bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sexual Dimorphism in Drug Metabolism and Pharmacokinetics
Authors: Valodara Askhi M. , SR Kaid Johar 
Published: October 2019

Background:Sex and gender-based differences are observed well beyond the sex organs and affect several physiological and biochemical processes involved in the metabolism of drug molecules. It is essential to understand not only the sex and gender-based differences in the metabolism of the drug but also the molecular mechanisms involved in the regulation of drug metabolism for avoiding sex-related adverse effects of drugs in the human.Method:The articles on the sex and gender-based differences in the metabolism of drug molecules were retrieved from the Pub Med database. The articles were classified into the metabolism of the drug molecule, gene expression regulation of drug-metabolizing enzymes, the effect of sex hormones on the metabolism of drug, expression of drugmetabolizing enzymes, etc.Result:Several drug molecules are known, which are metabolized differently in males and females. These differences in metabolism may be due to the genomic and non-genomic action of sex hormones. Several other drug molecules still require further evaluation at the molecular level regarding the sex and gender-based differences in their metabolism. Attention is also required at the effect of signaling cascades associated with the metabolism of drug molecules.Conclusion:Sex and gender-based differences in the metabolism of drugs exist at various levels and it may be due to the genomic and non-genomic action of sex hormones. Detailed understanding of the effect of sex and related condition on the metabolism of drug molecules will help clinicians to determine the effective therapeutic doses of drugs dependingon the condition of patient and disease.
Anti-Tumour Activity of Glycodendrimer Nanoparticles in a Subcutaneous MEC-1 Xenograft Model of Human Chronic Lymphocytic Leukemia
Authors: Ziemba Barbara , Sikorska Hanna , Jander Magdalena , Kuncman Wojciech , Danilewicz Marian , Appelhans Dietmar , Bryszewska Maria , Borowiec Maciej , Franiak-Pietryga Ida 
Published: October 2019

Background:Chronic Lymphocytic Leukaemia (CLL) is an indolent disorder, which mainly affects older adults. Since the advent of chemoimmunotherapy, great progress has been made in its treatment. However, some patients develop a more aggressive form of the disease and are included in the group of high-risk CLL patients with a dismal prognosis and a need for new therapies.Objective:Maltotriose-modified poly(propylene imine) dendrimers were presented as potential agents in targeted therapy for CLL in the murine xenograft model.Methods:Tumour, brain and internal organs resected from NOD scid gamma mice were subjected to gross and histopathological evaluation.Results:The results of ex vivo tissue examination indicated that open-shell glycodendrimers prevented/inhibited the spread of CLL into the brain and internal organs and its transformation into a more aggressive form.Conclusion:The results of the study have a potentially important impact on the design of future personalized therapies as well as clinical trials.
Fascinated Nanofiber Yarns: From Experiment to Industrialization
Authors: Liu Hong-Yan 
Published: October 2019

Background:
Bubble electrospinning patent has been commercially used for the massproduction
of various nanofibers, but its application to the fabrication of nanofiber yarns is less studied.
We assume that there is great potential in this direction.

Objective:
This paper focuses on bubble electrospinning with an emphasis on new technologies for the
fabrication of fascinated nanofiber yarns by the bubble electrospinning.

Methods:
The paper begins with the mechanism of the bubble electrospinning to introduce how it produces
fascinated nanofiber yarns experimentally, then the industrialization of fascinated nanofiber
yarns is illustrated.

Results:
The bubble electrospinning is extremely suitable for the fabrication of fascinated nanofiber
yarns with a hierarchical structure, and the hierarchy can be designed biomimetically according to
some natural fibers.

Conclusion:
This paper sheds light on both experimental study and industrial applications of fascinated
nanofiber yarns.
An Insight on the Association of Psychological Studies, Cognitive Sciences and Meditation in Treating Depression
Authors: Pal Rashmi S. , Saraswat Nikita , Wal Pranay , Wal Ankita , Pal Yogendra , Roohi Tamsheel F. 
Published: October 2019

Background:
Depression is the neuropsychiatric disorder that can lead to the
disruption of brain nerves by elevating different mechanisms and neurotransmitters such as
serotonin, noradrenaline, dopamine. It can have a series of episodic events that can cross
one episodic depression to another and manifest various symptoms such as agitation, melancholia,
deep sadness, psychomotor retardation, mood swings and suicidal deaths.

Objective:
This paper gives information about the various factors such as psychological,
genetic, biological and environmental factors that play a vital role in the pathogenesis of
depression and its associated symptoms. In spite of usage of antidepressant drugs, many
clinicians and physicians follow other therapies and interventions or certain medications
such as psychological studies, cognitive sciences, and meditation and yoga that help in the
ailment of depression.

Method:
The data was collected by studying combination of research and review papers
from different databases like PubMed, Medline, and Web of science by using search keywords
like “depression”, “cognitive sciences”, “meditation”, “yoga”, “psychotherapies”,
“mindfulness activities”, “factors associated with depression and its episodes”.
Result: It was found that besides the use of antidepressants, a considerable number of studies
and researches on therapies exhibit the examined effects of different psychotherapies,
psychological studies, cognitive sciences and yoga-based interventions show potential effects
in the ailments of depression and its associated symptoms.

Result:
It was found that besides the use of antidepressants, a considerable number of studies
and researches on therapies exhibit the examined effects of different psychotherapies,
psychological studies, cognitive sciences and yoga-based interventions show potential effects
in the ailments of depression and its associated symptoms.

Conclusion:
Based on this paper, we have concluded that with the use of psychotherapies
such as interpersonal therapy, problem-solving therapy, MBCT, MBSR, DBT, ACT, yoga
and its different techniques are more effective than other medication therapies.
Gamificación como estrategia pedagógica para los estudiantes de Medicina nativos digitales
Authors: Dorado Martínez Claudia , Chamosa Sandoval María Esther 
Published: October 2019

Introducción: Ante el vertiginoso avance tecnológico, la educación ha tenido que adaptarse al nuevo entorno de los estudiantes, entendidos como nativos digitales. Una de las estrategias que actualmente cobra presencia es la gamificación (estrategias propias de los videojuegos en apoyo al aprendizaje).
Objetivo: Conocer los hábitos de consumo de los alumnos del Curso Propedéutico a fin de evaluar la viabilidad de implementar estrategias de gamificación que favorezcan el aprendizaje de nativos digitales que estudian la Licenciatura de Médico Cirujano en la Universidad Justo Sierra.
Método: El abordaje fue deductivo, con una metodología cuantitativa a través de la aplicación de una encuesta. que tiene acceso a Internet en casa, el resto (46%) utiliza los datos de sus sistemas de telefonía móvil, y 0% recurre a opciones públicas o a sitios de paga como cafés internet. El 25% utiliza Internet menos de 14 horas a la semana, 53% entre 15 y 30 horas, y 22% más de 31 horas a la semana. La población de profesores entrevistada estuvo compuesta por un 60% de mujeres y un 40% de hombres, cuya edad varía de los 35 a los 67 años, y el 45% de la población abordada estaría de acuerdo con capacitarse mediante el asesoramiento de compañeros, otro 45% estaría conforme con actualizarse en el marco de cursos durante los periodos vacacionales; el 9% desearía capacitarse en línea.
Conclusiones: De acuerdo con los resultados obtenidos, es viable dar paso a la experimentación con recursos de gamificación en la Escuela de Medicina de la Universidad Justo Sierra.
Estudio bibliométrico y redes de coautoría del Dr. Manuel Velasco Suárez
Authors: Pérez-Juárez Julio Isahi , Gutiérrez-Aceves Guillermo Axayacalt , Herrera-González José Alfredo , León-Marroquín Elsa Yazmín , Chávez-Ramírez Alejandra , Salinas-Lara Citlaltepetl 
Published: October 2019

Introducción: La cooperación entre investigadores se ha convertido actualmente en el pilar fundamental del progreso de la ciencia.
Objetivo: Nuestro propósito es el análisis del nivel de productividad y colaboración del Dr. Manuel Velasco Suárez como escritor de publicaciones.
Método: Es un estudio bibliométrico retrospectivodescriptivo y examen de redes de coautoría, de toda la colección disponible de artículos del Dr. Manuel Velasco Suárez, indexada en la base de datos PubMed. Los indicadores bibliométricos utilizados son de actividad. Los parámetros y la construcción de redes complejas fueron realizados mediante el software Cytoscape Versión 3.5.0.
Resultados: Tamaño bibliométrico: 66. Índice de productividad: 1.819. Grado de colaboración: 0.378. Una red con 57 nodos y 136 conexiones. Diámetro: 4. Radio: 1. Centralidad: 0.393. Coeficiente de agrupamiento: 0.824. Densidad: 0.085.
Discusión: Los valores matemáticos lo revelan como un gran creador de literatura médica, aunado a un bajo grado de vinculación con otros científicos. La exploración mediante redes señala un pequeño nivel de asociación entre sus elementos.
Conclusiones: El Dr. Velasco publicó decenas de trabajos con los cuales forjó una prolífica vida a favor de la neurocirugía mexicana, no obstante, sus alcances pudieron
llegar a ser más grandes al colaborar con un mayor número de investigadores.
Variables clave para una intervención eficaz en deshonestidad académica
Authors: Río Adhara , Durán Mar , Ferraces María José , Rodríguez Mauro 
Published: October 2019

El objetivo fundamental de este trabajo es explorar la importancia de las emociones, positivas y negativas, y la conducta pasada en la intención de llevar a cabo conductas académicas deshonestas más allá de la explicación dada por la Teoría de la Conducta Planificada. Se utilizó una muestra final de 262 estudiantes de la Universidad de Santiago de Compostela, con edades comprendidas entre los 18 y 26 años. Los resultados mostraron que las variables añadidas aumentan de manera significativa la capacidad explicativa del modelo (ΔR² =22%). Esto, junto con la relación que presentan las variables con la intención conductual [emociones positivas (β=.10), conducta pasada (β=.51)], es lo que hace que estas variables adquieran relevancia explicativa en el modelo y nos dote de herramientas necesarias para intervenir y ayudar a mejorar la formación académica de nuestros jóvenes.
RACISMO E VIOLÊNCIA CONTRA QUILOMBOS NO BRASIL
Authors: Araújo Eduardo , Da Silva Givânia Maria 
Published: October 2019

No ano de 2018 a Coordenação Nacional de Articulação das Comunidades Negras Rurais Quilombolas, a Terra de Direitos, a Associação de Advogados de Trabalhadores Rurais da Bahia e Coletivo Joãozinho do Mangal – Assessoria Jurídica Popular lançaram o relatório Racismo e Violência contra Quilombos no Brasil com a finalidade expor em âmbito nacional e internacional as violações de direitos humanos perpetradas contra quilombolas no Brasil. Além do viés de denúncia, o relatório contribui para compreensão das formas de (re)existências através das mobilizações políticas e jurídicas por direitos. O relatório compila memórias e lutas sociais, jurídicas, políticas e culturais desenvolvidas por lideranças quilombolas e das assessorias jurídicas. A identidade a ancestralidade e as territorialidade compõe uma circularidade de saberes-fazeres que demonstram a atualidade das reivindicações dos quilombos frente à ordem neocolonial, neoliberal e racista da sociedade e do Estado brasileiro. Em 2003 foi promulgado o Decreto 4.887, com a finalidade de regulamentar os direitos constitucionais (Constituição Federal da República Federativa do Brasil de 1988) ao território. O Decreto foi atacado pela frente ruralista em 2004 perante o Supremo Tribunal Federal, o julgamento durou 14 anos. Em 2018 o STF acatou a tese de constitucionalidade defendida pelos quilombolas.
TRONCO RADICULAR E SUA IMPORTÂNCIA NO ESTABELECIMENTO E PROGRESSÃO DA DOENÇA PERIODONTAL. UMA DISCUSSÃO BASEADA EM EVIDÊNCIAS
Authors: Dos Santos Porto Barboza Eliane 
Published: October 2019

RESUMOObjetivo: A lesão de furca é definida como a reabsorção óssea patológica na área anatômica onde as raízes de dentes multirradiculares divergem. Os molares são os dentes mais afetados pela doença periodontal e a maior taxa de mortalidade desses dentes pode ser explicada pela morfologia que favorece o envolvimento de furca. Portanto, o dentista deve conhecer a anatomia da furca para diagnosticar precocemente seu envolvimento e tratar com precisão. O objetivo deste estudo é discutir, embasado em evidências científicas, a importância do tronco radicular no estabelecimento e progressão da doença periodontal. Materiais e métodos: uma revisão da literatura foi realizada na base de dados PubMed utilizando os termos tronco radicular, área de pré-furca, doença periodontal, envolvimento de furca em inglês. Resultados: Quarenta e três estudos foram selecionados e sete estudos foram incluídos nesta revisão. O tronco radicular na superfície lingual é maior do que na vestibular em molares inferiores. A área de pré-furca foi encontrada em todos os molares estudados. Os pré-molares superiores também apresentam área de pré-furca e 37% são bifurcados. A altura do tronco radicular e a concavidade da pré-furca interferem no tratamento. Conclusão: As características morfológicas do tronco radicular e a profundidade e largura da área de pré-furca podem favorecer o estabelecimento e progressão da doença periodontal.Palavras-chave: tronco radicular, área de pré-furca, doença periodontal, envolvimento de furca. ABSTRACTObjective: The furcation lesion is defined as pathological bone resorption in the anatomical area where the roots of multiradicular teeth differ. Molars are the teeth most affected by periodontal disease and the higher mortality rate of these teeth can be explained by the morphology that favors the furcation involvement. In this way, the dentist must know the anatomy of the furca to diagnose its involvement early and to treat with precision. The aim of this study is to discuss, based cientific evidences, the importance of the root trunk for the establishment and development of the periodontal disease. Material and Methods: A literature review was carried out in the PubMed database using the terms root trunk, pre furcation área, periodontal disease, furcation involvement in english. Results: Forty-three studies were selected and sextuplets were found at the time of the review. The root trunk at the lingual surface is larger than the buccal surface in lower molars. A pre-furcation area was found in all molars studied. Upper premolars also have a pre-furcation area and 37% are bifurcated. The height of the root trunk and the concavity of the pre-furcation area interfere in the treatment. Conclusion: Root trunks and concavity of the pre furcation area may favor the stablishment and progression of periodontal disease.Keywords: root trunk, pre furcation área, periodontal disease, furcation involvement.
ATENDIMENTO ODONTOLÓGICO AO PACIENTE PORTADOR DE HEMOFILIA C: QUAIS SÃO CUIDADOS NECESSÁRIOS PARA UM CORRETO ATENDIMENTO? – REVISÃO DE LITERATURA
Authors: Figueiredo de Brito Resende Rodrigo 
Published: October 2019

RESUMOA hemofilia é uma doença hemorrágica hemofilia hereditária ligada ao cromossomo X, caracterizada pela deficiência ou anormalidade da atividade coagulante do fator VIII (hemofilia A), do fator IX (B) ou mesmo do fator XI (hemofilia C). Esta doença é causada pela deficiência quantitativas dos fatores de coagulação, podendo causar sangramento espontâneo ou mesmo induzido por cirurgia ou trauma. A hemofilia C foi descrita em 1953, após vários membros de famílias de descendentes judaica (judeus Ashkenazi, descendentes de judeus que abandonaram Jerusalém e migraram para a Polônia e Báltico durante o primeiro século), terem surgidos com hemorragias excessiva ao serem submetidos a amigdalatomia e exodontias. A deficiência deste fator, é hereditária, resultante de uma mutação em um gene autossômico recessivo presente no cromossomo 4. Embora o diagnostico precoce seja de difícil execução, pois o paciente não apresenta sangramento espontâneo como em outros hemofilia, uma rigorosa anamnese deve ser realizada para que se possa tomar todas as medidas preventivas, evitando possíveis riscos ao paciente. O objetivo deste trabalho é realizar uma revisão de literatura sobre os cuidados necessários que o cirurgião – dentista deve ter frente a um paciente portador de hemofilia C. Para que o mesmo possa indicar e realizar corretamente o tratamento odontológico e evite possíveis riscos. Palavras-chaves: Hemofilia; Hemofilia C; Atendimento odontológico; Fator XI. ABSTRACTHemophilia is a hereditary hemorrhagic disease linked to the X chromosome, characterized by the deficiency or abnormality of factor VIII (hemophilia A), factor IX (hemophilia B) or even factor XI (hemophilia C) factor VIII coagulant activity. This disease is caused by the quantitative deficiency of coagulation factors, which can cause spontaneous bleeding or even induced by surgery or trauma. Haemophilia C was described in 1953 after several members of families of Jewish descent (Ashkenazi Jews, descendants of Jews who left Jerusalem and migrated to Poland and the Baltic during the first century), have arisen with excessive hemorrhages when undergoing tonsilatomy and Exodontia. The deficiency of this factor is hereditary, resulting from a mutation in an autosomal recessive gene present in chromosome 4. Although the early diagnosis is difficult to perform, since the patient does not present spontaneous bleeding as in other haemophilia, a rigorous anamnesis should be performed for That all preventive measures can be taken, avoiding possible risks to the patient. The objective of this work is to carry out a review of the literature on the necessary care that the dental surgeon must have in front of a patient with hemophilia C. In order that he may indicate and correctly perform the dental treatment and avoid possible risks. Key words: Hemophilia; Hemophilia C; Dental care; Fact
Value Relevance of Disaggregated Information: An Examination of the Rate and Volume Analysis of Bank Net Interest Income
Authors: Burke Qing L. , Warfield Terry D. , Wieland Matthew M. 
Published: October 2019

SYNOPSIS
A potentially important form of financial information disaggregation is to segregate the change in an income measure into its underlying performance drivers. In this study, we perform a comprehensive analysis of the usefulness of such disaggregation to investors. We utilize the volume and rate analysis in banks' 10-K filings, in which banks disaggregate annual changes in net interest income into changes in the balances (“volume variance”) and changes in the rates (“rate variance”) of assets and liabilities. We document that volume and rate variances are associated with bank characteristics, including market power, funding sources, and credit risk. We find volume and rate variances are predictive of future net interest income and are positively associated with stock returns and prices, suggesting the disaggregated information is value relevant. Our study informs regulators and users by showing that disaggregated information along volume and rate dimensions has predictive and confirmatory value.
Bauhaus y el desarrollo histórico del diseño gráfico
Authors: Oyarvide-Estupiñan Nataly Samara 
Published: October 2019

La combinación de la academia de Bellas Artes con la Escuela de Artes y Oficios, posterior a la coordinación de Gropius, con la intención de unificar las actividades y eliminar las contradicciones entre artistas y artesanos, permitiendo grandes cambios en el desarrollo histórico del diseño gráfico. Con base en este postulado, este artículo tuvo como objetivo estudiar la escuela de Bauhaus y el desarrollo histórico del diseño gráfico. Para ello se consideró una metodología de tipo hermenéutica y cuyo análisis teórico permitió generar entre sus resultados que existió simultaneidad del desarrollo la escuela de Bauhaus en Alemania, en Francia y otros países europeos optaron por un movimiento distinto. Después de la guerra, el estilo decorativo del modernismo empezó a sustituirse por trazos más simples y rectilíneos, más en armonía con la estética plana y el menor coste de los diseños industriales.
PENGELOLAAN KEUANGAN BERBASIS APLIKASI SISTEM KEUANGAN DESA
Authors: Martini Rita , Agustin Resy , Fairuzdita Amira , Murinda Anggun Noval 
Published: October 2019

Pengalokasian dana membutuhkan pengelolaan keuangan desa yang bersih, tertib, efektif, dan efisien. Sebagai pertanggungjawabannya, desa menyusun laporan keuangan yang dipermudah dengan adanya Aplikasi Sistem Keuangan Desa (SISKEUDES). Dalam penerapannya, perangkat desa mengalami kesulitan dalam pengoperasianya. Kajian ini bertujuan mengetahui penerapan aplikasi SISKEUDES dalam pengelolaan keuangan termasuk kendala-kendala yang terjadi sebenarnya di lapangan. Metode pelaksanaan dilakukan dengan pendampingan dan observasi kemudian dipaparkan secara kualitatif. Hasilnya penerapan aplikasi SISKEUDES mendukung penyediaan laporan keuangan berbasis komputer, namun dalam pelaksanaaannya terkendala oleh kompetensi sumber daya manusia dan fasilitas desa yang kurang memadai. Kata kunci: Pengelolaan keuangan, aplikasi SISKEUDES AbstractThe allocation of village funds requires village finance management that is compassionate, subordinate, effective and efficient. As a responsibility, the village prepares financial reports that are facilitated by the application of the village financial system (SISKEUDES). In its implementation, village officials have difficulties in the operation of this application. The purpose of this article is to find out the application of SISKEUDES in financial management including the actual obstacles that occur in the field. The implementation method is carried out with assistance and observations are then presented qualitatively. The result of the application implementation supports the provision of computer-based financial reports, but in the implementation there some obstacles come from inadequate competence of human resources and village facilities. Keywords: Financial management, SISKEUDES application