bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparative analysis of gene expression induced by the embryo in the caprine endometrium
Authors: Liu Xiaorui , Zhang Lei , Han Jincheng , Yang Lichun , Cui Jiuzeng , Che Sicheng , Cao Binyun , Song Yuxuan 
Published: November 2019

AbstractTranscriptomics is an established powerful tool to identify potential mRNAs and ncRNAs (non‐coding RNAs) for endometrial receptivity. In this study, the goat endometrium at estrus day 5 (ED5) and estrus day 15 (ED15) were selected to systematically analyse the differential expressed genes (DEGs) what were induced by the embryo. There were 1,847 genes which were significantly differential expressed in endometrium induced by the embryo at ED5, and 1,346 at ED15 (p‐value < .05). Secreted phosphoprotein 1 (SPP) was the responsive genes for embryo in the goat endometrium during estrus cycle, neurotensis (NTS) and pleiotrophin (PTN) were the responsive genes for embryo in the goat endometrium at ED5, Testin (TES) and Phosphate and Tension Homology Deleted on Chromsome ten (PTEN) at ED15. Furthermore, Gene Ontology (GO) and Kyoto Encyclopedia of Genes (KEGG) analysis revealed cytoplasm and Endocytosis were indispensable for the endometrium development in dairy goat. In a word, this resulting view of the transcriptome greatly uncovered the global trends in mRNAs expression induced by the embryo in the endometrium of dairy goats.
Infestation of small ruminants by the metacestode stage of Taenia hydatigena in slaughterhouse, North East Tunisia
Authors: Khaled Khouloud , Teber Ghaleb , Bouaicha Faten , Amairia Safa , Rekik Mourad , Gharbi Mohamed 
Published: November 2019

AbstractBackgroundCysticercus tenuicollis (larvae of Taenia hydatigena) is a frequent cosmopolitan endoparasite of ruminants. The infestation by this parasite is underestimated since it is neither zoonotic nor inducing high economic losses in the sheep sector.MethodsThis study aimed at estimating different parasitological indicators, Cysticercus tenuicollis infestation in small ruminants using a slaughterhouse‐based survey in Northeast Tunisia. A total number of 3,692 sheep and 78 goats were examined in the slaughterhouse of Menzel Temime.ResultsThe overall prevalence was estimated to be 2.8 (106/3692) and 8.9% (7/78) in sheep and goats, respectively. The abundance in these two species was 0.24 and 0.05 and the intensity 1.97 and 2.85, respectively. In goats, all the cysts were found in the mesentery, whilst, in sheep, the majority were in mesentery (96%) but also on the liver in 2% of the cases and in both organs (2%). There were only cysts with aqueous liquid with predominantly middle‐sized cysts (1 to 3 cm) corresponding to 63.15 and 70.34% in sheep and goats, respectively.ConclusionSince, in small ruminants, the infestation by C. tenuicollis indicators are not high, low cost control measures should be implemented to eliminate this parasite in Northeast Tunisia.
An application of Integrated Water Resource Management principles to flood risk mitigation in Mossman, North Queensland, Australia
Authors: Dinh Giang N. , McIntosh Brian S. 
Published: November 2019

AbstractAs the economic and political center of Douglas Shire in Far North Queensland, Australia, the Mossman Township plays an important role in the development of the region. To allow for the economic and population growth of the town, the local authority has developed strategies to expand the residential and industrial zones closer to the Mossman River. However, these areas are frequently affected by fluvial floods that are exacerbated by the confluence of the two Mossman tributaries, South and North. In addition, the frequency and intensity of floods is likely to increase under the impact of climate change. To minimize flood risk in this area, the State and Local Governments have a coordinated approach to implement measures to address the issue. However, these measures have limitations and it is difficult to achieve all of their intended objectives.To support the Mossman authorities in improving flood resilience, this study combined the principles of Integrated Water Resources Management and Flood Risk Management to identify and assess measures to achieve flood risk mitigation. This study proposes a range of measures that may enable the region to reduce the exposure and vulnerability of the affected population to flood hazard. Subsequently, these measures were evaluated from different perspectives including risk index, financial cost, and the environmental and social impact of each.By using a new methodology for flood risk assessment that considers exposure, vulnerability, and tolerance of the community to flood risk, this study determined that the current flood risk level in Mossman is high. To reduce the high‐risk level to low, three measures were proposed: land use change, the construction of flood levees, and a flood forecasting and warning system. The study found that the implementation of each measure alone does not minimize flood risk effectively, especially within important zones such as residential areas, the town center, and critical roads. It was also found that relying on just one measure impacts the economic, social, or environmental conditions of the study area significantly. The simultaneous implementation of three measures is, therefore, perceived to be necessary. The combination of measures determined by using Integrated Water Resources Management principles enables the region to mitigate flood risk effectively, and also provides an opportunity to balance benefits and cost economically, environmentally, and socially.
Pluralism and Perspectivism in the American Pragmatist Tradition
Authors: Brown Matthew J. 
Published: November 2019

AbstractThis chapter explores perspectivism in the American Pragmatist tradition. On the one hand, the thematization of perspectivism in contemporary epistemology and philosophy of science can benefit from resources in the American Pragmatist philosophical tradition. On the other hand, the Pragmatists have interesting and innovative, pluralistic views that can be illuminated through the lens of perspectivism. I pursue this inquiry primarily through examining relevant sources from the Pragmatist tradition. I will illustrate productive engagements between pragmatism and perspectivism in three areas: in the pragmatists’ fallibilistic theories of inquiry and truth, in their pluralistic metaphysics, and in their views on cultural pluralism. While there are some potential sticking points between pragmatism and perspectivism, particularly around the visual metaphor of perspective, these philosophical approaches nonetheless have much to learn from each other. Perspectivism is in danger of falling between the horns of pernicious relativism and a platitudinous view of the limits of human perception and cognition. The pragmatists accounts of truth and reality open the possibility of a more thoroughgoing perspectivism. I will follow this thread through Charles S. Peirce’s, William James’, and John Dewey’s theories of inquiry and truth, Peirce’s evolutionary metaphysics, James’ radical pluralism, Dewey’s cultural naturalism, Richard Rorty’s anti-essentialism, Jane Addams’ standpoint epistemology, W.E.B. Du Bois’ theory of race consciousness, Horace Kallen’s and Alain LeRoy Locke’s cultural pluralism, and Mary Parker Follett’s account of pluralistic integration.
Perspectives, Questions, and Epistemic Value
Authors: Khalifa Kareem , Millson Jared 
Published: November 2019

AbstractMany epistemologists endorse true-belief monism, the thesis that only true beliefs are of fundamental epistemic value. However, this view faces formidable counterexamples. In response to these challenges, we alter the letter, but not the spirit, of true-belief monism. We dub the resulting view “inquisitive truth monism”, which holds that only true answers to relevant questions are of fundamental epistemic value. Which questions are relevant is a function of an inquirer’s perspective, which is characterized by his/her interests, social role, and background assumptions. Using examples of several different scientific practices, we argue that inquisitive truth monism outperforms true-belief monism.
Perspectivalism About Knowledge and Error
Authors: Treanor Nick 
Published: November 2019

AbstractKnowledge and error have a quantitative dimension – we can know more and less, and we can be wrong to a greater or lesser extent. This fact underpins prominent approaches to epistemic normativity, which we can loosely call truth-consequentialist. These approaches face a significant challenge, however, stemming from the observation that some truths seem more epistemically valuable than others. In this paper I trace out this perspectivalist challenge, showing that although it arises from a mistaken picture of the quantitative dimension of knowledge and error, when we reconceive how that quantitative dimension should be understood we find the perspectivalist challenge has survived unscathed.
Knowledge from a Human Point of View
Authors: Stroud Barry 
Published: November 2019

AbstractEverything that is known by human beings is known from a human point of view. There is no other point of view from which human beings can know anything. Is there something distinctively “perspectival” about human knowledge or the study of human knowledge? Explaining how such-and-such has come to be known by human beings involves explaining how those who know it came to get things right. Those who explain that knowledge are thereby committed to the truth of what is said to be known. Can we explain, from a human point of view, how it has come to be known that such-and-such is so in the world we live in? Or can we explain, from a human point of view, only how it has come to be known that such-and-such is so from a human point of view in the world we live in?
A “P5” Approach to Healthcare and Health Technology
Authors: Pravettoni Gabriella , Triberti Stefano 
Published: November 2019

AbstractThe challenges represented by chronic conditions worldwide are related to disease management and patient engagement. Healthcare should open not only to new tools and resources but also to innovative approaches. This contribution deepens the concept of P5 medicine, namely, an evolution of patient-centered medicine approaches which tries to identify the main characteristics medical interventions should have in order to meet patients’ needs. Specifically, healthcare should be predictive, personalized, preventive, participatory, and psychocognitive. eHealth, or the use of new technologies in healthcare contexts, represents an extraordinary opportunity to achieve all of these features. The second part of this contribution will present brief history of eHealth, its development, the multiple forms it assumes today, and literature on encouraging results and emerging criticalities as well. The present book will feature guidelines and examples of how eHealth could be designed and implemented in order to reach P5 recommendations in healthcare globally.
Psycho-cognitive Factors Orienting eHealth Development and Evaluation
Authors: Gorini Alessandra , Caiani Enrico Gianluca , Pravettoni Gabriella 
Published: November 2019

AbstractThe P5 approach to medicine emphasizes the importance of psychological and cognitive factors in the healthcare process, namely, the enhancement of patients’ responsibility to participate in the medical decision making, patient education, as well as the measurement and support to quality of life. In the context of eHealth development and evaluation, such factors are more and more important to ensure successful implementation. This contribution explores the role of these factors in health technologies, and tools/approaches useful for exploiting psychological factors in eHealth; for example, the concept of “persuasive technology” is explored and updated in the field of health technologies. As the more innovative and groundbreaking of the Ps, the fifth is the one where more space for improvement and advancement could be envisaged in future medicine. The contribution ends with highlighting hints for future studies.
User-Centered Design Approaches and Methods for P5 eHealth
Authors: Triberti Stefano , Brivio Eleonora 
Published: November 2019

AbstractAs seen throughout this book, eHealth informed by P5 approach gives full recognition to patients’ contexts, needs, desires, and personal characteristics. These aspects should not only be considered as cornerstones for technology evaluation, but as fundamental guidelines for design in the first place. This relates to User-Centered Design, that is, any technology/service design where final users influence how the design itself takes place. In other words, eHealth development should be based on research data gathered among final users about their needs and contexts of use, in order to be specifically tailored on final users even before the realization of low-level prototypes. This methodological contribution presents a critical presentation, description, and evaluation of research tools to be employed not to evaluate technology’s results and effectiveness, but the specific characteristics of users in order to orient design and development. Such an approach should be considered the “gold standard” of P5 eHealth solutions.
Ishibashi states, topological orders with boundaries and topological entanglement entropy. Part II. Cutting through the boundary
Authors: Shen Ce , Lou Jiaqi , Hung Ling-Yan 
Published: November 2019

Abstract
We compute the entanglement entropy in a 2+1 dimensional topological order in the presence of gapped boundaries. Specifically, we consider entanglement cuts that cut through the boundaries. We argue that based on general considerations of the bulk- boundary correspondence, the “twisted characters” feature in the Renyi entropy, and the topological entanglement entropy is controlled by a “half-linking number” in direct analogy to the role played by the S-modular matrix in the absence of boundaries. We also construct a class of boundary states based on the half-linking numbers that provides a “closed-string” picture complementing an “open-string” computation of the entanglement entropy. These boundary states do not correspond to diagonal RCFT’s in general. These are illustrated in specific Abelian Chern-Simons theories with appropriate boundary conditions.
What do we know about the influence of vacuum on bacterial biocenosis used in environmental biotechnologies?
Authors: Gnida Anna 
Published: November 2019

AbstractThe article aims to show the increased interest in the applications of vacuum in the area of environmental biotechnology and the lack of research related to the effects of vacuum on bacteria and microbial communities. Information on the impact of vacuum on bacteria is limited and often comes from unrelated research fields. In most cases (astrobiology research, food preservation technologies), the exposure of microorganisms in vacuum is permanent for the whole life of a cell. In environmental science applications, the exposure of microorganisms containing media such as sludge or soil in vacuum is rather persistent, and lower values of vacuum are used. Vacuum is used or proposed to be used in wastewater treatment, anaerobic digestion, sludge treatment, soil remediation and mining. Usually, vacuum is used to remove gases from the test medium, so a purely physical process is applied. However, most reports show the influence of vacuum on biological processes and its efficiency, as well as on the community structure.
Assessing multiple predator, diurnal and search area effects on predatory impacts by ephemeral wetland specialist copepods
Authors: Cuthbert Ross N. , Dalu Tatenda , Wasserman Ryan J. , Monaco Cristián J. , Callaghan Amanda , Weyl Olaf L. F. , Dick Jaimie T. A. 
Published: November 2019

AbstractPredator–prey interaction strengths can be highly context-dependent. In particular, multiple predator effects (MPEs), variations in predator sex and physical habitat characteristics may affect prey consumption rates and thus the persistence of lower trophic groups. Ephemeral wetlands are transient ecosystems in which predatory copepods can be numerically dominant. We examine the interaction strengths of a specialist copepodParadiaptomus lamellatustowards mosquito prey in the presence of conspecifics using a functional response approach. Further, we examine sex variability in predation rates ofP. lamellatusunder circadian and surface area variations. Then, we assess the influence of a co-occurring heterospecific predatory copepod,Lovenula raynerae, on total predation rates. We demonstrate MPEs on consumption, with antagonism between conspecificP. lamellatuspredatory units evident, irrespective of prey density. Furthermore, we show differences between sexes in interaction strengths, with femaleP. lamellatussignificantly more voracious than males, irrespective of time of day and experimental arena surface area. Predation rates byP. lamellatuswere significantly lower than the heterospecific calanoid copepodL. raynerae, whilst heterospecific copepod groups exhibited the greatest predatory impact. Our results provide insights into the predation dynamics by specialist copepods, wherein species density, diversity and sex affect interaction strengths. In turn, this may influence population-level persistence of lower trophic groups under shifting copepod predator composition.
The Association of Women’s Empowerment with Stillbirths in Nepal
Authors: Gurung Abhishek , Bajracharya Kiran , Gurung Rejina , Budhathoki Shyam Sundar , KC Naresh Pratap , Shrestha Parashu Ram , KC Ashish 
Published: November 2019

Abstract
Introduction
Globally, 2.6 million stillbirths occur each year. Empowering women can improve their overall reproductive health and help reduce stillbirths. Women empowerment has been defined as women’s ability to make choices in economic decision-making, household and health care decision-making. In this paper, we aimed to evaluate if women’s empowerment is associated with stillbirths.

Methods
Data from 2016 Nepal Demographic Health Surveys (NDHS) were analysed to evaluate the association between women’s empowerment and stillbirths. Equiplots were generated to assess the distribution of stillbirths by wealth quintile, place of residence and level of maternal education using data from NHDS 1996, 2001, 2006, 2011 and 2016 data. For the association of women empowerment factors and stillbirths, univariate and multivariate analyses were conducted.

Results
A total of 88 stillbirths were reported during the survey. Univariate analysis showed age of mother, education of mother, age of husband, wealth index, head of household, decision on healthcare and decision on household purchases had significant association with stillbirths (p < 0.05). In multivariate analysis, only maternal age 35 years and above was significant (aOR 2.42; 1.22–4.80). Education of mother (aOR 1.48; 0.94–2.33), age of husband (aOR 1.54; 0.86–2.76), household head (aOR 1.51; 0.88–2.59), poor wealth index (aOR 1.62; 0.98–2.68), middle wealth index (aOR 1.37; 0.76–2.47), decision making for healthcare (aOR 1.36; 0.84–2.21) and household purchases (aOR 1.01; 0.61–1.66) had no any significant association with stillbirths.

Conclusions
There are various factors linked with stillbirths. It is important to track stillbirths to improve health outcomes of mothers and newborn. Further studies are necessary to analyse women empowerment factors to understand the linkages between empowerment and stillbirths.
Safety and efficacy of stenting for aortic arch hypoplasia in patients with coarctation of the aorta
Authors: Warmerdam E. G. , Krings G. J. , Meijs T. A. , Franken A. C. , Driesen B. W. , Sieswerda G. T. , Meijboom F. J. , Doevendans P. A. F. , Molenschot M. M. C. , Voskuil M. 
Published: November 2019

AbstractBackgroundDespite a successful repair procedure for coarctation of the aorta (CoA), up to two-thirds of patients remain hypertensive. CoA is often seen in combination with abnormal aortic arch anatomy and morphology. This might be a substrate for persistent hypertension. Therefore, we performed endovascular aortic arch stent placement in patients with CoA and concomitant aortic arch hypoplasia or gothic arch morphology. The goal of this retrospective analysis was to investigate the safety and efficacy of aortic arch stenting.MethodsA retrospective analysis was performed in patients who underwent stenting of the aortic arch at the University Medical Center Utrecht. Measurements collected included office blood pressure, use of antihypertensive medication, invasive peak-to-peak systolic pressure over the arch, and aortic diameters on three-dimensional angiography. Data on follow-up were obtained at the date of most recent outpatient visit.ResultsTwelve patients underwent stenting of the aortic arch. Mean follow-up duration was 14 ± 11 months. Mean peak-to-peak gradient across the arch decreased from 39 ± 13 mm Hg to 7 ± 8 mm Hg directly after stenting (p < 0.001). There were no major procedural complications. Mean systolic blood pressure decreased from 145 ± 16 mm Hg at baseline to 128 ± 9 mm Hg at latest follow-up (p = 0.014).ConclusionThis retrospective study shows that stenting of the aortic arch is successful when carried out in a state-of-the-art manner. A direct optimal angiographic and haemodynamic result was shown. No major complications occurred during or after the procedure. At short- to medium-term follow-up a decrease in mean systolic blood pressure was observed.
Technology in the Age of Innovation: Responsible Innovation as a New Subdomain Within the Philosophy of Technology
Authors: von Schomberg Lucien , Blok Vincent 
Published: November 2019

AbstractPraised as a panacea for resolving all societal issues, and self-evidently presupposed as technological innovation, the concept of innovation has become the emblem of our age. This is especially reflected in the context of the European Union, where it is considered to play a central role in both strengthening the economy and confronting the current environmental crisis. The pressing question is how technological innovation can be steered into the right direction. To this end, recent frameworks of Responsible Innovation (RI) focus on how to enable outcomes of innovation processes to become societally desirable and ethically acceptable. However, questions with regard to the technological nature of these innovation processes are rarely raised. For this reason, this paper raises the following research question:To what extent is RI possible in the current age, where the concept of innovation is predominantly presupposed as technological innovation?On the one hand, we depart from a post-phenomenological perspective to evaluate the possibility of RI in relation to the particular technological innovations discussed in the RI literature. On the other hand, we emphasize the central role innovation plays in the current age, and suggest that the presupposed concept of innovation projects a techno-economic paradigm. In doing so, we ultimately argue that in the attempt to steer innovation, frameworks of RI are in fact steered by the techno-economic paradigm inherent in the presupposed concept of innovation. Finally, we account for what implications this has for the societal purpose of RI.
Diagnosis and Management of Pulmonary Hypertension in the Modern Era: Insights from the 6th World Symposium
Authors: Thomas Christopher A. , Anderson Ryan J. , Condon David F. , de Jesus Perez Vinicio A. 
Published: November 2019

AbstractThe past 20 years have seen major advances in the diagnosis and management of pulmonary hypertension, a disease associated with significant morbidity and mortality. The 6th World Symposium in Pulmonary Hypertension (WSPH) took place in February 2018 and attempted to consolidate the current knowledge in the field into practical recommendations to help prioritize an action plan to improve patient outcomes and identify future research directions. In this review, we will summarize the highlights of the 6th WSPH proceedings, including revisions to the hemodynamic definitions and classification of the various types of pulmonary hypertension, genetic advances, approaches to risk stratification, and updated treatment algorithms.