bluuebunny/crossref_metadata_2025_split huggingface dataset:
Finite element analysis of interior slab‐column connections strengthened by steel angle plates
Authors: Taresh Hussein R. , Md Yatim Mohd Yazmil , Azmi Mohd Reza 
Published: August 2020

AbstractThis paper is concerned with the finite element modeling of strengthened interior slab‐column connections in the existing continuous flat slab structural system by employing steel angle plates at the slab‐column junctions and fastened by shear bolts. This technique utilizes the advantage of combined action between the angle plates and bolts in resisting shear particularly at the slab‐column edges. Three‐dimensional analysis was carried out on such slabs employing concrete damaged plasticity model in ABAQUS to investigate their performance in terms of punching shear resistance, load–displacement response, and crack pattern at failure. The numerical models were first validated against the experimental results reported by other researchers. The proposed strengthening technique results in a substantial increase of load‐carrying capacity ranging from about 59 to 79% compared to the unstrengthened slab, and has also provided better stiffness, ductility and energy absorption in the slab system that change the mode of failure from a pure punching shear to flexural failure. The finite element results are compared with the calculated values according to provisions in the current design codes for evaluation purposes. A simple but reliable approach which is based on yield line theory to estimate the flexural capacity of the strengthened slabs is also outlined in this paper.
Design of post‐installed and cast‐in‐place anchors according to the newEN1992‐4 andACI318‐19
Authors: Mahrenholtz Philipp , Wood Richard L. 
Published: August 2020

AbstractPost‐installed and cast‐in‐place anchors are widely used to connect structural or nonstructural elements using a steel baseplate at the concrete structure. Generally, concrete anchors must be qualified if their failure would compromise the safety or result in substantial economic damage. Concrete anchor qualification results in technical approvals forming the basis for a code‐compliant design. In Europe, anchor design is governed by the new standard EN 1992‐4, and in the United States by ACI 318. Qualification and design regulations are predominately similar between Europe and the United States; however, there are still some notable differences. To this end, this paper introduces the basics of anchor design and underlying product qualification. Then, it describes some of the boundary conditions with special attention to the baseplate as well as discusses the critical design parameters. Later, the paper provides a comprehensive overview of the complex design rules. This paper includes identification of the differences between EN 1992‐4 and ACI 318 and their resultant effect on anchor design.
Analytical Average Torque Optimization Method of Parallel Magnetized Surface‐Mounted Permanent‐Magnet Machine with Third‐Order Harmonic Shaping Method
Authors: Hu Pengfei , Wang Dong 
Published: August 2020

AbstractOn the basis of existing studies presented in literature on optimizing permanent magnet (PM) shaping with third harmonic for the tile‐shaped magnetic poles under radial magnetization, this paper proposes a method for PM shape optimization using third harmonic for bread‐shaped magnetic pole under parallel magnetization. Furthermore, the optimal value of third harmonic that should be injected for achieving maximum torque output of a surface‐mounted permanent‐magnet (SPM) motor under parallel magnetization is obtained. The accuracy of the analytical calculation is verified using the finite element method. Furthermore, electromagnetic properties, including back‐EMF waveform, cogging torque, average torque, and torque ripple of the SPM motor obtained under different PM shaping conditions, i.e., without PM shaping, sinusoidal PM shaping, and sinusoidal PM shaping with third harmonic are compared. The comparison results indicate that injecting the optimal value of third harmonic into the PM being subject to sinusoidal shaping can greatly improve the average torque and power density of the SPM motor without increasing the torque ripple. © 2020 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC.
Individual‐level variability among trust criteria relevant to zoos and aquariums
Authors: Dwyer Joseph de la Torre , Fraser John , Voiklis John , Thomas Uduak Grace 
Published: August 2020

AbstractPrior research into the conceptual underpinnings of the public's institutional trust in zoos and aquariums has suggested a range of ethical dimensions that set these types of cultural institutions apart from others in the museum sector. As the recognized holders, care‐takers, and nurturers of wild animals, zoos and aquariums are sustained at least in part by the public's perception that these activities are legitimate pursuits and essential to the long‐term conservation of the natural world. This paper builds on recent research that identified the ethical dimensions of trust in zoos and aquariums and assessed their distribution among the U.S. public by analyzing survey responses with respect to the importance of trust criteria. We hypothesized that distinct clusters of individuals, as defined by their response to trust criteria items, would emerge and that these clusters would prioritize different dimensions in their trust of zoos and aquariums. Using k‐means clustering, we identified four relevant clusters of individuals on seven dimensions of institutional trust in zoos and aquariums. Based on these clusters, we suggest strategies for addressing what may be necessary for zoos and aquariums to claim authority as agents promoting conservation behaviors in society.
Sequenced-based paternity analysis to improve breeding and identify self-incompatibility loci in intermediate wheatgrass (Thinopyrum intermedium)
Authors: Crain Jared , Larson Steve , Dorn Kevin , Hagedorn Traci , DeHaan Lee , Poland Jesse 
Published: August 2020

Abstract
Key Message
Paternity assignment and genome-wide association analyses for fertility were applied to aThinopyrum intermediumbreeding program. A lack of progeny between combinations of parents was associated with loci near self-incompatibility genes.

Abstract
In outcrossing species such as intermediate wheatgrass (IWG, Thinopyrum intermedium), polycrossing is often used to generate novel recombinants through each cycle of selection, but it cannot track pollen-parent pedigrees and it is unknown how self-incompatibility (SI) genes may limit the number of unique crosses obtained. This study investigated the potential of using next-generation sequencing to assign paternity and identify putative SI loci in IWG. Using a reference population of 380 individuals made from controlled crosses of 64 parents, paternity was assigned with 92% agreement using Cervus software. Using this approach, 80% of 4158 progeny (n = 3342) from a polycross of 89 parents were assigned paternity. Of the 89 pollen parents, 82 (92%) were represented with 1633 unique full-sib families representing 42% of all potential crosses. The number of progeny per successful pollen parent ranged from 1 to 123, with number of inflorescences per pollen parent significantly correlated to the number of progeny (r = 0.54, p < 0.001). Shannon’s diversity index, assessing the total number and representation of families, was 7.33 compared to a theoretical maximum of 8.98. To test our hypothesis on the impact of SI genes, a genome-wide association study of the number of progeny observed from the 89 parents identified genetic effects related to non-random mating, including marker loci located near putative SI genes. Paternity testing of polycross progeny can impact future breeding gains by being incorporated in breeding programs to optimize polycross methodology, maintain genetic diversity, and reveal genetic architecture of mating patterns.
Analysis of Metallo-β-lactamases, oprD Mutation, and Multidrug Resistance of β-lactam Antibiotic-Resistant Strains of Pseudomonas aeruginosa Isolated from Southern China
Authors: Li Fei , Chen Danna , Li Lijuan , Liang Dezhi , Wang Fengping , Zhang Bashan 
Published: August 2020

AbstractThe purpose of this study was to analyze the metallo-β-lactamases (MBLs) genotype and oprD mutations of the β-lactam antibiotic-resistant Pseudomonas aeruginosa (PA) strains isolated from southern China. We collected 110 strains of β-lactam antibiotic-resistant PA from 2 hospitals during January 2016–December 2017 from Dongguan, South China. MBLs were detected, amplified, and typed using EDTA disc synergy test, PCR, and Sanger gene sequencing. The mutations and expression levels of oprD were detected using Sanger gene sequencing and qPCR. A total of 16.36% (18/110) β-lactam antibiotic-resistant PA strains produced MBLs, and the main genotypes of MBLs were IMP-25, VIM-2, and SIM-2. Sanger gene sequencing results showed that 107 of the 110 strains harbored mutations in oprD sequence, while 3 strains were negative for oprD amplification (2.73%). Among the 107 strains with positive amplification (97.27%), the rate of intentional mutations (including deletions, insertions, and premature stop codons) was 93.46% (100/107) and that of no disrupted mutation was 6.54% (7/107). qPCR analysis confirmed that the expression level of the OprD protein in the 7 strains of no disrupted mutation was significantly reduced. Among the β-lactam antibiotic-resistant PA strains in southern China, 16.36% were positive for MBLs. The loss rate of oprD was 2.73%, and almost all PA strains showed oprD amplification variation or transcription downregulation. Thus, impaired oprD expression and MBLs production may be some of the mechanisms of β-lactam antibiotic-resistance of PA strains in southern China.
MetaboAge DB: a repository of known ageing-related changes in the human metabolome
Authors: Bucaciuc Mracica Teodora , Anghel Anca , Ion Catalin Florentin , Moraru Corina Violeta , Tacutu Robi , Lazar Gligor Andrei 
Published: August 2020

AbstractAccumulating metabolomics data is starting to become extremely useful in understanding the ageing process, by providing a snapshot into the metabolic state of tissues and organs, at different ages. Molecular studies of such metabolic variations during “normal” ageing can hence guide lifestyle changes and/or medical interventions aimed at improving healthspan and perhaps even lifespan. In this work, we present MetaboAge, a freely accessible database which hosts ageing-related metabolite changes, occurring in healthy individuals. Data is automatically filtered and then manually curated from scientific articles reporting statistically significant associations of human metabolite variations or correlations with ageing. Up to date, MetaboAge contains 408 metabolites annotated with their biological and chemical information, and more than 1515 ageing-related variations, graphically represented on the website grouped by validation methods, sex and age-groups. The MetaboAge database aims to continually structure the expanding information from the field of metabolomics in relation to ageing, thus making it more accessible for further research in gerontology.
Real-world survival outcomes of heavily pretreated patients with refractory HR+, HER2−metastatic breast cancer receiving single-agent chemotherapy—a comparison with MONARCH 1
Authors: Rugo Hope S. , Dieras Veronique , Cortes Javier , Patt Debra , Wildiers Hans , O’Shaughnessy Joyce , Zamora Esther , Yardley Denise A. , Carter Gebra Cuyun , Sheffield Kristin M. , Li Li , Andre Valerie A. M. , Li Xiaohong I. , Frenzel Martin , Huang Yu-Jing , Dickler Maura N. , Tolaney Sara M. 
Published: August 2020

Abstract
Purpose
In MONARCH 1 (NCT02102490), single-agent abemaciclib demonstrated promising efficacy activity and tolerability in a population of heavily pretreated women with refractory HR+, HER2− metastatic breast cancer (MBC). To help interpret these results and put in clinical context, we compared overall survival (OS) and duration of therapy (DoT) between MONARCH 1 and a real-world single-agent chemotherapy cohort.

Methods
The real-world chemotherapy cohort was created from a Flatiron Health electronic health records-derived database based on key eligibility criteria from MONARCH 1. The chemotherapies included in the cohort were single-agent capecitabine, gemcitabine, eribulin, or vinorelbine. Results were adjusted for baseline demographics and clinical differences using Mahalanobis distance matching (primary analysis) and entropy balancing (sensitivity analysis). OS and DoT were analyzed using the Kaplan–Meier method and Cox proportional hazards regression.

Results
A real-world single-agent chemotherapy cohort (n = 281) with eligibility criteria similar to the MONARCH 1 population (n = 132) was identified. The MONARCH 1 (n = 108) cohort was matched to the real-world chemotherapy cohort (n = 108). Median OS was 22.3 months in the abemaciclib arm versus 13.6 months in the matched real-world chemotherapy cohort with an estimated hazard ratio (HR) of 0.54. The median DoT was 4.1 months in MONARCH 1 compared to 2.9 months in the real-world chemotherapy cohort with HR of 0.76.

Conclusions
This study demonstrates an approach to create a real-world chemotherapy cohort suitable to serve as a comparator for trial data. These exploratory results suggest a survival advantage and place the benefit of abemaciclib monotherapy in clinical context.
A Systematic Review of Household and Family Alcohol Use and Adolescent Behavioural Outcomes in Low- and Middle-Income Countries
Authors: Jokinen Tahir , Alexander Emma C. , Manikam Logan , Huq Tausif , Patil Priyanka , Benjumea Darrin , Das Ishani , Davidson Leslie L. 
Published: August 2020

AbstractExposure to alcohol misuse is considered an adverse childhood experience impacting on neurodevelopmental and behavioural outcomes in adolescents including substance use, mental illness, problem behaviours, suicidality, and teenage pregnancy. Most research on this issue has focussed on higher income countries, whereas patterns of alcohol use and related factors may be different in low- and middle-income countries (LMICs). This systematic review therefore seeks to collate all published studies from 1990–2020 on the topic set in LMICs. 43 studies were included, totalling 70,609 participants from 18 LMICs. Outcomes assessed included: substance use; depression/anxiety; suicidal ideation; problem behaviour; emotional dysfunction; teenage pregnancy; and self-harm. Despite heterogeneity in the studies identified, this review documented some association between exposure to household alcohol misuse and adverse adolescent outcomes in LMICs, including mental health problems, problem behaviours, and suicidality. The mechanisms leading to these outcomes are likely varied, and further research in different socio-economic and cultural contexts, particularly in the form of longitudinal studies, is called for.
Bias in natriuretic peptide-guided heart failure trials: time to improve guideline adherence using alternative approaches
Authors: Stienen Susan , Bhatt Ankeet , Ferreira João Pedro , Vaduganathan Muthiah , Januzzi James , Adams Kirkwood , Tardif Jean-Claude , Rossignol Patrick , Zannad Faiez 
Published: August 2020

AbstractTreatment of patients with heart failure with reduced ejection fraction (HFrEF) with currently available therapies reduces morbidity and mortality. However, implementation of these therapies is a problem with only few patients achieving guideline-recommended maximal doses of therapy. In an effort to improve guideline adherence and uptitration, several trials have investigated a biomarker-guided strategy (using natriuretic peptide targets in specific), but although conceptually promising, these trials failed to show a consistent beneficial effect on outcomes. In this review, we discuss different methodological issues that may explain the failure of these trials and offer potential solutions. Moreover, alternative approaches to increase heart failure guideline adherence are evaluated.
Probing conformational transitions towards mutagenic Watson–Crick-like G·T mismatches using off-resonance sugar carbon R1ρ relaxation dispersion
Authors: Rangadurai Atul , Szymanski Eric S. , Kimsey Isaac , Shi Honglue , Al-Hashimi Hashim M. 
Published: August 2020

AbstractNMR off-resonance R1ρ relaxation dispersion measurements on base carbon and nitrogen nuclei have revealed that wobble G·T/U mismatches in DNA and RNA duplexes exist in dynamic equilibrium with short-lived, low-abundance, and mutagenic Watson–Crick-like conformations. As Watson–Crick-like G·T mismatches have base pairing geometries similar to Watson–Crick base pairs, we hypothesized that they would mimic Watson–Crick base pairs with respect to the sugar-backbone conformation as well. Using off-resonance R1ρ measurements targeting the sugar C3′ and C4′ nuclei, a structure survey, and molecular dynamics simulations, we show that wobble G·T mismatches adopt sugar-backbone conformations that deviate from the canonical Watson–Crick conformation and that transitions toward tautomeric and anionic Watson–Crick-like G·T mismatches restore the canonical Watson–Crick sugar-backbone. These measurements also reveal kinetic isotope effects for tautomerization in D2O versus H2O, which provide experimental evidence in support of a transition state involving proton transfer. The results provide additional evidence in support of mutagenic Watson–Crick-like G·T mismatches, help rule out alternative inverted wobble conformations in the case of anionic G·T−, and also establish sugar carbons as new non-exchangeable probes of this exchange process.
Artifacts annotations in anesthesia blood pressure data by man and machine
Authors: Pasma Wietze , Wesselink Esther M. , van Buuren Stef , de Graaff Jurgen C. , van Klei Wilton A. 
Published: August 2020

AbstractPhysiologic data from anesthesia monitors are automatically captured. Yet erroneous data are stored in the process as well. While this is not interfering with clinical care, research can be affected. Researchers should find ways to remove artifacts. The aim of the present study was to compare different artifact annotation strategies, and to assess if a machine learning algorithm is able to accept or reject individual data points. Non-cardiac procedures requiring invasive blood pressure monitoring were eligible. Two trained research assistants observed procedures live for artifacts. The same procedures were also retrospectively annotated for artifacts by a different person. We compared the different ways of artifact identifications and modelled artifacts with three different learning algorithms (lasso restrictive logistic regression, neural network and support vector machine). In 88 surgical procedures including 5711 blood pressure data points, the live observed incidence of artifacts was 2.1% and the retrospective incidence was 2.2%. Comparing retrospective with live annotation revealed a sensitivity of 0.32 and specificity of 0.98. The performance of the learning algorithms which we applied ranged from poor (kappa 0.053) to moderate (kappa 0.651). Manual identification of artifacts yielded different incidences in different situations, which were not comparable. Artifact detection in physiologic data collected during anesthesia could be automated, but the performance of the learning algorithms in the present study remained moderate. Future research should focus on optimization and finding ways to apply them with minimal manual work. The present study underlines the importance of an explicit definition for artifacts in database research.
MiR-21-5p but not miR-1-3p expression is modulated by preconditioning in a rat model of myocardial infarction
Authors: Raupach Annika , Torregroza Carolin , Niestegge Julia , Feige Katharina , Klemm-Meyer Swantje , Bauer Inge , Brandenburger Timo , Grievink Hilbert , Heinen André , Huhn Ragnar 
Published: August 2020

AbstractIsoflurane (Iso) preconditioning (PC) is known to be cardioprotective against ischemia/reperfusion (I/R) injury. It was previously shown that microRNA-21-5p (miR-21-5p) is regulated by Iso-PC. It is unclear, if expression of cardiac enriched miR-1-3p is also affected by Iso-PC, and associated with activation of HIF1α (hypoxia-inducible factor 1-alpha). Male Wistar rats (n = 6–8) were randomly assigned to treatment with or without 1 MAC Iso for 30 min, followed by 25 min of regional myocardial ischemia, with 120 min reperfusion. At the end of reperfusion, myocardial expression of miR-1-3p, miR-21-5p and mRNAs of two HIF-1α-dependent genes, VEGF (vascular endothelial growth factor) and HO-1 (heme oxygenase-1), were determined by quantitative PCR. Protein expression of a miR-21 target gene, PDCD4 (programmed cell death protein 4), was assessed by western blot analysis. Infarct sizes were analyzed with triphenyltetrazoliumchloride staining. MiR-21-5p expression was increased by Iso, whereas expression of miR-1-3p was not altered. The expression of VEGF but not HO-1 was induced by Iso. Iso-PC reduced infarct sizes compared to untreated controls. No regulation of miRNA and mRNA expression was detected after I/R. PDCD4 protein expression was not affected after Iso exposure. Expression of miR-21-5p, in contrast to miR-1-3p, is altered during this early time point of Iso-PC. HIF1α signaling seems to be involved in miR-21-5p regulation.
Evolutionary stability of ambiguity in context signaling games
Authors: Mühlenbernd Roland 
Published: August 2020

AbstractIn Lewisean signaling games with common interests, perfect signaling strategies have been shown to be optimal in terms of communicative success and evolutionary fitness. However, in signaling game models that involve contextual cues, ambiguous signaling strategies can match up to or even outperform perfect signaling. For a minimalist example of such a context signaling game, I will show that three strategy types are expected to emerge under evolutionary dynamics: perfect signaling, partial ambiguity and full ambiguity. Moreover, I will show that partial ambiguity strategies are the most expected outcome and have the greatest basin of attraction among these three types when sender and receiver costs are arbitrarily small or similar. I will demonstrate that the evolutionary success of partial ambiguity is due to being risk dominant, which points to a better compatibility with other strategy types.
Pricing games of NFV infrastructure providers
Authors: Toka Laszlo , Zubor Marton , Korosi Attila , Darzanos George , Rottenstreich Ori , Sonkoly Balazs 
Published: August 2020

AbstractFuture online services will be provisioned over the federation of infrastructure providers for economic reasons: for effective usage of resources and for a wide geographic reach of customers. The technical enablers of this setup, envisioned also for 5G services, are the virtualization techniques applied in data centers, and in access and core networks. Business aspects around the provisioning of these services however pose still unresolved questions. In this heterogeneous setup those who want to deploy an online service face the problem of selecting the compute and network resource set that fulfills the technical requirements of the service deployment and that is preferable also from an economic point of view. Infrastructure providers compete among themselves for these customers, and shape their business offerings with profit maximization in mind. We model this resource market with the tool set of graph and game theory in order to study its characteristics. We show that customers need to tackle a hard problem if they want to meet both their technical and business needs, let alone minimizing costs. Furthermore, we derive the best pricing strategies that the providers should follow given their expectation about customers’ demand. Interestingly, we show that equilibrium prices and the attainable income strongly depend on the provider’s location within the network.