bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does the optimization of a company's environmental performance reduce its systematic risk? New evidence from European listed companies
Authors: Djoutsa Wamba Léopold , Sahut Jean‐Michel , Braune Eric , Teulon Frédéric 
Published: February 2020

AbstractThe objective of this study is to examine the relationship between a company's environmental performance and its systematic risk. Using a sample of 351 European listed companies over the 2007–2015 period, the technique of principal components analysis is applied to calculate a synthetic global index of corporate environmental performance using 71 evaluation criteria suggested by the ASSET4 database. Using this same approach, subindices of the global index are calculated using the following ASSET4 dimensions: reduction of emissions, product innovation, and reduction of resource usage. To test the relationship between these variables and risk, panel data regression techniques are applied. Results indicate that the synthetic global index of environmental performance negatively affects the systematic risk of company. The decomposition of this global index into three subindices shows that those subindices relating to the reduction of environmental emissions and of resource usage make it possible to significantly reduce systematic risk, whereas the subindex relating to product innovation has a rather moderate effect. Thus, environmental performance, like governance, can be considered as an insurance mechanism for the company, which reduces the probability of events occurring, which negatively affect its cash flow and risks faced by shareholders.
Phendione–Transition‐Metal Complexes with Bipolar Redox Activity for Lithium Batteries
Authors: Lakraychi Alae Eddine , De Kreijger Simon , Gupta Deepak , Elias Benjamin , Vlad Alexandru 
Published: February 2020

Abstract1,10‐Phenanthroline‐5,6‐dione (phendione)‐based transition‐metal complexes are known for their use in pharmacological and catalysis applications. However, their application in electrochemical energy storage has not been investigated thus far. Herein, the feasibility of employing phendione–transition‐metal complexes was investigated for electrochemical charge storage by taking advantage of the reversible redox activity of both carbonyl groups and transition metal center, contributing to augmented charge storage. Interestingly, the chemistry of the counter ion in the studied complexes effectively tuned the solubility and improved the cycling stability. Although further studies are required to limit the solubility and active‐species shuttle, this study explores the bottlenecks of phendione–transition‐metal complexes as electrode materials for solid‐electrode‐format batteries.
Long‐lifespan Polyanionic Organic Cathodes for Highly Efficient Organic Sodium‐ion Batteries
Authors: Li Di , Tang Wu , Yong Chen Yue , Tan Zheng Hui , Wang Chuan , Fan Cong 
Published: February 2020

AbstractAn organic Na‐ion battery is reported with a polyanionic 9,10‐anthraquinone‐2,6‐disulfonate (Na2AQ26DS, 130 mAh g−1) cathode and the Na‐intercalated state (Na4TP) of sodium terephthalate (Na2TP, 255 mAh g−1) as the anode. The resulting full cells deliver the maximum discharge capacity of 131 mAh g−1cathode in 0.5–3.2 V, simultaneously maintaining the average value of ≈62 mAh g−1cathode during 1200 cycles (0.5 A g−1, ≈4 C). These results are among the best performing organic sodium‐ion full cells reported to date.
Curriculum integration: the challenges for primary and secondary schools in developing a new curriculum in the expressive arts
Authors: Kneen Judith , Breeze Thomas , Davies‐Barnes Sian , John Vivienne , Thayer Emma 
Published: February 2020

AbstractCurriculum integration is a feature of many new curricula that have emerged in different countries since around the turn of the millennium. It focuses on removing the boundaries between traditional subject specialisms, to enable more holistic and ‘joined‐up’ learning opportunities. This study draws on the experiences of a group of primary and secondary teachers in Wales, engaged in creating a framework for an integrated curriculum for expressive arts. Whilst the teachers are united in their ambition for establishing a curriculum that gives greater status to the arts, curriculum integration presents significant challenges, notably in how subject knowledge is understood and presented within an integrated curriculum. The teachers take different approaches to curriculum integration, with primary teachers favouring atransdisciplinaryapproach, with child‐led learning and themes taking precedence, and secondary teachers opting formultidisciplinaryapproaches, where the themes are organising devices but where subjects take priority. Differing practices suggest differing conceptions of subject knowledge and mastery within an integrated curriculum. Drawing, in particular, on Bernstein’s concepts relating to knowledge discourses, this paper suggests that the danger of an integrated curriculum is weakened disciplinary knowledge. Whilst this paper relates to the arts, the messages about curriculum integration might be applied more widely.
Transgenerational plasticity of inducible defences: Combined effects of grand‐parental, parental and current environments
Authors: Tariel Juliette , Plénet Sandrine , Luquet Émilien 
Published: February 2020

AbstractPhenotypic plasticity can occur across generations (transgenerational plasticity) when environments experienced by the previous generations influenced offspring phenotype. The evolutionary importance of transgenerational plasticity, especially regarding within‐generational plasticity, is a currently hot topic in the plasticity framework. How long an environmental effect can persist across generations and whether multigenerational effects are cumulative are primordial—for the evolutionary significance of transgenerational plasticity—but still unresolved questions. In this study, we investigated how the grand‐parental, parental and offspring exposures to predation cues shape the predator‐induced defences of offspring in the Physa acuta snail. We expected that the offspring phenotypes result from a three‐way interaction among grand‐parental, parental and offspring environments. We exposed three generations of snails without and with predator cues according to a full factorial design and measured offspring inducible defences. We found that both grand‐parental and parental exposures to predator cues impacted offspring antipredator defences, but their effects were not cumulative and depended on the defences considered. We also highlighted that the grand‐parental environment did alter reaction norms of offspring shell thickness, demonstrating an interaction between the grand‐parental transgenerational plasticity and the within‐generational plasticity. We concluded that the effects of multigenerational exposure to predator cues resulted on complex offspring phenotypic patterns which are difficult to relate to adaptive antipredator advantages.
Tritoroidal particle rings formation in open microfluidics induced by standing surface acoustic waves
Authors: Zheng Tengfei , Wang Chaohui , Xu Chaoping 
Published: February 2020

AbstractIn this paper, the particle movements in a sessile droplet induced by standing surface acoustic waves (SSAWs) are studied. Tritoroidal particle rings are formed under the interaction of acoustic field and electric field. The experimental results demonstrate that the electric field plays an important role in patterning nanoparticles. The electric field can define the droplet shape due to electrowetting. When the droplet approximates a hemisphere, the acoustic radiation force induced by SSAWs drives the particles to form tritoroidal particle rings. When the droplet approximates a convex plate, the drag force induced by acoustic steaming drives the particle to move. The results will be useful for better understanding the nanoparticle movements in a sessile droplet, which is important to explain the mechanism that SSAWs enhance reaction and crystallization in droplet.
Synergistically applying 1‐D modeling and CFD for designing industrial scale bubble column syngas bioreactors
Authors: Siebler Flora , Lapin Alexey , Takors Ralf 
Published: February 2020

AbstractThe reduction of greenhouse gas emissions and future perspectives of circular economy ask for new solutions to produce commodities and fine chemicals. Large‐scale bubble columns operated by gaseous substrates such as CO, CO2, and H2 to feed acetogens for product formations could be promising approaches. Valid in silico predictions of large‐scale performance are needed to dimension bioreactors properly taking into account biological constraints, too. This contribution deals with the trade‐off between sophisticated spatiotemporally resolved large‐scale simulations using computationally intensive Euler–Euler and Euler–Lagrange approaches and coarse‐grained 1‐D models enabling fast performance evaluations. It is shown that proper consideration of gas hold‐up is key to predict biological performance. Intrinsic bias of 1‐D models can be compensated by reconsideration of Sauter diameters derived from uniquely performed Euler–Lagrange computational fluid dynamics.
Microglial responses after phagocytosis: Escherichia coli bioparticles, but not cell debris or amyloid beta, induce matrix metalloproteinase‐9 secretion in cultured rat primary microglial cells
Authors: Hamanaka Gen , Kubo Tomoya , Ohtomo Ryo , Takase Hajime , Reyes‐Bricio Estefania , Oribe Shuntaro , Osumi Noriko , Lok Josephine , Lo Eng H. , Arai Ken 
Published: February 2020

AbstractUpon infection or brain damage, microglia are activated to play roles in immune responses, including phagocytosis and soluble factor release. However, little is known whether the event of phagocytosis could be a trigger for releasing soluble factors from microglia. In this study, we tested if microglia secrete a neurovascular mediator matrix metalloproteinase‐9 (MMP‐9) after phagocytosis in vitro. Primary microglial cultures were prepared from neonatal rat brains. Cultured microglia phagocytosed Escherichia coli bioparticles within 2 hr after incubation and started to secrete MMP‐9 at around 12 hr after the phagocytosis. A TLR4 inhibitor TAK242 suppressed the E. coli‐bioparticle‐induced MMP‐9 secretion. However, TAK242 did not change the engulfment of E. coli bioparticles in microglial cultures. Because lipopolysaccharides (LPS), the major component of the outer membrane of E. coli, also induced MMP‐9 secretion in a dose–response manner and because the response was inhibited by TAK242 treatment, we assumed that the LPS‐TLR4 pathway, which was activated by adhering to the substance, but not through the engulfing process of phagocytosis, would play a role in releasing MMP‐9 from microglia after E. coli bioparticle treatment. To support the finding that the engulfing step would not be a critical trigger for MMP‐9 secretion after the event of phagocytosis in microglia, we confirmed that cell debris and amyloid beta were both captured into microglia via phagocytosis, but neither of them induced MMP‐9 secretion from microglia. Taken together, these data demonstrate that microglial response in MMP‐9 secretion after phagocytosis differs depending on the types of particles/substances that microglia encountered.
Sphingosine 1‐phosphate promotes the proliferation of olfactory ensheathing cells through YAP signaling and participates in the formation of olfactory nerve layer
Authors: Bao Xiaomei , Xu Xingxing , Wu Qian , Zhang Jingjing , Feng Wenjin , Yang Danlu , Li Fayi , Lu Sheng , Liu Huitao , Shen Xiya , Zhang Fan , Xie Changnan , Wu Shiyang , Lv Zhaoting , Wang Wei , Li Hongjuan , Fang Yuanyuan , Wang Ying , Teng Honglin , Huang Zhihui 
Published: February 2020

AbstractOlfactory ensheathing cells (OECs) are unique glial cells with axonal growth‐promoting properties in the olfactory epithelium and olfactory bulb, covering the entire length of the olfactory nerve. The proliferation of OECs is necessary for the formation of the presumptive olfactory nerve layer (ONL) during development and OECs transplantation. However, the molecular mechanism underlying the regulation of OEC proliferation in the ONL still remains unknown. In the present study, we examined the role of sphingosine 1‐phosphate (S1P) and S1P receptors (S1PRs) on OEC proliferation. Initially, reverse transcription‐PCR (RT‐PCR), western blot and immunostaining revealed that S1PRs were highly expressed in the OECs in vitro and in vivo. Furthermore, we found that S1P treatment promoted the proliferation of primary cultured OECs mediated by S1PR1. Mechanistically, yes‐associated protein (YAP) was required for S1P‐induced OEC proliferation through RhoA signaling. Finally, conditional knockout of YAP in OECs reduced OEC proliferation in ONL, which impaired the axonal projection and growth of olfactory sensory neurons, and olfactory functions. Taken together, these results reveal a previously unrecognized function of S1P/RhoA/YAP pathway in the proliferation of OECs, contributing to the formation of ONL and the projection, growth, and function of olfactory sensory neurons during development.
Time‐varying nodal measures with temporal community structure: A cautionary note to avoid misinterpretation
Authors: Thompson William Hedley , Kastrati Granit , Finc Karolina , Wright Jessey , Shine James M. , Poldrack Russell A. 
Published: February 2020

AbstractIn network neuroscience, temporal network models have gained popularity. In these models, network properties have been related to cognition and behavior. Here, we demonstrate that calculating nodal properties that are dependent on temporal community structure (such as the participation coefficient [PC]) in time‐varying contexts can potentially lead to misleading results. Specifically, with regards to the participation coefficient, increases in integration can be inferred when the opposite is occurring. Further, we present a temporal extension to the PC measure (temporal PC) that circumnavigates this problem by jointly considering all community partitions assigned to a node through time. The proposed method allows us to track a node's integration through time while adjusting for the possible changes in the community structure of the overall network.
Clinical outcomes for larynx patients with cancer treated with refinement of high‐dose radiation treatment volumes
Authors: Burr Adam R. , Harari Paul M. , Haasl Alyx M. , Wieland Aaron M. , Bruce Justine Y. , Kimple Randall J. , Hartig Gregory K. , McCulloch Timothy M. , Witek Matthew E. 
Published: February 2020

AbstractBackgroundTo evaluate disease control, toxicities, and dose to dysphagia/aspiration risk structures (DARS) using a direct gross tumor volume (GTV70Gy) to planning target volume expansion (dPTV70Gy) for patients with squamous cell carcinoma of the larynx (LSCC).MethodsA retrospective review was performed on patients with LSCC treated between 2003 and 2018. Clinical outcomes, toxicities, and dosimetric data were analyzed.ResultsSeventy‐three patients were identified. Overall survival at 5‐years was 57.8%. Five‐year local and regional control was 79.8% and 88.2%, respectively. Distant metastatic‐only failure was 2.7%. Eighty percent of failures were 95% contained within the dPTV70Gy. Mean dose and the volume of DARS receiving 70 Gy was significantly lower for dPTV70Gy compared to a consensus‐defined PTV70Gy.DiscussionJudicious reduction in high‐dose target volumes can preserve high tumor control rates while reducing dose to normal surrounding structures underscoring the potential benefit of this approach in enabling local therapy intensification to improve locoregional control.
Synthesis of a New Class of Materials with a Regular (Periodic) Interconnected Microstructure
Authors: Shevchenko V. Ya. , Kovalchuk M. V. , Oryschenko A. S. 
Published: February 2020

AbstractThe scientific basis for the synthesis of a new class of materials with an regular (periodic) interconnected structure based on triply periodic surfaces of minimum energy is formulated. The analysis of chemical synthesis based on the reaction‐diffusion Turing reaction, which allows obtaining periodic microstructures.
Is a mother's recalled parental rearing behavior, her attributions of her child's behavior, and her psychopathology associated with her mother–child relationship quality?
Authors: Albers Carolin C. , Müller Jörg M. , Mehring Kathrin , Romer Georg 
Published: February 2020

ABSTRACTBackgroundThe mother–child relationship quality (MCRQ) may represent a transgenerational transmission mechanism of mental health problems. In this context, we examine the mother's recalled parental rearing behavior, actual attributions of her child's behavior, and her current psychopathology.MethodA clinical sample of mother–child dyads was assessed with the Questionnaire for the Assessment of Recalled Parental Rearing Behavior, the Parent Cognition Scale, and the Symptom Checklist at the Child Psychiatric Family Day Hospital for preschool children in Münster, Germany, at admission. MCRQ was assessed with the Parent–Infant Relationship Global Assessment Scale, a structured interview with the child (Strukturiertes Interview zur Erfassung der Kind‐Eltern‐Interaktion), and the Multiperspective Parent–Child Relationship Questionnaire.ResultsMultiple regression analyses showed no direct association between the mother's recalled parental rearing behavior and any measure of the MCRQ. However, maternal dysfunctional attributions about her child's behavior and her actual psychopathology showed the expected negative associations with the multiperspective measures of MCRQ. The relationship quality assessments did not correlate significantly with each other.ConclusionThe divergent measures of MCRQ, which seem to assess different aspects, are a barrier to investigate the association between the mother's recalled parental rearing behavior and MCRQ. However, low MCRQ is associated with increased maternal psychopathology and maternal dysfunctional attributions on child behavior.
Aldehyde dehydrogenase 2 deficiency significantly exacerbates tert‐butyl alcohol‐induced toxicity in mice
Authors: Lin Liping , Suda Megumi , Xu Chenlan , Zhang Yuehan , Yanagiba Yukie , Nie Jisheng , Nakajima Tamie , Weng Zuquan , Wang Rui‐Sheng 
Published: February 2020

AbstractOwing to the use of ethyl tert‐butyl ether (ETBE) as a fuel additive, the possible adverse effects of ETBE exposure have become a public concern. Our previous study showed that ETBE‐induced toxicity in aldehyde dehydrogenase 2 (Aldh2) gene knockout (KO) mice was caused by its primary metabolite acetaldehyde, which was toxic. However, it is unclear whether tert‐butyl alcohol (TBA), another main metabolite of ETBE, plays a role in ETBE‐induced toxicity. To investigate this relationship, we analyzed the changes of TBA concentrations in tissues after ETBE exposure, and then evaluated the toxicity after direct TBA treatment in both KO and wild‐type (WT) mice. An exposure to 500 ppm ETBE via inhalation resulted in the formation of its three metabolites, TBA, 2‐methyl‐1,2‐propanediol and ethanol, whose concentrations in the liver, brain, fat and testis of male KO mice were significantly higher than the corresponding concentrations observed in male WT mice. Direct treatment to TBA (20 mg/mL of drinking water) caused significant changes in relative organ weights and histopathology, and increased levels of genetic damages in both types of mice. These toxic effects were also seen in KO mice exposed to a lower concentration of TBA (5 mg/mL), which was associated with increased oxidative stress in serum (reduced glutathione and reduced glutathione/oxidized glutathione ratio decreased). Our findings indicate that ALDH2 is involved in the metabolism of ETBE and TBA, and ALDH2 deficiency could greatly increase the sensitivity to TBA‐induced toxicity.
Handheld volumetric manual compression‐based quantitative microelastography
Authors: Fang Qi , Frewer Luke , Zilkens Renate , Krajancich Brooke , Curatolo Andrea , Chin Lixin , Foo Ken Y. , Lakhiani Devina D. , Sanderson Rowan W. , Wijesinghe Philip , Anstie James D. , Dessauvagie Benjamin F. , Latham Bruce , Saunders Christobel M. , Kennedy Brendan F. 
Published: February 2020

AbstractCompression optical coherence elastography (OCE) typically requires a mechanical actuator to impart a controlled uniform strain to the sample. However, for handheld scanning, this adds complexity to the design of the probe and the actuator stroke limits the amount of strain that can be applied. In this work, we present a new volumetric imaging approach that utilizes bidirectional manual compression via the natural motion of the user's hand to induce strain to the sample, realizing compact, actuator‐free, handheld compression OCE. In this way, we are able to demonstrate rapid acquisition of three‐dimensional quantitative microelastography (QME) datasets of a tissue volume (6 × 6 × 1 mm3) in 3.4 seconds. We characterize the elasticity sensitivity of this freehand manual compression approach using a homogeneous silicone phantom and demonstrate comparable performance to a benchtop mounted, actuator‐based approach. In addition, we demonstrate handheld volumetric manual compression‐based QME on a tissue‐mimicking phantom with an embedded stiff inclusion and on freshly excised human breast specimens from both mastectomy and wide local excision (WLE) surgeries. Tissue results are coregistered with postoperative histology, verifying the capability of our approach to measure the elasticity of tissue and to distinguish stiff tumor from surrounding soft benign tissue.
Ex Vivo Organ Cultures as Models to Study Bone Biology
Authors: Bellido Teresita , Delgado‐Calle Jesus 
Published: February 2020

ABSTRACTThe integrity of the skeleton is maintained by the coordinated and balanced activities of the bone cells. Osteoclasts resorb bone, osteoblasts form bone, and osteocytes orchestrate the activities of osteoclasts and osteoblasts. A variety of in vitro approaches has been used in an attempt to reproduce the complex in vivo interactions among bone cells under physiological as well as pathological conditions and to test new therapies. Most cell culture systems lack the proper extracellular matrix, cellular diversity, and native spatial distribution of the components of the bone microenvironment. In contrast, ex vivo cultures of fragments of intact bone preserve key cell–cell and cell–matrix interactions and allow the study of bone cells in their natural 3D environment. Further, bone organ cultures predict the in vivo responses to genetic and pharmacologic interventions saving precious time and resources. Moreover, organ cultures using human bone reproduce human conditions and are a useful tool to test patient responses to therapeutic agents. Thus, these ex vivo approaches provide a platform to perform research in bone physiology and pathophysiology. In this review, we describe protocols optimized in our laboratories to establish ex vivo bone organ cultures and provide technical hints and suggestions. In addition, we present examples on how this technical approach can be employed to study osteocyte biology, drug responses in bone, cancer‐induced bone disease, and cross‐talk between bone and other organs © 2020 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.
Applying visual analytics to fraud detection using Benford's law
Authors: Goh Clarence 
Published: February 2020

AbstractBenford's law has been examined as a useful tool for detecting potential accounting fraud. In this article, I provide an introduction to Benford's law and examine how the first digit, second digit, and first‐two digits tests in Benford's law can be employed to detect potential accounting fraud. In addition, I also highlight, through a worked example, how Tableau, a visual analytics tool, can be used to perform Benford's law's first‐digit test to detect potential fraud.