bluuebunny/crossref_metadata_2025_split huggingface dataset:
Direct Recycling of Spent NCM Cathodes through Ionothermal Lithiation
Authors: Wang Tao , Luo Huimin , Bai Yaocai , Li Jianlin , Belharouak Ilias , Dai Sheng 
Published: June 2020

AbstractIonic liquids (ILs) are a family of nonconventional molten salts that offer many advantages, such as negligible vapor pressures, negligible flammability, wide liquidus ranges, good thermal stability, and much synthesis flexibility. The unique solvation environment of these ILs provides new reaction or flux media for controlling formation of solid‐state materials with a minimum perturbation of morphologies. A successful lithiation via ionothermal synthesis using a cost‐effective Li halide as Li source and recyclable ILs as solvents is reported here for the direct recycling of LiNi1/3Co1/3Mn1/3O2 (NCM 111) cathodes. In addition, the ionic liquids can be readily recycled and reused after ionothermal lithiation. The lithiation of spent cathodes can enable the direct recycling of spent cathode materials in lithium‐ion batteries.
A Dual Role by Incorporation of Magnesium in YbZn2Sb2 Zintl Phase for Enhanced Thermoelectric Performance
Authors: Zhang Zongwei , Yan Yirui , Li Xiaofang , Wang Xinyu , Li Juan , Chen Chen , Cao Feng , Sui Jiehe , Lin Xi , Liu Xingjun , Xie Guoqiang , Zhang Qian 
Published: June 2020

Abstract1‐2‐2‐type Zintl phase compounds have promising thermoelectric properties because of their complex crystal structures and multiple valence‐band structures. In this work, a series of single phase (Yb0.9Mg0.1)MgxZn2−xSb2 (x = 0, 0.2, 0.4, 0.6, 0.8, and 1) compounds are prepared by alloying YbZn2Sb2 with 10 at% MgZn2Sb2 and different amounts of YbMg2Sb2. The incorporation of Mg at the Yb site, as well as at the Zn site, not only leads to an effective orbital alignment confirmed by the dramatically enhanced density of states effective mass and Seebeck coefficients, but also increases the point defect scattering, contributing to a low lattice thermal conductivity ≈0.54 W m−1 K−1 at 773 K. Combined with the optimization of the carrier concentration by Ag doping at the Zn site, a highest ZT value ≈1.5 at 773 K is achieved in (Yb0.9Mg0.1)Mg0.8Zn1.2Ag0.002Sb2, which is higher than that of all the previously reported 1‐2‐2‐type Zintl phase compounds.
Enabling Iron‐Based Highly Effective Electrochemical Water‐Splitting and Selective Oxygenation of Organic Substrates through In Situ Surface Modification of Intermetallic Iron Stannide Precatalyst
Authors: Chakraborty Biswarup , Beltrán‐Suito Rodrigo , Hausmann J. Niklas , Garai Somenath , Driess Matthias , Menezes Prashanth W. 
Published: June 2020

AbstractA strategy to overcome the unsatisfying catalytic performance and the durability of monometallic iron‐based materials for the electrochemical oxygen evolution reaction (OER) is provided by heterobimetallic iron–metal systems. Monometallic Fe catalysts show limited performance mostly due to poor conductivity and stability. Here, by taking advantage of the structurally ordered and highly conducting FeSn2 nanostructure, for the first time, an intermetallic iron material is employed as an efficient anode for the alkaline OER, overall water‐splitting, and also for selective oxygenation of organic substrates. The electrophoretically deposited FeSn2 on nickel foam (NF) and fluorine‐doped tin oxide (FTO) electrodes displays remarkable OER activity and durability with substantially low overpotentials of 197 and 273 mV at 10 mA cm−2, respectively, which outperform most of the benchmarking NiFe‐based catalysts. The resulting superior activity is attributed to the in situ generation of α‐FeO(OH)@FeSn2 where α‐FeO(OH) acts as the active site while FeSn2 remains the conductive core. When the FeSn2 anode is coupled with a Pt cathode for overall alkaline water‐splitting, a reduced cell potential (1.53 V) is attained outperforming that of noble metal‐based catalysts. FeSn2 is further applied as an anode to produce value‐added products through selective oxygenation reactions of organic substrates.
Prophylaxis of Crohn's disease recurrence: A surgeon’s perspective
Authors: Wolford Dallas D. , Fichera Alessandro 
Published: June 2020

AbstractManagement of inflammatory bowel disease has evolved extensively in the last three decades. We have learnt a lot about the pathophysiology and natural history of the disease. New effective classes of drugs with the associated potential morbidity have been introduced. New surgical techniques have been popularized leading to a better understanding of the optimal timing of surgery. The result is a very complex subspecialty of gastroenterology and colorectal surgery called the "IBDologist." Only if we manage these complex patients in the context of a multi‐disciplinary team will we be able to obtain outstanding outcomes, specifically with high and sustained remission rates for these patients.
Synthesis of 1,3‐Bis‐(boryl)alkanes through Boronic Ester Induced Consecutive Double 1,2‐Migration
Authors: You Cai , Studer Armido 
Published: June 2020

AbstractA general and efficient approach for the preparation of 1,3‐bis‐(boryl)alkanes is introduced. It is shown that readily generated vinylboron ate complexes react with commercially available ICH2Bpin to valuable 1,3‐bis‐(boryl)alkanes. The introduced transformation, which is experimentally easy to conduct, shows broad substrate scope and high functional‐group tolerance. Mechanistic studies reveal that the reaction does not proceed via radical intermediates. Instead, an unprecedented boronic ester induced sequential bis‐1,2‐migration cascade is suggested.
Composition‐Tunable Antiperovskite CuxIn1−xNNi3 as Superior Electrocatalysts for the Hydrogen Evolution Reaction
Authors: Zhang Jiaxi , Zhang Longhai , Du Li , Xin Huolin L. , Goodenough John B. , Cui Zhiming 
Published: June 2020

AbstractA group of newly reported antiperovskite nitrides CuxIn1−xNNi3 (0≤x≤1) with tunable composition are employed as electrocatalysts for the hydrogen evolution reaction (HER). Cu0.4In0.6NNi3 shows the highest intrinsic performance among all developed catalysts with an overpotential of merely 42 mV at 10 mA cmgeo−2. Stability tests at a high current density of 100 mA cmgeo−2 show its super‐stable performance with only 7 mV increase in overpotential after more than 60 hours of measurement, surpassing commercial Pt/C (increase of 170 mV). By partial substitution, the derived antiperovskite nitride achieves a smaller kinetic barrier of water dissociation compared to the unsubstituted InNNi3 and CuNNi3, revealed by first‐principle calculations. It is found that the partially substituted CuxIn1−xNNi3 possesses a thermal neutral and desirable Gibbs free energy of hydrogen for HER, ascribed to the tailoring of the energy of d‐band center arose by the A‐site (A=Cu or In) substitution and a resulting optimization of adsorbate interactions.
An algebraic and suboptimal solution of constrained model predictive control via tangent hyperbolic function
Authors: Dursun Ufuk , Yıldız Taşçıkaraoğlu Fatma , Üstoğlu İlker 
Published: June 2020

AbstractIn this paper, we propose a novel method to solve the model predictive control (MPC) problem for linear time‐invariant (LTI) systems with input and output constraints. We establish an algebraic control rule to solve the MPC problem to overcome the computational time of online optimization methods. For this purpose, we express system constraints as a continuous function through the tangent‐hyperbolic function, hence the optimization problem is reformulated. There are two steps for the solution of the optimization problem. In the first step, the optimal control signal is determined by the use of the necessary condition for optimality, assuming that there is only input constraint. In the latter, the solution obtained in the first step is revised to keep the system states in a feasible region. It is shown that the solution is suboptimal. The proposed solution method is simulated for three different sample systems, and the results are compared with the classical MPC, which show that the new algebraic method dramatically reduces the computational time of MPC.
Aggregation‐induced integrated stress response rejuvenates culture‐expanded human mesenchymal stem cells
Authors: Bijonowski Brent M. , Fu Qin , Yuan Xuegang , Irianto Jerome , Li Yan , Grant Samuel C. , Ma Teng 
Published: June 2020

AbstractProtein homeostasis is critical for cellular function, as loss of homeostasis is attributed to aging and the accumulation of unwanted proteins. Human mesenchymal stem cells (MSCs) have shown promising therapeutic potential due to their impressive abilities to secrete inflammatory modulators, angiogenic, and regenerative cytokines. However, there exists the problem of human MSC expansion with compromised therapeutic quality. Duringin vitro expansion, human MSCs are plated on stiff plastics and undergo culture adaptation, which results in aberrant proliferation, shifts in metabolism, and decreased autophagic activity. It has previously been shown that three‐dimensional (3D) aggregation can reverse some of these alterations by heightening autophagy and recovering the metabolic state back to a naïve phenotype. To further understand the proteostasis in human MSC culture, this study investigated the effects of 3D aggregation on the human MSC proteome to determine the specific pathways altered by aggregation. The 3D aggregates and 2D cultures of human MSCs derived from bone marrow (bMSC) and adipose tissue (ASC) were analyzed along with differentiated human dermal fibroblasts (FB). The proteomics analysis showed the elevated eukaryotic initiation factor 2 pathway and the upregulated activity of the integrated stress response (ISR) in 3D aggregates. Specific protein quantification further determined that bMSC and ASC responded to ISR, while FB did not. 3D aggregation significantly increased the ischemic survival of bMSCs and ASCs. Perturbation of ISR with small molecules salubrinal and GSK2606414 resulted in differential responses of bMSC, ASC, and FB. This study indicates that aggregation‐based preconditioning culture holds the potential for improving the therapeutic efficacy of expanded human MSCs via the establishment of ISR and homeostasis.
Increased metal tolerance and bioaccumulation of zinc and cadmium in Chlamydomonas reinhardtii expressing a AtHMA4 C‐terminal domain protein
Authors: Ibuot Aniefon , Webster Rachel E. , Williams Lorraine E. , Pittman Jon K. 
Published: June 2020

AbstractThe use of microalgal biomass for metal pollutant bioremediation might be improved by genetic engineering to modify the selectivity or capacity of metal biosorption. A plant cadmium (Cd) and zinc (Zn) transporter (AtHMA4) was used as a transgene to increase the ability of Chlamydomonas reinhardtii to tolerate 0.2 mM Cd and 0.3 mM Zn exposure. The transgenic cells showed increased accumulation and internalization of both metals compared to wild‐type. AtHMA4 was expressed either as the full‐length (FL) protein or just the C‐terminal (CT) tail, which is known to have metal‐binding sites. Similar Cd and Zn tolerance and accumulation was observed with expression of either the FL protein or CT domain, suggesting that enhanced metal tolerance was mainly due to increased metal binding rather than metal transport. The effectiveness of the transgenic cells was further examined by immobilization in calcium alginate to generate microalgal beads that could be added to a metal contaminated solution. Immobilization maintained metal tolerance, while AtHMA4‐expressing cells in alginate showed a concentration‐dependent increase in metal biosorption that was significantly greater than alginate beads composed of wild‐type cells. This demonstrates that expressing AtHMA4 FL or CT has great potential as a strategy for bioremediation using microalgal biomass.
Sustainability disclosure and financial analysts' accuracy: The European case
Authors: Ferrer Elena , López‐Arceiz Francisco J. , del Rio Cristina 
Published: June 2020

AbstractThis study aims to analyze whether the adoption of Directive 2014/95/EU on sustainability disclosure has contributed to more truthful reporting to financial analysts in terms of risks and firms' performance. Financial analysts, as requesters of sustainability reports, are expected to have produced more accurate forecasts as a result of this legal reform. To investigate this, we have examined analysts' earnings per share (EPS) forecasts for 434 companies, 241 of which are classified as low sustainability companies, from 2008 to 2017. To detect a possible increase in EPS forecast accuracy after the enforcement of the directive, we perform an analysis based on panel regression specifications. The results show that EPS forecast accuracy has increased due to the higher levels of both sustainability disclosure and reporting quality after the enforcement of Directive 2014/95/EU.
Clinical outcomes among unresectable, locally advanced, and metastatic cutaneous squamous cell carcinoma patients treated with systemic therapy
Authors: Cowey C. Lance , Robert Nicholas J. , Espirito Janet L. , Davies Kalatu , Frytak Jennifer , Lowy Israel , Fury Matthew G. 
Published: June 2020

AbstractPrior studies of conventional chemotherapy or epidermal growth factor receptor inhibitors for advanced (ie, locally advanced cutaneous squamous cell carcinoma [laCSCC] or metastatic [mCSCC]) cutaneous squamous cell cancer enrolled ≤ 40 patients. This retrospective, observational study assessed real‐world treatment patterns and clinical outcomes in patients with unresectable laCSCC or mCSCC using electronic health records of patients who initiated first‐line (1L) systemic treatment from 1 January 2008 to 31 December 2015, with follow‐up to 30 September 2017. The median duration of follow‐up from 1L treatment was 10.1 months (range 0.03‐67.6 months). Duration of therapy (DOT) and overall survival (OS) were assessed using Kaplan‐Meier analysis. Response rate was calculated as the proportion of patients who achieved physician‐assessed‐response. Eighty‐two patients were identified (17 laCSCC and 65 mCSCC). Median age at 1L treatment initiation was 75 years; 85% were male, 88% had an Eastern Cooperative Oncology Group performance status of 1, and 84% had received radiotherapy. The most common 1L regimens were carboplatin + paclitaxel (27%) and cetuximab monotherapy (24%). The median 1L DOT was 4.1 months for laCSCC and 2.3 months for mCSCC. The physician‐assessed response rate for 1L therapy was 17.6% for laCSCC, and 18.5% for mCSCC. The median OS from 1L treatment initiation was 16.2 months for laCSCC, and 15.3 months for mCSCC. Only 24 patients (29%) received second‐line therapy. This is the largest retrospective data set regarding patients with advanced CSCC treated with anticancer systemic therapy prior to approval of the anti‐programmed cell death‐1 antibody, cemiplimab. Efficacy was low in both laCSCC and mCSCC. These data provide historic benchmarks for outcomes in patients with advanced CSCC prior to Food and Drug Administration approval of cemiplimab‐rwlc.
Financial Impact of Abusive Head Trauma to Age 17
Authors: Steinbeigle Ryan , Barr Marilyn , Barr Ronald G. , Miller Ted R. 
Published: June 2020

In order to illustrate the medical and financial impact arising from the care of a severely injured victim of abusive head trauma (AHT) from incident through to adulthood, a complete review of all medical financial files for the injured child beginning at the time custody of the child was transferred to the paternal grandparents (2.5 months of age) through to age 17 was conducted. Cost data were extracted from the insurance explanation of benefits or the family's bank statements. Costs were divided into seven categories and adjusted for inflation using the gross domestic product medical care deflator. Medical costs from 2.5 months to 18 years of age totaled $261 499, with $106 607 of out‐of‐pocket expenditures by the child's paternal grandparents and $154 892 covered by insurance. Costs were highly variable from year to year as reflected in the standard deviation of annual costs of $16 877. The cost of caring for a seriously injured victim of AHT is substantial. The costs may be highly variable and unpredictable from year to year making it difficult for families to plan financially.Key Practitioner Messages

The financial impact of AHT on a family can be substantial and unaffordable.
The financial impact for a family varies wildly from year to year.
The often unaffordability of caring for a victim of AHT limits the quality and access to care in households with lower incomes.
Uncovering Biological Application of Brazilian Green Propolis: A Phenotypic Screening againstSchistosoma mansoni
Authors: A. de L. Paula Lucas , Santos Mario F. C. , Pagotti Mariana C. , Faleiros Renata , Ramos Henrique P. , Veneziani Rodrigo C. S. , Bastos Jairo K. , Caffrey Conor R. , Ambrosio Sérgio R. , Magalhães Lizandra G. 
Published: June 2020

AbstractThe chemotherapy of schistosomiasis remains centered in the use of praziquantel, however, there has been growing resistant parasites to this drug. Thus, the aim of this work was to evaluatein vitroschistosomicidal activity of the hexanes/dichloromethane 1 : 1 extract of Brazilian green propolis (Pex), as well as its major isolated compounds artepillin C, caffeic acid, coumaric acid and drupanin againstSchistosoma mansoni. The Pex was active by displaying an IC50value of 36.60 (26.26–51.13) μg mL−1at 72 h against adult worms ofS. mansoni. The major isolated compounds were inactive with IC50values >100 μM, however, the combination of the isolated compounds (CM) in the same range found in the extract was active with an IC50value of 41.17 (39.89–42.46) μg mL−1at 72 h. Pex and CM induced alteration in the tegument ofS. mansoni, and caffeic acid caused alteration in egg's maturation. Pex displayedin vitroactivity against adult worms’ and eggs’ viability ofS. mansoni, which opens new perspectives to better understand the synergistic and/or additive effects promoted by both Pex extract and CM against schistosomiasis features.
European Bifurcation Club white paper on stenting techniques for patients with bifurcated coronary artery lesions
Authors: Burzotta Francesco , Lassen Jens Flensted , Louvard Yves , Lefèvre Thierry , Banning Adrian P. , Daremont Olivier , Pan Manuel , Hildick‐Smith David , Chieffo Alaide , Chatzizisis Yiannis S. , Džavík Vladimír , Gwon Hyeon‐Cheol , Hikichi Yutaka , Murasato Yoshinobu , Koo Bon Kwon , Chen Shao‐Liang , Serruys Patrick , Stankovic Goran 
Published: June 2020

AbstractBackgroundDefining the optimal conduction of percutaneous‐coronary‐intervention (PCI) to treat bifurcation lesions has been the subject of many clinical studies showing that the applied stenting technique may influence clinical outcome. Accordingly, bifurcation stenting classifications and technical sequences should be standardized to allow proper reporting and comparison.MethodsThe European Bifurcation Club (EBC) is a multidisciplinary group dedicated to optimize the treatment of bifurcations and previously created a classification of bifurcation stenting techniques that is based on the first stent implantation site. Since some techniques have been abandoned, others have been refined and dedicated devices became available, EBC promoted an international task force aimed at updating the classification of bifurcation stenting techniques as well as at highlighting the best practices for most popular techniques. Original descriptive images obtained by drawings, bench tests and micro‐computed‐tomographic reconstructions have been created in order to serve as tutorials in both procedure reporting and clinical practice.ResultsAn updated Main‐Across‐Distal‐Side (MADS)‐2, classification of bifurcation stenting techniques has been realized and is reported in the present article allowing standardized procedure reporting in both clinical practice and scientific studies. The EBC‐promoted task force deeply discussed, agreed on and described (using original drawings and bench tests) the optimal steps for the following major bifurcation stenting techniques: (a) 1‐stent techniques (“provisional” and “inverted provisional”) and (b) 2‐stent techniques (“T/TAP,” “culotte,” and “DK‐crush”).ConclusionsThe present EBC‐promoted paper is intended to facilitate technique selection, reporting and performance for PCI on bifurcated lesions during daily clinical practice.
Myocardial ischemia due to a recanalized chronic coronary thrombus: Angiographic and optical coherence tomography imaging insights
Authors: Sacchetta Giorgio , Scalise Renato Francesco Maria , Garcia Ruiz Victoria , Barrano Giombattista , Garro Nadia , Costa Francesco , Contarini Marco 
Published: June 2020

AbstractChronic organized thrombus as a result of prior untreated myocardial infarction can determine myocardial ischemia. This entity appears as an angiographically irregular and hazy image; optical coherence tomography is useful to evaluate these ambiguous lesions and guide interventional treatment.
Meadow fescue seeding rate impacts mixtures with alfalfa on marginal sites
Authors: Cherney J.H. , Cherney D.J. 
Published: June 2020

AbstractAlfalfa (Medicago sativa L.)–grass mixtures are often used to provide high‐quality dairy forage in the northeastern United States. Meadow fescue (Festuca pratensis Huds.) is popular as a companion for alfalfa in the region because of its high nutritive value. We aimed to evaluate alfalfa–meadow fescue mixtures in northern environments that are unsuited to alfalfa production. Our study was conducted in the year after seeding at two northern New York sites. A reduced‐lignin [fall dormancy (FD) = 4] and a conventional alfalfa (FD = 3) were seeded with diploid and tetraploid meadow fescue varieties in replicated plots, with five seeding rates for meadow fescue. Dry matter yield increased linearly with increased meadow fescue seeding rate. The meadow fescue percentage of mixtures had a curvilinear response to meadow fescue seeding rate, increasing from 44% at the 0.5 lb acre–1 seeding rate to 67.4% at the 4 lb acre–1 rate. Tetraploid meadow fescue had a smaller grass percentage in mixtures and higher nutritive value than a diploid meadow fescue. Reduced‐lignin alfalfa was not greatly different in nutritive value from a conventional cultivar under unfavorable environmental conditions for alfalfa production. We conclude that meadow fescue should be seeded at a very low rate (1 lb acre–1) with alfalfa in northern environments that are unsuitable for alfalfa. Moreover, reduced‐lignin alfalfa (FD = 4) may not result in large increases in nutritive value compared with conventional cultivars selected for high nutritive value on marginal northern sites better suited to FD 3 cultivars.
Opening the Third Century of Polyhalide Chemistry: Thermally Stable Complex with “Trapped” Dichlorine
Authors: Usoltsev Andrey N. , Adonin Sergey A. , Kolesov Boris A. , Novikov Alexander S. , Fedin Vladimir P. , Sokolov Maxim N. 
Published: June 2020

AbstractUnlike polyhalides of heavier halogens, polychlorides still remain exotic curiosities. Herein, we report preparation and investigation of complexes Cat2{[TeCl6](Cl2)} (cat=1‐methylpyridinium (1) and tetramethylammonium (2)) where dichlorine units are “trapped” by chlorotellurate(IV) anions via a system of non‐covalent Cl⋅⋅⋅Cl interactions. Complex 2 reveals a record thermal stability (>100 °C) for inclusion compounds with Cl2, indications that such compounds can be used as solid Cl2 source.