bluuebunny/crossref_metadata_2025_split huggingface dataset:
The adoption and compliance to central line-associated bloodstream infection insertion and maintenance bundle programs in intensive care unit settings across Canada
Authors: Zhou Zhi Lin , Silva Anada , Cannon Kristine , Chow Blanda , Comeau Jeannette L. , Ellis Chelsey , Frenette Charles , Hadzic Amir , Happe Jennifer , Johnston Lynn , Katz Kevin C. , Khan Jamal , Langley Joanne M. , Lee Bonita E. , Lee Santina , Lefebvre Marie-Astrid , Lybeck Cassandra , McGeer Allison , Neitzel Andrew , Parsonage Jennifer , Patterson Connie , Quach Caroline , Science Michelle , Smith Stephanie W. , Thampi Nisha , Titoria Reena , Tomlinson Jen , Vayalumkal Joseph , Suh Kathryn N. , Srigley Jocelyn A. ,   the Canadian Nosocomial Infection Surveillance Program
Published: December 2024

AbstractEvidence-based insertion and maintenance bundles are effective in reducing the incidence of central line-associated bloodstream infections (CLABSI) in intensive care unit (ICU) settings. We studied the adoption and compliance of CLABSI prevention bundle programs and CLABSI rates in ICUs in a large network of acute care hospitals across Canada.
The Corruption of “Corruption”
Authors: Kovach Adam 
Published: December 2024

Abstract
Our contemporary understanding of political corruption draws from two different sources, a modern view that corruption occurs where officials follow improper procedures and a more ancient view of corruption as a systemic failure to live up to political ideals. The ability to shift between these views makes it easy for political partisans to locate corruption where it suits their political interests. Since accusations of corruption easily become challenges to the legitimacy of officeholders and institutions, there is danger in carelessness with the language of corruption. Awareness of these circumstances should lead us to be cautious with the language of corruption and to resist its slide toward becoming a mere means of political struggle.
Relationship between the ratio of increase in lean tissue to body weight gain and energy required to gain body weight in growing rats
Authors: Obikawa Kiyora , Kitaguchi Mizuki , Kondo Emi , Okamura Koji 
Published: December 2024

AbstractAlthough the energy stored in the lean tissue (LT) and adipose tissue (AT) is well known, the energy required to synthesise these tissues is obscure. Theoretically, the energy at the point at which ΔLT/Δ body weight (BW) reaches 100 % on a regression line, which indicates the relationship between ΔLT/ΔBW and the energy required for BW gain, is considered to be the energy expended to synthesise LT. Therefore, we investigated this relationship in rats. Rats were fed diets with different ratios of protein, fat and carbohydrates because their ΔLT/ΔBW values were expected to be different. Six-week-old male Sprague-Dawley rats had ad libitum access to normal (N, n 6), high-fat (HF, n 7) or high-protein (HP, n 8) diets for 4 weeks. The ΔLT/ΔBW was 0·77 in the N, 0·70 in the HF and 0·87 in the HP groups, respectively. The average energy required to gain BW was 8·8 kJ/g in the N group, 7·0 kJ/g in the HF group and 11·3 kJ/g in the HP group. We observed a positive correlation between ΔLT/ΔBW and energy required for BW gain. The regression line demonstrated that the energy expended to synthesise LT was 13·9 kJ/g and AT was −7·9 kJ/g. Therefore, combined with the energy stored in LT, the energy required to accumulate LT is approximately 19 kJ/g, whereas the energy to accumulate AT could not be elucidated.
Age-related differences regarding ageing and care service concerns and information preferences among LGBT, Sistergirl and Brotherboy people in Australia: a cross-sectional study
Authors: Brömdal Annette , Stanners Melinda N. , Mullens Amy B. , Beccaria Lisa , Debattista Joseph , Sargent Jennifer , Howard Chris , Matson Ann , Farmer Ged 
Published: December 2024

Abstract
Although many positive social changes have been achieved over the past 30 years, members of LGBT, Sistergirl and Brotherboy communities continue to encounter negative experiences with health and ageing service provision. In this article, 232 responses from a survey exploring ageing and care concerns and preferences among LGBT, Sistergirl and Brotherboy communities in Australia were analysed using chi square analysis. The largest proportion of participants were aged 55–64 years (26.4%, n = 61), with the majority residing in metropolitan regions (67.7%, n = 154). The three most frequently selected gender identities were cisgender woman (40.1%, n = 93), cisgender man (39.7%, n = 92) and non-binary (11.6%, n = 28). The three most frequently selected sexual orientations were gay (39.2%, n = 91), lesbian (32.0%, n = 77) and queer (17.7%, n = 41). While many concerns demonstrated no age-related differences, concerns regarding physical differences, respect and inclusion, finances and standard of care reflected higher levels of concern among younger participants compared with older participants. Preferences for receiving information reflected a desire for LGBT, Sistergirl and Brotherboy communities-specific resources for options for support from participants approaching retirement, that is, aged 55–64 (x2 (5, n = 178) = 11.08, p = 0.050); less desire for information provided through public health service services among participants aged 65+ (x2 (5, n = 178) = 15.58, p = 0.008); and variation in preferences regarding supports provided by LGBT, Sistergirl and Brotherboy communities. Results suggest that different generations of LGBT, Sistergirl and Brotherboy members may prefer to receive services and information in different ways. Further research is needed to understand how concerns, expectations and preferences are influenced across generations.
Diversity and abundance of vultures in relation to seasonality, age, and habitat types in Mole National Park, Ghana
Authors: Bornah Dorcas , Monney Kweku A. , Deikumah Justus P. 
Published: December 2024

Summary
In sub-Saharan Africa, and particularly within Ghana’s savanna ecosystem, scientific studies on the distribution patterns and habitat use of raptors, including vultures, are scarce. Despite global research on vulture abundance and habitat preferences, data from West Africa remain limited. This study examines the abundance of four vulture species, focusing on their seasonal activity, age distribution, and preference for three specific habitats, i.e. woodlands, riparian forests, and grasslands, in the southern part of Mole National Park (MNP), Ghana. We conducted a survey using 39 line transects during both dry and wet seasons to make an inventory of these species. Employing a generalised linear model, we assessed the influence of seasons, age, and habitat types on vulture abundance. Our survey recorded a total of 466 vultures, with Hooded Vulture Necrosyrtes monachus and White-backed Vulture Gyps africanus being the most frequently observed. Vulture numbers were notably higher in riparian and woodland areas than in grasslands, and adults were more prevalent than juveniles across all observed species. The study highlights the need for continuous monitoring and the protection of critical riparian habitats to aid in the conservation of these threatened species within the MNP.
Generation Mechanism of Oxygen Ion Cyclotron Harmonic Waves in the Inner Magnetosphere: Linear Instability Analysis Based on Observations
Authors: Wang Yan , Liu Kaijun , Cheng Kun , Mousavi Ameneh , Yao Fei , Wang Xinye , Wang Ruohan 
Published: December 2024

AbstractLinear kinetic instability analysis based on in situ observations for one typical oxygen ion cyclotron harmonic (OCH) wave event is performed to investigate the wave excitation mechanism. The observed partial‐shell velocity distribution of energetic O+s is fitted by the superposition of multiple ring‐beam distributions. The calculated linear growth rate shows that the observed OCH waves can be excited by energetic O+s with the partial‐shell velocity distribution, and the maximum growth rate occurs at the third harmonic, coinciding with the frequency associated with the maximum peak of the wave electric field power spectral density measured. In addition, it is found that cool heavy ions have a damping effect on the OCH waves near the corresponding heavy ion cyclotron frequency.
Ultra-rare monogenic disorders frequently detected among sex chromosome aneuploidy patients with atypical findings
Authors: Magee Kiana , McGonigle William , Pressman Rena , Thorson Willa , Barbouth Deborah , Borja Nicholas A. 
Published: December 2024

Abstract
Sex chromosome aneuploidies (SCA) such as Turner, Klinefelter, Jacobs, and Trisomy X syndromes are prevalent genetic disorders with well-established phenotypes. Challenges persist, however, in determining the need for further genetic evaluation in cases of affected individuals exhibiting atypical symptoms. The present study retrospectively examined 54 pediatric patients with an SCA diagnosis at a single institution between January 2015 and December 2023. Twelve patients (22.2%) exhibited a discordant phenotype, of which five were confirmed to have a distinct monogenic disorder, a diagnostic rate of 41.7%. The monogenic conditions identified included DNAH5-related primary ciliary dyskinesia, Burn-McKeown syndrome, Tatton-Brown-Rahman syndrome, SETD1B-related neurodevelopmental disorder, and SET-related disorder. The median age at SCA diagnosis was 3.5 months versus 7.0 years for the second genetic condition, indicating significant diagnostic delays. Our findings highlight the importance of comprehensive genetic evaluation in pediatric patients with SCA who exhibit atypical phenotypes.
Role of ZFHX4 in orofacial clefting based on human genetic data and zebrafish models
Authors: Ishorst Nina , Hölzel Selina , Greve Carola , Yilmaz Öznur , Lindenberg Tobias , Lambertz Jessica , Drichel Dmitriy , Zametica Berina , Mingardo Enrico , Kalanithy Jeshurun C. , Channab Khadija , Kibris Duygu , Henne Sabrina , Degenhardt Franziska , Siewert Anna , Dixon Michael , Kruse Teresa , Ongkosuwito Edwin , Girisha Katta M. , Pande Shruti , Nowak Stefanie , Hagelueken Gregor , Geyer Matthias , Carels Carine , van Rooij Iris A. L. M. , Ludwig Kerstin U. , Odermatt Benjamin , Mangold Elisabeth 
Published: December 2024

AbstractOrofacial clefting (OFC) is a frequent congenital anomaly and can occur either in the context of underlying syndromes or in isolation (nonsyndromic). The two common OFC phenotypes are cleft lip with/without cleft palate (CL/P) and cleft palate only (CPO). In this study, we searched for penetrant CL/P genes, by evaluating de novo copy number variants (CNV) from an exome sequencing dataset of 50 nonsyndromic patient-parent trios. We detected a heterozygous 86 kb de novo deletion affecting exons 4–11 of ZFHX4, a gene previously associated with OFC. Genetic and phenotypic data from our in-house and the AGORA cohort (710 and 229 individuals with nonsyndromic CL/P) together with literature and database reviews demonstrate that ZFHX4 variants can lead to both nonsyndromic and syndromic forms not only of CL/P but also CPO. Expression analysis in published single-cell RNA-sequencing data (mouse embryo, zebrafish larva) at relevant time-points support an important role of Zfhx4/zfhx4 in craniofacial development. To characterize the role of zfhx4 in zebrafish craniofacial development, we knocked out/down the zebrafish orthologue. Cartilage staining of the zfhx4 CRISPR F0 knockout and morpholino knockdown at 4 days post-fertilization showed an underdeveloped and abnormally shaped ethmoid plate and cartilaginous jaw (resembling micrognathia). While there is evidence for the dominant inheritance of ZFHX4 variants in OFC, we here present a patient with a possible recessive inheritance. In conclusion, ZFHX4 has a highly heterogeneous phenotypic spectrum and variable mode of inheritance. Our data highlight that ZFHX4 should be considered in genetic testing in patients with nonsyndromic clefting.
Titanate–polyurethane–chitosan ternary nanocomposite as an efficient coating for steel against corrosion
Authors: Abdellatif Ahmed S. , Shahien Mohammed , El-Saeed Ashraf M. , Zaki Ayman H. 
Published: December 2024

AbstractIn this study, a titanate–polyurethane–chitosan ternary nanocomposite was prepared by physical mixing. Sodium titanate nanotubes (Na-TNTs) were prepared by the hydrothermal method, and chitosan was extracted from shrimp shell. Na-TNTs were mixed with polyurethane (PU) of different ratios by weight, and chitosan was added after optimization. All of the nanocomposite samples were characterized by field-emission scanning electron microscopy (FESEM), and the mechanical properties were investigated by abrasion, adhesion pull-off, impact resistance, and T-bending tests. The anticorrosion ability was tested by the salt spray method. The obtained results revealed that the binary composite of PU and 1.5% Na-TNTs exhibited remarkable anticorrosion activity among all the binary composites where the disbonded area 5% compared to blank PU 19% and adhesion 5.1 MPa compared to blank 3.5 MPa, while the ternary composite containing 4% chitosan exhibited the best anticorrosion activity where the disbonded area 2% and also exhibit better adhesion 7.9 MPa.
Long-term effects of adding biochar to soils on organic matter content, persistent carbon storage, and moisture content in Karagwe, Tanzania
Authors: Ernest Baraka , Yanda Pius Z. , Hansson Anders , Fridahl Mathias 
Published: December 2024

AbstractSoils require the application of biochar to improve degradation. The objective of this study was to evaluate the long-term effects of a field experiment on soil organic matter (SOM), soil organic carbon (SOC), and soil moisture content in Karagwe, Tanzania. Seven years ago, a field experiment was conducted using a Latin rectangle design with four replications. The treatments included carbonization and sanitation (CaSa) and carbonization and standard compost (CaSt), which were compared to control Andosols (CoA). A total of 96 soil samples were collected to determine SOM, SOC, and soil moisture content. The data were analyzed using one-way analysis of variance. The results showed that soil samples from the CaSa-treated soil had an increase in SOM content of 17.3%, an increase in stored SOC content of 10.0%, and an increase in soil moisture content of 6.3%. Compared with those in CoA, the CaSt-treated soil showed increases in SOM, SOC, and soil moisture of 14.4%, 8.4%, and 4.0%, respectively. Therefore, all treatments improved soil properties, with CaSa proving more effective in enhancing SOM, SOC, and soil moisture content compared to CaSt and CoA. In conclusion, CaSa is recommended for its sustainable ability to enhance Karagwean soil over time.
Deceleration capacity derived from a five-minute electrocardiogram predicts mortality in the general population
Authors: Steger Alexander , Barthel Petra , Müller Alexander , Rückert-Eheberg Ina-Maria , Linkohr Birgit , Allescher Julia , Maier Melanie , Hapfelmeier Alexander , Martens Eimo , Heidegger Helene Hildegard , Müller Arne Michael , Rizas Konstantinos D. , Kääb Stefan , Sinner Moritz F. , Sinnecker Daniel , Laugwitz Karl-Ludwig , Peters Annette , Schmidt Georg 
Published: December 2024

AbstractIn contemporary healthcare, effective risk stratification in the general population is vital amidst rising chronic disease rates and an ageing demographic. Deceleration Capacity of the heart rate (DC), derived from 24-hour Holter electrocardiograms, holds promise in risk stratification for cardiac patients. However, the potential of short-term electrocardiograms of five minutes duration for population screening has not been fully explored. Our study aims to investigate the utility of Deceleration Capacity derived from short-term electrocardiograms as a scalable, fully-automated screening tool for predicting long-term mortality risk in the general population. Within a cohort of a representative population-based survey in Germany (KORA-KMC-study), 823 participants with sinus rhythm aged 27 to 76 years at enrollment (females 47.4%) were followed for a median of 13.4 years (IQR 13.1–13.6). All-cause mortality was defined as the primary endpoint and observed in 159 participants. Deceleration Capacity was calculated from 5-minute 12-lead electrocardiograms by a fully automated approach. Participants were divided into three predefined risk categories: DCcategory0 – low-risk (> 4.5ms); DCcategory1 – intermediate-risk (2.5-4.5ms); and DCcategory2 – high-risk (≤ 2.5ms). More than two-thirds of the participants (n = 564, 68.5%) fell into DCcategory0, about one-fifth (n = 168, 20.4%) into DCcategory1, and about one-tenth (n = 91, 11.1%) into DCcategory2. Estimated 13-years mortality in the risk groups was 16.7%, 23.5%, and 49.1%, respectively (p < 0.001). Adjusting for age, life-style-related risk factors, and comorbidities, increased mortality risk was observed for DCcategory2 (HR 2.34, 95%-CI 1.56–3.50). Deceleration Capacity, derived automatically from brief 5-minute electrocardiogram recordings, emerges as a robust, feasible, and independent predictor of long-term mortality risk in the general population.
Optimising the paradigms of human AI collaborative clinical coding
Authors: Gao Yue , Chen Yuepeng , Wang Minghao , Wu Jinge , Kim Yunsoo , Zhou Kaiyin , Li Miao , Liu Xien , Fu Xiangling , Wu Ji , Wu Honghan 
Published: December 2024

AbstractAutomated clinical coding (ACC) has emerged as a promising alternative to manual coding. This study proposes a novel human-in-the-loop (HITL) framework, CliniCoCo. Using deep learning capacities, CliniCoCo focuses on how such ACC systems and human coders can work effectively and efficiently together in real-world settings. Specifically, it implements a series of collaborative strategies at annotation, training and user interaction stages. Extensive experiments are conducted using real-world EMR datasets from Chinese hospitals. With automatically optimised annotation workloads, the model can achieve F1 scores around 0.80–0.84. For an EMR with 30% mistaken codes, CliniCoCo can suggest halving the annotations from 3000 admissions with an ignorable 0.01 F1 decrease. In human evaluations, compared to manual coding, CliniCoCo reduces coding time by 40% on average and significantly improves the correction rates on EMR mistakes (e.g., three times better on missing codes). Senior professional coders’ performances can be boosted to more than 0.93 F1 score from 0.72.
Functional anatomy and topographical organization of the frontotemporal arcuate fasciculus
Authors: Basile Gianpaolo Antonio , Nozais Victor , Quartarone Angelo , Giustiniani Andreina , Ielo Augusto , Cerasa Antonio , Milardi Demetrio , Abdallah Majd , Thiebaut de Schotten Michel , Forkel Stephanie J. , Cacciola Alberto 
Published: December 2024

AbstractTraditionally, the frontotemporal arcuate fasciculus (AF) is viewed as a single entity in anatomo-clinical models. However, it is unclear if distinct cortical origin and termination patterns within this bundle correspond to specific language functions. We use track-weighted dynamic functional connectivity, a hybrid imaging technique, to study the AF structure and function in two distinct datasets of healthy subjects. Here we show that the AF can be subdivided based on dynamic changes in functional connectivity at the streamline endpoints. An unsupervised parcellation algorithm reveals spatially segregated subunits, which are then functionally quantified through meta-analysis. This approach identifies three distinct clusters within the AF - ventral, middle, and dorsal frontotemporal AF - each linked to different frontal and temporal termination regions and likely involved in various language production and comprehension aspects. Our findings may have relevant implications for the understanding of the functional anatomy of the AF as well as its contribution to linguistic and non-linguistic functions.
Auditory brainstem responses as a biomarker for cognition
Authors: Hamza Yasmeen , Yang Ye , Vu Janie , Abdelmalek Antoinette , Malekifar Mobina , Barnes Carol A. , Zeng Fan-Gang 
Published: December 2024

AbstractA non-invasive, accessible and effective biomarker is critical to the diagnosis, monitoring and treatment of age-related cognitive decline. Recent work has suggested a strong association between auditory brainstem responses (ABR) and cognitive function in aging macaques. Here we show in 118 human participants (66 females; age range=18-92 years; hearing loss = -5 to 70 dB HL) that cognition is associated with both age and hearing level, but this triad relationship is mainly driven by the age factor. After adjusting for age, cognition is still significantly associated with both the ABR wave V amplitude (B, 0.110, 95% CI, 0.018– 0.202; p = 0.020) and latency (B, -0.101, 95% CI, -0.186– -0.016; p = 0.021). Importantly, this age-adjusted ABR-cognition association is primarily driven by older individuals and language-dependent cognitive functions. We also perform the area under the curve (AUC) of the receiver-operating-characteristic analysis and find that the ABR wave V amplitude is best for detecting good cognitive performers (AUC = 0.96) whereas the wave V latency is best for detecting poor ones (AUC = 0.86). The present result not only confirms the previous animal work in humans but also shows the clinical potential of using auditory brainstem responses to improve diagnosis and treatment of age-related cognitive decline.
Discovering covalent cyclic peptide inhibitors of peptidyl arginine deiminase 4 (PADI4) using mRNA-display with a genetically encoded electrophilic warhead
Authors: Mathiesen Isabel R. , Calder Ewen D. D. , Kunzelmann Simone , Walport Louise J. 
Published: December 2024

AbstractCovalent drugs can achieve high potency with long dosing intervals. However, concerns remain about side-effects associated with off-target reactivity. Combining macrocyclic peptides with covalent warheads provides a solution to minimise off-target reactivity: the peptide enables highly specific target binding, positioning a weakly reactive warhead proximal to a suitable residue in the target. Here we demonstrate the direct discovery of covalent cyclic peptides using encoded libraries containing a weakly electrophilic cysteine-reactive fluoroamidine warhead. We combine direct incorporation of the warhead into peptide libraries using the flexible in vitro translation system with a peptide selection approach that identifies only covalent target binders. Using this approach, we identify potent and selective covalent inhibitors of the peptidyl arginine deiminase, PADI4 or PAD4, that react exclusively at the active site cysteine. We envisage this approach will enable covalent peptide inhibitor discovery for a range of related enzymes and expansion to alternative warheads in the future.