bluuebunny/crossref_metadata_2025_split huggingface dataset:
First-year students’ communication apprehension in learning French as foreign language
Authors: Darmawangsa Dante , Sukmayadi Vidi , Yahya Azizul Halim 
Published: October 2020

Learning a foreign language and being first-year students at the same time can be challenging as they struggle to make the transition in learning a new language and adjusting to their new lives as a university student. Students have to deal with not only the academic challenges but also the adaptation challenge since they are making a transition to their new day to day life on campus. One of the significant challenges students frequently faces as a foreign language learner is a lack of communication confidence, which can turn into a hampering factor for their academic achievements. This mixed-methods study aimed to examine students’ communication apprehension (CA) level and explore factors that contributed to their current level of CA. In this paper, the authors measured the level of CA in 57 first-year students of French Language departments in an Indonesian university. Quantitative data was analysed via McCroskey’s Personal Report of Communication Apprehension (PRCA-24). Qualitative questions explored how the first-year students perceived their senses of experiencing the communication apprehension. In addition, the qualitative thematic analysis was utilised to analyse the qualitative data. The findings indicated a moderate level of CA in most of the first-year studentssuch as fear of negative evaluation which was considered as the leading cause of the students’ high level of anxiety., Meanwhile, while prior knowledge and a supportive teacher-student relations were appraised as the main foundation of the low level of CA students.
Construing The Great Fire of London through online media: A case of exploring discourse semantics and register
Authors: Bangga Lungguh Ariang 
Published: October 2020

This paper considers the exploration of genre and register of historical texts recontextualised in online media and school textbooks through the lens of Systemic Functional Linguistics especially by exploring their discourse semantics and register features. Particularly, this paper shows how the relation between discourse semantics resources and register variables contribute to the overall organisation of the recontextualized history genres. This paper provides a detailed qualitative analysis of discourse semantics as instantiated in the deployment of APPRAISAL, IDEATION, IDENTIFICATION, and PERIODICITY to give a clearer picture of how history genres in the media are established. A set of corpora consisting of historical texts from online media and school textbooks was used as a main source of data in this study. The historical texts collected from online media were from various platforms including online newspapers, online magazines, encyclopaedia entries, and universities websites/blogs. For the illustrative purposes, two texts from the corpora were selected for a detailed analysis using the discourse semantics toolkits to find out similarities and differences in terms how an historical event – The Great Fire of London – was established. The analysis found that there was a tendency that historical events could be reconstrued in the media through different ways. The first text informs readers about the fire and its significance in a chronological manner. The second text provides an explanation of the influence of the Great Fire to other historical events. This paper also suggests that history genres tend to be ‘evolving’ as reproduced in varied media discourses. Though still at the infancy stage, this paper offers a great insight into how genres are organised in relation to the choices in register variables and discourse semantics.
NOA Demonstratoren Special
Authors: Nothdurft Lars , Epple Ulrich , Schröder Tizian , Diedrich Christian , Grossmann Daniel , Banerjee Suprateek , Schmied Sebastian , Iatrou Chris Paul , Graube Markus , Urbas Leon , Henrichs Tim Peter , Erben Stefan 
Published: October 2020

Bei der Namur-Hauptsitzung 2016 wurde erstemals die im Namur-Arbeitskreis 2.8 "Automatisierungsnetzwerke und -dienste" entwickelte Namur Open Architecture (NOA) vorgestellt. Mit NOA wird der Versuch unternommen, die bestehenden Automatisierungsstrukturen so zu öffnen und zu ergänzen, dass Innovationen (IoT, Industrie 4.0 und andere) nutzbar werden, ohne die Vorteile der bisherigen Automatisierung zu verlieren. Vier Hochschulen stellten ein Jahr später, bei der Namur-Hauptsitzung 2017, nun erstmals vier Demonstratoren vor, bei denen NOA praktisch umgesetzt wurde. Die Hauptbeiträge der atp edition 1-2/2018 stellen diese vor:Plug-and-Produce-Prozess mit NOA automatisierenLars Nothdurft, Ulrich Epple, RWTH AachenNOA schafft Voraussetzungen für neue digitale DiensteTizian Schröder, Christian Diedrich, Otto-von-Guericke-Universität MagdeburgFeldgerätedaten mit NOA in Cloud-Applikationen nutzenDaniel Grossmann, Suprateek Banerjee, Sebastian Schmied, Technische Hochschule IngolstadtNOA Verification of RequestChris Paul Iatrou, Markus Graube, Leon Urbas, Technische Universität DresdenTim-Peter Henrichs, Yokogawa DeutschlandStefan Erben, Samson
Computational studies of some benzothiazinone-pepirazine derivatives and lipase b inhibitor for mycobacterium tuberculosis
Authors: Muhammad Yakubu Ya'u , Uzairu Adamu 
Published: October 2020

Computational technique was employed on Benzothiazinone-pepirazine derivatives as dominant anti-mycobacterium tuberculosis. The compound structures were drawn with the aid of chemdraw 3D Pro 12.1.0V and optimized was employed using DFT method applying B3LYP with the 6-31G? basis set. Genetic Function Approximation (GFA) was employed to form five models. Model 1 was sorted out based on model validation parameters and found to be significant with R2 value of 0.948605, R2adj(adjusted correlation coefficient) value of 0.934329, QLoo(Cross validation coefficient) value 0.892724 and R2pred value of 0.658537. The docking studies showed that the ligand 6, 7 and 18 has the highest binding affinities of 10.5, 10.4, 10.3 k/mole are the most vital compounds among the binding scores. Ligand 6 being among the ligands with the highest binding affinity (-10.5 k/mole) was found to be more potent than other compounds. Stability and Robustness the model highlight the way for designing latest Benzothiazinone-pepirazine analogue with better activity against mycobacterium tuberculosis.
The Structure of the Membrane Protein of SARS-CoV-2 Resembles the Sugar Transporter SemiSWEET
Authors: Thomas Sunil 
Published: October 2020

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the disease COVID-19 that has decimated the health and economy of our planet. The virus causes the disease not only in people but also in companion and wild animals. People with diabetes are at risk of the disease. As yet we do not know why the virus has been highly successful in causing the pandemic within 3 months of its first report. The structural proteins of SARS include membrane glycoprotein (M), envelope protein (E), nucleocapsid protein (N), and the spike protein (S). Methods: The structure and function of the most abundant structural protein of SARS-CoV-2, the membrane (M) glycoprotein, is not fully understood. Using in silico analyses we determined the structure and potential function of the M protein. Results: The M protein of SARS-CoV-2 is 98.6% similar to the M protein of bat SARS-CoV, maintains 98.2% homology with pangolin SARS-CoV, and has 90% homology with the M protein of SARS-CoV; whereas, the similarity is only 38% with the M protein of MERS-CoV. In silico analyses showed that the M protein of SARS-CoV-2 has a triple helix bundle, forms a single 3-transmembrane domain, and is homologous to the prokaryotic sugar transport protein SemiSWEET. SemiSWEETs are related to the PQ-loop family whose members function as cargo receptors in vesicle transport, mediate movement of basic amino acids across lysosomal membranes, and are also involved in phospholipase flippase function. Conclusions: The advantage and role of the M protein having a sugar transporter-like structure is not clearly understood. The M protein of SARS-CoV-2 interacts with S, E, and N protein. The S protein of the virus is glycosylated. It could be hypothesized that the sugar transporter-like structure of the M protein influences glycosylation of the S protein. Endocytosis is critical for the internalization and maturation of RNA viruses, including SARS-CoV-2. Sucrose is involved in endosome and lysosome maturation and may also induce autophagy, pathways that help in the entry of the virus. Overall, it could be hypothesized that the SemiSWEET sugar transporter-like structure of the M protein may be involved in multiple functions that may aid in the rapid proliferation, replication, and immune evasion of the SARS-CoV-2 virus. Biological experiments would validate the presence and function of the SemiSWEET sugar transporter.
Transient Diagnosis of Fines Migration Integrating Core Testing and Numerical Reservoir Modeling
Authors: Pan Yan , Manley Timothy S. , Li Yan , Karazincir Oya A. , Descant Frank , Williams Wade 
Published: October 2020

SummaryTo manage well productivity, an effort was undertaken to identify fines migration by means of transient diagnosis, quantify its effect on productivity, model the production history, and forecast well performance. Because of its distinguishable transient behavior, mechanical fines migration can be identified among other factors that contribute to productivity decline. Pressure transient analysis (PTA), production data analysis (PDA), laboratory experiments, and numerical-flow-simulation techniques were used to understand the physics of fines migration, quantify its characteristic parameters, validate the model with production history, and verify its efficacy in a field application. Results are consistent with laboratory observations, synthetic studies leveraging a geomechanics reservoir simulator, and field data for moderate to severe fines migration.A new integrated approach was developed to accurately identify and depict declining productivity caused by fines migration through PTA, core testing, and reservoir flow modeling. Previous research has proposed a permeability-reduction flow function that correlates with extended coreflood data to predict the key parameters that characterize the fines-migration effects: critical velocity, permeability-reduction rate, and ultimate residual permeability. From the transient-behavior observations on wells experiencing fines migration, the obvious damage is represented by a positive skin as a function of time in the near-wellbore region. This concurs with the realization that interstitial velocity decreases with the distance from the wellbore. For severe fines migration observed in both synthetic cases and field data, two permeability regions could be identified and described by a radial composite model allowing the damage radius and the average permeabilities of each zone be estimated. Incorporation of a new technique, which correlates the skin-time function with the fines-migration flow relation, enables the calculation of key parameter ranges. These can be integrated with coreflood data for use as initial values in numerical reservoir modeling, potentially simplifying history-matching efforts before performance forecast.The novelty of this workflow is in the ability to identify and quantify the potential influence of mechanical fines migration with PTA and PDA techniques, and incorporation of the fines-migration flow relation to estimate the ranges of the characteristic parameters used in numerical modeling. Understanding the impact of fines migration on well productivity allows engineers to more accurately predict production decline, identify the benefit of remediation, and select optimal development strategies.
Quantification ofSorReduction during Polymer Flooding Using Extensional Capillary Number
Authors: Azad Madhar Sahib , Trivedi Japan J. 
Published: October 2020

SummarySince the introduction of viscous/capillary concepts by Moore and Slobod (1956), several modifications and advancements have been made to the capillary number (Nc) so that it could have a better correlation with residual oil saturation (Sor) during enhanced oil recovery (EOR). In subsequent years, laboratory-scale studies have indicated that the viscoelastic polymers can influence the Sor reduction at relatively higher fluxes and Nc. Although the flux rate of at least 1 ft/D is reported to be needed for viscoelastic polymers to reduce Sor to a noticeable extent, significant Sor reductions were reported to occur only at higher fluxes that are likely to be seen in the reservoir closer to the wellbore. At similar levels of flux and Nc, the polymer solutions with significant elastic properties have shown higher Sor reduction than viscous polymer of similar shear rheology. However, the existing models used for correlating the polymer’s viscoelastic effect on Sor reduction relies on either core-scale Nc and/or the oscillatory Deborah number (De). De also has limitations in quantifying the polymer’s viscoelastic effects at different salinities.In this paper, a modified capillary number called an extensional capillary number (Nce) is developed using the localized pore-scale extensional viscosity. For viscoelastic polymer solutions, pore-scale apparent viscosity dominated by localized extensional viscosity is calculated to be significantly higher than core-scale apparent viscosity. We provide rheological insights using the variable-strain-rate concept to explain why and when the pore-scale apparent viscosity could become significantly higher, even at a flux of approximately 1 to 4 ft/D, and why it will not be reflected on the core-scale apparent viscosity or pressure drop. An exponential correlation was developed between Nce and Sor using the extensive coreflood experimental data sets extracted from various literature. Performance of Nce for predicting the viscoelastic polymer’s residual oil recovery is compared with conventional Nc, De, and a recent correlation. The results show that newly developed Nce can predict the Sor during polymer flooding for a wide range of operational and petrophysical conditions, including brine-salinity effects.
End-of-life care for people with advanced dementia and pain: A qualitative study in Swedish nursing homes
Authors: Lundin Emma , Godskesen Tove 
Published: October 2020

Abstract
Background Of the Swedish people with advanced dementia, the majority die in nursing homes. Unresolved pain can occur in people with a terminal illness such as dementia. However, pain management in people with advanced dementia is often suboptimal and inadequate, with fewer palliative care interventions than offered to cancer patients. Although they are largely responsible for the care of these people, few studies have addressed the experiences of registered nurses in this respect. Therefore, the aim of this study was to describe the experiences of nurses in caring for people with advanced dementia and pain at the end of life.Methods The study had a descriptive explorative design. Individual qualitative, semi-structured interviews were carried out with thirteen nurses from twelve nursing homes in Sweden. The results were analysed using thematic content analysis.Results The nurses described communicative, relational and organisational challenges. One major issue involved difficulties in communicating with the person with advanced dementia, resulting in uncertain pain assessment. Other difficulties involved the differentiation of pain from anxiety, the balance of benefits and risks with morphine administration, and the creation of good relationships with healthcare personnel and the persons’ relatives. Relatives can greatly affect the assessment and management of pain, both because of their ability to interpret pain behaviour and by questioning the care given. Good pain management was facilitated by good communication and relationships with healthcare staff and relatives, extensive professional nursing experience, and already knowing the person with advanced dementia.Conclusions This study highlights the need for nursing homes to employ specialist nurses who have been trained in the appropriate knowledge and skills to deal with the challenges of end-of-life care for people with advanced dementia and pain. Additionally, there should be resources and strategies available for providing information to family members and for involving them in the decision-making process, as they are often unfamiliar with the multitude of considerations involved in decisions such as whether to administer morphine or not.
Knowledge About Diabetic Retinopathy, Eye Check-Up Practice And Associated Factors Among Adult Patients With Diabetes Mellitus Attending At Debark Hospital, Northwest Ethiopia
Authors: Tegegne Mebratu Muusew , Assem Abel Sinshaw , Alemu Destaye Shiferaw , Woredekal Asamere Tsegaw , Tefera Tsehay Kassa 
Published: October 2020

Abstract
Background:Routine eye examination plays a vital role in detecting diabetic retinopathy in its earliest stage before the onset of blindness. Patients’ knowledge about the nature and the consequences of diabetic retinopathy and routine eye checkup helps in timely identification and early treatment. However, there is limited evidence on knowledge of patients with diabetes mellitus on diabetic retinopathy and their eye check-up practices in Ethiopia.The aim of this study was to assess knowledge, eye check-up practice and associated factors of diabetic retinopathy among adult diabetic patients at Debark hospital, Northwest Ethiopia.Methods: Institution based cross – sectional study was conducted at Debark hospital, Northwest Ethiopia, from April 20/2018- May 20/2018. A pretested interviewer administered structured questionnaire was used to collect data among 230 diabetic patients aged 18 years and above. Data were entered in to Epi Info version 7 and exported to SPSS version 20 for analysis. Bivariable and multivariable binary logistic regression analyses were done. Odds ratio with 95% confidence level was determined and variables with p–value of < 0.05 were considered as statistically significant.Result: Out of 238 sample 230 were participated, among this, 119 (51.7%) were males. The mean age of the respondents was 49 (SD ±17.6) years. One hundred nine (47.4%) participants had good knowledge and 91 (39.6%) had good eye check-up practice. Urban residence [AOR= 2.65;95% CI: 1.16-6.07)]), monthly income of 3501-8000 birr [AOR=4.54;(1.31-15.7)], type II diabetes mellitus [AOR=3.9;(1.6-9.6)], duration of diabetes (6-12 years[AOR=4.4;(1.4-13.5)]), history of eye disease [AOR=5.5;(2.3-13.0)] were associated with good knowledge. Similarly, longer duration of diabetes (13-25 years [AOR=3.77; (1.05-13.5)]) and history of eye disease [AOR=2.47; (1.09-5.62)] were associated with good eye check-up practice. Conclusion: The proportion of good knowledge about diabetic retinopathy among diabetic patients at Debark hospital was fair (47.4%) and good eye check-up practice (eye examination at least once in the past year) was low (39.6%). Longer duration of diabetes and history of eye disease were identified as positive factors for good knowledge and eye check-up practice. Knowledge and regular eye check-up practice needs to be enhanced through provision of appropriate health education.
Increased Association of Deamidated αA-N101D with Lens Membrane of Transgenic αAN101D vs. Wild Type αA Mice: Potential Effects on Intracellular Ionic Imbalance and Membrane Disorganization
Authors: Srivast Om , Srivast Kiran , Joseph Roy , Wilson Landon 
Published: October 2020

Abstract
We have generated two mouse models, in one by inserting the human lens αAN101D transgene in CRYαAN101D mice, and in the other by inserting human wild-type αA-transgene in CRYαAWT mice. The CRYαAN101D mice developed cortical cataract at about 7-months of age relative to CRYαAWT mice. The objective of the study was to determine the following relative changes in the lenses of CRYαAN101D- vs. CRYαAWT mice: age-related changes with specific emphasis on protein insolubilization, relative membrane-association of αAN101D vs. WTαA proteins, and changes in intracellular ionic imbalance and membrane organization. Methods: Lenses of varying ages from CRYαAWT and CRYαAN101D mice were compared for an age-related protein insolubilization. The relative lens membrane-association of the αAN101D- and WTαA proteins in the two types of mice was determined by immunohistochemical-, immunogold-labeling-, and western blot analyses. The relative levels of membrane-binding of recombinant αAN101D- and WTαA proteins was determined by an in vitro assay, and the levels of intracellular Ca2+ uptake and Na, K-ATPase mRNA were determined in the cultured epithelial cells from lenses of the two types of mice.Results: Compared to the lenses of CRYαAWT, the lenses of CRYαAN101D mice exhibited: (A) An increase in age-related protein insolubilization beginning at about 4-months of age. (B) A greater lens membrane-association of αAN101D- relative to WTαA protein during immunogold-labeling- and western blot analyses, including relatively a greater membrane swelling in the CRYαAN101D lenses. (C) During in vitro assay, the greater levels of binding αAN101D- relative to WTαA protein to membranes was observed. (D) The 75% lower level of Na, K-ATPase mRNA but 1.5X greater Ca2+ uptake was observed in cultured lens epithelial cells of CRYαAN101D- than those of CRYαAWT mice. Conclusions: The results show that an increased lens membrane association of αAN101D--relative WTαA protein in CRYαAN101D mice than CRYαAWT mice occurs, which causes intracellular ionic imbalance, and in turn, membrane swelling that potentially leads to cortical opacity.