bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of parametric and artificial neural network modeling approaches for total tree height prediction in cedar plantations
Authors: Karatepe Yasin , Diamantopoulou Maria J. , Özçelik Ramazan , Sürücü Zerrin 
Published: October 2020

Abstract
Background: Height-diameter relationships are of critical importance in tree and stand volume estimation. Stand description, site quality determination and proper forest management decisions originate from reliable stem height predictions. Methods: In the context of this work, the prediction ability of the developed height-diameter models was investigated for cedar (Cedrus libani A. Rich.) plantations in Western Mediterranean Region of Turkey. Towards this direction, parametric modeling methods such as fixed-effects, generalized models, and mixed-effects were evaluated. Furthermore, in an effort to come up with the construction of more reliable stem-height prediction models, artificial neural networks were employed using two different modeling algorithms: the Levenberg-Marquardt and the resilient back-propagation. Results: Taking into account the prediction behavior of each respective modelling strategy while using a new validation data set, the mixed-effects model with calibration using 3 trees for each plot seems to be a reliable alternative to the rest standard modelling approaches given the evaluation statistics regarding the predictions of tree heights. Conclusion: Finally, as for providing the most reliable results as compared to the remaining, the resilient propagation algorithm showed its capability of providing more accurate predictions of the tree stem height and thus it can be a reliable alternative to pre-existing modelling methodologies.
Study of the functional product’s protein compounds digestion features
Authors: Vasilevskaya E. R. , Akhremko A. G. , Polishchuk E. K. , Fedulova L. V. 
Published: October 2020

The aim of the study was to investigate the transformation of meat product’s proteins from pig hearts and aortas during enzymatic hydrolysis in an in vitro model of the gastrointestinal tract. The model consisted of three phases simulating digestion processes: “oral cavity” phase (a-amylase, pH 7.0; 2 min), “stomach” phase (pork pepsin, pH 3.0; 120 min), “intestine” phase (pork pancreatin, pH 7.0; 130 min). The product was sequentially subjected to hydrolysis, at the end of each phase, samples were taken to determine the protein concentration (biuret method) and visualize the protein fractions (one-dimensional electrophoresis). A significant increase in protein concentration at the “stomach” phase was revealed by 3.2 times, and the absolute content by 4.6 times. At the “intestine” phase, a decrease in the number of peptide complexes with copper ions by 1.8 times, the absolute protein content by 8.5% was re‑ vealed. The noted tendency was confirmed by electrophoretic studies — at the stage, simulating digestion in the stomach, the prod‑ ucts of meat product’s proteins hydrolysis were visualized; at the “intestine” phase, a low expression of protein fractions in the range of more than 10 kDa is shown. The maximum hydrolysis of protein compounds at the “stomach” phase to poly- and oligopeptides was confirmed, continuing at the “intestine” stage with the accumulation of free amino acids. This methodology makes it possible to visualize the products of hydrolysis of proteins in a meat product at all stages of the model and to monitor changes in protein concentration in the system.
Therapeutic effect of Prdx1 on NAFLD mice may be related to the activation of Nrf-2/HO-1 pathway
Authors: Bai Ru-Xue , Xu Ying-Ying , Chen Yan-Ming , Qin Geng , Wang Hui-Fen , Du Shi-Yu 
Published: October 2020

Objective:
To investigate the effect of peroxiredoxin1 (Prdx1) on the methionine-choline deficient (MCD)-
induced mice model of non-alcoholic fatty liver disease (NAFLD).

Methods:
Wild type (WT), transgenic Prdx1 over-expressing (TG) and Prdx1 knockout (KO) mice were fed with MCD
diet to construct NAFLD model. General parameters was determined followed by detection with HE staining, oil red O
staining, Immunofluorescence, Immunohistochemistry, qRT-PCR and Western blotting. The activities of MDA, GPX and
SOD were also quantified.

Results:
Compared with WT + MCD group, mice in KO + MCD group showed the decresed final weight, food intake and
the levels of glucose, insulin, total cholesterol and triglyceride, accompanying with the increased FFA, ALT and AST, as
well as the aggravated liver histopathology, which was alleviated in TG + MCD group. Also, mice from KO + MCD
group had increased F4/80 and CD68 positive staining with the upregulation of pro-inflammatory and fibrogenic factors in
liver tissues than those from WT + MCD group, as well as the enhanced MDA and the reduced GPX and SOD, while TG
+ MCD group demonstrated improvements than the WT + MCD group. Nrf-2/HO-1 pathway in liver tissues from
NFALD mice was inhibited, and Prdx1-/-
can further reduce the expression of Nrf-2 and HO-1, while Prdx1 overexpression increased Nrf-2 and HO-1 expression.

Conclusion:
Prdx1 improved oxidative stress, inflammation and fibrosis in liver of NAFLD mice, which may be associate
with the activation of Nrf-2/HO-1 pathway.
Repaglinide and Metformin-Loaded Amberlite Resin-Based Floating Microspheres for the Effective Management of Type 2 Diabetes
Authors: Jain Akhlesh K. , Sahu Praveen , Mishra Keerti , Jain Sunil K. 
Published: October 2020

Background:
Low bioavailability of anti-diabetic drugs results in the partial absorption
of the drug as they are mainly absorbed from the stomach and the lower part of the GIT. Drug bioavailability
of anti-diabetic drugs can be significantly increased by prolonging gastric retention time
through gastro-retentive dosage form such as floating microspheres.

Objective:
The study was aimed to develop and characterize resin based floating microspheres of
Repaglinide and Metformin for superior and prolonged maintenance of normoglycaemia in type-2
diabetes mellitus.

Methods:
Repaglinide and metformin were complexed with amberlite resin; later resin complexed
drug was encapsulated in Ethylcellulose floating microspheres. Floating microspheres were characterized
for morphology, particle size, IR spectroscopy, DSC, in vitro release and buoyancy studies.
Further, floating microspheres were tested for in vivo blood glucose reduction potential in Streptozocin-
induced diabetic mice.

Results:
Floating microspheres had spherical shape and slight rough surface with the entrapment efficiency in a range of 49-
78% for Metformin and 52-73% for Repaglinide. DSC studies revealed that no chemical interaction took place between polymer and drugs. Floating microspheres showed good buoyancy behavior (P<0.05) and prolonged drug release as compared
to plain drug (P<0.05). Blood glucose lowering effect of floating microspheres in Streptozocin induced diabetic rats was
significantly greater (P<0.05) and prolonged (˃12h) and normoglycaemia was maintained for 6hr.

Conclusion:
Floating microspheres containing drug resin complex were able to prolong drug release
in an efficient way for a sustained period of time; as a result, profound therapeutic response
was obtained.
Relationship with Metalloproteinase 13, E-cadherin, Homocysteine and Co Factors Folic Acid and Vitamin B12 in Patients Diagnosed with Prostate Cancer
Authors: Gascón Thaís M. , Lourenço Beatriz G. , Pereira Edimar C. , da Costa Aguiar Beatriz A. , Veiga Glaucia L. , de Sousa Gehrke Flavia , Adami Fernando , Fonseca Fernando L.A. 
Published: October 2020

Introduction::
Prostate cancer (Pc) is the most frequent neoplasia in men and the second
cause of death in Brazil.

Objective::
To analyze the interactions and biologicals responses of Pc oxidative stress and prostatespecific
antigen (PSA), E-cadherin and MMP-13. Demonstrate whether the increase of the amount of
the form of E-cadherin found in the plasma of Pc patients, correlates with decrease of the PSA.

Methods::
Samples were obtained through peripheral venipuncture to analyse parameters of biomarkers
pc as PSA, E-cadherin, MMP-13, Homocysteine, Folic acid, Vitamin B12, Testosterone T and free following
the patients diagnosis, 3 and 6 months during their treatment to analyze the biological responses
of Pc oxidative stress.

Results::
The analysis was performed by using immunoenzymatic assay. Statistical data processed
through Excel in Windows Vista and analyzed through the Shapiro-wilk Test, ANOVA, and Spearman
Test. An increase in the concentration of E-cadherin (p = 0.02), as a decrease in concentration of PSA
(p < 0.001), total testosterone (p < 0.001) and free testosterone (p = 0.02) was observed during the
treatment period without significant alterations in the remaining markers for either of the periods.

Discussion::
It was found that during treatment of men diagnosed with pc that there was an an increase
in the concentration of plasmatic E-cadherin, which was negatively correlated with the concentrations
of folic acid (-0,03 (0,87) rs (p). It was observed that the levels of hcy are positively correlated with
concentrations of total testosterone and a negative correlation. Vitamins B12 remained within the parameters
of normality during the entire study.

Conclusion::
P.S.A levels were free and total testosterone levels decreased. In this way, monitoring the
folic acid, E-cadherin dosages of patients during the treatment phases can effectively complement in the
face of remission, since it would be a way of preventing abnormal cell replications, with a clinical view
prudent so that the cell methylation cycle is not affected.
Severe Pancytopenia Following Single Dose Methotrexate In Psoriasis: A Rare And Potentially Lethal Manifestation
Authors: Singh Ajeet , Choudhary Ritul , Chhabra Namrata , Ganguly Satyaki , Rathore Vinay 
Published: October 2020

:Methotrexate is an anti-metabolite, anti-cancer drug frequently used in the treatment of extensive chronic plaque psoriasis. Psoriatic plaque erosion is a rare toxic side effect of single-dose methotrexate and is described as a sign of impending pancytopenia. Here, we report a case of a 48- year-old male presented with multiple oral and genital erosions, accompanied by fissuring over palm and soles for 5 days. His laboratory tests revealed severe pancytopenia and nephropathy. He had a history of chronic plaque psoriasis for which he took a single dose of 15 mg methotrexate. During the hospital stay, the patient needed folate antagonist, granulocyte colony-stimulating factor (G-CSF), intravenous fluids, blood transfusions, and platelet transfusions. He recovered within 12 days of admission.
In Vitro Anti-proliferative Properties of Flavonoids Isolated from Artocarpus Heterophyllus on Cancer Cell Lines
Authors: Mat Daud Nik Nurul Najihah Nik , Abu Bakar Noor Azlina , Septama Abdi Wira 
Published: October 2020

:
Artocarpus heterophyllus has been used as a folk medicine. This plant contained a wide
range of flavonoid compounds and possessed several pharmacological properties including anticancer
properties. Chemotherapeutic agent is a major option for cancer treatment. However, it may
lead to tumor relapse. Therefore, it needs to discover an alternative to reduce this limitation using
natural products.

Objective:
This study was aimed to determine anti-proliferative activities of isolated compounds
against cancer cell lines. The morphological changes of cancer cell lines after treatment with the
compounds was also evaluated.

Methods:
The flavonoid compounds were determined for their cytotoxic activity against leukaemia
HL-60 (CCL-240), colorectal adenocarcinoma HT-29 (HTB-38), breast adenocarcinoma cancer
MCF-7 (HTB-22), and non-small lung cancer H460 (HTB-177) cell lines using MTT assay.
Hoechst 33342/PI staining assay was used to evaluate the morphological changes, and observed using
a fluorescent microscope.

Results:
It showed that amongst compound, artocarpin consistently exhibited strong cytotoxic activity
against H460, HT-29, MCF-7, and HL-60 cancer cell lines with IC50 values of 5.07, 5.56,
12.53, and 19.94 μg/mL, respectively. The activity was comparable to the cisplatin as a positive
control. Morphological observations showed the most typical apoptotic morphology of cancer cells
upon treatment with artocarpin and the least typical of apoptotic structure with other compounds.

Conclusion:
It can be suggested that A. heterophyllus bioactive compound modulates apoptosis by
the presence of its distinctive, typical forms of morphological changes in treating cancer cells.
Thus, artocarpin compound may provide high potential therapeutic use in chemotherapeutic strategies.
Withdrawal Notice: Role, Significance and Association of microRNA-10a/b in Physiology of Cancer
Authors: Elgeshy Khaled M. , Abdel Wahab Abdel Hady A. 
Published: October 2020

The article has been withdrawn by agreement between the editors and publisher ofMicroRNA. The authors are not responding to the editor’s requests to provide the language-edited version.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

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It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submit- ting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.
Evaluating the Safety and Toxicity of a Modified Dextran-based Biopolymer as a Hemostat
Authors: Maleksabet Narges , Masoumian Mohammadreza , Aramvash Asieh 
Published: October 2020

Background:As an effective alternative to conventional suture techniques, topical hemostatic agents are widely used to control bleeding and close wounds in surgeries.Objective:This study was conducted to evaluate the efficacy and safety of a novel hydrogel hemostat that is easy to use in an applicator under normal conditions according to ISO 10993.Methods:The safety of DexGel, a natural surgical hemostat containing mainly dextran that is an effective hydrogel in bleeding stop, was evaluated and compared to that of AristaTM. APTT test and cytotoxicity tests (i.e., MTT assay, Crystal violet assay, and qualitative estimation) were carried out for considering safety in skin sensitization in a guinea pig model.Results:This study has shown that DexGel does not cause any noticeable sensitization such as edema and erythema or observable toxicity for skin and does not disturb the coagulation process. In addition, cytotoxicity results approve its safety for cell survival.Conclusion:It can be concluded that the safety and efficacy of DexGel (5 g) are comparable or even better to that of AristaTM, which is a commercial and frequently used hemostat, and the lack of skin irritation and toxicity for DexGel alleviates initial safety concerns for products based on these polymers and oligomers.
A Mini-Review on Cardiovascular and Hematological Complications of COVID-19
Authors: Masjedi Moein , Jafari Pegah 
Published: October 2020

Background::Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is named as the coronavirus disease of 2019 (COVID-19). Patients with SARS-CoV-2 infection experience a wide range of symptoms and they are at the risk of various systemic complications. Besides the pulmonary complications, COVID-19 cases may develop cardiovascular and hematological complications. This study aimed to review the most important hematological and cardiovascular complications caused by SARS-CoV-2 infection.Methods:The English databases, including Pubmed, ScienceDirect, Cochrane Library, Scopus, and Google Scholar, were searched. The published papers were selected and reviewed based on the subject of this study.Results::The review of the literature showed that several cardiovascular complications related to COVID-19, including acute myocardial infarction, cardiomyopathy, acute heart failure, and venous thromboembolic events due to coagulation abnormalities, have been reported. COVID-19 associated hematological complications include elevated levels of hematological factors including C-reactive protein, lactate dehydrogenase, procalcitonin, and ferritin. Furthermore, the levels of blood cells, including lymphocytes and thrombocytes, can be reduced.Conclusion::This study reviewed COVID-19-associated cardiovascular and hematopoietic complications. In conclusion, the patients may experience a wide range of cardiovascular and hematological issues during the illness. These complications are often associated with the need for ICU support and care which imposes further costs to the healthcare system. So the healthcare team must consider the possible complications when treating COVID-19 patients to reduce the treatment costs and mortality of patients.
Consumers’ Intentions to Adopt Blockchain-Based Personal Health Records and Data Sharing: Focus Group Study
Authors: Lu Chang , Batista Danielle , Hamouda Hoda , Lemieux Victoria 
Published: October 2020

Background
Although researchers are giving increased attention to blockchain-based personal health records (PHRs) and data sharing, the majority of research focuses on technical design. Very little is known about health care consumers’ intentions to adopt the applications.

Objective
This study aims to explore the intentions and concerns of health care consumers regarding the adoption of blockchain-based personal health records and data sharing.

Methods
Three focus groups were conducted, in which 26 participants were shown a prototype of a user interface for a self-sovereign blockchain-based PHR system (ie, a system in which the individual owns, has custody of, and controls access to their personal health information) to be used for privacy and secure health data sharing. A microinterlocutor analysis of focus group transcriptions was performed to show a descriptive overview of participant responses. NVivo 12.0 was used to code the categories of the responses.

Results
Participants did not exhibit a substantial increase in their willingness to become owners of health data and share the data with third parties after the blockchain solution was introduced. Participants were concerned about the risks of losing private keys, the resulting difficulty in accessing care, and the irrevocability of data access on blockchain. They did, however, favor a blockchain-based PHR that incorporates a private key recovery system and offers a health wallet hosted by government or other positively perceived organizations. They were more inclined to share data via blockchain if the third party used the data for collective good and offered participants nonmonetary forms of compensation and if the access could be revoked from the third party.

Conclusions
Health care consumers were not strongly inclined to adopt blockchain-based PHRs and health data sharing. However, their intentions may increase when the concerns and recommendations demonstrated in this study are considered in application design.
Mental Health and Burnout Syndrome Among Postgraduate Students in Medical and Multidisciplinary Residencies During the COVID-19 Pandemic in Brazil: Protocol for a Prospective Cohort Study
Authors: Pinho Rebeca Da Nóbrega Lucena , Costa Thais Ferreira , Silva Nayane Miranda , Barros-Areal Adriana F , Salles André De Mattos , Oliveira Andrea Pedrosa , Rassi Carlos , Valero Caroline Elizabeth Brero , Gomes Ciro Martins , Mendonça-Silva Dayde , Oliveira Fernando , Jochims Isadora , Ranulfo Ivan , Neves Juliana De Brito Seixas , Oliveira Lucas , Dantas Maria Nogueira , Rosal Marta , Soares Mayra , Kurizky Patrícia , Peterle Viviane Uliana , Faro Yasmin Furtado , Gomides Ana Paula , da Mota Licia , Albuquerque Cleandro , Simaan Cezar Kozak , Amado Veronica M 
Published: October 2020

Background
The COVID-19 pandemic has led to high levels of physical, psychological, and social stress among health care professionals, including postgraduate students in medical and multidisciplinary residencies. This stress is associated with the intense fear of occupational exposure to SARS-CoV-2, the virus known to cause COVID-19. These professionals are at risk of developing physical and mental illnesses not only due to the infection but also due to prolonged exposure to multidimensional stress and continued work overload.

Objective
This study aims to evaluate the prevalence of symptoms suggestive of mental disorders and burnout syndrome and determine the risk factors for burnout among postgraduate students in medical and multidisciplinary residencies in Brazil during the COVID-19 pandemic.

Methods
For this prospective cohort study with parallel groups, participants were recruited between July and September 2020 to achieve a sample size of at least 1144 participants. Research instruments such as Depression, Anxiety, and Stress Scale; Patient Health Questionnaire; Brief Resilient Coping Scale; and Oldenburg Burnout Inventory will be used to collect data. Data will be collected in 2 waves: the first wave will include data related to sample characterization and psychosocial evaluation, and the second wave will be launched 12 weeks later and will include an evaluation of the incidence of burnout as well as correlations with the potential predictive factors collected in the first wave. Additionally, we will collect data regarding participants’ withdrawal from work.

Results
The recruitment took place from July 29 to September 5, 2020. Data analyses for this phase is already in progress. The second phase of the study is also in progress. The final data collection began on December 1, 2020, and it will be completed by December 31, 2020.

Conclusions
We believe the findings of this study will help evaluate the impact of the COVID-19 pandemic on the mental health conditions of health professionals in Brazil as well as contribute to the planning and implementation of appropriate measures that can alleviate these mental health challenges.

International Registered Report Identifier (IRRID)
DERR1-10.2196/24298
Is the Online Friendship Scale Fit for High School Students?
Authors: Helmi Avin Fadilla 
Published: October 2020

Online friendship is an inevitable phenomenon especially for young people for which Helmi et al. developed a concept and an online friendship scale with university students as their trial subject. From a developmental perspective, university students are in the early adulthood stage. With the Internet’s asynchronous nature and the absence of non-verbal cues, the scale was applied to high school students in this present study. The purpose of this study was to test whether or not the online friendship scale has sound psychometric properties when applied to high school students. The subjects of this study were 214 high school students. The results of the structural equation model analysis met the goodness of fit criteria for construct validity, which include TL, GFT, and RMSEA indices. Its Cronbach's alpha reliability coefficient was also satisfying. A drive to create activities with friends on social media mitigates the lack of non-verbal signs resulting from online communication. This result supports the social enhancement hypothesis. Consequently, Online Friendship Scale can be implemented in adolescence and young adult.