bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vergleich der neuen Erdbebengefährdungskarten der Schweiz, Deutschlands, Österreichs und Frankreichs für die Nationalen Anhänge zum Eurocode 8
Authors: Grünthal Gottfried 
Published: August 2020

AbstractDer Vergleich der neuen Erdbebengefährdungskarten für die Schweiz, Deutschland, Österreich und für Frankreich, die für die Nationalen Anhänge zum Eurocode 8 entwickelt wurden, ist Gegenstand dieser Studie. Die vorgestellte gemeinsame Karte überdeckt den südlichen Teil Deutschlands samt angrenzender Gebiete der genannten Nachbarländer. Die Parametrisierung der Karte erfolgt für die Spitzenbodenbeschleunigung, für eine mittlere Wiederholungsperiode von 475 Jahren, für Medianwerte und für einen Untergrund mit einer mittleren Scherwellengeschwindigkeit der obersten 30 m von 800 m/s. Entlang des Grenzverlaufs zwischen Deutschland und den südlichen Nachbarländern zeigen die Konturlinien der unabhängig voneinander berechneten Erdbebengefährdungskarten insgesamt eine erstaunlich gute Übereinstimmung. Das gilt insbesondere für Gebiete relativ erhöhter Erdbebengefährdung. Diese gute bis sehr gute Übereinstimmung kann als Indiz für die Belastbarkeit der Einschätzungen angesehen werden.
Unterschiede, Beziehungen und Gemeinsamkeiten der Erdbebenkarten nach bisherigem und neuem Nationalen Anhang zum Eurocode 8
Authors: Grünthal Gottfried , Bosse Christian 
Published: August 2020

AbstractDie Karte der spektralen elastischen Antwortbodenbeschleunigungen zum Entwurf des neuen Nationalen Anhangs zum EC 8 (E DIN EN 1998‐1/NA:2018‐10) hat in Anwenderkreisen einige Diskussionen ausgelöst. Diese bezogen sich insbesondere auf den Vergleich zur Erdbebenzonenkarte des bisherigen Nationalen Anhangs (DIN EN 1998‐1/NA:2011‐01). Grundsätzlich ist zu betonen, dass ein direkter Zusammenhang zwischen den beiden Karten nicht hergestellt werden kann, da diese auf sehr unterschiedlichen Parametrisierungen basieren. Um für weitere Diskussionen eine sachliche Grundlage zu schaffen, werden in diesem Beitrag die grundlegenden Charakteristika beider Berechnungsmodelle, d. h. zu den Erdbebenkarten des bisherigen und des neuen NA, gegenübergestellt. Des Weiteren werden vier Varianten vorgestellt, wie zumindest auf indirektem Wege die beiden unterschiedlichen Kartentypen in Beziehung gesetzt werden können. Im Ergebnis zeigen die Varianten, dass sie einem gemeinsamen Trend folgen.
Encapsulating Oxygen‐Deficient TiNb24O62 Microspheres by N‐Doped Carbon Nanolayer Boosts Capacity and Stability of Lithium‐Ion Battery
Authors: Jiang Jiangmin , Li Zhiwei , Nie Guangdi , Nie Ping , Pan Zhenghui , Kou Zongkui , Chen Qiang , Zhu Qi , Dou Hui , Zhang Xiaogang , Wang John 
Published: August 2020

AbstractMost of the insertion anode materials are approaching their specific capacity limitations. TiNb24O62, combining the merits of high theoretical capacity, large working potential and excellent safety, is a promising candidate for lithium‐ion batteries (LIBs). However, its poor intrinsic conductivity and relatively sluggish reaction kinetics hinder its wide applications. Herein, we encapsulate the oxygen‐deficient TiNb24O62 microspheres by highly conductive N‐doped carbon nanolayer (DTNO@NC), where TiNb24O62 is purposely made to exhibit oxygen deficiency, by aerosol spray followed by co‐carbonization of the electronically coupled polydopamine (PDA) coating layer. The oxygen‐deficient engineering for TiNb24O62 improves the intrinsic conductivity and active sites, while the PDA derived N‐doped carbon coating layer not only stabilizes the interface between the electrode and electrolyte, but also further enhances the overall conductivity. As a result, the as‐fabricated DTNO@NC electrode delivers excellent Li+ ion storage capacity (270 mAh g−1 at 0.1 A g−1) and superior cycling lifespan (capacity retention of 90 % after 1000 cycles). This work demonstrates the effectiveness of integrating an oxygen‐deficient structure of intercalation‐type anode material with a carbon encapsulating nanolayer in enabling the overall energy storage performance.
An evaluation of and preference for variations of the Good Behavior Game with students with autism
Authors: Vargo Kristina , Brown Christina 
Published: August 2020

AbstractThe Good Behavior Game (GBG) has been implemented in numerous classrooms to decrease problem behavior. Despite the vast amount of literature, the effects of the inclusion of technology on disruptive behavior and student preference with students with autism have not been studied extensively. In this study, we compared the efficacy of the traditional GBG with technology‐enhanced GBG variations (ClassDoJo and ClassBadges) using a multielement design embedded within a reversal design with six male high school students diagnosed with autism. Results showed that all three GBG variations were similarly effective in decreasing disruptive behaviors. We then assessed individual preference for the GBG variations using a group‐oriented concurrent‐chains arrangement. All students demonstrated repeated preference for one GBG variation. These findings support the inclusion of technology‐enhanced GBG variations in special education classrooms with students with autism. Additionally, these results provide further evidence of the utility and applicability of the group‐oriented concurrent‐chains procedure.
Exosome: From leukemia progression to a novel therapeutic approach in leukemia treatment
Authors: Gholipour Elham , Sarvarian Parisa , Samadi Parisa , Talebi Mehdi , Movassaghpour Aliakbar , Motavalli Roza , Hojjat‐Farsangi Mohammad , Yousefi Mehdi 
Published: August 2020

AbstractExosomes, as small vesicles, are released by tumor cells and tumor microenvironment (cells and function as key intercellular mediators and effects on different processes including tumorigenesis, angiogenesis, drug resistance, and evasion from immune system. These functions are due to exosomes' biomolecules which make them as efficient markers in early diagnosis of the disease. Also, exosomes have been recently applied in vaccination. The potential role of exosomes in immune response toward leukemic cells makes them efficient immunotherapeutic agents treating leukemia. Furthermore, variations in exosomes contents make them beneficial to be used in treating different diseases. This review introduces the role of exosomes in the development of hematological malignancies and evaluates their functional role in the treatment of these malignancies.
Stay calm and focus on the learning outcomes: Tools for taking biophysical chemistry online
Authors: Ballester Maria , Van Hoozen Brian , Sikora Arthur K. 
Published: August 2020

AbstractCourse specific learning outcomes are an important tool to define the scope of a course and can be very helpful when designing experiments and assessments. With slight modification, these learning outcomes can serve as a guide when transitioning to the distance learning format especially in courses with a traditional lab. Here we present such an example for the biophysical chemistry course.
Amyotrophic lateral sclerosis care in Saudi Arabia: A survey of providers’ perceptions
Authors: Abuzinadah Ahmad R. , AlShareef Aysha A. , AlKutbi Abdullah , Bamaga Ahmed K. , Alshehri Ali , Algahtani Hussein , Cupler Edward , Alanazy Mohammed H. 
Published: August 2020

AbstractObjectiveProvision of care for patients with amyotrophic lateral sclerosis (ALS) is complex and requires the contribution of multiple healthcare professionals. Several international ALS care measures were developed to ensure optimal care for ALS patients. We looked at the rate of inconsistency in providing standard ALS care measures in Saudi Arabia (SA).MethodsA 5‐point response survey was distributed to practicing neurologists in SA. They were asked to grade their perceived consistency of accessibility for 19 items of ALS care measures at their center. The list of ALS care measures items was derived from international ALS guidelines.ResultsThe response rate from neurologists was 47.3% (62/131), and the responses of 39 neurologists who follow ALS cases were included. Most of the selected ALS care measure items, 63.1% (12/19), were perceived by 50% or more of the ALS care providers to be not consistently accessible to their patients. The perception of ALS care providers of the inconsistent accessibility for ALS patients to ALS care measures was high for communication devices (92.3%), supportive equipment such as motorized wheelchairs (76.9%), end‐of‐life discussion (74.4%), and respiratory monitoring (66.7%).ConclusionOur data show that ALS patients in SA do not have consistent access to the recommended ALS care measures.
Corporate governance reform and overstatement of compliance: Illustrations from an emerging economy
Authors: Islam Md Tariqul , Rahman Mahfuzur , Saha Shrabani 
Published: August 2020

AbstractThis paper examines the effect of corporate governance (CG) reform on the window dressing of compliance in the context of an emerging economy, Bangladesh. In particular, this study investigates the true level of compliance concerning the three internal governance mechanisms, such as board independence, CEO duality and formation of audit committee before and after the reform enacts. By using content analysis of 194 non‐financial listed companies between 2007 and 2017, this study observes the extent of overstatements in compliance statements along with the nature of firms that are involved in it. After the regulatory shift in 2012, requiring more independent directors into the board and external certification of compliance statements, it was found that the extent of window dressing in compliance statements declined considerably over time. Moreover, government firms are found to make more proportionate overstatements compared to family and others (non‐family and foreign companies). counterparts. The fall in window dressing indicates that the companies' fabricating efforts in CG compliance are challenged by the regulatory change in a formal legal environment.
Customizable and scalable automated assessment of C/C++ programming assignments
Authors: Delgado‐Pérez Pedro , Medina‐Bulo Inmaculada 
Published: August 2020

AbstractThe correction of exercises in programming courses is a laborious task that has traditionally been performed in a manual way. This situation, in turn, delays the access by students to feedback that can contribute significantly to their training as future professionals. Over the years, several approaches have been proposed to automate the assessment of students' programs. Static analysis is a known technique that can partially simulate the process of manual code review performed by lecturers. As such, it is a plausible option to assess whether students' solutions meet the requirements imposed on the assignments. However, implementing a personalized analysis beyond the rules included in existing tools may be a complex task for the lecturer without a mechanism that guides the work. In this paper, we present a method to provide automated and specific feedback to immediately inform students about their mistakes in programming courses. To that end, we developed the CAC++ library, which enables constructing tailored static analysis programs for C/C++ practices. The library allows for great flexibility and personalization of verifications to adjust them to each particular task, overcoming the limitations of most of the existing assessment tools. Our approach to providing specific feedback has been evaluated for a period of three academic years in a course related to object‐oriented programming. The library allowed lecturers to reduce the size of the static analysis programs developed for this course. During this period, the academic results improved and undergraduates positively valued the aid offered when undertaking the implementation of assignments.
The impact of routine Edmonton Symptom Assessment System (ESAS) use on overall survival in cancer patients: Results of a population‐based retrospective matched cohort analysis
Authors: Barbera Lisa , Sutradhar Rinku , Seow Hsien , Mittmann Nicole , Howell Doris , Earle Craig C. , Li Qing , Thiruchelvam Deva 
Published: August 2020

AbstractBackgroundThe Edmonton Symptom Assessment System (ESAS) is a validated instrument whose use has been standardized in the Ontario cancer system to measure symptoms among ambulatory cancer patients. The objective was to examine the effect of ESAS exposure on overall survival. We hypothesized, a priori, that patients exposed to ESAS would have higher rates of overall survival than those who were not exposed.MethodsThis was a retrospective matched cohort study of adults diagnosed with cancer between 2007 and 2015. Patients were considered exposed if they were screened with ESAS at least once during the study period. Their first ESAS screening date defined the index date. Each exposed patient was matched randomly to a cancer patient without ESAS using a combination of hard matching (4 variables) and propensity score matching (14 variables). Kaplan‐Meier curves and multivariable Cox regression were used to evaluate the impact of ESAS exposure on survival.ResultsThere were 128,893 pairs well matched on all baseline characteristics. The probability of survival within the first 5 years was higher among those exposed to ESAS compared to those who were not (81.9% vs. 76.4% at 1 year, 68.3% vs. 66.1% at 3 years, 61.9% vs. 61.4% at 5 years, P‐value < .0001). In the multivariable Cox regression model, ESAS was significantly associated with a decreased mortality risk (HR: 0.48, 95% CI: 0.47‐0.49).ConclusionsOur results show that ESAS exposure is associated with improved survival in cancer patients. This provides real world evidence of the impact of routine symptom assessment in cancer care.
Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan‐cancer
Authors: Chen Zhanghan , Huang Jie , Feng Yanling , Li Zehuan , Jiang Ying 
Published: August 2020

AbstractBackgroundThe pan‐cancer analysis has recently brought us into a novel level of cancer research. Nowadays, the Circular RNAs (circRNAs) is becoming increasingly important in the occurrence and progression of tumors. Nevertheless, the specific expression patterns and functions of circRNAs in the pan‐cancer remains unclear. Here we aimed to explore the expression patterns and functions of circRNAs in pan‐cancer.MethodsWe combined our microarray with seven circRNA arrays from the Gene Expression Omnibus (GEO) database and transcriptome profiles were acquired from The Cancer Genome Atlas (TCGA) database. A circRNA‐miRNA‐mRNA network was created and analyzed using multiple bioinformatic approaches including Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, Search Tool for the Retrieval of Interacting Genes (STRING) database, cytoHubba and MCODE app. Cell function assays including CCK‐8 analysis, colony formation, and transwell assay were used to explore pan‐circRNAs’ functions.ResultsA panel of 6 circRNAs, 11 miRNAs, and 318 mRNAs was found to be differentially expressed (DE) in pan‐cancer. A circRNA‐miRNA‐mRNA network was also constructed. Then, a circRNA‐miRNA‐hub gene network was created according to 5 pan‐circRNAs, 8 pan‐miRNAs, and 16 pan‐mRNAs. Enrichment analysis pointed out the possible association of DEmRNAs with pan‐cancer is transcriptional misregulation in cancer. Overexpression of hsa_circ_0004639 and silence of hsa_circ_0008310 can inhibit the malignant biological properties of cancer cells.ConclusionsSix pan‐circRNAs were discovered and their regulating mechanisms were predicted. Those findings together will give a new insight into pan‐cancer research and present potential therapy targeting as well as promising biomarkers.
Singlet‐Oxygen Generation by Peroxidases and Peroxygenases for Chemoenzymatic Synthesis
Authors: Ingenbosch Kim N. , Quint Stephan , Dyllick‐Brenzinger Melanie , Wunschik Dennis S. , Kiebist Jan , Süss Philipp , Liebelt Ute , Zuhse Ralf , Menyes Ulf , Scheibner Katrin , Mayer Christian , Opwis Klaus , Gutmann Jochen S. , Hoffmann‐Jacobsen Kerstin 
Published: August 2020

AbstractSinglet oxygen is a reactive oxygen species undesired in living cells but a rare and valuable reagent in chemical synthesis. We present a fluorescence spectroscopic analysis of the singlet‐oxygen formation activity of commercial peroxidases and novel peroxygenases. Singlet‐oxygen sensor green (SOSG) is used as fluorogenic singlet oxygen trap. Establishing a kinetic model for the reaction cascade to the fluorescent SOSG endoperoxide permits a kinetic analysis of enzymatic singlet‐oxygen formation. All peroxidases and peroxygenases show singlet‐oxygen formation. No singlet oxygen activity could be found for any catalase under investigation. Substrate inhibition is observed for all reactive enzymes. The commercial dye‐decolorizing peroxidase industrially used for dairy bleaching shows the highest singlet‐oxygen activity and the lowest inhibition. This enzyme was immobilized on a textile carrier and successfully applied for a chemical synthesis. Here, ascaridole was synthesized via enzymatically produced singlet oxygen.
Transradial versus transfemoral access: The dispute continues
Authors: Postalian Alexander , Krajcer Zvonimir 
Published: August 2020

Key Points
Transradial access was associated with fewer vascular complications than transfemoral access assisted by with vessel plug and suture closure devices.
Confounding variables, such as case complexity and sheath size used, affect the external validity of the results.
Further research is required to establish best access practices. In the meantime, radial artery access appears to be the safer approach when technically feasible.
Drug‐eluting stents in diabetic patients: Are we still treading water?
Authors: Chiarito Mauro , Mehran Roxana 
Published: August 2020

Key Points
Diabetic patients are frequently affected by coronary artery disease (CAD) and are at increased risk of CAD‐related adverse events, even after drug‐eluting stent (DES) implantation. If currently available DES have similar safety and efficacy in diabetic and nondiabetic patients is still debated.
This prospective, multicenter registry showed similar 3‐year outcome in patients undergoing different DES implantation, although diabetic patients, especially those requiring insulin treatment, had significantly higher risk of adverse events than nondiabetic patients.
Specific efforts to improve the performance of DES in diabetic patients are mandatory to adequately address the unsolved issue of diabetic patients affected by CAD.
Impella RP for treatment of right ventricular shock: Appropriate unloading never gets old
Authors: Goldstein James A. , Hanson Ivan 
Published: August 2020

Key Points
Rapid restoration of hemodynamics is key to successful shock management.
The failing right ventricular (RV) is resilient and recovers if hemodynamics are supported while the underlying insulting cause is alleviated.
Inotropic/vasopressor drugs constitute a “double‐edged sword” that augment hemodynamics, but exacerbate myocardial and multiorgan injury.
Impella RP mechanical support for RV shock stabilizes hemodynamics and is associated with favorable clinical outcomes.
Radial artery intervention: Facile for you is best for me, too
Authors: Butman Samuel M. 
Published: August 2020

Key Points
If you have transitioned to the radial artery as the preferred approach, congratulations.
If you are in training or currently transitioning, good for you, too. Your patient satisfaction scores are going to rise, and complications will be less frequent.
If you are still a femoral first, you are as old or older than me, and you should master this approach soon before you retire. Left radial approach is pretty much just like femoral, but with fewer complications.
TAVR patients count on their thrombocytes: Platelets count is accountable for the outcomes!
Authors: Oliveira Fredric Assis , Lemos Pedro A. 
Published: August 2020

Key Points
Chronic thrombocytopenia is frequent in patients undergoing TAVR in the real world.
Chronic thrombocytopenia is associated with worse in‐hospital outcomes after TAVR.
Future research is necessary to establish a better way of conducting and monitoring these patients.
Impact of chronic kidney disease on in‐hospital outcomes and readmission rate after edge‐to‐edge transcatheter mitral valve repair
Authors: Sawalha Khalid , Al‐Akchar Mohammad , Ibrahim Abdisamad , Buhnerkempe Michael , Koester Cameron , Salih Mohsin , Bhattarai Mukul , Tandan Nitin , Bhatt Deepak L. , Hafiz Abdul Moiz 
Published: August 2020

AbstractBackgroundTranscatheter mitral valve repair (TMVR) is a treatment option for patients with 3+ or greater mitral regurgitation who cannot undergo mitral valve surgery. Outcomes in patients with chronic kidney disease (CKD) and end stage renal disease (ESRD) are unclear. We sought to evaluate the TMVR in‐hospital outcomes, readmission rates and its impact on kidney function.MethodsData from 2016 National Readmission Database was used to obtain all patients who underwent TMVR. Patients were classified by their CKD status: no CKD, CKD, or ESRD. The primary outcomes were: in‐hospital mortality, 30‐ and 90‐day readmission rate, and change in CKD status on readmission. Multivariable logistic regression analysis was used to assess in‐hospital, readmission outcomes and kidney function stage.ResultsA total of 4,645 patients were assessed (mean age 78.5 ± 10.3 years). In‐hospital mortality was higher in patients with CKD (4.0%, odds ratio [OR]:2.01 [95% CI, confidence interval: 1.27–3.18]) and ESRD (6.6%, OR: 6.38 [95% CI: 1.49–27.36]) compared with non‐CKD (2.4%). 30‐day readmission rate was higher in ESRD versus non‐CKD patients (17.8% vs. 10.4%, OR: 2.24 [95% CI: 1.30–3.87]) as was 90‐day readmission (41.2% vs. 21% OR: 2.51 [95% CI:1.70–3.72]). Kidney function improved in 25% of patients with CKD stage 3 and in 50% with CKD stage 4–5 at 30‐and 90‐day readmission. Incidence of AKI, major bleeding, and respiratory failure were higher in CKD group.ConclusionsPatients with CKD and ESRD have worse outcomes and higher readmission rate after TMVR. In patients who were readmitted after TMVR, renal function improved in some patients, suggesting that TMVR could potentially improve CKD stage.
A unique case of hemolytic‐uremic syndrome secondary to enteropathogenic E Coli
Authors: Nelson Blessie Elizabeth , Hong Angelina , Iqbal Fatima , Jana Bagi 
Published: August 2020

AbstractCausative factors of HUS due to infection are not limited to classic EHEC and Shigella infection. Understanding the effects of EPEC‐related HUS and its complications is imperative for early diagnosis and treatment to mitigate long‐term sequelae.
Noble‐metal‐free MOF Derived ZnS/CeO2 Decorated with CuS Cocatalyst Photocatalyst with Efficient Photocatalytic Hydrogen Production Character
Authors: Wang Xiao‐li , Xiao Yang , Yu Hui , Yang Ying , Dong Xiang‐ting , Xia Long 
Published: August 2020

AbstractInspired by the rich morphology of ZnO and cation‐exchange technology, regular dodecahedron‐like CeO2/ZnO was obtained by the calcination of Ce doped ZIF‐8 precursor in this study, and CeO2/ZnS was obtained by the in‐situ vulcanization of CeO2/ZnO. This design not only maintained the morphology of ZIF‐8, but also enhanced the oxidation‐reduction capacity of the catalyst. When the Ce content was 10 wt %, 10‐CeO2/ZnS sample showed the best photocatalytic hydrogen production performance in all X−CeO2/ZnS samples. Loading of co‐catalysts can effectively enhance the surface hydrogen reduction in photocatalytic water splitting by introducing a positive Schottky barrier. CuS was regarded as a promising cocatalyst to replace the noble metals due to its low cost and equivalent or even better performance. The in‐situ cation exchange method was used to load co‐catalyst CuS on the 10‐CeO2/ZnS composites to obtain the 10‐CeO2/ZnS‐CuS composites which had the large specific surface area, regular dodecahedral structure and much excellent photolysis of water to produce hydrogen characters. This work provided a new strategy for the advantages combining of co‐catalyst, p‐n junction as well as the porous structure to enhance the photocatalytic characters.