bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Other Gates: Anglo-American Influences on and from Dublin
Authors: Purkis Charlotte 
Published: November 2020

AbstractAn important influence on the foundation of the Dublin Gate Theatre in 1928 was the London Gate Theatre Studio. This chapter offers a historiographical survey concerning how the range of connections between these theatres have been treated by theatre commentators up to the present. Alongside this re-examination is a discussion of two other theatres that were also inspired by the London Gate, but established independently by the two London co-directors, Peter Godfrey and Velona Pilcher. Godfrey revived the early programming from London in 1943 at his ‘transplanted’ theatre in Hollywood, which also connected Los Angeles emigré culture back to Ireland. In London, Pilcher worked with a group of women associates to found a ‘new Gate’, the Watergate Theatre Club in 1949, which, with its avant-garde artistic ethos, had a cultural impact on the post-war London scene similar to the achievements of the earlier Gate theatres.
Prussian Discipline and Lesbian Vulnerability: Christa Winsloe’s Children in Uniform at the Gate
Authors: Ivory Yvonne 
Published: November 2020

AbstractThis chapter examines the Dublin production and critical reception of Christa Winsloe’s Children in Uniform, which ran to full houses at the Gate for three weeks in April 1934. The play, which deals with the love between a Prussian schoolgirl and her female teacher, had premiered in Leipzig (1930), run successfully in Berlin (1931), and been adapted for the screen as Mädchen in Uniform (1931) before it was translated into English for a successful London run in 1932-1933. Edwards and mac Liammóir probably saw the original German play in Berlin in 1931. Using the prompt copy, lighting plots, photographs and reviews, the chapter shows how Edwards used expressionistic lighting and sonic leitmotifs to underscore the authoritarian regime within which the relationship between the women develops. In following the Berlin staging, Edwards produced a more subversive version of the play than that seen by London audiences or cinema goers.
Overview of MIGS
Authors: Wang Jing , Barton Keith 
Published: November 2020

Abstract
The term, minimally- or micro-invasive glaucoma surgery (MIGS), has entered common ophthalmic parlance and is playing an increasing role in the management of glaucoma patients. In common, the devices and procedures referred to are safer, less tissue invasive and associated with faster recovery than traditional filtering surgery, such as trabeculectomy or aqueous shunt implantation. MIGS can be categorized according to the tissue they target (or bypass): trabecular meshwork (TM) MIGS, subconjunctival MIGS, suprachoroidal MIGS and newer cycloablation procedures. A number of MIGS devices and techniques (e.g. TM MIGS) have relatively modest efficacy, but potential utility in a very large group of glaucoma patients with disease that is insufficiently severe to justify the invasiveness of conventional filtration surgery and the consequent intensity of postoperative care yet, burdened with medication and the attendant side effects and compliance issues thereof. On the other hand, subconjunctival MIGS devices, which are associated with bleb-related complications, can potentially achieve efficacy approaching that of traditional filtering surgery and are appropriate in selected individuals when larger IOP reductions are required, the exception being cases where glaucoma is very advanced. This book covers the techniques that are most commonly regarded as eligible to sit under the MIGS umbrella.
Irrespective of the modest efficacy of many MIGS devices and techniques, the favourable safety profile lowers the threshold for early glaucoma surgery, especially when combined with cataract surgery, potentially delaying the requirement for more invasive surgery and associated risks.
Globalization of MIGS
Authors: Sng Chelvin C. A. , Tham Clement C. , Budenz Donald L. , Healey Paul R. , Wang Ningli 
Published: November 2020

AbstractGlobalization is a comprehensive phenomenon with significant implications for global health. The globalization of minimally invasive glaucoma surgery (MIGS) is currently still a work in progress, with these devices slowly making inroads into Asia, Australasia, South America, and South Africa. Although MIGS companies can enjoy a quantum leap in economies of scale by serving global markets rather than only a confined domestic market, there are considerable economic, logistical, training, legal, and regulatory challenges that they need to overcome. The globalization of MIGS may benefit glaucoma patients worldwide, by reducing medication burden, improving the quality of life, and potentially decreasing the global incidence of glaucoma-related blindness.
iStent: Trabecular Micro-Bypass Stent
Authors: Larsen Christine L. , Samuelson Thomas W. 
Published: November 2020

AbstractWithin the class of procedures termed minimally invasive glaucoma surgery (MIGS), the iStent Trabecular Micro-Bypass Stent (Glaukos Corporation, San Clemente, CA, USA) is an intraocular implant that resides within Schlemm’s canal and allows for direct bypass of the trabecular meshwork by aqueous fluid. The acceptance of MIGS is growing due to its role in lowering intraocular pressure in mild-to-moderate glaucoma combined with its favorable safety profile. With transscleral glaucoma-filtering surgery, there is an increased potential for significant complications including hypotony, suprachoroidal hemorrhage, and long-term risk of endophthalmitis. By contrast, the iStent minimizes these risks and has demonstrated similarities to cataract surgery in terms of associated complications. Multiple publications have described both the safety and efficacy of the implant. These studies are reviewed in addition to a description of the implantation technique and postoperative management pearls. The second-generation model, the iStentinject, may ease implantation and the use of multiple stents may potentially play a role in more advanced disease.
Ab-Interno Trabeculotomy
Authors: Rabin Richard L. , Han Jaehong , Rhee Douglas J. 
Published: November 2020

Abstract
The Trabectome (NeoMedix Corporation, San Juan Capistrano, CA, USA) is a US Food and Drug Administration—approved surgical device which removes a segment of the trabecular meshwork and the inner wall of the Schlemm’s canal using an ab-interno approach, enhancing aqueous outflow via increased access to the Schlemm’s canal and the collector channels. This is a bleb-less procedure which spares the conjunctiva, hence does not adversely affect the outcome of subsequent conventional glaucoma filtration surgeries. Multiple studies have shown that Trabectome surgery results in a reduction in IOP and the number of ocular hypotensive agents, though the efficacy is modest compared with conventional filtration surgery. The safety profile of Trabectome surgery is favorable compared with conventional glaucoma surgery, with the most common complication being intraoperative and postoperative bleeding. Additional research is required to understand how the efficacy of Trabectome surgery can be maximized.
XEN Gel Implant
Authors: Au Leon , Stalmans Ingeborg 
Published: November 2020

AbstractAmong all the novel glaucoma surgical devices, the XEN Gel Implant (Allergan plc, Dublin, Ireland) is the only one which uses anab-internoapproach to drain aqueous to the subconjunctival space, similar to conventional filtration surgery. Most MIGS procedures target the Schlemm’s canal and the collector channels which can be difficult to locate. The patency of the downstream drainage system cannot be accurately assessed and the episcleral venous pressure cannot be routinely measured, leading to unpredictable surgical outcomes for trabecular bypass surgery. In contrast, subconjunctival aqueous drainage is more effective at lowering the intraocular pressure, as is evidenced by the efficacy of trabeculectomy which has a long track record. The main advantages of the XEN Gel Implant over other filtering procedures include its less invasive surgical procedure and the favorable safety profile, fast visual recovery, and short surgery duration, rendering this implant particularly suited for patients who are unable to tolerate a long surgical duration or a delayed visual recovery. Although designed as a stand-alone procedure, XEN implantation can be combined with phacoemulsification in patients with concurrent cataract. Although its pressure-lowering ability appears to be superior to trabecular bypass and suprachoroidal MIGS devices, there are surgical nuances which can be difficult to master and the pre- and postoperative management is critical in the success of the XEN Glaucoma Treatment System.
PRESERFLO MicroShunt
Authors: Kerr Nathan M. , Ahmed Iqbal Ike K. , Pinchuk Leonard , Sadruddin Omar , Palmberg Paul F. 
Published: November 2020

Abstract
The PRESERFLO® MicroShunt (Santen Pharmaceutical Co. Ltd., Osaka, Japan), formerly called the InnFocus MicroShunt®, is a trans-scleral device that shunts aqueous humour from the anterior chamber to a filtering bleb under the conjunctiva and Tenon’s capsule. Manufactured from an inert biocompatible material called poly(styrene-block-isobutylene-block-styrene), or ‘SIBS’, the device elicits minimal foreign body reaction and inflammation; potentially reducing the risk of bleb-related fibrosis and failure. The MicroShunt is 8.5 mm long with a 70 μm lumen and is designed to minimize hypotony based on the Hagen–Poiseuille equation. Inserted via an ab-externo approach, the MicroShunt eliminates the need for creation of a scleral flap, sclerostomy, iridectomy, scleral flap suturing and postoperative suture lysis. Clinical trials show promising results with the MicroShunt achieving intraocular pressure reduction approaching that of trabeculectomy, the current gold standard for treating refractory glaucoma.
Suprachoroidal MIGS Devices
Authors: Garcia-Feijoo Julian , Martinez-de-la-Casa Jose Maria , Perucho Lucia 
Published: November 2020

AbstractThe suprachoroidal outflow pathway has the potential to reduce intraocular pressure (IOP) significantly but has been associated with sight-threatening complications including severe and prolonged hypotony. Historically, suprachoroidal devices have been implantedab externo requiring a conjunctival peritomy and scleral flap dissection. Additionally, the long-term efficacy of previous attempts to harness this space has been disappointing due to occlusion of implanted devices by fibrosis in the suprachoroidal space. More recently, there have been a number of suprachoroidal devices that are injectedab interno., including the CyPass Micro-Stent (Alcon Laboratories Inc., Fortworth, Texas, USA), the iStent Supra (Glaukos Corporation, San Clemente, CA, USA) and the MINIject (iSTAR Medical Isnes, Belgium). These have utilized a clear corneal entry, thereby sparing the conjunctiva. Early results with theseab-internodevices showed safety and efficacy in IOP-lowering that is similar to Schlemm’s canal minimally invasive glaucoma surgery devices and procedures. Despite theab-internoapproach, their long-term efficacy also seems to be limited by fibrosis. In addition, the first commercially availableab-internosuprachoroidal device, the CyPass Micro-Stent, has been voluntarily withdrawn globally by the manufacturer in August 2018, after 5-year follow-up data demonstrated a higher level of endothelial cell loss with the device than in controls. The iStent Supra and MINIject are not yet available commercially.
New Modalities of Cycloablation and High-Intensity-Focused Ultrasound
Authors: Kolomeyer Natasha Nayak , Moster Marlene R. 
Published: November 2020

AbstractCycloablative or cyclodestructive procedures aim to lower intraocular pressure (IOP) by decreasing the function of the ciliary body and thereby decreasing the rate of aqueous production. Cycloablative procedures were typically used in refractory glaucoma in eyes with poor visual potential; however, more focused energy and targeted destruction of the ciliary body have led to an increase in cyclodestructive treatment options that are now an important adjunct to our surgical armamentarium. This chapter highlights the history of these procedures while focusing on current modalities including transscleral diode cyclophotocoagulation (TSCPC), micropulse transscleral diode cyclophotocoagulation (MP-TSCPC, MicroPulse P3, IRIDEX IQ810 Laser System, Mountain View, CA, USA), and High-Intensity Focused Ultrasound (HIFU). Specifically, this chapter discusses the protocols, indications, results, and complications of each featured procedure.
Dynamic mode decomposition analysis of rotating detonation waves
Authors: Bohon M. D. , Orchini A. , Bluemner R. , Paschereit C. O. , Gutmark E. J. 
Published: November 2020

AbstractA rotating detonation combustor (RDC) is a novel approach to achieving pressure gain combustion. Due to the steady propagation of the detonation wave around the perimeter of the annular combustion chamber, the RDC dynamic behavior is well suited to analysis with reduced-order techniques. For flow fields with such coherent aspects, the dynamic mode decomposition (DMD) has been shown to capture well the dominant oscillatory features corresponding to stable limit-cycle or quasi-periodic behavior within its dynamic modes. Details regarding the application of the technique to RDC—such as the number of frames, the effect of subtracting the temporal mean from the processed dataset, the resulting dynamic mode shapes, and the reconstruction of the dynamics from a reduced set of dynamic modes—are analyzed and interpreted in this study. The DMD analysis is applied to two commonly observed operating conditions of rotating detonation combustion, viz., (1) a single spinning wave with weak counter-rotating waves and (2) a clapping operating mode with two counter-propagating waves at equal speed and strength. We show that care must be taken when applying DMD to RDC datasets due to the presence of standing waves (expressed as either counter-propagating azimuthal waves or longitudinal pulsations). Without accounting for these effects, the reduced-order reconstruction fails using the standard DMD approach. However, successful application of the DMD allows for the reconstruction and separation of specific wave modes, from which models of the stabilization and propagation of the primary and counter-rotating waves can be derived.
Review of Rare Earth Elements as Fertilizers and Feed Additives: A Knowledge Gap Analysis
Authors: Tommasi Franca , Thomas Philippe J. , Pagano Giovanni , Perono Genevieve A. , Oral Rahime , Lyons Daniel M. , Toscanesi Maria , Trifuoggi Marco 
Published: November 2020

AbstractRare earth elements (REEs) are key constituents of modern technology and play important roles in various chemical and industrial applications. They also are increasingly used in agricultural and zootechnical applications, such as fertilizers and feed additives. Early applications of REEs in agriculture have originated in China over the past several decades with the objective of increasing crop productivity and improving livestock yield (e.g., egg production or piglet growth). Outside China, REE agricultural or zootechnical uses are not currently practiced. A number of peer-reviewed manuscripts have evaluated the adverse and the positive effects of some light REEs (lanthanum and cerium salts) or REE mixtures both in plant growth and in livestock yield. This information was never systematically evaluated from the growing body of scientific literature. The present review was designed to evaluate the available evidence for adverse and/or positive effects of REE exposures in plant and animal biota and the cellular/molecular evidence for the REE-associated effects. The overall information points to shifts from toxic to favorable effects in plant systems at lower REE concentrations (possibly suggesting hormesis). The available evidence for REE use as feed additives may suggest positive outcomes at certain doses but requires further investigations before extending this use for zootechnical purposes.
Femoral neck shaft angle in relation to the location of femoral stress fracture in young military recruits: femoral head versus femoral neck stress fracture
Authors: Kim Dong-Kyu , Kim Tae Ho 
Published: November 2020

Abstract
Objective
To evaluate the influences of the femoral neck shaft angle (FNSA) on the location of the femoral stress fracture and to assess the potential differences in FNSA between fractured and normal femurs.

Materials and methods
Thirty-seven patients with femoral stress fractures who underwent both plain hip radiographs and MRI, from January 2016 to September 2019, were retrospectively included. Patients were classified as having either femoral head stress fracture (group A, n = 26) or femoral neck stress fracture (group B, n = 11). The FNSA was measured in anteroposterior (AP) hip radiograph. The Mann-Whitney U testing was used to compare the continuous values between the two groups. A receiver operating characteristic (ROC) analysis was used to evaluate the value of FNSA for predicting the risk of femoral stress fracture.

Results
The FNSA was significantly higher in group A (median 135.9°, range 129.5–138.6°) than group B (median 124.3°, range 119.5–129.0°) (p < 0.001), but there were no significant differences in other clinical factors. Furthermore, the FNSA was significantly higher at the fractured femurs (median 135.9°, range 129.9–138.6°) than contralateral normal femurs (median 127.9°, range 123.8–132.1°) in the patients with unilateral femoral head stress fracture (n = 22) (p < 0.001). The ROC analysis revealed that the area under curve (AUC), sensitivity, and specificity for predicting the risk of femoral head stress fracture were 0.807, 72.7%, and 68.2%, respectively, at a FNSA cutoff of 131.0°.

Conclusion
FNSA was associated with the location of the femoral stress fracture. In addition, FNSA could serve as a predictive factor for the risk of femoral head stress fractures.
IL-15 superagonist N-803 improves IFNγ production and killing of leukemia and ovarian cancer cells by CD34+ progenitor-derived NK cells
Authors: Van der Meer J. M. R. , Maas R. J. A. , Guldevall K. , Klarenaar K. , de Jonge P. K. J. D. , Evert J. S. Hoogstad-van , van der Waart A. B. , Cany J. , Safrit J. T. , Lee J. H. , Wagena E. , Friedl P. , Önfelt B. , Massuger L. F. , Schaap N. P. M. , Jansen J. H. , Hobo W. , Dolstra H. 
Published: November 2020

AbstractAllogeneic natural killer (NK) cell transfer is a potential immunotherapy to eliminate and control cancer. A promising source are CD34 + hematopoietic progenitor cells (HPCs), since large numbers of cytotoxic NK cells can be generated. Effective boosting of NK cell function can be achieved by interleukin (IL)-15. However, its in vivo half-life is short and potent trans-presentation by IL-15 receptor α (IL-15Rα) is absent. Therefore, ImmunityBio developed IL-15 superagonist N-803, which combines IL-15 with an activating mutation, an IL-15Rα sushi domain for trans-presentation, and IgG1-Fc for increased half-life. Here, we investigated whether and how N-803 improves HPC-NK cell functionality in leukemia and ovarian cancer (OC) models in vitro and in vivo in OC-bearing immunodeficient mice. We used flow cytometry-based assays, enzyme-linked immunosorbent assay, microscopy-based serial killing assays, and bioluminescence imaging, for in vitro and in vivo experiments. N-803 increased HPC-NK cell proliferation and interferon (IFN)γ production. On leukemia cells, co-culture with HPC-NK cells and N-803 increased ICAM-1 expression. Furthermore, N-803 improved HPC-NK cell-mediated (serial) leukemia killing. Treating OC spheroids with HPC-NK cells and N-803 increased IFNγ-induced CXCL10 secretion, and target killing after prolonged exposure. In immunodeficient mice bearing human OC, N-803 supported HPC-NK cell persistence in combination with total human immunoglobulins to prevent Fc-mediated HPC-NK cell depletion. Moreover, this combination treatment decreased tumor growth. In conclusion, N-803 is a promising IL-15-based compound that boosts HPC-NK cell expansion and functionality in vitro and in vivo. Adding N-803 to HPC-NK cell therapy could improve cancer immunotherapy.
Colorectal Cancer Screening in Ghana: Physicians’ Practices and Perceived Barriers
Authors: Lussiez Alisha , Dualeh Shukri H. A. , Dally Charles K. , Opoku Baafuor K. , Raghavendran Krishnan , Aitpillah Francis , Boateng Edward , Darkwah Dominic , Gyasi‐Sarpong Kofi Christian , Kolars Joseph C. , Kwakye Gifty 
Published: November 2020

AbstractIntroductionGhana has seen a rise in the incidence of colorectal cancer (CRC) over the past decade. In 2011, the Ghana National Cancer Steering Committee created a guideline recommending fecal occult blood testing (FOBT) for CRC screening in individuals over the age of 50. There is limited data available on current Ghanaian CRC screening trends and adherence to the established guidelines.MethodsWe conducted a survey of 39 physicians working at the Komfo Anokye Teaching Hospital in Kumasi, Ghana. The survey evaluates physician knowledge, practice patterns, and perceived personal‐, patient‐ and system‐level barriers pertaining to CRC screening.ResultsAlmost 10% of physicians would not recommend colorectal cancer screening for asymptomatic, average risk patients who met the age inclusion criteria set forth in the national guidelines. Only 1 physician would recommend FOBT as an initial screening test for CRC. The top reasons for not recommending CRC screening with FOBT were the lack of equipment/facilities for the test (28.1%) and lack of training (18.8%). The two most commonly identified barriers to screening identified by >85% of physicians, were lack of awareness of screening/not perceiving colorectal cancer as a serious health threat (patient‐level) and high screening costs/lack of insurance coverage (system‐level).ConclusionDespite creation of national guidelines for CRC screening, there has been low uptake and implementation. This is due to several barriers at the physician‐, patient‐ and system‐levels including lack of resources and physician training to follow‐up on positive screening results, limited monetary support and substantial gaps in knowledge at the patient level.