bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interrater Agreement of The Copenhagen Triage Algorithm
Authors: Borchsenius Julie Inge-Marie Helene , Hasselbalch Rasmus , Lind Morten , Ravn Lisbet , Kallemose Thomas , Schultz Martin , Rasmussen Lars Simon , Iversen Kasper 
Published: August 2020

Abstract
Introduction Systematic triage is performed in the Emergency Department (ED) to assess the urgency of care for each patient. The Copenhagen Triage Algorithm (CTA) is a newly developed, evidence-based triage system, however the interrater agreement remains unknown. Method This was a prospective cohort study. The collection of data was conducted in the three sections (Acute/Cardiology, Medicine and Surgery) of the ED of Herlev Hospital. Patients were assessed independently by two different nurses using CTA. The interrater variability of CTA was calculated using Fleiss kappa. The analysis was stratified according to less or more than 2 years of ED experience. Results A total of 110 patients were included of which 10 were excluded due to incomplete data. The raters agreed on triage category 80 % of the time corresponding to a kappa value of 0.70 (95% confidence interval 0.57-0.83). Stratified on ED sections, the agreement was 83 % in the Acute/Cardiology section corresponding to a kappa value of 0.73 (0.55-0.91), 79 % in the Medicine section corresponding to a kappa value of 0.64 (0.39-0.89) and 0.56 % in the Surgery section corresponding to a kappa value of 0.56 (0.21-0.90). The experienced raters had an interrater agreement of 0.73 (0.56-0.90), while the less experienced raters had an agreement of 0.76, (0.28-1.24). Conclusion A substantial interrater agreement was found for the Copenhagen triage algorithm.
Urinary Tract Infection Caused by Bacteria in Pregnant women from Kassala State, Sudan
Authors: Musa Suhndh Ahmed 
Published: August 2020

Abstract
Background Urinary tract infection is a common disease prevailing in pregnancy: microorganisms, mostly bacteria, cause it. Result The prevalence of urinary tract infection was very high (70.9%). The most common isolate were Listeria spp. (38.85%) and Streptococcus spp. (28.06%), less common isolates were Vibrio cholera, Neisseria sp. and E. coli with percentages (16.55%,10.07% and 6.47%), respectively. Conclusion five bacteria species associated with urinary tract infection in pregnant women recorded in this study. Vibrio cholera and Neisseria sp.it was first time recorded in Sudan.
Optogenetic stimulation of the motor cortex alleviates neuropathic pain in rats of infraorbital nerve injury with/without CGRP knock-down
Authors: Islam Jaisan , KC Elina , Oh Byeong Ho , Kim Soochong , Hyun Sang-hwan , Park Young Seok 
Published: August 2020

Abstract
Background

Previous studies have reported that electrical stimulation of the motor cortex is effective in reducing trigeminal neuropathic pain; however, the effects of optical motor cortex stimulation remain unclear.

Objective

The present study aimed to investigate whether optical stimulation of the primary motor cortex can modulate chronic neuropathic pain in rats with infraorbital nerve constriction injury.

Methods

Animals were randomly divided into a trigeminal neuralgia group, a sham group, and a control group. Trigeminal neuropathic pain was generated via constriction of the infraorbital nerve and animals were treated via selective inhibition of calcitonin gene-related peptide in the trigeminal ganglion. We assessed alterations in behavioral responses in the pre-stimulation, stimulation, and post-stimulation conditions. In vivo extracellular recordings were obtained from the ventral posteromedial nucleus of the thalamus, and viral and α-CGRP expression were investigated in the primary motor cortex and trigeminal ganglion, respectively.

Results

We found that optogenetic stimulation significantly improved pain behaviors in the trigeminal neuralgia animals and it provided more significant improvement with inhibited α-CGRP state than active α-CGRP state. Electrophysiological recordings revealed decreases in abnormal thalamic firing during the stimulation-on condition.

Conclusion

Our findings suggest that optical motor cortex stimulation can alleviate pain behaviors in a rat model of trigeminal neuropathic pain. Transmission of trigeminal pain signals can be modulated via knock-down of α-CGRP and optical motor cortex stimulation.
Glycated hemoglobin variability, mean HbA1c and heart failure in patients with type 2 diabetes
Authors: Lin You-Ting , Huang Wei-Lun , Wu Hung-Pin , Chang Man-Ping , Chen Ching-Chu 
Published: August 2020

Abstract
Background: Heart failure (HF) is a common presentation in patients with type 2 diabetes mellitus (T2DM). Previous studies revealed that HbA1c level is significantly associated with HF. However, little is known about the association between HbA1c variability and HF. We aimed to evaluate the association of HbA1c variability and mean HbA1c with HF in patients with T2DM. Methods: Using Diabetes Share Care Program data, patients with T2DM had mean HbA1c (HbA1c-Mean), HbA1c variability (tertiles of HbA1c-SD and HbA1c-adjSD) within 12-24 months during 2001-2008 were included. The cutoffs of HbA1c-Mean were set at <7%, 7-7.9%, and ≥8%. Hazard ratios (HRs) for HF during 2008-2018 were estimated using Cox proportional hazards models. Results: A total of 3824 patients were included, of whom 315 patients developed HF during the 11.72 years observation period. The associated risk of HF increased with tertiles of HbA1c variability and cutoffs of HbA1c-Mean. In mutually adjusted models, HbA1c-Mean showed a consistent dose-response association with HF, while the association of HbA1c variability with HF disappeared. Among patients with HbA1c-Mean < 7%, the associated risk of HF in patients with HbA1c variability in tertile 3 was comparable to patients with HbA1c-Mean ≥8%. Conclusions: Mean HbA1c was an independent predictor of HF and not explained by HbA1c variability. In addition to absolute HbA1c level, targeting on stability of HbA1c in patients with well glycemic control was also important for the development of HF in patients with T2DM.
Assessment of the Structured Clinical Interview (SCID) for DSM-5 for Somatic Symptom Disorder in General Hospital Outpatient Clinics in China
Authors: Jiang Yinan , Wei Jing , Fritzsche Kurt , Toussaint Anne Christin , Li Tao , Cao Jinya , Zhang Lan , Zhang Yaoyin , Chen Hua , Wu Heng , Ma Xiquan , Li Wentian , Ren Jie , Lu Wei , Leonhart Rainer 
Published: August 2020

Abstract
Background: It is still unknown whether the “Somatic symptom disorders (SSD) and related disorders” module of Structured clinical interview for DSM-5, research version (SCID-5-RV) is valid in China. This study aimed to assess the SCID-5-RV for SSD in general hospital outpatient clinics in China.Methods: This multicenter cross-sectional study was conducted in the outpatient clinics of nine tertiary hospitals in Beijing, Jincheng, Shanghai, Wuhan, and Chengdu, between May 2016 and March 2017. The “SSD and related disorders” module of SCID-5-RV was translated, reversed-translated, revised, and used by trained clinical researchers to make a diagnosis of SSD. Several standardized questionnaires measuring somatic symptom severity, emotional distress, and quality of life were used to compare with SCID-5-RV.Results: A total of 699 patients were recruited, and 236 were diagnosed with SSD. Of these, 46 had mild SSD, 78 had moderate SSD, 100 had severe SSD, and 12 were excluded due to incomplete data. SCID-5-RV for SSD correlated high with somatic symptom severity, emotional distress, and quality of life (all P<0.001), and could distinguish non-severe forms of SSD from severe ones. Conclusions: This study suggests that SCID-5-RV for SSD can distinguish SSD from non-SSD patients, and severe patients from non-severe patients. It has good discriminative validity with other tools and reflects the DSM-5 diagnostic approach that emphasizes excessive emotional, thinking, and behavioral responses related to symptoms.
Primary Thymus Tumors: Retrospective Case Analysis at a Reference Center in Latin America, 2011 – 2019
Authors: Scarpetta-Gonzalez Diego F. , Morales Eliana Isabel , Sua Luz Fernanda , Velásquez Mauricio , Sanguiovanni Saveria , Fernández-Trujillo Liliana 
Published: August 2020

Abstract
BackgroundThymic tumors are unusual neoplasms, representing 0.2% to 1.5% of tumors in humans, but correspond to 20% of mediastinal tumors and 50% of those that occur in the anterior mediastinum. They tend to appear around the fourth and fifth decades of life without gender predilection. Up to 30% of patients are asymptomatic, therefore many are incidentally diagnosed. Radical thymectomy is the treatment of choice with high survival rates when detected in the early stages. Methods This was a retrospective descriptive study, including 18 adult patients’ diagnosis of thymic neoplasm, who were managed with surgical resection from 2011 to 2019. Information about demographics, clinical characteristics, imaging findings, surgical and medical management, plus histological findings was obtained and reported. Results18 patients with thymic tumors were included, of which specific histologic studies reveled thymomas, carcinomas, neuroendocrine tumors, thymolipoma and thymic cyst. Mean age was 52.7 years, with a predominance of male population. The main symptom was dyspnea, followed by cough and chest pain. Paraneoplastic syndromes such as myasthenia gravis, aplastic anemia and Cushing syndrome were reported. 89% of cases were treated by radical thymectomy alone, while only 2 cases required chemotherapy and radiotherapy. There were no surgical complications. Mean hospital stay length was 11. 9 days, with only 1 mortality during hospital admission. 5-year survival rate was 81%. Conclusions The treatment of choice is radical thymectomy, which has been shown to positively impact patient mortality. Early detection is key to improve patient outcomes.
Identification and Validation of a Novel Metabolism‑Related Prognostic Signature in Hepatocellular Carcinoma
Authors: Wang Zhihao , Embaye Kidane Siele , Yang Qing , Qin Lingzhi , Zhang Chao , Liu Liwei , Zhan Xiaoqian , Zhang Fengdi , Wang Xi , Qin Shenghui 
Published: August 2020

Abstract
Background: Given that metabolic reprogramming has been recognized as an essential hallmark of cancer cells, this study sought to investigate the potential prognostic values of metabolism-related genes(MRGs) for hepatocellular carcinoma (HCC) diagnosis and treatment. Methods: The metabolism-related genes sequencing data of HCC samples with clinical information were obtained from the International Cancer Genome Consortium(ICGC) and The Cancer Genome Atlas (TCGA). The differentially expressed MRGs were identified by Wilcoxon rank sum test. Then, univariate Cox regression analysis were performed to identify metabolism-related DEGs that related to overall survival(OS). A novel metabolism-related prognostic signature was developed using the least absolute shrinkage and selection operator (Lasso) and multivariate Cox regression analyses . Furthermore, the signature was validated in the TCGA dataset. Finally, cox regression analysis was applied to identify the prognostic value and clinical relationship of the signature in HCC. Results: A total of 178 differentially expressed MRGs were detected between the ICGA dataset and the TCGA dataset. We found that 17 MRGs were most significantly associated with OS by using the univariate Cox proportional hazards regression analysis in HCC. Then, the Lasso and multivariate Cox regression analyses were applied to construct the novel metabolism-relevant prognostic signature, which consisted of six MRGs. The prognostic value of this prognostic model was further successfully validated in the TCGA dataset. Further analysis indicated that this signature could be an independent prognostic indicator after adjusting to other clinical factors. Six MRGs (FLVCR1, MOGAT2, SLC5A11, RRM2, COX7B2, and SCN4A) showed high prognostic performance in predicting HCC outcomes, and were further associated with tumor TNM stage, gender, age, and pathological stage. Finally, the signature was found to be associated with various clinicopathological features. Conclusions: In summary, our data provided evidence that the metabolism-based signature could serve as a reliable prognostic and predictive tool for overall survival in patients with HCC.
Demand and Supply Side Factors Associated with the Use of Contraceptive Methods in Pakistan: A Contemplative Study of Demographic and Health Surveys, 1990-2018
Authors: Jabeen Sadia , Rathor Adnan , Riaz Maria , Zakar Rubeena , Fischer Florian 
Published: August 2020

Abstract
Background
A remarkable decline in fertility rates has been observed in many countries, with a primary determinant being an increase in the use of contraceptives. Therefore, this study aims to assess the effect of demand and supply-side factors associated with the use of contraceptive measures in Pakistan.
Method:
Secondary data analysis of four data series of the Pakistan Demographic and Health Surveys (PDHS 1990–91, 2006–07, 2012–13, and 2017–18) were used. The data includes ever-married women aged 15–49 years who had given birth in the previous five years and participated in the family-planning module of the PDHS. A total number of 25,318 women were included in the analysis. Data was analysed by investigating the associations between independent variables (demand and supply-side factors) and the use of contraceptive measures through unadjusted Odds Ratios (OR) and adjusted OR (AOR).
Results
A majority of the women were illiterate and not in employment. There was an increase in the number of women who did not use contraceptive methods in rural areas over time. Among demand-side factors, the results indicated that, in 2012–13, women without media exposure were less likely to use contraceptives (OR 0.396, 95% CI 0.353–0.442), and the trend remains almost constant for 2017–18 (OR 0.432, 95% CI 0.391–0.477). These findings change slightly in the adjusted analysis (AOR 0.664, 95% CI 0.562–0.784) in 2012–13 and (AOR 0.654, 95% CI 0.483–0.885) in 2017–18; however, they still show a lower likelihood of using contraceptives without media exposure. Among supply-side factors, the results indicated that absence of transport (2012–13) and limited visits by family-planning workers over the previous 12 months (2006–07, 2012–13, and 2017–18) remained significant factors for not using contraceptive methods.
Conclusion
The results of the study indicate that certain demand and supply-side factors are associated with the use of contraceptive measures in Pakistan. It highlights the need for the provision of family-planning resources and further structural factors, particularly in remote areas.
Diagnostic accuracy of two commercially available rapid assays for detection of IgG and IgM antibodies to SARS-CoV-2 compared to ELISA in a low-prevalence population
Authors: Hackner Klaus , Errhalt Peter , Willheim Martin , Grasl Maria-Anna , Lagumdzija Jasmina , Riegler Waltraud , Ecker Michael , Wechdorn Matthias , Thalhammer Florian , Assadian Ojan 
Published: August 2020

Abstract
Background: New commercially available point-of-care (POC) immunodiagnostic tests are appearing, which may yield rapid results for anti-SARS-CoV-2 antibodies. The aim of this study was to evaluate the diagnostic accuracy of rapid antibody detection tests compared to a validated laboratory-based enzyme-linked immunosorbent assay (ELISA) and to investigate infections amongst healthcare workers (HCWs) after unprotected close contact to COVID-19 patients. Methods: Blood serum and whole blood of 130 participants were tested with NADAL® COVID-19 IgG/IgM Rapid Test and mö-screen 2019-NCOV Corona Virus Test against a validated ELISA test. Infection status was evaluated using real-time polymerase-chain-reaction.Results: Acute COVID-19 infection was detected in 2.4% of exposed HCWs. Antibody tests showed an overall frequency of IgG and IgM in 5.3%, with 1.6% asymptomatic infections. The NADAL® test showed a sensitivity (IgM/ IgG) of 100% (100%/ 100%), a specificity (IgM/ IgG) of 98.8% (97.6%/ 100 %), a PPV of 76.9% (57.1%/ 100%), an NPV of 100% (100%/ 100%), and a diagnostic accuracy of 98.8% (97.7%/ 100%). The mö-screen test had a sensitivity (IgM/IgG) of 90.9% (80%/ 100%), a specificity (IgM/IgG) of 98.8% (97.6%/ 100%), a PPV of 76.9% (57.1%/ 100%), an NPV of 99.6% (99.2%/ 100%), and a diagnostic accuracy of 98.5% (96.9%/ 100%). Conclusions: The frequency of COVID-19 infections in HCWs after unprotected close contact is higher than in the general population of a low-prevalence country. Both POC tests were useful for detecting IgG, but did not perform well for IgM, mainly due to false positive results.
Coexisting illness and COVID-19
Authors: Hu Rui , Han Zhiyang , Zhang Chunling , Ren Huajing , Chen Xiang , Yin Mingzhu 
Published: August 2020

Abstract
Background: Coronavirus disease 2019 (COVID-19) has rapidly spread throughout worldwide. Hypertension, diabetes, cardiovascular disease, and cerebrovascular disease were the most common coexisting illness among patients with severe SARS-CoV-2 infection. We aim to analyze the effect of them on the result of laboratory finding in patients with severe or critical SARS-CoV-2 infection.Methods: The date of a total of 49 patients who met the inclusion criteria from January 12 to March 20, 2020, from the first affiliated hospital of Harbin medical university were analyzed in our study.Results: Compared with patients without any coexisting illness, we found that PT levels were decreased in patients with cerebrovascular disease, hypertension or cardiovascular disease, and D-Dimer levels were decreased in patients with cerebrovascular disease, hypertension or diabetes. Similarly, LDH and ALT levels were lower in patients with cerebrovascular disease than that without any coexisting illness.Conclusions: Hypertension, diabetes, cardiovascular disease, and cerebrovascular disease are associated with an increased disease severity and risk of death in patients with COVID-19. Recently study also reported that the levels of PT, D-dimer, and LDH were increased and predicted the deterioration of disease in severe patients with SARS-CoV-2 infection. Interestingly, our results demonstrate that the levels of laboratory indicators such as PT, D-dimer, LDH and ALT were decreased in patients with coexisting illness than without any coexisting illness. It may give us the inaccurate result when we use those laboratory indicators to predict the deterioration of the patients and we need to pay more attention to it.
Genetic analysis of rice seedling traits related to machine transplanting under different seeding densities
Authors: Zhu Dan , Zhang Yuping , Xiang Jing , Wang Yaliang , Zhu Defeng , Zhang Yikai , Chen Huizhe 
Published: August 2020

Abstract
Background: Due to the diversity of rice varieties and cropping systems in China, the limitation of seeding density and seedling quality makes it hard to improve machine-transplanted efficiency. Previous studies have shown that indica and japonica varieties varied in machine transplanting efficiency and optimal seeding density. In this study, a RIL population derived from ‘9311’ and ‘Nipponbare’ were performed to explore the seedling traits variations and the genetic mechanism under three seeding densities. Results: The parents and RIL population exhibited similar trends as the seeding density increased, including seedling height and first leaf sheath length increases, shoot dry weight and root dry weight decreases. Among the 37 QTLs for six traits detected under the three seeding densities, 12 QTLs were detected in both three seeding densities. Five QTL hotspots identified clustered within genomic regions on chromosomes 1, 2, 4, 6 and 11. Specific QTLs such as qRDW1.1 and qFLSL5.1 were detected under low and high seeding densities, respectively. Detailed analysis the QTL regions identified under specific seeding densities revealed several candidate genes involved in phytohormones signals and abiotic stress responses. Whole-genome additive effects showed that ‘9311’ contributed more loci enhancing trait performances than ‘Nipponbare’, indicating ‘9311’ was more sensitive to the seeding density than ‘Nipponbare’. The prevalence of negative epistasis effects indicated that the complementary two-locus homozygotes may not have marginal advantages over the means of the two parental genotypes. Conclusions: Our results revealed the differences between indica rice and japonica rice seedling traits in response to seeding density. Several QTL hotspots involved in different traits and specific QTLs (such as qRDW1.1 and qFLSL5.1) in diverse seeding densities had been detected. Genome-wide additive and two-locus epistasis suggested a dynamic of the genetic control underlying different seeding densities. It was concluded that novel QTLs, additive and epistasis effects under specific seeding density would provide adequate information for rice seedling improvement during machine transplanting.
Diabetes and correlates of cardiovascular diseases among women aged 15-49 years in Benin: evidence from a Demographic and Health Survey
Authors: Ekholuenetale Michael , Nzoputam Chimezie Igwegbe , Barrow Amadou 
Published: August 2020

Abstract
Background: Sub-Saharan Africa (SSA) countries are facing an epidemiological shift from infectious diseases to chronic diseases, such as cardiovascular diseases (CVDs). The burden of CVDs in a population results from the prevalence of several factors. This study was to determine the association of diabetes and correlates with heart and lung diseases.Methods: We used Benin Demographic and Health Survey (BDHS) population-based cross-sectional data. BDHS 2017-18 is the fifth of its kind. A total of 7712 women of reproductive age were included in this study. Heart and lung diseases were the outcome variables. Percentage and logistic regression model were used to analyze the data. The level of statistical significance was set at 5%.Results: The prevalence of heart disease was 1.3% (95%CI: 1.0%-1.7%) and lung disease was approximately 1.5% (95%CI: 1.2%-1.9%). Women who had diabetes were also found to be 3.57 times significantly more likely to have heart disease when compared with those who do not have diabetes (AOR= 3.57; 95%CI: 1.51 – 8.45). Furthermore, women with diabetes were 4.55 times significantly more likely to also have lung diseases when compared with those who do not have diabetes (AOR= 4.55; 95%CI: 2.06 – 10.06). Women who had hypertension were found to be 3.18 times significantly more likely to have heart disease when compared with those who had no hypertension (adjusted odds ratio (AOR) = 3.18; 95%CI: 2.02 – 4.98).Conclusion: Diabetes was a key determinant of heart disease. Health policymakers and government need to focus on widespread prevention and control interventions of heart disease through improved screening for risk factors and early detection of CVDs especially among high-risk women. The government should also create nationwide awareness and educate people about CVDs and its fatality rate.