bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bromide impairs the circadian clock and glycolytic homeostasis via disruption of autophagy in rat H9C2 cardiomyocytes
Authors: Jiang Yicheng , Gu Yang , Xu Hai , Tian Xiaoyi , Zhang Xuefeng , Xu Xiaojin , Yan Wenting , Zhang Xiwen 
Published: June 2020

Abstract
Background
Trace elements function as essential cofactors that are involved in various biochemical processes in mammals. Autophagy is vital for nutrient supplement, which is an important Zeitegber for the circadian homeostasis in heart. Here, we considered the possibility that autophagy, as well as the cardiomyocyte clock and glycolysis are interlinked. Detrimental effects were observed when cardiac system is exposed to bromine containing drugs. This study investigated the effects and mechanisms of bromide on the circadian clock and glycolytic metabolism of H9C2 cardiomyocytes.

Results
In the present study, bromide does not affect cell viability and apoptosis of H9C2 cardiomyocytes. Bromide dampens the clock and glycolytic (Hk2 and Pkm2) gene expression rhythmicity in a dose-dependent manner. Additionally, bromide inhibits autophagic process in H9C2 cardiomyocytes. In contrast, rapamycin (an autophagy inducer) dramatically restores the inhibitory effect of NaBr on the mRNA expression levels of clock genes (Bmal1, Cry1 and Rorα) and glycolytic genes (Hk2 and Pkm2).

Conclusions
Our results reveal that bromide represses the clock and glycolytic gene expression patterns, partially through inhibition of autophagy.
The introduction of mindfulness groups to a psychiatric rehabilitation in-patient setting: a feasibility study
Authors: Millar Audrey , Tip Liesbeth , Lennon Ruth , Macinnes Marlene , Michalska Beata , Lawrie Stephen M , Schwannauer Matthias 
Published: June 2020

Abstract
Background
Patients within psychiatric rehabilitation services have multiple, complex and enduring difficulties, and are frequently described as ‘treatment resistant’. This group have diagnoses of major mental health conditions, most commonly schizophrenia, often alongside a history of complex trauma, co-morbid alcohol/ substance misuse, and cognitive impairment. There is no known effective medical treatment other than Clozapine in this patient group, however, there is preliminary evidence that mindfulness can help individuals with psychosis by improving their ability to cope with stressful internal experiences. This study aimed to determine if mindfulness practice groups are an acceptable therapeutic intervention in an in-patient rehabilitation setting. The study also aimed to monitor the well-being of those who participated.

Methods
Mindfulness practice groups were offered three times weekly on a 15-bedded rehabilitation ward in a psychiatric hospital over 5 months, and weekly in a second ward over an 18 month period. The sessions were delivered by Clinical Psychologists in accordance with adaptations for a psychosis population. Attendance data were gathered on both wards and additional measures of well-being were collected on one ward. Qualitative interviews were conducted with a sample of patients, group facilitators, and staff, to provide supplementary information about the acceptability of the intervention.

Results
In both wards around two thirds (65, 67%) of in-patients attended at least one group and smaller proportion (around a third) went on to attend regularly. There was no discernible impact on well-being using the Warwick-Edinburgh well-being scale. Qualitative interviews suggested a number of benefits to individuals attending as well as the potential for groups to enhance the therapeutic culture within wards.

Conclusions
Clinical guidelines suggest that all patients with a diagnosis of psychosis should have access to psychological therapies, but delivering psychological therapy within an in-patient rehabilitation setting can be challenging. This preliminary feasibility study suggests that mindfulness practice groups are an acceptable intervention, and that further research to look at the effectiveness of mindfulness for symptoms of treatment-resistant psychosis is both possible and merited.
Early upregulation of AR and steroidogenesis enzyme expression after 3 months of androgen-deprivation therapy
Authors: Hamid Agus Rizal A. H. , Kusuma Putra Harun W. , Sari Ningrum Paramita , Diana Putri , Sesari Saras Serani , Novita Eka , Gultom Fajar Lamhot , Saraswati Meilania , Tanurahardja Budiana , Asmarinah  , Umbas Rainy , Mochtar Chaidir A. 
Published: June 2020

Abstract
Background
Androgen deprivation therapy (ADT) is a standard treatment for advanced prostate cancer (PCa). However, PCa recurrence and progression rates during ADT are high. Until now, there has been no evidence regarding when progression begins. This study evaluated the gene expression of intraprostatic androgen receptor (AR) and steroidogenic enzymes in the early stages of ADT.

Methods
Prostate tissue samples were taken from PCa patients with urinary retention who received ADT (ADT-PCa; n = 10) and were further subgrouped into ADT ≤12 months (n = 4) and ADT > 12 months (n = 6). The ADT-PCa tissues were then compared with BPH (n = 12) and primary (no treatment) PCa tissues (n = 16). mRNA for gene expression analysis of AR and steroidogenic enzymes was extracted from formalin-fixed paraffin embedded (FFPE) tissues and analyzed by real-time PCR. Protein expression was evaluated by immunohistochemistry with specific antibodies.

Results
AR gene expression was higher in the ADT-PCa group than in the BPH or primary PCa group. Both the ADT ≤12 and > 12 months subgroups had significantly higher relative gene expression levels of AR (p < 0.01 and 0.03, respectively) than the primary PCa group. In the ADT-PCa group, AR protein expression showed an increasing trend in the ADT ≤12 months subgroup and was significantly elevated in the ADT > 12 months subgroup compared with the PCa group (100%; p < 0.01). Half (50%) of the patients in the ADT ≤12 months subgroup were found to have upregulation of AR, and one showed upregulation beginning at 3 months of ADT. A trend toward elevated relative gene expression of SRD5A3 was also apparent in the ADT groups.

Conclusion
AR and steroidogenic enzymes are upregulated in ADT-PCa patients as early as 3 months, without PSA elevation. Steroidogenic enzymes, particularly SRD5A3, were also upregulated before PSA rose.
Comparison of the effect of rapeseed oil or amaranth seed oil supplementation on weight loss, body composition, and changes in the metabolic profile of obese patients following 3-week body mass reduction program: a randomized clinical trial
Authors: Moszak Małgorzata , Zawada Agnieszka , Juchacz Aldona , Grzymisławski Marian , Bogdański Paweł 
Published: June 2020

Abstract
Background
Amaranth seed oil (ASO) and rapeseed oil (RSO) are functional foods that display antioxidant and hepatoprotective properties. These oils are also known to lower glucose and cholesterol levels. The current study compared the effects exerted by RSO and ASO on weight loss and metabolic parameters during a 3-week body mass reduction program.

Methods
Eighty-one obese subjects (BMI > 30 kg/m2), aged 25–70 years, were enrolled in a 3-week body mass reduction program based on a calorie-restricted diet and physical activity. Participants were randomly categorized into an AO group (administered 20 mL/d of ASO), a RO group (administered 20 mL/d of RSO), and a C group (control; untreated). Anthropometric and metabolic parameters were measured at baseline and endpoint.

Results
Significant decreases in weight, body mass index (BMI), waist circumference (WC), hip circumference (HC), fat mass (FM), lean body mass (LBM), visceral fat mass (VFM), and total body water (TBW%) were observed in all groups (P <  0.05). No significant improvements were observed in the clinical parameters of group C. Fasting insulin (Δ − 5.9, and Δ − 5.7) and homeostatic model assessment of insulin resistance (HOMA-IR) (Δ − 1.1 and Δ − 0.5) were decreased in both RO and AO groups, respectively. Fasting glucose (Δ -8.5; P = 0.034), total cholesterol (Δ -14.6; P = 0.032), non-HDL cholesterol (Δ 15.9; P = 0.010), TG/HDL ratio (Δ -0.6; P = 0.032), LDL cholesterol (Δ -12.3; P = 0.042), and triglycerides (Δ -6.5; P = 0.000) were significantly improved in the AO group, compared to the RO group.

Conclusions
The 3-week body mass reduction intervention caused a significant reduction in the weight, BMI, WC, HC, FM, and VFM of all groups. Except for HOMA-IR, there were no statistical differences between the clinical parameters of all groups. However, a trend toward improved insulin levels and HDL% was noticeable in AO and RO. Therapies involving edible oils with high nutritional value, such as RSO and ASO, show potential for improving metabolic measurements during body mass reduction programs. Thus, obese patients undertaking weight reduction programs may benefit from RSO and ASO supplementation.

Trial registration
retrospectively registered, DRKS00017708.
LAIR-1 overexpression inhibits epithelial–mesenchymal transition in osteosarcoma via GLUT1-related energy metabolism
Authors: Zhang Jinxue , Zhang Yuan , Cheng Shiyang , Mu Yang , Liu Yongming , Yi Xin , Jiang Dongxu , Ding Yong , Zhuang Ran 
Published: June 2020

Abstract
Background
Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is a collagen receptor belonging to the immunoglobulin superfamily. Although previous studies have evaluated the biological role of LAIR in solid tumors, the precise mechanisms underlying the functions of LAIR-1 as a regulator of tumor biological functions remain unclear.

Methods
LAIR-1 expression was evaluated by immunohistochemical analysis using an osteosarcoma (OS) tissue microarray. Wound healing and transwell migration assays were performed to evaluate tumor cell migration. Quantitative real-time polymerase chain reaction (qPCR) and western blotting were conducted to detect the expression of epithelial–mesenchymal transition (EMT)-related molecules. RNA-sequencing (RNA-seq) was conducted to evaluate the mRNA expression profiles after overexpressing LAIR-1 in OS cells. Glucose transporter (Glut)1 expression in OS cells was evaluated by western blotting.

Results
LAIR-1 expression was significantly different between the T1 and T2 stages of OS tumors, and it inhibited OS cell migration. LAIR-1 expression was inversely correlated with the expression of Twist1, an EMT-associated transcription factor, via the Forkhead box O1 signal transduction pathway. Furthermore, RNA-seq and qPCR demonstrated that the expression of EMT energy metabolism-related molecules was significantly reduced after LAIR-1 overexpression.

Conclusions
LAIR-1 overexpression decreased the expression of Glut1 and inhibited the expression of EMT-related molecules in OS cells. These findings provide new insights into the molecular mechanism underlying OS progression.
Neurological phenotypes in patients with NLRP3-, MEFV-, and TNFRSF1A low-penetrance variants
Authors: Mulazzani Elisabeth , Wagner Danny , Havla Joachim , Schlüter Miriam , Meinl Ingrid , Gerdes Lisa-Ann , Kümpfel Tania 
Published: June 2020

Abstract
Background
Neurological manifestations and the co-occurrence of multiple sclerosis (MS) have been reported in patients with autoinflammatory diseases (AID) and variants of the NLRP3-, MEFV-, or TNFRSF1A gene. However, type and frequency of neurological involvement are widely undetermined.

Methods
We assessed clinical characteristics of 151 (108 with MS) patients carrying NLRP3-, MEFV- and TNFRSF1A low-penetrance variants from the Institute of Clinical Neuroimmunology. We evaluated demographic, genetic, and clinical features with a focus on central nervous system (CNS) involvement including magnetic resonance imaging (MRI) results and cerebrospinal fluid (CSF) data. The disease course of AID patients with MS was compared to a matched MS control group without mutations.

Results
The genetic distribution comprised 36 patients (23%) with NLRP3- and 66 patients (43%) with TNFRSF1A low-penetrance variants as well as 53 (34%) patients carrying pathogenic mutations or low-penetrance variants in the MEFV gene. MS patients displayed most frequently the R92Q TNFRSF1A variant (n = 51; 46%) followed by the Q703K NLRP3 variant (n = 15; 14%) and the E148Q substitution (n = 9; 8%) in the MEFV gene. The disease course of MS was not influenced by the genetic variants and did not differ from MS patients (n = 51) without mutations. AID patients without MS most frequently harbored MEFV mutations (n = 19, 43%) followed by NLRP3- (n = 17, 39%) and TNFRSF1A (n = 8, 18%) low-penetrance variants. Sixteen (36%) of them suffered from severe CNS involvement predominantly recurrent aseptic meningoencephalitis and optic neuritis accompanied by abnormal MRI and CSF results. Severe CNS inflammation was associated with the Q703K allele. Headache was a highly prevalent neurological symptom (up to 74%), irrespective of the underlying genetic variation. The NLRP3 cohort without MS more frequently exhibited affections of the cranial nerves (CN) (p = 0.0228) and motor symptoms (p = 0.0455). Elevated acute-phase reactants were detected in all patients, and fever episodes were present in up to 50%. Arthralgias were the most frequently identified constitutional symptom among all subgroups.

Conclusions
Our data highlight the high prevalence of neurological manifestations, including concomitant MS, among NLRP3-, MEFV-, and TNFRSF1A low-penetrance variants. In particular, patients carrying the Q703K NLRP3 variant are at risk for severe CNS inflammation and CN affection.
On a fractional hybrid version of the Sturm–Liouville equation
Authors: Charandabi Zohreh Zeinalabedini , Rezapour Shahram , Ettefagh Mina 
Published: June 2020

AbstractIt is well known that the Sturm–Liouville equation has many applications in different areas of science. Thus, it is important to review different versions of the well-known equation. The technique of α-admissible α-ψ-contractions was introduced by Samet et al. in (Nonlinear Anal. 75:2154–2165, 2012). Our aim in this work is to study a fractional hybrid version of the Sturm–Liouville equation by mixing the technique of Samet. In fact, by using the technique of α-admissible α-ψ-contractions, we investigate the existence of solutions for the fractional hybrid Sturm–Liouville equation by using the multi-point boundary value conditions. Also, we review the existence of solutions for a fractional hybrid version of the problem under the integral boundary value conditions. Finally, we provide two examples to illustrate our main results.
More properties of the proportional fractional integrals and derivatives of a function with respect to another function
Authors: Jarad Fahd , Abdeljawad Thabet , Rashid Saima , Hammouch Zakia 
Published: June 2020

AbstractIn this article, we present some new properties of the fractional proportional derivatives of a function with respect to a certain function. We use a modified Laplace transform to find the relation between the derivatives in the Riemann–Liouville setting and the one in Caputo. In addition, we provide an integration by parts formulas related to the considered operators.
Pre-operative predicting factor in visual outcome after macular hole surgery
Authors: Feroz Lubna , Rizvi Syed Fawad , Naz Saliha , Khan Tanweer Hassan 
Published: June 2020

Objective: To determine the effectiveness of macular hole index (MHI) as a predicting factor of visual outcome after full thickness macular hole surgery.
Methods: This quasi-experimental study was conducted at LRBT Free Base Eye Hospital, Karachi from January 2018 to March 2019. Total 45 eyes of 45 patients with full thickness macular hole (FTMH) underwent preoperative Best Corrected Visual Acuity (BCVA) assessment with logMar chart and Optical Coherence Tomography (OCT) scanning, with measurement of base diameter and macular hole height. Values were calculated for the macular hole index (MHI), which was taken as the predictive factor. All patients had undergone 25+G trans-conjunctival three ports pars plana vitrectomy, internal limiting membrane peeling, and endo-tamponade of C3F8 (14%). The final visual outcome of all the patients was noted.
Results: Forty-five patients were included for the study, out of which 10 (22.2%) were male and 35 (77.7%) were female. Age ranged from 45-70 years (mean age 57.20±6.47 years). The mean pre-operative visual acuity was 2.46±1.15 logMar and was 3.88±2.00 logMar, post-operatively. Moreover, 27(60.0%) out of 45 patients achieved BCVA (gain of 2 lines of the logMar chart). The average macular hole index was 1.55±0.50 and out of 45, 25 patients had MHI ≥0.5. It was found that patients with macular hole index ≥0.50 showed clinically significant improvement in BCVA in comparison to those who have macular hole index <0.50.
Conclusion: Macular hole index can be used to predict functional success in macular hole surgery.
doi: https://doi.org/10.12669/pjms.36.5.1995
How to cite this:Feroz L, Rizvi SF, Naz S, Khan MTH. Pre-operative predicting factor in visual outcome after macular hole surgery. Pak J Med Sci. 2020;36(5):1053-1057. doi: https://doi.org/10.12669/pjms.36.5.1995
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
When Will Workers Follow an Algorithm? A Field Experiment with a Retail Business
Authors: Kawaguchi Kohei 
Published: June 2020

This paper develops a new algorithm for increasing the revenue in a dynamic product assortment problem. Then, it identifies the challenges faced by managers in practice and discusses the conditions under which workers follow the algorithm. To do so, I conducted a field experiment with a beverage vending machine business. The experiment shows that, on average, workers are reluctant to follow the algorithmic advice; however, the workers are more willing to conform once their forecasts are integrated into the algorithm. Analyses using nonexperimental variations highlight the importance of taking worker and context heterogeneity into account to maximize the benefit from adopting a new algorithm. Higher worker’s regret, sales volatility, and fewer delegations increase the conformity, while they mitigate the effects of integration. Workers avoid high-traffic vending machines and focus on machines with high sales volatility when adopting the algorithm. The effects on the sales are largely similar to the effects on product assortments. The results emphasize the gap between nominal and actual performance of an algorithm and several practical issues to be resolved. This paper was accepted by Matthew Shum, marketing.
A disputa de Davos entre Ernst Cassirer e Martin Heidegger
Authors: Heidegger Martin , Cassirer Ernst 
Published: June 2020

Apresentamos a tradução para a língua portuguesa do “Debate de Davos entre E. Cassirer e M. Heidegger”, ocorrido em 26 de março de 1929. A versão aqui traduzida se baseou na transcrição do original alemão, realizada por Joaquim Ritter e Friedrich Bollnow. Tradução de Adriano Ricardo Mergulhão
LEITURAS DO PODER NA TERCEIRA ERA DA TERRA-MÉDIA: UM ENSAIO BASEADO EM O SENHOR DOS ANÉIS
Authors: Da Silva Nunes Rafael 
Published: June 2020

O imaginário se estabelece como um campo fértil para o pensamento das múltiplas relações existentes e experienciadas pela realidade humana. Questões associadas à discussão socioeconômica, física, biótica, política, entre outras, podem ser exploradas a partir de construções que possuem, por base, a imaginação. Neste caso, a literatura surge como um dos instrumentos de representação de realidades (des)conhecidas passíveis de serem lidas sob as múltiplas óticas supracitadas. A obra de J. R. R. Tolkien intitulada de “O Senhor dos Anéis” se apresenta como um arquétipo de uma imaginação complexa na qual diferentes sociedades são apresentadas, relacionando-se interna e externamente de múltiplas maneiras. A obra, a partir da sua própria complexidade, apresenta-se como um excelente palco para o desenvolvimento de inúmeros ensaios sobre diferentes esferas que envolvem a própria percepção humana da realidade. Uma das esferas mais discutidas na obra de Tolkien refere-se à dinâmica do poder que pode ser observado na política entre as múltiplas sociedades existentes na Terra-Média. Neste sentido, o objetivo do presente estudo é analisar, a partir dessa obra, como o poder é encarado por seus múltiplos personagens (e sociedades), bem como compreender que dinâmica possibilitou o surgimento do poder político na Terra-Média.
High gain amplification up to 100  mJ to 3  J using Yb3+:YAG slab-based cat’s-eye cavities under variable seed and operating conditions
Authors: Jolly A. , Machinet G. , Boullet J. 
Published: June 2020

We demonstrate the optical architecture of a fairly compact design at 1030 nm for linear amplification, which enables the combination of very high gains and output energies in a single stage to be operated at room temperature. Gains and energies are experienced in the nanosecond regime up to 20 dB and 120 mJ, respectively, at the same time. This design makes use of a thick slab of

Y

b

3
+

:

Y
A
G

in a scalable cat’s-eye cavity, provided there is uniform edge-pumping and fine control of a number of relevant spatial characteristics regarding the pump and the cavity. Highly variable operating conditions are considered for a comprehensive benchmark of the optical performance. They involve single 3 ns long seed pulses with an energy of 1 mJ, accordingly to more or less gain saturation, together with long bursts of stretched picosecond-long pulses. This gives access to kilowatt-class pulse trains of duration 3–5 ms, with a total energy of up to 3 J and an optical efficiency of 20%–25%, prior to more complete gain saturation.
Actual decomposition of the L2 French noun phrase in the predicate construction in the final written examination
Authors: Kazlauskienė Vitalija 
Published: June 2020

The noun phrase (NP), one of the key elements of a sentence, can reveal the characteristics of a learner’s linguistic competence. The present study focuses on actual decomposition of NP in the predicate construction. This is when the attribute elements of a noun phrase are included in the predicate construct as factor-actualized determinants. In this position, the copula verb is merely a grammatical means of allowing the attribute to become a predicate (Gaulmyn, Basset 1991: 177).The aim of the study being a more thorough investigation of the criteria and peculiarities of producing this type of predicate constructs in learner language, the present research is based on the empirical material from the Lithuanian learner corpus. The paper briefly discusses the concept of the predicate construction and describes the process of compiling the learner corpus as well as the principles of data selection. The analysis of the NP in a predicate construction is then presented, and the characteristic cases from the corpus data are examined. The main limitation of the present study is related to the scope of the learner corpus. Having summarized the results of the quantitative and qualitative research, the following conclusions were formulated. The learner language is dominated by NP predicate constructions with an adjective more often than a noun. As to the verb conjunction, the typical attribute verb être ‘to be’ was the only one widely used in the corpus under investigation. The analysis of the corpus data also revealed a number of specific errors that are typical of the learners’ written language. In general, the predictive constructions in the learners’ language are characterized by the omission of redundancy tags in the grammatical categories of gender and number. The analysis of the learner corpus provided a broader look at the NP in a predicate construction, highlighting the simplicity, conciseness and repetition of this construct. The results of the study are important for a more comprehensive description of the learners’ language, for solving problems in foreign language analysis, and for contributing to the quality of teaching and learning the French language.