bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of the PARIHS framework in implementation research and practice—a citation analysis of the literature
Authors: Bergström Anna , Ehrenberg Anna , Eldh Ann Catrine , Graham Ian D. , Gustafsson Kazuko , Harvey Gillian , Hunter Sarah , Kitson Alison , Rycroft-Malone Jo , Wallin Lars 
Published: August 2020

AbstractBackgroundThe Promoting Action on Research Implementation in Health Services (PARIHS) framework was developed two decades ago and conceptualizes successful implementation (SI) as a function (f) of the evidence (E) nature and type, context (C) quality, and the facilitation (F), [SI = f (E,C,F)]. Despite a growing number of citations of theoretical frameworks including PARIHS, details of how theoretical frameworks are used remains largely unknown. This review aimed to enhance the understanding of the breadth and depth of the use of the PARIHS framework.MethodsThis citation analysis commenced from four core articles representing the key stages of the framework’s development. The citation search was performed in Web of Science and Scopus. After exclusion, we undertook an initial assessment aimed to identify articles using PARIHS and not only referencing any of the core articles. To assess this, all articles were read in full. Further data extraction included capturing information about where (country/countries and setting/s) PARIHS had been used, as well as categorizing how the framework was applied. Also, strengths and weaknesses, as well as efforts to validate the framework, were explored in detail.ResultsThe citation search yielded 1613 articles. After applying exclusion criteria, 1475 articles were read in full, and the initial assessment yielded a total of 367 articles reported to have used the PARIHS framework. These articles were included for data extraction. The framework had been used in a variety of settings and in both high-, middle-, and low-income countries. With regard to types of use, 32% used PARIHS in planning and delivering an intervention, 50% in data analysis, 55% in the evaluation of study findings, and/or 37% in any other way. Further analysis showed that its actual application was frequently partial and generally not well elaborated.ConclusionsIn line with previous citation analysis of the use of theoretical frameworks in implementation science, we also found a rather superficial description of the use of PARIHS. Thus, we propose the development and adoption of reporting guidelines on how framework(s) are used in implementation studies, with the expectation that this will enhance the maturity of implementation science.
Sigesbeckia glabrescens Makino extract attenuated the collagen-induced arthritis through inhibiting the synovial hyperplasia and inflammation
Authors: Ma Qiu Shuo , Linghu Ke-Gang , Zhang Tian , Zhao Guan Ding , Xiong Wei , Xiong Shi Hang , Zhao Mingming , Xu Wei , Yu Juan , Yu Hua 
Published: August 2020

Abstract
Background
Sigesbeckia glabrescens Makino (SG) has been traditionally used for rheumatism and joint protection. However, the anti-arthritic effects and underling mechanisms of SG have not been demonstrated. In this study, we investigated the anti-arthritic effects and mechanisms of SG extract (SGE) on collagen-induced arthritic rats and interleukin (IL)-1β-stimulated human synovial SW982 cells.

Methods
Rats were induced to arthritis by collagen for 15 days and then received SGE treatment for 35 days. The body weight and arthritis severity score of the rats were monitored weekly. At the end of the experiment, the radiographic and histological changes of rats’ hind paw were obtained; the serum C-reactive protein was detected by enzyme-linked immunosorbent assay (ELISA); the expression levels of interleukin (IL)- 1β, IL6 and IL-10 in the joint muscles were determined by ELISA and immunohistochemical staining; and the level of regulatory T cells (Tregs) in the spleen was detected using flow cytometry. In addition, 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and scratch wound healing assay were used to evaluate the proliferation of SW982 synovial cells. ELISA, western blot and immunofluorescence staining were used to investigate the anti-inflammatory mechanisms of SGE on IL-1β-induced SW982 cells and joint muscles of CIA rats.

Results
SGE attenuated the collagen-induced hind paw swelling, cartilage damage and bone erosion. SGE inhibited the synovial hyperplasia to the articular cavity in the toe joint and ankle. Moreover, SGE decreased the production of C-reactive protein in serum and the expression of IL-6, IL-1β, cyclooxygenase-2 (COX-2) and phosphorylation of NF-κB p65 in the joint muscles. SGE also recovered the decreased Tregs. Results from the in vitro experiments showed that SGE not only inhibited the proliferation and migration of human synovial cell but also inhibited the IL-1β-induced expression of IL-6 and IL-8. Similarly, SGE inhibited the activation of NF-κB and the expression of COX-2.

Conclusions
SGE attenuated the collagen-induced arthritis through inhibiting the synovial hyperplasia and inflammation.
First cases of contagious ovine digital dermatitis in Germany
Authors: Tegtmeyer Philip Christian , Staton Gareth James , Evans Nicholas James , Rohde Judith , Punsmann Teresa Maria , Ganter Martin 
Published: August 2020

AbstractContagious ovine digital dermatitis (CODD) is a significant disease of the ovine foot characterised by severe lameness and progressive separation of the hoof horn capsule from the underlying tissue. Similar to bovine digital dermatitis (BDD), pathogenic members of the genus Treponema including the Treponema medium phylogroup, Treponema phagedenis phylogroup and Treponema pedis are frequently found together in CODD lesions. To date, CODD was only described in Ireland and the United Kingdom. In northern Germany, cases of an unusually severe lameness presented in a sheep flock that had been affected by footrot for several years. These cases were non-responsive to conventional footrot therapies, with some sheep exhibiting substantial lesions of the claw horn that resulted in horn detachment. Lesion swab samples were collected from both clinically affected and asymptomatic animals. In all clinically affected sheep, CODD-associated Treponema phylogroups were detected by polymerase chain reaction. This is the first report of CODD in Germany and mainland Europe, indicating a wider geographic spread than previously considered. In cases of severe lameness attributed to claw lesions in sheep that fail to respond to footrot treatment, CODD should be considered irrespective of geographic location.
Molecular evidence confirms occurrence of Rhipicephalus microplus Clade A in Kenya and sub-Saharan Africa
Authors: Kanduma Esther G. , Emery David , Githaka Naftaly W. , Nguu Edward K. , Bishop Richard P. , Šlapeta Jan 
Published: August 2020

AbstractBackgroundThe tick vectorRhipicephalus micropluswhich transmitsBabesiaspp. and rickettsial pathogens has not been reported in Kenya since 1998. More recently, the pathogenicBabesia bovishas been detected in cattle blood DNA. The status ofR. microplusin Kenya remains unknown. This study employed morphological and molecular tools to characterizeR. microplusoriginating from Kenya and assess the genetic relationships between Kenyan and other AfricanR. microplusgenotypes.MethodsTicks were collected in south-eastern Kenya (Kwale County) from cattle and characterized to investigate the existence ofR. microplus. Genetic and phylogenetic relationships between the Kenyan and other annotatedR. microplusreference sequences was investigated by analysis of the cytochromecoxidase subunit 1 (cox1) gene. To further characterize Kenyan ticks, we generated low coverage whole genome sequences of twoR. microplus, oneR. decoloratusandR. appendiculatus. AB. bovisspecific TaqMan probe qPCR assay was used to detectB. bovisin gDNA fromR. microplusticks.ResultsOccurrence ofR. micropluswas confirmed in Kwale County, Kenya. The KenyanR. microplus cox1 sequences showed very high pairwise identities (> 99%) and clustered very closely with reference AfricanR. microplussequences. We found a low genetic variation and lack of geographical sub-structuring among the Africancox1 sequences ofR. microplus. Four complete mitochondrial (mt) genomes for twoR. microplus, oneR. decoloratusand oneR. appendiculatuswere assembled from next generation sequence data. The mitochondrial genome sequences of the two KenyanR. microplusticks clustered closely with reference genome sequences from Brazil, USA, Cambodia and India formingR. microplusClade A. NoB. boviswas detected in the KwaleR. microplusDNA.ConclusionsThese findings confirm the presence ofR. microplusin Kenya and suggest thatR. microplusClade A is prevalent in cattle in sub-Saharan Africa. These and other recent findings of widespread occurrence ofR. microplusin Africa provide a strong justification for urgent surveillance to determine and monitor the spread ofR. microplusand vector competence ofBoophilusticks forB. bovisin Africa, with the ultimate goal of strategic control.
Long lasting response with trabectedin monotherapy in relapsed metastatic mesenchymal chondrosarcoma
Authors: Tansir Ghazal , Rastogi Sameer , Barwad Adarsh , Dhamija Ekta 
Published: August 2020

Abstract
Background
Mesenchymal chondrosarcoma is an exceedingly rare malignancy, accounting for around 5% of all patients with chondrosarcoma. It is a translocation-related sarcoma that tends to have both local and distant recurrences. Surgery is the mainstay of treatment in localised cases however treatment of advanced cases remains a challenge. The rarity of the disease precludes dedicated clinical trials and hence guidelines for its management are not well defined. The dearth in literature makes it pertinent that the cases treated with newer therapies must be reported to contribute to existing knowledge.

Case presentation
We hereby report a case of a 39-year old male without any comorbidity presenting with pelvic pain and was diagnosed as mesenchymal chondrosarcoma of the pelvis. He underwent an initial curative resection followed by a disease-free interval of 7 months. Subsequently, he was treated with pulmonary metastatectomy and local debulking surgery at time of initial relapse. He was then exposed to multiple lines of palliative chemotherapy, which limited our treatment options upon subsequent disease progression. Based on recent data, the patient was given trabectedin monotherapy as fourth line chemotherapy. He tolerated the therapy well and attained a progression-free survival of 12 months, which is an impactful figure in relapsed setting in this patient population.

Conclusion
This report aims to present a comprehensive review into available and newer treatment choices for mesenchymal chondrosarcoma, and to highlight trabectedin monotherapy as a possible therapeutic option for mesenchymal chondrosarcoma in the relapsed setting.
Study of economic management forecast and optimized resource allocation based on cloud computing and neural network
Authors: He Pinzhen 
Published: August 2020

AbstractAs various factors which affect the development of global market economy become increasingly uncertain, economy and commodity will become more and more fluctuating in economic operation. With its strong nonlinear mapping capacity, artificial neural network has already been applied in many fields, time series analysis, and trend prediction. Cloud computing can interact fast with service provider at the minimum management cost. This paper proposes an economic forecast and optimized resource allocation model based on cloud computing and BP neural network. Its main goal is to break down a complex prediction task into several sub-tasks, effectively reduce the workload of a single computer and enhance the operating efficiency. Simulation results show that the proposed method does not rely on gradient information and has strong optimization calculation ability. At the same time, it can analyze and predict economic management, so as to provide strong decision support for decision makers.
Jensen–Mercer inequality for GA-convex functions and some related inequalities
Authors: İşcan İmdat 
Published: August 2020

AbstractIn this paper, firstly, we prove a Jensen–Mercer inequality for GA-convex functions. After that, we establish weighted Hermite–Hadamard’s inequalities for GA-convex functions using the new Jensen–Mercer inequality, and we establish some new inequalities connected with Hermite–Hadamard–Mercer type inequalities for differentiable mappings whose derivatives in absolute value are GA-convex.
Alternating iterative algorithms for the split equality problem without prior knowledge of operator norms
Authors: Yu Hai , Wang Fenghui 
Published: August 2020

AbstractIn this paper, we study the alternating CQ algorithm for solving the split equality problem in Hilbert spaces. It is, however, not easy to implement since its selection of the stepsize requires prior information on the norms of bounded linear operators. To avoid this difficulty, we propose several modified algorithms in which the selection of the stepsize is independent of the norms. In particular, we consider the case whenever the convex sets involved are level sets of given convex functions.
Some new Hardy-type inequalities on time scales
Authors: El-Deeb Ahmed A. , Elsennary Hamza A. , Baleanu Dumitru 
Published: August 2020

AbstractIn this paper, we will prove some new dynamic inequalities of Hardy-type on time scales. Some of the integral and difference inequalities that will be derived from our results in the continuous and discrete cases are original. The main results will be proved by using the dynamic Hölder inequality, integration by parts formula on time scales, and Keller’s chain rule on time scales. We will apply the main results to the continuous calculus, discrete calculus, andq-calculus as special cases.
Existence and multiplicity of positive solutions for a new class of singular higher-order fractional differential equations with Riemann–Stieltjes integral boundary value conditions
Authors: Liu Lishan , Min Dandan , Wu Yonghong 
Published: August 2020

AbstractIn this work, the aim is to discuss a new class of singular nonlinear higher-order fractional boundary value problems involving multiple Riemann–Liouville fractional derivatives. The boundary conditions are constituted by Riemann–Stieltjes integral boundary conditions. The existence and multiplicity of positive solutions are derived via employing the Guo–Krasnosel’skii fixed point theorem. In addition, the main results are demonstrated by some examples to show their validity.
Iq-Calculus and Iq-Hermite–Hadamard inequalities for interval-valued functions
Authors: Lou Tianyi , Ye Guoju , Zhao Dafang , Liu Wei 
Published: August 2020

AbstractIn this paper, we introduce the Iq-derivative and Iq-integral for interval-valued functions and give their basic properties. As a promotion of q-Hermite–Hadamard inequalities, we also give the Iq-Hermite-Hadamard inequalities for interval-valued functions. At the same time, we give some examples to illustrate the results.
Spatial navigation ability is associated with the assessment of smoothness of driving during changing lanes in older drivers
Authors: Kunishige Masafumi , Miyaguchi Hideki , Fukuda Hiroshi , Iida Tadayuki , Nami Kawabata , Ishizuki Chinami 
Published: August 2020

Abstract
Background
Age-related changes affect driving ability, including the smoothness of driving. This operation requires the use of both allocentric strategies (based on world-centered representations) and egocentric strategies (based on self-centered representations); however, with age, a greater preference for egocentric strategies is evident when driving. Furthermore, an age-related decline occurs in both driving ability and spatial navigation. We therefore assessed the relationship between spatial navigation and driving smoothness and tested whether a driving simulator can be used to evaluate smooth lane changes in older drivers.

Methods
A total of 34 healthy older drivers (mean age: 68.2 ± 5.4 years old) and 20 younger drivers (mean age = 20.2 ± 5.4 years old) participated in this study. The smoothness of driving was assessed using a driving simulator and spatial navigation was assessed using the Card-Placing Test-A/B. We also assessed visual perception and general intellectual function using standard neuropsychological tests.

Results
Older drivers had significantly worse spatial navigation and exhibited less smooth driving than younger drivers. Furthermore, we found a negative correlation between the smoothness of driving and spatial navigation within both groups. These results suggest that the deterioration in spatial navigation in older people may underlie the observed decrease in driving smoothness, and that spatial navigation and smooth driving deteriorate with age.

Conclusions
Considering these results, we found a significant correlation in the older group between the smoothness of vehicle movement and spatial navigation, in the smoothness of vehicle movement between the young and old groups. The smoothness values, which indices thoroughly derived from the driving simulator are indeed showing some evidence in ego/allocentric cognitions, which may change by age. The driving simulator could aid the development of intervention programs or assessment measures for drivers with a decreased function.
The relationship between family function and personality traits with general self-efficacy (parallel samples studies)
Authors: Zakiei Ali , Vafapoor Hosna , Alikhani Mostafa , Farnia Vahid , Radmehr Farnaz 
Published: August 2020

Abstract
Background
General Self-efficacy is a key variable in clinical, educational, social, developmental, health and personality psychology that can affect the outcomes of people’s lives. The present study aimed to investigate the relationship between family functions and personality traits with general self-efficacy among university students and the general population.

Methods
To conduct this two-part study, the first part was carried out on a sample of 500 students, and in the second part the study was repeated on a larger sample consisting of 1000 participants from the general population data were collected from the General Self-Efficacy Scale (GSE), Family Assessment Device (FAD), and the Revised NEO Personality Inventory (NEO PI-R). The analysis was performed using Pearson’s correlation coefficient, Fisher’s z test and regression analysis.

Results
The results of the present study revealed that all the subscales of family functions and all personality traits are significantly related to general self-efficacy among university students and general population (p < 0.001). But in the general population, there was no significant correlation between openness to experience with general self-efficacy) (p > 0.05). Furthermore, the results of regression analysis showed subscales of family functions and all personality traits together can predict 27 and 35% of the variance in general self-efficacy among university students and the general population, respectively.

Conclusion
Personality traits play a role in predicting general self-efficacy, but the personality trait of conscientiousness plays a greater role than other personality traits and also compared to family functioning, personality traits play a greater role in predicting general self-efficacy.
Regional correlation of biochemical measures of amyloid and tau phosphorylation in the brain
Authors: Horie Kanta , Barthélemy Nicolas R. , Mallipeddi Nipun , Li Yan , Franklin Erin E. , Perrin Richard J. , Bateman Randall J. , Sato Chihiro 
Published: August 2020

AbstractAlzheimer’s disease (AD) neuropathologic change is characterized by amyloid plaques and neurofibrillary tangles (NFTs) that consist of aggregated amyloid beta (Abeta) and hyperphosphorylated tau proteins (p-tau), respectively. Although the global relationship between Abeta and p-tau has been studied for decades, it is still unclear whether a regional correlation exists between Abeta and p-tau in the human brain. Recent studies in cerebrospinal fluid (CSF) have suggested that tau phosphorylation at specific sites such as T217 is modified at an early stage of AD when amyloid plaques become detectable. We applied biochemical and mass spectrometry methods in human brain samples with and without Abeta plaque pathology to measure site-specific phosphorylation occupancies in soluble and insoluble tau. Our quantitative results identified multiple residues specifically hyper-phosphorylated in AD, including at sites T111, T153, S184 (or S185), T205, S208, T217, S262, and S285 in brain soluble tau. In contrast, the most enriched phosphorylated residues in brain insoluble tau were T111, S113, T153, T181, S199, S202, T205, T217, T231, S262, and S396. Tau phosphorylation occupancies in the insoluble fraction were relatively constant across brain regions, suggesting that tau has a consistent phosphorylation pattern once it has aggregated into NFTs. We did not find regional association between Abeta42 and insoluble tau. However, the phosphorylation profile of soluble tau in AD brain was highly correlated to that in AD CSF, which was analyzed in a previous study. We also found a higher regional association between total Abeta42 and soluble tau phosphorylation occupancy at residues T111, T153 and T217 in the brain. This study provides insights into regional interactions between amyloidosis and specific tau phosphorylated residues in the human brain and may explain the specific increases of tau species phosphorylation observed in AD CSF.
Natural anti-inflammatory terpenoids in Camellia japonica leaf and probable biosynthesis pathways of the metabolome
Authors: Majumder Soumya , Ghosh Arindam , Bhattacharya Malay 
Published: August 2020

Abstract
Background
Metabolomics of Camellia japonica leaf has been studied to identify the terpenoids present in it and their interrelations regarding biosynthesis as most of their pathways are closely situated. Camellia japonica is famous for its anti-inflammatory activity in the field of medicines and ethno-botany. In this research, we intended to study the metabolomics of Camellia japonica leaf by using gas chromatography-mass spectroscopy technique.

Results
A total of twenty-nine anti-inflammatory compounds, occupying 83.96% of total area, came out in the result. Most of the metabolites are terpenoids leading with triterpenoids like squalene, lupeol, and vitamin E. In this study, the candidate molecules responsible for anti-inflammatory activity were spotted out in the leaf extract and biosynthetic relation or interactions between those components were also established.

Conclusion
Finding novel anticancer and anti-inflammatory medicinal compounds like lupeol in a large amount in Camellia japonica leaf is the most remarkable outcome of this gas chromatography-mass spectroscopy analysis. Developing probable pathway for biosynthesis of methyl commate B is also noteworthy.
Energy of inverse graphs of dihedral and symmetric groups
Authors: Ejima O. , AREMU K. O. , Audu A. 
Published: August 2020

AbstractLet (G,∗) be a finite group and S={x∈G|x≠x−1} be a subset of G containing its non-self invertible elements. The inverse graph of G denoted by Γ(G) is a graph whose set of vertices coincides with G such that two distinct vertices x and y are adjacent if either x∗y∈S or y∗x∈S. In this paper, we study the energy of the dihedral and symmetric groups, we show that if G is a finite non-abelian group with exactly two non-self invertible elements, then the associated inverse graph Γ(G) is never a complete bipartite graph. Furthermore, we establish the isomorphism between the inverse graphs of a subgroup Dp of the dihedral group Dn of order 2p and subgroup Sk of the symmetric groups Sn of order k! such that $2p = n!~(p,n,k \geq 3~\text {and}~p,n,k \in \mathbb {Z}^{+}).$
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