bluuebunny/crossref_metadata_2025_split huggingface dataset:
Krise, kærlighed og katastrofe. Den knap så opbyggelige rejses erotik i Jan Sonnergaards roman Frysende våde vejbaner
Authors: Wenusch Monica 
Published: December 2019

Abstract
In Jan Sonnergaard’s novel Frysende våde vejbaner (2015) the interconnection between travelling and eroticism constitutes a crucial element of the text’s structure. On his journey the novel’s main protagonist, Jesper, a middle-aged man, experiences liberation and relief from his everyday frustrations through erotic indulgence. The journey, the indulgence as well as the erotic love are capable of healing Jesper from his severe existential crisis. Nevertheless, Jesper is heading towards disaster, as his new life eventually turns out to be based on his girlfriend’s well-thought-out lies and her deception. Consequently, Jesper’s regained optimism falls apart again.
From a narrative point-of-view the article focuses on, how the aspects of travelling and erotic love are interconnected. The obsersations regarding the implications of eroticism in the novel are primarily based on Plato’s discussions of eros (vs. logos), as presented by the Greek philosopher in his Symposion. Furthermore, the significance of the space defined by travel for the experience of eroticism is examined. A number of significant contrasts inherent in the novel (logos and eros, home and abroad, the private and the public space) is also made part of the close-reading-analysis.
”Jeg kunde for Længsel ej sove” Holger Drachmann og den erotiske rejse
Authors: van der Liet Henk 
Published: December 2019

Abstract
Inspired by the spatial turn in literary criticism, this article seeks to combine a traditional biographical approach of the versatile oeuvre of the late 19th Century Danish poet, painter and bon vivant Holger Drachmann (1846–1908), with a space-oriented perspective. One of the key concepts of the Scandinavian literature of the latter half of the 19th Century, the era of the so-called Modern Breakthrough, was to promote a literature that dealt with contemporary social issues; at the same time, many of the artists who adhered to this program turned their backs on everyday routine, by frequently travelling and living abroad for long periods. Especially Southern Europe, and in particular Italy was a favorite destination. In Drachmann’s oeuvre too, the lure of the South is omnipresent, but his initial infatuation with Italy shifts radically between his first (1867) and second (1876) journey to the country, from an Orientalist notion of Italy as an eroticised Nirvana, to a horrendously degenerate country. This case study proposes a spatial reading of one of Drachmann’s still well-known poems, ”Sakuntala” (1879), where the lure of travel, exoticism and erotic enticement are brought together in a poem, in which travel is a mere metaphor for the state of mind in which exotic landscapes morph into erotic spaces, while eroticist desire remains forever unfulfilled.
Power Distribution Systems Using Bit-Shift Operator Based MOSOA
Authors: Kumar Deepak , Ghosh Ayan , Samantaray S.R. , Jha Sumit Kr. 
Published: December 2019

Abstract
This paper presents a new approach based on the application of a bit-shift operator based multi-objective seeker-optimization-algorithm (BS-MOSOA) for designing of combined primary and secondary power distribution system (CPDS) considering both system cost and reliability. In number of researches works the planning of secondary power distribution system (PDS) has not been considered for planning strategy. However, it is observed that the total investment and operational cost components of secondary PDS plays an important role in the overall system cost. Thus, in this proposed research a CPDS has been considered for comprehensive planning of complex PDS. Furthermore, a reliability index called Contingency-load-loss-index is used for the reliability assessment of the network. The algorithm uses a modified version of seeker-optimization-algorithm (SOA), which is based on the status of changing switches and shift operator to generate a group of non-dominated solutions. Also, fuzzy theory approach is used for selection of most suitable solution among the non-dominated solutions from the obtained Pareto-front. The proposed method is illustrated on a real test case consist of a residential primary and secondary network of 75 electrical nodes. Furthermore, a qualitative comparison is made with existing traditional and classical methodologies, to show the efficacy of the proposed planning approach.
Improving solubility and dissolution of meloxicam by solid dispersion using hydroxypropyl methylcellulose 2910 3 cps and nicotinamide
Authors: Fathanah Ana , Setyawan Dwi , Sari Retno 
Published: December 2019

Abstract

Background
Solid dispersion (SD) represents a good method for enhancing the solubility of poorly water-soluble drugs. Meloxicam (MLX), a nonsteroidal anti-inflammatory drug has poor solubility in water. Hydroxypropyl methylcellulose (HPMC) 2910 3 cps, a hydrophilic carrier and nicotinamide (NC), a hydrotropic agent can be used as matrix of SD. The aim of this study is to investigate the effect of HPMC 2910 3 cps and NC as SD matrix on the solubility and dissolution rate of MLX.

Methods
The SD of MLX was prepared by solvent evaporation method using methanol as solvent. The SD formulations composed of HPMC and NC in different ratios (1:1:1, 1:1:2, 1:2:1, 1:2:2). The physical state of MLX SD were characterized by Differential Thermal Analyzer (DTA), Fourier Transform Infrared Spectroscopy, powder X-ray diffractometer (PXRD), Scanning Electron Microscopy (SEM). The solubility and dissolution of the MLX SD were also evaluated.

Results
The results of differential thermal analysis (DTA) showed that the melting point of MLX SD was lower than MLX further the X-ray diffractogram showed a decrease of the crystallinity of MLX in SD. Those indicated that MLX was dispersed molecularly in SD. The SD showed a widening transmission peak at 3000–3500 cm−1 which resembled the peak of pure MLX transmission. It indicated that intermolecular hydrogen bonds were formed between MLX, HPMC, and NC. The solubility and the dissolution efficiency (ED60) of SD with MLX-HPMC 2910 3 cps-NC = 1:2:1 increased 3.59 times and 1.50 times higher then MLX substance.

Conclusions
MLX-HPMC-NC SD system increased the solubility and dissolution of MLX. The SD with MLX-HPMC 2910 3 cps-NC ratio of 1:2:1 had the highest solubility and ED60 compared to the other SD formulas.
The prescription patterns of second-generation antipsychotics in schizophrenia outpatient setting
Authors: Julaeha Julaeha , Athiyah Umi , Hermansyah Andi 
Published: December 2019

Abstract

Background
Schizophrenia is a chronic disorder that requires long-term treatment to achieve symptom remission and quality of life improvement. Antipsychotic medications are primary treatments for schizophrenia patients. Second-generation antipsychotics (SGAs) have been recognized as first-line drugs in the treatment of schizophrenia. This study aimed at determining the prescription patterns of SGAs in schizophrenia outpatients in the National Mental Hospital in Indonesia.

Methods
A retrospective study with descriptive analysis was conducted between October and December 2018, exclusive to data of the patients with schizophrenia only. Data were collected from the prescription records of schizophrenia outpatients. This study performed a descriptive analysis of patient characteristics, percentage of SGAs prescribed, regimen doses of SGAs, average number of SGAs prescribed per patient, and pattern of antipsychotics prescribed.

Results
The most commonly used SGAs were risperidone 55%, followed by clozapine 38%, aripiprazole 3%, quetiapine 3%, and olanzapine 1%. Antipsychotics were generally prescribed in their recommended doses. Almost all SGAs were prescribed as polypharmacy, and the most common combination of SGAs were risperidone and clozapine.

Conclusions
This study highlighted that risperidone was the major choice for treatment in the outpatient setting. Polypharmacy is the most common pattern prescription of SGAs in the National Mental Hospital in Indonesia. New studies should focus on the analyses of polypharmacy prospectively, and the role of pharmacist in collaboration with other health professionals in the managing of schizophrenia therapy.
Visualising Ostia’s Processional Landscape Through a Multi-Layered Computational Approach: Case Study of the Cult of the Magna Mater
Authors: Crawford Katherine A. 
Published: December 2019

AbstractOstia, the ancient port of Rome, had a rich religious landscape. How processional rituals further contributed to this landscape, however, has seen little consideration. This is largely due to a lack of evidence that attests to the routes taken by processional rituals. The present study aims to address existing problems in studying processions by questioning what factors motivated processional movement routes. A novel computational approach that integrates GIS, urban network analysis, and agent-based modelling is introduced. This multi-layered approach is used to question how spectators served as attractors in the creation of a processional landscape using Ostia’s Campo della Magna Mater as a case study. The analysis of these results is subsequently used to gain new insight into how a greater processional landscape was created surrounding the sanctuary of the Magna Mater.
Die Vorlesung
Authors: Wenzl Thomas 
Published: December 2019

Zusammenfassung
Als ein sich an viele Studierende gleichzeitig richtendes und damit zu der Idee eines individualisierten akademischen Unterrichts in Spannung stehendes Lehrformat ist die Vorlesung vielfacher Kritik ausgesetzt. Vor diesem Hintergrund arbeitet der Beitrag eine Funktion der Vorlesung für die universitäre Lehre heraus, die diese nicht trotz, sondern gerade wegen ihres kollektiven Charakters erfüllt. Es wird argumentiert, dass die Vorlesung dem allgemeinen Interaktionssituationstypus der „Rede“ entspricht, für den in allen gesellschaftlichen Kontexten, in denen er angetroffen werden kann, kennzeichnend ist, dass er seine Dignität der Anwesenheit möglichst großer öffentlicher Zuhörerschaften verdankt. Vor allem durch eine Analogiebildung zu der Situation der religiösen Rede, also der Predigt, werden einige elementare bildungsbedeutsame Erfahrungen herausgearbeitet, die die Vorlesung als Lehrformat sowohl Studierenden als auch Lehrenden ermöglicht.
A note on the eigenvalue free intervals of some classes of signed threshold graphs
Authors: Anđelić Milica , Koledin Tamara , Stanić Zoran 
Published: December 2019

Abstract
We consider a particular class of signed threshold graphs and their eigenvalues. If Ġ is such a threshold graph and Q(Ġ ) is a quotient matrix that arises from the equitable partition of Ġ , then we use a sequence of elementary matrix operations to prove that the matrix Q(Ġ ) – xI (x ∈ ℝ) is row equivalent to a tridiagonal matrix whose determinant is, under certain conditions, of the constant sign. In this way we determine certain intervals in which Ġ has no eigenvalues.
Protection Against XY Gonadal Sex Reversal by a Variant Region on Mouse Chromosome 13
Authors: Livermore Catherine , Simon Michelle , Reeves Richard , Stévant Isabelle , Nef Serge , Pope Madeleine , Mallon Ann-Marie , Wells Sara , Warr Nick , Greenfield Andy 
Published: December 2019

Abstract
XY C57BL/6J (B6) mice harboring a Mus musculus domesticus-type Y chromosome (YPOS), known as B6.YPOS mice, commonly undergo gonadal sex reversal and develop as phenotypic females. In a minority of cases, B6.YPOS males are identified and a proportion of these are fertile. This phenotypic variability on a congenic B6 background has puzzled geneticists for decades. Recently, a B6.YPOS colony was shown to carry a non-B6-derived region of chromosome 11 that protected against B6.YPOS sex reversal. Here. we show that a B6.YPOS colony bred and archived at the MRC Harwell Institute lacks the chromosome 11 modifier but instead harbors an ∼37 Mb region containing non-B6-derived segments on chromosome 13. This region, which we call Mod13, protects against B6.YPOS sex reversal in a proportion of heterozygous animals through its positive and negative effects on gene expression during primary sex determination. We discuss Mod13’s influence on the testis determination process and its possible origin in light of sequence similarities to that region in other mouse genomes. Our data reveal that the B6.YPOS sex reversal phenomenon is genetically complex and the explanation of observed phenotypic variability is likely dependent on the breeding history of any local colony.
The Effect of Electronic Payment Systems on Financial Performance of Microfinance Banks in Niger State
Authors: Sakanko Musa Abdullahi , David Joseph 
Published: December 2019

This study employs the cross sectional survey research design and the descriptive and ordinary least square regressions to examine the impact of Electronic-Payment Systems on the financial performance of Microfinance Banks and Institutions in Niger state, Nigeria. The results of the analysis indicate the presence of e-payment systems in the bank, which enjoys impressive acceptability, due to its ease of use and convenience. In addition, ATM facility, Internet payment options, e-payment cards, and mobile banking platforms shows a significant positive impact on the financial performance of COE-Minna microfinance bank. In essence, the improvement and review of e-payment platforms’ security, so as to attract more users, coupled with the reduction of charges associated with the use of the platforms as well as sensitization of potential users were recommended.
Májátültetés Wilson-kóros betegekben, 1996–2017
Authors: Németh Dániel , Folhoffer Anikó , László Szilvia Bianka , Kóbori László , Görög Dénes , Fehérvári Imre , Fazakas János , Gerlei Zsuzsanna , Máthé Zoltán , Szalay Ferenc 
Published: December 2019

Absztrakt:
Bevezetés: A Wilson-kór a rézanyagcsere ritka, kezelés nélkül
fatális, öröklődő megbetegedése. Bár a diagnosztika és a kezelés jelentős
fejlődésen ment át az elmúlt években, számos beteg esetében ma is májátültetésre
van szükség. Célkitűzés: A vizsgálat célja a Magyarországon
Wilson-kór miatt májátültetésen átesett betegek adatainak összegyűjtése és
feldolgozása volt. Módszer: Retrospektív módon vizsgáltuk a
Semmelweis Egyetemen 1996 és 2017 között Wilson-kór miatt májátültetésen átesett
24 beteg adatait. A Wilson-kór diagnózisa minden esetben a nemzetközi, lipcsei
pontrendszeren alapult. A heveny májelégtelenség felállításához a King’s
College-kritériumrendszert használtuk. A májátültetések a Semmelweis Egyetem
Transzplantációs és Sebészeti Klinikáján történtek, első alkalommal 1996-ban.
Eredmények: Az átlagéletkor 26 év volt, a nő/férfi arány
13/11. 12 beteg heveny májelégtelenség miatt, 12 beteg dekompenzált cirrhosis
miatt esett át májátültetésen. Egy beteg krónikus rejekció miatt
retranszplantációra került. Három heveny májelégtelen beteg az Eurotransplant
segítségével kapott új májat. A várólistán eltöltött átlagos idő 3 nap volt a
heveny májelégtelen betegek, míg 320 nap a dekompenzált májbetegek esetében. Az
ötéves túlélés 66% volt, azonban a 2002 után transzplantáltak esetében 80%, ami
a tanulási folyamatot és a májátültetés elérhetőségének javulását jelezheti. A
diagnosztika nehézségei ellenére a betegek többségében (21/24 beteg) már a műtét
előtt ismert volt a Wilson-kór. Következtetések: Bár a
Wilson-kór diagnosztikája és kezelése jelentős fejlődésen ment át az elmúlt évek
során, ma is számos esetben van szükség májátültetésre. A betegek megfelelő
kiválasztása és a transzplantáció időzítése jelentősen javítja a betegek
túlélését. Orv Hetil. 2019; 160(51): 2021–2025.
A cukorbetegség és a daganatos thrombocytosis túlélésre gyakorolt hatásának vizsgálata emlőtumoros nőkben
Authors: Somogyi Anikó , Herold Magdolna , Lohinszky Júlia , Harsányi László , Herold Zoltán 
Published: December 2019

Absztrakt:
Bevezetés: Számos daganatban igazolták, hogy mind a
thrombocytosis, mind a 2-es típusú cukorbetegség negatívan befolyásolja a
tumoros betegek túlélését. A két tényező szerepét együttesen emlőtumorokban
eddig még nem vizsgálták. Célkitűzés: Vizsgálatunk célja a
Semmelweis Egyetem II. sz. Belgyógyászati Klinika, illetve az I. sz. Sebészeti
Klinika szakambulanciáin 2014−2017 között emlőtumor miatt kezelt
betegpopulációban a thrombocytosis és a 2-es típusú diabetes gyakoriságának és a
daganatos betegség kimenetelére gyakorolt önálló és együttes hatásának felmérése
volt. Vizsgáltuk az emlőtumor diagnózisakor a laboratóriumi és anamnesztikus
adatokat a cukorbeteg és nem cukorbeteg csoportokban, túléléselemzéssel a
thrombocytosis és/vagy a 2-es típusú cukorbetegség túlélést befolyásoló hatását.
Módszer: Retrospektív vizsgálatunkban 274, emlőtumoros
beteg adatait elemeztük. A betegeket legkésőbb 2018. 12. 31-ig, az utolsó
egyetemi megjelenésükig vagy haláluk bekövetkeztéig követtük.
Eredmények: Emelkedett thrombocytaszámokat (400 G/l
feletti) a betegek ~5%-ában figyeltünk meg. A betegek közel ötöde 2-es típusú
cukorbeteg volt (52 fő). A cukorbetegek szignifikánsan idősebbek voltak a tumor
felismerésekor (nem cukorbeteg: 56,8 ± 13,8 év, cukorbeteg: 67,8 ± 11,0 év,
p<0,0001). A nem cukorbetegeknél gyakoribb a tripla negatív (p = 0,0366),
illetve a T1-es stádiumú tumor (50%), míg cukorbetegekben a T2-es stádium a
leggyakoribb (51,9%). A túlélési modell alapján az emlőtumoros betegek rövidebb
túlélési idejét prognosztizálja, ha 2-es típusú cukorbetegségben is szenvednek
(p = 0,0032). Vizsgálatunkban a betegek túlélését a thrombocytosis nem
befolyásolta. Következtetés: A 2-es típusú cukorbetegekben az
emlőtumor diagnosztizálásakor súlyosabb klinikai stádium valószínűsíthető, és
rövidebb túlélés prognosztizálható. Javasoljuk, hogy a cukorbeteg nők
kontrollvizsgálata alkalmával a nők figyelmét fel kell hívni a mammográfiai
szűrővizsgálatok fontosságára, illetve 30 éves kor felett a diabetest
rizikótényezőnek kell tekinteni, és a betegek szűrővizsgálata legalább kétévente
javasolt. Orv Hetil. 2019; 160(51): 2012–2020.
Launching the Journal of International Child Neurology Association (JICNA)
Authors: Newton Charles R.J.C , Hameed Biju A 
Published: December 2019

The International Child Neurology Association has started a peer-reviewed child neurology journal, the Journal of International Child Neurology Association (JICNA). The Journal website at http://jicna.org is up and running, and journal has already been receiving submissions. We would like to thank the brave authors who have submitted their initial papers to JICNA. The papers will be deposited on the web, and is currently indexed in CrossRef, Google Scholar and Directory of Open Access Journals (DOAJ).All manuscripts submitted to JICNA will undergo full peer review and fast publication. JICNA implements a continuous publication workflow, from 2013 where full citation details are provided for all published articles from the first date of publications whilst maintaining the archives in a number of issues per volume. Under the current licence scholars, scientists, government officials, and the general public can view, download, print and redistribute any article without a subscription. At present JICNA does not charge any article processing and publication fees.In addition the content in JICNA will also be integrated into ICNApedia (http://icnapedia.org) the Child Neurology Knowledge Environment published by the International Child Neurology Association (ICNA). This would allow readers to access the interesting and useful material on this platform. We aim to get the Journal indexed in Medline within the year and also deposit in other repositories including PubMed Central. In addition there are robust arrangements in place to ensure permanent preservation of, and access to, all content published. But to achieve these goals, the journal needs to be in existence for more than a year and published at least thirty peer-reviewed papers.JICNA will only flourish if it receives papers to publish, and is read and referenced by child neurologists all over the world. We have started and now we look to the ICNA membership to contribute to this journal, and be involved in a new and exciting publication in child neurology helping to disseminate current research as widely as possible. Please start submitting your papers to JICNA via the website: http://jicna.org/index.php/journal/about/submissions#onlineSubmissionsYou will need to register as an author, and follow the author guidelines for submission. If you having any difficulties please contact either of us directly. We look forward to receiving your manuscripts.
Non-syndromic patients with infantile spasms and malformations of cortical development: absence of seizures in siblings
Authors: Tiwari Vijay N , Chugani Harry T , Kupsky William J , Huq AHM M 
Published: December 2019

Background: Parents of children with infantile spasms undergoing epilepsy surgery typically inquire about the risk of other children for a similar affliction. Here, we determined whether non-syndromic patients with infantile spasms and malformation of cortical development (MCD) have a family history of seizures, particularly in siblings.Patients and methods: We selected 29 children with intractable infantile/epileptic spasms who underwent surgery (mean age at surgery: 4.4±3.8 years; 12 males, 17 females; age range 0.8-14.9 years). A pathological diagnosis of MCD was confirmed in all the patients. Family (including parents, and siblings) history of seizures was acquired in all patients through neurology chart review/telephonic interview.Results: Pathological diagnosis of migration disorder (16) and cortical dysplasia (9) was made in these patients. Diagnosis of hemimegalencephaly, dysembryoplastic neuroepithelial tumor (DNET), lissencephaly type1 and porencephaly was also confirmed in 4 different patients. None of the siblings in any family (total number of siblings in the group = 30) were affected by infantile spasms or other types of seizures. The maternal aunt of one patient and mother of another patient had a history of childhood seizures for short durations.Conclusions: Our retrospective study showed that patients with infantile spasms with MCD who underwent resective surgery have low sibling recurrence risk for seizures. Our study suggests that de novo mutations and non-genetic or epigenetic factors are major causes of infantile spasms due to MCD.
Vitamin and Cofactor Responsive Encephalopathies and Seizures
Authors: Tein Ingrid 
Published: December 2019

Early diagnosis and treatment vitamin and/or cofactor responsive encephalopathies and seizures is critical for both seizure control and cerebral development and to prevent the kindling of intractable seizures with secondary brain injury. Recognition of these specific disorders is key to their management given their essential requirement for specific cofactors and their reduced responsiveness to standard anticonvulsant therapy. The overall goals of this review are; (1) To provide recognition of the clinical phenotypes of selected treatable metabolic etiologies of early-onset encephalopathies with seizures; (2) To highlight the appropriate diagnostic investigations for each, and (3) To outline the effective treatment strategies. Each condition will be described followed by an approach to vitamin-responsive infantile-onset seizure management. A list of vitamin/cofactor responsive neurological conditions is provided in Table 1.