bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lanzamiento del Proyecto Erasmus OPT-IN y Creación de la Red de Stakeholders en Interculturalidad, Paz y Derechos de la Naturaleza en la Comunidad Andina
Authors: Estupiñan Achury Liliana 
Published: December 2019

Entre los días 8 y 11 de septiembre de 2018, y con la presencia de más de 270 asistentes (entre profesores nacionales e internaciona­les, estudiantes, líderes sociales, activistas de derechos humanos, jueces y otros miembros de la sociedad civil), se llevó a cabo el lanza­miento del proyecto ERASMUS OPT-IN y la creación de la Red de Stakeholders en inter­culturalidad, paz y derechos de la naturaleza.
El evento tuvo lugar en las instalaciones de la Universidad Libre, sede Cartagena, en el auditorio Benjamín Herrera, y su objetivo era presentar un nuevo programa de posgrado para la formación de operadores transnacio­nales e interculturales para la defensa de la naturaleza y la construcción de la paz en la Comunidad Andina.
Competitividad Empresarial en Costa Rica: un enfoque multidimensional
Authors: Alonso Suyen , Leiva Juan Carlos 
Published: December 2019

Este artículo evalúa la eficiencia competitiva de sesenta y siete pequeñas y medianas empresas costarricenses para el 2017. A partir de las bases teóricas del Enfoque Basado ​​en Recursos, se aborda metodológicamente la medición de la competitividad empresarial del grupo de empresas en estudio a través de un índice compuesto por diez pilares, según lo propuesto por Lafuente, Leiva, Moreno y Szerb (2019b). Estos pilares se encuentran interconectados y configuran la competitividad empresarial de las pymes. Para estimar su eficiencia, se realiza un modelo de análisis envolvente de datos (DEA por sus siglas en inglés), con especificación de un input y un output. Los resultados de la investigación indican que las empresas agrupadas en los sectores de manufactura y servicios muestran los índices de competitividad y eficiencia mayores, lo que es explicado por los pilares de innovación de productos y redes de negocios; mientras que los pilares menos priorizados son internacionalización, mercado interno y recursos humanos. Se concluye que el índice de competitividad es una herramienta que favorecería la toma de decisiones empresariales, pues contribuiría con en el diseño de estrategias empresariales orientadas hacia una configuración más homogénea en la asignación de recursos y capacidades.
On The Local Edge Antimagic Coloring of Corona Product of Path and Cycle
Authors: Aisyah Siti , Alfarisi Ridho , Prihandini Rafiantika M. , Kristiana Arika Indah , Christyanti Ratna Dwi 
Published: December 2019

Let be a nontrivial and connected graph of vertex set and edge set . A bijection is called a local edge antimagic labeling if for any two adjacent edges and , where for . Thus, the local edge antimagic labeling induces a proper edge coloring of G if each edge e assigned the color . The color of each an edge e = uv is assigned bywhich is defined by the sum of label both and vertices and . The local edge antimagic chromatic number, denoted by is the minimum number of colors taken over all colorings induced by local edge antimagic labeling of . In our paper, we present the local edge antimagic coloring of corona product of path and cycle, namely path corona cycle, cycle corona path, path corona path, cycle corona cycle.Keywords: Local antimagic; edge coloring; corona product; path; cycle.
Metabolism of Histone Deacetylase Proteins Opsonizes Tumor Cells to Checkpoint Inhibitory Immunotherapies
Authors: Dent Paul , Booth Laurence , Poklepovic Andrew 
Published: December 2019

Abstract
LC3-associated phagocytosis, a distinct form of autophagy, plays a key role in antigen presentation. Autophagy itself plays a central role in the regulation of cellular metabolism. Proteins that regulate autophagy include the AMPK which senses high levels of AMP, and mTOR, which integrates amino acid and fatty acid metabolism with autophagy. More recently, autophagy has been demonstrated to regulate tumor cell immunogenicity via the degradation of histone deacetylase proteins. Individual drugs and drug combinations that activate the ATM-AMPK pathway and inactivate mTOR, cause autophagosome formation. The maturation of autophagosomes into autolysosomes causes the autophagic degradation of histone deacetylase proteins who regulate the transcription of PD-L1, Class I MHCA, ODC and IDO1. Indeed, drug combinations that do not contain an HDAC inhibitor can nevertheless act as de facto HDAC inhibitors, via autophagic degradation of HDAC proteins. Such drug combinations simultaneously kill tumor cells via immunogenic autophagy and in parallel opsonize tumor cells to checkpoint inhibitor immunotherapies via reduced expression of PD-L1, ODC and IDO1, and increased expression of Class I MHCA.
Designing and Disseminating Metrics to Support Jurisdictional Efforts to End the Public Health Threat Posed by HIV Epidemics
Authors: Nash Denis 
Published: December 2019

The US Department of Health and Human Services has launched a large-scale plan that aims to “End the HIV Epidemic” (EtHE) in America, including ambitious goals and targets over the next 5 to 10 years. To be successful, the EtHE Plan will require timely dissemination of relevant metrics to inform the broad array of stakeholders who are in a position to act in support of the plan’s goals. Metrics should include both population health outcome metrics and implementation metrics that track the deployment and uptake of specific intervention delivery strategies. In addition to the usual HIV care continuum metrics that include all people living with HIV in the denominator, metrics dedicated to those not yet reached (i.e., as the denominator) are essential to help target EtHE implementation efforts. Special attention is required around metrics and targets that inform and drive action on HIV-related health disparities. Well-chosen metrics and a well-designed dissemination system can serve as important tools to assess the progress of the EtHE Plan, and to identify and disseminate lessons learned quickly within and across jurisdictions aiming to end HIV as a local public health threat.
Predicting the need for supportive services after discharged from hospital: a systematic review
Authors: Kobewka Daniel , Mulpuru Sunita , Chassé Michaël , Thavorn Kednapa , Lavallée Luke , English Shane , Neilipovitz Benjamin , Neilipovitz Jonathan , Forster Alan , McIsaac Daniel 
Published: December 2019

Abstract
Background To identify models and variables that predict the need for supportive services after discharge from acute care hospital. Methods We performed a systematic review searching the MEDLINE, CINAHL, EMBASE, and COCHRANE databases from inception to May 1st 2017. We selected studies that derived and validated a prediction model for the need for supportive services after hospital discharge for patients admitted non-electively to a medical ward. We extracted cohort characteristics, model characteristics and variables screened and included in final predictive models. Risk of bias was assessed using the Quality in Prognostic Studies tool. Results Our search identified 3362 unique references. Full text review identified 6 models. Models had good discrimination in derivation (c-statistics >0.75) and validation (c-statistics >0.70) cohorts. There was high quality evidence that age, impaired physical function, disabilities in performing activities of daily living, absence of an informal care giver and frailty predict the need for supportive services after discharge. Stroke was the only unique diagnosis with at least moderate evidence of an independent effect on the outcome. No models were externally validated, and all were at moderate or higher risk of bias. Conclusions Deficits in the ability to perform activities of daily living, and the absence of informal care givers in the home environment are the most direct determinants of the need for support services after hospital discharge. Trial Registration: This review was registered with PROSPERO #CRD42016037144
Emergency Department and Inpatient Utilization among U.S. Older Adults with Multiple Chronic Conditions: A Post-Reform Update
Authors: Ahn SangNam , Hussein Mustafa , Mahmood Asos , Smith Matthew Lee 
Published: December 2019

Abstract
Background. The Affordable Care Act (ACA) was enacted to enhance access to care primarily among nonelderly and low-income populations; however, several provisions addressed key determinants of emergency department (ED) and inpatient visits among Medicare beneficiaries over age 65 years. We take stock of the overall changes in these visits among older Medicare beneficiaries, focusing on those with multiple chronic conditions (MCCs), and provide a nationally representative post-reform update. Methods. We analyzed a sample of 32,919 older adults (65+) on Medicare from the 2006-2015 Medical Expenditure Panel Survey (MEPS). Using a survey-weighted two-part model, we examined changes in ED visits, inpatient visits, and length of stay (LOS) by MCC status, before (2006-2010), during (2011-2013), and after the ACA (2014-2015). Results. Prior to the ACA, 18.1% of Medicare older adults had ≥1 ED visit, whereas 17.1% had ≥1 inpatient visits, with an average of 5.1 nights/visit. Following ACA reforms, among those with 2+ chronic conditions, the rate of ever having an ED visit increased by 4.3 percentage points [95% confidence intervals [CI]: 2.5, 6.1, p < 0.01], whereas the rate of inpatient visits decreased by 1.4 percentage points [95%CI: -2.9, 0.2, p < 0.1], after multivariable adjustment. Conclusions. We found sizable increases in ED visits and nontrivial decreases in inpatient visits among older Medicare beneficiaries with MCCs, underscoring the continuing need for improving access to and quality of care among older adults with MCCs to decrease reliance on the ED and reduce preventable hospitalizations.
A self-administered, artificial intelligence (AI) platform for cognitive assessment in multiple sclerosis (MS)
Authors: Khaligh-Razavi Seyed-Mahdi , Sadeghi Maryam , Khanbagi Mahdiyeh , Kalafatis Chris , Nabavi Seyed Massood 
Published: December 2019

Abstract
Background
Cognitive impairment is common in patients with MS. Accurate and repeatable measures of cognition have the potential to be used as a marker of disease activity.
Methods
We developed a 5-minute computerized test to measure cognitive dysfunction in patients with MS. The proposed test –named Integrated Cognitive Assessment (ICA)– is self-administered and language-independent. 91 MS patients and 83 healthy controls (HC) took part in substudy 1, in which each participant took the ICA test and the Brief International Cognitive Assessment for MS (BICAMS). We assessed ICA’s test-retest reliability, its correlation with BICAMS, its sensitivity to discriminate patients with MS from the HC group, and its accuracy in detecting cognitive dysfunction. In substudy 2, we recruited 48 MS patients, and examined the association between the level of serum neurofilament light (NfL) in these patients and their ICA scores.

Results
ICA demonstrated excellent test-retest reliability (r=0.94), with no learning bias (i.e. no significant practice effect); and had high level of convergent validity with BICAMS. ICA was sensitive in discriminating the MS patients from the HC group, and demonstrated a high accuracy (AUC = 95%) in discriminating cognitively normal from cognitively impaired participants. Additionally, we found a strong association (r=-0.79) between ICA score and the level of NfL in MS patients.

Conclusions
ICA has the potential to be used as a digital biomarker for assessment and monitoring of cognitive performance in MS patients. In comparison to standard cognitive tools for MS (e.g. BICAMS), ICA is shorter in duration, does not show a learning bias, is independent of language, and takes advantage of artificial intelligence (AI) to identify cognitive status of patients more accurately. Being a digital test, it further has the potential for easier electronic health record or research database integration.
Does chemoradiotherapy benefit elderly patients with esophageal squamous cell cancer? A propensity-score matched analysis on multicenter data ( 3JECROG R-03A )
Authors: Chen Mingqiu , Liu Xiao hong , Han Chun , Wang Xin , Zhao Yidian , Pang Qingsong , Sun Xinchen , Li Gaofeng , Zhang Kaixian , Li Ling , Qiao Xueying , Lin Yu , Chen Junqiang , Xiao Zefen 
Published: December 2019

Abstract
Aim The aim of the present study was to assess the efficacy of concurrent chemoradiotherapy (CRT) or radiotherapy alone (RT-alone) in elderly patients with esophageal squamous cell carcinoma (ESCC). Methods The clinical data of patients with ESCC treated with RT-alone or CRT were collected and retrospectively reviewed. The 1-, 3- and 5-year overall survival (OS) rates and the clinical characteristics correlated with survival were analyzed statistically. Propensity score matching (PSM) analyses were used to compensate for differences in baseline characteristics between the CRT and RT-alone groups to confirm the survival difference. Results A total of 729 patients fulfilling the inclusion criteria were reviewed. Diabetes, primary tumor volume (pTV), primary tumor location (pTLo), clinical T stage,(cT) clinical N stage (cN), clinical M stage (cM) and short-term response to RT were independent factors influencing OS (P=0.002-0.044). The 5-year OS rate was 26.6%, 26.0% and 30.1% in the whole cohort, RT-alone and CRT groups, respectively. The survival difference between RT alone and CRT was not significant before or following PSM. Compared with the corresponding subgroups treated with RT alone, CRT significantly benefited patients with diabetes (P=0.003), cT4 (P=0.030) and cN0 (P=0.049), whereas no benefit was identified between CRT and RT alone in the other subgroups, including cT1-3, cN1, cM, pTLo, pTV, age and gender. Conclusions CRT with the current chemotherapy regimens may not improve the survival of elderly ESCC patients compared to RT-alone, except in patients with cT4 stage, cN0 stage or diabetes. However, due to the limitation of the retrospective nature of the current study, further clinical trials are required for confirmation. Key words: Concurrent chemoradiotherapy; Elderly; Esophageal squamous cell carcinoma; Survival
Comparative transcriptome profiling provides insights into plant salt tolerance in seashore paspalum (Paspalum vaginatum)
Authors: Wu Peipei , Cogill Steven , Qiu Yijian , Li Zhigang , Zhou Man , Hu Qian , Chang Zhihui , Noorai Rooksana E. , Xia Xiaoxia , Saski Christopher , Raymer Paul , Luo Hong 
Published: December 2019

Abstract
Background: Seashore paspalum (Paspalum vaginatum), a halophytic warm-seasoned perennial grass, is tolerant of many environmental stresses, especially salt stress. To investigate molecular mechanisms underlying salinity tolerance in seashore paspalum, physiological characteristics and global transcription profiles of highly (Supreme) and moderately (Parish) salinity-tolerant cultivars under normal and salt stressed conditions were analyzed. Results: Physiological characterization comparing highly (Supreme) and moderately (Parish) salinity-tolerant cultivars revealed that Supreme’s higher salinity tolerance is associated with higher Na+ and Ca2+ accumulation under normal conditions and further increase of Na+ under salt-treated conditions (400 mM NaCl), possibly by vacuolar sequestration. Moreover, K+ retention under salt treatment occurs in both cultivars, suggesting that it may be a conserved mechanism for prevention of Na+ toxicity. We sequenced the transcriptome of the two cultivars under both normal and salt-treated conditions (400 mM NaCl) using RNA-seq. De novo assembly of about 153 million high-quality reads and identification of Open Reading Frames (ORFs) uncovered a total of 82,608 non-redundant unigenes, of which 3,250 genes were identified as transcription factors (TFs). Gene Ontology (GO) annotation revealed the presence of genes involved in diverse cellular processes in seashore paspalum’s transcriptome. Differential expression analysis identified a total of 828 and 2,222 genes that are responsive to high salinity for Supreme and Parish, respectively. “Oxidation-reduction process” and “nucleic acid binding” are significantly enriched GOs among differentially expressed genes in both cultivars under salt treatment. Interestingly, compared to Parish, a number of salt stress induced transcription factors are enriched and show higher abundance in Supreme under normal conditions, possibly due to enhanced Ca2+ signaling transduction out of Na+ accumulation, which may be another contributor to Supreme’s higher salinity tolerance. Conclusion: Physiological and genomics analyses of seashore paspalum reveal major molecular underpinnings contributing to plant response to salt stress in this halophytic warm-seasoned perennial grass. The data obtained provide valuable molecular resources for functional studies and developing strategies to engineer plant salinity tolerance.
Heart Failure Management Insights from Primary Care Physicians and Allied Health Care Providers in Southwestern Ontario
Authors: Silva Narlon C Boa Sorte , Pulford Roseanne W , Lee Douglas S. , Petrella Robert J 
Published: December 2019

Abstract
Background It remains to be determined whether collaborative strategies to improve and sustain overall health in patients with heart failure (HF) are currently being adopted by health care professionals. We surveyed primary care physicians, nurses and allied health care professionals in Southwestern Ontario regarding how they currently manage HF patients and how they perceive limitations, barriers and challenges in achieving optimal management in these patients. Methods We developed an online survey based on field expertise and a review of pertinent literature in HF management. We analyzed quantitative data collected via an online questionnaire powered by Qualtrics®. The survey included 87 items, including multiple choice and free text questions. We collected participant demographic and educational background, and information relating to general clinical practice and specific to HF management. The survey was 25 minutes long and was administered in October and November of 2018 Results We included 118 health care professionals from network lists of affiliated physicians and clinics of the department of Family Medicine at Western University; 88.1% (n=104) were physicians while 11.9% (n=14) were identified as other health care professionals. Two-thirds of our respondents were females (n=72) and nearly one-third were males (n=38). The survey included mostly family physicians (n=74) and family medicine residents (n=25). Most respondents indicated co-managing their HF patients with other health care professionals, including cardiologists and internists. The vast majority of respondents reported preferring to manage their HF patients as part of a team rather than alone. As well, the majority respondents (n=47) indicated being satisfied with the way they currently manage their HF patients; however, some indicated that practice set up and communication resources, followed by experience and education relating to HF guidelines, current drug therapy and medical management were important barriers to optimal management of HF patients. Consultations Most respondents indicated HF management was satisfactory, however, a minority did identify some areas for improvement (communication systems, work more collaborative as a team, education resources and access to specialists). Future research should consider these factors in developing strategies to enhance primary care involvement in co-management of HF patients, within collaborative and multidisciplinary systems of care.
In depth analysis of the association of FTO SNP (rs9939609) with expression of the classical phenotype of PCOS: a Sri Lankan study
Authors: Branavan Umayal , Wijesundera Sulochana , Chandrasekharan Visvanath , Arambepola Carukshi , Wijeyaratne Chandrika 
Published: December 2019

Abstract
Background: PCOS is a common disorder of women due to genetic, endocrine and environmental effects that manifests from puberty. The rs9939609 variant of fat mass and obesity associated (FTO) gene is linked to metabolic derangement in PCOS. We previously identified FTO (rs9939609) as a susceptibility locus for PCOS among Sri Lankan women and also explored the role of kisspeptin. Associated factors of the FTO candidate gene among South Asians with PCOS are unknown.
Methods: This study aimed to determine the association between FTO (rs9939609) polymorphism with clinical (BMI, acanthosis nigricans, hirsutism) and biochemical (serum kisspeptin and testosterone levels) characteristics of PCOS in a cohort of Sri Lankan women. Genetic and clinical data including serum kisspeptin and testosterone concentrations of our previously reported cases (n=55) and controls (n=110) were re-analyzed, specifically for an association with rs9939609 variant of FTO gene.
Results: Logistic regression analysis (AA – OR=5.7, 95% CI=2.41-13.63, p<0.05) and genetic inheritance analysis (AA – OR=5.49, 95%CI=2.34-12.88, p<0.05) showed that FTO (rs9939609) polymorphism is significantly associated with PCOS and its metabolic manifestations. Serum testosterone was significantly higher in affected women with mutant genotypes (AA+AT) than the normal allele (TT) (p<0.05). Although serum kisspeptin was higher in subjects with PCOS and mutant alleles than controls, this difference was not significant (p>0.05).
Conclusion: FTO gene variant rs9939609 is associated with hyperandrogenemia and metabolic manifestations of PCOS among women of Sri Lankan descent with the well-characterized phenotype. Serum kisspeptin and the FTO genotypes lack a significant association when adjusted for confounders.