bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment practices for aspirin‐exacerbated respiratory disease: analysis of a national insurance claims database
Authors: Roland Lauren T. , Nagy Celeste , Wang Heqiong , Moore Renee , Cahill Katherine N. , Laidlaw Tanya M. , Wise Sarah K. , DelGaudio John M. , Kuruvilla Merin , Levy Joshua M. 
Published: November 2019

BackgroundAspirin‐exacerbated respiratory disease (AERD) is the triad of asthma, nasal polyposis, and sensitivity to cyclooxygenase‐1 inhibitors. Treatment options include medical management, surgical intervention, and aspirin desensitization (AsaD).MethodsAERD patients were identified using the MarketScan Database from 2009 to 2015. Patients were included using International Classification of Diseases, 9th edition (ICD‐9) codes for asthma, nasal polyposis, and drug allergy. Treatments were determined by Current Procedural Terminology (CPT) codes for drug desensitization and endonasal procedures. Geographic trends and timing of interventions between those exposed and not exposed to desensitization were explored.ResultsA total of 5628 patients met inclusion criteria for AERD, with mean age 46 years, 60% female; 395 (7%) underwent AsaD and 2171 (39%) underwent sinus surgery. Among patients who were desensitized, 229 (58%) underwent surgery, of whom 201 (88%) had surgery prior to AsaD (median [quartile 1, quartile 3]; 61 days [30, 208] prior to desensitization). For patients undergoing surgery following AsaD (n = 46), surgery was performed a median of 302 (163, 758) days after AsaD. Nineteen patients had multiple surgeries post‐AsaD with median time between surgeries being 734 days (312, 1484); 261 patients were not desensitized to aspirin but did undergo multiple surgeries, with the median of the median time between surgeries being 287 days (15, 617), which is shorter than for patients post‐AsaD (p < 0.001).ConclusionA very small percentage of AERD patients undergo AsaD. Patients who had AsaD underwent surgery approximately 2 months prior to AsaD. Patients who underwent AsaD experienced an increased time between surgeries compared to patients who did not undergo AsaD.
Prescription patterns and opioid usage in sinonasal surgery
Authors: Newberry Christopher I. , Casazza Geoffrey C. , Pruitt Liese C. , Meier Jeremy D. , Skarda David E. , Alt Jeremiah A. 
Published: November 2019

BackgroundExcess opioid use after surgery contributes to opiate misuse and diversion. Understanding opioid prescribing and utilization patterns after sinonasal surgery is critical in designing effective practice protocols. In this study we aim to identify factors associated with variable opioid usage and further delineate optimal prescription patterns for sinonasal surgery.MethodsAll patients undergoing sinonasal surgery within a single health‐care system from March 2017 to August 2018 were sent electronic postoperative surveys. Data were collected on the amount of opioid required, pain control, presurgical opiate use, and narcotic disposal. Additional data collected from the electronic medical record included demographics, type of surgery performed, and total amount of opioid prescribed, including refills.ResultsThree‐hundred sixty four patients were included. A mean number of 25.3 tablets were prescribed per patient, yet the mean taken was just 11.8 tablets. Excess opioids were prescribed 84.9% of the time with a mean excess narcotic in oral morphine equivalents of 152.5. Among patients, 11.8% reported using no opioids, whereas 52.1% used <50% and 36.1% used >50% of their narcotic prescription. Patients used 9.3% of their full prescription and only 2.6% required a refill. The amount used was not associated with complexity of endoscopic sinus surgery, type of opiate prescribed, gender, distance living from hospital, or current opioid usage before surgery (p > 0.05). The addition of septoplasty and/or turbinoplasty was associated with variation in opioid usage (p < 0.001). A total of 76.1% of patients incorrectly discarded/stored excess opiates.ConclusionOpioids are overprescribed after sinonasal surgery. The amount of postoperative opiate prescribed should be greatly reduced and may be based on the specific procedures performed. Improved patient education regarding disposal of excess narcotics may help to curtail future opioid diversion.
Early treatment of progressive vertebral arteriovenous fistula caused by cervical penetrating injury
Authors: Murakami Mamoru , Maruyama Daisuke , Fujiwara Gaku , Komaru Yujiro , Murakami Nobukuni , Iiduka Ryoji 
Published: November 2019

BackgroundPenetrating injury of the vertebral artery (VA) is uncommon because it lies deep in the neck and is surrounded by a bony foramen. Vertebral–venous fistula is a rare vascular condition in which there is direct aberrant communication among the extracranial vertebral artery, its radicular or muscular branches, and adjacent venous structures.Case PresentationWe report an asymptomatic patient of fistula from the vertebral artery to the paravertebral veins secondary to a cervical stab wound that increased in size and flow, as observed on the angiogram 10 days later, which was successfully treated by endovascular surgery. The postoperative angiogram showed improved visualization of the bilateral posterior cerebral arteries.ConclusionEndovascular embolization at the early phase should be undertaken for traumatic high‐flow vertebral–venous fistula, even if the patient is asymptomatic, to prevent progressive posterior circulation insufficiency due to the rapid growth of the fistula, which can ultimately lead to the steal phenomenon.
Dual Illumination Enhances Transformation of an Engineered Green‐to‐Red Photoconvertible Fluorescent Protein
Authors: Krueger Taylor D. , Tang Longteng , Zhu Liangdong , Breen Isabella L. , Wachter Rebekka M. , Fang Chong 
Published: November 2019

AbstractThe molecular mechanisms for the photoconversion of fluorescent proteins remain elusive owing to the challenges of monitoring chromophore structural dynamics during the light‐induced processes. We implemented time‐resolved electronic and stimulated Raman spectroscopies to reveal two hidden species of an engineered ancestral GFP‐like protein LEA, involving semi‐trapped protonated and trapped deprotonated chromophores en route to photoconversion in pH 7.9 buffer. A new dual‐illumination approach was examined, using 400 and 505 nm light simultaneously to achieve faster conversion and higher color contrast. Substitution of UV irradiation with visible light benefits bioimaging, while the spectral benchmark of a trapped chromophore with characteristic ring twisting and bridge‐H bending motions enables rational design of functional proteins. With the improved H‐bonding network and structural motions, the photoexcited chromophore could increase the photoswitching‐aided photoconversion while reducing trapped species.
Structure Selectivity of Alkaline Periodate Oxidation on Lignocellulose for Facile Isolation of Cellulose Nanocrystals
Authors: Liu Peiwen , Pang Bo , Dechert Sebastian , Zhang Xizhou Cecily , Andreas Loren B , Fischer Steffen , Meyer Franc , Zhang Kai 
Published: November 2019

AbstractReported here for the first time is the alkaline periodate oxidation of lignocelluloses for the selective isolation of cellulose nanocrystals (CNCs). With the high concentrations as a potassium salt at pH 10, periodate ions predominantly exist as dimeric orthoperiodate ions (H2I2O104−). With reduced oxidizing activity in alkaline solutions, dimeric orthoperiodate ions preferentially oxidized non‐ordered cellulose regions. The alkaline surroundings promoted the degradation of these oxidized cellulose chains by β‐alkoxy fragmentation and generated CNCs. The obtained CNCs were uniform in size and generally contained carboxy groups. Furthermore, the reaction solution could be reused after regeneration of the periodate with ozone gas. This method allows direct production of CNCs from diverse sources, in particular lignocellulosic raw materials including sawdust (European beech and Scots pine), flax, and kenaf, in addition to microcrystalline cellulose and pulp.
Novel green synthesis of Hibiscus sabdariffa flower extract conjugated gold nanoparticles with excellent anti‐acute myeloid leukemia effect in comparison to daunorubicin in a leukemic rodent model
Authors: Zangeneh Mohammad Mahdi , Zangeneh Akram 
Published: November 2019

Nanobiotechnology is a capable technology that deals with nanomaterials in several scientific domains such as medicine, chemistry, nanotechnology, and biotechnology. In this scale, remarkable differences are seen in many properties of materials that are not observed on a larger scale. In this regard, pharmacologists have tried to synthesize many supplements and drugs from the nanoparticles. The present study confirms the ability of aqueous extract of Hibiscus sabdariffa grown under in vitro condition for the biosynthesis of gold nanoparticles (AuNPs). Also, in this study, we revealed the anti‐acute myeloid leukemia activity of AuNPs compared to daunorubicin in a leukemic rodent model. These nanoparticles were characterized by fourier‐transform infrared spectroscopy (FT‐IR) spectroscopy, ultraviolet–visible spectroscopy (UV–Vis.), X‐ray diffraction (XRD), field emission scanning electron microscopy (FE‐SEM), and transmission electron microscopy (TEM) analysis. TEM and FE‐SEM images exhibited a uniform spherical morphology and diameters of 15‐45 nm for the biosynthesized nanoparticles. In vivo design, induction of acute myeloid leukemia was done by 7,12‐Dimethylbenz[a]anthracene (DMBA) in 75 mice. Then, the animals were randomly divided into six subgroups, including HAuCl4, H. sabdariffa, AuNPs, daunorubicin, untreated, and control. AuNPs similar to daunorubicin, significantly (P ≤ .05) reduced the pro‐inflammatory cytokines (IL1, IL6, IL12, IL18, IFNY, and TNFα), and the total white blood cell (WBC), blast, monocyte, neutrophil, eosinophil, and basophil counts and enhanced the anti‐inflammatory cytokines (IL4, IL5, IL10, IL13, and IFNα) and the platelet, lymphocyte, and red blood cell (RBC) parameters as compared to the untreated mice. By quantitative real‐time polymerase chain reaction, sphingosine‐1‐phosphate receptor‐1 and sphingosine‐1‐phosphate receptor‐5 mRNA expression in lymphocytes were significantly (P ≤ .05) raised by treating the leukemic mice with the AuNPs and daunorubicin. In vitro design, 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) test revealed similar antioxidant potentials for daunorubicin and AuNPs. Besides, AuNPs similar to daunorubicin had low cell viability dose‐dependently against Murine C1498, Human HL‐60/vcr, and 32D‐FLT3‐ITD cell lines without any cytotoxicity on HUVEC cell line. In conclusion, the results of chemical characterization confirm that the H. sabdariffa flower can be used to produce gold nanoparticles with a remarkable amount of anti‐acute myeloid leukemia effect.
Diglyceride production via noncatalyzed esterification of glycerol and oleic acid
Authors: Ting Racquel Ranchie , Agapay Ramelito , Angkawijaya Artik Elisa , Tran Nguyen Phuong Lan , Truong Chi Thanh , Ju Yi‐Hsu 
Published: November 2019

AbstractProduction of diglycerides (DG) plays an important role in food, pharmaceutical, and cosmetic industries. In this study, optimal conditions for DG synthesis via noncatalyzed esterification of oleic acid with glycerol were determined. The temperatures (150°C, 175°C, and 200°C), oleic acid to glycerol molar ratios (1:1, 2:1, 3:1, and 4:1), and initial water content were varied to determine DG selectivity and % conversion over an 8‐hr period in a nitrogen‐purged system. The results exhibited a similar trend to catalyzed studies wherein an increase in temperature and molar ratio leaned towards the production of triglycerides (TG). It was also noted that tested initial water contents had an insignificant effect on reaction rates and product selectivity. Addition of molecular sieves for removal of water also resulted in negligible effects within this temperature range. DG production is optimum at 175°C and 2:1 molar ratio at 4 hr resulting in a product containing 42.6 ± 0.92 wt.% DG and a process selectivity of 1.11 ± 0.06 g DG/g (monoglycerides + TG). Purification by silica gel column chromatography of the product with the highest selectivity resulted in an enriched mixture with a yield of 58.25% and purity of 86.95 wt.% DG. Compared with catalyzed reactions, this system would require less downstream processing as removal of catalysts is not required and saponification does not occur. Although this procedure involves higher reaction temperature compared with enzyme‐catalyzed reactions, the time required to obtain high conversion is much shorter.
Phosphor powders‐incorporated polylactic acid polymeric composite used as 3D printing filaments with green luminescence properties
Authors: Wan Meiling , Jiang Xiao , Nie Jianliang , Cao Qingyun , Zheng Wenxu , Dong Xianming , Fan Z. Hugh , Zhou Wuyi 
Published: November 2019

ABSTRACTA new class of multifunctional nanocomposites holds strong potential in three‐dimensional (3D) printing. In this study, SrAl2O4:Eu2+,Dy3+ powders with fluorescence property were modified with SiO2 to improve its dispersibility and compatibility in the polylactic acid (PLA) matrix. The composite filaments with a diameter of 1.75 ± 0.05 mm containing 2 wt % of modified particles were prepared by a melt blending method. The fluorescent analysis reveals that the composite filaments can be excited by light with a broad band of wavelength from 345 to 455 nm with the highest excitation intensity at 426 nm and have a major emission peak at 487 nm. The morphological analysis and mechanical performance testing on the printed samples showed that modified particles were uniformly dispersed within the PLA matrix and improved the mechanical properties of the composite filaments. Moreover, the modified particles improved hydrophobic behavior and antibacterial properties in comparison with unmodified composite. Therefore, the composite material will have potential applications such as making prototypes for customized furniture and accessories by 3D printing technology. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48644.
Dual responsive wool fabric by cellulose nanowhisker reinforced shape memory polyurethane
Authors: Korkmaz Memiş Nazife , Kaplan Sibel 
Published: November 2019

ABSTRACTShape memory wool fabrics having both temperature and moisture responsiveness were fabricated by a functional nanocomposite treatment comprising of shape memory polyurethane (SMPU) and cellulose nanowhisker (CNW). Water vapor permeability and sweat absorption properties were investigated under different temperature or relative humidity values to test smart comfort capabilities of the treated fabrics. Besides, felting shrinkage and weight loss of the fabrics after repeated washing cycles were investigated for end use performance. It was found out that the wool fabrics functionalized by nanocomposite treatments exhibited dynamic breathability and sweat absorption changing with temperature and relative humidity of body or environment. Moreover, nanocomposite application enhanced rigidity, tear strength, anti‐felting and weight loss performances of the wool fabric. 20 wt% CNW concentration can be suggested for thermal comfort, mechanical and end use performance enhancements to obtain smart garments having dynamic responsiveness to both body physiological and environmental changes. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 137, 48674.
“Inverted” Deep Eutectic Solvents Based on Host‐Guest Interactions
Authors: Yu Dongkun , Mou Hongyu , Fu Hui , Lan Xue , Wang Yingxiong , Mu Tiancheng 
Published: November 2019

AbstractHerein, the concept of “inverted” (the mode “molecules mainly interact with cations”) deep eutectic solvents (DESs) is proposed. A strategy to form inverted DESs by host‐guest interactions was developed, and thus numerous DESs could be designed and formed by a combination of host and guest molecules. These liquids are expected to be used as nonaqueous electrolytes in potassium‐ion batteries or other fields for further exploration.
Close Encounters of the Viral Kind: Cross‐Kingdom Synergies at the Host–Pathogen Interface
Authors: Rowe Hannah M. , Rosch Jason W. 
Published: November 2019

AbstractThe synergies between viral and bacterial infections are well established. Most studies have been focused on the indirect mechanisms underlying this phenomenon, including immune modulation and alterations to the mucosal structures that promote pathogen outgrowth. A growing body of evidence implicates direct binding of virus to bacterial surfaces being an additional mechanism of synergy at the host–pathogen interface. These cross‐kingdom interactions enhance bacterial and viral adhesion and can alter tissue tropism. These bacterial–viral complexes play unique roles in pathogenesis and can alter virulence potential. The bacterial–viral complexes may also play important roles in pathogen transmission. Additionally, the complexes are recognized by the host immune system in a distinct manner, thus presenting novel routes for vaccine development. These synergies are active for multiple species in both the respiratory and gastrointestinal tract, indicating that direct interactions between bacteria and virus to modulate host interactions are used by a diverse array of species.
Evaluating the influence of time of day on activity engagement in persons with dementia
Authors: Boyden Darienne E. , Miltenberger Raymond G. , Novotny Marissa A. 
Published: November 2019

AbstractDementia is a serious disease affecting a growing number of people. With the onset of dementia comes a decline in social activity engagement that can negatively impact multiple aspects of a person's life. Research suggests that time of day may influence a person with dementia's behavior, including activity engagement, but such research is limited. The purpose of this study was to evaluate the influence of time of day on engagement in activities in persons diagnosed with dementia. An alternating treatments design was used with three participants to measure activity engagement during two times of day, morning and afternoon, and during two activities, a moderately preferred and a low preferred. Results showed no differentiation in engagement between morning and afternoon activities for all three participants, with high levels of engagement during both times of day. For two participants, results showed no differentiation in engagement between moderately preferred and low preferred activities. For one participant, levels of engagement were higher during moderately preferred activities than during low preferred activities.
Human elastin‐like polypeptides as a versatile platform for exploitation of ultrasensitive bilirubin detection by UnaG
Authors: Bandiera Antonella , Corich Lucia , Tommasi Silvia , De Bortoli Marco , Pelizzo Paola , Stebel Marco , Paladin Dino , Passamonti Sabina 
Published: November 2019

AbstractA new, bifunctional recombinant protein was expressed as the fusion product of human elastin‐like polypeptide (HELP) and the bilirubin‐binding protein UnaG. The engineered product displays both the HELP‐specific property of forming a functional hydrogel matrix and the UnaG‐specific capacity of emitting green fluorescence upon ligand binding. The new fusion protein has been proven to be effective at detecting bilirubin in complex environments with high background noise. A cell culture model of the stress response, consisting of bilirubin released in the cell culture medium, was set up to assess the bilirubin‐sensing properties of the functional matrix obtained by cross‐linking the HELP moiety. Our engineered protein allowed us to monitor cell induction by the release of bilirubin in the culture medium on a nanomolar scale. This study shows that elastin‐like protein fusion represents a versatile platform for the development of novel and commercially viable analytical and biosensing devices.
Gelatin interpenetration in poly N‐isopropylacrylamide network reduces the compressive modulus of the scaffold: A property employed to mimic hepatic matrix stiffness
Authors: Sarkar Joyita , Kamble Swapnil C. , Patil Rajendra , Kumar Ashok , Gosavi Suresh W. 
Published: November 2019

AbstractThe progression of liver disease from normal to cirrhotic state is characterized by modulation of the stiffness of the extracellular matrix (ECM). Mimicking this modulation in vitro scaffold could provide a better insight into hepatic cell behavior. In this study, interpenetrating poly(N‐isopropylacrylamide‐co‐gelatin) cryogels were synthesized in 48 different compositions to yield scaffolds of different properties. It was observed that a high concentration of N‐isopropylacrylamide (NIPAAm) leads to the formation of small pores while gelatin interpenetration on poly‐NIPAAm framework renders porous structure. Swelling properties and porosity of the gels decreased with an increase in NIPAAm concentration owing to the increased compactness of the gels. Gelatin interpenetration relaxed the gels and enhanced these properties. An increase in gelatin concentration led to a reduction in compressive moduli indicating that gelatin interpenetration in the poly‐NIPAAm network softens the cryogel. With the increase in NIPAAm concentration, the effect of gelatin interpenetration in reducing the compressive moduli expanded. The cytocompatibility studies indicated that the gels are cell‐adherent and compatible with HepG2. Furthermore, biochemical and real‐time polymerase chain reaction studies revealed that HepG2 and Huh‐7 cells cultured on scaffolds mimicking the ECM stiffness of normal liver (1.5–2.5 kPa) exhibited optimum liver‐specific functionalities. Increasing the stiffness to fibrotic (4–9 kPa) and cirrhotic (10–20 kPa) ECM decreases the functionality.
A review of the bioanalytical methods for the quantitative determination of capecitabine and its metabolites in biological matrices
Authors: Knikman Jonathan E. , Rosing Hilde , Guchelaar Henk‐Jan , Cats A. , Beijnen Jos H. 
Published: November 2019

AbstractThe bioanalysis of the oral anticancer drug capecitabine and its metabolites has been investigated extensively over the past years. This paper reviews methods for the bioanalysis of capecitabine and its metabolites. The focus of this review will be on sample pre‐treatment, chromatography and detection. Furthermore, the choice of standards and analytical problems encountered during analysis of capecitabine and its metabolites in biological matrices will be discussed. The major challenges in the bioanalysis of capecitabine and its metabolites are the simultaneous extraction and analysis due to the differences in polarity of the analytes. Furthermore we evaluate currently described methods for the quantification of capecitabine and its metabolites. Future wishes and perspectives are stated that could serve as an inspiration for further development of assays for the quantification of capecitabine and its metabolites.