bluuebunny/crossref_metadata_2025_split huggingface dataset:
The aggrephagy-related gene TUBA1B influences clinical outcomes in glioma patients by regulating the cell cycle
Authors: Sun Zesheng , Huang Pengcheng , Lin Jialiang , Jiang Guiping , Chen Jian , Liu Qianqian 
Published: February 2025

BackgroundGliomas are common primary malignant brain tumors, with glioblastoma (GBM) being the most aggressive subtype. GBM is characterized by high recurrence rates and treatment resistance, leading to poor patient outcomes. Current prognostic models have limited predictive power, underscoring the need to elucidate underlying mechanisms and identify novel biomarkers to improve therapeutic strategies and prognostic models.MethodsGene expression and clinical data for GBM and LGG were obtained from the TCGA and CGGA database, while single-cell sequencing data from GSE167960 were selected from the GEO database. Molecular characteristics of gliomas were revealed through normalization, consensus clustering analysis, immune scoring, cell infiltration analysis, and pathway analysis. TUBA1B, identified as a key gene through machine learning, was incorporated into a nomogram model using multivariate Cox regression. Its functions were validated through qRT-PCR, in vitro functional assays, and mouse xenograft models. All data analyses and statistics were performed using R software.ResultsConsensus clustering of the TCGA glioma dataset identified two aggrephagy subtypes (C1 and C2), with C2 showing worse survival outcomes and higher immune infiltration. TUBA1B was identified as an independent prognostic marker, with high expression associated with upregulated cell cycle pathways and alterations in the immune microenvironment. TUBA1B was shown to influence glioma cell proliferation, migration, invasion, and autophagy, impacting tumor progression and treatment response through intercellular communication and metabolic pathways.ConclusionThe study demonstrates that high TUBA1B expression is closely associated with glioma malignancy and poor prognosis, making it a potential therapeutic target.
Exogenous Galectin-9 prevents peri-implantitis in rats by regulating macrophage polarization
Authors: Cheng Lujin , Ji Xiaowei , Yilihamujiang Huerxidai , Dong Shuya , Mei Long , Lin Guo , Tang Qihan , Gong Zhongcheng 
Published: February 2025

BackgroundPeri-implantitis (PI) is a common complication of oral implants with no definitive treatment strategy. Lipopolysaccharides (LPS) are involved in PI by activating macrophages and influencing osteoclasts and osteoblasts. Galactin-9 (Gal-9) is known for its immunomodulatory properties and interactions with macrophage polarization receptors. This study investigated the mechanism of prophylactic exogenous Gal-9 in the prevention and treatment of PI in rats.MethodsMale SD rats with titanium implants were divided into the Control, Saline, and Gal-9 groups. Rats in the Saline group and Gal-9 group were prophylactically administered Gal-9 and Saline, respectively, before inducing PI. Periodontal examinations, X-ray imaging, flow cytometry analyses, and micro-CT evaluations were conducted to assess clinical, imaging, and immunological parameters.ResultsAfter inducing PI, the implant loss rate in the Gal-9 group was lower than that in the Saline group. The gingival index was higher in the Saline group and Gal-9 group compared to the Control group. The bleeding on probing positivity rate was higher in the Saline group than in the other two groups. X-ray and micro-CT images both showed lower alveolar bone resorption in the Gal-9 group than in the Saline group. Flow cytometry showed that the proportions of M1-type macrophages and M2-type macrophages, and M1/M2 ratio were lower in the Gal-9 group than those in the Saline group. Multivariate linear regression indicated that Tb.Th had the greatest impact on the gingival index and Tb.Sp had the greatest impact on the M1/M2 ratio.ConclusionExogenous Gal-9 administration demonstrated promising effects in mitigating inflammation associated with PI in rat models by promoting M2 macrophage polarization and enhancing alveolar bone stability.
Asperosaponin VI suppresses ferroptosis in chondrocytes and ameliorates osteoarthritis by modulating the Nrf2/GPX4/HO-1 signaling pathway
Authors: Zhang Zhimeng , Yuan Daotong , Jin Ximin , Chang Wenjie , Zhang Yongkui , Xie Wenpeng 
Published: February 2025

BackgroundAsperosaponin VI (AVI) is a naturally occurring monosaccharide derived from Dipsacus asperoides renowned for its anti-inflammatory and bone-protective properties.ObjectiveTo elucidate the specific mechanism through which AVI affects chondrocytes in osteoarthritis (OA).MethodsFor the in vitro experiments, primary chondrocytes were to elucidate the molecular mechanisms underlying the action of AVI.For the in vivo experiments, rat OA models were established using a modified Hulth method. The severity of knee osteoarthritis was evaluated 8 weeks post-surgery. Micro-CT imaging, hematoxylin-eosin staining, and Safranin O-fast green staining were used to assess degeneration in rat knee joints. Immunohistochemistry techniques were conducted to measure the levels of collagen II, MMP13, Nrf2, GPX4, ACSL4, and HO-1 within cartilage tissues. ELISA assays were performed to measure those of TNF-α, IL -6, and PGE2 in serum samples.ResultsAVI alleviated chondrocyte apoptosis and extracellular matrix degradation in rat OA induced by IL-1β. It attenuated the levels of TNF-α, IL-6, and PGE2 while reducing those of Fe2+ and malondialdehyde (MDA). AVI upregulated the expression of Nrf2, HO-1, and GPX4 while downregulating that of ACSL4. Mechanistic studies revealed that ML385-induced inhibition of the Nrf2 signaling pathway reversed the increase in GPX4 and ACSL4 expression and increased Fe2+ and MDA levels; treatment with erastin, a ferroptosis inducer, produced comparable results. In vivo experiments demonstrated that AVI improved the bone volume/tissue volume and trabecular separation values in OA rats; reversed the Osteoarthritis Research Society International score; upregulated Nrf2, HO-1, and GPX4 expression; downregulated ACSL4 and MMP13 expression, and decreased the serum levels of TNF-α, IL-6, and PGE2.ConclusionOur findings suggest that AVI is a promising therapeutic agent for OA. It exerted its protective effect by regulating the Nrf2/GPX4/HO-1 signaling axis to inhibit cartilage cell ferroptosis and improve osteoarthritis.
Media addiction in children and adolescents—a study protocol for development, piloting and evaluation of a sustainable, integrative rehabilitation program (MeKi)
Authors: Fahrenkrog S. , Rittmann L. M. , Klüpfel L. , Delfs S. , Stumm J. 
Published: February 2025

IntroductionThe proportion of children and young people in Germany who have problematic media use has increased, particularly as a result of the coronavirus pandemic. The presence of comorbidities such as anxiety disorders, depression, sleep disorders, impulsivity and lack of social skills are interdependent with media addiction. Medical rehabilitation is suitable for the long-term care of children and adolescents with media addiction. As part of the MeKi study, a rehabilitation program for children and adolescents with media addiction is being developed and piloted in a cooperating rehabilitation clinic. The trial is registered under DRKS-ID: DRKS00034461, Medienabhängigkeit bei Kindern und Jugendlichen—Entwicklung, Pilotierung und Evaluation eines nachhaltigen, integrativen Rehabilitationskonzepts.Methodes and analysisAs part of a mixed methods design a multimodal rehabilitation concept for children and adolescents with media addiction will be developed in a preparation phase based on the results of a scoping review as well as interviews and focus groups with affected children and adolescents, their parents and experts. In a trial phase the concept will be implemented with a planned sample of 80 Children and adolescents over a period of 1.5 years and evaluated by means of a results evaluation using a questionnaire survey and a process evaluation using interviews and focus groups.DiscussionThe lack of a standardized definition for problematic media use in children and adolescents complicates both the scientific discourse and the practical care of those affected. Furthermore, there are currently only a few therapeutic offers and these are only available in the acute sector. The development and piloting of a rehabilitation program for children and adolescents with media addiction is intended to provide sustainable rehabilitative care, which is to be transferred to other clinics after the end of the project.Trial registrationThe trial is registered under DRKS-ID: DRKS00034461, Medienabhängigkeit bei Kindern und Jugendlichen—Entwicklung, Pilotierung und Evaluation eines nachhaltigen, integrativen Rehabilitationskonzepts.
Techniques for Compiling Input-Output Tables to Measure the Impact of the Digital Economy in Russia
Authors: Glinskiy V. V. , Serga L. K. , Yushina K. S. , Varnavskiy E. A. 
Published: February 2025

As global digital transformation unfolds, analyzing the effects of digital technologies on economics is increasingly important. The choice of better methods and tools for assessing the contribution of digitalization requires further in-depth research. This paper focuses on developing a methodology for measuring the following key indicators of the digital economy, such as development level, dynamics, and linkages between sectors in the context of structural changes in production and consumption at the industry level. The basis of the proposed solution lies in using matrices of coefficients of direct and full material costs obtained based on the Input-Output tables.Using the data from 2016 to 2020 for the Russian Federation, the authors conducted calculations and identified the economic activities most affected by digital transformation. The developed methodology makes it possible to measure the contribution of the digital economy based on the inter-industry balance, identify key sectors, and propose measures to stimulate digitalization processes. The results of the study can inform managerial decision-making at the country, regional, and industry levels. Open data from the Federal State Statistics Service (Rosstat) served as the information basis of the study.
Пожарная обстановка в лесах юга Дальнего Востока на примере Хабаровского и Приморского краев
Authors: Орлов А.М. , Андреев Ю.А. , Чаков В.В. , Позднякова В.В. , Громыко О.С. , Грищенова Ю.А. 
Published: February 2025

В статье рассмотрены актуальные вопросы, касающиеся лесопожарной обстановки на юге Дальнего Востока, для которого характерны высокая продолжительность пожароопасного сезона и пики пожарной опасности. В качестве исходных данных использовались сведения федеральной и отраслевой статистики, отчеты органов государственного управления, научные публикации, а также собственные исследования авторов. Приведен анализ причин возникновения пожаров, их количества и площадей, продолжительности пожароопасного сезона, пространственного (географического) распределения за последние несколько лет на примере Приморского и Хабаровского краев. Учитывая разнообразие экономических, природно-климатических и лесорастительных условий анализ пожарной опасности производился в сравнении не только между двумя субъектами, но и между лесными районами, входящими в них – Дальневосточным таежным и Приамурско-Приморским хвойно-широколиственным. По результатам анализа сформулированы предложения по планированию профилактических противопожарных мероприятий, направленные на снижение горимости в этих субъектах.
The article discusses current issues related to the forest fire situation in the south of the Far East. The initial data used was federal and industry statistics, reports from government agencies, scientific publications, as well as the authors’ own research. An analysis of the causes of fires, their number and area, the duration of the fire season, spatial (geographic) distribution over the past few years is provided using the example of the Primorsky and Khabarovsk territories. Taking into account the diversity of economic, natural-climatic and forest conditions, fire hazard analysis was carried out in comparison not only between the two subjects, but also between the forest areas included in them - the Far Eastern taiga and the Amur-Primorsky coniferous-deciduous. Based on the results of the analysis, proposals were formulated for planning preventive fire prevention measures aimed at reducing fire rates in these regions.
Управление процессом определения рационального обеспечения подразделений МЧС России, расположенных на территории Арктической зоны РФ
Authors: Смирнов А.С. , Балобанов А.А. , Новиков В.Р. , Пряничников А.В. 
Published: February 2025

Проблема обеспечения защищенности населения и территорий Арктической зоны Российской Федерации в настоящее время стоит крайне остро, поскольку данный регион имеет стратегически и экономически важное значение. Инфраструктура, позволяющая обеспечивать безопасность на данной территории должна отвечать высоким требованиям и стандартам, что обусловлено тяжелыми климатическими условиями региона. В статье рассматривается подход к разработке системы критериев и показателей определения рационального состава комплекса техники, технических средств, оборудования, имущества, экипировки и снаряжения, обеспечивающего наиболее эффективное выполнение всего спектра задач подразделениями МЧС России в условиях Арктической зоны Российской Федерации. В рамках представленной статьи рассматривается пример определения оптимального состава техники. Представлен алгоритм выделения существенных показателем и продемонстрирован пример практического применения данного алгоритма.
The problem of ensuring the protection of the population and territories of the Arctic zone of the Russian Federation is currently extremely acute, since this region is strategically and economically important. The infrastructure to ensure security in this area must meet high requirements and standards, due to the harsh climatic conditions of the region. The article considers an approach to the development of a system of criteria and indicators for determining the rational composition of a complex of equipment, technical means, equipment, property, equipment and equipment that ensures the most effective performance of the entire range of tasks by units of the Ministry of Emergency Situations of Russia in the Arctic zone of the Russian Federation. An algorithm for identifying significant indicators is presented and an example of practical application of this algorithm is demonstrated.
Persuasive Communication Strategy in Preventing Child Marriage through the Marriage Age Maturation Program in Sirau Village, Purbalingga Regency
Authors: Mumtingah Suciarti , Iman Sulaiman Adhi , Prastyanti Shinta 
Published: February 2025

The purpose of this study is to persuasive communication strategy in preventing child marriage through the marriage age maturation program. This research is qualitative research that used the constructivism paradigm. The research was located in Sirau Village, Karangmoncol District, Purbalingga Regency. The selected unit of analysis is the implementation of the Marriage Age Maturation (PUP) program in Sirau Village, Purbalingga Regency. There are two types of data used in this research, namely primary data and secondary data. The primary data used are the results of observations and in-depth interviews. Secondary data from this research were obtained through library research and literature relevant to the research. The persuasive communication strategy carried out by BKKBN through the Marriage Age Maturation (PUP) program can be seen from activity groups in the form of Youth Family Development (BKR) and the Youth Counseling Information Center (PIK-R), Qualified Family Planning (PKB) instructors through clear message and creative media.
Pemberian Bawang Merah terhadap Demam pada Bayi
Authors: Veronica Septika Yani , Yane Ade , Sakdiah Anita , Komalasari Komalasari 
Published: February 2025

Purpose: The Infant Mortality Rate (AKB) shows that neonatal health services in a country are not good. (Ministry of Health, 2017). Baby health problems are one of the main problems in the field of health. Fever is a condition of an increase in body temperature above normal. This covetous obstetric care that focuses on the upbringing of babies is by providing onion compress interventions in feverish babies aimed at reducing fever in infants.
Research Methodology: This study is a case study with the subjects of 3 babies who had a fever, the intervention was given on day 1 of fever until day 3.
Result: The results of the study were obtained from 3 babies who had a fever by being given onion compress interventions to experience a decrease in temperature on day 1 to day 3. It can be concluded that shallots are effective against a decrease in body temperature in feverish toddlers. For health workers, in order to be able to cooperate with Puskesmas in creating an evidence-based care program for mothers who have babies and toddlers that can increase maternal understanding so that they can apply complementary therapy onion compresses as an alternative herbal medicine that can reduce body temperature in newborns and toddlers with fever.
Representasi Visual Obyek Wisata Lawang Sewu, Semarang dalam Media Promosi
Authors: Ashila Muhammad Hanif 
Published: February 2025

Lawang Sewu merupakan destinasi wisata ikonik di Kota Semarang yang memiliki nilai sejarah dan arsitektur yang signifikan. Penelitian ini bertujuan untuk menganalisis representasi visual Lawang Sewu dalam media promosi digital guna meningkatkan daya tarik wisatawan. Dengan pendekatan kualitatif deskriptif, data dikumpulkan melalui studi literatur, observasi media digital, serta analisis visual terhadap fotografi, sketsa, ilustrasi, dan lukisan naturalis. Hasil penelitian menunjukkan bahwa elemen visual seperti komposisi, warna, perspektif, dan pencahayaan memainkan peran penting dalam membangun daya tarik estetika dan narasi budaya Lawang Sewu. Media promosi digital yang efektif tidak hanya meningkatkan kesadaran terhadap destinasi ini tetapi juga memperkuat identitasnya sebagai simbol sejarah dan kebanggaan Kota Semarang. Rekomendasi strategis disajikan untuk mengoptimalkan promosi visual di era digital.
Konstruksi dan Analisis r-Ideal di BG-aljabar
Authors: Beauty Meivy Andhika , Gemawati Sri , Deswita Leli 
Published: February 2025

A non-empty set G with a binary operation ∗ and a constant 0 that satisfies the following axioms: , , and for all is called a BG-algebra. A non-empty subset I of G is said to be an ideal in G if it satisfies: (i) and (ii) and implies for all . This article introduces the new concept of r-ideal in BG-algebra, which is an extension of the ideal in BN-algebra. Unlike the definition of an ideal in BN-algebra, an r-ideal only requires a non-empty subset I of G without the need to satisfy the full ideal conditions. This study examines the properties of r-ideals and their relationships with subalgebras, normal, and ideals in BG-algebra. In the final part, it is concluded that every subalgebra is an r-ideal in BG-algebra, and every normal ideal is also an r-ideal.
Using Detailed Single-star and Binary-evolution Models to Probe the Large Observed Luminosity Spread of Red Supergiants in Young Open Star Clusters
Authors: Wang Chen , Patrick Lee , Schootemeijer Abel , de Mink Selma E. , Langer Norbert , Britavskiy Nikolay , Xu Xiao-Tian , Bodensteiner Julia , Laplace Eva , Valli Ruggero , Vigna-Gómez Alejandro , Klencki Jakub , Justham Stephen , Johnston Cole , Ma Jing-ze 
Published: February 2025

Abstract
Red supergiants (RSGs) represent a late evolutionary stage of massive stars. Recent observations reveal that the observed luminosity range of RSGs in young open clusters is wider than expected from single-star evolution models. Binary evolution effects have been suggested as a possible explanation. Here, we analyze 3670 detailed binary-evolution models, as well as corresponding single-star models, to probe the contribution of binary mass transfer and binary mergers to the luminosity distribution of RSGs in star clusters with ages up to 100 Myr. We confirm that the expected luminosity range of RSGs in a coeval population can span a factor of 10, as a consequence of mergers between two main-sequence stars, which reproduces the observed RSG luminosity ranges in rich clusters well. While the luminosity increase as consequence of mass transfer is more limited, it may help to increase the number of overluminous RSGs. However, our results also demonstrate that binary effects alone are insufficient to account for the number of RSGs found with luminosities of up to 3 times those predicted by current single-star models. We discuss observational accuracy, rotational mixing, age spread, and intrinsic RSG variability as possible explanations. Further observations of RSGs in young open clusters, in particular studies of their intrinsic brightness variability, appear crucial for disentangling these effects.
Is the Spin of the Black Hole in GX 339–4 Negative?
Authors: Zdziarski Andrzej A. , Banerjee Srimanta , Szanecki Michał , Misra Ranjeev , Dewangan Gulab 
Published: February 2025

Abstract
We have studied the accreting black hole binary GX 339–4 using two highly accurate broadband X-ray data sets in very soft spectral states from simultaneous NICER and NuSTAR observations. Joint fitting of both data sets with relativistic models of the disk and its Comptonization and reflection allows us to relatively accurately determine the black hole mass, spin, distance, and inclination. However, we find that the measured values strongly depend on the used disk model. With widely used Kerr disk models treating departures from local blackbody spectra using color corrections, we find relatively low black hole masses and strongly negative spins (i.e., retrograde accretion). Then, models employing radiative transfer calculations of the disk atmosphere predict moderately positive spins and high masses. When adding a warm corona above the disk (as proposed before for both active galactic nuclei and accreting binaries), we find that the spin is weakly constrained but consistent with zero. In all cases, the fitted inclination is low, ≈30°–34°. For the spin axis aligned with the binary axis, the mass function for this source implies large values of the mass, consistent only with those obtained with either disk-atmosphere models or the presence of a warm corona. We also test different disk models for an assumed set of mass, distance, and inclination. We find that different models yield values of the spin parameter differing by up to ∼0.3. Our results confirm previously found strong model dependencies of the measured black hole spin, now by comparing different disk models and for a low-mass X-ray binary.