bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modulation of androgen receptor DNA binding activity through direct interaction with the ETS transcription factor ERG
Authors: Wasmuth Elizabeth V. , Hoover Elizabeth A. , Antar Albert , Klinge Sebastian , Chen Yu , Sawyers Charles L. 
Published: March 2020

Significance
Progress in studying the androgen receptor (AR), the primary drug target in prostate cancer, has been hampered by challenges in expressing and purifying active multidomain AR for use in cell-free biochemical reconstitution assays. Here we successfully express full-length and truncated AR variants and demonstrate that the oncogenic ETS protein ERG, responsible for half of all prostate cancers, enhances the ability of AR to bind DNA through direct interaction with AR. In addition to providing a biochemical system to evaluate AR activity on different DNA templates, our findings provide insight into why ERG-positive prostate cancers have an expanded AR cistrome.
The interplay of prior experience and actual situational context in intercultural first encounters
Authors: Kecskes Istvan 
Published: March 2020

AbstractThe study aims to investigate how prior experience of interlocutors interacts with actual situational context in intercultural interactions when the latter is represented by a well-known frame: getting acquainted with others. It attempts to demonstrate how the cultural frame of the target language is broken up and substituted with an emergent frame that is co-constructed from elements from prior experience with the target language, the first language and the actual situational experience.Getting acquainted with others is a closed social situation, a cultural frame in which interlocutors usually have to follow a behavior pattern dictated by the requirements of the socio-cultural background in a given speech community. There is a ‘skeleton’ of these ‘getting to know you’ procedures that can be considered universal but is substantiated differently in every language. In each conversation in any language, ‘flesh’ is added to the ‘skeleton’ in a dynamic and co-constructed manner. However, there is a difference between how this happens in L1 and in intercultural interactions. While in L1 the ‘flesh’ on the skeleton is predetermined to a significant extent by requirements of core common ground in the given language, in intercultural encounters this ‘flesh building’ process in the target language (in this case English) is not set but is co-constructed by the interlocutors as emergent common ground relying on their prior experience with their own L1 culture, limited experience with the target culture and the assessment of the actual situational context. In this study the co-construction process, i.e. emergent common ground will be analyzed by examining the use of formulaic language and freely generated language in several discourse segments.
Guidelines for designing the antithetic feedback motif
Authors: Baetica Ania-Ariadna , Leong Yoke Peng , Murray Richard M 
Published: March 2020

Abstract
Integral feedback control is commonly used in mechanical and electrical systems to achieve zero steady-state error following an external disturbance. Equivalently, in biological systems, a property known as robust perfect adaptation guarantees robustness to environmental perturbations and return to the pre-disturbance state. Previously, Briat et al proposed a biomolecular design for integral feedback control (robust perfect adaptation) called the antithetic feedback motif. The antithetic feedback controller uses the sequestration binding reaction of two biochemical species to record the integral of the error between the current and the desired output of the network it controls. The antithetic feedback motif has been successfully built using synthetic components in vivo in Escherichia coli and Saccharomyces cerevisiae cells. However, these previous synthetic implementations of antithetic feedback have not produced perfect integral feedback control due to the degradation and dilution of the two controller species. Furthermore, previous theoretical results have cautioned that integral control can only be achieved under stability conditions that not all antithetic feedback motifs necessarily fulfill. In this paper, we study how to design antithetic feedback motifs that simultaneously achieve good stability and small steady-state error properties, even as the controller species are degraded and diluted. We provide simple tuning guidelines to achieve flexible and practical synthetic biological implementations of antithetic feedback control. We use several tools and metrics from control theory to design antithetic feedback networks, paving the path for the systematic design of synthetic biological controllers.
Analysis of Mathematical Critical Thinking Skill of Junior High School Students on the Two-Variable Linear Equation System
Authors: Utami P , Bharata H 
Published: March 2020

Abstract
This study aimed to analyze the students’ mathematical critical thinking skill on the two-variable linear equations system. This research is a descriptive study with a qualitative approach. The subject of this study was 32 students of grade 8 in Junior High School Satu Atap 3, Jati Agung, Lampung. The data collection techniques used Critical Thinking Instrument with two problem descriptions. Furthermore, the data collected was analyzed based on indicators of critical thinking skill set by the researchers which included interpretation, analysis, evaluation, and inference. Based on the data analysis, the average of critical thinking skill of students is 52.15%, in the low category. The percentage of interpretation aspects is 53.13%, in the low category, the analysis aspect is 52.73% in the low category, the evaluation aspect is 54.30%, in the low category, and the inference aspect is 48.44%, in the low category. The results of this study indicated that the students’ critical thinking skills are still low so it is expected that by knowing these conditions the teachers and researchers are able to choose, design, and develop the learning that facilitates the students to practice critical thinking.
The Effectiveness of STEM Learning: Scientific Attitudes and Students’ Conceptual Understanding
Authors: Thahir A , Anwar C , Saregar A , Choiriah L , Susanti F , Pricilia A 
Published: March 2020

Abstract
This study aims to see the effectiveness of the learning approaches toward scientific attitudes and conceptual understanding. The research method used was quasi-experimental research with a pretest-posttest control design. The scientific attitude data was obtained using a questionnaire while the conceptual understanding data was obtained through a test instrument in the form of a description item. The results of the study are (1) there are differences in scientific attitudes and students’ conceptual understanding taught using STEM learning approach and conventional learning, (2) there is a difference in conceptual understanding between students who were taught using the STEM learning approach and conventional learning, and (3) there are significant differences in scientific attitudes between students who were taught using the STEM learning approach and students who were taught using conventional learning.
The Development of Biology Module Based on Local Wisdom of West Lampung: Study of Ecosystem Material
Authors: Haka N B , Anggoro B S , Hamid A , Novitasari A , Handoko A , Puspita L 
Published: March 2020

Abstract
Education has a mission to develop the potential of students, develop their personality, and be able to foster a sense of responsibility. For this reason, teaching materials are needed. Module teaching materials based on local wisdom on ecosystem materials are not yet available as Teaching materials used by schools. For this reason, it was necessary to develop module teaching materials based on local wisdom in supporting the achievement of competencies and learning objectives. This study aimed to determine the development, feasibility and response of students and educators towards the Biology module based on local wisdom in West Lampung. This study used Research & Development (R&D) method with Borg & Gall procedure. Data collection techniques were using expert questionnaires (teaching modules, materials, languages), response questionnaires (students and educators), and documentation. Riduwan modified Likert scale research data analysis techniques were used. The results showed the module was suitable for using in the learning process based on the module quality assessment by experts (teaching modules, material, and language) with overall criteria very feasible. Biology educator’s response was very positive towards the teaching module products. It could be concluded that the module is suitable for use in the biology learning process.
Gamal Leaves (Gliricidia sepium) as Hydroponic Nutrition for Lettuce (Lactucasativa L.)
Authors: Indarto  , Qoniah U , Ulmillah A , Fatimatuzzahra  , Maretta G , Sugiharta I 
Published: March 2020

Abstract
Cultivating with a hydroponic system is an alternative with increasingly limited agricultural land. Gamal leaves contain nutrients that are suitable to be used as hydroponic nutrients for lettuce (Lactuca sativa L.). This article will explain the effect of Gamal leaves nutrition on the growth and productivity of lettuce using the hydroponic method. The method used in this study was a Completely Randomized Design (CRD) consisting of 5 treatments namely P1 = (negative control) only water, P2 = 20% Gamal leaf nutrition, P3 = 30% Gamal leaf nutrition, P4 = leaf nutrition 40% Gamal and P5 = (positive control) AB-Mix nutrition. The parameters observed consisted of plant height, number of leaves, leaf width and gross weight. Analysis with One Way ANOVA assisted by SPSS 17 and LSD advanced test. The results on the parameters observed and analyzed carried out had a real effect on all parameters. Gamal leaf nutrition treatment on plant height P4 and P2 were not significantly different from P2, the number of leaves and leaf width of P2, P3 and P4 were not significantly different, whereas the wet weight P4 had the highest value which is significantly different from other treatments.
How Is the Students’ Concept Mastery in Terms of Gender Differences? The Effectiveness of Probing Prompting Learning Model
Authors: Amalia Ricadesta , Trisnaningsih  , Anwar C , Thahir A , Lutfiana N , Susilowati N E , Wekke I S , Saregar A 
Published: March 2020

AbstractThe relationship between gender and educational outcomes is still very interesting to talk about. This study aims to test the effectiveness of the probing prompting learning model on the physics concept mastery, the effect of gender on the physics concept mastery and examine the interaction between the application of the probing prompting learning model and discovery learning in terms of gender on the students’ physics concept mastery. The research method used is quasi-experiment with a post-test only control group design. The research sample consisted of two classes chosen by purposive sampling technique; class VIII A as the experimental class and class VIII B as the control class. Data collection techniques used were test to obtain the data of concept mastery. The hypothetical test used was two-way ANOVA. The conclusions from the results of this study are: (1) The probing prompting learning model is more effective than the discovery learning model on students’ physics concept mastery, (2) gender affects the students’ physics concept mastery, and (3) there is no interaction between the application of the probing prompting learning model and discovery learning in terms of gender toward the students’ physics concept mastery.
Reconstruction of Teaching Materials with Socio-Scientific Issues Context on Source of Energy Content
Authors: Saefullah A , Guntara Y , Nulhakim L 
Published: March 2020

Abstract
One innovation that can be done to improve the quality of science learning is through the development of teaching materials. In this study teaching material was developed through a reconstruction process, where regard to educational goals, carefully described, and related to the context in real life. One of the science contents that is very close to the context in real life is a source of energy. Source of energy content can be used in science learning as a controversial Socio-Scientific Issues (SSI). This study used a modified R&D in two mains steps, research and initial information collection, as well as planning and development of products that adopt model of educational reconstruction (MER). Teaching material with SSI context on source of energy content that had been developed has several characteristics including, designed based on SSI learning, each description in theme is packaged by context, consisting of a cover page, introduction structure, end section, and additional reading lists. The teaching materials are validated and given an evaluation by experts to determine the feasibility of the teaching materials. In addition, students collected responses to determine the level of understanding and expectations of students towards teaching material that had been produced.
Community Participation in Flood Disaster Mitigation Oriented on The Preparedness: A Literature Review
Authors: Nugraheni I L , Suyatna A 
Published: March 2020

Abstract
The purpose of this paper is to examine community participation in mitigating flood preparedness. The method used in the form of meta-analysis from the literature study of various journal articles in 2011-2019 with the topic of flood disaster mitigation in Indonesia includes Sumatra, Java, Sulawesi, Kalimantan, taken from the international journal Disaster risk reduction, Sumatra Journal of disaster, geography and geography education Jamba: Journal of disaster risk studies, nature science, and from international seminars. The lack of articles in Indonesia that discusses public participation in English language flooding disasters such as articles from other countries, causes this research has never been done. The review results show that of the 9 articles used, it turns out that community participation in dealing with floods in several regions in Indonesia is included in the active category. Forms of participation include participation in the form of money, labor contributions, inter-community education, supervision of infrastructure development and the addition of green open space.
The Making of E-Portfolios for Performance Assessment in Chemical Practicum
Authors: Hakim R Ismail , Irwansyah F S , Farida Ida 
Published: March 2020

Abstract
This research aims to create a media that can facilitate the assessment of chemical practicum following the development of information technology. Through the Design-Based Research method, an e-portfolio has been made for performance evaluation on chemical practicum that can assess the work of student practicum in the form of documents, photos, and videos online.E-portfolios can be used to assess aspects of planning, implementation, and reporting on digital-based chemical labs. The validation results show that the product is declared valid by the acquisition of an average value of 0.85. The results of a limited trial conducted on chemistry education students indicate that the product is declared suitable for use with an average percentage value of 86.87%.
The Scientific Argumentation Profile of Earthquake Mitigation of Non-Science Undergraduate Student in Universitas Negeri Surabaya
Authors: Deta Utama Alan , Fadillah Rizki Nur , Ria Agustina Putri Zulaiha , Prakoso Irvan , Nurlailiyah Alfi , Saregar Antomi , Misbah  , Lestari Nurita Apridiana 
Published: March 2020

Abstract
Arguments are one of the important purposes in the modern era of learning because it is the basic step to promote student’s critical thinking process and science literature. This research aims to describe and analyse scientific argumentation profile of earthquake of non-science undergraduate student in Universitas Negeri Surabaya. This research uses a qualitative descriptive with the subject of research is 37 first-year non-science students from Universitas Negeri Surabaya. The subject asked to choose the right answer and write their reasons or arguments that support their answer. The results showed that the subject’s ability in providing scientific argument is at the level of providing claims with the support of well warrant.
Identification of Students’ Metacognitive Levels in Physics Learning Viewed from the Problem-Solving Ability
Authors: Yuberti  , Kartika I , Viyanti  , Wulandari H , Anillah  
Published: March 2020

Abstract
This study aimed to look at the level of physics problem-solving ability achieved by students and identify the level of metacognition based on the ability to solve physics problems at each level. The research method used was a mixed method with a sequential explanatory strategy. The populations in this study were all eleventh-grade science students of Kebumen Islamic High School, Tanggamus District. The sampling technique used was a balanced sample with a participant selection model. The instruments used in this study were the physics tests, interviews, and documentation. The data analysis process included two stages of analysis, namely quantitative data analysis and qualitative data analysis. The results of this study indicated that 12.12% of students belong to the high problem-solving group, 66.67% of students belong to the moderate problem-solving group, and 21.21% of students belong to the low problem-solving group. The high problem-solving group had a high level of metacognition, namely Semi-reflective use with a percentage of 10% and Strategic use with a percentage of 10%. The moderate problem-solving group had Semi-strategic use level with a percentage of 40% and Aware use with a percentage of 20%. The low problem-solving group had the lowest metacognition level, namely Tacit use with a percentage of 20% of the total sample taken. so, the levels of metacognition ability of students in learning physics identified in this study were: tacit use, aware use, semi strategic use, strategic use, and semi-reflective use.
Improving Students’ Science Process Skills and Critical Thinking Skills in Physics Learning through FERA Learning Model with SAVIR Approach
Authors: Diani Rahma , Latifah Sri , Jamaluddin Wan , Pramesti Ardya , Susilowati Nur Endah , Diansah Irani 
Published: March 2020

Abstract
This study aimed to determine the effectiveness of FERA learning model (Focus, Explore, Reflect and Apply) with SAVIR approach in improving students’ science process skills and critical thinking skills in physics learning. The method used in this research was Quasi-Experiment with non-equivalent control group design. The subject of this research was students in one of the senior high schools in Lampung District. MANOVA test (Multivariate of Variance) in SPSS 20 was used as a hypothesis test. The analysis result showed that there were differences in science process skills and critical thinking skills between the experimental class and the control class. The effectiveness of FERA learning model with SAVIR approach in improving students’ science process skills and critical thinking skills in physics learning was tested by Effect Size test. The results showed that FERA learning model with SAVIR approach was more effective in improving students’ science process skills and critical thinking skills than using discovery learning model.
Remote Control Caras Physics Teaching Aids by Utilizing Recycled Wastes
Authors: Dermawan Oki , Ayu Sovia Mas , Junaidah  , Meisuri  , Defriyanto  , Indriyani Rosa 
Published: March 2020

Abstract
This study aimed to determine the feasibility of a simple remote control car by utilizing recycled waste and to know the responses of students regarding the developed remote control car. This study used a research and development (R&D) method proposed by Borg & Gall adapted from Sugiyono’s development model. The data of this study were obtained from the teacher’s questionnaire and students’ responses, material expert validation, and media expert validation. The type of data generated is qualitative data that was analyzed based on the assessment criteria to determine the product’s quality. The score obtained from the material expert is 80.59%, the score obtained from the media expert is 92.92%, the score from the teachers of three schools is 88.33%, and the score from the students in all schools is 82.50%. Based on the assessment of the material experts, the media experts, and the teachers, it can be concluded that the remote control car as physics teaching aids using recycled wastes suitable to be used as teaching aids.
Identifying K-10 Students’ Learning Difficulties on Learning Kepler’s Law using Worksheet: Is It Worth?
Authors: Setyadin A H , Suryana T G S , Utari S , Efendi R , Liliawati W , Utama J A 
Published: March 2020

Abstract
This study set out to identify K-10 students’ learning difficult when they learn about Kepler’s Law. The research method utilized in this study was the single-intrinsic case study. The subject of this study was 19 students of one of a private school in Cianjur, Indonesia that consist of 12 females and 7 males from people with a background were mostly merchant. Students’ worksheet was used to identify students’ learning obstacles. Through the qualitative analysis of student answers to student worksheets, it can be found that students’ learning difficulties when learning Kepler Laws in the form: 1) understand the physical meaning of First Kepler’s law, 2) identify and discover the relationship of physical quantities that work planets when interacting with the sun, 3) perform mathematical operations to derivate the Kepler’s third law equation and apply it in some cases. Through this analysis, we can identify K-10 grade students’ learning difficulties when learning Kepler’s Laws.
Developing an Android-Based Test on Colligative Properties of Solution
Authors: Sari S , Nuralam R , Subarkah C Z 
Published: March 2020

Abstract
Android-based tests in chemistry are still limited and few in development. This research has been carried out to describe the result of developing an Android-based test on the colligative properties of the solution. The method used in this research was descriptive qualitative. The product/application was created using the Android Studio application (in the.apk format) and can be used on smartphones. Moreover, its details are described, including every visual appearance. The application is interesting, easy to use, can be accessed offline and visualizes animated videos so that it can be used to measure student’s ability to explain the colligative properties.
Design of Computer-Based Testing for Higher-order Thinking Skills on Static Fluid Material
Authors: Pratiwi Diah Eka , Suyatna Agus , Viyanti V 
Published: March 2020

Abstract
The purpose of this study is to develop a Computer Based Test (CBT) design model that is suitable for stimulating students’ higher-order thinking skills (HOTS) on static fluid material. The development of CBT-HOTS is used as a practice (drill) which is expected to be able to familiarize students in working on computer-based questions. The design of this study is guided by the ADDIE instructional development model with 5 stages of development, namely: the analysis phase, the initial product design stage, the development stage, the product implementation stage, and the product evaluation stage (evaluation). This article only reported up to the design analysis and design stages. Data collection used was a questionnaire collected from 12 high school physics teachers in Lampung Province. The data analysis used was descriptive qualitative analysis. The results of this study were the design of the CBT model that is suitable for stimulating students’ HOTS according to the needs in the field. The designs that were developed include the design of the illustration problems, the design of the quiz settings, the design of the questioning settings, and the design of the stimulus for several types of questions namely fill in the blank, matching, and sequence.