bluuebunny/crossref_metadata_2025_split huggingface dataset:
Severe Pelvic Fracture in the Elderly: High Morbidity, Mortality, and Resource Utilization
Authors: Garcia Monika , Firek Matthew , Zakhary Bishoy , Brenner Megan , Hildebrand Frank , Coimbra Raul 
Published: October 2020

Severe pelvic fractures (PF) in the elderly are common and analysis of outcomes and resource utilization are lacking. Using the National Trauma Databank (2007-2016), 13 267 patients aged ≥65 years with severe PF (Abbreviated Injury Scale [AIS] pelvis ≥3; AIS 3 = 10 388; AIS 4 = 2124; AIS 5 = 805) were studied. Demographic data, management, resource utilization, complications, and mortality were analyzed for each group. Data are represented as % or median interquartile range (IQR). Multivariate logistic regression analyzed risk factors for mortality, Intensive Care Unit (ICU) admission, and ventilator use. Median age was 77, and most of them were females (59%). Falls occurred in 52%, motor vechicle crash in 21.5%, and pedestrian struck in 11.6%. Median injury severity score was 16 (IQR: 9,27). Shock on admission (9.4%) increased with injury severity. Glasgow Coma Scale < 8 occurred in 8%. Blood transfusion increased with injury severity (17%, 29%, and 51%). Angiography occurred in 9%, external fixation in 4%, internal fixation in 16%, and pelvic packing in 1%, the majority in the AIS 5 group. Overall, 46% required ICU admission and 30% underwent mechanical ventilation; median Hospital Length of Stay was 6 (IQR 4,11), ICU length of stay was 5 (IQR 2,10), and median ventilator days were 4 (IQR 1-11). Mortality rate was 13.3% (AIS 3 = 10%, AIS 4 = 19%, and AIS 5 = 44%).Severe PF in the elderly is associated with high resource utilization, complications, and mortality.
Low-cost procedure for deformity correction in rheumatoid hands
Authors: Agarwal Pawan , Vaishya Raju , Sharma Dhananjaya 
Published: October 2020

Background Surgical correction of ulnar drift of metacarpo-phalangeal joint (MPJ) due to Rheumatoid arthritis (RA) is conventionally done by silicon joint arthroplasty which is expensive and may be associated with many complications. We report the outcome of low-cost autologous interpositional arthroplasty. Material and methods Five patients (8 hands, 32 arthroplasties) underwent correction of ulnar drift of MPJ by dorsal capsule interpositional arthroplasty. Results were assessed according to the degree of recovery of movement at the MPJ and correction of ulnar drift. Functional improvement was graded as excellent, good and fair. Pain alleviation was assessed by visual analogue score (VAS) score. Results Excellent results were seen in 3 patients (5 hands, 20 arthroplasties), good in 1 patient (2 hands, 8 arthroplasties) and fair in 1 patient (1 hand, 4 arthroplasties). VAS score for pain decreased from mean preoperative 8.2/10 to 1/10. On average follow up of 1.4 years there was good hand function, no recurrence of deformities and patients were pain free. Conclusion Interpositional arthroplasty for MPJ using dorsal capsule for correction of post RA ulnar drift is a low-cost option which improves the hand function and cosmesis. Additionally, it avoids all the complications related with the use of silicon joints.
A refractory anti-NMDA receptor encephalitis successfully treated by bilateral salpingo-oophorectomy and intrathecal injection of methotrexate and dexamethasone: a case report
Authors: Wang Dongmei , Wu Yongming , Ji Zhong , Wang Shengnan , Xu Yunqi , Huang Kaibin , Peng Yu , Zheng Hui , Wang Honghao , Zhang Xiaomei , Pan Suyue 
Published: October 2020

Introduction Anti-N-methyl-D-aspartate (anti-NMDA) receptor encephalitis is an autoimmune-mediated disease that is common in young female patients with ovarian teratomas. With appropriate immunotherapy, most patients achieve a good prognosis. Nevertheless, some patients may be refractory to first- and second-line immunotherapy, thus alternative treatments are required for these patients. Case presentation: We present a case of anti-NMDA receptor encephalitis with ovarian teratoma. After the prompt removal of the teratoma and intense immunotherapy was administered, including an intravenous methylprednisolone pulse, intravenous immunoglobin, plasmapheresis, immunoadsorption, intravenous cyclophosphamide, and rituximab, the patient’s neurologic status did not improve. Bilateral salpingo-oophorectomy was then conducted, and intrathecal injection of methotrexate (MTX) and dexamethasone (DXM) was performed. The patient’s neurological symptoms improved dramatically, and she achieved a good prognosis after 23 months. Conclusions Intrathecal injection of MTX and DXM may be beneficial for treatment of refractory cases of anti-NMDA receptor encephalitis. Additional research is required to elucidate the mechanisms of intrathecal treatment with this therapy.
Highly oxidized low-density lipoprotein does not facilitate platelet aggregation
Authors: Miyazaki Akari , Uehara Takeshi , Usami Yoko , Ishimine Nau , Sugano Mitsutoshi , Tozuka Minoru 
Published: October 2020

Objective This study aimed to examine whether oxidized low-density lipoprotein (oxLDL) facilitates platelet aggregation, which is one cause for development of cardiovascular disease. Methods The susceptibility of platelets to aggregation was monitored by light transmittance aggregometry and a laser light scattering method using low-density lipoprotein (LDL) and oxLDL as agonists. β-thromboglobulin (β-TG) levels released from platelets were also measured after incubation with or without oxLDL. Results Platelet aggregation was suppressed by oxLDL as estimated by maximum light transmission. Additionally, adenosine diphosphate-induced further aggregation was slightly reduced by the presence of oxLDL. Aggregation levels of a low number of platelets, which was determined by the laser light scattering method, were lower upon addition of oxLDL compared with unoxidized LDL. After a short time of incubation, oxLDL increased secreted β-TG levels in platelet-rich plasma. However, further incubation with oxLDL caused relatively lower secreted β-TG levels compared with incubation with unoxidized LDL. This fluctuation was not due to β-TG degradation by oxLDL. Conclusions Levels of oxLDL in vitro weakly activate platelets at an early stage, but then inhibit platelet function, such as aggregation and β-TG secretion.
Association between miR-492 rs2289030 G>C and susceptibility to Hirschsprung disease in southern Chinese children
Authors: Zheng Yi , Liu Yanqing , Wang Mi , He Qiuming , Xie Xiaoli , Lu Lifeng , Zhong Wei 
Published: October 2020

Objective Hirschsprung disease (HSCR) originates from disruption of normal neural crest cell migration, differentiation, and proliferation during the fifth to eighth weeks of gestation. This results in the absence of intestinal ganglion cells in the distal intestinal tract. However, genetic variations affecting embryonic development of intestinal ganglion cells are unclear. Therefore, this study aimed to investigated the potential value of miR-492 rs2289030 G>C as a marker of susceptibility to HSCR Methods In this case–control study in southern Chinese children, we collected samples from 1473 controls and 1470 patients with HSCR. TaqMan genotyping of miR-492 rs2289030 G>C was performed by real-time fluorescent quantitative polymerase chain reaction. Results Multivariate logistic regression analysis showed that there was no significant association between the presence of the miR-492 rs2289030 G>C polymorphism and susceptibility to HSCR by evaluating the values of pooled odds ratios and 95% confidence intervals. Similarly, among different HSCR subtypes, rs2289030 G>C was also not associated with HSCR in hierarchical analysis. Conclusions Our results suggest that the miR-492 rs2289030 G>C polymorphism is not associated with susceptibility to HSCR in southern Chinese children. These results need to be further confirmed by investigating a more diverse ethnic population of patients with HSCR.
Chromatographic and spectroscopic determination of solvent-extracted Lantana camara leaf oil
Authors: Ayalew Adane Adugna 
Published: October 2020

Objective This study aimed to determine the chemical profile of Lantana camara leaf oil. Methods The essential oil was extracted from dried leaf samples using the Soxhlet extraction method. The oil was separated from the solvent and the bioactive compounds were identified using gas chromatography–mass spectroscopy (GC-MS) and Fourier transform infrared spectroscopy (FTIR). The identified peaks in the mass spectrum were matched with the database of the US National Institute of Standards and Technology (NIST) library. Results The FT-IR results indicated the presence of alcohols, carboxylic acids, phenols, alkanes, ketones, and primary amine compounds. GC-MS identified 43 compounds representing 95% of the total leaf essential oil components. Some of the major isolated compounds included a pyrrolizine; 1-dodecanol; 1,2-nonadecanediol; phytol; 1,3-dioxolane; 4-undecene, 9-methyl, (Z)-; 1-eicosanol; and imidazole. Conclusions The identified constituents of the extracted oil have established pharmacologic and insecticidal activities, and these compounds are also used in the drink, food, and cosmetic industries. This extract is highly valuable for the medical treatment of various ailments.
Pretreatment plasma d-dimer levels as an independent prognostic factor for overall survival among patients with advanced non-small-cell lung cancer
Authors: Liu Qianfei , He Jianbo , Ning Ruiling , Tan Liping , Zeng Aiping , Zhou Shaozhang 
Published: October 2020

Objective To evaluate the prognostic accuracy of d-dimer levels for advanced non-small-cell lung cancer (NSCLC). Methods This retrospective cohort study included 651 patients initially diagnosed with advanced NSCLC. Patients with d-dimer levels ≥0.5 mg/L were included in the high d-dimer group, whereas patients with lower levels were included in the normal group. Cumulative survival was estimated using Kaplan–Meier curves and compared using the log-rank test. Multivariate analyses were performed using the Cox proportional hazards model. Results The median plasma d-dimer level in the study cohort was 0.61 ± 0.49 mg/L. d-dimer levels were elevated in 60.98% of patients, and 80.1% of such patients had adenocarcinoma. Univariate and multivariate analyses identified d-dimer content as an independent factor for the prognosis of NSCLC (hazard ratio [HR] = 1.54, 95% confidence interval [CI] = 1.19–1.98). Kaplan–Meier analysis revealed that high plasma d-dimer levels were associated with shorter overall survival (HR = 1.48, 95% CI = 1.19–1.84). In addition, the receipt of <2 lines of treatment was associated with a higher risk of death than the receipt of >2 lines. Conclusion The present results imply that pretreatment plasma d-dimer levels could represent a prognostic factor for advanced NSCLC.
Correlations between lipoprotein(a) gene polymorphisms and calcific aortic valve disease and coronary heart disease in Han Chinese
Authors: Dong Hongzhi , Cong Hongliang , Wang Jing , Jiang Yiyao , Liu Chao , Zhang Yingyi , Zhu Yanbo , Wang Qingtong 
Published: October 2020

Objective To investigate the relationship between lipoprotein(a) gene ( LPA) polymorphisms and calcific aortic valve disease (CAVD) and coronary heart disease (CHD) in Han Chinese. Methods A total of 148 patients were recruited (n = 71 with CAVD and n = 77 with CHD) based on a diagnosis achieved using color Doppler echocardiography, coronary angiography, or computed tomography angiography. Seventy-one control individuals without CAVD or CHD were also recruited. Biomarkers including levels of lipoprotein(a) [Lp(a)], low-density lipoprotein and high-density lipoprotein cholesterol, apolipoprotein A1, and apolipoprotein B were tested. LPA polymorphisms rs10455872, rs6415084, rs3798221, and rs7770628 were analyzed using SNaPshot SNP. Results Lp(a) levels were significantly higher in CAVD and CHD groups compared with controls. There was no significant difference in the allelic frequency distribution of rs3798221, rs7770628, or rs6415084 between CHD, CAVD, and control groups. Linear regression showed that rs3798221, rs7770628, and rs6415084 were associated with increased Lp(a) concentrations. Two CAVD patients among the 219 participants carried AG minor alleles at rs10455872, while the remainder carried AA minor alleles. Conclusion rs3798221, rs6415084, and rs7770628 polymorphisms within LPA are associated with higher Lp(a) plasma levels, which correlate with increased CAVD and CHD risks.
Comparative Evaluation of Dimensional Accuracy, Surface Characteristics, and Load Deflection Attributes of 0.019" × 0.025" Stainless Steel Wires Sourced from Six Different Commercial Houses: An In Vitro Study
Authors: Kolge Neeraj E , Patni Vivek J , Karandikar Girish , VK Ravindranath , Daga Prateek , Madhaswar Aarti B 
Published: October 2020

Aims & Objectives: The aim of the study was to evaluate and compare dimensional accuracy, surface characteristics and load deflection attributes of SS wires sourced from six different commercial houses. Materials & Methods: 0.019” x 0.025” SS wire samples were divided into 6 groups and evaluated and compared for the aforementioned properties. Dimensional accuracy, surface roughness, frictional resistance, load deflection rate and ultimate tensile strength were evaluated and compared. Results: Dimensional accuracy did not vary significantly. Surface Profilometry proved 3M Unitek (Group 1) to be the wire with least irregularities. According to SEM, Modern Orthodontics (Group 6) and 3M Unitek (Group 1) in terms of ‘Sa’ and ‘Sq’ respectively had the smoothest surface finish. SS wires sourced from G&H Orthodontics (Group 2) exhibited least frictional resistance. Load deflection rates varied for all the groups for all three parameters under the study. UTS was best for SS wires sourced from Rabbit Force Orthodontics (Group 5). Conclusion: No wire from a single commercial house excels in all the parameters that were evaluated, each one having its aces and minuses.
Developmental Dyspraxia in Children With Learning Disorders: Four-Year Experience in a Referred Sample
Authors: Waber Deborah P. , Boiselle Ellen C. , Yakut Ayse D. , Peek Carrie P. , Strand Kristine E. , Bernstein Jane H. 
Published: October 2020

Objective: The term apraxia is clearly understood in adult behavioral neurology, with assessment of gesture central to the diagnosis. In contrast, the concept of “developmental dyspraxia” has been more problematic. In an effort to better specify its potential significance, we describe preliminary practice-based evidence for understanding developmental dyspraxia acquired within a theoretical framework informed by both adult behavioral neurology and a neuroconstructivist appreciation of neurodevelopmental disorders. Specifically, we describe the experience of a diagnostic clinic for children with learning disorders that adopted this framework and compare clinical characteristics of children diagnosed with dyspraxia with those of children diagnosed with dyslexia during the same time period. Method: The dyspraxia diagnosis was based on the presence of impaired gesture and/or cognitive problems with planning. Over the target period, 71 children were diagnosed with dyspraxia and 114 children were diagnosed with dyslexia. Twenty-nine of the 71 children with dyspraxia were also diagnosed with dyslexia. Domains assessed included early developmental milestones, neurologic findings, cognition, speech and language, academic skills, and psychosocial functioning. Results: Compared to the dyslexia group, children with dyspraxia (with or without dyslexia) had more problems with speech and language planning and planning in everyday life. Children with dyspraxia without dyslexia had more frequent early motor delays and deficits in visuospatial production than the other groups. The dyslexia groups predictably demonstrated poorer single word reading and phonologic processing compared to the dyspraxia only group (all P < .01). Conclusions: A neurologic finding of impaired gesture in children with learning disorders may signal a broader neurodevelopmental profile of developmental dyspraxia with both theoretical relevance and meaningful implications for evaluation and treatment. Cognitive problems with planning are particularly relevant.
Numerical study on aerodynamic performance of waverider with a new bluntness method
Authors: Qu Zhipeng , Xiao Houdi , Lv Mingyun , Li Guangli , Kai Cui 
Published: October 2020

Abastrct The waverider is deemed the most promising configuration for hypersonic vehicle with its high lift-to-drag ratio at design conditions. However, considering the serious aero-heating protection, the sharp leading edge must be blunted. The existing traditional bluntness methods including the following two types: “reducing material method” and “adding material method”. Compared to the initial waverider, the volume will be smaller or larger using the traditional methods. With the fixed blunted radius, the volume and aerodynamic performance is determined. In this paper, a new bluntness method which is named “mixing material method” is developed. In this new method, a new parameter is introduced based on the traditional two bluntness methods. Under fixed blunted radius, the volume and aerodynamic performance can be changed within a wide range by adjusting the parameter. When the parameter is 0 and 1, the novel blunted method degenerated into the “reducing material method” and “adding material method” respectively. The influence of new parameter on the aerodynamic characteristics and volume are studied by numerical simulation. Results show that the volume, lift and lift-to-drag ratio increases with the increase of the parameter under the fixed blunt radius, but simultaneously, the drag will also increase. Therefore, considering the different requirements of the air-breathing hypersonic aircrafts for the balance of thrust and drag, lift and weight, a suitable bluntness parameter can be selected to achieve a balance. This research can provide reference for hypersonic waverider vehicle design.
A Critical Analysis of Capitalism, Capital Accumulation and Crisis Theory in David Harvey
Authors: Majumder Tanaya 
Published: October 2020

This article is a critical review of David Harvey’s essentialist theorisation of a capitalist economy and its crisis from a class focused Marxist perspective. The first part examines Harvey’s immense contribution to the understanding of space and spatiality of capitalism within the Marxist tradition. Capital accumulation in his theorisation serves as the impresario of space and spatiality and the harbinger of capitalist crisis in general. Expanding on a class focused approach, the second part provides a critique of Harvey’s methodology and crisis theory in which the law of capital accumulation reigns supreme. Specifically, using an anti-essentialist methodology of overdetermination with class process of surplus labour as the theoretical entry point, as developed by Resnick and Wolff, I argue that no correspondence of the rate of capital accumulation with those of rate of profit and rate of class distribution can be drawn. This unpredictability renders capitalism inherently unstable, prone to business cycles whose cause cannot be reduced to any chosen causal factor such as the one reducible to capital accumulation. JEL Codes: P12, P16
A Phenomenological Study on New Care Needs of Maslow’s Need-Hierarchy Among Disabled Residents at Nursing Homes in Modern Chinese Society
Authors: Shen Jun , Xiao Lily Dongxia , Liu Yue , Zhang Hong , Wu Lin 
Published: October 2020

Introduction: Meeting the care needs of disabled residents of nursing homes is a vital element to providing high-quality care in modern society. Therefore, this study aimed to explore the disabled residents’ new care needs in nursing homes based on Maslow’s hierarchy of needs theory from their perspectives in modern society. Method: This was a qualitative study. Semi-structured interviews were conducted with a purposeful sample of 23 disabled residents in a nursing home in China. All data were transcribed and coded for emerging themes. Results: A qualitative data analysis generated 4 dimensions and 12 aspects of needs: intelligent technology (including intelligent health management, intelligent life care, and intelligent psychological care), security (including air and food safety, network security, and protecting privacy), participation (including social relations, self-regulated learning, and volunteer service), and spirituality (including religious beliefs needs, maintaining dignity, and self-determination). Discussion: These findings can inform nursing home health care professionals about the new care needs of disabled residents to improve nursing home care protocols to accommodate residents’ expressed needs, thus fostering better care.
Direct Oral Anticoagulants in Select Patients With Hypercoagulable Disorders
Authors: Valanejad Sara M. , Davis Kyle A. 
Published: October 2020

Objective: To summarize the literature assessing the safety and efficacy of direct oral anticoagulants (DOACs) for the acute treatment and secondary prevention of venous thromboembolism (VTE) in select patients with hypercoagulable disorders. Data Sources: An electronic PubMed literature search was conducted from January 2010 to July 2020 using the following keywords: DOAC, rivaroxaban, apixaban, dabigatran, edoxaban, thrombophilia, cancer, antiphospholipid syndrome, protein C deficiency, protein S deficiency, antithrombin deficiency, factor V Leiden, prothrombin G20210A gene mutation, congenital thrombophilia, hypercoagulable, hereditary thrombophilia, acquired thrombophilia. Study Selection and Data Extraction: Articles were included if they reported clinical outcomes associated with cancer-associated VTE, antiphospholipid syndrome (APS), and other hereditary thrombophilias. Data Synthesis: The safety and efficacy of using a DOAC is highly dependent on the type of hypercoagulable disease state. Current trials support the use of edoxaban, rivaroxaban, and apixaban for the treatment of cancer-associated thrombosis (CAT), with apixaban being preferred because of lower bleeding rates compared with standard of care. The use of DOACs, especially rivaroxaban, have been associated with worse outcomes in patients with APS, whereas data on DOAC use in hereditary thrombophilia remains scarce and limited to low-risk patients. Relevance to Patient Care and Clinical Practice: This review evaluates the literature assessing the safety and efficacy of DOACs in patients with various hypercoagulable disorders. Conclusions: The current body of evidence supports the use of select DOACs for the treatment of CAT. In contrast, DOAC use in patients with APS and hereditary thrombophilia should be avoided at this time.