bluuebunny/crossref_metadata_2025_split huggingface dataset:
GIARPS High-resolution Observations of T Tauri stars (GHOsT)
Authors: Gangi M. , Nisini B. , Antoniucci S. , Giannini T. , Biazzo K. , Alcalá J. M. , Frasca A. , Munari U. , Arkharov A. A. , Harutyunyan A. , Manara C. F. , Rigliaco E. , Vitali F. 
Published: August 2020

Context.Disk winds play a fundamental role in the evolution of protoplanetary systems. The complex structure and dynamics can be investigated through the emission of atomic and molecular lines detected in high-resolution optical/IR spectra of young stellar objects. Despite their great importance, however, studies connecting the atomic and molecular components are lacking so far.Aims.In the framework of the GIARPS High-resolution Observations of T Tauri stars (GHOsT) project, we aim to characterize the atomic and molecular winds in a sample of classical T Tauri stars (CTTs) of the Taurus-Auriga region, focusing on a statistical analysis of the kinematic properties of the [O I] 630 nm and H22.12μm lines and their mutual relationship.Methods.We analyzed the flux calibrated [O I] 630 nm and H22.12μm lines in a sample of 36 CTTs observed at the Telescopio NazionaleGalileowith the HARPS-N spectrograph (resolving power ofR= 115 000) and with the GIANO spectrograph (R= 50 000). We decomposed the line profiles into different kinematic Gaussian components and focused on the most frequently detected component, the narrow low-velocity (vp< 20 km s−1) component (NLVC).Results.We found that the H2line is detected in 17 sources (~50% detection rate), and [O I] is detected in all sources but one. The NLV components of the H2and [O I] emission are kinematically linked, with a strong correlation between the peak velocities and the full widths at half maximum of the two lines. Assuming that the line width is dominated by Keplerian broadening, we found that the [O I] NVLC originates from a disk region between 0.05 and 20 au and that of H2in a region from 2 and 20 au. We also found that H2is never detected in sources where [O I] originates in regions below 1 au, as well as in sources of early (~F-G) spectral type with a luminosity >1L⊙. Moreover, in seven sources, both H2and [O I] have clear blueshifted peaks and prominent [O I] high-velocity components. These components have also been detected in sources with no relevant centroid shift. Finally, we did not find any clear correlation betweenvpof the H2and [O I] NVLC and the outer disk inclination. This result is in line with previous studies.Conclusions.Our results suggest that molecular and neutral atomic emission in disk winds originate from regions that might overlap, and that the survival of molecular winds in disks strongly depends on the gas exposure to the radiation from the central star. The presence of jets does not necessarily affect the kinematics of the low-velocity winds. Our results demonstrate the potential of wide-band high-resolution spectroscopy in linking tracers of different manifestations of the same phenomenon.
KELT-17: a chemically peculiar Am star and a hot-Jupiter planet
Authors: Saffe C. , Miquelarena P. , Alacoria J. , González J. F. , Flores M. , Jaque Arancibia M. , Calvo D. , Jofré E. , Collado A. 
Published: August 2020

Context. There is very little information to be found in the literature regarding the detection of planets orbiting chemically peculiar stars.
Aims. Our aim is to determine the detailed chemical composition of the remarkable planet host star KELT-17. This object hosts a hot-Jupiter planet with 1.31 MJup detected by transits, and it is one of the more massive and rapidly rotating planet hosts seen to date. We set out to derive a complete chemical pattern for this star, in order to compare it with those of chemically peculiar stars.
Methods. We carried out a detailed abundance determination in the planet host star KELT-17 via spectral synthesis. Stellar parameters were estimated iteratively by fitting Balmer line profiles and imposing the Fe ionization balance using the SYNTHE program together with plane-parallel ATLAS12 model atmospheres. Specific opacities for an arbitrary composition and microturbulence velocity vmicro were calculated through the opacity sampling (OS) method. The abundances were determined iteratively by fitting synthetic spectra to metallic lines of 16 different chemical species using SYNTHE. The complete chemical pattern of KELT-17 was compared to the recently published average pattern of Am stars. We estimated the stellar radius using two methods: a) comparing the synthetic spectral energy distribution with the available photometric data and the Gaia parallax, and b) using a Bayesian estimation of stellar parameters using stellar isochrones.
Results. We found over-abundances of Ti, Cr, Mn, Fe, Ni, Zn, Sr, Y, Zr, and Ba, together with subsolar values of Ca and Sc. Notably, the chemical pattern agrees with those recently published for Am stars, making KELT-17 the first exoplanet host whose complete chemical pattern is unambiguously identified with this class. The stellar radius derived by two different methods agrees to each other and with those previously obtained in the literature.
Paraneoplastische reaktiv perforierende Kollagenose nach transienter akantholytischer Dermatose Grover
Authors: Jung N. , Vogt T. , Müller C. S. L. 
Published: August 2020

ZusammenfassungWir berichten über einen 90-jährigen Patienten mit Prostata-Karzinom, bei dem initial ein Morbus Grover bestand, welcher einen Wandel der klinischen Morphe hin zu einer erworbenen reaktiv perforierenden Kollagenose im Kontext eines paraneoplastischen Geschehens zeigte. Die detaillierte Pathogenese der transienten akantholytischen Dermatose Grover sowie der reaktiv perforierenden Kollagenose ist derzeit unklar. Während die reaktiv perforierende Kollagenose sporadisch in den paraneoplastischen Kontext gerückt wird, ist der Morbus Grover bisher nicht als paraneoplastische Erscheinung eingeordnet worden. Wir diskutieren die klinischen und histologischen differenzialdiagnostischen Überlegungen und empfehlen auf Basis dieser Beobachtungen bei Auftreten eines auffälligen Morbus Grover an fakultative Paraneoplasien zu denken.
Hyperprolactinemia in Acromegaly is Related to Prolactin Secretion by
Somatolactotroph Tumours
Authors: Van Laethem Delphine , Michotte Alex , Cools Wilfried , Velkeniers Brigitte , Unuane David , Andreescu C. E. , Bravenboer Bert 
Published: August 2020

AbstractThe aim of this study is to assess differences in patient characteristics,
tumour characteristics and hormone levels between acromegalic patients with
and without hyperprolactinemia. 44 patients of the University Hospital of
Brussels, Belgium with acromegaly who were diagnosed between January 2007
and July 2018 were included in this study. Nineteen patients were classified
in the hyperprolactinemia group and 25 patients were classified in the
normoprolactinemia group. No significant differences between acromegalic
patients with and without hyperprolactinemia were found in age at diagnosis,
gender, presence of hyperprolactinemia symptoms, insulin-like growth factor
1, growth hormone and testosterone levels, tumour volume, tumour
invasiveness, immunohistochemistry of growth hormone and prolactin, Ki-67
index and mitotic index. However, for a cut-off of 10% of
prolactin-positive cells, there was a trend towards a higher percentage of
prolactin-positive tumours in hyperprolactinemia patients (p=0.054)
and higher mean prolactin level in case of positive prolactin immunostaining
(p=0.007)). In our study there were no differences in
characteristics between acromegaly patients with hyper- and
normoprolactinemia. An association between the serum prolactin level and the
positivity of prolactin immunohistochemistry of the adenoma tissue was
found. The absence of a difference in tumour volume between patients with
hyper- and normoprolactinemia suggests that the hyperprolactinemia is likely
to be caused by the co-secretion of growth hormone and prolactin by the
tumour. Finally, for the first time, the cut-off of 10% of prolactin
cells was validated for the diagnosis of somatolactotroph tumours in
acromegaly.
Comparative Transcriptome Analysis Reveals Candidate Genes Involved in Isoquinoline Alkaloid Biosynthesis in Stephania tetrandra
Authors: Zhang Yangyang , Kang Yun , Xie Hui , Wang Yaqin , Li Yaoting , Huang Jianming 
Published: August 2020

AbstractThe roots of Stephania tetrandra are used as a traditional Chinese medicine. Isoquinoline alkaloids are considered to be the most important and effective components in this herb,
but little is known about the molecular mechanism underlying their biosynthesis. In this context, this study aimed to reveal candidate genes related to isoquinoline alkaloid
biosynthesis in S. tetrandra. Determination of tetrandrine and fangchinoline in the roots and leaves of S. tetrandra by HPLC showed that the roots had much higher contents
of the two isoquinoline alkaloids than the leaves. Thus, a comparative transcriptome analysis of the two tissues was performed to uncover candidate genes involved in isoquinoline
alkaloid biosynthesis. A total of 71 674 unigenes was obtained and 31 994 of these were assigned putative functions based on BLAST searches against 6 annotation databases. Among the 79
isoquinoline alkaloid-related unigenes, 51 were differentially expressed, with 42 and 9 genes upregulated and downregulated, respectively, when the roots were compared with the leaves.
The upregulated differentially expressed genes were consistent with isoquinoline alkaloid accumulation in roots and thus were deemed key candidate genes for isoquinoline alkaloid
biosynthesis in the roots. Moreover, the expression profiles of 10 isoquinoline alkaloid-related differentially expressed genes between roots and leaves were validated by quantitative
real-time polymerase chain reaction, which indicated that our transcriptome and gene expression profiles were reliable. This study not only provides a valuable genomic resource for
S. tetrandra but also proposes candidate genes involved in isoquinoline alkaloid biosynthesis and transcription factors related to the regulation of isoquinoline alkaloid
biosynthesis. The results lay a foundation for further studies on isoquinoline alkaloid biosynthesis in this medicinal plant.
Sigmoid Sinus Patency following Vestibular Schwannoma Resection via Retrosigmoid versus Translabyrinthine Approach
Authors: Ziegler Andrea , El-Kouri Nadeem , Dymon Zaneta , Serrano David , Bashir Mariah , Anderson Douglas , Leonetti John 
Published: August 2020

Abstract
Introduction The treatment options for acoustic neuromas are observation with serial imaging, stereotactic radiation, or surgical resection. The most common surgical approaches are the translabyrinthine (TL), the retrosigmoid (RS), and the middle cranial fossa. During the TL approach the sigmoid sinus is decompressed with bipolar cautery to allow greater medial exposure. It is unknown if this causes any long-term narrowing or thrombus of the sigmoid sinus.
Methods We performed a retrospective review of patients who underwent acoustic neuroma resection to determine if patients undergoing a TL approach for acoustic neuroma resection develop radiographic evidence of sigmoid sinus stenosis or thrombosis compared with patients undergoing a RS approach.
Results A total of 128 patients were included in this study, 56 patients underwent a TL approach and 72 patients underwent a RS approach. We compared the preoperative and postoperative diameter of the ipsilateral and contralateral sigmoid sinus at proximal, midpoint, and distal locations on magnetic resonance imaging examinations. There was no significant difference between the preoperative and postoperative diameter of the ipsilateral or contralateral sigmoid sinus based on surgical approach.
Conclusion Decompression of the sigmoid sinus during the TL approach does not have a significant postoperative effect on the dural venous sinus patency.
Pediatric Neuromuscular Disorders in Ile-Ife, Nigeria: Pattern and the Challenges with Management
Authors: Olorunmoteni Oluwatosin E. , Kareem Abiodun J. , Ayogu Musa 
Published: August 2020

AbstractThe aim of this study was to describe the presentation pattern and challenges with the management of pediatric neuromuscular disorders (NMDs) in Ile-Ife, Nigeria through retrospective review of their clinical records. We recruited 24 children aged 14 days to 15 years with a male preponderance (male-to-female ratio = 2.4:1). Late presentation was a prominent feature which was highest among children with myopathies with a mean duration of symptoms of 46.5 ± 33.4 months before presentation. Peripheral neuropathy was the most common type of NMDs (63.0%). Among these, injection nerve palsy from the use of wrong site for intramuscular injections was the most common (60.0%). Nonavailability of electrophysiologic and genetic testing as well as appropriate medications was the major challenges. Acquired NMDs are common in our setting. There is a need to improve preventive measures of acquired NMDs and early diagnosis of the inherited types.
Shortcomings in Design and Analysis of Clinical Studies on Bleeding and Thrombosis in Patients with Cirrhosis
Authors: Northup Patrick , Davis Jessica 
Published: August 2020

AbstractSignificant gains have been made in our understanding of bleeding and thrombosis in patients with liver disease in recent years, with concurrent exponential growth in the scientific literature published in this realm. Clinical studies of this population are challenging for multiple reasons including some hurdles unique to this population. Cirrhosis patients as a whole, especially those with decompensated cirrhosis, are a high-risk and heterogeneous population prone to serious adverse events. Outcomes of bleeding and thrombosis are relatively rare and lack standardized, validated definitions. Standard practices for clinical care have evolved rapidly and rendered some control data uninformative. We aim to highlight these challenges and make recommendations for best practices for future study design and implementation. Multidisciplinary collaboration with proceduralists, careful study design including attention to validated clinically relevant outcomes, and aggressive pursuit of all funding streams will be key to continued scientific success in this burgeoning field.
Incidence of Bleeding and Thrombosis in Patients with Liver Disease
Authors: Roberts Lara N. , Bernal William 
Published: August 2020

AbstractHistorically, liver disease has been associated with a bleeding tendency. Global hemostatic assays have demonstrated that hemostasis is overall rebalanced, in both acute liver failure and chronic liver disease. It is now recognized that many bleeding events in chronic liver disease are mediated by portal hypertension rather than an underlying hemostatic defect. This is acknowledged in recent guidelines, which recommend against coagulation testing prior to low risk procedures in this patient group, with avoidance also of attempts at correction of prolonged coagulation times. Over time, the incidence of bleeding events has decreased in both chronic liver disease and acute liver failure, with improved supportive care, targeted treatments for underlying cause of liver disease, and the advent of liver transplantation. Concurrently, there has been increased recognition of the risk of thrombosis in chronic liver disease, with a predilection for the splanchnic vasculature. This review describes the incidence of bleeding and thrombosis in chronic liver disease and acute liver failure, including the periprocedural and liver transplantation setting.
Three-Dimensional Finite Element Analysis to Evaluate Stress Distribution in Tooth and Implant-Supported Fixed Partial Denture–An In Vitro Study
Authors: Jain Himani , Kalra Tarun , Kumar Manjit , Bansal Ajay , Jain Deepti 
Published: August 2020

Abstract
Introduction This study was undertaken to assess the influence of different superstructure materials, when subjected to occlusal loading, on the pattern of stress distribution in tooth-supported, implant-supported, and tooth implant-supported fixed partial prostheses, using the finite element analysis with a comparative viewpoint.
Materials and Methods The geometric models of implant and mandibular bone were generated. Three models were created in accordance with the need of the study. The first model was given a tooth-supported fixed partial prosthesis. The second model was given tooth implant-supported fixed partial prosthesis, and the third model was given implant-supported fixed partial prosthesis. Forces of 100 N and 50 N were applied axially and buccolingually, respectively.
Results The present study compared the stresses arising in the natural tooth, implant, and the whole prostheses under simulated axial and buccolingual loading of three types of fixed partial dentures, namely, tooth-supported, tooth implant-supported, and implant-supported fixed partial dental prostheses using three different types of materials.
Conclusion The pattern of stress distribution did not appear to be significantly affected by the type of prosthesis materials in all models. The maximum stress concentrations were found in the alveolar bone around the neck of the teeth and implants.
COVID-19 Pandemic and the Mental Health of Health Care Workers: Awareness to Action
Authors: Rajhans Pallavi , Deb Koushik Sinha , Chadda Rakesh Kumar 
Published: August 2020

AbstractThe enormity of the coronavirus disease-2019 (COVID-19) pandemic has overwhelmed most health services and has placed health care service providers under unprecedented stress. The rapidity of spread, uncertain clinical course, and unavailability of effective treatment make clinical decisions cognitively demanding. Extended work hours inside uncomfortable protective gears, improper hydration, with conflictual health systems and patients at work; and social stigma and isolation after it ends, have created an unending downward spiral of mental health in care providers. Care providers are at increased risk of developing mental health problems in form of burnout, stress reactions, anxiety, depression, and post trauma stress. Concerted strategies for managing the mental health of care providers are urgently needed at individual and systems level. A plethora of strategies, developed from previous experience of crisis management, need to be made available to care providers through accessible mediums of delivery. This paper explores the mental health problems encountered by health care personnel and examines various strategies which need to be implemented to manage them.
The Psychological Experience of Obstetric Patients and Health Care Workers after Implementation of Universal SARS-CoV-2 Testing
Authors: Bender Whitney R. , Srinivas Sindhu , Coutifaris Paulina , Acker Alexandra , Hirshberg Adi 
Published: August 2020

Objective This study was aimed to describe the hospitalization and early postpartum psychological experience for asymptomatic obstetric patients tested for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) as part of a universal testing program and report the impact of this program on labor and delivery health care workers' job satisfaction and workplace anxiety.
Study Design This is a cohort study of asymptomatic pregnant women who underwent SARS-CoV-2 testing between April 13, 2020 and April 26, 2020. Semistructured interviews were conducted via telephone at 1 and 2 weeks posthospitalization to assess maternal mental health. Depression screening was conducted using the patient health questionnaire-2 (PHQ-2). An online survey of labor and delivery health care workers assessed job satisfaction and job-related anxiety before and during the novel coronavirus disease 2019 (COVID-19) pandemic, as well as employees' subjective experience with universal testing. Patient and employee responses were analyzed for recurring themes.
Results A total of 318 asymptomatic women underwent SARS-CoV-2 testing during this 2-week period. Six of the eight women (75%) who tested positive reported negative in-hospital experiences secondary to perceived lack of provider and partner support and neonatal separation after birth. Among the 310 women who tested negative, 34.4% of multiparous women reported increased postpartum anxiety compared with their prior deliveries due to concerns about infectious exposure in the hospital and lack of social support. Only 27.6% of women, tested negative, found their test result to be reassuring. Job satisfaction and job-related anxiety among health care workers were negatively affected. Universal testing was viewed favorably by the majority of health care workers despite concerns about delays or alterations in patient care and maternal and neonatal separation.
Conclusion Universal testing for SARS-CoV-2 in obstetric units has mixed effects on maternal mental health but is viewed favorably by labor and delivery employees. Ongoing evaluation of new testing protocols is paramount to balance staff and patient safety with quality and equality of care.
Key Points
Group singing as a resource for the development of a healthy public: a study of adult group singing
Authors: Camlin David A. , Daffern Helena , Zeserson Katherine 
Published: August 2020

AbstractA growing body of evidence points to a wide range of benefits arising from participation in group singing. Group singing requires participants to engage with each other in a simultaneous musical dialogue in a pluralistic and emergent context, creating a coherent cultural expression through the reflexive negotiation of (musical) meaning manifest in the collective power of the human voice. As such, group singing might be taken—both literally and figuratively—as a potent form of ‘healthy public’, creating an ‘ideal’ community, which participants can subsequently mobilise as a positive resource for everyday life. The experiences of a group of singers (n = 78) who had participated in an outdoor singing project were collected and analysed using a three-layer research design consisting of: distributed data generation and interpretation, considered against comparative data from other singing groups (n = 88); a focus group workshop (n = 11); an unstructured interview (n = 2). The study confirmed an expected perception of the social bonding effect of group singing, highlighting affordances for interpersonal attunement and attachment alongside a powerful individual sense of feeling ‘uplifted’. This study presents a novel perspective on group singing, highlighting the importance of participant experience as a means of understanding music as a holistic and complex adaptive system. It validates findings about group singing from previous studies—in particular the stability of the social bonding effect as a less variant characteristic in the face of environmental and other situational influences, alongside its capacity for mental health recovery. It establishes a subjective sociocultural and musical understanding of group singing, by expanding on these findings to centralise the importance of individual experience, and the consciousness of that experience as descriptive and reflective self-awareness. The ways in which participants describe and discuss their experiences of group singing and its benefits points to a complex interdependence between a number of musical, neurobiological and psychosocial mechanisms, which might be independently and objectively analysed. An emerging theory is that at least some of the potency of group singing is as a resource where people can rehearse and perform ‘healthy’ relationships, further emphasising its potential as a resource for healthy publics.