bluuebunny/crossref_metadata_2025_split huggingface dataset:
Childhood and adolescent mental health of NICU graduates: an observational study
Authors: Chiorean Andreea , Savoy Calan , Beattie Karen , el Helou Salhab , Silmi Maysoon , Van Lieshout Ryan J 
Published: January 2020

ObjectiveTo investigate the mental health of children and adolescents admitted to neonatal intensive/special care units (NICUs) in infancy.MethodsThis cross-sectional study used a provincially representative cohort from the 2014 Ontario Child Health Study. Parents provided data on psychiatric disorders using the MINI International Neuropsychiatric Interview for Children and Adolescents in 3141 children aged 4–11 years (NICU n=389; control n=2752) and in 2379 children aged 12–17 years (NICU n=298; control n=2081). Additionally, 2235 adolescents aged 12–17 years completed the interview themselves (NICU n=285; control n=1950). Odds of psychiatric disorder were compared in those admitted and controls.ResultsBased on parent reports, NICU graduates aged 4–11 years had increased adjusted ORs (95% CI) of 1.78 (1.39 to 2.28) for any psychiatric disorder, with a marginal prevalence of 32.4% in NICU participants and 27.6% in controls. At this age, NICU graduates also had increased ORs of 1.74 (1.25 to 2.40) for psychiatric comorbidity, 1.48 (1.04 to 2.11) for oppositional defiant disorder, 1.61 (1.19 to 2.19) for attention-deficit hyperactivity disorder, 4.11 (2.33 to 7.25) for separation anxiety disorder and 2.13 (1.37 to 3.31) for specific phobia. At 12–17 years, 40.5% and 30.5% of NICU graduates and 30.6% and 17.9% of controls had any psychiatric disorder as reported by parents and self-report, respectively. Parents and adolescents, respectively, reported increased adjusted ORs (95% CI) of 1.63 (1.18 to 2.26) and 1.55 (1.13 to 2.11) for any disorder, 1.64 (1.06 to 2.54) and 1.74 (1.11 to 2.73) for psychiatric comorbidity, and 1.89 (1.22 to 2.93) and 3.17 (2.03 to 4.95) for oppositional defiant disorder.ConclusionsNICU graduates are at increased risk for psychiatric disorders during childhood and adolescence.
Evaluation of contrast sensitivity in patients with advanced glaucoma: comparison of two tests
Authors: Jammal Alessandro A , Ferreira Bruna G , Zangalli Camila S , Vianna Jayme R , Thompson Atalie C , Artes Paul H , Costa Vital P , Reis Alexandre S C 
Published: January 2020

AimsTo evaluate contrast sensitivity (CS) in patients with advanced glaucomatous visual field damage, and to compare two clinical CS tests.MethodsThis was a cross-sectional test–retest study. Twenty-eight patients with open-angle glaucoma, visual acuity (VA) better than 20/40 and visual field mean deviation (MD) worse than −15 dB were enrolled. Patients underwent VA, visual field and CS testing with the Pelli-Robson (PR) chart and the Freiburg Visual Acuity and Contrast Test (FrACT). Retest measurements were obtained within 1 week to 1 month.ResultsMedian (IQR) age and MD were 61.5 (55.5 to 69.2) years and −27.7 (−29.7 to −22.7) dB, respectively. Median (IQR) VA was 0.08 logarithm minimum angle of resolution (0.02 to 0.16), corresponding to 20/25 (20/20 to 20/30). Median (IQR) CS was 1.35 (1.11 to 1.51) log units with the PR chart and 1.39 (1.24 to 1.64) log units with FrACT. VA explained less than 40% of the variance in CS (adjusted R2=0.36). CS estimates of both tests were closely related (rho=0.88, p=0.001), but CS was 0.09 log units higher with FrACT compared with the PR chart, and the 95% repeatability intervals (Bland-Altman) were 46% tighter with the PR chart.ConclusionsDespite near-normal VA, almost all patients showed moderate to profound deficits in CS. CS measurement provides additional information on central visual function in patients with advanced glaucoma.
Modelling the annual NHS costs and outcomes attributable to healthcare-associated infections in England
Authors: Guest Julian F , Keating Tomas , Gould Dinah , Wigglesworth Neil 
Published: January 2020

ObjectivesTo estimate the annual health economic impact of healthcare-associated infections (HCAIs) to the National Health Service (NHS) in England.DesignA modelling study based on a combination of published data and clinical practice.SettingNHS hospitals in England.Primary and secondary outcome measuresAnnual number of HCAIs, additional NHS cost, number of occupied hospital bed days and number of days front-line healthcare professionals (HCPs) are absent from work.ResultsIn 2016/2017, there were an estimated 653 000 HCAIs among the 13.8 million adult inpatients in NHS general and teaching hospitals in England, of which 22 800 patients died as a result of their infection. Additionally, there were an estimated 13 900 HCAIs among 810 000 front-line HCPs in the year. These infections were estimated to account for a total of 5.6 million occupied hospital bed days and 62 500 days of absenteeism among front-line HCPs. In 2016/2017, HCAIs were estimated to have cost the NHS an estimated £2.1 billion, of which 99.8% was attributable to patient management and 0.2% was the additional cost of replacing absent front-line HCPs with bank or agency staff for a period of time. When the framework of the model was expanded to include all NHS hospitals in England (by adding specialist hospitals), there were an estimated 834 000 HCAIs in 2016/2017 costing the NHS £2.7 billion, and accounting for 28 500 patient deaths, 7.1 million occupied hospital bed days (equivalent to 21% of the annual number of all bed days across all NHS hospitals in England) and 79 700 days of absenteeism among front-line HCPs.ConclusionThis study should provide updated estimates with which to inform policy and budgetary decisions pertaining to preventing and managing these infections. Clinical and economic benefits could accrue from an increased awareness of the impact that HCAIs impose on patients, the NHS and society as a whole.
Patient satisfaction and associated factors among psychiatry outpatients of St Paulo’s Hospital, Ethiopia
Authors: Goben Kebebew Wogi , Abegaz Endalamaw Salelew , Abdi Samuel Tolesa 
Published: January 2020

BackgroundPatient satisfaction with mental healthcare service is recognised as an important integral part of measuring the outcomes and performance of clinical service delivery. It is not well studied in Ethiopia. Therefore, it is essential to improve service in the future.AimsTo assess patient satisfaction and associated factors among psychiatry outpatients at St. Paulo’s Hospital Millennium Medical College, Addis Ababa, Ethiopia.MethodsAn institutional-based cross-sectional study was conducted with consecutive sampling technique from May to June 2018. Data were collected using a Client Satisfaction Questionnaire (CSQ-8). Both bivariate and multivariate ordinal logistic regression analyses were used. Variables with p value <0.05 at multivariate analysis were considered statistically significant.ResultsA total of 589 participants were enrolled with a response rate of 98.2%. In regard to the magnitude of patient satisfaction, 50.3% (95% CI 46.0 to 54.2) were highly satisfied, 31.0% (95% CI 27.2 to 34.8) were satisfied, and 18.7% (95% CI 15.4 to 22.1) were dissatisfied. Male sex (adjusted OR (AOR) 2.30, 95% CI 1.57 to 3.36), inability to read and write (AOR 2.23, 95% CI 1.10 to 4.66), being unemployed (AOR 1.69, 95% CI 1.15 to 2.47), obtaining services for free (AOR 1.57, 95% CI 1.11 to 2.22), and availability of medication (AOR 1.62, 95% CI 1.13 to 2.23) were significantly associated with patient satisfaction.ConclusionsThe study showed that further improvements in patient satisfaction are required. Male sex, inability to read and write, being unemployed, obtaining services free of charge, and availability of medication were significantly associated with patient satisfaction. More than half of the participants were dissatisfied with the waiting time to receive services. The provision of services within a reasonable timeframe and meeting patient expectations are helpful for good health outcomes.
Gastric microbes associated with gastric inflammation, atrophy and intestinal metaplasia 1 year afterHelicobacter pylorieradication
Authors: Sung Joseph J Y , Coker Olabisi Oluwabukola , Chu Eagle , Szeto Chun Ho , Luk Simson Tsz Yat , Lau Harry Cheuk Hay , Yu Jun 
Published: January 2020

ObjectiveHelicobacter pyloriis associated with gastric inflammation, precancerous gastric atrophy (GA) and intestinal metaplasia (IM). We aimed to identify microbes that are associated with progressive inflammation, GA and IM 1 year afterH. pylorieradication.DesignA total of 587 H. pylori–positive patients were randomised to receiveH. pylorieradication therapy (295 patients) or placebo (292 patients). Bacterial taxonomy was analysed on 404 gastric biopsy samples comprising 102 pairs before and after 1 yearH. pylorieradication and 100 pairs before and after 1 year placebo by 16S rRNA sequencing.ResultsAnalysis of microbial sequences confirmed the eradication ofH. pyloriin treated group after 1 year. Principal component analysis revealed distinct microbial clusters reflected by increase in bacterial diversity (p<0.00001) afterH. pylorieradication. While microbial interactions remained largely unchanged after placebo treatment, microbial co-occurrence was less in treated group.Acinetobacter lwoffii,Streptococcus anginosusandRalstoniawere enriched whileRoseburiaandSphingomonaswere depleted in patients with persistent inflammation 1 year afterH. pylorieradication. A distinct cluster of oral bacteria comprisingPeptostreptococcus,Streptococcus,Parvimonas,Prevotella, RothiaandGranulicatellawere associated with emergence and persistence of GA and IM. ProbioticFaecalibacterium praustzniiwas depleted in subjects who developed GA followingH. pylorieradication. Functional pathways including amino acid metabolism and inositol phosphate metabolism were enriched while folate biosynthesis and NOD-like receptor signalling decreased in atrophy/IM-associated gastric microbiota.ConclusionThis study identified that gastric microbes contribute to the progression of gastric carcinogenesis afterH. pylorieradication.
Change in device-measured physical activity assessed in childhood and adolescence in relation to depressive symptoms: a general population-based cohort study
Authors: Hamer Mark , Patalay Praveetha , Bell Steven , Batty G David 
Published: January 2020

AimEvidence for a link between physical activity and mental health in young people is hampered by methodological shortcomings. Using repeat assessments of device-measured physical activity, we examined the association of within-individual variation in free-living activity over 7 years with depressive symptoms.MethodsThis was a prospective cohort study of a nationally representative sample of children born in the UK (n=4898). Physical activity was quantified using accelerometry at ages 7 and 14. The main outcome was depressive symptoms, based on the Short Mood and Feelings Questionnaire, assessed at age 14.ResultsAfter adjustment for socioeconomic status, body mass index and psychological problems at baseline, a higher level of light-intensity activity at age 7 in girls was associated with a lower likelihood of having depressive symptoms at follow-up (OR, 0.79; 95% CI 0.61 to 1.00), although no associations were observed for moderate to vigorous activity or sedentary behaviour. Girls who transitioned from low baseline activity to higher levels at follow-up experienced a lower risk of depressive symptoms (OR, 0.60; 95% CI 0.39 to 0.92) compared with the inactive reference category. Null associations were observed in boys. Participants who consistently met the current recommendation of 60 min/day of moderate to vigorous activity both at 7 and 14 years of age experienced the lowest risk of depressive symptoms (OR, 0.55; 95% CI 0.34 to 0.88).ConclusionTo prevent depressive symptoms in adolescence, policies to increase physical activity from mid-childhood may have utility.
Lifetime cumulative exposure to rubber dust, fumes and N-nitrosamines and non-cancer mortality: a 49-year follow-up of UK rubber factory workers
Authors: Hidajat Mira , McElvenny Damien Martin , Ritchie Peter , Darnton Andrew , Mueller William , Agius Raymond M , Cherrie John W , de Vocht Frank 
Published: January 2020

ObjectivesTo examine associations between occupational exposures to rubber dust, rubber fumes and N-nitrosamines and non-cancer mortality.MethodsA cohort of 36 441 males aged 35+ years employed in British rubber factories was followed-up to 2015 (94% deceased). Competing risk survival analysis was used to assess risks of dying from non-cancer diseases (respiratory, urinary, cerebrovascular, circulatory and digestive diseases). Occupational exposures to rubber dust, rubber fumes, N-nitrosamines were derived based on a population-specific quantitative job-exposure matrix which in-turn was based on measurements in the EU-EXASRUB database.ResultsExposure–response associations of increased risk with increasing exposure were found for N-nitrosomorpholine with mortality from circulatory diseases (subdistribution hazard ratio (SHR) 1.17; 95% CI 1.12 to 1.23), ischaemic heart disease (IHD) (SHR 1.19; 95% CI 1.13 to 1.26), cerebrovascular disease (SHR 1.19; 95% CI 1.07 to 1.32) and exposures to N-nitrosodimethylamine with respiratory disease mortality (SHR 1.41; 95% CI 1.30 to 1.53). Increased risks for mortality from circulatory disease, IHD and digestive diseases were found with higher levels of exposures to rubber dust, rubber fumes and N-nitrosamines sum, without an exposure-dependent manner. No associations were observed between rubber dust, rubber fumes and N-nitrosamines exposures with mortality from asthma, urinary disease, bronchitis, emphysema, liver disease and some digestive diseases.ConclusionsIn a cohort of rubber factory workers with 49 years of follow-up, increased risk for mortality from circulatory, cerebrovascular, respiratory and digestive diseases were found to be associated with cumulative occupational exposures to specific agents.
Serum melatonin in dogs with congenital portosystemic shunting, with and without hepatic encephalopathy
Authors: Ferreira Marisa da Fonseca , Mellanby Richard John , Gow Adam George 
Published: January 2020

BackgroundMelatonin is a hormone produced and secreted primarily by the pineal gland and mainly metabolised in the liver. Increased melatonin concentrations have been reported in human cirrhosis and hepatic encephalopathy (HE), a syndrome of neurological dysfunction. The pathogenesis of canine HE is incompletely understood. Melatonin has been hypothesised as a contributor to the development of HE. The aim of this study was to investigate whether serum melatonin concentrations are increased in canine congenital portosystemic shunting (cPSS), with and without HE.MethodsMedical records were retrospectively reviewed, for which archived (−80°C) serum samples were available. A canine competitive ELISA was used to measure melatonin in two cohorts: dogs with a final diagnosis of cPSS (n=23) with and without clinical signs of HE, and healthy dogs (n=15).ResultsMelatonin concentrations were not significantly different (P=0.81) between healthy controls (median 27.2 pg/mL, range 19.8–161.5 pg/mL) and dogs with cPSS (median 25.7 pg/mL, range 18.5–244.9 pg/mL). Serum melatonin did not differ between cPSS patients with and without clinical signs of HE (P>0.99). No correlation was found between serum melatonin and blood ammonia (Spearman rank correlation coefficient,rs=−0.41, P=0.08).ConclusionSerum melatonin is not increased in canine cPSS with and without HE. We found no evidence that altered melatonin metabolism plays a role in the pathogenesis of cPSS‐associated HE.
Randomised clinical non‐inferiority trial comparing two formulations of desoxycortone pivalate for the treatment of canine primary hypoadrenocorticism
Authors: Farr Hayley , Mason Beasley L , Longhofer Susan L 
Published: January 2020

BackgroundThis clinical trial compared two formulations of desoxycortone pivalate (DOCP) for treating the mineralocorticoid deficit in dogs with primary hypoadrenocorticism (PH).MethodsAt veterinary clinics in the USA and France, dogs with PH (n=152) were randomised (3:1) to receive approximately monthly treatments with either the test product, Zycortal (Dechra), administered subcutaneously (n=113), or the control product, Percorten‐V (Novartis Animal Health), administered intramuscularly (n=39), both at an initial dose of 2.2 mg/kg DOCP. Treatment administrators were unblinded; veterinarians assessing clinical signs were blinded; owners were blinded until at least day 90, the primary end point. Veterinarians assessed treatment outcome based on all of the following: clinical signs; sodium concentrations; potassium concentrations. Dogs received concurrent glucocorticoid therapy throughout the trial. Non‐inferiority was assessed using a generalised linear mixed model to compare success rates between groups.ResultsSuccess rates at day 90 were similar between groups (per‐protocol population at day 90: Zycortal 87/101, 86.2 per cent, Percorten‐V 29/34, 85.1 per cent). Zycortal was non‐inferior to Percorten‐V as the upper limit of the 95 per cent CI for the difference between groups was 13.6 per cent. Polydipsia and polyuria were the most common clinical observations.ConclusionBoth products, in combination with glucocorticoid therapy, were safe and effective in treating PH.
Neutrophilia is associated with a poorer clinical outcome in dogs with chronic hepatitis
Authors: Breheny Craig R , Handel Ian , Banner Stephanie , Milne Elspeth M , Morrison Linda R , Smith Sionagh H , Kilpatrick Scott , Gow Adam , Mellanby Richard J 
Published: January 2020

BackgroundLiver disease is a common cause of morbidity and mortality in dogs. Currently, it is challenging to prognosticate in these cases. The aim of this study was to evaluate the utility of the haematological variables in dogs with chronic hepatitis.MethodsDogs with chronic hepatitis confirmed on histopathology had presenting haematological values retrospectively obtained and evaluated against survival time. Eighty‐two dogs met the inclusion criteria and their data analysed.ResultsNeutrophilic patients, with a count greater than 12×109 /l, controlled for sex and age, had a shorter survival time (P≤0.01). In dogs, neutrophilia at presentation predicted a poor outcome, whereas the other haematological parameters were not prognostically informative. When the dogs were split into even quarters on the basis of their neutrophil count, those within the higher quartiles had poorer survival times. Neutrophilia was associated with a poorer survival time in comparison to those patients with a lower count.ConclusionThe relationship between neutrophils, inflammation and clinical outcome is deserving of future study in dogs with chronic hepatitis.
Hair nicotine concentration of cats with gastrointestinal lymphoma and unaffected control cases
Authors: Smith Victoria , Knottenbelt Clare , Watson David , Mellor Dominic J , Guillen Martinez Alexandra , Philp Helen , Keegan Sarah , Marrington Mary , Giannasi Chiara , Cave Tom , McBrearty Alix Rebecca 
Published: January 2020

BackgroundA previous study showed an association between owner‐reported exposure to environmental tobacco smoke (ETS) and lymphoma in cats. This study aimed to investigate the association between ETS exposure and gastrointestinal lymphoma in cats, using hair nicotine concentration (HNC) as a biomarker.MethodsThis was a prospective, multi‐centre, case–control study. Gastrointestinal lymphoma was diagnosed on cytology or histopathology. Hair samples were obtained from 35 cats with gastrointestinal lymphoma and 32 controls. Nicotine was extracted from hair by sonification in methanol followed by hydrophilic interaction chromatography with mass spectrometry. Non‐parametric tests were used.ResultsThe median HNC of the gastrointestinal lymphoma and control groups was not significantly different (0.030 ng/mg and 0.029 ng/mg, respectively, p=0.46). When the HNC of all 67 cats was rank ordered and divided into quartiles, there was no significant difference in the proportion of lymphoma cases or controls within these groups (p=0.63). The percentage of cats with an HNC≥0.1 ng/mg was higher for the lymphoma group (22.9%) than the control group (15.6%) but failed to reach significance (p=0.45).ConclusionA significant association was not identified between HNC (a biomarker for ETS) and gastrointestinal lymphoma in cats; however, an association may exist and further studies are therefore required.
Molecular $$\Xi _{bc}$$ states from meson–baryon interaction
Authors: Yu Qi-Xin , Dias J. M. , Liang Wei-Hong , Oset E. 
Published: January 2020

AbstractWe have studied the meson–baryon interaction in coupled channels with the same quantum numbers of $$\Xi _{bc}$$Ξbc. The interaction is attractive in some channels and of sufficient intensity to lead to bound states or resonances. We use a model describing the meson–baryon interaction based on an extrapolation of the local hidden gauge approach to the heavy sector, which has been successfully used in predicting $$\Omega _c$$Ωc and hidden charm states. We obtain many states, some of them narrow or with zero width, as a consequence of the interaction, which qualify as molecular states in those channels. The success in related sectors of the picture used should encourage the experimental search for such states.
Semilinear fractional stochastic differential equations driven by a γ-Hölder continuous signal with γ > 2/3
Authors: León Jorge A. , Márquez-Carreras David 
Published: January 2020

In this paper, we use the techniques of fractional calculus to study the existence of a unique solution to semilinear fractional differential equation driven by a [Formula: see text]-Hölder continuous function [Formula: see text] with [Formula: see text]. Here, the initial condition is a function that may not be defined at zero and the involved integral with respect to [Formula: see text] is the extension of the Young integral [An inequality of the Hölder type, connected with Stieltjes integration, Acta Math. 67 (1936) 251–282] given by Zähle [Integration with respect to fractal functions and stochastic calculus I, Probab. Theory Related Fields 111 (1998) 333–374].
ACM SIGSOFT International Workshop on Software-Intensive Business
Authors: Smolander Kari , Grünbacher Paul , Hyrynsalmi Sami , Jansen Slinger 
Published: January 2020

ACM SIGSOFT International Workshop on Software-intensive Business: Start-ups, Platforms and Ecosystems (IWSiB 2019) was hosted by ESEC/FSE 2019 and it was held in Tallinn in August 2019. The workshop was motivated by a preceding Dagstuhl Seminar 18182 in which the participants agreed on founding of a workshop series for promoting and advancing the research of software-intensive business.
This workshop paid special attention on the four modern themes of software- intensive business: engineering for software business, software ecosystems, education and software business, and software as a service. This report briefly presents the insights from discussions, presented studies and keynotes.