bluuebunny/crossref_metadata_2025_split huggingface dataset:
Texture indices of 4'-[methyl-11C]-thiothymidine uptakepredict p16 status in patients with newly diagnosed oropharyngealsquamous cell carcinoma: Comparison with 18F-FDG uptake
Authors: Ihara Ayumi , Norikane Takashi , Mitamura Katsuya , Yamamoto Yuka , Fujimoto Kengo , Takami Yasukage , Ibuki Emi , Kudomi Nobuyuki , Hoshikawa Hiroshi , Toyohara Jun , Nishiyama Yoshihiro 
Published: August 2020

Abstract
Background: In oropharyngeal squamous cell carcinoma (OPSCC), human papillomavirus (HPV)/p16 status is important as a prognostic biomarker. Purpose: We evaluated the relationship between 4¢-[methyl-11C]thiothymidine (11C-4DST) and 18F-FDG PET texture indices and p16 status in patients with newly diagnosed OPSCC. Methods: We retrospectively reviewed the collected data of 256 consecutive, previously untreated patients with primary head and neck tumors enrolled between November 2011 and October 2019. Complete data on both 11C-4DST and 18F-FDG PET/CT studies before therapy, patients with OPSCC, and p16 status were available for 34 patients. Six of them were excluded because they did not exhibit sufficient 11C-4DST and/or 18F-FDG tumor uptake to perform textural analysis. Finally, 28 patients with newly diagnosed OPSCC were investigated. The maximum standardized uptake value (SUVmax) and 6 texture indices (homogeneity, entropy, short-run emphasis, long-run emphasis, low-gray-level-zone emphasis, and high-gray-level-zone emphasis) were derived from PET images. The presence of p16 expression in tumor specimens was examined by immunohistochemistry and compared with the PET parameters. Results: Using 11C-4DST, the expression of p16 was associated with a higher homogeneity (P = 0.012), lower short-run emphasis (P = 0.005), higher long-run emphasis (P = 0.009), and lower high-gray-level-zone emphasis (P = 0.042) values. There was no significant difference between 18F-FDG PET parameters and p16 status. Conclusion: Texture indices of the primary tumor on 11C-4DST PET, but not 18F-FDG PET, may be of value in predicting the condition’s p16 status in patients with newly diagnosed OPSCC.
Impulsive noise suppressing method in power line communication system using sparse iterative covariance estimation
Authors: Wang Yong , Li Youming , Qi Qinke , Yue Yin , Hu Wenfei , Tang Xiaobo 
Published: August 2020

Abstract
Power line communication is severely affected by impulsive noise, especially asynchronous impulsive noise with high power spectral density and short duration. This paper presents an asynchronous impulsive noise suppression method in power line communication system. Based on the component of the asynchronous impulsive noise and the background noise extracted from the received signal by using a null subcarrier matrix, a sparse iterative covariance estimation method is proposed. A optimization problem for estimating impulsive noise power is formed based on a minimum covariance matrix fitting criterion, and the impulsive noise power is then obtained by an iterative algorithm. After that, the impulsive noise is estimated by using the linear minimum mean square estimate method and subtracted from the received signal. Finally, simulation results show that the proposed method can achieve better performance in terms of bit error rate, and has lower computational complexity.
Adaptive transmission mode switching in downlink MISO-NOMA systems: sum rate maximization and the achievable rate region
Authors: Zhao Zhixin , Wang Dong , Zhang Hongwei , Sang Haitao 
Published: August 2020

Abstract
In this paper, the design of adaptive transmission mode switching (TMS) to maximize the sum rate for the downlink multiple-input-single-output based non-orthogonal multiple access (MISO-NOMA) systems is investigated. Firstly, the colsed-form expressions of the boundary of achievable rate region of two candidate transmission mode, i.e., NOMA-based maximum ratio transmission (NOMA-MRT) and minimum mean square error beamforming (MMSE-BF), are obtained. By obtaining the outer boundary of the union of the achievable rate regions of the two transmission mode, an adaptive switching method is developed to achieve a larger rate region. Secondly, based on the idea that the solution to the problem of weighted sum rate (WSR) optimization must be on the boundary of achievable rate region, the optimal solutions to the problem of WSR optimization for NOMA-MRT and MMSE-BF are obtained, respectively. Subsequently, by exploiting the optimal solutions aforementioned for two transmission modes and the high efficiency of TMS, a low-complexity Joint User pairing and Power Allocation algorithm (JUPA) is proposed to further improve sum-rate performance for the multi-user case. Compared with the Exhaustive Search based user Pairing and Power Allocation algorithm (ES-PPA), the proposed JUPA can enjoy a much lower computation complexity and only suffer a slight sum-rate performance loss, whereas outperforms other traditional schemes. Finally, numerical results are provided to validate the analyses and the proposed algorithms.
Construction and Analysis for Dysregulated lncRNAs and mRNAs in Lipopolysaccharide-Induced Porcine Peripheral Blood Mononuclear Cells
Authors: Zhang Jing , Xu Xin , Chen Hongbo , Kang Ping , Zhu Huiling , Ren Hongyan , Liu Yulan 
Published: August 2020

Abstract
Background: Lipopolysaccharide (LPS) in the outer membrane of Gram-negative bacteria induces an intense inflammatory response in pigs. Long noncoding RNAs (lncRNAs) are emerging as key regulators in inflammation and immunity. However, their functions and profiles in LPS-induced inflammation in pigs are largely unknown. In this study, we profiled global lncRNA and mRNA expression changes in porcine peripheral blood mononuclear cells (PBMCs) treated with lipopolysaccharide (LPS) using lncRNA-seq technique. Result: Totally 43 differentially expressed (DE) lncRNAs and 1082 DE mRNAs were identified in the porcine PBMCs after LPS stimulation. Functional enrichment analysis on DE mRNAs indicated that these genes were involved in inflammation-related signaling pathways, including cytokine-cytokine receptor interaction, TNF, NF-κB, Jak-STAT and TLR signaling pathways. Additionally, co-expression network and function analysis identified the potential lncRNAs related to inflammatory response and immune response. The expression of eight lncRNAs (ENSSSCT00000045208, ENSSSCT00000051636, ENSSSCT00000049770, ENSSSCT00000050966, ENSSSCT00000047491, ENSSSCT00000049750, ENSSSCT00000054262 and ENSSSCT00000044651) was validated in the LPS- treated and non-treated PBMCs by quantitative real-time PCR (qRT-PCR). In LPS-challenged piglets, we identified that three lncRNAs (ENSSSCT00000051636, ENSSSCT00000049770, and ENSSSCT00000047491) were significantly up-regulated in liver, spleen and jejunum tissues after LPS challenge, which revealed that these lncRNAs might be important regulators for inflammation .Conclusion: This study provides the first lncRNA and mRNA transcriptomic landscape of LPS-mediated changes in porcine PBMCs. These findings may provide potential insights into lncRNAs involved in regulating immune and inflammation in pigs.
An eHealth-based intervention against metabolic risks during pregnancy: learnings and challenges
Authors: Wang Xiaochun , Huang Nan , Hua Qiao , Zhang Dongtao , Li Guanghui , Fan Ling , Shi Gui , Liu Jun , Jin Yafang , Ma Hehe , Yuan Yana , Zhong Xuefeng 
Published: August 2020

Abstract
Background

Excessive gestational weight gain (eGWG) is one of the major metabolic risks for fetal macrosomia, maternal overweight, gestational diabetes mellitus (GDM), and gestational hypertension during pregnancy, which also increase the risk of postpartum weight retention. Gestational weight gain (GWG) management is rising to be attractive during prenatal care, however, there is still lack of effective tools to assist health care providers (HCPs) to efficiently and continuously implement intervention and monitor from the early phase of pregnancy. The current study tested a prototype eHealth solution aiming to assist clinicians to prevent eGWG and associated gestational metabolic complications.
Methods

A randomized controlled study was conducted in a private hospital in Beijing, China, with control group (N = 181) and intervention group (N = 181) recruited in rolling fashion. The control group received standard prenatal care, while the intervention group was additionally provided with the integrated prenatal care eHealth solution, Pregnancy Butler, which includes mobile application-enabled on-line service and off-line consultation session. The prevalence of eGWG, associated metabolic health parameters, and final pregnancy outcome were evaluated.
Results

Although mostly with normal pre-pregnancy BMI, the incidence for eGWG was high among the study subjects, at 35%. Engagement with the eHealth platform of the intervention group was stable after initial phase, but less than desired. Pregnancy Butler intervention showed significant benefit (p-value = 0.0496) in preventing eGWG among obese and overweight subjects. And highly engaged active users in the intervention group had more favorable GWG classification (p-value = 0.022). The time-course data collected indicated that the metabolic risks were largely set early in the first trimester already.
Conclusions

Our preliminary results indicated that the effectiveness of the eHealth intervention considerably depend on each participant’s engagement level and baseline risk factors. In order to achieve more consistent and impactful outcome improvement, focusing on those with pre-existing metabolic risks, increasing engagement and adherence level, and emphasizing intervention from the first trimester could be promising directions.
Trial registration:

This study was retrospectively registered as “Pregnancy Butler for gestational weight gain management” (ChiCTR1800014647) under the China Clinical Trial Registry in 2018-Jan-26. http://www.chictr.org.cn/showprojen.aspx?proj=24171
The Assessment of General Movements in Term and Late-Preterm Infants Diagnosed with Neonatal Encephalopathy, As a Predictive Tool of Cerebral Palsy by Two Years of Age - A Scoping Review.
Authors: Seesahai Judy , Rotter Thomas , Luther Maureen , Maddalena Patricia , Church Paige Terrien , Asztalos Elizabeth , Banihani Rudaina 
Published: August 2020

Abstract
BACKGROUND The General Movements Assessment is a non-invasive and cost-effective tool with demonstrated reliability for identifying infants at risk for cerebral palsy. Early detection of cerebral palsy allows for implementation of early intervention, and is associated with better functional outcomes. No review to date has summarized the utility of the General Movements Assessment to predict cerebral palsy in term and late-preterm infants diagnosed with neonatal encephalopathy and so detect the research gaps. METHODS We conducted a systematic scoping review for data on sensitivity, specificity, positive and negative predictive value and described the strengths and limitations of the results. We searched five databases (MEDLINE, Embase, PsychINFO, Scopus and CINAHL). Two reviewers conducted all screening and data extraction independently. The articles were categorized according key findings and a critical appraisal performed.RESULTS From the electronic database search, only two studies, case series, met all of the inclusion criteria. The total number of participants were 60. Neither of the final eligible studies included late-preterm neonates. Both studies reported on sensitivity, specificity, positive predictive and negative predictive value. The newer study reported that in the time period between term and 4-5 months post-term, that any cramped synchronized movements in this time period had results of 100% sensitivity and variable results for specificity, positive predictive value and negative predictive value. Neither of the studies had infants that received therapeutic hypothermia for Neonatal Encephalopathy. CONCLUSIONS The finding of cramped synchronized General Movements is a strong predictor of cerebral palsy by two years of age in the term population. Neonatal encephalopathy has an effect on spontaneous movements in term infants, be it transient or persistent. The predictive ability of spontaneous movements is very accurate when assessed early but improves when done later (at 15-22 weeks of age). A deficit of research exists with regards to cerebral palsy prediction using general movements in term and late-preterm infant with encephalopathy, especially when therapeutic hypothermia is instituted. Systematic review registration Title registration with Joanna Briggs Institute. URL: http://joannabriggs-webdev.org/research/registered_titles.aspx
Massage Therapy in Infants and Children under 5 Years of Age: Protocol for an Overview of Systematic Reviews and A Systematic Review
Authors: CHEN Shucheng , Yu Juan , Yuen Sam Chun-Sum , Lam Jason Chun-Sing , Suen Lorna Kwai-Ping , Yeung WF 
Published: August 2020

Abstract
Introduction: Massage is a popularly used complementary and alternative therapy. Previous randomised controlled trials have examined the effects of massage on children, and several systematic reviews have been conducted to synthesise these data. This study aims to assess and summarise the current evidence from published systematic reviews of controlled clinical trials on the practice of paediatric massage, specifically in infants and children aged < 5 years. Methods and analysis: This protocol was developed based on the Cochrane Handbook of Systematic Reviews of Interventions and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols. The online databases MEDLINE, Embase, Health Technology Assessment Database, Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects, Allied and Complementary Medicine, China National Knowledge Infrastructure, and Wanfang Data will be searched from the inception to June 2020 for evidence of the treatment effects. We will include systematic reviews of randomised control trials in infants and children aged < 5 years. Two reviewers will independently screen the articles for inclusion as per the eligibility criteria. They will extract information from the included studies and assess the methodological quality of the included studies. In addition, a systematic review of the adverse effects of massage on infants and children aged < 5 years will be included in this overview. We will present the treatment effects and adverse effects narratively. The pooled effect estimates for meta-analysed outcomes from the included studies will be extracted when possible. Additionally, we will generate a figure to show the recommendation level of massage therapy for each condition included according to the evidence quality of the studies included in the systematic reviews.Discussion: This overview of systematic reviews will summarise the current evidence on massage, specifically for infants and children aged < 5 years. We will comprehensively present the positive effects and adverse effects of this intervention.Trial registration number: CRD42020186003
The Possible Roles of Long Non-Coding RNAs FOXD2-AS1 and LINC00968 in Breast Cancer: Case-Control Study and in Silico Analysis
Authors: Arabpour Maedeh , Layeghi Sepideh Mehrpour , Majidzadeh-A Keivan , bazzaz Javad Tavakkoly , Naghizadeh Mohammad Mehdi , Shakoori Abbas 
Published: August 2020

Abstract
Background: Breast Cancer (BC) is the most common cancer in women worldwide. Long non-coding RNAs (lncRNAs) are regulatory non-coding transcripts and longer than 200 nucleotides. lncRNAs can affect many biological and pathological processes and dysregulation of them is related and studied in many human diseases like, cancers. We performed this study to evaluate the probable functions of lncRNAs FOXD2-AS1 and LINC00968 in breast cancer. Methods: The tumor tissue and adjacent non-tumor tissue specimens of luminal A and B breast cancer (the most frequent subtypes of breast cancer) were used to analyze the expression of these two lncRNAs, using the qRT-PCR technique. Furthermore, two luminal A breast cancer cell lines, MCF7 and T47D, were used to evaluate the expression of FOXD2-AS1 and LINC00968 compared with control breast cell line, MCF10A. Because of the luminal subtypes are the most frequent subtypes of breast cancer and also the most common subtypes among breast cancer patients, the present study was generally focused on the luminal and breast cancer. Also, some in silico analyses were done according to some databases and software for better understanding about the potential functions of mentioned lncRNAs in breast cancer. Results: Our data indicated the significant upregulation and downregulation of FOXD2-AS1 and LINC00968, respectively, in tumor tissues and breast cancer cell lines (MCF7, T47D). The bioinformatic analyses confirmed the experimental results. FOXD2-AS1 expression was positively associated with p53 protein and LINC00968 expression was negatively associated with tumor stage and lymph node metastasis. According to our findings, LINC00968 might be function as a tumor suppressor gene in breast cancer and this lncRNA might function in some cellular signaling pathways, like PI3K/Akt and Ras signaling pathways based on the co-expressed genes, but more investigations are required. Conclusions: The two mentioned lncRNAs might play roles in breast cancer pathogenesis but more experimental studies are needed to explore the mechanisms of the functions of these two lncRNAs in breast cancer.
Diaphragm reconstruction by GORE DUALMESH in patients undergoing resection for thoracic malignancies
Authors: Sano Atsushi , Azuma Yoko , Sakai Takashi , Koezuka Satoshi , Otsuka Hajime , Iyoda Akira 
Published: August 2020

Abstract
BackgroundWe used GORE DUALMESH for the reconstruction of diaphragms in patients with thoracic malignancies. Here, we report the results.MethodsBetween July 2015 and August 2017, diaphragm reconstruction using 2-mm GORE DUALMESH was performed in 7 patients undergoing surgical resection for thoracic malignancies. After resection of the diaphragm, the mesh was trimmed to the size of defect and placed with the smooth surface facing the chest cavity and the rough surface facing the abdomen. It was fixed with interrupted sutures consisting of synthetic monofilament nonabsorbable 1-0 to 2 threads.ResultsIndications for resection were malignant mesothelioma and primary lung cancer in 5 and 2 patients, respectively. Patients with malignant mesothelioma underwent pleurectomy with decortication; patients with primary lung cancer underwent lung lobectomy. Right and left diaphragm reconstruction was performed for 4 and 3 patients, respectively. Neither complications related to diaphragm reconstruction nor displacement of mesh occurred during a follow-up period ranging from 11 days to 37 months.ConclusionsGORE DUALMESH is a good synthetic material for diaphragm reconstruction, because its smooth surface prevents adhesions to the lung and its rough surface allows adherence to abdominal tissue.
Bariatric Orthopaedics: Impact of Obesity on Total Knee Replacement
Authors: Butt Ahsan , Zain-ur-Rehman Muhammad , Nawab Adeel , Hafeez Ahmad , Amjad Ali 
Published: August 2020

Abstract
Introduction: Total knee replacement is a reliable operation for reducing pain and improving function in severe osteoarthritis of the knee. As incidence of obesity is increasing worldwide, there is a debate about the role of Body Mass Index (BMI) in selection of patients requiring total knee replacement. The aim of the study was to evaluate the impact of body mass index on total knee replacement in terms of post-operative improvement in knee range of motion, patient satisfaction and complications.Material and methods: Out of 175 patients who suffered from advance knee osteoarthritis and were candidates for primary total knee replacement from January 2016 to March 2018, 155 patients fit the inclusion criteria. Group 1 included 66 patients who were overweight and class 1 obese while group 2 included 89 patients who were class 2 and 3 obese according to WHO Body Mass Index classification. All patients underwent total knee replacement according to the hospital guidelines. Pre and post-operative range of motion, patient satisfaction and complications were assessed and documented. Results: There was no statistically significant difference in improvements in post-operative knee range of motion between the two groups up to 2 years of follow up. [Mann-Whitney U test p= 0.069]. Similarly, Mann-Whitney U test showed that there is no significant difference between patient satisfaction levels (SF-12 scores) of the two groups (p= 0.09). Conclusion: There is no significant impact of obesity on outcomes after total knee replacement and BMI should not be used as a factor in selecting patients who qualify for total knee replacement.Level of Evidence: Level III
The Optimal Arthroscopic Release Plane of External Snapping Hip
Authors: Zhu Min , Xue Chao , Song Mengxiong , Cai Qiuchen , Cheng Biao , Chen FuBo , Wu Peng 
Published: August 2020

Abstract
Background: Some studies have reported arthroscopic release of external snapping hip(ESH). However, there is no research on the effect of different arthroscopic release plane for ESH. We will study the effect of release plane on arthroscopic surgery, and suggest an optimal release plane.Methods: From September 2017 to December 2018, 177 bilateral and 6 unilateral ESH patients who would receive arthroscopic release of ESH and agree to attend at this study were enrolled. One release plane was randomly offered for each operation hip out of 6 different arthroscopic release planes(referred to the apex of the great trochanter(GT), including planes of -2cm, 0cm, 2cm, 4cm, 6cm and 8cm groups). All patients received continuous follow-up, comparing preoperative and postoperative hip snapping, hip adduction and flexion angles and Harris Hip Scores(HHS). Results: There was no difference in age, gender, body mass index (BMI) and average operation time among different release plane groups (p>0.05). In terms of surgical success rate, the release plane group 4cm (98.33%)> 6cm (96.67%)> 2cm (95.00%)> 0cm (91.67%)> 8cm (8.33%)>-2cm (5.00%) (p<0.05). Although the hip adduction and flexion angles were improved in each group after operation (p<0.05), the improvement in the release plane -2cm and 8cm groups was significantly lower than that in the other four release plane groups (p<0.05). In addition, at 12 months of follow-up, all patients had significantly improved adduction and flexion angles and HHS (p<0.05). Conclusions: The arthroscopic release plane for ESH can affects the surgical effect, and the optimal arthroscopic release plane is 0-6 cm .