bluuebunny/crossref_metadata_2025_split huggingface dataset:
Qi Dan Li Xin pill improves chronic heart failure by regulating mTOR/p70S6k-mediated autophagy and inhibiting apoptosis
Authors: Shi Binhao , Huang Yuting , Ni Jingyu , Chen Jingrui , Wei Jing , Gao Hui , Li Lan , Zhou Zhengcan , Wang Yili , Xu Yunsheng , Xu Zongpei , Mao Jingyuan , Fan Guanwei 
Published: April 2020

AbstractMyocardial remodeling represents a key factor in chronic heart failure (CHF) development, and is characterized by chronic death of cardiomyocytes. Cardiac function changes may be attributed to inflammation, apoptosis and autophagy. This study assessed the effects of Qi Dan Li Xin Pill (QD) on heart function, inflammatory factors, autophagy and apoptosis in cardiac remodeling in CHF rats upon myocardial infarction (MI) induction. Male SD rats underwent a sham procedure or left anterior descending coronary artery (LADCA) ligation, causing MI. Twenty-eight days after modeling, the animals were treated daily with QD, valsartan and saline for 4 weeks. Echocardiography after 4 weeks of drug intervention revealed substantially improved left ventricular remodeling and cardiac function following QD treatment. As demonstrated by decreased IL-1β, IL-6 and TNF-α amounts, this treatment also inhibited the apoptotic process and protected the viability of the myocardium. These outcomes may be attributed to enhanced autophagy in cardiomyocytes, which further reduced pro-inflammatory and pro apoptotic effects. This process may be achieved by QD regulation of the mTOR/P70S6K signaling pathway, suggesting that the traditional Chinese medicine Qi Dan Li Xin pill is effective in heart protective treatment, and is worth further investigation.
Larval Geoduck (Panopea generosa) Proteomic Response to Ciliates
Authors: Timmins-Schiffman Emma , Guzmán José M. , Elliott Thompson Rhonda , Vadopalas Brent , Eudeline Benoit , Roberts Steven B. 
Published: April 2020

AbstractThe innate immune response is active in invertebrate larvae from early development. Induction of immune response pathways may occur as part of the natural progression of larval development, but an up-regulation of pathways can also occur in response to a pathogen. Here, we took advantage of a protozoan ciliate infestation of a larval geoduck clam culture in a commercial hatchery to investigate the molecular underpinnings of the innate immune response of the larvae to the pathogen. Larval proteomes were analyzed on days 4–10 post-fertilization; ciliates were present on days 8 and 10 post-fertilization. Through comparisons with larval cultures that did not encounter ciliates, proteins implicated in the response to ciliate presence were identified using mass spectrometry-based proteomics. Ciliate response proteins included many associated with ribosomal synthesis and protein translation, suggesting the importance of protein synthesis during the larval immune response. There was also an increased abundance of proteins typically associated with the stress and immune responses during ciliate exposure, such as heat shock proteins, glutathione metabolism, and the reactive oxygen species response. These findings provide a basic understanding of the bivalve molecular response to a mortality-inducing ciliate and improved characterization of the ontogenetic development of the innate immune response.
Sea-spray regulates sulfate cloud droplet activation over oceans
Authors: Fossum Kirsten N. , Ovadnevaite Jurgita , Ceburnis Darius , Preißler Jana , Snider Jefferson R. , Huang Ru-Jin , Zuend Andreas , O’Dowd Colin 
Published: April 2020

AbstractSulfate aerosols are typically the dominant source of cloud condensation nuclei (CCN) over remote oceans and their abundance is thought to be the dominating factor in determining oceanic cloud brightness. Their activation into cloud droplets depends on dynamics (i.e. vertical updrafts) and competition with other potential CCN sources for the condensing water. We present new experimental results from the remote Southern Ocean illustrating that, for a given updraft, the peak supersaturation reached in cloud, and consequently the number of droplets activated on sulfate nuclei, is strongly but inversely proportional to the concentration of sea-salt activated despite a 10-fold lower abundance. Greater sea-spray nuclei availability mostly suppresses sulfate aerosol activation leading to an overall decrease in cloud droplet concentrations; however, for high vertical updrafts and low sulfate aerosol availability, increased sea-spray can augment cloud droplet concentrations. This newly identified effect where sea-salt nuclei indirectly controls sulfate nuclei activation into cloud droplets could potentially lead to changes in the albedo of marine boundary layer clouds by as much as 30%.
Accurate surgical navigation with real-time tumor tracking in cancer surgery
Authors: Kok Esther N. D. , Eppenga Roeland , Kuhlmann Koert F. D. , Groen Harald C. , van Veen Ruben , van Dieren Jolanda M. , de Wijkerslooth Thomas R. , van Leerdam Monique , Lambregts Doenja M. J. , Heerink Wouter J. , Hoetjes Nikie J. , Ivashchenko Oleksandra , Beets Geerard L. , Aalbers Arend G. J. , Nijkamp Jasper , Ruers Theo J. M. 
Published: April 2020

AbstractIn the past decades, image-guided surgery has evolved rapidly. In procedures with a relatively fixed target area, like neurosurgery and orthopedics, this has led to improved patient outcomes. In cancer surgery, intraoperative guidance could be of great benefit to secure radical resection margins since residual disease is associated with local recurrence and poor survival. However, most tumor lesions are mobile with a constantly changing position. Here, we present an innovative technique for real-time tumor tracking in cancer surgery. In this study, we evaluated the feasibility of real-time tumor tracking during rectal cancer surgery. The application of real-time tumor tracking using an intraoperative navigation system is feasible and safe with a high median target registration accuracy of 3 mm. This technique allows oncological surgeons to obtain real-time accurate information on tumor location, as well as critical anatomical information. This study demonstrates that real-time tumor tracking is feasible and could potentially decrease positive resection margins and improve patient outcome.
Feed gas exchange (startup/shutdown) effects on Pt/C cathode electrocatalysis and surface Pt-oxide behavior in polymer electrolyte fuel cells as revealed using in situ real-time XAFS and high-resolution STEM measurements
Authors: Samjeské Gabor , Kaneko Takuma , Gunji Takao , Higashi Kotaro , Uruga Tomoya , Tada Mizuki , Iwasawa Yasuhiro 
Published: April 2020

Feed gas exchange (startup/shutdown) effects on Pt/C electrocatalysis and surface Pt-oxide behavior in PEFC were investigated by in situ real-time XAFS, synchronized with CV, and high-resolution STEM for the first time.
Was erschwert die Aufdeckung organisierter und ritueller Gewaltstrukturen?
Authors: Schröder Johanna , Behrendt Pia , Nick Susanne , Briken Peer 
Published: April 2020

Zusammenfassung
Ziel der Studie Untersuchung sexuellen Kindesmissbrauchs in organisierten und rituellen Gewaltstrukturen (d. h. vernetzte Täter_innengruppen mit ideologischen Hintergründen).
Methodik Es wurden 33 Berichte von Betroffenen und Zeitzeug_innen mittels qualitativer Inhaltsanalyse ausgewertet. Dabei wurden in Bezug auf die Fragestellung, welche Faktoren die Aufdeckung solcher Strukturen erschweren, induktiv Kategorien gebildet.
Ergebnisse Die Ergebnisse legen nahe, dass verschiedene (Beziehungs-)Aspekte dreier wechselseitig interagierender Personengruppen die Aufdeckung solcher Strukturen erschweren können: Täter_innen, die Betroffenen und andere Personen (z. B. im direkten Umfeld der Betroffenen und in der Gesellschaft).
Schlussfolgerung Um die beschriebenen Systemfaktoren im Sinne einer verbesserten Aufdeckung dieser Gewaltstrukturen positiv beeinflussen zu können, ist eine sachliche Wissensvermittlung an verschiedene Institutionen der Gesellschaft notwendig.
„Man gesteht sich ja heutzutage keine Depression mehr ein, sondern nennt es Burnout“
Authors: Nowikow Julia , Rechenberg Theresia , Schomerus Georg 
Published: April 2020

ZusammenfassungZiel der Studie Identifizierung von Überschneidungen und Differenzen zum Störungsbild Depression, die sich in der Berichterstattung über Burnout zeigen.Methodik Qualitative Inhaltsanalyse von 3 überregionalen Tageszeitungen aus den Jahren 2016 und 2017.Ergebnisse Häufig weist die dargestellte Symptomatik von Burnout Bezüge zu den Leitsymptomen einer Depression auf. Differenzen werden in den dargestellten Ursachen und therapeutischen Maßnahmen sichtbar.Schlussfolgerung In der Berichterstattung erscheint das Phänomen Burnout durch den Arbeitsbezug, die bildliche Qualität des Begriffs und die zahlreichen Offenlegungen prominenter Betroffener nahbarer als eine Depression. Vor- und Nachteile dieses Phänomens werden im Hinblick auf Stigmatisierung diskutiert.
Fast Return to Sports and High Level of Activity after Cementless Oxford Unicompartmental Knee Arthroplasty
Authors: Panzram Benjamin , Mandery Mira , Reiner Tobias , Walker Tilman , Merle Christian , Gotterbarm Tobias 
Published: April 2020

AbstractPhysical activity is essential for overall health. For patients undergoing knee arthroplasty, questions about the implant's suitability for sports arise. The general recommendations for physical activity with knee replacements are often based upon experts' opinions, with a lack of scientific data. This study was performed at an independent high-volume center and aimed to investigate what level of activity patients can achieve and how they perform with a well-functioning cementless unicompartmental knee replacement (UKR). Possible differences in outcome in regards to patients' body mass index (BMI) were also examined. A total of 228 knees treated with cementless Oxford UKR (OUKR) were followed up after a mean of 37.1 months. Tegner's and UCLA (University of California, Los Angeles) scores were obtained to assess the level of physical activity. The Schulthess Clinical Activity Questionnaire was assessed for detailed information on practiced sports, and the SF-36 questionnaire was evaluated to analyze patients' quality of life. The return to activity rate was 92.9%. In total, 64% of the physically active patients had already taken up sports within 3 months after surgery. Mean Tegner's score was at 3.5, and mean UCLA score was at 6.3. High impact sports were not performed very often after surgery. Higher BMI showed a negative correlation with the numbers of sports (rsp = −0.289) as well as Tegner's (rsp = −0.222) and UCLA (rsp = −0.383) scores. The SF-36 scores were comparably good to those in an age-equivalent standard reference group. In conclusion, cementless OUKR allows a fast return to activity with a high level of physical exercise. Patients with increased BMI tend to practice less types of sports with decreased activity scores.
Does Increasing Patient Complexity Have an Effect on Medical Outcomes and Lengths-of-Stay after Total Knee Arthroplasty?
Authors: Anis Hiba K. , Sodhi Nipun , Acuña Alexander J. , Roth Alexander , Vakharia Rushabh , Newman Jared M. , Mufarrih Syed H. , Grossman Eric , Roche Martin W. , Mont Michael A. 
Published: April 2020

AbstractA greater number of medically complex patients with multiple comorbidities are now more readily considered for total knee arthroplasty (TKA). Therefore, the purpose of this study was to determine whether comorbidity burden, measured with the Elixhauser Comorbidity Index (ECI), correlated with 90-day medical complications and longer in-hospital lengths-of-stay (LOS) in TKA patients. The PearlDiver supercomputer was queried for all primary TKA patients in the Medicare Standard Analytic Files from 2005 to 2014 using International Classification of Disease, 9th edition codes. Patients were included based on ECI scores, ranging from 1 to 5. ECI 1 patients served as the control cohort, while ECI 2, 3, 4, and 5 patients were considered study cohorts. Each study cohort was matched based on age and gender to the control cohort, resulting in a total of 715,398 patients included for analysis (ECI 1, n = 144,072; ECI 2, n = 144,072; ECI 3, n = 144,072; ECI 4, n = 144,072; ECI 5, n = 139,110). Logistic regression analyses were performed to compare 90-day medical complications and Welch's t-tests were performed to compare LOS between the cohorts. Patients with higher ECI scores were more likely to develop medical complications and have longer LOS compared with matched patients in the control cohort. Compared with matched ECI 1 patients, patients with ECI scores of 2 (odds ratio [OR]: 1.19, 95% confidence interval [CI]: 1.14–1.24), 3 (OR: 1.27, 95% CI: 1.21–1.32), 4 (OR: 1.32, 95% CI: 1.27–1.38), and 5 (OR: 1.33, 95% CI: 1.27–1.39) were significantly more likely to develop 90-day medical complications. Additionally, the mean LOS of patients in the ECI 2 (2.59 ± 1.49 vs. 2.73 ± 1.52 days), ECI 3 (2.59 ± 1.49 vs. 2.88 ± 1.51 days; p < 0.001), ECI 4 (2.59 ± 1.49 vs. 3.01 ± 1.56 days; p < 0.001), and ECI 5 (2.61 ± 1.49 vs. 3.14 ± 1.61 days; p < 0.001) groups were significantly longer than the mean LOS in the control ECI 1 group. In an increasingly complex patient population, associations between comorbidities and outcomes after TKA procedures can guide providers on how to modify their pre- and postoperative care. These results demonstrate that higher ECI scores are associated with a greater likelihood of 90-day medical complications and longer in-hospital LOS.
Treatment of Concomitant ACL and MCL Injuries: Spontaneous Healing of Complete ACL and MCL Tears
Authors: Razi Mohammad , Soufali Amir Payman , Ziabari Elaheh Ziaei , Dadgostar Haleh , Askari Alireza , Arasteh Peyman 
Published: April 2020

AbstractThe mainstay of treatment for anterior cruciate ligament (ACL) tear is considered to be surgery, especially when associated with medial collateral ligament (MCL) tears. We aimed to evaluate our hypothesis that some patients with concomitant ACL and MCL tears may develop spontaneous healing without surgical intervention. This study was conducted during 2013 to 2017. A total of 707 patient referred with combined ACL and MCL injuries. Patients were divided into three groups according to type of ACL and MCL management as follows: (1) group 1 as those who only had ACL reconstruction without any surgical treatment of MCL; (2) group 2 as those who had ACL reconstruction and MCL surgery (reconstruction, reefing, or both); (3) group 3 as those who showed spontaneous healing of ACL and MCL. Overall, 206 and 129 patients entered groups 1 and 2, respectively. Overall, 15 patients showed spontaneous healing of ACL and entered group 3. Skiing and soccer were the most common causes of injury within the third group, followed by traffic accidents (35.7%, 35.7% and 21.4%, respectively). All these were noncontact injuries within this groups. In group 3 only three patients had concomitant meniscal injury. Mean healing time for patient with spontaneous healing was 8.66 ± 3.41 months. All patients showed ACL tears at the proximal part of its attachment. During follow-up, all pivot shift, Lachman and MCL tests were either negative or one plus. All these individuals returned to previous physical activity. Among the total number of patients with skiing injuries presenting with concomitant ACL/MCL injuries (27 patients), five patients (18.5%) showed spontaneous healing. Valgus and external rotation injuries with dominancy of valgus force, apart from a MCL tear, may lead to proximal tear of ACL as well, and the inflammation from the torn MCL can potentiate and stimulate the healing process of ACL; thus, patient with this mechanism of injury is better followed before surgical intervention is planned as spontaneous healing may occur.
Initial data and first evolutions of dust clouds in bimetric relativity
Authors: Kocic Mikica , Torsello Francesco , Högås Marcus , Mörtsell Edvard 
Published: April 2020

AbstractWe present a method for solving the constraint equations in the Hassan–Rosen bimetric theory to determine the initial data for the gravitational collapse of spherically symmetric dust. The setup leads to equations similar to those for a polytropic fluid in general relativity, here called Lane–Emden-like equations. Using a numerical code which solves the evolution equations in the standard 3 + 1 form, we also obtain a short-term development of the initial data for these bimetric spherical clouds. The evolution highlights some important features of the bimetric theory such as the interwoven and oscillating null cones representing the essential nonbidiagonality in the dynamics of the two metrics. The simulations are in the strong-field regime and show that, at least at an early stage, if the bimetric initial data are close to those for general relativity, the bimetric evolution stays close to the evolution in general relativity as well, and with no instabilities, albeit with small oscillations in the metric fields. In addition, we determine initial data and first evolution for vacuum bimetric spherically symmetric nonstationary solutions, providing generic counterexamples to a statement analog to Jebsen–Birkhoff theorem in bimetric relativity.
Vibrationally resolved electron impact electronic excitation of BeH
Authors: Darby-Lewis D , Tennyson J , Yurchenko S N , Lawson K D 
Published: April 2020

Abstract
Beryllium is being adopted for plasma facing walls in fusion reactors. This has led to the observation of emissions from the A 2Π state of beryllium hydride. Use of these emissions to monitor Be erosion requires electron impact excitation rates. Cross sections for electron impact vibrational excitation within the X 2Σ+ state and vibrationally resolved electronic excitation to the A 2Π state are reported for BeH, BeD and BeT. Electron collisions are studied at a range of internuclear separations using the UK molecular R-matrix (UKRmol+) codes. Electronic excitation is studied both within the Franck–Condon approximation and by explicit averaging of the T-matrix elements. It is found that (a) inclusion of the effect of higher partial waves using the Born approximation leads to significant increases in the cross sections and (b) the Franck–Condon approximation underestimates the importance of collisions for which the vibrational state changes during electronic excitation.
Pushing Cherenkov PET with BGO via coincidence time resolution classification and correction
Authors: Kratochwil Nicolaus , Gundacker Stefan , Lecoq Paul , Auffray Etiennette 
Published: April 2020

Abstract
Bismuth germanate (BGO) shows good properties for positron emission tomography (PET) applications, but was substituted by the development of faster crystals like lutetium oxyorthosilicate (LSO) for time-of-flight PET (TOF-PET). Recent improvements in silicon photomultipliers (SiPMs) and fast readout electronics make it possible to access the Cherenkov photon signal produced upon 511 keV interaction, which makes BGO a cost-effective candidate for TOF-PET.
Tails in the time-delay distribution, however, remain a challenge. These are mainly caused by the high statistical fluctuation on the Cherenkov photons detected. To select fast events with a high detected Cherenkov photon number, the signal rise time of the SiPM was used for discrimination. The charge, time delay and signal rise time was measured for two different lengths of BGO crystals coupled to FBK NUV-HD SiPMs and high frequency readout in a coincidence time resolution setup. The recorded events were divided into 5 × 5 categories based on the signal rise time, and time resolutions of 200 ± 3 ps for 2 × 2 × 20 mm3 and 117 ± 3 ps for 2 × 2 × 3 mm3 were measured for the fastest 20% of the events (4% in coincidence). These good timing events can provide additional information for the image reconstruction in order to increase the SNR significantly, without spoiling the detector sensitivity. Putting all photopeak events together and correcting for the time bias introduced by different numbers of Cherenkov photons detected, time resolutions of 259 ± 3 ps for 20 mm long and 151 ± 3 ps for 3 mm long crystals were measured. For a small fraction of events sub-100 ps coincidence time resolution with BGO was reached for a 3 mm short pixel.
Dynamical properties of a few mass-imbalanced ultra-cold fermions confined in a double-well potential
Authors: Nandy Dillip K , Sowiński Tomasz 
Published: April 2020

Abstract
A comprehensive analysis of the exact unitary dynamics of two-component mass-imbalanced fermions in a one-dimensional double-well potential is accomplished by considering the total number of particles maximum up to six. The simultaneous effect of mass imbalance between the flavors and their mutual interactions on the dynamics is scrutinized through the exact diagonalization. In particular, we investigate the occupation dynamics of such systems being initially prepared in experimentally accessible states in which opposite components occupy opposite wells. Moreover, to capture the role of interactions, we also inspect situations in which initial states contain an opposite-spin pair localized in a chosen well. Finally, to assess the amount of quantum correlations produced during the evolution, we analyze the behavior of the von Neumann entanglement entropy between components.
The effect of microwave irradiation on reduced graphene oxide from coconut shells
Authors: Yanti D R , Hikmah U , Prasetyo A , Hastuti E 
Published: April 2020

Abstract
Reduced graphene oxide has been synthesized by microwave irradiation assisted. The effect of microwave irradiation on its crystal structure and electrical conductivity was investigated. Graphene oxide was synthesized using a modified hummers method then reduced by LAA (L-Ascorbic Acid) as a reducing agent with microwave irradiation assisted. The irradiation time varied by 10, 20, 30, and 40 minutes. The samples characterized by Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy-EDAX (SEMEDAX), X-Ray Diffractometer (XRD), and Inductance Capacitance and Resistance Meters (LCR-Meters).
Pilot-scale production of Boletus colossus culture for promoting the growth of Para rubber trees
Authors: Dechmahitkul W , Khumvongsa K , Mekvichitsaeng P 
Published: April 2020

Abstract

Boletus colossus is an Ectomycorrhiza fungi. It grows on roots of big trees such as Rubber tree, Mango tree and etc. This mushroom grows by using the organic materials released from the roots. The moisture adsorbed on the fungi makes the roots resist the drought better. The mushroom can also turn some insoluble inorganic materials into the form that plants can make use of. This research is to study the production of the starter culture by using low-cost media. The result shows that the fungi can grow best in whey to 9.2 g/L (dry weight) in 10 days. The liquid broth can inhibit the growth of pathogens (Alternaría brasicola, Alternaría pori, and Fusarium solani) on Potato-Dextrose agar. The starter culture can also be produced in a 50L fermenter to the dry weight of 8.1 g/L in 6 days. Loam is the best as solid carrier followed by peat moss. The result in one year shows that the Para rubber trees grow with the fungi that have significantly longer stems, leaves, and roots.