bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing the efficacy and safety of duloxetine and amitriptyline in the treatment of fibromyalgia: overview of systematic reviews
Authors: de Farias Áurea Dias , Eberle Luciana , Amador Tânia Alves , da Silva Dal Pizzol Tatiane 
Published: July 2020

Abstract
Background
Duloxetine and amitriptyline are antidepressants used in the treatment of fibromyalgia. In published systematic reviews, there is no agreement about which drug is more effective and safer. This study aimed to compare evidence of the efficacy and safety of duloxetine compared with amitriptyline in the treatment of adult patients with fibromyalgia. This work contributes to guiding clinicians on the use of duloxetine or amitriptyline for the treatment of fibromyalgia and provides information for public health decision-makers.

Methods
Overview of systematic reviews of clinical trials comparing duloxetine and amitriptyline in the treatment of fibromyalgia. The reviews were screened in Cochrane, PubMed, EMBASE, and SRDR with no restrictions on language and year of publication, considering that the research was conducted in July 2018 and updated until May 2020. The selection was based on the following criteria: adult patients with a diagnosis of fibromyalgia treated with duloxetine or amitriptyline, comparing the efficacy and safety in pain, fatigue, sleep, and mood disorder symptoms and quality of life, in addition to the acceptability of these antidepressants. The methodological quality and strength of evidence were assessed using the AMSTAR and GRADE instruments.

Results
Eight systematic reviews were selected. Amitriptyline had low evidence for pain, moderate evidence for sleep and fatigue, and high evidence for quality of life. Duloxetine had high quality of evidence in patients with mood disorders. With low evidence, duloxetine has higher acceptability, but is safer in older patients, while amitriptyline is safer for non-elderly individuals.

Conclusion
Both antidepressants are effective in the treatment of fibromyalgia, differing according to the patient’s symptoms and profile.

Registration
PROSPERO: CRD42019116101.
Adolescents’ social needs living with juvenile idiopathic arthritis and their views about digital resources
Authors: Beneitez Imma , Nieto Rubén , Hernández Eulàlia , Boixadós Mercè 
Published: July 2020

AbstractBackgroundJuvenile Idiopathic Arthritis (JIA) and its related symptoms (e.g. pain) have been associated with interference in the daily life of adolescents with JIA including their friendships. There is little research in that sense and in consequence, interventions designed to improve this area. The objectives of this study are 1) to gain knowledge about the needs of adolescents with JIA, particularly focused on their friendships; 2) to explore the potential of the Internet to help them, and 3) to determine what kind of online resource would be the best and what elements it should include.MethodsTo achieve the proposed objectives we designed a qualitative study including two phases: the first one exploratory (semi-structured interviews) and the following, confirmatory (online focus group).Results14 adolescents were interviewed and 7 participated in the focus group. They reported some social challenges related to their illness: feeling different, criticized by peers, or not believed. Additionally, they specified some of the coping strategies they used, such as disclosing to others that they have JIA, using communication skills, maintaining activities with friends, trying to minimize pain, and ignoring negative comments. Adolescents considered an online resource useful and mentioned that they would like to find general information and to have the possibility to interact with others. They considered Instagram and WhatsApp as good platforms to implement the online resource.ConclusionsAccording to their perceptions, adolescents with JIA can benefit from an online resource which delivers information, strategies and facilitates interaction with others.
Guillain-Barré syndrome and SARS-CoV-2
Authors: Lampe Anne , Winschel Alexander , Lang Cornelie , Steiner Thorsten 
Published: July 2020

AbstractSince January 2020, after Chinese health authorities identified a new type of coronavirus (SARS-CoV-2), the virus has spread throughout China and consecutively throughout the whole world. The most common symptoms include fever and respiratory tract symptoms. Nevertheless, some patients show less common symptoms such as gastrointestinal or neurological manifestations. This article presents the case of a 65-years old man who was presumptively infected with SARS-CoV-2 during his ski vacation in Austria in March 2020 and acutely presented with typical symptoms of Guillain-Barré syndrome.
Transcatheter closure of Patent ductus arteriosus in a child with IVC interruption through standard femoral access: a case report
Authors: Naganur Sanjeev H. , Pruthvi C. R. , Bootla Dinakar , Prasad Krishna , Krishna Santosh V. , Barwad Parag 
Published: July 2020

Abstract
Background
Portsmann and co. performed the first PDA device closure in 1967. The technique and the devices used have evolved since then and are the first choice in managing anatomically feasible patent ductus arteriosus (PDA) for the last 20 years. Though catheter-based closure of PDA is generally a simple procedure, there are instances when the interventionist faces challenges, especially in smaller children, with syndromic features and venous anomalies even when defects are small and pulmonary artery pressures are normal. Although the femoral vein is the relatively risk-free standard access, internal jugular vein, femoral artery, and transhepatic IVC can be used to close the PDA in different anomalies.
The rare venous anomaly of infrahepatic interruption of the IVC with azygous continuation poses technical challenges when percutaneous closure of PDA was attempted through the standard femoral access.

Case presentation
We report a rare case of PDA device closure in a syndromic child with a short neck having interrupted IVC via femoral-azygous venous approach.

Conclusion
Knowledge of the IVC course and its anomalies should be known to the operator before the percutaneous closure of PDA. Although other approaches are available, femoral vein approach can be used in case of interrupted IVC for percutaneous closure of PDA.
A clinical study of suicide in patients admitted in psychiatry unit in Assiut University
Authors: Hassan Wageeh A. N. , Noaman Mostafa M. , Khalifa Hossam , Abdelrahman Ahmed A. , Omar Sally M. 
Published: July 2020

AbstractBackgroundThis study was performed for clinical study of suicide including risk factors in psychiatric patients admitted in psychiatric unit of Assiut University Hospital (AUH).ResultsWe found that frequency of suicidal attempts is more in MDD (major depressive disorder), bipolar disorders followed by schizophrenia. And frequency of suicidal attempts in patients with multiple previous attempts before this one was higher in patients with mood disorders (53.8%) than psychotic and substance-induced disorders (32.3%, 13.8% respectively), with statistically significant difference in patients with MDD as well as there was significant treatment outcome on suicidal behavior.ConclusionThe frequency of suicidal attempts is more in MDD (major depressive disorder), bipolar disorders followed by schizophrenia. There was significant severity of suicidal behavior in patients with psychotic disorders in comparison to patients with substance-induced disorder or mood disorders.
The correlation between pre-operative ultrasonographic median nerve evaluation and the operative procedure in CTS
Authors: Allam Ahmad Fouad Abdelbaki , Sadek Ahmed Fathy , AbuSamra Manal Fayez , Ismail Ahmed Hamed , Allam Mohammad Fouad Abdel Baki 
Published: July 2020

Abstract
Background
Ultrasonography is a convenient non-invasive diagnostic tool with wide availability and cost effectiveness. Musculoskeletal ultrasonography is a growing field used for diagnosis of many musculoskeletal disorders; carpal tunnel syndrome (CTS) could be one of these disorders. The purpose of this study was to assess the impact of median nerve ultrasonography in carpal tunnel syndrome on surgical management, and its added value in operative techniques selection, and in tailoring the surgical steps. Thirty patients with CTS and thirty normal subjects underwent superficial ultrasonography. The cross-sectional area at different levels and flattening ratios were measured on both groups. The patients who had failed conservative treatment had surgical carpal tunnel release.

Results
There was significant positive correlation between the need for external neurolysis with increased flattening ratio with cutoff values > 4, and between the need for approach extension with increased cross-sectional area difference between pisiform level and pronator quadratus level with cutoff values of cross-sectional area difference > 7.

Conclusions
Ultrasonographic measurements of median nerve in CTS could be helpful in selection and modification of operative procedure including the surgical approach and need for neurolysis.
A longitudinal implementation evaluation of a physical activity program for cancer survivors: LIVESTRONG® at the YMCA
Authors: Faro Jamie M. , Arem Hannah , Heston Ann-Hilary , Hohman Katherine H. , Hodge Heather , Wang Bo , Lemon Stephenie C. , Houston Thomas K. , Sadasivam Rajani S. 
Published: July 2020

Abstract
Purpose
Increased physical activity (PA) levels in cancer survivors are associated with decreased risk of recurrence and mortality as well as additional positive health outcomes. PA interventions have shown to be efficacious, though many lack translation to and sustainability in community settings. We used dimensions of the RE-AIM framework to evaluate LIVESTRONG® at the YMCA, a nation-wide community-based PA program for cancer survivors delivered at Ys.

Methods
This was a longitudinal study design using national LIVESTRONG at the YMCA data compiled between 2010 and 2018. Data is from all YMCAs who deliver LIVESTRONG at the YMCA, submitted by Program Directors to the YMCA-USA. We assessed reach (number of participants), adoption (associations offering the program), implementation (conducting 3 fidelity checks), and organizational level maintenance (associations recently offering program). We also examined relationships between organizational characteristics (years of program existence and association area household income) and program implementation factors with member conversion rates.

Results
As of 2018, LIVESTRONG at the YMCA has reached 62,044 survivors and 245 of the 840 (29.2%) of Y associations have adopted the program. Among the adopters, 91% were aware of fidelity checks; implementation of observational (62.3%), goal setting (49.9%), and functional (64.6%) checklists varied. Most (95.1%) adopters reported offering ≥ 1 LIVESTRONG session per year (organizational-level maintenance) and a facility-level mean membership conversion percentage of 46.9 ± 31.2%. Fewer years implementing the program and higher association area household income were significantly associated with a greater membership conversion rate vs their comparison. In a multiple regression model controlling for organizational characteristics, conducting the fidelity checks independently (observational, β = 8.41; goal-setting, β = 9.70; and functional, β = 9.61) and collectively (β = 10.82; 95% CI 5.90–16.80) was positively associated with higher membership conversion rates.

Conclusions
LIVESTRONG at the YMCA, in its early years, has shown promise for high reach, while adoption at more associations could be facilitated. Implementing fidelity checks along with organizational characteristics were associated with membership conversion rate. Identification of association-level strategies to increase reach, adoption, implementation, and maintenance may increase the impact of this community-based PA program.
Telemedicine During the COVID-19 Pandemic: Impact on Care for Rare Cancers
Authors: Smrke Alannah , Younger Eugenie , Wilson Roger , Husson Olga , Farag Sheima , Merry Eve , Macklin-Doherty Aislinn , Cojocaru Elena , Arthur Amani , Benson Charlotte , Miah Aisha B. , Zaidi Shane , Gennatas Spyridon , Jones Robin L. 
Published: July 2020

PURPOSE Many patients with cancer, often those with rare cancers such as sarcomas, travel long distances to access expert care. The COVID-19 pandemic necessitated widespread changes in delivery of cancer care, including rapid adoption of telemedicine-based care. We aimed to evaluate the impact of telemedicine on patients, clinicians, and care delivery at the Royal Marsden Hospital (RMH) Sarcoma Unit during the pandemic. METHODS Data were extracted from patient records for all planned outpatient appointments at the RMH Sarcoma Unit from March 23 to April 24, 2020. Patients and clinicians completed separate questionnaires to understand their experiences. RESULTS Of 379 planned face-to-face appointments, 283 (75%) were converted to telemedicine. Face-to-face appointments remained for patients who needed urgent start of therapy or performance status assessment. Patients lived on average > 1.5 hours from RMH. Patient satisfaction (n = 108) with telemedicine was high (mean, 9/10), and only 48% (n = 52/108) would not want to hear bad news using telemedicine. Clinicians found telemedicine efficient, with no associated increased workload, compared with face-to-face appointments. Clinicians indicated lack of physical examination did not often affect care provision when using telemedicine. Most clinicians (n = 17; 94%) believed telemedicine use was practice changing; congruently, 80% (n = 86/108) of patients desired some telemedicine as part of their future care, citing reduced cost and travel time. CONCLUSION Telemedicine can revolutionize delivery of cancer care, particularly for patients with rare cancers who often live far away from expert centers. Our study demonstrates important patient and clinician benefits; assessment of longer-term impact on patient outcomes and health care systems is needed.
Primary Care Provider Involvement in Thyroid Cancer Survivorship Care
Authors: Radhakrishnan Archana , Reyes-Gastelum David , Gay Brittany , Hawley Sarah T , Hamilton Ann S , Ward Kevin C , Wallner Lauren P , Haymart Megan R 
Published: July 2020

AbstractContextWhile prior research has examined how primary care providers (PCPs) can care for breast and colon cancer survivors, little is known about their role in thyroid cancer survivorship.ObjectiveTo understand PCP involvement and confidence in thyroid cancer survivorship care.Design/Setting/ParticipantsWe surveyed PCPs identified by thyroid cancer patients from the Georgia and LA SEER registries (n = 162, response rate 56%). PCPs reported their involvement in long-term surveillance and confidence in handling survivorship care (role of random thyroglobulin levels and neck ultrasound, and when to end long-term surveillance and refer back to the specialist). We examined: 1) PCP-reported factors associated with involvement using multivariable analyses; and 2) bivariate associations between involvement and confidence in handling survivorship care.Main Outcome MeasuresPCP involvement (involved vs not involved) and confidence (high vs low).ResultsMany PCPs (76%) reported being involved in long-term surveillance. Involvement was greater among PCPs who noted clinical guidelines as the most influential source in guiding treatment (OR 4.29; 95% CI, 1.56-11.82). PCPs reporting high confidence in handling survivorship varied by aspects of care: refer patient to specialist (39%), role of neck ultrasound (36%) and random thyroglobulin levels (27%), and end long-term surveillance (14%). PCPs reporting involvement were more likely to report high confidence in discussing the role of random thyroglobulin levels (33.3% vs 7.9% not involved; P &lt; 0.01).ConclusionsWhile PCPs reported being involved in long-term surveillance, gaps remain in their confidence in handling survivorship care. Thyroid cancer survivorship guidelines that delineate PCP roles present one opportunity to increase confidence about their participation.
Risk Factors for Intraoperative Hypoglycemia in Children: A Multicenter Retrospective Cohort Study
Authors: Riegger Lori Q. , Leis Aleda M. , Golmirzaie Kristine H. , Malviya Shobha 
Published: July 2020

BACKGROUND:
Intraoperative hypoglycemia can result in devastating neurologic injury if not promptly diagnosed and treated. Few studies have defined risk factors for intraoperative hypoglycemia. The authors sought to characterize children with intraoperative hypoglycemia and determine independent risk factors in a multicenter cohort.

METHODS:
This retrospective multicenter study included all patients <18 years undergoing an anesthetic from January 1, 2012, to December 31, 2016, at 12 institutions participating in the Multicenter Perioperative Outcomes Group (MPOG). The primary outcome was blood glucose <60 mg/dL (3.3 mmol/L). Data collected included patient characteristics, comorbidities, and intraoperative factors. A multivariable logistic regression model was used to identify independent predictors of intraoperative hypoglycemia.

RESULTS:
Blood glucose was measured in 26,142 of 394,231 (6.6%) cases. Of these, 1017 (3.9%) had a glucose <60 mg/dL (3.3 mmol/L). Independent predictors for intraoperative hypoglycemia identified were age <30 days (estimated adjusted odds ratio [AOR] vs ≥5 years 4.2; 95% confidence interval [CI], 3.4–5.3), age 30 days to <5 years (estimated AOR vs ≥5 years 2.7; 95% CI, 2.3–3.2), weight for age <5th percentile (estimated AOR, 1.6; 95% CI, 1.4–1.9), American Society of Anesthesiologists (ASA) status ≥III (estimated AOR, 1.3; 95% CI, 1.1–1.6), presence of a gastric or jejunal tube (estimated AOR, 1.3; 95% CI, 1.1–1.6), poor feeding (estimated AOR, 1.5; 95% CI, 1.2–1.7), and abdominal surgery (estimated AOR, 1.4; 95% CI, 1.1–1.7). Eighty percent of hypoglycemia occurred in children <5 years of age and in children <20 kg.

CONCLUSIONS:
Young age, weight for age <5th percentile, ASA status ≥III, having a gastric or jejunal tube, poor feeding, and abdominal surgery were risk factors for intraoperative hypoglycemia in children. Monitoring of blood glucose is recommended in these subsets of children.
Responses to transient receptor potential (TRP) channel agonists inChlamydomonas reinhardtii
Authors: Wada Mamoru , Kaizuka Itaru , Yoshimura Kenjiro 
Published: July 2020

ABSTRACTPungent substances, such as capsaicin and gingerol, activate the transient receptor potential (TRP)-V1 channel and affect the feeding behaviors of animals. To gain insight into how living organisms have acquired a sense for pungent substances, we explored the response to TRP agonists in a protist, Chlamydomonas reinhardtii. When capsaicin or gingerol was applied to wild-type cells, they became immotile, with flagella detaching from the cell body. The degree of deflagellation was nearly halved in a mutant defective in the TRP channel ADF1. Deflagellation in the adf1 mutant was inhibited further by Ruthenium Red, indicating ADF1 and another TRP channel are involved in the deflagellation response. The response to capsaicin and gingerol was not inhibited by TRPV1-specific blockers such as 4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide (BCTC) and capsazepine. When capsaicin or gingerol was applied to wild-type cells in the presence of Ruthenium Red, a large proportion lost motility while flagella remained attached, suggesting that flagella stop contributing to motility, at least in part, through a TRP-channel-independent pathway. These results indicate that pungent compounds such as capsaicin and gingerol induce loss of flagellar motility and flagellar detachment in C. reinhardtii cells.
Farmers’ knowledge, attitudes and practices towards management of cassava pests and diseases in forest transition and Guinea savannah agro-ecological zones of Ghana
Authors: Nsiah Frimpong Benedicta , Oppong Allen , Prempeh Ruth , Appiah-Kubi Zipporah , Abrokwah Linda A. , B. Mochiah Moses , N. Lamptey Joseph , Manu-Aduening Joseph , Pita Justin 
Published: July 2020

Background: Cassava is a major staple root crop in Ghana, which serves as a food security and an income generating crop for farming families. In spite of its importance, the crop is plagued with biotic factors such as pests and diseases, resulting in yield and income reductions. Methods: Farmers’ knowledge, attitudes and practices towards cassava pest and disease management were investigated. A mixed method research questionnaire was used to collect both qualitative and quantitative data from 94 cassava farm households across two major cassava growing agro-ecologies. Results: Using descriptive statistics, parametric and non-parametric analysis, our study revealed that farmers’ knowledge on cassava pests was high but low for diseases. Whiteflies (Bemisia tabaci Gennadius), grasshoppers (Zonocerus variegatus), aphids (Aphis gossypii Glover), mealybugs (Phenacoccus manihoti), termites (Isoptera), and grasscutters (Thryonomys swinderianus) were perceived as the most common damaging pests. Farmers’ descriptions showed that disease pathogens attacked foliar tissues, stem and root tissues and caused leaf dropping and die back. Cassava mosaic disease and root rot were the most common diseases; however, disease descriptions suggested the incidence of viral, bacterial and fungal diseases. Some of the farmers observed mixed infections on their farms. The results also showed that only 25.5% cultivated improved varieties. Management actions applied included field sanitation practices and pesticide application. The effectiveness level of the control actions was rated moderately effective. Conclusions: The analysis showed heterogeneity in personal and farm level characteristics of respondents across the two agro-ecologies, but agro-ecologies were independent of the management practices employed. There is a need to improve farmers’ access to improved disease-free planting materials through efficient dissemination pathways and increase farmers’ knowledge on cassava pests, diseases and integrated management through publfic awareness creation and capacity building by extension agents and research institutions. Continued government investment is needed to achieve sustainable outcomes.
Model of a variable system of professional development of police officers-employees of temporary detention Centers for juvenile offenders (Center)
Authors: Erofeeva Mariya , Mironenkova Ol'ga 
Published: July 2020

The process of professional training of police officers of working with teenagers is built within the framework of personal-activity and subjective approaches, that is, the choice of forms, methods and means of training is carried out taking into account their ability to achieve the expected success in the form of personal and professional development.
The article offers a structural and functional model of a variable system of professional development of police officers who perform their official and professional duties in the Central police service CENTER.
The model is a system that includes four blocks: a diagnostic-orientation block, a content-target block, a process-technology block, and a process-technology block.
The content block is characterized by the following types of individual educational trajectory of continuing professional education: adaptive trajectory, correcting trajectory, activating, acmeological type.
In accordance with the theoretical analysis and practical experience of service in temporary detention centers for juvenile offenders, four main categories of employees are identified.
The technology of training police officers to work with teenagers using interactive methods is presented.