bluuebunny/crossref_metadata_2025_split huggingface dataset:
CYGNSS Ocean Surface Wind Validation in the Tropics
Authors: Asharaf Shakeel , Waliser Duane E. , Posselt Derek J. , Ruf Christopher S. , Zhang Chidong , Putra Agie W. 
Published: December 2020

AbstractSurface wind plays a crucial role in many local/regional weather and climate processes, especially through the exchanges of energy, mass, and momentum across Earth’s surface. However, there is a lack of consistent observations with continuous coverage over the global tropical ocean. To fill this gap, the NASA Cyclone Global Navigation Satellite System (CYGNSS) mission was launched in December 2016, consisting of a constellation of eight small spacecrafts that remotely sense near-surface wind speed over the tropical and subtropical oceans with relatively high sampling rates both temporally and spatially. This current study uses data obtained from the Tropical Moored Buoy Arrays to quantitatively characterize and validate the CYGNSS derived winds over the tropical Indian, Pacific, and Atlantic Oceans. The validation results show that the uncertainty in CYGNSS wind speed, as compared with these tropical buoy data, is less than 2 m s−1 root-mean-square difference, meeting the NASA science mission level-1 uncertainty requirement for wind speeds below 20 m s−1. The quality of the CYGNSS wind is further assessed under different precipitation conditions, and in convective cold-pool events, identified using buoy rain and temperature data. Results show that CYGNSS winds compare fairly well with buoy observations in the presence of rain, though at low wind speeds the presence of rain appears to cause a slight positive wind speed bias in the CYGNSS data. The comparison indicates the potential utility of the CYGNSS surface wind product, which in turn may help to unravel the complexities of air–sea interaction in regions that are relatively undersampled by other observing platforms.
Do Obese Breast Cancer Patients Have More Complications and a Longer Length of Stay After Mastectomy Than Nonobese Patients?
Authors: Wang Melinda , Huang Julian , Chagpar Anees B. 
Published: December 2020

Background While obesity is thought to increase complication rates in general surgery procedures, its effect in mastectomy patients remains to be fully elucidated. We sought to determine if obesity is associated with a higher complication rate and length of stay after mastectomy, independent of clinicopathologic and treatment factors. Methods Medical records of breast cancer patients undergoing mastectomy at our institution between January 2010 and December 2017 were retrospectively reviewed. Patients were separated into obese (body mass index [BMI] ≥ 30) and nonobese (BMI < 30) categories and compared using nonparametric statistical analyses. Results Of 927 patients, 291 (31.2%) were obese. Obese patients had more complications (26.5% vs. 20.0%, P = 0.033) and a greater number of complications per patient ( P = 0.025) than nonobese patients. They were more likely to have infections (10.7% vs. 5.7%, P = .009), flap thrombosis/necrosis (5.5% vs. 2.4%, P = .018), and skin breakdown/wound complications (8.6% vs. 4.6%, P = .022). Additionally, obese patients had longer hospital length of stay (LOS; LOS > 2 days: 77.7% vs. 65.2%, P < .001). Controlling for potential confounders, obesity remained associated with a higher rate of thrombosis/necrosis of flap (odds ratio [OR] = 2.26; 95% confidence interval [CI] 1.01-5.08; P = .047) and LOS ≥ 2 days (OR = 1.82; 95% CI 1.23-2.69; P = .003). Conclusion Obese breast cancer patients undergoing mastectomy have more thrombosis/necrosis of flap and a longer hospital LOS than nonobese patients, regardless of other comorbidities and clinicopathologic/treatment factors.
Sculptorades, Cloodles, and Cameos, Oh My! A Cranium Game for General Psychology
Authors: Goldey Katherine L. , Espinosa Angel 
Published: December 2020

Background: Many instructors use trivia-style review games to encourage self-testing, increase student engagement, and promote collaboration. However, most published examples of review games include trivia questions only, rather than activities that incorporate kinesthetic learning. Objective: We evaluate a review activity modeled after the game Cranium, which includes charades, pictionary, sculpting, and trivia questions. Method: In Pilot Study 1, general psychology students ( n = 25) completed a self-report evaluation of Cranium, and we compared performance on exam items practiced during Cranium versus control items. In Pilot Study 2, students ( n = 23) were assigned to review for a mock exam via Cranium, a trivia-only version of Cranium, or a practice question review. Results: Students rated Cranium as enjoyable and useful, though not more so than comparison activities, and Cranium elicited similar exam performance to comparison activities. Conclusion: Cranium is similar, not superior, to trivia-only and practice question review activities in terms of student perceptions and exam performance. Teaching Implications: Cranium provides an additional tool for instructors to engage students in team-based review activities in general psychology. Games that incorporate self-testing are likely useful for student engagement and learning, and the specific choice of activity may depend on instructor and student preference.
A Mixed-Methods Approach to Evaluate the Needs, Support, and Services for Common Mental Disorders: A Protocol Examining Two Community Extension Clinics
Authors: Mehta Varun S. , Ram Daya 
Published: December 2020

Background: The social, economic, and physical environments are widely recognized as important determinants of health and affect the outcome of service delivery. The differences in the patient outcomes can be inferred upon by looking into the process and content of service delivery. Methods: This study is a mixed-methods, prospective cohort study to be conducted at two community extension clinics run by the Central Institute of Psychiatry, Ranchi, Jharkhand. Service users diagnosed with a common mental disorder (CMDs) will be recruited during the study period of three years. The main objective is to ascertain the unmet needs of patients with CMDs. The secondary goals involve measuring the clinical outcome through the lens of process-oriented recovery, service satisfaction, and accessibility, and analyzing the barriers to access healthcare services along with the impact on the carers. Focus group discussions with participants will help understand the reasons behind their unmet needs and factors essential in service delivery. Discussion: Healthcare, as well as social care, aims to deliver services according to need. In a country with 15 million people with CMDs, evaluation of needs could create a platform for the rational distribution of services.
Frequency and characteristics of the JAK2 V617F mutation in 23 cerebral venous sinus thrombosis patients with thrombocytosis
Authors: Ma Qiang 
Published: December 2020

Objective To analyse the frequency and characteristics of the Janus kinase 2 ( JAK2) V617F mutation in patients with cerebral venous sinus thrombosis (CVST) with thrombocytosis. Methods The study enrolled CVST patients with thrombocytosis that had undergone JAK2 V617F mutation detection to determine the frequency of the JAK2 V617F mutation in this cohort. Correlations between patient demographics, whole blood cell counts, targeted sequencing results and JAK2 V617F mutation status were determined. Results A total of 23 patients were enrolled in the study: 11 (47.8%) with the JAK2 V617F mutation and 12 (52.2%) without the JAK2 V617F mutation. The mean platelet count was significantly higher in patients with the JAK2 V617F mutation than in patients without the mutation (478.1 ± 107.4 × 109/l versus 374.4 ± 54.1 × 109/l, respectively). There were no significant differences in age, sex, white blood cell count or haemoglobin level between the two groups. Other than single nucleotide polymorphisms, no hot-spot mutations associated with myeloid tumours other than the JAK2 V617F mutation were detected in four CVST patients that underwent targeted sequencing. Conclusion The JAK2 V617F mutation was frequently detected in CVST patients with thrombocytosis and it was associated with higher platelet counts.
A Quasi-Experimental Study on Training Child Welfare Workers on Youth Sexual Health
Authors: Combs Katie Massey , Taussig Heather 
Published: December 2020

Purpose: This quasi-experimental pilot study evaluated the preliminary efficacy of training designed to increase child welfare workers’ ( N = 156) knowledge, attitudes, and behaviors related to communicating with youth involved in the child welfare system about sexual and reproductive health (SRH). Method: Preintervention and 3-month follow-up survey data were collected from intervention participants ( n = 69) who registered for a sexual health training and comparison participants ( n = 87) who registered for other child welfare trainings. Results: Participants in the SRH training showed more positive behavioral beliefs, self-efficacy, and knowledge of SRH compared to date- and region-matched comparison participants at the 3-month follow-up; there was no difference between the groups on intentions or past month communication with clients regarding SRH. Conclusion: Findings suggest that although SRH training may be effective in changing child welfare workers’ attitudes about SRH, additional efforts may be needed to alter intentions and behaviors.
A Participatory, State–Community–Academic Model to Improve Pregnancy Outcomes in Texas: The Healthy Families Initiative
Authors: Patel Divya A. , Salahuddin Meliha , Valerio Melissa , Elerian Nagla , Matthews Krystin J. , McGaha Paul , Nelson Robert , Lakey David L. 
Published: December 2020

Background While the Texas infant mortality rate (IMR) is below the Healthy People 2020 objective (5.7 per 1,000 live births), stark differences in IMR are seen across Texas communities. Health indicators for the state suggest important missed opportunities for improving maternal and infant outcomes. The Healthy Families initiative was a collaboration between a Texas state agency, community partners, and academic institutions to understand how evidence-based interventions could be identified, adapted, and implemented to address community priorities and reduce disparities in pregnancy outcomes. Method The Healthy Families initiative included two Texas counties, one with low utilization of prenatal care and one with persistent disparities in infant mortality. The model served to (1) identify community factors influencing IMR and maternal morbidity through stakeholder engagement and secondary data, (2) build community capacity to link pregnant women with existing and newly developed services, and (3) develop partnerships within the community and clinics to improve access to and sustainability of services. Results A community-based participatory approach focused on stakeholder engagement was used to identify, design, and adapt strategies to address community-identified priorities. Conclusions The Healthy Families initiative is a unique state–community–academic partnership aimed at improving pregnancy outcomes in vulnerable communities, with a focus on promotion of capacity building, maintenance, and sustainability of maternal and infant health programs.
Umbilical cord-derived mesenchymal stem cell implantation in patients with optic atrophy
Authors: Kahraman Neslihan Sinim , Öner Ayşe 
Published: December 2020

Background: Optic nerve cells can be irreversibly damaged by common various causes. Unfortunately optic nerve and retinal ganglion cells have no regenerative capacity and undergo apoptosis in case of damage. In this study, our aim is to investigate the safety and efficacy of suprachoroidal umbilical cord-derived MSCs (UC-MSCs) implantation in patients with optic atrophy. Methods: This study enrolled 29 eyes of 23 patients with optic atrophy who were followed in the ophthalmology department of our hospital. BCVA, anterior segment, fundus examination, color photography, and optical coherence tomography (OCT) were carried out at each visit. Fundus fluorescein angiography and visual field examination were performed at the end of the first, third, sixth months, and 1 year follow-up. Results: After suprachoroidal UC-MSCs implantation there were statistically significant improvements in BCVA and VF results during 12 months follow-up ( p < 0.05). When we evaluate the results of VF tests, the mean deviation (MD) value at baseline was −26.11 ± 8.36 (range −14.18 to −34.41). At the end of the first year it improved to −25.01 ± 8.73 (range −12.56 to −34.41) which was statistically significant ( p < 0.05). When we evaluate the mean RNFL thickness measurements at baseline and at 12 month follow-up the results were 81.8 ± 24.9 μm and 76.6 ± 22.6 μm, respectively. There was not a significant difference between the mean values ( p > 0.05). Conclusion: Stem cell treatment with suprachoroidal implantation of UCMSCs seems to be safe and effective in the treatment for optic nerve diseases that currently have no curative treatment options
A novel video overlay guided enlargement of area of ILM peeled versus inverted flap technique: A long-term study in large macular holes
Authors: Boral Subhendu Kumar , Agarwal Deepak , Das Arnab , Chakraborty Debdulal , Sinha Tushar Kanti 
Published: December 2020

Background/Aim: To compare the intra-operative video overlay guided enlargement of Area of ILM peeled (AIP) more than three Disc Diameter (DD) versus the inverted flap technique in large (>400 µm ) Full Thickness Macular Holes (FTMH). Methods: Retrospectively, 127 cases of large FTMHs divided into two groups (i) Group A ( n = 62)—intra-operative video-overlay guided enlargement of AIP > 3DD performed and (ii) Group B ( n = 65)—Inverted flap technique was done. Mean Best Corrected Visual Acuity (BCVA), hole closure rate and postoperative foveal anatomy were noted on Optical Coherence Tomography (OCT). Results: Mean Minimal Diameter of Macular Hole (MDMH) were 632.05 ± 146.62 µm (A) and 677.24 ± 152.08 µm (B). Hole closure rate were 93.55% (A) and 96.92% (B). Mean preoperative BCVA was 1.07 ± 0.37 Log MAR (A) and 0.94 ± 0.23 Log MAR (B). Mean postoperative BCVA at 3 months were 0.73 ± 0.22 Log MAR (A) and 0.83 ± 0.24 Log MAR (B). One-way ANOVA test showed statistically better visual improvement in Group A at 3 months ( p = 0.02), 6 months ( p = 0.045), 12 months ( p = 0.002), and 24 months ( p = 0.011). Chi square test revealed Type I pattern of hole closure was statistically more in Group B ( p < 0.001). Delayed Recovery of Outer Retinal Layers was more in group B (Pearson Chi square test, p = 0.039). Conclusion: Anatomically, macular hole closure rate as well as closure pattern was better in Group B. But functional improvement was better in Group A.
Femtosecond laser assisted in situ keratomileusis (FS-LASIK) yields better results than transepithelial photorefractive keratectomy (Trans-PRK) for correction of low to moderate grade myopia
Authors: Gershoni Assaf , Reitblat Olga , Mimouni Michael , Livny Eitan , Nahum Yoav , Bahar Irit 
Published: December 2020

Introduction: The purpose of this study was to compare the outcomes of transepithelial photorefractive keratectomy (Trans-PRK) with femtosecond laser assisted in situ keratomileusis (FS-LASIK) for the correction of low to moderate myopia. Methods: A retrospective cohort study design was used. The study group included patients with myopia less than −6.0 D, with or without concomitant astigmatism under 2.0 D, who were treated with FS-LASIK or Trans-PRK in 2013 through 2014. Background, clinical and outcome data were collected from the patient files. A comparison between eyes treated with FS-LASIK or Trans-PRK was performed. Results: The Trans-PRK group was comprised of 1793 eyes and the FS-LASIK group of 666 eyes. Mean ± SD spherical equivalent (SE) refraction prior to surgery was −3.43 ± 1.27 D in the Trans-PRK group and −3.18 ± 1.34 D in the FS-LASIK group ( p < 0.001). Efficacy index values were 0.95 ± 0.14 in the Trans-PRK group and 0.98 ± 0.12 in the FS-LASIK group ( p < 0.001), and corresponding safety index values were 0.96 ± 0.13 and 0.99 ± 0.12 ( p < 0.001). Distance from target refraction was 0.45 ± 0.42 D in Trans-PRK group and 0.43 ± 0.38 D in the FS-LASIK group ( p = 0.537); 71.6% and 74.2% of eyes were within ±0.5 D of attempted correction, respectively ( p = 0.193) Conclusions: Both Trans-PRK and FS-LASIK demonstrated excellent results, mostly comparable with the current literature. FS-LASIK achieved better results than Trans-PRK surgery in the efficacy and safety parameters.
Korean American Smokers’ Perspectives on Mobile Smoking Cessation Applications
Authors: Moon Joonwoo , Rigg Julaine S , Smith Janice E 
Published: December 2020

Introduction: The primary purpose of this research is to investigate the adoption process of mobile smoking cessation apps for Korean American smokers with the eventual purpose of proposing a new combined model of smartphone smoking cessation adoption. Methods: From September 2018 to March 2019, a total of 227 Korean American smokers responded to surveys regarding the effectiveness of mobile applications for smoking cessation. A path analysis was used to analyze the predictors of adopting and using smoking cessation applications available via smartphones. Results: Perceived benefits and self-efficacy were important factors for influencing the perceived usefulness of a smoking cessation mobile app. Moreover, the perceived usefulness of a smoking cessation mobile app was also positively related to intention to use a smoking cessation mobile app. Conclusion: Although mobile smoking cessation apps can help many individuals quit smoking, most Korean American smokers are not current users of smoking cessation mobile apps. Therefore, there is a strong need to use strategic evidence-based communication interventions for promoting the widespread adoption of smoking cessation applications.
Tools and Techniques Used With Robotic Devices to Quantify Upper-Limb Function in Typically Developing Children: A Systematic Review
Authors: Dobri Stephan CD , Ready Hana M , Davies Theresa Claire 
Published: December 2020

Background: Robotic devices have been used to quantify function, identify impairment, and rehabilitate motor function extensively in adults, but less-so in younger populations. The ability to perform motor actions improves as children grow. It is important to quantify this rate of change of the neurotypical population before attempting to identify impairment and target rehabilitation techniques. Objectives: For a population of typically developing children, this systematic review identifies and analyzes tools and techniques used with robotic devices to quantify upper-limb motor function. Since most of the papers also used robotic devices to compare function of neurotypical to pathological populations, a secondary objective was introduced to relate clinical outcome measures to identified robotic tools and techniques. Methods: Five databases were searched between February 2019 and August 2020, and 226 articles were found, 19 of which are included in the review. Results: Robotic devices, tasks, outcome measures, and clinical assessments were not consistent among studies from different settings but were consistent within laboratory groups. Fifteen of the 19 articles evaluated both typically developing and pathological populations. Conclusion: To optimize universally comparable outcomes in future work, it is recommended that a standard set of tasks and measures is used to assess upper-limb motor function. Standardized tasks and measures will facilitate effective rehabilitation.
Serum ceramide levels are altered in multiple sclerosis
Authors: Filippatou Angeliki G , Moniruzzaman Mohammed , Sotirchos Elias S , Fitzgerald Kathryn C , Kalaitzidis Grigorios , Lambe Jeffrey , Vasileiou Eleni , Saidha Shiv , Prince Jerry L , Haughey Norman , Calabresi Peter A , Bhargava Pavan 
Published: December 2020

Background: Sphingolipids are myelin components and inflammatory signaling intermediates. Sphingolipid metabolism may be altered in people with multiple sclerosis (PwMS), but existing studies are limited by small sample sizes. Objectives: To compare the levels of serum ceramides between PwMS and healthy controls (HCs) and to determine whether ceramide levels correlate with disability status, as well as optical coherence tomography (OCT)-derived rates of retinal layer atrophy. Methods: We performed targeted lipidomics analyses for 45 ceramides in PwMS ( n = 251) and HCs ( n = 68). For a subset of PwMS, baseline and 5-year Expanded Disability Status Scale (EDSS) assessments ( n = 185), or baseline and serial spectral-domain OCT ( n = 180) were assessed. Results: Several ceramides, including hexosylceramides, lactosylceramides, and dihydroceramides, were altered in PwMS compared with HCs. Higher levels of Cer16:0 were associated with higher odds of EDSS worsening at 5 years in univariable (odds ratio (OR) = 3.84, 95% confidence interval (CI) = 1.41–10.43) and multivariable analyses accounting for age, sex, and race (OR = 2.97, 95% CI = 1.03–8.59). Each 1 ng/mL higher concentration of Hex-Cer22:0 and DH-HexCer22:0 was associated with accelerated rates (μm/year) of ganglion cell + inner plexiform layer (–0.138 ± 0.053, p = 0.01; –0.158 ± 0.053, p = 0.003, respectively) and peripapillary retinal nerve fiber layer thinning (–0.305 ± 0.107, p = 0.004; –0.358 ± 0.106, p = 0.001, respectively). Conclusion: Ceramide levels are altered in PwMS and may be associated with retinal neurodegeneration and physical disability.
Evidence of subclinical quantitative retinal layer abnormalities in AQP4-IgG seropositive NMOSD
Authors: Filippatou Angeliki G , Vasileiou Eleni S , He Yufan , Fitzgerald Kathryn C , Kalaitzidis Grigorios , Lambe Jeffrey , Mealy Maureen A , Levy Michael , Liu Yihao , Prince Jerry L , Mowry Ellen M , Saidha Shiv , Calabresi Peter A , Sotirchos Elias S 
Published: December 2020

Background: Prior studies have suggested that subclinical retinal abnormalities may be present in aquaporin-4 immunoglobulin G (AQP4-IgG) seropositive neuromyelitis optica spectrum disorder (NMOSD), in the absence of a clinical history of optic neuritis (ON). Objective: Our aim was to compare retinal layer thicknesses at the fovea and surrounding macula between AQP4-IgG+ NMOSD eyes without a history of ON (AQP4-nonON) and healthy controls (HC). Methods: In this single-center cross-sectional study, 83 AQP4-nonON and 154 HC eyes were studied with spectral-domain optical coherence tomography (OCT). Results: Total foveal thickness did not differ between AQP4-nonON and HC eyes. AQP4-nonON eyes exhibited lower outer nuclear layer (ONL) and inner photoreceptor segment (IS) thickness at the fovea (ONL: −4.01 ± 2.03 μm, p = 0.049; IS: −0.32 ± 0.14 μm, p = 0.029) and surrounding macula (ONL: −1.98 ± 0.95 μm, p = 0.037; IS: −0.16 ± 0.07 μm, p = 0.023), compared to HC. Macular retinal nerve fiber layer (RNFL: −1.34 ± 0.51 μm, p = 0.009) and ganglion cell + inner plexiform layer (GCIPL: −2.44 ± 0.93 μm, p = 0.009) thicknesses were also lower in AQP4-nonON compared to HC eyes. Results were similar in sensitivity analyses restricted to AQP4-IgG+ patients who had never experienced ON in either eye. Conclusions: AQP4-nonON eyes exhibit evidence of subclinical retinal ganglion cell neuronal and axonal loss, as well as structural evidence of photoreceptor layer involvement. These findings support that subclinical anterior visual pathway involvement may occur in AQP4-IgG+ NMOSD.