bluuebunny/crossref_metadata_2025_split huggingface dataset:
CT-based radiomic prognostic vector (RPV) predicts survival and stromal histology in high-grade serous ovarian cancer: an external validation study
Authors: Wengert Georg J. , Lu Haonan , Aboagye Eric O. , Langs Georg , Poetsch Nina , Schwartz Ernst , Bagó-Horváth Zsuzsanna , Fotopoulou Christina , Polterauer Stephan , Helbich Thomas H. , Rockall Andrea G. 
Published: December 2024

Abstract
Objectives
In women with high-grade serous ovarian cancer (HGSOC), a CT-based radiomic prognostic vector (RPV) predicted stromal phenotype and survival after primary surgery. The study's purpose was to fully externally validate RPV and its biological correlate.

Materials and methods
In this retrospective study, ovarian masses on CT scans of HGSOC patients, who underwent primary cytoreductive surgery in an ESGO-certified Center between 2002 and 2017, were segmented for external RPV score calculation and then correlated with overall survival (OS) and progression-free survival (PFS). A subset of tissue samples subjected to fibronectin immunohistochemistry were evaluated by a gynaeco-pathologist for stromal content. Kaplan–Meier log-rank test and a Cox proportional hazards model were used for outcome analysis.

Results
Among 340 women with HGSOC, 244 ovarian lesions were available for segmentation in 198 women (mean age 59.8 years, range 34–92). Median OS was 48.69 months (IQR: 27.0–102.5) and PFS was 19.3 months (IQR: 13–32.2). Using multivariate Cox analysis, poor OS was associated with RPV-high (HR 3.17; 95% CI: 1.32–7.60; p = 0.0099), post-operative residual disease (HR 2.04; 95% CI: 1.30–3.20; p = 0.0020), and FIGO stage III/IV (HR 1.79; 95% CI: 1.11–2.86; p = 0.016). Age did not influence OS. RPV-high tissue had higher stromal content based on fibronectin expression (mean 48.9%, SD 10.5%) compared to RPV-low cases (mean 14.9%, SD 10.5%, p < 0.0001). RPV score was not significantly associated with PFS.

Conclusion
Patients with HGSOC and RPV-high ovarian mass on pre-operative CT had significantly worse OS following primary surgery and a higher stromal content compared to RPV-low masses, externally validating the RPV and its biological interpretation.

Key Points
QuestionCan the performance of a previously described RPV in women with HGSOC be replicated when licenced to an external institution?
FindingsExternal validation of RPV among 244 ovarian lesions demonstrated that, on multivariate analysis, OS was associated with RPV, stage, and postoperative residual disease, replicating previous findings.
Clinical relevanceExternal validation of a radiomic tool is an essential step in translation to clinical applicability and provides the basis for prospective validation. In clinical practice, this RPV may allow more personalized decision-making for women with ovarian cancer being considered for extensive cytoreductive surgery.
Das ärztliche Strafbarkeitsrisiko beim Weaning von Langzeitbeatmeten
Authors: Tietz Kimberley 
Published: December 2024

ZusammenfassungDurch die Verpflichtung zur regelmäßigen Erhebung des Weaningspotenziales gem. §37c
SGB V ist mit einem Anstieg der Weaningversuche bei Langzeitbeatmeten in der außerklinischen Intensivpflege
zu rechnen. Diese sind dabei regelmäßig einem hohen Mortalitätsrisiko ausgesetzt. Daraus
ergeben sich Fragen zur ärztlichen Strafbarkeit, die den medizinischen Standard und die Aufklärungsanforderungen
beim Weaning zum Gegenstand haben. Auch wenn die hohen Beweisanforderungen das Strafbarkeitsrisiko häufig
begrenzen werden, können insbesondere Fehler bei der Indikationsstellung zu einer Strafbarkeit führen.
Empty nose syndrome: new insights from a CFD approach
Authors: Esteban-Ortega Francisco , Rosique-López Lina , Ochoa-Ríos Jaime A. , Rodríguez-Romero Rafael , Burgos-Olmos Manuel A. 
Published: December 2024

Abstract
Objectives
Empty Nose Syndrome (ENS) is a debilitating condition which usually arises after aggressive turbinate reduction. However, objective tests to help in the diagnosis of this condition are lacking. Accurate diagnosis of ENS patients is critical for effective diagnosis and treatment. The article's objectives are to utilize computational fluid dynamics (CFD) to analyze nasal airflow resistance and symmetry in suspected ENS patients, classify them into distinct groups based on CFD data, and demonstrate the potential of CFD analysis in refining ENS diagnosis and guiding individualized treatment strategies.

Methods
This study involved 48 patients diagnosed of ENS. However, we only considered those patients with documented prior turbinate surgery (eventually plus septal surgery), CT scan with signs of prior surgery, and a history of ENS with symptoms included in the ENS Q6. We employed computational fluid dynamics (CFD) to analyze nasal airflow resistance and symmetry. Patients were classified into three groups based on their CFD data: low resistance and normal symmetry, evident asymmetry, and normal CFD parameters.

Results
Half of patients (24 out of 48) were found in the low resistance and normal symmetry group, indicating ‘typical’ ENS. A smaller group (8) exhibited evident asymmetry, suggesting unilateral ENS or failure of previous surgery. Finally, 16 patients whose CFD parameters are inside the normal range of flow and resistance were classified in the normal breathing group.

Conclusions
Our findings highlight the value of CFD analysis in classifying ENS patients based on airflow characteristics, as CFD analysis seems helpful in refining the diagnosis of ENS. This classification system can potentially aid in tailoring individual treatment strategies and improving patient outcomes. Further research is necessary to validate these results and explore the clinical implications of different ENS subgroups.

Level of evidence
Level 4 [1].
SAGES guidelines for the management of comorbidities relevant to metabolic and bariatric surgery
Authors: Kumar Sunjay S. , Wunker Claire , Collings Amelia , Bansal Varun , Zoumpou Theofano , Chang Julietta , Rodriguez Noe , Sabour Andrew , Hilton Lisa Renee , Ghanem Omar M. , Kushner Bradley S. , Loss Lindsey Jean , Aleassa Essa M. , Haskins Ivy N. , Ayloo Subhashini , Reid Adam , Overby David Wayne , Hallowell Peter , Kindel Tammy Lyn , Slater Bethany J. , Palazzo Francesco 
Published: December 2024

Abstract

Background
Patients who are under consideration for or have undergone metabolic and bariatric surgery frequently have comorbid medical conditions that may make their perioperative care more complex. These recommendations address routine intraoperative cholangiography in patients with bypass-type anatomy, the management of reflux disease after sleeve gastrectomy, and the optimal bariatric procedure for patients with comorbid inflammatory bowel disease.

Methods
A systematic review was conducted including studies published from 1990 to 2022 to address these questions. These results were then presented to a panel of bariatric surgeons who formulated recommendations based on the best available evidence or utilized expert opinion when the evidence base was lacking.

Results
Conditional recommendations were made in favor of routine intraoperative cholangiography in patients with bypass-type anatomy undergoing laparoscopic cholecystectomy, trialing medical management prior to surgical management in patients with reflux after sleeve gastrectomy, and sleeve gastrectomy rather than Roux en Y gastric bypass in patients with inflammatory bowel disease. The strength of these recommendations was limited by the quality of evidence available. Recommendations for future research were made for all questions.

Conclusions
These recommendations should provide guidance regarding management of these comorbidities in patients who are under consideration for or have undergone metabolic and bariatric surgery. These recommendations also identify important areas where the future research should focus to strengthen the evidence base.
Full moon mesencephalon sign: a transient cytotoxic lesion in a hemodialysis patient with newly diagnosed atrial fibrillation and severe stenosis of the right vertebral artery
Authors: Sassi Celeste , Habermann Sylvia , Coria Marcelo Alejandro , Grüger Albert , Kola Vasilis , Schmitt Hans-Michael 
Published: December 2024

AbstractBrain cytotoxic edema is a neuroradiological sign secondary to variegate diseases ranging from migraine to fulminant Listeria rhombencephalitis. The tempestive identification of its underlying cause is vital for an effective treatment as any delay may be fatal. However, the lack of distinctive imaging biomarkers and the paucity of reports pose a significant challenge in its diagnosis and frequently lead to a misdiagnosis particularly with the more common acute ischemic stroke. Importantly, due to its rarity, mesencephalon midline cytotoxic lesion is likely to remain an underdiagnosed clinical phenomenon, especially if follow up MRI is not performed. Here we report a case of a central, midline, symmetric midbrain cytotoxic edema in a haemodialysis patient with diverse chronic progressive severe cardiovascular risk factors and a newly diagnosed atrial fibrillation. We expand the spectrum of neuroradiological hallmarks associated to terminal renal failure and report a full moon-like mesencephalon midline transient restricted diffusion as a reliable imaging biomarker for the prompt and accurate diagnosis of midbrain cytotoxic edema with the enormous potential of rapidly identifying and effectively treating its causative factors and timely reverse the associated symptomatic.
Low-risk individuals with primary biliary cholangitis and significant liver stiffness: prognosis and treatment
Authors: Ding Dawei , Hu Yinan , Jia Gui , Wang Boling , Zheng Linhua , Deng Juan , Sun Ruiqing , Wang Xiufang , Guo Guanya , Cui Lina , Shang Yulong , Han Ying 
Published: December 2024

Abstract
Background
Some patients treated with ursodeoxycholic acid (UDCA) or combined fenofibrate had well-controlled biochemical parameters but high liver stiffness, and the prognosis as well as therapeutic options for these patients may be an area worthy of further exploration.

Aims
To explore the prognosis and treatment of patients with low-risk and high liver stiffness.

Methods
A retrospective study included 424 cases of UDCA monotherapy and 102 cases of combined fenofibrate treatment.

Results
The combination of liver stiffness measurement (LSM) and the GLOBE score improved prognostic prediction for patients with UDCA monotherapy (area under the receiver operating characteristic curve [AUC] of 0.868 (0.811–0.925) for the fitted model and 0.834 (0.767–0.900) for the GLOBE score, p = 0.006). Further analyses revealed that LSM had an additive prognostic effect mainly in low-risk patients defined by GLOBE < 0.5 (AUC, 0.777 [0.724–0.825] vs 0.642 [0.583–0.699], p = 0.001). For patients in the low-risk group, the prognosis was worse when LSM > 11 kPa (7/53 [13%] vs 2/227 [1%], p = 0.001). The prognosis was consistent between patients in the “low-risk and LSM > 11 kPa” group and the medium-risk group defined by 0.5 < GLOBE < 1.8 (7/53 [13%] vs 22/121 [18%], p = 0.418). In low-risk patients treated with combined fenofibrate therapy, the prognosis was worse when LSM > 11 kPa (3/21 [14%] vs 0/47 [0%], p = 0.022). The prognosis was consistent between patients in the “low-risk and LSM > 11 kPa” and the medium-risk groups (3/21 [14%] vs 6/27 [22%], p = 0.353). Antifibrotic drugs failed to reduce the incidence of the primary outcome (5/45 [11%] vs 5/27 [19%], p = 0.598), and delayed the progression of LSM in patients with low-risk and LSM > 11 kPa at 36 months of follow-up (changes in LSM, − 3.31 [− 5.04 to − 1.52] vs − 1.74 [− 2.83 to 1.5], p = 0.046).

Conclusions
Patients with GLOBE-defined low-risk and LSM > 11 kPa had a poor prognosis, and antifibrotic therapy may slow the progression of liver stiffness in these patients.
Changes in volunteers’ attitudes towards mental illness after remote volunteering support
Authors: Pinto da Costa Mariana , Kantaveenam Varshini , Ahmed Najma 
Published: December 2024

Abstract
The social contact hypothesis posits that direct contact between different groups can reduce prejudice under specific conditions, and has been foundational in promoting social cohesion and reducing discrimination. Given that people with mental illness often face stigma and discrimination, it is important to evaluate how community volunteering programmes can impact attitudes towards people with mental illness. This study therefore explores how remote interactions between community volunteers and individuals with mental illness impact the volunteers’ perceptions of mental health. Through a qualitative secondary analysis, we examined data from a 12-week remote volunteering support intervention. Interviews with 17 patients and 17 volunteers were conducted in the United Kingdom, where participants were recruited. The analysis revealed three key themes: volunteers’ preconceptions prior to the intervention, volunteers’ challenges when interacting with patients, and volunteers’ improved attitudes towards patients with mental illness post-intervention. Notably, 35% of volunteers reduced their desire to socially distance from individuals with mental illness, while 53% reported no change, and 12% reported an increase. These remote interactions fostered greater understanding and have potential to reduced stigma surrounding mental illness.
Problematising Sharenting of Supermoms in a Neoliberal Context
Authors: Alkan Deniz Palalar , Gündüz Safak , Ozbilgin Mustafa , Kamasak Rifat 
Published: December 2024

Abstract
The representation of motherhood using digital platforms, which we call sharenting, can shape the socially constructed motherhood identity, i.e., supermoms in modern societies. Despite building a positive identity as mothers, supermoms may unintentionally violate their children’s privacy, instrumentalise, and even monetise the children. We examine sharenting and supermom identities as manifestations of neoliberal repositioning women as mothers and employees with little consideration of their unarticulated struggles. Drawing on a netnographic study of social media practices, we analysed fifteen working supermom accounts with over two hundred thousand followers, where child-related content was shared and posted between 2019 and 2023. We find that sharenting is often employed to construct the identity of supermoms, yet it frequently leads to the exploitation of children for profit-driven purposes, thereby increasing their vulnerability. We contribute to the literature by offering empirical evidence that the supermom identity is a by-product of the neoliberal system, which normalises time-intensive demands on women in the workplace and caregiving roles. Furthermore, we highlight the adverse consequences of sharenting and provide critical insights into the privacy and security risks associated with child-related digital content.
Infant acute myeloid leukemia: insights into the biology and therapy
Authors: Chen Xiaoli , Jin Linlin , Hu Tianyuan , Zhu Xiaofan 
Published: December 2024

AbstractInfant Acute Myeloid Leukemia (IAML), which manifests within the first two years of life, represents a distinct subtype of childhood acute leukemia characterized by unique clinical and biological features. The incidence of IAML is comparable to that of infant acute lymphoblastic leukemia (IALL), and represents approximately 10–25% of childhood AML cases. Despite improvements in overall survival (OS) rates achieved through risk stratification, stratified chemotherapy, and supportive care, the clinical efficacy of conventional treatment remains constrained. Challenges persist in enhancing the initial remission rate and mitigating relapse after remission. In recent years, the in-depth researches and integrated application of hematopoietic stem cell transplantation (HSCT), targeted therapy, and immunotherapy have introduced novel strategies for precise treatment and personalized clinical management of the disease. This review provides a comprehensive summary of the epidemiological, clinical, and biological characteristics of IAML, along with an exploration of the current stage of treatment research progress.
Thermo-hydraulic and exergy characteristics of a triple tube helical coil with inner triangular twisted tube
Authors: Abdelmagied Mahmoud 
Published: December 2024

AbstractThe thermo-hydraulic and exergy characteristics of a new design called a triple tube helical coil with an inner triangular twisted tube, TTHCITTT, were explored experimentally. The structure of the new design involved a modified inner twisted fluid path for the inner tube of a triple tube helical coil with an inner triangular twisted tube. The study involved the impact of various designing parameters such as twisted pitch ratio, coil torsion, coil inclination angle, Dean number, and double tube helical coil with an inner triangular twisted tube, as a particular reference. The experimental runs were carried out at a wide range of inner annulus Reynolds numbers from 3000 to 26,900 corresponding to velocities of 0.05 to 2.05 m s−1. The main remarks show that the triple tube helical coil with an inner triangular twisted tube presents superior thermo-hydraulic and exergetic characteristics compared to the double tube helical coil with an inner triangular twisted tube by 73.68%. While the twisted pitch ratio increased from ∞ (smooth) to 4.69, the Nusselt number was enhanced by 24.7% at the expense of increasing the friction factor by 36.4%. The coil torsion presents a noticeable impact on increasing the Nusselt number by 18.8% while the increase in fh is approximately 12%. The coil inclination angles of 0° and 90° present a higher Nusselt number compared to that of 45° by 9.3%. The maximum thermal performance factor reached 2.12 for a twisted pitch ratio of 4.69 and coil torsion of 0.068 and at a coil inclination angle of 90°. The smooth tube predicts a higher exergy destruction rate and dimensionless exergy loss than the corrugated tube by 25% and 26.9%, respectively. New correlations to predict the Nusselt number and the friction factor were correlated.
Graphical Abstract
Holarrhena species: a review of the traditional uses, active constituents and pharmacological properties
Authors: Pawar Ganesh , Pandey Varsha , Saxena Hari Om , Yadav Anil Kumar , Dabral Aman 
Published: December 2024

AbstractMedicinal plants play a vital role in human health care and are used to cure various diseases. The genus Holarrhena is a member of the family Apocynaceae and is mainly found in tropical Africa, Southern continental Asia, and Sri Lanka. Many species of Holarrhena have traditionally been used for the treatment of various diseases, such as hallucinations, dysentery, biliousness, leprosy, tiredness, and skin problems. Importantly, the bark and its extracts have long been used in traditional medicine worldwide for their therapeutic properties. Numerous studies suggested the potential antibacterial, antifungal, anti-inflammatory, anti-diabetic, cytotoxicity, analgesic, antimalarial, antioxidant, and diuretic activity of Holarrhena against several cancer cells, and animal modal, bacterial, and fungal strains. The aim of the review of this genera is, to explore the therapeutic potential of Holarrhena species and assess future research opportunities, to provide current, thorough, and well-organized information on botany, traditional uses, phytochemistry, pharmacology, standardization report, and patent information on the plant and lastly is to compile the majority of the scientific research that has been performed in genus Holarrhena. The articles published from 1882 to 2024 were included in this review. The information about the different species of genus Holarrhena was collected through major E-databases including Google Scholar, Web of Science, Research Gate, CABI, Scopus, PubMed, Science Direct, Google Patents, Academia, and Elsevier.
Graphical Abstract
Laptop computer as instrument in music performance lessons: issues and opportunities
Authors: Iversen Kristian Tverli , Hebert David G. 
Published: December 2024

Abstract
In the 21st century, we are increasingly exposed to music created entirely on computers. This article shows how pioneering music teachers approach the challenge of teaching music on the laptop computer in the context of one-to-one musical instrument lessons. Interviews and observations with five laptop teachers in Norwegian secondary schools enabled the authors to explore characteristic challenges in this field. This study explored two research questions: What are the instructional strategies, content and ‘repertoire’ in music lessons on laptop computer? How have teachers experienced the laptop’s evolutionary process towards legitimation?
The Impact of Green Development of Industrial Parks on the Reduction of Carbon Emissions in Urban Areas—Empirical Research on Green Industrial Parks in China
Authors: Yu Xiang , Hu Wentao , Wang Mudan 
Published: December 2024

AbstractChina has over 2,500 national and provincial industrial parks, stimulating the economics growth, meanwhile being the primary sources of carbon dioxide emissions and other pollutants. Assessing the mechanisms and impacts of the policies of pilot programs of green industrial parks on urban carbon emissions offers critical insights into the efficacy and application of green and low‐carbon development. This study utilizes a staggered difference‐in‐differences model to examine the impact of green industrial park pilot policies. The results demonstrate that green industrial parks have effectively reduced carbon emissions of the studied counties in terms of total and intensity. The economic scales and the administrative levels of any given city significantly influence the implementation effect of green industrial park policy. In applying the green industrial park policy, reducing the carbon emissions is more pronounced in cities with larger economic scales and higher administrative levels. Environmental regulation policies and green industrial park pilot policies exhibit a certain degree of substitution effect. The green industrial parks drive urban carbon emission reduction through three main channels: enhancing green technologies, optimizing industrial structures, and elevating economic agglomeration levels. Overall, this study provides a new perspective, a methodological reference, and empirical evidence for promoting green and low‐carbon development for industrial parks in the different regions and developing countries.