bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between fibroblast growth factor 21 with diabetes retinopathy among type 2 diabetes mellitus patients: a systematic review, meta-analysis, and meta-regression
Authors: Basir Herni , Nugrahani Annisa Salsabilla Dwi , Aman Andi Makbul , Bakri Syakib , Rasyid Haerani , Umar Husaini , H. P. Faridin , Ichsan Andi Muhammad , Zainuddin Andi Alfian 
Published: December 2024

Background
Diabetic retinopathy (DR), a leading cause of vision loss worldwide, is a common complication of type 2 diabetes mellitus (T2DM) driven by chronic hyperglycemia and microvascular damage. Fibroblast growth factor 21 (FGF21) is crucial in blood sugar regulation and has been linked to DR incidence and severity. While some studies suggest that FGF21 levels may contribute to the DR incidence, others propose a protective role. This discrepancy necessitates further analysis, prompting this study to evaluate the association between FGF21 levels and DR incidence and severity in T2DM patients.

Methods
A systematic search was conducted through MEDLINE, Web of Science, Scopus, and Embase up to May 2024 for studies evaluating the association between FGF21 and DR incidence and severity. A random-effect model meta-analysis was performed to calculate the pooled standardized mean difference (SMD) and 95% confidence intervals (CI). A univariate meta-regression was performed to analyze factors influencing pooled size estimates. All statistical analyses were performed using STATA 17 software.

Result
This systematic review and meta-analysis of 5,852 participants revealed that FGF21 was positively correlated with DR (SMD 3.11; 95% CI [0.92–5.30], p = 0.005) and sight-threatening DR (STDR) incidence (SMD 3.61; 95% CI [0.82–6.41], p = 0.01). There was no significant difference in FGF21 levels in DR vs STDR (p = 0.79). Subgroup analysis revealed a significant difference in DR incidence between LDL groups, with higher DR incidence in the group with low-density lipoprotein (LDL) levels >100 (P < 0.00001). Meta-regression revealed no variables significantly influenced the pooled size estimates.

Conclusion
A higher level of FGF21 was associated with higher DR and STDR incidence among T2DM patients, highlighting its potential utilization as a biomarker for DR detection and enabling the exploration of FGF21-based treatment strategies. However, variables independently predicting DR among patients with elevated FGF21 levels shall be explored further.

PROSPERO ID
CRD42024559142.
Pepper power: short-term impact of pepper consumption on the gut bacteriome composition in healthy volunteers
Authors: Owolo Oluwafayoke , Audu Haruna J. , Afolayan Ayorinde O. , Ayeni Funmilola A. 
Published: December 2024

Background
Pepper from Capsicum species is a well-established spice with a rich history of culinary use. Some observations have linked its consumption to gastrointestinal discomfort and alterations in stool patterns while it is considered beneficial in some cultures. However, there is lack of information on the direct effect of pepper consumption on human gut microbiota, we conducted dietary intervention studies to assess the impact of pepper on gut bacteriome composition in humans.

Methods
Ten healthy volunteers were recruited, and each person received 200 ml of 0.14 g/ml fresh Habanero Pepper (Capsicum chinense) daily over a 4-day period after which they abstained from pepper consumption for the subsequent 4 days before resumption of their normal diet. Stool samples were collected at baseline, after pepper consumption, after 4 days without pepper and after 4- and 6-days resumption of normal diet. We sequenced the V3-V4 region of the 16S rRNA gene and analyzed microbial diversity and composition using the QIIME2 pipeline and relevant R packages.

Results
Consumption of pepper over a 4-day period led to a higher abundance of Verrucomicrobia, a phylum rarely found in significant proportions at other time points. There was a gradual depletion of Shigella and Staphylococcus spp. from baseline untill the end of the study. Other taxa showed timepoint specific associations, emphasizing the potential impact of short-term dietary interventions on the relative abundance of these genera.

Conclusions
Our study adds nuance to the understanding of diet-microbiota interactions, highlighting the intricate relationship between pepper consumption and gut bacteriome composition. Further exploration of these dynamics holds promise for personalized dietary recommendations and targeted interventions to support gut microbial health.
House I: A practical study on the relationship of “external shape,” “composition,” and “structure” during the design process
Authors: Hojin Hisashi 
Published: December 2019

AbstractThis paper focuses on a house with a workplace for a family of four. The building includes three design elements that play an influential role in architecture: external shape, composition, and structure. I designed the home paying attention to how these components were dealt with throughout the design process and how they would appear in the final product. The correlation of each element is crucial in creating a space where one can experience the dynamic fluctuation of the master‐slave relationship, and we can see the leading part switching for each scene of the space. In this article, I reflect on the design process and examine the way the three elements are handled hierarchically, and those relationships and the significance.
Near‐Unity and Narrowband Thermal Emissivity in Balanced Dielectric Metasurfaces
Authors: Howes Austin , Nolen Joshua R. , Caldwell Joshua D. , Valentine Jason 
Published: December 2019

AbstractNanostructured materials have provided new freedoms for tailoring thermal emissivity in an ultracompact footprint. However, while many designs have demonstrated large absorption amplitude, this often comes at the expense of angular dispersion or the need for a reflective backplane. Furthermore, metal‐based designs generally have broad linewidths due to large nonradiative damping. Here, a unique approach is outlined for obtaining narrowband near‐unity thermal emissivity through spectrally overlapping two orthogonal lossy Mie‐type modes in dielectric metasurfaces operating in the long‐wave infrared. Operating near the transverse optic phonon frequency of a polar dielectric provides a suitably lossy environment, but also one featuring extremely large permittivity, enabling deeply subwavelength resonator sizes, insensitivity to the angle of incidence, and large quality factors even while operating in the long‐wave infrared. Balancing the oscillator strengths and optical losses of the two overlapped resonances maximizes the absorption, resulting in a 3C‐SiC metasurface with 78% absorptance and a quality factor of 170. This balanced metasurface possesses a quality factor on par with some of the narrowest band thermal emitters in the long‐wave infrared, while possessing a simple architecture and prospects for unity emissivity.
Nephronophthisis due to a novel DCDC2 variant in a patient from African‐Caribbean descent: A case report
Authors: Slater Brady , Bekheirnia Nasim , Angelo Joseph , Bi Weimen , Braun Michael C. , Bekheirnia Mir Reza 
Published: December 2019

AbstractNephronophthisis‐19 (NPHP19) due to truncating mutations in the DCDC2 gene has only been described previously in two patients. We describe a new case in a patient from the island country of Saint Vincent and the Grenadines, in the West Indies. This condition is a renal‐hepatic ciliopathy with phenotypic characteristics that include hepatosplenomegaly, hepatic fibrosis with bile cholestasis, increased kidney echogenicity, and end‐stage renal disease.Here, we report a 13‐year‐old African‐Caribbean female with areas of absence of heterozygosity suggesting parental consanguinity or identity by decent due to the founder effect, harboring a novel homozygous pathogenic variant (c.383C>G, p.S128*) in exon 3 of DCDC2. Her phenotype is consistent with the other two known cases of NPHP19, however, this patient also presents psychiatric symptoms. These psychiatric findings were not present in the first two documented cases, and we discuss possible etiologies of these symptoms. Our study presents the first patient from the West Indies with NPHP19, and also highlights the need to investigate the frequency of pathogenic variants within at‐risk populations.
Gemcitabine and bendamustine is a safe and effective salvage regimen for patients with recurrent/refractory Hodgkin lymphoma: Results of a phase 1/2 study
Authors: Cohen Jonathon B. , Wei Lai , Maddocks Kami J. , Christian Beth , Heffner Leonard T. , Langston Amelia A. , Lechowicz Mary Jo , Porcu Pierluigi , Flowers Christopher R. , Devine Steven M. , Blum Kristie A. 
Published: December 2019

BackgroundBoth gemcitabine and bendamustine have been evaluated in patients with recurrent/refractory Hodgkin lymphoma but to the authors' knowledge not as a doublet. The authors completed a phase 1/2 trial to identify the optimal dose and frequency of administration and to assess the efficacy of this combination in patients with recurrent/refractory Hodgkin lymphoma.MethodsPatients were treated up to a maximum dose of gemcitabine (1000 mg/m2 on day 1) and bendamustine (120 mg/m2 on days 1 and 2), which was determined to be the recommended phase 2 dose, administered every 21 days for up to 6 cycles. Patients could discontinue study therapy after 2 cycles to proceed with autologous or allogeneic stem cell transplantation.ResultsNo dose‐limiting toxicities were identified, but 4 patients experienced grade 3 to 5 pulmonary adverse events (toxicity was graded according to Common Terminology Criteria for Adverse Events [version 4]). A total of 26 patients were enrolled having completed a median of 4 prior lines of therapy (range, 1‐7 lines), including 13 patients at the recommended phase 2 dose, in whom the overall response rate was 69% and the complete response rate was 46%. The median progression‐free survival for the phase 2 patients was 11 months (95% CI, 3 months to not reached), and the median overall survival for this group had not been reached at the time of last follow‐up (95% CI, 4 months to not reached).ConclusionsThis doublet was found to be tolerable and effective, but patients must be monitored closely for pulmonary toxicity. The authors currently are evaluating this doublet in combination with nivolumab.
Mapping the TOEFL iBT® Test Scores to China's Standards of English Language Ability: Implications for Score Interpretation and Use
Authors: Papageorgiou Spiros , Wu Sha , Hsieh Ching‐Ni , Tannenbaum Richard J. , Cheng Mengmeng 
Published: December 2019

The past decade has seen an emerging interest in mapping (aligning or linking) test scores to language proficiency levels of external performance scales or frameworks, such as the Common European Framework of Reference (CEFR), as well as locally developed frameworks, such as China's Standards of English Language Ability (CSE). Such alignment is ultimately a claim about the interpretation of test scores in relation to external levels of language proficiency. To support such a claim, established procedures should be carefully implemented and multiple sources of evidence should be collected. In this research report, we demonstrate the application of a series of steps in building an argument for aligning the scores of the TOEFL iBT® test, an international, large‐scale language proficiency test of English as a foreign language (EFL), to the levels of the CSE. The alignment process comprised the following steps: (a) establishing construct congruence between the TOEFL iBT test and the CSE; (b) establishing recommended minimum test scores (cut scores), set by local experts, to classify language learners into the local proficiency levels; (c) collection of scores by test takers (N = 1,326) and evaluations of the test takers' proficiency levels by their teachers, based on the local framework; and (d) consideration of the results of other alignment studies in the local context as well as the link between the CEFR and the CSE levels. We conclude with a discussion of the contextual issues that should be considered when interpreting test scores in relation to external proficiency levels. These contextual issues are important considerations because they have the potential to impact score‐based decisions on individuals and institutions. We also discuss the implications for similar alignment research.
Two effects of GATA2 enhancer repositioning by 3q chromosomal rearrangements
Authors: Suzuki Mikiko , Katayama Saori , Yamamoto Masayuki 
Published: December 2019

AbstractChromosomal inversion and translocation between 3q21 and 3q26 [inv (3)(q21.3q26.2) and t(3;3)(q21.3;q26.2), respectively] give rise to acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), which have poor prognoses. The chromosomal rearrangements reposition a GATA2 distal hematopoietic enhancer from the original 3q21 locus to the EVI1 (also known as MECOM) locus on 3q26. Therefore, the GATA2 enhancer from one of two GATA2 alleles drives EVI1 gene expression in hematopoietic stem and progenitor cells, which promotes the accumulation of abnormal progenitors and induces leukemogenesis. On the other hand, one allele of the GATA2 gene loses its enhancer, which results in reduced GATA2 expression. The GATA2 gene encodes a transcription factor critical for the generation and maintenance of hematopoietic stem and progenitor cells. GATA2 haploinsufficiency has been known to cause immunodeficiency and myeloid leukemia. Notably, reduced GATA2 expression suppresses the differentiation but promotes the proliferation of EVI1‐expressing leukemic cells, which accelerates EVI1‐driven leukemogenesis. A series of studies have shown that the GATA2 enhancer repositioning caused by the chromosomal rearrangements between 3q21 and 3q26 provokes misexpression of both the EVI1 and GATA2 genes and that these two effects coordinately elicit high‐risk leukemia.
Inside Cover: Generalized spectral light scatter models of diverse bacterial colony morphologies (J. Biophotonics 12/2019)
Authors: Doh Iyll‐Joon , Sturgis Jennifer , Sarria Zuniga Diana V. , Pruitt Robert E. , Robinson J. Paul , Bae Euiwon 
Published: December 2019

The forward elastic‐light‐scattering pattern of a bacterial colony reflects its morphological characteristics. Three bacteria genera whose colonies having convex, crateriform, or irregular elevation were investigated to study the correlation between the morphology and the scattering pattern of the colony. The difference in the colony elevation produced distinct shapes of light diffraction in the scattering pattern, resulting circular diffraction rings or scattered light.Further details can be found in the article by Iyll‐Joon Doh, Jennifer Sturgis, Diana V. Sarria Zuniga, et al. (e201900149).
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Inside Cover: Cellular transformations in near‐infrared light‐induced apoptosis in cancer cells revealed by label‐free CARS imaging (J. Biophotonics 12/2019)
Authors: Levchenko Svitlana M. , Kuzmin Andrey N. , Pliss Artem , Ohulchanskyy Tymish Y. , Prasad Paras N. , Qu Junle 
Published: December 2019

CARS microscopy was employed to monitor the reorganization of intracellular lipids and proteins, as well as cellular transformations, after irradiation with near infrared (NIR) light. NIR light was shown to induce apoptosis in HeLa cells in vitro in a dose‐dependent manner. The progression of apoptosis assessed with CARS microscopy is apparently associated with the generation of reactive oxygen species followed by an excessive formation of lipid droplets and their peroxidation.Further details can be found in the article by Svitlana M. Levchenko, Andrey N. Kuzmin, Artem Pliss, et al. (e201900179)
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Artemisinin‐derived dimers and their antimalarial activities
Authors: Yang Peng , Lu MeiLong , Li Ke , Xie Yang 
Published: December 2019

AbstractMalaria is a tropical disease that leads around half a million people to succumb annually. Antimalarial agents such as artemisinin and its derivatives are crucial to malaria treatment; however, the rapid development of drug resistance to clinically used antimalarials is still the major obstacle to effective chemotherapy. To tackle the growing resistance issue, new antimalarial agents are urgently needed. Using artemisinin‐derived dimers as pharmacological scaffolds has demonstrated promising antimalarial activity; therefore, rational design of the dimers may provide valuable therapeutic intervention to treat malaria or even drug‐resistant malaria. This review emphasized two aspects: (a) different linker‐tethered artemisinin‐derived dimers with potential antimalarial activity and (b) the structure‐activity relationships discussed to provide an insight for rational design of dimers with improved efficiency.
A biuret‐derived, MS‐cleavable cross‐linking reagent for protein structural analysis: A proof‐of‐principle study
Authors: Hage Christoph , Iacobucci Claudio , Götze Michael , Sinz Andrea 
Published: December 2019

AbstractChemical cross‐linking combined with mass spectrometry (XL‐MS) and computational modeling has evolved as an alternative method to derive protein 3D structures and to map protein interaction networks. Special focus has been laid recently on the development and application of cross‐linkers that are cleavable by collisional activation as they yield distinct signatures in tandem mass spectra. Building on our experiences with cross‐linkers containing an MS‐labile urea group, we now present the biuret‐based, CID‐MS/MS‐cleavable cross‐linker imidodicarbonyl diimidazole (IDDI) and demonstrate its applicability for protein cross‐linking studies based on the four model peptides angiotensin II, MRFA, substance P, and thymopentin.
Involvement of the rodent prelimbic and medial orbitofrontal cortices in goal‐directed action: A brief review
Authors: Woon Ellen P. , Sequeira Michelle K. , Barbee Britton R. , Gourley Shannon L. 
Published: December 2019

AbstractGoal‐directed action refers to selecting behaviors based on the expectation that they will be reinforced with desirable outcomes. It is typically conceptualized as opposing habit‐based behaviors, which are instead supported by stimulus–response associations and insensitive to consequences. The prelimbic prefrontal cortex (PL) is positioned along the medial wall of the rodent prefrontal cortex. It is indispensable for action–outcome‐driven (goal‐directed) behavior, consolidating action–outcome relationships and linking contextual information with instrumental behavior. In this brief review, we will discuss the growing list of molecular factors involved in PL function. Ventral to the PL is the medial orbitofrontal cortex (mOFC). We will also summarize emerging evidence from rodents (complementing existing literature describing humans) that it too is involved in action–outcome conditioning. We describe experiments using procedures that quantify responding based on reward value, the likelihood of reinforcement, or effort requirements, touching also on experiments assessing food consumption more generally. We synthesize these findings with the argument that the mOFC is essential to goal‐directed action when outcome value information is not immediately observable and must be recalled and inferred.
In a nutshell: prospects and challenges on coatings for edible kernels
Authors: de Azeredo Henriette Monteiro Cordeiro , Otoni Caio Gomide , de Assis Odilio Benedito Garrido , Forato Lucimara Aparecida , Bernardes‐Filho Rubens 
Published: December 2019

AbstractEdible kernels have been popular food items since ancient times. Although in‐shell nuts are naturally protected and relatively shelf stable, convenience demands require their commercialization in shelled form. However, whereas shelled kernels are more convenient, they are more exposed to oxygen, and thus more susceptible to oxidative rancidity and loss of crunchiness, which negatively affect the product acceptability. In this review, we discuss the role of edible coatings in extending stability of edible kernels, which is an opportunity to be better explored by the industry. The discussion also includes the role of antioxidants in the context of active coatings. Finally, future prospects and research challenges are addressed. © 2019 Society of Chemical Industry
Acute airway compromise after recombinant human TSH administration: A case report and review of the literature
Authors: Dowling Eric , Kasperbauer Jan , Morris John , Bayan Semirra 
Published: December 2019

Radioiodine ablation is a commonly utilized treatment for differentiated thyroid carcinoma. Uptake of radioiodine can be enhanced by pretreatment with thyroid hormone withdrawal or administration of recombinant human thyroid‐stimulating hormone (rhTSH). rhTSH is generally well‐tolerated with minimal adverse effects. However, in patients with extensive tumor burden in confined anatomic spaces, rapid enlargement of normal or neoplastic thyroid tissue secondary to rhTSH administration can result in significant compressive effects. In this report, we describe a case of rapid airway deterioration requiring intubation in a patient with involvement of the thyroid cartilage by papillary thyroid carcinoma.Laryngoscope, 122:0000–0000, 2019 Laryngoscope, 130:2725–2727, 2020
A data and text mining pipeline to annotate human mitochondrial variants with functional and clinical information
Authors: Vitale Ornella , Preste Roberto , Palmisano Donato , Attimonelli Marcella 
Published: December 2019

AbstractBackgroundHuman mitochondrial DNA has an important role in the cellular energy production through oxidative phosphorylation. Therefore, this process may be the cause and have an effect on mitochondrial DNA mutability, functional alteration, and disease onset related to a wide range of different clinical expressions and phenotypes. Although a large part of the observed variations is fixed in a population and hence expected to be benign, the estimation of the degree of the pathogenicity of any possible human mitochondrial DNA variant is clinically pivotal.MethodsIn this scenario, the establishment of standard criteria based on functional studies is required. In this context, a “data and text mining” pipeline is proposed here, developed using the programming language R, capable of extracting information regarding mitochondrial DNA functional studies and related clinical assessments from the literature, thus improving the annotation of human mitochondrial variants reported in the HmtVar database.ResultsThe data mining pipeline has produced a list of 1,073 Pubmed IDs (PMIDs) from which the text mining pipeline has retrieved information on 932 human mitochondrial variants regarding experimental validation and clinical features.ConclusionsThe application of the pipeline will contribute to supporting the interpretation of pathogenicity of human mitochondrial variants by facilitating diagnosis to clinicians and researchers faced with this task.