bluuebunny/crossref_metadata_2025_split huggingface dataset:
The psychological effects of systemic lupus erythematosus: the imitator of aging
Authors: Özsungur Fahri 
Published: January 2020

Objectives: To assess the psychological effects of systemic lupus erythematosus (SLE), including perception of aging, in a cohort of participants who were either diagnosed with SLE or had an affected family member. Methods: Over a period of 1 year, we conducted once-monthly face-to-face interviews with 12 participants. The participants were from 4 related families and include 7 females and 5 males. Three participants had a confirmed diagnosis of SLE. Spouses were also included in this study to assess transitivity of the psychological signs of SLE. Responses to structured interview questions were analyzed to assess the perception of aging. Results: The major complaints in participants diagnosed with SLE were pain and psychological stress. Nephrotic syndrome, urinary tract infection, weight disorders and increased need for psychosocial support were common in the participants’ medical history. Qualitative analysis of questionnaires completed by participants with SLE revealed a correlation of “feeling old” with the non-resolution of health complaints. Family members who did not have SLE also reported “feeling old”. Complaints of stress, anxiety, nervousness and lack of enjoyment of life were common in those who were diagnosed with SLE, as well as those who were not. All spouses reported experiencing digestive disorders, hemorrhoids as well as various phobias, regardless of whether their partners had a confirmed SLE diagnosis. Conclusions: In this study, we found that participants with SLE or those who had a close family member with SLE displayed psychological signs of aging. All participants had a predisposition to anxiety, while spouses developed various phobias. Statement of novelty: We show that individuals with SLE and close family members have an increased self-perception of aging.
Estudo sobre a influência da espessura e glandularidade da mama na dose glandular média em exames de tomossíntese
Authors: Engler Camila , Attie Márcia Regina Pereira , Reis Lucas Paixão , Nogueira Maria do Socorro 
Published: January 2020

A dose glandular média (DGM) é a grandeza dosimétrica utilizada para estimar a dose de radiação à qual uma paciente é exposta ao realizar um exame de mamografia. Este estudo tem como objetivo verificar a relação entre espessura da mama comprimida (EMC) e a densidade volumétrica da mama (DVM) com a DGM, assim como a relação da EMC e idade da paciente com a DVM. As imagens de tomossíntese mamária de 660 pacientes foram analisadas usando o software Volpara. A partir dessa análise, obteve-se a DVM e a DGM. A idade do paciente e EMC foram obtidas do cabeçalho DICOM das imagens. Utilizando o software estatístico SPSS, foram realizados testes de correlação entre a EMC e DVM com a DGM e entre a EMC e idade da paciente com a DVM. Para as correlações entre DVM e DGM, a grandeza EMC foi fixada de 10 em 10 mm. As correlações foram analisadas através dos coeficientes de correlação (r). Na relação entre DGM e EMC foi obtido r = 0,696. Para a relação DGM e DVM, a melhor correlação foi encontrada na faixa de 60 < EMC < 70 com r = 0,616. As correlações entre idade da paciente e EMC com DVM apresentaram r = -0,432 e r = -0,338, respectivamente. Os resultados mostram que a EMC é o fator mais relacionado ao aumento da DGM enquanto que a DVM é ligeiramente mais afetada pela idade da paciente do que pela EMC.
Morrey estimates for a class of elliptic equations with drift term
Authors: Cirmi G. R. , D’Asero S. , Leonardi S. 
Published: January 2020

Abstract
We consider the following boundary value problem

$$\begin{array}{}
\displaystyle
\begin{cases}
- {\rm div}{[M(x)\nabla u - E(x) u]} =f(x) & \text{in}~~ {\it\Omega} \\
u =0 & \text{on}~~
\partial{\it\Omega},
\end{cases}
\end{array}$$
where Ω is a bounded open subset of ℝN, with N > 2, M : Ω → ℝN2 is a symmetric matrix, E(x) and f(x) are respectively a vector field and function both belonging to suitable Morrey spaces and we study the corresponding regularity of u and D u.
The “olfactory fingerprint”: can diagnostics be improved by combining canine and digital noses?
Authors: Lippi Giuseppe , Heaney Liam M. 
Published: January 2020

Abstract
A sniffer (detecting) dog is conventionally defined as an animal trained to use its olfactory perceptions for detecting a vast array of substances, mostly volatile organic compounds (VOCs), including those exceptionally or exclusively generated in humans bearing specific pathologies. Such an extraordinary sniffing performance translates into the capability of detecting compounds close to the femtomolar level, with performance comparable to that of current mass spectrometry-based laboratory applications. Not only can dogs accurately detect “abnormal volatilomes” reflecting something wrong happening to their owners, but they can also perceive visual, vocal and behavioral signals, which altogether would contribute to raise their alertness. Although it seems reasonable to conclude that sniffer dogs could never be considered absolutely “diagnostic” for a given disorder, several lines of evidence attest that they may serve as efficient screening aids for many pathological conditions affecting their human companions. Favorable results have been obtained in trials on cancers, diabetes, seizures, narcolepsy and migraine, whilst interesting evidence is also emerging on the capability of early and accurately identifying patients with infectious diseases. This would lead the way to proposing an “olfactory fingerprint” loop, where evidence that dogs can identify the presence of human pathologies provides implicit proof of the existence of disease-specific volatilomes, which can be studied for developing laboratory techniques. Contextually, the evidence that specific pathologies are associated with abnormal VOC generation may serve as reliable basis for training dogs to detect these compounds, even (or especially) in patients at an asymptomatic phase.
Breaking out of the Regulatory Delusion. The Ban to Surrogacy and the Foundations of European Constitutionalism
Authors: Calderai Valentina 
Published: January 2020

Abstract
The transnational market of reproductive services puts a strain on western European States that refuse to acknowledge surrogacy contracts on public policy grounds. The cases decided so far rise three questions. First, under what circumstances foreign surrogacy judgements should be recognised? Second, what would be the constitutional repercussions of the recognition of these judgements? Third, how would it be like a legislation at once effective and respectful of fundamental rights of all parties involved? This Article analyses these questions and how they relate to each other. Based on a transaction-cost economic framework an argument is made that neither top-down, nor market-based regulatory solutions overcome the constitutional arguments that uphold the ban to surrogacy. An alternative approach to legal reform is considered, grounded on IPL and substantive domestic measures.
Changing perspectives on /s/ and gender over time in Glasgow
Authors: Stuart-Smith Jane 
Published: January 2020

AbstractThis paper considers the relative influence on sociophonetic interpretation of /s/ using “static” and “dynamic” acoustic analysis, wheredynamicrefers to the use of measures which capture the time-varying nature of segmental acoustics, andstaticto measures which are taken at a single point, or from an average across the sound (Watson and Harrington 1999, Docherty et al. 2015). Static and dynamic Discrete Cosine Transformation (DCT) analyses of spectral Centre of Gravity (CoG) and spectral Slope measures/trajectories were carried out on gendered productions of /s/ and /ʃ/ for a real- and apparent-time 32 speaker sample of spontaneous Glasgow dialect. Results of static CoG measures, reflecting place of articulation, indicate a reduction of gender differentation over time, such that girls born most recently revert to older vernacular (lower frequency) norms. Adding static spectral Slope, reflecting articulatory constriction, shows a change in gendered differentiation, whereby boys born most recently show a gestural shift. The DCT analysis both confirms the static results and also reveals that dynamic characteristics of both sibilants carry key additional prosodic, linguistic and social information for this community. Our results reflect for the first time the usefulness of changing analytical perspectives on /s/, both in terms of acoustic representation (static and dynamic), but also by considering /s/ alongside its partner sibilant /ʃ/ within the context of shifts in the construction of social gender over time.
Recognising regional varieties of Danish
Authors: Tøndering John , Pharao Nicolai 
Published: January 2020

Abstract
Regional varieties of Danish are distinguished mainly by prosodic cues, in particular the tonal stress group pattern. We test the hypothesis that prosody is a strong cue for identifying the regional background of speakers. This hypothesis was studied using an online survey in which listeners were asked to identify the origin of speakers based on examples from four different regional varieties of Danish. Listeners identified speaker origin on the basis of both natural, monotonised and delexicalised speech samples. The results show that although most listeners are able to identify the four regional varieties correctly, it is more reasonable to say that Danes categorise the regional varieties into broader categories of Western and Eastern Danish. Prosody clearly plays an important role in the identification of the varieties, but reliable identification is difficult based on prosody alone.
Wideband tunable perfect absorption of graphene plasmons via attenuated total reflection in Otto prism configuration
Authors: Nong Jinpeng , Tang Linlong , Lan Guilian , Luo Peng , Guo Caicheng , Yi Juemin , Wei Wei 
Published: January 2020

Abstract
A strategy is proposed to achieve wideband tunable perfect plasmonic absorption in graphene nanoribbons by employing attenuated total refraction (ATR) in Otto prism configuration. In this configuration, the Otto prism with a deep-subwavelength dielectric spacer is used to generate tunneling evanescent waves to excite localized plasmons in graphene nanoribbons. The influence of the configuration parameters on the absorption spectra of graphene plasmons is studied systematically, and the key finding is that perfect absorption can be achieved by actively controlling the incident angle of light under ATR conditions, which provides an effective degree of freedom to tune the absorption properties of graphene plasmons. Based on this result, it is further demonstrated that by simultaneously tuning the incident angle and the graphene Fermi energy, the tunable absorption waveband can be significantly enlarged, which is about 3 times wider than the conventional cavity-enhanced configuration. Our proposed strategy to achieve wideband, tunable graphene plasmons could be useful in various infrared plasmonic devices.
Lanthanide orthothiophosphates revisited: single-crystal X-ray, Raman, and DFT studies of TmPS4 and YbPS4
Authors: Scholz Tanja , Pielnhofer Florian , Eger Roland , Lotsch Bettina V. 
Published: January 2020

Abstract
The crystal structures of the lanthanide orthothiophosphates LnPS4 (Ln=lanthanide) have been extensively investigated in the past. Up to now, however, single crystals of two members of this series – TmPS4 and YbPS4 – have not been available. Here, we report a modified synthesis protocol for TmPS4 and YbPS4 yielding single crystals suitable for X-ray diffraction. Both compounds crystallize in the tetragonal space group I41/acd (no. 142) with 16 formula units per unit cell and adopt the SmPS4 parent structure, like most reported lanthanide orthothiophosphates. The structures contain isolated [PS4]3− tetrahedra and two crystallographically independent Ln
3+ cations, which form trigonal-dodecahedral [LnS8]13− polyhedra. The lattice parameters for TmPS4 are a = 10.598(2), c = 18.877(4) Å with V = 2120.2(6) Å3, and for YbPS4
a = 10.577(2), c = 18.827(4) Å with V = 2106.2(7) Å3. The DFT-calculated electronic band structures indicate semiconducting behavior and reveal indirect band gaps of 2.1–2.2 eV, consistent with the reddish brown color of YbPS4, but underestimating the band gap of pale-yellow TmPS4. The Raman spectra are dominated by [PS4]3− vibrations as confirmed by DFT-calculated phonon spectra. DTA measurements reveal remarkably high thermal stability compared to other known orthothiophosphate compounds.
Mítico Manet. Ideologías estéticas en los orígenes de la pintura moderna
Authors: Rojas Gil Cristóbal Javier 
Published: January 2020

Una vez más vuelve a sorprendernos la voluntad de especulación y problematización de Luis Puelles Romero, Profesor de Estética y Teoría de las Artes de la Universidad de Málaga, en esta nueva obra, editada por Abada. En Mítico Manet. Ideologías estéticas en los orígenes de la pintura moderna (2019) el esfuerzo intelectual del autor se centra en la figura de Édouard Manet, concretamente en el cuestionamiento de los valores estéticos responsables de consagrar al pintor como «inventor de lo moderno». Será a hombros de Baudelaire, Zola y Mallarmé desde donde el autor responda al interrogante acerca del posicionamiento de Manet como mito fundacional de la pintura moderna. Para hacerlo, Puelles focaliza su interés en tres ideas que serán estudiadas en cada una de los episodios secuenciales en los que se divide el libro: modernidad, originalidad y visualidad, respectivamente.
The role of postoperative adjuvant radiotherapy in local recurrence risk in medullary thyroid carcinoma
Authors: Kukulska Aleksandra , Krajewska Jolanta , Kolosza Zofia , Paliczka-Cieslik Ewa , Kropinska Aleksandra , Pawlaczek Agnieszka , Puch Zbigniew , Ficek Kornelia , Lisik Teresa , Sygula Dorota , Wygoda Zbigniew , Roskosz Jozef , Wydmanski Jerzy , Jarzab Barbara 
Published: January 2020

The value of postoperative radiotherapy in the treatment of medullary thyroid carcinoma (MTC) has not been unequivocally demonstrated. Therefore our study aimed to answer the question of whether adjuvant radiotherapy showed any impact on the risk of local recurrence and whether there were any differences in response to radiotherapy between hereditary and sporadic MTC.

Methods
A retrospective analysis involved 254 MTC patients, among them 73 patients with a hereditary disease. Two hundred and twenty-four patients, including 43 persons at a high risk of local relapse, underwent only initial surgery; 18 other patients were operated due to MTC recurrences, whereas the remaining 12 patients had cytoreductive procedure or were not amenable for surgery. Radiotherapy was carried out in 132 patients. One hundred and twenty patients underwent adjuvant radiotherapy, among them 102 patients after initial surgery. The median follow-up was 10 years (range 0.5–29 years).

Results
Local recurrence occurred in 107/254 patients, among them in 63 subjects after prior radiotherapy. The frequency of relapse showed significantly increasing trend toward higher MTC stages (P <0.001). More relapses occurred in patients with lymph node metastases present at MTC onset. Adjuvant radiotherapy was associated with a lower risk of nodal recurrence only in high-risk patients, particularly if lymph node metastases were present at MTC diagnosis. The differences between hereditary and sporadic subgroups were not significant.

Conclusions
Adjuvant radiotherapy has a limited importance in MTC treatment. It should be considered in high-risk MTC patients. The presence of RET mutation does not influence the response to radiation.
Increased prevalence of overweight and obesity in children with X-linked hypophosphatemia
Authors: Zhukouskaya Volha V , Rothenbuhler Anya , Colao Annamaria , Di Somma Carolina , Kamenický Peter , Trabado Séverine , Prié Dominique , Audrain Christelle , Barosi Anna , Kyheng Christèle , Lambert Anne-Sophie , Linglart Agnès 
Published: January 2020

Background/aim
X-linked hypophosphatemia (XLH) is a rare disease characterized by low phosphate levels. Scientific evidence points to a link between hypophosphatemia and obesity in general population. The aim of our longitudinal observational study was to investigate the prevalence of obesity and associated factors in a large cohort of children with XLH.

Patients/methods
We studied 172 XLH-children 5–20 years of age (113 girls/59 boys). Anthropometric parameters (weight, height, and BMI) were collected at birth and during follow-up at mean ages of 5.3, 8.2, 11.3, and 15.9 years (groups 1, 2, 3, and 4, respectively). In each group, subjects were classified based on International Obesity Taskforce (IOTF) cut off values of BMI for age and sex as overweight or obese (IOTF 25–30 or ≥30 kg/m2, respectively).

Results
In each age-group, almost 1/3 of XLH-patients were classified as overweight or obese (29.4, 28.7, 27.5, and 36.7% in groups 1, 2, 3, and 4, respectively). Children without a XLH-family history had higher BMI-IOTF at every point of follow-up, compared to those with positive XLH-family history. Similarly, higher BMI-IOTF was significantly associated with treatment duration (23.3 ± 4.4 vs 23.8 ± 3.8 vs 25.2 ± 4.5 kg/m2, for subjects with treatment duration of <5, 5–10 and >10 years, respectively, P for trend = 0.025). Multiple regression analysis confirmed an association of treatment duration and lack of XLH-family history with higher BMI-IOTF.

Conclusion
One out of three of XLH-children have phenotypically unfavourable metabolic profile expressed as increased prevalence of overweight or obesity in comparison to general population. Both the lack of XLH family history and the duration of treatment increase the risk of higher BMI-IOTF. BMI should be carefully monitored in children, and later in adults, with XLH.
Changes in adipose tissue lipolysis gene expression and insulin sensitivity after weight loss
Authors: Karczewska-Kupczewska Monika , Nikołajuk Agnieszka , Majewski Radosław , Filarski Remigiusz , Stefanowicz Magdalena , Matulewicz Natalia , Strączkowski Marek 
Published: January 2020

Objective
Insulin resistance is a major pathophysiological link between obesity and its metabolic complications. Weight loss (WL) is an effective tool to prevent obesity-related diseases; however, the mechanisms of an improvement in insulin sensitivity (IS) after weight-reducing interventions are not completely understood. The aim of the present study was to analyze the relationships between IS and adipose tissue (AT) expression of the genes involved in the regulation of lipolysis in obese subjects after WL.

Methods
Fifty-two obese subjects underwent weight-reducing dietary intervention program. The control group comprised 20 normal-weight subjects, examined at baseline only. Hyperinsulinemic-euglycemic clamp and s.c. AT biopsy with subsequent gene expression analysis were performed before and after the program.

Results
AT expression of genes encoding lipases (PNPLA2, LIPE and MGLL) and lipid-droplet proteins enhancing (ABHD5) and inhibiting lipolysis (PLIN1 and CIDEA) were decreased in obese individuals in comparison with normal-weight individuals. The group of 38 obese participants completed dietary intervention program and clamp studies, which resulted in a significant WL and an improvement in mean IS. However, in nine subjects from this group IS did not improve in response to WL. AT expression of PNPLA2, LIPE and PLIN1 increased only in the group without IS improvement.

Conclusions
Excessive lipolysis may prevent an improvement in IS during WL. The change in AT PNPLA2 and LIPE expression was a negative predictor of the change in IS after WL.
Association between dietary calcium intake and BMD in children and adolescents
Authors: Pan Kaiyu , Zhang Chengyue , Yao Xiaocong , Zhu Zhongxin 
Published: January 2020

Aim
Ensuring adequate calcium (Ca) intake during childhood and adolescence is critical to acquire good peak bone mass to prevent osteoporosis during older age. As one of the primary strategies to build and maintain healthy bones, we aimed to determine whether dietary Ca intake has an influence on bone mineral density (BMD) in children and adolescents.

Methods
We conducted a cross-sectional study composed of 10,092 individuals from the National Health and Nutrition Examination Survey (NHANES). Dietary Ca intake and total BMD were taken as independent and dependent variables, respectively. To evaluate the association between them, we conducted weighted multivariate linear regression models and smooth curve fittings.

Results
There was a significantly positive association between dietary Ca intake and total BMD. The strongest association was observed in 12–15 year old whites, 8–11 year old and 16–19 year old Mexican Americans, and 16–19 year old individuals from other race/ethnicity, in whom each quintile of Ca intake was increased. We also found that there were significant inflection points in females, blacks, and 12–15 year old adolescents group, which means that their total BMD would decrease when the dietary Ca intake was more than 2.6–2.8 g/d.

Conclusions
This cross-sectional study indicated that a considerable proportion of children and adolescents aged 8–19 years would attain greater total BMD if they increased their dietary Ca intake. However, higher dietary Ca intake (more than 2.6–2.8 g/d) is associated with lower total BMD in females, blacks, and 12–15 year old adolescents group.
Absence of a Faster-X Effect in Beetles (Tribolium, Coleoptera)
Authors: Whittle Carrie A , Kulkarni Arpita , Extavour Cassandra G 
Published: January 2020

Abstract
The faster-X effect, namely the rapid evolution of protein-coding genes on the X chromosome, has been widely reported in metazoans. However, the prevalence of this phenomenon across diverse systems and its potential causes remain largely unresolved. Analysis of sex-biased genes may elucidate its possible mechanisms: for example, in systems with X/Y males a more pronounced faster-X effect in male-biased genes than in female-biased or unbiased genes may suggest fixation of recessive beneficial mutations rather than genetic drift. Further, theory predicts that the faster-X effect should be promoted by X chromosome dosage compensation. Here, we asked whether we could detect a faster-X effect in genes of the beetle Tribolium castaneum (and T. freemani orthologs), which has X/Y sex-determination and heterogametic males. Our comparison of protein sequence divergence (dN/dS) on the X chromosome vs. autosomes indicated a rarely observed absence of a faster-X effect in this organism. Further, analyses of sex-biased gene expression revealed that the X chromosome was particularly highly enriched for ovary-biased genes, which evolved slowly. In addition, an evaluation of male X chromosome dosage compensation in the gonads and in non-gonadal somatic tissues indicated a striking lack of compensation in the testis. This under-expression in testis may limit fixation of recessive beneficial X-linked mutations in genes transcribed in these male sex organs. Taken together, these beetles provide an example of the absence of a faster-X effect on protein evolution in a metazoan, that may result from two plausible factors, strong constraint on abundant X-linked ovary-biased genes and a lack of gonadal dosage compensation.