bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urokinase Plasminogen Activator Overexpression Reverses Established Lung Fibrosis
Authors: Horowitz Jeffrey C. , Tschumperlin Daniel J. , Kim Kevin K. , Osterholzer John J. , Subbotina Natalya , Ajayi Iyabode O. , Teitz-Tennenbaum Seagal , Virk Ammara , Dotson Megan , Liu Fei , Sicard Delphine , Jia Shijing , Sisson Thomas H. 
Published: November 2019

Abstract
Introduction Impaired plasminogen activation (PA) is causally related to the development of lung fibrosis. Prior studies demonstrate that enhanced PA in the lung limits the severity of scarring following injury and in vitro studies indicate that PA promotes matrix degradation and fibroblast apoptosis. These findings led us to hypothesize that increased PA in an in vivo model would enhance the resolution of established lung fibrosis in conjunction with increased myofibroblast apoptosis.
Methods Transgenic C57BL/6 mice with doxycycline inducible lung-specific urokinase plasminogen activator (uPA) expression or littermate controls were treated (day 0) with bleomycin or saline. Doxycycline was initiated on days 1, 9, 14, or 21. Lung fibrosis, stiffness, apoptosis, epithelial barrier integrity, and inflammation were assessed.
Results Protection from fibrosis with uPA upregulation from day 1 through day 28 was associated with reduced parenchymal stiffness as determined by atomic force microscopy. Initiation of uPA expression beginning in the late inflammatory or the early fibrotic phase reduced stiffness and fibrosis at day 28. Induction of uPA activity in mice with established fibrosis decreased lung collagen and lung stiffness while increasing myofibroblast apoptosis. Upregulation of uPA did not alter lung inflammation but was associated with improved epithelial cell homeostasis.
Conclusion Restoring intrapulmonary PA activity diminishes lung fibrogenesis and enhances the resolution of established lung fibrosis. This PA-mediated resolution is associated with increased myofibroblast apoptosis and improved epithelial cell homeostasis. These studies support the potential capacity of the lung to resolve existing scar in murine models.
Pseudo-Cerebrospinal Fluid Leaks of the Anterior Skull Base: Algorithm for Diagnosis and Management
Authors: Constanzo Felipe , Pinto Jaime , Sedaghat Sahba , Schmidt Thomas 
Published: November 2019

Abstract
Objective Pseudo-cerebrospinal fluid (CSF) leaks are a rare cause of unilateral, watery rhinorrhea. We proposed a step-wise approach to evaluate these cases.
Design It involves a single-center retrospective cohort study.
Setting The setting is that of a tertiary academic medical center.
Participants Ten patients with diagnosis of pseudo-CSF leak over a 21-year period were evaluated using our proposed algorithm that includes computed tomography, magnetic resonance imaging, nasal endoscopy, β-2 transferrin, intrathecal fluorescein, and surgical exploration of the anterior cranial base.
Main Outcome Measures The occurrence of intracranial infection and resolution of the symptoms were evaluated at a mean follow-up of 94.4 months.
Results Eight patients had history of skull base fracture or surgery. In all patients computed tomography, magnetic resonance imaging, and nasal endoscopy did not show signs of CSF leak. Beta-2 transferrin testing was performed in five patients, being negative in all of them. Intrathecal fluorescein was performed in seven patients, being negative in five and inconclusive in two. Surgical exploration was performed in five patients, definitively ruling out CSF leak. Six patients were treated with intranasal ipratropium, resolving the symptoms in all cases.
Conclusion The presented algorithm provides a step-wise approach for patients with unilateral watery rhinorrhea, allowing to safely ruling out CSF leak.
Algorithms for i-optimal designs for ordinal response: a literature approach
Authors: Hamim Wigena Aji , Erfiani  , Mohamad Soleh Agus , Dyah Syafitri Utami 
Published: November 2019

AbstractIn many cases, the reseachers face the problem how to design the experiment which deal with the real situation. This is because the designs on literature do not suit the case. To solve the problem, optimal design can be an alternative. There are two approaches on optimal design: an analytical and a computational approach. An algorithm in the computational approach is needed to find an optimal design. The optimal design is a part of experimental design which seeks the design based on a certain criterion. The criterion which focuses on presicion of prediction variance is I-optimality criterion. Limited literatures address the I- optimality criterion for ordinal response. Most of literatures address to developing algorithms of other optimality criteria for General Linear Model. As the response is ordinal, hence the ordinal response belongs to non-linear model.
Value of perfect information in stock picking
Authors: Rosha Media 
Published: November 2019

Abstract
Portfolio picking is an important aspect in investmtent management. Before deciding what stock to pick, an investor will consider many aspect of the stock, the fundamental and the trend of the market. Knowing what to expect is an important science and art in investment. Expected value of perfect information – EVPI is the difference between two payoff that predicted to be the best of some certain condition. For portfolio management, we could employ Capital Asset Pricing Model to provide clearer view of each securities and using treynor ratio to optimize the investment result. Description in this paper about performance analysis of stocks in LQ-45 index in Indonesian Stock Index in 1-st quartil period of 2015, based on return and risk to reach the group of stocks which optimum using the model of Capital Asset Pricing Model (CAPM). Our finding suggests that using CAPM and Treynor Ratio analysis could optimize the portfolio outcome, while changing business and economic environment create limitation on the portfolio.
Fuzzy c-means and gath-geva methods in clustering districts based on human development index (hdi) in south sulawesi
Authors: Annas S , Nyompa S , Arisandi R , Nusrang M , Eka S 
Published: November 2019

Abstract
District grouping in South Sulawesi based on the Human Development Index (HDI) indicators needs to be done as a material for planning and evaluating the targets of government work programs. This grouping is based on dominant indicators of the high and low HDI. The value of the HDI indicator needs to be considered so that the achievement of each indicator is known. Statistical analysis that can be used to group districts that have similarities is cluster analysis. The method that is currently developing is fuzzy clustering analysis, which classifies objects using certain membership degrees. Fuzzy clustering algorithm that can be used is Fuzzy C-means (FCM). Another method of fuzzy clustering analysis developed further is Gath Geva (GG), which is able to detect groups with different forms. In this study, the fuzzy clustering process on the FCM and GG methods with the same parameters and shows that the GG method is better than the FCM method. This conclusion is based on a total of 1000 iterations. The GG method gives an objective function value smaller than FCM, besides it gives a faster- conferencing iteration result.
An analysis of the relevancy between mathematics and productive subject in computer and network engineering program at vocational high school
Authors: Silvia Wahyuni , Armiati  
Published: November 2019

Abstract
The fast development of science and technology and the workforce competition in this globalization era, require education academy to produce a competent and good quality of human resources in their field. Vocational high school is an education academy that is expected to create professional and productive human resources to fulfil every skill pursuit that is needed in the workforce.Computer and network engineering program and mathematics have a role in science and technology development and in the workforce competition.Productive subject in computer and network engineering will produce productive and professional graduates that can compete in the workforce.Since the activity that include mathematics could develop logical reasoning, logical thinking, systematic, critical, neat and objective, mathematics could help computer and network engineering graduates in solving the problem in the workforce. This paper will deliver the relevancy between mathematics and productive subject in computer and network engineering program at vocational high school.
D-optimal design for ordinal responses in mixture experiments
Authors: Rahayu W D , Syafitri U D , Soleh A M 
Published: November 2019

AbstractA mixture experiment is an experiment in which the response depends on the ingredients proportions. In organoleptic test, the response is ordinal. This research focused on how to generate the D-optimal design of ordinal response. The model belongs to Generalized Linear Model (GLM) with logit as the link function. To find the D-optimal design which is seeking the design that minimizing the covariance of parameter model, the point-exchange algorithm was constructed. There were three ingredients of a cookies recipe which were needed to mix meanwhile other ingredients were fixed. The D-optimal design of the three ingredients consisted of seven design points.
Inventory model of goods availability with apriori algorithm
Authors: Husna Radhiatul , Lestari Riri , Hendra Yomei 
Published: November 2019

Abstract
In this study, mathematical modeling will be discussed to determine the probabilityof goods purchase based on other goods. Research on this topic is considered to be important and interesting to study because it describes the implementation of applied mathematics by constructing a mathematical model and solving it using an apriori algorithm related to the application of the probability concept. In this case, the apriori algorithm is used to determine the pattern of dependency relationships between goods and other goods so that the probabilityof goods purchase based on other goods can be found. To get the output of this research which is in the form of the mathematical modeling for determining the probability of goods being purchased depended on the purchase of other goods, then selecting and classifying the types of goods based on the sales, using the apriori algorithm, constructing models, finding a solution of models and interpreting of the model are conducted.
Optimal reinsurance based on compound Poisson distribution
Authors: Chadidjah Anna , Noviyanti Lienda , Zanbar Soleh Achmad 
Published: November 2019

Abstract
BPJS Kesehatan (BPJS-Health) is a public agency for health, established to implement the social security program. The health insurance prepared through BPJS is in the form health protection for participants to get health care benefits and protection to meet the basic needs of health care. It is provided to every person who has paid fees or whose contributions are paid by the government. Claims estimation in BPJS-Health is required to increase the optimal service to participants. Imprecision in determining such estimates could destabilize the BPJS-Health. In this research, estimated total health service claims submitted by partnered health facility to BPJS based on Buhlmann-Straub Credibility. We also use the compound Poisson distribution to illustrate the optimal retentions in a collective risk model.
Optimal reinsurance using the expected shortfall
Authors: Noviyanti Lienda , Zanbar Soleh Achmad , Chadidjah Anna 
Published: November 2019

Abstract
The Financial Services Authority Regulation regarding Self-Retention and Domestic Reinsurance Support (Otoritas Jasa Keuangan / OJK Regulation) was issued to establish a more comprehensive framework concerning self-retention and reinsurance support of insurance companies. Insurance Companies must implement and maintain a self-retention limit based on their risk and loss profile. This requires Insurance Companies to make available a certain amount of capital for every risk that they undertake. Insurance companies must develop and implement a reinsurance support strategy to ensure that they have sufficient capacity to meet their liabilities. In this research, we estimate the optimal retention by means of Expected Shortfall which will minimize the risk of individual total based on the quota share reinsurance. We use lognormal bivariate distribution to illustrate the optimal retention in an individual risk model.
Synthesis of silver nanoparticles used chemical reduction method by glucose as reducing agent
Authors: Eka Putri Gusliani , Rahayu Gusti Feni , Novita Sary Annisa , Zainul Rahadian 
Published: November 2019

Abstract
Silver nanoparticles have been successfully synthesized using a chemical reduction method at room temperature using glucose as a reducing agent, silver nitrate as a source of nitrate, polyvinyl alcohol (PVA) as a stabilizing agent. The purpose of this research was to determine the effect of the mole ratio of reducing agent Glu / Ag and percentage (%) PVA (b/v) in the silver nanoparticle synthesis of the resulted product. Product characterization was analyzed by UV-Vis Spectrophotometers, XRD, and TEM. The Analysis of the UV-Vis spectra showed that the most stable particles were silver nanoparticles used PVA 3% and Glu / Ag. 1: 8 on λmax 415 to 417 nm. TEM’s characterization showed that silver nanoparticles were spherical with a dominant size range of 12,28 nm – 38,45 nm nm. The newly synthesized silver nanoparticles may have a potential for antibacterial applications.
Preparation of dye sensitized solar cell (DSSC) using isolated anthocyanin fromfruit sat (melastomamalabathricum l) dicopimented with salicylic acid as dye
Authors: Hardeli  , Indra A , Rahadian  
Published: November 2019

Abstract
A study has been conducted on the use of anthocyanin extract from fruits (Melastomamalabthricum L), which was incubated by the addition of salicylic acid as photosensitizer in DSSC solar cells. The objective of this study was to determine the optimum condition of the extracts of copigmenation which resulted in the optimum efficiency of DSSC solar cells by increasing the absorption ability of anthocyanin pigment photons.The method used is the method of copigmentation. Copigmentation is an anthocyanin reaction with a copigment compound to form a more complex anthocyanin structure with a number of double bonds that can absorb more photons than the original anthocyanin.. The results of dye characterization using UV-Vis and FTIR indicate a wider absorption spectrum and a more complex structure in antigianated anthocyanins when compared without copigmentation. Based on the results of the characterization of the prepared TiO2 thin film, obtained crystal size of TiO2 used ranged from 27.377 to 64.738 nm with a width of200-950 nm photocathode spekrum absorption. Based on the results of the research, it is found that the antiganant extract can be increased by DSSC solar cell efficiency from 0.62% to 1.32% with 24 hours of copigmentation time and 1: 2 concentration of concentration.
Preparation and characterization of thin film CoFe2O4/Zn/CoFe2O4 by using spin-coating method
Authors: Sanjaya Hary , Oktavia Budhi , Lasdeni Sadri Lira , Ramli  
Published: November 2019

Abstract
Research has been conducted on the manufacture of CoFe2O4 / Zn/CoFe2O4 thin films using sol gel-spin coating method. This study aims to look at the effect of rotational speed on optical properties and electrical properties, and to find the highest GMR ratio. Making CoFe2O4 uses Co2+ precursors and Fe2+ precursors with a mole ratio of 1: 2, dissolved with ethyl alcohol. The Zn precursor was made with a concentration of 0.5 M from Powder (CH3COO)2Zn. 2H2O dissolved with ethyl alcohol. The rotation speed variations used are at 2000 rpm, 2500 rpm, 3000 rpm, 3500 rpm and 4000 rpm. The thin layer of GMR is made with a sandwich structure. CoFe2O4/Zn/CoFe2O4 thin films with variations in rotational speed were tested for electrical properties using the 4-point probe system method and characterized using X-Ray Diffraction, Scanning Electron Microscopy (SEM), and UV-Vis Specrophotometer. Based on the testing of the electrical properties obtained the lowest resistance and resistivity values at 2000 rpm rotation speed, where the faster the rotational speed is used, the greater the resistance and resistivity values. The highest GMR ratio obtained was 53.5%. Measurement results with Scanning Electron Microscopy (SEM) obtained layer thickness of 3.5 μm.
Amino acid and mineral composition of moringa oleivera leaves extract and its bioactivity as antioxidant
Authors: Natsir H , Wahab A W , Budi P , Dali S , Arif A R 
Published: November 2019

Abstract
Moringa leaf (Moringaoleifera) is a plant that grows in Indonesia with high nutritional content. This plant has biological activity as antidiabetic, blood pressure-lowering, and antioxidant. This study analyzes the nutritional content of Moringa leaf extract, especially amino acids, minerals and determines its antioxidant. Analysis of total amino acid content has been carried out by HPLC (High performance liquid chromatography) method, minerals with ICP-OES (Inductive coupled plasma-optical emission spectroscopy) and antioxidant activity by DPPH (1,1-diphenyl-2-picrylhydrazyl) method. The analysis of Moringa leaf extract has obtained 15 kinds of amino acids, namely: threonine (9403.09), lysine (11694.16), leucine (18087.41), isoleucine (9321.59), phenylalanine (17236.01), valine (11183.48), methionine (5684.68), tryptophan (2577.82) while non-essential amino acids include histidine (9965.39), proline (10068.07), tyrosine (8641.63), aspartate acid (16585.76), glycine (13027.13), arginine (13123.94), alanine (14474.52), glutamate acid (30106.87), serine (10055.98), cysteine (470.37) in ppm. The analysis of minerals has obtained 13 essential minerals included Al, Ca, Co, Cr, Cu, Fe, K, Mg, Mn, Ni, P, Se, Zn. The highest mineral is shown for selenium (1097.84 ppm) and chrome (919.99 ppm) at the second highest order. Sodium (68.83 ppm) and magnesium (60.84 ppm) is found as minerals with low concentrations. The antioxidant test has shown weakness activity with an average IC50 value of 9.901 μg/mL, using ascorbic acid as a positive control with IC50 values of 196.892 μg/mL. The analysis results of amino acids, minerals, and antioxidant activity show that Moringa leaves are very potential for human nutrients.
Synthesis and characterisation of a partially methylated dodecyl thiomaltotrioside derivative as a precursor of cyclodextrin analogue
Authors: Parbuntari H , Sakairi N , Purwono B , Swasono R T 
Published: November 2019

AbstractDue to the enermous roles of cyclodextrin combining with small organic molecules, more recent interests study about the manipulation of cyclodextrin structure giving better performance for any kinds of field but they presented long synthetis steps as producing the precursors. This study points out the synthesis of precursor of β-cyclodextrin analouges with maltotriose as raw materials giving the short synthesis steps. The product structures were analysed by Fourier Transform Infrared (FTIR) Specstroscopy,and characterised by1H-,13C- NMR, COSY NMR, and ESI Mass Spectroscopy. The result showed thatO-acetylation reaction produced maltotriose derivative 1 (95%), thioglycosidation reaction produced maltotriose derivative 2 (54%), de-acetylation reaction produced maltotriose derivative 3 (97%),O-benzylidation reaction produced a mixture of maltotriose derivatives 4,O- methylation reaction produced maltotriose derivative 5 (46%) and de-benzylidation reaction produced maltotriose derivative 6 (85%).
Distribution and sources of polycyclic aromatic hydrocarbon (PAH) on sediment around makassar coast
Authors: Syahrir Muhammad 
Published: November 2019

Abstract
This study conducts an analysis related to distribution and source of PAH in sediment around Makassar coast. Sediment sample has been taken up using Van Veen grab and put in a plastic sac, brought to laboratory, added with salt, stored in dried freezer, and followed for PAH analysis. Sample preparation has been carried out using DCM and n-hexane (1:1) solvent to obtain extract of organic matter (EOM). The EOM is fractionated to yield alkane fraction (F1) and aromatic fraction (F2) containing PAH. The GC-FID has been used to determine PAH concentration through analysis of F2. Validation of the analytical method applies linearity, LoD, and LoQ. The recovery test has fulfilled for all PAH compounds except for naphthalene and fluoranthene. The highest concentration of PAHs is found at station 7 with benzo(a)antracene 933.23±3.88 ppm and perylene 205.75±19.45 ppm. The lowest total concentration of PAHs is found at station 12 located at the estuary of Tello River caused by dilution from both river and sea water. The source of PAHs in sediment is generally from petrogenic and pirolytic process.
Synthesis hydroxyapatite/collagen/chitosan composite for tissue engineering
Authors: Cahyaningrum S E , Herdyastuti N , Puspita F W , Devina B , Kurniasari M 
Published: November 2019

Abstract
Hydroxyapatie/Collagen/Chitosan composite has been synthesized by ex-situ methods. The purpose of this research is to study the composition’s effect of the composite HA/Coll/Chi to some characters such as a functional group and phase as well as the physical character such as crystallinity, the compressive strength and surface morphology. HA synthesized from the precursor calcium derived from duck eggshell reacted with H3PO4, HA sintered at 900 °C. HA was added with collagen and chitosan solutin with a mass ratio of the composition HA/Coll/Chi are 7: 2: 1; 7: 1,5: 1,5; 7: 1: 2. FTIR analysis showed a band PO4
3−and OH− adsorption of HA, as well as a shift vibration of spectra in the group C = O and NH2 from chitosan and collagen that shows there has been a bond between collagen, chitosan and HA. Data of XRD showed that the phase of HA and chitosan in the composite of HA/Coll/Chi. Composite with collagen component hight has low cristalinity.
Immunostimulant activity of steroid compound from the indonesian silver fern (P. calomelanos)
Authors: Sutoyo S , Ismono  , Mitarlis  , Hidajati N , Rinaningsih  
Published: November 2019

Abstract
A secondary metabolite in steroid compound, namely β-sitosterol had been isolated from the n-hexane extract of the Indonesian silver fern. Extraction was conducted by maceration method, separation by chromatography techniques (vacuum liquid chromatography and flash chromatography), purification by recrystallization, and identification of its molecular structure by the spectroscopic methods and by comparison with reported literature data. The steroid isolate was yielded as colorless amorphous powder (melting point of 136– 137 °C). Based on the carbon clearance method, isolated steroid showed immunostimulant activity with phagocytosis index of 1.625.
Characterization Membrane Composition Of PVA-Enzyme Coating PVC-KTpClPB As Urea Sensor With UV-VIS, SEM-EDX and XRD
Authors: Abd Hakim S , Tarigan Krista , Situmorang Manihar , Sembiring Timbangen 
Published: November 2019

Abstract
Potentiometrie ion sensor (ISE) is very attractive because of its small size, easy to carry, more durable, and miniature easy to use. ISE consists of an indicator electrode and a reference electrode located in an electrolyte solution. Potentiometric electrodes and electrochemical properties can be achieved through membrane synthesis and selectivity by the interaction of primary ions with respect to cavity size, molecular geometry and types of functional groups leading to the interaction between electrolyte solutions, membranes and indicator electrodes with reference electrodes. Indicator electrodes function as urea analytes. Potentiometric characteristics are significantly dependent on the composition of the membrane, the nature of the plasticizers. Characterization of membrane composition was carried out using (UV-Vis, SEM-EDX, and XRD). Characterization of PVA membrane : PVC in the composition of 1 : 1 of 0.0350 g PVA and plasticizer 0.0700 g KTpClPB variation of membrane electrode layer and enzyme 1 mg. The optimum amount of diffraction intensity is obtained from PVA E 4X PVC-KTpClPB 0.0700.