bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of trypsin protected CsPbCl3 fluorescent nanocrystals for hydroxyl radical sensing
Authors: Kailasa Suresh Kumar , Makwana Kartik Pankajbhai , Deshpande Madhura Pradeep , Choi Yoojin , Park Tae Jung 
Published: December 2024

Abstract

Water-dispersible perovskite nanocrystals (PNCs) show promising applications in recognizing ionic and molecular species because of their excellent optical properties. However, lead halide PNCs have some limitations when they are used as probes for molecular species sensing in aqueous media. Here, we introduce trypsin (Try) as a bioligand for the synthesis of cesium lead chloride (CsPbCl3) perovskite nanocrystals (PNCs) with high water stability. The as-fabricated Try-CsPbCl3 PNCs show λEm/Ex at 433/370 nm with quantum yield of 17.26%. The fluorescence emission spectral characteristics of Try-CsPbCl3 PNCs demonstrated that water-stable Try-CsPbCl3 PNCs acted as a promising fluorescent probe for the detection of hydroxyl radical (•OH) via turn-off mechanism. The Try-CsPbCl3 PNCs-based turn-off fluorescence approach displayed good selectivity for hydroxyl radical in water, showing a wider linear range (0.01–5 µM) with a remarkable detection limit of 3.10 nM for hydroxyl radical. The as-prepared Try-CsPbCl3 PNCs were demonstrated to be a facile probe for sensing •OH in water samples, which signifies that Try-CsPbCl3 PNCs exhibited broad applications for hydroxyl radical sensing and cell imaging.
Risk factors for sporadic infection with non-typhoidal Salmonella among children under five years of age in urban area of Kunming City: a matched case-control study
Authors: Jian Xiaoli , Zhao Jinglin , Wang Wenting , Han Dingrui , He Weizhi , Hang Yaofang , Jiang Li 
Published: December 2024

Abstract

Background
With the urbanization process in China, improving clean water and proper sanitation has reduced fecal-oral transmitted infectious diseases. However, non-typhoidal Salmonella (NTS) infection is relatively prevalent among children. The study aims to explore risk factors associated with NTS infection in young children in urban city areas.
Methods
An age- and sex-matched, case-control study was conducted from May 2022 through April 2023. One hundred one cases and 202 controls who resided in the urban area of Kunming City were interviewed using a standardized questionnaire on exposures three days before illness. The association of each exposure with infection status was determined using conditional logistic regression.
Results
The proportion of diagnoses for NTS infections was the highest in the rainy season (May to October) each year. S. Typhimurium was the most common serotype (64.5%), followed by Enteritidis (11.8%). Permanently storing raw eggs in a refrigerator, no separate cutting board for raw and cooked food, and more than one child living together in the same family were found to be associated with 4.73, 10.38, and 2.69 to 10.16 times increased risk of NTS infections in family children, respectively.
Conclusions
These risk factors are closely related to hygiene habits. Thus, family members should practice good hand hygiene and use correct food storage and handling methods in the domestic setting.
An analysis of factors influencing dropout in methadone maintenance treatment program in Dehong prefecture of China based on cox regression and decision tree modelling
Authors: Zhou Qunbo , Tang Renhai , Yang Yuecheng , Ye Runhua , Gao Jie , Li Lin , Xiang Lifen , Duan Song , Shan Duo 
Published: December 2024

Abstract

Background
The high dropout rate among Methadone Maintenance Treatment (MMT) patients poses a significant challenge to drug dependence treatment programs, especially in regions with prevalent drug use and HIV transmission risks. This study aimed to analyze factors of dropout in MMT clinics over an 18-year period in Dehong Prefecture, Yunnan Province, China.
Methods
A retrospective cohort study was conducted using data from China’s HIV/AIDS Comprehensive Response Information Management System (CRIMS). Participants included individuals who enrolled in MMT between June 2005 and December 2023 and completed baseline surveys. Cox proportional hazards regression and decision tree models were used to identify factors influencing treatment dropout.
Results
The study included 9,435 MMT participants, with a male-to-female ratio of 26:1 (9,086 males and 349 females). The median duration of treatment was 12.2 months (ranging from 2.7 to 43.9 months), with a minimum of 1 day and a maximum of 217 months. The results showed that the dropout rate among MMT patients in Dehong Prefecture, Yunnan Province, from 2005 to 2023 was 89.6% (8,458/9,435). Cox regression analysis indicated that factors significantly associated with higher dropout risk included being a farmer (AHR = 1.52) and a positive urine test (AHR = 2.47), while lower dropout risks were associated with enrollment age over 35 years, being married, a higher education level, relatively good family relationships, and a daily methadone dose > 60 ml. In the decision tree model, the treatment duration was the root node, followed by recent urine test results, family relationships, education level, and methadone dosage.
Conclusion
Between 2005 and 2023, the dropout rate among MMT patients in Dehong Prefecture, Yunnan Province, was relatively high. Traditional risk factors (including age, education level, being marital stutas, and occupation) and potentially modifiable risk factors (including the most recent urine test, relationship with family, and average daily dose) have a significant impact on the increased risk of dropout in MMT. Targeted interventions, such as increasing methadone dosage, enhancing support for patients with positive urine tests, and involving family members in treatment, could improve MMT retention. The use of decision tree models allows for personalized strategies, facilitating better management of dropout risks in high-risk MMT populations.
Impact of Differentiated Service Delivery Models on Quality of Life among People living with HIV in Uganda – A Quasi-Experimental Study
Authors: Nasasira Benson , Banturaki Grace , Kalema Nelson , Musaazi Joseph , Nanvuma Aidah , Okoboi Stephen , Kiarie Nancy , Moitui Joash Ntenga , Kadengye Damazo , Izudi Jonathan , Castelnuovo Barbara 
Published: December 2024

Abstract

Background Differentiated service delivery (DSD) models in resource-limited settings have reduced strain on health services and improved client experience, retention and viral suppression, but little is known about the impact of HIV DSD models on quality of life (QoL), which is essential for optimizing person-centered care. This study assessed the impact of DSD models on QoL, loss to follow-up (LTFU), and mortality among persons living with HIV (PLHIV) on ART over time at a large urban HIV clinic in Uganda.Methods We analyzed records of 1,000 PLHIV who had been on ART for 10 years and followed up for eight years, starting in 2014 or 2015 at the Infectious Diseases Institute clinic in Kampala, Uganda. The primary outcome, QoL, was assessed using an adapted Medical Outcomes Study (MOS-HIV) tool. Secondary outcomes included sustained viral suppression (< 200 copies/mL), all-cause mortality, and loss to follow-up or LTFU (missing clinic visits for ≥ 3 months). Outcomes were compared across three DSD models—fast-track drug refill (FTDR), facility-based groups (FBG), and a composite model combining FTDR and FBG against the facility-based individual management (FBIM), the standard of care (SOC). Inverse probability treatment weighting was used to achieve comparability in measured covariates across the DSD models followed by mixed effects modeling. Robustness of results was checked using G-computation analysis.Results Of 1,000 records for PLHIV, 980 were analyzed. 62% were female and 95% virally suppressed at baseline. After eight years of follow-up, participants on DSD models had higher QoL (90.4% vs 89.1%; weighted mean ratio 3.66, 95% CI 2.10–6.37, p-value < 0.001), better sustained viral suppression, lower mortality, and reduced LTFU rates compared to SOC.Conclusion These findings support the broader adoption of DSD models in delivering ART across HIV programs to enhance the QoL and clinical outcomes among PLHIV.
Investigation of the mechanism of Dan Zhi Qing'e Formula for treating menopausal hot flashes using UHPLC-Q-TOF MS and network pharmacology
Authors: Li Xinyu , Dou Yajie , cai minghui , Wei Shuang , Wang Rui , Xu Nanjian , Qu Jingtian , Wang Yuming 
Published: December 2024

Abstract

Purpose
This study aims to investigate the material basis and underlying mechanisms of action of the Dan Zhi Qing'e Formula in the treatment of menopausal hot flashes.
Methods
The composition analysis of the Dan Zhi Qing'e Formula was conducted using UHPLC-Q-TOF MS, facilitated by MassLynx V4.1 software. Subsequently, Cytoscape 3.10.1 was employed to merge the data with information from Swiss, GeneCards, and OMIM databases to identify the active components and primary targets. GO and KEGG analyses were performed to elucidate the potential mechanisms of action. Finally, molecular docking technique was applied to validate the results.
Results
A total of 117 compounds, 98 blood-absorbed components and 89 potential targets were identified. Molecular docking studies indicate that these core components exhibit strong affinity for the identified targets. These targets contribute to the tonic function of the liver and kidneys through hormone response.
Conclusion
The findings provide a scientific foundation for further in-depth research into the therapeutic mechanisms of Dan Zhi Qing'e Formula for menopausal hot flashes.
The 2011 Tohoku earthquake: Fragility of Japanese buildings to ground shaking
Authors: Ioannou Ioanna , Bertelli Silvia , Chandler Richard E. , Ohno Susumu , Shibayama Akihiro , Suppasri Anawat , Rossetto Tiziana 
Published: December 2024

Abstract

The quality of post-disaster data directly impacts the reliability of empirical fragility curves. Many seismic studies rely on estimated, rather than measured, ground motion intensity due to the limited number of recording stations. However, this study utilizes a unique database of over 7,817 buildings surveyed near 37 ground motion stations in the prefectures of Fukushima, Miyagi and Iwate Prefectures following the 2011 Great Japan earthquake. This research examines damage data inland of the tsunami inundation zone, which has received little attention. A flexible Bayesian framework is employed to construct fragility curves, accounting for data overdispersion and uncertainty in the actual level of ground motion intensity experienced by the buildings. Despite large uncertainties, the results reveal that post-2000 buildings demonstrated superior seismic performance, while pre-1981 buildings were the most vulnerable. Contrary to observations from the 1995 Kobe earthquake, heavy steel frame buildings emerged as the most susceptible to damage, whereas wooden buildings performed similarly to reinforced concrete and light steel frame structures. Additionally, a sensitivity analysis indicates that the difference between the recorded ground motion intensity and the level actually experienced by the buildings surveyed in the station’s vicinity has a negligible impact on the fragility curves.
Predictive Value of Insulin Resistance and GFR-Adjusted Uric Acid Levels on Cardiovascular Mortality: The Urrah Study
Authors: Russo Elisa , Viazzi Francesca , Pontremoli Roberto , Angeli Fabio , Barbagallo Carlo Maria , Berardino Bruno , Bombelli Michele , Cappelli Federica , Casiglia Edoardo , Cianci Rosario , Ciccarelli Michele , Cicero Arrigo Francesco Giuseppe , Cirillo Massimo , Cirillo Pietro , D'Elia Lanfranco , Desideri Giovambattista , Ferri Claudio , Galletti Ferruccio , Gesualdo Loreto , Giannattasio Cristina , Grassi Guido , Iaccarino Guido , Imbalzano Egidio , Lippa Luciano , Mallamaci Francesca , Maloberti Alessandro , Masi Stefano , Masulli Maria , Mazza Alberto , Mengozzi Alessandro , Muiesan Maria Lorenza , Nazzaro Pietro , Palatini Paolo , Parati Gianfranco , Quarti-Trevano Fosca , Rattazzi Marcello , Reboldi Gianpaolo , Rivasi Giulia , Salvetti Massimo , Tikhonoff Valerie , Tocci Giuliano , Ungar Andrea , Verdecchia Paolo , Virdis Agostino , Volpe Massimo , Borghi Claudio 
Published: December 2024

Abstract

Background
Insulin resistance (IR) and serum uric acid (SUA) are closely interconnected: SUA contributes to adversely affects the insulin signaling pathway and contributing to IR, while IR is a known predictor for the development of hyperuricemia. The triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio has been proposed as an easily obtainable marker for IR. This research aimed to investigate the interaction between IR and glomerular filtration rate (GFR)-adjusted uricemia (SUA/GFR ratio) in determining CV risk in a large population cohort study.
Methods
data from 18,694 subjects were analyzed from Uric acid Right foR heArt Healt (URRAH) database. The study evaluated the association between TG/HDL-C ratio and SUA/GFR ratio, as well as their impact on the development of outcomes during the follow-up study period. The primary endpoint was CV mortality.
Results
After a mean follow-up of 124 ± 64 months, 2,665 (14.2%) CV deaths occurred. The incidence of fatal and non-fatal CV events increased in parallel with the increase of TG/HDL-C quintiles. TG/HDL-C ratio showed a positive association with increasing of SUA/GFR ratio, even in non-diabetic patients. Multivariate analysis showed that the TG/HDL-C ratio increases the mortality risk even after adjustment for potential confounding factors. Finally, IR and GFR-adjusted hyperuricemia showed an additive effect on CV mortality.
Conclusions
both IR and SUA/GFR ratio independently predict CV mortality, regardless of age, gender, BMI, diabetes, hypertension and statin use. The joint effect of the TG/HDL-C ratio and the elevated SUA/GFR ratio was greater than the presence of each single risk factors on CV mortality. This highlights the importance of monitoring these markers to better assess cardiovascular risk.
Late Mid-Pleistocene hominin fire control inferred from sooty speleothem analysis
Authors: Vandevelde Ségolène , Pons-Branchu Edwige , Deldicque Damien , Niane Abdou , Mathias Cyrielle , Savard Dany , Perrette Yves , Desachy Bruno , Slimak Ludovic , Bouchard Kevin 
Published: December 2024

Abstract

The origin of fire control is considered a major turning point in human evolution and remains a highly debated albeit central subject in archaeology. Studying paleo-fires is challenging because of taphonomic phenomena that alter combustion structures and hinder the identification of the oldest hearths. Moreover, hearths do not record all fire events and do not provide a chronological record of fire. In contrast, speleothems, carbonated cave deposits, can preserve evidence of ancient fires, including soot traces, and these features can be dated directly using radiometric methods. Orgnac 3, an important archaeological sequence in western Europe, provides a case study on the origins of habitual fire use in this region during the transition between the Lower and Middle Paleolithic. This paper presents the first documented record of over 20 fire events at this ancient site. The habitual use of fire by Mid-Pleistocene hominins at the site is well documented within sooty speleothems, as opposed to relying on scattered and rare traces. The soot deposit sequence at Orgnac 3 is the strongest and best-documented evidence of repeated fire use at the site to date. The robust fire-use chronology is established using stratigraphic U-Th dating of the speleothem. The soot record at Orgnac 3, testifying to fire events during both dry and wet periods, supports the hypothesis that around 270,000 years ago in the Rhone Valley, Mid-Pleistocene hominins could control fire or at least maintain fire throughout the year.
Comparative Analysis of Iridocorneal Angle in Cats and Dogs Using Ultrasound Biomicroscopy: Implications for Glaucoma Prevalence
Authors: Kim Donghee , Jung Ji Seung , Hwang Jiyi , Park Jiwoo , Kwon Myeongjee , Yong Jungyeon , Yoon Haerin , Park Kyung-Mee M. 
Published: December 2024

Abstract

Background
This study aims to investigate the anatomical differences in the anterior segment of the eyes between dogs and cats using ultrasound biomicroscopy (UBM) to understand the higher prevalence of primary angle-closure glaucoma (PACG) in dogs compared to cats.Retrospective analysis was performed on clinical data from 16 eyes of 16 dogs and 14 eyes of 14 cats with normal eye conditions. UBM was utilized to measure nine specific parameters, including Schwalbe's Line Distance (SLD), Iridocorneal Angle (ICA), Angle-Opening Distance (AOD), and three ciliary cleft parameters: width (CCW), length (CCL), and area (CCA). To account for differences in body size, ciliary cleft parameters were adjusted accordingly.
Results
Significant anatomical differences in the anterior segment were found between the two species. Dogs had smaller values for SLD, ICA, AOD, and ciliary cleft parameters (CCW, CCL, CCA) compared to cats. Even after body-size adjustment, the rectified ciliary cleft parameters remained smaller in dogs.
Conclusion
The anatomical differences, particularly the smaller ciliary cleft and narrower drainage angles in dogs, may contribute to the higher prevalence of PACG in this species. Conversely, the larger ciliary cleft in cats may explain the lower occurrence of primary glaucoma in cats.
The Role of Occupational &amp; Industry Education Attainment in Partner Selection: Evidence of Workplace Influence on Spouse's Education Level
Authors: Lee Jun Yeong 
Published: December 2024

Abstract

This study examines the role of occupational and industry education attainment in partner selection, focusing on the influence of workplace environments on spousal education levels. Using data from the American Community Survey(ACS), the research analyzes the average education level of opposite-sex individuals in the same occupation and industry (Occ*Ind Edu) as a predictor of spousal education. Results indicate a significant positive association between occupational education and spousal education for both men and women, with a stronger effect observed for women. This suggests that men and women may use different criteria when selecting a partner, potentially driven by transaction cost reduction and returns on education in the marriage market. In particular, the effect is stronger for couples in the same occupation or industry than for those who are not, which indirectly explains the phenomenon of people meeting and marrying in the same occupation/industry. By treating marriage as a contract and exploring education-based partner selection mechanisms, the findings provide insights into how workplace dynamics and education contribute to spousal selection, with implications for understanding socioeconomic assortative mating.
JEL code: J12, J16, I20
A spinodal decomposition model for the large-scale structure of the universe
Authors: Yadav Nitish 
Published: December 2024

Abstract

The tremendous efforts placed in understanding the structure and galaxy formation in the universe have led to major improvements in our models for the universe. Particular the computational simulations that solve its non-linear growth have painted a clearer picture of the processes behind the enormous scale and shape of the structures observed experimentally. Inspired by porous structure of polymer membranes prepared using phase-inversion, we have taken a fresh-approach to understand how the universe got its present structure. We present the results of a finite-element method based simulation to predict large-scale structure formation in the universe. The novel method applies the Cahn-Hilliard model of spinodal decomposition of a binary mixture to predict the dynamics of matter and dark-energy distribution in the universe. The results closely match the various surveys of matter distribution in the universe and can prove to be an important step towards decreasing the computational resources required for future simulations.
Fiscal Policy and Unemployment in Ethiopia: Evidence from ARDL Model
Authors: Irge Takele Wogari 
Published: December 2024

Abstract

One of the main objectives of macroeconomic and fiscal policy in Ethiopia, as in many other developed and developing nations, is to reduce unemployment. This study examines the impact of fiscal policy on unemployment in Ethiopia from 1990 to 2022. The analysis employed the ARDL Model and cointegration test. The variables analyzed include real gross domestic product (RGDP), government spending, tax income, trade openness, population growth, and the unemployment rate. A stationarity test was conducted, revealing that all variables except population growth were stationary at their first difference. The cointegration test indicated a long-term relationship among the examined variables. Additionally, the ECM results showed that government spending negatively affects unemployment, while tax income has a positive impact. The Granger causality results demonstrated a one-way relationship, with causality flowing from government spending to unemployment. This method provides evidence of a long-term relationship between the unemployment rate and factors such as government spending and tax income. The study suggests that the government should restructure its spending patterns by allocating more funds to productive expenditures and enhance its revenue generation by diversifying Ethiopia's revenue streams.
A Systematic Review on the Effects of Logotherapy and Meaning-Centered Therapy on Psychological and Existential Symptoms in Women with Breast and Gynecological Cancer
Authors: Aiello-Puchol Andrea , García-Alandete Joaquín 
Published: December 2024

Abstract

Purpose Women diagnosed with breast cancer (BC) and gynecological cancer (GC) face psychological challenges common to all cancers, such as anxiety and depression, along with specific issues related to body image and sexuality. Logotherapy and meaning-centered therapy (MCT) have shown positive effects on the psychological well-being of cancer patients.
Methods A systematic review of studies from 2014-2024 that explored the impact of logotherapy and MCT on women diagnosed with BC and GC was conducted following PRISMA guidelines.
Results Findings suggest that logotherapy decreases depressive symptoms, anxiety, and post-traumatic stress, whereas improves meaning in life, quality of life, physical symptom perception, and post-traumatic growth in women with BC and GC.
Conclusion Implementing logotherapy in cancer care units through a multidisciplinary approach could be valuable, considering biopsychosocial factors, and incorporating aspects of self-image and sexuality in treatment would also be beneficial.
Nanoprinting with Crystal Engineering for Perovskite Lasers
Authors: Hu Shiqi , Kim Ji Tae 
Published: December 2024

Abstract

Metal halide perovskites are promising laser light sources due to their exceptional optical gain and solution-processability. Structuring the cavity that determines lasing mode and performance, however, is mostly limited to chemical synthesis or in-plane multi-step lithographic processes, which lead to high shaping rigidity or poor lasing performance. Here, we introduce a direct electrohydrodynamic three-dimensional printing that produces freestanding, high-performance inorganic perovskite sub-micro lasers with tailored dimensions and locations, assisted by crystal engineering. The printed vertical nanowires exhibit excellent crystallinity after vapor-phase solvent engineering. Therefore, they show a high-performance two-photon pumped Fabry–Pérot mode vertical lasing with a threshold of 2.98 µJ/cm2, and our on-demand printing method provides the simplest route to tune the lasing characteristics such as lasing threshold and mode spacing, by adjusting the printed nanowire length. We demonstrated that the length-dependent lasing in the printed arrays can configure multi-level anticounterfeiting labels. We expect this additive manufacturing approach combined with crystal engineering to improve the design flexibility and performance of micro photonic circuitries.