bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Potentials of a Maternal Mobile Wallet:&nbsp;a Qualitative Case Study on Opportunities and Challenges From Zimbabwe
Authors: Nyati-Jokomo Zibusiso , Dabengwa Israel Mbekezeli , Chikoko Laurine , Makacha Liberty , Nyapwere Newton , Makanga Prestige Tatenda 
Published: December 2020

Abstract
Background: There are no systems put in place regarding mobile money for maternal savings in Zimbabwe. Therefore, this paper aims to highlight: (a) existing strategies and experiences about maternal savings in Kwekwe District and, (b) examine the implications of household dynamics and current savings behaviour towards the feasibility of implementing the RoadMApp Maternal Healthcare Mobile Wallet (MHMW). Methods: Out of the 49 health facilities in Kwekwe, 2 hospitals (rural and urban), 4 rural health centres, 2 peri-urban, and 2 urban clinics were purposively selected for the study. Participants were recruited from these health facilities. 193 people took part in the study, through 11 Focus Group Discussions, 17 In-Depth Interviews, and 3 Community Meetings. The Socio-ecological Model’s categories are applied to interpret the results taking into consideration the barriers and enablers of maternal savings.Results: There is a paucity of information on strategies for maternal savings in Kwekwe District, Zimbabwe. The critical enabler for the implementation of an MHMW could be the use of existing community structures, like the burial societies and other savings clubs. Some of the essential barriers include low access to mobile phones, inadequate network coverage, power outages, a general lack of saving culture by communities, and the hyperinflationary environment in the country. Conclusion: Although, the socio-economic status of households may be the best predictor of maternal savings, ancillary factors such as financial literacy, educational level, cultural norms, and religion will help to understand the psychosocial reasons why communities engage in maternal savings. When implementing an MHMW, specific attention should be paid to individual and community/institutional level factors such as subsidies/interests on amounts saved, enforcing financial discipline, building local level mobile network infrastructure, and relying on locally available persons/systems.
Plant Exchange Networks and their Importance in Mbyá-Guarani Medicine in Southern Brazil
Authors: Andrade Julian Henrique Carlotto de , Rodrigues José , Benites André , Benites Cornélio , Acosta Arlindo , Benites Marcelina , Benites Cocelina , Gomes Ilda , Silva Jaime Valdir da , Antunes Eunice , Antunes Elisete , Martins José , Timóteo Daniel Martins , Franco Santiago , Morinico José Cirilo Pires , Silva Fernanda Ribeiro da , Hanazaki Natalia 
Published: December 2020

Abstract
Background: Experts in the Atlantic Forest, the Guarani people have the habit of transporting and exchanging plants due to their mobility throughout the territory. Historically, this habit contributed to the species composition and diversification among different phytophysiognomies that comprise the Atlantic Forest. Medicine and spirituality are traits that stand out within the Guarani culture, which is based on a holistic understanding of physical and spiritual well-being for the person’s health. To achieve this balance, they use a range of native and adapted plant species. Our goal is to understand some of the Guarani contributions to the cultural landscape in the Atlantic Forest. We also investigate whether kinship relations can facilite plant exchanges used in medicinal or mystical contexts between Guarani people. Methods: We conducted semi-structured interviews with key persons asking about the importance of forest environments for Guarani health and about visits to other Guarani villages and plants exchanged. Results: We visited seven Guarani Indigenous Territories in south Brazil, and with the participation of 12 respondents, we registered 27 species that were exchanged through different phytophysiognomies in the Atlantic Forest. These results show an intense movement of plants currently occurring between villages and the importance of these movements for both individual health and the integrity of the environments in which the Guarani villages are inserted. Conclusions: We observed a search for the recomposition of traditional species in the Guarani medical system, and we highlight the fundamental role of Guarani management in the conservation of the southern Atlantic Forest in indigenous territories.
Statistical Study of Medium-Scale Traveling Ionospheric Disturbances in Low-Latitude Ionosphere Using an Automatic Algorithm
Authors: Cheng PinHsuan , Lin Charles , Otsuka Yuichi , Liu Hanli , Rajesh Panthalingal Krishanunni , Chen Chia-Hung , Lin Jia-Ting 
Published: December 2020

Abstract
This study investigates the medium–scale traveling ionospheric disturbances (MSTIDs) statistically at the low–latitude equatorial ionization anomaly (EIA) region in the northern hemisphere. We apply the automatic detection algorithm including the three-dimensional fast Fourier transform (3-D FFT) and support vector machine (SVM) on total electron content (TEC) observations, derived from a network of ground-based global navigation satellite system (GNSS) receivers in Taiwan (14.5°N geomagnetic latitude; 32.5° inclination), to identify MSTID from other waves or irregularity features. The obtained results are analyzed statistically to examine the behavior of low-latitude MSTIDs. Statistical results indicate the following characteristics. First, the southward (equatorward) MSTIDs are observed almost every day during 0800-2100 LT in Spring and Winter. At midnight, southward MSTIDs are more discernible in Summer and majority of them are propagating from Japan to Taiwan. Second, northward (poleward) MSTIDs are more frequently detected during 1200-2100 LT in Spring and Summer with the secondary peak of occurrence between day of year (DOY) 100-140. The characteristics of the MSTIDs are interpreted with additional observations from radio occultation (RO) soundings of FORMOSAT-3/COSMIC as well as modeled atmospheric waves from the high–resolution Whole Atmosphere Community Climate Model (WACCM) suggesting that the nighttime MSTIDs in Summer is likely connected to the atmospheric gravity waves (AGWs).
Down-Regulation of miR-212-5p Facilitates Homocysteine-Induced Hepatocytes Apoptosis Via Targeting PSMD10
Authors: Zhang Huiping , Xiao Kun , Ma Shengchao , Xu Long , Ding Ning , Zhang Hui , Xie Lin , Xu Lingbo , Jiao Yun , Jiang Yideng 
Published: December 2020

Abstract
Background: Increasing evidences supported that elevated homocysteine (Hcy) levels contribute to cell apoptosis is implicated in the pathogenesis of liver injury, it correlates with liver disease severity. However, the underlying mechanism of apoptosis in Hcy-mediated liver injury remains obscure. Results: In this study, we found that homocysteine increases ER stress-mediated apoptosis and aggravates liver injury through up-regulation of PSMD10 expression in cbs+/- mice mice fed with high methionine diet and hepatocytes treated with homocysteine in vitro. Knockdown of PSMD10 expression remarkably reduced ER stress or apoptosis-associated protein in hepatocytes exposed to homocysteine. Moreover, bioinformatics analysis revealed that PSMD10 is a potential target gene of miR-212-5p, and luciferase reporter assay also confirmed that miR-212-5p negatively regulated PSMD10 expression by direct binding to its 3’-UTR regions. Subsequently, over-expression of miR-212-5p inhibited ER stress-mediated hepatocytes apoptosis though targeting PSMD10, all of which were abrogated by knockdown of miR-212-5p expression. Further study showed that the interaction between PSMD10 and GRP78 accelerated ER stress-mediated hepatic apoptosis induced by homocysteine. Conclusion: Taken together, these results demonstrated that down-regulation of miR-212-5p facilitates homocysteine-induced hepatocytes apoptosis via targeting PSMD10, which provides novel insight into the mechanism of homocysteine induced apoptosis in liver injury.
Clinico-Demographic Profile and Management Outcomes of Patients With Ocular Surface Squamous Neoplasia in a Tertiary Eye Care Hospital in Nepal
Authors: Shrestha Nisha , Sthapit Purnima Rajkarnikar , Saiju Rohit 
Published: December 2020

Abstract
Background: To evaluate the Clinico-demographic profile and management outcomes of patients with Ocular Surface Squamous Neoplasia (OSSN) in a tertiary eye care hospital in NepalMethods: All the patients with biopsy proven OSSN presenting to Oculoplasty and Ocular Oncology department of Tilganga Institute of Ophthalmology, Nepal over 1 year were retrospectively studied for clinical and demographic profiles, medical and surgical management and the outcomes of the management. Results: A total of 39 eyes of 37 patients were included in this study. The average age of patients was 44.56 years (range- 15 years to 84 years) consisting of 21(56.8%) male and 16 (43.2%) female. The ration of participating male and female patients (M:F) was 1.31:1. 35 cases (94.6%) were unilateral whereas 2 cases with Xeroderma pigmentosa had bilateral involvement. Nasal bulbar conjunctiva in (43.58%) was the most common. 6 (16.2%), 19 (51.4%) and 12 (32.4%) patients received primary medical management alone, surgical management alone and both surgical and adjuvant medical managements respectively.Histologically, the most common finding was CIN I with 10 (31.25%) patients. Surgical margins were free in 15 eyes (46.87%), whereas 17 eyes (53.12%) had one or more margins involved and hence, they received adjuvant topical chemotherapy. Moreover, 5 (15.38%) out of 39 eyes had recurrence.Conclusion: OSSN is usually present in middle age group though it may occur early and become rapidly progressive as in the cases of Xeroderma pigmentosa. Recurrence after surgery can occur despite optimal management.
The Application of Enhanced Recovery After Surgery and Negative-Pressure Wound Therapy in The Perioperative Period of Elderly Patients With Colorectal Cancer
Authors: Liu Hanrong , Yang Ping , Han Song , Zhang Yu , Zhu Hui-ying 
Published: December 2020

Abstract
Objective: To Explore the perioperative application of enhanced recovery after surgery (ERAS) and negative-pressure wound therapy in the elderly patients with colorectal cancer. Methods: A retrospective clinical data were studied in the patients with colorectal cancer in Department of General Surgery in Shanghai Forth People,s Hospital (from March, 2017 to March, 2019), One hundred and fifty patients with undergoing radical surgery for colorectal cancer were divided into two groups: ERAS group(n=76 cases, accepting ERAS management) and Conventional treatment(CT) group(n=74 cases, accepting traditional treatment),Bleeding in operation, the time of postoperative anal flatus ,number of wound dressing changing, time of wound healing, the length of postoperative hospital stay, readmission rate, postoperative complication, were compared between the two groups. Results: ERAS was associated with less bleeding in operation, less Wound fat liquefaction, less wound dressing changing, less time of wound healing，less time of postoperative anal flatus compare to CT group（P<0.05）; anastomotic fistula、readmission rate is similar in two groups（P>0.05）. Conclusion: The modified ERAS can be safely applied to the perioperative period of elderly colorectal cancer patients and promote recovery; negative-pressure wound therapy is helpful for wound healing and promoting rehabilitation.
The Effect of Benson's Relaxation Technique on Occupational Stress Among Nurses Caring for Covid-19 Patients in Sabzevar, Iran
Authors: Borzoee Fateme , Quchan Arezoo Davarinia Motlagh , Tabrizi Zohre Mohammadzade , Rastaghi Sedighe , Hesari Mohammad Hosseinzade , Heshmatifar Narjes 
Published: December 2020

Abstract
Background: Today, nurses face with caring for Covid-19 patients, consider as a new occupational stressor in the nursing profession.Primary Study Objective: To investigate the effect of Benson's relaxation technique (BRT) on occupational stress of nurses exposed to Covid-19 patients.Methods/Design: The present study is a two-group clinical trial with parallel design.Setting: The samples were and randomly allocated into BRT and control groups based on the inclusion and exclusion criteria.Participants: 70 nurses working in the intensive care unit (ICU) in the Covid-19 treatment center in Sabzevar, IranIntervention: Intervention group were performed the BRT exercises twice a day for 1 month during 20 minutes each time. The data was collection through Osipow Occupational Stress Questionnaire. Primary Outcome Measures: Occupational stressResults: The mean occupational stress score in the BRT group immediately and after 1 week of intervention, was significantly lower than the control group (P = 0.001). The repeated measure analysis of variances test showed a significant difference in the mean occupational stress score in the 6 subscales after the intervention between the two groups (P < 0.05).Conclusion: This study showed BRT reduces occupational stress among nurses working in the ICU, caring for Covid-19 patients.Trial registration: IRCT, IRCT20131113015393N6. Registered 30 March 2020, https://en.irct.ir/trial/46609
Comprehensive Profiling and Characterization of The Absorbed Components and Metabolites in Mice Serum and Tissues Following Oral Administration of Qingfei Paidu Decoction by UHPLC-Q-Exactive-Orbitrap HRMS
Authors: Liu Wei , Huang Jian , Zhang Feng , Zhang Congcong , Li Rongsheng , Wang Yongli , Wang Chaoran , Liang Xinmiao , Zhang Weidong , Yang Ling , Liu Ping , Ge Guang-Bo 
Published: December 2020

Abstract
Background: Qingfei Paidu decoction (QFPDD) is a Chinese medicine compound formula recommended for combating corona virus disease 2019 (COVID-19) by National Health Commission of the People's Republic of China. This study aims to identify the main constituents in QFPDD and the absorbed components (including prototypes and metabolites) in serum and tissues after oral administration of QFPDD to mice.Methods: A practical and sensitive method of UHPLC-Q-Exactive-Orbitrap HRMS was developed to identify the chemical constituents in QFPDD and the absorbed prototypes as well as the metabolites in mice serum and tissues following oral administration of QFPDD.Results: A total of 405 chemicals, including 40 kinds of alkaloids, 162 kinds of flavonoids, 44 kinds of organic acids, 71 kinds of triterpene saponins and 88 kinds of other compounds in the water extract of QFPDD were tentatively identified via comparison with the retention times and MS/MS spectra of the standards or refereed by literature. With the help of the standards and in vitro metabolites, 195 chemical components (including 104 prototypes and 91 metabolites) were identified in mice serum after oral administration of QFPDD. In addition, 165, 177, 112, 120, 44, 53 constituents were identified in the lung, liver, heart, kidney, brain, and spleen of QFPDD-treated mice, respectively.Conclusions: An UHPLC-Q-Orbitrap HRMS based method was established for chemical profiling the constituents in QFPDD, while the absorbed prototypes and metabolites occurring in mice serum and tissues were investigated following oral administration of QFPDD. These findings provided key information and guidance for further investigation on the pharmacologically active substances and clinical applications of QFPDD.
Ocimum Sanctum Ameliorates Valproic Acid – Induced Hepatotoxicity
Authors: Iqbal Muhammad Omer , Rahim Qurratulain , Khan Hania Mehboob , Akhter Imran , Naeem Faiza , Ahmad Fiaz ud din 
Published: December 2020

Abstract
OBJECTIVE: Evaluation of hepatoprotective potentials of Ocimum sanctum against Valproic-acid-induced-hepatotoxicity in Wistar-albino-rats. METHOD: 70% of ethanolic extract of Ocimum sanctum was prepared under reduced pressure of rotary evaporator. Wistar albino rats were used as the experimental model and rats were divided into four groups (six animals each). The normal group received normal saline and group 2, 3 and 4 was injected valproic acid (500mg/kg) for four consecutive days respectively. Group 1 and 2 received normal saline throughout the period of study about 21 days while group 3 and 4 received different doses of extract of OS i.e. 200mg/kg and 300mg/kg. Through retro-orbital blood samples were collected on alternative days such as 0,7,21. By using one-way ANOVA, data was analyzed. Hepatotoxicity induced by valproic acid at the dosage of (500mg/kg) resulted in significant elevation in weight of animals and serum hepatic enzymes level of ALAT, ASAT, ALP and increase in the serum bilirubin. RESULTS: OS at different doses (200mg/kg and 300mg/kg) considered statistically significant (p ≤ 0.05) against all parameters. OS cause a significant reduction in weight of animals and serum enzymes biomarkers i.e. (ALAT, ASAT and ALP) including bilirubin content. OS may prove its hepatoprotective activity by increase a significant level of protein albumin. CONCLUSION: antioxidant activity of OS and secondary metabolites such as flavonoids depicts hepatoprotective nature against valproic-acid-induced-hepatotoxicity.
Comparative Evaluation of Korean White Ginseng and Red Ginseng Efficacies in a Mouse Model of Ischemia/Reperfusion-Induced Stroke
Authors: Jin Myungho , Kim Kyung-Min , Lim Chiyeon , Cho Suin , Kim Young Kyun 
Published: December 2020

Abstract
Background: Stroke is a condition characterized by brain tissue damage owing to a decrease in the brain's oxygen supply due to blocked blood vessels, and 80% of all strokes are classified as cerebral infarction. Notably, the incidence rate tends to increase with increasing age. In this study, we compared the efficacy of white ginseng (WG) and red ginseng (RG) extracts (WGex and RGex, respectively) in an ischemic stroke mouse model and confirmed the underlying mechanisms of action.Methods: Mice were orally administered WGex or RGex 1 h before performing middle cerebral artery occlusion (MCAO) for 2 h; the size of the infarct area was measured 24 h after MCAO. The neurological deficit score was evaluated, the efficacy of the two drugs was compared, and the mechanism of action was confirmed using methods such as tissue staining and protein quantification.Results: In the MCAO-induced ischemic stroke mouse model, WGex and RGex showed neuroprotective effects in the cortical region, with RGex demonstrating a generally stronger efficacy than WGex. Furthermore, it was confirmed that ginsenoside Rg1, a representative indicator substance, was not involved in mediating the effects of WGex and RGex.Conclusion: WGex and RGex inhibited brain injury attributed to ischemia/reperfusion, with RGex revealing a more potent effect. At 1,000 mg/kg body weight, only RGex reduced cerebral infarction and edema, and both anti-inflammatory and anti-apoptotic pathways were involved in mediating these effects.
The Interaction of the Oxytocin Receptor Gene and Subtypes of Child Abuse on Social Cognition in Euthymic Patients With Bipolar Disorder Type I
Authors: Rios Ulises , Moran Javier , Hermosilla Jimena , Gonzalez Rene , Muñoz Paulina , Herrera Luisa , Moya Pablo R , Jimenez Juan Pablo 
Published: December 2020

Abstract
Background: Most studies on cognitive impairment in Bipolar Disorder (BD) have neglected the role of early stress, despite the high frequency of childhood maltreatment in this clinical group. The aim of this study was to establish a connection between a history of emotional, physical, and sexual abuse in childhood and social cognition (SC) functioning in patients with BD type I in euthymia, and to test a possible moderating effect of the polymorphism rs53576 in the oxytocin receptor (OXTR) gene. Results: We found a high frequency of child abuse, indicating that BD patients who had been victims of physical and emotional abuse as children, and were carriers of the GG genotype at OXTR rs53576, displayed higher social cognition alterations, specifically in an emotion recognition test. Conclusions: The gene-environment interaction study presented here proposes a Differential Susceptibility model of a genetic polymorphism that can be plausibly associated with SC functioning. This evidence might help to identify at-risk clinical subgroups within a diagnostic category with well-established intra-group heterogeneity such as BD. Future research aimed at testing the inter-level impact of early stress constitutes an ethical-clinical duty in light of the high rates of childhood abuse reported in bipolar patients.
Knowledge and Attitude Towards Preconception Care and Associated Factors Among Health Care Providers in North Wollo Zone, Amhara Region, Ethiopia, 2020
Authors: Belay Teketay Debalkie , Alemayehu Mulunesh , Mekonen Nakachew , Tegegne Tesfaye Birhane 
Published: December 2020

Abstract
Introduction: preconception care is provision of biomedical, behavioral, and social health interventions to reproductive age women and their partners before pregnancy to improve maternal and child health. Its package was developed in 2012. Preconception care not well studied in Ethiopia particularly in the study area. Objective: The aimed to assess the level of knowledge and attitude towards preconception care and associated factors among healthcare providers in North Wollo Zone, 2020. Methods: institution based cross sectional study on 536 health care providers was conducted. Multi stage sampling technique was used. Simple random sampling technique was employed to select the health institutions and study participants. Data were collected; structured, pre tested and self-administered questionnaire. Binary logistic regression used to compute descriptive statistics. P-value < 0.05%, OR with 95% CI used for presence and strength of significant association. Result: This study revealed that 49.1% and 44.2% of health care providers had good knowledge and favorable attitude towards preconception care, respectively. Variables; higher monthly salary [AOR 1.9: 95% CI: 1.1-3.2)], midwifery as profession [AOR: 2.1(95% CI: 1.1-3.7)], library in the institution [AOR: 2.6 (95% CI: 1.2-5.8)], ever heard about preconception care [AOR: 5.6 (95% CI: 3.0 - 10.4)] on knowledge and degree & above educational status [(AOR: 2.1 (95% CI: 1.4-3.1)], good knowledge [AOR: 2.3 (95% CI: 1.3-3.3)] and ever read guideline [AOR: 2.0 (95% CI: 1.2-3.3)] on favorable attitude of preconception care were significantly associated factors respectivelyConclusion and recommendation: nearly half of the participants had poor knowledge and unfavorable attitude on preconception care due to mentioned factors and can be averted by making the institutions to have library, health care providers should to read about preconception care.