bluuebunny/crossref_metadata_2025_split huggingface dataset:
NATURE DE LA SYMPTOMATOLOGIE DÉPRESSIVE POSTNATALE VERSUS NON POSTNATALE : UNE ANALYSE QUALITATIVE
Authors: Goron1 Stéphanie , Dupuis Gilles , des Rivières-Pigeon Catherine , Bédard Marie Josée , Reeves Nicole 
Published: November 2020

Il n’y a pas de consensus concernant la spécificité des symptômes de la dépression postnatale (DPP). Cet article rapporte les résultats d’une étude qualitative inductive visant à éclairer les similitudes et les différences entre les symptômes de la DPP vs ceux de la dépression non postnatale (DNP). Le contenu de 20 entretiens de mères en DPP et de 10 mères en DNP a été analysé. Les deux groupes présentent un profil symptomatologique similaire. Les quelques différences observées ne justifient pas la création d’un diagnostic distinct pour la DPP. Toutefois, elles suggèrent des pistes intéressantes pour la prévention de la DPP.
Repercussões emocionais em mulheres que sofreram violência obstétrica
Authors: Assis Karina Goes de , Meurer Fernanda 
Published: November 2020

A violência obstétrica (VO) é um assunto atual e vem despertando o interesse em vários segmentos da sociedade brasileira, bem como na comunidade científica. Refere-se a um conjunto de violências sofrida por mulheres durante a gestação, o parto, período de puerpério ou processo de abortagem, que podem ser de caráter físico, verbal ou psicológico. Este artigo refere-se a uma pesquisa qualitativa do tipo descritiva e exploratória, que teve como objetivo analisar as repercussões da VO em mulheres, conhecer as repercussões emocionais de mulheres que sofreram VO, identificar mudanças na vida sexual e impactos no exercício da maternidade dessas mulheres. Para tanto, foram utilizados relatos de mulheres que sofreram VO publicados em blogs de domínio público. Os dados coletados foram analisados a partir da análise de conteúdo proposta por Bardin e organizados em categorias: impacto emocional na vida das mulheres; impacto nas primeiras interações mãe-bebê e delay para compreender a VO. Através dessa pesquisa foi possível averiguar que buscar a humanização do parto, informar as mulheres com relação aos seus direitos e incluir o combate a VO na formação dos profissionais de saúde é a forma mais eficiente de combater a VO.
Deep learning prediction of likelihood of ICU admission and mortality in COVID-19 patients using clinical variables
Authors: Li Xiaoran , Ge Peilin , Zhu Jocelyn , Li Haifang , Graham James , Singer Adam , Richman Paul S. , Duong Tim Q. 
Published: November 2020

Background
This study aimed to develop a deep-learning model and a risk-score system using clinical variables to predict intensive care unit (ICU) admission and in-hospital mortality in COVID-19 patients.

Methods
This retrospective study consisted of 5,766 persons-under-investigation for COVID-19 between 7 February 2020 and 4 May 2020. Demographics, chronic comorbidities, vital signs, symptoms and laboratory tests at admission were collected. A deep neural network model and a risk-score system were constructed to predict ICU admission and in-hospital mortality. Prediction performance used the receiver operating characteristic area under the curve (AUC).

Results
The top ICU predictors were procalcitonin, lactate dehydrogenase, C-reactive protein, ferritin and oxygen saturation. The top mortality predictors were age, lactate dehydrogenase, procalcitonin, cardiac troponin, C-reactive protein and oxygen saturation. Age and troponin were unique top predictors for mortality but not ICU admission. The deep-learning model predicted ICU admission and mortality with an AUC of 0.780 (95% CI [0.760–0.785]) and 0.844 (95% CI [0.839–0.848]), respectively. The corresponding risk scores yielded an AUC of 0.728 (95% CI [0.726–0.729]) and 0.848 (95% CI [0.847–0.849]), respectively.

Conclusions
Deep learning and the resultant risk score have the potential to provide frontline physicians with quantitative tools to stratify patients more effectively in time-sensitive and resource-constrained circumstances.
Genotype–phenotype correlation in seven motor neuron disease families with novel ALS2 mutations
Authors: Sprute Rosanne , Jergas Hannah , Ölmez Akgün , Alawbathani Salem , Karasoy Hatice , Dafsari Hormos Salimi , Becker Kerstin , Daimagüler Hülya‐Sevcan , Nürnberg Peter , Muntoni Francesco , Topaloglu Haluk , Uyanik Gökhan , Cirak Sebahattin 
Published: November 2020

AbstractAutosomal‐recessive mutations in the Alsin Rho guanine nucleotide exchange factor (ALS2) gene may cause specific subtypes of childhood‐onset progressive neurodegenerative motor neuron diseases (MND). These diseases can manifest with a clinical continuum from infantile ascending hereditary spastic paraplegia (IAHSP) to juvenile‐onset forms with or without lower motor neuron involvement, the juvenile primary lateral sclerosis (JPLS) and the juvenile amyotrophic lateral sclerosis (JALS). We report 11 patients from seven unrelated Turkish and Yemeni families with clinical signs of IAHSP or JPLS. We performed haplotype analysis or next‐generation panel sequencing followed by Sanger Sequencing to unravel the genetic disease cause. We described their clinical phenotype and analyzed the pathogenicity of the detected variants with bioinformatics tools. We further reviewed all previously reported cases with ALS2‐related MND. We identified five novel homozygous pathogenic variants in ALS2 at various positions: c.275_276delAT (p.Tyr92CysfsTer11), c.1044C>G (p.Tyr348Ter), c.1718C>A (p.Ala573Glu), c.3161T>C (p.Leu1054Pro), and c.1471+1G>A (NM_020919.3, NP_065970.2). In our cohort, disease onset was in infancy or early childhood with rapid onset of motor neuron signs. Muscle weakness, spasticity, severe dysarthria, dysphagia, and facial weakness were common features in the first decade of life. Frameshift and nonsense mutations clustered in the N‐terminal Alsin domains are most prevalent. We enriched the mutational spectrum of ALS2‐related disorders with five novel pathogenic variants. Our study indicates a high detection rate of ALS2 mutations in patients with a clinically well‐characterized early onset MND. Intrafamilial and even interfamilial diversity in patients with identical pathogenic variants suggest yet unknown modifiers for phenotypic expression.
A comparative study for the behavior of 3D‐printed and compression molded PLA/POSS nanocomposites
Authors: Meyva‐Zeybek Yelda , Kaynak Cevdet 
Published: November 2020

AbstractBecause of the biocompatible and nontoxic character of both PLA (polylactide) and POSS (Polyhedral Oligomeric Silsesquioxane) nanoparticles, recently being a significant alternative for biomedical parts; the main purpose of this study was to investigate performance of the 3D‐printed PLA/POSS nanocomposites with respect to the compression molded PLA/POSS specimens. Due to the higher uniformity and higher homogeneity in the distribution of POSS nanoparticles in each PLA matrix layer, mechanical tests (tensile, flexural, and toughness) revealed that the improvements in the strength, elastic modulus and fracture toughness values of the 3D‐printed specimens were much higher compared to their compression molded counterparts, the benefits starting from 13% increasing up to 78%. It was also observed that there was almost no deterioration in the physical structure and mechanical properties of the 3D‐printed specimens, even after keeping them 120 days at 37°C in a physiological solution prepared by using the standard PBS (phosphate buffered saline) tablet.
Heads and tails: The notochord develops differently in the cranium and caudal fin of Atlantic Salmon (Salmo salar, L.)
Authors: Kryvi Harald , Nordvik Kari , Fjelldal Per Gunnar , Eilertsen Mariann , Helvik Jon Vidar , Støren Eivind Nagel , Long John H. 
Published: November 2020

AbstractWhile it is well known that the notochord of bony fishes changes over developmental time, less is known about how it varies across different body regions. In the development of the Atlantic salmon, Salmo salar L., cranial and caudal ends of the notochord are overlaid by the formation of the bony elements of the neurocranium and caudal fin, respectively. To investigate, we describe how the notochord of the cranium and caudal fin changes from embryo to spawning adult, using light microscopy, SEM, TEM, dissection, and CT scanning. The differences are dramatic. In contrast to the abdominal and caudal regions, at the ends of the notochord vertebrae never develop. While the cranial notochord builds a tapering, unsegmented cone of chordal bone, the urostylic notochordal sheath never ossifies: adjacent, irregular bony elements form from the endoskeleton of the caudal fin. As development progresses, two previously undescribed processes occur. First, the bony cone of the cranial notochord, and its internal chordocytes, are degraded by chordoclasts, an undescribed function of the clastic cell type. Second, the sheath of the urostylic notochord creates transverse septae that partly traverse the lumen in an irregular pattern. By the adult stage, the cranial notochord is gone. In contrast, the urostylic notochord in adults is robust, reinforced with septae, covered by irregularly shaped pieces of cellular bone, and capped with an opistural cartilage that develops from the sheath of the urostylic notochord. A previously undescribed muscle, with its origin on the opistural cartilage, inserts on the lepidotrich ventral to it.
Comparison of Chloroaluminate Melts for Aluminum Graphite Dual‐Ion Battery Application
Authors: Elia Giuseppe Antonio , Hoeppner Katrin , Hahn Robert 
Published: November 2020

AbstractHerein, we report a comparison of aluminum graphite dual‐ion cells (AGDICs) electrochemical characteristics employing the conventional 1‐ethyl‐3‐methylimidazolium chloride:aluminum trichloride (EMIMCl : AlCl3) electrolyte and two popular deep eutectic solvents (DESs), namely urea : AlCl3 and acetamide:AlCl3. The three electrolytes′ characteristics have been evaluated in terms of Al‐stripping deposition capability and cycling behavior in AGDICs. The results evidence the EMIMCl : AlCl3′s Al‐stripping deposition and rate capability in AGDICs superior characteristics addressed to the lower viscosity and higher conductivity with respect to the urea : AlCl3 and acetamide:AlCl3. On the other hand, the urea : AlCl3 guarantees a much higher columbic efficiency in AGDICs, thanks to the superior electrochemical window stability.
Publishing in education: A parallel session at the IUBMB/PSBMB 2019 “Harnessing Interdisciplinary Education in Biochemistry and Molecular Biology” conference
Authors: Bascos Neil Andrew D. , Craig Paul A. , Lapeña Jose Florencio F. , Ortiz Phillip , Yu Gracia Fe B. , Macaulay Janet O. 
Published: November 2020

AbstractEnsuring currency with trends, knowledge, and understanding of teaching and learning is essential for all educators. Researching learning and teaching is an enormous field which can range from examining the practical impact of new classes to research into the processes of learning. The “Publishing in Education” conference session discussed some of the approaches and outcomes of researching and publishing in education.
CHIP fellowships: Carving a path for complex PCI
Authors: Kalra Sanjog , Seth Ashok 
Published: November 2020

Key Points
Dedicated CHIP training can improve access and outcomes for high‐risk patients needing revascularization.
Given the variability in current CHIP training programs, uniformity in institutional training standards and case matrix may be an important step to achieve proficiency in all key CHIP skill domains and ensure a smooth transition to practice.
Though CHIP procedures carry higher costs, overall contribution margins remain positive.
Drug‐coated balloon angioplasty and 1 month DAPT strategy: Insights from the real world
Authors: Musumeci Giuseppe , Albani Stefano 
Published: November 2020

Key Points
The use of short‐term dual antiplatelet therapy (DAPT) (1 month) may be safe after drug‐coated balloon (DCB) angioplasty.
This study suggests no risk of major cardiovascular adverse events at 6 months after a DCB angioplasty and 1 month DAPT regimen.
Randomized trials are needed to confirm the present data.
Safety and efficacy of paclitaxel drug‐coated balloon treatment of femoropopliteal claudicants: Data and analytic methods matter
Authors: Winscott John G. , Hillegass William B. 
Published: November 2020

Key Points
Claudicants with femoropopliteal disease average 25% higher primary patency and reduced target lesion revascularization long term with crystalline paclitaxel eluting stent and balloon treatment compared to uncoated devices. In animal models, local and downstream tissues have detectable paclitaxel for greater than 180 days.
Aggregate data meta‐analyses of 28 randomized trials suggested 50–100% higher all‐cause mortality with paclitaxel device treatment.
In contrast, more complete ascertainment of follow‐up and pooled individual patient data analyses do not find significantly increased mortality, a dose‐mortality relationship, or an unexpected cause of death pattern with paclitaxel eluting device treatment in femoropopliteal claudicants.
Aortic valve replacement plus revascularization: The battle of surgical versus transcatheter approach still rages
Authors: Tarantini Giuseppe , Fraccaro Chiara 
Published: November 2020

Key Points
The current guidelines for primary aortic valve disease suggest, with different class of recommendation, concomitant coronary artery revascularization in all candidates to aortic valve replacement with angiographic evidence of significant coronary artery diameter stenosis (≥70%, ≥50% for left main stenosis) both for surgical or transcatheter approach.
Initial (non‐patient‐level) pooled data analyses suggest that a percutaneous transcatheter approach confers similar outcomes compared to a surgical approach in patients with severe AS and CAD.
Further scientific evidences from RCTs are warranted to clarify the prognostic impact of CAD on TAVR candidates and to identify the most appropriate revascularization strategy.
Super elastic system using parallel spine frames with steel braces
Authors: Chen Xingchen , Tagawa Hiroshi 
Published: November 2020

AbstractTo reduce the seismic response and residual deformation of structures, this study proposes a super elastic bracing system comprising parallel spine frames with steel rods acting as the braces connecting adjacent spine frames. The brace‐end connections are located on the outer side of the pin supports of spine frames to ensure that the axial deformation of the braces is lower than that of a regular bracing system with identical brace angles. To verify the feasibility and elastic range of the proposed system, cyclic loading tests were conducted using scaled specimens consisting of two spine frames with four different brace configurations. Numerical models created in OpenSees were used to simulate the loading tests appropriately. Four evaluation methods were developed for predicting the force and deformation relation considering the geometrical nonlinearity of the proposed system. Through parametric analyses, the influence of key parameters on structural behaviors is clarified, and the applicability of the evaluation methods is investigated.
Voxel‐Based quantitative MRI reveals spatial patterns of grey matter alteration in multiple sclerosis
Authors: Lommers Emilie , Guillemin Camille , Reuter Gilles , Fouarge Eve , Delrue Gaël , Collette Fabienne , Degueldre Christian , Balteau Evelyne , Maquet Pierre , Phillips Christophe 
Published: November 2020

AbstractDespite robust postmortem evidence and potential clinical importance of gray matter (GM) pathology in multiple sclerosis (MS), assessing GM damage by conventional magnetic resonance imaging (MRI) remains challenging. This prospective cross‐sectional study aimed at characterizing the topography of GM microstructural and volumetric alteration in MS using, in addition to brain atrophy measures, three quantitative MRI (qMRI) parameters—magnetization transfer (MT) saturation, longitudinal (R1), and effective transverse (R2*) relaxation rates, derived from data acquired during a single scanning session. Our study involved 35 MS patients (14 relapsing–remitting MS; 21 primary or secondary progressive MS) and 36 age‐matched healthy controls (HC). The qMRI maps were computed and segmented in different tissue classes. Voxel‐based quantification (VBQ) and voxel‐based morphometry (VBM) statistical analyses were carried out using multiple linear regression models. In MS patients compared with HC, three configurations of GM microstructural/volumetric alterations were identified. (a) Co‐localization of GM atrophy with significant reduction of MT, R1, and/or R2*, usually observed in primary cortices. (b) Microstructural modifications without significant GM loss: hippocampus and paralimbic cortices, showing reduced MT and/or R1 values without significant atrophy. (c) Atrophy without significant change in microstructure, identified in deep GM nuclei. In conclusion, this quantitative multiparametric voxel‐based approach reveals three different spatially‐segregated combinations of GM microstructural/volumetric alterations in MS that might be associated with different neuropathology.
Value of preoperative HE4 as predictor of advanced disease in endometrioid endometrial cancer
Authors: Espiau Romera Andrea , Coronado Martín Pluvio Jesús , Chóliz Ezquerro Marta , Cuesta Guardiola Tatiana , Adiego Calvo Ignacio , Baquedano Mainar Laura 
Published: November 2020

ABSTRACTObjectiveTo explore the predictive value of serum human epididymis protein 4 (HE4) marker in the preoperative prediction of the risk of advanced disease in the endometrioid subtype of endometrial cancer, and its association with poor prognostic factors. In addition, a cut‐off value of HE4 was defined to classify patients according to these results.MethodsProspective and multicenter cohort analytical pilot study of patients operated for endometrial cancer at the Miguel Servet University Hospital of Zaragoza (Spain) and the Complejo Universitario of León (Spain) from January 2017 to May 2019. Preoperative serum levels of HE4 were analyzed by clinical and pathologic characteristics.ResultsIn all, 126 patients were included. A statistically significant association was found between the preoperative HE4 value and node involvement (P = 0.008), late‐stage disease (P = 0.003), high histologic grade (P = 0.007), deep myometrial invasion (P = 0.001), lymphovascular space invasion (P = 0.001), and other pathologic factors. In addition, an HE4 cut‐off value (156.4 pmol/L) has been determined to predict, preoperatively, which patients will present with early stage disease.ConclusionsThe preoperative marker HE4 is a useful tool in the preoperative study of patients with endometrial cancer as it relates to late‐stage disease as well as other prognostic factors in the endometrioid subtype of endometrial cancer.
Test utilization for the diagnosis of vitamin B12 and folate deficiency in local clinics in Korea
Authors: Choi Rihwa , Oh Youngju , Park Mi‐Jung , Kim Serim , Kim Youngrae , Lee Sang Gon , Lee Eun Hee 
Published: November 2020

AbstractBackgroundCurrent guidelines pertaining to diagnosing macrocytic anemia in association with vitamin B12 and folate deficiency recommend that vitamin B12, folate, homocysteine, and methylmalonic acid assays should be assessed concurrently due to their close relationship in metabolism. We aimed to investigate the completion of these assays in local clinics and hospitals without in‐house clinical laboratories in Korea.MethodsWe retrospectively reviewed data from the laboratory information system between September 25, 2017, and June 30, 2019, to investigate usage rates of vitamin B12, folate, homocysteine, and methylmalonic acid assays in patients with macrocytic anemia.ResultsDuring the study period, 14 894 Korean adults among 109 524 (13.6%) total hemoglobin‐tested subjects underwent concurrent erythrocyte mean corpuscular volume (MCV) tests. Among these 14,894 adults, 265 (1.2%) from 94 local clinics or hospitals without in‐house clinical laboratories in Korea had macrocytic anemia. Furthermore, among these 265 adults, only one woman underwent serum vitamin B12 and folate assay and one man underwent serum homocysteine testing during the study period. No patients among the 265 individuals with macrocytic anemia received erythrocyte folate or methylmalonic acid testing (with either serum, plasma, random urine, or 24‐hour collected urine).ConclusionsThe results of this study provide basic information regarding utilization rates of assays in association with vitamin B12 and folate deficiency. Making more data available is expected to improve rates of testing in patients with macrocytic anemia in local clinics and hospitals without in‐house clinical laboratories in Korea.
Mental pain intensity and tolerance as predictors of psychotherapy process and outcome
Authors: Grossman‐Giron Ariella , Becker Gideon , Kivity Yogev , Shalev Shani , Tzur Bitan Dana 
Published: November 2020

AbstractBackgroundThe extensive reliance on symptoms for the study of psychotherapy is often criticized. In this study we examined whether the subjective sense of mental pain predicts psychotherapy process and outcome, above and beyond the effect of symptomatic distress.MethodsOutpatients (n = 53) treated in a psychiatric hospital completed measures of mental pain intensity and tolerance, symptomatic distress, and session climate at pretreatment and posttreatment. Multilevel modeling was utilized to assess the predictive effect of mental pain, while controlling baseline symptomatic distress.ResultsPatients with high mental pain at baseline showed significant reductions in distress, while patients with low mental pain showed no significant improvement. Moreover, low mental pain and high mental pain tolerance predicted decreases in session smoothness.ConclusionsMental pain can serve as a predictive marker for psychotherapy process and outcome, and complement the reliance on symptomatic distress in psychotherapy research.
Exposure‐Response Analyses for Upadacitinib Efficacy in Subjects With Atopic Dermatitis—Analyses of Phase 2b Study to Support Selection of Phase 3 Doses
Authors: Mohamed Mohamed‐Eslam F. , Gopalakrishnan Sathej , Teixeira Henrique D. , Othman Ahmed A. 
Published: November 2020

AbstractUpadacitinib is a selective Janus kinase 1 inhibitor that was recently approved for treatment of rheumatoid arthritis and is currently being evaluated for treatment of several other autoimmune diseases, including atopic dermatitis (AD). The relationships between upadacitinib plasma exposure and efficacy (assessed as Eczema Area Severity Index [EASI]‐75, EASI‐90, and Investigator Global Assessment [IGA] 0/1) in subjects with moderate to severe atopic dermatitis were characterized using the data from 167 subjects who were enrolled in a phase 2b dose‐ranging study. Subjects were randomized to receive once daily doses of monotherapy treatment with upadacitinib extended‐release 7.5, 15, or 30 mg or placebo for 16 weeks. Logistic regression models were developed and utilized to simulate efficacy for upadacitinib with an approximate phase 3 sample size. Based on exposure‐response models, 15 mg once daily is predicted to achieve EASI‐75, EASI‐90, and IGA 0/1 responses in 48%, 26%, and 29% of subjects, respectively, compared with placebo responses of 9%, 2%, and 2%, respectively, whereas 30 mg once daily is predicted to provide an additional approximately 20% greater efficacy for these end points relative to 15 mg once daily. These analyses supported the selection of upadacitinib doses that are being evaluated in ongoing global phase 3 studies in atopic dermatitis.