bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polyurethane Meniscal Scaffold: Does Preoperative Remnant Meniscal Extrusion Have an Influence on Postoperative Extrusion and Knee Function?
Authors: Gelber Pablo E. , Torres-Claramunt Raúl , Poggioli Francesco , Pérez-Prieto Daniel , Monllau Joan C. 
Published: May 2020

AbstractMeniscal extrusion (ME) has been identified as a risk factor in the development of knee osteoarthritis. The relevance of this finding when a meniscal scaffold is used has not been extensively studied. The objective of this study was to determine whether preoperative meniscal remnant extrusion (MRE) was correlated with postoperative scaffold extrusion (SE) or with functional outcomes at the 2-year follow-up. Retrospective study included all polyurethane scaffolds implanted with a minimum 2-year follow-up. A magnetic resonance imaging (MRI) was performed preoperatively and postoperatively at 2 years. Extrusion was measured in millimeters in a coronal view. Patients were assigned to either group 1 or 2 depending on the preoperative MRE being either <3 mm (minor extrusion) or 3 mm (major extrusion). Functional outcomes were analyzed by means of the Western Ontario Meniscal Evaluation Tool (WOMET), International Knee Documentation Committee, Kujala and Tegner scores, as well as visual analog scale. Satisfaction was also documented. Sixty-two out of 98 patients were available to undergo an MRI at final follow-up. The mean age was 41.3 years (range, 17–58) and the mean follow-up was 45 months (range, 25–69). The mean preoperative MRE was 2.8 mm (standard deviation [SD] 1.2) and the mean postoperative SE was 3.8 mm (SD 1.8) (p < 0.01). All functional scores improved during the study period. When the correlation (Spearman's rho) between the difference in extrusion between the pre 26 and postoperative periods and their correlation with the different scores was assessed, correlation was only observed in the WOMET (rho 0.61, p = 0.02). The preoperative MRE in Group 1 was 1.85 mm (SD 0.83) and 3.7 mm (SD 2.2) in Group 2 (p < 0.01). At final follow-up, SE was 3.86 mm (SD 0.7) in Group 1, whereas it was 3.98 mm (SD 1) in Group 2 (p = 0.81). No differences were observed in the scores used for these two groups. The SE observed at the 2-year follow-up after the implantation of a polyurethane scaffold did not depend on preoperative MRE (major or minor extrusion). The WOMET score, which was the only meniscal-specific functional scored used, showed some inferior results in the most extruded meniscal scaffolds. This is a retrospective case series. Level of evidence is 4.
Genomics and Interventional Oncology in Metastatic Liver Cancer
Authors: Dendy Case Meaghan , Slovak Ryan , Kim Hyun S. 
Published: May 2020

AbstractThis review aims to investigate the current literature on genetic and genomic biomarkers of locoregional interventions on metastatic liver metastases. A brief overview on the most common cancers that metastasize to the liver and the role locoregional therapies, such as ablation, chemoembolization, and radioembolization, play in their treatment will be presented. Review of the literature on the genetic, metabolic, and other molecular biomarkers and how they relate to posttreatment survival and outcomes will be discussed. Evaluation of how the existing data can better inform decisions regarding locoregional treatments in those patients with metastatic lesions of the liver will be completed. Personalized treatment paradigms in different types of metastatic cancer present significant opportunities for improved overall clinical outcomes. Optimizing patient selection for localized treatments is vital to improving outcomes and determining which biomarkers correlate with improved efficacy presents many avenues for future research.
Carelign: A Novel Handoff System for Medical and Surgical Consultants
Authors: Shafer Brian Michael , Gorry Thomasine , Tapino Paul , Airan-Javia Subha 
Published: May 2020

Abstract
Background Patient handoffs are ubiquitous in hospital settings. Historically, formal handoffs of patient information have been conducted in the inpatient setting mainly by primary teams, as opposed to medical and surgical consultants. Carelign is a software developed by the University of Pennsylvania Health System to function as an interdisciplinary, patient-centered handoff. While mainly utilized by primary teams for work management and transitions, it has been enhanced to include specialty consultant handoff functionality.
Objective The aim of this study is to determine whether using Carelign for consultant handoffs improves clinical handoffs in comparison to the prior handoff system (a custom-built handoff report within the electronic health record) used by the Department of Ophthalmology at Penn Presbyterian Medical Center.
Methods A 7-item questionnaire assessing the effectiveness, efficiency, accessibility, reliability, communication, and security of the handoff using a 1 to 5 scale was distributed to residents prior to and 6 months subsequent to the implementation of Carelign.
Results Users reported a statistically significant increase in Health Insurance Portability and Accountability Act (HIPPA)-compliance (44 vs. 100%, p < 0.0001) and ability to communicate with primary teams (38 vs. 70%, p = 0.019) after implementation of Carelign. There was a trend toward significance with ease of accessing information after switching to Carelign (67 vs. 85%, p = 0.185). There was no statistically significant difference in effectiveness, efficiency, accessibility from home, or reliability of information on handoff after converting to the new system.
Conclusion Carelign is perceived to be an effective tool that can be used by consulting providers to ensure HIPPA-compliance and the ability to communicate with primary teams without sacrificing effectiveness, efficiency, accessibility, or reliability.
Conversational narrative marker1
Authors: Zhu Dongyi 
Published: May 2020

Abstract
This study presents a corpus-based analysis of the pragmatic
identification and functional modification of Chinese conversational narrative
marker (henceforth CNM). Adopting a three-dimensional design from
pragmatic-semantic-cognitive views of CNM, the present study proposes that a CNM
is a linking device establishing the narrator’s subjective attitude to introduce
his/her narrative intent. The study has extracted “ranhou” from
the author’s self-constructed Chinese conversational narratives corpus, which
comprises 15 pieces of casual talks by 38 adult native speakers of Chinese. The
study has found that (1) semantically, CNM holds the cohesion-oriented function
for introducing referential default and semantic default; (2) pragmatically, CNM
plays an interactive role between the discourse sequentiality and contextual
inference demonstrating the economy of language and salience of semantic
representation; (3) cognitively, the intentional cognitive cooperation between the
narrator and the listener have been revealed by CNM.
Language resources of Yunnan in “the Belt and Road” project
Authors: Tsung Linda , Xia Zhang , Zhang Lubei 
Published: May 2020

Abstract
As a multi-ethnic and multilingual province, Yunnan has very
rich resources in the minority languages. Among the 25 ethnic minority groups, 22
groups speak 26 languages, belonging to the Tibetan-Burmese, Zhuang-Dong, Miao Yao
and Meng Khmer language branches of the two major language families of
Sino-Tibetan and Austro-Asiatic. The 16 cross-border ethnic groups are mainly
distributed outside in Vietnam, Laos, Myanmar and other countries bordering China.
The languages and characters of these cross-border ethnic groups have become
important language resources in Yunnan in the construction of “Belt and Road
Initiative”. How to fully develop and make full use of these languages to meet the
language needs of ethnic groups in these countries along the route and to achieve
cooperation and win-win results under the framework of equal language and cultural
identity is an urgent problem to be studied and solved by the Chinese government.
This paper will make an in-depth analysis of the current language policy in Yunnan
and its efforts in the protection of cross-border language resources, in the hope
to provide some ideas for the scientific protection and utilization of
cross-border language resources.
Physical activity, use of alcohol and smoking in middle‐aged and aging men. A longitudinal study among Finnish male former athletes and controls
Authors: Kontro Titta K. , Tolvanen Asko , Sarna Seppo , Kaprio Jaakko , Kujala Urho M. 
Published: May 2020

AbstractIt is not known whether decrease in physical activity (PA) is associated with binge drinking among former athletes. The purpose of this study was to investigate the reciprocal associations between PA and use of alcohol among former athletes and controls at four time points. Furthermore, we examined whether there were longitudinal latent profiles related to use of alcohol, smoking and PA during the follow‐up. Finnish male former elite athletes (n = 1633) and matched controls (n = 1099) questionnaire‐reported their PA, alcohol consumption and smoking at four time points in 1985, 1995, 2001 and 2008. Former athletes were more physically active and smoked less than controls, but in all profiles smoking decreased during the follow‐up. Former athletes consumed alcohol significantly more compared to controls in 1985, especially if their athletic career had ended suddenly by sports injury. At other time points, no differences were seen. Five latent profiles were found, and there were significant differences between former athletes and controls in the probabilities to belong to four of them. PA decreased in four of five profiles, while alcohol consumption decreased or increased in some profiles. But PA did not predict later alcohol consumption at any time point. Cross‐lagged path model indicated that the mutual associations of alcohol use and PA were weak at most. Although risk of excessive alcohol consumption may increase in individuals, whose athletic career has ended suddenly by sports injury, overall PA and alcohol affected each other's development only modestly among former athletes and controls during the 23‐year follow‐up.
Transformational parenting and coaching on mental toughness and physical performance in adolescent soccer players: The moderating effect of athlete age
Authors: Murray Ross M. , Dugdale James H. , Habeeb Christine M. , Arthur Calum A. 
Published: May 2020

AbstractBoth parent and coach leadership behaviours are instrumental to adolescent athlete development. Researchers, however, are yet to examine parent and coach leadership influences simultaneously, and at different stages of adolescents’ psychological and physical development. Therefore, the purpose of this study was to understand if the effects of transformational parenting, and transformational coaching on mental toughness and performance varied at different ages during adolescence. Early adolescent (ages 10–14) and late adolescent (ages 15–18) soccer players (n = 334) completed questionnaires assessing their perceptions of their mother's, father's, and coach's transformational leadership, as well as a questionnaire assessing mental toughness. Participants also completed a comprehensive battery of physical fitness tests relevant to soccer. Results indicated that transformational fathering was more strongly associated with levels of mental toughness for early adolescent athletes than it was for later adolescent athletes. Results also indicated that transformational coaching was more strongly associated with physical performance for later adolescent athletes than it was for early adolescents. Overall, these results can inform development models and provide support for future longitudinal studies to assess the impact of parent and coach transformational leadership across different stages of athlete development.
Small extracellular vesicles modulated by αVβ3 integrin induce neuroendocrine differentiation in recipient cancer cells
Authors: Quaglia Fabio , Krishn Shiv Ram , Daaboul George G. , Sarker Srawasti , Pippa Raffaella , Domingo‐Domenech Josep , Kumar Gaurav , Fortina Paolo , McCue Peter , Kelly William K. , Beltran Himisha , Liu Qin , Languino Lucia R. 
Published: May 2020

ABSTRACTThe ability of small extracellular vesicles (sEVs) to reprogram cancer cells is well established. However, the specific sEV components able to mediate aberrant effects in cancer cells have not been characterized. Integrins are major players in mediating sEV functions. We have previously reported that the αVβ3 integrin is detected in sEVs of prostate cancer (PrCa) cells and transferred into recipient cells. Here, we investigate whether sEVs from αVβ3‐expressing cells affect tumour growth differently than sEVs from control cells that do not express αVβ3. We compared the ability of sEVs to stimulate tumour growth, using sEVs isolated from PrCa C4‐2B cells by iodixanol density gradient and characterized with immunoblotting, nanoparticle tracking analysis, immunocapturing and single vesicle analysis. We incubated PrCa cells with sEVs and injected them subcutaneously into nude mice to measure in vivo tumour growth or analysed in vitro their anchorage‐independent growth. Our results demonstrate that a single treatment with sEVs shed from C4‐2B cells that express αVβ3, but not from control cells, stimulates tumour growth and induces differentiation of PrCa cells towards a neuroendocrine phenotype, as quantified by increased levels of neuroendocrine markers. In conclusion, the expression of αVβ3 integrin generates sEVs capable of reprogramming cells towards an aggressive phenotype.
Comprehensive Comparison Between Shaped Versus Round Implants for Breast Reconstruction: A Systematic Review and Meta-Analysis
Authors: Han So-Eun , Lee Kyeong-Tae , Bang Saik 
Published: May 2020

Abstract

Background
Prosthetic breast reconstruction has been gaining popularity and a variety of implant options are currently available. Therefore, it is important to evaluate the safety and efficacy of newly developed shaped implants compared with those of conventional round implants. To date, few studies have investigated the outcomes of breast reconstruction with shaped versus round implants.

Objectives
The present study aimed to comprehensively compare, via meta-analytic methodology, shaped and round breast implant reconstruction in terms of complication profiles and aesthetic satisfaction.

Methods
PubMed/MEDLINE, Ovid, and Cochrane databases were searched to identify relevant studies presenting the complication rates for shaped and round implant groups. The relative risks of the following complications between the groups were calculated: infection, seroma, capsular contracture, rupture, rippling, reconstruction failure, and implant exchange or removal. Outcomes of aesthetic satisfaction included aesthetic results and patient-reported outcomes.

Results
Meta-analysis of 8 retrospective cohort studies, representing 2490 cases of implant-based breast reconstruction, was performed. There were no significant differences in the risks of infection, seroma, capsular contracture, and reconstruction failure between the 2 groups. The risks of implant rupture and rippling were significantly reduced with shaped implants. In a subgroup analysis of shaped/textured and round/smooth implants, the risk of infection was significantly enhanced in the former, whereas incidences of other complications, including capsular contracture and reconstruction failure, were similar. Aesthetic satisfaction analysis of the 2 groups demonstrated similar outcome scores with favorable overall results.

Conclusions
Our results suggest that both shaped and round implants might provide favorable breast reconstruction outcomes with similarly low complication rates and aesthetic results.

Level of Evidence: 4
A comprehensive integrated drug similarity resource forin-silicodrug repositioning and beyond
Authors: Azad A K M , Dinarvand Mojdeh , Nematollahi Alireza , Swift Joshua , Lutze-Mann Louise , Vafaee Fatemeh 
Published: May 2020

AbstractDrug similarity studies are driven by the hypothesis that similar drugs should display similar therapeutic actions and thus can potentially treat a similar constellation of diseases. Drug–drug similarity has been derived by variety of direct and indirect sources of evidence and frequently shown high predictive power in discovering validated repositioning candidates as well as other in-silico drug development applications. Yet, existing resources either have limited coverage or rely on an individual source of evidence, overlooking the wealth and diversity of drug-related data sources. Hence, there has been an unmet need for a comprehensive resource integrating diverse drug-related information to derive multi-evidenced drug–drug similarities. We addressed this resource gap by compiling heterogenous information for an exhaustive set of small-molecule drugs (total of 10 367 in the current version) and systematically integrated multiple sources of evidence to derive a multi-modal drug–drug similarity network. The resulting database, ‘DrugSimDB’ currently includes 238 635 drug pairs with significant aggregated similarity, complemented with an interactive user-friendly web interface (http://vafaeelab.com/drugSimDB.html), which not only enables database ease of access, search, filtration and export, but also provides a variety of complementary information on queried drugs and interactions. The integration approach can flexibly incorporate further drug information into the similarity network, providing an easily extendable platform. The database compilation and construction source-code has been well-documented and semi-automated for any-time upgrade to account for new drugs and up-to-date drug information.
scCancer: a package for automated processing of single-cell RNA-seq data in cancer
Authors: Guo Wenbo , Wang Dongfang , Wang Shicheng , Shan Yiran , Liu Changyi , Gu Jin 
Published: May 2020

AbstractMolecular heterogeneities and complex microenvironments bring great challenges for cancer diagnosis and treatment. Recent advances in single-cell RNA-sequencing (scRNA-seq) technology make it possible to study cancer cell heterogeneities and microenvironments at single-cell transcriptomic level. Here, we develop an R package named scCancer, which focuses on processing and analyzing scRNA-seq data for cancer research. Except basic data processing steps, this package takes several special considerations for cancer-specific features. Firstly, the package introduced comprehensive quality control metrics. Secondly, it used a data-driven machine learning algorithm to accurately identify major cancer microenvironment cell populations. Thirdly, it estimated a malignancy score to classify malignant (cancerous) and non-malignant cells. Then, it analyzed intra-tumor heterogeneities by key cellular phenotypes (such as cell cycle and stemness), gene signatures and cell–cell interactions. Besides, it provided multi-sample data integration analysis with different batch-effect correction strategies. Finally, user-friendly graphic reports were generated for all the analyses. By testing on 56 samples with 433 405 cells in total, we demonstrated its good performance. The package is available at: http://lifeome.net/software/sccancer/.
A case of recurrent takotsubo-like cardiomyopathy associated with pheochromocytoma exhibiting different patterns of left ventricular wall motion abnormality and coronary vasospasm: a case report
Authors: Sato Koichi , Takahashi Jun , Amano Keiko , Shimokawa Hiroaki 
Published: May 2020

AbstractBackgroundTakotsubo-like cardiomyopathy associated with pheochromocytoma (Pheo-TTS) is a recognized but uncommon disorder. While Pheo-TTS might more often recur and the pattern of left ventricular (LV) wall motion abnormality is more diverse compared with primary TTS, it remains to be elucidated whether coronary functional abnormalities are also involved.Case summaryA 50-year-old woman was referred with a chief complaint of transient chest pain, dyspnoea, and paroxysmal thyroid swelling that usually developed after meals. In the past, she had been admitted to emergency rooms three times due to pulmonary oedema following the above attacks. Serial cardiac catheterizations showed normal coronary arteries and morphologically different types of LV dysfunction each time; apical LV ballooning at the first, basal LV ballooning at the second, and diffuse LV hypokinesis at the last admission. Acetylcholine (ACh) provocation testing for coronary vasospasm was negative at the second admission. During hospitalization in our department, abdominal ultrasonography for screening detected a right adrenal mass and the urinary normetanephrine level was increased. The adrenal tumour was urgently removed surgically and finally she was diagnosed as having norepinephrine-secreting pheochromocytoma. Acetylcholine testing was again performed just after the operation, showing both epicardial and microvascular coronary spasms. Since the operation, she has been free of symptoms. Importantly, ACh testing at 1-year follow-up showed that epicardial spasm was no longer noted, whereas coronary microvascular spasm persisted.DiscussionAdrenal pheochromocytoma could cause recurrent attacks of catecholamine surges with different patterns of LV dysfunction, where coronary vasospasm may also be involved along the coronary arteries.
The Human Right to Science and Its Relationship to International Environmental Law
Authors: Hubert Anna-Maria 
Published: May 2020

Abstract
This article explores the potential contribution of international human rights law – specifically, the oft-neglected ‘right to science’ – to the interpretation, operation and progressive development of international environmental law. Science and its applications play a critical role in environmental protection. At the same time, society faces persistent controversies at this interface. Environmental regimes may lack sufficient norms and tools for regulating upstream science and innovation processes because they tend to focus narrowly on physical harms to the environment and may not address the wider ethical, legal, social and political concerns. The human right to science, which is codified in various international and regional human rights instruments, may serve to augment international environmental law and contribute to more effective, equitable and democratically legitimate and accountable processes and outcomes in relation to the application of science and technology in environmental regimes. The article begins by outlining the scope and contents of, as well as the limitations on, the right to science, focusing on Article 15(1)(b) of the International Covenant on Economic, Social and Cultural Rights (ICESCR) and its overlaps with the norms of international environmental law.1 It then analyses the ways in which the right to science may influence the development of international environmental law by elucidating mechanisms for the integration of a human rights perspective in science and technology and by outlining its potential substantive contributions to the development of international environmental law.