bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Prognostic Nutritional Index on Survival in Recurrent High-Grade Glial Tumors Treated with Systemic Treatment
Authors: Alan Ozkan , Telli Tugba Akin , Basoglu Tugba , Arikan Rukiye , Demircan Nazim Can , Ercelep Ozlem , Bozkurt Suheyla , Atasoy Beste Melek , Dane Faysal , Yumuk Perran Fulden 
Published: April 2020

Abstract
Background: Primary brain tumors are relatively rare malignancy, with high-grade gliomas (glioblastoma multiforme and anaplastic gliomas) are the most common types . We aimed to evaluate the prognostic value of Prognostic Nutritional Index (PNI), which is calculated by lymphocyte count and albumin, in recurrent high-grade glioma patients treated with systemic treatment.Methods: Data of 92 patients with recurrent high-grade glioma who received systemic treatment and followed in our clinic between 2012-2018 was retrospectively collected and analyzed. PNI was calculated as: [(10 × serum albumin (g/dL)) + (0.005 × total lymphocyte count)]. Patients were categorized according to the median PNI value. We investigated the prognostic role of PNI groups, and survival outcomes.Results: Median value of PNI was 46.02, and median follow-up duration was 9 months (1-68 months). Median overall survival (OS) was 8.1 months (95%CI: 6.04-10.3). Median OS was significantly longer in patients with PNI> 46.02 compared to patients with PNI ≤ 46.02 (13.9 months (95%CI: 9.8-18.1), and 6.07 months (95%CI: 4.3-7.7), p=0.01, respectively). In multivariate analysis, PNI was found to be an independent prognostic factor for OS [HR:0.54(95%CI:0.3-0.97), p=0.03)].Conclusion: In our study, the PNI was found to be an independent prognostic biomarker in patients with recurrent high-grade gliomas, but further prospective trials are necessary to validate its prognostic role.
Neural Adhesion Molecule Close Homolog of L1 Deficiency Exacerbates DSS-Induced Colitis in Mice
Authors: Han Ying , Zhu Ling-Ling , Wang Xiaomeng , Xiang Cheng , Zhao Ming , Zhao Tong , Guo Liang , Liu Dan , Wu Kuiwu , Fan Ming , Shi Ming 
Published: April 2020

Abstract
Background: The cell adhesion molecule CHL1, which belongs to the immunoglobulin superfamily, functions in a variety of physiological and pathological processes including neural development, tissue injury and repair. Recently, we found CHL1 was co-localized with GFAP positive cells in mouse colon tissue. Methods: Here, Colon tissues were collected from CHL1+/+ , CHL1+/- and CHL1-/- mice after dextran sodium sulfate (DSS) induced to investigate the effects of CHL1 on the development of DSS-induced colitis. Results: The data showed that CHL1 expression was increased in distal colon in a time-dependent manner after DSS-treatment. CHL1 deficiency induced more pronounced colitis features, an exacerbation of inflammation and damage to colonic tissues in DSS-induced mouse than that of wild type mouse. Moreover, CHL1-/- mice showed a remarkable increase of neutrophil and macrophage infiltration into colonic tissues, and then result in more severe damage to the intestinal epithelial cells and FITC leakage in CHL1 deficiency mice than that in WT mouse. Conclusions: Our results revealed a distinct colonic role for CHL1 in regulating DSS-induced colitis, CHL1 deficiency exacerbates DSS-induced colitis in mice, indicating that CHL1 may be an attractive therapeutic target for IBD.
Characteristics of online medical care consultation for pregnant women during the COVID-19 outbreak: a cross-sectional study
Authors: Chen Miaomiao , Liu Xiyao , Zhang Jun , Sun Guoqiang , Gao Ying , Shi Yuan , Baker Philip N. , Zeng Jing , Zheng Yangxi , Luo Xin , Qi Hongbo 
Published: April 2020

Abstract
Background

During the Coronavirus Disease 2019 (COVID-19) outbreak, emergency traffic bans limited accessibility of some medical resource for pregnant women. Fear of viral transmission also prevented pregnant women from seeking routine antenatal care (ANC). This study described the needs of pregnant women and the contents of online obstetric consultation in representative areas with various severity of the epidemic in China.

Methods

From February 10 th to 23 rd , we collected data on online obstetric consultations and women’s satisfaction in mild, moderate and severe epidemic areas through an e-health provider’s platform. Information on women’s needs, contents of the consultation and satisfaction were collected and compared by epidemic areas.

Results

A total of 2599 pregnant women participated in this study, of whom 448, 1322 and 819 women were from the mild, moderate and severe epidemic areas, respectively. The distributions of the amount of online consultation were significantly different not only in different areas, but also in different trimesters. The more severe the epidemic was and the more advanced the pregnancy was, the higher the amount of second category (changed their schedules of ANC and/or delivery as well as method of delivery) was. 957 participants completed a satisfaction survey. For most of the participants, it’s their first time to use the e-health, and nearly 90% participants were completely or mostly satisfied with the online consultation.

Conclusions

Our study found that during the outbreak, many pregnant women had changed their scheduled ANC visits without authorization, and the more serious the epidemic was, the more common it occurred. The needs for online consultation was substantial. In order to prevent irreversible obstetric adverse events, an appropriate ANC contingency plan with e-health services is highly recommended during the Public Health Emergency of International Concern (PHEIC).
Evaluation for hypocenter estimation error in the southwestern Kuril trench using Japan and Russia joint seismic data
Authors: Ichiyanagi Masayoshi , Valentin Mikhaylov , Kostylev Dmitry , Levin Yuri , Takahashi Hiroaki 
Published: April 2020

Abstract
The southwestern Kuril trench is seismically active due to the subduction of the Pacific plate. Great earthquakes in this zone have frequently induced fatal disasters. Seismic monitoring and hypocenter catalogues provide fundamental information on earthquake occurrence and disaster mitigation. Real-time hypocenter and magnitude estimates are extremely crucial data for tsunami warning systems. However, this region is located in the international border zone between Japan and Russia. The Japan Meteorological Agency and Russian Academy of Sciences have routinely determined hypocenters and issued earthquake information independently. Waveform data have not yet been exchanged internationally in real time. Here, we evaluated how a hypothetical Japan-Russia joint seismic network could potentially improve the hypocenter estimation accuracy. Experiments using numerical and observed data indicated that the joint network extended the distance over which hypocenters can be accurately determined over 100 km eastward compared to the Japan network only. This fact suggests that joint seismic data have the potential to improve the hypocenter accuracy in this region, which would provide improved performance in gathering disaster information at the moment of a tsunami warning.
Candida tropicalis distribution and drug resistance correlated to ERG11 and UPC2 expression
Authors: Wang Dan , An Na , Yang Yuwei , Yang Xianggui , Fan Yingzi , Feng Jiafu 
Published: April 2020

Abstract
Objective: This study is to analyze the distribution characteristics and drug resistance of Candida tropicalis, and the relationship between ERG11 and UPC2 expression and the resistance to azole.Methods: The Candida tropicalis were cultured and identified by the Sabouraud Agar Medium, CHROM Agar Candida and France Bio-Mérieux ATB test. The total RNA of the collected strains was extracted, and the ERG11 and UPC2 mRNA expression levels were analyzed by the quantitative real-time PCR. Results: Totally 2872 clinical isolates of Candida, including 319 strains of Candida tropicalis were analyzed herein, which were mainly distributed in the Departments of Respiratory Medicine and ICU. The specimen type was mainly based on the airway secretion, and the detection trend in four years was mainly related to the type of the departments and specimens. The resistance rates of Candida tropicalis to fluconazole, itraconazole and voriconazole have been increasing year by year. The mRNA expression levels of ERG11 and UPC2 in the fluconazole resistant group were significantly higher than the sensitive group. In addition, there was a significant linear positive correlation between these two genes in the fluconazole resistant group.Conclusions: Over-expression of ERG11 and UPC2 genes in Candida tropicalis could increase the resistance to antifungal drugs. The routine detection of ERG11 and UPC2 for high-risk patients in the key departments would provide theoretical basis for the rational application of antifungal drugs.
The Association Between Chiropractic Conservatism and the Ability to make Appropriate Clinical decisions: A Survey on Chiropractic Students in Denmark
Authors: Nim Casper Glissmann , O'Neill Søren , Lauridsen Henrik Hein , Goncalves Guillaume , Jensen Rikke Krüger , Leboeuf-Yde Charlotte 
Published: April 2020

Abstract
Background We investigated whether a university-based educational system would overrule the strong link (odds ratios >20) between chiropractic conservatism and the inability to recognize non-indications to chiropractic treatment that had been shown to exist in a previous study of a private chiropractic college. We i) sought to define the clinical decision profile of the students in a university-based course embedded in a medical school, and ii) investigated whether students’ clinical judgment was affected by their conservatism score determined from a ten item questionnaire and collapsed into four categories.Methods In a cross-sectional survey, 3 rd to 5 th year chiropractic students, attending the University of Southern Denmark and recently graduated interns were categorized into four levels of conservatism, which were cross-tabulated with the ability to answer appropriately on 9 cases concerning i) contra-indications, ii) non-indications and iii) indications to chiropractic treatment. Data were analyzed using logistic regression.Results In all, 146 participants (76%) completed the survey, of which 70% belonged in the two lowest conservatism groups with three outliers (group 4). Their ability to answer correctly to the clinical cases was generally acceptable. The level of conservatism (categories 1-3) was moderately (but not statistically significantly) associated with an inability to recognize non -indications to treatment (odds ratios ~3.5). Three outliers (category 4), however, answered inappropriately on the majority of the 9 clinical cases.Conclusions The Danish students’ clinical acumen in correctly judging the appropriateness of spinal manipulation in the clinical cases was fairly similar to that shown in the previous survey on chiropractic students attending a private college. Contrary to the findings at the private college, the level of conservatism did not have a strong association with the inability to recognize non-indications. Although a university-based education does not immunize its students against chiropractic conservatism, it does appear to attenuate its consequences on their clinical judgment.
Risk perception and behavioral response to COVID-19 in Iraqi Kurdistan Region
Authors: Shabu Sherzad , Amen Karwan M , Mahmood Kazhan I. , Shabila Nazar P. 
Published: April 2020

Abstract
Background Understanding how people perceive the risk of the coronavirus disease (COVID-19) outbreak and its impact on undertaking protective behavior can guide the public health policymakers in taking the required measures to limit the magnitude of this outbreak. This study aimed to understand the risk perception and the behavioral response of the university academics and students towards the COVID-19. Methods A self-administered online survey was conducted among the academic staff and university students in Iraqi Kurdistan Region. The survey questionnaire included eight main questions about the main aspects of personal risk perception and behavioral response to COVID-19 based on a five or nine-point ordinal scale. The eight questions included the number of contacts, the perceived threat level of COVID-19, personal risk perception, ability to avoid infection, frequency of undertaking the protective measures, adherence to the curfew, the negative impact of COVID-19 on life, and sources of obtaining information. Results A total of 976 individuals participated in the study with a mean age ± SD of 25.8±9.7 years. The respondents had the highest perceived threat level towards COVID-19 (mean score = 2.79) in comparison to other medical threats. Around 62% of respondents had no contacts outside their homes. A high percentage of the respondents perceived their risk of getting infection, serious illness, and death as highly unlikely (26.9%, 29.7%, and 41.7%, respectively). The percentage of the respondents who applied these measures frequently or always was high for most of the behaviors, except for wearing masks, wearing gloves, and avoiding touching face. There was a significant ( P <0.001) weak positive correlation between risk perception with protective behaviors; overall risk (beta = 0.080, r=0.189), risk of getting infection (beta=0.066, r=0.179), risk of getting serious illness (beta=0.070, r=0.176) and risk of death (beta=0.058, r=0.154). Conclusion The perceived risk of getting infection with COVID-19 is relatively low. The respondents follow protective behavior measures reasonably. However, the frequency of undertaking some important protective behaviors is relatively low. The risk perception of COVID-19 has a weakly positive impact on following protective behavior. Changing behavior remains a challenge even for the well educated and well aware people.
Development and Validation of a Diagnostic Nomogram to Predict COVID-19 Pneumonia
Authors: Wang Zhiyi , Weng Jie , Li Zhongwang , Hou Ruonan , Zhou Lebin , Ye Hua , Chen Ying , Yang Ting , Chen Daqing , Wang Liang , Liu Xiaodong , Shen Xian , Jin Shengwei 
Published: April 2020

Abstract

Background The COVID-19 virus is an emerging virus associated with severe respiratory illness first detected in December, 2019, and rapidly spread worldwide. The aim of this study was to establish an effective diagnostic nomogram for suspected COVID-19 pneumonia patients. Methods We used the LASSO aggression and multivariable logistic regression methods to explore the predictive factors associated with COVID-19 pneumonia, and established the diagnostic nomogram for COVID-19 pneumonia using multivariable regression. This diagnostic nomogram was assessed by the internal and external validation data set. Further, we plotted decision curves and clinical impact curve to evaluate the clinical usefulness of this diagnostic nomogram. Results The predictive factors including the epidemiological history, wedge-shaped or fan-shaped lesion parallel to or near the pleura, bilateral lower lobes, ground glass opacities, crazy paving pattern and white blood cell (WBC) count were contained in the nomogram. In the primary cohort, the C-statistic for predicting the probability of the COVID-19 pneumonia was 0.967, even higher than the C-statistic (0.961) in initial viral nucleic acid nomogram which was established using the univariable regression. The C-statistic was 0.848 in external validation cohort. Good calibration curves were observed for the prediction probability in the internal validation and external validation cohort. The nomogram both performed well in terms of discrimination and calibration. Moreover, decision curve and clinical impact curve were also beneficial for COVID-19 pneumonia patients. Conclusion Our nomogram can be used to predict COVID-19 pneumonia accurately and favourably.
Effects of oral administration of ticagrelor on the plasma level of adrenaline, histamine, serotonin, and acetylcholine in rat
Authors: Yang Xiuling , Guo Xue , Yanan Li , Jiaxi Li , Yue Liu 
Published: April 2020

Abstract

Background: Ticagrelor as a reversible P2Y12 receptor antagonist which plays an important role in the treatment of acute coronary syndrome (ACS). Dyspnea is one of the main adverse reactions of ticagrelor, however the mechanism is not clearly now. The aim of this study was to assess the possible relationship between ticagrelor-related dyspnea and some neurotransmitter in plasma which can contract the bronchial smooth muscle.Methods: The effects of ticagrelor on the plasma level of adrenaline, histamine, serotonin, and acetylcholine was studied in rats. Ticagrelor was administered at a loading dose of 24 mg/kg for the first time, and then maintenance dose 12 mg/kg, twice a day for 6 days. The plasma level of adrenaline, histamine, serotonin, and acetylcholine was determined by LC-MS/MS.Results: The plasma level of serotonin increased after ticagrelor administrating, especially at 1.5h ( p <0.05) reach the level of statistical significance. The level of serotonin in plasma was consistent with ticagrelor blood concentration. Meanwhile, ticagrelor can cause a decrease in the plasma concentration of histamine, and the change was statistically significant at time points of 1.5h, 3.5h and 10.5h respectively. The concentration of the adrenaline and acetylcholine had no change.Conclusions: The results of this study reveal that ticagrelor can increases blood serotonin levels and this may be a cause of dyspnea ticagrelor-related.
Serum NGAL is elevated in patients with asthma and persistent airflow obstruction
Authors: Kono Yuta , Kawagoe Junichiro , Togashi Yuki , Toriyama Kazutoshi , Yajima Chika , Tsuji Takao , Nakayama Hideaki , Kasagi Satoshi , Abe Shinji , Setoguchi Yasuhiro , Ishiwari Mayuko 
Published: April 2020

Abstract

Background: Neutrophilic airway inflammation is one of the features of severe asthma. Neutrophil gelatinase-associated lipocalin (NGAL), or lipocalin-2, is a glycoprotein associated with neutrophilic inflammation and can be detected in blood. Recently, blood NGAL levels have been reported to be elevated in chronic obstructive pulmonary disease. However, the clinical significance of serum NGAL levels in patients with asthma has not been elucidated. The aim of this study was to explore the association between serum NGAL level and clinical parameters in patients with asthma.Methods: Sixty-one non-smoking people with stable asthma were enrolled in this study. All patients underwent blood collection and pulmonary function tests. The associations between serum NGAL levels and clinical parameters were analyzed retrospectively. Results: Serum NGAL levels in patients with asthma and obstructive ventilatory disorder were higher than those in patients with asthma without obstructive ventilatory disorder (76.4 ± 51.4 ng/mL vs 39.3 ± 27.4 ng/mL, p=0.0019). Serum NGAL levels were correlated with forced expired flow at 50% of vital capacity %predicted and forced expired flow at 25% of vital capacity %predicted (r=-0.3373, p=0.0089 and r=-0.2900, p=0.0234, respectively). Results of a multiple regression analysis demonstrated that serum NGAL level was independently associated with obstructive ventilatory disorder.Conclusion: Serum NGAL levels were elevated in patients with asthma and obstructive ventilatory disorder. NGAL may be involved in airway remodeling possibly mediated by neutrophilic inflammation in asthma.
Thymoquinone Glucuronide Conjugated Magnetic Nanoparticle for Bimodal Imaging and Treatment of Cancer as a Novel Theranostic Platform
Authors: İnce İskender , Müftüler Zümrüt Biber , Medine E.İlker , Güldü Özge Kozguş , Takan Gökhan , Ergönül Ayşegül , Parlak Yasemin , Yıldırım Yeliz , Çakar Burcu , Bilgin Elvan Sayit , Aras Ömer , Göker Erdem , Ünak Perihan 
Published: April 2020

Background:
Theranostic oncology combines therapy and diagnosis and is a new field
of medicine that specifically targets the disease by using targeted molecules to destroy the cancerous
cells without damaging the surrounding healthy tissues.

Objective:
We aimed to develop a tool that exploits enzymatic TQ release from glucuronide (G)
for the imaging and treatment of lung cancer. We added magnetic nanoparticles (MNP) to enable
magnetic hyperthermia and MRI, as well as 131I to enable SPECT imaging and radionuclide therapy.

Methods:
A glucuronide derivative of thymoquinone (TQG) was enzymatically synthesized and
conjugated with the synthesized MNP and then radioiodinated with 131I. New Zealand white rabbits
were used in SPECT and MRI studies, while tumor modeling studies were performed on 6–7-
week-old nude mice utilized with bioluminescence imaging.

Results:
Fourier-transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR)
spectra confirmed the expected structures of TQG. The dimensions of nanoparticles were below 10
nm and they had rather polyhedral shapes. Nanoparticles were radioiodinated with 131I with over
95% yield. In imaging studies, in xenograft models, tumor volume was significantly reduced in
TQGMNP-treated mice but not in non-treated mice. Among mice treated intravenously with
TQGMNP, xenograft tumor models disappeared after 10 and 15 days, respectively.

Conclusion:
Our findings suggest that TQGMNP in solid, semi-solid and liquid formulations can
be developed using different radiolabeling nuclides for applications in multimodality imaging
(SPECT and MRI). By altering the characteristics of radionuclides, TQGMNP may ultimately be
used not only for diagnosis but also for the treatment of various cancers as an in vitro diagnostic kit
for the diagnosis of beta glucuronidase-rich cancers.
Konsumsi zat gizi dan parameter lemak tubuh pada wanita umur lebih dari 40 tahun
Authors: Adhi Kadek Tresna , Sutiari Ni Ketut , Lubis Dinar SM , Widarini Ni Putu , Putra I Gusti Ngurah Edi 
Published: April 2020

Food intake and body fat parameter among women older than 40 years old in DenpasarBackground: The prevalence of obesity in Indonesia tends to increase, particularly among women older than 40 years old.Objective: This study aimed to identify the associations between nutrient consumption and parameters of body fat among women in Denpasar.Methods: This was an observational analytic study with a cross-sectional approach. The population was women aged older than 40 years old in Denpasar with sampled population were members Dharma Wanita PDAM Kota Denpasar. Eighty out of 200 women were selected through systematic random sampling method. Variables collected in this study included women’s characteristics, nutrient consumption, and body fat parameters: body mass index (BMI), waist circumference (WC), and waist to hip ratio (WHR). Analysis of the relationship between nutrient consumption and body fat parameters using the Spearman Rank correlation.Results: This study found that the majority aged 41-50 years (83.8%), were Balinese (95.0%), have married (98.8%), did not use contraception (65.0%), completed higher education (63.8%), worked in informal sector (60.0%), had low income (65.0%), had no history of obesity (80.0%) and no family with degenerative diseases (73.8%). Based on the body fat parameters, most of the women were obese based on BMI (52.5%), WC (70.0%), and WHR (57.5%) categories. There was a significant association between fiber consumption and waist circumference (p=0.021).Conclusions: There was an association between fiber consumption and waist circumference, thus having a balanced and varied diet is recommended to prevent obesity and reduce risk factors for degenerative diseases.