bluuebunny/crossref_metadata_2025_split huggingface dataset:
Entirely innocent: a historical sociopragmatic analysis of maximizers in theOld Bailey Corpus
Authors: CLARIDGE CLAUDIA , JONSSON EWA , KYTÖ MERJA 
Published: December 2019

Based on an investigation of theOld Bailey Corpus, this article explores the development and usage patterns of maximizers in Late Modern English (LModE). The maximizers to be considered for inclusion in the study are based on the lists provided in Quirket al.(1985) and Huddleston & Pullum (2002). The aims of the study were to (i) document the frequency development of maximizers, (ii) investigate the sociolinguistic embedding of maximizers usage (gender, class) and (iii) analyze the sociopragmatics of maximizers based on the speakers’ roles, such as judge or witness, in the courtroom.Of the eleven maximizer types focused on in the investigation,perfectlyandentirelywere found to dominate in frequency. The whole group was found to rise over the period 1720 to 1913. In terms of gender, social class and speaker roles, there was variation in the use of maximizers across the different speaker groups. Prominently, defendants, but also judges and lawyers, maximized more than witnesses and victims; further, male speakers and higher-ranking speakers used more maximizers. The results were interpreted taking into account the courtroom context and its dialogue dynamics.
Design and fabrication of a novel single-layer Ka-band reflectarray antenna
Authors: Abdollahvand M. , Forooraghi K. , Encinar Jose A. , Atlasbaf Z. , Martinez-de-Rioja E. 
Published: December 2019

AbstractA novel dual-polarization, single-layer reflectarray has been designed and manufactured to operate at receive (20 GHz) and transmit (30 GHz) frequencies for Ka-band terminal antennas. The reflectarray unit cell is composed of several types of resonant elements printed on the upper side of a conductor-backed substrate, which are designed to produce a collimated beam at 20 and 30 GHz in dual polarization. Cross-shaped loops are used to provide the required phases at 20 GHz, while crossed dipoles and modified truncated rings are used to control the phasing at 30 GHz. The resonant lengths of the proposed elements have been adjusted cell by cell by means of a two-dimensional interpolation method to achieve the required phase shift at each frequency. Two different feeds have been used to illuminate the reflectarray at 20 and 30 GHz. The measured gain is 28.02 dBi at 20 GHz and 32.14 dBi at 30 GHz. The measurement results show that the radiation patterns of the designed single-layer reflectarray antenna are in good agreement with those achieved from the simulations.
Prediction of Anger Expression of Individuals with Psychiatric Disorders using the Developed Computational Codes based on the Various Soft Computing Algorithms
Authors: Moghadasin Maryam 
Published: December 2019

Abstract
Anger is defined as a psychobiological emotional state that consists of feelings varying in intensity from mild irritation or annoyance to intense fury and rage. Dysfunction in anger regulation is marker of most psychiatric disorders. The most important point about anger regulation by the individuals is how to express anger and control it. The purpose of the present study is to predict the anger expression from the anger experience in individuals with psychiatric disorder for assessment of how to express and control the anger. To this end, the number of 3,000 subjects of individuals with clinical disorders had filled in the State-Trait Anger Expression Inventory–II (STAXI–II). After removing the uncertain diagnoses (900 subjects), the number of 2,100 data was considered in the analysis. Then, the computational codes based on three soft computing algorithms, including Radial Basis Function (RBF), Adaptive Neuro-Fuzzy Inference System (ANFIS) and Decision Tree (DT) were developed to predict the scales of anger expression of the individuals with psychiatric disorders. The scales of anger experience were used as input data of the developed computational codes. Comparison between the results obtained from the DT, RBF and ANFIS algorithms show that all the developed soft computing algorithms forecast the anger expression scales with an acceptable accuracy. However, the accuracy of the DT algorithm is better than the other algorithms.
First GIC Estimates for the Mexican Power Grid
Authors: Caraballo R. , González‐Esparza J. A. , Sergeeva M. , Pacheco C. R. 
Published: December 2019

AbstractThis contribution addresses the first assessment of the impact of geomagnetically induced currents (GIC) on the 400‐kV power grid of Mexico. As an initial approach, we modeled GIC using a uniform conductivity for the entire Mexican territory and spatially uniform geomagnetic disturbance. Power grid data were provided by the electric operator of Mexico; the geophysical data were inferred from the main features of Mexican geology. We calculate the power grid response during four geomagnetic storms from Solar Cycles 23 and 24 (i.e., 15 July 2000, 20 October 2003, 17 March 2015, and 7 September 2017), as well as during an extreme scenario (a Carrington‐like event). The results show that the Mexican power grid can be affected by three‐phase GIC ranging from 20 to 75 A during geomagnetic disturbances. According to the model, sites located in coastal areas or close to the edges of the network can experience large GIC during time intervals between 3 and 10 hr, depending on the intensity of the geomagnetic disturbance. It is an interesting result that these sites are of the major economic and strategic significance for the country. In the case of a Carrington‐like event, the power grid could be affected by GIC ranging between 25 and 150 A under a uniform 1 V/km EW geoelectric field. Such an event might produce significant distortions in the grid hardware (i.e., transformers and static VAR compensators), potentially leading to widespread damage.
Achromatic Non-Interferometric Single Grating Neutron Dark-Field Imaging
Authors: Strobl M. , Valsecchi J. , Harti R. P. , Trtik P. , Kaestner A. , Gruenzweig C. , Polatidis E. , Capek J. 
Published: December 2019

AbstractWe demonstrate a simple single grating beam modulation technique, which enables the use of a highly intense neutron beam for differential phase and dark-field contrast imaging and thus spatially resolved structural correlation measurements in full analogy to interferometric methods. In contrast to these interferometric approaches our method is intrinsically achromatic and provides unprecedented flexibility in the choice of experimental parameters. In particular the method enables straight forward application of quantitative dark-field contrast imaging in time-of-flight mode at pulsed neutron sources. Utilizing merely a macroscopic absorption mask unparalleled length scales become accessible. We present results of quantitative dark-field contrast imaging combining microstructural small angle scattering analyses with real space imaging for a variety of materials.
Elevated CO2 and food ration affect growth but not the size-based hierarchy of a reef fish
Authors: McMahon Shannon J. , Munday Philip L. , Wong Marian Y. L. , Donelson Jennifer M. 
Published: December 2019

AbstractUnder projected levels of ocean acidification, shifts in energetic demands and food availability could interact to effect the growth and development of marine organisms. Changes to individual growth rates could then flow on to influence emergent properties of social groups, particularly in species that form size-based hierarchies. To test the potential interactive effects of (1) food availability, (2) elevated CO2 during juvenile development, and (3) parental experience of elevated CO2 on the growth, condition and size-based hierarchy of juvenile fish, we reared orange clownfish (Amphiprion percula) for 50 days post-hatching in a fully orthogonal design. Development in elevated CO2 reduced standard length and weight of juveniles, by 9% and 11% respectively, compared to ambient. Development under low food availability reduced length and weight of juveniles by 7% and 15% respectively, compared to high food. Parental exposure to elevated CO2 restored the length of juveniles to that of controls, but it did not restore weight, resulting in juveniles from elevated CO2 parents exhibiting 33% lower body condition when reared in elevated CO2. The body size ratios (relative size of a fish from the rank above) within juvenile groups were not affected by any treatment, suggesting relative robustness of group-level structure despite alterations in individual size and condition. This study demonstrates that both food availability and elevated CO2 can influence the physical attributes of juvenile reef fish, but these changes may not disrupt the emergent group structure of this social species, at least amongst juveniles.
A compact LED-based projection microstereolithography for producing 3D microstructures
Authors: Behroodi Ebrahim , Latifi Hamid , Najafi Farhood 
Published: December 2019

AbstractProjection microstereolithography (PµSL) is a promising additive manufacturing technique due to its low cost, accuracy, speed, and also the diversity of the materials that it can use. Recently it has shown great potentials in various applications such as microfluidics, tissue engineering, micro-optics, biomedical microdevices, and so on. However, studies on PµSL are still ongoing in terms of the quality and accuracy of the construction process, which particularly affect the fabrication of complex 3D microstructures and make it attractive enough to be considered for commercial applications. In this paper, a compact LED-based PµSL 3D printer for the fabrication of 3D microstructures was developed, and the effective parameters that influence the quality of construction were thoroughly investigated and optimized. Accordingly, a customized optical system, including illumination optics and projection optics, was designed using optical engineering principles. This custom 3D printer was proposed for the PµSL process, which besides improving the quality of construction, led to the reduction of the size of the device, its cost-effectiveness, and the repeatability of its performance. To demonstrate the performance of the fabricated device, a variety of complex 3D microstructures such as porous, hollow, helical, and self-support microstructures were constructed. In addition, the repeatability of the device was assessed by fabricating microstructure arrays. The device performance showed that the lateral accuracy of printing was better than 5 μm, and the smallest thickness of the printed layer was 1 μm. Moreover, the maximum printable size of the device was 6.4 mm × 4 mm × 40 mm.
SMO-M2 mutation does not support cell-autonomous Hedgehog activity in cerebellar granule cell precursors
Authors: Petroni Marialaura , Sahùn Roncero Maria , Ramponi Valentina , Fabretti Francesca , Nicolis Di Robilant Vittoria , Moretti Marta , Alfano Vincenzo , Corsi Alessandro , De Panfilis Simone , Giubettini Maria , Di Giulio Stefano , Capalbo Carlo , Belardinilli Francesca , Coppa Anna , Sardina Francesca , Colicchia Valeria , Pedretti Flaminia , Infante Paola , Cardinali Beatrice , Tessitore Alessandra , Canettieri Gianluca , De Smaele Enrico , Giannini Giuseppe 
Published: December 2019

AbstractGrowth and patterning of the cerebellum is compromised if granule cell precursors do not properly expand and migrate. During embryonic and postnatal cerebellar development, the Hedgehog pathway tightly regulates granule cell progenitors to coordinate appropriate foliation and lobule formation. Indeed, granule cells impairment or defects in the Hedgehog signaling are associated with developmental, neurodegenerative and neoplastic disorders. So far, scant and inefficient cellular models have been available to study granule cell progenitors, in vitro. Here, we validated a new culture method to grow postnatal granule cell progenitors as hedgehog-dependent neurospheres with prolonged self-renewal and ability to differentiate into granule cells, under appropriate conditions. Taking advantage of this cellular model, we provide evidence that Ptch1-KO, but not the SMO-M2 mutation, supports constitutive and cell-autonomous activity of the hedgehog pathway.
Modulation of Wnt/β-catenin signaling promotes blood-brain barrier phenotype in cultured brain endothelial cells
Authors: Laksitorini Marlyn D. , Yathindranath Vinith , Xiong Wei , Hombach-Klonisch Sabine , Miller Donald W. 
Published: December 2019

AbstractWnt/β-catenin signaling is important for blood-brain barrier (BBB) development and is implicated in BBB breakdown under various pathophysiological conditions. In the present study, a comprehensive characterization of the relevant genes, transport and permeability processes influenced by both the autocrine and external activation of Wnt signaling in human brain endothelial cells was examined using hCMEC/D3 culture model. The hCMEC/D3 expressed a full complement of Wnt ligands and receptors. Preventing Wnt ligand release from hCMEC/D3 produced minimal changes in brain endothelial function, while inhibition of intrinsic/autocrine Wnt/β-catenin activity through blocking β-catenin binding to Wnt transcription factor caused more modest changes. In contrast, activation of Wnt signaling using exogenous Wnt ligand (Wnt3a) or LiCl (GSK3 inhibitor) improved the BBB phenotypes of the hCMEC/D3 culture model, resulting in reduced paracellular permeability, and increased P-glycoprotein (P-gp) and breast cancer resistance associated protein (BCRP) efflux transporter activity. Further, Wnt3a reduced plasmalemma vesicle associated protein (PLVAP) and vesicular transport activity in hCMEC/D3. Our data suggest that this in vitro model of the BBB has a more robust response to exogenous activation of Wnt/β-catenin signaling compared to autocrine activation, suggesting that BBB regulation may be more dependent on external activation of Wnt signaling within the brain microvasculature.
The local immune response during Echinococcus granulosus growth in a quantitative hepatic experimental model
Authors: Li Zhide , Zhang Chuanshan , Li Liang , Bi Xiaojuan , Li Liang , Yang Shuting , Zhang Ning , Wang Hui , Yang Ning , Abulizi Abuduaini , Aini Abudusalamu , Lin Renyong , Vuitton Dominique A. , Wen Hao 
Published: December 2019

AbstractThe local immune mechanisms responsible for the establishment and development ofEchinococcus granulosus sensu strictoinfection in the liver, have been little explored. We developed a suitable experimental model that mimics naturally infected livers using portal injection of protoscoleces. Opposite toEchinococcus multilocularisinfection which is dose-dependent, fully mature hydatid cysts can be established in the liver whatever the injection dose; although most of the infection sites were seen at the establishment phase as inflammatory granulomas associated with fibrosis, they never matured into cysts. At the establishment phase, a strong immune response was composed of T and B cells, with T1-type, T2-type cells and cytokines and IL-10-secreting CD8+T cells in the liver. At the established phase, results suggested a local production of antibodies by B cells, and an involvement of NK and NKT cells. Infection outcome and local immune response in the liver, were different in the mouse models ofEchinococcus granulosus sensu strictoandEchinococcus multilocularisrespectively; however, only early specificities at the microenvironment level might explain the major differences found between the lesions induced by the two species. Our quantitative experimental model appears fully appropriate to further study this microenvironment and its relationship with each cestode species.
Gender-specific effects of transthyretin on neural stem cell fate in the subventricular zone of the adult mouse
Authors: Vancamp Pieter , Gothié Jean-David , Luongo Cristina , Sébillot Anthony , Le Blay Karine , Butruille Lucile , Pagnin Maurice , Richardson Samantha J. , Demeneix Barbara A. , Remaud Sylvie 
Published: December 2019

AbstractChoroid plexus epithelial cells produce and secrete transthyretin (TTR). TTR binds and distributes thyroid hormone (TH) to brain cells via the cerebrospinal fluid. The adult murine subventricular zone (SVZ) is in close proximity to the choroid plexus. In the SVZ, TH determines neural stem cell (NSC) fate towards a neuronal or a glial cell. We investigated whether the loss of TTR also disrupted NSC fate choice. Our results show a decreased neurogenic versus oligodendrogenic balance in the lateroventral SVZ of Ttr knockout mice. This balance was also decreased in the dorsal SVZ, but only in Ttr knockout male mice, concomitant with an increased oligodendrocyte precursor density in the corpus callosum. Quantitative RTqPCR analysis following FACS-dissected SVZs, or marked-coupled microbeads sorting of in vitro neurospheres, showed elevated Ttr mRNA levels in neuronal cells, as compared to uncommitted precursor and glial cells. However, TTR protein was undetectable in vivo using immunostaining, and this despite the presence of Ttr mRNA-expressing SVZ cells. Altogether, our data demonstrate that TTR is an important factor in SVZ neuro- and oligodendrogenesis. They also reveal important gender-specific differences and spatial heterogeneity, providing new avenues for stimulating endogenous repair in neurodegenerative diseases.
Ketogenic diet induces skeletal muscle atrophy via reducing muscle protein synthesis and possibly activating proteolysis in mice
Authors: Nakao Reiko , Abe Tomoki , Yamamoto Saori , Oishi Katsutaka 
Published: December 2019

AbstractKetogenic diets (KD) that are very high in fat and low in carbohydrates are thought to simulate the metabolic effects of starvation. We fed mice with a KD for seven days to assess the underlying mechanisms of muscle wasting induced by chronic starvation. This diet decreased the weight of the gastrocnemius (Ga), tibialis anterior (TA) and soleus (Sol) muscles by 23%, 11% and 16%, respectively. The size of Ga, TA, Sol muscle fibers and the grip strength of four limbs also significantly declined by 20%, 28%, 16% and 22%, respectively. The muscle atrophy-related genes Mafbx, Murf1, Foxo3, Lc3b and Klf15 were upregulated in the skeletal muscles of mice fed with the KD. In accordance with the reduced expression of anabolic genes such as Igf1, surface sensing of translation (SUnSET) analyses of fast-twitch Ga, TA and Sol muscles revealed that the KD suppressed muscle protein synthesis. The mRNA expression of oxidative stress-responsive genes such as Sod1 was significantly increased in all muscles examined. In addition to hypercorticosteronemia, hypoinsulinemia and reduced IGF-1, oxidative stress might also be involved in KD-induced muscle atrophy. Feeding mice with a KD is a novel experimental animal model of muscle-wasting induced by chronic starvation.
Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera
Authors: Kim Kidae , Lee Dong Ho , Park Sungryul , Jo Seung-Hyun , Ku Bonsu , Park Sung Goo , Park Byoung Chul , Jeon Yeong Uk , Ahn Sunjoo , Kang Chung Hyo , Hwang Daehee , Chae Sehyun , Ha Jae Du , Kim Sunhong , Hwang Jong Yeon , Kim Jeong-Hoon 
Published: December 2019

AbstractProteolysis targeting chimeras (PROTACs) are an emerging strategy for promoting targeted protein degradation by inducing the proximity between targeted proteins and E3 ubiquitin ligases. Although successful degradation of numerous proteins by PROTACs has been demonstrated, the elements that determine the degradability of PROTAC-targeted proteins have not yet been explored. In this study, we developed von Hippel-Lindau-Cereblon (VHL-CRBN) heterodimerizing PROTACs that induce the degradation of CRBN, but not VHL. A quantitative proteomic analysis further revealed that VHL-CRBN heterodimerizing PROTACs induced the degradation of CRBN, but not the well-known immunomodulatory drug (IMiD) neo-substrates, IKAROS family zinc finger 1 (IKZF1) and −3 (IZKF3). Moreover, truncation of disordered regions of CRBN and the androgen receptor (AR) attenuated their PROTAC-induced degradation, and attachment of the disordered region to stable CRBN or AR facilitated PROTAC-induced degradation. Thus, these results suggest that the intrinsically disordered region of targeted proteins is essential for efficient proteolysis, providing a novel criterion for choosing degradable protein targets.
Capacitive and Sensing Responses of Biomass Derived Silver Decorated Graphene
Authors: Bhujel Rabina , Rai Sadhna , Baruah Khanindram , Deka Utpal , Biswas Joydeep , Swain Bibhu P. 
Published: December 2019

AbstractA new, easy and green method is utilized for producing silver decorated graphene for its application in sensors and supercapacitors. The biomass-derived silver decorated graphene (AgGr) samples are prepared using an APCVD reactor with varying the process temperature from 600 to 800 °C. The as-synthesized AgGr samples were then characterized by AFM, SEM, Raman spectroscopy, FTIR spectroscopy, XRD, cyclic voltammetry and impedance spectroscopy. The interlayer spacing and ID/IG ratio of the AgGr samples varied from 3.6 to 3.7 Å and 0.87 to 1.52, respectively, as the process temperature was raised from 600 to 800 °C. The SEM image shows the distribution of the flower-like structure of Ag flakes in the graphene sheet for the AgGr-800 sample. Also, the greater number of active sites on the surface of AgGr-800 and the presence of a higher number of defects makes it least useful for p-nitrophenol sensing due to the excess opening of the CV curve but has a maximum capacitance of 93.5 Fg−1 in 1 M H2SO4. AgGr-600 showed extremely good sensing of p-nitrophenol than the other AgGr samples. Therefore this novel technique can be utilized for the large scale manufacture of various metal decorated graphene samples for their application in different fields.
MicroRNA profiles of dry secretions through the first three weeks of the dry period from Holstein cows
Authors: Putz Ellie J. , Putz Austin M. , Jeon Hyeongseon , Lippolis John D. , Ma Hao , Reinhardt Timothy A. , Casas Eduardo 
Published: December 2019

AbstractIn dairy cows, the period from the end of lactation through the dry period and into the transition period, requires vast physiological and immunological changes critical to mammary health. The dry period is important to the success of the next lactation and intramammary infections during the dry period will adversely alter mammary function, health and milk production for the subsequent lactation. MicroRNAs (miRNAs) are small non-coding RNAs that can post transcriptionally regulate gene expression. We sought to characterize the miRNA profile in dry secretions from the last day of lactation to 3, 10, and 21 days post dry-off. We identified 816 known and 80 novel miRNAs. We found 46 miRNAs whose expression significantly changed (q-value < 0.05) over the first three weeks of dry-off. Additionally, we examined the slopes of random regression models of log transformed normalized counts and cross analyzed the 46 significantly upregulated and downregulated miRNAs. These miRNAs were found to be associated with important components of pregnancy, lactation, as well as inflammation and disease. Detailing the miRNA profile of dry secretions through the dry-off period provides insight into the biology at work, possible means of regulation, components of resistance and/or susceptibility, and outlets for targeted therapy development.