bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factores e indicadores de riesgo de la periimplantitis como clave para su prevención
Authors: Castro Ruiz Carmen , Ortiz Culca Fernando 
Published: November 2019

La rehabilitación con implantes dentales es un tratamiento ya común en estos tiempos. Este tratamiento es considerado costoso, y requiere también de inversión de tiempo de parte del paciente/odontólogo tratante. Si el paciente presenta las condiciones ideales, el tiempo requerido desde la colocación del implante hasta su rehabilitación puede variar entre 2 a 6 meses; pudiendo este tiempo prolongarse, si el paciente requiere procedimientos quirúrgicos previos o conjuntamente a la colocación del implante. A pesar de la creciente aceptación y éxito de la rehabilitación con implantes dentales, se han reportado diversas complicaciones. Entre estas, la periimplantitis es cada vez mas frecuente, y a pesar de eso, es una enfermedad para la cual aún no se ha encontrado una cura 100% efectiva, conllevando muchas veces a la pérdida del implante dental. La periimplantitis es una enfermedad con una prevalencia, según la literatura, de 10% en implantes y 20% en pacientes, y que se espera aumente su ocurrencia a la par como va aumentando la frecuencia de las rehabilitaciones con implantes dentales. No se ha encontrado aún una causa específica para esta enfermedad, por lo que se han definido según varios estudios factores e indicadores de riesgo con la finalidad de prevenirla y tratarla tempranamente. Es por eso que esta revisión de literatura busca informar sobre cuáles son los factores e indicadores de riesgo conocidos actualmente para la periimplantitis.
Fascitis necrotizante de origen odontogénico: revisión de literatura y reporte de caso
Authors: Tetay Salgado Sindy , Rodríguez Cárdenas Yalil Augusto , Ruiz Mora Gustavo Armando 
Published: November 2019

La fascitis necrotizante (FN) es una infección poco común. Las primeras manifestaciones clínicas incluyen fiebre, dolor intenso, edema y enrojecimiento en el sitio de la herida. Esta patología se caracteriza por la evolución fulminante y la alta tasa de mortalidad que representa. El propósito del presente trabajo es describir las características de la fascitis necrotizante de origen odontogénico mediante la presentación de un caso clìnico y una revisión de la literatura y destacar las graves consecuencias que una infección dental podría desencadenar. Se resalta el enfoque multidisciplinario en estos casos y la interacción constante entre las diferentes especialidades médico-odontológicas para garantizar una gestión adecuada de cada caso.
Material Overview for Electrical Submersible Pumps: Part II—Polymeric and Other Materials
Authors: Xiao Jinjiang , Lastra Rafael , Roth Brian A. , Lee Woon 
Published: November 2019

SummaryElectrical submersible pumps (ESPs) are a key artificial-lift technology in the petroleum industry. Worldwide, installed ESPs in oil wells are in the range of 130,000 units, contributing to approximately 60% of the total oil production in the world. An ESP is made up of hundreds of components integrated to perform the lifting function. Materials in these components belong to several categories, including metals, ceramics, polymers, and others. A good understanding of these materials and vigilant selection for a specific application are critical to the reliability and run life of an ESP system. This series of papers provides an overview of all major classes of materials used in ESP systems. It is intended to serve as a reference for ESP field-application engineers who are responsible for the design, equipment longevity, and production optimization. This paper focuses on polymers and other materials.The information compiled in this paper is the result of an extensive literature review. We cover materials used in the motor, protector, pump, and cable (sensor, packer, Y-tool, diverter valve, surface components of variable-speed drives, and transformer are not included). For each class of materials, we identify relevant material properties and discuss suitable application conditions.
Ketamine affects the integration of developmentally generated granule neurons in the adult stage
Authors: Zhao Zhanqiang , Li Bing , Wu Yuqing , Chen Xujun , Guo Yan , Shen Yang , huang he 
Published: November 2019

Abstract
Background
Ketamine has been reported to cause neonatal neurotoxicity in a variety of developing animal models. Various studies have been conducted to study the mechanism of neurotoxicity for general anesthetic use during the neonatal period. Previous experiments have suggested that developmentally generated granule neurons in the hippocampus dentate gyrus (DG) supported hippocampus-dependent memory. Therefore, this study aimed to investigate whether ketamine affects the functional integration of developmentally generated granule neurons in the DG. For this purpose ， the postnatal day 7 (PND-7) Sprague-Dawley (SD) rats were divided into the control group and the ketamine group (rats who received 4 injections of 40 mg/kg ketamine at 1 h intervals). To label dividing cells, BrdU was administered for three consecutive days after the ketamine explore; NeuN+/BrdU+ cells were observed by using immunofluorescence. To evaluate the developmentally generated granule neurons that support hippocampus-dependent memory, spatial reference memory was tested by using Morris Water Maze at 3 months old, after which the immunofluorescence was used to detect c-Fos expression in the NeuN + /BrdU + cells. The expression of caspase-3 was measured by western blot to detect the apoptosis in the hippocampal DG.
Results
The present results showed that the neonatal ketamine exposure did not influence the survival rate of developmentally generated granule neurons at 2 and 3 months old, but ketamine interfered with the integration of these neurons into the hippocampal DG neural circuits and caused a deficit in hippocampal-dependent spatial reference memory tasks.
Conclusions
In summary, these findings may promote more studies to investigate the neurotoxicity of ketamine in the developing brain.
Evaluation of a new Rapid Antimicrobial Susceptibility system for Gram-negative and Gram-positive bloodstream infections: Speed and accuracy of Alfred 60 AST
Authors: Anton-Vazquez Vanesa , Samuel Adjepong , Cristina Suarez , Timothy Planche 
Published: November 2019

Abstract
Background: Blood stream infections (BSIs) are a major cause of morbidity and mortality. The time from taking blood cultures to obtain results of antibiotic sensitivity can be up to five days which impacts patient care. The Alfred 60 AST™ can reduce laboratory time from positive culture bottle to susceptibility results from 16-25 hours to 5-6 hours, transforming patient care.

Objective: To evaluate the diagnostic accuracy of a rapid antimicrobial susceptibility system, the Alfred 60 AST™, in clinical isolates from patients with BSIs and confirm time to results.

Methods: 301 Gram-negative and 86 Gram-positive isolates were analysed directly from positive blood culture bottles following Gram staining. Antimicrobial susceptibility results and time-to-results obtained by rapid Alfred 60 AST system and BD Phoenix were compared .

Results : A total of 2,196 antimicrobial susceptibility test results (AST) were performed: 1,863 Gram-negative and 333 Gram-positive. AST categorical agreement (CA) for Alfred 60 AST™ was 95% (1772/1863) for Gram-negative and 89% (295/333) for Gram-positive isolates. Gram-negative CA: ampicillin 96% (290/301); ciprofloxacin 95% (283/297); ceftriaxone 96% (75/78); meropenem 97% (288/297); piperacillin-tazobactam 95% (280/295); gentamicin 94% (279/297) and amikacin 93% (277/298). The median time to susceptibility resultsfrom blood culture flagging positive was 6.3 h vs 20 h ( p<0.01 ) for Alfred system vs BD Phoenix™.

Conclusion: Alfred 60 AST system greatly reduced time to antimicrobial susceptibility results in Gram-negative and Gram-positive BSIs with good performance and cost, particularly for Gram-negative bacteraemia.

Keywords: Rapid diagnostics. Bloodstream infection. Bacteraemia. Antimicrobial susceptibility testing. Gram-negative bacteria. Gram-positive bacteria
High index of suspicion for brucellosis in a highly cosmopolitan city in southern China
Authors: Ye Hai-Yan , Xing Fan-Fan , Yang Jin , Lo Simon Kam-Fai , Lau Ricky Wing-Tong , Chen Jonathan Hon-Kwan , Chiu Kelvin Hei-Yeung , Yuen Kwok-Yung 
Published: November 2019

Abstract
Background: Brucellosis is one of the most widespread zoonosis in the world. In China, 90% of human brucellosis occurs in six northern agricultural provinces. However, there is a recent increase in the trend of human brucellosis in southern provinces with limited cases reported in the literature. Our study aims to describe the clinical features and epidemiology of brucellosis in a tertiary hospital in southern China.
Methods: A retrospective case series of brucellosis was conducted between January 1, 2014 and October 31. 2018. Cases were identified based on positive Brucella serology by tube agglutination test, or positive culture from clinical specimen identified by Vitek 2 and MALDL-TOF MS. Clinical details of brucellosis including patients’ occupation, risk factors, and complications were analyzed. Clinical characteristics between patients from Guangdong and other provinces were also compared.
Results: A total of 13 cases of laboratory-confirmed brucellosis were identified. 7 (53.8%) of the patients were male, 6 (46.2%) were female, with age ranging from 29 to 73 years old (median age: 51 years). Five patients (38.5%) were from Guangdong province, while the remaining patients (61.5%) were from other provinces. The commonest risk factors of acquisition were consumption of undercooked meat and goat placenta. Patients from Guangdong province were found to be more likely to have prior placenta consumption and handling of animal meat. The commonest clinical presentations were fever, osteoarticular pain, urinary symptoms, splenomegaly, and lymphadenopathy. Spondylodiscitis/ peripheral joint arthritis (5 patients, 38.5%) was the most prevalent complication, while extra-osteoarticular complications including abdominal aortitis, hepatosplenic abscess, chest wall abscess, and epididymo-orchitis were observed in 4 other patients. Furthermore, it was demonstrated that MALDI-TOF MS is reliable in Brucella identification after additional of reference spectra with standard Brucella strain.
Conclusions: Brucellosis, previously thought to be only found in northern China, is now increasingly seen in highly cosmopolitan part of southern China. MALDI-TOF MS in hospitals in China should include reference spectra with standard Brucella strain to aid bacterial identification in routine clinical practice. In addition to tuberculosis, typhoid fever and typhus, brucellosis should be considered in patients with fever of unknown origin in this locality.
Comprehensive gene expression analysis for exploring the association between glucose metabolism and differentiation of thyroid cancer
Authors: Suh Hoon Young , Choi Hongyoon , Paeng Jin Chul , Cheon Gi Jeong , Chung June-Key , Kang Keon Wook 
Published: November 2019

Abstract
Background: The principle of loss of iodine uptake and increased glucose metabolism according to dedifferentiation of thyroid cancer is clinically assessed by imaging. Though these biological properties are widely applied to appropriate iodine therapy, the understanding of the genomic background of this principle is still lacking. We investigated the association between glucose metabolism and differentiation in advanced thyroid cancer as well as papillary thyroid cancer (PTC). Methods: We used RNA sequencing of 505 patients with PTC obtained from the Cancer Genome Archives and microarray data of poorly-differentiated and anaplastic thyroid cancer (PDTC/ATC). The signatures of GLUT and glycolysis were estimated to assess glucose metabolic profiles. The glucose metabolic profiles were associated with tumor differentiation score (TDS) and BRAFV600E mutation status. In addition, survival analysis of glucose metabolic profiles was performed for predicting recurrence-free survival. Results: In PTC, the glycolysis signature was positively correlated with TDS, while the GLUT signature was inversely correlated with TDS. These correlations were significantly stronger in the BRAFV600E negative group than the positive group. Meanwhile, both GLUT and glycolysis signatures were negatively correlated with TDS in advanced thyroid cancer. The high glycolysis signature was significantly associated with poor prognosis in PTC in spite of high TDS. The glucose metabolic profiles are intricately associated with tumor differentiation in PTC and PDTC/ATC. Conclusions: As glycolysis was an independent prognostic marker, we suggest that the glucose metabolism features of thyroid cancer could be another biological progression marker different from differentiation and provide clinical implications for risk stratification.
Mental distress, perceived need and barriers to receive professional mental health care among university students
Authors: Negash Assegid , Ahmed Matloob , Medhin Girmay , Wondimagegn Dawit , Araya Mesfin 
Published: November 2019

Abstract
Context: There is limited evidence on the extent of the perceived need for professional mental health care and barriers to the delivery of mental distress services among university students in low and middle-income countries. Objective: The current study was designed to assess the prevalence of mental distress, perceived need for professional mental health care and barriers to the delivery of the service for regular undergraduate university students. Methods: A multi-stage sampling technique was used to recruit 1135 regular undergraduate university students. Symptoms of mental distress were evaluated using the Self-Reported Questionnaire (SRQ-20) and a score of eight and above was used to identify positive cases. The perceived need for professional mental health care was assessed using one question with binary responses, whereas barriers to mental health care were assessed using Barriers to Access to Care Evaluation (BACE-30) tool. The association of demographic variables with total mean scores of BACE-III sub-scales was modeled using multiple linear regression. Results: The prevalence of mental distress symptoms was 34.6% and the perceived need for professional mental health care was 70.5%. The top five barriers to receiving professional mental health service were (a) thinking the problem would get better by itself, (b) being unsure where to go to get professional care, (c) wanting to solve the problem by own, (d) denying mental health problem, and (e) preferring to get alternative forms of mental care. Conclusions: The high prevalence of mental distress, mental health care gap, and the report of barriers to professional mental health care among Ethiopian regular undergraduate students is a call for action. Keywords: Mental distress, Perceived need, Barrier, and Professional mental health care.
The long-term efficacy of one-shot neoadjuvant intra-arterial chemotherapy combined with radical cystectomy versus radical cystectomy alone for bladder cancer: a propensity-score matching study
Authors: Wahafu Wasilijiang , Liu Sai , Xu Wenbin , Wang Mengtong , He Qingbao , Song Liming , Wang Mingshuai , Yang Feiya , Hua Lin , Niu Yinong , Xing Nianzeng 
Published: November 2019

Abstract
Background:
Bladder cancer is a complex disease associated with high morbidity and mortality. Management of bladder cancer before radical cystectomy continues to be controversial. We compared the long-term efficacy of one-shot neoadjuvant intra-arterial chemotherapy (IAC)versus no IAC (NIAC) before radical cystectomy (RC) for bladder cancer.

Methods:
We performed a retrospective review of patients who underwent either one-shot IAC or NIAC before RC between October 2006 and November 2015. A propensity-score matching (1:3) was performed based on key characters. The Kaplan-Meier method was utilized to estimate survival probabilities, and the log-rank test was used to compare survival outcomes between different groups. A multivariable Cox proportional hazard model was used to estimate survival outcomes.

Results:
Twenty-six patients were treated using IAC before RC, and 123 NIAC patients also underwent RC. After matching, there was no significant difference between groups in baseline characteristics, perioperative variables, complication outcomes or tumor characteristics. Compared with clinical tumor stages, pathological tumor stages demonstrated a significant decrease (P=0.002) in the IAC group. There was no significant difference in overall survival (OS, p=0.354) or cancer-specific survival (CSS, p=0.439) between the groups. Among all patients, BMI significantly affected OS (p=0.004), and positive lymph nodes (PLN) significantly affected both OS (p＜0.001) and CSS(p=0.010).

Conclusions:
One-shot neoadjuvant IAC before RC shows safety and tolerability and provides a significant advantage in pathological downstaging but not in OS or CSS. Further study of neoadjuvant combination therapeutic strategies with RC is needed.
Association between anemia and frailty in 13,175 community-dwelling adults aged 50 years and older in China
Authors: Ruan Ye , Guo Yanfei , Kowal Paul , Lu Ye , Liu Chazhen , Sun Shuangyuan , Huang Zhezhou , Zheng Yang , Wang Wenjing , Li Gan , Shi Yan , Wu Fan 
Published: November 2019

Abstract
Background: Anemia and frailty contribute to poor health outcomes in older adults; however, most current research in lower income countries has concentrated on anemia or frailty alone rather than in combination. The aim of the present study was to investigate the association between anemia and frailty in community-dwelling adults aged 50 years and older in China. Methods: The study population was sourced from the 2007/10 SAGE China Wave 1. Anemia was defined as hemoglobin less than 13g/dL for men and less than 12g/dL for women. A Frailty Index (FI) was compiled to assess frailty. The association between anemia and frailty was evaluated using a 2-level hierarchical logistic model. Results: The prevalence of anemia was 31.0% (95%CI: 28.4%, 33.8%) and frailty 14.7% (95%CI: 13.5%, 16.0%). In the univariate regression model, presence of anemia was significantly associated with frailty (OR=1.62, 95% CI: 1.39, 1.90) and the effect remained consistent after adjusting for various potential confounding factors including age, gender, residence, education, household wealth, fruit and vegetable intake, tobacco use, alcohol comsumption and physical activity (adjusted OR =1.31, 95% CI:1.09, 1.57). Each 1 g/dL increase in hemoglobin concentration was associated with 4% decrease in the odds of frailty after adjusting for several confounding variables (adjusted OR =0.96, 95% CI: 0.93, 0.99). Conclusion: Anemia and low hemoglobin concentrations were significantly associated with frailty. Therefore, health care professionals caring for older adults should increase screening, assessment of causes and treatment of anemia as one method of avoiding, delaying or even reversing frailty.
Diagnostic and prognostic value of interleukin-6, pentraxin 3, and procalcitonin levels among sepsis and septic shock patients: a prospective controlled study according to the Sepsis-3 definitions
Authors: Song Juhyun , Park Dae Won , Moon Sungwoo , Cho Han-Jin , Park Jong Hak , Seok Hyeri , Choi Won Seok 
Published: November 2019

Abstract
Background: This study investigated the clinical value of interleukin-6 (IL-6), pentraxin 3 (PTX3), and procalcitonin (PCT) in patients with sepsis and septic shock diagnosed according to the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).
Methods: Serum levels of IL-6, PTX3, and PCT were measured in 142 enrolled subjects (51 with sepsis, 46 with septic shock, and 45 as controls). Follow-up IL-6 and PTX3 levels were measured in patients with initial septic shock within 24 hours of hospital discharge. Optimal cut-off values were determined for sepsis and septic shock, and prognostic values were evaluated.
Results: Serum IL-6 levels could discriminate sepsis (area under the curve [AUC], 0.83–0.94, P < 0.001; cut-off value, 52.60 pg/mL, 80.4% sensitivity, 88.9% specificity) from controls and could distinguish septic shock (AUC, 0.71-0.89; cut-off value, 348.92 pg/mL, 76.1% sensitivity, 78.4% specificity) from sepsis. Twenty-eight-day mortality was significantly higher in the group with high IL-6 (≥ 348.92 pg/mL) than in the group with low IL-6 (< 348.92 pg/mL) (P = 0.008). IL-6 was an independent risk factor for 28-day mortality among overall patients (hazard ratio, 1.0004; 95% confidence interval, 1.0003–1.0005; p = 0.024). In septic shock patients, both the initial and follow-up PTX3 levels were consistently significantly higher in patients who died than in those who recovered (initial p = 0.004; follow-up P < 0.001).
Conclusions: The diagnostic and prognostic value of IL-6 was superior to those of PTX3 and PCT for sepsis and septic shock.
L-3-n-butylphthalide attenuates inflammation and brain edema in rat intracerebral hemorrhage model
Authors: Zeng Zhou , Gong Xiyu , Hu Zhiping 
Published: November 2019

Abstract
Background：Previous studies have shown that L-3-n-butylphthalide(NBP), which is a compound found in Apium graveolens Linn seed extracts, could have therapeutic effects on acute ischemic stroke through anti-inflammation and by reducing brain edema. The pathological inflammatory pathways and consequent brain edema in intracerebral hemorrhage (ICH) share some characteristics with ischemic stroke. Methods：We hypothesized that NBP has anti-inflammatory and therapeutic effects on rats with ICH. ICH was induced by an infusion of bacterial collagenase type IV into the unilateral striatum of anesthetized rats. The therapeutic effect of NBP was measured by assessing neurological function, brain water content, blood-brain barrier permeability, and expression of tumor necrosis factor-alpha (TNF-α) and matrix metalloproteinase-9 (MMP-9) around the hematoma 48 hours after surgery. Magnetic resonance imaging (MRI) was performed 4 and 48 hours after ICH induction, and ICH-induced injured area volumes were measured using T2-weighted images. Results： The NBP treatment group performed better in the neurological function test than the vehicle group. Moreover, in comparison with the vehicle group, NBP group showed a lower expanded hematoma volume, brain water content, blood-brain barrier permeability, and TNF-α/ MMP-9 expression level. Conclusions：Our results suggested that NBP attenuates inflammation and brain edema in rat ICH model. Therefore, our findings also show the potential for clinical application of NBP in the treatment of ICH. Keywords: L-3-n-butylphthalide; intracerebral haemorrhage; blood-brain barrier; brain edema; anti-inflammation