bluuebunny/crossref_metadata_2025_split huggingface dataset:
Descripción de líneas celulares sanguíneas de pacientes con blastos provenientes de cinco ciudades de Colombia. Serie de casos
Authors: Cruz-Rubio Shirley Gigiola , Márquez-Benítez Yusselfy , Lancheros Adriana María , Mosquera-Heredia Mabely Juliana , Oliveros-Barros Julieth Esteher 
Published: August 2020

Introducción: las leucemias constituyen un grupo complejo de hemopatías que por su etiología, patogenia y mortalidad, son consideradas un problema de salud pública. Su detección temprana permite la remisión oportuna para la confirmación del diagnóstico y el inicio del tratamiento.
Objetivo: describir la celularidad sanguínea de pacientes con presencia de blastos en sangre periférica, provenientes de cinco ciudades de Colombia durante el año 2017.
Métodos: estudio tipo descriptivo de serie de casos. A partir de hemogramas y sus respectivos extendidos de sangre periférica, se analizó cualitativa y cuantitativamente las células sanguíneas de los pacientes con blastos que cumplieron con los criterios de inclusión.
Resultados: fueron incluidos 39 pacientes con presencia de blastos de novo en sangre periférica procedentes de Cúcuta 48,7 %, Valledupar 33,3 %, Tunja 10,3 %, Socorro 5,1 % y Villavicencio 2,6 %. El 100 % eran afiliados al istema general de seguridad social en salud en donde predominó el sexo femenino con el 54 %, la edad promedio para las mujeres fue de 32,5 años y para los hombres fue de 44,2 años. El 76 % de los pacientes presentó leucocitosis de moderada a grave y 69,2 % neutropenia. El 95 % presentó anemia, 51 % hipocromía y 38 % microcitos. El 74 % presentó trombocitopenia y 15 % macroplaquetas.
Conclusiones: los hallazgos concuerdan con lo reportado por la literatura en relación con el predominio de la nfermedad de acuerdo con la edad y el sexo. La anemia, trombocitopenia y neutropenia, se mantienen como característica constante en los pacientes con leucemia.
Borderland (poem)
Authors: LeBon-Herb Patricia 
Published: August 2020

The poem ‘Borderland’ is inspired by more than 24,000 miles of fieldwork that Patricia LeBon Herb conducted in the borderlands between the US and Canada together with her partner Guntram Herb. Their work seeks to document the challenges of native nations divided the US-Canada border (www.border-rites.org). Patricia is an enrolled member of the Sault Ste Marie Tribe of Chippewa Indians.
Dialogue on the Impact of Coronavirus on Research and Publishing: Monday 22nd June 2020
Authors: Graham Laura , Raj Senthorun , Munro Vanessa , Westmarland Nicole , Wheatle Se-shauna , Sanders Teela , Russell Yvette , Maine Alexander 
Published: August 2020

<span>This roundtable took place via Microsoft Teams on Monday 22</span><sup>nd</sup><span> June 2020 to discuss the impact of COVID-19 on Research and Publishing in the UK</span>
Application of the Hart-Devlin debate to the ideas and arguments raised in ‘Legalising assisted dying would be a failure of collective human memory and imagination’
Authors: Hurwood Jessica 
Published: August 2020

The Hart-Devlin debate centres upon the strongly contested issue of whether or not the law should enforce morality. The debate between these two figures was sparked by the Wolfenden Report of 1957, which concluded that due to the importance of individual freedom, ‘there must remain a realm of private morality which is, in brief and crude terms, not the law’s business’. The progression of our society into a more liberal entity has led to the argument that Hart, widely regarded as the twentieth century’s greatest British legal philosopher, has ultimately superseded Devlin in this debate. Therefore, this essay shall re-examine each side of the debate in light of the changing legal landscape, specifically with reference to the public opinion on legalising euthanasia. The examination will seek to determine whether Hart’s liberal approach has in fact prevailed, or whether society is more inclined to accept the more conservative approach advocated by Devlin.
Peran Kepolisian Resort Kediri dalam penanggulangan tindak pidana perjudian
Authors: Sulaiman Muhammad Aldy 
Published: August 2020

Pada dasarnya para pelaku perjudian sudah banyak yang diseret ke depan pengadilan untuk mempertanggung jawabkan perbuatannya. Namun dalam praktiknya pelaku perjudian tidak menyadari dan tetap mengulangi lagi perbuatannya bahkan dilakukan secara terbuka dan lebih berani. Tujuan penelitian ini adalah untuk mengetahui peran kepolisian resort Kediri dalam penanggulangan tindak pidana perjudian. Metode yang digunakan penelitian ini menggunakan metode pendekatan kualitatif, yaitu suatu tata cara penelitian yang menghasilkan data diskriptif-analitis Hasil penelitian membuktikan peran Polres Kediri dalam mengatasi tindak pidana dengan upaya non-pidana dan pidana. Faktor-faktor yang menjadi penghambat dan pendorong dalam penanggulangan yang ikut serta dalam perjudian, demi masyarakat, adalah faktor penghambat yang terdiri dari kontrol sosial yang kurang maksimal, faktor ekonomi, tingkat masyarakat yang rendah, respons yang rendah dari masyarakat terhadap sosialisasi atau penyuluhan yang dilakukan oleh polisi, penegak hukum kurang bertanya dalam bertindak. Sementara itu, faktor penggeraknya adalah anggota Bhabinkamtibmas yang terus meningkatkan kemampuan mereka, jaminan keamanan oleh petugas perlindungan masyarakat sehingga suasana tertib dan nyaman tetap terjaga, pengembangan potensi yang ada di masyarakat lingkungan setempat agar menjadi kekuatan untuk memelihara situasi aman dan mencegah gangguan yang meresahkan masyarakat.
Allanites in the Sin Quyen IOCG deposit, North Vietnam
Authors: Nguyen Dinh Chau , Pieczonka Jadwiga , Piestrzynski Adam , Le Khanh Phon , Duong Van Hao 
Published: August 2020

Abstract: Allanite minerals are the principal host of REEs in the Sin Quyen, Iron Oxide Copper Gold (IOCG) type deposit. The geochemical characteristics of these minerals are discussed in this work. The studied allanites have an unstable concentration of all major elements, such as REE (14-27 wt%), Ca (9-16 wt%), Al (8-19 wt%), Si (26-34 wt%) and Fe (12-21 wt%). Two different varieties of these minerals are documented, the older with higher REE concentrations ranging from 20 to 27 wt%, and younger with lower total REE concentration ranging from 14 to 19 wt%, which occur as a rim surrounding the older. Differences between the two groups of allanites are documented by Raman spectra and optical properties. The WDS chemical composition indicate that the allanites belong to the Ce-La-ferriallanite family, with low ƩHREE with an average of 0.21 wt.%. This work also supports the estimated timing of the deposit development focusing on detailed petrological study, and documented chemical composition of allanites confirmed by simplified statistical analysis.
Temperature 355ºC which was calculated using value of δ34S isotopes is interpreted as a temperature of the second crystallization stage of allanite group. The pressure of crystallization solution was calculated and is ranging from 0.98 to 5.88 MPa.
Strategi Komunitas Petani Jambu Madu Deli Dalam Pemberdayaan Masyarakat di Desa Kuryokalangan Kecamatan Gabus Kabupaten Pati
Authors: Wahida Emilia Nurul 
Published: August 2020

<p><strong>Abstrak </strong></p><p>Tulisan ini akan membicarakan tentang strategi komunitas kelompok petani jambu madu deli di desa Kuryokalangan mengenai pemberdayaan masyarakat terutama di bidang perekonomian. Melihat adanya pengangguran di wilayah ini, komunitas petani jambu madu deli berinisiatif untuk memberdayakan masyarakat. Kesadaran untuk melakukan pemberdayaan di respon cukup baik oleh warga setempat, namun terkadang ada pula yang meremehkan. Komunitas jambu ini sudah mulai berkembang dan mengalami penaikan sedikit demi sedikit. Pemberdayaan ini bertujuan untuk meningkatkan perekonomian masyarakat khususnya para pemuda yang belum memiliki pekerjaan, ibu rumah tangga. Tak hanya sampai disitu, dengan adanya pemberdayaan ini diharapkan dapat meningkatkan pengetahuan dan keahlian petani dalam meningkatkan hasil dari tanaman jambu tersebut.</p><p>Penelitian ini bersifat kualitatif deskriptif, data penelitian diperoleh menggunakan wawancara, dokumentasi. Perlu adanya kerjasama antara komunitas petani jambu madu deli dengan pemerintah desa setempat.</p><p>Hasil penelitian dari karya tulis ini menjelaskan bahwa strategi pemberdayaan masyarakat yang dilakukan oleh komunitas ini adalah pemberdayaan berdasarkan teori PAR (Participatory Action Research), dengan teori ini diharapkan dapat berjalan dengan seoptimal mungkin.</p><p>Kata kunci : pemberdayaan masyarakat, komunitas petani jambu madu deli, ekonomi.</p><p><strong><em>Abstract</em></strong></p><p><em>This article wil discuss the comunity strategy of the Deli Guava Honey farmers group in the Kuryokalangan village, Gabus sub district Pati Regency. Regarding community empowerment especially in the economic field. Seeing unemployment in this area, the Deli guava honey community initiative to empower the community awareness to empower people is quite good in response to loval resident. But sometimes there is also an underestimation the guava honey community began ti develop and experience a gradual increase. This empowerment aims to improve the community eceonomy, especially young people who do not have jobs, housewives not only that with this empowerment increase the insight, ability, and expertise of farmers in increasing crop yields. </em></p><p><em>This research is descriptive qualitative, research dats obtained using interviews, documentation. There is a need for cooperation between the community of Deli guava hiney farmers and the local village government</em></p><p><em>Research results from this paper, explain that the strategy of community is empowerment based on Particpatory Action Research theory and is expected to run as optimal as possible. </em></p><p><em>Keyword : community development, deli honey guava farmers community, the economy.</em></p>
Peran Masjid dalam Pemberdayaan Ekonomi dan Sosial Umat di Tengah Pandemi Covid-19, Studi Kasus: Masjid Al-Mizan Griya Tahunan Indah Jepara.
Authors: Ilmi Firda Wasi’atul , Amin Alhakim Muhammad Ilham 
Published: August 2020

<p><strong>Abstract</strong></p><p>This study aims to analyze the role of mosques in economic and social empowerment during social distancing or movement restrictions due to the spread of the Coronavirus Disease pandemic (Covid-19). Covid-19 has become a problem for people in all fields, especially in the health, social and economic fields. The role of the mosque in empowering the social economy can provide assistance to the surrounding community. The method used in this study uses the literature study method. Efforts to empower the social economy of the people in the midst of a pandemic include: providing assistance to the surrounding community in the form of food supplies. The results of this study indicate that the role of the mosque is needed in economic and social empowerment of the people in the midst of the Covid-19 pandemic. From the results of these studies, economic empowerment activities can be carried out by providing food packages to the people who are affected by the corona virus (Covid-19).</p><pre>Keywords: The Role of the Mosque, Empowerment of the Social Economy, Pandemic Covid-19</pre><p> </p><p align="center"> Abstrak</p><p>Penelitian ini bertujuan untuk menganalisis peran masjid dalam pemberdayaan ekonomi dan sosial pada masa social distancing atau pembatasan gerak akibat adanya penyebaran pandemi Coronavirus Disease (Covid-19). Covid-19 ini menjadi problem masyarakat di segala bidang terutama dalam bidang kesehatan, soial, maupun ekonomi. Peran masjid dalam pemberdayaan ekonomi sosial dapat memberi bantuan bagi masyarakat sekitar. Metode yang digunakan dalam penelitian ini menggunakan metode studi kepustakaan. Upaya pemberdayaan ekonomi sosial umat di tengah pandemi meliputi: pemberian bantuan kepada masyarakat sekitar berupa sembako. Hasil dari penelitian ini menunjukkan bahwa peran masjid sangat dibutuhkan dalam pemberdayaan ekonomi dan juga sosial umat ditengah pandemi Covid-19. Dari hasil penelitian tersebut maka kegiatan pemberdayaan ekonomi dapat dilakukan dengan memberikan bantuan paket sembako kepada masayarakat yang sedang terdampak virus corona (Covid-19).</p><p>Kata Kunci: Peran Masjid, Pemberdayaan Ekonomi Sosial, Pandemi Covid-19</p>
Kolaborasi Pemerintahan Desa dan Masyarakat Dalam Penanggulangan Pada Dampak Pandemi Covid 19 di Desa Karang
Authors: Yulianti Riska , Khalimatussa’diyah Nur 
Published: August 2020

<p align="center"><strong>ABSTRAK</strong></p><p><em>Tujuan dalam penulisan ini adalah menjelaskan bahwa kolaborasi masyarakat pada penanggulangan dan pecegahan pada pandemic corona virus disease 19 ( covid 19) di Desa Karang itu sangat penting. Dalam penanggulangan dan pencegahan da</em><em>m</em><em>pak pandemi covid 19 ini pemerintahan desa dan tokoh</em><em>-</em><em> tokoh desa ikut unggul dalam kegiatan aksi tersebut. Pada kolaborasi penanggulangan ini menggunakan metode kualitatif dan metode PAR yang di lakukan dengan cara membentuk progam aksi pratisipasi masyarakat yang bertujuan untuk mengubah kondisi sosial dari pandemic covid tersebut. Kolaborasi yang di lakukan masyarakat tersebut meru</em><em>p</em><em>akan salah satu kunci utama dalam menjalankan keberhasilan dalam pencegahan dan juga penyebaran wabah Covid-19 ini. Sosial Distancing ataupun Physical distancing merupakan salah satu kegiatan utama yang harus diterapkan guna untuk memotong rantai dari penyebaran virus corona atau biasa disebut dengan Covid-19. Sebagian masyarakat pun sadar maka masyarakat akan mengikuti mekanisme dalam pembatasan sosial ini, tetapi masih ada sebagian juga yang belum berpartisipasi dalam aksi penanggulangan penyebaran covid 19.Tulisan ini mengkasi Kolaborasi masyrakat dalam pencegahan penyebaran virus pandemic Covid-19 di Desa Karang. Penanganan penyebaran pandemic virus Covid-19 ini dapat terlaksanakan dengan baik jika masyarakat ikut serta mengikuti himbauan yang di buat oleh pemerintah untuk selalu melakukan kegiatan- kegiatannya salah satunya melakukan jaga jarak dan tetap tinggal di rumah (stay at home). </em></p><div><p><em>Kata Kunci : Kolaborasi Masyarakat, Penanggulangan Pandemi Covid 19, Pemerintahan Desa</em></p></div>
Peningkatan Kesehatan Masyarakat Dampak Dari Pembakaran Genteng di Desa Ngembalrejo, Kecamatan Bae, Kabupaten Kudus
Authors: Wahyuni Sinta 
Published: August 2020

<p align="center"><strong>Abstrak</strong></p><p>Industri pembuatan genteng merupakan salah satu mata pencaharian masyarakat Desa Ngembalrejo, hampir sebagian besar masyarakat di desa ini bekerja sebagai pembuat genteng. Hingga menjadi ciri khas bagi desa Ngembarejo sendiri yang terkenal dengan desa pembuat genteng dengan kualitas yang bagus. Pembuatan genteng ini sebenarnya sudah ada di daerah ini cukup lama, dapat di katakan warisan para leluhur. Para pembuat genteng ini selalu mengutamakan kualitas dari genteng yang mereka buat, hal ini terbukti dengan mereka masih menggunakan pembakaran secara manual meskipun saat ini perkembangan teknologi sudah sangat canggih. Tak lepas dari itu, ada pula dampak negatif yang dapat mengganggu kesehatan masyarakat yang tinggal di sekitar tempat pembuatan genteng. Asap dari pembakaran genteng yang sampai saat ini belum dapat diatasi, asap tebal hitam dan pekat menjadi pemandangan setiap hari bagi masyarakat desa Ngembalrejo. Keadaan ini menjadikan menurunnya kualitas udara di Desa Ngembalrejo, namun situasi ini belum juga dapat membuat masyarakat sadar akan pencemaran udara yang terjadi. Mereka tetap menjalankan kehidupan mereka dengan baik-baik saja, padahal tanpa sadar mereka menghirup udara yang tidak sehat setiap harinya.</p><p align="center"><strong><em>Abstrak</em></strong></p><strong><em> </em></strong><em>Tile making industry is one of the jobs of the people in Ngembalrejo Village, most of the Ngembarejo Village community work as tile makers. To become a characterisic for the village of Ngembalrejo it self which is famous for its tile making village with good quality. This tile making has actually been around in this area for quite a long time, it can be said as the legacy of the ancestors. These tile makers always prioritize the quality of the tile’s they mae, this is proven by their still using manual combustion even though the current technological development has been vety sophisticated. It cannot be separated from that there are also egative impact that can interfere with the health of the people who live around the roof tile. Smoke from the burning of tiles which until now has not been able to be overcome, thick black and thick smoke becomes a daily sight for the people of the Ngembalrejo Vilage. This situation makes the air quality decline in the village og Ngembalrejo, but this situation has not been able to make the community aware of the air pollution that occurs. They still run their lives well, even though they unconsciously breathe un healthy air every day.</em>
Quantitative Response of Healthy Muscle Following the Induction of Capsaicin: An Exploratory Randomized Controlled Trial
Authors: Evans Valerie , Behr Michael , Masani Kei , Kumbhare Dinesh 
Published: August 2020

Abstract
Background: Myofascial pain syndrome (MPS) is a prevalent chronic pain disorder primarily characterized by myofascial trigger points (MTrP). There is limited knowledge on the pathophysiology and mechanisms underlying MTrP and its development. Research has previously demonstrated the identification of MTrPs using ultrasound and vibrationsonoelastography, although there is some contradictory evidence regarding if MTrPs present as hyper or hypoechoic regions. Electromyography (EMG) investigations of MTrP have demonstrated that MTrP are usually located proximal to innervation zones where the peak surface EMG signals are obtained from. Central sensitization has been proposed as the primary mechanism underlying MTrP development. Central sensitization is associated withhyperexcitability of neuronal responses to normal or noxious stimuli. There is a need for a study that measures ultrasound image textural changes and motor unit activity responses in the muscle following sensitization. The purpose of this study is to determine whether sensitizing healthy muscle using capsaicin induces a regional change in image texture variables within the specific and surrounding muscles, as well as the motor unit frequency and amplitude changes that accompany them. This is an exploratory trial that aims to provide preliminary evidence on whether central sensitization is a direct cause of taut band and MTrP development.Methods: Ethical approval was obtained from the University Health Network (UHN)Research Ethics Board. This proposed study is a single centered, factorial, randomized placebo-controlled trial with two independent variables, depth of capsaicin application and dose of capsaicin, for a total of six treatment arms and three control treatment groups. Discussion: This will be the first study that assesses the B-mode ultrasound image texture of induced sensitized muscles, and will provide more evidence on muscle motor unit activity and regional changes of central sensitization. Findings from this study may support one of few hypotheses proposed delineating the involvement of central sensitization in the development of trigger points.Trial Registration: Name: National Institutes of Health ClinicalTrials.gov.Identifier: NCT03944889Date of Registration: May 07 2019URL: https://clinicaltrials.gov/ct2/show/NCT03944889
Implantation of Impella CP left ventricular assist device under the guidance of three-dimensional intracardiac echocardiography.
Authors: Yastrebov Konstantin , Brunel Laurencie , Williams Zoe , Wise Innes , Burrows Christopher , Paterson Hugh , Bannon Paul 
Published: August 2020

Abstract
Impella CP is a percutaneously inserted left ventricular assist device indicated for temporary mechanical cardiac support during high risk percutaneous coronary interventions and for cardiogenic shock. The potential application of Impella has become particularly relevant during the current COVID-19 pandemic, for patients with acute severe heart failure complicating viral illness. Standard implantation of the Impella CP is performed under fluoroscopic guidance. Positioning of the Impella CP can be confirmed with transthoracic or transoesophageal echocardiography. We describe an alternative approach to guide intracardiac implantation of the Impella CP using two-dimensional and three-dimensional intracardiac echocardiography. This new technique can be useful in selected groups of patients when fluoroscopy, transthoracic and transoesophageal echocardiography is deemed inapplicable or limited for epidemiological or clinical reasons. Intracardiac three-dimensional echocardiography is a feasible alternative to the traditional techniques for implantation of an Impella CP device but careful consideration must be given to the potential limitations and complications of this technique.
Evaluation of 3D Heads up ophthalmic surgery from the perspective of surgeons and postgraduate trainees
Authors: Cheng Teck Chee , Yahya Maliha Farah Nurhazirah , Naffi Ainal Adlin Mohd , Othman Othmaliza , Tang Seng Fai , Yong Meng Hsien , Rahim Wan Haslina Wan Abdul , Mustapha Mushawiahti , Hamzah Jemaima Che , Md Norshamsiah , Bastion Mae-Lynn Catherine 
Published: August 2020

Abstract
The authors have withdrawn this preprint due to author disagreement.
Hepatocyte high-mobility group box 1 protects against steatosis and cellular stress during high fat diet feeding
Authors: Lin Minjie , Long Jungke , Li Wenbo , Yang Chenxuan , Loughran Patricia , O’Doherty Robert , Billiar Timothy R. , Deng Meihong , Scott Melanie J. 
Published: August 2020

Abstract
Background: Circulating high-mobility group box 1 (HMGB1) plays important roles in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Intracellular HMGB1 is critical for the biology of hepatocytes. However, the intracellular role of HMGB1 in hepatocellular steatosis is unknown. Therefore, we aimed to investigate the role of hepatocyte-specific HMGB1 (HC-HMGB1) in development of hepatic steatosis. Methods: Wild type (WT) C57BL/6 and HC-HMGB1-/- mice were fed high-fat diet (HFD) or low-fat diet (LFD) for up to 16 weeks. Results: As expected, HMGB1 translocated from nuclear into cytoplasm and released into circulation after HFD treatment. HC-HMGB1 deficiency significantly reduced circulating HMGB1, suggesting that hepatocyte is a major source of circulating HMGB1 during NAFLD. Unexpectedly, HC-HMGB1 deficiency promoted rapid weight gain with enhanced hepatic fat deposition compared with WT at as early as 4 weeks after HFD treatment. Furthermore, there was no difference between WT and HC-HMGB1-/- mice in glucose tolerance, energy expenditure, liver damage or systemic inflammation. Interestingly, hepatic gene expression related to free fatty acid (FFA) β-oxidation was significantly down-regulated in HC-HMGB1-/- mice compared with WT, and endoplasmic reticulum (ER) stress markers were significantly higher in livers of HC-HMGB1-/- mice. In vitro experiments using primary mouse hepatocytes showed absence of HMGB1 increased FFA-induced intracellular lipid accumulation, accompanied by increased ER-stress, significant downregulation of FFA β-oxidation, and reduced oxidative phosphorylation. Conclusions: Our findings suggest that hepatocyte HMGB1 protects against dysregulated lipid metabolism via maintenance of β-oxidation and prevention of ER stress. This represents a novel mechanism for HMGB1-regulation of hepatocellular steatosis, and suggests that stabilizing HMGB1 in hepatocytes may be effective strategies for prevention and treatment of NAFLD.