bluuebunny/crossref_metadata_2025_split huggingface dataset:
Migratory state is not associated with differences in neural glucocorticoid or mineralocorticoid receptor expression in pine siskins
Authors: Watts Heather E. , Rittenhouse Jeffrey L. , Sewall Kendra B. , Bowers J. Michael 
Published: December 2019

Abstract
Although the endocrine system likely plays an important role in orchestrating the transition to a migratory state, the specific mechanisms by which this occurs remain poorly understood. Changes in glucocorticoid signaling are one proposed mechanism that may be important in migratory transitions. Although previous work has focused on the role of changes in circulating glucocorticoids, another potential mechanism is changes in the expression of its cognate receptors. Here, we test this hypothesis by comparing mRNA expression of the genes for the mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) in two brain regions implicated in the regulation of migratory behavior (the hippocampus and hypothalamus) in pine siskins (Spinus pinus) sampled before or after the transition to a spring nomadic migratory state. Compared to pre-migratory birds, migratory birds had body conditions more indicative of physiological preparations for migration (e.g., larger body mass), and greater levels of nocturnal migratory restlessness. However, we found no differences between pre-migratory and migratory birds in the expression of GR or MR mRNA in either the hippocampus or hypothalamus. Thus, differences in expression of receptors for glucocorticoids do not appear to underly the observed differences in physiology and behavior across a migratory transition. Taken together with previous results showing no change in circulating corticosterone levels during this transition, our findings provide no evidence for a role of glucocorticoid signaling in the spring migratory transition of this species.
Shareholder Wealth Maximization and Investment Decisions of Nigerian Food and Beverage Companies
Authors: Shodiya Olayinka Abideen , Sanyaolu Wasiu Abiodun , Ojenike Joseph Olushola , Ogunmefun Gbadebo Tirimisiyu 
Published: December 2019

Abstract
The study examines the effect of shareholder wealth maximization on investment decision in food and beverage companies listed in Nigeria. To achieve this, seven listed food and beverage companies were selected. The research adopted an ex post facto research design, while purposeful and stratified sampling techniques were used to select seven out of the fifteen companies in the food and beverage subsector. Data for the study were extracted from the annual reports and accounts of the sampled companies from 2008–2017. The result obtained from the regression analysis reveals that earnings per share and market price per share have no significant positive effect on investment decisions, while dividend per share was found to have no significant negative effect on investment decisions. In effect, the study concludes that the unique combination of the identified proxies for shareholder wealth maximization have jointly a significant positive effect on investment decisions. Arising from this, the study recommends that food and beverage companies should improve more on earnings per share, dividend per share, and market price per share so as to attract more investment from shareholders.
A comprehensive evaluation for the prediction of mortality in intensive care units with LSTM networks: patients with cardiovascular disease
Authors: Maheshwari Saumil , Agarwal Aman , Shukla Anupam , Tiwari Ritu 
Published: December 2019

Abstract
Intensive care units (ICUs) are responsible for generating a wealth of useful data in the form of electronic health records. We aimed to build a mortality prediction model on a Medical Information Mart for Intensive Care (MIMIC-III) database and to assess whether the use of deep learning techniques like long short-term memory (LSTM) can effectively utilize the temporal relations among clinical variables. The models were built on clinical variable dynamics of the first 48 h of ICU admission of 12,550 records from the MIMIC-III database. A total of 36 variables including 33 time series variables and three static variables were used for the prediction. We present the application of LSTM and LSTM attention (LSTM-AT) model for mortality prediction with such a large number of clinical variables dataset. For training and validation purpose, we have used International Classification of Diseases, 9th edition (ICD-9) codes for extracting the patients with cardiovascular disease, and infections and parasitic disease, respectively. The effectiveness of the LSTM model is achieved over non-recurrent baseline models like naïve Bayes, logistic regression (LR), support vector machine and multilayer perceptron (MLP) by generating state of the art results (area under the curve [AUC], 0.852). Next, by providing attention at each time stamp, we developed a model, LSTM-AT, which exhibits even better performance (AUC, 0.876).
Gastrointestinal symptoms in pediatric patients with type 1 diabetes mellitus
Authors: Selbuz Suna , Buluş Ayşe Derya 
Published: December 2019

Abstract

Background
Various gastrointestinal (GI) symptoms are associated with diabetes. Common GI complaints associated with the manifestation of the disease include abdominal pain, diarrhea, nausea, bloating and vomiting. There have been very few studies examining GI problems of pediatric patients with type 1 diabetes mellitus (T1DM). The aims of this study were to find out the prevalence of GI symptoms in pediatric patients with T1DM and to determine the correlation among such symptoms, duration of diabetes and glycemic control.

Methods
One hundred and thirty-seven (median age 13.2 years, female 45.3%) patients with T1DM were examined. Demographic features, GI symptoms, signs and physical examination findings of the patients were recorded by pediatric gastroenterology specialists for the differential diagnosis and exclusion of other etiologies. Complete blood count, blood glucose, lipid profile, electrolytes, amylase, lipase, celiac antibodies and glycated hemoglobin (HbA1c) levels were evaluated and stool examination was performed. Endoscopy was performed on the patients who had refractory GI complaints. Gastric emptying (GE) time was evaluated using GE scintigraphy.

Results
Overall, 74 (54%) patients had ≥1 GI complaints. Patients often reported gastroesophageal reflux (32.8%) and abdominal pain (18%). The most significant findings in terms of GI symptoms were determined when patients were classified according to the glycemic control status. Reflux and dyspeptic symptoms were significantly more common in poorly or very poorly controlled diabetic patients (p=0.003 and p=0.004, respectively).

Conclusions
Diabetes can affect the entire GI tract, and GI symptoms are common in pediatric patients. We recommend that T1DM patients be evaluated for GI symptoms.
Messanlage zur Untersuchung des Seebeck-Effektes in Polymermaterialien
Authors: Jenschke Wolfgang , Ullrich Mathias , Krause Beate , Pötschke Petra 
Published: December 2019

Zusammenfassung
Der nach dem Physiker Thomas Johann Seebeck benannte thermoelektrische Effekt ist für alle wesentlichen Metalle hinreichend gut erforscht und wird seit langem unter anderem zur Temperaturmessung mittels Thermoelementen genutzt. Weniger bekannt und erforscht ist dieser Effekt in polymeren Werkstoffen, die aber heute auch in der Sensorindustrie immer mehr an Einfluss gewinnen. Im vorliegenden Artikel wird eine Messanlage beschrieben, die speziell für die Untersuchung des Seebeck-Effektes in polymeren Messobjekten mit dem Ziel aufgebaut wurde, maßgeschneiderte Polymere für sensorische technische Anwendungen zu entwickeln, die den Seebeck-Effekt nutzen. Die besonderen Anforderungen an die Messanlage liegen dabei in der Realisierung konstanter genauer Temperaturquellen.
Wnt Signaling Drives Ectopic Gene Expression and Larval Arrest in the Absence of theCaenorhabditis elegansDREAM Repressor Complex
Authors: Cherian Jerrin R , Adams Katherine V , Petrella Lisa N 
Published: December 2019

AbstractEstablishment and maintenance of proper gene expression is a requirement for normal growth and development. The DREAM complex in Caenorhabditis elegans functions as a transcriptional repressor of germline genes in somatic cells. At 26°, DREAM complex mutants show increased misexpression of germline genes in somatic cells and High Temperature Arrest (HTA) of worms at the first larval stage. To identify transcription factors required for the ectopic expression of germline genes in DREAM complex mutants, we conducted an RNA interference screen against 123 transcription factors capable of binding DREAM target promoter loci for suppression of the HTA phenotype in lin-54 mutants. We found that knock-down of 15 embryonically expressed transcription factors suppress the HTA phenotype in lin-54 mutants. Five of the transcription factors found in the initial screen have associations with Wnt signaling pathways. In a subsequent RNAi suppression screen of Wnt signaling factors we found that knock-down of the non-canonical Wnt/PCP pathway factors vang-1, prkl-1 and fmi-1 in a lin-54 mutant background resulted in strong suppression of the HTA phenotype. Animals mutant for both lin-54 and vang-1 showed almost complete suppression of the HTA phenotype, pgl-1 misexpression, and fertility defects associated with lin-54 single mutants at 26°. We propose a model whereby a set of embryonically expressed transcription factors, and the Wnt/PCP pathway, act opportunistically to activate DREAM complex target genes in somatic cells of DREAM complex mutants at 26°.
Leveraging Family History in Case-Control Analyses of Rare Variation
Authors: Solis-Lemus Claudia R , Fischer S Taylor , Todor Andrei , Liu Cuining , Leslie Elizabeth J , Cutler David J , Ghosh Debashis , Epstein Michael P 
Published: December 2019

AbstractStandard methods for case-control association studies of rare and common variation often treat disease outcome as a dichotomous phenotype. However, recent studies have demonstrated that cases with a family history of disease can be enriched...Standard methods for case-control association studies of rare variation often treat disease outcome as a dichotomous phenotype. However, both theoretical and experimental studies have demonstrated that subjects with a family history of disease can be enriched for risk variation relative to subjects without such history. Assuming family history information is available, this observation motivates the idea of replacing the standard dichotomous outcome variable used in case-control studies with a more informative ordinal outcome variable that distinguishes controls (0), sporadic cases (1), and cases with a family history (2), with the expectation that we should observe increasing number of risk variants with increasing category of the ordinal variable. To leverage this expectation, we propose a novel rare-variant association test that incorporates family history information based on our previous GAMuT framework for rare-variant association testing of multivariate phenotypes. We use simulated data to show that, when family history information is available, our new method outperforms standard rare-variant association methods, like burden and SKAT tests, that ignore family history. We further illustrate our method using a rare-variant study of cleft lip and palate.
The Chip and The Pale Truth by V. Zazubrin and Chocolate by A. Tarasov-Rodionov as “irrelevant” works: to the problem of “Red Terror” in the literature 1920s
Authors: Proskurina Elena 
Published: December 2019

In the article, the problem of «red terror» is revealed in a little-known material. The story of the Siberian writer V. Zazubrin (1895–1937) The Pale Truth (1923) was published only once in Soviet times – in 1923 in the journal “Siberian Lights”; the novella “Sliver” (1923) was not published during the life of the author and was first published only in 1989. The story of A. Tarasov-Rodionov (1885–1938) Chocolate (1922) was reprinted several times in the 1920s, after which it was forgotten for decades. The work traces the history of the creation of the Chip, which until now contains many “white spots”. The originality of the plot is revealed, in which the image of the main character contradicts the canon of the “iron knight of the revolution”: tired of his firing “hard work”, he is going crazy. The typological similarity of the Chip with the story Chocolate is shown, the plot of which is also based on the dramatic story of the hero. Particular attention is paid to the receptive dialogue of the story The Pale Truth notch with Chocolate: in both works, heroes devoted to the cause of the revolution become its innocent victims.Both works echo and, in their pathos of justifying the “Red Terror”, the idea of “the future of beautiful humanity”. In terms of creative reception, the plot rolls of The Pale Truth with Chocolate, similarities in the images of the main characters and individual elements of poetics are shown. The “irrelevance” of Zazubrin and Tarasov-Rodionov’s works for Soviet literature is substantiated. The main factor is the discrepancy between their plots and the leading ideological maxims of the era.
Ahmet Hamdi Tanpınar’ın Romanlarında Babalar ve “Ödipal Krizlerin Eşiğindeki” Oğullar Üzerine Bir Yorum Denemesi
Authors: KOÇ Murat 
Published: December 2019

Ahmet Hamdi Tanpınar’ın romanlarını zengin kılan bir nokta da, eserlerini tarih, güzel sanatlar,
psikoloji başta olmak üzere farklı disiplinlerle beslemesidir. Tanpınar’ın romanları sağlam bir psikolojik
yapıya sahiptir. Kahramanların birbirleriyle olan ilişkileri yanında insan-zaman-mekân münasebetini
de derin bir psikolojik yapıyla verir. Tanpınar Mahur Beste, Huzur, Sahnenin Dışındakiler romanlarında
baba-oğul ilişkisini Sigmund Freud’un “Oeidipus kompleksi” çerçevesinde işler. Behçet Bey ve Yaşar’ın
şahsında baskın karaktere sahip babaları tarafından beğenilmeyen, buna bağlı olarak Ödipal krizleri
atlatamayan erkek çocukların yaşayabileceği durumları ortaya koyar. İsmail Molla ve Tevfik Bey son derece
güçlü karaktere sahip babalardır. Bunun yanında musiki yoluyla eski İstanbul kültürünü hakkıyla taşırlar.
Onların oğullarından beklediği kendi hayat tarzı ve anlayışlarını devam ettirmeleridir. Saatleri Ayarlama
Enstitüsü’nde ise Tanpınar, Freud’un teorilerini tersine çevirir. Bu romanda oğlu tarafından beğenilmeyen ve
bu dairede krizler yaşayan babayla karşılaşırız. Oğlu Ahmet, başta hakiki iş ve çalışma olmak üzere, hayatın
temel değerlerine sahip olmayan Hayri İrdal’ı yargılar ve mahkûm eder. O aynı zamanda bütün yaşananların
yalan bir dünyadan ibaret olduğunu okuyucuya anlatmak için kurguya dahil edilmiştir. Kısacası Tanpınar’ın
dört romanı baba-oğul ilişkisi ve bunların ele alınışı yönünden incelemeye imkân vermektedir. Bu makalede
romanlar baba-oğul ilişkisi açısından incelenecek ve bir yorum denemesi yapılacaktır.
Göçebeleşme Döneminde (1018-1192) Türkiye’de Kurumlara İlişkin İnşa Faaliyeti Üzerine Bir Değerlendirme
Authors: POLAT M. Said 
Published: December 2019

Anadolu 1018-1192 yılları arasında büyük çoğunluğu göçebe hayat yaşayan Türkmenlerin göçüne
maruz kaldı. Begler ve sultanlar kurumsal olmayan siyasi yapılar oluştururken, Anadolu’ya göç eden
yerleşik Müslüman Türkler ve diğer Müslümanlar siyasi olmayan kurumsal yapılar oluşturdular ve inşa
faaliyetlerinde bulundular. Bu kurumsallaşma ve inşa faaliyetlerinin başlaması ve yaygınlaşması bölgelere
göre değişmektedir. Danişmendli Begliği’nin hakimiyeti altındaki şehirlerde XI. yüzyılın sonlarında
başlamakta, XII. yüzyılın ortalarına kadar birkaç yapı ile öne çıkmakta, XII. yüzyılın ortalarından itibaren
görece artmaktadır. Diğer beglikler ve Türkiye Selçukluları’nda ise XII. yüzyılın ortalarına kadar bir
yapılaşma görülmezken XII. yüzyılın ikinci yarısından itibaren yapılaşma görülmeye başlamaktadır. Bunda
Türkiye Selçukluları ve begliklerin dışarıya karşı ve kendi aralarında verdikleri mücadelenin belirleyici
olduğu tahmin edilmektedir. Bu mücadeleler askerileşmeyi artırmış ve gelirlerin büyük kısmının asker olarak
istihdam edilen Türkmenlere aktarılmasına sebep olmuş olmalıdır. Göçebelerin özellikle Türkiye’nin batı
bölgesine Türkiye Selçukluları hakimiyetindeki bölgeye yığılması Türkiye Selçukluları’nın siyasi ve askeri
olarak gücünü artırırken göçebelerin baskısına daha fazla maruz kalmasına, bu da bölgede yapılaşmanın
gecikmesine ve seyrekleşmesine neden olmuştur. Artuklu Begliği hakimiyeti altındaki şehirlerde XII.
yüzyılın ikinci yarısındaki yapılaşmanın, Türkiye’nin diğer şehirlerine nazaran daha zengin olduğu dikkati
çekmektedir. Bunda bu şehirlerdeki yerleşik Müslümanların yoğunluğunun da etkili olduğu tahmin
edilmektedir. Yapılaşmanın zamana göre dağılımı siyasi olmayan kurumsal yapıların siyasi yapılardan
bağımsız olarak ortaya çıktıklarını göstermektedir. Fakat niteliğinde siyasi yapının gücü ve yerleşiklikle
ilişkisinin belirleyici olduğu söylenebilir. Çalışma, 1192 öncesine ait cami, medrese ve sarayların inşa
zamanlarının tespiti esasına dayanmaktadır.
NAKİT YÖNETİMİNİ ETKİLEYEN DEĞİŞKENLER ÜZERİNE BIST PERAKENDE SEKTÖRÜNDE PANEL VERİ ANALİZİ
Authors: YILDIZ Berk , DEMİRELİ Erhan 
Published: December 2019

Bu çalışmanın amacı, Borsa
İstanbul (BİST) AŞ’de işlem gören ve perakende sektöründe faaliyet gösteren
işletmelerin nakit bulundurma politikalarına etkileyen faktörlerin tespit
edilmesidir. Çalışma kapsamında Kamuyu Aydınlatma Platformu (www.kap.gov.tr)
web sitesinden elde edilen ve 2009-2018 dönemini kapsayan 9 adet perakende
ticaret işletmesinin verileri panel veri yöntemi ile analiz edilmiştir. Çalışma
sürecinde nakit oranı bağımlı değişken olarak seçilmiş, buna karşılık kaldıraç
oranı, varlık yapısı, karlılık, likidite, büyüklük, varlıkların uzun vadeli
borçlarla finansmanı, büyüme fırsatları ve nakit temettü dağıtımı bağımsız
değişkenler olarak incelenmiştir. Elde
edilen sonuçlara göre incelenen dönemde Borsa İstanbul (BİST) AŞ’de işlem gören
ve perakende sektöründe faaliyet gösteren işletmelerin nakit bulundurma
politikaları üzerinde karlılık, büyüklük, likidite, uzun vadeli borçlanma
değişkenlerinin anlamlı bir etkisi olduğu görülmektedir.
YEREL BASINDA EKONOMİ HABERLERİ ÜZERİNE BİR İNCELEME: YEŞİL AMASYA ÖRNEĞİ (1930-1940)
Authors: KAHRAMAN Nazan 
Published: December 2019

Bu çalışma
medyanın siyasal iktidarla ilişkisini yazılı basındaki ekonomi haberleri
üzerinden irdelemeyi amaçlamaktadır. Çalışmanın konusu, Cumhuriyetin kuruluşunu
takip eden ve ekonomide yoğun devletçilik politikalarının uygulandığı
1930’larda basında ekonomi haberlerinin yer alma biçimidir. Bunun için iktidara yakın bir yerel gazete
olan Yeşil Amasya seçilmiştir. Araştırmada eleştirel söylem çözümlemesi yöntemi ile ekonomi haberleri incelenmiştir. Çalışma,
Yeşil Amasya’nın 1934-1940 arasındaki sayılarını kapsamaktadır. Bu kapsamda söz
konusu zaman aralığında yayınlanan ve ekonomi ile ilgili olan 43 haber
incelenmiştir. Çalışmanın en önemli sonucu, Yeşil Amasya’nın iktidarın
ekonomi politikalarını desteklediği ve bu politikaların halka benimsetilmesi
konusunda önemli bir rol üstlendiğidir. Bir diğer önemli sonuç, haberlerde
genellikle ardalan ve bağlam bilgisine yer verilmemiş olması ve böylece
sınırları haberde sunulan bilgilerle ve referanslarla çizilen bir çerçeve
okuyucuya sunulmuştur.Bu çalışma
medyanın siyasal iktidarla ilişkisini yazılı basındaki ekonomi haberleri
üzerinden irdelemeyi amaçlamaktadır. Çalışmanın konusu, Cumhuriyetin kuruluşunu
takip eden ve ekonomide yoğun devletçilik politikalarının uygulandığı
1930’larda basında ekonomi haberlerinin yer alma biçimidir. Bunun için iktidara yakın bir yerel gazete
olan Yeşil Amasya seçilmiştir. Araştırmada eleştirel söylem çözümlemesi yöntemi ile ekonomi haberleri incelenmiştir. Çalışma,
Yeşil Amasya’nın 1934-1940 arasındaki sayılarını kapsamaktadır. Bu kapsamda söz
konusu zaman aralığında yayınlanan ve ekonomi ile ilgili olan 43 haber
incelenmiştir. Çalışmanın en önemli sonucu, Yeşil Amasya’nın iktidarın
ekonomi politikalarını desteklediği ve bu politikaların halka benimsetilmesi
konusunda önemli bir rol üstlendiğidir. Bir diğer önemli sonuç, haberlerde
genellikle ardalan ve bağlam bilgisine yer verilmemiş olması ve böylece
sınırları haberde sunulan bilgilerle ve referanslarla çizilen bir çerçeve
okuyucuya sunulmuştur.
Monitoring the antimicrobial activity of antiseptic eye drops
Authors: Okolov Igor N. 
Published: December 2019

Introduction. Antiseptic drugs currently occupy an important place in the treatment and prevention of ocular infectious and inflammatory diseases. Often microorganisms are characterized not only by resistance to a single antibiotic, but also by the presence of multiple resistances, which limits the choice of an effective drug. This problem requires a detailed study and monitoring of the sensitivity of the main pathogens of ocular infections, not only to antibiotics but also to antiseptics.
The aim was to study the species composition of conjunctival microflora in patients with ocular surface infection and to evaluate the antimicrobial activity of antiseptic eye drops.
Materials and methods. Investigation was carried out in 20122018 in 4237 bacterial conjunctivitis patients. The sensitivity to antiseptic preparations of pathogens isolated from patients with conjunctivitis was detected.
Results. 1068 strains of microorganisms isolated from the conjunctival cavity of patients were tested. Gram-positive cocci dominated among clinically significant pathogens 47.4%. Antimicrobial activity of Vitabact eye drops against gram-positive cocci was higher than that of antiseptic Okomistin.
Summary. Antimicrobial activity of the studied antiseptics against gram-positive and gram-negative pathogens was different. It is necessary to conduct further research on the antimicrobial activity of antiseptic eye drops.
Is it possible to cut down the number of unknown etiology in uveitis?
Authors: Kuznetcova Tatiana I. , Astakhov Yury S. 
Published: December 2019

Background. According to the data in national literature, uveitis comprises 515% among all eye diseases. The etiological data on uveitis are still under discussion. Our
aim was to decrease the percent of undefined uveitis.
Methods. The first part was to collect the retrospective data on uveitis etiology (20082012). The second one consisted of examining all new patients seen in our uveitis center at the Department of Ophthalmology of the Academician I.P. Pavlov First State Medical University (20142016) with up to date methods, like laser photometry, dual angiography and other laboratory and instrumental investigational tests.
Results. The percent of unknown etiology was decreased from 61,9 % to 17 %.
Conclusion. The complex of modern investigational ophthalmological, laboratory and instrumental methods give the opportunity not only to diminish the proportion of undefined uveitis, but also to treat patients with more specific entities.