bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemical Solution Route for High‐Quality Multiferroic BiFeO3 Thin Films
Authors: Yang Bingbing , Jin Linghua , Wei Renhuai , Tang Xianwu , Hu Ling , Tong Peng , Yang Jie , Song Wenhai , Dai Jianming , Zhu Xuebin , Sun Yuping , Zhang Shujun , Wang Xiaolin , Cheng Zhenxiang 
Published: November 2019

AbstractBismuth ferrite (BiFeO3) has recently become interesting as a room‐temperature multiferroic material, and a variety of prototype devices have been designed based on its thin films. A low‐cost and simple processing technique for large‐area and high‐quality BiFeO3 thin films that is compatible with current semiconductor technologies is therefore urgently needed. Development of BiFeO3 thin films is summarized with a specific focus on the chemical solution route. By a systematic analysis of the recent progress in chemical‐route‐derived BiFeO3 thin films, the challenges of these films are highlighted. An all‐solution chemical‐solution deposition (AS‐CSD) for BiFeO3 thin films with different orientation epitaxial on various oxide bottom electrodes is introduced and a comprehensive study of the growth, structure, and ferroelectric properties of these films is provided. A facile low‐cost route to prepare large‐area high‐quality epitaxial BFO thin films with a comprehensive understanding of the film thickness, stoichiometry, crystal orientation, ferroelectric properties, and bottom electrode effects on evolutions of microstructures is provided. This work paves the way for the fabrication of devices based on BiFeO3 thin films.
Domain‐specific visualization system based on automatic multiseed recommendations: Extracting stratigraphic structures
Authors: Liu Richen , Ji Genlin , Su Mingjun 
Published: November 2019

SummaryUnderground flow path (UFP) is one of the most significant stratigraphic structures in revealing the distribution of oil or gas from seismic data. We design a domain‐specific visualization system to extract the stratigraphic structures by seed point tracing and explore the seismic data by graph interactions. The seeds are automatically generated by kernel function–based density gradients computation. Users are allowed to adjust the recommended seeds by fine‐tuning them with visual interactions. The seeds are further merged by a weighted quick‐union algorithm to get the link information to construct a graph. Different types of nodes in the graph are designed to enable users to explore the extracted UFP structures intuitively. Finally, we evaluated the proposed approach by performance tests, sensitivity tests, and ground truth tests. The feedback from the domain experts demonstrates that the proposed visualization tool improved the capability of revealing the distribution and geostructures of UFPs compared with the existing methods.
Recent advancements in understanding fin regeneration in zebrafish
Authors: Sehring Ivonne M. , Weidinger Gilbert 
Published: November 2019

AbstractZebrafish have the remarkable ability to fully regenerate a lost appendage, faithfully restoring its size, shape and tissue patterning. Studies over the past decades have identified mechanisms underlying the formation, spatial organization, and regenerative growth of the blastema, a pool of proliferative progenitor cells. The patterning of newly forming tissue is tightly regulated to ensure proper rebuilding of anatomy. Precise niche regulation of retinoic acid and sonic hedgehog signaling ensures adherence to ray—interray boundaries. The molecular underpinnings of systems underlying re‐establishment of pre‐amputation size and shape (positional information) are also slowly starting to emerge. Osteoblasts play an important role as a cellular source of regenerating skeletal elements, and in zebrafish both osteoblast dedifferentiation as well as de novo osteoblast formation occurs. Both dedifferentiation and proliferation are tightly controlled, which makes it interesting to compare it to tumorigenesis, and to identify potential players involved in these processes.This article is categorized under:

Adult Stem Cells, Tissue Renewal, and Regeneration > Regeneration
Heavy black hole effective theory
Authors: Damgaard Poul H. , Haddad Kays , Helset Andreas 
Published: November 2019

Abstract
We formulate an effective field theory describing large mass scalars and fermions minimally coupled to gravity. The operators of this effective field theory are organized in powers of the transfer momentum divided by the mass of the matter field, an expansion which lends itself to the efficient extraction of classical contributions from loop amplitudes in both the post-Newtonian and post-Minkowskian regimes. We use this effective field theory to calculate the classical and leading quantum gravitational scattering amplitude of two heavy spin-1/2 particles at the second post-Minkowskian order.
Relating non-relativistic string theories
Authors: Harmark Troels , Hartong Jelle , Menculini Lorenzo , Obers Niels A. , Oling Gerben 
Published: November 2019

Abstract
Non-relativistic string theories promise to provide simpler theories of quantum gravity as well as tractable limits of the AdS/CFT correspondence. However, several apparently distinct non-relativistic string theories have been constructed. In particular, one approach is to reduce a relativistic string along a null isometry in target space. Another method is to perform an appropriate large speed of light expansion of a relativistic string. Both of the resulting non-relativistic string theories only have a well-defined spectrum if they have nonzero winding along a longitudinal spatial direction. In the presence of a Kalb-Ramond field, we show that these theories are equivalent provided the latter direction is an isometry. Finally, we consider a further limit of non-relativistic string theory that has proven useful in the context of AdS/CFT (related to Spin Matrix Theory). In that case, the worldsheet theory itself becomes non-relativistic and the dilaton coupling vanishes.
From 3d dualities to 2d free field correlators and back
Authors: Pasquetti Sara , Sacchi Matteo 
Published: November 2019

Abstract
We investigate the relation between 3d$$ \mathcal{N} $$
N
= 2 theories and 2d free field correlators or Dotsenko-Fateev (DF) integrals for Liouville CFT. We show that the S2× S1 partition functions of some known 3d Seiberg-like dualities reduce, in a suitable 2d limit, to known basic duality identities for DF correlators. These identities are applied in a variety of contexts in CFT, as for example in the derivation of the DOZZ 3-point function. Reversing the logic, we can try to guess new 3d IR dualities which reduce to more intricate duality relations for the DF correlators. For example, we show that a recently proposed duality relating the U(N) theory with one flavor and one adjoint to a WZ model can be regarded as the 3d ancestor of the evaluation formula for the DF integral representation of the 3-point correlator. We are also able to interpret the analytic continuation in the number of screening charges, which is performed on the CFT side to reconstruct the DOZZ 3-point function, as the geometric transition relating the 3d U(N) theory to the 5d T2 theory.
The gut microbiome in tuberculosis susceptibility and treatment response: guilty or not guilty?
Authors: Eribo Osagie A. , du Plessis Nelita , Ozturk Mumin , Guler Reto , Walzl Gerhard , Chegou Novel N. 
Published: November 2019

AbstractAlthough tuberculosis (TB) is a curable disease, it remains the foremost cause of death from a single pathogen. Globally, approximately 1.6 million people died of TB in 2017. Many predisposing factors related to host immunity, genetics and the environment have been linked to TB. However, recent evidence suggests a relationship between dysbiosis in the gut microbiome and TB disease development. The underlying mechanism(s) whereby dysbiosis in the gut microbiota may impact the different stages in TB disease progression, are, however, not fully explained. In the wake of recently emerging literature, the gut microbiome could represent a potential modifiable host factor to improve TB immunity and treatment response. Herein, we summarize early data detailing (1) possible association between gut microbiome dysbiosis and TB (2) the potential for the use of microbiota biosignatures to discriminate active TB disease from healthy individuals (3) the adverse effect of protracted anti-TB antibiotics treatment on gut microbiota balance, and possible link to increased susceptibility to Mycobacterium tuberculosis re-infection or TB recrudescence following successful cure. We also discuss immune pathways whereby the gut microbiome could impact TB disease and serve as target for clinical manipulation.
Fluctuations in Ballistic Transport from Euler Hydrodynamics
Authors: Doyon Benjamin , Myers Jason 
Published: November 2019

AbstractWe propose a general formalism, within large-deviation theory, giving access to the exact statistics of fluctuations of ballistically transported conserved quantities in homogeneous, stationary states. The formalism is expected to apply to any system with an Euler hydrodynamic description, classical or quantum, integrable or not, in or out of equilibrium. We express the exact scaled cumulant generating function (or full counting statistics) for any (quasi-)local conserved quantity in terms of the flux Jacobian. We show that the “extended fluctuation relations” of Bernard and Doyon follow from the linearity of the hydrodynamic equations, forming a marker of “freeness” much like the absence of hydrodynamic diffusion does. We show how an extension of the formalism gives exact exponential behaviours of spatio-temporal two-point functions of twist fields, with applications to order-parameter dynamical correlations in arbitrary homogeneous, stationary state. We explain in what situations the large-deviation principle at the basis of the results fail, and discuss how this connects with nonlinear fluctuating hydrodynamics. Applying the formalism to conformal hydrodynamics, we evaluate the exact cumulants of energy transport in quantum critical systems of arbitrary dimension at low but nonzero temperatures, observing a phase transition for Lorentz boosts at the sound velocity.
Capability of Tokai Strainmeter Network to Detect and Locate a Slow Slip: First Results
Authors: Nanjo K. Z. 
Published: November 2019

AbstractThe Tokai Strainmeter Network (TSN), a dense network deployed in the Tokai region, which is the easternmost region of the Nankai trough, has been designed to monitor slow slips that reflect changes in the coupling state of the plate boundary. It is important to evaluate the current capability of TSN to detect and locate slow slips. For this purpose, the probability-based magnitude of completeness developed for seismic networks was modified to be applicable to the evaluation of TSN’s performance. Using 35 slow slips having moment magnitudesM5.1–5.8 recorded by TSN in 2012–2016, this study shows that the probability that TSN detected and located aM5-class slow slip is high (> 0.9) when considering a region in and around the TSN. The probability has been found to depend on the slip duration, especially forM5.5 or larger, namely the longer the duration, the lower the probability. A possible use of this method to assess the network’s performance for cases where virtual stations are added to the existing network was explored. The use of this application when devising a strategic plan of the TSN to extend its coverage westwards is proposed. This extension that allows TSN to cover the entire eastern half of the Nankai trough is important, because the historical records show that the eastern half of this trough tends to rupture first.
Topological stable rank of $$\mathcal {E}'(\mathbb {R})$$
Authors: Sasane Amol 
Published: November 2019

AbstractThe set $$\mathcal {E}'(\mathbb {R})$$

E

′

(
R
)

of all compactly supported distributions, with the operations of addition, convolution, multiplication by complex scalars, and with the strong dual topology is a topological algebra. In this article, it is shown that the topological stable rank of $$\mathcal {E}'(\mathbb {R})$$

E

′

(
R
)

is 2.
In vivo characterization of [18F]AVT-011 as a radiotracer for PET imaging of multidrug resistance
Authors: Kannan Pavitra , Füredi András , Dizdarevic Sabina , Wanek Thomas , Mairinger Severin , Collins Jeffrey , Falls Theresa , van Dam R. Michael , Maheshwari Divya , Lee Jason T. , Szakács Gergely , Langer Oliver 
Published: November 2019

Abstract
Purpose
Multidrug resistance (MDR) impedes cancer treatment. Two efflux transporters from the ATP-binding cassette (ABC) family, ABCB1 and ABCG2, may contribute to MDR by restricting the entry of therapeutic drugs into tumor cells. Although a higher expression of these transporters has been correlated with an unfavorable response to chemotherapy, transporter expression does not necessarily correlate with function. In this study, we characterized the pharmacological properties of [18F]AVT-011, a new PET radiotracer for imaging transporter-mediated MDR in tumors.

Methods
AVT-011 was radiolabeled with 18F and evaluated with PET imaging in preclinical models. Transport of [18F]AVT-011 by ABCB1 and/or ABCG2 was assessed by measuring its uptake in the brains of wild-type, Abcb1a/b−/−, and Abcg2−/− mice at baseline and after administration of the ABCB1 inhibitor tariquidar (n = 5/group). Metabolism and biodistribution of [18F]AVT-011 were also measured. To measure ABCB1 function in tumors, we performed PET experiments using both [18F]AVT-011 and [18F]FDG in mice bearing orthotopic breast tumors (n = 7–10/group) expressing clinically relevant levels of ABCB1.

Results
At baseline, brain uptake was highest in Abcb1a/b−/− mice. After tariquidar administration, brain uptake increased 3-fold and 8-fold in wild-type and Abcg2−/− mice, respectively, but did not increase further in Abcb1a/b−/− mice. At 30 min after injection, the radiotracer was > 90% in its parent form and had highest uptake in organs of the hepatobiliary system. Compared with that in drug-sensitive tumors, uptake of [18F]AVT-011 was 32% lower in doxorubicin-resistant tumors with highest ABCB1 expression and increased by 40% with tariquidar administration. Tumor uptake of [18F]FDG did not significantly differ among groups.

Conclusion
[18F]AVT-011 is a dual ABCB1/ABCG2 substrate radiotracer that can quantify transporter function at the blood-brain barrier and in ABCB1-expressing tumors, making it potentially suitable for clinical imaging of ABCB1-mediated MDR in tumors.
Effects of a multispecies synbiotic on glucose metabolism, lipid marker, gut microbiome composition, gut permeability, and quality of life in diabesity: a randomized, double-blind, placebo-controlled pilot study
Authors: Horvath Angela , Leber Bettina , Feldbacher Nicole , Tripolt Norbert , Rainer Florian , Blesl Andreas , Trieb Markus , Marsche Gunther , Sourij Harald , Stadlbauer Vanessa 
Published: November 2019

AbstractPurposeDiabesity, the combination of obesity and type 2 diabetes, is an ever-growing global health burden. Diabesity-associated dysbiosis of the intestinal microbiome has gained attention as a potential driver of disease and, therefore, a possible therapeutic target by means of pro- or prebiotic supplementation. This study tested the effects of a multispecies synbiotic (i.e. a combination of probiotics and prebiotics) on glucose metabolism, gut microbiota, gut permeability, neutrophil function and quality of life in treatment-experienced diabesity patients.MethodsA randomized, double-blind, placebo-controlled pilot study with 26 diabesity patients was conducted in which patients received a daily dose of a multispecies probiotic and a prebiotic (or a placebo) for 6 months.ResultsThere were no changes in glucose metabolism or mixed meal tolerance test responses throughout the study. The analysis of secondary outcomes revealed beneficial effects on hip circumference [− 1 (95% CI − 4; 3) vs +3 (− 1; 8) cm, synbiotics vs. placebo, respectively,p = 0.04], serum zonulin [− 0.04 (− 0.2; 0.1) vs +0.3 (− 0.05; 0.6) ng/ml,p = 0.004)] and the physical role item of the SF36 quality of life assessment [+ 5.4 (− 1.7; 12.5) vs − 5.0 (− 10.1; 0.2) points,p = 0.02] after 3 months of intervention, and lipoprotein (a) [− 2.1 (− 5.7; 1.6) vs +3.4 (− 0.9; 7.9) mg/dl,p = 0.02] after 6 months. There were no significant differences in alpha or beta diversity of the microbiome between groups or time points.ConclusionsGlucose metabolism as the primary outcome was unchanged during the intervention with a multispecies synbiotic in patients with diabesity. Nevertheless, synbiotics improved some symptoms and biomarkers of type 2 diabetes and aspects of quality of life suggesting a potential role as adjuvant tool in the management of diabesity.Graphic abstract
Dietary intake of total polyphenols and the risk of all-cause and specific-cause mortality in Japanese adults: the Takayama study
Authors: Taguchi Chie , Kishimoto Yoshimi , Fukushima Yoichi , Kondo Kazuo , Yamakawa Michiyo , Wada Keiko , Nagata Chisato 
Published: November 2019

Abstract
Purpose
Several epidemiological studies have demonstrated the health benefits of polyphenols, but the associations between polyphenol intake and mortality including total and major causes of death remain unclear. We investigated the associations between subjects’ total polyphenol intake and their mortality from all causes, cardiovascular disease (CVD), cancer, and other causes of death in a population-based cohort study in Japan.

Methods
A total of 29,079 residents of Takayama City, Japan were analyzed. Their dietary intake was assessed using a validated semi-quantitative food-frequency questionnaire (FFQ) in 1992. Mortality was ascertained over the subsequent 16 years. The dietary polyphenol intake was calculated by matching the subjects’ food consumption data with our original polyphenol content database.

Results
A total of 5339 deaths occurred during the follow-up. After multivariable adjustment, the highest quartile of total polyphenol intake compared with the lowest quartile was significantly associated with a lower risk of all-cause mortality (HR: 0.93, 95% CI: 0.82–0.99, p trend = 0.003). The subjects in the highest quartile showed significantly lower CVD mortality compared to those in the lowest quartile, and among the types of CVD mortality, a strong inverse association was observed for stroke mortality. Inverse associations were also observed for mortality from other causes, specifically digestive disease. The total polyphenol intake was not significantly associated with the risk of cancer mortality.

Conclusions
The results of this prospective study indicate that dietary total polyphenol intake in Japanese is inversely associated with all-cause mortality and mortality from cardiovascular and digestive diseases.
A single dose of purple grape juice improves physical performance and antioxidant activity in runners: a randomized, crossover, double-blind, placebo study
Authors: de Lima Tavares Toscano Lydiane , Silva Alexandre Sérgio , de França Ana Carla Lima , de Sousa Bruno Rafael Virgínio , de Almeida Filho Eder Jackson Bezerra , da Silveira Costa Matheus , Marques Aline Telles Biasoto , da Silva Darcilene Fiuza , de Farias Sena Klécia , Cerqueira Gilberto Santos , da Conceição Rodrigues Gonçalves Maria 
Published: November 2019

AbstractPurposeTo investigate the effects of a single dose of juice on physical performance, oxidative stress, inflammation and muscle damage in runners.MethodsFourteen recreational male runners (39 ± 9 years,VO2peak = 55.9 ± 6.5 ml/kg/min) performed two running tests to exhaustion at 80% ofVO2maxafter ingesting grape juice or a placebo drink (10 ml/kg/day) randomly. Blood samples were taken before and 2 h after supplementation and immediately after running to analyze total antioxidant capacity (TAC), malondialdehyde (MDA), alpha-1 acid glycoprotein (A1GPA), high-sensitivity C-reactive protein (hs-CRP), creatine kinase (CK) and lactate dehydrogenase (LDH).ResultsThe participants ran for an average of 59.2 ± 27.8 min until exhaustion in the placebo group and for 68.4 ± 29.7 min until exhaustion in the grape juice intake group, which was a significantly longer time (p = 0.008). This improvement in physical performance was accompanied by a 43.6% increase in TAC (p = 0.000) at the post-exercise timepoint compared to the level at baseline. MDA, A1GPA, hs-CRP, CK, and LDH did not exhibit changes. In contrast, no significant change in any variable was observed after consuming the placebo drink.ConclusionThe single-dose intake of purple grape juice demonstrated an ergogenic effect in recreational runners by increasing run time to exhaustion and increasing antioxidant activity.
Predicting recurrences of macular edema due to branch retinal vein occlusion during anti-vascular endothelial growth factor therapy
Authors: Suzuki Misa , Nagai Norihiro , Minami Sakiko , Kurihara Toshihide , Kamoshita Mamoru , Sonobe Hideki , Watanabe Kazuhiro , Shinoda Hajime , Tsubota Kazuo , Ozawa Yoko 
Published: November 2019

Abstract
Purpose
To determine the predictive factors for recurrent macular edema due to branch retinal vein occlusion (BRVO) during intravitreal ranibizumab (IVR) monotherapy.

Methods
Clinical records were retrospectively reviewed for 65 patients (mean age 66.5 years, 65 eyes) who were diagnosed with macular edema due to BRVO and treated with IVR monotherapy for 12 months at the Medical Retina Division, Department of Ophthalmology, Keio University Hospital between October 2013 and August 2017. Best-corrected visual acuity (BCVA), fundus findings, and sectional optical coherence tomography (OCT) images were analyzed.

Results
Overall BCVA and central retinal thickness (CRT) improved (all p < 0.01). BCVA at 12 months was significantly worse in patients with recurrent macular edema (40 eyes [61.5%]) (p < 0.01) than in those without, while CRT decreased and was comparable in both groups at 12 months. Logistic regression analyses showed association of recurrence with disorganization of the retinal inner layer (DRIL) temporal to the fovea at baseline (odds ratio = 7.74; 95% confidence interval 1.62–37.08, p = 0.01), after adjusting for age, gender, and initial CRT.

Conclusion
Recurrent macular edema due to BRVO affects visual outcome and is associated with initial DRIL temporal to the fovea, evaluated using OCT sectional images before treatments. DRIL may facilitate determination of follow-up schedules in clinical practice.