bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Benefits of Participation in Community-Based Running and Walking Events: A Cross-Sectional Survey of Parkrun Participants
Authors: Quirk Helen , Bullas Alice , Haake Steve , Goyder Elizabeth , Graney Mike , Wellington Chrissie , Copeland Robert , Reece Lindsey , Stevinson Clare 
Published: December 2020

Abstract
Background: Whilst the benefits of physical activity for health and wellbeing are recognised, population levels of activity remain low. Significant inequalities exist, with socioeconomically disadvantaged populations being less physically active and less likely to participate in community events. We investigated the perceived benefits from participation in a weekly running/walking event by those living in the most socioeconomically deprived areas and doing the least physical activity.Methods: A cross-sectional online survey was emailed to 2,318,135 parkrun participants in the UK. Demographic and self-reported data was collected on life satisfaction, happiness, health status, physical activity, motives, and the perceived benefits of parkrun. Motivation, health status and benefits were compared for groups defined by level of physical activity at parkrun registration and residential Index of Multiple Deprivation.Results: 60,000 completed surveys were received (2.7% of those contacted). Respondents were more recently registered with parkrun (3.1 v. 3.5 years) and had a higher frequency of participation than non-respondents (14.5 v. 3.7 parkruns per year). Those who were inactive at registration and from socioeconomically deprived areas reported lower happiness, lower life satisfaction and poorer health than the full sample. They were more likely to want to improve their physical health, rather than get fit or lose weight. Of those reporting less than one bout of activity a week at registration, 88% (87% in the most socioeconomically deprived areas) increased their physical activity level and 52% (65% in the most socioeconomically deprived areas) reported improvements to overall health behaviours. Previously inactive respondents from the most socioeconomically deprived areas reported greater improvements to fitness (93% v. 89%), physical health (90% v. 85%), happiness (83% v. 79%) and mental health (76% v. 69%).Conclusion: The least active respondents from the most socioeconomically deprived areas reported changes to their activity levels and benefits to their health and wellbeing since participating in parkrun. Whilst the challenge of identifying how community initiatives like parkrun can better engage with the least active and most socioeconomically deprived remains, if this can be achieved, then such interventions can have a critical public health role in addressing inequalities in benefits associated with recreational physical activity.
Interaction Effects of Diabetes and Hypertension on Cardio-Cerebrovascular Diseases: A Cross-Sectional Study
Authors: Wang Zhehui , Yang Tubao , Fu Hanlin 
Published: December 2020

Abstract
Background It is still not clear whether there exsist interaction effects of diabetes and hypertension on cardio-cerebrovascular diseases. We can not ignore it in order to prevent the incidence and progress of cardio-cerebrovascular diseases considering the high prevalence of diabetes and hypertension in the world.Methods A cross-sectional study with a multistage stratified random sampling method was conducted among people aged 18 years or older in Changsha City, Hunan Province. A multivariate logistic regression model was performed to analyze the association between diabetes complicated with hypertension and cardio-cerebrovascular diseases. The multiplicative interaction effect was evaluated by including the product term of hypertension and diabetes in the model after adjusting for age, sex, smoking, drinking, physical exercise, and body mass index. The relative excess risk ratio (RERI), attribution percentage (AP), synergy index (SI) and 95% confidence interval (CI) were calculated by the Excel calculation table compiled by Andersson to evaluate the additive interaction effects between hypertension and diabetes on cardio-cerebrovascular diseases.Results A total of 14422 participants were recruited. The prevalence of cardio-cerebrovascular diseases in the non-diabetes and non-hypertension, diabetes, hypertension, and diabetes and hypertension combination groups was 3.7%, 12.1%, 21.2% and 31.4%, respectively. The RERI, AP and SI of diabetes combined with hypertension on cardiovascular diseases were 1.92 (95% CI: -2.67 - 6.50), 0.23 (95% CI: -0.22 - 0.68) and 1.34 (95% CI: 0.69 - 2.62), respectively.Conclusions The prevalence of cardio-cerebrovascular diseases in diabetes complicated with hypertension was higher than that in any single condition. However, no interaction effects between diabetes and hypertension were found on the prevalence of cardio-cerebrovascular diseases, indicating that the high prevalence may be due to the simple superposition of the two variables.
Community Based Case Control Study on Effect of Nutrition Education Intervention on Nutritional Status and Contributing Factors Among Under Five Children In Pastoralist And Agro-Pastoralist Community of Somali Region, Eastern Ethiopia.
Authors: Guled Rashid Abdi , Mamat Nik Mazlan , Belachew Tefera , Bakar Wan Azdie Mohd Abu , Assefa Nega 
Published: December 2020

Abstract
Background: Undernutrition is most common public health problem in developing world. It is responsible for more than three million global deaths of under five children every year. Severe wasting and stunting are the major contributors of this problems. Hence, this study was designed to document the effect of nutrition education intervention (NEI) on nutritional status of the children in pastoralist and agro-pastoralist community of Somali regional state, Eastern Ethiopia.Methods: A group randomized controlled trial was carried out among 404 paired child to mothers/caregivers in two phases. A chi-square for categorical variables, t-test and for continuous variables were used. In addition, World Health Organization (WHO) AnthroPlus software were also used.Results: After NEI this has shown statistically significant improvement, in all three types of malnutrition compared to control. The malnutrition prevalence has been significantly decreased within the group from baseline to post intervention; wasting (19% to 9.4%, p = 0.005), underweight (18.5% to 7.4%, p= 0.029), and stunting (31.2% to 21.7%, p= 0.001). Whereas, the control group showed no significant difference (p >0.05) in all three types. The overall mean Z-score difference of the difference (DOD) of wasting and underweight between groups from pre and post intervention were shown better off, compared to control group, with mean DOD wasting of (-0.738, p <0.001) and underweight of (-0.615, p <0.001). But, this was not seen in stunting (-0.239, p >0.05).Conclusion: The NEI using behaviour change communication (BCC) showed promising outcome, and need to be further scaled up and adapted to other districts in the zone or other areas in the region.
Modeling the Effect of Age on Quantiles of the Incubation Period Distribution of COVID-19
Authors: Liu Xiaohui , Wang Lei , Ma Xiansi , Wang Jiewen , Wu Liwen 
Published: December 2020

Abstract
Background: Since the ﬁrst case of pneumonia with unknown etiology was identiﬁed in Wuhan, Hubei province in China in December 2019, the novel coronavirus pneumonia has placed a serious impact on many aspects of the world. Note that the incubation period distribution plays important roles in prevention and control eﬀorts of COVID-19. This study aimed to investigate the conditional distribution of the incubation period of COVID-19 on the age of infected cases, and estimate its corresponding quantiles from information of 2172 conﬁrmed cases from 29 provinces outside Hubei in China.Methods: We collected data including the infection dates, onset dates, and ages of the conﬁrmed cases from the websites of the centres of disease control, or the daily public reports through February 16th, 2020. A maximum likelihood method was developed to account for the biased sampling issue of the data as the epidemic was still ongoing at the time of collecting data. Results: Based on the collected data, we found that the conditional quantiles of the incubation period distribution of COVID-19 varies over ages. In detail, the high conditional quantiles of people in the middle age group are shorter than those of others. We estimated that the 0.95-th quantile related to people in the age group 23∼55 is less than 15 days. Conclusions: Observing that the conditional quantiles vary over ages, we may take more precise measures for people of diﬀerent ages. For example, we may consider carrying out an age-dependent quarantine duration, rather than a uniform 14-days quarantine, in practice. Remarkably, we may need to extend the current quarantine duration for people aged 0 ∼ 22 and over 55 because the related 0.95-th quantiles are much greater than 14 days.
Spatial Analysis of the Tuberculosis Cure in Primary Care in Rio de Janeiro, Brazil
Authors: Junior José Carlos Prado , Medronho Roberto de Andrade 
Published: December 2020

Abstract
Background: Tuberculosis (TB) presents a high burden of disease and is considered a global emergency by the World Health Organization (WHO), consisting of the most important cause of death from infectious disease in adults. It is related directly to access to health services and socioeconomic factors. Primary health care provides greater linking people to health services and greater medication adherence in some chronic diseases. Also, it provides supervised treatment and the search for more effective contacts. Objective: This paper aims to compare the tuberculosis cure among the areas covered and not covered by the family health teams from 2012 to 2014. Methods: A cross-sectional study was carried out in Rio de Janeiro. The variables were obtained from the Notifiable Diseases Information System for Tuberculosis (SINAN-TB) and the socioeconomic variables from the 2010 national census. The socioeconomic variables were selected from the multivariate analysis using principal factors analysis techniques. For the spatial analysis was used a generalized additive model (GAM). Results: Association was found between TB cure and education, alcoholism, contacts search, serology for HIV and the elderly. People with family health coverage between 35 and 41 months had 1,64 more chance of cure when compared to people without coverage (95% CI 1.07 to 2.51). Conclusion: From the spatial analysis, it was possible to identify areas with less chance of cure for tuberculosis in the municipality.
An Assessment of Provisions of Noncommunicable Disease Services on Health Promotion, Prevention and Control at Primary Health Care: A Case Study from Two Divisions of Bangladesh
Authors: Pinki Sadia Sobhan , Noor Irfan Nowroze , Amin Bayzid , Islam Md. Ziaul , Riaz Baizid Khoorshid 
Published: December 2020

Abstract
BackgroundAlthough evidence suggests that cardiorespiratory fitness is the most important component associated with future health, little is known of how it is associated with multiple other physical fitness components. Since various physical fitness aspects do not change the same as cardiorespiratory fitness during childhood, it is necessary to establish possible associations between cardiorespiratory fitness and other physical fitness components in children. Therefore, the main purpose of the study was to test the associations between cardiorespiratory fitness with motor performance and body size in 7-14-year-old children.MethodsIn this cross-sectional study, we recruited 1612 children (52.5% girls). Health-related physical fitness components included: 1) body-mass index (kg/m2) calculated from height and weight (measure of body size), 2) sit-and-reach test (measure of flexibility), 3) standing long jump (measure of explosive strength), 4) sit-ups in 30 sec (measure of repetitive strength), 5) 10x5 shuttle run test (measure of agility) and 6) 20-m shuttle run test (measure of aerobic capacity). The associations were performed using generalized estimating equations with β coefficients.ResultsAfter adjusting for age, cardiorespiratory fitness was associated with sit-and-reach test (β=0.13, p<0.001), standing long jump (β=0.59, p<0.001), sit-ups in 30 sec (β=0.53, p<0.001) and 10x5 shuttle run test (β=-0.56, p<0.001) in boys. In girls, cardiorespiratory fitness was associated with body-mass index (β=-0.12, p<0.001), sit-and-reach test (β=0.21, p<0.001), standing long jump (β=0.25, p<0.001), sit-ups in 30 sec (β=0.36, p<0.001) and 10x5 shuttle run test (β=-0.40, p<0.001). No significant associations between cardiorespiratory fitness and body-mass index in boys were observed.ConclusionsAlthough significant, cardiorespiratory fitness is weakly to moderately associated with other physical fitness components, pointing out that such measure should be tested separately from other aspects of physical fitness in school-aged children.
Effects of Family Intervention on Physical Activity and Sedentary Behavior in Children Aged 2.5-12 Years: A Meta-Analysis
Authors: Huang Ting , Zhao Guanggao , Guo Zhiqiang , Wu Hua , Fu Jinmei , Sun Shunli , Lv Wendi , He Zihao , Hu Qiming , Quan Minghui 
Published: December 2020

Abstract
Background: To use a quantitative approach to examine the effects of family interventions on physical activity (PA) and sedentary behavior (SB) in children aged 2.5-12 years. Methods: PubMed, OVID, Web of Science, and others were searched from their inception to May 2020. Intervention studies that examined the effects of family interventions on PA among children aged 2.5-12 years were included in this meta-analysis. Lastly, subgroup analyses were conducted to examine the potential modifying effects of family intervention’s characteristics and study quality. Results: Eleven articles met the inclusion criteria for this review. Studies investigated a range of PA outcomes, including moderate-to-vigorous PA (MVPA), total PA (TPA), daily steps, and SB levels. Meta-analysis showed that family intervention had a significant effect on PA [standardized mean difference (SMD)=0.10; 95%CI=0.01, 0.19], especially for daily steps [weight means difference (WMD)=1,006; 95%CI=209, 1,803], but not for SB (WMD=-0.38; 95%CI=-7.21, 6.46). Subgroup analyses indicated the improvements in PA occurred when children were 6-12 years old, intervention focused on PA only, intervention duration ≤ 10 weeks, and “low risk of bias” study performed. Conclusions: Family intervention may be a promising way to promote children’s PA levels, especially for daily steps. Trial registration: Meta-analysis protocol was registered on PROSPERO: CRD42020193667.
Relationship Between Multimorbidity, Combination and All-Cause Mortality Among Older Adults: A Retrospective Cohort Analysis
Authors: He Kun , Zhang Wenli , Hu Xueqi , Zhao Hao , Guo Bingxin , Shi Zhan , Zhao Xiaoyan , Yin Chunyu , Shi Songhe 
Published: December 2020

Abstract
Background: Previous studies have evaluated the association of multimorbidity with higher mortality, but epidemiologic data on the association between the combination of multimorbidity and all-cause mortality risk are rare. We aimed to examine the relationship between multimorbidity (number/combination) and all-cause mortality in Chinese older adults. Methods: We conducted a population-based study of 50,100 Chinese participants. Cox regression models were used to estimate the impact of long-term conditions (LTCs) on all-cause mortality. Results: The prevalence of multimorbidity was 31.35% and all-cause mortality was 8.01% (50,100 participants). In adjusted Cox models, the hazard rations (HRs) and 95% confidence intervals (CIs) of all-cause mortality risk for those with 1, 2, and ≥ 3 LTCs compared with those with no LTCs was 1.10 (1.01-1.20), 1.21 (1.10-1.33), and 1.46 (1.27-1.67), respectively (Ptrend <0.001). In the LTCs ≥ 2 category, the combination of chronic diseases that included hypertension, diabetes, CHD, COPD, and stroke had the greatest impact on mortality. In the stratified model by age and sex, absolute all-cause mortality was higher among the ≥ 75 age group with an increasing number of LTCs. However, the relative effect size of the increasing number of LTCs on higher mortality risk was larger among those < 75 years.Conclusions: The risk of all-cause mortality is increased with the number of multimorbidity among Chinese older adults, particularly combinations.
Prevalence, Associated Factors and Awareness of Hypertensive Retinopathy Among an Elderly Population with Hypertension in Nepal: The Bhaktapur Retina Study
Authors: Thapa Raba , Khanal Shankar , Tan Hendra , Thapa Suman , Rens Gerardus Hermanus Maria Bartholomeus van Rens van 
Published: December 2020

Abstract
Background: This study aimed to assess the prevalence, associated factors and awareness of hypertensive retinopathy among an elderly population with hypertension in Nepal Methods: A population-based, cross-sectional study was conducted from 2013 to 2015 in Bhaktapur district, Nepal. The sample size was 2100 subjects age 60 years and above. From this sample, all diagnosed patients with hypertension were analyzed. A detailed history was obtained, and an ocular examination was performed. Blood sugar and blood pressure were measured. Result: Information was complete for 1860 (88.57%) subjects. The age ranged from 60 to 95 years with the mean ± SD age of 69.64±7.31 years. Hypertension was found in 643 subjects (34.61%), of which 224 (12.04%) were newly diagnosed cases. Hypertensive retinopathy was found in 81 cases (12.6%). Grade 1, grade 2, and grade 3 hypertensive retinopathy comprised 53 (65.43%), 19 (23.46%), and 9 (11.11%) cases, respectively. Hypertensive retinopathy was more frequent in the age group 70-79 years (15.23%) compared to other age groups, among males (13.25%), illiterates (13.56%), diabetics (16.49%), and those with body mass index (BMI) ≥25 kg/m2 (14%). However, none of the factors was found to be statistically significant. Among the subjects with hypertension, awareness of hypertension’s effects on the eyes, retina and vision was found in 13.84%, 8.4%, and 11.98% respectively. Conclusion: Prevalence of hypertension, hypertensive retinopathy and associated factors among an elderly population were similar to other countries. Awareness of hypertensive retinopathy was found in only 8.4%. Increased emphasis should be directed toward improving awareness campaigns. Key words: Hypertension, hypertensive retinopathy, elderly, awareness, Nepal
Hybrid Imaging Reveals Improved Absorbed Dose from Selective Internal Radiation Treatment by Using an Anti-Reflux Catheter
Authors: Rangraz Esmaeel Jafargholi , Tang Xikai , Maleux Geert , Dekervel Jeroen , Cutsem Eric Van , Verslype Chris , Baete Kristof , Nuyts Johan , Deroose Christophe M 
Published: December 2020

Abstract
Selective internal radiation therapy (SIRT) is a promising technique for patients with hepatic malignancies. Several image-based investigations, e.g. volumetric and absorbed dose assessment, are mandatory for SIRT planning and treatment verification based on national and international regulations.General treatment workflows are described in guidelines, recommendations, and the package inserts of the manufactures. But, guidance to tackle particular clinical conditions can be ill-defined and different centers practice their own workflow to analyze the treatment process. This case report includes an example of inconsistency between treatment simulation and observed treatment result, revealed by hybrid imaging. There is no universally accepted standard procedure defined in the literature for detecting and evaluating a possible mismatch between [99mTc]Tc-MAA-based simulation and distribution of the therapeutic microspheres. In this setting, more advanced multi-modal image-based analysis may be beneficial.A 78 year old patient with hepatocellular carcinoma underwent liver radioembolization with resin 90Y-microspheres. Tumoral and non-tumoral dose–volume histograms were evaluated for simulated activity distribution using [99mTc]Tc-MAA-SPECT and post-treatment activity measurement using 90Y-PET. During simulation workup, [99mTc]Tc-MAA particles were administered using a regular catheter. On the other hand, for the treatment session an anti-reflux catheter was used. Our result, suggests that the use of an anti-reflux catheter might improve tumor coverage, and as a result decrease non-tumoral liver uptake deposition.
Clinical outcome of the Intrathecal administration of the allogeneic side population Adipose Derived Mesenchymal Stem Cells in Werdnig Hoffman patients: An open-label Phase I clinical trial
Authors: Mohseni Rashin , Hamidieh Amir Ali , Shoae-Hassani Alireza , Ghahvechi-Akbari Masood , Majma Anahita , Mohammadi Mahmoud , Nikougoftar Mahin , Shervin-Badv Reza , Ai Jafar , Montazerlotfelahi Hadi , Ashrafi Mahmoud Reza 
Published: December 2020

Abstract
Background

Werdnig Hoffman (WH), a hereditary neurodegenerative disorder of lower motoneurons associated with progressive muscle weakness is the most common genetic cause of infant mortality. There is no effective treatment for WH exists. The field of translational research is active now, and clinical trials or case studies are ongoing. We present a phase 1 clinical trial in patients with WH who received side population adipose-derived mesenchymal stem cells (SPADMSCs).
Methods

The intervention group administered with three intrathecal administrations of escalating doses of SPADMSCs. The safety analysis was assessed by controlling the vital signs and efficacy analysis performed by the Ballard score and EMG test. These tests were performed previous to treatment and at the end of the follow-up.
Results

The treatment well-tolerated, without any adverse event related to the stem cell administration. Patients showed significant improvement in the amplitude response of motor in the tibial nerve (0.56 mV; p: 0.029). The weight of patients, ventilation days, and number of hospitalizations were not meaningful parameters in the response of patients in the intervention and control groups. One patient in the intervention group is still alive after 36 months. He gained a normal weight and has a normal growth rate. The patient can breathe without ventilator aid.
Conclusion

The present study for stem cell therapy shows safety and efficacy in WH patients, mainly in the recovery of the tibial nerve, respiratory system, and length of life.