bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generalized stacked contact process with variable host fitness
Authors: Foxall Eric , Lanchier Nicolas 
Published: May 2020

AbstractThe stacked contact process is a three-state spin system that describes the co-evolution of a population of hosts together with their symbionts. In a nutshell, the hosts evolve according to a contact process while the symbionts evolve according to a contact process on the dynamic subset of the lattice occupied by the host population, indicating that the symbiont can only live within a host. This paper is concerned with a generalization of this system in which the symbionts may affect the fitness of the hosts by either decreasing (pathogen) or increasing (mutualist) their birth rate. Standard coupling arguments are first used to compare the process with other interacting particle systems and deduce the long-term behavior of the host–symbiont system in several parameter regions. The spatial model is also compared with its mean-field approximation as studied in detail by Foxall (2019). Our main result focuses on the case where unassociated hosts have a supercritical birth rate whereas hosts associated to a pathogen have a subcritical birth rate. In this case, the mean-field model predicts coexistence of the hosts and their pathogens provided the infection rate is large enough. For the spatial model, however, only the hosts survive on the one-dimensional integer lattice.
The effects of pre-sleep consumption of casein protein on next-morning measures of RMR and appetite compared between sedentary pre- and postmenopausal women
Authors: Schattinger Christopher M. , Leonard J. T. , Pappas C. L. , Ormsbee M. J. , Panton L. B. 
Published: May 2020

AbstractThe purpose of the present study was to compare next-morning responses of RMR and appetite to pre-sleep consumption of casein protein (CP) in pre- and postmenopausal women. The study was a randomised, crossover, double-blind, placebo-controlled trial. Seven sedentary premenopausal (age: 19·9 (sd 1·2) years; BMI: 23·1 (sd 2·6) kg/m2) and seven sedentary postmenopausal (age: 56·4 (sd 4·9) years; BMI: 26·3 (sd 3·5) kg/m2) women participated. During visit one, anthropometrics and body composition were measured. Following visit one, subjects consumed either CP (25 g) or placebo (PL) ≥2 h after their last meal and ≤30 min prior to sleep on the night before visits two and three. Visits two and three occurred ≥1 week after visit one and were 48 h apart. During visits two and three, RMR (VO2), RER and appetite were measured via indirect calorimetry and visual analogue scale, respectively. Anthropometrics and body composition were analysed by one-way ANOVA. RMR and measures of appetite were analysed using a 2 × 2 (menopause status × CP/PL) repeated-measures ANOVA. Significance was accepted at P ≤ 0·05. RMR was significantly lower in postmenopausal compared with premenopausal women under both conditions (P = 0·003). When consumed pre-sleep CP did not alter RMR, RER or appetite compared with PL when assessed next morning in pre- and postmenopausal women. These data contribute to growing evidence that pre-sleep consumption of protein is not harmful to next-morning metabolism or appetite. In addition, these data demonstrate that menopause may not alter next-morning RMR, RER or appetite after pre-sleep consumption of CP.
Dynamic Political Interest: How Personality Differences and the Political Environment Shape Political Interest
Authors: Larsen Erik Gahner 
Published: May 2020

AbstractIn order to explain differences in political interest, two strands of literature point to the relevance of either dispositional or situational factors. I remedy this and show how political interest is shaped by the interplay between personality differences and the political environment. Specifically, I demonstrate that people with a stable motivation for engaging with new ideas are more interested in politics when exposed to new political events, e.g. during election campaigns and when unexpected events unfold. The results have implications for our understanding of political inequalities in democratic engagement and shed light on how citizens' interest in politics can be relatively stable over time as well as responsive to the political environment in predictable ways.
Pathology associated with three newClinostomummetacercariae from Argentina with morphological and DNA barcode identification
Authors: Montes M.M. , Plaul S.E. , Croci Y. , Waldbillig M. , Ferrari W. , Topa E. , Martorelli S.R. 
Published: May 2020

AbstractIn the Laboratory of Parasites of Fishes, Crustaceans and Mollusks (CEPAVE), we undertook a parasitological study on three species of fish from the Espinal and Esteros del Iberá ecoregions of Argentina. Clinostomid metacercariae were found parasitizingCharacidium rachovii,Crenicichla vittataandGymnogeophagus balzanii. In this study, we analysed the damage that these parasites inflict on their hosts through the evaluation of histological sections. In addition,Clinostomummetacercariae were identified using morphological characters and DNA barcoding. In the pathological analysis, we observed that muscle tissue was the most affected. The inflammatory response showed vascular congestion areas and infiltration of numerous inflammatory cells, mainly lymphocytes. The molecular and morphological approach supports the presence of three new lineages of clinostomid metacercariae in Argentina. This could lead to the discovery of a high number of lineages or species ofClinostomumfrom South America.
Abortion in South Asia, 1860–1947: A medico-legal history
Authors: SHARAFI MITRA 
Published: May 2020

AbstractIn the progression of stages toward unintended lives, the two stops on either side of abortion—contraception and infanticide—have been studied extensively by historians of South Asia. We know much less about abortion, particularly during the colonial period. Drawing upon published judgments, unpublished case records, forensic toxicology reports, and treatises on Indian medical jurisprudence, this article suggests that anti-abortion law was generally enforced in colonial India only when women died as a result of illegal abortions. This approach was contrary to the Indian Penal Code (IPC), which criminalized most abortions even when the women survived. The pattern was a continuation of the pre-IPC approach in India. This article explores possible explanations for the lax enforcement of anti-abortion law in South Asia during the late nineteenth and early twentieth centuries, considering abortion as experienced by South Asian and British women alike. It proposes as contributing factors: challenges in detection, the social movement for the protection of Hindu widows, colonial anxieties about false allegations of abortion among South Asians, the common phenomenon of imperial (British) husbands and wives living apart, and physicians’ desire to protect doctor–patient confidentiality. The article focuses on two key cases involving abortion: the Whittaker-Templeton case from Hyderabad (1896–1902) in which a British woman died following an abortion; and the Parsi matrimonial case ofT. v. T.from Bombay (1927), in which a Zoroastrian woman alleged that her pharmacist husband had forced her to terminate three pregnancies by ingesting drugs.
Single-dose treatment for cutaneous leishmaniasis with an easily synthesized chalcone entrapped in polymeric microparticles
Authors: Sousa-Batista Ariane J. , Arruda-Costa Natalia , Escrivani Douglas O. , Reynaud Franceline , Steel Patrick G. , Rossi-Bergmann Bartira 
Published: May 2020

AbstractCutaneous leishmaniasis (CL) is a major health problem in many countries and its current treatment involves multiple parenteral injections with toxic drugs and requires intensive health services. Previously, the efficacy of a single subcutaneous injection with a slow-release formulation consisting of poly(lactide-co-glycolide) (PLGA) microparticles loaded with an antileishmanial 3-nitro-2-hydroxy-4,6-dimethoxychalcone (CH8) was demonstrated in mice model. In the search for more easily synthesized active chalcone derivatives, and improved microparticle loading, CH8 analogues were synthesized and tested for antileishmanial activityin vitroandin vivo. The 3-nitro-2′,4′,6′-trimethoxychalcone (NAT22) analogue was chosen for its higher selectivity against intracellular amastigotes (selectivity index = 1489, as compared with 317 for CH8) and more efficient synthesis (89% yield, as compared with 18% for CH8). NAT22 was loaded into PLGA / polyvinylpyrrolidone (PVP) polymeric blend microspheres (NAT22-PLGAk) with average diameter of 1.9μm. Although NAT22-PLGAk showed similar activity to free NAT22 in killing intracellular parasitesin vitro(IC50~ 0.2μm),in vivostudies inLeishmania amazonensis– infected mice demonstrated the significant superior efficacy of NAT22-PLGAk to reduce the parasite load. A single intralesional injection with NAT22-PLGAk was more effective than eight injections with free NAT22. Together, these results show that NAT22-PLGAk is a promising alternative for single-dose localized treatment of CL.
Cyber-victimisation and mental health in young people: a co-twin control study
Authors: Baldwin Jessie R. , Ayorech Ziada , Rijsdijk Fruhling V. , Schoeler Tabea , Pingault Jean-Baptiste 
Published: May 2020

AbstractBackgroundThe rise of social media use in young people has sparked concern about the impact of cyber-victimisation on mental health. Although cyber-victimisation is associated with mental health problems, it is not known whether such associations reflect genetic and environmental confounding.MethodsWe used the co-twin control design to test the direct association between cyber-victimisation and multiple domains of mental health in young people. Participants were 7708 twins drawn from the Twins Early Development Study, a UK-based population cohort followed from birth to age 22.ResultsMonozygotic twins exposed to greater levels of cyber-victimisation had more symptoms of internalising, externalising and psychotic disorders than their less victimised co-twins at age 22, even after accounting for face-to-face peer victimisation and prior mental health. However, effect sizes from the most stringent monozygotic co-twin control analyses were decreased by two thirds from associations at the individual level [pooled β across all mental health problems = 0.06 (95% CI 0.03–0.10) v. 0.17 (95% CI 0.15–0.19) in individual-level analyses].ConclusionsCyber-victimisation has a small direct association with multiple mental health problems in young people. However, a large part of the association between cyber-victimisation and mental health is due to pre-existing genetic and environmental vulnerabilities and co-occurring face-to-face victimisation. Therefore, preventative interventions should target cyber-victimisation in conjunction with pre-existing mental health vulnerabilities and other forms of victimisation.
RELIABILITY COMPARISON OF TWO UNIT REDUNDANCY SYSTEMS UNDER THE LOAD REQUIREMENT
Authors: Kim Kyungmee O. 
Published: May 2020

AbstractThis paper compares the reliability functions of the cold standby, hot standby, and load-sharing redundancy configurations, each of which is composed of two identical components for meeting a given system requirement. Thus far, no research has been done into the conditions that make one configuration more reliable than another because their reliability functions have no closed forms even when the component follows a Weibull lifetime distribution. In this paper, two analytical results are obtained given that the reliability of each configuration is expressed in terms of the design and operational loads of the component. First, higher reliability can be achieved in a cold standby configuration than in a load-sharing configuration if the increase in the component reliability obtained from the reduction in the operational load is not significant. Second, a cold standby configuration exhibits better reliability and carries a higher load than a hot standby configuration if the design load can be increased with a less decrease in the component reliability.
Outbreak of Salmonella Newport associated with internationally distributed raw goats' milk cheese, France, 2018
Authors: Robinson E. , Travanut M. , Fabre L. , Larréché S. , Ramelli L. , Pascal L. , Guinard A. , Vincent N. , Calba C. , Meurice L. , Le Thien MA. , Fourgere E. , Jones G. , Fournet N. , Smith-Palmer A. , Brown D. , Le Hello S. , Pardos de la Gandara M. , Weill FX. , Jourdan-Da Silva N. 
Published: May 2020

Abstract
Raw milk cheeses are commonly consumed in France and are also a common source of foodborne outbreaks (FBOs). Both an FBO surveillance system and a laboratory-based surveillance system aim to detect Salmonella outbreaks. In early August 2018, five familial FBOs due to Salmonella spp. were reported to a regional health authority. Investigation identified common exposure to a raw goats' milk cheese, from which Salmonella spp. were also isolated, leading to an international product recall. Three weeks later, on 22 August, a national increase in Salmonella Newport ST118 was detected through laboratory surveillance. Concomitantly isolates from the earlier familial clusters were confirmed as S. Newport ST118. Interviews with a selection of the laboratory-identified cases revealed exposure to the same cheese, including exposure to batches not included in the previous recall, leading to an expansion of the recall. The outbreak affected 153 cases, including six cases in Scotland. S. Newport was detected in the cheese and in the milk of one of the producer's goats. The difference in the two alerts generated by this outbreak highlight the timeliness of the FBO system and the precision of the laboratory-based surveillance system. It is also a reminder of the risks associated with raw milk cheeses.
Cerebral toxoplasmosis in HIV-infected patients over 2015–2018 (a case study of Russia)
Authors: Azovtseva O. V. , Viktorova E. A. , Bakulina E. G. , Shelomov A. S. , Trofimova T. N. 
Published: May 2020

AbstractCerebral toxoplasmosis is a leading cause of the central nervous system disorders in acquired immune deficiency syndrome. This study aimed to investigate the clinical course of cerebral toxoplasmosis in human immunodeficiency virus (HIV)-infected individuals. The study included 90 HIV-infected patients with cerebral toxoplasmosis, who underwent inpatient treatment. In case of positive enzyme immunoassay, HIV infection was confirmed with the immunoblot test. The HIV-1 ribonucleic acid level was determined using the polymerase chain reaction method. The flow cytometry was used for counting CD4 (cluster of differentiation 4 cells). Pathomorphological examination included the autopsy, gross and microscopic examination of internal organs, histological and other methods. The incidence of cerebral toxoplasmosis significantly increases at the CD4 count below 100 cells/μl,P< 0.001, and at the HIV viral load above 50 copies/ml,P< 0.05. The clinical picture of cerebral toxoplasmosis included focal symptoms, cognitive impairment, toxic syndrome, mild cerebral symptoms and a meningeal symptom. Given the absence of a specific clinical picture and the absence of abnormal laboratory and instrumental findings, the cerebral toxoplasmosis needs to be diagnosed with a number diagnostic methods combined: clinical examination, laboratory testing, immunological examination, molecular genetic testing and neuroradiological imaging.
Treatment strategies for protein-losing enteropathy in Fontan-palliated patients
Authors: Schleiger Anastasia , Ovroutski Stanislav , Peters Björn , Schubert Stephan , Photiadis Joachim , Berger Felix , Kramer Peter 
Published: May 2020

AbstractObjective:Protein-losing enteropathy is an infrequent but severe condition occurring after Fontan procedure. The multifactorial pathogenesis remains unclear and no single proposed treatment strategy has proven universally successful. Therefore, we sought to describe different treatment strategies and their effect on clinical outcome and mortality.Material and Methods:We performed a retrospective observational study. From the total cohort of 439 Fontan patients treated in our institution during the study period 1986–2019, 30 patients (6.8%) with protein-losing enteropathy were identified. Perioperative, clinical, echocardiographic, laboratory, and invasive haemodynamic findings and treatment details were analysed.Results:Median follow-up after disease onset was 13.1 years [interquartile range 10.6]. Twenty-five patients received surgical or interventional treatment for haemodynamic restrictions. Medical treatment, predominantly pulmonary vasodilator and/or systemic anti-inflammatory therapy with budesonide, was initiated in 28 patients. In 15 patients, a stable remission could be achieved by medical or surgical procedures (n = 3 each), by combined multimodal therapy (n = 8), or ultimately by cardiac transplantation (n = 1). Phrenic palsy, bradyarrhythmia, Fontan pathway stenosis, and absence of a fenestration were significantly associated with development of protein-losing enteropathy (p = 0.001–0.48). Ten patients (33.3%) died during follow-up; 5-year survival estimate was 96.1%. In unadjusted analysis, medical therapy with budesonide and pulmonary vasodilator therapy in combination was associated with improved survival.Conclusions:Protein-losing enteropathy is a serious condition limiting survival after the Fontan procedure. Comprehensive assessment and individual treatment strategies are mandatory to achieve best possible outcome. Nevertheless, relapse is frequent and long-term mortality substantial. Cardiac transplantation should be considered early as treatment option.
Exercise echocardiography demonstrates potential myocardial damage in patients with repaired tetralogy of Fallot using layer-specific strain analysis
Authors: Yazaki Kana , Takahashi Ken , Kobayashi Maki , Yamada Mariko , Iso Takeshi , Akimoto Satoshi , Shigemitsu Sachie , Matsui Kotoko , Akimoto Katsumi , Kishiro Masahiko , Nakanishi Keisuke , Kawasaki Shiori , Shimizu Toshiaki 
Published: May 2020

AbstractIntroduction:Exercise stress echocardiography and layer-specific strains are emerging as important tools for cardiac assessment. This study was aimed to evaluate layer-specific strains and torsion parameters during exercise in order to investigate the characteristics of cardiac dysfunction in patients with repaired tetralogy of Fallot and to detect subclinical left ventricular dysfunction.Materials and Methods:Thirteen patients with repaired tetralogy of Fallot (median age, 17.3 [interquartile range, 14.5–22.9] years; 6 males) and 13 controls (median age, 28.5 [interquartile range, 27.6–31.6] years; 13 males) underwent echocardiography at rest and during supine exercise. Layer-specific longitudinal strain and circumferential strain of three myocardial layers (endocardium, midmyocardium, and epicardium), torsion, and untwisting rate were measured using two-dimensional speckle-tracking echocardiography.Results:Peak endocardial papillary circumferential strain (−21.1 ± 2.6% vs. −25.8 ± 3.8%, p = 0.007), midmyocardial apical circumferential strain (−11.1 ± 4.0% vs. −15.6 ± 3.2%, p = 0.001), epicardial apical circumferential strain (−11.1 ± 4.0% vs. −15.6 ± 3.2%, p = 0.021), and torsion (8.9 ± 6.0 vs. 14.9 ± 4.8 degree, p = 0.021) were significantly lower in the repaired tetralogy of Fallot group than in the control group during exercise, though no significant difference was found between patients and controls at rest.Conclusions:Analysis of layer-specific strains and torsion parameters during exercise could detect subclinical left ventricular dysfunction in patients with repaired tetralogy of Fallot, which might reflect potential myocardial damage, at a stage where these parameters have normal values at rest. This finding provides new insight into the mechanisms of cardiac dysfunction in patients with repaired tetralogy of Fallot.
Inhibition of wheat growth planted after glyphosate application to weeds
Authors: Jang Se Ji , Mallory-Smith Carol , Kuk Yong In 
Published: May 2020

AbstractGlyphosate is easily translocated from shoots to roots and released into the rhizosphere. The objective of this study was to clarify the influence of glyphosate residues in the root tissue of glyphosate-treated weeds on wheat (Triticum aestivum L.) growth and shikimate accumulation. Foliar application to 5-leaf downy brome (Bromus tectorum L.) planted in sandy loam soil reduced wheat (‘Tubbs 06’) shoot fresh weight by 37% to 46% compared with the control when seeds were planted 0 and 1 d after applications. With Italian ryegrass [Lolium perenne L. ssp. multiflorum (Lam.) Husnot], wheat shoot fresh weight was inhibited by 20% to 34% compared with the control at 0, 1, 3, and 5 d after applications to 1.5- and 5-leaf-stage plants. Using a different wheat cultivar (‘Stephens’), shoot fresh weight was inhibited by 19% to 43% when seeds were planted 0 d after glyphosate applications to 1.5-, 2-, and 5-leaf-stage B. tectorum and L. perenne planted in sandy loam soil compared with control. In contrast, some studies using treated L. perenne and B. tectorum planted in clay loam soil resulted in increases in wheat shoot fresh weight. Lolium perenne planted in water-saturated sandy loam soil showed no differences in either shoot or root fresh weight or shikimate accumulation in shoots or roots. Compared with the control plants, shikimate accumulation in roots increased 51- to 59-fold in wheat planted in sandy loam soil that previously contained B. tectorum and 13- to 49-fold in soil that previously contained L. perenne. In both studies, glyphosate was applied at the 1.5-leaf stage, and wheat seeds were sown 0, 1, and 3 d after glyphosate applications. Thus, plant damage caused by glyphosate was associated with increased shikimate accumulation in the root tissue. Overall, crop damage caused by glyphosate residue to target plants was strongly influenced by soil type, soil water conditions, glyphosate sensitivity, target weed species identity, and weed densities.
An Improved Estimation of SuperDARN Heppner‐Maynard Boundaries Using AMPERE Data
Authors: Fogg A. R. , Lester M. , Yeoman T. K. , Burrell A. G. , Imber S. M. , Milan S. E. , Thomas E. G. , Sangha H. , Anderson B. J. 
Published: May 2020

AbstractSuper Dual Auroral Radar Network (SuperDARN) ionospheric convection maps are a powerful tool for the study of solar wind‐magnetosphere‐ionosphere interactions. SuperDARN data have high temporal (approximately minutes) and spatial (∼45 km) resolution, meaning that the convection can be mapped on fine time scales that show more detail than the large‐scale changes in the pattern. The Heppner‐Maynard boundary (HMB) defines the low‐latitude limit of the convection region, and its identification is an essential component of the standard SuperDARN convection mapping technique. However, the estimation of the latitude of this boundary is dependent on ionospheric scatter availability. Consequentially it is susceptible to nonphysical variations as areas of scatter in different latitude and local time regions appear and disappear, often due to changing propagation conditions. In this paper, the HMB is compared to an independent field‐aligned current data set from the Active Magnetosphere and Planetary Electrodynamics Response Experiment (AMPERE). A linear trend is found between the HMB and the boundary between the AMPERE Region 1 and Region 2 field‐aligned currents in the Northern Hemisphere, at both solar minimum and solar maximum. The use of this trend and the AMPERE current data set to predict the latitude position of the HMB is found to improve the interpretation of the SuperDARN measurements in convection mapping.