bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multidrug chemotherapy causes early radiological signs of loosening in distal femoral replacements
Authors: Mumith Aadil , Coathup Melanie , Edwards Thomas C , Gikas Panos , Aston Will , Blunn Gordon 
Published: July 2020

Aims Limb salvage in bone tumour patients replaces the bone with massive segmental prostheses where achieving bone integration at the shoulder of the implant through extracortical bone growth has been shown to prevent loosening. This study investigates the effect of multidrug chemotherapy on extracortical bone growth and early radiological signs of aseptic loosening in patients with massive distal femoral prostheses. Methods A retrospective radiological analysis was performed on adult patients with distal femoral arthroplasties. In all, 16 patients were included in the chemotherapy group with 18 patients in the non-chemotherapy control group. Annual radiographs were analyzed for three years postoperatively. Dimensions of the bony pedicle, osseointegration of the hydroxyapatite (HA) collar surface, bone resorption at the implant shoulder, and radiolucent line (RLL) formation around the cemented component were analyzed. Results A greater RLL score (p = 0.041) was observed at three years postoperatively, with those receiving chemotherapy showing greater radiological loosening compared with those not receiving chemotherapy. Chemotherapy patients experience osteolysis at the shoulder of the ingrowth collar over time (p < 0.001) compared with non-chemotherapy patients where osteolysis was not observed. A greater median percentage integration of the collar surface was observed in the non-chemotherapy group (8.6%, interquartile range (IQR) 0.0% to 37.9%; p = 0.021) at three years. Bone growth around the collar was observed in both groups, and no statistical difference in amount of extracortical bony bridging was seen. Conclusion Multidrug chemotherapy affects the osseointegration of ingrowth collars and accelerates signs of radiological loosening. This may increase the risk of aseptic loosening in patients with massive segmental implants used to treat bone cancer. Cite this article: Bone Joint Res 2020;9(7):333–340.
A case series of eight scoliosis patients undergone pedicle screw placement with freehand technique: study for safety and accuracy
Authors: Irianto Komang Agung , Tumbelaka Marquee Kenny 
Published: July 2020

BACKGROUND Pedicle screws and rods are routinely inserted in the vertebrae thoracic to lumbar in scoliosis reconstruction surgery to gain deformity correction and fusion. Intraoperative imaging is often needed to ensure accuracy, but surgical time will be longer and there will be more radiation exposure. Meanwhile, freehand technique is accepted as safe. This study was aimed to evaluate the accuracy of screw insertion in the freehand technique used in adolescent scoliosis surgery.
METHODS This case series evaluated a total of 127 pedicle screws inserted using the freehand technique in 8 out of 28 adolescent scoliosis patients from 2011 to 2016 whom agreed for computed tomography (CT) scan follow-up from 2011 to 2016 in Dr. Seotomo Hospital, Surabaya. The accuracy and safety of the freehand technique were evaluated postoperatively in each patient using a CT scan. A successful screw was considered accurate if it was within the vertebral body and inside the safety zone within the limit of 2–4 mm to the medial or lateral side of the vertebral body.
RESULTS Of the 127 screws inserted, 106 (83.5%) were accurately placed, and 110 (86.6%) were within the safe zone. According to the level of the spine, in the upper and middle thoracic spine, the inserted screws were accurate in 69.4% and 74.9% within the safety zone, whereas in the lower thoracic and lumbar spine, 94.0% and 95.0% within the safety zone.
CONCLUSIONS The freehand technique in scoliosis reconstructive surgery performed by experienced surgeons is accurate and safe.
Neutrophil-to-lymphocyte ratio for predictor of in-hospital mortality in ST-segment elevation myocardial infarction: a meta-analysis
Authors: Mikhael Rodry , Hindoro Evan , Taner Sharleen , Lukito Antonia Anna 
Published: July 2020

BACKGROUND ST-segment elevation myocardial infarction (STEMI) is the most life-threatening condition of acute coronary syndrome that carries a poor prognosis of in-hospital mortality. Multiple scoring systems have been developed to predict in-hospital mortality and other cardiovascular events. Neutrophil-to-lymphocyte ratio (NLR) is hardly used as a predictor of in-hospital mortality. This study was aimed to determine the predictive value of NLR concerning in-hospital mortality in STEMI patients.
METHODS Literature search and pooled analysis related to studies on MEDLINE/PubMed, EBSCO, Science Direct, Cochrane, and ProQuest were retrieved. Inclusion criteria were met if they were cohort studies, the subjects were STEMI patient, contained pretreatment NLR cut-off, and considered in-hospital mortality, which is defined as cardiac or all-cause mortality. Quality assessment was conducted using Newcastle-Ottawa scale. Review Manager version 5.3 (The Nordic Cochrane Centre, Copenhagen) was used for meta-analysis.
RESULTS We found 12 studies with a total of 7,251 STEMI subjects with median NLR cut-off value of 5.6. Elevated NLR on admission carries a high risk of in-hospital mortality (odds ratio [OR] = 3.00, 95% confidence interval [CI] = 2.46–3.67). A slightly higher risk of all-cause mortality (OR = 2.74, 95% CI = 1.99–3.77) was observed compared with cardiac-related mortality (OR = 3.20, 95% CI = 2.47–4.14). No significant heterogeneity was observed between these studies (p = 0.46, I2 = 0%).
CONCLUSIONS Elevated NLR predicts a higher in-hospital mortality rate of STEMI patients.
Causes of mortality in a neonatal intensive care unit in Iran: one year data
Authors: Azami Milad , Jasemi Shamim , Khalifpur Yosef , Badfar Gholamreza 
Published: July 2020

BACKGROUND Neonatal mortality rate is a major health index. Approximately, 65% of all deaths in the first year of life occur during this 4-week period. The present study was conducted to investigate the mortality rates and causes of death in a neonatal intensive care unit (NICU) in Ahvaz, Iran in a year.
METHODS This cross-sectional study was conducted in the NICU of Sina Hospital in Ahvaz. Medical records were studied, and data from 1,040 newborns admitted to the NICU within one year (March 2016 to March 2017) were collected following a checklist. Of these newborns, 123 died, and their relevant data were collected. Data were analyzed using SPSS, version 20 (SPSS Inc., USA).
RESULTS The mortality rate was 11.82% (123 cases) out of 1,040 newborns admitted to NICU. Most of the newborns (48.8%) died on days 1–7. The causes of death were respiratory distress syndrome (RDS) (34.1%), asphyxia (25.2%), anomalies (10.6%), sepsis (7.3%), intracerebral hemorrhage (8.1%), pulmonary hemorrhage (7.3%), and other causes (6.4%), such as hydrops, severe pneumothorax, severe renal failure, and others.
CONCLUSIONS The mortality rate in the NICU of this center was similar to that in other Iranian provinces. The most common causes of NICU mortality included prematurity and its complications, such as asphyxia and RDS. Thus, a strategic plan for reducing preterm delivery and asphyxia are necessary.
MLH1 and MSH2 mismatch repair protein profile using immunohistochemistry in Nepalese colorectal cancer patients
Authors: Bhattarai Matrika , Wan Juhari Wan Khairunnisa , Lama Raju , Pun Chin Bahadur , Yusof Wardah , Wan Abdul Rahman Wan Faiziah , Zakaria Andee Dzulkarnaen , Ahmad Amin Noordin Khairul Bariah , R. Shrestha Tilak , Zilfalil Bin Alwi 
Published: July 2020

BACKGROUND Hereditary nonpolyposis colorectal cancer, or Lynch syndrome, caused by germline mutations or genetic defects in mismatch repair (MMR) genes (MLH1, MSH2, PMS2, MSH6, and epithelial cellular adhesion molecule), is an autosomal dominant condition accounting for 2–5% of all colorectal carcinomas (CRCs). Reports on MMR loss in many populations are available; however, there are no reports on the frequency of MMR protein expression in Nepalese cohorts. Therefore, this study was aimed to assess the expression profiles of MLH1 and MSH2 protein by immunohistochemistry (IHC) in Nepalese CRC patients.
METHODS This retrospective study used archived formalin-fixed paraffin-embedded tissue blocks from 43 Nepalese CRC patients. IHC staining was performed using MLH1 and MSH2 antibodies. IHC scoring analysis was assessed using semiquantitative scoring.
RESULTS Of the 43 CRC patients, 8 (18.6%) showed loss of staining for MLH1 antibody, 5 (11.6%) showed loss of staining for MSH2 antibody, and 4 (9.3%) showed loss of staining for both MLH1 and MSH2 antibodies.
CONCLUSIONS IHC is a potential screening method of determining the MMR expression profile of Nepalese CRC patients. IHC can be performed in local clinical laboratories to find MMR protein defects in selected cases prior to expensive molecular tests.
User-specific power level allocation optimization for OFDM-NOMA in a multi-user RoF system
Authors: Shi Jin , Chen You-Wei , He Jing , Zhou Zhihua , Yan Xinda , Shiu Run-Kai , Chang Gee-Kung 
Published: July 2020

In this Letter, we propose a digital signal processing (DSP) -aided technique to optimize the power ratio among users for orthogonal frequency division multiplexing (OFDM) -based non-orthogonal multiple access (NOMA) in an integrated optical fiber and millimeter wave (mmWave) wireless communication system. In this way, a central or distributed unit can leverage the proposed techniques to maintain the uniformity of the signal-to-noise ratios (SNRs) among subcarriers without requiring any channel information feedback. The proposed mechanism can facilitate the power allocation management by treating all subcarriers equally as an independent channel. As an illustration, multiple NOMA scenarios, in which a near user with 10 km fiber transmission and far user with either longer fiber distance or additional wireless propagation, are experimentally investigated. Experimental results demonstrate that when the conventional OFDM-NOMA without the proposed DSP-aided technique is used, the optimal power ratios vary rapidly when the subcarrier quality index changes due to high-frequency fading in a mmWave radio over fiber (RoF) system, whereas, by using the proposed techniques, including both orthogonal circulant matrix transform and discrete Fourier transform, the optimal power ratios on all effective subcarriers are optimized at the same level and the users’ performance is significantly improved.
Knowledge of general dentists, endodontists and pediatric dentists about the management on dental traumas: a survey in turkey
Authors: Yusufoğlu Selen İnce , Tulumbacı Fatih 
Published: July 2020

Objective: The purpose of this study was to determine endodontists, pedodontists and general dentists’ knowledge of management of dental trauma. Material and methods: A web-based survey including 13 questions was prepared using Google forms, and a link to the survey was sent to the general dentists, endodontists and paediatric dentists via social media. The questionnaire asked for information regarding the age, gender, state of education, type of institution and knowledge levels about dental traumas. A total of 258 questionnaires were returned, and the One-Way Anova for practitioners' knowledge and the statistical analysis of the relationship between gender, vocational training and training by using Mann-Whitney U tests for participants. Results: As a result of statistical analysis, although there was no statistical difference between pedodontists and endodontists in their knowledge levels, it was found that both occupational groups had higher knowledge level than general dentists (p = 0,0001). While there was a significant difference between practitioners at university and oral and dental health hospital (p = 0.0001), there was no difference between practitioners in university hospital and private office (p = 0.065). Conclusions: In conclusion, general dentists had knowledge of inadequate dental trauma management and the knowledge level of dentists working at oral and dental hospital was lower.KeywordsDental Trauma; Knowledge Level; General Dentist; Endodontists; Pediatric Dentistry.
ASSOCIAÇÃO ENTRE O HÁBITO DE CONSUMO DE CAFÉ DA MANHÃ E ESTADO NUTRICIONAL DE ESTUDANTES UNIVERSITÁRIOS
Authors: Gomes Anna Beatriz Silva , Fernandes Rita de Cassia de Souza , Machado Alisson Diego , Abreu Edeli Simioni de , Spinelli Mônica Glória Neumann 
Published: July 2020

O objetivo do estudo foi avaliar o hábito e a composição do café da manhã de jovens universitários, os fatores que influenciam na realização dessa refeição e sua associação com o estado nutricional. Metodologia: Questionário online disponibilizado em uma plataforma virtual de criação de formulários, contendo dados sociodemográficos (nome, idade, gênero, curso e o exercício de atividade remunerada); dados antropométricos (peso e estatura); questões específicas relacionadas ao consumo de café da manhã, como composição, frequência, horário e local de consumo e companhia; e fatores que influenciam na adoção dessa refeição. Resultados e discussão: Foram analisados 143 universitários. Destes, 67,8% possuem consumo regular de café da manhã, sendo mais consumidos alimentos in natura e minimamente processados. Observou-se que alunos da área biológica realizam o café da manhã com maior frequência do que os universitários das áreas de humanas e exatas. Dos participantes, 23,7% possuíam excesso de peso. Conclusão: O estudo mostrou que apenas o ato de realizar ou não o café da manhã não está associado ao estado nutricional. O estado nutricional referente ao peso adequado se relacionou positivamente com o sexo feminino, não exercer atividade remunerada, satisfação corporal e realizar essa refeição sozinho, assim como a maior preocupação com excesso de peso foi relacionada às mulheres e o maior peso aos universitários que exerciam atividades remuneradas.
EXPERIÊNCIAS DO PIBID QUE AUXILIAM NA MELHORIA DO RENDIMENTO ESCOLAR
Authors: Araujo Irene Coelho de , Duarte Marco Aparecido Queiroz , Lamblém Regina Litz , Neves Eder Pereira 
Published: July 2020

O programa institucional de bolsa de iniciação a docência (PIBID), criado em 2009 pelo Ministério da Educação, busca inserir o estudante de licenciatura em seu futuro ambiente de trabalho durante seu processo de formação, dividido em subprojetos por cursos de graduação. Este trabalho tem como objetivo relatar experiências vivenciadas em atividades desenvolvidas no PIBID em um subprojeto de matemática ao longo de 7 anos. Durante este período de execução foram desenvolvidas atividades envolvendo acadêmicos, professores e alunos de três escolas estaduais do município de Cassilândia-MS. Para avaliar os efeitos das ações nos envolvidos no PIBID foi usada a metodologia da observação participante por meio de informações e experiências anotadas e discutidas nos encontros entre coordenadores, acadêmicos e supervisores do PIBID. Estas atividades colaboraram com a formação docente dos acadêmicos, pois aproximaram a universidade da escola, criando um ambiente favorável ao ensino e melhoria de rendimento escolar dos alunos das escolas participantes.
Republica de Colombia - departamento nacional de planeación plan de desarrollo económico y social 1970-1973
Authors: De Obstetricia y Ginecología Federación Colombiana 
Published: July 2020

La realidad demográfica en Colombia es muy semejante a la que presentan muchos países en desarrollo: rápido crecimiento de la población, altas tasas de fecundidad, descenso rápido de la mortalidad, creciente proporción de personas jóvenes, grandes movimientos de redistribución espacial de la población, rápido crecimiento de los núcleos urbanos y formación incipiente de una clase media.
Traumatismos Ginecológicos en la Infancia
Authors: Pedraza G. Jaime , Michelsen R. Jorge , Arango A. Luzmila , Wargner G. Hebert 
Published: July 2020

Los traumatismos de los órganos genitales en la infancia generalmente son debidos a caídas accidentales sobre objetos romos que producen lesiones contusas, u objetos que penetran en la vagina ocasionando laceraciones más o menos extensas según la causa, la intensidad del traumatismo, así como la intensidad de penetración (3).
Histerectomía Radical para Carcinoma Invasivo de Cuello Uterino - Experiencia de 11 años
Authors: Fonnegra Miramón Alvaro , Guzmán A Rubén Darío , López Luis Vicente 
Published: July 2020

En el año de 1961, los doctores Jorge Villarreal Mejía y Eduardo Cáceres, publicaron un estudio sobre "Carcinoma de cuello uterino, revisión de 58 casos tratados quirúrgicamente" (1), con material del servicio de Ginecología del Hospital San Juan de Dios de Bogotá́, Facultad de Medicina, Universidad Nacional, que abarcaba cinco años consecutivos, de 1955 a 1960.
Variables Epidemiológicas relacionadas con el cáncer de cuello uterino en pacientes con citologías III, IV y V en Popayán - 1971
Authors: Erazo José Vicente , Lara Alvarez Braulio 
Published: July 2020

De 3.519 citologías, tomadas en el área urbana de Popayán, durante 3 años, se encuentran 150 citologías (4,26%) correspondientes a las clases III, IV y V. Los estudios anato- mopatológicos mostraron 115 3,46% para Ca. in situ e invasivo. Las variables epidemiológicas más importantes se pueden resumir así: 1.Edad: La displasiapredominó en los grupos menores de 29 años (42,66%). El Ca. in situ ocupó este mismo grupo y el Ca. invasor por encima de los 45 años. 2. Estado Socio-Económico: 96% con estados socio-económico bajo. 3.Actividad Sexual: Iniciación precoz y prolongada. 4.Paridad: La edad temprana en el primer embarazo y la gran multiparidad de las mujeres del grupo en estudio demarcan una relación constante de aparición temprana a la displasia; factor contributorio hacia el Ca. 5. Aspecto del cérvix: El 30,6% de las citologías positivas presentaron cuello normal; se relieva la importancia de que la lesión neoplásica en epitelio solo es de diagnóstico otológico. 6.Uso de Anticonceptivos: El 60% de pacientes con Ca. cervical no utilizaron anticonceptivos. 7.Destino de la Displasia Cervical. Regresó en el 41 % a estudios normales o subnormales. Progresó a displasia severa en el 9%. No hubo cambios en el 10,60%. Progresaron a Ca. invasor en 1,14%. Progreso a Ca. in situ fué de 2,66% por año, siendo la incidencia de Ca. in situ en mujeres sin displasia de 0.04 por 1.000 mujeres año.
针对性心理护理干预对改善银屑病患者焦虑、抑郁状 态的作用
Authors: 露丹 曹 
Published: July 2020

<div> 探讨针对性心理护理干预对改善银屑病患者焦虑</div><div>、</div><div>抑郁状态产生的作用</div><div>。</div><div>方法 选择</div><div>2017 年</div><div>7</div><div>月至</div><div>2019</div><div>年</div><div>7</div><div>月至我院治疗的</div><div>100</div><div>例银屑病患者当做研究对象</div><div>,</div><div>并以抽签法将入选对象分为对照组</div><div>(50</div><div>例</div><div>)</div><div>及观察组</div><div>(50</div><div>例</div><div>),</div><div>对照组以常规模式施护</div><div>,</div><div>观察组在其基础之上实施针对性心理护理</div><div>,</div><div>对两组</div><div>SAS 评分</div><div>、SDS</div><div>评分以及满意度加以对比</div><div>。</div><div>结果 护理干预前</div><div>,</div><div>两组的</div><div>SAS</div><div>评分及</div><div>SDS</div><div>评分无明显差异</div><div>,</div><div>无统</div><div>计学意义</div><div>,P&gt;0.05;</div><div>护理干预后</div><div>,</div><div>两组的</div><div>SAS</div><div>评分及</div><div>SDS</div><div>评分均低于护理干预前</div><div>,</div><div>差异显著</div><div>,</div><div>有统计学意</div><div>义</div><div>,P&lt;0.05,</div><div>且观察组的</div><div>SAS</div><div>评分及</div><div>SDS</div><div>评分均低于对照组</div><div>,</div><div>差异显著</div><div>,</div><div>有统计学意义</div><div>,P&lt;0.05;</div><div>观察组</div><div>的总体满意率相较于对照组更高</div><div>,</div><div>差异显著</div><div>,</div><div>有统计学意义</div><div>,P&lt;0.05。</div><div>结论 银屑病患者采用针对性心</div><div>理护理干预能够使其负性心理得以改善</div><div>,</div><div>并能够提升患者的满意度</div><div>,</div><div>值得推广</div>
The development of being a professional teacher in the 21st -century model based on the ethics of profession with Buddhism integration
Authors: Areekul Chananporn 
Published: July 2020

The purpose is to develop being a professional teacher in the 21st century model based on the ethics of profession with Buddhism integration. The data were collected from 265 teachers and 20 experts. The instruments were questionnaires and data were analysed by confirmatory factor analysis. The model consisted of (1) the instruction: the 21st century educational philosophy, the curriculum design skill, the educational innovation skill in the classroom, the learning activity management skill, the learning evaluation skill and the classroom action research skill; (2) the ethics of profession for: a person, profession, clients, co-professionals and society; (3) the thinking skills: analytical thinking skill, synthesis thinking skill, critical thinking skill, comparative thinking skill, problem-solving thinking skill and creative thinking skill; and (4) the Buddhist principles: Desana 2, Patisambhida 4, Pamana 4, Desanavidhi 4, Dhammadesaka-dhamma 5, Bahussutanga 5, Anupubbikatha 5 and Kalyanamitta-dhamma 7. The modelâ€™s goodness-of-fit indexes were satisfactory, right and coherent.
Keywords: Buddhism, ethics, profession, teacher, the 21st century.
Innovation of CNC machining education at the Faculty of Technology
Authors: Koleda Peter 
Published: July 2020

The paper describes the ongoing educational project, which is focused on increasing the quality of teaching and making the study more attractive by introducing new selective courses: CNC technology in bachelor study programs and programming of CNC technology in engineering study programs at the Faculty of Technology of the Technical University in Zvolen, Slovakia. The solution of the project is also to create a background for building a CNC machining workplace. Teaching programming takes place in professional CNC emulators that are commonly used in praxis. These emulators allow program debugging, tests, trajectory drawing and optimising and collision checking of tool and workpiece. Altogether 23 students successfully completed the introduced course. Within the project solution, five theses were defended.
Keywords: CNC programming, CNC simulators, teaching, innovation, workplace building.
Motivation for academic work of student – future physical education teachers
Authors: Mitevski Orce , Popeska Biljana Mitevska , Petrusheva Katerina Mitevska 
Published: July 2020

Personal approach toward learning process and interest for learning during university education are underlined as one of the key factors for success during university studies. The aim of this paper is to determine the motivation of students – future physical education teachers for academic work. The study was conducted on a sample of 69 participants, students in the first year at Faculty of physical education, sport and health at University in Skopje, North Macedonia. Questioner comprised from 11 items, designed as 4 – point Likert scale was applied. Three groups of indicators for academic work were determined: active involvement in teaching process; inner self – discipline for learning; strive to supplement and extend personal knowledge. Study results suggest on positive attitude toward academic work and respectively high level of motivation, different approaches in achieving results in academic work. Achieving long – lasting knowledge is underlined as priority in academic work of students included in this study. Obtained results are valuable for university professors indicating the key points that should be consider in order to achieve highly motivated students and maximal learning result.
Keywords: motivation, university students, learning, teaching process;