bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efeitos da aplicação de boro via solo e foliar na qualidade da semente de amendoim
Authors: Betiol Ruan Aparecido Biagi , Vitti Godofredo Cesar , Heuert Jair , Xavier Maxuel Fellipe Nunes 
Published: October 2020

O objetivo deste estudo foi avaliar a qualidade das sementes de amendoim em função da aplicação de B via foliar e associada com via solo. Os experimentos foram desenvolvidos em uma área de reforma de cana-de-açúcar no município de Ribeirão Bonito-SP, no ano agrícola 2018/19. O estudo foi realizado em delineamento experimental com blocos casualizados, com 4 repetições. No primeiro experimento, foi realizado aplicações foliares de ácido bórico (Bab: doses 0, 250, 500, 750, 1000 e 1250 g ha-1). Enquanto, no segundo experimento aplicou o octaborato de sódio, via solo, (Boct: dose 500 g ha-1), associado com a aplicação de ácido bórico, via foliar (Bab: doses 0, 250, 500, 750, 1000 e 1250 g ha-1 de B). As parcelas foram de 3,6 metros de largura, com 4 linhas de plantio de espaçamento 0,90 m, 20 metros de comprimento e um estande médio de 12 plantas por metro. A cultivar utilizada foi a IAC OL4. O plantio foi realizado no dia 10 de outubro 2018, com o arranquio 127 dias após o plantio. A aplicação do boro via foliar ocorreu em três momentos: 30, 45 e 60 dias após a emergência (DAE) da cultura. Na associação B solo e foliar, a aplicação de B via solo foi feita usando sistema plante-aplique logo após o plantio. Aplicações foliares das doses de 500, 750 e 1.000 g ha-1 de B foliar, aumentam as porcentagens de germinação de plântulas normais. Portanto, a associação de B via solo e foliar nas doses de 250, 500, 750, 1.000 e 1.250 g ha-1 de B, resultam em porcentagens de germinação de plântulas normais com constância e superioridade a 88% e de plântulas anormais inferiores a 9%, quando comparado a aplicação somente via foliar, em solo com baixo conteúdo de B (<0,12 mg dm-3).
Virulência de fungos entomopatogênicos a Enneothrips flavens (Thysanoptera: Thripidae)
Authors: Ulhoa Lucas Adjuto , Rezende Gabriel Fernandes , Gomes Cintia de Melo , Pinto José Ricardo Lima , Polanczyk Ricardo Antonio 
Published: October 2020

A importância do Brasil como produtor de amendoim tem crescido nos últimos anos principalmente na produção de óleo vegetal e de subprodutos. Embora os produtores tenham adotado sistemas de produção mais eficientes, as perdas causadas por pragas têm sido um grande problema. Enneothrips flavens têm sido a principal praga do amendoim no Brasil. O controle de E. flavens tem sido realizado utilizando-se produtos químicos sintéticos. Objetivou-se com este trabalho avaliar a patogenicidade dos fungos Beauveria bassiana e Metarhizium anisopliae de produtos comerciais e da coleção da UNESP/FCAV sobre ninfas de E. flavens. Esporos destes fungos, na concentração de 108 mL-1 foram aplicados sobre o folíolo de plantas de amendoim contendo 10 ninfas de E. flavens. A mortalidade das ninfas foi avaliada após 3, 5 e 7 dias de observação. M. anisopliae (ARSEF 3293) e a cepa do produto comercial (Metarril®) apresentaram valores de mortalidade de 34% e 32%, respectivamente. A cepa B. bassiana do produto comercial (Boveril®) e a cepa B. bassiana (ARSEF 3288) apresentaram valores de mortalidade de 76% e 44%, respectivamente. Os dados obtidos neste trabalho sugerem que os isolados ARSEF 3293 e ARSEF 3288, assim como as cepas comerciais, têm potencial para serem usados como agente de controle biológico de E. flavens.
MOBILIDADE URBANA COMO DIREITO DE INCLUSÃO DAS PESSOAS COM DEFICIÊNCIA
Authors: Porfírio Mariana Silva , Sousa Ana Maria Viola de 
Published: October 2020

O fenômeno do acelerado crescimento das cidades tem provocado desordens no espaço urbano dificultando sobremaneira o deslocamento livre das pessoas com deficiência. Uma boa mobilidade urbana
é fundamental para identidade, experiência de vida e de oportunidades para todas as pessoas, mas muitas vezes, os impedimentos encontrados por pessoas com deficiência, constituem verdadeiro cerceamento de seus direitos, principalmente do seu direito de inclusão. Este trabalho tem por objetivo discutir e demonstrar que a livre mobilidade urbana das pessoas com deficiência é uma estratégia eficaz para promover seu direito de inclusão. Será utilizada a pesquisa bibliográfica e documental e abordagem teórico-doutrinária.
Reseach of the association of suicidal behavior and sleep disorders in persons with alcohol addiction
Authors: Efremov Ilya S. , Asadullin Azat R. , Nasyrova Regina F. , Akhmetova Elvina A. , Yuldashev Vladimir L. 
Published: October 2020

Thepurposeof the work is to determine the associations of sleep disorders and subjective perception of sleep quality with suicidal behavior and depressive manifestations in individuals with alcohol dependence.
Thefollowingmethodswere used a method of clinical interviewing, a psychodiagnostic method and the method of processing statistical data. We examined 128patients with chronic alcohol dependence (100men and 28women) aged 18 to 55years, the average age was 41.668.09 (median 41). There were used the following psychodiagnostic scales: ColumbiaSuicide Severity Rating Scale (PosnerK. et al., 2007); MontgomeryAsberg Depression Rating Scale (MADRS, MontgomeryS.A., AsbergM., 1979); The Pittsburgh Sleep Quality Index (PSQI, BuysseD.J. et al., 1989); Insomnia Severity Index (ISI, MorinS. et al., 2011). Statistical methods: ShapiroWilk test, MannWhitney U-test, Spearmans Rank correlation, KruskalWallis test, Pearsons chi-squared test.
Results.No correlation was found between the intensity of suicidal thoughts and sleep disturbances and sleep quality. People with suicidal ideation of insomnia have more pronounced insomnia. Associations were identified in the form of a direct correlation between sleep disorders and subjective sleep quality and the severity of depressive experiences.
Conclusions.It can be assumed that if there are any suicidal ideas regardless of the severity of these, insomnia is more pronounced. It may become an early criterion for diagnosing suicidal risk in the future. Sleep disturbances are associated with depressive symptoms and occur even when the clinical criteria for depressive disorder cannot be confirmed. Findings suggest the presence of more complex relationships of the described phenomena, which is planned to be studied in further clinical studies.
Real world efficacy of immunotherapy in nonsmall cell lung cancer
Authors: Moiseenko F. V. , Volkov N. M. , Abduloeva N. H. , Levchenko N. V. , Chubenko V. A. , Zhabina A. S. , Chernobrivceva V. V. , Shuginova T. N. , Shelekhova K. V. , Kheinshtein V. A. , Stepanova M. L. , Kramchaninov M. M. , Belukhin S. A. , Khabitcheva A. M. , Artemieva E. V. , Nosova M. V. , Tuleyko V. M. , Moiseyenko V. M. 
Published: October 2020

The evolution of drug therapy in solid tumors primarily leads to the increase in cancer specific survival, but inevitably raises financial burden. So far, none of the countries can venture total reimbursement with all necessary contemporary drugs for all patients. Doubling of expenses for cancer drug therapy in Russia in 2019 allowed oncologists using the most expensive treatments in more than 70 % of patients.Purpose: To evaluate efficacy of various treatment types of non‑small cell lung cancer in real clinical setting.Material and methods. We included patients with histologically verified metastatic non‑small cell lung cancer without activating mutations treated with first or second line therapy in 2018 – 2019. In total 287 patients were included: 230 — for the first line efficacy analysis, 100 — for the second. Time to disease progression, overall survival and objective response rate were evaluated.Results. The use of checkpoint inhibitors in accordance with all actual recommendations (first line pembrolizumab monotherapy in PD-L1 > 50 %, chemoimmunotherapy in first line or monotherapy in the second line irrespectively to PD-L1 status) decreased one‑year mortality from 61 % in 2018 to 33 % in 2019, but significantly increased financial cost (p < 0.000). Moreover, checkpoint inhibitors in combination with chemotherapy irrespectively of PD-L1 expression increased response rate (from 10 % and 21 % for monotherapy and platinum doublet, respectively, to 33,2 % for chemoimmunotherapy). PD‑1 inhibitors as monotherapy increased median time to disease progression (4,1 and 6,2 months for monotherapy with chemotherapy and platinum doublet, respectively, to 6,5 months and not achieved for chemoimmunotherapy and monotherapy with checkpoint inhibitors).Conclusion. More than doubling of financial costs spent for non‑small cell lung cancer treatment allowed access to contemporary treatment for all patients. Such unprecedented measures significantly improved efficacy, including double decrease of one‑year mortality. Nevertheless, rational design of regional clinical guidelines interpretation is of great importance in accurate and effective use of the healthcare budget.
Gender and age aspects of lung cancer incidence in a region with a developed petrochemical industry
Authors: Maksimov G. G. , Aznabaeva Yu. G. , Kirillova E. V. , Akhmetov V. M. 
Published: October 2020

The aim of the study is to study the gender-age aspects of the incidence according to the materials of the Republican Oncologic Dispensary.Methods. For the observation period from 2010 to 2017 the incidence of lung cancer in men is more common – in some cities from 2 to 7 times in different age groups.Results. For the first time, lung cancer in men and women is mainly recorded in the age group of 30 – 39 years. In other age groups, no clear gender-age dependence has been identified, in addition to the upward trend in morbidity rates in persons over 40 years.Conclusion. It was found that the reduction of emissions of different groups of carcinogens in the air in Ufa and Sterlitamak led to a decrease in the incidence of respectively 9.72 and 31.17%, and an increase in emissions in Salavat and Oktyabrsky increased by 6.53 and 18.33%.
Immunological skin tests in differential diagnostics disseminated processes in the lungs
Authors: Stogova N. A. 
Published: October 2020

Diseases that manifest as Х-ray syndrome of pulmonary dissemination are one of the most complex differential diagnostic problems in pulmonology and Phthisiology. Literature data on the effectiveness of using a new intradermal test with tuberculosis recombinant allergen (ATR, Diaskintest®) for disseminated processes in the lungs are single and contradictory.The aim. Тo study the diagnostic capabilities of intradermal test with tuberculosis recombinant allergen in disseminated lung processes of various etiologies.Methods. The analysis of archival materials of 204 patients with disseminated lung processes of various etiologies who were admitted to diagnostic departments of the N.S.Pokhvisneva Voronezh regional anti-tuberculosis dispensary in 2011 – 2019 was carried out. There were 85 (41.67%) women and 119 (58.33%) men aged 19 to 87 years. The data of im mu no - logical examination of patients using intradermal Mantoux samples with 2 TE PPD-L and with ATR were studied, and their comparative analysis was performed.Results. In disseminated pulmonary processes in tuberculosis, the proportion of individuals who respond positively to the Mantoux test was greater only in comparison with the group of people with sarcoidosis (p < 0.01) and did not significantly differ from the results in other groups of patients (p > 0.05). At the same time, the proportion of people who respond positively to a test with ATR in tuberculosis was greater than in patients with pneumonia, sarcoidosis (p < 0.01) and, to some extent, with a tumor. In healthy individuals, a lower proportion of positive reactions to ATR was established compared to the Mantoux test (p < 0.01). With active disseminated pulmonary tuberculosis, a hyperergic reaction (11.9%) was observed in the sample with ATR, which was not observed with the Mantoux test. In non-specific processes in the lungs, less often than negative reactions (p < 0.05) were detected on the sample with ATR less often than on the Mantoux test with 2 TE.Conclusion. The ATR sample compared to the Mantoux test indicates that it is appropriate to use it in the differential diagnosis of tuberculosis and non-specific lung diseases in adult patients with radiological dissemination syndrome.
Research on the Realization of Internal Audit Path for SMEs
Authors: Zhang Han 
Published: October 2020

<p>Compared with large enterprises such as state-owned enterprises, small and medium-sized enterprises pay far less attention to internal audit. Some small and medium-sized enterprises have a weak sense of internal audit, and some internal audit systems even exist in name only. After realizing the seriousness of this problem, researches that analyze small and medium-sized enterprises have find the SMEs internal audit, implementation path existing problems: the lack of independence of internal audit, the low comprehensive quality of internal audit personnel, the ineffective implementation of internal audit system, the backward auditing technology and methods, and solutions to problems are put forward.</p>
Research on Optimization of Financial Sharing Model Based on Blockchain Technology
Authors: Cheng Dong , Cheng Yu 
Published: October 2020

<p>The financial sharing model has gradually developed with the rise of group companies, but in the process of development, many problems such as unreasonable overall structure and centralized power have emerged. As a brand-new accounting information application technology, blockchain technology has the characteristics of distributed, decentralized, anti-counterfeiting and traceability, and it can be widely used in many fields. This article starts from the basic architecture of the blockchain, establishes an infrastructure model for the financial sharing model and a specific optimization path, and it finally designs an internal and external “dual chain” structure based on the financial sharing model under the blockchain technology, hoping to be a financial sharing model. The current development dilemma is looking for a new way out.</p>
Prophetic Parenting dalam Membentuk Akhlak Islami Anak Usia Dini pada Himpunan Wali Santri (HIWASI) RA Al Mansur Bulangan Haji Kecamatan Pegantenan Kabupaten Pamekasan
Authors: Karimah Kiswatul , Ummah MS S. Sumihatul 
Published: October 2020

Penelitian ini bertujuan untuk Mengetahui konsep implementasi, serta manfaat dari Prophetic Parenting dalam Membentuk Akhlak Islami Anak Usia Dini pada Himpunan Wali Santri RA Al Mansur Bulangan Haji Kecamatan Pegantenan Kabupaten Pamekasan.Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian deskriptif. Data yang diperoleh melelalui wawancara, observasi, dan dokumentasi, informannya yang dianggap menguasai bidang yang diteliti oleh peneliti adalah kepala sekolah, guru, ketua Himpunan wali santri dan wali santri. Sedangkan pengecekan keabsahan data melalui ketekunan, perpanjangan waktu dan trianggulasi.Hasil penelitian menunjukkan bahwa, pertama, konsep Prophetic Parenting dalam Membentuk Akhlak Islami Anak Usia Dini pada Himpunan Wali Santri RA Al Mansur yaitu dikonsep dengan beberapa materi kegiatan yang salaras dengan bagaimana Rasulullah SAW. mendidik anak yaitu melalui pembiasaan yang baik, penanaman kejujuran, pembiasaan berbahasa Madura halus, menjadi suri tauladan, pemberian perhatian dan kasih sayang, pemberian nasehat, sanjungan dan hukuman, membangun sosial kemasyarakatan anak serta membentuk aktivitas ibadah anak. Kedua, implementasi Prophetic Parenting yaitu terdapat pada program Parenting Class, Visiting Home, dan Perayaan Hari Besar Islam. Ketiga manfaat yang dirasakan oleh wali santri dan guru yaitu meningkatkan kesadaran orangtua tentang bagaimana mendidik anak dengan baik dan benar, wali santri bisa lebih memahami bagaimana cara mendidik anak yang mengacu pada bagaimana Rasulullah SAW. mendidik anak, wali santri mendapatkan informasi mengenai program pendidikan anak, silaturahmi, serta bisa mengetahui metode serta bagaimana menerapkan cara Nabi mendidik anak.
Optimization of Slotted Liner in Rubiales Field: Trade-Off between Sand Control, Flow Performance, and Plugging Tendency
Authors: Roostaei Morteza , Cespedes Edgar Alberto Mayorga , Uzcátegui Alberto A. , Soroush Mohammad , Hosseini Seyed Abolhassan , Izadi Hossein , Schroeder Brad , Mahmoudi Mahdi , Gomez Dionis M. , Mora Edgar , Alpire Javier , Torres Joselvis , Fattahpour Vahidoddin 
Published: October 2020

SummaryDesigning and selecting the proper sand control mechanism for horizontal wells in unconsolidated heavy-oil reservoirs tend to be underlooked in some cases. Standalone completions pose some sand control challenges, which could jeopardize the oil production or even lead to critical problems. Massive sand production, screen/formation plugging, hot spots, and mechanical integrity failures are some of the well-known issues. This study attempts to optimize the slotted liner design for horizontal wells in a heavy-oil field in Colombia.A careful selection of representative core data was made to study the variation of sand particle-size distribution (PSD) within the development area. Reservoir fluid properties were analyzed. Based on PSD variation and current design criteria in the industry, several seamed slotted-liner configurations were proposed as an alternative completion for testing. Later, a series of large-scale sand retention tests (SRTs) were performed to assess the selected alternatives under typical field production conditions. The effects of aperture size and open-to-flow area were investigated to evaluate flow and sand control performance.This investigation started with a detailed study of the PSD, particle shape variation, and composition of fines in the development area. The PSD then classified into four distinct minor and major sand facies, ranging from medium to very coarse sand with different fines content. Further investigations have shown that current design is only suitable for a limited number of the PSDs, while the overall PSD classes indicate the requirement for wider slot aperture sizes. The results of the SRTs indicated that the flow performance of the screen is mainly controlled by the slot aperture. Choosing the optimized aperture size avoids unacceptable sanding even for the multiphase flow scenarios with gas. Results also indicated that by increasing the aperture size and application of the seamed slots for the studied formation, plugging could be mitigated.A comprehensive sand control design workflow for cold primary heavy-oil production in horizontal wells is presented in this work. The current study is one of the first that investigates and compares conventional straight slotted liners with seamed slotted liners at a larger scale for this field. Moreover, this study helps to better understand the effect of design parameters of seamed slotted liners on sand control, flow performance, and plugging tendency.
Socio-demographic and clinical characteristics of diabetes mellitus in rural Rwanda: Time to contextualize the interventions? A cross-sectional study
Authors: Munganyinka Charlotte Bavuma , Musafiri Sanctus , Rutayisire Pierre-Claver , Ng’ang’a Loise M , McQuillan Ruth , Wild Sarah H. 
Published: October 2020

Abstract
Background: Existing prevention and treatment strategies target the classic types of diabetes yet this approach might not always be appropriate in some settings where atypical phenotypes exist. This study aims to assess the socio-demographic and clinical characteristics of people with diabetes in rural Rwanda compared to those of urban dwellers.Methods: A cross-sectional, clinic-based study was conducted in which individuals with diabetes mellitus were consecutively recruited from April 2015 to April 2016. Demographic and clinical data were collected from patient interviews, medical files and physical examinations. Chi-square tests and T-tests were used to compare proportions and means between rural and urban residents.Results: A total of 472 participants were recruited (mean age 40.2±19.1years), including 295 women and 315 rural residents. Compared to urban residents, rural residents had lower levels of education, were more likely to be employed in low-income work and to have limited access to running water and electricity. Diabetes was diagnosed at a younger age in rural residents (mean ± SD 32±18 vs 41±17 years; p < 0.001). Physical inactivity, family history of diabetes and obesity were significantly less prevalent in rural than in urban individuals (44% vs 66%, 14.9% vs 28.7% and 27.6% vs 54.1%, respectively; p < 0.001). The frequency of fruit and vegetable consumption was lower in rural than in urban participants. High waist circumference was more prevalent in urban than in rural women and men (75.3% vs 45.5% and 30% vs 6%, respectively; p< 0.001). History of childhood under-nutrition was more frequent in rural than in urban individuals (22.5% vs 6.4%; p< 0.001).Conclusions: Characteristics of people with diabetes in rural Rwanda appear to differ from those of individuals with diabetes in urban settings, suggesting that sub-types of diabetes exist in Rwanda. Generic guidelines for diabetes prevention and management may not be appropriate in different populations.
53 Years Old is A Reasonable Cut-Off Value To Define Young And Old Patients In Clear Cell Renal Cell Carcinoma：A Study Based On TCGA And SEER Database
Authors: Tang Fucai , Lu Zechao , He Chengwu , Zhang Hanbin , Wu Weijia , He Zhaohui 
Published: October 2020

Abstract
Background: The objectives of this study were to screen out cut-off age value and age-related differentially expressed genes (DEGs) in clear cell renal cell carcinoma (CCRCC) from Surveillance Epidemiology and End Results (SEER) database and The Cancer Genome Atlas (TCGA) database. Methods: We selected 45,974 CCRCC patients from SEER and 530 RNA-seq data from TCGA database. The age cut-off value was defined using the X-tile program. Propensity score matching (PSM) was used to balance the differences between young and old groups. Hazard ratio (HR) was applied to evaluate prognostic risk of age in different subgroups. Age-related DEGs were identified via RNA-seq data. Survival analysis was used to assess the relationship between DEGs and prognosis.Results: In this study, we divided the patients into young (n=14276) and old (n=31698) subgroups according to cut-off value (age=53). Age >53 years was indicated as independent risk factor for overall survival (OS) and cancer specific survival (CSS) of CCRCC before and after PSM. The prognosis of old group was worse than that in young group. Eleven gene were differential expression between the younger and older groups in CCRCC. The expression levels of PLA2G2A and SIX2 were related to prognosis of the elderly. Conclusion: 53 years old was cut-off value in CCRCC. The prognosis of the elderly was worse than young people. It remind clinicians that more attention and better treatment should be given to CCRCC patients who are over 53 years old. PLA2G2A and SIX2 were age-related differential genes which might play an important role in the poor prognosis of elderly CCRCC patients.