bluuebunny/crossref_metadata_2025_split huggingface dataset:
OnabotulinumtoxinA (botulinum toxin type A) for the treatment of Japanese patients with overactive bladder and urinary incontinence: Results of single‐dose treatment from a phase III, randomized, double‐blind, placebo‐controlled trial (interim analysis)
Authors: Yokoyama Osamu , Honda Masashi , Yamanishi Tomonori , Sekiguchi Yuki , Fujii Kenji , Nakayama Takashi , Mogi Takao 
Published: January 2020

ObjectiveTo evaluate the efficacy and safety of onabotulinumtoxinA (botulinum toxin type A) 100 U in patients with overactive bladder and urinary incontinence.MethodsThis was a phase III, randomized, double‐blind, placebo‐controlled trial in Japanese patients who were inadequately managed with overactive bladder medications (anticholinergics and/or β3‐adrenergic receptor agonists). Eligible patients were randomized 1:1 to receive a single dose of either onabotulinumtoxinA or placebo into the detrusor muscle (n = 124 each). The primary end‐point was the change in the number of daily urinary incontinence episodes at week 12 from baseline. Secondary end‐points included volume voided per micturition, other symptomatic measures (urinary urgency incontinence, micturition, urgency and nocturia) and patient‐reported outcomes.ResultsIn the onabotulinumtoxinA group, there was a significantly greater decrease from baseline in the mean number of daily urinary incontinence episodes compared with the placebo group (2.16; P < 0.001), and significantly greater improvement for all secondary end‐points (P < 0.05). Urinary tract infection, dysuria, urinary retention and post‐void residual urine volume increased represented adverse events occurring at a higher rate in the onabotulinumtoxinA group. The majority of these were mild or moderate in severity.ConclusionsStatistically significant and clinically relevant improvements in symptoms and patient‐reported outcomes, and tolerability were seen in patients with overactive bladder and urinary incontinence who had been inadequately managed with overactive bladder medications after using onabotulinumtoxinA.
Interleukin‐23 pathway at the enthesis: The emerging story of enthesitis in spondyloarthropathy
Authors: Bridgewood Charlie , Sharif Kassem , Sherlock Jonathan , Watad Abdulla , McGonagle Dennis 
Published: January 2020

AbstractThe inflammatory disorders collectively termed the seronegative spondyloarthropathies (SpA) include ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis, the arthritis associated with inflammatory bowel disease including Crohn's disease and ulcerative colitis, the arthritis related to anterior uveitis, and finally, somewhat controversially Behcet's disease. All of these diseases are associated with SNPs in the IL‐23R or the interleukin‐23 (IL‐23) cytokine itself and related downstream signaling JAK pathway genes and the interleukin‐17 (IL‐17) pathway. In rheumatoid arthritis, the target of the immune response is the synovium but the SpA disorders target the tendon, ligament, and joint capsule skeletal anchorage points that are termed entheses. The discovery that IL‐23R–expressing cells were ensconced in healthy murine enthesis, and other extraskeletal anchorage points including the aortic root and the ciliary body of the eye and that systemic overexpression of IL‐23 resulted in a severe experimental SpA, confirmed a fundamentally different immunobiology to rheumatoid arthritis. Recently, IL‐23R–expressing myeloid cells and various innate and adaptive T cells that produce IL‐17 family cytokines have also been described in the human enthesis. Blockade of IL‐23 pathway with either anti‐p40 or anti‐p19 subunits has resulted in some spectacular therapeutic successes in psoriasis and PsA including improvement in enthesitis in the peripheral skeleton but has failed to demonstrate efficacy in AS that is largely a spinal polyenthesitis. Herein, we discuss the known biology of IL‐23 at the human enthesis and highlight the remarkable emerging story of this unique skeletal tissue.
Nurses' intention to stay: The impact of perceived organizational support, job control and job satisfaction
Authors: Li Xiaoyu , Zhang Yaqing , Yan Dexiu , Wen Fule , Zhang Yuanyuan 
Published: January 2020

AbstractAimTo propose a theoretical model of intention to stay (ITS) and examine the effects of perceived organizational support, job control and job satisfaction on ITS.DesignCross‐sectional multicentre survey.MethodsThe survey was conducted from January 2017‒July 2017 and comprised 3,240 clinical nurses from nine tertiary hospitals in eastern, central and western China, with 2,352 effective responses. Structural equation modelling was used to analyse the relationship between ITS and its correlative factors.ResultsThe hypothesized model was supported. Job control, perceived organizational support and job satisfaction significantly and directly affected nurses' ITS. Furthermore, job control and perceived organizational support showed indirect effects on ITS, which was mediated by job satisfaction. Perceived organizational support could positively influence job control to have a further impact on job satisfaction and ITS.ConclusionBased on a large sample of Chinese tertiary hospital nurses, this study proposed and verified a theoretical model of nurses' ITS, revealing that organization characteristics, work characteristics and affective response to work can have an impact on ITS.ImpactThis study was the first to examine the relationships among perceived organizational support, job control, job satisfaction and ITS, enriching the theoretical model of ITS. Nurse managers can improve nurses' ITS by enhancing their perceived organizational support, job control and job satisfaction.
Palaeoenvironmental setting of MojokertoHomo erectus, the palynological expressions of Pleistocene marine deltas, open grasslands and volcanic mountains in East Java
Authors: Morley Robert J. , Morley Harsanti P. , Zaim Yahdi , Huffman O. Frank 
Published: January 2020

AbstractAimTo determine the vegetation and landscape experienced byHomo erectuspopulations which first inhabited Java.LocationPerning, near Mojokerto, East Java, the 1936 discovery locality of a fossil child's skull widely attributed toH. erectus, and laterally equivalent sediments at Jetis.TaxonTerrestrial, mangrove and aquatic plants.MethodsA comprehensive suite of samples was collected at close spacing through a coastal sedimentary succession analysed concurrently for its depositional origins. The section traversed particularly informative marine, delta front and delta plain deposits, including the bonebed in which theH. erectuswas discovered.ResultsRich palynomorph recovery indicative of mangroves was obtained in the mud‐dominated marine Mollusk Member II at the base of the analysed section. The overlying deltaic strata are characterized by grass pollen and phytoliths, while still retaining mangrove and wetland signals in key samples near the level of theH. erectusbed.Main conclusionThe vertical stratigraphic series of facies in the Perning and adjacent Jetis sections indicates a landscape with four potentialHomohabitats: muddy deltas with widespreadNypaswamps; a poorly vegetated sandy delta; extensive open savanna grasslands in the lowlands up river of the delta; and volcanoes in the upper reaches of the catchment with perhumid montane podocarp and broad‐leaf forests and probable open fire‐climaxCasuarina junghuhnianaforest. Palynological data support an Early Pleistocene geological age for MojokertoH. erectusat about 1.43 Myr.
Additional benefits of nonconventional modalities of cardiac resynchronization therapy using His bundle pacing
Authors: Coluccia Giovanni , Vitale Elena , Corallo Serena , Aste Milena , Odaglia Federica , Donateo Paolo , Oddone Daniele , Brignole Michele 
Published: January 2020

AbstractIntroductionDyssynchrony persists in many patients despite cardiac resynchronization therapy (CRT). Aim of this proof‐of‐concept study was to achieve better CRT, with a QRS approximating the normal width and axis, by using His bundle pacing (HBP) and nonconventional pacing configurations.Methods and ResultsIn 20 patients with CRT indications, we performed an acute intrapatient comparison between conventional biventricular (CONV) and three nonconventional pacing modalities: HBP alone, His bundle, and coronary sinus pacing (HBP + CS), and HBP + CS plus right ventricular pacing (TRIPLE). Electrical dyssynchrony was assessed by means of QRS width and axis; “quasi‐normal” axis meant an R/S ratio ≥ 1 in leads I and V6 and ≤1 in V1. Mechanical dyssynchrony was assessed by speckle tracking echocardiography. QRS width was 153 ± 18 ms on CONV, shortened to 137 ± 16  ms on HBP + CS (P = .001) and to 130 ± 14 ms on TRIPLE (P = .001), while it remained unchanged on HBP (159 ± 32 ms; P = .17). The rate of patients with “quasi‐normal” axis was 5% on CONV, and increased to 90% on HBP (P = .0001), to 63% on HBP + CS (P = .001), and to 44% on TRIPLE (P = .02). On radial strain analysis, the time‐to‐peak difference between anteroseptal and posterolateral segments was 143 ± 116 ms on CONV, shortened to 121 ± 127 ms on HBP (P = .79), to 67 ± 70 ms on HBP + CS (P = .02), and to 76 ± 55 ms on TRIPLE (P = .05). On discharge, HBP was chosen in 15% of patients, HBP + CS in 55%, and TRIPLE in 30%; CONV was never chosen.ConclusionNonconventional modalities of CRT provide acute additional electrical and mechanical resynchronization. An interpatient variability exists.
High‐fat diet‐induced dysbiosis mediates MCP‐1/CCR2 axis‐dependent M2 macrophage polarization and promotes intestinal adenoma‐adenocarcinoma sequence
Authors: Liu Tianyu , Guo Zixuan , Song Xueli , Liu Li , Dong Wenxiao , Wang Sinan , Xu Mengque , Yang Cheng , Wang Bangmao , Cao Hailong 
Published: January 2020

AbstractHigh‐fat diet (HFD) is a well‐known risk factor for gut microbiota dysbiosis and colorectal cancer (CRC). However, evidence relating HFD, gut microbiota and carcinogenesis is limited. Our study aimed to demonstrate that HFD‐induced gut dysbiosis promoted intestinal adenoma‐adenocarcinoma sequence. In clinical study, we found that HFD increased the incidence of advanced colorectal neoplasia (AN). The expression of monocyte chemoattractant protein 1 (MCP‐1), CC chemokine receptor 2 (CCR2) and CD163 in CRC patients with HFD was significantly higher than that in CRC patients with normal diet. When it comes to the Apcmin/+ mice, HFD consumption could induce gut dysbiosis and promote intestinal carcinogenesis, accompanying with activation of MCP‐1/CCR2 axis that recruited and polarized M2 tumour‐associated macrophages. Interestingly, transfer of faecal microbiota from HFD‐fed mice to another batch of Apcmin/+ mice in the absence of HFD could also enhance carcinogenesis without significant body weight gain and induced MCP‐1/CCR2 axis activation. HFD‐induced dysbiosis could also be transmitted. Meanwhile, antibiotics cocktail treatment was sufficient to inhibit HFD‐induced carcinogenesis, indicating the vital role of dysbiosis in cancer development. Conclusively, these data indicated that HFD‐induced dysbiosis accelerated intestinal adenoma‐adenocarcinoma sequence through activation of MCP‐1/CCR2 axis, which would provide new insight into better understanding of the mechanisms and prevention for HFD‐related CRC.
Recognition of different Longjing fresh tea varieties using hyperspectral imaging technology and chemometrics
Authors: Yan Lei , Pang Lei , Wang Hua , Xiao Jiang 
Published: January 2020

AbstractHyperspectral imaging technology was applied to detect and recognize six different varieties of Longjing fresh tea. The data contained image and spectral information at 370–1042 nm; color and texture features were the foci of the image research. Spectral pre‐processing was performed by multiplicative scatter correction (MSC) and standard normal variate (SNV), and then, we selected the corresponding position variable and vegetation indexes as spectral features. Representative features including the most information were chose by principal component analysis (PCA). A novel back propagation (BP) neural network, with a self‐generated number of hidden layer neurons, was proposed. Using spectral features, image features, and spectral image fusion features as input, three fresh tea recognition models were established: the improved BP neural network, traditional BP neural network, and support vector machine (SVM). Results suggested that the improved BP neural network could promote performance of the model, especially for the spectral pre‐processed data. Mixed‐feature models did better than individual feature models, with 100% accuracy of the predictive set. This study shows that hyperspectral imaging technology can be a potential rapid and nondestructive approach to identify different varieties of Longjing fresh teas.Practical applicationsThis article introduced application of hyperspectral imaging technology to identify Longjing fresh tea of different origins and varieties. Samples were analyzed using spectral and image characteristics. We provided a basis for full utilization of tea characteristics. At the same time, an improved BP neural network, with less calculation complexity and workload than the traditional BP neural network, was proposed. In summary, we outlined a convenient and reliable method for differentiation of Longjing fresh teas. Furthermore, we established a theoretical foundation for development of portable instruments to be used in similar studies.
Effects of smelling amniotic fluid on preterm infant's pain and stress during peripheral cannulation: A randomized controlled trial
Authors: Alemdar Dilek Küçük , Tüfekci Fatma Güdücü 
Published: January 2020

AbstractAimTo investigate the effect of smelling amniotic fluid on preterm infants' pain and stress caused by peripheral cannulation.MethodsThis was a randomized controlled trial. The study sample consisted of 80 preterm infants meeting the case selection criteria and infants were randomly assigned to each group. However, in addition to the infants excluded from the study, total number of the infants in all the groups was 61. Infants in the amniotic fluid group smelled amniotic fluid for 15 min before, during, and after the application of peripheral cannulation while those in the control group received routine care during the procedure. The Premature Infant Pain Profile was used to assess their pain levels, and salivary cortisol analysis was performed to evaluate stress levels.ResultsPreterm infants in the amniotic fluid and control groups had similar baseline characteristics. However, the pain levels of infants in the amniotic fluid group were significantly lower than of those in the control group during and after the procedure. After the procedure, cortisol levels of the infants in the amniotic fluid group were lower than of those in the control group, although this difference was not significant.ConclusionThe intervention of smelling amniotic fluid is a practice that can be used for reducing pain and stress of preterm infants during peripheral cannulation.
Effects of smartphone application education combined with hands‐on practice in breast self‐examination on junior nursing students in South Korea
Authors: Kang So Ra , Shin Hyewon , Lee JungMin , Kim Shin‐Jeong 
Published: January 2020

AbstractBackgroundBreast self‐examination is a convenient and effective way to detect breast abnormalities. Based on Dale's Cone of Experience theory, we hypothesized that the combination of a smartphone application with hands‐on practice would have a greater impact than using a smartphone application alone. The purpose of this study was to compare the effects of different educational methods on (a) knowledge, (b) attitudes, (c) skills, and (d) students' satisfaction with the learning methods.MethodsWe conducted a pre‐ and post‐test quasi‐experimental design and developed a smartphone application using a video clip. One experimental group received smartphone‐based education, another group received smartphone‐based education combined with hands‐on practice, and the control group received a one‐time classroom lecture. We administered a pre‐test, provided intervention, and conducted a post‐test.ResultsAmong the three groups, the knowledge and attitude of the experimental groups were significantly higher than that of the control group. In addition, the group using the combination of the smartphone application and hands‐on practice showed the highest score changes in skills and satisfaction with the learning methods.ConclusionsSmartphone application use combined with hands‐on practice could be an effective education method for breast self‐examination.
Correcting abnormalities in miR‐124/PTPN1 signaling rescues tau pathology in Alzheimer’s disease
Authors: Hou Tong‐Yao , Zhou Yang , Zhu Ling‐Shuang , Wang Xiong , Pang Pei , Wang Ding‐Qi , Liuyang Zhen‐Yu , Man Hengye , Lu Youming , Zhu Ling‐Qiang , Liu Dan 
Published: January 2020

AbstractMicroRNAs have been implicated in diverse physiological and pathological processes. We previously reported that aberrant microRNA‐124 (miR‐124)/non‐receptor–type protein phosphatase 1 (PTPN1) signaling plays an important role in the synaptic disorders associated with Alzheimer's disease (AD). In this study, we further investigated the potential role of miR‐124/PTPN1 in the tau pathology of AD. We first treated the mice with intra‐hippocampal stereotactic injections. Then, we used quantitative real‐time reverse transcription PCR (qRT‐PCR) to detect the expression of microRNAs. Western blotting was used to measure the level of PTPN1, the level of tau protein, the phosphorylation of tau at AD‐related sites, and alterations in the activity of glycogen synthase kinase 3β (GSK‐3β) and protein phosphatase 2 (PP2A). Immunohistochemistry was also used to detect changes in tau phosphorylation levels at AD‐related sites and somadendritic aggregation. Soluble and insoluble tau protein was separated by 70% formic acid (FA) extraction to examine tau solubility. Finally, behavioral experiments (including the Morris water maze, fear conditioning, and elevated plus maze) were performed to examine learning and memory ability and emotion‐related behavior. We found that artificially replicating the abnormalities in miR‐124/PTPN1 signaling induced AD‐like tau pathology in the hippocampus of wild‐type mice, including hyperphosphorylation at multiple sites, insolubility and somadendritic aggregation, as well as learning/memory deficits. We also found that disruption of miR‐124/PTPN1 signaling was caused by the loss of RE1‐silencing transcription factor protein, which can be initiated by Aβ insults or oxidative stress, as observed in the brains of P301S mice. Correcting the deregulation of miR‐124/PTPN1 signaling rescued the tau pathology and learning/memory impairments in the P301S mice. We also found that miR‐124/PTPN1 abnormalities induced activation of glycogen synthase kinase 3 (GSK‐3) and inactivation of protein phosphatase 2A (PP2A) by promoting tyrosine phosphorylation, implicating an imbalance in tau kinase/phosphatase. Thus, targeting the miR‐124/PTPN1 signaling pathway is a promising therapeutic strategy for AD.
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microRNA‐9‐5p alleviates blood–brain barrier damage and neuroinflammation after traumatic brain injury
Authors: Wu Jingchuan , He Junchi , Tian Xiaocui , Luo Yuetao , Zhong Jianjun , Zhang Hongrong , Li Hui , Cen Bo , Jiang Tao , Sun Xiaochuan 
Published: January 2020

AbstractThe level of microRNA‐9‐5p (miRNA‐9‐5p) in brain tissues is significantly changed after traumatic brain injury (TBI). However, the effect of miRNA‐9‐5p for brain function in TBI has not been elucidated. In this study, a controlled cortical impact model was used to induce TBI in Sprague–Dawley rats, and an oxygen glucose deprivation model was used to mimic the pathological state in vitro. Brain microvascular endothelial cells (BMECs) and astrocytes were extracted from immature Sprague–Dawley rats and cocultured to reconstruct blood–brain barrier (BBB) in vitro. The results show that the level of miRNA‐9‐5p was significantly increased in brain tissues after TBI, and up‐regulation of miRNA9‐5p contributed to the recovery of neurological function. Up‐regulation of miRNA‐9‐5p with miRNA agomir may significantly alleviate apoptosis, neuroinflammation, and BBB damage in rats after TBI. Moreover, a dual luciferase reporter assay confirmed that miRNA‐9‐5p is a post‐transcriptional modulator of Ptch‐1. In in vitro experiments, the results confirmed that up‐regulation of miRNA‐9‐5p with miRNA mimic alleviates cellular apoptosis, inflammatory response, and BBB damage mainly by inhibiting Ptch‐1. In addition, we found that the activation of Hedgehog pathway was accompanied by inhibition of NF‐κB/MMP‐9 pathway in the BMECs treated with miRNA‐9‐5p mimic. Taken together, these results indicate that up‐regulation of miRNA‐9‐5p alleviates BBB damage and neuroinflammatory responses by activating the Hedgehog pathway and inhibiting NF‐κB/MMP‐9 pathway, which promotes the recovery of neurological function after TBI.
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Effects of anhydrous gel with TriHex peptides on healing after hybrid laser resurfacing
Authors: Nelson Aislyn M. , Ortiz Arisa E. 
Published: January 2020

AbstractBackgroundHybrid fractional laser skin resurfacing is a procedure that combines fractional nonablative and ablative wavelengths to improve photoaging. The postoperative period involves overt skin swelling, redness, and roughness.ObjectiveA single‐center, randomized trial was performed to compare the effect of a standard Skincare regimen, with and without an anhydrous gel with TriHex peptides (a proprietary tripeptide and hexapeptide blend), on recovery after hybrid laser resurfacing of the face.MethodsFive subjects were assigned to a split‐face protocol. Use of the skin regimen began approximately 2 weeks before the hybrid laser resurfacing and ended 7 days after. Subjects were evaluated by a physician for postprocedural healing. Additionally, the subjects were photographed and completed surveys to assess postprocedural healing and overall preference for Skincare regimen.ResultsBased on physician assessment, mean redness on postoperative days 1 and 4 and mean roughness on the postoperative days 3 and 4 were significantly (P < .05) improved on the side of the face using the anhydrous gel with TriHex peptides compared with the side using a standard skin regimen. Based on subject assessment, 4 out of 5 subjects thought that their skin and complexion appeared better on the anhydrous gel–treated side and preferred the Skincare regimen with the gel.ConclusionsThese data suggest that using the anhydrous gel with TriHex peptides before and after hybrid fractional laser skin resurfacing can minimize the postoperative redness and roughness that are typical and expected for this procedure.