiaofei , Zhu Wei , Du Hangxiang , Liu Yong’an , Wang Tao , Chen Limin , Wen Zhenliang , Teboul Jean-Louis , Chen Dechang 
Published: August 2020

Abstract
Background: Intravenous immunoglobulin (IVIG) is commonly used to treat severe COVID-19, although the clinical outcomes remain unclear. This study evaluated the effectiveness of IVIG treatment for severe COVID-19.Methods: This retrospective multi-center study evaluated 28-day mortality and time for SARS-CoV-2 RNA clearance in severe COVID-19 patients with or without IVIG treatment. Propensity score matching was used to control confounding factors. Logistic regression and competing risk analyses were performed.Results: The study included 850 patients (421 patients received IVIG). No significant differences in 28-day mortality or time for SARS-CoV-2 RNA clearance were observed (p=0.357 and p=0.123, respectively). High-dose of IVIG treatment (>10 g/day) (n=27) was associated with decreased 28-day mortality (OR: 0.33, 95% CI: 0.14–0.77; p=0.011). The IVIG group had prolonged median hospitalization, less shock, and higher incidences of acute respiratory distress syndrome, myocardial injury. Furthermore, IVIG-treated patients were more likely to require non-invasive mechanical ventilation and less likely to require invasive mechanical ventilation.Conclusions: IVIG treatment for severe COVID-19 patients was not associated with significant improvements in 28-day mortality or time for SARS-CoV-2 RNA clearance. However, some improvements in 28-day survival were observed for high-dose IVIG treatment (>10 g/day).
Automatic Detection of Liver Disease Using Voting Ensemble Method
Authors: Dutta Shawni , Bandyopadhyay Prof. Samir Kumar 
Published: August 2020

Abstract
Liver disease is one of the prominent causes of death which can be tackled by providing detection at an early stage along with possible countermeasures. Liver diseases caused by factors like genetic predisposition, infections and the environment. It requires diverse and targeted treatment options. The increasing of hepatic conditions worldwide is due to lifestyle actions such as intake of alcohol and drug with the consultation of physicians. The cause of numerous infections and disorders are not yet well understood. A voting ensemble method is proposed in this paper that considers influential factors responsible for liver disease. This predictive model aims to enhance forecasting reports with respect to other peer intelligent model. The enhanced efficiency reaches an accuracy of 77.2% which is quite promising towards early liver disease prediction.
Montmorillonite combined organic acid or essential oil complex improves the intestinal health status of laying hens
Authors: Chen Jifa , Geng Xiaofeng , Ali Ali Seif 
Published: August 2020

Abstract
Background: This study was conducted to evaluate the effects of montmorillonite combined organic acid (MOA) complex and montmorillonite combined essential oil (MEO) complex on the laying performance and intestinal barrier functions in laying hens. Methods: Two hundred and seventy 29-wk-old laying hens were randomly assigned to 3 treatments consisted of 6 replicates of 15 hens, receiving the following diets for 10 wks, respectively: 1) basal diet; 2) the basal diet added with 0.65 g/kg of MOA complex; 3) the basal diet added with 0.70 g/kg of MEO complex. Results: Dietary supplementation with both MOA and MEO complexes tended to increase (P = 0.094) the hens’ egg production and improved numerically (P > 0.05) the egg mass and feed conversion ratio during 6–10 weeks of the experiment. Dietary MOA and MEO complexes decreased (P < 0.05) the relative amount of Clostridium perfringens and the mRNA expression levels of myeloid differentiation factor 88 (MyD88) and interleukin‐1 beta (IL-1β) in the ileum while increased (P < 0.05) the activity of suctase and villus height-to-crypt depth ratio of the ileum. Besides, dietary inclusion of MEO complex increased (P < 0.05) the mRNA expression level of claudin-5 in the ileum. The MOA complex supplementation reduced (P < 0.05) the relative amount of Salmonella and nuclear factor kappa B P65 (NF-κB p65) mRNA expression level of the ileum but enhanced (P < 0.05) the alkaline phosphatase activity in the ileum and villus height-to-crypt depth ratio of the jejunum. Conclusions: Dietary both MOA and MEO complexes could improve the intestinal health status of laying hens, which may contribute to the partially increase in hens’ laying performance.
Reappraisal of Trifluperidol against NSP-3 protein: Potential therapeutic for COVID-19
Authors: Pandey Ajita 
Published: August 2020

Abstract
Novel coronavirus disease 2019 (COVID-19) is a highly infectious disease that is caused by the recently discovered severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Because there are no specific vaccines or drugs for SARS-CoV-2, drug repurposing may be a promising approach. SARS-CoV-2 has a positive-sense RNA genome that encodes non-structural proteins (Nsps), which are essential for viral replication in the host cell. Non-structural protein 3 (Nsp3) is a multidomain protein and is the largest protein of the replicase complex. Nsp3 contains an ADP-ribose phosphatase (ADRP) domain, also called the macrodomain, which interferes with the host immune response. In the present study, we used computational regression methods to target the ADRP domain of Nsp3, using FDA-approved drugs. We virtually screened 2,892 FDA-approved drugs, using a combination of molecular docking and scoring functions. Saquinavir and trifluperidol were identified as potential leads and were further investigated using molecular dynamics simulation (MDS) to predict the stability and behavior of the ADRP-drug complexes. Analysis of root mean square deviation, root mean square fluctuation, radius of gyration, solvent accessible surface area and number of hydrogen bonds showed that the ADRP-trifluperidol complex is more stable than the ADRP-saquinavir complex. The screening and the MDS results suggest that trifluperidol is a novel inhibitor of the ADRP domain of Nsp3. Trifluperidol could, therefore, potentially be used to help control the spread of COVID-19, either alone or in combination with antiviral agents. Further in-vitro and in-vivo experiments are necessary to confirm our in silico results.
Sustainable Water Management using Rainfall Runoff Modeling: A Geospatial Approach
Authors: Shyam Gara Megha , Sudhanshu  , Singh Suraj Kumar 
Published: August 2020

Abstract
In earth crust, precipitation is one of the dynamic hydrologic cycle. It is an ideal unit of natural resource like water from precipitation. In present days, Remote Sensing technology (RS) in association with Geographic Information system (GIS) has become a very important in innovation of technology in all fields of Engineering. Because these techniques enable us results with high accuracy in less time. Digital Elevation Model (DEM) is one of the most effective models, to delineate stream network map with flow direction, stream density and watersheds. The rainfall runoff is estimated by using Lacy’s and Rational formula. To identify the feasible locations for excess precipitation water to the ground water regime by the help of Rain Water Harvesting systems (RWH), evaluate total recharge potential through these systems and its impact on ground water regime. This research paper provides a scientific approach to arrest the maximum possibility of precipitation runoff during rainfall event and also the conservation of water with ground water recharge, in the area of studied.
A New Simulation-based Robust Optimal Design of FOPID Controller for Five Bar Linkage Robot in a Cyber-physical System
Authors: Parnianifard Amir , Wuttisittikulkij Lunchakorn , Zemouche Ali , Phanomchoeng Gridsada 
Published: August 2020

Abstract
This paper aims to further increase the reliability of optimal results by setting the simulation conditions to be as close as possible to the real or actual operation to create a Cyber-Physical System (CPS) view for the installation of the Fractional-Order PID (FOPID) controller. For this purpose, we consider two different sources of variability in such a CPS control model. The first source refers to changeability of a target of control model (multiple setpoints) because of environmental noise factors and the second source refers to an anomaly in sensors that is raised in a feedback loop. We develop a new approach to optimize two objective functions under uncertainty including signal energy control and response error control while obtaining the robustness among the source of variability with the lowest computational cost. A new hybrid surrogate-metaheuristic approach is developed using Particle Swarm Optimization (PSO) to update the Gaussian Process (GP) surrogate for a sequential improvement of the robust optimal result. The application of efficient global optimization is extended to estimate surrogate prediction error with less computational cost using a jackknife leave-one-out estimator. This paper examines the challenges of such a robust multi-objective optimization for FOPID control of a five-bar linkage robot manipulator. The results show the applicability and effectiveness of our proposed method in obtaining robustness and reliability in a CPS control system by tackling required computational efforts.
Effects of Metabolic Syndrome on Renal Function After Radical Nephrectomy in Patients with Renal Cell Carcinoma
Authors: Zhang Yong , Wu Tingkun , Xie Jingjing , Yan Liqun , Guo Xiuli , Xu Weijia , Wang Liping 
Published: August 2020

Abstract
Background: Nephrectomy, partial or radical, remains the standard treatment for renal cell carcinoma (RCC). However, increased risk of chronic kidney disease (CKD) must still be considered. This study aimed to evaluate the effects of concomitant metabolic syndrome (MetS) on renal function in patients with RCC after radical nephrectomy.Methods: Medical records of 310 patients who underwent radical nephrectomy for clear-cell RCC at 900th Hospital of the Joint Logistics Support Force, PLA from December 2012 to January 2017 were reviewed retrospectively. Estimated glomerular filtration rate (eGFR) and CKD stages were calculated at one week preoperative as baseline and then at postoperative 1 week, 3 months, 12 months and 24 months. MetS patients were identified and enrolled in the MetS group (n=31), and a non-MetS group was selected by propensity score matching (n=31). Non-neoplastic renal parenchyma specimens taken at least 2 cm from edge of tumor were evaluated.Results: Baseline characteristics between the two groups were comparable. At 24 months postoperative, mean eGFR levels of the MetS group were significantly lower than those in the non-MetS group (62.7 vs. 73.3 ml/min/1.73m2; p=0.004). CKD stages were still more severe in the MetS group than those in the non-MetS group (p = 0.006). The proportions of global sclerosis, tubular atrophy and interstitial fibrosis were all significantly more prevalent in MetS patients, compared to non-MetS patients (all p<0.05).Conclusion: In RCC patients with MetS, the possibility of declining eGFR and CKD progression must be considered after radical nephrectomy. Routine monitoring of renal function must be emphasized.
Metabolic Syndrome among Adults in Jordan: Prevalence, Trend, and Associated Factors
Authors: Ajlouni Kamel , Khader Yousef , Alyousfi Mohamad , Nsour Mohannad Al , Batieha Anwar , Jaddou Hashem 
Published: August 2020

Abstract
Background: Metabolic Syndrome is emerging as a global health challenge in the 21st century. Multiple epidemiological studies were conducted among variety of ethnic groups showed discrepancies in the prevalence of both Metabolic Syndrome and its individual components. The aims of this study were to determine the prevalence of Metabolic Syndrome in Jordan using the ATP III and IDF criteria and assess the changes of Metabolic Syndrome prevalence over time. Methods: Data from the 2017 cardiovascular risk factors national survey were. The survey collected extensive data from a national population-based sample of Jordanian residents. A structured questionnaire was used to collect sociodemographic variables and clinical data. Blood samples were taken for biochemical measurements. Anthropometric characteristics were measured by the same team of trained field researchers. A total sample of 4,056 aged between 18 and 90 years were included. The findings from the 2017 survey were compared with the findings of the 2009 survey that adopted the same methods and procedures. Results: The crude prevalence of Metabolic Syndrome was 48.2% (52.9% among men and 46.2% among women; p<0.001) according to IDF criteria. Using the ATP III criteria, the prevalence was 44.1% (51.4% among men and 41% among women, p<0.001). The age standardized prevalence rate of Metabolic Syndrome was 44% (95% CI: 42.7%, 45.4%) and 39.9% (95% CI: 39.6%, 41.2%) using the IDF definition and ATP III criteria, respectively. The kappa measure of agreement showed excellent agreement between the two definitions (k= 81.9%, p<0.001). Of all participants, 41.7% met both the IDF and ATP III diagnostic criteria, 6.6% met the IDF criteria only and 2.5% met the ATP III criteria only. The age-standardized prevalence rate of Metabolic Syndrome was significantly higher in 2017 (45.7% in men and 44.5% in women) than that in 2009 (34.6% in men and 39.8% in women).Conclusion: The prevalence of Metabolic Syndrome in Jordan is considerably high and increasing. Healthy lifestyle programs encouraging appropriate dietary habits and physical activity are strongly recommended in Jordan.
miR-636 Inhibits EMT, Cell Proliferation and Cell Cycle of Ovarian Cancer by Directly Targeting the Transcription Factor Gli2 of Hedgehog Pathway
Authors: Ma Jiong , Zhou Chunxia , Chen Xuejun 
Published: August 2020

Abstract
Objective: Ovarian cancer (OVC) is the fifth leading cause of cancer-related deaths in women and has a significant impact on physical and mental health of women. This study explores the molecular mechanism of miR-636 acting as a tumor suppressor in OVC in vitro and in vivo, and provides new insight into the treatment of OVC.Methods: Protein-protein interaction (PPI) analysis was performed to identify the hub gene in Hedgehog (Hh) pathway. TargetScan database was used to predict the upstream regulatory miRNAs of Gli2 to obtain the target miRNA. qRT-PCR was performed to test the expression of miR-636, while Western blot were conducted to detect the expression of Hh and EMT (epithelial-mesenchymal transition) related genes in OVC cell lines. MTT assay and wound healing assay were used to measure the effect of miR-636 on OVC cell proliferation and migration. Flow cytometry was carried out to examine the effect of miR-636 on cell cycle, and Western blot was used for identification of changes in expression of Hh and EMT related proteins. Dual-luciferase reporter gene assay was implemented to detect the targeted relationship between miR-636 and Gli2. The xenotransplantation model was used to detect the effect of miR-636 on OVC cell proliferation in vivo.Results: PPI interaction analysis found that Gli2 was the hub gene in Hh pathway. Based on TargetScan and GEO databases, Gli2 was found to be targeted regulated by the upstream miR-636. In vitro experiments discovered that miR-636 was significantly lowly expressed in OVC cell lines. Overexpressing miR-636 significantly inhibited HO-8910PM cell proliferation and migration abilities as well as induced cell cycle arrest in G0/G1 phase, while the inhibition of miR-636 promoted cell proliferation and migration abilities. Dual-luciferase reporter gene assay revealed that Gli2 was a target gene of miR-636. Besides, overexpressing miR-636 decreased protein expression of Gli2, while the inhibition of miR-636 increased protein expression of Gli2. Furthermore, the overexpression and inhibition of miR-636 both affected the expression of proteins related to Hh signaling pathway and EMT. Rescue experiments verified that overexpression of Gli2 reversed the inhibitory effect of miR-636 on HO-8910PM cell proliferation and migration abilities, and attenuated the blocking effect of miR-636 on HO-8910PM cell cycle. The xenotransplantation model suggested that miR-636 inhibited cell growth of OVC by decreasing Gli2 expression. Besides, overexpressing Gli2 potentiated the EMT process in OVC via decreasing E-cadherin protein expression and increasing Vimentin protein expression, and it reversed the inhibitory effect of miR-636 on OVC cell proliferation and migration abilities in vivo.Conclusion: miR-636 inhibits the Hh pathway activation via targeted binding to Gli2, thus inhibiting EMT, cell proliferation and migration in OVC.
Factors Related to Reamputation in Patients with Diabetes Who Have Undergone Minor Amputation: A Single-Facility Retrospective Cohort Study
Authors: Imaoka Shinsuke , Sato Koji , Furukawa Masahide , Okita Minoru , Higashi Toshio 
Published: August 2020

Abstract
Background: With aging, there has been an increase in the number of patients with lower limb amputations, especially in Japan. Previous studies have reported that minor amputation after limb salvage is associated with a high recurrence, with the ulcer recurring within 10.5 months. Age, wounded area, history of peripheral artery disease, and wound infection have been reported as the risk factors of recurrence. Thus far, there are no studies on the association between rehabilitation and reamputation. This study therefore aimed to examine factors predictive of reamputation in patients with diabetes who have undergone minor amputation for developing a rehabilitation program.Methods: This study included 129 patients who had undergone physical therapy between January 2015 and February 2018. The patients were assigned to the reamputation and non-reamputation groups. We retrospectively studied the patients’ medical records and compared the factors between the groups. Next, we analyzed the differences between the factors using Cox proportional hazards analysis.Results: During the follow-up period, 42 patients (35.2%) underwent reamputation. The factors associated with reamputation were hemodialysis, ankle dorsiflexion angle, and ambulation Functional Independence Measure score.Conclusions: We identified hemodialysis, ankle dorsiflexion angle, and FIM ambulation were the factors associated with reamputation in patients with diabetes who had undergone minor amputation． Future developing a rehabilitation program focusing on these factors could reduce reamputations.