bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interconnection between implementation and competitive dimensions of SCM and combined approach (TQM–SCM) in context of Indian manufacturing industry
Authors: Kaur Mandeep , Singh Kanwarpreet , Singh Doordarshi 
Published: May 2020

PurposeThe purpose of this paper is twofold. Firstly to check the reliability between and within the parameters of total quality management–supply chain management (TQM–SCM) questionnaire and distribution of data collected through questionnaire from SCM and combined approach (TQM–SCM) companies. Secondly, to analyze the correlation connection among dependent and independent parameters of both SCM and combined approach in order to check and increase confidence in the data obtained before conducting actual research.Design/methodology/approachIn the present study, 45 Indian manufacturing organizations have been extensively surveyed to check the reliability of the data and then ascertain the inter-relationships between various independent factors and competitive dimensions of SCM alone and for combined approach (TQM–SCM).FindingsFirstly, the data for both the approaches are reliable. Secondly, independent variables (X1–X8) possess more strong correlation with business performance parameters of combined approach (TQM–SCM) companies as compared to only SCM companies.Originality/valueTQM and SCM are considered as performance improvement techniques by the manufacturing organizations. As far as the author knows, this is the first study that is designed to find the interconnection between implementation factors as well as competitive dimensions of SCM approach and TQM–SCM approach in the context of Indian manufacturing organizations.
Culturomics‐based genomics sheds light on the ecology of the new haloarchaeal genus Halosegnis
Authors: Durán‐Viseras Ana , Andrei Adrian‐Ştefan , Vera‐Gargallo Blanca , Ghai Rohit , Sánchez‐Porro Cristina , Ventosa Antonio 
Published: May 2020

SummaryThe development of culture‐independent techniques has revolutionized our understanding of microbial ecology, especially through the illustration of the vast gap between the environmentally abundant microbial diversity and that accessible through cultivation. However, culture‐based approaches are not only crucial for understanding the evolutionary, metabolic and ecological milieu of microbial diversity but also for the development of novel biotechnological applications. In this study, we used a culturomics‐based approach in order to isolate novel microbial taxa from hypersaline environments (i.e. Isla Cristina and Isla Bacuta salterns in Huelva, Spain). We managed to obtain axenic cultures of four haloarchaeal strains that belong to a new haloarchaeal genus and to obtain their genomic sequences. The phylogenomic and phylogenetic analyses (together with AAI, ANI and digital DDH indices) showed that the isolates constitute two new species, for which we propose the names Halosegnis longus sp. nov. and Halosegnis rubeus sp. nov. The genomic‐based metabolic reconstructions indicated that members of this new haloarchaeal genus have photoheterotrophic aerobic lifestyle with a typical salt‐in signature. 16S rRNA gene sequence reads abundance profiles and genomic recruitment analyses revealed that the Halosegnis genus has a worldwide geographical distribution, reaching high abundance (up to 8%) in habitats with intermediate salinities.
Politically Connected Governments
Authors: CUNY CHRISTINE , KIM JUNGBAE , MEHTA MIHIR N. 
Published: May 2020

ABSTRACTThis paper examines the consequences of powerful political connections for local governments. We find that governments located within the constituencies of, and thus connected to, powerful congressional members reduce their stewardship over public resources. Using plausibly exogenous declines in the power of congressional representation, we show that the effect is causal. To better understand why connected local governments can reduce stewardship, we study electoral characteristics. Our findings suggest that the increased resources that come with powerful congressional representation allow local‐government officials to reduce stewardship without material adverse effects on their reelection prospects. In sum, we provide evidence of a cost of political connections: they weaken local governments' incentives to act in a socially optimal manner.
18F‐FDG PET/CT imaging of small intestinal metastasis from pulmonary sarcomatoid carcinoma: Brief report and review of the literature
Authors: Xie Xinli , Tu Ning , Wang Qi , Cheng Zhen , Han Xingmin , Bu Lihong 
Published: May 2020

We herein report two cases of small intestinal metastasis from pulmonary sarcomatoid carcinoma (PSC) detected by 18F‐fluorodeoxyglucose positron emission tomography/computed tomography (18F‐FDG PET/CT). We reviewed the literature on 18F‐FDG PET/CT features in gastrointestinal metastasis of PSC patients since 1992, and further analyzed the imaging features. According to the literature review, 23 eligible cases were identified from eight studies, and no cases underwent 18F‐FDG PET/CT imaging. In this study, clinical and PET/CT imaging data of two patients are reported. In our cases, clinical and the CT images of lung masses were not typical, but the uptake of 18F‐FDG was remarkably high, with SUVmax exceeding 30. Small intestinal metastases may not be related to obstruction, or even the local intestinal cavity may be dilated. Therefore, in PSC patients with mild or without abdominal symptoms, 18F‐FDG PET/CT imaging could identify intestinal metastasis at a relatively early stage and may be used to determine the preferred biopsy site, or early intervention by surgery.Key points18F‐FDG PET/CT imaging of small intestinal metastasis of PSC has not been previously reported in the literature and here we report the 18F‐FDG PET/CT features of two cases.The uptake of 18F‐FDG was remarkably high in both the primary tumor and metastatic intestinal lesion. 18F‐FDG PET/CT imaging may therefore be used to determine the preferred biopsy site or early intervention by surgery.
The efficacy of corticosteroid‐sparing immunomodulatory therapy in treating patients with central multifocal choroiditis
Authors: de Groot Evianne L. , ten Dam‐van Loon Ninette H. , de Boer Joke H. , Ossewaarde‐van Norel Jeannette 
Published: May 2020

AbstractPurposeTo evaluate the efficacy of corticosteroid‐sparing immunomodulatory therapy (IMT) in patients with recurrent and/or sight‐threatening central multifocal choroiditis (MFC).MethodsThis was a retrospective cohort study in a tertiary uveitis centre including all patients with MFC who have been treated with IMT for at least 12 months. Clinical data and imaging results were collected regarding the period prior to the start of IMT and at 3, 6, 12 and – where available – 24 months after the start of IMT. Main outcome measure was the number of annual recurrences of choroiditis with or without active choroidal neovascularization before and after the start of IMT. Secondary outcomes were the percentage of patients with (steroid‐free) remission and the median time between the start of IMT and (steroid‐free) remission.ResultsThirty‐two patients (39 eyes) were included. At the start of IMT, none of the patients were in (steroid‐free) remission. At 24 months, the probability of achieving remission and steroid‐free remission was 88,5% and 50%, respectively. The median time to achieve remission and steroid‐free remission was 21 and 83 weeks, respectively. In 17 patients (20 eyes) with available clinical data and imaging results for ≥ 12 months prior to the start of IMT, the mean number of recurrences/year decreased significantly from 1.40 ± 0.81 at baseline to 0.49 ± 0.47 (p = 0.001) after the start of IMT.ConclusionsPreventive therapy with IMT should be considered in patients with recurrent and/or sight‐threatening MFC to decrease the number of recurrences/year and to increase the prospects of achieving either remission or steroid‐free remission.
Long‐term results of the MCL01 phase II trial of rituximab plus HyperCVAD alternating with high‐dose cytarabine and methotrexate for the initial treatment of patients with mantle cell lymphoma
Authors: Massaro Fulvio , Stepanishyna Yana , Manni Martina , Luminari Stefano , Galimberti Sara , Marcheselli Luigi , Visco Carlo , Tecchio Cristina , Stelitano Caterina , Angrilli Francesco , Petrini Mario , Merli Francesco , Federico Massimo 
Published: May 2020

SummaryMantle cell lymphoma is a rare and incurable lymphoproliferative disorder. In the MCL01 trial, patients were treated with the R‐HCVAD regimen [rituximab plus HyperCVAD (hyperfractionated cyclophosphamide, vincristine, doxorubicin, dexamethasone; R‐CVAD) alternating with high‐dose methotrexate and cytarabine (AM)] for four cycles followed by autologous stem cell transplantation (ASCT) for those who reached only a partial response. After a median follow‐up of 10·5 years, we reported 10‐year progression‐free and overall survival rates of 35% and 61% respectively, with a 10‐years cumulative incidence rate of second malignancies of 10·6%. Mature results of the MCL01 trial confirmed the efficacy of HyperCVAD‐AM as a frontline regimen for younger patients (≤65 years).
Environmental change interventions to prevent unintentional home injuries among children in low‐ and middle‐income countries: A systematic review and meta‐analysis
Authors: Bhatta Santosh , Mytton Julie , Deave Toity 
Published: May 2020

AbstractIntroductionUnintentional home injury is an important cause of death and disability among children, especially those living in low‐ and middle‐income countries (LMICs). This systematic review aimed to synthesize evidence about the effectiveness of environmental interventions to prevent unintentional child injury and/or reduce injury hazards in the home in LMICs.MethodsSeven electronic databases were searched for randomized controlled trials (RCTs) and controlled before and after (CBA) studies published up to 1 April 2018. Potentially eligible citations were screened by title and abstract and full texts of studies obtained. Synthesis was reported narratively, and where possible, meta‐analysis was conducted.ResultsFour studies met the inclusion criteria: One CBA study reported changes in injury incidence, and three RCTs reported changes in frequency of home hazards. In one study, child resistant containers were found effective in reducing the incidence of paraffin ingestion by 47% during and by 50% postintervention. A meta‐analysis of two trials found that home inspection, safety education and safety devices reduced postintervention mean scores for poisoning hazards [mean difference (MD) −0.77; 95% CI [−1.36, −0.19]] and burn‐related unsafe practices (MD −0.37; 95% CI [−0.66, −0.09]) but not for falls or electrical and paraffin burn hazards. A single trial found that home inspection and safety education reduced the postintervention mean scores for fall hazards (MD −0.5; 95% CI [−0.66, −0.33]) but not for ingestion hazards.ConclusionThere is limited evidence that environmental change interventions reduce child injuries but evidence that they reduce some home hazards. More evidence is needed to determine if altering the physical home environment by removing potential hazards reduces injuries in LMICs.
Loss and vulnerability of lowland forests in mainland Southeast Asia
Authors: Namkhan Maliwan , Gale George A. , Savini Tommaso , Tantipisanuh Naruemon 
Published: May 2020

AbstractDespite containing extraordinary levels of biodiversity, lowland (<200 m asl) tropical forests are extremely threatened globally. Southeast Asia is an area of high species richness and endemicity under considerable anthropogenic threat with, unfortunately, scant focus on its lowland forests. We estimated extent of lowland forest loss from 1998 to 2018, including inside protected areas and determined the vulnerability of this remaining forest. Maximum likelihood classification techniques were used to classify Landsat images to estimate lowland forest cover in 1998 and 2018. We used Bayesian belief networks with 20 variables to evaluate vulnerability of the forest that remained in 2018. Analyses were conducted at two spatial scales: landscape patch (analogous to ecoregion) and country level. Over 20 years, >120,000 km2 of forest (50% of forest present in 1998) was lost. Of the 14 lowland forest patches, 6 lost >50% of their area. At the country scale, Cambodia had the greatest deforestation (>47,500 km2). In 2018, 18% of the lowlands were forested, and 20% of these forests had some formal protection. Approximately 50% of the lowland forest inside protected areas (c. 11,000 km2) was also lost during the study period. Most lowland forest remaining is highly vulnerable; eight landscape patches had >50% categorized as such. Our results add to a growing body of evidence that the presence of protected areas alone will not prevent further deforestation. We suggest that more collaborative conservation strategies with local communities that accommodate conservation concessions specifically for lowland forests are urgently needed to prevent further destruction of these valuable habitats.
Evaluation and impact assessment of culture‐based fisheries to enhance fish yield in small reservoirs in Odisha State, India
Authors: Sarkar Uttam K. , Lianthuamluaia Lianthuamluaia , Panda Debabrata , Kumari Suman , Parida Pranaya K. , Karnatak Gunjan , Mishal Puthiyottil 
Published: May 2020

AbstractThe present study investigates the success of stocking fingerlings of Indian major carps ‐Gibelion catla (Hamilton), Labeo rohita Hamilton and Cirrhinus mrigala Hamilton – to enhance fish yield in 58 small reservoirs in Odisha State, India. Fish stocking and yield data were collected from State Fisheries Department, Odisha. The relationships between area, stocking density and fish yield of different size groups of reservoirs were assessed using the Pearson correlation coefficient (r). Fish yield increased significantly (p < 0.05, t‐test) from 204 kg/ha/year in 2012–13 to 323 kg/ha/year in 2013–14 due to adoption of CBF. The corresponding per capita fish production increased from 398 kg fisher−1 year−1 to 702 kg fisher−1 year−1 benefitting more than 8,000 fisher households. Reservoirs in the size group 100–500 ha showed the highest response of fish yield with respect to stocking of fingerlings. The size of fingerlings at stocking and area of the reservoir had greater impact on enhancing fish yield. Stocking had a profound positive impact on fish yield. This study forms a baseline evaluation of the impact of stocking on small tropical reservoirs in India. It also recommends management measures and discusses issues, and the way forward for sustainable fisheries enhancement in small tropical reservoirs in eastern India.
miR‐126 reduces trastuzumab resistance by targeting PIK3R2 and regulating AKT/mTOR pathway in breast cancer cells
Authors: Fu Rao , Tong Jing‐Shan 
Published: May 2020

AbstractMicroRNAs (miRNAs) have been found to play a key role in drug resistance. In the current study, we aimed to explore the potential role of miR‐126 in trastuzumab resistance in breast cancer cells. We found that the trastuzumab‐resistant cell lines SKBR3/TR and BT474/TR had low expression of miR‐126 and increased ability to migrate and invade. The resistance, invasion and mobilization abilities of the cells resistant to trastuzumab were reduced by ectopic expression of miR‐126 mimics. In comparison, inhibition of miR‐126 in SKBR3 parental cells had the opposite effect of an increased resistance to trastuzumab as well as invasion and migration. It was also found that miR‐126 directly targets PIK3R2 in breast cancer cells. PIK3R2‐knockdown cells showed decreased resistance to trastuzumab, while overexpression of PIK3R2 increased trastuzumab resistance. In addition, our finding showed that overexpression of miR‐126 reduced resistance to trastuzumab in the trastuzumab‐resistant cells and that inhibition of the PIK3R2/PI3K/AKT/mTOR signalling pathway was involved in this effect. SKBR3/TR cells also showed increased sensitivity to trastuzumab mediated by miR‐126 in vivo. In conclusion, the above findings demonstrated that overexpression of miR‐126 or down‐regulation of its target gene may be a potential approach to overcome trastuzumab resistance in breast cancer cells.
Vital root resection in severely furcation‐involved maxillary molars: Outcomes after up to 7 years
Authors: Jepsen Karin , Dommisch Eva , Jepsen Søren , Dommisch Henrik 
Published: May 2020

AbstractAimsTo introduce a novel therapeutic approach for the treatment of furcation‐involved maxillary molars by vital root resection and report longer‐term outcomes of a case series.MethodsEleven patients with 15 maxillary molars affected by double/triple class II (n = 10) or single/double class III (n = 5) furcation defects and advanced vertical bone loss around one root participated. Teeth were treated with deep pulpotomy using a calcium silicate‐based cement. After 4 weeks, the affected roots were removed by periodontal microsurgery and processed for histological evaluation of the pulp. All patients were enrolled into a supportive periodontal care programme. During the follow‐up period, assessments of tooth sensitivity, response to percussion, mobility, pocket probing depth (PPD) and bleeding on probing (BOP) were made, periapical radiographs obtained and patient‐reported outcomes collected.ResultsAll teeth remained sensitive to pulp testing. After 1 year and 3–7 years of follow‐up, PD was ≤5 mm at all resected teeth. Furcation status was much improved. Neither increasing mobility nor clinical or radiographic signs of periapical pathology were observed throughout the individual observation period. All patients were pleased with the result of therapy. Histologic sections revealed a functional dentin‐pulp complex.ConclusionsThis case series demonstrates the possibility of maintaining severely furcation‐involved molars by vital root resection for up to 7 years. Root canal therapy and its associated costs and complications can thus be avoided.
Evaluation of the levels of secretory leukocyte protease inhibitor in the cervical mucus of women with unexplained infertility
Authors: Madendag Ilknur Col , Sahin Mefkure Eraslan , Madendag Yusuf , Sahin Erdem , Karakukcu Cigdem 
Published: May 2020

AbstractAimSecretory leukocyte protease inhibitor (SLPI) has specific effects on the immune system. SLPI is overexpressed in inflammation triggered by immune responses, which could have significant effects on the local immune responses in cervical mucosa. This over expression may be greater in women with unexplained infertility, which would increase the immune reaction in the cervical region against sperm. The aim of our study was to assess the levels of SLPI in cervical mucus in women with unexplained infertility.MethodsThis prospective cross‐sectional study was conducted using 50 Caucasian volunteers between 20 and 40 years old. The 50 participants were divided into two groups as unexplained infertility (n = 20) and control (n = 30). The control group comprised healthy fertile women with demographic characteristics similar to those of the infertility group. The enzyme‐linked immunosorbent assay method was used to assess SLPI levels in the cervical mucus of all participants.ResultsThe median SLPI level in cervical mucus was 3767 (3541–4594, 95% CI) pg/mL (25th percentile; 3139 pg/mL, 75th percentile; 5047 pg/mL) in the unexplained‐infertility group and 3204 (2602–3539, 95% CI) pg/mL (the 25th percentile = 2615 pg/mL; 75th percentile = 3990 pg/mL) in the control group, which was a significant difference (P = 0.013).ConclusionOur results indicated that SLPI levels in cervical mucus were remarkably higher in patients with unexplained infertility than in the control group.
Trends in the use of medications with insomnia side effects and the implications for insomnia among US adults
Authors: Do Duy 
Published: May 2020

AbstractAmericans are increasingly consuming pharmaceuticals that although effective in treating their focal indication, include insomnia as a side effect. Regardless, no studies have documented trends in the concurrent use of these medications and their implications for insomnia among community‐dwelling adults. Using a nationally representative sample of US adults from the 1999–2016 National Health and Nutrition Examination Survey (NHANES), this study shows that the concurrent use of medications with insomnia as a potential side effect (“insomnia side effects” hereafter) has increased considerably in the past two decades. Between 1999 and 2016, the use of one and two or more medications with insomnia side effects increased by 66% and 164%, respectively. Compared to non‐users, respondents who took two or more of these medications were more likely to report insomnia symptoms (odds ratio [OR] = 1.78; 95% confidence interval [CI], 1.22 to 2.60), daytime sleepiness symptoms (OR = 1.73; 95% CI, 1.16 to 2.60) and difficulty with at least two daytime activities due to sleepiness or tiredness (OR = 1.96; 95% CI, 1.28 to 3.00). These findings highlight the need for insomnia screenings among patients who consume medications with insomnia side effects. They also emphasize the increased risks of insomnia associated with polypharmacy.
Objectively measured sedentary time, physical activity and liver enzyme elevations in US Hispanics/Latinos
Authors: Li Jun , Hua Simin , Chen Guo‐Chong , Strizich Garrett , Kuniholm Mark H. , Shan Zhilei , Talavera Gregory A. , Castañeda Sheila F. , Gellman Marc D. , Cai Jianwen , Cotler Scott J. , Zhang Xuehong , Hu Frank B. , Kaplan Robert , Isasi Carmen R. , Qi Qibin 
Published: May 2020

AbstractBackground & AimsSedentariness and physical inactiveness are associated with deleterious health outcomes, but their associations with liver enzyme elevations remain uncertain.MethodsIn 10 385 US Hispanics/Latinos from the Hispanic Community Health Study/Study of Latinos, we examined associations of sedentary time and moderate‐to‐vigorous physical activity (MVPA) measured by accelerometers with liver enzyme elevations. Elevated alanine aminotransferase (ALT), aspartate aminotransferase and γ‐glutamyltransferase (GGT) were defined as the highest gender‐specific deciles. Prevalence ratios (PRs) and 95% confidence intervals (CIs) were calculated using weighted Poisson regressions.ResultsAfter adjusting for demographical/socioeconomic factors and MVPA, increasing quartiles of sedentary time were associated with a higher prevalence of elevated ALT (PRs [95% CI] = 1.0, 1.17 [0.92‐1.47], 1.21 [0.96, 1.53] and 1.51 [1.13‐2.02]; P‐trend = .007) and elevated GGT (PRs [95% CI] = 1.0, 1.06 [0.82‐1.36], 1.35 [1.06‐1.73] and 1.66 [1.27‐2.16]; P‐trend = .0001). These associations were attenuated but remained significant after further adjustment for cardiometabolic traits including body‐mass index, waist‐hip‐ratio, lipids and homeostatic model assessment of insulin resistance. In contrast, increasing quartiles of MVPA were associated with a lower prevalence of elevated ALT (PRs [95% CI] =1.0, 0.97 [0.77‐1.23], 0.84 [0.66‐1.06] and 0.72 [0.54‐0.96]; P‐trend = .01) after adjusting for demographical/socioeconomic factors and sedentary time, but this association became non‐significant after further adjustment for cardiometabolic traits. Notably, the association of sedentary time with GGT elevation was significant both in individuals meeting the US Physical Activity Guidelines for Americans (MVPA ≥150 minutes/week) and in those who did not (both P‐trend ≤ .003).ConclusionsOur findings suggest that objectively measured sedentary time is independently associated with elevated ALT and GGT in US Hispanics/Latinos.