bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hyaluronan‐binding protein 1 (HABP1) overexpression triggers induction of senescence in fibroblasts cells
Authors: Vikramdeo Kunwar Somesh , Saha Paramita , Dutta Shubhra , Kumar Naveen , Roy Chowdhury Anindya , Kumar Sudhir , Tyagi Rakesh Kumar , Ghosh Ilora , Datta Kasturi 
Published: February 2020

AbstractHyaluronan‐binding protein 1 (HABP1), a multi‐compartmental, multi‐functional protein has a wide range of functions, which can be attributed to its ability to associate with a variety of cellular ligands. Earlier we have reported that HABP1 overexpression in rat normal fibroblasts (F‐HABP07) shows chronic generation of reactive oxygen species (ROS), induction of autophagy, and apoptosis. However, a significant proportion of cells remained viable after the majority went through apoptosis from 60 to 72 h. In this study, an attempt has been made to delineate the cellular events in the declined population of surviving cells. It has been elucidated here that, these cells at later time points of growth, that is, 72 and 84 h, not only appeared to shrink but also are devoid of autophagic vacuoles and displayed polyploidy. F‐HABP07 cells exhibited an altered cytoskeletal structure from their parental cell line F111, assumed to be caused upon inhibition of actin polymerization and decrease in IQ motif‐containing GTPase activating protein 1 (IQGAP1), a key protein associated with maintenance of cytoskeletal integrity. Enhanced expression and nuclear localization of AKT observed in F‐HABP07 cells appears to be contributing toward the maintenance of high ROS levels in these cells and also potentially modulating the IQGAP1 activity. These observations, in fact have been considered to result in sustained DNA damage, which then leads to increased expression of p53 and activation of p21 and carry out the cellular events responsible for senescence. Subsequent assessment of the presence of positive β‐gal staining and enhanced expression of p16INK4a in F‐HABP07, confirmed that HABP1 overexpressing fibroblasts undergo senescence.
Comparative effectiveness research applied to medical devices: Which PFO closure device is the best?
Authors: Won Hoyoun , Carroll John D. 
Published: February 2020

Key Points
Device‐to‐device comparisons are of interest and of potential practical value for clinicians.
The study design to achieve a high level of scientific evidence requires a prospective, multicenter, randomized trial with a large number of patients and addressing all important outcomes related to device effectiveness and safety.
The study by Fleming and coauthors comparing six different devices is provocative and interesting and has several virtues, but does not meet most of these standards, so readers should be cautious in deciding their device preferences.
A presumed case of Darbepoetin‐induced myocardial infarction in the patient with MDS‐RARS
Authors: Zafar Aneeqa Ahsan , Kouides Peter 
Published: February 2020

AbstractOur case is only the 2nd such reported case of atherothrombosis from ESAs and highlights the increased risk of cardiovascular events in patients receiving erythropoietin‐stimulating agents specially patients with underlying MDS where targeting a lower hemoglobin goal and optimizing other cardiovascular risk factors might be beneficial in preventing future cardiovascular mortality.
Overview of Synthetic Methods to Prepare Plasmonic Transition‐Metal Nitride Nanoparticles
Authors: Karaballi Reem A. , Monfared Yashar E. , Dasog Mita 
Published: February 2020

AbstractThe search for new plasmonic materials that are low‐cost, chemically and thermally stable, and exhibit low optical losses has garnered significant attention among researchers. Recently, metal nitrides have emerged as promising alternatives to conventional, noble‐metal‐based plasmonic materials, such as silver and gold. Many of the initial studies on metal nitrides have focused on computational prediction of the plasmonic properties of these materials. In recent years, several synthetic methods have been developed to enable empirical analysis. This review highlights synthetic techniques for the preparation of plasmonic metal nitride nanoparticles, which are predominantly free‐standing, by using solid‐state and solid–gas phase reactions, nonthermal and arc plasma methods, and laser ablation. The physical properties of the nanoparticles, such as shape, size, crystallinity, and optical response, obtained with such synthetic methods are also summarized.
Experimentelle Untersuchung zur Mehrphasenströmung in öleingespritzten Mehrphasenschraubenspindelpumpen
Authors: Lottis Marian , Deeb Mohammad , Luke Andrea 
Published: February 2020

AbstractFür die Förderung von Gemischen mit hohen Gasanteilen erfolgt die Entwicklung eines neuen Kühlkonzepts, indem das Prozessfluid in flüssiger Phase extern in die Förderkammer einer Mehrphasenpumpe eingespritzt wird. Neben der Regulierung des Thermomanagements trägt dies zur Spaltabdichtung bei, so dass der effektiv geförderte Volumenstrom steigt. Zur Untersuchung der Thermo‐ und Fluiddynamik einer solchen Mehrphasenpumpe wird ein transparentes Förderkammermodell der Pumpe mit externer Fluideinspritzung entwickelt. Das Förderkammermodell ermöglicht Experimente hinsichtlich der Fluiddynamik in den Spalten durch Variation der Anzahl und Richtung der Einspritzungen.
A coupled one dimension and transmission line model for arterial flow simulation
Authors: Baker Nathaniel , Clarke Richard , Ho Harvey 
Published: February 2020

AbstractA broad choice of numerical schemes and methods currently exists for blood flow simulations. The results rely critically on the prescription of boundary conditions. The outflow boundary condition for a one‐dimensional (1D) flow solver is usually prescribed via a Windkessel or lumped parameter model. The weakness of such an approach is the determination of the parameters. In the present work, we use an alternative approach, that is, a reflection coefficient (RC), to lumped parameter models for distal boundary conditions. With such a RC, the number of parameters required is reduced to one. We derive the theoretical foundation for the RC. Specifically, we couple a transmission line theory for peripheral resistance with a 1D arterial flow solver. We apply this method to a healthy and a stenosed virtual aorta, and show this method can reproduce some subtle features in arterial pressure propagation, such as the steepened pressure waveform and the reflection from the stenosed site. In summary, the RC parameter has strong physical implications in the theory of wave propagation and may be used in flow simulations where reflections need to be explicitly modeled.Novelty Statement
A novel coupled one‐dimensional‐transimission line model has been developed in this work with detailed implementations.
Only one outflow boundary condition, that is, the refection coefficient is required in the model.
Reflections for a pulse wave from aortic terminals as well as from a stenotic site are numerically simulated.
Unraveling complex traits in wheat: Approaches for analyzing genotype × environment interactions in a multienvironment study of falling numbers
Authors: Sjoberg Stephanie M. , Carter Arron H. , Steber Camille M. , Garland‐Campbell Kimberly A. 
Published: February 2020

AbstractMultienvironment trials provide useful information about highly variable, complex plant traits like yield and quality but are difficult to analyze due to their frequently unbalanced nature, with genotypes and locations varying from year to year. Our objective was to use multiple approaches, including joint regression and principal components analysis, to characterize patterns in the genotype × environment interactions across an unbalanced 3‐yr multienvironment wheat (Triticum aestivum L.) variety trial dataset, examining falling number (FN) test results in wheat. The FN test measures the decrease in flour gelling capacity resulting from starch digestion by the enzyme α‐amylase. Low FN and high‐α‐amylase grain is discounted because it is associated with poor end‐use quality. Low FN can be caused by susceptibility either to preharvest sprouting when it rains before harvest or to late‐maturity α‐amylase induction by temperature fluctuations during grain maturation. The most effective and visually intuitive approach for selecting varieties with high FN across variable environments was a combination of joint regression, such as Finlay–Wilkinson and Eberhart and Russell, with biplot methods such as the additive main effects and multiplicative interaction model (AMMI) and the genotype main effects and genotype × environment interaction model (GGE). We identify stable lines for FN resistance and provide a means to analyze unbalanced, multienvironment data from breeding and variety trials.
RNA chaperones: Potential candidates for engineering salt tolerance in rice
Authors: Ganie Showkat Ahmad 
Published: February 2020

AbstractRNA chaperone activity is crucial for proper folding and expression of messenger RNAs under abiotic stresses. There is functional conservation of plant and bacterial RNA chaperones, and they have been characterized mainly with respect to cold stress. The aim of this article was to compile all published rice (Oryza sativa L.) RNA chaperone genes, and to logically associate their RNA chaperone activity with salt tolerance. Based on the effects on transgenic plants under other abiotic stresses and the related published literature about the role of RNA chaperones in other plant species, I speculate that rice RNA chaperones are promising candidates for engineering salt tolerance in rice. Existing microarray data, showing that RNA chaperones of rice are highly responsive to salinity, are reviewed. Future functional studies will be required to characterize the range of functions of RNA chaperones in rice and other plants. Research avenues proposed in this review article provide a potential path to exciting research on rice salt tolerance.
Energy‐efficient void avoidance geographic routing protocol for underwater sensor networks
Authors: Alasarpanahi Hamed , Ayatollahitafti Vahid , Gandomi Abolfazl 
Published: February 2020

SummaryUnderwater wireless sensor networks (UWSNs) consist of a group of sensors that send the information to the sonobuoys at the surface level. Void area, however, is one of the challenges faced by UWSNs. When a sensor falls in a void area of communication, it causes problems such as high latency, power consumption, or packet loss. In this paper, an energy‐efficient void avoidance geographic routing protocol (EVAGR) has been proposed to handle the void area with low amount of energy consumption. In this protocol, a suitable set of forwarding nodes is selected using a weight function, and the data packets are forwarded to the nodes inside the set. The weight function includes the consumed energy and the depth of the candidate neighboring nodes, and candidate neighboring node selection is based on the packet advancement of the neighboring nodes toward the sonobuoys. Extensive simulation experiments were performed to evaluate the efficiency of the proposed protocol. Simulation results revealed that the proposed protocol can effectively achieve better performance in terms of energy consumption, packet drop, and routing overhead compared with the similar routing protocol.
Message trust‐based secure multipath routing protocol for opportunistic networks
Authors: Dhurandher Sanjay K. , Singh Jagdeep , Woungang Isaac , Kumar Raghav , Gupta Geetanshu 
Published: February 2020

SummaryOpportunistic networks (OppNets) are composed of wireless nodes opportunistically communicating with each other. These networks are designed to operate in a challenging environment characterized by high delay, intermittent connectivity, and no guarantee of fixed path between the sender and the destination nodes. One of the most vital issues in designing and maintaining practical networks over a time period is the security of the messages flowing in OppNets. This paper proposes a new method called message trust‐based secure multipath routing protocol (MT‐SMRP) for opportunistic networks. Various routing protocols such as ProPHet, Epidemic, and HiBOp, to name a few, have been proposed for OppNets, but none of these have applied a secure multipath routing technique. The proposed MT‐SMRP scheme relays the message to the destination through the disjoint paths, each applying a soft‐encryption technique to prevent message fabrication attacks. Simulations are conducted using the Haggle Infocom'06 real mobility data traces, showing that when time‐to‐live is varied, (1) the proposed MT‐SMRP scheme outperforms D‐MUST by 18.10%, 7.55%, 3.275%, respectively, in terms of delivery probability, messages dropped, and average latency; (2) it also outperforms SHBPR by 21.30%, 7.44%, and 4.85%, respectively, in terms of delivery probability, messages dropped, and average latency. Under similar performance metrics, the performance of MT‐SMRP is also shown to be better than that of D‐MUST and SHBPR when the buffer size (respondents. the message generation interval) is varied.
Impact of diabetes on clinical outcome of patients with heart failure undergoing ICD and CRT procedures: results from the German Device Registry
Authors: Kaya Elif , Senges Jochen , Hochadel Matthias , Eckardt Lars , Andresen Dietrich , Ince Hüseyin , Spitzer Stefan G. , Kleemann Thomas , Maier Sebastian S.K. , Jung Werner , Stellbrink Christoph , Rassaf Tienush , Wakili Reza 
Published: February 2020

AbstractAimsDiabetes mellitus (DM) has a negative impact on prognosis in patients with heart failure (HF). The role impact of DM in HF patients with implantable cardioverter defibrillator (ICD) or cardiac resynchronization therapy (CRT) devices might differ and remains unclear. The aim of our study was to investigate the impact of DM on periprocedural complications and clinical outcome in HF patients undergoing ICD or CRT implantation.Methods and resultsWithin the German Device Registry, data from 50 German centres were collected between January 2007 and February 2014. A retrospective analysis of n = 5329 patients undergoing ICD implantation was conducted. Patients' characteristics, procedural data, periprocedural complications, and post‐procedural clinical outcome, including a composite clinical endpoint of all‐cause mortality, stroke, and myocardial infarction (MACCE), were analysed. Subgroup analysis were performed for ICD and CRT implantations. Median follow‐up was 15.7 (12.9; 20.0) and 16.2 (12.8; 21.2) months in DM and non‐DM patients. Of 5329 patients enrolled, n = 1448 (27.2%) had a diagnosis of DM. Within the cohort, 94% of DM and 90% of non‐DM patients had a diagnosis of HF. Patients with DM were older, had higher body mass index, and higher rate of cardiovascular comorbidities compared with non‐DM patients. Unadjusted and adjusted analyses revealed similar all‐over intrahospital periprocedural complication rates in both groups (4.1% vs 3.9%). Unadjusted Kaplan–Meier survival analysis showed higher all‐cause mortality after 1 year (9.0% vs 6.3%; log‐rank P = 0.001) with higher MACCE rates (10.0% vs 7.3%; P < 0.001) in the DM group versus non‐DM patients. After multivariable adjustment for relevant covariates, the association of DM to MACCE disappeared [HR 1.11 (0.89‐1.38)]. Because chronic kidney disease (CKD) was clearly associated with increased 1 year MACCE after multivariate adjustment [odds ratio (OR) 2.11 (1.68–2.64)], a subgroup analysis was performed showing a strong trend towards more perioperative complications in DM patients with CKD [OR 2.16 (0.9–5.21)], while no effect of DM was observed in patients without CKD [OR 0.73 (0.42–1.28)].ConclusionsThe overall risk of periprocedural complications and short‐term (1 year) clinical outcome in patients with DM and HF undergoing ICD or CRT defibrillator (CRT‐D) implantation was not increased. In contrast, CKD was associated with an increased risk of 1 year MACCE in HF patients undergoing ICD/CRT‐D implantation.
Distinct variation in taste quality of Congou black tea during a single spring season
Authors: Yu Penghui , Huang Hao , Zhao Xi , Zhong Ni , Zheng Hongfa , Gong Yushun 
Published: February 2020

AbstractThe quality of Congou black tea fluctuates greatly with the changing seasons. However, variations in the taste quality of Congou black tea manufactured during a single spring season are far from clear. Here, we analyzed the taste quality of HuangJinCha (HJC) Congou black tea using sensory evaluation and found the taste quality of black tea manufactured in the early spring was better than that manufactured in the late spring. Principal component analysis (PCA) and cluster analysis for the data from the electronic tongue confirmed the variation and revealed that April 4 may be the critical time point at which variations in taste quality become apparent. The contents of tea polyphenols (TP), total catechins (TC), total flavones, (‐)‐epigallocatechin gallate (EGCG), (‐)‐epicatechin gallate (ECG), and gallic acid (GA) showed increasing trends, whereas total amino acids (TAA) declined over time. Moreover, the variations in total amino acids (r = 0.846) and total flavones (r = ‐ 0.858) were highly significantly correlated with the average taste quality score (p < .01), suggesting these compounds were the primary factors responsible for the fluctuation in taste quality of Congou black tea processed during a single spring season.
Optimal Tilt Angle Determination for PV Panels Using Real Time Data Acquisition
Authors: Sharma Manoj Kumar , Kumar Deepak , Dhundhara Sandeep , Gaur Dipesh , Verma Yajvender Pal 
Published: February 2020

AbstractSolar energy is one of the promising renewable energy sources which has the potential to meet the future energy demand around the world. To maximize the irradiance fall, solar panels are generally equipped with a motor tracking system and are placed at a specific tilt angle. However, tracking methods are not cost‐effective and a fixed tilt angle is not productive. This study proposes a method for harnessing maximum output from photovoltaic (PV) panels throughout the year by determining the optimal tilt angle. The investigation is performed on real‐time solar PV panels of 5 kWp rated capacity installed at 10°, 20°, 25°, 30°, and 40° angle on the rooftop of engineering institute situated at Chandigarh, India. The real‐time power generation response for a year is used to find the optimal tilt angle. The results obtained from the practical setup are validated by comparing it with the simulation results of the regression analysis. In addition, the impact of the optimal angle on total power generation and carbon emissions is analyzed. The results reveal that the proposed approach is quite effective to increase the power generation of PV panels up to 7–8% and can be practically implemented in any location throughout the world.
Transoral robotic surgery for recurrent cancers of the upper aerodigestive tract—Systematic review and meta‐analysis
Authors: Hardman John , Liu ZiWei , Brady Grainne , Roe Justin , Kerawala Cyrus , Riva Francesco , Clarke Peter , Kim Dae , Bhide Shreerang , Nutting Christopher , Harrington Kevin , Paleri Vinidh 
Published: February 2020

AbstractBackgroundTransoral robotic surgery (TORS) for recurrent head and neck (H&N) cancer is an emerging but relatively infrequent procedure.MethodsSystematic review and meta‐analysis of studies reporting survival data and functional outcomes for patients undergoing TORS for previously treated H&N cancers.ResultsEight hundred seventy‐eight records were identified, of which eight were eligible for inclusion, covering 161 cases (range 1‐64). The pooled rates were as follows: 2‐year overall survival 73.8% (4 studies, range 70.6‐75.0, 95% confidence intervals (CI) 65.4 to 81.5, [I2 0.0%, P = 1.0]); 2‐year disease‐free survival 74.8% (4 studies, range 56.2‐92.0, 95% CI 63.3 to 84.8, [I2 36.9%, P = .2]); postoperative hemorrhage 9.3% (4 studies, range 3.3‐13.3, 95% CI 4.7 to 15.1, [I2 0.0%, P = .5]).ConclusionsFunctional and oncological outcomes are favorable, although the follow‐up is limited in the literature. Larger cohorts with longer follow‐up are needed for definitive conclusions to be drawn.
Baseline and interim PET‐based outcome prediction in peripheral T‐cell lymphoma: A subgroup analysis of the PETAL trial
Authors: Schmitz Christine , Rekowski Jan , Müller Stefan P. , Hertenstein Bernd , Franzius Christiane , Ganser Arnold , Bengel Frank M. , Kroschinsky Frank , Kotzerke Jörg , La Rosée Paul , Freesmeyer Martin , Hoeffkes Heinz‐Gert , Hertel Andreas , Behringer Dirk , Mesters Rolf , Weckesser Matthias , Mahlmann Stefan , Haberkorn Uwe , Martens Uwe , Prange‐Krex Gabriele , Brenner Winfried , Giagounidis Aristoteles , Moeller Regina , Runde Volker , Sandmann Matthias , Hautzel Hubertus , Wilop Stefan , Krohn Thomas , Dürk Heinz , Heike Michael , Alashkar Ferras , Brinkmann Marcus , Trenn Guido , Wacker Dietmar , Kreisel‐Büstgens Christiane , Bernhard Helga , Heil Gerhard , Larisch Rolf , Kurch Lars , Jöckel Karl‐Heinz , Hoelzer Dieter , Klapper Wolfram , Boellaard Ronald , Dührsen Ulrich , Hüttmann Andreas 
Published: February 2020

AbstractThe prospective randomized Positron Emission Tomography (PET)‐Guided Therapy of Aggressive Non‐Hodgkin Lymphomas (PETAL) trial was designed to test the ability of interim PET (iPET) to direct therapy. As reported previously, outcome remained unaffected by iPET‐based treatment changes. In this subgroup analysis, we studied the prognostic value of baseline total metabolic tumor volume (TMTV) and iPET response in 76 patients with T‐cell lymphoma. TMTV was measured using the 41% maximum standardized uptake value (SUV41max) and SUV4 thresholding methods. Interim PET was performed after two treatment cycles and evaluated using the ΔSUVmax approach and the Deauville scale. Because of significant differences in outcome, patients with anaplastic lymphoma kinase (ALK)‐positive lymphoma were analyzed separately from patients with ALK‐negative lymphoma. In the latter, TMTV was statistically significantly correlated with progression‐free survival, with thresholds best dichotomizing the population, of 232 cm3 using SUV41max and 460 cm3 using SUV4. For iPET response, the respective thresholds were 46.9% SUVmax reduction and Deauville score 1‐4 vs 5. The proportion of poor prognosis patients was 46% and 29% for TMTV by SUV41max and SUV4, and 29% and 25% for iPET response by ΔSUVmax and Deauville, respectively. At diagnosis, the hazard ratio (95% confidence interval) for poor prognosis vs good prognosis patients according to TMTV was 2.291 (1.135‐4.624) for SUV41max and 3.206 (1.524‐6.743) for SUV4. At iPET, it was 3.910 (1.891‐8.087) for ΔSUVmax and 4.371 (2.079‐9.187) for Deauville. On multivariable analysis, only TMTV and iPET response independently predicted survival. Patients with high baseline TMTV and poor iPET response (22% of the population) invariably progressed or died within the first year (hazard ratio, 9.031 [3.651‐22.336]). Due to small numbers and events, PET did not predict survival in ALK‐positive lymphoma. Baseline TMTV and iPET response are promising tools to select patients with ALK‐negative T‐cell lymphoma for early allogeneic transplantation or innovative therapies.