bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bridging the Policy Gap: A Critical Autoethnography of Asylum Accompaniment
Authors: Heffernan Amanda , Hudgins Audrey 
Published: December 2024

Executive Summary Unlike refugees, most asylum-seekers receive scant attention from US government and non-profit agencies. A loose network of individuals and organizations aims to bridge this gap in policy and services through the practice of asylum accompaniment. This article, by two scholar-activists with a combined 10 years of experience accompanying asylum-seekers, aims to: • Explore the praxis of asylum accompaniment via critical autoethnography, using our accompaniment narratives to illuminate the dynamics of accompaniment relationships, including the profound mutual benefits of this type of engagement and the complexities of social and political power, privilege, and access • Propose policy solutions that emerge from critical reflection on our experiences, including increased support for accompaniment networks • Offer a practical tool, The ABCs of Asylum Accompaniment, as a resource for informed accompaniment of asylum-seekers
CNVizard—a lightweight streamlit application for an interactive analysis of copy number variants
Authors: Krause Jeremias , Classen Carlos , Dey Daniela , Lausberg Eva , Kessler Luise , Eggermann Thomas , Kurth Ingo , Begemann Matthias , Kraft Florian 
Published: December 2024

Abstract
Background
Methods to call, analyze and visualize copy number variations (CNVs) from massive parallel sequencing data have been widely adopted in clinical practice and genetic research. To enable a streamlined analysis of CNV data, comprehensive annotations and good visualizations are indispensable. The ability to detect single exon CNVs is another important feature for genetic testing. Nonetheless, most available open-source tools come with limitations in at least one of these areas. One additional drawback is that available tools deliver data in an unstructured and static format which requires subsequent visualization and formatting efforts.

Results
Here we present CNVizard, an interactive Streamlit app allowing a comprehensive visualization of CNVkit data. Furthermore, combining CNVizard with the CNVand pipeline allows the annotation and visualization of CNV or SV VCF files from any CNV caller.

Conclusion
CNVizard, in combination with CNVand, enables the comprehensive and streamlined analysis of short- and long-read sequencing data and provide an intuitive webapp-like experience enabling an interactive visualization of CNV data.
Navigating menstrual stigma and norms: a qualitative study on young people’s menstrual experiences and strategies for improving menstrual health
Authors: Åkerman Eva , Wängborg Anna , Persson Maria , Sörensdotter Renita , Klingberg-Allvin Marie 
Published: December 2024

Abstract
Background
Menstrual health is a recognised important public health issue and is essential for the realisation of gender equality and the achievement of Sustainable Development Goals. This study aimed to explore the menstrual health experiences of young people in Sweden and how the menstrual cycle affects their health and lives. The study also aimed to identify the facilitators and barriers to achieving menstrual health.

Methods
We conducted a qualitative study in Sweden. Sixteen young people aged 18–28 who have experienced the menstrual cycle participated in individual interviews. Purposeful sampling combined with snowball sampling was applied to recruit the participants. The data were analysed using reflexive thematic analysis.

Results
Participants viewed menstruation as a sign of having a healthy and functioning body. Menstruation was linked to becoming a woman and fostered a sense of community and sisterhood, which was viewed as positive among cis women. Further, the results showed that physical and emotional symptoms related to the menstrual cycle limited the participants’ everyday lives and social relationships and had a negative effect on their sexual and mental health. While managing their emotional discomfort and other menstrual complaints, they also had to deal with the public stigma and norms about menstruation contributing to shame and worries. Barriers to menstrual health included stigma and norms related to menstruation, which led to the adoption of expected behaviours, such as avoiding participation in social activities. The normalisation of menstrual complaints also contributed to delays in seeking healthcare, despite having symptoms that had a negative effect on their health. An important factor promoting menstrual health and quality of life is access to prompt treatment to mitigate and decrease symptoms that limit everyday life.

Conclusions
The results indicate that menstrual stigma and related norms create challenging situations limiting menstruating people’s everyday lives and reluctance to seek healthcare despite needing to. To promote the menstrual health of menstruating young people in Sweden, organised and systematic screening of menstrual cycle-related symptoms should be provided within student health services at schools and universities, and primary healthcare. Policymakers should consider integrating stigma-reducing efforts into public health interventions to improve general awareness and promote gender equality.
Aspergillus foetidus as a potent producer for β-galactosidase utilizing lemon peels and coffee waste powder: production optimization, purification, kinetic and thermodynamic characterization
Authors: Wahab Walaa A. Abdel , Saleh Shireen A. A. , Elzairy Nermeen H. , Ahmed Samia A. , Zaki Eman R. , Salama Walaa H. , Mostafa Faten A. 
Published: December 2024

Abstract
Background
The main obstacle facing the utilization of microbial enzymes in industrial applications is the high cost of production substrates. As a result of the mentioned different wastes (coffee powder waste, dates nawah powder, molokhia stems, pea peels, lemon peels, and corn cobs) were investigated as low-cost nutritional substrates for the production of microbial β-galactosidase in this study. The purification of the enzyme and its kinetic and thermodynamics were investigated.

Results
β-galactosidase was effectively produced by Aspergillus foetidus utilizing lemon peels and coffee powder waste by solid-state fermentation technique. The production yield was improved through Plackett-Burman Design declaring the significant effect of lemon peels and coffee waste powder, and beef extract quantities on A. foetidus β-galactosidase production. Followed by Central Composite Design investigating each factor with five levels resulting in 37363.1 U.ml− 1 production. The enzyme was fully purified by gel filtration technique through Sephadex G-150 giving one band with a molecular weight 40 KDa on SDS-PAGE gel. The maximal β-galactosidase activity was obtained at 50 °C with 0.4% ONPG. Cu2+, Fe2+, and Hg2+ showed severe inhibitory effect on pure enzyme activity. Energy required for enzyme activation (Ea) and denaturation (Ed) were determined to be 17.40, and 43.86 KJ.mol− 1, respectively. Parameters reflecting β-galactosidase thermal stability at 40, 45, and 50 °C as T1/2 and D-values values were determined to be 283.92, 209.43, and 168.56 min, and 943.34, 695.84, and 560.06 min, respectively.
A prospective, multicentre study evaluating safety and efficacy of a fixed dose combination of Remogliflozin etabonate, Vildagliptin, and Metformin in Indian patients with type 2 diabetes mellitus (Triad-RMV)
Authors: Agarwal Prabhat K , Bhushan Divendu , Bhate Amit , Naik Sunil , Adwani Shailesh , Kushwaha J S , Bhushan Sumit , Mane Abhishek , Gadkari Rujuta , Choudhari Sanjay , Patil Saiprasad , Barkate Hanmant 
Published: December 2024

Abstract
Aims
The ICMR INDIAB-17 study revealed a diabetes prevalence of 11.4% in India, emphasizing the need for effective treatment for glycemic control. A Phase IV study was conducted to evaluate the safety and efficacy of a Fixed Dose Combination (FDC) of Remogliflozin, Metformin and Vildagliptin (RMV) in Type 2 Diabetes Mellitus (T2DM) patients uncontrolled on Metformin plus SGLT2 inhibitor or Metformin plus DPP4 inhibitor dual therapy.

Methods
A total of 215 patients (mean age: 46.4 years; 64% male, 36% female) were enrolled across multiple centers in India. The study population included patients with a baseline HbA1c ≥ 8% at the time of screening. The primary objective was to assess safety based on treatment-emergent adverse events (TEAEs), while the secondary. aim was to evaluate effectiveness in terms of glycemic (HbA1c, fasting plasma glucose, postprandial glucose) and extra-glycemic measures (renal and lipid parameters). Statistical analysis was conducted using paired t-tests and the Wilcoxon signed-rank test for within-group comparisons, and the Bonferroni correction was applied to adjust for multiple comparisons. Effectiveness was evaluated at baseline, week 12, and week 24.

Results
The study demonstrated statistically significant reductions in mean HbA1c levels from baseline to both week 12 and week 24 (p < 0.00001). At 24, weeks, 45.1% of patients achieved target HbA1c levels of ≤ 7%. Significant reduction was also observed in fasting plasma glucose (FPG) and postprandial glucose (PPG) levels. Renal parameters remained stable or improved, and lipid profile parameters, including LDL-C and triglycerides, showed favorable changes. Adverse events of special interest, including hypoglycemia and urinary tract infections, were reported in 4.7% of patients, with no serious adverse event recorded.

Conclusions
The twice daily triple FDC of RMV was well tolerated, safe and effective in patients with Type 2 Diabetes Mellitus uncontrolled on dual drug therapy of Metformin plus SGLT2i or Metformin plus DPP4i. The treatment led to significant improvements in glycemic control and other metabolic parameters over 24 weeks, without compromising renal function or causing serious adverse events.

Trial registration
CTRI, CTRI/2022/05/042581. Registered 17 May 2022, https//ctri.nic.in/Clinicaltrials/rmaindet.php? trialid=68,757&EncHid=36127.16500&modid=1&compid=19.
A study of stressful life events in patients with first-episode acute coronary syndrome (ACS)—a hospital-based case–control study
Authors: Kousar Muntaqueem Ul , Parveen Shaheena , Maqbool Masood , Rather Yasir Hassan , Bhat Fazle Roub , Jan Neelofar , Rasool Ubaid 
Published: December 2024

Abstract
Background
There is considerable evidence in the literature highlighting the impact of psychological factors on the development of coronary heart disease. In India, there's a rising incidence of traumatic life events alongside coronary heart disease, yet the connection between them remains relatively understudied. Therefore, this study aims to investigate stressful life events among patients experiencing their first episode of acute coronary syndrome (ACS) and compare this with controls.

Results
The mean number of stressful life events (SLEs) observed was 5.07 ± 2.04 in cases and 4.35 ± 1.88 in controls, with a p-value of < 0.05. Cases had a significantly higher prevalence of medical and psychiatric morbidity than controls, with rates of 89.3% compared to 69.6% for medical issues, and 56.7% versus 24.0% for psychiatric conditions, respectively. Univariate analyses revealed a significant difference between cases and controls in the types of stressors experienced, with cases showing higher odds ratios (OR) for specific events such as Fire or Explosion (OR = 4.5), Transportation accident (OR = 3.4), and Captivity (OR = 2.3). Additionally, bivariate analyses indicated that presence of a comorbid medical illness had an OR of 5.95. At the same time, specific life events like Exposure to fire or explosion (OR = 3.35) and Transportation accidents (OR = 3.08) were more likely to occur in cases. Overall, there were significant differences in the prevalence and pattern of various types of SLEs between cases and controls.

Conclusion
The higher number of SLEs observed in cases compared to controls underscores their potential role in cardiac risk. While transportation accidents and fires/explosions demonstrated robust associations with ACS, the variable significance across different types of SLEs suggests a complex relationship between stressor type and cardiac outcomes. These findings highlight the need for prospective studies with larger sample sizes and further research to ascertain and quantify the role of stressful events and the risk of a cardiac event.
Antioxidant activity and resistance traits of Aesculus species against Cameraria ohridella Deschka & Dimić infestation in the Ukraine steppe
Authors: Shupranova Larysa , Holoborodko Kyrylo , Zhukov Oleksandr , Shulman Maria , Loza Iryna , Seliutina Oksana , Ivanko Iryna 
Published: December 2024

The study aimed to assess the enzymatic antioxidant system for determining the species-specific response of Aesculus species different in tolerance to C. ohridella attacks. Antioxidant activity of non-infested and infested leaves in six species of the genus Aesculus was investigated on 15-year-old representatives growing in Dnipro city (Steppe zone, Ukraine). The leaves of Aesculus both healthy and mined by C. ohridella were sampled within Dnipro city in 2023. Activity of benzidine and guaiacol peroxidase (BPx, GPx), catalase (CAT), and content of soluble proteins (SP) were determined. The isoenzyme composition of BPx was determined by isoelectric focusing (IEF). Statistical differences between the species were corroborated via ANOVA using Statistica software. High constitutive levels of BPx, GPx activities and soluble protein concentrations were detected in the leaves of Aesculus parviflora; this species was highly resistant to the leaf miner infestation compared to unresistant Ae. hippocastanum and moderately resistant species. Different adaptative ways of Aesculus species to C. ohridella influence were shown to occur due to the diverse functional role of oxidative enzymes. In A. glabra, catalase was activated; induction of this enzyme occurs only at high ROS concentrations. BPX stimulation found in A. hippocastanum and A. flava could indicate the participation of this enzyme in hydrogen peroxide neutralization and synthesis of phenolic compounds. Increased GPx activity (in A. pavia) occurred mainly (except for the disposal of H2O2) to strengthen the cell wall; it enhanced the resistance response against the influence of the horse-chestnut leaf miner. Under the influence of the oligophagous insect, only quantitative changes in IEF profiles of isoperoxidase were recorded specifically depended on the species of Aesculus. This output may be beneficial for application of Aesculus plants (A. parviflora, A. × carnea, A. flava) highly resistant to stress in urban green plantings. This study showed that the antioxidant status of leaves in the genus Aesculus can be a reliable indicator of the plant tolerance to C. ohridella attacks.
Nurses’ knowledge of paediatric palliative care in a children's hospital
Authors: Pérez-Pérez José Tubal , Vázquez-Sánchez Juan Manuel , Martín-Romero Irene , de Noriega Iñigo 
Published: December 2024

Background: Effective training of health professionals is essential to end-of-life care. Aims: To explore the level of knowledge on paediatric palliative care (PPC) of nurses in a children's monographic hospital. Methods: Cross-sectional observational analytical study. A sample of 53 nurses were selected. The translated and validated Spanish version of the Palliative Care Quiz for Nurses was used. Findings: Statistically significant differences (Mann-Whitney U; p=0.0346) were found between the knowledge of nurses in non-PPC-specific wards and nurses working in PPC, with the latter having a higher level of training in PPC (Chi-square; p=0.042). Conclusion: Professional experience with children with palliative needs and training seems to be related to increased knowledge of palliative care.
Direct detection and classification of E. coli and fecal streptococci using an optical water droplet method and convolutional neural networks
Authors: Chia Lizette Nange , Talla Mbé Jimmi Hervé , Tatietse Thomas Tamo 
Published: December 2024

Detecting harmful bacteria in drinking water is a significant concern for public health. Indicator bacteria like E. coli and fecal streptococci serve as markers for fecal contamination of water [Environmental and Pollution Science (2019), pp. 191]. Several detection methods of these markers require costly equipment, and specialized laboratories and technicians, and are time-consuming, resulting in labor-intensive processes [J. Phys. Conf. Ser. 995, 012065 (2018)1742-658810.1088/1742-6596/995/1/012065]. This paper proposes an optimal method that combines an optical water droplet method and convolutional neural networks (CNNs) to provide an accurate and cost- and time-effective approach to directly detect and classify E. coli and fecal streptococci in water. The system captures images of indicator bacteria and then classifies them. We obtain a classification accuracy of up to 0.89 and a loss of 0.13. This work constitutes a step toward an integrated, real-time, and automatic optical-based detection system for water-borne pathogenic agents.
SOI-based parallel-ring microresonator for simultaneous sensing of refractive index and temperature
Authors: Zheng Shengmei , Jiang Xiaowei , Jiang Dafei 
Published: December 2024

In this paper, a new structure of microring
resonator that is composed of
two rings arranged in parallel coupling with two straight waveguides,
to our knowledge. is proposed. The rings are of different widths;
therefore the resonance wavelength shift is different with varying
surroundings. By measuring the resonance wavelength shift of the two
rings respectively, reflective index (RI) and temperature can be
sensed simultaneously. Our results revealed that the RI sensitivities
are 141.54 nm/RIU and 73.85 nm/RIU, respectively, and
temperature sensitivities are 40 pm/K and 46.25 pm/K,
respectively. By constructing a characteristic matrix, it is
demonstrated that the simultaneous measurement of RI and temperature
can be achieved. The simulation results show the error in measuring
refractive index is within the range from −1.11×10−4 to 2.19×10−4, and error in measuring the
temperature is within the range from −0.69K to 0.59 K. Sensitivity of the
device to analyst thickness is also investigated, and the results
reveal first sharp, and then saturated, redshift of the resonance
wavelength with increasing analyst thickness. The sensor has many
advantages, such as small footprint, simple structure, and easy
fabrication, which make it an ideal sensor to be used in
environmental, biological, and medical fields.
Structural parameter optimization of a fused all-fiber probe for light manipulation and multi-particle capture
Authors: Zhang Shuaishuai , Chen Yuxin , Bi Shubo , Cui Bolun , Wang Chi 
Published: December 2024

We propose and experimentally demonstrate an economical optical tweezers probe based on the fusion of several commercial optical fibers. By optimizing the structural parameters of the probe, non-contact active capture and manipulation of single or multiple biological particles were achieved. First, the probe structural parameter range was analyzed theoretically, and the theory was cross-verified by the finite element method. Second, the influence of the probe structure and length parameters on the laser focusing performance and particle capture ability was studied, and the optimal structural parameters of the probe in particle capture were determined. The measured capture distance exceeded 50 µm, and the movement velocity of the particle during manipulation was measured. Finally, the capture performance before and after parameter optimization was compared with the dynamic effect of the particles, and the generation mechanism of multiple light traps and the mechanical properties of multi-particles during multi-particle capture were studied. The results indicate that this probe is expected to be used in biological or chemical micromanipulation research.
Call for papers 2025: UNISA’s Hybrid International Conference On TVET (ICTVET) 2024. Volume 8, Issue 2. Special issue.
Authors: Robertson Catherine 
Published: December 2024

Due date for full papers: 31 January 2025.
Title of special issue: Advancing TVET for the Digitalised World, Youth Skilling, Employability and Sustainable Development
Themes for categorising papers: The submitted papers will be organised according to the following streams, but are not limited to the following:
Steering Global Disruptions• Climate change• Digitalisation• Fourth Industrial Revolution (4IR)• Learning Management Systems• Demographic change• Migration• Energy Security and Transition
Inclusion in Education (2024 marks 30 years since adoption of Salamanca Statement)• Re-orientating current TVET policies for inclusivity• Adapting teaching methods to accommodate vulnerable groups of learners• Training and support of TVET teaching staff/trainers to enable them to accommodate the diverse needs of learners
Multi-stakeholder Collaboration to Achieve Education Goals • Private sector engagement• Sustainable curriculum• Digital transformation collaborative efforts• Commitment of partnerships to advance common projects• Articulation• Funding opportunities• UNEVOC network and TVET contributions to sustain their membership
Strengthening Mechanisms• Quality Assurance• Leadership and accountability• Effective governance• Assessments, etc• Pathways for employment,• Skills for business entrepreneurship
TVET Research and Knowledge Base• Research studies and research in TVET• Digital transformation of TVET colleges
Conference presenters are invited to submit an article for a special issue of the Journal of Vocational, Adult and Continuing Education and Training (JOVACET) to be published in 2025. JOVACET is an accredited publication with the Department of Higher Education and Training and also publishes on the platform of sciELO.
Articles should be topical with regard to current debates/discourses and recent research in the TVET, adult, and continuing education and training domains. Submissions should be of a high quality and follow academic research/writing conventions of journal articles in the social sciences.
Specifications can be found on the JOVACET website (www.jovacet.ac.za) or obtained from Dr Catherine Robertson at cathy@tcrobertson.co.za.
Articles should comprise a maximum of 8000 words, which include the abstract of approximately 200 words and a list of references in the referencing style as specified on the website, and be submitted in MS Word format via the journal website at www.jovacet.ac.za or emailed to Dr Catherine Robertson at cathy@tcrobertson.co.za. Kindly follow the style guide which is provided on the website.
We look forward to receiving your submissions!
Due date for full papers: 31 January 2025.
Editor-in-Chief, JOVACET: Prof Joy Papier, University of the Western CapeManaging Editor, JOVACET: Dr Catherine Robertson, University of the Western CapeGuest Editors: Special Issue (UNISA): Prof M. Van Wyk; Prof M. Maphalala; Prof S. Khumalo
The Special Issue is scheduled for publication on 31 July 2025.