bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of recurrent nasopharyngeal carcinoma patients treated with endoscopic nasopharyngectomy: a meta‐analysis
Authors: Yang Jingyi , Song Xiaole , Sun Xicai , Liu Quan , Hu Li , Yu Hongmeng , Wang Dehui 
Published: May 2020

BackgroundRecurrent nasopharyngeal carcinoma (rNPC) is mainly managed with re‐irradiation or salvage surgery. Endoscopic resection is generally considered as the preferred surgical treatment, whereas a standard treatment modality has yet to be established. This article is aimed to summarize the treatment outcomes of endoscopic rNPC resection.MethodsMajor medical databases including PubMed, EMBASE, Cochrane Central Library, Web of Science, and 2 major Chinese databases, CNKI and Wanfang, were searched for studies on endoscopic rNPC resection. Main characteristics of study and outcomes of interest were retrieved from articles meeting the selection criteria for meta‐analysis.ResultsA total of 761 articles were identified through the initial systematic research. The combined 1‐year, 2‐year, and 5‐year overall survival (OS) rates were 97%, 92%, and 73% with random effect model, respectively. The combined 2‐year and 5‐year disease‐free survival (DFS) rates were 81% and 62%, respectively. Meta‐regression analysis showed that high recurrent tumor (rT) stage (rT3 to rT4) case proportion was a correlative factor of heterogeneity. Combined 2‐year OS rate in rT1, rT2, rT3, and rT4 patients were 100%, 87%, 78%, and 38%, respectively. Combined 2‐year DFS rate in rT1 and rT2 patients were and 96% and 86%, respectively.ConclusionThe combined OS and DFS rates of rNPC patients treated with endoscopic nasopharyngectomy were summarized and reported in our study. This meta‐analysis indicated that endoscopic nasopharyngectomy has comparable and possibly better treatment outcomes than intensity‐modulated radiotherapy (IMRT). Therefore, the result of our study indicated that randomized controlled trials (RCTs) are needed in rNPC patients to compare treatment outcomes of endoscopic nasopharyngectomy vs IMRT.
Molecular Spring‐like Triple‐Helix Coordination Polymers as Dual‐Stress and Thermally Responsive Crystalline Metal–Organic Materials
Authors: Mei Lei , An Shu‐wen , Hu Kong‐qiu , Wang Lin , Yu Ji‐pan , Huang Zhi‐wei , Kong Xiang‐he , Xia Chuan‐qin , Chai Zhi‐fang , Shi Wei‐qun 
Published: May 2020

AbstractElastic metal–organic materials (MOMs) capable of multiple stimuli‐responsiveness based on dual‐stress and thermally responsive triple‐helix coordination polymers are presented. The strong metal‐coordination linkage and the flexibility of organic linkers in these MOMs, rather than the 4 Å stacking interactions observed in organic crystals, causes the helical chain to act like a molecular spring and thus accounts for their macroscopic elasticity. The thermosalient effect of elastic MOMs is reported for the first time. Crystal structure analyses at different temperatures reveal that this thermoresponsiveness is achieved by adaptive regulation of the triple‐helix chains by fine‐tuning the opening angle of flexible V‐shaped organic linkers and rotation of its lateral conjugated groups to resist possible expansion, thus demonstrating the vital role of adaptive reorganization of triple‐helix metal–organic chains as a molecular spring‐like motif in crystal jumping.
Revisiting the Polymerization of Diphenylacetylenes with Tungsten(VI) Chloride and Tetraphenyltin: An Alternative Mechanism by a Metathesis Catalytic System
Authors: Miyairi Mami , Taniguchi Tsuyoshi , Nishimura Tatsuya , Maeda Katsuhiro 
Published: May 2020

AbstractAn alternative reaction mechanism of the polymerization of diphenylacetylelnes using a catalytic system composed of tungsten(VI) chloride and tetraphenyltin has been proposed through the optimization of reaction conditions and investigation of the effect of the electronic nature of diphenylacetylene monomers on the polymerizability. The detailed structures of the polymers have been suggested by mass spectrometric analysis of the obtained polymers and oligomers, which suggested that a phenyl group of tetraphenyltin has been introduced to an initiating end of the polymer chain. Mass spectrometric analysis also provided information about the termination processes of the polymerization. The experimental results strongly suggested that the polymerization of diphenylacetylenes using tungsten(VI) chloride and tetraphenyltin proceeds through a migratory insertion mechanism rather than the long‐accepted metathesis mechanism.
Silica‐Grafted Tris(neopentyl)aluminum: A Monomeric Aluminum Solid Co‐catalyst for Efficient Nickel‐Catalyzed Ethene Dimerization
Authors: Moroz Ilia B. , Florian Pierre , Viger‐Gravel Jasmine , Gordon Christopher P. , Lesage Anne , Copéret Christophe 
Published: May 2020

AbstractA silica‐supported monomeric alkylaluminum co‐catalyst was prepared via surface organometallic chemistry by contacting tris(neopentyl)aluminum and partially dehydroxylated silica. This system, fully characterized by solid‐state 27Al NMR spectroscopy augmented by computational studies, efficiently activates (nBu3P)2NiCl2 towards dimerization of ethene, demonstrating comparable activity to previously reported dimeric diethylaluminum chloride supported on silica. Three types of aluminum surface species have been identified: monografted tetracoordinated Al species as well as two types of bisgrafted Al species—tetra‐ and pentacoordinated. Of them, only the monografted Al species is proposed to be able to activate the (nBu3P)2NiCl2 complex and generate the active cationic species.
Partially Pyrolyzed Binary Metal–Organic Framework Nanosheets for Efficient Electrochemical Hydrogen Peroxide Synthesis
Authors: Wang Mengjun , Zhang Nan , Feng Yonggang , Hu Zhiwei , Shao Qi , Huang Xiaoqing 
Published: May 2020

AbstractHerein, we developed a partially controlled pyrolysis strategy to create evenly distributed NiO nanoparticles within NiFe‐MOF nanosheets (MOF NSs) for electrochemical synthesis of H2O2 by a two‐electron oxygen reduction reaction (ORR). The elemental Ni can be partially transformed to NiO and uniformly distributed on the surface of the MOF NSs, which is crucial for the formation of the particular structure. The optimized MOF NSs‐300 exhibits the highest activity for ORR with near‐zero overpotential and excellent H2O2 selectivity (ca. 99 %) in 0.1 m KOH solution. A high‐yield H2O2 production rate of 6.5 mol gcat−1 h−1 has also been achieved by MOF NSs‐300 in 0.1 m KOH and at 0.6 V (vs. RHE). In contrast to completely pyrolyzed products, the enhanced catalytic activities of partially pyrolyzed MOF NSs‐300 originates mainly from the retained MOF structure and the newly generated NiO nanoparticles, forming the coordinatively unsaturated Ni atoms and tuning the performance towards electrochemical H2O2 synthesis.
Nickel‐Mediated Trifluoromethylation of Phenol Derivatives by Aryl C−O Bond Activation
Authors: Hu Wei‐Qiang , Pan Shen , Xu Xiu‐Hua , Vicic David A. , Qing Feng‐Ling 
Published: May 2020

AbstractThe increasing pharmaceutical importance of trifluoromethylarenes has stimulated the development of more efficient trifluoromethylation reactions. Tremendous efforts have focused on copper‐ and palladium‐mediated/catalyzed trifluoromethylation of aryl halides. In contrast, no general method exists for the conversion of widely available inert electrophiles, such as phenol derivatives, into the corresponding trifluoromethylated arenes. Reported herein is a practical nickel‐mediated trifluoromethylation of phenol derivatives with readily available trimethyl(trifluoromethyl)silane (TMSCF3). The strategy relies on PMe3‐promoted oxidative addition and transmetalation, and CCl3CN‐induced reductive elimination. The broad utility of this transformation has been demonstrated through the direct incorporation of trifluoromethyl into aromatic and heteroaromatic systems, including biorelevant compounds.
Overriding Intrinsic Reactivity in Aliphatic C−H Oxidation: Preferential C3/C4 Oxidation of Aliphatic Ammonium Substrates
Authors: Knezevic Melina , Heilmann Michael , Piccini Giovanni Maria , Tiefenbacher Konrad 
Published: May 2020

AbstractThe site‐selective C−H oxidation of unactivated positions in aliphatic ammonium chains poses a tremendous synthetic challenge, for which a solution has not yet been found. Here, we report the preferential oxidation of the strongly deactivated C3/C4 positions of aliphatic ammonium substrates by employing a novel supramolecular catalyst. This chimeric catalyst was synthesized by linking the well‐explored catalytic moiety Fe(pdp) to an alkyl ammonium binding molecular tweezer. The results highlight the vast potential of overriding the intrinsic reactivity in chemical reactions by guiding catalysis using supramolecular host structures that enable a precise orientation of the substrates.
What's Hot, What's Not: The Trends of the Past 20 Years in the Chemistry of Odorants
Authors: Armanino Nicolas , Charpentier Julie , Flachsmann Felix , Goeke Andreas , Liniger Marc , Kraft Philip 
Published: May 2020

AbstractThis review is the sequel to the 2000 report on the recent advances in the chemistry of odorants and it summarizes the developments in fragrance chemistry over the past 20 years. Following the olfactory spectrum set out in that report, trendsetting so‐called captive odorants (patent‐protected ingredients unavailable to the market) are presented according to the main odor families: “fruity”, “marine”, “green”, “floral”, “spicy”, “woody”, “amber”, and “musky”. The design of odorants, their chemical synthesis, and their use in modern perfumery are illustrated with prominent examples. Featured are new fruity odorants that provide signature in the top note, as well as precursor technology. In the green domain, focus is on leafy notes and green pear. New benzodioxepines and benzodioxoles have modernized the marine family and required a revision of the existing olfactophore models. The replacement of Lilial and Lyral kept the industry busy in the floral domain with a plethora of new “muguets”. There was continued activity in the domain of rose odorants, especially in the area of rose ketones. Biotechnology became significant, for example, with Clearwood and Ambrofix, and the principal odorants of vetiver oil in the woody family have been found. Fourth and fifth families of musk odorants were also discovered and populated. Thus, new avenues for further explorations into fragrance chemistry have been opened.
Three‐dimensional digital image construction of metaxylem vessels in root tips of Zea mays subsp. mexicana from thin transverse sections
Authors: Miki Yasushi , Saito Susumu , Niki Teruo , Gladish Daniel K. 
Published: May 2020

PremiseYoung plant roots share a common architecture: a central vascular cylinder surrounded by enveloping cylinders of ground and dermal tissue produced by an apical promeristem. Roots with closed apical organization can be studied to explore how ontogeny is managed. The analysis of transverse and longitudinal sections has been the most useful approach for this, but suffers from limitations. We developed a new method that utilizes digital photography of transverse sections and three‐dimensional (3D) computer virtual reconstructions to overcome the limitations of other techniques.MethodsSerial transverse sections of teosinte root tips (Zea mays subsp. mexicana) were used to construct longitudinal images, 3D images, and an animated 3D model. The high‐resolution, high‐contrast, and low‐distortion sectioning method developed previously by the authors enabled high‐quality virtual image construction with the aid of a standard laptop computer.ResultsThe resulting 3D images allowed greater insight into root tissue ontogeny and organization, especially specific cellular structures such as histogen layers, xylem vessels, pericycle, and meristematic initials.DiscussionThis new method has advantages over confocal laser scanning microscopy and magnetic resonance imaging for visualizing anatomy, and includes a procedure to correct for sectioning distortion. An additional advantage of this method, developed to produce better knowledge about the developmental anatomy of procambium in roots, is its applicability to a wide range of anatomical subjects.
Microsatellite marker development in the crop wild relative Linum bienne using genome skimming
Authors: Landoni Beatrice , Viruel Juan , Gómez Rocio , Allaby Robin G. , Brennan Adrian C. , Picó F. Xavier , Pérez‐Barrales Rocio 
Published: May 2020

PremiseNuclear microsatellite markers were developed for Linum bienne, the sister species of the crop L. usitatissimum, to provide molecular genetic tools for the investigation of L. bienne genetic diversity and structure.Methods and ResultsFifty microsatellite loci were identified in L. bienne by means of genome skimming, and 44 loci successfully amplified. Of these, 16 loci evenly spread across the L. usitatissimum reference nuclear genome were used for genotyping six L. bienne populations. Excluding one monomorphic locus, the number of alleles per locus ranged from two to 12. Four out of six populations harbored private alleles. The levels of expected and observed heterozygosity were 0.076 to 0.667 and 0.000 to 1.000, respectively. All 16 loci successfully cross‐amplified in L. usitatissimum.ConclusionsThe 16 microsatellite loci developed here can be used for population genetic studies in L. bienne, and 28 additional loci that successfully amplified are available for further testing.
Design, synthesis, and molecular docking study of new monastrol analogues as kinesin spindle protein inhibitors
Authors: El‐Hamamsy Mervat H. , Sharafeldin Nabaweya A. , El‐Moselhy Tarek F. , Tawfik Haytham O. 
Published: May 2020

AbstractLung, colorectal, and breast cancers are the top three types of cancer by incidence and are responsible for one‐third of the cancer incidence and mortality. A series of 18 3,4‐dihydropyrimidine analogues bearing a 1,2‐methylenedioxybenzene component at position 4 with diverse side chains at positions 5 and 6 was designed and synthesized as inhibitors of the Eg5 kinesin enzyme. Target compounds were screened for their anticancer activity according to the NCI‐USA protocol toward a panel of 60 cancer cell lines. Compounds 12a and 12b displayed the best antiproliferation activity against many cell lines. Interestingly, compound 12a displayed lethal effects against non‐small‐cell lung cancer NCI‐H522 cells (−42.26%) and MDA‐MB‐468 breast cancer cells (−1.10%) at a single‐dose assay concentration of 10−5 M. Compounds 11c, 11d, 11g, 12a–d, 13, 15, and 18a were assayed against the kinesin enzyme, with IC50 values ranging from 1.2 to 18.71 μM, which were more potent compared with monastrol (IC50 = 20 μM). Cell cycle analysis of NCI‐H522 cells treated with compound 12a showed cell cycle arrest at the G2/M phase. Furthermore, the expression levels of active caspase‐3 and ‐9 were measured. A molecular docking study was performed for some demonstrative compounds as well as monastrol docked into the allosteric binding site of the kinesin spindle protein.
Thiol‐Assisted Synthesis of Carbon‐Supported Metal Nanoparticles for Efficient Electrocatalytic CO2 Reduction
Authors: Zhuang Zhihong , Zhang Yicheng , Hu Liang , Ying Hangjun , Han Weiqiang 
Published: May 2020

AbstractThe typical preparation route of carbon‐supported metallic catalyst is complex and uneconomical. Herein, we reported a thiol‐assisted one‐pot method by using 3‐mercaptopropionic acid (MPA) to synthesize carbon‐supported metal nanoparticles catalysts for efficient electrocatalytic reduction of carbon dioxide (CO2RR). We found that the synthesized Au−MPA/C catalyst achieves a maximum CO faradaic efficiency (FE) of 96.2% with its partial current density of −11.4 mA/cm2, which is much higher than that over Au foil or MPA‐free carbon‐supported Au (Au/C). The performance improvement in CO2RR over the catalyst is probably derived from the good dispersion of Au nanoparticles and the surface modification of the catalyst caused by the specific interaction between Au nanoparticles and MPA. This thiol‐assisted method can be also extended to synthesize Ag−MPA/C with enhanced CO2RR performance.
Autonomous smart robot for path predicting and finding in maze based on fuzzy and neuro‐Fuzzy approaches
Authors: Batti Habiba , Ben Jabeur Chiraz , Seddik Hassene 
Published: May 2020

AbstractThe navigation of autonomous mobile robots has in recent times gained interest from many researchers in different areas such as the industrial, agricultural, and military sectors. This paper aims at carefully investigating two advanced types of approaches for guiding a non‐holonomic mobile robot to navigate in an environment area cluttered with static obstacles. Firstly, a Fuzzy logic controller (FLC) was designed, using trapezoidal shape Membership functions (MF's). Secondly, an Adaptive neuro fuzzy inference system (ANFIS) controller was used to optimize the results obtained from trapezoidal fuzzy controller. To validate the feasibility and effectiveness of the proposed models, V‐REP and MATLAB software are used. A comparative evaluation is, then, done on the basis of speed. The simulations results showed that the mobile robot could navigate successfully into maze environment with both proposed approaches but ANFIS controller provided better results in comparison to fuzzy controller.
Twenty‐eight years of business strategy and the environment research: A bibliometric analysis
Authors: Farrukh Muhammad , Meng Fanchen , Wu Yihua , Nawaz Kalsoom 
Published: May 2020

AbstractThe competitive academic climate of all the academic fields, including business strategy, puts great stress to publish. To effectively maneuver the field of business strategy and the environment, all the stakeholders, such as academicians and practitioners, must understand the current position of the theory and practice. A systematic bibliometric analysis of a top tier journal can serve this issue by providing a holistic view of the publications' trends and trajectories. This study analyzes the trend of publication in the Business Strategy and the Environment (BSE) Journal since its inception in 1992 to 2019. The study uses two procedures to analyze the bibliometric data collected from the Scopus database. First, we use different aspects such as citation and publication structure to estimate the evolution of the BSE; second, we use VOS viewer software to visualize the mapping of BSE based on co‐citation, bibliographic coupling (BC), and co‐occurrence (CC). The results show a gradual increase in the citation and publication structure of the BSE. The increase in publications and citations indicates BSE's growing stature as a key academic outlet advancing knowledge in business strategy and environmental sustainability research. This study contributes to the literature by identifying the most influential aspects of the journal, which would help researchers to understand the trends and focus of the BSE.
On the integration of Mathcad capabilities into a mass transfer operations course in Chemical Engineering studies
Authors: Roman Claudia , García‐Morales Moisés 
Published: May 2020

AbstractMass transfer unit operations are of extreme importance to chemical engineers. However, they involve complex and tedious calculations which provoke real fear among the students who end up failing and, sometimes, quitting. The exclusive use of hand calculations in engineering studies is discouraging, old‐fashioned, and a primary source of mistakes. The integration of software packages very much facilitates the calculations and engages the students. Computing skills using the latest technologies are prized by employers and can be critical in a recruitment process. This paper reports an example of the unique capabilities of the Mathcad software for the implementation of more appealing teaching strategies. Unknowns and equations are easily associated with specific process variables and engineering phenomena. Thus, if used conveniently, Mathcad Prime can improve the students’ predisposition to learn.
Plasma protein expression differs between colorectal cancer patients depending on primary tumor location
Authors: Holm Matilda , Joenväärä Sakari , Saraswat Mayank , Tohmola Tiialotta , Ristimäki Ari , Renkonen Risto , Haglund Caj 
Published: May 2020

AbstractColorectal cancer (CRC) includes tumors in the right colon, left colon, and rectum, although they differ significantly from each other in aspects such as prognosis and treatment. Few previous mass spectrometry‐based studies have analyzed differences in protein expression depending on the tumor location. In this study, we have used mass spectrometry‐based proteomics to analyze plasma samples from 83 CRC patients to study if differences in plasma protein expression can be seen depending on primary tumor location (right colon, left colon, or rectum). Differences were studied between the groups both regardless of and according to tumor stage (II or III). Large differences in plasma protein expression were seen, and we found that plasma samples from patients with rectal cancer separated from samples from patients with colon cancer when analyzed by principal component analysis and hierarchical clustering. Samples from patients with cancer in the right and left colon also tended to separate from each other. Pathway analysis discovered canonical pathways involved in lipid metabolism and inflammation to be enriched. This study will help to further define CRC as distinct entities depending on tumor location, as shown by the widespread differences in plasma protein profile and dysregulated pathways.
Uncommon presentation of morphea related to interferon beta in a patient with concomitant multiple sclerosis and chronic hepatitis C: A case report
Authors: Gupta Mrinal , Yamauchi Paul S. , Bagot Martine , Szepietowski Jacek , Bhatia Shibani , Lotti Torello , Goldust Mohamad 
Published: May 2020

AbstractRecombinant interferon beta‐1b is one of the treatment options of multiple sclerosis (MS). Insertional biologics that are used in the treatment of MS may lead to skin adverse effects, for example, morphea.
Paper‐Based Electrochemical Sensors and How to Make Them (Work)
Authors: Mazurkiewicz Wojciech , Podrażka Marta , Jarosińska Elżbieta , Kappalakandy Valapil Karthika , Wiloch Magdalena , Jönsson‐Niedziółka Martin , Witkowska Nery Emilia 
Published: May 2020

AbstractPaper‐based devices are said to be easy to make and use. It is true, if you know how. We hope this Review will help people that are new to the field but also those more experienced who want to add some new functionalities to their systems. Tips and common pitfalls are provided in each section as well as references to recommended reading material. Paper devices have been in development for around two millennia, in one form or the other, and ingenious solutions can be borrowed from the world of paper toys, or closer to electrochemistry paper electronics developed from the 1960’ onwards. Small projects on such systems can become a good practice even in laboratories not working on disposable sensors and low‐cost diagnostics as paper‐based devices are a great way to introduce new students to lab work and teach problem solving. We would also like to show that paper indeed has real life applications and is more than just a good keyword but with the number of publications on the topic, it might not always be easy to distinguish the advances from the background noise.