bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breast cancer in Thailand: policy and health system challenges to universal healthcare
Authors: Lakha Fatim , Suriyawongpaisul Paibul , Sangrajrang Suleeporn , Leerapan Borwornsom , Coker Richard 
Published: June 2020

AbstractThailand has successfully implemented Universal Health Coverage (UHC) and embedded the 2030 Agenda for Sustainable Development into its Thailand 4.0 policy. Breast cancer is a growing challenge in Thailand, as it is globally. It serves as a perfect medium through which to interrogate UHC and demonstrate areas of the health system which require further strengthening if UHC is to be sustainable in the longer term. We conducted a situation analysis and used a Systemic Rapid Assessment (SYSRA) framework to examine the challenges posed to UHC through the lens of breast cancer. We identified a number of challenges facing UHC including (1) continued political commitment; (2) the need for coordinated scale-up of strategic investments involving increased financing and fine-tuning of the allocation of resources according to health needs; (3) reducing inequities between health insurance schemes; (4) investing in innovation of technologies, and more critically, in technology transfer and capacity building; (5) increasing capacity, quality and confidence in the whole primary healthcare team but especially family medicine doctors. This would subsequently increase both efficiency and effectiveness of the patient pathway, as well as allow patients wherever possible to be treated close to their homes, work and family; (6) developing and connecting information systems to facilitate understanding of what is working, where needs are and track trends to monitor improvements in patient care. Our findings add to an existing body of evidence which suggest, in light of changing disease burden and increasing costs of care, a need for broader health system reforms to create a more enabling platform for integrated healthcare as opposed to addressing individual challenging elements one vertical system at a time. As low- and middle-income countries look to realize the 2015 Sustainable Development Goals and sustainable UHC this analysis may provide input for policy discussion at national, regional and community levels and have applicability beyond breast cancer services alone and beyond Thailand.
Inclusive innovation policy as social capital accumulation strategy
Authors: Klingler-Vidra Robyn , Liu Ye 
Published: June 2020

Abstract
Governments deploy policies that strive to increase the participation rates of under-represented demographic groups (according to gender, ethnicity, sexuality and disability status) in innovative activities. A growing thrust of these policies focuses on accumulating non-financial resources, particularly social capital, as the strategy for improving inclusion. Such policies include mentoring and networking schemes, role model campaigns, competitions and prizes. In contrast to the policies' growing prevalence, only a handful of studies have empirically analysed them, and fewer still offered analytical conceptualizations. In this article, we contribute by applying insights from the extant scholarship on social capital, innovation and entrepreneurship to conceptualize the policies in bonding and bridging social capital terms. We find that bonding strategies foster in-group connections, with the primary aim of encouraging under-represented groups to want to participate, thus focusing on increasing the supply of labour. Bridging strategies, in contrast, strive to link under-represented groups with finance and other centres of power, and to update societal preferences, in order to increase the demand for labour from under-represented groups. Our novel conceptualization emphasizes that policies should be studied according to their bonding or bridging social capital aims, as even the same policy instrument (i.e., mentorship scheme or campaign) can differ significantly in how it is employed.
Building Bridges from Genome to Phenome: Molecules, Methods and Models—An Introduction to the Symposium
Authors: Burnett Karen G , Durica David S , Mykles Donald L , Stillman Jonathon H 
Published: June 2020

Synopsis
How stable genotypes interact with their environment to generate phenotypic variation that can be acted upon by evolutionary and ecological forces is a central focus of research across many scientific disciplines represented within SICB. The Building Bridges Symposium brought together scientists using a variety of organisms, methods, and levels of biological organization to study the emergent properties of genomes. Workshops associated with the Symposium aimed to identify the leading edges and major barriers to research in this field, and to recommend future directions that might accelerate the pace of progress. The papers included in this Symposium volume draw attention to the strength of using comparative approaches in non-model organisms to study the many aspects of genotype–environment interaction that drive phenotype variation. These contributions and the concluding white paper also illustrate the need for novel conceptual frameworks that can bridge and accommodate data and conclusions from the broad range of study systems employed by comparative and integrative biologists to address genome-to-phenome questions.
Impact of delayed acceleration feedback on the classical car-following model
Authors: Kamath Gopal Krishna , Jagannathan Krishna , Raina Gaurav 
Published: June 2020

AbstractDelayed acceleration feedback (DAF) is known to have a positive impact on the stability properties of dynamical models in several applications. Motivated by this, we study the impact of DAF on the classical car-following model (CCFM). First, we show that DAF shrinks the locally stable region. We then show that the resulting model, similar to the CCFM, loses local stability via a Hopf bifurcation. However, DAF decreases the amplitude and increases the frequency of the resulting limit cycles. Additionally, we show that DAF is detrimental to the CCFM due to $(i)$ destruction of the non-oscillatory property of its solutions, $(ii)$ increased risk of string instability and $(iii)$ reduced resilience towards parametric uncertainty. Thus, we report a relevant application wherein DAF degrades the performance across several metrics of practical interest. Thus, our work motivates a systematic study of controllers that can guarantee performance enhancement. We complement our analytical results with stability charts and a bifurcation diagram.
Persistent low-level viraemia in antiretroviral treatment-experienced patients is not linked to viral resistance or inadequate drug concentrations
Authors: Palich R , Wirden M , Peytavin G , Lê M -P , Seang S , Abdi B , Schneider L , Tubiana R , Valantin M -A , Paccoud O , Soulié C , Calvez V , Katlama C , Marcelin A -G 
Published: June 2020

AbstractObjectivesTo assess genotypic sensitivity scores (GSSs), plasma antiretroviral concentrations (PACs) and immunovirological outcomes at Week 96 (W96) in patients with persistent low-level viraemia (LLV).MethodsOn 1 January 2017, we analysed data from patients on three-drug regimens with persistent LLV defined as at least two consecutive plasma viral loads (pVLs) between 21 and 200 copies/mL (including one pVL of ≥50 copies/mL), at the Pitié-Salpêtrière Hospital. Outcomes were: GSS, PACs and HIV-DNA load at study entry; and virological status and proportion of patients with resistance-associated mutations (RAMs) at W96.ResultsFifty-seven patients were included, with median age of 52.6 years (IQR 45.2–57.9), last CD4 count of 658 cells/mm3 (IQR 462–909) and total ART duration of 10.2 years (IQR 5.7–15.2). LLV duration was 14.0 months (IQR 5.5–22.3). GSS was 3 in 46/57 (81%) patients and PACs were adequate in 53/57 (93%) patients. Median total HIV-DNA was 2.65 log10 copies/106 cells (IQR 2.44–2.86). During follow-up, 26/57 (46%) had experienced ART modifications. At W96, 38/57 (67%) patients remained with LLV, 15/60 (26%) had achieved confirmed pVL of &lt;20 copies/mL and 4/57 (7%) had virological failure. The four virological failures were due to three ART interruptions and one incomplete adherence (selection of Y181C RAM). No factors (patient characteristics at study entry, GSS, PACs, total HIV-DNA load and ART modification) were associated with W96 viral outcome, except for time from HIV diagnosis and the LLV duration at study entry.ConclusionsA substantial number of patients harbouring LLV had no resistance to ART and adequate PACs. Two-thirds of these patients remained with this LLV status.
A Study to Evaluate the Need for Comminution in the Preparation of Food Materials for Testing of Listeria monocytogenes, Staphylococcus Species, and Generic Escherichia coli
Authors: Hanson Patricia , Mitchell Nicole , Caudle S Brian , Caulkins Lyndsey , Owens Cameron , Lewandowski Patty , Pickett Diane 
Published: June 2020

Abstract

Background
Comminution reduces the sampling error arising from distributional heterogeneity of the target contaminant/target analyte in the material, facilitating the selection of a more representative test portion. A laboratory sampling method incorporating comminution prior to selection of the test portion (Sampling Method B) was compared to current sampling methods that used no comminution step (Sampling Method A).

Objective
This required the development of an efficient process for comminution of food samples prior to removal of the test portion for the detection and isolation of Listeria monocytogenes and the enumeration of Staphylococcus species and Escherichia coli.

Method
From December 2016 to December 2017, 2742 tests were conducted on 778 unique food samples. For all food samples, a test portion (TPA) was first removed using Sampling Method A, and then the remainder of the material was comminuted and a second test portion (TPB) was removed using Sampling Method B and tested alongside the first portion.

Results
Across all food matrices and microbial targets, 17 additional targets were detected using only Sampling Method B, and positive detections of target analytes increased by 77% using Sampling Method B from the test portions taken using Sampling Method A.

Conclusion
Utilizing a sample preparation method that includes a comminution step resulted in an increased number of pathogen detections.

Highlights
The introduction of a comminution step in the preparation of food samples for detection of three common microbial contaminants resulted in an increase in the rate of detection of natural contaminates in a variety of ready to eat foods. An efficient aseptic process for commutation that can be adapted to a wide range of laboratory settings was identified.
Increasing the content of physically effective fiber in high-concentrate diets fed to beef heifers affects intake, sorting behavior, time spent ruminating, and rumen pH
Authors: Llonch Lourdes , Castillejos Lorena , Ferret Alfred 
Published: June 2020

AbstractAbstractThe importance of fiber particle size in ruminal health is well known, but there are fewer studies to assess the requirements of physically effective NDF (peNDF) in beef cattle than in dairy cattle. The objective of this study was to establish the optimal peNDF proportion in high-concentrate diets fed to beef cattle, to reduce the risk of subacute ruminal acidosis. The experimental design was a replicated Latin Square 4 × 4, with four periods of 21 d. Treatments consisted of four diets with different peNDF proportions: 6.4%, 10.4%, 13.6%, and 15.4%, offered ad libitum as total mixed ration, and containing 15% barley straw and 85% concentrate. Diets, which differed in proportions of straw &gt; 4 mm (considered peNDF) and straw &lt; 4 mm, were manually mixed with concentrate. This concentrate was the same for all diets. A ruminal bolus was orally administered to each heifer for pH measurement. Intake, water consumption, intake by particle size, feed sorting, feeding behavior, behavioral activities, and rumen pH were recorded. Chemical composition and particle sizes of diets offered were assessed in the last week of each period. Data were analyzed using the MIXED procedure of SAS. Orthogonal contrasts determined the linear and quadratic effects of increasing peNDF proportion. T-test procedure determined whether heifers carried out sorting behavior. Particles &gt;4 mm linearly increased (P = 0.001), and particles &lt;4 mm linearly decreased (P = 0.001) as peNDF increased. Water consumption and feeding behavior were unaffected by treatment. As peNDF increased, intakes of DM and NDF linearly decreased (P = 0.001), whereas peNDF intake increased (P = 0.001). Intake of particles &gt; 4 mm linearly increased, whereas intake of particles &lt; 4 mm linearly decreased (P = 0.001) as peNDF increased. Diet 6.4% performed sorting for particles &gt; 4 mm (P &lt; 0.01), and diets 13.6% and 15.4% against particles &gt; 4 mm (P &lt; 0.01). Diet 10.4% tended to sort against particles &gt; 4 mm (P &lt; 0.10). Time spent ruminating linearly increased (P = 0.001) as peNDF increased. Diets did not differ in mean and minimum rumen pH, but time under rumen pH thresholds (5.8, 5.7, 5.6, and 5.5) linearly decreased as peNDF increased (P &lt; 0.05). The results suggested that the diet that best met the requirements of not compromising intake, limiting sorting behavior, and promoting time spent ruminating to reduce the number of hours under rumen pH thresholds, was the 10.4% diet.
Impact of myoglobin oxygenation level on color stability of frozen beef steaks
Authors: Henriott Morgan L , Herrera Nicolas J , Ribeiro Felipe A , Hart Kellen B , Bland Nicolas A , Calkins Chris R 
Published: June 2020

Abstract
The emerging market of frozen meat emphasizes the need to better understand beef surface discoloration and the ideal parameters of freezing beef to retain an acceptable color. The objectives of this study were to determine the impacts of myoglobin oxygenation level prior to freezing and frozen storage duration on frozen beef color. USDA Choice strip loins (n = 36) were aged for 4 d or 20 d. Steaks were randomly assigned to a myoglobin oxygenation level [deoxygenated (DeOxy; immediately packaged after cutting), oxygenated (Oxy; oxygenated in air for 30 min), or highly oxygenated (HiOxy; packaged for 24 h in 80% O2)]. Steaks were then vacuum packaged in oxygen permeable or impermeable film and immediately frozen (−5 °C). Following either 0, 2, 4, or 6 mo of frozen storage, steaks were removed from the packaging and immediately analyzed for instrumental color (L*, a*, and b*), percent oxymyoglobin, metmyoglobin, and deoxymyoglobin, delta E, redness ratio, a*:b* ratio, hue angle, subjective discoloration, and lipid oxidation. The HiOxy steaks had greater oxygen penetration and the greatest a* values compared with DeOxy and Oxy steaks, regardless of packaging (P &lt; 0.0005). With 4 d of aging, HiOxy steaks had greater a* values than DeOxy and Oxy at all storage times (P = 0.0118). The HiOxy steaks aged for 20 d and frozen for 6 mo had significantly higher delta E values than all other myoglobin oxygenation levels and postmortem aging periods (P &lt; 0.0001). Redness and percent oxymyoglobin were highest for HiOxy steaks within each storage period (P &lt; 0.0002). The HiOxy steaks had the highest percent oxymyoglobin and DeOxy had the lowest percent oxymyoglobin within each aging and storage period (P &lt; 0.01). Conversely, DeOxy steaks had the highest percent metmyoglobin and HiOxy had the lowest percent metmyoglobin when packaged in impermeable film (P &lt; 0.0001). The HiOxy steaks from 20 d of aging had the highest discoloration compared with 4 d aging and more discoloration than all other myoglobin treatments at 6 mo of storage (P &lt; 0.0001). The HiOxy 20 d aged steaks exhibited the highest lipid oxidation values at 2, 4, and 6 mo (P = 0.0224) and HiOxy steaks exhibited a brighter and deeper cherry red color compared with the DeOxy steaks. The HiOxy steaks were greater in redness or similar when compared with Oxy steaks, but experienced more detrimental effects when frozen storage was extended.
A Case Study Evaluating the Efficacy of an Ad Hoc Hospital Collection Device for Fentanyl in Infant Oral Fluid
Authors: Gesseck Ashley M , Poklis Justin L , Wolf Carl E , Xu Jie , Bashir Aamir , Hendricks-Muñoz Karen D , Peace Michelle R 
Published: June 2020

Abstract
Neonatal drug exposure is currently assessed using meconium, urine, blood, hair, or umbilical cord tissue/blood. Due to the invasiveness, challenges, and limitations of collection, and/or analytical difficulties of these matrices, oral fluid may be a more desirable matrix in diagnosing opioid exposure and risk for opioid withdrawal in neonatal abstinence syndrome. Traditional oral fluid collection devices are not viable options as they are too large for neonates’ mouths and may contain chemicals on the collection pad. Unstimulated and stimulated infant oral fluid samples have been used for therapeutic drug monitoring as an alternative matrix to blood. The objective of this study was to assess the viability of a simple oral fluid collection system using a sterile foam-tipped swab rinsed in phosphate-buffered saline. Two infants were administered fentanyl for post-operative pain relief while hospitalized in the Neonatal Intensive Care Units at the Children’s Hospital of Richmond of Virginia Commonwealth University. Oral fluid samples were collected at 16 h, 2 days, and/or 7 days following the start of intravenous infusion of fentanyl. Samples were analyzed by ultra-high-pressure liquid chromatography–tandem mass spectrometry for fentanyl and norfentanyl after solid-phase extraction. In one of the three samples tested, fentanyl and norfentanyl were detected at concentrations of 28 and 78 ng/mL, respectively. Based on the infusion rate, the theoretical oral fluid fentanyl concentration at steady state was calculated to be 33 ng/mL.
Impact of reduced smoking rates on lung cancer screening programs in Japan
Authors: Hemmi Osamu , Nomura Yumiko , Konishi Hiroshi , Kakizoe Tadao , Inoue Manami 
Published: June 2020

Abstract

Background
In Japan, lung cancer screening by annual chest radiography has been performed for the past 30 years. However, changes in risk factor status may have influenced the efficiency of current organized lung cancer screening program. The purpose of this study was to clarify whether the reduced smoking rate in younger Japanese affects the efficiency and effectiveness of lung cancer screening.

Methods
We investigated chronological changes in epidemiological indicators, which support lung cancer screening programs offered by the Japan Cancer Society, such as gender- and age-specific numbers of participants and lung cancers detected by the screening by clinical stage, in relation to smoking rates from 1991 to 2016.

Results
Participant age at the time of screening and age at the time of cancer detection have both increased over time. The lung cancer detection rate (LCDR) in younger age cohorts tended to decrease from 1991 to 2016 in both genders, particularly men aged &lt;55 years. Age-adjusted LCDR significantly decreased from 1991 to 2016 in both genders. After 2001, ~45% of overall detected cases in men and 70% in women were found in stage I. Although trends differed between men and women, smoking rate decreased from 1991 to 2016 in most age cohorts in both genders.

Conclusions
These results suggest that organized lung cancer screening in Japan should be limited to higher-risk populations.
Evaluation of Filth Fly Species Composition and Abundance Using Two Monitoring Methods in Swine Confinement Housing
Authors: Machtinger Erika T , Burgess Edwin R 
Published: June 2020

AbstractConcentrated swine production can produce large amounts of accumulated waste that may serve as development sites for pest flies. Filth flies are not only a nuisance but can also interfere with animal growth and production and are capable of mechanically transmitting many pathogens to swine on confinement facilities. In addition to production and health concerns, high populations of filth flies developing on concentrated animal facilities may subject producers to nuisance litigation. While litigation against livestock producers associated with pest filth flies has become more frequent and high profile, information on the filth fly fauna in swine facilities in the United States is limited. In this study, filth fly species diversity and population fluctuations were monitored with spot and sticky cards in one sow facility and two finishing facilities in North Carolina. House flies Musca domestica L. (Diptera: Muscidae) were the dominant species followed by black dump flies Hydrotea (Ophyra) aenescens Weidemann (Diptera: Muscidae). A difference was seen in total spots on cards placed in more central barn locations than towards the outer walls in the sow facility but not the finishing facilities. Mean spots at only one of the finishing facilities exceeded the conventional control threshold of 100 spots/week, in May and June. Fly numbers decreased naturally in the following months, suggesting that standard control thresholds may not accurately inform filth fly control efforts in swine production. Due to their complementary nature, both spot and sticky cards placed in representative locations throughout barns are recommended. However, more swine-specific information is needed for optimizing monitoring methods.
Ventricular septal perforation followed by papillary muscle rupture with acute myocardial infarction: efficacy of venoarterial extracorporeal membrane oxygenation
Authors: Ushioda Ryohei , Fujii Atsuko , Shirakawa Makoto , Shirasaka Tomonori , Kikuchi Shinsuke , Kamiya Hiroyuki , Kanamori Taro 
Published: June 2020

Abstract
The occurrence of multiple mechanical complications after myocardial infarction in the same patient may be extremely rare, and the surgical strategy may be very complex because each mechanical complication can be extremely fatal. The case of a patient who underwent repair of a ventricular septal perforation by venoarterial extracorporeal membrane oxygenation (VA-ECMO), then mitral valve replacement and VA-ECMO for papillary muscle rupture 2 weeks after the ventricular septal perforation repair, is reported. Immediate preoperative stabilization with VA-ECMO may play a crucial role in treating multiple mechanical complications after myocardial infarction.
Indeterminate dendritic cell tumor in the pancreas
Authors: Sortino Rosita , Schmid Michael , El Baz Yassir , Loosen Antonia , Tarantino Ignazio , Steffen Thomas , Schmied Bruno M , Abbassi Fariba 
Published: June 2020

Abstract
Indeterminate dendritic cell tumor (IDCT) is an extremely rare hematologic neoplastic disorder with proliferation of indeterminate dendritic cells. In the vast majority of cases, IDCTs are restricted to the skin or lymph nodes. To our knowledge, we report the first case of IDCT in the pancreas. Due to the rarity of extracutaneous IDCT, guidelines or treatment recommendations addressing their management are missing. We performed a review of literature to compare our experience to the management of other extracutaneous IDCT. Histopathological examination confirms the diagnosis of IDCT in electron microscopy and/or immunohistochemistry. Specific features are the lack of Birbeck granules and the nonreaction to Langerin antibodies. Concerning the aftercare of extracutaneous IDCT, we recommend a dermatological examination to rule out an additional cutaneous manifestation as well as annual blood examinations due to the association between IDCT and hematologic malignancies.