bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advanced Se3P4@C Anode with Exceptional Cycling Life for High Performance Potassium‐Ion Batteries
Authors: Li Bing , He Ziyao , Zhao Jiawei , Liu Wentao , Feng Yangyang , Song Jiangxuan 
Published: January 2020

AbstractPotassium‐ion batteries have attracted increasing attention for next‐generation energy storage systems due to their high energy density and abundance of potassium. However, the lack of suitable anode highly hampers its practical application due to the large ionic radius of K+. Herein, a Se3P4@mesoporous carbon (Se3P4@C) composite is reported as a high‐performance anode for potassium‐ion batteries. The Se3P4@C composite is synthesized through an in situ combination reaction between red phosphorus and Se within a porous carbon matrix. In this way, the nano‐sized Se3P4 is well confined in the porous carbon and thus exhibits a close contact with the carbon matrix. This can significantly improve the conductivity and alleviate the volume change during the cycling process. As a result, the Se3P4@C exhibits a high reversible initial capacity of 1036.8 mAh g−1 at a current density of 50 mA g−1 as well as an excellent cycle performance with a capacity decay of 0.07% per cycle over 300 cycles under 1000 mA g−1. In terms of high specific capacity and stable cycling performance, the Se3P4@C anode is a promising candidate for advanced potassium‐ion batteries.
Layer‐by‐Layer Assembled Oxide Nanoparticle Electrodes with High Transparency, Electrical Conductivity, and Electrochemical Activity by Reducing Organic Linker‐Induced Oxygen Vacancies
Authors: Cho Ikjun , Song Yongkwon , Cheong Sanghyuk , Kim Younghoon , Cho Jinhan 
Published: January 2020

AbstractSolution‐processable transparent conducting oxide (TCO) nanoparticle (NP)–based electrodes are limited by their low electrical conductivity, which originates from the low level of oxygen vacancies within NPs and the contact resistance between neighboring NPs. Additionally, these electrodes suffer from the troublesome trade‐off between electrical conductivity and optical transmittance and the restricted shape of substrates (i.e., only flat substrates). An oxygen‐vacancy‐controlled indium tin oxide (ITO) NP‐based electrode is introduced using carbon‐free molecular linkers with strong chemically reducing properties. Specifically, ITO NPs are layer‐by‐layer assembled with extremely small hydrazine monohydrate linkers composed of two amine groups, followed by thermal annealing. This approach markedly improves the electrical conductivity of ITO NP‐based electrodes by significantly increasing the level of oxygen vacancies and decreasing the interparticle distance (i.e., contact resistance) without sacrificing optical transmittance. The prepared electrodes surpass the optical/electrical performance of TCO NP‐based electrodes reported to date. Additionally, the nanostructured ITO NP films can be applied to more complex geometric substrates beyond flat substrates, and furthermore exhibit a prominent electrochemical activity. This approach can provide an important basis for developing a wide range of highly functional transparent conducting electrodes.
Coupled cluster theory in the condensed phase within the singles‐T density scheme for the environment response
Authors: Caricato Marco 
Published: January 2020

AbstractReliable simulations of molecules in condensed phase require the combination of an accurate quantum mechanical method for the core region, and a realistic model to describe the interaction with the environment. Additionally, this combination should not significantly increase the computational cost of the calculation compared to the corresponding in vacuo case. In this review, we describe the combination of methods based on coupled cluster (CC) theory with polarizable classical models for the environment. We use the polarizable continuum model (PCM) of solvation to discuss the equations, but we also show how the same theoretical framework can be extended to polarizable force fields. The theory is developed within the perturbation theory energy and singles‐T density (PTES) scheme, where the environmental response is computed with the CC single excitation amplitudes as an approximation for the full one‐particle reduced density. The CC‐PTES combination provides the best compromise between accuracy and computational effort for CC calculations in condensed phase, because it includes the response of the environment to the correlation density at the same computational cost of in vacuo CC. We discuss a number of numerical applications for ground and excited state properties, based on the implementation of CC‐PTES with single and double excitations (CCSD‐PTES), which show the reliability and computational efficiency of the method in reproducing experimental or full‐CC data.This article is characterized under:
Electronic Structure Theory > Ab Initio Electronic Structure Methods
Electronic Structure Theory > Combined QM/MM Methods
Software > Quantum Chemistry
Spin Me Right Round Rotational Symmetry for FPGA-Specific AES: Extended Version
Authors: Wegener Felix , De Meyer Lauren , Moradi Amir 
Published: January 2020

AbstractThe effort in reducing the area of AES implementations has largely been focused on application-specific integrated circuits (ASICs) in which a tower field construction leads to a small design of the AES S-box. In contrast, a naive implementation of the AES S-box has been the status-quo on field-programmable gate arrays (FPGAs). A similar discrepancy holds for masking schemes—a well-known side-channel analysis countermeasure—which are commonly optimized to achieve minimal area in ASICs. In this paper, we demonstrate a representation of the AES S-box exploiting rotational symmetry which leads to a 50% reduction in the area footprint on FPGA devices. We present new AES implementations which improve on the state-of-the-art and explore various trade-offs between area and latency. For instance, at the cost of increasing 4.5 times the latency, one of our design variants requires 25% less look-up tables (LUTs) than the smallest known AES on Xilinx FPGAs by Sasdrich and Güneysu at ASAP 2016. We further explore the protection of such implementations against side-channel attacks. We introduce a generic methodology for masking anyn-bit Boolean functions of degreetwith protection orderd. The methodology is exact for first-order and heuristic for higher orders. Its application to our new construction of the AES S-box allows us to improve previous results and introduce the smallest first-order masked AES implementation on Xilinx FPGAs, to date.
In silico MS/MS spectra for identifying unknowns: a critical examination using CFM-ID algorithms and ENTACT mixture samples
Authors: Chao Alex , Al-Ghoul Hussein , McEachran Andrew D. , Balabin Ilya , Transue Tom , Cathey Tommy , Grossman Jarod N. , Singh Randolph R. , Ulrich Elin M. , Williams Antony J. , Sobus Jon R. 
Published: January 2020

AbstractHigh-resolution mass spectrometry (HRMS) enables rapid chemical annotation via accurate mass measurements and matching of experimentally derived spectra with reference spectra. Reference libraries are generated from chemical standards and are therefore limited in size relative to known chemical space. To address this limitation, in silico spectra (i.e., MS/MS or MS2 spectra), predicted via Competitive Fragmentation Modeling-ID (CFM-ID) algorithms, were generated for compounds within the U.S. Environmental Protection Agency’s (EPA) Distributed Structure-Searchable Toxicity (DSSTox) database (totaling, at the time of analysis, ~ 765,000 substances). Experimental spectra from EPA’s Non-Targeted Analysis Collaborative Trial (ENTACT) mixtures (n = 10) were then used to evaluate the performance of the in silico spectra. Overall, MS2 spectra were acquired for 377 unique compounds from the ENTACT mixtures. Approximately 53% of these compounds were correctly identified using a commercial reference library, whereas up to 50% were correctly identified as the top hit using the in silico library. Together, the reference and in silico libraries were able to correctly identify 73% of the 377 ENTACT substances. When using the in silico spectra for candidate filtering, an examination of binary classifiers showed a true positive rate (TPR) of 0.90 associated with false positive rates (FPRs) of 0.10 to 0.85, depending on the sample and method of candidate filtering. Taken together, these findings show the abilities of in silico spectra to correctly identify true positives in complex samples (at rates comparable to those observed with reference spectra), and efficiently filter large numbers of potential false positives from further consideration.
Regulatory systems for gene expression control in cyanobacteria
Authors: Till Petra , Toepel Jörg , Bühler Bruno , Mach Robert L. , Mach-Aigner Astrid R. 
Published: January 2020

AbstractAs photosynthetic microbes, cyanobacteria are attractive hosts for the production of high-value molecules from CO2 and light. Strategies for genetic engineering and tightly controlled gene expression are essential for the biotechnological application of these organisms. Numerous heterologous or native promoter systems were used for constitutive and inducible expression, yet many of them suffer either from leakiness or from a low expression output. Anyway, in recent years, existing systems have been improved and new promoters have been discovered or engineered for cyanobacteria. Moreover, alternative tools and strategies for expression control such as riboswitches, riboregulators or genetic circuits have been developed. In this mini-review, we provide a broad overview on the different tools and approaches for the regulation of gene expression in cyanobacteria and explain their advantages and disadvantages.
New targets for therapy: antigen identification in adults with B-cell acute lymphoblastic leukaemia
Authors: Jordaens Stephanie , Cooksey Leah , Freire Boullosa Laurie , Van Tendeloo Viggo , Smits Evelien , Mills Ken I. , Orchard Kim H. , Guinn Barbara-ann 
Published: January 2020

AbstractAcute lymphoblastic leukaemia (ALL) in adults is a rare and difficult-to-treat cancer that is characterised by excess lymphoblasts in the bone marrow. Although many patients achieve remission with chemotherapy, relapse rates are high and the associated impact on survival devastating. Most patients receive chemotherapy and for those whose overall fitness supports it, the most effective treatment to date is allogeneic stem cell transplant that can improve overall survival rates in part due to a ‘graft-versus-leukaemia’ effect. However, due to the rarity of this disease, and the availability of mature B-cell antigens on the cell surface, few new cancer antigens have been identified in adult B-ALL that could act as targets to remove residual disease in first remission or provide alternative targets for escape variants if and when current immunotherapy strategies fail. We have used RT-PCR analysis, literature searches, antibody-specific profiling and gene expression microarray analysis to identify and prioritise antigens as novel targets for the treatment of adult B-ALL.
Appropriate Source Control and Antifungal Therapy are Associated with Improved Survival in Critically Ill Surgical Patients with Intra‐abdominal Candidiasis
Authors: Yan Ting , Li Shuang‐Ling , Ou Hai‐Li , Zhu Sai‐Nan , Huang Lei , Wang Dong‐Xin 
Published: January 2020

AbstractBackgroundIntra‐abdominal candidiasis (IAC) is the predominant type of invasive candidiasis with high mortality in surgical intensive care patients. The purpose of this study was to investigate the impact of appropriate source control and antifungal therapy on the outcomes of critically ill surgical patients with IAC.MethodsThis was a retrospective single‐center cohort study. Adult surgical patients who were admitted to the intensive care unit and diagnosed with IAC from January 1, 2003, to December 31, 2016, were enrolled. The patients’ data including risk factors of IAC, infection‐related information, antifungal treatment and 30‐day outcomes were collected. The primary endpoint was 30‐day mortality. A COX proportional hazards model was used to analyze the association between appropriate treatment and 30‐day survival.ResultsA total of 82 patients were included in the analysis. Of these, 45 (54.9%) were complicated with septic shock at IAC diagnosis. Types of IAC included peritonitis (61.0%), intra‐abdominal abscesses (23.2%) and biliary tract infections (15.9%). Of the included patients, 53 (64.6%) received appropriate source control and 44 (53.7%) appropriate antifungal therapy. Compared with patients with neither of these treatments, appropriate source control (HR 0.08, 95% CI 0.02–0.30; P < 0.001), appropriate antifungal therapy (HR 0.14, 95% CI 0.04–0.55; P = 0.005), and a combination of these treatments (HR 0.02, 95% CI 0.00–0.08; P < 0.001) were associated with reduced risk of death within 30 days after IAC diagnosis.ConclusionFor critically ill surgical patients with IAC, both appropriate source control and appropriate antifungal therapy were associated with reduced risk of 30‐day mortality, and the protective effects of the two appropriate treatments were additive.
Mosquito counting system based on optical sensing
Authors: Wang Jinlei , Zhu Shiming , Lin Yueyu , Svanberg Sune , Zhao Guangyu 
Published: January 2020

AbstractMosquitos, sometimes carrying deadly diseases such as malaria, zika, and dengue fever, cause much concern. To control mosquitos, it is important to effectively monitor their presence and behavioral trends. We have constructed two optical sensing systems for insects based on light attenuation and light backscattering, respectively. The systems, which were tested with the potentially dangerousAedes albopictusandCulex pipiens,were able to extract the wing-beat frequency, when they passed impinging light, derived from light-emitting diodes. We could achieve distinction between the sexes ofA. albopictusandC. pipiensbased on the wing-beat frequency. Finally, we propose a statistical method suitable for the system to improve the accuracy of counting.
Neuro-SERKET: Development of Integrative Cognitive System Through the Composition of Deep Probabilistic Generative Models
Authors: Taniguchi Tadahiro , Nakamura Tomoaki , Suzuki Masahiro , Kuniyasu Ryo , Hayashi Kaede , Taniguchi Akira , Horii Takato , Nagai Takayuki 
Published: January 2020

AbstractThis paper describes a framework for the development of an integrative cognitive system based on probabilistic generative models (PGMs) called Neuro-SERKET. Neuro-SERKET is an extension of SERKET, which can compose elemental PGMs developed in a distributed manner and provide a scheme that allows the composed PGMs to learn throughout the system in an unsupervised way. In addition to the head-to-tail connection supported by SERKET, Neuro-SERKET supports tail-to-tail and head-to-head connections, as well as neural network-based modules, i.e., deep generative models. As an example of a Neuro-SERKET application, an integrative model was developed by composing a variational autoencoder (VAE), a Gaussian mixture model (GMM), latent Dirichlet allocation (LDA), and automatic speech recognition (ASR). The model is called VAE + GMM + LDA + ASR. The performance of VAE + GMM + LDA + ASR and the validity of Neuro-SERKET were demonstrated through a multimodal categorization task using image data and a speech signal of numerical digits.
Besov Spaces Induced by Doubling Weights
Authors: Reijonen Atte 
Published: January 2020

AbstractLet $$1\leqslant p<\infty $$

1
⩽
p
<
∞

, $$0<q<\infty $$

0
<
q
<
∞

, and $$\nu $$
ν
be a two-sided doubling weight satisfying $$\begin{aligned} \sup _{0\leqslant r<1}\frac{(1-r)^q}{\int _r^1\nu (t)\,dt}\int _0^r\frac{\nu (s)}{(1-s)^q}\,ds<\infty . \end{aligned}$$

sup

0
⩽
r
<
1

(
1
-
r
)

q

∫
r
1

ν

(
t
)

d
t

∫
0
r

ν
(
s
)

(
1
-
s
)

q

d
s
<
∞
.

The weighted Besov space $$\mathcal {B}_{\nu }^{p,q}$$

B

ν

p
,
q

consists of those $$f\in H^p$$

f
∈

H
p

such that $$\begin{aligned} \int _0^1 \left( \int _{0}^{2\pi } |f'(re^{i\theta })|^p\,d\theta \right) ^{q/p}\nu (r)\,dr<\infty . \end{aligned}$$

∫
0
1

∫

0

2
π

|

f
′

(
r

e

i
θ

)

|

p

d
θ

q
/
p

ν

(
r
)

d
r
<
∞
.

Our main result gives a characterization for $$f\in \mathcal {B}_{\nu }^{p,q}$$

f
∈

B

ν

p
,
q

depending only on |f|, p, q, and $$\nu $$
ν
. As a consequence of the main result and inner-outer factorization, we obtain several interesting by-products. For instance, we show the following modification of a classical factorization by F. and R. Nevanlinna: If $$f\in \mathcal {B}_{\nu }^{p,q}$$

f
∈

B

ν

p
,
q

, then there exist $$f_1,f_2\in \mathcal {B}_{\nu }^{p,q} \cap H^\infty $$

f
1

,

f
2

∈

B

ν

p
,
q

∩

H
∞

such that $$f=f_1/f_2$$

f
=

f
1

/

f
2

. Moreover, we give a sufficient and necessary condition guaranteeing that the product of $$f\in H^p$$

f
∈

H
p

and an inner function belongs to $$\mathcal {B}_{\nu }^{p,q}$$

B

ν

p
,
q

. Applying this result, we make some observations on zero sets of $$\mathcal {B}_{\nu }^{p,p}$$

B

ν

p
,
p

.
Is debridement beneficial for focal cartilage defects of the knee: data from the German Cartilage Registry (KnorpelRegister DGOU)
Authors: Weißenberger Manuel , Heinz Tizian , Boelch Sebastian P. , Niemeyer Philipp , Rudert Maximilian , Barthel Thomas , Reppenhagen Stephan 
Published: January 2020

AbstractIntroductionFocal cartilage defects of the knee are often treated with arthroscopic debridement. Existing literature discussing the benefit of debridement for small articular cartilage lesions is scarce, especially if the debridement was not part of a combined operative cartilage procedure including meniscal and ligament repair. The purpose of this study was to examine the patients´ benefit after arthroscopic debridement for the treatment of isolated focal chondral defects with or without partial meniscus resection.Materials and methodsBaseline (preoperative data) and 12-month follow-up of the five Knee Osteoarthritis Outcome Score (KOOS) subscores and the Numeric Rating Scale (NRS) for pain were analyzed in 126 patients undergoing debridement for focal chondral defects of the knee from the German Cartilage Registry. Sub-analysis for patients receiving isolated debridement and debridement with concomitant partial resection of meniscal pathologies was performed. Thus, four subgroups were created according to the treated defect size and presence of meniscal pathologies: “debridement-only < 2 cm2”, “debridement-only > 2 cm2”, “debridement and partial meniscus resection < 2 cm2” and “debridement and partial meniscus resection > 2 cm2”.ResultsKOOS-subscores showed a significant increase from baseline to follow-up evaluation (p = 0.017–0.037) within the 126 patients. Sub-analysis showed significant improvement of all five KOOS-subscores in all three subgroups, except for the “debridement and partial meniscus resection > 2 cm2”—group: in this group the KOOS subscores symptoms and sports showed no significant improvement. The NRS scores revealed no significant changes from baseline to 12-month follow-up within the four subgroups.ConclusionAn overall benefit of arthroscopic debridement for focal cartilage lesions of the knee could be conducted. Isolated cartilage defects seem to benefit from debridement irrespectively of size. In patients with large cartilage defects (> 2 cm2) and concurrent meniscal pathology expectation to improvement should be humbled. Effective reduction of pain by arthroscopic debridement remains unclear.
The impact of p16ink4a positivity in invasive vulvar cancer on disease-free and disease-specific survival, a retrospective study
Authors: Gensthaler Lisa , Joura Elmar A. , Alemany Laia , Horvat Reinhard , de Sanjosé Silvia , Pils Sophie 
Published: January 2020

Abstract
Purpose
To evaluate HPV and p16ink4a status as prognostic factors in patients with invasive vulvar cancer.

Methods
Retrospective analysis of disease-free (DFS) and disease-specific survival (DSS) of patients with invasive vulvar cancer at a single tertiary care center. Histology, HPV and p16ink4a status were evaluated in the context of a global multicenter trial. Logistic regression models were performed to identify the impact of p16ink4a positivity.

Results
135 patients were included in the analysis. 32 (23.7%) showed a p16ink4a expression of over 25%. Disease-free and disease-specific survival was longer in p16ink4a positive patients (23 vs. 10 months, p = 0.004, respectively, 29 vs. 21 months, p = 0.016). In multivariate analysis, p16ink4a positivity was an independent parameter for DFS (p = 0.025, HR: 2.120 (1.100–4.085)), but not for DSS (p = 0.926, HR: 1.029 (0.558–1.901), in contrast to age and tumor stage.

Conclusions
Age and tumor stage negatively affect survival. However, disease-free survival is significantly longer in patients with p16ink4a positive invasive vulvar cancer.
The association of HFE gene H63D polymorphism with endurance athlete status and aerobic capacity: novel findings and a meta-analysis
Authors: Semenova Ekaterina A. , Miyamoto-Mikami Eri , Akimov Egor B. , Al-Khelaifi Fatima , Murakami Haruka , Zempo Hirofumi , Kostryukova Elena S. , Kulemin Nikolay A. , Larin Andrey K. , Borisov Oleg V. , Miyachi Motohiko , Popov Daniil V. , Boulygina Eugenia A. , Takaragawa Mizuki , Kumagai Hiroshi , Naito Hisashi , Pushkarev Vladimir P. , Dyatlov Dmitry A. , Lekontsev Eugene V. , Pushkareva Yuliya E. , Andryushchenko Liliya B. , Elrayess Mohamed A. , Generozov Edward V. , Fuku Noriyuki , Ahmetov Ildus I. 
Published: January 2020

Abstract
Purpose
Iron is an important component of the oxygen-binding proteins and may be critical to optimal athletic performance. Previous studies have suggested that the G allele of C/G rare variant (rs1799945), which causes H63D amino acid replacement, in the HFE is associated with elevated iron indexes and may give some advantage in endurance-oriented sports. The aim of the present study was to investigate the association between the HFE H63D polymorphism and elite endurance athlete status in Japanese and Russian populations, aerobic capacity and to perform a meta-analysis using current findings and three previous studies.

Methods
The study involved 315 international-level endurance athletes (255 Russian and 60 Japanese) and 809 healthy controls (405 Russian and 404 Japanese). Genotyping was performed using micro-array analysis or by PCR. VO2max in 46 male Russian endurance athletes was determined using gas analysis system.

Results
The frequency of the iron-increasing CG/GG genotypes was significantly higher in Russian (38.0 vs 24.9%; OR 1.85, P = 0.0003) and Japanese (13.3 vs 5.0%; OR 2.95, P = 0.011) endurance athletes compared to ethnically matched controls. The meta-analysis using five cohorts (two French, Japanese, Spanish, and Russian; 586 athletes and 1416 controls) showed significant prevalence of the CG/GG genotypes in endurance athletes compared to controls (OR 1.96, 95% CI 1.58–2.45; P = 1.7 × 10–9). Furthermore, the HFE G allele was associated with high V̇O2max in male athletes [CC: 61.8 (6.1), CG/GG: 66.3 (7.8) ml/min/kg; P = 0.036].

Conclusions
We have shown that the HFE H63D polymorphism is strongly associated with elite endurance athlete status, regardless ethnicities and aerobic capacity in Russian athletes.