bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case of Ischemic Stroke Incidental to the Postelectroconvulsive Therapy Period
Authors: Shahin Hazem , Livingston Robin 
Published: February 2020

Abstract
Electroconvulsive therapy (ECT) is a routine treatment for multiple psychiatric disorders including treatment-refractory mood and psychotic disorders. Although ECT is generally a safe and well-tolerated intervention, rare cerebrovascular and cardiovascular complications have been reported. The hemodynamic changes during the ECT seizure are well-recognized, with an initial parasympathetically mediated decrease in heart rate and blood pressure followed by a sympathetically mediated increase in these parameters. Despite intraoperative or postoperative blood pressure fluctuations, the risk of a hypertensive intracerebral bleed during ECT is very low and the risk of ischemic stroke after ECT appears to be even rarer. The authors present a case of a patient who developed an ischemic stroke after ECT treatment. Before stroke, the patient had been undergoing ECT routinely for over 2 years without alarming complications. Ischemic strokes are a rare but serious complication of ECT treatment.
Mobile genomics: tools and techniques for tackling transposons
Authors: O'Neill Kathryn , Brocks David , Hammell Molly Gale 
Published: February 2020

Next-generation sequencing approaches have fundamentally changed the types of questions that can be asked about gene function and regulation. With the goal of approaching truly genome-wide quantifications of all the interaction partners and downstream effects of particular genes, these quantitative assays have allowed for an unprecedented level of detail in exploring biological interactions. However, many challenges remain in our ability to accurately describe and quantify the interactions that take place in those hard to reach and extremely repetitive regions of our genome comprised mostly of transposable elements (TEs). Tools dedicated to TE-derived sequences have lagged behind, making the inclusion of these sequences in genome-wide analyses difficult. Recent improvements, both computational and experimental, allow for the better inclusion of TE sequences in genomic assays and a renewed appreciation for the importance of TE biology. This review will discuss the recent improvements that have been made in the computational analysis of TE-derived sequences as well as the areas where such analysis still proves difficult.
This article is part of a discussion meeting issue ‘Crossroads between transposons and gene regulation’.
DRT111/SFPS splicing factor controls ABA sensitivity in Arabidopsis seed development and germination
Authors: Punzo Paola , Ruggiero Alessandra , Possenti Marco , Perrella Giorgio , Nurcato Roberta , Costa Antonello , Morelli Giorgio , Grillo Stefania , Batelli Giorgia 
Published: February 2020

AbstractRNA splicing is a fundamental mechanism contributing to the definition of the cellular protein population in any given environmental condition. DRT111/SFPS is a splicing factor previously shown to interact with phytochromeB and characterized for its role in splicing of pre-mRNAs involved in photomorphogenesis. Here, we show that DRT111 interacts with Arabidopsis Splicing Factor 1 (SF1), involved in 3’ splicing site recognition. Double and triple mutant analysis shows that DRT111 controls splicing ofABI3and acts upstream of the splicing factor SUPPRESSOR OF ABI3-5 (SUA).DRT111is highly expressed in seeds and stomata ofArabidopsisand is induced by long-term treatments with polyethylene glycol and ABA.DRT111knock-out mutants are defective in ABA-induced stomatal closure and are hypersensitive to ABA during seed germination. Conversely,DRT111over-expressing plants show ABA hyposensitive seed germination. RNAseq experiments show that in dry seeds,DRT111controls expression and splicing of genes involved in response to osmotic stress and ABA, light signaling and mRNA splicing, including targets of ABSCISIC ACID INSENSITIVE3 (ABI3) and PHYTOCHROME INTERACTING FACTORs (PIFs). Consistently, expression of the germination inhibitorSOMNUS,induced by ABI3 and PIF1 is up-regulated in imbibed seeds ofdrt111-2mutants. Altogether, these results indicate thatDRT111controls sensitivity to abscisic acid (ABA) during seed development, germination and stomatal movements and constitutes a point of integration of the ABA- and light-regulated pathways to control seed germination.One Sentence SummaryArabidopsis splicing factorDRT111/SFPSis required for ABA-mediated responses in seeds
Distinct Hierarchical Alterations of Intrinsic Neural Timescales Account for Different Manifestations of Psychosis
Authors: Wengler Kenneth , Goldberg Andrew T. , Chahine George , Horga Guillermo 
Published: February 2020

AbstractHierarchical perceptual-inference models of psychosis may provide a holistic framework for understanding psychosis in schizophrenia including heterogeneity in clinical presentations. Particularly, hypothesized alterations at distinct levels of the perceptual-inference hierarchy may explain why hallucinations and delusions tend to cluster together yet sometimes manifest in isolation. To test this, we used a recently developed resting-state fMRI measure of intrinsic neural timescale (INT), which reflects the time window of neural integration and captures hierarchical brain gradients. In analyses examining extended sensory hierarchies that we first validated, we found distinct hierarchical INT alterations for hallucinations versus delusions in the auditory and somatosensory systems, thus providing support for hierarchical perceptual-inference models of psychosis. Simulations using a large-scale biophysical model suggested local elevations of excitation-inhibition ratio at different hierarchical levels as a potential mechanism. More generally, our work highlights the robustness and utility of INT for studying hierarchical processes relevant to basic and clinical neuroscience.
Mathematical Model of Colorectal Cancer Initiation
Authors: Paterson Chay , Clevers Hans , Bozic Ivana 
Published: February 2020

ABSTRACTQuantifying evolutionary dynamics of cancer initiation and progression can provide insights into more effective strategies of early detection and treatment. Here we develop a mathematical model of colorectal cancer initiation through inactivation of two tumor suppressor genes and activation of one oncogene, accounting for the well-known path to colorectal cancer through loss of tumor suppressorsAPCandTP53, and gain of theKRASoncogene. In the model, we allow mutations to occur in any order, leading to a complex network of incomplete mutational genotypes on the way to colorectal cancer. We parametrize the model using experimentally measured parameter values, many of them only recently available, and compare its predictions to epidemiological data on colorectal cancer incidence. We find that the reported incidence of colorectal cancer can be recovered using a mathematical model of colorectal cancer initiation together with experimentally measured mutation rates in colorectal tissues and proliferation rates of premalignant lesions. We demonstrate that the order of driver events in colorectal cancer is determined by the combined effect of the rates at which driver genes are mutated and the fitness effects they provide. Our results imply that there may not be significant immune suppression of untreated benign and malignant colorectal lesions.
Transcriptome-wide analysis of expressed resistance gene analogs (RGAs) in mango
Authors: Lantican Darlon V. , Cortaga Cris Q. , Manohar Anand Noel C. , dela Cueva Fe M. , Sison Maria Luz J. 
Published: February 2020

AbstractMango is an economically important fruit crop largely cultivated in the (sub)tropics and thus, is constantly challenged by a myriad of insect pests and diseases. Here, we identified and characterized the resistance gene analogs (RGAs) of mango fromde novoassembly of transcriptomic sequences. A core RGA database of mango with 747 protein models was established and classified based on conserved domains and motifs: 53 nucleotide binding site proteins (NBS); 27 nucleotide binding site-leucine rich repeat proteins (NBS-LRR); 17 coiled-coil NBS-LRR (CNL); 2 toll/interleukin-1 receptor NBS-LRR (TNL); 29 coiled-coil NBS (CN); 4 toll/interleukin-1 receptor NBS (TN); 17 toll/interleukin-1 receptor with unknown domain (TX); 158 receptor-like proteins (RLP); 362 receptor-like kinases (RLK); 72 transmembrane coiled-coil domain protein (TM-CC), and 6 NBS-encoding proteins with other domains. The various molecular functions, biological processes, and cellular localizations of these RGAs were functionally well-annotated through gene ontology (GO) analysis, and their expression profiles across different mango varieties were also determined. Phylogenetic analysis broadly clustered the core RGAs into 6 major clades based on their domain classification, while TM-CC proteins formed subclades all across the tree. The phylogenetic results suggest highly divergent functions of the RGAs which also provide insights into the mango-pest co-evolutionary arms race. From the mango RGA transcripts, 134 unique EST-SSR loci were identified, and primers were designed targeting these potential markers. To date, this is the most comprehensive analysis of mango RGAs which offer a trove of markers for utilization in resistance breeding of mango.
Beyond range size: drivers of species’ geographic range structure in European plants
Authors: Csergő Anna M. , Broennimann Olivier , Guisan Antoine , Buckley Yvonne M. 
Published: February 2020

AbstractAimTo assess if and how species’ range size relates to range structure, if the observed geographic range properties can be retrieved from predicted maps based on species distribution modeling, and whether range properties are predictable from biogeophysical factors.LocationEuropeTime periodCurrentMajor taxa studied813 vascular plant species endemic to EuropeMethodsWe quantified the size and spatial structure of species’ geographic ranges and compared ranges currently occupied with those predicted by species distribution models (SDMs). SDMs were constructed using complete occurrence data from the Atlas Florae Europaeae and climatic, soil and topographic predictors. We used landscape metrics to characterize range size, range division and patch shape structure, and analysed the phylogenetic, geographic and ecological drivers of species’ range size and structure using phylogenetic generalized least squares (pGLS).ResultsRange structure metrics were mostly decoupled from species’ range size. We found large differences in range metrics between observed and predicted ranges, in particular for species with intermediate observed range size and occupied area, and species with low and high observed patch size distribution, geographic range filling, patch shape complexity and geographic range fractality. Elevation heterogeneity, proximity to continental coasts, Southerly or Easterly geographic range positions and narrow ecological niche breadth constrained species’ observed range size and range structure to different extents. The strength and direction of the relationships differed between observed and predicted ranges.Main conclusionsSeveral range structure metrics, in addition to range size, are needed to adequately describe and understand species’ ranges. Species’ range structure can be well explained by geophysical factors and species niche width, albeit not consistently for observed and predicted ranges. As range structure can have important ecological and evolutionary consequences, we highlight the need to develop better predictive models of range structure than provided by current SDMs, and we identify the kinds of species for which this is most necessary.
Trichinella spiralissecretes abundant unencapsulated small RNAs with potential effects on host gene expression
Authors: Taylor Peter J. , Hagen Jana , Faruqu Farid N. , Al-Jamal Khuloud T. , Quigley Bonnie , Beeby Morgan , Selkirk Murray E. , Sarkies Peter 
Published: February 2020

AbstractMany organisms, including parasitic nematodes, secrete small RNAs into the extracellular environment largely encapsulated within small vesicles. Parasite secreted material often contains microRNAs (miRNAs), raising the possibility that they might contribute to pathology by regulating host genes in target cells. Here we characterise material from the parasitic nematodeTrichinella spiralisat two different life stages. We show that adultT. spiralis, which inhabit intestinal mucosa, secrete miRNAs within vesicles. Unexpectedly however,T. spiralismuscle stage larvae (MSL), which live intracellularly within skeletal muscle cells, secrete miRNAs that appear not to be encapsulated. Notably, secreted miRNAs include a homologue of mammalian miRNA-31, which has an important role in muscle development. Our work therefore suggests a new potential mechanism of RNA secretion with implications for the pathology ofT. spiralisinfection.
Factors influencing consumers' rejection to smartphone transactions in the lodging industry
Authors: Bae Stephanie , Mo Kwon Jun , Bosley Alyssa 
Published: February 2020

PurposeThe main purpose of this study is to investigate what affects a customer's decision to use the hotel smartphone applications when he/she makes a room reservation.Design/methodology/approachA total of 266 usable data was collected through an online survey. The research model was tested using confirmatory factor analyses and structural equation modeling.FindingsThis study revealed that perceived usefulness, perceived credibility, perceived equipment risk, and perceived change risk affected customers' intention to book a hotel room using hotel smartphone apps. Perceived ease of use did not have a significant effect on behavioral intention.Originality/valueThis study extended TAM and the existing literature of mobile technology in the lodging industry. This article explored both existing variables and new variables in studying customers' intention to use hotel smartphone apps when booking a hotel room.
Measuring hotel employee perceived job risk: dimensions and scale development
Authors: Xie Chaowu , Zhang Jiangchi , Chen Yanying , Morrison Alastair M. , Lin Zhibin 
Published: February 2020

Purpose
The main purpose of this study is to identify the dimensions of hotel employees’ job risk perceptions and develop a measurement scale for this construct.

Design/methodology/approach
Four studies using a mixed-method design were conducted to develop and validate the scale of hotel employees’ perceived job risk (HEPJR). Study 1 identified the dimensions and initial items of HEPJR through a literature review and in-depth interviews. In Study 2, an explanatory factor analysis was perform to refine the preliminary items. Study 3 further refined the HEPJR scale through a confirmatory factor analysis. Study 4 confirmed that HEPJR is a 19-item scale through a cross-validation analysis.

Findings
A reliable and valid scale was developed to measure the following five dimensions of HEPJR: perceived human, equipment, internal environment, external environment and management risks. HEPJR and its dimensions significantly predict negative safety consequences and negative job satisfaction.

Research limitations/implications
Employees in medium- and high-star-rated hotels in China were surveyed. Future research should test the HEPJR scale in other types of lodging formats (e.g. budget hotels, homestays and cruise ships) and different countries or regions.

Practical implications
Given the increasingly serious job risks faced by hotel employees, the HEPJR scale can become a benchmark for job risk identification, accident prevention and safety management.

Originality/value
This scale provides a clear conceptualization and an appropriate measurement tool of HEPJR from a risk-source perspective.
Ensuring volunteer impacts, legacy and leveraging is not “fake news”
Authors: Dickson Tracey J. , Darcy Simon , Pentifallo Gadd Caitlin 
Published: February 2020

PurposeThis study aims to explore the legacy potential of the FIFA Women’s World Cup (FWWC) 2015, for the host communities across Canada.Design/methodology/approachThe mixed-methods study included a link to an online anonymous survey being sent to all volunteers at the FWWC that explored their prior volunteering experience, motivations for volunteering, perceived skill development and future volunteering intentions. Documents were reviewed, and key stakeholders were interviewed.FindingsThe results support previous research that mega-sport event (MSE) volunteers are typically older females with prior volunteering experience. Those most likely to indicate they wanted to volunteer more are younger volunteers without prior volunteering experience. While legacy was discussed as a desired outcome, this was not operationalised through strategic human resource strategies such as being imbedded in the position descriptions for the volunteer managers.Research limitations/implicationsAs this study was conducted in the real-world context of a sport event, the timing of the survey was determined by the organising committee.Practical implicationsMega sport events typically draw upon existing host-city social and human capital. For future event organising committees planning for and delivering a volunteer legacy may require better strategic planning and leveraging relationships with existing host-city volunteer networks. In the context of a single sport, women’s MSE, multi-venue, multi-province event, greater connection was required to proactively connect younger women for volunteers to their geographic sport and event volunteering infrastructure.Originality/valueThis is the first research of volunteers for the largest women’s mega single-sport event. There are three theoretical contributions of the paper to: the socio-ecological lens, motivational theory of single event MSE and the contribution of social and human capital to understandings of legacy.
Authentic leadership and employees’ emotional labour in the hospitality industry
Authors: Wang Zhenyuan , Xie Yunhui 
Published: February 2020

PurposeThis study investigates the effect of authentic leadership on service employees’ emotional labour strategies, surface acting and deep acting, from a human energy perspective.Design/methodology/approachA three-wave survey was conducted in a hotel chain in China, and 347 valid responses were obtained. Mplus software was used for structural equation modelling and bootstrapping analysis.FindingsThis study finds the following: authentic leadership predicts service employees’ emotional labour strategies; job insecurity mediates the influence of authentic leadership on surface acting but not on deep acting; relational energy mediates both surface and deep acting; and relational energy has more negative (positive) indirect effects than job insecurity.Practical implicationsThe findings provide hospitality managers with insights into how to improve service employees’ capacity for emotional regulation. Hospitality managers should show more authenticity, pay attention to subordinates’ energy level and select and recruit candidates with positive energy traits. Hospitality organisations should encourage, select and train managers to behave as authentic leaders.Originality/valueThis study links authentic leadership with service employees’ emotional management in the hospitality industry. Moreover, it demonstrates the energising function of authentic leadership and introduces the new perspective of human energy to emotional labour research.
Sensory inputs in tourists’ nightlife experiences – a study of Bangkok, Kuala Lumpur and Singapore
Authors: Nghiêm-Phú Bình 
Published: February 2020

PurposeThis study aims to identify the sensory inputs that tourists use to shape their nightlife experiences.Design/methodology/approachThe situations in three Southeast Asian cities, Bangkok, Kuala Lumpur and Singapore were examined, using tourist reviews posted on tripadvisor.com. A total of 460 data units concerning Bangkok, 373 data units concerning Kuala Lumpur and 453 data units concerning Singapore were compiled and manually analyzed to reveal the frequency of the primary sensory inputs used by the reviewers. Bivariate correlation analysis was additionally performed to reveal the co-occurrences of the sensory inputs that tourists used to form their impressions of each city.FindingsThe findings suggest that gustatory inputs were powerful yet unspecific, while visual inputs were vivid and conspicuous. Audio inputs added certain meaningful contributions to some extent for some tourists. However, the distribution of the sensory inputs differed across the three cities. Moreover, the contributions of the olfactory and tactile inputs are largely missing.Practical implicationsWith the management of nightlife businesses (small or micro servicescapes), a thoughtful selection for the drink menu is necessary. When possible, a signature drink should be invented and promoted for each place. With the projection and promotion of tourist destinations as nightlifescapes, a sensory marketing approach should be considered. For example, nightlifescapes could be presented and promoted with unique drinks, good views of the city’s landmarks and interesting local music.Originality/valuePrior to this study, little research has been carried out to investigate tourists’ nightlife experiences and their impressions of nightlifescapes. In addition, little has been done to identify the sensory inputs that tourists use to explain their experiences and impressions.
Voluntary disclosure of accounting ratios and firm-specific characteristics: the case of GCC
Authors: Haddad Ayman E. , Baalbaki Shibly Fatima , Haddad Ruwaidah 
Published: February 2020

Purpose
The purpose of this study is to investigate the voluntary disclosure of accounting ratios in the corporate annual reports of manufacturing firms in the Gulf Cooperation Council (GCC) and determines whether an association exists between voluntary disclosure and firm-specific characteristics namely, size, profitability, leverage, liquidity and efficiency.

Design/methodology/approach
A sample of 53 GCC listed manufacturing firms and 263 firm-year observations were observed over the period 2011 to 2015. A count data regression (Poisson) with incident rate ratios was used to identify the relationship between firms’ voluntary disclosures of accounting ratios and other firm-specific characteristics.

Findings
During the period under review, the voluntary disclosure of accounting ratios provided in annual reports of GCC firms were found to be exceedingly low. On average, a GCC company discloses at most two accounting ratios in its annual reports. The results also show that the profitability ratios are the most popularly reported ones. Controlling for family board domination, the results also reveal that structure-related variables (firm size and leverage) are positively associated with accounting ratio disclosures. However, performance-related variables (profitability, liquidity and efficiency) have no significant effect on disclosures. The authors conclude that signaling theory as implied in the performance-related variables is not strongly supported in the GCC region.

Originality/value
This is the first known study to investigate the disclosure of accounting ratios and its determinants within the context of GCC. The findings of this study could be beneficial to both agents and principals in assessing the associated risks. The study provides regulators and market participants an understanding of the corporate reporting activities of manufacturing firms in the GCC and who accordingly will be able to consider associated policy implementation.