bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tumor Volume Useful Beyond Classic Criteria in Selecting Larynx Cancers For Preservation Therapy
Authors: Sharrett Jonathan M. , Ward Matthew C. , Murray Eric , Scharpf Joseph , Lamarre Eric D. , Prendes Brandon L. , Lorenz Robert R. , Burkey Brian B. , Koyfman Shlomo A. , Woody Neil M. , Greskovich John F. , Adelstein David J. , Geiger Jessica L. , Joshi Nikhil P. 
Published: November 2019

ObjectiveTo investigate the association between tumor volume and locoregional failure (LRF) after concurrent chemoradiation (CCRT) for locally advanced larynx cancer (LC).MethodsThis is a retrospective cohort study from 2009 to 2014 identified from an institutional review board–approved registry. Fifty‐nine of 68 patients with locally advanced larynx cancer treated with definitive CCRT who had available imaging for review were identified. The main endpoint to be assessed was the association between gross tumor volumes (GTV; T = total, P = primary, N = nodal) and LRF. Receiver operative characteristic (ROC) curves were used to investigate diagnostic accuracy.ResultsTwenty LRFs were observed, resulting in a 2‐year LRF rate of 39% (95% CI, 23–52%). On UVA, the GTV‐T (P = .01), GTV‐P (P = .05), and GTV‐N (P = .04) were statistically significant predictors of LRF. Furthermore, age, smoking status, N‐stage, larynx subsite, and tracheostomy/feeding tube dependence were potentially associated with LRF (P < .3), whereas T‐stage (T3–4 vs. T2) was not (HR 1.05, 95% CI, 0.38–2.91, P = .92). In the multivariable model, GTV‐P (HR 1.022, 95% CI, 0.999–1.046, P = .07) and GTV‐N (HR 1.053, 95% CI, 1.0004–1.108, P = .05) were the two most impactful covariates on the model's R2. ROC analysis suggested an optimal cut point of 12 cc in the GTV‐T. The 2‐year LRF for GTV‐T > 12 cc was 64.2% and ≤ 12 cc was 16.4%, P = .006.ConclusionGTV is associated with LRF after definitive CCRT for LC. Patients with bulky primary and/or nodal tumors may be better served with upfront surgical resection regardless of T‐stage. Further investigation into the safety of larynx preservation for low‐volume T4 tumors can be considered.Level of Evidence4 Laryngoscope, 130:2372–2377, 2020
Corrosion behavior of GO‐reinforced TC4 nanocomposites manufactured by selective laser melting
Authors: Liu Xin , Wu Meiping , Lu Peipei , Ye Xiu , Miao Xiaojin 
Published: November 2019

AbstractTo improve the corrosion resistance of Ti–6Al–4V (TC4) matrix, the influence on the corrosion behavior, microhardness, and microstructure of graphene oxide (GO)‐reinforced TC4 nanocomposites manufactured by selective laser melting was systematically investigated in this study. Microhardness tester, profilometer, X‐ray diffractometer, scanning electron microscopy, and electrochemical workstation were used to characterize the association between microhardness, pore microstructures, hard phases, and corrosion resistance of GO/TC4 nanocomposites. It can be observed that the incorporation of GO promotes the in situ formation of hard phases, such as TiC, TiO2, Al2O3, and so forth, and it also changes the microstructure of the matrix as well as increases its porosity. Nevertheless, GO/TC4 nanocomposites perform the best corrosion resistance when the mixing content of GO is 0.5 wt%, and its microhardness is greatly improved with the addition of GO. All experimental results suggest the efficacy of added GO.
All Sugar Based Cellulose Derivatives Synthesized by Azide–Alkyne Click Chemistry
Authors: Koschella Andreas , Chien Chih‐Ying , Iwata Tadahisa , Thonhofer Martin S. , Wrodnigg Tanja M. , Heinze Thomas 
Published: November 2019

AbstractCellulose is functionalized with different monosaccharides by the azide–alkyne click chemistry approach. Either azide or alkyne moieties are attached to the cellulose backbone and allowed to react with sugar moieties bearing the opposite clickable groups. Between 16% and 100% of the reactive sites at the polymer can be functionalized with sugar molecules and a clear correlation between steric demand and DSSugar is observed. The polymers remain soluble in aprotic dipolar media like dimethyl sulfoxide. Products with a sufficient hydrophilicity dissolve in water as well. FTIR‐ and NMR spectroscopy reveal the triazole formation and indicate an incomplete conversion of the reactive sites as usually observed in the field of click chemistry with polymers.
The aryl hydrocarbon receptor (AhR) as a breast cancer drug target
Authors: Baker Jennifer R. , Sakoff Jennette A. , McCluskey Adam 
Published: November 2019

AbstractBreast cancer is the most common cancer in women, with more than 1.7 million diagnoses worldwide per annum. Metastatic breast cancer remains incurable, and the presence of triple‐negative phenotypes makes targeted treatment impossible. The aryl hydrocarbon receptor (AhR), most commonly associated with the metabolism of xenobiotic ligands, has emerged as a promising biological target for the treatment of this deadly disease. Ligands for the AhR can be classed as exogenous or endogenous and may have agonistic or antagonistic activity. It has been well reported that agonistic ligands may have potent and selective growth inhibition activity in a number of oncogenic cell lines, and one (aminoflavone) has progressed to phase I clinical trials for breast cancer sufferers. In this study, we examine the current state of the literature in this area and elucidate the promising advances that are being made in hijacking the cytosolic‐to‐nuclear pathway of the AhR for the possible future treatment of breast cancer.
Investigation of the Effective Parameters on Preparation of the Gelled IRFNA
Authors: Saberimoghaddam Ali , Emamifard Zahra , Mahdi Bahri Rasht Abadi Mohammad , Meyghani Naeem 
Published: November 2019

AbstractIn the present work, the gelled IRFNA oxidizer was prepared and its quality was analyzed using several methods. Obtained results showed that fumed silica with mean particle size of 12 nm was appropriate gelling agent for preparing the gelled IRFNA. Moreover, mixing time of 30 min was sufficient for preparing the gel. Considering the effect of temperature (between −5 °C and 35
) on the quality of the prepared gel showed that preparing the gel was feasible in the temperature range between −4 °C and 35 °C, but temperature range between 25 °C and 35 °C was more appropriate than the total range. Time needed for developing the gel network was 24 h in which the gel viscosity increased up to 30 % compared to the viscosity of the gel immediately after its preparation. The quality analysis showed a good stability of the gel in temperature range between (−52
) and (+64
). The prepared gel retained its desirable rheological properties for at least 6 months. Mechanical stability test in acceleration of 500 g for 30 mins showed that the prepared gel had suitable mechanical stability. In addition, the prepared gel showed desirable rheological properties such as shear thinning, thixotropic and hysteresis. The viscometry results were in a good agreement with power law model. Flow behavior index (n) was increased from 0.2 to 0.3 by decreasing the gellant percentage from 4.5 to 3 % which show decreasing the shear thinning behavior of gel due to decrease in the gel gellant percentage.
Cross‐docking benchmark for automated pose and ranking prediction of ligand binding
Authors: Wierbowski Shayne D. , Wingert Bentley M. , Zheng Jim , Camacho Carlos J. 
Published: November 2019

AbstractSignificant efforts have been devoted in the last decade to improving molecular docking techniques to predict both accurate binding poses and ranking affinities. Some shortcomings in the field are the limited number of standard methods for measuring docking success and the availability of widely accepted standard data sets for use as benchmarks in comparing different docking algorithms throughout the field. In order to address these issues, we have created a Cross‐Docking Benchmark server. The server is a versatile cross‐docking data set containing 4,399 protein‐ligand complexes across 95 protein targets intended to serve as benchmark set and gold standard for state‐of‐the‐art pose and ranking prediction in easy, medium, hard, or very hard docking targets. The benchmark along with a customizable cross‐docking data set generation tool is available at http://disco.csb.pitt.edu. We further demonstrate the potential uses of the server in questions outside of basic benchmarking such as the selection of the ideal docking reference structure.
Automaticity and Control: How Do Executive Functions and Reading Fluency Interact in Predicting Reading Comprehension?
Authors: Kieffer Michael J. , Christodoulou Joanna A. 
Published: November 2019

AbstractThe authors investigated the roles of reading fluency in mediating and moderating the relation between executive functions and reading comprehension. Linguistically diverse students (n = 106) were assessed on multiple measures of reading fluency at the passage and word levels, reading comprehension, and executive functions in grade 7 and again in grade 8. Path analyses using factor scores indicated that executive functions made indirect (mediated) contributions to reading comprehension via reading fluency, controlling for oral vocabulary and processing speed in both grades. Mediation was partial, with a statistically significant direct contribution of executive functions to reading comprehension remaining. Interaction analyses indicated that executive functions also statistically significantly interacted with reading fluency in predicting reading comprehension in both grades. Contrary to theoretical predictions, these interactions were positive, with executive functions predicting reading comprehension more strongly for students with higher reading fluency. Findings indicate that executive functions are implicated in reading fluency and that the contributions of executive functions and reading fluency to reading comprehension may be multiplicative rather than additive or compensatory.
RCM vs Oxacycloisomerization through Divergent Reactivity of Dienyl‐ or Ynenylcycloalkanols using Grubbs Catalyst: an Access to Carbobicycles and Fused Bicyclic Dihydrofurans
Authors: Taleb Assya , Lahrech Mokhtar , Hacini Salih , Thibonnet Jerome , Parrain Jean‐Luc 
Published: November 2019

AbstractStarting from simple cyclic 1,3‐ketoesters, a three‐steps sequence including allylic or propargylic allylation, 1,2‐addition reaction of functional Grignard reagent and alkylidene ruthenium‐catalyzed cyclization yields to carbobicycles and/or bicyclic dihydrofurans depending on the nature of the insaturation (diene or enyne). If the classical ene‐ene ring closing metathesis is observed with dienyl substituents, similar enynes led to enyne ring closing metathesis or oxacycloisomerization products depending on the chain length. In the case of ene‐yne systems with appropriate longer carbon chains, under the same conditions, metathesis reations give access to bicyclic dihydrofurans through oxacycloisomerization, demonstrating that it is possible to orient the activity of the Grubbs reagent.
Computational Design and Electropolymerization of Molecularly Imprinted Poly(p‐Aminobenzoic‐Acid‐Co–Dapsone) Using Multivariate Optimization for Tetradifon Residue Analysis
Authors: Ganjeizadeh Rohani Fatemeh , Mohadesi Alireza , Ansari Mehdi 
Published: November 2019

AbstractIn this study, tetradifon as a non‐electroactive pesticide was measured by a new gold electrode modified with electropolymerized molecularly imprinted poly(para aminobenzoic acid‐co‐4,4‐diaminodiphenyl sulfone) (P‐pABA‐co‐DDS). The best available monomer was selected based on computational design and then the polymer was developed in optimized condition. Screening of various factors was performed by Plackett–Burman design (PBD) and central composite design (CCD) was utilized to select optimized condition. Under the optimized condition, calibration curve of tetradifon on MIP/gold electrode was constructed with a linear range of 0.05‐ 2.50 μM. The limit of detection (LOD) and limit of quantification (LOQ) was found to be 0.014 and 0.047 μM, respectively. The developed method showed good stability, repeatability, and reproducibility, sensitivity and selectivity for tetradifon. The developed method was applied to determine tetradifon in real water samples.
Adsorption of Lead and Arsenic Ions from Aqueous Solution by Activated Carbon Prepared from Tamarix Leaves
Authors: Koohzad Elnaz , Jafari Dariush , Esmaeili Hossein 
Published: November 2019

AbstractLead and arsenic are regarded as the significant heavy metal ions which have a great contribution in the pollution of industrial wastewaters. In this research, the adsorption of Pb (II) and As (III) ions from the aqueous solution was studied using activated carbon prepared from Tamarix leaves as a new adsorbent. The adsorbent was characterized by Brunauer, Emmett, and Teller (BET), X‐ray fluorescence spectrometer (XRF), scanning electron microscope (SEM), energy dispersive X‐ray and mapping (EDX/Map), X‐ray diffraction (XRD), and Raman techniques. Batch experiments were designed to investigate the significance of adsorption parameters including pH, adsorbent dosage, time, temperature, and initial concentration on Pb and As ions removal efficiencies. The experiments indicated that the highest adsorption efficiencies were 97.86% for lead and 96.18% for arsenic ions in pH values of 6 for Pb and 7 for As, adsorbent dosage of 3 g/L and initial concentration of 10 mg/L for both of them, and contact time of 60 min and 40 min for Pb and As ions, respectively. Additionally, the results of adsorption kinetics showed that the pseudo second‐order model was more effective for the description of adsorption mechanism of both metals compared to the pseudo first‐order model. The equilibrium behavior of arsenic and lead ions were described well by Langmuir and Freundlich models, respectively. In addition, thermodynamic studies showed that the current adsorption processes were exothermic and spontaneous. Based on the results, the prepared adsorbent can be considered as a good adsorbent for the removal of Pb and As ions from aqueous solutions.
A Facile Synthesis of Green‐Blue Carbon Dots from Artocarpus lakoocha Seeds and Their Application for the Detection of Iron (III) in Biological Fluids and Cellular Imaging
Authors: Yadav Pradeep Kumar , Singh Vikas Kumar , Kumar Chandan , Chandra Subhash , Jit Satyabrata , Singh Sushil Kumar , Talat Mahe , Hasan Syed Hadi 
Published: November 2019

AbstractHerein, a facile, green and eco‐friendly approach has been applied for the synthesis of fluorescent green‐blue carbon dots (GB‐CDs) through the one‐pot hydrothermal treatment of Artocarpus lakoocha seeds for the first time and entirely characterized via a variety of instrumental techniques like fluorescent spectroscopy, Transmission Electron Microscopy (TEM), X‐Ray Photoelectron Spectra (XPS), X‐Ray diffraction (XRD) and Fourier Transform Infra‐red (FTIR) analysis. The as‐prepared GB‐CDs displayed high fluorescent quantum yield (QY) up to 38.5% and high photostability based on which GB‐CDs were successfully applied as a sensitive nanoprobe for the detection of Fe3+ ion. The sensing of Fe3+ shows a linear range from 2 to 6 μM and the limit of detection was found to be 0.62 μM. The sensing of Fe3+ was further investigated in the bona fide sample like river water and human blood serum. In addition, to explore the potential application, MTT assay was carried out on SH‐SY5Y neuroblastoma cells. The results showed negligible cytotoxicity as well as high cell viability, which revealed that GB‐CDs could be utilized as a fluorescent probe in living cells.
Preparation of ZIF‐8/natural Plant Fiber Composites via Biomimetic Mineralization for Highly Efficient Removal of Formaldehyde
Authors: Ren Lipei , Xiao Xingfang , Chen Yali , Yu Yan , Zhang Qian , Liu Ruina , Xu Weilin 
Published: November 2019

AbstractNovel composites containing zeolitic imidazolate framework‐8 (ZIF‐8) nanocrystals and natural plant fibers (Juncus effusus (JE) fibers) are successfully synthesized. ZIF‐8 nanocrystals are coated onto hydrophilic JE fibers (H‐JE fibers) via biomimetic mineralization after only several seconds at room temperature (25 °C). The ZIF‐8/H‐JE fiber composite (stirring) and ZIF‐8‐BSA/H‐JE fiber composite (biomimetic mineralization) composite materials have excellent formaldehyde (HCHO) removal properties. ZIF‐8‐BSA/H‐JE fiber composites, in particular, are highly efficient HCHO adsorbents. Up to 99.79% HCHO removal at a high concentration (100 mg/m3) can be achieved within 90 min, and 100% removal can be achieved at a low concentration (10 mg/m3) within 17 min. This study provides an effective strategy for developing natural‐plant‐fiber‐based composite materials for environmental protection.
Recent Advances and Prospects of Organic Reactions “On Water”
Authors: Harry Nissy Ann , Radhika Sankaran , Neetha Mohan , Anilkumar Gopinathan 
Published: November 2019

AbstractOrganic reactions “On water” is a rapidly developing area over the past few years. Many important classes of reactions like cross‐coupling reactions, pericyclic reactions, C−H activations etc. were performed on water and have shown tremendous increase in the reaction rates due to the potential hydrogen bonding capacity of water. This review focuses on the recent trends and developments in the field of on water reactions applied to organic synthesis and covers literature from 2016–2019.
Ruthenium‐Catalyzed Hydrogenative Depolymerization of End‐of‐Life Poly(bisphenol A carbonate)
Authors: Alberti Christoph , Eckelt Sarah , Enthaler Stephan 
Published: November 2019

AbstractThe conversion of end‐of‐life products to useful chemicals (waste‐to‐chemicals) can afford a resource‐efficient economy. In this context, the depolymerization of end‐of‐life polymers to yield low molecular weight chemicals can be an interesting target. Based on that, the selective depolymerization of end‐of‐life poly(bisphenol A carbonate) via hydrogenation was studied. Applying hydrogen and a ruthenium(II) complex as catalyst (Milstein Catalyst) end‐of‐life poly(bisphenol A carbonate) was hydrogenated to bisphenol A and methanol. The bisphenol A can be reused for the production of fresh polycarbonates; therefore a recycling is possible. On the other hand methanol can be used as hydrogen carrier and can be subjected to the hydrogen economy.
Degradation Studies of Single Cell and Short Stack for High Temperature Proton Exchange Membrane Fuel Cells Based on PBI/H3PO4 Membrane
Authors: Sun Xuejing , Li Yinhua , Qi Fulai , Jing Fenning , Sun Hai , Sun Gongquan 
Published: November 2019

AbstractDurability is a premise of extensive application for high‐temperature proton exchange membrane fuel cells (HT‐PEMFCs) based on H3PO4 doped polybenzimidazole membrane, but is far unsatisfactory. In this work, using our home‐made electrodes, a single cell with a start‐stop operation for 1900 h and a short stack with a continuous operation for 1344 h are separately conducted at 0.2 A cm−2 with hydrogen‐air feed. After 1900 h operation, an average degradation rate of 59.5 μV h−1 is obtained. Combined scanning electron microscope with energy dispersive spectrometer, transmission electron microscope, and electrochemical methods, the start‐stop operation cause more serious H3PO4 loss, cobalt element leaching, and platinum particles agglomeration, which produces a decreased ion conductivity and a big active polarization loss. In short stack test, we find electrode consistency is more important. An inferior cell enables a rapid failure due to almost complete acid loss in the membrane. The bigger polarization loss and more joule heat at the inferior electrode from a lower ionic and electrical conductivity further make acid loss aggravated, and it is a vicious circle. Despite a big gaps with life requirement, we believe our work will give a guidance for the design of high stable HT‐PEMFCs.
Singlet Oxygen Formation during the Oxygen Reduction Reaction in DMSO LiTFSI on Lithium Air Battery Carbon Electrodes
Authors: Córdoba Daniel , Rodríguez Hernán B. , Calvo Ernesto J. 
Published: November 2019

AbstractFormation of singlet oxygen,1O2, during the O2 electroreduction reaction (ORR) on carbon electrode in Lithium bis‐(tri‐fluoromethylsulfonyl)imide (LiTFSI) dimethyl sulfoxide (DMSO) electrolyte has been detected “in‐operando” by fluorescence quenching of 9,10‐dimethylanthracene, DMA. Furthermore, the formation of 1O2 during ORR requires Li+ ions, while in the presence of the efficient physical 1O2 quencher, sodium azide, DMA fluorescence quenching is negligible. Addition of Li+ ions to superoxide solution in DMSO formed by ORR enhances DMA quenching, which is a proof that 1O2 results from superoxide bimolecular disproportionation.
Loss of Vimentin Enhances Cell Motility through Small Confining Spaces
Authors: Patteson Alison E. , Pogoda Katarzyna , Byfield Fitzroy J. , Mandal Kalpana , Ostrowska‐Podhorodecka Zofia , Charrier Elisabeth E. , Galie Peter A. , Deptuła Piotr , Bucki Robert , McCulloch Christopher A. , Janmey Paul A. 
Published: November 2019

AbstractThe migration of cells through constricting spaces or along fibrous tracks in tissues is important for many biological processes and depends on the mechanical properties of a cytoskeleton made up of three different filaments: F‐actin, microtubules, and intermediate filaments. The signaling pathways and cytoskeletal structures that control cell motility on 2D are often very different from those that control motility in 3D. Previous studies have shown that intermediate filaments can promote actin‐driven protrusions at the cell edge, but have little effect on overall motility of cells on flat surfaces. They are however important for cells to maintain resistance to repeated compressive stresses that are expected to occur in vivo. Using mouse embryonic fibroblasts derived from wild‐type and vimentin‐null mice, it is found that loss of vimentin increases motility in 3D microchannels even though on flat surfaces it has the opposite effect. Atomic force microscopy and traction force microscopy experiments reveal that vimentin enhances perinuclear cell stiffness while maintaining the same level of acto‐myosin contractility in cells. A minimal model in which a perinuclear vimentin cage constricts along with the nucleus during motility through confining spaces, providing mechanical resistance against large strains that could damage the structural integrity of cells, is proposed.