bluuebunny/crossref_metadata_2025_split huggingface dataset:
Host and viral determinants for efficient SARS-CoV-2 infection of the human lung
Authors: Chu Hin , Hu Bingjie , Huang Xiner , Chai Yue , Wang Yixin , Shuai Huiping , Yang Dong , Hou Yuxin , Zhang Xi , Yuen Terrence Tsz-Tai , Cai Jian-Piao , Zhang Anna Jinxia , Zhou Jie , Yuan Shuofeng , To Kelvin Kai-Wang , Chan Ivy Hau-Yee , Sit Ko-Yung , Foo Dominic Chi-Chun , Wong Ian Yu-Hong , Ng Ada Tsui-Lin , Cheung Tan To , Law Simon Ying-Kit , Au Wing-Kuk , Kok Kin-Hang , Chan Jasper Fuk-Woo , Yuen Kwok-Yung 
Published: July 2020

Abstract
SARS-CoV-2 has affected over 9 million patients with more than 460,000 deaths in about 6 months. Understanding the factors that contribute to efficient SARS-CoV-2 infection of human cells, which are not previously reported, may provide insights on SARS-CoV-2 transmissibility and pathogenesis, and reveal targets of intervention. Here, we reported key host and viral determinants that were essential for efficient SARS-CoV-2 infection in the human lung. First, we identified heparan sulfate as an important attachment factor for SARS-CoV-2 infection. Second, we demonstrated that while cell surface sialic acids significantly restricted SARS-CoV infection, SARS-CoV-2 could largely overcome sialic acid-mediated restriction in both human lung epithelial cells and ex vivo human lung tissue explants. Third, we demonstrated that the inserted furin-like cleavage site in SARS-CoV-2 spike was required for efficient virus replication in human lung but not intestine tissues. Overall, these findings contributed to our understanding on efficient SARS-CoV-2 infection of human lungs.
Long-term drug treatment of a giant liver hydatid cyst in a child
Authors: Velev Valeri , Donkov George , Mitova-Mineva Yordanka 
Published: July 2020

Abstract
BackgroundCystic еchinococcosis is a chronic parasitosis caused by the larvae of the tapeworm Echinococcus granulosus. Humans act as intermediate hosts and the larvae can affect any organ in the form of cysts. They are most often found incidentally by diagnostic imaging, where they have become large in size, with treatment being primarily invasive. Conservative treatment with albendazole is one of the appropriate treatment options, but it features a low success rate in cysts over 5 cm.Case presentationWe describe a case of an 14-year-old girl with an active 12 cm cyst in the liver. Two consecutive courses with albendazole, with duration 3 months each, were conducted. The cyst reached a safe inactive stage and no relapses have been observed for 1 year since the last administration of the medication.ConclusionsOur experience shows that with large cysts albendazole courses may be extended including in childhood. Ultrasonography has clearly demonstrated its ability to follow-up patient in a cost effective manner and avoiding ionizing radiations.
Frictional Properties of Anorthite (feldspar): Implications for the Lower Boundary of the Seismogenic Zone
Authors: Masuda Koji 
Published: July 2020

Abstract
Earthquake magnitude is closely related to the depth extent of the seismogenic zone, and higher magnitude earthquakes occur where the seismogenic zone is thicker. The frictional properties of the dominant mineral constituents of the crust, such as feldspar group minerals, control the depth extent of the seismogenic zone. Here, the velocity dependence of the steady-state friction of anorthite, a member of the feldspar mineral series, was measured at temperatures from 20 to 600 °C, pore pressures of 0 (“dry”) and 50 MPa (“wet”), and an effective pressure of 150 MPa. The results support previous findings that the frictional properties of feldspar play a dominant role in limiting the depth extent of the seismogenic zone. This evidence suggests that brittle deformation of anorthite may be responsible for brittle fault movements in the brittle–plastic transition zone.
Increasing Trends in the Prevalence of Prior Cancer in Newly Diagnosed Lung, Stomach, Colorectal, Breast, and Uterine Cancer Patients: A Population-Based Study
Authors: Sato Akira , Matsubayashi Keisuke , Morishima Toshitaka , Nakata Kayo , Kawakami Koji , Miyashiro Isao 
Published: July 2020

Abstract
Background: Cancer survivors are frequently excluded from clinical research, resulting in their omission from the development of many cancer treatment strategies. Quantifying the prevalence of prior cancer in newly diagnosed cancer patients can inform research and clinical practice. This study aimed to describe the prevalence, characteristics, and trends of prior cancer in newly diagnosed cancer patients in Japan.Methods: Using Osaka Cancer Registry data, we examined the prevalence, characteristics, and time trends of prior cancer in patients who received new diagnoses of lung, stomach, colorectal, female breast, or uterine cancer between 2004 and 2015. Site-specific prior cancers were examined for a maximum of 15 years before the new cancer was diagnosed. Time trends were evaluated using the Cochran-Armitage trend test.Results: Among 275,895 newly diagnosed cancer patients, 21,757 (7.9%) had prior cancer. The prevalence of prior cancer ranged from 3.3% (breast cancer) to 11.1% (lung cancer). In both sexes, the age-adjusted prevalence of prior cancer had increased in recent years (P values for trend < 0.001), especially in newly diagnosed lung cancer patients. The proportion of smoking-related prior cancers exceeded 50% in patients with newly diagnosed lung, stomach, colorectal, and breast cancer.Conclusions: The prevalence of prior cancer in newly diagnosed cancer patients is relatively high, and has increased in recent years. Our findings suggest that a deeper understanding of the prevalence and characteristics of prior cancer in cancer patients is needed to promote more inclusive clinical research and support the expansion of treatment options.
Contribution to The Peripheral Vasculopathy and Endothelial Cell Dysfunction by CXCL4 in Systemic Sclerosis
Authors: Jiang Zhixing , Chen Chen , Wang Lingbiao , Zhu Xiaoxia , Xue Yu , Kong Ning , Wan Weiguo , He Hang , Zou Hejian , Liang Minrui 
Published: July 2020

Abstract
Objective CXCL4, a chemokine with antiangiogenic property, is reported to be involved in systemic sclerosis (SSc) related pulmonary arterial hypertension (PAH). We investigated the contribution of CXCL4 to SSc development by focusing on the correlation of circulatory CXCL4 levels with their peripheral vasculopathy, as well as the effect of CXCL4 on endothelial cell dysfunction and angiogenesis disturbance in SSc and the potential signaling.Methods We measured the serum CXCL4 levels in 58 patients with SSc, 10 patients with the very early diagnosis of SSc (VEDOSS), and 80 healthy controls. Then, CXCL4 levels were correlated with their clinical features, especially the peripheral vasculopathy. These observations were further validated in an additional cohort including 50 SSc patients, 12 VEDOSS patients, and 80 healthy controls. Moreover, we studied the anti-angiogenesis effects and the underlying signaling of CXCL4 in human umbilical vein endothelial cells (HUVECs) in vitro. Results Circulating levels of the CXCL4 were 103.62% higher in patients with SSc and 201.51 % higher in patients with VEDOSS than matched HCs, and these observations were confirmed in two independent cohorts. CXCL4 levels were closely associated with digital ulcers (DU) and nailfold video capillaroscopy (NVC) abnormalities in SSc. The proliferation, migration, and tube formation of HUVECs were significantly inhibited by recombinant human CXCL4 or SSc derived serum, which reversed by CXCL4 neutralizing antibody, but not CXCR3 inhibitor. CXCL4 downregulated the transcription factor Friend leukaemia integration factor‐1 (Fli-1) via c-Abl signaling. Furthermore, CXCL4 blocked the transforming growth factor (TGF) -β or platelet-derived growth factor (PDGF) induced cell proliferation of HUVECs. Conclusions CXCL4 may contribute to peripheral vasculopathy in SSc by downregulating Fli-1 via c-Abl signaling in endothelial cells and interfering angiogenesis.
CHARACTER EDUCATION OF FOOD LOCAL CULTURE VALUES IN THE PEOPLE OF KAMPUNG ADAT CIRENDEU IN WEST JAVA THROUGH EXEMPLARY
Authors: Rohmatulloh Rohmatulloh , Aan Hasanah Aan Hasanah , Ruswandi Uus 
Published: July 2020

Customary village is small group of people who still survive and consistently preserve the culture and belief of their ancestors. Local cultural values deserve to be promoted to the application of character education in school. The qualitative research understanding the life and local cultural values is carried out in the people of Kampung Adat Cirendeu in West Java. The local culture of the Kampung Adat Cirendeu people holds the principle of ngindung ka waktu and mibapa ka jaman which has the meaning of maintaining identity but still keeping abreast of the times. One of the local cultural values that still preserves until today is the culture of cassava-based food as a substitute for rice. This culture has been going on for a century and become an inspiration for the national food diversification program. One of the preservation efforts is through the example of their ancestors. Promotion and granting food culture values to the character education in schools involve various educational stakeholders (teachers, educators, governments, people, and customary peoples) that should give an example to the students. The most effective method is to form students with character and in the end they will be familiar with local food culture and does not depend on rice. Keywords: Character education, Kampung Adat Cirendeu, Exemplary. PENDIDIKAN KARAKTER NILAI-NILAI BUDAYA LOKAL MAKANAN DI MASYARAKAT KAMPUNG ADAT CIRENDEU JAWA BARAT MELALUI KETELADANANDesa adat adalah sekelompok kecil orang yang masih bertahan dan secara konsisten melestarikan budaya dan kepercayaan nenek moyang mereka. Nilai-nilai budaya lokal layak dipromosikan untuk penerapan pendidikan karakter di sekolah. Penelitian kualitatif yang memahami kehidupan dan nilai-nilai budaya lokal ini dilakukan pada masyarakat Kampung Adat Cirendeu di Jawa Barat. Budaya lokal masyarakat Kampung Adat Cirendeu memegang prinsip ngindung ka waktu dan mibapa ka jaman yang memiliki makna mempertahankan identitas tetapi tetap mengikuti perkembangan zaman. Salah satu nilai budaya lokal yang masih dipertahankan hingga saat ini yaitu budaya makanan berbasis singkong sebagai pengganti beras. Budaya ini telah berlangsung selama satu abad dan menjadi inspirasi bagi program diversifikasi pangan nasional. Salah satu upaya pelestariannya yaitu melalui contoh dari nenek moyang mereka. Promosi dan pemberian nilai-nilai budaya makanan untuk pendidikan karakter di sekolah melibatkan berbagai pemangku kepentingan pendidikan (guru, pendidik, pemerintah, masyarakat, dan masyarakat adat) yang harus memberikan contoh kepada siswa. Metode yang paling efektif yaitu membentuk para siswa dengan karakter dan pada akhirnya mereka akan terbiasa dengan budaya makanan lokal dan tidak bergantung pada beras. Kata kunci: Pendidikan karakter, Kampung Adat Cirendeu, teladan.
Analysis of BKO Content (Antalgin and Dexamethasone) in Herbal Medicine Using Iodimetry Titration and HPLC Method
Authors: Ananto Agus Dwi , G Lalu Undrus Yusditia M. , A Lalu Sanik Wahyu F. 
Published: July 2020

Abstract : Misuse of adding chemical drugs – BKO – into herbal medicines is often done by irresponsible people. The aim is to increase efficacy instantly, to attract consumer interest. BKO, which are often added to herbal medicine, are antalgin and dexamethasone. Antalgin content analysis was carried out quantitatively using the iodimetry titration method by conducting a preliminary test. The dexamethasone content analysis was carried out with qualitative and quantitative methods. The qualitative method was carried out using TLC. The quantitative method was carried out using the HPLC technique. The results obtained for the analysis of antalgin content of 10 samples were obtained two samples of herbal medicine containing antalgin, respectively 0,0749% and 0,1083%. Analysis of the dexamethasone content from 10 samples obtained 5 herbal samples containing dexamethasone respectively 0.0979%, 0.222%, 0.4521%, 0.5131% and 0.2809%. So based on these results, it is necessary to take action from the relevant institution regarding the discovery of the content of BKO in the herbal medicine on the market in Lombok.Abstrak : Penyalahgunaan penambahan bahan kimia obat (BKO) kedalam jamu sering sekali dilakukan oleh oknum yang tidak bertanggung jawab. Hal ini dilakukan dengan tujuan meningkatkan khasiat secara instan, sehingga dapat menarik minat konsumen. BKO yang sering ditambahkan kedalam jamu adalah antalgin dan deksametason. Analisis kandungan antalgin dlakukan dengan cara kuantitatif menggunakan metode titrasi iodimetri dengan melakukan uji pendahuluan. Sedangkan analisis kandungan deksametason dilakukan dengan metode kualitatif dan kuantitatif. Metode kualitatif dilakukan dengan menggunakan KLT. Metode kuantitatif dilakukan dengan menggunakan teknik HPLC. Hasil yang diperoleh untuk analisis kandungan antalgin dari 10 sampel didapat 2 sampel jamu yang mengandung antalgin masing-masing sebesar 0,0749% dan 0,1083%. Analisis kandungan deksametason dari 10 sampel diperoleh 5 sampel jamu yang mengandung deksametason masing masing sebesar 0,0979%; 0,222%; 0,4521%; 0,5131% dan 0,2809%. Sehingga berdasarkan hasil tersebut maka perlu dilakukan adanya tindakan dari instansi terkait perihal masih ditemukannya kandungan BKO dalam sediaan jamu yang beredar di pasaran pulau Lombok.
Integrated Email Management System Based Google Application Programming Interface Using OAuth 2.0 Authorization Protocol
Authors: Musliyana Zuhar , Satira Andita Ghaitsa , Dwipayana Mahendar , Helinda Ayu 
Published: July 2020

Abstract : Google Apps is a service provided by Google that allows users to use Google products with their own domain names. Among the products offered by Google Apps are email (Gmail), Docs (Google Drive), and Classroom services. In addition, Google Apps also provides Application Programming Interface (API) services that can be used by developers to take advantage of various features provided by Google. Universitas Ubudiyah Indonesia (UUI) is one of the universities that use Google Apps service for managing student emails. At present, UUI student email management through Google Apps is still not integrated with academic information system data. As a result, UUI must allocate special resources for managing student emails manually. Based on these problems, this study proposes an integration system for UUI student email management using the Google Apps API. This system is designed using PHP programming. The Google Apps API authentication method uses OAuth 2.0. The results of this study indicate that student email management on Google Apps can be done through campus academic information systems. With this system, students can activate email independently without having to be registered manually to the Google Apps page by the campus email managers.Abstrak : Google Apps adalah sebuah layanan yang disediakan oleh Google yang memungkinkan pengguna dapat menggunakan produk google dengan nama domain sendiri. Di antaranya produk yang disediakan Google Apps yaitu layanan email (Gmail), dokumen (Google Drive), dan Classroom. Selain itu, Google Apps juga menyediakan layanan Application Programming Interface (API) yang dapat dimanfaatkan oleh pengembang untuk memanfaatkan berbagai layanan yang disediakan oleh Google. Universitas Ubudiyah Indonesia (UUI) merupakan salah satu universitas yang menggunakan layanan Google Apps untuk pengelolaan email mahasiswa. Saat ini pengelolaan email mahasiswa UUI melalui Google Apps masih belum terintegrasi dengan data sistem informasi akademik. Akibatnya UUI harus mengalokasikan sumber daya khusus untuk mengelola email mahasiswa secara manual. Berdasarkan permasalahan tersebut penelitian ini mengusulkan sistem integrasi pengelolaan email mahasiswa UUI menggunakan API Google Apps. Sistem ini dirancang menggunakan pemograman PHP. Metode autentikasi API Google Apps menggunakan OAuth 2.0. Hasil penelitian ini menunjukkan pengelolaan email mahasiswa pada Google Apps dapat dilakukan melalui sistem informasi akademik kampus. Dengan adanya sistem ini mahasiswa dapat melakukan aktivasi email secara mandiri tanpa harus didaftarkan secara manual ke halaman Google Apps oleh pengelola email kampus.
Usability Evaluation of Islamic Learning Mobile Applications
Authors: Bibi Syeda Hamna , Munaf Rumsha Muhammad , Bawany Narmeen Zakaria , Shamim Arifa , Saleem Zara 
Published: July 2020

Abstract : The trend of using mobile devices for the purpose of learning is gaining momentum. Apart from traditional education, various applications are being developed for religious learning. Pakistan is inhabited by around 98% of Muslims. Hence, the informal learning of Islam is essential for Muslim child development. This research presents a usability study of different Islamic learning mobile applications available on the android platform for children. The purpose of this research is to evaluate the usability of different Islamic learning mobile applications for children of diverse age groups in order to understand what design principles must be followed that increase the usability of the application. The main focus of this research is to observe and evaluate how easily children of different age groups respond to different applications, how effectively the children understand the core features of the applications and how easily they are able to use the application by themselves.
PENERAPAN PEMBELAJARAN DENGAN MENGGUNAKAN ALAT PERAGA PADA PEMBELAJARAN MATEMATIKA SMP
Authors: Sa’o Sofia 
Published: July 2020

This research was aimed to describe the effectiveness of the use of aids in mathematics instruction in SMP, with: 1) compare the mathematics learning achievement of students who were taught using real aids with that of students who were taught using half-real aids.; 2) compare the mathematics learning mastery of the students from both schools categories.This research is a quasi-experiment with pretest-postest design with non-equivalent groups. This research used two experiment groups and two control groups. Population of this research was fifth grade students of state SMP in Detusoko. Stratified random sampling technique was used to select the sample. From the population, the researcher took two schools and every school consisted of two classes as a sample. The total of the sample are 100 people. Data were collected using test. The test were tried out to two groups of students. To compare the mathematics learning achievement of students, data were analyzed by descriptive statistic and inferential statistic by analysis of covariant (α =0.05) and was continued with Tukey-Kramer test (α =0.05), while to compare the mathematics learning mastery of the students, data were analyzed by Chi-Square test.The result of this research showed that: 1) from both schools categories the mathematics learning achievement of students who were taught using real aids is higher than that of students taught using half-real aids; 2) the mathematics learning mastery of high category school students who were taught using real aids is higher than that of high category school students who were taught using half-real aids;3) the mathematics learning mastery of low category school students who were taught using real aids is not higher than that of low category school students who were taught using half-real aids; 4) from both schools categories the students who were taught using real aids, reach the mathematics learning mastery level, while the students who were taught using half-real aids, do not reach the learning mastery level.
The Impact of Two-Way Dialogue Strategy On Speaking Ability for Eleventh Grade Students of SMA Harapan 1 Medan
Authors: Juliana Juliana 
Published: July 2020

This research was proposed to gain whether there is a meaningful influence of applying a two-way dialogue on students' speaking ability. The research method was an experimental analysis in a quantitative approach. The sample of this research was eleventh-grade students of SMA Harapan 1 Medan which consisted of 60 students divided into two classes, the experimental and the control classes as representation consisting of 30 students in each class. Experimental group was taught using two-way dialogue strategy, while control group was taught conventional strategy. Data was gained using pre-test and post-test. A pre-test was administered to both groups before treatment and a post-test was administered after treatment. Then, the instrument applied to gather data was oral test in the design of short dialogue. To examine data, the researcher employed t-test. The result of the study was thatthe lowest the score of pre-test in experimental group was 69 and the highest score was 90. the lowest score of post-test was 75 and the highest score was 90. Futhermore, for control group, the lowest score of pre-test was 60 and the highest score was 80. while the lowest score of post-test was 65 and the highest score was 85. It means that two-way dialogue strategy had significantly influenced students' speaking ability.
Model Pengembangan Buku Ajar Pengayaan Membaca Seloko Adat Melayu Jambi di SMP
Authors: Kamarudin Kamarudin , Pahar Eddy 
Published: July 2020

Jambi memiliki seloko yang menarik baik isi maupun bentuknya. Pembelajaran, seloko Melayu di Jambi belum sepenuhnya dipelajari di dunia pendidikan, seperti yang dituntut oleh Kurikulum-13. Semestinya seloko direncanakan dalam pembelajaran di selokah. Berdasarkan survei yang dilaksanakan peneliti di daerah Batanghari, Jambi diperoleh sejumlah seloko Melayu. Seloko tersebut belum dirancang dengan baik sebagai bahan ajar bahasa dan sastra Indonesia di SMP, terutama dalam pembelajaran keterampilan membaca. Membaca adalah keterampilan penting yang wajib dikuasai oleh siswa. Kemampuan membaca bisa diperoleh melalui kegiatan latihan, tetapi keberadaan buku ajar sebagai penunjang penguasaan materi betul-betul diperlukan. Buku ajar menyediakan materi pembelajaran yang tersusun untuk keperluan guru dan siswa. Berdasarkan latar belakang masalah di atas, perlu dilakukan penelitian dan pengembangan buku ajar seloko yang mengintegrasikan seloko adat Jambi ke dalam Kurikulum-13, khusunya keterampilan membaca. Penelitian ini bertujuan menghasilkan buku ajar pengayaan membaca seloko yang sesuai dengan kebutuhan guru dan siswa. Metode yang digunakan dalam penelitian adalah metode deskriptif dengan teknik pengumpulan data seperti teknik ovservasi, teknik wawancara, dan analisis dokumen. Data di analisis berdasarkan langkah dikemukakan Milles (1984) yakni: (1) pengumpulan data, 2) reduksi data, (3) penyajian data, (4) simpulan. Pengembangan buku ajar, berdasarkan teori pengembangan Borg dan Gall (1983), yaitu; (1) survey awal (2) pengembangan draf, (3) pengujian draf (4) pengenalan produk.