bluuebunny/crossref_metadata_2025_split huggingface dataset:
High acoustic numerical aperture photoacoustic microscopy with improved sensitivity
Authors: Li Mingsheng , Chen Jiangbo , Wang Lidai 
Published: December 2019

Limited by the numerical aperture of ultrasonic detection, optical resolution photoacoustic microscopy (OR-PAM) has not achieved optimal sensitivity. To address this problem, we have developed a high acoustic numerical aperture (

∼

0.74

) OR-PAM (HNA-OR-PAM). Via engineering the acoustic lens, we implement the highest acoustic numerical aperture that a spherical concave lens can achieve. The sensitivity of HNA-OR-PAM is improved to around 160%—the state-of-the-art OR-PAM. Without averaging, the new system can image oxygen saturation in vivo with only 10-nJ pulse energy. The improved sensitivity allows us to image weaker absorbers, penetrate deeper, and reduce nonlinear effects induced by high pulse energy. Moreover, the photoacoustic view angle is augmented to 51.8 deg and makes tilted features more visible. We validate the improved view angle in both a phantom study and brain imaging.
Dynamics of optical polarizability of liquid water exposed to intense laser light
Authors: Kononenko Vitali V. , Gololobov Viktor M. , Konov Vitaly I. 
Published: December 2019

Variations in the optical properties of pure water induced by a femtosecond laser (wavelength 800 nm, intensity

∼

10

12

W

/

c
m

2

) were studied by a pump–probe interferometric technique. Laser photoionization was shown to increase both the refractive index and absorbance of the water. While the absorption dynamics were found to be in a good agreement with previous studies, the temporal behavior of the refractive index exhibited novel features. It was found that the always-positive refractive index contains distinct peaks at the beginning and end of the laser pulses. This behavior was attributed to the Kerr effect in water molecules and in wet/hydrated electrons produced by photoionization, respectively.
Perceived Freedom in Leisure Scale-25: Testing the construct validity for university students
Authors: Yerlisu Lapa Tennur , Tercan Kaas Evren 
Published: December 2019

Leisure behaviour is an important study area of the literature recently. In apprehending leisure behaviour, perceived freedom in leisure is a significant dimension. The aim of the study is to test validity of “Perceived Freedom in Leisure Scale (PFLS)” by confirmatory factor analysis (CFA). Study group of this descriptive research consists of 228 university students. Reliability was calculated by internal consistency coefficient Cronbach’s Alpha. As a result of the CFA, modification indexes were examined and items with high error covariance’s were matched (e9-e10, e13-e14, e16-e20). After the modification the results were as follows: χ2/df(χ2/df=1.56) and other fit indexes: AGFI=0.85, GFI=0.87, NFI=0.95, TLI=0.98, CFI=0.98 and RMSEA=0.050. Cronbach’s alpha reliability coefficient was found as 0.93. Consequently after the findings, PFLS could be declared to be used in leisure research as a valid and reliable measurement tool with its 25 items and one factor structure. ​Extended English summary is in the end of Full Text PDF (TURKISH) file. Özet Serbest zaman davranışının anlaşılmasında serbest zamanda algılanan özgürlük konusu önemli bir boyut olarak görülmektedir. Bu çalışmanın amacı, “Serbest Zamanda Algılanan Özgürlük Ölçeği (SZAÖÖ)”nin geçerliğinin doğrulayıcı faktör analizi (DFA) ile sınanmasıdır. Araştırmanın çalışma grubu 228 üniversite öğrencisinden oluşturmaktadır. Ölçeğin güvenirliğini belirlemek için ise Cronbach alfa iç tutarlık katsayısı hesaplanmıştır. DFA sonucu, modifikasyon endekslerine bakılarak yüksek hata kovaryanslarına sahip maddeler birbirleri ile eşleştirilmiştir (e9-e10, e13-e14, e16-e20). Yapılan modifikasyon endekslerine göre χ2/df (χ2/df=1.56) ve diğer uyum indeks değerleri: AGFI=0.85, GFI=0.87, NFI=0.95, TLI=0.98, CFI=0.98 ve RMSEA=0.050 olarak tespit edilmiştir. Ölçeğin güvenirlik kat sayısı 0.93 olarak saptanmıştır. Araştırma sonucu, 25 madde ve tek faktörden oluşan SZAÖÖ’nin geçerli ve güvenilir bir ölçüm aracı olduğu söylenebilir.
Effects of Mindfulness with Gayatri Mantra on Decreasing Anxiety in the Elderly
Authors: Ketut Candrawati Sang Ayu , Dwidiyanti Meidiana , Widyastuti Rita Hadi 
Published: December 2019

Background: Anxiety is one of the psychological problems which can develop in the elderly. If left untreated, it can decrease the productivity and quality of life. Mindfulness with Gayatri mantra is such a complementary therapy which is effective to reduce anxiety in the elderly. Objective: The purpose of this study was to determine the effects of mindfulness with Gayatri mantra on decreasing anxiety in the elderly Hindus in Bali, Indonesia. Methods: This study employed a one group pre and posttest quasi-experimental design and involved 34 elderly people recruited using a purposive sampling technique. Anxiety was measured using the Geriatric Anxiety Scale (GAS). A t-test statistical analysis was used to analyze the data. Results: Results showed that there were significant effects of mindfulness with Gayatri mantra on decreasing the anxiety in the elderly Hindus in Bali with a p-value of 0.000 (α-value = 0.05). Conclusion: Mindfulness with Gayatri mantra could decrease anxiety in the elderly Hindus. This therapy can be used as an alternative to prevent the recurrence of anxiety in the elderly.
HOPS/TMUB1 retains p53 in the cytoplasm and sustains p53‐dependent mitochondrial apoptosis
Authors: Castelli Marilena , Piobbico Danilo , Chiacchiaretta Martina , Brunacci Cinzia , Pieroni Stefania , Bartoli Daniela , Gargaro Marco , Fallarino Francesca , Puccetti Paolo , Soddu Silvia , Della‐Fazia Maria Agnese , Servillo Giuseppe 
Published: December 2019

AbstractApoptotic signalling by p53 occurs at both transcriptional and non‐transcriptional levels, as p53 may act as a direct apoptogenic stimulus via activation of the intrinsic mitochondrial pathway. HOPS is a highly conserved, ubiquitously expressed shuttling protein with an ubiquitin‐like domain. We generated Hops−/− mice and observed that they are viable with no apparent phenotypic defects. However, when treated with chemotherapeutic agents, Hops−/− mice display a significant reduction in apoptosis, suggesting an impaired ability to respond to genotoxic stressors. We show that HOPS acts as a regulator of cytoplasmic p53 levels and function. By binding p53, HOPS inhibits p53 proteasomal degradation and favours p53 recruitment to mitochondria and apoptosis induction. By interfering with importin α, HOPS further increases p53 cytoplasmic levels. Thus, HOPS promotes the p53‐dependent mitochondrial apoptosis pathway by preserving cytoplasmic p53 from both degradation and nuclear uptake.
SMC5/6 acts jointly with Fanconi anemia factors to support DNA repair and genome stability
Authors: Rossi Francesco , Helbling‐Leclerc Anne , Kawasumi Ryotaro , Jegadesan Nanda Kumar , Xu Xinlin , Devulder Pierre , Abe Takuya , Takata Minoru , Xu Dongyi , Rosselli Filippo , Branzei Dana 
Published: December 2019

AbstractSMC5/6 function in genome integrity remains elusive. Here, we show that SMC5 dysfunction in avian DT40 B cells causes mitotic delay and hypersensitivity toward DNA intra‐ and inter‐strand crosslinkers (ICLs), with smc5 mutants being epistatic to FANCC and FANCM mutations affecting the Fanconi anemia (FA) pathway. Mutations in the checkpoint clamp loader RAD17 and the DNA helicase DDX11, acting in an FA‐like pathway, do not aggravate the damage sensitivity caused by SMC5 dysfunction in DT40 cells. SMC5/6 knockdown in HeLa cells causes MMC sensitivity, increases nuclear bridges, micronuclei, and mitotic catastrophes in a manner similar and non‐additive to FANCD2 knockdown. In both DT40 and HeLa systems, SMC5/6 deficiency does not affect FANCD2 ubiquitylation and, unlike FANCD2 depletion, RAD51 focus formation. SMC5/6 components further physically interact with FANCD2‐I in human cells. Altogether, our data suggest that SMC5/6 functions jointly with the FA pathway to support genome integrity and DNA repair and may be implicated in FA or FA‐related human disorders.
CrRLK1L receptor‐like kinases HERK1 and ANJEA are female determinants of pollen tube reception
Authors: Galindo‐Trigo Sergio , Blanco‐Touriñán Noel , DeFalco Thomas A , Wells Eloise S , Gray Julie E , Zipfel Cyril , Smith Lisa M 
Published: December 2019

AbstractCommunication between the gametophytes is vital for angiosperm fertilisation. Multiple CrRLK1L‐type receptor kinases prevent premature pollen tube burst, while another CrRLK1L protein, FERONIA (FER), is required for pollen tube reception in the female gametophyte. We report here the identification of two additional CrRLK1L homologues, HERCULES RECEPTOR KINASE 1 (HERK1) and ANJEA (ANJ), which act redundantly to promote pollen tube growth arrest at the synergid cells. HERK1 and ANJ localise to the filiform apparatus of the synergid cells in unfertilised ovules, and in herk1 anj mutants, a majority of ovules remain unfertilised due to pollen tube overgrowth, together indicating that HERK1 and ANJ act as female determinants for fertilisation. As in fer mutants, the synergid cell‐specific, endomembrane protein NORTIA (NTA) is not relocalised after pollen tube reception; however, unlike fer mutants, reactive oxygen species levels are unaffected in herk1 anj double mutants. Both ANJ and HERK1 associate with FER and its proposed co‐receptor LORELEI (LRE) in planta. Together, our data indicate that HERK1 and ANJ act with FER to mediate female–male gametophyte interactions during plant fertilisation.
ORGANIZATIONAL AND ECONOMIC MECHANISMS OF TRANSPORT SYSTEM DEVELOPMENT BASED ON LOGISTICS
Authors: IRTYSHCHEVA INNA , ISHCHENKO OLENA , BARABANOVA JULIA 
Published: December 2019

It is determined that the existence of a developed transport and logistics infrastructure is one of the defining dominants of the effective functioning of the transport and logistics system at the regional, national and international level, provides effective supply, marketing, production and social communications between the subjects of economic activity.
It is proved that the main directions of state policy implementation in the field of transport and logistics are: directions of innovative development of transport and logistics technologies on energy-saving and environmentally safe principles; construction of efficient economic systems in accordance with the principles of logistics and marketing; development of strategic planning; improvement of regulatory policy.
Institutional, organizational and economic mechanisms for ensuring the effective development of national transport and logistics systems have been researched and systematized, among which the following have been identified as priorities: the development of public-private partnerships and decentralization reform, which will solve the problems of financing infrastructure development, the formation of multi-branch integration structures (transport-logistics clusters, transport hubs and logistics-outsourcing platforms), which will improve the quality of transport and logistics services, intensification of the integration processes of the transport and logistics system in the international transport of the network, which will increase the competitiveness of the national economy, increase in productivity of transit potential and attraction of foreign investments in the development of the industry.
INFORMATION-ANALYTICAL PROVISION OF FINANCIAL SECURITY OF INDUSTRIAL ENTERPRISES: DETERMINANTS, EVALUATION OF INDICATORS AND MECHANISMS OF STRENGTH
Authors: VIVCHAR OKSANA , KRZYWKOWSKA JUSTYNA , MYKHAILYSHYN LILIIA , KOHUT-FERENS OKSANA 
Published: December 2019

Conceptual aspects of industrial enterprises financial security are considered, features of industrial enterprises financial security information and analytical support functioning are determined. On the basis of which a structural and logical scheme of information and analytical support of an industrial enterprise financial security in modern transformational conditions is proposed.
The analysis of the current state of major external and internal threats identification is carried out. Based on the results of the analysis, it was found that the most risky components of an industrial enterprise financial security are investment and credit, since these components carry the greatest number of risks.
Also, a comprehensive analytical assessment of the information and analytical support formation of the country’s Western region business structures financial security was made. The calculations make it possible to identify the main problematic aspects of the functioning of enterprises and threats to their financial security and to develop measures to strengthen it. The economic efficiency of the information and analytical support system introduction of industrial enterprises financial security with consideration of strategic and tactical vectors of development, and also depends on completeness, reliability, timeliness of the information component. The algorithm of forming information and analytical support of industrial enterprises financial security assessment with consideration of software is investigated. On the basis of which a multi-vector mechanism of information and analytical support of industrial enterprises financial security in modern conditions of turbulence of economic processes is proposed. This will make the decision-makers informed, both strategic and tactical, operational.
Cybersex use and problematic cybersex use among young Swiss men: Associations with sociodemographic, sexual, and psychological factors
Authors: Studer Joseph , Marmet Simon , Wicki Matthias , Gmel Gerhard 
Published: December 2019

Background and aims
Cybersex use (CU) is highly prevalent in Switzerland’s population, particularly among young men. CU may have negative consequences if it gets out of control. This study estimated prevalence of CU, frequency of CU (FCU), and problematic CU (PCU) and their correlates.

Methods
A non-selective sample of young Swiss men (N = 5,332, mean age = 25.45) completed a questionnaire assessing FCU and PCU, sociodemographics (age, linguistic region, and education), sexuality (being in a relationship, number of sexual partners, and sexual orientation), dysfunctional coping (denial, self-distraction, behavioral disengagement, and self-blame), and personality traits (aggression/hostility, sociability, anxiety/neuroticism, and sensation seeking). Associations were tested using hurdle and negative binomial regression models.

Results
At least monthly CU was reported by 78.6% of participants. CU was associated positively with post-secondary schooling (vs. primary schooling), German-speaking (vs. French-speaking), homosexuality, bisexuality (vs. heterosexuality), more than one sexual partner (vs. one), dysfunctional coping (except denial), and all personality traits except sociability, but negatively with being in a relationship (vs. not), age, and sociability. FCU was associated positively with homosexuality, bisexuality, no or more than one sexual partner, dysfunctional coping (except denial), and all personality traits except sociability, but negatively with age, being in a relationship, and sociability. PCU was associated positively with bisexuality, four or more sexual partners, dysfunctional coping, and all personality traits except sociability, but negatively with German-speaking and sociability.

Discussion and conclusions
CU should be viewed in light of its associations with sociodemographic, sexual, and psychological factors. Healthcare professionals should consider these aspects to adapt their interventions to patients’ needs.
Long-term results of surgical brain revascularization in patients with chronic cerebral insufficiency
Authors: Kudryashova T. A. , Tokarev A. S. , Lukyanchikov V. A. , Polunina N. A. , Senko I. V. , Dalibaldyan V. A. , Guseynova G. K. , Kudryashova N. E. , Muslimov R. Sh. 
Published: December 2019

The study objective is to evaluate long-term effectiveness of extracranial-intracranial (EC-IC) bypass in patients with symptomatic occlusion of the internal carotid artery (ICA).Materials and methods. From 2013 to 2015, 129 patients (aged 41 to 78, average age – 60 years) were applied EC-IC bypass on the side of ICA symptomatic occlusion at the Department of Neurosurgery of N.V. Sklifosovsky Research Institute for Emergency Medicine. We revealed right ICA occlusion in 54 patients, left ICA occlusion – in 67, bilateral occlusion – in 8. Symptomatic ICA occlusion was 5 times more often in men. We assessed neurological status in 1, 2, and 3 years using modified Rankin Scale, National Institutes of Health Stroke Scale, and Rivermead Mobility Index. Computed tomography (CT) angiography of extracranial and intracranial arteries, ultrasound of the anastomosis zone, single-photon emission computed tomography (SPECT) were performed.Results. In the early postoperative period, according to CT angiography and ultrasound, the anastomosis functioned in 125 (97 %) patients; improvement of regional cerebral perfusion according to SPECT was observed in all examined patients (n = 62). We examined 31 patients in the remote postoperative period. According to CT angiography and ultrasound, anastomosis functioned in 30 (97 %) patients, 30 (97 %) patients demonstrated positive dynamics of neurological status and brain perfusion. There were no repeated ischemic-type cerebral circulatory disorders and repeated transient ischemic attacks in the long-term postoperative period.Conclusion. Positive dynamics after EC-IC bypass was revealed both in early and in distant periods (within 1–3 years). During the surgery, it is necessary to take into account cases of ischemic strokes or transient ischemic attack, ICA occlusion according to CT angiography, a decrease in cerebrovascular reserve (<10 %) according to brain SPECT when tested with acetazolamide. To prevent complications, EC-IC bypass should not be used in patients with severe neurological impairments and concomitant pathology. Properly selected patients and postoperative drug therapy helps prevent repeated ischemic cerebral circulatory disorders.Conflict of interest. The authors declare no conflict of interest.Informed consent. All patients gave written informed consent to participate in the study.
Cases of vision loss after bifrontal access
Authors: Varfolomeev D. I. , Dubovoy A. V. , Sosnov A. O. , Nakhabin O. Yu. , Istomina T. K. 
Published: December 2019

The objective is to present 2 clinical cases of complete vision loss after bifrontal access during craniotomy due to vascular brain pathology.Materials and methods. In one case, a bifrontal skin incision was used during subfrontal craniotomy to remove frontal lobe arteriovenous malformation, in the other one – to apply intracranial side-to-side anastomosis between A3 segments of both anterior cerebral arteries, and to clip proximal aneurysms of the anterior connecting artery and the anterior cerebral artery on the right. After the surgery, patients developed bilateral amaurosis and ophthalmoplegia. We analyzed data on patients’ general clinical condition and their ophthalmological status prior to the surgery, as well as surgical videos and anesthesia records.Results. Intraoperative iatrogenic damage of cranial nerves and arteries was excluded. We distinguished that a suspected intraoperative factor, playing a decisive role, was a piece of skin applying direct pressure on the eyeballs. It was removed during the surgery.Conclusion. To prevent the development of such a complication as vision loss, it is necessary to carefully evaluate all possible risks at preoperative and intraoperative stages. During the surgery, all organs and systems at risk should be monitored. It is important to prevent a sudden drop in blood pressure and massive blood loss. During craniotomy, any eyeballs compression must be avoided.Conflict of interest. The authors declare no conflict of interest.Informed consent. All patients gave written informed consent to publication of their data.
Comparison of various pressure methods along with aspiration in treatment of auricular seroma
Authors: Modi Niral R. , Tota Sanjay M. 
Published: December 2019

<p class="abstract"><strong>Background:</strong> Auricular seroma or pseudocyst is soft cystic swelling on the pinna due to collection of intra cartilaginous fluid. The successful management of auricular seroma by aspiration and pressure remains a challenge as this disease has high recurrence rate.</p><p class="abstract"><strong>Methods:</strong> A total 28 patients with auricular seroma were treated by aspiration and different methods of pressure modalities as corrugated rubber splint, button, mastoid dressing and plaster of paris and their results were compared in this study.</p><p class="abstract"><strong>Results:</strong> No any recurrence of seroma and any complication occur after rubber splint pressure application. Post procedure complain like fever, pain, oedema, perichondritis and recurrence are more present in button, mastoid dressing and plaster of Paris pressure application.</p><p><strong>Conclusions:</strong> Aspiration and pressure application with rubber splint provides very simple, minimally invasive and effective management of auricular seroma. It is cost effective give uniform pressure and less traumatic to skin. Pressure with rubber splint method has low recurrence rate and as there is no need of mastoid bandage so less social embracement. </p>
Role of parental socio-educational factors on prevalence of paediatric otological disorders
Authors: Philip Jeeva Thankom , Renjit Rejee Ebenezer 
Published: December 2019

<p class="abstract"><strong>Background:</strong> Parental socioeconomic status, often designated by education and occupation is likely to have significant implications in children’s otological health. Hence the present school screening study was formulated in an attempt to establish the role of these factors on the prevalence of various ear diseases and related hearing impairment in children.</p><p class="abstract"><strong>Methods:</strong> A total of 346 lower primary school children, in the age group of 5-10 years were included in this cross sectional study.<strong> </strong>Details pertaining to the socioeconomic background of children were collected by questionnaire method. All children were initially evaluated by otoscopy and tuning fork testing and those having equivocal or abnormal tuning fork test results were subjected to pure tone audiometry and tympanometry. </p><p class="abstract"><strong>Results:</strong> There was significantly higher prevalence of hearing impairment among children of mothers with lower maternal educational status (13.2% versus 6.3%, (p=0.04, Odds ratio (95% CI) 2.27 (1.004-5.13)). Normal ear findings were noticed significantly higher among children with higher paternal (62.3% versus 47.7%) and maternal (59.1% versus 45.7%) educational status.</p><p class="abstract"><strong>Conclusions:</strong> Favourable parental socio-educational factors, especially maternal education have a significant positive impact on children’s otological health.</p><p> </p>