bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expressiveness of SNOMED CT for wound Care – Mapping a Standardised item Set for Leg Ulcers to SNOMED CT
Authors: Hüsers Jens , Przysucha Mareike , Nolte Lisa , Paul Anne , Matysek Philipp , John Swen , Hübner Ursula 
Published: December 2020

Abstract
Background: Chronic health conditions are on the rise and are putting high economic pressure on health systems as they require well-coordinated prevention and treatment. Among chronic conditions, chronic wounds such as cardiovascular leg ulcers have a high prevalence. The interdisciplinary and multiorganisational character of wound care demands interoperable information exchange that can be achieved by using international semantic standards such as SNOMED CT. This study, therefore, aimed to investigate the expressiveness of SNOMED CT in this medical domain, and thereby its clinical usefulness and the potential need for its extension.Methods: In this study, a consented wound care item set, the National Consensus for the Documentation of Leg Wounds (NKDUC), was mapped to the international reference terminology SNOMED CT. In order to derive the relevant items of the wound domain, an information model was developed that served as the foundation for the mapping. The mapping itself was guided by the procedural formalism of ISO TR 12300. As a result, the reliability, equivalence and coverage rate were determined.Results: The developed information model revealed 268 items to be mapped. Conducted by three health care professionals, the mapping resulted in “moderate” reliability (K=0.512). Regarding a symmetric match, the coverage rate of SNOMED CT was 67.2% overall, and 64.3% specifically for wounds. Conclusion: The results show acceptable reliability values. The overall coverage rate shows that two-thirds of the items found a symmetric map, which is a substantial portion of the source item set. As the differences in the coverage rates between different wound care sections demonstrate, some areas, such as “general medical condition” and “wound assessment”, in particular, were covered better than other areas (“wound status”, “diagnostics” and “therapy”). These deficiencies can be mitigated either by post-coordination or the inclusion of new terms in SNOMED CT. In general, this study adds another puzzle piece to the general knowledge about SNOMED CT in terms of its clinical usefulness and its need for further extensions.
Bioremediation of Clay With High Oil Content and Biological Response After Restoration
Authors: Li Xiaokang , Li Jinling , Qu Chengtun , Yu Tao , Du Mingming 
Published: December 2020

Abstract
The clay with high oil content form soil lumps, which is hard for microbes to repair. In this paper, the bioremediation + biostimulation was applied to improve the bioremediation effect of the soil with high oil content, that modified by local cow dung and sandy soil, the ecological toxicity of the soil after restoration was further analyzed. After 53 days of bioremediation, the degradation efficiency with respect to the total petroleum hydrocarbon (TPH) content reached 76.9% ± 2.2%; the soil bacterial content reached 4.9 × 107 CFU/g soil and the results were better than those in the natural attenuation M1group of experimental soils. The relative abundances of petroleum-degrading bacteria added to M5 remained high (Achromobacter 9.44%, Pseudomonas 31.06%, and Acinetobacter 14.11%), and the proportions of some other indigenous bacteria (Alcanivorax and Paenibacillus) also increased. The toxicity of the bioremediated soil was reduced by seed germination and earthworm survival experiments.
Investigation of West Nile Fever Seroprevalence and Associated Risk Factors among Horses in Egypt
Authors: selim Abdelfattah , Megahed Ameer , Kandeel Sahar , Alanazi Abdullah 
Published: December 2020

Abstract
Determination of the seroprevalence and risk factors associated with West Nile Fever (WNF) in horses is essential for adoption of effective prevention strategies. Our objective was therefore to determine the seroprevalence and identify the risk factors associated with West Nile virus (WNV) infection in the most densely horse populated provinces in Egypt. A cross-sectional study was conducted on 930 horses distributed over five provinces in the Nile Delta of Egypt in 2018. The randomly selected horses from geographical studied areas were serologically tested for WNF, and the horses’ information was obtained from owners. Four variables (geographic location, breed, gender, and age) were used for risk analysis. A total of 156 (16.8%) serum samples were serologically positive for WNV. The highest prevalence of WNV infection was between mixed breed (21.5%), male (26.4%) horses with age ≥ 15 years (68.1%). Age showed the highest risk for the infection with WNV (OR = 4.3, 95% CI 3.0 to 6.2). Gender and breed also showed important risk factors for WNF infection in horses (OR = 2.4, 95% CI 1.6 to 3.7; OR = 1.9, 95% CI 1.2 to 2.8, respectively). However, geographic location seems to have no impact on the seroprevalence of WNV infection among horses in the Nile Delta of Egypt. Our findings strongly recommend intensive surveillance and implementation of effective control and prevention strategies against WNF especially in male of mixed breed horses with ages ≥ 15 years.
Nonlinear Relationship between Sleep Duration and Non-suicidal Self-injurious Behaviour among Chinese Adolescents
Authors: Tang Ying , Wan Yuhui , Xu Shaojun , Zhang Shichen , Hao Jiahu , Tao fangbiao 
Published: December 2020

Abstract
Background

Previous researches showed a positive association between short sleep duration and non-suicidal self-injury (NSSI) among adolescents, but few studies have described the effects of oversleeping and weekend catch-up sleep duration on NSSI. The present study aims to explore the nonlinear relationship between sleep duration and NSSI among Chinese adolescents.
Methods

China’s National Adolescent Health Surveillance data from 2014 to 2015 were collected from 15,713 students in four provinces within China. A self-report questionnaire was used to assess sleep duration and 12-month NSSI. Binomial logistic regression models were used to examine the associations of NSSI with sleep duration. The locally estimated scatter plot smoothing (LOESS) method was used to help explore the associations of total NSSI number with sleep duration, and binomial regression analysis was used to help test this relationship.
Results

About 68.5% of adolescents reported sleeping less than 8 h on weeknights while 37.8% slept more than 10 h per night during weekends. The 12-month prevalence rate of NSSI was 29.4%. Compared to the weekend catch-up sleeping for 0–1 hours, those who slept < 0 hours (adjusted Odd Ratio (aOR) = 1.38, 95% Confidence Interval (95% CI): 1.16–1.64) had higher risk of NSSI. Males who reported ≥ 3 hours of weekend catch-up sleep were significantly increased odds of NSSI (aOR = 1.20, 95%CI: 1.01–1.42). Notably, the positive U-shape association was observed between the entire sleep duration and total NSSI number.
Conclusions

The findings reveals that the nonlinear relationship between sleep duration and non-suicidal self-injurious behaviour among Chinese adolescents. Therefore, it is necessary to be vigilant and screen for sleep duration among adolescents in NSSI treatment or prevention.
Bioprospecting Fungal Glycosyl Hydrolases: Multi-locus Phylogenetic Analysis and Enzyme Activity Profiling for Enhanced Biomass Valorization
Authors: Rastogi Meenal , Shrivastava Smriti , Shukla Pratyoosh 
Published: December 2020

Abstract
Lignocelluloses comprise of celluloses and hemicelluloses which can be effectively depolymerized to obtain fermentable sugars using diverse microbial enzymes, for subsequent conversion to various value-added products. Present study reports the bioprospecting of industrially significant microorganisms and their characterization to attain xylanases with high catalytic efficiency. Four potential xylanolytic fungi were identified through distinct primary and secondary screening process of 294 isolates from samples containing plant degrades. Morphological characterization and multigene analysis (ITS rDNA, 18S rDNA, nLSU rDNA, β-tubulin and actin gene) confirmed them Aspergillus niger AUMS56, Aspergillus tubingensis AUMS60, Aspergillus niger AUMS64 and Aspergillus fumigatus AUKEMS24 and their crude xylanase activities through submerged fermentation using corncob were 18.9, 32.29, 30.68 and 15.82 U ml-1, respectively. AUMS60 and AUMS64 have highest catalytic activity of 1429 U g-1 and 1243 U g-1, respectively, all having pH and temperature optima of 6.0 and 60°C respectively, where AUMS60 produced single xylanase (Xyn60; 36 kDa) and AUMS64 secreted 2 probable isozymes (Xyn64A and Xyn64B; 33.4 and 19.8 kDa). Maximum saccharification efficiency of AUMS60 and AUMS64 were 51.1% (13 h) and 52.2% (24 h) showing enhanced catalytic activity with various cations. Present research reports potential xylanases from indigenous fungi, providing opportunity for development of bio-catalysts concoction (novelty established) for enhanced saccharification of complex lignocelluloses finding specific industrial applications for production of value-added components.
Intraperitoneal Bladder Stones Following Transurethral Cystolithotripsy: A Case Report
Authors: Hsiao Yu-Tse , Lien Wan-Ching 
Published: December 2020

Abstract
Background:Bladder stones are common diseases, constituting 5% of urinary stones. However, iatrogenic bladder rupture with intraperitoneal bladder stones is a rare complication after a transurethral cystolithotripsy (TUCL).Case presentation:A 73-year-old male was sent to the emergency department (ED) with presentations of dyspnea and hematuria after receiving a transurethral cystolithotripsy(TUCL) with laser. Upon arrival, his vital signs were relatively stable. An abdominal X-ray showed a radiopaque lesion within the pelvis. Physical examinations showed diffuse abdominal tenderness with muscle guarding. The initial focused assessment of sonography for trauma (FAST) was positive. Computed tomography (CT) revealed bladder rupture with intraperitoneal bladder stones. The patient received conservative supportive care with antibiotics and foley drainage and was discharged 3 weeks later smoothly.Conclusion:For emergency physicians, bladder rupture should be taken into consideration in patients with intraperitoneal bladder stones following TUCL. Computed tomography remains a standard of diagnosis although ultrasonography is a convenient screening tool for ascites.
Magnitude of Surgical Site Infection and its Associated Factors among Patients who Underwent a Surgical Procedure at Debre Tabor General Hospital, Northwest Ethiopia
Authors: Walelign Mequanint Bezie , Demissie Tadesse Wuletaw , Dessalegn Abaynew Honelign 
Published: December 2020

Abstract
Background: Surgical site infections are commonest nosocomial infections and responsible for considerable morbidity and mortality as well as increased hospitalizations and treatment cost related to surgical operations.Objective: The aim of this study was to determine the magnitude and factors associated with surgical site infections at surgical ward of Debre Tabor General Hospital, Northwest Ethiopia.Method: Institution based cross sectional study was conducted on patients who underwent a surgical procedure at Debre Tabor General Hospital in 2020. The sample size was determined using single population proportion formula. Data were entered and analyzed using SPSS version 21 software. Bivariate and multivariate logistic regressions analysis were employed. Odds ratio and its 95% confidence interval were taken to test the association between the dependent and independent variables. P-value of less than 0.05 will be considered as statistically significant. Result: In this study, a total of 191 patients have participated in the study yielding a response rate of 100%. The mean age of the respondents was 2.5 (SD ±0.68) years. The most age group 115(60.2%) resides at the age group greater than 40 years. More than one half(62.3) of the surgical clients were females. Most of the clients were farmers(32.5%) and un able to read and write(41.9) based on the occupation. The magnitude of surgical site infection in this study was found to be 11.5% (95% CI: 7.8%, 15.9%).The factors existance of comorbidity and antibiotic prophylaxis given were found to be significantly assoiated with magnitude of surgical site infection.Conclusion: The magnitude of surgical site infection in this study was high. Proper management of patients with co-morbidity especially those with diabetes mellitus, proper administration of anesthesia and delivering intravenous antimicrobial prophylaxis before surgery as ordered would significantly reduce the incidence of surgical site infection.
Efficacy and Safety of Tocilizumab in Patients with COVID-19 : A Systematic Review and Meta-Analysis.
Authors: Li Zhenlu , Che Qianqiu , Li Mao , Liu Jianping , Du Rao , Yue Chao , Zhang Ling , Li Hongwei , Zhao Liming , Hu Weiming , Lu Huimin , Xiong Junjie 
Published: December 2020

Abstract
Background Tocilizumab (TCZ) is an anti-interleukin-6 antibody that has been used to treat patients with 2019 coronavirus disease (COVID-19). Numerous retrospective studies have shown beneficial treatment efficacy. Several recent randomized clinical trials have questioned the efficacy of TCZ in patients with COVID-19. Therefore, we performed an updated systematic review and meta-analysis to explore the effectiveness and safety of tocilizumab recently used for treating patients with COVID-19. Methods Randomized clinical trials (RCTs) and comparative studies that compared the outcomes between TCZ and standard of care (SOC) were analysed. PubMed, EMBASE, and the Cochrane Library (inception to November 20, 2020) were systematically searched. Primary outcomes included mortality and the rate of requirement for mechanical ventilation (MV). In addition, several subgroup analyses stratified by disease severity, publication type and TCZ administration were performed. Results Three RCTs, twenty-one cohort studies and nine case-control studies including 11,206 patients were finally included. The TCZ group included 2,794 patients (24.93%) and the SOC group included 8,412 patients (75.07%). The mortality rate (>14 days) of the TCZ group, 29.63% (590/1,991), was lower than the SOC group, 41.51% (2,380/5,734) (OR 0.64, 0.57 to 0.73; p <0.00001). However, no significant difference in-14-day mortality rates was observed between the two groups (13.53% vs 22.92%, p = 0.21). Meanwhile, the rate of MV was significantly decreased in the TCZ group compared with the SOC group (OR 0.42, 0.22 to 0.83; p = 0.01). According to the results of the subgroup analysis stratified by disease severity, TCZ only reduced the mortality rate for critical patients with COVID-19 compared with SOC (OR 0.60, 0.52 to 0.71; P < 0.00001), particularly for patients in the intensive care unit (ICU) or patients requiring MV. No statistically significant increase was recognized in the rates of secondary infections or thrombosis between the two groups. Conclusions This systematic review and meta-analysis found that the addition of tocilizumab to the SOC might reduce mortality after 14 days in patients with COVID-19, particularly critical patients requiring MV. More extensive RCTs with longer follow-up periods are needed to validate these findings.
Conventional Suture With Prolonged Timing of Drainage is as Good as Quilting Suture in Preventing Seroma Formation at Pectoral Area After Mastectomy
Authors: Huang Juan , Wang Shouman , Wu Yuhui , Hai Jian , Mao Jie , Dong Xue , XIAO ZHI 
Published: December 2020

Abstract
BackgroundThe aim of this study was to compare conventional suture with prolonged timing of drainage with quilting suture on the formation of seroma at pectoral area after mastectomy (ME) with sentinel lymph nodes biopsy (SLN) or axillary lymph nodes dissection (ALND) for breast cancer.Methods388 consecutive breast cancer patients were retrospectively analyzed and categorized into three group. Patients in group 1 were with quilting suture, group 2 with conventional suture and 13-15 days drainage in situ, and group 3 with conventional suture and 20-22 days drainage. The primary outcome was the incidence of Grade 2 and 3 seroma at anterior pectoral area within one month postoperatively. Cox regression was used for analysis.ResultsThe incidence of Grade 2 and 3 seroma was comparable among groups (9.5% vs. 7.9% vs. 5.3%, p = 0.437), as well as late Grade 2 and 3 seroma among groups (4.3% vs. 2.9% vs. 1.5%, p = 0.412). Old age, high body mass index and hypertension were independently risk factors for Grade 2 and 3 seroma.ConclusionsProlonged timing of drainage to 13-15 days in conventional suture was long enough to decrease the incidence of Grade 2 and 3 seroma as lower as that in quilting suture group at pectoral area within one month after mastectomy.
WITHDRAWN: Improved Physical Fitness Induced by Physiotherapist-led Exercise in Patients With Permanent Atrial Fibrillation Disappears and Health-related Quality of Life Is Impaired After Detraining – A 3 Months Follow-up
Authors: Borland Maria , Bergfeldt Lennart , Cider Åsa , Rosenkvist Agneta , Jakobsson Marika , Olsson Kristin , Lundwall Adam , Andersson Lars , Nordeman Lena 
Published: December 2020

Abstract
Background: Atrial fibrillation negatively impact physical fitness and health-related quality of life in patients. We recently showed that physiotherapist-led exercise-based cardiac rehabilitation improves physical fitness in patients with permanent atrial fibrillation, however little is known about the effect of detraining after finishing an exercise period. The purpose of the study was to examine the impact of 3 months of detraining on physical fitness, physical activity level and health-related quality of life among patients with permanent atrial fibrillation, after ending a randomized comparison of physiotherapist-led exercise-based cardiac rehabilitation versus physical activity on prescription.Methods: Prospective 3-month follow-up study after a randomized multi-centre study. Of the 87 patients completing the intervention study, 80 (92%) participated in the detraining part (22 women; age 74 ± 5 years), 38 from the physiotherapist-led exercise-based cardiac rehabilitation group and 42 from the physical activity on prescription group. All patients were asked to refrain from organised exercise during the 3-months period of detraining. The primary outcome measure was maximal exercise capacity using an exercise tolerance test. Secondary outcomes measures were muscle function, physical activity level, and health-related quality of life using a muscle endurance tests, Short Form-36, and physical activity assessments (questionnaire and accelerometer), as in the intervention study. We used the Mann-Whitney U-test and X2 test to analyse differences between the groups, and Cohen’s d to determine the effect size. A mixed effect model analysis was used to identify predictors of change in physical fitness.Results: Compared to the physical activity on prescription, physiotherapist-led exercise-based cardiac rehabilitation showed a significantly decreased exercise capacity (−9 ± 11 vs. −2 ± 12 W, P < .0001), reduction in shoulder flexion repetitions (−4 ± 8 vs. 2 ± 7 repetitions, P = .001), and reduced health-related quality of life in the Short Form-36 dimension Role Emotional (−13 ± 39 vs. 6 ± 27 points, P = .006). Conclusion: In elderly patients with permanent atrial fibrillation detraining negatively impacted previously achieved improvements from physiotherapist-led exercise-based cardiac rehabilitation in physical fitness and reduce health-related quality of life. The importance of continued exercise is emphasized and should be part of the strategy. Retrospectively registred in ClinicalTrials.gov Identifier: NCT02493400. First posted July 9, 2015
The Association Between Variants in PLA2R and HLA-DQA1 and Renal Outcomes in Patients With Primary Membranous Nephropathy in Western China
Authors: Fan Shulei , Wang Qiuxia , Wang Amanda Y , Zhang Ping , Zhong Xiang , Chen Shasha , Li Guisen , Wang Li , Wang Wei 
Published: December 2020

Abstract
Background：Both Genome-wide associations and our previous study have shown that single nucleotide polymorphisms (SNPs) of M-type phospholipase A2 receptor (PLA2R) and human leukocyte antigen complex class II HLA-DQα-chain 1 (HLA-DQA1) gene were identified to be associated with primary membranous nephropathy (PMN). However, whether these SNPs affect clinical manifestation and renal outcome for PMN patients is poorly defined. Here, we evaluated whether there is an association between these SNPs and clinical manifestations and renal outcomes of PMN in a western Chinese cohort.Methods: Seven SNPs within PLA2R and one SNP in HLA-DQA1 were selected in our study. Clinical data from 314 patients with PMN were collected and the relationship between the genotype and phenotype was evaluated. A total of 186 patients had follow-up data. We assessed the treatment responses and renal outcomes between patients with these gene polymorphisms after a median follow-up of 18.6 months. Results: Eight SNPs were not associated clinical manifestations of PMN patients (Pc<0.05). rs3828323 T allele was marginally significantly associated with hypertension (P=0.008, Pc=0.064, OR=1.821). After treatment for PMN, urea (OR=1.184, 95%CI:1.030-1.361, P=0.017) was a risk factor for non-remission of the disease, eGFR (OR=0.984, 95%CI:0.970-0.998, P=0.028) and albumin (OR=0.922, 95%CI:0.880-0.966, P=0.001) were protective factors for non-remission of the disease. We also identified that PMN patients with CT/TT genotype for rs3828323 achieved higher cumulative survival rate than patients with CC genotype.Conclusions：Rs3828323 may influence hypertension and renal outcome in patients with PMN. Further research is needed to explore the mechanism for this genotype-disease phenotype association.
HLF is&nbsp;a Potential Prognostic Biomarker in Head and Neck Squamous Cell Carcinoma Based on&nbsp;Bioinformatic&nbsp;Analysis&nbsp;and&nbsp;Experimental&nbsp;Validation
Authors: Fang Wei , Wan Di , Chen Jun , Ma Weiqun , Luo Zhen , Yang Xiaoqin 
Published: December 2020

Abstract
BackgroundHead and neck squamous cell carcinoma (HNSCC) is one of the most frequent cancers worldwide, with an increasing incidence. However, the underlying molecular mechanisms of HNSCC are poorly understood.MethodIn this work, 5 original datasets (GSE23558, GSE13601, GSE30784, GSE9844, GSE78060) of Head and neck squamous cell carcinoma (HNSCC) were selected from Gene Expression Omnibus (GEO) database. To identify differentially expressed genes (DEGs) in HNSCC and adjacent tissues. The common DEGs were acquired by Venn diagram. The sensitivity and specificity of HLF were determined by Receiver operating characteristic curves (ROC). Then, In order to further confirm the relationship between HLF and HNSCC patient’s prognosis, the expression and survival analysis of HLF was performed by Gene Expression Profiling Interactive Analysis (GEPIA), Cell culture, reverse transcription polymerase chain reaction (RT-PCR), western blotting and immunohistochemical staining.ResultsSeventeen DEGs were screened from five sets of HNSCC functional gene expression series in GEO datasets. The low expression of HLF was indicated might be correlated with poor prognosis of HNSCC patients based on the bioinformatics analysis. According to the results of Cell culture, RT-PCR, western blotting, immunohistochemical staining, it was confirmed that the low level of HLF expression correlated with poor prognosis of HNSCC patients.ConclusionThe study effectively revealed useful information about the relationship of the low level of HLF expression and HNSCC. In summary, we identified HLF as a potential prognostic biomarker and therapeutic target for HNSCC.