bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘It’s kinda bad, honestly’: Australian students’ experiences of relationships and sexuality education
Authors: Waling Andrea , Bellamy Roz , Ezer Paulina , Kerr Lucille , Lucke Jayne , Fisher Christopher 
Published: August 2020

Abstract
Relationships and sexuality education for young people in Australia and elsewhere is a controversial topic. Numerous studies in Australia have focused on curriculum, policy, teachers, schools, sexting and other behaviours, and knowledge regarding sexually transmitted infection (STI)/human immunodeficiency virus (HIV) and pregnancy prevention. Few large-scale national studies have engaged with young people about what they want out of their sex education, and what they suggest would be most valuable for future programs in Australia. Data for the study included qualitative comments about experiences of sex education (n = 2316) provided in a national survey of adolescent sexual health. An initial thematic inductive analysis identified comments falling into two dominant themes: positive and negative experiences of their sex education. Results indicate that young people in Australia are articulate and understanding of the gaps in their sex education. A majority of comments highlighted negative experiences. These comments primarily discussed issues of delivery (timing, environment, person) and content quality (comprehensiveness). A minority highlighted positive commentary also around delivery (environment, person) and content quality (comprehensiveness). The findings of this study illuminate contemporary adolescent concerns regarding their experiences of education. Understanding these experiences can inform future curriculum development, teacher training and the design and implementation of policy.
Quantifying the performance of selective devices by combining analysis of catch data and fish behaviour observations: methodology and case study on a flatfish excluder
Authors: Santos Juan , Herrmann Bent , Stepputtis Daniel , Kraak Sarah B M , Gökçe Gökhan , Mieske Bernd 
Published: August 2020

AbstractThis article describes a method for the quantitative analysis of fish behaviour relative to selection devices in trawl gears. Based on video observations, the method estimates probabilities for a given event to happen and establishes behavioural tree diagrams representing and quantifying behavioural patterns in relation to the selection device under assessment. Double bootstrapping is used to account for the uncertainty originating from a limited number of fish observations and the natural variation in fish behaviour. The method is used here to supplement standard analysis of catch data for the performance assessment of a flatfish excluder (FLEX). The Baltic Sea trawl fishery targeting cod (Gadus morhua) provides the pilot case. Results obtained by comparing catches with and without FLEX installed revealed that &gt;75% of bycaught flatfish individuals escaped through the device, while no evidence was found that catches of cod in the targeted sizes were reduced. The behavioural analysis produced values of escape efficiency comparable to those obtained in the catch analysis. Furthermore, it revealed that ∼80% of the flatfish went calmly into the excluder, while most of the roundfish displayed avoidance swimming reactions. The method provides quantitative information of fish behaviour that can be relevant for developing and optimizing selection devices.
Effective Density for Inhomogeneous Quadratic Forms I: Generic Forms and Fixed Shifts
Authors: Ghosh Anish , Kelmer Dubi , Yu Shucheng 
Published: August 2020

Abstract
We establish effective versions of Oppenheim’s conjecture for generic inhomogeneous quadratic forms. We prove such results for fixed shift vectors and generic quadratic forms. When the shift is rational we prove a counting result, which implies the optimal density for values of generic inhomogeneous forms. We also obtain a similar density result for fixed irrational shifts satisfying an explicit Diophantine condition. The main technical tool is a formula for the 2nd moment of Siegel transforms on certain congruence quotients of $SL_n(\mathbb{R}),$ which we believe to be of independent interest. In a sequel, we use different techniques to treat the companion problem concerning generic shifts and fixed quadratic forms.
Amylin, Aβ42, and Amyloid in Varicella Zoster Virus Vasculopathy Cerebrospinal Fluid and Infected Vascular Cells
Authors: Bubak Andrew N , Beseler Cheryl , Como Christina N , Coughlan Christina M , Johnson Noah R , Hassell James E , Burnet Anna M , Mescher Teresa , Schmid D Scott , Coleman Colin , Mahalingam Ravi , Cohrs Randall J , Boyd Timothy D , Potter Huntington , Shilleh Ali H , Russ Holger A , Nagel Maria A 
Published: August 2020

Abstract

Background
Varicella zoster virus (VZV) vasculopathy is characterized by persistent arterial inflammation leading to stroke. Studies show that VZV induces amyloid formation that may aggravate vasculitis. Thus, we determined if VZV central nervous system infection produces amyloid.

Methods
Aβ peptides, amylin, and amyloid were measured in cerebrospinal fluid (CSF) from 16 VZV vasculopathy subjects and 36 stroke controls. To determine if infection induced amyloid deposition, mock- and VZV-infected quiescent primary human perineurial cells (qHPNCs), present in vasculature, were analyzed for intracellular amyloidogenic transcripts/proteins and amyloid. Supernatants were assayed for amyloidogenic peptides and ability to induce amyloid formation. To determine amylin’s function during infection, amylin was knocked down with small interfering RNA and viral complementary DNA (cDNA) was quantitated.

Results
Compared to controls, VZV vasculopathy CSF had increased amyloid that positively correlated with amylin and anti-VZV antibody levels; Aβ40 was reduced and Aβ42 unchanged. Intracellular amylin, Aβ42, and amyloid were seen only in VZV-infected qHPNCs. VZV-infected supernatant formed amyloid fibrils following addition of amyloidogenic peptides. Amylin knockdown decreased viral cDNA.

Conclusions
VZV infection increased levels of amyloidogenic peptides and amyloid in CSF and qHPNCs, indicating that VZV-induced amyloid deposition may contribute to persistent arterial inflammation in VZV vasculopathy. In addition, we identified a novel proviral function of amylin.
Benchmarking Human Performance in Semi-Automated Image Segmentation
Authors: Eramian Mark , Power Christopher , Rau Stephen , Khandelwal Pulkit 
Published: August 2020

AbstractSemi-automated segmentation algorithms hold promise for improving extraction and identification of objects in images such as tumors in medical images of human tissue, counting plants or flowers for crop yield prediction or other tasks where object numbers and appearance vary from image to image. By blending markup from human annotators to algorithmic classifiers, the accuracy and reproducability of image segmentation can be raised to very high levels. At least, that is the promise of this approach, but the reality is less than clear. In this paper, we review the state-of-the-art in semi-automated image segmentation performance assessment and demonstrate it to be lacking the level of experimental rigour needed to ensure that claims about algorithm accuracy and reproducability can be considered valid. We follow this review with two experiments that vary the type of markup that annotators make on images, either points or strokes, in tightly controlled experimental conditions in order to investigate the effect that this one particular source of variation has on the accuracy of these types of systems. In both experiments, we found that accuracy substantially increases when participants use a stroke-based interaction. In light of these results, the validity of claims about algorithm performance are brought into sharp focus, and we reflect on the need for a far more control on variables for benchmarking the impact of annotators and their context on these types of systems.
Underrepresented racial minorities in biomedical informatics doctoral programs: graduation trends and academic placement (2002–2017)
Authors: Wiley Kevin , Dixon Brian E , Grannis Shaun J , Menachemi Nir 
Published: August 2020

Abstract

Objective
Biomedical informatics attracts few underrepresented racial minorities (URMs) into PhD programs. We examine graduation trends from 2002 to 2017 to determine how URM representation has changed over time. We also examine academic job placements by race and identify individual and institutional characteristics associated with URM graduates being successfully placed in academic jobs.

Materials and Methods
We analyze a near census of all research doctoral graduates from US-accredited institutions, surveyed at graduation by the National Science Foundation Survey of Earned Doctorates. Graduates of biomedical informatics-related programs were identified using self-reported primary and secondary disciplines. Data are analyzed using bivariate and multivariable logistic regressions.

Results
During the study period, 2426 individuals earned doctoral degrees in biomedical informatics-related disciplines. URM students comprised nearly 12% of graduates, and this proportion did not change over time (2002–2017). URMs included Hispanic (5.7%), Black (3.2%), and others, including multi-racial and indigenous American populations (2.8%). Overall, 82.3% of all graduates accepted academic positions at the time of graduation with significantly more Hispanic graduates electing to go into academia (89.2%; P &lt; .001). URM graduates were more likely to be single (OR = 1.38; P &lt; .05), have a dependent (1.95; P &lt; .01), and not receive full tuition remission (OR = 1.37; P = .05) as a student. URM graduates accepting an academic position were less likely to be a graduate of a private institution (OR = 0.70; P &lt; .05).

Discussion and Conclusion
The proportion of URM candidates among biomedical informatics doctoral graduates has not increased over time and remains low. In order to improve URM recruitment and retention within academia, leaders in biomedical informatics should replicate strategies used to improve URM graduation rates in other fields.
Range-Wide Population Structure of 3 Deepwater Eteline Snappers Across the Indo-Pacific Basin
Authors: Andrews Kimberly R , Copus Joshua M , Wilcox Christie , Williams Ashley J , Newman Stephen J , Wakefield Corey B , Bowen Brian W 
Published: August 2020

AbstractDeep-sea habitats may drive unique dispersal and demographic patterns for fishes, but population genetic analyses to address these questions have rarely been conducted for fishes in these environments. This study investigates the population structure of 3 tropical deepwater snappers of the genus Etelis that reside at 100–400 m depth, with broad and overlapping distributions in the Indo-Pacific. Previous studies showed little population structure within the Hawaiian Archipelago for 2 of these species: Etelis coruscans and E. carbunculus. Here we extend sampling to the entire geographic range of each species to resolve the population genetic architecture for these 2 species, as well as a recently exposed cryptic species (Etelis sp.). One goal was to determine whether deepwater snappers are more dispersive than shallow-water fishes. A second goal was to determine whether submesophotic fishes have older, more stable populations than shallow reef denizens that are subject to glacial sea-level fluctuations. Both goals are pertinent to the management of these valuable food fishes. A total of 1153 specimens of E. coruscans from 15 geographic regions were analyzed, along with 1064 specimens of E. carbunculus from 11 regions, and 590 specimens of E. sp. from 16 regions. The first 2 species were analyzed with mtDNA and 9–11 microsatellite loci, while E. sp. was analyzed with mtDNA only. Etelis coruscans had a non-significant microsatellite global FST, but significant global mtDNA Ф ST = 0.010 (P = 0.0007), with the isolation of Seychelles in the western Indian Ocean, and intermittent signals of isolation for the Hawaiian Archipelago. Etelis carbunculus had a non-significant microsatellite global FST, and significant global mtDNA Ф ST = 0.021 (P = 0.0001), with low but significant levels of isolation for Hawaiʻi, and divergence between Tonga and Fiji. Etelis sp. had mtDNA Ф ST = 0.018 (P = 0.0005), with a strong pattern of isolation for both Seychelles and Tonga. Overall, we observed low population structure, shallow mtDNA coalescence (similar to near-shore species), and isolation at the fringes of the Indo-Pacific basin in Hawaiʻi and the western Indian Ocean. While most shallow-water species have population structure on the scale of biogeographic provinces, deepwater snapper populations are structured on the wider scale of ocean basins, more similar to pelagic fishes than to shallow-water species. This population structure indicates the capacity for widespread dispersal throughout the Indo-Pacific region.
The First Record of Aedes vittatus (Diptera: Culicidae) in the Dominican Republic: Public Health Implications of a Potential Invasive Mosquito Species in the Americas
Authors: Alarcón-Elbal P M , Rodríguez-Sosa M A , Newman B C , Sutton W B 
Published: August 2020

Abstract
Aedes vittatus Bigot is distributed throughout Africa, tropical Asia, and southern Europe and occurs in sylvatic as well as peridomestic environments where it readily feeds on humans. Although the vectorial capacity of Ae. vittatus is not well understood, this species is known to play a role in the maintenance and transmission of yellow fever, Zika, chikungunya, and dengue virus within its native range. In October 2019, after a routine inspection of mosquito-breeding containers in Jarabacoa, Dominican Republic, two Ae. vittatus females were captured via human landing catch method. After this finding, a CDC miniature light trap was deployed at the point of initial detection from 18:00 to 08:00 h, 2 d/wk from 3 to 31 October 2019. Potential larval habitats were also sampled via traditional dip method once per week spanning a 150 m radius from point of initial detection. In addition to the 2 adult females, 10 female and 2 male Ae. vittatus were captured. One Ae. vittatus larva also was found in a small puddle formed by an animal hoof print. Conventional PCR and Sanger sequencing were used to confirm morphological identification of collected specimens. This is the first detection of Ae. vittatus in the Dominican Republic as well as the Americas. Therefore, enhanced surveillance is needed to better understand the range and public health risks this potential invasive mosquito species may pose in the Dominican Republic, other Caribbean Islands, and/or the Americas.
Long-Term Neurocognitive and Psychosocial Outcomes After Acute Myeloid Leukemia: A Childhood Cancer Survivor Study Report
Authors: Stefanski Kristen J , Anixt Julia S , Goodman Pamela , Bowers Katherine , Leisenring Wendy , Scott Baker K , Burns Karen , Howell Rebecca , Davies Stella , Robison Leslie L , Armstrong Gregory T , Krull Kevin R , Recklitis Christopher 
Published: August 2020

AbstractBackgroundSurvivors of childhood acute myeloid leukemia (AML) are vulnerable to medical late effects of treatment; however, less is known about their psychosocial outcomes. This study evaluated neurocognitive and psychosocial outcomes in long-term AML survivors treated with bone marrow transplantation (BMT) or intensive chemotherapy (IC) without BMT.MethodsAML survivors (N = 482; median age at diagnosis = 8 [range = 0-20] years; median age at evaluation = 30 [range = 18-49] years) treated with BMT (n = 183) or IC (n = 299) and sibling controls (N = 3190; median age at evaluation = 32 [range = 18-58] years) from the Childhood Cancer Survivor Study were compared on emotional distress (Brief Symptom Inventory-18), neurocognitive problems (Childhood Cancer Survivor Study Neurocognitive Questionnaire), health-related quality of life (SF-36), and social attainment. Outcomes were dichotomized (impaired vs nonimpaired) using established criteria, and relative risks (RRs) were estimated with multivariable Poisson regression, adjusted for age at evaluation and sex.ResultsAML survivors were more likely than siblings to report impairment in overall emotional (RR = 2.19, 95% confidence interval [CI] = 1.51 to 3.18), neurocognitive (RR = 2.03, 95% CI = 1.47 to 2.79), and physical quality of life (RR = 2.71, 95% CI = 1.61 to 4.56) outcomes. Survivors were at increased risk for lower education (RR = 1.15, 95% CI = 1.03 to 1.30), unemployment (RR = 1.41, 95% CI = 1.16 to 1.71), lower income (RR = 1.39, 95% CI = 1.17 to 1.65), and not being married or having a partner (RR = 1.33, 95% CI = 1.17 to 1.51). BMT-treated survivors did not differ statistically significantly from IC-treated on any outcome measure.ConclusionsAML survivors are at increased risk for psychosocial impairment compared with siblings; however, BMT does not confer additional risk for psychosocial late effects compared with treatment without BMT.
The Association of Veterans’ PSA Screening Rates With Changes in USPSTF Recommendations
Authors: Becker Daniel J , Rude Temitope , Walter Dawn , Wang Chan , Loeb Stacy , Li Huilin , Ciprut Shannon , Kelly Matthew , Zeliadt Steven B , Fagerlin Angela , Lepor Herbert , Sherman Scott , Ravenell Joseph E , Makarov Danil V 
Published: August 2020

Abstract

Background
In 2012, the United States Preventative Services Task Force (USPSTF) formally recommended against all prostate-specific antigen (PSA) screening for prostate cancer. Our goal was to characterize PSA screening trends in the Veterans Health Administration (VA) before and after the USPSTF recommendation and to determine if PSA screening was more likely to be ordered based on a veteran’s race or age.

Methods
Using the VA Corporate Data Warehouse, we created 10 annual groups of PSA-eligible men covering 2009-2018. We identified all PSA tests performed in the VA to determine yearly rates of PSA screening. All statistical tests were 2-sided.

Results
The overall rate of PSA testing in the VA decreased from 63.3% in 2009 to 51.2% in 2018 (P &lt; .001). PSA screening rates varied markedly by age group during our study period, with men aged 70-80 years having the highest initial rate and greatest decline (70.6% in 2009 to 48.4% in 2018, P &lt; .001). Men aged 55-69 years had a smaller decline (65.2% in 2009 to 58.9% in 2018, P &lt; .001) whereas the youngest men, aged 40-54 years, had an increase in PSA screening (26.2% in 2009 to 37.8% in 2018, P &lt; .001).

Conclusions
In this analysis of PSA screening rates among veterans before and after the 2012 USPSTF recommendation against screening, we found that overall PSA screening decreased only modestly, continuing for more than one-half of the men in our study. Veterans of different races had similar screening rates, suggesting that VA care may minimize racial disparities. Veterans of varying ages experienced statistically significantly differences in PSA screening trends.
Monocytic Acute Myeloid Leukemias with KM2TA Translocations to Chromosome 17q that May Clinically Mimic Acute Promyelocytic Leukemia
Authors: Balbuena-Merle Raisa I , Tormey Christopher A , DiAdamo Autumn , Rinder Henry M , Siddon Alexa J 
Published: August 2020

Abstract

Objective
Acute promyelocytic leukemia (APL) with variant RARA translocation, eg, t(11;17), is not sensitive to all-trans retinoic acid and requires distinct chemotherapy. However, there are some leukemic entities that may mimic aspects of the clinical and/or laboratory picture of APL and cause confusion because of karyotype nomenclature. Therefore, recognition of such entities may be of therapeutic and prognostic significance.

Methods
We present 2 cases of acute myeloid leukemia (AML) with t(11;17) that were clinically concerning for APL based primarily on clinical presentation but were ultimately diagnosed as AML with monocytic differentiation.

Results
Both leukemias harbored KMT2A translocations, one located near but not involving RARA and the other with SEPT9.

Conclusion
In leukemias that clinically and/or immunophenotypically mimic APL, identification of specific gene translocations can lead to the correct diagnosis and may carry therapeutic/prognostic implications.
Prospective observational study of respiratory Aspergillus colonization or disease in patients with various stages of chronic obstructive pulmonary disease utilizing culture versus nonculture techniques
Authors: Waqas Sarmad , Dunne Katie , Talento Alida Fe , Wilson Graham , Martin-Loeches Ignacio , Keane Joseph , Rogers Thomas R 
Published: August 2020

Abstract
Chronic obstructive pulmonary disease (COPD) patients have been recognized to be at increased risk of Aspergillus spp. colonization, which may progress to invasive pulmonary aspergillosis (IPA). The objective of this study was to determine the frequency of Aspergillus colonization, or disease, in a cohort of COPD patients. A prospective observational study was undertaken to determine Aspergillus colonization, or disease, in consecutive COPD patients undergoing bronchoscopy. Fungal culture as well as galactomannan antigen (GM) and Aspergillus nucleic acid detection (PCR) were performed on bronchoalveolar lavage fluid (BAL) samples. One hundred and fifty patients were recruited. One hundred and twelve (74.7%) were outpatients, 38 (25.33%) were inpatients, of whom 6 (4%) were in the intensive care unit. Most patients (N = 122, 81.3%) were either COPD GOLD (Global Initiative for Chronic Obstructive Lung Disease) stages 1 or 2. Nine (6%) patients were on systemic steroids, 64 (42.7%) on inhaled steroids, and 9 (6%) on both. Seventeen patients (11.3%) had at least one positive test for Aspergillus detection (culture ± galactomannan ± polymerase chain reaction [PCR]), 13 (76.4%) of whom were COPD GOLD stages 1 or 2. Five patients had probable or putative IPA. Aspergillus sp. was detected in five patients (3.3%) by culture, but detection increased to 17 (11.3%) by the additional testing for GM or Aspergillus DNA. The frequency of Aspergillus detection in this cohort of COPD patients may reflect the predominance of early GOLD stages among the study population but deserves further investigation to determine its relevance as a predictive risk factor for IPA.
MEGARA-IFU detection of extended He ii λ4686 nebular emission in the central region of NGC 1569 and its ionization budget
Authors: Mayya Y D , Carrasco E , Gómez-González V M A , Zaragoza-Cardiel J , Gil de Paz A , Ovando P A , Sánchez-Cruces M , Lomelí-Núñez L , Rodríguez-Merino L , Rosa-González D , Silich S , Tenorio-Tagle G , Bruzual G , Charlot S , Terlevich R , Terlevich E , Vega O , Gallego J , Iglesias-Páramo J , Castillo-Morales A , García-Vargas M L , Gómez-Alvarez P , Pascual S , Pérez-Calpena A 
Published: August 2020

ABSTRACTWe here report the detection of extended He ii λ4686 nebular emission in the central region of NGC 1569 using the integral field spectrograph MEGARA at the 10.4 m Gran Telescopio Canarias. The observations cover a field of view (FoV) of 12.5 arcsec × 11.3 arcsec at a seeing-limited spatial resolution of ∼15 pc and at a spectral resolution of R = 6000 in the wavelength range 4330–5200 Å. The emission extends over a semicircular arc of ∼40 pc width and ∼150 pc diameter around the superstar cluster A (SSC-A). The AV derived using Balmer decrement varies from the Galactic value of 1.6 mag to a maximum of ∼4.5 mag, with a mean value of 2.65 ± 0.60 mag. We infer 124 ± 11 Wolf–Rayet (WR) stars in SSC-A using the He ii λ4686 broad feature and AV = 2.3 mag. The He+ ionizing photon rate from these WR stars is sufficient to explain the luminosity of the He ii nebula. The observationally determined total He+ and H0 ionizing photon rates, their ratio, and the observed number of WR stars in SSC-A are all consistent with the predictions of simple stellar population models at an age of 4.0 ± 0.5 Myr and a mass of (5.5 ± 0.5) × 105 M⊙. Our observations reinforce the absence of WR stars in SSC-B, the second most massive cluster in the FoV. None of the other locations in our FoV where He ii λ4686 emission has been reported from narrow-band imaging observations contain WR stars.