bluuebunny/crossref_metadata_2025_split huggingface dataset:
With whom do consumers interact?
Authors: Duong Hue Trong , Nguyen Long Thang Van , Vu Hong Tien 
Published: October 2019

Purpose
The purpose of this study is to investigate the effects of congruent and incongruent anonymous comments posted to an online health news article on personal risk perception. This association is examined through testing the moderating roles of perceived similarity and approval ratings, and the mediating roles of source credibility and content credibility.

Design/methodology/approach
Hypotheses regarding the impact of comments on personal risk perception were tested experimentally using a news article, comments and approval ratings about the ear picking behavior. Data were collected from 391 young Vietnamese respondents.

Findings
The influence of online comments (congruent vs incongruent) on personal risk perception was mediated by source credibility and content credibility. Further, data showed a direct effect of online comments on personal risk perception. Interestingly, the direct and indirect effects of online comments on personal risk perception were observed among participants who perceived that anonymous commenters were similar to them. Approval ratings had neither a main nor interaction effect with comments on the dependent variables.

Practical implications
The results indicate that marketers should consider online comments as a powerful form of social influence, which may alter consumers’ personal risk perception.

Originality/value
The present study adds to social marketing literature by showing how consumers’ online comments influence personal risk perception in the context of changing media ecosystem.
Reacting to negative online customer reviews
Authors: Piehler Rico , Schade Michael , Hanisch Ines , Burmann Christoph 
Published: October 2019

PurposeThe purpose of this paper is to investigate the effects of explanation and compensation, as specific accommodative management responses to negative online customer reviews, on potential customers.Design/methodology/approachThe scenario-based online experiment with 306 participants investigates the effects of explanation and compensation on potential customers’ purchase intentions in the hotel segment of the hospitality industry.FindingsThe results reveal that combining an explanation with compensation is the most effective management response; providing neither an explanation nor compensation is the least effective. The effects of management responses that entail providing only an explanation or compensation do not differ significantly.Research limitations/implicationsContinued research should investigate the effects of specific accommodative management responses in other service industries and other cultural settings and consider different kinds of explanations and compensation.Practical implicationsHotel managers in the hospitality industry should reply to negative online customer reviews by combining an explanation with compensation. Service providers that currently lack structures and procedures to identify service failures and their causes or that cannot take corrective actions should provide compensation. Service providers that currently have limited financial resources should provide explanations.Originality/valueThis study analyses the effects of explanation and compensation on potential customers’ purchase intentions. In addressing the effects on potential customers, instead of on complainants, the conceptual framework represents a novel combination of management responses from service recovery research with signalling theory, the search-experience-credence framework and risk reduction methods.
It looks nice, but does it work? Using student learning outcomes to assess library instructional spaces
Authors: Jarocki Zoe 
Published: October 2019

Purpose
The purpose of this paper is to discuss how a mixed-methods approach to assessing student learning was used to determine the efficacy of redesigned library instructional spaces.

Design/methodology/approach
In 2017, the library at San Diego State remodeled a classroom to support active learning. The author undertook a pilot study to compare outcomes from the active learning classroom (ALC) and the traditional computer lab (CL) classroom. The assessment was done after one-shot library sessions for four sections of the same course in the ALC and the CL. Students completed surveys to assess their reactions to the instruction and e-mailed the librarian copies of the articles that they selected which were analyzed for quality using a rubric.

Findings
The mean scores from the CL classroom sections were slightly higher for the survey questions, though it was not statistically significant. The articles selected by students in the ALC had a slightly higher average quality score on the rubric, however, it was not large enough to be statistically significant.

Research limitations/implications
This was a limited assessment project and the results may not be generalizable to other institutions or types of instruction. Overall, students selected high-quality resources and felt positive about the library after instruction in both library classrooms. The data did not demonstrate significant improvements in student learning outcomes or attitudes in the remodeled ALC.

Originality/value
This mixed-methods assessment technique can be used to evaluate student learning and attitudes about the library and may be adapted by other librarians. It may also be of interest to those interested in designing learning spaces in libraries.
Conditions for kin selection to bring cooperation and improve population growth: A response to Iritani
Authors: Kobayashi Kazuya 
Published: October 2019

Abstract

To clarify how intraspecific competition over fertilization affects population growth rates and community dynamics in plants, Kobayashi (Journal of Ecology, 2019) proposed analytical and simulation models based on the game theory. Within this framework, it is suggested that the negative density‐dependent effect arising from sexual selection is an important force for sustaining biodiversity. Relaxing certain assumptions made in the analytical model, Iritani (Journal of Ecology, 2019) successfully incorporated the effect of kin selection in the model. This change makes a significant contribution towards improving the generality of the model.

Here, I clarify the contribution of Iritani (Journal of Ecology, 2019) and explain the condition under which kin selection promotes the evolution of cooperation (facilitativeness).

Kin selection has the potential to promote the evolution of cooperation under certain conditions. However, it is difficult to maintain cooperative traits in high‐density environments where individuals must interact with many other conspecifics. Thus, even after the model was extended by Iritani, it cannot be used to state that the negative density‐dependent effect arising from intraspecific competition over fertilization does not exist, but it has successfully revealed that the situation is more complex in nature.

Synthesis. Kin selection exists wherever intraspecific interactions between individuals occur, but does not necessarily lead to the evolution of cooperation. More detailed theoretical and empirical studies are needed to determine whether sexual selection generally produces negative density dependence, even when kin selection is taken into account.
High Opportunity Cost Demand as an Indicator of Weekday Drinking and Distinctly Severe Alcohol Problems: A Behavioral Economic Analysis
Authors: Joyner Keanan J. , Meshesha Lidia Z. , Dennhardt Ashley A. , Borsari Brian , Martens Matthew P. , Murphy James G. 
Published: October 2019

IntroductionBehavioral economic theory views addiction as a reinforcer pathology characterized by excessive demand for drugs relative to alternatives. Complementary to this theory, Lamb and Ginsburg (Pharmacology Biochemistry and Behavior, 164, 2018, 62) describe addiction as a behavioral allocation disorder and predict that decisions to drink under increasingly stringent constraints are a central indicator of addiction. This study used a modified demand‐curve paradigm to examine alcohol demand in the context of a next‐day contingency (high opportunity cost demand) as a specific indicator of a severe pattern of alcohol problems.MethodsParticipants were 370 undergraduates (61.1% female, 86.5% white, Mage = 18.8) reporting multiple past‐month heavy drinking episodes (5/4 drinks per occasion for men/women) who completed 2 versions of an alcohol purchase task (APT), along with measures of past‐month alcohol use and problems. In 1 APT (low opportunity cost), students imagined they had no next‐day responsibilities, and in the other APT (high opportunity cost), they imagined having a 10:00 am test the next day. Item‐response theory analyses were used to determine mild and severe alcohol problems from the Young Adult Alcohol Consequences Questionnaire (Journal of Studies on Alcohol, 67, 2006, 169), and the most and least severe binge drinking days throughout the week.ResultsLow opportunity cost demand (β = 0.15, p = 0.02) significantly predicted beyond high opportunity cost demand for the least severe problems, and high opportunity cost demand (β = 0.17, p = 0.009) significantly predicted beyond low opportunity cost demand for the most severe problems. Similarly, low opportunity cost demand (β = 0.26, p < 0.001) was more highly associated with weekend drinking, whereas high opportunity cost demand (β = 0.21, p = 0.001) was more highly associated with weekday drinking.ConclusionsThe current results suggest high opportunity cost alcohol demand is a distinct marker of severe alcohol problems among college student heavy drinkers.
Efficacy and safety of tofacitinib dose de‐escalation and dose escalation for patients with ulcerative colitis: results from OCTAVE Open
Authors: Sands Bruce E. , Armuzzi Alessandro , Marshall John K. , Lindsay James O. , Sandborn William J. , Danese Silvio , Panés Julián , Bressler Brian , Colombel Jean‐Frédéric , Lawendy Nervin , Maller Eric , Zhang Haiying , Chan Gary , Salese Leonardo , Tsilkos Konstantinos , Marren Amy , Su Chinyu 
Published: October 2019

SUMMARYBackgroundFor patients with UC, flexible maintenance dosing therapy may confer advantages for safety, efficacy, costs and patient preference. Tofacitinib is an oral, small molecule JAK inhibitor for the treatment of UC.AimTo assess the efficacy and safety of tofacitinib dose de‐escalation and escalation in patients with UC.MethodsWe evaluated data (November 2017 data cut‐off) from OCTAVE Open, an ongoing, open‐label, long‐term extension study. The dose de‐escalation group comprised 66 tofacitinib induction responders in remission following 52 weeks' tofacitinib 10 mg b.d. maintenance therapy, subsequently de‐escalated to 5 mg b.d. in OCTAVE Open. The dose escalation group comprised 57 tofacitinib induction responders who experienced treatment failure while receiving 5 mg b.d. maintenance therapy, subsequently escalated to 10 mg b.d. in OCTAVE Open.ResultsAfter tofacitinib de‐escalation, 92.4% (61/66) and 84.1% (53/63) of patients maintained clinical response and 80.3% (53/66) and 74.6% (47/63) maintained remission, at months 2 and 12, respectively. After dose escalation, 57.9% (33/57) and 64.9% (37/57) of patients recaptured clinical response and 35.1% (20/57) and 49.1% (28/57) were in remission, at months 2 and 12, respectively. The incidence rate of herpes zoster with dose escalation (7.6 patients with events/100 patient‐years) was numerically higher than in the overall tofacitinib UC programme.ConclusionsFollowing tofacitinib de‐escalation in patients already in remission on 10 mg b.d., most maintained remission, although 25.4% lost remission, at month 12. For induction responders who dose‐escalated following treatment failure on 5 mg b.d. maintenance therapy, 49.1% achieved remission by month 12. (ClinicalTrials.gov number: NCT01470612).
Survey of cases of tick‐paralysis and the presence of the eastern paralysis tick, Ixodes holocyclus, and the southern paralysis tick, Ixodes cornuatus, in the Greater Melbourne Area
Authors: Barker D , Barker SC 
Published: October 2019

ObjectiveThe objective of this study was to test the hypothesis that the paralysis ticks, Ixodes holocyclus and Ixodes cornuatus, are epizootic and/or enzootic in the Greater Melbourne Area (GMA).MethodsWe examined the ticks in the museum collections of Australia, wrote to, phoned and visited veterinarians and other colleagues in the GMA to gather information about the cases of tick paralysis and to request the ticks for identification.ResultsWe present evidence of I. holocyclus at 24 postcodes and I. cornuatus at 28 postcodes in the GMA.ConclusionsWe found evidence that I. holocyclus is epizootic at four postcodes in the GMA: at East Melbourne, Williamstown, Moonee Ponds and Hoppers Crossing. We did not find evidence that I. holocyclus is enzootic in the GMA. I. cornuatus is apparently enzootic in the GMA at Bullengarook, Kinglake, Chum Creek and Healesville. Our hypothesis is that I. cornuatus is also enzootic at Mt Macedon, Gisborne and at other bushy postcodes in the GMA. Since this tick is apparently enzootic in the GMA, it may also be epizootic at postcodes adjacent to busy postcodes such as Bullengarook, Kinglake, Chum Creek and Healesville. The concept of hitch‐hiker larvae, nymphs and adult female ticks may explain many of the cases of tick paralysis due to I. holocyclus in the GMA. The accurate assessment of the risk of tick paralysis in dogs and cats in the GMA requires a more detailed map of the distribution of I. holocyclus and I. cornuatus in Victoria.
Secretory IgA accumulated in the airspaces of idiopathic pulmonary fibrosis and promoted VEGF, TGF-β and IL-8 production by A549 cells
Authors: Kobayashi K , Suzukawa M , Watanabe K , Arakawa S , Igarashi S , Asari I , Hebisawa A , Matsui H , Nagai H , Nagase T , Ohta K 
Published: October 2019

SummarySecretory IgA (SIgA) is a well-known mucosal-surface molecule in first-line defense against extrinsic pathogens and antigens. Its immunomodulatory and pathological roles have also been emphasized, but it is unclear whether it plays a pathological role in lung diseases. In the present study, we aimed to determine the distribution of IgA in idiopathic pulmonary fibrosis (IPF) lungs and whether IgA affects the functions of airway epithelial cells. We performed immunohistochemical analysis of lung sections from patients with IPF and found that mucus accumulated in the airspaces adjacent to the hyperplastic epithelia contained abundant SIgA. This was not true in the lungs of non-IPF subjects. An in-vitro assay revealed that SIgA bound to the surface of A549 cells and significantly promoted production of vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β and interleukin (IL)-8, important cytokines in the pathogenesis of IPF. Among the known receptors for IgA, A549 cells expressed high levels of transferrin receptor (TfR)/CD71. Transfection experiments with siRNA targeted against TfR/CD71 followed by stimulation with SIgA suggested that TfR/CD71 may be at least partially involved in the SIgA-induced cytokine production by A549 cells. These phenomena were specific for SIgA, distinct from IgG. SIgA may modulate the progression of IPF by enhancing synthesis of VEGF, TGF-β and IL-8.
Lymph node ratio as a prognostic marker in advanced laryngeal and hypopharyngeal carcinoma after primary total laryngopharyngectomy
Authors: Grasl Stefan , Janik Stefan , Parzefall Thomas , Formanek Michael , Grasl Matthaeus C. , Heiduschka Gregor , Erovic Boban M. 
Published: October 2019

AbstractBackgroundWe evaluated the prognostic value of lymph node ratio (LNR) in patients with advanced laryngeal and hypopharyngeal squamous cell carcinoma.Study DesignRetrospective chart review.MethodsBetween 1994 and 2018, 79 patients underwent total laryngopharyngectomy and adjuvant therapy. LNR was determined and statistically compared to patients’ overall survival (OS), disease‐specific survival (DSS), disease‐free survival (DFS), locoregional and distant failure.ResultsThe 5‐year OS, DSS and DFS rates were 45.6%, 73.4% and 56.9%, respectively. 24.1% and 25.3% developed loco‐ regional failure or distant metastatic disease, respectively. Univariate analyses showed that high LNR (cut‐off >0.07) was significantly associated with distant and locoregional failure. On multivariate analysis, LNR remained an independent predictor for OS (P = .004), DSS (P = .009) and DFS (P = .044).ConclusionIncreased LNR in patients with advanced laryngeal or hypopharyngeal carcinoma is significantly linked to shortened OS, DSS, DFS and higher locoregional and distant metastatic disease.
The influence of vestibular stimulation on metabolism and body composition
Authors: McKeown J. , McGeoch P. D. , Grieve D. J. 
Published: October 2019

AbstractObesity, diabetes and metabolic disease represent an ongoing and rapidly worsening public health issue in both the developed, and much of the developing world. Although there are many factors that influence fat storage, it has been clearly demonstrated that the homeostatic cornerstone of metabolism lies within the hypothalamus. Moreover, neuronal damage to vital areas of the hypothalamus can drive reregulation or dysregulation of endocrine function, energy expenditure and appetite, thereby promoting a shift in overall metabolic function towards a state of obesity. Therefore, identification of treatments that influence the hypothalamus to improve obesity and associated metabolic diseases has long been a medical goal. Interestingly, evidence from animal studies suggests that activating the vestibular system, specifically the macular gravity receptor, influences the hypothalamus in a way that decreases body fat storage and causes a metabolic shift towards a leaner state. Given that the macular element of the vestibular system has been shown to activate with transdermal electrical stimulation applied to the mastoids, this may be a potential therapeutic approach for obesity, diabetes or related metabolic diseases, whereby repetitive stimulation of the vestibular system influences hypothalamic control of metabolic homeostasis, thereby encouraging decreased fat storage. Here, we present an up‐to‐date review of the current literature surrounding the vestibular influence of the hypothalamus and associated homeostatic sites in the context of current and novel therapeutic approaches for improved clinical management of obesity and diabetes.
Explosions of Stupidity: Notes for an Urbanist Pedagogy
Authors: Ford Derek R. 
Published: October 2019

AbstractIn this article, Derek R. Ford develops an urbanist pedagogy, a particular mode of educational praxis that arises out of — and, more importantly, is oriented toward — the creation of the urban, a praxis that is internal to and constitutive of urban revolt. Ford does so with the help of two thinkers who are seldom theorized together: Henri Lefebvre and Jean‐François Lyotard. Taken together, Lefebvre and Lyotard allow him to advance a conception of the urban not as an object, thing, or distinct space (like the city), but as an incommunicable process that entails two distinct and interrelated creative educational elements: explosive confrontation and stupor. At the end of the article, Ford reads this urbanist pedagogy through a set of protest movements in West Germany.
The Art of Straying: Benjamin on Distraction and the Informal Education of the City
Authors: Lewis Tyson E. 
Published: October 2019

AbstractIn this article, Tyson E. Lewis argues for an alternative form of educational attunement beyond attentiveness. Discourses and practices of schooling emphasize being attentive as a primary educational virtue. This emphasis casts distraction as either the negation of attention or its deterioration. In either case, distraction lacks educational use and, as such, must be overcome through the cultivation of attention. Yet this approach to the question of attention versus distraction misses how distraction contains within itself a different kind of educational potentiality, a different kind of educational attunement. In an attempt to carve out space and time for distraction, Lewis turns to the writings of Walter Benjamin who offers up a more complex view of distraction than is presently found in educational philosophy. In particular, Benjamin argues that cities are not only places of negative forms of distraction (as mere diversions), but also places for cultivating productive distraction in the form of an open and alert attunement to new ways of experiencing and perceiving the relationship between world and self. Cities, for Benjamin, become educational spaces that teach lessons in a distracted form of life, the culmination of which is the creativity expressed in what he refers to as “the art of straying.”
Structural conformation and self‐assembly process of p31‐43 gliadin peptide in aqueous solution. Implications for celiac disease
Authors: Herrera María Georgina , Gómez Castro María Florencia , Prieto Eduardo , Barrera Exequiel , Dodero Veronica Isabel , Pantano Sergio , Chirdo Fernando 
Published: October 2019

Celiac disease (CeD) is a highly prevalent chronic immune‐mediated enteropathy developed in genetically predisposed individuals after ingestion of a group of wheat proteins (called gliadins and glutenins). The 13mer α‐gliadin peptide, p31‐43, induces proinflammatory responses, observed by in vitro assays and animal models, that may contribute to innate immune mechanisms of CeD pathogenesis. Since a cellular receptor for p31‐43 has not been identified, this raises the question of whether this peptide could mediate different biological effects. In this work, we aimed to characterize the p31‐43 secondary structure by different biophysical and in silico techniques. By dynamic light scattering and using an oligomer/fibril‐sensitive fluorescent probe, we showed the presence of oligomers of this peptide in solution. Furthermore, atomic force microscopy analysis showed p31‐43 oligomers with different height distribution. Also, peptide concentration had a very strong influence on peptide self‐organization process. Oligomers gradually increased their size at lower concentration. Whereas, at higher ones, oligomers increased their complexity, forming branched structures. By CD, we observed that p31‐43 self‐organized in a polyproline II conformation in equilibrium with β‐sheets‐like structures, whose pH remained stable in the range of 3–8. In addition, these findings were supported by molecular dynamics simulation. The formation of p31‐43 nanostructures with increased β‐sheet structure may help to explain the molecular etiopathogenesis in the induction of proinflammatory effects and subsequent damage at the intestinal mucosa in CeD.