bluuebunny/crossref_metadata_2025_split huggingface dataset:
Minimal Spiking Neuron for Solving Multilabel Classification Tasks
Authors: Fil Jakub , Chu Dominique 
Published: May 2020

The multispike tempotron (MST) is a powersul, single spiking neuron model that can solve complex supervised classification tasks. It is also internally complex, computationally expensive to evaluate, and unsuitable for neuromorphic hardware. Here we aim to understand whether it is possible to simplify the MST model while retaining its ability to learn and process information. To this end, we introduce a family of generalized neuron models (GNMs) that are a special case of the spike response model and much simpler and cheaper to simulate than the MST. We find that over a wide range of parameters, the GNM can learn at least as well as the MST does. We identify the temporal autocorrelation of the membrane potential as the most important ingredient of the GNM that enables it to classify multiple spatiotemporal patterns. We also interpret the GNM as a chemical system, thus conceptually bridging computation by neural networks with molecular information processing. We conclude the letter by proposing alternative training approaches for the GNM, including error trace learning and error backpropagation.
Introducing Key Elements Regarding Access to Personal Data for Scientific Research in the Perspective of Developing Innovative Medicines
Authors: Herveg Jean , Altavilla Annagrazia 
Published: May 2020

Abstract
This article aims at opening discussions and promoting future research about key elements that should be taken into account when considering new ways to organise access to personal data for scientific research in the perspective of developing innovative medicines. It provides an overview of these key elements: the different ways of accessing data, the theory of the essential facilities, the Regulation on the Free Flow of Non-personal Data, the Directive on Open Data and the re-use of public sector information, and the General Data Protection Regulation (GDPR) rules on accessing personal data for scientific research. In the perspective of fostering research, promoting innovative medicines, and having all the raw data centralised in big databases localised in Europe, we suggest to further investigate the possibility to find acceptable and balanced solutions with complete respect of fundamental rights, as well as for private life and data protection.
Interactions between International Organizations
Authors: Gött Henner 
Published: May 2020

Interactions between international organizations (‘IOs’) are a ubiquitous and multifaceted phenomenon in global governance, with labour governance being an important field of reference. Such inter-organizational interactions, defined as intended or accidental influence between IOs, can considerably affect the way in which the interacting IOs execute their respective mandates. Depending on the situation, inter-organizational interactions can increase IOs’ outreach and impact, but they can also dilute, divert or thwart their activities and their functioning.
Against this background, it is surprising that international legal scholarship has so far shown little interest in the legal dimensions of inter-organizational interactions. In consequence, many central aspects of the law governing such interactions still lay obscure. This article argues that there is a need for international lawyers to examine the phenomenon and the legal implications of inter-organizational interactions in a systematic manner. Using interactions between the International Labour Organization and the UN, the International Maritime Organization, the World Bank and the European Court of Human Rights as examples, this article explores the phenomenon of inter-organizational interactions, extrapolates these interactions’ variety, impact and normative ambivalence, and develops a legal scholarly perspective on them. In doing so, the article expounds the research agenda for a systematic legal analysis of inter-organizational interactions in labour governance and beyond.
Life at Play
Authors: Qader Nasrin 
Published: May 2020

Abstract
Asef Soltanzadah is one of the most thought-provoking Afghan writers. His work, set exclusively during wartime, may be characterized by both seriousness and playfulness. To borrow Warren Motte’s words, “playing in earnest” is his literary signature. Yet, he occupies a marginal place within the institution of world literature not only because he writes in Persian but also because he is minimally translated and read. In this article, I turn to two of his short stories featuring a game of cards and kite flying, setting them into conversation with theories of play. I argue that by creating a space for play, Soltanzadah brings into visibility and reflects on the process, promise and risk of transforming mere life into life world within the time and space of war, challenging the theoretical framing of play in relation to the real world while questioning the possibility of worlding in the time of war.
Visual Surplus of Seeing Play in ece: Beyond the Ontologic Trap?
Authors: WHITE E. Jayne 
Published: May 2020

Abstract
Play holds a precarious status in early childhood education curriculum and even more so in pedagogy. Misaligned with adult-ceatred discourses that seek to name and frame learning according to established curriculum ideals, the educators’ quest is to capture evidence of leaving in an ontologic trap that binds teachers in the service of the state and its priorities. Yet, an increasing body of dialogically inspired research seeks to suspend such authoritative strongholds by revealing the nuanced state of play that exceeds such framings. In this paper the dialogic notion of visual surplus is specifically exploited through the deployment of 360 degree footage filmed in an ece centre, and dialogues about what is seen, generated as part of a larger study. Through such excess playful encounters with and about young learners – often in spite of, not because of, well-meaning adult interventions – make a mockery of those claims that are made by adults through their play. Instead, a democratic agenda is set for play as a series of alteric as well as agentic events that lay bare the trap and attempt to escape it.
Low back pain in athletes can be controlled with acupuncture by a catecholaminergic pathway: clinical trial
Authors: Arriaga-Pizano Lourdes , Gómez-Jiménez Daniel Cuauhtémoc , Flores-Mejía Luis Angel , Pérez-Cervera Yobana , Solórzano-Mata Carlos Josué , López-Macías Constantino , Isibasi Armando , Torres-Rosas Rafael 
Published: May 2020

Background: Activation of the sympathetic nervous system attenuates inflammation via catecholamines. Recent evidence has shown that electroacupuncture (EA) activates neuronal networks involved in the release of dopamine and norepinephrine that control systemic inflammation. In muscle, catecholamines are related to cyclic adenosine monophosphate (cAMP). This signaling molecule has been implicated in recovery from sustained contractile activity, which may induce muscular pain, such as that which occurs during low back pain (LBP). Objective: Our aim was to evaluate the effects of EA used for the control of LBP on the activation of the sympathetic nervous system in a randomized controlled clinical trial in athletes. Methods: Two groups of athletes with acute or chronic low back pain were studied. EA, sham EA and pharmacological treatment (diclofenac sodium) were evaluated. The outcome measures included a pain score represented by a visual analogue scale (VAS) and serum levels of catecholamines quantified by enzyme-linked immunosorbent assay. In addition, blood was collected into chilled heparin tubes, placed in 96-well cell culture plates and incubated with an equal volume of Roswell Park Memorial Institute (RPMI) medium, with lipopolysaccharide (LPS) alone or with catecholamines. Tumor necrosis factor (TNF)-α levels in the supernatants were analyzed. Results: The results indicated that the initial pain ratings did not differ between the groups analyzed. EA induced epinephrine secretion but not norepinephrine or dopamine secretion. Although EA and pharmacological treatment did not differ in terms of pain relief, in vitro epinephrine and norepinephrine reduced TNF-α production in response to LPS stimuli. Conclusion: EA activates the sympathetic nervous system and induces the release of epinephrine, which could ameliorate inflammation and protect muscular tissue in addition to relieving pain.
Innovation and Economic Growth in Sub-Saharan Africa: Why Institutions Matter? An Empirical Study Aross 37 Countries
Authors: Bekana Dejene Mamo 
Published: May 2020

Based on empirical panel data for a sample of 37 sub-Saharan African economies for 1996–2016, this inquiry examines the extent to which institutional quality explains the existing cross-country difference in economic performance in sub-Saharan Africa. While most of the existing studies focus only on the direct effect of institutional quality, this article investigates the direct and indirect effects of institutions. It also reflects on impact of the interaction between institutional quality and innovation on economic growth in developing countries. The evidence provides very strong support for the direct effect of institutional quality development on economic performance as well as for its indirect effect via its impact on innovation. However, the results do not support theories that argue in favour of interaction between institutional quality such as democracy, governance quality and innovation, thereby pointing to the need for better calibration of the numerous existing theoretical postulations and related empirical measures. JEL: D70, D72, O15, O30, O31, O55
Association Between Mothers’ Alcohol Use Histories and Deficient Parenting in an Economically Disadvantaged Sample
Authors: Taber-Thomas Sarah M. , Knutson John F. 
Published: May 2020

Objective: Problematic maternal alcohol use confers risk for child maltreatment, though the effect on specific aspects of parenting is unclear. This study examined concurrent and prospective links among maternal alcohol use history, care neglect, supervisory neglect, and harsh or inconsistent discipline. Method: Multimethod multisource data were utilized to assess deficient parenting in 311 economically disadvantaged mothers at high risk of child maltreatment. Structural equation modeling was used to test hypothesized relations. Results: Maternal history of alcohol use was associated with more inconsistent discipline and higher levels of subsequent supervisory neglect. Secondary analyses among two-parent families found that paternal substance misuse was associated with maternal care neglect and poor supervision. Conclusions: Among low socioeconomic status families, maternal alcohol use increases the risk of inconsistent discipline and inadequate supervision. Inconsistent discipline may also lead to punitive parenting practices. Given the potential effect of paternal substance use on maternal parenting, findings highlight the importance of screening all caregivers for substance use in child welfare and research contexts to clarify when and how to intervene most effectively.
Near-infrared transmitting occlusive intraocular lens implantation for intractable diplopia: Report of two cases
Authors: Palma-Carvajal Francisco , Wróbel-Dudzińska Dominika , Zebdeh Abdulah , Visa Josep , Güell José Luis , Elies Daniel 
Published: May 2020

Objective: The objective of this article is to report two cases of black occlusive intraocular lens and implantation for treating intractable diplopia. Case descriptions: Two patients with intractable diplopia after orbitofacial, trauma, and surgical removal of pituitary adenoma failed to conservative management. After uneventful cataract, phacoemulsification, a black intraocular lens was implanted in every case. In both cases, a complete degree of satisfaction was achieved, with no symptoms of diplopia, and no complications have been observed in their follow-up. The use of optical coherence tomography has been possible in both cases to assess the macula and optic nerve, since a fundoscopy is not possible in such cases. Conclusion: Implantation of a near-infrared transmitting occlusive intraocular lens for treating intractable diplopia provided a complete resolution of symptoms without eliminating the possibility of examining macula and optic nerve using optical coherence tomography.
Limb-Based Patency After Surgical vs Endovascular Revascularization in Patients with Chronic Limb-Threatening Ischemia
Authors: Utsunomiya Makoto , Takahara Mitsuyoshi , Iida Osamu , Soga Yoshimitsu , Hata Yosuke , Shiraki Tatsuya , Nagae Ayumu , Kato Tamon , Kobayashi Norihiro , Suematsu Nobuhiro , Tasaki Junichi , Horie Kazunori , Uchida Daiki , Kodama Akio , Azuma Nobuyoshi , Nakamura Masato 
Published: May 2020

Purpose: To determine whether limb-based patency (LBP) after infrainguinal revascularization for chronic limb-threatening ischemia (CLTI) is similar between bypass surgery and endovascular therapy (EVT). Materials and Methods: The database for the Surgical Reconstruction vs Peripheral Intervention in Patients With Critical Limb Ischemia (SPINACH) study was interrogated to identify 130 patients (mean age 73±8 years; 94 men) who underwent bypass surgery and 271 patients (mean age 74±10 years; 178 men) who underwent EVT alone. Skin perfusion pressure (SPP) and the ankle-brachial index (ABI) were measured before the procedure and at 0, 1, and 3 months after revascularization. The outcome measure was hemodynamically evaluated LBP (SPP ≥10 mm Hg or ABI ≥0.1) maintained over the first 3 months after treatment. Any reintervention or major amputation was regarded as loss of LBP. The associations between the revascularization strategy (bypass vs EVT) and between the preoperative characteristics and the study outcome (ie, SPP- or ABI-based LBP), were determined using generalized linear mixed models with a logit link function. Patency rates are presented with the 95% confidence interval (CI). Results: The bypass surgery group had a higher stage of limb severity (WIfI) and anatomic complexity (GLASS) than the EVT group, whereas the EVT group had a higher prevalence of heart failure. Both SPP- and ABI-based LBP rates were higher in the bypass group than in the EVT group. SPP-based LBP rates at 3 months were 73.8% (95% CI 63.4% to 84.2%) in the bypass group and 46.2% (95% CI 38.5% to 53.8%) in the EVT group; the corresponding ABI-based LBP rates were 71.5% (95% CI 61.8% to 81.2%) and 44.0% (95% CI 37.3% to 50.7%). Conclusion: LBP is an important concept in the new global vascular guidelines for assessing the anatomic and hemodynamic status of CLTI patients. The present study found that LBP was significantly lower in the EVT group vs the bypass surgery group.
Technical Aspects of Branched Thoracic Arch Graft Implantation for Aortic Arch Pathologies
Authors: Spanos Konstantinos , Panuccio Giuseppe , Rohlffs Fiona , Heidemann Franziska , Tsilimparis Nikolaos , Kölbel Tilo 
Published: May 2020

Purpose: To describe the implantation steps and tips and tricks for the Inner Branch Arch Endograft designed to treat aortic arch aneurysm and chronic type A aortic dissection. Technique: Anatomical suitability criteria should be met in order to use this device. The proximal segment of the graft lands in the ascending aorta distally to the sinotubular junction and the distal segment lands in the descending aorta. The device includes 2 inner branches; the proximal branch is used for a connection to the innominate artery (positioned slightly posterior at 12:30 o’clock), while the second branch is positioned slightly anterior at 11:30 o’clock and is used as a connection to the left common carotid artery. Access, implantation technique, deployment of the device, and catheterization of the branches are described thoroughly. Conclusion: This Inner Branch Arch Endograft is an appealing alternative to treat aortic arch pathology, especially in patients unsuitable for open repair. Nevertheless, complex aortic arch repair is associated with a learning curve. Meticulous preoperative planning and a high level of concentration intraoperatively are mandatory.
Ossifying Lipoma in Costal Arches That Suggest Extensive Pulmonary Involvement: Case Report
Authors: Tobón Angélica , Silva Nhora M , Velásquez Mauricio , Morales Eliana , Sangiovanni Saveria , Fernández-Trujillo Liliana 
Published: May 2020

Background: Lipomas are the most common benign soft tissue tumors in the general population. These lesions can appear on any part of the body and usually develop in the subcutaneous superficial tissue. Lipomas that show ossifying changes are very rare, representing less than 1% of the reported lipomas. They usually manifest as hard nodular lesions in the head and neck, the extremities, the sternoclavicular region, and the subcutaneous tissue in general; they are rare in the costal arches. Case presentation: We report the case of a patient with a history of multiple diseases and 2 tumor-like lesions with internal lytic areas detected in the fourth right costal arch and in the eighth left costal arc; we describe his clinical manifestations, radiological and laboratory findings as well as the pathological results and outcome. Conclusions: Ossifying lipomas are rare benign tumors with asymptomatic clinical presentation. It is important to perform an adequate radiological differentiation from other more aggressive lesions such as liposarcomas.
Optimizing Tissue Use: A Step-wise Approach to Diagnosing Squamous Cell Lung Carcinoma on Small Biopsies
Authors: Olazagasti Coral , Preeshagul Isabel , Aziz Mohamed , Seetharamu Nagashree 
Published: May 2020

Background: Histologic subtyping of lung cancer has significant implications for treatment planning. Accurate diagnosis based on cytology/small biopsy specimens is challenging and frequently determined by morphology, as material is often not sufficient for immunohistochemical studies (IHC). We investigated the concordance between the rates of diagnosis from cytology/small biopsies compared with surgical specimens in patients with squamous cell lung cancer (SCC) and the utility of IHC for diagnostic precision in lung cancer subtyping. Methods: We conducted a 5-year retrospective analysis identifying cases of SCC diagnosed on cytology/small biopsies ± IHC and compared them with subsequent surgical specimens when available. The number of patients with SCC on surgical biopsy and the concordance between cytology ± IHC was determined. Results: Over the 5-year period (2011-2015), 231 cases were identified. Surgery was performed on 66 cases (28.5%), of which 87.9% concurred with cytological diagnosis (95% exact binomial confidence interval [CI] = 77.5%-94.6%). There were 36 cases diagnosed in 2014 and 2015 with IHC data. Of those cytology cases with IHC (n = 12), SCC was confirmed by surgery in 91.7% (95% CI = 61.5%-99.8%). Of those without IHC (n = 24), 95.8% were confirmed SCC by surgery (95% CI = 78.9%-99.9%). These rates were not different (Fisher exact test). All cases with IHC were morphologically squamous. Conclusions: Our data demonstrate that diagnostic precision of identifying SCC by cytology/small biopsy is comparable with or without additional IHC studies. We recommend judicious use of IHC on cytology specimens, reserving it for cases where cytomorphology is equivocal. Tissue should be preserved for molecular analysis, which may have therapeutic implications.
Robust CD8+ T-cell proliferation and diversification after mogamulizumab in patients with adult T-cell leukemia-lymphoma
Authors: Saito Masato , Ishii Toshihiko , Urakawa Itaru , Matsumoto Asuka , Masaki Ayako , Ito Asahi , Kusumoto Shigeru , Suzuki Susumu , Takahashi Takeshi , Morita Akimichi , Inagaki Hiroshi , Iida Shinsuke , Ishida Takashi 
Published: May 2020

Abstract
Skin-related adverse events (AEs) occur frequently in adult T-cell leukemia-lymphoma (ATL) patients treated with mogamulizumab, a humanized anti-CCR4 monoclonal antibody. This study was undertaken to elucidate the mechanisms of mogamulizumab-induced skin-related AEs. We analyzed the T-cell receptor β chain repertoire in ATL patients’ peripheral blood mononuclear cells (PBMCs) before and after mogamulizumab. Skin-related AEs were present in 16 patients and were absent in 8 patients. Additionally, we included 11 patients before and after chemotherapy without mogamulizumab. Immune-related gene expression in PBMCs before and after mogamulizumab was also assessed (n = 24). Mogamulizumab treatment resulted in CCR4+ T-cell depletion, and the consequent lymphopenia provoked homeostatic CD8+ T-cell proliferation, as evidenced by increased expressions of CD8B and CD8A, which were significantly greater in patients with skin-related AEs than in those without them. We hypothesize that proliferation is driven by the engagement of self-antigens, including skin-related antigens, in the face of regulatory T-cell depletion. Together with the observed activated antigen presentation function, this resulted in T-cell diversification that was significantly greater in patients with skin-related AEs than in those without. We found that the CD8+ T cells that proliferated and diversified after mogamulizumab treatment were almost entirely newly emerged clones. There was an inverse relationship between the degree of CCR4+ T-cell depletion and increased CD8+ T-cell proliferation and diversification. Thus, lymphocyte-depleting mogamulizumab treatment provokes homeostatic CD8+ T-cell proliferation predominantly of newly emerging clones, some of which could have important roles in the pathogenesis of mogamulizumab-induced skin-related AEs.
An integrative investigation on significant mutations and their down-stream pathways in lung squamous cell carcinoma reveals CUL3/KEAP1/NRF2 relevant subtypes
Authors: Liu Zongang , Deng Meiyan , Wu Lin , Zhang Suning 
Published: May 2020

Abstract
Background
Molecular mechanism of lung squamous cell carcinoma (LUSC) remains poorly understood, hampering effective targeted therapies or precision diagnosis about LUSC. We devised an integrative framework to investigate on the molecular patterns of LUSC by systematically mining the genomic, transcriptional and clinical information.

Methods
We utilized the genomics and transcriptomics data for the LUSC cohorts in The Cancer Genome Atlas.. Both kinds of omics data for 33 types of cancers were downloaded from The NCI’s Genomic Data Commons (GDC) (https://gdc.cancer.gov/about-data/publications/pancanatlas). The genomics data were processed in mutation annotation format (maf), and the transcriptomics data were determined by RNA-seq method. Mutation significance was estimated by MutSigCV. Prognosis analysis was based on the cox proportional hazards regression (Coxph) model.

Results
Significant somatic mutated genes (SMGs) like NFE2L2, RASA1 and COL11A1 and their potential down-stream pathways were recognized. Furthermore, two LUSC-specific and prognosis-meaningful subtypes were identified. Interestingly, the good prognosis subtype was enriched with mutations in CUL3/KEAP1/NRF2 pathway and with markedly suppressed expressions of multiple down-stream pathways like epithelial mesenchymal transition. The subtypes were verified by the other two cohorts. Additionally, primarily regulated down-stream elements of different SMGs were also estimated. NFE2L2, KEAP1 and RASA1 mutations showed remarkable effects on the subtype-determinant gene expressions, especially for the inflammatory relevant genes.

Conclusions
This study supplies valuable references on potential down-stream processes of SMGs and an alternative way to classify LUSC.