bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chebyshev wavelets operational matrices for solving nonlinear variable-order fractional integral equations
Authors: Yang Y. , Heydari M. H. , Avazzadeh Z. , Atangana A. 
Published: October 2020

Abstract
In this study, a wavelet method is developed to solve a system of nonlinear variable-order (V-O) fractional integral equations using the Chebyshev wavelets (CWs) and the Galerkin method. For this purpose, we derive a V-O fractional integration operational matrix (OM) for CWs and use it in our method. In the established scheme, we approximate the unknown functions by CWs with unknown coefficients and reduce the problem to an algebraic system. In this way, we simplify the computation of nonlinear terms by obtaining some new results for CWs. Finally, we demonstrate the applicability of the presented algorithm by solving a few numerical examples.
Existence and approximate controllability of Hilfer fractional evolution equations with almost sectorial operators
Authors: Bedi Pallavi , Kumar Anoop , Abdeljawad Thabet , Khan Zareen A. , Khan Aziz 
Published: October 2020

Abstract
In this article, we are concerned with the existence of mild solutions and approximate controllability of Hilfer fractional evolution equations with almost sectorial operators and nonlocal conditions. The existence results are obtained by first defining Green’s function and approximate controllability by specifying a suitable control function. These results are established with the help of Schauder’s fixed point theorem and theory of almost sectorial operators in a Banach space. An example is also presented for the demonstration of obtained results.
On a Kirchhoff diffusion equation with integral condition
Authors: Nam Danh Hua Quoc , Baleanu Dumitru , Luc Nguyen Hoang , Can Nguyen Huu 
Published: October 2020

Abstract
This paper is devoted to Kirchhoff-type parabolic problem with nonlocal integral condition. Our problem has many applications in modeling physical and biological phenomena. The first part of our paper concerns the local existence of the mild solution in Hilbert scales. Our results can be studied into two cases: homogeneous case and inhomogeneous case. In order to overcome difficulties, we applied Banach fixed point theorem and some new techniques on Sobolev spaces. The second part of the paper is to derive the ill-posedness of the mild solution in the sense of Hadamard.
Efficiencies of unconventional bulking agents in composting food waste in Korea
Authors: Lee Jae-Han , Luyima Deogratius , Lee Chang-Hoon , Park Seong-Jin , Oh Taek-Keun 
Published: October 2020

Abstract
Sawdust is the main bulking agent used to compost food waste in Korea but it is not an economically desirable choice because its availability entirely depends on imports. Since food waste composting provides agricultural, environmental and economic benefits, it is vital that we search for suitable replacements to sawdust from the locally available materials. In this study, we assessed the composting characteristics of food waste amended with various bulking agents including sawdust, ginkgo leaves, insect feces, and mushroom waste. Each of the bulking agents was mixed with the food waste in ratios of 3:7, respectively. Even though the initial temperatures were highest in the mixture of the food waste and insect feces whose temperature stood at 65 °C against 39, 58 and 51 °C in the sawdust, ginkgo leaves and mushroom waste mixtures, respectively on the third day of the experiment (DAT 3), it was terminated on the 21st day (DAT 21) because of excessively high water content (70.92%). The water content of the composted food waste supplemented with sawdust, mushroom waste, and ginkgo leaves stood at 51.28, 39.81, and 44.92%, respectively at the end of the experiment and therefore, the fully mature composts satisfied the water content requirement of less than 55% established by the Rural Development Agency of the ministry of Agriculture of Korea. The results of the CoMMe-101, Solvita and seed germination index indicated that the composted food waste amended with the mushroom waste and ginkgo leaves matured relatively quicker than that of the sawdust amendment. Based on the above observations, it is clear that the mushroom waste and ginkgo leaves are actually more effective bulking agents than the sawdust and as such, are recommended as suitable replacements for sawdust in food waste composting.
A machine learning analysis of serious misconduct among Australian police
Authors: Cubitt Timothy I. C. , Wooden Ken R. , Roberts Karl A. 
Published: October 2020

Abstract
Fairness in policing, driven by the effective and transparent investigation and remediation of police misconduct, is vital to maintaining the legitimacy of policing agencies, and the capacity for police to function within society. Research into police misconduct in Australia has traditionally been performed on an ad-hoc basis, with limited access to law enforcement data. This research seeks to identify the antecedents of serious police misconduct, resulting in the dismissal or criminal charge of officers, among a large police misconduct dataset. Demographic and misconduct data were sourced for a sample of 600 officers who have committed instances of serious misconduct, and a matched sample of 600 comparison officers across a 13-year period. A machine learning analysis, random forest, was utilised to produce a robust predictive model, with Partial Dependence Plots employed to demonstrate within variable interaction with serious misconduct. Prior instances of serious misconduct were particularly predictive of further serious misconduct, while misconduct was most prominent around mid-career. Secondary employment, and performance issues were important predictors, while demographic variables typically outperformed complaint variables. This research suggests that serious misconduct is similarly prevalent among experienced officers, as it is junior officers, while secondary employment is an important indicator of misconduct risk. Findings provide guidance for misconduct prevention policy among policing agencies.
Associations between stuttering, comorbid conditions and executive function in children: a population-based study
Authors: Choo Ai Leen , Smith Sara Ashley , Li Hongli 
Published: October 2020

AbstractBackgroundThe aim of this study was to investigate the relationship between executive function (EF), stuttering, and comorbidity by examining children who stutter (CWS) and children who do not stutter (CWNS) with and without comorbid conditions. Data from the National Health Interview Survey were used to examine behavioral manifestations of EF, such as inattention and self-regulation, in CWS and CWNS.MethodsThe sample included 2258 CWS (girls = 638, boys = 1620), and 117,725 CWNS (girls = 57,512; boys = 60,213). EF, and the presence of stuttering and comorbid conditions were based on parent report. Descriptive statistics were used to describe the distribution of stuttering and comorbidity across group and sex. Regression analyses were to determine the effects of stuttering and comorbidity on EF, and the relationship between EF and socioemotional competence.ResultsResults point to weaker EF in CWS compared to CWNS. Also, having comorbid conditions was also associated with weaker EF. CWS with comorbidity showed the weakest EF compared to CWNS with and without comorbidity, and CWS without comorbidity. Children with stronger EF showed higher socioemotional competence. A majority (60.32%) of CWS had at least one other comorbid condition in addition to stuttering. Boys who stutter were more likely to have comorbid conditions compared to girls who stutter.ConclusionPresent findings suggest that comorbidity is a common feature in CWS. Stuttering and comorbid conditions negatively impact EF.
RNA dependent suppression of C9orf72 ALS/FTD associated neurodegeneration by Matrin-3
Authors: Ramesh Nandini , Daley Elizabeth L. , Gleixner Amanda M. , Mann Jacob R. , Kour Sukhleen , Mawrie Darilang , Anderson Eric N. , Kofler Julia , Donnelly Christopher J. , Kiskinis Evangelos , Pandey Udai Bhan 
Published: October 2020

Abstract
The most common genetic cause of amyotrophic lateral sclerosis (ALS) is a GGGGCC (G4C2) hexanucleotide repeat expansions in first intron of the C9orf72 gene. The accumulation of repetitive RNA sequences can mediate toxicity potentially through the formation of intranuclear RNA foci that sequester key RNA-binding proteins (RBPs), and non-ATG mediated translation into toxic dipeptide protein repeats. However, the contribution of RBP sequestration to the mechanisms underlying RNA-mediated toxicity remain unknown. Here we show that the ALS-associated RNA-binding protein, Matrin-3 (MATR3), colocalizes with G4C2 RNA foci in patient tissues as well as iPSC-derived motor neurons harboring the C9orf72 mutation. Hyperexpansion of C9 repeats perturbed subcellular distribution and levels of endogenous MATR3 in C9-ALS patient-derived motor neurons. Interestingly, we observed that ectopic expression of human MATR3 strongly mitigates G4C2-mediated neurodegeneration in vivo. MATR3-mediated suppression of C9 toxicity was dependent on the RNA-binding domain of MATR3. Importantly, we found that expression of MATR3 reduced the levels of RAN-translation products in mammalian cells in an RNA-dependent manner. Finally, we have shown that knocking down endogenous MATR3 in C9-ALS patient-derived iPSC neurons decreased the presence of G4C2 RNA foci in the nucleus. Overall, these studies suggest that MATR3 genetically modifies the neuropathological and the pathobiology of C9orf72 ALS through modulating the RNA foci and RAN translation.
Dog leucocyte antigen (DLA) class II haplotypes and risk of canine diabetes mellitus in specific dog breeds
Authors: Denyer A. L. , Massey J. P. , Davison L. J. , Ollier W. E. R. , Catchpole B. , Kennedy L. J. 
Published: October 2020

AbstractBackgroundCanine diabetes mellitus (DM) is a common endocrine disease in domestic dogs. A number of pathological mechanisms are thought to contribute to the aetiopathogenesis of relative or absolute insulin deficiency, including immune-mediated destruction of pancreatic beta cells. DM risk varies considerably between different dog breeds, suggesting that genetic factors are involved and contribute susceptibility or protection. Associations of particular dog leucocyte antigen (DLA) class II haplotypes with DM have been identified, but investigations to date have only considered all breeds pooled together. The aim of this study was to analyse an expanded data set so as to identify breed-specific diabetes-associated DLA haplotypes.MethodsThe 12 most highly represented breeds in the UK Canine Diabetes Register were selected for study. DLA-typing data from 646 diabetic dogs and 912 breed-matched non-diabetic controls were analysed to enable breed-specific analysis of the DLA. Dogs were genotyped for allelic variation at DLA-DRB1, -DQA1, -DQB1 loci using DNA sequence-based typing. Genotypes from all three loci were combined to reveal three-locus DLA class II haplotypes, which were evaluated for statistical associations with DM. This was performed for each breed individually and for all breeds pooled together.ResultsFive dog breeds were identified as having one or more DLA haplotype associated with DM susceptibility or protection. Four DM-associated haplotypes were identified in the Cocker Spaniel breed, of which one haplotype was shared with Border Terriers. In the three breeds known to be at highest risk of DM included in the study (Samoyed, Tibetan Terrier and Cairn Terrier), no DLA haplotypes were found to be associated with DM.ConclusionsNovel DLA associations with DM in specific dog breeds provide further evidence that immune response genes contribute susceptibility to this disease in some cases. It is also apparent that DLA may not be contributing obvious or strong risk for DM in some breeds, including the seven breeds analysed for which no associations were identified.
Enzymatic activities and analysis of a mycelium-based composite formation using peach palm (Bactris gasipaes) residues on Lentinula edodes
Authors: de Lima Gabriel Goetten , Schoenherr Zaira Chiodini Pedri , Magalhães Washington Luiz Esteves , Tavares Lorena Benathar Ballod , Helm Cristiane Vieira 
Published: October 2020

Abstract
By seeding fungus on top of industry residues, a mycelium can grow and form a compact network structure; however, it may not develop due to lack of optimal nutrients from the substrate. Consequently, peach-palm residues can be a potential alternative; so, to test this hypothesis, this work evaluates the effect of peach-palm residues as substrate for the growth of mycelium based on Lentinula edodes. They were also supplemented with cassava bran and various sources of nitrogen-ammonium sulphate, potassium nitrate, and soy flour—to analyse its effects on its physico-chemical, enzymatic activities, and thermal and mechanical properties of the final composite at 12 and 20 days of cultivation. This mycelium was able to grow at optimum source treatment conditions, which depends on the ratio of Carbon to Nitrogen, within only 12 days of inoculation. Furthermore, the enzyme activities directly correlate with the mycelium growth with optimum conditions of pH, water activity, and moisture for L. edodes to grow having lower enzyme activities for a well-developed composite; whereas higher activities were seen for a weakly developed material, and this material demonstrates mechanical and thermal properties similar to common mycelium-based composites. Therefore, this work demonstrates that peach-palm residues can be a potential alternative for mycelium-based composite.
Guidance for conducting feasibility and pilot studies for implementation trials
Authors: Pearson Nicole , Naylor Patti-Jean , Ashe Maureen C. , Fernandez Maria , Yoong Sze Lin , Wolfenden Luke 
Published: October 2020

Abstract

Background
Implementation trials aim to test the effects of implementation strategies on the adoption, integration or uptake of an evidence-based intervention within organisations or settings. Feasibility and pilot studies can assist with building and testing effective implementation strategies by helping to address uncertainties around design and methods, assessing potential implementation strategy effects and identifying potential causal mechanisms. This paper aims to provide broad guidance for the conduct of feasibility and pilot studies for implementation trials.

Methods
We convened a group with a mutual interest in the use of feasibility and pilot trials in implementation science including implementation and behavioural science experts and public health researchers. We conducted a literature review to identify existing recommendations for feasibility and pilot studies, as well as publications describing formative processes for implementation trials. In the absence of previous explicit guidance for the conduct of feasibility or pilot implementation trials specifically, we used the effectiveness-implementation hybrid trial design typology proposed by Curran and colleagues as a framework for conceptualising the application of feasibility and pilot testing of implementation interventions. We discuss and offer guidance regarding the aims, methods, design, measures, progression criteria and reporting for implementation feasibility and pilot studies.

Conclusions
This paper provides a resource for those undertaking preliminary work to enrich and inform larger scale implementation trials.
Introducing virtual reality therapy for inpatients with dementia admitted to an acute care hospital: learnings from a pilot to pave the way to a randomized controlled trial
Authors: Appel Lora , Kisonas Erika , Appel Eva , Klein Jennifer , Bartlett Deanna , Rosenberg Jarred , Smith Christopher 
Published: October 2020

Abstract

Background
Behavioural and psychological symptoms of dementia (BPSD) are difficult to manage, particularly in acute care settings. As virtual reality (VR) technology becomes increasingly accessible and affordable, there is growing interest among clinicians to evaluate VR therapy in hospitalized patients, as an alternative to administering antipsychotics/sedatives or using physical restraints associated with negative side effects.

Objectives
Validate and refine the proposed research protocol for a randomized controlled trial (RCT) that evaluates the impact of VR therapy on managing BPSD in acute care hospitals. Special attention was given to ascertain the processes of introducing non-pharmacological interventions in acute care hospitals.

Methods
Ten patients 65 years or older (mean = 87) previously diagnosed with dementia, admitted to an acute care hospital, were recruited over 3-month period into a prospective longitudinal pilot study. The intervention consisted of viewing 20-min of immersive 360° VR using a head-mounted display. Baseline and outcomes data were collected from the hospital electronic medical records, pre/post mood-state questionnaires, Neuropsychiatric Inventory (NPI) score, and standardized qualitative observations. Comprehensive process data and workflow were documented, including timestamps for each study task and detailed notes on personnel requirements and challenges encountered.

Results
Of 516 patients admitted during the study, 67 met the inclusion/exclusion criteria. In total, 234 calls were initiated to substitute decision makers (SDM) of the 67 patients for the consenting process. Nearly half (45.6%) of SDMs declined participation, and 40% could not be reached in time before patients being discharged, resulting in 57 eligible patients not being enrolled. Ten consented participants were enrolled and completed the study. The initial VR session averaged 53.6 min, largely due to the administration of NPI (mean = 19.5 min). Only four participants were able to respond reliably to questions. Seven participants opted for additional VR therapy sessions; of those providing feedback regarding the VR content, they wanted more varied scenery (animals, fields of flowers, holiday themes). Few sessions (4/18) encountered technical difficulties.

Conclusion
The pilot was instrumental in identifying issues and providing recommendations for the RCT. Screening, inclusion criteria, consenting, data collection, and interaction with SDMs and hospital staff were all processes requiring changes and optimizations. Overall, patients with dementia appear to tolerate immersive VR, and with suggested protocol alterations, it is feasible to evaluate this non-pharmacological intervention in acute care hospitals.
Development and validation of a follow-up methodology for a randomised controlled trial, utilising routine clinical data as an alternative to traditional designs: a pilot study to assess the feasibility of use for the BladderPath trial
Authors:   the BladderPath trial management group, Mintz Harriet P. , Dosanjh Amandeep , Parsons Helen M. , Hughes Ana , Jakeman Alicia , Pope Ann M. , Bryan Richard T. , James Nicholas D. , Patel Prashant 
Published: October 2020

Abstract

Background
Bladder cancer outcomes have not changed significantly in 30 years; the BladderPath trial (Image Directed Redesign of Bladder Cancer Treatment Pathway, ISRCTN35296862) proposes to evaluate a modified pathway for diagnosis and treatment ensuring appropriate pathways are undertaken earlier to improve outcomes. We are piloting a novel data collection technique based on routine National Health Service (NHS) data, with no traditional patient-Health Care Professional contact after recruitment, where trial data are traditionally collected on case report forms. Data will be collected from routine administrative sources and validated via data queries to sites. We report here the feasibility and pre-trial methodological development and validation of the schema proposed for BladderPath.

Methods
Locally treated patient cohorts were utilised for routine data validation (hospital interactions data (HID) and administrative radiotherapy department data (RTD)). Single site events of interest were algorithmically extracted from the 2008–2018 HID and validated against reference datasets to determine detection sensitivity. Survival analysis was performed using RTD and HID data. Hazard ratios and survival statistics were calculated estimating treatment effects and further validating and assessing the scope of routine data.

Results
Overall, 829/1042 (sensitivity 0.80) events of interest were identified in the HID, with varying levels of sensitivity; identifying, 202/206 (sensitivity 0.98; PPV 0.96) surgical events but only 391/568 (sensitivity 0.69; PPV 0.95) radiotherapy regimens. An overall temporal quality improvement trend was present: detecting 41/117 events (35%) in 2011 to 104/109 (95%) in 2017 (all event types). Using the RTD, 5-year survival rates were 43% (95% CI 25–59%) in the chemoradiotherapy group and 30% (95% CI 23–36%) in the radiotherapy group; using the HID, the 5-year radical cystectomy survival rate was 57% (95% CI 50–63%).

Conclusions
Routine data are a feasible method for trial data collection. As long as events of interest are pre-validated, very high sensitivities for trial conduct can be achieved and further improved with targeted data queries. Outcomes can also be produced comparable to clinical trial and national dataset results. Given the real-time, obligatory nature of the HID, which forms the Hospital Episode Statistics (HES) data, alongside other datasets, we believe routine data extraction and validation is a robust way of rapidly collecting datasets for trials.
Why does uptake of family planning services remain sub-optimal among Nigerian women? A systematic review of challenges and implications for policy
Authors: Akamike Ifeyinwa Chizoba , Okedo-Alex Ijeoma Nkem , Eze Irene Ifeyinwa , Ezeanosike Obumneme Benaiah , Uneke Chigozie Jesse 
Published: October 2020

Abstract

Background
Over the years, family planning uptake in Nigeria has remained low and this is as a result of the various challenges and barriers faced by women. The aim of this study was to systematically review studies on family planning services undertaken in Nigeria in order to understand the challenges to uptake of the services and the policy implications.

Methods
A PubMed search was performed in June 2020 and studies that investigated challenges of family planning uptake in Nigeria published in English between 2006 and 2020 were sought. A combination of the search terms family planning, contraceptives, challenges, barriers, Nigeria was used. Review articles, case reports, and case studies were excluded. Studies that did not report barriers or challenges to family planning or contraceptives were excluded.

Result
Twenty seven studies carried out in Nigeria which provided sufficient information were identified and used for this review. The Uptake of family planning recorded in the reviewed studies ranges from 10.3 to 66.8%. Challenges that are client related include education, desire for more children, uncertainty about its need, partner disapproval, previous side effects, religious beliefs, culture disapproval, age, marital status, and wealth index, residence, ignorance, embarrassment, domestic violence and sexual factor. Health service related factors identified include cost, difficulty accessing services, and procurement difficulties. Recommendations for family planning propram and policy include targeting of health service delivery for improvement, focus on gender issues and male involvement, involvement of religious leaders, targeting of younger women for better education and counseling, and continuous awareness creation and counseling among others.

Conclusion
The review has shown that uptake of family planning remains low in Nigeria and challenges abound. We recommend that strategies that are multi-sectoral should be applied to address the multi-pronged challenges facing uptake of family planning services.