bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isolation, spectral characterization and biological activity of fractions of the flavonoid-containingGratiola officinalisL. extract
Authors: Shirokov Alexander , Grinev Vyacheslav , Polukonova Natalya , Verkhovsky Roman , Doroshenko Alena , Mudrak Dmitry , Navolokin Nikita , Polukonova Anna , Bucharskaya Alla , Maslyakova Galina 
Published: December 2020

AbstractThe extract ofG. officinaliswas separated by five major fractions and the antitumor activity of hydrophobic fractions has been established. For the most active fractions spectral investigations of the main component were performed using UV-Vis electronic spectra, circular dichroism (CD), Fourier-transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR) spectroscopy. On the basis of spectral characteristics, it was demonstrated that the main components of the fractions4and5ofG. officinalisproviding its biological activity, highly likely, are of flavonoid nature. Based on the NMR data we propose the structure of the aglycon moiety of the main component from fraction4as 4,2’,5’-trihydroxychalcone. The fraction5is the most active, the antitumor effect of which is implemented through cytotoxic, cytostatic, apoptotic and autophagosomal activity in respect to human kidney cancer tumor cells.
The Erythropoietin Receptor Stimulates Rapid Cycling and Formation of Larger Red Cells During Mouse and Human Erythropoiesis
Authors: Hidalgo Daniel , Bejder Jacob , Pop Ramona , Gellatly Kyle , Scalf S. Maxwell , Eastman Anna E. , Chen Jane-Jane , Zhu Lihua Julie , Heuberger Jules A.A.C. , Guo Shangqin , Koury Mark J. , Nordsborg Nikolai Baastrup , Socolovsky Merav 
Published: December 2020

AbstractErythroid terminal differentiation entails cell divisions that are coupled to progressive decreases in cell size. EpoR signaling is essential for the survival of erythroid precursors, but it is unclear whether it has other functions in these cells. Here we endowed mouse precursors that lack the EpoR with survival signaling, finding that this was sufficient to support their differentiation into enucleated red cells, but that the process was abnormal. Precursors underwent fewer and slower cell cycles and yet differentiated into smaller red cells. Surprisingly, EpoR further accelerated cycling of early erythroblasts, the fastest cycling cells in the bone marrow, while simultaneously increasing their cell size. EpoR-mediated formation of larger red cells was independent of the established pathway regulating red cell size by iron through Heme-regulated eIF2α kinase (HRI). We confirmed the effect of Epo on red cell size in human volunteers, whose mean corpuscular volume (MCV) increased following Epo administration. This increase persisted after Epo declined and was not the result of increased reticulocytes. Our work reveals a unique effect of EpoR signaling on the interaction between the cell cycle and cell growth. Further, it suggests new diagnostic interpretations for increased red cell volume, as reflecting high Epo and erythropoietic stress.
Institutional logics and practice variations in sustainability reporting: evidence from an emerging field
Authors: Mahmood Zeeshan , Uddin Shahzad 
Published: December 2020

PurposeThis paper aims to deepen the understanding of logics and practice variation in sustainability reporting in an emerging field.Design/methodology/approachThis paper adopts the institutional logics perspective and its conceptualization of society as an inter-institutional system as a theoretical lens to understand reasons for the presence of and variation in sustainability reporting. The empirical findings are based on analysis of 28 semi-structured interviews with significant social actors, and extensive documentary evidence focusing on eight companies pioneering sustainability reporting in Pakistan.FindingsThis paper confirms the presence of multiple co-existing logics in sustainability practices and lack of a dominant logic. Sustainability reporting practices are underpinned by a combination of market and corporate (business logics), state (regulatory logics), professional (transparency logics) and community (responsibility logics) institutional orders. It is argued that institutional heterogeneity (variations in logics) drives the diversity of motivations for and variations in sustainability reporting practices.Research limitations/implicationsThe paper offers a deeper theoretical explanation of how various logics dominate sustainability reporting in a field where the institutionalization of practice is in its infancy.Practical implicationsUnderstanding the conditions that influence the logics of corporate decision-makers will provide new insights into what motivates firms to engage in sustainability reporting. A broader understanding of sustainability reporting in emerging fields will foster its intended use to increase transparency, accountability and sustainability performance.Originality/valueThis paper contributes to relatively scarce but growing empirical research on emerging fields. Its major contribution lies in its focus on how multiple and conflicting institutional logics are instantiated at the organizational level, leading to wide practice variations, especially in an emerging field. In doing so, it advances the institutional logics debate on practice variations within the accounting literature.
Chohan Decoration Services Pakistan – survival amid COVID-19
Authors: Shaikh Abdul Rehman , Qazi Asad Ali 
Published: December 2020

Learning outcomes
The learning outcomes of this paper is as follows: understand the impact of macroeconomic challenges on startups; gain insights into the effects of self-management attribute over entrepreneurial effectiveness and performance; create a conceptual framework for customer satisfaction; analyze the internal and external factors affecting the entrepreneurial journey of new startups.

Case overview/synopsis
This case revolves around the entrepreneurial journey of Mr Khursheed Chohan who belonged to Sukkur (Pakistan). He started his journey as a daily wage worker in the year 2002 at the age of 17 years. After one year he acquired a rickshaw on rent and would drive the same as a taxi. In the year 2006, he started the job as a private driver. For achieving his dreams, he moved to Karachi (the land of opportunities) at the age of 27 years. During his stay in Karachi, he learned about insights into the wedding decoration industry. Keeping in view the market requirements, he also took some training courses on learning computers. By the age of 34, he returned to his hometown with the will to start his business venture of wedding decoration services. It had been around one year, he was successfully running his business. However, the emergence of Coronavirus (COVID-19) and the imposition of lockdown over businesses were his most recent challenges. While Chohan had pre-booked several orders and secured advance money, shall he be able to survive the COVID-19 effects? Shall he be able to continue his entrepreneurial journey?

Complexity academic level
Undergraduate.

Supplementary materials
Teaching Notes are available for educators only.

Subject code
CSS 3: Entrepreneurship.
Failure mode and effect analysis (FMEA) of radiotherapy
Authors: Govindarajan Rajaram , Laeequddin Mohammed 
Published: December 2020

Learning outcomes
Learning outcomes are as follows: students will discover the importance of process orientation in management; students will determine the root cause of the problem by applying root cause analysis technique; students will identify the failure modes, analyze their effect, score them on a scale and prioritize the corrective action to prevent the failures; students will analyze the processes and propose error-proof system/s; and students will analyze organizational culture and ethical issues.

Case overview/synopsis
Purpose: This case study is intended as a class-exercise, for students to discover the importance of process-orientation in management, analyze the ethical dilemma in health care and to apply quality management techniques, such as five-why, root cause analysis, failure mode and effect analysis (FMEA) and error-proofing, in the management of the health-care and service industry. Design/methodology/approach: A voluntary reporting of a case of “radiation overdose” in a hospital’s radio therapy treatment unit, which led to an ethical dilemma. Consequently, a study was conducted to establish the causes of the incident and to develop a fail-proof system, to avoid recurrence. Findings: After careful analysis of the process-flow and the root causes, 25 potential failure modes were detected and the team had assigned a risk priority number (RPN) for each potential incident, selected the top ten RPNs and developed an error-proofing system to prevent recurrence. Subsequently, the improvement process was carried out for all the 25 potential incidents and a new control mechanism was implemented. The question of ethical dilemma remained unresolved. Research limitations/implications: Ishikawa diagram, FMEA and Poka-Yoke techniques require a multi-disciplinary team with process knowledge in identifying the possible root causes for errors, potential risks and also the possible error-proofing method/s. Besides, these techniques need frank discussions and agreement among team members on the efforts for the development of action plan, implementation and control of the new processes. Practical implications: Students can take the case data to identify root cause analysis and the RPN (RPN = possibility of detection × probability of occurrence × severity), to redesign the protocols, through systematic identification of the deficiencies of the existing protocols. Further, they can recommend quality improvement projects. Faculty can navigate the case session orientation, emphasizing quality management or ethical practices, depending on the course for which the case is selected.

Complexity academic level
MBA or PG Diploma in Management – health-care management, hospital administration, operations management, services operations, total quality management (TQM) and ethics.

Supplementary materials
Teaching Notes are available for educators only.

Subject code
CSS 9: Operations and Logistics.
The role of the Big 4 and second-tier international networks in redeveloping China’s audit market
Authors: Lento Camillo , Yeung Wing Him 
Published: December 2020

Purpose
This study aims to explore the audit quality supplied by the Big 4, large indigenous Chinese (LIC) and five largest second-tier international network (Tier 2) audit firms in China during the second phase of their audit market development.

Design/methodology/approach
Ordinary least squares regression is used on an archival sample of firm-year observations. Endogeneity and self-selection bias are addressed by creating a propensity score matched sample and using two-stage regression with the inverse Mills’ ratio.

Findings
Strong evidence is found for higher levels of actual audit quality for the Big 4 relative to both LIC and Tier 2 audit firms. Weak evidence is found regarding the audit quality superiority of Tier 2 relative to LIC audit firms. Furthermore, the actual audit quality differential between the Big 4 relative to the LIC and Tier 2 firms widens after adopting International Financial Reporting Standards, which is contrary to the intention of Chinese regulators.

Originality/value
To the best of the authors’ knowledge, this is the first known empirical study to trisect Big N and non-Big N audit firm proxies into the Big 4, LIC and Tier 2. Currently, only qualitative studies have fully appreciated the unique regulatory roles of these three firm structures in developing China’s audit market, which reflect tensions between reliance on foreign expertise and self-determination. In addition, this study adds to the ongoing global dialogue on Tier 2 as an alternative to the Big 4 and the benefits of international accounting network membership.
From CEO passion to exploratory and exploitative innovation: the moderating roles of market and technological turbulence
Authors: Cai Wenjun , Wu Jianlin , Gu Jibao 
Published: December 2020

PurposeInnovation has been identified as a critical element to achieve firms' growth. The purpose of this study is to investigate the impact of chief executive officer (CEO) passion on firm innovation, including exploratory and exploitative innovation and examine the moderating roles of market and technological turbulence.Design/methodology/approachThis study adopts the methodology of survey and uses multisource and time-lagged data of 146 firms in China. Seemingly unrelated regression (SUR) is used to test the hypotheses of this study.FindingsThis study finds that CEO passion promotes exploratory and exploitative innovation. Results also indicate that market turbulence strengthens the effect of CEO passion on exploratory and exploitative innovation, whereas technological turbulence weakens such an effect.Originality/valueCEO passion is an important, positive affect which inspires CEOs to work for firms, but it has not yet received enough attention in the innovation literature. This study contributes to examining the impact of CEO passion on firm innovation and contributes to the contingency under which CEO passion influences firm innovation. Furthermore, this research finds that the moderating effects of market and technological turbulence are different in the relationship between CEO passion and firm innovation.
The presumed influence of digital misinformation: examining US public’s support for governmental restrictions versus corrective action in the COVID-19 pandemic
Authors: Cheng Yang , Luo Yunjuan 
Published: December 2020

PurposeInformed by the third-person effects (TPE) theory, this study aims to analyze restrictive versus corrective actions in response to the perceived TPE of misinformation on social media in the USA.Design/methodology/approachThe authors conducted an online survey among 1,793 adults in the USA in early April. All participants were randomly enrolled in this research through a professional survey company. The structural equation modeling via Amos 20 was adopted for hypothesis testing.FindingsResults indicated that individuals also perceived that others were more influenced by misinformation about COVID-19 than they were. Further, such a perceptual gap was associated with public support for governmental restrictions and corrective action. Negative affections toward health misinformation directly affected public support for governmental restrictions rather than corrective action. Support for governmental restrictions could further facilitate corrective action.Originality/valueThis study examined the applicability of TPE theory in the context of digital health misinformation during a unique global crisis. It explored the significant role of negative affections in influencing restrictive and corrective actions. Practically, this study offered implications for information and communication educators and practitioners.Peer reviewThe peer review history for this article is available at:https://publons.com/publon/10.1108/OIR-08-2020-0386
Whole community co-production: a full picture behind the successful COVID-19 response in S. Korea
Authors: Yeo Jungwon , Lee Eun Sun 
Published: December 2020

PurposeThis study aims to examine and understand South Korea’s (S. Korea) COVID-19 response operations, a notable case for other countries to emulate, and suggest some practical implications for other countries struggling with coping with the current pandemic.Design/methodology/approachTo examine the case, the authors propose a new theoretical framework based on concepts of the whole community approach in the emergency management field and on co-production in public administration studies, and use the theoretical framework to analyze the details of S. Korea’s whole community co-production for COVID-19 response.FindingsThe findings demonstrate that the successful pandemic response in S. Korea is attributable to a nationwide whole community co-production among multiple actors, including government, various industries, sectors, jurisdictions and even individual citizens, within and across relevant public service and public policy domains.Originality/valueThis study suggests a new theoretical framework, whole community co-production, which contributes to the conceptual advancement of co-production in the field of public administration and a whole community approach in the field of emergency and crisis management. The framework also suggests practical implications for other countries to integrate whole community coproduction that may transform current response operations to cope with COVID-19.
Leader dark personality and team agreeableness: a recipe for volatile team performance
Authors: Uppal Nishant 
Published: December 2020

Purpose
This paper aims to examine the effects of the leaders’ dark triad (DT) personality traits, namely, Machiavellianism, Narcissism and Psychopathy, on the team performance variability. Furthermore, this work explores the role of team agreeableness in the above relationship.

Design/methodology/approach
The study is based on the longitudinal and archival data obtained from the sales team (team leaders: n = 190; team members: n = 832) of 19 firms dealing with fast-moving consumer goods in India.

Findings
From the finding of the study, it can be inferred that the presence of DT traits in the leaders causes high fluctuations in team performance. Besides, team agreeableness was found to moderate the relationship between the DT traits of the leaders and the team performance variability.

Originality/value
The theoretical and practical implications of the study are also discussed.
Pemphigus vulgaris in two pairs of siblings from two unrelated Italian families: Human leukocyte antigen genotypes, ST18 mutation and immunological profile
Authors: Fania Luca , Moro Francesco , De Paolis Elisa , Provini Alessia , Salemme Adele , Mariotti Feliciana , Sinagra Jo Linda Maria , Mazzanti Cinzia , Ruzzi Laura , Capoluongo Ettore , Di Zenzo Giovanni 
Published: December 2020

AbstractPemphigus vulgaris (PV) is an autoimmune intraepithelial bullous disease. Associations with the class II human leukocyte antigen (HLA) alleles and pemphigus vulgaris have been described. Furthermore, an association between the single nucleotide polymorphism of the ST18 gene and pemphigus vulgaris has been reported. We report two pairs of siblings from two unrelated Italian families affected by pemphigus vulgaris, characterizing their genetic and immunological profile. In order to assess the genetic background, HLA‐DQA1, HLA‐DQB1, HLA‐DRB1 and a relevant ST18 polymorphism were investigated. As for the immunological profiles, anti‐desmoglein antibodies were analyzed. In family A, the two pemphigus vulgaris patients had the same HLA genetic profile: HLA‐DQA1 *01:04/*03:01, HLA‐DQB1 *03:02/*05:03 and HLA‐DRB1 *04:02/*14:01. The male patient was heterozygous for the ST18 mutation while the female patient had a wild genotype. In family B, the two pemphigus vulgaris patients were both wild type for the ST18 mutation and showed the same HLA genotype: HLA‐DQA1 *03:01/*05:08, HLA‐DQB1 *03:01/*03:03 and HLA‐DRB1 *04:02/*11:01. Our data show a relevant relationship between the HLA profile and pemphigus vulgaris in our Italian families. In family A, all six alleles are frequently associated with pemphigus vulgaris and were expressed only in the two pemphigus patients; and in family B, two of the six alleles are frequently associated with pemphigus vulgaris. No relevant relationship was found between ST18 polymorphism and pemphigus disease.
In‐service mathematics teachers’ video‐based noticing of 3D printing pens “in action”
Authors: Ng Oi‐Lam , Chan To 
Published: December 2020

AbstractWe adopt five observation categories, namely classroom management, classroom environment, communication, mathematical content and tasks, to analyse four in‐service secondary mathematics teachers’ noticing upon watching video episodes showing an actual mathematics lesson that implemented 3D Printing Pens for teaching and learning shape and space. We use coding to analyse what the participants generally identified as important or noteworthy in the video. Moreover, we employ thematic analysis to delve deeper into the participants’ interpretations and decisions in relation to using 3D Pens for teaching and learning mathematics. Our findings have implications for teachers’ professional development in the area of technology integration especially in terms of their realisation of the affordances of novel‐to‐them technologies. We also report methodological and conceptual contributions towards teacher noticing.
Practitioner notesWhat is already known about this topic

Various frameworks have been proposed for conceptualising teachers’ expertise in technology‐rich pedagogies; however, few have addressed teachers’ initial experience of adopting a novel‐to‐them technology in subject teaching.
In teacher education, the method of video‐based noticing has been widely undertaken in the last two decades to help preservice and in‐service teachers visualise complex classroom situations and interpret classroom events.
What this paper adds

This study investigates what in‐service mathematics teachers find significant, the pedagogical considerations they make and their professional development in integrating technologies for teaching and learning mathematics.
Particularly, video‐based noticing is used as a means for facilitating teachers’ professional growth through realising the affordances of 3D Printing Pens in mathematics education.
Implications for practice and/or policy

This study provides qualitative evidence that video‐based noticing was productive in facilitating teachers’ technological, pedagogical and content knowledge (TPACK), in particular, in realising the educational affordances of a novel‐to‐them technology.
The videos captured the dynamic process of students’ drawing with 3D Pens “in action” rather than merely capturing their final products in a static manner, which facilitated the teachers’ reflections about the evolution of students’ mathematical thinking.
Effects of a whey protein pre‐meal on bone turnover in participants with and without type 2 diabetes—A post hoc analysis of a randomised, controlled, crossover trial
Authors: Bjørnshave Ann , Lykkeboe Simon , Hartmann Bolette , Holst Jens J. , Hermansen Kjeld , Starup‐Linde Jakob 
Published: December 2020

AbstractAimsWhey protein may improve bone turnover and have anti‐osteoporotic effects. The aim of the present randomised, controlled, crossover trial was to evaluate the effects of a whey protein pre‐meal on bone turnover in people with type 2 diabetes and controls.MethodsTwo groups, matched on sex, age and body mass index, comprising 12 participants with and 12 participants without type 2 diabetes were randomly given a pre‐meal of whey protein (20 g) or water, which was consumed 15 min before a fat‐rich meal or a fat‐rich meal supplemented with 20 g whey protein. During a 360‐min period, postprandial responses in bone turnover were examined.ResultsOsteocalcin, P‐procollagen type 1 amino terminal propeptide (P1NP), C‐terminal cross‐linked telopeptide of type‐I collagen (CTX) and parathyroid hormone (PTH) were lower at baseline and PTH, osteocalcin and P1NP were lower during the entire postprandial phase in participants with type 2 diabetes than in participants without type 2 diabetes. We observed similar postprandial responses in bone turnover markers between persons with and without type 2 diabetes. We observed no effect of the whey protein or the water pre‐meal on bone turnover markers. The changes were unrelated to secretion of hormones of the gut–bone axis.ConclusionOsteocalcin, P1NP, CTX and PTH all decreased following meal ingestion. We observed no convincing effect of a whey protein pre‐meal on bone turnover. However, these results confirm that people with type 2 diabetes have low bone turnover and that the decreased bone formation markers are also extend into the postprandial responses.