bluuebunny/crossref_metadata_2025_split huggingface dataset:
Persistencia de anticuerpos IgG contra SARS-CoV2 en personal de salud - provincia de Buenos Aires.
Authors: Pifano Marina , Fischerman Laura , Ercole Regina , Muñoz Laura , Kreplak Nicolas , Garcia Enio , Comes Yamila , Bologna Rosa 
Published: December 2020

Objetivo: evaluar la persistencia de los anticuerpos IgG contra SARS-CoV2, en trabajadores de salud del subsector público de la Provincia de Buenos Aires, y correlacionarla con variables demográficas (sexo, edad) y otros indicadores de salud (diagnóstico de COVID-19, comorbilidades y embarazo).
Metodología: Estudio descriptivo, observacional, de corte transversal. Al personal de salud con un resultado positivo en una primera muestra (N=388) se les realizó una segunda prueba para evaluar la persistencia de anticuerpos mediante ELISA.
Resultados: De las 386 personas evaluadas con resultado concluyente, 296 contaban con un primer resultado positivo entre los 30 y los 90 días anteriores a la segunda prueba, el 90% presentó anticuerpos detectables. En aquellas personas con un resultado positivo hacía más de 90 días (45) se observó una caída significativa en la persistencia del 26,7%. No hubo asociaciones significativas entre las variables demográficas y de salud y el resultado de la segunda prueba.
Conclusión: Los anticuerpos se mantienen detectables por al menos 90 días en el 90% de los casos analizados. Resulta fundamental continuar este estudio en el tiempo para contar con un período de tiempo mayor entre pruebas. La información aquí mostrada arroja datos interesantes y prometedores en cuanto a la posible protección de nuevos contagios de COVID-19 en personal con alta exposición de riesgo. Estas evidencias podrían contribuir a la toma de decisiones, tanto a nivel local como regional, para la adecuada planificación de la vacunación, así como también, para el manejo de la pandemia ante una posible segunda ola de casos en América Latina.
TrkC Is Essential for Nephron Function and Trans-Activates Igf1R Signaling
Authors: Lepa Carolin , Hoppe Sascha , Stöber Antje , Skryabin Boris V. , Sievers Laura Katharina , Heitplatz Barbara , Ciarimboli Giuliano , Neugebauer Ute , Lindenmeyer Maja T. , Cohen Clemens D. , Drexler Hannes C.A. , Boor Peter , Weide Thomas , Pavenstädt Hermann , George Britta 
Published: December 2020

Background
Injury to kidney podocytes often results in chronic glomerular disease and consecutive nephron malfunction. For most glomerular diseases, targeted therapies are lacking. Thus, it is important to identify novel signaling pathways contributing to glomerular disease. Neurotrophic tyrosine kinase receptor 3 (TrkC) is expressed in podocytes and the protein transmits signals to the podocyte actin cytoskeleton.

Methods
Nephron-specific TrkC knockout (TrkC-KO) and nephron-specific TrkC-overexpressing (TrkC-OE) mice were generated to dissect the role of TrkC in nephron development and maintenance.

Results
Both TrkC-KO and TrkC-OE mice exhibited enlarged glomeruli, mesangial proliferation, basement membrane thickening, albuminuria, podocyte loss, and aspects of FSGS during aging. Igf1 receptor (Igf1R)–associated gene expression was dysregulated in TrkC-KO mouse glomeruli. Phosphoproteins associated with insulin, erb-b2 receptor tyrosine kinase (Erbb), and Toll-like receptor signaling were enriched in lysates of podocytes treated with the TrkC ligand neurotrophin-3 (Nt-3). Activation of TrkC by Nt-3 resulted in phosphorylation of the Igf1R on activating tyrosine residues in podocytes. Igf1R phosphorylation was increased in TrkC-OE mouse kidneys while it was decreased in TrkC-KO kidneys. Furthermore, TrkC expression was elevated in glomerular tissue of patients with diabetic kidney disease compared with control glomerular tissue.

Conclusions
Our results show that TrkC is essential for maintaining glomerular integrity. Furthermore, TrkC modulates Igf-related signaling in podocytes.
Acoustic Emission Waveform Picking with Time Delay Neural Networks during Rock Deformation Laboratory Experiments
Authors: King Thomas , Benson Philip , De Siena Luca , Vinciguerra Sergio 
Published: December 2020

Abstract
We report a new method using a time delay neural network to transform acoustic emission (AE) waveforms into a time series of instantaneous frequency content and permutation entropy. This permits periods of noise to be distinguished from signals. The model is trained in sequential batches, using an automated process that steadily improves signal recognition as new data are added. The model was validated using AE data from rock deformation experiments, using Darley Dale sandstone in fully drained conditions at a confining pressure of 20 MPa (approximately 800 m simulated depth). The model is initially trained by manual picking of five high-amplitude waveforms randomly selected from the dataset (experiment). This is followed by semisupervised training on a subset of 300 waveforms.
Geologic Setting, Ground Effects, and Proposed Structural Model for the 18 March 2020 Mw 5.7 Magna, Utah, Earthquake
Authors: Kleber Emily J. , McKean Adam P. , Hiscock Adam I. , Hylland Michael D. , Hardwick Christian L. , McDonald Greg N. , Anderson Zachary W. , Bowman Steve D. , Willis Grant C. , Erickson Ben A. 
Published: December 2020

AbstractThe 18 March 2020 Mw 5.7 Magna, Utah, earthquake was the largest earthquake in Utah since the 1992 ML 5.8 St. George earthquake. The geologic setting of the Magna earthquake is well documented by recent geologic mapping at 1:24,000 scale and 1:62,500 scale at and near the epicenter northeast of Magna, Utah. Subsurface fault modeling from surficial geologic mapping, structural cross sections, deep borehole data, and geophysical data reveals a complex system of faulting concentrated in the hanging wall of the Weber and Salt Lake City segments of the Wasatch fault zone including the Harkers fault, the West Valley fault zone, and the newly interpreted Saltair graben. Based on geologic and geophysical data (seismic and gravity), we interpret the mainshock of the Magna earthquake as having occurred on a relatively gently dipping part of the Salt Lake City segment, with aftershocks concentrated in the Saltair graben and West Valley fault zone. Postearthquake rapid reconnaissance of geological effects of the Magna earthquake documented liquefaction near the earthquake epicenter, along the Jordan River, and along the Great Salt Lake shoreline. Subaerial and subaqueous sand boils were identified in regions with roadway infrastructure and artificial fill, whereas collapse features were noted along the shores of the Great Salt Lake. Potential syneresis cracking and pooling in large areas indicated fluctuating groundwater likely related to earthquake ground shaking. The moderate magnitude of the Magna earthquake and minimal geological effects highlight the critical importance of earthquake research from multidisciplinary fields in the geosciences and preparedness on the Wasatch Front.
NBN Futures Forum: Towards a National Broadband Strategy for Australia, 2020-2030
Authors: Campbell Leith H 
Published: December 2020

On 24 November 2020, TelSoc hosted the fifth NBN Futures Forum, held online, to launch the first major report, Towards a National Broadband Strategy for Australia, from the NBN Futures Group. The report, which summarized nearly two years of deliberations by the NBN Futures Group, contained 13 conclusions that were presented and discussed at the Forum. These conclusions supported the view that broadband is an essential service for Australia’s digital economy and society and that Australia’s National Broadband Network (NBN) is central to broadband provision. They promoted the concept of an overarching National Broadband Strategy to achieve social, economic and governmental goals. In addition to the main speech presenting the report’s conclusions, there were written statements from the Minister and Shadow Minister, supplementary remarks from two members of the NBN Futures Group, commentary from three panellists on consumer, policy and governmental perspectives, and general discussion. This paper summarizes the full content of the Forum.
László Tengelyi’s Phenomenological Metaphysics of the World
Authors: Patkul Аndrei 
Published: December 2020

In my paper, I reconstruct the basic features of the metaphysical conception of the world in László Tengelyi. I outline that he understands the world and its existence as a fact. In opposition to traditional ontology, Tengelyi believes that the fact of the world is of necessary. However, its necessity is not of logical a priori nature but conditioned by the concordance of experience. One ought to point out that the Tengelyi’s phenomenological metaphysics of the world is limited by the realm of experience. Following Husserl, he treats the world as the universal horizon of the experience. This is the horizon in which a thing can appear as limitless system of gradations. I analyze also the Tengelyi’s concept ‘project of world’ and explore two ‘projects’ of such a kind pointed in his metaphysics, namely (1) metontological transcendentalism and (2) naturalistic autarchism. I pay a special attention to the Tengelyi’s concept of the infinitude as a basic characteristic of the world. He considers it as the openness to the generation of the absolute new qualities of the things in the world.
Personalistic Concept of Moral Formation
Authors: Goliszek Piotr 
Published: December 2020

Personalistyczna koncepcja formacji moralnej
Formacja moralna o charakterze personalistycznym jest uniwersalna, ponieważ odwołuje się do prawdy o człowieku jako osobie. W pierwszej kolejności prowadzi do wartości chrześcijańskich, ale zasadniczo odnosi się do czegoś podstawowego – do wyposażenia właściwego każdej osobie ludzkiej: wierzącej czy niewierzącej. Dlatego w podstawach personalistycznej formacji moralnej bardzo ważne miejsce zajmuje koncepcja osoby. Od niej zależą poszczególne rozstrzygnięcia procesu formacji moralnej. Formacja moralna jawi się zatem jako najbardziej prozopoiczny sposób przekazywania wartości, czyli kształtowanie człowieka wysokiej miary. Szczególną rolę pełni tu osoba, która jest modelem poznawczym, metodą konstruowania wiedzy, a przede wszystkim miejscem i sposobem zespolenia osoby człowieka z Osobą Chrystusa. Personalizm koreluje z całą naturą moralności. Jest metodą, która zbliża prawdy wiary i moralności do egzystencji konkretnego człowieka; sprawia, że stają się bliskie dla jego umysłu i serca oraz odpowiadają na najgłębsze potrzeby jego życia. Ponadto formacja moralna o charakterze personalistycznym nie ograniczy się do sposobów przekazywania treści wiary i moralności, lecz będzie poszukiwać dróg samorozumienia, samointerpretacji i samowychowania wychowanków oraz sposobów rozumienia świata doczesnego, dziejów, życia, społeczności, kultury – w świetle Osoby Chrystusa.
Non Communicable Disease Programme of Colombo District, Sri Lanka: A Technical Report
Authors: J.L.H.R Wijegunasakara 
Published: December 2020

Non Communicable Diseases (NCD) are the dominant chronic health problem in Sri Lanka. NCDs are basically classified into 2 types; acute NCD & chronic NCD. Policies, Strategies, Activities and monitoring and evaluation plans are in place in the National NCD programme.
The objective of this case study is to study the Non Communicable Disease Programme of the division of Regional Director of Health Services (RDHS) – Colombo. Key informant’s interviews, review of secondary literature and observation in district review meetings were used to collect information.
It was found that RDHS division - Colombo is responsible for both preventive and curative heath care for a population of 2.2 Million through 56 health care institutions. With regard to NCDs; injury surveillance, advocacy, capacity building, development of information, education & communication material, social media strategies and regular reviews are in good progress while gaps were seen in pre admission care, coverage of service, utilization pattern, treatment of NCDs, health promotion, inter sectorial corporation and information management system.
Nominal group technique was used for prioritization. The issue of “NCD curative care provision is not optimum” was selected as the highest priority problem. Fish born diagram was developed to find root causes. The arm of “Physician factors” was selected to give recommendations and action plan was prepared accordingly.
Intervención del Tribunal de Justicia de la Unión Europea en el ámbito de coordinación de los sistemas de Seguridad Social europeos
Authors: Martínez Martínez Verónica Lidia 
Published: December 2020

Partiendo de una sucinta exposición de los antecedentes, integración y atribuciones del Tribunal de Justicia de la Unión Europea, con base en el método analítico y la consulta de los principales fallos pronunciados por este órgano jurisdiccional, en este trabajo son expuestas las principales temáticas de la jurisprudencia del Tribunal de Luxemburgo en el ámbito de la coordinación de los sistemas de Seguridad Social europeos.
Recibido: 30.06.2020Aceptado: 21.12.2020
El marco jurídico de los datos relativos a la salud en el ámbito de la salud y de la investigación en salud tras la entrada en vigor del Reglamento General de Protección de Datos y de la Ley de Protección de Datos Personales y garantía de los derechos
Authors: Serrano Pérez Mª Mercedes 
Published: December 2020

El tratamiento de los datos relativos a la salud tiene relevancia no solo a nivel individual en el entorno de la asistencia sanitaria personal, sino también desde el punto de vista colectivo, valorando la salud como un bien social. En la vertiente de la salud como bien comunitario, el empleo de los datos en investigación ha de rodearse de las garantías adecuadas para proteger los derechos de los sujetos, pero con la flexibilidad y racionalidad necesarias para no obstaculizar la labor de investigación en salud pública, que incluye también la investigación epidemiológica.
Recibido: 22.09.2020Aceptado: 21.12.2020
Gestación por sustitución: la dignidad humana en juego
Authors: Arroyo Gil Antonio 
Published: December 2020

La gestación por sustitución ha planteado serios problemas de orden público en aquellos Estados en los que, como es el caso de España, esta práctica no se encuentra legalizada. La tensión existente entre la dignidad y los derechos de la mujer gestante, los deseos de los futuros padres comitentes y, sobre todo, el interés superior del menor no pueden resolverse de manera automática, atribuyendo, en todo caso, prioridad a este último. Antes bien, se requiere un análisis pormenorizado de cada caso en el que se tengan en cuenta todas las circunstancias concurrentes. Las respuestas a nivel estatal son difíciles e insatisfactorias. Idealmente, sería precisa una solución de Derecho internacional público.
Recibido: 04.12.2020Aceptado: 21.12.2020
Islam and Tolerance: The Educational Pattern of Community in Kutuk Village, Kudus
Authors: Yusrina Jihan Avie , Ma'arif Syamsul 
Published: December 2020

This article expects the readers to witness the condition of religious harmony in the village of Kutuk in Undaan, Kudus, Central Java. The people who live in the village share various religious backgrounds, but they live side by side in harmony. This condition is achieved as the results of the education carried out by the Kutuk people since ancient times that has passed down through generations. Then, what kind of education pattern is being developed by the community to accompany every Muslim to be a tolerant ﬁgure? This research question is answered through a qualitative research with a case study approach that uses non-measurement techniques in data collection processes, namely observation, interviews, and documentation. This study conﬁrms that Kutuk village is a miniature of tolerant village in Kudus district. This village has a lifelong pattern of tolerance education, children with the education in their families, youth with peer education in youth organizations and adults with their educational councils. The methods that were utilized in the process of transmitting the tolerance values are education bil hal (education with good behavior and good examples), education bil maqol (education via oral tradition), and education bil du'a (education with a prayer). These ﬁndings provide some options to the community about applicable steps to empower families and communities in assisting Muslims to be tolerant. It is the evidence in the village that amaliyah of nahdliyyin such as yasinan, tahlilan, and berjanjenan have contributed signiﬁ cantly to educate Muslim to be socially and theologically pious adherents of Islam.
1900 METRE RAKIMDA HEMOGLOBİN YÜKSEKLİĞİ NEDENİ İLE BAŞVURAN OLGULARIN ETYOLOJİSİ: TEK MERKEZ DENEYİMİ
Authors: SİNCAN Gülden , SİNCAN Suat , TOPDAĞI Ömer , YÜKSEL Beyza , ERDEM Fuat , YILDIRIM Rahşan 
Published: December 2020

AMAÇ: Hemoglobin yüksekliğinin nedenleri primer, sekonder ve idiopatik olup; en önemli sekonder nedenlerden birisi yüksek rakımdır. Biz bu çalışmada 1900 metre rakımda olan Erzurum ilinde, hematoloji polikliniğine hemoglobin yüksekliği nedeniyle başvuran hastaların etyolojik nedenlerinin araştırılmasını amaçladık.
GEREÇ VE YÖNTEM: Çalışmamıza 180 hasta dahil edildi. Dünya Sağlık Örgütü’nün yayınladığı polisitemia vera tanı kriterlerine uygun olarak; hemoglobin değeri kadınlarda >16 g/dl, erkeklerde >16.5 g/dl ise yüksek olarak kabul edildi. Hastaların dosyaları retrospektif olarak incelendi ve yaş, cinsiyet, hemogram parametreleri, eritropoetin değeri, dalak boyutu, JAK2 mutasyon varlığı, kemik iliği biyopsi sonuçları, komorbid hastalıkları ve sigara alışkanlığı kaydedildi.
BULGULAR: Olguların yaş ortalaması 50.35±15.97 olup 50 (%27.8) olgu kadın, 130 (%72.2) olgu erkek idi. Olguların 176’sın da (% 97.8) mutlak, 4’ün de (% 2.2) rölatif hemoglobin yüksekliği saptandı. Hemoglobin değerinin üst sınırı rakıma göre düzeltildiğinde 12 (% 6.7) kadın, 16 (% 8.9) erkek olgunun hemoglobin değeri normaldi. Olguların 17’sin de (% 9.4) polisitemia vera, 152’sin de (%84.4) sekonder polisitemi saptanırken; 7 (% 3.9) olgu idiopatik olarak değerlendirildi. 15 (% 8.3) olguda JAK2V617F, 1 (% 0.6) olguda ekson 12 pozitif idi.
SONUÇ: Yüksek rakımda bulunan yerleşim yerlerinde, hemoglobin değerinin rakıma göre düzeltilerek ileri tetkike karar verilmesi, gereksiz tetkik yapılmasını engelleyip maliyeti azaltabilir.
Adherence to Clinical Quidelines on Preoperative Assessment and Correction of Cardiovascular Risk in Non-cardiac Surgery
Authors: Nigmatkulova M. D. , Kleymenova E. B. , Yashina L. P. , Otdelenov V. A. , Payushchik S. A. , Konova O. D. , Sychev D. A. 
Published: December 2020

Surgical care is associated with a high risk of complications. In 2014 the updated joint ESC/ESA guidelines on preoperative assessment and perioperative management of patients were published to improve patient safety in non-cardiac surgery. The increase in the adherence to clinical guidelines promotes the improving of the healthcare quality and safety improvement.Aim. To study physicians' level of adherence to ESC/ESA clinical guidelines for preoperative assessment and perioperative management of patients.Material and methods. A retrospective observational study included 102 patients admitted to Moscow general hospital from 01.03.2019 to 30.06.2018 for elective surgery. All of them underwent preoperative examination in outpatient department of the hospital and had at least one concomitant disease requiring drug therapy. The medical records data on the preoperative examination and perioperative treatment with beta-blockers, HMG CoA reductase inhibitors and angiotensin-converting-enzyme (ACE) inhibitors/ angiotensin receptor blockers (ARBs) were analyzed for compliance with the ESC/ESA guidelines.Results. A standardized cardiac risks assessment was not documented in the results of preoperative examination. Electrocardiography (ECG), echocardiography and non-invasive stress tests were performed according to clinical guidelines in 100%, 77.8% and 25% of cases, respectively. Unnecessary ECG and echocardiography were prescribed in 50.5% and 72% of cases, respectively. Appropriate correction of ACE inhibitors/ARBs therapy was performed in 66.7% patients with congestive heart failure and only in 2.7% with arterial hypertension. In 19 patients with ischemic cardiac disease, 13 (84.2%) patients received HMG CoA reductase inhibitors and 16 (68.4%) ones received beta-blockers during hospitalization. Inappropriate omission of statins, beta-blockers and ACE inhibitors (ARBs) during hospitalization was registered in 22.2%, 11% and 4.9% patients, respectively.Conclusion. The number of inappropriate ECGs and echocardiographies, as well as incorrect treatment with beta-blockers, HMG CoA reductase inhibitors and ACE inhibitors (ARBs) in perioperative period evidence that the adherence of physicians to the clinical guidelines on preoperative assessment and perioperative management of patients remains low.It is reasonably to develop risk-based interdisciplinary protocols for preoperative examination, algorithms for interdisciplinary communication and interaction between specialists and the healthcare levels, as well as physicians' education for better adherence to clinical guidelines.
AHMAD ZIYAUDDIN GUMUSHANEVI DAN TRADISI STUDI HADIS DI TEKKE ABAD KE-19 TURKI
Authors: Munji Ahmad 
Published: December 2020

<p>Sebagai sebuah disiplin ilmu dalam Islam tasawuf seharusnya berkiblat pada dua sumber utama, yaitu al-Qur’an dan hadis. Tradisi ini pada dasarnya telah berlangsung lama sejak lahirnya tasawuf. Hal ini ditandai dengan munculnya ulama-ulama dalam tasawuf yang merupakan periwayat hadis. Namun pada perjalanannya, ulama tasawuf banyak sekali mengabaikan faktor kesahihan sebuah hadis yang mereka jadikan sebagai bahan dakwah dan pedoman ibadahnya. Makalah ini bertujuan untuk menguak sebuah tradisi yang menarik antara tasawuf dan hadis di masa akhir kekaisaran Ottoman. Untuk membatasi periode supaya tidak melebar, pembahasan hanya akan berfokus pada abad 19 dan pada satu tokoh, Ahmad Ziyauddin Gumushanevi. Dengan menggunakan pendekatan historis dan metode deskriptif analitis, hasil kajian menyimpulkan bahwa Gumushanevi merupakan ulama tasawuf yang punya konsen terhadap kajian hadis. Hal ini dibuktikan dengan aktifitasnya dalam menulis karya seperti kumpulan hadis, <em>syarah</em>, dan kumpulan hadis <em>arba’in</em> yang menjadi trend ulama sebelumnya. Selain itu, Gumushanevi juga mempunyai kontribusi yang sangat besar terhadap keberlangsungan studi hadis di tengah masyarakat Ottoman melalui karya dan murid-muridnya.</p><p> </p><p>[<strong>Ahmad Ziyauddin Gumushanevi and the Tradition of Hadith Study in <em>Tekke</em> <strong>19<sup>th</sup></strong> Century Turkey</strong>.<strong> </strong>As an Islamic science discipline, Sufism must be oriented towards two main sources, the Qur'an and hadith. In fact, this tradition has been going on for a long time since the birth of Sufism. This is correlated with the scales of the scholars in Sufism who are the narrators of hadith. However, on their journey, Sufism scholars neglect the validity of a hadith which they use as material for their new preaching and worship. This paper aims to uncover an interesting tradition between Sufism and hadith at the end of the Ottoman Empire. In order to cope with the non-widened period, the discussion will only focus on the 19<sup>th</sup> century and on one character, Ahmad Ziyauddin Gumushanevi. By using a historical approach and analytical descriptive method, the results of the study conclude that Gumushanevi is a Sufism scholar who has a concern about hadith studies. This is evidenced by his activities in writing works such as a collection of hadiths, <em>sharh</em>s, and collections of hadith <em>arba’in</em> which became the trend of previous scholars. In addition, Gumushanevi also had a very large contribution to the continuity of the study of hadith in Ottoman society through his works and students.]</p>