bluuebunny/crossref_metadata_2025_split huggingface dataset:
MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations
Authors: Rath Sneha , Sharma Rohit , Gupta Rahul , Ast Tslil , Chan Connie , Durham Timothy J , Goodman Russell P , Grabarek Zenon , Haas Mary E , Hung Wendy H W , Joshi Pallavi R , Jourdain Alexis A , Kim Sharon H , Kotrys Anna V , Lam Stephanie S , McCoy Jason G , Meisel Joshua D , Miranda Maria , Panda Apekshya , Patgiri Anupam , Rogers Robert , Sadre Shayan , Shah Hardik , Skinner Owen S , To Tsz-Leung , Walker Melissa A , Wang Hong , Ward Patrick S , Wengrod Jordan , Yuan Chen-Ching , Calvo Sarah E , Mootha Vamsi K 
Published: October 2020

Abstract
The mammalian mitochondrial proteome is under dual genomic control, with 99% of proteins encoded by the nuclear genome and 13 originating from the mitochondrial DNA (mtDNA). We previously developed MitoCarta, a catalogue of over 1000 genes encoding the mammalian mitochondrial proteome. This catalogue was compiled using a Bayesian integration of multiple sequence features and experimental datasets, notably protein mass spectrometry of mitochondria isolated from fourteen murine tissues. Here, we introduce MitoCarta3.0. Beginning with the MitoCarta2.0 inventory, we performed manual review to remove 100 genes and introduce 78 additional genes, arriving at an updated inventory of 1136 human genes. We now include manually curated annotations of sub-mitochondrial localization (matrix, inner membrane, intermembrane space, outer membrane) as well as assignment to 149 hierarchical ‘MitoPathways’ spanning seven broad functional categories relevant to mitochondria. MitoCarta3.0, including sub-mitochondrial localization and MitoPathway annotations, is freely available at http://www.broadinstitute.org/mitocarta and should serve as a continued community resource for mitochondrial biology and medicine.
Characters from the deciduous dentition and its interest for phylogenetic reconstruction in Hippopotamoidea (Cetartiodactyla: Mammalia)
Authors: Gomes Rodrigues Helder , Lihoreau Fabrice , Orliac Maëva , Boisserie Jean-Renaud 
Published: October 2020

AbstractTeeth are frequently used in phylogeny in order to better characterize the evolution of extinct mammal species. While most studies have focused on the adult dentition, the consideration of characters from the deciduous dentition could also contribute to reinforce phylogenetic assumptions or disentangle phylogenetic issues. We chose to investigate the characters of the deciduous dentition in cetartiodactyl taxa in relation to the disputed relationships within hippopotamoids, especially the position of Hippopotamidae. We describe the deciduous dentition of 51 species, among a dataset of 70 cetartiodactyls. We noticed that second and third deciduous premolars have a much lower degree of molarization, and are more suitable for coding than fourth deciduous premolars. Thirty-nine resulting characters were thus added to a previously published matrix, and parsimony and maximum-likelihood analyses were performed. Both analyses provided a better resolved topology for most taxa than without these characters, and with better support for most nodes in the parsimony analysis. Moreover, this analysis provides additional characters supporting the hypothesis of an emergence of hippopotamids within bothriodontine anthracotheres from the Palaeogene of Africa. The promising use of characters from the deciduous dentition in phylogeny should allow discussion of the underlying ontogenetic mechanisms at the origin of dental homology.
Benefits of Family Mealtime Across the Growing Years: A Conceptual Model
Authors: Martin-Biggers Jennifer T , Berhaupt-Glickstein Amanda , Worobey John , Byrd-Bredbenner Carol 
Published: October 2020

Aspects of the home environment, including family meals, are an understudied, yet critical factor in child health outcomes. A comprehensive literature review, based on the IOM's L.E.A.D. framework (Locate, Evaluate, and Assemble evidence to inform Decisions) was conducted to identify links between family meals (frequency and atmosphere) and health, development, and BMI outcomes and to use these findings to create a conceptual model expressing these links. Key search terms were family, meals, dinner, child(ren), youth, parent(s). A search of PubMed, CINAHL and PsycINFO yielded 68 articles. Evidence demonstrates that across the growing years, greater family meal frequency is associated with increased intake of dietary components related to improved health (i.e., fruits, vegetables, fiber, calcium‐rich foods, vitamins) and decreased intake of components experts recommend consuming in limited amounts (i.e., soft drinks). Increased family meal frequency was inversely related to negative health outcomes, such as depressive symptoms and disturbed eating behaviors. Evidence linking frequency of family meals to obesity risk is not conclusive, however youth in families that served family meals frequently tended to have lower BMIs. The conceptual model created in this study may be used by health promotion and nutrition professionals to visually convey to parents the value of family meals.Grant Funding Source: United States Department of Agriculture, National Institute of Food and Agriculture, Grant Number 2011‐68001‐30170
Allis Clamp for Cervical Stabilization During Intrauterine Device Insertion: Time for a Change [6G]
Authors: Newbern Kayce , Rone Bryan 
Published: October 2020

INTRODUCTION:
Intrauterine devices (IUDs) are a common choice for contraception. A cervical stabilization device is recommended to provide cervical traction and to reduce the uterocervical angle. The device instructions recommend using a single tooth tenaculum. A tenaculum is a traumatic clamp which causes bleeding at the clamp site. We hypothesized that use of an atraumatic Allis clamp would require less hemostatic interventions.

METHODS:
The study was a randomized control trial of 95 IUD insertions. The physicians were randomized to use the Allis clamp or a tenaculum for cervical stabilization. The primary outcome was cervical site bleeding after clamp removal. Other outcomes were the number of interventions required for hemostasis and success of IUD placement. Statistical analyses were performed using the Fisher exact test and Chi-squared test.

RESULTS:
Bleeding was present after clamp removal in 3 (6.3%) insertions using an Allis clamp and 26 (55.3%) insertions using a single tooth tenaculum, P<.0001. Bleeding was absent in 45 (93.8%) insertions using an Allis clamp and 21 (44.7%) insertions using a single tooth tenaculum, P<.0001. There was no difference in the number of interventions required for hemostasis when bleeding occurred after clamp removal. There was no difference in IUD insertion success rates between the two clamps.

CONCLUSION:
The Allis clamp can be successfully used in place of a single tooth tenaculum for cervical stabilization during IUD insertion. The Allis clamp is associated with less bleeding and less need for hemostatic interventions after clamp removal. The Allis clamp is a better device for cervical stabilization during IUD insertion.
Prevalence of Sexual Dysfunctions and Orientations on Sexuality in Postpartum Women: Cross-Sectional Study [4T]
Authors: Guendler Julianna , Katz Leila , Flamini Maria Eduarda , Lemos Andrea , Amorim Melania 
Published: October 2020

INTRODUCTION:
Sexual education by health professionals during the postpartum period is extremely important in maintaining healthy sexual activity. In this context, the study proposed to identify the prevalence of sexual dysfunction in postpartum women and health professionals' orientations on sexual function after childbirth.

METHODS:
A descriptive, cross-sectional study, including 100 women up to one year postpartum, aged 18 years or more and sexually active, excluding pregnant women. Two questionnaires were applied, one for sample characterization and to evaluate orientations on sexuality and the Female Sexual Function Index (FSFI). An exploratory descriptive analysis was performed using SPSS for Windows. The study was approved by Ethics Committee and all women signed a consent form.

RESULTS:
The mean age of the sample was 26 years (SD 6.2), 45% were brown, 62% were married/stable union, 47% had completed high school and 67% were housewives. Almost half of the women (48%) received orientations on when to return sexual intercourse in the postpartum period, however, none of them received any other orientation about postpartum sexuality. The mean number of days for returning intercourse after delivery was 55.6 (SD 24.8). The prevalence of sexual dysfunction was 55%, using a score lower than 26.55 for classification of sexual dysfunction with the FSFI questionnaire.

CONCLUSION:
More than half of women were classified as having sexual dysfunction and none of them received guidance on postpartum sexual function. These findings serve as an alert to the importance of encouraging health professionals to guide the aspects of sexuality to women during prenatal and postpartum periods.
Postpartum Long-Acting Reversible Contraception Is Associated With a Decrease in Recurrent Preterm Birth [3R]
Authors: Toscano Marika A. , Heyrana Katrina , Chen Michael Y. , Whaley Natalie S. , Olson-Chen Courtney 
Published: October 2020

INTRODUCTION:
A history of preterm birth is a major risk factor for subsequent preterm birth. The purpose of this study was to compare the rate of recurrent preterm birth in women who received postpartum long-acting reversible contraception (LARC) to those who did not receive postpartum LARC.

METHODS:
This is a retrospective cohort study of women with singleton gestations who delivered prior to 37 weeks between January 2011 and January 2015. The study was approved by the local IRB, and protected health information was de-identified. The rate of recurrent preterm birth was compared between women who received a LARC method within 12 weeks postpartum and those who did not receive LARC. Chi square analysis and multivariate logistic regression were performed controlling for maternal age, BMI, education, employment, race, ethnicity and insurance type. Interpregnancy interval was investigated as a secondary outcome.

RESULTS:
Of 355 subjects with preterm birth, 110 (31%) received postpartum LARC. The rate of recurrent preterm birth was 10.6% in the LARC group vs 23.4% in the non-LARC group (P=.006). After adjusting for potential confounders, subjects with postpartum LARC were 58% less likely to have a recurrent preterm birth as compared to subjects without postpartum LARC (adjusted 95% CI 0.20 - 0.86). The mean interpregnancy interval was 11.2 months longer in the LARC group as compared to the non-LARC group (P=.003).

CONCLUSION:
LARC placement within 12 weeks following a preterm birth is associated with a decreased risk of recurrent preterm birth. Contraceptive counseling in women with preterm birth should address this risk-reducing intervention.
Perceptions of MFM Trainees and Program Directors Regarding D&E Termination Training [9P]
Authors: Zahedi-Spung Leilah D. , Carter Ebony , Macones George Andrew , Stout Molly Jean 
Published: October 2020

INTRODUCTION:
A 2012 study of Maternal Fetal Medicine (MFM) providers found that only 31% of respondents performed dilation and evacuation (D&E) pregnancy terminations, predominantly based on whether the provider was trained in D&E procedures. The aim of this study is to better understand perceptions of MFM fellows and Program Directors (PD) regarding D&E termination training in MFM fellowship.

METHODS:
We performed an anonymous survey distributed by email in September 2018 to all current MFM Fellows enrolled in ACGME approved MFM fellowships and a separate survey for all current PDs of those fellowships. Surveys included demographic questions including year of residency completion, year of fellowship, current practice of D&Es, and perceptions on fellow D&E training. Descriptive statistics were used to examine practice patterns and perceptions about D&E training.

RESULTS:
The survey response rate for PDs was 46.4% (39/84) and Fellows 62.5% (90/144). Fellow respondents were 83.3% female. 91.1% completed residency in 2016-2018. 82.2% reported D&E training in residency. PD respondents were 56.4% female. 67.5% completed their residency before 2000 (27.0% prior to 1990 and 40.5% from 1991-2000). 64.1% reported D&E training in residency. The majority of Fellows (73.3%) responded that MFM physicians should perform D&E terminations compared to 55.3% of PDs. Almost half of Fellows (48.9%) desire D&E training in fellowship, however, only 23.1% of PDs believe D&E training should be required.

CONCLUSION:
There is a discrepancy between MFM Fellow desires for D&E training and PD opinions on training in MFM Fellowship. Whether D&E training resides in the skillset of MFM physicians should be addressed.
Current Concepts in the Diagnosis and Management of Lymphedema
Authors: Oropallo Alisha , Donis-Garcia Miriam , Ahn Soyouen , Rao Amit 
Published: October 2020

ABSTRACT
Lymphedema is a condition characterized by localized protein-rich swelling caused by damaged or malfunctioning lymphatics. Patients with lymphedema have an increased risk of infection because of the lymphostatic nature of the disease. Chronic ulceration of the skin can make individuals vulnerable to infection leading to serious, sometimes fatal, complications. Proper diagnosis and treatment modalities can aid in the prevention of these complications and ensure better outcomes for the patient.

GENERAL PURPOSE
To present a comprehensive review of lymphedema, including its pathophysiology, assessment, diagnosis, and treatment.

TARGET AUDIENCE
This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care.

LEARNING OBJECTIVES/OUTCOMES
After participating in this educational activity, the participant will:
1. Summarize the etiology, pathophysiology, and clinical manifestations of lymphedema.
2. Describe the diagnostic and treatment approaches for patients who have lymphedema.
Advances in anesthesia education: increasing access and collaboration in medical education, from E-learning to telesimulation
Authors: Nelsen Brenna R. , Chen Yun-Yun K. , Lasic Morana , Bader Angela M. , Arriaga Alexander F. 
Published: October 2020

Purpose of review
The landscape of medical education continues to evolve. Educators and learners must stay informed on current medical literature, in addition to focusing efforts on current educational trends and evidence-based methods. The present review summarizes recent advancements in anesthesiology education, specifically highlighting trends in e-learning and telesimulation, and identifies possible future directions for the field.

Recent findings
Websites and online platforms continue to be a primary source of educational content; top websites are more likely to utilize standardized editorial processes. Podcasts and videocasts are important tools desired by learners for asynchronous education. Social media has been utilized to enhance the reach and visibility of journal articles, and less often as a primary educational venue; its efficacy in comparison with other e-learning platforms has not been adequately evaluated. Telesimulation can effectively disseminate practical techniques and clinical knowledge sharing, extending the capabilities of simulation beyond previous restrictions in geography, space, and available expertise.

Summary
E-learning has changed the way anesthesiology learners acquire knowledge, expanding content and curricula available and promoting international collaboration. More work should be done to expand the principles of accessible and collaborative education to psychomotor and cognitive learning via telesimulation.
Cannabis-related Hospitalizations Among Youth in Canada Before and After Cannabis Legalization
Authors: Auger Nathalie , Luu Thuy Mai , Ayoub Aimina , Bilodeau-Bertrand Marianne , Lo Ernest , Low Nancy 
Published: October 2020

Objectives:
We investigated trends in cannabis-related hospitalizations among youth before and after legalization of recreational cannabis in Canada on October 17, 2018.

Methods:
We computed rates of cannabis-related hospitalizations and the proportion of substance-related hospitalizations involving cannabis by age and sex in the months before and after legalization in Quebec, Canada.

Results:
In boys aged 10 to 14 years, cannabis-related hospitalization rates increased from 5.2 per 100,000 one year before legalization [95% confidence interval (CI) 2.9–9.3] to 9.5 per 100,000 after legalization (95% CI 6.2–14.6), although the increase was not statistically significant. Cannabis was reported in 39.3% of substance-related hospitalizations in boys aged 10 to 14 years before legalization, compared with 70.0% after legalization, representing a difference of 30.7% (95% CI 2.8–58.6). There was no increase in cannabis-related hospitalizations among girls or boys aged 15 to 19 years.

Conclusions:
This study suggests that cannabis legalization in Canada did not increase the risk of short-term cannabis-related hospitalization among girls and older boys. However, legalization may have contributed to an increase in the risk in boys under 15 years. Further data are needed to clarify trends after legalization for younger adolescents.
Electroencephalographic Alpha and Delta Oscillation Dynamics in Response to Increasing Doses of Propofol
Authors: Gutiérrez Rodrigo , Maldonado Felipe , Egaña Jose I. , Penna Antonello 
Published: October 2020

Background:
The electroencephalogram (EEG) may be useful for monitoring anesthetic depth and avoiding overdose. We aimed to characterize EEG-recorded brain oscillations during increasing depth of anesthesia in a real-life surgical scenario. We hypothesized that alpha power and coherency will diminish as propofol dose increases between loss of consciousness (LOC) and an EEG burst suppression (BS) pattern.

Methods:
This nonrandomized dose-response clinical trial with concurrent control included EEG monitoring in 16 patients receiving slowly increasing doses of propofol. We assessed 3 intraoperative EEG segments (LOC, middle-dose, and BS) with spectral analysis.

Results:
Alpha band power diminished with each step increase in propofol dose. Average alpha power and average delta power during the BS step (−1.4±3.8 and 6.2±3.1 dB, respectively) were significantly lower than during the LOC step (2.8±2.6; P=0.004 and 10.1±5.2 dB; P=0.03, respectively). Peak alpha power was significantly higher during the LOC (5.4±2.6 dB) compared with middle-dose (2.6±3.6; P=0.04) and BS (0.7±3.2; P=0.0002) steps. In addition, as propofol dose increased, alpha band coherence between the F7 and F8 electrodes decreased, whereas delta band coherence exhibited a biphasic response (initial increase between LOC and middle-dose steps and decrease between middle-dose and BS steps).

Conclusion:
We report compelling data regarding EEG patterns associated with increases in propofol dose. This information may more accurately define “therapeutic windows” for anesthesia and provide insights into brain dynamics that are sequentially affected by increased anesthetic doses.
Utility of a Computer-assisted Rod Bending System to Avoid Pull-out and Loosening of Percutaneous Pedicle Screws
Authors: Ohba Tetsuro , Ebata Shigeto , Oda Kotaro , Tanaka Nobuki , Haro Hirotaka 
Published: October 2020

Study Design:
This was a retrospective observational study of a cohort of consecutive patients.

Objective:
To compare the influence of (1) manual and (2) computer-assisted (CA) rod bending techniques on pedicle screw pull-out resulting in loosening during rod reduction and final tightening.

Summary of Background Data:
Our recent study showed screw pull-out during rod reduction might be a risk factor for loosening of percutaneous pedicle screws (PPSs) postoperatively, resulting in worse postoperative back pain. We retrospectively analyzed data from 53 consecutive patients who underwent minimally invasive lumbar or thoracic spinal stabilization using intraoperative computed tomography image (CT)-guided navigation with conventional manual rod bending or CA rod bending and were followed up for 1 year.

Method:
Screw pull-out length was measured on axial CT images obtained immediately after screw insertion and postoperatively. Loosening of screws and clinical outcome were evaluated radiographically, clinically, and by CT 1 year after surgery. The frequencies of screw pull-out and screw loosening between the 2 rod bending techniques were compared. Lumbar pain-related factors for both groups of patients were determined preoperatively and 1 year after surgery.

Results:
Overall, 360 pedicle screws were placed in the manual group and 124 pedicle screws were placed in the CA group. There was no significant difference in the mean age, sex, bone mineral density, mean stabilized length, or smoking habits of patients between the groups. The diameters, lengths, and trajectory angle (axial and sagittal) of the screws placed were not significantly different between the groups. Screw pull-out rate/length and loosening in the CA group was significantly lower than that in the manual group. Postoperative low back pain improved significantly in the CA group compared with that in the manual group.

Conclusion:
CA bending is useful to avoid PPS pull-out during rod reduction and screw loosening postoperatively. CA bending is useful to avoid PPS pull-out during rod reduction and screw loosening postoperatively. This result might have been a factor leading to reduced postoperative back pain in the CA group, however, that future studies are need to investigate this association.