bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changement linguistique et périodisation du français (pré)classique: deux études de cas à partir des corpus du RCFC
Authors: Amatuzzi Antonella , Ayres-Bennett Wendy , Gerstenberg Annette , Schøsler Lene , Skupien-Dekens Carine 
Published: April 2020

RÉSUMÉCette étude propose d’explorer et d’identifier des moments particuliers où le changement linguistique se produit, afin de confirmer ou de rejeter l’idée d’une période spécifique désignée par le terme « français préclassique », avec une rupture – ou frontière chronolectale – détectable autour de 1630 (cf. Ayres-Bennett et Caron, 2016). Afin de vérifier dans quelle mesure cette chronologie peut être confirmée, il est nécessaire de multiplier des analyses fines et pointues sur des traits linguistiques qui ont subi des changements à l’époque en question et d’interroger une gamme de textes qui reflètent la variation discursive et pragmatique, au lieu de consulter le canon des traditions textuelles actuellement disponibles sur des bases numérisées, qui sont essentiellement littéraires. C’est pourquoi nous avons consulté des sources de nature différente, qui pourraient attester des usages émergents, à savoir les corpus du Réseau Corpus Français Préclassique et Classique (RCFC). Seront présentés les résultats de deux études de cas (la recatégorisation des formesdedans/dessous/dessus/dehorset la montée des clitiques), abondamment discutés par les remarqueurs.
3D advanced imaging overlay with rapid registration in CHD to reduce radiation and assist cardiac catheterisation interventions
Authors: Arar Yousef , Reddy Surendranath R. Veeram , Kim Heidi , Dimas V. Vivian , Zellers Thomas M. , Abou Zahr Riad , Vamsee Ravi , Greer Joshua S. , Tandon Animesh , Pontiki Antonia , Dillenbeck Jeanne , Zabala Luis , Greil Gerald , Nugent Alan W. , Hussain Tarique 
Published: April 2020

AbstractNovel commercially available software has enabled registration of both CT and MRI images to rapidly fuse with X-ray fluoroscopic imaging. We describe our initial experience performing cardiac catheterisations with the guidance of 3D imaging overlay using the VesselNavigator system (Philips Healthcare, Best, NL). A total of 33 patients with CHD were included in our study. Demographic, advanced imaging, and catheterisation data were collected between 1 December, 2016 and 31 January, 2019. We report successful use of this technology in both diagnostic and interventional cases such as placing stents and percutaneous valves, performing angioplasties, occlusion of collaterals, and guidance for lymphatic interventions. In addition, radiation exposure was markedly decreased when comparing our 10–15-year-old coarctation of the aorta stent angioplasty cohort to cases without the use of overlay technology and the most recently published national radiation dose benchmarks. No complications were encountered due to the application of overlay technology. 3D CT or MRI overlay for CHD intervention with rapid registration is feasible and aids decisions regarding access and planned angiographic angles. Operators found intraprocedural overlay fusion registration using placed vessel guidewires to be more accurate than attempts using bony structures.
How Trade-Restrictive Is Standardized Packaging? Economic and Legal Implications of the WTO Panel Reports in Australia–Tobacco Plain Packaging
Authors: Buzard Kristy , Voon Tania 
Published: April 2020

AbstractThe lengthy and long-awaited WTO Panel Reports in Australia–Tobacco Plain Packaging contain a host of material for reflection, particularly in relation to the Agreement on Technical Barriers to Trade (TBT) and the Agreement on Trade-Related Aspects of Intellectual Property Rights. While two of the Panel Reports proceed to appeal, we consider with respect to the two adopted Panel Reports the Panel's reasoning in relation to Article 2.2 of the TBT, focusing on the meaning of trade-restrictiveness. This concept central to WTO law has been under-examined to date, and these Panel Reports demonstrate some of the complexities in identifying trade-restrictive measures, particularly where they are non-discriminatory. The Panel found that Australia's measures restrict trade because they contribute to their objective of reducing tobacco consumption. Therefore, any equally effective alternative will similarly restrict trade. This curious result under TBT Article 2.2 may be particular to non-discriminatory measures that target ‘socially bad’ products such as tobacco.
Direct Surface Wave Radial Anisotropy Tomography in the Crust of the Eastern Himalayan Syntaxis
Authors: Hu Shaoqian , Yao Huajian , Huang Hui 
Published: April 2020

AbstractA novel method is implemented to invert Rayleigh and Love wave dispersion curves of all paths jointly for 3‐D shear wave velocity and radial anisotropy simultaneously without intermediate steps. We use the method to derive high‐precision crustal shear wave velocity and radial anisotropy models around the eastern Himalayan syntaxis using ambient noise dispersion data (5–40 s). Results show that the crust can be divided into several subregions with different rigidity and preferred mineral alignment orientation depth‐dependently. In the middle crust, combined with other geophysical observations, 3‐D geometry of two continuous branches of eastward channelized weak zones is outlined in detail. Both branches of the weak zone are blocked by the high velocity zone with radial anisotropy of Vsh>Vsv at around 96–97°E. In the upper crust, the radial anisotropy model depicts a complex pattern, which is associated with the ongoing surface uplifting and shear strain rate distribution.
A Sequentially Coupled Catchment‐Scale Numerical Model for Snowmelt‐Induced Soil Slope Instabilities
Authors: Siva Subramanian S. , Fan X. , Yunus A. P. , van Asch T. , Scaringi G. , Xu Q. , Dai L. , Ishikawa T. , Huang R. 
Published: April 2020

AbstractThe frequency of snowmelt‐induced soil slope instabilities is increasing in some seasonally cold regions because of climate change. Reliable hazard assessment and risk mitigation of snowmelt‐induced landslides require physically‐based prediction models. However, existing models either apply only at the slope scale or assume precipitation as the sole landslide trigger. In doing so, they neglect the complexity and coupled nature of the thermo‐hydro‐mechanical processes leading to slope instability in seasonally cold regions (such as snow accumulation and melting, infiltration and surface runoff, soil saturation, pore water pressure buildup and dissipation). Here, we present a spatially distributed and sequentially coupled numerical model to simulate snowmelt‐induced slope instabilities at the catchment scale. The model accounts for temperature‐dependent changes in the soil hydraulic behavior related to changes in water state by means of a routine implemented in a geographic information system. We verified the performance of the model using a case study of spring snowmelt‐induced soil slope failures that occurred after the 2004 Mid‐Niigata earthquake in Japan. Considering limitations and simplifications, the model was able to predict the triggering condition, magnitude, and spatial distribution of the snowmelt‐induced landslides with a satisfactory degree of accuracy. We believe that the robustness and simplicity of our numerical approach make it suitable for implementation in early warning systems.
An Alternative BEM for Simulating the Flow Behavior of a Leaky Confined Fractured Aquifer With the Use of the Semianalytical Approach
Authors: Luo Wanjing , Wang Junlei , Wang Lei , Zhou Yingfang 
Published: April 2020

AbstractThis study developed an alternative boundary element method (BEM) to simulate the transient flow behavior of groundwater induced by well extraction in a confined fractured aquifer containing a network of discrete or connected fractures. The matrix flow, network‐fracture flow, and matrix‐fracture fluid exchange were considered. The aquifer was treated as a heterogeneous whole that consisted of fracture and matrix blocks with locally homogeneous hydraulic properties. The fractures were explicitly represented to be of true finite volume rather than nonrepresentational line sources. A semianalytical solution was developed based on the theory of a BEM in the Laplace transform domain, but the analytical Green's function was used for the bounded domain rather than the free‐space Green's function in a conventional BEM. Case studies were presented in order to investigate the flow exchange behavior between the matrix and fractures and the corresponding transient drawdown response. The results showed that (1) exchange flux distribution calculated with the classical infinitesimal fracture model was consistent with the difference of the normal drawdown derivative values on both sides of the fracture body in our model. (2) When the well was in the matrix, the fractures acted as both highly conductive conduits and leaky faults, and the drawdown derivative behaviors resembled the characteristics of a dual‐porosity reservoir model. (3) When the well was in the network fracture and when the volume of fracture was of the same order of magnitude as the matrix, the drawdown derivative might exhibit the look‐alike behavior of a dual‐porosity model.
Metastability and Nondislocation‐Based Deformation Mechanisms of the Flem Eclogite in the Western Gneiss Region, Norway
Authors: Cao Yi , Du Jinxue , Park Munjae , Jung Sejin , Park Yong , Kim Dohyun , Choi Seungsoon , Jung Haemyeong , Austrheim Håkon 
Published: April 2020

AbstractThe eclogite in the Flem Gabbro from Flemsøya Island of the Western Gneiss Region in Norway contains atypical eclogitic minerals, such as olivine and orthopyroxene, and can be texturally divided into weakly deformed massive eclogite (MEC) and strongly deformed foliated eclogite (FEC). Based on phase equilibria modeling, peak metamorphic pressure‐temperature conditions of ~600–750 °C and ~1.0–2.5 GPa and ~700–820 °C and ~2.7–3.7 GPa are recorded in MEC and FEC, respectively. These different pressure‐temperature conditions between MEC (high‐pressure, HP) and FEC (ultrahigh‐pressure, UHP) in the same outcrop reflect deformation‐enhanced eclogitization metamorphism (HP to UHP transition) via the addition of external water during subduction/burial to early exhumation stages and metastable preservation of the HP MEC assemblage at UHP condition due to the local lack of deformation and fluid access at the deep subduction interface or around Moho beneath continental collision zone. Based on the mineral microstructures, nondislocation‐based creep mechanisms—such as diffusion creep, grain and phase boundary sliding, and rigid‐body‐like rotation—play dominant roles in governing the deformation features of FEC and developing the crystal preferred orientations of its major constituent minerals. These deformation mechanisms could considerably affect the interplate coupling at the subduction interface or the rheological strength of Moho beneath continental collision zones. Therefore, the effects of metastability‐based (i.e., preservation of low‐pressure assemblages at HP conditions) and contributions of nondislocation‐based creep mechanisms should be included in the future geodynamic and petrological simulations of subduction and collision processes.
Allosteric regulation accompanied by oligomeric state changes of Trypanosoma brucei GMP reductase through cystathionine-β-synthase domain
Authors: Imamura Akira , Okada Tetsuya , Mase Hikaru , Otani Takuya , Kobayashi Tomoka , Tamura Manatsu , Kubata Bruno Kilunga , Inoue Katsuaki , Rambo Robert P. , Uchiyama Susumu , Ishii Kentaro , Nishimura Shigenori , Inui Takashi 
Published: April 2020

AbstractGuanosine 5′-monophosphate reductase (GMPR) is involved in the purine salvage pathway and is conserved throughout evolution. Nonetheless, the GMPR of Trypanosoma brucei (TbGMPR) includes a unique structure known as the cystathionine-β-synthase (CBS) domain, though the role of this domain is not fully understood. Here, we show that guanine and adenine nucleotides exert positive and negative effects, respectively, on TbGMPR activity by binding allosterically to the CBS domain. The present structural analyses revealed that TbGMPR forms an octamer that shows a transition between relaxed and twisted conformations in the absence and presence of guanine nucleotides, respectively, whereas the TbGMPR octamer dissociates into two tetramers when ATP is available instead of guanine nucleotides. These findings demonstrate that the CBS domain plays a key role in the allosteric regulation of TbGMPR by facilitating the transition of its oligomeric state depending on ligand nucleotide availability.
Brain insulin sensitivity is linked to adiposity and body fat distribution
Authors: Kullmann Stephanie , Valenta Vera , Wagner Robert , Tschritter Otto , Machann Jürgen , Häring Hans-Ulrich , Preissl Hubert , Fritsche Andreas , Heni Martin 
Published: April 2020

AbstractBrain insulin action regulates eating behavior and energy fluxes throughout the body. However, numerous people are brain insulin resistant. How brain insulin responsiveness affects long-term weight and body fat composition in humans is still unknown. Here we show that high brain insulin sensitivity before lifestyle intervention associates with a more pronounced reduction in total and visceral fat during the program. High brain insulin sensitivity is also associated with less regain of fat mass during a nine year follow-up. Cross-sectionally, strong insulin responsiveness of the hypothalamus associates with less visceral fat, while subcutaneous fat is unrelated. Our results demonstrate that high brain insulin sensitivity is linked to weight loss during lifestyle intervention and associates with a favorable body fat distribution. Since visceral fat is strongly linked to diabetes, cardiovascular risk and cancer, these findings have implications beyond metabolic diseases and indicate the necessity of strategies to resolve brain insulin resistance.
A rationally enhanced red fluorescent protein expands the utility of FRET biosensors
Authors: Mo Gary C. H. , Posner Clara , Rodriguez Erik A. , Sun Tengqian , Zhang Jin 
Published: April 2020

AbstractGenetically encoded Förster Resonance Energy Transfer (FRET)-based biosensors are powerful tools to illuminate spatiotemporal regulation of cell signaling in living cells, but the utility of the red spectrum for biosensing was limited due to a lack of bright and stable red fluorescent proteins. Here, we rationally improve the photophysical characteristics of the coral-derived fluorescent protein TagRFP-T. We show that a new single-residue mutant, super-TagRFP (stagRFP) has nearly twice the molecular brightness of TagRFP-T and negligible photoactivation. stagRFP facilitates significant improvements on multiple green-red biosensors as a FRET acceptor and is an efficient FRET donor that supports red/far-red FRET biosensing. Capitalizing on the ability of stagRFP to couple with multiple FRET partners, we develop a novel multiplex method to examine the confluence of signaling activities from three kinases simultaneously in single living cells, providing evidence for a role of Src family kinases in regulating growth factor induced Akt and ERK activities.
19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis
Authors: Lasorsa Vito Alessandro , Cimmino Flora , Ognibene Marzia , Mazzocco Katia , Erminio Giovanni , Morini Martina , Conte Massimo , Iolascon Achille , Pezzolo Annalisa , Capasso Mario 
Published: April 2020

AbstractGenomic aberrations of neuroblastoma occurring in late childhood and adolescence are still understudied. Publicly available DNA copy number profiles of 556 tumors (discovery set) and of 208 tumors obtained by array-CGH assay (validation set) were used to test if 19p loss is significantly over-represented in children and adolescents with neuroblastoma. The 19p loss occurrence was separately tested within different age groups in the discovery and validation set and the resulting P values were combined by meta-analysis and corrected by Bonferroni’s method. In both sets, 19p loss was associated with older age at diagnosis. Particularly, the lowest age group significantly associated with 19p loss (discovery set: 20%; validation set: 35%) was 6 years. The 19p loss correlated with inferior overall survival in patients over 6 years of age. Relevant tumor suppressor genes (KEAP1, DNM2, SMARCA4, SLC44A2 and CDKN2D) and microRNAs (miR-181c, miR-27a, and mirR-199a-1) are located in the genomic region involved in 19p loss. Downregulation of DNM2, SLC44A2 and CDKN2D was associated with poor patient outcome and older age. Among the recurrent NB chromosomal aberrations, only 1q gain was enriched in patients older than 6, and its presence was mutually exclusive with respect to 19p loss. Our data demonstrate that 19p loss is a genomic biomarker of NB diagnosed in older children that can predict clinical outcome.
Serum albumin cysteine trioxidation is a potential oxidative stress biomarker of type 2 diabetes mellitus
Authors: Paramasivan Selvam , Adav Sunil S. , Ngan SoFong Cam , Dalan Rinkoo , Leow Melvin Khee-Shing , Ho Hee Hwa , Sze Siu Kwan 
Published: April 2020

AbstractMetabolic disorders in T2DM generate multiple sources of free radicals and oxidative stress that accelerate nonenzymatic degenerative protein modifications (DPMs) such as protein oxidation, disrupt redox signaling and physiological function, and remain a major risk factor for clinical diabetic vascular complications. In order to identify potential oxidative biomarkers in the blood plasma of patients with T2DM, we used LC-MS/MS-based proteomics to profile plasma samples from patients with T2DM and healthy controls. The results showed that human serum albumin (HSA) is damaged by irreversible cysteine trioxidation, which can be a potential oxidative stress biomarker for the early diagnosis of T2DM. The quantitative detection of site-specific thiol trioxidation is technically challenging; thus, we developed a sensitive and selective LC-MS/MS workflow that has been used to discover and quantify three unique thiol-trioxidized HSA peptides, ALVLIAFAQYLQQC(SO3H)PFEDHVK (m/z 1241.13), YIC(SO3H)ENQDSISSK (m/z 717.80) and RPC(SO3H)FSALEVDETYVPK (m/z 951.45), in 16 individual samples of healthy controls (n = 8) and individuals with diabetes (n = 8). Targeted quantitative analysis using multiple reaction monitoring mass spectrometry revealed impairment of the peptides with m/z 1241.13, m/z 717.80 and m/z 951.45, with significance (P < 0.02, P < 0.002 and P < 0.03), in individuals with diabetes. The results demonstrated that a set of three HSA thiol-trioxidized peptides, which are irreversibly oxidatively damaged in HSA in the plasma of patients with T2DM, can be important indicators and potential biomarkers of oxidative stress in T2DM.
Shut down of the South American summer monsoon during the penultimate glacial
Authors: Rodríguez-Zorro Paula A. , Ledru Marie-Pierre , Bard Edouard , Aquino-Alfonso Olga , Camejo Adriana , Daniau Anne-Laure , Favier Charly , Garcia Marta , Mineli Thays D. , Rostek Frauke , Ricardi-Branco Fresia , Sawakuchi André Oliveira , Simon Quentin , Tachikawa Kazuyo , Thouveny Nicolas 
Published: April 2020

AbstractWe analysed changes in mean annual air temperature (MAAT), vegetation and biomass burning on a long and continuous lake-peat sediment record from the Colônia basin, southeastern Brazil, examining the responses of a wet tropical rainforest over the last 180 ka. Stronger southern atmospheric circulation up to the latitude of Colônia was found for the penultimate glacial with lower temperatures than during the last glacial, while strengthening of the South American summer monsoon (SASM) circulation started during the last interglacial and progressively enhanced a longer wet summer season from 95 ka until the present. Past MAAT variations and fire history were possibly modulated by eccentricity, although with signatures which differ in average and in amplitude between the last 180 ka. Vegetation responses were driven by the interplay between the SASM and southern circulation linked to Antarctic ice volume, inferred by the presence of a cool mixed evergreen forest from 180 to 45 ka progressively replaced by a rainforest. We report cooler temperatures during the marine isotope stage 3 (MIS 3: 57-29 ka) than during the Last Glacial Maximum (LGM: 23–19 ka). Our findings show that tropical forest dynamics display different patterns than mid-latitude during the last 180 ka.
A First Comprehensive Baseline of Hydrocarbon Pollution in Gulf of Mexico Fishes
Authors: Pulster Erin L. , Gracia Adolfo , Armenteros Maickel , Toro-Farmer Gerardo , Snyder Susan M. , Carr Brigid E. , Schwaab Madison R. , Nicholson Tiffany J. , Mrowicki Justin , Murawski Steven A. 
Published: April 2020

AbstractDespite over seven decades of production and hundreds of oil spills per year, there were no comprehensive baselines for petroleum contamination in the Gulf of Mexico (GoM) prior to this study. Subsequent to the 2010Deepwater Horizon(DWH) spill, we implemented Gulf-wide fish surveys extending over seven years (2011–2018). A total of 2,503 fishes, comprised of 91 species, were sampled from 359 locations and evaluated for biliary polycyclic aromatic hydrocarbon (PAH) concentrations. The northern GoM had significantly higher total biliary PAH concentrations than the West Florida Shelf, and coastal regions off Mexico and Cuba. The highest concentrations of biliary PAH metabolites occurred in Yellowfin Tuna (Thunnus albacares), Golden Tilefish (Lopholatilus chamaeleonticeps), and Red Drum (Sciaenops ocellatus). Conversely, biliary PAH concentrations were relatively low for most other species including economically important snappers and groupers. While oil contamination in most demersal species in the north central GoM declined in the first few years following DWH, more recent increases in exposure to PAHs in some species suggest a complex interaction between multiple input sources and possible re-suspension or bioturbation of oil-contaminated sediments. This study provides the most comprehensive baselines of PAH exposure in fishes ever conducted for a large marine ecosystem.