bluuebunny/crossref_metadata_2025_split huggingface dataset:
Features of basic indicators of oral fluid in children after hematopoietic cell transplantation (pilot study)
Authors: Koren N. A. , Tkachenko T. B. , Vladimirova L. G. , Abdullaeva Sh. R. , Semenova E. V. 
Published: March 2020

Relevance. Treatment of patients with refractory forms of acute lymphoblastic leukemia causes a number of complications from the organs and tissues of the oral cavity. It can be both early complications – cytotoxic reactions with the development of oral mucositis, and late, leading to a violation of the mineralization of hard tooth tissues, and to underdevelopment of the teeth. Oral fluid plays an important role in maintaining oral homeostasis. One of the most important functions that it performs is maintaining the physiological balance of the processes of re- and demineralization of tooth enamel. Since demineralization processes begin in childhood at higher pH values than in adults, when the hydrogen index decreases below 6.4, demineralization processes begin to prevail over remineralization, and the solubility of hydroxylapatite crystals which enamel consists of increases.The objective was to assess the basic indicators of oral fluid and oral hygiene indices in this group of patients.Methods and materials. During the examination of the oral cavity, the intensity of caries and hygiene indices were determined. For the study, oral fluid was collected, followed by determination of its viscosity and hydrogen index.Results. These patients showed a lower level of oral fluid hydrogen index and a lower level of oral hygiene compared to healthy children. In addition, during the study, it was found that there is a direct relationship between the pH of the oral fluid and the time elapsed since the hematopoietic cell transplantation.Conclusion. The detected changes are factors that predispose to an increase in the intensity of caries, and require early preventive measures.Authors declare no conflict of interest.The authors confirm that they respect the rights of the people participated in the study, including obtaining informed consent when it is necessary, and the rules of treatment of animals when they are used in the study. Author Guidelines contains the detailed information.
Strategi Komunikasi Politik Partai Baru (Studi Kasus Perolehan Suara Partai Solidaritas Indonesia di DPRD DKI Jakarta Pada Pemilu 2019)
Authors: Moneter Bella Adha Hendriana , Susanto Eko Harry 
Published: March 2020

The 2019 legislative elections participated by many political parties in Indonesia, one of which was the Indonesian Solidarity Party (PSI). The more parties that participate in the General Election, the competition between each one of them become more strict in order to get a seat in parliament. Due to that reason, PSI did not pass on the DPR RI election level but somehow managed to get a 6.68% vote and get eight seats on the Jakarta DPRD election level. In this case, the purpose of this research is to study the political communication strategy of PSI Jakarta regarding the vote they got on Jakarta DPRD election level in 2019 General Election. This research is using the conceptualization of political policy, the conceptualization of political communication strategy, conceptualization of political policy, and conceptualization of political policy. political policy, and conceptualization of general elections as the theoretical basis. The research method in this research is a case study and the research approach in this research is descriptive-qualitative. The conclusion of this research shows that the political communication strategy used by PSI Jakarta to gain votes is by paying attention to the figures, stabilizing the institution, and creating togetherness. They also combined their politics communication strategy with the politics communication itself, in order to gain a lot more votes. Pemilu Legislatif Tahun 2019 diikuti banyak partai politik di Indonesia salah satunya partai baru, Partai Solidaritas Indonesia (PSI). Semakin banyak partai politik mengikuti Pemilu, semakin ketat kompetisi antar partai untuk mendapatkan kursi di parlemen. PSI tidak lolos memperebutkan kursi DPR RI, tetapi berhasil mendapatkan suara 6,68% atau delapan kursi di DPRD DKI Jakarta. Penelitian ini ingin mengetahui strategi komunikasi politik PSI Jakarta atas perolehan suara di DPRD DKI Jakarta pada Pemilu 2019. Landasan teoritik yang digunakan adalah konseptualisasi komunikasi politik, konseptualisasi strategi komunikasi politik, konseptualisasi partai politik, dan konseptualisasi pemilihan umum. Penelitian ini menggunakan pendekatan kualitatif deskriptif. Hasil penelitian menunjukkan strategi komunikasi politik PSI Jakarta untuk memperoleh suara yakni dengan merawat ketokohan, memantapkan kelembagaan, dan menciptakan kebersamaan. PSI Jakarta juga mengkombinasikan strategi komunikasi politik dengan unsur komunikasi politik.
Cultivating a Community of Practice through Podcasting
Authors: Zumach Gregory M. , Portillo Edward 
Published: March 2020

While innovation in pharmacy education can be sparked through many avenues, the opportunity to learn and engage with others through practice communities is considered by many as a creative outlet for exchange and discovery. This commentary specifically describes a contemporary approach to promote such a dialogue globally through podcasting, which is a free and highly accessible medium for dissemination and exchange of innovative teaching practices. In 2018, two faculty from two colleges of pharmacy created a podcast titled Leadership Development in Pharmacy Education (LDPEcast), which provides a unique modality to stimulate discussion and disseminate ideas within the community of practice. This commentary provides a case illustration for how a podcast can be intentionally designed and implemented with the goal of inspiring engagement across a global practice community. Early results of the podcast have been largely successful with nearly 1000 episode downloads and an additional 445 episode streams from audience members. While this podcast was designed specifically to discuss leadership integration within pharmacy training, opportunities may exist for further exploration of podcasting to spread innovative ideas, practices, and evaluative approaches in pharmacy education, while strengthening connections and elevating communities of practice across institutions.

Article Type: Commentary
The dark side of doing good: a qualitative study to explore perceptions of local healthcare providers regarding short-term surgical missions in Port-au-Prince, Haiti
Authors: Chaus Merrill 
Published: March 2020

Background In response to the increasing global burden of surgical diseases, medical providers from high-income countries are increasingly volunteering in underserved regions. Short-term surgical missions are growing in number but lack appropriate oversight. Many studies on volunteers’ perspectives have been published, but few have examined the perspectives of local healthcare providers. Aim To explore perceptions of Haitian healthcare providers regarding short-term volunteer missions in order to identify positive and negative perceptions. Methods A qualitative approach utilizing interpretivist epistemology and a social constructivist perspective captured perceptions of participants in their social setting. Interpretivism recognizes that perceptions are subjective and socially constructed. After purposive sampling, 17 participants were recruited. In-depth recorded interviews with assistance from local interpreters explored participants’ perceptions. Using thematic content analysis, unexpected themes emerged. Results Four themes emerged: general perceptions, perceived effect on healthcare system, perceived effect on healthcare workers, and future recommendations. In general, local healthcare workers appreciate the skills and knowledge that teams impart and the improved access to surgical services for the poor. However, volunteers working independent of local teams create negative perceptions, stress local healthcare providers, and strain hospital resources. Future teams should utilize local perceptions to measure impact and effectiveness of their efforts. Conclusions Perceived impact of short-term surgical missions is dependent on participant perspective. This study addresses negative perceptions and offers recommendations for before, during, and after a mission. Surgical missions that emphasize training local staff and forming long-term relationships have a greater impact on surgical capacity than do missions that focus primarily on surgical volume. Further research on local perceptions is essential to ensure that local voices continue to be heard and that altruistic efforts of volunteers do not inadvertently cause negative effects.
Effects of sixteen week of resistance exercises on some selected cognitive variables development in adolescents with intellectual disabilities
Authors: ZENEBE Kefelegn , LEGESSE Kesatie , MANDAL Soumitra , MAHMUD Mahmud , ARAGAW Kidanie 
Published: March 2020

Intellectual
disabilities a serious problem in the entire world and its prevalence is high
in school-age children. These difficulties can influence cognitive, social and
emotional areas of functioning and have led their families to suffer in economic
and social disadvantages than those without disabilities. The main objective of
this study was to investigate the effect of sixteen-week resistance exercise on
cognition developments of school children with intellectual disabilities in
Desse &amp; Kombolcha, Amhara region, Ethiopia. In this Pre-test and post-test study design, eighteen adolescents
with intellectual disabilities participated in the study. A paired t-test was fitted to analyze the pre-test and
post-test data of the study participants.
In order to measure cognitive variables digit span backward,
digit span forward, vocabulary and similarity test batteries were used to
measure working memory, short term memory, vocabulary knowledge and comparative
reasoning respectively before and after sixteen-week of the training
intervention. After sixteen-week of intervention, a
significant mean score change was
observed in working memory, short
term memory, vocabulary knowledge, and comparative reasoning respectively (p &lt; 0.05) after training when compared before training. We concluded that resistance exercise can improve the
cognitive skills of adolescents with intellectual disabilities.
The Current State of the Gamification in E-Learning
Authors: Rozman Tomislav , Donath Liliana 
Published: March 2020

The aim of this article is to present a systematic literature review of literature reviews (a meta-study) of gamification topics in e-learning with a purpose to present a high-level overview of the state of the development of the selected field.
The systematic literature review of literature reviews (2010 - 2019) was performed. The academic papers (literature reviews) from several academic databases such as DOAJ, ScienceDirect, Google Sholar and WOS were examined and filtered for further study. The selected articles were analysed for sub-topics (e.g. the efficiency of gamification mechanisms) and summarized.
In last 5 years, the research of gamification in various fields (mobile apps, e-health, human resource management, business development, e-learning) is getting traction and the number of research articles and systematic reviews of research articles is increasing. After filtering literature review articles, we have found out that only a handful of them – 19, which summarizes 2631 studies, are directly related to gamification in e-learning.
This study shows that the following gamification mechanisms in e-learning proved themselves efficient in almost all underlying studies, but there is no broad consensus on terminology and how to group of different gamification related concepts.
The research is limited to the following scholarly databases: DOAJ, Elsevier, Google Scholar, and WOS. We are aware that there is a possibility we missed some systematic literature reviews on this topic, which was indexed in other well-known databases or published using different terminology in the title or abstract.
The article can serve as a starting point for the research for the scholars and especially post-graduate students who are getting familiar with the e-learning, gamification and performing systematic literature reviews. Also, developers of e-learning systems and course designers could benefit from this article by finding out which gamification mechanisms are most researched, most efficient and worth implementing.
To our knowledge, this kind of meta-analysis of the literature reviews hasn’t been done in the field of gamification in e-learning for the year 2019.
The Impact of Personality Dimensions on Study Behaviour and Study Attitudes of Online Students
Authors: Divjak Marko , Prevolnik Rupel Valentina , Bartolj Tjaša 
Published: March 2020

The objective of this study was to evaluate the impact of the Big Five personality dimensions on study attitudes and study behaviour of online students. Based on theoretical background, we proposed and tested the model, which assumes significant direct impact of personality dimensions on study attitudes and study behaviour and a bi-directional relationship between study attitudes and study behaviour.
Partial analyses of the interrelationships proposed in the model showed that personality dimensions exert a more powerful direct impact on study behaviour than on study attitudes, with conscientiousness being the strongest predictor of study behaviour. When personality dimensions are controlled, there is a significant moderate interrelationship between study behaviour and study attitudes. This indicates that personality dimensions may influence study attitudes indirectly via study behaviour. The results of structural equation modelling (SEM) revealed insufficient empirical evidence to support the model as a whole, which questions the validity of the proposed model.
Comparative study of assortment of medical films presented in the pharmaceutical markets of Ukraine, USA and Poland
Authors: Demchuk M. B. , Groshovyi T. A. , Malanchyk N. V. 
Published: March 2020

The development of medical films containing active substances immobilized on polymeric carriers become significantly popular in the world. Medical films belong to the application forms and designed for injection of active pharmaceutical ingredients through the skin, periodontal tissue, the mucous membrane of the mouth. There are transdermal therapeutic systems, including buccal, dental and oral films. Pharmaceutical manufacturers present a wide range of medicinal films containing various active ingredients on the world market.
The purpose of our study was to conduct a comparison of the range of medicines in the form of medical films registered in the pharmaceutical markets of Ukraine, USA, and Poland. The object of the study was information on registered drugs in Ukraine, the USA, and Poland. The applied methods of study include generalization, systematization, and comparative analysis.
The range of medicinal films presented in the pharmaceutical markets of Ukraine, the USA, and Poland is analyzed. It is found that as of November 2019, there were 24 medicinal films registered in Ukraine, 70 medicinal films in Poland, and 104 medicinal films in the USA. Medicines in the form of transdermal therapeutic systems or patches have been registered in the pharmaceutical market of Ukraine. No buccal and oral drug films have been registered. In the Ukrainian market medicinal films are exclusively represented by foreign manufacturers from Germany (65%), Ireland (10%), Belgium (10%), Greece (5%), United Kingdom (5%), and the United States (5%).
The largest range of medical films is presented in the USA: 89.2% transdermal films, 7.8% – buccal films, 2.9% – oral films. In the Polish market, transdermal therapeutic systems also account for the largest share, with only 3% of the range being buccal films. In this study, we found that the active substances such as fentanyl, buprenorphine, estradiol, nicotine, nitroglycerin, rivastigmine, rotigotine, testosterone, scopolamine, oxybutynin, and others are most often introduced into drug films. It is found that in the US market the share of domestic manufacturers of medical films is 55.79%. Ukrainian pharmaceutical manufacturers do not offer medical films, which is a prerequisite for the development of those domestic dosage forms.
Thermodynamic properties of L-menthol in crystalline and gaseous states
Authors: Blokhin A. V. , Yurkshtovich Ya. N. 
Published: March 2020

Objectives. Menthol causes a cooling sensation and reduces the nerve activity when it is applied locally, ingested, or inhaled. This feature explains its extensive use as both an aromatizer and a flavoring agent in food manufacturing, tobacco industry, cosmetics production, as well as a mild anesthetic and antiseptic in dentistry. This work aimed to perform a comprehensive thermodynamic study of L-menthol in both crystalline and gaseous states.Methods. To determine the combustion energy of L-menthol in the crystalline state, combustion bomb calorimetry was used. The temperature dependence of L-menthol’s heat capacity in the range of 5–370 K and the melting (fusion) parameters were determined using adiabatic calorimetry. Quantum chemical calculations were performed on a standalone virtual machine in the Google Cloud Platform using an eight-core Intel Xeon Scalable Processor (Skylake) with a 2.0 GHz (up to 2.7 GHz at peak load) clock frequency and 8 GB RAM.Results. The energy and enthalpy of L-menthol combustion in the crystalline state were determined, and the standard enthalpy of L-menthol formation in the gaseous state was calculated using the standard enthalpy of sublimation. The standard thermodynamic functions (reduced enthalpy, entropy, and reduced Gibbs energy) of L-menthol in both crystalline and liquid states were obtained based on the smoothed values of heat capacity and melting parameters. The group of isodesmic reactions for the ab initio calculation of the enthalpy of formation for gaseous L-menthol was substantiated. Electronic energy and frequencies of normal modes of the molecules involved in these reactions were calculated using the Gaussian 4 composite quantum chemical method. Further, the sublimation enthalpy of L-menthol was calculated using the extended Politzer equation according to the electrostatic potential model.Conclusions. The first comprehensive thermodynamic study of L-menthol in various states of aggregation was performed, and the values calculated using semiempirical methods were consistent with the experimental values within error limits, which confirms the reliability of the results.
Сationic liposomes as delivery systems for nucleic acids
Authors: Mikheev A. A. , Shmendel E. V. , Zhestovskaya E. S. , Nazarov G. V. , Maslov M. A. 
Published: March 2020

Objectives. Gene therapy is based on the introduction of genetic material into cells, tissues, or organs for the treatment of hereditary or acquired diseases. A key factor in the success of gene therapy is the development of delivery systems that can efficiently transfer genetic material to the place of their therapeutic action without causing any associated side effects. Over the past 10 years, significant effort has been directed toward creating more efficient and biocompatible vectors capable of transferring nucleic acids (NAs) into cells without inducing an immune response. Cationic liposomes are among the most versatile tools for delivering NAs into cells; however, the use of liposomes for gene therapy is limited by their low specificity. This is due to the presence of various biological barriers to the complex of liposomes with NA, including instability in biological fluids, interaction with serum proteins, plasma and nuclear membranes, and endosomal degradation. This review summarizes the results of research in recent years on the development of cationic liposomes that are effective in vitro and in vivo. Particular attention is paid to the individual structural elements of cationic liposomes that determine the transfection efficiency and cytotoxicity. The purpose of this review was to provide a theoretical justification of the most promising choice of cationic liposomes for the delivery of NAs into eukaryotic cells and study the effect of the composition of cationic lipids (CLs) on the transfection efficiency in vitro.Results. As a result of the analysis of the related literature, it can be argued that one of the most promising delivery systems of NAs is CL based on cholesterol and spermine with the addition of a helper lipid DOPE. In addition, it was found that varying the composition of cationic liposomes, the ratio of CL to NA, or the size and zeta potential of liposomes has a significant effect on the transfection efficiency.Conclusions. Further studies in this direction should include optimization of the conditions for obtaining cationic liposomes, taking into account the physicochemical properties and established laws. It is necessary to identify mechanisms that increase the efficiency of NA delivery in vitro by searching for optimal structures of cationic liposomes, determining the ratio of lipoplex components, and studying the delivery efficiency and properties of multicomponent liposomes.
Application of the mercury porosimetry method in the analysis of sorption materials
Authors: Kostoev R. K. , Tochiev D. S. , Nilkho E. I. , Sultigova Z. N. , Archakova R. D. , Temirkhanov B. A. , Uzhakhova L. Ya. 
Published: March 2020

Objectives. This study aims to establish the available porosity of a sorbent based on carbonized rice husk and investigate its sorption properties for oil and oil products.Methods. A rice-husk-based sorbent carbonized at 400°С for 30 min was selected as the subject. The porosity of this sorbent is analyzed with the help of mercury porosimeters, the Pascal 140 EVO and Pascal 240 EVO. The sorption properties of the sorbent are also studied when cleaning water containing oil and oil products.Results. The test sample is a bulk porous material with a pore volume of 0.015 cm/g; porosity higher than 15% was found, and the pore size distribution is shown. Studies were conducted on the sorption of oil and oil products as well as the possibility of using the aforementioned sorbent as a filtering material in the purification of water containing oil products. We investigated the sorption processes under dynamic and static conditions. The methodology for measuring the porous structure of solid materials on the mercury porosimeter, Pascal 140 EVO, was examined. The texture characteristics of the sorbent’s porous structure were determined, which is primarily the total volume of pores, the values of the specific surface area, and the volume of the microspores and mesopores.Conclusions. The materials studied can be used as sorbents with a developed porous structure for purification of water with dissolved and emulsified petroleum products.