bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase II study of avelumab plus intermittent axitinib in previously untreated patients with metastatic renal cell carcinoma (Tide-A study).
Authors: Iacovelli Roberto , Atzori Francesco , Basso Umberto , Bersanelli Melissa , Bonomi Lucia , Bracarda Sergio , Buttigliero Consuelo , Fantinel Emanuela , Calabro Fabio , Chiuri Vincenzo Emanuele , Di Lorenzo Giuseppe , Fornarini Giuseppe , Massari Francesco , Naglieri Emanuele , Ortega Cinzia , Procopio Giuseppe , Milella Michele , Santoni Matteo , Vitale Maria Giuseppa , Zucali Paolo Andrea 
Published: February 2020

TPS762 Background: The combination of avelumab plus axitinib has been recently reported to be superior than sunitinib alone for treatment of previously untreated mRCC patients (Motzer, NEJM 2019). The study reported a median PFS of 13.8 for the combination of avelumab plus axitinib compared to 8.4 months for sunitinib (p<0.001) with an ORR of 48% vs 24%, respectively. To improve treatment efficacy and safety, TKI discontinuation has been considered in patients treated with sunitinib leading to a longer definitive progression free survival (22.4 months) and overall survival (34.8 months) with a better safety profile (Ornstein, JCO 2017). Despite a new tumor response at TKI reintroduction, many patients progressed after the first months of treatment discontinuation suggesting the necessity to maintain the previous response. This study aims to test if patients achieving a tumor response with the combination of avelumab plus axitinib, can discontinue the TKI in order to delay the resistance and decrease the toxicity related to the combination of therapies. Methods: The single arm, phase II TIDE-A trial, aims to evaluate the activity of avelumab as maintenance therapy in patients with mRCC who achieved a tumor response after the induction phase of therapy with the combination of avelumab and axitinib. Eligible patients have clear cell carcinoma, ECOG performance status 0 or 1, measurable, no bulky disease without tumor-related symptoms or hepatic metastases. Eligible patient will receive the combination of avelumab plus axitinib for 36 weeks. Patients achieving RECIST 1.1 partial response discontinue the axitinib and continue avelumab. At tumor progression, the axitinib will be restarted for at least six months. If a new tumor response is achieved, axitinib will be discontinued again until tumor progression. Patients with RECIST 1.1 stable disease continue the combination of avelumab and axitinib until progression of disease. The primary endpoint is to evaluate the rate of patients free of progression after 8 weeks from axitinib discontinuation. The study is currently ongoing in twenty centres in Italy.
Cancer Mortality Patterns in Tanzania: A Retrospective Hospital-Based Study, 2006-2015
Authors: Lyimo Emanuel P. , Rumisha Susan F. , Mremi Irene R. , Mangu Chacha D. , Kishamawe Coleman , Chiduo Mercy G. , Matemba Lucas E. , Bwana Veneranda M. , Massawe Isolide S. , Mboera Leonard E.G. 
Published: February 2020

PURPOSE This retrospective study sought to determine the type, burden, and pattern of cancer deaths in public hospitals in Tanzania from 2006 to 2015. METHODS This study analyzed data on cancer mortality in 39 hospitals in Tanzania. Data on the age and sex of the deceased and type of cancer were extracted from hospital death registers and report forms. Cancer types were grouped according to the 10th revision of the International Classification of Diseases. Age-standardized mortality rates and cancer mortality patterns were analyzed. A χ2 test was used to examine the association between common cancers and selected covariates. RESULTS A total of 12,621 cancer-related deaths occurred during the 10-year period, which translates to an age-standardized hospital-based mortality rate of 47.8 per 100,000 population. Overall, the number of deaths was notably higher (56.5%) among individuals in the 15- to 59-year-old age category and disproportionately higher among females than males ( P = .0017). Cancers of the cervix, esophagus, and liver were the 3 major causes of death across all study hospitals in Tanzania. Cancers of the cervix, esophagus, and liver were the largest contributors to mortality burden among females. Among males, cancers of the esophagus, liver, and prostate were the leading cause of mortality. CONCLUSION There is an increasing trend in cancer mortality over recent years in Tanzania, which differs with respect to age, sex, and geographic zones. These findings provide a basis for additional studies to ascertain incidence rates and survival probabilities, and highlight the need to strengthen awareness campaigns for early detection, access to care, and improved diagnostic capabilities.
Double beta decay without invoking closure
Authors: Pantis G. , Vergados J. D. 
Published: February 2020

The nuclear matrix elements of PU operators entering in the 0v ßß-decay of 76Ge-->76Se have been calculated explicitly in the context of QRPA within the model space 0f7/2 - 0h11/2. T h e validity of the closure approximation has been tested and seems to be quite satisfactory for those matrix elements which are not usually suppressed. Our results indicate that they are dominated by multipoles other than 0+ and 1+ and that the matrix elements are comparable to those of shell model calculations.
Cerebral palsy with dislocated hip and scoliosis: What to deal with first?
Authors: Helenius Ilkka J. , Viehweger Elke , Castelein Rene M. 
Published: February 2020

Purpose Hip dislocation and scoliosis are common in children with cerebral palsy (CP). Hip dislocation develops in 15% and 20% of children with CP, mainly between three and six years of age and especially in the spastic and dyskinetic subtypes. The risk of scoliosis increases with age and increasing disability as expressed by the Gross Motor Function Score. Methods A hip surveillance programme and early surgical treatment have been shown to reduce the hip dislocation, but it remains unclear if a similar programme could reduce the need for neuromuscular scoliosis. When hip dislocation and neuromuscular scoliosis are co-existent, there appears to be no clear guidelines as to which of these deformities should be addressed first: hip or spine. Results Hip dislocation or windswept deformity may cause pelvic obliquity and initiate scoliosis, while neuromuscular scoliosis itself leads to pelvic obliquity and may increase the risk of hip dislocation especially on the high side. It remains unclear if treating imminent hip dislocation can prevent development of scoliosis and vice versa, but they may present at the same time for surgery. Current expert opinion suggests that when hip dislocation and scoliosis present at the same time, scoliosis associated pelvic obliquity should be corrected before hip reconstruction. If the patient is not presenting with pelvic obliquity the more symptomatic condition should be addressed first. Conclusion Early identification of hip displacement and neuromuscular scoliosis appears to be important for better surgical outcomes.
Spine deformities in patients with cerebral palsy; the role of the pelvis
Authors: Hasler Carol , Brunner Reinald , Grundshtein Alon , Ovadia Dror 
Published: February 2020

Introduction Progressive neuromuscular spinal deformities with pelvic obliquity and loss of sitting balance are typical features of severely affected patients with cerebral palsy. The pelvis represents the key bone between the spine and the lower extremity when it comes to deciding whether and when to operate and if spine or hip surgery first is beneficial. The pelvis can be looked at as the lowest vertebra and as the rooftop of the lower extremities. Biomechanical considerations To allow for a normal spinal shape, the pelvis needs to be horizontal in the frontal plane and mildly anterior tilted in the sagittal plane, less for sitting and more for standing. Any abnormal pelvic position requires spinal compensation and challenges the equilibrium control of the individual. Both anatomical neighbourhoods – the spine and the hip joints — have to be considered when spinal deformities, hip instability and contractures evolve, in conservative therapy (bracing, physiotherapy, seating in the wheelchair) and when surgical interventions are weighed out against each other. Surgical considerations Multiple anatomical factors such as sagittal profile and pelvic orientiation, pelvic transverse plane asymmetries and lumbosacral malformations have to be considered in case the pelvis is instrumented with sacral and iliac screws. Rotational deformities and asymmetries of the pelvic bones make the safe insertion of long screws challenging. Advantages of primary pelvic fixation include correction of pelvic obliquity, especially considering the lever arm of the whole spinal construct. The risk of revision surgery due to progression of distal curves is also reduced. Disadvantages of pelvic fixation include the complexity of the additional intervention, which may result in longer operating times, increased risk of blood loss, infection and hardware malpositioning.
Mid-infrared chalcogenide microfiber knot resonators
Authors: Xie Yu , Cai Dawei , Wu Hao , Pan Jing , Zhou Ning , Xin Chenguang , Yu Shaoliang , Wang Pan , Jiang Xiaoshun , Qiu Jianrong , Guo Xin , Tong Limin 
Published: February 2020

A novel type of mid-IR microresonator, the chalcogenide glass (ChG) microfiber knot resonator (MKR), is demonstrated, showing easy fabrication, fiber-compatible features, resonance tunability, and high robustness. ChG microfibers with typical diameters around 3 μm are taper-drawn from

As

2

S

3

glass fibers and assembled into MKRs in liquid without surface damage. The measured

Q

factor of a typical 824 μm diameter ChG MKR is about

2.84
×

10

4

at the wavelength of 4469.14 nm. The free spectral range (FSR) of the MKR can be tuned from 2.0 nm (28.4 GHz) to 9.6 nm (135.9 GHz) by tightening the knot structure in liquid. Benefitting from the high thermal expansion coefficient of

As

2

S

3

glass, the MKR exhibits a thermal tuning rate of

110

pm
·
°

C

−
1

at the resonance peak. When embedded in polymethyl methacrylate (PMMA) film, a 551 μm diameter MKR retains a

Q

factor of

1.1
×

10
4

. The ChG MKRs demonstrated here are highly promising for resonator-based optical technologies and applications in the mid-IR spectral range.
Heterologous expression of a plant WRKY protein confers multiple stress tolerance in E. coli Bir bitkinin heterolog ifadesi WRKY proteini çoklu stres yaratır E. coli’de tolerans
Authors: Deeba Farah , Sultana Tasawar , Majeed Nadia , Naqvi Syed Muhammad Saqlan 
Published: February 2020

Abstract

Objective

OsWRKY71, a WRKY protein from rice, is reported to function during biotic stresses. It is requisite to further enquire the efficiency and mechanism of OsWRKY71 under various environmental stresses. Stress indicators such as salt, cold, heat, and drought were studied by overexpressing the OsWRKY71 in E. coli.

Materials and methods
DNA binding domain containing region of OsWRKY71 was cloned and expressed in E. coli followed by exposure to stress conditions. OsWRKY71 was also assessed for its role in abiotic stresses in rice by qPCR.

Results
Recombinant E. coli expressing OsWRKY71 was more tolerant to stresses such as heat, salt and drought in spot assay. The tolerance was further confirmed by monitoring the bacterial growth in liquid culture assay demonstrating that it encourages the E. coli growth under salt, drought, and heat stresses. This tolerance may be the consequence of OsWRKY71 interaction with the promoter of stress related genes or with other proteins in bacteria. The RT-qPCR analysis revealed the up-regulation of OsWRKY71 gene in rice upon interaction to cold, salt, drought and wounding with maximum up-regulation against salinity.

Conclusion
Thus, the defensive role of OsWRKY71 may accord to the development and survival of plants during different environmental stresses.
Educação com diversidade, sociedade com sustentabilidade
Authors: Cavalcante Ludmila Oliveira Holanda 
Published: February 2020

RESUMO: O texto é uma expressão das reflexões realizadas a partir do convite para realizar uma palestra no IX Encontro Científico e Cultural (ENCCULT) em Maceió em agosto de 2019. O tema “Educação com diversidade, sociedade com sustentabilidade” foi dividido em duas partes, a primeira na provocativa questão da Educação para a Diversidade, levando em conta a nossa realidade desafiadora. A segunda parte, transita na perspectiva da constatação de que dentro deste cenário desafiador, a sustentabilidade torna-se uma meta de difícil alcance. Ao final do texto, questiono ser a sustentabilidade um sonho pouco possível neste universo enviesado de mercantilização da política e da educação hegemonizadora, a ela atrelada, mas falando de esperança, defendo ser a perspectiva transgressora da cultura e da educação um caminho possível mediante as estratégias de comunicação com o mundo do outro. Para encontrar as possibilidades de fortalecimentos de contra hegemonia, temos as pistas possíveis: na ciência socialmente referenciada, na educação de responsabilidade social, na cultura de reconhecimento da diversidade, nas organizações e lutas coletivas e ... na consolidação da democracia.
PALAVRAS-CHAVE: Educação, Diversidade, Sustentabilidade.
Tumor de celulas esteroideas: reporte de un caso y revisión de la literatura
Authors: Ramírez Javier Andrés , Suescún Óscar , Palomino María Cristina 
Published: February 2020

Introducción: el tumor de células esteroideas sin otra especificación es una neoplasia poco frecuente de los cordones sexuales del ovario, caracterizada por presentarse en cualquier edad y producir diferentes manifestacionesendocrinasporel influjohormonal de las pacientes que lo padecen. Su potencial de malignidad es de 50%.Objetivo: informar el caso de una paciente de 50 años a la cual se le diagnosticó un tumor de células esteroideas sin otra especificación de comportamiento maligno por medio de un estudio histológico y de inmunohistoquímica. Asimismo, se pretende revisar la literatura disponible respecto a la presentación clínica, la genética, el diagnóstico y el tratamiento de este tipo de neoplasia.Metodología: se realizó una búsqueda electrónica en las bases de datos MEDLINE, Embase, HINARI, Ovid, SciELO y BIREME, a partir de la cual se incluyeron artículos de investigaciones originales y artículos de revisión publicados entre 1987 y 2008.Resultados: se encontraron 74 reportes de casos, para los cuales las manifestaciones clínicas eran variables e inespecíficas dadas según la producción de hormonas tales como la testosterona, los estrógenos o los progestágenos. Las pacientes también podían presentar dolor abdominal, ascitis severa, y síndrome de Cushing. De otro lado, el diagnóstico diferencial incluyó otros tumores esteroideos como: tecomas, luteinizantes, luteomas del embarazo, carcinoma primario de células claras, metastásico de células renales, tumores de células de Leydig y sus subtipos hiliares y no hiliares. Ante esto, el tratamiento requerido debió ser quirúrgico con tratamiento hormonal adyuvante con agonistas de receptores de la hormona liberadora de gonadotropina (GnRH).Conclusión: el tumor de células esteroideas es infrecuente y está asociado con síndromes endocrinos. El manejo no se ha estandarizado y debe individualizarse según la histología tumoral, el estadio quirúrgico y el deseo de fertilidad de la mujer. Asimismo, se requieren estudios para avanzar en el conocimiento de estos tumores.
Procesos participativos como base para el contenido y desarrollo de la aplicación móvil de realidad aumentada: Amón_RA, Costa Rica
Authors: Bulgarelli Bolaños Jose Pablo , Valverde Solano María Del Carmen 
Published: February 2020

Este artículo aborda el tema de la participación de actores clave vinculados al proyecto de investigación Amón_RA: Implementación de la realidad aumentada como herramienta para la puesta en valor y difusión del paisaje urbano histórico de barrio Amón, en San José, Costa Rica. El producto del proyecto será una aplicación móvil, con la que el visitante de barrio Amón pueda obtener, en tiempo real, información sobre las diferentes capas del paisaje urbano histórico que le rodea, permitiéndole generar un criterio del valor natural, histórico, cultural y social de este sector urbano. La entidad financiadora del proyecto fue la Vicerrectoría de Investigación y Extensión del Instituto Tecnológico de Costa Rica (TEC).
El artículo responde a la pregunta, cómo los procesos participativos pueden ser un medio tanto para validar como descubrir información de un barrio y la estratificación de sus diferentes componentes urbanos a través del tiempo, con el propósito de plasmar los datos en contenido para una aplicación móvil de realidad aumentada. El tipo de investigación es cualitativa, con un enfoque constructivista donde las personas relacionadas con barrio Amón participaron como fuente primaria de información, lo que le permitió al equipo investigador descubrir datos cualitativamente significativos para poner en valor el paisaje urbano histórico.
Los procesos participativos brindaron el medio para un mayor entendimiento de los significados y experiencias de las personas que habitan o permanecen en el barrio; así como para validar la información encontrada en fuentes formales. Como principal conclusión es que por el valor de la información cualitativa de parte de los agentes sociales, tales como vivencias, anécdotas y secretos como parte del contenido en la aplicación móvil, esta toma un aspecto más cercano para los usuarios. Los procesos participativos en torno a la aplicación fueron un medio para reunir y documentar información no formal que pertenece a la intimidad de las familias vecinas, que se encuentran en un momento histórico donde buscan perpetuar la memoria e identidad de barrio Amón.
Special Issue on Wearable Robotics and Mechatronics Technology
Authors: Tanaka Takayuki , Kurita Yuichi , Shima Keisuke , Miki Norihisa 
Published: February 2020

Many wearable devices have been developed and are being currently used, owing to the miniaturization of computers and electronic devices and advancements in calculation processing algorithms. They have various uses and forms, for example, a power assist robot for reducing the burden of work, a wearable sensor for measuring the level of activity and health condition of people and animals, and so on. In Japan, wearable devices have attracted attention as an important technology in a human-centered society (Society 5.0) and can help realize economic development and address social problems. A society that can benefit from a wide range of wearable devices is being realized. This special issue covers robotics and mechatronics technologies for next generation wearable devices to realize such a society, including wearable systems and their elemental technology, AI, IoT, and other relative technologies.
We sincerely thank the authors for their fine contributions and the reviewers for their generous time and effort. We would also like to thank the Editorial Board of the Journal of Robotics and Mechatronics for their help with this special issue.
En el edificio de cartón, Habitaciones: la poética «original» de Ricardo Sumalavia
Authors: Valero Juan Eva 
Published: February 2020

Este artículo propone un acercamiento a la primera obra de Ricardo Sumalavia, Habitaciones (1993), desde el punto de vista de la construcción de una nueva visión literaria enraizada en la ciudad, en la serie de relatos que la componen. Inserta en la diversa tradición de la literatura urbana del Perú en el siglo XX, la obra de Sumalavia crea un nuevo planteamiento a través del fragmento y de la historia mínima que transcurre en la ciudad real e imaginada, ya no para referenciar los cambios o el mapa social al modo de sus antecesores más directos, sino para, desde la ciudad, profundizar en comportamientos humanos que son universales. A partir de nuevos mecanismos de la ambigüedad, y del misterio inserto en la realidad cotidiana, se observan los vínculos entre los personajes que, aun protagonizando «habitaciones» en apariencia inconexas, forman un edificio singular, renovador del panorama de la literatura peruana de las últimas décadas.
Robust Procedure for Measuring Particle Size Distribution of Non-Aqueous Drilling Fluids Using Laser Diffraction
Authors: Yuan Hongji , Klasner Scott , Growcock Frederick , Perez Greg 
Published: February 2020

Abstract
Since particle size distribution (PSD) affects drilling fluid performance, devices for measuring particle size have been widely used in the field and in laboratories. Laser diffraction (also called laser light scattering) is the technique most often employed, because it is easy, rapid, and provides reproducible results. However, variations in laser diffraction instrumentation and operating protocols in different testing facilities/laboratories can cause the PSD results to vary significantly. The problem is serious for water-based drilling fluids, but it can be even more severe for non-aqueous drilling fluids (NADFs) because of variations in base fluid and the presence of emulsified water. To address this, a work group was formed by the American Petroleum Institute (API) to develop a general and robust testing procedure for measuring PSD of NADFs using laser diffraction instruments. After identifying fundamental variables (including sampling method, instrument, sonication treatment, dispersant) that can affect PSD results, pilot testing was carried out with various instruments to determine general operating settings regardless of the specific instrument. Based on these studies, a measurement procedure was developed and evaluated with a round robin test in which five NADFs possessing different base fluids, solids content, and water/oil ratios were measured by several laboratories using different particle sizers. The PSD results of these five fluids measured by different laboratories agreed well, confirming the robustness of the measurement procedure. The developed measurement procedure has been accepted and will be included as a recommended procedure in the API RP 13I 2019 revision. This paper will discuss the development of the procedure and the round robin test results in detail.