bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metal–insulator transition tuned by oxygen vacancy migration across TiO2/VO2 interface
Authors: Lu Qiyang , Sohn Changhee , Hu Guoxiang , Gao Xiang , Chisholm Matthew F. , Kylänpää Ilkka , Krogel Jaron T. , Kent Paul R. C. , Heinonen Olle , Ganesh P. , Lee Ho Nyung 
Published: October 2020

AbstractOxygen defects are essential building blocks for designing functional oxides with remarkable properties, ranging from electrical and ionic conductivity to magnetism and ferroelectricity. Oxygen defects, despite being spatially localized, can profoundly alter global properties such as the crystal symmetry and electronic structure, thereby enabling emergent phenomena. In this work, we achieved tunable metal–insulator transitions (MIT) in oxide heterostructures by inducing interfacial oxygen vacancy migration. We chose the non-stoichiometric VO2-δ as a model system due to its near room temperature MIT temperature. We found that depositing a TiO2 capping layer on an epitaxial VO2 thin film can effectively reduce the resistance of the insulating phase in VO2, yielding a significantly reduced ROFF/RON ratio. We systematically studied the TiO2/VO2 heterostructures by structural and transport measurements, X-ray photoelectron spectroscopy, and ab initio calculations and found that oxygen vacancy migration from TiO2 to VO2 is responsible for the suppression of the MIT. Our findings underscore the importance of the interfacial oxygen vacancy migration and redistribution in controlling the electronic structure and emergent functionality of the heterostructure, thereby providing a new approach to designing oxide heterostructures for novel ionotronics and neuromorphic-computing devices.
Double-in vitro maturation increases the number of vitrified oocytes available for fertility preservation when ovarian stimulation is unfeasible
Authors: Sermondade Nathalie , Grynberg Michaël , Comtet Marjorie , Valdelievre Constance , Sifer Christophe , Sonigo Charlotte 
Published: October 2020

AbstractWhen ovarian stimulation is unfeasible, in vitro maturation (IVM) represents an alternative option for fertility preservation (FP). This retrospective study aims to evaluate the feasibility of performing within a short time frame two IVM cycles for FP. Seventeen women with breast cancer, 18–40 years of age, having undergone 2 cycles of IVM followed by oocyte vitrification were included. Non parametric analyses were used. No difference was observed between IVM1 and IVM2 outcomes. No complication was reported. The respective contributions of IVM1 and IVM2 for the number of cryopreserved oocytes were comparable irrespective of the delay between both procedures, even when performed during the same menstrual cycle. Those findings suggest that repeating IVM cycles may constitute a safe option for increasing the number of vitrified mature oocytes for FP. These two retrievals may be performed during the same cycle, providing additional argument for a physiologic continuous recruitment during follicular development.
The influence of the Kinesio Taping on selected ultrasonography measurements, and quality of life in patients with rotator cuff lesions
Authors: Bac Aneta , Wróbel Magdalena , Ogrodzka-Ciechanowicz Katarzyna , Michalik Edyta , Ścisłowska-Czarnecka Anna 
Published: October 2020

AbstractThe assessment of the six-week influence of Kinesio Taping combined with a rehabilitation on selected ultrasonography measurements, the level of disability, and the quality of life in patients with rotator cuff lesions. 60 participants were randomly assigned into a taping group (KT combined with a six-week rehabilitating protocol) and a control group (only rehabilitation protocol). In all patients the following assessments were performed twice: USG, UEFI and NHP questionnaires. In the examination of the subacromial space and the subacromial bursa in the taping group, no statistical significance was observed. A statistically significant change in the thickness of the muscles was obtained only for the thickness of the infraspinatus in the taping group. A statistically significant change was obtained in the assessment of tendinopathy only for the supraspinatus muscle in both groups. Within both groups a statistically significant difference was observed in the average UEFI and NHP scores; however, the differences in the scores obtained between the groups were not statistically significant. The use of KT with a rehabilitation program did not yield statistically significantly better results in the improvement of selected shoulder region indicators, the function of the upper limb and the quality of life.
A wearable heart rate measurement device for children with autism spectrum disorder
Authors: Fioriello Francesca , Maugeri Andrea , D’Alvia Livio , Pittella Erika , Piuzzi Emanuele , Rizzuto Emanuele , Del Prete Zaccaria , Manti Filippo , Sogos Carla 
Published: October 2020

AbstractAutism spectrum disorder (ASD) is a neurodevelopmental condition characterized by early impairment in social and communication domains and autonomic nervous system unbalance. This study evaluated heart rate (HR) as a possible indicator of stress response in children with ASD as compared to children with language disorder (LD). Twenty-four patients [mean age = 42.62 months; SD = 8.14 months,12 with ASD (10 M/2F) and 12 with LD (8 M/4F)] underwent clinical [Leiter International Performance Scale-Revised, Autism Diagnostic Observation Schedule, second edition (ADOS-2)] and physiological evaluation (HR monitoring) during five interactive activities, while wearing an HR measurement device. IQ (ASD:IQ = 103.33 ± 12.85 vs. LD:IQ = 111.00 ± 8.88, p = 0.103) and fluid reasoning on the Leiter-R Scale were within the normal range in all subjects. Increased HR during the third activity (ADOS-2 bubble play) significantly correlated with autistic symptoms (r = 0.415; p = 0.044), while correlations between ADOS-2 total score and HR during the first activity (ADOS-2 free play; r = 0.368; p = 0.077), second activity (Leiter-R figure ground subscale; r = 0.373, p = 0.073), and fifth activity (ADOS-2 anticipation of a routine with objects; r = 0.368; p = 0.076) did not quite reach statistical significance. Applying a linear regression model, we found that the ADOS-2 total score significantly influenced HR variations (p = 0.023). HR monitoring may provide a better understanding of the stress-provoking situations for children with ASD. Furthermore, it could help clinicians detect the impact of the stressful condition on the autistic core and adress treatment strategy.
Fracturing in coals with different fluids: an experimental comparison between water, liquid CO2, and supercritical CO2
Authors: Yang Jianfeng , Lian Haojie , Li Li 
Published: October 2020

AbstractThe present work conducted laboratory experiments of fracturing in fat coals, anthracites, and mudstones. Three different fluids were selected as the fracturing fluids, including water, liquid CO2 (L-CO2), and supercritical CO2 (Sc-CO2). The resulting fracture morphologies and fracture apertures of the coal specimens were investigated using 3D morphological scanning, and the permeabilities of the samples were measured before and after fracturing. The experimental results showed that the breakdown pressures of Sc-CO2 fracturing were the lowest among the three fracturing fluids, and the average single fracture apertures of the ScCO2-induced cracks were the smallest amongst the three fracturing fluids. In addition, the number of cracks and the roughness coefficients induced by Sc-CO2 fracturing were larger than those caused by water and liquid CO2. The viscosity of the fracturing fluid and the capillary effect are key factors that affect the crack propagation path and fracture surface topography. The results suggest that Sc-CO2 has the largest diffusion length, and thus is capable of permeating the coal matrix through small pores and causing more extensive fractures. Additionally, the effective hydraulic apertures of coal specimens produced by Sc-CO2 fracturing were wider than those induced by water and liquid CO2. The experimental results indicate that Sc-CO2 fracturing has huge potential to enhance coalbed methane recovery.
The correlation between plasma total homocysteine level and gestational diabetes mellitus in a Chinese Han population
Authors: Deng Mengyao , Zhou Jia , Tang Zhao , Xiang Jun , Yi Jing , Peng Yushuang , Di Lihua , Zhai Xiaobing , Yang Mei , Du Yukai 
Published: October 2020

AbstractTo assess the correlation between plasma total homocysteine (tHcy) level and gestational diabetes mellitus (GDM) in a Chinese Han population. This case–control study included 350 GDM patients and 346 gestational week-matched normal glucose tolerance (NGT) pregnant women. Plasma tHcy and insulin levels were analyzed by HPLC and ELISA respectively. Logistic regression analysis was used to investigate the correlation between plasma tHcy level and risk of GDM. Women with GDM had a higher plasma tHcy level than NGT women (6.61 ± 1.32 vs. 6.17 ± 1.29 μmol/L, P = 0.001)). The GDM risk was 1.79 (OR = 1.79, 95% CI 1.18–2.72, P = 0.006) times higher in women whose plasma tHcy level was ≥ 7.29 μmol/L compared to women with plasma tHcy level < 5.75 μmol/L. Stratified analysis showed the GDM risk were much higher when HOMA-IR index ≥ 2 (OR = 5.42, 95% CI 2.51–11.74, P < 0.001), age ≥ 30 years (OR = 5.14, 95% CI 2.78–9.52, P < 0.001), or women with a family history of type 2 diabetes mellitus (T2DM) (OR = 4.13, 95% CI 1.78–9.56, P = 0.001). In the Chinese Han population, an elevated plasma tHcy level may increase the overall risk of GDM especially in women with a high HOMA-IR index, increasing age or with family history of T2DM.
Impact of metallothionein-knockdown on cisplatin resistance in malignant pleural mesothelioma
Authors: Borchert Sabrina , Suckrau Pia-Maria , Walter Robert F. H. , Wessolly Michael , Mairinger Elena , Steinborn Julia , Hegedus Balazs , Hager Thomas , Herold Thomas , Eberhardt Wilfried E. E. , Wohlschlaeger Jeremias , Aigner Clemens , Bankfalvi Agnes , Schmid Kurt Werner , Mairinger Fabian D. 
Published: October 2020

AbstractMalignant pleural mesothelioma (MPM) is a rare, but aggressive tumor with dismal prognosis. Platinum-based chemotherapy is regularly used as part of multimodality therapy. The expression of metallothioneins (MT) has been identified as a reason for cisplatin resistance, which often leads to early therapy failure or relapse. Thus, knockdown of MT expression may improve response to cisplatin treatment. The MT gene- and protein expression of the MPM-cell lines MSTO-211H, NCI-H2052 and NCI-H2452 and the human fibroblast cell line MRC-5, as well as their sensitivity to cisplatin treatment have been evaluated. Knockdown of MT1A, 1B and 2A expression was induced by RNA interference. MT expression was measured using quantitative real-time PCR. An in vitro Assay based on enzyme activity was used to detect cell viability, necrosis and apoptosis before and after incubation with cisplatin. MT2A gene expression could be detected in all MPM cell lines, showing the highest expression in NCI-H2452 and NCI-H2052, whereas gene expression levels of MT1A and MT1B were low or absent. The immunohistochemically protein expression of MT-I/II reflect MT2A gene expression levels. Especially for MSTO-211H cell presenting low initial MT2A levels, a strong induction of MT2A expression could be observed during cisplatin treatment, indicating a cell line-specific and platin-dependent adaption mechanism. Additionally, a MT2A-dependent cellular evasion of apoptosis during cisplatin could be observed, leading to three different MT based phenotypes. MSTO-211H cells showed lower apoptosis rates at an increased expression level of MT2A after cisplatin treatment (from sixfold to fourfold). NCI-H2052 cells showed no changes in MT2A expression, while apoptosis rate is the highest (8–12-fold). NCI-H2452 cells showed neither changes in alteration rate of MT2A expression nor changes in apoptosis rates, indicating an MT2A-independent resistance mechanism. Knockdown of MT2A expression levels resulted in significantly induced apoptotic rates during cisplatin treatment with strongest induction of apoptosis in each of the MPM cell lines, but in different markedness. A therapeutic meaningful effect of MT2A knockdown and subsequent cisplatin treatment could be observed in MSTO-211H cells. The present study showed MT2A to be part of the underlying mechanism of cisplatin resistance in MPM. Especially in MSTO-211H cells we could demonstrate major effects by knockdown of MT2A expression, verifying our hypothesis of an MT driven resistance mechanism. We could prove the inhibition of MT2A as a powerful tool to boost response rates to cisplatin-based therapy in vitro. These data carry the potential to enhance the clinical outcome and management of MPM in the future.
Chronic rhinosinusitis and premorbid autoimmune diseases: a population-based case–control study
Authors: Shih Liang-Chun , Hsieh Hua-Hsin , Tsay Gregory J. , Lee Ivan T. , Tsou Yung-An , Lin Cheng-Li , Shen Te-Chun , Bau Da-Tian , Tai Chih-Jaan , Lin Chia-Der , Tsai Ming-Hsui 
Published: October 2020

AbstractEvidence shows that chronic rhinosinusitis (CRS) is associated with prior presence of autoimmune diseases; however, large-scale population-based studies in the literature are limited. We conducted a population-based case–control study investigating the association between CRS and premorbid autoimmune diseases by using the National Health Insurance Research Database in Taiwan. The CRS group included adult patients newly diagnosed with CRS between 2001 and 2013. The date of diagnosis was defined as the index date. The comparison group included individuals without CRS, with 1:4 frequency matching for gender, age, and index year. Premorbid diseases were forward traced to 1996. Univariate and multivariate logistic regression was performed to estimate odds ratios (ORs) and 95% confidence intervals. The CRS group consisted of 30,611 patients, and the comparison group consisted of 122,444 individuals. Patients with CRS had a higher significant association with premorbid autoimmune diseases (adjusted OR 1.39 [1.28–1.50]). Specifically, patients with CRS had a higher significant association with ankylosing spondylitis, polymyositis, psoriasis, rheumatoid arthritis, sicca syndrome, and systemic lupus erythematosus (adjusted OR 1.49 [1.34–1.67], 3.47 [1.12–10.8], 1.22 [1.04–1.43], 1.60 [1.31–1.96], 2.10 [1.63–2.72], and 1.69 [1.26–2.25]). In subgroup analysis, CRS with and without nasal polyps demonstrated a significant association with premorbid autoimmune diseases (adjusted OR 1.34 [1.14–1.58] and 1.50 [1.38–1.62]). In addition, CRS with fungal and non-fungal infections also demonstrated a significant association with premorbid autoimmune diseases (adjusted OR 2.02 [1.72–2.49] and 1.39 [1.28–1.51]). In conclusion, a significant association between CRS and premorbid autoimmune diseases has been identified. These underlying mechanisms need further investigation.
Naturally occurring van der Waals materials
Authors: Frisenda Riccardo , Niu Yue , Gant Patricia , Muñoz Manuel , Castellanos-Gomez Andres 
Published: October 2020

AbstractThe exfoliation of two naturally occurring van der Waals minerals, graphite and molybdenite, arouse an unprecedented level of interest by the scientific community and shaped a whole new field of research: 2D materials research. Several years later, the family of van der Waals materials that can be exfoliated to isolate 2D materials keeps growing, but most of them are synthetic. Interestingly, in nature, plenty of naturally occurring van der Waals minerals can be found with a wide range of chemical compositions and crystal structures whose properties are mostly unexplored so far. This Perspective aims to provide an overview of different families of van der Waals minerals to stimulate their exploration in the 2D limit.
Opioid-Induced Hearing Loss and Neonatal Abstinence Syndrome: Clinical Considerations for Audiologists and Recommendations for Future Research
Authors: Rigg Khary K. , Rigg Malika S. 
Published: October 2020

Purpose
Over the last two decades, the number of Americans misusing opioids has reached epidemic levels. With such drastic increases in opioid misuse, audiologists are more likely to have patients with opioid-induced hearing loss or neonatal abstinence syndrome (NAS) than in previous years. More attention is needed on how these increases might influence clinical practice and such a discussion could be useful for audiologists. The goal of this article, therefore, is to summarize what is currently known regarding the relationship between opioid misuse and audiology to help guide hearing health care providers (with a particular focus on opioid-induced hearing loss and NAS). This article (a) summarizes the overlap in opioid misuse and hearing loss populations, (b) describes the evidence linking opioid misuse to hearing loss, (c) discusses clinical implications that opioid-induced hearing loss and NAS have for practicing audiologists, and (d) recommends directions for future audiological research on opioid-induced hearing loss and NAS.

Conclusions
There is considerable overlap between populations at-risk for hearing loss and opioid misuse. Additionally, compelling evidence exists linking opioid misuse to hearing loss, but the specific causal mechanisms remain unclear, indicating a need for additional research. This article attempts to fill a gap in the audiological literature and has the potential to serve as a guide for hearing health care providers to make more informed clinical decisions regarding patients with opioid-induced hearing loss and NAS. Clinicians may wish to consider the concerns raised in this article before intervening with such concerns, especially in the absence of best practice protocols.
Superoscillations and the quantum potential
*
Authors: Berry M V 
Published: October 2020

Abstract
For quantum or other waves that are band-limited, the quantum potential in the Madelung–Bohm representation vanishes on the boundaries of regions where the waves are superoscillatory (i.e. where they vary faster than any of their Fourier components). This connection is illustrated by calculations of the quantum potential zeros for a superoscillatory superposition of plane waves, and by Aharonov–Bohm waves.
Edible mushroom (Flammulina velutipes) as biosource for silver nanoparticles: from synthesis to diverse biomedical and environmental applications
Authors: Faisal Shah , Khan Muhammad Aslam , Jan Hasnain , Shah Sajjad Ali , Abdullah  , Shah Sumaira , Rizwan Muhammad , Wajidullah  , Akbar Muhammad Taj , Redaina  
Published: October 2020

Abstract
The current study reports advanced, ecofriendly and biosynthesized silver NPs for diverse biomedical and environmental applications using Flammulina velutipes as biosource. In the study, a simple aqueous extract of F. velutipes was utilized to reduce the AgNO3 into stable elemental silver (Ag0) at a nanometric scale. The NPs had average size of 21.4 nm, spherical morphology, and were highly stable and pure. The characterized nanoparticles were exploited for a broad range of biomedical applications including bacteriocidal, fungicidal, leishmanicidal, in vitro antialzheimer’s, antioxidant, anti-diabetic and biocompatibility studies. Our findings showed that F. velutipes mediated AgNPs exhibited high activity against MDR bacterial strains and spore forming fungal strains. All the tested urinary tract infection bacterial isolates, were resistant to non-coated antibiotics but by applying 1% of the synthesized AgNPs, the bactericidal potential of the tested antibiotics enhanced manifolds. The NPs also exhibited dose-dependent cytotoxic potential against Leishmania tropica with significant LC50 of 248 μg ml−1 for promastigote and 251 μg ml−1 for amastigote forms of the parasite. Furthermore, promising antialzheimer and antidiabetic activities were observed as significant inhibition of α-amylase, α-glucosidase, acetylcholinesterase (AChE) and butrylcholineterase (BChE) were noted. Moreover, remarkable biocompatible nature of the particles was found against human red blood cells. The biosynthesized AgNPs as photocatalyst, also resulted in 98.2% degradation of indigo carmine dye within 140 min. Owing to ecofriendly synthesis, biosafe nature and excellent physicochemical properties F. velutipes AgNPs can be exploited as novel candidates for multifaceted biomedical and environmental applications.
Comparison between the use of acceleration sensor and video tracker on smartphone for spring oscillation experiment
Authors: Listiaji Prasetyo , Darmawan Melissa Salma , Daeni Fitri , Karmuji  
Published: October 2020

Abstract
Nowadays, mechanical experiments such as spring oscillations for high schools and colleges have been developed using smartphones. This study aims to compare the use of acceleration sensors and video tracker available on smartphones for free and damped spring oscillation experiments. This experiment used varying load masses. In experiments using acceleration sensors, acceleration versus time data were obtained, while experiments using a video tracker got position versus time data. The data were then calculated to obtain the spring constant value and the damping coefficient are obtained. The experimental results showed that for experiments using the acceleration sensor, the spring constant values k = (11.8 ± 0.2) N m−1. For experiments using a video tracker the spring constant values k = (12.1 ± 0.4) N m−1. Experiments using the acceleration sensor can explain the acceleration trends that change periodically whereas when we use a video tracker it explains the trends in positions that change periodically. But, based on the standard deviation, showing that experiments using acceleration sensors obtain more precise results. We hope that mechanical experiment using smartphone acceleration sensors can be applied in physics laboratories on high schools and colleges, because that is easy, inexpensive, and also the results are more precise.
Comparison of deep learning synthesis of synthetic CTs using clinical MRI inputs
Authors: Massa Haley A , Johnson Jacob M , McMillan Alan B 
Published: October 2020

Abstract
There has been substantial interest in developing techniques for synthesizing CT-like images from MRI inputs, with important applications in simultaneous PET/MR and radiotherapy planning. Deep learning has recently shown great potential for solving this problem. The goal of this research was to investigate the capability of four common clinical MRI sequences (T1-weighted gradient-echo [T1], T2-weighted fat-suppressed fast spin-echo [T2-FatSat], post-contrast T1-weighted gradient-echo [T1-Post], and fast spin-echo T2-weighted fluid-attenuated inversion recovery [CUBE-FLAIR]) as inputs into a deep CT synthesis pipeline. Data were obtained retrospectively in 92 subjects who had undergone an MRI and CT scan on the same day. The patient’s MR and CT scans were registered to one another using affine registration. The deep learning model was a convolutional neural network encoder-decoder with skip connections similar to the U-net architecture and Inception V3 inspired blocks instead of sequential convolution blocks. After training with 150 epochs and a batch size of 6, the model was evaluated using structural similarity index (SSIM), peak SNR (PSNR), mean absolute error (MAE), and dice coefficient. We found that feasible results were attainable for each image type, and no single image type was superior for all analyses. The MAE (in HU) of the resulting synthesized CT in the whole brain was 51.236 ± 4.504 for CUBE-FLAIR, 45.432 ± 8.517 for T1, 44.558 ± 7.478 for T1-Post, and 45.721 ± 8.7767 for T2, showing not only feasible, but also very compelling results on clinical images. Deep learning-based synthesis of CT images from MRI is possible with a wide range of inputs, suggesting that viable images can be created from a wide range of clinical input types.