bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improvement of interfacial adhesion and mechanical properties of sisal fiber‐reinforced poly(lactic acid) composites with added bisoxazoline
Authors: Zhanglin Lv , Hong wu Wu , Yunmeng Pei , Bi Lan 
Published: January 2020

AbstractIn order to improve interfacial adhesion between poly(lactic acid) (PLA) and sisal fibers (SFs), bifunctional monomer bisoxazoline (BO) was introduced into melt‐blending process of fibers reinforced PLA composites via in situ reactive interfacial compatibilization. The morphology of fibers and their reinforced PLA composites, thermal, and mechanical properties of the composites were studied. Fourier transform infrared spectroscopy (FTIR) and scanning electron microscope (SEM) results confirmed that PLA was successfully grafted onto the surface of fiber. BO played a hinge‐like role between PLA molecular chains and SFs. The interfacial reaction and the microstructures of the SF‐reinforced PLA composites were investigated by thermal analysis. The cold crystallization temperature of the composites increased by 6.5°C with the addition of 0.6 wt% BO and 20 wt% SF as compared with the composites without BO. Microdebonding test further confirmed that interfacial shear strength of samples with BO increased by more than 30.7% in comparison with unmodified samples. For composites with 20 wt% SF addition, tensile strength and modulus increased by 34% and 10%, respectively, with 1 wt% BO addition. Flexural strength and modulus increased by 25% and 8%, respectively, with the addition of 1.2 wt% BO. Impact strength of 1 wt% BO‐modified composites was 5.1 MPa, which is 17% higher than that of the composites without BO.
Mercy TAPE for Calculation‐Free Height Estimation in Pediatric Rehabilitation Patients
Authors: Modrcin Ann C. , Luce John , Abdel‐Rahman Susan M. 
Published: January 2020

BackgroundIn children, height is an essential element of a pediatric assessment, yet this measure is less likely to occur in nonambulatory children or those with unique disabilities. There is compelling support for surrogate measures; however, many of these are accompanied by limitations.ObjectiveThis study was conducted to evaluate whether the U.S. Food and Drug Administration (FDA)–cleared Mercy TAPE could be adopted for height estimation.DesignDevelopment and external validation of a height‐estimation method were conducted with retrospectively collected data in nonrehabilitation children. Testing of the model was performed prospectively in a pediatric rehabilitation population.SettingU.S. pediatric rehabilitation outpatient clinic.ParticipantsData from 19 407 children were used to develop the model. Data from an independent cohort of 1472 children were used for external validation, and the model was tested in 195 pediatric rehabilitation patients. Of the 195 patients, 57% required no wheelchair, 18% could ambulate independently for short distances, 17% could ambulate with an assistive device, and 8% were full‐time wheelchair users.InterventionsNot applicable.Main Outcome MeasurementsRelative error (RE), percentage error (PE), and percent predicted within 10% and 20% of actual height.ResultsHeight estimated with the modified Mercy TAPE was highly predictive of actual height in nonrehabilitation children in the United States (RE [mean ± SD]: 1.1 ± 5.7 cm; PE [mean ± SD]: 1.0 ± 4.7%). In rehabilitation patients, height was underestimated to a greater extent (RE [mean ± SD]: 3.0 ± 7.4 cm; PE [mean ± SD]: −2.1 ± 5.6%).ConclusionsThe Mercy TAPE offers a reasonable approximation of height in ambulatory children, although it slightly underestimates height in the pediatric rehabilitation population. Consequently, this and other surrogate measures may be less suited to examining growth against a reference ambulatory population and more suited to following individual children over time.
Entry diversion: Deterrence by diverting submarket entry
Authors: Uzunca Bilgehan , Cassiman Bruno 
Published: January 2020

AbstractResearch SummaryGoing back to Bain (1956), strategy scholars have long recognized the importance of deterring entry for sustaining incumbents' profits in an industry. We introduce a new mechanism, entry diversion, to better understand the empirical phenomenon of persistent firm entry in spite of investments in entry deterrence by incumbents in some industries. Entry diversion happens when preemptive strategic investments by incumbents decrease the expected future profits from a target submarket such that entrants choose to enter another submarket within the same industry. Empirical evidence from the global semiconductor manufacturing industry suggests that incumbents expand their capacities beyond demand growth, and that these investments effectively divert entry into other submarkets. Greenfield entrants are more responsive to entry diversion than incumbents.Managerial SummaryManagers have long understood that deterring entry of new players into their industry could sustain their firms' profits. In this article, we introduce a new mechanism, entry diversion, where the incumbent diverts potential entrants from its submarket toward other submarkets in the same industry. Entry diversion happens when preemptive strategic investments by incumbents decrease the expected future profits of the entrant in a submarket of the industry such that the entrant chooses not to enter the incumbent's submarket. Contrary to entry deterrence, new players will still enter the industry but settle in different submarkets. Empirical evidence from the global semiconductor manufacturing industry suggests that incumbents expand their capacities beyond demand growth, and that these investments effectively divert entry into other submarkets.
Considerations in Developing Reporter Gene Bioassays for Biologics
Authors: Grailer Jamison , Moravec Richard A. , Cheng Zhijie Jey , Grassi Manuela , Ott Vanessa , Fan Frank , Cong Mei 
Published: January 2020

AbstractThe establishment of a robust and reproducible functional bioassay that reliably measures drug potency while ascertaining its mode of action is essential in biologic drug development. Here we describe a simple bioluminescent reporter gene bioassay for assessing biologics targeting immune checkpoints without the complexity and variability of more traditional assay systems. This chapter provides an overview of key considerations in reporter gene bioassay design and optimization, as well as development of thaw-and-use cells as an assay reagent for biologic QC lot release.
Decreases in the Psoas Muscle Index Correlate More Strongly with Survival than Other Prognostic Markers in Esophageal Cancer After Neoadjuvant Chemoradiotherapy Plus Esophagectomy
Authors: Kawakita Yuta , Motoyama Satoru , Sato Yusuke , Wakita Akiyuki , Nagaki Yushi , Imai Kazuhiro , Minamiya Yoshihiro 
Published: January 2020

AbstractBackgroundDespite wide acknowledgement of the importance of sarcopenia and prognostic markers such as the neutrophil‐to‐lymphocyte ratio, the impact on cancer patient survival of the timing of sarcopenia's emergence and its severity is not well understood, nor is the association between sarcopenia and prognostic markers. The aim of this study, therefore, was to investigate the effect of the severity and timing of changes in the psoas muscle index (PMI) on survival of advanced esophageal squamous cell carcinoma (ESCC) patients receiving neoadjuvant chemoradiotherapy (NACRT) plus esophagectomy and the association between PMI and known prognostic markers.MethodsIncluded in this study were 113 ESCC patients who underwent NACRT followed by esophagectomy. PMI and prognostic markers were measured at their initial visit, just before surgery (after NACRT), and 3 months postoperatively.ResultsAll patients were classified into four groups according to the percent decrease in PMI after NACRT and after NACRT plus esophagectomy. Patients exhibiting a larger PMI decrease (≥20%) after NACRT plus esophagectomy had significantly poorer overall survival than those showing a smaller PMI decrease. Furthermore, multivariable analysis showed that a larger decrease in PMI after NACRT plus esophagectomy was a significant risk factor for overall (P < 0.0001) and recurrence‐free (P = 0.0097) survival. Neither pretherapeutic PMI nor a decrease in PMI after NACRT significantly affected survival. PMI also showed weak, but significant, correlations with several prognostic markers postoperatively.ConclusionsDecreased PMI after NACRT plus esophagectomy is a strong prognostic indicator in ESCC patients.
An inverse optimization approach to understand human acquisition of kinematic coordination in bimanual fine manipulation tasks
Authors: Yao Kunpeng , Billard Aude 
Published: January 2020

AbstractTasks that require the cooperation of both hands and arms are common in human everyday life. Coordination helps to synchronize in space and temporally motion of the upper limbs. In fine bimanual tasks, coordination enables also to achieve higher degrees of precision that could be obtained from a single hand. We studied the acquisition of bimanual fine manipulation skills in watchmaking tasks, which require assembly of pieces at millimeter scale. It demands years of training. We contrasted motion kinematics performed by novice apprentices to those of professionals. Fifteen subjects, ten novices and five experts, participated in the study. We recorded force applied on the watch face and kinematics of fingers and arms. Results indicate that expert subjects wisely place their fingers on the tools to achieve higher dexterity. Compared to novices, experts also tend to align task-demanded force application with the optimal force transmission direction of the dominant arm. To understand the cognitive processes underpinning the different coordination patterns across experts and novice subjects, we followed the optimal control theoretical framework and hypothesize that the difference in task performances is caused by changes in the central nervous system’s optimal criteria. We formulated kinematic metrics to evaluate the coordination patterns and exploit inverse optimization approach to infer the optimal criteria. We interpret the human acquisition of novel coordination patterns as an alteration in the composition structure of the central nervous system’s optimal criteria accompanied by the learning process.
Adolescent Sexual Behavior Patterns in a British Birth Cohort: A Latent Class Analysis
Authors: Xu Yin , Norton Sam , Rahman Qazi 
Published: January 2020

AbstractThis study examined adolescent sexual behaviors patterns, and the consistency between sexual behavior and sexual orientation, in a prospective birth cohort. We used data on 5150 young people from the Avon Longitudinal Study of Parents and Children. Sexual orientation was assessed using a 5-point scale of sexual attraction at 15.5 years. Fourteen sexual activities were assessed using the Adolescent Sexual Activities Index at 13.5 and 15.5 years. Latent class analysis suggested four subgroups of adolescent sexual behaviors at 13.5: a “high-intensity sexual behaviors exclusively with other-sex, no same-sex intimacy” group (3.87%); a “moderate-intensity sexual behaviors exclusively with other-sex, no same-sex intimacy” group (16.57%); a “low-intensity sexual behaviors exclusively with other-sex, no same-sex intimacy” group (34.21%); and a “no sexual behavior” group (45.35%). There were five subgroups at 15.5 where four of them (23.42%, 18.37%, 28.12%, and 24.52%, respectively) were interpreted the same as at 13.5 years and a new “high-intensity sexual behaviors, some same-sex intimacy” subgroup (5.57%). Latent transition analysis showed approximately half the adolescents moved toward greater engagement in higher intensity sexual activities with other-sex at 15.5. Boys and girls who were in groups without same-sex intimacy were predominantly attracted to the other-sex, whereas there were moderate consistencies between same-sex intimacy and same-sex attraction for boys and low consistency for girls. Findings suggest that it may be important to include low-intensity sexual behaviors when assigning adolescents to sexual orientation groupings (via sexual behaviors) in order to reduce selection biases and increase statistical power via the increase in sample size.
Phase I dose-escalation study of the safety, tolerability, and pharmacokinetics of aflibercept in combination with S-1 in Japanese patients with advanced solid malignancies
Authors: Doi Toshihiko , Boku Narikazu , Onozawa Yusuke , Takahashi Keishiro , Kawaguchi Osamu , Ohtsu Atsushi 
Published: January 2020

SummaryBackground Aflibercept, a recombinant fusion protein binding VEGF-A, VEGF-B and placental growth factor, inhibits tumor growth by blocking angiogenesis. The aim of this phase I dose-escalation study was to determine the recommended phase II dose (RP2D) of aflibercept in combination with S-1 in Japanese patients with solid tumors. Patients and methods Sequential cohorts of 3–6 patients with metastatic or unresectable solid tumors, who had failed at least one prior line of standard treatment or who were not suitable for such treatment, were to receive escalating doses of aflibercept every 2 weeks, starting at 2 mg/kg, combined with S-1 at 40 mg/m2 twice daily (80 mg/m2/day; 4 weeks on/2 weeks off). Dose-escalation was to be based on the incidence of dose-limiting toxicity (DLT). Blood samples were collected for pharmacokinetic analysis. Results At the first dose level (aflibercept 2 mg/kg plus S-1) 1 of 6 patients experienced a DLT (grade 4 proteinuria). The aflibercept dose was consequently escalated to 4 mg/kg; 1 of 3 patients treated at this dose level had a DLT (grade 2 pleural effusion), and another patient experienced grade 3 reversible posterior leukoencephalopathy syndrome after the DLT assessment period. Additional patients were therefore enrolled into the first dose level to explore safety and tolerability. The study was subsequently terminated prematurely. The maximum tolerated dose was not reached and the RP2D was not determined in Japanese patients. Conclusions The tolerability and safety of aflibercept 2 mg/kg in combination with S-1 was confirmed in Japanese patients with advanced solid tumors.
Positive Aspects of Emotional Competence in Preventing Internalizing Symptoms in Children with and without Developmental Language Disorder: A Longitudinal Approach
Authors: Samson Andrea C. , van den Bedem Neeltje P. , Dukes Daniel , Rieffe Carolien 
Published: January 2020

AbstractIn order to better understand protective factors for internalizing problems, this longitudinal study examined positive emotions, emotion awareness and (non-)emotional communication skills in relation to somatic complaints and social anxiety in children with (N = 104) and without (N = 183) Developmental Language Disorder (DLD) using self-reported measures twice with a 9-month interval. Additionally, parents reported on their child’s communication problems and emotion communication at Time 1. Most importantly, since we found that increasing levels of emotion awareness related to decreases in social anxiety and somatic complaints in children with and without DLD, we conclude that children with DLD are likely to benefit from interventions aimed at improving their emotion awareness in addition to language interventions.
Victimization and Its Consequences for Well-Being: A Between- and Within-Person Analysis
Authors: Janssen Heleen J. , Oberwittler Dietrich , Koeber Goeran 
Published: January 2020

AbstractObjectivesWe examined the effects of victimization on several aspects of well-being in a longitudinal study of a general population sample. Previous research has often been inconclusive, as it was largely based on cross-sectional data and prone to problems of unobserved heterogeneity and selection bias. We examined both between-person differences and within-person changes in well-being in relation to property and violent victimization. We investigated psychological and behavioral dimensions of well-being, controlling for and comparing with the effects of other negative life events.MethodsWe used data from a two-wave panel survey of 2928 respondents aged 25–89 nested in 140 neighborhoods in two large German cities. We applied random-effects modeling to separate between-person from within-person effects.ResultsThe within-person detrimental effects of victimization were considerably smaller than between-person effects, which reflected preexisting, time-stable factors that distinguish individuals who have experienced victimization from individuals who have not. Detrimental effects concerned fear of crime, generalized trust, and neighborhood satisfaction, but did not extend to emotional well-being or life satisfaction, in contrast to other negative life events. We found empirical support both for adaptation (‘recovery’) effects as well as for anticipation effects. Violent victimization had stronger effects than property victimization, and victimization near the home had stronger effects than victimization elsewhere.ConclusionThe findings indicate that violent victimization has palpable detrimental effects on security perceptions, trust and neighborhood satisfaction—but not on emotional well-being and life satisfaction—and that individuals largely recover from the victimization within 18 months.
Four Dimensions of Criticism Against Gender-Fair Language
Authors: Vergoossen Hellen Petronella , Renström Emma Aurora , Lindqvist Anna , Gustafsson Sendén Marie 
Published: January 2020

AbstractThe gender-neutral third-person pronoun singular hen was recently introduced in Swedish as a complement to she (hon) and he (han). The initiative to add hen initially received strong criticism. In the present study, we analyzed 208 arguments from 168 participants with critical attitudes toward hen. We used Blaubergs’ (1980) and Parks and Roberton’s (1998) taxonomies of critical arguments against past gender-fair language reforms in English in the 1970s and 1990s as a basis for coding the arguments. A majority of arguments (80.7%) could be coded into existing categories, indicating that criticisms of gender-fair language initiatives are similar across different times and cultural contexts. Two categories of arguments did not fit existing categories (19.3%): gender-neutral pronouns are distracting in communication and gender information is important in communication. Furthermore, we established four overarching dimensions that capture assumptions and beliefs underlying gender-fair language criticism: (a) Defending the Linguistic Status Quo (39.4%), (b) Sexism and Cisgenderism (27.4%), (c) Diminishing the Issue and Its Proponents (26.9%), and (d) Distractor In Communication (6.3%). These dimensions of criticisms should be considered and addressed in different ways when implementing gender-fair language.
Exploring seagrass fish assemblages in relation to the habitat patch mosaic in the brackish Baltic Sea
Authors: Staveley Thomas A.B. , Hernvall Patrick , Stjärnkvist Nellie , van der Meijs Felix , Wikström Sofia A. , Gullström Martin 
Published: January 2020

AbstractAssessing the influence of habitat patch dynamics on faunal communities is a growing area of interest within marine ecological studies. This study sets out to determine fish assemblage composition in Zostera marina (L.) meadows and ascertain how habitat structural complexity and seascape structure (i.e. composition and configuration of habitat patches) influenced these assemblages in the northern Baltic Sea. Using ten seascapes (600 m in diameter), the fish assemblage was surveyed both in summer and autumn using beach seine. We found that the fish assemblage was clearly dominated by sticklebacks, followed by pipefish and with a general absence of larger piscivorous species. Biomass of fish did not differ between seasons, and low-level carnivores dominated the trophic structure. Overall, at the larger seascape-scale in summer, the proportion of bare soft sediment showed a negative relationship with fish biomass, while diversity of patches was found to exhibit a positive association with fish biomass. At the smaller habitat scale, both seagrass shoot height and density had a negative influence on fish biomass in both seasons. This study outlines new knowledge regarding how the mosaic of habitat patches shape seagrass fish assemblages in the northern Baltic Sea.
An integrated workflow to perform reservoir and completion parametric study on a shale gas reservoir
Authors: Mahmoud Mohamed , Aleid Ahmed , Ali Abdulwahab , Kamal Muhammad Shahzad 
Published: January 2020

AbstractThe main objectives of this paper are to assess the long-term and short-term production based on both reservoir parameters and completion parameters of shale gas reservoirs. The effects of the reservoir parameters (permeability and the initial reservoir pressure) and completion parameters (fracture geometry, stimulated reservoir volume, etc.) on the short-term and long-term production of shale gas reservoirs were investigated. The currently used approach relies mainly on the decline curve analysis or analogs from a similar shale play to forecast the gas production from shale gas reservoirs. Both these approaches are not satisfactory because they are calibrated on short production history and do not assess the impact of uncertainty in reservoir and well data. For the first time, this study integrates initial production analysis, probabilistic evaluation, and sensitivity analysis to develop a robust workflow that will help in designing a sustainable production from shale gas plays. The reservoir and completion parameters were collected from different available resources, and the probability distributions of gathered uncertain data were defined. Then analytical models were used to forecast the production. Two well evaluation results are presented in this paper. Based on the results, completion parameters affected the short-term and long-term production, while the reservoir parameters controlled the long-term production. Long-term well performance was mainly controlled by the fracture half-length and fracture height, whereas other completion and reservoir parameters have an insignificant effect. Stimulation treatment design defines the initial well performance, while well placement decision defines well long-term performance. The findings of this study would help in better understanding the production performance of shale gas reservoirs, maximizing production by selecting effective completion parameters and considering the governing reservoir parameters. Moreover, it would help in accomplishing more effective stimulation treatments and define the potentiality of the basin.
Friction and wear behavior of carbon fiber reinforced lithium aluminosilicate composites sliding against GCr15 steel
Authors: Ma Haibao , Wu Xin , Xia Long , Huang Longnan , Xiong Li , Yang Hua , Zhong Bo , Zhang Tao , Yang Zhiwei , Gao Feng , Wen Guangwu 
Published: January 2020

AbstractCarbon fibers reinforced lithium aluminosilicate matrix composites (Cf/LAS) were prepared by slurry infiltration combined with a hot press procedure. The friction, wear behavior, and wear mechanisms of Cf/LAS composites under dry sliding conditions were investigated. The results show that the coefficient of friction (COF) initially increased with the increase in carbon fiber content, and reached the maximum value of 0.20 for the 33%Cf/LAS composite. The COF increased sharply with increasing sample temperature from RT to 300 °C. The COF remained stable in the temperature range of 300–500 °C. The two wear mechanisms of LAS glassceramics are fatigue wear and abrasive wear. The Cf/LAS composites demonstrate slight spalling and shallow scratches. These results show that carbon fibers improve the mechanical properties and wear resistance of Cf/LAS composites.