bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Outcomes of Descemet Membrane Endothelial Keratoplasty in Pseudophakic Eyes Compared With Triple-DMEK at 1-Year Follow-up
Authors: Fajardo-Sanchez Julia , de Benito-Llopis Laura 
Published: December 2020

Purpose:
To compare the survival rate 1 year after Descemet membrane endothelial keratoplasty (DMEK) in pseudophakic eyes versus combined phacoemulsification and DMEK (triple-DMEK).

Methods:
Retrospective, interventional, consecutive case series. From all DMEKs performed from January 1, 2017, to June 30, 2018, we selected those performed in pseudophakic eyes (pseudophakic DMEK) and those that underwent triple-DMEK. We compared the survival rate 1 year after surgery between both groups and between the Fuchs endothelial dystrophy (FED) cases in both groups, plus the FED cases versus the pseudophakic bullous keratopathy (PBK) cases in the pseudophakic DMEK group. Second, we compared rebubbling rates and the influence of the use of gas or corneal sutures on rebubbling and dislocation rates.

Results:
A total of 329 eyes were included (218 eyes pseudophakic DMEK and 111 eyes triple-DMEK). The survival rate at 1 year was 79.8% and 90%, respectively (P = 0.03). When only FED cases were included (133 pseudophakic DMEK and 108 triple-DMEK), no significant difference was found (87.9% vs. 90.7%, P = 0.59). Within the pseudophakic DMEK group, the survival rate was higher in FED cases (87.8%) compared with PBK cases (66.6%) (P = 0.0001). Rebubbling rates were 21.1% (pseudophakic DMEK) and 17.1% (triple-DMEK) (P = 0.39). The use of gas versus air or placing corneal sutures did not seem to influence the rebubbling (P = 0.64 and P = 0.13, respectively) or dislocation rates (P = 0.71 and P = 0.53, respectively).

Conclusions:
In the FED cases, performing phacoemulsification before DMEK or doing a combined procedure did not seem to affect the rebubbling or survival rate up to 1 year postoperatively. PBK was associated with a higher failure rate compared with that of FED.
Using Simulation to Facilitate Transition to the Nurse Educator Role
Authors: Fitzwater Julie , McNeill Jeanette , Monsivais Diane , Nunez Franchesca 
Published: December 2020

Background
Nurse clinicians transitioning to the educator role require competency development. Simulation methods may increase knowledge and skill development in nurse educators.

Purpose
The purpose of this review was to examine what is known about using simulation to facilitate transition to the nurse educator role.

Methods
A literature search was completed including simulation methods at any level of fidelity with nurse educators as learners.

Results
Using Meleis' Transitions Theory, the outcomes of reviewed reports demonstrated properties of transitions, facilitators of transitions, and indicators of successful transitions to the nurse educator role. Transition outcomes related to mastery of the role were not evident in the reports.

Conclusions
Simulation learning has the potential to support the nurse educator in role transition and development.
Adverse Childhood Experiences in Women With Overactive Bladder or Interstitial Cystitis/Bladder Pain Syndrome
Authors: Komesu Yuko M. , Petersen Timothy R. , Krantz Tessa E. , Ninivaggio Cara S. , Jeppson Peter C. , Meriwether Kate V. , Dunivan Gena C. 
Published: December 2020

Objective
The aim of the study was to compare the prevalence of adverse childhood experiences (ACEs) in women with overactive bladder (OAB) or interstitial cystitis/bladder pain syndrome (IC/BPS) to age-matched controls.

Methods
This case-control study compared numbers and types of ACEs in women with OAB or IC/BPS compared with controls based on the Center for Disease Control’s Behavioral Risk Factor Surveillance System ACE Module. Participants completed demographic forms, condition-specific symptom questionnaires, and the ACE Module (11 questions summarizing traumatic exposures occurring before the age of 18 years). Cases and controls were compared using χ2 and t tests, significance level P < 0.05.

Results
Three hundred twenty-two women were enrolled from April 2018 to March 2019; OAB = 91 cases and 91 controls, IC/BPS = 70 cases and 70 controls. Overactive bladder group’s mean age was 56 ± 13 years, and IC/BPS was 46 ± 13 years. Compared with controls, OAB and IC/BPS cases differed in race/ethnicity and education (P < 0.02), history of substance abuse (P ≤ 0.03), and median numbers of ACEs (OAB 3, controls 1; IC/BPS 4, controls 2, P < 0.01). Cases had increased odds of having 4 or more ACEs, a parameter known to be associated with poor health and longevity, and increased greater than 2-fold in OAB and greater than 7-fold in IC/BPS. Interstitial cystitis/bladder pain syndrome cases had notably increased odds of exposure to abuse (physical/emotional/sexual) and witnessed domestic violence (all P < 0.01).

Conclusions
Overactive bladder and IC/BPS cases reported increased ACE exposures; more than one-third of OAB and more than IC/BPS cases reported 4 or more ACES, a threshold associated with poor health outcomes. Recognition of increased childhood adversity in OAB and IC/BPS has important treatment and health implications.
Digital proximity tracing app notifications lead to faster quarantine in non-household contacts: results from the Zurich SARS-CoV-2 Cohort Study
Authors: Ballouz Tala , Menges Dominik , Aschmann Helene E , Domenghino Anja , Fehr Jan S , Puhan Milo A , von Wyl Viktor 
Published: December 2020

AbstractBackgroundDigital proximity tracing (DPT) apps may warn exposed individuals faster than manual contact tracing (MCT), leading to earlier interruption of transmission chains through quarantine. However, it is yet unclear whether these apps lead to a reduction in transmissions under real-world conditions. This study aimed at evaluating whether the SwissCovid DPT app is effective in warning close contacts of SARS-CoV-2 infected cases and prompting them to quarantine earlier.MethodsA population-based sample of adult index cases and close contacts identified through MCT and enrolled in the Zurich SARS-CoV-2 Cohort study were surveyed regarding use of the SwissCovid app and SARS-CoV-2 exposure setting. We analyzed ooutcomes related to app effectiveness and adherence (i.e., receipt and uploading of notification codes by index cases; receipt of app warnings and steps taken by close contacts). Furthermore, we performed adjusted time-to-event analyses stratified by exposure setting to estimate the effect of the app on time between relevant exposure and entering quarantine among close contacts.FindingsWe included 393 index cases and 261 close contacts in the analysis. Among index cases using SwissCovid, 88% reported receiving and uploading a notification code in the app to trigger a warning among proximity contacts. Among close contacts using the app, 38% reported receiving an app warning due to the risk exposure. We found that non-household contacts who were notified by the app started quarantine at a median of 2 days after exposure, while those not notified started quarantine at a median of 3 days. In stratified multivariable analyses, app notified contacts had a greater probability of going into quarantine earlier than those without app notification (HR 1·53, 95% CI 1·15-2·03).InterpretationOur study showed that non-household contacts notified by the app started quarantine one day earlier than those not notified by the app. These findings constitute the first evidence that DPT may reach exposed contacts faster than MCT, leading to earlier quarantine and potential interruption of SARS-CoV-2 transmission chains.FundingCantonal Health Directorate Zurich, University of Zurich Foundation and the Swiss Federal Office of Public Health.
Dynamics of a dual SARS-CoV-2 strain co-infection on a prolonged viral shedding COVID-19 case: insights into clinical severity and disease duration
Authors: Pedro Nicole , Silva Cláudio N. , Magalhães Ana C. , Cavadas Bruno , Rocha Ana M. , Moreira Ana C. , Gomes Maria S. , Silva Diogo , Sobrinho-Simões Joana , Ramos Angélica , Cardoso Maria J. , Filipe Rita , Palma Pedro , Ceia Filipa , Silva Susana , Guimarães João T. , Sarmento António , Fernandes Verónica , Pereira Luisa , Tavares Margarida 
Published: December 2020

AbstractObjectivesA few molecularly proven SARS-CoV-2 cases of symptomatic reinfection are currently known worldwide, with a resolved first infection followed by a second infection after a 48 to 142-day intervening period. We report a multiple-component study of a clinically severe and prolonged viral shedding COVID-19 case in a teenager Portuguese female. She had two hospitalisations, a total of 19 RT-PCR tests, mostly positive, and criteria for releasing from home isolation at the end of 97 days.MethodsThe viral genome was sequenced in seven serial samples and in the diagnostic sample from an infected close relative. A human genome-wide array (>900K) was screened on the seven samples, and in vitro culture was conducted on isolates from three late samples.ResultsThe patient had co-infection by two SARS-CoV-2 strains, affiliated in distinct clades and diverging by six variants. The 20A lineage was absolute at the diagnosis (shared with a cohabitating relative), but nine days later the 20B lineage had 3% frequency, and two months later the 20B lineage had 100% frequency. The 900K profiles confirmed the identity of the patient in the serial samples, and allowed us to infer that she had polygenic risk scores for hospitalization and severe respiratory disease within the normal distributions for a Portuguese population cohort.ConclusionsThe early-on dynamic co-infection was the probable cause for the severity of COVID-19 in this otherwise healthy young patient, and for her prolonged SARS-CoV-2 shedding profile.
A topic landscape study for adolescent depression
Authors: Li Tianran , Guo Liang , Wang Xiaoqiang , Decoster Stijn 
Published: December 2020

BackgroundLiterature on adolescent depression is not only rich in content and diverse in form, but also scattered and complex in structure. However, there is no dynamic development analysis and evolution analysis related to the topic. Therefore, this study drew a topic landscape map and predicted the prevalence of topics in the future.MethodsA systematic review was made to collect research publications on adolescent depression and describe the development of this field in the last five decades. We adopted visualization strategy and Herfindahl-Hirschman Index to uncover the latent structure of different topics from literature. The ARIMA model was utilized to predict the prevalence of each topic in the time dimension.ResultsBy using content analysis technique, 21 topics are extracted from 1,595 articles of adolescent depression. These 21 topics were further divided into four hot topics, seven stable topics and ten cold topics based on the results of the ARIMA model. In particular, we predict that “family environment and parenting styles”, “diagnosis, treatment and interventions” and “mental disorder and behavior problems” will receive much attention in the next five years.ConclusionThis paper provides temporal characteristics of each topic. This has an important implication to choose promising research topics for researchers and journal editors.
Development of a novel hybrid alphavirus-SARS-CoV-2 particle for rapid in vitro screening and quantification of neutralization antibodies, viral variants, and antiviral drugs
Authors: Hetrick Brian , He Sijia , Chilin Linda D. , Dabbagh Deemah , Alem Farhang , Narayanan Aarthi , Luchini Alessandra , Li Tuanjie , Liu Xuefeng , Copeland Joshua , Pak Angela , Cunningham Tshaka , Liotta Lance , Petricoin Emanuel F. , Andalibi Ali , Wu Yuntao 
Published: December 2020

SUMMARYTimely development of vaccines and antiviral drugs is critical to control the COVID-19 pandemic 1–6. Current methods for quantifying vaccine-induced neutralizing antibodies involve the use of pseudoviruses, such as the SARS-CoV-2 spike protein (S) pseudotyped lentivirus7–14. However, these pseudoviruses contain structural proteins foreign to SARS-CoV-2, and require days to infect and express reporter genes15. Here we describe the development of a new hybrid alphavirus-SARS-CoV-2 (Ha-CoV-2) particle for rapid and accurate quantification of neutralization antibodies and viral variants. Ha-CoV-2 is a non-replicating SARS-CoV-2 virus-like particle, composed of SARS-CoV-2 structural proteins (S, M, N, and E) and a RNA genome derived from a fast expressing alphavirus vector 16. We demonstrated that Ha-CoV-2 can rapidly and robustly express reporter genes in target cells within 3-6 hours. We further validated Ha-CoV-2 for rapid quantification of neutralization antibodies, viral variants, and antiviral drugs. In addition, as a proof-of-concept, we assembled and compared the relative infectivity of a panel of 10 Ha-CoV-2 variant isolates (D614G, P.1, B.1.1.207, B.1.351, B.1.1.7, B.1.429, B.1.258, B.1.494, B.1.2, B.1.1298), and demonstrated that these variants in general are 2-10 fold more infectious. Furthermore, we quantified the anti-serum from an infected and vaccinated individual; the one dose vaccination with Moderna mRNA-1273 has greatly increased the anti-serum titer for approximately 6 fold. The post-vaccination serum has also demonstrated various neutralizing activities against all 9 variants tested. These results demonstrated that Ha-CoV-2 can be used as a robust platform for rapid quantification of neutralizing antibodies against SARS-CoV-2 and its variants.
Crystal structure of death-associated protein kinase 1 in complex with the dietary compound resveratrol
Authors: Yokoyama Takeshi , Suzuki Ryoya , Mizuguchi Mineyuki 
Published: December 2020

Death-associated protein kinase 1 (DAPK1) is a large multidomain protein with an N-terminal serine/threonine protein kinase domain. DAPK1 is considered to be a promising molecular target for the treatment of Alzheimer's disease (AD). In the present study, the inhibitory potency of resveratrol (RSV), a dietary polyphenol found in red wine, against the catalytic activity of DAPK1 was investigated. Kinetic and fluorescent probe competitive binding analyses revealed that RSV directly inhibited the catalytic activity of DAPK1 by binding to the ATP-binding site. Crystallographic analysis of DAPK1 in complex with RSV revealed that the A-ring of RSV occupied the nucleobase-binding position. Determination of the binding mode provided a structural basis for the design of more potent DAPK1 inhibitors. In conclusion, the data here clearly show that RSV is an ATP-competitive inhibitor of DAPK1, encouraging speculation that RSV may be useful for the development of AD inhibitors.
Investigation of pull-in behavior of circular nanoplate actuator based on the modified couple stress theory
Authors: Lin Ming-Xian , Chen Chao Kuang 
Published: December 2020

Purpose
This paper aims to present a nonclassical circular plate model subjected to hydrostatic pressure and electrostatic actuations by considering the modified couple stress theory and the surface elasticity theory. The pull-in phenomenon and nonlinear behavior of circular nanoplate are investigated.

Design/methodology/approach
The hybrid differential transformation method (DTM) and finite difference method (FDM) are used to approach the model. The DTM was first applied to the equation with respect to the time, and then the FDM was applied with respect to the radius.

Findings
The numerical results were in agreement with the numerical data in the previous literature. The effects of the length scale parameters, surface parameters, thermal stress, residual stress, hydrostatic pressure and electrostatic actuations of the nonclassical circular plate on the pull-in instability are investigated. The parametric study demonstrated that the pull-in behavior of the circular nanoplate was size dependent.

Originality/value
In this study, the results provide a suitable method in a nonclassical circular plate model. The length scale parameter had an obvious effect on the nonlinear behavior of the circular nanoplate.
Social capital, person-organization fit and cynicism: a multi-stage mediation model of turnover intention in public organizations
Authors: Ko Myeong Chul , Campbell Jesse W. 
Published: December 2020

PurposeThe informal dimension of organizational experience can shape performance-relevant employee behavior, including voluntary turnover. The authors develop a multi-stage model of turnover intention relevant to public organizations based on the quality of informal intra-organizational employee ties. Specifically, the authors argue that organizational social capital reduces turnover intention both directly and indirectly via its influence on person-organization fit, organizational cynicism and job satisfaction.Design/methodology/approachThe authors use data from a survey of 946 Korean public sector employees and partial least squares structural equation modeling to test our hypotheses. A number of checks are performed to evaluate the integrity of the data and probe the robustness of the results.FindingsThe authors find that there is a significant link between organizational social capital and turnover intention, but that this relationship is fully mediated by the specified intervening processes. Social capital is associated with increased P-O fit, increased job satisfaction and reduced cynicism. In turn, P-O fit reduces turnover intention both directly and indirectly via increased job satisfaction and reduced cynicism.Originality/valueWhile a number of studies demonstrate the value of organizational social capital, the current study works through the theoretical mechanisms by which social capital is transformed into valued organizational outputs. Some of these are specifically relevant to public organizations. The authors describe the model's practical relevance and suggest research questions that can build upon our findings. The authors also note the study's limitations.
Systematic incident command training and organisational competence
Authors: Lamb Katherine , Farrow Malcolm , Olymbios Costa , Launder David , Greatbatch Ian 
Published: December 2020

PurposeThe study aims to determine if the application of a systematic command training system (Effective Command) could influence the organisational competency profile, through the identification, training and assessment of key behavioural markers.Design/methodology/approachThe Effective Command framework is aligned to UK National Fire Service role-maps and is routinely used in both development and assessment of Fire Officers worldwide. Data from 1,261 formal assessments were analysed and descriptive statistics performed.FindingsStructured analysis of incident command assessment data should inform subsequent training cycles of individuals, organisations and procedures. Key behavioural markers were identified in Level 1 (L1) and Level 2 (L2) commanders which influence assessment outcomes. Reduced competence scores between L1 and L2 officers were recorded, providing a strong argument for a supported development process for L2 officers.Practical implicationsSix key behavioural markers were identified in L1 commanders, all were associated with information comprehension and evaluation, which ultimately impacted the outcomes of formal assessments. This study provides empirical evidence that frequent incident or scenario exposure, coupled with metacognitive understanding of the decision rationale could reverse these weaknesses and turn them into individual strengths. This in-depth analysis of data generated in individuals who pass or fail these assessments should strengthen organisational learning.Originality/valueThe use of a structured command training framework contributes significantly to operational assurance by providing a robust assessment and training methodology, which ensures that organisations can appoint, train and assess their incident commanders.
Trusted Secure Geographic Routing Protocol: outsider attack detection in mobile ad hoc networks by adopting trusted secure geographic routing protocol
Authors: Shajin Francis H. , Rajesh Paulthurai 
Published: December 2020

Purpose
This study aims to evaluate the direct trust value for each node and calculate the trust value of all nodes satisfying the condition and update the trust value and value each trust update interval for a secure and efficient communication between sender and destination node. Hence, a Trusted Secure Geographic Routing Protocol (TSGRP) has been proposed for detecting attackers (presence of the hacker), considering the trust value for a node produced by combining the location trusted information and the direct trusted information.

Design/methodology/approach
Amelioration in the research studies related to mobile ad hoc networks (MANETs) and wireless sensor networks has shown greater concern in the presence of malicious nodes, due to which the delivery percentage in any given network can degrade to a larger extent, and hence make the network less reliable and more vulnerable to security.

Findings
TSGRP has outperformed the conventional protocols for detecting attacks in MANET. TSGRP is establishing a trust-based secure communication between the sender and destination node. The evaluated direct trust value is used after the transmission of route-request and route-reply packets, to evaluate the direct trust value of each node and a secure path is established between the sender and the destination node. The effectiveness of the proposed TSGRP is evaluated through NS-2 simulation.

Originality/value
The simulation results show the delay of the proposed method is 92% less than PRISM approach and the overhead of the proposed TSGRP approach is 61% less than PRISM approach.
Business management in the football industry from a supply chain management perspective
Authors: Memari Zhaleh , Rezaei Pandari Abbas , Ehsani Mohammad , Mahmudi Shokufeh 
Published: December 2020

PurposeTo understand the football industry in its entirety, a supply chain management (SCM) approach is necessary. This includes the study of suppliers, consumers and their collaborations. The purpose of this study was to present a business management model based on supply chain management.Design/methodology/approachData were collected through in-depth interviews with 12 academic and executive football experts. After three steps of open, axial and selective coding based on grounded theory with a paradigmatic approach, the data were analysed, and a football supply chain management (FSCM) was developed. The proposed model includes three managerial components: upstream suppliers, the manufacturing firm, and downstream customers.FindingsThe football industry sector has three parts: upstream suppliers, manufacturing firm/football clubs and downstream customers. We proposed seven parts for the managerial processes of football supply chain management: event/match management, club management, resource and infrastructure management, customer relationship management, supplier relationship management, cash flow management and knowledge and information flow management. This model can be used for configuration, coordination and redesign of business operations as well as the development of models for evaluation of the football supply chain's performance.Originality/valueThe proposed model of a football supply chain management, with the existing literature and theoretical review, created a synergistic outcome. This synergy is presented in the linkage of the players in this chain and interactions between them. This view can improve the management of industry productivity and improve the products quality.