bluuebunny/crossref_metadata_2025_split huggingface dataset:
Irrigation Water Demand Sensitivity to Climate Variability Across the Contiguous United States
Authors: Nie Wanshu , Zaitchik Benjamin F. , Rodell Matthew , Kumar Sujay V. , Arsenault Kristi R. , Badr Hamada S. 
Published: December 2020

AbstractClimate variability is an important driver of irrigation water use in many regions. Efforts to anticipate climate change impacts on future water availability can benefit from understanding how irrigation water demand has responded to these drivers to date. Here we apply satellite‐derived data, meteorological reanalysis, an advanced land surface model, and available state‐level reports to quantify irrigation demand sensitivities to temperature and precipitation across the Contiguous United States, for the period of 2002–2017. As expected, strong negative correlations are found between precipitation and irrigation withdrawals, both simulated and reported. Temperature sensitivities, however, vary by region and season, as do the interactive effects of temperature and precipitation on irrigation. Climate‐induced irrigation variability is largest in transitional climate zones. These transitional zones are generally separate from the regions where rates of irrigation withdrawals are greatest, such that climate‐induced variability in irrigation demand represents a water resource consideration that is distinct from chronic overpumping.
Stress-related memories disrupt sociability and associated patterning of hippocampal activity: a role of hilar oxytocin receptor-positive interneurons
Authors: Meyer Mariah A. A. , Anstötz Max , Ren Lynn Y. , Fiske Michael P. , Guedea Anita L. , Grayson Viktoriya S. , Schroth Samantha L. , Cicvaric Ana , Nishimori Katsuhiko , Maccaferri Gianmaria , Radulovic Jelena 
Published: December 2020

AbstractIn susceptible individuals, memories of stressful experiences can give rise to debilitating socio-affective symptoms. This occurs even when the ability to retrieve such memories is limited, as seen in patients suffering from traumatic amnesia. We therefore hypothesized that the encoding, rather than retrieval, mechanisms of stress-related memories underlie their impact on social and emotional behavior. To test this hypothesis, we used combinations of stress-enhanced and state-dependent fear conditioning, which engage different encoding mechanisms for the formation of stress-related memories. We found that the encoding of stress-enhanced state-dependent memories robustly and sex specifically impairs sociability in male mice and disrupts the asymmetry of dentate gyrus (DG)/CA3 activity accompanying social interactions. These deficits were restored by chemogenetic inactivation of oxytocin receptor-positive interneurons localized in the hilus (Oxtr-HI), and by inactivation of dorsohippocampal efferents to the caudal lateral septum. Together, our data suggest that disrupted patterning of dorsohippocampal DG/CA3 activity underlies stress-induced sociability deficits, and that Oxtr-HI can be a cellular target for improving these deficits.
TAF1A and ZBTB41 serve as novel key genes in cervical cancer identified by integrated approaches
Authors: Wang Mingyuan , Liao Jingnan , Wang Jinjin , Qi Mingming , Wang Kangkai , Wu Wei 
Published: December 2020

AbstractCervical cancer (CC) is the second most common cancer and the leading cause of cancer mortality in women. Numerous studies have found that the development of CC was associated with multiple genes. However, the mechanisms on gene level are enigmatic, hindering the understanding of its functional roles. This study sought to identify prognostic biomarkers of CC, and explore their biological functions. Here we conducted an integrated analysis to screen potential vital genes. Candidate genes were further tested by experiments in clinical specimens and cancer cell line. Then, molecular modeling was used to predict the three-dimensional structure of candidate genes’ proteins, and the interaction pattern was analyzed by docking simulation technique. Among the potential genes identified, we found that TAF1A and ZBTB41 were highly correlated. Furthermore, there was a definite interaction between the proteins of TAF1A and ZBTB41, which was affected by the activity of the p53 signaling pathway. In conclusion, our findings identified TAF1A and ZBTB41 could serve as biomarkers of CC. We confirmed their biological function and deciphered their interaction for the first time, which may be helpful for developing further researches.
RNA-binding protein SORBS2 suppresses clear cell renal cell carcinoma metastasis by enhancing MTUS1 mRNA stability
Authors: Lv Qi , Dong Fan , Zhou Yong , Cai Zhiping , Wang Gangmin 
Published: December 2020

AbstractRNA-binding proteins (RBPs) predominantly contribute to abnormal posttranscriptional gene modulation and disease progression in cancer. Sorbin and SH3 domain-containing 2 (SORBS2), an RBP, has been reported to be a potent tumor suppressor in several cancer types. Through integrative analysis of clinical specimens, we disclosed that the expression level of SORBS2 was saliently decreased in metastatic tissues and positively correlated with overall survival. We observed that overexpression of SORBS2 brought about decreased metastatic capacity in ccRCC cell lines. Transcriptome-wide analysis revealed that SORBS2 notably increased microtubule-associated tumor-suppressor 1 gene (MTUS1) expression. In-depth mechanistic exploring discovered that the Cys2-His2 zinc finger (C2H2-ZnF) domain of SORBS2 directly bound to the 3′ untranslated region (3′UTR) of MTUS1 mRNA, which increased MTUS1 mRNA stability. In addition, we identified that MTUS1 regulated microtubule dynamics via promoting KIF2CS192phosphorylation by Aurora B. Together, our research identified SORBS2 as a suppressor of ccRCC metastasis by enhancing MTUS1 mRNA stability, providing a novel understanding of RBPs during ccRCC progression.
FZD5 contributes to TNBC proliferation, DNA damage repair and stemness
Authors: Sun Yu , Wang Zhuo , Na Lei , Dong Dan , Wang Wei , Zhao Chenghai 
Published: December 2020

AbstractChemotherapy currently remains the standard treatment for triple-negative breast cancer (TNBC). However, TNBC frequently develop chemoresistance, which is responsible for cancer recurrence and distal metastasis. Both DNA damage repair and stemness are related to chemoresistance. FZD5, a member in Frizzled family, was identified to be preferentially expressed in TNBC, and associated with unfavorable prognosis. Loss and gain of function studies revealed that FZD5 contributed to TNBC cell G1/S transition, DNA replication, DNA damage repair, survival, and stemness. Mechanistically, transcription factor FOXM1, which promoted BRCA1 and BIRC5 transcription, acted as a downstream effecter of FZD5 signaling. FOXM1 overexpression in FZD5-deficient/low TNBC cells induced FZD5-associated phenotype. Finally, Wnt7B, a specific ligand for FZD5, was shown to be involved in cell proliferation, DNA damage repair, and stemness. Taken together, FZD5 is a novel target for the development of therapeutic strategies to overcome chemoresistance and prevent recurrence in TNBC.
Transparent ferroelectric glass–ceramics for wastewater treatment by piezocatalysis
Authors: Singh Gurpreet , Sharma Moolchand , Vaish Rahul 
Published: December 2020

AbstractIn piezocatalysis the polarization field found in piezoelectric materials enables and enhances catalytic redox reactions. Here, we explore piezocatalytic dye degradation through transparent glass–ceramics containing piezoelectric crystals. 30SiO2–35Li2O–35Nb2O5 (in mol%) glass–ceramics containing varying amounts of LiNbO3 crystallites were fabricated by melt-quenching, followed by heat-treatment at a crystallization temperature of 650 °C for 2, 3 and 6 hours. During piezocatalysis, the 2 hour heat-treated sample showed up to 90% degradation of methylene blue dye within 150 min of ultrasonication, with no significant change in performance after three piezocatalysis cycles. This sample showed promising activity for degrading cationic and neutral dyes, and is optically transparent. This work demonstrates that transparent ferroelectric glass–ceramics are promising for water-cleaning applications by piezocatalysis.
Improved robust H∞ exponential mean square stabilization for uncertain Markov jump delay systems based on memory‐state feedback control
Authors: Wang Jie , Zhuang Guangming , Xia Jianwei , Zhang Huasheng , Sun Wei 
Published: December 2020

AbstractThis paper investigates the problem of robust exponential mean square stabilisation for uncertain Markov jump systems with time‐varying and mode‐dependent delays based on memory‐state feedback control. Attention is focused on the design of memory‐state feedback controller for uncertain Markov jump systems with time‐varying and mode‐dependent delays such that the closed‐loop uncertain Markov jump systems satisfies robust exponential mean square stability. The improved conditions for the solvability of the memory‐state feedback control problem are obtained via designing mode‐dependent and delay‐dependent L‐K functional. The desired memory‐state feedback controller is given by using linear matrix inequalities. Two simulation examples including a numerical example and a practical example of the industrial non‐isothermal continuous stirred tank reactor are used to demonstrate the effectiveness and usefulness of the delayed feedback control technique that this paper proposes.
Prefrontal haemodynamics based classification of inter‐individual working memory difference
Authors: De A. 
Published: December 2020

This Letter illustrates prefrontal haemodynamics as a neurovascular basis of inter‐personal working memory differences. A functional near‐infrared spectroscopy with sampling frequency ∼2 Hz is used to record the blood oxyhaemoglobin and deoxyhaemoglobin signals from 19 subjects engaged in working memory task of encoding and retrieval of ten symbol‐meaning association learning. The individual difference in working memory performance is classified by supervised learning‐based linear discriminant analysis and ensemble classifiers. Prior to the classification approach, individual performance is labelled as high, moderate and low on the basis of the performance index. The spontaneous haemodynamic activity and task‐evoked responses are marked as background and foreground signals, respectively, which are scaled by means of stream‐independent and stream‐dependent models. The classifiers' performance shows that the stream‐dependent model‐based feature construction‐classification improves classification accuracy to a major extent compared to the stream‐independent model and no gain model. To understand the neurovascular basis of the inter‐individual performance difference, diffused voxel plots are constructed. The voxel plots showed that concurrent activation of orbitofrontal and dorsolateral prefrontal cortex could have a possible association with persons' higher working memory performance.
Dielectric behaviours of bio‐derived epoxy resins from cashew nutshell liquid
Authors: Mu Mulan , Vaughan Alun 
Published: December 2020

AbstractIn this study, four commercially available bio‐derived epoxy systems (extracted from cashew nutshell liquid) were prepared and characterised. The glass transition temperature (T
g), dielectric spectroscopy, DC conductivity and breakdown properties of these epoxy resins were studied. Differential scanning calorimetry (DSC) demonstrated that the T
g of the investigated systems ranged from 67 to 122°C. The DC conductivity was very low (<10−16 S cm−1) and comparable to the conventional dielectrics at room temperature (RT). However, all systems showed a strong temperature dependence of the electrical conductivity and exhibited sharp increase around their respective T
g. Arrhenius analysis led to activation energy, E
a, values around 1 eV; higher E
a values were observed in systems with a lower T
g. Dielectric spectroscopy revealed a flat and low response at temperature below T
g. However, both the real and imaginary permittivity increased with decreasing frequency at mid to low frequencies as the temperatures approached T
g. The variations of AC breakdown strength of all samples were not statistically significant, but the DC breakdown strength of sample 2503A + 2002B was higher than the others, which might be due to reduced charge transport in this system. The results indicate that novel bio‐derived epoxy systems from renewable sources are potential alternatives for traditional petroleum‐based epoxy systems in certain insulation applications.
Blutzuckerselbstmessung – wie kann ein korrekter Wert erzielt werden?
Authors: Baumstark Annette , Jendrike Nina 
Published: December 2020

ZUSAMMENFASSUNGDie Blutzuckerselbstmessung ist seit vielen Jahren ein wichtiger Bestandteil der Diabetestherapie. Die gemessenen Werte werden als Grundlage für Therapieentscheidungen herangezogen und sollten daher möglichst korrekt sein. In messtechnischer Hinsicht bedeutet dies, dass die eingesetzten Blutzuckermesssysteme eine hohe Genauigkeit benötigen. Anforderungen an die Genauigkeit sind in der Norm EN ISO 15197:2015 festgelegt. Abgesehen von der Qualität ist bei der Auswahl eines Blutzuckermesssystems auch die Berücksichtigung von möglichen Interferenten, die im Blut eines Patienten vorliegen können (z. B. bestimmte Medikamente) notwendig. Eine weitere wichtige Voraussetzung, um genaue Messwerte zu erzielen, ist die richtige Handhabung des Messsystems und die korrekte Durchführung der Messung.
Diagnostik des Gestationsdiabetes mellitus in der Praxis
Authors: Heinemann Lutz , Nagel-Reuper Christine , Adamczewski Heinke , Freckmann Guido 
Published: December 2020

ZUSAMMENFASSUNGDie Zahl der Frauen, die an Gestationsdiabetes mellitus (GDM) erkranken, steigt in den letzten Jahren begünstigt durch ein höheres Alter und einen veränderten Lebensstil der Schwangeren beträchtlich an. Um akute sowie Langzeitfolgen für Mutter und Kind auf ein Minimum zu reduzieren, gilt es den GDM frühzeitig zu erkennen und entsprechend zu behandeln. Bereits in der Frühschwangerschaft (vor der 24. SSW) kann mittels einer Nüchtern-Glukosemessung oder durch die Messung des HbA1c-Wertes auf das Vorliegen eines GDM beziehungsweise eines bisher unerkannten Diabetes mellitus hin untersucht werden. Ab der 24. SSW muss nach der deutschen Mutterschaftsrichtlinie von 2012 zudem jeder Schwangeren, unabhängig vom Vorherrschen bestimmter Risikofaktoren für GDM, ein oraler Glukose-Challenge-Test (50-g-GCT) zum Screening auf Glukosestoffwechselstörungen und GDM angeboten werden. Fällt dieser Screeningtest pathologisch aus, erfolgt ein standardisierter oraler Glukosetoleranztest (75-g-oGTT), um den Verdacht auf GDM oder Diabetes mellitus zu bestätigen. Die sichere Diagnose des GDM hängt dabei nicht nur von der korrekten Durchführung des 75-g-oGTT ab, sondern vor allem auch von der richtigen (prä-)analytischen Handhabung der Blutproben.
High-intensity Interval Training Shock Microcycle Improves Running Performance but not Economy in Female Soccer Players
Authors: Dolci Filippo , Kilding Andrew E. , Spiteri Tania , Chivers Paola , Piggott Benjamin , Maiorana Andrew , Hart Nicolas 
Published: December 2020

AbstractThis study aimed to evaluate the effect of high-intensity interval training shock microcycles (HIITSM) on endurance, running economy and change of direction economy in female soccer players. Nineteen sub-elite female soccer players were randomised to two groups: HIITSM (10 HIIT sessions over 13 days) or HIITTRAD (4 HIIT sessions over 13 days) interventions. Endurance performance was evaluated through the 30–15 intermittent fitness test (30–15IFT); running economy over a 5-min treadmill run; and change of direction economy over two conditions: (1) 5-min 20m shuttle run, and (2) 5-min 10m shuttle run. HIITSM significantly improved 30–15IFT scores compared to baseline (+4.4%, p=0.009; d=0.96) and 30–15IFT scores relative to HIITTRAD (p=0.002; d=2.01). There was no significant interaction (group×time) for running economy and change of direction economy. Pre- to post- intervention there was a significant main time effect for blood lactate over 20m and 10m shuttle runs (p<0.001 and p=0.037, respectively), with large (d=0.93) and moderate (d=0.53) changes observed for the HIITSM over the two distances, respectively. HIITSM may be more effective than HIITTRAD to improve 30–15IFT over shorter training periods but may not affect running economy and change of direction economy.
Age-Dependent Anticoagulant Therapy for Atrial Fibrillation Patients with Intermediate Risk of Ischemic Stroke: A Nationwide Population-Based Study
Authors: Choi Sun Young , Kim Moo Hyun , Lee Kwang Min , Cho Young-Rak , Park Jong Sung , Yun Sung-Cheol , Lip Gregory Y. H. 
Published: December 2020

Abstract
Background Although older age is one of the most important risk factors for stroke in atrial fibrillation (AF), it is unclear whether an age threshold exists for which oral anticoagulants (OACs) are beneficial for intermediate-risk AF patients. We sought to investigate the age-dependency of OAC for ischemic stroke in intermediate-risk AF patients.
Methods We enrolled 34,701 AF patients (males with a CHA2DS2-VASc score of 1 and females with a CHA2DS2-VASc score of 2) using the Korean National Health Insurance Service database. The clinical endpoint was the occurrence of ischemic stroke and a composite outcome (ischemic stroke + major bleeding + all-cause death).
Results In AF patients aged ≥ 55 years, OAC therapy was associated with a lower risk of ischemic stroke compared with non-OAC treatment in males (55–59 years: hazard ratio [HR] 0.79, 95% confidence interval [CI] 0.61–0.98, p = 0.038, 60–64 years: HR 0.78, 95% CI 0.61–0.96, p = 0.029, and 65–74 years: HR 0.66, 95% CI 0.49–0.84, p = 0.011) and females (55–59 years: HR 0.76, 95% CI 0.58–0.96, p = 0.027, 60–64 years: HR 0.73, 95% CI 0.55–0.93, p = 0.017, and 65–74 years: HR 0.69, 95% CI 0.51–0.87, p = 0.013). OAC was associated with a lower risk for the composite outcome compared with non-OAC for male and female patients aged ≥ 55 years.
Conclusion Age is an important determinant of ischemic stroke and composite outcome in intermediate-risk AF patients. The benefit of OAC therapy for these AF patients appears to have an age threshold (age ≥ 55 years).
Therapy of Intermediate-Stage Hepatocellular Carcinoma: Current Evidence and Clinical Practice
Authors: Chai Nathan X. , Chapiro Julius 
Published: December 2020

AbstractIntermediate-stage Hepatocellular Carcinoma (HCC) represents a wide range of disease burden. Patients with different levels of liver function, tumor size, and number of lesions may all have intermediate-stage disease according to the Barcelona Clinic Liver Cancer (BCLC) staging system. Several minimally invasive image-guided locoregional therapies are available for the treatment of intermediate-stage HCC, including conventional transarterial chemoembolization (cTACE), drug-eluting bead TACE (DEB-TACE), yttrium-90 radioembolization (Y-90 RE), thermal ablation, bland embolization, and combination therapy. Available clinical evidence points to cTACE as the current gold standard for the locoregional treatment of intermediate-stage HCC. DEB-TACE is at best non-inferior to cTACE in terms of survival benefit. Y-90 RE is a maturing therapy, and some institutions have adopted it as first-line therapy for intermediate-stage HCC. Thermal ablation combined with TACE may be used in select patients, while bland embolization has only limited evidence for its use. The combination of locoregional therapy with VEGF inhibitors or immune checkpoint inhibitors has also been explored. This article will examine in detail the clinical evidence supporting available locoregional treatment options for intermediate-stage HCC.
Interventional Treatment of Hepatic Metastases from Colorectal Cancer
Authors: Sutphin Patrick D. , Ganguli Suvranu 
Published: December 2020

AbstractModern systemic therapies provide a significant survival benefit in metastatic colorectal cancer. Despite these advances, the durability of response remains limited and nearly all patients progress on systemic treatment. Colorectal liver metastases (CLM) develop in approximately half of patients with metastatic disease and contribute to mortality in most patients. In selected patients, surgical resection of hepatic metastases prolongs survival, indicating the benefits of the targeted treatment of CLM through alternate means. Minimally invasive interventional treatments offer the promise of treating CLM in a wider range of patients than those eligible for surgical resection. Thermal ablation and intra-arterial therapies, including chemoembolization and radioembolization, are commonly used in the treatment of CLM. Each of these treatment modalities will be discussed in detail with an emphasis on the available clinical data for each interventional treatment for CLM.
Liver-Directed Therapy for Neuroendocrine Tumor Liver Metastases in the Era of Peptide Receptor Radionuclide Therapy
Authors: Lehrman Evan D. , Fidelman Nicholas 
Published: December 2020

AbstractNeuroendocrine tumor liver metastases are treated by a multidisciplinary cohort of physicians that work together to achieve optimal clinical results for their patients. This review addresses critical concepts in diagnosis and workup of such patients followed by medical, surgical, and liver-directed arterial and ablative therapies. Specific perioperative care for these patients is crucial in avoiding dreaded complications related to Carcinoid Crisis. The recent introduction of Peptide Receptor Radionuclide Therapy as a therapeutic option has impacted some of the algorithms for timing and selection of arterial embolotherapies.
High Thrombin Generation after Acute Ischemic Stroke or Transient Ischemic Attack Is Associated with a Reduced Risk of Recurrence: An Observational Cohort Study
Authors: Lundström Annika , Änggårdh-Rooth Elisabeth , Mobarrez Fariborz , Thålin Charlotte , Gigante Bruna , Laska Ann Charlotte , Wallén Håkan 
Published: December 2020

AbstractThrombin is increasingly recognized to be of importance for cardiovascular disease. The aim of this study was to investigate the prognostic value of thrombin generation variables in a cohort of patients with acute ischemic stroke (AIS) or transient ischemic attack (TIA). Thrombin generation potential measured by calibrated automated thrombogram (CAT) and prothrombin fragment F1 + 2 was determined in the acute and convalescent phases for a cohort of 190 patients with AIS/TIA. Microvesicle (MV)-induced thrombin generation potential was determined for a subset of patients using modified CAT. Primary outcome was a composite of fatal and nonfatal AIS or myocardial infarction as documented in Swedish registers during a total follow-up of 986 patient-years. Hazard ratios (HRs) were calculated using Cox regression based on variable median split. Peak thrombin and endogenous thrombin potential (ETP) above median in the acute phase were associated with a reduced risk of primary outcome after adjustment for cardiovascular risk factors, HR: 0.50 (0.27–0.92), p = 0.026 and HR: 0.53 (0.28–0.99), p = 0.048, respectively. F1 + 2 was lower in patients than in healthy controls but not associated with outcome. MV-induced peak thrombin above median in the acute phase was associated with recurrent AIS, unadjusted HR: 2.65 (1.03–6.44), p = 0.044. Contrary to expectation, high thrombin generation potential is associated with a reduced risk of recurrent ischemic event in patients with AIS/TIA. Low ETP/peak thrombin combined with high MV-induced peak thrombin can potentially identify patients at high risk of recurrence.