bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lower Extremity Burns, Complications, and Outcome
Authors: Momeni Mahnoush , Sediegh-Marufi Shahnam , Safari-Faramani Roya , Akhoondinasab Mohammad-Reza , Karimi Hamid , Karimi Ali-Mohammad 
Published: November 2019

Abstract
We have encountered many burn cases with lower extremity burn with adverse outcome. The study was a retrospective cohort study in 2 years, mean (SD) of follow up was 12(7) months. All demographic data, cause burn, time, total burn surface area (TBSA), presence lower extremity burn and its burn surface area (BSA), foot burn, delay in treatment, smoking, infection, morbidity, co-morbid diseases, length of stay (LOS), amputation, mortality, and outcome were gathered from patients’ files. Statistical analysis was done with SPSS 21software. We had 14,215 burn patients, of them 995 were admitted according to criteria of ABA. Six hundred and ten (61.3%) were male and 358 (37%) female. Male to female ratio was 1.58:1. The mean age ± SD was 33.64 ±23.45. Mean (SD) of lower extremity BSA was 12.09 ± 9.18%. The patients who had 10 to 19% burn, had 3 times more risk of mortality than patients with 0 to 9% burn (P &lt; .018). And those with 20 to 29% burn had 35 times more risk of mortality comparing to patients with 0 to 9% burn. The difference was significant too. (P &lt; .000). Delay in treatment, presence of co-morbid diseases and diabetes would not do any increase in mortality. The sex, weight, cause of burn, diabetes, and delay in treatment have not any influence on the death risk. But age and lower extremity BSA have influence on the risk of death. According to statistical study: with every 1-year increase in age, death rate increased by 4% (P &lt; .0001). With every 1% increase in lower extremity BSA, death rate increase by 9% (P &lt; .0005) and with every 1 day increase in LOS, the death rate increase by 4%. Statistical study shows lower extremity burn, TBSA, age, and LOS have great influence on the outcome of these patients. Sex, weight, cause of burn, and delay in treatment have not affected the risk of mortality.
A restricted second-order logic for non-deterministic poly-logarithmic time
Authors: Ferrarotti Flavio , GonzÁles SenÉn , Schewe Klaus-Dieter , Turull-Torres JosÉ MarÍa 
Published: November 2019

AbstractWe introduce a restricted second-order logic $\textrm{SO}^{\textit{plog}}$ for finite structures where second-order quantification ranges over relations of size at most poly-logarithmic in the size of the structure. We demonstrate the relevance of this logic and complexity class by several problems in database theory. We then prove a Fagin’s style theorem showing that the Boolean queries which can be expressed in the existential fragment of $\textrm{SO}^{\textit{plog}}$ correspond exactly to the class of decision problems that can be computed by a non-deterministic Turing machine with random access to the input in time $O((\log n)^k)$ for some $k \ge 0$, i.e. to the class of problems computable in non-deterministic poly-logarithmic time. It should be noted that unlike Fagin’s theorem which proves that the existential fragment of second-order logic captures NP over arbitrary finite structures, our result only holds over ordered finite structures, since $\textrm{SO}^{\textit{plog}}$ is too weak as to define a total order of the domain. Nevertheless, $\textrm{SO}^{\textit{plog}}$ provides natural levels of expressibility within poly-logarithmic space in a way which is closely related to how second-order logic provides natural levels of expressibility within polynomial space. Indeed, we show an exact correspondence between the quantifier prefix classes of $\textrm{SO}^{\textit{plog}}$ and the levels of the non-deterministic poly-logarithmic time hierarchy, analogous to the correspondence between the quantifier prefix classes of second-order logic and the polynomial-time hierarchy. Our work closely relates to the constant depth quasipolynomial size AND/OR circuits and corresponding restricted second-order logic defined by David A. Mix Barrington in 1992. We explore this relationship in detail.
Malassezia species dysbiosis in natural and allergen-induced atopic dermatitis in dogs
Authors: Meason-Smith Courtney , Olivry Thierry , Lawhon Sara D , Hoffmann Aline Rodrigues 
Published: November 2019

Abstract
Malassezia dermatitis and otitis are recurrent features of canine atopic dermatitis, increasing the cost of care, and contributing to a reduced quality of life for the pet. The exact pathogenesis of secondary yeast infections in allergic dogs remains unclear, but some have proposed an overgrowth of M. pachydermatis to be one of the flare factors. The distribution of Malassezia populations on healthy and allergic canine skin has not been previously investigated using culture-independent methods. Skin swabs were collected from healthy, naturally affected allergic, and experimentally sensitized atopic dogs. From the extracted DNA, fungal next-generations sequencing (NGS) targeting the ITS region with phylogenetic analysis of sequences for species level classification, and Malassezia species-specific quantitative real-time polymerase chain reaction (qPCR) were performed. M. globosa was significantly more abundant on healthy canine skin by both methods (NGS P &lt; .0001, qPCR P &lt; .0001). M. restricta was significantly more abundant on healthy skin by NGS (P = .0023), and M. pachydermatis was significantly more abundant on naturally-affected allergic skin by NGS (P &lt; .0001) and on allergen-induced atopic skin lesions by qPCR (P = .0015). Shifts in Malassezia populations were not observed in correlation with the development of allergen-induced skin lesions. Differences in the lipid dependency of predominant Malassezia commensals between groups suggests a role of the skin lipid content in driving community composition and raises questions of whether targeting skin lipids with therapeutics could promote healthy Malassezia populations on canine skin.
When galaxies align: intrinsic alignments of the progenitors of elliptical galaxies in the Horizon-AGN simulation
Authors: Bate James , Chisari Nora Elisa , Codis Sandrine , Martin Garreth , Dubois Yohan , Devriendt Julien , Pichon Christophe , Slyz Adrianne 
Published: November 2019

Abstract
Elliptical galaxies today appear aligned with the large-scale structure of the Universe, but it is still an open question when they acquire this alignment. Observational data is currently insufficient to provide constraints on the time evolution of intrinsic alignments, and hence existing models range from assuming that galaxies gain some primordial alignment at formation, to suggesting that they react instantaneously to tidal interactions with the large-scale structure. Using the cosmological hydrodynamical simulation Horizon-AGN, we measure the relative alignments between the major axes of galaxies and eigenvectors of the tidal field as a function of redshift. We focus on constraining the time evolution of the alignment of the main progenitors of massive z = 0 elliptical galaxies, the main weak lensing contaminant at low redshift. We show that this population, which at z = 0 has a stellar mass above 1010.4 M⊙, transitions from having no alignment with the tidal field at z = 3, to a significant alignment by z = 1. From z = 0.5 they preserve their alignment at an approximately constant level until z = 0. We find a mass-dependence of the alignment signal of elliptical progenitors, whereby ellipticals that are less massive today (1010.4 < M/M⊙ < 1010.7) do not become aligned till later redshifts (z < 2), compared to more massive counterparts. We also present an extended study of progenitor alignments in the parameter space of stellar mass and galaxy dynamics, the impact of shape definition and tidal field smoothing.
The ATLAS 9.0 GHz survey of the extended Chandra Deep Field South: the faint 9.0 GHz radio population
Authors: Huynh M T , Seymour N , Norris R P , Galvin T 
Published: November 2019

ABSTRACT
We present a new image of the 9.0 GHz radio emission from the extended Chandra Deep Field South. A total of 181 h of integration with the Australia Telescope Compact Array has resulted in a 0.276 deg2 image with a median sensitivity of ∼20 µJy beam−1 rms, for a synthesized beam of 4.0 × 1.3 arcsec. We present a catalogue of the 9.0 GHz radio sources, identifying 70 source components and 55 individual radio galaxies. Source counts derived from this sample are consistent with those reported in the literature. The observed source counts are also generally consistent with the source counts from simulations of the faint radio population. Using the wealth of multiwavelength data available for this region, we classify the faint 9 GHz population and find that 91 per cent are radio-loud active galactic nuclei (AGNs), 7 per cent are radio-quiet AGNs, and 2 per cent are star-forming galaxies. The 9.0 GHz radio sources were matched to 5.5 and 1.4 GHz sources in the literature and we find a significant fraction of flat or inverted spectrum sources, with 36 per cent of the 9 GHz sources having $\alpha _{5.5\,\mathrm{ GHz}}^{9.0\,\mathrm{ GHz}}$ &gt; −0.3 (for S ∝ να). This flat or inverted population is not well reproduced by current simulations of radio source populations.
Stability of exoplanetary systems retrieved from scalar time series
Authors: Kovács T 
Published: November 2019

Abstract
We propose a novel method applied to extrasolar planetary dynamics to describe the system stability. The observations in this field serve the measurements mainly of radial velocity, transit time, and/or celestial position. These scalar time series are used to build up the high-dimensional phase space trajectory representing the dynamical evolution of planetary motion. The framework of nonlinear time series analysis and Poincaré recurrences allows us to transform the obtained univariate signals into complex networks whose topology carries the dynamical properties of the underlying system. The network-based analysis is able to distinguish the regular and chaotic behaviour not only for synthetic inputs but also for noisy and irregularly sampled real world observations. The proposed scheme does not require neither n-body integration nor best fitting planetary model to perform the stability investigation, therefore, the computation time can be reduced drastically compared to those of the standard numerical methods.
Time-dependence of the astrophysical stochastic gravitational wave background
Authors: Mukherjee Suvodip , Silk Joseph 
Published: November 2019

Abstract
The astrophysical stochastic gravitational wave background (SGWB) is mostly produced from unresolved stellar binary mergers, and the number of events at any moment of time is expected to be Poisson-distributed. The event rate is governed by several astrophysical processes. The Poisson nature leads to variation in the number of sources and this causes temporal variations in the SGWB. The intrinsic temporal fluctuations of the SGWB are a rich source of astrophysical information that can be explored via ongoing and future gravitational wave experiments to classify the sources of the SGWB signal. Along with several other methods to estimate the GW event rates from individual sources, the study of the temporal variations of the SGWB signal provides an independent method for estimating the event rates of the GW sources that contribute to the SGWB. Along with direct estimates of event rates, this approach can also distinguish between different sources contributing to the SGWB signal and will be a useful probe of its evolution over a vast cosmic volume. On averaging over observation times, the SGWB will be statistically invariant under time translation. Statistical time translation symmetry of the SGWB is expected due to the negligible evolution of the relevant cosmological and astrophysical phenomena over the observation time-scales over which the data is collected.
Radiation-induced chemistry in the C2H2–H2O system at cryogenic temperatures: a matrix isolation study
Authors: Zasimov Pavel V , Ryazantsev Sergey V , Tyurin Daniil A , Feldman Vladimir I 
Published: November 2019

Abstract
Investigations of the low-temperature radiation-induced transformations in the C2H2–H2O system are relevant to the chemistry occurring in interstellar and cometary ices. In this work we applied a matrix isolation technique to study the radiation-driven evolution of this system at molecular level in order to get new mechanistic insight. The 1:1 C2H2∙∙∙H2O complexes were prepared in various solid noble-gas matrices (Ar, Kr, Xe) and these icy matrices were subjected to X-ray irradiation at 5 K. Decomposition of initial complex and formation of products were monitored by FTIR spectroscopy. It was found that complexation with H2O resulted in significant enhancement of the radiolytic decay of C2H2 molecules and provided new channels for its radiation-induced transformations. Ketene (both isolated H2CCO and in the form of H2CCO–H2 pair), ketenyl radical (HCCO), carbon monoxide (CO) and methane (CH4) were observed as main products of the C2H2∙∙∙H2O radiolysis. In addition, vinyl alcohol (CH2CHOH) was detected in an Ar matrix. The mechanistic interpretation (reaction routes leading to formation of these products) is discussed on the basis of consideration of kinetic dependencies and matrix effects. Conversion of C2H2∙∙∙H2O to CH4 is a prominent example of water-mediated cleavage of the C≡C triple bond, which may occur under prolonged irradiation in rigid media. Possible astrochemical implications of the obtained results are highlighted.
Morphological signatures induced by dust back reaction in discs with an embedded planet
Authors: Yang (楊朝欽) Chao-Chin , Zhu (朱照寰) Zhaohuan 
Published: November 2019

ABSTRACT
Recent observations have revealed a gallery of substructures in the dust component of nearby protoplanetary discs, including rings, gaps, spiral arms, and lopsided concentrations. One interpretation of these substructures is the existence of embedded planets. Not until recently, however, most of the modelling effort to interpret these observations ignored the dust back reaction to the gas. In this work, we conduct local-shearing-sheet simulations for an isothermal, inviscid, non-self-gravitating, razor-thin dusty disc with a planet on a fixed circular orbit. We systematically examine the parameter space spanned by planet mass (0.1Mth ≤ Mp ≤ 1Mth, where Mth is the thermal mass), dimensionless stopping time (10−3 ≤ τs ≤ 1), and solid abundance (0 &lt; Z ≤ 1). We find that when the dust particles are tightly coupled to the gas (τs &lt; 0.1), the spiral arms are less open and the gap driven by the planet becomes deeper with increasing Z, consistent with a reduced speed of sound in the approximation of a single dust–gas mixture. By contrast, when the dust particles are marginally coupled (0.1 ≲ τs ≲ 1), the spiral structure is insensitive to Z and the gap structure in the gas can become significantly skewed and unidentifiable. When the latter occurs, the pressure maximum radially outside of the planet is weakened or even extinguished, and hence dust filtration by a low-mass (Mp &lt; Mth) planet could be reduced or eliminated. Finally, we find that the gap edges where the dust particles are accumulated as well as the lopsided large-scale vortices driven by a massive planet, if any, are unstable, and they are broken into numerous small-scale dust–gas vortices.
The double-edged sword of cancer mutations: exploiting neoepitopes for the fight against cancer
Authors: Alvarado-Cruz Isabel , Meas Rithy , Paluri Sesha Lakshmi Arathi , Carufe Kelly Estelle Wheeler , Khan Mohammed , Sweasy Joann Balazs 
Published: November 2019

Abstract
Defects in DNA repair have been linked to the accumulation of somatic mutations in tumours. These mutations can promote oncogenesis; however, recent developments have indicated that they may also lead to a targeted immune response against the tumour. This response is initiated by the development of new antigenic epitopes (neoepitopes) arising from mutations in protein-coding genes that are processed and then presented on the surface of tumour cells. These neoepitopes are unique to the tumour, thus enabling lymphocytes to launch an immune response against the cancer cells. Immunotherapies, such as checkpoint inhibitors (CPIs) and tumour-derived vaccines, have been shown to enhance the immunogenic response to cancers and have led to complete remission in some cancer patients. There are tumours that are not responsive to immunotherapy or conventional tumour therapeutics; therefore, there is a push for new treatments to combat these unresponsive cancers. Recently, combinatorial treatments have been developed to further utilise the immune system in the fight against cancer. These treatments have the potential to exploit the defects in DNA repair by inducing more DNA damage and mutations. This can potentially lead to the expression of high levels of neoepitopes on the surface of tumour cells that will stimulate an immunological response. Overall, exploiting DNA repair defects in tumours may provide an edge in this long fight against cancer.
Design of a programmable biosensor-CRISPRi genetic circuits for dynamic and autonomous dual-control of metabolic flux in Bacillus subtilis
Authors: Wu Yaokang , Chen Taichi , Liu Yanfeng , Tian Rongzhen , Lv Xueqin , Li Jianghua , Du Guocheng , Chen Jian , Ledesma-Amaro Rodrigo , Liu Long 
Published: November 2019

Abstract
Dynamic regulation is an effective strategy for fine-tuning metabolic pathways in order to maximize target product synthesis. However, achieving dynamic and autonomous up- and down-regulation of the metabolic modules of interest simultaneously, still remains a great challenge. In this work, we created an autonomous dual-control (ADC) system, by combining CRISPRi-based NOT gates with novel biosensors of a key metabolite in the pathway of interest. By sensing the levels of the intermediate glucosamine-6-phosphate (GlcN6P) and self-adjusting the expression levels of the target genes accordingly with the GlcN6P biosensor and ADC system enabled feedback circuits, the metabolic flux towards the production of the high value nutraceutical N-acetylglucosamine (GlcNAc) could be balanced and optimized in Bacillus subtilis. As a result, the GlcNAc titer in a 15-l fed-batch bioreactor increased from 59.9 g/l to 97.1 g/l with acetoin production and 81.7 g/l to 131.6 g/l without acetoin production, indicating the robustness and stability of the synthetic circuits in a large bioreactor system. Remarkably, this self-regulatory methodology does not require any external level of control such as the use of inducer molecules or switching fermentation/environmental conditions. Moreover, the proposed programmable genetic circuits may be expanded to engineer other microbial cells and metabolic pathways.
High intrinsic hydrolytic activity of cyanobacterial RNA polymerase compensates for the absence of transcription proofreading factors
Authors: Riaz-Bradley Amber , James Katherine , Yuzenkova Yulia 
Published: November 2019

AbstractThe vast majority of organisms possess transcription elongation factors, the functionally similar bacterial Gre and eukaryotic/archaeal TFIIS/TFS. Their main cellular functions are to proofread errors of transcription and to restart elongation via stimulation of RNA hydrolysis by the active centre of RNA polymerase (RNAP). However, a number of taxons lack these factors, including one of the largest and most ubiquitous groups of bacteria, cyanobacteria. Using cyanobacterial RNAP as a model, we investigated alternative mechanisms for maintaining a high fidelity of transcription and for RNAP arrest prevention. We found that this RNAP has very high intrinsic proofreading activity, resulting in nearly as low a level of in vivo mistakes in RNA as Escherichia coli. Features of the cyanobacterial RNAP hydrolysis are reminiscent of the Gre-assisted reaction—the energetic barrier is similarly low, and the reaction involves water activation by a general base. This RNAP is resistant to ubiquitous and most regulatory pausing signals, decreasing the probability to go off-pathway and thus fall into arrest. We suggest that cyanobacterial RNAP has a specific Trigger Loop domain conformation, and isomerises easier into a hydrolytically proficient state, possibly aided by the RNA 3′-end. Cyanobacteria likely passed these features of transcription to their evolutionary descendants, chloroplasts.
Lack of Tularemia Among Health Care Providers With Close Contact With Infected Patients—A Case Series
Authors: Nelson Christina A , Brown Jennifer , Riley Linda , Dennis Anne , Oyer Ryan , Brown Catherine 
Published: November 2019

Abstract
Francisella tularensis has a low infectious dose and can infect laboratory staff handling clinical specimens. The risk to health care providers exposed during patient care is poorly defined. We describe 9 examples of health care providers who did not develop tularemia after significant exposures to infected patients.
The Living Spine Model: A Biomimetic Surgical Training and Education Tool
Authors: Bohl Michael A , McBryan Sarah , Pais Danielle , Chang Steve W , Turner Jay D , Nakaji Peter , Kakarla U Kumar 
Published: November 2019

Abstract

BACKGROUND
The Living Spine Model (LSM) is a three-dimensionally printed, surgical training platform developed by neurosurgical residents.

OBJECTIVE
To evaluate the face and content validity of this model as a training tool for open posterior lumbar surgery.

METHODS
Six surgeons with varying experience were asked to complete L3-5 pedicle screw fixation and L3-4 laminectomy on an LSM. Face validity was measured using a questionnaire, and content validity was measured using the National Aeronautics and Space Administration Task Load Index (NASA TLX) tests. Student's t-test was used to compare NASA TLX responses between junior and senior residents and to compare responses for live surgery vs simulated surgery on the LSM.

RESULTS
Junior residents took the longest time to complete the procedure, followed by senior residents and the attending surgeon (136.5, 98.3, and 84 min, respectively). The junior residents placed fewer successful pedicle screws (7/12) than senior residents and attending surgeon (18/18). All tested components of the model had excellent face validity, with scores ranging from 60% to 97%. Content validity testing demonstrated that the LSMs created overall workloads and specific types of work like live operating conditions.

CONCLUSION
The overall validity testing of the LSM demonstrates the high-potential utility of this model as a surgical education and testing platform for open posterior lumbar procedures. The LSM has great potential as an adjunct to surgical education, and it may become an increasingly important component of surgical resident curricula in the future.
Childhood vasculitis
Authors: Ozen Seza , Sag Erdal 
Published: November 2019

Abstract
Vasculitis is a challenging disease for paediatricians. Certain vasculitides are quite common in children whereas others are much rarer compared with adults. The most common vasculitides in childhood are IgA-associated vasculitis (Henoch–Schönlein purpura) and Kawasaki disease, which are usually self-limiting vasculitides although children do develop complications as a result. We now have much better knowledge of how to manage these patients and prevent the deleterious complications. This review provides an up-to-date discussion on childhood vasculitides, including diagnosis, treatment and follow-up strategies, together with a comparison with vasculitides in adults. It also discusses the newly defined monogenic vasculitides that often present during early childhood.