bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polydioxanone implants: A systematic review on safety and performance in patients
Authors: Martins Joana A , Lach Antonina A , Morris Hayley L , Carr Andrew J , Mouthuy Pierre-Alexis 
Published: November 2019

Background Medical devices made of polydioxanone (a synthetic biodegradable polymer) have been available since the early 1980s. However, no review regarding their performance and safety has been published. Objective This systematic review intends to review and assess commercially available polydioxanone implants and their safety and performance in patients. Methods We searched for approved polydioxanone implants in several Food and Drug Administration databases. Then, we performed a literature search for publications and clinical trials where polydioxanone devices were implanted in patients. This search was performed on MEDLINE, Embase, Scopus and other databases. Safety and performance of polydioxanone implants in patients were assessed and compared with the implantation of non-polydioxanone devices, when possible, based on scoring systems developed by the authors that analyse surgical site infection rates, inflammatory reaction rates, foreign body response, postoperative pain and fever. Results Food and Drug Administration databases search revealed that 48 implants have been approved since 1981, with 1294 adverse reactions or product malfunction in the last decade and 16 recalls. A total of 49 clinical trials and 104 scientific publications were found. Polydioxanone sutures and meshes/plates had low rates of surgical site infection, inflammatory reaction, foreign body response and postoperative fever. Polydioxanone clips/staples reported high rates of surgical site infection, postoperative fever and pain, with sub-optimal clinical performance and poor safety rates. The remaining implants identified showed high levels of safety and performance. Safety scores of polydioxanone implants and non-polydioxanone alternatives are similar. Polydioxanone monofilament sutures perform better than non-polydioxanone alternatives but performance did not differ with remaining polydioxanone implant types. Conclusions Although polydioxanone clips/staples should be implanted with caution and monitored carefully, in general, safety and performance scores of other polydioxanone implants did not differ from non-polydioxanone alternatives. This review will be a useful reference for researchers and industries developing new polydioxanone medical devices.
The impact of therapeutic hypothermia in elderly out-of-hospital cardiac arrest: A multicenter retrospective observational propensity-matched study
Authors: Park Jeong Ho , Choi Seung Pill , Park Kyu Nam , Son Yoo Dong , Lim Hoon , Lee Dong Hoon 
Published: November 2019

Background: The therapeutic hypothermia protocol for out of hospital cardiac arrest is not standardized and the decision to apply therapeutic hypothermia relies on a physician’s judgment. Elderly patients who rely on this judgment are less likely to receive therapeutic hypothermia. Objectives: This study aimed to provide an analysis of the impact and utility of therapeutic hypothermia on elderly out of hospital cardiac arrest. Methods: This was a multicenter, retrospective, observational, registry-based study from 2007 to 2012. Adults who suffered out-of-hospital cardiac arrest and were treated with therapeutic hypothermia were included. We divided the patients into a group of elderly patients 65 years or older and a group of young adults under 65 years old and compared the neurologic outcomes and adverse events after one-to-one matching by propensity score. Results: In total, 930 patients were enrolled in the study. Among these patients, 343 were ⩾65 years, while 587 were <65 years. Of the adverse events in therapeutic hypothermia, hyperglycemia (51.31%), hypotension (41.98%) during cooling was more frequent in aged ⩾65 years and rebound hyperthermia (7.14%) and hypotension (29.93%) during rewarming. After propensity score matching was applied to all subjects of the study, 247 matched pairs of patients were available. The two groups showed no statistically significant difference in the adverse events during therapeutic hypothermia. Conclusion: Elderly patients exhibited a decreased survival to hospital discharge and good neurologic outcomes. The two groups showed no differences in the frequency of adverse events during therapeutic hypothermia, when comparing in a propensity score matching cohort analysis.
Assessment of lumbar disc herniaton using fractional anisotropy in diffusion tensor imaging along with conventional T2-weighted imaging
Authors: Perri Marco , D’Elia Marialuisa , Castorani Giulia , Balzano Rosario Francesco , Pennelli Annamaria , Al-Badayneh Bilal , Russo Annunziata , Guglielmi Giuseppe , Popolizio Teresa 
Published: November 2019

Objective To assess the usefulness of diffusion tensor imaging and its fractional anisotropy map along with conventional T2-weighted imaging in evaluating the anisotropic water diffusion variations of annulus fibres involved in herniation disc pathology. Materials and methods Seventy-five patients with previous medical ethics committee approval and informed consent experiencing low back pain were selected for this prospective randomised blinded trial. Lumbar disc fractional anisotropy maps were obtained acquiring diffusion tensor sequences on a 3T machine. The matrix of nucleus pulposus and structures of annulus fibres were analysed using fractional anisotropy textural features to highlight any presence of lumbar disc herniation. Observer variability and reliability between two neuroradiologists were evaluated. The χ2 test, two-tailed t test and linear regression analysis were used to focus differences in patients’ demographic data and magnetic resonance imaging findings. Results Annular fissures with extrusions were identified using diffusion tensor imaging in 10 out of 17 discs (study group) previously assessed as bulging discs using conventional magnetic resonance imaging. Eighteen extrusions out of 39 (study group) disc levels were identified on diffusion tensor imaging compared to eight extrusions highlighted on T2-weighted imaging ( P < 0.01). All eight (study group) disc extrusions evaluated on T2-weighted imaging showed annular fissures on diffusion tensor imaging. Seven out of 14 (study group) protrusions highlighted on T2-weighted imaging had no annular fissures on diffusion tensor imaging; thirty-six disc levels in the control group had no evidence of annular fissures on diffusion tensor imaging ( P > 0.01). Conclusions The addition of diffusion tensor imaging sequences and fractional anisotropy mapping to a conventional magnetic resonance imaging protocol could be useful in detecting annular fissures and lumbar disc herniation.
Radiation-induced sarcoma in a cat following hypofractionated, palliative intent radiation therapy for large-cell lymphoma
Authors: Cook Matthew R , Martinez Michael P , Fenger Joelle M , Desai Noopur C 
Published: November 2019

Case summary A 5-year-old female spayed domestic shorthair cat was presented with a 4.5 × 3 cm ulcerated cutaneous mass on the nasal bridge with extension into the nasal cavity. Tissue biopsy was obtained and a diagnosis of large-cell lymphoma was confirmed on histopathology. The cat was started on prednisolone and injectable chemotherapy; however, only a partial response was observed. A CT scan revealed a highly infiltrative mass with extensive subcutaneous involvement, extending into the nasal cavity, resulting in lysis of numerous nasal and facial bones. The cat received hypofractionated, palliative intent radiation therapy (four fractions of 8 Gray) and a complete clinical response was achieved. Nine months after radiation therapy, minimal residual intranasal disease was observed on advanced imaging. Sixty-nine months after the completion of radiotherapy, a mass was observed dorsal to the right eye within the previous radiation field. CT scan revealed a mass associated with the right frontal sinus with extension throughout the nasal cavity and facial bones. Histopathology was consistent with a moderately differentiated sarcoma. Seventy-one months post-radiation therapy, the cat developed neurologic clinical signs and was humanely euthanized. Radiation-induced sarcoma was suspected based on human criteria, which included history of irradiation and tumor development within the irradiated field, a latent period after irradiation prior to the development of the second tumor and histopathologic confirmation of a different malignant neoplasm at the irradiated site. Relevance and novel information To our knowledge, this is the first report of a malignant radiation-induced sarcoma in a cat. Based on this case, radiation-induced sarcomas should be considered as a late-term side effect associated with radiation therapy in cats.
Outcome of Delayed Treatment of Supracondylar Elbow Fractures in Children in Hasan Sadikin Hospital Bandung and Santosa Hospital Bandung
Authors: Mahyudin  , Ismiarto Yoyos Dias 
Published: November 2019

Objectives: Supracondylar fractures of the elbow are common in children and percutaneous pinning usually advocated as a treatment for this kind of fracture. However, the treatment is often delayed in areas where healthcare resources are limited. The objective of this retrospective study was to assess functional outcomes after delayed treatment of supracondylar elbow fractures in children. Methods: We retrospectively reviewed the medical charts of 38 children aged 2 to 15 years in whom surgery for extension-type supracondylar elbow fractures was delayed by more than 1 week. The 22 boys and 16 girls with a mean age of 5 years 3 months had severe fracture displacement (12 stages III and 26 stage IV according to Lagrange and Rigault classification scheme). The mean time to treatment was 7 days (range: 1-4 weeks). Open reduction and crossed K-wire fixation via the posterior approach were performed in all patients. Functional outcomes were evaluated using Flynn’s criteria. Results: Outcomes were satisfactory in 31 (81,5%) of patients. At last follow-up after a mean of 3 months, three (7,8%) patients had limited in elbow motion. No case of compartment syndrome, surgical site infection and re-operation. Conclusion: Despite an average time to surgery of 16 days, the outcome was satisfactory in (81,5%) of cases. Delayed treatment was not associated with an increased rate of postoperative complications.
PCL Reconstruction Using Adjustable Buttons with Outside-In Tunnel for Tibial Fixation: A case report
Authors: Suvarly Prettysia , Sindunata Nyoman Aditya , Siahaan Lasa Dhakka , Mandagi Tommy , Butarbutar John 
Published: November 2019

Introduction: Posterior cruciate ligament (PCL) reconstruction needs a large and long graft. An allograft is a preferable option for thicker graft but its availability is limited in Indonesia. Alternatively, autograft needs to be folded several times for sufficient thickness but it will be shorter and only applicable for the inside-out method. We present a case of PCL reconstruction using a double adjustable button fixation with the outside-in tibia tunneling method. Case Presentation: A fifty-five-year-old male came to our office with an unstable right knee after he fell 1 month ago. Physical examination showed positive posterior drawer and mild right knee effusion, other findings were normal. MRI revealed a total PCL rupture. Two weeks later, the PCL reconstruction was done using autograft from gracillis and semitendinous. A large adjustable button was placed on the tibia tunnel, using the outside-in technique. Knee was stable postoperatively. Discussion: PCL reconstruction using double adjustable buttons was chosen to accommodate larger but shorter autografts. The outside-in tibial tunnel has less risk of graft laxity less expensive and more simple technically compared to inside-out adjustable button tunnel. Conclusion: Tibial fixation using an adjustable large button should be considered in PCL reconstruction with short autograft.
MicroRNA-146a protects against myocardial ischaemia reperfusion injury by targeting Med1
Authors: Zhang Tiantian , Ma Yiwen , Gao Lin , Mao Chengyu , Zeng Huasu , Wang Xiaofei , Sun Yapin , Gu Jianmin , Wang Yue , Chen Kan , Han Zhihua , Fan Yuqi , Gu Jun , Zhang Junfeng , Wang Changqian 
Published: November 2019

Abstract
Background
Myocardial ischaemia reperfusion injury (MIRI) is a difficult problem in clinical practice, and it may involve various microRNAs. This study investigated the role that endogenous microRNA-146a plays in myocardial ischaemia reperfusion and explored the possible target genes.

Methods
MIRI models were established in microRNA-146a deficient (KO) and wild type (WT) mice. MicroRNA-146a expression was evaluated in the myocardium of WT mice after reperfusion. The heart function, area of myocardium infarction and in situ apoptosis were compared between the KO and WT mice. Microarray was used to explore possible target genes of microRNA-146a, while qRT-PCR and dual luciferase reporter assays were used for verification. Western blotting was performed to detect the expression levels of the target gene and related signalling molecules. A rescue study was used for further testing.

Results
MicroRNA-146a was upregulated 1 h after reperfusion. MicroRNA-146a deficiency decreased heart function and increased myocardial infarction and apoptosis. Microarray detected 19 apoptosis genes upregulated in the KO mice compared with the WT mice. qRT-PCR and dual luciferase verified that Med1 was one target gene of microRNA-146a. TRAP220, encoded by Med1 in the KO mice, was upregulated, accompanied by an amplified ratio of Bax/Bcl2 and increased cleaved caspase-3. Inhibition of microRNA-146a in H9C2 cells caused increased TRAP220 expression and more apoptosis under the stimulus of hypoxia and re-oxygenation, while knockdown of the increased TRAP220 expression led to decreased cell apoptosis.

Conclusions
MicroRNA-146a exerts a protective effect against MIRI, which might be partially mediated by the target gene Med1 and related to the apoptosis signalling pathway.
Performance Enhancement of Modified 3D SWCNT/RVC Electrodes Using Microwave-Irradiated Graphene Oxide
Authors: Aldalbahi Ali , Rahaman Mostafizur , Almoiqli Mohammed 
Published: November 2019

Abstract
The goal of this article is to increase the electrode performance of 3D CNT/RVC electrodes by improving the ease of ion adsorption to and ion desorption from the electrode surfaces. This achievement was done by preparing different composites of synthesized microwave-irradiated graphene oxide (mwGO) with CNT and coated on RVC. The morphology of GO was examined by field emission scanning electron microscopy (FESEM) and X-ray diffraction (XRD) study. Its surface property was checked by energy-dispersive X-ray spectra (EDX), and Fourier transform infrared spectra; whereas, for mwGO by XRD, Raman spectra, and X-ray photoelectron spectra (XPS), which revealed some structural changes of GO after irradiation, where CNTs, being sandwiched between graphene layers, built 3D highly porous architecture inside the electrodes. The electrochemical test of composite electrodes showed increased electrodes conductivity and afforded rapid ions diffusion. It is observed that the 9-CNT/mwGO/RVC composite electrode performed as the best electrode, which showed 29% increment in specific capacitance value compared to the normal CNT/RVC electrode. This best electrode also showed very high cyclic stability in its cyclic voltammetry test that maintained 97% current stability after 2000 cycles, indicating that the electrode can be an effective material for water purification technology.

Graphical Abstract
The role of PPARγ in childhood obesity-induced fractures
Authors: McCann Matthew R. , Ratneswaran Anusha 
Published: November 2019

AbstractGlobally, obesity is on the rise with ~ 30% of the world’s population now obese, and childhood obesity is following similar trends. Childhood obesity has been associated with numerous chronic conditions, including musculoskeletal disorders. This review highlights the effects of childhood adiposity on bone density by way of analyzing clinical studies and further describing two severe skeletal conditions, slipped capital femoral epiphysis and Blount’s disease. The latter half of this review discusses bone remodeling and cell types that mediate bone growth and strength, including key growth factors and transcription factors that help orchestrate this complex pathology. In particular, the transcriptional factor peroxisome proliferator-activated receptor gamma (PPARγ) is examined as it is a master regulator of adipocyte differentiation in mesenchymal stem cells (MSCs) that can also influence osteoblast populations. Obese individuals are known to have higher levels of PPARγ expression which contributes to their increased adipocyte numbers and decreased bone density. Modulating PPAR*gamma* signaling can have significant effects on adipogenesis, thereby directing MSCs down the osteoblastogenesis pathway and in turn increasing bone mineral density. Lastly, we explore the potential of PPARγ as a druggable target to decrease adiposity, increase bone density, and be a treatment for children with obesity-induced bone fractures.
A note on genetic parameters and accuracy of estimated breeding values in honey bees
Authors: Brascamp Evert W. , Bijma Piter 
Published: November 2019

Abstract
Background
In honey bees, observations are usually made on colonies. The phenotype of a colony is affected by the average breeding value for the worker effect of the thousands of workers in the colony (the worker group) and by the breeding value for the queen effect of the queen of the colony. Because the worker group consists of multiple individuals, interpretation of the variance components and heritabilities of phenotypes observed on the colony and of the accuracy of selection is not straightforward. The additive genetic variance among worker groups depends on the additive genetic relationship between the drone-producing queens (DPQ) that produce the drones that mate with the queen.

Results
Here, we clarify how the relatedness between DPQ affects phenotypic variance, heritability and accuracy of the estimated breeding values of replacement queens. Second, we use simulation to investigate the effect of assumptions about the relatedness between DPQ in the base population on estimates of genetic parameters. Relatedness between DPQ in the base generation may differ considerably between populations because of their history.

Conclusions
Our results show that estimates of (co)variance components and derived genetic parameters were seriously biased (25% too high or too low) when assumptions on the relationship between DPQ in the statistical analysis did not agree with reality.
An isoform of the plastid RNA polymerase-associated protein FSD3 negatively regulates chloroplast development
Authors: Lee Sangyool , Joung Young Hee , Kim Ju-Kon , Do Choi Yang , Jang Geupil 
Published: November 2019

Abstract
Background
Plastid-encoded RNA polymerase (PEP) plays an essential role in chloroplast development by governing the expression of genes involved in photosynthesis. At least 12 PEP-associated proteins (PAPs), including FSD3/PAP4, regulate PEP activity and chloroplast development by modulating formation of the PEP complex.

Results
In this study, we identified FSD3S, a splicing variant of FSD3; the FSD3 and FSD3S transcripts encode proteins with identical N-termini, but different C-termini. Characterization of FSD3 and FSD3S proteins showed that the C-terminal region of FSD3S contains a transmembrane domain, which promotes FSD3S localization to the chloroplast membrane but not to nucleoids, in contrast to FSD3, which localizes to the chloroplast nucleoid. We also found that overexpression of FSD3S negatively affects photosynthetic activity and chloroplast development by reducing expression of genes involved in photosynthesis. In addition, FSD3S failed to complement the chloroplast developmental defects in the fsd3 mutant.

Conclusion
These results suggest FSD3 and FSD3S, with their distinct localization patterns, have different functions in chloroplast development, and FSD3S negatively regulates expression of PEP-dependent chloroplast genes, and development of chloroplasts.
The association of MTHFR C677T variant with increased risk of ischemic stroke in the elderly population: a meta-analysis of observational studies
Authors: Chang Guilin , Kuai Zheng , Wang Jia , Wu Jiayu , Xu Kan , Yuan Ying , Hu Yu 
Published: November 2019

AbstractBackgroundC677T point mutation in methylenetetrahydrofolate reductase (MTHFR) gene have been found to be associated with ischemic stroke in general population, while the results seem inconsistent. We aim to assess the association between variant MTHFR C677T variant and increased risk of ischemic stroke and focus on the elderly population.MethodsWe searched PubMed, Embase, Cochrane Library, and Web of Science for eligible studies. Odds ratios (ORs) were calculated with the two-tailed 95% confidence intervals (CIs) by using a random effects model to evaluate any possible association. Among the Chinese and non-Chinese populations, we conducted a subgroup analysis.ResultsThe electronic database search yielded 1,358 citations as of December 2017; finally, nine case-control studies involving 3,337 subjects fulfilled our eligibility criteria for inclusion in the study. The pooled results showed that MTHFR C677T variant increased the risk of ischemic stroke (OR = 1.23, 95%CI 1.06–1.43,P = 0.0067 for CT + TT vs. CC; OR = 1.18, 95%CI 1.01–1.38,P = 0.0333 for CT vs. CC; OR = 1.41, 95%CI 1.14–1.75,P = 0.0016 for TT vs. CC; OR = 1.27, 95%CI 1.05–1.54,P = 0.0145 for TT vs. CC + CT; OR = 1.18, 95%CI 1.06–1.31,P = 0.0023 for T-allele vs. C-allele). Further subgroup analyses in the Chinese population indicated that MTHFR C677T variant was associated with a higher risk of ischemic stroke.ConclusionOur findings showed that T-allele increases risk for stroke in the pooled sample. This association was statistically significant in the Chinese cohorts and showed a similar trend in the non-Chinese cohorts. (Word count: 237).
Indicators for mode of delivery in pregnant women with uteruses scarred by prior caesarean section: a retrospective study of 679 pregnant women
Authors: Hua Zhifen , El Oualja Fadwa 
Published: November 2019

Abstract
Background
The delivery mode for pregnant women with uteruses scarred by prior caesarean section (CS) is a controversial issue, even though the CS rate has risen in the past 20 years. We performed this retrospective study to identify the factors associated with preference for CS or vaginal birth after CS (VBAC).

Methods
Pregnant women (n = 679) with scarred uteruses from Moulay Ali Cherif Provincial Hospital, Rashidiya, Morocco, were enrolled. Gestational age, comorbidity, fetal position, gravidity and parity, abnormal amniotic fluid, macrosomia, placenta previa or abruptio, abnormal fetal presentation, premature rupture of fetal membrane with labor failure, poor progression in delivery, and fetal outcomes were recorded.

Results
Out of 679 pregnant women ≥28 gestational weeks, 351 (51.69%) had a preference for CS. Pregnant women showed preference for CS if they were older (95% CI 1.010–1.097), had higher gestational age (95% CI 1.024–1.286), and a shorter period had passed since the last CS (95% CI 0.842–0.992). Prior gravidity (95% CI 0.638–1.166), parity (95% CI 0.453–1.235), vaginal delivery history (95% CI 0.717–1.818), and birth weight (95% CI 1.000–1.001) did not influence CS preference. In comparison with fetal preference, maternal preference was the prior indicator for CS. Correlation analysis showed that pregnant women with longer intervals since the last CS and history of gravidity, parity, and vaginal delivery showed good progress in the first and second stages of vaginal delivery.

Conclusions
We concluded that maternal and gestational age and interval since the last CS promoted CS preference among pregnant women with scarred uteruses.