bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimización de flujos de trabajo y paneles de cribado para la detección de gammapatias monoclonales malignas
Authors: Oliveros Conejero Raquel , Pascual Usandizaga Pilar , Garrido Chércoles Adolfo 
Published: August 2020

Resumen

Objetivos
El mieloma múltiple (MM) es una de las malignidades hematológicas con más retraso en el diagnóstico. Frecuentemente, llegan al laboratorio peticiones de técnicas de detección de MM sin sospecha específica generando mucha carga de trabajo y baja eficiencia. Objetivo: aumentar la eficiencia de aplicación de los protocolos de cribado del MM.

Métodos
Recopilación de resultados de electroforesis (EPS) e inmunofijación en suero (IFS) y orina (IFO), y de cadenas ligeras libres en suero (CLLS) de 75 pacientes de MM al diagnóstico, 3 amiloidosis y un plasmocitoma solitario. Recopilamos las alteraciones analíticas presentes en estos pacientes vs población control (n.=120). Validación del algoritmo de cribado en 261 pacientes consecutivos con sospecha clínica o analítica de MM.

Resultados
Algoritmos de cribado más sensibles: EPS + CLLS o IFS + CLLS (98% de sensibilidad). Prospectivamente, el protocolo EPS + CLLS detectó 27 de las 28 gammapatia monoclonal (GM) diagnosticadas y ahorró 15 h laborales. Frecuencia de resultados analíticos alterados, 5 de los 6 parámetros eran más frecuentes en el grupo a estudio, acumulando ≥3 parámetros alterados el 61,1% vs. el 1,7% de la población control (Valor predictivo positivo: 85%; Valor predictivo negativo: 94%).

Conclusiones
El protocolo de cribado EPS + CLLS fue el más sensible y menos laborioso. Además, permitió mejorar la sensibilidad diagnóstica y la eficiencia de trabajo.
King type generalization of Baskakov operators based on (𝑝, 𝑞) calculus with better approximation properties
Authors: Mishra Lakshmi Narayan , Pandey Shikha , Mishra Vishnu Narayan 
Published: August 2020

Abstract
Approximation using linear positive operators is a well-studied research area.
Many operators and their generalizations are investigated for their better approximation properties.
In the present paper, we construct and investigate a variant of modified

(
p
,
q
)

(p,q)

-Baskakov operators, which reproduce the test function

x
2

x^{2}

.
We have determined the order of approximation of the operators via K-functional and second order, the usual modulus of continuity, weighted and statistical approximation properties.
In the end, some graphical results which depict the comparison with

(
p
,
q
)

(p,q)

-Baskakov operators are explained and a Voronovskaja type result is obtained.
Self-Similar Blow-Up Profiles for a Reaction-Diffusion Equation with Strong Weighted Reaction
Authors: Iagar Razvan Gabriel , Sánchez Ariel 
Published: August 2020

Abstract
We study the self-similar blow-up profiles associated to the following second-order reaction-diffusion equation with strong weighted reaction and unbounded weight:

∂
t

⁡
u

=

∂

x
⁢
x

⁡

(

u
m

)

+

|
x
|

σ

⁢

u
p

,

\partial_{t}u=\partial_{xx}(u^{m})+|x|^{\sigma}u^{p},

posed for

x
∈
ℝ

{x\in\mathbb{R}}

,

t
≥
0

{t\geq 0}

, where

m
>
1

{m>1}

,

0
<
p
<
1

{0<p<1}

and

σ
>

2
⁢

(

1
-
p

)

m
-
1

{\sigma>\frac{2(1-p)}{m-1}}

. As a first outcome, we show that finite time blow-up solutions in self-similar form exist for

m
+
p

>
2

{m+p>2}

and σ in the considered range, a fact that is completely new: in the already studied reaction-diffusion equation without weights there is no finite time blow-up when

p
<
1

{p<1}

. We moreover prove that, if the condition

m
+
p

>
2

{m+p>2}

is fulfilled, all the self-similar blow-up profiles are compactly supported and there exist two different interface behaviors for solutions of the equation, corresponding to two different interface equations. We classify the self-similar blow-up profiles having both types of interfaces and show that in some cases global blow-up occurs, and in some other cases finite time blow-up occurs only at space infinity. We also show that there is no self-similar solution if

m
+
p

<
2

{m+p<2}

, while the critical range

m
+
p

=
2

{m+p=2}

with

σ
>
2

{\sigma>2}

is postponed to a different work due to significant technical differences.
Socrates’ First City:Pleonexiaand the Thought Experiment
Authors: Diaco Sara 
Published: August 2020

AbstractThe present study provides an analysis of Socrates’ account of the firstpolisinRepublic2 as a thought experiment and draws attention to the fact that Socrates combines both explanatory and evaluative aspects in his scenario. The paper further shows how the analysis of the city of pigs as a thought experiment can explain the lack ofpleonexiaby saving both the letter of the text, according to which there are no “pleonectic” desires in the city of pigs, and the fact that the firstpolisis nonetheless concerned with human beings. For, in contrast to the account offered by Glaucon earlier in Book 2, Socrates highlights our needs and lack of self-sufficiency as well as our compatibility with an advantageous and happy life in a community.
Young children’s language-based agency in multilingual contexts in Luxembourg and Israel
Authors: Schwartz Mila , Kirsch Claudine , Mortini Simone 
Published: August 2020

AbstractDrawing on two longitudinal case-studies, this study aimed to identify some salient characteristics of the agentic behaviour of two young emergent multilinguals in two different multilingual contexts: Luxembourg and Israel. Despite the fact that the studies were conducted independently, the two cases were analysed together owing to the similarities in the research methods such as video-recorded observations, and semi-structured interviews with teachers and parents. The data were analysed through thematic and conversational analyses. Findings showed that a boy who learned Luxembourgish in Luxembourg and a girl who learned Hebrew in Israel, were outgoing and active learners who influenced their learning environment. We identified 10 types of agentic behaviour, including engaging in repetition after peers and the teacher, creatively producing language, translanguaging, and self-monitoring. Despite differences of the children’s sociocultural and linguistic backgrounds, and the language policies of their educational settings, we found a striking overlap in their language-based agentic behaviours. We suggest that the identified types can encourage further research in this field. Although our study with talkative children allowed us to observe many types of agentic behaviours, we cannot claim that less outgoing children or children who do not show the same behaviours do not have ways of expressing their agency.
Transportmodelle für Flüssigkeitsfilme
Authors: Hofmann Julian , Ponomarev Anton , Hagenmeyer Veit , Gröll Lutz 
Published: August 2020

ZusammenfassungDer Beitrag behandelt Modelle für Flüssigkeitsfilme in Rohrleitungen. Da sich das Ein-/Ausgangsverhalten von Flüssigkeitsfilmen nur in grober Näherung mit klassischen Transportmodellen beschreiben lässt, werden zwei neue Modelle entwickelt. Letztere basieren auf Liquidelementen und sind auf andere Transportprozesse, bspw. im Verkehrsfluss, übertragbar. Zusammen mit den jeweiligen Modellannahmen führen fundamentale Bilanzgleichungen auf quasilineare partielle Differentialgleichungen erster Ordnung, die mittels des Charakteristikenverfahrens in retardierte Ein-/Ausgangsgleichungen überführt werden. Diese Darstellung ist für den Reglerentwurf und die Simulation vorteilhaft. Der praktische Hintergrund des Beitrags ist der Fallfilmverdampferprozess. Daher werden die beiden Modelle hinsichtlich des beobachteten Ein-/Ausgangsverhaltens von Fallfilmverdampfern verglichen.
Multi-objective model predictive control for microgrids
Authors: Schmitt Thomas , Rodemann Tobias , Adamy Jürgen 
Published: August 2020

AbstractEconomic model predictive control is applied to a simplified linear microgrid model. Monetary costs and thermal comfort are simultaneously optimized by using Pareto optimal solutions in every time step. The effects of different metrics and normalization schemes for selecting knee points from the Pareto front are investigated. For German industry pricing with nonlinear peak costs, a linear programming trick is applied to reformulate the optimization problem. Thus, together with an efficient weight determination scheme, the Pareto front for a horizon of 48 steps is determined in less than 4 s.
Grundprinzipien für die Abschätzung von Einzugsbereichen in Totzeitsystemen
Authors: Scholl Tessina H. , Hagenmeyer Veit , Gröll Lutz 
Published: August 2020

Zusammenfassung
Für Ruhelagen autonomer retardierter Funktionaldifferentialgleichungen werden Konzepte zur Abschätzung des Einzugsbereichs abgeleitet. Diese stützen sich auf Verallgemeinerungen der direkten Methode von Lyapunov und des LaSalle-Invarianzprinzips. Bei totzeitfreien gewöhnlichen Differentialgleichungen lassen sich Untermengen des Einzugsbereichs durch Subniveaumengen von Lyapunov-Funktionen beschreiben. Im Gegensatz dazu kann bei totzeitbehafteten Systemen gegebenenfalls keine nichtleere Subniveaumenge eines entsprechenden Lyapunov-Krasovskii-Funktionals in das Monotoniegebiet einbeschrieben werden. Der vorliegende Beitrag gibt zulässige Einschränkungen der Subniveaumengen an, um dieses Problem zu lösen. Zudem werden numerische Methoden beschrieben, die auf Oberschranken des Einzugsradius schließen lassen.
Did Right-To-Work Laws Impact Income Inequality? Evidence from U.S. States Using the Synthetic Control Method
Authors: Jordan Jeffrey , Mathur Aparna , Munasib Abdul , Roy Devesh 
Published: August 2020

Abstract
In this paper, we use the Synthetic Control Method (SCM) to examine the impact of a state’s adoption of a Right-To-Work (RTW) law on income inequality. We explore possible pathways through which RTW laws may impact inequality, namely, unionization, investment, and wages. Our finding of a lack of impact of RTW laws on inequality is further supported by findings of a lack of impact of the law on these variables. Our results follow Farber (1984), who suggests that RTW laws may simply mirror pre-existing preferences against union representation. Hence RTW laws are not the primary driver of changes in inequality.
Evaluating Changes in the Transmission Mechanism of Government Spending Shocks
Authors: Rebei Nooman 
Published: August 2020

Abstract
We empirically revisit the crowding-in effect of government spending on private consumption based on rolling windows of U.S. data. Results show that in earlier samples government spending is increasingly crowding in private consumption; however, this relation is reverted in the latest periods. We propose a model embedding non-separable public and private consumption in the utility function and rule-of-thumb consumers to assess the sources of non-monotonic changes in the transmission of the shock. The iterative full information estimation of the model reveals that changes in the co-movement between private and public spending is primarily driven by the fluctuations in the elasticity of substitution between private and public consumption, the share of financially constrained consumers, and the elasticity of intertemporal substitution.
Social Coordination and Network Formation in Bipartite Networks
Authors: Jiang Ge 
Published: August 2020

Abstract
In this paper, we consider a model of social coordination and network formation, where players of two groups play a 2 × 2 coordination game when they are connected. Players in one group actively decide on whom they play with and on the action in the game, while players in the other group decide on the action in the game only and passively accept all the connections from the active group. The players in the active group can connect to a limited number of opponents in the other group. We find that the selection of long-run outcomes is determined by the population size of each group, not the overall population size of them. If either group’s population size is small in comparison to the number of maximally allowed links, all players will choose the risk-dominant equilibrium, while when both groups are sufficiently large with respect to the number of maximally allowed links, the players of the two groups will coordinate on the payoff-dominant action.
Analysis of autonomic nervous pattern in hypertension based on short-term heart rate variability
Authors: Zhang Ruiqi , Hua Zhengchun , Chen Chen , Liu Guangyuan , Wen Wanhui 
Published: August 2020

Abstract
Physiological studies have found that the autonomic nervous system plays an important role in controlling blood pressure values. This paper, based on machine learning approaches, analysed short-term heart rate variability to determine differences in autonomic nervous function between hypertensive patients and normal population. The electrocardiogram (ECG) of hypertensive patients are 137 ECG recordings provided by Smart Health for Assessing the Risk of Events via ECG (SHAREE database). The RR intervals of healthy subjects include the data of 18 subjects from the MIT-BIH Normal Sinus Rhythm Database (nsrdb) and 54 subjects from the Normal Sinus Rhythm RR Interval Database (nsr2db). In this paper, each RR segment includes continuous 500 beats. Seventeen features were extracted to distinguish the hypertensive heart beat rhythms from the normal ones, and Kolmogorov-Smirnov test and sequential backward selection (SBS) were applied to get the best feature combinations. In addition, support vector machine (SVM), k-nearest neighbor (KNN) and random forest (RF) were applied as classifiers in the study. The performance of each classifier was evaluated independently using the leave-one-subject-out validation method. The best predictive model was based on RF and enabled to identify hypertensive patients by five features with an accuracy of 86.44%. The best five HRV features are sample entropy (SampEn), very low frequency spectral powers (VLF), root mean square of successful differences (RMSSD), ratio of low frequency spectral powers and high frequency spectral powers (LF/HF) and vector angle index (VAI). The results of the study show sympathetic overactivity and decreased parasympathetic tone in hypertensive patients.
Controlled differential evolution based detection of neovascularization on optic disc using support vector machine
Authors: Biswal Birendra , P. Geetha Pavani , Biswal Pradyut K. 
Published: August 2020

Abstract
The severe stage of Diabetic Retinopathy (DR) is characterized by the growth of new blood vessels which is called Neovascularization (NV). The abnormally grown blood vessels on the disc are breakable in nature thus the patient is at high risk of sudden blindness. Therefore, the significance of early and accurate detection of Neovascularization on Disc (NVD) should not be neglected. This paper presents an automatic detection of the optic disc using a Controlled Differential Evolution (CDE) algorithm. Further, the Region of Interest (ROI) is created automatically by extending the extreme boundaries of the optic disc by 100 pixels to ensure the presence of NV around the optic disc also. From the ROI so created, blood vessels are segmented using multi-scale Gabor filtering and subsequently, both the morphological and textural features are extracted. Simultaneously, statistical features are directly extracted from the earlier created ROI. Finally, the fundus image is classified by a Support Vector Machine (SVM) using the extracted features from all three feature sets. From each individual image, 16 features are extracted and the feature dimension is reduced to 13 using a sequential backward feature (SBF) selection algorithm. The optimal features are obtained from a total of 205 fundus images, which consists of 99 NVD positive and 106 NVD negative images. This paper attains an average accuracy of 98.75%, the specificity of 100%, the sensitivity of 97.8%, and area under the curve (AUC) as 100% when tested over image selected randomly.
Development of trace analysis for alkyl methanesulfonates in the delgocitinib drug substance using GC-FID and liquid–liquid extraction with ionic liquid
Authors: Nomura Shinkichi , Ito Yoshiharu , Takegami Shigehiko , Kitade Tatsuya 
Published: August 2020

AbstractAlkyl methanesulfonates are genotoxic impurities that should be limited to an intake of not more than 1.5 µg/day, as regulated by the International Council for Harmonization guideline M7. We herein report a trace analysis of methyl methanesulfonate (MMS), ethyl methanesulfonate (EMS), and isopropyl methanesulfonate (IPMS) in the delgocitinib drug substance using liquid–liquid extraction, with an ionic liquid as the sample-solving medium, and direct injection gas chromatography detected with a flame-ionization detector. The proposed method takes advantage of the fine solubility of ionic liquids toward the drug substance, the good extraction efficiency of alkyl methanesulfonates in liquid–liquid extraction using the Chem Elut cartridge with low-polar organic solvents, and the ability of alkyl methanesulfonates to concentrate in minimum amounts of organic solvent, resulting in excellent sensitivity and selectivity. Specifically, for the preparation of the sample solution, a mixture of 1-butyl-3-methylimidazolium chloride, water, and acetonitrile was used as the sample-solving media, extracted with diethyl ether, and the eluent was concentrated to 1 mL. The method showed good linearity, accuracy, and precision from 1 to 5 ppm, and the limits of detection of MMS, EMS, and IPMS were 0.1, 0.05, and 0.05 ppm, respectively.
Quasi-Optimal and Pressure Robust Discretizations of the Stokes Equations by Moment- and Divergence-Preserving Operators
Authors: Kreuzer Christian , Verfürth Rüdiger , Zanotti Pietro 
Published: August 2020

Abstract
We approximate the solution of the Stokes equations by a new
quasi-optimal and pressure robust
discontinuous Galerkin discretization of arbitrary order.
This means quasi-optimality of the velocity error independent of the
pressure. Moreover, the discretization is well-defined for any load
which is admissible for the continuous problem and it also provides
classical quasi-optimal estimates for the sum of velocity and pressure
errors. The key design principle is a careful discretization of the
load involving a linear operator, which maps discontinuous
Galerkin test functions onto conforming ones thereby preserving the
discrete divergence and certain moment conditions on faces and elements.
Whose media are hostile? The spillover effect of interpersonal discussions on media bias perceptions
Authors: Castro Laia , Hopmann David Nicolas , Nir Lilach 
Published: August 2020

AbstractSince Eveland and Shah (2003) published their seminal study on the impact of social networks on media bias perceptions in the US, little has been researched about the interpersonal antecedents of hostile media perceptions. In this study we address this gap by investigating the role of safe, or like-minded, political discussions on individuals’ likelihood to perceive media as hostile. We use survey data from more than 5,000 individuals in Germany. Our findings reveal that like-minded discussions increase one’s likelihood to perceive media as hostile; yet, only among those more politically engaged and ideologically on the left. The significance and theoretical implications of the results are discussed in the concluding section.
Robust optimal centralized PI controller for a fluid catalytic cracking unit
Authors: Yadav Gourav , Kiran Gundla Uday , Rao Chinta Sankar 
Published: August 2020

Abstract
Fluidized Catalytic Cracking (FCC) is a complex process that arises due to feed composition, non-linearities, and dynamic mass and heat interactions in its components. FCC is difficult to model and monitor in industries, and one of the key reasons is that they are multivariable processes. Such processes are highly interacting and that makes the process of controlling even more difficult. The interaction between loops can be quantified easily by dRGA. An easy and effective way of controlling multivariable processes is to implement a centralized control system, considering the interactions between measured and manipulated variables. In this study, a centralized control system is designed for the riser section of the FCC unit. The dRGA method is modified to enhance the closed-loop response by formulating an optimization problem and obtaining an optimal controller settings. A rigorous simulation studies show an 826% reduction in ISE values, a 309% reduction in IAE values, and a 262% reduction in ITAE value of

T

r
i
s

${T}_{ris}$

from the dRGA method to the modified dRGA method. Further, IAE values for

Y

l
p
g

${Y}_{lpg}$

are reduced by 29% from dRGA to modified dRGA method and 34% from synthesis to modified dRGA method.
The index conjecture for symmetric spaces
Authors: Berndt Jürgen , Olmos Carlos 
Published: August 2020

Abstract
In 1980, Oniščik [A. L. Oniščik,
Totally geodesic submanifolds of symmetric spaces,
Geometric methods in problems of algebra and analysis. Vol. 2,
Yaroslav. Gos. Univ., Yaroslavl’ 1980, 64–85, 161] introduced the index of a Riemannian symmetric space as the minimal codimension of a (proper) totally geodesic submanifold. He calculated the index for symmetric spaces of rank

≤
2

{\leq 2}

, but for higher rank it was unclear how to tackle the problem. In [J. Berndt, S. Console and C. E. Olmos,
Submanifolds and holonomy, 2nd ed.,
Monogr. Res. Notes Math.,
CRC Press, Boca Raton 2016],
[J. Berndt and C. Olmos,
Maximal totally geodesic submanifolds and index of symmetric spaces,
J. Differential Geom. 104 2016, 2, 187–217],
[J. Berndt and C. Olmos,
The index of compact simple Lie groups,
Bull. Lond. Math. Soc. 49 2017, 5, 903–907],
[J. Berndt and C. Olmos,
On the index of symmetric spaces,
J. reine angew. Math. 737 2018, 33–48],
[J. Berndt, C. Olmos and J. S. Rodríguez,
The index of exceptional symmetric spaces,
Rev. Mat. Iberoam., to appear] we developed several approaches to this problem, which allowed us to calculate the index for many symmetric spaces. Our systematic approach led to a conjecture, formulated first in [J. Berndt and C. Olmos,
Maximal totally geodesic submanifolds and index of symmetric spaces, J. Differential Geom. 104 2016, 2, 187–217], for how to calculate the index. The purpose of this paper is to verify the conjecture.
Large deviations of generalized renewal process
Authors: Bakay Gavriil A. , Shklyaev Aleksandr V. 
Published: August 2020

AbstractLet (ξ(i), η(i)) ∈ ℝd+1, 1 ≤ i < ∞, be independent identically distributed random vectors, η(i) be nonnegative random variables, the vector (ξ(1), η(1)) satisfy the Cramer condition. On the base of renewal process, NT = max{k : η(1) + … + η(k) ≤ T} we define the generalized renewal process ZT = $\begin{array}{}
\sum_{i=1}^{N_T}
\end{array}$ξ(i). Put IΔT(x) = {y ∈ ℝd : xj ≤ yj < xj + ΔT, j = 1, …, d}. We find asymptotic formulas for the probabilities P(ZT ∈ IΔT(x)) as ΔT → 0 and P(ZT = x) in non-lattice and arithmetic cases, respectively, in a wide range of x values, including normal, moderate, and large deviations. The analogous results were obtained for a process with delay in which the distribution of (ξ(1), η(1)) differs from the distribution on the other steps. Using these results, we prove local limit theorems for processes with regeneration and for additive functionals of finite Markov chains, including normal, moderate, and large deviations.