bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using constructed soils for green infrastructure – challenges and limitations
Authors: Deeb Maha , Groffman Peter M. , Blouin Manuel , Egendorf Sara Perl , Vergnes Alan , Vasenev Viacheslav , Cao Donna L. , Walsh Daniel , Morin Tatiana , Séré Geoffroy 
Published: September 2020

Abstract. With the rise in urban population comes a demand for solutions to offset environmental problems caused by urbanization. Green infrastructure (GI) refers to engineered features that provide
multiecological functions in urban spaces. Soils are a fundamental
component of GI, playing key roles in supporting plant growth, infiltration,
and biological activities that contribute to the maintenance of air and water
quality. However, urban soils are often physically, chemically, or
biologically unsuitable for use in GI features. Constructed Technosols (CTs),
consisting of mixtures of organic and mineral waste, are man-made soils
designed to meet specific requirements and have great potential for use in
GI. This review covers (1) current methods to create CTs adapted for various
GI designs and (2) published examples in which CTs have been used in GI. We
address the main steps for building CTs, the materials and which formulae
should be used to design functional CTs, and the technical constraints
of using CTs for applications in parks and square lawns, tree-lined streets,
green buffer for storm water management, urban farming, and reclaimed
derelict land. The analysis suggests that the composition and structure of
CTs should and can be adapted to available wastes and by-products and to
future land use and environmental conditions. CTs have a high potential to
provide multiple soil functions in diverse situations and to contribute to
greening efforts in cities (and beyond) across the world.
Quelle est la véritable surface du domaine vital des Tortues d’Hermann (Testudo hermanni Gmelin, 1789) ? Implications pour la conservation
Authors: BALLOUARD Jean-Marie , DELEUZE Simon , ANDREO Laura , ROZEC Fabien , THOMAS Nicolas , LAFFARGUE Périne , AFERIAT Magalie , BONNET Xavier , CATARD Antoine , CARON Sébastien 
Published: September 2020

L’estimation précise de la taille des domaines vitaux (DV) qu’occupent les individus d’une espèce est cruciale pour les gestionnaires. Elle permet de mieux définir la taille minimale des sites à protéger et de limiter la fragmentation des populations. Grâce à des suivis par radio-tracking menés sur l’ensemble de la saison d’activité, les domaines vitaux annuels de 165 Tortues d’Hermann (Testudo hermanni Gmelin, 1789) provenant de neuf sous-populations de France continentale ont été obtenus par la méthode des polygones convexes minimum (MCP). Les grands domaines vitaux mesurés sur plusieurs populations contrastent avec les données précédemment publiées sur le sujet. Notre étude montre que le DV d’une Tortue d’Hermann occupe environ neuf hectares (valeur médiane 5,2 ha) alors que la valeur moyenne de référence pour les populations françaises n’est que de deux hectares. Cette différence s’explique par les petites tailles d’échantillons obtenus sur de courtes périodes des études précédentes. Les suivis intensifs menés pendant 10 ans fournissent une vision plus réaliste de la taille des domaines vitaux. En accord avec la littérature, une grande variabilité interindividuelle se traduit par des valeurs extrêmes, éloignées des DV (0,6 ha à 95,0 ha). Globalement, la taille des DV augmente au printemps lorsque l’activité des individus est la plus importante et se stabilise pendant la saison estivale, voire en automne. Il est essentiel que l’établissement de zones de protection et de corridors prenne en compte ces nouvelles données, tout particulièrement les valeurs maximales (>15 ha). Seules les populations suffisamment grandes occupant des habitats diversifiés pourront s’adapter aux changements globaux et aux changements climatiques notamment. Protéger de grandes surfaces si possible connectées par des infrastructures dédiées (e.g. passages sous les routes) est une condition pour avoir une diversité génétique importante et une diversité de micro-habitats suffisante.
Experiencias ocultas: sobre lo humano en la Capilla de San José en Sevilla
Authors: Garcia Garcia Tomas , Montero-Fernandez Francisco Javier 
Published: September 2020

Resumen: Vivimos refugiados en mundos desdoblados que inventamos sin saberlo, en sus sombras naturales; y cuando la naturaleza no basta, lo corregimos con arquitectura, que es el arte y la técnica de las sombras arrojadas, un lugar al que sin duda pertenecemos de lleno. La luz nos es dada, la sombra no. El mundo que nos rodea se divide en dos mitades irreconocibles, la luz y las tinieblas, como inocente expresión de dos espacios aparentemente opuestos: el cielo y la tierra. Nacemos dándonos a la luz, pero vivimos refugiados en sus sombras negras. La humanidad busca con obsesión el encuentro con estas experiencias ocultas, para observar la vida desde el otro lado. Esta pequeña capilla del barroco sevillano, conserva oculta en el trasfondo de su masa un misterioso secreto. A través de los ojos de dos jóvenes estudiantes de arquitectura de los años 60, nos adentraremos en un mundo invisible y humano (figura 1).Abstract: We live as refugees in concentric worlds that we invent without know it, by their natural shadows; and when nature isn’t enough, we correct it with architecture which is the art and technique of those casting shadows, a place in which we undoubtedly belong to. Light is given to us, shadow is not. The world that surrounds us is divided into two unrecognizable halves, light and darkness, as an innocent expression of two opposing spaces: sky and earth. We are born giving ourselves to light, but we live sheltered in the darkness to which we belong, in their black shadows.
La ambigüedad de lo trágico: reflexión de la incidencia política, económica y social del cine en Colombia
Authors: Jimenez Alejandro 
Published: September 2020

Resumen: Una de las mayores dificultades que sufren los historiadores del cine (latinoamericano y colombiano en particular) es la falta de fuentes de información confiables, y la escasez de material histórico concluyente. En tal sentido, el presente documento se dirige a ampliar las indagaciones documentales sobre el fenómeno fílmico colombiano, por medio del análisis de la relación dialéctica entre el contexto nacional y las investigaciones históricas, estéticas y narrativas, consolidadas en proyectos cinematográficos nacionales y latinoamericanos; en este sentido, el objetivo fundamental es el reconocer de manera reflexiva la incidencia histórica, social, política y económica en el cine colombiano y su representación del entorno, concluyendo que el arte en general y el cine especialmente ha intentado reflexionar sobre las vicisitudes sociales y tal intención ha sido influida por factores externos como las condiciones económicas transnacionales o intereses desligados al quehacer cultural. Abstract: One of the greatest difficulties experienced by film historians (Latin American and Colombian in particular) is the lack of reliable sources of information and the shortage of conclusive historical material. In this regard, this document, through an extensive literature review, aims to expand documentary research on the Colombian film phenomenon, through the analysis of the dialectical relationship between the national context and historical, aesthetic and narrative research, consolidated in national and Latin American film projects; In this sense, the fundamental objective is to reflectively recognize the historical, social, political and economic impact on Colombian cinema and its representation of the environment.
Deslocamentos no espaço: representações da paisagem na pintura do século XXI no Brasil
Authors: Silva Francis Rodrigues da , Silveira Luciana Martha 
Published: September 2020

No século XXI, o conceito de paisagem e sua representação na pintura continuam se transformando, inclusive em produções brasileiras. Nelas, há um diálogo com a vivência na paisagem brasileira, seus biomas e processos urbanísticos desorganizados. A partir de experiências e deslocamento nesses espaços, os artistas produzem imagens abordando questões mostrando os impasses culturais do país. O objetivo desse artigo é investigar a relação entre a experiência de deslocamento no espaço com a representação da paisagem na produção de pintura do século XXI no Brasil, tratando dos processos artísticos envolvidos nessas produções. Para isso, serão observadas obras de artistas que tenham o deslocamento no espaço como parte do processo de produção de pintura como: Miguel Penha, David Almeida, Luiz Zerbini e Marina Rheingantz. Este artigo faz o uso de uma metodologia de pesquisa bibliográfica e de análise de imagens, fundamentada em processos artísticos, culturais, históricos e tecnológicos.
A synthetic biosensor to detect peroxisomal acetyl-CoA concentration for compartmentalized metabolic engineering
Authors: Huttanus Herbert M. , Senger Ryan S. 
Published: September 2020

Background
Sub-cellular compartmentalization is used by cells to create favorable microenvironments for various metabolic reactions. These compartments concentrate enzymes, separate competing metabolic reactions, and isolate toxic intermediates. Such advantages have been recently harnessed by metabolic engineers to improve the production of various high-value chemicals via compartmentalized metabolic engineering. However, measuring sub-cellular concentrations of key metabolites represents a grand challenge for compartmentalized metabolic engineering.

Methods
To this end, we developed a synthetic biosensor to measure a key metabolite, acetyl-CoA, in a representative compartment of yeast, the peroxisome. This synthetic biosensor uses enzyme re-localization via PTS1 signal peptides to construct a metabolic pathway in the peroxisome which converts acetyl-CoA to polyhydroxybutyrate (PHB) via three enzymes. The PHB is then quantified by HPLC.

Results
The biosensor demonstrated the difference in relative peroxisomal acetyl-CoA availability under various culture conditions and was also applied to screening a library of single knockout yeast mutants. The screening identified several mutants with drastically reduced peroxisomal acetyl-CoA and one with potentially increased levels. We expect our synthetic biosensors can be widely used to investigate sub-cellular metabolism and facilitate the “design-build-test” cycle of compartmentalized metabolic engineering.
Multiplexed Detection of Analytes on Single Test Strips with Antibody‐Gated Indicator‐Releasing Mesoporous Nanoparticles
Authors: Climent Estela , Biyikal Mustafa , Gröninger Delia , Weller Michael G. , Martínez‐Máñez Ramón , Rurack Knut 
Published: September 2020

AbstractRapid testing methods for the use directly at a point of need are expected to unfold their true potential especially when offering adequate capabilities for the simultaneous measurement of multiple analytes of interest. Considering the unique modularity, high sensitivity, and selectivity of antibody‐gated indicator delivery (gAID) systems, a multiplexed assay for three small‐molecule explosives (TATP, TNT, PETN) was thus developed, allowing to detect the analytes simultaneously with a single test strip at lower ppb concentrations in the liquid phase in <5 min using a fluorescence reader or a smartphone for readout. While the TNT and PETN systems were newly developed here, all the three systems also tolerated harsher matrices than buffered aqueous model solutions. Besides a single‐track strip, the outstanding modularity of the hybrid biosensor materials in combination with strip‐patterning technologies allowed us to obtain a multichannel strip in a straightforward manner, offering comparable analytical performance while allowing to be tailored even more to the user's need.
Investigation of the thermal behavior effect of the surrounding material environment on the swirling flame structure
Authors: Thamri Mohamed Ali , Zinoubi Jamil , Gannouni Soufien , Naffouti Taoufik 
Published: September 2020

SummaryThis paper is focusing on the numerical simulation of a swirling flame, resulting from the interaction of multiple fires, evolving in a free and unlimited environment. A typical system, formed by a central fire source surrounded by four heat sources, is used. Since the thermal characteristic of the surrounding sources is the main engine for the rotation of flame, a detailed study is performed by varying the heating flux of these sources. This study shows that an increase of the heating flux of surrounding sources has as a result an intensification of the penetrating air puffs through the openings between the surrounding four heat sources. These puffs tangentially drive the central flame, thus producing a marked improvement on the angular momentum. Moreover, this study shows that the flame height is strongly affected by the flame rotation. Moreover, two different aspects of the flame height evolution are observed from the flow visualization and the thermal and dynamic fields for the different cases studied.
MPI‐CDG from a hepatic perspective: Report of two Egyptian cases and review of literature
Authors: Abdel Ghaffar Tawhida Y. , Ng Bobby G. , Elsayed Solaf M. , El Naghi Suzan , Helmy Sarah , Mohammed Nermine , El Hennawy Ahmed , Freeze Hudson H. 
Published: September 2020

AbstractMPI‐CDG is a rare congenital disorder of glycosylation (CDG) which presents with hepato‐gastrointestinal symptoms and hypoglycemia. We report on hepatic evaluation of two pediatric patients who presented to us with gastrointestinal symptoms. Analysis of carbohydrate deficient transferrin (CDT) showed a Type 1 pattern and molecular analysis confirmed the diagnosis of MPI‐CDG. Oral mannose therapy was markedly effective in one patient but was only partially effective in the other who showed progressive portal hypertension.
A ranking of concurrent precipitation and wind events for the Iberian Peninsula
Authors: Hénin Riccardo , Ramos Alexandre M. , Pinto Joaquim G. , Liberato Margarida L. R. 
Published: September 2020

AbstractThe Iberian Peninsula (IP) is often affected by extreme precipitation and severe winds that are mostly associated with extratropical cyclones and their atmospheric fronts. ERA5 reanalysis data are used to revise and update two existing rankings of extreme precipitation and extreme potential wind‐loss days for the extended winter months on the IP. A ranking of concurrent precipitation and wind extreme events is produced by matching the two individual rankings for the IP and for specific IP subregions, including its main river basins. The intensity and the variability at the interannual and decadal scale are evaluated for precipitation, wind and concurrent precipitation and wind events. A systematic analysis of the underlying synoptic conditions is pursued for the top100 most extreme concurrent events including (a) cyclones' trajectories, (b) the presence of an Atmospheric River (AR), (c) recurrent patterns in the locations affected by precipitation and wind extremes and (d) possible long‐term trends. Results show that 85% of concurrent precipitation and wind extreme events are clearly associated with a cyclonic feature and most of these cyclones either cross the IP or pass to the northwest. Concurrent events are more likely occurring in the northwestern sectors of the IP on wintertime as in recent decades a downward trend for the events' frequency is observed in autumn. ARs are more likely associated with the strongest events occurring on the western sector of IP. Accordingly, the areas that mostly experience concurrent precipitation and wind extremes related to those systems are located in the northwestern sector of the peninsula.
On‐Chip Acousto Thermal Shift Assay for Rapid and Sensitive Assessment of Protein Thermodynamic Stability
Authors: Ding Yonghui , Ball Kerri A. , Webb Kristofor J. , Gao Yu , D'Alessandro Angelo , Old William M. , Stowell Michael H. B. , Ding Xiaoyun 
Published: September 2020

AbstractThermal shift assays (TSAs) have been extensively used to study thermodynamics of proteins and provide an efficient means to assess protein–ligand binding or protein–protein interactions. However, existing TSAs have limitations, such as being time consuming, labor intensive, or having low sensitivity. Herein, an acousto thermal shift assay (ATSA), the first ultrasound enabled TSA, is reported for real‐time analysis of protein thermodynamic stability. It capitalizes the coupling of unique acoustic mechanisms to achieve protein unfolding, concentration, and measurement on a single microfluidic chip within minutes. Compared to conventional TSA methods, the ATSA technique enables ultrafast (at least 30 times faster), highly sensitive (7–34 folds higher), and label‐free monitoring of protein–ligand interactions and protein stability. ATSA paves new avenues for protein analysis in biology, medicine, and fast diagnosis.
4d mirror-like dualities
Authors: Hwang Chiung , Pasquetti Sara , Sacchi Matteo 
Published: September 2020

Abstract
We construct a family of 4d$$ \mathcal{N} $$
N
= 1 theories that we call $$ {E}_{\rho}^{\sigma } $$

E
ρ
σ

[USp(2N)] which exhibit a novel type of 4d IR duality very reminiscent of the mirror duality enjoyed by the 3d$$ \mathcal{N} $$
N
= 4 $$ {T}_{\rho}^{\sigma } $$

T
ρ
σ

[SU(N)] theories. We obtain the $$ {E}_{\rho}^{\sigma } $$

E
ρ
σ

[USp(2N)] theories from the recently introduced E[USp(2N )] theory, by following the RG flow initiated by vevs labelled by partitions ρ and σ for two operators transforming in the antisymmetric representations of the USp(2N) × USp(2N) IR symmetries of the E[USp(2N)] theory. These vevs are the 4d uplift of the ones we turn on for the moment maps of T[SU(N)] to trigger the flow to $$ {T}_{\rho}^{\sigma } $$

T
ρ
σ

[SU(N)]. Indeed the E[USp(2N)] theory, upon dimensional reduction and suitable real mass deformations, reduces to the T[SU(N)] theory. In order to study the RG flows triggered by the vevs we develop a new strategy based on the duality webs of the T[SU(N)] and E[USp(2N)] theories.
Synthesis and characterization of bio-based quaternary ammonium salts with gibberellate or l-tryptophanate anion
Authors: Szymaniak Daria , Pernak Juliusz , Rzemieniecki Tomasz , Kaczmarek Damian Krystian , Andrzejak Roman , Kosiada Tomasz , Janowska Beata 
Published: September 2020

AbstractNumerous biologically active acids can be transformed into an ionic form in a facile way and combined with appropriate quaternary ammonium cation to improve their application properties or biological activity. This study describes the synthesis of new quaternary ammonium salts with anions of gibberellic acid, a common plant growth regulator from the gibberellin group, orl-tryptophan, an important precursor of auxin biosynthesis. The surface-active tetrapentylammonium ion and natural substances such as acetylcholine, choline, and quinine were the sources of cations. Novel salts of gibberellic acid andl-tryptophan were obtained with high yields exceeding 97% as a result of the metathesis reaction or the neutralization of quaternary ammonium hydroxides. Phase transition temperatures, thermal and chemical stability, and solubility in solvents with different polarities were determined for all obtained salts. On the basis of studies regarding the influence of synthesized salts on the post-harvest longevity and quality of leaves ofConvallaria majalis, it was established that the biological activity of the natural plant regulators in most cases was maintained. Therefore, it can be concluded that the conversion of the active substance into the form of a quaternary ammonium salt results in obtaining novel forms of plant growth regulators with favourable physicochemical properties while maintaining the efficacy of the biological active ingredients.Graphic abstract
A deference model of epistemic authority
Authors: Bokros Sofia Ellinor 
Published: September 2020

AbstractHow should we adjust our beliefs in light of the testimony of those who are in a better epistemic position than ourselves, such as experts and other epistemic superiors? In this paper, I develop and defend a deference model of epistemic authority. The paper attempts to resolve the debate between the preemption view and the total evidence view of epistemic authority by taking an accuracy-first approach to the issue of how we should respond to authoritative and expert testimony. I argue that when we look at the debate through the lens of accuracy, it becomes clear that matters are more complicated than either the preemption view or the total evidence view are able to account for. Consequently, a deference model, outlined within a credence-based framework, does a better job of capturing the relevant phenomena, and explaining how we should update our beliefs in response to epistemically authoritative testimony.
iGMDR: Integrated Pharmacogenetic Resource Guide to Cancer Therapy and Research
Authors: Chen Xiang , Guo Yi , Chen Xin 
Published: September 2020

Abstract
Current pharmacogenetic studies have obtained many genetic models that can predict the therapeutic efficacy of anticancer drugs. Although some of these models are of crucial importance and have been used in clinical practice, these very valuable models have not been well adopted into cancer research to promote the development of cancer therapies due to the lack of integration and standards for the existing data of the pharmacogenetic studies. For this purpose, we built a resource investigating genetic model of drug response (iGMDR), which integrates the models from in vitro and in vivo pharmacogenetic studies with different omics data from a variety of technical systems. In this study, we introduced a standardized process for all integrations, and described how users can utilize these models to gain insights into cancer. iGMDR is freely accessible at https://igmdr.modellab.cn.
The importance of timely diagnosis of aspirin‐exacerbated respiratory disease for patient health and safety
Authors: Buchheit Kathleen , Bensko Jillian C. , Lewis Erin , Gakpo Deborah , Laidlaw Tanya M. 
Published: September 2020

BackgroudAspirin‐exacerbated respiratory disease (AERD) is a difficult‐to‐treat syndrome where timely diagnosis and initiation of disease‐specific therapies are pertinent to improved patient outcomes.ObjectiveTo characterize the most common timeline for development of the clinical triad [asthma, nasal polyposis, and reactions to nonsteroidal anti‐inflammatory drugs (NSAIDs)], identify barriers to prompt diagnosis of AERD, and describe indications for an aspirin challenge to facilitate accurate diagnosis.MethodsSix hundred ninety‐seven patients with diagnosed AERD and history of at least one sinus surgery to remove nasal polyps were identified in the Brigham and Women's Hospital AERD registry. Patient reported age at disease onset of asthma, nasal polyposis, and age of first NSAID reaction were obtained from 2013 to 2019 at enrollment.ResultsOf the 697 patients identified, diagnosis of asthma preceded diagnosis of nasal polyposis and first NSAID reaction, although there was considerable variability between patients.ConclusionsPrompt diagnosis of AERD is important for patient and provider education and improved care of this difficult‐to‐treat population of patients. Consider diagnostic aspirin challenge in patients without historical reactions to NSAIDs who have an otherwise compatible clinical history, specifically in patients who take daily low‐dose aspirin, leukotriene modifiers, avoid NSAIDs, or who are severely symptomatic at baseline where it would be difficult to identify an acute worsening of symptoms.