bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association and Linkage Mapping to Unravel Genetic Architecture of Phenology-Related Traits and Lateral Bearing in Persian Walnut (Juglans regia L.)
Authors: Bernard Anthony , Marrano Annarita , Donkpegan Armel , Brown Patrick J. , Leslie Charles A. , Neale David B. , Lheureux Fabrice , Dirlewanger Elisabeth 
Published: December 2019

Abstract
Background: Unravelling the genetic architecture of agronomic traits in walnut such as budbreak date and bearing habit, is crucial for climate change adaptation and yield improvement. A Genome-Wide Association Study (GWAS) using multi-locus models was conducted in a panel of 170 walnut accessions genotyped using the Axiom™ J. regia 700K SNP array, with phenological data from several years. These accessions come from the INRAE walnut germplasm collection which is the result of important prospecting work performed in many countries around the world. In parallel, an F1 progeny of 78 individuals segregating for phenology-related traits, was genotyped with the same array and phenotyped for the same traits, to construct linkage maps and perform Quantitative Trait Loci (QTLs) detection. Results: Using GWAS, we found strong associations of SNPs located at the beginning of chromosome 1 with both budbreak and female flowering dates. These findings were supported by QTLs detected in the same genomic region. Highly significant associated SNPs were also detected using GWAS for heterodichogamy and lateral bearing habit, both on chromosome 11. We developed a Kompetitive Allele Specific PCR (KASP) marker for budbreak date in walnut, and validated it using plant material from the Walnut Improvement Program of the University of California, Davis, demonstrating its effectiveness for marker-assisted selection in Persian walnut. We found several candidate genes involved in flowering events in walnut, including a gene related to heterodichogamy encoding a sugar catabolism enzyme and a cell division related gene linked to female flowering date. Conclusions: This study enhances knowledge of the genetic architecture of important agronomic traits related to male and female flowering processes and lateral bearing in walnut. The new marker available for budbreak date, the first key trait for good fruiting, will facilitate the selection and development of new walnut cultivars suitable for specific climates.
Patients' satisfaction factors mining and sentiment analysis of B2C mail-order pharmacy reviews
Authors: Liu Jingfang , Zhou Yingyi , Jiang Xiaoyan , Zhang Wei 
Published: December 2019

Abstract
BackgroundIn recent years, mail-order pharmacies have been accepted by increasingly more patients, and the prospects for mail-order pharmacies are optimistic. This article explores the patients’ satisfaction factors addressed in Business to Customer (B2C) mail-order pharmacy reviews and analyzes the sentiments expressed in the reviews. The goal of this work is to help B2C mail-order pharmacy enterprises identify patients’ concerns, continuously improve the health services level.MethodsThis paper was based on the Latent Dirichlet Allocation (LDA) topic model. From a B2C mail-order pharmacy of integrated e-commerce and a vertical B2C mail-order pharmacy (JD.COM and J1.COM, respectively), 136,630 pieces of over-the-counter (OTC) drug review data posted from January 1, 2015 to December 31, 2018 were selected as samples and used to explore the satisfaction factors of B2C mail-order pharmacy patients regarding the entire drug purchasing process. Then, the sentiments expressed in the drug reviews were analyzed with SnowNLP.ResultCategorization of the 12 factors identified by LDA showed that 5 factors were related to logistics; these 5 factors, which also included the most drug reviews, made up 38.5% of the reviews. The number of factors related to drug prices was second, with 3 factors, and reviews of drug prices made up 25.5% of the reviews. Customer service and drug effects each had two related factors, and a smaller percentage of these reviews (13.95%) were related to drug effects. Patients still maintain positive opinions of JD.COM and J1.COM. However, some opinions on logistics and drug prices are expressed.Conclusion The most important task for mail-order pharmacies is to improve logistics. It is better to develop self-built logistics. Both types of B2C mail-order pharmacies can improve patient viscosity by implementing marketing strategies. With regard to customer service, focusing on improving employees' service attitudes is necessary.
Relating aspects of critical nutrition literacy at the personal level: using structural equation modelling to empirically test hypotheses
Authors: Naigaga Desire Alice , Pettersen Kjell Sverre , Henjum Sigrun , Guttersrud Øystein 
Published: December 2019

Abstract
Background: Whereas the majority of efforts targeting adolescents’ dietary behaviour have predominantly focused on improving their access to nutrition information, findings indicate that this approach has had little if any effect on their short-term dietary behaviour. Among the reasons for this is that adolescents report finding it difficult to understand the nutrition information that they access, and are thus unable to use the information as intended. Exploring critical nutrition literacy (CNL) might provide insight into how adolescents evaluate and apply the nutrition information that they get from different sources.Methods: The present study employed a cross-sectional study design, in which we sampled 1620 tenth graders, aged 15 and 16 years, enrolled at 58 secondary schools in Norway. Data collection: Using an electronic survey system, the participants responded to scales measuring ‘self-efficacy in Body and Health’ (SEBH), ‘evaluation of nutrition information’ (CNLEval and ‘engagement in dietary behaviour’ (CNLEng). Study hypotheses: We hypothesized that SEBH influences adolescents’ CNLEval and CNLEng, and that CNLEval influences CNLEng directly and mediates the effect of SEBH on CNLEng. Statistical analyses: Using Lisrel 9.30, the present study formulated and evaluated a hypothesized structural equation model (SEM) linking the two subdomains of CNL (CNLEval, CNLEng) and SEBH.Results: The study yielded a simple yet theoretically sound model linking CNL and SEBH; the adequate fit to the goodness-of-fit indices showed that the proposed model adequately described the data.Conclusions: The present study strengthened the hypothesis that there exists a strong association between CNL and SEBH, and between the two aspects of CNL-CNLEval and CNLEng. Hence, efforts aimed at promoting positive dietary behaviour in adolescents and enhancing their nutrition literacy efforts might benefit from enhancing their perceived self-efficacy in nutrition related subjects.
Facing obesity in pain rehabilitation clinics: profiles of physical activity in patients with chronic pain and obesity – a study from the Swedish Quality Registry for Pain Rehabilitation (SQRP)
Authors: Dong Huan-Ji , Larsson Britt , Fischer Marcelo Rivano , Gerdle Björn 
Published: December 2019

Abstract
Background: Due to the obesity epidemic, pain rehabilitation clinics have had to reconsider how to best serve their patients. To date, little is known about baseline level of physical activity (PA) in patients referred to pain rehabilitation clinics.Objectives: To investigate the PA levels of patients referred to pain rehabilitation clinics and to evaluate the effect of excess weight on PA level.Methods: Data were obtained from the Swedish Quality Registry for Pain Rehabilitation (SQRP) between 2016 and 2017. These data included PA time, Body Mass Index (BMI), sociodemographic factors, chronic pain and psychological aspects (e.g., pain intensity, depressive and anxiety symptoms and insomnia problems). The SQRP collects data on PA using a questionnaire that asks patients to indicate how much time they spend on everyday PA and physical exercise (PE) per week. Insufficient PA was defined as less than 150 minutes per week. We performed logistic regressions as well as orthogonal partial least square regression to estimate the effects of excess weight on PA.Results: Over one-fourth of the patients were classified as obese (BMI ≥30 kg/m 2 , 871/3110, 25.3%) and nearly one-third of these patients were classified as severely obese (BMI ≥35 kg/m 2 , 242/871, 27.8%). Time estimations for PE varied among the BMI groups, but patients in the higher BMI category were more likely to spend less time on everyday PA. After controlling for sociodemographic factors, pain, and psychological aspects, mild obesity (OR 0.65, 95% CI 0.53-0.81) and severe obesity (OR 0.56, 95% CI 0.42-0.74) were associated with less PA. Compared to normal weight peers, mild obese patients had an elevated risk of 65% and severe obese patients had an elevated risk of 96% for insufficient PA. For obese patients, increased pain intensity was positively related to insufficient PA (OR 1.17, 95% CI 1.06-1.29).Conclusion: Having low PA is very common for patients referred to pain rehabilitation clinics, especially for those with comorbid obesity. As a first step to increase PA, obese patients need to be encouraged to increase the intensity and amount of less painful daily PA.
Ankle arthrodesis-Open versus arthroscopic in the Treatment of Ankle Arthritis: A meta-analysis
Authors: Mok Tsz Ngai , He Qiyu , Panneerselvam Soundarya , Hou Huige , Wang Huajun , Zheng Xiaofei , Pan Jinghua , Li Jieruo 
Published: December 2019

Abstract
Background: This study intends in evaluating the comparsion between arthroscopic arthrodesis and open surgery for patients with ankle arthritis by performing a meta-analysis. Methods: A literature search for this meta-analysis was conducted using four English databases (Pubmed, Embase, Medline and the Cochrane Library), up to August 2019. These included two prospective cohort study and 7 retrospective cohort studies, enrolling a total of 507 patients with ankle arthritis. Result: For fusion rate, the pooled data showed significantly higher rate of fusion during the arthroscopic arthrodesis compared with open surgery (odds ratio 0.25, 95% CI 0.11 to 0.57, p = 0.0010). Regarding to the estimated blood loss, the pooled data showed significantly smaller blood losses during arthroscopic arthrodesis as compared with open surgery (WMD 52.04, 95% CI 14.14 to 89.94, p = 0.007). For tourniquet time, the pooled data showed smaller tourniquet time during arthroscopic arthrodesis compared with open surgery (WMD 22.68, 95% CI 1.92 to 43.43, p = 0.03). In the length of stay in the hospital, the pooled data showed less time of hospitalization for patients undergoing arthroscopic arthrodesis compared with open surgery (WMD 1.62, 95% CI 0.97 to 2.26, p < 0.00001). The pooled data showed better recovery for the patients who experienced arthroscopic arthrodesis as compared with open surgery at 1 year (WMD 14.73, 95% CI 6.66 to 22.80, p = 0.0003). Conclusion: For patients with ankle arthritis, arthroscopic arthrodesis seems to be associated with a higher fusion rate, lesser amount of estimated blood loss, shorter tourniquet time, shorter length of hospitalization and better functional improvement at 1 year.
Determinants of managers' self-rated health in Chinese petroleum-producing enterprises
Authors: Zhu Paiyi , Zhang Yong , Guo Jianwei , Zhou Peien , Huang Yixiang , Zhang Lingling 
Published: December 2019

Abstract
Background Self-rated health (SRH) is widely used by health institutions due to its validity, reliability, predicted power for mortality and morbidity and simplicity of collection. However, limited research has been conducted to measure the health and explore the determinants of SRH among managers, especially in petroleum enterprises in China. The purpose of this study was to measure the overall health and identify the determinants of SRH among managers in petroleum production enterprises in China. We committed to provide evidence to improve managers’ health status by exploring the determinants of SRH.Methods From March 2017 to December 2018, 417 managers participated and were categorized into different gender and age groups. The effective rate was 84.2%. The scores for physical, mental and social health subscales were converted to binary categorical variables, and univariate and multivariate logistic regression analyses were used to identify the determinants of SRH.Results The mean scores for SRH measurement scale (MS) dimensions ranged from 65.69 ± 18.13 (mean ± SD) for positive emotion (M2) to 91.81 ± 15.18 for daily physical activities (B2). The findings showed that lower-income and medium-managerial-level managers in the 41- to 50-year-old age group and lower-income male participants were more likely to be of poor mental health, while lower-income managers in the middle age groups and middle-aged female managers tended to report poor social health.Conclusions This study is the first in the Chinese energy industry to report on SRH and its determinants among managers stratified by age and gender. We found that income and managerial level are the main determinants among the managers, especially for those of middle age. Psychological counseling and a harmonious and mutually supportive working environment can contribute to addressing the special needs of managers in Chinese petroleum-producing enterprises.
Ten years risk assessment of Atherosclerotic cardiovascular disease using Astro-CHARM and Pooled Cohort Equation in a South Asian population
Authors: Ashraf Tariq , Mengal Muhammad Naeem , Muhammad Atif Sher , Tareen Asal Khan , Khan Muhammad Nauman , Kazmi Khawar , Nadeem Asif , Sarwar Shakil , Bashir Zara , Qamar Nadeem , Karim Musa 
Published: December 2019

Abstract
Background Atherosclerotic cardiovascular diseases (ASCVD) are on the rise in low and middle income countries attributed to modern sedentary lifestyle and dietary habits. This has led to need of assessment of the burden of at-risk population so that prevention measures can be developed. The objective of this study was to assess ten years risk assessment of ASCVD using Astro-CHARM and Pooled Cohort Equation (PCE) in a South Asian population.Methods A total of 386 residents of all six districts of Karachi with no ASCVD were enrolled in the study. The inclusion criteria consisted of age 40 years or above and either gender. Study participants were enrolled after obtaining informed written consent and those study participants who were found to have either congenital heart disease or valvular heart diseases or ischemic heart disease were excluded from the study based on initial screening. For the calculation of 10 years risk of ACVD based on Astro-CHARM and PCE, the variables were obtained including medical history and coronary artery calcium and C-reactive protein measurements.Results Mean estimated 10-year risk of fatal or non-fatal myocardial infarction or stroke as per the Astro-CHARM was 13.98±8.01%, while Mean estimated 10-year risk of fatal or non-fatal myocardial infarction or stroke as per the PCE was 22.26±14.01%. Based on Astro-CHARM, 11.14% of the study participants were labelled as having high risk, while PCE estimated 20.73% of study participants as having high risk of ASCVD.Conclusion Despite the fact that our findings showed substantial differences in ten-year risk of ASCVD between Astro-CHARM and PCE, both calculators can be used to develop a new population specific risk estimator for the South Asian population. Our study provides the first step towards developing a risk assessment guided decision making protocol for primary prevention of ASCVD for South Asian population.
Evaluations of knowledge, skills and practices of insulin storage and injection handling techniques of patients in Ethiopian primary hospitals
Authors: Netere Adeladlew Kassie , Ashete Eyayaw , Gebreyohannes Eyob Alemayehu , Belachew Sewunet Admasu 
Published: December 2019

Abstract
Background: Diabetes mellitus is a group of metabolic disorders and resulting from deficits in insulin secretion, insulin action, or both. Insulin therapy is primarily required to attain the recommended goal of blood sugar. The primary aim of this study was to evaluate the knowledge, skills and practices of insulin storage and injection technique of patients.Methods: An interview based cross-sectional study was conducted in conveniently selected participants in Northwest Ethiopian primary hospitals from March, 1, 2019 to May, 30, 2019. Knowledge and practice were measured by administering structured questionnaire with a Likert scale of 1–5 through face-to-face interviews and skills were assessed by five observational (demonstration) techniques from a total of 166 clients.Results: Of the total 166 participants, 54.8% were males and the mean age was 38.33±14 years. The overall knowledge (65.4%.) and practice (53.89%) rate on insulin storage and handling techniques were showed moderate knowledge and fair practices. About 94.6% of participants correctly shown insulin injection sites. One-way ANOVA showed that the level of education [F (3, 162) = 7.283, p<0.001], ways of instruction of insulin injection [F (2, 163) =3.32, p = 0.039], insulin therapy duration [F (3,162) = 3.59, p= 0.015] and assessing insulin storage [F (2,163) = 4.45, p = 0.013] had a significant effect on level of knowledge. Similarly, knowledge level [F (2,163) = 14.17, p < 0.001], educational status [F (3,162) = 10.57, p <0.001], occupation type [F (4,161) = 5.43, p <0.001], time since insulin therapy [F (3, 162) = 5.46, p = 0.001] and diagnosis [F (3,162) = 3.36, p= 0.02] had a significant effect on patients’ insulin storage and administration practices. Conclusion: Patient had marginal knowledge and practices on insulin storage and administration techniques. The patients’ skills on the important and critical steps of administrations are poor. The engagements of healthcare professionals and stakeholders should be in developments of instructions and guidelines are very crucial in addition to focusing on educating and changing their wrong perceptions, believes and attitudes towards storage and administering techniques.
Adiposity reduce prevalence of osteoporosis in Chinese rural population: the Henan Rural Cohort Study
Authors: Tian Huiling , Pan Jun , Qiao Dou , Dong Xiaokang , Li Ruiying , Wang Yikang , Tu Runqi , Abdulai Tanko , Liu Xiaotian , Hou Jian , Zhang Gongyuan , Wang Chongjian 
Published: December 2019

Abstract
Background: Adiposity plays a crucial role in the risk of osteoporosis. However, the impact of body fat distribution on the skeleton is contentious. The study was designed to explore the association of various adiposity indices on bone mineral density (BMD) and osteoporosis based on body mass index (BMI), body fat percentage (BFP),waist circumference (WC), waist to hip ratio (WHR), waist to height ratio (WHtR), and visceral fat index (VFI).Methods: A total of 8475 subjects derived from the Henan Rural Cohort Study were analyzed. The BMD of study participants were measured by calcaneal quantitative ultrasound (QUS). Linear and binary logistic regression was performed to estimate the association of adiposity and the outcomes.Results: The crude and age-standardized prevalence of osteoporosis was 20.15% and 14.39%. Per unit increment in adiposity indices was associated with 0.008-0.014g/cm2 increase in BMD. The adjusted odds ratios (95% confidence interval) of osteoporosis for per 1 SD increase in WC, WHR, WHtR, BMI, BFP, and VFI were 0.756 (0.713-0.801), 0.774 (0.728-0.822), 0.763 (0.720-0.809), 0.746 (0.703-0.792), 0.794 (0.729-0.865), and 0.735 (0.688-0.786), respectively. Stratified analyses indicated greater effects on individuals aged 55 years or more.Conclusions: The adiposity indices have an inverse association with the risk of osteoporosis among Chinese rural population, especially in the elderly. Keywords: Adiposity; Bone mineral density; Osteoporosis; Rural population
Burnout Syndrome, Extracurricular Activities and Social Support Among Brazilian Internship Medical Students: a Cross-Sectional Analysis.
Authors: Fontana Maria Carolina Pedro , Generoso Igor Prado , Sizilio Alexandre , Bivanco-Lima Danielle 
Published: December 2019

Abstract
Background: Burnout syndrome (BS) is highly prevalent among medical students and is associated with lower empathy and worsening of medical students ́ mental health. The aim of our study was to identify prevalence of BS during internship and its association with self-related social support and participation in extracurricular activities in one medical school in Brazil. Methods: This was a cross-sectional study conducted in 2015, with 121 medical students on internship (56% response rate). They were evaluated using the Maslach Burnout Inventory – Human Services (MBI) and assessed about socio demographic data, social support and extracurricular activities. Results: The overall BS prevalence was 57.5% among medical interns. High emotional exhaustion was present in 33.1% (N=38) of interns, high depersonalization was observed in 45.7% (N=58) and 36.2% of participants (N=46) had low personal accomplishment. Individuals with participation in community services had lower frequency of depersonalization (PR 0.61 CI95% 0.42-0.88). BS was not associated with different types of extracurricular activities and no association was found among BS and the behaviour of seeking social support. Conclusions: We found high prevalence of BS in medical interns, however the behaviour of seeking social support had no association with BS. The interns participating in community activities had lower frequency of high depersonalization.
Anticoccidial effect of "Shi Ying Zi" Powder in chickens infected with Eimeria tenella
Authors: Song Xu , Li Yunhe , Chen Yaqin , Jia Renyong , Huang Yongyuan , Yong Ting , Zou Yuanfeng , Li Lixia , Zhao Xinxin , Yin Zhongqiong 
Published: December 2019

Abstract
BackgroundCoccidiosis is one of the most economically important diseases affecting the poultry industry. Currently, anticoccidial drugs used in veterinary clinical showed many deficiencies, and new control measures are urgently needed. Many plant-derived drugs, such as herbal extracts, showed effects with less drug residues and resistance. Development of herbal medicine as the anticoccidial drug is one of the most prospective method for treating coccidiosis.Methods“Shi Ying Zi” powder is consisted of Cnidium monnieri (L.) Cuss, Taraxacum mongolicum Hand-Mazz and salt with the proportion of 55: 40: 5 (g/g/g). 200 1-day-old broiler chicks free of coccidiosis were equally divided into 10 groups: normal group, untreated group, 4 protective groups (positive control group and three “Shi Ying Zi” powder groups) and 4 therapeutical groups (positive control group and three “Shi Ying Zi” powder groups). At 11th day of age, the chicks in the four protective groups were prophylactically supplemented with “Shi Ying Zi” powder at the doses of 5g/kg, 10g/kg and 15g/kg and monensin (100mg/kg), respectively. At 14th day of age, chicks except those in blank group were inoculated with 2×104 sporulated oocysts of E. tenella. When the first hemorrhagic fecal was found, therapeutical drugs started administration. The low (5g/kg), medium (10g/kg) and high doses (15g/kg) of “Shi Ying Zi” powder were added into the diet, respectively. Sulfachloropyrazine sodium (positive control) was added into water (1g/L). The anti-coccidial index, biochemical parameters and tissue lesions were determined from 4 d post infection to 8 d post infection.ResultsSupplement with “Shi Yin Zi” powder for 3d prior to infection or after infection could improve the survival rate and relative growth rate and alleviate the pathological changes in the cecum, liver and kidney. “Shi Yin Zi” powder could recover the contents of glutamic-pyruvic transaminase, creatinine, albumin and triglycerides in serum. The hemorrhage and total number of oocysts in feces were reduced. The anti-coccidial index reaches to 165. The anti-coccidial effects were equal to positive controls (monensin and sulfamlopyrazine). Conclusions﻿“Shi Ying Zi” powder possesses potent anticoccidial effect and exhibits the potential to control E.tenella infection.