bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vergleich von 180-Watt-XPS-Greenlight-Laserung und transurethraler Elektroresektion der Prostata: Patienten- und Personalkomfort in der klinischen Routine
Authors: Lichtenberg Tobias , Wiedemann Andreas , Heppner Hans-Jürgen 
Published: February 2020

Zusammenfassung
Einleitung Die transurethrale Prostata-Resektion (TUR-P) gilt als Goldstandard in der operativen Behandlung des benignen Prostatasyndroms (BPS). Neben der klassischen TUR-P existieren zahlreiche technische Modifikationen des Verfahrens. Neuerdings erfahren auch Laserverfahren wie die 180-Watt-XPS™-Greenlight-Laserung der Prostata (GLL) eine größere Verbreitung.
Zielsetzung Die TUR-P und die GLL wurden bereits hinsichtlich ihrer Sicherheit, Effektivität und Ökonomie verglichen. Die vorliegende Studie beleuchtet Aspekte des postoperativen Patientenaufenthaltes und des Patientenkomforts z. B. anhand der Katheterdicke, der Spülungsintensität und des Schmerzscores.
Methoden: Anhand anonymisierter Patientenkurvenblätter und Schmerzerfassungsbögen wurden die Daten von 100 TUR-P- und 150 GLL-Patienten retrospektiv erfasst. Betrachtet wurden Prostataresektat-Gewicht (TUR-P), Energieabgabe (GLL), Prostatavolumen, Status der Gerinnungskompromittierung, Außendurchmesser und Liegedauer des Harnblasenkatheters, Dauer der Harnblasenspülung, Länge des stationären Aufenthaltes und postoperativer Schmerzverlauf.
Ergebnisse Dabei zeigte sich kein signifikanter Unterschied im Prostatavolumen (p = 0,434). In der GLL-Gruppe fand sich ein signifikant höherer Anteil gerinnungskompromittierter Patienten (p < 0,0001). Der Außendurchmesser des intraoperativ eingebrachten Harnblasenkatheters unterschied sich nicht signifikant (p = 0,102). Die Liegedauer des Katheters und die Dauer der Harnblasenspülung waren in der GLL-Gruppe signifikant kürzer (p = 0,016 und p = 0,01). Bez. der Dauer des stationären Aufenthaltes zeigte sich die Tendenz zu einem kürzeren Aufenthalt nach GLL, ohne statistische Signifikanz zu erreichen (p = 0,233). Beide Behandlungsmethoden gingen mit geringen Schmerzen einher, welche kurz nach der Operation maximal ausgeprägt waren.
Zusammenfassung Die erfassten Unterschiede zeichnen die GLL – ein Verfahren, dem in der klinischen Routine gezielt gerinnungskompromittierte und multimorbide Patienten zugewiesen wurden – als Behandlungsmethode mit hohem postoperativem Patientenkomfort und Einsparpotenzial im pflegerischen Ressourcenverbrauch (Spülungsintensität und -dauer) aus.
Percutaneous or Side-Arm Graft Right Subclavian Artery Cannulation via Median Sternotomy
Authors: Cavozza Corrado , Campanella Antonio , Pasquale Pellegrino , Audo Andrea 
Published: February 2020

AbstractSeveral cannulation sites alternative to the ascending aorta, such as femoral, right axillary, carotid, innominate artery, and, less commonly, apical sites, have been proposed. Cannulation of the right subclavian artery, through sternotomy, is one possible means of establishing cardiopulmonary bypass, hence avoiding a second surgical incision. In our experience, cardiopulmonary bypass flow was adequate and circulatory arrest with antegrade cerebral perfusion was successfully performed in all cases. There was no in-hospital mortality.
Metaphtonymy in the naming procedure of technological devices among South Tunisian old people
Authors: Boubakri Awatef , Boubakri Feten 
Published: February 2020

Abstract
The present research studies the naming procedure of technological devices among South Tunisian old people. This
study is a reconsideration of the findings of Boubakri (2015) making use of the data
collected in an attempt to understand the phenomenon on the basis of a cognitive approach. The data is collected through
unintentional observation followed by intentional observation, and it was concluded that old people’s naming procedure is dictated
by their internal sensory makeup (Boubakri 2015: 166). On the basis of the collected
data and others collected for the purpose of the present research, it is concluded that the cognitive concept of construal lies
behind old people’s naming procedure of technological devices, and that the internal cognitive factor involved in the emergence of
the construal is metaphor. More precisely, this metaphor is mataphtonymy which is basically motivated by the psychological state
of its user.
The effects of fatiguing exercise and load carriage on the perception and initiation of movement
Authors: Johnson Caleb D. , Eagle Shawn R. , Nindl Bradley C. , Lovalekar Mita T. , Flanagan Shawn D. , Pepping Gert‐Jan , Connaboy Christopher 
Published: February 2020

AbstractPerceptual‐motor coordination relies on the accurate coupling of the perceptual and movement systems. However, individuals must also be able to recalibrate to perturbations to perceptual and movement capabilities. We examined the effects of fatigue and load carriage on perceptual‐motor coordination for a maximal leaping task. 23 participants completed an incremental fatigue protocol (light to fatiguing intensity stages) on two separate occasions (loaded/unloaded). At baseline and the end of every stage of the protocol, participants made perceptual judgments for the affordance of leaping. The accuracy of responses and reaction times were calculated and mean differences were assessed across exercise intensity and load carriage conditions. No interaction of exercise intensity and load carriage was detected, or main effect of load carriage. A main, quadratic effect of exercise intensity was detected on reaction times, with times decreasing through the moderate stage and increasing through post‐fatigue. No effect of exercise/fatigue was detected on perceptual accuracy. The results indicate that exercise at high intensities through fatigue has a significant effect on perceptual‐motor calibration. Contrastingly, in response to an action‐scaled task, individuals can adequately recalibrate to increased load carriage.
MIFlowCyt‐EV: a framework for standardized reporting of extracellular vesicle flow cytometry experiments
Authors: Welsh Joshua A. , Van Der Pol Edwin , Arkesteijn Ger J.A. , Bremer Michel , Brisson Alain , Coumans Frank , Dignat‐George Françoise , Duggan Erika , Ghiran Ionita , Giebel Bernd , Görgens André , Hendrix An , Lacroix Romaric , Lannigan Joanne , Libregts Sten F.W.M. , Lozano‐Andrés Estefanía , Morales‐Kastresana Aizea , Robert Stephane , De Rond Leonie , Tertel Tobias , Tigges John , De Wever Olivier , Yan Xiaomei , Nieuwland Rienk , Wauben Marca H.M. , Nolan John P. , Jones Jennifer C. 
Published: February 2020

ABSTRACTExtracellular vesicles (EVs) are small, heterogeneous and difficult to measure. Flow cytometry (FC) is a key technology for the measurement of individual particles, but its application to the analysis of EVs and other submicron particles has presented many challenges and has produced a number of controversial results, in part due to limitations of instrument detection, lack of robust methods and ambiguities in how data should be interpreted. These complications are exacerbated by the field's lack of a robust reporting framework, and many EV‐FC manuscripts include incomplete descriptions of methods and results, contain artefacts stemming from an insufficient instrument sensitivity and inappropriate experimental design and lack appropriate calibration and standardization. To address these issues, a working group (WG) of EV‐FC researchers from ISEV, ISAC and ISTH, worked together as an EV‐FC WG and developed a consensus framework for the minimum information that should be provided regarding EV‐FC. This framework incorporates the existing Minimum Information for Studies of EVs (MISEV) guidelines and Minimum Information about a FC experiment (MIFlowCyt) standard in an EV‐FC‐specific reporting framework (MIFlowCyt‐EV) that supports reporting of critical information related to sample staining, EV detection and measurement and experimental design in manuscripts that report EV‐FC data. MIFlowCyt‐EV provides a structure for sharing EV‐FC results, but it does not prescribe specific protocols, as there will continue to be rapid evolution of instruments and methods for the foreseeable future. MIFlowCyt‐EV accommodates this evolution, while providing information needed to evaluate and compare different approaches. Because MIFlowCyt‐EV will ensure consistency in the manner of reporting of EV‐FC studies, over time we expect that adoption of MIFlowCyt‐EV as a standard for reporting EV‐ FC studies will improve the ability to quantitatively compare results from different laboratories and to support the development of new instruments and assays for improved measurement of EVs.
Nuclear physics research at heavy ion accelerators: Precision studies with stored and cooled exotic nuclei
Authors: Litvinov Yuri A , Stöhlker Thomas , Ma Xin Wen , Zhang Yu Hu , Yamaguchi Takayuki 
Published: February 2020

Abstract
This contribution is based on the plenary presentation at the 14th International Conference on Heavy Ion Accelerator Technology (HIAT-2018) in Lanzhou, China.
Heavy-ion storage rings offer unparalleled opportunities for precision experiments in the realm of nuclear structure, atomic physics and astrophysics. A brief somewhat biased review of the presently ongoing research programs is given as well as the future projects are outlined. The limited space does not allow for detailed description of individual experiments, which shall – to some extent – be compensated by extended bibliography.
High Voltage Performance Degradation of the 14UD Tandem Accelerator
Authors: Linardakis P , Lobanov N R , Tunningley T B , Tsifakis D , Battisson S T , Graham B , Bockwinkel J A , Heighway J 
Published: February 2020

Abstract
The 14UD at the Australian National University’s Heavy Ion Accelerator Facility (HIAF) operated at a maximum voltage of 15.5 MV after the installation of tubes with a compressed geometry in the 1990s. In recent years, the performance of the accelerator has shown a gradual decline to a maximum operation voltage of ~14.5 MV. There are some fundamental factors that limit the high voltage performance, such as SF6 gas pressure, field enhancement due to triple junctions and total voltage effect. In addition, there are non-fundamental factors causing high voltage degradation. These are: operation with faulty ceramic gaps; operation at inappropriate voltage and SF6 pressure combinations; SF6 leaks into the vacuum space; use of SF6 and O2 as a stripper gases; poor electron suppression in the high energy stripper and frequent use of highly reactive ions such as sulphur and fluorine. In this paper we will discuss factors that limit the high voltage performance. The main outcomes of a preliminary investigation of titanium (Ti) electrodes removed from the accelerator after a few decades of operation will be reported. The investigation confirmed contamination of Ti electrodes with unstable films containing traces of oxides, sulphur and fluorine. The rehabilitation strategies for the accelerator will be discussed.
Present status of and recent developments at RIKEN RI beam factory
Authors: Okuno H. , Dantsuka T. , Fujimaki M. , Fukunishi N. , Hasebe H. , Higurashi Y. , Ikezawa E. , Ikoma N , Imao H. , Kamigaito O. , Kidera M. , Komiyama M. , Kumagai K. , Maie T. , Nagase M. , Nagatomo T. , Nakagawa T. , Nakamura M. , Ohnishi J. , Ozeki K. , Sakamoto N. , Suda K. , Uchiyama U. , Watanabe S. , Watanabe T. , Watanabe Y. , Yamada K. , Yamasawa H. 
Published: February 2020

Abstract
The Radioactive Isotope Beam Factory (RIBF) is a cyclotron-based accelerator facility that is used for nuclear science studies and was completed at the end of 2006. RIBF can produce the most intense RI beams using fragmentation or fission of high speed heavy ion beams. Ever since the first beam was produced, effort has focused on increasing the intensity of uranium beams. Ions beams with high intensity and high availability have been used to produce many important scientific achievements. Upgrade programs have been proposed to further expand scientific opportunities. These programs have two goals. The first goal is to find heavier elements than element 118, which is already named. The upgrade program for the heavy ion linac (RILAC), including installation of a superconducting linac, has been funded and is under construction. The second goals is to increase the intensity of uranium ion beams up to 1 pµA, thus facilitating further investigations into the physics of unstable nuclei. This program for uranium beams is still been unfunded. We are pursuing a budget-friendly version without changing the project goals.
Design of the multi-ion injector linac for the JLAB EIC (JLEIC)
Authors: Mustapha B. , Conway Z. , Kelly M. , Plastun A. , Ostroumov P. 
Published: February 2020

Abstract
An Electron Ion Collider (EIC) is the highest priority for future U.S. accelerator-based nuclear physics facility following the completion of the Facility for Rare Isotope Beams (FRIB). Two laboratories are competing to host the future EIC: Brookhaven National Lab. (BNL) and Jefferson Lab. (JLab). The baseline design of JLab’s Electron Ion Collider (JLEIC) ion complex comprises a pulsed superconducting (SC) linac injector capable of accelerating all ions from protons to lead, where proton and light ion beams can be polarized. After reviewing the design requirements for the injector linac, important design choices such as the room-temperature (RT) section design, the transition energy between the RT and SC sections and the stripping energy for heavy ions will be discussed. The design of the different linac sections will be presented as well as the results of end-to-end beam dynamics simulations for polarized deuterons and un-polarized lead ions.
Preliminary design and simulation results of a Ne+ beam source
Authors: Xie Y H , Hu C D , Xu Y J , Li J , Xie Y L 
Published: February 2020

Abstract
An ion source with Ne beam was designed to provide fast ions for basic physical research in the Institute of Plasma Physics, Chinese Academy of Science (ASIPP). The ion source was designed with hot cathode plasma source and three electrodes accelerator. The designed beam energy is 10-20 keV with beam size of 250 mm × 250 mm. The designed beam power is 50 kW with beam duration of 2 seconds. The extracted beam current and beam divergence angle was simulated to estimate the beam parameters with beam energy of 10 keV and 20 keV. The details of simulation results and the design of source was presented in this paper.
The multi-physics field analysis of a dual-beam drift tube linac
Authors: He T , Lu L , Yang L , Xing C , Xu X , Gao Z , Li J , Xia Q 
Published: February 2020

Abstract
An 81.25 MHz dual-beam drift tube linac (DB-DTL) is being designed to prove the feasibility of multi-beam type linac. The beam dynamics design and electromagnetic calculation have been completed [1]. The following step is the multi-physics field analysis of the DB-DTL, including RF electromagnetic simulation, thermal simulation and structural simulation, which is very important for the DB-DTL safe operation. The RF power dissipation will make the cavity temperature rise and cause cavity resonance frequency shifts due to the deformation of cavity structure. The distributions of cavity deformation and stress are calculated according to the cavity temperature map. All the simulation results, including cavity temperature rise, deformation and stress and the frequency shifting, should be within an acceptable range. In this paper, the detailed multi-physics analysis of the DB-TL will be presented.
A new RF structure: bent-vane type RFQ
Authors: Yang Lei , Lu Liang , Zhang Zhouli , He Tao , Xing ChaoChao , He Yaun 
Published: February 2020

Abstract
A new RFQ accelerator cavity structure with bent vanes is proposed to meet the miniaturization requirement of low frequency accelerators. The news structure has a downsized cross section by bending the vanes while maintaining a certain vane length. It also possesses the advantage of a simple cooling configuration. The new RFQ structure is presented in this paper.
Change in FGF23 concentration over time and its association with all-cause mortality in patients treated with haemodialysis or haemodiafiltration
Authors: Bouma-de Krijger Annet , de Roij van Zuijdewijn Camiel L M , Nubé Menso J , Grooteman Muriel P C , Vervloet Marc G ,   the CONTRAST Study Group, Blankestijn P J , Grooteman M P C , Nubé M J , ter Wee P M , Bots M L , van den Dorpel M A 
Published: February 2020

Abstract

Background
Previous studies in patients on haemodialysis (HD) have shown an association of fibroblast growth factor 23 (FGF23) with all-cause mortality. As of yet, the result of FGF23 lowering on mortality is unknown in this population.

Methods
FGF23 was measured in a subset of 404 patients from the Dutch CONvective TRansport STudy (CONTRAST study) [a randomized trial in prevalent dialysis patients comparing HD and haemodiafiltration (HDF) with clinical outcome] at baseline and Months 6 and 12. A substantial decline of FGF23 change over time was anticipated in patients randomized to HDF since HDF induces higher dialytic clearance of FGF23. The associations of both baseline FGF23 and 6-months change in FGF23 with all-cause mortality were analysed. In addition, the difference in FGF23 change between HD and HDF was explored. Furthermore, the role of dialysis modality in the association between FGF23 change and outcome was analysed.

Results
No association was observed between quartiles of baseline FGF23 and all-cause mortality. Over 6 months, FGF23 declined in patients on HDF, whereas FGF23 remained stable in patients on HD. A decrease in FGF23 was not associated with improved survival compared with a stable FGF23 concentration. However, increasing FGF23 was associated with a significantly higher mortality risk, both in crude and fully adjusted models [hazard ratio 2.01 (95% confidence interval 1.30–3.09)].

Conclusion
Whereas no association between a single value of FGF23 and all-cause mortality was found, increasing FGF23 concentrations did identify patients at risk for mortality. Since lowering FGF23 did not improve outcome, this study found no argument for therapeutically lowering FGF23.
Extraction and determination of chloroform in rat blood and tissues by gas chromatography-electron-capture detection: distribution of chloroform in the animal body.
Authors: Vogt C R , Liao J C , Sun A Y 
Published: February 2020

Abstract
We have developed a simple, sensitive, and accurate method for the determination of chloroform in rat blood, brain, kidney, liver, and fat. The detection limit is 2.5 ng of chloroform per gram of tissue. Studies of in vivo distribution of chloroform in rat blood and target tissues after intragastric intubation of chloroform/water show that the amount of chloroform accumulated in the different tissues increases with increasing doses. Fat tissue contains the greatest amount of chloroform. The accumulation of chloroform in rat blood and target tissues seems to be maximum 1.5 h after administration, and the apparent chloroform concentration is almost at baseline value 8 h later.
Pre-precipitated and solid-phase second antibody compared in radioimmunoassay.
Authors: Brown T R , Bagchi N , Ho T T , Mack R E 
Published: February 2020

Abstract
We describe simple methods for preparing and determining the titer of pre-precipitated second antibody. We compared the performance of this type of insolubilized second antibody with that of a commercially available solid-phase second antibody (DASP) for separation of reverse triiodothyronine (rT3) and for thyrotropin radioimmunoassays. Equilibrium time for both reagents was about 30 min, considerably briefer than for the usual second-antibody procedure. Within-assay precision was improved and percentages of nonspecific binding (mean and SD) were lower if pre-precipitated second antibody was used in both assays [rT3 pre-precipitate = 1.48 (SD 0.16), rT3 DASP = 3.76 (SD 0.22); thyrotropin pre-precipitate = 1.45 (SD 0.18), thyrotropin DASP = 3.45 (SD 0.26)]. The cost of DASP was three to 10 times that of pre-precipitated second antibody prepared with commercially available products.
Potential sources of errors in cation-exchange chromatographic measurement of plasma taurine.
Authors: Connolly B M , Goodman H O 
Published: February 2020

Abstract
We examined the potential sources of error in automated cation-exchange chromatographic quantitation of plasma taurine, both in sample preparation and in the analysis. Principal sources of error include: use of serum instead of plasma, which produces gross overestimates; use of tripotassium ethylenediaminetetraacetate (EDTA) as anticoagulant in systems involving ninhydrin detection (a ninhydrin-positive contaminant of EDTA emerges coincident with taurine); contamination with platelets; and placing volumes exceeding 20 microL on the cartridge used in the Technicon TSM Amino Acid Analyzer. We arrived at a simple technique in which we use EDTA as anticoagulant, micropore filtration to produce platelet-free plasma, and o-phthalaldehyde as the detection reagent for the sensitivity required to measure accurately the low concentration of taurine in plasma.
Gas-chromatographic determination of disopyramide and its mono-N-dealkylated metabolite in serum with use of a nitrogen-selective detector.
Authors: Bredesen J E 
Published: February 2020

Abstract
I describe a rapid, simple routine gas-liquid chromatographic method for simultaneous isothermal quantitation of disopyramide and its mono-N-dealkylated metabolite. The method involves one extraction step with dichloromethane, derivatization of the metabolite, and gas chromatography with an OV-17 liquid phase. Standard curves were linear over the concentration range tested (0.1-25 mg/L) and the maximum coefficient of variation was 9.2%. Quantitation of both disopyramide and its mono-N-dealkylated metabolite with the present method is less time-consuming than are gas-chromatographic methods previously described.
Improved serum-initiated aspartate aminotransferase assay by inhibition of lactate dehydrogenase with oxamate.
Authors: Lustig V , Redman L W 
Published: February 2020

Abstract
We describe a serum-inititated aspartate aminotransferase (EC 2.6.1.1) assay that obviates the need for added lactate dehydrogenase (EC 1.1.1.27) in the reagent system. Interference from the oxidation of NADH by endogeneous lactate dehydrogenase is eliminated by adding sodium oxamate, a competitive inhibitor of the enzyme. The advantages of oxamate inhibition over lactate dehydrogenase addition are a shorter preincubation period, an increase in the linear range from less than 600 to more than 1400 U/L, no interference from above-normal concentrations of ketoacids, and elimination of bias between serum-initiated and the standard oxoglutarate-initiated assays for aspartate aminotransferase.