bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of high-flow nasal cannula therapy on mechanical ventilation duration in the pediatric intensive care unit
Authors: Choi Jaeyoung , Park Esther , Park Hyejeong , Kang Danbee , Yang Jeong Hoon , Kim Hyunsoo , Cho Juhee , Cho Joongbum 
Published: December 2024

Background
High-flow nasal cannula (HFNC) therapy has gained popularity in the pediatric intensive care unit (PICU). However, the nationwide effect of HFNC on mechanical ventilation duration has not been studied.

Methods
We retrospectively analyzed pediatric patients (28 days to 17 years old) admitted to tertiary ICUs for respiratory support from 2012 to 2019 using the Korean National Health Insurance database. Pre-/post-HFNC periods were defined as the 12 months before and after the application of HFNC in any hospital, respectively, allowing a 6-month transition period. Mechanical ventilation duration and ventilator-free days during these two periods were compared using a multivariable regression model.

Results
Using data from 46 hospitals, 4,705 and 4,864 respective pre-/post-HFNC period patients were evaluated. During the post-HFNC period, 14.8% of patients were treated by HFNC, and 67.1% were treated using invasive mechanical ventilation. In adjusted analysis, mechanical ventilation duration was reduced by 0.99 days (confidence interval [CI]: -1.86, -0.12). The duration was significantly reduced by 17.81 days (CI: -35.46, -0.16) among patients whose ventilation duration was longer than 28 days. In subgroup analysis, mechanical ventilation duration was reduced by 1.49 days (CI: -2.78, -0.19) in the overall surgical group and 6.71 days (CI: -11.71, - 1.71) in the neurologic subgroup. Ventilator-free days were increased only in the overall surgical group, by 0.31 days (CI: 0.01, 0.61).

Conclusions
Application of HFNC to PICU patients could reduce mechanical ventilation duration, especially in patients requiring prolonged mechanical ventilator support or in post-operative patients.
The Effect of Binahong Leaf Extract Emulsion (Anredera cordifolia) on Histopathological Description of Common Carotid Artery Study on Male Wistar (Rattus novergicus) Rats Induced by Diabetes Mellitus Using Streptozotocin
Authors: Fauzi Muhammad Iqbal , Pudjonarko Dwi , Indraswari Darmawati Ayu , Istiadi Hermawan , Wati Arinta Puspita 
Published: December 2024

Background: Diabetes mellitus (DM) is a chronic metabolic disease that can cause microvascular and macrovascular complications. The formation of superoxide (O2-) by dysfunctional mitochondria in diabetes has been recognised as a major driver of diabetic complications. Consequently, the utilisation of antioxidants may prove advantageous. The plant Andredera cordifolia contains flavonoids, which act as antioxidants.Objective : to investigate the effect of binahong leaf extract on the development of atherosclerosis in the carotid artery.Methods: The research employed a laboratory experimental method with a randomised post-test control group design. The research subjects were 15 Wistar rats (Rattus norvegicus). In this research, the extraction of the active compounds was achieved through a maceration process using 96% ethanol (1:3) and emulsification by the addition of sunflower oil, CMC, Span80 and Tween 20. The analysis of Anredera cordifolia extract content included the determination of flavonoid content and IC50. The intervention will be conducted for a period of 14 days. The rats were administered 1 ml of aquades per day, 45 mg/kg BW of metformin (K+), 200 mg/kg BW of EAC (P1), and 400 mg/kg BW of EAC (P2). The diabetic model was induced using a single dose of 50 mg/kgBW streptozotocin intraperitoneally. On the fourteenth day following the induction of treatment, blood glucose measurements were taken using the GOD-PAP method, and a histopathological examination of the common carotid artery was conducted using eosin haematoxylin staining at a magnification of 100-400x.Results: The total flavonoid content of binahong leaves is 1525 mg/100 g extract, while the IC50 value is 1.9 ppm. The results of the ANOVA indicate a statistically significant difference between the fasting blood glucose levels of the two groups (p < 0.05). The post hoc test demonstrated that a 400 mg/kgBW dose can result in a reduction in glucose levels to 305.75 mg/dl, with a p-value of 0.001 (p < 0.05). The Mann-Whitney test revealed a statistically significant difference among the groups (p < 0.05) for the inhibition of atherosclerosis in the common carotid artery. Conclusion: A significant difference was observed in the administration of 400 mg/kgBB binahong leaf emulsion extract in comparison to a negative control group, with regard to the histopathological picture of atherosclerosis of the common carotid artery
Clove Flower Extract (Syzygium aromaticum) enhance Wound Healing Time, Bacterial Count, and IL 10 Levels in Methicillin Resistant Staphylococcus aureus infected Rats
Authors: Muttaqien Rizal Arief, , Lestari Endang Sri , Prajoko Yan Wisnu , Susilaningsih Neni 
Published: December 2024

To determine the effect of clove flower extract on the healing time of incision wounds, bacterial count and IL-10 levels in rats infected with MRSA.Method. Experimental study with a post-test-only control group design in rats that were given incisions on their backs. Random allocation was carried out to divide the Sprague Dawley rats into 6 groups (@5 rats). Healing time was assessed based on the length of days, the bacterial count was examined from the blood and then counted by culture using nutrient agar. IL-10 levels were examined from the venous blood of rats and then measured using an ELISA kit assessed by a certified microbiologist. Data were analyzed and processed using the One Way Anova - Post Hoc hypothesis test.Results. The bacterial count in the clove flower extract group was lower than the group without antibiotics and there was no difference compared to the group given antibiotics. IL-10 levels in the group given clove flower extract were lower when compared to the group given antibiotics. The wound healing time in the clove flower extract group was faster when compared to the group with or without antibiotics.Conclusion. Clove flower extract enhancewound healing in MRSA-infected rats.
THE EFFECT OF COMBINATION FOSFOMYCIN AND SAMBILOTO (Andrographis paniculata) LEAF EXTRACT ON THE LEUKOCYTES COUNT, NITRITE LEVELS, AND LACTOFERRIN LEVELS IN WISTAR RATS (Rattus norvegicus) URINARY TRACT INFECTION MODEL
Authors: Sutriono Sutriono , Lestari Endang Sri , Agung Nugroho Eriawan , Nindita Yora , Addin Sofyan Rais 
Published: December 2024

Background: Fosfomycin is the first-line of antibiotic for urinary tract infection (UTI). To prevent antibiotic resistance, antibiotics and herbal medicines combination was developed. Studies have shown that Andrographis paniculata has antimicrobial and anti-inflammatory agent.Objective: To investigate the effect of A. paniculata extract for treating UTI in animal modelMethods: Using post test only control group design, thirty females Rattus norvegicus rats were induced by 1 cc transurethral inoculation of E. coli and then randomly grouped into negative control (NC) received no treatment, positive control (PC) that had 54 mg fosfomycin, and treatment groups which were divided into T1 (A. paniculata 100 mg/kgBW), T2 (A. paniculata 200 mg/kgBW), T3 (fosfomycin 54 mg with A. paniculata 100 mg/kgBW), T4 (fosfomycin 54 mg with A. paniculata 200 mg/kgBW). Urinary samples were utilized to count leukocytes under microscope, nitrite levels with a dipstick, and lactoferrin using ELISA.Results: Combination of fosfomycin and A. paniculata led to a reduction in the number of leukocytes and nitrite levels compared to the single therapy group, particularly in T4 group (p<0.001). There were no significant differences in lactoferrin levels among all study groups (p>0.05).Conclusion: Combination of A. paniculata with fosfomycin resulted in a more pronounced reduction in the number of leukocytes and nitrite levels compared to single therapy, while lactoferrin levels were unaffected.TRANSLATE with x EnglishArabicHebrewPolishBulgarianHindiPortugueseCatalanHmong DawRomanianChinese SimplifiedHungarianRussianChinese TraditionalIndonesianSlovakCzechItalianSlovenianDanishJapaneseSpanishDutchKlingonSwedishEnglishKoreanThaiEstonianLatvianTurkishFinnishLithuanianUkrainianFrenchMalayUrduGermanMalteseVietnameseGreekNorwegianWelshHaitian CreolePersian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster PortalBack//
The different serum albumin assays influence calcium status in haemodialysis patients: a comparative study against free calcium as a reference method
Authors: Eisa Osama , Dafaalla Mohammed , Wright Mark , Faisal Muhammad , Stuart Kevin , Jassam Nuthar 
Published: December 2024

Abstract

Objectives
Accurate assessment of calcium levels is crucial for optimal management of regular Haemodialysis (HD) patients. Different calcium adjustment equations and albumin methods; including bromocresol purple (BCP) and bromocresol green (BCG) assays are employed by laboratories, which cause considerable discrepancies between reported results. The aim of this study is to assess the influence of albumin assays on calcium status in stable haemodialysis patients against free calcium (fCa) as a gold standard test.

Methods
103 paired serum and fCa samples were collected from a cohort of stable HD patients. Albumin levels were measured by either the BCP or BCG method, and samples were also analysed for the total calcium (T.Ca), phosphate, bicarbonate, and pH levels. The performance of BCG-based and BCP-based adjusted calcium equations was compared using Z-scores scatter plots, intraclass correlation coefficient and Cohen Kappa statistic, with fCa being the reference standard.

Results
Unadjusted T.Ca achieved a 70 % overall classification agreement with fCa and identified 61 % of the “true” hypocalcaemic samples. Adjusted calcium concentrations, calculated by either BCP- or BCG-based equation, were poor predictors of fCa; with more than 50 % of the hypocalcaemic samples being misclassified as normocalcaemic. Notably, both equations misclassified the calcium status in 5 (4.9 %) patients with severe hypocalcaemia (i.e., potentially requiring calcium infusion) as mild hypocalcaemia.

Conclusions
Our study showed evidence of hidden hypocalcaemia being missed by the current practice of using adjusted calcium in HD patients. Therefore, we recommend abandoning the adjustment procedure in samples from stable HD patients in favour of fCa measurement.
FONTES, HISTÓRIA E MEMÓRIA DO CENTRO MUNICIPAL DE EDUCAÇÃO INFANTIL TIO PATINHAS DE MANDAGUARI / PR (1950-2000)
Authors: Sena Lioti Cláudia , Marlene Stentzler Márcia 
Published: December 2024

Este artigo objetiva analisar a história da criação e existência do Centro Municipal de Educação Infantil (CMEI)
Tio Patinhas de Mandaguari/PR, entretecida à concepção de infância e organização socioeducacional brasileira. A instituição educacional foi criada no ano de 1950, logo após a fundação do município de Mandaguari/PR e permanece até os dias atuais sendo referencial para a educação infantil na cidade. A pesquisa foi organizada com base em fontes documentais disponíveis em arquivos, bem como respostas a
questionários, entremeadas a pesquisas já desenvolvidas na área. Desvelaram-se aspectos da história e memória deste CMEI em sua relação com a concepção de infância, as transformações sociais e a legislação educacional.
EXPERIÊNCIAS COM O CURRÍCULO CULTURAL DA EDUCAÇÃO FÍSICA NA EDUCAÇÃO INFANTIL
Authors: De Carvalho Duarte Leonardo , Garcia Neira Marcos 
Published: December 2024

Este estudo teve como objetivo analisar experiências documentadas com o currículo cultural da Educação Física na Educação Infantil. Trata-se de pesquisa bibliográfica onde produziu-se um gesto descritivo-analítico com quatro capítulos de livro, duas dissertações, uma tese e 16 relatos de prática disponíveis no repositório do GPEF/USP. Os resultados evidenciam experiências próximas de proposições contemporâneas dos estudos sociais da infância que posicionam bebês e crianças pequenas como produtoras de cultura, sujeitos sociais com direitos que podem/devem ser escutados e ter suas vozes consideradas na sociedade e nas práticas educacionais.
Politics, Technology, and Interdisciplinarity at the Centro Latinoamericano de Altos Estudios Musicales (CLAEM): Rafael Aponte-Ledée’s Presagio de pájaros muertos (1966)
Authors: Torres-Rivera Noel 
Published: December 2024

Abstract
Through a close examination of the composition, premiere, and subsequent performances of Rafael Aponte-Ledée’s mixed-media piece Presagio de pájaros muertos (1966), this article interrogates the entanglement between sound, politics, technology, and interdisciplinarity at one of Latin America’s most influential music institutions in the twentieth century: the Centro Latinoamericano de Altos Estudios Musicales (CLAEM). Moreover, the article situates musical avant-garde and experimental practices at CLAEM in the context of the Center’s material and ideological interactions with the Centro de Artes Visuales (CAV) and the Centro de Experimentación Audiovisual (CEA). Drawing on unprocessed and scattered archival materials, oral histories, and music analysis, the article first addresses Presagio’s text in relation to both local and international politics, thereby positioning it within the ever-growing interest in conceiving political artworks across the Instituto Torcuato Di Tella (ITDT)—the umbrella institution for each of the three centers—and the artistic milieu of Buenos Aires more broadly. Proposing a synchronic assessment of the history of CLAEM’s Electronic Music Laboratory, the article secondarily analyzes ways in which electronic music composition was conceptualized, particularly in its relation to political activism.
Comparative analysis of conventional and bifaical solar cells under various illumination conditions
Authors: Aliev R. , Komilov M. , Aliev S. , Gulomova I. 
Published: December 2024

In this work, through a detailed analysis of the mechanisms of photon absorption, photogeneration processes and the efficiency of nonequilibrium charge carriers’ collection under conditions of rear and double-sided illumination, the initial physical parameters of the internal layers and the design of double-sided sensitive solar cells with n+-p junction on the front side has been studied. The modern numerical simulation method was used to study the solar cells. Models of silicon solar cells (SC) contains p+-p-n+ structure with separating n+-p-junction near the frontal (upper) surface. Increasing the doping concentration in the p-region notably enhances the steepness of the I-V curve, indicative of improved quality of the solar cell and p-n junction. Specifically, an optimal doping concentration of 1015 cm⁻³ yields the highest efficiency, demonstrating the critical role of doping concentration in performance optimization. Furthermore, variations in doping concentration exert differential impacts on key parameters. Notably, open-circuit voltage, fill factor, efficiency, maximum output power, and serial resistivity exhibit distinct responses to changes in doping concentration. For instance, an increase in doping concentration from 1013 cm⁻³ to 1015 cm⁻³ results in notable improvements across these parameters, highlighting the significance of precise doping control in enhancing solar cell performance. When, photoelectric parameters of conventional and double side sensitive solar cells are compared, it has been found that the short circuit current and open circuit voltage of double side solar cell are 2 times and 18 mv greater than those of conventional solar cell.
Оптичні властивості стекол As2S3:Ag
Authors: Кришеник В.М. , Погодін А.І. , Філеп М.Й. , Войнарович І.М. , Поп М.М. , Рубіш В.В. , Гомоннай О.В. 
Published: December 2024

У статті описано результати вивчення впливу рівня внесення срібла в новосинтезованих стеклах Agx(As2S3)1-x (0 ≤ x ≤ 0.2) на край оптичного поглинання, ширину забороненої зони і дисперсію показника заломлення у видимому і ближньому інфрачервоному діапазонах. Отримані експериментальні залежності проаналізовано з допомогою одноосциляторної моделі Вемпла–Ді Доменіко. Показано, що зі збільшенням вмісту Ag у склі оптична ширина забороненої зони стає меншою, як і енергія одиночного осцилятора, натомість енергія дисперсії зростає, а ступінь іонності зв’язку залишається практично незмінним.
Paisanos, familiares y comerciantes a crédito. Las redes comerciales de los árabes en el interior de Colombia, 1899-1940
Authors: Díaz Rico Jhojan Alejandro 
Published: December 2024

Objetivo: reconstruir las redes comerciales que los inmigrantes árabes conformaron entre el Caribe colombiano y Cundinamarca, Tolima y Huila desde finales del siglo XIX, cuando comenzaron a llegar al país, hasta finales de la década de 1930, momento en el que comenzaba a decrecer su actividad comercial. Metodología: con información de registros notariales de Bogotá, Barranquilla y Cartagena, manifiestos de importación, prensa y directorios comerciales, se utiliza el análisis de redes sociales para reconstruir la estructura de las redes y así identificar los actores que las conformaron, los tipos de vínculos que se establecieron y la manera en que operaron. Originalidad: la historiografía de los árabes en Colombia se ha concentrado en su accionar comercial en la Costa Caribe, por lo que este trabajo representa el primer intento por analizar la conformación de sus redes comerciales en el centro del país. Conclusiones: esta investigación señala que el auge comercial posibilitado por las economías de exportación de principios del siglo XX permitió que los árabes se establecieran en el centro del país y conformaran una red comercial que se estructuró a partir de relaciones crediticias basadas en el parentesco y el paisanaje, las cuales permitieron su expansión comercial a lo largo de los tres departamentos.
Mortalidad en pacientes con tuberculosis multidrogoresistente en un hospital de tercer nivel de Lima, Perú
Authors: Altamirano-Arauco Milenka , Casanova-Mendoza Aldo Renato , Salas-López Juan Antonio , Llanos-Tejada Félix Konrad , Vargas-Ponce Kenneth Grenis 
Published: December 2024

Introducción. En los últimos años se ha reportado un aumento en el número de casos de tuberculosis (TB) multidrogoresistente (MDR) a nivel mundial. Esto implica un incremento en las tasas de mortalidad debido a que el tratamiento de la TB-MDR es complejo y a la presencia de diferentes factores de riesgo en estos pacientes.
Objetivo. Determinar los factores de riesgo de mortalidad en pacientes con TB-MDR atendidos en el Servicio de Neumología del Hospital Nacional Dos de Mayo (Lima, Perú) entre 2014 y 2018.
Materiales y métodos. Estudio retrospectivo de casos y controles realizado en 305 pacientes con TB-MDR hospitalizados entre 2014 y 2018 (casos: 62; controles: 243). Los casos se definieron como aquellos pacientes que fallecieron. Los datos de las variables de interés se obtuvieron de las historias clínicas. Se realizó un análisis bivariado y uno multivariado (modelo de regresión logística) mediante el cálculo de odds ratio (crudos y ajustados) para determinar la asociación entre las variables consideradas y la mortalidad.
Resultados. El promedio de edad fue 48.2±19.4 años. En el análisis multivariado, tener diabetes mellitus (ORa: 8.580, IC95%: 1.805-40.785), tener antecedente de TB (ORa: 4.923, IC95%: 1.474-16.446), la presencia de tabaquismo (ORa: 12.189, IC95%: 3.047-48.759), la presencia de consumo activo de sustancias psicoactivas (ORa: 9.428, IC95%: 2.737-32.482) y estar desnutrido (ORa: 6.652, IC95%: 1.432-30.888) se asociaron con un mayor riesgo de mortalidad por TB-MDR.
Conclusiones. En el presente estudio se identificaron varios factores de riesgo de mortalidad en pacientes con TB-MDR. En el Hospital Nacional Dos de Mayo, así como en otros hospitales de Lima que atiendan estos pacientes, se deben implementar estrategias para el manejo adecuado de la TB-MDR, en particular en pacientes con los factores de riesgo de mortalidad aquí identificados.
Uso de toxina botulínica como adyuvante prequirúrgico en reparación de hernia incisional realizada con técnica de Rives-Stoppa en un paciente pediátrico: reporte de caso
Authors: Quintero-Garzón Paula Andrea , Torres-Pulido Jose Ricardo , Escobar Fernando Augusto 
Published: December 2024

Introducción. Si bien la hernia incisional es una condición poco frecuente en pacientes pediátricos, es relevante por sus posibles complicaciones e impacto estético y funcional.
Presentación del caso. Niño de 14 años con antecedente de apendicitis aguda con peritonitis generalizada que en julio de 2020 requirió múltiples intervenciones quirúrgicas y quien dos meses después fue reingresado al servicio de urgencias de un hospital de segundo nivel del departamento de Boyacá (Colombia) por obstrucción intestinal, donde, a pesar de recibir manejo conservador, no se observó mejoría, por lo cual fue remitido a un hospital universitario de Boyacá, donde, luego de 7 días de manejo médico, fue llevado a laparoscopia exploratoria en la que se realizó lisis de adherencias abdominales y resección de un segmento del intestino. En octubre de 2020 fue llevado nuevamente al servicio de urgencias por obstrucción intestinal, requiriendo de nuevo manejo quirúrgico (lisis de múltiples adherencias peritoneales y adherencias abdominales en el íleon proximal). Durante el segundo control postoperatorio, 6 meses después, se evidenció hernia incisional de 10cm de diámetro. Dado el gran tamaño de la hernia y sus características, se decidió reparar quirúrgicamente con técnica de Rives-Stoppa con aplicación de toxina botulínica de tipo A como adyuvante prequirúrgico, logrando recuperación de la anatomía de la pared abdominal sin complicaciones.
Conclusión. Si bien actualmente no hay un tratamiento de elección para la reparación de hernias incisionales en pacientes pediátricos, la técnica de Rives-Stoppa representa una opción terapéutica eficaz y segura. Igualmente, la toxina botulínica de tipo A demostró ser un adyuvante prequirúrgico efectivo para la reducción del riesgo de complicaciones.
Leucoencefalopatía multifocal progresiva causada por el virus John Cunningham. Reporte de un caso
Authors: Muñoz-Mora Dario Fernando , Lozano-Fernández Víctor Hugo , Uribe-Caldón Angie Katherine 
Published: December 2024

Introducción. La leucoencefalopatía multifocal progresiva (LMP) es una enfermedad desmielinizante y multifactorial que es causada por el virus John Cunningham (VJC) y que ocurre principalmente en personas con VIH/sida.
Presentación del caso. Hombre de 28 años con VIH (sin tratamiento antirretroviral [TAR]) y antecedente de sarcoma de Kaposi diseminado quien en mayo de 2021 asistió al servicio de urgencias de un hospital de tercer nivel de atención de Popayán (Colombia) por cefalea, náuseas, emesis, astenia, adinamia e insomnio ocasional. Durante la primera hospitalización, y con base en los hallazgos imagenológicos y del cultivo del líquido cefalorraquídeo (LCR), fue diagnosticado con criptococosis meníngea, siendo dado de alta a los 28 días por respuesta favorable al tratamiento de mantenimiento (fluconazol vía oral), con indicación de iniciar TAR. Dos meses después, durante una nueva hospitalización y con base en las manifestaciones clínicas y los hallazgos imagenológicos y del cultivo de LCR, se sospechó LMP, por lo que se solicitó prueba de PCR para VJC en LCR, con lo cual se confirmó el diagnóstico. En los siguientes meses el paciente presentó un progresivo deterioro físico y cognitivo y finalmente falleció en agosto de 2022.
Conclusiones. El caso aquí presentado es de gran pertinencia para la evaluación de pacientes con diagnóstico de VIH y compromiso significativo de su sistema inmune, pues amplía el espectro de infecciones oportunistas que se deben tener en cuenta en estos pacientes; además, brinda las herramientas necesarias para esclarecer las manifestaciones clínicas y el abordaje diagnóstico de la LMP en presencia de VIH.