bluuebunny/crossref_metadata_2025_split huggingface dataset:
Injectable Nano‐Micron AKBA Delivery Platform for Treatment of Tendinopathy in a Rat Model
Authors: Han Qibin , Qian Yinhua , Bai Lang , Zhou Jing , Hao Yuefeng , Hu Dan , Zhang Zhouzhou , Yang Xing 
Published: December 2024

ABSTRACTTendinopathy is a disorder characterized by pain and reduced function due to a series of changes in injured or diseased tendons. Inflammation and collagen degeneration are key contributors to the onset and chronic nature of tendinopathy. Acetyl‐11‐keto‐β‐boswellic acid (AKBA) is an effective anti‐inflammatory agent widely used in chronic inflammatory disorders and holds potential for tendinopathy treatment; however, its therapeutic efficacy is limited by poor aqueous solubility. Here, we fabricated AKBA‐encapsulated cationic liposome‐gelatin methacrylamide (GelMA) microspheres (GM‐Lipo‐AKBA) using thin‐film hydration and microfluidic technology for drug delivery therapy. GM‐Lipo‐AKBA exhibited high encapsulation efficiency, extended AKBA release for over 4 weeks, and prolonged degradation. In vitro and in vivo experiments demonstrated its effectiveness in improving inflammation and ECM remodeling in tendinopathy. In summary, the injectable nano‐micron drug delivery platform provides a promising strategy for the sustained and localized delivery of AKBA for tendinopathy treatment.
Dextran Sulfate‐Modified and pH‐Responsive Nanoprobes for Magnetic Resonance/Fluorescence Dual‐Modality Imaging of Vulnerable Plaques
Authors: Cheng Jianing , Hao Liguo , Zhu Xiaorong , Ma Ruifan , Li Silong , Yin Qiangqiang , Wang Dongxu , Hu Haifeng , Zhang Tianyu , Li Zheng , Cong Houyi , Zheng Xiaoyang , He Jun , Wang Yuguang 
Published: December 2024

ABSTRACTTriggered by the vulnerability to atherosclerotic plaques, cardiovascular diseases (CVDs) have become a main reason for high mortality worldwide. Thus, there is an urgent need to develop functional molecular imaging modalities to improve the detection rate of vulnerable plaques. In this study, polyethyleneimine (PEI) was coated on the surface of mesoporous silica nanoprobes (MSN) loaded with Gd2O3 (MSN@Gd2O3), followed by coupling the fluorescent dye carboxylated heptamethine cyanine (IR808), and then the dextran sulfate (DS) was modified on the surface of MSN@Gd2O3@IR808 by electrostatic adsorption, to construct a targeted and pH‐responsive magnetic resonance (MR)/near‐infrared fluorescence imaging (NIRF) dual‐modal nanoprobe (MSN@Gd2O3@IR808@DS nanoparticles). The nanoprobe presented a more concentrated distribution of spherical shapes in transmission electron microscopy. In vitro simulated vulnerable plaque microenvironment (pH = 5.5) presented significant T1‐weighted imaging (T1WI) signal and longitudinal relaxation in the nanoprobe. Immunofluorescence staining and cellular uptake assays showed that MSN@Gd2O3@IR808@DS nanoparticles have the ability to specially bind to scavenger receptors A (SR‐A). In vascular endothelium from the high‐fat diet (HFD) New Zealand White rabbits, MSN@Gd2O3@IR808@DS nanoparticles can exhibit specific contrast‐enhanced signals by MR/NIRF dual‐modal imaging. In addition, cytotoxicity assays and hematoxylin and eosin (H&E) staining results demonstrated that MSN@Gd2O3@IR808@DS nanoparticles have good biocompatibility. Hence, this multifunctional MR/NIRF bimodal nanoprobe provides new experimental and technological ideas for the accurate diagnosis of vulnerable plaques.
Evaluation of Neurovascular Coupling in Early‐Onset and Late‐Onset Epilepsy of Unknown Etiology
Authors: Wan Xinyue , Yin Xuyang , Chai Xinyi , Tian Mei , Wang Jianhong , Zhang Jun 
Published: December 2024

BackgroundPrevious studies have shown neurovascular coupling (NVC) dysfunction in epilepsy, suggesting its role in the pathological mechanisms. However, it remains unclear whether NVC abnormalities exist in epilepsy of unknown etiology (EU).PurposeTo integrate multiparametric MRI to assess NVC and its relationship with cognition in early‐onset and late‐onset EU patients.Study TypeProspective.PopulationNinety‐six EU patients (46 early‐onset, M/F = 20/26; 50 late‐onset, M/F = 29/21) and 60 healthy controls (HCs, M/F = 25/35).Field Strength/Sequence3.0 T, resting‐state gradient echo‐planar imaging, pseudo‐continuous arterial spin labeling (pc‐ASL), and T1‐weighted brain volume sequence.AssessmentFunctional MRI data were analyzed to assess intrinsic brain activity including amplitude of low‐frequency fluctuations (ALFF), fractional ALFF (fALFF), regional homogeneity (ReHo), and functional connectivity strength (FCS), while pc‐ASL provided cerebral blood flow (CBF) measurements. Coupling correlation coefficients and ratios of CBF to neural activity were calculated to evaluate global and regional NVC.Statistical TestsTwo‐sample t‐test, Analysis of Variance, Kruskal–Wallis test, Chi‐square test, Analysis of Covariance, family‐wise error/Bonferroni correction, partial correlation analyses. Statistical significance was defined as P < 0.05.ResultsWhole‐brain analysis revealed increased ALFF values in both patient groups' left precentral and postcentral gyri. Both patient groups had lower global NVC coefficients than HCs, with reduced CBF‐ALFF (0.28 vs. 0.30), CBF‐fALFF (0.43 vs. 0.45), and CBF‐ReHo (0.40 vs. 0.41) in early‐onset patients, and lower CBF‐fALFF (0.38 vs. 0.45) and CBF‐ReHo (0.32 vs. 0.41) in late‐onset patients. Regional analysis showed significantly decreased CBF/ALFF ratios in the left precentral and postcentral gyri (T = 3.85 to 5.33). Reduced global NVC in early‐onset patients was significantly associated with poorer executive function (r = 0.323), while global coupling in late‐onset patients was negatively correlated with disease duration (r = −0.348 to −0.426).Data ConclusionThis study showed abnormal global and regional NVC in both early‐onset and late‐onset EU patients, emphasizing the potential role of NVC in the pathophysiological mechanisms of EU.Level of Evidence1Technical EfficacyStage 1
Driving under the influence of prescribed opioids: a qualitative study of the pharmacist's contribution to road safety
Authors: Gillett John Marius Harold , King Mark , Carroll Julie‐Anne , White Melanie 
Published: December 2024

AbstractBackgroundAustralia's 20‐year consistent fall in road crash fatalities has stalled. Concerning is the marked increase of prescribed potentially driving‐impairing medications (PDIMs), led by opioids, in driver autopsies. Drivers prescribed opioids are often not well advised on cognitive impairment. Pharmacists have a potential role to provide such advice, but their experiences and opinions are generally unreported.AimTo investigate the experiences, perceptions, and opinions of pharmacists dispensing prescribed opioids to patients, particularly what specific advice is given regarding driving safety, and to explore pharmacists' potential future role.MethodTen pharmacists in the regional city of Toowoomba, Queensland, consented to semi‐structured interviews, conducted between November 2019–November 2021. Interviews were then transcribed and subjected to reflexive thematic analysis to identify themes from the pharmacists' responses. This study is part of a broader project: How do doctors and pharmacists perceive their roles in ensuring safety in driving for both the patient and the general community? Ethical approval was granted by the Queensland University of Technology Research Ethics Committee (Reference no: 1900000374) and the study conforms to Australian National statement on ethical conduct in human research. Informed consent was obtained from all participants via completion of a written consent form after detailed project information was provided. This occurred at least 5 days after participants were first approached.ResultsThree main themes emerged: road safety versus freedom and independence, team approach and communication with general practitioners (GPs), and varying scope of advice on opioid impairment and tolerance. Pharmacists are aware of potential impacts on road safety, yet they are sympathetic towards the independence driving affords. GP communication and a team approach with GPs were the strongest subthemes. Pharmacists gave good information about cognitive impairment without specifically referencing driving. Pharmacists' learning about medications and driving occurred only “on the job.”ConclusionPharmacists' current advice to opioid‐medicated drivers (OMDs) would benefit from focused opioid upskilling empowering OMDs to make rational driving decisions. A more team‐oriented interaction, marked by better communication between pharmacists and GPs, should result in improved road safety among OMDs.
Why Do Talented People Leave? Assessing Talent Turnover Risks Using a Hybrid Approach
Authors: Estiri Mehrdad , Dahooie Jalil Heidary , Qorbani Ali Reza , Meidute‐Kavaliauskiene Ieva 
Published: December 2024

ABSTRACTAddressing the critical challenge of talent turnover in human resource management (HRM), the study aims to bridge the significant gaps in understanding the risks of talent turnover and the lack of robust frameworks for HR decision‐makers to assess and manage these risks effectively. Grounded in the resource‐based view (RBV), it introduces a hybrid methodology that synergizes failure mode and effects analysis (FMEA) with multi‐attribute decision‐making (MADM) methods using Z‐numbers. The research process involved an extensive literature review and expert panel discussions to curate an exhaustive list of turnover risks. These risks were appraised using FMEA technique and Z‐SWARA method. To validate the robustness of the evaluations, four different MADM methods were applied for risk ranking, which were then integrated using the BORDA count method. The framework's utility is exemplified by its application in a private bank in Iran, where it was used to identify and prioritize talent turnover risks. Findings reveals that skill underutilization, immigration, and underpayment are the most critical risks associated with talent turnover in our case, as confirmed by a sensitivity analysis. Practically, the framework equips HR managers with a robust tool for identifying and prioritizing talent turnover risks, facilitating strategic decision‐making in a uncertain business environment.
Functional and Nutritional Characterization of a Natural Diet Based on BIO102 Iron Biofortified Beans in Newly Weaned Mice
Authors: Jiménez‐Cardozo N. , Díaz‐Vesga Magda C. , Gallego‐Castillo Sonia , Álvarez Daniel , Orozco‐Agredo Juan Camilo , Ortega José Guillermo , Morales‐Jiménez Camilo 
Published: December 2024

ABSTRACTChildhood malnutrition persists as a critical issue in Latin America, particularly affecting protein and iron intake among children. Biofortification, enhancing crop nutritional content, offers a promising solution rooted in Latin American culinary traditions. This study describes the nutritional features of a natural diet based on iron biofortified red beans (BIO102) and examines its physiological impact in newly weaned Balb/C male mice over a 4‐week period. We evaluated weight gain, food intake, fasting blood glucose levels, and physical performance compared to control and regular maize diets. Results indicate that BIO102 and control diets show similar weight gain and food intake, with significant differences noted compared to the regular maize diet. BIO102 diet, characterized by reduced phytic acid content and increased in vitro iron bioaccessibility, significantly lowers fasting blood glucose levels by Week 4. Physical performance measures, encompassing aerobic endurance and limb strength, show no significant differences between BIO102 and control groups. Nutritional analysis highlights BIO102‐based diet's enriched protein content relative to regular maize. This study suggests that BIO102 could offer an alternative to address childhood nutritional deficiencies in Latin America through effective biofortification strategies, serving as a preliminary basis for future clinical investigations.
Magnetic Janus Particles: Synthesis and Multifunctional Applications
Authors: Tan Xuemei , Song Yuhang , Wan Chuchu , Huang Caili , Chai Yu , Yang Zhenzhong 
Published: December 2024

AbstractMagnetic Janus particles (MJPs) with compositional compartmentalization and strong magnetic responsiveness play a pivotal role in various application fields, such as biotechnology, medicine, and materials science. However, comprehensive reviews of the field of MJPs remain limited. Here, this article attempts to fill the gap by reviewing the current common synthetic strategies for MJPs, including masking, microfluidics, self‐assembly, phase separation, and seeded emulsion polymerization, among others. It then covers the multifunctional applications of MJPs, beneficial from their magnetic properties and anisotropic topological structure, primarily involving environmental remediation, biomedicine, smart displays, interfacial catalysis, emulsion stabilization, and structured liquid materials are presented, as well. Finally, the current challenges and future perspectives for MJPs are also discussed, aiming to fully harness the potential for broader applications.
The Influence of Length‐Diameter Ratio of Cellulose on Friction Characteristics of Screw Surface Investigated by EDEM Simulation
Authors: Yin Xuan , Zhang Dingyao , Li Liqi , Zhang Bing 
Published: December 2024

AbstractThis study integrates numerical simulations and tribological experiments using a plate‐on‐disc tribometer to examine the tribological behavior and wear mechanisms of cellulose materials in the solid transport screw of a parallel co‐rotating twin‐screw extruder. EDEM simulation results indicate that wear on the left screw primarily occurs on the screw threads while wear on the right screw is concentrated at the junction between the screw threads and the bottom of the screw groove. The meshing region experiences the most severe wear due to the combined effects of shear forces and contact stress. Tribological experiments with a plate‐on‐disc tribometer reveal that adding cellulose with higher aspect ratios reduces friction coefficients. When cellulose has a high aspect ratio, it improves the alignment of wear scar cracks and cellulose molecular chains on the friction contact surface. This results in a gradual alignment of rod‐shaped structural cellulose in the direction of frictional sliding, which reduces impact‐spalling wear, micro‐cutting wear, and scratching abrasion wear. Additionally, cellulose with higher aspect ratios can withstand higher rotational friction speeds during high‐speed friction, forming an orientation transfer layer on the friction contact surface. This enhances surface lubrication and reduces abrasive wear and adhesive wear.
Ictal SPECT Imaging Findings in Parkinson's Disease with Rapid Eye Movement Sleep Behavior Disorder
Authors: Groenewald Karolien , Warwick James , Dupont Patrick , Ackerman Jan‐Hendrik , Amsterdam Olivia , Carr Jonathan 
Published: December 2024

AbstractBackgroundRapid eye movement sleep behavior disorder (RBD) is an established prodrome and symptom of synucleinopathies. The pathophysiology of this disorder has been well studied but there is a lack of functional imaging data to illustrate the dysfunction in vivo.ObjectivesWe aimed to investigate the functional changes of RBD, by performing ictal REM sleep SPECT, comparing subjects with Parkinson's Disease (PD) and evidence of RBD to subjects with PD and no RBD.MethodsParticipants underwent a targeted clinical assessment, followed by video polysomnography (vPSG). Ictal 99mTc‐HMPAO SPECT was performed by injecting the tracer during vPSG confirmed REM sleep in seven cases (PD with RBD) and five controls (PD without RBD). Voxel‐wise, whole brain regional relative perfusion changes between both groups were assessed using statistical parametric mapping.ResultsNo difference in relative regional brain perfusion was demonstrated at a family wise error corrected p‐value of 0.05 between the case and control groups. At an uncorrected P‐value of <0.01, combined with a cluster extent threshold of 300 voxels, four clusters of increased perfusion were identified in the case group compared to the control group. The clusters were seen in the motor, somatosensory association, and prefrontal cortices. The reverse contrast did not show any significant clusters.ConclusionsIncreased perfusion of the motor cortex is in keeping with previous publications and motor phenomena seen in RBD. However, clusters included additional cortical regions. These findings demonstrate RBD as a wider sleep network dysfunction, rather than a manifestation of simple pontomedullary interruption.
Characteristics of four Blue Catfish fisheries with implications for harvest management
Authors: Neely Ben C. , Flores Ernesto , Johnson Craig M. , Koch Jeff D. , Miller Brett T. , Morrison Justin L. , Salazar Vanessa , Sprenkle Ely N. 
Published: December 2024

Abstract

Objective
Blue Catfish Ictalurus furcatus populations introduced into Kansas reservoirs in the past few decades have supported fisheries during the 21st century that have rapidly gained popularity among anglers. The increased importance of these fisheries has prompted questions about the status of populations, resilience to overfishing, and appropriate harvest management strategies. The primary objectives of this study were to quantify the dynamics of four Blue Catfish populations in Kansas impoundments, identify susceptibility to angler catch and harvest, and evaluate modeled population responses to harvest regulation.

Methods
We coupled capture–recapture efforts and a randomized sample design using low-frequency electrofishing to estimate population characteristics of the four Blue Catfish populations. We also estimated age and growth parameters from each population to characterize dynamic rate functions. Angler tag return data were summarized over a period of 1 year from each fishery to evaluate Blue Catfish susceptibility to angler catch and harvest. Finally, we consolidated these data into harvest regulation models to estimate the population response under varied harvest regimes.

Result
Estimated densities of stock-length (≥300 mm total length) Blue Catfish varied from 2.79 to 20.14 individuals/ha. Growth was variable, with individuals expected to reach quality length (≥510 mm total length) as early as age 4 and as late as age 9. The largest fish in each population were more vulnerable to angler capture, although harvest was low for all sizes of fish. Harvest regulation models indicated that populations were resilient to increased exploitation under all scenarios, with a limited risk of growth overfishing or recruitment overfishing.

Conclusion
Blue Catfish populations in Kansas reservoirs exhibit different dynamics but demonstrate resilience to overfishing. The largest individuals in populations are much more vulnerable to angler catch than smaller fish, but the risk of overharvest appears mitigated by angler self-regulation.
Does Flow of Remittances Matter for Enhancing the Labor Market Behavior of the Left‐Out Members? A Micro‐Level Analysis in the Context of Rural Jharkhand, India
Authors: Swain Suchi Smita , Das Gurudas , Paul Ujjwal Kanti 
Published: December 2024

ABSTRACTIn migration and remittance literature, considerable research has been conducted on how remittances impact the labor market behavior of family members left‐out in households with migrants. However, the influence of remittance inflow on these family members left‐out in households with migrants has been uninvestigated. This paper intends to bridge the gap by examining the influence of the flow of remittances on the labor market behavior of family members left‐out in households with migrants in Jharkhand (an Indian state), a major source area of out‐migration for economic reasons. Using cross‐sectional data from 575 households across six districts, we utilize the endogenous switching probit model to analyze the influence of the flow of remittances on the labor market behavior of family members left‐out in households with migrants. The study's findings suggest that (i) remittances exhibit a positive influence on the left‐out members' labor market behavior, and (ii) the likelihood of heads of regular groups engaging in the labor market is high compared to their counterparts in irregular groups. These insights suggest that the regularities in the flow of remittances instill financial confidence among the left‐out members, empowering them to invest in remunerative self‐employed activities, which in turn generates employment opportunities in the rural labor market.
Study on the interfacial bonding mechanism of nano‐injection molding PPS/PA6@Al: A molecular dynamics simulation study
Authors: Liu Donglei , Liu Suyun , Zhang Shaojian , Evsyukov S. A. , Luo Xin 
Published: December 2024

AbstractNano‐injection molding technology is widely used in producing lightweight and high‐strength composites. In this study, seven polymer‐metal interfacial models with inverted trapezoidal nano‐slots were constructed using the polymers polypropylene sulfide (PPS), polyamide 6 (PA6), and the metal aluminum (Al), where the formula ratio of PPS/PA6 is different. Molecular dynamics simulation was used to analyze the PPS/PA6 motion behavior and interfacial bonding mechanism during the nano‐injection molding process of the PPS/PA6 blend modification. The results indicated that the addition of strongly polarized PA6 to the inert material PPS could effectively enhance the interfacial bond strength of PPS/Al. Because the strong polar amide group in PA6 increased the force between the molecular chain and the metal surface, which led to more anchors forming between the interfaces, the number of anchors at the heterogeneous interfaces increased with the increase of PA6 content. In the interfacial damage simulations, adding PA6 enhanced the interfacial bonding energy, which required greater loading stresses to disengage the anchored molecular chains from the interface.Highlights
Strongly polarized amide groups in PA6 enhance the forces.
Addition of strongly polar PA6 gets higher interfacial energy and filling ratio.
Failure modes: Y‐shear and Z‐tensile.
Steaming soil is effective in eliminating invasive alien plants (IAPs) – part I: effect of exposure method
Authors: Bitarafan Zahra , Kaczmarek‐Derda Wiktoria , Berge Therese With , Øyri Carl Emil , Fløistad Inger Sundheim 
Published: December 2024

AbstractBACKGROUNDAs regulations on pesticides become more stringent, it is likely that there will be interest in steam as an alternative approach for soil disinfestation. This study investigates the feasibility of utilizing a soil steaming device for thermal control of invasive plants.RESULTSSeeds of Echinochloa crus‐galli, Impatiens glandulifera, Solidago canadensis, and rhizome fragments of Reynoutria × bohemica were examined for thermal sensitivity through two exposure methods: (1) steam treatment of propagative material in soil; (2) exposure of propagative material to warm soil just after heated by steam. Soil temperatures in the range of 60–99 °C and dwelling period of 3 min were tested. Increased soil temperature decreased seed germination/rhizome sprouting. The exposure method had a significant effect where higher temperatures were needed to reduce the seed germination/rhizome sprouting in method 2 explained by the effect of extra heat given in method 1. Using method 1, for E. crus‐galli and S. canadensis, the maximum mean temperature of approximately 80 °C was enough to achieve the effective weed control level (90%). This was lower for I. glandulifera and higher for R. × bohemica. Using method 2, 90% control was achieved at 95 °C for S. canadensis; more than 115 °C for I. glandulifera; and more than 130 °C for E. crus‐galli and R. × bohemica.CONCLUSIONOur findings showed a promising mortality rate for weeds propagative materials through soil steaming. However, the species showed varying responses to heat and therefore steam regulation should be based on the differences in weeds' susceptibility to heat. © 2024 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.