bluuebunny/crossref_metadata_2025_split huggingface dataset:
Food‐induced anaphylaxis in infancy compared to preschool age: A retrospective analysis
Authors: Pouessel Guillaume , Jean‐Bart Charlotte , Deschildre Antoine , Van der Brempt Xavier , Tanno Luciana Kase , Beaumont Pascale , Dumond Pascale , Sabouraud‐Leclerc Dominique , Beaudouin Etienne , Ramdane Nassima , Liabeuf Valérie , Renaudin Jean‐Marie ,   on behalf of the Allergy Vigilance Network
Published: October 2019

AbstractObjectiveLittle is known regarding food anaphylaxis in infancy. We aimed to describe specificities of food anaphylaxis in infants (≤12 months) as compared to preschool children (1‐6 years).MethodsWe conducted a retrospective study of all food anaphylaxis cases recorded by the Allergy Vigilance Network from 2002 to 2018, in preschool children focusing on infants.ResultsOf 1951 food anaphylaxis reactions, 61 (3%) occurred in infants and 386 (20%) in preschool children. Two infants had two anaphylaxis reactions; thus, we analyzed data among 59 infants (male: 51%; mean age: 6 months [SD: 2.9]); 31% had a history of atopic dermatitis, 11% of previous food allergy. The main food allergens were cow's milk (59%), hen's egg (20%), wheat (7%) and peanut (3%) in infants as compared with peanut (27%) and cashew (23%) in preschool children. Anaphylaxis occurred in 28/61 (46%) cases at the first cow's milk intake after breastfeeding discontinuation. Clinical manifestations were mainly mucocutaneous (79%), gastrointestinal (49%), respiratory (48%) and cardiovascular (21%); 25% of infants received adrenaline. Hives, hypotension and neurologic symptoms were more likely to be reported in infants than in preschool children (P = .02; P = .004; P = .002, respectively). Antihistamines and corticosteroids were more often prescribed in preschool children than in infants (P = .005; P = .025, respectively).ConclusionOur study found that in infants presenting with their first food allergy, in a setting with a high rate of infant formula use, the most predominant trigger was cow's milk. As compared to older preschool children, hives, hypotonia and hypotension were more likely to be reported in infants. We believe that this represents a distinct food anaphylaxis phenotype that can further support developing the clinical anaphylaxis criteria in infants.
Automatic three‐dimensional analysis of bone volume and quality change after maxillary sinus augmentation
Authors: Kwon Jin‐Ju , Hwang JaeJoon , Kim Yong‐Deok , Shin Sang‐Hun , Cho Bong‐Hae , Lee Jae‐Yeol 
Published: October 2019

AbstractIntroductionMaxillary sinus augmentation is a widely used surgical procedure to increase the bone volume before implant placement. In order to predict the stability of the implant, analysis of the change in bone volume and quality after a sinus graft procedure is necessary. The purpose of this study was to analyze the change in volume and quality of bone graft material after maxillary sinus augmentation using cone beam computed tomography (CBCT).Methods and MaterialsMaxillary sinus lift procedures using bovine bone materials (Bio‐Oss, Geistrich, Swiss) without immediate implantation were performed at the Pusan National University Dental Hospital in 22 patients, from 2014 to 2017. CBCT images were captured before surgery (T1), a day after surgery (T2), and after 4 to 7 months at follow‐up (T3). The T2 and T3 images were registered to the T1 image using histogram matching and intensity‐based registration. A total of 30 sinuses were analyzed three‐dimensionally (3‐D), using self‐made software MATLAB 2018a (MathWorks, Natick, Massachusetts). The volume and structural indices of the bone graft material were measured and analyzed.ResultsThe average volume of graft material showed a decrease, while the average gray value showed an increase during the follow‐up period, but these changes were not statistically significant. The structural indices of the graft material after histogram matching showed a significant difference in homogeneity, connectivity, thickness, and roughness at the postoperative follow‐up.ConclusionsThe volume and gray value showed no statistically significant changes after the maxillary sinus lift procedures. The results of this study show that structural analysis using histogram matching can be used as a promising tool to analyze the quality of graft materials.
Early elevated neutrophil‐to‐lymphocyte ratio associated with remote diffusion‐weighted imaging lesions in acute intracerebral hemorrhage
Authors: Li Jia‐Wen , Xu Yu‐Yu , Chen Ye‐Jun , Fan Wei‐Wei , Xu Xu‐Hua , Cai Jin‐Song , Tong Lu‐Sha , Gao Feng 
Published: October 2019

AbstractAimsTo explore the relationship between the circulating neutrophil‐to‐lymphocyte ratio (NLR) and the remote diffusion‐weighted imaging lesions (R‐DWILs) after spontaneous intracerebral hemorrhage (ICH).MethodsConsecutive patients with spontaneous ICH were prospectively collected from November 2016 to May 2018 and retrospectively analyzed. We included subjects who presented within 24 hours after symptom onset and were free of detectable infections on admission or in hospital. Blood samples were obtained at 24‐48 hours after ICH ictus, while all complete MRI scans were performed at 5‐8 days. R‐DWILs were defined as focal hyperintensities remote from the site of the ICH or the peri‐hematoma regions. NLR was calculated by dividing the absolute neutrophil counts by the absolute lymphocyte counts. Multivariate binary logistic regression models were generated to evaluate the relationship between NLR and R‐DWILs.ResultsOne hundred sixty‐three subjects met eligibility criteria (age 62.3 ± 13.6 years, 60.7% males), of whom 31(19.0%) experienced R‐DWILs. Higher circulating NLR was documented in patients with R‐DWILs. With the best cutoff value of 6.01, elevated NLR was independently associated with the presence of R‐DWILs (OR = 3.170, 95% CI 1.306‐7.697, P = .011) in the bivariate logistic regression analysis with adjustment for age, sex, atrial fibrillation, previous ischemic stroke/TIA, SBP on admission, hematoma volume, and IVH.ConclusionsThis study provides significant evidence of the association between circulating NLR and R‐DWILs in spontaneous ICH patients. Patients with NLR > 6.01 at 24‐48 hours after ICH ictus should be paid more attention to when evaluating R‐DWILs.
Does board gender diversity influence voluntary disclosure of intellectual capital in initial public offering prospectuses? Evidence from China
Authors: Nadeem Muhammad 
Published: October 2019

AbstractResearch question/issueUsing a multitheoretic view of boards, this study examines the impact of boardroom gender diversity (BGD) on voluntary intellectual capital (IC) disclosure in initial public offering (IPO) prospectuses in China—the world's second‐biggest economy, which is moving from a planned economy to a market‐oriented one. Furthermore, this study also investigates the impact of family ownership on the relationship between BGD and IC disclosure in the Chinese environment, which is characterized by less‐developed corporate governance mechanisms.Research findings/insightsBased on a comprehensive content analysis of Chinese IPO prospectuses between 2009 and 2017 and measuring disclosure index at 78 dimensions under six broad categories of IC, the empirical results document (a) a significant positive relation between BGD and IC disclosure—in line with resource dependence theory, (b) a significant negative impact of female independent directors on IC disclosure—opposite to agency theory predictions, and that (c) the BGD–IC disclosure relationship is generally stronger for firms with two or more women on boards—in line with critical mass theory in China. Finally, this study also reveals that family ownership has adverse impacts on the BGD–IC disclosure relationship. These results are robust to a battery of sensitivity analyses.Practitioner/policy implicationsThis study provides positive capital market implications of BGD through enhanced IC disclosure in IPO prospectuses. In doing so, the study has important implications for regulators and top management teams in devising policies concerning female representation on boards and voluntary disclosure of IC to inform the market participants of the true value of the company.
Long‐term outcomes with oral therapy in liver transplant recipients with hepatitis B
Authors: Saab Sammy , Song Dana , Challita Youssef P. , Xiwen Zhou Tina , Saab Elena G. , Viramontes Matthew R. , Choi Gina , Durazo Francisco A. , Han Steven B. , El Kabany Mohammed M. , Jackson Nicholas J. , Busuttil Ronald W. 
Published: October 2019

AbstractBackgroundThe long‐term impact of oral hepatitis B antiviral therapy in liver transplant (LT) recipients is currently underexplored. The objective of this study was to evaluate how oral antiviral agents impact long‐term renal function in this population.MethodsWe studied 79 patients who received a LT for hepatitis B and were placed on all‐oral antiviral therapy after withdrawing from hepatitis B immune globulin therapy at the University of California, Los Angeles. Laboratory data were obtained through a retrospective chart review. Univariate analysis and two‐sided t tests were performed.ResultsThe mean (±SD [standard deviation]) age at the time of LT was 65.4 (± 8.2) years. The overall mean (±SD) follow‐up from LT was 6.5 (±3.3) years. 22.8% (18/79) of recipients on all‐oral therapy had worsening of their chronic kidney disease stage, and 17.7% (14/79) had an increase in creatinine of at least 0.3 mg/dL. There were no significant changes in creatinine and GFR in patients while on tenofovir alafenamide. Patient survival was decreased for recipients who developed detectable HBsAg.ConclusionTenofovir alafenamide appears to have less of an impact on renal function in LT recipients than other antiviral agents. HBV recurrence after transplant is associated with decreased patient survival and remains an important issue to address for LT recipients on oral antiviral therapy.
Safety, Tolerability, Pharmacokinetics, Target Occupancy, and Concentration‐QT Analysis of the Novel BTK Inhibitor Evobrutinib in Healthy Volunteers
Authors: Becker Andreas , Martin Emily C. , Mitchell David Y. , Grenningloh Roland , Bender Andrew T. , Laurent Julien , Mackenzie Harald , Johne Andreas 
Published: October 2019

Bruton's tyrosine kinase (BTK) is a key regulator of B cell receptor and Fc receptor signaling, and a rational therapeutic target for autoimmune diseases. This first‐in‐human phase I, double‐blind, placebo‐controlled trial investigated the safety, tolerability, pharmacokinetics (PK), target occupancy, and effects on QT interval of evobrutinib, a highly selective, oral inhibitor of BTK, in healthy subjects. This dose escalation trial consisted of two parts. Part 1 included 48 subjects in 6 ascending dose cohorts (25, 50, 100, 200, 350, and 500 mg) randomized to a single dose of evobrutinib or placebo. Part 2 included 36 subjects in 3 ascending dose cohorts (25, 75, and 200 mg/day) randomized to evobrutinib or placebo once daily for 14 days. Safety and tolerability, as well as PK and target occupancy (total and free BTK in peripheral blood mononuclear cells), were assessed following single and multiple dosing. PK parameters were determined by noncompartmental methods. QT interval was obtained from 12‐lead electrocardiogram recordings and corrected for heart rate by Fridericia's method (QTcF). Treatment‐emergent adverse events (TEAEs) were mostly mild, occurring in 25% of subjects after single dosing, and 48.1% after multiple dosing. There was no apparent dose relationship regarding frequency or type of TEAE among evobrutinib‐treated subjects. Absorption was rapid (time to reach maximum plasma concentration (Tmax) ~ 0.5 hour), half‐life short (~ 2 hours), and PK dose‐proportional, with no accumulation or time dependency on repeat dosing. BTK occupancy was dose‐dependent, reaching maximum occupancy of > 90% within ~ 4 hours after single doses ≥ 200 mg; the effect was long‐lasting (> 50% occupancy at 96 hours with ≥ 100 mg). After multiple dosing, full BTK occupancy was achieved with 25 mg, indicating slow turnover of BTK protein in vivo. Concentration‐QTcF analyses did not show any impact of evobrutinib concentration on corrected QT (QTc). In summary, evobrutinib was well‐tolerated, showed linear and time‐independent PK, induced long‐lasting BTK inhibition, and was associated with no prolongation of QT/QTc interval in healthy subjects. Evobrutinib is, therefore, suitable for investigation in autoimmune diseases.
Body size, but not age‐at‐maturation or context, affects the expression of predator‐induced behavioural plasticity in female green swordtails (Xiphophorus hellerii)
Authors: DiSciullo Rachael A. , Basolo Alexandra L. 
Published: October 2019

AbstractBehavioural plasticity is a form of reversible phenotypic plasticity in which a genotype can express different behavioural phenotypes under different environmental conditions. Though an interest in among‐individual differences in behavioural plasticity has flourished in recent decades, few studies have considered the effects of intrinsic factors, such as life‐history or morphological traits, in tandem with extrinsic factors, such as presence of conspecifics in different social contexts, on predator‐induced behavioural plasticity. Here, we present a study conducted with female green swordtail fishes, Xiphophorus hellerii, designed to assess the effects of age‐at‐maturation and body size on the expression of predator‐induced behavioural plasticity in two social contexts: (a) female‐only (two females) and (b) female‐and‐male (two females and a male). We further examined the extent to which individual expression of behavioural plasticity is consistent across these two social contexts. We found that in the presence of a predator, focal females were more timid in response to the stimulus and more tolerant of the non‐focal female, and small females expressed this change from bold/less tolerant to timid/more tolerant to a greater degree than large females, regardless of age‐at‐maturation. However, individuals were not consistent in the degree or direction of plasticity expressed in the behaviours of interest between the female‐only and the female‐and‐male context. Here, we show that within‐ and among‐individual differences in behavioural expression are common but inconsistent. How intrinsic and extrinsic factors independently or together drive expression of plasticity in antipredator and agonistic behaviours is varied and warrants further study.
A selective and low impacting traditional fishery, sustaining the economy of small coastal villages in central Mediterranean: Keep or replace the small‐scale driftnets?
Authors: Sartor Paolo , Carbonara Pierluigi , Cerasi Sandro , Lembo Giuseppe , Facchini Maria Teresa , Lucchetti Alessandro , Sabatella Rosaria Felicita , Musumeci Claudia , Zupa Walter , Spedicato Maria Teresa 
Published: October 2019

AbstractSmall‐scale driftnets (SSDs) have been historically used in the Mediterranean without major environmental concern. The introduction of large‐scale driftnets caused unwanted catches of protected species. Specific regulations were therefore issued in European waters, culminating in a proposed moratorium on SSDs. This study aimed to characterise the SSD fishery targeting anchovy (menaide), evaluating its environmental sustainability, economic performance and social relevance. In 2013, a survey by interviews, logbooks and observers on board assessed the order of magnitude of this fishery in terms of fishing capacity and activity, volume of landings and revenues. The menaide fleet consisted in 60 vessels <12 m overall length, moored in little harbours in southern Italy. These nets are highly selective: the target species, European anchovy, Engraulis encrasicholus (L.) and sardine, Sardina pilchardus (Walbaum), dominates the catches, while discards are negligible. The anchovies caught are of high quality and large size; the high prices support fish processing by local factories. Moreover, the results of a SWOT analysis demonstrated that replacing SSDs with a semi‐industrial fishery, like purse seining, would increase impacts on the ecosystem, and a loss of socio‐economic opportunities for several coastal villages. These findings support the option of keeping SSDs operating, in the framework of specifically oriented management measures.
Riverine transport and nutrient inputs affect phytoplankton communities in a coastal embayment
Authors: Farrow Christopher R. , Ackerman Josef D. , Smith Ralph E. H. , Snider Dave 
Published: October 2019

Abstract

Rivers often transport phytoplankton to coastal embayments and introduce nutrients that can enrich coastal plankton communities. We investigated the effects of the Nottawasaga River on the nearshore (i.e. within 500 μm of shore) phytoplankton composition along a 10‐km transect of Nottawasaga Bay, Lake Huron in 2015 and 2016. Imaging flow cytometry was used to identify and enumerate algal taxa, which were resolved at sizes larger than small nanoplankton (i.e. >5 μm). Multivariate analysis (perMANOVA and redundancy analysis) and a dilution model were used to examine how nutrients and the transport of algal taxa affected community composition in the bay.

Sampling stations with different percentages of river water had significantly different phytoplankton communities. Phytoplankton community composition was also strongly associated with nutrients, including total phosphorus, which also varied with the percentage of river water. The majority of the 51 phytoplankton taxa identified in 2016 had numerical abundances in the bay that could be explained simply by the dilution of incoming river water.

Phytoplankton transported from the river had a higher proportion of edible‐sized cells (<30 μm), particularly in summer when colonial cyanobacteria were numerically dominant in the bay. Six taxa were more abundant than expected from the dilution of river water and included some cyanobacteria with late summer maxima. Five of the taxa that were transported from the river were less abundant than expected in the bay.

Whereas impacts of fertilisation due to the characteristically higher nutrient concentration in the river are to be expected, the strong and highly correlated effects of transport within the narrow coastal band of this study largely concealed any distinct fertilisation effects.

Riverine inputs may strongly influence the nearshore assemblage of phytoplankton in oligotrophic embayments in large lakes, creating hotspots for productivity, species turnover, and trophic dynamics.
Clarifying effect of different fining agents on mulberry wine
Authors: Ren Mengmeng , Liu Sudian , Li Ruilong , You Yilin , Huang Weidong , Zhan Jicheng 
Published: October 2019

AbstractFining experiments have been conducted on mulberry wine, in which five fining agents (bentonite, gelatin, casein, egg albumin and PVPP) were investigated. The effect of these agents on polyphenol content, colour intensity, antioxidant activity and aromatic profile has been determined. In general, all treatments improved the limpidity of the mulberry wines to some extent. The wine was mostly negatively affected by gelatin and led to the greatest reduction of phenol content (16.61%), colour intensity (32.26%) and antioxidant activity. Concerning aroma, the addition of PVPP, casein and bentonite both significantly altered the aroma profile. It is noteworthy that egg albumin led to the lowest diminution total phenol value (5.74%) and improvement of antioxidant capacity and colour among the tested fining agents. Furthermore, the aroma profile remained mostly unaffected by egg albumin. As consequence, the optimal fining agent for mulberry wine was egg albumin.
Noncontact temperature‐dependent fluorescence depicting phase transition in Nd3+‐doped (K0.5Na0.5)NbO3 ceramics
Authors: Wang Huajing , Deng Baoyu , Lin Cong , Wu Xiao , Cheng Yao , Lin Tengfei , Zheng Xinghua , Yu Xing 
Published: October 2019

AbstractA noncontact temperature measurement technique based on fluorescence variation was used to depict the temperature‐dependent evolution of phase transition of a ferroelectric material, that is, Nd3+‐doped (K0.5Na0.5)NbO3 ceramics. The slope of the fluorescence intensity curve changes dramatically in the two temperature regions of 450‐475 K and 650‐675 K, which correspond to orthorhombic‐tetragonal and tetragonal‐cubic transitions as confirmed by the temperature dependence of dielectric constant. Furthermore, the small deviations in δTO‐T and δTc indicate the good accuracy of this noncontact method. This work can guide other ergodic ferroelectrics to describe phase experience by the noncontact fluorescence method.
Management of granulomatous foreign body reaction to fillers with methotrexate
Authors: Broly M. , Marie J. , Picard C. , Demoures A. , Raimbault C. , Beylot‐Barry M. , Cogrel O. 
Published: October 2019

AbstractBackgroundGranulomatous foreign body reactions (GFBR) have been reported after injection with almost every soft tissue fillers, more commonly with non‐biodegradable ones. Such granulomatosis is rare but can cause significant discomfort owing to their aesthetic and functional repercussions.ObjectiveTo determine whether immunomodulation with low doses of methotrexate is effective in the treatment of GFBR to filler material.MethodsClinical case series of four patients with severe, treatment‐resistant GFBR to non‐biodegradable fillers in the Department of Dermatology of Bordeaux University Hospital, Bordeaux, France, successfully treated with oral or subcutaneous methotrexate, 10–15 mg weekly during 6 months. Adverse events were monitored throughout the treatment once weekly the first month then once monthly the remaining 5 months.ResultsFour women with a mean age of 73.7 years (66–85 years) and nodularity of the face were included and treated up to 6 months. Histological findings were consistent with GFBR to liquid injectable silicone in 2 cases, polymethylmethacrylate in 1 case and hydroxyethylmethacrylate in the last case. The delay after injection of the filler material was from 17 to 30 years. In one patient, inflammatory lesions followed dental care. After 6 months of treatment with 10–15 mg once weekly, all patients were cleared. Three patients developed a mild hepatic cytolysis (grade 1 or 2). Methotrexate could be maintained in those 3 cases and was discontinuated after 6 months in all cases. Two patients developed recurrence of lesions, 28 and 9 months, respectively, after treatment stops, requiring reintroduction of treatment. The two other patients remained cleared after 6 months of follow‐up.ConclusionLow doses of methotrexate appear to offer a low‐risk therapeutic alternative in resistant and severe GFBR to fillers. A prospective study with long‐term follow‐up is required to confirm these preliminary observations.
Caregiving in Crisis: Fatherhood Refashioned by Sierra Leone's Ebola Epidemic
Authors: McLean Kristen E. 
Published: October 2019

AbstractIn much of the literature on Sierra Leone, young men have been recognized for perpetrating violence or resisting authority. This characterization extended into the Ebola crisis, as young men were depicted as “resisting” public health measures. In contrast, little scholarship has focused on men's roles as caregivers during the epidemic. This article draws on ethnographic research conducted between 2014 and 2016 in eastern Sierra Leone to demonstrate how men contributed to caregiving. Findings reveal that when men were unable to care via established means, they improvised new ways to care for their families, which included: paid labor in Ebola treatment facilities; protecting their families from risk of infection; and hands‐on nurturing. By focusing on these diverse types of male caregiving, this article challenges the ways in which “care” and “women” are often neatly linked and calls for a rethinking of stereotypes associating African men with violence