bluuebunny/crossref_metadata_2025_split huggingface dataset:
Features of changes in refraction in children with congenital aniridia
Authors: Суханова Н.В. , Катаргина Л.А. , Васильева Т.А. , Марахонов А.В. , Зинченко Р.А. 
Published: December 2020

Снижение остроты зрения при врожденной аниридии связано с дефектом радужной оболочки и комплексом изменений разной степени выраженности других структур глаза (роговица, зрительный нерв, сетчатка и др.). Прогнозирование изменения рефракции - сложная проблема, так как имеются широкие вариации состояния структур и функций глаза с момента рождения и их динамики с возрастом, а также вариации, обусловленные как генетическими факторами, так и адекватностью лечебно-профилактических мероприятий, и приверженностью пациентов к коррекции. В представленном сообщении описано изменение рефракции у 57 детей от 2 месяцев до 7 лет жизни с РАХ6-ассоциированной врожденной аниридией.
Reduced vision acuity in congenital aniridia is associated with a defect in the iris and a complex of changes of varying degrees of severity in other eye structures (cornea, optic nerve, retina, etc.). Prediction of changes in refraction is a complex problem, since there are wide variations in the state of the structures and functions of the eye from birth and their dynamics with age, as well as variations due to both genetic factors and the adequacy of treatment and prophylactic measures as well as patient’s adherence to therapy. The article describes the changes in refraction in children aged from 0 to 7 years old with PAX6-associated congenital aniridia.
Clinical and genetic characteristics of chronic pancreatitis in patients under 20 years old
Authors: Литвинова М.М. , Хафизов К.Ф. , Никольская К.А. , Винокурова Л.В. , Дубцова Е.А. , Мацвай А.Д. , Ипатова М.Г. , Хавкин А.И. , Мухина Т.Ф. , Бордин Д.С. 
Published: December 2020

Хронический панкреатит (ХП) представляет собой актуальную проблему современной медицины. При проявлении ХП у детей заболевание протекает особенно тяжело и часто требует хирургического лечения. В России работ по выявлению генетических причин панкреатита крайне мало. Еще меньше данных о влиянии генетических факторов на риск развития панкреатита у детей. В настоящей работе с помощью технологии массового параллельного секвенирования проведено генотипирование 25 больных ХП с манифестацией заболевания до 20 лет. Секвенировалась кодирующая последовательность генов SPINK1 и PRSS1. В группе обследуемых выявлено 11 носителей мутаций анализируемых генов, что составляет 44% от общего числа больных. Установлен спектр мутаций и особенности клинического течения ХП у лиц моложе 20 лет в России. Выявление молекулярно-генетической причины ХП позволяет прогнозировать характер течения заболевания и проводить профилактику болезни у ближайших родственников больного.
Chronic pancreatitis (CP) is an urgent problem of modern medicine. If CP manifests in childhood, the course of the disease is particularly severe and often requires surgical treatment. In Russia there are few investigations of the genetic causes of pancreatitis. There is even less data on the influence of genetic factors on the pancreatitis development in children. In this study we performed genotyping of 25 CP patients with a clinical manifestation of the disease at the age under 20 years old. Genetic analysis was carried out by Next Generation Sequencing (NGS). All coding regions of the SPINK1 and PRSS1 genes were analyzed. Mutations of the mentioned genes were found in 11 patients (44%). The spectrum of mutations and the clinical course of CP in Russian individuals younger than 20 years old have been established. The identification of the molecular genetic cause of CP helps to predict the severity of the disease and to prevent the disease in the relatives of the patient.
System for computer diagnosis of hereditary diseases
Authors: Кобринский Б.А. , Благосклонов Н.А. , Демикова Н.С. 
Published: December 2020

В работе описаны принципы создания компьютерной консультативной системы поддержки принятия решений при диагностике наследственных заболеваний на долабораторном этапе. Прототип реализуется на примере клинических проявлений лизосомных болезней накопления. В основу системы положены литературные данные, которые сопровождаются оценками экспертов. Разрабатываемая интеллектуальная система формирует ограниченный дифференциально-диагностический ряд гипотез. Это обеспечивает помощь врачу-генетику в дифференциальной диагностике как при наличии у него предварительного диагноза, так и при отсутствии у него предположений о нозологии заболевания.
The paper describes the principles of creating a computer consultative decision support system for the diagnosis of hereditary diseases at the pre-laboratory stage. The prototype is implemented on the example of the clinical manifestations of lysosomal storage diseases. The system is based on literary data, which are accompanied by expert assessments. The developed intellectual system forms a limited differential diagnostic row of hypotheses. It provides assistance to the geneticist in differential diagnosis both in the presence of a preliminary diagnosis and in the absence of assumptions about the nosology of the disease.
Therapeutic Drug Monitoring: Performance of a FRET-Based Point-Of-Care Immunoassay for the Quantitation of Infliximab and Adalimumab in Blood
Authors: Ong Edgar , Huang Ruo , Kirkland Richard , Westin Stefan , Salbato Jared , Bray Kurt , Mimms Larry , Hale Michael , Day Valerie 
Published: December 2020

Two fast (<5 min), time-resolved fluorescence resonance energy transfer (FRET)-based immunoassays (Procise IFX™ and Procise ADL™) were developed for the quantitative detection of infliximab (IFX), adalimumab (ADL), and their respective biosimilars for use in therapeutic drug monitoring (TDM) using 20 µL of finger prick whole blood at the point-of-care or whole blood/serum in a central lab. Studies were performed to characterize analytical performance of the Procise IFX and the Procise ADL assays on the ProciseDx™ analyzer. The Procise IFX and Procise ADL assays both showed good analytical performance with respect to sensitivity, specificity, linearity, and precision suitable for routine clinical use as well as excellent correlation to current commercial ELISA IFX and ADL measurement methods. Results indicated that the Procise IFX and Procise ADL assays are sensitive, specific, and precise yielding results in less than 5 minutes from either whole blood or serum. This indicates the Procise IFX and Procise ADL assays are useful for obtaining fast and accurate IFX or ADL quantitation, thus avoiding delays inherent to current methods and enabling immediate drug level dosing decisions to be made during a single patient visit.
ANALISIS PENGARUH TOTAL SERVICE QUALITY MANAGEMENT TERHADAP KEPUASAN PELANGGAN JASA TRANSPORTASI
Authors: Qomari Ika Nurul , Rahman Afrizal . 
Published: December 2020

Abstract This research was conducted to analyze the influence of Total Service Quality Management to the customers satisfaction (the customers in this research were the user servicing Persada Tour & Travel of Yogyakarta agency) by using 5 dimensions of TSQM: physical quality dimension, supporting physical Quality, company/institution quality, technical Quality dimension, and interactive quality dimension. The method used for data collecting was survey method by giving question naires to the respondents. The technique used to take the samples of the research was purposive sampling. In this research validity and Reliability tests were conducted to ensure the validity and reliability of the research instruments. Data Analyzed used in the research were multiple linear regression, t test, and F test. The result of the research shows that there is an influence of Total Service Quality Management to the customers satisfaction on the dimensions of physical quality, supporting physical quality", company/institution quality, technical quality, and interactive quality dimension forward the business class train passengers, both partially and simultaneously of all dimension. The most influential dimensions to the Customers satisfaction is the company/institution quality'. Keyword : Service Quality, Satisfaction
Strategi Manajemen Sebagai Faktor Mitigasi Dalam Penerimaan Opini Audit Studi Empirik pada Perusahaan Manufaktur di Indonesia
Authors: Setyowati Widhy 
Published: December 2020

This research aims to provide emprical evidence upon the research questions proposed by conducting measurement of the hypothesis on the influence of the management strategy as mitigation factor in predicting the acceptance of GCO that involves financial based strategy such as sale of common stock strategy, issuing new debt restructure, and sale of fixed asset. Whereas, non financial strategy that is expansionist and oriented to external market that will be studied as mitigation factor includes cooperative strategy or long term contract strategy and new product development strategy or expansion of new market segment. The result show that the sale of common stock strategy and issuance of new debt or restructuring of debt strategy are the mitigation factors in acceptance of going concern opinion, whereas reducing cost strategy are perceived as additional going concern risk factors and increase the likelihood to receive a going concern opinion. Other strategies such as disposed fixed asset strategy, cooperation/long-term contracted streategy and development new product/expanding new market segments can not be used to predict the acceptance of going concern opinion.Keywords : going concern opinion, financial distress, management strategy, mitigation factor
PENGARUH GAYA KEPEMIMPINAN TRANSFORMASIONAL DAN BUDAYA ORGANISASI TERHADAP KINERJA PEGAWAI DENGAN KOMITMEN ORGANISASI SEBAGAI VARIABEL INTERVENING (Studi pada PNS di Kecamatan Watukumpul Kabupaten Pemalang)
Authors: Mubarak Ahmad , Darmanto Susetyo 
Published: December 2020

This study aimed to determine the effect of transformational leadership style on performance and organizational commitment as an intervening variable, the influence of organizational culture on employee performance and organizational commitment as an intervening variable, determine the effect of transformational leadership style directly to employee performance, and determine the influence of organizational culture directly to the employee performance. The population in this study were all employees of the Watukumpul districtl. By using the census method, all employees amounted to 140 people were carried out as the sample. Analysis data were analyzed using path analysis. Based on the research results it could be concluded that there was significantly and positive effect of transformational leadership style and organizational culture. Transformational leadership style and organizational culture also had significantly and positive effect on Organizational commitment. And finally there was significantly and positive effect of organiztional commitment.The research also showed that Organizational commitment had a mediating role between transformational leadership style, Organizational culture and employee performance. Keyword: Transformational Leadership Style, Cultural Organization,Organizational Commitment, Employee Performance
MENGUJI KESYARIAHAN AKAD WADIAH PADA PRODUK BANK SYARIAH
Authors: Murdadi Bambang 
Published: December 2020

Salah satu akad dalam produk Perbankan Syariah adalah akad Wadiah. Pengertian Akad Wadiah adalah perjanjian penitipan dana antara pemilik dana dengan pihak penerima titipan yang dipercaya untuk menjaga dana tersebut; (PBI No.2/9/2000). Produk Perbankan Syariah dengan akad Wadiah antara lain dalam produk Giro Wadiah, Tabungan Wadiah, Sertifikat Wadiah Bank Indonesia. Sesuai dengan Fatwa dari Dewan Syariah Nasional bahwa produk giro wadiah secara umum memiliki kriteria 1. Bersifat titipan 2. Titipan bisa diambil kapan saja (on call) 3.Tidak ada imbalan yang disyaratkan, kecuali dalam bentuk pemberian (athaya) yang bersifat sukarela dari pihak bank. Adapun dasar syariahnya antara lain dalam Firman Allah QS Annnisa (4):29. Hai orang yang beriman ! janganlah kalian saling memakan (mengambil) harta sesamamu dengan jalan yang batil, kecuali dengan jalan perniagaan yang berlaku dengan sukarela diantaramu. Di dalam praktek perbankan di lapangan, beleid (point) yang menyatakan “tidak ada imbalan yang dipersyaratkan” ataupun tidak ada imbalan yang dijanjikan dimuka apakah benar-benar telah diterapkan secara murni dan syar’ie?Perlu dikaji lebih mendalam. Baik tinjauan dari sisi legal formal (ketentuan yang ada) diluar fatwa Dewan Syariah Nasional maupun dalam praktek bisnis perbankan di lapangan. Dari hasil pengamatan dan diskusi, terkesan masih bersifat ambigu (abu-abu) ditengah praktek dunia bisnis perbankan yang penuh dengan persaingan yang sangat ketat.Kata kunci : akad wadiah, titipan, imbalan sukarela.
EFEK KONVERGENSI KERANGKA DASAR IFRS (IAS 12 REVISI) TERHADAP PSAK 46
Authors: Kristiana Ida 
Published: December 2020

This purpose of this study to examine the presence or absence of securities caused by the convergence of IFRS to Statement of Accounting Standards of Income Tax (PSAK 46), by simulating the financial statements of PT. Garuda Indonesia Airlines (GIA) and PT. Telkom Indonesia. This study also looks at the differences between financial reports that are not convergent compared with financial reportsthat are already convergent with IFRS This study used a comparison method between the statements presented in IFRS with the statements presented in PSAK 46. The unit of analysis in this study is the International Financial ReportingStandard (IFRS) and Statement of Financial Accounting Standards on income tax accounting as well as books and articles related to both. The results of this study indicate that the convergence of the IFRS framework to PSAK 46 has a significant impact on the financial statements, especially on capital budgeting, because the tax will affect the calculation of cash flow. Besides this convergence also has an impact on the tax calculation in the financialstatementsKeywords: IFRS, PSAK, Financial Statement, Convergence
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI ADOPSI E COMMERCE DAN PENGARUHNYA TERHADAP KINERJA UMKM (STUDI KASUS UMKM DI WILAYAH KOTA SEMARANG)
Authors: Noviani  Hanum Ayu , Sinarasri Andwiani 
Published: December 2020

E-Commerce sering disebut sebagai salah satu pendorong pertumbuhan ekonomi di Indonesia.)Besarnya potensi e-commerce tidak lepas dari perkembangan pengguna internet di Indonesia. Pada tahun 2015, pengguna internet di Indonesia mencapai 93,4 juta jiwa, meningkat cukup pesat jika dibandingkan dengan88,1 juta jiwa pada 2014. Potensi e-commerce terlihat dari angka 77% dari penggunaan internet digunakanuntuk mencari informasi produk dan berbelanja online, pelanggan online shop yang mencapai 8,7 juta orang,dan nilai transaksi yang diprediksi mencapai US$ 4,89 Miliar pada tahun 2016. Usaha Kecil Mikro dan Menengah (UMKM) di Indonesia memiliki peranan penting dalam perekonomian nasional. UMKMdituntut untuk melakukan perubahan dan inovasi untuk meningkatkan daya saing, salah satunya adalah denganmemanfaatkan e commerce.Tujuan penelitian ini adalah untuk mengetahui dan menganalisis pengaruh faktor teknologi,organisasional, lingkungan dan individual terhadap adopsi e commerce serta menganalisis pengaruh adopsi ecommerce terhadap kinerja UMKM. Metode pengumpulan data dilakukan melalui penyebaran kuesioner danwawancara pada 100 UMKM di Kota Semarang. Metode analisis dalam penelitian ini menggunakanperhitungan regresi berganda dengan menggunakan SPSS 20.0 untuk melihat pengaruh tidak langsung antarasatu variable dengan variable lainnya.Hasil uji t dalam penelitian ini menunjukkan bahwa faktor teknologi dan faktor individual secaraparsial berpengaruh positif dan signifikan terhadap adopsi e commerce. Sebaliknya faktor organisasionalsecara parsial berpengaruh negatif dan tidak signifikan terhadap adopsi e commerce dan faktor lingkungansecara parsial berpengaruh positif dan tidak signifikan terhadap adopsi e commerce pada UMKM di KotaSemarang. Hasil uji F menunjukkan bahwa secara simultan faktor kesiapan teknologi, organisasional,lingkungan dan individual berpengaruh secara bersama-sama terhadap adopsi e commerce pada UMKM di KotaSemarang.
PENGEMBANGAN E-BOOK DENGAN SOFTWARE FLIPBOOKMAKER UNTUK PEMBELAJARAN MATA KULIAH AKUNTANSI KEUANGAN DI STEKOM SEMARANG
Authors: Kholifah Siti 
Published: December 2020

Tujuan penelitian ini adalah untuk mengembangkan produk e-book untuk pembelajaran matakuliah akuntansi keuangan yang valid. Penelitian ini merupakan penelitian Research and Development.Penelitian pengembangan ini menggunakan modifikasi model 4D menjadi 3D dengan tahap define(pendefinisian), design (perencanaan), dan development (pengembangan). E-book dengan softwareflopbookmaker terlebih dahulu dilakukan uji validasi oleh ahli media, ahli materi dan juga angkettanggapan mahasiswa. Diperoleh rata-rata penilaian validasi ahli materi 85,2%, validasi ahli media89,2%, penilaian tanggapan mahasiswa 85,2%, Jadi media E-book layak digunakan dengan kategori sangatbaik.
PENGARUH TINGKAT PENDIDIKAN, PENDAPATAN, GENDER, DAN TEMPAT TINGGAL TERHADAP AKUNTANSI RUMAH TANGGA
Authors: Rudi Yulianto Ahmad , Syahputra Bekti 
Published: December 2020

Berdasarkan data dari Kementerian Agama di tahun 2014, 1 dari 10 pernikahan di Indonesia berakhir dengan perceraian karena faktor ekonomi. Sedangkan hasil penelitian Vidisha (2016) menyimpulkan praktik akuntansi rumah tangga belum mendapat perhatian besar di kalangan ilmuwan akuntansi, Vidisha juga berpendapat masih sedikit yang mengetahui bagaimana akuntansi digunakan di rumah tangga.Atas dasar penelitian terdahulu peneliti memberi judul pengaruh tingkat pendidikan, pendapatan, gender, dantempat tinggal terhadap akuntansi rumah tangga. Tujuan penelitian mengeksplorasipenelitian-penelitian terdahulu yang terkait faktor-faktor yang membahas tentang akuntansi rumah tangga dan menerangkan beberapa variabel yang hampir sama,diantaranya tentang pengaruh tingkat pendidikan, tingkat pendapatan, gender, dan tempat tinggal terhadappenerapan akuntansi rumah tangga.Populasi penelitian di kampus Unissula Semarang, dengan sampel sebanyak 42 orang responden. Jenis penelitian menggunakan explanatory research, pengumpulan datamenggunakan kuesioner yang diuji validitas dan reliabilitasnya. Metode analisis data menggunakan uji regresilinier berganda, berserta uji hipotesisnya yang sebelumnya diuji dengan uji asumsi klasik (normalitas,multikolinearitas dan heterokedastisitas).Hasil pengolahan data diperoleh, tingkat pendidikan, tingkat pendapatan dan genderberpengaruh tehadap akuntansi rumah tangga, sedangkan variabel tempat tinggal tidak berpengaruh tehadapakuntansi rumah tangga.
Indicators of humoral immunity in patients with COVID-19
Authors: Amvrosieva T. V. , Paklonskaya N. V. , Belskaya I. V. , Bohush Z. F. , Kazinetz O. N. , Anisko L. A. , Rogacheva T. A. , Kоltunova Yu. B. 
Published: December 2020

В работе проанализированы данные о частоте обнаружения вирусспецифических антител (АТ) у пациентов с COVID-19, сроках их появления и кинетике сероконверсии. Так, суммарные АТ к коронавирусу SARS-CoV-2 были обнаружены у 55,7 % пациентов, а IgG ‒ у 74,7 % лиц с лабораторно подтвержденной инфекцией COVID-19. Частота их выявления была достоверно выше, чем в других группах обследованных. В течение первых 6 сут кинетика сероконверсии характеризовалась появлением суммарных АТ и IgG у 10,5 и 5,3 % пациентов c COVID-19 соответственно. У большинства заболевших (71,4 %) сероконверсию IgM и IgG регистрировали в период с 7-х по 11-е сутки, а к 22-м суткам суммарные АТ и IgG были обнаружены у 100 % пациентов. Представленные в работе результаты дополняют накопленные в разных странах мира данные, касающиеся формирования гуморального иммунного ответа при COVID-19.
PERSEPSI SISWA TERHADAP PEMANFAATAN MEDIA KAHOOT DALAM PEMBELAJARAN BAHASA INDONESIA
Authors: Perdana Indra , Saragi Rinda Eria Solina , Aribowo Eric Kunto 
Published: December 2020

Learning media is one of the key factors affecting the success of the learning process. Selecting and using appropriate and attractive media will have a positive impact on student learning success. Unfortunately, the use of educational me-dia, particularly those based on information and communi-cation technology (ICT) for Indonesian language learning, is still not widely practiced in Palangka Raya Christian Mid-dle School. The aim of this study is to identify students' per-ceptions of Indonesian language lessons using Kahoot media (a game-based learning application). Twenty five respond-ents selected for the purpose of sampling, a questionnaire was provided via google form. Data were analyzed using an independent sample t-test to determine Kahoot media's level of usefulness in Indonesian language learning. Integrating the use of ICT, especially smartphones, to learn Indonesian in the classroom can add positive energy to students, which in turn increases student motivation, student engagement and academic success. AbstrakMedia pembelajaran menjadi salah satu faktor krusial yang berpengaruh terhadap keberhasilan proses pem-belajaran. Pemilihan dan pemanfaatan media yang te-pat dan menarik akan berdampak positif terhadap keberhasilan belajar siswa. Sayangnya, pemanfaatan media pembelajaran terutama yang berbasis teknologi informasi dan komunikasi (TIK) untuk pembelajaran Bahasa Indonesia masih belum banyak dilakukan di SMP Kristen Palangka Raya. Penelitian ini bertujuan untuk mengetahui persepsi siswa terhadap pelajaran Bahasa Indonesia yang memanfaatkan media Kahoot (sebuah aplikasi game-based learning). Dengan 25 re-sponden yang dipilih secara pusposive sampling, diberi-kan angket melalui google form. Data dianalisis dengan independent sample t-test guna mengetahui tingkat kebermanfaatan media Kahoot dalam proses pembelaja-ran Bahasa Indonesia. Hasil penelitian menunjukkan bahwa hampir semua siswa memiliki persepsi yang baik (48% Sangat Baik; 44% Baik) terhadap pemanfaatan media Kahoot dalam pembelajaran Bahasa Indonesia. Pengintegrasian pemanfaatan TIK khususnya smartphone di dalam pembelajaran bahasa Indonesia di kelas dapat menambah energi positif siswa yang pada akhirnya meningkatkan motivasi, keterli-batan/keaktifan, dan keberhasilan akademik siswa.
Design features of coal mines ventilation using a room-and-pillar development system
Authors: Kobylkin Sergey , Kharisov Alexander 
Published: December 2020

The safety of mining operations in coal mines for aerological factors depends on the quality of accepted and implemented ventilation design solutions. The current “Design Manual of coal mine ventilation” do not take into account the features of room-and-pillar development systems used in Russia. This increases the risk of explosions, fires, and gassing.
The detailed study of foreign experience in designing ventilation for the considered development systems e of coal deposits allowed to formulate recommendations on the ventilation scheme organization for coal mines using a room-and-pillar development system and the procedure for ventilation during multi-entry gateroad development.
Observations have shown that the use of the existing Russian procedure for airing mining sites with a room-and-pillar development system complicates the emergency rescue operations conduct. Low speeds and multidirectional air movement, difficult heat outflow, and the abandonment of coal pillars increase the risk of occurrence and late detection of endogenous fire.
The results of numerical modeling have shown that the installation (parallel to the drifts) of ventilation structures in inter-chamber pillars will increase the reliability of ventilation by transferring the ventilation scheme from a complex diagonal to a complex parallel. It will also reduce the amount of air required for the mine site and the total aerodynamic drag.
The research made it possible to formulate requirements for the design procedure for coal mines ventilation using a room-and-pillar development system, which consist in the order of working out blocks in the panel, and also the additional use of ventilation structures (light brattice clothes or blowing line brattice).