bluuebunny/crossref_metadata_2025_split huggingface dataset:
Attacking the SARS-CoV-2 Replication Machinery with the Pathogen Box’s Molecules
Authors: Osorio-Mogollon Cleidy , Olivos-Ramirez Gustavo E. , Otazu Kewin , Chenet-Zuta Manuel E. , Ropon-Palacios Georcki , Camps Ihosvany , Jimenez-Avalo Gabriel M. , Apari-Cossio Eduardo , Torres-Moreira Natalia E. , Cardenas-Cardenas Reyna G. 
Published: June 2020

The world is currently facing a pandemic caused by the new 2019 coronavirus disease (COVID-19), caused by SARS-CoV-2. Among the fundamental processes of this virus are viral transcription and replication. They allow the synthesisof genetic material and the consequent multiplication of the virus to infect other cells or organisms. These are performed by a multi-subunit machinery of various nonstructural proteins (nsp); among which the RNA-dependent RNApolymerase (RdRp or nsp12) is the most important, and, at the same time, conserved among coronaviruses. The structure of this protein (PDB ID: 6M71) was used as a target in the application of computational strategies for drugsearch, like virtual screening and molecular docking. The region considered for virtual screening has three important amino acids for protein catalysis: T680 (located in Motif A), N691 and D623 (located in Motif B), where a grid box was located. In turn, applying the concept of drug repositioning isconsidered as a quick response in the treatment of sudden outbreaks of diseases. Here, we used the Pathogen Box, a database of chemical compounds analyzed for the treatment against malaria, which were filtered under the criteria of selecting those that do not present any violation of Lipinski'sRule of Five. At the same time, the Remdesivir, Beclabuvir and Sofosbuvir drug, previously used in in silico and clinical studies for inhibition of nsp12, were used as positive controls. The results showed a Top10 potential target inhibitors, with binding energy higher than those of the positive controls, of which TCMDC-134153 and TCMDC-135052, both with -7.53 kcal/mol, present interactions with the three important residues of the nsp12 catalytic site. These proposed ligands would be used for subsequent validation by molecular dynamics, where they can beconsidered as drugs for the development of effective treatments against this new pandemic.
Pengaruh Kelompok Kerja Guru (KKG) Terhadap Peningkatan Kompetensi Pedagogik dan Kemampuan Menulis Karya Ilmiah
Authors: Palettei Arsyad Djamaluddin , Sulfemi Wahyu Bagja 
Published: June 2020

Penelitian ini bertujuan mengetahui pengaruh peningkatan kompetensi pedagogik guru dan kemampuan penulisan kemampuan menulis karya ilmiah guru terhadap Kegiatan Kelompok Kerja Guru (KKG). Metode yang digunakan dalam penelitian ini adalah metode survei dengan teknik analisis jalur (<em>path analysis</em>) untuk memperoleh fakta-fakta dari gejala-gejala yang ada dan mencari keterangan secara factual dengan menggunakan pendekatan kuantitatif sebagai tumpuan analisis teknik regresi untuk menguji hipotesis yang menyatakan ada atau tidak pengaruh variabel bebas (X<sup>1</sup>) dan (X<sup>2</sup>) dengan variabel terikat (Y). Populasi dalam penelitian ini adalah guru Sekolah Dasar (SD) anggota KKG Gugus 1 dan 2 Kecamatan Ciampea sebanyak 95 orang dengan jumlah Sampel penelitian ini berjumlah 25 guru. Hasil dari penelitian, <em>pertama</em>, terdapat pengaruh positif kegiatan KKG (Y) terhadap pengingkatan kompetensi pedagogik guru (X<sup>1</sup>), dengan indeks korelasi r y<sup>1</sup> = 3,27 dengan hasil uji koefisien korelasi yang signifikan pada α = 5 % serta diperjelas bahwa 80 % variasi Y dipengaruhi oleh X<sup>1</sup>. <em>Kedua,</em> terdapat pengaruh kegiatan KKG (Y) dengan kemampuan menulis karya ilmiah (X<sup>2)</sup>, dengan koefisien korelasi r y<sup>2</sup> = 3,32 dengan hasil uji koefisien korelasi yang signifikan pada α = 5 % serta diperjelas bahwa 80 % variasi Y dipengaruhi oleh X<sup>2</sup>. <em>Ketiga</em> terdapat pengaruh positif kegiatan KKG (Y) dengan pengingkatan kompetensi pedagogik guru (X<sup>1</sup>) dan kemampuan menulis karya ilmiah (X<sup>2)</sup>, dengan koefisien korelasi ganda Ry.12 = 4,76 dengan hasil uji koefisien korelasi yang signifikan pada α = 5 % serta diperjelas bahwa 80 % variasi Y dipengaruhi oleh X<sup>1 </sup>dan X<sup>2</sup>. Melalui analisa pengujian diperoleh bahwa koefisen korelasi dan koefisien regresi tersebut sangat signifikan. Hal tersebut membuktikan bahwa terdapat hubungan yang positif dan sangat signifikan antara peningkatan kompetensi pedagogik dan kemampuan menulis karya ilmiah dengan kegiatan KKG.
PENINGKATAN KEMAMPUAN GURU DALAM MELAKSANAKAN PENDEKATAN SERU MELALUI TINDAKAN TINDAK LANJUT SUPERVISI KUNJUNGAN KELAS OLEH KEPALA SEKOLAH
Authors: Sugiarti Sugiarti 
Published: June 2020

Penelitian kegiatan supervisi ini dilakukan oleh Kepala Sekolah agar dapat memperbaiki atau meningkatkan kualitas dari pembelajaran SERU yang telah diterapkan oleh guru-guru SDN 84 Singkawang. Prosedur penelitian dilaksanakan dengan menggunakan siklus-siklus tindakan (daur ulang) yang meliputi perencanaan (<em>Planning</em>), tindakan (<em>Action</em>), mengobservasi (<em>Observation</em>), dan melakukan refleksi (<em>Reflection</em>). Penelitian Tindakan Sekolah (PTS) ini dilakukan di SD Negeri 84 Singkawang, Kecamatan Singkawang Utara Kota Singkawang pada semester II Tahun pelajaran 2016-2017. Hasil supervisi keterampilan guru dalam penerapan pendekatan pembelajaran SERUsiklus 1 masih kurang dan mengalami peningkatan pada siklus 2. Data hasil penilaian RPP juga mengalami peningkatan. Dilihat dari dari segi siswa terlihat adanya peningkatan parrtisipasi siswa dalam kegiatan belajar mengajar. Data hasil observasi menunjukkan bahwa aktivitas siswa dalam kelas 1mencapai rata-rata skor 5,79 (cukup), dalam kelas 2 mencapai (cukup). Kelas 3 mencapai skor rata-rata 7,12 (baik), kelas 4 mencapai 7,30 (baik), dan kelas 5 mencapai 7,44 (Baik). Hal tersebut menunjukkan bahwa aktivitas siswa telah mengalami peningkatan namun belum mencapai katagori baik sehingga perlu ditingkatkan.
Methods of Organization of Spoc Course on Planimetry Training for Future Teachers of Mathematics
Authors: Dyupina Anastasiya , Falileeva Marina 
Published: June 2020

The article presents using the van Hiele theory of geometric thinking for the organization of mixed training of students of the pedagogical Department of the N.I. Lobachevsky Institute of mathematics and mechanics KFU on the basis of SPOC course «Elementary mathematics: Plane geometry». Training includes the use of various IT-techniques and tools that can improve the quality of learning and form the necessary professional competence of the future teacher of mathematics. The course implements the technology of project-modular and inverted learning.
José Joaquín Parra Bañón. El oído melancólico y Arquitectura de la melancolía
Authors: Bou Enric 
Published: June 2020

Review of Parra Bañón, J.J. (2018). El oído melancólico. Expresión e imágenes de la acufenolipemanía. Barcelona: Lumen. 234 pp.; Parra Bañón, J.J. (2019). Arquitectura de la melancolía. Sevilla: Athenaica Ediciones, pp. 312.
Jon Kortazar (ed.). Bridge / Zubia : Imágenes de la relación cultural entre el País Vasco y Estados Unidos
Authors: Verbeke Frederik 
Published: June 2020

Review of Kortazar, J. (ed.) (2019). Bridge / Zubia: Imágenes de la relación cultural entre el País Vasco y Estados Unidos. Madrid; Frankfurt: Iberoamericana; Vervuert, pp. 410.
Syn-eruptive agglutination of kimberlite volcanic ash
Authors: Haddock David , Manya Shukrani , Brown Richard James , Jones Thomas , Wadsworth Fabian , Dobson Kate , Gernon Thomas 
Published: June 2020

Pyroclastic deposits of the Holocene Igwisi Hills kimberlite volcanoes, Tanzania, preserve unequivocal evidence for rapid, syn-eruptive agglutination. The unusual pyroclasts are composed of ash-sized particles agglutinated to each other by thin necks. The textures suggest the magma was disrupted into droplets during ascent. Collisions between particles occurred within a volcanic plume and on deposition within the conduit to form a weakly agglutinated, porous pyroclastic deposit. Theoretical considerations indicate that agglutination occurred over short timescales. Agglutinated clasts were entrained into weak volcanic plumes and deposited around the craters. Our results support the notion that agglutination can occur during kimberlite eruptions, and that some coherent, dense rocks in ancient kimberlite pipes interpreted as intrusive rocks could instead represent agglutinated pyroclastic rocks. Differentiating between agglutinated pyroclastic rocks and effusive or intrusive rocks in kimberlite pipes is important because of the potential effects that pyroclastic processes might have on diamond concentrations in deposits.
The Membership of Governors’ Teams in Russia’s Regions, and the Key Features of the Formation of Regional Administrations 1991–2018
Authors: Kynev Alexander 
Published: June 2020

Abstract
This article examines the outcomes of renewal of personnel in the Russian regional authorities during different stages of their development: 1991–1995 (primarily assigned based on elections in individual regions), 1995–2005 (the period of mass direct elections), 2005–2012 (a system of appointment based on the president’s nomination), and 2012–2018 (elections via a municipal filter). It attempts to aggregate and analyse the instances where the heads of regional authorities were elected (or appointed) despite having no previous relationship to those regions (outsider politicians). It offers a classification system for these outsiders, distinguishing “pure outsiders”, “returnees”, “adapted outsiders”, “naturalised outsiders” and “federalised locals”.
Improvement in seed germination by priming treatments in Black nightshade (Solanum nigrum L.)
Authors: Poovizhi M , Sujatha K 
Published: June 2020

The seeds must be viable and non-dormant for the efficient cultivation of the species of medicinal plants. The seeds of Solanum nigrum possess primary dormancy, which restricts germination. Hence, a laboratory experiment was conducted during 2019 in the Department of Seed Science and Technology, Agricultural College and Research Institute, Madurai, Tamil Nadu. The S. nigrum seeds were primed by soaking in different chemicals viz.,GA3 100ppm, Thiourea1%, KNO3 0.5%, Succinic acid 100 ppm, Ascorbic acid 100 ppm, hydro and dry control with soaking durations of 12h and seeds were dried under shade to bring back to their original moisture content and used for assessing the seed quality studies. The results revealed that among the different priming treatments Thiourea 1% recorded higher seed quality parameters viz, speed of germination (5.6), germination (88 %), seedling length (5.92 cm) and vigour index (520) and the enzyme activity of dehydrogenase (0.072 OD value) and lower values of electrical conductivity( 0.027 dsm-1), amino acids (0.119 ?gg-1 ) and sugars ( 0.175 ?gg-1 ). Hence it could be recommended as pre-sowingg seed priming treatment in S. nigrum.
Prospects of biodrainage to mitigate problems of waterlogging and soil salinity in context of India - A review
Authors: Masilamani P. , Arulmozhiselvan K. , Alagesan A. 
Published: June 2020

Major parts of agricultural lands in arid and semi-arid regions of India are affected by soil salinity and waterlogging in canal command area and outside. Waterlogging is caused by a rising water table and poor drainage conditions. Stress due to waterlogging and salinity are serious to plants in all stages from seed germination to active growth and maturity. Unmanaged affected agricultural lands turn into low productive marshlands in the long run. Physical provision of surface or sub-surface drainage structures can rescue in such a situation. Yet, high skill and investment are required in the installation and maintenance of such structures. Alternatively, biodrainage method has been evolved as an effective method recently world over. In biodrainage, plants are raised over a larger area, which can transpire and remove an enormous amount of water from the soil. Plants having adequate adaptive traits and tolerance mechanisms are desirable to mitigate waterlogging and salinity. Biodrainage is suitable in rainfed and irrigated conditions. Planting of right plant species in optimum population and geometry decides the efficiency of biodrainage. Further, combining biodrainage with the conventional drainage can improve land and water productivity. Eucalyptus is the most suitable tree species for biodrainage as it has well performed in versatile environments. It possesses appreciable tolerance to salinity, sodicity and waterlogged conditions of the soil. Fast-growing with a straight trunk, deep rooting ability, low shading effect and high transpiration capacity are promising characteristics of this tree. Prominent woody species like Acacia nilotica, Dalbergia sissoo, Hardwickia binata can also be grown for high profit.
Manifestaciones neurológicas del COVID-19
Authors: Ocampo Rojas Sebastián Joaquín 
Published: June 2020

Estimado Director:
Leyendo su artículo “La pandemia por el nuevo coronavirus covid-19”, me gustaría profundizar los aportes de la sintomatología de esta enfermedad. Lo que ha comenzado como una patología manifestada por un síndrome respiratorio como neumonías atípicas, actualmente está asociada a varias manifestaciones no respiratorias(1).
De las primeras manifestaciones neurológicas reportadas está el síndrome de Guillain-Barré en una viajera proveniente de Wuhan(2). La literatura es rica en cuanto a cefaleas, convulsiones e ictus en los pacientes graves, si bien la primera y última de estas pueden deberse a complicaciones sistémicas de este novel coronavirus, se ha reportado una mayor incidencia de eventos en pacientes con antecedentes de manifestaciones neurológicas(3,4).
Una de las más recientes manifestaciones reportadas, son las enfermedades neuromusculares. Guidon et al. critican la falta de rigurosidad en los reportes sobre manifestaciones neuromusculares(4).
Si algo es seguro, una manifestación de esta pandemia es la gran cantidad de información disponible en el ámbito científico, muchas veces de estas sin la misma rigurosidad metodológica anterior a la pandemia, acentuando la responsabilidad del lector de analizar críticamente toda la información.
Giftedness as a Pedagogical Problem
Authors: Tomilov Vladimir Anatolevich , Krivenko Margarita Maksimovna 
Published: June 2020

The difference between the concepts of ability and giftedness in the context of a competency approach to education, when competence and expert knowledge are distinguished is clarified in the article. It is understood that the level of subject competencies characterizes an individual subject with regard to his or her abilities, which distinguishes one student from another through the content understanding and fast retention of learning material.
The aim of the study is to show how the educational process is regulated by rational and emotional consciousness and how emotional consciousness, being associative, allows the student to use his or her life experience as a means of indirect influence on his or her behavior using the metaphors of A. N. Veraksa in the educational process. The author outlines that the competence of a student is his or her talent or giftedness, which is manifested in interaction with other students, that is, in a team: the student is an individual and collective subject of the educational process, and his or her activity regulates rational and emotional consciousness, so the task is to determine the forms of their integration in the educational process. It is noted that if the student's abilities are manifested in interaction with others, the successful/unsuccessful one is not an individual here, but a collective (group) subject. It is mentioned that in terms of B.M. Teplov, it is referred to “giftedness” in the form of a combination of individual abilities of participants in the educational process (situation), through which a chance for success in educational activities increases or reduces. It is concluded that in preschool and primary school age, an effective form of indirect influence is a fairy tale, and hereinafter – project activity, mediated in the student's mind by the metaphor of creativity, which puts the development of emotional consciousness under the control of the teacher.
Holding Online Student Conferences: Typical Mistakes
Authors: Kochkareva Irina Vitalevna 
Published: June 2020

The article is focused on the analysis of typical mistakes and errors which are made by Russian students while creating PowerPoint presentations and delivering them at online international conferences. The relevance of the topic is connected with the necessity to face a new challenge of transforming the educational process into the new format – the format of distance learning. The author of the article outlies that this transformation should be carried out very carefully. Digitalization of education system should not result in painful destruction of traditional approaches to teaching and learning. It is noted that it is necessary to continue using those forms of educational process which are familiar both for teachers and students. One of such forms is an online student conference. The aim of the research was to analyze different types of mistakes and errors made by Russian students as well as their main causes. The author deals with examples collected while listening to presentations at the international online conferences which were held at the faculties of biology at Perm State University and the university of Delta, USA. The methods used in the research include analysis, description, observation, comparison. The results of the research demonstrated that one of the most common causes of mistakes is language interference. It is concluded that the analysis of typical mistakes and errors helps the teacher to make the right choice of materials for drilling in class, which, in turn, is crucial for language competence development that makes effective professional communication possible.
Surgical management of carcinomas of the infratemporal fossa and skull base: patterns of failure and predictors of long-term outcomes
Authors: Amit Moran , Bell Diana , Hunt Patrick J. , Hanna Ehab , Su Shirley Y. , Kupferman Michael , Aashiq Mohamed , Takahashi Hideaki , Gidley Paul W. , Nader Marc-Elie , DeMonte Franco , Raza Shaan M. 
Published: June 2020

OBJECTIVE
Infratemporal fossa (ITF) tumors are unique in histological characteristics and difficult to treat. Predictors of patient outcomes in this context are not known. The objective of this study was to identify independent predictors of outcome and to characterize patterns of failure in patients with ITF carcinoma.

METHODS
All patients who had been surgically treated for anterolateral skull base malignancy between 1999 and 2017 at the authors’ institution were retrospectively reviewed. Patient demographics, preoperative performance status, tumor stage, tumor characteristics, treatment modalities, and pathological data were collected. Primary outcomes were disease-specific survival (DSS) and local progression-free survival (LPFS) rates. Overall survival (OS) and patterns of progression were secondary outcomes.

RESULTS
Forty ITF malignancies with skull base involvement were classified as carcinoma. Negative margins were achieved in 23 patients (58%). Median DSS and LPFS were 32 and 12 months, respectively. Five-year DSS and OS rates were 55% and 36%, respectively. The 5-year LPFS rate was 69%. The 5-year overall PFS rate was 53%. Disease recurrence was noted in 28% of patients. Age, preoperative performance status, and margin status were statistically significant prognostic factors for DSS. Lower preoperative performance status and positive surgical margins increased the probability of local recurrence.

CONCLUSIONS
The ability to achieve negative margins was significantly associated with improved tumor control rates and DSS. Cranial base surgical approaches must be considered in multimodal treatment regimens for anterolateral skull base carcinomas.
Direct versus indirect bypass procedure for the treatment of ischemic moyamoya disease: results of an individualized selection strategy
Authors: Nielsen Troels H. , Abhinav Kumar , Sussman Eric S. , Han Summer S. , Weng Yingjie , Bell-Stephens Teresa , CNRN  , Heit Jeremy J. , Steinberg Gary K. 
Published: June 2020

OBJECTIVE
The only effective treatment for ischemic moyamoya disease (iMMD) is cerebral revascularization by an extracranial to intracranial bypass. The preferred revascularization method remains controversial: direct versus indirect bypass. The purpose of this study was to test the hypothesis that method choice should be personalized based on angiographic, hemodynamic, and clinical characteristics to balance the risk of perioperative major stroke against treatment efficacy.

METHODS
Patients with iMMD were identified retrospectively from a prospectively maintained database. Those with mild to moderate internal carotid artery or M1 segment stenosis, preserved cerebrovascular reserve, intraoperative M4 segment anterograde flow ≥ 8 ml/min, or the absence of frequent and severe transient ischemic attacks (TIAs) or stroke had been assigned to indirect bypass. The criteria for direct bypass were severe ICA or M1 segment stenosis or occlusion, impaired cerebrovascular reserve or steal phenomenon, intraoperative M4 segment retrograde flow or anterograde flow < 8 ml/min, and the presence of frequent and severe TIAs or clinical strokes. The primary study endpoint was MRI-confirmed symptomatic stroke ≤ 7 days postoperatively resulting in a decline in the modified Rankin Scale (mRS) score from preoperatively to 6 months postoperatively. As a secondary endpoint, the authors assessed 6-month postoperative DSA-demonstrated revascularization, which was classified as < 1/3, 1/3–2/3, or > 2/3 of the middle cerebral artery territory.

RESULTS
One hundred thirty-eight patients with iMMD affecting 195 hemispheres revascularized in the period from March 2016 to June 2018 were included in this analysis. One hundred thirty-three hemispheres were revascularized with direct bypass and 62 with indirect bypass. The perioperative stroke rate was 4.7% and 6.8% in the direct and indirect groups, respectively (p = 0.36). Degree of revascularization was higher in the direct bypass group (p = 0.03). The proportion of patients improving to an mRS score 0–1 (from preoperatively to 6 months postoperatively) tended to be higher in the direct bypass group, although the difference between the two bypass groups was not statistically significant (p = 0.27).

CONCLUSIONS
The selective use of an indirect bypass procedure for iMMD did not decrease the perioperative stroke rate. Direct bypass provided a significantly higher degree of revascularization. The authors conclude that direct bypass is the treatment of choice for iMMD.