bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does auxiliary cerclage wiring provide intrinsic stability in cephalomedullary nailing of trochanteric and subtrochanteric fractures?
Authors: Rehme Julia , Woltmann Alexander , Brand Andreas , von Rüden Christian 
Published: September 2020

AbstractPurposeThe aim of this study was to assess functional and radiological results following cephalomedullary nailing with and without use of auxiliary cable cerclages in a large series of trochanteric and subtrochanteric femoral fractures.MethodsIn a retrospective study of prospectively collected data between January 2014 and March 2019, a total of 260 consecutive patients (155 women and 105 men) with the diagnosis of AO/OTA A1 to A3 fractures were included. The mean age of patients was 76.4 ± 15.6 years. According to the AO/OTA classification, 72 A1 fractures, 124 A2 fractures, and 64 A3 fractures were found. In 72 patients with auxiliary cerclage wiring three A1 fractures, 27 A2 fractures and 42 A3 fractures were assessed. In the patient group with auxiliary cerclages, fracture healing according to the Radiographic Union Score for Hip (RUSH) within one year after surgery was assessed in 68 out of 72 patients (healing rate 94%). The mean RUSH in the group with cerclages was 28.7 ± 2.2 points and was 28.5 ± 2.2 points in the group without cerclages (p = 0.72). In 91 patients available for a complete follow-up, mean functional outcome according to the Lower Extremity Functional Scale (LEFS) was 65.3 ± 17.2 points in the group with cerclages versus 58.4 ± 21 points in the group without cerclages (p = 0.04).ConclusionThe additional use of cerclages provides intrinsic stability and enables axial alignment and medial cortical support during anatomical fracture reduction and cephalomedullary nail insertion. In the current study, this technique resulted in significantly better functional long-term outcomes than without cerclages. Therefore, it can be recommended as a useful supportive tool especially in comminuted trochanteric and subtrochanteric fractures. Trial registration number DRKS00020550, 01/30/2020, retrospectively registered.
Analysis of Financial Risk Protection Indicators in Myanmar for Paediatric Surgery
Authors: Nataraja Ramesh Mark , Yin Mar Oo  , Andolfatto Lilly , Moore Eileen M , Watters David , Aye Aye  , Htun Oo  , Moe Moe Tin  , Shrime Mark , McLeod Elizabeth 
Published: September 2020

AbstractPurposeTo estimate proportion of Myanmar paediatric population at risk of impoverishment and catastrophic expenditure due to emergency surgical intervention.MethodsProspective data were collected at two tertiary surgical centres including income, household expenses, expenses related to surgery. Data analysis was performed to estimate out‐of‐pocket (OOP) direct medical costs and OOP total costs. Catastrophic expenditure: expense exceeded 10% of household income. Risk of impoverishment: net income drops were below an impoverishment threshold (PPP—purchasing power parity): I$ 2.00 PPP/day, I$ 1.25/day PPP, national poverty line. Distribution of income was estimated using a gamma distribution. Comparison to an adult cohort was performed using Chi‐square test with a p value of <0.05 being significant.ResultsA total of 145 surveys were collected, and 119 (82.1%) contained sufficient data: Paediatric Centre (n = 99) and Adult Centre (n = 20). Overall average per patient direct medical and non‐medical OOP costs was I$493: Centre 1: I$540 PPP (range I$41‐6,588 PPP) and Centre 2: I$437 PPP (range I$ 36‐1,405 PPP). 64% experienced catastrophic expense. There is no significant difference between the centres in the risks of impoverishment or catastrophic expenditure (p = 0.05). Up to 44% are at risk of catastrophic expenditure should surgery be required. Most of the risk (90%) is derived from direct non‐medical costs. A high proportion were at the national poverty line threshold (36.1%). Seeking surgical treatment would imperil up to 37% at the national poverty line threshold, and up to 5.7% at the I$2 PPP per day limit.ConclusionsA large proportion of the Myanmar population are at risk of impoverishment or catastrophic expenditure should they require surgery. Financial risk protection mechanisms are needed.
Evaluation of snow cover and snow water equivalent in the continental Arctic in CMIP5 models
Authors: Santolaria-Otín María , Zolina Olga 
Published: September 2020

AbstractSpatial and temporal patterns of snow cover extent (SCE) and snow water equivalent (SWE) over the terrestrial Arctic are analyzed based on multiple observational datasets and an ensemble of CMIP5 models during 1979–2005. For evaluation of historical simulations of the Coupled Model Intercomparison Project (CMIP5) ensemble, we used two reanalysis products, one satellite-observed product and an ensemble of different datasets. The CMIP5 models tend to significantly underestimate the observed SCE in spring but are in better agreement with observations in autumn; overall, the observed annual SCE cycle is well captured by the CMIP5 ensemble. In contrast, for SWE, the annual cycle is significantly biased, especially over North America, where some models retain snow even in summer, in disagreement with observations. The snow margin position (SMP) in the CMIP5 historical simulations is in better agreement with observations in spring than in autumn, when close agreement across the CMIP5 models is only found in central Siberia. Historical experiments from most CMIP5 models show negative pan-Arctic trends in SCE and SWE. These trends are, however, considerably weaker (and less statistically significant) than those reported from observations. Most CMIP5 models can more accurately capture the trend pattern of SCE than that of SWE, which shows quantitative and qualitative differences with the observed trends over Eurasia. Our results demonstrate the importance of using multiple data sources for the evaluation of snow characteristics in climate models. Further developments should focus on the improvement of both dataset quality and snow representation in climate models, especially ESM-SnowMIP.
Large-scale control on the frequency of tropical cyclones and seeds: a consistent relationship across a hierarchy of global atmospheric models
Authors: Hsieh Tsung-Lin , Vecchi Gabriel A. , Yang Wenchang , Held Isaac M. , Garner Stephen T. 
Published: September 2020

AbstractA diagnostic framework is developed to explain the response of tropical cyclones (TCs) to climate in high-resolution global atmospheric models having different complexity of boundary conditions. The framework uses vortex dynamics to identify the large-scale control on the evolution of TC precursors—first non-rotating convective clusters and then weakly rotating seeds. In experiments with perturbed sea surface temperature (SST) and $$\hbox {CO}_2$$

CO
2

concentration from the historical values, the response of TCs follows the response of seeds. The distribution of seeds is explained by the distribution of the non-rotating convective clusters multiplied by a probability that they transition to seeds. The distribution of convective clusters is constrained by the large-scale vertical velocity and is verified in aquaplanet experiments with shifting Inter tropical Convergence Zones. The probability of transition to seeds is constrained by the large-scale vorticity via an analytical function, representing the relative importance between vortex stretching and vorticity advection, and is verified in aquaplanet experiments with uniform SST. The consistency between seed and TC responses breaks down substantially when the realistic SST is perturbed such that the spatial gradient is significantly enhanced or reduced. In such cases, the difference between the responses is explained by a change in the ventilation index, which influences the fraction of seeds that develop into TCs. The proposed TC-climate relationship serves as a framework to explain the diversity of TC projection across models and forcing scenarios.
Altered DNA methylation profiles in blood from patients with sporadic Creutzfeldt–Jakob disease
Authors: Dabin Luke C. , Guntoro Fernando , Campbell Tracy , Bélicard Tony , Smith Adam R. , Smith Rebecca G. , Raybould Rachel , Schott Jonathan M. , Lunnon Katie , Sarkies Peter , Collinge John , Mead Simon , Viré Emmanuelle 
Published: September 2020

AbstractPrion diseases are fatal and transmissible neurodegenerative disorders caused by the misfolding and aggregation of prion protein. Although recent studies have implicated epigenetic variation in common neurodegenerative disorders, no study has yet explored their role in human prion diseases. Here we profiled genome-wide blood DNA methylation in the most common human prion disease, sporadic Creutzfeldt–Jakob disease (sCJD). Our case–control study (n = 219), when accounting for differences in cell type composition between individuals, identified 38 probes at genome-wide significance (p < 1.24 × 10–7). Nine of these sites were taken forward in a replication study, performed in an independent case–control (n = 186) cohort using pyrosequencing. Sites in or close to FKBP5, AIM2 (2 probes), UHRF1, KCNAB2 successfully replicated. The blood-based DNA methylation signal was tissue- and disease-specific, in that the replicated probe signals were unchanged in case–control studies using sCJD frontal-cortex (n = 84), blood samples from patients with Alzheimer’s disease, and from inherited and acquired prion diseases. Machine learning algorithms using blood DNA methylation array profiles accurately distinguished sCJD patients and controls. Finally, we identified sites whose methylation levels associated with prolonged survival in sCJD patients. Altogether, this study has identified a peripheral DNA methylation signature of sCJD with a variety of potential biomarker applications.
Enhanced numerical integration scheme based on image compression techniques: Application to rational polygonal interpolants
Authors: Petö Márton , Duvigneau Fabian , Juhre Daniel , Eisenträger Sascha 
Published: September 2020

AbstractPolygonal finite elements offer an increased freedom in terms of mesh generation at the price of more complex, often rational, shape functions. Thus, the numerical integration of rational interpolants over polygonal domains is one of the challenges that needs to be solved. If, additionally, strong discontinuities are present in the integrand, e.g., when employing fictitious domain methods, special integration procedures must be developed. Therefore, we propose to extend the conventional quadtree-decomposition-based integration approach by image compression techniques. In this context, our focus is on unfitted polygonal elements using Wachspress shape functions. In order to assess the performance of the novel integration scheme, we investigate the integration error and the compression rate being related to the reduction in integration points. To this end, the area and the stiffness matrix of a single element are computed using different formulations of the shape functions, i.e., global and local, and partitioning schemes. Finally, the performance of the proposed integration scheme is evaluated by investigating two problems of linear elasticity.
Primary glomus tumour of the pituitary gland: diagnostic challenges of a rare and potentially aggressive neoplasm
Authors: Quah Boon Leong , Donofrio Carmine Antonio , La Rosa Stefano , Brouland Jean-Philippe , Cossu Giulia , Djoukhadar Ibrahim , Mayers Helen , Shenjere Patrick , Pereira Marta , Pathmanaban Omar N. , Murtaza Muhammed O. , Gattamaneni Rao , Roncaroli Federico , Karabatsou Konstantina 
Published: September 2020

AbstractPrimary non-neuroendocrine tumours of the pituitary gland and sella are rare lesions often challenging to diagnose. We describe two cases of clinically aggressive primary glomus tumour of the pituitary gland. The lesions occurred in a 63-year-old male and a 30-year-old female who presented with headache, blurred vision and hypopituitarism. Neuroimaging demonstrated large sellar and suprasellar tumours invading the surrounding structures. Histologically, the lesions were characterised by angiocentric sheets and nests of atypical cells that expressed vimentin, smooth muscle actin and CD34. Perivascular deposition of collagen IV was also a feature. Case 2 expressed synaptophysin. INI-1 (SMARCB1) expression was preserved. Both lesions were mitotically active and demonstrated a Ki-67 labelling index of 30%. Next-generation sequencing performed in case 1 showed no mutations in the reading frame of 37 commonly mutated oncogenes, including BRAF and KRAS. Four pituitary glomus tumours have previously been reported, none of which showed features of malignant glomus tumour. Similar to our two patients, three previous examples displayed aggressive behaviour.
Minimizing shrinkage of acute brain slices using metal spacers during histological embedding
Authors: Bolduan Felix , Grosser Sabine , Vida Imre 
Published: September 2020

AbstractThe morphological structure of neurons provides the basis for their functions and is a major focus of contemporary neuroscience studies. Intracellular staining of single cells in acute slices is a well-established approach, offering high-resolution information on neuronal morphology, complementing their physiology. Despite major technical advances, however, a common histological artifact often precludes precise morphological analysis: shrinkage of the sampled tissue after embedding for microscopy. Here, we describe a new approach using a metal spacer, sandwiched between two coverslips to reduce shrinkage of whole-mount slice preparations during embedding with aqueous mounting medium under a coverslip. This approach additionally allows imaging the slices from both sides to obtain better quality images of deeper structures. We demonstrate that the use of this spacer system can efficiently and stably reduce the shrinkage of slices, whereas conventional embedding methods without spacer or with agar spacer cause severe, progressive shrinkage after embedding. We further show that the shrinkage of slices is not uniform and artifacts in morphology and anatomical parameters produced cannot be compensated using linear correction algorithms. Our study, thus, emphasizes the importance of preventing the deformation of slice preparations and offers an effective means for reducing shrinkage and associated artifacts during embedding.
Designed Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4+ T cells to reduce the latent HIV+ cell reservoir
Authors: Patasic Lea , Seifried Janna , Bezler Valerie , Kaljanac Marcell , Schneider Irene C. , Schmitz Heike , Tondera Christiane , Hartmann Jessica , Hombach Andreas , Buchholz Christian J. , Abken Hinrich , König Renate , Cichutek Klaus 
Published: September 2020

AbstractChimeric Antigen Receptor (CAR)-redirected T cells show great efficacy in the patient-specific therapy of hematologic malignancies. Here, we demonstrate that a DARPin with specificity for CD4 specifically redirects and triggers the activation of CAR engineered T cells resulting in the depletion of CD4+ target cells aiming for elimination of the human immunodeficiency virus (HIV) reservoir.
Urine collection methods and dipstick testing in non-toilet-trained children
Authors: Diviney James , Jaswon Mervyn S. 
Published: September 2020

AbstractUrinary tract infection is a commonly occurring paediatric infection associated with significant morbidity. Diagnosis is challenging as symptoms are non-specific and definitive diagnosis requires an uncontaminated urine sample to be obtained. Common techniques for sampling in non-toilet-trained children include clean catch, bag, pad, in-out catheterisation and suprapubic aspiration. The pros and cons of each method are examined in detail in this review. They differ significantly in frequency of use, contamination rates and acceptability to parents and clinicians. National guidance of which to use differs significantly internationally. No method is clearly superior. For non-invasive testing, clean catch sampling has a lower likelihood of contamination and can be made more efficient through stimulation of voiding in younger children. In invasive testing, suprapubic aspiration gives a lower likelihood of contamination, a high success rate and a low complication rate, but is considered painful and is not preferred by parents. Urine dipstick testing is validated for ruling in or out UTI provided that leucocyte esterase (LE) and nitrite testing are used in combination.
The Curinga–Girifalco Line in the framework of the tectonic evolution of the remnant Alpine chain in Calabria (southern Italy)
Authors: Festa Vincenzo , Cicala Marianna , Tursi Fabrizio 
Published: September 2020

AbstractIn the peri-Mediterranean metamorphic belts, the tectonic evolution of the Calabria–Peloritani terrane during the dominant compressive tectonics of the Eocene represents one of the most problematic points in palinspastic restorations. A matter of particular debate is its shortening, which could have occurred during the Alpine or the Apennine subduction. In this regard, a crucial joint is provided by the kinematics of one of the most relevant shear zones such as the Curinga–Girifalco Line, cropping out in central Calabria. This shear zone juxtaposed a nearly complete Hercynian crustal section (i.e. the Sila and Serre Unit) onto the remnants of the Castagna Unit. The data in the available literature on ductile kinematics from the south-eastern branch of the Curinga–Girifalco Line indicate a downward movement of the hanging wall. In the present paper we show new, ductile kinematic data and petrographic evidence from outcrops in the north-western and south-eastern branches of the Curinga–Girifalco Line. Our results highlight the coherent kinematics of the Eocene shortening during the Alpine subduction system, followed by (late Eocene?)Oligocene to early Miocene, dominantly ductile extensional reworking, relating to the Apennines subduction system.
Is dopaminergic medication dose associated with self-reported bruxism in Parkinson’s disease? A cross-sectional, questionnaire-based study
Authors: Verhoeff M. C. , Koutris M. , van Selms M. K. A. , Brandwijk A. N. , Heres M. S. , Berendse H. W. , van Dijk K. D. , Lobbezoo F. 
Published: September 2020

Abstract
Objectives
It is not clear whether dopaminergic medication influences bruxism behaviour in patients with Parkinson’s disease (PD). Therefore, the aims are to investigate (i) the prevalence of possible (i.e., self-reported) bruxism (sleep and awake) in PD patients, and (ii) whether the use of dopaminergic medication and other factors (viz., demographic characteristics, PD-related factors, and possible consequences of bruxism) are associated with possible bruxism (sleep or awake).

Materials and methods
This study concerns a secondary analysis of an earlier published study. Three hundred ninety-five PD patients (67.9 ± 8.6 years of age; 58.7% males) were included. The levodopa equivalent daily dosage (LEDD) was used as a measure of the dopaminergic medication level. Subsequently, a logistic regression analysis was performed for the dependent variables ‘awake bruxism’ and ‘sleep bruxism’, with the following predictors: gender, age, LEDD, time since PD diagnosis, temporomandibular disorder (TMD) pain, jaw locks, and tooth wear.

Results
The prevalence of possible awake and sleep bruxism was 46.0% and 24.3%, respectively. Awake bruxism was associated with sleep bruxism (OR = 8.52; 95% CI 3.56–20.40), TMD pain (OR = 4.51; 95% CI 2.31–8.79), and tooth wear (OR = 1.87; 95% CI 1.02–3.43). Sleep bruxism was associated with tooth wear (OR = 12.49; 95% CI 4.97–31.38) and awake bruxism (OR = 9.48; 95% CI 4.24–21.19). Dopaminergic medication dose was not associated with awake bruxism (OR = 1.0; 95% CI 0.99–1.00) or sleep bruxism (OR = 1.0; 95% CI 0.99–1.00).

Conclusion
Bruxism is a common condition in PD patients, but is not associated with the dopaminergic medication dose.

Clinical relevance
(Oral) health care providers should be alerted about the possibility of sleep and awake bruxism activity in PD patients, along with this activity’s possible negative health outcomes (viz., TMD pain, tooth wear).
Mental health and well-being from childhood to adulthood: design, methods and results of the 11-year follow-up of the BELLA study
Authors: Otto Christiane , Reiss Franziska , Voss Catharina , Wüstner Anne , Meyrose Ann-Katrin , Hölling Heike , Ravens-Sieberer Ulrike 
Published: September 2020

AbstractMental health and well-being are of great interest in health policy and research. Longitudinal surveys are needed to provide solid population-based data. We describe the design and methods of an 11-year follow-up of the German BELLA study in children, adolescents and young adults, and we report on age- and gender-specific courses of general health and well-being, long-term health-related outcomes of mental health problems, and mental health care use. The BELLA study is the module on mental health and well-being within the German Health Interview and Examination Survey for Children and Adolescents (KiGGS). Standardised measures were used at each of the five measurement points of the BELLA study. In the 11-year follow-up, young people aged 7–31 years participated (n = 3492). Individual growth modelling, linear regression and descriptive analyses were conducted. Self-reported general health and well-being were both better in younger (vs. older) and in male (vs. female) participants according to the data from all five measurement points. Mental health problems in childhood and adolescence (measured at baseline) predicted impaired health outcomes at 6-year and 11-year follow-ups. Approximately one out of four children with a diagnosed mental disorder was not undergoing mental health treatment. With its 11-year follow-up, the prospective longitudinal BELLA study provides new and solid data on mental health and well-being from childhood to adulthood in Germany, and these data are important for health promotion and prevention practices. These results are consistent with previous findings. Promising future analyses are planned.
Primary decompressive craniectomy in poor-grade aneurysmal subarachnoid hemorrhage: long-term outcome in a single-center study and systematic review of literature
Authors: Brandecker Simon , Hadjiathanasiou Alexis , Kern Tamara , Schuss Patrick , Vatter Hartmut , Güresir Erdem 
Published: September 2020

AbstractPrimary decompressive craniectomy (PDC) in patients with poor-grade aneurysmal subarachnoid hemorrhage (aSAH) in order to decrease elevated intracranial pressure (ICP) is controversially discussed. The aim of this study was to analyze the effect of PDC on long-term clinical outcome in these patients in a single-center cohort and to perform a systematic review of literature. Eighty-seven consecutive poor-grade SAH patients (World Federation of Neurosurgical Societies (WFNS) grades IV and V) were analyzed between October 2012 and August 2017 at the author’s institution. PDC was performed due to clinical signs of herniation or brain swelling according to the treating surgeon. Outcome was analyzed according to the modified Rankin Scale (mRS). Literature was systematically reviewed up to August 2019, and data of poor-grade aSAH patients who underwent PDC was extracted for statistical analyses. Of 87 patients with poor-grade aSAH in the single-center cohort, 38 underwent PDC and 49 did not. Favorable outcome at 2 years post-hemorrhage did not differ significantly between the two groups (26% versus 20%). Systematic literature review revealed 9 studies: Overall, a favorable outcome could be achieved in nearly half of the patients (49%), with an overall mortality of 24% (median follow-up 11 months). Despite a worse clinical status at presentation (significantly higher rate of mydriasis and additional ICH), poor-grade aSAH patients with PDC achieve favorable outcome in a significant number of patients. Therefore, treatment and PDC should not be omitted in this severely ill patient collective. Prospective controlled studies are warranted.