bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vitamin E nanoparticles enhance performance and immune status of Nile tilapia
Authors: Farag Enas A. H. , Baromh Mohamed Z. , El-kalamwi Naglaa , Sherif Ahmed H. 
Published: December 2024

AbstractVitamin E (VE) is an essential vitamin liposoluble antioxidant in aquatic animals that is usually lost during feed processing and digestion, whereas nano-chitosan, a polysaccharide, could protect VE. In this study, Nile tilapia (70.85 ± 0.2 g) was fed VE (100 mg/kg dry diet) and a chitosan protected-VE nanoparticle (NPs) with gradual percentages of recommended dose 25%, 50%, 75%, and 100% for 4, 6, and 8 weeks. Growth parameters total weight gain (TG), daily weight gain (DWG), and relative growth rate (RGR) were significantly and positively correlated with VENPs additions. Regardless of the addition level, the feed conversion ratio (FCR) was significantly lower in the VENP groups. Lysozyme, serum antibacterial activity, and oxidative burst activity indicated the superiority of VENPs (VENPs75 and VENPs100) in enhancing the fish’s innate immunity compared to bulk VE and the control groups. Fish were experimentally challenged with pathogenic Aeromonas hydrophila; those received dietary showed a low mortality rate (MR%), about 40% compared with 70% in the control with lower re-isolation compared to the control and VE groups. VENPs could provide ascending relative protection level during the period of 4 to 8 weeks; RPL ranged from 33.3 to 42.86% (VENPs100), 16.67–42.86% (VENPs75), 0 to 28.57% (VENPs50), and 0 to 14.29% (VENPs25 and VE), respectively. Finally, this study recommended incorporating VENPs into the Nile tilapia diet at 50, 75, and 100 mg/ kg fish feed. Fish in the VENPs75 and VENPs100 groups were immune boosted, becoming less vulnerable to A. hydrophila infection.
Functional circuits of LYL1 controlled by supraphysiological androgen in prostate cancer cells to regulate cell senescence
Authors: Heidari Horestani Mehdi , Schindler Katrin , Baniahmad Aria 
Published: December 2024

Abstract
Background
Prostate cancer (PCa) is a public health problem mostly reported in developed countries. The androgen receptor (AR) regulates the development and physiological function of normal prostate as well as the proliferation of cancerous prostate tissue. Treatment with supraphysiological androgen levels (SAL) is used in bipolar androgen therapy and inhibits PCa growth, suggesting SAL induces a tumor suppressive program. It was shown that SAL induces cellular senescence, in PCa cell lines, human tumor samples and in xenografted mouse tumor model.

Methods
Transcriptome and ChIP-seq analysis, PCa spheroids, knockdown (KD), co-immunoprecipitation, qRT-PCR, immune detection, in situ histochemistry.

Results
Here we show that LYL1 is upregulated by the clock gene BHLHE40 in both C4-2 and LNCaP cells and mediates SAL-induced cellular senescence. LYL1 is a transcriptional co-factor with oncogenic activity in leukemia. However, analysis of a large cohort of PCa patients shows that LYL1 expression is reduced during PCa development and reduced expression is significantly associated with reduced overall survival. SAL induces the expression of LYL1 through upregulation of BHLHE40. On the other hand, the KD of LYL1 enhances BHLHE40 expression via a negative feedback loop including p27kip1. Regulatory feedback loops were identified by rescue experiments. Functional analysis revealed that KD of BHLHE40 reduces whereas LYL1 KD enhances p27kip1 levels. The KD of p27kip1 suggests that this cell cycle inhibitor is a mediator of cellular senescence by the BHLHE40 - LYL1 regulatory loop. Interestingly, ChIP-seq data revealed recruitment of both AR and BHLHE40 to the LYL1 gene indicating that LYL1 is a novel direct target of both factors. Furthermore, RNA-seq data from C4-2 cells suggests that LYL1 and BHLHE40 encompass a large overlap of genes by SAL suggesting a co-regulatory activity controlled by androgens. In line with this, co-immunoprecipitation suggests LYL1 is in a complex with BHLHE40 and the AR.

Conclusions
Three novel feed-back loops and a novel AR- BHLHE40 / LYL1 -p27kip1 axis has been identified mediating cellular senescence in PCa cells.

Graphical Abstract
The top 100 most-cited articles on artificial intelligence in breast radiology: a bibliometric analysis
Authors: Singh Sneha , Healy Nuala A. 
Published: December 2024

Abstract
Introduction
Artificial intelligence (AI) in radiology is a rapidly evolving field. In breast imaging, AI has already been applied in a real-world setting and multiple studies have been conducted in the area. The aim of this analysis is to identify the most influential publications on the topic of artificial intelligence in breast imaging.

Methods
A retrospective bibliometric analysis was conducted on artificial intelligence in breast radiology using the Web of Science database. The search strategy involved searching for the keywords ‘breast radiology’ or ‘breast imaging’ and the various keywords associated with AI such as ‘deep learning’, ‘machine learning,’ and ‘neural networks’.

Results
From the top 100 list, the number of citations per article ranged from 30 to 346 (average 85). The highest cited article titled ‘Artificial Neural Networks In Mammography—Application To Decision-Making In The Diagnosis Of Breast-Cancer’ was published in Radiology in 1993. Eighty-three of the articles were published in the last 10 years. The journal with the greatest number of articles was Radiology (n = 22). The most common country of origin was the United States (n = 51). Commonly occurring topics published were the use of deep learning models for breast cancer detection in mammography or ultrasound, radiomics in breast cancer, and the use of AI for breast cancer risk prediction.

Conclusion
This study provides a comprehensive analysis of the top 100 most-cited papers on the subject of artificial intelligence in breast radiology and discusses the current most influential papers in the field.

Clinical relevance statement
This article provides a concise summary of the top 100 most-cited articles in the field of artificial intelligence in breast radiology. It discusses the most impactful articles and explores the recent trends and topics of research in the field.

Key Points

Multiple studies have been conducted on AI in breast radiology.

The most-cited article was published in the journal Radiology in 1993.

This study highlights influential articles and topics on AI in breast radiology.

Graphical Abstract
Pediatricians at the forefront of child mental health? A Delphi method exploration
Authors: Pinchover Shulamit , Berger Raanan Rony , Gadassi Hava , Shalev Amit , Dahari Dasi , Gutentag Tony , Rudolf Mary 
Published: December 2024

Abstract
Background
Rising mental health challenges among children and adolescents are a global concern. However, a shortage of professionals, inadequate competence and lack of resources hamper necessary care, presenting a major challenge to health service provision. Community pediatricians, frequently the initial contact for mental health issues, are in a key position to improve access to care. The Delphi method was employed as an initial step toward redefining the role of pediatricians and the re-design of pediatric responses within Israeli primary mental health care.

Method
Ninety-two experts, including pediatricians, psychiatrists, mental health and child-development professionals, and parents of children with emotional-behavioral challenges participated in a three-round Delphi study. A survey including 6 topics (37 items, 9 demographic questions) was distributed, probing the envisioned role of pediatricians in children’s mental health care.

Results
There was strong endorsement between experts regarding pediatricians’ potential roles in risk identification, parental guidance, psycho-education, and health policy isuues such as referrals to mental health professionals, and the need for training in this domain. However, discord arose concerning changes in the service framework and pediatricians’ role in psychiatric drug prescription. The majority agreed on the necessity of close support from mental health experts, despite differing in the form it should take.

Conclusions
This study underscores the critical need for mental health training among pediatricians and advocates for a structured, consensus-driven model to bolster early detection and initial treatment of mental health issues in children. The findings highlight the potential for leveraging this model to drive health policy changes and improve service delivery in pediatric mental health care, and might inform other health systems considering extending pediatricians’ roles. By equipping pediatricians with essential competencies, this approach can broaden mental health service delivery and reduce stigma. Aligning the model with expert consensus paves the way for impactful policy reform, enhancing pediatricians’ roles in mental health risk identification and intervention, and advancing child health services.
Defect engineering strategy to enhance the SO2 adsorption performance of Zr-based MOFs materials: potential application for purifying cultural heritage storage environments
Authors: Shi Meirong , Zejin  , Wang Yongjin , Jia Nan , Sha Zhongping , Fu Peng 
Published: December 2024

Abstract
In this work, a novel Zr-based MOFs material (D-NH2-UiO-66) with multi-stage pore structure was prepared by introducing defects in NH2-UiO-66 through a ligand regulation strategy, aiming to enhance the SO2 adsorption performance and be applied to purify the cultural relic storage environment. The research demonstrated that the defect engineering effectively increased the pore diameter of the precursor material, leading to the exposure of internal adsorption sites within the framework and the utilization of defect sites, thereby increasing the number of adsorption sites. Moreover, the enlargement of pore diameter facilitated the diffusion of gas molecules within the framework, which enhanced the mass transfer process. Density Functional Theory (DFT) calculations were conducted to deeply investigate the impact of defect structures on the adsorption mechanism. In addition, breakthrough experiments were conducted to assess the adsorption performance of D-NH2-UiO-66 towards SO2, and the material’s potential application in cultural relic storage environments was explored through controlled laboratory tests. The results indicated that this material possesses outstanding SO2 adsorption performance, effectively improving the integrity of paper fibers and enhancing the tensile strength of the paper. This study not only provides new insights into the application of MOFs materials in environmental protection but also offers an effective solution for the preservation of cultural heritage.
Politics of the Middle East
Authors: El-Mahdi Rabab 
Published: December 2024

Abstract
This article argues that the interplay between a limited disciplinary research agenda in political science and an overemphasis on quantitative methods has left a whole range of important untapped questions regarding the Middle East and North Africa. This is most obvious, when looking at the leading journals of the discipline following the 2011 uprisings. While, there was a short-lived shift toward topics like social mobilization, the scholarship still maintained the primacy of conventional ontological taxonomies such as Islam and democracy as the main pathways to understanding the region. The diversity of issues and the political complexity of the unfolding processes was overshadowed by many of the age-old questions about democratic transitions. At same time an increasing weight given to quantitative and experimental method often times took precedence over the intellectual and political relevance of the research question being asked.
Remnants of Eternal Possibility
Authors: Chubb-Confer Francesca 
Published: December 2024

Abstract
This article presents a new way of considering the poetry of Muhammad Iqbal (d. 1938) by arguing that Iqbal's lyric poetry, particularly the ghazal, should be read as a mode of expression that sets out its own methodology for negotiating the new demands colonial modernity made of the Muslim subject's relationship to tradition. Through a close reading and analysis of a Persian ghazal from Iqbal's 1923 Payām-i Mashriq (Message of/from the East), this article proposes that Iqbal's ghazals offer a lyric method in which the resources of the Persianate poetic tradition navigate these demands on the self and its representation. With an analysis of formal and rhetorical features, mainly apostrophe and the imperative voice, as well as a consideration of Iqbal's philosophy of time and the representation of temporality in the lyric, one can see how the poem reorients the connection between tradition and modernity not as historical trajectory, but as co-constituted in lyric time in an ambivalent, mutually generative relationship.
Longevity of Deep Brain Stimulation in Essential Tremor: A Comparison of Omnidirectional and Directional Leads
Authors: Harland Tessa , Sabourin Shelby , Mayer Ryan , Durphy Jennifer , Adam Octavian , Pilitsis Julie G. 
Published: December 2024

BACKGROUND AND OBJECTIVES:
Patients undergoing thalamic ventral intermediate nucleus stimulation to treat essential tremor (ET) develop tolerance over time, requiring higher stimulation amplitudes that lead to more frequent battery changes and suboptimal tremor control. The study objective is to determine whether amplitude tolerance differs between patients with omnidirectional vs directional leads.

METHODS:
We conducted a retrospective analysis of ET patients with omnidirectional and directional leads implanted between 2005 and 2022. We compared patient demographics, tremor scores, and energy utilization for directional and omnidirectional leads. Contact impedance was used to normalize amplitude values between groups. Analyses were duplicated after reclassifying omnidirectional and directional based on the utilization of directional programming for 2 or more years.

RESULTS:
A total of 24 directional leads in 22 patients and 39 omnidirectional leads in 30 patients were followed for a mean of 3.71 and 7.54 years, respectively. There was no significant difference in age or baseline tremor scores between the groups. Both lead types demonstrated increasing amplitudes over time, but directional leads had significantly less change over time, particularly in the first year (P = .0012). Patients with omnidirectional leads were more likely to experience a pulse width increase of greater than 20 µs over 1 year (41.0% vs 12.5%; P = .035). Although time to first implantable pulse generator replacement was shorter for directional leads, this was not significant (P = .062).

CONCLUSION:
Both omnidirectional and directional deep brain stimulation reduces tremor severity in ET patients. However, directional leads offer more stable voltage requirements and less year-to-year voltage change, particularly in the first year. The increased likelihood of significant pulse width changes in omnidirectional leads suggests that directional leads may provide more sustainable therapeutic effects through other programming parameters. Ongoing research is needed to optimize deep brain stimulation technology and programming strategies to maximize patient benefit and device longevity.
Posterior Inferior Cerebellar Artery Double Reimplantation Bypass for Treatment of a Dolichoectatic Posterior Inferior Cerebellar Artery Aneurysm: A Technical Report
Authors: Hackett Ashia M. , Adereti Christopher O. , Nico Elsa , Scherschinski Lea , Pace Matthew L. , Eberle Adam T. , Malnik Samuel L. , Hartke Joelle N. , Fox Brandon M. , Winkler Ethan A. , Catapano Joshua S. , Lawton Michael T. 
Published: December 2024

BACKGROUND AND IMPORTANCE:
The surgical management of posterior inferior cerebellar artery (PICA) aneurysms often poses a challenge because of tight surgical corridors, proximity to the lower cranial nerves, and the presence of perforators supplying the medulla. This report describes an excision and double reimplantation bypass for treatment of a dolichoectatic PICA aneurysm found on familial screening in a young man with a family history of aneurysmal subarachnoid hemorrhage.

CLINICAL PRESENTATION:
The patient underwent a right far-lateral craniotomy with excision of the dolichoectatic right PICA aneurysm with an additional outflow branch. An end-to-end reanastomosis was performed from the proximal PICA to the larger distal outflow PICA vessel, followed by an end-to-side anastomosis of the second outflow branch to the distal PICA; a salvage bypass with side-to-side V4-p2 reimplantation was later conducted because of thrombus formation at the initial end-to-end reanastomosis.

CONCLUSION:
PICA aneurysms are uncommon and difficult to treat because of their location and complex anatomy, often requiring unique bypass techniques. This case was further complicated by a thrombus formation, which was likely caused by pathological aneurysmal tissue being incorporated in the bypass. This case required an unconventional bypass construct that proved to be effective.
Learning in Repeated Multiunit Pay-as-Bid Auctions
Authors: Galgana Rigel , Golrezaei Negin 
Published: December 2024

Problem definition: Motivated by carbon emissions trading schemes (ETSs), Treasury auctions, procurement auctions, and wholesale electricity markets, which all involve the auctioning of homogeneous multiple units, we consider the problem of learning how to bid in repeated multiunit pay-as-bid (PAB) auctions. In each of these auctions, a large number of (identical) items are to be allocated to the largest submitted bids, where the price of each of the winning bids is equal to the bid itself. In this work, we study the problem of optimizing bidding strategies from the perspective of a single bidder. Methodology/results: Effective bidding in PAB auctions is complex due to the combinatorial nature of the action space. We show that a utility decoupling trick enables a polynomial time algorithm to solve the offline problem where competing bids are known in advance. Leveraging this structure, we design efficient algorithms for the online problem under both full information and bandit feedback settings that achieve an upper bound on regret of [Formula: see text] and [Formula: see text], respectively, where M is the number of units demanded by the bidder, and T is the total number of auctions. We accompany these results with a regret lower bound of [Formula: see text] for the full information setting and [Formula: see text] for the bandit setting. We also present additional findings on the characterization of PAB equilibria. Managerial implications: Although the Nash equilibria of PAB auctions possess nice properties such as winning bid uniformity and high welfare and revenue, they are not guaranteed under no-regret learning dynamics. Nevertheless, our simulations suggest that these properties hold anyways, regardless of Nash equilibrium existence. Compared with its uniform price counterpart, the PAB dynamics converge faster and achieve higher revenue, making PAB appealing whenever revenue holds significant social value—for example, ETSs and Treasury auctions. Funding: R. Galgana and N. Golrezaei were supported in part by the Young Investigator Program Award from the Office of Naval Research [Grant N00014-21-1-2776] and the Massachusetts Institute of Technology Research Support Award. Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2023.0403 .
Learning from Inconsistent Performance Feedback
Authors: Chambers Cassandra R. , Alves Marlon , Aceves Pedro 
Published: December 2024

Organizations and the decision makers within them are increasingly subject to inconsistent performance feedback—feedback that contains elements that are incompatible with each other—which can lead to multiple interpretations of performance feedback. When this occurs, decision makers often recode inconsistent performance feedback as successful and continue with their current strategies, which allows them to avoid any self-threat from negative elements of performance feedback but implies that they do not learn from inconsistent performance feedback because they do not change. In contrast, we explore whether decision makers can learn from inconsistent performance feedback. Leveraging over 10 years of complete behavioral records in an online community and a laboratory experiment, we study how decision makers respond to inconsistent performance feedback stemming from multiple evaluators who do not agree on performance quality. Consistent with prior work, we find that decision makers change their strategies less after inconsistent performance feedback. Departing from prior work, we show a corresponding increase in clarification efforts aimed at better understanding which performance strategies work well. Importantly, clarification efforts mediate improved future performance. Our results suggest that inconsistent performance feedback can trigger deeper learning and enhanced performance, contributing to performance feedback theory and research on the microfoundations of organizational learning. Funding: The authors thank the University of São Paulo, Johns Hopkins University, and SKEMA Business School for institutional and financial support. Supplemental Material: The online appendix is available at https://doi.org/10.1287/orsc.2022.16833 .
Prognostic impact of aetiology in adult hemophagocytic lymphohistiocytosis: insights from an intensive care unit experience
Authors: Noversa de Sousa Rita , Sá Lima Andreia , Viana Susana , Guimarães Filipa , Pereira Marta , Afonso Luís Miguel 
Published: December 2024

Background: Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening hyperinflammatory syndrome marked by excessive immune activation. It can be triggered by various factors, including infections, malignancies, and autoimmune diseases, making the diagnosis challenging due to its overlap with other severe conditions. Case reports: We discuss two intensive care unit (ICU) cases illustrating the diverse manifestations of HLH and the critical importance of early recognition and treatment. The first case involves natural killer-cell leukaemia, and the second, a suspected viral trigger. Both highlight the necessity of a multidisciplinary approach in diagnosis and management, emphasizing the complexity of HLH in ICU settings. Conclusions: High mortality rates, particularly in malignancy-associated HLH, underscore the importance of tailored treatment strategies based on the underlying aetiology.
An overview of diabetes-related foot ulcers
Authors: Gohil Krishna 
Published: December 2024

Diabetes is know to be damaging to the health of patient's feet. This article explains how nurses can assess and manage caused of diabetes-related foot ulcers. The escalating prevalence of diabetes mellitus presents concern due to its widespread organ damage, including the heart, kidneys, eyes, and nerves, leading to severe complications such as heart attacks, strokes, blindness, and diabetes-related foot ulcers (DFUs). Management in the community setting should be focused on prevention, assessment and patient-centred care. By understanding the complex aetiology, risk factors, and classification of DFUs, along with utilising evidence-based interventions like the Wound, Infection and Ischemia (WIfI) system, we can streamline care.