bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful thrombolytic therapy with recombinant tissue plasminogen activator in ischemic stroke after idarucizumab administration for reversal of dabigatran: a case report
Authors: Ohtani Toshiyuki , Sintoku Ryosuke , Yajima Tasuku , Kaneko Naoyuki 
Published: December 2019

Abstract
Background
Idarucizumab is a specific antidote for the anticoagulant dabigatran. Although its efficacy has been recently reported, the drug is still in postmarketing surveillance and requires case data in different emergency settings. A newer intravenous thrombolytic therapy with recombinant tissue plasminogen activator has been proposed after injection of idarucizumab in patients receiving dabigatran; however, the safety and efficacy of this therapy are equivocal because of the limited number of reported cases. We describe a case of a patient with acute lacunar stroke causing dysarthria and hemiparesis successfully treated with intravenous thrombolytic therapy with recombinant tissue plasminogen activator after reversal of dabigatran with idarucizumab.

Case presentation
A 67-year-old Asian woman was transferred to our emergency center 200 minutes after sudden onset of dysarthria and right-sided hemiparesis. She had been taking dabigatran for prevention of stroke recurrence caused by atrial fibrillation. Diffusion-weighted magnetic resonance imaging revealed a new lacunar infarction near old putamen infarctions. We treated her with intravenous thrombolytic therapy with recombinant tissue plasminogen activator after administering idarucizumab. The time to recombinant tissue plasminogen activator administration was 5 minutes from idarucizumab injection and 269 minutes from symptom onset. The patient’s activated partial thromboplastin times were 68.0 and 43.2 seconds before and after the therapy, respectively. The patient’s neurological symptoms improved significantly after the treatment, and she experienced no adverse events.

Conclusions
Intravenous thrombolytic therapy with recombinant tissue plasminogen activator after reversal of dabigatran with idarucizumab may be safe and feasible in patients with acute ischemic stroke with lacunar infarct. Furthermore, intravenous thrombolytic therapy with recombinant tissue plasminogen activator could be used in patients in emergency settings until just before the end of the recommended time limit within which it needs to be administered because of the immediate effect of idarucizumab.
Control plane delay minimization-based capacitated controller placement algorithm for SDN
Authors: Chai Rong , Yuan Qiongfang , Zhu Lei , Chen Qianbin 
Published: December 2019

AbstractSoftware-defined networking (SDN) is proposed as a new network paradigm which decouples control plane from data plane and provides flexible network management. In this paper, we consider the capacitated controller placement problem in SDN, which jointly determines the number, location, and the capacity matching strategy of SDN controllers. redTo stress the importance of control plane delay which is composed of both the transmission and processing delay between controllers and switches, and the inter-controller delay; we formulate control plane delay minimization problem subject to controller-switch association constraints, controller capacity constraints, etc. Since the formulated optimization problem is a complicated nonlinear integer programming problem which cannot be solved easily, we transform it into controller-switch association subproblem and controller capacity matching subproblem. To solve the controller-switch association subproblem, we propose a heuristic algorithm based on Dijkstra algorithm and K-means algorithm. Given the controller-switch association strategy, we then apply the Kuhn-Munkres (K-M) algorithm to solve the controller capacity matching subproblem and obtain the capacitated controller placement strategy. Simulation results are shown to demonstrate the effectiveness of the proposed algorithm.
Security governance as a service on the cloud
Authors: Bryce Ciarán 
Published: December 2019

AbstractSmall companies need help to detect and to respond to increasing security related threats. This paper presents a cloud service that automates processes that make checks for such threats, implement mitigating procedures, and generally instructs client companies on the steps to take. For instance, a process that automates the search for leaked credentials on the Dark Web will, in the event of a leak, trigger processes that instruct the client on how to change passwords and perhaps a micro-learning process on credential management. The security governance service runs on the cloud as it needs to be managed by a security expert and because it should run on an infrastructure separated from clients. It also runs as a cloud service for economy of scale: the processes it runs can service many clients simultaneously, since many threats are common to all. We also examine how the service may be used to prove to independent auditors (e.g., cyber-insurance agents) that a company is taking the necessary steps to implement its security obligations.
Serum histone H3 levels and platelet counts are potential markers for coagulopathy with high risk of death in septic patients: a single-center observational study
Authors: Ito Takashi , Totoki Takaaki , Yokoyama Yayoi , Yasuda Tomotsugu , Furubeppu Hiroaki , Yamada Shingo , Maruyama Ikuro , Kakihana Yasuyuki 
Published: December 2019

Abstract
Background
Recent studies have suggested that anticoagulant therapy does not confer a survival benefit overall in sepsis, but might be beneficial in sepsis-associated disseminated intravascular coagulation (DIC). In particular, those with high Sequential Organ Failure Assessment (SOFA) scores might be the optimal target for anticoagulant therapy. However, both DIC and SOFA scores require the measurement of multiple markers. The purpose of this study was to explore a minimal marker set for determining coagulopathy at high risk of death in septic patients, wherein histone H3 levels were evaluated as indicators of both organ failure and coagulation activation.

Methods
We analyzed correlations among levels of serum histone H3 and other coagulation markers in 85 cases of sepsis using Spearman’s rank correlation test. We then compared the utility of histone H3 to that of other coagulation markers in predicting the traditional DIC state or 28-day mortality by receiver-operating characteristics analysis. Finally, we suggested cut-off values for determining coagulopathy with high risk of death, and evaluated their prognostic utility.

Results
Serum histone H3 levels significantly correlated with thrombin-antithrombin complex (TAT) levels (Spearman’s ρ = 0.46, p < 0.001), and weakly correlated with platelet counts (Spearman’s ρ = − 0.26, p < 0.05). Compared to other coagulation markers, histone H3 levels showed better performance in predicting 28-day mortality. When combining serum histone H3 levels with platelet counts, our new scoring system showed a concordance rate of 69% with the traditional four-factor criteria of DIC established by the Japanese Association for Acute Medicine. The 28-day mortality rates of the new and the traditional criteria-positive patients were 43% and 21%, respectively. Those of the new and the traditional criteria-negative patients were 5.7% and 9.4%, respectively.

Conclusions
Serum histone H3 levels and platelet counts are potential markers for determining coagulopathy with high risk of death in septic patients. Further studies are needed to clarify the utility of serum histone H3 levels in the diagnostic of coagulopathy/DIC.
Fault model of the 2012 doublet earthquake, near the up-dip end of the 2011 Tohoku-Oki earthquake, based on a near-field tsunami: implications for intraplate stress state
Authors: Kubota Tatsuya , Hino Ryota , Inazu Daisuke , Suzuki Syuichi 
Published: December 2019

AbstractOn December 7, 2012, an earthquake occurred within the Pacific Plate near the Japan Trench, which was composed of deep reverse- and shallow normal-faulting subevents (Mw 7.2 and 7.1, respectively) with a time interval of ~10 s. It had been known that the stress state within the plate was characterized by shallow tensile and deep horizontal compressional stresses due to the bending of the plate (bending stress). This study estimates the fault model of the doublet earthquake utilizing tsunami, teleseismic, and aftershock data and discusses the stress state within the incoming plate and spatiotemporal changes seen in it after the 2011 Tohoku-Oki earthquake. We obtained the vertical extents of the fault planes of deep and shallow subevents as ~45–70 km and ~5 (the seafloor)–35 km, respectively. The down-dip edge of the shallow normal-faulting seismic zone (~30–35 km) deepened significantly compared to what it was in 2007 (~25 km). However, a quantitative comparison of the brittle strength and bending stress suggested that the change in stress after the Tohoku-Oki earthquake was too small to deepen the down-dip end of the seismicity by ~10 km. To explain the seismicity that occurred at a depth of ~30–35 km, the frictional coefficient in the normal-faulting depth range required would have had to be ~0.07 ≤μ≤ ~0.2, which is significantly smaller than the typical friction coefficient. This suggests the infiltration of pore fluid along the bending faults, down to ~30–35 km. It is considered that the plate had already yielded to a depth of ~35 km before 2011 and that the seismicity of the area was reactivated by the increase in stress from the Tohoku-Oki earthquake.
Full command of a network by a new node: some results and examples
Authors: Grácio Clara , Fernandes Sara , Lopes Luís Mário 
Published: December 2019

AbstractWe consider that a network of chaotic identical dynamical systems is connected to a new node. Depending on some properties of the network and on the way that connection is made, the new node may control the network. We consider a full-command connection and analyze the possibility of the network being full-commandable by the new node. For full-commandable networks, we define the full-command-window, a set that includes some of the values that the coupling strength of the new node may assume. We present several results and examples that enlight us how a network can become more vulnerable or resistant to full-command.
Neutralization of interleukin-17A alleviates burn-induced intestinal barrier disruption via reducing pro-inflammatory cytokines in a mouse model
Authors: Song Yajun , Li Yang , Xiao Ya , Hu Wengang , Wang Xu , Wang Pei , Zhang Xiaorong , Yang Jiacai , Huang Yong , He Weifeng , Huang Chibing 
Published: December 2019

Abstract

Background
The intestinal barrier integrity can be disrupted due to burn injury, which is responsible for local and systemic inflammatory responses. Anti-inflammation strategy is one of the proposed therapeutic approaches to control inflammatory cascade at an early stage. Interleukin-17A (IL-17A) plays a critical role in inflammatory diseases. However, the role of IL-17A in the progression of burn-induced intestinal inflammation is poorly understood. In this study, we aimed to investigate the effect of IL-17A and associated pro-inflammatory cytokines that were deeply involved in the pathogenesis of burn-induced intestinal inflammatory injury, and furthermore, we sought to determine the early source of IL-17A in the intestine.

Methods
Mouse burn model was successfully established with infliction of 30% total body surface area scald burn. The histopathological manifestation, intestinal permeability, zonula occludens-1 expression, pro-inflammatory cytokines were determined with or without IL-17A-neutralization. Flow cytometry was used to detect the major source of IL-17A+ cells in the intestine.

Results
Burn caused intestinal barrier damage, increase of intestinal permeability, alteration of zonula occludens-1 expressions, elevation of IL-17A, IL-6, IL-1β and tumor necrosis factor-α (TNF-α), whereas IL-17A neutralization dramatically alleviated burn-induced intestinal barrier disruption, maintained zonula occludens-1 expression, and noticeably, inhibited pro-inflammatory cytokines elevation. In addition, we observed that the proportion of intestinal IL-17A+Vγ4+ T subtype cells (but not IL-17A+Vγ1+ T subtype cells) were increased in burn group, and neutralization of IL-17A suppressed this increase.

Conclusions
The main original findings of this study are intestinal mucosa barrier is disrupted after burn through affecting the expression of pro-inflammatory cytokines, and a protective role of IL-17A neutralization for intestinal mucosa barrier is determined. Furthermore, Vγ4+ T cells are identified as the major early producers of IL-17A that orchestrate an inflammatory response in the burn model. These data suggest that IL-17A blockage may provide a unique target for therapeutic intervention to treat intestinal insult after burn.
Mesenchymal stromal cells-exosomes: a promising cell-free therapeutic tool for wound healing and cutaneous regeneration
Authors: Hu Peng , Yang Qinxin , Wang Qi , Shi Chenshuo , Wang Dali , Armato Ubaldo , Prà Ilaria Dal , Chiarini Anna 
Published: December 2019

Abstact
Cutaneous regeneration at the wound site involves several intricate and dynamic processes which require a series of coordinated interactions implicating various cell types, growth factors, extracellular matrix (ECM), nerves, and blood vessels. Mesenchymal stromal cells (MSCs) take part in all the skin wound healing stages playing active and beneficial roles in animal models and humans. Exosomes, which are among the key products MSCs release, mimic the effects of parental MSCs. They can shuttle various effector proteins, messenger RNA (mRNA) and microRNAs (miRNAs) to modulate the activity of recipient cells, playing important roles in wound healing. Moreover, using exosomes avoids many risks associated with cell transplantation. Therefore, as a novel type of cell-free therapy, MSC-exosome -mediated administration may be safer and more efficient than whole cell. In this review, we provide a comprehensive understanding of the latest studies and observations on the role of MSC-exosome therapy in wound healing and cutaneous regeneration. In addition, we address the hypothesis of MSCs microenvironment extracellular vesicles (MSCs-MEVs) or MSCs microenvironment exosomes (MSCs-MExos) that need to take stock of and solved urgently in the related research about MSC-exosomes therapeutic applications. This review can inspire investigators to explore new research directions of MSC-exosome therapy in cutaneous repair and regeneration.
Coordinated control of conventional power sources and PHEVs using jaya algorithm optimized PID controller for frequency control of a renewable penetrated power system
Authors: Annamraju Anil , Nandiraju Srikanth 
Published: December 2019

AbstractIn renewable penetrated power systems, frequency instability arises due to the volatile nature of renewable energy sources (RES) and load disturbances. The traditional load frequency control (LFC) strategy from conventional power sources (CPS) alone unable to control the frequency deviations caused by the aforementioned disturbances. Therefore, it is essential to modify the structure of LFC, to handle the disturbances caused by the RES and load. With regards to the above problem, this work proposes a novel coordinated LFC strategy with modified control signal to have Plug-in Hybrid Electric Vehicles (PHEVs) for frequency stability enhancement of the Japanese power system. Where, the coordinated control strategy is based on the PID controller, which is optimally tuned by the recently developed JAYA Algorithm (JA). Numerous simulations are performed with the proposed methodology and, the results have confirmed the effectiveness of a proposed approach over some recent and well-known techniques in literature. Furthermore, simulation results reveal that the proposed coordinated approach significantly minimizing the frequency deviations compared to the JAYA optimized LFC without PHEVs & with PHEVs but no coordination.
Learning capacity: predicting user decisions for vehicle-to-grid services
Authors: Shipman Rob , Naylor Sophie , Pinchin James , Gough Rebecca , Gillott Mark 
Published: December 2019

AbstractThe electric vehicles (EV) market is projected to continue its rapid growth, which will profoundly impact the demand on the electricity network requiring costly network reinforcements unless EV charging is properly managed. However, as well as importing electricity from the grid, EVs also have the potential to export electricity through vehicle-to-grid (V2G) technology, which can help balance supply and demand and stabilise the grid through participation in flexibility markets. Such a scenario requires a population of EVs to be pooled to provide a larger storage resource. Key to doing so effectively however is knowledge of the users, as they ultimately determine the availability of a vehicle. In this paper we introduce a machine learning model that aims to learn both a) the criteria influencing users when they decided whether to make their vehicle available and b) their reliability in following through on those decisions, with a view to more accurately predicting total available capacity from the pool of vehicles at a given time. Using a series of simplified simulations, we demonstrate that the learning model is able to adapt to both these factors, which allows the required capacity of a market event to be satisfied more reliably and using a smaller number of vehicles than would otherwise be the case. This in turn has the potential to support participation in larger and more numerous market events for the same user base and use of the technology for smaller groups of users such as individual communities.
Analysis of the cannabinoid content of strains available in the New Jersey Medicinal Marijuana Program
Authors: Coogan Thomas A. 
Published: December 2019

AbstractBackgroundThe six licensed operators in the New Jersey Medicinal Marijuana Program submit their strains of cannabis flower to a single laboratory, administered by the state’s Department of Health, for testing. The results of these tests are made available by the State on a web page for patients, allowing a study of the range of cannabinoid profiles available in the program.MethodsReports on cannabinoid concentrations were collected from 245 test reports released by the State lab; the relative quantities of cannabinoids on all strains was evaluated, as well as trends in the strain types being tested.ResultsThe collection of strain profiles available in New Jersey conforms to results of other population studies, revealing three broad classification of strains based on their relative concentration of cannabinoids: the overwhelmingly majority of strains contain only trace (< 1%) CBDA but high THCA concentration; a handful are balanced in CBDA and THCA content; and a very few strains have a high concentration of CBDA and minimal THCA (< 1%). In those strains that contain more than 1% of both THCA and CBDA, those two substances are present in comparable quantities. The concentration of CBGA is higher in those strains that have the highest THCA concentration, though there are strains that have high THCA (> 20%) with CBGA concentrations at the low end of the range (< 0.5%). In the high CBD strains, the concentration of CBGA is positively correlated with CBDA, but the CBGA concentrations are several fold less in CBD-dominant strains than in THC-dominant strains: the highest measured CBGA concentration in a CBD-dominant strain is only at the average value of CBGA concentration in THC-dominant strains. The most-recently tested strains are overwhelmingly of the THC-dominant type.ConclusionsThough some high CBD strains are available in the New Jersey medical marijuana program, the vast majority of strains that have been tested are the THC-dominant strains which contain less than 1% CBDA. The data available from the State does not include any information on how well the different strains sell, but it can be inferred from the trend in strain types tested that the demand in the New Jersey medical market is for THC-dominant strains.
Effect of irrigation water containing arsenic on elemental composition of bean and lettuce plants cultivated in calcareous sandy soil
Authors: Sandil Sirat , Dobosy Péter , Kröpfl Krisztina , Füzy Anna , Óvári Mihály , Záray Gyula 
Published: December 2019

Abstract
Background
The uptake of arsenic by vegetables from soil irrigated with arsenic enriched groundwater poses a major health hazard. The edible portion of these vegetables transfer arsenic to the human beings. The uptake of arsenic was studied in bean (Phaseolus vulgaris L.) and lettuce (Lactuca sativa L.) in a controlled greenhouse pot culture with calcareous sandy soil as substrate. The plants were irrigated with water containing sodium arsenate at concentrations 0.1, 0.25 and 0.5 mg L− 1. The total arsenic concentration of the different plants parts was determined by ICP-MS, following microwave-assisted acid digestion. The change in plant biomass production and essential macroelements (Mg, P, K) and microelements concentration (Fe, Mn, Cu, Zn) was also studied.

Results
The As concentration in the bean was in the order: root>stem>leaf>bean fruit and in lettuce: root>leaves. At the highest dose (0.5 mg L− 1) the As concentration in the bean fruit and lettuce leaves was 22.1 μg kg− 1 and 1207.5 μg kg− 1 DW, respectively. Increasing As concentration in the irrigation water resulted in decreased edible biomass production in bean, while in lettuce the edible biomass production increased. Neither plant exhibited any visible toxicity symptoms. No significant change was observed in the macro and microelements concentration. The total and the water-soluble arsenic in soil amounted to 3.5 mg kg− 1 and 0.023 mg kg− 1, respectively. The transfer factor was found to increase with increase in the As treatment applied. The transfer factor range for bean from root to fruit was 0.003–0.005, and for lettuce from root to leaves was 0.14–0.24.

Conclusion
Considering the FAO-WHO recommended maximum tolerable daily intake (MTDI) limit of 2.1 μg kg− 1 body weight, and the biomass production, both plants should not be cultivated at As treatment level higher than 0.1 mg L− 1.

Graphical abstract