bluuebunny/crossref_metadata_2025_split huggingface dataset:
En bloc retroperitoneal laparoscopic radical nephrectomy with inferior vena cava thrombectomy for renal cell carcinoma with level 0 to II venous tumor thrombus: A single‐center experience
Authors: Tian Xiaojun , Hong Peng , Liu Zhuo , Huang Yi , Wang Guoliang , Hou Xiaofei , Zhang Shudong , Ma Lulin 
Published: April 2020

BackgroundThe surgical treatment of patients with renal cell carcinoma (RCC) with venous tumor thrombus (VTT) is challenging. In the current study, the authors have reported their surgical outcomes and experience with en bloc retroperitoneal laparoscopic radical nephrectomy (LRN) with inferior vena cava (IVC) thrombectomy for patients with RCC with level 0 to II VTT.MethodsA retrospective review of the clinical records of 78 patients who underwent retroperitoneal LRN with IVC thrombectomy from March 2015 to September 2018 was performed. The surgical procedures included establishing the retroperitoneal space, ligating and severing the renal artery, clamping the renal vein and IVC, incising the IVC, and placing the renal and tumor thrombus en bloc into a retrieval bag.ResultsAccording to the Mayo classification, the tumor thrombus was level 0, I, and II, respectively, in 28 patients, 27 patients, and 23 patients. The median operative time, estimated blood loss, and postoperative hospital stay were 256 minutes, 400 mL, and 8 days, respectively. A total of 67 patients were not converted to open surgery. No patient died during surgery, and no tumor embolization occurred. Thirteen patients experienced complications. The pathological reports indicated clear cell RCC in 70 patients and other RCC in 8 patients. The median follow‐up was 14.5 months, and 61 patients were alive at the time of last follow‐up.ConclusionsEn bloc retroperitoneal LRN with IVC thrombectomy is a challenging but feasible procedure for experienced surgeons in patients with RCC with level 0 to II VTT.
Enhanced Photoactivity and Photostability for Visible‐Light‐Driven Water Oxidation over BiFeO3 Porous Nanotubes by Modification of Mo Doping and Carbon Nanocoating
Authors: Zhang Hongyuan , Wang Li , Guo Changfa , Ning Jiqiang , Zhong Yijun , Hu Yong 
Published: April 2020

AbstractIn this study, an efficient visible‐light‐driven photocatalyst for water oxidation based on Mo doped BiFeO3 porous nanotubes (Mo‐BFO PNTs) was prepared through a facile electrospinning technique combined with a subsequent thermal treatment in air. The substitution of Mo for Fe in BFO lattice decreases the band gap of BFO, facilitates the separation of electron‐hole pairs, and reduces the interfacial charge transfer resistance, improving the O2 evolution rate of BFO by 3.0 times up to 643.6 μmol g−1 h−1 over the optimized Mo‐BFO PNTs. Furthermore, both photostability and photoactivity of Mo‐BFO PNTs can be improved by modification of the carbon nanocoating, which can effectively strengthen the structural stability of PNTs and suppress the aggregation. This work reports the Mo‐BFO modified with carbon nanocoating for photocatalytic water oxidation for the first time and provides new insights into the improvement of photocatalytic performance of semiconductors by metal doping and surface modification.
Recent Advances in the Development of Organic and Organometallic Redox Shuttles for Lithium‐Ion Redox Flow Batteries
Authors: Pham‐Truong Thuan‐Nguyen , Wang Qing , Ghilane Jalal , Randriamahazaka Hyacinthe 
Published: April 2020

AbstractIn recent years, redox flow batteries (RFBs) and derivatives have attracted wide attention from academia to the industrial world because of their ability to accelerate large‐grid energy storage. Although vanadium‐based RFBs are commercially available, they possess a low energy and power density, which might limit their use on an industrial scale. Therefore, there is scope to improve the performance of RFBs, and this is still an open field for research and development. Herein, a combination between a conventional Li‐ion battery and a redox flow battery results in a significant improvement in terms of energy and power density alongside better safety and lower cost. Currently, Li‐ion redox flow batteries are becoming a well‐established subdomain in the field of flow batteries. Accordingly, the design of novel redox mediators with controllable physical chemical characteristics is crucial for the application of this technology to industrial applications. This Review summarizes the recent works devoted to the development of novel redox mediators in Li‐ion redox flow batteries.
Research Progress in Lignin‐Based Slow/Controlled Release Fertilizer
Authors: Chen Jing , Fan Xiaolin , Zhang Lidan , Chen Xiaojuan , Sun Shaolong , Sun Run‐Cang 
Published: April 2020

AbstractAs a skeleton component of plants, lignin is an organic macromolecule polymer that can be regenerated and naturally degraded. Annually, plant growth produces about 150 billion tons of lignin. In industrial processes such as paper and biomass‐refining industry, large amounts of lignin are formed as by‐products. Most of technical lignins are directly combusted to obtain heat, which not only is a waste of organic matter but also leads to environmental pollution and other issues. Interestingly, lignin can be used as slow‐release carriers and coating materials for fertilizers due to its excellent slow release properties as well as chelating and other functionalities. Preparation of lignin‐based slow/controlled release fertilizers can be achieved by sustainable chemical (ammoxidation, Mannich reaction, and other chemical modifications), coating (without or with chemical modification), and chelation modifications. This Review systematically summarizes the methods, mechanisms, and application of the above methods for preparing lignin‐based slow/controlled release fertilizers. Although the evaluation standards and methods of lignin‐based slow/controlled release fertilizers are not perfect, it is believed that more and more scholars will pay more attention to them to accelerate the development and application of lignin‐based slow/controlled release fertilizers, so as to improve their relevant standards. In short, there is an urgent need to improve the preparation process of lignin‐based slow/controlled release fertilizers and application as lignin‐based slow/controlled release fertilizers to production practice as soon as possible.
Direct Z‐Scheme Heterojunction of SnS2/Sulfur‐Bridged Covalent Triazine Frameworks for Visible‐Light‐Driven CO2Photoreduction
Authors: Guo Shien , Yang Peng , Zhao Yanfei , Yu Xiaoxiao , Wu Yunyan , Zhang Hongye , Yu Bo , Han Buxing , George Michael W. , Liu Zhimin 
Published: April 2020

AbstractSolar‐driven reduction of CO2into renewable carbon forms is considered as an alternative approach to address global warming and the energy crisis but suffers from low efficiency of the photocatalysts. Herein, a direct Z‐Scheme SnS2/sulfur‐bridged covalent triazine frameworks (S‐CTFs) photocatalyst (denoted as SnS2/S‐CTFs) was developed, which could efficiently adsorb CO2owing to the CO2‐philic feature of S‐CTFs and promote separation of photoinduced electron–hole pairs. Under visible‐light irradiation, SnS2/S‐CTFs exhibited excellent performance for CO2photoreduction, yielding CO and CH4with evolution rates of 123.6 and 43.4 μmol g−1 h−1, respectively, much better than the most catalysts reported to date. This inorganic/organic hybrid with direct Z‐Scheme structure for visible‐light‐driven CO2photoreduction provides new insights for designing photocatalysts with high efficiency for solar‐to‐fuel conversion.
Across the Board: Hyunjoo Lee on Electrochemical CO2 Reduction
Authors: Lee Hyunjoo 
Published: April 2020

AbstractIn this series of articles, the board members of ChemSusChem discuss recent research articles that they consider of exceptional quality and importance for sustainability. This entry features Prof. Hyunjoo Lee, who discusses catalytic CO2 conversion into valuable chemicals using gas‐phase reduction and electrochemical reduction. She reveals how imminent demands for a more sustainable society might find solutions in electrochemically synthesized chemicals
Coregistered Spectral Optical Coherence Tomography and Two‐Photon Microscopy for Multimodal Near‐Instantaneous Deep‐Tissue Imaging
Authors: Rakhymzhan Asylkhan , Reuter Lucie , Raspe Raphael , Bremer Daniel , Günther Robert , Leben Ruth , Heidelin Judith , Andresen Volker , Cheremukhin Sergey , Schulz‐Hildebrandt Hinnerk , Bixel Maria G. , Adams Ralf H. , Radbruch Helena , Hüttmann Gereon , Hauser Anja E. , Niesner Raluca A. 
Published: April 2020

AbstractTwo‐photon microscopy (2PM) has brought unique insight into the mechanisms underlying immune system dynamics and function since it enables monitoring of cellular motility and communication in complex systems within their genuine environment—the living organism. However, use of 2PM in clinical settings is limited. In contrast, optical coherence tomography (OCT), a noninvasive label‐free diagnostic imaging method, which allows monitoring morphologic changes of large tissue regions in vivo, has found broad application in the clinic. Here we developed a combined multimodal technology to achieve near‐instantaneous coregistered OCT, 2PM, and second harmonic generation (SHG) imaging over large volumes (up to 1,000 × 1,000 × 300 μm3) of tendons and other tissue compartments in mouse paws, as well as in mouse lymph nodes, spleens, and femurs. Using our multimodal imaging approach, we found differences in macrophage cell shape and motility behavior depending on whether they are located in tendons or in the surrounding tissue compartments of the mouse paw. The cellular shape of tissue‐resident macrophages, indicative for their role in tissue, correlated with the supramolecular organization of collagen as revealed by SHG and OCT. Hence, the here‐presented approach of coregistered OCT and 2PM has the potential to link specific cellular phenotypes and functions (as revealed by 2PM) to tissue morphology (as highlighted by OCT) and thus, to build a bridge between basic research knowledge and clinical observations. © 2020 The Authors. Cytometry Part A published by Wiley Periodicals, Inc. on behalf of International Society for Advancement of Cytometry.
High‐Dimensional Data Analysis Algorithms Yield Comparable Results for Mass Cytometry and Spectral Flow Cytometry Data
Authors: Ferrer‐Font Laura , Mayer Johannes U. , Old Samuel , Hermans Ian F. , Irish Jonathan , Price Kylie M. 
Published: April 2020

AbstractThe arrival of mass cytometry (MC) and, more recently, spectral flow cytometry (SFC) has revolutionized the study of cellular, functional and phenotypic diversity, significantly increasing the number of characteristics measurable at the single‐cell level. As a consequence, new computational techniques such as dimensionality reduction and/or clustering algorithms are necessary to analyze, clean, visualize, and interpret these high‐dimensional data sets. In this small comparison study, we investigated splenocytes from the same sample by either MC or SFC and compared both high‐dimensional data sets using expert gating,t‐distributed stochastic neighbor embedding (t‐SNE), uniform manifold approximation and projection (UMAP) analysis and FlowSOM. When we downsampled each data set to their equivalent cell numbers and parameters, our analysis yielded highly comparable results. Differences between the data sets only became apparent when the maximum number of parameters in each data set were assessed, due to differences in the number of recorded events or the maximum number of assessed parameters. Overall, our small comparison study suggests that mass cytometry and spectral flow cytometry both yield comparable results when analyzed manually or by high‐dimensional clustering or dimensionality reduction algorithms such as t‐SNE, UMAP, or FlowSOM. However, large scale studies combined with an in‐depth technical analysis will be needed to assess differences between these technologies in more detail. © 2020 International Society for Advancement of Cytometry
A secure and efficient remote patient‐monitoring authentication protocol for cloud‐IoT
Authors: Alzahrani Bander A. , Irshad Azeem , Alsubhi Khalid , Albeshri Aiiad 
Published: April 2020

SummaryThe ongoing Cloud‐IoT (Internet of Things)–based technological advancements have revolutionized the ways in which remote patients could be monitored and provided with health care facilities. The real‐time monitoring of patient's health leads to dispensing the right medical treatment at the right time. The health professionals need to access patients' sensitive data for such monitoring, and if treated with negligence, it could also be used for malevolent objectives by the adversary. Hence, the Cloud‐IoT–based technology gains could only be conferred to the patients and health professionals, if the latter authenticate one another properly. Many authentication protocols are proposed for remote patient health care monitoring, but with limitations. Lately, Sharma and Kalra (DOI: 10.1007/s40998‐018‐0146‐5) present a remote patient‐monitoring authentication scheme based on body sensors. However, we discover that the scheme still bears many drawbacks including stolen smart card attack, session key compromise, and user impersonation attacks. In view of those limitations, we have designed an efficient authentication protocol for remote patient health monitoring that counters all the above‐mentioned drawbacks. Moreover, we prove the security features of our protocol using BAN logic‐based formal security analysis and validate the results in ProVerif automated security tool.
Patterns of chromosome 18 loss of heterozygosity in multifocal ileal neuroendocrine tumors
Authors: Zhang Zhouwei , Mäkinen Netta , Kasai Yosuke , Kim Grace E. , Diosdado Begoña , Nakakura Eric , Meyerson Matthew 
Published: April 2020

AbstractIleal neuroendocrine tumors (NETs) represent the most common neoplasm of the small intestine. Although up to 50% of patients with ileal NETs are diagnosed with multifocal disease, the mechanisms by which multifocal ileal NETs arise are not yet understood. In this study, we analyzed genome‐wide sequencing data to examine patterns of copy number variation in 40 synchronous primary ileal NETs derived from three patients. Chromosome (chr) 18 loss of heterozygosity (LOH) was the most frequent copy number alteration identified; however, not all primary tumors from the same patient had evidence of this LOH. Our data revealed three distinct patterns of chr18 allelic loss, indicating that primary tumors from the same patient can present different LOH patterns including retention of either parental allele. In conclusion, our results are consistent with the model that multifocal ileal NETs originate independently. In addition, they suggest that there is no specific germline allele on chr18 that is the target of somatic LOH.
A pilot randomized controlled trial of hearing aids to improve mood and cognition in older adults
Authors: Brewster Katharine K. , Pavlicova Martina , Stein Alexandra , Chen Mei , Chen Chen , Brown Patrick J. , Roose Steven P. , Kim Ana H. , Golub Justin S. , Brickman Adam , Galatioto Jessica , Kuhlmey Megan , Rutherford Bret R. 
Published: April 2020

ObjectivesAge‐related hearing loss (ARHL) is a prevalent condition associated with increased risk for depression and cognitive decline. This 12‐week prospective, double‐blind pilot randomized controlled trial (RCT) of hearing aids (HAs) for depressed older adults with ARHL evaluated the feasibility of a novel research design.Methods/DesignN = 13 individuals aged ≥60 years with Major Depressive Disorder or Persistent Depressive Disorder and at least mild hearing loss (pure tone average ≥ 30 dB) were randomized to receive full‐ (active) vs low‐amplification (sham) HAs added to psychiatric treatment as usual. Duration of HA use in hours/day, adverse events frequency, attrition rate, and maintenance of the study blinding were the primary outcome measures.ResultsCompliance with HAs was excellent (>9 hours/day for both groups) and rates of adverse events and drop‐outs did not differ between groups. Preliminary data demonstrated differential improvement for active vs sham HAs on hearing functioning (Hearing Handicap Inventory for the Elderly [nonparametric effect size (np‐ES) = 0.62]), depressive symptoms (Inventory for Depressive Symptomatology [np‐ES = 0.31]), cognition (Repeatable Battery for the Assessment of Neuropsychological Status Immediate Memory [np‐ES = 0.25]), and general functioning (World Health Organization Disability Assessment Schedule [np‐ES = 0.53]). Significantly greater than 50% of both groups correctly guessed their treatment assignment, indicating incomplete concealment of treatment allocation.ConclusionsThis pilot RCT for ARHL and late‐life depression was feasible to execute and showed clinical promise, but improved methods of blinding the experimental treatments are needed. Larger studies should investigate whether hearing remediation may be an effective preventative and/or therapeutic strategy for late‐life depression and cognitive decline.
An experimental investigation to consider thermal methods efficiency on oil recovery enhancement
Authors: Lu Wang , Davarpanah Afshin 
Published: April 2020

AbstractTo study the profound impact of reservoir characteristics on flow regime in two‐phase condition, the effect of saturation and capillary pressure (Pc–S) should be taken into consideration in the porous medium. The purpose of this extensive experimental investigation is to inject the foaming agent and nitrogen gas, which is produced by the foam generator after waterflooding in a fractured reservoir to select the best optimum scenario. It has been elaborated that nitrogen of lower density and lower compressibility would provide a secondary gas cap at the top of the cores which causes to mobilize more oil volume in the unswept zones. The rupturing of foam considerably influences this phenomenon in the high permeable layers that have led the oil of low permeable layers to be mobilized in the presence of nitrogen.
Low‐dose aspirin improves endometrial receptivity in the midluteal phase in unexplained recurrent pregnancy loss
Authors: Wang Tongfei , Kang Xiaomin , Zhao Aimin , He Liying , Liu Zhilan , Liu Fangsun 
Published: April 2020

AbstractObjectiveTo evaluate differences in Doppler parameters and pregnancy outcomes, if any, and to determine the predictive accuracy of such indices, as well as the effects of low‐dose aspirin (LDA) in unexplained recurrent pregnancy loss (URPL).MethodsAn observational study was conducted at Ren Ji Hospital, Shanghai, China, from May 2015 to December 2016. The endometrial thickness, and the pulsatility index (PI), resistive index (RI), and systolic‐to‐diastolic ratio (S/D) values of endometrial and uterine artery blood flow were collected. Receiver operating characteristic (ROC) curve analysis was used to analyze data from URPL patients (three or more first‐trimester spontaneous abortions with unknown etiology) and patients with normal fertility. A second ultrasonography examination was performed in URPL patients who had received daily LDA for 2 months.ResultsThere were 190 URPL patients and 35 control patients. Endometrial thickness was significantly thinner in URPL patients than control patients (P=0.005). The PI, RI, and S/D values for endometrial blood flow and the mean PI, RI, and S/D values for uterine arteries were significantly higher in URPL patients (P<0.001). The predictive accuracy of the indices mentioned above were 0.660, 0.802, 0.852, 0.837, 0.784, 0.929, and 0.929, respectively. Following LDA supplementation, URPL patients showed a significant reduction in resistance to endometrial and uterine artery blood flow (P<0.001).ConclusionURPL patients had impaired uterine perfusion. Doppler parameters are valuable in predicting women at high risk of URPL. LDA could be effective in improving endometrial receptivity.
Exploiting Augmented Intelligence in Systems Engineering and Engineered Systems
Authors: Madni Azad M. 
Published: April 2020

ABSTRACTWith AI resurgence paced by recent machine learning advances, several engineering disciplines including systems engineering turn to AI to improve system model accuracy, process flexibility, content exploration and search, and team productivity. More recently, AI has become a means to augment rather than replace human capability. This perspective alters AI's role from autonomous intelligence to augmented intelligence (AugI). Inherent in this view, recognizing AI and human together can perform certain tasks better than either could alone. This paper presents a methodological framework for effectively exploiting AugI in systems engineering and in engineered intelligent human‐machine systems.
Current progresses and trends in carbon nanomaterials‐based electrochemical and electrochemiluminescence biosensors
Authors: Adhikari Juthi , Rizwan Mohammad , Keasberry Natasha Ann , Ahmed Minhaz Uddin 
Published: April 2020

AbstarctThe enormous potential of biosensors in medical diagnostics has motivated scientists to develop newer innovative tools and advance biosensing technologies. The use of cell, organelles, nucleotides, aptamers, antibodies, affibodies, proteins, peptides, molecules, and printed polymers, merged with nanotechnology, offers excellent tools to prepare highly sensitive and advanced biosensors. Therefore, the current decade has witnessed a rapid surge in the fabrication of different nanomaterial‐based biosensors. Among them, carbon nanomaterials (CNMs) have emerged highly attractive in the fabrication of both electrochemical and electrochemiluminescence (ECL) biosensors. On one hand, CNMs bear prominent electrical conductivity, large surface area to immobilize adequate amount of biomolecules, an enhanced loading capacity, improved biocompatibility, and active site for electrochemical reaction. Additionally, CNMs could be chemically modified for the covalent coupling with the biomolecules. On the other hand, both electrochemical and ECL biosensors allow for cost‐effective, rapid, and real‐time detection with excellent sensitivity and selectivity, with the capability of integrating different biomolecules and CNMs on the same chip. However, currently there is not a single review, which includes CNM‐based electrochemical and ECL biosensors' current progress and trends. Therefore, this review intends to survey the current progress and future trends in CNM‐based electrochemical and ECL biosensors.