bluuebunny/crossref_metadata_2025_split huggingface dataset:
TRPM3_miR-204: a complex locus for eye development and disease
Authors: Shiels Alan 
Published: February 2020

AbstractFirst discovered in a light-sensitive retinal mutant ofDrosophila, the transient receptor potential (TRP) superfamily of non-selective cation channels serve as polymodal cellular sensors that participate in diverse physiological processes across the animal kingdom including the perception of light, temperature, pressure, and pain. TRPM3 belongs to the melastatin sub-family of TRP channels and has been shown to function as a spontaneous calcium channel, with permeability to other cations influenced by alternative splicing and/or non-canonical channel activity. Activators of TRPM3 channels include the neurosteroid pregnenolone sulfate, calmodulin, phosphoinositides, and heat, whereas inhibitors include certain drugs, plant-derived metabolites, and G-protein subunits. Activation of TRPM3 channels at the cell membrane elicits a signal transduction cascade of mitogen-activated kinases and stimulus response transcription factors. The mammalian TRPM3 gene hosts a non-coding microRNA gene specifying miR-204 that serves as both a tumor suppressor and a negative regulator of post-transcriptional gene expression during eye development in vertebrates. Ocular co-expression of TRPM3 and miR-204 is upregulated by the paired box 6 transcription factor (PAX6) and mutations in all three corresponding genes underlie inherited forms of eye disease in humans including early-onset cataract, retinal dystrophy, and coloboma. This review outlines the genomic and functional complexity of the TRPM3_miR-204 locus in mammalian eye development and disease.
Variations in extreme wave events near a South Pacific Island under global warming: case study of Tropical Cyclone Tomas
Authors: Taniguchi Kenji , Tajima Yoshimitsu 
Published: February 2020

AbstractThe intensification of tropical cyclones (TCs) and wind-induced ocean waves is expected to be amplified under global warming conditions. In 2010, strong TC Tomas approached the Fiji Islands and caused severe damage. Here, an ensemble simulation technique is combined with a pseudo-global warming (PGW) method to investigate future variations in TCs and wind-induced ocean waves. Ensemble PGW simulations were implemented using the weather research and forecasting (WRF) model with five different future projections. Hindcast and PGW simulations showed similar tracks of Tomas. In four PGW simulations, the central pressures of the simulated TCs decreased. Enhanced near-surface wind was recognized in three PGW simulations around the Fiji main island (Viti Levu). In the other two future simulations, the surface wind speed was weaker than the one in the present climate because of the slight eastward shift in the track and delayed development of the TC. WaveWatchIII (WW3) was applied for offshore wave simulations forced by the wind field obtained by WRF simulation results. In three future simulations, a clear increase in the maximum significant wave height (Hs) was found on the southeastern coast of Viti Levu. One future simulation yielded almost the same offshore wave characteristics as those under the present climate. In another future simulation, the ensemble mean Hs was as high as that in the present climate, but extremely large Hs values were found in several ensemble members. Future simulations using multiple global climate model (GCM) projections showed possible variations in TCs and wind-induced ocean waves which is useful for the risk assessment of various hazards.
Histologic evaluation of femoral nerve demyelinating and axonal neuropathy in Wistar rats due to alendronate intake: a randomised study
Authors: Theodora Papamitsou , Apostolos Papakoulas , Vasileios Papaliagkas , Sofia Karachrysafi , Eva-Maria Dietrich , Antonia Sioga 
Published: February 2020

Abstract
Background
Bisphosphonates (BPs) are forceful inhibitors of osteoclast-mediated bone resorption. Long-term BP use is associated with multiple rare but severe adverse effects. The objective of this study was to investigate the possible effects of BPs in the structure of femoral nerve. Specimens from the femoral nerve of ten female 12-month old Wistar rats were used as control group and ten female 12-month old Wistar rats to which Alendronate (Fosamax, Merck) was administered per os for 13 weeks, were used as research group. Samples were observed under a Transmission Electron Microscope. G ratio measurements and statistical analysis with SPSS program were also performed.

Results
The control group showed no major changes of the nerve’s histologic image, with the exception of some spots of thickness of the nerve myelin sheath. The research group showed major morphological changes which varied from partial disorganization or thickening of the myelin to severe myelin thickening and axon strangulation. A statistically significant difference of the G ratio between the two groups was observed.

Conclusions
The reported values (found in literature) for the morphologic measurements of the femoral nerve in Wistar rats are not complying with the ones we found in our study. There was a significant reduction of all three variables (the mean axon like diameter, the myelin thickness, G ratio) studied in the femoral nerve of the research group in contrast to control group. Our study demonstrates a possible correlation between alendronate administration and femoral nerve’s function, nevertheless due to the small specimen further research is needed.
Risk factors for postoperative infection of odontogenic cysts associated with mandibular third molar
Authors: Kim Jin-woo , On Do-hyun , Cho Jin-yong , Ryu Jaeyoung 
Published: February 2020

Abstract
Background
Odontogenic cysts associated with lower third molar are common. The prognosis for surgical treatment is relatively good. However, postoperative infection discourages the clinicians. Hence, we would like to investigate the factors associated with infection after surgical treatment of cysts associated with the mandibular third molar.

Methods
We retrospectively reviewed the medical and radiographic records of 81 patients who were diagnosed with dentigerous cyst or odontogenic keratocyst and underwent cyst enucleation. The factors affecting postoperative infection were divided into host factor, treatment factor, and cystic lesion factor. To identify the factors associated with postoperative infection, we attempted to find out the variables with significant differences between the groups with and without infection.

Results
A total of 81 patients (64 male and 17 female) were enrolled in this study. There was no statistical relationship about the postoperative infection between all variables (gender, smoking, diabetes mellitus, age, bone grafting, related tooth extraction, previous marsupialization or decompression, type of antibiotics, cortical perforation associated with cystic lesion, preoperative infection, preoperative cyst size).

Conclusions
The results of this study suggest that it is not necessary to avoid bone grafts that are concerned about postoperative infection.
Timed immersion expiration measures in patients with muscular dystrophies
Authors: Voos Mariana Callil , Goya Priscila Santos Albuquerque , de Freitas Bruna Leal , Pires Aline Moço Teixeira , Favero Francis Meire , Caromano Fátima Aparecida 
Published: February 2020

Abstract
Introduction
Muscular dystrophies (MD) cause muscle weakness, affecting motor and respiratory functions. Aquatic activities maintain strength and ventilatory function and may require immersion expiration control.

Objectives
(1) To describe the evolution of timed immersion expiration in patients with MD in one-year follow-up. (2) to describe motor and respiratory outcomes in one-year follow-up. (3) to investigate possible relationships between timed immersion expiration and age, motor and respiratory functions.

Method
Fifty-seven patients with MD (12–35 years, Vignos scale 2–8) were evaluated twice, with one-year interval. Immersion expiration control was timed with a chronometer. Motor function was assessed by Motor Function Measure. The respiratory function was evaluated by spirometry. Analysis of variance compared assessments and Pearson tests investigated relationships between variables and age.

Results
Motor and respiratory functions decreased (p < 0.001) but timed immersion expiration was maintained. Timed immersion expiration was not correlated to motor and respiratory functions.

Conclusion
As patients maintained timed immersion expiration in the one-year follow-up, aquatic therapy might be a facilitator for people with MD.
Comparative study between sequential combined spinal epidural anesthesia versus epidural volume extension in lower limb surgery
Authors: Hakim Karim Youssef Kamal 
Published: February 2020

Abstract
Background
This randomized, double-blind study was designed to compare between sequential combined spinal epidural anesthesia versus epidural volume extension in lower limb surgery as regards hemodynamics, sensory, and motor blocks.

Methods
In this randomized, double-blind, prospective study, 80 patients scheduled for lower limb surgery were divided into two groups: sequential combined spinal epidural (SCSE) group in which small doses of local anesthetic was injected in epidural space after low-dose spinal anesthesia and epidural volume extension (EVE) group in which 10 ml saline was injected in epidural space after low-dose spinal anesthesia. Hemodynamics, anesthesia readiness time, degree of motor block, time to regression of sensory block, and side effects were measured.

Results
Hemodynamic changes were insignificant. Anesthesia readiness time was significantly faster in EVE group. Motor block and sensory block were better in SCSE. Postoperative bupivacaine consumption was statistically insignificant between the two groups.

Conclusion
Both SCSE and EVE techniques can preserve hemodynamics after low-dose subarachnoid block and can be used in high-risk elderly patients undergoing orthopedic surgery.
Large-scale application of case-based learning for teaching medical biochemistry: a challenging experience with positive impacts
Authors: Eissa Sanaa , Sallam Reem M. , Moustafa Amr S. , Hammouda Abdelrahman M. A. 
Published: February 2020

AbstractWith the introduction of integrated approach in the medical curriculum, there is a need to teach basic sciences in a way relevant to real clinical scenarios. The aim of this study is to investigate the feasibility of case-based learning (CBL) for teaching of medical biochemistry to a large number of medical students. It also evaluates both the students’ and faculty members’ perception of this approach. CBL was introduced in teaching medical biochemistry in the Neuroscience block for the second-year medical students. This study’s students were from two consecutive academic years (n = 721 and 769). Four clinical cases were prepared. Students were divided into subgroups, each having one CBL session every 2 weeks. Students were encouraged to work together to understand the given clinical scenario by building on past knowledge obtained through other teaching modalities and new knowledge acquired during the session. A pretest was administered at the beginning of the session, and an identical posttest administered at the end of the session. Perception of both the students and facilitators of the CBL-teaching approach was evaluated using end-of-block questionnaires. In both studied academic years, students got higher scores in posttest compared to pretest scores with a statistically significant difference of the paired scores (P < 0.001). Analysis of the students’ questionnaire demonstrated that most students positively perceived the CBL approach, with a feeling that CBL has helped them learning the biochemistry concepts. Likewise, analyzing staff questionnaire revealed staff’s positive attitude toward the impact of CBL in teaching biochemistry on the students and on themselves. The current work suggests that CBL is both feasible and efficient to be applied for teaching medical biochemistry on a large scale. It is positively perceived by both students and teaching staff. Future work is still needed to solve certain challenges such as increasing work load on the faculty members and to test the impact of this teaching modality on long-term retention of knowledge.
Representation of Black, Asian and minority ethnic patients in secondary care mental health services: analysis of 7-year access to memory services in Leicester and Leicestershire
Authors: Subramaniam Hari , Mukaetova-Ladinska Elizabeta B. , Wilson Andrew , Bankart John 
Published: February 2020

Aims and methodWe aimed to explore access by Black, Asian and minority ethnic (BAME) elders to the memory services in Leicester and Leicestershire, examining any trends over time. We then compared the odds of referral by ethnicity, using observed versus expected referrals for the city of Leicester. We gathered data on a comprehensive county-wide memory clinic used by people with suspected dementia and memory problems from the Trust electronic record system during the period 2011–2017. For Leicester city, we compared referral rates for 2011–2017 and compared observed and expected referral rates with demographics from the UK Census 2011.ResultsIn Leicester, there was a significant underrepresentation of referrals from the BAME population as compared with the White population in 2011, 2012 and 2013, when compared with population estimates of those aged ≥60 years from the 2011 UK Census Leicester city data. Data for the Black population were too small for comparisons. The odds of being referred to a memory clinic for the White group was double that of the Asian group in 2011 (odds ratio 2.15, 95% CI 1.52–3.02) and nearly 1.5 times in 2012 (odds ratio 1.40, 95% CI 1.01–1.93). This difference did not persist after 2014. However, this differential odds of referral changes when the age difference between the groups is accounted for. After adjusting for age, there were no differences between the two groups in their odds of referral to the memory clinic from 2011 to 2013, but from 2014 to 2017, members of the Asian group had higher odds of being referred.Clinical implicationsThe relationship between BAME and access to memory services is complex. The relative lower prevalence of Asian people among referrals to memory services in Leicester from 2011 to 2013 may partly be explained by the lower ages of the Asian population at referral. The higher prevalence of Asian people in 2014–2017 may be owing to use of denominators from the 2011 UK Census, which are likely to be disproportionately low for this group. Further studies are needed to explore any potential barriers to the access of services by BAME communities.
Association Between Delivery System Structure and Intensity of End-of-Life Cancer Care
Authors: Herrel Lindsey A. , Zhu Ziwei , Griggs Jennifer J. , Kaye Deborah R. , Dupree James M. , Ellimoottil Chandy S. , Miller David C. 
Published: February 2020

PURPOSE: To determine whether the type of delivery system is associated with intensity of care at the end of life for Medicare beneficiaries with cancer. PATIENTS AND METHODS: We used SEER registry data linked with Medicare claims to evaluate intensity of end-of-life care for patients who died of one of ten common cancers diagnosed from 2009 through 2014. Patients were categorized as receiving the majority of their care in an integrated delivery system, designated cancer center, health system that was both integrated and a certified cancer center, or health system that was neither. We evaluated adherence to seven nationally endorsed end-of-life quality measures using generalized linear models across four delivery system types. RESULTS: Among 100,549 beneficiaries who died of cancer during the study interval, we identified only modest differences in intensity of end-of-life care across delivery system structures. Health systems with no cancer center or integrated affiliation demonstrated higher proportions of patients with multiple hospitalizations in the last 30 days of life (11.3%), death in an acute care setting (25.9%), and lack of hospice use in the last year of life (31.6%; all P < .001). Patients enrolled in hospice had lower intensity care across multiple end-of-life quality measures. CONCLUSION: Intensity of care at the end of life for patients with cancer was higher at delivery systems with no integration or cancer focus. Maximal supportive care delivered through hospice may be one avenue to reduce high-intensity care at the end of life and may impact quality of care for patients dying from cancer.
Evaluasi Psikometris General Health Questionnaire (GHQ) 28 Pada Subjek Mahasiswa di Semarang, Jawa Tengah
Authors: Syafitri Diany Ufieta 
Published: February 2020

Abstrak: usia remaja hingga dewasa dianggap sebagai masa yang rentan terhadap masalah kesehatan mental. Dilaporkan dalam berbagai berita maupun penelitian mahasiswa juga merupakan segmen memiliki kemungkinan tinggi mengalami masalah kesehatan mental. Salah satu hambatan utama dalam penanganan kesehatan mental di Indonesia adalah kurangnya alat skrining kesehatan mental yang adekuat. Telah terdapat beberapa alat skrining tetapi tidak disertai dengan informasi tentang evaluasi psikometris yang memadai. Penelitian ini bertujuan untuk mengevaluasi properti psikometris alat skrining General Health Questionnaire (GHQ) 28 yang sebelumnya telah diadaptasi ke dalam bahasa Indonesia untuk melihat apakah alat ini memiliki reliabilitas dan validitas yang memadai sebagai alat skrining dan memiliki faktor struktur yang sesuai dengan acuan teoretisnya. Subjek penelitian ini adalah 356 mahasiswa S1 dari berbagai universitas di Kota Semarang. Hasilnya, didapatkan koefisien reliabiliatas Alpha Cronbach 0,897 yang dianggap memuaskan. Hasil analisis faktor menunjukkan terdapat empat faktor sesuai dengan faktor asli penyusun GHQ 28. Secara umum, GHQ 28 versi terjemahan bahasa Indonesia memiliki properti psikometris yang cukup baik. Kata kunci: evaluasi psikometris, General Health Questionnaire, kesehatan mental, mahasiswa
Fatherhood dan Indeks Prestasi (IP) Akademik pada Mahasiswa Fakultas Pendidikan Psikologi, Universitas Negeri Jakarta
Authors: Hutomo Bijak Aditia , Jannah Fathimah Miftahul , Latifah Tahlia 
Published: February 2020

Abstrak: Pendidikan merupakan salah satu hal mendasar yang sangat dibutuhkan oleh manusia, sama halnya dengan pengasuhan orangtua. Sebagai bagian dari pendidikan, mahasiswa merupakan seseorang yang berada dalam tahapan perkembangan remaja menuju dewasa awal. Dalam beberapa teori, remaja lebih cenderung terlibat dengan teman sebaya daripada orangtuanya. Keterlibatan yang lebih pada teman sebaya tidak berarti remaja tidak terlibat secara seutuhnya dengan orang tuanya. Penelitian ini merupakan penelitian deskriptif kuantitatif yang bertujuan mencari gambaran Fatherhood dan Indeks Prestasi Akademik pada Mahasiswa Fakultas Pendidikan Psikologi, Universitas Negeri Jakarta. Literatur lain menunjukkan bahwa keterlibatan ayah memiliki kontribusi yang sangat besar pada prestasi akademik anak usia 13-15 tahun. Alat ukur yang digunakan dalam penelitian ini adalah The Fatherhood Scale yang dikembangkan oleh Gary L. Dick pada tahun 2016. Populasi dan Sampel dari penelitian ini adalah mahasiswa Fakultas Pendidikan Psikologi angkatan 2016 dan 2017. Hasil dari penelitian ini diharapkan mampu menjadi gambaran sederhana mengenai bagaimana Fatherhood dan Indeks Prestasi (IP) Akademik yang ada pada mahasiswa. Keyword: Fatherhood, Mahasiswa, Indeks Prestasi Akademik
Energy Resource of Charcoals Derived from Some Tropical Fruits Nuts Shells
Authors: Kongnine Damgou Mani , Kpelou Pali , Attah N’Gissa , Kombate Saboilliè , Mouzou Essowè , Djeteli Gnande , Napo Kossi 
Published: February 2020

This work was focused on carbonizing four tropical fruits shells wastes such as: coconut shells (CS), palmyra shells (PS), doum palm shells (DPS), whole fruit of doum palm (WFDP) and teak wood (TW) used as control. The aim was to investigate the potential of those biochar to be used as an alternative energy source in replacement ofcharcoal. The raw biomasses samples were carbonized under the same conditions and some combustion characteristics of the obtained biochar such as lower calorific value, energy per unit volume associated to bulk density, ash content, moisture content and ash mineral content were investigated. The temperature in the furnace was estimated during carbonization process using a K-type thermocouple. The thermal profile of the studied raw biomasses reveals three phases of carbonization. The biochar yield drops significantly for all biomasses as the final maximum temperature increases. The average yields obtained ranged from 37.81 % for palmyra shells to 27.57 % for the doum palm shells. The highest yield achieved was 42.32 % obtained at 280 °C for palmyra shells, the lowest yield (24.42 %) was recorded at the highest maximum temperature of 590 ° C for doum palm shells. The results of energy parameters of the studied biochar showed that coconut shells charcoal presented the highest lower calorific value (28.059 MJ.kg-1), followed by doum palm shells (26.929 MJ.kg-1) when, with 25.864 MJ.kg-1, whole fruit of doum palm charcoal showed the lowest lower calorific value. Similarly, with the highest bulk density of 0.625 g/cm3 coconut shells charcoal presented the highest energy per unit volume (17536.88 J/cm3), whereas with the lowest bulk density of 0.415 g/cm3, whole fruit of doum palm charcoal presented the lowest energy per unit volume. The ash content analysis showed that whole fruit of doum palm had the highest ash content (18.75 %) and palmyra nut shells charcoal (8.42 %).Teak wood charcoal, took as control, has the highest lower calorific value (32.163 MJ.kg-1), less dense as coconut shell (0.43 g/cm3), his energy per unit of volume is 13830.09 j/cm3 but the lowest value of as content (2.90 %). Among these biomasses charcoals, only whole fruit of doum palm charcoal ash showed a high chloride and sulfide content respectively 9.73 % and 1.75 % in weight. From these results, the produced charcoals could be used as alternative fuels except for whole fruits of doum palm charcoal which chloride and sulfide content were found high. ©2020. CBIORE-IJRED. All rights reserved
Winter wheat growing in Ukraine: ecological assessment of technologies by the influence on soil fertility
Authors: BONDAR Lera , MAKARENKO Nataliia 
Published: February 2020

Modern technologies of winter wheat growing need to be improved taking into account the results of ecological evaluation of their impact on soil fertility indices. We aimed to assess the technologies of winter wheat growing in different soil and climatic conditions of Ukraine by their influence on soil fertility. It is known that in order to estimate ecological safety of crop growing technologies, it is advisable to use a method based on identifying negative impacts on soil fertility. We propose the group of deviation values from the optimum as follows: (i) strong, which leads to an unsatisfactory ecological condition (˃ 50 %), (ii) average that provides a satisfactory state (˃ 25 %, but ˂ 50 %), (iii) moderate, which provides a normal state (≤ 10 %, but ˂ 25 %), (iv) absent, an optimal condition is provided (˂ 10 %). It is revealed that technologies of winter wheat growing in the conditions of Polissya, Forest-steppe and Steppe Zones of Ukraine can have a negative influence on potassium regime in soils, the influence by intensity can vary from moderate to strong. In Polissya and Forest-steppe, winter wheat growing can lead to deterioration of soil pH status. In Steppe, along with the potassium regime, the technologies can negatively influence soil nitrogen status and the effect may be characterized as strong.