bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Probabilistic Design Reuse Index for Engineering Designs
Authors: Vasantha Gokula , Corney Jonathan , Stuart Struan , Sherlock Andrew , Quigley John , Purves David 
Published: February 2020

AbstractMany companies offer a range of related products that are constructed using similar components and processes. This enables them to meet customer expectations of product variety while minimizing the overheads (e.g., development and manufacturing costs). To support the management of product variety several indices have been proposed in the literature that measure the degree to which component use is standardized across products within the same product family. However, the derivation of some of these statistics can be laborious to calculate due to the effort required to assemble the necessary information. In this paper, we develop an index more suited to the automated data-mining of a company’s product portfolio, which is derived from the Kullback–Leibler divergence. The new measure provides an easily computed probabilistic measure that can be used to characterize the degree of component reuse within a single product, across a family of products, and at the individual component family level. To illustrate their applications, the indices and several existing measures are calculated for two contrasting product types; using the non-differentiating components of two flat-pack furniture ranges and the components of a range of bicycles.
Exploring geographic variation of and influencing factors for utilization of four diabetes management measures in Swiss population using claims data
Authors: Wei Wenjia , Gruebner Oliver , von Wyl Viktor , Dressel Holger , Ulyte Agne , Brüngger Beat , Blozik Eva , Bähler Caroline , Braun Julia , Schwenkglenks Matthias 
Published: February 2020

IntroductionFour strongly recommended diabetes management measures are biannual glycated hemoglobin (HbA1c) testing, annual eye examination, kidney function examination, and low-density lipoprotein (LDL) testing in patients below 75 years. We aimed to describe regional variation in the utilization of the four measures across small regions in Switzerland and to explore potential influencing factors.Research design and methodsWe conducted a cross-sectional study of adult patients with drug-treated diabetes in 2014 using claims data. Four binary outcomes represented adherence to the recommendations. Possible influencing factors included sociodemographics, health insurance preferences, and clinical characteristics. We performed multilevel modeling with Medstat regions as the higher level. We calculated the median odds ratio (MOR) and checked spatial autocorrelation in region level residuals using Moran’s I statistic. When significant, we further conducted spatial multilevel modeling.ResultsOf 49 198 patients with diabetes (33 957 below 75 years), 69.6% had biannual HbA1c testing, 44.3% each had annual eye examination and kidney function examination, and 55.5% of the patients below 75 years had annual LDL testing. The effects of health insurance preferences were substantial and consistent. Having any supplementary insurance (ORs across measures were between 1.08 and 1.28), having supplementary hospital care insurance (1.08–1.30), having chosen a lower deductible level (eg, SFr2500 compared with SFr300: 0.57–0.69), and having chosen a managed care model (1.04–1.17) were positively associated with recommendations adherence. The MORs (1.27–1.33) showed only moderate unexplained variation, and we observed inconsistent spatial patterns of unexplained variation across the four measures.ConclusionOur findings indicate that the uptake of strongly recommended measures in diabetes management could possibly be optimized by providing further incentives to patients and care providers through insurance scheme design. The absence of marked regional variation implies limited potential for improvement by targeted regional intervention, while provider-specific promotion may be more impactful.
Using internet search data to explore the global public concerns in ankylosing spondylitis
Authors: Mei Yong-Jun , Mao Yan-Mei , Cao Fan , Wang Tao , Li Zhi-Jun 
Published: February 2020

ABSTRACTObjectiveThis study explored the changes of global public interest in internet search of ankylosing spondylitis (AS) based on Google Trends (GT) data, in order to reflect the characteristics of AS itself.MethodsGT was used to obtain the search popularity scores of the term ’AS’ on a global scale, between January 2004 and December 2018, under the ’health’ classification. Based on the global search data of AS provided by GT, the cosinor analysis was used to test whether there was seasonality in AS.ResultsIn general, AS related search volume demonstrated a decreasing trend from January 2004 to December 2014 and then remain stable from January 2015 to December 2018. No obvious seasonal variations were detected in AS related search volume (amplitude=1.54; phase: month=3.9; low point: month=9.9; p&gt;0.025), which peaked in April and bottomed out in October. The top 17 rising topics were adalimumab, spondylolisthesis, Morbus, Vladimir Mikhailovich Bekhterev, autoimmune disease, rheumatoid arthritis, ankylosis, HLA- B27 positive, Crohn’s disease, rheumatology, spondylosis, arthritis, uveitis, rheumatism, sacroiliac, psoriatic arthritis and spondylitis.ConclusionsGlobally, there is no significant seasonal variation in GT for AS. The top fast-growing topics related to AS may be beneficial for doctors to provide targeted health education of the disease to patients and their families.
Glial TIM-3 Modulates Immune Responses in the Brain Tumor Microenvironment
Authors: Kim Hyung-Seok , Chang Chi Young , Yoon Hee Jung , Kim Ki Sun , Koh Han Seok , Kim Sang Soo , Lee Sang-Jin , Kane Lawrence P. , Park Eun Jung 
Published: February 2020

Abstract

T-cell immunoglobulin and mucin domain–containing molecule 3 (TIM-3), a potential immunotherapeutic target for cancer, has been shown to display diverse characteristics in a context-dependent manner. Thus, it would be useful to delineate the precise functional features of TIM-3 in a given situation. Here, we report that glial TIM-3 shows distinctive properties in the brain tumor microenvironment. TIM-3 was expressed on both growing tumor cells and their surrounding cells including glia and T cells in an orthotopic mouse glioma model. The expression pattern of TIM-3 was distinct from those of other immune checkpoint molecules in tumor-exposed and tumor-infiltrating glia. Comparison of cells from tumor-bearing and contralateral hemispheres of a glioma model showed that TIM-3 expression was lower in tumor-infiltrating CD11b+CD45mid glial cells but higher in tumor-infiltrating CD8+ T cells. In TIM-3 mutant mice with intracellular signaling defects and Cre-inducible TIM-3 mice, TIM-3 affected the expression of several immune-associated molecules including iNOS and PD-L1 in primary glia-exposed conditioned media (CM) from brain tumors. Further, TIM-3 was cross-regulated by TLR2, but not by TLR4, in brain tumor CM- or Pam3CSK4-exposed glia. In addition, following exposure to tumor CM, IFNγ production was lower in T cells cocultured with TIM-3–defective glia than with normal glia. Collectively, these findings suggest that glial TIM-3 actively and distinctively responds to brain tumor, and plays specific intracellular and intercellular immunoregulatory roles that might be different from TIM-3 on T cells in the brain tumor microenvironment.

Significance:
TIM-3 is typically thought of as a T-cell checkpoint receptor. This study demonstrates a role for TIM-3 in mediating myeloid cell responses in glioblastoma.
Comprehensive Diagnostic Evaluation of Cardiovascular Physiology in Patients With Pulmonary Vascular Disease
Authors: Tang W. H. Wilson , Wilcox Jennifer D. , Jacob Miriam S. , Rosenzweig Erika B. , Borlaug Barry A. , Frantz Robert P. , Hassoun Paul M. , Hemnes Anna R. , Hill Nicholas S. , Horn Evelyn M. , Singh Harsimran S. , Systrom David M. , Tedford Ryan J. , Vanderpool Rebecca R. , Waxman Aaron B. , Xiao Lei , Leopold Jane A. , Rischard Franz P. ,   the PVDOMICS Study Group
Published: February 2020

Background:
Invasive hemodynamic evaluation through right heart catheterization plays an essential role in the diagnosis, categorization, and risk stratification of patients with pulmonary hypertension.

Methods:
Subjects enrolled in the PVDOMICS (Redefining Pulmonary Hypertension through Pulmonary Vascular Disease Phenomics) program undergo an extensive invasive hemodynamic evaluation that includes repeated measurements at rest and during several provocative physiological challenges. It is a National Institutes of Health/National Heart, Lung, and Blood Institute initiative to reclassify pulmonary hypertension groups based on clustered phenotypic and phenomic characteristics. At a subset of centers, participants also undergo an invasive cardiopulmonary exercise test to assess changes in hemodynamics and gas exchange during exercise.

Conclusions:
When coupled with other physiological testing and blood -omic analyses involved in the PVDOMICS study, the comprehensive right heart catheterization protocol described here holds promise to clarify the diagnosis and clustering of pulmonary hypertension patients into cohorts beyond the traditional 5 World Symposium on Pulmonary Hypertension groups. This article will describe the methods applied for invasive hemodynamic characterization in the PVDOMICS program.

Registration:

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT02980887.
Estimating Rain Microphysical Characteristics Using S-Band Dual-Polarization Radar in South Korea
Authors: Kim Hae-Lim , Jung Sung-Hwa , Jang Kun-Il 
Published: February 2020

AbstractRaindrop size distribution (DSD) observed using a disdrometer can be represented by a constrained-gamma (C-G) DSD model based on the empirical relationship between shape (µ) and slope (Λ). The C-G DSD model can be used to retrieve DSDs and rain microphysical parameters from dual-polarization radar measurements of reflectivity (ZH) and differential reflectivity (ZDR). This study presents a newµ–Λ relationship to characterize rain microphysics in South Korea using a two-dimensional video disdrometer (2DVD) and Yong-in S-band dual-polarization radar. To minimize sampling errors from the 2DVD and radar measurements, measured size distributions are truncated by particle size and velocity-based filtering and compared with rain gauge measurement. The calibration biases of radarZHandZDRwere calculated using the self-consistency constraint and vertical pointing measurements. The derivedµ–Λ relationship was verified using the mass-weighted mean diameter (Dm) and standard deviation of the size distribution (σm), calculated from the 2DVD, for comparison with existingµ–Λ relationships for Florida and Oklahoma. TheDm–σmrelationship derived from the 2DVD corresponded well with theµ–Λ relationship. Theµ–Λ relationship derived for the Korean Peninsula was similar to Florida, and both generally had largerµvalues than Oklahoma for the same Λ. The derivedµ–Λ relationship was applied to retrieve DSD parameters from polarimetric radar data, and the retrieved DSDs and derived physical parameters were evaluated and compared with the 2DVD measurements. The polarization radar-based C-G DSD model characterized rain microphysics more accurately than the exponential DSD model. The C-G DSD model based on the newly derivedµ–Λ relationship performed the best at retrieving rain microphysical parameters.
Combination of plasma exchange and haemofiltration for treating thrombotic microangiopathy in children
Authors: Huang Jun , Chen Guangming , Ma Liqiang , Tan Ting 
Published: February 2020

Objective To investigate the therapeutic effects of a combination of plasma exchange (PE) and haemofiltration (HF) for the treatment for paediatric patients with severe thrombotic microangiopathy (TMA). Methods This retrospective study analysed data from paediatric patients who were diagnosed with severe TMA and managed with either supportive therapy and additional PE and HF (PE + HF group) or supportive therapy alone (control group). Demographic and clinical characteristics, haemopurification and blood parameters and survival of the patients were compared between the two groups. Results This study enrolled 32 patients: PE + HF group ( n = 15) and control group ( n = 17). There were no significant differences between the two groups at baseline, including specific features for differentiating the two categories of TMA. The median time between onset and recovery, defined by the markers of platelet count, lactate dehydrogenase, blood urine nitrogen and hospital stay, were all significantly longer in the control group compared with the PE + HF group. Kaplan–Meier curve analysis demonstrated that the cumulative survival rate was significantly higher in the PE + HF group compared with the control group. Conclusion The combination of PE and HF could be considered as one of the treatment choices for TMA.
Autologous platelet-rich plasma therapy for refractory pain after low-grade medial collateral ligament injury
Authors: Zou Guoyou , Zheng Minqian , Chen Wang , He Xiao , Cang Dingwei 
Published: February 2020

Objective This study was performed to explore the effect of intra-articular injection of autologous platelet-rich plasma (PRP) on refractory pain after low-grade medial collateral ligament (MCL) injury. Methods In total, 52 patients with refractory pain after low-grade knee MCL injury were treated by intra-articular injection of autologous PRP. Every patient received a 5-mL intra-articular injection of autologous PRP once weekly for 3 weeks. All patients were evaluated by the International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Form score before treatment and 1, 3, and 6 months after treatment. Magnetic resonance imaging of the knee was performed to observe the healing of the MCL injury 6 months after treatment. Results After one injection, the patients’ pain was greatly decreased and they stopped taking nonsteroidal anti-inflammatory drugs. The IKDC Subjective Knee Evaluation Form scores were significantly better after than before treatment; however, there were no significant differences among the various post-treatment time points. Magnetic resonance imaging showed that the low-grade MCL injury had completely healed, and no edema was present around the MCL. Conclusions Intra-articular injection of autologous PRP is an effective treatment for refractory pain after low-grade MCL injury.
Relationship between hypertension and geographic altitude: a cross-sectional survey among residents in Tibet
Authors: Song Ci , Chongsuvivatwong Virasakdi , Zhu Luo Bu Ou , Ji De , Sang Zhuo Ma Ba , Sriplung Hutcha 
Published: February 2020

Objective This study aimed to assess the prevalence of hypertension (HT) among individuals living at different altitudes in Tibet. Methods We conducted a stratified cluster survey among 1,631 participants in Tibet living in areas at three different altitudes. Results Mean systolic and diastolic blood pressure and body mass index (BMI) values were highest at the lowest altitudes. After adjusting for age and sex, the prevalence of HT at low, medium, and high altitudes was 40.6%, 32.5%, and 20.4%, respectively. The prevalence of HT decreased with increasing altitude and increased with increasing age and BMI value. Conclusion Increasing altitude tended to decrease BMI levels, and as a consequence, the prevalence of HT was reduced. National policies and guidelines for HT in Tibet should focus on this relationship.
Evaluation of Thyroid Ultrasound Report Quality and Assessing Effect of Adherence to Risk Stratification Criteria on Referral for Thyroid Nodule Biopsy
Authors: Thejeel Bashiar , Rahimi Behruz , Seidler Michael , Al-Agha Rany , Fung Christopher 
Published: February 2020

Purpose: This study aims to evaluate the quality of diagnostic thyroid ultrasound reports and determine the impact of consistent adherence to 2015 American Thyroid Association (ATA) and 2017 American College of Radiology (ACR) Thyroid Imaging Reporting and Data System (TI-RADS) on reducing unnecessary referrals for thyroid nodule biopsy. Materials and Methods: Reports from 291 referrals for thyroid nodule biopsy were included for retrospective report evaluation (males: 42; mean age: 56) according to 2015 ATA and ACR TI-RADS lexicon. Cytology results were collected for each patient. Two radiologists blinded to cytology results independently, retrospectively reviewed imaging of the referrals, and rescored them according to 2015 ATA and 2017 ACR TI-RADS risk stratification systems. Statistical analysis was completed using chi-square analysis and calculation of κ statistic for interobserver variability. Results: No report completely addressed all features associated with malignancy. Over half of the reports did not include descriptors on echogenicity, shape, margin, or echogenic foci. In all, 9.3% of biopsies showed malignant histology. Rescoring of referrals demonstrated decrease in biopsy referrals by 55% as per 2017 ACR TI-RADS and 14% as per 2015 ATA ( P < .0001). There was no impact on detection of malignancy with adherence to ATA or ACR criteria and less interobserver variability with application of 2017 ACR TI-RADS compared to 2015 ATA. Conclusion: Thyroid ultrasound report quality was found variable with respect to nodule description. Reports recommended biopsy based on nodule size with no detailed description of other imaging features. Adherence to risk stratification system would have resulted in significant reduction in the number of unnecessary biopsy referrals.
Experience in an Urban Level 1 Trauma Center With Tranexamic Acid in Pediatric Trauma: A Retrospective Chart Review
Authors: Thomson Julie M. , Huynh Hanh H. , Drone Holly M. , Jantzer Jessica L. , Tsai Albert K. , Jancik Jon T. 
Published: February 2020

Background: Evidence for tranexamic acid (TXA) in the pharmacologic management of trauma is largely derived from data in adults. Guidance on the use of TXA in pediatric patients comes from studies evaluating its use in cardiac and orthopedic surgery. There is minimal data describing TXA safety and efficacy in pediatric trauma. The purpose of this study is to describe the use of TXA in the management of pediatric trauma and to evaluate its efficacy and safety end points. Methods: This retrospective, observational analysis of pediatric trauma admissions at Hennepin County Medical Center from August 2011 to March 2019 compares patients who did and did not receive TXA. The primary end point is survival to hospital discharge. Secondary end points include surgical intervention, transfusion requirements, length of stay, thrombosis, and TXA dose administered. Results: There were 48 patients aged ≤16 years identified for inclusion using a massive transfusion protocol order. Twenty-nine (60%) patients received TXA. Baseline characteristics and results are presented as median (interquartile range) unless otherwise specified, with statistical significance defined as P < .05. Patients receiving TXA were more likely to be older, but there was no difference in injury type or Injury Severity Score at baseline. There was no difference in survival to discharge or thrombosis. Patients who did not receive TXA had numerically more frequent surgical intervention and longer length of stay, but these did not reach significance. Conclusions: TXA was utilized in 60% of pediatric trauma admissions at a single level 1 trauma center, more commonly in older patients. Although limited by observational design, we found patients receiving TXA had no difference in mortality or thrombosis.
Breastfeeding Duration in a Low-Income Sample Is Associated With Child Diet Quality at Age Three
Authors: Weinfield Nancy S. , Borger Christine , Gola Alice Ann 
Published: February 2020

Background Little research has focused on breastfeeding and diet quality, particularly in low-income populations at risk for shorter breastfeeding duration and poorer diet quality. Research Aim The aim of this study was to examine the association between breastfeeding duration and later diet quality in a low-income population. Methods For this longitudinal prospective cohort study we conducted a secondary analysis of data from the Infant and Toddler Feeding Practices Study-2, a national study of infant feeding practices and child outcomes. Study infants were enrolled in the Special Supplemental Nutrition Program for Women, Infants, and Children by 2.5 months of age and followed until 36 months ( N = 1,223). We examined the association between breastfeeding duration until 13 months of age, and child diet quality derived from a 24-hour dietary recall with a usual intake adjustment at child age 36 months. Multiple regression analyses were used to examine the association of breastfeeding duration with overall diet quality, as measured by the Heathy Eating Index 2015, and with consumption of specific food groups. Results Longer breastfeeding duration during infancy was associated with better diet quality at child age 36 months after controlling for key socio-demographic variables. In follow-up analyses, the origin of the association was narrowed to greater consumption of mature/dried beans and peas. Conclusions Longer breastfeeding duration in infancy was associated with better diet quality at 36 months, in a population at risk for shorter breastfeeding duration and poorer diet quality. Breastfeeding was particularly associated with children’s consumption of mature/dried beans and peas. Clinical Trial Registration This study is registered at clinicaltrials.gov as Feeding My Baby—A National WIC Study, NCT02031978
Intraperitoneal Insulin Reduces Plasma Leptin Concentration in Diabetic Patients on CAPD
Authors: Nevalainen Pasi I. , Lahtela Jorma T. , Mustonen Jukka , Pasternack Amos 
Published: February 2020

Objective To determine the effects of subcutaneous (SC) and intraperitoneal (IP) insulin on serum leptin concentration in type I diabetic patients with end-stage renal failure treated with continuous ambulatory peritoneal dialysis (CAPD). Design Prospective, open, before–after study. Setting Tertiary-care university hospital. Participants Twelve type I diabetic patients with stabilized CAPD, age 43.9 ± 2.8 years, and duration of diabetes 30.4 ± 3.5 years. Intervention After stabilized CAPD therapy, all patients were treated first with SC insulin for a median of 3 months, and thereafter with IP insulin for another 3 months. Main Outcome Measures Plasma leptin, insulin sensitivity with euglycemic clamp, and glycemic and uremic status after both treatment periods. Results During SC insulin therapy, plasma leptin concentration was significantly higher than during IP insulin (19.8 ± 5.9 ng/mL and 12.8 ± 6.2 ng/mL, respectively; p < 0.001). Leptin concentration was higher in CAPD patients and was related to body mass index in both genders. No correlation was detected between plasma leptin and fasting insulin, glycemic control, glucose disposal rate, or serum lipids. Conclusion Plasma leptin concentration is lower during IP insulin therapy compared to SC insulin. Insulin has probably a direct effect on both peritoneal leptin clearance and adipose tissue leptin production. The significance of leptin in regulating appetite and anorexia in uremia remains unclear.