bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age-associated changes in the immune system may influence the response to anti-PD1 therapy in metastatic melanoma patients
Authors: Kasanen Henna , Hernberg Micaela , Mäkelä Siru , Brück Oscar , Juteau Susanna , Kohtamäki Laura , Ilander Mette , Mustjoki Satu , Kreutzman Anna 
Published: February 2020

AbstractAnti-PD1 treatment has improved the survival of metastatic melanoma patients, yet it is unknown which patients benefit from the treatment. In this exploratory study, we aimed to understand the effects of anti-PD1 therapy on the patients’ immune system and discover the characteristics that would result in successful treatment. We collected peripheral blood (PB) samples from 17 immuno-oncology-naïve metastatic melanoma patients before and after 1 and 3 months of anti-PD1 therapy. In addition, matching tumor biopsies at the time of diagnosis were collected for tissue microarray. The complete blood counts, PB immunophenotype, serum cytokine profiles, and tumor-infiltrating lymphocytes were analyzed and correlated with the clinical data. Patients were categorized based on their disease control into responders (complete response, partial response, stable disease > 6 months, N = 11) and non-responders (progressive disease, stable disease ≤ 6 months, N = 6). During therapy, the PB natural killer T (NKT) cell frequency, expression of CD25 and CD45RO on cytotoxic natural killer (NK) cells, and serum CXC chemokine levels were significantly increased in responders. Furthermore, higher age together with age-associated characteristics from PB, lower frequency of PB-naïve CD8+ T cells, and elevated levels of serum MCP-4 and OPG were discovered as baseline predictors of treatment response. We therefore propose that in addition to T cells, anti-PD1 treatment is associated with NK- and NKT-cell population dynamics, and that the age-associated characteristics from PB together with older age may contribute to prolonged PFS in anti-PD1-treated melanoma patients.
Determinants of Farmland Abandonment on the Urban–Rural Fringe
Authors: Zhou Ting , Koomen Eric , Ke Xinli 
Published: February 2020

AbstractChina’s urban explosion has resulted in a substantial loss of agricultural production on the fringes of many cities. Farmland is not only converted into urban uses but also taken out of production because it has lost its value for those who can farm it. This farmland abandonment process has received little research attention. This paper studies the abandonment of farmland around the rapidly urbanizing city of Wuhan and aims to identify its important determinants based on an extensive field survey among local farmers. Around 800 semi-structured field interviews were conducted to capture the parcel and location characteristics, farming practices, and household characteristics. Important parcel-related drivers of land abandonment are lack of family members to work the land and fragmentation of parcels. Spatial characteristics are less important, except for the presence of certain soil types that favour cultivation and designation under the farmland protection policy. The planted crop species and the option to transfer land to other farmers are important farming practices to continue cultivation. Moreover, farmers with a higher farming income and lower education levels are less likely to abandon their farmland. We suggest that land use policies can help in preventing further farmland abandonment by steering urban development away from the most suitable soils for farming and concentrating development to limit the fragmentation of parcels. Strengthening the land market and removing the remaining barriers for farmers to transfer land to colleagues can further help to keep farmland in production.
Cryotherapy for the prevention of weekly paclitaxel-induced peripheral adverse events in breast cancer patients
Authors: Shigematsu Hideo , Hirata Taizo , Nishina Mai , Yasui Daisuke , Ozaki Shinji 
Published: February 2020

Abstract
Purpose
This randomized phase II study was conducted to investigate the efficacy of cryotherapy in preventing peripheral neuropathy and dermatological adverse events in breast cancer patients treated with weekly paclitaxel.

Methods
Patients treated with 12 weekly doses of paclitaxel for breast cancer were randomized (1:1) into a cryotherapy or control group. The primary endpoint was the percentage of patients with a marked decrease in the Functional Assessment of Cancer Therapy-Neurotoxicity (FACT-NTX) score. The secondary endpoints were Patient Neurotoxicity Questionnaire (PNQ), Common Terminology Criteria for Adverse Event (CTCAE) for peripheral neuropathy, and FACT-Taxane score.

Results
Forty-four patients were randomly assigned to the cryotherapy (n = 22) or control groups (n = 22). The percentage of patients with a marked decrease in FACT-NTX scores was significantly lower in the cryotherapy group than in the control group (41 vs. 73%, p = 0.03). The incidence of CTCAE grade ≥ 2 sensory (p = 0.001) and motor peripheral neuropathy (p = 0.01), and PNQ grade D or higher for sensory peripheral neuropathy (p = 0.02), and decrease in the FACT-Taxane score (p = 0.02) were also significantly lower in the cryotherapy group than in the control group. There were no serious side effects associated with cryotherapy.

Conclusion
Cryotherapy is an effective approach for prevention of peripheral neuropathy and dermatological adverse events in breast cancer patients treated with weekly paclitaxel.
Clinical, radiological, and patient-reported outcomes 13 years after pedicle screw fixation with balloon-assisted endplate reduction and cement injection
Authors: De Gendt Erin E. A. , Kuperus Jonneke S. , Foppen Wouter , Oner F. Cumhur , Verlaan Jorrit-Jan 
Published: February 2020

Abstract
Purpose
In management of traumatic thoracolumbar burst fractures, short-segment pedicle screw fixation with balloon-assisted endplate reduction (BAER) and cement injection is a safe, feasible, and effective technique to maintain radiological alignment with minimum spinal segments involved. However, 20% of patients report daily discomfort despite good spinal alignment and fusion after this technique. This study provides clinical, radiological, and patient-reported outcomes after a minimum 13 years of follow-up.

Methods
Eighteen patients were invited at the outpatient clinic for clinical/radiological examinations. The cohort (originally 20 patients) was treated 13–14 years earlier with pedicle screw fixation, BAER, and cement injection for traumatic thoracolumbar burst fractures. Patient-reported outcome measures were obtained at time of examinations. Current data were compared with data obtained at 6 years of follow-up.

Results
Seventeen patients (median age 50; range 32–80) cooperated. No/minimal back pain was reported by 15 patients, and 12 patients returned to their previous heavy labor work. Median visual analog score of health (80%; 50–100%) was similar to results at 6 years (80%; 60–100% p = 0.259). An Oswestry Disability Index score of less than 20% (reflecting minimal disability) was reported by 14 patients, compared with 15 patients at 6 years of follow-up. No significant differences were found in wedge or Cobb angle between the time points. Intravertebral cement resorption was not observed.

Conclusion
Results from this study suggest that, 13 years after pedicle screw fixation with BAER and cement injection for traumatic thoracolumbar burst fractures, functional performance, pain and radiological outcomes of the current cohort were stable or had slightly improved.

Graphic abstract
These slides can be retrieved under Electronic Supplementary Material.
Boron nitride nanotubes as containers for targeted drug delivery of doxorubicin
Authors: Nejad Marjan A. , Umstätter Philipp , Urbassek Herbert M. 
Published: February 2020

AbstractUsing molecular dynamics simulations, the adsorption and diffusion of doxorubicin drug molecules in boron nitride nanotubes are investigated. The interaction between doxorubicin and the nanotube is governed by van der Waals attraction. We find strong adsorption of doxorubicin to the wall for narrow nanotubes (radius of 9 Å). For larger radii (12 and 15 Å), the adsorption energy decreases, while the diffusion coefficient of doxorubicin increases. It does, however, not reach the values of pure water, as adsorption events still hinder the doxorubicin mobility. It is concluded that nanotubes wider than around 4 nm diameter can serve as efficient drug containers for targeted drug delivery of doxorubicin in cancer chemotherapy.
Improved and scalable online learning of spatial concepts and language models with mapping
Authors: Taniguchi Akira , Hagiwara Yoshinobu , Taniguchi Tadahiro , Inamura Tetsunari 
Published: February 2020

AbstractWe propose a novel online learning algorithm, called SpCoSLAM 2.0, for spatial concepts and lexical acquisition with high accuracy and scalability. Previously, we proposed SpCoSLAM as an online learning algorithm based on unsupervised Bayesian probabilistic model that integrates multimodal place categorization, lexical acquisition, and SLAM. However, our original algorithm had limited estimation accuracy owing to the influence of the early stages of learning, and increased computational complexity with added training data. Therefore, we introduce techniques such as fixed-lag rejuvenation to reduce the calculation time while maintaining an accuracy higher than that of the original algorithm. The results show that, in terms of estimation accuracy, the proposed algorithm exceeds the original algorithm and is comparable to batch learning. In addition, the calculation time of the proposed algorithm does not depend on the amount of training data and becomes constant for each step of the scalable algorithm. Our approach will contribute to the realization of long-term spatial language interactions between humans and robots.
The Role of AMPK Activation for Cardioprotection in Doxorubicin-Induced Cardiotoxicity
Authors: Timm Kerstin N. , Tyler Damian J. 
Published: February 2020

AbstractDoxorubicin is a commonly used chemotherapeutic agent for the treatment of a range of cancers, but despite its success in improving cancer survival rates, doxorubicin is cardiotoxic and can lead to congestive heart failure. Therapeutic options for this patient group are limited to standard heart failure medications with the only drug specific for doxorubicin cardiotoxicity to reach FDA approval being dexrazoxane, an iron-chelating agent targeting oxidative stress. However, dexrazoxane has failed to live up to its expectations from preclinical studies while also bringing up concerns about its safety. Despite decades of research, the molecular mechanisms of doxorubicin cardiotoxicity are still poorly understood and oxidative stress is no longer considered to be the sole evil. Mitochondrial impairment, increased apoptosis, dysregulated autophagy and increased fibrosis have also been shown to be crucial players in doxorubicin cardiotoxicity. These cellular processes are all linked by one highly conserved intracellular kinase: adenosine monophosphate–activated protein kinase (AMPK). AMPK regulates mitochondrial biogenesis via PGC1α signalling, increases oxidative mitochondrial metabolism, decreases apoptosis through inhibition of mTOR signalling, increases autophagy through ULK1 and decreases fibrosis through inhibition of TGFβ signalling. AMPK therefore sits at the control point of many mechanisms shown to be involved in doxorubicin cardiotoxicity and cardiac AMPK signalling itself has been shown to be impaired by doxorubicin. In this review, we introduce different agents known to activate AMPK (metformin, statins, resveratrol, thiazolidinediones, AICAR, specific AMPK activators) as well as exercise and dietary restriction, and we discuss the existing evidence for their potential role in cardioprotection from doxorubicin cardiotoxicity.
Explicating ‘Explication’ via Conceptual Spaces
Authors: De Benedetto Matteo 
Published: February 2020

AbstractRecent years have witnessed a revival of interest in the method of explication as a procedure for conceptual engineering in philosophy and in science. In the philosophical literature, there has been a lively debate about the different desiderata that a good explicatum has to satisfy. In comparison, the goal of explicating the concept of explication itself has not been central to the philosophical debate. The main aim of this work is to suggest a way of filling this gap by explicating ‘explication’ by means of conceptual spaces theory. Specifically, I show how different, strictly-conceptual readings of explication desiderata can be made precise as geometrical or topological constraints over the conceptual spaces related to the explicandum and the explicatum. Moreover, I show also how the richness of the geometrical representation of concepts in conceptual spaces theory allows us to achieve more fine-grained readings of explication desiderata, thereby overcoming some alleged limitations of explication as a procedure of conceptual engineering.
In vivo safety assessment of a bio-inspired bone adhesive
Authors: Hulsart-Billström Gry , Stelzl Christina , Procter Philip , Pujari-Palmer Michael , Insley Gerard , Engqvist Håkan , Larsson Sune 
Published: February 2020

AbstractA new class of materials, bone adhesives, could revolutionise the treatment of highly fragmented fractures. We present the first biological safety investigation of a bio-inspired bone adhesive. The formulation was based upon a modified calcium phosphate cement that included the amino acid phosphoserine. This material has recently been described as substantially stronger than other bioresorbable calcium phosphate cements. Four adhesive groups with the active substance (phosphoserine) and two control groups without phosphoserine were selected for in vitro and in vivo biocompatibility testing. The test groups were subject for cell viability assay and subcutaneous implantation in rats that was followed by gene expression analysis and histology assessment after 6 and 12 weeks. All adhesive groups supported the same rate of cell proliferation compared to the α-TCP control and had viability between 45–64% when compared to cell control. There was no evidence of an increased immune response or ectopic bone formation in vivo. To conclude, this bio-inspired bone adhesive has been proven to be safe, in the present study, without any harmful effects on the surrounding soft tissue.
CASEPLUS-SimPat: An Intersectoral Web-Based Case Management System for Multimorbid Dementia Patients
Authors: Steiner Bianca , Zippel-Schultz Bettina , Popa Andrea , Hellrung Nils , Szczesny Stefan , Möller Claudia , Schultz Carsten , Haux Reinhold 
Published: February 2020

AbstractOne main challenge of health care systems in future will be the care and treatment of dementia patients. To their advanced age, dementia patients do not only have limitations in cognition, perception, and articulation, but also suffer from several other diseases (multimorbidity). These patients have sophisticated needs for assistance, care, and treatment relying on different health care sectors. Well-known communication and coordination deficits between sectors are intensified in the case of dementia, to the above described limitations. Coordination processes concerning the transition of patients from hospitals to inpatient or outpatient aftercare pose particularly difficult. To show a possible future direction for improving intersectoral care of dementia patients, we developed the web-based case management system CASEPLUS-SimPat as part of the project SimPat “Securing Integrated Care for Multi-morbid Patients with Dementia using an IT-based Service Concept”. CASEPLUS-SimPat allows health care professionals, hospital employees and general practitioners, to jointly access patient data and exchange information about the treatment of patients. The case management system was implemented in a three-tier architecture with a role-based authorization concept. A portal for relatives complements the system. By providing precise information and e-learning services, caring relatives are integrated into the care process. In a pilot test, CASEPLUS-SimPat shows a good usability. Adapting aspects, such as keywords used to structure entries will make it easier to find required information, and thus will increase usability. Next steps comprise integration of further health care professionals and care facilities as well as real-life testing in terms of feasibility and effectiveness.
Simulating the impact of Belt and Road initiative and other major developments in Myanmar on an ambassador felid, the clouded leopard, Neofelis nebulosa
Authors: Kaszta Żaneta , Cushman Samuel A. , Htun Saw , Naing Hla , Burnham Dawn , Macdonald David W. 
Published: February 2020

Abstract
Context
After decades of political and economic isolation, Myanmar is now the focus of large international investments, particularly from China, which raises questions of how to balance national development with safeguarding the Indo-Burma biodiversity hotspot.

Objective
To evaluate the impact of five major developments in Myanmar on forest ecosystems, using clouded leopard as a focal and umbrella species for wider biodiversity conservation.

Methods
Based on an empirical habitat relationships model, we identified core areas and corridors in Myanmar, and compared them across the development scenarios. We simulated population dynamics and genetic diversity in each scenario using an individual-based, spatially explicit cost-distance population genetics model.

Results
The predicted current clouded leopard population may be larger than the current carrying capacity of the landscape, raising the possibility that the species’ population has not yet equilibrated with recent habitat loss and degradation. All the developments combined resulted in 36% decrease in landscape connectivity and 29% decrease in simulated clouded leopard population size, including substantial reduction in genetic diversity. Each development was predicted to have a negative effect; however, emerging economic zones had disproportionally large impacts (− 24% in connectivity and − 25% in population size), resulting in fragmentation of the largest core areas. Similarly, the Indian Highway and Silk Road caused fragmentation of the largest core habitats, and the Pipeline Railroad significantly decreased connectivity in the main stronghold for clouded leopards.

Conclusions
Spatially-explicit assessments like the one presented here provide quantitative evaluation on development impacts and help optimize the trade-offs between development and conservation. The rapid and increasing development of Myanmar and surrounding Southeast Asian nations pose an enormous threat to the biodiversity of the region. Optimizing the trade-off between development goals and conservation is essential to minimize the effects of rapid land use change on biodiversity.
Using Motivational Interviewing to Improve Parenting Skills and Prevent Problem Behavior During the Transition to Kindergarten
Authors: Stormshak Elizabeth A. , DeGarmo David , Garbacz S. Andrew , McIntyre Laura Lee , Caruthers Allison 
Published: February 2020

AbstractIn this study, we examined the efficacy of a version of the Family Check-Up (FCU) adapted for kindergarten school entry with regard to parenting skills during the transition to school. We also examined whether improvements in parenting skills would mediate improvements in parent- and teacher-rated child behavior problems from kindergarten to second grade. The FCU is a motivational interviewing (MI) intervention designed to engage parents in treatment to improve parenting skills. Participants were parents of 365 children enrolled in one of five elementary schools in the Pacific Northwestern United States. Main and indirect effects were tested with structural equation path modeling using an intent-to-treat approach. The FCU was associated with improved change in parenting skills, and changes in parenting skills, in turn, predicted reductions in child behavior problems. Implications for embedding MI in family-centered interventions at kindergarten school entry are discussed. Trial registration: NCT02289092
Using archetypoid analysis to classify institutions and faculties of economics
Authors: Wohlrabe Klaus , Gralka Sabine 
Published: February 2020

AbstractWe use archetypoid analysis as a new tool to categorize institutions and faculties of economics. The approach identifies typical characteristics of extreme (archetypal) values in a multivariate data set. Each entity under investigation is assigned relative shares of the identified archetypoid, which show the affiliation of the entity to the archetypoid. In contrast to its predecessor, the archetypal analysis, archetypoids always represent actual observed units in the data. The approach therefore allows to classify institutions in a rarely used way. While the method has been recognized in the literature, it is the first time that it is used in higher education research and as in our case for institutions and faculties of economics. Our dataset contains seven bibliometric indicators for 298 top-level institutions obtained from the RePEc database. We identify three archetypoids, which are characterized as the top-, the low- and the medium-performer. We discuss the assignment of shares of the identified archetypoids to the institutions in detail. As a sensitivity analysis we show how the classification changes when for four and five archetypoids are considered.
Researchers publishing monographs are more productive and more local-oriented
Authors: Kulczycki Emanuel , Korytkowski Przemysław 
Published: February 2020

AbstractIn this study, we investigate what share of researchers publish monographs across fields, gender and seniority. We acquired data from the Polish current research information system (POL-on) containing metadata of about 1,031,141 peer-reviewed publications from 67,415 Polish researchers, including 30,185 monographs from 2013 to 2016. The data are aggregated at the researcher level, which allows us to shed new light on publication patterns in all fields. We show that scholars who publish monographs also publish journal articles at the same time. This pattern is observed in all dimensions, i.e. research fields, gender and seniority. However, substantial differences between the fields are observed. Moreover, we show that researchers who publish monographs are also more productive in terms of the number of publications than researchers who did not publish any monographs. This result is independent of the publication counting method, i.e. fractional or whole counting. At the same time, scholars who publish monographs are more local-oriented in terms of the publication channels they choose.