bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postoperative recurrence of chronic subdural hematoma is more frequent in patients with blood type A
Authors: Hirai Satoshi , Yagi Kenji , Hara Keijiro , Kanda Eiichiro , Matsubara Shunji , Uno Masaaki 
Published: January 2021

OBJECTIVEBecause of an aging society, the incidence of chronic subdural hematoma (CSDH) is increasing. This lesion is treated with simple burr hole irrigation, but one of the major issues is that CSDH frequently recurs. ABO blood type may be associated with a bleeding tendency and inflammation. However, its association with the recurrence of CSDH remains unknown. Therefore, the authors of the present study aimed to retrospectively investigate the association between ABO blood type and CSDH recurrence.METHODSThe authors retrospectively analyzed symptomatic CSDHs in 425 cerebral hemispheres of 376 patients who had undergone surgical treatment with irrigation of the hematoma via burr holes at their institution from January 2011 to September 2019. Among these were 366 CSDHs in 320 patients whose ABO blood type had been determined and who were included in this study.RESULTSIn the study, 307 patients with CSDHs in 350 hemispheres were followed up postoperatively until the disappearance of the CDSH or for at least 3 months. Recurrence of CSDH was observed in 37 patients (10.6%) after surgical treatment. Blood type A was found to be significantly associated with CSDH recurrence compared to non-A blood types: 24 of 153 CDSHs (15.7%) versus 13 of 197 CDSHs (6.6%) (p = 0.008). In the multivariable regression analysis, blood type A, in addition to thrombocytopenia, was a significant independent predictor of the recurrence of CSDH.CONCLUSIONSThe study results showed that blood type A is an independent risk factor for the postoperative recurrence of CSDH and that careful follow-up in these patients may be needed.
Basal ganglia cavernous malformations: case series and systematic review of surgical management and long-term outcomes
Authors: Li Yiping , Khahera Anadjeet , Kim Jason , Mandel Mauricio , Han Summer S. , Steinberg Gary K. 
Published: January 2021

OBJECTIVEReports on basal ganglia cavernous malformations (BGCMs) are rare. Here, the authors report on their experience in resecting these malformations to offer insight into this infrequent disease subtype.METHODSThe authors retrospectively reviewed a prospectively managed departmental database of all deep-seated cerebral cavernous malformations (CCMs) treated at Stanford between 1987 and 2019 and included for further analysis those with a radiographic diagnosis of BGCM. Moreover, a systematic literature review was undertaken using the PubMed and Web of Science databases.RESULTSThe departmental database search yielded 331 patients with deep-seated CCMs, 44 of whom had a BGCM (13.3%). Headache was the most common presenting sign (53.5%), followed by seizure (32.6%) and hemiparesis (27.9%). Lesion location involved the caudate nucleus in 21.4% of cases compared to 78.6% of cases within the lentiform nucleus. Caudate BGCMs were larger on presentation and were more likely to present to the ependymal surface (p < 0.001) with intraventricular hemorrhage and hydrocephalus (p = 0.005 and 0.007, respectively). Dizziness and diplopia were also more common with lesions involving the caudate. Because of their anatomical location, caudate BGCMs were preferentially treated via an interhemispheric approach and were less likely to be associated with worsening perioperative deficits than lentiform BGCMs (p = 0.006 and 0.045, respectively). Ten patients (25.6%) were clinically worse in the immediate postoperative period, 4 (10.2%) of whom continued to suffer permanent morbidity at the last follow-up. A long-term good outcome (modified Rankin Scale [mRS] score 0–1) was attained in 74.4% of cases compared to the 69.2% of patients who had presented with an mRS score 0–1. Relative to their presenting mRS score, 89.8% of patients had an improved or unchanged status at the last follow-up. The median postoperative follow-up was 11 months (range 1–252 months). Patient outcomes after resection did not differ among surgical approaches; however, patients presenting with hemiparesis and lesions involving the globus pallidus or posterior limb of the internal capsule were more likely to suffer neurological deficits during the immediate perioperative period. Patients who had undergone awake surgeries were more likely to suffer neurological decline at the early as well as the late follow-up. When adjusting for awake craniotomy as a potential confounder of lesion location, a BGCM involving the posterior limb was predictive of developing early postoperative deficits, but this finding did not persist at the long-term follow-up.CONCLUSIONSSurgery is a safe and effective treatment modality for managing BGCMs, with an estimated long-term permanent morbidity rate of around 10%.
Mapping efficacious deep brain stimulation for pediatric dystonia
Authors: Coblentz Ailish , Elias Gavin J. B. , Boutet Alexandre , Germann Jurgen , Algarni Musleh , Oliveira Lais M. , Neudorfer Clemens , Widjaja Elysa , Ibrahim George M. , Kalia Suneil K. , Jain Mehr , Lozano Andres M. , Fasano Alfonso 
Published: January 2021

OBJECTIVEThe objective of this study was to report the authors’ experience with deep brain stimulation (DBS) of the internal globus pallidus (GPi) as a treatment for pediatric dystonia, and to elucidate substrates underlying clinical outcome using state-of-the-art neuroimaging techniques.METHODSA retrospective analysis was conducted in 11 pediatric patients (6 girls and 5 boys, mean age 12 ± 4 years) with medically refractory dystonia who underwent GPi-DBS implantation between June 2009 and September 2017. Using pre- and postoperative MRI, volumes of tissue activated were modeled and weighted by clinical outcome to identify brain regions associated with clinical outcome. Functional and structural networks associated with clinical benefits were also determined using large-scale normative data sets.RESULTSA total of 21 implanted leads were analyzed in 11 patients. The average follow-up duration was 19 ± 20 months (median 5 months). Using a 7-point clinical rating scale, 10 patients showed response to treatment, as defined by scores < 3. The mean improvement in the Burke-Fahn-Marsden Dystonia Rating Scale motor score was 40% ± 23%. The probabilistic map of efficacy showed that the voxel cluster most associated with clinical improvement was located at the posterior aspect of the GPi, comparatively posterior and superior to the coordinates of the classic GPi target. Strong functional and structural connectivity was evident between the probabilistic map and areas such as the precentral and postcentral gyri, parietooccipital cortex, and brainstem.CONCLUSIONSThis study reported on a series of pediatric patients with dystonia in whom GPi-DBS resulted in variable clinical benefit and described a clinically favorable stimulation site for this cohort, as well as its structural and functional connectivity. This information could be valuable for improving surgical planning, simplifying programming, and further informing disease pathophysiology.
Etiology of intracerebral hemorrhage in children: cohort study, systematic review, and meta-analysis
Authors: Boulouis Grégoire , Stricker Sarah , Benichi Sandro , Hak Jean-François , Gariel Florent , Alias Quentin , de Saint Denis Timothée , Kossorotoff Manoelle , Bajolle Fanny , Garzelli Lorenzo , Beccaria Kevin , Paternoster Giovanna , Bourgeois Marie , Garcelon Nicolas , Harroche Annie , Mancusi Rossella Letizia , Boddaert Nathalie , Puget Stephanie , Brunelle Francis , Blauwblomme Thomas , Naggara Olivier 
Published: January 2021

OBJECTIVEUnderstanding the etiological spectrum of nontraumatic pediatric intracerebral hemorrhage (pICH) is key to the diagnostic workup and care pathway. The authors aimed to evaluate the etiological spectrum of diseases underlying pICH.METHODSChildren treated at the authors’ institution for a pICH were included in an inception cohort initiated in 2008 and retrospectively inclusive to 2000, which was analyzed in October 2019. They then conducted a systematic review of relevant articles in PubMed published between 1990 and 2019, identifying cohorts with pICH. Identified populations and patients from the authors’ cohort were pooled in a multicategory meta-analysis.RESULTSA total of 243 children with pICH were analyzed in the cohort study. The final primary diagnosis was an intracranial vascular lesion in 190 patients (78.2%), a complication of a cardiac disease in 17 (7.0%), and a coagulation disorder in 14 (5.8%). Hematological and cardiological etiologies were disproportionately more frequent in children younger than 2 years (p < 0.001). The systematic review identified 1309 children in 23 relevant records pooled in the meta-analysis. Overall, there was significant heterogeneity. The dominant etiology was vascular lesion, with an aggregate prevalence of 0.59 (95% CI 0.45–0.64; p < 0.001, Q = 302.8, I2 = 92%). In 18 studies reporting a detailed etiological spectrum, arteriovenous malformation was the dominant etiology (68.3% [95% CI 64.2%–70.9%] of all vascular causes), followed by cavernoma (15.7% [95% CI 13.0%–18.2%]).CONCLUSIONSThe most frequent etiology of pICH is brain arteriovenous malformation. The probability of an underlying vascular etiology increases with age, and, conversely, hematological and cardiac causes are dominant causes in children younger than 2 years.
Association of intravenous administration of human Muse cells with deficit amelioration in a rat model of spinal cord injury
Authors: Kajitani Takumi , Endo Toshiki , Iwabuchi Naoya , Inoue Tomoo , Takahashi Yoshiharu , Abe Takatsugu , Niizuma Kuniyasu , Tominaga Teiji 
Published: January 2021

OBJECTIVE
Multilineage-differentiating stress-enduring (Muse) cells are pluripotent stem cells, which can be harvested from the bone marrow. After transplantation, Muse cells can migrate to an injured site of the body and exert repair effects. However, it remains unknown whether Muse cell transplantation can be an effective treatment in spinal cord injury (SCI).

METHODS
The authors used a rat model of thoracic spinal cord contusion injury. For Muse cell transplantation, the clinical product CL2020 containing 300,000 Muse cells was administered intravenously 1 day after midthoracic SCI. Animals were divided into CL2020 (n = 11) and vehicle-treated (n = 15) groups. Behavioral and histological evaluations were conducted over a period of 8 weeks to see whether intravenous CL2020 administration provided therapeutic effects for SCI. The effects of human-selective diphtheria toxin on reversion of the therapeutic effects of CL2020 were also investigated.

RESULTS
Hindlimb motor function significantly improved after CL2020 transplantations. Importantly, the effects were reverted by the human-selective diphtheria toxin. In immunohistochemical analyses, the cystic cavity formed after the injury was smaller in the CL2020 group. Furthermore, higher numbers of descending 5-hydroxytryptamine (5-HT) fibers were preserved distal to the injury site after CL2020 administration. Eight weeks after the injury, Muse cells in CL2020 were confirmed to differentiate most predominantly into neuronal cells in the injured spinal cord.

CONCLUSIONS
Following SCI, Muse cells in CL2020 can reach the injured spinal cord after intravenous administration and differentiate into neuronal cells. Muse cells in CL2020 facilitated nerve fiber preservation and exerted therapeutic potential for severe SCI.
Venezuela en el comercio internacional y frente al desarrollo sustentable.
Authors: Morillo Moreno Marysela Coromoto 
Published: January 2021

Â Venezuela pese a los innumerables dotes naturales no ha podido alcanzar el anhelado desarrollo, tampoco el bienestar de todos sus habitantes, en parte porque sus acciones y prácticas económicas no se han fundamentado en el desarrollo sustentable, su comercio exterior se limita a la exportación de materias primas básicas sin mucho valor agregado cuya explotación intensiva incrementa la vulnerabilidad ecológica irreversible. En el presente trabajo se analiza la economía venezolana en el marco del desarrollo sustentable, vinculando su participación en el comercio exterior con el desarrollo sustentable. Se recomienda la urgente reducción de la dependencia petrolera, la diversificación económica y de exportaciones, para participar en el comercio internacional de forma dinámica con productos de alto valor agregado. El reto son los procesos de liberalización comercial y mundialización que promueva la sustentabilidad ecológica y el desarrollo humano equitativo, integrando mundialmente las políticas ecológicas y comerciales, dado que el comercio internacional no necesariamente eleva la calidad de vida y la salud del planeta, por el contrario, todo depende del uso eficiente de los recursos para crear riquezas en concordancia con la protección del medio ambiente.
Esquema conceptual para el desarrollo de líderes operacionales
Authors: Mendoza de Ferrer Ermelinda 
Published: January 2021

En el mundo de rápido y continuo cambio que le ha tocado vivir a las organizaciones de hoy, se hace necesario diseñar sistemas de apoyo que contribuyan a mejorar la apacidad de respuesta a las demandas del entorno, siendo una de las estrategias el desarrollo del capital humano, de allí que, este artículo tiene como objetivo general, presentar un Â Â quema conceptual para el desarrollo de líderes operacionales en función de los resultados obtenidos en la evaluación del programa de desarrollo supervisorio Â mplementado en una corporación venezolana con miras a mejorar su competitividad. El diseño fue de tipo transeccional descriptivo, el universo investigado fue de 303 sujetos que habían participado en el programa a ser evaluado. La muestra fue de 82 participantes para lograr una precisión igual a 0,1. Se utilizó la técnica de entrevista estructurada. La validez de contenido se obtuvo por juicio de expertos. Como resultado, se evidenció la existencia de modelos de comportamiento organizacional limitantes del desarrollo del perfil deseado. Se recomienda un esquema conceptual para la formación de líderes operacionales apoyado en el sistema socio-estructural y justificado por el sistema cultural de la organización..Â Â
ANALISIS SPASIAL DAN TEMPORAL KEJADIAN DBD DI KOTA SEMARANG TAHUN 2016-2019
Authors: Alfiyanti Ufa Nor , Siwiendrayanti Arum 
Published: January 2021

Abstrak: Analisis Spasial dan Temporal Kejadian DBD di Kota Semarang Tahun 2016-2019. Jumlah kasus DBD di Kota Semarang pada tahun 2016-2019 secara berurutan yaitu IR 25,27 / 100.000 penduduk pada tahun 2016, IR 18,14 / 100.000 penduduk pada tahun 2017, IR 6,17 / 100.000 penduduk pada tahun 2018, dan IR 26,37 / 100.000 penduduk pada tahun 2019. Terjadi kenaikan Kasus DBD yang sangat signifikan pada tahun 2019 setelah sebelumnya mengalami penurunan pada tahun 2016-2018. Tujuan penelitian ini adalah untuk mengetahui gambaran distribusi spasiotemporal kejadian DBD di Kota Semarang. Jenis penelitian ini adalah deskriptif. Instrument meliputi peta lokasi, perangkat lunak GIS yaitu ArcGIS, dan perangkat lunak pengolah angka. Teknik pengambilan data melalui observasi data sekunder. Penelitian dilaksanakan bulan September 2020. Teknik analisa data menggunakan analisis univariat, analisis scatterplot, dan analisis spasial temporal. Hasil analisis spasiotemporal menunjukkan bahwa angka bebas jentik berkontribusi terhadap persebaran kejadian DBD di Kota Semarang tahun 2016 – 2019. Sedangkan variabel ketinggian wilayah dan kepadatan penduduk tidak berkontribusi.
Kata kunci: Analisis Spasial dan temporal; DBD; Kota Semarang
The Sunrise Model Approach to the Nutritional Status of Toddlers at the Kupang District Primary Health Center
Authors: Tat Florentianus , Romana Aben B.Y.H , Shafie Zainab Binti Mohd 
Published: January 2021

Nutritional problems in toddlers are still a major problem in East Nusa Tenggara Province. The 2018 Basic Health Research results show the percentage of malnourished babies aged 0-23 months in Indonesia was 3.8%, and malnutrition was 11.4%. East Nusa Tenggara is the province with the highest percentage of malnutrition among children aged 0-23 months in 2018. Nutritional problems have broad dimensions, such as socio-economic, cultural, educational, and environmental issues. The research objective is to determine the correlation between the sunrise model's factors and the toddler's nutritional status in the Kupang district. This study is a quantitative observational study with a cross-sectional design. The sampling technique in this study used accidental sampling. The research sample consisted of 169 people at 26 health centers. The results showed that there was a relationship between the use of health technology with the nutritional status of children under five (p=0.023), religious beliefs with family philosophy (p=0.024), family closeness (p=0.005), cultural and lifestyle factors (p=0.007), family economy (p=0.015), parental education (p=0.026), all variables have a significant relationship with the nutritional status of infants/toddlers (p=<0.05). It is concluded that there is a significant relationship between the factors in the sunrise model and the nutritional status of children under five in Kupang district. It is suggested that the sunrise model approach can be used to fix nutritional problems in children under five in Kupang Regency.
Shariah Governance Framework for IBIs: A Critical Analysis
Authors: Abbasi Abdul Sattar 
Published: January 2021

Purpose: The purpose of the article is to critically analyse State Bank of Pakistan’s Shariah governance framework (SGF) which is indeed a backbone for the survival of Islamic banking institutions (IBIs). Shariah compliance along with other contemporary standards makes it more challenging for the staff to ensure satisfaction of all stakeholders of IBIs. Besides profitability, IBI customers need complete satisfaction that their funds have been administered according to the Shariah law and returns are from permissible business operations.
Design/methodology/approach: SGF was analysed for making inferences by systematically and objectively identifying special characteristics of the framework for IBIs. Utilising interpretive and naturalistic approach including both observational and narrative based discourses associated with ground realities, the article outlines pragmatic modifications in existing framework to bridge the gap between Shariah boards and the board of directors.
Findings: Over the years Shariah governance mechanisms have significantly groomed in Pakistan, however, the need and room for improvement always remains for further developments . SGF enables convenient operations of IBIs with predetermined set of instructions and objectives. Nevertheless, IBIs need continuous monitoring and handholding to implement the SGF in true spirit. This article critically analysed updated SGF (2018) through content analysis and identified a few important gaps in the existing SGF. Those gapes such as absence of It has been observed that lack of performance evaluation of Board of Directors (BoD) and Shariah Board (SB) is important impediment in the development and expansion of IBIs.
Originality/Value: Current study identifies that existing SGF is devoid of determining key performance indicators (KPIs) for IBIs in terms of Shariah compliance and performance of BoDs and SBs. Therefore, this article concluded with proposed new Shariah governance framework for IBIs to ensure close liaison between BoD and SB through Board’s Committee of Shariah Governance (BCSG) with the provision of indicators for Shariah compliance ratings of IBIs.
Islamic Financing Portfolio and its Comparative Growth Potential
Authors: Arshed Noman , Yasmin Sadia , Gulzar Muhammad 
Published: January 2021

Background – Growth has a strong association with financial sector development. As both micro and macro projects significantly count institutionalized financing contented to the access of finance and help to reduce the cost. Islamic finance development incorporates several benefits such as the transformation of the economy towards the Shari’ah compliancy, higher degree of risk-sharing, and integration of returns with the risk/performance associated with the investment venture thus ultimately leading to social prosperity.
Objectives - This study envisages the exploration of the contribution of different type of Islamic banking financing which Islamic Banks are utilizing in their capital structure, on the economic growth. This assessment may help in empirically identifying the financing which has been fruitful to promote growth. This is because each of these Islamic financing products has their essence in the path of growth.
Design/methodology/approach - Gross Domestic Product (GDP) is taken as the dependent variable. And the Solow model based controlling variables includes Labor Resource (L), and Physical Capital (K) while the base variable are the financing modes. The quarterly data is collected for 9 countries which are available between 2014Q1 and 2017Q4.
Findings – The results indicate that other than Istisna financing, all other financings have a positive effect on economic growth, whereas Salam financing has highest growth potency.
Originality/value – Previous studies lack in providing a country-level comparison of growth effect of country-level Islamic capital structure. While, considering financing as an input of economic growth within a panel data setup. This study is finding growth based weights on the popular Islamic financing options, which policymakers can use to find a particular financing which needs promoting in order to boost economic growth.
The Impact of Learning Organization Practices on Subjective Performance of Employees: The Case of Islamic Financial Institutions (IFIs) of Developing Countries
Authors: Shah Muhammad Abdul Rehman , Meher Bano  , Shaherbano  
Published: January 2021

Purpose: The objective of this study is to explore the relationship between learning organization practices and subjective performance of employees moderated by employee engagement in in emerging financial markets of Malaysia, Pakistan, and Indonesia. There are identified continuous learning, collaboration and team learning, system to capture learning, empower employees, the connection to organization, strategic leadership, inquiry and dialogue as seven dimensions of learning organization practices. All of them affect more or less the subjective performance of employees in any organization.
Research Design: We select the sample of 230 people working in different departments of Islamic Financial Institutions (IFIs) of developing countries; Malaysia, Pakistan, and Indonesia. Data is collected from the concerned organizations.
Findings: On empirical basis, the relationship is found highly significant, learning organization is affecting subjective performance of employees with maximum coefficient of β=.681, which means an increase in learning organization practices will affect subjective performance of employees positively in emerging Islamic financial markets of Malaysia, Pakistan, and Indonesia.
Practical implications: The study recommends that learning organization practices should be considered to increase the subjective performance of the employees in IFIs of developing countries.
Originality/ value: An association between learning organization practices and subjective performance is explored with major concentration on conventional institutions of the developed countries, whereas this study explores the impact of learning organization practices on subjective performance of employees in the case of Islamic financial institutions (IFIs) of developing countries.