bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generational differences in risk perception and situational uses of wine information sources
Authors: Bauman Matthew J. , Velikova Natalia , Dodd Tim , Blankenship Trey 
Published: December 2019

Purpose
The purpose of this study is to examine generational differences in consumer Web 2.0 information source adoption for wine purchasing decisions, particularly social media and internet-based sources.

Design/methodology/approach
An online survey resulted in 276 responses from wine consumers residing in Texas, USA. Information source usage was tested in two common purchasing situations: for casual and formal consumption. Chi-square analyses and ANOVA were used to examine differences among the generational cohorts in their use of information sources, levels of objective and subjective wine knowledge, wine involvement and risk perception for the two purchasing situations.

Findings
Younger consumers were found to be significantly more inclined to use Web 2.0 information sources, such as wine blogs, wine applications, their contacts’ recommendations on social media and wine experts on social media. Older consumers were more likely to use their own wine knowledge. Of greater interest is that in terms of their reliance on various wine information sources, Generation X behaves as the bridge between Generation Y and Baby Boomers. Generational differences regarding wine involvement, wine knowledge and risk perception also support this notion.

Practical implications
The results of this study reinforce the need for wineries to adopt or create strategic initiatives using Web 2.0 elements. This study also suggests that depending on the purchasing context, consumers use certain information sources more than others.

Originality/value
This research extends the understanding of the information acquisition process by expanding the types of information sources, and also yields valuable insights for consumers’ off-premise wine purchasing decisions.
Axial strength of modified fibrous foamed concrete-filled hollow section
Authors: Abd Rahman Norashidah , Khairuddin Siti Amirah Azra , Faudzi Mohd Faris , Mohd Asri Mohd Harith Imran , Jamaluddin Norwati , Mohd Jaini Zainorizuan 
Published: December 2019

Purpose
Concrete-filled hollow section (CFHS) is widely used in steel construction. The combination of concrete and steel decreases buckling and deformation of steel. However, studies reveal that using normal concrete increases the dead weight of a structure. Therefore, a lightweight concrete, such as foamed concrete (FC), is proposed to reduce the weight of the structure. The purpose of this study is to determine the strength of modified fibrous foamed CFHS (FCFHS).

Design/methodology/approach
Steel and polypropylene fibres were used with rice husk ash, and short column fibrous FCFHSs were tested under compression load. Greased and non-greased methods were adopted to determine bond strength and confining effect between steel and concrete.

Findings
Results indicate that the use of fibre in FCFHSs improves the strength of CFHS from 9% to 11%. The non-greased method confirms that an interaction exists between steel and concrete with a confinement coefficient of more than 2.0.

Originality/value
It can be shown that the modified fibrous foamed concrete can increase the strength of the concrete and can be used as concrete filled in steel construction industry.
Elastic full waveform inversion with probabilistic petrophysical clustering
Authors: Aragao Odette , Sava Paul 
Published: December 2019

ABSTRACTFull waveform inversion aims to use all information provided by seismic data to deliver high‐resolution models of subsurface parameters. However, multiparameter full waveform inversion suffers from an inherent trade‐off between parameters and from ill‐posedness due to the highly non‐linear nature of full waveform inversion. Also, the models recovered using elastic full waveform inversion are subject to local minima if the initial models are far from the optimal solution. In addition, an objective function purely based on the misfit between recorded and modelled data may honour the seismic data, but disregard the geological context. Hence, the inverted models may be geologically inconsistent, and not represent feasible lithological units. We propose that all the aforementioned difficulties can be alleviated by explicitly incorporating petrophysical information into the inversion through a penalty function based on multiple probability density functions, where each probability density function represents a different lithology with distinct properties. We treat lithological units as clusters and use unsupervised K‐means clustering to separate the petrophysical information into different units of distinct lithologies that are not easily distinguishable. Through several synthetic examples, we demonstrate that the proposed framework leads full waveform inversion to elastic models that are superior to models obtained either without incorporating petrophysical information, or with a probabilistic penalty function based on a single probability density function.
Knockdown of GCN2 inhibits high glucose‐induced oxidative stress and apoptosis in retinal pigment epithelial cells
Authors: Zhang Xiaohui , He Na , Xing Yao , Lu Ye 
Published: December 2019

AbstractIncreasing evidence suggests that general control nonderepressible 2 (GCN2) is a critical regulator of oxidative stress and cell apoptosis in response to various stimuli. However, the role of GCN2 in diabetic retinopathy remains unclear. The aim of the present study was to investigate the effects of GCN2 on oxidative stress and apoptosis in ARPE‐19 cells exposed to high glucose. The results showed that GCN2 was highly expressed in high glucose‐induced ARPE‐19 cells. Moreover, knockdown of GCN2 greatly improved ARPE‐19 cell viability in response to high glucose. In addition, GCN2 knockdown significantly suppressed the production of reactive oxygen species (ROS) and malondialdehyde (MDA), as well as increased superoxide dismutase (SOD) activity in high glucose‐stimulated ARPE‐19 cells. Furthermore, GCN2 knockdown reduced cell apoptosis and enhanced the activation of nuclear factor E2‐related factor 2/heme oxygenase‐1 (Nrf2/HO‐1) pathway in high glucose‐stimulated ARPE‐19 cells. However, knockdown of Nrf2 reversed the effects of GCN2 on oxidative stress and cell apoptosis. Taken together, our findings suggest that knockdown of GCN2 inhibits high glucose‐induced oxidative stress and apoptosis in ARPE‐19 cells through activation of the Nrf2/HO‐1 pathway.
Three‐year surveillance (2016–2018) of chigger mites vector for tsutsugamushi disease in the Hwaseong‐Si area of Gyeonggi‐Do, Republic of Korea
Authors: Jun Hojong , Jegal Seung , Kim‐Jeon Myung‐Deok , Roh Jong Yul , Lee Wook‐Gyo , Park Seo Hye , Ahn Seong Kyu , Lee Jinyoung , Gong Young Woo , Kwon Mun Ju , Bahk Young Yil , Kim Tong‐Soo 
Published: December 2019

AbstractOwing to climate change, the global resurgence of vector‐borne infectious diseases has emerged as a critical public health issue. Orientia tsutsugamushi is the etiological agent of tsutsugamushi disease (scrub typhus) a mite‐borne acute febrile disease occurring in the Asia‐Pacific region. We investigated the prevalence of tsutsugamushi disease transmitted by chigger mite vectors living on rodents. Using sticky‐type chigger traps for three months during 2016–2018, 1,057 chigger mites were collected (chigger mite index, 1.31) from four locations in the Hwaseong‐si area of Gyeonggi‐do, Republic of Korea. Five species distributed among three genera were identified. In addition, 94 rodents were captured (collection rate: 7.83%) using Sherman live traps over the course of three months (April, October, and November) during 2016–2017. Three rodent species were captured and identified and the striped field mouse (Apodemus agrarius) was the dominant rodent host species in the surveyed area. A total of 10,469 ectoparasitic chigger mites were recovered from the 94 rodents, from which 13 species distributed among four genera were identified. Of the 5,250 chigger mites examined, Leptotrombidium pallidum was most abundant (n = 2,558), followed by L. orientale, L. scutellare, L. zetum, Euschoengastia koreaensis, L. subintermedium, and Neotrombicula tamiyai. Of the examined chigger mites, no groups recovered from rodent hosts tested positive for O. tsutsugamushi. This study provides fundamental regional information on vector‐borne disease data collection in the Hwaseong‐si area, Gyeonggi‐do, and will further contribute to formulating disease control and prevention strategies.
The effects of feed materials on the nutrient composition of Protaetia brevitarsis larvae
Authors: Jeong Deokyeol , Min Namgyong , Kim Yeongbu , Kim Soo Rin , Kwon Ohseok 
Published: December 2019

AbstractTo find out the effect of feed materials on the nutrient composition of Protaetia brevitarsis larvae (Pbl), three different feed materials were prepared and fed to the Pbl populations. After the Pbl population reached the third instar stage, they were boiled and dried for the nutrient analysis. The results showed that the nutrient composition of Pbl varied in response to the feed materials. Therefore, it is critical to set a feed material standard to guarantee the efficacy of Pbl medicinal property.
Cryopyrin‐associated periodic fever syndrome in children: A case‐based review
Authors: Gupta Ayush , Tripathy Saroj Kumar , Phulware Ravi Hari , Arava Sudheer , Bagri Narendra Kumar 
Published: December 2019

AbstractCryopyrin‐associated periodic fever syndrome (CAPS) represents an increasingly recognized disease group entity, with varied presentations. CAPS includes 3 clinical entities, namely, familial cold‐induced autoinflammatory syndrome (FCAS; MIM #120100), Muckle‐Wells syndrome (MWS; MIM #191900) and chronic inflammatory neurologic cutaneous and articular syndrome (CINCA; MIM #607115); which share several overlapping clinical features. These patients often present with early‐onset episodes of fever and rash, and variable systemic signs and symptoms, making it a great mimicker of other systemic autoimmune diseases. The episodes are transient and related to exposure to cold temperature and worsen in the winter season. We hereby present a case presenting with recurrent seasonal fever and rash, diagnosed as FCAS/ MWS overlap based on clinical signs and symptoms and positive testing for NLRP3 gene mutation. We also discuss the clinical presentation and complications of CAPS, chiefly FCAS and MWS, along with the previously described pediatric cases of CAPS. We tried to review the complexities of management of such patients, including the genetic diagnosis and the role of biological therapy. Based on the review of the literature, given the evident broad spectrum of symptoms and signs, use of next‐generation sequencing can help in prompt diagnosis and early initiation of biological agents, which may play a great role in reducing the complications that these patients may experience in the long run.
The role of rhizodeposits in shaping rhizomicrobiome
Authors: Tian Tao , Reverdy Alicyn , She Qianxuan , Sun Bingbing , Chai Yunrong 
Published: December 2019

SummaryRhizomicrobiome, the communities of microorganisms surrounding the root of the plant, plays a vital role in promoting plant growth and health. The composition of rhizomicrobiome is dynamic both temporally and spatially, and is influenced greatly by the plant host and environmental factors. One of the key influencing factors is rhizodeposits, composed of root‐released tissue cells, exudates, lysates, volatile compounds, etc. Rhizodeposits are rich in carbon and nitrogen elements, and able to select and fuel the growth of rhizomicrobiome. In this minireview, we overview the generation, composition and dynamics of rhizodeposits, and discuss recent work describing the general and specific impacts of rhizodeposits on rhizomicrobiome. We focus further on root exudates, the most dynamic component of rhizodeposits, and review recent progresses about the influence of specific root exudates in promoting bacterial root colonization, inducing biofilm development, acting as plant defence and shaping the rhizomicrobiome.
The Role of AIIB in the ‘New Normal’ Era for Indonesia and ASEAN
Authors: Basri M. Chatib 
Published: December 2019

AbstractHistory shows that trade and industrialization were the keys to economic development in East Asia and Southeast Asia. But situations change. The current rise in economic nationalism leads one to ask: Can Southeast Asian nations, including Indonesia, still use the old recipe of open trade and industrialization? Does economic cooperation still have a place? Against the backdrop of a changing trade environment and creeping protectionism under the Donald Trump US administration and amid lackluster global growth, the question that we must ask is, what can Indonesia and other Southeast Asian nations do given these conditions? This essay will specifically examine how the Asian Infrastructure Investment Bank (AIIB) can play a role in this situation. This essay argues that to overcome the anti‐globalization sentiment, it is necessary to create regional cooperation success stories from policies that are politically feasible and economically sound. There are several candidates for such success stories, including using the ASEAN Infrastructure Fund to develop ASEAN connectivity. The AIIB together with the ADB can play an important role here.
Comparative study of three types of lymphadenectomy along the left recurrent laryngeal nerve by minimally invasive esophagectomy
Authors: Zhang Shuangping , Zhang Peng , Guo Shiping , Lian Jianhong , Chen Yun , Chen Ailan , Ma Yong , Li Feng 
Published: December 2019

BackgroundThe objective of this study was to compare three kinds of lymphadenectomy methods along the recurrent laryngeal nerve (RLN) and assess the safety and effectiveness of the new method.MethodsA total of 194 patients with esophageal cancer who underwent minimally invasive esophagectomy (MIE) at our institution from May 2013 to May 2017 were analyzed retrospectively. According to the method of lymphadenectomy along the left RLN, the patients were divided into three groups: 75 cases underwent the conventional method (A group), 80 cases the skeletonized method (B group) and 39 cases the modified Bascule method (C group). The number of dissected lymph nodes and surgical outcomes were recorded and compared to identify differences among the three groups.ResultsThe frequency of metastasis to the LRLN lymph node was 18.6% among all patients, and 12%, 20% and 28% in groups A, B and C, respectively. The number of harvested lymph nodes (total/chest/LRLN/LRLN+) in group B and group C were significantly greater than that of group A, but not significant between group B and group C. The hoarseness rate in group C was 15.4%, which was lower than the rate in group B (21.3%) and higher than the rate in group A (13.3%), but there was no statistical significance.ConclusionsThe new method for lymphadenectomy along the left RLN during MIE in the semi‐prone position is safe and reliable. It provides sufficient lymph node dissection along the left RLN.
Castries Merchandising Inc.
Authors: Kalesnikoff Douglas , Hernik Michael 
Published: December 2019

ABSTRACTThis two‐part case focuses on red flags of attempted earnings management for a St. Lucian company that is moving from 100 percent family‐owned to selling 50 percent of the family's shares to an equity fund. In order to increase the earnings growth rate in the three years leading up to the proposed sale to an equity fund in 2021, the earnings for the most recent three years (2016–2018) have been artificially depressed. The resulting byproduct of the earnings management is the underprovision of income taxes for the past three years, which is detected by the tax authorities in St. Lucia. The student assumes the role of a tax auditor for the tax authority in St. Lucia assigned to audit Castries Merchandising Inc. (CMI), a merchandiser of building products, hardware, and automobile parts. In Part 1 the student is provided excerpts of the financial statements of CMI with some anomalies that have been detected by a software program. In Part 2 the student is provided with further information of excerpts from the trial balance and an interview with the CFO, who is a member of the family ownership group of CMI and also a Canadian CPA registered in Ontario. Drawing on the student's knowledge of auditing, accounting principles, and financial statement analysis, the student's task is to both reassess the income taxes for the years 2016 to 2018 and contemplate how management may be manipulating the financial statements in order to benefit from the planned future sale of CMI's shares to an equity fund.
Carbetocin at elective caesarean section: a sequential allocation trial to determine the minimum effective dose in obese women
Authors: Drew T. , Balki M. , Farine D. , Ye X. Y. , Downey K. , Carvalho J. C. A. 
Published: December 2019

SummaryPostpartum haemorrhage is a leading cause of maternal death during childbirth. There is an increasing incidence of atonic postpartum haemorrhage in developed countries, and maternal obesity has been proposed as a contributing factor. The dose–response relationship of carbetocin in obese women has not yet been determined. We conducted a double‐blind, dose‐finding study of carbetocin using a biased coin up‐and‐down design in women with a body mass index ≥ 40 kg.m−2 undergoing elective caesarean section. The determinant for a successful response was satisfactory uterine tone, with no intra‐operative need for additional uterotonic drugs. Secondary outcomes included the use of additional uterotonic drugs postoperatively, estimated blood loss and adverse effects of carbetocin administration. Thirty women were recruited to the study. The median (IQR [range]) body mass index was 44.93 (41.5–55.2 [40–66.5]) kg.m−2. The ED90 of carbetocin was estimated as 62.9 (95%CI 57.0–68.7) μg using the truncated Dixon and Mood method, and 68 (95%CI 52–77) μg using the isotonic regression method. The estimated blood loss was 880 (621–1178 [75–2442]) ml. The overall rates of hypotension and hypertension after delivery were 40% and 6.7%, respectively, while nausea occurred in 26.7% of women. The ED90 for carbetocin in obese women at elective caesarean section is lower than the dose of 100 μg currently recommended by the Society of Obstetricians and Gynaecologists of Canada, but is approximately four times higher than the previously demonstrated ED90 of 14.8 μg in women with body mass index < 40 kg.m−2.
Estimating treatment importance in multidrug‐resistant tuberculosis using Targeted Learning: An observational individual patient data network meta‐analysis
Authors: Wang Guanbo , Schnitzer Mireille E. , Menzies Dick , Viiklepp Piret , Holtz Timothy H. , Benedetti Andrea 
Published: December 2019

AbstractPersons with multidrug‐resistant tuberculosis (MDR‐TB) have a disease resulting from a strain of tuberculosis (TB) that does not respond to at least isoniazid and rifampicin, the two most effective anti‐TB drugs. MDR‐TB is always treated with multiple antimicrobial agents. Our data consist of individual patient data from 31 international observational studies with varying prescription practices, access to medications, and distributions of antibiotic resistance. In this study, we develop identifiability criteria for the estimation of a global treatment importance metric in the context where not all medications are observed in all studies. With stronger causal assumptions, this treatment importance metric can be interpreted as the effect of adding a medication to the existing treatments. We then use this metric to rank 15 observed antimicrobial agents in terms of their estimated add‐on value. Using the concept of transportability, we propose an implementation of targeted maximum likelihood estimation, a doubly robust and locally efficient plug‐in estimator, to estimate the treatment importance metric. A clustered sandwich estimator is adopted to compute variance estimates and produce confidence intervals. Simulation studies are conducted to assess the performance of our estimator, verify the double robustness property, and assess the appropriateness of the variance estimation approach.
The effect of ventilation tube insertion on quality of life in children with persistent otitis media with effusion
Authors: Sanyaolu Leigh N. , Cannings‐John Rebecca , Butler Christopher C. , Francis Nick A. 
Published: December 2019

AbstractObjectivesTo determine the effect of ventilation tube (VT) surgery on quality of life (QoL) in children with persistent otitis media with effusion (OME).DesignSecondary analysis of trial data (oral steroids versus placebo for persistent OME), comparing QoL by history of VT surgery performed between 5 weeks and 12 months post‐randomisation. Multilevel regression models were used to identify the association between VT surgery and QoL scores at 12 months, controlling for pre‐exposure risk factors associated with surgery, including pre‐surgery hearing level.SettingEar, nose and throat (ENT), paediatric audiology and audiovestibular medicine (AVM) departments in Wales and England.ParticipantsA total of 327 children aged 2‐8 years with OME symptoms for at least three months and audiometry‐proven bilateral hearing loss with VT surgery status.Main outcome measuresOtitis Media questionnaire (OM8‐30) and Paediatric Quality of Life Inventory (PedsQL) total and subscale scores, and the Health Utilities Index Mark 3 (HUI3) at 12 months post‐randomisation.ResultsParticipants who had VT surgery had no significant difference in OM8‐30, PedsQL or HUI total scores. OM8‐30 hearing difficulty (HD) subscale scores at 12 months were better in those who had VT surgery (adjusted mean difference (aMD) = −0.46 (95% confidence interval: −0.69 to −0.23), P < .001), and this varied by when the surgery occurred (aMD for surgery between 5 weeks and 6 months = −0.4 [−0.67 to −0.13], P = .004 and between 6 and 12 months = −0.54, [−0.87 to −0.22], P = .001).ConclusionVentilation tube surgery was associated with an improvement in HD‐related functional health status but no change in overall QoL.
Site‐specific profiles of biochemical properties in the larval digestive tract of Japanese rhinoceros beetle, Trypoxylus dichotomus (Coleoptera: Scarabaeidae)
Authors: Wada Noriko , Iwabuchi Noriyuki , Sunairi Michio , Nakajima Mutsuyasu , Iwata Ryûtarô , Anzai Hirosi 
Published: December 2019

AbstractThe larvae of Japanese rhinoceros beetle, Trypoxylus dichotomus, feed on dead plant material in forest soils that are derived from fallen leaves broken down by basidiomycete fungi. Our previous work provided an understanding of the degradation of polysaccharides in dead plant material by T. dichotomus larvae and reported the complexity of the physicochemical and biochemical environment of the larval gut. Here, we examined ten divisions of the digestive tract of T. dichotomus larvae for physicochemical and biochemical conditions to elucidate site‐specifically functional properties along the tract. The distribution of potassium ions, pH, and acetic acid differed markedly along the length of the digestive tract with the potassium ion concentration profile closely reflecting that of pH along the length of the digestive tract. Distinct physicochemical environments were maintained in the digestive tract along with site‐specific polysaccharide degradation. Based on these findings, we suggest that there are metabolic relationships between the activities of the enzymes involved in polysaccharide degradation, the presence of intermediate metabolites and location along the digestive tract. Furthermore, we revealed that the anterior region of the gut plays an important role in the degradation of polysaccharides in the digestive tract of T. dichotomus larvae.