bluuebunny/crossref_metadata_2025_split huggingface dataset:
The coadministration of trehalose dibehenate and monosodium urate crystals promotes an antitumor phenotype in human-derived myeloid cells
Authors: Kodar Kristel , McConnell Melanie-Jane , Harper JL , Timmer Mattheus , Stocker Bridget 
Published: June 2020

© 2020 Australian and New Zealand Society for Immunology Inc. Trehalose dibehenate (TDB), a ligand for the macrophage-inducible C-type lectin, has shown promise as an adjuvant for preventative vaccines and also as an anticancer agent in murine assays. The potential for TDB to affect the antitumor immune response of human myeloid cells, however, has not been studied. We investigated the effect of the adjuvants TDB and monosodium urate (MSU) crystals on the protumor or antitumor immune phenotype of human monocytes, macrophages and monocyte-derived dendritic cells (Mo-DCs). TDB treatment alone led to an inflammatory response in all three cell types, which was most pronounced when using human monocytes, with MSU augmenting this response. TDB also decreased cell surface markers associated with a protumorigenic phenotype, with MSU showing some ability to augment this response. Notably, a significant reduction in CD115 was observed for all antigen-presenting cells upon TDB or MSU + TDB treatment. The potential to increase the antigen-presenting capabilities of the myeloid cells was also observed upon treatment with TDB and MSU + TDB, as indicated by the upregulation of cell surface markers such as CD86 for all three cell types and a favorable ratio of interleukin (IL)-12p40 to IL-10 for monocytes stimulated with MSU + TDB. There was no significant production of IL-12p40 by Mo-DC; however, in a mixed lymphocyte assay, MSU + TDB costimulation of Mo-DC led to a significant increase in CD4+ T-cell numbers and in the IL-12p40-to-IL-10 ratio. Taken together, these findings show for the first time the potential of MSU + TDB costimulation to favor a tumor-suppressive phenotype in human-derived myeloid cells.
Financial and Operating Working Capital: Unraveling Obscured Portion of Balance Sheet
Authors: Kashif Saeed  , Khan Areeba 
Published: June 2020

ABSTRACT
Purpose- The purpose of this study is to provide a new obscured aspect of financial working capital in working capital management, and investigate the association between financial and operating working capital with business performance. This paper also examines the interacting effect of net cash flow on this relationship. The current study introduces a modification in cash conversion cycle (CCC) by taking concealed trade advance payments.
Design/methodology/approach- This study employs fixed effect regression model, covering a sample of Automobile sector companies, listed at Pakistan Stock Exchange (PSX) for the period of fourteen years from 2005 to 2018. Secondary data is collected from companies’ financial annual reports, PSX website, and Balance sheet analysis of State Bank of Pakistan (SBP). The study is explanatory and deductive in nature. Financial working capital (FWC) and new measure of operating working capital (OWC) i.e. modified cash conversion cycle (mCCC) is introduced & empirically tested with 252 firm-year observations.
Findings- The regression results shows, a convex association between OWC & FWC, with business performance, in dearth of internal cash. However, after taking interacting effect of internal availability of cash, only FWC relation has become concave. The result also shows that mCCC provides a more realistic view of OWC.
Research limitations/implications- This study has considered, concealed trade prepayments only, further research could include other components in mCCC. Moreover micro, macro factors and status of the economy such as depression or boom may also affect the results of the research. The findings suggest that managers should separately deal operating & financial working capital. Firms’ performance can be enhanced, if Finance Manager Take account internal cash of the firm. In case of deficiency (sufficiency) of it, he should work to decrease (increase) the investment amount in operating working capital (financial working capital). Overall, the results will be helpful to the financial experts and business practitioner in analyzing, and utilization of their resources.
Originality/value- This study adds a new dimension in working capital by separating it into operating and financial working capital. The study also offers insights into the new knowledge of extension in CCC, role of concealed advance payments and internal cash flow, for class teachers and business practitioners. It will also describe the new avenues for further research in this field.

Key Words: Financial working capital, Operating working capital, Trade advanced payments and modified cash conversion cycle (mCCC).
RETROSPECTIVE EVALUATION OF SUCCESS OF IMPLANT SUPPORTED PROSTHESIS: EARLY RESULTS
Authors: Demirekin Zeynep Başağaoğlu , Findik Yavuz , Turkaslan S. Süha , Baykul Timuçin , Erken Merve 
Published: June 2020

Introduction: The interpretation of clinical results of dental implant supported prosthesis treatment is very crucial to be able to make a comparison between different implant systems and treatment options and furthermore to benefit the experiences of the other clinicians. However, the clinical outcomes of these studies should be reported in an objective way and be independent from the system used and also be prepared in accordance with certain criteria and standards that have been accepted scientifically world-wide for being reliable and describing long-term results.
Aim: Three-hundred and eighty-two consecutive NTA implants were performed on ninety-nine patients. The implants used in 2016 and the constructed restorations were retrospectively analyzed. In addition, the effect of the experience of clinician was evaluated related with the success of the implant therapy.
Materials and Method: This retrospective study was conducted in the Department of Prosthodontics Süleyman Demirel University. Three-hundred and eighty-two consecutive NTA implants were performed on ninety-nine patients. The implants used in 2016 and the constructed restorations were retrospectively analyzed.
Results: The implants were followed for at least 2 years. In total, 239 implants were inserted. It was found in 143 mandibles. Prosthetic restorations were determined to be partial prosthetics (219), single crown (81) and overdenture prosthetics (64). During the evaluation period, 6 implants failed before prosthetic treatment, ten decementations, six retentive screw loosening and five porcelain chipping were detected.
Discussion and Conclusions: The early results of our study are consistent with the results of other studies. However, long-term follow-up is required for more accurate assessments.
PENGOLAHAN AIR LIMBAH INDUSTRI KECIL PELAPISAN LOGAM
Authors: Yudo Satmoko , Said Nusa Idaman 
Published: June 2020

Water pollution in Jakarta area, especially river and shallow groundwater, had become a very serious problem. Pollution problem caused by small industrial activities had not been got attetion. Some activities, which often cause water pollution problem, were wastewater from electroplating small industry. This wastewater was one of the most potential pollutant sources, because it contains high concentration of heavy metal pollutant such as Fe, Ni, Zn, Cr, ect. To anticipate its negative effect to the environment and social life, it needs to provide a technical standard plan to manage wastewater treatment plant, especially of electroplating small industries. The purpose of these activities is to do the assessment and application of wastewater treatment technology of electroplating small industry. The target is to get design engineering and pilot plant of wastewater treatment technology for electroplating small industry. Kata kunci : Pencemaran logam berat, Pengolahan limbah cair industri kecil pelapisan logam.
MIKROORGANISME PATOGEN DAN PARASIT DI DALAM AIR LIMBAH DOMESTIK SERTA ALTERNATIF TEKNOLOGI PENGOLAHAN
Authors: Said Nusa Idaman , Marsidi Ruliasih 
Published: June 2020

Domestic waste are known to be a potential pollutant due to its’ organic and inorganic content. It is also harmful for society for its pathogenic microorganism contents such as pathogenic bacteria, viruses, parasitic worms, parasitic protozoa, etc. The lack of domestic waste processing facilities is contributing to the increasing seriousness of this matter.One of the alternative ways to amend the problem is to process the waste individually or semi-communally by utilizing an aerobic-anaerobic biofilter process. Some of the advantage of utilizing this process is: easy maintenance, low operation cost, relatively lower sludge compared to the activated sludge process, can remove nitrogen and phosphorus, relatively lower air supply requirement for aeration, applicable in processing waste water with large amount of BOD and it can also remove suspended solid (SS). Results gained from experiments of the “Aerobic-Anaerobic Biofilter Combination” tool prototype, used for processing domestic waste showed that with a hydraulic retention time of 1 to 3 days and a Hydraulic re-circulation ratio (HRR) of 1, is a highly efficient process which is: BOD 84.7% - 91%, COD 79.6%-95.3%, SS 94.1% - 95%, Ammonia (NH4-N) 89.3%-89.8%, Detergent (MBAS) 83% - 87% and phosphate (PO4) 44,4% - 47.3%. Kata kunci : Air limbah domestik, patogen, parasit, biofilter, anaerob, aerob.
PENGELOLAAN AIR MINUM BERBASIS MASYARAKAT Studi Kasus Pembangunan Air Minum Di Desa Nelayan II Kabupaten Sungai Liat, Propinsi Bangka-Belitung
Authors: Yudo Satmoko 
Published: June 2020

According to the result of the World Bank study, from 121 drinking water management projects in rural area, only 20 (16,6%) are very effective projects. A lot of drinking water management in developing country, including Indonesia is not running well. One of the reasons of this problem is that community did not take part in developing and managing drinking water treatment plant. A right policy and strategy could overcome the problem and give an effective and sustainable of drinking water management.This paper generally explain principles and general policy in developing the drinking water treatment plant and how to apply the strategies, therefore that it is running well and the are will being of the community sustainable.There is also an example, a case study about small-scale drinking water treatment plant in a fisherman village, Sungai Liat, Province Bangka-Belitung where the community took part in every stage of building it. Keywords: Community based of drinking water management, policy of developing the drinking water treatment plant, application of strategies
APLIKASI METODA RES-2D UNTUK EKSPLORASI AIR BAWAH TANAH DI DAERAH KARS
Authors: Kuswanto Agus 
Published: June 2020

People have long been interested in kars, the typically topograhy in limestone area. There are many spectacular ornament in the caves caused by carbonates presipitates. Among the most common shapes which is be chief attraction for cave visitors is stalactites, stalagmites and columns. Beside of the excitements, kars also have hard problem for people who lived in that area. It is how to find out water for their living. Karst formation, both the surface (dolina, hill, etc) and underground forms (caverns, groundwater conduits, underground streams), appears as conductive zones relative to adjacent undisturbed limestone. Therefore resistivity methode will produce good results if applied to identify dolina, conduits , caverns and structure of geology in kars. The methode describes in this paper is Res-2D with configuration of pole-dipole with area for research are kars in Pacitan and Tulungagung region. Four principal layers can typically be differentiated in a vertical section : near surface (clayey) loam and soil in dolina, dry karstified limestone, conduit cave and solid unkarstified limestone. They have contrast of resistivity. Conduits have resistivity value range from 10 to 20 ohmm, whereas resistivty of cave is 1000 ohmm. Karstified limestone have resistivity value from 20 to 250 ohmm, whereas massive limestone have resistivity 250 ohmm. This paper shows that Res-2D methode can give good contribution in exploration of groundwater in kars area. Kata Kunci : Kars, Res-2D, Conduits
KINETIKA PROSES AOPs UNTUK PENGHILANGAN WARNA AIR LIMBAH PRODUKSI BATIK
Authors: Nugroho Rudi , Mahmud Ikbal 
Published: June 2020

An experiment of Advanced Oxydation Processes (AOPs) was conducted in semi-pilot scale using ozon and hydrogen peroxide. The reaction of ozon and hydrogen peroxide produce an active hydroxil which can crack a long-chain organic compounds such as azo dyes. A wastewater contains colour substances coming from batik industries in Jababeka was treated by AOPs. The reaction rate was affected by ozon concentration supplied to the wastewater. The more ozon concentration, the colour removal became faster.The colour removal using AOPs could be illustrated by first-order chemical reaction equation.The constant of reaction was calculated from experiment as high as 0,38 per hour.The cost for treating the wastewater using AOPs was Rp.3.656,- for one cubic meter of wastewater. Key words: AOPs, Colour Removal, Hydrogen Peroxide, Ozon,
PENGELOLAAN DATA SISTEM ALIRAN DRAINASE KOTA Studi Kasus : Jakarta Selatan dan Jakarta Timur
Authors: Indriatmoko Robertus Haryoto , Wahjono Heru Dwi , Yudo Satmoko 
Published: June 2020

Fast growing development at big cities such as Jakarta usually cause surface hydrology problems, which is indicated by many surface detention and local floods during rainy season. These problems were raised because of the increasing of runoff coefficient of sub catchment areas and limited capacity of existing drainages. Analysis have made on drainage capacity of sub catchment areas connected to peak flow cause by rain on certain recurrence period and result in data to evaluate drainage capacity to solve these water detention and local floods problems. Katakunci : Genangan, Banjir, Drainase, DAS, Database.
APLIKASI PROSES BIOFILTRASI DAN ULTRA FILTRASI UNTUK PENGOLAHAN AIR MINUM
Authors: Said Nusa Idaman 
Published: June 2020

To reduce the organic substance and ammonia in raw water hence raw water from river have to be processed by pretreatment prior to main processing unit. One of the alternatives is biological treatment using submerged biofilter which filled with honeycomb plastic supporting media. Research conducted by operating continuous flow biofilter reactor wich filled with honeycomb plastic supporting media. The size of biofilter reactor is 59 cm x 30 cm x 210 cm, with total volume 371.7 litres. The research was conducting by continuous operation under condition 4 hours, 3 hours, 2 hours and 1 hour retention time. The result of experiment shows that within the biofilter process under conditions 4 hours, 3 hours, 2 hours and one hour retention time, the removal efficiency of organic substance were 67.27 %, 53,89 5,45.70 % and 30.92 % respectively. And the removal efficiency of ammonia under conditions 3 hours, 2 hours and one hour retention time were 73.59 %, 67.98 %, and 48.74 % respectively. The longer retention time has resulted in higher removal efficiency. By combining biofiltration process with ultra fltration (UF) membrane technology, hence will be got technological alternative of drinking water process which able to degrade an organic matter and ammonia without chemicals instead of convensional process. Kata Kunci : biofiltasi, membran, ultra filtrasi, air minum.
PELAKSANAAN AMDAL, UKL DAN UPL SERTA IPLC DI DKI JAKARTA
Authors: Said Nusa Idaman 
Published: June 2020

Pelaksanan tentang analisis mengenai dampak lingkungan secara nasional di atur berdasarkan Peraturan Pemerintah Nomor 27 Th 1999 tentang Analisis Mengenai Dampak Lingkungan Hidup (AMDAL). Sejak diberlakukannya Peraturan Pemerintan Nomor 27 tahun 1999 ini dan Undang-Undang Nomor 22 Tahun 1999 tentang Otonomi daerah, sebagian besar penilaian AMDAL dilaksanakan oleh Komisi Penilai Amdal Daerah, sedangkan kegiatan yang bersifat strategis, Lintas Negara dan Propinsi dinilai oieh Komisi Penilai Amdal Pusat (Meneg LH).Dalam rangka pelaksanaan AMDAL di Propinsi DKI Jakarta, Gubernur telah mengeluarkan Keputusan Gubernur Provinsi DKI Jakarta No. 2863 tentang Jenis Rencana Usaha dan/atau Kegiatan Yang Wajib Dilengkapi Dengan AMDAL. Keputusan Gubernur Nomor 2863 Tahun 2001 tersebut mengatur 12 sektor atau bidang yang meliputi :Bidang pertahanan dan Keamanan; Bidang Pertanian; Bidang Perikanan; Bidang Kesehatan; Bidang Perhubungan Darat,Laut,Udara, teleko-munikasi; Bidang Perindustrian; Bidang Prasarana Wilayah; Bidang Energi dan Sumber Daya Mineral yaitu Pertambangan Umum/ Ketenaga Listrikan/Minyak dan Gas Bumi/Geologi Tata lingkungan; Bidang Pariwisata; Bidang Pengembangan Nuklir; Bidang Pengelolaan Limbah Bahan Berbahaya dan Beracun (B3); serta Bidang Rekayasa Genetika.Makalah ini membahas masalah mekanisme pelakasanaan AMDAL, UKL, UPL serta ijin pembuangan limbah cair (IPLC) di Propinsi DKI Jakarta. Kata Kunci : AMDAL, UKL, UPL, IPLC, DKI Jakarta.
RANCANG BANGUN POMPA HIDRAM UNTUK MASYARAKAT PEDESAAN
Authors: Herlambang Arie , Wahjono Heru Dwi 
Published: June 2020

Environmental contamination and global climate change cause degradation of fresh water in the whole world. Increasing of oil price also insist the water treatment operational cost rise, especially for pumping and water lifting from the low land areas to up land. One of alternatif solution to reduce operational cost is using Hydraulic ram pumps (hydram pump). Hydram pump are water-lifting devices that are powered by filling water. Such pumps work by using the energy of water falling a small height to lift a small part of that amount of water to a much greater height. In this way, water from a spring or stream in a valley can be pumped to a village or irrigation scheme on the hillside. The main and unique advantage of hydram pumps is that with a continuous flow of water, a hydram pump operates automatically and continuously with no other external energy source - be it electricity or hydrocarbon fuel. It uses a renewable energy source (stream of water) mid hence ensures low running cost. Minimum up lifting vertical power of pump is twice than vertical distance of water down and maximum up lifting vertical power is twenty times than vertical distance of water down. If there are air captured in distribution pipe, it will need release valve. In this paper, different aspect of designing a hydraulic-rain pump system is discussed. Application and limitation of hydram pump is presented. It imparts absolutely no harm to the environment Hydraulic ram pumps are simple, reliable and require minimal maintenance. All these advantages make hydram pumps suitable to rural community water supply and mud backyard irrigation in developing countries. Kata Kunci : Air bersih pedesaan, pompa hidram, pengelolaan air bersih.
EVALUASI KESEIMBANGAN AIR DI PROVINSI JAWA TENGAH
Authors: Nugroho Sutopo Purwo 
Published: June 2020

Water supply for the domestics use of Central Java Province has been experiencing problems and challenging. With population of 35 million or 16% of Indonesia, it place the province as the third in national population. It have consequently, water need in the province is as such for use of domestics, irrigation/agriculture, industry, etc. Several counties within the province has experiencing water shortage. Particularly during dry season, defisits is inclining that results water use conflicts. Furthermore, conflicts occur not only in counties with water shortage but also in county with sufficient water supply. Conflict is generally triggered by weak management and allocation. This is a result of unlimited territorial sovereighnity of water resources and uncertainty of water rights. Unlimited territorial sovereighnity of water resource contain exclusive right to utilize tap water within the territorial right, in way that the territory hold the sole right to exploit the resource without compensation to neighbouring territory. Hence, water balance should be investigated better and comprehensively. Kata kunci: keseimbangan air, konflik, sumber daya air, Jawa Tengah.
PEMANTAUAN KUALITAS AIR SUMUR MENGGUNAKAN MULTIPROBE SENSOR DIGITAL DI WILAYAH SEKITAR SEMBURAN LUMPUR SIDOARJO
Authors: Wahjono Heru Dwi 
Published: June 2020

Bursts of mud in Sidoarjo has caused changes in environmental quality around the bursts area. Observation in that area indicate there have been changes in air quality and odor caused by mud spurt. In addition, changes in the geological structure of land in the area around the mud spurt, has resulted some water spurt phenomenon that came from the well pump belong to some residensts in that area. This water spurt phenomenon is followed by the change of water quality which was to be used for the needs of daily living, now in some villages in the area around the mud bursts can no longer be used. To find out some parameters of water quality that arises from the some well pumps that produce big water spurt, we need to performed water quality monitoring using multiprobe digital sensors that are able to measure several parameters at once.This paper presents the measurement data of water quality in some well pumps that produce big water spurts with the YSI600R digital sensor. Keywords : Perubahan kualitas lingkungan, semburan lumpur Sidoarjo, pemantuan kualitas air, sumber bubble, sumur pompa, sumur bor, separasi air dan gas, multi probe digital sensor
POTENSI PENCEMARAN DARI LIMBAH CAIR INDUSTRI PENGOLAHAN IKAN DI KECAMATAN MUNCAR, KABUPATEN BANYUWANGI
Authors: Setiyono Setiyono , Yudo Satmoko 
Published: June 2020

Fish processing industries in Muncar-Banyuwangi have increased the welfare of the people there and made this area known as the major fish producer in Indonesia. More than 50% of its production has been exported to many countries and the rest has fulfilled domestic need. Although fish processing industry has developed quickly, its industrial pollution effect hasn’t been handled well so that it polluted the surrounding envionment especially water surface. It happened because of using water for industrial need reached 17.883,2 m3 /day and almost all industries haven’t provided a good wastewater installalion so that the environment couldn’t handle and neutrilize the wastes. This paper explains condition of fish processing industries and potential load of the wastewater produced by them. Keywords : Industri Pengolahan Ikan, Limbah Cair Industri, Pencemaran Lingkungan, Informasi.
KAJIAN ASPEK KEBIJAKAN DAN REGULASI DALAM MASALAH PENGELOLAAN LIMBAH CAIR INDUSTRI RUMAH TANGGA
Authors: Rahardjo Petrus Nugro 
Published: June 2020

Water pollution because of the domestic wastewater produced by the local community and their home industries in a big city, such as Jakarta, has already been inviting many environmental problems since the last ten years. Based on the research done by Directorat General Cipta Karya, Public Works Department RI, domestic wastewater in Jakarta delivers 75% of all pollutants in surface water pollution. Therefore many things should be done to solve those water pollution problems. A lot of environmentally related rules have established in Indonesia, but they are not able to be optimally implemented because of some weaknesses of the environmental rule contents. One of the solving options is to create a perfect regulation system for wastewater management. The laws for home industry wastewater management, especially in big cities, have to be perfectly completed, mainly in the field of standard, operation and procedure, the wastewater quality standard, the adequate and qualified technology, the landscape and building planning and the institutional coordination. If the all environmental regulations are well synchronized, the law enforcement will be simply implemented. By applying them consistently, the water pollution control will be handled well. Keywrods : Environmental Regulation, Home Industry Waste Water, Institutional Coordination