bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Early Physical and Pulmonary Rehabilitation for Severely and Critically ill COVID-19 Patients: A Retrospective, Cohort, and Multicenter Study
Authors: Qi Di , Yan Xiaofeng , Xiang Jianglin , Peng Junnan , Yu Qian , Tang Xumao , Tong Jin , Feng Longhua , Yuan Jing , Song Yuyan , Yuan Guodan , Wang Daoxin 
Published: September 2020

Abstract
BackgroundEffects of early rehabilitation therapy in severe and critical COVID-19 patients remains to be elucidated. MethodsWe recruited 80 severely and critically ill COVID-19 patients in Chongqing from January 21 to March 15, 2020, who had received rehabilitation therapies or standard treatments within 72 h of intensive care unit (ICU) admission. We analyzed mortality rates, length of stay in the ICU and hospital, ventilator-free days, and adverse events during hospitalization. Respiratory function, independent functional status, muscle strength, exercise capacity and life quality were measured at hospital discharge and during a three-month follow-up. ResultsWe found no significant differences between the intervention and control groups in terms of ICU, hospital, and 28-day mortality rates, and lengths of stay in the ICU and hospital. Additionally, early rehabilitation enhanced the duration of ventilator-free days, with no increased adverse events and complications. Total lung capacity and carbon monoxide diffusion capacity, Barthel index, and functional independence measure for patients in the intervention group were all higher than those in the control group at hospital discharge and one month after discharge. Compared to the control group, patients in the intervention group had significantly higher Medical Research Council scores and greater walking distance capacities within 6 min at hospital discharge, as well as one month and three months after discharge. The St. George's Respiratory Questionnaire score was lower in the intervention group than in the control group at one month and three months after hospital discharge.ConclusionsEarly physical and pulmonary rehabilitation is safe and effective for severely and critically ill COVID-19 patients to promote their functional, physical, and psychological recovery.
Prognostic and clinical significance of lncRNA NKILA in tumors: a meta-analysis
Authors: Tang Xin , Qiu Shipei , Ma Xiang , Lu Ming , Feng Jiaxi , Jing YongLi , Zhao Qinghong 
Published: September 2020

Abstract
Background

lncRNA NKILA is a newly discovered long non-coding RNA, and some studies have shown that lncRNA NKILA has certain clinical prognostic value in malignant tumors. In this study, we used meta-analysis to integrate existing literature to further evaluate the clinic relevance between lncRNA NKILA expression level and cancers.
Materials and Methods

We conducted a meta-analysis based on literature reporting lncRNA NKILA expression in various cancers published before 25, May 2020 by PubMed, Embase, and Web of Science. The quality ratings of the included studies were assessed according to the Newcastle-Ottawa Scale. After rigorous screening, a total of 8 articles and 859 patients were included in our study. Hazard ratios (HRs) and odds ratios (ORs) were used to demonstrate the relationship between NKILA and prognosis by using Stata 15.0 software.
Results

The results show overexpression level of lncRNA NKILA is significantly associated with better overall survival (pooled HR = 0.45, 95%CI:0.35–0.59, P < 0.001, fixed-effects model). Furthermore, increased expression level of lncRNA NKILA was associated with negative lymph node metastasis (positive vs. negative,OR = 0.27, 95%CI:0.18–0.42, P < 0.001, fixed-effects model) and earlier clinical stage (TNM III/IV vs. I/II: OR = 0.34, 95%CI:0.25–0.46, p < 0.001, fixed-effects model).
Conclusions

Our study indicated lncRNA NKILA was a novel biomarker for prognosis in cancers. It could serve as a tumor-suppressive role.
Antiplasmodial Potential of Traditional Phytotherapy of Some Remedies Used in The Treatment of Malaria in India
Authors: Sheth Navin , Vadalia Jigna , Sanandia Jalpa , Bhatt Vaibhav 
Published: September 2020

Abstract
Background: The increasing problem of drug resistance to most of the available antimalarial therapies is a recurring issue. To overcome this issue, new antiplasmodial drugs are needed. Many plants have been use for treatment of malaria by traditional healer in India. The purpose of this research was to evaluate seven medicinal plants used against malaria by indigenous people in India, validate their use and identify the plant with the best antiplasmodial properties. Methods: Methanol, hydro alcoholic (60:40) and aqueous extracts from seven ethnomedicinal plants were screened on chloroquine-sensitive (MRC-2) and chloroquine-resistant (RKL-9) strain of Plasmodium falciparum by schizont maturation inhibition assay and inhibition of Plasmodium falciparum lactate dehydrogenase (PfLDH) activity. Results: Out of 21 extracts, hydro alcohol extract of B. variegate showed the highest inhibition of schizont maturation with 81.77±0.96% against MRC-2 and 78.08±3.76% against RKL-9 strain. In PfLDH inhibition assay, Methanol and hydro alcohol extract of B. variegate showed moderate antiplasmodial activity with IC50 24.65 μg/mL and 39.42 μg/mL, respectively against MRC-2 strain. Methanol extract of B. variegate also exhibited moderate activity with IC50 28.71 μg/ml against RKL-9 strain. Conclusion: The present study provided scientific evidence for indigenous Indian medicinal plants as a source of antiplasmodial agents. This finding supports the continued exploration of traditional medicines in the search for new antimalarial agents. The compounds responsible for the observed antiplasmodial effects in B. variegate are under investigation.
Impact of Trauma Center Care on Mortality in Gangwon Province in Korea&nbsp;
Authors: AN GYOJIN , Kim Yoon-Seop , Kim Hye Sim , Kang Chan Young , Hwang Sung Oh , Lee Kang Hyun , Kim Hyun , Cha Kyoung-Chul , Cha Yong Sung , Kim Oh Hyun 
Published: September 2020

Abstract
Background: Al though controversial, there has been a consensus that compared with non-regional trauma centers, regional trauma centers have survival benefits. In a predominantly rural province with a single regional trauma center, we compared the in-hospital mortality of all trauma patients and severely injured patients between regional and non-regional trauma centers.Methods: Using data extracted from the National Emergency Department Information System in Korea, we examined all trauma patients who visited emergency departments in Gangwon province between January 2015 and December 2017. The International Classification of Disease-Based Injury Severity Score (ICISS) was used to categorize the severity of the patients. Propensity score matching was used for balancing the severity between the two groups.Results: Of 23,510 trauma patients, 2,857 and 20,653 were treated in regional and non-regional trauma centers, respectively. After propensity score matching, all patients in the non-regional trauma center group had a 6.27-fold higher risk of mortality than those in the regional trauma center group; severely injured patients—defined as those with ICISS < 0.9—in the non-regional trauma center group had a 4.90-fold higher risk of mortality than those in the regional trauma center group. ICISS cutoff values for mortality were 0.9015 and 0.8737 for the non-regional and regional trauma center groups, respectively.Conclusion: Conventional paradigms of trauma systems can be used in predominantly rural Korean provinces, because trauma care in regional trauma centers conferred better survival benefits than that in non-regional trauma centers. Additionally, severely injured patients should be transported to regional trauma centers from the trauma scene.
Unique Transcriptome and Gene Expression Analysis of Rice Seedling Reveals Different Cadmium Response Regulatory Mechanisms Between Indica and Japonica Rice
Authors: Tong Shan , Luo Xin , Khanzada Hira , Wassan Ghulam Mustafa , Cui Licao , Wu Guangliang , Tan Jingai , Liu Shilei , Li Caijin , Wang Peng , Zhang Xiangyu , Xu Jie , He Haohua , Bian Jianmin 
Published: September 2020

Abstract
Background: In general, the Cd content in indica rice is usually higher than that in japonica. However, the mechanism for this discrepancy is unclear. Thus, understanding the genetic and molecular basis of Cd stress between indica and japonica is extremely important for rice improvement programs.Results: In this study, two varieties of rice, japonica 02428 and indica CH891, were continuously exposed to Cd and seedlings of the two varieties at two critical stages (3rd and 5th day) were selected for the dynamic genes analysis by transcriptome method. The results showed that CH891 was more sensitive to Cd than 02428, and a total of 7,204 and 6,670 differently expressed genes (DEGs) associated with Cd stress were detected at 3rd day and 5th day. Furthermore, we divided these DEGs into three categories: SCR (sensitive variety with Cd-responsive), RCR (resistant variety with Cd-responsive) and CCR (common Cd-responsive). The enriched metabolic pathways analysis of DEGs preferentially expressed in a stage-specific and cultivars-specific manner, and secondary metabolic processes were enriched in SCR while protein metabolism and plant hormone were enriched in RCR. The diverted metabolic pathways might be the major cause for different response mechanism of Cd in indica and japonica rice. Conclusion: These results provide a novel insight into the Cd response mechanism in rice seedlings between different varieties, and these important Cd-responsive DEGs were frequently involved in specific biological processes and metabolic pathways that might provide a novel insight over indica and japonica rice Cd response mechanism difference.
The prognostic significance and regulatory networks of DAP3 in hepatocellular carcinoma microenvironment based on bioinformatics analysis
Authors: Jiang Jie , Sun Bo , Zhu Xinyan , Zhang Yu , Xiong Jie , Zhang Minbo , Qian Yiting , Liu Ruilin , Yang Wenzhuo 
Published: September 2020

Abstract
Background: Death-associated protein 3 (DAP3) is a GTP-binding protein in the component of the small subunit of the mitochondrial ribosome. Abnormal expression of DAP3 potentially correlates with carcinogenesis. However, the specific functions of DAP3 in hepatocellular carcinoma (HCC) are still not clarified.Methods: The expression of DAP3 in different cancer types was analyzed using TIMER and Oncomine, and DAP3 expression in HCC was detected using Oncomine, GEPIA and UALCAN. DAP3 promoter methylation was shown via MEXPRESS. The effect of DAP3 on HCC prognosis was analyzed via Kaplan-Meier plotter, GEPIA and UALCAN. Moreover, co-expressed genes with DAP3 and their regulators, kinases, miRNA and transcription factor targets were identified using LinkedOmics. Furthermore, cBioPortal was used to detect the genetic alteration of DAP3. Finally, TIMER was utilized to evaluate the correlations between DAP3 and immune cell infiltration, while the correlation between DAP3 and three immune factors was detected through TIDISB.Results: DAP3 expression was significantly high in several tumor tissues, including HCC. The promoter methylation level of DAP3 in HCC tissues was remarkably lower compared with normal tissues. Additionally, high DAP3 expression was related to overall survival (OS). Functional network analysis indicated that DAP3 regulated the translational elongation, ribonucleoprotein complex biogenesis, tRNA metabolic process and mitochondrial respiratory chain complex assembly. Moreover, DAP3 expression represented strong correlations with the immune cell infiltration and immune factors in HCC. Conclusions: Our results indicated that DAP3 acted as a potential prognostic marker in HCC, laying a groundwork for further study of DAP3 in HCC.
Effect of Age, Sex, and Breed on the Blood Biochemistry and Physiological Constants of Dogs From 4 Weeks to &gt; 52 Weeks of Age.
Authors: Tristán Teódulo Quezada , Navarrete Ana Luisa Montoya , Santillán Samuel Lozano , Martínez Raúl Ortiz , Flores Arturo Gerardo Valdivia , Martínez Lizbeth Martinez , Lopez Maria Carolina De Luna 
Published: September 2020

Abstract
Background: Blood biochemistry and reference intervals help to differentiate between healthy and ill patients as well as to provide information for the prognosis, evaluation, and monitoring of a patient; however, these intervals are often obtained from adult animals. It is essential, hence, to understand that puppies and adults are physiologically different, which justifies the need to obtain age-specific biochemical reference intervals. The aim of this research was to assess the potential effect of age, sex, breed, and interaction on routine biochemical analytes and physiological constants (body temperature, heart rate, and respiratory rate) in addition to establish age-specific reference intervals. In order to carry out the research, we selected 197 healthy dogs of different sex and breed classified by age: group I (4-8 wk), group II (9-24 wk), group III (25-52 wk), and group IV (>52 wk). The biochemical analysis measured the enzymatic activity of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), and concentration of cholesterol, triglycerides, total proteins, albumin, globulins, glucose, urea, and creatinine. Statistical analyses used the Analysis of Variance (ANOVA) and General Linear Model (GLM), which allows the comparison of multiple factors at two or more levels (p < 0.05). Results: The results of this study showed that ALT, total protein, albumin, globulin, urea, creatinine, and body temperature levels were lower in puppies compared to adult dogs (p < 0.05) while the enzymatic activity of ALP, LDH, glucose concentration, and heart rate were higher. Moreover, in small breeds, the serum creatinine levels were lower (p < 0.05) whereas sex and interaction did not show a significant effect (p > 0.05).Conclusions: Some biochemical components evince influence by age. For this reason, this research offers specific reference intervals to help the veterinary clinician to interpret the biochemical results of puppies with accuracy.
Symptom, Adopting Healthy Life Style, and Quality of Life in Patients with Liver Cirrhosis: A Cross-Sectional Study
Authors: Lee Myung Kyung , CHUNG Woo Jin 
Published: September 2020

Abstract
Background: Previous studies have not considered a broad range of symptoms and the association with healthy behavior and quality of life of patients with liver cirrhosis. Objectives: The purposes of the study were to examine the association of symptom with adopting exercise and consuming fruits and vegetables, and to identify factors associated with quality of life in patients with liver cirrhosis.Methods: This cross-sectional study enrolled 91 consecutive patients with liver cirrhosis in one tertiary general hospital in South Korea between February 2016 and January 2017. Each study participant completed a self-administered questionnaire that measured symptom, stage-of-change in performing exercise and consumption of fruits and vegetables, and the Korean version of the 36-item Short-Form Health Survey. Multivariate logistic regression analysis and multiple regression models was used respectively to examine the association of each symptom with engaging in exercise and increasing consumption of fruits and vegetables and to evaluate factors affecting quality of life.Results: Experiencing nausea was associated with increased intensity of exercise but experiencing shortness of breath was associated with decreased intensity of exercise. Experiencing right upper quadrant pain was associated with increased consumption of fruits and vegetables and muscle cramps, anorexia, right upper quadrant pain and body pain, itching, ascites or edema, bruising, and change in appearance negatively affected quality of life.Conclusions: The results suggest that the types of symptoms experienced by a patient with liver cirrhosis hinder or promote the patient’s adoption of exercise and dietary behavior. Experiencing symptoms may negatively affect quality of life. Caregivers should provide supportive care to patients with liver cirrhosis, which includes assessing and managing symptoms to improve quality of life.
Five crucial prognostic-related autophagy genes stratified female breast cancer patients aged 40-60 years
Authors: Li Xiaolong , Zhang Hengchao , Liu Jingjing , Li Ping , Sun Yi 
Published: September 2020

Abstract
Background: Autophagy is closely related to the progression of breast cancer.The aim of this study is to establish a prognostic-related model comprised of hub autophagy-genes(AGs) to assess patitents prognosis. Simultaneously, the model can guide clinicians to make up individualized strategies and stratify patients aged 40-60 years based on risk level.Methods: The hub AGs were identified through univariate COX regression and LASSO regression. The functions and alterations of these selected AGs were analyzed as well.Moreover,the multivariate COX regression and correlation analysis between hub AGs and clinicopathological parameters were done. Results: Totally,33 prognostic-related AGs were obtained from the univariate COX regression(P<0.05).SERPINA1, HSPA8, HSPB8, MAP1LC3A, and DIRAS3 were identified to constitute the prognostic model by the LASSO regression. The survival curve of patients in high-risk and in low-risk group was statistically significant(P<0.05).The 3-year and 5-year ROC displayed that their AUC value reached 0.762 and 0.825,respectively. Stage and riskscore were independent risk factors relevant about prognosis.RB1CC1, RPS6KB1, and BIRC6 were identified as the most predominant mutant genes. It was found that AGs were mainly involved in regulating the endopeptidases synthesis and played important roles in ErbB signal pathway. SERPIN1, riskscore were closely related to stage(P<0.05); HSPA8, riskscore were closely related to T staging(P<0.05); HSPB8 was closely related to N staging(P<0.05). Conclusions: Our prognostic model had relatively robust predictive ability on prognosis for patients aged 40-60 years.If stage was added into the prognostic model, the predictive ability would be more powerful.
The Impact of Foreign Aid on Economic Growth in Ethiopia
Authors: Gebresilassie Belay Asfaw , Gebre Girma Gezmu 
Published: September 2020

Abstract

This study analyzes the impact of foreign aid on economic growth in Ethiopia based on time series annual data for the period of 1974 to 2017. Autoregressive distributed lag Approach to Co-integration and Error Correction Model was applied in order to investigate the long-run and short-run relationship between dependent and the independent variables. The empirical results from econometrics model reveal that foreign aid has negative impact on economic growth in both long run and short run and statistically significant at 1 percent significant level. The negative and significant error correction term shows that the short run disequilibrium adjusts to its long run equilibrium by 84.6 percent each year. The important policy implication of this study suggests that more effort has to be made to improve the negative impact of foreign aid, mainly because of existence of poor institutional arrangement that contributes the fund to unproductive sectors. The government has to ensure, a close monitoring and consistent management strategies, which is used to avoid misallocation and mismanagement problems and has to ensure that foreign aid is linked to the productive sectors to optimize the benefits.
Wavelets for Long Waves: Was Kondratieff’s Intuition Right?
Authors: Focacci Antonio 
Published: September 2020

Abstract
The validity of the Kondratieff’s theory of long-waves is still a controversial issue among historians, economic, social and political science scholars. In this work, both original Kondratieff’s data (never processed by wavelet analysis in their whole dataset) jointly with additional among the longest and most representative economic indicators are investigated. By the application of this statistical technique, the main purpose of the paper is to furnish an additional information to the literature. We trace evidence on the presence of coherent periodicities in the case of original Kondratieff time series and for other relevant and up-dated economic indicators as well.(JEL C22, E32, E37)
Lung adenocarcinoma isolated metastasizing to pancreas a case report and review
Authors: Wang Shupeng , Liu Kaimeng , Gu Yue , Tan Ludong , Jia Feng , Liu Yahui 
Published: September 2020

Abstract
BACKGROUND: Lung cancers are prone to metastasis. It is commonly associated with metastases in the brain, bone, and liver.However, isolated pancreatic metastasis are extremely rare in lung cancer patients。CASE SUMMARY: A Chinese man underwent pulmonary lobectomy for adenocarcinrcinoma 6 years ago. He was referred to our department because that postoperative reexamination revealed space occupying lesions in the neck of the pancreas.Abdomen CT showed a space occupying lesions in the neck of the pan-creas.,and no abnormality was found in any other organ. Therefore, it was considered to pancreatic carcinoma. Pancreatectomy of the pancreatic body and tail, as well as splenectomy, were performed,and he was given four courses of pemetrexed and Carboplatin chemotherapy after one month of operation. Then the gefitinib was given. A year after surgery, the patient survived without tumor.CONCLUSION: Secondary pancreatic tumors are rare in clinical practice.To our knowledge, this is the first report of isolated pancreatic metastasis of lung cancer in China and it is the longer tumor-free survival in patients with isolated pancreatic metastasis of lung cancer.However,the value of surgical treatment for isolated metastasis of lung cancer needs further discussion.