bluuebunny/crossref_metadata_2025_split huggingface dataset:
North Atlantic Circulation Regimes and Heat Transport by Synoptic Eddies
Authors: Ruggieri Paolo , Alvarez-Castro M. Carmen , Athanasiadis Panos , Bellucci Alessio , Materia Stefano , Gualdi Silvio 
Published: February 2020

AbstractMeridional transport of heat by transient atmospheric eddies is a key component of the energy budget of the middle- and high-latitude regions. The heat flux at relevant frequencies is also part of a dynamical interaction between eddies and mean flow. In this study we investigate how the poleward heat flux by high-frequency atmospheric transient eddies is modulated by North Atlantic weather regimes in reanalysis data. Circulation regimes are estimated via a clustering method, a jet-latitude index, and a blocking index. Heat transport is defined as advection of moist static energy. The focus of the analysis is on synoptic frequencies but results for slightly longer time scales are reported. Results show that the synoptic eddy heat flux is substantially modulated by midlatitude weather regimes on a regional scale in midlatitude and polar regions. In a zonal-mean sense, the phases of the North Atlantic Oscillation do not significantly change the high-latitude synoptic heat flux, whereas Scandinavian blocking and the Atlantic ridge are associated with an intensification. A close relationship between high-latitude (midlatitude) heat flux and Atlantic jet speed (latitude) is found. The relationship between extreme events of synoptic heat flux and circulation regimes is also assessed and reveals contrasting behaviors in the polar regions. The perspective that emerges complements the traditional view of the interaction between synoptic eddies and the extratropical flow and reveals relationships with the high-latitude climate.
Summer Water Vapor Sources in Northeast Asia and East Siberia Revealed by a Moisture-Tracing Atmospheric Model
Authors: Piao Jinling , Chen Wen , Chen Shangfeng , Gong Hainan , Zhang Qiong 
Published: February 2020

AbstractPrevious studies found a seesaw pattern of summer precipitation between northeast Asia and east Siberia on an interannual time scale, which is associated with an eastward-propagating atmospheric wave train over Eurasia and corresponding water vapor transport circulations. Using a general circulation model with an embedded water-tagging module, the main water vapor sources of the two regions, as well as the relative contributions of each source region to the total precipitation for both the climatological mean and interdecadal variation, are further compared in this study. The model simulation results show that local evaporation, the Pacific Ocean, and East Asia are the dominant moisture sources for northeast Asian precipitation. In contrast, for east Siberia, moisture mainly originates from the Pacific Ocean, northeast Asia, west Siberia, and local evaporation. This suggests that the local evaporation and Pacific Ocean are both crucial to the moisture supply of the two regions, implying the important roles of the land processes and adjacent oceanic sources. In addition, northeast Asia appears to be the major moisture source for east Siberia, whereas east Siberia has weak impacts on the moisture input for northeast Asia. Further analysis finds that the model simulation can capture interdecadal changes in summer precipitation over the two regions around the late 1990s. This interdecadal change is mainly manifested in the moisture supplies from the Pacific Ocean, North Atlantic Ocean, and east Siberia, which suggests a link with the circulation anomalies under the combined impacts of the Pacific decadal oscillation and the Atlantic multidecadal oscillation.
Restratification at a California Current Upwelling Front. Part II: Dynamics
Authors: Johnson Leah , Lee Craig M. , D’Asaro Eric A. , Wenegrat Jacob O. , Thomas Leif N. 
Published: February 2020

AbstractA coordinated multiplatform campaign collected detailed measurements of a restratifying surface intensified upwelling front within the California Current System. A companion paper outlined the evolution of the front, revealing the importance of lateral advection at tilting isopycnals and increasing stratification in the surface boundary layer with a buoyancy flux equivalent to 2000 W m−2. Here, observations were compared with idealized models to explore the dynamics contributing to the stratification. A 2D model combined with a reduced form of the horizontal momentum equations highlight the importance of transient Ekman dynamics, turbulence, and thermal wind imbalance at modulating shear in the boundary layer. Specifically, unsteady frictional adjustment to the rapid decrease in wind stress created vertically sheared currents that advected horizontal gradients to increase vertical stratification on superinertial time scales. The magnitude of stratification depended on the strength of the horizontal buoyancy gradient. This enhanced stratification due to horizontal advection inhibited nighttime mixing that would have otherwise eroded stratification from the diurnal warm layer. This underscores the importance of near-surface lateral restratification for the upper ocean buoyancy budget on diel time scales.
Evaluating Warm and Cold Rain Processes in Cloud Microphysical Schemes Using OLYMPEX Field Measurements
Authors: Naeger Aaron R. , Colle Brian A. , Zhou Na , Molthan Andrew 
Published: February 2020

AbstractField observations from the Olympic Mountain Experiment (OLYMPEX) around western Washington State during two atmospheric river (AR) events in November 2015 were used to evaluate several bulk microphysical parameterizations (BMPs) within the Weather Research and Forecasting (WRF) Model. These AR events were characterized by a prefrontal period of stable, terrain-blocked flow with an abundance of cold rain over the lowland region followed by less stable, unblocked flow with more warm rain, and a shift in the largest precipitation amounts to over the windward Olympic slopes. Our WRF simulations underpredicted the precipitation by 19%–36% in the Morrison (MORR) and Thompson (THOM) BMPs and 10%–23% in the predicted particle properties (P3) BMP, with the largest underpredictions over the windward slopes during the more convective, unblocked flow conditions. Several important processes related to the BMPs led to the differences in simulated precipitation. First, the prognostic single ice category parameterization in the P3 scheme promoted a more realistic evolution of rimed particles and larger cold rain production, which led to the lowest underpredictions in precipitation among the schemes. Second, efficient melting processes associated with the production of nonspherical ice and snow in the P3 and THOM BMPs, respectively, promoted a more realistic transition to rain fall speeds within the warm layer compared to the spherical snow assumption in MORR. Last, all BMPs underpredict the contribution of warm rain processes to the surface precipitation, particularly during the unblocked flow period, which may be partly explained by too weak condensational and collisional growth processes due to the neglect of turbulence parameterizations within the schemes.
Prolific Lightning and Thunderstorm Initiation over the Lake Victoria Basin in East Africa
Authors: Virts Katrina S. , Goodman Steven J. 
Published: February 2020

AbstractThe Lake Victoria basin of East Africa is home to over 30 million people, over 200 000 of whom are employed in fishing or transportation on the lake. Approximately 3000–5000 individuals are killed by thunderstorms yearly, primarily by outflow winds and resulting large waves. Prolific lightning activity and thunderstorm initiation in the basin are examined using continuous total lightning observations from the Earth Networks Global Lightning Network (ENGLN) for September 2014–August 2018. Seasonal shifts in the intertropical convergence zone produce semiannual lightning maxima over the lake. Diurnally, solar heating and lake and valley breezes produce daytime lightning maxima north and east of the lake, while at night the peak lightning density propagates southwestward across the lake. Cluster analysis reveals terrain-related thunderstorm initiation hot spots northeast of the lake; clusters also initiate over the lake and northern lowlands. The most prolific clusters initiate between 1100 and 1400 LT, about 1–2 h earlier than the average cluster. Most daytime thunderstorms dissipate without reaching Lake Victoria, and annually 85% of clusters producing over 1000 flashes over Lake Victoria initiate in situ. Initiation times of prolific Lake Victoria clusters exhibit a bimodal seasonal cycle: equinox-season thunderstorms initiate most frequently between 2200 and 0400 LT, while solstice-season thunderstorms initiate most frequently from 0500 to 0800 LT, more than 12 h after the afternoon convective peak over land. More extreme clusters are more likely to have formed over land and propagated over the lake, including 36 of the 100 most extreme Lake Victoria thunderstorms. These mesoscale clusters are most common during February–April and October–November.
The effect of flow and pressure on the intraoxygenator flow path of different contemporary oxygenators: an in vitro trial
Authors: Hendrix Rik HJ , Yeung Alexander KS , Ganushchak Yuri M , Weerwind Patrick W 
Published: February 2020

Introduction: This study analyzed the effect of different flows and pressures on the intraoxygenator flow path in three contemporary oxygenators and its consequences for oxygen transfer efficiency. Methods: In an experimental setup, intraoxygenator flow path parameters were analyzed at post-oxygenator pressures of 150, 200, and 250 mm Hg and at flows ranging from 2 L/min to the oxygenators’ maximum permitted flow, with and without pulsatility. The oxygen gradient and the oxygen transfer per minute and per 100 mL blood were calculated using previously collected clinical data and compared with the flow path parameters. Results: Increasing pressure did not affect the flow path parameters, whereas pulsatile flow led to significantly increased dynamic oxygenator blood volumes. Increased flow resulted in decreased values of the flow path parameters in all oxygenators, indicating increased flow through short pathways in the oxygenator. In parallel, oxygen transfer/100 mL blood decreased in all oxygenators (average 2.5 ± 0.4 to 2.4 ± 0.3 mL/dL, p > 0.001) and the oxygen gradient increased from 229 ± 45 to 287 ± 29 mm Hg, p > 0.001, indicating decreased oxygen transfer efficiency. Oxygen transfer/min increased (101 ± 15 to 143 ± 20 mL/min/m2, p > 0.001), however, due to the increased flow through the oxygenator. Conclusion: Varying trans-membrane oxygenator pressures did not lead to changes in the intraoxygenator flow path, while an increased flow exhibited lower flow path parameters resulting in less efficient use of the gas exchange compartment. The latter was confirmed by a decrease in O2 transfer efficiency during higher blood flows.
Effect of CKD–MBD phenotype on health-related quality of life in patients receiving maintenance hemodialysis: A cross-sectional study
Authors: Luo Laimin , Chen Qinkai 
Published: February 2020

Objective This study aimed to investigate the factors influencing health-related quality of life (HRQoL) in patients with different chronic kidney disease–mineral and bone disorder (CKD–MBD) phenotypes. Methods Patients undergoing maintenance hemodialysis (MHD) at our center from 1 July to 31 August 2017 were enrolled. Patients who received hemodialysis for less than 3 months or displayed poor compliance, or those with incomplete clinical data were excluded. QoL was evaluated using the Kidney Disease Quality of Life–Short Form (KDQOL-SF™) 1.3 scale. The influential factors were stratified based on different CKB–MBD phenotypes. Results There were 296 patients enrolled. The serum intact parathyroid hormone (iPTH) concentration was 436.40 ± 490.99 pg/mL, serum calcium (Ca) concentration was 2.14 ±0.27 mmol/L, serum phosphorus (P) concentration was 1.81 ± 0.56 mmol/L, the kidney disease and dialysis-related QoL (KDTA) score was 57.07 ± 10.40, and the SF-36 score was 51.45 ± 17.62. Among patients with different CKD–MBD phenotypes, HRQoL was highest in the group with an iPTH concentration of 150 to 300 pg/mL, serum Ca concentration of <2.10 mmol/L, and serum P concentration of >1.78 mmol/L. Conclusions CKD−MBD phenotypes significantly affected HRQoL. Comprehensive management of serum iPTH, Ca, and P levels is important to improve QoL in patients receiving hemodialysis.
Heparin coated meta-organic framework co-delivering doxorubicin and quercetin for effective chemotherapy of lung carcinoma
Authors: Sun Xiaojun , Li Yongxing , Xu Liang , Shi Xinyu , Xu Mengmin , Tao Xuefang , Yang Guobiao 
Published: February 2020

Objective To develop and evaluate a drug delivery system (DDS) capable of targeting cancer cells while at the same time delivering two chemotherapeutic agents to overcome multidrug resistance (MDR). Methods This study developed a DDS composed of heparin (HA)-coated meta-organic framework (MOF) nanoparticles (HM) designed to deliver doxorubicin (Dox) and quercetin (Que). A range of in vitro and in vivo studies were conducted to determine the characteristics of the HM/Dox/Que nanoparticles, their ability to produce cytotoxic effects in Dox-resistant A549/Dox cells and target and treat solid tumours in a mouse xenograft model of human lung carcinoma. Results This study demonstrated that the HM/Dox/Que nanoparticles reduced cell viability, increased apoptosis, arrested cells in the G0/G1 phase of the cell cycle and reversed MDR in A549/Dox cells in vitro when compared with mono-drug delivery. In a mouse xenograft model of human lung carcinoma, the HM/Dox/Que nanoparticles targeted the tumours and reduced tumour growth as determined by tumour volume. Conclusion The use of HM/Dox/Que nanoparticles might be a viable alternative to traditional chemotherapy of lung carcinoma.
Relationship between use of screws and acetabular cup stability in total hip arthroplasty: a meta-analysis
Authors: Fei Chen , Wang Peng-Fei , Wei Wei , Qu Shuang-Wei , Yang Kun , Li Zhi , Zhuang Yan , Zhang Bin-Fei , Zhang Kun 
Published: February 2020

Objective The relationship between the use of screws and acetabular cup stability in total hip arthroplasty (THA) remains controversial. We evaluated cup stability in THA with and without the use of screws. Methods We performed a systematic literature search to identify studies on cup stability relative to the use of screws in patients undergoing THA before October 2018. Methodological quality assessment and data collection were performed by two individual reviewers. Meta-analysis was performed using Review Manager version 5.3.5. Results We included seven trials involving 1402 patients (1469 THAs): 767 patients (809 THAs) with screws and 635 patients (660 THAs) without screws. The findings of meta-analysis indicated that uncemented acetabular component fixation with the use of additional screws was not correlated with migration of the cup, migration on roentgen stereophotogrammetry, or reoperation after THA. Moreover, operation time was not significantly different according to whether screws were used. There was no relationship between use of additional screws and osteoporosis or Harris Hip Score; however, THA with or without the use of screws might be related to bone sclerosis in the C1 region. Conclusion Currently, limited evidence shows that the use of screws during THA may not improve cup stability.
Inhibition of phosphodiesterase suppresses allergic lung inflammation by regulating MCP-1 in an OVA-induced asthma murine model with co-exposure to lipopolysaccharide
Authors: Lee Chang Doo , Choi Won Seok , Choi Yong Geon , Kang Hyun Sik , Lee Wang Tae , Kim Hong Jo , Lee Ji-Yun 
Published: February 2020

Objective Asthma is a chronic inflammatory disease that can lead to severe problems with the respiratory system. This study aimed to evaluate the suppression of allergic airway inflammation of an asthma murine model by 3-isobutyl-1-methylxanthine (IBMX), which is a non-specific cyclic nucleotide phosphodiesterase (PDE) inhibitor. Methods Allergic lung inflammation was evoked by ovalbumin (OVA) alone or co-exposure with lipopolysaccharide (LPS) in a murine asthma model. Results Compared with the OVA alone-treated control, co-exposure with LPS significantly enhanced allergic inflammatory responses in airway hyperresponsiveness and pathologic changes of the asthmatic mouse lung. Specifically, LPS enhanced allergic asthma through the increase of monocyte chemoattractant protein (MCP)-1 release. However, IBMX significantly suppressed specific airway resistance and tidal volume, the infiltration of eosinophils and mast cells into the lung, the levels of serum immunoglobulin (Ig)E and IgG1, and the release of Th2 cytokines (interleukin (IL)-4, IL-13, and MCP-1). IBMX attenuated the aggravation of inflammation by inhibiting MCP-1, and inhibited the infiltration of eosinophils and the production of Th2 cell-associated inflammatory mediators. Conclusion These results demonstrate the therapeutic potential of targeting the regulation of PDE activity in an aggravated chronic allergic asthmatic response after bacterial infection.
Finite element analysis of a new plate for Pauwels type III femoral neck fractures
Authors: Wang Gang , Tang Yong , Wu Xuhua , Yang Huilin 
Published: February 2020

Background A new plate for the treatment of Pauwels type III femoral neck fractures was developed, and its biomechanical stability was analyzed by the finite element method. Method Using 3-matic and UG-NX software, we constructed models of Pauwels type III femoral neck fractures with angles of 50°, 60°, and 70°. Moreover, a new femoral neck plate (NFNP) fixation model and a Pauwels screw fixation model were developed. Under axial loads of 1400 N and 2100 N, von Mises stress (VMS) distribution on the screws, peak VMS, displacement between fracture fragments, and model principal strains in cancellous bone were recorded. Result The peak VMS of internal fixation in the two models was mostly located near the fracture line, and the screw closest to the femoral calcar experienced maximum stress. With a Pauwels angle of 50°, 60°, and 70°, the peak VMS values of the new plates were lower than in the Pauwels screw. The displacement of fracture fragments in the NFNP was smaller than in the Pauwels screw, and peak VMS values of cancellous bone in the NFNP were lower than in the Pauwels screw. Conclusion The newly developed plate provided excellent biomechanical stability for Pauwels type III femoral neck fractures.
Mitochondrial genome-wide association study of migraine – the HUNT Study
Authors: Børte Sigrid , Zwart John-Anker , Skogholt Anne Heidi , Gabrielsen Maiken Elvestad , Thomas Laurent F , Fritsche Lars G , Surakka Ida , Nielsen Jonas B , Zhou Wei , Wolford Brooke N , Vigeland Magnus D , Hagen Knut , Kristoffersen Espen Saxhaug , Nyholt Dale R , Chasman Daniel I , Brumpton Ben M , Willer Cristen J , Winsvold Bendik S 
Published: February 2020

Background Variation in mitochondrial DNA (mtDNA) has been indicated in migraine pathogenesis, but genetic studies to date have focused on candidate variants, with sparse findings. We aimed to perform the first mitochondrial genome-wide association study of migraine, examining both single variants and mitochondrial haplogroups. Methods In total, 71,860 participants from the population-based Nord-Trøndelag Health Study were genotyped. We excluded samples not passing quality control for nuclear genotypes, in addition to samples with low call rate and closely maternally related. We analysed 775 mitochondrial DNA variants in 4021 migraine cases and 14,288 headache-free controls, using logistic regression. In addition, we analysed 3831 cases and 13,584 controls who could be reliably assigned to a mitochondrial haplogroup. Lastly, we attempted to replicate previously reported mitochondrial DNA candidate variants. Results Neither of the mitochondrial variants or haplogroups were associated with migraine. In addition, none of the previously reported mtDNA candidate variants replicated in our data. Conclusions Our findings do not support a major role of mitochondrial genetic variation in migraine pathophysiology, but a larger sample is needed to detect rare variants and future studies should also examine heteroplasmic variation, epigenetic changes and copy-number variation.
Have the IHS Guidelines for controlled trials of acute treatment of migraine attacks been followed? Laying the ground for the 4th edition
Authors: Alpuente Alicia , Tassorelli Cristina , Diener Hans-Christoph , Silberstein Stephen D , Pozo-Rosich Patricia 
Published: February 2020

Background The International Headache Society (IHS) has published four editions of Guidelines for acute clinical trials in migraine in the past 28 years. This continuous update process has been driven by the increasing amount of scientific data in the field of migraine and by the need to continuously improve the quality of trials. Objectives To illustrate: i) the results of the analysis on the adherence of published trials to the 3rd edition published in 2012, in order to identify the critical areas that needed to be addressed in the 4th edition and ii) the changes introduced in this latter edition for improving adherence and methodology robustness. Methods We searched and reviewed all controlled trials on acute treatment of migraine published in the period 2012–2018 and we assessed their adherence to the 3rd edition of the IHS Guidelines using a score system based on the most important recommendations. Afterwards, we compared the two editions of the Guidelines and assessed the changes between them. Results We included data from 24 controlled clinical trials. Most trials had a randomized double-blind controlled (RDB) design, while a minority (16.7%) were non-randomized double-blind trials. Less than half (44.6%) of the RDB trials used the recommended “pain-free at 2 hours” endpoint as the primary efficacy measure. Trial design and evaluation of results were the areas that diverged the most from the recommendations. Conclusion Adherence to IHS guidelines for clinical trials has been suboptimal so far. The new edition has been adapted and optimized to facilitate uptake and strengthen the quality of evidence.