bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case report of combination therapy with Azacytidine, Enasidenib and Venetoclax in primary refractory AML
Authors: Jasra Sakshi , Kazemi Mohammed , Shah Nishi , Chen Jiahao , Fehn Karen , Wang Yanhua , Mantzaris Ioannis , Kornblum Noah , Sica Alejandro , Bachier LizaMarie , Goldfinger Mendel , Gritsman Kira , Braunschweig Ira , Steidl Ulrich , Shastri Aditi , Verma Amit 
Published: January 2021

AbstractOptimal treatment of acute myeloid leukemia (AML) arising in elderly patients remains a challenge. FDA approval of Ivosidenib and Enasidenib, small molecule inhibitors of isocitrate dehydrogenase enzymes (IDH1 and 2) have opened new avenues of treatment. We present a 60-year-old woman with refractory AML, achieving complete response to the combination therapy of hypomethylating agent, Azacytidine with the IDH2 inhibitor, Enasidenib, and BCL2 inhibitor, Venetoclax. To our knowledge, this is the first case report of a patient with IDH2 mutated refractory AML achieving complete response to combination therapy with azacytidine, enasidenib and venetoclax.
Neglected tropical diseases activities in Africa in the COVID-19 era: the need for a “hybrid” approach in COVID-endemic times
Authors: Molyneux David , Bush Simon , Bannerman Ron , Downs Philip , Shu’aibu Joy , Boko-Collins Pelagie , Radvan Ioasia , Wohlgemuth Leah , Boyton Chris 
Published: January 2021

AbstractWith the coronavirus disease 2019 (COVID-19) pandemic showing no signs of abating, resuming neglected tropical disease (NTD) activities, particularly mass drug administration (MDA), is vital. Failure to resume activities will not only enhance the risk of NTD transmission, but will fail to leverage behaviour change messaging on the importance of hand and face washing and improved sanitation—a common strategy for several NTDs that also reduces the risk of COVID-19 spread. This so-called “hybrid approach” will demonstrate best practices for mitigating the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by incorporating physical distancing, use of masks, and frequent hand-washing in the delivery of medicines to endemic communities and support action against the transmission of the virus through water, sanitation and hygiene interventions promoted by NTD programmes. Unless MDA and morbidity management activities resume, achievement of NTD targets as projected in the WHO/NTD Roadmap (2021–2030) will be deferred, the aspirational goal of NTD programmes to enhance universal health coverage jeopardised and the call to ‘leave no one behind’ a hollow one. We outline what implementing this hybrid approach, which aims to strengthen health systems, and facilitate integration and cross-sector collaboration, can achieve based on work undertaken in several African countries.
All-soft multiaxial force sensor based on liquid metal for electronic skin
Authors: Kim Kyuyoung , Ahn Junseong , Jeong Yongrok , Choi Jungrak , Gul Osman , Park Inkyu 
Published: January 2021

AbstractElectronic skin (E-skin) capable of detecting various physical stimuli is required for monitoring external environments accurately. Here, we report an all-soft multiaxial force sensor based on liquid metal microchannel array for electronic skin applications. The proposed sensor is composed of stretchable elastomer and Galinstan, a eutectic gallium-indium alloy, providing a high mechanical flexibility and electro-mechanical durability. Liquid metal microchannel arrays are fabricated in multilayer and positioned along a dome structure to detect multi-directional forces, supported by numerical simulation results. By adjusting the height of the dome, we could control the response of the multiaxial sensor with respect to the deflection. As a demonstration of multiaxial force sensing, we were able to monitor the direction of multidirectional forces using a finger by the response of liquid metal microchannel arrays. This research could be applied to various fields including soft robotics, wearable devices, and smart prosthetics for artificial intelligent skin applications.
A sensitive HPLC-FLD method for the quantification of 6-O-demethylmenisporphine isolated from Menispermi Rhizoma in rat plasma
Authors: Wei Jinxia , Shao Jia , Li Yanan , Li Yubo 
Published: January 2021

Abstract
Background
To investigate the pharmacokinetics of 6-O-demethylmenisporphine, an oxoisoaporphine alkaloid with significant anti-tumor activities and isolated from Menispermi Rhizoma, a novel and sensitive HPLC assay was established for 6-O-demethylmenisporphine quantification in rat plasma.

Methods
Peak responses were detected by a highly selective and sensitive fluorescence detector with 426-nm excitation and 514-nm emission wavelengths. Curcumin was employed as the internal standard (IS). A Capcell Pak C18 column (150 mm × 4.6 mm i.d., 5 μm) and an isocratic elution procedure with a flow rate of 1.0 mL/min were used to exclude the endogenous interfering substance. Acetonitrile-water (68:32, v/v) containing 1% formic acid was employed as mobile phase. A 7-point calibration curve that covered the concentration range of 10–2500 ng/mL was constructed.

Results
A good linearity was observed with a correlation coefficient (r) of 0.9993. The lower limit of quantification for 6-O-demethylmenisporphine was 10 ng/mL. The mean recoveries of analyte in rat plasma exceeded 80.5%. The precision at four concentration levels was within 11.3% and the accuracy ranged from − 7.6 to 6.7%.

Conclusion
Using this new HPLC-FLD method, the investigation of plasma samples from rats following oral dosing of neat compound and Menispermi Rhizoma extract was successfully conducted. The results will provide a reference for the evaluation of preclinical safety of 6-O-demethylmenisporphine.
General practitioner practice-based pharmacist input to medicines optimisation in the UK: pragmatic, multicenter, randomised, controlled trial
Authors: Syafhan Nadia Farhanah , Al Azzam Sayer , Williams Steven D. , Wilson Wendy , Brady Jayne , Lawrence Peter , McCrudden Mark , Ahmed Mustafa , Scott Michael G. , Fleming Glenda , Hogg Anita , Scullin Claire , Horne Robert , Ahir Harblas , McElnay James C. 
Published: January 2021

AbstractBackgroundChanging demographics across the UK has led to general practitioners (GPs) managing increasing numbers of older patients with multi-morbidity and resultant polypharmacy. Through government led initiatives within the National Health Service, an increasing number of GP practices employ pharmacist support. The purpose of this study is to evaluate the impact of a medicines optimisation intervention, delivered by GP practice-based pharmacists, to patients at risk of medication-related problems (MRPs), on patient outcomes and healthcare costs.MethodsA multi-centre, randomised (normal care or pharmacist supplemented care) study in four regions of the UK, involving patients (n = 356) from eight GP practices, with a 6-month follow-up period. Participants were adult patients who were at risk of MRPs.ResultsMedian number of MRPs per intervention patient were reduced at the third assessment, i.e. 3 to 0.5 (p < 0.001) in patients who received the full intervention schedule. Medication Appropriateness Index (MAI) scores were reduced (medications more appropriate) for the intervention group, but not for control group patients (8 [4–13] to 5 [0–11] vs 8 [3–13] to 7 [3–12], respectively;p = 0.001). Using the intention-to-treat (ITT) approach, the number of telephone consultations in intervention group patients was reduced and different from the control group (1 [0–3] to 1 [0–2] vs 1 [0–2] to 1 [0–3],p = 0.020). No significant differences between groups were, however, found in unplanned hospital admissions, length of hospital stay, number of A&E attendances or outpatient visits. The mean overall healthcare cost per intervention patient fell from £1041.7 ± 1446.7 to £859.1 ± 1235.2 (p = 0.032). Cost utility analysis showed an incremental cost per patient of − £229.0 (95% CI − 594.6, 128.2) and a mean QALY gained of 0.024 (95% CI − 0.021 to 0.065), i.e. indicative of a health status gain at a reduced cost (2016/2017).ConclusionThe pharmacist service was effective in reducing MRPs, inappropriateness of medications and telephone consultations in general practice in a cost-effective manner.Trial registration:ClinicalTrials.Gov, NCT03241498. Registered 7 August 2017—Retrospectively registered,https://clinicaltrials.gov/ct2/show/NCT03241498
Exploring healthcare professionals’ knowledge, attitude, and practices towards pharmacovigilance: a cross-sectional survey
Authors: Hussain Rabia , Hassali Mohamed Azmi , Hashmi Furqan , Akram Tayyaba 
Published: January 2021

Abstract
Background
Spontaneous reporting of adverse drug reactions (ADRs) is a method of monitoring the safety of drugs and is the basic strategy for the post-marketing surveillance of the suspected drugs. Despite its importance, there is very little reporting of ADRs by healthcare professionals. The present study has evaluated the knowledge, attitude and practices of health care professionals (HCPs) regarding pharmacovigilance activities in Lahore, Pakistan.

Methods
A cross-sectional questionnaire-based survey was employed, and a convenience sampling was opted to collect the data among physicians, pharmacists and nurses working in tertiary care public hospitals of Lahore, Pakistan from September 2018 to January 2019.

Results
Of the 384 questionnaires distributed, 346 health care professionals responded to the questionnaire (90.10% response rate). Most participants had good knowledge about ADR reporting, but pharmacist had comparatively better knowledge than other HCPs regarding ADR (89.18%) pharmacovigilance system (81.08%), its centres (72.97%) and function (91.89%). Most of the participants exhibited positive attitude regarding ADR reporting, such as 49.1% of physicians (P < 0.05), 70.2% pharmacists and 76.1% nurses showed a positive attitude that they are the most important HCPs to report an ADR. About 64.3% of physicians (P < 0.05) emphasized that consulting other colleagues is important before reporting an ADR. Of all, 77.7% physicians, 75.7% pharmacists and 68% of nurses had positive attitude that ADR reporting is a professional obligation and 67.6% of the pharmacists stated that they have reported ADRs in their workplace and 77.2% nurses have verbally reported ADRs to the concerned personnel or department.

Conclusion
Among all HCPs, pharmacists had better knowledge about ADR reporting and pharmacovigilance. All HCPs had positive attitude and inclination towards ADR reporting. The discrepancies were observed in the practices related to ADR reporting, whereas most of the participants including physicians and nurses did not report any ADR. Based on the above, strategies are needed to educate, train, and empower the HCPs in the domain of pharmacovigilance.
Adhesively bonded joints of jute, glass and hybrid jute/glass fibre-reinforced polymer composites for automotive industry
Authors: de Queiroz H. F. M. , Banea M. D. , Cavalcanti D. K. K. 
Published: January 2021

AbstractNatural fibre-reinforced composites have attracted a great deal of attention by the automotive industry mainly due to their sustainable characteristics and low cost. The use of sustainable composites is expected to continuously increase in this area as the cost and weight of vehicles could be partially reduced by replacing glass fibre composites and aluminium with natural fibre composites. Adhesive bonding is the preferred joining method for composites and is increasingly used in the automotive industry. However, the literature on natural fibre reinforced polymer composite adhesive joints is scarce and needs further investigation. The main objective of this study was to investigate experimentally adhesively bonded joints made of natural, synthetic and interlaminar hybrid fibre-reinforced polymer composites. The effect of the number of the interlaminar synthetic layers required in order to match the bonded joint efficiency of a fully synthetic GFRP bonded joint was studied. It was found that the failure load of the hybrid jute/glass adherend joints increased by increasing the number of external synthetic layers (i.e. the failure load of hybrid 3-layer joint increased by 28.6% compared to hybrid 2-layer joint) and reached the pure synthetic adherends joints efficiency due to the optimum compromise between the adherend material property (i.e. stiffness and strength) and a diminished bondline peel stress state.
The influence of epoxy adhesive toughness on the strength of hybrid laminate adhesive joints
Authors: Carbas R. J. C. , Marques E. A. S. , da Silva L. F. M. 
Published: January 2021

AbstractThe use of composite materials in structural applications has significantly expanded in recent years. The transport industry accounts for an increasingly larger share of the final structural weight of vehicles, as manufacturers pursue improvements in fuel economy, lighter more efficient designs, and reduction of emissions. However, the delamination of adhesively bonded composite joints causes premature failure of the bond, inhibiting the use of its full potential and leading to inefficient and over-designed components. A hybrid composite metallic material technology is studied in this work, a method inspired in the fibre metal laminate concept, and which combines the best properties of FRPs and metal alloys. The hybrid composite-metallic adherends aims to increase the joint strength in the through thickness direction, minimise peel stresses and limit delamination. The objective of this work was to evaluate the performance of hybrid joints, bonded with different adhesives by comparing them against a reference joint using a conventional Carbon fibre reinforced polymer (CFRP) adherend. The joints were experimentally tested using a universal testing machine for a crosshead speed of 1 mm/min. Numerical models were developed, using the ABAQUS software, to study the behaviour of all joints studied. The numerical predictions of failure loads and modes were compared to the experimentally obtained results.
Lateral variations of electrical conductivity in the lower mantle constrained by Swarm and CryoSat-2 missions
Authors: Velímský Jakub , Knopp Ondřej 
Published: January 2021

AbstractThe electrical conductivity is an important geophysical parameter connected to the thermal, chemical, and mineralogical state of the Earth’s mantle. In this paper, we apply the previously developed methodology of forward and inverse EM induction modeling to the latest version of satellite-derived spherical harmonic coefficients of external and internal magnetic field, and obtain the first 3-D mantle conductivity models with contributions from Swarm and CryoSat-2 satellite data. We recover degree 3 conductivity structures which partially overlap with the shape of the large low-shear velocity provinces in the lower mantle.
Relationship between Na layer and CNA variations observed at Syowa, Antarctic
Authors: Tsuda T. T. , Tanaka Y. -M. , Tozu R. , Takizawa K. , Ejiri M. K. , Nishiyama T. , Kawahara T. D. , Nakamura T. 
Published: January 2021

AbstractWe have performed a statistical data analysis on relationship between simultaneous Na density data and cosmic noise absorption (CNA) data, which is an indicator for energetic particle precipitation, obtained at Syowa, Antarctic in 2000–2002. It is found that the Na densities around the topside of Na layers (above $$\sim 95 \,\hbox {km}$$

∼
95

km

height) tended to be smaller when the CNA was larger. The amounts of Na density responses, i.e., Na density decrease or Na loss, were increasing with magnetic local time (MLT) from dusk hours to dawn hours, and those of CNA responses, i.e., CNA increase, were also increasing with MLT. Thus, there were clear negative correlations between the Na density and CNA variations. These results indicate that the Na loss around the topside of Na layer would be induced by the energetic particle precipitation, and its effect would be more severe in dawn hours.
X-ray fluorescence core scanning, magnetic signatures, and organic geochemistry analyses of Ryukyu Trench sediments: turbidites and hemipelagites
Authors: Hsiung Kan-Hsi , Kanamatsu Toshiya , Ikehara Ken , Usami Kazuko , Horng Chorng-Shern , Ohkouchi Naohiko , Ogawa Nanako O. , Saito Saneatsu , Murayama Masafumi 
Published: January 2021

AbstractThe southwestern Ryukyu Trench represents the ultimate sink of sediments shed from Taiwan into the Philippine Sea, which are mainly transported to the trench by turbidity currents via submarine canyons. Here, we present trench turbidites intercalated with hemipelagites in a gravity pilot core and a piston core acquired on the Ryukyu Trench floor at 6147 m water depth. We performed X-ray fluorescence core scans (ITRAX profiles), magnetic measurements, and organic geochemistry analyses to discriminate turbidites from hemipelagites. We identified 36 turbidites (0.9–4.2 cm thick) based on visual core descriptions and Ca/Fe ratios in the ITRAX profiles. Three of these turbidites show magnetic signatures indicating the presence of pyrrhotite and peaks in the magnetic susceptibility profile, suggesting that Taiwan-sourced sediments are transported to the Ryukyu Trench by long-runout turbidity currents. Pyrrhotite is also present in hemipelagites of the upper part of the retrieved cores, indicating a dominant sediment source in Taiwan over the last several thousand years. Ca/Fe and Zr/Rb ratios in the ITRAX profiles mark distal turbidites (about 1–3 cm thick), and Zr/Rb peaks mainly reflect grain size changes. Detailed analyses of a representative turbidite show good correlation between Ca/Fe and Zr/Rb peaks with upward-coarsening and upward-fining trends that delimit the turbidite. Sedimentary organic matter in hemipelagites is characterized by higher total organic carbon and total nitrogen contents and higher δ13C values than that in turbidites. Our multi-proxy approach employing high-resolution XRF core scans to differentiate turbidites from hemipelagites contributes to establishing a comprehensive view of modern trench sedimentation from Taiwan to the southwestern Ryukyu Trench.
Back to the past: gains and losses in Brazilian society
Authors: Scalon Celi , Caetano André Junqueira , Chaves Hugo , Costa Luana 
Published: January 2021

AbstractDuring the first 15 years of the twenty-first century, Brazil’s economic growth and public policies were in the center of the debate on the growing “new middle class.” This new middle class is defined by people’s household income between the upper 10th percentile and the median (Neri, A Nova Classe Média, 2008). Although there has been a consensus about the increase in consumption and the improvement of living conditions for a significant proportion of the population, there is less agreement about the decline in inequality and the change in class distribution. Previous work was directed at challenging the very idea that Brazil had become a middle-class country during the first decade of this century, basically weighting class distribution against income distribution. In this article, we aim to step into the income distribution debate using six income groups as proportions of the median household per-capita income. Our data source is the National Household Sample Survey (PNAD-IBGE/Brazil) in 2001, 2008, and 2015. We analyze groups’ income distribution and characteristics using multinomial logistic models to take into account the effects of socioeconomic variables. We argue that there is significant stability in groups’ income structure during the period, revealing their resistance to inequalities (similar to the findings in the works of Piketty and Souza). We also indicate that the odds of being included in the upper-income categories are quite unequal, considering socioeconomic variables. Finally, we point out that the gains observed from 2001 to 2008 had faded by 2015 when the odds of being included in the upper-income categories were remarkably similar to those of 2001.
The nationalist-indigenous and colonial modernity: an assessment of two sociologists in India
Authors: Patel Sujata 
Published: January 2021

AbstractThis paper analyzes the work of two Indian sociologists who defined the contours of sociology in India in the immediate post-independence decades, M. N. Srinivas and A. R. Desai. It argues that their scholarship can be linked to sociology’s legacy as anthropology in India and its embeddedness in the episteme of colonial modernity. It contends that Srinivas’s methodology, the field view, attempted to make a break with earlier methods, such as book view. However, his three concepts, that of dominant caste, Sanskritization and Westernization were perceived as civilizational attributes and which had organized social change in India. A. R. Desai, a Marxist historical sociologist, made an incisive critique of capitalist exploitation and elaborated the material conditions that led to peasant and working-class revolts. However, his sociology could not unravel the caste-class linkages that organized the Indian ‘social’ which was embedded in Indian nationalism. This paper suggests that a definitive understanding of modernity emerges in Indian sociology in the late 70s when the feminist, dalit and tribal movements interrogated the material basis of contemporary India’s developmentalism and its capitalist and exploitative character.
A 10-year trend in piglet pre-weaning mortality in breeding herds associated with sow herd size and number of piglets born alive
Authors: Koketsu Yuzo , Iida Ryosuke , Piñeiro Carlos 
Published: January 2021

Abstract
Background
Piglet pre-weaning mortality (PWM) is one of the biggest problems regarding sow performance and piglet welfare. Recently, PWM has increased in some countries, but it is not known if there are similar increases in other countries, nor whether increased PWM is related to either increased numbers of piglets born alive (PBA) or to sow herd size. So, the objectives of the present study were 1) to explore the trend in PWM in Spanish sow herds over a recent 10-year period, along with related measurements such as PBA, stillborn piglets, herd productivity and herd size; and 2) to examine the relationships between PWM and the related measurements.

Methods
Herd-level annual data from 2007 to 2016 for 91 herds in Spain were abstracted from a sow database compiled by a veterinary consultancy firm that asked client producers to mail data files on a regular basis. The database software automatically calculated herd-level PWM (%) as follows: the total number of piglets born alive to a sow completely weaned during a year (TPBA) minus the total number of piglets weaned by the completely weaned sow during the year divided by TPBA × 100. All the statistical analyses were performed by using SAS University Edition. A growth curve model was applied to incorporate correlations for all of the observations arising from the same farm.

Results
Over the 10 years, herd means of PWM (standard deviation) increased from 11.9 (4.1) % to 14.4 (3.2) %, and mean PBA increased by 1.9 pigs. Mean age of piglet death during lactation increased by 3.8 days, and later years were significantly associated with herd size and the number of piglets weaned per sow per year (PSY; P <  0.05). Higher PWM was associated with more PBA, more stillborn piglets and small-to-mid herds (lower than the median size: < 570 sows; P <  0.05). Also, there was a significant interaction between the herd size groups and PBA for PWM (P <  0.05): as PBA increased from 9 to 14 pigs, PWM increased by 9.6% in small-to-mid herds, compared with an increase of only 6.6% in large herds (> 570 sows). Furthermore, as PWM decreased from 18 to 8%, herd productivity measured as PSY increased by 2.2 pigs in large herds, compared with only 0.6 pigs in small-to-mid herds.

Conclusion
Large herds were better than small-to-mid herds at alleviating the association between increased PBA and increased PWM. Also, the relationship between decreased PWM and increased herd productivity was improved more in large herds than in small-to-mid herds.