bluuebunny/crossref_metadata_2025_split huggingface dataset:
GreenLight HPS laser 120 W vs diode laser 300 W vaporization of the prostate for the treatment of benign prostatic hyperplasia in Japanese patients: A prospective, single‐center, randomized clinical trial
Authors: Kobayashi Takeshi , Seki Narihito , Song Yoo H. , Dejima Takashi 
Published: June 2020

AbstractObjectivesThis study aimed to compare the safety and efficacy of laser vaporization with 532 nm GreenLight High Performance System (HPS) laser 120 W (PVP) and 980 nm diode laser 300 W (CVP) for the treatment of benign prostatic hyperplasia (BPH) in a prospective, single‐center, randomized clinical trial.MethodsA total of 153 consecutive patients with symptomatic BPH were included; 79 patients were treated with PVP and 74 with CVP. Patients were assessed preoperatively and at 3, 6, and 12 months postoperatively using the International Prostate Symptom Score, quality of life index, peak urinary flow rate, and postvoid residual urine volume. All perioperative and postoperative complications were noted.ResultsThere were significant and comparable improvements in each of the outcome variables over a follow‐up period of 12 months in both groups. The mean operation/vaporization duration (minutes) was comparable at 74/38 (PVP) and 76/34 (CVP), whereas the mean applied laser energy was significantly higher with CVP than with PVP at 260 vs 195 (kJ), respectively. The mean vaporization rate (mL/min) was not significantly different between the two groups (0.53 PVP vs 0.56 CVP). Immediately after surgery, the rate of recatheterization for urinary retention was significantly higher with CVP than with PVP (17.6% vs 6.8%; P < 0.05).ConclusionsBoth laser systems provided comparable improvement in the subjective and objective parameters with excellent hemostatic properties. Although our results suggest that both procedures are useful treatment choices, further follow‐up is needed to draw definitive conclusions regarding the most ideal laser for treating patients with symptomatic BPH.
Intralesional steroid injection combined with bladder neck incision is efficacious in the treatment of recurrent bladder neck contracture
Authors: Mann Jordan A. , Silverman Joshua , Westenberg Andre 
Published: June 2020

AbstractObjectivesBladder neck contracture (BNC) is a well‐recognized complication following radical prostatectomy (RP). This problem may recur after failing initial endoscopic management. This study evaluated the efficacy of intralesional steroid injection combined with bladder neck incision (BNI) for recurrent BNC following RP.MethodsBetween November 2011 and March 2018, data from all men who underwent BNI and intralesional steroid injection for recurrent BNC from a single regional center were collected. BNC was diagnosed endoscopically and identified as recurrent if having previously failed endoscopic management with BNI alone. Follow up was initially performed at 3 months with an International Prostate Symptom Score and urinary flow rate. Patients were noted to be recurrence‐free when discharged from follow up or after having undergone a continence procedure indicating stability of the contracture.ResultsThirty patients underwent BNI and intralesional steroid injection for recurrent BNC over the study period. All patients had received prior endoscopic incision of BNC without lasting success. Seventy percent (21/30) of patients were recurrence‐free post‐procedure, and this increased to 83.3% (25/30) after a repeat procedure in four patients. All five patients who had previous salvage radiotherapy had their recurrent BNC successfully managed with one BNI and intralesional steroid injection. The mean follow up was 33.4 months (range 7‐75). There were no adverse events recorded.ConclusionsBNI combined with injection of intralesional steroids is a simple, cost‐effective intervention which requires no specialist equipment/skills outside the realm of a general urologist. It is safe and has an excellent success rate.
The biology of human overfeeding: A systematic review
Authors: Bray George A. , Bouchard Claude 
Published: June 2020

SummaryThis systematic review has examined more than 300 original papers dealing with the biology of overfeeding. Studies have varied from 1 day to 6 months. Overfeeding produced weight gain in adolescents, adult men and women and in older men. In longer term studies, there was a clear and highly significant relationship between energy ingested and weight gain and fat storage with limited individual differences. There is some evidence for a contribution of a genetic component to this response variability. The response to overfeeding was affected by the baseline state of the groups being compared: those with insulin resistance versus insulin sensitivity; those prone to obesity versus those resistant to obesity; and those with metabolically abnormal obesity versus those with metabolically normal obesity. Dietary components, such as total fat, polyunsaturated fat and carbohydrate influenced the patterns of adipose tissue distribution as did the history of low or normal birth weight. Overfeeding affected the endocrine system with increased circulating concentrations of insulin and triiodothyronine frequently present. Growth hormone, in contrast, was rapidly suppressed. Changes in plasma lipids were influenced by diet, exercise and the magnitude of weight gain. Adipose tissue and skeletal muscle morphology and metabolism are substantially altered by chronic overfeeding.
Can private governance boost public policy? Insights from public–private governance interactions in the fisheries and electricity sectors
Authors: Tzankova Zdravka 
Published: June 2020

AbstractBased on the inductive analysis of two parallel cases of private environmental governance – private, market‐driven fisheries governance and private, market‐driven governance for electricity decarbonization – this paper uncovers a trigger for positive public policy spillovers from private environmental governance. It identifies circumstances that prompt groups of business actors working as private regulators to also take on a role as public policy advocates and supporters, revealing a potential for private governance initiatives that are targeted at a particular environmental problem to serve as a bolster for the public regulatory governance of that problem as well. Both private governance cases at the basis of this analysis feature groups of business actors seeking to meet voluntary sustainability goals through the tools of private governance (specifically, through flexing buyer power and private authority in an effort to reform environmentally problematic practices among particular groups of suppliers). In both cases, the business's inability to attain private sustainability goals though private governance means alone has given rise to business demand for facilitative public environmental policy and regulation. The analysis presented in this paper thus points to the occurrence of a particular and intriguing pattern of complementarity between private authority and public policy – one where public policy is called on to fill gaps left by private environmental governance and authority. And it identifies key conditions for such private‐governance‐driven recentering of public policy to occur, namely the presence of private supply chain greening goals and commitments that are economically, reputationally, and/or competitively critical for businesses to attain, combined with shortfalls in the capacity of businesses' private authority to bring about such attainment. The two case analysis further suggests the importance of ENGOs in identifying and activating some of the opportunities for leveraging shortfalls in private environmental governance to the advantage of public environmental policy and regulation.
Is competition from China so special?
Authors: Heid Benedikt , Mínguez Raúl , Minondo Asier 
Published: June 2020

AbstractCompetition from China is perceived as particularly damaging. We study whether this is true for firm performance. Using the universe of Spanish export transactions, we find that an increase in competition from China does not have a more damaging effect on export revenues, prices and number of exported products than an equally sized increase in competition from other countries. We document, though, that Chinese competition raises the probability that a firm ceases to export a good to a destination more than competition from other countries. This effect declines over time. We document an omitted variable bias in studies focusing only on Chinese competition, even when controlling for unobserved heterogeneity of destinations for different products within firms.
Contrato de seguro. La obligación de información y agravación del riesgo cibernético
Authors: Campoy Adilson José , Malfatti Marcio Alexandre , Malfatti Michelle Sampaio Lopes , Rumstain Thaís De Cássia 
Published: June 2020

Brasil tiene leyes muy recientes que regulan el flujo de información que proporciona la tecnología, con reglas y consecuencias para aquellos que no cumplen, ya sea en el ámbito civil o penal. Sin embargo, el escenario mundial apunta a un aumento en el número de ataques cibernéticos y eso coloca a Brasil en una posición prominente en la vulnerabilidad a estos ataques. A partir de ahí, sigue la reflexión sobre el empeoramiento del riesgo en los contratos de seguro de responsabilidad y protección de datos cibernéticos y el deber de información inherente a todos los contratos de seguro.
Transformative Sport Service Research: Linking Sport Services With Well-Being
Authors: Inoue Yuhei , Sato Mikihiro , Filo Kevin 
Published: June 2020

The performance of sport organizations has been traditionally examined from the perspective of attaining strategic and operational goals (e.g., profitability, sporting performance). However, contemporary examples point to a need to expand sport organizations’ goals through consideration of their contributions to well-being outcomes. The current special issue addresses this need by advancing the theoretical and empirical understanding of transformative sport service research (TSSR), which seeks to understand how personal and collective well-being can be improved through a range of services offered in the sport industry. This introduction article clarifies the scope of TSSR scholarship and then provides a synthesis of findings and implications from the eight articles included in the special issue. The overview concludes with a call for collective efforts to establish a focused body of knowledge that leads sport organizations to integrate the goal of optimizing consumer and employee well-being into the core of their operations.
Identification of high-risk non-ST elevation myocardial infarction at presentation to emergency department. A prospective observational cohort study in North West England
Authors: Khand Aleem , Frost Freddy , Grainger Ruth , Fisher Michael , Chew Pei , Mullen Liam , Patel Billal , Obeidat Mohammed , Albouaini Khaled , Dodd James 
Published: June 2020

ObjectivesEarly access to invasive coronary angiography and revascularisation for high-risk non-ST elevation myocardial infarction (NSTEMI) improves outcomes and is supported by current guidelines. We sought to determine the most effective criteria at presentation to emergency department (ED) to identify high-risk NSTEMI.SettingSecondary care centre northwest England with national follow-up.Participants1642 consecutive patients (median age 59, 52% male) presenting to ED with a primary symptom of chest pain in whom there is suspicion of NSTEMI.Primary and secondary measuresMultivariate logistic regression analysis for the prediction of all-cause death (primary) and major adverse cardiac event (MACE defined as all-cause death, unplanned coronary revascularisation and adjudicated NSTEMI (third universal definition)) (secondary measure) at 1 year.ResultsThe incidence of adjudicated NSTEMI was 10.7%, and 1-year mortality was 6.3%. Independent predictors for all-cause death at 1 year were Global Registry of Acute Coronary Events (GRACE) >140, age (per decade increase) and high-sensitive cardiac troponin T (hs-cTnT) >50 ng/L. hs-cTnT >50 ng/L was associated with adjudicated index presentation NSTEMI in the greatest proportion of patients (61.7%). When using MACE at 12 months, as opposed to all-cause death, as an end point History, ECG, Age, Risk factors and Troponin (HEART) score ≥7 was included in the multivariate model and had better prediction of index NSTEMI than GRACE>140. Combining hs-cTnT >50 ng/L and a second independent predictor identified both a high proportion of index NSTEMI and elevated risk of all-cause death at 1 year.Conclusionshs-cTnT >50 ng/L or HEART score ≥7 appear effective strategies to identify high-risk NSTEMI at presentation to emergency room with chest pain. Multicentre prospective studies enriched with early presenters, and with competitor high-sensitive and point-of-care troponins, are required to validate and extend these findings.Trial registration numberNCT02581540.
Qualitative and quantitative approach to assess the potential for automating administrative tasks in general practice
Authors: Willis Matthew , Duckworth Paul , Coulter Angela , Meyer Eric T , Osborne Michael 
Published: June 2020

ObjectiveTo identify the extent to which administrative tasks carried out by primary care staff in general practice could be automated.DesignA mixed-method design including ethnographic case studies, focus groups, interviews and an online survey of automation experts.SettingThree urban and three rural general practice health centres in England selected for differences in list size and organisational characteristics.ParticipantsObservation and interviews with 65 primary care staff in the following job roles: administrator, manager, general practitioner, healthcare assistant, nurse practitioner, pharmacy technician, phlebotomist, practice nurse, pharmacist, prescription clerk, receptionist, scanning clerk, secretary and medical summariser; together with a survey of 156 experts in automation technologies.Methods330 hours of ethnographic observation and documentation of administrative tasks carried out by staff in each of the above job roles, followed by coding and classification; semistructured interviews with 10 general practitioners and 6 staff focus groups. The online survey of machine learning, artificial intelligence and robotics experts was analysed using an ordinal Gaussian process prediction model to estimate the automatability of the observed tasks.ResultsThe model predicted that roughly 44% of administrative tasks carried out by staff in general practice are ‘mostly’ or ‘completely’ automatable using currently available technology. Discussions with practice staff underlined the need for a cautious approach to implementation.ConclusionsThere is considerable potential to extend the use of automation in primary care, but this will require careful implementation and ongoing evaluation.
Impact of a work-based feedback intervention on student performance during clinical placements in acute-care healthcare settings: a quasi-experimental protocol for the REMARK programme
Authors: Ossenberg Christine , Mitchell Marion , Henderson Amanda 
Published: June 2020

IntroductionCurrent perspectives present feedback as a dynamic, dialogic process. It is widely accepted that feedback can have an impact on workplace performance, however, how dialogic feedback is enacted with the learner in authentic healthcare settings is less apparent. This paper seeks to describe the design and development of an implementation study to promote the learner voice in the feedback process and improve feedback encounters between learners and learning partners in healthcare settings.Methods and analysisA quasi-experimental study design will be used to evaluate whether implementation of a work-based intervention to improve feedback impacts student performance during clinical placements in healthcare settings. Student performance will be measured at three time points: baseline (pre), mid-placement (post-test 1) and end-placement (post-test 2) in keeping with standard assessment processes of the participating university. The intervention is underpinned by Normalisation Process Theory and involves a layered design that targets learners and learning partners using best-practice education strategies. Data regarding participants’ engagement with feedback during clinical placements and participants’ level of adoption of the intervention will be collected at the completion of the clinical placement period.Ethics and disseminationThis study has ethics approval from both Griffith University and Metro South Health Human Research and Ethics committees. Dissemination of results will be local, national and international through forums, seminars, conferences and publications.
Development of ARCADIA: a tool for assessing the quality of peer-review reports in biomedical research
Authors: Superchi Cecilia , Hren Darko , Blanco David , Rius Roser , Recchioni Alessandro , Boutron Isabelle , González José Antonio 
Published: June 2020

ObjectiveTo develop a tool to assess the quality of peer-review reports in biomedical research.MethodsWe conducted an online survey intended for biomedical editors and authors. The survey aimed to (1) determine if participants endorse the proposed definition of peer-review report quality; (2) identify the most important items to include in the final version of the tool and (3) identify any missing items. Participants rated on a 5-point scale whether an item should be included in the tool and they were also invited to comment on the importance and wording of each item. Principal component analysis was performed to examine items redundancy and a general inductive approach was used for qualitative data analysis.ResultsA total of 446 biomedical editors and authors participated in the survey. Participants were mainly male (65.9%), middle-aged (mean=50.3, SD=13) and with PhD degrees (56.4%). The majority of participants (84%) agreed on the definition of peer-review report quality we proposed. The 20 initial items included in the survey questionnaire were generally highly rated with a mean score ranging from 3.38 (SD=1.13) to 4.60 (SD=0.69) (scale 1–5). Participants suggested 13 items that were not included in the initial list of items. A steering committee composed of five members with different expertise discussed the selection of items to include in the final version of the tool. The final checklist includes 14 items encompassed in five domains (Importance of the study, Robustness of the study methods, Interpretation and discussion of the study results, Reporting and transparency of the manuscript, Characteristics of peer reviewer’s comments).ConclusionAssessment of Review reports with a Checklist Available to eDItors and Authors tool could be used regularly by editors to evaluate the reviewers’ work, and also as an outcome when evaluating interventions to improve the peer-review process.
Characteristics of registered clinical trials assessing treatments for COVID-19: a cross-sectional analysis
Authors: Mehta Hemalkumar B , Ehrhardt Stephan , Moore Thomas J , Segal Jodi B , Alexander G Caleb 
Published: June 2020

ObjectivesThe coronavirus disease 2019 (COVID-19) pandemic has prompted many initiatives to identify safe and efficacious treatments, yet little is known regarding where early efforts have focused. We aimed to characterise registered clinical trials assessing drugs or plasma treatments for COVID-19.Design, setting and participantsCross-sectional analysis of clinical trials for the treatment of COVID-19 that were registered in the USA or in countries contributing to the WHO’s International Clinical Trials Registry Platform. Relevant trial entries of drugs or plasma were downloaded on 26 March 2020, deduplicated, verified with reviews of major medical journals and WHO websites and independently analysed by two reviewers.Main outcome(s)Trial intervention, sponsorship, critical design elements and specified outcomesResultsOverall, 201 clinical trials were registered for testing the therapeutic benefits of 92 drugs or plasma, including 64 in monotherapy and 28 different combinations. Only eight (8.7%) products or combinations involved new molecular entities. The other test therapies had a wide range of prior medical uses, including as antivirals, antimalarials, immunosuppressants and oncology treatments. In 152 trials (75.7%), patients were randomised to treatment or comparator, including 55 trials with some form of blinding and 97 open-label studies. The 49 (24.4%) of trials without a randomised design included 29 single armed studies and 20 trials with some comparison group. Most trial designs featured multiple endpoints. Clinical endpoints were identified in 134 (66.7%) of trials and included COVID-19 symptoms, death, recovery, required intensive care and hospital discharge. Clinical scales were being used in 33 (16.4%) trials, most often measures of oxygenation and critical illness. Surrogate endpoints or biomarkers were studied in 88 (42.3%) of trials, primarily assays of viral load. Although the trials were initiated in more than 17 countries or regions, 100 (49.8%) were registered in China and 78 (37.8%) in the USA. Registered trials increased rapidly, with the number of registered trials doubling from 1 March to 26 March 2020.ConclusionsWhile accelerating morbidity and mortality from the COVID-19 pandemic has been paralleled by early and rapid clinical investigation, many trials lack features to optimise their scientific value. Global coordination and increased funding of high-quality research may help to maximise scientific progress in rapidly discovering safe and effective treatments.
Real-world insight into public access defibrillator use over five years
Authors: Torney Hannah , McAlister Olibhéar , Harvey Adam , Kernaghan Amy , Funston Rebecca , McCartney Ben , Davis Laura , Bond Raymond , McEneaney David , Adgey Jennifer 
Published: June 2020

BackgroundPublic access defibrillators (PADs) represent unique life-saving medical devices as they may be used by untrained lay rescuers. Collecting representative clinical data on these devices can be challenging. Here, we present results from a retrospective observational cohort study, describing real-world PAD utilisation over a 5-year period.MethodsData were collected between October 2012 and October 2017. Responders voluntarily submitted electronic data downloaded from HeartSine PADs, and patient demographics and other details using a case report form in exchange for a replacement battery and electrode pack.ResultsData were collected for 977 patients (692 males, 70.8%; 255 females, 26.1%; 30 unknown, 3.1%). The mean age (SD) was 59 (18) years (range <1 year to 101 years). PAD usage occurred most commonly in homes (n=328, 33.6%), followed by public places (n=307, 31.4%) and medical facilities (n=128, 13.1%). Location was unknown in 40 (4.09%) events. Shocks were delivered to 354 patients. First shock success was 312 of 350 patients where it could be determined (89.1%, 95% CI 85.4% to 92.2%). Patients with reported response times ≤5 min were more likely to survive to hospital admission (89/296 (30.1%) vs 40/250 (16.0%), p<0.001). Response time was unknown for 431 events.ConclusionThis is the first study to report global PAD usage in voluntarily submitted, unselected real-world cases and demonstrates the real-world effectiveness of PADs, as confirmed by first shock success.