bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of progressive muscle relaxation training on negative emotions and sleep quality in COVID-19 patients
Authors: Xiao Chun-Xiu , Lin Yan-Juan , Lin Ren-Qin , Liu An-Na , Zhong Gui-Qin , Lan Cai-Feng 
Published: November 2020

Abstract
This study investigates the effect of progressive muscle relaxation training on negative mood and sleep quality in Coronavirus Pneumonia (COVID-19) patients.
COVID-19 is an emerging infectious disease, and there is still uncertainty about when the outbreak will be contained and the effectiveness of treatments. Considering that this disease is highly contagious, patients need to be treated in isolation. This may lead to psychological symptoms such as anxiety and depression, and even sleep problems.
This study is a clinical observation study.
Participants included 79 COVID-19 patients admitted to a designated hospital for COVID-19 patients in Wuhan from February to March, 2020. Patients were selected and assigned to the control group and the observation group according to their wishes, with 40 and 39 cases in each group, respectively. The control group received routine treatment and nursing, and the observation group received progressive muscle relaxation training, in addition to the routine treatment and nursing. We compared scores of the Pittsburgh Sleep Quality Index Scale (PSQI), the Generalized Anxiety Disorder (GAD-7), and the Patient Health Questionnaire (PHQ-9) before and after the intervention.
There was no significant difference in PSQI, GAD-7, and PHQ-9 scores between the control group and the observation group before the intervention (P > .05). After the intervention, the difference in scores of PSQI, GAD-7, and PHQ-9 in the 2 groups were statistically significant (P < .05).
Progressive muscle relaxation training can significantly reduce anxiety and depression and improve sleep quality in COVID-19 patients during isolation treatment.
Progressive muscle relaxation training was shown to improve the treatment effect of patients and is worthy of clinical promotion.
Supportive psychological intervention on psychological disorders in clinical medicine students with English Learning Difficulties
Authors: Wen Hong-li , Feng Chen , Zhang Shu-ling , Li Xiao-wei 
Published: November 2020

Abstract

Background:
This study aims to examine the effect of supportive psychological intervention (SPI) on psychological disorders (PD) in clinical medicine students (CMS) with English Learning Difficulties (ELD).

Methods:
We will perform a comprehensive literature search from the following databases: Cochrane Library, MEDLINE, EMBASE, Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure. All databases will be performed from their inception to the present without language limitation by 2 independent reviewers. We will also look for grey literature, such as conference proceedings, dissertations or theses. Newcastle-Ottawa Scale will be used to assess study quality, and RevMan 5.3 software will be applied to carry out statistical analysis.

Results:
This study will summarize the most recent evidence to assess the effect of SPI on PD in CMS with ELD.

Conclusion:
This study may provide helpful evidence of SPI on PD in CMS with ELD.

OSF registration number:
osf.io/tah2s.
Thyroid dysfunction and cardiovascular events in patients with chronic kidney disease
Authors: Liu Tongtong , Guan Yingjie , Li Juan , Mao Huimin , Zhan Yongli 
Published: November 2020

Abstract

Background:
Cardiovascular disease is the main cause of death in patients with chronic kidney disease (CKD). Studies have found that hypothyroidism can significantly increase cardiovascular risk. Meanwhile, hypothyroidism is a common complication of CKD, but the correlation between hypothyroidism and cardiovascular risk in CKD patients has not been verified and paid enough attention. We therefore plan to conduct a systematic review and meta-analysis to explore whether hypothyroidism was independently predictive for the cardiovascular risk in patients with CKD.

Methods:
We will search in PubMed, Embase Database, Web of Science, China National Knowledge Infrastructure (CNKI), China Biology Medicine Database (CBM), and Wanfang Database, and include the cross-sectional studies, case--control studies, and cohort studies that explore the association between hypothyroidism and cardiovascular risk in CKD patients. According to the eligibility criteria, two researchers will independently screen the retrieved literature, evaluate the methodological quality, and extract data. We will combine the extracted data based on STATA and TSA software.

Results:
This systematic review will assess the association between hypothyroidism and cardiovascular risk in CKD patients based on the incidence of cardiovascular events in CKD people with hypothyroidism.

Conclusions:
This study will provide more evidence for the correlation between hypothyroidism and cardiovascular risk in CKD patients, which will contribute to the management and clinical practice of CKD population.

Ethics and dissemination:
This protocol is based on available literatures so that the ethical approval and informed consent are not applicable. The results of this study will be published in a peer-reviewed journals or relevant conferences.

Protocol registration number:
INPLASY2020100022.
Efficacy and safety of warm needle treatment for scapulohumeral periarthritis
Authors: Wang Xiaoyu , Hai Xinghua , Jiang Dongli , Yin Lianjun , Li Huanan , Wang Qi , Liu Fang , Xu Guoqiang , Sun Qing 
Published: November 2020

Abstract

Background:
To evaluate the effectiveness and safety of warm needle acupuncture (WNA) treatment for Scapulohumeral periarthritis.

Methods:
Relevant randomized controlled trials will be searched from the databases of Pubmed, the Cochrane Library, Embase, CNKI, Wanfang Database, CBM and VIP Database from their inception to September 2021. The primary outcomes are effective rate, visual analog scale score. The secondary outcomes are Constant-Murley score, Japanese Orthopaedic Association scores, adverse events. Two reviewers will independently select studies, collect data, and assess the methodology quality by the Cochrane risk of bias tool. The Stata 14.0 will be used for meta-analysis.

Results:
This study is ongoing and will be submitted to a peer-reviewed journal for publication.

Conclusion:
This study will provide an assessment of the current state of WNA for the scapulohumeral periarthritis, aiming to show the efficacy and safety of WNA treatment.

Ethics and dissemination:
There is no requirement of ethical approval and informed consent, and it will be in print or published by electronic copies.

Registration:
INPLASY2020100049
Postauricular injection glucocorticoid in the treatment of sudden hearing loss
Authors: Liang Jiao , Xie Hui , Chiang Han-Jen , Li Sha , Liu Zhiqing , Li Jiongke , Zeng Chenyi 
Published: November 2020

Abstract

Background:
Sudden hearing loss is an emergency health problem in the Department of Otolaryngology that must be treated in a timely manner, or may cause lifelong regrets. The application of postauricular injection of glucocorticoid is a popular treatment to recover patients hearing level in recent years. However, the effectiveness and safety of postauricular injection of glucocorticoid needs to be assessed systematically.

Methods and analysis:
The purpose of the study is to undertake a systematic review and meta-analysis on the effectiveness and safety of postauricular injection of glucocorticoid to treat patient diagnosed with sudden hearing loss. We will search the following databases from the date of publication to July 1, 2020: PubMed, EMBASE, Web of Science, the Cochrane Library, CNKI, Wanfang databases, the Chinese Biomedical Literature Database (CBM), the Chinese Science and Technology Periodical Database (VIP) and the Chinese Cochrane Centre's Clinical Trial Registry Platform. Observational studies regarding the association between postauricular injection of glucocorticoid and sudden hearing loss were written in English and Chinese were included. RevManV.5.3 software will be used for meta-analysis. According to the heterogeneity of the research results, fixed effects model, random effects model, subgroup analysis, sensitivity analysis, and others will be used. Ethics approval was not required for this protocol. The findings will be disseminated through journal articles and conference presentations.

Results:
Objectively, evaluate the efficacy and safety of postauricular injection of glucocorticoid for sudden hearing loss.

Conclusion:
To provide evidence-based medicine for glucocorticoid treatment methods in patients with sudden hearing loss.

OSF registration number:
DOI 10.17605/OSF.IO/N5RV3.
A comparison of the effects of acupoint injection combined with hyaluronic acid versus isolated hyaluronic acid for knee osteoarthritis
Authors: Zhou Xing , Xiang Kemeng , Yuan Xiangyao , Wang Zhenping , Li Kuanglin 
Published: November 2020

Abstract

Background:
Knee osteoarthritis (KOA) is a kind of degenerative osteoarthropathy, which causes joint pain and limited mobility, seriously affects the quality of life of the patient. Traditional Chinese Medicine acupuncture and moxibustion has been widely used to treat KOA, and acupoint injection is 1 of the acupuncture treatment methods. The purpose of this work is to evaluate the effectiveness of Acupoint injection combined with Hyaluronic Acid injection compared with isolated Hyaluronic Acid injection for KOA.

Methods:
We will search articles in 7 electronic databases including Chinese National Knowledge Infrastructure, Wanfang Data, Chinese Scientific Journals Database, Chinese databases SinoMed, PubMed, Embase, and Cochrane Library databases. All the publications, with no time restrictions, will be searched without any restriction of language and status, the time from the establishment of the database to October 2020. Two reviewers will independently assess the quality of the selected studies, NoteExpress and Excel software will be used to extract data, and the content will be stored in an electronic chart. Different researchers will separately screen the titles and abstracts of records acquired potential eligibility which comes from the electronic databases. Full-text screening and data extraction will be conducted afterward independently. Statistical analysis will be conducted using RevMan 5.4 software.

Results:
This study will evaluate the efficacy and safety of Acupoint injection combined with Hyaluronic Acid injection compared with isolated Hyaluronic Acid injection in the treatment of KOA, to provide high-quality, evidence-based clinical recommendations.

Trial registration number:
INPLASY2020100058

Conclusion:
This study will provide reliable evidence on whether Acupoint injection combined with Hyaluronic Acid injection compared with isolated Hyaluronic Acid injection is more effective in treating KOA.
Simultaneous renal clear cell carcinoma and primary clear cell carcinoma of the liver
Authors: Jiang Hua , Zhao Shanchao , Li Ganhong 
Published: November 2020

Abstract

Rationale:
Double primary clear cell carcinomas of the liver (PCCCL) and kidney are extremely rare; moreover, there have been no reported cases of adrenal metastasis from primary clear cell tumors of the liver.

Patient concerns:
A 47-year-old male patient was admitted to our clinic with space-occupying lesions in the left kidney and liver during a regular medical examination.

Diagnoses:
The tumors in the kidney and liver were diagnosed as primary clear cell carcinoma by histopathological examination.

Interventions:
The patient subsequently underwent nephron-sparing surgery of the left kidney and radical partial excision of the right liver lobe by laparoscopic surgery. Transcatheter arterial chemoembolization (TACE) was performed for the patient 2 weeks after tumor resection. One month after the operation, the patient started adjuvant therapy with sorafenib (400 mg twice per day orally). However, follow-up CT imaging revealed a solid mass measuring 1.9 × 2.0 × 2.0 cm3 in the right adrenal gland at 2 months postoperatively, and then the patient underwent radiofrequency ablation (RFA) for the right adrenal tumor.

Outcomes:
The patient remained cancer free for 2 years following the diagnosis despite early right adrenal metastasis.

Lessons:
Hepatocyte immunostaining is sufficient for the diagnosis of PCCCL.
Acupuncture therapy for treating postherpetic neuralgia
Authors: Yu Jie , Tu Mingqi , Shi Yan , Liu Yingjun , He Xiaofen , Qiu Fanghui , Xu Yunyun , Sun Ruohan , Jiang Yongliang , Fang Jianqiao 
Published: November 2020

Abstract

Background:
Postherpetic neuralgia (PHN) is the most common complication and sequela of herpes zoster (HZ) that greatly affects the life and emotional experience of patients. Acupuncture therapy has been confirmed as an effective and safe treatment for PHN. Several systematic reviews (SRs) and meta-analysis (MAs) have reported the evidence of acupuncture therapy for treating PHN. However, the evidence has not been systematically synthesized. This overview aims to synthesize and assess the reliability of evidence generated from these SRs and MAs of acupuncture therapy for PHN.

Methods:
We will conduct a systematic search of the China Biology Medicine (CBM), VIP database, Wangfang database, China National Knowledge Infrastructure (CNKI), Pubmed, Cochrane Library, Excerpt Medical Database (Embase), and Web of Science to identify eligible SRs and MAs, from their inception to October 31, 2020. We will use Assessment of Multiple Systematic Reviews-2 (AMSTAR2) for methodological quality assessment, Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) for report quality assessment, Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) for the quality of evidence assessment, and ROBIS for the bias assessment. Our reviewers will conduct systematic reviews, qualification evaluation, data extraction, methodological quality, and evidence quality screening in pairs. The outcomes include pain intensity, Quality of life (QoL), Hamilton Anxiety Scale (HAMA), Global impression, and adverse events. All the extracted data will be provided in tabular form to summarize characteristics of each review. The evidence will be a narrative synthesis of the type and content of the intervention and the results reported.

Results:
The results of this study will be published in a peer-reviewed journal.

Conclusions:
This overview will provide comprehensive evidence of acupuncture therapy for patients with PHN.

Ethics and dissemination:
This review will not involve private information of participants, so the ethical approval will not be required. The results will be disseminated in a peer-reviewed journal or conference presentation. Important protocol modifications will be updated on PROSPERO.

PROSPERO registration number:
CRD42020178738.
Factors associated with the depression among people with disabilities
Authors: Bi Yahong , Zhao Xincai , Zhou Yanyan , Lao Limin , Jiang Sunfang 
Published: November 2020

Abstract
Depression has become a growing health issue in the world and is projected to become a leading cause of global burden. However, there is little scientific research on the factors associated with depression in people with disabilities in China. In this cross-sectional study, we aimed to explore the prevalence and related factors of depression among people with disabilities in communities in mainland China.
Participants with disability certificates were recruited via face-to-face interviews to complete questionnaires. Contents include participants’ demographic characteristics, the Modified Barthel Index (MBI), chronic medical history, and the Patient Health Questionnaire-9 (PHQ-9).
A total of 1815 participants (M age = 60.35 ± 13.66) whose questionnaires are eligible were finally included. Among them the incidence rate of depressive symptoms was up to 39.9%. Multifactor regression analysis showed that grade I disability (odds ratio (OR) = 1.37, P < .05), impairment activities of daily living (OR = 3.23, P < .001), diabetes (OR = 1.43, P < .05), and hyperlipidemia (OR = 1.59, P < .001) were associated with depression in the disabled. However, intelligence disability is a protective factor of depression (OR = 0.69, P < .05).
The data demonstrates that the depression of the disabled should arouse the attention of our society. Furthermore, the interventions to disability degree, impairment activities of daily living, diabetes, and hyperlipidemia may help to improve the mental health of the disabled people.
The influence of social anxiety on interpersonal information processing in a military-life environment
Authors: Yin Qianlan , Dong Wei , Chen Aibin , Song Xiangrui , Hou Tianya , Cai Wenpeng , Deng Guanghui 
Published: November 2020

Abstract
Although social anxiety as a ubiquitous emotion impacting people's social behaviors has aroused much researchers’ interest in exploring its cognitive behavioral model, no previous study has focused on soldiers with different social anxiety within the context of the specific military environment.
To explore the associations between social anxiety and interpersonal information processing concerted on interpretation and judgment, the study may provide an intervention point for soldiers to ameliorate social anxiety and accommodate to the military-life environment.
A self-reported questionnaire and 2 behavioral tasks were conducted in the cross-section study to explore the associations.
Seventy-four soldiers were randomly recruited from a naval base. The Interpersonal Anxiety Scale was used to assess social anxiety of soldiers. Two behavioral tasks were designed to test the characteristics of interpersonal information processing, one for interpretation bias and the other for judgment bias.
This cross-sectional study showed social anxiety had a significant negative correlation with interpretation bias and abidance (as judgment bias), signaling that soldiers with higher levels of social anxiety had a stronger tendency to negative interpretation bias and showed lower abidance. The mediating effect analysis showed the interpretation bias could indirectly affect the soldier's abidance through social anxiety. Notably, none of the interaction effects of social anxiety and social information types were statistically significant; therefore, the level of social anxiety predetermined the abidance of soldiers.
Soldiers’ social anxiety has an influence on processing military-life interpersonal information, and it plays a certain intermediary role in the associations between low abidance and negative interpretation bias. The stronger negative interpretation bias than positive bias of soldiers, the higher social anxiety they could show with the less possibility to abide, which might result in behaviors against the military collective requirements. Social anxiety has the primary effect on the abidance of soldiers; hence, in the future, the interpretation bias modification could be a plausible cognitive-behavior therapy to help soldiers ameliorate social anxiety, thus contributing to enhancing their sense of belonging to the troops and accommodation to military life.
To study the intervention mechanism of pediatric massage on intestinal flora and host metabolism in children with anorexia
Authors: Gao Hanyuan , Zhang Xutong , He Wenjie , Zhao Xia , Han Juan , Li Dongmei , Yang Hanteng , Li Shengcai 
Published: November 2020

Abstract

Background:
As a common and frequent disease in pediatric patients, pediatric anorexia (PN) poses a serious threat to childhood growth and health. In recent years, societal changes in lifestyle and diet have increased the incidence of this PN, which has attracted extensive attention from both the medical community and parents. It has been shown that massage therapy represents an effective intervention for the treatment of anorexia, but investigation on its mechanism(s) of action remains limited. In this study, we will explore the biological mechanism(s) of PN from the perspective of intestinal flora, to further reveal its site of action and therapeutic mechanism(s).

Methods:
A total of 60 healthy children will be randomly selected for physical examination. According to a random number generated by a computer, children with anorexia who meet the inclusion criteria will be selected. In strict accordance with the time sequence of inclusion, subjects will be randomly assigned to either the massage or control group (n = 60 per group). The blank group will receive no treatment. Children in the massage group will receive a designated massage protocol. The control group will be administered oral Jianweixiaoshi tablets over 4 weeks. Each group will be compared for intestinal flora structure, fecal short chain fatty acids levels, serum trace elements, urine D-xylose-excretion rates, gastric fluid emptying, gastric motility, and hemoglobin levels before and after treatment.

Results:
We will review the clinical trial registry in China (http://www.chictr.org.cn/searchprojen.aspx), peer-reviewed journals and academic conferences.

Conclusion:
This study will verify the intervention mechanism(s) of pediatric massage on intestinal flora and host metabolism in children with anorexia.

Trial registration number:
ChiCTR2000033274
Body mass index and skeletal muscle index are useful prognostic factors for overall survival after gastrectomy for gastric cancer
Authors: Kim Eun Young , Jun Kyong Hwa , Kim Shinn Young , Chin Hyung Min 
Published: November 2020

Abstract
Among patients undergoing gastrectomy for gastric cancer, the impact of anthropometric indices on surgical outcomes is not well-established. The aim of this study was to evaluate the prognostic significance of the skeletal muscle index (SMI) and body mass index (BMI) on overall survival (OS) in patients with gastric cancer.
A total of 305 patients who underwent curative gastrectomy for gastric adenocarcinoma between January 2005 and March 2008 were enrolled. Patients were classified into groups based on the SMI and BMI. The SMI was measured by preoperative abdominal computed tomography (CT). The SMI groups were classified based on gender-specific cut-off values obtained by means of optimum stratification. BMI groups were divided according to the World Health Organization definition of obesity for Asians.
The mean SMI was 58.2 cm2/m2 and the mean BMI was 23.2 kg/m2. One hundred fifteen (37.7%) patients had sarcopenia based on the diagnostic cut-off values (56.2 cm2/m2 for men and 53.6 cm2/m2 for women). Apart from gender, there were no significant differences in patient characteristics or surgical outcomes between the SMI groups. In the underweight group, tumor (T) stage, tumor-node-metastasis (TNM) stage, number of retrieved lymph nodes, D2 dissection, and hospital stay were significantly increased compared with the overweight/obese group. High and low BMI, and low SMI, were independent prognostic factors for OS (hazard ratio [HR] = 2.355, 1.736, and 1.607, respectively; P = .009, .023, and .033, respectively).
SMI and BMI did not impact perioperative morbidity in patients undergoing gastrectomy for gastric cancer. Both SMI and BMI are useful prognostic factors for OS in gastric cancer patients after gastrectomy.