bluuebunny/crossref_metadata_2025_split huggingface dataset:
Constructing the social network prediction model based on data mining and link prediction analysis
Authors: Gao Yuxian 
Published: January 2020

Purpose
The purpose of this paper is to apply link prediction to community mining and to clarify the role of link prediction in improving the performance of social network analysis.

Design/methodology/approach
In this study, the 2009 version of Enron e-mail data set provided by Carnegie Mellon University was selected as the research object first, and bibliometric analysis method and citation analysis method were adopted to compare the differences between various studies. Second, based on the impact of various interpersonal relationships, the link model was adopted to analyze the relationship among people. Finally, the factorization of the matrix was further adopted to obtain the characteristics of the research object, so as to predict the unknown relationship.

Findings
The experimental results show that the prediction results obtained by considering multiple relationships are more accurate than those obtained by considering only one relationship.

Research limitations/implications
Due to the limited number of objects in the data set, the link prediction method has not been tested on the large-scale data set, and the validity and correctness of the method need to be further verified with larger data. In addition, the research on algorithm complexity and algorithm optimization, including the storage of sparse matrix, also need to be further studied. At the same time, in the case of extremely sparse data, the accuracy of the link prediction method will decline a lot, and further research and discussion should be carried out on the sparse data.

Practical implications
The focus of this research is on link prediction in social network analysis. The traditional prediction model is based on a certain relationship between the objects to predict and analyze, but in real life, the relationship between people is diverse, and different relationships are interactive. Therefore, in this study, the graph model is used to express different kinds of relations, and the influence between different kinds of relations is considered in the actual prediction process. Finally, experiments on real data sets prove the effectiveness and accuracy of this method. In addition, link prediction, as an important part of social network analysis, is also of great significance for other applications of social network analysis. This study attempts to prove that link prediction is helpful to the improvement of performance analysis of social network by applying link prediction to community mining.

Originality/value
This study adopts a variety of methods, such as link prediction, data mining, literature analysis and citation analysis. The research direction is relatively new, and the experimental results obtained have a certain degree of credibility, which is of certain reference value for the following related research.
“Less is more”
Authors: Zhang Ziqi , Bors Georgica 
Published: December 2019

Purpose
This work studies automated user classification on Twitter in the public health domain, a task that is essential to many public health-related research works on social media but has not been addressed. The purpose of this paper is to obtain empirical knowledge on how to optimise the classifier performance on this task.

Design/methodology/approach
A sample of 3,100 Twitter users who tweeted about different health conditions were manually coded into six most common stakeholders. The authors propose new, simple features extracted from the short Twitter profiles of these users, and compare a large set of classification models (including state-of-the-art) that use more complex features and with different algorithms on this data set.

Findings
The authors show that user classification in the public health domain is a very challenging task, as the best result the authors can obtain on this data set is only 59 per cent in terms of F1 score. Compared to state-of-the-art, the methods can obtain significantly better (10 percentage points in F1 on a “best-against-best” basis) results when using only a small set of 40 features extracted from the short Twitter user profile texts.

Originality/value
The work is the first to study the different types of users that engage in health-related communication on social media, applicable to a broad range of health conditions rather than specific ones studied in the previous work. The methods are implemented as open source tools, and together with data, are the first of this kind. The authors believe these will encourage future research to further improve this important task.
Genetic variants associated with T cell–mediated cutaneous adverse drug reactions: A PRISMA‐compliant systematic review—An EAACI position paper
Authors: Oussalah Abderrahim , Yip Vincent , Mayorga Cristobalina , Blanca Miguel , Barbaud Annick , Nakonechna Alla , Cernadas Josefina , Gotua Maia , Brockow Knut , Caubet Jean‐Christoph , Bircher Andreas , Atanaskovic‐Markovic Marina , Demoly Pascal , Kase‐Tanno Luciana , Terreehorst Ingrid , Laguna José Julio , Romano Antonino , Guéant Jean‐Louis , Pirmohamed Munir ,   the Task Force “Genetic predictors of drug hypersensitivity” of the European Network on Drug Allergy (ENDA), European Academy of Allergy and Clinical Immunology (EAACI)
Published: January 2020

AbstractDrug hypersensitivity reactions (DHRs) are associated with high global morbidity and mortality. Cutaneous T cell–mediated reactions classically occur more than 6 hours after drug administration and include life‐threatening conditions such as toxic epidermal necrolysis, Stevens‐Johnson syndrome, and hypersensitivity syndrome. Over the last 20 years, significant advances have been made in our understanding of the pathogenesis of DHRs with the identification of human leukocyte antigens as predisposing factors. This has led to the development of pharmacogenetic screening tests, such as HLA‐B*57:01 in abacavir therapy, which has successfully reduced the incidence of abacavir hypersensitivity reactions. We have completed a PRISMA‐compliant systematic review to identify genetic associations that have been reported in DHRs. In total, 105 studies (5554 cases and 123 548 controls) have been included in the review reporting genetic associations with carbamazepine (n = 31), other aromatic antiepileptic drugs (n = 24), abacavir (n = 11), nevirapine (n = 14), trimethoprim‐sulfamethoxazole (n = 11), dapsone (n = 4), allopurinol (n = 10), and other drugs (n = 5). The most commonly reported genetic variants associated with DHRs are located in human leukocyte antigen genes and genes involved in drug metabolism pathways. Increasing our understanding of genetic variants that contribute to DHRs will allow us to improve diagnosis, develop new treatments, and predict and prevent DHRs in the future.
When smiles (and frowns) speak words: Does power impact the correspondence between self‐reported affect and facial expressions?
Authors: Leach Stefan , Weick Mario 
Published: January 2020

Self‐reported experiences are often poor indicators of outward expressions. Here we examine social power as a variable that may impact the relationship between self‐reported affect and facial expressions. Earlier studies addressing this issue were limited by focusing on a single facial expression (smiling) and by using different, less sensitive methods that yielded mostly null results. Sampling, for the first time, self‐reported affect repeatedly in response to different negative, neutral and positive stimuli, and measuring concurrent facial muscle activation via electromyography, we found that high power (vs. baseline) increased the correspondence between self‐reported positive affect and smiling. There was also an indication that high power (vs. baseline) bolstered the association between self‐reported negative affect and frowning but the effect did not pass more stringent criteria for significance (p ≤ .005) and was therefore deemed inconclusive. The prediction that low power (vs. baseline) decreases the correspondence between self‐reported affect and smiling and frowning facial expressions was not supported. Taken together, it would appear that (high) power can impact the relationship between self‐reported affect and facial expressions, but it remains to be seen whether this effect extends beyond smiling facial expressions.
Non‐syndromic X linked intellectual disability: Current knowledge in light of the recent advances in molecular and functional studies
Authors: Tejada María Isabel , Ibarluzea Nekane 
Published: January 2020

AbstractSince the discovery of the FMR1 gene and the clinical and molecular characterization of Fragile X Syndrome in 1991, more than 141 genes have been identified in the X‐chromosome in these 28 years thanks to applying continuously evolving molecular techniques to X‐linked intellectual disability (XLID) families. In the past decade, array comparative genomic hybridization and next generation sequencing technologies have accelerated gene discovery exponentially. Classically, XLID has been subdivided in syndromic intellectual disability (S‐XLID)—where intellectual disability (ID) is always associated with other recognizable physical and/or neurological features—and non‐specific or non‐syndromic intellectual disability (NS‐XLID) where the only common feature is ID. Nevertheless, new advances on the study of these entities have showed that this classification is not always clear‐cut because distinct variants in several of these XLID genes can result in S‐XLID as well as in NS‐XLID. This review focuses on the current knowledge on the XLID genes involved in non‐syndromic forms, with the emphasis on their pathogenic mechanism, thus allowing the possibility to elucidate why some of them can give both syndromic and non‐syndromic phenotypes.
Objectives versus realities: Spatial, temporal, financial and social deficiencies in Australia’s public revegetation investment model
Authors: Collard Stuart J. , O’Connor Patrick J. , Prowse Thomas A. A. , Gregg Daniel , Bond Anthelia J. 
Published: December 2019

SummaryPast and continuing fragmentation and modification of ecosystems, as well as other threatening processes, cause ongoing biodiversity losses and species extinctions in Australia. At the same time as biodiversity declines, government funding for conservation and restoration is diminishing, leading to reduced action and greater reliance on private investment and community groups. In order to maintain and restore biodiverse ecosystems and the essential services they provide, both conservation of existing vegetation and habitat reconstruction are required. In this paper, we summarise the available data on planting area and cost from the Australian Government’s 20 Million Trees programme (2014–2020), the largest recent national‐scale revegetation incentives programme in Australia. We find that the current spatial scale of effort and investment in habitat reconstruction is insufficient to match the scale required to meet national conservation objectives. Furthermore, the funding rate ($/ha) and contracting arrangements are inadequate for the establishment of high‐quality self‐sustaining vegetation needed for the recovery of Australia’s threatened species and ecological communities. We estimate that the minimum amount of funding required for habitat reconstruction is at least five times higher than is provided for current national flagship programmes such as 20 Million Trees. We provide recommendations, designed to assist future habitat reconstruction programmes achieve their long‐term biodiversity objectives.
Glutamate dehydrogenase deficiency disrupts glutamate homeostasis in hippocampus and prefrontal cortex and impairs recognition memory
Authors: Lander Sharon Sima , Chornyy Sergiy , Safory Hazem , Gross Amit , Wolosker Herman , Gaisler‐Salomon Inna 
Published: January 2020

AbstractGlutamate Dehydrogenase 1 (GDH), encoded by the Glud1 gene in rodents, is a mitochondrial enzyme critical for maintaining glutamate homeostasis at the tripartite synapse. Our previous studies indicate that the hippocampus may be particularly vulnerable to GDH deficiency in central nervous system (CNS). Here, we first asked whether mice with a homozygous deletion of Glud1 in CNS (CNS‐Glud1 −/− mice) express different levels of glutamate in hippocampus, and found elevated glutamate as well as glutamine in dorsal and ventral hippocampus, and increased glutamine in medial prefrontal cortex (mPFC). l‐serine and d‐serine, which contribute to glutamate homeostasis and NMDA receptor function, are increased in ventral but not dorsal hippocampus, and in mPFC. Protein expression levels of the GABA synthesis enzyme glutamate decarboxylase (GAD) GAD67 were decreased in the ventral hippocampus as well. Behavioral analysis revealed deficits in visual, spatial and social novelty recognition abilities, which require intact hippocampal‐prefrontal cortex circuitry. Finally, hippocampus‐dependent contextual fear retrieval was deficient in CNS‐Glud1 −/− mice, and c‐Fos expression (indicative of neuronal activation) in the CA1 pyramidal layer was reduced immediately following this task. These data point to hippocampal subregion‐dependent disruption in glutamate homeostasis and excitatory/inhibitory balance, and to behavioral deficits that support a decline in hippocampal‐prefrontal cortex connectivity. Together with our previous data, these findings also point to different patterns of basal and activity‐induced hippocampal abnormalities in these mice. In sum, GDH contributes to healthy hippocampal and PFC function; disturbed GDH function is relevant to several psychiatric and neurological disorders.
Unifying NAPL Drawdown and Transmissivity Testing in Unconfined, Confined, Perched, and Fractured Settings using the Z‐Factor and MH Principles
Authors: Kirkman Andrew J. , Koons Brad 
Published: January 2020

AbstractLight nonaqueous phase liquid (LNAPL) flow in in fractured rock is governed by the same physics as porous media, but LNAPL discharge to a well from fractured rock is subject to the unique geometry of the fractures within the rock and the degree of interconnectivity between the factures. Previous conceptualization and definition of drawdown of nonaqueous phase liquids (NAPL) has employed a single drawdown value to represent the entire vertical interval of mobile NAPL. Application of the single drawdown model may result in erroneous calculation of NAPL transmissivity in fractured rock settings. This work illustrates how drawdown in multiphase systems can be variable over the vertical interval of mobile NAPL. In settings with discrete fracture networks, it is clear that consistently applying a single drawdown value will not accurately represent the pressure gradients. This work presents the multiphase head (MH) model, which is proposed as a comprehensive methodology for evaluating NAPL drawdown in fractured rock, and unconsolidated porous media. The MH model utilizes fluid statics and physical principles to accurately represent pressure differences in the formation and convert those into NAPL drawdown for discrete elevations. This first principles approach to describing how drawdown varies with NAPL‐production zone elevations and fluid levels, resulting in a more accurate representation of discharge vs. fluid elevation behavior. Application of the MH model to various scenarios has identified that dissimilar scenarios can represent similar behavior during recovery from a NAPL removal event or baildown test. The resulting understanding improves the selection of representative portions of baildown test data to use in NAPL transmissivity analysis. Proper conceptualization of drawdown in bedrock identifies an alternate analysis method, the Z‐factor, to estimate NAPL transmissivity. The resulting drawdown calculations and transmissivity analysis method result in a comprehensive approach to calculating NAPL transmissivity in both bedrock and unconsolidated porous media.
Preservation of Epstein–Barr virus status and mismatch repair protein status along the metastatic course of gastric cancer
Authors: Dislich Bastian , Blaser Nicola , Berger Martin D , Gloor Beat , Langer Rupert 
Published: January 2020

AimsEpstein–Barr virus (EBV) in‐situ hybridisation and mismatch repair (MMR) protein immunohistochemistry identifies two subgroups of gastric cancer (GC) with high immunogenicity and likelihood for response to immune check‐point inhibition. As tumour biology may change during the metastatic course, which can negatively influence the success of therapeutic decisions made on primary tissue, we investigated the consistency of GC EBV and MMR status within primary tumours and metastases.Methods and resultsWe investigated a cohort of 415 primary resected GC, including 111 cases with corresponding distant metastases and 297 cases with lymph node metastases. Tumours were analysed by EBV in‐situ hybridisation and MLH1, PMS2, MSH2 and MSH6 immunohistochemistry using tissue microarray technique. Primary tumours were grouped as EBV‐positive MMR‐proficient, EBV‐negative MMR‐deficient and EBV‐negative MMR‐proficient. Eleven of 415 (2.7%) of primary tumours were EBV‐positive MMR‐proficient, whereas 49 of 415 (11.8%) of tumours were EBV‐negative MMR‐deficient. EBV and MMR protein status showed full concordance with that of the primary tumours. MMR‐deficient tumours were of lower pT‐category (P < 0.001), had fewer lymph node metastases [24 of 49 (49%) versus 273 of 361 (75.6%) cases; P < 0.001] and a lower rate of distant metastases [six of 49 (12.2%) versus 105 of 366 (28.7%) cases; P = 0.015].ConclusionWe demonstrate a strong correlation of EBV and MMR status between primary tumours, lymph node and distant metastases in a large series of primary resected GC. The cases showed the expected frequency of EBV‐positive MMR‐deficient and EBV‐negative MMR‐proficient tumours. We conclude that tissue testing for molecular subtyping for therapeutic decision‐making can be reliably performed on primary tumours and metastases in GC.
Is negative the new positive? Secondary transfer effect of exposure to LGBT portrayals in TV entertainment programs
Authors: Lissitsa Sabina , Kushnirovich Nonna 
Published: December 2019

AbstractThis study investigates the primary effect of positive, neutral, and negative exposure to Lesbian, Gay, Bisexual, and Transgender (LGBT) TV portrayals in entertainment programs on attitudes toward the LGBT community and the Secondary Transfer Effect (STE) of such exposure on attitudes toward people with Asperger's Disorder (the secondary out‐group), controlling for face‐to‐face and online contacts with both out‐groups. Research was conducted using a mixed methods approach. Quantitative Study 1 used an online survey of 716 Israeli Jews, to investigate primary and secondary effects of TV exposure to LGBT portrayals. The positive primary effect of TV exposure was shown—regardless of LGBT portrayals perceived as positive, neutral, or negative. STE of TV exposure to neutral and negative LGBT portrayals is likely to diminish social distance to people with Asperger's Disorder, while no STE was found with positive LGBT portrayals. Full mediation effect of attitudes toward the LGBT community was found. Qualitative Study 2, based on 52 in‐depth interviews, was conducted in order to reveal the hidden mechanisms of these effects, examining the parasocial experience and its interpretations by the viewers. According to qualitative findings, the positive primary and secondary effects of negative exposure may be explained by varied interpretations of gay portrayals on TV by different people depending on social background and life experience, opposite reaction on stereotypical gay portrayals on TV, and asymmetrical negative‐positive heuristic. Given the important role of TV in fostering more positive intergroup relations, this research revealed sources of prejudice reduction and increase in tolerance toward “others” for society at large.
Management of aging skin: A questionnaire‐based study among Indian dermatologists
Authors: Agarwal Madhuri , Poojary Priya , Panda Madhumita , Gogtay Jaideep 
Published: December 2019

AbstractIntroductionWith increased life expectancy, the desire to look younger has increased. Hence, many patients approach dermatologists for antiaging treatment. However, data regarding management of skin aging in India are scarce.AimsTo understand management patterns for skin aging among dermatologists in India.MethodsOverall, 147 Indian dermatologists were administered a questionnaire‐based survey about patient characteristics, signs of skin aging, treatment options, and cost.ResultsAmong all the patients coming for dermatologists' consultation, 10%‐40% were for antiaging treatment. About 70% dermatologists opined that majority of patients aged 30‐40 years consulted for antiaging treatment, and the male to female ratio was 3:7. Approximately 46% of dermatologists felt that antiaging treatment should be initiated by the age of 30. Common signs of aging were wrinkles, pigmentation, dull skin or complexion, and dry skin. Based on patient's age and sex, dermatologists prescribed a combination of 2‐4 products, which included antioxidants, retinoids, growth factors, and moisturizers. Improvement was assessed by photographic and clinical evaluation, and by patients' satisfaction (55%). Effect of the antiaging products was evident within 4‐6 months. Earliest improvement was noted in dry skin and dull complexion. Average extent of improvement noted by 6 months was approximately 20%‐30%. The average monthly expenditure on antiaging treatments was 2000‐4000 INR.ConclusionBoth men and women seek clinical treatment for skin aging in India. Dermatologists prescribe a combination of 2‐4 products, including antioxidants, retinoids, growth factors, and moisturizers. Available antiaging therapies show an average improvement of up to 30% by 6 months.
End of life in acute hospital setting—A systematic review of families' experience of spiritual care
Authors: Hennessy Nora , Neenan Kathleen , Brady Vivienne , Sullivan Melissa , Eustace-Cooke Jessica , Timmins Fiona 
Published: December 2019

AbstractAims and objectivesTo systematically review qualitative studies exploring families' experiences of spiritual care at the end of life in acute hospital settings.BackgroundAlthough there is a widespread belief that the consideration of spiritual and religious needs is outdated in the context of secularism, from a practical perspective patients and families appear to benefit from spiritual support at the end of life.MethodsSix key databases, CINAHL, MEDLINE, EMBASE, Global Health Library, Web of Science and Applied Social Sciences Index and Abstracts (ASSIA), were searched, and three reviewers independently extracted the data and coded them into themes and subthemes. The Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) was used as a reporting framework.ResultsFive main themes emerged: anticipating needs; honouring the family by honouring the patient; personal connection; lack of sensitivity; and making space for religious and spiritual practices.ConclusionsFamilies experiencing end‐of‐life care in acute hospital settings may benefit from spiritual care. While this can also be considered as fundamental care, understanding this through the lenses of spiritual care allows for incorporation of religious and spiritual practices that many seek at this time, irrespective of their faith perspectives.Relevance to clinical practiceAlthough hospice care is well established internationally, many families experience end‐of‐life care in acute hospital settings. Nurses usually get to know families well during this time; however, the demands of the clinical environment place restrictions on family care and perceptions of lack of communication, limited support and/or limited sensitivity can compound families' suffering. Consideration of families' spiritual needs can help to support families during this time. Nurses are ideally placed for this and can anticipate and plan for patient and family needs in this regard, or refer to a specialist, such as the Healthcare Chaplain.