bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Extratropical Linear Step Response to Tropical Precipitation Anomalies and Its Use in Constraining Projected Circulation Changes under Climate Warming
Authors: Deb Pranab , Matthews Adrian J. , Joshi Manoj M. , Senior Natasha 
Published: July 2020

AbstractRossby wave trains triggered by tropical convection strongly affect the atmospheric circulation in the extratropics. Using daily gridded observational and reanalysis data, we demonstrate that a technique based on linear response theory effectively captures the linear response in 250-hPa geopotential height anomalies in the Northern Hemisphere using examples of steplike changes in precipitation over selected tropical areas during boreal winter. Application of this method to six models from phase 5 of the Coupled Model Intercomparison Project (CMIP5), using the same tropical forcing, reveals a large intermodel spread in the linear response associated with intermodel differences in Rossby waveguide structure. The technique is then applied to a projected tropicswide precipitation change in the HadGEM2-ES model during 2025–45 December–February, a period corresponding to a 2°C rise in the mean global temperature under the RCP8.5 scenario. The response is found to depend on whether the mean state underlying the technique is calculated using observations, the present-day simulation, or the future projection; indeed, the bias in extratropical response to tropical precipitation because of errors in the basic state is much larger than the projected change in extratropical circulation itself. We therefore propose the linear step response method as a semiempirical method of making near-term future projections of the extratropical circulation, which should assist in quantifying uncertainty in such projections.
The Large-Scale Vorticity Balance of the Antarctic Continental Margin in a Fine-Resolution Global Simulation
Authors: Palóczy André , McClean Julie L. , Gille Sarah T. , Wang He 
Published: July 2020

ABSTRACTThe depth-integrated vorticity budget of a global, eddy-permitting ocean/sea ice simulation over the Antarctic continental margin (ACM) is diagnosed to understand the physical mechanisms implicated in meridional transport. The leading-order balance is between the torques due to lateral friction, nonlinear effects, and bottom vortex stretching, although details vary regionally. Maps of the time-averaged depth-integrated vorticity budget terms and time series of the spatially averaged, depth-integrated vorticity budget terms reveal that the flow in the Amundsen, Bellingshausen, and Weddell Seas and, to a lesser extent, in the western portion of East Antarctica, is closer to an approximate topographic Sverdrup balance (TSB) compared to other segments of the ACM. Correlation and coherence analyses further support these findings, and also show that inclusion of the vorticity tendency term in the response (the planetary vorticity advection and the bottom vortex stretching term) increases the correlation with the forcing (the vertical net stress curl), and also increases the coherence between forcing and response at high frequencies across the ACM, except for the West Antarctic Peninsula. These findings suggest that the surface stress curl, imparted by the wind and the sea ice, has the potential to contribute to the meridional, approximately cross-slope, transport to a greater extent in the Amundsen, Bellingshausen, Weddell, and part of the East Antarctic continental margin than elsewhere in the ACM.
Utility of Spirometry Values for Evaluating Tracheal Stenosis Patients Before and After Balloon Dilation
Authors: Alrabiah Abdulaziz , Almohanna Shahad , Aljasser Abdullah , Zakzouk Abdulmajeed , Habib Syed Shahid , Almohizea Mohammed , Bukhari Manal , Alammar Ahmed 
Published: July 2020

Objectives: Tracheal stenosis is defined as a narrowing of the airway distal to the lower edge of the cricoid cartilage. It is initially diagnosed based on clinical presentation and then confirmed using direct laryngobronchoscopy. Other adjunctive diagnostic methods, including spirometry, have been proposed. This study aimed to evaluate the relationship between tracheal stenosis severity and pre- and post-balloon dilatation spirometry parameters in order to assess for significant changes in spirometry values and to evaluate for the effects of stenosis-associated factors on post-dilation spirometry values, including vertical length and grade of the stenosis, as well as the role of wound-modifying agents. Methods: This retrospective study included adults (>18 years of age) with isolated tracheal stenosis who underwent endoscopic balloon dilations at King Saud University Medical City from June 2015 to May 2019, with detailed documentation of operative findings and valid spirometry measurements pre- and post-balloon dilation. Basic demographic data and operative note details, including information about the percentage of tracheal stenosis, distance of tracheal stenosis from vocal cords, vertical length of stenotic segment, and use of wound-modifying agents (topical mitomycin C or triamcinolone injections), were extracted. Results: Fourteen patients with spirometry measurements obtained on 50 occasions (25 pre-balloon dilation and 25 post-balloon dilation) were included. Each 1-unit increase in the vertical length of the stenosis showed a statistically significant negative relationship (−1.47 L/s) with pre-balloon dilation peak expiratory flow (PEF; P = .034). Post-balloon dilation spirometric values showed statistically significant improvements for most variables. Conclusions: The vertical length of an isolated tracheal stenosis can be predicted before surgical interventions using PEF values and may be a significant indicator of anticipated post-balloon dilation surgical success. Our study suggested that spirometry is a very useful technique for evaluating patients with tracheal stenosis due to its noninvasiveness, cost-effectiveness, with a good clinical value.
Prediction of Minor Salivary Gland Carcinoma: A Novel Nomogram and Risk Classification System for Overall Survival and Cancer‐Specific Survival
Authors: lan Ling‐feng , Gao Chen‐kai , Ma Chao‐wu 
Published: July 2020

ObjectiveMinor salivary gland carcinoma (MiSGC) is rare, and the understanding of this disease is insufficient. This study aimed to identify independent risk factors and develop a nomogram for evaluating the overall survival (OS) and cancer‐specific survival (CSS) of patients with MiSGC.Study DesignRetrospective cohort study.SettingSEER database (Surveillance, Epidemiology, and End Results).Subjects and MethodsWe collected data from patients diagnosed with MiSGC between 2004 and 2015 from the SEER database. According to patient registration, all patients were randomly allocated to training sets and validation sets (2:1). Then, Kaplan‐Meier product limit curves and Cox proportional hazard regressions were performed to estimate the prognostic effect of variables. Nomograms based on Cox proportional hazard regressions were established to estimate 3‐ and 5‐year OS and CSS. Finally, the nomogram was developed by the training set, and validation was performed with the concordance index, calibration curves, and decision curve analyses.ResultsIn total, 1787 MiSGC cases were registered in SEER. The concordance index for internal validation of OS and CSS prediction was 0.842 and 0.816; that of external validation was 0.871 and 0.831. The calibration plots showed good consistency between nomogram prediction and actual survival. The decision curve analysis showed substantial net benefits of the new predictive model.ConclusionsWe constructed nomograms and a corresponding risk classification system predicting the OS and CSS of patients with MiSGC. These tools can generate simple‐to‐use clinical risk grouping and determine the relationship between adjuvant therapy and active surveillance.
Relationship Between Pepsin Expression and Dysplasia Grade in Patients With Vocal Cord Leukoplakia
Authors: Chen Ya‐Lian , Bao Yang‐Yang , Zhou Shui‐Hong , Yao Hong‐Tian , Chen Zhe 
Published: July 2020

ObjectiveTo measure pepsin expression in patients with vocal fold leukoplakia and elucidate its clinical significance.Study DesignRetrospective analysis of pathologic archive specimens.SettingAffiliated university hospital.Subjects and MethodsThe study included 45 patients with vocal fold leukoplakia and 19 with vocal fold polyps who underwent surgical treatment between December 2013 and July 2016. Masses were detected on both vocal cords in 5 patients with vocal fold leukoplakia and in 1 patient with vocal fold polyps. Immunohistochemistry was used to assess pepsin expression. In addition, the relationship of pepsin expression level with clinical characteristics of vocal fold leukoplakia was assessed.ResultsThe rate of pepsin expression was high in the polyp group (75%) and the leukoplakia group (68%); however, the difference between groups was not significant (P >. 05). Pepsin expression significantly increased according to grade of dysplasia (mild, 57.1%; moderate, 88.9%; severe, 100.0%; P =. 034). Similarly, the percentage of lesions that exhibited strongly positive pepsin expression increased with the grade of dysplasia (mild, 37.1%; moderate, 66.7%; severe, 100.0%; P =. 005). The leukoplakia recurrence rate was higher in patients with positive pepsin expression than in patients with negative pepsin expression but without a significant difference (P >. 05).ConclusionOur study suggests that pepsin was associated with the grade of dysplasia of vocal cord leukoplakia. Further investigation with appropriate control groups and controlling for other risk factors, such as smoking or alcohol consumption, is needed.
Surgical Management of Bilateral Vocal Fold Paralysis in Children: A Systematic Review and Meta‐analysis
Authors: Thorpe Ryan Kendall , Kanotra Sohit Paul 
Published: July 2020

ObjectivesTo examine and compare the outcomes of various types of glottic widening surgery (GWS) for initial management of bilateral vocal fold paralysis (BVFP) in children, the outcomes of different GWS procedures in children who underwent initial tracheostomy, and the rate of decannulation in children who underwent tracheostomy alone versus tracheostomy followed by GWS.Data SourcesPubMed, Web of Science, Cochrane Library, and Embase were searched following the PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta‐analyses) on September 9, 2019, with no date restriction.Review MethodsArticles focusing on GWS or tracheostomy for initial management of BVFP were included. Articles describing patients who received no surgical intervention for BVFP were excluded.ResultsA total of 5989 articles were reviewed: 67 articles met inclusion criteria, and 240 patients were incorporated into the analysis. Patients who underwent primary GWS had an eventual tracheostomy rate of 6.0% (5/83). There were no statistically significant differences in the rate of tracheostomy, reoperation, or mortality among cricoid split, suture lateralization, and cordectomy/cordotomy. Patients who underwent primary tracheostomy failed to achieve decannulation in 36.9% (58/157) of cases. Decannulation was more likely in tracheostomized children who received GWS than those who did not (odds ratio, 6.336; P <. 0001).ConclusionsMost children who undergo primary GWS for BVFP avoid tracheostomy or reoperation. These data demonstrated no differences in surgical outcomes among the most common types of GWS for BVFP. For children who receive a tracheostomy as their first intervention for BVFP, GWS is associated with a significantly improved rate of decannulation.
Addition of specific hip strengthening exercises to conventional rehabilitation therapy for low back pain: a systematic review and meta-analysis
Authors: de Jesus Fabio Luciano Arcanjo , Fukuda Thiago Yukio , Souza Camila , Guimarães Janice , Aquino Leticia , Carvalho Gabriel , Powers Christopher , Gomes-Neto Mansueto 
Published: July 2020

Objective: To examine the effectiveness of hip strengthening exercises in reducing pain and disability in persons with low back pain. Methods: We searched for randomized controlled clinical trials on MEDLINE, the Physiotherapy Evidence Database, the Cochrane Central Register of Controlled Trials, LILACS, Scielo and CINAHL from the earliest date available to June 2020. Studies that included hip strengthening exercises for persons with low back pain and included pain and/or disability as an outcome measure were evaluated by two independent reviewers. Mean difference (MD), and 95% confidence interval (CI) were estimated by random effect models. Results: Five studies met the eligibility criteria (309 patients). Four studies included hip strengthening in conjunction with other interventions, while one study evaluated hip strengthening as a standalone intervention. Hip strengthening exercises improved pain (MD −5.4 mm, 95% CI: −8.9 to −1.8 mm), and disability (MD −2.9; 95% CI: −5.6 to −0.1) in persons with low back pain compared to interventions in which hip strengthening was not utilized. The quality of evidence for the pain outcome, was assessed as being moderate. The quality of evidence for the outcome of self-reported disability, was assessed as being low. Conclusion: Addition of specific hip strengthening exercises to conventional rehabilitation therapy may be beneficial for improving pain and disability in persons with low back pain.
Ganglioside GM2: a potential biomarker for cholangiocarcinoma
Authors: Talabnin Krajang , Talabnin Chutima , Kumagai Tadahiro , Sutatum Nuchanard , Khiaowichit Juthamas , Dechsukhum Chawaboon , Ishihara Mayumi , Azadi Parastoo , Sripa Banchob 
Published: July 2020

Objective To investigate the expression of glycosphingolipids in serum and tissue from patients with cholangiocarcinoma compared with healthy controls. Methods Nanospray ionization-linear ion trap mass spectrometry (NSI-MSn) was used to demonstrate the comparative structural glycomics of glycosphingolipids in serum from patients with cholangiocarcinoma (n=15), compared with healthy controls (n = 15). GM2 expression in cholangiocarcinoma tissues (n = 60) was evaluated by immunohistochemistry. Results Eleven glycosphingolipids were detected by NSI-MSn: CMH (ceramide monohexose), Lac-Cer (galactose (Gal)β1-4 glucose (Glc)β1-1'-ceramide), Gb3 (Galα1-4Galβ1-4Glcβ1-1'-ceramide), Gb4/Lc4 (N-acetylgalactosamine (GalNAc)β1-3Galα1-4Galβ1-4Glcβ1-1'-ceramide/Galβ1-4 N-acetylglucosamine (GlcNAc)β1-3Galβ1-4Glcβ1-1'-ceramide), GM3 (N-acetylneuraminic acid (NeuAc)2-3Galβ1-4Glcβ1-1'-ceramide), GM2 (GalNAcβ1-4[NeuAc2-3]Galβ1-4Glcβ1-1'-ceramide), GM1 (Galβ1-3GalNAcβ1-4[NeuAc2-3]Galβ1-4Glcβ1-1'-ceramide), hFA (hydroxylated fatty acid)-CMH, hFA-Lac-Cer, hFA-Gb3, and hFA-GM3. Lac-Cer was the most abundant structure among the lactosides and globosides (normal, 24.40% ± 0.11%; tumor, 24.61% ± 2.10%), while GM3 predominated among the gangliosides (normal, 29.14% ± 1.31%; tumor, 30.53% ± 4.04%). The two glycosphingolipids that significantly differed between healthy controls and patients with cholangiocarcinoma were Gb3 and GM2. High expression of GM2 was associated with vascular invasion in tissue from patients with cholangiocarcinoma. Conclusions Altered expression of glycosphingolipids in tissue and serum from patients with cholangiocarcinoma may contribute to tumor growth and progression. The ganglioside GM2, which significantly increased in the serum of patients with cholangiocarcinoma, represents a promising target as a biomarker for cholangiocarcinoma.
Pretargeted radioimmunoimaging with a biotinylated D-D3 construct and 99mTc-DTPA-biotin: strategies for early diagnosis of small cell lung cancer
Authors: Hong Zhihui , Deng Shengming , Shi Yizhen , Xie Yichi , You Jiaxi , Wang Wei , Huang Hong , Liu Zengli 
Published: July 2020

Objective Pro-gastrin releasing peptide (ProGRP) plays an oncogenic role in small cell lung cancer (SCLC). The anti-ProGRP(31-98) monoclonal antibody D-D3 can selectively accumulate in SCLC xenografts in nude mice. This study evaluated the effectiveness of a new pretargeting procedure for the early diagnosis of SCLC. Methods D-D3 was radiolabeled with technetium-99m (99mTc) using a three-step pretargeting method. Mice with SCLC xenografts were treated with different labeling regimens, and the biodistribution and radioimmunoimaging were explored. The percentage injected dose per gram (%ID/g) in various organs, tumor/non-tumor (T/NT) ratio, and tumor/background (T/B) ratio were also calculated. Results In vivo distribution experiments revealed that 99mTc-DTPA-biotin was metabolized in the liver and kidney, with rapid elimination in the blood. The T/B ratio was highest in mice treated with biotinylated antibody D-D3 + avidin + 99mTc-DTPA-biotin. Single-photon emission computerized tomography imaging further confirmed that the T/B ratio was highest in this group at all time points. Conclusions In contrast to directly labeled D-D3, pretargeting technology displayed specific enhancement and signal amplification in tumors, which could increase the target tumor uptake of 99mTc and provide a new approach for the early diagnosis of SCLC.
Dyslipidemia With Perioperative Statin Usage Is Not Associated With Poorer 24-Month Functional Outcomes After Arthroscopic Rotator Cuff Surgery
Authors: Zeng Gerald Joseph ShengXiang , Lee Merrill Jian Hui , Chen Jerry Yongqiang , Ang Benjamin Fu Hong , Hao Ying , Lie Denny Tjiauw Tjoen 
Published: July 2020

Background: Current literature suggests a higher rate of rotator cuff disease development in patients with dyslipidemia (DL). Moderate to high levels of DL are associated with higher rates of retear and revision surgery after arthroscopic rotator cuff repair. Statins protect against development of rotator cuff disease and mitigate the need for rotator cuff repair. Purpose: We aimed to investigate the influence of DL and statin use on postoperative functional outcomes. Study Design: Cohort study; Level of evidence, 3. Methods: Between 2010 and 2016, 266 patients underwent arthroscopic double-row rotator cuff repair for atraumatic full-thickness tears. Evaluation was conducted preoperatively and at 3, 6, 12, and 24 months postoperatively. Three functional outcome measures were used (Constant Shoulder Score [CSS], Oxford Shoulder Score [OXF], and University of California, Los Angeles, Shoulder Rating Scale [UCLASS]), as well as a visual analog scale (VAS) for pain. DL and non-DL were classified through screening of health and assessment of lipid levels within 6 months of surgery (triglycerides, total cholesterol, low-density lipoprotein, and high-density lipoprotein). Patients with DL were divided into statin users and nonusers. Types and dosages of statins were recorded, and intensity and equivalency charts were employed for standardization. Mann-Whitney U test and Pearson chi-square test were used for analysis. Generalized estimating equations and linear mixed models were used to examine the influence of DL and statin dosage, respectively on percentage change of postoperative outcome scores. Results: Increased age was associated with a higher incidence of DL ( P < .001), and 86% of the DL group was taking statins. The DL group also exhibited poorer scores preoperatively (CSS, P = .001; OXF, P = .032). No significant difference in scores was elicited between the DL and non-DL groups at 24 months. However, patients with DL experienced greater percentage improvement of CSS and OXF from preoperative baseline than did patients without DL ( P = .008 and P = .034, respectively) at 24 months. There was no significant difference in 24-month functional outcomes between statin users and nonusers. No statistically significant change of CSS; OXF; UCLASS; or VAS was noted with increasing statin doses at 24 months. Conclusion: Patients with DL with perioperative statin usage did not have poorer 24-month functional outcomes after arthroscopic rotator cuff surgery compared with those in patients without DL.
Linear Discriminant Analysis Successfully Predicts Knee Injury Outcome From Biomechanical Variables
Authors: Schilaty Nathan D. , Bates Nathaniel A. , Kruisselbrink Sydney , Krych Aaron J. , Hewett Timothy E. 
Published: July 2020

Background: The most commonly damaged structures of the knee are the anterior cruciate ligament (ACL), medial collateral ligament (MCL), and menisci. Given that these injuries present as either isolated or concomitant, it follows that these events are driven by specific mechanics versus coincidence. This study was designed to investigate the multiplanar mechanisms and determine the important biomechanical and demographic factors that contribute to classification of the injury outcome. Hypothesis: Linear discriminant analysis (LDA) would accurately classify each injury type generated by the mechanical impact simulator based on biomechanical input variables (ie, ligament strain and knee kinetics). Study Design: Controlled laboratory study. Methods: In vivo kinetics and kinematics of 42 healthy, athletic participants were measured to determine stratification of injury risk (ie, low, medium, and high) in 3 degrees of knee forces/moments (knee abduction moment, anterior tibial shear, and internal tibial rotation). These stratified kinetic values were input into a cadaveric impact simulator to assess ligamentous strain and knee kinetics during a simulated landing task. Uniaxial and multiaxial load cells and implanted strain sensors were used to collect mechanical data for analysis. LDA was used to determine the ability to classify injury outcome by demographic and biomechanical input variables. Results: From LDA, a 5-factor model (Entropy R2 = 0.26) demonstrated an area under the receiver operating characteristic curve (AUC) for all 5 injury outcomes (ACL, MCL, ACL+MCL, ACL+MCL+meniscus, ACL+meniscus) of 0.74 or higher, with “good” prediction for 4 of 5 injury classifications. A 10-factor model (Entropy R2 = 0.66) improved the AUC to 0.86 or higher, with “excellent” prediction for 5 injury classifications. The 15-factor model (Entropy R2 = 0.85), produced 94.1% accuracy with the AUC 0.98 or higher for all 5 injury classifications. Conclusion: Use of LDA accurately predicted the outcome of knee injury from kinetic data from cadaveric simulations with the use of a mechanical impact simulator at 25° of knee flexion. Thus, with clinically relevant kinetics, it is possible to determine clinical risk of injury and also the likely presentation of singular or concomitant knee injury. Clinical Relevance: LDA demonstrates that injury outcomes are largely characterized by specific mechanics that can distinguish ACL, MCL, and medial meniscal injury. Furthermore, as the mechanics of injury are better understood, improved interventional prehabilitation can be designed to reduce these injuries.