bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum neprilysin levels are associated with myocardial stunning after ST-elevation myocardial infarction
Authors: Legallois D , Macquaire C , Hodzic A , Allouche S , El Kouakhi I , Manrique A , Milliez P , Saloux E , Beygui F 
Published: November 2020

Abstract

Background/Introduction
Left ventricular remodeling following ST-elevation myocardial infarction (STEMI) is associated with poor outcome. Neprilysin inhibition leads to improved outcome in patients with altered left ventricular ejection fraction (LVEF).

Purpose
We aimed to assess the association between serum levels of neprilysin and left ventricular (LV) volumes, function and remodeling in STEMI patients with successful myocardial reperfusion.

Methods
Sixty-eight patients were admitted for STEMI and had both plasma neprilysin measurement at baseline and 3D transthoracic echocardiogram at baseline and at follow-up (7 months). We compared 3 groups: a group with a low-level of plasma neprilysin (&lt;125 pg/mL, i.e. the lower limit of detection of the assay, 38 patients) and the two other groups were defined as being below or above the median value of the remaining samples (15 patients each).

Results
Median age was 58.5±12.8 years and 56 (82.4%) were men. Median LVEF was 45.0±8.5%. Baseline characteristics were comparable among groups. At baseline there was a non-significant trend towards lower end-diastolic volume (p=0.07) but significantly lower LVEF in the high neprilysin group (46.4±8.3%, 47.1±8.1% and 39.1±6.9%, p&lt;0.01). At follow-up, the magnitude of LVEF increase was significantly more important in the high neprilysin group compared to the other groups (p=0.022 for relative change in LVEF and 6.6±7.3%, 3.6±9.0% and 11.3±8.4%, p=0.031 for absolute change in LVEF) resulting in similar LVEF levels at follow-up between all groups (53.0±8.9%, 50.6±9.7% and 50.4±9.9%, p=0.55).

Conclusion(s)
Initial high neprilysin levels may identify patients with stunned myocardium early after STEMI, with a recovery of contractility leading to improved LVEF at follow-up.

Funding Acknowledgement
Type of funding source: None
The association of acute-to-chronic glycemic ratio with no-reflow in ST elevation myocardial infarction patients undergoing primary percutaneous coronary intervention
Authors: Simsek B , Cinar T , Tanik V.O , Inan D , Zeren G , Avci I , Gungor B , Yilmaz F , Tanboga I.H , Karabay C.Y 
Published: November 2020

Abstract

Introduction
In the present study, we investigate the association of acute-to-chronic (A/C) glycemic ratio with no-reflow (NR) development in ST elevation myocardial infarction (STEMI) patients following primary percutaneous coronary intervention (PCI).

Material and methods
This retrospective study included 905 consecutive STEMI patients who were treated with primary PCI. The A/C glycemic ratio was determined as admission blood glucose (ABG) divided by the estimated average glucose (eAG). We evaluated two primary models (full model and reduced model).The primary outcome was the presence of NR.

Results
The incidence of NR was 22.7% (206 cases) in the present study. We divided the study population into three tertiles (T1, T2, and T3) based on the ABG/eAG ratio. There was a stepwise increase of the frequency of NR development from the T1 to T3 group (36 patients [12%] vs. 70 patients [23%] vs. 100 patients [33%]; respectively [p &lt;0.001, for each group comparison]). In a full model, the ABG/eAG ratio (OR; 2.274, 95% CI; 1.587–3.26, p&lt;0.001) was associated with NR. After the performance of a step-down backward variable selection method, the thrombus grade, the ABG/eAG ratio, the infarct-related artery diameter, and age remained in the reduced model. The ABG/eAG ratio (contributing 25.3% of the explainable outcome in the model) was one of the strong predictors of NR in the reduced model.

Conclusion
To the best of our knowledge, this might be the first study showing a significant relationship between the ABG/eAG ratios with NR in STEMI patients after primary PCI.
Figure 1

Funding Acknowledgement
Type of funding source: None
Compared prognostic impact of incident atrial fibrillation versus history of atrial fibrillation in patients with AMI: the FAST-MI programme
Authors: Danchin N , Fauchier L , Marijon E , Lavergne T , Boveda S , Martinet M , Defaye P , Piot O , Puymirat E , Bataille V , Drouet E , Ferrieres J , Schiele F , Simon T 
Published: November 2020

Abstract

Background
History of atrial fibrillation (HxAF) and new onset atrial fibrillation (NOAF) at acute stage of MI are associated with poorer survival. Whether both entities carry an increased risk of stroke is uncertain.
Using data from the FAST-MI 2010 and 2015 registries, we analysed the associations between HxAF and NOAF and risk of 3-year death, nonfatal stroke or combined death or stroke.

Methods
The FAST-MI registries are nationwide French cohorts consecutively including AMI patients admitted over a 1-month period every 5 years. Baseline characteristics, acute management and medications at discharge are collected. Among 9460 patients with STEMI or NSTEMI, 610 (6.4%) had HxAF, and 626 (6.6%) developed NOAF.

Main characteristics
Table 1 Overall, NOAF was associated with larger and more severe AMIs.

Results
In hospital survivors, 3-year death was 8.6% in patients without AF, 23.2% in those with NOAF and 29.2% in those with HxAF. 3-year Kaplan-Meier rates of non-fatal stroke were 1.1%, 0.3% and 3.6%, respectively (Figure).
Compared with no AF, NOAF was not associated with non-fatal stroke (Cox HR, 95% CI: 0.17, 0.02–1.21), while HxAF was (HR, 95% CI 2.04, 1.13–3.66, P=0.017). Risk of death or stroke was increased for both NOAF (HR, 95% CI 1.35, 1.10–1.65, P=0.004) and HxAF (HR 95% CI, 1.37, 1.14–1.65, P=0.001). Risk of all-cause death at 3 years was increased for NOAF (HR, 95% CI 1.32, 1.09–1.60) and HxAF (HR, 95% CI 1.30, 1.09–1.55). The results were concordant in patients not receiving oral anticoagulants at discharge.

Conclusion
Both NOAF and HxAF are associated with increased risk of death at 3 years after AMI. NOAF, however, is not associated with an increased risk of non-fatal stroke.
Figure 1. Non-fatal stroke

Funding Acknowledgement
Type of funding source: Other. Main funding source(s): Pharma companies
Long-term predictors of myocardial infarction recurrence in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention
Authors: Silverio A , De Angelis E , Cancro F.P , Di Maio M , Esposito L , Romei S , Citro R , Ciccarelli M , Vecchione C , Galasso G 
Published: November 2020

Abstract

Background
Despite the implementation in the use of primary percutaneous coronary intervention (pPCI) and in secondary preventive measures, the risk of recurrence of myocardial infarction (MI) in patients who underwent ST-elevation myocardial infarction (STEMI) remains high. The prognostic role of old and emerging cardiovascular risk factors for MI recurrence, such as Lipoprotein(a) [Lp(a)] levels, in this very high-risk population is still not fully understood.

Purpose
To identify the baseline predictors of MI recurrence in a cohort of patients admitted for STEMI and treated with pPCI.

Methods
Single-center, observational, retrospective analysis of consecutive patients admitted for STEMI who underwent pPCI from February 2013 to April 2019 at our Insitution. Baseline demographic, clinical, echocardiographic and laboratory data were prospectively collected. Only patients with available Lp(a) values were included in the analysis.
The study outcome was the recurrence of MI at three years follow-up. Univariable and multivariable Cox regression analysis was performed to identify the baseline variables correlated to the study outcome.

Results
The study population included 560 patients (mean age = 60.6±13.7 years; 79.5% males). Hypertension was observed in 351 patients (62.7%), diabetes in 134 (23.9%), dyslipidemia in 266 (47.5%), smoking status in 316 (56.4%), history of coronary artery disease (CAD) in 76 (13.6%), prior MI in 69 (12.3%), prior PCI in 62 (11.1%). Multivessel disease (MVD) was reported in 211 (37.7%) cases. The infarct-related artery was the left anterior descending in 310 patients (55.4%), the right coronary artery in 179 (32.0%), the left circumflex 60 (10.7%) and the left main in 11 (2.0%). Total cholesterol mean value was 187.7±48.8 mg/dl; LDL cholesterol was 112.2±41.3 mg/dl and Lp(a) was 26.5±27.2 mg/dl. At three-year follow-up, MI occurred in 58 (10.4%) patients. At multivariable analysis, Lp(a) (HR 1.015 95% CI: 1.008–1.022 p&lt;0.001) and MVD (HR 1.994; 95% CI 1.179–3.372 p=0.010) emerged as the only two independent predictors of MI recurrence up to three years. The Kaplan-Meier analysis showed a significantly lower survival free from MI in patients with Lp(a) ≥50 mg/dl as compared to the subgroups with levels ≥30 and &lt;50 mg/dL, or &lt;30 mg/dL (Log-Rank=0.001). Also, MVD was able to identify patients with significantly lower survival free from MI for up to three years (Log-Rank=0.004). The Kaplan-Meier analysis combining these two parameters identified patients with both MVD and Lp(a) ≥50 mg/dl as the highest risk cohort for MI recurrence up to three years (MI incidence rate=22.2%; Log-Rank=0.002).

Conclusions
Among patients with STEMI who underwent pPCI, high Lp(a) level and MVD predict the recurrence of MI at long-term follow-up.

Funding Acknowledgement
Type of funding source: None
Predictive factors of a prolonged total ischemic time in patients presenting with ST-segment elevation myocardial infarction
Authors: Lopez Lluva M.T , Jurado Roman A , Lozano Ruiz Poveda F , Abellan Huertas J , Frias Garcia R , Sanchez Perez I 
Published: November 2020

Abstract

Introduction
Total ischemic time (TIT), the time from symptom onset to therapeutic reperfusion of infarcted myocardium is a key factor in the treatment of patients with ST-segment elevation myocardial infarction (STEMI). The identification of the predictive factors of a prolonged TIT will allow design specific strategies to optimize this time and improve the quality of care of these patients. Our objective was to evaluate independent factors predicting prolonged TIT.

Methods
We performed a prospective observational study, with consecutive inclusion of all patients presenting within 24 hours of symptom onset of STEMI (n=546), transferred to our center for primary percutaneous coronary intervention (pPCI).

Results
The median TIT was 190 (137–281) minutes. No significant differences were found according to the year of study. In the univariate analysis, age showed a slight trend (p=0.05); for each year that is increased, the TTI increases 1.3 minutes. Women had higher TII than men [219 (145–332) vs. 187 (133–270) minutes; p=0.02]. No statistically significant differences were found in relation to the presence of cardiovascular risk factors. Patients treated during non-working hours had shorter TIT than those treated during working hours [179 (130–252) vs. 202 (142–307) minutes; p=0.03]. The distance to a 24h-PCI hospital was an independent predictive factor. Those patients whose first medical contact (FMC) was in a non-PCI-capable hospital or in a clinic showed the highest TIT [226 (147–336) and 205 (146–304) minutes, respectively; p&lt;0.001]. Patients with initial non-diagnostic ECG presented a significantly longer TIT (p&lt;0.001) than patients correctly diagnosed since the beginning, with a median difference of 188 minutes. A trend was observed for the Killip-Kimball classification variable (p=0.07). Patients with previous infarction had shorter TIT compared to those who have never had it (p=0.02). In the multivariate binary logistic regression analysis, the variables: initial non-diagnostic ECG, FMC (in a non-PCI-capable hospital or clinic) and the distance to 24h-PCI hospital (&gt;90 km) were independent predictive factors of a TIT &gt;180 minutes. An initial non-diagnostic or misinterpreted ECG sextuples the risk of a prolonged TIT.

Conclusions
In our area, the total ischemic time is determined by a non-diagnostic or misinterpreted EKG, the first medical contact and the distance to a 24h-PCI hospital.

Funding Acknowledgement
Type of funding source: None
Clinical outcome of patients with ST-elevation myocardial infarction and angiographic evidence of coronary artery ectasia
Authors: Silverio A , Esposito L , Fierro G , Di Maio M , Di Feo F , Iannicelli A , Varone M , Vigorito F , Maione A , Di Muro M.R , Attisano T , Vecchione C , Galasso G , Baldi C 
Published: November 2020

Abstract

Background
Coronary artery ectasia (CAE) is a relatively frequent finding in patient with ST-elevation myocardial infarction (STEMI) who undergo emergent coronary angiography. However, the long-term outcome of STEMI patients with CAE as compared to Non-CAE has been poorly investigated.

Purpose
To compare the baseline features and outcome of patients with and without CAE in the clinical setting of STEMI.

Methods
All patients with STEMI who underwent emergent coronary angiography from January 2012 to December 2017 at our Institution were retrospectively enrolled. Baseline demographic, clinical, instrumental, angiographic and percutaneous coronary intervention (PCI) findings were collected for patients with and without CAE. The study outcome measures were recurrent myocardial infarction (MI) and all-cause death. The propensity score weighting (PSW) technique was used to take into account for potential selection bias in treatment assignment between CAE and Non-CAE groups.

Results
The study included 534 patients with STEMI (mean age 62.9±12.0 years), 154 were CAE and 380 Non-CAE. The two groups were significantly different in terms of sex (90.9% in CAE vs 72,6% in Non-CAE, p&lt;0.001), diabetes (11.7% vs. 25.8%; p=0.009) and smoking status (72.1% vs. 62.4%; p=0.042). The right coronary artery was more commonly treated in CAE patients (41.6% vs. 30.8%, p=0.023) and, as expected, the stent diameter (p&lt;0.001) and the TIMI frame count (p&lt;0.001) were significantly higher in CAE group. The myocardial blush grade was higher in Non-CAE (p&lt;0.001). The Kaplan-Meyer analysis showed a comparable rate of all-cause death among the two groups (3.4/100 person/years in CAE vs. 3.5 per 100 person/years in Non-CAE, Log-Rank = 0.86).
The survival free from recurrent MI was lower, although not statistically significant, in CAE vs. Non-CAE patients (3.1/100 person/years vs. 4.8/100 person/years; Log-Rank = 0.068).
After PSW, an optimal balance was obtained as demonstrated by a standardized mean difference &lt;0.1 for all the variables included in the model. The adjusted Cox regression analysis showed a significantly higher risk of recurrent MI in CAE vs. Non-CAE groups (HR = 1.93; p=0.009). No difference in the risk of all-cause death was observed (HR = 0.83, p=0.501).

Conclusions
Patient with STEMI and angiographic evidence of CAE have a different clinical profile compared to Non-CAE. In this analysis focused on STEMI patients, CAE was associated with a higher risk of recurrent MI at long-term follow-up.

Funding Acknowledgement
Type of funding source: None
Global longitudinal strain and chronic kidney disease prognostic impact on acute coronary syndrome
Authors: Morgado Gomes A.R , Campos D , Saleiro C , Gameiro Lopes J , Sousa J.P , Puga L , Antonio N , Goncalves L 
Published: November 2020

Abstract

Background
Impaired left ventricular ejection fraction (LVEF) and chronic kidney disease (CKD) have been associated with poorer outcomes in acute coronary syndrome (ACS). Increasing evidence on global left ventricular longitudinal strain (GLS) suggests superiority over left ventricular ejection fraction (LVEF) in risk stratification.

Methods
This study was based on a retrospective analysis of consecutive patients admitted to a Coronary Care Unit between 2009 and 2016. Baseline characteristics and echocardiographic parameters, including LVEF, were assessed. For each patient, a two-dimensional speckle tracking of the left ventricle was assessed and average GLS was calculated using 2, 3 and 4-chamber views. Blood creatinine was measured during hospital stay and used to estimate glomerular filtration rate (GFR) with Modification of Diet in Renal Disease (MDRD) equation. A cox regression analysis was performed to determine mortality prediction value of average GLS, LVEF and GFR in this population. Receiver operating characteristic (ROC) curve analysis was conducted and area under the curve (AUC) was estimated.

Results
A total of 85 patients (66.7±12.7 years old; 78.8% males) were enrolled. LVEF mean was 49.4±9.8% and average GLS was −16.0±4.0%. GFR median was 80.0±48.9 ml/min/1.73m2. In cox regression analysis, worse average GLS was associated with greater mortality (HR 0.721; 95% CI 0.599–0.867; P=0.001). GFR was inversely related to death (HR 0.967; 95% CI 0.944–0.991, P=0.008). In cox regression analysis using average GLS and GFR as covariates, both proved to be independent predictors of mortality (for average GLS, HR 0.748; 95% CI 0.610–0.918, P=0.005; for GFR, HR 0.974; 95% CI 0.949–0.999; P=0.044). The AUC of average GLS to predict mortality was 0.78 (P&lt;0.001, sensitivity 50.7% and specificity 100%) and for average GLS and GFR combined was 0.85 (P&lt;0.001, sensitivity 84.0% and specificity 77.8%). Although LVEF proved to be a mortality predictor, the AUC obtained by ROC curve analysis was inferior to average GLS, with statistical significance (P=0.043).

Conclusions
GLS and CKD proved to be independent predictors of mortality in ACS patients. GLS showed superiority when compared to LVEF in risk stratification and in the future it might replace LVEF. The model combining GLS and GFR emphasized the increased risk of CKD patients and how they should be seen as high-risk patients.
ROC curve analysis

Funding Acknowledgement
Type of funding source: None
Gender differences in acute coronary syndrome: experience from the Croatian branch of the ISACS-CT registry
Authors: Loncaric F , Mjehovic P , Sabljak D , Vlahovic V , Vinkovic I , Radic T , Klaric K , Dakic A , Adamovic I , Bunic M , Pavasovic S , Jakus N , Fabijanovic D , Cikes M , Milicic D 
Published: November 2020

Abstract

Background and aim
In recent years, worse outcomes of female acute coronary syndrome (ACS) patients have been recognized. The aim was to explore gender differences in ACS in the Croatian branch of the ISACS-CT registry (NCT01218776).

Methods
From January 2012 to May 2018, 3066 ACS patients were enrolled; 50% (n=1539) presenting with STEMI, 35% (n=1071) with NSTEMI, and 15% (n=456) with unstable angina (UA). In-hospital mortality was defined as the primary endpoint.

Results
At admission women were older, more burdened with comorbidities, with a longer delay from symptom onset to admission (Figure 1), but without differences in signs and symptoms or Troponin T levels (p=0.166). During hospitalization, there were no gender difference in the administration of beta blockers, ACE inhibitors or statins in the first 24 hours. Coronary angiography was performed in a smaller percentage of female patients (86 vs. 92%, p&lt;0.001), however, the finding of no significant stenosis was more common in women (6 vs. 2%, p&lt;0.001). Furthermore, less women underwent primary PCI (pPCI) (67 vs. 77%, p&lt;0.001). While there were no gender differences in the number of the treated lesions (p=0.978), women had a higher incidence of procedural pPCI complications compared to men (13 vs. 8%, p=0.001) – predominantly due to higher occurrence of no reflow, side branch loss and new thrombus formation. Multivariate regression showed gender was not associated with the decision not to perform pPCI, whereas age over 65 years (OR=1.75), diabetes (OR=1.30), hypertension (OR=1.55), chronic kidney disease (OR=2.06) and the delay from onset of symptoms to admission &gt;6h (OR=1.61) were associated. At discharge, there were no gender differences in LV ejection fraction &lt;40% (p=0.259). Women with STEMI had significantly higher in-hospital mortality (10 vs. 4%, p&lt;0.001), whereas no gender differences were seen regarding unstable angina and NSTEMI. After multivariate regression, only age over 65 years (OR=3.61), chronic kidney disease (OR=1.85) and primary PCI (OR=0.49) remained associated with in-hospital mortality.

Conclusion
The findings in the Croatian branch of the ISACS-CT registry demonstrate notable gender differences in ACS. Older age and a substantial burden of comorbidities represent strong influences on disease development, intervention choice and in-hospital mortality when treating women with ACS.
Figure 1

Funding Acknowledgement
Type of funding source: None
The association of smoking to cardiovascular death differs according to age and sex following myocardial infarction complicated by heart failure or left ventricular dysfunction
Authors: Hall T.S , Orn S , Zannad F , Rossignol P , Duarte K , Solomon S , Atar D , Agewall S , Dickstein K , Girerd N 
Published: November 2020

Abstract

Background
Smoking is associated with higher morbidity and mortality following myocardial infarction (MI), but reports of the impact on cardiovascular (CV) death in aged and female patients experiencing MI complicated with left ventricular dysfunction or overt heart failure are limited.

Methods
In an individual patient data meta-analysis of high-risk MI patients, the association of smoking to CV death was investigated. Cox proportional hazard models exploring smoking status and risk according to age and sex were performed to study the relationship of smoking to independently adjudicated CV death endpoints.

Results
28,771 patients from the CAPRICORN, EPHESUS, OPTIMAAL and VALIANT trials were assessed. 18,325 (64%) reported smoking (9185 (32%) current and 9051 (32%) past), 2662 (9%) were above ≥80 years and 8607 (30%) were women. Overall, using non-smokers as referent, the association of smoking to CV mortality was neutral (HR=1.07, 0.98 to 1.16, p=0.12 for active smoking and HR=1.10, 1.02 to 1.18, p=0.01 for past smoking). The associations for active and past smokers with outcome, adjusted for age and sex in the overall study sample and according to different age and sex categories, are presented in figure 1. In analyses that included interaction terms, the association for active smokers depended on age and sex; the risk of CV mortality was weakened in women (interaction HR=0.81, 0.69 to 0.96, p=0.01) and older age (interaction HR per 10 years increase=0.88, 0,82 to 0.95, p=0.001). In contrast, the association to CV death for past smokers was not modified by sex or age (p=0.86 and p=0.17 respectively).

Conclusions
The association of smoking to CV death differed according to age and sex in MI complicated with left ventricular dysfunction or overt heart failure. Significant association of active and/or past smoking with increased risk of CV death was mainly observed in the 60–69 years category. The underlying reasons of the lack of association of smoking with outcome in older patients in this specific context should be explored further in future studies.
Figure 1

Funding Acknowledgement
Type of funding source: None