bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimasi Metode KCKT untuk Penetapan Kadar 4-Isobutilasetofenon dan 2-(4-Isobutirilfenil) Asam Propanoat dalam Tablet Ibuprofen
Authors: Chrissanti Rara Dyah , Darmawati Asri , Yuwono Mochammad 
Published: June 2020

Pendahuluan: Ibuprofen (IBP) banyak digunakan sebagai obat anti piretik dan pereda nyeri, obat ini sensitif terhadap oksidasi dan suhu. Cemaran IBP yang keberadaannya dalam tablet harus memenuhi syarat uji batas adalah 4-isobutilasetofenon (IBP RC C) dan 2-(4-isobutirilfenil) asam propanoat (IBP RC J). Variasi matriks tablet seringkali membuat prosedur standar untuk analisis cemaran perlu dioptimasi karena dapat menyebabkan kinerja kromatografi yang tidak memenuhi syarat kompendia. Tujuan: Penelitian ini bertujuan untuk memperoleh kolom dan kondisi operasional KCKT yang selektif, efisien dan memenuhi persyaratan kompendia untuk pengujian IBP dan cemarannya. Metode: Penelitian ini dirancang untuk membandingkan kinerja kromatografi (resolusi, faktor ikutan dan jumlah lempeng teoritis) beberapa kolom KCKT C18 yang sesuai persyaratan United States Pharmacopoeia (USP) untuk penetapan cemaran organik dalam tablet ibuprofen. Instrumen KCKT yang digunakan adalah Shimadzu Prominence dengan detektor Photo Diode Array (PDA). Kondisi analisis optimum yang diperoleh diaplikasikan untuk analisis 3 macam sediaan tablet IBP. Hasil: Kondisi optimum diperoleh melalui kolom C18-C 4,6 x 250 mm, 5 µm, menggunakan fase gerak larutan asam kloroasetat 1% pH 3,0 : asetonitril (45:55, v/v), laju alir 1,5 mL/menit, suhu kolom ambient, detektor PDA 254 nm, volume injeksi 10 µL dengan waktu analisis 11 menit. Diperoleh puncak-puncak yang simetris dengan kinerja kromatografi yang memenuhi persyaratan USP. Kesimpulan: Metode yang telah dioptimasi berhasil diaplikasikan pada 3 sediaan tablet yang beredar di pasaran dan dapat digunakan untuk pengujian rutin dalam rangka pengawasan kualitas produk obat tablet ibuprofen.
Validated TLC-Contact Bioautography Method for Identification of Kanamycin Sulfate in Injection Preparation
Authors: Susanti Susanti , Dwiana Aprelita Nurelli , Annuryanti Febri , Darmawati Asri , Isnaeni Isnaeni 
Published: June 2020

Background: TLC-contact bioautography is one of an effective method for identification antibiotics, by which many antibiotics could be identification and determination simultaneously. Objective: To evaluate kanamycin sulfate in injection preparations based on its inhibitory activity against Escherichia coli ATCC 8739 as test organism. Methods: Sample and standard solutions were spotted onto TLC silica gel 60 F254 plate and developed in 10% potassium dihydrogen phosphate solutionas as mobile phase. The TLC-contact bioautography method was validated according to USP guidelines by considering specificity, LOD, LOQ, linearity, accuracy and precision parameters. Results: The TLC-contact bioautography method was found to be high sensitivity with LOD of 0.75 µg and LOQ 2.31 µg. Linearity range of 100-350 µg/mL with r = 0.9993 and linear regression equation was y = 0.0019x + 0.0338. The recovery obtained from addition of blank samples by three different concentrations of kanamycin sulfate standard was 101.40% ¬+ 2.02%. The precision of the method was good with coefficient of variation 0.080%. The TLC-contact bioautography method was supported by determination of kanamycin sulfate potency ratio in the injection preparation and kanamycin sulfate standard using 3-3 design. Random block design obtained the potential for kanamycin sulfate in injection preparations compared to kanamycin sulfate standard was 100.6%. Conclusion: The TLC-contact bioautography for kanamycin sulfate in injection preparations could be applied to the quality control analysis of the investigated drugs.
PEMBERDAYAAN KARANG TARUNA DALAM MENDUKUNG GERAKAN PSN 3M PLUS : UPAYA PENGENDALIAN DEMAN BERDARAH DENGUE DI DESA BARUREJO KECAMATAN SAMBENG KABUPATEN LAMONGAN
Authors: Qona'ah Arina , Hidayati Laily , Bakar Abu 
Published: June 2020

Pendahuluan: Lamongan merupakan salah satu daerah di Jawa Timur yang mengalami KLB (Kejadian Luar Biasa) untuk kasus DBD (Demam Berdarah Dengue). Pengendalian DBD dapat dilakukan melalui upaya promotof dan preventif. Tujuan pengabdian masyarakat ini adalah membentuk kelompok masyarakat yang berperan dalam pengendalian DBD serta meningkatkan pengetahuan dan keterampilan masyarakat terkait pencegahan dan penanganan DBD.Metode: Kegiatan pengabdian masyarakat dilakukan menggunakan metode ceramah, diskusi, dan demonstrasi. Pengabdian masyarakat dilakukan pada kelompok pemuda karang taruna dan warga masyarakat yang tinggal di Desa Barurejo Kabupaten Lamongan. Jumlah pemuda karang taruna yang terlibat adalah 30 orang sedangkan warga masyarakat sebanyak 50 orang. Pendidikan dan pelatihan yang diberikan menggunakan media audio visual dan alat peraga. Evaluasi pelatihan dengan menggunakan kuosioner yang diberikan di awal dan akhir kegiatan. Adapun bentuk kegiatan pengabdian masyarakat yang diberikan meliputi pembentukan Juru Pemantau Jentik (Jumantik), pelatihan cara melakukan pemantauan jentik, penyuluhan kesehatan tentang Deman Berdarah Dengue dan cara pencegahannya serta penanaman tanaman pengusir nyamuk.Hasil: Kegiatan pengabdian masyarakat ini telah membentuk juru pemantau jentik yang berasal dari unsur karang taruna. Tim jumantik diberikan penyuluhan dan pelatihan tentang jumantik. Hasil evaluasi menunjukkan bahwa sebagian peserta memiliki tingkat pengetahuan yang tinggi mengenai jumantik dan mampu untuk melakukan pemantauan jentik nyamuk. Kesimpulan: Pemuda karang dapat menjadi kelompok masyarakat yang berperan dalam mengendalikan demam berdarah melalui Gerakan PSN 3M Plus. Pembentukan Jumantik dan pelatihan pemantaun jentik serta penyuluhan kepada masyarakat mengenai demam berdarah memberikan dampak dalam peningkatan kesadaran dan pengetahuan masyarakat dalam pencegahan demam berdarah.
Diplomasi Indonesia Berbasis Program Cross Border Tourism dalam Meningkatkan Kunjungan Wisatawan Mancanegara
Authors: Elyta Elyta , Nuzulian Ully 
Published: June 2020

Aruk Sajingan Indonesia telah menghadapi tantangan tentang minimnya kunjungan wisatawan mancanegara, hal ini dikarenakan aruk termasuk pintu masuk darat yang hanya mendapatkan no urut keempat dari lima pintu masuk darat yang ada di Indonesia., sebagai upaya meningkatkan kunjungan wisatawan manca negara melalui pintu masuk darat maka Indonesia melakukan diplomasi melalui program cross border tourism. Berdasarkan hal tersebut maka penelitian ini bertujuan untuk menganalisa implementasi diplomasi Indonesia berbasis program cross border tourism dalam meningkatkan kunjungan wisatawan mancanegara batas di wilayah border Aruk Sajingan Kabupaten Sambas Kalimantan Barat Indonesia. Peneliti menggunakan metode kualitatif, teknik pengumpulan data dengan menggunakan teknik wawancara teknik observasi dan teknik dokumentasi. Hasil penelitian teranalisa Implementasi diplomasi Indonesia berbasis program cross border tourism dalam meningkatkan kunjungan wisatawan mancanegara di wilayah border Aruk Sajingan Kabupaten Sambas Kalimantan Barat Indonesia telah dilakukan oleh multi track diplomacy yaitu government; bussiness; dan private citizent. Implementasi diplomasi melalui government berlandaskan pada tiga tingkatan regulasi yaitu tingkatan lokal, nasional dan internasional. Lebih lanjut implementasi diplomasi melalui Bussines dilakukan oleh The Indonesian Tours and Travel Agencies (Asita) dan dioperasikannya pasar belampar yang berlokasi dekat dengan Pos Lintas Batas Negara (PLBN) Aruk Indonesia, Asita selaku pelaku bisnis telah mempromosikan daya tarik wisata yang dimiliki desa di Aruk Sajingan dan telah mengajak para wisatawan mancanegara untuk berbelanja di pasar belampar. Implementasi Diplomasi melalui private citizent dilakukan oleh komunitas Generasi Pesona Indonesia (GenPI) dan Generasi Wonderful Indonesia (GenWI) dengan menyebarkan potensi cross-border tourism melalui media digital. Dengan demikian multi track diplomacy telah menyebabkan wisatawan mancanegara tertarik berkunjung ke perbatasan Aruk Indonesia, hal tersebut menyebabkan meningkatnya sektor pariwisata lintas batas.
KUALITAS PERMEN JELLY SARI BUAH PEPAYA (Carica papaya L.) DENGAN PENAMBAHAN EKSTRAK KELOPAK BUNGA ROSELLA (Hibiscus sabdariffa L.)
Authors: Adriana Livia , Pranata Franciscus Sinung , Swasti Yuliana Reni 
Published: June 2020

Jelly candy is a favorite snack of various ages from children to adults because it has an attractive color, delicious aroma and taste, and a chewy texture. In this study, papaya juice (Carica papaya L.) was used as a base ingredient for making jelly candy because papaya is a fruit that is very easy to find and has a relatively cheap price. In order to improve the quality of the papaya jelly candy, roselle calyx extract (Hibiscus sabdariffa L.) was also added. Roselle calyx has been known to have high antioxidants because they contain anthocyanin pigments. The purpose of this study was to determine the effect of variations in the addition of roselle calyx extract to the papaya jelly candy. The experimental design in this study was a completely randomized design with variations in the addition of roselle calyx extract by 0% (control), 15%, 30%, and 45%. The parameters tested in this study include chemical, physical, microbiological, and organoleptic qualities. The results of the research that have been carried out show the addition of 45% roselle calyx extract can produce the best papaya jelly candy based on water content, total titrated acid, antioxidant activity, total anthocyanin, texture, color, and microbiological tests which include total plate count and numbers of yeast molds.
Keywords : jelly candy, papaya juice, roselle calyx extract
PENGAJUAN DAN PEMBERIAN HAK RESTITUSI BAGI ANAK YANG MENJADI KORBAN KEJAHATAN SEKSUAL
Authors: Prihatmini Sapti , Tanuwijaya Fanny , Wildana Dina Tsalist , Ilham Misbahul 
Published: June 2020

This paper aims to analyze the mechanism for submitting and granting restitution as the responsibility of perpetrators of crimes. This is to fulfill the rights of children who are victims of criminal acts. The implemented provisions governing the submission and granting of restitution are regulated in PP No. 44 of 2008 and PP No. 43 of 2017. However, the implementation of the restitution provision,which is the right of the child (victim), has not been fully implemented due to a lack of maximum assistance by the relevant government, such us fulfilling the rights of victims to obtain rehabilitation, compensation and restitution as a form of protection of children after the occurrence of a crime for the loss suffered by the child and / or the family of the victim. This study uses doctrinal research (doctrinal legal research), while the approach used is (socio-legal studies) an effort to explore a problem by not only fulfilling the study of legal norms or doctrines, but also looking comprehensively at the context of norms and enforcement. The results showed that the submission of restitution stipulated in Government Regulation No. 43 of 2017 outlines that restitution is a compensation payment charged to the perpetrator based on a court decision. It has permanent legal force for material and immaterial losses suffered by the victim or his family, as in the case of giving restitution for a non specifically regulated the period of payment and a rejection of payments from perpetrators of sexual crimes.
PENGGOLONGAN PENDUDUK DALAM PEMBUATAN SURAT KETERANGAN WARIS TERKAIT PENDAFTARAN HAK ATAS TANAH SETELAH BERLAKUNYA UNDANG-UNDANG NOMOR 12 TAHUN 2006 TENTANG KEWARGANEGARAAN REPUBLIK INDONESIA
Authors: Sari Ketut Novita , Sihabudin Sihabudin , Sutjito Bambang 
Published: June 2020

This research aims at analyzing the classification of citizen in the making of statement of inheritance related to the registration of right over land after the enactment of Law number 12 year 2006 about the Republic of Indonesia citizenship. It also analyzes the legal force of statement of inheritance issued by notary, statement of inheritance issued by Village chief of the head of the district, and the statement of inheritance issued by Balai Harta Peninggalan (the office of inheritance affairs) related to the registration of right over land after the enactment of Law number 12 year 2006 2006 about the Republic of Indonesia citizenship. This research is normative using statute, conceptual, and historical approaches. Data analysis employed Grammatical and historical interpretations The findings of the study show that citizen classification in the making of statement of inheritance still applies as the regulation has not yet been repealed. Regulation for specific group of citizen should not imperatively apply. Whwn the rule is repealed, the regulation becomes alternative of facultative for the citizens of Indonesia. The legal force of statement of inheritance couses problems because the regulation regarding the form of the document is no clear so that it does not qualify to be a perfect evidence.
Estrategias, posiciones y prácticas científicas en la enseñanza y la Investigación de la Comunicación en América Latina | Strategies, positions and scientific practices in teaching and research of the Communication in Latin America
Authors: León Duarte Gustavo Adolfo 
Published: June 2020

ResumenEl documento muestra un avance del protocolo de investigación titulado “la constitución científica de la investigación latinoamericana en comunicación. Una aproximación a las características estructurales de la producción científica del Pensamiento Latinoamericano de la Comunicación (PLC) 1997-2010”, el cual es financiado por el Programa de Mejoramiento del Profesorado de la Secretaría de Educación Pública de México y la Universidad de Sonora (www.uson.mx). Particularmente, expone algunas de las características de hondo arraigo que buscan enfatizar cuáles son y en qué consisten las estrategias, posiciones y prácticas científicas en los principales colectivos científicos que hoy en día encarnan a la investigación latinoamericana en Comunicación: por un lado, con respecto a la producción científica generada por la llamada Escuela Latinoamericana de la Comunicación (ELACOM). Por otro, con respecto a la producción científica que simboliza a la Asociación Latinoamericana de Investigadores de la Comunicación (ALAIC). Finalmente, se analizan las estrategias, posiciones y prácticas científicas divulgan algunas de las más destacadas revistas latinoamericanas de la comunicación.Palabras claveInvestigación de la Comunicación, Ética de la Comunicación, Epistemología, Transdisciplina. ResumoEste artigo mostra algumas das características estruturais que procuram enfatizar quais são e em que consistem as principais perspectivas e posições epistemológicas interdisciplinarias no coletivo cientista da chamada Associação Latinoamericana de Pesquisadores da Comunicação (ALAIC). Também algumas de suas principais distinções com os aportes que por separado geram duas fontes de investigação em comunicação que são a estas datas transcendentais no campo de estudos da comunicação em Latinoamérica: por um lado, com respeito à produção científica gerada pela Escola Latinoamericana da Comunicação (ELACOM). Por outro, com respeito à produção científica que divulgam algumas das mais marcantes revistas latinoamericanas da Comunicação.Palavras-ChaveInterdisciplina, Investigação da Comunicação, Epistemologia, transdisciplina.AbstractThe document shows some of the structural features that seek to emphasize what they are and what the major interdisciplinary perspectives and epistemological positions in the Latin American Communication Researchers. Also some of their main distinctions with the contributions of two important sources in the field of communication studies in Latin America: on one hand, with regard to scientific output generated by the scientific community of the so-called Latin American School of Communication. For other one, with regard to the scientific production that there spread some of the most prominent Latin American journals of CommunicationKey WordsInterdisciplinary, Communication Research, Epistemology, Cross-discipline.
A Virtual Reality based intervention for surgical patients: study protocol of a randomized controlled trial
Authors: Georgescu Raluca , Dobrean Anca , Silaghi Cristina Alina , Silaghi Horațiu 
Published: June 2020

Abstract
Background: Pain after surgery is normal, and treatments, including both pharmacological and psychological components, are fundamental for proper postoperative care. While several trials have investigated the analgesic effect of traditional non-pharmacological treatments, such as Cognitive Behaviors Therapies, the newer ways of delivering psychological interventions for pain after surgery are scarcely investigated. The aim of this randomized controlled trial (RCT) is to determine if delivering the psychological content through Virtual Reality (VR) along with the standard pharmacological treatment return better pain relief outcomes than standard care in adult patients following surgery. Methods: This is a protocol of a parallel RCT conducted in one community hospital. In order to test the efficacy of VR environments for reducing pain intensity, in the following day after surgery, adults (18 to 65 years) will be randomly assigned to either (1) standard treatment after surgery (control group) or (2) VR based intervention along with standard treatment. It is intended that a minimum of 30 patients be recruited in each group. For estimating the intensity of pain, both self-report and physiological measures will be used. Repeated measures of pain outcomes will be taken before and after the intervention. Moreover, for allowing an in-depth investigation of the effect of VR environments, the primary outcome will be complemented with measures of the adverse effects, level of immersion, and level of presence in the VR environment.
Analysis of exosomal circRNAs upon irradiation in pancreatic cancer cell repopulation
Authors: Chen Yi-yun , Jiang Ming-jie , Chen Zhi-long , Tian Ling 
Published: June 2020

Abstract
Background: Pancreatic cancer is one of the most malignant tumors. However, radiotherapy can lead to tumor recurrence, which is caused by the residual surviving cells repopulation stimulated by some molecular released from dying cells. Exosomes may mediate cell-cell communication and transfer kinds of signals from the dying cells to the surviving cells for stimulating tumor repopulation. Circular RNAs (circRNAs) may be one vital kind of exosomal cargos involving in modulating cancer cell repopulation. Methods: Next generation sequencing (NGS) and bioinformatics were performed to analyze and annotate the expression and function of exosome-derived circRNAs in pancreatic cancer cells after radiation. 4 circRNAs were chosen for qRT-PCR analysis to validate the sequencing results. Results: In this study, 3,580 circRNAs were annotated in literatures and circBase among 12,572 identified circRNAs. There were 196 filtered differentially expressed circRNAs (the up-regulation and down-regulation respectively is 182 and 14, fold change >2, p-value <0.05). Regulation of metabolic process and lysine degradation were the main enriched biological processes and pathway according to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Conclusions: The hsa_circ_0002130-hsa_miR_4482-3p-NBN interaction network suggested potential sponging miRNA and target mRNA. Our results provided potential functions of circRNAs to explore molecular mechanisms and therapeutic targets in pancreatic cancer cell repopulation upon irradiation.
Premature Mortality of Gastrointestinal Cancer in Iran: Trends and Projections for 2001–2030
Authors: Shadmani Fatemeh Khosravi , Farzadfar Farshad , Yoosefi Moein , Mansori Kamyar , Shadman Reza Khosravi , Haghdoost Ali Akbar 
Published: June 2020

Abstract
Background: The present study was conducted to determine the trend and projection of premature mortality from gastrointestinal cancers (GI cancers) at national and subnational levels in Iran.Methods: Employing the data obtained from Iranian Death Registry System (DRS) and population data from census, the mortality rates of GI cancers was calculated among 30-70 age groups. The trends of esophageal, colon and rectum, gallbladder, pancreases, stomach, and liver cancer premature mortalities were estimated and projected at the national and subnational levels from 2001 to 2030. Then, Spatio-temporal model was used to project spatial and temporal correlations. Results: The overall mortality rate of GI cancers was higher in males than in females, indicating 6.1, 3.9 and 3.9 percent per 100000 individuals among males in 2001, 2015 and 2030 respectively and 3.8, 3.1 and 3.7 per 100000 individuals among females in the same time-frame. The overall mortality rate of GI cancers in males was decreasing until 2015 and will remain stationary into 2030; however, the rate will be increasing among females in both time-frames. Also, there was a considerable variation in the mortality trends of different cancers. Pancreatic, gallbladder, and liver cancers were shown to have an increasing trend while a drop was observed in the mortality rates of stomach, colon and rectum, and esophageal cancers. Conclusion: Variation of GI cancers patterns and trends around the country indicated that a more comprehensive control plan is needed to include the predicted variations.
Seasonal Variation in the Occurrence of Retinal Vein Occlusion: A 4-Year Cross-sectional Study
Authors: Matsuzawa Moe , Sakanishi Yoshihito , Ebihara Nobuyuki 
Published: June 2020

Abstract
Background: Retinal vein occlusion (RVO) is a common retinal vascular disease that causes a loss of vision. Therefore, we investigated whether there is seasonal variation in the onset of RVO, to examine the possibility of preventing it.Methods: Patients with RVO who were treated at the Juntendo University Urayasu Hospital between April 2013 and March 2017 were included in this retrospective study. The season in which the RVO occurred was recorded for each case, and the cases were grouped into six 2-month periods based on the month of RVO, and classified by age, sex and hypertension status. The frequency of occurrence of RVO across seasons was compared using a chi-squared test.Results: A total of 348 patients with RVO presented during the study period, with information regarding the date of RVO onset. The cohort of 348 consisted of 167 males and 181 females who, overall, had a mean age of 64.0 years (range 17–96 years). The highest incidence of RVO onset was during January/February, with the lowest incidence during July/August. Patient age, sex and hypertension status did not influence the results.Conclusions: The seasonal onset of RVO tended to be higher in January/February and May/June, and lower in July/August. These findings suggest that eyecare professionals should be more vigilant in watching for the occurrence of RVO during winter and the rainy season, regardless of the patient’s sex, age or hypertension status.