bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of the Phytochemical Compounds like Modulators in Gut Microbiota and Oxidative Stress
Authors: Martínez Yordan , Más Dairon , Betancur Cesar , Gebeyew Kefyalew , Adebowale Tolulope , Hussain Tarique , Lan Wensheng , Ding Xinghua 
Published: May 2020

Background:Currently, daily consumption of green herb functional food or medicinal herbs has increased as adopted by many people worldwide as a way of life or even as an alternative to the use of synthetic medicines. Phytochemicals, which are a series of compounds of relatively complex structures and restricted distribution in plants, usually perform the defensive functions for plants against insects, bacteria, fungi or other pathogenic factors. A series of studies have found their effectiveness in the treatment or prevention of systemic diseases such as autoimmune diseases, cancer, neurodegenerative diseases, Crohn's disease and so on.Objective:This review systematizes the literature on the mechanisms of the phytochemicals that react against unique free radicals and prevent the oxidative stress and also summarizes their role in gut microbiota inhibiting bacterial translocation and damage to the intestinal barrier and improving the intestinal membrane condition.Conclusion:The gut microbiota modulation and antioxidant activities of the phytochemicals shall be emphasized on the research of the active principles of the phytochemicals.
Evaluating Lean Liver Volume as a Potential Scaler for In Vitro-In Vivo Extrapolation of Drug Clearance in Obesity Using the Model Drug Antipyrine
Authors: Sinha Jaydeep , Duffull Stephen B. , Green Bruce , Al-Sallami Hesham S. 
Published: May 2020

Background:
In vitro-in vivo extrapolation (IVIVE) of hepatic drug clearance (CL) involves the scaling of
hepatic intrinsic clearance (CLint,uH) by functional liver size, which is approximated by total liver volume (LV) as
per the convention. However, in most overweight and obese patients, LV includes abnormal liver fat, which is not
thought to contribute to drug elimination, thus overestimating drug CL. Therefore, lean liver volume (LLV) might be
a more appropriate scaler of CLint,uH.

Objective:
The objective of this work was to assess the application of LLV in CL extrapolation in overweight and
obese patients (BMI>25 kg/m2) using a model drug antipyrine.

Methods:
Recently, a model to predict LLV from patient sex, weight, and height was developed and evaluated. In
order to assess the LLV model’s use in IVIVE, a correlation-based analysis was conducted using antipyrine as an
example drug.

Results:
In the overweight group (BMI >25 kg/m2), LLV could describe 36% of the variation in antipyrine CL
(R2 = 0.36), which was >2-fold higher than that was explained by LV (R2 = 0.17). In the normal-weight group
(BMI ≤25 kg/m2), the coefficients of determination were 58% (R2 = 0.58) and 43% (R2= 0.43) for LLV and LV,
respectively.

Conclusion:
The analysis indicates that LLV is potentially a more appropriate descriptor of functional liver size than
LV, particularly in overweight individuals. Therefore, LLV has a potential application in IVIVE of CL in obesity.
Anxiety and Osteoarthritis Disability: Updated Overview and Commentary
Authors: Marks Ray 
Published: May 2020

Introduction:Osteoarthritis, a widespread highly painful often incapacitating joint disease continues to impose immense personal and societal challenges among adults of all ages, especially among older adults. In the absence of any effective cure or treatment, it has become essential to explore all correlates of this chronic disabling disease, especially those that might be preventable or modifiable. Anxiety, a potentially remediable state of mental distress - found linked to chronically disabling forms of arthritis, in various imperceptible ways, and which may have an immense bearing on the outcomes of osteoarthritis, has not received as much attention in the related literature as other topics, such as surgery.Objective:In line with previous promising work, this narrative review elected to explore the extent to which current researchers in the field are pursuing this topic, and if so, the degree to which prevailing peer-reviewed data sources support an important role for continued research in this realm, and in what regard.Methods:Primarily explored were the key databases housing relevant publications that emerged over Aug 1, 2018-Feb 26, 2020 using the keywordsOsteoarthritisandAnxiety.Using a descriptive approach, the relative progress made over the past five previous years in this regard was assessed, in addition to what joints have been studied and with what frequency, and how the degree of interest compares to other currently researched osteoarthritis themes. The potential for intervening in the osteoarthritis pain cycle by addressing anxiety was also examined.Results:Findings show a high level of current interest in this topic, and that despite the paucity of prospective studies, studies on joints other than the knee and hip joints, some equivocal conclusions, small numbers of anxiety-related studies compared to other topics, and substantive design limitations, it appears that future research in this realm is strongly indicated.Conclusion:This topic if examined further is likely to produce highly advantageous results at all stages of the osteoarthritic disease process and in the context of primary, secondary, as well as tertiary measures to ameliorate osteoarthritis pain and disability.
The Impact of Royal Jelly against Hepatic Ischemia/Reperfusion-Induced Hepatocyte Damage in Rats: The Role of Cytoglobin, Nrf-2/HO-1/COX-4, and P38-MAPK/NF-κB-p65/TNF-α Signaling Pathways
Authors: Ali Fares E.M. , Saad Eldien Heba M. , Mostafa Nashwa A.M. , Almaeen Abdulrahman H. , Marzouk Mohamed R.A. , Eid Khalid M. , Ghoziz Ahmed H.E. , Ebrahiem Abdelaziz F. , Hagag Mohamed G. , Ghogar Osama M. 
Published: May 2020

Objective:
The present study was conducted to elucidate the underlying molecular mechanism as well as the potential hepatoprotective effects of royal jelly (RJ) against hepatic ischemia/reperfusion (IR) injury.

Methods:
Rats were assigned into four groups; sham (received vehicle), IR (30 minutes ischemia and 45 minutes reperfusion), sham
pretreated with RJ (200 mg/kg P.O.), and IR pretreated with RJ (200 mg/kg P.O.). The experiment has lasted for 28 days.

Results:
Hepatic IR significantly induced hepatic dysfunctions, as manifested by elevation of serum transaminases, ALP and LDH
levels. Moreover, hepatic IR caused a significant up-regulation of P38-MAPK, NF-κB-p65, TNF-α and MDA levels along with
marked down-regulation of Nrf-2, HO-1, COX-4, cytoglobin, IκBa, IL-10, GSH, GST and SOD levels. Additionally, marked histopathological changes were observed after hepatic IR injury. On the contrary, pretreatment with RJ significantly improved hepatic
functions along with the alleviation of histopathological changes. Moreover, RJ restored oxidant/antioxidant balance as well as hepatic expressions of Nrf-2, HO-1, COX-4, and cytoglobin. Simultaneously, RJ significantly mitigated the inflammatory response by
down-regulation of P38-MAPK, NF-κB-p65, TNF-α expression.

Conclusion:
The present results revealed that RJ has successfully protected the liver against hepatic IR injury through modulation of
cytoglobin, Nrf-2/HO-1/COX-4, and P38-MAPK/NF-κB-p65/TNF-α signaling pathways.
Una experiencia educativa transmedia
Authors: Zorrilla Abascal María Luisa 
Published: May 2020

En el video, la doctora Zorrilla de la Universidad Autónoma de Morelos, en México, comenta el concepto de narrativa transmedia y presenta una investigación-intervención desarrollada en una escuela morelense donde los estudiantes abordaron una novela en tres soportes diferentes. Incluye testimonios de alumnos y comparte, a través de un sitio web, recursos adicionales sobre el tema. Video disponible: https://youtu.be/kuWU8uDUbuc
REFLEXÃO TEOLÓGICO-PASTORAL A PARTIR DO DECRETO AD GENTES
Authors: Almeida Nadi Maria de , Dunne Victor 
Published: May 2020

Este artigo se propõe a uma análise do documento do Concílio Vaticano II sobre a atividade missionária, o Decreto Ad Gentes. Objetiva ponderar os fundamentos, horizontes e propostas missionárias a partir de uma reflexão teológica e pastoral do Decreto, assinalando a relevância do documento para a missão da Igreja no mundo contemporâneo. O estudo teve uma abordagem exploratória, qualitativo do Decreto Ad Gentes, auxiliada por pesquisas bibliográficas de autores que investigaram e escreveram sobre o assunto. O texto trás primeiro uma análise do documento, apresenta o contexto em que o mesmo surgiu; o processo da redação e a estrutura do texto e mostra o longo processo da redação até que chegassem a um consenso e a aprovação do seu conteúdo, com unanimidade de votos. Proporciona, ainda, uma síntese dos pontos principais do conteúdo de cada capítulo, bem como sua divisão textual. O segundo momento traz a fundamentação bíblico-teológico do texto com seus novos horizontes e propostas missionárias ad gentes enquanto processo de evangelização, tal como aparece no Decreto. A pesquisa deseja revigorar o apelo a um maior engajamento nas atividades missionárias da Igreja, mostrar a importância da missão e estimular um compromisso pastoral mais aberto e missionário no mundo contemporâneo.
A CRISTOLOGIA DE ANTONIO MANZATTO (revelação, antropologia e literatura)
Authors: Bingemer Maria Clara Lucchetti 
Published: May 2020

Antonio Manzatto é pioneiro em muitas coisas. Talvez uma das mais importantes seja a iniciação do leitor brasileiro no diálogo entre teologia e literatura. Sua tese doutoral sobre a obra de Jorge Amado lida a partir da teologia é um marco na caminhada teopoética e teoliterária do país e do continente.Neste artigo tentaremos considerar a obra de Manzatto a partir de um ponto de vista: a cristologia. Área maior da teologia cristã, é algo que não pode não estar presente quando se trata de analisar e comentar a obra de alguém que é antes de mais nada teólogo e assumido como tal.
Lateral rhinotomy and coblation for treatment of a nasal hamartoma in a dog
Authors: Prudic Rochelle A. , Wallace Mandy L. , Bartges Joseph W. , McLear Patrick W. , Dickerson Vanna M. , Perez-Ramirez Guillermo 
Published: May 2020

Abstract

CASE DESCRIPTION
A 4-year-old spayed female French Bulldog was referred for treatment of a suspected right-sided nasal angiofibroma associated with a 4-month history of unilateral nasal discharge and stertor.

CLINICAL FINDINGS
The dog appeared healthy other than right-sided mucoid debris and decreased airflow through the right naris. The dog was anesthetized, and a large intranasal mass was observed obstructing the right nasal passage and abutting the nasal septum.

TREATMENT AND OUTCOME
A lateral rhinotomy was performed, and rigid endoscopes (0° and 30°) were used to examine the right nasal cavity. The mass filled the anterior aspect of the nasal cavity and involved a portion of the nasal turbinates with some erosion. A coblation unit was used to ablate tumor tissue laterally to remove the tumor in piecemeal fashion. Recovery was routine with only minor epistaxis after surgery, and the dog was discharged the next day. Eight months after surgery, follow-up CT revealed right-sided nasal turbinate and conchal atrophy consistent with prior mass ablation. No macroscopic recurrence was detected, and the owners reported only rare, clear rhinorrhea.

CLINICAL RELEVANCE
Findings suggested that coblation may be an alternative to radiation therapy for vascular tumors with minimal invasion and low metastatic potential.
EARLY TRACES HINDU-BUDDHIST INFLUENCE ALONG THE NORTH COAST OF CENTRAL JAVA: ARCHAEOLOGICAL SURVEY OF THE DISTRICT OF BATANG
Authors: Indradjaja Agustijanto , Degroot Véronique 
Published: May 2020

Abstrak. Jejak awal Pengaruh Hindu-Buddha di Sepanjang Pantai Utara Jawa Tengah: Survei Arkeologi di Kota Batang. Penelitian arkeologi di pantai utara Jawa Tengah mengenai kehidupanmasa Hindu-Buddha hampir selalu dipusatkan pada wilayah antara Kedu-Yogyakarta, yang dikuasaioleh Kerajaan Matāram pada sekitar abad ke-8–9 Masehi. Penelitian yang berupaya mempelajaridan merekonstruksi kondisi sosial masyarakat di daerah pesisir masa pra-Matāram selama ini belumpernah dilakukan. Karya tulis ini berusaha melakukan eksplorasi pada masa pra-Matāram di JawaTengah, khususnya di Kabupaten Batang yang diduga sebagai salah satu daerah yang penting padaawal periode sebelum munculnya Kerajaan Matāram di pedalaman Jawa Tengah. Pengumpulan datadilakukan melalui survei, selanjutnya data arkeologi yang relevan dilakukan analisis deksriptif untukmenjawab pertanyaan di dalam penelitian. Hasil survei berhasil mengidentifikasikan sejumlah temuanpenting seperti arca, candi dan prasasti mulai dari wilayah pesisir sampai pedalamanan KabupatenBatang. Berdasarkan identifikasi sejumlah temuan arkeologi tersebut tampak bahwa wilayah Batangsudah mendapat pengaruh Hindu-Buddha jauh sebelum munculnya Kerajaan Matāram kuna sekitarabad ke-8 M. Abstract In Coastal Central Java, archaeological research dealing with the Hindu-Buddhist periodis almost always focused on the coastal area between Kedu and Yogyakarta, which was controlledby the Matāram Kingdom around the 8-9th Century AD. Research that attempts to investigate andreconstruct the social conditions of coastal communities during the pre-Matāram period has yetto be undertaken. This paper is such an attempt. It explores Hindu-Buddhist remains in the BatangDistrict, a district which, we believe, was an important entry point for Hindu-Buddhist traditionsprior to the emergence of the Matāram Kingdom in the hinterland of Central Java. Data collectedthrough the survey, further archaeological data relevant will be conducted descriptive analysis toanswer questions in the study. The survey results have identified a number of important findingssuch as statues, temples and inscriptions ranging from coastal areas to inland Batang. Based onthe identification of a number of archaeological findings it apparent that the area in Batang alreadyappear influence of Hindu-Buddhist long before the emergence of the ancient Matāram Kingdomaround the 8th Century AD.
PENGARUH PERGERAKAN MEANDER TERHADAP KESEIMBANGAN ALUR SUNGAI
Authors: Murniningsih Siti 
Published: May 2020

Most of the river in Indonesia has a meander area especially located at the lower reach. Since the pattern of the community behaviour in Indonesia, people live in surrounding or along the river while the river plains and delta consist of alluvial soils, thus, meander migration usually occurs as a response to natural or manmade disturbances of the fluvial system. Meander River in urban area usually encourage sediment transport problem such as riverbed aggradations at the area surrounding inside of the bank then will decrease the river capacity in retaining flood while simultaneously eroding on the outer banks of meander bends. Regarding velocity distribution at the channel cross section, the minimum velocity is occurring on the inside of the meander, therefore some of the sediment loads is deposited. Related with the phenomena, protection against sedimentation and erosion along meandering river extremely needed. Previously, river adjustment within meander area are continually being made, therefore, eventually the gradient of a stream is altered to accommodate the volume of water and the velocity necessary to transport the sediment load. In this paper,understanding of various phenomenon’s in the meander area due to the sedimentation processes are described and propose the new concept of protection with low impact development (LID) approach.
PENYEMPURNAAN SISTEM PENGELOLAAN AIR IRIGASI MENGHADAPI IRIGASI MODERN DI INDONESIA
Authors: Soekrasno Soekrasno 
Published: May 2020

Damage to irrigation areas in Indonesia covering an area of 0.37 million hectares for severe damage and an area of 1.25 million hectares for moderate and mild damage, has an impact on Indonesia's ability in rice production; rice imports were almost half a century, and only the adequacy of rice was 2 X, i.e. 1984 and 2009. This was due to low irrigation services which resulted in less optimal carrying capacity of food security. The deterioration in the function of irrigation services can be grouped into 5 causes of low irrigation pillars, namely: vulnerability of water sources, lack of irrigation infrastructure, low irrigationwater management, weak management institutions, and low human resources. The cause will be eliminated by the irrigation modernization program by working on these five pillars. One of the pillars in the modernization of irrigation that needs to be improved is the irrigation management system. The purpose ofthis paper is to contribute ideas in improving the irrigation management system in Indonesia. The author has conducted observations and research on several irrigation areas, both the authority of the Central, Provincial and District Governments, especially visits to DI Wadaslintang, Central Java and DI Bondoyudo, East Java concerning irrigation water management systems. What stands out is the low level of irrigation services due to the inefficient irrigation water management system in Indonesia, in addition to the nature of service-based provision and not service-oriented based on farmers' needs. Identification wascarried out on the DI to find out the reasons for the low irrigation water management system, namely: orientation to water supply, calculation of irrigation requirements, water allocation method, irrigationwater distribution schedule, irrigation water loss, irrigation operational steps, irrigation water productivity measurement This study analyzes the factors causing the low irrigation water management system while making a formula for the improvement proposal in the form of 7 steps.
ANALISA PENURUNAN RAFT-PILED FOUNDATIONAREA BOGIE WAREHOUSE PROYEK JAKARTA LRT SECTION DEPOT
Authors: Wijaya Amelia , Kawanda Aksan 
Published: May 2020

The foundation of the raft post is the bottom structure of a building that channeled the load from the structure over the soil under it. Carrying capacity of drill pile foundation is influenced by the capacity of the pole tipand bearing capacity of the pole blanket. The decline in this area can be an immediate decline and a decrease in consolidation. This study aims to analyze the decrease of raft poles and the proportion of load bearing in the bogie area of the Kelapa Gading LRT warehouse depot - Jakarta. From the analysis of theNSPT test results in the field, the ultimate carrying capacity and the decrease that occurred on the raft poles were obtained. Based on the results of calculation of the ultimate carrying capacity of a single drill pole of 1.1 x 104 kN and the carrying capacity of the group is 1.1 x 108 kN. Calculation of group efficiency with the Feld method is obtained at a value of 0.588. In the calculation of the immediate decline of the pole, a value of 5 cm is obtained and a decrease in consolidation of 7 cm. From the calculation of the proportion of raft poleload bearing the value of Pr = 6 x 10-6 is obtained, which means that load bearing can be said to be dominated by rafts.
EVALUASI FAKTOR TEKNIS PENENTU KRITERIA DRAINASE BERWAWASAN LINGKUNGAN
Authors: Andajani Sih , Hidayat Dina P.A 
Published: May 2020

Integrated management of water resources is something that must be done to ensure the sustainability of water resources. Based on Minister of Public Works Regulation No. 10 of 2015, water resources management in Indonesia is based on 5 pillars where one of the pillars is the conservation of waterresources. Conservation of water resources is a basic concept of ecodrain wherein rainwater falling as much as possible will be absorbed into the ground again or known as zero runoff. One of the technical factors thatdetermine environmentally sound drainage criteria is the recharge system. In this research, the influence of the application of bioretension and rain garden will be discussed as one of the absorption systems for runoff hydrographs in an area, in this case the Upper Cisadane Watershed is used as the research location. Based on the results of the study, it was obtained the reduction of peak flood discharge with the application of type I, II, III and IV biorescence to the existing peak flood discharge of 26.89-26.93%, and reduction of peak flood discharge with the application of rain garden of 27.73%.
Pendekatan Model Wasp Pada Pengendalian Pencemaran Sungai Dengan Parameter Uji Cod
Authors: Saily Randhi , Fauzi Manyuk , Suprayogi Imam 
Published: May 2020

The rapid development requires enormous natural resources. So it appears that in development there is an overuse of natural resources, which results in disruption of the water system balance. Various impacts will occur as a result of unbalanced use of natural resources, the use of unbalanced natural resources around the Siak river area, causing an increase in pollution entering the river. Regulation of the Minister of PUPR Number 4 of 2015 concerning Criteria and Designation of River Areas, Siak River is one of the major rivers that receive national attention and is also included in the national strategic river category. Control of river pollution is done by analyzing the WASP modeling and the existing condition of the Siak river, the effect of the levels on the parameters of the mainstay discharge and the mainstay discharge and the percentage of pollution load reduction carried out to meet the class II quality standards. The results showed that theoverall condition of the Siak river was polluted. The average excess capacity of the COD pollution load at the time of the depandable discharge is -454,516 kg/day. Then at the time of the depandable discharge isvalued at -181,087 kg/day. The control effort taken is to reduce the COD contamination load so that the capacity of the pollution load is +177,742 kg/day when the depandable discharge is maximum and +72,536kg/day when the depandable discharge is minimum. Percentage reduction of COD contamination load at the minimum and maximum depandable discharge to meet the class II quality standard of 50%.
Reduksi Emisi Gas Rumah Kaca Campuran Aspal Industri Konstruksi Jalan
Authors: Purboyo Wiryawan , Maha Indra 
Published: May 2020

The construction industry plays an important role in the national economic development, however it also contributes to greenhouse gas (GHG) emitters. According to the BPS Indonesia regarding Final Energy Consumption referring to the 2009-2013 sector, the Industrial and Construction sector ranked first, thus the phenomenons of global warming, climate change, energy conservation and GHG emission reduction has become important issues in the construction industry including road contruction industry. This study is to determine the amount of GHG emissions from road construction industry at the production and the implementation of the asphalt pavement construction stages and also to determine the gap of mitigation results against the GHG emission benchmarks. To achieve these objectives, development of data activities and identification of key sources of GHG emissions for each stage are carried out. Equipment type, capacity,specifications, year of manufacture and fuel requirements were obtained from the survey. GHG emission estimates refer to the IPCC 2006 procedures and Bina Marga AHSP 2010. Aggregate heating at the production stage of HMA using diesel as a benchmark compared to aggregate heating: 1. HMA production using LPG 2. HMA production with 60% original aggregate + 40% RAP using Solar 3. HMA production with 60% original aggregate + 40% of RAP uses LPG 4. Production of warm asphalt mixture (WMA) uses Solar 5. Production of warm asphalt mixture (WMA) uses LPG. Furthermore, the study also carried out a reduction in the temperature of the asphalt mixture to the distance and travel time from the production location to the project location. achieved reduction of GHG emissions exceeding the target of 2.4%. Themost dominant aggregate heating process produces GHG emissions of 59.5% - 67.5% for all stages. Ranking of the largest emitters: AMP (aggregate heating.