bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic value of neutrophil-lymphocyte ratio in preeclampsia
Authors: Zheng Wen-Fei , Zhan Jingqiong , Chen Aihua , Ma Huigai , Yang Huaijie , Maharjan Rashmisha 
Published: December 2019

Abstract

Background:
Neutrophil-lymphocyte ratio (NLR) is one of the markers of systemic inflammation. Recent studies have associated NLR with diagnosis of preeclampsia (PE). However, due to small sample sizes and different research design, the diagnostic value of NLR in PE patients is not well understood. In this study, we evaluate the potential diagnostic value of NLR in PE.

Methods:
We searched PubMed, Embase, Cochrane Library, the Chinese National Knowledge Infrastructure (CNKI) databases, Wanfang data, VIP database and China Biomedical Literature Database systematically for relevant literatures up to May 20, 2018. All analyses were conducted using Meta-DiSc1.4 and Stata 12.0 software. Sensitivity, specificity and other measures of accuracy of NLR for the diagnosis of PE were pooled. Meta-regression was performed to identify the sources of heterogeneity.

Results:
This meta-analysis included a total of 7 studies. The pooled sensitivity and specificity were 0.74 (95% CI 0.71–0.76) and 0.64 (95%CI 0.61–0.68), positive likelihood ratio, 2.62 (95%CI1.79–3.84); negative likelihood ratio, 0.34 (95%CI 0.24–0.48); diagnostic odds ratio, 8.44 (95%CI 4–17.78), and area under the curve was 0.82. Meta regression showed that sample size was the main source of heterogeneity. Deeks funnel plot showed that there was no statistical significance for the evaluation of publication bias (P = .16).

Conclusion:
Current evidence suggests that the diagnostic accuracy of NLR has unsatisfactory specificity but acceptable sensitivity for diagnosis of PE. Further large-scale prospective studies are required to validate the potential applicability of using NLR alone or in combination other markers as PE diagnostic biomarker and explore potential factors that may influence the accuracy of NLR for PE diagnosis.
Liposomal Irinotecan + 5-FU/LV in Metastatic Pancreatic Cancer
Authors: Macarulla Mercadé Teresa , Chen Li-Tzong , Li Chung-Pin , Siveke Jens T. , Cunningham David , Bodoky György , Blanc Jean-Frédéric , Lee Kyung-Hun , Dean Andrew , Belanger Bruce , Wang-Gillam Andrea 
Published: December 2019

Objectives
The NAnoliPOsomaL Irinotecan (NAPOLI-1) study (NCT01494506) was the largest global phase 3 study in a post-gemcitabine metastatic pancreatic adenocarcinoma (mPAC) population (N = 417). The subanalyses reported here investigated the prognostic effect of tumor characteristics and disease stage, prior treatment characteristics, baseline patient characteristics on survival outcomes in NAPOLI-1, and whether liposomal irinotecan (nal-IRI) + 5-fluorouracil/leucovorin (5-FU/LV) benefited patients with mPAC across subgroups.

Methods
Post hoc analyses were performed in the NAPOLI-1 population (4 across tumor characteristics and disease stage, 6 across prior treatment characteristics, and 4 across patient baseline characteristics). Survival outcomes were estimated by Kaplan-Meier analysis and patient safety data were evaluated.

Results
Mortality and morbidity risk was lower on nal-IRI+5-FU/LV treatment across subgroups. Exceptions were patients who had received prior nonliposomal irinotecan and those who had undergone prior Whipple procedure (overall survival hazard ratio = 1.25 and 1.23, respectively). Decreased appetite, liver metastases, and number of measurable metastatic lesions seemed to be prognostic of survival in this population. Subgroup safety data were generally comparable with those in the overall NAPOLI-1 safety population.

Conclusions
A diverse population of patients with mPAC that progressed on gemcitabine-based therapy benefited from nal-IRI+5-FU/LV versus 5-FU/LV, potentially helping guide treatment decisions for challenging cases.
Primary and Metastatic Pancreatic Cancer Cells Exhibit Differential Migratory Potentials
Authors: Park Joo Kyung , Hank Thomas , Scherber Cally M. , Lillemoe Keith D. , Fernández-del Castillo Carlos , Warshaw Andrew L. , Toner Mehmet , Irimia Daniel , Thayer Sarah P. , Liss Andrew S. 
Published: December 2019

Objectives
Pancreatic ductal adenocarcinoma (PDAC) is characterized by early metastatic spread in more than 50% of patients. In this study, we sought to understand the migratory properties of (non)metastatic PDAC cells and determine whether the migration of cancer stem cell (CSC) populations accounts for the aggressive nature of this disease.

Methods
The migratory abilities of primary and metastatic PDAC cell lines were investigated using a microfluidic device and time-lapse photography. The velocity, time of delay of mobilization, and number of migratory cells were analyzed. Cancer stem cell subpopulations were isolated by fluorescence-activated cell sorting and their migratory properties compared with their non-CSC counterparts.

Results
Primary cancer cells exhibited higher velocities, greater number of migratory cells, and a shorter time of delay of mobilization in comparison to metastatic cell lines. Characterization of CSC populations revealed primary PDAC cell lines were composed of fewer CD133+ and CD24+CD44+ CSC subpopulations than metastatic cells. Moreover, migratory analysis of CSC subpopulations revealed lower velocities, fewer migratory cells, and a greater time of delay of mobilization than non-CSC.

Conclusions
Primary cancer cells demonstrate enhanced migratory abilities in comparison to metastatic PDAC cells. Those differences may result from lower CSC subpopulations in primary cells because CSC populations demonstrated impaired migratory abilities in contrast to non-CSC.
Reducing Medication Error Through a Collaborative Committee Structure: An Effort to Implement Change in a Community-Based Health System
Authors: Hanifin Rikki , Zielenski Christopher 
Published: December 2019

Objectives:
This article describes a methodology for implementation and sustainment of continuous quality improvement initiatives through committee structures aimed at reducing medication error rates.

Methods:
A committee structure was developed in a collaborative effort to analyze and reduce medication error rates. Interdisciplinary teams comprised of frontline staff met regularly to identify and resolve trending medication safety events and prepare and deliver education for staff. Continuous quality improvement initiatives supported by these committees included technical handling and administration of medication, medication reconciliation, and enhancements to standardized treatment protocols. Data were collected through a voluntary electronic safety event reporting system between March 2013 and March 2016, to evaluate the rate of medication errors and near-misses.

Results:
A retrospective analysis of reported medication errors and near-misses was conducted. The medication error rate significantly declined over the study period as the rate of near-misses conversely increased.

Conclusions:
Initiatives supported by the oversight of collaborative committees were successful in decreasing medication error rates.
Assessment of the Relationship Between the Coronary Venous and Arterial Systems Using 256-Slice Computed Tomography
Authors: Bai Wei , Xu Xiao , Ma Heng , Zhong Lin , Xie Haizhu , Sun Chunjuan , Shi Yinghong , Che Kaili , Liu Meijie , Yang Jun 
Published: December 2019

ObjectivesTo investigate the coronary venous system (CVS) and its spatial relationship with coronary arteries by using 256-slice computed tomography (CT).MethodsOne hundred one patients underwent coronary CT angiography by using a 256-slice CT. In each patient, the CVS and its spatial relationship with coronary arteries were analyzed. We measured the diameters and angulations of the coronary sinus (CS), great cardiac vein, anterior interventricular vein (AIV), left marginal vein, posterior vein of the left ventricle (PVLV), and posterior interventricular vein (PIV), and the distances, respectively, from the CS ostium and from the crossing point to the ostium of corresponding tributaries.ResultsThe following 5 pairs of veins and arteries had a higher frequency of intersecting compared with others: the CS/great cardiac vein and the left circumflex coronary artery (97.1%), the AIV and the diagonal or ramus branch (92.1%), the PIV and the posterior branch of left ventricle artery (88.1%), the left marginal vein and the circumflex or circumflex marginal (73.9%), and the PVLV and the circumflex or circumflex marginal (31.6%). The other 2 pairs had a higher frequency of running parallel to each other: the AIV and the left anterior descending artery (76.2%) and the PIV and the posterior descending artery (54.4%). Most tributaries were lateral to their corresponding arteries at the crossing point except for the AIV. For the PVLV and PIV, the distances from the crossing point to the ostium of corresponding veins when the veins were lateral to the arteries were smaller than those when the veins were medial to the arteries (P< 0.05).ConclusionsThe CVS and its anatomical relationship with the coronary arterial system can be examined with details by using a 256-slice CT, which has important clinical implications.
Two Laterally Based Flap Otoplasty for Protruding Ear Correction
Authors: Ersen Burak 
Published: December 2019

The postauricular fascial flap as supportive or stand-alone technique provides natural, symmetrical-looking ears with minimal complications and recurrence. However, the posterior fascial flap otoplasty is not applicable for all protruding ear deformity types. It is particularly advantageous in terms of anti-helix creation yet does not have a satisfactory effect for correction of conchal hypertrophy. In this paper, it was aimed to describe a new technique, solely focuses on overcoming the conchal hypertrophy problem during protruding ear repair.
A total of 12 patients (8 male and 4 female) underwent otoplasty with the same surgeon between May 2017 and May 2018. All otoplasties were performed bilaterally. Patients with conchal hypertrophy and anti-helical effacement were included into this study to evaluate the efficiency of the new technique.
A total of 12 patients (8 male and 4 female) underwent otoplasty with described technique. Patients ages ranged from 18 to 30 years, with a median of 27.6 years. None of the patients suffered from early postoperative complications, such as skin necrosis, suture extrusion, hematoma, or wound infection. There was only 1 patient with the complaint of asymmetry at the late postoperative period and unilateral revision otoplasty was performed.
In this study it was aimed to demonstrate a new technique which contains one posterior perichondrio-adipo-dermal flap and 1 perichondreal flap. The technique is highly advantageous if the patient suffers from both conchal hypertrophy and anti-helical effacement. It was seen that the described technique is practical and efficient for patients who both has conchal hypertrophy and anti-helical effacement.

Level of Evidence:
III, therapeutic study.
Pre-Expanded Latissimus Dorsi Myocutaneous Flap for Total Scalp Defect Reconstruction
Authors: Xiao Yang , Xiao Haitao , Wan Haifeng , Zeng Qian , Zhang Yange , Xu Xuewen 
Published: December 2019

Abstract
Scalp defects can be caused by various factors, and reconstruction options for scalp defects include skin grafts, local flaps, tissue expanders, and free flaps. However, currently, it is widely accepted that the use of free flaps is the most feasible method for extensive scalp defect reconstruction. While multiple flaps have been used to reconstruct scalp defects, the reconstruction of total scalp defects still remains challenging. Pre-expansion of free flaps offers several advantages, including increasing flap size and thinning of the tissue for better contour, and is particularly important in scalp reconstruction. This report describes the successful management of total scalp defect reconstruction that involved the entire frontal, parietal, occipital, and temporal regions using a pre-expanded latissimus dorsi myocutaneous flap in a 40-year-old female patient. Over 2 years of follow-up, the transplanted flap survived well and the patient eventually achieved excellent cosmetic appearance, with satisfactory durable coverage. She was able to wear a hairpiece and hat without any wound breakdown. Our report indicates that microsurgery using pre-expanded latissimus dorsi myocutaneous flap transfer is a reliable and safe choice for total scalp reconstruction, allowing reconstruction with a single-flap, an excellent aesthetic effect, and abrasive resistance.
Strategy for the Treatment of Zygomatic-Coronoid Ankylosis
Authors: Santos Anderson Maikon de Souza , Mendes Bruno Coelho , Lima-Neto Tiburtino José de , Paiva Marcos Antônio Farias de , Villarim Natália Lins de Souza , Santos Murilo Quintão dos , Faverani Leonardo Perez , Hochuli-Vieira Eduardo 
Published: December 2019

Abstract
Zygomatic-coronoid ankylosis is a rare complication in maxillofacial trauma. Currently, less of 30 cases reported in the literature. The aim of this study was to report a case of zygomatic-coronoid ankylosis after trauma. A 26-year-old male, with zygomatic-coronoid ankylosis after 7 years of facial trauma, was treated by intraoral bilateral coronoidectomy. However, the literature continues to discuss the best approach, intraorally or extraorally. This study observed that the intraoral approach was easily performed and without complications.
Bio-DIA: A web-based tool for data and algorithms integration
Authors: Dantas Thiago , da Silva Vandeclécio Lira , Fonseca André Faustino , Morais Diego A A , Signoretti Alberto , Blanco Wilfredo 
Published: December 2019

AbstractData science is historically a complex field, not only because of the huge amount of data and its variety of formats, but also because the necessity of collaboration between several specialists to retrieve valuable information. In this context, we created Bio-DIA, an online software to build data science workflow process focused in the integration of data and algorithms. Bio-DIA also facilitates the reusability of information/results obtained in previous process without the need of specific skills from the computer science field. The software was created with Angular at the front-end, Django at the back-end together with Spark to handle and process a variety of big data formats. The workflow/project is specified through XML file. Bio-DIA application facilitated the collaboration among users, allowing researcher’s groups to share data, scripts and information.Availabilityhttps://ucrania.imd.ufrn.br/biodia-app/. Login: bioguest, password: welcome123.
Educational attainment reduces the risk of suicide attempt among individuals with and without psychiatric disorders independent of cognition: a multivariable Mendelian randomization study with more than 815,000 participants
Authors: Rosoff Daniel B. , Kaminsky Zachary A. , Lohoff Falk W. 
Published: December 2019

ABSTRACTBackgroundRates of suicidal ideation, attempts and completions are increasing and identifying causal risk factors continues to be a public health priority. Observational literature has shown that educational attainment (EA) and cognitive performance (CP) can influence suicide attempt risk; however, due to residual confounding and reverse causation, the causal nature of these relationships is unknown.MethodsWe perform a multivariable two-sample Mendelian randomization (MR) analysis to disentangle the effects of EA and CP on suicide attempt risk. We use summary statistics from recent genome-wide association studies (GWAS) of EA, CP, household income versus suicide attempt risk in individuals with and without mental disorders, with more than 815,000 combined study participants.ResultsWe found evidence that both EA and CP significantly reduced the risk of suicide attempt when considered separately in single variable MR (SVMR) (Model 1 EA odds ratio (OR), 0.524, 95% CI, 0.412-0.666,P= 1.07⨯10−7; CP OR, 0.714, 95% CI, 0.577-0.885,P= 0.002). When simultaneously analyzing EA,CA, and adjusting for household income but not comorbid mental disorders (Model 1), we found evidence that the direct effect of EA, independent of CP, on suicide attempt risk was greater than the total effect estimated by SVMR, with EA, independent of CP, significantly reducing the risk of suicide attempt by almost 66% (95% CI, 43%-79%); however, the effect of CP was no longer significant independent of EA (Model 1 EA OR, 0.342, 95% CI, 0.206-0.568,P= 1.61×10−4; CP OR, 1.182, 95% CI, 0.842-1.659,P= 0.333). Further, when accounting for comorbid mental disorders (Model 2), these results did not significantly change: we found EA significantly reduced the risk of suicide attempt by 55% (35%-68%), a lower point estimate but still within the 95% confidence interval of Model 1; the effect of CP was still not significant (Model 2 EA OR, 0.450, 95% CI, 0.314-0.644,P< 1.00×10−4; CP OR, 1.143, 95% CI, 0.803-1.627,P= 0.475).ConclusionsOur results show that even after accounting for comorbid mental disorders and adjusting for household income, EA, but not CP, is a causal risk factor in suicide attempt. These findings could have important implications for health policy and prevention programs aimed at reducing the increasing rates of suicide.
A robust gene expression signature to predict proteasome inhibitor benefit in Multiple Myeloma
Authors: Ubels Joske , Sonneveld Pieter , van Vliet Martin H. , de Ridder Jeroen 
Published: December 2019

AbstractMany cancer drugs only benefit a subset of the patients that receive them, but are often associated with serious side effects. Predictive classification methods that can identify which patients will benefit from a specific treatment are therefore of great clinical utility. We here introduce a novel machine learning method to identify predictive gene expression signatures, based on the idea that patients who received different treatments but exhibit similar expression profiles can be used to model response to the alternative treatment. We use this method to predict proteasome inhibitor benefit in Multiple Myeloma (MM). In a dataset of 910 MM patients we identify a 14-gene expression signature that can successfully predict benefit to the proteasome inhibitor bortezomib, with a hazard ratio of 0.47 (p = 0.04) in class ‘benefit’, while in class ‘no benefit’ the hazard ratio is 0.91 (p = 0.68). Importantly, we observe a similar classification performance (HR class benefit = 0.46, p = 0.04) in an independent patient cohort which was moreover measured on a different platform, demonstrating the robustness of the signature. Moreover, we find that the genes in the discovered signature are essential, as no equivalent signature can be found when they are excluded from the analysis. Multiple genes in the signature are linked to working mechanisms of proteasome inhibitors or MM disease progression. In conclusion, our method allows for identification of gene expression signatures that can aid in treatment decisions for MM patients and provide insight into the biological mechanism behind treatment benefit.
Variance and Scale-Free Properties of Resting-State BOLD Signal Alter after Fear Memory Acquisition and Extinction
Authors: Tetereva Alina , Kartashov Sergey , Ivanitsky Alexey , Martynova Olga 
Published: December 2019

AbstractPrevious studies showed differences in brain dynamics during rest and different tasks. We aimed to find changes of variance and scale-free properties of blood oxygenation level-dependent (BOLD) signal between resting-state sessions before and after fear learning and fear memory extinction in twenty-three healthy right-handed volunteers. During a 1-hour break between MRI-scanning, subjects passed through fear extinction procedure, followed by Pavlovian fear conditioning with weak electrical stimulation. After preprocessing, we extracted the average time course of BOLD signal from 245 regions of interest (ROI) taken from the resting-state functional atlas. The variance of the BOLD signal in and Hurst exponent (H), which reflects the scale-free dynamic, were compared in resting states before after fear learning. Six ROIs showed a significant difference in H after fear extinction, including areas from the fear and memory networks. In consistency with the previous results, H decreased during fear extinction but then increased higher than before, specifically in areas related to fear extinction network, whereas the other ROIs restored H to the initial level. The BOLD signal variance showed distinct behavior: the variance in subcortical regions increased permanently, while cortical areas demonstrated a decreasing variance during fear extinction and the reverse growth in resting state after fear extinction. A limited number of ROIs showed both changes in H and the variance. Our results suggest that the variability and scale-free properties of the BOLD signal are sensitive indicators of the residual brain activity related to the recent experience.
Independent Yet Synergistic Roles of Synaptotagmin-1 and Complexin in Calcium Regulated Neuronal Exocytosis
Authors: Ramakrishnan Sathish , Bera Manindra , Coleman Jeff , Rothman James E. , Krishnakumar Shyam S. 
Published: December 2019

ABSTRACTCalcium (Ca2+)-evoked release of neurotransmitters from synaptic vesicles requires mechanisms both to prevent un-initiated fusion of vesicles (clamping) and to trigger fusion following Ca2+-influx. The principal components involved, namely the vesicular fusion machinery (SNARE proteins) and the regulatory proteins (Synaptotagmin-1 and Complexin) are well-known. Here, we use a reconstituted single-vesicle fusion assay to delineate a novel mechanism by which Synaptotagmin-1 and Complexin act independently but synergistically to establish Ca2+-regulated fusion. Under physiologically-relevant conditions, we find that Synaptotagmin-1 oligomers bind and clamp a limited number of ‘central’ SNARE complexes via the primary binding interface, to introduce a kinetic delay in vesicle fusion mediated by the excess of free SNAREpins. This in turn enables Complexin to independently arrest the remaining free ‘peripheral’ SNAREpins to produce stably clamped vesicles. Activation of the central SNAREpins associated with Synaptotagmin-1 by Ca2+is sufficient to trigger rapid (<100 msec) and synchronous fusion of the docked vesicles.