bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consistency and identifiability of football teams: a network science perspective
Authors: Garrido D. , Antequera D. R. , Busquets J. , López del Campo R. , Resta Serra R. , Jos Vielcazat S. , Buldú J. M. 
Published: November 2020

AbstractWe investigated the ability of football teams to develop a particular playing style by looking at their passing patterns. Using the information contained in the pass sequences during matches, we constructed the pitch passing networks of teams, whose nodes are the divisions of the pitch for a given spatial scale and links account for the number of passes from region to region. We translated football passings networks into their corresponding adjacency matrices. We calculated the correlations between matrices of the same team to quantify how consistent the passing patterns of a given team are. Next, we quantified the differences with other teams’ matrices and obtained an identifiability parameter that indicates how unique are the passing patterns of a given team. Consistency and identifiability rankings were calculated during a whole season, allowing to detect those teams of a league whose passing patterns are different from the rest. Furthermore, we found differences between teams playing at home or away. Finally, we used the identifiability parameter to investigate what teams imposed their passing patterns over the rivals during a given match.
A retrospective analysis of the relationship between anti-cyclic citrullinated peptide antibody and the effectiveness of abatacept in rheumatoid arthritis patients
Authors: Kida Daihei , Takahashi Nobunori , Kaneko Atsushi , Hirano Yuji , Fujibayashi Takayoshi , Kanayama Yasuhide , Hanabayashi Masahiro , Yabe Yuichiro , Takagi Hideki , Oguchi Takeshi , Kato Takefumi , Funahashi Koji , Matsumoto Takuya , Ando Masahiko , Kuwatsuka Yachiyo , Tanaka Eiichi , Yasuoka Hidekata , Kaneko Yuko , Hirata Shintaro , Murakami Kosaku , Sobue Yasumori , Nishiume Tsuyoshi , Suzuki Mochihito , Yokota Yutaka , Terabe Kenya , Asai Shuji , Ishiguro Naoki , Kojima Toshihisa 
Published: November 2020

AbstractThis study aimed to evaluate the effectiveness of abatacept (ABA) by anti-cyclic citrullinated peptide (ACPA) status on disease activity as well as radiographic progression in patients with rheumatoid arthritis (RA) in clinical settings. A retrospective cohort study was conducted using data from a multicenter registry. Data from a total of 553 consecutive RA patients treated with intravenous ABA were included. We primarily compared the status of disease activity (SDAI) and radiographic progression (van der Heijde modified total Sharp score: mTSS) between the ACPA-negative (N = 107) and ACPA-positive (N = 446) groups. ‘ACPA positive’ was defined as ≥ 13.5 U/mL of anti-CCP antibody. Baseline characteristics between groups were similar. The proportion of patients who achieved low disease activity (LDA; SDAI ≤ 11) at 52 weeks was significantly higher in the ACPA-positive group. Multivariate logistic regression analysis identified ACPA positivity as an independent predictor for achievement of LDA at 52 weeks. Drug retention rate at 52 weeks estimated by the Kaplan–Meier curve was significantly higher in the ACPA-positive group. Achievement rate of structural remission (ΔmTSS ≤ 0.5) at 52 weeks was similar between groups. ABA treatment demonstrated a significantly higher clinical response and higher drug retention rate in ACPA-positive patients. Progression of joint destruction was similar between the ACPA-negative and ACPA-positive groups. Close attention should be paid to joint destruction even in patients showing a favorable response to ABA, especially when the ACPA status is positive.
Extended-spectrum β-lactamase-producing Escherichia coli isolated from raw vegetables in South Korea
Authors: Song Jihyun , Oh Sung-Suck , Kim Junghee , Shin Jinwook 
Published: November 2020

AbstractThe increasing prevalence of oxyimino-cephalosporin-resistant Enterobacteriaceae has become a global concern because of their clinical impact on both human and veterinary medicine. The present study determined the prevalence, antimicrobial susceptibility, and molecular genetic features of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (ESBL-EC) isolates from raw vegetables. A total of 1324 samples were collected from two agricultural wholesale markets in Incheon, South Korea in 2018. The ESBL-EC strains were isolated from 0.83% (11/1324) samples, and all of them were resistant to ampicillin, piperacillin, cefazoline, cefotaxime, and nalidixic acid and yielded CTX-M-type ESBL, including CTX-M-14, CTX-M-15, CTX-M-55, CTX-M-27, and CTX-M-65. The isolates belonged to phylogenetic subgroups D (n = 5), A (n = 4), and B1 (n = 2). Multilocus sequence typing revealed nine known E. coli sequence types (STs), including ST10, ST38, ST69, ST101, ST224, ST349, ST354, ST2509, ST2847, and two new STs. Notably, ST69, ST10, ST38, and ST354 belong to the major human-associated extraintestinal pathogenic E. coli lineages. Our results demonstrate that ESBL-producing multidrug-resistant pathogens may be transmitted to humans through the vegetable intake, highlighting the importance of resistance monitoring and intervention in the One Health perspective.
WNK regulates Wnt signalling and β-Catenin levels by interfering with the interaction between β-Catenin and GID
Authors: Sato Atsushi , Shimizu Masahiro , Goto Toshiyasu , Masuno Hiroyuki , Kagechika Hiroyuki , Tanaka Nobuyuki , Shibuya Hiroshi 
Published: November 2020

Abstractβ-Catenin is an important component of the Wnt signalling pathway. As dysregulation or mutation of this pathway causes many diseases, including cancer, the β-Catenin level is carefully regulated by the destruction complex in the Wnt signalling pathway. However, the mechanisms underlying the regulation of β-Catenin ubiquitination and degradation remain unclear. Here, we find that WNK (With No Lysine [K]) kinase is a potential regulator of the Wnt signalling pathway. We show that WNK protects the interaction between β-Catenin and the Glucose-Induced degradation Deficient (GID) complex, which includes an E3 ubiquitin ligase targeting β-Catenin, and that WNK regulates the β-Catenin level. Furthermore, we show that WNK inhibitors induced β-Catenin degradation and that one of these inhibitors suppressed xenograft tumour development in mice. These results suggest that WNK is a previously unrecognized regulator of β-Catenin and a therapeutic target of cancer.
Analyzing protein dynamics from fluorescence intensity traces using unsupervised deep learning network
Authors: Yuan Jinghe , Zhao Rong , Xu Jiachao , Cheng Ming , Qin Zidi , Kou Xiaolong , Fang Xiaohong 
Published: November 2020

AbstractWe propose an unsupervised deep learning network to analyze the dynamics of membrane proteins from the fluorescence intensity traces. This system was trained in an unsupervised manner with the raw experimental time traces and synthesized ones, so neither predefined state number nor pre-labelling were required. With the bidirectional Long Short-Term Memory (biLSTM) networks as the hidden layers, both the past and future context can be used fully to improve the prediction results and can even extract information from the noise distribution. The method was validated with the synthetic dataset and the experimental dataset of monomeric fluorophore Cy5, and then applied to extract the membrane protein interaction dynamics from experimental data successfully.
Anti-apoptotic BCL-2 regulation by changes in dynamics of its long unstructured loop
Authors: Lan Yu-Jing , Yeh Pei-Shan , Kao Te-Yu , Lo Yuan-Chao , Sue Shih-Che , Chen Yu-Wen , Hwang Dennis W. , Chiang Yun-Wei 
Published: November 2020

AbstractBCL-2, a key protein in inhibiting apoptosis, has a 65-residue-long highly flexible loop domain (FLD) located on the opposite side of its ligand-binding groove. In vivo phosphorylation of the FLD enhances the affinity of BCL-2 for pro-apoptotic ligands, and consequently anti-apoptotic activity. However, it remains unknown as to how the faraway, unstructured FLD modulates the affinity. Here we investigate the protein-ligand interactions by fluorescence techniques and monitor protein dynamics by DEER and NMR spectroscopy tools. We show that phosphomimetic mutations on the FLD lead to a reduction in structural flexibility, hence promoting ligand access to the groove. The bound pro-apoptotic ligands can be displaced by the BCL-2-selective inhibitor ABT-199 efficiently, and thus released to trigger apoptosis. We show that changes in structural flexibility on an unstructured loop can activate an allosteric protein that is otherwise structurally inactive.
Tet2 at the interface between cancer and immunity
Authors: Jiang Shuai 
Published: November 2020

AbstractKeeping a balance between DNA methylation and demethylation balance is central for mammalian development and cell function, particularly in the hematopoietic system. In various mammalian cells, Tet methylcytosine dioxygenase 2 (Tet2) catalyzes oxygen transfer to a methyl group of 5-methylcytosine (5mC), yielding 5-hydroxymethylcytocine (5hmC). Tet2 mutations drive tumorigenesis in several blood cancers as well as in solid cancers. Here I discuss recent studies that elucidate mechanisms and biological consequences of Tet2 dysregulation in blood cancers. I focus on recent findings concerning Tet2 involvement in lymphoid and myeloid cell development and its functional roles, which may be associated with tumorigenesis. I also discuss how Tet2 activities are modulated by microRNAs, metabolites, and other interactors, including vitamin C and 2-hydroxyglutarate (2-HG), and review the clinical relevance and potential therapeutic applications of Tet2 targeting. Finally, I propose key unanswered hypotheses regarding Tet2 in the cancer-immunity cycle.
Mex3c mutation affects lactation through impairing milk ejection in female mice
Authors: Du Yong , Sun Dongjun , Li Yan 
Published: November 2020

Abstract
Mouse Mex3c encodes RNA-binding proteins of variant length through alternative splicing. Its mutation results in multiple defects including growth retardation, perturbed energy balance, and defective antiviral innate immunity. Here we report that Mex3c mutation affects mammary gland development and lactation in female mice. Pups of Mex3c mutant dams die of starvation soon after birth. Milk contents are present in the alveoli but deficient in the ducts of the mammary glands in mutant mice. Mutant mice do not show prolactin or oxytocin deficiency. They also develop myoepithelial cells in the mammary glands. Mex3c is expressed in the mammary gland epithelium. Our data suggest that functional defects in mammary gland epithelium or myoepithelial cells could cause lactation defects.
Phonological priming in German Sign Language
Authors: Wienholz Anne , Nuhbalaoglu Derya , Steinbach Markus , Herrmann Annika , Mani Nivedita 
Published: November 2020

AbstractA number of studies provide evidence for a phonological priming effect in the recognition of single signs based on phonological parameters and that the specific phonological parameters modulated in the priming effect can influence the robustness of this effect. This eye tracking study on German Sign Language examined phonological priming effects at the sentence level, while varying the phonological relationship between prime-target sign pairs. We recorded participants’ eye movements while presenting videos of sentences containing either related or unrelated prime-target sign pairs, and pictures of the target and an unrelated distractor. We observed a phonological priming effect for sign pairs sharing handshape and movement while differing in location parameter. Taken together, the data suggest a difference in the contribution of sign parameters to sign recognition and that sub-lexical features influence sign language processing.
Pearlitic structure and wear properties of graphite cast iron reinforced with biphase TiC-TiB2 nanoparticles
Authors: Wang Bingxu , Cui Weiwei , Qiu Feng , Du Wenhui , Chen Yuanbin , Barber Gary C 
Published: November 2020

Abstract
The current research describes the preparation of nanoparticle-reinforced ductile iron specimens through an aluminum master alloy containing bi-phase TiC-TiB2 nanoparticles. The pearlitic structure, hardness and wear resistance were examined and compared for ductile iron specimens with and without nanoparticles. It was found that the presence of a small amount of TiC-TiB2 nanoparticles could refine the lamellar structure of pearlite, increase the hardness and lower the wear loss under dry and lubricated test conditions. Adhesion with plastic flow, material removal and material smearing were reduced on the wear track which was associated with the coupled effects of finer pearlite and higher hardness after engaging the TiC-TiB2 nanoparticles. In addition, it was found that the nanoparticles were distributed on the worn areas, which could withstand the normal load and minimize the contact between the ductile iron substrate and counterface during the wear tests.
Plasmon recombination in narrowgap HgTe quantum wells
Authors: Aleshkin V Ya , Alymov G , Dubinov A A , Gavrilenko V I , Teppe F 
Published: November 2020

Abstract
The dispersion laws of two-dimensional plasmons in narrow-gap HgTe/CdHgTe quantum wells are calculated taking into account the spatial dispersion of the electron susceptibility. At the energy scale of the band gap the dependence of plasmon frequencies on the wave vector is shown to be close to linear that changes significantly the critical concentration of noneqilibrium electron-hole gas corresponding to ‘switching-on’ the carrier recombination with plasmon emission. The recombination rates with the plasmon emission have been calculated. The ‘plasmon’ recombination is shown to dominate at the carrier concentration over (1.2–2) 1011 cm−2 in a 5-nm-wide HgTe quantum well (band gap of 35 meV) that makes plasmon generation (spasing) in THz frequency range feasible.
Iron and nitrogen-doped double gyroid mesoporous carbons for oxygen reduction in acidic environments
Authors: Matsuoka Fumiaki , Fritz Kevin E , Beaucage Peter A , Yu Fei , Suntivich Jin , Wiesner Ulrich 
Published: November 2020

Abstract
Iron- and nitrogen-doped carbon (Fe-N-C) represents a promising class of alternative electrocatalysts to noble metals for the oxygen reduction reaction (ORR) in acidic environments. To make Fe-N-C active, one of the most critical parameters is microporosity, which must be controlled to maximize the active site density. However, the use of microporosity must be optimized for the requirement of high-flux mass transport. Here, we synthesized and demonstrated gyroidal mesoporous Fe-N-C with microporous pore walls as an avenue to combine a high active-site density with favorable mass transport at high flux. The gyroidal mesoporous Fe-N-C catalysts have competitive gravimetric and volumetric ORR activities, comparable to the ORR activity obtained in purely microporous configurations despite having mesoporous features. Our result suggests that the ORR activity of microporous Fe-N-C electrocatalysts can be combined with mesoporosity through the use of mesoporous Fe-N-C with microporous pore walls. We further investigate effects of the nitrogen incorporation method on mesoporous N-doped carbon electrocatalysts. We find that despite having ∼2 × higher N concentration, nitrogen incorporation via NH3 yields similar ORR activity to incorporation via a chemical additive, a finding we attribute to the role of pyridinic and quaternary N in the ORR.
Study of the methylene blue adsorption mechanism using ZrO2/Polyaniline nanocomposite
Authors: Kumar Naresh , Bahl Tanya , Kumar Rajesh 
Published: November 2020

Abstract
ZrO2 (Zirconia) nanoparticles (NPs), PANI (polyaniline), and ZrO2/PANI nanocomposites (NCs) were successfully synthesized using CTAB (Hexadecyltrimethylammonium bromide) and SDS (Sodium dodecyl sulfate) surfactants by following the co-precipitation method. The structural phase analysis of as-prepared, annealed nanoparticles, and nanocomposites was done using the XRD (x-ray diffraction) technique. The crystallite size of pure SDS and CTAB assisted ZrO2 NPS comes out to be 19 and 17 nm, respectively. After the formation of NCs, the size has been reduced to 15.7 and 15.9 nm, respectively for the same samples. The effect of surfactants on the dye adsorption mechanism was studied using XRD and UV–vis spectroscopy. The prepared NPs and NCs were utilized as an adsorbent for the removal of organic dye methylene blue (MB) which is used as a model compound. UV–vis spectra of the supernatant solution were taken and studied to detect the relative decrease in the dye concentration with time. The as-prepared CTAB assisted ZrO2/PANI NCs show higher adsorption activity than annealed CTAB assisted ZrO2/PANI whereas a reversal trend in the adsorption activity was observed for SDS-assisted ZrO2/PANI NCs. Various kinetic models were implemented and correlated to the experimental data to elucidate the working mechanism for dye adsorption and to set up, a relation in the adsorption activity of surfactant modified NPs and NCs.
Concomitant prediction of environmental fate and toxicity of chemical compounds
Authors: Garcia-Martin Juan Antonio , Chavarría Max , de Lorenzo Victor , Pazos Florencio 
Published: November 2020

Abstract
The environmental fate of many functional molecules that are produced on a large scale as precursors or as additives to specialty goods (plastics, fibers, construction materials, etc.), let alone those synthesized by the pharmaceutical industry, is generally unknown. Assessing their environmental fate is crucial when taking decisions on the manufacturing, handling, usage, and release of these substances, as is the evaluation of their toxicity in humans and other higher organisms. While this data are often hard to come by, the experimental data already available on the biodegradability and toxicity of many unusual compounds (including genuinely xenobiotic molecules) make it possible to develop machine learning systems to predict these features. As such, we have created a predictor of the “risk” associated with the use and release of any chemical. This new system merges computational methods to predict biodegradability with others that assess biological toxicity. The combined platform, named BiodegPred (https://sysbiol.cnb.csic.es/BiodegPred/), provides an informed prognosis of the chance a given molecule can eventually be catabolized in the biosphere, as well as of its eventual toxicity, all available through a simple web interface. While the platform described does not give much information about specific degradation kinetics or particular biodegradation pathways, BiodegPred has been instrumental in anticipating the probable behavior of a large number of new molecules (e.g. antiviral compounds) for which no biodegradation data previously existed.
Current use of cardiac magnetic resonance in tertiary referral centres for the diagnosis of cardiomyopathy: the ESC EORP Cardiomyopathy/Myocarditis Registry
Authors: Mizia-Stec Katarzyna , Charron Philippe , Gimeno Blanes Juan Ramon , Elliott Perry , Kaski Juan Pablo , Maggioni Aldo P , Tavazzi Luigi , Tendera Michał , Felix Stephan B , Dominguez Fernando , Ojrzynska Natalia , Losi Maria-Angela , Limongelli Giuseppe , Barriales-Villa Roberto , Seferovic Petar M , Biagini Elena , Wybraniec Maciej , Laroche Cecile , Caforio Alida L P ,   the EORP Cardiomyopathy Registry Investigators
Published: November 2020

Abstract

Aims
Cardiac magnetic resonance (CMR) is recommended in the diagnosis of cardiomyopathies, but it is time-consuming, expensive, and limited in availability in some European regions. The aim of this study was to determine the use of CMR in cardiomyopathy patients enrolled into the European Society of Cardiology (ESC) cardiomyopathy registry [part of the EURObservational Research Programme (EORP)].

Methods and results
Three thousand, two hundred, and eight consecutive adult patients (34.6% female; median age: 53.0 ± 15 years) with cardiomyopathy were studied: 1260 with dilated (DCM), 1739 with hypertrophic (HCM), 66 with restrictive (RCM), and 143 with arrhythmogenic right ventricular cardiomyopathy (ARVC). CMR scans were performed at baseline in only 29.4% of patients. CMR utilization was variable according to cardiomyopathy subtypes: from 51.1% in ARVC to 36.4% in RCM, 33.8% in HCM, and 20.6% in DCM (P &lt; 0.001). CMR use in tertiary referral centres located in different European countries varied from 1% to 63.2%. Patients undergoing CMR were younger, less symptomatic, less frequently had implantable cardioverter-defibrillator (ICD)/pacemaker implanted, had fewer cardiovascular risk factors and comorbidities (P &lt; 0.001). In 28.6% of patients, CMR was used along with transthoracic echocardiography (TTE); 67.6% patients underwent TTE alone, and 0.9% only CMR.

Conclusion
Less than one-third of patients enrolled in the registry underwent CMR and the use varied greatly between cardiomyopathy subtypes, clinical profiles of patients, and European tertiary referral centres. This gap with current guidelines needs to be considered carefully by scientific societies to promote wider availability and use of CMR in patients with cardiomyopathies.
Surgicel mimicking early onset prosthetic valve endocarditis: case report
Authors: Regragui Hind , El Boussaadani Badre , Oukerraj Latifa , Rhissassi Jaafar 
Published: November 2020

Abstract

Background
Surgicel is one of the commercial forms of oxidized regenerated cellulose used as a bioabsorbable topical haemostatic agent during surgical procedures. However, its presence can mimic an abscess, tumour, lymph node or retained foreign body on imaging studies. The challenge in cardiac surgery is to differentiate the haemostatic material from an abscess that might be mistaken for an early onset prosthetic valve endocarditis.

Case summary
A 56-year-old woman was admitted to our department for a suspicion of early onset prosthetic valve endocarditis after an aortic valve replacement. An early clinical and biological improvement, features on a chest computed tomography scan, as well as a surgical correlation were able to rectify the diagnosis. The acute fever was linked to urinary tract infection, whereas the periaortic echogenic mass shown at the transoesophageal echocardiography corresponded to Surgicel.

Discussion
Oxidized regenerated cellulose can mimic an abscess on cardiac imaging, especially when used in excess during cardiac surgery. Fortunately, some radiographic features can help differentiate the haemostatic material from an abscess. Hence, sharing the use and location of Surgicel between the surgeon, radiologist, and cardiologist is very important and necessary to make the correct diagnosis.
Zero-contrast percutaneous coronary intervention for chronic total occlusions guided by intravascular ultrasound with ChromaFlo mode: a case report
Authors: Chen Chen-Yang , Huang Wei , Liu Jun , Cao Yu 
Published: November 2020

Abstract

Background
Contrast agent allergy may result in severe adverse events that prevent the use of percutaneous coronary intervention (PCI) in some patients, especially for those with complex lesions.

Case summary
We describe a 59-year-old man who presented with the multi-vessel disease and suffered from contrast allergy. The patient refused to have coronary artery bypass grafting surgery, thus two-stage PCI procedures without iodinated contrast media were performed after a detailed discussion with the heart team, including a chronic total occlusion (CTO) lesion in the proximal left anterior descending artery. The intravascular ultrasound (IVUS) was used for finding the entry point of the proximal fibre cap, and assessing the lesion, thereby marking the positions of the proximal and distal edges of the stent. After PCI, stent expansion and subtle edge dissection or incomplete apposition were confirmed by IVUS and ChromaFlo imaging. Zero-contrast PCI was done successfully without any complication.

Discussion
This case report illustrates the feasibility and safety of performing CTO-PCI without contrast agent in carefully and well prepared selected patients.