bluuebunny/crossref_metadata_2025_split huggingface dataset:
Did I imagine that? The functional role of paracingulate cortex in reality monitoring
Authors: Garrison JR , Saviola F , Morgenroth E , Barker H , Lührs Michael , Simons JS , Fernyhough C , Allen P 
Published: May 2020

AbstractReality monitoring describes our ability to distinguish between internally and externally generated experiences. Individuals show significant variation in this ability and impaired reality monitoring has been linked to the experience of hallucinations. We undertook two studies to investigate the association between reality monitoring and morphology of the paracingulate region of medial prefrontal cortex. In Study 1 we compared reality monitoring accuracy and functional connectivity within paracingulate cortex in groups of healthy controls (N=20) and patients with schizophrenia and hallucinations (N=19). Controls showed greater reality monitoring accuracy that was associated with resting-state functional connectivity between paracingulate, precuneus and occipital cortices, while reality monitoring in patients was associated with more lateral functional connectivity. In Study 2 we used real-time fMRI neurofeedback to obtain causal evidence for the role of the paracingulate cortex in reality monitoring. Healthy individuals received Active feedback from paracingulate cortex (N=21) or Sham feedback based on randomised signal (N=18). Active-group participants showed a specific behavioural effect of improved reality monitoring for Imagined items, as well as increases in both activity within the paracingulate region, and its posterior functional connectivity with precuneus and lateral parietal cortices, and occipital cortex.Our findings suggest reality monitoring in healthy individuals is causally supported by a paracingulate mediated flexible network including the precuneus. Network connectivity can be enhanced using neurofeedback and tracks with improved reality monitoring ability. In contrast, patients with schizophrenia may utilise a distinct and more lateral network which may explain observed sub-optimal reality monitoring accuracy, contributing to the experience of hallucinations.Significance StatementReality monitoring refers to our ability to distinguish imagination from our experiences in the outside world, and is linked both to hallucinations in schizophrenia as well as to the morphology of paracingulate cortex area of the brain. Here, we revealed less paracingulate involvement in the functional reality monitoring networks in patients with schizophrenia compared to healthy individuals. Thereafter, we used real-time fMRI neurofeedback to show that healthy individuals can learn to upregulate brain activity within the paracingulate cortex, with this resulting in both improved reality monitoring ability and changes in paracingulate functional connectivity. This suggests that paracingulate cortex activity and connectivity play a causal role in reality monitoring, with implications for both the understanding and treatment of hallucinations.
Detecting radiographic sacroiliitis using deep learning with expert-level accuracy in axial spondyloarthritis
Authors: Bressem Keno K. , Vahldiek Janis L. , Adams Lisa C. , Niehues Stefan M. , Haibel Hildrun , Rodriguez Valeria Rios , Torgutalp Murat , Protopopov Mikhail , Proft Fabian , Rademacher Judith , Sieper Joachim , Rudwaleit Martin , Hamm Bernd , Makowski Marcus R. , Hermann Kay Geert A. , Poddubnyy Denis 
Published: May 2020

ABSTRACTConventional radiographs of sacroiliac joints from two independent cohorts of patients with axial spondyloarthritis (axSpA) were used to develop and validate an artificial neural network for the detection of definite radiographic sacroiliitis as a manifestation of the disease. The first cohort consisting of 1669 radiographs labelled by three experts was used for training. From the second cohort 100 radiographs labelled by two experts were randomly selected for the test dataset. The neural network achieved an excellent performance in detection of definite radiographic sacroiliitis with an area under the receiver operating characteristics curve of 0.97 and 0.96 for the validation and test datasets, respectively. Sensitivity and specificity for the cut-off weighting both measurements equally were 0.90 and 0.93 for the validation and 0.87 and 0.97 for the test set. The Cohen’s kappa between the neural network and the reference judgements were 0.80 for both validation and test sets, and the absolute agreement on the classification yielded 91% and 90%, respectively.
Rdh54/Tid1 Inhibits Rad51-Rad54-Mediated D-loop Formation and Limits D-loop Length
Authors: Shah Shanaya Shital , Hartono Stella , Piazza Aurèle , Som Vanessa , Wright William , Chédin Frédéric , Heyer Wolf-Dietrich 
Published: May 2020

ABSTRACTDisplacement loops (D-loops) are intermediates formed during homologous recombination that play a pivotal role in the fidelity of repair. Rdh54 (a.k.a. Tid1), a Rad54 paralog inSaccharomyces cerevisiae, is well-known for its role with Dmc1 recombinase during meiotic recombination. Yet contrary to Dmc1, Rdh54 is also present in somatic cells where its function is less understood. While Rdh54 enhances the Rad51 DNA strand invasion activityin vitro, it is unclear how it interplays with Rad54-mediated invasions. Here, we show that Rdh54 inhibits D-loop formation by Rad51 and Rad54 in an ATPase-independent manner. Using a novel D-loop Mapping Assay, we further demonstrate that Rdh54 uniquely restricts the lengths of Rad54-mediated D-loops. The alterations in D-loop properties appear to be important for cell survival and mating-type switch in haploid yeast, whereas Rdh54 expression is suppressed in diploids. We propose that Rdh54 and Rad54 compete for potential binding sites within the Rad51 filament, where Rdh54 acts as a physical roadblock to Rad54’s translocation activity, limiting D-loop formation and D-loop length.
Immunization with the receptor–binding domain of SARS-CoV-2 elicits antibodies cross-neutralizing SARS-CoV-2 and SARS-CoV without antibody-dependent enhancement
Authors: Zang Jinkai , Gu Chenjian , Zhou Bingjie , Zhang Chao , Yang Yong , Xu Shiqi , Zhang Xueyang , Zhou Yu , Bai Lulu , Wu Yang , Sun Zhiping , Zhang Rong , Deng Qiang , Yuan Zhenghong , Tang Hong , Qu Di , Lavillette Dimitri , Xie Youhua , Huang Zhong 
Published: May 2020

AbstractRecently emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic. Currently, there is no vaccine available for preventing SARS-CoV-2 infection. Like closely related severe acute respiratory syndrome coronavirus (SARS-CoV), SARS-CoV-2 also uses its receptor-binding domain (RBD) on the spike (S) protein to engage the host receptor, human angiotensin-converting enzyme 2 (ACE2), facilitating subsequent viral entry. Here we report the immunogenicity and vaccine potential of SARS-CoV-2 RBD (SARS2-RBD)-based recombinant proteins. Immunization with SARS2-RBD recombinant proteins potently induced a multi-functional antibody response in mice. The resulting antisera could efficiently block the interaction between SARS2-RBD and ACE2, inhibit S-mediated cell-cell fusion, and neutralize both SARS-CoV-2 pseudovirus entry and authentic SARS-CoV-2 infection. In addition, the anti-RBD sera also exhibited cross binding, ACE2-blockade, and neutralization effects towards SARS-CoV. More importantly, we found that the anti-RBD sera did not promote antibody-dependent enhancement of either SARS-CoV-2 pseudovirus entry or authentic virus infection of Fc receptor-bearing cells. These findings provide a solid foundation for developing RBD-based subunit vaccines for SARS-CoV2.
HetL provides immunity to HetR against PatS inhibition, and promotes pattern formation in the cyanobacteriumNostocPCC 7120
Authors: Xu Xiaomei , Risoul Véronique , Byrne Deborah , Champ Stéphanie , Douzi Badredinne , Latifi Amel 
Published: May 2020

AbstractLocal activation and long-range inhibition are mechanisms conserved in self-organizing systems leading to biological patterns. A number of them involve the production by the developing cell of an inhibitory morphogen, but how this cell gets immune to self-inhibition is rather unknown. Under combined nitrogen starvation, the multicellular cyanobacteriumNostocPCC 7120 develops nitrogen-fixing heterocysts with a pattern of a heterocyst every 10-12 vegetative cells. Cell differentiation is regulated by HetR which activates the synthesis of its own inhibitory morphogen (PatS), which diffusion establishes the differentiation pattern. Here we show that HetR interacts with HetL at the same interface as PatS, and that this interaction is required to suppress inhibition and to differentiate heterocysts.hetLexpression is induced under nitrogen-starvation and is activated by HetR, suggesting that HetL provides immunity to the heterocyst. This protective mechanism might be conserved in other differentiating cyanobacteria as HetL homologues are spread across the phylum.
COX-1 – lipid interactions: arachidonic acid, cholesterol, and phospholipid binding to the membrane binding domain of COX-1
Authors: Sejdiu Besian I. , Tieleman D. Peter 
Published: May 2020

AbstractCyclooxygenases carry out the committed step in prostaglandin synthesis and are the target of NSAIDs, the most widely used class of drugs in alleviating pain, fever, and inflammation. While extensively studied, one aspect of their biology that has been neglected is their interaction with membrane lipids. Such lipid-protein interactions have been shown to be a driving force behind membrane protein function and activity. Cyclooxygenases (COX-1 and COX-2) are bound on the luminal side of the endoplasmic reticulum membrane. The entrance to their active site is formed by a long hydrophobic channel which is used by the cyclooxygenase natural substrate, arachidonic acid, to access the enzyme. Using atomistic and coarse-grained simulations, we show that several membrane lipids are capable of accessing the same hydrophobic channel. We observe the preferential binding of arachidonic acid, cholesterol and glycerophospholipids with residues lining the cavity of the channel. We find that the membrane binding domain (MBD) of COX-1 is usually in a lipid-bound state and not empty. This orthosteric binding by other lipids suggests a potential regulatory role of membrane lipids with the possibility of affecting the COX-1 turnover rate. We also observed the unbiased binding of arachidonic acid to the MBD of COX-1 allowing us to clearly delineate its binding pathway. We identified a series of arginine residues as being responsible for guiding arachidonic acid towards the binding site. Finally, we were also able to identify the mechanism by which COX-1 induces a positive curvature on the membrane environment.
Drying technology of mesquite pods (Prosopis laevigata) and microstructural insights
Authors: Sandoval Torres Sadoth , Lopez Cravioto Daniel , Rodríguez Ramírez Juan , Méndez Lagunas Lilia L. , Barriada Bernal Luis Gerardo , González Laura V. Aquino 
Published: May 2020

PurposeMesquite pods offer a high nutritional content; A flour can be produced from them; nevertheless, the moisture content makes the milling process difficult. Then, before the milling operation a drying process must be implemented, but drying technology must be studied in order to characterise the process and identify the effect of drying temperature on the magnitude of drying rate.Design/methodology/approachProsopis Laevigata pods were collected in Oaxaca (Southern of Mexico) and they were dried. Three stages of maturity were identified and pods in the stage three of maturity were dried by forced convection. The internal structure of the pods was analyzed by scanning electron microscopy (SEM). The pods were dried in a tunnel dryer at 40, 50, 60 and 70° C, 10% relative humidity and air velocity of 2.6 m/s. From experimental data, a lumped analysis was conducted for drying.FindingsWe found that the internal microstructure of this material is a limiting factor for moisture migration. In order to reduce the moisture content in the pods, a minimum air temperature of 60° C must be applied. The characteristic drying curve shows a good agreement with the experimental drying kinetics. The nutritional composition (carbohydrates, sugar and protein) of pods reveals important applications for the food industry.Practical implicationsThe mesquite pods are important ethnic foods. In order to obtain flour, the drying of pods is mandatory. Drying must be applied in stage three of maturity which can be identified based on color changes and moisture content. The moisture content affects the performance of milling operation, then a minimum drying temperature of 60° C and low relative humidity must be applied. SEM images show the complex microstructure of the pods which hinders the moisture diffusion. The drying characteristic curve was deduced for the first time; it helps to understand the drying behavior of pods. The chemical composition of mesquite pods reveals interesting applications for the food industry. The methodology for drying is useful for researchers and producers.Originality/valueMezquite pods is an interesting ethnic food for people with celiac disease. This is the first time a research paper describes the drying process at detail. The SEM images, the convective drying operation and the characteristic curve are presented for the first time. The information will be useful for the industry and academia.
Joiner & Sons Hardware: Exploring Multichannel Opportunities to Prepare for Developing an Omnichannel Strategy
Authors: Farris Theodore 
Published: May 2020

The premise of the case is how to make best use of customer shopping time while staying competitive and profitable: The increase in the number of ecommerce-based channels and the growth of Amazon and Wal*Mart have forced brick-and-mortar retailers to seek alternative ways to reach potential customers in a cost- and time-efficient manner. In the U.S., an average of 0.74 hours per day is spent purchasing goods and services, while an average of 1.77 hours per day is spent doing household activities. Regardless of location, customers all have the same 24 hours in a day and only so much of it can be spent shopping.One of the benefits of ecommerce has been an increase in product variety offered to customers. The online marketplace has enabled consumers in many industries to locate, evaluate and purchase a far wider variety of products than they can with traditional brick-and mortar channels. 30% to 40% of Amazon book sales are titles that wouldn't normally be found in brick-and-mortar stores.
Enjoying or refraining from risk? The impact of implicit need for achievement and risk perception on SME internationalization
Authors: Handrito Radityo Putro , Slabbinck Hendrik , Vanderstraeten Johanna 
Published: May 2020

PurposeThis study aims to explore how an entrepreneur's implicit need for achievement and risk reception contribute to internationalization performance.Design/methodology/approachThis study involves 176 Indonesian entrepreneurs. The authors use the Operant Motive Test to assess the entrepreneur's implicit needs and apply hierarchical Tobit regression to assess the interplay between implicit need for achievement, risk perception and internationalization.FindingsThe authors show that an entrepreneur's basic needs and risk perception play an essential role in SME internationalization. More specifically, the authors reveal a positive association between the entrepreneur's need for achievement and small and medium enterprises (SME) internationalization. They also show a U-shaped relationship for the moderation effect of risk perception on this relationship. That is, for a high need for achievement-motivated entrepreneur, the level of internationalization is at the highest when risk perception is either very low or very high.Originality/valueIn this study, the authors argue that analyses at the entrepreneur's individual level are indispensable to better understand firm internationalization. The authors argue that the role of psycho-cognitive characteristics of individuals (such as motivational dispositions) received too little attention, compared to factors at the firm or environmental level. This study examines such personality aspects and finds that implicit need for achievement and risk perception impact SME internationalization.
Financing Russian firms: Ireland and round tripping
Authors: Doyle Cillian , Stewart Jim 
Published: May 2020

Purpose
Ireland has become one of the main sources of finance for Russian based firms. The purpose of this paper is to quantify and analyse these flows to examine governance and regulatory issues, in particular the possible effect of sanctions.

Design/methodology/approach
The paper is based on detailed searches of publicly available filings in Company House, Ireland to identify Russian connected conduits. Data was extracted from available accounts and prospectuses for 106 conduits operating in Ireland for some or all of the period 2005-2017.

Findings
The paper shows gross flows from Irish based conduits to Russian firms amounted to €118bn for 2005-2017; flows may be partly explained by round tripping; sanctions have also affected flows; flows are facilitated by close linkages with professional networks both within Ireland, and other offshore financial centres, especially London; The conduits examined have no employees and are mostly owned by a charitable trust or trust. They have become a major part of a largely unregulated shadow banking system.

Originality/value
This paper used searches of publicly available company filings to create a unique database of individual firms. Data on the use of financial centres by individual firms is hard to obtain and the results of this study may be indicative of the use and nature of conduits in other financial centres which form part of the shadow banking sector.
A cyclic symmetric model for the investigation of vibration reduction of hard-coating blisk
Authors: Sun Wei , Yang Shuai , Gao Junnan , Yan Xianfei 
Published: May 2020

Purpose
It is very important to create a useful cyclic symmetric model for the investigation of the vibration reduction effect of hard-coating blisk. This study aims to develop a cyclic symmetry algorithm which can determine the mode of blisk in the sector coordinate system directly.

Design/methodology/approach
Using the exponential and real quasi-equivalent Fourier matrices, the formulas for solving the sector mode were derived, and the relationship between the two kinds of sector modes was also discussed. Based on the proposed cyclic symmetry algorithm, the vibration characteristics of an academic blisk were solved, and the formulas for solving the natural characteristics and vibration responses of the coated blisk were given.

Findings
A blisk with NiCrAlCoY+YSZ hard coating on both sides of each blade was chosen as a case to demonstrate the presented method. Based on the verification analysis model, the influences of coating thickness on the vibration reduction effect of the blisk were discussed. The results show that the hard coating has good vibration reduction effect on the blisk even the coating thickness is very thin and the vibration reduction effect of hard coating in the high frequency range is obviously better than that in the low frequency range.

Originality/value
As a large number of reduced order modeling methods of blisk are implemented based on the sector modes, the proposed method which can obtain the sector modes directly will significantly improve the efficiency of dynamic modeling and analysis of the coated blisk structure.
When friends become enemies: co-opetition relationships between banks and third-party payment providers
Authors: Zhang Xueli , Yang Defeng 
Published: May 2020

PurposeThe purpose of this paper is to investigate the conditions under which working with an incumbent downstream competitor could be a beneficial strategy for upstream firms as the case of the relationship between banks and third-party payment providers.Design/methodology/approachUsing a game model, this study considers a market with two upstream firms (banks) and two downstream firms (third-party payment providers). One downstream firm is an incumbent that poses a competitive threat to the upstream market, and the other downstream firm does not.FindingsThe results show that the optimal decision for banks depends on the number of loyal users the incumbent third-party payment providers and banks have. When the bank has more loyal users than the competitive third-party provider to a certain level, it would terminate cooperation with the provider; otherwise, the bank would maintain cooperation. This is true whether the duopoly banks are symmetrical or asymmetrical.Originality/valueThis study makes contribution to the theory of co-opetition lies in the fact that it examines a special case of competition and cooperation between vertical enterprises in the bank context. This study investigates how the upstream firms do when threatened by a downstream firm while the upstream firms have other options. This study also contributes to bank marketing theory through providing explanations for some of the incomprehensible cooperation in China's payment market, which is characterized by consumer loyalty. This study extends previous new-entry competition for banks by differentiating between incumbent and new-entry downstream firms.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJBM-11-2019-0414
Efficient team formation from pool of talent: comparing AHP-LP and TOPSIS-LP approach
Authors: Dwivedi Preeti , Chaturvedi Vijit , Vashist Jugal Kishore 
Published: May 2020

PurposeThis research focuses on suggesting an optimized model for selecting best employees using advanced multi-criteria decision making method to a supply chain firm, who is planning to start a new cold chain business vertical.Design/methodology/approachStudy has been conducted in a supply chain firm in North India, who wants to expand its business with the help of efficient team members. In total 38 applicants were considered for the study, as selected by the firm after initial screening from pool of talent. AHP-LP and TOPSIS-LP integrated approach were applied separately for evaluation and implementation of personnel selection model. Further, both the approaches were compared to find the best fit and optimized model.FindingsAs per the findings, both AHP and TOPSIS can be used to select the best candidate among the alternatives available. TOPSIS was found easier to implement as it involves ranking of applicants with respect to each skills required for respective job profile only once, whereas AHP involves pair-wise comparison among candidates with respect to each skills required for respective job profile and normalization of each comparison, resulting in the formation of number of comparison matrices. However, AHP is more reliable as it considers consistency check for each level of pair-wise comparison. Hence, there is a chance to avoid or revise the human judgment error. Integrated ranking and optimization approach minimizes the cost by suggesting the relevant positions to be filed to make an efficient team.Research limitations/implicationsGroup of interviewers are involved in the decision-making process, hence there are chances of biasness in ranking method which can influence the group decision. Research is limited to a particular geography of North India therefore needs to be tested for other regions also in order to generalize. The research will help the third party logistics (3PL) and other related firms in efficient team selection.Originality/valueThe researcher focuses on formalizing a method for potential candidate selection by considering the constraints of the organization. It has been observed that limited researches have been done on the application of AHP-LP or TOPSIS-LP integrated approach for selection process. Hence, this research proposes two integrated ranking-optimization method and suggests the best fit by comparing both the approaches.