bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physiological response, function of sweat glands, and hair follicle cycling in cattle in response to fescue toxicosis and hair genotype
Authors: Eisemann Joan H , Ashwell Melissa S , Devine Thomas L , Poole Daniel H , Poore Matt H , Linder Keith E 
Published: January 2020

AbstractFescue toxicosis is a syndrome that results when cattle consume toxic endophyte-infected tall fescue. The objective of this study was to compare the response in physiological variables, sweat gland function, hair follicle cycling, and gene expression to feeding a total mixed ration that included tall fescue haylage and tall fescue seed containing a toxic endophyte (EI) or tall fescue haylage containing a nontoxic novel endophyte (EN) in beef heifers (Angus × Senepol heifers, n = 31) with 2 different hair genotypes. Numbers in each subgroup were as follows: novel endophyte, heterozygous slick (EN-S; n = 8), novel endophyte, homozygous hairy (wild type, EN-W; n = 7), endophyte-infected, heterozygous slick (EI-S; n = 10), and endophyte-infected, homozygous hairy (wild type, EI-W; n = 6). Physiological measurements were taken weekly for 7 wk. Data were analyzed using the MIXED procedure of SAS including dietary fescue treatment (EN vs. EI) and hair genotype (S vs. W) as main effects, day as a repeated measure, and temperature–humidity index (THI) as a covariate. Skin biopsies were taken before treatment initiation and on day 37 of treatment. Average surface temperature (ST) increased as the THI increased (P &lt; 0.0001). Average ST was greater (P &lt; 0.01) for animals fed EI than for animals fed the EN fescue diet, and greater (P &lt; 0.01) for animals with the W genotype compared with animals with the S genotype. The difference between heifers with the S and W genotype was greater at greater THI (genotype × day interaction, P &lt; 0.01). Transepidermal water loss (TEWL) was greater (P &lt; 0.05) for animals with the S genotype compared with the W genotype and greater (P &lt; 0.05) for heifers with the S genotype than for heifers with the W genotype when fed EI (36.7, 38.5, 30.0, and 38.7 g/m2 per hour for EN-W, EN-S, EI-W, and EI-S, respectively). The fraction of follicles in telogen in plucked hair samples for heifers fed EI was greater for animals with the S genotype than the W genotype (fraction in telogen: 0.456, 0.565, 0.297, 0.702 for EN-W, EN-S, EI-W, and EI-S, respectively; diet × genotype interaction, P &lt; 0.05). Fraction of follicles in anagen was the opposite. EI fescue resulted in increased ST, changes in hair follicle cycling that support greater hair growth, and decreased TEWL for heifers with the W genotype compared with S genotype, suggesting greater heat stress in response to EI.
At least 3 days of adaptation are required before indigestible markers (chromium, titanium, and acid insoluble ash) are stabilized in the ileal digesta of 60-kg pigs, but values for amino acid digestibility are affected by the marker
Authors: Kim Beob G , Lee Su A , Park Kyu R , Stein Hans H 
Published: January 2020

Abstract
An experiment was conducted to 1) test the hypothesis that a minimum adaptation period to diets used in ileal amino acid (AA) digestibility experiments with pigs is needed and 2) to test the null-hypothesis that ileal digestibility and basal endogenous losses of AA are not affected by the indigestible marker used. Eight ileal-cannulated barrows with an initial BW of 58.1 ± 4.3 kg were randomly allotted to a 2-period crossover design with 2 diets and 4 pigs per diet in each period. A soybean meal-based diet and an N-free diet were prepared. Both diets contained 0.4% chromium oxide, 0.4% titanium dioxide, and 0.4% Celite (a source of acid insoluble ash; AIA). Pigs were provided feed in a daily amount of 3 times the maintenance requirement for metabolizable energy, and 2 equal meals were provided each day. Ileal digesta samples were collected from 0800 to 2000 h on each day during the two 9-d collection periods. There was no period by diet interactions observed. Marker concentrations in ileal digesta were analyzed separately for each day, and the point where the concentration of each marker was stabilized in the digesta was determined using a linear broken-line analysis. For pigs fed the soybean meal diet, the breakpoints for Cr, Ti, and AIA in ileal digesta were 2.70, 2.45, and 3.77 d, respectively. In pigs fed the N-free diet, the breakpoints for Cr, Ti, and AIA in ileal digesta were 2.52, 2.39, and 2.29 d, respectively. Based on the pooled data, the basal endogenous losses of most AA calculated using Cr as an indigestible marker were less (P &lt; 0.05) than the values calculated using Ti, but greater (P &lt; 0.05) compared with values calculated based on AIA. The standardized ileal digestibility of most AA in soybean meal calculated using Cr or Ti as a digestibility marker were greater (P &lt; 0.05) than the digestibility values calculated using AIA. In conclusion, 3 d of adaptation is required before markers are stabilized in the ileal outflow if Cr or Ti is used as an indigestible marker and 4 d of adaptation is required if AIA is the marker. Values for AA digestibility calculated using Cr or Ti as the marker are not different, but greater compared with values calculated using AIA as the marker.
Overexpressing microRNA-34a overcomes ABCG2-mediated drug resistance to 5-FU in side population cells from colon cancer via suppressing DLL1
Authors: Xie Zheng-Yuan , Wang Fen-Fen , Xiao Zhi-Hua , Liu Si-Fu , Tang Sheng-Lan , Lai Yue-Liang 
Published: January 2020

Abstract
Colon cancer side population (SP) cells are a small subset of cancer cells that have cancer stemness capacity and enhanced drug resistance. ABCG2 is a multidrug resistance-related protein in SP cells and has been demonstrated to be regulated by Notch signalling pathway. Recently, microRNAs are reported to play a critical role in SP cell fate. However, their role in ABCG2-mediated drug resistance in colon cancer SP cells remains unclear. In the current study, the different expressions of miR-552, miR-611, miR-34a and miR-5000-3p were compared within SP and non-SP cells, which were separated from human colon cancer cell lines (SW480 and LoVo). We found that miR-34a was significantly down-regulated in SP cells and that overexpressing miR-34a overcame drug resistance to 5-fluorouracil (5-FU). The luciferase reporter assay indicated that miR-34a negatively regulated DLL1, a ligand of Notch signalling pathway, via binding with 3′-untranslated region of its messenger RNA. In addition, overexpressing miR-34a overcame ABCG2-mediated resistance to 5-FU via DLL1/Notch pathway in vitro, and suppressed tumour growth under 5-FU treatment in vivo. In conclusion, our findings suggest that miR-34a acts as a tumour suppressor via enhancing chemosensitivity to 5-FU in SP cells, which provides a novel therapeutic target in chemotherapy-resistant colon cancer.
A new erymoid lobster (Decapoda: Glypheidea: Erymidae) from the Upper Cretaceous of British Columbia, Canada, and a summary of Erymoidea from North America
Authors: Feldmann Rodney M , Schweitzer Carrie E , Haggart James W 
Published: January 2020

AbstractThe description of a new species of an erymid lobster, Stenodactylina beardi, from the Upper Cretaceous Haslam Formation of the Nanaimo Group on Vancouver Island, British Columbia, Canada, brings to fifteen the number of Erymidae in North America. The species are arrayed within five genera based upon configuration of carapace groove morphology, resulting in two new combinations, Stenodactylina bordenensis (Copeland, 1960) and S. foersteri (Feldmann, 1979). The new species exhibits for the first time a male pleopod and accessory structures within Erymoidea. We also provide a list of the North American species of Erymoidea.
τ-curve: introduction of cusps to aesthetic curves☆
Authors: Miura Kenjiro T , Suzuki Sho , Usuki Shin , Gobithaasan R U 
Published: January 2020

Abstract
Yan, Schiller, Wilensky, Carr, and Schaefer pointed out that one of the demerits of clothoid interpolation is a jumping behavior during the deformation of the curve. This phenomenon occurs because the clothoid curve cannot have a cusp, where the curve is kinked or the direction of the curve is abruptly changed. We discuss how to introduce cusps for the log-aesthetic curve including the clothoid curve and propose to use for the representation of a curve the direction angle instead of curvature and define a new curve named τ-curve, which is defined by the direction angle of the curve.
Durability of Cross-Protection by Different Schedules of the Bivalent HPV Vaccine: The CVT Trial
Authors: Tsang Sabrina H , Sampson Joshua N , Schussler John , Porras Carolina , Wagner Sarah , Boland Joseph , Cortes Bernal , Lowy Douglas R , Schiller John T , Schiffman Mark , Kemp Troy J , Rodriguez Ana Cecilia , Quint Wim , Gail Mitchell H , Pinto Ligia A , Gonzalez Paula , Hildesheim Allan , Kreimer Aimée R , Herrero Rolando ,   for the Costa Rica HPV Vaccine Trial (CVT) Group
Published: January 2020

Abstract

Background
The Costa Rica HPV Vaccine Trial has documented cross-protection of the bivalent HPV vaccine against HPV31/33/45 up to 7 years after vaccination, even with one dose of the vaccine. However, the durability of such protection remains unknown. Here, we evaluate the efficacy of different schedules of the vaccine against HPV31/33/45 out to 11 years postvaccination, expanding to other nontargeted HPV types.

Methods
We compared the rates of HPV infection in vaccinated women with the rates in a comparable cohort of unvaccinated women. We estimated the average vaccine efficacy (VEavg) against incident infections and tested for a change in VE over time.

Results
Among 3-dose women, we observed statistically significant cross-protection against HPV31/33/45 (VEavg = 64.4%, 95% confidence interval [CI] = 57.7% to 70.0%). Additionally, we observed borderline, statistically significant cross-protection against HPV35 (VEavg = 23.2%, 95% CI = 0.3% to 40.8%) and HPV58 (VEavg = 21.2%, 95% CI = 4.2% to 35.3%). There was no decrease in VE over time (two-sided Ptrend &gt; .05 for HPV31, -33, -35, -45, and -58). As a benchmark, VEavg against HPV16/18 was 82.0% (95% CI = 77.3% to 85.7%). Among 1-dose women, we observed comparable efficacy against HPV31/33/45 (VEavg = 54.4%, 95% CI = 21.0% to 73.7%). Acquisition of nonprotected HPV types was similar between vaccinated and unvaccinated women, indicating that the difference in HPV infection rates was not attributable to differential genital HPV exposure.

Conclusions
Substantial cross-protection afforded by the bivalent vaccine against HPV31/33/45, and to a lesser extent, HPV35 and HPV58, was sustained and remained stable after 11 years postvaccination, reinforcing the notion that the bivalent vaccine is an effective option for protection against HPV-associated cancers.
Evaluation of Durability of a Single Dose of the Bivalent HPV Vaccine: The CVT Trial
Authors: Kreimer Aimée R , Sampson Joshua N , Porras Carolina , Schiller John T , Kemp Troy , Herrero Rolando , Wagner Sarah , Boland Joseph , Schussler John , Lowy Douglas R , Chanock Stephen , Roberson David , Sierra Mónica S , Tsang Sabrina H , Schiffman Mark , Rodriguez Ana Cecilia , Cortes Bernal , Gail Mitchell H , Hildesheim Allan , Gonzalez Paula , Pinto Ligia A ,   for the Costa Rica HPV Vaccine Trial (CVT) Group
Published: January 2020

Abstract

Background
The authors investigated the durability of vaccine efficacy (VE) against human papillomavirus (HPV)16 or 18 infections and antibody response among nonrandomly assigned women who received a single dose of the bivalent HPV vaccine compared with women who received multiple doses and unvaccinated women.

Methods
HPV infections were compared between HPV16 or 18-vaccinated women aged 18 to 25 years who received one (N = 112), two (N = 62), or three (N = 1365) doses, and age- and geography-matched unvaccinated women (N = 1783) in the long-term follow-up of the Costa Rica HPV Vaccine Trial. Cervical HPV infections were measured at two study visits, approximately 9 and 11 years after initial HPV vaccination, using National Cancer Institute next-generation sequencing TypeSeq1 assay. VE and 95% confidence intervals (CIs) were estimated. HPV16 or 18 antibody levels were measured in all one- and two-dose women, and a subset of three-dose women, using a virus-like particle-based enzyme-linked immunosorbent assay (n = 448).

Results
Median follow-up for the HPV-vaccinated group was 11.3 years (interquartile range = 10.9–11.7 years) and did not vary by dose group. VE against prevalent HPV16 or 18 infection was 80.2% (95% CI = 70.7% to 87.0%) among three-dose, 83.8% (95% CI = 19.5% to 99.2%) among two-dose, and 82.1% (95% CI = 40.2% to 97.0%) among single-dose women. HPV16 or 18 antibody levels did not qualitatively decline between years four and 11 regardless of the number of doses given, although one-dose titers continue to be statistically significantly lower compared with two- and three-dose titers.

Conclusion
More than a decade after HPV vaccination, single-dose VE against HPV16 or 18 infection remained high and HPV16 or 18 antibodies remained stable. A single dose of bivalent HPV vaccine may induce sufficiently durable protection that obviates the need for more doses.
Primary Tau Pathology, Not Copathology, Correlates With Clinical Symptoms in PSP and CBD
Authors: Robinson John L , Yan Ning , Caswell Carrie , Xie Sharon X , Suh EunRan , Van Deerlin Vivianna M , Gibbons Garrett , Irwin David J , Grossman Murray , Lee Edward B , Lee Virginia M -Y , Miller Bruce , Trojanowski John Q 
Published: January 2020

Abstract
Distinct neuronal and glial tau pathologies define corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP). Additional Alzheimer disease, TDP-43, and Lewy body copathologies are also common. The interplay of these pathologies with clinical symptoms remains unclear as individuals can present with corticobasal syndrome, frontotemporal dementia, PSP, or atypical Parkinsonism and may have additional secondary impairments. We report clinical, pathological, and genetic interactions in a cohort of CBD and PSP cases. Neurofibrillary tangles and plaques were common. Apolipoprotein E (APOE)ε4 carriers had more plaques while PSP APOEε2 carriers had fewer plaques. TDP-43 copathology was present and age-associated in 14% of PSP, and age-independent in 33% of CBD. Lewy body copathology varied from 9% to 15% and was not age-associated. The primary FTD-Tau burden—a sum of the neuronal, astrocytic and oligodendrocytic tau—was not age-, APOE-, or MAPT-related. In PSP, FTD-Tau, independent of copathology, associated with executive, language, motor, and visuospatial impairments, while PSP with Parkinsonism had a lower FTD-Tau burden, but this was not the case in CBD. Taken together, our results indicate that the primary tauopathy burden is the strongest correlate of clinical PSP, while copathologies are principally determined by age and genetic risk factors.
A repressor complex silencing ABA signaling in seeds?
Authors: Nonogaki Hiroyuki 
Published: January 2020

AbstractSeed dormancy is induced primarily by abscisic acid (ABA) and maintained through elevated levels of ABA sensitivity in seeds. The core mechanisms of ABA-imposed seed dormancy are emerging, but it is still unclear how these blockages in seeds are eliminated during after-ripening, or what molecular events in imbibed seeds are responsible for the initial stages of germination induction. Some pieces of evidence suggest that a repressor complex, which potentially triggers seed germination through the suppression of ABA signaling components, might be present in seeds. The usual suspect, protein phosphatase 2C, which inactivates kinases and shuts down ABA signaling in the major dormancy pathway, is possibly associated with this complex. Other members, such as WD40 proteins and histone deacetylase subunits, homologs of which are found in the flowering repressor complex, perhaps constitute this complex in seeds. The repressor activity could counteract the dormancy mechanisms in an overwhelming manner, through well-coordinated inactivation and turnover of germination-suppressing transcription factors, which is probably accompanied by chromatin silencing and transcriptional repression of the transcription factor target genes. This review provides a perspective on a putative seed germination-inducing repressor complex, including its possible modes of action and upstream regulators.
UDAT: Compound quantitative analysis of text using machine learning
Authors: Shamir Lior 
Published: January 2020

Abstract
Computing machines allow quantitative analysis of large databases of text, providing knowledge that is difficult to obtain without using automation. This article describes Universal Data Analysis of Text (UDAT) —a text analysis method that extracts a large set of numerical text content descriptors from text files and performs various pattern recognition tasks such as classification, similarity between classes, correlation between text and numerical values, and query by example. Unlike several previously proposed methods, UDAT is not based on frequency of words and links between certain key words and topics. The method is implemented as an open-source software tool that can provide detailed reports about the quantitative analysis of sets of text files, as well as exporting the numerical text content descriptors in the form of comma-separated values files to allow statistical or pattern recognition analysis with external tools. It also allows the identification of specific text descriptors that differentiate between classes or correlate with numerical values and can be applied to problems related to knowledge discovery in domains such as literature and social media. UDAT is implemented as a command-line tool that runs in Windows, and the open source is available and can be compiled in Linux systems. UDAT can be downloaded from http://people.cs.ksu.edu/∼lshamir/downloads/udat.
Candidate LBV stars in galaxy NGC 7793 found via HST photometry + MUSE spectroscopy
Authors: Wofford Aida , Ramírez Vanesa , Lee Janice C , Thilker David A , Della Bruna Lorenza , Adamo Angela , Van Dyk Schuyler D , Herrero Artemio , Kim Hwihyun , Aloisi Alessandra , Calzetti Daniela , Chandar Rupali , Dale Daniel A , de Mink Selma E , Gallagher John S , Gouliermis Dimitrios A , Grasha Kathryn , Grebel Eva K , Sacchi E , Smith Linda J , Úbeda Leonardo , Walterbos Rene A M , Hannon Stephen , Messa Matteo 
Published: January 2020

ABSTRACT
Only about 19 Galactic and 25 extragalactic bonafide luminous blue variables (LBVs) are known to date. This incomplete census prevents our understanding of this crucial phase of massive star evolution which leads to the formation of heavy binary black holes via the classical channel. With large samples of LBVs one could better determine the duration and maximum stellar luminosity which characterize this phase. We search for candidate LBVs (cLBVs) in a new galaxy, NGC 7793. For this purpose, we combine high spatial resolution images from two Hubble Space Telescope (HST) programs with optical spectroscopy from the Multi Unit Spectroscopic Explorer (MUSE). By combining PSF-fitting photometry measured on F547M, F657N, and F814W images, with restrictions on point-like appearance (at HST resolution) and H α luminosity, we find 100 potential cLBVs, 36 of which fall in the MUSE fields. Five of the latter 36 sources are promising cLBVs which have MV ≤ −7 and a combination of: H α with a P-Cygni profile; no [O i]$\, \lambda 6300$ emission; weak or no [O iii]$\, \lambda 5007$ emission; large [N ii]/H α relative to H ii regions; and [S ii]$\, \lambda 6716$/[S ii]$\, \lambda 6731\sim 1$. It is not clear if these five cLBVs are isolated from O-type stars, which would favour the binary formation scenario of LBVs. Our study, which approximately covers one fourth of the optical disc of NGC 7793, demonstrates how by combining the above HST surveys with multi-object spectroscopy from 8-m class telescopes, one can efficiently find large samples of cLBVs in nearby galaxies.
A cosmic UV/X-ray background model update
Authors: Faucher-Giguère Claude-André 
Published: January 2020

ABSTRACT
We present an updated model of the cosmic ionizing background from the UV to the X-rays. Relative to our previous model, the new model provides a better match to a large number of up-to-date empirical constraints, including: (1) new galaxy and AGN luminosity functions; (2) stellar spectra including binary stars; (3) obscured and unobscured AGN; (4) a measurement of the non-ionizing UV background; (5) measurements of the intergalactic H i and He ii photoionization rates at z ∼ 0−6; (6) the local X-ray background; and (7) improved measurements of the intergalactic opacity. In this model, AGN dominate the H i ionizing background at z ≲ 3 and star-forming galaxies dominate it at higher redshifts. Combined with the steeply declining AGN luminosity function beyond z ∼ 2, the slow evolution of the H i ionization rate inferred from the high-redshift H i Ly α forest requires an escape fraction from star-forming galaxies that increases with redshift (a population-averaged escape fraction of $\approx 1{{\ \rm per\ cent}}$ suffices to ionize the intergalactic medium at z = 3 when including the contribution from AGN). We provide effective photoionization and photoheating rates calibrated to match the Planck 2018 reionization optical depth and recent constraints from the He ii Ly α forest in hydrodynamic simulations.
The faint radio source population at 15.7 GHz – IV. The dominance of core emission in faint radio galaxies
Authors: Whittam I H , Green D A , Jarvis M J , Riley J M 
Published: January 2020

ABSTRACT
We present 15-GHz Karl G. Jansky Very Large Array observations of a complete sample of radio galaxies selected at 15.7 GHz from the Tenth Cambridge (10C) survey. 67 out of the 95 sources (71 per cent) are unresolved in the new observations and lower frequency radio observations, placing an upper limit on their angular size of ∼2 arcsec. Thus, compact radio galaxies, or radio galaxies with very faint jets, are the dominant population in the 10C survey. This provides support for the suggestion in our previous work that low-luminosity ($L\lt 10^{25} \, \textrm{W~Hz}^{-1}$) radio galaxies are core dominated, although higher resolution observations are required to confirm this directly. The 10C sample of compact, high-frequency selected radio galaxies is a mixture of high-excitation and low-excitation radio galaxies and displays a range of radio spectral shapes, demonstrating that they are a mixed population of objects.
Global and local mechanical properties control endonuclease reactivity of a DNA origami nanostructure
Authors: Suma Antonio , Stopar Alex , Nicholson Allen W , Castronovo Matteo , Carnevale Vincenzo 
Published: January 2020

Abstract
We used coarse-grained molecular dynamics simulations to characterize the global and local mechanical properties of a DNA origami triangle nanostructure. The structure presents two metastable conformations separated by a free energy barrier that is lowered upon omission of four specific DNA staples (defect). In contrast, only one stable conformation is present upon removing eight staples. The metastability is explained in terms of the intrinsic conformations of the three trapezoidal substructures. We computationally modeled the local accessibility to endonucleases, to predict the reactivity of twenty sites, and found good agreement with the experimental data. We showed that global fluctuations affect local reactivity: the removal of the DNA staples increased the computed accessibility to a restriction enzyme, at sites as distant as 40 nm, due to an increase in global fluctuation. These results raise the intriguing possibility of the rational engineering of allosterically modulated DNA origami.