bluuebunny/crossref_metadata_2025_split huggingface dataset:
Escalating Value of Idle Marginal Offshore Brown Field through Collaboration and Technology in South East Sumatera, Indonesia
Authors: Waskito Lucky Bagus , Gunawan Heri , Nugroho Pranowo , Luthfan Mochammad 
Published: October 2019

Abstract
A collaborative effort between subsurface, operation and commercial team has successfully escalated the value of idle marginal offshore brown field in south east Sumatera, Indonesia. Over the past several years Lidya field was idle due to wellbore and facility problem, big investment value are needed to reactivate Lidya field and it creates hesitation in management decision, also there is a security issue to be considered. This paper describes the methodology applied in evaluating all aspects considered to mitigate the investment risk, escalating economical value and to ensure all parameters perform as expected.
The evaluation method divided into three major parts, the first part starts from subsurface study that involving geophysical processing, geologist re-interpretation, and reservoir engineering analysis, one of the most important factors to be taken into account is the necessity of a good understanding of the reservoir in order to increase the possibility of success. The second part is operation evaluation, it captures production engineering analysis from well integrity assessment to artificial lift selection, facilities observation from pipeline assessment to platform refurbishment option and also designing new security system to prevent cable thievery. The third part is the most crucial part to justify the value of Lidya marginal field reactivation project, challenges in this part also interesting, because production sharing contract term has changed from Cost Recovery to Gross Split mechanism, several cases was observed by commercial team to find the very best case with the least risk that might occur and affect the investment.
As a result, the value of Lidya idle marginal field was escalated. It can be quantifed from oil rate that increase from 150 BOPD for the last five years before it went idle to 700 BOPD for full cycle project. Economic side also appealing, observation multiple cases led to optimum case that can give total contractor net cash flow at almost 19Million USD in new fiscal term Gross Split mechanism, this number is 4 times higher than Cost Recovery mechanism for contractor profitability.
Developing marginal offshore mature asset is a risky business, especially considering high volatility in oil prices. Collaboration and technology are vital to escalating the value and achieving higher recovery factors. Application of the multidisciplinary methods was considered as an appropriate way to approach and manage a complex marginal mature field redevelopment.
Analysis Method of Cement Sheath Damage Zone After Perforation
Authors: Yan Yan , Guan Zhichuan , Yan Weijun , Wang Hongtu 
Published: October 2019

Abstract
The combined technology of perforation and hydraulic fracturing has been the main development method for unconventional oil and gas to date. However, perforation can cause crack damage to cement sheath or de-bonding of the cement interfaces, resulting in fluid channeling during hydraulic fracturing. From an operational perspective, it is thus critical to be able to characterize the degree and range of cement sheath damage after perforation. To achieve the objective, a numerical method of perforation is set up based on the ALE (Arbitrary Lagrange-Euler) algorithm in LS-DYNA software. The numerical results are verified by the ring target simulation test. The cement-interface damage zone shapes like a saddle after perforation, and there is a narrow range of damage around the perforation tunnel. The damage zone is minimized with the enhancement of cement compressive strength but conversely with shear modulus. Cements with lower shear modulus and higher compressive strength should be selected during well cementing for reducing cement sheath perforation damage. Additionally, a shaped charge with smaller liner diameter is more effective in enhancing the seal integrity during hydraulic fracturing.
Multiscale Digital Rock Modelling for Reservoir Simulation
Authors: Reshetova Galina , Cheverda Vladimir , Lisitsa Vadim , Khachkova Tatyana 
Published: October 2019

Abstract
We present analysis of sandstone micro-CT scans obtained with different resolution. We show that use of fine resolution (about 1 micrometer per voxel) do not provide valuable information about the core structure and for the pore surface analysis and makes the sample nonrepresentative even for porosity estimation. Scans with resolution of 3–5 μm per voxel allow to get statistically reliable estimates of the reciprocal pore-to-core distribution, topological properties of the pore space and transport properties of the sample. Using this information one can reconstruct the macroscopic model of poroelastic media.
Simplify Bypass Pig Speed Calculation Using Probabilistic Method
Authors: Abdul Samad Khairul Anwar , M Nadzeri M Shahrustami , Liew Patricia Fung , Lau Kheng Hoong , Mat Isa Badlishah , Abdul Rasyid Ramlah , M Shahrin M Hafizuddin 
Published: October 2019

Abstract
One of the challenges in pipeline operational pigging in multiphase pipeline is high Pig Generated Volume (PGV) liquid slug that arrives at the end of the pipeline receiving system. This causes process upset at the receiving plant, which in turn causes production deferment each time pigging activity is performed. Introduction of bypass pig for cleaning activity is one of the best solutions to manage the arriving liquid slug at the receiving end to allow ample time for the plant to control the arriving slug and evacuate liquid without initiating a process upset. Usually to design the bypass pig would require specific hydraulic pipeline simulation with expertise and experience personnel to perform the assessment. Meanwhile, pipeline operator are also dealing with a fluctuating gas flowrate, temperature and pressure during pigging operation which effect the selection of bypass pig design. There are records of bypass pig stalled which happened as a result of not considering the variation of these input variables. This paper elaborates alternative calculation methodology using Monte Carlo probabilistic method to assess input variables via a spreadsheet, prior to determining the final bypass pig design.
Groot (2015) provide a detailed explanation on bypass pig calculation using mass balanced approach to determine the bypass pig speed based on specified bypass opening. To determine the bypass pig speed, the gas velocity through bypass opening is subtracted from gas mixture velocity. For this case study, bypass pig with disc type is used. The minimum and maximum value for input parameter is used in the calculation using RANDOM functions in the spreadsheet. The calculation is repeated for 10,000 iterations to get the different result based on random range of operating parameter that has been set earlier. The calculation boundary is determined whereby for this case is the bypass pig speed. Result which fall within the boundary will determine the success rate of the bypass pig design, without pig stall or over speed.
Using Monte Carlo probabilistic method, the optimum bypass pig opening could be determined to avoid over speed or pig stall. Probabilistic method enables the user to analyze using descriptive statistic ie. minimum, maximum or average pig speed from various conditions. In conclusion, probabilistic method has significantly help the user to assess the bypass pig speed with fluctuation of operating parameters using simple spreadsheet.
Asset Wide Optimisation: How a Real-Time Integrated Production System Model for Optimisation Keeps the Lights on in Brunei
Authors: Abdullah Zulfikri , Briers Jan , Jamil Mariana , Sahu Sambit , Tan Jun Xian , Zainal-Abidin Hadini 
Published: October 2019

Abstract
Brunei Shell Petroleum (BSP) has a complex production gathering network that comprises of multiple onshore and offshore Assets. Gas and oil is produced under different pressure regimes, and with varying compositions. The production from each asset can be routed in multiple ways to different customers, each with their own compositional requirements. Crude oil and gas is routed to Brunei Liquified Natural Gas (BLNG) and Seria Crude Oil terminal (SCOT) for further processing before export to external customers. Apart from export, other customers include BMC (Brunei Methanol Company), Brunei Shell Refinery (BSR) and Department of Electrical Services (DES), fueling Brunei's vehicles, homes and local industries.
Currently this complex production network is managed by a dedicated Operations Control Centre (OCC). The central OCC team coordinates, monitors and controls the hydrocarbon activities to meet customers' quality and quantities demand by engaging with the 4 individual Asset Operation teams, as well as customers, to optimize production at the Pan-BSP system level.
With the introduction of the Integrated Production Monitoring and Optimisation System (IPMOS) tool, the Pan-BSP production optimisation can be automated, in real-time. The IPMOS tool performs a high-level production optimisation built on top of existing real-time well production surveillance models, and it dynamically adjusts the system capacity in the event of upsets. In this way, the tool provides day to day advisory of production optimisation during both normal operations as well as during different production upset scenarios, and it also eliminates the need for OCC team to maintain multiple MS Excel sheets/macros to cater for those scenarios. This is a step forward in production system optimisation through digitalisation.
High Molecular Weight Organic Scale Near Wellbore Improved Oil Recovery
Authors: Mohd Hatta Siti Aishah , Masngot Ainul Azuan , Sidek Sulaiman , M Yusuf M Hafizi , Tan Kok Liang , Goh Kellen Hui , Tang Catherine Ye , Bernard Caesarsokate , Mawardi M Hizbullah , Hamzah Haziqah , Mohd Jeffry Suzanna Juyanty , Riyanto Latief , Samaile Eddy , Ahmat Kamis Azman , Ahnap Muhammad Al-Siediq , Ramli Zaizul Kamal , See Chun Hwa 
Published: October 2019

Abstract
Oil production from the field begin with the first oil in January 2003. Unfortunately, the wells produced viscous emulsion which caused the production decline rapidly. Further analysis of the production data showed that the decline in production over a long period of time is very consistent with organic deposition at or near the perforation interval.
Over the years, several analyses and production enhancement efforts including chemical and mechanical treatments have been attempted with minimal success. The damaging mechanism was determined to be caused by rare High Molecular Weight Organic Deposit (HMWOD) that have caused a significant pressure drop in the tubing, which consequently restrict oil production and tested to only disperse at above 90°C. It was suspected that the deposit was a naturally-occurring component of the crude oil itself, separating from the bulk of the crude as a consequence of the fluids movement towards the wellbore and the consequent drop in fluid pressure.
An eco-friendly nano-fluid was developed and pilot treatment conducted in February 2014, which successfully rejuvenated the well back to production. Subsequent treatment was conducted in early 2018 on the same well and later replicated on another well as part of technology maturation process. This paper incorporates laboratory tests conducted to customize the nano-fluid, engineering approach on the treatment volume, simulation analysis on treatment schedules, treatment procedure as guidance for offshore personnel and actual field result of the treatments.
Remedial treatment for near wellbore HMWOD using novel nano-fluid has successfully revived the wells back to production. Further development and replication would open-up bigger opportunities to unlock potential of wells with similar organic deposit issue throughout PETRONAS' operation.
Diazepam and ethanol differently modulate neuronal activity in organotypic cortical cultures
Authors: Kreuzer Matthias , García Paul S , Brucklacher-Waldert Verena , Claasen Rebecca , Schneider Gerhard , Antkowiak Bernd , Drexler Berthold 
Published: October 2019

Abstract
Background: The pharmacodynamic results of diazepam and ethanol administration are similar, in that each can mediate amnestic, sedative-hypnotic effects. Although each of these molecules effectively reduce the activity of central neurons, diazepam does so through modulation of a more specific set of receptor targets (GABAA receptors containing a g-subunit), while alcohol is less selective in its receptor bioactivity. Our investigation focuses on divergent actions of diazepam and ethanol on the firing patterns of cultured cortical neurons.
Method: We used electrophysiological recordings from organotypic slice cultures derived from Sprague-Dawley rat neocortex. We exposed these cultures to either diazepam (15 and 30 µM, n = 7) or ethanol (30 and 60 mM, n = 11) and recorded the electrical activity at baseline and experimental conditions. For analysis, we extracted the episodes of spontaneous activity, i.e., cortical up-states. After separation of action potential and local field potential (LFP) activity, we looked at differences in the number of action potentials, in the spectral power of the LFP, as well as in the coupling between action potential and LFP phase.
Results: While both substances seem to decrease neocortical action potential firing in a not significantly different (p=0.659, Mann-Whitney U) fashion, diazepam increases the spectral power of the up-state without significantly impacting the spectral composition, whereas ethanol does not significantly change the spectral power but the oscillatory architecture of the up-state as revealed by the Friedman test with Bonferroni correction (p<0.05). Further, the action potential to LFP-phase coupling reveals a synchronizing effect of diazepam for a wide frequency range and a narrow-band de-synchronizing effect for ethanol (p<0.05, Kolmogorov-Smirnov test).
Conclusion: Diazepam and ethanol, induce specific patterns of network depressant actions. Diazepam induces cortical network inhibition and increased synchronicity via gamma subunit containing GABAA receptors. Ethanol also induces cortical network inhibition, but without an increase in synchronicity via a wider span of molecular targets.
Lapatinib sensitivity in nasopharyngeal carcinoma is modulated by SIRT2-mediated FOXO3 deacetylation
Authors: Aimjongjun Sathid , Mahmud Zimam , Jiramongkol Yannasittha , Alasiri Glowi , Yao Shang , Yague Ernesto , Janvilisri Tavan , Lam Eric W.-F. 
Published: October 2019

Abstract
Background
Chemoresistance is an obstacle to the successful treatment of nasopharyngeal carcinoma (NPC). Lapatinib is a targeted tyrosine kinase inhibitor therapeutic drug also used to treat NPC, but high doses are often required to achieve a result. To investigate the mechanism for the development of Lapatinib resistance, we characterised a number of NPC cell lines to determine the role of FOXO3 and sirtuins in regulating NPC resistance.

Methods
Sulforhodamine B (SRB) assays, Clonogenic assays, Protein extraction, quantification and western blotting, RT qPCR, Co-immunoprecipitation assay

Results
To explore novel treatment strategies, we first characterized the Lapatinib-sensitivity of a panel of NPC cell lines by SRB and clonogenic cytotoxic assays and found that the metastatic NPC (C666-1 and 5-8F) cells are highly resistant whereas the poorly metastatic lines (6-10B, TW01 and HK-1)are sensitive to Lapatinib. Western blot analysis of the Lapatinib-sensitive 6-10Band resistant 5-8FNPC cells showed that the expression of phosphorylated/inactive FOXO3 (P-FOXO3;T32), its target FOXM1 and its regulator SIRT2 correlate negatively with Lapatinib response and sensitivity, suggesting that SIRT2 mediates FOXO3 deacetylation to promote Lapatinib resistance. In agreement, clonogenic cytotoxic assays using wild-type and foxo1/3/4 −/− mouse embryonic fibroblasts (MEFs) showed that FOXO1/3/4-deletion significantly attenuates Lapatinib-induced cytotoxicity, confirming that FOXO proteins are essential for mediating Lapatinib response. SRB cell viability assays using chemical SIRT inhibitors (i.e. sirtinol, Ex527, AGK2 and AK1) revealed that all SIRT inhibitors can reduce NPC cell viability, but only the SIRT2-specific inhibitors AK1 and AGK2 further enhance the Lapatinib cytotoxicity. Consistently, clonogenic assays demonstrated that the SIRT2 inhibitors AK1 and AGK2 as well as SIRT2-knockdown increase Lapatinib cytotoxicity further in both the sensitive and resistant NPC cells. Co-immunoprecipitation studies showed that besides Lapatinib treatment, SIRT2-pharmaceutical inhibition and silencing also led to an increase in FOXO3 acetylation. Importantly, SIRT2 inhibition and depletion further enhanced Lapatinib-mediated FOXO3-acetylation in NPC cells.

Conclusion
Collectively, our results suggest the involvement of SIRT2-mediated FOXO3 deacetylation in Lapatinib response and sensitivity, and that SIRT2 can specifically antagonise the cytotoxicity of Lapatinib through mediating FOXO3 deacetylation in both sensitive and resistant NPC cells.
Pregnancy outcomes of Q fever : Prospective follow-up study on Reunion Island
Authors: Mboussou Yoan , Jaubert Julien , Larrieu Sophie , Atiana Laura , Naze Florence , Folio Christine , Randrianaivo Hanitra , Bertolotti Antoine , Picot Sandrine , Robillard Pierre-Yves , Boukerrou Malik , Gérardin Patrick 
Published: October 2019

Abstract
Background Q fever has been associated with perinatal complications. We conducted a prospective follow-up study to assess both the incidence of adverse pregnancy outcomes (APOs) associated with Coxiella burnetii infection and the contribution of Q fever to APOs.
Methods Between May 1 and October 31, 2013, within the regional perinatal health care centre of Saint Pierre, Reunion island, we investigated unexplained miscarriages, stillbirths, preterm births or small-for-gestational age children. Seropositivity for C. burnetii antibodies was defined using indirect immunofluorescence for a phase 2 IgG titre ≥1:64. Acute Q fever was defined for a high phase 2 IgG titre ≥1:256 (compatible with recent or active infection) or the detection of C. burnetii genome in miscarriage products and placentas. Incidence rate ratios (IRR) for Q fever related APOs (taken as a composite outcome or individually) were assessed using Poisson regression models for dichotomous outcomes controlling major confounders.
Results Over a 6-month period, 179 pregnant women suspected or diagnosed with an APO were investigated for Q fever, of whom 118 met the definition for an APO. Of these, 19 were seropositive and 10 presented a profile indicative of an acute infection. For three women with an acute Q fever, the chronology between the onset of infection, the APO (2 miscarriages, 1 preterm birth) and the seroconversion suggested causality in the pathogenesis. The cumulative incidence of Q fever related APOs was estimated between 2.2‰ and 5.2‰, whether causality was required or not. Both C. burnetii exposure and acute Q fever were independently associated with APOs (IRR 1.55, 95% CI 1.31-1.84; IRR 1.47, 95% CI 1.15-1.89, respectively).
Conclusions In the endemic context of Reunion island, acute Q fever may lead to APOs. To limit the burden of Q fever on reproduction, pregnant women should be kept away from farms and avoid direct contact with ruminants.
Susceptibility of BAFF-var allele carriers to severe SLE with occurrence of lupus nephritis
Authors: Friebus-Kardash Justa , Trendelenburg Marten , Eisenberger Ute , Ribi Camillo , Chizzolini Carlo , Huynh-Do Uyen , Lang Karl Sebastian , Wilde Benjamin , Kribben Andreas , Witzke Oliver , Dolff Sebastian , Hardt Cornelia 
Published: October 2019

Abstract
Background: Dysregulation of the B-cell activating factor (BAFF) system is involved in the pathogenesis of systemic lupus erythematosus (SLE). Increased serum concentrations of BAFF are related to lupus nephritis and disease activity among SLE patients. Recently, a variant of the BAFF-encoding gene, BAFF-var, was identified to be associated with autoimmune diseases, in particular SLE, and to promote the production of soluble BAFF. The present study aimed to assess the prevalence of BAFF-var in a cohort of 195 SLE patients and to analyze the association of the BAFF-var genotype (TNSF13B) with various manifestations of SLE.
Methods: A cohort of 195 SLE patients from Central Europe, including 153 patients from the Swiss SLE Cohort Study and 42 patients from the University Hospital Essen, Germany, underwent genotyping for detection of BAFF-var allele.
Results: Of the 195 patients, 18 (9.2%) tested positive for BAFF-var variant according to the minor allele frequency of 4.6%. The presence of BAFF-var was associated with the occurrence of lupus nephritis (p=0.038) (p=0.03 and p=0.003). Among various organ manifestations of SLE, the presence of BAFF-var was associated with the occurrence of lupus nephritis (p=0.038; odds ratio [OR], 2.4; 95% confidence interval [CI], 0.89-6.34) and renal activity markers such as proteinuria and hematuria (p=0.03; OR, 2.4; 95% CI, 0.9-6.4 for proteinuria; p=0.003; OR, 3.9; 95% CI, 1.43-10.76 for hematuria). SLE patients carrying the BAFF-var allele exhibited increased disease activity at study entry, as determined by the physician's global assessment (PGA: p=0.002; OR, 4.8; 95% CI, 1.54-14.93) and the SLE Disease Activity Index (p=0.012; OR, 3.5; 95% CI, 1.12-11.18). Consistent with that, the percentage of patients treated with immunosuppressive agents at study entry was higher among those carrying the BAFF-var allele than among those tested negative for BAFF-var (p=0.006; OR, 3.7; 95% CI, 1.27-10.84).
Conclusions: Our results indicate an association between the BAFF-var genotype and increased severity of SLE. Determining the BAFF-var status of SLE patients may improve the risk stratification of patients for whom the development of lupus nephritis is more likely and thus may be helpful in the follow-up care and treatment of SLE patients.
Validation and evaluation of a common biomarker in human cancers sera protein detected by a monoclonal antibody UNIVMab
Authors: Dandi Manjunath , Kumaraswamy Sunil B , V Shashidhara A , Appaiah Hitesh N , Thomas Anil , BANERJEE SHIBDAS 
Published: October 2019

Abstract
Abstract
Objective:
Management and diagnosis of multiple human cancers remain a challenge and search for a common biomarker are still debatable. We described a method and evaluated the use of monoclonal antibody UNIVMab, to detect the protein (H11) as a common biomarker for all cancer irrespective of grade and origin . H11 protein identified as a unique Hyaluronan binding protein not detected earlier. We applied this test both with ELISA, Western blot, fractionated in anion exchange, cibacron gel exclusion, b-Hyaluronan interaction and HA-Oligo competition from various grades of Human cancers sera and processed for the detection of hyaluronan binding protein H11, reacted with Monoclonal antibody UNIVMab and with b-HA.
Results:
Studies from ELISA, Western blot and b-Hyaluronan interactions showed a definitive positive over-expression of UNIVMab reacted H11 antigen in all fortyfive cancer sera compared to normal sera and can be used as a common biomarker. We believe, UNIVMab detected H11 antigen, a unique hyaluronan binding protein, is a common biomarker for all cancer sera.
Keywords:
ELISA, Western blot, Hyaluronic acid binding protein, H11 (sera antigen), UNIVMab. Common Biomarker, Cancers Sera