bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fear‐avoidance beliefs: A predictor for postpartum lumbopelvic pain
Authors: Fernando Mia , Nilsson‐Wikmar Lena , Olsson Christina B. 
Published: June 2020

AbstractObjectiveTo evaluate potential prognostic factors of self‐reported lumbopelvic pain 6 months postpartum for pregnant women with and without lumbopelvic pain.MethodsQuestionnaires were answered at gestational weeks 34–37 and again at 6 months postpartum. Psychosocial determinants and lumbopelvic pain symptoms were investigated using a visual analogue scale to assess pain intensity, and further using the Disability Rating Index, the Nottingham Health Profile, the Pain Catastrophizing Scale and the Fear‐Avoidance Beliefs Questionnaire. Logistic regression analysis was used to analyse the data.ResultsOf the 260 women who answered the questionnaires on both occasions, 186 did not suffer from lumbopelvic pain 6 months after pregnancy. The remaining 74 did. The results of the logistic regression analysis showed that fear‐avoidance beliefs was a significant predictor of lumbopelvic pain 6 months postpartum, with an odds ratio of 1.060 (p ≤ .05).ConclusionWomen with high fear‐avoidance beliefs at 34–37 weeks of gestation had a higher risk of having lumbopelvic pain at 6 months postpartum. We theorize that early lumbopelvic pain intervention postpartum may be important in avoiding chronicity. Women at risk can be identified through clinically relevant questions which may help the clinician to choose appropriate rehabilitation strategies.
Harnessing synthetic biology to enhance heterologous protein expression
Authors: Zarzhitsky Shlomo , Jiang Alex , E. Stanley Elizabeth , H. Hecht Michael 
Published: June 2020

AbstractThe ability to express heterologous proteins in microbial hosts is crucial for many areas of research and technology. In most cases, however, successful expression and purification of the desired protein require fusion to another protein. To date, all fusion partners have been chosen from natural sequences, which evolved for other purposes, and may not be optimal fusion partners. However, the rise of synthetic biology and protein design make it possible to design and optimize fusion proteins using novel sequences that did not arise in nature. Here, we describe a series of De novo Expression Enhancer Proteins (DEEPs) that facilitate high‐level expression and facile purification of heterologous proteins and peptides. To test the DEEP system, a de novo protein was fused to several target proteins covering a range of sizes and solubilities. In all cases, fusions to DEEP outperformed fusions to SUMO, a commonly used natural fusion partner. The availability of novel proteins that can be engineered for specific fusion applications could be beneficial to enhance the expression of a wide range of heterologous proteins.
A multicenter, phase I, pharmacokinetic study of osimertinib in cancer patients with normal renal function or severe renal impairment
Authors: Vishwanathan Karthick , Sanchez‐Simon Inmaculada , Keam Bhumsuk , Penel Nicolas , de Miguel‐Luken Maria , Weilert Doris , Mills Andrew , Marotti Marcelo , Johnson Martin , Ravaud Alain 
Published: June 2020

AbstractOsimertinib is a third‐generation, irreversible, oral epidermal growth factor receptor (EGFR)‐tyrosine kinase inhibitor (TKI) that potently and selectively inhibits both EGFR‐TKI sensitizing and EGFR T790M and has demonstrated efficacy in non‐small cell lung cancer (NSCLC) central nervous system metastases. In this phase I study, we assessed the effects of normal renal function (NRF) and severe renal impairment (SRI) on the pharmacokinetics (PK) of osimertinib in patients with solid tumors. Part A: patients with NRF (creatinine clearance [CrCL] ≥90 mL/min), and SRI, (CrCL <30 mL/min), received a single 80‐mg oral dose of osimertinib and standard PK measures were assessed. Part B: patients with SRI were treated for 3 months to obtain safety data, if deemed clinically appropriate. The geometric mean osimertinib plasma concentrations were higher in patients with SRI (n = 7) vs NRF (n = 8) and were highly variable. Osimertinib exposure based on Cmax and area under the plasma concentration‐time curve, was 1.19‐fold (90% CI: 0.6, 2.0) and 1.85‐fold (90% CI: 0.9, 3.6), respectively, higher for patients with SRI vs patients with NRF, with no clear correlation between CrCL and exposure. No new safety signals were identified after 12 weeks of osimertinib 80 mg continuous dosing. PK parameters pooled across this study and other phase I, II, and III osimertinib clinical studies (exploratory population PK analysis), showed minimal correlation between CrCL and total clearance. In conclusion, no dose adjustment is required for osimertinib for patients with SRI.
A data‐based private learning framework for enhanced security against replay attacks in cyber‐physical systems
Authors: Zhai Lijing , Vamvoudakis Kyriakos G. 
Published: June 2020

SummaryThis article develops a data‐based and private learning framework of the detection and mitigation against replay attacks for cyber‐physical systems. Optimal watermarking signals are added to assist in the detection of potential replay attacks. In order to improve the confidentiality of the output data, we first add a level of differential privacy. We then use a data‐based technique to learn the best defending strategy in the presence of worst case disturbances, stochastic noise, and replay attacks. A data‐based Neyman‐Pearson detector design is also proposed to identify replay attacks. Finally, simulation results show the efficacy of the proposed approach along with a comparison of our data‐based technique to a model‐based one.
Wrinkled Flower‐Like Reduced Graphene Oxide for High‐Performance Supercapacitors
Authors: Lai Liuqin , Su Siyu , Li Rong , Dai Huimin , Zhu Xiaohong 
Published: June 2020

AbstractThe preparation of reduced graphene oxide (rGO) by an oxidation‐reduction chemical reaction is very extensive. However, during the oxidation process, the obtained graphene oxide (GO) is usually not uniform in size and contains some incompletely oxidized graphite particles. To obtain uniformly small‐sized GO and remove impurities, we put forward here a simple suction filtration process, that is, when GO passes through the filter, it is preferentially selected. In this way, we provide a facile but effective method for the screening of GO and then obtain wrinkled flower‐like rGO (WF rGO) with excellent electrochemical performance. We also perform a design of experiments to optimize the reduction procedure. It is found that such factors as the reaction time, temperature, reductant and KOH content all affect the microstructure and electrochemical properties of rGO. With the optimized reduction procedure used, the specific capacitance of rGO can reach 231 F/g at the current density of 0.5 A/g. Furthermore, through the suction filtration along with the optimization of reduction, the WF rGO shows a much higher specific capacitance of 272 F/g. On this basis, the energy density of a symmetric rGO//rGO capacitor device arrives at 10.9 Wh/kg at a power density of 0.5 kW/kg and 8.2 Wh/kg at 12.6 kW/kg, and the capacitance keeps 91.5 % after 10,000 cycles. Moreover, the WF rGO//WF rGO device possesses a significantly higher energy density of 12.1 Wh/kg at a power density of 0.5 kW/kg and 9.7 Wh/kg at 24.2 kW/kg, and the capacity perfectly remains 94 % of its initial value after 10,000 cycles.
Chalcone‐Quinoline Conjugates as PotentialT. cruziCruzipain Inhibitors: Docking Studies, Molecular Dynamics and Evaluation of Drug‐Likeness
Authors: Yepes Andrés F. , Quintero‐Saumeth Jorge , Cardona‐G Wilson 
Published: June 2020

AbstractWe reported in a previous work the synthetic route of a novel series of conjugates based on chalcone‐quinoline, some of them were active againstT. cruzi, even more active than the clinical drug benznidazole. Those results motivated us to pursue further computational studies. Thus, molecular docking was used to determine thein‐silicoinhibition effects for the compounds against cruzipain (PDB:3IUT), an important druggable target for antiparasitic diseases. Notably, the docking results showed that the most experimental active compounds within two series,1 a–fand2 a–f, namely (E)‐1‐(3,4‐dimethoxyphenyl)‐3‐(4‐((9‐(quinolin‐8‐yloxy)nonyl)oxy)phenyl)prop‐2‐en‐1‐one (1 e) and (E)‐3‐(furan‐2‐yl)‐1‐(4‐((5‐(quinolin‐8‐yloxy)pentyl)oxy)phenyl)prop‐2‐en‐1‐one (2 c), also have the highest docking score (−7.3 and −7.4 kcal mol−1, respectively). The good correlation between docking and the experimental data profile lead us to propose inhibition of cruzipain as the potential mechanism of action for the novel conjugates. By combining molecular dynamics with MM/PBSA methods, the stability and rationality of molecular docking studies were validated, and drug‐likeness studies showed suitable pharmacokinetics properties.
Photoelectrochemical Activity of Ag Coated 2D‐TiO2/RGO Heterojunction for Hydrogen Evolution Reaction and Environmental Remediation
Authors: Saquib Mohammad , Kaushik Ravinder , Halder Aditi 
Published: June 2020

AbstractIntermittent nature of renewable energy led us more to incline over energy conversion and storage. Thus, use of solar radiation towards energy conversion e. g. hydrogen evolution, environmental‐remediation etc. are emerging areas where the materials should be capable of absorbing light energy and transform this absorbed energy into other application. In the present work, the photoelectrochemical and photocatalytic activity of the Ag/TiO2 /RGO catalyst for hydrogen evolution reaction (HER) and methyl orange dye degradation has been reported. Ag/TiO2 /RGO catalyst showed the highest current density for HER which was ca. 2 and 3 times more than Ag NPs and TiO2 nanoflakes, respectively. The interfacial charge transfer between RGO‐TiO2‐Ag hetero‐junction actually improves the charge separation and increases both the photocatalytic activity and hydrogen generation. The composite was also equally capable to degrade environmental pollutant and with the addition of silver, methyl orange dye degradation percentage enhances from 8.9 % (TiO2 nanoflakes) to 81 % (for Ag/TiO2/RGO) with the increment in rate constant from 9.38 X 10−4 (TiO2 nanoflakes) to 1.69×10−2 min−1.
Altering the Electrocatalytic Activity of Plasmonic Cu/Cu2O Nanocomposites towards Water Splitting through Surface Functionalization with Various Amino Acids
Authors: Kumar Pavitra V. , Ingole Pravin P. 
Published: June 2020

AbstractPresent study explores stabilization of copper/cuprous oxide nanomaterials using amino acids as capping agents. The one‐pot and time efficient synthesis method have been employed to synthesize amino acids functionalized copper nanomaterials. The nanomaterials are composed of both copper (0) and copper (I) species and are stable towards environmental oxidation under ambient conditions. Eight different amino acids were used for surface functionalization of the Cu/Cu2O nanocomposites where the type of amino acids are found to play an important role in manipulating the morphology, crystalline nature and the optical properties of the synthesized nanocomposites. Moreover, these materials are tested for electrochemical water splitting process and are found superior to traditional Cu‐based electro‐catalysts reported in literature. The capping with amino acids lead to modification in the electro‐chemical parameters such as charge carrier density, flat band potential, electrochemical surface area, etc. activity dependent on amino acid used. Among these amino acids, Alanine capped nanocomposites gave highest current density of 125±5 mA cm−2 at an over potential of −0.4 V vs. RHE.
The Study on Encapsulation of Copper Nanoparticles in Modified Poly‐Styrene Resin Metrix and its Catalytic Evaluation in Microwave‐Assisted Sonogashira Coupling
Authors: Patel Sunil B. , Vasava Dilip V. 
Published: June 2020

AbstractWe have synthesized Cu@Fun.XAD‐16 resin and typified the catalyst by using SEM, HR‐TEM, XRD, RAMAN, XPS, EDX and FT‐IR. From the analysis, we have found the size of zero ‐valent copper nanoparticles was between 10–20 nm, from the XPS analysis, it was confirmed that the Cu was present in both zero‐valent and oxide form. After ensuring the encapsulation we have applied the catalyst in the sonogashira coupling reaction between terminal alkynes and acyl chloride. We have achieved an excellent yield of ynones up to 98 % in the sonogashira coupling reaction by using conventional microwave under solvent‐free conditions. In post reaction TEM, XPS and XRD were studied to ensure the stability of the synthesized catalyst. From the post‐analysis, we have found that there was no notable change take place in the catalyst. We have developed an energy‐efficient and rapid sustainable protocol for the access of various substituted ynones.
Tandem Michael‐Type Reactions with 3‐Substituted Coumarins: Phosphorylation Protocol
Authors: Petkova‐Yankova Nevena I. , Nikolova Rositca D. 
Published: June 2020

AbstractA tandem hydrogenation / phosphorylation reactions with 3‐substituted 2‐oxo‐2H‐1‐benzopyranes and diethyl phosphorochloridate is described. The reaction proceeds with high regioselectivity for the O‐phosphorylation product in very good yield. Bromo derivatives of the studied 2‐oxo‐2H‐1‐benzopyranes were applied in phosphorylation reaction under Arbuzov reaction conditions, affording O‐phosphorylation product. One‐pot reactions with electrophiles as ethyl chloroformate and N‐bromosuccinimide are also reported.
Facile Synthesis of a NiCo2O4 Nanoparticles Mesoporous Carbon Composite as Electrode Materials for Supercapacitor
Authors: Nguyen Nghia V. , Tran Thu V. , Luong Son T. , Pham Thao M. , Nguyen Ky V. , Vu Thao D. , Nguyen Hieu S. , To Nguyen V. 
Published: June 2020

AbstractCombination the materials together is a direct and forceful strategy to improve the electrochemical properties of each raw material. Herein, we present the method of hydrothermal process and treatment/calcination combination that is easy to synthesize a NiCo2O4 nanoparticles‐mesoporous carbon composite (C/NiCo2O4). The result study electrochemical properties of materials revealed that the C/NiCo2O4 composite has excellent electrochemical properties compare with pristine NiCo2O4 or carbon. In particular, maximum specific capacitance of C/NiCo2O4 material at a current density of 1 A.g−1 is 204.28 F.g−1, meanwhile the Cs of carbon and NiCo2O4 are 25.06 F.g−1 and 178.78 F.g−1, respectively. In addition, C/NiCo2O4 material also showed excellent capacitance retention, Cs maintained to 90.35% after 3000 charge‐discharge continuous cycles. The results show that the C/NiCo2O4 is a promising material for application as supercapacitor electrode.
Green and Efficient Iron‐Catalysed Synthesis of Polyfunctionalized Benzofuran‐4(5H)‐one Derivatives via Cross‐Dehydrogenative Coupling
Authors: Singh Manjit , Yadav Vijay B. , Danish Ansari Mohd , Malviya Manisha , Siddiqui I. R. 
Published: June 2020

AbstractAn efficient and facile protocol for the synthesis of a multi‐functional 6,7‐dihydrobenzofuran‐4(5H)‐ones and their derivatives using iron salt in the presence of air via reactions of readily available dimedone, acetophenone and isocyanide as starting materials. This approach illustrate operational simplicity, offering a modified and expedient methodology for the direct construction of synthetically useful benzofuran derivatives in good to excellent yields. Benzofuran derivatives have many biological importance. This documented strategy, provide a cost effective and environmentally benign alternative to the other existing method.
Methyl Salicylate Functionalized Magnetic Chitosan Immobilized Palladium Nanoparticles: An Efficient Catalyst for the Suzuki and Heck Coupling Reactions in Water
Authors: Hasan Kamrul 
Published: June 2020

AbstractA heterogeneous catalyst was fabricated by immobilization of chitosan (CS) on magnetic Fe3O4 following the deposition of palladium nanoparticles on its modified surface. The prepared catalyst was characterized using Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), X‐ray diffractometer (XRD), scanning electron microscopy (SEM) and energy dispersive X‐ray spectroscopy (EDX). The catalyst was investigated for the Suzuki‐Miyaura and Heck‐Mizoroki cross‐coupling reactions and afforded arylated products with high turnover number TON (980) and turnover frequency TOF (980 h−1). The optimized catalytic system was found practical and green as catalyst loading was low (0.10 mol%), water used as solvent and the catalyst was separated with external magnet. A wide variety of aryl halides including electro withdrawing and releasing groups were investigated and found excellent to good yield of Suzuki and Heck cross‐coupled products. Furthermore, the catalyst was recovered and reused up to seven times for Suzuki coupling reactions with 97% efficiency.
Shedding Light on Metal‐Based Nanoparticles in Zebrafish by Computed Tomography with Micrometer Resolution
Authors: Cörek Emre , Rodgers Griffin , Siegrist Stefan , Einfalt Tomaz , Detampel Pascal , Schlepütz Christian M. , Sieber Sandro , Fluder Pascal , Schulz Georg , Unterweger Harald , Alexiou Christoph , Müller Bert , Puchkov Maxim , Huwyler Jörg 
Published: June 2020

AbstractMetal‐based nanoparticles are clinically used for diagnostic and therapeutic applications. After parenteral administration, they will distribute throughout different organs. Quantification of their distribution within tissues in the 3D space, however, remains a challenge owing to the small particle diameter. In this study, synchrotron radiation‐based hard X‐ray tomography (SRμCT) in absorption and phase contrast modes is evaluated for the localization of superparamagnetic iron oxide nanoparticles (SPIONs) in soft tissues based on their electron density and X‐ray attenuation. Biodistribution of SPIONs is studied using zebrafish embryos as a vertebrate screening model. This label‐free approach gives rise to an isotropic, 3D, direct space visualization of the entire 2.5 mm‐long animal with a spatial resolution of around 2 µm. High resolution image stacks are available on a dedicated internet page (http://zebrafish.pharma-te.ch). X‐ray tomography is combined with physico‐chemical characterization and cellular uptake studies to confirm the safety and effectiveness of protective SPION coatings. It is demonstrated that SRμCT provides unprecedented insights into the zebrafish embryo anatomy and tissue distribution of label‐free metal oxide nanoparticles.
A New Mechanism of Light‐Induced Bubble Growth to Propel Microbubble Piston Engine
Authors: Yan Xin , Xu Jinliang , Meng Zhijun , Xie Jian , Wang Hao 
Published: June 2020

AbstractRadiation pressure refers to the momentum transfer of photons during light “particles” impacting a surface. The force is too small to drive microengines. Different from the classical radiation pressure, the indirect radiation pressure (Fm) is introduced, coming from the momentum change of light‐induced bubble expansion. Fm is shown to obey Fm ∼ (I·rb)2, behaving faster growth of indirect radiation pressure versus light intensity I and bubble radius rb. An effective bubble size range is identified for Fm to suppress other forces for bubble in liquid. The top laser irradiation on nanofluid is used in this experiment. A well‐defined bubble pulsating flow, being a new principle of bubble piston engine, is demonstrated. During pulse on (≈ns scale), Fm exceeding other forces generates an extremely large acceleration, which is three to four orders larger than the gravity acceleration, propelling the bubble traveling downward. During pulse off, the bubble is floating upward due to the nonexistence of Fm. In such a way, the piston engine sustains the oscillating ranges of 38–347 µm for bubble diameters and 2.7–457.9 µm for traveling distances of piston. This work is useful to manipulate bubble dynamics in solar energy systems, and can find various applications in optofluidics.
Ionic Liquid‐Directed Nanoporous TiNb2O7 Anodes with Superior Performance for Fast‐Rechargeable Lithium‐Ion Batteries
Authors: Tao Runming , Yang Guang , Self Ethan C. , Liang Jiyuan , Dunlap John R. , Men Shuang , Do‐Thanh Chi‐Linh , Liu Jixing , Zhang Yiman , Zhao Sheng , Lyu Hailong , Sokolov Alexei P. , Nanda Jagjit , Sun Xiao‐Guang , Dai Sheng 
Published: June 2020

AbstractNanoporous TiNb2O7 (NPTNO) material is synthesized by a sol–gel method with an ionic liquid (IL) as the nanoporous structure directing template. NPTNO exhibits a high reversible capacity of 210 mAh g–1 even at the charging rate of 50 C and an excellent cyclability of half‐cell capacity retention of 74% for 1000 cycles at 5 C and LiNi0.5Mn1.5O4‐coupled full‐cell capacity retentions of 81% and 87% for 1000 cycles at 1 C and 2 C, respectively. The studies of the 1000 cycled NPTNO electrode illustrate that the IL‐directed mesoporous structure can enhance the cyclability of NPTNO cells due to the alleviation of repetitive mechanical stress and volume fluctuation induced by the repetitive Li+ insertion‐extraction processes. The measured Li+ diffusion coefficients from the galvanostatic intermittent titration technique suggest that the IL‐templating strategy indeed ensures the fast rechargeability of NPTNO cells based on the fast Li+ diffusion kinetics. Benefitting from the nanoporous structure, NPTNO with unhindered Li+ diffusion pathways achieves a superior rate capability in the titanium‐based oxide materials and the best full‐cell cyclability in the TNO materials. Therefore, the templating potential of IL is demonstrated, and the superb electrochemical performance establishes the IL‐directed NPTNO as a promising anode candidate for fast‐rechargeable LIBs.
Deriving secondary traits of industry 4.0: A comparative analysis of significant maturity models
Authors: Simetinger František , Zhang Zuopeng (Justin) 
Published: June 2020

AbstractThe potential of Industry 4.0 concept is represented by increased productivity, improved cost efficiency, or higher product attractiveness. The adoption of this concept is related to a high number of challenges and risks. A possible solution to address these challenges and risks is the adoption or implementation of this concept using the maturity models. The maturity models use various approaches to Industry 4.0 with concepts and procedures varying in every maturity model. However, there still exist divergences in terms of their impact on the organizational units. This research conducts the comparative analysis of significant maturity models to identify generally shared traits of Industry 4.0 that are common to the majority of the analyzed maturity models. In addition, it discusses the impact of Industry 4.0 on the business informatics unit in organizations.
Neuartige Bemessungsmethode für Hohlprofilquerschnitte und ‐stäbe
Authors: Taras Andreas , Toffolon Andrea 
Published: June 2020

AbstractDer Wunsch nach einem vermehrten Einsatz von hochfesten, besonders dünnwandigen und/oder speziell geformten Hohlprofilen führte in den letzten Jahren zur Überprüfung und Revision bestehender, traditioneller Bemessungsregeln, u. a. für den Querschnitts‐ und Bauteilnachweis. Für die – nun deutlich häufiger auftretenden – schlanken Querschnitte der Klassen 3 und 4 stellen die als konservativ erkannten Bemessungsregeln teilweise ein Hindernis für die weitere Verbreitung der neuen Bauweisen dar. Das EU‐RFCS‐geförderte Projekt HOLLOSSTAB (2016–2019) setzte sich das Ziel, durch den spezifischen Einsatz der Kombination von einfachen numerischen Berechnungsroutinen mit experimentell validierten, analytischen Bemessungsformeln eine deutliche Verbesserung der Bemessungsverfahren zu erzielen. Das Ergebnis dieser Arbeiten ist die Generalised Slenderness‐based Resistance Method für die Bemessung von Hohlprofilen unter allgemeiner Druck‐ und Biegebeanspruchung; sie wird in diesem Übersichtsaufsatz zum Projekt vorgestellt und diskutiert.