bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of the Combination of Ankle-brachial Index and Percentage of Mean Arterial Pressure at Ankle for Improving Prediction of All-cause Mortality in type 2 Diabetes Mellitus
Authors: Li Yu-Hsuan , Sheu Wayne Huey-Herng , Lee I-Te 
Published: July 2020

Abstract
Background: Peripheral artery disease (PAD) in lower extremities is a common complication in type 2 diabetes and has shown to be associated with mortality. The ankle-brachial index (ABI) is a simple noninvasive method to screen PAD, but has limited sensitivity. We hypothesized that using the percentage of mean arterial pressure (%MAP) and the ABI in combination would improve prediction of mortality.Methods: We retrospectively collected the data of patients with type 2 diabetes who had undergone measurement of ABI and %MAP at our hospital. We separated the cohort into four groups according to the ABI and %MAP values, and examined these indices were associated with mortality.Results: A total of 5101 patients (mean age, 65 ± 11 years) were enrolled. During the follow-up period (median, 22.9 months), 266 (4.8%) of enrolled patients died. The combination of ABI and %MAP was significantly better at predicting mortality than ABI alone. (C index: 0.62 [95% CI: 0.57, 0.65] vs. 0.57 [95% CI: 0.53, 0.62], P = 0.038). In multivariate analysis (with ABI >0.90 and %MAP ≤45% as the reference group), the highest risk of mortality was seen in patients with ABI ≤0.90 and %MAP >45% (hazard ratio = 1.983 [95% CI: 1.380, 2.848], P < 0.001).Conclusions: Adding %MAP to ABI appears to significantly improve the predictive ability for all-cause mortality in patients with type 2 diabetes.
The effectiveness of listening to the Holy Quran to improve mental disorders and psychological well-being: Systematic review and meta-analysis
Authors: Abd-alrazaq Alaa , Malkawi Ashraf A , Maabreh Ahmed H , Alam Tanvir , Bewick Bridgette M , Akhu-Zaheya Laila , Househ Mowafa 
Published: July 2020

Abstract
Background: Listening to the Quran is one of spiritual therapies that have been used for treating mental disorders. Many studies have been conducted to assess the effect of listening to the Quran on mental health and psychological wellbeing. Several reviews were conducted to summarise results of such evidence. However, they either focused on studies published in a certain country (Iran), focused on certain setting (intensive care unit), or were written by Persian language. Moreover, none of them synthesised results of studies statistically.Objective: The study aimed to assess the effectiveness of listening to the Quran to improve mental disorders and psychological well-being by summarizing and pooling the findings of previous literature.Methods: A systematic review was conducted to accomplish this objective. The search sources included 6 bibliographic databases (e.g., MEDLINE, PsycINFO, CINHAL), the search engine “Google Scholar”, and backward and forward reference list checking of the included studies and relevant reviews. Two reviewers independently carried out the study selection, data extraction, risk of bias assessment, and quality of evidence evaluation. Results of the included studies were synthesized narratively and statistically, as appropriate.Results: Of 1724 citations retrieved, 11 studies met the eligibility criteria. Of these studies, 7 were included in meta-analysis. The evidence showed that listening to the Quran is significantly effective in improving state anxiety, trait anxiety, general anxiety, depression, stress and mental health. However, the evidence quality ranged from very low to low due to the high risk of bias, heterogeneity, and impression.Conclusion: Listening to the Quran has the potential to improve mental disorders and psychological well-being. Until high-quality studies approve its effect, health professionals and individuals should consider listening to the Quran as a complementary therapy to already available interventions. Researchers should conduct further studies to compare the effectiveness of reciting and listening to the Quran and Al-Ruqya Al-Shariya with active interventions on mental disorders and psychological well-being among Muslims and non-Muslims from different countries.
A general onepot-method for nucleic acid detection with CRISPR-Cas12a
Authors: Guanghui Tang , Gong Jiaojiao , Kan Lijuan , Zhang Xiuming , He Ying , Pan Jiaqiang , Zhao Liping , Tian Jie , Lin Sili , Lu Zhouyu , Xue Liang , Wang Chaojun , Li Qianyun 
Published: July 2020

Abstract
CRISPR/Cas12a system has been shown promising for nucleic acid diagnostics due to its rapid, portable and accurate features. In combination with isothermal amplification technology, single-copy sensitivity can be achieved. However, cleavage of the amplicons and primers by the cis- and trans-activity of Cas12a hinders the attempts to integrate the amplification and detection steps into a single reaction.
Through phosphorothioate modification of primer and design of crRNA that allow for the cutting site locating at the modified site of the primer, we realized onepot detection of SARS-CoV-2 with single-copy sensitivity. We also identified the activated Cas12a has a much higher affinity to C nucleotide-rich reporter than others. By applying such reporters, we significantly reduced the reaction time required for the lateral-flow readout. Furthermore, to improve the specificity of the strip-based assay, we created a novel reporter and, when combined with a customized strip, the unspecific signal could be completely eliminated. This established system termed Targeting DNA by Cas12a-based Eye Sight Testing in Onepot Reaction (TESTOR) was validated using clinical cervical samples for human papillomaviruses (HPVs) detection.
Our system represents a general approach to integrating the nucleic acid amplification and detection into a onepot reaction in CRISPR-Cas systems, highlighting its potential as a rapid, portable and accurate detection platform of nucleic acids.
Role of Physiotherapy in Long Term Physical and Mental Health of People Recovered From COVID 19: A Systematic Review Protocol
Authors: Gyanpuri Vyom , Dhiman Neetu , Pathak Abhishek , Singh Om Prakash 
Published: July 2020

Abstract
Background: the objective of the study to design a protocol on the effectiveness of physiotherapy on long term physical and mental health of recovered patients from coronavirus disease 2019. Methods: The following electronic databases will be searched from inception to June 2020: PubMed, EMBASE, Web of Science, China National Knowledge Infrastructure, Chinese Biomedical Literature Databases, and other databases. We will include all published documents regarding this topic. Two separate individuals will analyse studies and select accordingly after removal of duplicate studies. Then, final screening, assessment of quality of the articles and data analysis will be done. Meta-analyses, subgroup analysis, and descriptive analysis will be performed based on the included data conditions. Results: Methodological heterogeneity analysis of current evidence will be provided from Physical health outcomes like Barthel Index or Functional Independence measure scale and questionnaires describing health status like Physical Health Questionnaire and Mental health outcomes like SRQ-20, Hamilton Depression scale or Hamilton Anxiety scale.Conclusion: This study will provide the evidence regarding the importance of physiotherapy in future physical and mental health of recovered COVID-19 patients, when performed during treatment of disease in acute hospital management.PROSPERO registration number: CRD42020190863
Coal petrology analysis and implications in depositional environments from Upper Cretaceous to Miocene: a study case in the Eastern Cordillera of Colombia
Authors: Guatame Clara , Rincón Marco 
Published: July 2020

Abstract
Coal petrological characteristics along the Piedemonte Llanero and the reconstruction of the deposit environment were obtained from macerals and micro-lithotypes analysis since these data provide information about the processes and prevalent conditions during the peat formation. We analyzed seams from Cenomanian to Miocene geological units (Chipaque Formation, Palmichal Group, Arcillas del Limbo Formation, and San Fernando Formation). Coal range decreases gradually from high-volatile C bituminous (HVCB) in the Chipaque Formation to sub-bituminous C in the San Fernando Formation. The coals are enriched in macerals of vitrinite, whereas the liptinite and inertinite concentrations vary according to the stratigraphic position. The micro-lithotypes are bi-maceral and tri-macerals, being the highest concentrations of clarite and vitrinertoliptite. The results of the facies analysis show that the peat in which the coals developed is mainly of arboreal and herbaceous affinity (rich in lignin and cellulose). Peats are ombrotrophic (rainfed) to mesotrophic (transitional or mixed mires) with variations in the flooding surface and influxes of brackish water. Good tissue preservation is inferred from the wet conditions in forest swamps with few humification and gelation. According to the micro-lithotypes composition, the peat environment was deduced as estuarine system, evolving to lacustrine environment of the deltaic system, both restricted by changes in sea level, which are evidenced by oxic and anoxic periods in the analyzed sequence.
The Value of High-flow Nasal Cannula Oxygen Therapy in Treating Patients With Severe Novel Coronavirus Pneumonia
Authors: Teng Xiao-bao , Shen Ya , Han Ming-feng , Yang Gang , Zha Lei , Shi Jing-feng 
Published: July 2020

Abstract
Objective

This study aimed to investigate the value of high-flow nasal cannula (HNFC) oxygen therapy in treating patients with severe novel coronavirus pneumonia (COVID-19).
Methods

The clinical data of 22 patients with severe COVID-19 were collected. The heart rate (HR), respiratory rate (RR) and oxygenation index (PO2/FiO2) at 0, 6, 24 and 72 hours after treatment were compared between the HFNC oxygen therapy group and the conventional oxygen therapy (COT) group. In addition, the white blood cell (WBC) count, lymphocyte (L) count, C-reactive protein (CRP) and procalcitonin (PCT) were compared before and at 72 hours after oxygen therapy treatment.
Results

Of the included patients, 12 were assigned to the HFNC oxygen therapy group and 10 were assigned to the COT group. The differences in HR, RR, PaO2/FiO2, WBC, L, CRP and PCT at 0 hours between the two groups were not statistically significant. At 6 hours after treatment with the two oxygen therapies, HR, RR and PaO2/FiO2 were better in the HFNC oxygen therapy group than in the COT group (p < 0.05), while at 24 and 72 hours after treatment with the two oxygen therapies, PaO2/FiO2 was better in the HFNC oxygen therapy group than in the COT group (p < 0.05), but the differences in HR and RR were not statistically significant. At 72 hours after treatment, L and CRP had significantly improved in the HFNC oxygen therapy group compared with the COT group, but the differences in WBC and PCT were not statistically significant. The length of stay in the intensive care unit (ICU) and the total length of hospitalization were shorter in the HFNC oxygen therapy group than in the COT group, and the differences between the two groups were statistically significant.
Conclusion

Compared with COT, early application of HFNC oxygen therapy in patients with severe COVID-19 can significantly improve oxygenation and RR, and HFNC oxygen therapy can improve the infection indexes of patients and reduce the length of stay in the ICU of patients. Therefore, it has high clinical application value.
Splenic Infarction and Infectious Diseases in Korea
Authors: Im Jae Hyoung , Chung Moon-Hyun , Lee Hye-Jin , Kwon Hea Yoon , Baek JiHyeon , Jang Ji-Hun , Lee Jin-Soo 
Published: July 2020

Abstract
Background
Although the etiology of splenic infarction (SI) is multi-factorial, the nature of its relationship with infectious diseases is not well understood. We thus aimed to investigate the relationship between SI and infection using a retrospective approach.
Methods
We reviewed the hospital records of patients with SI who visited Inha University Hospital (Incheon, Republic of Korea) between January 2008 and December 2018. We collected and analyzed data on the patients’ clinical presentation, causative pathogens, risk factors, and radiologic findings.
Results
Of the 353 patients with SI, 101 patients with infectious conditions were enrolled in the study and their data were analyzed to identify an association between SI and infection. Ten patients were diagnosed as having infective endocarditis (IE), and 26 patients had bacteremia without IE. Twenty-seven patients had systemic infection due to miscellaneous causes (negative result on conventional automatic blood culture), such as the following intracellular organisms: parasites (12 cases of malaria and 1 case of babesiosis), bacteria (five cases of scrub typhus), viruses (one case each of Epstein–Barr virus infection and cytomegalovirus infection) or not identified pathogen (seven cases). Splenomegaly was more common among patients with miscellaneous systemic infection, and infarction involving other organs was rare. Twenty-one patients had localized infections (e.g. respiratory, intra-abdominal, or skin and soft tissue infection), and most of them (18 of 21) had other risk factors of SI.
Conclusions
In this study, various infectious conditions were found to be associated with SI, and intracellular organisms were the most common pathogens observed. Further studies are needed to examine other possible etiologies and the underlying pathophysiologic mechanisms.
Renal Failure and Hepatitis Following Ingestion of Raw Grass Carp Gallbladder: A Case Report
Authors: Zhou Lina , Dong Shaoshao , Zhang Shengze , Huang Wen 
Published: July 2020

Abstract
Background: Fish gallbladder has long been used as folk remedy in Asian countries.Multiple organ damage after fish gallbladder ingestion resulting in near mortality has been known to occur.Here,we describe a case of grass carp gallbladder poisoning and review the literature.Case Presentation: A previously healthy, 50-year-old woman was admitted to our hospital with a 2-day history of generalized abdominal pain and repeated vomiting following ingestion of 2 raw, grass carp gallbladders in an attempt to alleviate her cough. She developed anuria on day 4 with markedly elevated serum creatinine, urea, bilirubin, alanineaminotransferase, and aspartate aminotransferase.Based on thorough evaluation of her history and prompt biochemical investigations, we diagnosed her with acute renal failure and hepatitis secondary to fish gallbladder poisoning.Her renal biopsy revealed acute tubular necrosis.And she underwent six sessions of conventional hemodialysis due to renal failure. Supportive treatment, like gastric mucosal protectant and liver protectant were administered for targeted organ protection.The patient’s liver function gradually recovered and serum creatinine was 164 ummol/l at discharge on day 24. Over a period of 2-week follow-up, her renal function completely recovered. Conclusion: The purpose of this paper is to highlight the need for physicians to be mindful of the toxic complications of raw grass carp gallbladder ingestion and to promote its awareness among the people to help reduce this incidence of food poisoning.
A Different Point of View: The Evaluation of Motor Imagery Perspectives in Patients With Sensorimotor Impairments in A Longitudinal Study
Authors: Gäumann Szabina , Gerber Rahel Sarah , Suica Zorica , Schuster-Amft Corina 
Published: July 2020

Abstract
BackgroundMotor imagery (MI) has been successfully applied in neurological rehabilitation. Little is known about the spontaneous selection of the MI perspectives in patients with sensorimotor impairments. What MI perspective is selected: internal (first- person view), or external (third-person view)? The aim was to evaluate the MI perspective preference in patients after stroke (STR), with Multiple Sclerosis (MS) or Parkinson’s disease (PD).MethodsIn a longitudinal study including four measurement sessions over two weeks, MI ability and MI perspective preference in both visual and kinaesthetic imagery modalities were assessed using the Kinaesthetic and Visual Imagery Questionnaire including 20 items (KVIQ-20), mental rotation, and mental chronometry. Additionally, patients' activity level was assessed. Descriptive statistical analyses were performed regarding different age- (≤44, 45-63, 64≤) and activity levels (inactive, partially active, active), and KVIQ-20 movement classifications (axial, proximal, distal, upper and lower limb).ResultsIn total, 55 in- and outpatients (25 SRT, 25 MS, 5 PD; 25 females; mean age 58±14 years) were included. At the first measurement session, the mean mental rotation score was 27±4.1 out of 32. For mental chronometry, a congruency ratio of 1.0±0.3 was determined. The KVIQ-20 scores for the visual and kinaesthetic subscales were 62.4±16.2 and 58.2±17.2. The internal MI perspective was favoured in 66.5% on the visual subscale and in 72.7% on the kinaesthetic subscale. The external perspective was preferred in 30.3% on the visual subscale and in 26.5% on the kinaesthetic subscale. Over the four measurement sessions, patients became more consistent in their MI perspective selection. MI perspective changes occurred mainly during imagination of shoulder, arm and neck movements. During imagination of foot and finger movements their MI perspective was more constant. Results showed a tendency to use an external perspective in patients older than 64 years and in patients with a descreasing physical activity level. Axial and proximal movements were commonly imagined using the external perspective. ConclusionIt is recommended to evaluate the spontaneous MI perspective selection to design patient-specific MI training interventions. Distal movements (foot, finger) may be an indicator when evaluating the consistency of the MI perspective in patients with sensorimotor impairments. Trial registrationThis is a research project involving persons other than a clinical trial according to the Human Research Act other than clinical (non-clinical trial). Registered: EKNZ 2015-172, 19. Mai 2015
Non‑invasive prostate cancer detection by measuring expression level of miR-21 and miR-214 in urine
Authors: Emamvirdizadeh Alireza , Jamshidian Faranak , Hashemi Mehrdad , Nooraei Saghi , Entezari Maliheh 
Published: July 2020

Abstract
Background: Prostate cancer is the most prevalent cancer among men worldwide. Diagnosis in this cancer is primarily done using aggressive methods, such as biopsy. Laboratory methods, such as measurement of prostate specific antigen (PSA) in the blood, do not have high sensitivity and specificity. MicroRNAs, a group of diagnostic biomarkers, can be used to diagnose diseases such as cancer. MicroRNA is small, non-coding, single-stranded RNA with a length of 21-23 nucleotides. The present study was undertaken to investigate changes in the expression level of miR-21 and miR-214 in the urine to detect prostate cancer. Methods: Testing was done on 70 urine samples from prostate cancer patients (32 metastatic and 38 non-metastatic) and 30 from healthy individuals with negative biopsy reports as the control group. Changes in the expression level of miR-21 and miR-214 in the urine were investigated by using qRT-PCR. Results: miR-21 showed a significant increase in expression (p = 0.003) and miR-214 showed a significant decrease in expression (p = 0.000) over the results of the control group. The specificity, sensitivity and AUC for combined panels of both microRNAs were 100%, 72.14% and 0.721 and for PSA were 63.33%, 61.43% and 0.620, respectively. Conclusions: The results show that miR-21 and miR-214 show significant changes in expression in patients with prostate cancer compared to the control group. A combined panel of miR-21 and miR-214 can be used as a non-invasive method for detecting prostate cancer with higher sensitivity and specificity than the PSA test.
Patterns of breast, prostate and cervical cancer incidence and mortality in Colombia: An administrative registry data analysis
Authors: Vargas Juliana Alexandra Hernández , Barbosa Paula Ximena Ramírez , Quijano Ana Milena Gil , García Ana María Valbuena , Merchán Lizbeth Acuña , González Jaime 
Published: July 2020

Abstract
Background
Cancer is widely recognized as a global public health problem. Breast, prostate and cervical cancer are among the most frequent types in developing countries. Assessing their incidence and mortality by regions and municipalities is important to guide evidence-based health policy. Our aim was to describe the incidence and mortality trends for breast, cervical and prostate cancer across regions and municipalities in Colombia during 2018.
Methods
We performed a cross-sectional analysis with data from people with breast, prostate or cervical cancer, reported to the National Administrative Cancer Registry during 2018. A descriptive analysis was performed. Age-standardized incidence and mortality rates were estimated at national, regional and municipal levels. Finally, we identify the regions and municipalities with significantly higher or lower incidence and mortality rates compared to national estimations.
Results
Breast cancer was the most frequent type among all new cases and deaths in Colombia. Breast, prostate and cervical cancer incidence and mortality rates were: 18,69 (CI 95%: 18,15–19,25) and 10,48 (CI 95%: 10,07–10,91); 11,34 (CI 95%: 10,90 − 11,78) and 7,58 (CI 95%: 7,22 − 7,96); 5,93 (CI 95%: 5,62 − 6,25) and 4,31 (CI 95%: 4,05 − 4,58), respectively. Eastern region had both, incidence and mortality rates, significantly lower than national for all types of cancer. By municipalities, there were a heterogeneous pattern. Nonetheless, Agua de Dios (Cundinamarca), had one of the highest incidence rates for all types.
Conclusions
We observed clear differences in cancer incidence and mortality across regions and municipalities, depending on each type of cancer. Our findings are important to improve screening coverage, early detection and treatment in the country.