bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mental health and psychosocial support for families of missing persons in Sri Lanka a retrospective cohort study
Authors: Andersen Ida , Poudyal Bhava , Abeypala Arundathi , Uriarte Carla , Rossi Rodolfo 
Published: March 2020

Abstract
Background: The International Committee of the Red Cross (ICRC) has developed its ‘Accompaniment model’ to address the multi-faceted needs of relatives of people who go missing during armed conflict. In Sri Lanka an Accompaniment Programme was launched in 2015 for the relatives of the more than 16,000 missing persons who remain unaccounted for. Method: 1,783 relatives who took part in the mental health and psychosocial support (MHPSS) component of the ICRC’s Accompaniment Programme in Sri Lanka between April 2016 and August 2017 were offered eight peer-support group sessions, individual home visits, referrals to local services, and commemoration events to pay tribute to their missing relatives. Symptoms of anxiety and depression (using the HADS scale), somatic difficulties (using the BSI scale) and daily functioning (ICRC scale) were assessed before and after the MHPSS intervention. Results: Prior to receiving support, Tamil and Muslim ethnicity, ≥60 years of age and civilian status were predictors of severe symptoms of anxiety; Tamil ethnicity, ≥50 years of age and being the mother of a missing person were predictors of severe symptoms of depression; and ≥50 years of age and severe symptoms of anxiety and depression were predictors of severe somatic difficulties. After receiving support, the vast majority of the relatives of missing persons showed reduced levels of anxiety (81%), depression (79%) and somatic pain (77%), as well as increased functioning (75%). Predictors of improvement following support were severe levels of distress at baseline and Tamil and Muslim ethnicity. In addition, attending at least three group sessions was a predictor of decreased anxiety, age group 51-60 was a predictor of decreased depression, female gender was a predictor of decreased somatic difficulties, and referrals were a predictor of increased functioning. Conclusion: The MHPSS component of the ICRC’s Accompaniment Programme is a relevant approach to helping families to cope with not knowing the fate and whereabouts of their missing relatives, to reduce distress, to break their social isolation and to resume more functional lives. However, further research is needed, possibly through a controlled trial, to better establish the effectiveness of this approach.
Prevalence of Risk factors for non-communicable chronic disease in Shaanxi province of China
Authors: Author) Weihua Wang(Former Corresponding , Qiu Lin , Sa Rina , Li Xia , Author) Feng Liu(New Corresponding , Zhou Zhongliang 
Published: March 2020

Abstract
Background

Risk factors including both behavioral risk factors (BRFs) and biological risk factors contribute majorly to the development of non-communicable chronic diseases. We aimed to explore the covariation, cluster and distribution of risk behaviors in Shaanxi province of China.

Methods

Multistage clustering sampling was adopted to select participants for the survey. We obtained the data and investigate the prevalence and clustering pattern (mean number of risk factors) of eight risk factors for non-communicable chronic diseases, including four behavioral risk factors (smoking, drinking, consumption of fruit and vegetables, physical activity) and four biological risk factors (overweight and obesity, raised blood pressure, raised fasting blood glucose and raised total serum cholesterol). Ordinal logistic regression was conducted to investigate the independent demographic and socioeconomic covariates of clustering of the eight risk factors.

Results

The prevalence of eight risk factors in Shaanxi province were found: insufficient fruit and vegetable intake,59.82%; overweight and obesity, 46.82%; raised blood pressure, 30.88%; current smoking, 28.21%; physical inactivity, 24.63%; raised total serum cholesterol, 20.96%; raised blood glucose, 4.27% and harmful use of alcohol, 2.16%. 64.73% of the Chinese in Shaanxi province had two or more risk factors. Being a male, old, living in rural areas, having a lower education level and being separated, divorced or widowed all tends to have more risk factors.

Conclusion

There is a high prevalence of risk factors for non-communicable chronic diseases among residents in Shaanxi province of China. Public health interventions are needed to reduce these risk factors and ought to target those who are male, old, poorly educated and live in rural areas.
Multi-methodological study of Early Modern Age archaeological glazed ceramics from Prague
Authors: Klouzkova Alexandra , Kohoutkova Martina , Kolarova Maria , Blazkova Gabriela , Sefcu Radka , Dvorakova Pavla , Kmonickova Martina Bajeux 
Published: March 2020

Abstract
A set of scientific methods (X-ray analyses, optical and electron microscopy, Raman spectroscopy and thermal analyses) was used for research of ceramic bodies and glazes of forty vessels from Renaissance Prague. The set of early modern age archaeological glazed ceramics contained tableware, kitchenware and technical ceramics. The main aim was to characterize ceramic materials and glazes over two centuries. Attention was also paid to identification of defects and corrosion products of the glazes. The research was conducted with an emphasis on the context of the original use of ceramic artefacts and the environment of waste pits from which they were excavated. Among the archaeological finding, three vessels of technical ceramics were found (a rectifier, a bowl and a jar) which together could have formed a distillation apparatus. Since these vessels represent a unique finding, they were subjected to a detailed survey. Based on the similarity of ceramic bodies and glazes, it was proved that the three vessels of technical ceramics were made in the same workshop and were parts of one distillation apparatus. The results of the performed analyses proved that the studied vessels were manufactured from raw materials with high content of a plastic component and that the raw materials did not change significantly during the period from 15th to 18th centuries. The firing temperature of most of the vessels did not exceed 1000 °C. It was proved that all glazes were middle- or high-lead glazes and were coloured with ionic pigments.
Functional MYB transcription factor gene HtMYB2 is associated with anthocyanin biosynthesis in Helianthus tuberosus L.
Authors: Gao Jieming , Zong Yuan , Yang Shipeng , Wang Lihui , Liu Baolong , Sun Xuemei 
Published: March 2020

Abstract
Background: Tuber color is an important trait for Helianthus tuberosus L. (Jerusalem artichoke), but the molecular mechanism underlying it is unknown. Results: In the current study, high-throughput RNA-sequencing was used to compare the transcriptomes between plants with tubers with red or white epidermis. Compared with the white-skinned tubers of cultivar QY3, anthocyanin biosynthesis structural genes had greater expression in the red-skinned tubers of cultivar QY1, indicating that the anthocyanin biosynthesis pathway was activated in ‘QY1’; quantitative PCR confirmed this difference in expression. HtMYB2 (Unigene44371_All) was the only MYB transcription factor expressed in the red tuber epidermis of ‘QY1’. HtMYB2 resembled an MYB transcription factor, regulating anthocyanin biosynthesis, and possessing an intact SANT/MYB and MYB-like DNA-binding domain. The anthocyanin concentration in the root, stem, leaf, flower, and tuber epidermis of ‘QY1’ was higher than in ‘QY3’, especially tuber epidermis. Correspondingly, HtMYB2 had greater expression in these tissues of ‘QY1’ than in ‘QY3’. The expression of HtMYB2 was associated with anthocyanin accumulation in the different tissues. Overexpression of HtMYB2 activated the anthocyanin biosynthesis pathway, accumulating the pigment in leaves of transgenic tobacco, supporting the model that HtMYB2 regulated anthocyanin biosynthesis. Further experiments found that HtMYB2 had the same coding sequence and genomic sequence in ‘QY1’ and ‘QY3’, but that there were several single nucleotide polymorphisms and one insertion–deletion (indel) mutation of 21 nucleotides in the promoter region between the two alleles. The deletion of three nucleotides “AAA” made the promoter of ‘QY1’ predicted to contain one more possible promoter region. A specific primer, based on the indel, could differentiate between cultivars with red or white tuber epidermis. The genetic variation in HtMYB2 was associated with the tuber skin color in a natural population.Conclusions: RNA-seq can successfully isolate the candidate gene (HTMYB2) controlling anthocyanin biosynthesis in purple epidermis of Jerusalem artichoke tuber. HTMYB2 can regulate anthocyanin biosynthesis in plants and is closely related to the formation of purple phenotype in tubers. This study should be useful in understanding the genetic mechanism underlying different tuber skin colors and in breeding new H. tuberosus cultivars with different tuber skin colors.
Treatment of thoracolumbar fracture-dislocation with a trauma limitation strategy: a technical report and 2-year follow-up
Authors: wu fujun , hou genyi , huang nijiao , ju songli , Author) xin wang(New Corresponding , ao jun 
Published: March 2020

Abstract
Background: To investigate the curative effect of limited traumatic surgical strategy for thoracolumbar fracture-dislocation. Methods : Twenty-two patients with thoracolumbar fracture-dislocation who were admitted to our department from May 2013 to January 2016 were 16 males and 6 females, aged 21-53 years. All patients were associated with varying degrees of spinal nerve injury. Twenty-two patients were randomly assigned to the percutaneous minimally invasive group (group A) and the intermuscular approach group (group B). Among them, 11 patients in group A underwent percutaneous minimally invasive pedicle screw fixation combined with small incision for spinal canal reduction. Pressure and interbody fusion: 11 patients in group B underwent transpedicular space fixation with pedicle screw fixation combined with partial decompression and bone graft fusion. The operation time and intraoperative blood loss were recorded in the two groups. Visual analog scale (VAS) was recorded at 3 days and terminal follow-up. The fracture healing and spinal cord invasion rate were evaluated by imaging examination before and after the final follow-up. The neurological recovery was assessed according to the ASIA grading criteria. Result : There was a statistically significant difference between the two groups in the operation time and intraoperative blood loss (P<0.05). The VAS scores of the lumbar dorsal incision were compared between the two groups at the same time point, and the difference was statistically significant (P<0.05). Imaging examination showed that the fracture healed well and there was no internal fixation fracture. The rate of spinal canal invasion in the fracture and dislocation segments of the two groups was compared at the final follow-up, and the difference was statistically significant. Neurological recovery at the last follow-up (ASIA classification): 6 patients with grade A, 6 patients with grade B, 7 patients with grade C, 2 patients with grade D, and 1 patient with grade E, with significant improvement compared with preoperative. Conclusion : Percutaneous minimally invasive pedicle screw fixation combined with small incision decompression of the spinal canal and interbody fusion can also achieve the effect of posterior open surgery, and the trauma is smaller, which is more conducive to postoperative rehabilitation and reduce surgical complications.
Relationship between pre-existing kyphosis and new vertebral compression fractures following percutaneous vertebroplasty in patients with osteoporotic thoracolumbar fracture.
Authors: Chen Chao , Yu Ronghua , Chen Liwei , Wang Silian , Li Zhikun , Xu Youjia 
Published: March 2020

Abstract
Background: Thoracolumbar kyphosis disrupts the overall balance of the spine, thus the stress on each segment of the spine is different from that of the normal sequence. This may affect the outcome after Percutaneous vertebroplasty (PVP). But few studies have examined the relationship between thoracolumbar kyphosis and new fractures after PVP. Methods: A cross-sectional was conducted to evaluate the effect of the thoracolumbar kyphosis angle on postoperative recurrent fractures in patients with osteoporotic thoracolumbar fractures. From 2013 to 2018, 486 patients were treated with PVP in our hospital, and 242 patients were included in the study. These patients were divided into groups A and B based on the Cobb angle (greater or less than 10 °) in the thoracolumbar region. Patients were followed up for 36 months. The average CT value of the thoracolumbar spine, BMD, and the time of recurrence of fractures were recorded. Results: A clear relationship was observed between thoracolumbar Cobb kyphosis and recurrent vertebral fractures (OR = 1.061, P = 0.003). In group A, the proportion of women was larger and the BMD values was lower than that in group B. But no difference was found in the average CT value. K-M survival analysis found no significant difference in the rate of fracture recurrence between the two groups, but the time interval of second fracture occured at adjacent levels was significantly shorter than that occurred at distant levels in group A, which was not found in group B. Conclusions: When patients have thoracolumbar kyphosis before surgery, PVP should not be a recommended treatment.
Resurgence risk for malaria, characterization of a recent outbreak in a Amazonian border area -French Guiana/Brazil-
Authors: MOSNIER Emilie , Dusfour Isabelle , Lacour Guillaume , Saldanha Raphael , Guidez Amandine , Gomes Margarete S. , Sanna Alice , Epelboin Yanouk , Restrepo Johana , Davy Damien , Demar Magalie , Djossou Félix , Douine Maylis , Ardillon Vanessa , Nacher Mathieu , Musset Lise , Roux Emmanuel 
Published: March 2020

Abstract
Background In 2017, inhabitants along the border between French Guiana and Brazil were affected by a malaria outbreak primarily due to Plasmodium vivax ( Pv ). While malaria cases have steadily declined between 2005-2016 in this Amazonian region, a resurgence was observed in 2017. Methods Two investigations were performed according to two different spatial scales and type of information details. Firstly, a local study on the French Guiana border, which enabled a thorough investigation of the malaria cases treated at the local village health center and of the entomological situation in the most affected neighborhood and secondly a regional and cross-border study, which enabled exploration of the regional spatial-temporal epidemic dynamic. Number and location of malaria cases were estimated using French and Brazilian surveillance systems. Results On the French Guiana side of the border in Saint Georges de l’Oyapock, the attack rate was 5.5% (n=219/4000), reaching 51.4% (n=90/175) in one Amerindian neighborhood. Entomological findings suggest a peak of Anopheles darlingi density in August and September. Two female An. darlingi (n=2/1104, 0.18%) were found Pv -positive during this peak. During the same period, aggregated data from passive surveillance conducted by Brazilian and French Guianese border health centers identified 1,566 cases of Pv infection. Temporal distribution during the 2007-2018 period displayed seasonal patterns with a peak in November 2017. Four clusters were identified among the epidemic profiles of the localities of the cross-border area. All localities of the first two clusters were Brazilian. The localization of the first cluster suggests an onset of the outbreak in the Amerindian reservation, subsequently expanding to French Amerindian neighborhoods and to non-Native communities. Conclusions The current findings demonstrate a potential increase in malaria cases in an area with otherwise declining numbers. This is a transborder area where human mobility and remote populations challenge malaria control programs. This investigation illustrates the importance of international border surveillance and collaboration for malaria control, particularly in Amerindian villages and mobile populations.
Epidemiology and risk factors of infective endocarditis in a tertiary hospital in China from 2007 to 2016
Authors: Wu Zhenzhu , Chen Yi , Xiao Tingting , Niu Tianshui , Shi Qingyi , xiao yonghong 
Published: March 2020

Abstract
Background: To explore the trends in epidemiology and risk factors related to the prognosis of infective endocarditis in a teaching hospital over the past ten years. Methods: A retrospective cohort study was performed. A total of 407 consecutive patients were included. The clinical characteristics and risk factors related to the prognosis of infective endocarditis during this period were analyzed. Results: A total of 407 patients with infective endocarditis were included, the average age was 48 ±16 years old with an increasing trend and in-hospital mortality rate was 10.6% and one-year mortality rate was 12.2%. Among patients with underlying heart disease, congenital heart disease was the most common(25.8%), followed by rheumatic heart disease which showed a decreased trend during this period (P<0.001). There were 222(54.5%) positive blood cultures and streptococci (44.1%) was the main pathogens with an increasing trend. There were 403 patients (99%) with surgical indications, but only 234 patients (57.5%) received surgical treatment. Hemodialysis (P = 0.041, OR = 4.697, 95% CI 1.068-20.665), pulmonary hypertension (P = 0.001, OR = 5.308, 95% CI 2.034-13.852), Pitt score ≥ 4 (P <0.001, OR = 28.5, 95% CI 5.5-148.1) and vegetation length＞30mm (P = 0.011, OR = 13.754, 95% CI 1.832-103.250) were independent risk factors for in-hospital mortality. Conclusions: There was no significant change in the overall incidence of IE, the clinical features of IE have changed slightly during the past ten years. Streptococci IE was still the predominant. IE patients with hemodialysis, pulmonary hypertension, Pitt score ≥ 4 and vegetation length＞30mm had an worse in-hospital outcome.
Atrial function after treatment of atrial septal defects in children under 5 years
Authors: Choi Eun-Young , Kim Eun Sun , Kim Jung-Yoon , Park Su-Jin , Yoon Ja-kyoung , Noh Chung Il 
Published: March 2020

Abstract
BackgroundRecently, the patient’s age of atrial septal defect (ASD) treatment has been gradually decreasing. However, the most appropriate age and treatment method remain controversial. We hypothesized that treatment of ASDs in patients under 5 years would be able to adequately normalize bi-atrial function over one year after treatment. The purpose of this study is to confirm the normalization of hypothesized atrial function.MethodsData of fifteen patients who underwent surgical ASD closure under 5 years of age (Operation group), 15 patients who underwent percutaneous ASD closure (Device group), and 15 age- and gender-matched normal control patients (Control group) were extracted from our echocardiographic data. Conventional 2D images and 2D speckle tracking method were used to evaluate bi-atrial function.ResultsLeft atrial function, εS, εE, and εA showed no significant differences in the three groups. Indicators representing the right atrial function varied with the three groups. However, there were no significant differences in the global longitudinal strain of the right atrium between the Operation and Device groups.ConclusionsAfter ASD treatment, right atrial function recovery is less than that of the left atrium. The function of the right atrium is not normalized after more than one year of treatment for ASD in patients under 5 years. After ASD treatment, further follow-up of the bi-atrial function is necessary.
Perspectives on illness-related stigma and electronically sharing psychiatric health information by people with Multiple Sclerosis.
Authors: Yu Eileen , Adams-Clark Alexis , Riehm Alison , Franke Caroline , Susukida Ryoko , Pinto Melissa , Arenberg Steven , Tosi Dominique , Hughes Abbey , Montague Amanda , Kumar Anupama , Jamison Kay , Kaplin Adam 
Published: March 2020

Abstract
Background: Electronic medical records (EMRs) have transformed the way healthcare professionals manage and share patient data while providing integrated and comprehensive care. However, the rate of EMR use among psychiatrists is generally lower compared to physicians in other medical disciplines, in part due to concerns over patients’ experience of stigma surrounding mental health. This paper explores the willingness to share medical records among people with multiple sclerosis (MS), who experience higher rates of psychiatric comorbidities compared to the general population. It also examines the role that stigma plays in patients’ preferences regarding the sharing of their electronic medical records. Methods: MS patients were surveyed regarding their co-occurring psychiatric and non-psychiatric diagnoses, willingness to share their health information electronically among their treating doctors, and levels of self and societal stigma associated with their various co-occurring diagnoses. Results: 96.44% and 87.14% of participants were willing to share their non-psychiatric and psychiatric diagnoses, respectively; 97.70% and 92.78% were willing to share non-psychiatric and psychiatric medications, respectively. MS patients with a psychiatric co-occurring diagnosis, compared to those without, were significantly more likely to share their psychiatric diagnosis (AOR = 2.59) and psychiatric medications (AOR = 3.19). Those with both non-psychiatric and psychiatric co-occurring diagnoses were significantly more likely to share their psychiatric diagnosis (AOR = 3.84) and psychiatric medications (AOR = 7.02) than patients with no co-occurring diagnosis other than MS. Five (substance use, personality, eating, psychotic, and neurodevelopmental disorders) of the top six diagnoses for which societal stigma was greater than self stigma, and three (sexual, anxiety, and mood disorders) of the top five diagnoses for which self stigma was greater than societal stigma were psychiatric diagnoses. High levels of societal stigma correlated with decreased likelihood in sharing non-psychiatric medications, while high levels of self stigma were associated with a greater decrease in patient willingness to share psychiatric medications. Conclusions: Despite the presence of stigma decreasing patient willingness to share medical records, people with MS who had psychiatric disorders, compared to those without, endorsed greater willingness to share their health records electronically.