bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anticoagulation clinic drive-up service during COVID-19 pandemic in Qatar
Authors: Alhmoud Eman , Abdelsamad Osama , Soaly Ezeldin , Enany Rasha El , Elewa Hazem 
Published: July 2020

AbstractCoronavirus Disease 2019 (COVID-19) is a pandemic affecting many countries worldwide. Given the increasing incidence especially in elderly and individuals with comorbid conditions, it is advised by health authorities to stay home if possible, maintain social distancing and stay away from those who are sick or could be infected. Patients with comorbidities especially cardiovascular disease are at higher risk of getting infected with COVID-19 and have worse prognosis. Among efforts to safely manage warfarin patients during this pandemic, we introduced a hospital drive-up anticoagulation testing service. This service can reduce the risk of exposure of anticoagulation patients to COVID-19 by reducing the contact time with the different personnel at the hospital and by maintaining those patients at a safe distance from others
The use of doxazosin before adrenalectomy for pheochromocytoma: is the duration related to intraoperative hemodynamics and postoperative complications?
Authors: Kong Hao , Li Nan , Tian Jie , Bao Zhengqing , Liu Lu , Wu Kai , Gao Ying , Jin Bo , Zhang Zheng , Fang Dong , Zhang Junqing , Zhou Liqun 
Published: July 2020

Abstract
Purpose
No conclusion exists for the optimum duration of preoperative administration of doxazosin (DOX) before adrenalectomy for pheochromocytoma. The purpose of this study is to investigate whether perioperative hemodynamics and postoperative outcomes are related to the duration of DOX administration.

Methods
In total, 132 patients managed preoperatively with single α-receptor blocker DOX were enrolled. All patients underwent adrenalectomy for pheochromocytoma in the Department of Urology, Peking University First Hospital, between January 2001 and July 2019. Patients were divided into three groups based on the duration of preoperative administration of DOX: group A (≤14 days), group B (15–30 days), and group C (>30 days). Patient and tumor characteristics, intraoperative hemodynamics, and postoperative outcomes were recorded and compared.

Results
These patients included 57 men and 75 women, with an average age of 48 years. Clinical characteristics, preoperative hemodynamics, medicine management and surgical approaches were comparable between the three groups. Among the three groups, we found that group C (>30 days) had the lowest intraoperative minimum heart rate [group A vs. group B vs. group C = 60 (52–67) vs. 59 (50–61) vs. 51.5 (50–58.75), p = 0.024] and highest risk of postoperative hypotension requiring vasopressor support [group A vs. group B vs. group C = 14 (20.3%) vs. 12 (27.9%) vs. 10 (50.0%), p = 0.032].

Conclusion
The current study indicated that preoperative management of pheochromocytoma with single α-receptor blocker DOX for more than 30 days after final dose adjustment might lead to intraoperative bradycardia and more postoperative hypotension requiring vasopressor support. Thus, our study does not support long-term (over 30 days) preoperative administration of pheochromocytoma with single α-receptor blocker DOX in the final dose.
Biological activity of mistletoe: in vitro and in vivo studies and mechanisms of action
Authors: Szurpnicka Anna , Kowalczuk Anna , Szterk Arkadiusz 
Published: July 2020

AbstractMistletoe has been used as treatment of many diseases in traditional and folk medicine. To date, anticancer, immunomodulatory, cardiac, antidiabetic, hepatoprotective, neuropharmacological, antibacterial and antifungal properties of mistletoe extracts have been studied the most. In this review, we summarized in vitro and in vivo studies on the pharmacological activity of Viscum species. Furthermore, we proposed the possible mechanisms of action of this herb, which might include many signalling pathways. Mistletoe could regulate either similar or different targets in various pathways that act on membrane receptors, enzymes, ion channels, transporter proteins and transcriptional targets. Still, pharmacological activities of mistletoe have been investigated mainly for crude extracts. It is a new field for scientists to determined which chemical compounds are responsible for the individual biological activities of mistletoe and how these activities are achieved. As a result, mistletoe might become a source of new complementary therapies supporting the treatment of many diseases.
A Critical Analysis of Methodology Pitfalls in Duplex Doppler Ultrasound in the Evaluation of Patients with Erectile Dysfunction: Technical and Interpretation Deficiencies
Authors: Nascimento Bruno , Miranda Eduardo P. , Terrier Jean-Etienne , Carneiro Felipe , Mulhall John P. 
Published: July 2020

Abstract

Background
Penile duplex Doppler ultrasound (PDDU) is a minimally invasive tool to evaluate erectile hemodynamics in patients with erectile dysfunction (ED). Despite decades of use, there is still a large variability in PDDU protocols, and a high rate of false diagnosis is reported.

Aim
Review of PDDU methodology in the published literature addressing protocol heterogeneity, technical and interpretation challenges.

Methods
A PubMed literature search was performed using the search terms “penile doppler ultrasound”, “penile duplex ultrasound” or “penile ultrasound”, and “Erectile dysfunction”. Studies were analyzed for the presence of the following elements in reporting of the PDDU protocol: (i) intracavernosal vasoactive agents used, (ii) use of a redosing protocol, (iii) means of rigidity assessment, (iv) report of at-home best-quality erection, (v) normative criteria for peak systolic velocity (PSV) and end-diastolic velocity (EDV), and (vi) use of time-based hemodynamics assessment. Inclusion criteria were studies available in English, from 2005 onwards, and with full text. Exclusion criteria were review, descriptive or short communication articles, animal studies, and studies in populations other than those with ED.

Outcomes
A critical review of the heterogeneity in published literature was performed to guide a structured discussion of methodological challenges and to create a list of recommendations.

Results
Significant heterogeneity was seen in key methodological aspects. Fifty percent of studies reported the use of prostaglandin E1 only, and 12% of studies did not mention the agent used. Redosing as part of the PDDU protocol was mentioned in only 26% of studies. The majority (56%) did not mention any form of rigidity assessment. The most frequently used grading system was the Erection Hardness Score (14%). Overall, most studies (59%) used a timed-base protocol for hemodynamic assessment. No clear consensus was defined for normative criteria for PSV and EDV, 39% defining a normal PSV as ≥30 cm/s, and 57% using EDV values ≤5 cm/sec as normal.

Clinical Implications
The absence of standardization has led to inadequate reporting of key factors which has rendered data interpretation and comparison between studies challenging.

Strengths and Limitations
Our strengths include an extensive review of literature, with a structured analysis of the impact of each methodological pitfall. Our main limitation is the fact that protocol reporting, and not its application, was assessed.

Conclusion
Despite its widespread use, analysis of the literature on PDDU use in the ED population shows marked protocol heterogeneity, rendering data interpretation a problem.
Modelling performance an air transport network operated by subsonic and supersonic aircraft
Authors: Janić M. 
Published: July 2020

ABSTRACTThis paper deals with modelling the performance of an air transport network operated by existing subsonic and the prospective supersonic commercial aircraft. Analytical models of indicators of the infrastructural, technical/technological, operational, economic, environmental, and social performance of the network relevant for the main actors/stakeholders involved are developed. The models are applied to the given long-haul air route network exclusively operated by subsonic and supersonic aircraft according to the specified “what-if” scenarios.The results from application of the models indicate that supersonic flights powered by LH2 (Liquid Hydrogen) could be more feasible than their subsonic counterparts powered by Jet A fuel, in terms of about three times higher technical productivity, 46% smaller size of the required fleet given the frequency of a single flight per day, 20% lower sum of the aircraft/airline operational, air passenger time, and considered external costs, up to two times higher overall social-economic feasibility, and 94% greater savings in contribution to global warming and climate change. These flights could be less feasible in terms of about 70-85% higher aircraft/airline operational costs, 70% and 19% higher fuel consumption and emissions of Green House Gases, respectively, and 6-13% higher noise compared to the specified acceptable levels.
Joint Effects of Ownership and Competition on the Relationship between Innovation and Productivity: Application of the CDM Model to the Chinese Manufacturing Sector
Authors: Shi Junguo , Sadowski Bert , Li Sihan , Nomaler Önder 
Published: July 2020

ABSTRACTOn the basis of a rich panel data set of large- and medium-sized Chinese manufacturing enterprises, we observe that different types of firms (i.e., state-owned enterprises [SOEs], foreign-funded ownership [FFO] of firms, Hong Kong-Macau-Taiwanese [HMT] companies and privately-owned firms) exploit different stages of the innovation – productivity chain depending on the extent of market concentration. By applying a modified CDM model, this study reveals that SOEs tend to be more active in making innovative decisions and pursuing innovative investments but are less efficient in terms of innovation output and labour productivity, whereas FFO firms have relatively high labour productivity but are less active in the first three stages of the innovation – productivity chain. Market competition favours SOEs in the production of additional innovation products. Foreign firms are efficient in labour productivity if they are operating in a concentrated market. By using the metaphor of DNA, this study explains the heterogeneity among these different forms of ownership and generates several managerial implications.
GRAPHS DETERMINED BY THEIR -GAIN SPECTRA
Authors: WANG SAI , WONG DEIN , TIAN FENGLEI 
Published: July 2020

AbstractAn undirected graph $G$ is determined by its $T$-gain spectrum (DTS) if every $T$-gain graph cospectral to $G$ is switching equivalent to $G$. We show that the complete graph $K_{n}$ and the graph $K_{n}-e$ obtained by deleting an edge from $K_{n}$ are DTS, the star $K_{1,n}$ is DTS if and only if $n\leq 2$, and an odd path $P_{2m+1}$ is not DTS if $m\geq 2$. We give an operation for constructing cospectral $T$-gain graphs and apply it to show that a tree of arbitrary order (at least $5$) is not DTS.
NOTE ON MINIMUM DEGREE AND PROPER CONNECTION NUMBER
Authors: WU YUEYU , ZHANG YUNQING , CHEN YAOJUN 
Published: July 2020

AbstractAn edge-coloured graph $G$ is called properly connected if any two vertices are connected by a properly coloured path. The proper connection number, $pc(G)$, of a graph $G$, is the smallest number of colours that are needed to colour $G$ such that it is properly connected. Let $\unicode[STIX]{x1D6FF}(n)$ denote the minimum value such that $pc(G)=2$ for any 2-connected incomplete graph $G$ of order $n$ with minimum degree at least $\unicode[STIX]{x1D6FF}(n)$. Brause et al. [‘Minimum degree conditions for the proper connection number of graphs’, Graphs Combin.33 (2017), 833–843] showed that $\unicode[STIX]{x1D6FF}(n)>n/42$. In this note, we show that $\unicode[STIX]{x1D6FF}(n)>n/36$.
REGULATING GENOME EDITING UNDER INTERNATIONAL HUMAN RIGHTS LAW
Authors: Yotova Rumiana 
Published: July 2020

AbstractThis article offers a critical assessment of the role of international human rights law in the regulation of genome editing. Given the rapid scientific developments in the field of genetics, it is important to explore the implications of the human rights framework for the research into and the clinical application of genome editing. The broader normative question is whether the existing human rights standards are sufficient to address the challenges posed by this new technology. It will be argued that while international human rights law does not prohibit genome editing, it imposes important restrictions upon it. However, existing human rights are arguably insufficient to regulate germline genome editing as there are significant loopholes in the protection of embryos. Nor do they fully address the wide-ranging implications of the new technology for society and humankind. It will be suggested that new standards are needed, ideally set out in a new international instrument and supported by an institutional framework, which address the specific challenges posed by this new technology.
MARITIME AUTONOMOUS VEHICLES: NEW FRONTIERS IN THE LAW OF THE SEA
Authors: Klein Natalie , Guilfoyle Douglas , Karim Md Saiful , McLaughlin Rob 
Published: July 2020

AbstractThe ongoing development of diverse maritime autonomous vehicles for varied ocean activities—ranging from scientific research, security surveillance, transportation of goods, military purposes and commission of crimes—is prompting greater consideration of how existing legal frameworks accommodate these vehicles. This article brings together the core legal issues, as well as current developments in relation to commercial shipping, the law of naval warfare, and maritime security. This article captures how these issues are now being addressed and what other legal questions will likely emerge as the newest technology impacts on one of the oldest bodies of international law.
Management of fetal ductus arteriosus constriction with Digoxin and oxygen therapy
Authors: Naqvi Alina Z. , Lanni Susan M. , Rosenthal Joanna B. 
Published: July 2020

AbstractConstriction of the fetal ductus arteriosus is rare and usually attributed to medications or CHD. We describe a 24-year-old multigravida at 33 weeks 5 days gestation with echocardiographic findings of severe ductal constriction, a dilated, hypertrophied and hypocontractile right ventricle, and severe tricuspid regurgitation following BC powder® use. Treatment with Digoxin and oxygen resulted in a progressive 71% reduction in peak systolic ductal gradient, improved right ventricular function, and decreased tricuspid regurgitation.
Associations of dietary diversity with anaemia and iron status among 5- to 12-year-old schoolchildren in South Africa
Authors: Visser Marina , Van Zyl Tertia , Hanekom Susanna M , Baumgartner Jeannine , van der Hoeven Marinka , Taljaard-Krugell Christine , Smuts Cornelius M , Faber Mieke 
Published: July 2020

AbstractObjective:To examine the associations of dietary diversity with anaemia and iron status among primary school-aged children in South Africa.Design:An analysis was conducted with pooled individual data from the baseline surveys from three previously conducted independent intervention studies. Two different dietary diversity scores (DDS) were calculated based on data from 1-day (1-d) and 3-day (3-d) dietary recall periods, respectively. Logistic regression analysis was performed to examine the associations of dietary diversity with anaemia and iron status.Setting:KwaZulu-Natal and North West provinces, South Africa.Participants:Children (n 578) 5- to 12-year-old.Results:A DDS ≤ 4 was associated with higher odds of being anaemic (1-d P = 0·001; 3-d P = 0·006) and being iron deficient (ID) (3-d P < 0·001). For both recall periods, consumption of ‘vegetables and fruits other than vitamin A-rich’ and ‘animal-source foods (ASF)’ was associated with lower odds of being anaemic (both P = 0·002), and ‘organ meats’ with lower odds of being ID (1-d P = 0·045; 3-d P < 0·001). Consumption of ‘meat, chicken and fish’ was associated with lower odds of being anaemic (P = 0·045), and ‘vegetables and fruits other than vitamin A-rich’, ‘legumes, nuts and seeds’ and ‘ASF’ with lower odds of being ID for the 3-d recall period only (P = 0·038, P = 0·020 and P = 0·003, respectively).Conclusion:In order to improve anaemia and iron status among primary school-aged children, dietary diversification, with emphasis on consumption of vegetables, fruits and ASF (including organ meats), should be promoted.
Ambient weathering of magnesium oxide for CO2 removal from air
Authors: McQueen Noah , Kelemen Peter , Dipple Greg , Renforth Phil , Wilcox Jennifer 
Published: July 2020

AbstractTo avoid dangerous climate change, new technologies must remove billions of tonnes of CO2 from the atmosphere every year by mid-century. Here we detail a land-based enhanced weathering cycle utilizing magnesite (MgCO3) feedstock to repeatedly capture CO2 from the atmosphere. In this process, MgCO3 is calcined, producing caustic magnesia (MgO) and high-purity CO2. This MgO is spread over land to carbonate for a year by reacting with atmospheric CO2. The carbonate minerals are then recollected and re-calcined. The reproduced MgO is spread over land to carbonate again. We show this process could cost approximately $46–159 tCO2−1 net removed from the atmosphere, considering grid and solar electricity without post-processing costs. This technology may achieve lower costs than projections for more extensively engineered Direct Air Capture methods. It has the scalable potential to remove at least 2–3 GtCO2 year−1, and may make a meaningful contribution to mitigating climate change.
Rationally inattentive intertemporal choice
Authors: Gershman Samuel J. , Bhui Rahul 
Published: July 2020

AbstractDiscounting of future rewards is traditionally interpreted as evidence for an intrinsic preference in favor of sooner rewards. However, temporal discounting can also arise from internal uncertainty in value representations of future events, if one assumes that noisy mental simulations of the future are rationally combined with prior beliefs. Here, we further develop this idea by considering how simulation noise may be adaptively modulated by task demands, based on principles of rational inattention. We show how the optimal allocation of mental effort can give rise to the magnitude effect in intertemporal choice. In a re-analysis of two prior data sets, and in another experiment, we reveal several behavioral signatures of this theoretical account, tying choice stochasticity to the magnitude effect. We conclude that some aspects of temporal discounting may result from a cognitively plausible adaptive response to the costs of information processing.
Reconciling contrasting views on economic complexity
Authors: Sciarra Carla , Chiarotti Guido , Ridolfi Luca , Laio Francesco 
Published: July 2020

AbstractSummarising the complexity of a country’s economy in a single number is the holy grail for scholars engaging in data-based economics. In a field where the Gross Domestic Product remains the preferred indicator for many, economic complexity measures, aiming at uncovering the productive knowledge of countries, have been stirring the pot in the past few years. The commonly used methodologies to measure economic complexity produce contrasting results, undermining their acceptance and applications. Here we show that these methodologies – apparently conflicting on fundamental aspects – can be reconciled by adopting a neat mathematical perspective based on linear-algebra tools within a bipartite-networks framework. The obtained results shed new light on the potential of economic complexity to trace and forecast countries’ innovation potential and to interpret the temporal dynamics of economic growth, possibly paving the way to a micro-foundation of the field.
Anomalous 3D nanoscale photoconduction in hybrid perovskite semiconductors revealed by tomographic atomic force microscopy
Authors: Song Jingfeng , Zhou Yuanyuan , Padture Nitin P. , Huey Bryan D. 
Published: July 2020

AbstractWhile grain boundaries (GBs) in conventional inorganic semiconductors are frequently considered as detrimental for photogenerated carrier transport, their exact role remains obscure for the emerging hybrid perovskite semiconductors. A primary challenge for GB-property investigations is that experimentally they need to be performed at the top surface, which is not only insensitive to depth-dependent inhomogeneities but also could be susceptible to topographic artifacts. Accordingly, we have developed a unique approach based on tomographic atomic force microscopy, achieving a fully-3D, photogenerated carrier transport map at the nanoscale in hybrid perovskites. This reveals GBs serving as highly interconnected conducting channels for carrier transport. We have further discovered the coexistence of two GB types in hybrid perovskites, one exhibiting enhanced carrier mobilities, while the other is insipid. Our approach reveals otherwise inaccessible buried features and previously unresolved conduction pathways, crucial for optimizing hybrid perovskites for various optoelectronic applications including solar cells and photodetectors.
Sub-single exciton optical gain threshold in colloidal semiconductor quantum wells with gradient alloy shelling
Authors: Taghipour Nima , Delikanli Savas , Shendre Sushant , Sak Mustafa , Li Mingjie , Isik Furkan , Tanriover Ibrahim , Guzelturk Burak , Sum Tze Chien , Demir Hilmi Volkan 
Published: July 2020

AbstractColloidal semiconductor quantum wells have emerged as a promising material platform for use in solution-processable lasers. However, applications relying on their optical gain suffer from nonradiative Auger decay due to multi-excitonic nature of light amplification in II-VI semiconductor nanocrystals. Here, we show sub-single exciton level of optical gain threshold in specially engineered CdSe/CdS@CdZnS core/crown@gradient-alloyed shell quantum wells. This sub-single exciton ensemble-averaged gain threshold of (Ng)≈ 0.84 (per particle) resulting from impeded Auger recombination, along with a large absorption cross-section of quantum wells, enables us to observe the amplified spontaneous emission starting at an ultralow pump fluence of ~ 800 nJ cm−2, at least three-folds better than previously reported values among all colloidal nanocrystals. Finally, using these gradient shelled quantum wells, we demonstrate a vertical cavity surface-emitting laser operating at a low lasing threshold of 7.5 μJ cm−2. These results represent a significant step towards the realization of solution-processable electrically-driven colloidal lasers.
A thermally activated and highly miscible dopant for n-type organic thermoelectrics
Authors: Yang Chi-Yuan , Ding Yi-Fan , Huang Dazhen , Wang Jue , Yao Ze-Fan , Huang Chun-Xi , Lu Yang , Un Hio-Ieng , Zhuang Fang-Dong , Dou Jin-Hu , Di Chong-an , Zhu Daoben , Wang Jie-Yu , Lei Ting , Pei Jian 
Published: July 2020

AbstractN-doping plays an irreplaceable role in controlling the electron concentration of organic semiconductors thus to improve performance of organic semiconductor devices. However, compared with many mature p-doping methods, n-doping of organic semiconductor is still of challenges. In particular, dopant stability/processability, counterion-semiconductor immiscibility and doping induced microstructure non-uniformity have restricted the application of n-doping in high-performance devices. Here, we report a computer-assisted screening approach to rationally design of a triaminomethane-type dopant, which exhibit extremely high stability and strong hydride donating property due to its thermally activated doping mechanism. This triaminomethane derivative shows excellent counterion-semiconductor miscibility (counter cations stay with the polymer side chains), high doping efficiency and uniformity. By using triaminomethane, we realize a record n-type conductivity of up to 21 S cm−1 and power factors as high as 51 μW m−1 K−2 even in films with thicknesses over 10 μm, and we demonstrate the first reported all-polymer thermoelectric generator.