bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impression space model for the evaluation of Internet advertising effectiveness
Authors: Song Yongqiang , Wang Hong , Zhang Changyong , Wang Lutong 
Published: March 2020

SummaryThe evaluation of Internet advertising effectiveness plays an important role in network marketing at this stage. The evaluation criteria of Internet advertising effectiveness mostly use proceeds as an indicator, ignoring the brand effect generated by Internet advertising, making it difficult for researchers to further study the effect of Internet advertising. With the updating and iteration of technical theory, it is an urgent task to find a new criteria to measure Internet advertising effectiveness. At present, the research on Internet advertising effectiveness research is based on the analysis of nondifferentiation category. The research on user click behavior is a holistic analysis of the whole web page. This global coverage research is difficult to present the behavior characteristics of users in the web page. In response to the above problems, the impression space is proposed to measure Internet advertising effectiveness. Firstly, the fuzzy classification theory is used to digitize the user category data, the user type is divided by probability distribution, and the distribution of web page interest regions is divided by gaze time and page layout to further study the click‐and‐effect relationship of different users and the user browsing time series.Then, establish multimodal multifactors to build an impression space model to measure Internet advertising effectiveness. The experimental results show that the accuracy of the constructed impression space model for the evaluation of Internet advertising effectiveness reaches 92.4%, and the impression space is more effective as the evaluation of Internet advertising effectiveness.
Load‐balanced data gathering in Internet of Things using an energy‐aware cuckoo‐search algorithm
Authors: Sadeghi Fahimeh , Avokh Avid 
Published: March 2020

SummaryThis paper deals with the lifetime problem in the Internet of Things. We first propose an efficient cluster‐based scheme named “Cuckoo‐search Clustering with Two‐hop Routing Tree (CC‐TRT)” to develop a two‐hop load‐balanced data aggregation routing tree in the network. CC‐TRT uses a modified energy‐aware cuckoo‐search algorithm to fairly select the best cluster head (CH) for each cluster. The applied cuckoo‐search algorithm makes the CH role to rotate between different sensors round by round. Subsequently, we extend the CC‐TRT scheme to present two methods for constructing multi‐hop data aggregation routing trees, named “Cuckoo‐search Clustering with Multi‐Hop Routing Tree (CC‐MRT)” and “Cuckoo‐search Clustering with Weighted Multi‐hop Routing Tree (CC‐WMRT).” Both CC‐MRT and CC‐WMRT rely on a two‐level structure; they not only use an energy‐aware cuckoo‐search algorithm to fairly select the best CHs but also adopt a load‐balanced high‐level routing tree to route the aggregated data of CHs to the sink node. However, CC‐WMRT slightly has a better performance thanks to its low‐level routing strategy. As an advantage, the proposed schemes balance the energy consumption among different sensors. Numerical results show the efficiency of the CC‐TRT, CC‐MRT, and CC‐WMRT algorithms in terms of the number of transmissions, remaining energy, energy consumption variance, and network lifetime.
Bacterial vaginosis, representation of endocervical and/or metaplastic cells, and cytological abnormalities in different age groups: Association study
Authors: dos Passos Eva Nayssa , Ribeiro Andrea A. , Tavares Suelene Brito do Nascimento , de Souza Nadja Lindany Alves , Batista Maria de Lourdes Siqueira , Cardoso Filho Leonardo Izidório , de Aquino Érika Carvalho , Rabelo‐Santos Sílvia Helena 
Published: March 2020

AbstractBackgroundStudies have indicated that bacterial vaginosis (BV) might be a cofactor for the acquisition and persistence of high‐risk papillomavirus, enabling the development of cytological abnormalities. The presence of endocervical and metaplastic cells makes the smear more adequate for the detection of these abnormalities once these cell types are representative of the transformation zone, a site of increased susceptibility to viral infection.MethodsThe purpose of this study was to evaluate the patterns of vaginal microbiota, the representation of endocervical and/or metaplastic cells, and the detection of cytological abnormalities in cervical smears from women 15 to 64 years old. Results from satisfactory cytological smears performed in a laboratory school from the Federal University of Goiás were analyzed. The degree of association between the categorical variables was evaluated by the χ2 test, Fisher's Exact test, and stratified analysis through the estimation of the prevalence ratio, with 95% confidence intervals and 5% statistical significance level (P < .05).ResultsThe global prevalence of BV and cytological abnormalities was 22.02% and 8.21%, respectively. BV and the representation of endocervical and/or metaplastic cells were independently associated with the detection of high‐grade cytological abnormalities in the cervical smears of women between 25 and 64 years old.ConclusionsBV and representation of endocervical and/or metaplastic cells were independently associated with the detection of high‐grade cytological abnormalities reinforcing the importance of specimen adequacy and microbiota in the cervical microenvironment.
Integrating genetics, biophysical, and demographic insights identifies critical sites for seagrass conservation
Authors: Jahnke Marlene , Moksnes Per‐Olav , Olsen Jeanine L. , Serra Serra Núria , Nilsson Jacobi Martin , Kuusemäe Kadri , Corell Hanna , Jonsson Per R. 
Published: March 2020

AbstractThe eelgrass Zostera marina is an important foundation species of coastal areas in the Northern Hemisphere, but is continuing to decline, despite management actions. The development of new management tools is therefore urgent in order to prioritize limited resources for protecting meadows most vulnerable to local extinctions and identifying most valuable present and historic meadows to protect and restore, respectively. We assessed 377 eelgrass meadows along the complex coastlines of two fjord regions on the Swedish west coast—one is currently healthy and the other is substantially degraded. Shoot dispersal for all meadows was assessed with Lagrangian biophysical modeling (scale: 100–1,000 m) and used for barrier analysis and clustering; a subset (n = 22) was also assessed with population genetic methods (20 microsatellites) including diversity, structure, and network connectivity. Both approaches were in very good agreement, resulting in seven subpopulation groupings or management units (MUs). The MUs correspond to a spatial scale appropriate for coastal management of “waterbodies” used in the European Water Framework Directive. Adding demographic modeling based on the genetic and biophysical data as a third approach, we are able to assess past, present, and future metapopulation dynamics to identify especially vulnerable and valuable meadows. In a further application, we show how the biophysical approach, using eigenvalue perturbation theory (EPT) and distribution records from the 1980s, can be used to identify lost meadows where restoration would best benefit the present metapopulation. The combination of methods, presented here as a toolbox, allows the assessment of different temporal and spatial scales at the same time, as well as ranking of specific meadows according to key genetic, demographic and ecological metrics. It could be applied to any species or region, and we exemplify its versatility as a management guide for eelgrass along the Swedish west coast.
Identification and population genetic comparison of three ascidian species based on mtDNA sequences
Authors: Bhattachan Punit , Qiao Runyu , Dong Bo 
Published: March 2020

AbstractAscidians are sessile marine chordate invertebrates found along seashores worldwide and are typically regarded as invasive organisms. Knowledge concerning their global genetic structure and subsequent invasive potential is limited. Here, we identified three ascidians—Ciona robusta, Ciona savignyi, and Styela clava from the northeast region of China using morphological characteristics and mitochondrial cytochrome c oxidase subunit I (cox1) as genetic marker. We additionally used phylogenetics to aid in the identification of these three species. The results of a population genetic analysis showed that among the three species, the level of haplotype diversity was particularly high within C. savignyi, and nucleotide diversity varied moderately. We divided the three species separately into native and invasive populations using 170 cox1 sequences from global resources to explore population genetic structure and invasive potential. Although in the network analysis Ciona spp. formed haplogroups of native and invasive populations, some haplotypes were still shared. We found that the haplotypes did not cluster within the network of S. clava. Our AMOVA results also showed that Ciona spp. had a weak genetic structure, and less genetic differentiation was present in S. clava. These data suggest that there are extensive incursions of these three ascidians into different geographical regions. Global comparisons of ascidian populations will help in the understanding of their population genetic structure and invasive potential, hence providing important insights regarding conservation as well as management.
Acute correction of electromechanical dyssynchrony and response to cardiac resynchronization therapy
Authors: Moubarak Ghassan , Viart Guillaume , Anselme Frédéric 
Published: March 2020

AbstractAimsEchocardiographic measures of dyssynchrony at baseline have not demonstrated a good ability to predict response to cardiac resynchronization therapy (CRT). The purpose of this study was to determine if the acute correction of electromechanical dyssynchrony, assessed by the change in simple pulsed‐Doppler measures, was related to CRT response at 6 months.Methods and resultsEchocardiography was performed at baseline and at pre‐discharge after CRT implantation. Intraventricular, interventricular, and atrioventricular dyssynchrony were evaluated by the left pre‐ejection interval (LPEI), the interventricular mechanical delay, and the ratio of left ventricular filling time to RR interval, respectivelxy. A patient was considered responder if he/she was alive without hospitalization for heart failure and had an absolute increase of left ventricular ejection fraction (LVEF) >5 points. Forty‐eight patients (mean age 67 ± 11 years, 73% male, mean LVEF 30 ± 5%) were included. CRT led to an acute correction of intraventricular and interventricular dyssynchrony but not to an acute correction of atrioventricular dyssynchrony. There were 31 (65%) responders at 6 months. Two factors were independently associated with CRT response in multivariate analysis: ischemic cardiomyopathy (odds ratio 0.19, 95% confidence interval 0.04–0.87; P= 0.032) and delta LPEI (odds ratio 1.03 per 1 ms decrease, 95% confidence interval 1.01–1.05; P = 0.007). By receiver operating characteristic analysis, the optimal cut‐off value of delta LPEI was −16 ms. The proportion of responders in patients without ischemic cardiomyopathy and with a delta LPEI greater than −16 ms was 85%.ConclusionsAcute correction of intraventricular electromechanical dyssynchrony evaluated by the LPEI predicted CRT response at 6 months.
Outpatient treatment of worsening heart failure with intravenous and subcutaneous diuretics: a systematic review of the literature
Authors: Wierda Eric , Dickhoff Cathelijne , Handoko Martin Louis , Oosterom Liane , Kok Wouter Emmanuel , de Rover Y. , de Mol B.A.J.M. , van Heerebeek Loek , Schroeder‐Tanka Jutta Maria 
Published: March 2020

AbstractAimsIn the coming decade, heart failure (HF) represents a major global healthcare challenge due to an ageing population and rising prevalence combined with scarcity of medical resources and increasing healthcare costs. A transitional care strategy within the period of clinical worsening of HF before hospitalization may offer a solution to prevent hospitalization. The outpatient treatment of worsening HF with intravenous or subcutaneous diuretics as an alternative strategy for hospitalization has been described in the literature.Methods and resultsIn this systematic review, the available evidence for the efficacy and safety of outpatient treatment with intravenous or subcutaneous diuretics of patients with worsening HF is analysed. A search was performed in the electronic databases MEDLINE and EMBASE. Of the 11 included studies 10 were single‐centre, using non‐randomized, observational registries of treatment with intravenous or subcutaneous diuretics for patients with worsening HF with highly variable selection criteria, baseline characteristics, and treatment design. One study was a randomized study comparing subcutaneous furosemide with intravenous furosemide. In a total of 984 unique individual patients treated in the reviewed studies, only a few adverse events were reported. Re‐hospitalization rates for HF at 30 and 180 days were 28 and 46%, respectively. All‐cause re‐hospitalization rates at 30 and 60 days were 18–37 and 22%, respectively. The highest HF re‐hospitalization was 52% in 30 days in the subcutaneous diuretic group and 42% in 30 days in the intravenous diuretic group.ConclusionsThe reviewed studies present practice‐based results of treatment of patients with worsening HF with intravenous or subcutaneous diuretics in an outpatient HF care unit and report that it is effective by relieving symptoms with a low risk of adverse events. The studies do not provide satisfactory evidence for reduction in rates of re‐hospitalization or improvement in mortality or quality of life. The conclusions drawn from these studies are limited by the quality of the individual studies. Prospective randomized studies are needed to determine the safety and effectiveness of outpatient intravenous or subcutaneous diuretic treatment for patient with worsening HF.
Dynamic simulation and assessment of the ecological benefits of hydropower as an alternative energy for thermal power under ecological civilization construction: A case study of Fujian, China
Authors: Zhang Lihui , Chai Jianxue , Zhu Jinrong , Zhao Zhenli 
Published: March 2020

AbstractAs ecological civilization construction receives growing attention in China, the eco‐friendliness of the power supply structure is becoming increasingly important. Thermal power and hydropower are the two major power sources in China. Hydropower has both positive and negative effects on the ecosystem. However, there are few studies on the comprehensive impact of hydropower on the ecosystem. Therefore, the main innovation of this article is to integrally and comprehensively study the impact of hydropower to propose recommendations for hydropower development. The study of hydropower's effects on the overall ecosystem including resources, the environment, and economic society reflects the integrity, and the simultaneous study of hydropower's positive and negative effects reflects the comprehensiveness. First, this paper constructs a system dynamics (SD) model that can analyze the impact of replacing thermal power with hydropower on the ecosystem and proposes an improved coupling coordination degree (CCD) model. Then, this paper takes the province of Fujian as an example for SD scenario simulation and proposes recommendations for each indicator in the ecology subsystem. Finally, this paper performs CCD analysis on subsystems of the ecology subsystem in different policy scenarios and provides suggestions for future hydropower development in Fujian. Results show that hydropower technology improvement and efficiency increase (HTIEI) is more conducive to the development of the overall ecosystem. The scientificity of the current hydropower policy in Fujian is proven through theoretical analysis, and further hydropower development proposals are proposed. This paper provides a basis for the formulation of power generation policies and promotes ecological civilization construction for Fujian. The proposed methods in this paper can also provide tools for policy research on clean energy power generation.
Orthogonal frequency division multiplexing with subcarrier power modulation for doubling the spectral efficiency of 6G and beyond networks
Authors: Hamamreh Jehad M. , Hajar Abdulwahab , Abewa Mohamedou 
Published: March 2020

AbstractWith the emergence of new applications (eg, extended reality [XR] and haptics), which require to be simultaneously served not just with low latency and sufficient reliability, but also with high spectral efficiency, future networks (ie, 6G and beyond) should be capable of meeting this demand by introducing new effective transmission designs. Motivated by this, a novel modulation technique termed as orthogonal frequency division multiplexing with subcarrier power modulation (OFDM‐SPM) is proposed for providing highly spectral‐efficient data transmission with low‐latency and less‐complexity for future 6G wireless communication systems. OFDM‐SPM utilizes the power of subcarriers in OFDM blocks as a third dimension to convey extra information bits while reducing both complexity and latency compared to conventional schemes. In this article, the concept of OFDM‐SPM is introduced and its validity as a future adopted modulation technique is investigated over a wireless multipath Rayleigh fading channel. The proposed system structure is explained, an analytical expression of the bit error rate (BER) is derived, and numerical simulations of BER and throughput performances of OFDM‐SPM are carried out. OFDM‐SPM is found to greatly enhance the spectral efficiency where it is capable of doubling it. In addition, OFDM‐SPM introduces negligible complexity to the system, does not exhibit error propagation, reduces the transmission delay, and decreases the transmission power by
half.
Assessing the potential and safety of Myrtus communis flower essential oils as efficient natural preservatives against Listeria monocytogenes growth in minced beef under refrigeration
Authors: Dhifi Wissal , Jazi Sabrine , El Beyrouthy Marc , Sadaka Carmen , Mnif Wissem 
Published: March 2020

AbstractIn this research, the chemical composition and biological properties of Tunisian Myrtus communis (McEO) flowers were investigated. The antibacterial effect of McEO toward some bacteria was assessed, alone and in combination with nisin. The major components of McEO were α‐pinene, 1,8‐cineol, limonene, and linalool. McEO exhibited cytotoxicity toward HepG2 and MCF‐7 cell lines. The microbiological data showed that Gram‐positive bacteria were more susceptible to McEO. McEO had a bactericidal effect against L. monocytogenes. McEO is able to prevent lipid oxidation, microbial development at noncytotoxic concentrations, when used alone or in combination with nisin. It can improve sensory attributes within acceptable limits and improve the conservation of shelf life of minced beef meat during the 4°C storage period. The most potent preservative effect was obtained with the mixture: 0.8% McEO with 500 IU/g of nisin. This combination may be a good alternative for the development of natural preservatives.
Preliminary investigation on a new natural based poly(gamma‐glutamic acid)/Chitosan bioink
Authors: Pisani Silvia , Dorati Rossella , Scocozza Franca , Mariotti Camilla , Chiesa Enrica , Bruni Giovanna , Genta Ida , Auricchio Ferdinando , Conti Michele , Conti Bice 
Published: March 2020

AbstractThe study aims to investigate a novel bioink made from Chitosan (Cs)/ poly(gamma‐glutamic acid) (Gamma‐PGA) hydrogel that takes advantage of the two biodegradable and biocompatible polymers meeting most of the requirements for biomedical applications. The bioink could be an alternative to other materials commonly used in 3D‐bioprinting such as gelatin or alginate. Cs/ Gamma‐PGA hydrogel was prepared by double extrusion of Gamma‐PGA and Cs solutions, where 2 × 105 human adult fibroblasts per ml Cs solution had been loaded, through Cellink 3D‐Bioprinter at 37°C. A computer aided design model was used to get 3D‐bioprinting of a four layers grid hydrogel construct with 70% infill. Hydrogel characterization involved rheology, FTIR analysis, stability study (mass loss [ML], fluid uptake [FU]), and cell retaining ability into hydrogel. 3D‐bioprinted hydrogel gelation time resulted to be <60 s, hydrogel structure was maintained up to 36.79 Pa shear stress, FTIR analysis demonstrated Gamma‐PGA/Cs interpolyelectrolyte complex formation. The 3D‐bioprinted hydrogel was stable for 35 days (35% ML) in cell culture medium, with increasing FU. Cell loaded 3D‐bioprinted Cs 6% hydrogel was able to retain 70% of cells which survived to printing process and cell viability was maintained during 14 days incubation.
Correlation of sex‐determining region Y‐box 30 with tumor characteristics and its prognostic value in breast cancer
Authors: Peng Hui , Luo Yang , Wu Jing , Yin Wanling 
Published: March 2020

AbstractObjectiveSex‐determining region Y‐box 30 (SOX30) suppresses progression of several cancers, whereas its role in breast cancer is unclear. Therefore, we aimed to determine the correlation of SOX30 with tumor characteristics and prognosis in breast cancer patients.MethodsThe tumor samples of 510 breast cancer patients who underwent resection were obtained, and SOX30 expression was analyzed by immunohistochemistry. Clinical characteristics, disease‐free survival (DFS), and overall survival (OS) of breast cancer patients were recorded.ResultsThere were 368 breast cancer patients in SOX30 low‐expression group and 142 in SOX30 high‐expression group. SOX30 was negatively correlated with tumor size (P = .010), tumor (T) stage (P < .001), node (N) stage (P = .001), and tumor, node, metastasis (TNM) stage (P < .001) in breast cancer patients. For prognosis, patients in SOX30 high‐expression group had prolonged DFS (P = .011) and OS (P = .002); moreover, increased SOX30 grade (assessed by semi‐quantitative scoring method assessment) was correlated with better DFS (P = .015) and OS (P = .014). Univariate Cox's regression analysis disclosed that SOX30 high expression was correlated with enhanced DFS (P = .012, hazard ratio (HR) = 0.582) and OS (P = .002, HR = 0.389); however, multivariate Cox's regression analysis revealed that SOX30 could not independently predict DFS (P = .224, HR = 0.766) or OS (P = .087, HR = 0.582) in breast cancer patients, indicating it might interact with other independent predictive factors (such as pathological differentiation, T stage, and N stage) to influence DFS and OS in breast cancer patients.ConclusionSex‐determining region Y‐box 30 is a potential prognostic biomarker in breast cancer, which might contribute to the better outcome of breast cancer patients.