bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bilinear approach to supersymmetric AKNS system; multiple dressing of fermionic amplitudes
Authors: Babalic Corina N. , Carstea A. S. 
Published: June 2020

In this paper, we investigate the super-bilinear formalism and interaction of supersoliton solutions for the supersymmetric AKNS system [H. Aratyn and A. Das, Mod. Phys. Lett. A 13, 1185 (1998)]. It is shown that the super-bilinear form involves an auxiliary fermionic tau function and the supersolitons have less freedom than expected (concerning the dependence on fermionic parameters). Also, the interaction between super-solitons is much more complicated than in the case of real supersymmetric equations (KdV, mKdV, Sawada–Kotera, Sine–Gordon, etc.), involving four types of dressing of the fermionic parameters. These solutions are general compared to the ones found in Ref. 1 which contain no fermionic parameter.
Design for tunable optofluidic optical coupler with large dynamic range
Authors: Tang Xionggui , Meng Fang 
Published: June 2020

A novel scheme for tunable optofluidic optical coupler is proposed by combining directional coupling waveguide structures with microfluidic channel. The normalized optical power at two output ports can be dynamically manipulated by controlling the refractive index of liquid mixture in microfluidic channel. Its optical performance is numerically investigated by employing the beam propagation method (BPM). The simulated results show that the dynamic range of over 45 dB, and optical loss of below 0.06 dB can be easily achieved, and furthermore the dependence of polarization states and operation wavelength in the range from 1500 nm to 1600 nm are very low in our designed device. In addition, the tunable optofluidic coupler has advantages including simple structure and large fabrication tolerance. Accordingly, our proposed device offers a new approach for manipulating optical power output, which has wide potential application in optofluidic systems.
Exploration play statistics in the central–northern North Sea region of UK–Norway–Denmark
Authors: Quirk David G. , Archer Stuart G. 
Published: June 2020

Abstract

The central–northern North Sea region represents one of the richest and most diverse petroleum basins in the world. This paper presents an analysis of the historical results of exploration in the Central Graben, Outer Moray Firth and Viking Graben, plus surrounding regions, including West of Shetlands. The richness and maturity of the main late Jurassic source rock accounts for almost 100 billion barrels of oil equivalent (boe) recoverable resource in the three North Sea rift arms in reservoirs as old as Devonian and as young as Quaternary. Within a contiguous area of 100 000 km
2
, 29 different proven part plays (area-confined, deposition-specific stratigraphic intervals or play segments) have been analysed in detail. These range in age from Triassic to Eocene, representing 717 discoveries with a total of 78.1 billion boe recoverable resource present in primary reservoirs. The most prolific plays in terms of total resource found are Mid Jurassic paralic sandstones (in the Viking Graben), Upper Cretaceous chalk (in the Central Graben) and Paleocene turbidite sandstones (in all three rift arms). The average discovery rate (historical chance of geological success) across all the plays is 44% with a relatively low variance. No significant improvement is seen in success rate over the last 50 years, despite increased well density, knowledge and huge advances in geophysical data. Of the discoveries, 404 are commercial fields representing 57% of all discoveries but the rate has decreased to 33% over the last 10 years, as average discovery sizes have decreased significantly. Discovery size is highly variable (10 to more than 600 MMboe) but the historical average is 114 MMboe, a world-class value. Dividing discovery recoverable resource size by footprint area produces a useful measure of reservoir yield, MMboe/km
2
, and the median value for the different part plays varies from 1.3 MMboe/km
2
for an Eocene turbidite to 5.3 MMboe/km
2
for a Jurassic turbidite.

From a global perspective, the North Sea is not only unusual in the volume of petroleum, diversity of reservoirs and size of discoveries but also for its number of overlapping part plays and for the fact that the largest volume of total resource is found in reservoirs older than the source rock, syn-rift sandstones having been charged from an end-of-rift marine shale.
Provenance of the Miocene Nanchital conglomerate, western Chiapas Foldbelt, Mexico: implications for reservoir sands in the Sureste Basin, Greater Campeche Province
Authors: Pindell James , Molina-Garza Roberto , Villagómez Diego , Martens Uwe , Graham Rod , Stockli Daniel , Weber Bodo , Sierra-Rojas María Isabel 
Published: June 2020

Abstract
The Miocene Nanchital conglomerate of the western Chiapas Foldbelt is the coarsest terrigenous clastic depositional Cenozoic unit of the region, probably comprising more proximal sections of hydrocarbon-rich slope-fan reservoirs found in the more distal Sureste Basin of the southern Gulf of Mexico fringe. Traditionally, the felsic igneous and metamorphic components of the conglomerate were assumed to derive from the Permian basement of the nearby Chiapas Massif. However, zircon U–Pb dating of five Nanchital conglomerate clasts from the Chiapas Foldbelt as well as several igneous exposures in SW Tehuantepec indicates that the Nanchital conglomerate's catchment area included the western Isthmus of Tehuantepec for late Middle Miocene and possibly early Late Miocene time, after which the more proximal Chiapas Massif and Chiapas Foldbelt likely became dominant. This study suggests that traditional concerns over the limited extent of quartz-rich clastic source areas feeding terrigenous clastic reservoirs in the Sureste Basin might be overly pessimistic. We propose a temporal framework for viewing Neogene and Quaternary clastic supply to the southern Gulf of Mexico.
Scalable Application- and User-aware Resource Allocation in Enterprise Networks Using End-Host Pacing
Authors: Sieber Christian , Schwarzmann Susanna , Blenk Andreas , Zinner Thomas , Kellerer Wolfgang 
Published: June 2020

Providing scalable user- and application-aware resource allocation for heterogeneous applications sharing an enterprise network is still an unresolved problem. The main challenges are as follows: (i) How do we define user- and application-aware shares of resources? (ii) How do we determine an allocation of shares of network resources to applications? (iii) How do we allocate the shares per application in heterogeneous networks at scale? In this article, we propose solutions to the three challenges and introduce a system design for enterprise deployment.
Defining the necessary resource shares per application is hard, as the intended use case, the user’s environment, e.g., big or small display, and the user’s preferences influence the resource demand. We tackle the challenge by associating application flows with utility functions from subjective user experience models, selected Key Performance Indicators, and measurements. The specific utility functions then enable a mapping of network resources in terms of throughput and latency budget to a common user-level utility scale. A sensible distribution of the resources is determined by formulating a multi-objective mixed integer linear program to solve the throughput- and delay-aware embedding of each utility function in the network for a max-min fairness criteria. The allocation of resources in traditional networks with policing and scheduling cannot distinguish large numbers of classes and interacts badly with congestion control algorithms. We propose a resource allocation system design for enterprise networks based on Software-Defined Networking principles to achieve delay-constrained routing in the network and application pacing at the end-hosts.
The system design is evaluated against best effort networks in a proof-of-concept set-up for scenarios with increasing number of parallel applications competing for the throughput of a constrained link. The competing applications belong to the five application classes web browsing, file download, remote terminal work, video streaming, and Voice-over-IP. The results show that the proposed methodology improves the minimum and total utility, minimizes packet loss and queuing delay at bottlenecks, establishes fairness in terms of utility between applications, and achieves predictable application performance at high link utilization.
Effectiveness of Neural Networks for Power Modeling for Cloud and HPC
Authors: Costa Georges DA , Pierson Jean-Marc , Fontoura-Cupertino Leandro 
Published: June 2020

Power consumption of servers and applications are of utmost importance as computers are becoming ubiquitous, from smart phones to IoT and full-fledged computers. To optimize their power consumption, knowledge is necessary during execution at different levels: for the Operating System to take decisions of scheduling, for users to choose between different applications.
Several models exist to evaluate the power consumption of computers without relying on actual wattmeters: Indeed, these hardware are costly but also usually have limits on their pooling frequency (usually a one-second frequency is observed) except for dedicated professional hardware. The models link applications behavior with their power consumption, but up to now there is a 5% wall: Most models cannot reduce their error under this threshold and are usually linked to a particular hardware configuration.
This article demonstrates how to break the 5% wall of power models. It shows that by using neural networks it is possible to create models with 1% to 2% error. It also quantifies the reachable precision obtainable with other classical methods such as analytical models.
Complexity of Unordered CNF Games
Authors: Rahman Md Lutfar , Watson Thomas 
Published: June 2020

The classic TQBF problem is to determine who has a winning strategy in a game played on a given conjunctive normal form formula (CNF), where the two players alternate turns picking truth values for the variables in a given order, and the winner is determined by whether the CNF gets satisfied. We study variants of this game in which the variables may be played in any order, and each turn consists of picking a remaining variable and a truth value for it.
For the version where the set of variables is partitioned into two halves and each player may only pick variables from his or her half, we prove that the problem is PSPACE-complete for 5-CNFs and in P for 2-CNFs. Previously, it was known to be PSPACE-complete for unbounded-width CNFs (Schaefer, STOC 1976). For the general unordered version (where each variable can be picked by either player), we also prove that the problem is PSPACE-complete for 5-CNFs and in P for 2-CNFs. Previously, it was known to be PSPACE-complete for 6-CNFs (Ahlroth and Orponen, MFCS 2012) and PSPACE-complete for positive 11-CNFs (Schaefer, STOC 1976).
Prognosis of Patients with Colorectal Cancer with Diabetes According to Medication Adherence: A Population-Based Cohort Study
Authors: Choe Sunho , Lee Joonki , Park Ji Won , Jeong Seung-Yong , Cho Young Min , Park Byung-Joo , Shin Aesun 
Published: June 2020

Abstract

Background:
Diabetes mellitus is known to have a negative effect on colorectal cancer survival due to hyperinsulinemia or hyperglycemia, and medications such as metformin, which targets insulin resistance and hyperinsulinemia, have a preventive effect on the risk of death. The aim of this study was to compare the risk of death among patients with colorectal cancer with diabetes with different levels of adherence to oral antidiabetics.

Methods:
National Health Information Database was used, which has all claims data for those who are registered for national health insurance in Korea, from 2002 to 2016, for conducting a retrospective cohort study. Newly diagnosed patients with colorectal cancer among diabetics were followed up from the date of diagnosis until death or December 31, 2016. The medication adherence was calculated as the proportion of days covered (PDC). The HR and 95% confidence interval (CI) for death were estimated using the low-adherence patients as a reference.

Results:
A total of 33,841 diabetic patients with newly diagnosed colorectal cancer were followed for an average of 4.7 years. Patients with colorectal cancer with good adherence (PDC ≥ 80%) showed a reduced risk of death [HR (95% CI), 0.82 (0.78–0.86)] compared with those with poor adherence (PDC &lt; 80%). A reduced risk of death was observed for all cancer subsites.

Conclusions:
The maintenance of good medication adherence for diabetes mellitus was related to a favorable prognosis of colorectal cancer.

Impact:
This study provides evidence that patients with colorectal cancer who are adherent to their diabetes medication will have better survival than patients who are not adherent.
Splice of Life for Cancer: Missplicing of PPP2R5A by Mutant SF3B1 Leads to MYC Stabilization and Tumorigenesis
Authors: O'Connor Caitlin M. , Narla Goutham 
Published: June 2020

Abstract

Summary:
Although mutations in SF3B1 are the most common RNA-splicing factor mutations in cancer, determining the downstream missplicing events that drive tumorigenesis has remained challenging. Liu and colleagues present a model by which mutant SF3B1 tumors displayed high levels of oncogenic MYC activity through the missplicing of PP2A-B56α, a key post-translational regulator of MYC stability, providing a new therapeutic target and driver of SF3B1-mediated tumorigenesis.
See related article by Liu et al., p. 806.
Randomized Pragmatic Trial of Stroke Transitional Care
Authors: Duncan Pamela W. , Bushnell Cheryl D. , Jones Sara B. , Psioda Matthew A. , Gesell Sabina B. , D'Agostino Ralph B. , Sissine Mysha E. , Coleman Sylvia W. , Johnson Anna M. , Barton-Percival Blair F. , Prvu-Bettger Janet , Calhoun Adrienne G. , Cummings Doyle M. , Freburger Janet K. , Halladay Jacqueline R. , Kucharska-Newton Anna M. , Lundy-Lamm Gladys , Lutz Barbara J. , Mettam Laurie H. , Pastva Amy M. , Xenakis James G. , Ambrosius Walter T. , Radman Meghan D. , Vetter Betsy , Rosamond Wayne D. ,   on behalf of the COMPASS Site Investigators and Teams.
Published: June 2020

Background
The objectives of this study were to develop and test in real-world clinical practice the effectiveness of a comprehensive postacute stroke transitional care (TC) management program.

Methods and Results
The COMPASS study (Comprehensive Post-Acute Stroke Services) was a pragmatic cluster-randomized trial where the hospital was the unit of randomization. The intervention (COMPASS-TC) was initiated at 20 hospitals, and 20 hospitals provided their usual care. Hospital staff enrolled 6024 adult stroke and transient ischemic attack patients discharged home between 2016 and 2018. COMPASS-TC was patient-centered and assessed social and functional determinates of health to inform individualized care plans. Ninety-day outcomes were evaluated by blinded telephone interviewers. The primary outcome was functional status (Stroke Impact Scale-16); secondary outcomes were mortality, disability, medication adherence, depression, cognition, self-rated health, fatigue, care satisfaction, home blood pressure monitoring, and falls. The primary analysis was intention to treat. Of intervention hospitals, 58% had uninterrupted intervention delivery. Thirty-five percent of patients at intervention hospitals attended a COMPASS clinic visit. The primary outcome was measured for 59% of patients and was not significantly influenced by the intervention. Mean Stroke Impact Scale-16 (±SD) was 80.6±21.1 in TC versus 79.9±21.4 in usual care. Home blood pressure monitoring was self-reported by 72% of intervention patients versus 64% of usual care patients (adjusted odds ratio, 1.43 [95% CI, 1.21–1.70]). No other secondary outcomes differed.

Conclusions
Although designed according to the best available evidence with input from various stakeholders and consistent with Centers for Medicare and Medicaid Services TC policies, the COMPASS model of TC was not consistently incorporated into real-world health care. We found no significant effect of the intervention on functional status at 90 days post-discharge.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT02588664.
Procedural Volume and Outcomes After Primary Percutaneous Coronary Intervention for ST‐Segment–Elevation Myocardial Infarction in Kerala, India: Report of the Cardiological Society of India–Kerala Primary Percutaneous Coronary Intervention Registry
Authors: Jabir Abdullakutty , Mathew Anoop , Zheng Yinggan , Westerhout Cynthia , Viswanathan Sunitha , Sebastian Placid , Kumar Prasanna , Bangalore Sripal , Bainey Kevin R. , Welsh Robert 
Published: June 2020

Background

There are limited data to inform policy mandating primary percutaneous coronary intervention (
PPCI
) volume benchmarks for catheterization laboratories in low‐ and middle‐income countries.

Methods and Results

This prospective state‐wide registry included ST‐segment–elevation myocardial infarction patients with symptoms of <12 hours, or with ongoing ischemia at 12 to 24 hours, reperfused with
PPCI
. From June 2013 to March 2016, we recruited 5560 consecutive patients. We categorized hospitals on the basis of annual
PPCI
volumes into low, medium, and high volume (<100, 100–199, and ≥200 PPCIs per year, respectively). Kaplan‐Meier curves and Cox regression models were used to examine the association between
PPCI
volume and 1‐year mortality. Among 42 recruiting hospitals, there were 24 (57.2%) low‐volume, 8 (19%) medium‐volume, and 10 (23.8%) high‐volume hospitals. The median (25th–75th percentile) TIMI (Thrombolysis in Myocardial Infarction) ST‐segment–elevation myocardial infarction risk score was 3 (2–5). Cardiac arrest before admission occurred in 4.2%, 2.1%, and 2.9% of cases at low‐, medium‐, and high‐volume hospitals, respectively (
P
=0.02). Total ischemic time differed significantly among low‐volume (median [25th–75th percentile], 3.5 [2.4–5.5] hours), medium‐volume (median, 3.8 [25th–75th percentile, 2.58–6.05] hours), and high‐volume hospitals (median, 4.16 [25th–75th percentile 2.8–6.3] hours) (
P
=0.01). Vascular access was radial in 61.5%, 71.3%, and 63.2% of cases at low‐, medium‐, and high‐volume hospitals, respectively (
P
=0.01). The observed 1‐year mortality rate was 6.5%, 3.4%, and 8.6% at low‐, medium‐ and high‐volume hospitals, respectively (
P
<0.01), and the difference did not attenuate after multivariate adjustment (low versus medium: hazard ratio [95%
CI
], 1.80 [1.12–2.90]; high versus medium: hazard ratio [95%
CI
], 2.53 [1.78–3.58]) (
P
<0.01).

Conclusions

Low‐ and middle‐income countries, like India, may have a nonlinear relationship between institutional
PPCI
volume and outcomes, partly driven by procedural variations and inequalities in access to care.
Long‐Term Association of Venous Thromboembolism With Frailty, Physical Functioning, and Quality of Life: The Atherosclerosis Risk in Communities Study
Authors: Lutsey Pamela L. , Windham B. Gwen , Misialek Jeffrey R. , Cushman Mary , Kucharska‐Newton Anna , Basu Saonli , Folsom Aaron R. 
Published: June 2020

Background
Relatively little is known about the long‐term consequences of venous thromboembolism (VTE) on physical functioning. We compared long‐term frailty status, physical function, and quality of life among survivors of VTE with survivors of coronary heart disease (CHD) and stroke, and with those without these diseases.

Methods and Results
Cases of VTE, CHD, and stroke were continuously identified since ARIC (Atherosclerosis Risk in Communities Study) recruitment during 1987 to 1989. Functional measures were objectively captured at ARIC clinic visits 5 (2011–2013) and 6 (2016–2017); quality of life was self‐reported. The 6161 participants at visit 5 were, on average, 75.7 (range, 66–90) years of age. By visit 5, 3.2% had had a VTE, 6.9% CHD, and 3.4% stroke. Compared with those without any of these conditions, VTE survivors were more likely to be frail (odds ratio [OR], 3.11; 95% CI, 1.80–5.36) and have low (<10) versus good scores on the Short Physical Performance Battery (OR, 3.59; 95% CI, 2.36–5.47). They also had slower gait speed, less endurance, and lower physical quality of life. VTE survivors were similar to coronary heart disease and stroke survivors on categorical frailty and outcomes on Short Physical Performance Battery assessment. When score on the Short Physical Performance Battery instrument was modeled continuously, VTE survivors performed better than stroke survivors but worse than CHD survivors.

Conclusions
VTE survivors had triple the odds of frailty and poorer physical function than those without the vascular diseases considered. Their function was somewhat worse than that of CHD survivors, but better than stroke survivors. These findings suggest that VTE patients may benefit from additional efforts to improve postevent physical functioning.
Horizontal Moisture Transport Dominates the Regional Moistening Patterns in the Arctic
Authors: Nygård Tiina , Naakka Tuomas , Vihma Timo 
Published: June 2020

AbstractAlong with the amplified warming and dramatic sea ice decline, the Arctic has experienced regionally and seasonally variable moistening of the atmosphere. Based on reanalysis data, this study demonstrates that the regional moistening patterns during the last four decades, 1979–2018, were predominantly shaped by the strong trends in horizontal moisture transport. Our results suggest that the trends in moisture transport were largely driven by changes in atmospheric circulation. Trends in evaporation in the Arctic had a smaller role in shaping the moistening patterns. Both horizontal moisture transport and local evaporation have been affected by the diminishing sea ice cover during the cold seasons from autumn to spring. Increases in evaporation have been restricted to the vicinity of the sea ice margin over a limited period during the local sea ice decline. For the first time we demonstrate that, after the sea ice has disappeared from a region, evaporation over the open sea has had negative trends due to the effect of horizontal moisture transport to suppress evaporation. Near the sea ice margin, the trends in moisture transport and evaporation and the cloud response to those have been circulation dependent. The future moisture and cloud distributions in the Arctic are expected to respond to changes in atmospheric pressure patterns; circulation and moisture transport will also control where and when efficient surface evaporation can occur.