bluuebunny/crossref_metadata_2025_split huggingface dataset:
The incidence and characteristics of accelerated knee osteoarthritis among women: the Chingford cohort
Authors: Driban Jeffrey B. , Bannuru Raveendhara R. , Eaton Charles B. , Spector Tim D. , Hart Deborah J. , McAlindon Timothy E. , Lu Bing , Lo Grace H. , Arden Nigel K. 
Published: January 2020

AbstractBackgroundPrior research on accelerated knee osteoarthritis (AKOA) was primarily confined to the Osteoarthritis Initiative, which was enriched with people with risk factors for knee osteoarthritis (KOA). It is unclear how often AKOA develops in a community-based cohort and whether we can replicate prior findings from the Osteoarthritis Initiative in another cohort. Hence, we determined the incidence and characteristics of AKOA among women in the Chingford Study, which is a prospective community-based cohort.MethodsThe Chingford Study had 1003 women with quinquennial knee radiographs over 15 years. We divided the 15-year observation period into three consecutive 5-year phases. Within each 5-year phase, we selected 3 groups of participants among women who started a phase without KOA (Kellgren-Lawrence [KL] < 2): 1) incident AKOA developed KL grade ≥ 3, 2) typical KOA increased radiographic scoring (excluding AKOA), and 3) no KOA had the same KL grade over time. Study staff recorded each participant’s age, body mass index (BMI), and blood pressure at baseline, 5-year, and 10-year study visits. We used multinomial logistic regression models to test the association between groups (outcome) and age, BMI, and blood pressure at the start of each phase. The cumulative incidences and odds ratios (OR) from each phase were pooled using a fixed-effect meta-analysis model.ResultsThe person-based cumulative incidence of AKOA was 3.9% over 5 years (pooled estimate across the three 5-year phases). Among incident cases of KOA, AKOA represented ~ 15% of women with incident KOA. Women with AKOA were older than those with typical (OR = 1.56, 95%CI = 1.16–2.11) or no KOA (OR = 1.84, 95%CI = 1.40–2.43). Women with AKOA had a greater BMI than those without KOA (OR = 1.52, 95%CI = 1.17–1.97). We observed no association between group and blood pressure.ConclusionsIn a community-based cohort, > 1 in 7 women with incident KOA had AKOA. Like the Osteoarthritis Initiative, people with AKOA were more likely to have greater age and BMI.
Marginal bone resorption of posterior mandible dental implants with different insertion methods
Authors: Aliabadi Ehsan , Tavanafar Saeid , Khaghaninejad Mohammad Saleh 
Published: January 2020

AbstractBackgroundTo evaluated the marginal bone loss around dental implants by two insertion methods.MethodsEligible patients were divided into two groups; manual and mechanized groups. Peri-apical x-ray using a customized device to standardize the radiographs designed and used to take three periodical radiographs; after surgery, three months, and six months follow up. An independent t-test was used to compare the two groups regarding the average level of marginal bone loss (p < 0.05).ResultsAfter excluding dropouts, a total of 273 patients (120 males and 153 females, aged between 25 and 67 years old) were included in the study. The average marginal bone loss in the manual insertion method was 0.44 ± 0.84 mm, and 0.59 ± 0.20 mm, and for the mechanized method was 0.51 ± 0.20 mm and 0.67 ± 0.19 mm after three and six months, respectively. There was a significant difference in marginal bone loss after six months between the two groups(p < 0.001). However, no differences were observed after three months (p = 0.24).ConclusionsUnder the condition of this study, both techniques were safe and resulted in an acceptable amount of bone resorption; however, in the manual method, the less marginal bone loss occurred after six months.
Effects of a quasi-experimental study of using flipped classroom approach to teach evidence-based medicine to medical technology students
Authors: Huang Hsien-Li , Chou Chia-Pei , Leu Steve , You Huey-Ling , Tiao Mao-Meng , Chen Chih-Hung 
Published: January 2020

Abstract
Background
Flipped classroom is known to improve learning efficiency and to develop one’s ability to apply high-level knowledge. To investigate the effect of flipped classroom approach on teaching evidence-based medicine to medical technology students, we conducted a tailor-made six flipped classroom based EBM courses for medical technology students.

Methods
This study adopted a qusai-experimental design with 62 medical technology interns as the research object. Students in the experimental group attended the flipped classroom course, while students in the control group attended the traditional course. The learning outcomes were evaluated by Fresno test in both groups. Furthermore, to understand student’s perceptions on the flipped classroom approach, students in the experimental group were required to fill in a satisfaction survey and answer some open-ended questions.

Results
The Fresno test scores of the experimental group were significantly higher than that of the control group. From the results of the satisfaction survey, we know that students were satisfied with this course format. Students claimed that the flipped classroom approach could improve their learning efficiency and the interactions with teacher could help them to think more deeply.

Conclusions
To conclude, most students showed positive attitudes and views on flipped classroom strategy. Moreover, students’ questions were solved more effectively during class resulting in an improvement of effectiveness of evidence-based medicine trainings.
Implementing a sustainable health insurance system in Cambodia: a study protocol for developing and validating an efficient household income-level assessment model for equitable premium collection
Authors: Nakamura Haruyo , Amimo Floriano , Yi Siyan , Tuot Sovannary , Yoshida Tomoya , Tobe Makoto , Nomura Shuhei 
Published: January 2020

Abstract
Background
As elsewhere in low- and middle-income countries, due to limited fiscal resources, universal health coverage (UHC) remains a challenge in Cambodia. Since 2016, the National Social Security Fund (NSSF) has implemented a social health insurance scheme with a contributory approach for formal sector workers. However, informal sector workers and dependents of formal sector workers are still not covered by this insurance because it is difficult to set an optimal amount of contribution for such individuals as their income levels are inestimable. The present study aims to develop and validate an efficient household income-level assessment model for Cambodia. We aim to help the country implement a financially sustainable social health insurance system in which the insured can pay contributions according to their ability.

Methods
This study will use nationally representative data collected by the Cambodia Socio-Economic Survey (CSES), covering the period from 2009 to 2019, and involving a total of 50,016 households. We will employ elastic net regression analysis, with per capita disposable income based on purchasing power parity as the dependent variable, and individual and community-level socioeconomic and demographic characteristics as independent variables. These analyses aim to create efficient income-level assessment models for health insurance contribution estimation. To fully capture socioeconomic heterogeneity, sub-group analyses will be conducted to develop separate income-level assessment models for urban and rural areas, as well as for each province.

Discussion
This research will help Cambodia implement a sustainable social health insurance system by collecting optimal amount of contributions from each socioeconomic group of the society. Incorporation of this approach into existing NSSF schemes will enhance the country’s current efforts to prevent impoverishing health expenditure and to achieve UHC.
Attitude toward entrepreneurship, perceived behavioral control, and entrepreneurial intention: dimensionality, structural relationships, and gender differences
Authors: Vamvaka Vasiliki , Stoforos Chrysostomos , Palaskas Theodosios , Botsaris Charalampos 
Published: January 2020

AbstractDrawing on the theory of planned behavior, the main purpose of this cross-sectional study was to identify gender-related differences in the levels of and the interrelations among attitude toward entrepreneurship, perceived behavioral control, and entrepreneurial intention using multi-group structural equations modeling in which the dimensions of these constructs were disentangled and treated as latent variables that were indirectly inferred from multiple indicators. The sample of the study consisted of 441 Greek tertiary education undergraduate information technology students. The results showed that attitude consists of two components—one instrumental and one affective; perceived behavioral control is comprised of two factors—perceived self-efficacy and perceived controllability; and entrepreneurial intention is best represented by three factors—choice intention, commitment to entrepreneurship, and nascent entrepreneurship. The findings indicated further that affective attitude and perceived self-efficacy are by far the strongest predictors of intention, thus highlighting the role of emotions in the entrepreneurial process. Our work revealed also that the relationship between commitment to entrepreneurship and nascent entrepreneurship is stronger in men than in women. Conceiving nascent entrepreneurship as a proxy for entrepreneurial behavior, this finding implies that gender is a moderator of the entrepreneurial intention-action translation. Despite its limitations, this study makes some important contributions and implications to the literature of entrepreneurship. These and future research suggestions are also discussed.
Validation of the English and simplified Mandarin versions of the Fear of Progression Questionnaire – Short Form in Chinese cancer survivors
Authors: Mahendran Rathi , Liu Jianlin , Kuparasundram Sangita , Griva Konstadina 
Published: January 2020

Abstract
Background
The fear of illness progression is common amongst those with chronic illnesses including cancers, and contributes to high psychological morbidity. Research in Asia on such fears however, is limited by a paucity of validated measurement instruments. Amongst the many available instruments, the Fear of Progression Questionnaire has a high quality rating, an important consideration in its selection. This study developed a simplified Mandarin version of the Fear of Progression Questionnaire – Short Form (FoP-Q-SF), and validated the English and Mandarin versions for use in Chinese populations.

Methods
The translation to a simplified Mandarin version was through a forward-backward translation with emphasis on conceptual and cultural equivalence. Cancer survivors (N = 341) completed a self-report questionnaire, the Fear of Progression Questionnaire – Short Form, other measures of fear of progression, depression, anxiety, and quality of life. Reliability and criterion validity were assessed, and the factor-structure was replicated with a confirmatory factor analysis.

Results
The Fear of Progression Questionnaire – Short Form demonstrated high internal and test-retest reliability. Criterion validity was also demonstrated through convergent, concurrent and discriminant validity. The factor structure was supported and replicated. The goodness-of-fit indices of the original model indicated some misfit, which could be adequately addressed by freeing five parameters in the error covariance matrix, without changing the one-factor structure.

Conclusions
The Fear of Progression Questionnaire – Short Form is a reliable and valid measure of fear of progression applicable to a mixed-cancer survivor population in Singapore. The simplified Mandarin version of the questionnaire will be useful in other parts of Asia and for Chinese migrants in the West, further extending the use of this questionnaire.
Movement behaviour of two social urticating caterpillars in opposite hemispheres
Authors: Uemura Mizuki , Perkins Lynda E. , Zalucki Myron P. , Battisti Andrea 
Published: January 2020

Abstract
Background
Investigating movement ecology of organisms has economic, societal, and conservation benefits. Larval movement of insects for example, plays many significant ecological roles, and with the expansion of the human population and development, encounters and conflicts with insects have increased. Urticating caterpillars are a health concern to people and animals, especially when they disperse in a gregarious and synchronised manner in areas frequented by humans. Ochrogaster lunifer and Thaumetopoea pityocampa from the southern and northern hemispheres respectively, are two geographically-isolated species of moth with similar gregarious urticating caterpillars that can outbreak causing defoliation and medical issues.

Methods
Each year from March to May, O. lunifer and T. pityocampa caterpillars leave their nesting sites and form head-to-tail processions on the ground in search of pupation sites. This pre-pupation procession behaviour and its associated risk of human contact with O. lunifer and T. pityocampa caterpillars were studied and compared in Australia and Italy, respectively. The distance, duration, orientation and response to visible light of the pre-pupation processions were studied in both species to determine general patterns.

Results
In the morning, O. lunifer and T. pityocampa processions travelled on average 40 and 16 m per day from the nest in 153 and 223 min respectively, in search for potential pupation sites. Ochrogaster lunifer pre-pupation processions travelled generally to the north or south when leaving the nest, as was their final orientation to the bivouac/pupation site. Whereas T. pityocampa processions had no preference in orientation. Ochrogaster lunifer and T. pityocampa pre-pupation processions travelled towards the darker and the lighter areas of the environment, respectively. During our observations, 27% of O. lunifer and 44% of T. pityocampa processions had contact with humans driving, cycling or walking.

Conclusions
The amount of human contact is surprising and alarming, because of the serious health implications they cause to humans and animals. The processionary dispersal on the ground risks further spread of urticating hairs that can be easily detached, and particular during inadvertent contact. Our limited sample size of T. pityocampa processions may benefit from more observations to make conclusive remarks on their pre-pupation behaviour. Understanding the movement behaviour of O. lunifer and T. pityocampa pre-pupation processions around populated areas is crucial for predicting exposure risk and application of management strategies.
Learning from the past, intervening in the present: the role of conservation science in the challenging restoration of the wall painting Marriage at Cana by Luca Longhi (Ravenna, Italy)
Authors: Fiorillo Flavia , Fiorentino Sara , Montanari Matteo , Roversi Monaco Camilla , Del Bianco Andrea , Vandini Mariangela 
Published: January 2020

Abstract
The paper discusses the case study of the Marriage at Cana, a sixteenth century wall painting located in Ravenna and executed by Luca Longhi. A multi-analytical approach based upon OM, SEM–EDS, μ-Raman, μ-FTIR and biological analyses was selected to investigate the painting technique and the state of preservation of the artwork, compromised by a severe alteration. Data demonstrated that the artwork was executed with a dry painting technique: a siccative oil was used as binder, while indigo, lead white, carbon black, ochres, vermilion and red lead were identified as pigments. Biological analyses clearly allowed identifying Eurotium halophilicum as the fungus responsible for the white patina compromising the painted surface and, according to this result, Biotin T was selected as the most effective biocide to stop the biological attack. The precarious conditions in which the painting was, attributable to previously performed interventions and to the conservation environment, laid the groundwork for a challenging restoration conducted in 2016. Scientific analyses better clarified the kind of materials employed in the execution on the artwork, as well as how the previous restoration was carried out; furthermore, analytical data methodologically supported phases of the intervention like cleaning, filling of the lacunae and pictorial retouching, as products were selected on the basis of their affinity to original materials and painting technique. This study will hopefully encourage reflections on how a synergic dialogue between conservation science and restoration can represent an important reference point for interventions to be conducted with scientific criteria and suitable methodology, in the light of the shared vision and common goal of transferring patrimony to future generations.
Interpreting forest diversity-productivity relationships: volume values, disturbance histories and alternative inferences
Authors: Sheil Douglas , Bongers Frans 
Published: January 2020

AbstractUnderstanding the relationship between stand-level tree diversity and productivity has the potential to inform the science and management of forests. History shows that plant diversity-productivity relationships are challenging to interpret—and this remains true for the study of forests using non-experimental field data. Here we highlight pitfalls regarding the analyses and interpretation of such studies. We examine three themes: 1) the nature and measurement of ecological productivity and related values; 2) the role of stand history and disturbance in explaining forest characteristics; and 3) the interpretation of any relationship. We show that volume production and true productivity are distinct, and neither is a demonstrated proxy for economic values. Many stand characteristics, including diversity, volume growth and productivity, vary intrinsically with succession and stand history. We should be characterising these relationships rather than ignoring or eliminating them. Failure to do so may lead to misleading conclusions. To illustrate, we examine the study which prompted our concerns —Liang et al. (Science 354:aaf8957, 2016)— which developed a sophisticated global analysis to infer a worldwide positive effect of biodiversity (tree species richness) on “forest productivity” (stand level wood volume production). Existing data should be able to address many of our concerns. Critical evaluations will improve understanding.
Benefits of temporary alcohol restriction: a feasibility randomized trial
Authors: Field Matt , Puddephatt Jo-Anne , Goodwin Laura , Owens Lynn , Reaves Danielle , Holmes John 
Published: January 2020

Abstract
Background
Participation in temporary alcohol abstinence campaigns such as ‘Dry January’ may prompt enduring reductions in alcohol consumption. A randomized controlled trial (RCT) is required to establish any long-term benefits or negative consequences of temporary abstinence. In the present study, we randomized heavy drinkers to complete or intermittent alcohol abstinence for 4 weeks, in order to evaluate the feasibility of conducting a large-scale RCT.

Methods
This was a mixed methods feasibility study in which we explored recruitment and retention to a randomized trial, compliance with alcohol abstinence instructions and barriers to compliance, and acceptability of study procedures (primary feasibility outcomes). A community sample of women aged between 40 and 60 who drank in excess of 28 alcohol units per week were randomized to abstain from alcohol for 4 weeks either completely or intermittently (at least four abstinent days per week). To monitor compliance, both groups provided regular breath samples on a cellular breathalyser. A subsample completed a semi-structured interview that probed barriers to compliance with abstinence instructions and acceptability of study procedures.

Results
Within 5 months, we recruited, screened and randomized 25 participants (20% of participants who responded to advertisements: 14 in the complete abstinence group, 11 in the intermittent abstinence group), 24 of whom were retained throughout the 28-day intervention period. Participants in both groups tended to comply with the instructions: the median number of breathalyser-verified abstinent days was 24 (IQR = 15.5–25.0; 86% of target) in the complete abstinence group versus 12 (IQR = 10–15; 75% of target) in the intermittent abstinence group. Semi-structured interviews identified some barriers to compliance and methodological issues that should be considered in future research. No adverse events were reported.

Conclusions
It is feasible to recruit heavy drinking women from community settings and randomize them to either complete or intermittent abstinence from alcohol for 4 weeks. The majority of participants were retained in the study and compliance with the abstinence instructions was good, albeit imperfect. A comprehensive RCT to compare temporary alcohol abstinence with other alcohol reduction strategies on long-term alcohol consumption is feasible. Findings from such a trial would inform implementation of alcohol campaigns and interventions.
Multi-objective optimization strategy for distribution network considering V2G-enabled electric vehicles in building integrated energy system
Authors: Huang Zhao , Fang Baling , Deng Jin 
Published: January 2020

AbstractBased on the large-scale penetration of electric vehicles (EV) into the building cluster, a multi-objective optimal strategy considering the coordinated dispatch of EV is proposed, for improving the safe and economical operation problems of distribution network. The system power loss and node voltage excursion can be effectively reduced, by taking measures of time-of-use (TOU) price mechanism bonded with the reactive compensation of energy storage devices. Firstly, the coordinate charging/discharging load model for EV has been established, to obtain a narrowed gap between load peak and valley. Next, a multi-objective optimization model of the distribution grid is also defined, and the active power loss and node voltage fluctuation are chosen to be the objective function. For improving the efficiency of optimization process, an advanced genetic algorithm associated with elite preservation policy is used. Finally, reactive compensation capacity supplied by capacitor banks is dynamically determined according to the varying building loads. The proposed strategy is demonstrated on the IEEE 33-node test case, and the simulation results show that the power supply pressure can be obviously relieved by introducing the coordinated charging/discharging behavior of EV; in the meantime, via reasonable planning of the compensation capacitor, the remarkably lower active power loss and voltage excursion can be realized, ensuring the safe and economical operation of the distribution system.