Atividade antifúngica do óleo essencial de Cymbopogon winterianus contra Candida não-albicans de importância clínica no atendimento pediátrico
Authors: Lima Ana Luísa de Araújo , Oliveira Filho Abrahão Alves de , Pérez Ana Luíza Alves de Lima , Sousa Janiere Pereira de , Pinheiro Lilian Sousa , Diniz Neto Hermes , Siqueira Júnior José Pinto de , Lima Edeltrudes de Oliveira 
Published: June 2020

Introdução: Devido às altas taxas de mortalidade, a candidemia têm se tornado um grave problema de saúde na realidade pediátrica, sobretudo quando se considera o aumento de infecções e a letalidade dos casos em grupos de risco como as crianças hospitalizadas e com sistema imunológico deficiente. Ultimamente têm-se percebido um aumento de infecções fúngicas provocadas por espécies não-albicans, trazendo uma nova realidade para o combate destas infecções, especialmente por envolver espécies resistentes à terapia convencional. Já foi demonstrado que o óleo essencial de Cymbopogon winterianus possui uma vasta gama de propriedades farmacológicas, incluindo atividade antifúngica. Objetivo: Este trabalho buscou avaliar a atividade antifúngica do óleo essencial de Cymbopogon winterianus Jowitt ex Bor (Poaceae) contra isolados de Candida não-albicans de importância clínica pediátrica. Material e Método: A concentração inibitória mínima (CIM) e a concentração fungicida mínima (CFM) foram determinadas pelas técnicas de microdiluição em caldo. Resultados: Tanto a CIM50 quanto a CFM50 do óleo essencial de C. winterianus para os isolados testados foi de 128 μg/mL.Conclusão: Este produto natural apresentou potencial antifúngico in vitro contra cepas de Candida não-albicans clinicamente relevante para a pediatria médica. Contudo, mais estudos são necessários para elucidar seu mecanismo de ação.Descritores: Técnicas de Tipagem Micológica; Candida; Candidemia; Cymbopogon; Óleos; Pediatria.ReferênciasSteinbach WJ. Pediatric invasive candidiasis: epidemiology and diagnosis in children. J Fungi (Basel). 2016;2(1):5.Ruiz LS, Khouri S, Hahn RC, da Silva EG, de Oliveira VK, Gandra RF et al. Candidemia by species of the Candida parapsilosis complex in children’s hospital: prevalence, biofilm production and antifungal susceptibility. 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