bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Influencing Left Ventricular Ejection Fraction in patients with Coronary Microvascular Disease and Obstructive Coronary Artery Disease
Authors: Mayala Henry Anselmo , Mafuru Magesa , Mkangala Abdalah , Mayala Mark , Pallangyo Pedro , Minja Dickson , Janabi Mohamed , Zhao-hui Wang 
Published: March 2020

Abstract
Objective: The aim of our research was to evaluate the relationship involving Left ventricular ejection fraction, low density lipoprotein, B-type natriuretic peptide, Troponin I and coronary flow reserve, and to determine the predictors of Left ventricular ejection fraction in patients with coronary microvascular disease and Obstructive coronary artery disease, and in patients with coronary microvascular disease.
Results: The mean age was 58.5±12.5 years. In patients with obstructive coronary disease and coronary microvascular disease we found low density lipoprotein-c had significant inverse relationship with left ventricular ejection fraction, left ventricular ejection fraction also had significant negative relationship with B-type natriuretic peptide, and Troponin-I. While a significant direct relationship turned out to be observed linking left ventricular ejection fraction with coronary flow reserve. Left ventricular ejection fraction had significant negative relationship with low density lipoprotein, and B-type natriuretic peptide in patients with Obstructive coronary artery disease only. Age, blood pressure, lipid levels, Red cell distribution width, Glycated hemoglobin, symptoms, New York heart association classification, Alcohol drinking, hypertension, diabetes mellitus, troponin levels and B-type natriuretic peptide were the predictors for left ventricular ejection fraction in coronary microvascular disease patients.
Indonesian adolescents’ perspectives on smoking habits as a reference for a prevention program: a qualitative study
Authors: fithria fithria , Adlim Muhammad , Jannah Syarifah Rauzatul , Tahlil Teuku 
Published: March 2020

Abstract
Background

Religious factors have been used in tobacco control campaigns but due to different perceptions among Muslim scholars that might have an effect on followers, the strategies of control programs are still interesting. Therefore, this qualitative research aimed to explore the perspectives of Muslim adolescents on smoking habits as a reference for developing effective prevention programs.

Methods

Three focus group discussions involving 24 junior high school students (mean age=13.75 years) were the main source of data for this phenomenological qualitative study. The discussion guide was developed by the researchers based on the reviewed literature and validated by experts. The research findings were analyzed using an inductive content method with systematic steps based on the stages of qualitative data analysis.

Results

Adolescent perspectives on smoking were grouped into two themes: (a) perception, which encompassed three sub-themes: smoking as a social habit, contradictive feelings, and the Islamic perspective; (b) smoking-related factors involving peer pressure, the parents’ smoking status, curiosity, and masculinity.

Conclusion

The results indicated that adolescents consider smoking as a social habit but with contradictive feelings. From an Islamic perspective, smoking is not forbidden by the religion’s beliefs. The smoking habit was also stimulated by peer pressure, imitating parents who smoke, curiosity, and feeling masculine. We suggest that health professionals who are interested in developing smoking prevention programs should consider the adolescent perspective on smoking so that the prevention program will be more effective and appropriate for adolescents.
French Stigma Scale: French translation and validation of a stigma scale to measure diabetes-related stigma
Authors: Ouedraogo Johanne , Pana Magnoudewa , Dipankui Mylène Tantchou , Dogba Maman Joyce 
Published: March 2020

Abstract
Context: In recent years internalized stigma, or self-stigma, has been the focus of a number of studies in people living with chronic diseases and mental illness, as it can negatively impact access to care and quality of life. However, few studies have looked at self-stigma experienced by people living with diabetes, specifically among immigrants, a population with a higher risk of stigmatization. Furthermore, the majority of the tools used to measure this type of stigma are only available in English. In order to assess the level of self-stigma among francophone populations living with diabetes, it is imperative to possess a specific French-language tool allowing the measurement of self-stigma in this population. Objective: The aim of this study was to translate and validate a French version of the Self-Stigma Scale-Short (SSS-S), a tool for assessing internalized stigma, in the Canadian immigrant population living with diabetes. Methods: The reliability and validity of the French stigma scale were tested in a sample of 30 immigrant patients living with type 2 diabetes recruited using the volunteer method. Exploratory and confirmatory factor analyses were performed to assess the factors formulated in the original scale, the SSS-S. To evaluate the psychometric properties of the scale, Cronbach's alpha was used to estimate internal consistency and intraclass correlation coefficients were used to assess reliability. Results: The total mean score of the scale obtained for the study sample was 16.57 (± 5.10), showing a low level of stigma. Analysis of the scores indicated good internal consistency (Cronbach’s alpha = 0.86) and excellent reliability (ICC = 0.94) for the full scale. The results of the exploratory factor analysis confirmed the original three-dimensional structure of the SSS-S, despite an unsatisfactory confirmatory factor analysis. (Pr > chi-squared of the base model < 0.05, RMSEA > 0.06, for both models). Conclusion: The French stigma scale is a valid and reliable tool that can be used to assess internalized stigma in patients living with diabetes.
Co-expression network analysis of the genes associated with pistillody-stamen development in wheat
Authors: Liao Mingli , Chen Zhenyong , Yang Zaijun , Chen Weiying , Wei Shuhong , Peng Zhengsong 
Published: March 2020

Abstract
Background: Crop male sterility has great values in both theoretical research and breeding application. Wheat pistillody-stamen is an important male sterility phenomenon, and HTS-1 is an important pistillody-stamen material. However the molecular mechanism of HTS-1 stamens transformed into pistils or pistil-like structures remains a mystery. Weighted gene co-expression network analysis (WGCNA) are widely used to explore hub genes and gene interaction networks from high throughput data in various plants. Results: In the present study, for exploring gene networks associated with wheat pistillody-stamen development, WGCNA was employed to analyze 11 RNA-sequencing (RNA-seq) data of wheat tissues, including stamens of CSTP, pistils and pistillody-stamen of HTS-1. 19 out of 25 merged modules were highly associated with specific wheat tissues, and the MEdarkseagreen1 module was highly related to wheat pistillody-stamen (correlation with weight r =0.7, correlation p-value p =0.02). Then 180 genes about wheat flower development were identified from the MEdarkseagreen1 module by GO term analysis. Among 180 genes, the hub gene number associated with anther, filament, style, and ovary development were 12, 3, 3, and 10, respectively. We compared the published pistillody related proteins with proteins of HTS-1 by BLAST. A total of 58 pistillody-stamen development associated proteins were validated by BLAST. MADS-box and YABBY transcription factor about pistillody-stamen development were also analyzed in wheat flower. There were 47 of MADS-box and 17 of YABBY transcription factors were identified. BLAST program was used to align the published pistillody associated MADS-box and YABBY transcription factors with transcription factors identified in wheat flower. Totally, 36 of 47 MADS-box and 14 of 17 YABBY transcription factors were considered to regulate the development of pistillody-stamen, which had never been reported yet. Conclusion: These results have systematically identified the key candidate genes about the development of HTS-1 substructures flower. The tissue-specific correlation network analyses provide important insights into the molecular interactions underlying psitillody-stamen development.
How many digits after decimal point are needed to use SUVmax as an identifier of tumors on FDG PET-CT?
Authors: Hirata Kenji , Manabe Osamu , Magota Keiichi , Furuya Sho , Shiga Tohru , Kudo Kohsuke 
Published: March 2020

Abstract
PurposeThe maximum standardized uptake value (SUVmax) is often described in daily clinical reports of FDG PET-CT. We investigated whether it would be possible to localize the voxel automatically based on the SUVmax.MethodsThe institutional review board approved this retrospective study. We investigated a total of 112 lesions from 30 FDG PET-CT images acquired with 3 different scanners. The number of voxels showing the given SUVmax was counted, where SUVmax was provided with various degrees of precision, such as 3, 3.1, 3.14, 3.142. The effects of local maximum restriction, where only local maximum voxels were chosen, were evaluated.ResultsSUVmax ranged from 1.3 to 49.1 (median = 5.6, IQR = 5.2). Generally, when larger and more precise SUVmax values were given, fewer voxels were included in the range. The local maximum restriction was very effective. When SUVmax was determined to 4 decimal places (e.g., 3.1416) and the local maximum restriction was applied, 33.3% (lesions with SUVmax<2), 79.5% (2≤SUVmax<5), and 97.8% of lesions (5≤SUVmax) were successfully identified (i.e., only a single voxel satisfied the criteria).ConclusionsIn FDG PET-CT, SUVmax can be used to localize the lesion if a large and precise SUVmax is provided.
Appropriateness Use Criteria of Trans-Thoracic 2D-Echocardiography Among Adult Patients in the Philippine General Hospital
Authors: Villanueva Danielle Louis , Patricio Marion , Magno Jose Donato , Punzalan Felix Eduardo 
Published: March 2020

Abstract
BACKGROUND There is an increasing utilization rate and clinical importance of performing echocardiography especially in a tertiary referral center such as the UP-PGH. An appropriate use criteria (AUC) in echocardiography is essential to improve clinical outcomes while preserving hospital and patient resources. METHODS We reviewed the echocardiographic requests of patients referred for transthoracic 2d-echocardiography. Echocardiography indication were documented mainly using the echocardiography order/request form. The echocardiography indications were adjudicated by at least two investigators. If there was more than one indication that fit into the AUC 2011, the most appropriate one was retained. RESULTS A total of 1006 echocardiographic requests were included in this study. The patients were predominantly males (68.2%) and with a mean age of 56.27 ± 16.89. majority of the referrals came from the medicine wards (37.3%). The top three cardiac diagnosis are: Heart Failure (25.9%), Acute Coronary Syndrome (20.7%) and Hypertension (15.5%). Of the top 15 most common indications, 11 were appropriate while 2 were maybe appropriate, and 2 were rarely appropriate. The three most common specific indication is the evaluation for heart failure (21.4%), the search for a cardiac etiology for a particular symptom (14.3%) and the initial evaluation of a suspected hypertensive heart disease (9.9%). The most common rarely appropriate indication is the routine perioperative evaluation of ventricular function (5.5%). Majority of the echocardiography requests have appropriate indications (87.9%). CONCLUSION This is the first application of the AUC to the transthoracic 2d-echo here in the Philippines. The transthoracic 2D-echocardiography done in the Philippine General Hospital have mostly appropriate indications.
Assessing the role of two populations of Aedes japonicus japonicus for Zika virus transmission under a constant and a fluctuating temperature regime.
Authors: Glavinic Uros , Varga Jasmin , Paslaru Anca Iona , Hauri Jeannine , Torgerson Paul , Schaffner Francis , Veronesi Eva 
Published: March 2020

Abstract
Background Since the huge epidemic of Zika virus (ZIKV) in Brazil in 2015, questions were raised to understand which mosquito species could transmit the virus. Although Aedes aegypti has been described as the main vector, other Aedes species (e.g. Ae. albopictus and Ae. japonicus) which can potentially transmit viruses from the same family (Flavivirus) such as West Nile, dengue and yellow fever, at least under laboratory conditions, have been incriminated as potential vector for ZIKV. Among these, the Asian bush mosquito Ae. japonicus is widely spread with high abundances in Central-Western Europe. In the present study, infection, dissemination and transmission rates of ZIKV (Dak84 strain) in two populations of Ae. japonicus from Switzerland (Zürich) and France (Steinbach, Haut-Rhin) were investigated under constant (27 °C) and fluctuating (14-27 °C, mean 23 °C) temperature regimes.Results Both populations were positive for ZIKV transmission. Infectious virus particles were present already 7 days post exposure to infectious rabbit blood. The highest amount of Plaque Forming Unit (PFU) (400/female) were recorded 14 days post oral infection in the Swiss population incubated at constant temperature. No difference in term of infection, dissemination and transmission rate were found according to the mosquito population.Temperature had no effect on infection rate but the fluctuating temperature regime resulted in higher dissemination rates comparing to constant temperature, regardless of the population. Finally, transmission efficiency ranged between 7-23% and 7-10% for the constant temperature and 0-10% and 3-27% under fluctuating temperatures for the Swiss and the French populations, respectively.Conclusions This is the first work confirming vector competence for ZIKV of Ae. japonicus originating from Switzerland and France under realistic summer temperatures. Considering the continuous spread of this species in the northern part of Europe and its adaptation at cooler temperatures, preventative control measures should be adopted to prevent possible ZIKV epidemics.
­­­Opportunities for gender transformative approaches in a community-based drowning reduction program in Bangladesh
Authors: Gupta Medhavi , Rahman Aminur , Dutta NC , Nambiar Devaki , Ivers Rebecca , Jagnoor Jagnoor 
Published: March 2020

Abstract
Background: Community-based programs in rural low-and middle-income country settings are well-placed to conduct gender transformative activities that aid program sustainability and catalyse wider social change, such as reducing gender inequities that in turn improve health outcomes. The Anchal program is a drowning prevention intervention for children aged 1-5 years old in rural Bangladesh. It provides community crèche-based supervision delivered by local trained paid-female volunteers. We aimed to identify the impact of the Anchal program on gender norms and behaviours in the community context, and the effects these had on program delivery and men and women’s outcomes. Methods: Qualitative in-depth interviews, focus group discussions and observations were conducted with program beneficiaries and providers. Gender impacts and outcomes were analysed using FHI 360’s Gender Integration Framework. Results: The Anchal program was found to be a gender accommodating program as it catered for communities’ gender-based roles and constraints but did not actively seek to change underlying beliefs, perceptions and norms that led to these. The program in some cases enhanced the independence and status of female community staff. This changed perceptions of communities towards acceptable levels of physical mobility and community involvement for women. Conversely, gender impacted program delivery by reducing the ability of female supervisory staff to engage with male community leaders. The double burden of wage and household labour carried by local female staff also limited performance and progression. Gender-based constraints on staff performance, attrition and community engagement affected efficiency of program delivery and sustainability. Conclusions: The Anchal program both adapted to and shaped community gender norms and roles. The program has well-established relationships in the community and can be leveraged to implement gender transformative activities to improve gender-based equity. Health programs can broaden their impacts and target social determinants of health like gender equity to increase program sustainability and promote equitable health outcomes.
Trends of multimorbidity in 15 European countries: a population-based study in community-dwelling adults aged 50 and over
Authors: Roig Javier Jerez , Souza Dyego L. B. , Oliveras-Fabregas Albert , Minobes-Molina Eduard , Cancela Marianna de Camargo , Galbany-Estragués Paola 
Published: March 2020

Abstract
Background: The objective of this work was to analyse the prevalence trends of multimorbidity among European community-dwelling adults.Methods: A temporal series study based on waves 1, 2, 4, 5, 6 and 7 of the Survey of Health, Ageing and Retirement in Europe (SHARE) was conducted, and community-dwelling participants aged 50+ (n=274,614) from 15 European countries were selected, for the period 2004-2017. Prevalence, adjusted by age, Annual Percentage Change (APC) and 95% confidence interval (95% CI) were all calculated. Trend analyses were realised by period, age groups and groups of diseases. Results: The results showed a large variability in the prevalence of multimorbidity in adults aged 50 and over among European countries. Increase in the prevalence of multimorbidity in the countries of central Europe (Austria, Belgium, Czech Republic, France, Germany and Switzerland) and Spain in both sexes, and in the Netherlands among men. Stability was observed in northern and eastern European countries. Musculoskeletal and neurodegenerative groups showed more significant changes in the trend analyses. Conclusions: This information can be useful for policy makers when planning health promotion and prevention policies addressing modifiable risk factors in health.
A nomogram model to predict death rate among non-small cell lung cancer (NSCLC) patients with surgery in Surveillance, Epidemiology, and End Results (SEER) database
Authors: Jia Bo , Zheng Qiwen , Wang Jingjing , Sun Hongyan , Zhao Jun , Wu Meina , An Tongtong , Wang Yuyan , Zhuo Minglei , Li Jianjie , Yang Xue , Zhong Jia , Chen Hanxiao , Chi Yujia , Zhai Xiaoyu , wang ziping 
Published: March 2020

Abstract
Background This study aimed to establish a novel nomogram prognostic model to predict death probability for non-small cell lung cancer (NSCLC) patients who received surgery. Methods We collected data from the Surveillance, Epidemiology, and End Results (SEER) database of the National Cancer Institute in the United States. A nomogram prognostic model was constructed to predict mortality of NSCLC patients who received surgery. Results A total of 44,880 NSCLC patients who received surgery from 2004 to 2014 were included in this study. Gender, race, tumor anatomic sites, histologic subtype, tumor differentiation, clinical stage, tumor size, tumor extent, lymph node stage, examined lymph node, positive lymph node, type of surgery showed significant associations with lung cancer related death rate (P<0.001). Patients who received chemotherapy and radiotherapy had significant higher lung cancer related death rate but were associated with significant lower non-cancer related mortality (P<0.001). A nomogram model was established based on multivariate models of training data set. In the validation cohort, the unadjusted C-index was 0.73 (95% CI, 0.72-0.74), 0.71 (95% CI, 0.66-0.75) and 0.69 (95% CI, 0.68-0.70) for lung cancer related death, other cancer related death and non-cancer related death. Conclusions A prognostic nomogram model was constructed to predict death rate for NSCLC patients who received surgery. This novel prognostic model may be helpful for physicians to develop the most appropriate treatment strategies for resected NSCLC patients. Parts of these results were presented at the 2018 American Society of Clinical Oncology Annual Meeting (Abstract #8525)
Intraductal papillary mucinous neoplasm of the intrahepatic bile ducts: a case report and literature review
Authors: jia fan , Zhang Ying , Zhang Ling-Qiang , Wang Yu-Le , Liu Yan , Ma Xiao-Lei , Chen Gong-Fu , Ren Bin , Guo Xin-Jian , Jia Guo-Bing , Yangdan Cai-Rang 
Published: March 2020

Abstract
Background: Intraductal papillary mucinous neoplasm of the bile ducts (IPMN-B) is a rare malignant tumor originated from the epithelium of the bile duct. It can secrete a large amount of mucin to cause biliary obstruction. This disease has just been recognized in recent years.Case presentation: We found a 60-year-old woman with intermittent right upper abdominal pain. Imaging examination showed that the left intrahepatic bile duct was dilated with a solid mass. We had left hepatectomy. During the operation, there was colloidal mucus in the bile duct. There was a papillary mass on the wall of the bile duct. -to have developed into invasive adenocarcinoma. At a postoperative 6 months follow-up, the patient had no recurrence and is in good conditions. Conclusion: In our case, IPMN-B has underwent a malignant transformation at the early stage. Therefore, we think that surgical resection should be done as early as possible after the diagnosis of IPMN-B, so as to get a favorable prognosis.
Extended-field intensity-modulated radiotherapy and dosage boost for lymph node metastasis are beneficial for the prognosis of FIGO IIICr and IVA cervical cancer patients with positive regional lymph nodes
Authors: Zhao Yuhua , Li Gong , Gao Lei 
Published: March 2020

Abstract
Background: This study aimed to evaluate the therapeutic efficacy of extended-field intensity-modulated radiotherapy (EF-IMRT) and dosage boost for positive lymph nodes, prognostic factors, treatment failure, and toxicity for Federation of Gynecology and Obstetrics (FIGO) stage IIICr and IVA cervical cancer patients with positive regional lymph nodes.Methods: We retrospectively evaluated 34 patients with stage IIICr and IVA who had received treatment in our institute between 2013 and 2016. Patients with stage IVA cervical cancer who had been enrolled in the analysis all had positive regional lymph nodes (pelvic or/and para-aortic). All 34 patients were treated with EF-IMRT and simultaneously integrated boost-IMRT (SIB-IMRT) for lymph node metastasis with concurrent chemotherapy and brachytherapy. Positive regional lymph nodes (short-axis diameter ≥5 mm in computed tomography [CT] or magnetic resonance imaging [MRI]) remaining after SIB-IMRT were then treated with sequential boost-IMRT (SeB-IMRT). The prognostic factors for overall survival (OS); disease-free survival (DFS); local control rate (LCR); regional control rate (RCR); distant metastasis-free survival (DMFS), including age, FIGO stage, pretreatment hemoglobin (HB) level, tumor size, para-aortic lymph node (PALN) metastasis, point A equivalent dose in 2-Gy fractions (EQD2 dose), concurrent chemotherapy, and adjuvant chemotherapy cycles, were analyzed.Results: Complete response (CR) was achieved in 31 (91.2%) patients with acceptable adverse effects. Notably, the three-year OS, DFS, LCR, RCR, DMFS for these patients were 73.5%, 70.6%, 88.1%, 87.9%, and 81.6%, respectively. In particular, the three-year OS, DFS, LCR, RCR, and DMFS of patients with positive PALNs was 41.7%, 33.3%, 65.6%, 72.2%, and 60.2%, respectively. The corresponding values in patients without positive PALNs were 90.9%, 90.9%, 100%, 95.5%, and 90.9%, respectively.Conclusions: Our study suggested that the EF-IMRT and nodal dosage boost decreased regional node failure and that patients with stage IIIC1r and IVA cervical cancer without PALN metastasis who received EF-IMRT and SIB-IMRT with or without SeB-IMRT had a significant survival advantage in terms of the DFS and OS.