bluuebunny/crossref_metadata_2025_split huggingface dataset:
PLAP expression is linked to invasive tumor growth in urothelial carcinoma of the bladder
Authors: Plage Henning , Furlano Kira , Hofbauer Sebastian , Roßner Florian , Schallenberg Simon , Elezkurtaj Sefer , Lennartz Maximilian , Marx Andreas , Samtleben Henrik , Fisch Margit , Rink Michael , Slojewski Marcin , Kaczmarek Krystian , Ecke Thorsten , Klatte Tobias , Koch Stefan , Adamini Nico , Minner Sarah , Simon Ronald , Sauter Guido , Weischenfeldt Joachim , Schlomm Thorsten , Horst David , Zecha Henrik , Kluth Martina , Weinberger Sarah 
Published: December 2024

Abstract
Purpose
Placental alkaline phosphatase (PLAP) is a protein with a poorly understood function that is normally only expressed in the placenta. In cancer, PLAP expression is a hallmark of germ cell neoplasms, but it can also occur in urothelial carcinoma. To evaluate the potential clinical significance of PLAP expression in bladder cancer,

Methods
PLAP protein was analyzed by immunohistochemistry in more than 2500 urothelial bladder carcinomas in a tissue microarray format.

Results
PLAP staining was absent in normal urothelial cells but was observed in 15.9% of urothelial carcinomas, including 282 (11.5%) with weak, 57 (2.3%) with moderate, and 51 (2.1%) with strong staining. PLAP positivity occurred in 4.1% of 413 pTa G2 low-grade, 10.2% of 176 pTa G2 high-grade, and 7.2% of 97 pTa G3 tumors (p = 0.0636). As compared to pTa tumors, the PLAP positivity rate was markedly higher in 1341 pT2-4 carcinomas (19.8%, p < 0.0001). Within pT2-4 carcinomas, PLAP staining was unrelated to pT, pN, grade, L-status, V-status, overall survival, recurrence-free survival, and cancer-specific survival (p > 0.25). However, PLAP positivity was linked to p16 positivity (p = 0.0185), GATA3 positivity (p < 0.0001), and p63 expression loss (p = 0.0456).

Conclusion
In summary, these data show that PLAP is expressed in a significant fraction of pT2-4 urothelial carcinomas, unrelated to cancer aggressiveness but associated with specific molecular features. Once anti-PLAP cancer drugs become effective, urothelial carcinoma is a candidate tumor entity for clinical evaluation.
Sand and dust storms control for sustainable anti-desertification: large-scale EICP-PVAc treatment field demonstration and insights
Authors: Wang Hengxing , Sun Xiaohao , Miao Linchang , Zhang Jizhou , Yin Wenhua , Wu Linyu 
Published: December 2024

AbstractSand and dust storms (SDS) have gained global recognition as severe natural disasters and are emerging as a significant public health concern. However, the current methods for SDS control have imitations in wide applications, necessitating the urgent need for effective alternatives. This study investigated the feasibility of integrating enzymatically induced carbonate precipitation-polyvinyl acetate (EICP-PVAc) treatment with traditional engineering devices (e.g., straw checkerboard barriers and sand control belts) to mitigate SDS through a large-scale field experiment. Four different treated zones were established and three different treatment states [spraying on a day without rainfall (SWR), spraying after rainfall, and spraying before rainfall ] were designed to compare treatment effects. Soil characteristics including pH, organic carbon, and NH3–N contents were measured in the treated areas, and environmental implications of the EICP-PVAc treatment were discussed. Results show that the EICP-PVAc treatment effectively ensured long-term wind-erosion resistance of field areas, irrespective of different zones and treatment states, thereby addressing the limitation of traditional methods in stabilizing shifting sands. Upon comparison, SWR treatments exhibited superior efficacy in controlling field SDS. Furthermore, the EICP-PVAc treatment increased organic carbon and NH3–N contents in the treated areas. In addition, by combining EICP-PVAc treatment with vegetation protection measures, challenges such as low plant survival rate and the generation of contaminant by-products can be effectively mitigated, showcasing promising application potential. The study contributes to the potential application of EICP-PVAc treatment for SDS control to achieve long-term sustainability in anti-desertification and ecosystem function restoration.
Emotionen als Ressource für die Analyse von professionellen Handlungssituationen
Authors: Unterkofler Ursula 
Published: December 2024

Zusammenfassung
Der Beitrag befasst sich mit der Frage, welche Bedeutung Emotionen im Ethnografischen Spiel haben, wie sie methodisch aufgegriffen werden können und welche Potenziale sich für die Analyse von Handlungssituationen und für Professionalisierungsprozesse von Studierenden ergeben. Hierfür wird zuerst das Ethnografische Spiel als Zugang zur Analyse von Handlungssituationen skizziert: Dokumentierte Handlungssituationen werden mit Studierenden nachgespielt und im Anschluss werden Erfahrungen, die die Studierenden dabei machen, reflektiert. Dabei wird der Fokus auch auf Emotionen gelegt. Anschließend werden Ziele des Ethnografischen Spiels sowie die Bedeutung von Emotionen im Analyseprozess diskutiert. Emotionen können als Anlass für Befremdungsprozesse genutzt werden – sowohl im Zuge der Selbstreflexion als auch bei der Rekonstruktion von Situationen. Schließlich wird die Arbeit mit Emotionen im Rahmen des Ethnografischen Spiels anhand eines verdichteten Beispiels aus der Lehrpraxis veranschaulicht. Dieses macht deutlich, dass der gezielte Einbezug von Emotionen Studierenden einen erleichterten Zugang zur Befremdung eigener Sichtweisen und damit zur Analyse von Handlungssituationen und deren Theoretisierung ermöglicht.
Familienorientierung in der Kita- und Schulsozialarbeit
Authors: Thielemann Nurdin 
Published: December 2024

Zusammenfassung
Die schrittweise Implementierung der Kita-Sozialarbeit wird sozialpolitisch mit den Erfolgen der Schulsozialarbeit begründet (Thielemann 2022a). Während die Schulsozialarbeit in Deutschland auf fast 50 Jahre zurückblicken kann, ist die Kita-Sozialarbeit seit ca. zehn Jahren im Aufschwung. Kita- und Schulsozialarbeit sollen in dem vorliegenden Beitrag in Hinblick auf Familien als ihre Adressat_innen und ihre generellen Ziele verglichen werden. Komm- und Gehstrukturen als etablierte Ansätze in der Sozialen Arbeit werden dabei für die Kita-Sozialarbeit und die Schulsozialarbeit betrachtet und am Beispiel von Familienzentren im Bereich der Kindertagesbetreuung und von Familiengrundschulzentren diskutiert. Diese Beispiele verweisen auf konkrete Felder, in denen Kita-Sozialarbeit und Schulsozialarbeit aktuell zu finden sind.
Diagnosis and Management of Pediatric Varicocele: A Modern Update for the Practicing Pediatrician
Authors: Bissette Randall G. , Edelson Mia P. , Campbell Kevin J. , Bayne Christopher E. 
Published: December 2024

Abstract
Purpose of Review
Pediatric varicoceles are common, yet the paucity of data on long-term fertility outcomes does not establish recommendations for conservative management and reassurance versus pediatric urology referral for consideration of surgical intervention. This review incorporates recent literature to generate pragmatic, objective methodology for the evaluation and management of pediatric varicoceles.

Recent Findings
The initial evaluation of pediatric varicoceles includes focused history, physical exam, and use of an orchidometer or ultrasound for volume assessment. In early puberty, asynchronous testicular growth may be transient and monitored serially via ultrasound. Further workup may include semen analysis (SA), ultrasound of spermatic veins to determine peak retrograde flow (PRF), and hormonal analysis. Pediatric varicoceles may be managed with observation and reassurance or referral to pediatric urology for consideration of surgical intervention. In patients presenting before Tanner V stage, management is typically expectant, with pain warranting referral. Definitive indications for referral once Tanner V is reached include pain, undesirable appearance, bilateral varicoceles, persistent testicular atrophy, low total testicular volume (TTV), elevated peak retrograde flow on Doppler ultrasonography, persistently low total mobile sperm count (TMSC) on repeat SA, or infertility.

Summary
Most pediatric and adolescent patients with varicocele may be reassured and monitored serially. Straightforward and objective assessment tools should be used when further workup is warranted, providing clear guidance on elevation of care from pediatricians to pediatric urologists.
Identifying employee engagement drivers using multilayer perceptron classifier and sensitivity analysis
Authors: Núñez-Sánchez José M. , Molina-Gómez Jesús , Mercadé-Melé Pere , Fernández-Miguélez Sergio M. 
Published: December 2024

AbstractEmployee engagement is increasingly important, as it can become a competitive advantage for companies, helping them increase productivity, attract talent and improve customer satisfaction. Numerous works have studied the drivers that encourage employee engagement and have developed models to identify them. However, the existing models have limitations, and the literature demands more research on the subject since the precision of the models still needs to improve. This paper presents a computational model that can estimate the drivers of employee engagement accurately. A sample of 205 Spanish employees was used, allowing us to consider a wide sectorial heterogeneity. Different methods have been applied to the sample under study to achieve a high-precision model, selecting drivers using the Multilayer Perceptron Classifier and quantifying the impact of the drivers with Sensitivity Analysis. The results obtained in this research present important implications for the managerial improvement of human resources departments by facilitating the design of strategies and policies that foster employee engagement, which significantly influences corporate results.
Pädagogik(en) der Nachhaltigkeit. Subjekt, Organisation und Gesellschaft im Anthropozän
Authors: Wendt Thomas 
Published: December 2024

Zusammenfassung
Der Beitrag entwirft eine erziehungswissenschaftliche Nachhaltigkeitsforschung, die das menschliche Subjekt, die Sozialform der Organisation und das beide einbettende Gesellschaftssystem als unterschiedliche Analyseebenen zueinander differenziert. Dazu werden in einem ersten Schritt Gesellschaftstheorien der (Nicht‑)Nachhaltigkeit analysiert und im Hinblick auf das etablierte gesellschaftstheoretische Diskursmuster der De- und Rezentrierung des Subjekts diskutiert. In der Gegenüberstellung individueller Lebenspraxis und gesellschaftlicher Infrastruktur spielt sich dieses dauerhaft ein, womit die gesellschaftsweite Verbreitung pädagogisch wirksamer Moralkommunikation einhergeht. Der Kontrast von Subjekt und Gesellschaft verstellt aber auch den Blick dafür, dass gesellschaftliche Kontinuitäten – und damit auch die (Nicht‑)Nachhaltigkeit der Gesellschaft – mit der Sozialform der Organisation verbunden sind. Die soziale Form der Organisation bietet sowohl eine Antwort auf die Frage nach den Ursachen gesellschaftlicher Nichtnachhaltigkeit wie sie Anknüpfungspunkte der Transformation vorhält. Diese bestehen nicht nur in einer organisational vermittelten Pädagogik der Dinge, sondern begründen sich auch dadurch, dass durch organisationale Strukturbildung eine sozial weitreichende Wirkung realisiert wird, die über subjektive Konsumentscheidungen oder Präferenzen des Lebensstils hinausreicht. Dass diese als Ergebnis der Ausdifferenzierung von Verhaltenserwartungen und Handlungsimperativen selbst genuin pädagogisch ist, verweist darauf, dass sich auch im Kontext der Nachhaltigkeitstransformation pädagogische Vermittlung und Aneignung nicht auf menschliche Interaktionen reduziert. Die pädagogische Wirkung überindividueller Formen der Strukturbildung stellt für eine erziehungswissenschaftliche Nachhaltigkeitsforschung eine Aufgabe in Theoriebildung, Empirie und Vermittlung dar.
Queering healthcare with technology?—Potentials of queer-feminist perspectives on self-tracking-technologies for diversity-sensitive healthcare
Authors: Ellerich-Groppe Niklas , Ott Tabea , Puzio Anna , Weigold Stefanie , Müller Regina 
Published: December 2024

AbstractSelf-tracking-technologies can serve as a prominent example of how digital technologies put to test established practices, institutions, and structures of medicine and healthcare. While proponents emphasize the potentials, e.g., for individualized healthcare and new research data, opponents stress the risk that these technologies will reinforce gender-related inequalities.While this has been made clear from—often intersectional—feminist perspectives since the introduction of such technologies, we aim to provide a queer-feminist perspective on self-tracking applications in healthcare by analyzing three concrete cases. In this way, we want to show why such a perspective is helpful in assessing self-tracking technologies and how such a perspective might contribute to a queering of healthcare.After a short introduction to self-tracking in healthcare and the corresponding risks of reproducing gender-related inequalities, we introduce queer bioethics as a methodology to examine structural discrimination and marginalization in bioethical research. We apply this framework in the analysis of three exemplary self-tracking applications from the areas of nutrition/fitness, reproductive health, and mental health. In the subsequent discussion of these results against the backdrop of already existing queer-sensitive technologies, we identify an equal access, a subversive design, an inclusive database, and a diversity-sensitive and discriminatory-critical definition of purposes as well as individualized usage possibilities as first possible starting points for a queering of self-tracking applications. Finally, we draw conclusions, how such a critical perspective on self-tracking applications might also contribute to a queering of the healthcare system at a structural level.
Grapevine viruses: Did you say more than a hundred?
Authors: Fuchs Marc 
Published: December 2024

Abstract
Grapevine virology is well rooted in history, with virus-like symptoms described in the literature as early as the 18th century, and the identification and characterization of viruses associated with viral diseases in the later half of the 20th century. At the dawn of the 21st century and the progressive advent of high-throughput sequencing methodologies followed by their rapid global adoption for virus discovery and annotation of the viral metagenome, the landscape of grapevine virology has rapidly changed. Consequently, the number of novel viruses identified in grapevines (Vitis spp.) has exponentially increased over the past decade and a half. High-throughput sequencing has also been elegantly used for revisiting the existence of a virus that had been allegedly associated with a grapevine disease to only empirically rule it out as a bona fide virus of the grapevine. As a result, the number of grapevine viruses sometimes dwindles, making their timely itemization essential for the community of virologists, as well as growers, extension educators, grapevine nurseries, diagnosticians, service providers, and regulators alike. Here, as of the preparation of this article, 102 viruses have been identified in grapevines worldwide. These viruses are exemplar isolates of species that belong to 44 genera in 21 virus families. The more than a hundred viruses solidifies the ranking of Vitis spp. as the cultivated crop hosting the most viruses.
Extensible portal frame bridge synthetic dataset for structural semantic segmentation
Authors: Fountoukidou Tatiana , Tkachenko Iuliia , Poli Benjamin , Miguet Serge 
Published: December 2024

AbstractA number of bridges have collapsed around the world over the past years, with detrimental consequences on safety and traffic. To a large extend, such failures can be prevented by regular bridge inspections and maintenance, tasks that fall in the general category of structural health monitoring (SHM). Those procedures are time and labor consuming, which partly accounts for their neglect. Computer vision and artificial intelligence (AI) methods have the potential to ease this burden, by fully or partially automating bridge monitoring. A critical step in this automation is the identification of a bridge’s structural components. In this work, we propose an extensible synthetic dataset for structural component semantic segmentation of portal frame bridges (PFBridge). We first create a 3 dimensional (3D) generic mesh representing the bridge geometry, while respecting a set of rules. The definition of new, or the extension of the existing rules can adjust the dataset to specific needs. We then add textures and other realistic elements to the model, and create an automatically annotated synthetic dataset. The synthetic dataset is used in order to train a deep semantic segmentation model to identify bridge components on bridge images. The amount of available real images is not sufficient to entirely train such a model, but is used to refined the model trained on the synthetic data. We evaluate the contribution of the dataset to semantic segmentation by training several segmentation models on almost 2,000 synthetic images and then finetuning with 88 real images. The results show an increase of 28% on the F1-score when the synthetic dataset is used. To demonstrate a potential use case, the model is integrated in a 3D point cloud capturing system, producing an annotated point cloud where each point is associated with a semantic category (structural component). Such a point cloud can then be used in order to facilitate the generation of a bridge’s digital twin.
International migration, remittances, and remaining households: evidence from a trade embargo
Authors: Al-Malk Afnan , Maystadt Jean-François , Navarro Paniagua Maria 
Published: December 2024

AbstractIdentifying the impact of remittances on household members remaining behind is difficult due to selection into migration. In this paper, we exploit an unexpected embargo on Qatar, the second major destination among Nepali migrants. Using longitudinal data on about 1,500 Nepali households with migrants prior to the embargo, we assess how this shock translates into changes in remittances and development outcomes. We find a 56% reduction in remittances for households with a migrant in Qatar. At least in the months immediately after the shock, such a fall in remittances does not seem to translate into recipient household's welfare. However, we cannot exclude that such effect might materialize in the medium run. That is particularly true for poor and credit-constrained households, especially vulnerable to the remittance windfall and lacking the ability to move their migrants or other household members to other destinations.
What the actual ….? Tensions in the science–business–policy interface for global sustainability
Authors: Sjåfjell Beate , Cornell Sarah E. 
Published: December 2024

AbstractInteractions of global change science, business and policymakers play a crucial role in shaping today’s regulatory frameworks for corporate sustainability. Our research question is why sustainability might actually be undermined by the ways that some prominent interfaces are informing corporate sustainability. Concentrating on ‘science-based’ initiatives that prescribe quantitative target-setting, business-driven task forces that define frameworks for businesses to assess and disclose information on strategies and targets, and the European Union (EU) as a supranational policymaking power, we scrutinise concepts, debates and developments involving these three globally influential non-state actors.Although the conceptualisation of sustainability as a safe and just space is well established in academic and policy contexts, key premises are being lost in translation at science–business–policy interfaces, delaying or actually deflecting regulation of business. We call for science–business–policy interfaces to conceptualise corporate sustainability as business contributing to mitigating planetary biophysical pressures and securing social foundations worldwide. In this context, we argue that the research basis for ‘safe and just’ cannot be reduced to simplistic and separate quantifications. Treating global sustainability goals as an itemised checklist for business action, and using scientifically narrow and overly reductive approaches to quantification and target-setting, fall short of this systemic understanding of corporate sustainability.The recognition of risks of unsustainability and the desire for sustainable value creation can act as drivers for change. Paradoxically, today’s business concept of ‘sustainable value’ actually undermines the potential for transformations to sustainability, and the dominant finance-driven treatment of ‘sustainability risks’ fall far short of capturing the hazards of continued unsustainabilities. In examining what the EU is actually doing, we find that the EU’s unprecedented attempts at regulating business for sustainability are being thwarted through powerful lobby interests, the outcomes of the science–business–policy interface, and the EU’s own fixation on economic growth and finance.Sustainability involves dealing justly with today’s unsafe conditions, and dealing safely with unjust conditions. This requires radically more innovative responses from business, truly sustainability-oriented adaptive leadership from policymakers, and critically reflexive transdisciplinary engagement by a much wider range of sustainability scholars.
The EU Vaccines Strategy: A mixed bag of achievements and discontent
Authors: Arroyo Jane , Del Giovane Chiara , Mizsei Berta , Vu Hien , Yeung Timothy Yu-Cheong 
Published: December 2024

Abstract
During the COVID-19 pandemic, the European Union (EU) observed a major centralisation of competence in public health policy – the EU Vaccines Strategy. Yet increased centralisation or integration is not always desirable because the EU lacks a layer of democratic control to ensure transparency and accountability. This feature highlights the need to better understand and assess the EU’s actions during the pandemic. This paper aims to assess the effectiveness of the EU Vaccines Strategy and contributes to the wider debate on the centralisation of power at Union level. The joint procurement of COVID-19 vaccines is considered a success, as it avoided a “vaccine scramble” by the EU Member States. However, the fact that the Member States were obliged to purchase more than they needed and the lack of transparency in the negotiations with companies on the procurement of vaccines have raised questions about the integrity of the Commission’s exercise of executive power.