bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multifocal cholesterol granulomas of the anterior mediastinum
Authors: Manabe Takehiko , Oka Soichi , Ono Kenji 
Published: July 2020

Abstract
Background
Cholesterol granuloma in the mediastinum is rarely observed, accounting for 1% of all mediastinum tumors. There have been only a few reports of multifocal cholesterol granulomas of the thymus. We herein report a rare case of multifocal cholesterol granuloma in the thymus that was incidentally detected during follow-up of an aortic aneurysm.

Case presentation
The patient was a 70-year-old man with dyslipidemia and hypertension who was referred to our hospital to undergo an operation for chest aortic aneurysm. Preoperative computed tomography (CT) showed 4 lesions in the anterior mediastinum measuring up to 4 cm in size with slight contrast enhancement and spotty calcification. Therefore, a thymoma, bronchogenic cyst, or lymphangioma were considered as the preoperative diagnosis. The patient underwent total thymectomy under thoracotomy followed by aortic arch replacement for the aortic aneurysm. The pathological diagnosis was multifocal cholesterol granulomas in the thymus.

Conclusions
Cholesterol granulomas should be included in the differential diagnosis of cystic tumor in the mediastinum, especially in patients with basal disease such as dyslipidemia and hypertension, which may lead to aortic aneurysm. Furthermore, complete surgical resection and a detailed histological evaluation are important for the accurate diagnosis and treatment.
Comparison of the fluorescence microscopy Cyscope® with light microscopy for malaria diagnosis in a small and active surveillance in Cameroon
Authors: Mbohou Nchetnkou Christian , Nyabeyeu Nyabeyeu Hervé , Kojom Foko Loick P. , Lehman Leopold G. 
Published: July 2020

Abstract
Background
Malaria has a negative impact on the activities of companies in endemic countries especially in Cameroon. In this regard, an increasingly growing number of companies have started to include management of malarious patients in their health policies. In the present study, we will evaluate the diagnostic performances of a fluorescence microscopy (FM), Cyscope® microscope, in the detection of malaria parasites.

Methods
A cross-sectional study was conducted among employees of two companies of the town of Douala on 21 and 22 March 2017. Sociodemographic information of employees was collected using a questionnaire form. Blood samples of ~ 10 μL were collected by venipuncture for the diagnosis of malaria using FM and light microscopy (LM). Performances of FM with respect to sensitivity (Se), specificity (Sp), positive and negative predictive values (PPV and NPV), positive and negative likelihood rates (PLR and NLR), accuracy, reliability, and Kappa index were calculated using LM as gold standard.

Results
In total, 442 employees, aged 37.8 ± 9.7 years old on average, were included in the study. Prevalence of malaria using FM and LM was 39.2% and 17%, respectively (p < 0.01). Plasmodium falciparum and P. vivax were the two species involved in malaria infection cases. In terms of developmental stages, 68%, 45.3%, and 1.3% of employees carried gametocytes, trophozoites, and schizonts, respectively. Findings on diagnostic performances of FM were as follows: Se = 84%, Sp = 69.95%, PPV = 63.58%, NPV = 95.5%, accuracy = 89.36%, and reliability = 53.95%. Sensitivity of Cyscope® microscope increased as a function of parasitemia with values ranging from 76.92% at parasitemia between 1 and 500 parasites/μL to 91.11% at parasitemia between 501 and 5000 parasites/μL. The geometric mean parasite density was1850 parasites per μL of blood (range 1600–40,000), and most of employees (60.8%) had moderate parasitemia. The performances of FM were similar between febrile and afebrile patients.

Conclusions
This study showed good performances of Cyscope® microscope and outlines that this diagnostic tool could be used in management of malaria at workplace.
Fibrosing pneumonia – how to diagnose, and how to recognize the etiology?
Authors: Popper Helmut H.- 
Published: July 2020

Abstract
Background
Fibrosing pneumonias are a group of interstitial lung diseases with a different etiologic background and divergent prognosis. They are differentiated into usual interstitial pneumonia (UIP), non-specific interstitial pneumonia (NSIP), and organizing pneumonia (OP). Some of these entities were initially described by A. Liebow.

Main
In the 90ties the main differences in survival lead to the separation of UIP/IPF as a disease with dismal outcome, from the prognostically better NSIP and OP. Later it was shown that fibrosing NSIP confers an almost identical worse prognosis. Under the heading of pulmologists a classification was created, where the diagnosis has to be established by a multidisciplinary team, based on pattern recognition done by radiologists and pathologists. A clinical diagnosis has to be established based on the patterns: UIP pattern was the basis for IPF, NSIP pattern for the clinical diagnosis NSIP, and organizing pneumonia pattern for the diagnosis of cryptogenic organizing pneumonia. This created confusion, because the pattern UIP was taken almost as synonymous with idiopathic pulmonary fibrosis (IPF). Later on in many articles and classifications the role of the pathologic diagnosis was diminished, because pulmologists based their diagnosis on CT-scan and clinical presentation. This resulted in less tissue biopsies but also delay and misinterpretation of diseases. Even new techniques in tissue biopsies such as cryobiopsy was regarded as unnecessary.

Conclusion
Tissue analysis in fibrosing pneumonias is still the gold standard in making a diagnosis and also evaluating the etiologic background. After an analysis the findings should be discussed in a multidisciplinary board to establish a final diagnosis and a treatment option for the patient.
Comparative study between magnesium sulphate and dexmedetomidine in controlled hypotension during functional endoscopic sinus surgery: a prospective randomized study
Authors: Bayoumy Aya A. , Abo Zeid Gihan S. , El Deek Abeer M. , Elbeialy Marwa A. 
Published: July 2020

Abstract
Background
Functional endoscopic sinus surgery (FESS) has been proposed as a selected treatment used in patients with chronic sinusitis that have not responded to medical therapy. Due to the nature of the location of endoscopic sinus surgery, even a small amount of bleeding can reduce the operative visibility. The aim of the work was to compare between dexmedetomidine and magnesium sulphate regarding their efficacy as a hypotensive agent in FESS in adult patients to obtain a bloodless surgical field.

Patients and methods
Sixty patients were randomly assigned into two groups, (D group) for dexmedetomidine (n = 30) and (M group) for magnesium sulphate (n = 30). In (D group), patients received 1 μg/kg dexmedetomidine in 100 ml saline solution as the loading dose 10 min before induction and 0.5–1 μg/kg/h infusion via syringe pump during surgery. In (M group), patients received 40 mg/kg magnesium sulphate in 100 ml saline solution over 10 min as the intravenous loading dose 10 min before induction, with a subsequent 10–15 mg/kg/h infusion. If there is an increase in the arterial blood pressure greater than the targeted MAP (55–65 mmHg), nitroglycerine infusion was started by 0.5 μg/kg/min. The surgeon estimated the quality of the surgical field and recorded it. The total blood loss was measured. In recovery, time to reach Aldrete score ≥ 9 was recorded to fulfill the discharge criteria. Pain score was assessed by the NRS numerical rating score. The time needed to first analgesia requirement was recorded. Sedation score was recorded using Ramsay sedation score.

Results
There was no statistically significant difference between both groups regarding MAP except at 30 min postoperatively as there was a statistically significant decrease in the MAP among the dexmedetomidine (D group) (p = 0.039). Nitroglycerine was required in eight cases in the magnesium sulphate (M group) to reach the targeted MAP which was statistically significant compared to the (D group). Patients in the (D group) had a statistically significant decrease in heart rate than in the (M group) during and after the operation (p = 0.35). The quality of the surgical field was significantly better among the (D group) (p < 0.05), and accordingly, the surgeon satisfaction was significantly higher in the (D group) (p = 0.001). Time to reach Aldrete score ≥ 9 and time for first analgesic requirement postoperatively were significantly longer in the (D group) (p = 0.023, p = 0.001 respectively). Regarding the Ramsay sedation score (RSS), it was higher in the (D group) which was statistically significant (p ≤ 0.001).

Conclusion
Dexmedetomidine was more effective than magnesium sulphate to achieve controlled hypotension in patients undergoing FESS. Compared with magnesium, dexmedetomidine offers the advantage of better clarity of the field, surgical satisfaction, less bleeding, and prolonged postoperative analgesia.
Stress, nutrients and genotype: understanding and managing asparagine accumulation in wheat grain
Authors: Oddy Joseph , Raffan Sarah , Wilkinson Mark D. , Elmore J. Stephen , Halford Nigel G. 
Published: July 2020

Abstract
Plant stress and poor crop management strategies compromise the foundations of food security: crop yield, nutritional quality and food safety. Accumulation of high concentrations of the amino acid asparagine in its free (soluble, non-protein) form is an example of an undesirable outcome of stress for the nutritional quality and food safety of wheat because of its role as a precursor to acrylamide, a carcinogenic processing contaminant. In this review, we cover what is known about the mechanisms and functions of free asparagine accumulation in the grain during normal development and particularly during stress in wheat. Comparisons with other plant species, yeast, and mammals are drawn in order to gain deeper insight into the conserved biology underlying asparagine accumulation. Crop management strategies and practices are discussed in the context of managing asparagine accumulation, which must be balanced against other desirable goals, such as sustainability, protein content and yield.
Evaluating the Effect of Medicaid Expansion on Black/White Breast Cancer Mortality Disparities: A Difference-in-Difference Analysis
Authors: Semprini Jason , Olopade Olufunmilayo 
Published: July 2020

PURPOSE Medicaid expansion was designed to increase access to health care. Evidence is mixed, but theory and empirical data suggest that lower cost of care through greater access to insurance increases health care utilization and possibly improves the health of poor and sick populations. However, this major health policy has yet to be thoroughly investigated for its effect on health disparities. The current study is motivated by one of today’s most stark inequalities: the disparity in breast cancer mortality rates between Black and White women. METHODS This analysis used a difference-in-difference fixed effects regression model to evaluate the impact of Medicaid expansion on the disparity between Black and White breast cancer mortality rates. State-level breast cancer mortality data were obtained from the Centers for Disease Control and Prevention. Each state’s Medicaid expansion status was provided by a Kaiser Family Foundation white paper. Two tests were conducted, one compared all expanding states with all nonexpanding states, and the second compared all expanding states with nonexpanding states that voted to expand—but did not by 2014. The difference-in-difference regression models considered the year 2014 a washout period and compared 2012 and 2013 (pretreatment) with 2015 and 2016 (posttreatment). RESULTS Medicaid expansion did not lower the disparity in breast cancer mortality. In contrast to expectations, the Black/White mortality ratio increased in states expanding Medicaid for all Medicaid-eligible age groups, with significant effects in younger age groups ( P = .01 to .15). CONCLUSION These results suggest that states cannot solely rely on access to insurance to alleviate disparities in cancer or other chronic conditions. More exploration of the impacts of low-quality health systems is warranted.
Gender, Radicalization, and the October Days
Authors: Desan Suzanne 
Published: July 2020

AbstractIn 1789 the forms and legitimacy of revolutionary crowd activism emerged out of Old Regime practices, but the pivotal role of gender dynamics in this radicalizing process has not yet been fully understood. This article rethinks the October Days by examining the occupation of the National Assembly and making three central claims. First, female marchers fused revolutionary political knowledge with older forms of bodily and spatial politics. Second, women's and men's practices operated in tandem. The growing presence of armed, working men deepened the journée's impact on deputies and king. Third, gendered behavior and expectations enabled Parisians to forge revolutionary claims within Old Regime frameworks, including rioting for subsistence and building on and beyond carnivalesque acts of inversion. In essence, the gender dynamics and political context of the event allowed a largely female crowd to smuggle the expansion of popular sovereignty in through the back door.En 1789, les formes et la légitimité de la foule révolutionnaire ont émergé de pratiques issues de l'Ancien Régime. Cependant, notre connaissance du rôle clé joué par la dynamique du genre au sein de ce processus de radicalisation demeure lacunaire. Afin de repenser les journées d'octobre, cet essai examine l'occupation de l'Assemblée nationale et propose trois arguments cruciaux. En premier lieu, les manifestants ont fusionné leur connaissance de la politique révolutionnaire avec des formes plus anciennes de la politique du corps et de l'espace. Deuxièmement, les femmes et les hommes ont mené des pratiques politiques en tandem. La présence croissante d'hommes armés, souvent employés comme ouvriers, a intensifié l'impact de cette journée sur les députés et sur le Roi. Plus généralement, les Parisiennes et les Parisiens ont pu établir, à travers leurs attentes et leurs comportements genrés, des revendications révolutionnaires dans le cadre de coutumes d'Ancien Régime, notamment par le biais d'émeutes de subsistance et d'inversion carnavalesque. En fait, grâce aux dynamiques liées au genre et au contexte politique, une foule majoritairement féminine a introduit l'expansion de la souveraineté populaire par la petite porte.
France Speaks!
Authors: Palacios Cerezales Diego 
Published: July 2020

AbstractIn 1851 more than 1.6 million signatures endorsed a petition for an amendment to the 1848 constitution that would have allowed Louis-Napoléon Bonaparte to stand for reelection. Following contemporary critics who claimed that the movement had been orchestrated by the government, scholars have been little impressed by this mobilization, which produced the largest petition of nineteenth-century France. By analyzing the petitions and the signatures themselves, official reports, correspondence of key actors, and the public debate, this article reappraises the campaign, making three claims: that a government-sponsored petition merits analysis in the context of the explosion of popular mobilization that followed 1848, that the depiction provided by the republicans of the participation of the administration in the campaign is partial and incomplete, and that the petitioners were not dependent and manipulated individuals but purposeful citizens who understood and supported the petition they signed. The article concludes that the campaign would not have succeeded without the genuine popularity of the president and the surfacing of a strong popular Bonapartist undercurrent.En 1851, des pétitions, rassemblant plus de 1,6 million de signatures, ont demandé une révision de la Constitution permettant à Louis-Napoléon Bonaparte de se porter candidat à un deuxième mandat présidentiel. Selon les républicains, le mouvement avait été orchestré et manipulé par le gouvernement, et les historiens ont aussi dédaigné cette mobilisation, alors qu'elle était la pétition la plus signée en France au dix-neuvième siècle. En analysant les pétitions et les signatures elles-mêmes, les rapports officiels, la correspondance des acteurs clés et le débat public, l'article réévalue cette campagne et propose trois arguments : (1) que les pétitions parrainées par le gouvernement font partie de l'histoire des mobilisations populaires ; (2) que l'image d'une administration toute-puissante mise au service de la campagne ne correspond pas à la réalité ; et enfin (3) que la plupart des pétitionnaires n'étaient pas des individus manipulés, mais des citoyens conscients du sens de leurs actions. La campagne n'aurait pas réussi sans l'expérience de la démocratie depuis 1848, la popularité du président et l'émergence d'un bonapartisme populaire.
“This Is No Longer a Book, It Is a Political Event”
Authors: Sampaio Guilherme 
Published: July 2020

AbstractSince its publication in 1919, John Maynard Keynes's Economic Consequences of the Peace has left a deep imprint on interpretations of the Treaty of Versailles and subsequent reparations discussions. Current scholarship on the treaty has accurately reassessed Keynes's conclusion that French peace aims were purely vindictive, but it has erroneously claimed that Consequences was a biased book barely read in France. By placing the reception of Consequences in the context of domestic French debates on the Versailles peace in 1920, this article demonstrates instead that Keynes's book was substantially discussed in France and that it garnered supporters among academic economists and on the left. Furthermore, examining the French networks that helped Keynes publish a translation of his book in the prestigious Nouvelle revue française problematizes his alleged Germanophilia.Dès sa publication en 1919, Les conséquences économiques de la paix de John Maynard Keynes a profondément influencé les analyses faites par les contemporains et les historiens sur le Traité de Versailles et la question des réparations allemandes. Aujourd'hui, l'historiographie concernant ces questions a beaucoup nuancé l'argument de Keynes selon lequel le traité avait imposé une « paix carthaginoise » à l'Allemagne. Mais elle a aussi erronément conclu que Les conséquences était un livre biaisé et par conséquent peu lu en France. En contextualisant les réactions au livre de Keynes dans les débats politiques français sur la paix de Versailles, cet article démontre qu'en fait, le livre a été considérablement discuté en 1920 et qu'il a réuni l'appui des économistes et de la Gauche. Par ailleurs, l'article problématise l'idée que Keynes fut un germanophile en analysant comment ses réseaux parisiens l'ont aidé à publier la traduction des Conséquences dans la Nouvelle revue française.
Patient recruitment to a diabetic retinopathy screening trial through optimised patient information materials: an embedded study within a trial (SWAT)
Authors: Sheridan Rebecca , Knapp Peter , Bower Peter , Madurasinghe Vichithranie , Broadbent Deborah M , Awoyale Lola , Wang Amu , Moitt Tracy ,   on behalf of the ISDR Trial Group
Published: July 2020

Background: Printed participant information about trials is often technical, long and difficult to navigate. Optimisation and user testing can improve information materials, and may improve participant understanding and rates of recruitment. Methods: A study within a trial (SWAT) was undertaken within the ISDR trial. Potential participants in the ISDR trial were randomised to receive either the standard trial information or revised information that had been optimised through information design and user testing. Results: A total of 3,169 patients were randomised in the SWAT. Recruitment rates to the ISDR trial were 25.3% in the optimised information group and 26.1% in the standard information group (odds ratio 0.951; 95% CI 0.752 to 1.201; p=0.672). Clinic attendance rates were 71.6% in the optimised information group and 69.3% in the standard information group (OR 1.145; 95% CI 0.885 to 1.480; p=0.304). Conclusions: Optimisation of participant information through information design and user testing did not affect rate of recruitment to the host ISDR trial. Registration: ISRCTN ID ISRCTN87561257; registered on 08 May 2014.
Precision medicine implementation and research-practice partnerships: implications of measurement scale differential item functioning
Authors: Mogaka John J. O. , Chimbari Moses J. 
Published: July 2020

Background: Omics-based biomarkers (OBMs) inform precision medicine (PM). As omics-based technologies gradually move into clinical settings, however, a co-occurrence of biomedical research and clinical practice is likely an important variable in the implementation of PM. Currently, little is known about the implications of such research-practice co-occurrence. Methods: This study used data collected from a pilot study designed to inform a full-scale PM implementation study through the validation of the measurement tool. It applied item response theory (IRT) methods to assess the tool’s reliability and measurement invariance across two study subgroups associated with research and practice settings. Results: The study sample consisted of 31 participants. Measurement invariance assessment was through differential item functioning (DIF) analysis with bootstrapping through Monte Carlo simulation. Overall, 13 out of 22 items that formed the PMI scale had DIF at significance level α=0.25. Item response functions (IRFs) revealed how each subgroup members responded to scale items and their attitudes towards factors that influence PM implementation. Conclusions: Attitudinal similarities and differences towards factors influencing PM implementation amongst those in biomedical research as compared with those in practice were established. Results indicated PM implementation knowledge that is unique and common to both groups. The study established the validity and reliability of the new PM implementation measurement tool for the two subgroups.
Assessing pain in rabbits: how well does the Rabbit Grimace Scale work in the veterinary practice?
Authors: Shaw Danielle , Parkes Jessica , Reynolds Helen 
Published: July 2020

Background: Pain recognition in rabbits (Oryctolagous cuniculi) can be a challenging task for the registered veterinary nurse (RVN) and can often result in the delivery of suboptimal nursing care if pain goes undetected. Although the Rabbit Grimace Scale (RbtGS) can assist in pain assessment, it is a tool that is currently underutilised in practice. Aims: The aim of this research was to evaluate the efficacy of the RbtGS to assess if it is useful in the veterinary practice to improve rabbit welfare standards. Methods: 31 individuals, 25 student veterinary nurses and six RVNs participated, taking RbtGS scores for 19 rabbits through either live or video observations. The rabbits were either healthy or experiencing a pre-existing illness or health condition as assessed by a veterinary surgeon. Results: The RbtGS scores indicated that the majority of participants were unable to accurately identify the rabbits most likely to be in pain, suggesting that it may not be an optimal tool in rabbit pain assessment. However, RVNs who had more experience in practice were better at identifying signs of pain and stress in the rabbits. Conclusion: Experience and ongoing education is invaluable to improve rabbit care. There is a need for a veterinary rabbit pain score system in order to standardise pain management across species.