bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of 2016 WHO classification in the diagnosis of paediatric high-gradeMYC-negative mature B-cell lymphoma with Burkitt-like morphological features
Authors: Zhang Lei , Brown Laura E , Bowen Laurel M , McCarthy Laura C , Cooley Linda D , Repnikova Elena , Gener Melissa A , Garola Robert , August Keith J , Hays J Allyson , Zwick David L , Li Weijie 
Published: January 2020

AimsHistorically, there has been no consensus on the diagnostic classification of high-grade B-cell lymphoma (HGBCL) with morphological features of Burkitt lymphoma (BL) but noMYCgene rearrangement (MYC-negative). The 2016 WHO classification of tumours of haematopoietic and lymphoid tissues has shed some light on this field with the modification of the grey-zone lymphoma with features intermediate between BL and diffuse large B-cell lymphoma, and the creation of several new entities. The aim of this study was to investigate how the revised WHO classification affects our practice in diagnosing these lymphomas in children.MethodsWe retrospectively reviewed cases of mature HGBCL diagnosed at our hospital between 2015 and 2018.ResultsAmong 14 mature HGBCL cases with BL morphological features, 11 showedMYCrearrangement consistent with BL and 3 wereMYC-negative. TwoMYC-negative cases showed regions of 11q gain and loss by microarray consistent with Burkitt-like lymphoma with 11q aberration (BLL-11q). The thirdMYC-negative case showed diffuse and strong MUM1 expression, translocation involving 6p25 by chromosome analysis andIRF4rearrangement by fluorescence in situ hybridisation analysis consistent with large B-cell lymphoma withIRF4rearrangement (LBL-IRF4). All patients were treated according to applicable chemotherapeutic protocols and achieved remission.ConclusionsBLL-11q and LBL-IRF4, two newly defined entities, should be considered in paediatricMYC-negative mature HGBCL cases. Accurate diagnosis needs careful histopathological examination and proper cytogenetic testing. Since they have unique cytogenetic features, specific treatments for them may emerge in the future. Therefore, accurate diagnosis based on the 2016 WHO classification is clinically significant.
Effect of pterygopalatine blockade on perioperative stress and inflammatory outcomes following paediatric cataract surgery
Authors: Oleshchenko Irina , Cok Oya Yalcin , Iureva Tatiana , Zabolotskii Dmitrii , Kripak Anna 
Published: January 2020

BackgroundGeneral anesthesia is required to perform pediatric cataract surgery. To reduce severity of surgical intervention and postoperative complications, regional techniques have been concomitantly used. The traditional regional ophthalmic techniques are retrobulbar, peribulbar and sub-Tenon blocks, which present some technical difficulties and associated complication risks. The pterygopalatine blockade has been exempt of many of these concerns as it is performed out of the orbit. The purpose of this study was to compare the analgesic and anti-inflammatory effects of the pterygopalatine blockade with retrobulbar block in children undergoing elective congenital cataract surgery.MethodsAfter approval of ethics committee and informed consents, patients were enrolled to the study to have either ultrasound-guided pterygopalatine block (group P) or retrobulbar block (group R), with 2 mL lidocaine 2% and 1 mL ropivacaine 0.5%. Hemodynamic monitoring was recorded throughout the perioperative period. Cortisol level and oxidation–reduction status were assessed before and after surgery. Pain and inflammatory response (Tyndall effect, corneal syndrome and edema) were assessed on the first postoperative day.ResultsComparative analysis demonstrated a decrease in cortisol of 123.24% (p˂0.05) and an increase in the redox coefficient of 37.7% (p˂0.05) in group P. Pain intensity was significantly higher in group R until the 16th postoperative hour. The corneal syndrome in patients in group P and group R was noted by 7.6% and in 32.1%, respectively (p˂0.05).ConclusionThe use of the pterygopalatine blockade as a component of anesthesia in pediatric cataract surgery allows reduction of the severity of surgical stress during surgical intervention, providing intraoperative hemodynamic stability and prolonged analgesia.
Applying the 2019 EULAR/ACR lupus criteria to patients from an established cohort: a Latin American perspective
Authors: Pons-Estel Guillermo J , Ugarte-Gil Manuel Francisco , Harvey Guillermina B , Wojdyla Daniel , Quintana Rosana , Saurit Verónica , Soriano Enrique R , Bonfa Eloisa , Massardo Loreto , Cardiel Mario , Vila Luis M , Griffin Russell , Pons-Estel Bernardo A , Alarcón Graciela S 
Published: January 2020

ObjectiveTo evaluate the performance of the 2019 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) systemic lupus erythematosus (SLE) criteria in terms of earlier patients’ classification in comparison to the 1982/1997 ACR or the 2012 Systemic Lupus International Collaborating Clinics (SLICC) criteria.Materials and methodsPatients from a Latin America, multiethnic, multicentre cohort, where SLE was defined using the physicians’ diagnosis, were included. To calculate the sensitivity of the 2019 EULAR/ACR criteria, the 1982/1997 ACR criteria were considered the gold standard. Additionally, comparison of the 1982/1997 ACR criteria and the 2012 SLICC criteria with the 2019 EULAR/ACR criteria was performed.ResultsThe sensitivity of the 2019 EULAR/ACR criteria when compared with the 1982/1997 ACR criteria as the gold standard was 91.3%. This new set of criteria allowed an earlier SLE patient classification in 7.4% (mean 0.67 years) and 0.6% (mean 1.47 years) than the 1982/1997 ACR and the 2012 SLICC criteria, respectively. Patients accruing the 2019 EULAR/ACR earlier than the 1982/1997 ACR criteria were more likely to have high anti-dsDNA titres; those accruing them later were less likely to have mucocutaneous and joint manifestations; this was not observed when comparing them with the 2012 SLICC criteria.ConclusionsThe 2019 EULAR/ACR criteria classified earlier only a small proportion of Latin America patients than with the two other criteria sets in real-life clinical practice scenarios. Further studies in different patient populations are needed before these new criteria are adopted worldwide.
Primary bone hemangiosarcoma involving the 4th digit in a Siberian Husky dog
Authors: Moon Jeonghyeon , Hillers Kim , Kim Min Su 
Published: January 2020

An 11‐year‐old female spayed Siberian Husky was presented with a left hind, swollen, bleeding mass involving digit 4. Radiographs revealed osteolytic lesions involving the distal phalanx (P3) and part of the middle phalanx (P2). Digit amputation was performed; histopathology was consistent with hemangiosarcoma. Although no signs of systemic involvement were detected around the time of amputation, the patient was euthanised 47 days later due to regional and distant metastasis.
Tectonic interpretation of active fault extending in Myanmar, Laos and China by relief map of ASTER GDEM and harmonized geological map
Authors: Okubo Yasukuni , Soe Myint , Takahashi Yutaka , Wongsomsak Sompob , Fujita Masaru 
Published: January 2020

Abstract

In 24 March 2011, an earthquake on the scale of
M
w
6.8 occurred at the west end of the Nam Ma Fault, which is 215 km long, crossing Myanmar, Laos and China. The rupture occurred on a 30 km-long segment in Myanmar. The earthquake was limited to individual segments, reducing its magnitude. The ASTER GDEM is accessible from a download site. Its relief map illustrates linear features reflecting fault scarps, step-overs, pull-apart areas and bends associated with tectonic deformation. A harmonized geological map of the study area that was continuous over the cross-border areas was compiled. The map reveals lithologies, ages of formations, continuous displacement lines and exotic terranes. Intensive field surveys provided information on tectonics in Myanmar while on the Laos side intensive surveys were not conducted. The ASTER GDEM data and the harmonized geological maps were used to support mapping of the entire segmentation of the Nam Ma Fault. The mapped Nam Ma Fault consists of five segments. Estimated slip-plane areas and magnitudes of possible earthquakes of the respective segments indicate that the greatest magnitude is 7.3 in the case of rupture of a 100 km long segment.
Protective role of cardiac-specific overexpression of caveolin-3 in cirrhotic cardiomyopathy
Authors: Kim So Yeon , Kim Kang Ho , Schilling Jan M. , Leem Joseph , Dhanani Mehul , Head Brian P. , Roth David M. , Zemljic-Harpf Alice E. , Patel Hemal H. 
Published: January 2020

Cirrhotic cardiomyopathy is a clinical syndrome in patients with liver cirrhosis characterized by blunted cardiac contractile responses to stress and/or heart rate-corrected QT (QTc) interval prolongation. Caveolin-3 (Cav-3) plays a critical role in cardiac protection and is an emerging therapeutic target for heart disease. We investigated the protective role of cardiac-specific overexpression (OE) of Cav-3 in cirrhotic cardiomyopathy. Biliary fibrosis was induced in male Cav-3 OE mice and transgene negative (TGneg) littermates by feeding a diet containing 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC; 0.1%) for 3 wk. Liver pathology and blood chemistries were assessed, and stress echocardiography, telemetry, and isolated heart perfusion studies to assess adrenergic responsiveness were performed. Cav-3 OE mice showed a similar degree of hyperdynamic contractility, pulmonary hypertension, and QTc interval prolongation as TGneg mice after 3 wk of DDC diet. Blunted systolic responses were shown in both DDC-fed Cav-3 OE and TGneg hearts after in vivo isoproterenol challenge. However, QTc interval prolongation after in vivo isoproterenol challenge was significantly less in DDC-fed Cav-3 OE hearts compared with DDC-fed TGneg hearts. In ex vivo perfused hearts, where circulatory factors are absent, isoproterenol challenge showed hearts from DDC-fed Cav-3 OE mice had better cardiac contractility and relaxation compared with DDC-fed TGneg hearts. Although Cav-3 OE in the heart did not prevent cardiac alterations in DDC-induced biliary fibrosis, cardiac expression of Cav-3 reduced QTc interval prolongation after adrenergic stimulation in cirrhosis. NEW & NOTEWORTHY Prevalence of cirrhotic cardiomyopathy is up to 50% in cirrhotic patients, and liver transplantation is the only treatment. However, cirrhotic cardiomyopathy is associated with perioperative morbidity and mortality after liver transplantation; therefore, management of cirrhotic cardiomyopathy is crucial for successful liver transplantation. This study shows cardiac myocyte specific overexpression of caveolin-3 (Cav-3) provides better cardiac contractile responses and less corrected QT prolongation during adrenergic stress in a cirrhotic cardiomyopathy model, suggesting beneficial effects of Cav-3 expression in cirrhotic cardiomyopathy.
A Moan of Pleasure Should Be Breathy: The Effect of Voice Quality on the Meaning of Human Nonverbal Vocalizations
Authors: Anikin Andrey 
Published: January 2020

AbstractProsodic features, such as intonation and voice intensity, have a well-documented role in communicating emotion, but less is known about the role of laryngeal voice quality in speech and particularly in nonverbal vocalizations such as laughs and moans. Potentially, however, variations in voice quality between tense and breathy may convey rich information about the speaker’s physiological and affective state. In this study breathiness was manipulated in synthetic human nonverbal vocalizations by adjusting the relative strength of upper harmonics and aspiration noise. In experiment 1 (28 prototypes × 3 manipulations = 84 sounds), otherwise identical vocalizations with tense versus breathy voice quality were associated with higher arousal (general alertness), higher dominance, and lower valence (unpleasant states). Ratings on discrete emotions in experiment 2 (56 × 3 = 168 sounds) confirmed that breathiness was reliably associated with positive emotions, particularly in ambiguous vocalizations (gasps and moans). The spectral centroid did not fully account for the effect of manipulation, confirming that the perceived change in voice quality was more specific than a general shift in timbral brightness. Breathiness is thus involved in communicating emotion with nonverbal vocalizations, possibly due to changes in low-level auditory salience and perceived vocal effort.
Percutaneous Mechanical Unloading Simultaneously With Reperfusion Induces Increased Myocardial Salvage in Experimental Acute Myocardial Infarction
Authors: Ko Byungsoo , Drakos Stavros G. , Ibrahim Homam , Kang Tae Soo , Thodou Aspasia , Bonios Michael , Taleb Iosif , Welt Frederick GP. 
Published: January 2020

Background:
Despite advances in reperfusion times, patients presenting with acute myocardial infarction carry an unacceptably high rate of mortality and morbidity. Mechanical unloading of the left ventricle (LV) has been suggested to reduce infarct size after acute myocardial infarction. Although prior studies have investigated LV unloading during ischemia with a delay in reperfusion, little is known about the optimal timing for LV unloading in the setting of acute myocardial infarction.

Methods:
Studies were conducted in 17 adult Yorkshire swine weighing 67±5 kg. A coronary balloon was inflated in the mid left anterior descending for 60 minutes to induce a myocardial infarction. The coronary balloon was then deflated for 120 minutes (reperfusion). The animals were stratified into 3 groups: group 1 (control, reperfusion with no LV unloading, n=5), group 2 (LV unloading during ischemia with delayed reperfusion, n=6), and group 3 (simultaneous LV unloading and reperfusion, n=6). Staining the hearts with Evans blue and 2,3,5-triphenyltetrazolium chloride was used to identify the area at risk and the infarct area respectively. Infarct percent size was defined as the area of infarcted myocardium divided by the area at risk.

Results:

Of the 3 groups, group 3 demonstrated significantly smaller infarct percent size compared with controls (54.7±20.3% versus 22.2±13.4%;
P
=0.03). Comparison between group 1 and group 2 did not reveal significant difference (54.7±20.3% versus 43.3±24.6%;
P
=0.19).

Conclusions:
In our large animal experimental model, simultaneous reperfusion and mechanical LV unloading yielded the smallest infarct size compared with no LV unloading or LV unloading with delayed reperfusion. In the context of prior studies showing benefit to unloading before reperfusion, these findings raise questions about how this strategy may be translated to humans.
Slug, a Cancer‐Related Transcription Factor, is Involved in Vascular Smooth Muscle Cell Transdifferentiation Induced by Platelet‐Derived Growth Factor‐BB During Atherosclerosis
Authors: Ledard Nahéma , Liboz Alexandrine , Blondeau Bertrand , Babiak Mégane , Moulin Célia , Vallin Benjamin , Guillas Isabelle , Mateo Véronique , Jumeau Claire , Blirando Karl , Meilhac Olivier , Limon Isabelle , Glorian Martine 
Published: January 2020

Background

Heart attacks and stroke often result from occlusive thrombi following the rupture of vulnerable atherosclerotic plaques. Vascular smooth muscle cells (
VSMC
s) play a pivotal role in plaque vulnerability because of their switch towards a proinflammatory/macrophage‐like phenotype when in the context of atherosclerosis. The prometastatic transcription factor Slug/Snail2 is a critical regulator of cell phenotypic transition. Here, we aimed to investigate the role of Slug in the transdifferentiation process of
VSMC
s occurring during atherogenesis.

Methods and Results

In rat and human primary aortic smooth muscle cells, Slug protein expression is strongly and rapidly increased by platelet‐derived growth factor‐BB (PDGF‐
BB
).
PDGF
‐
BB
increases Slug protein without affecting
mRNA
levels indicating that this growth factor stabilizes Slug protein. Immunocytochemistry and subcellular fractionation experiments reveal that
PDGF
‐
BB
triggers a rapid accumulation of Slug in
VSMC
nuclei. Using pharmacological tools, we show that the
PDGF
‐
BB
–dependent mechanism of Slug stabilization in
VSMC
s involves the extracellular signal‐regulated kinase 1/2 pathway. Immunohistochemistry experiments on type V and type
VI
atherosclerotic lesions of human carotids show smooth muscle–specific myosin heavy chain–/Slug‐positive cells surrounding the prothrombotic lipid core. In
VSMC
s, Slug si
RNA
s inhibit prostaglandin E2 secretion and prevent the inhibition of cholesterol efflux gene expression mediated by
PDGF
‐
BB
, known to be involved in plaque vulnerability and/or thrombogenicity.

Conclusions
Our results highlight, for the first time, a role of Slug in aortic smooth muscle cell transdifferentiation and enable us to consider Slug as an actor playing a role in the atherosclerotic plaque progression towards a life‐threatening phenotype. This also argues for common features between acute cardiovascular events and cancer.
<p><strong>Morphological and molecular evidence for a new species from China: <em>Piper semi-transparens</em> (Piperaceae)</strong></p>
Authors: HAO CHAO-YUN , WU BAO-DUO , QIN XIAO-WEI , WU GANG , DENG HAI-YAN , TAN YUN-HONG 
Published: January 2020

We conducted morphological and molecular analyses to describe a new species of Piperaceae, Piper semi-transparens, which was observed in Hainan, Guangdong and Guangxi Provinces, China. Detailed morphological comparisons between the newly discovered species and other members of Piper indicate that Piper semi-transparens is similar to P. bonii and P. bonii var. macrophyllum, from which it differs in having glabrous leaf blades; stem densely short and unbranched pubescent when young, glabrous when mature; veins 5(–7); stamens 2; stigmas 3, rarely 4; spikes color white when mature; floral bracts glabrous; pericarp white and semi-transparent. Molecular analyses based on the ITS marker of nuclear ribosomal DNA strongly support that P. semi-transparens is a new species in the genus Piper, most closely related to P. bonii and P. bonii var. macrophyllum.
Suggestion of Spongia (Heterofibria) peddemorsi as replacement name for <br />Spongia (Heterofibria) cooki Samaai, Pillay &amp; Janson, 2019
Authors: SAMAAI TOUFIEK , PILLAY RUWEN , JANSON LIESL 
Published: January 2020

Rob Van Soest (pers. communication) remarked that Spongia (Heterofibria) cooki Samaai, Pillay & Janson, 2019 is a junior primary homonym of Spongia vermiculata cookii Hyatt, 1877, now accepted as Spongia (Spongia) cookii Hyatt, 1877. Following the ICZN (art. 57.2, art. 58.14 [regarding -ii and -i], ICZN 1999) the published species name (Samaai et al. 2019) is unavailable and we now suggest replacing the name with Spongia (Heterofibria) peddemorsi following art. 60, ICZN (1999). The holotype is deposited into the collection at the Iziko South African Museum, Cape Town, SAM-A24791, for further collection data see Samaai et al. 2019.
4. Naves Pingere
Authors: Galinier Martin , Nantet Emmanuel 
Published: January 2020

During the Hellenistic period, various kinds of evidence demonstrate the existence of many large ships whose tonnage was greater than one hundred tonnes and could even reach several hundred tonnes. However, the accurate evolution of their tonnage is more complicated to determine for ships that sailed in the Eastern Mediterranean. It seems that an initial increase occurred in the first part of the second century BCE all over the Mediterranean. This particularly affected wheat and stone, since these goods required large ships. The increase in tonnage during this period was due to a desire for more prestige, influenced by political and military factors, and less to do with a desire for increased profits.
A second rise seems to have occurred from the end of the second century to the beginning of the first century BCE. However, this growth was restricted to particular routes in the Mediterranean, and only to ships carrying very valuable merchandise, such as wine or works of art. In fact, the development in tonnage was obviously the result of the significant changes in maritime trade caused by Roman rule.
Beyond these factors, the growth in tonnage during the Hellenistic period is due to developments in both ship and harbour technologies. Of course, the economic background — the growth of cities in the Hellenistic world — helped stimulate the demand for big ships.
Is the Height of the Arcuate Eminence Related to Body Mass Index?
Authors: Coelho Daniel H. , Fasulo Bradley , Quinn Kevin , Tang Yang , Sima Adam , Forsthoffer Brielle 
Published: January 2020

ObjectivesTo determine the relationship, if any, between body mass index (BMI) and attenuation of the arcuate eminence (AE).Study DesignCase series with chart review.SettingTertiary neurotologic referral center.Subjects and MethodsSubmillimeter distances were recorded from high‐resolution temporal bone computed tomography (CT) scans of 50 patients (100 sides). The AE (defined as the superiormost location of the petrous bone over the otic capsule), the bony apex of the superior semicircular canal (SSC), and the geniculate ganglion (GG) were identified and 3‐dimensional distances measured. The height of the AE relative to the bony apex of the superior semicircular canal was determined using Euclidean geometry using the fixed anatomical landmark of the GG as the origin. Correlations between AE and BMI were calculated using Pearson’s, linear mixed effects, and sensitivity analysis models.ResultsThe mean (SD) BMI was 30 (8.1) kg/m2, with 16 (30%) patients falling in the underweight/normal category (BMI <25 kg/m2), 10 (20%) overweight patients (25 kg/m2≤ BMI ≤ 30 kg/m2), and 24 (48%) patients considered obese (BMI >30 kg/m2). The mean (SD) AE heights for the left and right ears were 2.5 (1.11) and 2.6 (1.09), respectively. The results of the linear mixed‐effects models indicated little evidence that BMI is associated with AE height when including all patients (partial R2 = 0.040) and when using BMI categories (partial R2 = 0.025).ConclusionContrary to other structures within the lateral skull base, the relative prominence of the arcuate eminence does not correlate with BMI or any other demographic variables.
Utilization of Diagnostic Testing for Renal Anomalies and Congenital Heart Disease in Patients with Microtia
Authors: Ramprasad Vaibhav H. , Shaffer Amber D. , Jabbour Noel 
Published: January 2020

ObjectiveCongenital ear anomalies are associated with congenital cardiac and renal defects. Renal ultrasounds, electrocardiogram, and echocardiogram can be utilized for diagnosis of these concurrent defects. No standard of care exists for the workup of patients with microtia. The goals of this study were to describe the utilization of diagnostic testing for cardiac and renal anomalies and to identify their prevalence in patients with microtia.Study DesignCase series with chart review.SettingChildren’s Hospital of Pittsburgh of the University of Pittsburgh Medical Center.Subjects and MethodsThis study is an Institutional Review Board–approved retrospective review of consecutive patients born between 2002 and 2016 who were diagnosed with microtia and seen in the otolaryngology clinic at a tertiary care children’s hospital. Demographics, sidedness and grade of microtia, comorbid diagnoses, and details of renal and cardiovascular evaluations were recorded. Factors associated with retroperitoneal ultrasound and cardiac testing were assessed with logistic regression.ResultsMicrotia was present in 102 patients, and 98 patients were included as they received follow‐up. Microtia was associated with craniofacial syndrome in 34.7% of patients. Renal ultrasound was performed in 64.3% of patients, and 12.9% of patients with ultrasounds had renal aplasia. Cardiac workup (electrocardiogram or echocardiogram) was completed in 60.2% of patients, and of this subset, 54.2% had a congenital heart defect.ConclusionDiagnostic testing revealed renal anomalies and cardiac defects in patients with isolated microtia at a higher rate than in the general population. This suggests the need for further evaluation of the role of routine screening in patients with microtia.