bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current Paradigms in COVID-19 Research: Proposed Treatment Strategies, Recent Trends and Future Directions
Authors: Sharma Anil K. , Sharma Varruchi , Sharma Arun , Pallikkuth Suresh , Sharma Anil Kumar 
Published: July 2020

Background:Recent pandemic of coronavirus disease caused by a novel coronavirus SARS-CoV-2 in humans is the third outbreak by this family of viruses leading to an acute respiratory infection, which has been a major cause of morbidity and mortality worldwide.The virus belongs to the genus, Betacoronavirus, which has been recently reported to have significant similarity (>89%) to a severe acute respiratory syndrome (SARS)-related member of the Sarbecoviruses. Current researches are not sufficient to understand the etiological and immunopathobiological parameters related to COVID-19 so as to have a therapeutic solution to the problem.Methods:A structured search of bibliographic databases for peer-reviewed research literature has been carried out using focused review questions and inclusion/exclusion criteria. Further Standard tools were implied in order to appraise the quality of retrieved papers. The characteristic outcomes of screened research and review articles along with analysis of the interventions and findings of included studies using a conceptual framework have been described employing a deductive qualitative content analysis methodology.Results:This review systematically summarizes the immune-pathobiological characteristics, diagnosis, potential therapeutic options for the treatment and prevention of COVID-19 based on the current published literature and evidence. The current review has covered 125 peerreviewed articles, the majority of which are from high-income technically developed countries providing the most recent updates about the current understanding of the COVID-19 bringing all the significant findings and related researches together at a single platform. In addition, possible therapeutic interventions, treatment strategies and vaccine development initiatives to manage COVID-19 have been proposed.Conclusions:It is anticipated that this review would certainly assist the public in general and scientific community in particular to recognize and effectively deal with COVID-19, providing a reference guide for futuristic studies.
Emerging Aspects of Photo-catalysts (TiO2 & ZnO) Doped Zeolites and Advanced Oxidation Processes for Degradation of Azo Dyes: A Review
Authors: Hussain Syed M. , Hussain Tabassum , Faryad Moeen , Ali Qasim , Ali Shafaqat , Rizwan Muhammad , Hussain Abdullah I. , Ray Madhumita B. , Chatha Shahzad A.S. 
Published: July 2020

Background:
Azo dyes are recognized as non-decomposable and recalcitrant compounds
and can be depleted into more dangerous secondary products in anaerobic environments. In the current
scenario, different water treatment strategies, including adsorption, photocatalysis, and advanced
oxidation processes based practices, are facing different limitations.

Method:
A literature survey was accomplished by searching the scientific data from different search
engines, including Scopus, PubMed, Science Direct, Springer, Taylor and Francis, Google Scholar,
Blackwell-Synergy, Wiley-Interscience and Research-Gate, etc. This article has been compiled after
intensively reviewing about 231 research papers, reviews, and book chapters in the fields of industrial
effluents, hazardous materials, and water treatment strategies with their advantages and limitations.

Results:
Molecular oxygen and other active species, such as O2•−, HO2•, H2O2, and •OH, play a significant
role in the degradation of dyes in AOPs and photocatalyst utilizes sunlight energy and accelerates
some chemical reactions depending upon the activation energies. Different reaction parameters,
including calcination temperature, pH, initial dye concentration, and catalyst dosage, have a significant
impact on photocatalytic degradation performance. Characterization of degradation processes
of dye-stuffs could be carried out by the state-of-the-art analytical techniques i.e. UV-Visible
spectroscopy, powdered XRD, FTIR (ATR), EDX-SEM, BET, and differential pulse voltammetry.
GC-MS and LC-MS investigation of photodegradation by-products and intermediates could provide
identification and possible degradation pathway for target dye molecules. This review covers research
related to photocatalytic degradation of azo dyes by TiO2 and ZnO, widely used photocatalysts,
and various combinations of zeolites.

Conclusion:
It can be concluded that the combination of nano-sorbents (Fly Ash Zeolites) and photocatalysts
not only enhances the degradation but also effectively removes toxic dye molecules and
their by-products. The review explains the suitability of synergic applications of catalysts (TiO2,
ZnO) and catalytic bed (zeolites) for different industrial effluents and waste water treatment at a significant
pace towards green technology.
Colorectal Cancer Classification and Survival Analysis Based on an Integrated RNA and DNA Molecular Signature
Authors: Mohammed Mohanad , Mwambi Henry , Omolo Bernard 
Published: July 2020

Background:
Colorectal cancer (CRC) is the third most common cancer among women
and men in the USA, and recent studies have shown an increasing incidence in less developed
regions, including Sub-Saharan Africa (SSA). We developed a hybrid (DNA mutation and RNA
expression) signature and assessed its predictive properties for the mutation status and survival of
CRC patients.

Methods:
Publicly-available microarray and RNASeq data from 54 matched formalin-fixed
paraffin-embedded (FFPE) samples from the Affymetrix GeneChip and RNASeq platforms, were
used to obtain differentially expressed genes between mutant and wild-type samples. We applied
the support-vector machines, artificial neural networks, random forests, k-nearest neighbor, naïve
Bayes, negative binomial linear discriminant analysis, and the Poisson linear discriminant analysis
algorithms for classification. Cox proportional hazards model was used for survival analysis.

Results:
Compared to the genelist from each of the individual platforms, the hybrid genelist had
the highest accuracy, sensitivity, specificity, and AUC for mutation status, across all the classifiers
and is prognostic for survival in patients with CRC. NBLDA method was the best performer on the
RNASeq data, while the SVM method was the most suitable classifier for CRC across the two data
types. Nine genes were found to be predictive of survival.

Conclusion:
This signature could be useful in clinical practice, especially for colorectal cancer
diagnosis and therapy. Future studies should determine the effectiveness of integration in cancer
survival analysis and the application on unbalanced data, where the classes are of different sizes,
as well as on data with multiple classes.
Snake Venom Proteins Isolated from Tunisian Vipers: Pharmacological and Therapeutic Overview
Authors: Morjen Maram , Abdelkafi-Koubaa Zaineb , Jebali Jed , Messadi Erij , Srairi-Abid Najet , Luis José , Marrakchi Naziha 
Published: July 2020

:
The venoms of Tunisian wildlife snakes are complex mixtures containing proteins/
peptides and non-protein molecules. Proteins and peptides are the most abundant compounds
responsible for the biological effects of venoms. Snake venoms proteins have enzymatic or nonenzymatic
activities, which are grouped into different families, including C-type lectin proteins,
disintegrins (long, medium and short disintegrins), Kunitz-type serine protease inhibitors, natriuretic-
like peptides, vascular endothelial growth factor-related proteins, L-amino acid oxidases,
phospholipases A2 and serine proteinases. With technological advancements, the toxic effects of
venoms were turned into potential benefits for clinical diagnosis, basic research and development of
new research tools and drugs of potential clinical use. Our research team has shown that Macrovipera
lebetina and Cerastes cerastes venom components of Tunisian wildlife snakes had great potential
for the development of new drugs for the treatment of cancer, angiogenesis disorders or cardiovascular
diseases. This review is an overview of snake venom proteins from Macrovipera lebetina
and Cerastes cerastes and their biochemical, pharmacological and molecular characterization
and their importance as protein resources with therapeutic potential.
THE DIFFUSION OF VALUE EDUCATION MODEL IN EARLY CHILDHOOD THROUGH TRADITIONAL SONGS AND GAMES
Authors: Hajaroh Mami , Rukiyati Rukiyati , Pamungkas Joko 
Published: July 2020

This study was aimed at diffusing the value education model through traditional songs and games for kindergarten teachers in Yogyakarta. This model is an early childhood learning innovation for value education. Diffusion research is a study to disseminate models to teachers; therefore the research subjects were kindergarten teachers. The subject of this study in Kindergarten Schools in DIY included 15 kindergarten schools in Bantul, Sleman, Kulonprogo, Bantul and Yogyakarta city regencies involving 32 teachers. The data were gathered using focus group discussions and questionnaires. The data then analyzed using mixed descriptive qualitative and quantitative methods. This study proves that the model of value education in early childhood through traditional songs and games has five characteristics as innovations which have the advantages of relative, compatibility, complexity, can be tested and can be observed. In addition, in the process of disseminating to the teacher through five stages of diffusion, namely: knowledge, persuasion, decision, implementation, and confirmation. Teachers also tend to use traditional songs and games to inculcate religious values which are the school's peculiarities.DIFUSI MODEL PENDIDIKAN NILAI PADA ANAK USIA DINI MELALUI LAGU DAN PERMAINAN TRADISIONALPenelitian ini bertujuan untuk mendifusikan model pendidikan nilai melalui lagu dan permainan (dolanan) tradisional pada guru taman kanak-kanak ‘Aisyiyah di Daerah Istimewa Yogyakarta (DIY). Model ini merupakan inovasi pembelajaran anak usia dini untuk pendidikan nilai. Penelitian difusi merupakan penelitian untuk menyebarluaskan model kepada para guru; oleh karena itu subyek penelitian adalah guru taman kanak-kanak. Subjek penelitian ini di Sekolah Taman Kanak-kanak di DIY meliputi 15 sekolah Taman-Kanak-kanak di Kabupaten Bantul, Sleman, Kulonprogo, Bantul dan Kota Yogyakarta melibatkan 32 orang guru. Pengumpulan data menggunakan focus group discussion dan kuisioner. Analisis data secara deskriptif kualitatif dan kuantitatif. Penelitian ini membuktikan bahwa model pendidikan nilai pada anak usia dini melalui lagu dan dolanan memiliki lima karakterisik sebagai inovasi yakni memiliki keunggulan relative, kompatibilitas, kompleksitas, dapat diujicoba dan dapat diamati. Selain itu dalam proses penyebarluasan kepada guru melewati lima tahap difusi yakni: pengetahuan, persuasi, keputusan, implementasi, dan konfirmasi. Guru juga cenderung menggunakan lagu dan permainan tradisional untuk menanamkan nilai-nilai keagamaan yang merupakan kekhasan sekolah.
CHARACTER EDUCATION VALUE IN FOLK GAMES ON MERAPI MOUNTAIN SLOPE
Authors: Solihati Nani , Hikmat Ade , Jupri Abdul Rahman , Hidayatullah Syarif 
Published: July 2020

This study was aimed at determining the value of character education in folk games on the slopes of Mount Merapi. This study used qualitative method. The subjects of this study were students, teachers, principals, and heads of Cangkringan and Pakem sub-education technical implementation unit. The instruments used were in-depth observations and interviews. The result shows that there are seventeen folk games, namely dakon, serak lidi, lompat tali, enggrang, bekelan, kelereng, bentengan, dan bola bakar, oya dodok, oya tembok, jamuran, cublak-cublak suweng, petak umpet, engklak, dingklik oglak-aglik, gobak sodor, and elang ayam.The game is used by teachers on the slopes of Mount Merapi to instill thirteen characters from eighteen educational characters. These characters, namely honesty, tolerance, discipline, hard work, creative, independent, democratic, curiosity, respect for achievement, friendship, caring for the environment, social care, and responsibility. Folk games should be integrated in learning in elementary school to develop student characterNILAI PENDIDIKAN KARAKTER DALAM PERMAINAN RAKYAT DI LERENG GUNUNG MERAPIPenelitian ini bertujuan untuk mengeksplorasi nilai pendidikan karakter dalam permainan rakyat di lereng gunung Merapi. Metode kualitatif digunakan dalam penelitian ini. Subjek penelitian ini adalah siswa sekolah dasar (SD), guru, kepala sekolah, dan kepala Unit Pelaksana Teknis sub pelayanan pendidikan di kecamatan Cangkringan dan kecamatan Pakem. Instrumen yang digunakan adalah lembar observasi dan pedoman wawancara. Hasil penelitian mengidentifikasi tujuh belas permainan rakyat, yaitu dakon, serak lidi, lompat tali, enggrang, bekelan, kelereng, bentengan, dan bola bakar, oya dodok, oya tembok, jamuran, cublak-cublak suweng, petak umpet, engklak, dingklik oglak-aglik, gobak sodor, dan elang ayam yang berpotensi sebagai sarana penanaman nilai karakter pada siswa SD. Permainan tersebut dimanfaatkan oleh para guru yang ada di lereng gunung Merapi untuk menanamkan tiga belas karakter dari delapan belas karakter pendidikan. Karakter tersebut, yaitu jujur, toleransi, disiplin, kerja keras, kreatif, mandiri, demokratis, rasa ingin tahu, menghargai prestasi, bersahabat, peduli lingkungan, peduli sosial, dan tanggung jawab. Permainan rakyat semestinya dapat diintegrasikan dalam pembelajaran di SD untuk mengembangkan karakter siswa.
CHARACTER EDUCATION IN FAMILY THROUGH PARENTING PATTERN
Authors: Wulandari Taat , Wijayanti Agustina Tri , Saliman Saliman 
Published: July 2020

This study was aimed at revealing the role and the capital of parenting towards children in an effort to shape the character of tolerance and caring for the environment. The study used qualitative naturalistic research methods. The techniques of collecting data used were observation, interviews, and documentation. The data then analyzed using interactive analysis proposed by Miles and Huberman. The results show that the role of parents in shaping the character of tolerance and caring for the environment through parents as motivators, as supervisors, as physical and spiritual protectors, as mentors, educating and as role models or role models to choose and shape children. The formation of the character of tolerance and caring for the children is given through debriefing skills to respect friends, stimulation activities, and positive habituation application. The pattern of positive habituation of parents is in the form of familiarizing children to do good activities. Parents provide firmness to the child's character of tolerance and caring for the environment. The model of parenting is applied as authoritarian parenting, democratic and situational.PENDIDIKAN KARAKTER DALAM KELUARGA MELALUI POLA ASUH ORANG TUAPenelitian ini bertujuan untuk mengungkapkan peran dan modal pola asuh orang tua terhadap anak dalam upaya membentuk karakter toleransi dan peduli lingkungan. Penelitian menggunakan metode penelitian kualitatif naturalistik. Teknik pengumpulan data menggunakan observasi, wawancara, dan dokumentasi. Teknik analisis data menggunakan analisis interaktif Miles dan Huberman. Hasil penelitian menunjukkan bahwa peran orang tua dalam membentuk karakter toleransi dan peduli lingkungan dapat melalui orang tua sebagai motivator, sebagai pengawas, sebagai pelindung jasmani dan rohani, sebagai pembimbing, mendidik dan sebagai panutan atau role model untuk memilihara dan membentuk anak. Pembentukan karakter toleransi dan peduli lingkungan pada anak diberikan melalui pemberin bekal keterampilan untuk saling menghargai dengan sesama teman, orang tua membentuk kegiatan yang merangsang karakter toleransi dan peduli lingkungan, orang tua menerapkan pembiasaan yang positif. Pola pembiasaan positif orang tua dilakukan dengan membiasakan anak melakukan kegiatan yang baik. Orang tua memberikan ketegasan terhadap anak karakter toleransi dan peduli lingkungan. Model pola asuh orang tua yang diterapkan seperti pola asuh otoriter; demokratis dan situasional.
KURIKULUM PENDIDIKAN BAHASA DALAM PERSPEKTIF INOVASI PEMBELAJARAN
Authors: Suryaman Maman , Musfiroh Tadkiroatun , Purbani Widyastuti 
Published: July 2020

Penelitian ini bertujuan untuk mendeskripsikan kurikulum bahasa dalam perspektif inovasi pembelajaran ditinjau dari Kerangka Kualifikasi Nasional Indonesia (KKNI) dan Standar Nasional Pendidikan Tinggi (SN-Dikti). Desain penelitian yang digunakan adalah deskriptif kualitatif dengan metode analisis isi. Sumber data berupa naskah Kurikulum Program Studi Pendidikan Bahasa Inggris dan Pendidikan Bahasa Prancis, Fakultas Bahasa dan Seni Universitas Negeri Yogyakarta. Instrumen berupa human instrument dilengkapi dengan lembar analisis untuk menelaah dokumen. Analisis data dilakukan secara deskriptif kualitatif dibantu kuantitatif. Kredibilitas penelitian dicapai melalui reliabilitas interater. Hasil penelitian ini adalah sebagai berikut. Pertama, profil lulusan belum dirumuskan berdasarkan realitas profesi yang ada di lapangan sehingga belum secara optimal dapat memberikan pemahaman tentang pengalaman belajar yang dirumuskan melalui capaian pembelajaran. Kedua, kompetensi belum dielaborasi secara lengkap dan relevan ke dalam capaian pembelajaran, profil lulusan, dan model pembelajaran. Ketiga, rumusan kompetensi sikap sudah menjadi bagian dari penyemaian dan pembentukan konsepsi dan perilaku individu tentang kesadaran identitas kebangsaan dan kenegaraan. Namun, kompetensi penguasaan pengetahuan, keterampilan khusus, dan keterampilan umum belum lengkap dan relevan dengan pembelajaran inovatif. LANGUAGE EDUCATION CURRICULUM IN LEARNING INNOVATION PERSPECTIVEThis study was aimed at describing the language education curriculum in the perspective of learning innovation at the Faculty of Languages and Arts, Yogyakarta State University in reference of Indonesian Qualifiation Framework (IQF) and National Higher Education Standards (NHES). The research design used descriptive qualitative and content analysis method. The data were obtained from the curriculum texts of English Language Education and French Language Education Study Programs. Human instrument equipped with an analysis sheet was used to review the data. The data then analyzed using the descriptive analysis method. The credibility of this study was achieved through an inter-rater reliability. The results show that: first, the profile of graduates has not been formulated based on the reality of the field profession so that it has not been able to optimally provide an understanding of learning experiences formulated through learning outcomes. Second, the competencies have not been elaborated completely and relevant into learning outcomes, graduate profiles, and learning models. Third, the formulation of attitude competencies has become part of the seeding and formation of individual conceptions and behaviors about national and state identity awareness, but the competence in mastering knowledge, special skills, and general skills is not yet complete and relevant to innovative learning.
THE EFFECT OF TRICHODERMA SP. SEED COATING AND THE APPLICATION OF BOKASHI TOWARD SOYBEAN YIELD
Authors: Winara Intan , Sumadi Sumadi , Nuraini Anne 
Published: July 2020

This study was aimed at determining the effect of seed coating using Trichoderma sp. and applying bokashi to increase soybean yields. The study was carried out in the Ciparanje experimental garden of Padjadjaran University in Jatinangor in April to July 2017. The design used in this study was a Randomized Block Design which was repeated three times. The soybean seeds used are Anjasmoro varieties. Tricho-G as a source of Trichoderma sp. was used as a seed coating material. Bokashi cow manure and the soil used were from paddy fields. Other ingredients used were Urea, SP-36, KCl, and pesticides with the active ingredient Profenofos. The step of the research is bokashi application, seed coating, storage, planting, fertilizer application, and observation. The results show that the combination of seed coating using Trichoderma sp. and bokashi application had an effect on increasing the number and weight of seeds per plant. Coating of seeds with Trichoderma sp. low doses can still maintain plant growth and has a positive effect on crop yields.PENGARUH PELAPISAN BENIH TrichoDERMA SP. DAN PEMBERIAN BOKASHI TERHADAP HASIL PANEN KEDELAIPenelitian ini bertujuan untuk mengetahui pengaruh pelapis benih menggunakan Tricho-derma sp. dan pemberian bokashi terhadap peningkatan hasil panen kedelai. Penelitian dilaksanakan di kebun percobaan Ciparanje Universitas Padjadjaran Jatinangor pada bulan April sampai dengan Juli 2017. Rancangan yang digunakan dalam penelitian ini yaitu Rancangan Acak Kelompok yang diulang tiga kali. Benih kedelai yang digunakan yaitu varietas Anjasmoro. Tricho-G sebagai sumber Trichoderma sp. digunakan sebagai bahan pelapis benih. Pupuk Bokashi kotoran sapi dan tanah yang digunakan berasal dari tanah sawah. Bahan-bahan lain yang digunakan yaitu pupuk Urea, SP-36, KCl, dan pestisida dengan bahan aktif Profenofos. Langkah penelitian yang dilakukan adalah pemberian bokashi, pelapisan benih, penyimpanan, penanaman, pemupukan, dan pengamatan. Berdasarkan hasil penelitian ini dapat disimpulkan bahwa kombinasi pelapisan benih menggunakan Trichoderma sp. dan pemberian bokashi berpengaruh dalam meningkatkan jumlah dan bobot biji per tanaman. Pelapisan benih dengan Trichoderma sp. dosis rendah masih dapat mempertahankan pertumbuhan tanaman dan memberikan pengaruh yang positif terhadap hasil tanamaN