bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic role of long noncoding RNA CASC11 in cancer patients: A meta-analysis
Authors: Zhang Song , Xu Bo , Zhang Ji-Ling , Liu Shun-Hai , Xiang Xin , Liu Pan 
Published: December 2024

Background:
Long noncoding RNA (lncRNA) is a significant component of the noncoding genome and refers to RNA molecules that exceed 200 nucleotides in length. It plays a crucial role in both promoting and suppressing cancer by regulating the proliferation, invasion, and metastasis of tumor cells. We have found a correlation between cancer susceptibility candidate 11 (CASC11) experssion and tumorigenesis development prognosis in a number of studies on tumors. Hence, this meta-analysis was conducted to further investigate the effects of CASC11 expression on clinicopathological features and outcome. Furthermore, CASC11 can act both as a therapeutic target and a cancer biomarker.

Method:
We conducted a thorough search of PubMed, Embase, Web of Science, and Cochrane Library to identify all eligible studies until September 20, 2023. These studies examined the potential relationship between the expression levels of CASC11 and survival or the range of pathological feature in cancer patients. The impact of CASC11 expression on overall survival (OS) was evaluated using pooled hazard ratios and 95% confidence intervals (CI). The relationship between CASC11 expression and clinicopathological features was assessed through pooled odds ratios and 95% CI.

Results:
A total of 11 studies, involving 660 patients, were examined in this analysis. The results revealed that the overexpression of CASC11 was significantly associated with poor OS (hazard ratios = 2.07, 95%CI = 1.64–2.60) in cancer. Further subgroup analysis demonstrated that the overexpression of CASC11 was consistently linked to poorer OS in diverse types of cancer, including digestive system neoplasm, respiratory neoplasms, and gynecologic tumor.

Conclusion:
Overall, this analysis established a strong correlation between CASC11 expression and tumor prognosis, suggesting its potential as a predictive marker for tumor progression in diverse cancer types.
The effectiveness of care robots in alleviating physical burden and pain for caregivers: Non-randomized prospective interventional study – Preliminary study
Authors: Jung Jae Ik , Jeong Yoo Seok , Kwon Dong Rak 
Published: December 2024

Background:
Caregiver burden significantly affects both patients and caregivers but is often overlooked in clinical practice. Physical and emotional strain on caregivers can compromise the quality of care. Care robots are emerging as solutions to alleviate these burdens by assisting with routine tasks, thereby reducing caregivers’ physical strain and stress. Therefore, a prospective, non-randomized, interventional clinical trial was designed to identify changes in caregivers’ physical activities due to care robot use and explore the associated benefits.

Methods:
Twenty-two caregivers (1 male and 21 female; mean age, 62.05 years) were participated. We analyzed the impact of care robots on reducing physical burden and assessed caregivers’ satisfaction with these robots by examining care activity history, pain levels, muscle activities, and data for each physical care activity (e.g., transfer, reposition, feeding, and toileting), categorizing them based on whether a care robot was used. Care robots that assist in transfer, repositioning, feeding, and toileting activities were used in a clinical trial. Muscle activity was measured during maximum voluntary isometric contraction using electromyography sensors placed on the upper trapezius, biceps brachii, and erector spinae muscles.

Results:
During care robot use, we observed a statistically significant decrease in the distance and number of steps required for assisting with repositioning. However, the caregiving activity time increased when the robots assisted with transfer, feeding, and toileting (P < .001). Pain was significantly reduced during transfer and toileting activities using the care robot (P < .001) as well as during feeding activity (P = .040). Maximum voluntary isometric contraction showed a significant reduction in the upper trapezius, biceps brachii, and erector spinae muscles during the 4 care activities when using the robot, and these findings were consistent across the 3 sessions (P < .001). In the survey, caregivers indicated that “transfer-assisting” care robots were the most needed (15 respondents, 68.2%).

Conclusion:
In this study, we demonstrated that employing care robots can aid in mitigating muscle overuse among caregivers, potentially alleviating pain due to musculoskeletal conditions.
Quantification of gait characteristics and muscle activation in patients with chronic ankle instability during walking on sand: A randomized crossover trial
Authors: Lee Geon Woo , Lee Juseong , Shin Seung Woo , Kim Junghoon 
Published: December 2024

Background:
Limited evidence exists regarding the movement control patterns of individuals with chronic ankle instability (CAI) during sand walking. This study aimed to analyze gait characteristics and muscle activation in patients with CAI while walking on sand.

Methods:
This study recruited 30 participants, including 15 patients with CAI and 15 healthy controls. Patients with CAI were selected based on having experienced at least a lateral ankle sprain within 12 months before recruitment. They also had to scoring ≤ 27 on the Cumberland ankle instability tool. This study was conducted using a randomized crossover trial. All participants were asked to walk three times each at their natural speed on both sand and paving blocks for a distance of 50m. There was at least a week between each trial.

Results:
The lower limb gait kinematics, spatiotemporal, and muscle activity parameters while walking on sand and paving blocks were compared between both groups. Significant differences in knee angle were observed between 60.83% and 75.34% of the gait cycle during walking on sand in the patients with CAI. Regarding spatiotemporal parameters, cadence (P = .001) and stride length (P = .049) showed significant differences as the main effect. In the CAI group, the recruitment threshold for the peroneus longus muscle was significantly lower during walking on sand than on paving blocks (P < .001). In contrast, the motor unit action potential (MUAP) was significantly higher (P < .001). For the tibialis anterior muscle, the recruitment threshold and number of motor units were significantly lower during walking on sand than on paving blocks (P = .006 and P = .003, respectively), and the MUAP was significantly higher (P < .001). During walking on sand, patients with CAI exhibited increased knee flexion angle, stride length, and MUAP, along with decreased cadence and recruitment thresholds.

Conclusion:
These results suggest that sand can influence gait characteristics and muscle activation in patients with CAI. Our findings indicate that gait characteristics and muscle activation changes in patients with CAI could potentially benefit CAI rehabilitation.
Trousseau syndrome-induced cerebral infarction: Two case reports
Authors: Chen Yongzhen , Wan Qiuxia , Li Shanshan , Liu Bo 
Published: December 2024

Rationale:
As a paraneoplastic syndrome, Trousseau syndrome (TS) is a collective term for various thromboembolic events caused by clotting and fibrinolytic abnormalities in patients with tumors, clinically manifesting as venous and arterial thromboembolism, as well as disseminated intravascular coagulation (DIC). The incidence rate of arterial thrombosis in patients with TS is 2% to 5%.

Patient concerns:
This article reports 2 patients with TS-induced cerebral infarction. One patient had been definitively diagnosed with cervical adenosquamous carcinoma (stage IVB) accompanied by metastases to the liver and scapulae on May 18, 2020, and was treated with surgery and chemoradiotherapy. The other patient had received laparoscopic radical surgery for distal gastric cancer on March 5, 2018, and had undergone postoperative chemotherapy.

Diagnoses:
Both current illnesses had a stroke-like onset, and cranial magnetic resonance imaging (MRI) results were in line with cerebral infarction changes. Hematological examination of both patients revealed an obviously increased D-dimer level. The results for Case 2 also indicated deep-venous thrombosis of the right lower extremity. The 2 patients were finally diagnosed with TS, which was ameliorated after anticoagulant (low-molecular-weight heparin [LMWH]) treatment.

Lessons:
Here, the clinical characteristics and treatment of these 2 TS patients are analyzed and the relevant literature is reviewed to improve understanding, diagnosis, and treatment of the disease. Cerebral infarction is the initial symptom in some patients with malignancies. For unexplained multiple cerebral infarctions, we should screen for occult malignancies to facilitate early diagnosis and treatment, as early and accurate identification of the cause of the disease may improve prognosis.
Dysplastic ganglion cell tumor of the right cerebellum: A case report and literature review
Authors: Wang Shilong , Li Jun , Dong Jiangtao , Wang Ganggang , Xu Haoxiang , Zhu Licang , Xu Hui 
Published: December 2024

Rationale:
This study aims to present a case of cerebellar dysplastic ganglioneuroma, which is commonly referred to as Lhermitte–Duclos disease (LDD). Furthermore, the study aims to provide an extensive review of the essential aspects of LDD, thereby providing essential information for its accurate diagnosis and effective treatment.

Patient concerns:
A 54-year-old woman was admitted with symptoms of headache, facial numbness, and a visible cerebellar mass. Imaging studies revealed specific features such as the “tiger stripe sign” on magnetic resonance imaging, including hydrocephalus compression and abnormal vasculature.

Diagnoses:
The diagnosis of LDD was made.

Interventions:
The cerebellar mass was resected via a paracentral approach.

Outcomes:
The patient underwent surgery for a cerebellar dysplastic ganglion cell tumor (WHO grade I), confirmed by postoperative pathology. Despite sub-complete resection with minor residuals, the patient experienced significant improvement in symptoms. A postoperative computed tomography scan revealed a large cavity with frontal lobe hemorrhage. PTEN gene testing was recommended but declined due to financial constraints. The patient was discharged without complications.

Lessons:
LDD presents both benign and tumor characteristics, with a low likelihood of malignancy. Total resection is the recommended treatment, although challenges in complete excision may lead to recurrence. The importance of considering Cowden syndrome and genetic testing, particularly the PTEN gene, in patients with LDD, is emphasized. Long-term follow-up care is crucial for monitoring recurrence and related conditions.
Double-Duty Caregivers’ Satisfaction With Health Care Provider Communication
Authors: Gouveia Jean Marie , Revell Susan Hunter , McCurry Mary K. , Tyo Mirinda Brown 
Published: December 2024

Abstract

Background
Double-duty caregivers are health care professionals caring for family members or friends outside the workplace. While they may communicate frequently with colleagues in their professional role, little is known about communication with health care providers in the caregiving role.

Objective
To measure double-duty caregiver satisfaction when communicating with health care providers and to identify correlates and predictors of satisfaction.

Methods
A cross-sectional, nonexperimental, correlational study was used. Participants included registered nurses who were current or former caregivers of a family member or friend aged 50 or older. Correlation and multiple linear regression analyses were performed to examine the associations between double-duty caregivers’ personal and professional attributes, factors, and satisfaction with communication.

Results
Double-duty caregivers reported above-average satisfaction with communication. Personal beliefs about caring and trust had the highest influence on satisfaction. Stress was associated with lower satisfaction with communication.

Discussion
This study is the first to examine double-duty caregiver satisfaction when communicating with health care providers and associated factors. Health care providers must implement strategies to maximize their acknowledgment of personal beliefs about caring and foster the building of trusting relationships to support colleagues in this role.
Childhood sexual abuse, alcohol problem scores, and race are associated with syphilis incidence in a prospective cohort of young sexual and gender minority adults assigned male at birth
Authors: Xavier Hall Casey D. , Ryan Daniel T. , Hayford Christina , Morgan Ethan , D’Aquila Richard , Mustanski Brian 
Published: December 2024

Abstract

Background
Syphilis rates in the United States have dramatically increased in recent years and are high among young men who have sex with men and transgender women. Yet, few studies have examined a wide-range of risk factors for syphilis incidence prospectively in young sexual and gender minority (YSGM) populations in the U.S. One framework which may have utility in understanding syphilis risk factors is syndemics, which focuses on co-morbid factors and their mutual influence. The current analysis examines demographic, comorbid health and socio-structural risk factors for syphilis in YSGM assigned male at birth including applying a syndemic framework.

Methods
Participants were part of a Chicago-based prospective cohort called RADAR (n = 738). All participants were YSGM. Syphilis cases were identified by serologic screening with a reverse-sequence testing algorithm. Risk factors included demographics, indicators of sexual risk, mental health, substance use, and violence victimization. Syndemic component score was calculated by adding the number of syndemic conditions. Analyses included multivariable logistic regressions.

Results
In multivariable predictive modeling, Black identity, childhood sexual abuse and alcohol problems predicted incident syphilis. Though roughly 37% of participants were indicated as having at least 2 syndemic conditions, the syndemic component did not predict syphilis incidence.

Conclusions
Syphilis incidence is high in this sample of YSGM. Additional research is needed to better understand mechanisms driving associations between childhood sexual abuse and syphilis incidence as well as to develop interventions improve testing and treatment among Black YSGM, YSGM who experience childhood sexual abuse, and YSGM who experience alcohol problems.
Novel predictive tool for Fournier gangrene: Twenty-year experience of a tertiary institute
Authors: Chien Huang-Yi , Liao Chun-Hou , Lin Yu-Hua , Lu Yu-Chuan 
Published: December 2024

Purpose:
This study aimed to identify prognostic factors and provide a novel image classification method for patients with Fournier gangrene.

Materials and methods:
A total of 40 consecutive patients diagnosed with Fournier gangrene between January 2003 and December 2022 were enrolled. Demographic characteristics, clinical presentations, management strategies, and outcomes were retrospectively analyzed.

Results:
The overall survival rate was 87.5% (35/40). Diabetic foot history, chronic kidney disease, end-stage renal disease, or peripheral arterial occlusive disease were significantly (P < 0.05) more common in nonsurvivors than in survivors. Among the parameters of the Fournier’s Gangrene Severity Index, only the initial creatinine level was significantly associated with mortality (P = 0.02). Nevertheless, the Fournier’s Gangrene Severity Index score with a cutoff score of 9 remained a useful indicator of death (P = 0.04). Patients with grade II (extensive) invasion determined by whole abdominal computed tomography had significantly higher mortality rates than those with grade I (nonextensive) (37.5% versus 6.3%, P = 0.04).

Conclusion:
Patients with a history of diabetic foot, chronic kidney disease, end-stage renal disease, and peripheral arterial occlusive disease had a higher risk of death. Early image computed tomography studies are essential for evaluating the risk and extent of the disease. More predictive tools are needed to assess this aggressively infectious disease.
The role of sensory stimuli in delivering memorable dining experiences
Authors: Kim Jong-Hyeong , Kim Seongseop (Sam) , Wang Lin 
Published: December 2024

Purpose
In the context of increasing concerns about health, nutraceutical restaurants that provide health benefits have emerged in the marketplace. However, customer experiences at these restaurants are poorly understood. This study focused on sensory experiences and examined the underlying mechanism by which they contribute to memorable dining experiences. Grounded in cognitive appraisal theory, this study developed a memorable dining experience model that links sensory stimuli, meaningfulness, novelty, emotions, and behavioral intentions.

Design/methodology/approach
Data were collected from 880 Chinese customers who dined at traditional Chinese medicine restaurants and were analyzed via partial least squares structural equation modeling.

Findings
The results revealed that sensory stimuli contributed to memorable dining experiences through meaningfulness, novelty, and emotions. Furthermore, memorable dining experiences increased behavioral intentions to spread positive word-of-mouth and revisit intentions. Additionally, customers’ gender moderated the effects of sensory stimuli on meaningfulness and novelty.

Practical implications
The findings of this study can be used to identify important sensory stimuli and their roles in delivering memorable dining experiences in traditional Chinese medicine restaurants. Therefore, this study’s findings contribute to an improved understanding of how to efficiently manage sensory stimuli to stimulate memorable experiences for restaurant patrons.

Originality/value
This study tests the influence of sensory stimuli on the memorable dining experiences of customers in China.
Community acceptance of wind energy projects development in Viet Nam from the perspective of behavioral reasoning theory
Authors: Nguyen Dat Minh , Duong Trung Kien , Dinh Van Chau , Nguyen Thi Le 
Published: December 2024

PurposeThis study aims to present the factors affecting and comparing the difference in community acceptance between groups of survey from the perspective of behavioral reasoning theory (BRT).Design/methodology/approachThis study presents a quantitative method through conducting survey of 152 local residents from three provinces of Viet Nam.FindingsThis study examines the new approach of “reason for” and “reason against” community acceptance within the context of wind energy development in Viet Nam. This study also suggests that “reason for” have a positive impact on the local community; however, issues like noise and shadow cast by turbine blades are significant challenges that contribute to the “reason against” acceptance. This study’s findings provide evidence of the importance of location and socio – economic impacts in influencing community acceptance and can give some feedback for local policymakers in Viet Nam’s energy sector as they implement wind projects in potential areas.Originality/valueTo the best of the author's knowledge, this study is the first empirical study conducted across three Vietnamese provinces on community acceptance of onshore wind energy. The integration of literature on socio-acceptance with BRT in energy research contributes valuable insights to the fields of energy behavior and energy policy research.
Synergizing ergonomic principles with lean philosophy model towards productivity improvement in the shoes manufacturing industry
Authors: Wodajeneh Shemelis Nesibu , Azene Daniel Kitaw , Sileyew Kassu Jilcha 
Published: December 2024

PurposeThis study aims to address the gap in integrating ergonomic principles with lean principles in the shoe product manufacturing process. The objective is to develop a customized model that effectively combines and synergizes ergonomics and lean principles.Design/methodology/approachPrimary data was collected through on-site observations, interviews and assessment of whole-body discomfort to evaluate the implementation of lean and ergonomic principles in each section of the shoe production process. The collected data were analysed using descriptive statistical tools, content analysis and software such as Microsoft Excel.FindingsThe findings of the study indicate that the case company’s underperformance, achieving only 26.96% of its designed capacity and 50.19% of its planned capacity, is primarily attributed to the poor integration of ergonomic principles with the lean philosophy model. The high prevalence of work-related musculoskeletal disorders (WMSDs) in the shoe production process significantly contributes to a loss of productivity due to increased absenteeism. The factory experiences a labour absenteeism rate of 5.59%, resulting in overtime and additional costs. To address these issues, the study proposes the adoption of 8S principles and an ergo-lean production system model. This model, conceptualized as a building construction structure, effectively eliminates waste in the shoe production process.Practical implicationsThe study’s findings will greatly enhance productivity in the shoe manufacturing sector by establishing a work environment that prioritizes employee needs and well-being. This will have significant practical implications for improving overall productivity in the industry.Originality/valueThis study stands out as it investigates the proactive integration of ergonomics and lean principles in the shoe manufacturing industry, an area that has not been previously explored. By bridging the gap between these two principles, the research contributes to the existing knowledge base.
Effect of Preimplantation Genetic Testing for Aneuploidy on Live Birth Rate in Young Women With Recurrent Implantation Failure: A Secondary Analysis of a Multicentre Randomised Trial
Authors: Guan Hengyu , He Yaqiong , Lu Yao , Huang Jiaan , Wang Yuan , Zhu Qinling , Qi Jia , Lin Wen , Lindheim Steven R. , Wei Zhe , Ding Ying , Sun Yun 
Published: December 2024

ABSTRACTObjectiveTo investigate the benefit of preimplantation genetic testing for aneuploidy (PGT‐A) in recurrent implantation failure (RIF).DesignSecondary analysis of a multicentre, randomised, double‐blind, placebo‐controlled clinical trial.SettingEight academic fertility centres in China, 2018–2020.PopulationOverall, 485 infertile women aged < 38 years were evaluated. They had a history of two or more unsuccessful embryo transfer cycles with at least three good‐quality embryos that had been transferred cumulatively and underwent a single blastocyst transfer with or without PGT‐A. Those with thin endometrium or recurrent pregnancy loss were excluded.MethodsPatients were categorised into PGT‐A and non‐PGT‐A groups. All pregnancies were followed to delivery. Pregnancy and neonatal outcomes were obtained from obstetric and neonatal medical records. Propensity score matching (PSM) and multivariate logistic regression models were applied to adjust for potential confounding factors.Main Outcome MeasuresLBR per embryo transfer.Result(s)There was no significant difference in LBR between the PGT‐A and non‐PGT‐A groups both before (39.1% vs. 41.5%, p = 0.760) and after (39.1% vs. 40.6%, p = 0.862) PSM. Unadjusted and adjusted logistic regression models revealed no beneficial effect of PGT‐A on LBR per embryo transfer (crude odds ratio: 0.91, 95% confidence interval: 0.49–1.69; adjusted odds ratio: 1.04, 95% confidence interval: 0.53–2.03). The incidence of maternal and neonatal complications was not significantly different between the groups.ConclusionsPatients with RIF aged < 38 years do not benefit from PGT‐A. Thus, factors other than genetic abnormalities may contribute to this clinical conundrum.