bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reporting quality of systematic reviews with Moxibustion
Authors: Tian Ran , Zhang Xuan , Li Si-Yao , Aixinjueluo Qi-Ying , Lam Wai Ching , Bian Zhao-Xiang 
Published: June 2020

Abstract
Background: Moxibustion is one of the major interventions of Chinese medicine (CM). The systematic reviews (SRs) are essential references for evaluating the efficacy and safety of moxibustion interventions. This study aimed to assess the reporting quality of these SRs, particularly whether necessary information related to moxibustion was adequately reported.Methods: Five Databases (including Embase, Cochrane Library, MEDLINE, CNKI and VIP) were systematically searched for SRs of moxibustion that were published up to 31 December 2019. The primary analysis was to assess their reporting quality based on 27-item of the Preferred Reporting Items for SRs and Meta-Analyses (PRISMA) and 16-item of moxibustion-related information designed according to CM theory and the STRICTOM (STandards for Reporting Interventions in Clinical Trials Of Moxibustion). Descriptive statistics were also used to analyze their baseline characteristics.Results: A total of 97 SRs of moxibustion were identified from 2011 to 2019. For 27-item of PRISMA, except item 5, 8, 16 and 23, the remaining 23 items had the reporting compliances higher than 50%, of which 2 items (item 20 and 26) were fully reporting (100%). However, for moxibustion-related information, 69.1% (67/97) SRs did not provide the specific type of moxibustion, 39.2% (38/97) lacked details regarding the materials, procedure and technique used for moxibustion, 67.0% (65/97) did not report the selection criteria of acupoints for moxibustion, 28.9% (28/97) did not provide the number or duration of treatment sessions, 69.1% (67/97) did not provide any information about safety evaluation, and 94.8% (92/97) SRs did not report the treatment environment. For 51 (55.4%) of 92 SRs that included meta-analysis, it was impossible to assess whether meta-analysis had been properly conducted due to inadequate reporting of moxibustion interventions.Conclusion: The reporting quality of SRs of moxibustion need further improvements in terms of adequate reporting of moxibustion interventions and of moxibustion-related rationales. Reporting guideline of “PRISMA extension for moxibustion interventions” should be developed thus to improve their quality.
Prognostic value of neutrophil-to-lymphocyte ratio, lactate dehydrogenase, D-dimer and CT score in patients with COVID-19
Authors: Cai Yu-Qing , Zeng Hui-Qing , Zhang Xiao-Bin , Wei Xiao-Jie , Hu Lan , Zhang Zhen-Yu , Ming Quan , Peng Qiu-Ping , Chen Li-Da 
Published: June 2020

Abstract
Background

To explore the significance of neutrophil-to-lymphocyte ratio (NLR), lactate dehydrogenase (LDH), D-dimer and CT score in evaluating the severity and prognosis of coronavirus disease – 2019 (COVID-19).
Methods

Patients with laboratory confirmed COVID-19 were retrospectively enrolled. The baseline data, laboratory findings, chest computed tomography (CT) results evaluating by CT score on admission, and clinical outcomes were collected and compared. The logistic regression was used to assess the independent relationship between the baseline level of four indicators (NLR, LDH, D-dimer, CT score) and the severity of COVID-19.
Results

Among 432 patients, 125 (28.94%) cases were divided into severe group, the remaining (n = 307, 71.06%) were in non-severe group. In multivariate logistic regression, high level of NLR, LDH were independent predictor of the severe group in COVID-19 (OR = 2.163; 95%CI = 1.162–4.026; p = 0.015 for NLR > 3.82; OR = 2.298; 95%CI = 1.327–3.979; p = 0.003 for LDH > 246U/L). Combining NLR > 3.82 and LDH > 246U/L increased the sensitivity of diagnosis in severe patients (NLR > 3.82 [50.40%] vs. Combined diagnosis [72.80%]; p = 0.0007; LDH > 246 [59.2%] vs. Combined diagnosis [72.80%]; p < 0.0001).
Conclusions

High levels of NLR and LDH in serum have potential value in the early identification of severe patients with COVID-19. The combination of LDH and NLR can improve the sensitivity of diagnosis.
Infection deteriorating hepatitis B virus related acute-on-chronic liver failure: a retrospective cohort study
Authors: Zhai Xing-Ran , Tong Jing-Jing , Wang Hong-Min , Xu Xiang , Mu Xiu-Ying , Chen Jing , Liu Zi-Feng , Wang Yu , Su Hai-Bin , Hu Jin-Hua 
Published: June 2020

Abstract
Background: Infection is common in acute-on-chronic liver failure (ACLF), which may worsen the clinical condition and prognosis. However, the characteristics of infection and its influence on prognosis in hepatitis B virus related ACLF (HBV-ACLF) as defined by the European Association for the Study of the Liver (EASL) have not been clarified. We aimed to investigate the characteristics of infection and its influence on mortality in HBV-ACLF defined by EASL in China.Methods: We performed a retrospective cohort study with HBV-ACLF patients defined by EASL in a single center from January 2015 to December 2017. Patients were divided into an infection group and a non-infection group. The incidence, sites, strains of infection, and risk factors for mortality were evaluated. Results: A total of 289 patients were included, of which 185 (64.0%) were diagnosed with an infection. The most common was pneumonia (55.7%), followed by spontaneous bacterial peritonitis (47.6%) and others. The gram-negative bacteria were the most frequent (58.3%). Patients with one, two, and three or more infection sites had a gradually increasing incidence of sepsis (P<0.01), sepsis shock (P<0.001), and ACLF-3 (P<0.05). One, two, and three or more strains were isolated in 86, 16, and 18 patients, who showed a growing incidence of sepsis (P<0.01) and sepsis shock (P<0.001). Infection was identified as an independent risk factor for 28-day mortality in HBV-ACLF patients. Infected patients showed a significantly higher 28-day mortality than those without (P<0.01), especially in patients with ACLF-3. Pneumonia and sepsis were identified as independent predictors of 28-day mortality for infected patients.Conclusions: Infection is associated with severe clinical course and high mortality in HBV-ACLF defined by EASL. The increased incidence of sepsis and sepsis shock was associated with an increased number of infection sites and isolated strains. Pneumonia and sepsis were independent predictors affecting mortality in HBV-ACLF patients with infection.
Temporal genetic variation and dispersal patterns of Aedes albopictus (Diptera: Culicidae) among three different temperature regions of China
Authors: Gao Jian , Zhang Hengduan , Guo Xiaoxia , Xing Dan , Dong YanDe , Lan CeJie , Wang Ge , Li ChaoJie , Li ChunXiao , Zhao TongYan 
Published: June 2020

Abstract
Background Aedes albopictus is an indigenous and primary vector for Dengue and Zika viruses in China. Compare with its insecticide resistance, biology, and vector competence; little was known about its genetic variation, corresponding to environmental variations. Thus, the present study aims to discuss how Ae. albopictus population varies among different temperatures regions of China and decipher its potential dispersal patterns.Methods The genetic variation and population structure of all 17 Ae. albopictus populations, collected from three temperature regions of China, were investigated with 11 microsatellite loci and mitochondrial COI gene.Results 11 pairs out of 44 isolated microsatellite markers were chosen for genotyping analysis with the average PIC value of 0.713, which was high polymorphism. The number of alleles was high for each population, with the ne value increased from the Temperate region (3.876) to the Tropical region (4.144). 25 COI Haplotypes were detected, and the highest diversity was observed among the Tropical region. The mean Ho value (ca. 0.557) of all temperature regions, was significantly lower than the mean He values (ca. 0.684), with nearly all populations significantly departed from the HWE test and displayed significant population expansion ( p-value < 0.05).Two genetically isolated groups and three Haplotype clades were evaluated via STRUCTURE and Haplotype phylogenetic analyses, with Tropical populations isolated from other regions, significantly. Meanwhile, the majority genetic variation of Ae. albopictus populations were detected within populations and individuals at 31.40% and 63.04%, respectively, via AMOVA test, and a relatively significant positive correlation was merely observed among populations from the temperate region via Isolation by distance (IBD) analysis (R2 = 0.6614, p = 0.048). Recent dispersions were observed among different Ae. albopictus populations and a total of four major migration trends were rebuilt between the Tropical and the other two regions with the high genetic flows (Nm>0.5). Environmental factors, especially temperature and rainfall, may be the leading cause of genetic diversity differences of different temperature regions. Conclusions Continuous dispersion contributes to the similarity of Ae. albopictus populations among different temperature regions, and environmental factors, especially temperature and rainfall, may be the leading cause of genetic variation.
Comparison of three lymph node staging systems in evaluating the prognosis of patients with pT3 esophageal squamous cell carcinoma
Authors: Liu Di-tian , Wang Lin-shuo , Chen Yu-ping , Chen Shao-bin 
Published: June 2020

Abstract
Background: To explore the prognostic value of three lymph node staging systems, including number of positive lymph nodes (pN), lymph node ratio (LNR), and log odds of positive lymph nodes (LODDS), in patients with pT3 stage esophageal squamous cell carcinoma (ESCC).Methods: Data from 1667 patients with pT3 stage ESCC who underwent surgical resection were reviewed. The log-rank test was used to assess the differences in overall survival (OS) between groups. Multivariate analysis was performed to identify independent prognostic factors. The receiver operating characteristic curve was used to assess the prognostic accuracy of the three staging methods.Results: The median survival time for the entire group was 48.0 months, and the 1-, 3- and 5-year OS rates were 83.9%, 55.1% and 66.6%, respectively. All three lymph node staging systems were significantly correlated with OS in univariate and multivariate analyses. However, LNR and LODDS staging systems could more accurately predict survival than the pN staging system in patients with < 15 lymph nodes dissected, while LODDS have the best prognostic homogeneity.Conclusions: All three staging systems could be used for prognostic assessment in pT3 stage ESCC. But LODDS staging system might be superior to the others due to its prognostic homogeneity.
Early Improvement of Left Ventricular Dyssynchrony After Percutaneous Coronary Intervention in Patients with Single Chronic Total Occlusion Vessel
Authors: Wang Shaoping , Li Shiying , Li Yijia , Zhao Yejing , Liu Tong , Cheng Shujuan , Peng Hongyu , Wu Zheng , Zhao Donghui , Zheng Bin , Liu Jinghua 
Published: June 2020

Abstract
Background

The effect of percutaneous coronary intervention (PCI) of chronic total occlusion (CTO) on left ventricular dyssynchrony was unclear.
Methods

Patients with one CTO vessel were included. Tissue Doppler imaging was used to assess the left ventricular dyssynchrony index (DI) in twelve segments before and after successful CTO PCI. Multiple regression was used to identify independent correlates of DI reduction.
Results

41 patients were included with the mean age of 65.88 years. 39(95.12%) had left ventricular DI more than 33. It decreased significantly from 67.48 ± 28.73 to 44.69 ± 23.90 (P < 0.01) after successful CTO PCI. PCI of infarct-relative CTO was associated with less percentage of DI reduction (Coefficient [Coef.], 25.60; 95% confidence interval [CI], 8.13–43.08; P < 0.01). Higher initial DI was associated with more percentage of DI reduction (Coef., -0.35; 95% CI, -0.67- -0.03; P = 0.03). Percentage of DI reduction was associated with ejection fraction (EF) improvement (Coef., -5.09; 95% CI, -7.45- -2.72; P < 0.01) with linear relationship (P < 0.01).
Conclusion

Left ventricular dyssynchrony was reduced early after successful CTO PCI, which predicted EF improvement. The association between dyssynchrony reduction and long-term benefits of CTO PCI are expected.
Complementary feeding patterns of Filipino infants and toddlers lack diversity, especially among children from poor households
Authors: Jacquier Emma F , Angeles-Agdeppa Imelda , Lenighan Yvonne , Toledo Marvin B , Capanzana Mario V 
Published: June 2020

Abstract
Consumption of nutritionally adequate complementary foods is essential for optimal growth and development of infants and toddlers, particularly in developing countries. The aim of this study was to describe percentages of consumption, energy contribution (6-23.9mo), and usual nutrient intakes (12-23.9mo) from complementary foods among Filipino infants and toddlers stratified by household wealth. Data from 1087 infants and toddlers from the 2013 National Nutrition Survey were included. Dietary intake data was assessed using a 24Hr recall and population food intakes were stratified into pre-defined wealth categories. Breast milk, infant formula, powdered milk and rice were the most commonly consumed foods and beverages across the age groups. Several differences in complementary feeding by wealth status were observed. Infants and toddlers from poor households reported significantly greater consumption of human milk, in comparison to those from the rich households who reported a significantly greater consumption of infant/toddler formula (P>0.05). A higher percentage of toddlers from rich households consumed protein-containing foods, cookies and cakes. There was no difference in fruit and vegetable consumption between wealth groups in 6-11.9mo and 18-23.9mo children. Human milk and formula were the top contributors to energy in 6.11.9mo and 12-17.9mo children, while rice was the top energy contributor in 18-23.9mo children. Intakes of protein, fat, vitamin C, B vitamins, vitamin D, vitamin E, iron and calcium were higher in 12-23.9mo children from rich households. Interventions are required to enable caregivers of young Filipino children to provide complementary foods of high nutritional quality, particularly among children from the poor households.
Mental distress and psychological disorders of Syrians in fragile Syria and multiple countries related to COVID-19
Authors: Kakaje Ameer , Fadel Ammar , Ghareeb Ayham , Zohbi Ragheed Al 
Published: June 2020

Abstract
Background:Syria has entered its ninth year of crisis which left millions of Syrians suffering from humanitarian crises. This study evaluates the mental health of Syrians living in Syria and who left the country due to war and living in different ten countries as evaluating their condition needs further study, particularly with Coronavirus disease of 2019 (COVID-19).Methods:Online questionnaires included SPTSS, K10, MSPSS, demographic, war- and COVID-19-related questions. This study included participants from 10 different countries and they were matched with Syrians according to age and gender as other variables could not be matched due to different standards between countries.Results:This study included 472 participants, of which 214 (45.3%) were males with a mean age of 29.1 ± 7.5). More participants from Syria suffered from reduced ability to earn money (P=0.007), and worried about being unable to provide food from COVID-19 (P=0.007) although they worried less about them getting infected (P=0.041). Participants from Syria declared higher PTSD scores than Syrians living in other countries (P=0.045), mainly among doctors. Interestingly, there was no significant difference in social support, days unable to work from distress in the past 4 weeks, and mental distress (K10) between Syrians living in Syria and other countries (P>0.05). Conclusions:Syrians in Syria suffered more than Syrians living in other countries. Providing food and reduced ability to earn were the major stress. They also had more PTSD symptoms and stress than Syrians and others in other countries.
APTIDÃO FÍSICA E FATORES DE RISCO CARDIOMETABÓLICOS EM ADOLESCENTES: UM ESTUDO LONGITUDINAL
Authors: Da Silva Paula Roldão , De Faria Waynne Ferreira , Da Silva Jadson Marcio , Dos Santos Géssika Castilho , De Oliveira Raphael Gonçalves , Neto Antonio Stabelini 
Published: June 2020

Os níveis de aptidão física dos adolescentes são um importante indicador de seu estilo de vida e podem prevenir o desenvolvimento de fatores de risco cardiometabólicos. Este estudo teve como objetivo comparar os fatores de risco cardiometabólicos em adolescente a partir das mudanças nos componentes de aptidão física relacionada à saúde após três anos de seguimento. Foram realizados testes motores segundo o manual do FITNESSGRAM (back-saver sit and reach; curl-up; push-up; e progressive aerobic cardiovascular endurance run) e foram avaliados os fatores de risco cardiometabólicos: circunferência de cintura; pressão arterial em repouso; HDL colesterol; triglicerídeos; e glicemia em jejum em dois momentos (2014 e 2017). Para comparar os fatores de risco cardiometabólicos a partir das mudanças dos componentes de aptidão física entre os períodos de acompanhamento foi aplicado o teste de Kruskal-Wallis ou ANOVA one-way. Foi observado melhora significativa dos componentes de AFRS com o passar dos anos, com exceção da aptidão cardiorrespiratória. Não foram identificadas diferenças estatísticas nos fatores de risco cardiometabólicos a partir da manutenção ou mudanças dos componentes de AFRS durante o período de acompanhamento.
Pengembangan Perangkat Pembelajaran pada Mata Kuliah Kimia Dasar Berdasarkan Kurikulum KKNI
Authors: Siregar Anggi Desviana 
Published: June 2020

<p>Penelitian pengembangan petunjuk praktikum berbasis<em> green chemistry</em> pada materi stoikiometri dilandaskan pada karakteristik peserta didik yang lebih menyukai metode praktikum, namun di sekolah belum memiliki petunjuk praktikum yang dapat menyesuaikan waktu pelaksanaan praktikum dengan jam pelajaran di sekolah. Metode pengembangan yang digunakan adalah metode ADDIE yang terdiri dari tahap <em>analyze</em>,<em> design</em>,<em> development</em>,<em> implementation</em>, dan<em> evaluations</em>. Produk divalidasi oleh dua dosen ahli materi dan dua dosen ahli media, kemudian dilakukan uji keterbacaan oleh guru dan peserta didik, dan diuji cobakan pada kelas kecil. Subjek uji keterbacaan yaitu satu guru mata pelajaran kimia serta tiga peserta didik kelas XI IPA SMA N 7 Semarang, dan subjek uji coba kelas kecil yaitu sembilan peserta didik kelas XI IPA SMA N 7 Semarang. Hasil penilaian validasi ahli materi didapatkan indeks validitas 0,902 dengan kategori sangat tinggi, dan penilaian validasi ahli media mendapat indeks validitas sebesar 0,984 dengan kategori sangat tinggi. Pada uji keterbacaan oleh guru didapatkan kategori sangat baik dengan presentase sebesar 96,47%. Pada uji keterbacaan oleh peserta didik didapatkan presentase sebesar 95,83% dengan kategori sangat baik. Respon peserta didik memperlihatkan kategori sangat baik dengan presentase sebesar 94,29%.</p>
Waterborne diarrhoeal infection risk from multiple water sources and the impact of an earthquake
Authors: Ito Yuri , Shrestha Malla Sadhana , Bhattarai Arun Prasad , Haramoto Eiji , Shindo Junko , Nishida Kei 
Published: June 2020

AbstractIn the Kathmandu Valley of Nepal, locals depend on multiple water sources due to the limited access to safe water, which is a great global concern regarding its impact on human health. This study aimed to compare the infection risk of diarrhoea from multiple water sources with different concentrations of Escherichia coli among water supply areas and evaluate the impact of changing water sources due to the Gorkha earthquake on the infection risk. The concentration of enteropathogenic E. coli was estimated in samples of piped water, jar water, groundwater, and tanker water, which were collected in the Valley. The volume of each water ingestion was determined based on a questionnaire survey and considering drinking and bathing sources. The highest estimated risk was observed for households drinking groundwater from shallow dug wells, followed by tanker water. The estimated risk implied the regional disparity due to various water sources with different quality. After the earthquake, the ratio of households drinking only jar water increased, and the estimated risk decreased. The damage on piped water supply, the decrease of tanker water availability and the decrease of residents’ trust in groundwater quality presumably enhanced the consumption of jar water despite its high price.
A two-layer improved invasive weed optimization algorithm for optimal operation of cascade reservoirs
Authors: Fang Guo-hua , Wu Cheng-jun , Liao Tao , Huang Xian-feng , Qu Bo 
Published: June 2020

Abstract
This paper proposes a two-layer improved invasive weed optimization (TIIWO) algorithm to overcome the disadvantages of the low quality of its initial population and the low optimization performance of IWO. The TIIWO algorithm includes dynamic corridor constraints (in its outer layer) and iterative reciprocating optimization (in its inner layer). The convergence of the TIIWO algorithm is achieved by minimizing the Schaffer function, which is characterized by its strong oscillatory behavior. In addition, the sensitivity of the main TIIWO parameters is analyzed using two methods, namely the revised Morris scheme and the Sobol index method. For experimental assessment, the TIIWO algorithm is firstly applied to a single reservoir. We investigate how the algorithm convergence is affected by four algorithm variants and parameter values. Then, the TIIWO algorithm is used to solve the problem of the optimal operation of cascade reservoirs. The results show that the TIIWO algorithm quickly and efficiently reaches the optimal operation of cascade reservoirs. In addition, this algorithm exhibits superior performance for high-dimensional, nonlinear and multi-constraint problems.