bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-referral of Chinese patients with advanced chronic kidney disease and treatment decision-making: A qualitative study
Authors: Gao Ya jing , Shan Yan , Zhou Yue , Jiang Ting ting , Li Xue , Jiang Xinxin , Cai Li , Xu Sa , Chang Tian ying , Wang Hong 
Published: August 2020

Abstract
Background: Chinese patients with advanced chronic kidney disease, especially rural patients possibly occur self-referral behavior and then treatment decisions followed. It is unclear the relationship between self-referral and treatment decision-making. Thus, the aim of this study was to explore HCPs and patient with advanced CKD perceptions of self-referral and treatment decision making. Methods: We conducted semi-structured interviews with 22 patients with advanced kidney disease and 8 health care professionals. Interviews were conducted and analyzed thematically until reaching thematic saturation. Results: We identified three themes reflected: 1) self-referral decision making (self-referral motive, barrier to self-referral, seeking for self-referral information); 2) the views and experience of self-referral care (facilitating shared decision making, imposing psychological pressure, feeling about self-referral communication, challenge to staff-patient relationship); 3) treatment decision making (decisional awareness and roles, cost-benefit trade-off and redicision). Conclusions: Our study identified that organizational and demographic factors, self-referral motives worked together at the self-referral decision-making and treatment decision-making when advanced CKD patients facing with healthcare facilities and treatment options. Those findings suggest stakeholders should accelerate the popularization of peritoneal dialysis technology and establish the CKD screening and management systems. For self-referral patients with advanced CKD, our results suggest specialized dialysis transition care to improve quality of communication and soothe patients’ negative emotion.
Effect of Dietary Curcumin on the Growth Performance, Serum Antioxidation and Meat Quality of Ducks (Anas Platyrhynchos)
Authors: Jin Sanjun , Yang Hao , Liu Fangju , Diao Xinping , Pang Qian , Liu Ruiqi , Wang Min , Wang Yingjie , Liu Mengru , Zhou Xin , Shan Anshan , Feng Xingjun 
Published: August 2020

Abstract
Background: With increasing of duck meat among consumers, the demand for growth performance and the meat quality health of ducks in increasing. Dietary curcumin altered the growth performance and meat quality. However, study on the effect of dietary curcumin on the growth performance, serum antioxidation and meat quality of ducks. This study invested effects of dietary curcumin given to ducks on the growth performance, antioxidation capacity in plasma, meat quality, lipid oxidation and the concentration of volatile compounds in duck breast muscle. A total of 600 healthy ducks with similar body weight were randomly allotted into 4 groups with 10 replicates per group and 15 ducks per replicate. Ducks were fed experimental diets which the curcumin supplemental levels were 0, 300, 400 and 500 mg curcumin/kg basic fed, respectively. The experiment lasted for 10 weeks. Results: Results showed that dietary supplementation of curcumin at levels 300, 400 and 500 mg/kg dietary (P < 0.05) improved the average final body weight. The ducks fed the basal diet without curcumin supplementation had the lowest FI (P > 0.05) and highest FCR (P > 0.05) among all ducks. Feeding ducks on diets supplemented with curcumin at each level significantly increased (P < 0.05) plasma activity of T-SOD and GSH-Px, and significantly reduced plasma MDA concentration compared to the control group. The dietary curcumin significantly increased the growth performance and the antioxidation capacity in plasma of ducks. Dietary curcumin improved the meat quality of ducks by significantly increasing pH45, pH24 (P < 0.05) and color of duck meat (P < 0.05), and significantly decreasing cooking loss (P < 0.05), shear force (P < 0.05), and the lipid oxidation of duck meat. 56 volatile compounds were identified and quantified. Interestingly, cantharidin among volatile compounds was firstly found in duck muscle, and only existed in the group of 500 mg curcumin/kg diet. Conclusions: In conclusion, the supplementation of duck diets with curcumin at 300, 400, and 500 mg/kg diet improved growth performance, antioxidant status and meat quality of ducks. The cantharidin was firstly found in duck breast muscle when the dietary curcumin inclusion of 500 mg/kg.
Comparison Between Less Invasive Surfactant Administration (LISA) and Intubation-Surfactant-Extubation (InSurE) in Preterm Infants with Respiratory Distress Syndrome: A Retrospective Study
Authors: Yang Sungmin , Kim Yong Hyuk , Lee Byoung Kook 
Published: August 2020

Abstract
Background: Bronchopulmonary dysplasia (BPD) is an important morbidity caused by neonatal lung injury due to mechanical ventilator use. Respiratory distress syndrome (RDS) is leading cause of mechanical ventilation in preterm infants. Surfactant was administrated through the endotracheal tube for management of RDS, which compels invasive mechanical ventilation. Recently, Intubation-SURfactant administration-Extubation (INSURE) and Less-invasive surfactant administration (LISA) have been introduced to avoid invasive mechanical ventilation. This study aimed to compare the effectiveness of LISA and INSURE.Methods: This single-center, retrospective study enrolled 47 newborns admitted to the neonatal intensive care unit (NICU) of the Wonju Severance Christian’s Hospital between January 1, 2017 and August 31, 2019, above a gestational age of 25 weeks, and required surfactant. The patient were divided into the LISA group and the INSURE group, and compared capillary gas analysis, oxygen saturation index (OSI), and morbidities.Results: The LISA group and the INSURE group included 34 and 13 newborns respectively. Demographic feature and OSI showed no significant differences between two groups. In the LISA group, pCO2 decreased over 1 hour(57.49±9.43mmHg), 2 hours(53.07±9.25mmHg, p=0.04) and 6 hours (46.50±8.53mmHg, p=0.01). pCO2 of the INSURE group decreased steeper within 2 hours (49.55±8.96mmHg to 39.56±6.20mmHg) in the INSURE group, however, the trend was not significant (p = 0.06). There were no significant differences in morbidities. Discussion: LISA and INSURE showed no significant differences in OSI and morbidities. Although LISA decreases pCO2 more slowly than INSURE, the difference is not statistical significant. LISA and INSURE are equally effective modalities for surfactant administration.
Association of Triglyceride-glucose Index and the Risk of Incident Diabetes: a Secondary Analysis Based on a Chinese Cohort Study
Authors: Li Xiaoli , Li Guilong , Cheng Tiantian , Liu Jing , Song Guangyao , Ma Huijuan 
Published: August 2020

Abstract
BackgroundTriglyceride-glucose index (TyG index) has been regarded as a reliable alternative marker of insulin resistance. However, study on the relationship between TyG index and incident diabetes remains limited. This study aimed to investigate the association between TyG index and incident diabetes in a large cohort of Chinese population.MethodsThe present study was a retrospective cohort study using healthy screening programme data in China. A total of 201,298 subjects free of baseline diabetes were included who received a health check with all medical records from 2010 to 2016. TyG index was calculated as Ln[fasting triglyceride level (mg/dl) x fasting plasma glucose (mg/dl)/2]. Diagnosis of diabetes was based on fasting plasma glucose ≥ 7.00 mmol/L and/or self-reported diabetes. Cox proportion-hazard model was used to assess the relationship between TyG index at baseline and the risk of incident diabetes. It should be noted that the data was uploaded to the DATADRYAD website, and we only used this data for secondary analysis.ResultsDuring a mean follow-up of 3.12 years of 201,298 individuals aged ≥ 20 years old, 3389 subjects developed diabetes. After adjusting for age, sex, body mass index, systolic blood pressure, diastolic blood pressure, total cholesterol, low density lipoprotein cholesterol, alanine aminotransferase, aspartate aminotransferase, serum creatinine, smoking, drinking and family history of diabetes, multivariate cox hazards regression analysis indicated that TyG index was positive correlation with the risk of developing diabetes in Chinese population (HR, 3.34; 95% CI, 3.11 to 3.60). The risk of incident diabetes increased with increasing TyG index. Subjects with TyG index in the fourth quartile were 6.26 times more likely to develop diabetes than the lowest quartile (P trend < 0.001). Subgroup analysis showed the stronger association was observed in the population with age < 40, BMI (≥ 18.5, < 24 kg/m2), SBP < 140 mmHg or females (all P for interaction < 0.0001).Conclusions TyG index was independently correlated with the increased risk of diabetes in Chinese adults, suggesting that TyG index may be a useful marker for identifying individuals at high risk of developing diabetes.
Empowering Researchers and Knowledge-Producing Organizations for Evidence-Informed Health Policy Making: Interventions in the Iranian Health System
Authors: Doshmangir leila , Mostafavi Hakimeh , Majdzadeh Reza 
Published: August 2020

Abstract
Background: Providing appropriate information to policymakers by strengthening evidence-based capacity is a key factor in the development of evidence-based policy making (EIPM). This study aims to examine the necessary interventions in the Iranian health system for empowering researchers and knowledge-producing organizations to strengthen EIPM.Methods: This qualitative study was conducted using interviews and document review. The views and experiences of enterviewees were extracted through semi-structured interviews. Purposive sampling was used and continued until data saturation. Thematic framework analysis and MAXQDA 12 software were used for data analysis.Results: Necessary interventions for empowering researchers and knowledge-producing organizations were categorized into health system interventions, community-based interventions, organization interventions, and individual interventions.Conclusion: Incompatibility of health policy decisions with scientific evidence derived from research highlights the importance of creating a common language among health policymakers and researchers. In this regard, developing scientific and practical interventions, educating health researchers on knowledge translation, and using mechanisms and networks for effective interaction will be constructive.
German Translation, Cultural Adaption and Validation of the Unidimensional Self-efficacy Scale for Multiple Sclerosis Using Rasch Analysis
Authors: Seebacher Barbara , Mills Roger , Reindl Markus , Zamarian Laura , Kircher Simone , Brenneis Christian , Ehling Rainer , Deisenhammer Florian 
Published: August 2020

Abstract
Background

Self-efficacy refers to people’s beliefs in their ability to perform relevant activities to achieve personal goals. In people with multiple sclerosis (PwMS), self-efficacy has been shown to significantly impact health-related behaviour. So far, a validated German language self-efficacy scale for PwMS is missing. Therefore, the aims his study were to translate the Unidimensional Self-Efficacy Scale for Multiple Sclerosis (USE-MS) into German, establish face and content validity and cultural adaption of the German version for PwMS in Austria. Further aims were to validate the German USE-MS (USE-MS-G) in PwMS using Rasch analysis.
Methods

Formal permission to translate and validate the USE-MS was received from the scale developers. Following guidelines for translation and validation of questionnaires and applying Bandura’s concept of self-efficacy, the USE-MS was forward-backward translated, and content and face validity established. Cultural adaption for Austria was performed using cognitive interviews of 30 PwMS. The validation by Rasch analysis, of the final USE-MS-G involved 309 PwMS with minimal to severe disability using scales for resilience, general self-efficacy, anxiety and depression, MS fatigue and health-related quality of life. Re-test was conducted within 14–21 days after the initial test. Data were also pooled with an historic English dataset.
Results

Using a bi-factor solution, excellent external and construct validity, internal consistency, person separation reliability, test-retest reliability and fit to the Rasch model was demonstrated. The USE-MS-G was shown to be unidimensional, well-targeted and free from differential item functioning. Pooling of the English and German datasets confirmed equivalence of the two language versions.
Conclusion

The USE-MS-G is a robust, valid and reliable scale to assess self-efficacy in PwMS. Rasch model fit given, an interval scale transformation table is available for clinical settings and research.
Trial registration:

ISRCTN Registry; ISRCTN14843579; prospectively registered on 02. 01. 2019; http://www.isrctn.com/ISRCTN14843579
Different recovery from respiratory failure and functional changes after lung cancer surgery depending on the extent of resection, the influence of COPD
Authors: Pezzuto Aldo , Marinucci Beatrice Trabalza , Pagliuca Alessandra , Salvucci Claudia , Guerrieri Giulio , D’Ascanio Michela , Ricci Alberto , Ciccozzi Massimo , Rendina Erino Angelo 
Published: August 2020

Abstract
BACKGROUNDLung cancer is recognized to be the main cause of cancer death worldwide and it is closely associated with cigarette smoking and chronic obstructive pulmonary disease (COPD). Only about 15% of patients affected by lung cancer are suitable for surgery and the clinical postoperative outcomes are variable.We aim to investigate the variables that affect post-surgery complications .METHODS A sample of 65 COPD patients who underwent surgery for lung cancer was retrospectively studied about respiratory function and arterial gasanalysis .Data were collected before and after surgery.A subgroups comparative analysis was performed between group who underwent lobectomy vs group who underwent sub-lobar resection represented by either wedge or segmentectomy.RESULTSThe overall data were: mean age 71.5, hospitalization time 7.8 days, pack-year 34, body mass index (BMI) 25.4, chronic obstructive pulmonary disease(COPD) assessment test (CAT) mean value was 16.5, forced expiratory one second volume (FEV1) at baseline 1.6 l corresponding to 73.6% of predicted.The mean age was 71.5, males/females rate 35/30The prevalent stage was IA and prevalent histotype was adenocarcinoma.Among the variables affecting the long lasting oxygen therapy (24 hours a day) only the type of surgery along with presence of COPD showed a significant impact.The relationship between the type of surgery and the lasting of oxygen therapy after surgery showed that lobectomy was 90% more likely to be associated with long lasting oxygen therapy than sub-lobar resection (p<0.0005). Abnormal CAT questionnaire > 10 was also associated with greater risk of long lasting daily oxygen therapy(p<0.04).The subgroups were comparable for age and pack-year , and for PaO2, FEV 1 and FVC at baseline. A significant difference was observed in terms of hospitalization time (p<0.03) that was longer in group of lobectomy and PaO2 post-surgery (p<0.04).Changes between pre and post surgery about the main functional parameters FEV1 and FVC revealed a greater reduction of the above in the group who underwent lobectomy (p<0.001) compared with group treated with sub-lobar resection.The recovery from lung failure was higher in group with sublobar resection at 3 month check.CONCLUSIONSAll patients affected by lung cancer who undergo surgery report lung failure of different intensity depending on the type of surgery.COPD itself could influence the outcome, too. A greater negative variations of functional parameters after surgery is found in group who undergo lobectomy.
Impact of biochar on the metabolic networks of a PHE-degrading microbial community and its influencing mechanism on soil biogeochemical cycles
Authors: Li Dapeng , Li Xianyue , Song Qiuying , Wang Qiquan , Jiang Xinxin , Tang Long , Gao Yang , Zhao Xinyue , Zang Hailian , Zhao Wei , Li Chunyan , Hou Ning 
Published: August 2020

Abstract
Background: Straw pyrolysis into biochar are beneficial for resource recovery and soil improvement. However, little is known about how biochar influences polycyclic aromatic hydrocarbons (PAHs) metabolic pathways and biogeochemical cycles in PAH-contaminated agricultural soil. Here we assessed the influence of biochar and bacterial inoculant on the soil physicochemical properties, the microorganisms involved in the metabolism of PAH and C, N, P and S cycling.Results: The addition of biochar and bacterial inoculant improved soil fertility and crop nutrition. The community metabolism of phenanthrene was revealed by modeling a gene network based on shotgun metagenomes. Biochar addition in soil promoted the abundance of various phenanthrene-degrading microorganisms involved in multiple steps of phenanthrene catabolism, thereby promoting phenanthrene degradation. Meanwhile, biochar addition increased nitrate reduction and degradation of relatively easily decomposable organic carbon, including cellulose, but it also inhibited lignin and chitin degradation and C and N fixation, while the addition of bacterial inoculant partially mitigated biochar’s inhibitory effects in element cycle and inhibited N2O emission, which alleviated the greenhouse effect.Conclusions: When bioremediating PAH-contaminated soil, recommendation is to use biochar combined with functional microorganism. This work contributes to expand the current knowledge of the treatment of contaminated soil and provide some empirical evidence for the treatment of contaminated soil by biochar and bacterial inoculant.
Explore the mechanism of Shengma-Gegen drug pair on hepatitis B virus based on network pharmacology
Authors: Zhang Guozhe , Chen Chunmiao , Qin Yiyu , Ji Jianwei 
Published: August 2020

Abstract
Background

Sheng-Ma-Ge-Gen-Tang (SMGGT; 升麻葛根汤) is a famous prescription of traditional Chinese medicine used against measles of children for many hundreds of years. And its anti-hepatitis B virus (HBV) activity has been justified in clinical, however, the function substances and the mechanisms have not been studied yet.
Methods

The latent active compounds of Cimicifugae Rhizoma (Shengma)-Radix Puerariae (Gegen) drug pair were searched, and excavated their related targets. Then seek the targets of HBV through three network databases. The drug-disease targets of protein-protein interaction (PPI) data was carried out. The drug-disease targets were enriched by gene ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. Subsequently, anti-HepG2.2.15 cytotoxicity and anti-HBV experiments were performed on the aqueous and ethanol extracts of Shengma-Gegen in vitro to test and verify their anti-HBV activities.
Results

GO enrichment indicated biological processes (cellular response to lipid, cellular response to organic cyclic compound, etc.), cellular components (vesicle lumen, cytoplasmic vesicle lumen, etc.) and molecular function (kinase binding, steroid binding, etc.). Many cancer-related pathways were enriched in KEGG pathway analysis. Also got some virus and bacteria diseases. A KEGG-targets network showed that RAF1, CCND1, BCL2, and EGFR might be the core targets. Cytotoxicity of Shengma and Gegen to HepG2.2.15 are in proportion to their concentrations. Shengma and Gegen aqueous and ethanol extracts exhibited a curtain extant anti-HBV-DNA activity.
Conclusions

Shengma-Gegen showed not only anti-HBV activity but also anti-tumor and anti-viral activities, which need to be tested in the future.
Prevalence and Determinants of Diabetic Peripheral Neuropathy/Foot Syndrome in a rural population of North India
Authors: Bashar MD Abu 
Published: August 2020

Abstract
Background Diabetic peripheral neuropathy (DPN), a common and troublesome complication in patients with type 2 diabetes mellitus (T2DM), contributes to a higher risk of diabetic foot ulcer and lower limb amputation. These situations can negatively impact the quality of life of affected individuals.Objectives The study aimed to assess prevalence of DPN in patients of type 2 DM from rural North India and associated risk factors. Methods A facility based cross sectional study was carried out among type 2 diabetic patients attending NCD clinic of a secondary care hospital in rural North India. A questionnaire which included socio-demographic details, clinical and laboratory parameters, and the Michigan Neuropathy Screening Instrument (MNSI) for detecting peripheral neuropathy, was administered to 100 consecutive patients. Statistical Package for Social Sciences (SPSS) version 25.0 was used for entering and analyzing data. Bivariate analysis was performed for determining the factors significantly associated with presence of DPN. Results The prevalence of DPN was 42.0%. Male gender, advancing age(≥60 years), longer duration of diabetes (>10 years ), smoking, physical inactivity, obesity, uncontrolled blood pressure, poor A glycaemic control and altered lipid profile were found to be significantly associated with the presence of DPN. Conclusion Prevalence of DPN among type 2 diabetics from rural north India is alarmingly high. There is need of essential screening of all diabetic patients by their primary care provider for early detection of DPN particularly in rural India.
Proteoglycan remodeling is accelerated in women with angina pectoris and diffuse myocardial fibrosis: the iPOWER Study
Authors: Mygind Naja Dam , Nielsen Signe Holm , Michelsen Marie Mide , Pena Adam , Bechsgaard Daria Frestad , Suhrs Elena , Bove Kira Bang , Genovese Federica , Nielsen Henning Bay , Karsdal Morten , Vejlstrup Niels , Prescott Eva , Kastrup Jens 
Published: August 2020

Abstract
Background

Women with angina and no obstructive coronary artery disease have an unfavourable prognosis, possibly due to coronary microvascular disease and diffuse myocardial fibrosis. In diffuse myocardial fibrosis myocardial extracellular matrix proteins, including the proteoglycans biglycan and versican are actively remodeled by matrix metalloproteinase. We investigated MMP-mediated degradation of biglycan and versican in women with possible DMF assessed by cardiac magnetic resonance T1 mapping.
Methods

Seventy-one women with angina pectoris and a coronary angiogram with no significant obstructive coronary artery disease (< 50% stenosis) were included. Asymptomatic age-matched women served as controls (n = 32). Matrix metalloproteinase 12 generated neo-epitope fragment of versican (VCANM) and MMP-9 generated fragment of biglycan (BGM) were measured in serum by specific competitive enzyme-linked immunosorbent assays (ELISAs). T1 mapping was performed by cardiac magnetic resonance with gadolinium (0.1 mmol/kg) using a look-locker pulse sequencing measuring T1 and extracellular volume.
Results

Both BGM and VCANM levels were higher in symptomatic women compared with controls; 31.4 ng/mL vs. 16.4 ng/mL (p < 0.001) and 2.1 ng/mL vs. 1.8 ng/mL (p < 0.001), respectively. Both BGM and VCANM were moderately correlated to global extracellular volume (r2 = 0.38, p < 0.001 and r2 = 0.26, p = 0.015 respectively).
Conclusion

Turnover of BGM and VCANM was increased in symptomatic women compared to asymptomatic women and associated to extracellular volume, supporting a link between angina with no obstructive coronary artery disease and fibrotic cardiac remodeling. The examined biomarkers may prove to be suitable for monitoring active extracellular matrix remodeling.