bluuebunny/crossref_metadata_2025_split huggingface dataset:
ALSÓVÉGTAG-AMPUTÁLT CUKORBETEGEK A REZILIENCIA TÜKRÉBEN
Authors: MAKAI GÁBOR , BANDI SZABOLCS , KISS ENIKŐ CSILLA 
Published: July 2020

Háttér és célokAz amputáció egy olyan átélt trauma, amely gyökeresen átalakítja az egyén önmagáról és a külvilágról alkotott képét. Jelen vizsgálat célja az volt, hogy megvizsgáljuk, az amputáción átesett betegek milyen pszichés, szociális és fizikai nehézségekkel találják szembe magukat a műtétet követően, valamint hogyan igyekeznek megküzdeni a kritikus élethelyzettel. A reziliencia nézőpontjából azt kerestük, melyek azok a protektív és rizikótényezők, amelyek szerepet játszanak az alkalmazkodóképesség és a betegek mentális egészségének megőrzésében.MódszerAlsóvégtag-amputált diabetes mellitusban szenvedő betegeket (n = 46) vizsgáltunk utánkövetéssel az amputációt követő első, illetve hatodik hónapban, a kutatócsoportunk által összeállított kérdőívcsomag segítségével. Kontrollcsoportként egészséges vizsgálati személyeket vontunk be (n = 63), valamint 2-es típusú cukorbetegeket (n = 54). A kérdőívcsomag tartalmazta a Beck Depresszió Kérdőívet (BDI-R), a Connor–Davidson Reziliencia Skálát (CD-RISC), a Társas Támogatás Kérdőívet (MOS-SSS), a Pozitív és Negatív Affektivitás Skálát (PANAS), valamint a Folkman és Lazarus-féle Konfl iktusmegoldó Kérdőívet (WOC).EredményekAz amputációt követő hatodik hónapban a depresszió, valamint a negatív érzelmek mértéke szignifikáns csökkenést mutat, de a depresszió és a negatív érzelmek jelenléte az alkalmazkodás sikerességét veszélyezteti. Ezzel együtt a reziliencia és a pozitív érzelmek dominanciája növekszik. A társas támogatás keresése, különösképpen a betegek pozitív szociális interakción alapuló támasz iránti igénye nő az idő előrehaladtával, mindez pozitív kapcsolatban áll a rezilienciával. Továbbá protektív tényezőként van jelen a céltudatos cselekvés és az alkalmazkodás mint megküzdési stratégiák, de a negatív érzelmek jelenléte gyengíti a betegek adaptív megküzdését.KövetkeztetésekA magasabb rezilienciával rendelkező betegek alkalmazkodása sikeresebb, mint azoké, akik negatív alkalmazkodási stratégiákat alkalmaznak.
Tepotinib Efficacy in a Patient with Non-Small Cell Lung Cancer with Brain Metastasis Harboring an HLA-DRB1-MET Gene Fusion
Authors: Blanc-Durand Félix , Alameddine Raafat , Iafrate Anthony J. , Tran-Thanh Danh , Lo Ying-Chun , Blais Normand , Routy Bertrand , Tehfé Mustapha , Leduc Charles , Romeo Phillipe , Stephenson Phillipe , Florescu Marie 
Published: July 2020

Abstract

Alterations in c-MET, a tyrosine kinase receptor encoded by the MET gene, have been reported in approximately 3% of non-small cell lung cancer (NSCLC) cases and carry important treatment implications. The best studied genetic alterations are exon 14 skipping and gene amplification; however, gene rearrangement has also been described, and multiple fusion partners have been reported. Recently, in METex14-mutated NSCLC, multitarget tyrosine kinase inhibitors (TKIs), such as crizotinib and cabozantinib, as well as MET-selective TKIs, such as tepotinib and capmatinib, have demonstrated durable responses. In this study, we present the case of a 41-year-old woman with advanced NSCLC harboring an HLA-DRB1-MET gene fusion. The patient was offered successively two different MET multikinase inhibitors, crizotinib and cabozantinib, and the selective inhibitor tepotinib. Each time, including under tepotinib, the patient experienced rapid and complete responses associated with a tremendous improvement in her physical function.

Key Points
To our knowledge, this is the first report of a patient with non-small cell lung cancer harboring an HLA-DRB1-MET gene fusion demonstrating a clinical response to multiple MET inhibitors, including tepotinib. This finding illustrates the efficacy and rationale to targeting MET regardless of fusion partner and gives insight to pooling of patients with different MET fusion products in trials assessing safety and efficacy of novel molecules.
Endometrial expression of e-cadherin in relation to estrogen-progesterone receptor characteristics of the endometrium
Authors: Aganezov S. S. , Ellinidi V. N. , Morotskaya A. V. , Artemyeva A. S. , Nyuganen A. O. , Aganezova N. V. 
Published: July 2020

Aim: to evaluate the endometrial expression of e-cadherin in relation to the estrogen-progesterone-receptor status of the endometrium.Materials and methods. In total 137 women were examined including 81 patients with infertility and 40 with a history of early pregnancy loss (main group); for comparison, 16 healthy fertile women (control group) were also examined. Endometrial aspiration biopsy was performed on 6–8 days after ovulation; in parallel, a peripheral blood sample was taken to determine the levels of estradiol and progesterone. A histological and immunohistochemical study of the endometrium with determination of estrogen (ER) and progesterone (PR) receptors and e-cadherin expression was carried out.Results. All fertile women (n = 16) and only 44 % (n = 53) of patients in the main group had the normal pattern of hormonereceptor endometrial interactions, i. e., low expression of ER and PR in the endometrial glands as well as reduced expression of ER and high expression of PR in the endometrial stroma. The endometrial e-cadherin expression was assessed in the following cohorts: a) women with normal hormone-receptor interactions (16 women in the control group and 53 women in the main group); b) with abnormal variants of hormone-receptor interactions in the endometrium (68 patients in the main group). The frequency of reduced e-cadherin expression was significantly lower in the cohort of women with normal estrogenprogesterone-receptor endometrial status (a) than in the cohort of women with abnormal variants of the endometrial “response” (b): in the luminal epithelium – in 5 % (3 out of 63) (а) vs. 17 % (8 out of 47) (b) (p < 0.05); in the glands – in 13 % (9 out of 69) (a) vs. 37 % (25 out of 68) (b) (p < 0.05).Conclusion. The estrogen-progesterone-receptor status of the endometrium is significant for the e-cadherin expression in the luminal epithelium and glands of the endometrium.
Gestational complications of the prothrombin G20210A mutation related to prothrombin activity
Authors: Nikolaeva M. G. , Yasafova N. N. , Momot A. P. , Zainulina M. S. , Momot K. A. , Taranenko I. A. 
Published: July 2020

Aim: to study the association between prothrombin activity in the blood plasma and gestational complications in women with the prothrombin G20210A mutation.Materials and methods. A prospective clinical cohort study including 290 pregnant women aged 18 to 45 years was conducted from 2012 to 2018. Two cohorts were formed: a study group of 140 patients with the GA genotype and a control group of 150 women with the GG genotype. In the groups, the activity of prothrombin (Factor II) in the venous blood plasma was evaluated during pregnancy. The stages of cytotrophoblast invasion were taken into account when relating the prothrombin activity to gestational complications.Results. The median prothrombin activity in the control group ranged from 108 % during the preconception period to 144 % during pregnancy (95 % CI = 130–150). In the study group with the GA genotype, the activity was significantly higher at the same periods: from 149 to 181 % (95 % CI = 142–195; p < 0.0001). With the prothrombin activity from 148.5 to 180.6 %, the pregnancy in the study group progressed normally. Higher levels of prothrombin activity were associated with early and/or severe preeclampsia (PE), and fetal growth retardation (FGR).Conclusion. The obtained data on prothrombin activity in the blood plasma during pregnancy complications suggest that the manifestation of the GA genotype in the form of early and/or severe PE and FGR is associated with the level of plasma prothrombin activity. The threshold value of Factor II activity was calculated for patients with the G20210A mutation; based on this value it becomes possible to predict PE at the preconception stage (171.0 %; AUC – 0.86; p < 0.0001) and at a gestational age of 7–8 weeks (181.3 %; AUC – 0.84; p < 0.0001).
Psycho-emotional profile of patients with vulvar lichen sclerosus
Authors: Solopova A. G. , Achkasov E. E. , Makatsariya A. D. , Moskvichyova V. S. , Ivanov A. E. 
Published: July 2020

Aim: to assess the psycho-emotional profile in patients with vulvar lichen sclerosus.Materials and methods. We examined 57 patients with a diagnosis of vulvar lichen sclerosus, the average age of 35.0 ± 0.6 (from 18 to 45) years. The control group included 45 healthy women without dystrophic changes in the external genital organs, who applied for a routine examination. The following methods were used to analyze the psycho-emotional profile: WAM questionnaire (well-being, activity, mood), Hospital Anxiety and Depression Scale (HADS), the Dermatology Life Quality Index (DLQI).Results. In patients with vulvar lichen sclerosus a decrease in indicators “well-being” (24.3 ± 1.7 versus 52.4 ± 5.6 scores) and “mood” (28.7 ± 3.6 versus 58.1 ± 6.1 scores) was revealed; “activity” was changed slightly (41.2 ± 3.2 against 47.4 ± 4.9 scores). Depressive (75.4 % versus 15.6 %) and anxiety (68.4 % versus 20 %) disorders were also more common in this group. Significant deterioration in the quality of life in patients was confirmed by a DIQL (18.79 ± 4.98 scores).Conclusion. Psycho-emotional profile of patients with vulvar lichen sclerosus is characterized by a change in most of the analyzed parameters. The presence of anxiety-depressive disorders can aggravate both the general somatic state and the course of the underlying disease. So activities aimed at improving the quality of life should be included in the rehabilitation of these patients.
Side 3, Side 2: The Beatles in Jhumpa Lahiri'sThe Namesake
Authors: Hamelman Steven 
Published: July 2020

ABSTRACTJhumpa Lahiri'sThe Namesakepivots on her Indian‐American protagonist's divided identity. Gogol Ganguli is caught between two cultures, one of which, the Bengali one, he rejects, partly because his parents named him after the Russian author Nikolai Gogol. Lahiri draws upon the Beatles, about whom Gogol is “passionate,” using the “White Album” andAbbey Roadas reference points for Gogol's conflicted identity and for the cycle of love and loss he hears expressed in their music.
“We Know the Way”: Culture–Nature Relationship and Kuleana in Disney's Moana
Authors: Miyose Colby Y. 
Published: July 2020

ABSTRACTOn the Thanksgiving weekend of November 23, 2016, while families were celebrating one cultural tradition, another cultural cornerstone was making waves across the big screen. Moana (meaning wide expanse of water in Hawaiian) has splashed into the hearts of young children, as Disney's latest princess adaptation. Though a sparse amount of recent literature has evaluated the portrayal of Moana‘s tough‐girl femininity, fewer have analyzed representations of Pacific culture. When evaluating cultural values within the movie, Moana encapsulates a nature–culture dualism that many Pacific Islanders (i.e., Hawai'i, Samoa, Tahiti) have adopted as their way of life. For many years, these islands have been favored destinations for vacationers and adventurers as well as colonizers and usurpers, who venture there because of their beautiful landscapes and strategic placement. However, there is another side of these islands that many do not see and even fewer understand. The following paper analyzes Moana‘s portrayal of the connection between nature and culture, and the possible consequences of severing this relationship.
Archetypal Development in One Body, One Image: Female Theatricality in Tennessee Williams's “A Streetcar Named Desire”
Authors: Comanelea Raluca 
Published: July 2020

ABSTRACTThis literary scholarship aims to trace the archetypal development of the female lead character in “A Streetcar Named Desire” by Tennessee Williams: Blanche DuBois. This fascinating character assumes almost as many archetypal female roles throughout the play as the roles an actress might accept over the course of a long career. Blanche's most important quality—her ability to seduce audiences into perceiving the multifaceted layers of her feminine character all at once—marks her entry into Williams's theatre of excess. Her theatricality springs precisely from her fascinating ability to reconstruct her persona in the course of the play, enacting the many possibilities contained in the word woman. Excess becomes Blanche's strategy for recreating possibilities and liberating conflicts. Blanche pours herself out with each page of the play so that every aspect of her identity is presented to the audience. Through the lens of desire and death, the many archetypal roles Blanche embodies are analyzed one by one, so that her womanly essence is revealed in all its intensity and excess. In a manner, Williams's own aesthetic sensibilities as a playwright are heavily invested in the multi‐faceted personas that Blanche DuBois brings to the stage.
The Princess is a Whore
Authors: Fleet Erin 
Published: July 2020

ABSTRACTSigmund Freud's creation of the “Madonna‐Whore” dichotomy has forever changed the way in which women are perceived in different forms of media and society as a whole. The three categories of the dichotomy are not necessarily wrong but are not categories at all; they are a journey that all women go through as they learn about their sexuality. While many want to criticize this journey and place women in just one stage forever, it is only a natural part of life and can be seen virtually everywhere. From the story of Adam and Eve, to original stories of the princesses like Cinderella, and even today in the lives of celebrities like Beyoncé, this paper discuss the way these women go through a journey of sexuality that seems to be viewed in a negative manner. It looks into the role that social media plays in allowing for this negativity to be given a platform in a time where there is an overwhelming amount of pressure on women and a very present rape culture.
Entertainment as Education: Multiculturalism and Interculturalism in Eytan Fox's 2004 Film Walk on Water
Authors: Engstrom Erika 
Published: July 2020

ABSTRACTThis article demonstrates how Israeli director Eytan Fox's 2004 film Walk on Water (Lalechet Al Ha‐Mayim) can be utilized to teach concepts of multiculturalism, interculturalism, and intercultural communication competence. A textual analysis of the film's visual and dialogic content demonstrates how narrative and aesthetic elements, such as those in Walk on Water, provide viewers cognitively and emotionally provocative stories that promote the pro‐social goals of intercultural communication.
The Return of the Repressed (and Oppressed): A Freudo‐Marxian Analysis of Jordan Peele's Us
Authors: Vannatta Seth 
Published: July 2020

ABSTRACTWhat are the necessary conditions for middle class life? This is the central question of Jordan Peele's horror movie, Us. I argue here that Peele's answer is both Freudian and Marxian, that these are interrelated, and that the tethered doubles of the Wilson family in Us represent their dynamic unconscious drive structures, the return of the repressed, and the revolutionary return of those oppressed by destructive effects of capitalism on a working underclass.
“Surface, surface, surface was all that anyone found meaning in”:American Psychoand the Pictures Generation
Authors: Giles Todd 
Published: July 2020

ABSTRACTMarking the twentieth anniversary of Mary Harron's film adaptation of Bret Easton Ellis'sAmerican Psycho(2000), this paper examines the artwork in Patrick Bateman's apartment to explore the ways in which this iconic 1980s Pictures Generation art reflects the same issues Bateman himself struggles with: the anxiety caused by the wholesale loss of identity and originality that plagued yuppies as they sleepwalked their way through the commodity fetishization and conspicuous consumption of 1980s America.
A invenção da memória: a disputa pelo legado do comunismo no Brasil entre o PCB e o PCdoB
Authors: Figueiredo César Alessandro Sagrillo 
Published: July 2020

Ao trabalharmos com partidos comunistas no Brasil, há um grande questionamento sobre qual seria o verdadeiro partido marxista-leninista nacional, visto que os dois partidos em atividades, respectivamente o PCB e o PCdoB, se reivindicam como o legítimo herdeiro da antiga agremiação fundada em 1922. Isso é endossado em documentos partidários, bem como declarado reiteradamente pela fala dos antigos militantes, que insistem em proferir um veredito final ativado pela memória dos anos de luta. Assim, a partir dessa disputa pelo legado, procuraremos, como objetivo deste artigo, discutir acerca da memória coletiva e da memória oficial no campo partidário, sobretudo no lócus da política, assim como visamos a examinar como essas memórias são ativadas enquanto trunfos políticos no tempo presente. Para efeitos metodológicos, trata-se de um trabalho qualitativo, voltado à reconstituição histórica, por meio das referências bibliográficas mais significativas e que respondam aos questionamentos propostos. Como resultado da pesquisa, verificamos que a memória oficial partidária é bastante seletiva e recortada, de acordo com os interesses políticos eleitorais, justamente a fim de manterem-se atuantes no cenário político e, também, constatamos que essa memória política conserva-se como objeto de conflito latente não amainado e permanecendo ativada no transcurso do tempo.
Deep Web e Dark Web: implicações sociais e repercussões jurídicas
Authors: Da Silva Fernanda Viero , Fornasier Mateus De Oliveira , Knebel Norberto Milton Paiva 
Published: July 2020

A presente pesquisa tem como objetivo geral investigar as características da Deep Web e da Dark Net, compreendendo aspectos conceituais de ambas nomenclaturas (que muitas vezes são confundidas como sinônimos), abordando-se como tais plataformas marcadas pelo expressivo anonimato operam na sociedade contemporânea pautada pela utilização massiva de tecnologias. Objetivos específicos: i) esclarecer as diferenças entre Deep Web e Dark Web, investigando-se também questões atinentes à evolução de tais noções; ii) estudar de que formas a Dark Web proporciona a existência de mercados clandestinos com diversas destinações e toda uma lógica capitalista; iii) apresentar criticamente algumas das estratégias estatais para o policiamento e investigação de tais plataformas, além de se debater como tais estratégias se relacionam ao direito à privacidade dos usuários. Resultado: embora a Dark Net ofereça ricos à sociedade em razão de atos ilícitos e cibercrimes nada mais é do que uma ferramenta da sociedade, e uma expressão da mesma, de seus anseios, intenções, subversões e mais profundas inseguranças. Metodologia: procedimento hipotético-dedutivo, com abordagem qualitativa e técnica bibliográfica-documental.
Improving Student Mathematics Understanding through Problem-Based Learning
Authors: Putri Cut Septiya , Anwar  , Usman  
Published: July 2020

This study aimed to improve students’ mathematics understanding through Problem-Based Learning. The subjects were Year 8 students in one of the junior high schools in Sigli, Indonesia. The main instrument used in this study was a mathematical understanding test, while the supporting instrument was the observation sheets of student and teacher activities. The data were analyzed qualitatively and described descriptively. The results showed that students' mathematics understanding reached the classical mastery learning of 62.50% and 75.00% for the cycle I and II, respectively. Based on these results, it can be concluded that the ability of mathematics understanding enhanced through the Problem-Based and Learning model.

Keywords: Problem-Based Learning, Mathematics Understanding, Junior High Schools.
Road Safety and Economic Development in Cameroon: An Analysis of the Kuznets Curve
Authors: Clement Nodem Meli , Ndjem Marie Louise Simone Nyonkwe Ngo , Steve Douanla Meli 
Published: July 2020

This article analyses the situation of road safety in Cameroon and its relationship with the country's level of economic development. The approach of Kuznets (1955) is applied to road accidents in Cameroon over a period from 1977 to 2016. The article identifies a Kuznets relationship for road accidents. The results of the analysis show that there is an inverted U-shaped relationship between road accidents and GDP per capita in Cameroon. The results of the analysis show that there is an inverted U-shaped relationship between road accidents and GDP per capita in Cameroon. Precisely the improvement of living conditions has first of all a negative impact on road safety up to a certain point called the inflection point which corresponds to a growth rate of GDP per capita between 7 and 8%, from this point on the improvement of living conditions positively influences road safety.
Keywords: road insecurity, economic development, Kuznets curve, economic development, Cameroon
A Floristic Composition of Woody Species and Potential Carbon Storage in Reforested Sites of Sudano-Sahelian Zone of Cameroon
Authors: Konsala Souare , Chimène Abib Fanta , Désiré Wadjou Bruce , Adamou Ibrahima 
Published: July 2020

The study examined the floristic diversity of woody species and their potential sequestration of carbon in reforested sites in sudano-sahelian zone of Cameroon. The experimental design was constituted of two blocks: Gaban and Matchoualta sites. In each block, a transect of 40 000 m2 (1 000 m x 40 m) was established. Four circular plots of 40 m of diameter were set up along the transect, and in each plot, all the woody individuals (dbh ≥ 5 cm) were inventoried. We used Origin 6.0 to perform the statistical analyses. Phytomass, storage and carbon credit of the woody individuals were estimated on the basis of allometric equations. At total of 3 098 woody individuals was inventoried and distributed within 62 species, 46 genera and 26 families. Fifty-six species were recorded in Gaban and fourty-nine species in Matchoualta site. Phytomass and carbon storage were 263.20 t/ha and 131.6 tC/ha for Gaban site, 213.61 t/ha and 106.80 tC/ha for Matchoualta site. The CO2 equivalent amounts were 482.97 CO2eq and 391.97 CO2eq. The total economic values of the two reforested sites were 2 624.82 ϵ/tCO2eq; 4 112.21 ϵ/tCO2eq and 87 794 ϵ/tCO2eq respectively for Clean Development Mechanism price, Voluntary carbon price and REDD+ price. Statistical analyses revealed that carbon stock values varied significantly between the two sites (ANOVA, F = 81.80; P = 0.012). The study provides valuable data useful for better management and monitoring of the two reforested sites with regard to tree carbon storage in mitigation of global warming and climate change.
Women in the shea industry: The case of Kusawgu in the Northern Region of Ghana
Authors: Naami Augustina , Naami Emmanuel Kwabena 
Published: July 2020

: This research sought to highlight the experiences of women in the shea industry in Kusawgu in Ghana. Recommendations to enhance and sustain the industry were also explored. A total of 60 women from four shea production groups, who lived in Kusawgu, participated in focus group discussions. The data was first analysed separately by the two researchers. Results were then compared to reconcile differences. The study demonstrates that the shea industry undoubtedly provided means of livelihood, self-dignity and respect for the women. Positive outcomes for working in groups include quick processing; sense of belonging and social capital; security and peace of mind; and skills development. However, lack of access to microfinance, travelling for longer distances, the period of time required to get water and fuel-wood, gender-based land ownership discrimination, and extinction of shea trees hamper production and income. Regardless of these challenges the women demonstrated resiliency by their continuous work in the industry. Due to the potential of the shea industry to reduce poverty among women, government should work hand-in-hand with the traditional authority to develop measures to sustain the industry. Social work practitioners could build the capability of the women in the shea industry to access existing pro-poor programmes.