bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting Breast Cancer: Novel Dihydropyrimidinones As Potent Eg5 Inhibitors
Authors: Nikam Dhirajkumar , Jain Anurekha , Vetale Shraddha , Bhange Ashwini , Jadhav Shweta 
Published: December 2024

Introduction:
Breast cancer remains a formidable health concern for women, necessitating
the development of potent anticancer agents with improved safety profiles. Dihydropyrimidinones
(DHPM), pyrazole, and benzofuran scaffolds have emerged as promising targets due to their
diverse pharmacological profiles. In this study, we employed a scaffold hopping approach to design
a novel DHPM-Pyrazole-Benzofuran core. A series of compounds (3a–3j) were synthesized using
the Biginelli protocol, and their characterization was performed using various techniques such as
FTIR, 1H NMR, and Mass spectroscopy.

Methods:
Molecular docking studies against kinesin spindle protein Eg5 (1Q0B) performed to find
superior binding interactions compared to the prototype Eg5 inhibitor Monastrol. Anti breast cancer
potential of these compounds was screened against the breast adrenocarcinoma MCF-7 cell line
using an SRB assay.

Results:
Compound 3j showed good growth inhibitory activity (GI50=24.08μM) compared to Monastrol
(GI50=32μM) employed as a positive control. Moreover, Compound 3j exhibited strong
interactions with amino acids GLU-116 and ARG-119 with Eg5 protein 1Q0B.

Conclusion:
Compound 3j fits well at the allosteric site of Eg5 protein 1QOB. Compound 3j
emerged as the most cytotoxic, displaying significant and impressive growth inhibitory activity
(GI50=24.08μM).
The Structural Design and Analysis of the Multi Nozzle Relay Air-Jet Inserting System by Profile Reed Guiding for 3D Weaving Machine
Authors: Wang Yixuan 
Published: December 2024

Introduction:
Based on the literature, this article designs a parameterized simulation
model of a multi-layer jet weft insertion system by profiles reed guidance for a 3D loom on the
PTC Creo9.0 platform, including the main supersonic nozzle, supersonic auxiliary nozzle (relay
nozzle), and multi-slot profiles reed components.

Method:
Based on the existing basic theory, experimental results, and empirical data of turbulent
jet, the parameters of the multi-layer jet weft insertion system, as well as the structural parameters
and the relative positions of the main, auxiliary nozzle and profile reed components, such as the
center distance of each layer's main nozzle, auxiliary nozzle spacing, auxiliary nozzle installation
angle, spray direction angle, and spray angle, have been determined preliminarily.

Result:
Further, the basic flow field parameters, such as the supply pressure of the main and auxiliary
nozzles and the shape of multi-layer profile reeds, have been determined optimally on the Virtual
Prototype Collaborative Simulation Platform (PTC Creo9.0/ANSYS Workbench/Fluent
2024R1), and the rationality of the structural design also been verified; on the premise of ensuring
that the airflow velocity of each layer's profiles groove meets the requirements of weft insertion,
the design and simulation calculation is repeatedly modified, and the optimal structural design parameters
of the multi-layer weft insertion system and nozzle is finally determined.

Conclusion:
To explore the feasibility of multi-layer jet weft insertion, the design of threedimensional
multi-layer jet weft insertion looms has laid a theoretical foundation, laying a good
foundation for the emergence and industrial manufacturing of three-dimensional multi-layer jet
weft insertion looms, and providing an important reference for the innovative design of threedimensional
multi-layer water jet weft insertion looms.
Investigating the Influence of 0.75% Ethanol Extract Gel from “Kaempferia galanga L Rhizoma” on Mild and Moderate Acne Vulgaris Among High School Students
Authors: Bahar Yenni , Sentono Harijono Kario , Doewes Muchsin , Soetrisno  
Published: December 2024

Background:
Acne vulgaris is a prevalent dermatological condition characterized by
the inflammation of sebaceous follicles. This inflammation results in various clinical manifestations,
including open and closed comedones, papules, pustules, nodules, and cysts, which predominantly
appear on the face. The impact of acne vulgaris extends beyond physical symptoms, often
affecting psychological well-being and quality of life, particularly among adolescents. Given this
condition's widespread prevalence and significant implications, there is a pressing need for effective
and accessible treatments.

Objective:
This study aimed to evaluate the impact of Kencur Rhizome Ethanol Extract Gel
(Kaempferia galanga L. Rhizoma / KGR) on mild and moderate acne vulgaris lesions among high
school students.

Method:
Twenty-four high school students were divided into three groups: Group 1 received
0.75% Kaempferia galanga rhizome ethanol extract gel, Group 2 received a combination gel of
0.75% Kaempferia galanga ethanol extract, and 75% benzoyl peroxide with 1% clindamycin gel,
and Group 3 received 1% clindamycin gel. The number of subjects in each group was determined
using the G Power application. The distribution of gels was randomly assigned using the “Randomly
Assign Subjects to Treatment Group” application. Before treatment, blood samples were
taken to measure IL-8 levels. After three weeks of treatment, bilateral facial photographs were taken:
one with the right side tilted at 45 degrees and the other with the left side tilted at 45 degrees.
Blood samples were collected again for IL-8 measurement, and high-resolution photographs of
both sides of the face were taken to analyze acne lesions using the ImageJ application.

Result:
A combination of 0.75% KGR ethanol extract gel and 1% clindamycin gel significantly reduced
the severity of AV lesions by affecting IL8 expression (p=0.042) in reducing the severity of
mild and moderate AV lesions. For AV lesions using the ImageJ application, the administration of
group 2 gel (a combination of 0.75% KGR ethanol extract gel and 1% clindamycin gel) has a significant
effect on reducing the severity of mild and moderate degrees of whitehead or blackhead
(p = 0.030) and nodules (p = 0.035) in acne vulgaris.

Conclusion:
A combination of 0.75% kencur rhizome ethanol extract gel and 1% clindamycin gel
effectively alleviate acne vulgaris symptoms while also reducing inflammation of acne vulgaris lesions.
The Impact of the Coronavirus Pandemic on Telemedicine Evolution in Obstetrical Care During COVID-19
Authors: Nori Wassan , Fadhil Amenah , Jaafar Zainab Abdul Ameer 
Published: December 2024

Abstract:
The COVID-19 pandemic has imposed drastic challenges to the health system and resulted
in drastic measures to reduce the high morbidity and mortality rates observed among affected
individuals. Pregnant women were faced with an unexpected suspension of anti-natal care with the
recommendation of indoor confinement. Telemedicine (Tm), defined as the delivery of healthcare
via communication, stood up as a valuable tool to address those needs with its convenience of remote
monitoring and ease of use. This review aimed to verify the transition of Tm in obstetrical care, define
factors and barriers associated with its acceptance, its performance, and how it evolved during
the COVID-19 era to guide its role in modern obstetrics. Four electronic repositories were searched:
PubMed, Scopus, WOS, and Google Scholar using the keywords (pregnant, telemedicine, COVID-
19, feto-maternal health, outcome, satisfaction, and health care); eligible studies were included in the
analysis. Despite the challenges and difficulties faced by Tm during its early implementation in the
pandemic, its effectiveness was demonstrated. Looking back to the lessons learned from the pandemic,
Tm stood out as a reliable, safe, cost-effective tool for delivering anti-natal care during lockdown.
Its role in alleviating anxiety and stress associated with the pandemic was notable. There are still
gaps in our knowledge that need to be researched further, practically, the long-term outcome of Tm
follow-up for both the mothers and their babies, and from a lower income countries' perspective as
Tm services faced digital literacy in those areas. It has been anticipated that Tm will play a crucial
role in modern obstetrics, as an integral part of the health service or as a complete part. Moreover, by
adopting the 2 models, pregnant women will have the leverage of to aim for better delivery and outcomes
in the presented health care.
Influence of the Gut Microbiota, Metabolism and Environment on Neuropsychiatric Disorders
Authors: Wang Mengxia , Ma Yan , Zeng Bao , Yang Wenhao , Huang Cuihong , Tang Benqin 
Published: December 2024

Abstract:
The two-way communication between intestinal microbiota and the central nervous system
(the microbiota-gut-brain axis) is involved in the regulation of brain function, neurodevelopment,
and aging. The microbiota-gut-brain axis dysfunction may be a predisposition factor for
Parkinson’s disease (PD), Alzheimer’s disease (AD), Autism spectrum disorder (ASD), and other
neurological diseases. However, it is not clear whether gut microbiota dysfunction contributes to
neuropsychiatric disorders. Changes in the gut microbiota may modulate or modify the effects of
environmental factors on neuropsychiatric disorders. Factors that impact neuropsychiatric disorders
also influence the gut microbiota, including diet patterns, exercise, stress and functional gastrointestinal
disorders. These factors change microbiome composition and function, along with the
metabolism and immune responses that cause neuropsychiatric disorders. In this review, we summarized
epidemiological and laboratory evidence for the influence of the gut microbiota,
metabolism and environmental factors on neuropsychiatric disorders incidence and outcomes. Furthermore,
the role of gut microbiota in the two-way interaction between the gut and the brain was
also reviewed, including the vagus nerve, microbial metabolism, and immuno-inflammatory responses.
We also considered the therapeutic strategies that target gut microbiota in the treatment
of neuropsychiatric disorders, including prebiotics, probiotics, Fecal microbiota transplant (FMT),
and antibiotics. Based on these data, possible strategies for microbiota-targeted intervention could
improve people’s lives and prevent neuropsychiatric disorders in the future.
Cognitive peering infrastructure for the organization teamwork on projects based on agile methodology
Authors: Karamysheva N. S. , Aleksandrov V. S. , Kiryutkin I. A. , Zinkin S. A. 
Published: December 2024

Purpose of research. The goal of the work is to develop and justify a cognitive peer-to-peer infrastructure that will improve the conditions for collective work on projects based on agile methodology. Cognitive architecture is defined as a structure that ensures the implementation of anthropomorphic and neuromorphic functions in natural or artificial systems. The proposed approach is based on organizing the interaction of the collective intelligence of members of an agile team and artificial intelligence, represented by trained artificial neural networks. When forming an agile team, it is proposed to take into account the structure of the cognitive sphere in the structure of the mental processes of a human cognitive agent.Methods. Domain knowledge is determined based on the collective intelligence of the agile team members and the training of artificial neural networks. It is assumed that artificial neural networks are available to all members of an agile team and implement the functions of collective artificial intelligence, provided that their training uses the professionalism and experience of a person in a natural social environment. Mental operations such as analysis, partitioning (modularization), comparison, abstraction, synthesis, generalization, classification, concretization, known from general psychology courses, are interpreted not only as a result of human activity, but also as the functionality of a program. Some elements of the cognitive sphere processes “memory” and “speech” are realized in a similar way.Results. The system is implemented on the basis of a peer-to-peer computer network that provides communications between all artificial and natural participants in the cognitive process during the design process. A conceptual model of a cognitive collective intelligence cell is proposed, combining elements of the actual collective intelligence of agile agents with the collective artificial intelligence of agents based on neural networks. In an expert assessment of the quality of individual design stages, it was proposed to use tagging based on the emotional-volitional and motivational mental processes of individuals.Conclusion. Cognitive information processing is based on the idea of modeling human thinking processes in computer systems. In the system under consideration, this includes natural language processing, written speech recognition, associated with understanding information through software imitation of human intelligence. The accepted concept involves the implementation of collective intelligence not only artificially, but also by organizing convenient interaction between participants in an intellectual chat. Artificial intelligence, also collective, is implemented using initially trained and further trained neural networks.
Development of a method for localizing objects in a closed and saturated environment
Authors: Mostakov N. A. , Zakharova A. A. 
Published: December 2024

The purpose of the work is to study and develop methods for localizing an ultra-light unmanned aerial vehicle (UAV) in a closed environment saturated with objects, based on semantic and topological data obtained from the environment. The purpose of the work is also to develop software and select a hardware complex for launching and testing the developed solution.Methods. To achieve this goal, a review and comparison of existing solutions were conducted. Optimization of the neural network architecture for detecting objects. Development of an algorithm for compiling a graph of objects reflecting their relationships. Development of an algorithm for comparing graphs to determine the position of the UAV. Implementation of a solution to improve the accuracy of determining the geometric center of detected objects. Use of keypoint detection methods (SIFT, SURF) to solve the problem of identifying objects of the same class.Results. The result of the work is a developed localization method based on semantic and topological data obtained from the environment. A software package based on the ROS2 humble platform and implemented on the hardware based on the Rockchip 3588 board was also developed. The experiments were conducted on ready-made datasets (KUM dataset) and using UAVs indoors.Conclusion. The developed localization system is a promising step towards creating efficient and flexible systems capable of operating in complex conditions. In the future, it is planned to integrate this method with other sensors to improve robustness in dynamic conditions, add visual odometry algorithms to improve the accuracy of UAV localization, and expand the application of the system to UAVs used in other industries (infrastructure inspection, search and rescue).
Measuring-polynomial processing of input data of a computer system
Authors: Loktionov A. P. , Vatutin E. I. 
Published: December 2024

Purpose of research. The purpose of this study is to solve the problem of restoring the external load on the rack– and-beam structural system and to assess the impact on the accuracy of solving the problem of the error of noisy deflections – constructive input data of the computing system.Methods. The main scientific methods used in this study are methods of modeling and identification of boundary conditions, the grid method of regularization of solving inverse incorrect problems. Measurement reduction and approximation methods, methods for evaluating the quality of input data processing, regularization and approximation algorithms using the Lebesgue grid function, and numerical methods are also used.Results. The main result of this work is two theorems about the external load on a rack-and-beam structural system. The existence and uniqueness of the solution is proved. Also, the results are the formulas of Lagrange multipliers in linear Lagrangian approximation and the optimal plan of coordinates of the nodes of the approximation grid for the equation of deflections of the beam of the fourth and fifth degree with Chebyshev alternance. An assessment of the quality of the approximation of the external load on the rack-and-beam structure by the values of the target parameters was carried out.Conclusion. This article proposes a method for restoring the external load on a rack-and-beam structure using the results of solving the inverse Cauchy problem for the equation of deflections of a beam with minimizing the influence of the error of noisy input data.
Participant Adherence and Contact Behavior in a Guided Internet Intervention for Depressive Symptoms: Exploratory Study
Authors: Bur Oliver Thomas , Berger Thomas 
Published: December 2024

Abstract

Background
The number of studies on internet-based guided self-help has rapidly increased during the last 2 decades. Guided self-help comprises 2 components: a self-help program that patients work through and usually weekly guidance from therapists who support patients using the self-management program. Little is known about participants' behavior patterns while interacting with therapists and their use of self-help programs in relation to intervention outcomes.

Objective
This exploratory study aimed to investigate whether the number of messages sent to the therapist (ie, contact behavior) is an indicator of the outcome, that is, a reduction in depressive symptoms. Furthermore, we investigated whether adherence was associated with outcome. Most importantly, we investigated whether different combinations of adherence and contact behavior were associated with outcome.

Methods
Drawing on a completer sample (n=113) from a randomized full factorial trial, participants were categorized into 4 groups. The groups were based on median splits of 2 variables, that is, the number of messages sent to therapists (low: groups 1 and 2; high: groups 3 and 4) and adherence (low: groups 1 and 3; high: groups 2 and 4). The 4 groups were compared in terms of change in depressive symptoms (measured with the Patient Health Questionnaire-9) from pre- to posttreatment and pretreatment to follow-up, respectively.

Results
On average, participants sent 4.5 (SD 3.7) messages to their therapist and completed 18.2 (SD 5.2) pages of the program in 6.39 (SD 5.39) hours. Overall, analyses revealed no main effect for participants’ messages (H1=0.18, P=.67) but a significant main effect for adherence on changes in depressive symptoms from pre- to posttreatment (H1=5.10, P=.02). The combined consideration of adherence and messages sent to the therapist revealed group differences from pre- to posttreatment (H3=8.26, P=.04). Group 3 showed a significantly smaller improvement in symptoms compared with group 4 (Z=–2.84, P=.002). Furthermore, there were group differences from pretreatment to follow-up (H3=8.90, P=.03). Again, group 3 showed a significantly smaller improvement in symptoms compared with group 4 (Z=–2.62, P=.004) and group 2 (Z=–2.47, P=.007). All other group comparisons did not yield significant differences.

Conclusion
This exploratory study suggests that participants characterized by low adherence and frequent messaging do not improve their symptoms as much as other participants. These participants might require more personalized support beyond the scope of guided internet interventions. The paper underscores the importance of considering individual differences in contact behavior when tailoring interventions. The results should be interpreted with caution and further investigated in future studies.
Teenager Substance Use on Reddit: Mixed Methods Computational Analysis of Frames and Emotions
Authors: Zhang Xinyu , Zhu Jianfeng , Kenne Deric R , Jin Ruoming 
Published: December 2024

Background
Adolescent substance use disorder is a pressing public health issue, with increasing prevalence as individuals age. Social media platforms like Reddit (Reddit Inc) serve as significant venues for teenagers to discuss and navigate substance use. Social media platforms, such as Reddit, serve as increasingly important spaces where teenagers discuss, share, and navigate their experiences with substance use, presenting unique opportunities and challenges for understanding and addressing this issue.

Objective
This study aims to explore how teenagers frame substance-use discussions on the r/teenagers subreddit, focusing on their personal interpretations, causal attributions, and the social and psychological contexts that shape these online support groups. By identifying these interpretive frames, we aimed to better understand the complex drivers of adolescent substance use behavior and their potential interventions.

Methods
Using natural language processing techniques, we analyzed 32,674 substance use–related posts from 2018 to 2022. A framing approach was used to identify and categorize prevalent themes, supplemented by emotional profiling using the EmoLLaMA-chat-13B model developed by Liu and colleagues.

Results
In total, 7 primary frames emerged: normalization, risk awareness, social integration, autonomy and rebellion, coping mechanisms, media influence, and stigmatization. These frames varied in prevalence and were associated with distinct emotional profiles, highlighting the complex interplay between substance use and adolescent experiences. We observed that, for example, the normalization frame was often associated with a mix of sadness and anxiety, while the coping frame exhibited elevated levels of anger, sadness, and anxiety. These distinctive emotional landscapes associated with each frame reveal unique insights into the mental state of adolescents navigating substance use.

Conclusions
The findings underscore the multifaceted nature of adolescent substance-use discussions on social media. Interventions must address underlying emotional and social factors as well as identity to effectively mitigate substance use disorder among adolescents. By understanding the frames teenagers use to interpret substance use, we can pave the way for more effective and personalized public health campaigns, and support services designed to resonate with adolescents’ unique lived experiences.
Higher-Order Moment Risk and ESG Sentiment: Evidence from China’s Options Market
Authors: Yu Haixu , Liu Zhaohua 
Published: December 2024

The relationship between risk and return is an important topic in financial research. In this paper, we investigate the factors affecting the higher-order moment risk premiums. The results indicate that there is a significant interaction between variance, skewness and kurtosis when considering risk premiums. This implies that there are both common and independent sources of risk information. In addition, ESG news sentiment has a significant positive effect on volatility risk premium.