bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical Outcomes of Bony Batten Grafting Through Endonasal Septoplasty in the Correction of Caudal Septum Deviation
Authors: Aksakal Ceyhun 
Published: December 2019

Objective:
The aim of the present study was to evaluate the efficiency and usefulness of bony batten grafts through endonasal septoplasty in the correction of caudal septum deviations.

Method:
In this case-controlled retrospective study, 65 patients who had bony batten graft procedure for the correction of caudal septum deviation using endonasal septoplasty with complete pre-operative and post-operative questionnaire information and complete post-operative follow-up data (an average follow-up period of 24.1 months) in our hospital in September 2013 and August 2018 period were evaluated. Nasal Obstruction Symptoms Evaluation (NOSE) scores of the patients before and after the operation were compared. Besides, severity of nasal symptoms (mouth dryness, hyposmia, rhinorrhea, epistaxis and snoring) before and after the operation was compared using visual analog scale (VAS). Complications which developed in post-operative period were also analyzed.

Findings:
Average age of the 65 patients (14 female and 51 male) was 27.6 ± 11.3. A straight septum was achieved in 57 patients (87.6%) in post-operative period while 8 patients (12.4%) had residual deviation. Average pre-operative NOSE score was 79.8 ± 22.3 while average post-operative NOSE score was 21.4 ± 4.6 and the difference was significant (P < 0.0001). Significant improvements were observed in VAS scores of all evaluated symptoms in post-operative period. Two patients developed septal hematoma in post-operative period.

Conclusion:
Bony batten graft procedure through endonasal septoplasty is an efficient and useful method with low complication rate for the correction of deviation of caudal septum.
The vagus nerve is necessary for the rapid and widespread neuronal activation in the brain following oral administration of psychoactive bacteria
Authors: Bharwani Aadil , West Christine , Champagne-Jorgensen Kevin , Neufeld Karen-Anne McVey , Ruberto Joseph , Kunze Wolfgang A. , Bienenstock John , Forsythe Paul 
Published: December 2019

AbstractThere is accumulating evidence that certain gut microbes modulate brain chemistry and have antidepressant-like behavioural effects. However, it is unclear which brain regions respond to bacteria-derived signals or how signals are transmitted to distinct regions. We investigated the role of the vagus in mediating neuronal activation following oral treatment withLactobacillus rhamnosus(JB-1).Male Balb/c mice were orally administered a single dose of saline or a live or heat-killed preparation of a physiologically active bacterial strain,Lactobacillus rhamnosus(JB-1). 165 minutes later, c-Fos immunoreactivity in the brain was mapped, and mesenteric vagal afferent fibre firing was recorded. Mice also underwent sub-diaphragmatic vagotomy to investigate whether severing the vagus prevented JB-1-induced c-Fos expression. Finally, we examined the ΔFosB response following acute versus chronic bacterial treatment.While a single exposure to live and heat-killed bacteria altered vagal activity, only live treatment induced rapid neural activation in widespread but distinct brain regions, as assessed by c-Fos expression. Sub-diaphragmatic vagotomy abolished c-Fos immunoreactivity in most, but not all, previously responsive regions. Chronic, but not acute treatment induced a distinct pattern of ΔFosB expression, including in previously unresponsive brain regions.These data identify that specific brain regions respond rapidly to gut microbes via vagal-dependent and independent pathways, but suggest long-term exposure is required for the chronic brain activity associated with behavioural changes.
Characterization of the Key Region and Phosphorylation Sites of EcaICE1 for its Molecular Interaction with EcaHOS1 Protein from Eucalyptus camaldulensis
Authors: Cheng Ling , Zhang Weihua , Hu Jianlin , Zhang Ziyang , Liu Yan , Lin Yuanzhen 
Published: December 2019

AbstractICE1 (inducer of CBF expression 1), a MYC-like bHLH transcriptional activator, plays an important role in plant under cold stress via regulating transcriptional expression of downstream cold-responsive genes. Ubiquitination-proteasome pathway mediated by high expression of osmotically responsive gene1 (HOS1) can effectively induce the degradation of ICE1 and decrease the expression of expression of CBFs and their downstream genes under cold stress response in Arabidopsis, but the knowledge about ubiquitination regulation of ICE1 by HOS1 is still limited in woody plants. In this study, a complete open reading frame of EcaICE1 gene and EcaHOS1 was amplified from the tissue culture seedlings of Eucalyptus camaldulensis. Yeast two-hybrid (Y2H) and BiFC assay results showed that EcaICE1 can interact with EcaHOS1 protein in the nucleus, and further Y2H assay demonstrated that the 126-185 amino acid region at the N-terminus of EcaICE1 protein was indispensable for its interaction with EcaHOS1 protein. Moreover, we found that the amino acids at positions 143, 145, 158 and 184 within the key interaction region were the potential phosphorylation sites of EcaICE1 based on bioinformatics analysis, and that only the substitution of Serine (Ser) 158 by Alanine (Ala) blocked the protein-protein interactions between EcaICE1 and EcaHOS1 by Y2H and β-galactosidase assays using site-direct mutagenesis. In summary, we first reported that EcaICE1 could interact with EcaHOS1 protein in Eucalyptus, and identified Ser 158 of EcaICE1 as the key phosphorylation site for its interaction with EcaHOS1 protein.
Complementation between pathological prion protein subassemblies to cross existing species barriers
Authors: Igel-Egalon Angélique , Laferrière Florent , Tixador Philippe , Moudjou Mohammed , Herzog Laetitia , Reine Fabienne , Torres Juan Maria , Laude Hubert , Rezaei Human , Béringue Vincent 
Published: December 2019

AbstractBackgroundprion replication results from the autocatalytic templated assisted conversion of the host-encoded prion protein PrPCinto misfolded, polydisperse PrPSc conformers. Structurally distinct PrPScconformers can give rise to multiple prion strains. Within and between prion strains, the biological activity (replicative efficacy and specific infectivity) of PrPScassemblies is size-dependent and thus reflects an intrinsic structural heterogeneity. The contribution of such PrPScheterogeneity across species prion adaptation, - which is believed to be based on fit-adjustment between PrPSctemplate(s) and host PrPC-, has not been explored.Methodsto define the structural-to-fitness PrPSclandscape, we measured the relative capacity of size-fractionated PrPScassemblies from different prion strains to cross mounting species barriers in transgenic mice expressing foreign PrPc.Resultsin the absence of a transmission barrier, the relative efficacy of the isolated PrPScassemblies to induce the disease is superimposable to the efficacy observed in the homotypic context. However, in the presence of a transmission barrier, size fractionation overtly delays and even abrogates prion pathogenesis in both neural and extraneural, prion-permissive tissues, for reason independent of the infectivity load of the isolated assemblies. This suggests that a synergy between structurally distinct PrPScassemblies in the inoculum is requested for crossing the species barrier. We further strengthen this hypothesis by showing that altering, by serial dilution, PrPScassemblies content of unfractionated inocula reduce their specific infectivity in an aberrant manner, solely in the presence of a transmission barrier.Conclusionsour data support a mechanism whereby overcoming prion species barrier requires complementation between structurally distinct PrPScassemblies. This work provides key insight into the “quasi-species” concept applied to prions, which would not necessarily rely on prion sub-strains as constituent but on structural PrPScheterogeneity within prion population.
Nearest-neighbor Projected-Distance Regression (NPDR) for detecting network interactions with adjustments for multiple tests and confounding
Authors: Le Trang T. , Dawkins Bryan A. , McKinney Brett A. 
Published: December 2019

AbstractMachine learning feature selection methods are needed to detect complex interaction-network effects in complicated modeling scenarios in high-dimensional data, such as GWAS, gene expression, eQTL, and structural/functional neuroimage studies for case-control or continuous outcomes. In addition, many machine learning methods have limited ability to address the issues of controlling false discoveries and adjusting for covariates. To address these challenges, we develop a new feature selection technique called Nearest-neighbor Projected-Distance Regression (NPDR) that calculates the importance of each predictor using generalized linear model (GLM) regression of distances between nearest-neighbor pairs projected onto the predictor dimension. NPDR captures the underlying interaction structure of data using nearest-neighbors in high dimensions, handles both dichotomous and continuous outcomes and predictor data types, statistically corrects for covariates, and permits statistical inference and penalized regression. We use realistic simulations with interactions and other effects to show that NPDR has better precision-recall than standard Relief-based feature selection and random forest importance, with the additional benefit of covariate adjustment and multiple testing correction. Using RNA-Seq data from a study of major depressive disorder (MDD), we show that NPDR with covariate adjustment removes spurious associations due to confounding. We apply NPDR to eQTL data to identify potentially interacting variants that regulate transcripts associated with MDD and demonstrate NPDR’s utility for GWAS and continuous outcomes.
A Novel LysR-Type Global Regulator RpvA Controls Persister Formation and Virulence inStaphylococcus aureus
Authors: Han Jian , Liu Zhe , Xu Tao , Shi Wanliang , Xu Xiaogang , Wang Sen , Ji Lei , Xu Yuanyuan , Peng Qi , Li Weiping , Zhang Ying 
Published: December 2019

AbstractStaphylococcus aureusis the leading cause of wound and nosocomial infections. Persister formation and virulence factors play crucial roles duringS. aureusinfection. However, the mechanisms of persister formation and its relationship to virulence inS. aureusare poorly understood. In this study, we screened a transposon mutant library and identified a LysR-type global transcriptional regulator NWMN_0037, which we called RpvA, for regulator of persistence and virulence, whose mutation leads to higher susceptibility to antibiotics ampicillin and norfloxacin and various stresses including oxidative stress, heat, and starvation in late exponential and early stationary phase. Interestingly, therpvAmutant was highly attenuated for virulence compared with the parentS. aureusNewman strain as shown by a much higher lethal dose, reduced ability to survive in macrophages and to form abscess in the mouse model. Transcriptional profiling and metabolomic analysis revealed that RpvA could repress multiple genes includinggapR,gapA,tpi,pgm,eno,glpD, andacsexpression and enhance production of numerous intermediate metabolites including dihydroxyacetone phosphate, 2-phosphoglycerate, acetyl-CoA, glycerol 3-phosphate, L-glutamate in the cells. The differentially expressed genes and altered production of metabolites are distributed in global metabolism including carbohydrate metabolism, amino acid metabolism, energy metabolism and metabolism of cofactors and vitamins. These metabolic adjustments could cause the cell to go into dormancy, thus promotingS. aureusto convert to persisters. In addition, RpvA could upregulate the expression of virulence genes includinghla,hlgA,hlgB,hlgC,lukF,lukS,lukD,seaandcoa, and carotenoid biosynthesis genes (crtI,crtM,crtN). Gel shift assay confirmed that RpvA could bind to the promoters of candidate target geneshla,hlgBandcrtM, thus promotingS. aureusvirulence. Because of the important functions of the RpvA, it may serve as an attractive target for developing new drugs and vaccines to more effectively controlS. aureusinfections.
ACPT gene is inactivated in mammalian lineages that lack enamel and teeth
Authors: Mu Yuan , Huang Xin , Liu Rui , Gai Yulin , Liang Na , Yin Daiqing , Shan Lei , Xu Shixia , Yang Guang 
Published: December 2019

AbstractLoss of tooth or enamel is widespread in multiple mammal lineages. Although several studies have been reported, the evolutionary mechanisms of tooth / enamel loss are still unclear. Most previous studies have found that some tooth-related genes have been inactivated in toothless and / or enamel-less mammals, such as ENAM, ODAM, C4orf26, AMBN, AMTN, DSPP, etc. Here, we conducted evolutionary analyses on ACPT plays a key role in amelogenesis, to interrogate the mechanisms. We obtained the ACPT sequences from 116 species, including edentulous and enamel-less mammals, then evolutionary analyses were implemented. The results showed that variant ORF-disrupting mutations have been detected in ACPT coding region among nine edentulous baleen whales and three enamel-less taxa (pygmy sperm whale, aardvark, nine-banded armadillo). Furtherly, selective pressure uncovered that the selective constraints have been relaxed among all toothless and enamel-less lineages. Moreover, our results support the hypothesis that mineralized teeth were lost or degenerated in the common ancestor of crown Mysticeti through two shared single-base sites deletion in exon 4 and 5 of ACPT among all living baleen whales. DN / dS values on transitional branches were used to estimate ACPT inactivation times. In the case of aardvark, inactivation of ACPT was estimated at ~23.60-28.32 Ma, which is earlier than the oldest pangolin fossil time (Orycteropus minutus, ~19Ma), suggesting that ACPT inactivation may result in degeneration or loss of enamel. Conversely, the inactivation time of ACPT estimated in armadillo (~10.18-11.30 Ma) is later than the oldest fossil time, suggesting that inactivation of ACPT may result from degeneration or loss of enamel in these mammals. Our findings suggested that different mechanisms of degeneration of tooth / enamel might exist among toothless and enamel-less lineages during evolution. Our study further considered that ACPT is a novel gene for studying tooth evolution.
Different detection capabilities by mycological media for Candida isolates from mono- or dual-species cultures
Authors: Angelis Giulia De , Menchinelli Giulia , Torelli Riccardo , Carolis Elena De , Posteraro Patrizia , Sanguinetti Maurizio , Posteraro Brunella 
Published: December 2019

ABSTRACTObjectivesThe aim of this study was to compare the Candida bromcresol green (BCG) medium with the chromogenic (CHROM) Brilliance Candida agar and Sabouraud dextrose agar (SDA) media in regard to their capability of detecting Candida isolates from mono-or dual-species cultures.MethodsWe prepared Candida isolates’ suspensions to obtain mono-species (n = 18) or dual-species (n = 153) culture plates per each medium, and three readers independently observed 513 plates at 24-h, 48-h and 72-h incubation time. We scored reading results as correct, over or under detection compared to the expected species number(s).ResultsBCG showed significantly higher correct-detection and lower under-detection rates for all Candida species when observed by at least one reader. At 24-h reading, 12 mono-species cultures had correct (or over) detections in all media, whereas 106, 60 and 78 dual-species cultures had correct (or over) detections in BCG, CHROM or SDA, respectively.ConclusionBCG provides the basis for an accurate laboratory diagnosis of Candida infections.
Neural habituation enhances novelty detection: an EEG study of rapidly presented words
Authors: Jacob Len P. L. , Huber David E. 
Published: December 2019

AbstractHuber and O’Reilly (2003) proposed that neural habituation aids perceptual processing, separating neural responses to currently viewed objects from recently viewed objects. However, synaptic depression has costs, producing repetition deficits. Prior work confirmed the transition from repetition benefits to deficits with increasing duration of a prime object, but the prediction of enhanced novelty detection was not tested. The current study examined this prediction with a same/different word priming task, using support vector machine (SVM) classification of EEG data, ERP analyses focused on the N400, and dynamic neural network simulations fit to behavioral data to provide a priori predictions of the ERP effects. Subjects made same/different judgements to a response word in relation to an immediately preceding brief target word; prime durations were short (50ms) or long (400ms), and long durations decreased P100/N170 responses to the target word, suggesting that this manipulation increased habituation. Following long duration primes, correct “different” judgments of primed response words increased, evidencing enhanced novelty detection. An SVM classifier predicted trial-by-trial behavior with 66.34% accuracy on held-out data, with greatest predictive power at a time pattern consistent with the N400. The habituation model was augmented with a maintained semantics layer (i.e., working memory) to generate behavior and N400 predictions. A second experiment used response-locked ERPs, confirming the model’s assumption that residual activation in working memory is the basis of novelty decisions. These results support the theory that neural habituation enhances novelty detection, and the model assumption that the N400 reflects updating of semantic information in working memory.
Influence of job stress on job satisfaction among younger bank employees in China
Authors: Wu Xiaoyu 
Published: December 2019

PurposeThis study aims to examine distinct influences of two dimension job stress on job satisfaction and the moderating effects of guanxi-oriented attitude on the relationship between job stress and job satisfaction under cognitive appraisal theory and transactional theory.Design/methodology/approachIn this study, surveys are conducted among state-owned younger bank employees. The author uses the scale of job challenge stress and hindrance stress developed among Chinese younger bank employees to measure the two dimension job stress. After demonstrating guanxi-relative concepts, the moderating effects of guanxi-oriented attitude are examined in this study.FindingsThe results demonstrate that guanxi-oriented attitude does not significantly moderate the influence of challenge stress on job satisfaction, while it significantly moderates the noxious influence of hindrance stress on job satisfaction. Theoretical contributions are also discussed.Originality/valueFirst, this study suggests specific procedures to conduct hierarchical regression analysis and confirms the effects by parameters. It also proposes and summarizes specific procedures on how to calculate regression equations and draw regression lines to check the interaction received from the hierarchical regression analysis visually. Second, based on cognitive appraisal theory, guanxi-oriented attitude, a Chinese indigenous cognitive concept, was verified in this study. According to the importance of guanxi in Chinese society, the paper shows that employees who value guanxi more will buffer the noxious effects of job stress. Trainings and counseling should be designed to regulate the normal guanxi-oriented-related cognition.
Governance and coordination in health care: organic processes and structural capacity
Authors: Nugus Peter , Denis Jean-Louis , Chênevert Denis 
Published: December 2019

Purpose
The purpose of this paper is to articulate cutting-edge conceptions of the relationship between local processes in the here-and-now, and the broader influences on those processes, that are both organic and overtly designed, and to discern the implications of this relationship for future research, policy and practice.

Design/methodology/approach
A focused and structured approach was taken to give effect to this purpose by reviewing the chosen articles in this collection, which from the 2018 Organizational Behavior in Health Care conference papers.

Findings
Research in coordination within and across health care boundaries increasingly recognizes: the multilevel influences on human action and interaction in health care delivery; the challenge of balancing individual or local agency with overt interventions; the everchanging the local circumstances of healthcare delivery; and the need to foster reflexivity, that is, self-improvement capacity, in healthcare organizations.

Research limitations/implications
Interventions to improve care coordination must be grounded in the reality of changing local circumstances and incentives for action from the broader environment.

Originality/value
This paper articulates the implied tension in health care delivery between individual and local agency, and imposed structures that may contradict, but are at the same time necessary, to foster such agency.
An adaptive model predictive approach for automated vehicle control in fallback procedure based on virtual vehicle scheme
Authors: Xue Wei , Zheng Rencheng , Yang Bo , Wang Zheng , Kaizuka Tsutomu , Nakano Kimihiko 
Published: December 2019

Purpose
Automated driving systems (ADSs) are being developed to avoid human error and improve driving safety. However, limited focus has been given to the fallback behavior of automated vehicles, which act as a fail-safe mechanism to deal with safety issues resulting from sensor failure. Therefore, this study aims to establish a fallback control approach aimed at driving an automated vehicle to a safe parking lane under perceptive sensor malfunction.

Design/methodology/approach
Owing to an undetected area resulting from a front sensor malfunction, the proposed ADS first creates virtual vehicles to replace existing vehicles in the undetected area. Afterward, the virtual vehicles are assumed to perform the most hazardous driving behavior toward the host vehicle; an adaptive model predictive control algorithm is then presented to optimize the control task during the fallback procedure, avoiding potential collisions with surrounding vehicles. This fallback approach was tested in typical cases related to car-following and lane changes.

Findings
It is confirmed that the host vehicle avoid collision with the surrounding vehicles during the fallback procedure, revealing that the proposed method is effective for the test scenarios.

Originality/value
This study presents a model for the path-planning problem regarding an automated vehicle under perceptive sensor failure, and it proposes an original path-planning approach based on virtual vehicle scheme to improve the safety of an automated vehicle during a fallback procedure. This proposal gives a different view on the fallback safety problem from the normal strategy, in which the mode is switched to manual if a driver is available or the vehicle is instantly stopped.