bluuebunny/crossref_metadata_2025_split huggingface dataset:
Participação e Destinação de Terras da União para habitação de interesse social: o que se aprendeu com a luta e o que mudou no território?
Authors: Freitas Urânia Flores da Cruz 
Published: June 2020

Este ensaio busca refletir sobre a política pública urbana no Brasil, com particular atenção às ações do governo, após a criação do Estatuto das Cidades (2003) e dos Grupos de Trabalho da Secretaria do Patrimônio da União (SPU) (2008), com maior ênfase para o período compreendido entre 2008 e 2010. Do ponto de vista das categorias de análise utilizadas, destacam-se: as concepções de território, de habitação de interesse social, de cidade, bem como a participação dos atores envolvidos nas ações da própria SPU. Além disto, foram problematizadas as diferentes percepções dos atores em relação às ações de regularização fundiária; a destinação de imóveis públicos para Habitação de Interesse Social (HIS); e as estratégias para viabilizar o controle social por parte da sociedade civil. As conclusões apontam para as dimensões da aprendizagem em tais experiências.
Clinical and molecular characteristics of Chinese non‐small cell lung cancer patients with ERBB2 transmembrane domain mutations
Authors: Fan Yun , Qiu Jinrong , Yu Ruoying , Cao Ran , Chen Xiaoxi , Ou Qiuxiang , Wu Xue , Shao Yang W. , Nagasaka Misako , Zhang Jiexia , Ou Sai‐Hong Ignatius 
Published: June 2020

Transmembrane domain (TMD) mutations of ERBB2 have previously been reported in lung cancer patients in addition to well‐studied kinase domain (KD) mutations, which may stabilize ERBB2 heterodimerization with other EGFR family members and favor a kinase active conformation. However, the frequency and clinical significance of ERBB2 TMD mutations in Chinese population is unknown. We prospectively analyzed the next‐generation sequencing data of 34 368 Chinese lung cancer patients with different sample types, including tumor tissue, plasma, cerebrospinal fluid, and pleural effusion. Patients' clinical characteristics and treatment history were retrieved from the database for further evaluation. Our findings show that ERBB2 V659/G660 mutations were detected at a frequency of 0.13% (45/34 368), of which the most frequent was V659D/E (88.9%), with a trend in nonsmokers and male. Moreover, 18% of patients (8/45) showed EGFR and/or ERBB2 amplification, whereas nine patients presented EGFR L858R or exon19 deletion. Interestingly, novel ERBB3 TMD mutation I646R was found coexisting in three patients with ERBB2 V659D and one patient with ERBB2 G660D, which might influence its heterodimerization with ERBB2 and further activate ERBB2. Four ERBB2 TMD mutation‐positive patients received afatinib monotherapy or combination therapy, but showed variable responses. One patient with V659E responded well to ERBB2 inhibitor lapatinib plus capecitabine as well as subsequent afatinib treatment upon progression. Our study provides valuable insights into the distribution of ERBB2 TMD mutations by employing the largest Asian lung cancer cohort thus far. Patients with ERBB2 TMD mutations who received afatinib, a pan‐ERBB inhibitor, demonstrated mixed responses, posing the urgent need to develop more effective therapeutic strategy for patients who carry ERBB2 TMD mutations.
WDCM Underpins the Networking of Microbial Resource Centers
Authors: Wu Linhuan , Ma Juncai , Sugawara Hideaki 
Published: June 2020

Abstract
The World Data Centre for Microorganisms (WDCM) with more than 50 years history aims to provide comprehensive data platforms for microbial resources and their integrated data services by fully utilizing involving information technologies for microbial resource centers and microbiologists all over the world. Currently, WDCM is maintaining a network consisting of several databases for 776 microbial resources center from 76 countries and regions. CCINFO (Culture Collections Information Worldwide) provides registration and metadata information for global culture collections. The availability of the taxonomic type strains of prokaryote species is searchable among these registered culture collections constructing infrastructure based on the International Code of Prokaryote Systematics. Furthermore, the GCM (Global Catalogue of Microorganism) integrates and shares strain basis catalogue information from more than 127 culture collections. Utilizing this strain catalogue information, the ABC (Analyzer of Bio‐resource Citation) performs data mining from publications, patents, nucleotide sequences, and genomes from public data sources to form a knowledge base. To host the rapidly increasing metagenomics data, WDCM established the gcMeta platform which features a database management system for archiving and publishing metagenomics data in a standardized way. Recently, WDCM established cooperation with the International Journal of Systematic and Evolutionary Microbiology and Bergey's Manual Trust to provide free genome sequencing for type strains, which is part of the GCM 2.0 10K type strain sequencing project to complete current genomic gaps for the validly published prokaryotic and fungal species enabling genome sequence comparison including DNA–DNA hybridization for new species candidates with already‐established species.
Desulfonatronaceae
Authors: Galushko Alexander , Kuever Jan 
Published: June 2020

Abstract

De.sul.fo.na.tro.na.ce'ae. N.L. neut. n.
Desulfonatronum
, type genus of the family; suff. ‐
aceae
, ending to denote a family; N.L. fem. pl. n.
Desulfonatronaceae
, the family of
Desulfonatronum
.

Desulfobacterota / Desulfovibrionia / Desulfovibrionales / Desulfonatronaceae

Cells are vibrio shaped, which occur singly or in pairs. Gram‐stain‐negative. Endospores are not observed. Motile. Strict anaerobes with a respiratory and a fermentative type of metabolism. Chemolithotrophs with variations for auto‐, mixo‐, and heterotrophy: source of anabolic carbon may derive from CO
3
2−
and HCO
3
−
only, CO
3
2−
+HCO
3
−
+ acetate, or yeast extract. Chemolithoautotrophic growth is achieved via the anaerobic C
1
‐pathway (carbon monoxide dehydrogenase or Wood–Ljungdahl pathway). Species with chemoheterotrophic metabolism can use H
2
and formate as electron donors in the presence of acetate or yeast extract. Chemoorganotrophs with ability to use cytochrome
c
and MK‐6 for respiration and in some species for fermentation. Organic compounds are incompletely oxidized to acetate. All species use sulfate, sulfite, and thiosulfate as terminal electron acceptors, which are reduced to sulfide. Most members can grow by disproportionation of oxidized sulfur compounds. Moderately salt tolerant, obligately alkaliphilic or alkali tolerant; obligately depend on CO
3
2−
and Na
+
; pH optima are within the range of 8.0–10.0. Mesophilic. The major menaquinone is MK‐6 (determined in two out of nine species of the type genus of the family). The family currently accommodates a single genus
Desulfonatronum
. Members of this family are found exclusively in alkaline habitats.

DNA G + C content (mol%)
: 48.8–59.3 (genome, LC,
T
m
).

Type genus
:
Desulfonatronum
Pikuta et al. 1998, VL66.
Methanothermus
Authors: Akinyemi Taiwo , Shao Nana , Whitman William B. 
Published: June 2020

AbstractMe.tha.no.ther'mus. N.L. neut. n.methanummethane; Gr. fem. n.thermeheat; N.L. masc. n.Methanothermusmethane (‐producing) thermophile.Euryarchaeota / Methanobacteria / Methanobacteriales / Methanothermaceae / MethanothermusStraight to slightly curved nonmotile rods, usually 0.3–0.4 μm in diameter and 1–5 μm in length, occurring singly, in short chains and large clusters. The cell envelope consists of an inner layer of pseudomurein and an outer S‐layer of protein subunits. Stains Gram‐positive. Strictly anaerobic. Optimum temperature is 80–88°C; maximum, 97°C; minimum, 55–60°C. Chemolithotrophic, growing on H2and CO2with methane as the final product. Formate, acetate, methanol, and methylamines cannot serve as substrates. Large amounts of H2S are formed in the presence of elemental sulfur, H2, and CO2. Sulfur granules attached to the cells are visible. The genome sequence ofMethanothermus fervidusV24S has been determined.DNA G + C content (mol%): 31.6–33 (genome, LC).Type species:Methanothermus fervidusStetter et al. 1981, VL8.
Hyphomonas
Authors: Abraham Wolf‐Rainer 
Published: June 2020

Abstract

Hy.pho.mo'nas
. Gr. neut. n.
hyphos
filament; Gr. fem. n.
monas
a unit, monad; N.L. fem. n.
Hyphomonas
hypha bearing unit.

Proteobacteria / Alphaproteobacteria / Rhodobacterales / Hyphomonadaceae / Hyphomonas

Rod‐shaped to oval cells measure 0.5–1.0 μm × 1.0–3.0 μm. Species have a biphasic life cycle and generate a single polar prosthecum. Cell division occurs by budding. Buds are produced at tips of polar prostheca, which are 0.2–0.3 μm in diameter and one to five times the length of the cell body. Young daughter cells are oval to pear shaped, lack prostheca, and are smaller than the mother cell. Motile by means of a single polar to lateral flagellum. Pleomorphic, Gram‐negative, not acid‐fast, aerobic, non‐spore‐forming, and chemoorganotrophic. Species catabolize amino acids or tricarboxylic acid cycle intermediates for energy and growth. All strains are catalase‐ and oxidase‐positive, nonproteolytic, and nonsaccharolytic. Gelatin and starch are not hydrolyzed; no indole formed from tryptophan; no DNase, ornithine decarboxylase, lysine decarboxylase, or coagulase activity. With one exception, all species denitrify. Amino acids are required for heterotrophic growth. Optimal temperature for growth, 22–37°C. Most species have Q‐11 as their major ubiquinone with a significant amount of Q‐10 and minor amounts of Q‐9 and Q‐12.
Hyphomonas jannaschiana
has Q‐10 as its major ubiquinone. The major cellular fatty acid is C
18:1
ω6
c
/ω7
c
; major hydroxy fatty acid is C
12:1
3‐OH. Polar lipids are α‐
d
‐glucopyranosyl diacylglycerol, α‐
d
‐glucuronopyranosyl diacylglycerol, phosphatidyl diacylglycerol, and 1,2‐diacyl‐3‐α‐
d
‐glucuronopyranosyl‐
sn
‐glycerol taurinamide. Members of the genus were isolated from marine habitats. They are primary colonizers of submerged marine surfaces, some species producing dense biofilms.

The genus
Hyphomonas
is classified within the family
Hyphomonadaceae
.

DNA G + C content (mol%)
: 58.2–62.5 (genome sequences).

Type species
:
Hyphomonas polymorpha
(ex Pongratz 1957) Moore et al. 1984
VP
.
Lonepinella
Authors: Osawa Ro , Stackebrandt Erko S. , Omaleki Lida , Blackall Patrick J. 
Published: June 2020

Abstract

Lone.pin.el'la
. N.L fem. n.
Lonepinella
named after Lone Pine Koala Sanctuary, a private zoo in Australia.

Proteobacteria / Gammaproteobacteria / Pasteurellales / Pasteurellaceae / Lonepinella

Lonepinella
is a genus within the family
Pasteurellaceae
. Members of the genus
Lonepinella
are Gram‐negative, facultatively anaerobic, nonmotile cells that are coccoidal, or short to extremely filamentous and rod‐shaped. Neither X nor V factor is required for growth. No growth occurs under 15°C or over 40°C and optimum temperature is 37°C. Indole is produced and urea is not hydrolyzed. Gallic acid is produced from tannic acid (tannase positive), and gallic acid is decarboxylated to pyrogallol. The catalase reaction is negative. Reports differ on oxidase activity, possibly due to different detection methods. Acid, but not gas, is produced from
d
‐glucose and some other carbohydrates. The genus is part of the normal intestinal flora of the koala and has been suggested to be a marker for a healthy gut microbiome. Members of the genus have been found in the oral cavity of koalas and in human wound infections following bites from koalas.

DNA G + C content (mol%)
: 37.5–39.1.

Type species
:
Lonepinella koalarum
Osawa et al. 1995, VL56.
Sphingopyxis
Authors: Verma Helianthous , Gundawar Krishna , Choksket Stanzin , Korpole Suresh , Lal Rup 
Published: June 2020

Abstract

Sphin.go.py'xis. N.L. neut. n.
sphingosinum
(from Gr. gen. n.
sphingos
, of sphinx, and suff. ‐
ine
) sphingosine; N.L. pref.
sphingo
‐, pertaining to sphingosine; L. fem. n.
pyxis
‐
idis
, box, case, container; N.L. fem. n.
Sphingopyxis
, intended to mean box of sphingolipid‐containing life.

Proteobacteria / Alphaproteobacteria / Sphingomonadales / Sphingomonadaceae / Sphingopyxis

The cells are Gram‐stain‐negative, aerobic, rod shaped, nonsporulating, motile or nonmotile, and may be flagellated or nonflagellated. Excepting a few, most of them are oxidase‐, catalase‐, and DNase‐positive. Most of them are culturable and can easily grow on culture media such as Luria–Bertani, nutrient agar, tryptic soy agar, R2A, and veal infusion agar. Species of the genus
Sphingopyxis
can utilize a wide variety of carbon and nitrogen sources. The major polar lipids observed in
Sphingopyxis
spp. are phosphatidylcholine, phosphatidylethanolamine, phosphatidylglycerol, diphosphatidylglycerol, phosphatidylmonomethylethanolamine, and sphingoglycolipids. The major fatty acids include C
18:1
ω7
c
, C
16:0
, C
17:1
ω
6
c
, and C
14: 0
2‐OH. The major respiratory quinone observed is ubiquinone Q‐10. In most of the species, the major polyamine observed is spermidine with minor amount of spermine. Most of the members grow at moderate temperatures, while some prefer lower temperature for their growth. Growth can be observed in narrow pH range in some (close to pH 7) and wide range in remaining ones. GC content varies from 62.3 to 69.2% across the characterized species of
Sphingopyxis
. Members of this genus can grow in the presence or absence of NaCl which is also variable among members.

DNA G + C content (mol%)
: 62.40–66.44.

Type species
:

Sphingopyxis macrogoltabida

(Takeuchi et al., 2001).
Thiohalospira
Authors: Sorokin Dimitry Y. , Merkel Alexander Y. , Muyzer Gerard 
Published: June 2020

Abstract

Thi.o.ha.lo.spi'ra. Gr. neut. n.
thion
sulfur; Gr. masc. n.
hals, halos
salt of the sea; L. fem. n.
spira
spiral; N.L. fem. n.
Thiohalospira
salt‐loving sulfur spiral.

Proteobacteria / Gammaproteobacteria / “Thiohalospirales” / “Thiohalospiraceae” / Thiohalospira

The genus
Thiohalospira
was originally classified as a member of the family
Ectothiorhodospiraceae
, order
Chromatiales
, within the
Gammaproteobacteria
. It includes obligately aerobic, moderately to extremely halophilic, neutrophilic, or facultatively alkaliphilic chemolithoautotrophic sulfur‐oxidizing bacteria. CO
2
is assimilated via the Calvin–Benson–Bassham cycle. The genus includes two species: the type species
Thiohalospira halophila
, which is extremely halophilic and neutrophilic, and the moderately halophilic and facultatively alkaliphilic
Thiohalospira alkaliphila
.

DNA G + C content (mol%)
65.6 (
T. alkaliphila
,
T
m
)–69.1 (
T. halophila
, genome).

Type species
:
Thiohalospira halophila
Sorokin et al. 2008a
VP
.
Desulfurivibrio
Authors: Sorokin Dimitry Y. , Merkel Alexander Y. 
Published: June 2020

Abstract

De.sul.fu.ri.vib'rio L. pref.
de
from, off, away; L. masc. n.
sulfur
sulfur; N.L. masc. n.
vibrio
that which vibrates; N.L. masc. n.
Desulfurivibrio
vibrio that reduces sulfur compounds.

Desulfobacterota / Desulfobulbia / “Desulfobulbales” / “Desulfurivibrionaceae” / Desulfurivibrio

The genus
Desulfurivibrio
was originally classified as a member of the
Desulfobulbaceae
family in the
Deltaproteobacteria
. Its closest relatives are members of the genus
Desulfobulbus
, which include mostly propionate‐oxidizing sulfate‐reducing bacteria. In contrast,
Desulfirivibrio
is incapable of sulfate or sulfite reduction, and its main metabolic trait is sulfur disproportionation. It is a moderately salt‐tolerant and obligately alkaliphilic sulfidogenic anaerobe isolated from soda lake sediments. The genus includes a single species
Desulfurivibrio alkaliphilus
, which is the type species of the genus.

DNA G + C content (mol%)
: 60.3 (genome).

Type species
:
Desulfurivibrio alkaliphilus
Sorokin et al. 2008, VL123.
Actinomycetospora
Authors: Tamura Tomohiko 
Published: June 2020

AbstractAc.ti.no.my.ce.to.spo'ra. N.L. masc. n.actinomyces ‐etis(from Gr. fem. n.aktis ‐inos, ray, beam and Gr. masc. n.mukês ‐êtos, mushroom or other fungus), an actinomycete; Gr. fem. n.spora, a seed and, in biology, a spore; N.L. fem. n.Actinomycetospora, referring to an actinomycete with spore chains.Actinobacteria / Actinobacteria / Pseudonocardiales / Pseudonocardiaceae / ActinomycetosporaAerobic, Gram‐positive, non‐acid‐fast, and nonmotile actinomycetes. Substrate mycelium fragments into rod‐shaped elements or not. Short spore chains are generally formed directly on the substrate mycelium, while sporangia may be formed directly on the substrate hyphae. Substrate mycelium fragments into rod‐shaped elements, while some members do not exhibit hyphal fragmentation. The cell wall containsmeso‐diaminopimelic acid. Whole‐cell hydrolysates contain arabinose and galactose (cell‐wall chemotype IV). Phosphatidylcholine and phosphatidylethanolamine are the diagnostic phospholipids. The predominant menaquinone is MK‐8(H4). The major cellular fatty acids are iso‐C16:0, C16:1ω7c/iso‐C15:02‐OH, C16:0, and/or iso‐C15:0. The genus belongs to the familyPseudonocardiaceae. Comparative analyses of the 16S rRNA gene sequence showed that its closest related taxon is the genusPseudonocardia.DNA G+C content (mol%): 69–74.Type species:Actinomycetospora chiangmaiensisJiang et al. 2008VP.
Haloechinothrix
Authors: Salam Nimaichand , Asem Mipeshwaree Devi , Jiao Jian‐Yu , Li Wen‐Jun 
Published: June 2020

Abstract

Ha.lo.e.chi'no.thrix. Gr. masc. n.
hals, halos
salt; Gr. masc. n.
echinos
hedgehog; Gr. fem. n.
thrix
hair; N.L. fem. n.
Haloechinothrix
halophilic, hedgehog‐like filament, referring to halophilic filamentous actinomycetes with spiny aerial mycelium.

Actinobacteria / Actinobacteria / Pseudonocardiales / Pseudonocardiaceae / Haloechinothrix

The genus
Haloechinothrix
is classified as a member of the family
Pseudonocardiaceae
, order
Pseudonocardiales
, in the phylum
Actinobacteria
. Phylogenetically, the genus is closely related to the genera
Amycolatopsis
,
Prauserella
,
Saccharomonospora
,
Sciscionella
,
Tamaricihabitans
, and
Thermocrispum
.
Gram‐positive
, aerobic and moderately halophilic actinobacteria. Forms
extensive substrate mycelium
, which on maturity fragments into rod‐like elements. Aerial mycelium is formed with either spiny structures or long chains of spore‐like structures. Chemotaxonomic features of the genus
Haloechinothrix
include
meso
‐diaminopimelic acid as the diagnostic diamino acid; MK‐8(H
4
) as the predominant menaquinone; diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylglycerol, phosphatidylinositol, and phosphatidylinositol mannosides as the polar lipid profiles; and iso‐C
16:0
, C
16:0
, and summed feature 4 (C
16:1
ω7
c
and/or iso‐C
15:0
2‐OH) as the major components of the fatty acids.

DNA G + C content (%)
: 67.8–68.7 (genome).

DNA G + C content (mol%)
: 66.1–68.1 (HPLC).

Type species
:
Haloechinothrix alba
Tang et al. 2010b
VP
.
Yimella
Authors: Narsing Rao Manik Prabhu , Jiao Jian‐Yu , Li Wen‐Jun 
Published: June 2020

Abstract

Yi.mel'la. L. fem. dim. suff. ‐
ella
; N.L. fem. dim. n.
Yimella
arbitrary name formed from the acronym of Yunnan Institute of Microbiology, YIM, where the first taxonomic studies of this taxon were performed.

Actinobacteria / Actinobacteria / Micrococcales / Dermacoccaceae / Yimella

The genus
Yimella
is classified within the family
Dermacoccaceae
, order
Micrococcales
, and class
Actinobacteria
. Phylogenetically, strains of this genus fall within the radius of the suborder
Micrococcineae
, sharing 16S rRNA gene sequence similarity values of 93.1–95.9% with members of the genera
Dermacoccus
,
Demetria
, and
Kytococcus
. Cells are nonmotile cocci to rod shape, that stain Gram‐positive. Cells are aerobic and facultatively anaerobic. Strains grow at pH ranging 5.0–9.0, temperature ranging 20–45°C, NaCl ranging 0–9% (w/v). The peptidoglycan is type A4α. The predominant menaquinone is MK‐8(H
4
). The cell‐wall sugars are galactose, fucose, mannose, ribose, rhamnose, and glucose. The polar lipids are diphosphatidylglycerol, phosphatidylglycerol, phosphatidylinositol, glucosamine‐containing phospholipid, phosphatidylinositol mannoside, and unidentified phospholipids and polar lipids.

DNA G + C content (mol%)
: 65.6–65.8 (HPLC).

Type species
:
Yimella lutea
Tang et al. 2010
VP
.
Bibersteinia
Authors: Blackall Patrick J. 
Published: June 2020

Abstract

Bi.ber.stei'ni.a. N.L. fem. n
. Bibersteinia
bacterial genus named after Ernst L. Biberstein, who did much of the early characterization work on this organism, including the creation of the serotyping scheme and some of the earliest DNA–DNA relatedness studies that indicated the unique nature of this taxon.

Proteobacteria / Gammaproteobacteria / Pasteurellales / Pasteurellaceae / Bibersteinia

Bibersteina
is a genus within the family
Pasteurellaceae
. Members of this genus are Gram‐negative, nonmotile, rod‐shaped, or pleomorphic cells occurring singly and in pairs or short chains. Most isolates are hemolytic on sheep blood agar and are CAMP‐positive. Growth is mesophilic and facultatively anaerobic or microaerophilic. Nitrate is reduced without gas production. The reaction in Hugh–Leifson medium with (+)‐
d
‐glucose is fermentative without gas production. Variable reactions have been reported for the catalase and oxidase tests. Members of this genus have been associated with systemic infections in lambs and adult sheep and pneumonia in domestic sheep. The role of the organism as a cause of disease in cattle and in wild sheep, particularly bighorn sheep (
Ovis canadensis
), is controversial with reports of the organism being part of the normal flora and other reports linking the organism to disease.

DNA G + C content (mol%)
: 42.6% (
T
m
).

Type species
:
Bibersteinia trehalosi
Blackall et al. 2007
VP
.
Compartment‐model for the simulation of the separation performance of stirred liquid–liquid‐extraction columns
Authors: Weber Benedikt , Jupke Andreas 
Published: June 2020

AbstractFor detailed simulation and evaluation of stirred extraction columns a CFD based compartment‐model was developed. Instead of simulating all effects in a computational expensive PBE‐CFD‐model, the velocity field calculation of the continuous phase is decoupled from the calculation of the dispersed phase (one‐way coupling). In CFD only the continuous phase is simulated and the resulting velocity profile is used in the compartment‐model to simulate the drop movement, coalescence, breakage and mass transfer for a representative number of drops (Monte‐Carlo Method). This decoupling has a major impact on the calculated fluid‐dynamics. Thus, the velocity profile of the CFD results is modified in the model to account for phase interaction. The compartment‐model is applied for the simulation of a Kühni extraction column with the system toluene/water/acetone. The simulation results, namely holdup, drop size and concentration profiles over the column height, are in good agreement with experiments for different loads and different stirrer speeds.
Ectrodactyly‐ectodermal dysplasia‐clefting syndrome presenting with bilateral choanal atresia and rectal stenosis
Authors: Childs Alexandra J. , Mabin David C. , Turnpenny Peter D. 
Published: June 2020

AbstractWe present the case of a male who shortly after birth developed acute respiratory distress due to bilateral choanal atresia, following which he was found to have rectal stenosis. Genetic testing for CHARGE syndrome was negative, but whole genome sequencing identified heterozygosity for a pathogenic missense variant in TP63 (c.727C > T, p.(Arg243Trp). He also has partial cutaneous syndactyly of the third and fourth fingers of the right hand, and bilateral lacrimal duct stenosis/aplasia. A later maxillofacial review identified a palpable submucousal cleft and his scalp hair is blond and slightly sparse. Choanal atresia and rectal stenosis are recognized features of ectrodactyly‐ectodermal dysplasia‐clefting syndrome, but we believe this is the first report of a case presenting with these features in the absence of the cardinal features.