bluuebunny/crossref_metadata_2025_split huggingface dataset:
Probióticos na redução de sintomas de ansiedade e depressão: uma revisão integrativa
Authors: Costa Bruna Cunha , Azevedo George Silva dos Santos , Ferreira Pedro Henrique Arruda , Rodrigues Almeida Leila Magda 
Published: December 2020

Objetivos: sumarizar estudos que avaliaram a suplementação de probióticos como estratégia terapêutica nos sintomas da ansiedade e depressão. Métodos: revisão integrativa de artigos indexados na base de dados PubMed, SciELO e Biblioteca Virtual em Saúde publicados de janeiro de 2010 a setembro de 2019. Para isso, utilizou-se a conjugação dos descritores: “intestino”, “cérebro”, “microbiota intestinal”, “ansiedade”, “depressão”, “probióticos”, nos idiomas português e inglês. Resultados: Após a aplicação dos critérios de inclusão e exclusão, 13 ensaios clínicos randomizados foram selecionados. O tempo de duração dos estudos, em sua maioria, foi de 8 ou 12 semanas (61,5%; n = 8), e a forma mais ofertada do suplemento foi o probiótico em pó (46,2%; n = 6) e em cápsula (30,8%; n = 4). Sobre a utilização de escalas como parâmetro de avaliação dos sintomas de ansiedade e depressão, 38,5% (n = 5) utilizaram apenas uma escala e 69,2% (n = 8) utilizaram a combinação de duas ou três escalas. Em relação ao gênero das bactérias, a maior parte dos estudos utilizou Lactobacillus e Bifidobacterium em conjunto (53,8%; n = 7). Apesar das limitações metodológicas e dos resultados inconsistentes, a maioria dos ensaios clínicos (76,9%; n = 10) evidenciaram uma redução significativa dos sintomas relacionados à ansiedade e depressão através da suplementação de probióticos. Conclusão: As evidências indicam que a suplementação com probióticos apresenta potencial promissor na redução dos sintomas de ansiedade e depressão, no entanto são necessárias pesquisas adicionais sobre essa estratégia como terapia adjuvante no tratamento efetivo para a saúde mental.
The effectiveness of a smartphone-based online peer group on type II diabetes mellitus patients self-empowerment in a primary healthcare center in Indonesia
Authors: Rosyida Ratna Wirawati , Pertiwi Ariani Arista Putri , Pangastuti Heny Suseani 
Published: December 2020

Objective: Self-empowerment is an important factor that influences a person's ability to perform effective diabetes management. One effort that can be done to improve self-empowerment is by providing a smartphone-based online peer-group. This research determined the effect of smartphone-based online peer groups on type 2 diabetes mellitus (T2DM) patients self-empowerment in four primary healthcare centers in Indonesia. Methods: This quasi-experimental research was conducted in four healthcare centers in Indonesia. The total sample was 71 divided into two groups (control and intervention). The control group received standard education from the healthcare center, whereas the intervention group underwent an online peer-group. Self-empowerment was measured before and after intervention using the Diabetes Empowerment Scale-Short Form (DES-SF) questionnaire (Indonesian version). General Linear Model was used in statistical analysis. Results: The mean age of respondents was 56.4 ± 8.8 and 56.9 ± 7.1 years old, 59.5%, and 76.5% had good family support, and 70.3% and 50% of respondents had not received diabetes education for the control and intervention groups, respectively. The average pretest self-empowerment score was 27.03 ± 3.73 and 27.59 ± 3.53 (diff. 0.56; 95%CI -1.16; 2.29), and the post-test score was 27.43 ± 4.13 and 32.76 ± 4.38 (diff. 5.33; 95%CI 3.32; 7.35) for the control and intervention groups, respectively. Online peer-group improve self-empowerment significantly in the intervention group. Conclusion: Smartphone-based online peer-group can improve self-empowerment in patients with T2DM.
Reformasi Hukum dan Realisasi Investasi Asing pada Era Presiden Joko Widodo
Authors: Sutrisno Nandang , Poerana Sigar Aji 
Published: December 2020

This article discusses two reasearch questions, firstly, whether law reforms on investment by the issuance of policy packages involving massive numbers of regulations during the First Period of President Jokowi have been successful to increase the realization of foreign investments? Secondly, how is the projection of foreign investment policies in the Second Period Of President Joko Widodo to increase the realization of foreign investments? Theoretical framework used in this article methodologically places law as external environment for foreign investors, and that law is the priority factor and the most relevant for investment and economic growth. This article concludes that first, law reforms on investments by the issuance of massive regulations in the First Period, even though having been successful to increase the values of realization of cumulative foreign investments significantly, they have been unsuccessful in increasing the annual percentages of foreign investment growth. Second, Omnibus Law and the then implementing regulations that would be used to increase foreign investments have been inviting resistances from various components of the nation, due to lack of transparent procedures and degrading the interests of public at large, and bias of the intersets of investors. Therefore, the effectiveness of law reforms in the Second Period would be impeded by various resistant movements, and in turn, be contraproductive with the purposes of legal reforms.
Abstrak
Artikel ini membahas dua permasalahan utama, pertama apakah reformasi hukum investasi melalui serangkaian paket kebijakan dengan jumlah peraturan yang masif pada Periode Pertama Presiden Jokowi telah berhasil meningkatkan realisasi investasi asing? Kedua, bagaimanakah proyeksi kebijakan investasi asing pada Periode Kedua Presiden Jokowi untuk meningkatkan realisasi investasi asing? Kerangka teoretik yang digunakan dalam artikel ini secara metodologis menempatkan hukum sebagai lingkungan eksternal dari investasi asing, bahwa hukum merupakan faktor prioritas dan paling relevan untuk investasi dan pertumbuhan ekonomi. Kesimpulan dari artikel ini pertama, reformasi hukum investasi dengan mengeluarkan produk hukum yang masif pada Periode Pertama meskipun berhasil meningkatkan nilai investasi asing kumulatif secara signifikan, tetapi tidak berhasil meningkatkan persentase pertumbuhan pertahunnya. Kedua, Omnibus Law dan peraturan-peraturan pelaksanaanya yang akan diandalkan untuk meningkatkan investasi asing telah mengundang resistensi dari berbagai komponen bangsa, karena secara prosedur pembentukannya tidak transparan dan secara substantif mendegradasi kepentingan masyarakat luas serta lebih berpihak kepada kepentingan para investor. Dengan demikian efektivitas reformasi hukum pada Periode Kedua akan terganggu dengan berbagai gerakan resistensi yang akan menyebabkan kontraproduktif dengan tujuan dari reformasi hukum tersebut.
Aktualisasi Pancasila sebagai Sumber Hukum dalam Pembentukan Undang-Undang
Authors: Arfa'i Arfa'i , Nasution Bahder Johan , Febrian Febrian 
Published: December 2020

In the Indonesian legal system, Pancasila is the source of all sources of law, the basis of the national law, and functions as rechtsidee. With such a position, all positive laws should reflect and be in line with Pancasila values. This article aims at exploring how Pancasila values actualized in the legislation of law. This article demonstrates that despite the vital role of Pancasila as long the legislation of law is concerned, there are no clear indicators and variables indicating that a law has reflected and been in line with Pancasila values. It is also found that there is no model or mechanism for testing whether the law which under legislation has been appropriate and conformed with Pancasila. The current indicators and variables are the ones set by the Agency for National Law Development (BPHN) and the Agency for Pancasila Ideology Education (BPIP), and are used to evaluate a positive law. In fact, they are not the ones intended to to evaluate a law which is currently in the level of legislation. This article argues that in order to actualize Pancasila values in the established law, indicators and variables regarding Pancasila values need to be regulated in a law. Besides, it is encouraged that the evaluation and testing mechanisms be implemented during legislation process.
Abstrak
Dalam sistem hukum Indonesia, Pancasila merupakan sumber dari segala sumber hukum, dasar hukum nasional, dan cita hukum. Dengan kedudukan yang demikian itu, maka sudah seharusnya semua hukum yang dibentuk mencerminkan atau selaras dengan nilai-nilai Pancasila. Artikel ini bermaksud menelusuri bagaimana nilai-nilai Pancasila diaktualisasi dalam pembentukan suatu undang-undang. Dalam artikel ini ditunjukkan, sekalipun Pancasila memiliki peran yang sangat penting bagi suatu undang-undang yang dibentuk, ternyata belum ada indikator dan variabel tentang undang-undang yang mencerminkan atau selaras dengan nilai-nilai Pancasila. Artikel ini juga menunjukkan, belum ada model atau mekanisme pengujian apakah undang-undang yang sedang dalam tahap pembentukannya telah sesuai dan selaras dengan Pancasila. Indikator dan variabel yang ada sejauh ini ialah yang ditetapkan oleh Badan Pembinaan Hukum Nasional dan Badan Pembinaan Ideologi Pancasila, dan digunakan untuk mengevaluasi suatu undang-undang yang telah berlaku, bukan yang sedang dalam tahap pembentukannya. Karena itu, agar nilai-nilai Pancasila semakin teraktualisasi dalam undang-undang yang dibentuk, maka indikator dan variabel tentang nilai-nilai Pancasila perlu diatur dalam undang-undang, dan mekanisme evaluasi dan pengujiannya perlu didorong agar dapat dilakukan pula pada saat undang-undang sedang dalam tahap pembentukannya.
Jornal Hoje E Os Mediadores Da Tragédia De Suzano-Sp
Authors: Negrini Michele , Palermo Arildo 
Published: December 2020

Refletir sobre a análise de programas televisivos, principalmente se tratando dos noticiosos, requer a observação da complexidade que perpassa os processos que envolvem a produção audiovisual. A partir disso, achamos que os modos de endereçamento se mostram como uma perspectiva teórico-metodológica importante para análise de telejornais. Este artigo tem como foco principal analisar as primeiras notícias veiculadas a respeito da tragédia de Suzano-SP, no programa Jornal Hoje da Rede Globo, sob a ótica de um dos quatro operadores de análise propostos por Gomes (2007) dentro da teoria dos modos de endereçamento: os mediadores.
Palavras-chave: Modos de endereçamento; Jornal Hoje; telejornalismo; mediadores.
Characteristics of an Exemplary Living Collection
Authors: Gates Galen 
Published: December 2020

The purpose of this study was to analyse the characteristics that define a plant collection. In 2002 Chicago Botanic Garden benchmarked the living plant collections in national and international botanic gardens and arboreta in seven countries. The result of the study revealed that there were twelve characteristics of an exemplary living collection. These were:
I. Institutional Collections Policy and Development PlansII. High diversity (breadth in taxa and germplasm)III. Depth or areas of specialization (plant-related areas)IV. Thorough record-keepingV. Care – maintenance practicesVI. An active Verification ProgrammeVII. Plants of wild origin with cultivated plants from their introducerVIII. Taxa of conservation concernIX. Staff expertise (knowledge acquired from the building and study of the Collection)X. Public access (to view and study plants and benefit from associated Programming)XI. Plant Exploration ProgrammesXII. Relevance to science and society for multiple generations
Student Project A comparison of natural & synthetic rooting hormones for cuttings propagation using Saxagothea conspicua Lindl.
Authors: Cayon-Fernnadez Isabel 
Published: December 2020

This paper examines the effects of using natural and synthetic rooting hormones for cuttings propagation. The study used Saxegothaea conspicua Lindl, a Near Threatened conifer native to Chile and Argentina. A trial was set on 80 semi-ripe cuttings of S. conspicua applying both synthetic (IBA) and natural hormones derived from willow and lentils. This study evaluates and measures the rooting success of using different types of hormones at the end of the trial (such as development of roots, length, etc). It also aims to examine the level and type of auxins found in the lentil and willow rooting solution, if present. After evaluation of results of the present trial and the wider literature, this paper discusses the potential use of this type of natural hormones in future.
This article is an extract from the author’s HND Specialist Project written for the RBGE Diploma in Horticulture with Plantsmanship in June 2018.
A histologic surprise in case of an Ileocolic intussusception in adult - diffuse large B cell lymphoma colon
Authors: Chirukandath Ravindran , Babu Agil , Dev Ayana Manjookaran , Vijay Rajendran Manjookaran Gokul , Radhakrishnan Lakshmi , Sreedharan Sreelekha Padinjekara 
Published: December 2020

Background:
Intussusception in adults is distinct from pediatric intussusception in many aspects. In contrast to intussusceptions in children, a demonstrable etiology is found in 70%-95% of the cases in the adult population, and approximately 40% of them are caused by primary or secondary malignant neoplasms. But lymphomas, as a cause of lead point in adult intussusception, are extremely rare and only less than 50 cases have been reported in the literature.

Case Presentation:
We are reporting a 44-year-old male who presented with a right iliac fossa mass and clinical features of intussusception and who was operated upon. Per-operative findings were consistent with ileocecal intussusception and a radical right hemicolectomy was conducted. Histopathological examination revealed it as a case of Difuse Large B Cell Lymphoma presenting as the lead point. This case is discussed because of the rarity of the disease and possible cure if diagnosed early and treated aggressively.

Conclusion:
Ileocolic intussusception is adults is usually caused by malignancy and mostly as adenocarcinoma. Non-Hodgkin lymphoma as a lead point is extremely rare and is usually a histologic surprise. However, a radical en mass resection without reduction is ideal in all forms of adult colocolic and ileocolic intussusception.
The Effects of Furosemide usage on Organ System Failure Status based on Modified Sequential Organ Failure Assessment Score in Critically ill Patient
Authors: Marcevianto Kevin Varian , Aditianingsih Dita , Pramudita Eka , Aristya Lara 
Published: December 2020

Objectives:
Eighty-six percent of patients administrated with intravenous fluid resuscitation had positive fluid accumulation. This resulted in fluid overload in 35% of all ICU patients in 2009–2012. Then, the worst consequence is multi-organs failures. Thus, one of the treatments is pharmacological diuresis to solve physiological problems. Despite of its adverse effects and fluid balance decrement on the hypoperfused organ, the organ failure resolution of furosemide usage has not been proven through any research. Hence, a research which analyzed the correlation of organ system failure status based on modified sequential organ failure assessment (MSOFA) score with furosemide usage on intensive care patient and their demographics data has been conducted.

Material and Methods:
The research design was a retrospective cohort which analyzed 194 subjects through ICU medical records selected by consecutive sampling method. Data of furosemide usage and MSOFA score changes were recorded. Thereafter, Chi-square test was conducted to analyze the data. Moreover, characteristics of subjects were also recorded and analyzed in this study.

Results:
Based on the characteristics of subjects analysis, significant factors on furosemide usage (P < 0.05) included total fluid changes, total fluid after therapy, organ system dysfunctions before therapy (including the respiratory and central nervous system), organ system dysfunction after therapy (cardiovascular), and MSOFA score before therapy. Very significant factors (P < 0.001) include total fluid before therapy, organ system dysfunction after therapy (central nervous system), and MSOFA score after therapy. There was a significant association between worsening organ system failure with furosemide usage on critically ill patients, especially in the cardiovascular and central nervous system. The relative risk result reported that furosemide usage resulted in higher MSOFA score 1.271 times more than those patients with no furosemide diuresis usage (95% CI 1.108– 1.458). Furosemide usage in this research worsens organ dysfunction, especially in cardiovascular and central nervous systems.

Conclusion:
The furosemide usage worsens the organ failure based on MSOFA score. Furosemide therapy should be individually adjusted, especially in those who have respiration, cardiovascular, and central nervous system dysfunction.
The influence of calcium signaling on the development of autism spectrum disorders
Authors: Соловьева Н.В. , Чаусова С.В. , Кичук И.В. , Макарова Е.В. 
Published: December 2020

Расстройства аутистического спектра (РАС) являются сложной группой нейропсихиатрических заболеваний с точки зрения этиопатогенеза. В основе нейрональных нарушений, приводящих к аутистической симптоматике, лежат дисфункции сигнальных путей. Согласно последним исследованиям одним из наиболее значимых сигнальных путей в развитии данной группы заболеваний является кальциевый сигнальный путь. Кальциевая сигнализация тесно связана с такими сигнальными путями, как MAPK-, Wnt-, PI3K/AKT/mTOR-, нарушение в работе которых приводит к нарушениям серотонинергической, дофаминергической, опиоидной, холинергической, глутаматергической, ГАМКергической передачи и влечет за собой эксайтотоксичность за счёт гиперактивации NMDA- и AMPA-рецепторов, повреждение и гибель нейронов. Все эти процессы в нейрональных клетках напрямую связаны с формированием долговременного потенцирования и депрессии, а нарушения в этих клетках приводят к дисфункции базисных психических процессов. С клинической точки зрения кальциевый сигнальный путь может стать одной из основных мишеней для фармакологической коррекции симптоматических проявлений РАС. Очевидно, что дальнейшие исследования на животных моделях и электрофизиологические клинические исследования необходимы для понимания патогенетических особенностей развития РАС, а также какое именно место занимает сигнальный путь Ca 2+ в данных состояниях. Дальнейшие исследования необходимы, для прояснения потенциальной роли сигнализации Ca 2+в изменениях социального или стериотипического поведении пациентов, что является основной обенностью РАС.
Autism spectrum disorders (ASDs) are a group of neuropsychiatric diseases with a complex etiopathogenesis. Neuronal disorders leading to autistic symptoms are determined by dysfunction of signaling pathways. Recent studies have demonstrated that the calcium signaling pathway is one of the major significant pathways for this group of disorders. Calcium signaling is closely linked to MAPK-, Wnt-, and PI3K/AKT/mTOR -pathways, which abnormalities lead to dysfunction of serotonergic, dopaminergic, opioidergic, cholinergic, glutamatergic, and GABAergic transmission and result in excitotoxicity due to hyperactivation of NMDA and AMPA receptors and neuronal damage and death. These processes in neuronal cells are associated with formation of long-term potentiation and depression, and disturbances in these cells lead to failure of basic mental processes. From a clinical point of view, the calcium signaling pathway can become one of major targets for the pharmacological treatment of symptomatic ASD. Obviously, further animal studies and electrophysiological human studies are required for understanding pathogenetic mechanisms of ASD and the contribution of Ca 2+ signaling. Future research will clarify a potential role of Ca 2+ signaling in social or stereotypic behavior, which constitutes a main feature of ADS.
Analysis of the anticancer effect of endostatin on oral squamous cell carcinoma based on results of experimental studies
Authors: Тугузбаева Г.М. , Павлов В.Н. , Еникеев Д.А. 
Published: December 2020

При плоскоклеточном раке полости рта основной причиной летальных исходов является метастазирование в регионарные лимфатические узлы. Злокачественный рост и формирование метастазов напрямую зависят от степени кровоснабжения первичного очага новообразования. Известно, что по мере прогрессирования опухолевый процесс сопровождается нарушением сбалансированной в норме системы регуляции ангиогенеза с превалированием уровня ангиогенных стимуляторов над ингибиторами. В связи с этим, использование антиангиогенных средств является патофизиологически обоснованным методом борьбы со злокачественным ростом. В обзоре обсуждаются данные доклинических исследований участия эндостатина, природного ингибитора ангиогенеза, в процессах подавления прогрессии и метастазирования плоскоклеточного рака челюстно-лицевой области. Проанализированы патогенетические механизмы ингибирования эндостатином опухолевого роста в экспериментальных моделях рака полости рта. Эндостатин можно рассматривать в качестве потенциального противоопухолевого средства для лечения данной нозологии.
The main reason for cancer-associated mortality in patients with oral squamous cell carcinoma is metastatic spread to regional lymph nodes. It is known that the processes of malignant growth and metastasis are highly dependent on blood supply to the primary cancerous focus. The development of malignancy is accompanied by failure of the normally well-balanced system of angiogenesis regulation with prevalence of proangiogenic factors over inhibitors. Therefore, the use of angiogenic inhibitors is a pathophysiologically justified method aimed at suppression of cancer progression. This review presents reports of experimental studies on the role of endostatin, a natural inhibitor of angiogenesis, in processes of tumour shrinkage in squamous cell carcinoma of the maxillofacial region. The authors analysed pathogenic mechanisms of the anticancer effects exhibited by endostatin in preclinical models of oral malignancy. Endostatin can be regarded as a potential antitumor agent for the treatment of oral squamous cell carcinoma.
Evaluation of lockdown effect on SARS-CoV-2 dynamics through viral genome quantification in waste water, Greater Paris, France, 5 March to 23 April 2020
Authors: Wurtzer S , Marechal V , Mouchel JM , Maday Y , Teyssou R , Richard E , Almayrac JL , Moulin L 
Published: December 2020

Introduction
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of coronavirus disease (COVID-19). People infected with SARS-CoV-2 may exhibit no or mild non-specific symptoms; thus, they may contribute to silent circulation of the virus among humans. Since SARS-CoV-2 RNA can be detected in stool samples, monitoring SARS-CoV-2 RNA in waste water (WW) has been proposed as a complementary tool to investigate virus circulation in human populations.

Aim
To test if the quantification of SARS-CoV-2 genomes in WW correlates with the number of symptomatic or non-symptomatic carriers.

Method
We performed a time-course quantitative analysis of SARS-CoV-2 by RT-qPCR in raw WW samples collected from several major WW treatment plants in Greater Paris. The study period was 5 March to 23 April 2020, including the lockdown period in France (from 17 March).

Results
We showed that the increase of genome units in raw WW accurately followed the increase of human COVID-19 cases observed at the regional level. Of note, the viral genome could be detected before the epidemic grew massively (around 8 March). Equally importantly, a marked decrease in the quantities of genome units was observed concomitantly with the reduction in the number of new COVID-19 cases, 29 days following the lockdown.

Conclusion
This work suggests that a quantitative monitoring of SARS-CoV-2 genomes in WW could generate important additional information for improved monitoring of SARS-CoV-2 circulation at local or regional levels and emphasises the role of WW-based epidemiology.