bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydroxychloroquine in the treatment and prophylaxis of SARS-CoV-2 infection in non- human primates
Authors: Maisonnasse Pauline , Guedj Jérémie , Contreras Vanessa , Behillil Sylvie , Solas Caroline , Marlin Romain , Naninck Thibaut , Pizzorno Andres , Lemaitre Julien , Gonçalves Antonio , Kahlaoui Nidhal , Terrier Olivier , Fan Raphael Ho Tsong , Enouf Vincent , Bosquet Nathalie Dereuddre- , Brisebarre Angela , Toure Franck , Chapon Catherine , Hoen Bruno , Lina Bruno , Calatrava Manuel Rosa , Werf Sylvie van der , Lamballerie Xavier de , Grand Roger Le 
Published: May 2020

Abstract
COVID-19 has become a pandemic that has caused over 200,000 deaths worldwide, with no antiviral drug or vaccine yet available. Several clinical studies are ongoing to evaluate the efficacy of repurposed drugs that have demonstrated antiviral efficacy in vitro. Among these candidates, hydroxychloroquine (HCQ) has been given to thousands of individuals worldwide but definitive evidence for HCQ efficacy in treatment of COVID-19 is still missing.We evaluated the antiviral activity of HCQ both in vitro and in SARS-CoV-2-infected macaques. HCQ showed antiviral activity in monkey African green monkey kidney (VeroE6) cells but not in a model of reconstituted human airway epithelium. In macaques, we tested different treatment strategies in comparison to placebo, before and after peak viral load, alone or in combination with azithromycin (AZTH). Neither HCQ nor HCQ+AZTH showed a significant effect on the viral load levels in any of the tested compartments. When the drug was used as a pre-exposure prophylaxis (PrEP), HCQ did not confer protection against acquisition of infection.Our findings do not support the use of HCQ, either alone or in combination with AZTH, as an antiviral treatment for COVID-19 in humans.
Analisis Implementasi E-Bugdeting dengan Menggunakan Model CIPP pada Pemerintah Provinsi DKI Jakarta
Authors: Rahman Rama Andika Thio 
Published: May 2020

This study aimed to analyse the effectiveness of e-Budgeting implementation in the Provincial Government of DKI Jakarta by using CIPP (Context, Input, Process, and Product) model from Stufflebeam (2003). The type of this research was a qualitative research using case-study approach. The data were collected using interviews and documentation studies. The results of this study revealed that the implementation of e-Budgeting in DKI Jakarta Provincial Government was feasible to proceed as it was proven to be effective when viewed from the four components of CIPP Model that is context which focuses on the success of achieving the initial goal of budget transparency and accountability. Furthermore, in terms of inputs, the use of facilities, infrastructure and human resources was adequate. Viewed from the process, e-Budgeting simplified and minimized errors in the process of preparing the work plan and budget (RKA). From the output (Product), it improved the quality of regional budget (APBD) in terms of conformity with the Regional Medium-Term Development Plan (RPJMD) document and the control management of budget that plays an active role.
INFORMATION SHARING AND MECHANISM IN ONLINE COMMUNITY
Authors: Andriane Septiane , Pinem Ave Adriana , Handayani Putu Wuri 
Published: May 2020

The emergece of C2C (customer to customer) community in e-commerce platform is expected to boost the number of SME moving to online plaform. Since the community could provide information and experience required by new e-commerce players. This study aims to analyse what information is shared by members in C2C community and what is the information sharing mechanism that implemented on it. Netnographic study was conducted by observing 1002 posts from the Bukalapak community for six months. As Bukalapak is one of the largest C2C platfom in Indonesia. The result shows that the information shared could be classified by keyword in to five classes, namely categories of tips and tricks, ideas and problems with third parties, ideas and problems of features, community, and question and answer. The information category that has not been covered by Bukalapak original categories is and problems with third parties which mentioned in many posts by community member. The mechanisms used to share the information are including, standard, policy, status and reward.
Детерминанты жизнестойкости у трех поколений современной России
Authors: Федотова Вера А. 
Published: May 2020

Introduction. Generational differences have been scarcely investigated. The factors that help individuals to cope with stressful factors and increasing tension are worth consideration in the context of present-day reality. This study addresses the predictors of hardiness in different generations of Russians. Methods. A sample of respondents from various regions of the Russian Federation, aged from 18 to 75 years, took part in the empirical study of values, subjective economic well-being, and hardiness factors. The study used the following techniques: (a) the PVQ-R technique for measuring individual values, (b) the Test of Hardiness by D. A. Leont'ev, (c) the Subjective Economic Well-being technique by V. A. Khashchenko, and (d) the Meaning-in-Life Orientations test (MOL) by D. A. Leont'ev), the modified version of the Purpose-in-Life test (PIL). Results. Representatives of generation Y have a higher overall level of hardiness. The external locus of control influences hardiness in all the three examined generations. This influence is positive for generations X and Y, and negative for baby boomers. Economic anxiety has a negative impact on hardiness in representatives of generations X, Y, and baby boomers. The values of individualism – ‘independence: thinking’ and ‘achievement’ – influence hardiness in representatives of generations X and Y. Discussion. Increased dissatisfaction with financial situation, the inability to save money, and increased economic anxiety decrease the level of hardiness in Russians. The increase in financial well-being can contribute to an increase in hardiness across all the groups of respondents. Independence in the choice of actions, ambitious goals in life, the desire to be successful, and the need for feeling safe and secure increase the ability to withstand stress among representatives of generations X and Y.
Eco-friendly and Enantiospecific Biginelli Synthesis Using (+)-Myrtenal as the Substrate – An Impeccable and Unequivocal Analysis of the Product
Authors: Dias Benincá Luiza Albino , Pereira Ligiéro Carolina Bastos , da Silva Santos Jonas , Junior Joel Jones , da Silva Flavia Martins 
Published: May 2020

Background:
We found in the literature, an excellent review of the Biginelli reaction that addresses
the methodologies for obtaining enantiopure dihydropyrimidinones (DHPMs). In 1992, optically pure DHPMs
were obtained by fractional crystallization of the diastereomeric ammonium salt derivative with (S)-(-) and (R)-
(+)-α-methyl benzylamine and by other chiral resolution techniques, such as chiral high-performance liquid
chromatography (HPLC). Asymmetric syntheses of these compounds are also explained in the literature. The
main strategy is to use acid catalysts such as organophosphates, organometallic complexes, amines and
diamines, nanocomposites, and chiral ionic liquids, e.g., L-prolinium sulfate (Pro2SO4).

Objective:
The objective was to study the Biginelli reaction with a chiral aldehyde.

Methods:
A mixture of ethyl acetoacetate (0.26 g, 3 mmol), urea (0.18 g, 3 mmol) and ethyl lactate (EL) (1
mL) was left under heating at 70°C and stirring for 1 h. Next, (-)-(1R)-myrtenal (0.45 g, 3 mmol) was added,
and the medium was heated for 5 h more until the formation of a white solid. Ten millilitres of distilled water
was added, and the product was extracted with CH2Cl2 (3 x 4 mL). The solvent was evaporated, and the
product was recrystallized from ethanol-water.

Results and Discussion:
(+)-Myrtenal was used as a chiral substrate for a study that led to ethyl (R)-4-((1R,5S)-
6,6-dimethylbicyclo [3.1.1]hept-2-en-2-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate by the
Biginelli synthesis using EL as a green solvent. The result is the first example of the enantiospecific Biginelli
reaction. The product was exhaustively characterized by several physical analysis methods, i.e., 1H, 13C and 2D
nuclear magnetic resonance (NMR) spectroscopies, infrared (IR) spectroscopy, mass spectrometry (MS), and
high-resolution MS (HRMS), and its structure was unequivocally elucidated by X-ray crystallography.

Conclusion:
Compound (4R)-4-(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)-6-methyl-2-oxo-1,2,3,4- tetrahydropyrimidine-
5-ethyl carboxylate is the first example of the enantiospecific Biginelli reaction. In addition,
the process has the advantage of using EL as a green solvent. The product was characterized by 1H, 13C, and 2D
NMR and IR spectroscopy, MS, HRMS, and X-ray crystallography.
DFT Studies of Distinct Anilines with p-Hydroxycinnamic Acids for Antioxidant Profile
Authors: Kumar Ch. Ravi S. , Jha Anjali , Deepthi Sri 
Published: May 2020

Background:
Life style and jobs in current situations have generated increased free
radicals such as hydroxyl (OH•) and superoxide (O2•) radicals, thereby increasing stress in humans.
Interest in search of antioxidants that trap these free radicals has increased to relieve stress.
β-carotene (provitamin A), ascorbic acid (vitamin C), tocopherol or vitamin E, Trolox; butyl hydroxy
toluene and phenolic compounds are the well-known antioxidants. Several methods evaluate
the antioxidant property existing in natural substances (medicinal plants and agri-food products)
and synthetic compounds (2-methyl-3- (pyrrolidin-2-ylideneamino) quinazolin-4 (3H) –one and
3,3'- (1,4- phenylenebis (methanylylidene)) bis (azanylylidene) (2-methyl-quinazolin-4 (3H) -one).

Objective:
The objective of this study is to focus on complexes with p-hydroxycinnamic acids to
trap free radicals in a greener way.

Method:
Spectroscopic shifts and structural studies were employed to attribute electronic properties
responsible for antioxidant profile. Spectroscopic shifts in wavenumbers were attributed with
Fourier Transform Infrared Spectra (FTIR) and Fourier Transform Raman spectra (FT Raman
Spectra). Structural studies were performed with Gaussian package, electron density method the
B3LYP method, basis set 6-31(d) for attributing electronic properties responsible for antioxidant
profile.

Result:
Interpretation of FTIR spectra revealed spectroscopic shifts in wavenumbers in all the
complexes responsible for bonding. Further, studies confirmed the formation of complex with reduced
intensities in Raman spectra. Computational studies revealed enhancement in molecular and
electronic properties responsible for antioxidant power.

Conclusion:
Studies revealed that complex with p-nitroaniline contribute to greater acceptor and
donor power responsible for antioxidant power. These higher powers suggest the best antiradicals
to trap free radicals.
The Disclosure of Sharia Non-Compliance Income: Comparative Study between Full-fledged and Subsidiaries Malaysian Islamic Banks
Authors: Puneri Atharyanshah , Chora Moustapha , Ilhamiddin Nazarov , Benraheem Hafiz 
Published: May 2020

<p><em>The purpose of this paper is to </em><em>analyze to what extend Islamic banks in Malaysia practice disclosure regarding Sharia non-compliant income. Furthermore, this paper also investigates how bank distribute the Sharia non-compliant income. </em><em>This paper acquires qualitative approach. The qualitative approach is adopted by doing</em><em>a document analysis</em><em>about the literatures from previous studies that </em><em>the Sharia non-compliant income.</em><em>Based on the data collected, </em><em>Bank Islam clearly and properly discloses its Sharia non-compliance income and we recommend any other Islamic banks to follow it. Also, the study find out that does not matter whether they are full-fledge or subsidiaries, the practice is quite the same.</em><em></em></p>
Meningkatkan Hasil Belajar Matematika Materi Penjumlahan Pecahan Penyebut Berbeda Melalui Model Pembelajaran Kooperatif Tipe STAD (Student Teams Achievement Divisions ) Pada Kelas Vb MIN 3 Bantul
Authors: Atmi Suwi 
Published: May 2020

<p>Learning using the STAD model is motivated by the low activity and student learning outcomes in mathematics with the subject of the addition of the fraction of the denominator of Bebeda in class VB MIN 3 Bantul. This is the cause because teachers do not use methods that activate students so students can participate in the learning process. Therefore learning is carried out using the STAD model. The class action using the STAD type cooperative learning model is carried out in 2 cycles.</p><p> Learning using the STAD model aims to obtain data to determine the effectiveness of the type of STAD cooperative learning model in improving learning achievement and student learning activeness in learning mathematics. Learning using the STAD model is carried out in 2 cycles. Each cycle consists of 2 meetings. The subject of learning using the STAD model is students in class VB MIN 3 Bantul consisting of 10 male students and 7 female students. Learning using the STAD model was carried out in the first semester of the 2018/2019 school year between August and September 2018. The data collection technique used observation sheets and test sheets during action and implementation.</p><p> The learning outcomes using the STAD model in the first cycle show that the activity and learning achievement increase is still small in scale. Out of 17 students, 11 students completed their studies and 6 students did not complete their studies. In the second cycle learning achievement increased significantly, from 17 students 17 students completed study. Based on the findings, data analysis and data processing obtained from the evaluation evaluation of each cycle in learning using this STAD model, it can be used as a reference regarding the use of STAD type cooperative learning models in the learning process can improve student learning outcomes in learning Addition of Denominators to Verbal Classes in class VB MIN 3 Bantul.</p><p> </p><p>Keywords: activeness, learning achievement, STAD type cooperative learning</p>
Pengaruh Living Values Education Program (LVEP) terhadap Penanaman Anti-radikalisme Siswa SD dalam Pembelajaran Tematik
Authors: Apriani An-Nisa 
Published: May 2020

<p class="abstrak">Penelitian ini bertujuan untuk mengetahui pengaruh <em>LVEP</em> terhadap penanaman paham anti-radikalisme siswa SD kelas II dalam pembelajaran tematik. Jenis penelitian ini adalah <em>quasi experiment</em> dengan desain <em>pretest-posttest control group design</em>. Populasi dalam penelitian ini adalah seluruh siswa Kelas II SD yang terdiri dari lima kelas. Sampel terdiri dari dua kelas diambil dari kelima kelas tersebut untuk diberi perlakuan dengan menggunakan metode <em>LVEP</em> dan konvesional. Pemilihan sampel dilakukan secara acak dengan memperhatikan karakteristik siswa yang heterogen berdasarkan hasil wawancara dan observasi peneliti dalam pembelajaran tematik. Kelompok kontrol diberi perlakuan dengan pembelajaran konvensional, sedangkan kelompok eksperimen diberi perlakuan dengan menggunakan <em>LVEP</em>. Teknik pengumpulan data yang digunakan adalah observasi dan wawancara. Sedangkan teknik analisis data yang digunakan adalah uji-t dengan taraf signifikansi 0,05.</p><p class="abstrak">Hasil penelitian menunjukkan bahwa ada perbedaaan yang signifikan antara penanaman paham anti-radikalisme dengan <em>LVEP</em> dan pembelajaran konvensional. Perbedaaan tersebut terlihat di semua subkarakter anti-radikalisme yang mencakup nilai <em>citizenship</em> dengan hasil uji-t 0,065, nilai <em>compassion</em> dengan hasil uji-t 0,434, nilai <em>courtesy</em> dengan hasil uji-t 0,700, nilai <em>fairness</em> dengan hasil uji-t 0,504, nilai <em>moderation</em> dengan hasil uji t 1,000, nilai <em>respect for other</em> dengan hasil uji-t 0,826, nilai <em>respect for creator</em> dengan hasil uji-t 0,507, nilai <em>self control</em> dengan hasil uji-t 0,303, dan nilai <em>tolerance</em> dengan hasil uji t 0,676.</p><p class="abstrak"><strong>Kata Kunci: </strong><em>LVEP</em>, anti-radikalisme, pembelajaran tematik</p>
Implementasi ASCO (Analyzing, Solving Problems, ans Comparing) terhadap Pembelajaran Membaca Kritis
Authors: Hariyati Nuria Reny 
Published: May 2020

<p class="StyleAuthorBold">Abstract</p><p class="abstrak"><em>Research on overcoming exposure to radical issues with critical thinking on critical reading learning is still rarely done. This research is important to be carried out in the reading of the story to avoid radical issues that have been entered in university by using the Asco method (Analyzing, Solving Problems, Comparing). This research approach uses the Quasi-Times Design Series with Control Group experiment. The research data collection, namely the initial test scores and final tests. The experimental group was B2-18 and the control group was B3-18. Data analysis of this study used the One Way Anova SPSS test for Windows with a significance level of &lt;0.05. The results of this study, namely (1) A homogeneous group test of 0.049 which was declared valid because&gt; 0.05 to test this relationship; (2) Anova test of the two groups of 0,000 was declared significant because &lt;0.05. The results showed that there was a significant influence of Asco (Analyzing, Solving Problems, Comparing) on critical reading learning. </em></p><p class="abstrak" align="left"><em> </em></p><strong><em>Keywords:</em></strong><em> Asco (Analyzing, Solving Problems, Comparing), Implementation, Critical ReadingLearning </em>
Analisis Peran Kepala Sekolah dalam Menerapkan Kedisiplinan Guru di MI Ma’arif Garongan Kulonprogo
Authors: , Sukati 
Published: May 2020

<p>Penelitian ini dilatar belakangi oleh kedisiplinan guru datang kantor tidak sesuai jam kantor, masih maraknya kelas kosong disaat jam pelajaran, kedisiplinan menjadi titik permasalahannya. Kedisiplinan seorang guru sangat mempengaruhi kedisiplinan siswa, jika kedisiplinan guru baik akan berdampak positif pada siswa begitupun sebaliknya. Disamping itu ada sosok figur yang menjadi panutan atau pemimpin yang berperan penting dalam dunia sekolah yaitu kepala sekolah. Oleh sebab itu penelitian ini bertujuan untuk mengetahui bagaimana peran kepala sekolah dalam menerapkan kedisiplinan guru di sekolah MI Ma’arif Garongan, Kulonprogo Yogyakarta. Dan untuk mengetahui faktor penghambat dan pendukung dalam menerapkan kedisiplinan guru di MI Ma’arif Garongan Kulonprogo Yogyakarta.</p><p>Jenis penelitian ini merupakan jenis penelitian kualitatif dengan teknik pengumpulan data menggunakan teknik observasi, wawancara dan dokumentasi.</p><p> Anaisis Hasil penelitian menunjukkan bahwa: 1) Peran Kepala sekolah dalam menerapkan kedisiplinan guru di MI Ma’arif Garongan Kulonprogo Yogyakarta. adalah: Kepala sekolah berperan sebagai pelaksana, perencana, seorang ahli, pelindung, Pemegang tanggung jawab, sebagai pencipta, dan sebagai wasit. 2) faktor penghambat serta solusi kepala sekolah dalam menerapkan kedisiplinan guru di MI Ma’arif Garongan Kulonprogo Yogyakarta adalah faktor keadaan keluarga, keadaan sekolah, keadaan masyarakat. sedangkan solusi kepala sekolah dalam menerapkan kedisiplinan guru di MI Ma’arif Garongan adalah melakukan musyawarah bersama untuk mencari jalan keluar.</p>
SYNERGISM BETWEEN PROBIOTICS AND HERBS TO MANAGE TYPE 2 DIABETES IN RATS
Authors: ALI HODA A. , MOHAMED SAHAR H. , ALHARBI HEND F. , ALGHESHAIRY REHAM M. 
Published: May 2020

Objective: This study aims to explore the adjuvant effect of multi-strain probiotics with either saffron, cardamom, ginger, or cinnamon herbs to achieve synergistic management for controlling type 2 diabetes (T2D).
Methods: Eighty-eight adult male, Wistar rats were used. Eight rats were kept as healthy control. Eighty rats were used to induce type 2 diabetic rats (T2DR) and were randomly assigned to ten groups. One group was an offer to 0.2 ml multi-strain probiotics orally. The rest of T2DR were gavage with 100 mg/kg aqueous extract of saffron, cardamom, ginger, or cinnamon without or with 0.2 ml multi-strain probiotics orally. Bodyweight gain (BWG), and feed efficiency ratio (FER) were recorded. Determination of oral glucose tolerance test (OGTT), serum insulin, C-peptide, HDL, LDL, HDL/total cholesterol ratio were performed. Serum antioxidant activity, Th1and Th2 cytokines and histopathology of the pancreas were done.
Results: Comparable with T2DR, solely multi-strain probiotics or with herbs caused a significant reduction in BWG (P<0.05). Groups fed saffron, cardamom, and ginger and enriched with multi-strain probiotic showed significant improvement in OGTT, serum insulin, C-peptide and lipid abnormalities (P<0.05) compared to T2DR. Besides, they had antioxidant and anti-inflammatory effects. The group received ginger alone exerted anti-hyperglycemia and anti-inflammatory effects. However, cinnamon had a moderate anti-diabetic effect and solely probiotics did not show a significant benefit for all parameters except BWG.
Conclusion: Cardamom, saffron, and ginger enriched with multi-strain probiotics achieve a synergistic relationship for managing T2D. This finding exhibits a possible new hypothesis to manage diabetes that needs further study.
PERPUTARAN MODAL KERJA, LIKUIDITAS DAN PROFITABILITAS PERUSAHAAN
Authors: Juanda Ahmad , Setyabudi Ginanjar Arief 
Published: May 2020

The purpose of this research is to examine the influence of working capital turn over and liquidity to profitability. The population in this research is all of the fast-moving consumer goods listed company in the Indonesian Capital Market Directory and publishes financial reports in 2016-2018. A sample is determined by a purposive sampling technique based on specified criteria and obtained as many as 24 companies. The research data is secondary data with the collection method uses documentation technique. Data analysis uses Multiple Linear Regression. The results show that working capital turn over (WCTO) and liquidity (CR) simultaneously have a significant effect on profitability (ROA) amount 34,6% while there remaining 65,4% is influenced by other factors. Partially, the working capital turn over (WCTO) variable has a significant effect on profitability (ROA) and liquidity (CR) variable has a significant effect on profitability (ROA).