bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dyslipidemia and Hyperglycemia in Psoriatic Inpatients
Authors: Popchanovski Bojan , Balabanova-Stefanova Margareta 
Published: December 2019

Background: Psoriasis is a chronic cutaneous T-cell mediated disease, which has been associated with many comorbidities, especially with metabolic disorders such as dyslipidemia, diabetes mellitus, obesity, and metabolic syndrome, many of which are themselves risk factors for other diseases. The goal of this study was to evaluate the presence of dyslipidemia and hyperglycemia in patients with psoriasis.
Methods: We compared 48 inpatients with plaque psoriasis aged 29-79, hospitalized between March 2018 and February 2019, to 48 age- and gender-matched controls. We evaluated dyslipidemia and hyperglycemia using enzymatic methods as part of a standard blood test, or medication history indicative of ongoing treatment of dyslipidemia and/or hyperglycemia. Hypertension was evaluated by registering blood pressure greater than 140/90 mmHg or ongoing antihypertensive treatment. Smoking habits were also noted.
Results: There were statistically significant differences between psoriasis patients and controls for elevated total cholesterol (p=0,028), elevated LDL (p=0,015), hypertriglyceridemia (p=0,006), and hyperglycemia (p=0,021). The two groups had statistically insignificant differences for lowered HDL (p=0,084), hypertension (p=1), and smoking (p=0,836).
Conclusion: Hypertriglyceridemia, hyperglycemia, and elevated LDL cholesterol were more prevalent in the group containing psoriatic patients compared to the control group. This indicates that further investigation of metabolic abnormalities should be conducted in psoriatic patients which could greatly benefit from early treatment of the aforementioned underlying conditions.
Rousseau e as instituições ociosas
Authors: Costa Israel Alexandria 
Published: December 2019

O presente artigo situa a ociosidade como tema de filosofia política junto à análise da noção de instituições ociosas, a partir das Considerações sobre o Governo da Polônia, de Jean-Jacques Rousseau. Nesse contexto, em que a ociosidade aparece numa reflexão acerca da natureza da constituição política, o foco da questão é um problema inerente à atividade legislativa: "como incutir a lei nos corações dos cidadãos?". Na abordagem desse problema, destaca-se a reflexão acerca do problema do mal da elusão da lei e, em especial, da proposta de remédio, que avança em relação à superficialidade e à cegueira da visão na qual o tempo do ócio se afigura apenas como intervalo inútil. Na perspectiva rousseauniana aqui desenvolvida, a questão do ócio prende-se à da manipulação dos sentimentos de sociabilidade civil por meio de cerimoniais ociosos que o legislador deve considerar em face do extraordinário poder das instituições ociosas como recursos de fortalecimento da lei.
Política e polícia literárias em Rousseau
Authors: Gomes Lívia Cristina 
Published: December 2019

Este artigo analisa a questão da enunciação literária em alguns dos escritos teóricos de Rousseau, em particular a Carta a D’Alembert (1758), Do contrato social (1762) e o Ensaio sobre a origem das línguas (1781), além do prefácio da Nova Heloísa (1761). Neles, atenta-se ao modo como a literatura está intimamente relacionada à problemática da voz e do ordenamento das enunciações e dos corpos no pensamento político do autor, configurando assim uma política / polícia da literatura, conforme a distinção feita por Jacques Rancière (1996).
Reseña: "Literatura y globalización. Latinoamérica en el nuevo milenio" (2019), de Eva Valero Juan y Oswaldo Estrada (eds.)
Authors: Arias Negredo Judith 
Published: December 2019

Reseña: "Literatura y globalización. Latinoamérica en el nuevo milenio" (2019), de Eva Valero Juan y Oswaldo Estrada (eds.)
Comparison of Commercial Gluten Containing and Gluten Free Pastas: Cooking Quality Parameters
Authors: Gokhisar Ozge Kurt , Turhan Mahir 
Published: December 2019

Aims: Gluten-free food (GFF) consumers reportedly have problems with the lower cooking quality of gluten-free pastas (GFPs) compared to gluten-containing pastas (GCPs). This work is designed to compare the cooking quality of commercial GFPs and GCPs population wise for contributing to the resolution of the issue in the market.
Study Design, Materials and Methodology: Cooking quality parameters of 10 commercial GFPs (maize based and maize-rice based) and 10 commercial GCPs (semolina), namely optimum cooking time (OCT), weight increase (WI), volume increase (VI), cooking loss (CL), and their microstructures were determined.
Results: GCPs had shorter OCT, higher WI and VI, and lower CL than GFPs (P < .05), representing higher cooking quality. GCPs showed more consistent cooking quality compared to GFPs. GCPs showed more consistent cooking quality compared to GFPs. GFPs made of maize showed higher cooking quality than GFPs made of maize and rice mixture (P < .05). When considering the microstructure, GCPs has a smooth outer surface where the gluten network provides a framework that holds embedded starch granules. On the other hand, GFPs has a protruding surface where gelatinized starch provides a framework that holds embedded protein patches, which results poor cooking quality.
Conclusion: GCPs shows higher cooking quality compared to GFPs. They also exhibited a narrower range for cooking quality parameters indicating their more consistent behavior than those of GFPs. GFPs made of maize showed higher cooking quality than GFPs made of maize and rice mixture.
Originality/value: To the best of the authors’ knowledge, this is the first work comparing the cooking quality of populations of commercial pastas (10 GFPs versus 10 GCPs) and embodied the issue.
Demographic and spatial responses of resident bird populations to the arrival of migratory birds within an urban environment
Authors: Ramírez‐Cruz Gonzalo A. , Solano‐Zavaleta Israel , Méndez‐Janovitz Marcela , Zúñiga‐Vega J. Jaime 
Published: December 2019

AbstractLong‐distance migration allows many bird species to overcome the severe climatic changes that occur in seasonal environments. Migration is highly demanding, and given its cyclical nature, we currently know that it has substantial effects on the population parameters of migratory birds during both breeding and wintering seasons. However, the potential effects of the presence of migratory birds in their wintering grounds on populations of resident birds have remain largely unexplored. Here, we propose the hypothesis that migratory birds negatively affect the habitat occupancy and population abundance of resident birds because of the arrival of numerous individuals during the most limiting months of the year. Here, we studied different species of migratory and resident birds that coexist during winter in an urban ecological reserve located within Mexico City. We used single‐species multiseason occupancy models, two‐species occupancy models, and distance sampling techniques to evaluate changes in occupancy and population density of resident bird species during three consecutive winters. We found an aggregation pattern between two resident species (Psaltriparus minimusandThryomanes bewickii) with three migratory warblers (Cardellina pusilla,Setophaga coronataandSetophaga townsendi). Thus, our results provide evidence of the formation of mixed‐species flocks in our study area. We also conclude that resident birds experience different demographic and behavioral processes during winter that not necessarily result from interspecific interactions with migratory birds.
Designing Microgels for Cell Culture and Controlled Assembly of Tissue Microenvironments
Authors: Caldwell Alexander S. , Aguado Brian A. , Anseth Kristi S. 
Published: December 2019

AbstractMicrometer‐sized hydrogels, termed microgels, are emerging as multifunctional platforms that can recapitulate tissue heterogeneity in engineered cell microenvironments. The microgels can function as either individual cell culture units or can be assembled into larger scaffolds. In this manner, individual microgels can be customized for single or multicell coculture applications, or heterogeneous populations can be used as building blocks to create microporous assembled scaffolds that more closely mimic tissue heterogeneities. The inherent versatility of these materials allows user‐defined control of the microenvironments, from the order of singly encapsulated cells to entire 3D cell scaffolds. These hydrogel scaffolds are promising for moving towards personalized medicine approaches and recapitulating the multifaceted microenvironments that exist in vivo.
Engineering a Novel 3D Printed Vascularized Tissue Model for Investigating Breast Cancer Metastasis to Bone
Authors: Cui Haitao , Esworthy Timothy , Zhou Xuan , Hann Sung Yun , Glazer Robert I. , Li Rong , Zhang Lijie Grace 
Published: December 2019

AbstractCancer metastases are a challenge for cancer treatment due to their organ specificity and pathophysiological complexity. Engineering 3D in vitro models capable of replicating native cancer dissemination can significantly improve the understanding of cancer biology and can help to guide the development of more effective treatments. In order to better mimic the behavior of native cancer, a triculture metastatic model is created using a stereolithography printing technique with optimized inks for investigating the invasion of breast cancer (BrCa) cells into vascularized bone tissue. The printed system allows to study transendothelial migration and the colony‐forming behavior of metastatic BrCa cells. The key steps of BrCa cell progression including expansion, migration, and colonization are continuously monitored and the interactions between cancer cells, vascular cells, and bone cells are systematically investigated. The study results demonstrate that the 3D printed tissue construct by incorporating multiple cells and various favorable ink matrices provides a suitable model to study the interaction between these cells in a complex vascular microenvironment. As such, the 3D printed tricultured model may serve as a valuable tool for studying metastatic breast cancer progression in bone.
Highly Sensitive and Flexible Pressure Sensor Prepared by Simple Printing Used for Micro Motion Detection
Authors: Ma Zhihua , Wang Wei , Yu Dan 
Published: December 2019

AbstractSmart wearable flexible sensors with high sensitivity and stability are still challenging nowadays when used for human motion detection, personal health monitoring, or artificial electronic skins. Here, a sensor assembled in a face‐to‐face manner based on fabric is proposed, firstly polyaniline (PANI)/nanonickel (Ni NPs)/COOH‐functionalized MWCNTs (COOH‐MWCNTs) conductive paste is prepared and printed on the cotton fabric. Then the printed fabric is assembled to be a flexible sensor which has double conductive layers. According to the analysis of the scanning electron microscopy, energy‐dispersive spectroscopy, X‐ray diffraction, and Fourier transform infrared spectroscopy, the synergistic performance of PANI, Ni NPs, and COOH‐MWCNTs is demonstrated. When the pressure is 0–0.1 kPa, gauge factor (GF) is 12.96 kPa−1, and when the pressure is 0.1–1 kPa, the GF is 1.33 kPa−1, indicating superior sensitivity of the sensor compared to traditional textile‐based sensors. It also displays quick response time of 0.2 s and recovery time of 0.3 s. The as‐prepared sensor can effectively monitor human micro motions like face, eye, and fingers movements, and it can also transmit electrical signals agilely by indirect contact. Moreover, a large‐area sensor spatial array is fabricated, and the test indicates the sensor can recognize spatial response.
Macrophage‐Mediated Delivery of Hypoxia‐Activated Prodrug Nanoparticles
Authors: Evans Michael A. , Shields C. Wyatt , Krishnan Vinu , Wang Lily Li‐Wen , Zhao Zhongmin , Ukidve Anvay , Lewandowski Michael , Gao Yongsheng , Mitragotri Samir 
Published: December 2019

AbstractHypoxia‐activated prodrugs (HAPs) have tremendous clinical potential due to their selective toxicity toward poorly oxygenated tissues, which is a hallmark of solid tumors. Despite their promising results in vitro, HAPs have failed to make a clinical impact. This is largely because tumor hypoxia is located far from blood vessels, making it difficult for HAPs to accumulate in therapeutically sufficient concentrations. Here, a generalized strategy to overcome this barrier by employing macrophages as drug carriers to enhance the penetration and accumulation of HAPs deep in solid tumors is reported. The system leverages the chemotactic and phagocytic abilities of macrophages to improve delivery of nanoparticles encapsulating a model HAP, tirapazamine (TPZ), to the hypoxic regions of solid tumors. A sequence of in vitro assays is used to refine the properties of the system by minimizing carrier cell toxicity while maximizing therapeutic efficacy. It is demonstrated in vivo that the system improves drug accumulation in hypoxic areas of 4T1 breast tumors and slows their growth by itself and in combination with irinotecan. The results provide early evidence that macrophages can significantly improve the transport and efficacy of HAPs by improving their tumor penetration, highlighting a potential strategy to advance them into the clinic.
Electrochemical β‐Selective Hydrocarboxylation of Styrene Using CO2 and Water
Authors: Kim Younghye , Park Gyeong Do , Balamurugan Mani , Seo Jiwon , Min Byoung Koun , Nam Ki Tae 
Published: December 2019

AbstractThe carboxylation of hydrocarbons using CO2 as a one‐carbon building block is an attractive route for the synthesis of carboxylic acids and their derivatives. Until now, chemical carboxylation catalyzed by organometallic nucleophiles and reductants has been generally adopted particularly for the precise selectivity control of carboxylation sites. As another approach, electrochemical carboxylation has been attempted but these carboxylation reactions are limited to only a few pathways. In the case of styrene, dicarboxylation at the α‐ and β‐positions is mostly observed with electrochemical carboxylation while site‐selective hydrocarboxylations are hardly achieved. In this study, electrochemical β‐selective hydrocarboxylation of styrene using CO2 and water is developed, in which the site selectivity can be precisely controlled between β‐hydrocarboxylation and dicarboxylation without the aid of homogeneous catalysts. In this platform, water is used as proton source in the β‐hydrocarboxylation of styrene where its addition results in significant enhancement of the selectivity toward β‐hydrocarboxylation. This work provides insights into new strategies for site‐selectivity‐controllable carboxylation with CO2 using an electrochemical platform.
SnO2 as Advanced Anode of Alkali‐Ion Batteries: Inhibiting Sn Coarsening by Crafting Robust Physical Barriers, Void Boundaries, and Heterophase Interfaces for Superior Electrochemical Reaction Reversibility
Authors: Zhao Shiqiang , Sewell Christopher D. , Liu Ruiping , Jia Songru , Wang Zewei , He Yanjie , Yuan Kunjie , Jin Huile , Wang Shun , Liu Xueqin , Lin Zhiqun 
Published: December 2019

AbstractSuperior reaction reversibility of electrode materials is urgently pursued for improving the energy density and lifespan of batteries. Tin dioxide (SnO2) is a promising anode material for alkali‐ion batteries, having a high theoretical lithium storage capacity of 1494 mAh g− based on the reactions of SnO2 + 4Li+ + 4e− ↔ Sn + 2Li2O and Sn + 4.4Li+ + 4.4e− ↔ Li4.4Sn. The coarsening of Sn nanoparticles into large particles induced reaction reversibility degradation has been demonstrated as the essential failure mechanism of SnO2 electrodes. Here, three key strategies for inhibiting Sn coarsening to enhance the reaction reversibility of SnO2 are presented. First, encapsulating SnO2 nanoparticles in physical barriers of carbonaceous materials, conductive polymers or inorganic materials can robustly prevent Sn coarsening among the wrapped SnO2 nanoparticles. Second, constructing hierarchical, porous or hollow structured SnO2 particles with stable void boundaries can hinder Sn coarsening between the void‐divided SnO2 subunits. Third, fabricating SnO2‐based heterogeneous composites consisting of metals, metal oxides or metal sulfides can introduce abundant heterophase interfaces in cycled electrodes that impede Sn coarsening among the isolated SnO2 crystalline domains. Finally, a perspective on the future prospect of the structural/compositional designs of SnO2 as anode of alkali‐ion batteries is highlighted.
Fluidization of spherical versus elongated particles: Experimental investigation using magnetic particle tracking
Authors: Mema Ivan , Buist Kay A. , Kuipers J.A.M. (Hans) , Padding Johan T. 
Published: December 2019

AbstractIn biomass processing fluidized beds are used to process granular materials where particles typically possess elongated shapes. However, for simplicity, in computer simulations particles are often considered spherical, even though elongated particles experience more complex particle–particle interactions as well as different hydrodynamic forces. The exact effect of these more complex interactions in dense fluidized suspensions is still not well understood. In this study we use the magnetic particle tracking technique to compare the fluidization behavior of spherical particles to that of elongated particles. We found a considerable difference between fluidization behavior of spherical versus elongated particles in the time‐averaged particle velocity field as well as in the time‐averaged particle rotational velocity profile. Moreover, we studied the effect of fluid velocity and the particle's aspect ratio on the particle's preferred orientation in different parts of the bed, which provides new insight in the fluidization behavior of elongated particles.
Mechanical properties and thermal stability of porous polyimide/hollow mesoporous silica nanoparticles composite films prepared by using polystyrene microspheres as the pore‐forming template
Authors: Jia Weihong , Wang Jinqing , Ma Limin , Ren Sili , Yang Shengrong 
Published: December 2019

ABSTRACTThe porous polyimide/hollow mesoporous silica nanoparticles (PI/HMSNs) composite films were fabricated via blending polymerization by using polystyrene (PS) microspheres as the pore‐forming template. The morphologies, microstructures, thermal stability, thermal expansion coefficient (TEC), and mechanical performances of the porous PI/HMSNs films were characterized in detail. Results showed that the uniform dispersion of HMSNs benefits from the strong hydrogen‐bonding interaction between the hydroxyl groups of HMSNs and poly(amic acid) chains. Both weight loss and TEC of the porous PI/HMSNs films are lower than those of the pure porous PI film. When 0.8 wt % HMSNs and 7.0 wt % PS were added into the PI matrix, the Young's modulus and tensile strength of composite film increased by about 32.4% and 68.1% compared with those of the pure porous PI film. Conclusively, the introduction of HMSNs in the porous PI matrix is an important strategy to enrich the diversity of porous structure, improve the thermal and mechanical properties of the porous PI material simultaneously. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2020,137, 48792.
From zero crossings to quantile‐frequency analysis of time series with an application to nondestructive evaluation
Authors: Li Ta‐Hsin 
Published: December 2019

AbstractRepresented by the pioneering works of Professor Benjamin Kedem, zero crossings of time‐series data have been proven useful for characterizing oscillatory patterns in many applications such as speech recognition and brainwave analysis. Robustness against outliers and nonlinear distortions is one of the advantages of zero crossings in comparison with traditional spectral analysis techniques. This paper introduces a new tool of spectral analysis for time‐series data that goes beyond zero crossings. It is called quantile‐frequency analysis (QFA). Constructed from trigonometric quantile regression, QFA transforms a time series into a bivariate function of quantile level and frequency variable. For each fixed quantile level, it corresponds to a periodogram‐like function, called the quantile periodogram, which characterizes the oscillatory behavior of the time series round the quantile. By coupling QFA with functional principal component analysis, new dimension‐reduced features are proposed for discriminant analysis of time series. The usefulness of these features is demonstrated by a case study of classifying real‐world ultrasound signals for nondestructive evaluation of aircraft panels. Various machine learning classifiers are trained and tested by cross‐validation. The results show a clear advantage of the QFA method over its ordinary‐periodogram–based counterpart in delivering higher out‐of‐sample classification accuracy.
Magnetized Bose–Einstein condensate stars with boundary conditions depending on magnetic field
Authors: Quintero Angulo Gretel , Pérez Martínez Aurora , Pérez Rojas Hugo 
Published: December 2019

AbstractIn this article, we analyze the impact of the magnetic field‐dependent boundary conditions on the solutions of the γ‐structure equations for magnetized Bose–Einstein condensate stars (BECs). We consider two cases: pure BECs and BECs surrounded by a magnetic field. As they correspond to different physical situations, they lead to different numerical behaviors, having important effects on the stability of the solutions, as well as on the observables of the star. The differences between the mass–radii curves obtained in each situation are presented and discussed.
A rapid assay to screen adenosine deaminase inhibitors from Ligustri Lucidi Fructus against metabolism of cordycepin utilizing ultra‐high‐performance liquid chromatography–tandem mass spectrometry
Authors: Guan Huida , Qi Shenglan , Liu Wei , Ma Chao , Wang Changhong 
Published: December 2019

AbstractCordycepin has recently received increased attention owing to its extensive pharmacological activity. Adenosine deaminase (ADA) is widely distributed in mammalian blood and tissues; as a result, cordycepin is quickly metabolized upon entering into the body and converted into the inactive metabolite 3′‐deoxyinosine, thus limiting its activity when administered alone. We herein present a novel ultra‐high‐performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) method for screening ADA inhibitors against the metabolism of cordycepin. Cordycepin and 3′‐deoxyinosine were chosen as substrate and product, respectively. A proper separation was achieved for all analytes within 3 min. 3′‐Deoxyinosine was quantified in the presence or absence of potential ADA inhibitors to evaluate ADA activity. The assay can simultaneously determine substrate and product, with the endogenous substance and ADA inhibitors added not interfering in its activity. After optimizing the enzymatic incubation and UHPLC–MS/MS conditions, Km and Vmax values for ADA deamination of cordycepin were 95.18 ± 7.85 μm and 363.90 ± 12.16 μmol/min/unit, respectively. Oleanolic acid and ursolic acid from Ligustri Lucidi Fructus were chosen as ADA inhibitors with half maximal inhibitory concentration values of 21.82 ± 0.39 and 18.41 ± 0.14 μm, respectively. A non‐competitive inhibition model was constructed and this assay can be used to screen other potential ADA inhibitors quickly and accurately.