bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metatarsal Aneurysmal Bone Cysts Treated With En Bloc Resection and Reconstruction With Fibular Allograft
Authors: Hajialiloo Sami Sam , Toloue Ghamari Babak , Kargar Shooroki Khalil , Mohammadi Aniloo Fateme , Ammar Wael , Rikhtehgar Masih , Mohammadi Mohammad , Dehghani Firoozabadi Seyed Reza , Nahvizadeh Shima 
Published: December 2024

Background: Treatment of Primary metatarsal aneurysmal bone cyst (ABC) with curettage and bone grafting unfortunately has a high recurrence rate, particularly in short tubular bones. This study presents a 16-year experience treating ABCs in the bones of the foot at an orthopaedic oncology referral center. Treatment involved en bloc resection and reconstruction of the defect with fibular allograft in all cases. Retrospectively collected data were used to document the outcomes. Methods: This retrospective review includes patients with primary metatarsal ABC treated en bloc resection at a single center between 2004 and 2020. Information on the diagnosis, treatment, complications, and outcomes was collected from our database for all eligible patients. Radiologic healing was used as our primary outcome measure. The patient’s function was assessed using the Toronto Extremity Salvage Score (TESS) and Musculoskeletal Tumor Society (MSTS) score. Results: The study included 19 subjects (11 women, 8 men) with a mean age of 18 years (SD 11-35). The average resected length was 4.24 cm (3-6 cm). The mean follow-up time was 79.26 months (28-160 months). The mean TESS score and MSTS were 94.52 and 28.42, respectively. The average healing time was 10.2 weeks. No patient had local recurrence. Arthrodesis was performed in 3 patients because of joint involvement. Repeat surgery was performed for 2 patients, debridement for one because of infection and bone graft for another because of nonunion. One patient had experienced an allograft fracture. Conclusion: Based on the Enneking classification, our experience has shown that a reasonable surgical approach for primary active and invasive metatarsal ABC is en bloc resection and reconstruction with fibula allograft. This method has a low risk of recurrence and does not result in significant functional impairment.
Arteriovenous access creation for hemodialysis patients with superior vena cava occlusion
Authors: Qiuping Luo , Lizhu Jin , Zhiqiang Duan , Jia Hu , Tianlei Cui 
Published: December 2024

Background: The feasibility of creating arteriovenous (AV) access in hemodialysis patients with superior vena cava occlusion (SVCO) is debated due to impaired blood return to the right atrium. However, collateral venous networks may offer an alternative solution, allowing for the creation of peripheral AV access. This study evaluates the outcomes of AV access construction in hemodialysis patients with SVCO. Methods: A retrospective review of 18 patients with SVCO and patent azygous veins was conducted between August 2021 and June 2023. These patients underwent peripheral AV access creation, including fistulas and grafts. Collected data included baseline demographics, preoperative 3D CT reconstruction of thoracic vessels, central venography, vascular access types, surgical details, postoperative complications, and the timing and methods of interventions. Results: AV access was successfully created in all patients, including 15 AV fistulas and 3 AV grafts. The average brachial blood flow rate before cannulation was 848.67 ± 132.03 mL/min. The median follow-up period was 18.5 months (range: 10–32 months). During follow-up, six patients required interventions, such as flow reduction or percutaneous transluminal angioplasty, to optimize blood flow or resolve venous obstruction. Two cases were classified as failed access at 10 and 18 months post-creation. One patient transitioned to peritoneal dialysis due to AVG dysfunction, while the other underwent bypass surgery for chylothorax. Conclusion: AV access can be successfully created and maintained in patients with SVCO and a patent azygous vein. Although mild venous obstruction symptoms may develop during follow-up, timely intervention can preserve access patency. For patients with limited vascular resources and challenging catheterization, this approach represents a viable option for establishing effective access.
Development and validation of a tool for ambulatory monitoring of peripherally inserted central catheter-associated complications
Authors: Sofie Segers , Jodie Langbeen , Stijn Blot , Wim Terryn , Mieke Debrauwere , Dirk Vogelaers 
Published: December 2024

Introduction: Peripherally inserted central catheters (PICC) are the preferred vascular access for Outpatient Parenteral Antimicrobial Therapy (OPAT) due to user-friendliness and high safety level. Nevertheless, the lack of a validated tool hampers the yet ill-charted epidemiology and monitoring of PICC related complications in ambulatory care. Methods: A sequential exploratory mixed-method three phase research design was used to develop and validate a monitoring tool for PICC complications in OPAT. A literature review and co-design approach allowed its development, followed by Delphi panel content validation. In a third phase, the tool was piloted and implemented for further evaluation, including adherence. Results: Twelve and nine experts respectively participated in the first and second Delphi round (response rate: 92% resp. 69%). Scale-level Content Validity Index based on the Average Method was 0.99 and 0.90 in the first and the second Delphi round respectively. After the Delphi procedure, the tool consisted of the following relevant items: (1) functionality (injection and aspiration), (2) insertion site, (3) catheter fixation, (4) infection and (5) thrombosis. After positive pilot testing, the tool was implemented in 17 participants with outcomes measured in 15 participants. Two participants were readmitted and three experienced PICC complications. As for adherence, the monitoring tool was partially or fully completed 285 times (74,8%); external catheter length was rarely or never reported and systematic follow-up of the temperature scored poorly. Conclusion: A tool for ambulatory monitoring of PICC-associated complications with a solid content validity was obtained. Future research should consist of a multicentric larger size assessment and digitalization.
Unmet need for and barriers to receiving health care and social welfare services in Finland
Authors: Ilmarinen Katja M. , Aalto Anna-Mari , Muuri Anu L. 
Published: December 2024

Aim: Need-based access to health care and social welfare services is an element of health promotion, and it endorses equity and the principles of universalism in society. To explore access to services, this study analyses unmet need for services, barriers that impede access and whether individual characteristics are associated with service access. The study period coincided with the COVID-19-pandemic and health and social services reform in Finland. Method: The prevalence of subjective unmet need was used as an indicator of service access. Inconvenient opening hours, a difficult journey to the service unit and high user fees were barriers to receiving services. A nationally representative FinSote survey 2018 and 2020 was used in the analyses. Data were examined with multivariate logistic regression models using SPSS. Results: A high prevalence of unmet need for health care and especially for social welfare services was observed. The prevalence of unmet need increased from 2018 to 2020, but in health care only, and access to social welfare services deteriorated. In particular, women, younger people, those who need income support and those with poor health or quality of life forgo care. Conclusions: A considerable share of the Finnish population do not receive essential services according to need and face barriers in accessing services. Individual characteristics are associated with perceived unmet need and access barriers despite the ethos of equal opportunities. COVID-19 measures are likely to have worsened the situation. Actions to improve access must urgently be implemented to achieve the policy goals of health promotion, equity in health and universalism.
Fibular nails versus hindfoot nails in the management of ankle fractures with soft tissue injury in the elderly – a preliminary study
Authors: Mahmood Aatif , Piper Danielle , Alagbe Basit , Hawkes David , Marsh Alastair , Fenton Paul 
Published: December 2024

Introduction Fragility ankle fractures are becoming increasingly common with an ageing population. Underlying co-morbidities, osteoporosis and a poor soft tissue envelope makes their management challenging. Purpose The aim of this study was to compare the results of fibular nail (FN) versus hindfoot nail (HFN) for the treatment of fragility ankle fractures. Patients and Methods This was a retrospective comparative study from a level 1 trauma centre. All patients over the age of 60 with a low energy fragility ankle fracture between January 2017 and February 2021 were included in the study. Primary outcome was Olerud-Molander ankle score. Secondary outcomes were postoperative complications and re-operation rates. Mean follow-up was 6.2 months. Results Fifty six patients were identified with a mean age of 74 years. Time to radiographic union rate was not significantly different between both groups (p = 0.626). No cases of non-union or malunion were identified. The mean Olerud-Molander ankle score was significantly higher in FN group (p < 0.01). There was a higher wound complication rate in the HFN group (p = 0.04). The incidence of reoperation did not significantly differ between both groups (p = 0.118). Conclusion Hindfoot nails and fibular nails can lead to equivalent union rates. However, better functional outcomes and reduced complication rate are observed after fibular nails.
Iatrogenic cervical artery dissections during endovascular interventions
Authors: Xeros Helena , Bucak Bilal , Oushy Soliman , Lanzino Giuseppe , Keser Zafer 
Published: December 2024

Background Iatrogenic cervical artery dissection (CeAD) results from various procedures including interventional angiographic procedures and diagnostic angiography. Iatrogenic CeAD is rare, resulting in limited literature on management and outcomes. This observational cohort study investigates approaches and outcomes of iatrogenic CeAD after endovascular interventions. Methods We conducted a retrospective review for patients who underwent endovascular intervention with resulting iatrogenic CeAD at Mayo Clinic, Rochester, MN, from 1998 to 2021. Pertinent patient factors were extracted and descriptive statistics generated. Results Between 1998 and 2021, 21,191 patients underwent catheter-based cerebral angiography. Thirty-two had iatrogenic CeADs (23 women; median age 59 [range 40.5–92.9]). Common comorbidities included hypertension (62.5%), smoking (56.3%), and hyperlipidemia (46.9%). Nine (28.1%) had dissection with diagnostic angiograms, 6 (18.8%) endovascular thrombectomy, 15 (46.9%) intracranial aneurysm treatment/coiling, and 2 (6.3%) intracranial angioplasty with/without stenting. All dissections were diagnosed by cerebral angiography during the same session as initial interventions. Four (12.5%) underwent hyperacute stenting. Thirty (93.7%) were placed on antithrombotic therapy with aspirin alone (34.4%) or dual-antiplatelet therapy with aspirin and clopidogrel (37.5%). Median duration of acute treatment was three months. Follow-up imaging showed excellent radiological course. Conclusions Iatrogenic CeAD with endovascular interventions is rare and typically benign. Most are managed medically without complications or long-term negative outcomes. Oral single or dual-antiplatelet therapies are preferred compared to previous studies which emphasize intravenous anticoagulation. The duration of acute therapy varied from three months to lifelong. Key factors influencing clinical decision-making may include occlusion rate, pseudoaneurysm formation, intracranial extension, distal collateral circulation, and resultant ischemia.
Addressing complications of large bore access in endovascular and cardiovascular procedures: An illustration of treatment options
Authors: Mukherjee Dipankar , Amatya Bibhas , Lirag Melissa , Bernardo Nelson 
Published: December 2024

Background Endovascular procedures requiring large bore access, such as Transcatheter Aortic Valve Replacement (TAVR), Thoracic Endovascular Aortic Repair (TEVAR), and Endovascular Aneurysm Repair (EVAR), have become increasingly common. Despite advancements, complications from these procedures pose clinical challenges, especially in elderly and frail patients. The clinical objective of this paper is to demonstrate the complexities and innovative management strategies for complications that arise from large bore access. Case Report This report presents two cases illustrating percutaneous management of complications arising from large bore access during endovascular interventions. The first case involves a 74-year-old Asian female with a history of type A aortic dissection, who underwent TEVAR using a Gore TBE endograft. Post-procedure, the patient developed hemorrhagic shock due to disruption of the right external iliac artery. Interventions included upsizing the left femoral artery sheath, CODA balloon inflation in the distal aorta, and deployment of multiple VBX stents. The second case features a 24-year-old Caucasian female with a large pseudoaneurysm at the cannulation site in the aortic arch following a heart transplant. Successful TEVAR was performed to exclude the pseudoaneurysm. Closure of the right femoral artery access using 6 French ProGlide sutures was complicated, requiring balloon angioplasty to create an opening in the common femoral artery. Conclusions These cases highlight the challenges and innovative strategies in managing complications associated with large bore access during endovascular procedures. Insights gained from these experiences contribute to the armamentarium of interventionists, offering valuable guidance in addressing similar scenarios.
Danshensu and Notoginsenoside R1 Combination Alleviates Obesity in Mice Via Modification of Gut Microbiota and Short-Chain Fatty Acids
Authors: Tao Huijuan , Wang Wenxiao , Cao Hui , Tong Ning , Ma Li , Shen Jie , Zhang Qiao , Tang Yuping , Yue Shijun 
Published: December 2024

Objectives The current study evaluated the protective mechanism of Danshensu and Notoginsenoside R1 combination (DR1) on obesity from the perspective of gut microbiota and short-chain fatty acids (SCFAs). Methods Male C57BL/6J mice were fed either a normal diet or a high-fat diet (HFD). DR1 (60 mg/kg) was administered to both normal and HFD-induced obese mice for 12 weeks. The obese phenotype and pharmacodynamics effects were assessed through hematoxylin-eosin staining of epididymal fat, liver, small intestine, and colon tissues, as well as serum biochemical detection. Moreover, 16S ribosomal ribonucleic acid (16S rRNA) sequencing was employed to profile the taxonomy and function of gut microbiota, while SCFAs were quantified using ultra-performance liquid chromatography coupled with mass spectrometry methods. Results Compared to HFD group, the tissue lesions were significantly alleviated by DR1 treatment in obese mice, accompanied by the significant reduction of average body, epididymal fat and liver weights, as well as the normalization of insulin sensitivity and glucose homeostasis ( P < .05, P < .01 or P < .001). 16S rRNA sequencing analysis showed that DR1 treatment potently ameliorated HFD-induced dysbiosis of gut microbial composition and function. Notably, DR1 reversed the ratio of Firmicutes/ Bacteroidetes to normality. Moreover, DR1 improved intestinal barrier structures and enhanced SCFAs concentrations in the caecal contents (especially propionate and butyrate). Conclusion These results suggested that DR1 could reverse the gut microbial dysbiosis and increased SCFAs levels in HFD-induced obese mice, thereby ultimately supporting the anti-obesity value of DR1.
Allelopathic Effects of Nech Bahirzaf (Eucalyptus globulus Labill.) on Germination and Seedling Growth of Crops
Authors: Mekonnen Amare Bitew , Seid Ali , Wassie Wubetie Adnew 
Published: December 2024

Objectives The objective of this study was to test the alleopathic effects of E. globulus leaves and litter fall aqueous extracts on germination and growth of Winter Wheat (Triticale hexaploide), Barley ( Hordeum vulgare), and Maize ( Zea mays) crops. Methods Allelopathic potential of Eucalyptus globulus on germination and seedling growth of Maize ( Zea mays), Winter Wheat ( Triticale hexaploide), and Barley ( Hordeum vulgare) was studied under laboratory conditions. Aqueous extracts of young tree leaves, old tree leaves, and litter fall of E. globulus were prepared. Filtered extracts were used to treat germinating seeds of test crops. Open and undercanopy soils collected from different depths were also tested for allelopathic effects. ANOVA was used to analyze data in SAS software. Means were compared using Tukey's HSD test at the 5% level of significance. Results The result indicated that the extracts of E. globulus had a significant inhibitory effect on germination and seedling growth of the test crops. The highest effect of extracts was observed from old tree leaves, followed by young tree leaves, and the least from litter fall. Among the three crops, Z. mays found to be more sensitive than others. However, the undercanopy soils did not show any allelopathic effect on test crops. Conclusion We concluded that E. globulus allelochemicals do not accumulate in soils and the crops can develop adaptation through time. Thus, use of E. globulus for agro-forestry with removal of fallen leaves before cultivation is recommended.
Antibacterial Activity and Chemical Characterization of Peel Essential Oil of Citrus Nagato-Yuzukichi Tanaka and Its Constituents
Authors: Imahori Daisuke , Umeda Satoshi , Kubota Miharu , Muraoka Takuya , Yoshimi Yoji , Oie Shigeharu , Tanaka Hiroyuki 
Published: December 2024

Background The uncontrolled use of antimicrobial drugs has led to the widespread of drug-resistant microbes such as MRSA, which has been regarded as clinically important problem. The essential oil is that some can be developed as natural antibiotics. Antibacterial activity of the Citrus spp. against the resistant and susceptible strains of S. aureus has been reported. However, to date, information on the phytochemical and bioactive characterization of the of C. nagato-yuzukichi essential oil (CNEO) in scarce. Purpose this study aimed to evaluate chemical composition, antibacterial activity against MSSA, MRSA, and E. coli, of the CNEO and their major components. Additionally, we determined their association with vancomycin and antibiofilm activity against MRSA strain of CNEO and their major components. Study design and Method In this work, the composition of CNEO was determined by GC-MS. Disk diffusion method, agar plate dilution method, MIC, MBC, checkerboard assay, and biofilm growth method were determined to assess their antibacterial activities. Results GC-MS analysis revealed 99.73% of the constituents of CNEO. The major components of CNEO were d-limonene (60.06%), γ-terpinene (8.40%), β-phellandrene (7.31%), α-terpineol (3.14%), and β-myrcene (2.34%). CNEO showed antibacterial activities against MRSA (DIZ: 26.78 mm, MIC: 16 mg/mL), with a similar trend to d-limonene (DIZ: 17.42 mm, MIC: 128 mg/mL) and α-terpineol (DIZ: 19.40 mm, MIC: 2 mg/mL). In combination effect, the results showed the additive interaction of vancomycin with CNEO and α-terpineol on the MRSA (FIC indexes: 0.5 < to ≤1.0). Conclusion The integrated analysis in the present study suggested that CNEO or its major components components may be a promising alternative therapy to antibiotic-resistant bacterial infections.
Resting energy expenditure: Is there any difference between dialysis and non-dialysis dependent chronic kidney disease patients?
Authors: Yasar Emre , Tek Nilüfer Acar , Tekbudak Merve Yasemin , Yurtdaş-Depboylu Gamze , Deveci-Bulut Tuba Saadet , Özbaş Burak , Bayazit Ayşe Derya , Güneş Burcu Deniz , Erten Yasemin 
Published: December 2024

Background Energy imbalance can be caused by several clinical conditions commonly found in advanced CKD and end-stage renal disease (ESRD), resulting in nutritional deficiencies. Objective We aimed to investigate whether there is a difference in resting energy expenditure (REE) between patients with ESRD undergoing HD or PD and those with non-dialysis-dependent chronic kidney disease (NDD-CKD) and also to evaluate the relationship among REE and possible factors that might affect REE. Methods We included 29 patients undergoing HD, 29 patients undergoing PD, and 29 patients with stage 3–5 NDD-CKD. FFM was estimated using multifrequency bioimpedance analysis. REE was evaluated with indirect calorimetry. The serum level of Interleukin-6(IL-6) was measured using the chemiluminescence immunoassay technique. REE was normalized for FFM via the REE/FFM ratio. Results The study included 45(52%) females. A total of 87 patients were included in the study. The mean age of the patients was 50 ± 12 years. REE/FFM ratio was higher in the HD group than in the PD ( p = 0.031) and NDD-CKD ( p = 0.002) groups. IL-6 was higher in the HD group than the NDD-CKD group ( p = 0.004) and similar in the HD and PD groups ( p = 0.089). REE/FFM ratio was positively correlated with IL-6 (r = 0.47, p < 0.001). Age, IL-6, and HD predicted REE/FFM ratio (F = 7.763, p < 0.001). In the analysis performed by including HD and PD patients, gender and HD were effective in predicting REE/FFM ratio (F = 3.315, p = 0.011). Conclusions REE was to be higher in the HD group than in the PD and NDD-CKD groups. The fact that HD patients have a higher REE than the NDD-CKD group may be explained by the higher IL-6 level. Further studies are needed to identify factors that may cause HD patients to have a higher REE than PD patients.
Unraveling dental caries misinformation: Identifying predictive factors for engagement on Instagram
Authors: Menezes Tamires Sá , Jucá Ana Maria , Jorge Olívia Santana , Lotto Matheus , Ayala Aguirre Patricia Estefania , Cruvinel Thiago 
Published: December 2024

Objective This study aimed to identify predictive factors for engagement with dental caries-related posts on Instagram. Methods Using CrowdTangle, 10,000 English-language posts were retrieved based on total interactions. From these, 2063 posts were evaluated using predetermined inclusion criteria, and a final sample of 500 posts was selected. Two independent investigators classified the posts according to dichotomized criteria: author profile (regular or commercial users), sentiment (positive or neutral/negative), motivation (financial or nonfinancial), format (link or photo), aim of content (prevention or treatment), and facticity (information or misinformation). Predictive factors for total interaction and overperforming scores were determined using multiple logistic regression models. Results Misinformation accounted for 44% of posts. Most posts were shared by regular users (67.8%), used a photo format (61%), and expressed a positive sentiment (73.8%). Prevention-related posts were significantly related to financial motivation, while treatment-related posts were linked to time of publication, neutral/negative sentiment, and photo format. Older posts were positively associated with misinformation (odds ratio (OR) = 1.45). Positive sentiment (OR = 1.71) and regular user profiles (OR = 1.93) were associated with higher total interactions. In contrast, business profiles (OR = 2.39) and posts with neutral/negative sentiment (OR = 1.79) were associated with overperforming scores. Conclusion Despite a significant amount of misinformation, only sentiment and author profiles were predictive factors for total interaction and overperforming scores in Instagram posts about dental caries.