bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of velopharyngeal dysfunction in 22q11.2 deletion syndrome: A retrospective case-control study
Authors: Failla Sebastiano , You Peng , Rajakumar Chandheeb , Dworschak-Stokan Anne , Doyle Philip C. , Husein Murad 
Published: July 2020

Objective To identify and describe the dynamic features of velopharyngeal dysfunction (VPD) in patients with 22q11.2 deletion syndrome relative to patients with non-syndromic cleft palates. Study design Retrospective case-control study. Setting Pediatric tertiary care center. Subjects and methods A total of 30 children (aged 9–16 years) with VPD were included in this study. Fifteen children with a definitive diagnosis of 22q11.2 deletion syndrome requiring surgical VPD repair were included in the 22q11.2 deletion syndrome group. Fifteen age- and sex-matched children with non-syndromic cleft palate requiring surgical VPD repair were included in the non-syndromic cleft palate group for comparison. Velar displacement, lateral pharyngeal wall displacement, and lateral pharyngeal wall motion pattern data were extracted from preoperative Multiview Videofluoroscopy imaging studies of all children and compared across groups. Results Lateral pharyngeal wall displacement was found to be reduced in the 22q11.2 deletion syndrome group (U = 29.50, p = .001, r = .63). However, measures of velar displacement were not observed to differ between groups. Similarly, lateral pharyngeal wall motion pattern distributions were not found to differ across these two groups. Conclusions Velopharyngeal dysfunction in patients with 22q11.2 deletion syndrome showed differences in dynamic velopharyngeal function when compared to non-syndromic cleft palate patients. The current findings provide initial insights into the unique aspects of velopharyngeal dysfunction for patients with 22q11.2 deletion syndrome. These findings may guide further efforts directed toward understanding the dynamic velopharyngeal characteristics of this population and potentially optimize surgical management and functional outcomes.
The 3D annotated scans method: a new approach to ship timber recording
Authors: Van Damme Thomas , Auer Jens , Ditta Massimiliano , Grabowski Michał , Couwenberg Marie 
Published: July 2020

Abstract
Every year, maritime archaeologists around the globe are faced with the daunting task of recording hundreds, if not thousands, of individual ship timbers. The in-depth recording of ship timbers is a process which is both challenging and laborious, but it is an indispensable step in order to fully understand the construction of the ship the timbers formed a part of, and as archaeologists it is our duty to document all the information these complex artefacts hold to the best of our abilities. In this article, the authors first provide an overview of the methods currently in use for ship timber recording, namely 2D scaled drawing, 2D tracing, 3D contact digitising and 3D scanning. The respective advantages and limitations of these methods are then discussed in light of the various scientific and practical considerations that go into choosing a recording method for a project. Next, a new approach to ship timber recording, termed the “3D annotated scans method”, is introduced and discussed using a recent case study in northern Germany. At its core the method consists of two phases; a 3D scanning phase in which the timber is scanned in 3D, followed by a 3D annotation phase in which the recorder interprets the timber by tracing diagnostic features such as fasteners and toolmarks directly onto the timber’s digital model. The authors conclude that this new approach represents an improvement over current methods—both in terms of the quality of the scientific outputs and in terms of recording efficiency—and that, besides being implemented for the recording of ship timbers, the same method can also be used for a wide range of other heritage applications.
The diagnostic potential of low-field MRI in problematic total knee arthroplasties - a feasibility study
Authors: Schröder Femke F. , Post Corine E. , van Raak Sjoerd M. , Simonis Frank F. J. , Wagenaar Frank-Christiaan B. M. , Huis in’t Veld Rianne M. H. A. , Verdonschot Nico 
Published: July 2020

Abstract
Purpose
Low-field MRI, allowing imaging in supine and weight-bearing position, may be utilized as a non-invasive and affordable tool to differentiate between causes of dissatisfaction after TKA (‘problematic TKA’). However, it remains unclear whether low-field MRI results in sufficient image quality with limited metal artefacts. Therefore, this feasibility study explored the diagnostic value of low-field MRI concerning pathologies associated with problematic TKA’s’ by comparing low-field MRI findings with CT and surgical findings. Secondly, differences in patellofemoral parameters between supine and weight-bearing low-field MRI were evaluated.

Methods
Eight patients with a problematic TKA were scanned using low-field MRI in weight-bearing and supine conditions. Six of these patients underwent revision surgery. Scans were analysed by a radiologist for pathologies associated with a problematic TKA. Additional patellofemoral and alignment parameters were measured by an imaging expert. MRI observations were compared to those obtained with CT, the diagnosis based on the clinical work-up, and findings during revision surgery.

Results
MRI observations of rotational malalignment, component loosening and patellofemoral arthrosis were comparable with the clinical diagnosis (six out of eight) and were confirmed during surgery (four out of six). All MRI observations were in line with CT findings (seven out of seven). Clinical diagnosis and surgical findings of collateral excessive laxity could not be confirmed with MRI (two out of eight).

Conclusion
Low-field MRI shows comparable diagnostic value as CT and might be a future low cost and ionizing radiation free alternative. Differences between supine and weight-bearing MRI did not yield clinically relevant information.
The study was approved by the Medical Research Ethics Committees of Twente (Netherlands Trial Register: Trial NL7009 (NTR7207). Registered 5 March 2018, https://www.trialregister.nl/trial/7009).
Multimodal therapy with surgery and adjuvant nivolumab for late-onset multiple liver metastases of choroidal malignant melanoma: a case report
Authors: Muraki Ryuta , Morita Yoshifumi , Ida Shinya , Kitajima Ryo , Furuhashi Satoru , Kiuchi Ryota , Takeda Makoto , Kikuchi Hirotoshi , Hiramatsu Yoshihiro , Sakaguchi Takanori , Kasuya Akira , Hotta Yoshihiro , Takeuchi Hiroya 
Published: July 2020

Abstract
Background
Choroidal malignant melanoma is the most common primary malignant tumor of the eye in adults. Prognosis after recurrence of this disease has been dismal because of the absence of an effective therapy. However, resection of recurrent foci and a subsequent treatment with immune-checkpoint inhibitor may improve the prognosis after recurrence of this disease. This study presents a case of late-onset liver metastases of choroidal malignant melanoma, successfully treated with hepatectomy and postoperative adjuvant nivolumab.

Case presentation
A 53-year-old woman had undergone left ocular enucleation because of choroidal malignant melanoma 13 years prior to admission. She visited a nearby clinic with complaints of epigastric pain. She was referred to our hospital because a giant liver tumor was observed on abdominal ultrasonography. Enhanced computed tomography revealed multiple liver tumors in the right lobe, 49 mm in diameter with ring enhancement in subsegment (S) 5/6, and 14 and 8 mm without any enhancement in S7 and S5, respectively. On magnetic resonance imaging, the main tumor showed high intensity on T1-weighted with fat suppression, suggesting melanin deposition. Based on the diagnosis of multiple liver metastases of choroidal malignant melanoma, right hepatectomy and regional lymphadenectomy were performed. She was discharged without postoperative complications. Histological examination revealed that all tumors were metastatic malignant melanoma. She was treated with nivolumab postoperatively, and no recurrences were observed during 22 months of follow-up.

Conclusions
Aggressive surgery plus adjuvant nivolumab appears to be a promising treatment for choroidal malignant melanoma with late-onset liver metastases.
Effects of live and video simulation on clinical reasoning performance and reflection
Authors: Cleary Timothy J. , Battista Alexis , Konopasky Abigail , Ramani Divya , Durning Steven J. , Artino Anthony R. 
Published: July 2020

AbstractIntroductionIn recent years, researchers have recognized the need to examine the relative effectiveness of different simulation approaches and the experiences of physicians operating within such environments. The current study experimentally examined the reflective judgments, cognitive processing, and clinical reasoning performance of physicians across live and video simulation environments.MethodsThirty-eight physicians were randomly assigned to a live scenario or video case condition. Both conditions encompassed two components: (a) patient encounter and (b) video reflection activity. Following the condition-specific patient encounter (i.e., live scenario or video), the participants completed a Post Encounter Form (PEF), microanalytic questions, and a mental effort question. Participants were then instructed to re-watch the video (i.e., video condition) or a video recording of their live patient encounter (i.e., live scenario) while thinking aloud about how they came to the diagnosis and management plan.ResultsAlthough significant differences did not emerge across all measures, physicians in the live scenario condition exhibited superior performance in clinical reasoning (i.e., PEF) and a distinct profile of reflective judgments and cognitive processing. Generally, the live condition participants focused more attention on aspects of the clinical reasoning process and demonstrated higher level cognitive processing than the video group.ConclusionsThe current study sheds light on the differential effects of live scenario and video simulation approaches. Physicians who engaged in live scenario simulations outperformed and showed a distinct pattern of cognitive reactions and judgments compared to physicians who practiced their clinical reasoning via video simulation. Additionally, the current study points to the potential advantages of video self-reflection following live scenarios while also shedding some light on the debate regarding whether video-guided reflection, specifically, is advantageous. The utility of context-specific, micro-level assessments that incorporate multiple methods as physicians complete different parts of clinical tasks is also discussed.
Impact of maternal diabetes and obesity on fetal cardiac functions
Authors: Bayoumy Suzan , Habib Marwa , Abdelmageed Randa 
Published: July 2020

Abstract
Background
In several developing industrial countries, the incidence of obesity among populations is spreading quickly and dramatically; also, the frequency of maternal obesity is in continuous elevation, which represents a considerable public health problem. Maternal hyperglycemia is a common gestational risk factor for the fetus. Several studies proposed that maternal DM and obesity lead to intrauterine impacts which induce changes in the fetal myocardium, and the pre-pregnancy obesity and diabetes are accompanied with development of cardiovascular alterations in the offspring and subsequent pathological changes in their early life. The aim of this study is to assess the cardiac function in fetuses of obese pregnant women (FOW) and fetuses of diabetic women (FDW) in comparison with fetuses of normal pregnant women (FNW) using tissue Doppler imaging.

Results
There was impairment in systolic and diastolic cardiac function in both fetuses of obese and diabetic women with decreased global longitudinal strain tissue Doppler velocities at 30 weeks of gestation compared to fetuses of normal women.

Conclusion
Imaging of the fetus of pregnant women by Echo Doppler at about 30 weeks of gestations showed a reduced cardiac function of fetuses of obese and diabetic women matched with fetuses of normal BMI women. Our finding proposed that early subclinical alterations in the fetal cardiac output can arise from maternal obesity alone. This explains the predilection of children of obese mothers at advanced ages to cardiovascular disorder.
A new bonded silica based on an amino acid derivative as a TLC stationary phase to solve nitrophenol structural isomerism and ibuprofen stereoisomerism
Authors: Abu Rasheed Mouhammad , Alshaghel Ahmad , Sakur Amir Alhaj 
Published: July 2020

Abstract
Background
Many amino acids and their derivatives have been used previously as chiral selectors in thin layer chromatography. Herein, we reported the synthesis, characterization, and chromatographic evaluation of a new modified stationary phase based on (S)-3-(aminomethyl)-5-methylhexanoic acid (also known as pregabalin) as an amino acid ligand bonded to the silica surface via triazine attachment.

Results
SC-2P (silica-cyanuric-2-pregabalin) is a bonded silica stationary phase prepared by direct binding of the pre-synthesized cyanuric-2-pregabalin organic ligand on the chlorinated silica surface. FT-IR and UV diffuse reflection spectroscopy (UV-DRS) were used to characterize the synthesized bonded phase, and the specific surface area was determined using the methylene blue Langmuir isotherm method to be 147.04 m2/g. TLC plates were prepared from a slurry of this synthesized material with 2 mM of Cu2+ as a selector additive, and the chromatographic characteristics of these plates were investigated to separate a ternary mixture of o-, m-, and p-nitrophenol as structural isomers, and a racemic mixture of (±)-ibuprofen as stereoisomers. Solvent systems of n-hexane:dichloroethane:n-propanol (75:20:5, v/v/v) and Dichloroethane:acetonitrile (90:10, v/v) were selected as mobile phases for nitrophenol and ibuprofen mixtures, respectively. The successful separation was densitometrically confirmed, and retardation factors (Rf) were determined for o-, m-, and p-nitrophenol at 320 nm to be 0.83, 0.45, and 0.28, and for R(−)-, S(+)-ibuprofen at 220 nm to be 0.43 and 0.63, respectively.

Conclusion
The synthesis, characterization, and chromatographic evaluation of SC-2P were reported in this article. SC-2P was used with copper ions to form in situ ligand exchange reagent (LER), which was successfully employed to solve an isomeric mixture of nitrophenol and a racemic mixture of (±)-ibuprofen. The synthesized stationary phase showed high repeatability with minimum Rf shifts between batches.
Successful Implementation of a Quality Improvement Intervention Toward a QOPI-Certified Breast Cancer Center in Mexico
Authors: Peña-Curiel Omar , Villarreal-Garza Cynthia , Canavati Mauricio , Velazquez-Ayala Karen Marlene , Castro-Carrasco Janeth , Garza-Ledezma María Alejandra , Zarzar-Handal Katia , Díaz-Pérez Héctor Marcelino , De la Garza-Ramos Cynthia , Ferrigno Ana S. , Martínez Enrique Francisco , Guerrier Vedner 
Published: July 2020

INTRODUCTION: As part of a quality improvement (QI) project undertaken during the 2018 edition of the American Society of Clinical Oncology’s Quality Training Program (QTP), we evaluated our practice’s compliance to 70 measures regarding the Core, Symptom/Toxicity and Breast Cancer modules from the Quality Oncology Practice Initiative (QOPI) database. Thirteen measures were identified as being consistently low in documentation rate in our medical records (MR). METHODS: After establishing a multidisciplinary QI team, we defined to accomplish 100% documentation rate of these 13 QOPI measures in ≥ 80% of the monthly new patient MRs during the 6-month QTP. We designed a Microsoft Word MR template and implemented a new pre-consultation process. Monthly Plan-Do-Study-Act cycles were conducted to assess the performance of the intervention. RESULTS: After the 6-month QI intervention, > 80% of our monthly MRs achieved 100% compliance to the aimed-for 13 QOPI measures. Furthermore, our new pre-consultation process proved to be valuable in facilitating the documentation of data without interfering with the oncology appointment. CONCLUSION: The development of a systematic QI approach effectively enhanced our compliance to 13 QOPI measures over a 6-month period. These results led to the standardization of the current model of care at our institution. To our knowledge, Hospital Zambrano Hellion’s Breast Cancer Center is the first Mexican cancer center to pursue a QOPI certified practice.
Role of Ovarian Hormones in the Modulation of Sleep in Females Across the Adult Lifespan
Authors: Brown Alana M C , Gervais Nicole J 
Published: July 2020

Abstract
Ovarian hormones, including 17β-estradiol, are implicated in numerous physiological processes, including sleep. Beginning at puberty, girls report more sleep complaints than boys, which is maintained throughout the reproductive life stage. Sleep problems are exacerbated during the menopausal transition, evidenced by greater risk for sleep disorders. There is emerging evidence that menopause-associated hormone loss contributes to this elevated risk, but age is also an important factor. The extent to which menopause-associated sleep disturbance persists into postmenopause above and beyond the effects of age remains unknown. Untreated sleep disturbances have important implications for cognitive health, as they are emerging as risk factors for dementia. Given that sleep loss impairs memory, an important knowledge gap concerns the role played by menopause-associated hormone loss in exacerbating sleep disturbance and, ultimately, cognitive function in aging women. In this review, we take a translational approach to illustrate the contribution of ovarian hormones in maintaining the sleep–wake cycle in younger and middle-aged females, with evidence implicating 17β-estradiol in supporting the memory-promoting effects of sleep. Sleep physiology is briefly reviewed before turning to behavioral and neural evidence from young females linking 17β-estradiol to sleep–wake cycle maintenance. Implications of menopause-associated 17β-estradiol loss is also reviewed before discussing how ovarian hormones may support the memory-promoting effects of sleep, and why menopause may exacerbate pathological aging via effects on sleep. While still in its infancy, this research area offers a new sex-based perspective on aging research, with a focus on a modifiable risk factor for pathological aging.
Trends and Outcomes in Pediatric Patients Undergoing Scoliosis Repair: A Population-Based Study
Authors: DelPizzo Kathryn , Wilson Lauren A. , Fiasconaro Megan , Liu Jiabin , Bekeris Janis , Poeran Jashvant , Memtsoudis Stavros G. 
Published: July 2020

BACKGROUND:
Although surgery represents the only definitive treatment for congenital scoliosis, comprehensive information regarding trends in perioperative complications, particularly in the pediatric setting, is lacking. We sought to identify trends in and factors associated with perioperative complications following pediatric scoliosis surgery.

METHODS:
In this retrospective cohort study, patients below the age of 21 years undergoing a scoliosis repair procedure were identified from the Premier Healthcare database (2006–2016). The primary outcomes of interest were any complication, cardiopulmonary complications, blood transfusions, intensive care unit (ICU) admission, length of stay (LOS), and cost of hospitalization. Trends in these outcomes over time were analyzed. Multivariable logistic regression models were run to identify factors associated with each of the perioperative outcomes.

RESULTS:
In the full cohort of 9351 scoliosis patients, 17% experienced any complication, 12% of which were cardiopulmonary in nature, 42% required blood transfusions, and 62% were admitted to the ICU. Median LOS was 5 days (interquartile range [IQR], 4–6) and median cost was $56,375 (IQR, $40,053–$76,311). Annual incidence of complications and blood transfusions as well as LOS and cost decreased significantly throughout the study period. The most consistently observed factors associated with complications were younger age, high comorbidity burden, low institutional case volume, and hospital teaching status.

CONCLUSIONS:
Although the incidence of the studied adverse outcomes in scoliosis surgery has decreased over time, this study shows it remains relatively high (17%). The associations demonstrated help clarify factors associated with complications and may be useful in guiding interventions to improve outcomes.
Creolizing Transylvania
Authors: Boatcă Manuela , Parvulescu Anca 
Published: July 2020

AbstractThis article analyzes the differences and overlaps between the dynamics of coloniality and inter-imperiality that have shaped Transylvania since the sixteenth century vis-à-vis neighboring European peripheries and shifting cores, zooming in on how the tensions between different modes of colonial and imperial rule play out in rural settings. We foreground the vantage point of the rural by focusing on a Transylvanian village in 1920 as a global countryside.
“A Strange Industrial Order”
Authors: Tilley Lisa 
Published: July 2020

AbstractThe plantation continues to expand across contemporary frontiers, remaking social orders and ravaging ecologies in the service of value extraction through commodity production. This article revisits the “strange industrial order” of the plantation in 1950s Indonesia at a time of deep contestation in which estate workers were organizing to reinvigorate the unfulfilled goals of anticolonial struggles. Reading this moment through the anxieties of European planters in the British archive, this article argues that these struggles deeply disturbed the localized racial labor order of the plantation, while also working against the extractive tributaries of the international order. Further, the article suggests that keeping alive a historical consciousness around how industrial racial regimes are produced, disturbed, and fractured is vital to countering the harms of our plantation present.
The lncRNA MEG3 mediates renal cell cancer progression by regulating ST3Gal1 transcription and EGFR sialylation
Authors: Gong Aihong , Zhao Xinyu , Pan Yue , Qi Yu , Li Shuangda , Huang Yiran , Guo Yanru , Qi Xia , Zheng Wei , Jia Li 
Published: July 2020

ABSTRACT
Long noncoding RNAs (lncRNAs) have emerged as important regulators of cancer progression. Abnormal sialylation leads to renal cell carcinoma (RCC) malignancy. However, the mechanism by which the lncRNA maternally expressed gene 3 (MEG3) mediates RCC progression by regulating ST3Gal1 transcription and EGFR sialylation is still unrevealed. Here, we found that the expression of MEG3 was higher in adjacent tissues than in RCC tissues, as well as downregulated in RCC cell lines compared to expression in normal renal cells. The proliferation, migration and invasion of RCC cells transfected with MEG3 was decreased, whereas knockdown of MEG3 had the opposite effect. The proliferative and metastatic abilities of RCC cells in vivo were concordant with their behavior in vitro. ST3Gal1 expression was dysregulated in RCC and was positively correlated with MEG3. By applying bioinformatics, c-Jun (also known as JUN) was identified as a transcription factor predicted to bind the promoter of ST3Gal1, and altered MEG3 levels resulted in changes to c-Jun expression. Furthermore, ST3Gal1 modulated EGFR sialylation to inhibit EGFR phosphorylation, which affected activation of the phosphoinositide 3-kinase (PI3K)–AKT pathway. Taken together, our findings provide a novel mechanism to elucidate the role of the MEG3–ST3Gal1–EGFR axis in RCC progression.