bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discovery of Biomarkers in Hepatocellular Carcinoma Metastasis Using Bioinformatic Analysis
Authors: Wei Jinrui , Ur Rashid Haroon , Wu Lichuan 
Published: July 2020

Background:
Liver cancer is one of the most deadly malignancies worldwide. Tumor
metastasis is the main cause of liver cancer-related death. So far, the mechanism of liver cancer
metastasis is far away from fully elucidated. In this study, we aimed to discover key regulators
involved in liver cancer metastasis by data mining.

Methods:
Two different types of data, including mRNA microarray (GSE6222 and GSE6764) and
miRNA microarray (GSE67138), were analyzed. A total of 83 intersectant differently expressed
genes (DEGs) with the same expression pattern in GSE6222 and GSE6764 were identified. One
hundred and thirty-one differently expressed miRNAs (DEMs) were identified in GSE 67138.
Furthermore, a total of 26 pairs of miRNA-target, including 18 DEMs and 13 DEGs were identified
as critical miRNA-target axis via miRNA-target gene interaction analysis.

Result and Conclusion:
Among the 18 DEMs and 13 DEGs, 10 miRNAs and 10 target
genes are significantly correlated with patients’ survival (p<0.05). Our results and methods might be
interesting for data mining and helpful for further experimental functional validation.
Poly (Adenine) Modified Graphene-Based Voltammetric Sensor for the Electrochemical Determination of Catechol, Hydroquinone and Resorcinol
Authors: Manjunatha Jamballi G. 
Published: July 2020

Objective:
This paper presents the application of Poly (Adenine) Modified Graphene Paste Electrode (PAMGPE) for the analysis of Catechol (CC) with Resorcinol (RC) and Hydroquinone (HQ) by a voltammetric technique.

Methods:
Electropolymerization technique was utilized for the modification of the sensor surface. The electrode surface was characterized by Field Emission Scanning Electron Microscopy (FE-SEM). Cyclic Voltammetry (CV) and Differential Pulse Voltammetry (DPV) were used to study the redox behavior of CC, RC and HQ.

Results:
Oxidation peak current of CC increased linearly with the concentration of CC in the range from 2×10-6- 8×10-6 M and 1×10-5-1.5 ×10-4 M with a detection limit of 2.4×10-7 M. The practical application of the developed sensor was verified as exact for the determination of CC in water sample.

Conclusion:
The stability, repeatability, and reproducibility of the developed electrode were studied and established good characteristics. Furthermore, the PAMGPE was examined for the simultaneous determination of CC, RC and HQ.
Mandelic Acid: An Efficient Organo-catalyst for the Synthesis of 3-substituted-3- Hydroxy-indolin-2-ones and Related Derivatives in Aqueous Ethanol at Room Temperature
Authors: Kaur Gurpreet , Kumar Rajat , Saroch Shivam , Gupta Vivek Kumar , Banerjee Bubun 
Published: July 2020

Background:
Indoles and various indolyl derivatives are very common in naturally occurring
biologically active compounds. Many methods are being developed for the synthesis of various
bioactive indole derivatives.

Objective:
Synthesis of biologically promising structurally diverse indole derivatives under mild and
environmentally benign conditions.

Methods:
Synthesis of 3-hydroxy-3-(5-(trifluoromethoxy)-1H-indol-3-yl)indolin-2-one was achieved
by the reaction of an equimolar mixture of isatin and 3-(trifluoromethoxy)-1H-indol using 20 mol% of
mandelic acid as catalyst in aqueous ethanol at room temperature. Under the same optimized reaction
conditions, synthesis of 3-(3-hydroxy-2-oxoindolin-3-yl)chroman-2,4-diones was accomplished via the
reactions of substituted isatins and 4-hydroxycoumarin. On the other hand, 2-hydroxy-2-(indol-3-yl)-
indene-1,3-diones and 10-hydroxy-10-(5-methoxy-1H-indol-3- yl)phenanthren-9(10H)-one were synthesized
from the reactions of indoles and ninhydrin or 9,10-phenanthrenequinone respectively using
the same 20 mol% of mandelic acid as an efficient organo-catalyst in aqueous ethanol at room temperature.

Results:
Mild, safe and clean reaction profiles, energy efficiency, high atom-economy, use of naturally
occurring non-toxic organo-catalyst, easy isolation procedure by avoiding column chromatographic
purification and gram scale production are some the major advantages of this developed protocol.

Conclusion:
A simple, straightforward and eco-friendly protocol has been developed for the efficient
synthesis of biologically promising novel 3-hydroxy-3-(5-(trifluoromethoxy)-1H-indol- 3-yl)indolin-2-
one, 3-(3-hydroxy-2-oxoindolin-3-yl)chroman-2,4-diones, 2-hydroxy-2-(indol-3- yl)-indene-1,3-diones
and 10-hydroxy-10-(5-methoxy-1H-indol-3-yl)phenanthren-9(10H)-one using a catalytic amount of
mandelic acid in aqueous ethanol at room temperature.
A Federated Online Search Tool for Biospecimens (Sample Locator): Usability Study
Authors: Schüttler Christina , Huth Verena , von Jagwitz-Biegnitz Magdaléna , Lablans Martin , Prokosch Hans-Ulrich , Griebel Lena 
Published: July 2020

Background
The German Biobank Alliance (GBA) aims to establish a cross-site biobank network. For this endeavor, the so-called Sample Locator, a federated search tool for biospecimens and related data, has been developed, forming the heart of its information technology (IT) infrastructure.

Objective
To ensure the sustainable use of such a tool, we included researchers as participants in an end user–based usability evaluation.

Methods
To develop a prototype ready for evaluation, we needed input from GBA IT experts. Thus, we conducted a 2-day workshop with 8 GBA IT team members. The focus was on the respective steps of a user-centered design process. With the acquired knowledge, the participants designed low-fidelity mock-ups. The main ideas of these mock-ups were discussed, extracted, and summarized into a comprehensive prototype using Microsoft PowerPoint. Furthermore, we created a questionnaire concerning the usability of the prototype, including the System Usability Scale (SUS), questions on negative and positive aspects, and typical tasks to be fulfilled with the tool. Subsequently, the prototype was pretested on the basis of this questionnaire with researchers who have a biobank background. Based on this preliminary work, the usability analysis was ultimately carried out with researchers and the results were evaluated.

Results
Altogether, 27 researchers familiar with sample requests evaluated the prototype. The analysis of the feedback certified a good usability, given that the Sample Locator prototype was seen as intuitive and user-friendly by 74% (20/27) of the participants. The total SUS score by the 25 persons that completed the questionnaire was 80.4, indicating good system usability. Still, the evaluation provided useful advice on optimization potential (eg, offering a help function).

Conclusions
The findings of this usability analysis indicate that the considerations regarding a user-friendly application that have been made in the development process so far strongly coincide with the perception of the study participants. Nevertheless, it was important to engage prospective end users to ensure that the previous development is going in the desired direction and that the Sample Locator will be used in the future. The user comments and suggestions for improvement will be considered in upcoming iterations for refinement.
Optimizing Antibiotic Prescribing for Acute Respiratory Tract Infection in German Primary Care: Study Protocol for Evaluation of the RESIST Program
Authors: Löffler Christin , Krüger Antje , Daubmann Anne , Iwen Julia , Biedermann Marc , Schulz Maike , Wegscheider Karl , Altiner Attila , Feldmeier Gregor , Wollny Anja 
Published: July 2020

Background
The emergence and increased spread of microbial resistance is a major challenge to all health care systems worldwide. In primary care, acute respiratory tract infection (ARTI) is the health condition most strongly related to antibiotic overuse.

Objective
The RESIST program aims at optimizing antibiotic prescribing for ARTI in German primary care. By completing a problem-orientated online training course, physicians are motivated and empowered to utilize patient-centered doctor-patient communication strategies, including shared decision making, in the treatment of patients with ARTI.

Methods
RESIST will be evaluated in the form of a nonrandomized controlled trial. Approximately 3000 physicians of 8 (out of 16) German federal states can participate in the program. Patient and physician data are retrieved from routine health care data. Physicians not participating in the program serve as controls, either among the 8 participating regional Associations of Statutory Health Insurance Physicians (control group 1) or among the remaining associations not participating in RESIST (control group 2). Antibiotic prescription rates before the intervention (T0: 2016, 1st and 2nd quarters of 2017) and after the intervention (T1: 3rd quarter of 2017 until 1st quarter of 2019) will be compared. The primary outcome measure is the overall antibiotic prescription rate for all patients insured with German statutory health insurance before and after provision of the online course. The secondary outcome is the antibiotic prescription rate for coded ARTI before and after the intervention.

Results
RESIST is publicly funded by the Innovations funds of the Federal Joint Committee in Germany and was approved in December 2016. Recruitment of physicians is now completed, and a total of 2460 physicians participated in the intervention. Data analysis started in February 2020.

Conclusions
With approximately 3000 physicians participating in the program, RESIST is among the largest real-world interventions aiming at reducing inadequate antibiotic prescribing for ARTI in primary care. Long-term follow up of up to 21 months will allow for investigating the sustainability of the intervention.

Trial Registration
ISRCTN Registry ISRCTN13934505; http://www.isrctn.com/ISRCTN13934505

International Registered Report Identifier (IRRID)
RR1-10.2196/18648
COVID-19 Outbreak and Management Approach for Families with Children on Long-Term Kidney Replacement Therapy
Authors: Zhao Rui , Zhou Qing , Wang Xiao-Wen , Liu Cui-Hua , Wang Mo , Yang Qing , Zhai Yi-Hui , Zhu Da-Qian , Chen Jing , Fang Xiao-Yan , Tang Xiao-Shan , Zhang Hui , Shen Qian , Xu Hong 
Published: July 2020

Background and objectives
During the coronavirus disease 2019 outbreak, the treatment of families with children on long-term KRT is challenging. This study was conducted to identify the current difficulties, worries regarding the next 2 months, and mental distress experienced by families with children on long-term KRT during the coronavirus disease 2019 outbreak and to deliver possible management approaches to ensure uninterrupted treatment for children on long-term KRT.

Design, setting, participants, & measurements
A multicenter online survey was conducted between February 10 and 15, 2020, among the families with children on long-term KRT from five major pediatric dialysis centers in mainland China. The primary caregivers of children currently on long-term KRT were eligible and included. Demographic information, severe acute respiratory syndrome coronavirus 2 infection status, current difficulties, and worries regarding the next 2 months were surveyed using a self-developed questionnaire. The Patient Health Questionnaire-9 and the General Anxiety Disorder Scale-7 were used to screen for depressive symptoms and anxiety, respectively.

Results
Among the children in the 220 families included in data analysis, 113 (51%) children were on dialysis, and the other 107 (49%) had kidney transplants. No families reported confirmed or suspected cases of coronavirus disease 2019. Overall, 135 (61%) and 173 (79%) caregivers reported having difficulties now and having worries regarding the next 2 months, respectively. Dialysis supply shortage (dialysis group) and hard to have blood tests (kidney transplantation group) were most commonly reported. A total of 29 (13%) caregivers had depressive symptoms, and 24 (11%) had anxiety. After the survey, we offered online and offline interventions to address their problems. At the time of the submission of this paper, no treatment interruption had been reported.

Conclusions
The coronavirus disease 2019 outbreak has had physical, mental, logistical, and financial effects on families with children on long-term KRT.
Investigating Accountants' Resistance to Move beyond Excel and Adopt New Data Analytics Technology
Authors: Schmidt Pamela J. , Riley Jennifer , Swanson Church Kimberly 
Published: July 2020

SYNOPSIS
A call to action has been sounded in accounting: Become a profession utilizing data analytics or become a profession bound for the history books. Accounting firms and corporations are investing in data analytics capabilities, but it is not clear whether accounting professionals are following their lead. Practitioner press indicates accountants resist the move beyond Excel even as organizations hire data scientists rather than accountants. This empirical study uses Status Quo Bias Theory to examine the resistance to data analytics technology by accounting and finance professionals. Surprisingly results indicate the perceived value does not mediate the effect of switching benefits and costs on resistance. Rather, switching benefits and perceived value are aligned as a single factor to reduce resistance while switching costs directly increase resistance. Researchers have focused substantial efforts toward data analytics in education and business. The troubling findings here suggest some accounting professionals resist adopting new analytics technology.
JEL Classifications: M41; M49.
Data Availability: Contact the authors.
Transverse dentoalveolar response of mandibular arch after rapid maxillary expansion (RME) with tooth-borne and bone-borne appliances:
Authors: Lo Giudice Antonino , Ronsivalle Vincenzo , Lagravere Manuel , Leonardi Rosalia , Martina Stefano , Isola Gaetano 
Published: July 2020

ABSTRACT

Objectives
To assess and compare spontaneous expansion of mandibular posterior teeth between tooth-borne (TB) and bone-borne (BB) rapid maxillary expansion (RME).

Materials and Methods
This study included 36 adolescents with bilateral maxillary crossbite receiving tooth-borne (average age: 14.4 ± 1.3 years) or bone-borne (average age: 14.7 ± 1.4 years) maxillary expansion. Cone beam computed tomography was acquired before expansion (T1) and after 6 months' retention (T2). Specific linear and angular measurements were performed in the coronal view to assess buccal inclinations and widths of mandibular posterior units. All data were statistically analyzed.

Results
In both groups there was a significant increase in buccal-lingual inclination of mandibular posterior teeth ranging from 1.67° to 2.30° in the TB group and from 1.46° to 2.11° in BB group. Mandibular posterior widths showed an increase ranging from 0.80 mm to 1.33 mm in TB group and from 0.64 mm to 0.96 mm in the BB group. No differences between groups were found for linear or angular measurements.

Conclusions
A clinically significant gain of space in the mandibular arch should not be expected after RME.
Superflex: Innovative Learning to Develop Social Attitude Competencies
Authors: Rachmah Huriah , Gunawan Rudy , Hendrawan Jajang Hendar 
Published: July 2020

The 2013 curriculum aims to produce students to have three competencies: attitude, knowledge and skills. Competence of attitude is divided into two, namely spiritual and social. Competence of social attitude is done during the learning process and assessment. But not on all subjects, the process and attitude assessment is done by the teacher. Assessment of attitudes in primary schools is done by classroom teachers, teachers of religious instruction lessons, PJOK, and extracurricular coaches. Social attitude is an integral part of social thinking because attitude is the fruit of thought. Learning Superflex® is a model developed in 2008 in the United States and in this research is adapted to help address issues related to social attitudes. This research uses descriptive analysis method. Some of the data is taken from the results of research that the author did and still runs until this year. The data is collaborated with the data obtained from the literature to produce this study. The conclusion of this study that innovative learning model depends on the creativity of teachers in generating motivation learners. The Superflex® learning model can be an inspiration for teachers as one of the innovative learning models that can build students' social attitudes.
PENGARUH MODEL PEMBELAJARAN GROUP INVESTIGATION BERNUANSA OUTDOOR STUDY TERHADAP PENGUASAAN KOMPETENSI PENGATAHUAN IPA KELAS IV
Authors: Krishna Dewi Gusti Ayu Putu Ary , Putra I Ketut Adnyana , Negara I Gusti Agung Oka 
Published: July 2020

Penelitian ini bertujuan untuk mengetahui pengaruh yang signifikan penguasaan kompetensi pengetahuan IPA antara kelompok siswa yang dibelajarkan dengan model pembelajaran group investigation bernuansa outdoor study dan kelompok siswa yang dibelajarkan dengan pembelajaran konvensional pada kelas IV SD Negeri Gugus Jendral Sudirman Denpasar Tahun Ajaran 2016/2017. Sampel penelitian adalah Kelas IV SD Negeri 6 Sesetan sebagai kelompok eksperimen dan Kelas IV SD Negeri 13 Sesetan sebagai kelompok kontrol. Data yang dikumpulkan dan dianalisis menggunakan uji t. Hasil penelitian yang diperoleh menunjukkan bahwa rata-rata penguasaan kompetensi pengetahuan IPA pada kelompok eksperimen yaitu 81,93 dan rata-rata kelompok kontrol yaitu 68,37. Setelah diuji dengan uji t, diperoleh t hitung yaitu 5,33 > t tabel 1,980 (taraf signifikansi 5%, dk 46+46-2 = 90), maka Ho ditolak dan Ha diterima. Dapat disimpulkan bahwa terdapat pengaruh yang signifikan penguasaan model pembelajaran group investigation bernuansa outdoor study terhadap penguasaan kompetensi pengetahuan IPA antara kelompok siswa yang dibelajarkan dengan model pembelajaran group investigation bernuansa outdoor study dan kelompok siswa yang dibelajarkan dengan pembelajaran konvensional
THE IMPACT OF SCHOOL LITERACY MOVEMENT (GSL) ON THE LITERACY ABILITY OF THE FIFTH GRADERS AT SD NEGERI GUNUNG SARI, RAPPOCINI DISTRICT, MAKASSAR CITY
Authors: Syawaluddin Ahmad , Haedah Nur 
Published: July 2020

This research was aimed at knowing the impact of (GLS) on the students’ literacy ability of the fifth graders at SD Negeri Gunung Sari I, Rappocini district, Makassar city in the school year 2016/2017. The research approach used a quantitative approach with Pre-experimental Research design. The sample was selected with purposive sampling by choosing class V as experiment class with the total number of 66 students and those who were present were 50 students. The techniques of data collection used in this research were test and documentation. The data collected from the literacy ability test result were then analyzed using descriptive statistical analysis and inferential statistical analysis using sample t-test of Wilcoxon Test by using the test of two sides (two tailed test). To test the normality of the data distribution, Kolmogrov-Smirnov Normality Test was used with Asymp Sig. (2-Tailed) of 0.002 for pretest data and 0.003 for posttest data. Literacy ability on initial test (pretest) was in very satisfactory category with the mean of 83.99 and the literacy ability in the final test (posttest) was in very satisfactory category with the mean of 90.23. Hypothesis testing was done by using Wilcoxon Test Asymp Sig. (2-tailed) the value was 0.00 < 0.05. The conclusion of research based on the result of analysis showed that there is an impact of school literacy movement (GLS) on students’ literacy ability of fifth graders of SD Negeri Gunung Sari I in Rappocini disctrict, Makassar city
AN APPLICATION OF MIND MAPPING TEACHING MODEL TO ENHANCE NATURAL SCIENCE LEARNING ACHIEVEMENT IN THE FIFTH GRADERS IN THE FIRST SEMESTER AT SD N 4 KALIUNTU
Authors: Wibowo Nur 
Published: July 2020

This study was aimed at enhancing natural science learning achievement in the fifth graders in the first semester at SD N4 Kaliuntu in the school year 2017/2018. The data for the students’ natural science learning achievement were collected with a test and assessment rubric. The data were analyzed using descriptive statistical analysis, quantitative descriptive method, and gain score (Gn). The result of data analysis showed an increase proven by the pretest score for the students’ science learning achievement of 65.7% , categorized as a low score. The science learning achievement score increased in the first cycle to 71.63%, categorized as average which increased again in the second cycle to 82.34%, showing science learning achievement in the high category. So, there was an increase in learning achievement of 5.93 from pre-cycle to the first cycle, an increase in learning achievement of 10.71 from the first cycle to the second cycle. Thus, it can be concluded that there was an increase in the students’ natural science learning achievement in this study through the implementation of Mind Mapping teaching model.
Pengaruh Model Pembelajaran Kooperatif Tipe Course Review Horay Berbantuan Media Gambar Terhadap Hasil Belajar IPA
Authors: Sri Antari Ni Luh Gita , Pudjawan Kt. , Wibawa I Md. Citra 
Published: July 2020

Penelitian ini bertujuan untuk mengetahui perbedaan hasil belajar IPA yang signifikan antara kelompok siswa yang dibelajarkan dengan model pembelajaran kooperatif tipe Course Review Horay berbantuan media gambar dan kelompok siswa yang dibelajarkan dengan model pembelajaran konvensional pada siswa kelas III SD Gugus IV Kecamatan Buleleng Tahun Pelajaran 2017/2018. Jenis penelitian ini adalah eksperimen semu (quasi eksperimental) dan rancangan penelitian yang digunakan adalah post-test only control group design. Populasi dalam penelitian ini adalah seluruh siswa kelas III SD Gugus IV Kecamatan Buleleng Tahun Pelajaran 2017/2018 yang berjumlah 123 orang. Sampel penelitian ini diambil dengan teknik Random Sampling yaitu: siswa kelas III SD N 3 Penglatan yang bejumlah 20 orang dan siswa kelas III SD N 3 Alasangker yang berjumlah 24 orang. Metode pengumpulan data hasil belajar IPA menggunakan metode tes berupa instrumen pilihan ganda objektif. Data hasil belajar IPA dianalisis meggunakan analisis statistik deskriptif dan statistik inferensial (uji-t). Hasil penelitian menunjukkan bahwa terdapat perbedaan hasil belajar IPA yang signifikan antara kelompok siswa yang dibelajarkan dengan model pembelajaran kooperatif tipe Course Review Horay berbantuan media gambar dan kelompok siswa yang dibelajarkan dengan model pembelajaran konvensional. Dengan demikian dapat disimpulkan bahwa model pembelajaran kooperatif tipe Course Review Horay berbantuan media gambar berpengaruh positif terhadap hasil belajar IPA siswa kelas III SD N 3 Penglatan Tahun Pelajaran 2017/2018.