bluuebunny/crossref_metadata_2025_split huggingface dataset:
The ameliorative effect of atorvastatin on serum testosterone and testicular oxidant/antioxidant system of HFD-fed male albino rats
Authors: Esmail Mohammed , Kandeil Mohammed , El-Zanaty Ali Mahmoud , Abdel-Gabbar Mohammed 
Published: November 2020

Background: There is a mutual effect between central obesity and low total serum testosterone. Moreover, oxidative stress acts as a bridge between obesity and its complications. Taken together, we aimed to evaluate whether atorvastatin (AS), a cholesterol-lowering drug, has protective potential against high fat diet (HFD)-induced low fertility, which was exemplified in serum testosterone determination. Moreover, we aimed to deduce a putative mechanism of action through evaluation of the testicular oxidant/antioxidant system.Methods: Adult male albino Wistar rats (Rattus norvegicus albinus) were divided into three groups: 1) normal control group, rats were fed a normal diet for four weeks; 2) HFD group, rats were fed an HFD for four weeks; and 3) AS group, rats were fed an HFD and 5 mg/kg/day atorvastatin for the last two weeks of the experiment. Serum atherogenic index, testosterone, and thyroid stimulating hormone were estimated. Moreover, testicular reduced glutathione and malondialdehyde contents, as well as glutathione-S-transferase, superoxide dismutase, and glutathione reductase activities were also determined. The statistical differences were analyzed using analysis of variance (ANOVA).Results: AS ameliorated the increased level of serum atherogenic index induced by an HFD, as well as testicular malonaldehyde and reduced glutathione levels. On the other hand, AS increased the depleted level and activity of serum testosterone and testicular glutathione reductase, respectively, induced by HFD.Conclusion:The ameliorative effect of AS on the deteriorated level of total serum testosterone induced by HFD might partially be due to oxidant/antioxidant disturbance. Further studies should be carried out to evaluate mTOR pathway contribution, which could enable researchers to deduce drugs targeting members of the oxidant/antioxidant system and/or mTOR pathway to ameliorate putative HFD-induced low fertility.
Common genetic signatures of Alzheimer’s disease in Down Syndrome
Authors: Sharma Ayati , Chunduri Alisha , Gopu Asha , Shatrowsky Christine , Crusio Wim E. , Delprato Anna 
Published: November 2020

Background:People with Down Syndrome (DS) are born with an extra copy of Chromosome (Chr) 21 and many of these individuals develop Alzheimer’s Disease (AD) when they age. This is due at least in part to the extra copy of theAPPgene located on Chr 21. By 40 years, most people with DS have amyloid plaques which disrupt brain cell function and increase their risk for AD. About half of the people with DS develop AD and the associated dementia around 50 to 60 years of age, which is about the age at which the hereditary form of AD, early onset AD, manifests. In the absence of Chr 21 trisomy, duplication of APP alone is a cause of early onset Alzheimer’s disease, making it likely that having three copies ofAPPis important in the development of AD and in DS. In individuals with both DS and AD, early behavior and cognition-related symptoms may include a reduction in social behavior, decreased enthusiasm, diminished ability to pay attention, sadness, fearfulness or anxiety, irritability, uncooperativeness or aggression, seizures that begin in adulthood, and changes in coordination and walking.Methods:We investigate the relationship between AD and DS through integrative analysis of genesets derived from a MeSH query of AD and DS associated beta amyloid peptides, Chr 21, GWAS identified AD risk factor genes, and differentially expressed genes in DS individuals.Results:Unique and shared aspects of each geneset were evaluated based on functional enrichment analysis, transcription factor profile and network analyses. Genes that may be important to both disorders:ACSM1,APBA2,APLP1,BACE2,BCL2L,COL18A1,DYRK1A,IK,KLK6,METTL2B,MTOR,NFE2L2,NFKB1,PRSS1,QTRT1,RCAN1,RUNX1,SAP18 SOD1,SYNJ1,S100B.Conclusions:Our findings indicate that oxidative stress, apoptosis, and inflammation/immune system processes likely underlie the pathogenesis of AD and DS.
Multiple insecticide resistance and Plasmodium infection in the principal malaria vectors Anopheles funestus and Anopheles gambiae in a forested locality close to the Yaoundé airport, Cameroon
Authors: Nkemngo Francis N. , Mugenzi Leon M. J. , Terence Ebai , Niang Abdoulaye , Wondji Murielle J. , Tchoupo Micareme , Nguete Nguiffo D. , Tchapga Williams , Irving Helen , Ntabi Jacques D. M. , Agonhossou Romuald , Boussougou-Sambe Terence S. , Akoton Romaric B. , Koukouikila-Koussounda Felix , Pinilla Yudi T. , Ntoumi Francine , Djogbenou Luc S. , Ghogomu Stephen M. , Ndo Cyrille , Adegnika Ayola A. , Borrmann Steffen , Wondji Charles S. 
Published: November 2020

Background:Reducing the burden of malaria requires better understanding of vector populations, particularly in forested regions where the incidence remains elevated. Here, we characterized malaria vectors in a locality near the Yaoundé international airport, Cameroon, including species composition, abundance,Plasmodiuminfection rate, insecticide resistance profiles and underlying resistance mechanisms.Methods:Blood-fed adult mosquitoes resting indoors were aspirated from houses in April 2019 at Elende, a locality situated 2 km from the Yaoundé-Nsimalen airport. Female mosquitoes were forced to lay eggs to generate F1adults. Bioassays were performed to assess resistance profile to the four insecticides classes. The threshold of insecticide susceptibility was defined above 98% mortality rate and mortality rates below 90% were indicative of confirmed insecticide resistance. Furthermore, the molecular basis of resistance andPlasmodiuminfection rates were investigated.Results:Anopheles funestuss.s. was the most abundant species in Elende (85%) followed byAnopheles gambiaes.s. (15%) with both having similar sporozoite rate. Both species exhibited high levels of resistance to the pyrethroids, permethrin and deltamethrin (<40% mortality).An. gambiaes.s. was resistant to DDT (9.9% mortality) and bendiocarb (54% mortality) while susceptible to organophosphate.An. funestuss.s. was resistant to dieldrin (1% mortality), DDT (86% mortality) but susceptible to carbamates and organophosphates. The L119F-GSTe2 resistance allele (8%) and G119Sace-1 resistance allele (15%) were detected inAn. funestuss.s. andAn. gambiaes.s., respectively.Furthermore, the high pyrethroid/DDT resistances inAn. gambiaecorresponded with an increase frequency of 1014Fkdrallele (95%). Transcriptional profiling of candidate cytochrome P450 genes reveals the over-expression ofCYP6P5,CYP6P9aandCYP6P9b.Conclusion:The resistance to multiple insecticide classes observed in these vector populations alongside the significantPlasmodiumsporozoite rate highlights the challenges that vector control programs encounter in sustaining the regular benefits of contemporary insecticide-based control interventions in forested areas.
Broadband tunable single-longitudinal-mode erbium-doped fiber ring laser based on a microfiber knot resonator
Authors: Wan Hongdan , Cai Chaoqun , Wang Jingli , Wang Jiaxuan , Chen Yufang , Zhang Zuxing 
Published: November 2020

We propose and demonstrate a broadband tunable single-longitudinal-mode (SLM) erbium-doped fiber laser based on a microfiber knot resonator (MKR). The MKR is made from a double-ended fiber taper and employed for SLM filtering based on the Vernier effect. An unpumped erbium-doped fiber is used in the fiber laser cavity to suppress mode-hopping for a stabilized SLM laser operation. When combined with an optical fiber filter, widely tunable SLM laser generation is achieved. The proposed SLM laser can be tuned from 1545 to 1565 nm with a high side-mode suppression ratio of about 55 dB and a high stability.
Orthogonally polarized tunable dual-wavelength femtosecond optical parametric oscillator
Authors: Bi Genyu , Fan Jintao , Chu Yuxi , Hu Minglie , Liu Bowen 
Published: November 2020

We demonstrate a femtosecond optical parametric oscillator that can generate orthogonally polarized dual-wavelength femtosecond pulses. Two periodically poled lithium niobate (PPLN) crystals with mutually orthogonal crystal axes are pumped by a single femtosecond fiber laser. The central wavelength of the two orthogonally polarized signal pulses can be continuously tuned from 1387 to 1588 nm with a maximum frequency separation of 27 THz. Because of the orthogonal dual-crystal scheme, the system is immune to the coherent coupling effect, thus overcoming the limitation of minimum frequency separation.
Anisotropic nonlinear optical response in a graphene oxide-gold nanohybrid
Authors: Yadav Rajesh Kumar , Aneesh J. , Sharma Rituraj , Maji Tuhin Kumar , Karmakar Debjani , Adarsh K. V. 
Published: November 2020

In this Letter, we report for the first time, to the best of our knowledge, the anisotropic optical response in a graphene oxide (GO)-gold (Au) nanohybrid. Polarization-sensitive nonlinear optical absorption measurements revealed that nanohybrids are highly anisotropic,

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, which is more than one order of magnitude higher than that of control GO (2 cm/GW). The first-principle analysis of absorbance at nanohybrid interfaces with varying functional ligand concentrations corroborates with the experimentally observed intrinsic linear anisotropy. Thus, this Letter enables new routes to realize smart and high-performing nonlinear optical systems selectively and directionally such as tunable optical limiters and optical data processing devices.
Determining behavioral intention and its predictors towards cervical cancer screening among women in Gomma district, Jimma, Ethiopia: Application of the theory of planned behavior
Authors: Wollancho Wadu , Amdissa Demuma , Bamboro Shemsedin , Wasihun Yitbarek , Tareke Kasahun Girma , Gizaw Abraham Tamirat 
Published: November 2020

BackgroundCervical Cancer is the leading cause of cancer-related deaths among Ethiopian women. Despite many interventions were conducted, there is low uptake of cervical cancer screening services. Also, limited evidence was available on the women’s intention and its predictors towards cervical cancer screening. Therefore, this study was aimed at determining the intention and predicators of behavioral intention toward cervical cancer screening.MethodsA cross-sectional study was conducted in the Gomma district, Jimma, Ethiopia from August 1–30, 2019. The total sample sizes were 422 and a systematic random sampling technique was employed to select the samples. Data were collected through interviews using a structured questionnaire guide. Data were entered in epidata, and exported and analyzed using SPSS version 20.0 software. Descriptive, correlation, and multicollinearity analysis were done. Also, simple and multiple linear regression analysis were performed to identify the predictors for behavioral intention. The p-value<0.05 was used to declare a significant association.ResultThe response rate was 382 (90.5%). The mean age of the participants was of 26.45 (SD = 4.76). Direct attitude, subjective norm, and perceived behavioral control had a mean score of 16.78 (SD = 2.87), 15.61(SD = 1.92), and 12.86 (SD = 4.85), respectively. The intention has a mean score of 14.52 (SD = 4.01). From regression analysis, direct attitude (B = 0.346, p<0.001), direct subjective norm (B = 0.288, p = 0.008), direct perceived behavioral control (B = 0.132, p = 0.002) indirect attitude (B = 0.015, p = 0.019) and the indirect perceived behavioral control (B = 0.132, p = 0.002) were statistically significant with intention.ConclusionFrom this study, it was understood that women’s intention towards cervical cancer screening was low. The predictors were the direct and indirect attitude, direct and indirect subjective norm, direct and indirect perceived behavioral control. This calls a need to develop strategies and take action to improve the attitude of women and their influential peoples and increase sense of control to improve their intention to screen for cervical cancer. Moreover, health care providers should have to conduct social and behavioral change communication to improve women’s health seeking behavior towards cervical cancer screening applying the concept of theory of planned behavior.
Programs of Recursive Analytical Calculations in Problems of Random Point Images Analysis
Authors: Reznik A.L. , Soloviev A.A. , Torgov A.V. 
Published: November 2020

The paper discusses an approach to solving complex probabilistic combinatorial problems. The approach is based on the use of specialized software systems for analytical transformations for computing systems. One of the problems associated with the partition of the interval (which arises in the study of the reliability of reading discrete-point fields and digital images) is considered in the paper, and new previously unknown analytical formulas have been successfully obtained. The efficiency of the developed software systems is ensured by two factors: firstly, the development of high-speed specialized recursive-combinatorial algorithms; secondly, the software implementation on high-performance computing clusters using modern programming and development tools (such as C ++ and MPI).
Examples of particular solutions to the described problem that are obtained with the help of constructed computer systems are presented. An effective approach to solving complex probabilistic combinatorial problems is demonstrated. For the proposed approach, a computer is not just a powerful "calculator", but is an effective assistant with a wide range of algorithms and programs for complex and branched analytical transformations.
Quantifying Polymer Loading in Bentonite-Polymer Composites Using Loss on Ignition and Total Carbon Analyses
Authors: Gustitus Sarah A. , Nguyen Dorian , Chen Jiannan , Benson Craig H. 
Published: November 2020

Abstract
Three methods were evaluated to measure polymer loading in bentonite-polymer composites (BPCs): component loss on ignition (LOI), composite LOI, and composite total carbon (TC). Component methods are based on a series of measurements (e.g., LOI) conducted independently on bentonite and polymer components. Composite methods are based on a series of measurements (e.g., LOI or TC) conducted on BPCs with known polymer loadings. All three methods were evaluated using three different BPCs, with polymer loading ranging from 20 to 100 g polymer/kg BPC. Polymer loading measured with the component LOI method was biased because of the effects of the bentonite on thermal degradation reactions occurring in the polymer component. Polymer loading of unhydrated BPCs measured with the composite LOI or TC methods showed no polymer-dependent bias. Measured polymer loading deviated from actual polymer loading by an average of −3.3 to 0.1 g polymer/kg BPC for the composite LOI method, and by an average of 2.5 to 3.8 g polymer/kg BPC for the composite TC method. Hydration of the BPCs influenced the accuracy of the composite LOI method, which produced consistently lower polymer loading measurements for BPCs hydrated with DI water than 50 mM CaCl2. In contrast, polymer loading measured with the composite TC method was not measurably different for hydrated and unhydrated samples. The composite LOI method is recommended for quality control testing on BPCs prior to hydration, whereas the composite TC method is recommended for testing BPCs prior to and/or following hydration.
Preliminary Assessment of Electro-Chemical Machining for Aluminum Parts Produced by Laser-Based Powder Bed Fusion
Authors: Defanti Silvio , Denti Lucia , Vincenzi Nicolò , Gatto Andrea 
Published: November 2020

Abstract
Electro-chemical machining (ECM) is a nonconventional machining process based on the anodic dissolution of the workpiece. The peculiar features of this process make it suitable for application in the aerospace, automotive, or medical fields where laser-based powder bed fusion (L-PBF) is consolidating as a manufacturing solution for high-performance components. The roughness of as-built L-PBF parts often requires surface finishing before usage in order to enable a correct operation as well as to prevent early fatigue failure. The viability of ECM on L-PBF components is still scarcely investigated in the literature. In this article, the process was applied to AlSi10Mg parts produced by L-PBF. An experimental plan was designed to select the process parameters and to study their effect on the surface roughness and morphology. Process variables including feed rate, time, voltage, and water pressure were investigated. As a result, it was observed that the ECM performance was different for parts produced by traditional processes or by L-PBF, even for comparable composition. Owing to the presence of satellite particles on L-PBF surfaces, ECM was only effective in the pulsed mode.
El control interno de los inventarios: su incidencia en la gestión financiera de “Due Amici Pizzería”
Authors: Restrepo María Consuelo , Chamorro González Candy , Carvajal Serna Diego 
Published: November 2020

La gestión y el control del inventario son características cruciales para garantizar los segmentos financieros de las pequeñas y medianas empresas. Por tanto, la investigación está orientada a describir el manejo del control interno de los inventarios y su incidencia en la gestión financiera de la empresa Due Amici Pizzería. La metodología es contemplada desde el enfoque cualitativo y sustentada en un estudio de caso. Los resultados destacan que existen operaciones y mecanismos de entornos inciertos e imprecisos debido a la inexistencia formal de un sistema de inventarios en Due Amici Pizzeria, así mismo, el restaurante presenta falencias en el establecimiento de políticas, lineamientos y procesos necesarios para un adecuado control interno de los inventarios que impiden a su vez mejores resultados en la gestión financiera de la empresa e inciden en la rentabilidad de la organización. Por ende, es pertinente la generación de estrategias ante los procesos más débiles que mantiene la organización.
Temas y motivos de los discursos en prosa de la Academia de Nocturnos de Valencia
Authors: Rodríguez Cachón Irene 
Published: November 2020

La aparición en España, a partir de mediados del siglo xv, de diferentes grupos eruditos reunidos bajo el nombre de «academias» supuso un creciente interés por el texto argumentativo previo al debate que generaban. Uno de los grupos más conocidos, por el nombre de alguno de los participantes y por la calidad de los textos que se presentaron, fue la Academia de Nocturnos de Valencia (1591-1594), alrededor de la cual sus miembros se reunían una vez por semana para leer poesía o discutir y polemizar a partir de ensayos, críticas, etc. En sus tres años de vida, la Academia de Nocturnos de Valencia celebró un total de 88 sesiones y se presentaron 805 composiciones en verso y 88 discursos en prosa. Este trabajo pretende clasificar esos 88 discursos en prosa y analizar qué temas predominaron en ese afán tan característico del Humanismo español del culto del hombre por el hombre.
WORLD WIDE TRENDS IN MOTOR VEHICLE EMISSION STANDARDS
Authors: Green R.A. 
Published: November 2020

The emissions front the combustion of fossil fuels are receiving greater attention now that they have for some years. Realisation that the standards designed to control emissions need to be continually reviewed to match the changing industrial environment is leading to much more concern over the issue. Measures which were thought to be sufficient to contain the problem, me now being shown in some cases, to be inadequate.
In order to meet the regulations being adopted throughout the world, engine manufacturers and fuel suppliers have been required to devise new technologies. This has led to a greater awareness, in both of these industries, of the effects that new technology can have on ambient air quality.
Experiences over many yews in other pans of the M'0dd has provided this county with the opportunity to study the end result of different regulatory standards and their long term effects, and to draw meaningful conclusions when considering the directions which should be taken in order to answer that our future generations do not suffer.
DEVELOPING OF PERFORMING ARTS AS A TOURIST ATTRACTION TO IMPROVE THE QUALITY OF TOURIST EXPERIENCES AT SAUNG ANGKLUNG UDJO
Authors: Mulyana Deni 
Published: November 2020

This study aimed at analyzing the elements of performance, the programme of performance, and the actual condition of tourism product in Saung Angklung Udjo Bandung. Performance is very important to create positive and negative experiences for the audience because it is presented to others. To find out whether the performing arts that are displayed are good, it necessary to have a response from tourists who watched the show. Problems arose in this research are as follows: 1) How are tourism products in Saung Angklung Udjo Bandung?; 2) How is the appearance in performing arts as a tourist attractions at Saung Angklung Udjo Bandung?; and 3) How is the quality of the tourist experience after seeing the performing arts at Saung Angklung Udjo Bandung. The purpose of this research is to find out tourism products, appearance in performing arts tourism attractions, and the quality of the tourist experience after saw the performing arts at Saung Angklung Udjo Bandung. The method used is a qualitative method. Interviews, observation, documentation and questionnaires are used as a technique data collection. At the same time, the data analysis technique uses a Likert scale. The result showed that some improvement in the products, appearance in performing arts tourism attractions, and the quality of the tourist experience are necessary to improve at Saung Angklung Udjo Bandung.Keywords: Performing Arts, Tourism Products, Tourist Experience
THE PROBLEM OF DEVELOPMENT OF MAXILLARY SINUSITIS AFTER SINUS-LIFTING SURGERY
Authors: Remizova Ekaterina , Amkhadova Malkan , Gergieva Tamara , Amkhadov Islam 
Published: November 2020

Subject. In some clinical cases maxillary sinus lift is a nessesary surgery preparing for dental implantation in the distal parts of the upper jaw. However, despite the widespread using of this type of surgery in clinical practice, the percentage of postoperative complications leading to the development of odontogenic maxillary sinusitis after sinus-lifting surgery does not decrease from year to year. Among the complications of sinus lifting, the following main ones are distinguished: perforation of the maxillary sinus mucosa and nasal cavity; rejection of a previously installed dental implant; migration of the implant and/or bone material to the maxillary sinus; bleeding; acute maxillary sinusitis.
The aim is to conduct a systematic analysis of domestic and foreign literature sources to determine the main factors of development of postoperative odontogenic sinusitis, as well as features of diagnosis and prevention of this complication.
Methodology. The review of research allows us to consider the etiology of odontogenic maxillary sinusitis after sinus-lifting surgery and the pathogenesis of the disease, to draw conclusions about possible ways to prevent its development.
Results. Odontogenic sinusitis that developed after the sinus-lifting operation is very common in clinical practice, despite the widespread use of this type of bone augmentation and proven methods of surgical intervention. The reason for this can be both anatomical prerequisites and iatrogenic factors, as well as insufficient diagnosis of pathologies of the paranasal sinuses in the preoperative period.
Conclusions. The development of postoperative sinusitis can be avoided with careful planning of the operation, necessarily with computer tomography (preferably, cone-beam (dental) computed tomography, which is characterized by a relatively low load for optimal visualization of the maxillofacial tissues). Pathological changes in the sinus cavity and paranasal structures should be eliminated as planned before the sinus-lifting operation.