bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ecotourism intention: the roles of environmental concern, time perspective and destination image
Authors: Pham Hanh Song Thi , Khanh Chi Nguyen Thi 
Published: July 2020

Purpose
This study aims to examine the decisive factors that affect travellers’ intention to visit ecotourism destinations.

Design/methodology/approach
Convenience sampling method was used to develop a research sample. The research sample includes visitors at eight ecotourism destinations in Vietnam who were randomly approached and agreed to participate in a structured questionnaire survey. The data set consists of 431 valid responses. A multivariate analysis method was used to analyse the data.

Findings
This study finds strong correlations between three factors that are important in determining the Vietnamese travellers’ intention to visit ecotourism locations. These are environmental concern, future time perspective (defined as individual views towards the importance of future time) and eco-destinations image (understood as individual perceptions of an ecotourism place). This study also reports robust associations between eco-destination image, future time perspective and environmental concern.

Practical implications
This study suggests policymakers in an emerging economy such as Vietnam to use efficient regulations on protecting the natural environment in tourism locations while tourism providers and marketers should invest in building eco-image of travel locations. This study also recommends public organisations to encourage greater awareness of the importance of environmental protection through education, propaganda and media as this will foster the demand for ecotourism. Last but not least, this study advises tourism marketers to develop marketing materials emphasising future time perspective and eco-destination images if they wish to promote ecotourism.

Originality/value
This study highlights the influential role of travellers’ future time perspective and eco-destination image in their travel intention. The existing literature does not pay sufficient attention to the impacts that these two considerations have on travellers’ environmental concerns and consequently stimulate their intention to visit ecotourism destinations. This study suggests relevant management strategies for the development of ecotourism in emerging economies.
Modelling of viscoacoustic wave propagation in transversely isotropic media using decoupled fractional Laplacians
Authors: Qiao Zhihao , Sun Chengyu , Tang Jie 
Published: July 2020

ABSTRACTA new wave equation is derived for modelling viscoacoustic wave propagation in transversely isotropic media under acoustic transverse isotropy approximation. The formulas expressed by fractional Laplacian operators can well model the constant‐Q (i.e. frequency‐independent quality factor) attenuation, anisotropic attenuation, decoupled amplitude loss and velocity dispersion behaviours. The proposed viscoacoustic anisotropic equation can keep consistent velocity and attenuation anisotropy effects with that of qP‐wave in the constant‐Q viscoelastic anisotropic theory. For numerical simulations, the staggered‐grid pseudo‐spectral method is implemented to solve the velocity–stress formulation of wave equation in the time domain. The constant fractional‐order Laplacian approximation method is used to cope with spatial variable‐order fractional Laplacians for efficient modelling in heterogeneous velocity and Q media. Simulation results for a homogeneous model show the decoupling of velocity dispersion and amplitude loss effects of the constant‐Q equation, and illustrate the influence of anisotropic attenuation on seismic wavefields. The modelling example of a layered model illustrates the accuracy of the constant fractional‐order Laplacian approximation method. Finally, the Hess vertical transversely isotropic model is used to validate the applicability of the formulation and algorithm for heterogeneous media.
Policy and management actions that resulted in curbing rhinoceros poaching
Authors: Acharya Krishna Prasad , Thapa Ramesh Kumar , Kuwar Kamal Jung , Thapalia Bishnu Prasad , Paudel Prakash Kumar 
Published: July 2020

Abstract

Nepal almost eliminated poaching of the greater one‐horned rhinoceros Rhinoceros unicornis over the past decade, although poaching of other rhinoceros species remains a major problem in other Asian countries, as well as in Africa.

It is important to understand the processes leading to declines in poaching in Nepal that may provide insight into possible anti‐poaching interventions in other parts of world.

We argue that coordinated actions that led to (a) strengthened institutional mechanisms, (b) improved community participation and (c) enhanced interagency coordination all focused on dismantling illegal trade networks contributed to curbing poaching in Nepal.

The Government of Nepal (GoN) created a new institutional mechanism both at central and district levels aimed at formulating policies and collaborating with enforcement agencies. Security agencies (Nepal Police and Army) were given responsibilities in and around rhinoceros habitat, and local citizens, mostly youths, were involved in surveillance and reporting of poaching activities. Targeted arrests and prosecutions were carried out that resulted in much higher conviction rates than previously.

Synthesis and applications. Nepal's achievement in curbing rhinoceros poaching is a result of the collective and coordinated action of multiple stakeholders. Interagency coordination brought together the strength of each stakeholder, making it possible to fill critical gaps in anti‐poaching campaigns. There is a need for continued engagement of local communities, interagency cooperation and better training of law enforcement staff to sustain past achievements.
Macrofungi: A review of cultivation strategies, bioactivity, and application of mushrooms
Authors: Lu Hongyun , Lou Hanghang , Hu Jingjin , Liu Zhengjie , Chen Qihe 
Published: July 2020

AbstractThe production of macrofungi (mushrooms) as well as their economic value have been steadily increasing globally. The use of functional foods, dietary supplements, and traditional medicines derived from macrofungi is increasing as they have numerous health benefits as well as abundant nutrients. Macrofungi are diverse with complex and highly varied growth conditions and bioactive constituents, most macrofungal resources have not yet been fully explored and applicated, leading to an urgent need for appropriate strategies to address the problem. Increasing attention has been paid to the macrofungal cultivation and application, in particular, potential prebiotics. Herein, the present review comprehensively summarizes recent progress in the cultivation, newly identified bioactive constituents, and their effects on gut microbiota as well as the potential ways in which they affect human health. Moreover, the macrofungal food development is discussed to improve food nutritional value and change the quality characteristics of food. Finally, the review addresses consumer safety concerns and the prospective genetic manipulation of macrofungi. We hope that this review can provide a comprehensive research reference for ensuring the safety and efficacy, along with maximizing the value and profitability of macrofungi production.
Osimertinib for compound EGFR exon 19 deletion/T790M mutated lung squamous cell carcinoma
Authors: Peng MuYun , Wen QiuYuan , Wu Xia , Yu FengLei , Liu WenLiang 
Published: July 2020

AbstractThe role of the epidermal growth factor receptor (EGFR) mutation status testing in lung squamous cell carcinoma (SqCC) remains controversial. Evidence of the effectiveness of osimertinib in SqCC with EGFR T790M mutation is limited. Here, we describe a hitherto unreported case of a stage III SqCC patient with compound mutation of EGFR exon 19 deletion (19Del) and T790M mutation. Pathological complete tumor response was achieved after treatment with osimertinib. We suggest that EGFR mutation testing should be performed in Asian patients who have not been definitively diagnosed with SqCC due to small lung biopsy samples. Osimertinib has shown good efficacy in SqCC harboring a “primary” resistance mechanism (EGFR T790M).Key pointsAn unreported case of stage III squamous cell carcinoma with synchronous occurrence of EGFR exon 19 deletion (19Del) and T790M mutation. Complete tumor response was achieved after treatment with osimertinib.EGFR mutation testing should be performed in Asian patients who are not definitively diagnosed with SqCC due to small lung biopsy samples. Osimertinib has shown good efficacy in SqCC harboring a “primary” resistance mechanism (EGFR T790M).
Demand, challenges, and marketing strategies in the retail promotion of local brand milk
Authors: Liu Yizao , Chen Xuan , Rabinowitz Adam N. , Campbell Benjamin 
Published: July 2020

AbstractThis article addresses the demand and challenges for local brand milk and focuses on the marketing strategies for retail promotion. While federal and state government make efforts to promote local food purchases and consumption at the farm level, local foods face significant distribution challenges in grocers, especially in larger retail stores. Limited shelf space and high pricing by retailers impedes consumers’ purchases and results in weak competitiveness for local brands. Therefore, it is essential for local producers and “buy local” programs to understand what types of promotion and marketing strategies might be more effective in stimulating demand in retail outlets. Using 2010‐2011 Nielsen Retail Scanner data in the Northeast region, we estimate a random‐coefficient discrete choice model of demand to determine the effects of nutritional characteristics, price, packaging, and distribution strategies on the consumers’ choice to purchase locally branded milk. Results show that local brand milk faces significant demand challenges in addition to high prices and limited outlets in competing with lower‐priced products. Marketing strategies, such as price cut, one‐gallon package offering, and expanded presence in retail stores, can significantly stimulate the demand for locally branded milk, with one‐gallon package offering being the most effective strategy.
Populations of in silico myocytes and tissues reveal synergy of multiatrial‐predominant K+‐current block in atrial fibrillation
Authors: Ni Haibo , Fogli Iseppe Alex , Giles Wayne R. , Narayan Sanjiv M. , Zhang Henggui , Edwards Andrew G. , Morotti Stefano , Grandi Eleonora 
Published: July 2020

Background and PurposePharmacotherapy of atrial fibrillation (AF), the most common cardiac arrhythmia, remains unsatisfactory due to low efficacy and safety concerns. New therapeutic strategies target atrial‐predominant ion‐channels and involve multichannel block (poly)therapy. As AF is characterized by rapid and irregular atrial activations, compounds displaying potent antiarrhythmic effects at fast and minimal effects at slow rates are desirable. We present a novel systems pharmacology framework to quantitatively evaluate synergistic anti‐AF effects of combined block of multiple atrial‐predominant K+ currents (ultra‐rapid delayed rectifier K+ current, IKur, small conductance Ca2+‐activated K+ current, IKCa, K2P3.1 2‐pore‐domain K+ current, IK2P) in AF.Experimental ApproachWe constructed experimentally calibrated populations of virtual atrial myocyte models in normal sinus rhythm and AF‐remodelled conditions using two distinct, well‐established atrial models. Sensitivity analyses on our atrial populations was used to investigate the rate dependence of action potential duration (APD) changes due to blocking IKur, IK2P or IKCa and interactions caused by blocking of these currents in modulating APD. Block was simulated in both single myocytes and one‐dimensional tissue strands to confirm insights from the sensitivity analyses and examine anti‐arrhythmic effects of multi‐atrial‐predominant K+ current block in single cells and coupled tissue.Key ResultsIn both virtual atrial myocytes and tissues, multiple atrial‐predominant K+‐current block promoted favourable positive rate‐dependent APD prolongation and displayed positive rate‐dependent synergy, that is, increasing synergistic antiarrhythmic effects at fast pacing versus slow rates.Conclusion and ImplicationsSimultaneous block of multiple atrial‐predominant K+ currents may be a valuable antiarrhythmic pharmacotherapeutic strategy for AF.
Identification of potential modulators of osteosarcoma metastasis by high‐throughput cellular screening of natural products
Authors: Long Sarah A. , Huang Shan , Kambala Anusha , Ren Ling , Wilson Jennifer , Goetz Michael , Hao Xiaojiang , Yang Xiaosheng , Goncharova Ekaterina I. , Jia Libin , LeBlanc Amy , Khanna Chand , Henrich Curtis J. , Beutler John A. 
Published: July 2020

AbstractA high‐throughput screening assay was developed and applied to a large library of natural product extract samples, in order to identify compounds which preferentially inhibited the in vitro 2D growth of a highly metastatic osteosarcoma cell line (MG63.3) compared to a cognate parental cell line (MG63) with low metastatic potential. Evaluation of differentially active natural product extracts with bioassay‐guided fractionation led to the identification of lovastatin (IC50 = 11 µm) and the limonoid toosendanin (IC50 = 26 nm). Other statins and limonoids were then tested, and cerivastatin was identified as a particularly potent (IC50 < 0.1 µm) and selective agent. These compounds potently and selectively induced apoptosis in MG63.3 cells, but not MG63. Assays with other cell pairs were used to examine the generality of these results. Statins and limonoids may represent unexplored opportunities for development of modulators of osteosarcoma metastasis. As cerivastatin was previously approved for clinical use, it could be considered for repurposing in osteosarcoma, pending validation in further models.
Patch testing with a textile dye mix with and without Disperse Orange 3
Authors: Stenton Joanna , Dahlin Jakob , Antelmi Annarita , Bruze Magnus , Svedman Cecilia , Zimerson Erik , Hamnerius Nils , Pontén Ann , Isaksson Marléne 
Published: July 2020

AbstractBackgroundThe textile dye mix (TDM) 6.6% pet. contains Disperse Blue (DB) 35, Disperse Yellow 3, Disperse Orange (DO) 1 and 3, Disperse Red 1 and 17, and DB 106 and 124. The most frequent allergen in TDM‐positive patients is DO 3. Around 85% of p‐phenylenediamine (PPD)‐allergic dermatitis patients have shown positive patch test reactions to DO 3. There has been a discussion to exclude DO 3 from TDM 6.6% because of frequent, strong reactions to TDM 6.6% and PPD.ObjectivesTo study if DO 3 can be omitted from a TDM.MethodsPatch tests were performed on 2250 dermatitis patients with TDM 6.6%, TDM 5.6% pet., TDM 7.0% pet., and PPD 1.0% pet.; 122 patients were also patch tested with DO 3 1.0% pet.ResultsAmong the 2250 patients patch tested, contact allergy prevalence to TDM 6.6% was 2.4%, to TDM 5.6% 1.8%, and to TDM 7.0% 2.0%. Of the 54 TDM 6.6%‐positive patients, 55.6% reacted to PPD; as much as 42.2% of PPD‐allergic women and 50% of PPD‐allergic men reacted to TDM 6.6%. Of the 17 DO 3‐positive patients, 94.1% showed a positive reaction to PPD.ConclusionResults indicate that DO 3 can probably be omitted from TDM, but patch testing with TDM 6.6%, TDM 7.0%, DO 3 1.0%, and PPD 1.0% simultaneously is needed to finally decide whether it is possible or not.
Fishes and cowboy boots: An optimistic view
Authors: de Araujo Lima Constantino Pedro , Silvius Kirsten , Alvarenga Fernanda , Isis Buck Silva Cristina , Kurihara Leonardo , Rossoni Felipe , Torres Ana Claudia , Dias da Costa Antônio Adevaldo , Quizia Corrêa Mota Sara , Nunes Rocha João da Mata , De Vita Silva Santos Bruna , Campos‐Silva João Vitor 
Published: July 2020

AbstractThe community‐based management of Arapaima gigas for sustainable commercial use allows that wild fish legally harvested in the Brazilian Amazon supply the demand for exotic leather in the US, supporting the conservation of the forest and providing income for fishers communities if based in fair‐trade. We provide a more optimistic view than Heinrich et al. (2019) on the effects of international trade of arapaima leather in the conservation of the species in Brazil.
Characterising the increasing prevalence of crystal methamphetamine use in Vancouver, Canada, from 2006–2017: A gender‐based analysis
Authors: Bach Paxton , Hayashi Kanna , Milloy M‐J , Nosova Ekaterina , Kerr Thomas , Wood Evan , Fairbairn Nadia 
Published: July 2020

AbstractIntroductionMethamphetamine use is increasing in North America and is associated with numerous negative health effects and social harms. As drug‐related harms are often gendered, this study sought to examine the differential impacts of gender on the trends, risk factors and health implications of crystal methamphetamine use among a Canadian cohort of people with high rates of injection polysubstance use.MethodsData were collected from two prospective cohorts of people who inject drugs in Vancouver, Canada. We examined trends in reported crystal methamphetamine use from 2006–2017 using the Cochrane‐Armitage test for trend. We used multivariable generalised estimating equations, stratified by gender, to determine independent risk factors and health outcomes associated with crystal methamphetamine use.ResultsIn total, 1984 participants were included in the study, including 694 (35%) women. The prevalence of reported crystal methamphetamine use within the previous 6 months rose from 19% in 2006 to 36% in 2017, with a rise seen in both genders (P < 0.001). Reported crystal methamphetamine use was associated with numerous risk behaviours and drug‐related harms in both genders, and in women it was associated with an increase in experiences of sexual violence (adjusted odds ratio 1.64, 95% confidence interval 1.18, 2.27).ConclusionsThese findings demonstrate the rising prevalence of reported crystal methamphetamine use in Vancouver in a cohort with high rates of polysubstance use. This work highlights drug and sex‐related risk behaviours associated with crystal methamphetamine use for both genders, and underscores the need to develop strategies to address the growing use of crystal methamphetamine.
Habitat availability and environmental preference drive species range shifts in concordance with climate change
Authors: Li Fengqing , Park Young‐Seuk 
Published: July 2020

AbstractAimA progressive increase in air temperature is recognized as the most important mechanistic driver of species range shifts. However, only a few studies have simultaneously considered the influence of both extrinsic and intrinsic mechanistic drivers; there are still no studies on the roles of extrinsic and intrinsic drivers that regulate such species changes. We investigated how species will shift their geographical ranges to cope with future climate change and analysed the relative importance of the mechanistic drivers in governing species range shifts.LocationSixteen countries in South, West and North Europe.MethodsWe used ensemble species distribution models on the European continental scale to predict 105 odonate species in response to climate change in the future decades until 2080s under three emission scenarios. We evaluated the projected changes in four community metrics (distribution area, optimum position, leading edge and trailing edge) and investigated how these changes are driven by extrinsic and intrinsic factors.ResultsThe odonate species were predicted to shift their range margins poleward, with a higher migration rate towards the trailing edge (2.38‒10.34 km/year) than the leading edge (1.13‒2.00 km/year). Contrary to the assumption that the response of the odonate species to climate change will linearly accelerate over time, the distribution areas of odonate species were predicted to increase until 2050s and then decline until 2080s under RCP 2.6 (representative concentration pathway). However, their distributions under RCP 4.5 and RCP 8.5 were predicted to decrease over time, with a higher rate under RCP 8.5. Overall, environmental preference and habitat override dispersal ability govern the range shift of odonate species.Main conclusionsQuantifying the relative importance of extrinsic and intrinsic factors across a large spatial scale under different emission scenarios can help understand the mechanistic processes to facilitate species range shifts.
The development of an epilepsy electronic patient portal: Facilitating both patient empowerment and remote clinician‐patient interaction in a post‐COVID‐19 world
Authors: Power Kevin , McCrea Zita , White Maire , Breen Annette , Dunleavy Brendan , O’Donoghue Sean , Jacquemard Tim , Lambert Veronica , El‐Naggar Hany , Delanty Norman , Doherty Colin , Fitzsimons Mary 
Published: July 2020

AbstractObjectivesThe current coronavirus disease 2019 (COVID‐19) pandemic stresses an urgency to accelerate much‐needed health service reform. Rapid and courageous changes being made to address the immediate impact of the pandemic are demonstrating that the means and technology to enable new models of health care exist. For example, innovations such as electronic patient portals (ePortal) can facilitate (a) radical reform of outpatient care; (b) cost containment in the economically constrained aftermath of the pandemic; (c) environmental sustainability by reduction of unnecessary journeys/transport. Herein, the development of Providing Individualised Services and Care in Epilepsy (PiSCES), an ePortal to the Irish National Epilepsy Electronic Patient Record, is demonstrated. This project, which pre‐dates the COVID‐19 crisis, aims to facilitate better patient‐ and family‐centered epilepsy care.MethodsA combination of ethnographic research, document analysis, and joint application design sessions was used to elicit PiSCES requirements. From these, a specification of desired modules of functionality was established and guided the software development.ResultsPiSCES functional features include “My Epilepsy Care Summary,” “My Epilepsy Care Goals,” “My Epilepsy Clinic Letters,” “Help Us Measure Your Progress,” “Prepare For Your Clinic Visit,” “Information for Your Healthcare Provider.” The system provides people with epilepsy access to, and engages them as co‐authors of, their own medical record. It can promote improved patient‐clinician partnerships and facilitate patient self‐management.SignificanceIn the aftermath of COVID‐19, it is highly unlikely that the healthcare sector will return to a “business as usual” way of delivering services. The pandemic is expected to accelerate adoption of innovations like PiSCES. It is therefore a catalyst for change that will deliver care that is more responsive to individual patient needs and preferences.