bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic value of socioeconomic parameters among the Russian population aged 25-64: results of a population-based study
Authors: Imaeva A. E. , Balanova Yu. A. , Gomanova L. I. , Kutsenko V. A. , Imaeva N. A. , Nazarov B. M. , Kapustina A. V. , Evstifeeva S. E. , Muromtseva G. A. , Shalnova S. A. , Drapkina O. M. 
Published: February 2025

Aim. To assess the contribution of individual socioeconomic parameters to the risk of death and cardiovascular events among Russian men and women aged 25-64, according to epidemiological study data.Material and methods. The study was based on data from the prospective study ESSE-RF (2013-2014) and ESSE-RF2 (2017), which included a total of 22812 participants aged 25-64 years from 14 regions. The analysis assessed the following sociodemographic parameters: marital status, education level, income, employment, and type of settlement. From 2013 to 2021, 688 participants died. The composite endpoint (CE), including fatal and non-fatal (myocardial infarction and/or cerebrovascular accident) cardiovascular events, was registered in 470 (4,6%) men and 380 (2,4%) women. Associations with endpoints were assessed using Cox proportional hazards models with corresponding hazard ratios (HR).Results. According to multivariate analysis, the following parameters were significantly associated with the all-cause death risk in the male population: non-marriage (HR 1,86, 95% confidence interval (CI): 1,48-2,33), no higher education (HR 1,34, 95% CI: 1,08-1,67), low income (HR 1,32, 95% CI: 1,06-1,63), non-employment (HR 1,97, 95% CI: 1,58-2,46); with CE — no higher education (HR 1,64, 95% CI: 1,34-2,01), nonemployment (HR 1,49, 95% CI: 1,21-1,84). In the population of women, a reliable contribution to all-cause death risk and CE occurrence was made by the lack of higher education and non-employment — HR 1,54, 95% CI: 1,17-2,04; HR 1,64, 95% CI: 1,26-2,14; HR 1,35, 95% CI: 1,07-1,71; HR 1,38, 95% CI: 1,1-1,73, respectively.Conclusion. The study results indicate that the most unfavorable prognostic factors in relation to death risk and fatal and non-fatal cardiovascular events are the lack of higher education and nonemployment, regardless of sex and region of residence.
Evaluation of changes in bone mass and subclinical atherosclerosis indices in asymptomatic women over a 10-year period
Authors: Skripnikova I. A. , Kosmatova O. V. , Kolchina M. A. , Isaykina O. Yu. , Vygodin V. A. , Drapkina O. M. 
Published: February 2025

Aim. To study the changes of vascular stiffness, subclinical atherosclerosis, bone mineral density (BMD) and to identify cases of cardiovascular disease (CVD) manifestation over a 10-year period.Material and methods. We analyzed 93 menopausal women without clinical manifestations of atherosclerosis at the study start, who underwent outpatient examination twice at the National Medical Research Center for Therapy and Preventive Medicine with an interval of 10 years. All women were surveyed for risk factors, fractures, and CVDs. In addition, pulse wave velocity and augmentation index were measured using applanation tonometry, carotid artery ultrasound to determine the intima-media thickness and register plaques, and BMD was measured using dual-energy X-ray absorptiometry.Results. During the follow-up period, among the CVD risk factors, only the prevalence of hypertension increased by 32,2% (p<0,001). By visit 2, an increase in the augmentation index and intima-media thickness, the number of plaques (p<0,001), as well as a decrease in BMD in the femoral neck by 5,3% and in the proximal femur by 3,2% (p<0,001), but not in the spine, were noted. CVD were detected in 8 (9%) women.Conclusion. This retrospective and prospective study demonstrated a significant increase in subclinical atherosclerosis, vascular stiffness, with the exception of pulse wave velocity, and a decrease in bone mass in postmenopausal women over a 10-year follow-up period.
Vaccination against the SARS-CoV-2 in individuals with comorbidities
Authors: Berns S A , Chashсhin M G , Gorshkov A Yu , Zhdanova O V , Ryzhakova L N , Litinskaya O A , Drapkina O M 
Published: February 2025

Aim. To assess post-vaccination period and the incidence of coronavirus disease 2019 (COVID-19) in comorbid individuals vaccinated and revaccinated against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).Material and methods. The study was conducted within the prospective SATURN registry, which included individuals who received various revaccination regimens against the SARS-CoV-2 (homoand heterologous regimens) based on a combination of two vaccines (GamCOVID-Vac and CoviVac). A total of 200 respondents participated in the study, who were divided into 2 groups depending on the Charlson comorbidity index score. Group I included participants (n=172) with a score of 0-1, which implies a high percentage (99-96%) of survival in the next 10 years. Group II included participants (n=28) with a Charlson index score of 2-4, where the survival rate is significantly lower and varies from 90 to 53%.Results. One year after vaccination (visit 3) and further in each of the groups, the anti-SARS-CoV-2 IgG level significantly exceeded the reference values (≥499 BAU/ml). The immunity durability was maintained throughout the entire follow-up period. The COVID-19 rate in the post-vaccination period (visit 3 and further) among the study participants varied from 0 to 50% of respondents in different groups (p>0,05). During the same time periods, according to the Hospital Anxiety and Depression Scale (HADS), the median of both anxiety and depression in each of the groups ranged from 0 to 7, which indicates the absence of severe symptoms of these conditions in most program participants. The prevalence of suband clinically pronounced depression did not differ between the groups at each visit. The incidence of clinical anxiety at visit 3 was significantly higher in the group of comorbid patients (16,7 vs 1,8%, p<0,05). However, during further follow-up in group II, there was not a single participant with clinical anxiety.Conclusion. The use of Russian vaccines (Gam-COVID-Vac and CoviVac) is equally effective in each of the studied groups. There were no significant differences between them in COVID-19 incidence after vaccination/revaccination. When assessing the post-vaccination period, our attention was focused on the mental status of the participants. During one of the control visits at the revaccination stage (visit 3), the incidence of clinical anxiety in the group of comorbid patients (II) was higher. However, establishing the cause-and-effect relationships with other factors is currently difficult and requires further research.
Assessment of heart-evoked potentials in hypertensive patients
Authors: Sukmanova A. A. , Minenko I. A. , Limonova A. S. , Guseynova K. A. , Bashankaeva Z. B. , Moiseeva V. V. , Ershova A. I. , Drapkina O. M. 
Published: February 2025

In recent years, interoception, described as the ability to perceive signals from internal organs, has been actively studied. However, the relationship between cardiovascular diseases and neurophysiological characteristics of interoception remains poorly understood.Aim. In this work, we studied neurophysiological markers of interoception in a group of patients with hypertension. Heart-evoked potentials (HEPs) were used as neurophysiological markers.Material and methods. The study included 41 patients with HTN (2250 years old, 80,5% received antihypertensive therapy) and 41 people from the control group (26-50 years old), matched for sex and age. Interoception was studied at the behavioral level by heartbeat tracking task (HTT) and at the neuronal level by the electroencephalography method to record HEPs. Participants filled out the Toronto Alexithymia Scale questionnaire.Results. No significant differences in the accuracy of heartbeat sensations and HEP amplitudes were found between the HTN and control group, as well as significant relationships between accuracy of heartbeat sensations and HEP amplitudes in both groups. Significant positive correlations were found between the HEP amplitudes and the alexithymia indices in both groups.Conclusion. No differences in HEP amplitudes were found between the patients with hypertension and the control group. However, for the first time, a relationship was demonstrated between difficulties in recognizing emotions and HEP amplitudes in hypertensive patients, confirming the hypothesis about the interaction of these processes at insular cortex level.
Mortality from chronic ischaemic heart disease in the Russian Federation: are there enough data for analysis and decision-making?
Authors: Shepel R. N. , Samorodskaya I. V. , Kakorina E. P. , Drapkina O. M. 
Published: February 2025

Aim. To discuss the role of coding the underlying cause of death based on International Statistical Classification of Diseases and Related Health Problems, 10th Revision (ICD-10) in changing the standardized mortality rates (SMR) from various chronic ischaemic heart disease (CIHD) in the Russian Federation in 2014-2023.Material and methods. The analysis of Rosstat data on the number of patients who died from CIHD and its individual forms for 2014-2023 was performed in accordance with the Brief Nomenclature of Causes of Death of Rosstat. The calculations were performed using the computer program "Calculation and Analysis of Mortality Rates and Years of Life Lost as a Result of Premature Mortality in the Subjects of the Russian Federation" developed at the National Medical Research Center for Therapy and Preventive Medicine. For SMR estimation, the World Health Organization European Standard Population (1976) was used. Accumulation, adjustment and systematization of the original information were carried out in Microsoft Office Excel 2016.Results. In the Russian Federation as a whole, the SMR from CIHD decreased by 14,6% in 2014-2023 (from 196,2 to 167,5 per 100 thousand population). The share of CIHD in all-cause mortality did not change significantly, while its share in all ischaemic heart disease forms increased annually. We found a decrease in SMR from "I25.0 Atherosclerotic cardiovascular disease, so described" (by 82,5%), "I25.1 Atherosclerotic heart disease" (by 22,3%), "I25.9 CIHD, unspecified" (by 84,1%) against the background of an increase in the group of other forms of CIHD (I25.2-6.8) (by 40%) with an increase in the contribution of CIHD from 25,37 to 41,32%. The proportion of CIHD without clinical criteria (I25.0-1.9) remains high (~60%).Conclusion. Tendencies towards a decrease in mortality from CIHD were revealed with an increase in the proportion of CIHD in all ischaemic heart disease forms. The share of unspecified codes and forms of CIHD as the cause of death has decreased. There is a need for uniform Russian guidelines, in which CIHD classification according to ICD-10 would be adapted to clinical terminology and the most probable clinical variants of the disease course and causes of death. Clarification of criteria and typification of coding approaches will contribute to a better understanding of the causes and subsequent adoption of targeted management decisions.
Issues of concern and development of classifications of the main parameters of therapy quality and compliance. Part III: quality of pharmacotherapy
Authors: Lukina Yu. V. , Kutishenko N. P. , Martsevich S. Yu. , Drapkina O. M. 
Published: February 2025

This article is the third work in a series of publications on consideration of the main parameters of therapy quality and compliance and the development of their classifications. The aim is to determine, based on scientific literature data, the main parameters reflecting the quality of therapy and to develop their classification.According to the World Health Organization, more than half of all drugs are prescribed and sold improperly, and half of all patients take their medications inadequately. To date, there is no generally accepted terminology and classification regarding the quality of therapy. The closest synonym for this concept is "rational/irrational pharmacotherapy". There are special scales and lists of criteria that reflect the quality of prescribed therapy and can be used to assess it. The main parameters of pharmacotherapy quality are the effectiveness and safety of treatment; some lists also include medication adherence. Data on the effectiveness and safety of drugs with proven efficacy for a certain disease are available in clinical guidelines. Information on aspects of drug safety is usually most fully presented in official instructions for medical products, which, along with clinical guidelines, are the main supporting documents in determining the quality parameters of pharmacotherapy. Also, a number of indices have been developed for the quantitative assessment of pharmacotherapy quality, both special (for certain diseases) and universal.Based on the identified main parameters of pharmacotherapy quality, effectiveness and safety, as well as the subcategories of these parameters, we developed a classification.The proposed classification of pharmacotherapy quality parameters can be used as a "roadmap" in prescription of pharmacotherapy and contribute to increasing its effectiveness, safety, personalization, i.e. pharmacotherapy quality in general. This will ultimately make it more likely to achieve the main goals of this treatment in real-world practice.
Visual Perceptual Deficits in Different Types of Cerebral Palsy
Authors: Berelowitz Sharna , Franzsen Denise 
Published: February 2025

AbstractIntroduction: Children with cerebral palsy (CP) have been found to present with visual perceptual impairments (VPI). Research indicates differences in VPI in various subtypes of CP. However, visual perceptual deficits in children with CP has not been investigated in terms of occupational therapy assessment and treatment in a South African context. The purpose of this study was to determine the specific VPI in learners ages 4-18 years with various subtypes of CP attending a school for learners with special needs in Johannesburg, South Africa.Method: The Test of Visual Perceptual Skills 3rd ed. (TVPS-3) was used to assess 80 learners and their subtest scores and composite scores were compared according to their subtype of CP as well as other demographic variables including age, gender and GMFCS level.Results: All the subtypes of CP were found to present with VPI, with the right spastic unilateral (hemiplegic) group having the fewest number of impairments and the ataxic group greatest number of impairments. A significant difference in visual discrimination and figure ground scores were found based on the subtype of CP while the Composite Basic Processes scores on the TVPS-3 differed significantly for both the subtypes of CP and gender. No significant differences were found for VPI based on age and GMFCS levels. Conclusion: Visual perceptual impairments were found in a high percentage of participants with CP with significant differences between the subtypes of CP and according to gender but not for age and GMFCS levels.Â Key words: Cerebral Palsy, Visual Perception, TVPS-3, Visual Perceptual Impairment, Occupational Therapy
The Health-Related Quality of Life of Children Admitted for Cancer Management
Authors: Tembe S'thembiso Charles , Franzsen Denise , Koch Lyndsay , De Witt Patricia 
Published: February 2025

ABSTRACTIntroduction: South African children with cancer are admitted to specialised oncology units for the duration of their treatment in the public health system. These units are thus a temporary environment for varying periods of time, which disrupts the children's participation in daily activities and consequently their Health Related Quality of Life (HRQoL).Methodology: A quantitative, descriptive, cross-sectional study was conducted in a tertiary hospital with a specialist oncology unit in Gauteng to determine the HRQoL of children admitted with cancer from their own and their parent's perspective. Structured interviews were conducted with the children aged 8-12 years using the PedsQLTM Generic Core Scale (4.0) and Cancer Module (3.0). The parent's perspective was explored using the Parents proxies form of the PedsQLTM scales.Results: Twenty-five children and their parents participated in the study. Most children in the sample were males and Leukaemia and chemotherapy being the most common diagnosis and treatment received. All children and parents reported the children's functioning at an intermediate level on the Generic Core Scale (4.0) and on the Cancer Module (3.0) that schooling and emotional functioning were most affected. This suggests that these children are at risk for HRQoL deficits.Â This study also found that parents under- and over-estimated their children's HRQoL in various domainsConclusion: This study indicates the need for occupational therapists to understand the occupational disruption experienced by children during the treatment of cancer and monitor and provide support for this, to reduce the effect of impaired HRQoL.
An analysis of complaints against dentists made to the HPCSA: 2009-2023
Authors: Vedan  Theesan Ananda , Holmes Haly , Moodley Gillian Pryadarshini 
Published: February 2025

The study aims to provide an updated description of HPCSA complaints against dentists. The objectives were to analyse the incidence, types and consequences of professional misconduct and unprofessional behaviour complaints against South African dentists from 2009-2023
Frans Francken II’s Allegories of "Fortune" and "Occasio-Opportunity" revisited
Authors: Amaral Jr. Rubem 
Published: February 2025

In this note, reference is made to the paintings of the Dutch artist Frans Francken II, or the Young, on the themes of Fortune and Occasio-Opportunity, and a summary is given of the present state of the discussion on the interpretation of the motifs of the pictures on the latter subject, and notice is given of a new work in that series, not considered until now by those who have dealt with this matter.
Los colores en la heráldica de los libros de caballerías
Authors: López-Fanjul de Argüelles Carlos 
Published: February 2025

Se analiza en detalle el simbolismo expresado mediante los colores del campo del escudo y la cota de armas de los personajes de 36 libros de caballerías impresos en el siglo XVI, y se comparan las preferencias cromáticas literarias con las observadas en la heráldica castellana real compuesta durante ese mismo periodo y también con las desarrolladas previamente en las novelas del ciclo artúrico. Las correspondencias entre colores y sentimientos propuestas por los tratadistas del siglo XV tuvieron una influencia determinante en el entintado de los escudos novelescos, pero afectaron muy poco a la coloración de los auténticos, exceptuando la promoción de un decidido gusto por el verde que, sin embargo, careció de intenciones simbólicas. El uso de alegorías cromáticas fue mucho más amplio en los libros de caballerías que en la literatura artúrica y la elección de colores en cada caso respondió a propósitos generalmente diferentes.
Creative Training Approaches and Cultural Adaptability When Participating in International Events among Martial Arts Athletes
Authors: Li Yanan 
Published: February 2025

In the globalized arena of martial arts, cultural adaptability has emerged as a critical determinant of athletic success, complementing physical and technical prowess. This study explores innovative training approaches that integrate cultural adaptability into martial arts programs, emphasizing their role in preparing athletes for the complexities of international competition. Research indicates that culturally adaptable athletes exhibit enhanced stress management, focus, and performance in diverse environments. Key strategies include scenario-based learning (e.g., role-playing and simulations), cultural immersion, and technology-driven tools such as virtual reality (VR) and AI, which simulate cross-cultural interactions and environments. Mentorship from culturally competent coaches and participation in international exchange programs further strengthen athletes' intercultural communication skills and resilience. Studies highlight that such training not only improves competitive outcomes but also fosters cultural sensitivity, mutual respect, and sportsmanship. Additionally, culturally informed programs mitigate risks of misunderstandings and conflicts during global events, contributing to athletes' personal and professional growth. As martial arts continue to expand globally, the integration of cultural adaptability into training regimens is imperative. This synthesis of physical, technical, and intercultural preparation positions athletes to thrive in an increasingly interconnected sporting world, underscoring the necessity for continued innovation in training methodologies.
Key elements addressed 1. The growing importance of cultural adaptability in international martial arts competitions. 2. Evidence-based training methods (scenario-based learning, VR/AI, mentorship, exchanges). 3. Outcomes: Enhanced performance, resilience, cultural awareness, and conflict mitigation. 4. Future implications for globalized sports training.
¿Cuál es el efecto del rol de las mujeres rurales sobre la adecuada cloración del agua? Evidencia para el caso peruano
Authors: Sotelo Tornero Marisela , Arias Callupe Waldir 
Published: February 2025

Esta investigación analiza la relevancia del rol de las mujeres rurales sobre la adecuada cloración del agua, considerando una evaluación a nivel nacional rural, así como las diferencias que existen entre los centros poblados concentrados y dispersos. Este estudio enfoca su análisis en aquellos centros poblados con menos de 2000 habitantes y que son abastecidos en los servicios de agua y alcantarillado por algún prestador rural denominado en Perú organización comunal. De acuerdo con la revisión de la literatura, se sugiere que, una escasa participación de las mujeres en organizaciones comunales representa uno de los factores que contribuyen a que el índice de agua apta para consumo humano siga siendo muy bajo. En esta línea, para llevar a cabo el estudio, se emplearon los datos recopilados del informe Diagnóstico sobre el abastecimiento de agua y saneamiento en el ámbito rural - DATASS 2020, publicado por el Ministerio de Vivienda, Construcción y Saneamiento (MVCS) (2020), que brinda información sobre los servicios de saneamiento en los centros poblados rurales. Las afirmaciones planteadas en la hipótesis se validan en la sección Resultados mediante un análisis de regresión probabilística, utilizando un índice de calidad del servicio de agua que se representa a través de la adecuada cloración de la misma.