bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complementary and alternative medicine is positively associated with religiousness/spirituality
Authors: Heller Tabitha , Kloos Christof , Mueller Nicolle , Roemelt Josef , Keinki Christian , Wolf Gunter , Mueller Ulrich Alfons , Huebner Jutta 
Published: July 2020

Abstract

Background
Complementary and alternative medicine (CAM) is used often by patients with different diseases. While some authors subsume religiousness and spirituality to CAM, others do not. The objective of the present study was to assess the prevalence and types of CAM usage as well as the participants' spirituality/religiousness in an outpatient department for endocrinology and metabolic diseases.

Methods
All individuals visiting the outpatient department at a German university hospital from April to June 2009 were offered a standardized questionnaire on the use of dietary supplements and alternative therapies as well as their religiousness/spirituality. Demographic and clinical data of 428 respondents were taken from the electronic health record.

Results
Of the respondents, 16.4% (n = 66) classified themselves to be religious/spiritual and 67.9% (n = 273) as not religious/spiritual. Women were more religious/spiritual than men (p = 0.02). 41.4% of the respondents used supplements and 27.4% additional therapies. The use of supplements and additional therapies was more frequent in people with higher religiousness/spirituality (p = 0.005 and p = 0.01,resp.) but there were no associations between religiousness/spirituality and the number of consultations, costs for drugs, appraisal of the physicians treatment methods, the perceived effectiveness of prescribed drugs, fear of late complications or of side effects.

Conclusions
A higher religiousness/spirituality is associated with a more frequent use of supplements or additional therapies in individuals with endocrinopathies or metabolic diseases. As CAM has been shown to be associated with worse outcome, addressing religiousness/spirituality which stresses the responsibility of the person for his life might offer an additional resource and should be further studied.
The first 10 years of the international coordination network for standards in systems and synthetic biology (COMBINE)
Authors: Waltemath Dagmar , Golebiewski Martin , Blinov Michael L , Gleeson Padraig , Hermjakob Henning , Hucka Michael , Inau Esther Thea , Keating Sarah M , König Matthias , Krebs Olga , Malik-Sheriff Rahuman S , Nickerson David , Oberortner Ernst , Sauro Herbert M , Schreiber Falk , Smith Lucian , Stefan Melanie I , Wittig Ulrike , Myers Chris J 
Published: July 2020

Abstract
This paper presents a report on outcomes of the 10th Computational Modeling in Biology Network (COMBINE) meeting that was held in Heidelberg, Germany, in July of 2019. The annual event brings together researchers, biocurators and software engineers to present recent results and discuss future work in the area of standards for systems and synthetic biology. The COMBINE initiative coordinates the development of various community standards and formats for computational models in the life sciences. Over the past 10 years, COMBINE has brought together standard communities that have further developed and harmonized their standards for better interoperability of models and data. COMBINE 2019 was co-located with a stakeholder workshop of the European EU-STANDS4PM initiative that aims at harmonized data and model standardization for in silico models in the field of personalized medicine, as well as with the FAIRDOM PALs meeting to discuss findable, accessible, interoperable and reusable (FAIR) data sharing. This report briefly describes the work discussed in invited and contributed talks as well as during breakout sessions. It also highlights recent advancements in data, model, and annotation standardization efforts. Finally, this report concludes with some challenges and opportunities that this community will face during the next 10 years.
Identification of Biomarker on Biological and Gene Expression data using Fuzzy Preference Based Rough Set
Authors: Begum Shemim , Sarkar Ram , Chakraborty Debasis , Maulik Ujjwal 
Published: July 2020

AbstractCancer is fast becoming an alarming cause of human death. However, it has been reported that if the disease is detected at an early stage, diagnosed, treated appropriately, the patient has better chances of survival long life. Machine learning technique with feature-selection contributes greatly to the detecting of cancer, because an efficient feature-selection method can remove redundant features. In this paper, a Fuzzy Preference-Based Rough Set (FPRS) blended with Support Vector Machine (SVM) has been applied in order to predict cancer biomarkers for biological and gene expression datasets. Biomarkers are determined by deploying three models of FPRS, namely, Fuzzy Upward Consistency (FUC), Fuzzy Downward Consistency (FLC), and Fuzzy Global Consistency (FGC). The efficiency of the three models with SVM on five datasets is exhibited, and the biomarkers that have been identified from FUC models have been reported.
Face Recognition in Complex Unconstrained Environment with An Enhanced WWN Algorithm
Authors: Wang Dongshu , Wang Heshan , Sun Jiwen , Xin Jianbin , Luo Yong 
Published: July 2020

Abstract
Face recognition is one of the core and challenging issues in computer vision field. Compared to computer vision, human visual system can identify a target from complex backgrounds quickly and accurately. This paper proposes a new network model deriving from Where-What Networks (WWNs), which can approximately simulate the information processing pathways (i.e., dorsal pathway and ventral pathway) of human visual cortex and recognize different types of faces with different locations and sizes in complex background. To enhance the recognition performance, synapse maintenance mechanism and neuron regenesis mechanism are both introduced. Synapse maintenance is used to reduce the background interference while neuron regenesis mechanism is introduced to regulate the neuron resource dynamically to improve the network usage efficiency. Experiments have been conducted on human face images of 5 types, 11 sizes, and 225 locations in complex backgrounds. Experiment results demonstrate that the proposed WWN model can basically learn three concepts (type, location and size) simultaneously. The experiment results also show the advantages of the enhanced WWN-7 model for face recognition in comparison with several existing methods.
Association of sleep characteristics with adiposity markers in children
Authors: Herttrich Theresa , Daxer Johann , Hiemisch Andreas , Kluge Jens , Merkenschlager Andreas , Kratzsch Jürgen , Scheuermann Kathrin , Jenni Oskar G. , Körner Antje , Kiess Wieland , Quante Mirja 
Published: July 2020

Abstract

Background
Accumulating evidence suggests a relationship between sleep alterations and overweight/obesity in children. Our aim was to investigate the association of sleep measures other than obstructive sleep apnea or sleep duration with overweight/obesity and metabolic function in children.

Methods
We conducted a prospective cohort study in school- aged children (aged 5 to 8 years, prepubertal, and 12 to 15 years, pubertal) with overweight/obesity and normal-weight children. All children underwent a standardized in-laboratory polysomnography followed by a fasting blood assessment for glucose and metabolic testing. Subjective sleep measures were investigated by a 7-day sleep diary and questionnaire. We analyzed prepubertal and pubertal groups separately using logistic regression and partial correlation analyses.

Results
A total of 151 participants were analyzed. Overweight/obese children had significantly higher odds for arousal index (prepubertal children: 1.28, Confidence interval (CI): 1.06, 1.67; pubertal children: 1.65, CI: 1.19, 2.29) than normal-weight children, independent of age and gender. In prepubertal children, arousal-index was positively associated with C-peptide (r=0.30, p=0.01), whereas Minimum O2 saturation was negatively associated with triglycerides (r=−0.34, p=0.005), adjusting for age and sex. However, associations were attenuated by further adjustment for body mass index standard deviation scores (BMI-SDS). In pubertal children, higher level of apnea-hypopnea-index and pCO2 predicted increased lipoprotein (a) levels (r=0.35, p=0.03 and r=0.40, p=0.01, respectively), independent of age, sex, and BMI-SDS. A negative association was found between pCO2 and high-density lipoprotein (HDL)-cholesterol (r=−0.40, p=0.01).

Conclusions
Overall, we report that sleep quality as measured by arousal index may be compromised by overweight and obesity in children and warrants attention in future intervention programs.
Definition and early diagnosis of metabolic syndrome in children
Authors: Christian Flemming Gunter Matthias , Bussler Sarah , Körner Antje , Kiess Wieland 
Published: July 2020

Abstract
With this review, we aim to focus the attention on some established as well as new concepts for the metabolic syndrome (MetS) in children and adolescents spanning from definition to recommendations for the diagnostic approach. Even though there is no international commonly used definition of the metabolic syndrome in children and adolescents, all definitions include obesity as precondition for the development of MetS even in children. Obesity is one of the major cardiometabolic risk factors and it is strongly linked to other metabolic diseases like hyperlipidemia, hyperinsulinemia as well as hypertension. The metabolic syndrome is commonly known as a constellation of the mentioned morbidities. Pediatricians and researchers agree that early diagnosis and early interventions of the MetS are important to improve the prevention of cardiovascular disease and type 2 diabetes in adulthood. However, this requires appropriate screening tools for children and adolescents at risk for the MetS and its comorbidities. Due to controversies regarding the definition of MetS and the lack of consensus thresholds for the single components in children and adolescents, there is no internationally accepted diagnostic pathway for MetS available. However, several consensus statements and national guidelines for the assessment of obesity and its comorbidities in children and adolescents are available. Obesity seems to be the driving factor for the development of the other risk factors of MetS. In order to avoid conflicts concerning the definition of overweight and obesity, we recommend using the WHO definition of overweight (one standard deviation body mass index for age and sex and obesity; two standard deviations body mass index for age and sex) in children and adolescents.
Menstrual cycle, reproductive function, body mass index, and metabolic profiles of women with former central precocious puberty: 10–20-year longitudinal cohort study in southern Thailand
Authors: Satitpatanapan Pitchaya , Jaruratanasirikul Somchit , Sriplung Hutcha 
Published: July 2020

Abstract

Background
In 2011, we described 64 girls diagnosed with central precocious puberty (CPP) during 1995–2009. In 2019, the former CPP patients were 16–30 years of age and had been followed-up for 6–20 years after cessation of gonadotropin-releasing hormone analog (GnRHa) treatment.

Objectives
To determine the menstrual cycle, reproductive function, and long-term sequelae of the former GnRHa-treated and untreated CPP patients.

Methods
Sixty-seven former CPP women diagnosed during January 1995 to December 2010 were evaluated in 2019 for current menstrual cycle and pregnancy rate and for general health status, weight, height, blood pressure, and metabolic profiles of glucose, lipids, insulin, and testosterone.

Results
In 2019, the former CPP women averaged 20.7 ± 2.7 years of age (range: 16.5–30). Eighty-three percent had a regular menstrual cycle. Of the 14 married women, six (43%) were fertile with 1–2 children. The untreated women had a significantly higher rate of obesity (BMI >25 kg/m2) than the GnRHa-treated women (72.1% vs. 36.6%, p < 0.01). Two women (3%) had polycystic ovary syndrome (PCOS). Fasting plasma glucose, serum high-density lipoprotein cholesterol (HDL-C), and testosterone levels were normal and similar between the GnRHa-treated and untreated participants. The serum insulin, cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-C), and homeostasis model assessment-insulin resistance (HOMA-IR) levels were higher in the untreated group than the GnRHa-treated group, but without significant differences.

Conclusions
At a 10–20-year follow-up, our former CPP patients had regular menstruation, normal reproductive function, and normal metabolic outcomes. The low prevalence of PCOS of 3% suggests that CPP is not a risk factor for PCOS, at least during early adulthood.
Influence of newborn head circumference and birth weight on the delivery mode of primipara: what is more important?
Authors: Passerini Karolina , Kurmanavicius Juozas , Burkhardt Tilo , Balsyte Dalia 
Published: July 2020

AbstractObjectivesAim of the study was to analyze the impact of head circumference (HC) and birth weight (BW) on the delivery mode and delivery outcomes.MethodsStudy population consisted of pregnancy, delivery and newborn data from 1,762 women, who delivered between 2004 and 2016 at University Hospital of Zurich (UHZ). Odds ratio (OR) with 95% confidence intervals (CI) were calculated for mode of delivery. Newborns were sorted into four groups according HC or BW. To evaluate the association between HC and delivery outcome, a descriptive analysis was performed. In addition reference charts of newborn HC at term were constructed.ResultsOR for instrumental delivery (ID) was 2.37 (CI 95%, 1.63–3.46), for C-Section (CS) 3.74 (CI 95%, 1.49–9.37) when HC >36 cm. OR for ID was 1.59 (CI 95%, 1.02–2.50), for CS 3.18 (CI 95% 1.08–9.350) when BW was >4,000 g. OR for ID was 2.15 (95% CI, 1.69–2.73), for CS 1.93 (95% CI, 0.89–4.18) when HC ≥36 cm and BW <4000 g. OR for ID was 2.23 (95% CI, 1.35–3.67), for CS 4.39 (95% CI, 1.48–12.99) when HC ≥36 cm and BW ≥4,000 g. HC ≥36 cm was defined as large in our study. Mothers with higher age and body mass index delivered babies with larger HC (p<0.05). Blood loss and duration of expulsion period and BW was associated with larger HC (p<0.05).ConclusionsThe rate of ID and CS increased in case of a larger HC and greater BW. However, the main prognostic factor for ID was size of HC: ≥36 cm, but not macrosomia.
Reference ranges for the fetal mitral, tricuspid, and interventricular septum annular plane systolic excursions (mitral annular plane systolic excursion, tricuspid annular plane systolic excursion, and septum annular plane systolic excursion) between 20 and 36 + 6 weeks of gestation
Authors: Peixoto Alberto Borges , Bravo-valenzuela Nathalie Jeanne , Martins Wellington P. , Tonni Gabriele , Mattar Rosiane , Moron Antonio Fernandes , Pares David Baptista , Araujo Júnior Edward 
Published: July 2020

Abstract

Objectives
This study aimed to establish reference ranges for fetal mitral, tricuspid, and interventricular septum annular plane systolic excursions (MAPSE, TAPSE, and SAPSE) in normal pregnant women between 20 and 36 + 6 weeks of gestation.

Methods
This prospective and cross-sectional study included 360 low-risk singleton pregnancies between 20 and 36 + 6 weeks of gestation. MAPSE, TAPSE, and SAPSE were measured by M-mode in real time in an apical or basal four-chamber view through placing the cursor at the atrioventricular junction, marked by the valve rings at the tricuspid, mitral, and basal septum, respectively. A regression analysis was done to determine the appropriate polynomial equation model for both measurements and standard deviation (SD) values in relation to gestational age (GA). The intra- and inter-observer reproducibility was evaluated using the concordance correlation coefficient (CCC) and limits of agreement (LoA).

Results
There was a significant positive correlation between MAPSE (r=0.705, p<0.0001), TAPSE (r=0.804, p<0.0001), and SAPSE (r=0.690, p<0.0001) and GA. The mean of each parameter ranged as follows: 2.87–5.56 mm, MAPSE; 3.98–8.07 mm, TAPSE; and 2.34–4.21 mm, SAPSE. Poor/moderate intra- and inter-observer reliability (CCC between 0.70 and 0.90) and poor/moderate agreement of all the tested parameters were evaluated (LoA between 10 and 50%).

Conclusions
Reference values were established for the fetal MAPSE, TAPSE, and SAPSE between 20 and 36 + 6 weeks of gestation in low-risk pregnant women. These parameters showed poor/moderate reproducibility.
Prediction of extubation success using the diaphragmatic electromyograph results in ventilated neonates
Authors: Hunt Katie A. , Hunt Ian , Ali Kamal , Dassios Theodore , Greenough Anne 
Published: July 2020

Abstract

Objectives
Extubation failure is common in infants and associated with complications.

Methods
A prospective study was undertaken of preterm and term born infants. Diaphragm electromyogram (EMG) was measured transcutaneously for 15–60 min prior to extubation. The EMG results were related to tidal volume (Tve) to calculate the neuroventilatory efficiency (NVE). Receiver operating characteristic curves (ROC) were constructed and areas under the ROCs (AUROC) calculated.

Results
Seventy-two infants, median gestational age 28 (range 23–42) weeks were included; 15 (21%) failed extubation. Infants successfully extubated were more mature at birth (p=0.001), of greater corrected gestational age (CGA) at extubation (p<0.001) and heavier birth weight (p=0.005) than those who failed extubation. The amplitude and area under the curve of the diaphragm EMG were not significantly different between those who were and were not successfully extubated. Those successfully extubated required a significantly lower inspired oxygen and had higher expiratory tidal volumes (Tve) and NVE. The CGA and Tve had AUROCs of 0.83. A CGA of >29.6 weeks had the highest combined sensitivity (86%) and specificity (80%) in predicting extubation success.

Conclusions
Although NVE differed significantly between those who did and did not successfully extubate, CGA was the best predictor of extubation success.
COVID-19 does not stop obstetrics: what we need to change to go on safely birthing. The experience of a University Obstetrics and Gynecology Department in Milan
Authors: Alfieri Nikita , Manodoro Stefano , Marconi Anna Maria 
Published: July 2020

Abstract
Since SARS-COV-2 appeared in Wuhan City, China and rapidly spread throughout Europe, a real revolution occurred in the daily routine and in the organization of the entire health system. While non-urgent clinical services have been reduced as far as possible, all kind of specialists turned into COVID-19 specialists. Obstetric assistance cannot be suspended and, at the same time, safety must be guaranteed. In addition, as COVID-19 positive pregnant patients require additional care, some of the clinical habits need to be changed to face emerging needs for a vulnerable but unstoppable kind of patients. We report the management set up in an Obstetrics and Gynecology Unit during the COVID-19 era in a University Hospital in Milan, Italy.
First record of Sanborn’s bonneted bat, Eumops hansae (Molossidae), in Colombia
Authors: Torres Diego A. , Rojas Abel Eduardo 
Published: July 2020

Abstract
Sanborn’s bonneted bat (Eumops hansae), an insectivorous Molossidae, is widely distributed in the Neotropics. However, records are scattered throughout its distribution with confirmed records from a few countries of South and Central America. Here, we record the first specimen of this species for Colombia. With this new record, the number of Eumops species in Colombia raises to eight and molossid species to 27. We recommend efforts of bat sampling to be directed towards habitats where molossid bats concentrate their foraging activities, thus increasing the knowledge of these rare bats and their occurrence in museum collections.
Time-varying optical vortices enabled by time-modulated metasurfaces
Authors: Barati Sedeh Hooman , Salary Mohammad Mahdi , Mosallaei Hossein 
Published: July 2020

Abstract
In this paper, generation of optical vortices with time-varying orbital angular momentum (OAM) and topological charge is theoretically demonstrated based on time-modulated metasurfaces with a linearly azimuthal frequency gradient. The topological charge of such dynamic structured light beams is shown to continuously and periodically change with time evolution while possessing a linear dependence on time and azimuthal frequency offset. The temporal variation of OAM yields a self-torqued beam exhibiting a continuous angular acceleration of light. The phenomenon is attributed to the azimuthal phase gradient in space-time generated by virtue of the spatiotemporal coherent path in the interference between different frequencies. In order to numerically authenticate this newly introduced concept, a reflective dielectric metasurface is modelled consisting of silicon nanodisk heterostructures integrated with indium-tin-oxide and gate dielectric layers on top of a mirror-backed silicon slab which renders an electrically tunable guided mode resonance mirror in near-infrared regime. The metasurface is divided into several azimuthal sections wherein nanodisk heterostructures are interconnected via nanobars serving as biasing lines. Addressing azimuthal sections with radio-frequency biasing signals of different frequencies, the direct dynamic photonic transitions of leaky-guided modes are leveraged for realization of an azimuthal frequency gradient in the optical field. Generation of dynamic twisted light beams with time-varying OAM by the metasurface is verified via performing several numerical simulations. Moreover, the role of modulation waveform and frequency gradient on the temporal evolution and diversity of generated optical vortices is investigated which offer a robust electrical control over the number of dynamic beams and their degree of self-torque. Our results point toward a new class of structured light for time-division multiple access in optical and quantum communication systems as well as unprecedented optomechanical manipulation of objects.
Been There, Done That
Authors: Jensen Klaus Bruhn 
Published: July 2020

Abstract
Digital media have been defined as meta-media that integrate new as well as old media on a single technological platform. As such, digital media enable new forms of meta-communication about the conditions under which communication is accomplished. The resulting meta-data bear witness to who was present, when, where and doing what, and these meta-data remain present for system administrators, regulators, marketers and other third parties to reinterpret and recycle. This article outlines the importance of meta-communication for contemporary communication theory, examines mediated presence as an instance of meta-communication, and addresses the implications of digitally mediated presence for current issues of surveillance.