bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 Worries and Behavior Changes in Older and Younger Men and Women
Authors: Barber Sarah J , Kim Hyunji 
Published: May 2020

Abstract

Objectives
The case fatality rate of coronavirus disease 2019 (COVID-19) is higher among older adults than younger adults and is also higher among men than women. However, worry, which is a key motivator of behavioral health changes, occurs less frequently for older than younger adults, and less frequently for men than women. Building on this, we tested whether older adults–and particularly older men—would report the least amount of COVID-19 worry and also fewer COVID-19 behavior changes.

Method
From March 23–31, 2020, we administered an online questionnaire assessing COVID-19 perceptions, worries, and behavior changes. Participants were a convenience sample of U.S. residents, who were community-dwelling younger adults (18–35) or older adults (65–81). Analyses included 146 younger adults (68 men, 78 women) and 156 older adults (82 men, 74 women). Participants were predominately white, living in suburban/urban areas, and had completed some college.

Results
During the early phase of the outbreak in the United States, older adults perceived the risks of COVID-19 to be higher than did younger adults. Despite this, older men were comparatively less worried about COVID-19 than their younger counterparts. Compared with the other participants, older men had also implemented the fewest behavior changes.

Discussion
Interventions are needed to increase COVID-19 behavior changes in older men. These results also highlight the importance of understanding emotional responses to COVID-19, as these are predictive of their behavioral responses.
Effect of Moisture on Efficacy of Selected Insecticide Dusts Against the Common Bed Bug,Cimex lectularius(Hemiptera: Cimicidae)
Authors: Ranabhat Sabita , Wang Changlu 
Published: May 2020

AbstractInsecticide dust formulations are considered as more effective for controlling the common bed bug, Cimex lectularius (L) (Hemiptera: Cimicidae), than residual sprays. Various environmental factors may affect the efficacy of insecticide dusts. In this study, we evaluated the effect of moisture on the efficacy of three insecticide dusts against C. lectularius. Moisture was created using two methods: applying steam to insecticide dust-treated tiles and aging insecticide dust-treated tiles in chambers with various levels of relative humidity (RH). In the steam treatment, three insecticides including Cimexa (92.1% amorphous silica gel), Alpine (0.25% dinotefuran, 95% diatomaceous earth), and Tempo (1% cyfluthrin) were evaluated. Exposure to steam significantly reduced the efficacy of all three insecticide dusts. Among the three insecticides, the efficacy of Cimexa was significantly higher than Alpine and Tempo. In the different RH treatments, Cimexa treated tiles that were aged under different (52, 75, and 100%) RH conditions for 1 and 2 mo caused significantly lower mortality to C. lectularius than nonaged Cimexa. We conclude that both, a short period of exposure to steam and long-period aging in a moist environment, can significantly reduce the efficacy of insecticide dusts. Moisture needs to be considered when applying insecticide dusts for controlling bed bug infestations.
Linac-based fractionated stereotactic radiotherapy with a micro-multileaf collimator for large brain metastasis unsuitable for surgical resection
Authors: Matsuda Ryosuke , Tamamoto Tetsuro , Sugimoto Tadashi , Hontsu Shigeto , Yamaki Kaori , Miura Sachiko , Takeshima Yasuhiro , Tamura Kentaro , Yamada Shuichi , Nishimura Fumihiko , Nakagawa Ichiro , Motoyama Yasushi , Park Young-Su , Nakase Hiroyuki , Hasegawa Masatoshi 
Published: May 2020

Abstract
The aim of this study was to assess clinical outcomes using linac-based, fractionated, stereotactic radiotherapy (fSRT) with a micro-multileaf collimator for large brain metastasis (LBM) unsuitable for surgical resection. Between January 2009 and October 2018 we treated 21 patients with LBM using linac-based fSRT. LBM was defined as a tumor with ≥30 mm maximal diameter in gadolinium-enhanced magnetic resonance images. LBMs originated from the lung (n = 17, 81%), ovary (n = 2, 9.5%), rectum (n = 1, 4.8%) and esophagus (n = 1, 4.8%). The median pretreatment Karnofsky performance status was 50 (range: 50–80). Recursive partition analysis (RPA) was as follows: Classes 2 and 3 were 7 and 14 patients, respectively. The median follow-up was 5 months (range: 1–86 months). The range of tumor volume was 8.7–26.5 cm3 (median: 17.1 cm3). All patients were basically treated with 35Gy in 5 fractions, except in three cases. The progression-free survival was 3.0 months. The median survival time was 7.0 months. There was no permanent radiation injury in any of the patients. Radiation-caused central nervous system necrosis, according to the Common Terminology Criteria for Adverse Events version 4.0, occurred in one patient (grade 3). One patients received bevacizumab for radiation necrosis. Two patients underwent additional surgical resection due to local progression and cyst formation. For patients with LBM unsuitable for surgical resection, linac-based fSRT is a promising therapeutic alternative.
Protective Effects of Obstructive Sleep Apnea on Outcomes After Subarachnoid Hemorrhage: A Nationwide Analysis
Authors: Kaculini Christian , Wallace David J , Haywood Audrey E , Michalek Joel , Mascitelli Justin , Seifi Ali , Grandhi Ramesh 
Published: May 2020

Abstract

BACKGROUND
Obstructive sleep apnea (OSA) is typically associated with an increased risk of cardiovascular and cerebrovascular disease. Recent studies, however, have suggested that hypercapnia and chronic intermittent hypoxia may potentially provide protection against ischemic events like stroke.

OBJECTIVE
To evaluate the impact of OSA with presentation, hospital course, and treatment outcomes of patients with subarachnoid hemorrhage (SAH).

METHODS
Data for patients with SAH between the years 2011 and 2015 were extracted from the Nationwide Inpatient Sample (NIS) and stratified based on diagnosis codes for OSA. Univariate analysis was used to assess the prevalence of comorbidities in OSA patients diagnosed with SAH and several covariates, including patient demographics, aneurysmal treatment, in-hospital morality rate, length of stay, and costs. Multivariate logistic regression models analyzed the relationship between several comorbidities, including OSA, tobacco use, and hypertension, and poor outcomes after SAH.

RESULTS
Data from 49 265 SAH patients were used in this study, of which 2408 (4.9%) also had a concomitant OSA diagnosis. Patients with OSA compared to all other SAH patients had a significantly lower in-hospital mortality rate, as well as statistically significant lower odds of vasospasm, stroke, and poor outcomes. Additionally, hypercholesterolemia, obesity, and tobacco use disorder were also associated with more favorable outcomes.

CONCLUSION
SAH patients with OSA are significantly less likely to have a poor outcome when compared to non-OSA patients, despite having an increased risk of several comorbidities.
Best Buys and Own Brands: Investment Platforms’ Recommendations of Mutual Funds
Authors: Cookson Gordon , Jenkinson Tim , Jones Howard , Martinez Jose Vicente 
Published: May 2020

Abstract
Individuals increasingly buy mutual funds via online platforms, whose “best-buy” recommendations heavily influence flows. As intermediaries of mutual funds, platforms provide none of the unobservable interaction or intangible benefits of brokers, and so allow clean tests of the determinants, influence, and value of their fund recommendations. Using unique U.K. data, we find that platforms favor “own-brand” funds and those paying them a higher commission share. Investors discount own-brand recommendations, but not those paying high commission shares (which were not observable in the United Kingdom). A regulatory ban on commission sharing lowered costs and improved the informativeness of platform recommendations.
Winners, Losers, and Regulators in a Derivatives Market Bubble
Authors: Li Xindan , Subrahmanyam Avanidhar , Yang Xuewei 
Published: May 2020

Abstract
We use proprietary brokerage data to study trading patterns within a well-known financial market bubble: the Chinese warrants bubble. Persistently successful investors trade very actively and exhibit characteristics of de facto market makers. Unskilled investors unprofitably trend-chase and increase holdings in out-of-the-money warrants near expiration, whereas sophisticated investors do the reverse. We find that regulators did not properly forecast trading frenzies, as the prespecified price limits often exclude the fundamental values of warrants.
Effects of QDs exposure on the reproductive and embryonic developmental toxicity in mice at various pregnancy stages
Authors: Chen Ling , Zheng Fengxia , Yang Pengfei , Chen Bolu , Aguilar Zoraida P , Fu Fen , Xu Hengyi 
Published: May 2020

Abstract
Quantum dots (QDs) have recently attracted considerable attention in the biomedical fields because of their unique and excellent optical properties. However, information on their health effects, particularly in the reproductive system, is limited. The present study focuses on the effects of intravenous injection of CdSe/ZnS QDs on the reproductive system and embryo development at various stages of pregnancy in mice. The CdSe/ZnS QDs intravenously injected in mice during pregnancy accumulated in the maternal liver, uterus and placenta. This accumulation affected the growth and development of the embryo during the early and middle stages of pregnancy. Moreover, genotoxicity to the placenta after exposure to CdSe/ZnS QDs was demonstrated by the increased expression levels of genes related to oxidative stress and apoptosis and the reduced expression levels of genes related to the nutrient and waste transportation. Alterations in the gene expression levels have hindered the transport of metabolites across the placenta, which in turn affected the ability of the fetus to obtain nutrients.
Cost-effectiveness of newer regimens for the prophylaxis of chemotherapy-induced nausea and vomiting: review of the literature and real-world data
Authors: Giuliani Jacopo , Bonetti Andrea 
Published: May 2020

Purpose of review
To investigate the cost of netupitant and palonosetron (NEPA) in the prophylaxis of chemotherapy-induced nausea and vomiting (CINV) in adults receiving highly emetogenic chemotherapy (HEC) and moderately emetogenic chemotherapy (MEC) for cancer treatment in real life.

Recent findings
A retrospective analysis of all consecutives patients with advanced lung cancer treated in platinum-based (carboplatin or cisplatin) chemotherapy and with breast cancer treated with anthracycline and cyclophosphamide -based chemotherapy at our Medical Oncology Unit during 4 years was performed. The costs of drugs are at the Pharmacy of our Hospital (€).

Summary
We evaluated 110 patients with lung cancer and 55 patients with breast cancer. Concerning lung cancer, we have obtained an advantage of 133 € in monthly medical costs of NEPA and dexamethasone (DEX) vs. the combination of palonosetron (PALO) and DEX for each patient. Concerning breast cancer, we have obtained an advantage of 78 € in monthly medical costs of NEPA and DEX vs. the combination of PALO and DEX for each patient. Combining the medical costs of antiemetic therapy with the measure of efficacy represented by the complete response, the combination of NEPA and DEX is cost-effective for preventing CINV in HEC and MEC cancer treatment.
Peer-Review and Rejection Causes in Submitting Original Medical Manuscripts
Authors: Mendiola Pastrana Indira Rocío , Hernández Adriana Vargas , Pérez Manjarrez Francia Estefanía , López Eduardo Ortiz , Romero-Henríquez Luisa Fernanda , López-Ortiz Geovani 
Published: May 2020

Abstract:
The purpose of specialized medical journals is to accurately disseminate the results of new research. The peer-review process is crucial for journals to be able to fulfill this purpose. Although the peer-review determines whether scientific papers are accepted or rejected for publication, for many authors is a not well known process in its entirety. Many journals have focused on educating their audience about how and what is assessed during peer-review, nevertheless, the rate of manuscripts rejected because of easily-avoidable causes related to this, remains high. In this paper, we describe the process that specialized journals use to assess original medical manuscripts and list the main causes of paper rejection. Practicing physicians and medical students who wish to report their research results stand to benefit if they can identify and early avoid on the issues that most often arise during the peer-review process.
A Case for Early Screening: Prenatal Alcohol Risk Exposure Predicts Risk for Early Childhood Communication Delays
Authors: Netelenbos Nicole , Sanders James Ladell , Ofori Dei Samuel , McDonald Sheila 
Published: May 2020

ABSTRACT:

Objective:
Studies have confirmed the detrimental effects of prenatal alcohol exposure on language development in children. Little is known about the ability of prenatal alcohol risk (PAR) screening measures to predict language or other neurodevelopmental delays in young children, however. The intent of this study is to identify whether PAR predicts communication development in children at 12, 24, and 36 months of age.

Method:
Data from 772 women and their children who participated in the All Our Families pregnancy cohort were analyzed. Respondents completed the T-ACE, a validated screening tool for detecting PAR. Communication development in children was measured through the Ages and Stages Questionnaire, Third Edition. Logistic regression was used to generate odds ratios and 95% confidence intervals.

Results:
A positive screen for PAR places a child at risk for communication delay (≤1 SD below mean) by approximately 1.5-fold at 12, 24, and 36 months of age, even after adjustment for demographic variables. Follow-up analysis revealed a significant difference in the prevalence of risk for communication delays between 12 and 24 months and between 24 and 36 months in both low- and high-risk drinking groups, with 24-month-old children showing the greatest risk for delay.

Conclusion:
The results of this study suggest that screening for PAR in expectant mothers may identify a group of young children at increased risk for communication delays. This research carries clinical implications and provides support for PAR screening in informing early childhood developmental screening efforts.
Subarachnoid block and ultrasound-guided transversalis fascia plane block for caesarean section
Authors: Aydin Muhammed E. , Bedir Zehra , Yayik Ahmet M. , Celik Erkan C. , Ates İrem , Ahiskalioglu Elif O. , Ahiskalioglu Ali 
Published: May 2020

BACKGROUND
After caesarean section, maternal postoperative comfort is critical to allow the new mother to care for her baby. Insufficient pain relief during the postoperative period may delay maternal/infant bonding and, in addition, such pain has been linked to subsequent depression and chronic pain. Caesarean section is commonly performed with a Pfannenstiel incision, and a transversalis fascia plane (TFP) block provides postoperative analgesia in the T12 and L1 dermatomes.

OBJECTIVE
The aim of this study was to investigate the effect of the TFP block on postoperative opioid consumption and pain scores in patients undergoing caesarean section under spinal anaesthesia.

DESIGN
A randomised controlled, double-blind study.

SETTINGS
Single-centre, academic hospital.

PARTICIPANTS
Sixty patients undergoing caesarean section.

INTERVENTIONS
The TFP group (n = 30) received an ultrasound-guided bilateral TFP block with 20 ml of 0.25% bupivacaine. The control group (n = 30) received 20 ml of saline bilaterally. Postoperative analgesia was given every 6 h with intravenous paracetamol 1 g and patient-controlled analgesia (PCA) with morphine.

MAIN OUTCOME MEASURES
Postoperative visual analogue pain scores, morphine consumption, rescue analgesia and opioid-related side effects were evaluated.

RESULTS
In the TFP group, the visual analogue pain scores were significantly lower at rest for 2 h after the operation (P = 0.011) and during active movement at 2, 4 and 8 h postoperatively (P = 0.014, <0.001 and 0.032, respectively). Morphine consumption in the first 24 h after surgery was significantly higher in the control group compared with the TFP group (38.5 ± 11.63 and 19.5 ± 8.33 mg, respectively; P < 0.001). The incidence of postoperative nausea and constipation were statistically higher in the control group than in the TFP group (P < 0.05). Patient satisfaction was significantly higher in the TFP group (P = 0.027).

CONCLUSION
A postoperative TFP block can reduce opioid consumption and relieve acute pain after a caesarean section under spinal anaesthesia.

TRIAL REGISTRATION
ClinicalTrials.gov, NCT04172727.
Omega-3 fatty acid therapy for cardiovascular disease: justified or not?
Authors: Maki Kevin C. , Dicklin Mary R. 
Published: May 2020

Purpose of review
To discuss the current evidence regarding the relationship between omega-3 fatty acid intake and atherosclerotic cardiovascular disease (ASCVD) risk.

Recent findings
Combined results from randomized controlled trials using low-dosage (≤1.8 g/day of ethyl esters) eicosapentaenoic acid (EPA) or EPA + docosahexaenoic acid (DHA) suggest a small benefit for reducing coronary heart disease risk. The Reduction of Cardiovascular Events with EPA-Intervention Trial (REDUCE-IT) that administered 4 g/day icosapent ethyl (IPE) to individuals on statin at high or very high ASCVD risk with elevated triglycerides demonstrated a 25% relative risk reduction in the composite primary endpoint (cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, coronary revascularization and unstable angina) for IPE vs. placebo, and a lower hazard for all prespecified individual endpoints other than total mortality. Several national organizations have recommended IPE for ASCVD risk reduction in populations aligning with REDUCE-IT; the Food and Drug Administration has approved IPE for ASCVD risk reduction. However, the Outcomes Study to Assess Statin Residual Risk Reduction with Epanova (EPA + DHA carboxylic acids) in High Cardiovascular Risk Patients with Hypertriglyceridemia was recently stopped for futility.

Summary
At present, the best available evidence for a role of omega-3 fatty acids in ASCVD risk reduction is for 4 g/day of IPE, as an adjunct to statin therapy, for patients with ASCVD or diabetes mellitus and elevated triglycerides.
Blood pressure measurements on a bare arm, over a sleeve or below a rolled-up sleeve: a systematic review and meta-analysis
Authors: Seguret David , Gamelon Danaé , Dourmap Caroline , Steichen Olivier 
Published: May 2020

Objective:
Several guidelines call for blood pressure (BP) measurement on a bare arm, which is not always easy. This systematic review aims to synthesize existing evidence concerning the effect of a sleeve on BP measurement.

Methods:
Pubmed and Embase were searched for cross-sectional studies comparing BP values measured on a bare arm, over a sleeve or below a rolled-up sleeve. A meta-analysis was conducted on available data.

Results:
Thirteen articles were selected from 720 references. All studies reported office BP values, 12 compared measurements on a bare arm and on a sleeve, and four also performed measurements below a rolled-up sleeve, with heterogeneous sleeve types and thicknesses. Most studies had a high risk of bias. Three studies showed a small overestimation of BP measured over a sleeve, but the remaining 10 studies did not find statistically significant differences between measurements. Meta-analysis showed a nonsignificant 0.59 mmHg [95% confidence interval (CI) −0.11 to +1.30; P = 0.10] overestimation of SBP measured over a sleeve when the thinnest sleeve was considered for studies that investigated various thicknesses, a nonsignificant 1.10 mmHg (95% CI −0.21 to +2.40; P = 0.10) overestimation of SBP when the thickest sleeve was considered, and a nonsignificant 2.76 mmHg (95% CI −0.96 to +6.47; P = 0.15) overestimation of SBP measured below a rolled-up sleeve.

Conclusion:
Measuring BP over a thick sleeve in the office may result in a small overestimation of recorded values but measuring over a thin sleeve does not appear to have a significant impact and, in any case, should be preferred to rolling it up.
Refractive surgery for the patient with autoimmune diseases
Authors: Chen Tony Y. , Chu David S. 
Published: May 2020

Purpose of review
Autoimmune and immune-mediated diseases are considered contraindications for laser refractive surgeries according to the US Food and Drug Administration's guideline. This guideline, however, is based on limited case reports or complications reported during other intraocular procedures. There have been only a handful of new clinical studies that evaluate the efficacy and safety of refractive surgery in this specific patient population. The aim of this article is to review currently available research and offer updated recommendations for the evaluation and management of laser refractive surgery (LRS) in patients with autoimmune diseases.

Recent findings
More recent retrospective studies have reported good refractive outcomes in patients with well controlled autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, seronegative spondyloarthropathy, among others. No severe sight-threatening complications have been reported in these reports. Although postoperative complications occur, the risk of refractive surgery is comparable with those without autoimmune diseases.

Summary
With the exception of primary Sjogren's syndrome, patients with autoimmune diseases may be good candidates for LRS if diseases are well controlled and have minimal ophthalmic manifestation. Patients should be made aware of the potential surgical complications and be informed of the currently available data. More multicenter and larger prospective studies are needed to compare the refractive outcomes and surgical complications in patients with and without autoimmune diseases. This will help patients make better informed medical decisions.
Preoperative carbohydrates: what is new?
Authors: Gianotti Luca , Sandini Marta , Hackert Thilo 
Published: May 2020

Purpose of review
The aim of this review is to give an overview of recently published articles covering preoperative carbohydrate loading in surgical patients.

Recent findings
Between January 1, 2017, and December 31, 2019, 26 publications addressing the effect of carbohydrate load were retrieved through a systematic search. Seventeen were randomized clinical trials, three prospective observational studies and six retrospective series with case-control comparison. Most of the studies were underpowered, addressed surrogate endpoints, and variability among dose and timing of carbohydrate (CHO) treatment was high. The most recent literature endorses preoperative carbohydrate loading up to 2 h before operations as a safe treatment. The new evidence confirm that this strategy is effective in reducing perioperative insulin resistance and the proportion of hyperglycemia episodes, and improving patient well-being and comfort but without affecting surgery-related morbidity.

Summary
Further properly designed randomized clinical trials, addressing more clinically relevant endpoints such as length of hospitalization and morbidity rate, are warrant.