bluuebunny/crossref_metadata_2025_split huggingface dataset:
Template Based Synthesis of Plasmonic Ag‐modified TiO2/SnO2 Nanotubes with Enhanced Photostability for Efficient Visible‐Light Photocatalytic H2 Evolution and RhB Degradation
Authors: Fakharian‐Qomi Mohammad Javad , Sadeghzadeh‐Attar Abbas 
Published: May 2020

AbstractIn the present study, ternary photocatalysts of Ag‐modified hybrid TiO2/SnO2 nanotube with varied Ag contents were synthesized by the liquid‐phase deposition method. The morphology, crystal structure and optical properties of ternary photocatalysts have been investigated in detail and compared with those of SnO2, TiO2, and TiO2/SnO2 nanotubes. The photocatalytic activity of the products has also been evaluated based on the degradation of Rhodamine B and H2 production under visible‐light irradiation. It was found that photostable 0.4 Ag‐TiO2/SnO2 nanotubes exhibit the highest photocatalytic H2 production rate of 1304.8 μmol.h−1.g−1 with the maximum apparent quantum yield (AQY) of 6.3%. The improvement in H2 evolution rate and photodegradation efficiency can be attributed to the synergetic effect of SnO2 coupling with TiO2 nanotubes and Ag modification, mainly owning to enlarged light absorption region, efficient separation of charge carriers in hybrid nanotubes, and localization of surface plasmon resonance of Ag nanoparticles.
Colorimetric Sensing of Hydrogen Peroxide Using Ionic‐Liquid‐Sensitized Zero‐Valent Copper Nanoparticle (nZVCu)
Authors: Zarif Faiza , Khurshid Shazia , Muhammad Nawshad , Zahid Qureshi Muhammad , Shah Noor S. 
Published: May 2020

AbstractIn this study, a stable ionic liquid (IL) mediated zero‐valent copper nanoparticle (nZVCu), namely IL‐nZVCu, has been evaluated for catalytic properties towards H2O2‐mediated TMB (3, 3’,5,5’‐tetramethylbenzidine) reaction under normal conditions of temperature and pH. The various analytical techniques like Fourier Transform Infrared Spectroscopy (FT‐IR), UV–Vis diffuse reflectance spectroscopy (UV‐Vis DRS), X‐ray powder diffraction (XRD), scanning electron microscope (SEM), Transmission electron microscopy (TEM) and X‐ray photoelectron spectroscopy (XPS) were used to confirm the structure and nano size of nZVCu. The simple protic IL 1‐hydrogen‐3‐methylimidazolium acetate (HmimOAc) with its cation 1‐methylimidazole and anion acetate was synthesized, characterized, and coated on nZVCu to prepared IL‐nZVCu. As a novel mimic peroxidase, IL‐nZVCu could quickly catalyze the oxidation reaction of specific chromogenic substrate TMB, when H2O2 acts as an oxidant, followed by a remarkable color change in the solution measured by UV/Vis Spectrophotometry. The enhanced catalytic activity and significant color change were greatly dependent on the catalyst dosage, the volume of IL taken, incubation time, H2O2 concentration, and TMB concentration. Also, IL‐nZVCu showed no response toward ascorbic acid, cholesterol, dopamine, urea and uric acid. Based on these findings, IL‐nZVCu could be effectively used for visual colorimetric sensing of H2O2 with a limit of detection (LOD) of 44 μM over the dynamic linear range from 40 μM to 1000 μM concentration.
Eu3+, Sm3+ Deep‐Red Phosphors as Novel Materials for White Light‐Emitting Diodes and Simultaneous Performance Enhancement of Organic–Inorganic Perovskite Solar Cells
Authors: Khan Shahid Ullah , Khan Waheed Ullah , Khan Wasim Ullah , Khan Dilfaraz , Saeed Sumbul , Badshah Syed , Ikram Muhammad , Saleh Tawfik A. 
Published: May 2020

AbstractThe luminous efficiency of inorganic white light‐emitting diodes, to be used by the next generation as light initiators, is continuously progressing and is an emerging interest for researchers. However, low color‐rendering index (Ra), high correlated color temperature (CCT), and poor stability limit its wider application. Herein, it is reported that Sm3+‐ and Eu3+‐doped calcium scandate (CaSc2O4 (CSO)) are an emerging deep‐red‐emitting material with promising light absorption, enhanced emission properties, and excellent thermal stability that make it a promising candidate with potential applications in emission display, solid‐state white lighting, and the device performance of perovskite solar cells (PSCs). The average crystal structures of Sm3+‐doped CSO are studied by synchrotron X‐ray data that correspond to an extremely rigid host structure. Samarium ion is incorporated as a sensitizer that enhances the emission intensity up to 30%, with a high color purity of 88.9% with a 6% increment. The impacts of hosting the sensitizer are studied by quantifying the lifetime curves. The CaSc2O4:0.15Eu3+,0.03Sm3+ phosphor offers significant resistance to thermal quenching. The incorporation of lanthanide ion‐doped phosphors CSOE into PSCs is investigated along with their potential applications. The CSOE‐coated PSCs devices exhibit a high current density and a high power conversion efficiency (15.96%) when compared to the uncoated control devices.
Transcranial stimulation in frontotemporal dementia: A randomized, double‐blind, sham‐controlled trial
Authors: Benussi Alberto , Dell'Era Valentina , Cosseddu Maura , Cantoni Valentina , Cotelli Maria Sofia , Cotelli Maria , Manenti Rosa , Benussi Luisa , Brattini Chiara , Alberici Antonella , Borroni Barbara 
Published: May 2020

AbstractIntroductionFrontotemporal dementia (FTD) is a progressive disease for which no curative treatment is currently available. We aimed to determine whether transcranial direct current stimulation (tDCS) can modulate intracortical connectivity and improve cognition in symptomatic FTD patients and presymptomatic FTD subjects.MethodsWe performed a double‐blind, randomized, sham‐controlled trial with anodal tDCS or sham stimulation over the left prefrontal cortex in 70 participants (15 presymptomatic and 55 symptomatic FTD).ResultsWe observed a significant increase of intracortical connectivity (short interval intracortical inhibition and facilitation) and improvement in clinical scores and behavioral disturbances in both symptomatic FTD patients and presymptomatic carriers after real tDCS but not after sham stimulation.DiscussionA 2‐weeks’ treatment with anodal left prefrontal tDCS improves symptoms and restores intracortical inhibitory and excitatory circuits in both symptomatic FTD patients and presymptomatic carriers. tDCS might represent a promising future therapeutic and rehabilitative approach in patients with FTD.
Long non-coding RNAs in cutaneous biology and keratinocyte carcinomas
Authors: Piipponen Minna , Nissinen Liisa , Kähäri Veli-Matti 
Published: May 2020

AbstractLong non-coding RNAs (lncRNAs) are a largely uncharacterized group of non-coding RNAs with diverse regulatory roles in various biological processes. Recent observations have elucidated the functional roles of lncRNAs in cutaneous biology, e.g. in proliferation and differentiation of epidermal keratinocytes and in cutaneous wound repair. Furthermore, the role of lncRNAs in keratinocyte-derived skin cancers is emerging, especially in cutaneous squamous cell carcinoma (cSCC), which presents a significant burden to health care services worldwide and causes high mortality as metastatic disease. Elucidation of the functions of keratinocyte-specific lncRNAs will improve understanding of the molecular pathogenesis of epidermal disorders and skin cancers and can be exploited in development of new diagnostic and therapeutic applications for keratinocyte carcinomas. In this review, we summarize the current evidence of functionally important lncRNAs in cutaneous biology and in keratinocyte carcinomas.
Tumorvakzinierung – therapeutische Vakzinierung gegen Krebs
Authors: Rammensee H.-G. , Löffler M. W. , Walz J. S. , Bokemeyer C. , Haen S. P. , Gouttefangeas C. 
Published: May 2020

ZusammenfassungTumorzellen weisen immer Veränderungen im Vergleich zu normalen Zellen auf. Die Veränderungen können vom Immunsystem erkannt werden, was zur Zerstörung der Tumorzellen durch T‑Zellen führen kann. Der Erfolg der Immuncheckpointinhibition beispielsweise beim malignen Melanom hat dies eindrucksvoll gezeigt. Viele Tumorerkrankungen sprechen jedoch nicht auf eine solche Therapie an. Hier könnte eine Vakzinierung gegen Tumorantigene hilfreich sein. Allerdings waren alle Bestrebungen in den letzten 30 Jahren praktisch erfolglos. Mit den heutigen Kenntnissen besteht jedoch neue Hoffnung.
PHANTOM: Curating GitHub for engineered software projects using time-series clustering
Authors: Pickerill Peter , Jungen Heiko Joshua , Ochodek Mirosław , Maćkowiak Michał , Staron Miroslaw 
Published: May 2020

Abstract
Context
Within the field of Mining Software Repositories, there are numerous methods employed to filter datasets in order to avoid analysing low-quality projects. Unfortunately, the existing filtering methods have not kept up with the growth of existing data sources, such as GitHub, and researchers often rely on quick and dirty techniques to curate datasets.

Objective
The objective of this study is to develop a method capable of filtering large quantities of software projects in a resource-efficient way.

Method
This study follows the Design Science Research (DSR) methodology. The proposed method, PHANTOM, extracts five measures from Git logs. Each measure is transformed into a time-series, which is represented as a feature vector for clustering using the k-means algorithm.

Results
Using the ground truth from a previous study, PHANTOM was shown to be able to rediscover the ground truth on the training dataset, and was able to identify “engineered” projects with up to 0.87 Precision and 0.94 Recall on the validation dataset. PHANTOM downloaded and processed the metadata of 1,786,601 GitHub repositories in 21.5 days using a single personal computer, which is over 33% faster than the previous study which used a computer cluster of 200 nodes. The possibility of applying the method outside of the open-source community was investigated by curating 100 repositories owned by two companies.

Conclusions
It is possible to use an unsupervised approach to identify engineered projects. PHANTOM was shown to be competitive compared to the existing supervised approaches while reducing the hardware requirements by two orders of magnitude.
Orthodontic radiology: development of a clinical practice guideline
Authors: Kapetanović Aldin , Oosterkamp Barbara C. M. , Lamberts Antoon A. , Schols Jan G. J. H. 
Published: May 2020

Abstract
Objectives
Radiographs are considered essential in orthodontics. However, their diagnostic value and indications for use are still uncertain, while exposure to radiation carries health risks. This study aimed to report on the development of a clinical practice guideline on orthodontic radiology.

Methods
A Guideline Development Taskforce was set up. The GRADE methodology was used for development and the RIGHT Statement for reporting of the guideline. We systematically reviewed articles to address the main clinical question: how different types of radiographs contribute to orthodontic diagnosis, treatment planning and post-treatment outcome evaluation. After a literature search and data extraction, we formulated conclusions and assessed the strength of the evidence according to the GRADE method. Both literature conclusions and the most important considerations, such as patient preferences, organizational matters and expert opinions were taken into account to finally issue recommendations.

Results
7 clinical questions focused on orthopantomograms, lateral cephalograms, hand-wrist radiographs, peri-apical radiographs, bitewings, antero-occlusal radiographs, and cone-beam computer tomographic imaging. The literature search lead to 484 unique studies, of which 17 were included in the analysis. The strength of evidence of the conclusions was graded low or very low. We formulated considerations and took them into account when issuing the 13 clinical recommendations to address the clinical questions.

Conclusions
There was a considerable lack of scientific evidence on this topic. Nonetheless, this guideline provides clinicians with a tool for decision-making regarding radiographic records while enhancing patient radiation protection. More research of higher quality is recommended for a future update.
Revolutions in treatment options in gastrointestinal stromal tumours (GISTs): the latest updates
Authors: Farag Sheima , Smith Myles J. , Fotiadis Nicos , Constantinidou Anastasia , Jones Robin L. 
Published: May 2020

Opinion statementThe treatment of advanced GIST is rapidly evolving with the development of novel molecular compounds such as avapritinib and ripretinib, but also promising results have been achieved with cabozantinib in a phase II trial. The availability of over five lines of treatment for patients with advanced GIST is likely to completely shift the current second-line and third-line treatment options, and will also potentially enable a personalised approach to treatment. Imatinib will most likely remain as the first-line treatment of choice for the vast majority of GIST patients. However, for GIST patients with tumours harbouring a D842V mutation in PDGFRA exon 18, avapritinib has shown efficacy and will become first-line therapy for this molecular subgroup. For second- and third-line treatment, results are awaited of a number of clinical trials. However, second-line and further treatment could potentially be tailored depending on secondary mutations found in imatinib-resistant GISTs. As secondary resistance to TKIs remains the biggest challenge in the treatment of GIST and despite negative results with alternating regimens in phase II, combination treatments should be further evaluated to tackle this issue. Moreover, the favourable safety profiles observed with avapritinib and ripretinib suggest that combination treatments are feasible, for instance, combining two TKIs or a TKI with drugs targeting downstream signalling pathways, such as PI3K inhibitors or MEK inhibitors. Finally, in line with further personalisation of treatment in GIST, a multidisciplinary approach is essential, and local treatment options, such as RFA, resection in case of unifocal progression, and radiotherapy, should be considered.
Jeffrey’s insights: Jeffrey Modell Foundation’s global genetic sequencing pilot program to identify specific primary immunodeficiency defects to optimize disease management and treatment
Authors: Quinn Jessica , Modell Vicki , Holle Jennifer , Truty Rebecca , Aradhya Swaroop , Johnson Britt , Orange Jordan , Modell Fred 
Published: May 2020

AbstractPrimary immunodeficiencies (PI) are genetic defects of the immune system that result in chronic and often life-threatening infections and/or life-threatening autoimmunity if not diagnosed and treated. Patients with a suspected PI, but without a genetic diagnosis, commonly undergo a diagnostic odyssey that is costly, time-consuming, and arduous. This delay in diagnosis prevents appropriate disease management and treatment, contributing to prolonged suffering and decreased quality of life. Although next generation sequencing (NGS) can provide these patients with relief from such a diagnostic odyssey, it is often unavailable, mainly due to cost and inaccessibility. In January 2019, the Jeffrey Modell Foundation (JMF) launched a free genetic sequencing pilot program for Jeffrey Modell Centers Network (JMCN) patients clinically diagnosed with an underlying PI. A total of 21 sites within the JMCN were invited to participate. JMF collaborated with Invitae, and testing was comprised of Invitae’s Primary Immunodeficiency Panel, which currently includes 207 genes. A questionnaire was disseminated to each participating physician to evaluate barriers to access to genetic sequencing and changes in disease management and treatment after testing. One hundred fifty-eight patients and 29 family members were tested in this pilot study. Twenty-one percent of patients with a suspected monogenic disorder received a molecular diagnosis, and others received potentially useful diagnostic leads. Based on the results of genetic sequencing, clinical diagnosis was altered in 45% of patients, disease management was altered in 40%, treatment was altered in 36%, and genetic counseling was altered in 62%. The results of this pilot program demonstrate the utility, cost-efficiency, and critical importance of NGS for PI and make the case for broad scale sequence–based diagnostics for PI patients when requested by expert immunologists.
Supera Stent for Management of Occlusive Popliteal Artery Disease: an Indian Experience
Authors: Dalai Sibasankar , Narayana R. V. , Pati Rajesh , Kadali Mrudula , Mazumdar Alok , Akkina Narendranadh , Panda Samir Kumar 
Published: May 2020

Abstract
Introduction
Popliteal artery occlusion is common in elderly, smokers, and patients with diabetes, with globally rising incidence. Angioplasty and stenting are common treatment options available to manage lower limb occlusive diseases. As popliteal artery experiences high biomechanical stress, Supera stent is designed to reduce the risk of stent fractures and for better patency across the knee joint.

Aim & Objectives
The aim of this study is to evaluate the Supera stent in the management of popliteal artery occlusive disease. The objectives of this study are (1) to evaluate the efficacy of Supera stent in the management of popliteal artery occlusive disease and (2) to prove it as a relatively safe to use option.

Material & Methods
Patients who underwent stent implantation in popliteal artery were analyzed with regular/serial follow-up. Critical limb ischemia and intermittent claudication patients were included. Medical records, radiographs, and procedural data were examined. The patients were classified according to Trans-Atlantic Inter Society Consensus II criteria. The femoropopliteal lesions which were classified into TASC B and C categories were included in the study. Stents of 5 mm and 5.5 mm diameter and with various lengths were used to treat all the patients.

Results
A total number of patients with tissue loss and rest pain analyzed were eighty-six and all of them were treated by implanting stents in popliteal artery. In 71.4% of cases, the lesions were found in the proximal segment of the artery. In nearly 95% of cases, technical success was achieved with the use of single stent. The primary and assisted primary patency rates at 24 months were found to be 86.04% and 95.34%, respectively. Notwithstanding the stent placement at a region of high biomechanical stress, there was no case of stent fracture. The limb salvage rate was 100%. The patients who died due to unrelated causes within 90 days of procedure were two.

Conclusion
The present study demonstrated that Supera stent is a safe and effective procedure for treating claudication and limb ischemia due to popliteal artery disease.
The molecular analysis of four coexistent mutations in additional sex combs like 1 (ASXL1) gene in a patient with acute myeloid leukemia
Authors: Leszczyńska Aleksandra , Prejzner Witold , Grzenkowicz-Wydra Jolanta , Bieniaszewska Maria , Zaucha Jan Maciej 
Published: May 2020

AbstractMutations in the additional sex combs like 1 (ASXL1) gene are frequently involved in clonal hematopoiesis and are connected with an increased risk of hematologic cancer. These aberrations are frequently detected in a number of different hematological neoplasms including acute myeloid leukemia (AML). Patients harboring ASXL1 mutations tend to have a poor prognosis and poor response to therapy. Here, we report the coexistence of four different mutations in ASXL1 gene in a patient with AML. Such accumulation of mutations, in this gene, has not been described yet. Our findings suggest that accumulations of mutations in ASXL1 gene may play an important role in the development and/or progression of AML.
Impact of Processing Factors on Quality of Frozen Vegetables and Fruits
Authors: van der Sman R. G. M. 
Published: May 2020

AbstractIn this paper I review the production of frozen vegetables and fruits from a chain perspective. I argue that the final quality of the frozen product still can be improved via (a) optimization of the complete existing production chain towards quality, and/or (b) introduction of some promising novel processing technology. For this optimization, knowledge is required how all processing steps impact the final quality. Hence, first I review physicochemical and biochemical processes underlying the final quality, such as water holding capacity, ice crystal growth and mechanical damage. Subsequently, I review how each individual processing step impacts the final quality via these fundamental physicochemical and biochemical processes. In this review of processing steps, I also review the potential of novel processing technologies. The results of our literature review are summarized via a causal network, linking processing steps, fundamental physicochemical and biochemical processes, and their correlation with final product quality. I conclude that there is room for optimization of the current production chains via matching processing times with time scales of the fundamental physicochemical and biochemical processes. Regarding novel processing technology, it is concluded in general that they are difficult to implement in the context of existing production chains. I do see the potential for novel processing technology combined with process intensification, incorporating the blanching pretreatment—but which involves quite a change of the production chain.
Mental rotation and performance in basketball: effects of self-controlled and externally controlled time constraints on the processing and execution of tactic board instructions with varied orientations
Authors: Krause Daniel , Weigelt Matthias 
Published: May 2020

AbstractPurposeIn sports games, tactical instructions are mostly presented on tactic boards under temporal constraints determined by the length of time outs (e.g., 20–60 s time outs in basketball) and coaches’ instructional behavior. Thus, instructions should be presented in a way that enables fast and errorless information processing. High affordances in visual–spatial transformation (e.g., mental rotation processes) might both impede information processing and decrease execution performance. The aim of this study was to scrutinize the effect of different orientations of visual tactical displays on observation time under self-paced conditions as well as to compare the effects on execution performance to those of externally paced conditions. According to the self-determination theory, self-control over observation time is assumed to increase performance.MethodsIn a mixed-factors design with two factors, 48 participants were instructed to execute a basketball playing pattern, which was presented on a virtual tactic board in one of five different spatial disparities to the players’ on-court perspective. The Self-Paced Group determined the observation time in a self-controlled manner, whereas in the Yoked Group observation times were externally controlled, i.e., the observation time was constrained to match that of the Self-Paced Group..ResultsThe self-controlled time for watching the pattern before execution was significantly shorter and spatial accuracy in pattern execution was significantly higher for low disparity between instruction perspective and on-court perspective. Self-control over observation time did not affect execution accuracy.ConclusionThe orientation effects might be explained by interfering mental rotation processes that are necessary to transform the instructional perspective into the players’ egocentric perspective. According to these results, coaches should align their tactic boards to their players’ on-court viewing perspective.