bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variable selection for high-dimensional quadratic Cox model with application to Alzheimer’s disease
Authors: Li Cong , Sun Jianguo 
Published: May 2020

Abstract
This paper discusses variable or covariate selection for high-dimensional quadratic Cox model. Although many variable selection methods have been developed for standard Cox model or high-dimensional standard Cox model, most of them cannot be directly applied since they cannot take into account the important and existing hierarchical model structure. For the problem, we present a penalized log partial likelihood-based approach and in particular, generalize the regularization algorithm under marginality principle (RAMP) proposed in Hao et al. (J Am Stat Assoc 2018;113:615–25) under the context of linear models. An extensive simulation study is conducted and suggests that the presented method works well in practical situations. It is then applied to an Alzheimer’s Disease study that motivated this investigation.
„Aber es ist insgesamt zu wenig und es fehlt ein klares Konzept“ ‒ Willkommensklassen in Berlin
Authors: Gamper Jana , Röttger Evelyn , Steinbock Dorotheé , Falke Ulrich 
Published: May 2020

Zusammenfassung
Schulpflichtige Sprachanfänger/innen des Deutschen werden in Berlin in sogenannten Willkommensklassen unterrichtet. Trotz langjähriger Erfahrung mit dieser Beschulungsform fehlen konkrete Vorgaben und Konzepte für eine erfolgreiche Integration von Schüler/innen und Lehrkräften. Die im Beitrag vorgestellte Online-Befragung von 315 Berliner Willkommensklassenlehrkräften aller Schulformen bestätigt diese Auffassung in Teilen und bietet einen differenzierten Einblick zu Bedarfen und Mängeln.
Zur Situation der Beschulung neu zugewanderter Schüler/innen
Authors: Erichsen Göntje 
Published: May 2020

Zusammenfassung
Je nach Bundesland und Schule ist die Beschulung neu zugewanderter Schüler/innen strukturell unterschiedlich organisiert. Im vorliegenden Beitrag wird diese Organisation exemplarisch anhand eines nordrhein-westfälischen Gymnasiums gezeigt. Hierzu werden im Sinne der Situationsanalyse relevante menschliche Akteur/innen und nicht menschliche Aktanten identifiziert und miteinander in Beziehung gesetzt. Dabei kann die Vernetzung der unterschiedlichen Akteur/innen und Aktanten und somit die Komplexität des Gefüges aufgezeigt werden.
Making cross-cultural meaning in five Chinese promotion clips: Metonymies and metaphors
Authors: Guan Yue , Forceville Charles 
Published: May 2020

AbstractMetonymy and metaphor are fundamental and ubiquitous meaning-generating tropes that operate on a conceptual, not just a verbal, level. The goal of this paper is to demonstrate to scholars outside of the Conceptual Metaphor Theory and Conceptual Metonymy paradigm how these two tropes cue meaning verbally, visually, musically, sonically, and multimodally in five Chinese clips promoting Chinese cities and Chinese trade fairs, all produced after, and in the spirit of, president Xi Jinping’s “Belt and Road” initiative (2013). We also pay attention to how interpretations are to some extent bound to differ depending on whether the audience does or does not have detailed knowledge of Chinese culture. We end by briefly arguing that a full analysis of the clips – as indeed of most discourses – requires awareness of yet other tropes as well as expertise in other humanities disciplines.
Transforming linear time-varying optimal control problems with quadratic criteria into quadratic programming ones via wavelets
Authors: Malmir Iman , Sadati Seyed Hossein 
Published: May 2020

Abstract
In this paper, an algorithm for solving optimal control of linear time-varying systems with quadratic performance indices is presented. By using important matrices which are derived from Chebyshev wavelets properties, the original problem is converted to a quadratic programming one. This parameter optimization method is applied on both constrained and unconstrained control systems having linear state equations of integer and fractional orders. The computing time saved by this approach is much better than with other methods in which there is no need to calculate the optimal costs of systems by substituting the approximations of the state and control vectors
and their values are default outputs of the quadprog solvers.
Antiproliferative effects of combinational therapy of Lycopodium clavatum and quercetin in colon cancer cells
Authors: Banerjee Antara , Pathak Surajit , Jothimani Ganesan , Roy Susmita 
Published: May 2020

Abstract

Background
Colorectal cancer (CRC) is the third most prevalent form of cancer and fourth leading cause of morbidity worldwide. Surgical resection remains the only curative approach for CRC, but recurrence following surgery is the main problem and ultimate cause of death. Lycopodium clavatum and quercetin have been found to exert its anticancer properties. The aim of the present study is to investigate whether quercetin or L. clavatum extract and combination of both have any profound role in reducing major inflammatory cytokines in Colo-320 cells.

Methods

L. clavatum and Quercetin alone or in combination was administered to colon cancer cells and various toxicity markers, gene expression analyses of apototic genes and gelatin zymmography were performed.

Results
Quercetin (50 μm) in combination with L. clavatum extract (10 μL) distinctly reduced cell growth and highlighted their potential effects in extirpation of colon cancer cells. Treatment with increased dose of L. clavatum extract in combination with quercetin reduced the colony size and proliferation potential when compared to the sole treatment of plant extracts. In the antimicrobial assays, it was observed that Lycopodium alone exhibited antimicrobial activity against Escherichia coli and Pseudomonas aeruginosa. Characterization of L. clavatum extract and quercetin was performed and confirmed the presence of flavonoids and alkaloids. Treatment with Lycopodium and quercetin combination induced significant down-regulation in activities of MMP2 and MMP9 tested by gelatin zymography. The combined treatment greatly affected the mRNA expression of p53, Bcl2, Bax, Caspase 3, Wnt 1, Cyclin D1, and Catalase genes in colon cancer cells.

Conclusion
The synergistic effect between Lycopodium and quercetin might bring forward the enhanced antitumorigenic properties of combinational therapy with natural products to successfully combat the cancer progression with minimal side effects and resistance to drugs.
Lithotriptic effect of Safūf Hajar-al Yahūd in patients of Hasat-ul Kilya (Nephrolithiasis) – an open prospective clinical validation trial
Authors: Ahmed Noor Zaheer , Ahmed Kabiruddin , Anwar Noman , Ezhil Radhakrishnan , Anjum Nighat , Khan Asim Ali 
Published: May 2020

Abstract

Background

Hasat-ul Kilya (Nephrolithiasis) is one of the most common chronic conditions and has been known to the mankind since antiquity. The incidence is increasing globally with geographic, racial and gender variation in its occurrence. Medical management of Nephrolithiasis still poses a considerable challenge for modern medical practice. Unani drugs possessing lithotriptic activity are not only cost effective but also have least side effects. Safūf Hajar-al Yahūd has been used since long for the treatment of Hasat-ul Kilya (Nephrolithiasis) but no documentary evidence based on scientific parameters as to its safety and efficacy are available.

Objective
To validate the safety and efficacy of Safūf Hajar-al Yahūd in the treatment of Hasat-ul Kilya.

Methodology
An open prospective clinical trial was carried out on 107 subjects of renal calculi of 3–7 mm diameter diagnosed by Ultrasonogram-KUB (USG-KUB). Subjects were evaluated by clinical history & examination, laboratory investigations followed by USG-KUB for confirmation. The safety was assessed by reporting of adverse events and by pathological and biochemical investigations. Assessment of efficacy was based on improvement observed in VAS score and expulsion/reduction of stone size as detected by USG-KUB.

Results
Substantial reduction (53%) in the size of calculi confirmed by USG-KUB and considerable lowering of VAS score (75%) were observed with the active intervention in majority of the cases

Conclusion
The trial has revealed that the Unani pharmacopoeal formulation Safūf Hajar-al Yahūd was well tolerated and has the therapeutic potential in the reduction and expulsion of renal calculi.
Shaping the Profession: Some Thoughts on Office, Duty, and the Moral Problematisation of Professional Activities in the Counter-Reformation
Authors: Faitini Tiziana 
Published: May 2020

Abstract
This paper investigates the theorisation of the duties belonging to different – both lay and professional – conditions, elaborated upon by post-Tridentine moral theology, in order to highlight its contribution to the modern conceptualisation of the profession, and, more generally, to modern economic and political rationality. It focuses particularly on how work and professional activities are dealt with in Juan Azor’s Institutiones morales, Hermann Busenbaum’s Medulla theologiae moralis and Alfonso de Liguori’s Theologia moralis, between the early seventeenth and mid-eighteenth centuries. The paper begins with some quick historical remarks on the theological elaboration on the states of life (in the context of early-modern political and moral thought on duty and office) and the tradition de officiis underpinning these sources. The specific prescriptions imposed by these sources on professional activities in their discussions of the Third Commandment, and the obligation to rest or fast on certain days, are then examined. A brief analysis of the paragraphs explicitly devoted to the duties of professionals (legal and health professionals in particular) precedes some final observations about the post-Tridentine model of profession and its influence on the moral and socio-political valorisation of professional activities.
Additivity of the algebraic entropy for locally finite groups with permutable finite subgroups
Authors: Giordano Bruno Anna , Salizzoni Flavio 
Published: May 2020

Abstract
Additivity with respect to exact sequences is, notoriously, a fundamental property of the algebraic entropy of group endomorphisms.
It was proved for abelian groups by using the structure theorems for such groups in an essential way.
On the other hand, a solvable counterexample was recently found, showing that it does not hold in general.
Nevertheless, we give a rather short proof of the additivity of algebraic entropy for locally finite groups that are either quasihamiltonian or FC-groups.
Sociolinguistics and history: An interdisciplinary view of bilingualism in imperial Russia
Authors: Offord Derek 
Published: May 2020

AbstractUsing a study of the historical phenomenon of Franco-Russian bilingualism in imperial Russia as its point of departure, this article has three interlocking aims. First, it reflects on the common interest that historical sociolinguists and certain types of historian have in language use and language choice. Secondly, building on recent work by historical sociolinguists, it considers the ways in which historians’ and historical sociolinguists’ investigation of such matters as the social, political, cultural and literary functions of the French language in lands where French was not the mother tongue can be broadened and deepened by familiarity with each others’ findings. Thirdly, it seeks to illuminate the role of linguistic meta-discourse in the sort of grand narratives about the history and culture of national communities in which historians may be interested. In the specific case I examine, the narratives concern the relationship of Russia to the West, the wholeness or fragmentation of the Russian nation, the effects of cultural borrowing, the nature of Russian national identity and culture and the degree to which Russia is historically and culturally exceptional. In pursuit of these aims, I hope to illustrate the importance of linguistic matters in the history of societies, polities, and cultures and the potential that an interdisciplinary approach has to lend scholarship on these matters richer context and finer nuance than work which falls purely within either the historical or the historical-sociolinguistic domain tends to yield.
A non-iterative method for recovering the space-dependent source and the initial value simultaneously in a parabolic equation
Authors: Wang Zewen , Chen Shuli , Qiu Shufang , Wu Bin 
Published: May 2020

Abstract
This paper is concerned with the inverse problem for determining the space-dependent source and the initial value simultaneously in a parabolic equation from two over-specified measurements. By means of transforming information of the initial value into the source term and obtaining a combined source term, the parabolic equation problem is converted into a parabolic problem with homogeneous conditions. Then the considered inverse problem is formulated into a regularized minimization problem, which is implemented by the finite element method based on solving a sequence of well-posed direct problems. The uniqueness of inverse solutions are proved by the solvability of the corresponding variational problem, and the conditional stability as well as the convergence rate of regularized solutions are also provided. Then the error estimate of approximate regularization solutions is presented in the finite-dimensional space. The proposed method is a very fast non-iterative algorithm, and it can successfully solve the multi-dimensional inverse problem for recovering the space-dependent source and the initial value simultaneously. Numerical results of five examples including one- and two-dimensional cases show that the proposed method is efficient and robust with respect to data noise.
FEM-based Scalp-to-Cortex EEG data mapping via the solution of the Cauchy problem
Authors: Koshev Nikolay , Yavich Nikolay , Malovichko Mikhail , Skidchenko Ekaterina , Fedorov Maxim 
Published: May 2020

Abstract
We propose an approach and the numerical algorithm for mapping the electroencephalographic (EEG) data from the scalp to the cortex. The algorithm is based on the solution of ill-posed Cauchy problem for the Laplace’s equation using
tetrahedral finite elements. The FEM-based scheme allows to calculate the volumetric distribution of a potential over the head
volume. We demonstrate the usage of the the algorithm for accurate estimation of the depth of
electric sources in the head. The algorithm sufficiently increases the spatial
resolution of the EEG technique making it comparable with intracranial techniques.
Inborn errors of metabolism detectable by tandem mass spectrometry in Beijing
Authors: Yang Nan , Gong Li-fei , Zhao Jin-qi , Yang Hai-he , Ma Zhi-jun , Liu Wei , Wan Zhi-hui , Kong Yuan-yuan 
Published: May 2020

AbstractBackgroundIndividual inborn errors of metabolism (IEMs) are rare disorders. Expanded newborn screening for IEMs by tandem mass spectrometry (TMS) is an efficient approach for early diagnosis. Here we provide the newborn screening program for the application of this approach (between July 2014 and March 2019) to the identification of newborns in Beijing at risk of developing a potentially fatal disease.MethodsThe amino acids and acylcarnitines in dried blood spots were analyzed by TMS. Diagnoses of newborns with elevated metabolites were confirmed by gas chromatography-mass spectrometry, biochemical studies, and genetic analysis.ResultsAmong the healthy newborns, 16 metabolic disorder cases were confirmed, giving a total birth prevalence of 1:3666 live births. Organic acidemia (OA) was the most common (9/16 patients; 56%), and methylmalonic acidemia was the most frequently observed OA (7/9 patients; 89%). Five infants were diagnosed with methylmalonic acidemia with homocystinuria type CblC, two with isolated methylmalonic acidemia, one with propionic acidemia, and one with isovaleric acidemia. Four patients (4/16, 25%) were diagnosed with hyperphenylalaninemia. One suffered with medium-chain acyl CoA dehydrogenase deficiency, one with carnitine uptake deficiency, and one with citrin deficiency. Eleven cases underwent genetic analysis. Seventeen mutations in eight IEM-associated genes were identified in 11 confirmed cases. Symptoms were already present within 2 days after birth in 44% (7/16) cases. The infant with propionic acidemia died at 7 days after birth. The other cases received timely diagnosis and treatment, and most of them grew well.ConclusionsThe results illustrate challenges encountered in disease management highlighting the importance of newborn screening for inherited metabolic disorders, which is not yet nationally available in our country. Regional newborn screening programs will provide a better estimation of the incidence of IEM.
Growth status of children and adolescents born small for gestational age at full term in Korea: data from the KNHANES-V
Authors: Kim Ji Hyun , Kim Dong Ho , Lim Jung Sub 
Published: May 2020

Abstract

Objectives
Small for gestational age (SGA) status is known to show stunted growth and results in short stature in adults. The aim of this study was to describe the current short stature in subjects born SGA in Korea and to assess catch-up growth (CUG) or non-CUG.

Methods
We analyzed data from 3,524 subjects (1,831 male) aged 1–18 years who were born as full-term singletons and who participated in the Fifth Korean National Health and Nutrition Examination Survey (2010–2011).

Results
The prevalence of SGA was 13.4% (n=471). Subjects born SGA had fathers with shorter height, shorter mother’s height, and mid-parental height than non-SGA subjects (p<0.05 for all). The odds ratios (ORs) for SGA birth of a short statured father and a short statured mother were 2.00 (95% CI; 1.15–3.47) and 2.11 (95% CI; 1.30–3.40), respectively. Among 471 SGA subjects, 28 subjects (5.9%) were non-CUG, which made up 36.4% of all subjects with short stature. The CUG subjects had a higher father's height, mother’s height, mid-parental height, and current BMI (p<0.05 for all). The non-CUG subjects had a higher percentage of fathers being near-short stature (height<10th percentile; 33.3 vs. 12.7%; p=0.008) and mothers being near-short stature (39.3 vs. 13.9%; p<0.001).

Conclusion
Korean subjects born SGA had a higher risk of current short stature. This population-based nationwide survey also showed that both father’s and mother’s short stature are risk factors of not only SGA birth but also non-CUG in their children.
Investigating the preventive effect of vitamins C and E on preeclampsia in nulliparous pregnant women
Authors: Lorzadeh Nahid , Kazemirad Yasaman , Kazemirad Nastran 
Published: May 2020

Abstract

Objectives
Preeclampsia is a hypertensive disorder associated with pregnancy and is the leading cause of both maternal and neonatal morbidity and mortality. Recent reports suggest that free radical-induced endothelial cell injury might be an etiologic factor in the pathogenesis of preeclampsia. The aim of this study was to determine the protective effects of vitamins C and E for the prevention of preeclampsia.

Methods
This clinical trial was conducted in the year 2018 in the clinical centers of Lorestan University of Medical Sciences. One hundred and sixty nulliparous women aged 18–38 years without any risk factors for preeclampsia were divided into two groups. The first group received a 400-IU/day dose of vitamin E orally and a 1000-mg/day dose of vitamin C with iron tablets during 20–24 weeks of pregnancy, while the control group received only iron tablets. Finally, the data were analyzed using descriptive statistics and frequency distribution tables.

Results
The incidence of preeclampsia in the control group was 17.5% and in the intervention group was 5%, which was significantly different. The mean systolic pressures before and after intervention were 99.43 ± 7.8 and 12.44 ± 19.1, respectively, in the control group, and 99.3 ± 8.3 and 106.12 ± 13.25, respectively, in the intervention group (P < 0.001). The mean diastolic pressures before and after intervention in the control group were 62.7 ± 13.6 and 62.7 ± 4.7 (P < 0.001), respectively.

Conclusion
The results of this study show that vitamins C and E have protective effects against preeclampsia by alleviating the overall blood pressure.
A neural network assisted Metropolis adjusted Langevin algorithm
Authors: Müller Christian , Diedam Holger , Mrziglod Thomas , Schuppert Andreas 
Published: May 2020

Abstract
In this paper, we derive a Markov chain Monte Carlo (MCMC) algorithm supported by a neural network.
In particular, we use the neural network to substitute derivative calculations made during a Metropolis adjusted Langevin algorithm (MALA) step with inexpensive neural network evaluations.
Using a complex, high-dimensional blood coagulation model and a set of measurements, we define a likelihood function on which we evaluate the new MCMC algorithm.
The blood coagulation model is a dynamic model, where derivative calculations are expensive and hence limit the efficiency of derivative-based MCMC algorithms.
The MALA adaptation greatly reduces the time per iteration, while only slightly affecting the sample quality.
We also test the new algorithm on a 2-dimensional example with a non-convex shape, a case where the MALA algorithm has a clear advantage over other state of the art MCMC algorithms.
To assess the impact of the new algorithm, we compare the results to previously generated results of the MALA and the random walk Metropolis Hastings (RWMH).
Myocardial amyloidosis following multiple myeloma in a 38-year-old female patient: A case report
Authors: Zhang Qisi , Qiao Yingli , Yan Dongmei , Deng Yuhui , Zhang Mengyang , Xu Poshi 
Published: May 2020

Abstract
Multiple myeloma (MM) is an immunoglobulin-producing tumor of plasma cells, which occurs commonly in the elderly. The incidence of myocardial amyloidosis with MM is extremely low and early clinical manifestations are nonspecific. The diversity of clinical manifestations and first episode symptoms often cause misdiagnosis in young patients with myocardial amyloidosis following MM. In this study, we analyzed the clinical data of a young woman with MM and impaired cardiac function combined with echocardiography, electrocardiography (ECG), laboratory data, cell Congo Red staining, and other manifestations to diagnose amyloidosis. Considering the rapid progression, short survival, and poor prognosis in most patients, a clear, definitive, and timely diagnosis is essential for the treatment of patients with MM complicated with myocardial amyloidosis.
The Russian Edition of Johann Jacobi von Wallhausen’s »Kriegskunst zu Fuß« (1649): The History of A Failure?
Authors: Rusakovskiy Oleg 
Published: May 2020

Abstract
The article deals with the history of the »Uchenie i khitrost’ ratnogo stroeniia pekhotnykh liudeĭ« – the first Russian book on military art issued in print in Moscow in 1649. Being a full and exact translation of the »Kriegskunst zu Fuß« by Johann Jacobi von Wallhausen (1615), the »Uchenie« has for a long time been recognized by historians as the first Russian effective drill manual which played an important role in the modernization of infantry tactics and military training. However, the use of the book for and during drill sessions could not be inferred by existing sources. Wallhausen’s text was too voluminous and comprehensive in comparison with contemporary drill manuals and could scarcely be understood by uneducated Russian readers. Tactical formations prescribed by Wallhausen were outdated and not suitable for the conditions prevailing in the Eastern European warfare of the mid-17th century. As a result, the book considered as being quite important for Russian culture had no value for military developments of the time.