bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Burden of Laboratory-confirmed Influenza Infection in Lebanon Between 2008 and 2016: A single tertiary care center experience
Authors: Assaf-Casals Aia , Saleh Zeina , Khafaja Sarah , Fayad Danielle , Ezzeddine Hady , Saleh Mohammad , Chamseddine Sarah , Sayegh Rouba , Sharara Sima , Chmaisse Ahmad , Kanj Souha , Kanafani Zeina , Hanna-Wakim Rima , Araj George , Mahfouz Rami , Saito Reiko , Suzuki Hiroshi , Zaraket Hassan , Dbaibo Ghassan 
Published: April 2020

Abstract
BACKGROUND: Influenza is a major cause of morbidity and mortality worldwide. Following the 2009 pandemic, there was widened interest in studying influenza burden in all regions. However, since data from the World Health Organization (WHO) Middle East and North Africa (MENA) region remain limited, we aimed to contribute to the understanding of influenza burden in Lebanon.METHODS: A retrospective chart review extending over a period of 8 seasons from Jan 1st, 2008 till June 30th, 2016 at a tertiary care center in Beirut was performed. All cases confirmed to have influenza based on rapid antigen detection or/and polymerase chain reaction on a respiratory sample were included for analysis. Data on epidemiology, clinical presentation, complications, antiviral use and mortality were collected for analysis.RESULTS: A total of 1829 cases of laboratory-confirmed influenza were identified. Average annual positivity rate was 14% (positive tests over total requested). Both influenza A and B co-circulated in each season with predominance of influenza A. Influenza virus started circulating in December and peaked in January and February. The age group of 19-50 years accounted for the largest proportion of cases (22.5%) followed by the age group of 5-19 years (18%). Pneumonia was the most common complication reported in 33% of cases. Mortality reached 3.8%. The two extremes of age (<2 years and ≥ 65years) were associated with a more severe course of disease, hospitalization, intensive care unit (ICU) admission, complications, and mortality rate. Of all the identified cases, 26% were hospitalized. Moderate-to-severe disease was more likely in influenza B cases but no difference in mortality was reported between the two types. Antivirals were prescribed in 68.8% and antibiotics in 41% of cases. There seemed to be an increasing trend in the number of diagnosed and hospitalized cases over the years of the study. CONCLUSION: Patients with laboratory-confirmed influenza at our center had a high rate of hospitalization and mortality. A population based prospective surveillance study is needed to better estimate the burden of Influenza in Lebanon that would help formulate a policy on influenza control.
Effect of number of annual rings and tree ages on genomic predictive ability for solid wood properties of Norway spruce
Authors: Author) Linghua Zhou(Former Corresponding , Chen Zhiqiang , Olsson Lars , Grahn Thomas , Karlsson Bo , Wu Harry , Lundqvist Sven-Olof , Author) María Rosario García-Gil(New Corresponding 
Published: April 2020

Abstract
BACKGROUND: Genomic selection (GS) or genomic prediction is considered as a promising approach to accelerate tree breeding and increase genetic gain by shortening breeding cycle, but the efforts to develop routines for operational breeding are so far limited. We investigated the predictive ability (PA) of GS based on 484 progeny trees from 62 half-sib families in Norway spruce (Picea abies (L.) Karst.) for wood density, modulus of elasticity (MOE) and microfibril angle (MFA) measured with SilviScan, as well as for measurements on standing trees by Pilodyn and Hitman instruments. RESULTS: GS predictive abilities were comparable with those based on pedigree-based prediction. Marker-based PAs were generally 25-30% higher for traits density, MFA and MOE measured with SilviScan than for their respective standing tree-based method which measured with Pilodyn and Hitman. Prediction accuracy (PC) of the standing tree-based methods were similar or even higher than increment core-based method. 78-95% of the maximal PAs of density, MFA and MOE obtained from coring to the pith at high age were reached by using data possible to obtain by drilling 3-5 rings towards the pith at tree age 10-12. CONCLUSIONS: This study indicates standing tree-based measurements is a cost-effective alternative method for GS. PA of GS methods were comparable with those pedigree-based prediction. The highest PAs were reached with at least 80-90% of the dataset used as training set. Density could be conducted at an earlier age than for MFA and MOE. Operational breeding can also be optimized by training the model at an earlier age or using 3 to 5 outermost rings at tree age 10 to 12 years, thereby shortening the cycle and reducing the impact on the tree.
Impact of guided self-study on learning success in undergraduate physiotherapy students in Switzerland – a feasibility study of a higher education intervention
Authors: Rogan Slavko , Taeymans Jan , Zuber Stefan , Zinzen Evert 
Published: April 2020

Abstract
BackgroundGuided self-study (G-SS) can be used as a self-directed learning method (andragogy) or self-determined learning (heutagogy) that fosters changes in knowledge and skills in a higher physiotherapy education setting. Until now, there has been no empirical evidence for the use of G-SS in higher physiotherapy education. This higher education feasibility study aimed to investigate the feasibility to establish a G-SS program in a fulltime undergraduate physiotherapy degree course. In addition, the effectiveness of the G-SS was assessed on changes in knowledge and skills.Method51 first-semester physiotherapy students were randomly divided into a G-SS group or control group (CG). The G-SS group received six cases. Each case was processed in an eight-day cycle. One week in advance, the clinical case and learning goals were provided to the students electronically (day 1). The students prepared the cases in groups and were guided by the tutor during this preparation time (day 2 to 7). The results of the group work were presented and reflected on during a moderated plenum session at day 8. The primary outcome parameters were i) exposure, ii) the responsiveness of students iii) program differentiation, and the total score in the objective structured clinical examination (OSCE) and written exams. Statistical analyses were conducted using an Intention-To-Treat (ITT) approach.ResultsThe responsiveness of students as willing to participate in the G-SS program was 23%, clearly below the set 83%, and in terms of program differentiation.No differences were found between G-SS program and normal curriculum content. G-SS as compared to the CG scored significantly better on OSCE (p < 0.01) and on the written exam (p < 0.04).ConclusionThe results showed that this higher education G-SS program in its current form was not feasible. Slight modification of the study protocol (e.g. better time planning in the academic calendar) is needed to improve the student’s responsiveness. The adjustments to the timetable must allow the physiotherapy students to prepare the clinical cases. G-SS have the potential to promote change in knowledge and skills in undergraduate physiotherapy students when students prepare the case, present the case solutions and reflect upon their actions.Trial registrationRegistry of Efficacy and Effectiveness Studies, Registry ID: #1762.1 Registered on February 26th, 2019
Monocyte-derived chicken macrophages exposed to Eimeria tenella sporozoites display reduced susceptibility to invasion by Toxoplasma gondii tachyzoites
Authors: Zhang Runhui , Zheng Wanpeng , Daugschies Arwid , Bangoura Berit 
Published: April 2020

Abstract
Background: Both Eimeria (E.) tenella and Toxoplasma (T.) gondii are common apicomplexan parasites in chickens. Host cell invasion by both protozoans includes gliding motility, host cell attachment and active penetration. Chicken macrophages as phagocytic cells participate in the innate host immune response against these two parasites. Methods: In this study, primary chicken monocyte-derived macrophages (MMs) were infected with both pathogens to investigate mutual and host-parasite interactions. MMs cultures were assigned to groups that were infected with E. tenella, T. gondii, or both. In co-infected cultures, MMs were first exposed to E. tenella sporozoites for 2 hours. Afterwards, T. gondii tachyzoite infection was performed. Live-cell imaging was carried out to observe cell invasion and survival of T. gondii by single parasite tracking over a period of 20 hours post infection (hpi). Quantitative analysis for parasite replication was performed at 2, 6, 12 and 24 hpi by real-time PCR (qPCR).Results: We found that during early co-infection T. gondii tachyzoites adhered for more than 4 hours to macrophages. Although they displayed high motility, ability to penetrate the cell membrane of the potential host cell was reduced. qPCR results confirmed that significantly less T. gondii entered E. tenella-activated MMs at 2 hpi, and a reduced proportion of intracellular T. gondii survived and replicated in these cells at 24 hpi. Conclusions: We conclude that E. tenella modulates host cell responses to another apicomplexan agent, T. gondii, reducing active invasion and multiplication in chicken primary macrophages.
Prostaglandin E1 Attenuates Post-Cardiac Arrest Myocardial Dysfunction via Inhibiting Mitochondria-Mediated Cardiomyocyte Apoptosis
Authors: Su Chenglei , Fan Xinhui , Xu Feng , Wang Jiali , Chen Yuguo 
Published: April 2020

Abstract
Background: Post-cardiac arrest myocardial dysfunction (PAMD) is a leading cause of death in resuscitated patients after cardiac arrest (CA). Prostaglandin E1 (PGE1) is a clinical drug used to mitigate ischemia injury. However, its effect on PAMD remains unknown. Methods: We investigated the protective effects of PGE1 on PAMD in a rat model of cardiac arrest and a hypoxia-reoxygenation (H/R) H9c2 cell model. Forty-two male Wistar rats were randomly assigned to CA, CA+PGE1, and sham groups. Asphyxia for 8 min followed by cardiopulmonary resuscitation was performed in the CA and CA+PGE1 groups. PGE1 (1 μg/kg) was intravenously administered at the onset of return of spontaneous circulation (ROSC). Ejection fraction (EF) and cardiac output (CO) were measured at baseline, 1, 2, 3, and 4 h after ROSC; survival was monitored for 72 h. Cardiomyocyte apoptosis, mitochondrial permeability transition pore (mPTP) opening, and protein levels of glycogen synthase kinase 3β (GSK3β), cytochrome c, and cleaved caspase-3 were measured 4 h after ROSC. H9c2 cells were treated with PGE1(0.5 μM) at the start of reoxygenation. Apoptosis, mPTP opening, and protein levels of GSK3β, cytochrome c, and cleaved caspase-3 of H9c2 cells were detected. Results: Compared to the CA group, PGE1 treatment significantly increased the EF and CO within 4 h after ROSC and improved the survival rate. It activated GSK3β, prevented mPTP opening, suppressed cytochrome c and cleaved caspase-3 expression, and reduced cardiomyocyte apoptosis in the rat model. In vitro, Changes in GSK3β, mPTP opening, cytochrome c and cleaved caspase-3 expression, and apoptosis in H9c2 cells were consistent with those in the rat model. Conclusions: Our results indicate that PGE1 attenuates PAMD via inhibiting mitochondria-mediated cardiomyocyte apoptosis.
Influence of self-management on patient-reported outcomes for individuals with chronic heart failure: a multilevel model approach from a longitudinal study
Authors: Tian Jing , Zhao Jinghua , Zhang Qing , Ren Jia , Han Linai , Li Jing , Zhang Yanbo , Han Qinghua 
Published: April 2020

Abstract
Purpose: Self-management is highly heterogenous in patient-reported outcomes in individuals with chronic heart failure and lacks a clinical definition. The aim of this study was to identify clinically meaningful strategies that improve patient-reported outcomes in those with chronic heart failure.Methods: A multicenter, prospective cohort study of 555 patients with heart failure were enrolled from May 2017 to May 2019. Self-management advice was provided in written form at discharge. Information regarding chronic heart failure in patient-reported outcomes and self-management was collected during follow-up. Multilevel models were applied to dynamically evaluate the effects of self-management strategies for patient-reported outcome of chronic heart failure (CHF-PRO) scores, as well as its physical and psychological domains. Minimal clinically important difference was introduced to further evaluate clinical significance.Results: Scores for CHF-PRO improved significantly after discharge. A regular schedule, avoidance of over-eating, and a low-sodium diet increased scores on patient-reported outcomes, including overall scores and physical and psychological scores. In addition, exercise improved patient-reported outcomes and its physical domain. The use of angiotensin-converting enzyme inhibitors also increased physical scores. Among these variables, a regular daily schedule and avoidance of over-eating almost every day reached clinical significance for CHF-PRO scores, as well as its physical and psychological domains.Conclusions: Self-management, especially the avoidance of over-eating and maintenance of a regular schedule, should be implemented to improve patient-reported outcomes in those with chronic heart failure.Trial registration: 2018LL128, January 2, 2018.
Penataan Kawasan Wisata Curug Banyu Nibo Desa Sendangsari Kecamatan Pajangan Kabupaten Bantul Daerah Istimewa Yogyakarta
Authors: Setiadi Amos , Rudwiarti Lucia Asdra 
Published: April 2020

“Pengabdian pada Masyarakat” (Abdimas) of Curug Banyu Nibo was done to assist partner by designing tourism supporting facilities. The intended outcomes of this Abdimas are the increase of tourist visits and its effect on the welfare of the surrounding local communities. The Abdimas was conducted in three steps, i.e. Preparation and Data Collection; Location Survey and Interviewing Partners; Drafting Concepts and Designs. The conclusion of the program is a design of tourism supporting facilities in Curug Banyu Nibo such as gate, joglo, parks, pathways, gazebos, and culinary stalls.
Pengaruh Pendidikan dan Pekerjaan Terhadap Kemiskinan Rumah Tangga dengan Lingkungan Sebagai Variabel Moderating di Kecamatan Bolano Kabupaten Parigi Moutong
Authors: Indrawati Indrawati , Ermawati Ermawati , Istiqamah Rabaniyah 
Published: April 2020

Tujuan penelitian ini untuk mengetahui apakah variabel pendidikan, pekerjaan berpengaruh terhadap kemiskinan rumah tangga dan apakah variabel kesehatan lingkungan merupakan variabel modereting. Penelitian ini menggunakan penelitian Kuantitatif dengan Teknik pengumpulan data melalui observasi, wawancara, dan kuesioner. Populasi pada penelitian ini adalah seluruh rumah tangga miskin. Sampel dari penelitian ini berjumlah 95 responden. Teknik pengambilan sampel purposive sampling.Teknik analisis data yang digunakan adalah analisis regresi linear berganda dan analisis residual. Berdasarkan pengolahan data yang telah dilakukan menggunakan SPSS Statistics 21.0 menunjukkan bahwa secara parsial variabel pendidikan berpengaruh positif (+) dan signifikan terhadap kemiskinan rumah tangga dengan besaran pengaruhnya 32,1%, sedangkan variabel pekerjaan berpengaruh negatif (-) dan tidak signifikan dengan besaran pengarunhnya 12,8%, dan secara simultan variabel pekerjaan dan pendidikan berpengaruh terhadap kemiskinan rumah tangga dengan besar pengaruhnya 7,7%. Sedangkan variabel lingkungan bukan sebagai variabel moderating karena pada uji residual tahap pertama (X1) dan tahap kedua (X2) menunjukkan hasil yang positif pada nilai coefficients beta dan nilai sig > 0,05.
Pengaruh Etika Bisnis Islam Terhadap Keputusan Pembelian Busana Muslimah Mahasiswi Jurusan Ekonomi Syariah IAIN Palu
Authors: Sasnita Afriyani , Musyahidah Siti , Nursyamsu Nursyamsu 
Published: April 2020

Penelitian ini bertujuan untuk mengetahui pengaruh etika bisnis Islam terhadap keputusan pembelian busana Muslimahpada mahasiswi Jurusan Ekonomi Syariah Institut Agama Islam Negeri (IAIN) Palu. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif. Data yang digunakan adalah data primer dengan pengumpulan data melalui kuesioner dan dokumentasi. Dengan menggunakan tehnik proportionalstratified random sampling, sampel yang digunakan 83 responden, yang dijadikan responden dalam penelitian ini adalah mahasiswi yang pernah berbelanja busana Muslimah. Uji yang digunakan untuk menguji instrumen penelitian adalah uji validitas, dan uji reliabilitas. Selanjutnya analisis data dilakukan secara kuantitatif dengan metode Analisis Regresi Linier Sederhana. Hasil penelitian ini menunjukan bahwa etika bisnis Islam berpengaruh positif dan signifikan terhadap keputusan pembelian busana Muslimah pada mahasiswi jurusan ekonomi syariah Institut Agama Islam Negeri (IAIN) Palu serta telah memenuhi syarat uji regresi sederhana yakni hasil olahan data menunjukan bahwa perolehan model persamaan regresi yaitu Y= 12,380 + 0,436X. Koefisien regresi variabel etika bisnis Islam (X) berpengaruh terhadap keputusan pembelian busana Muslimah pada mahasiswi jurusan ekonomi syariah IAIN Palu sebesar 0,436, uji koefisien kolerasi menunjukan bahwa R sebesar 0,349 ini menunjukan bahwa variabel etika bisnis Islam (X) memiliki pengaruh kontribusi sebesar 34,9% terhadap keputusan pembelian busana Muslimah (Y). Sedangkan sisanya (100% - 34,9% = 65,1%) dijelaskan oleh sebab-sebab yang lain diluar variabel yang diteliti.
Constitutional and legal bases for the formation of the Senate of the Australian Commonwealth
Authors: Voytovich E. A. 
Published: April 2020

Introduction. The article is devoted to the organizational and legal issues of formation of the Senate of the Commonwealth of Australia. The author analyses the foundations of the constitutional regulation of the formation of the Senate. Now there are no works exploring in detail the manner the Senate of the Australian Commonwealth is formed.Materials and Methods. To create the article, the author used the works of Australian scholars in the field of constitutional law, as well as a number of legal acts regulating the issues addressed in the article. The methodology of the study was based on general scientific and private scientific methods of cognition (the dialectical method, methods of analysis and synthesis, deduction and induction, comparative legal and historical legal methods).Research Results. The author has considered specific characteristics of the Senate and in particular the constitutional norm establishing the system where senators are elected directly by the people of each entity of the Australian Commonwealth. The author also analyses the formation of the electoral system applied to formation of the Senate of the Australian Commonwealth.Discussion and conclusions. In this article, the author draws attention to the stability and invariability of the foundations of Senate legal regulation, established by the Constitution of the Australian Union, approved by the British Parliament and signed by the British monarch. The author pays attention to the peculiarities of the formation of the Australian legislature.
Intradural lumbar disc herniations at the L1–L2 level: A case study and literature review
Authors: Ponzo Giancarlo , Furnari Massimo , Umana Giuseppe Emmanuele , Giuffrida Massimiliano , Nicoletti Giovanni Federico , Scalia Gianluca 
Published: April 2020

Background:
Intradural disc herniations (IDHs) are rare occurrences (0.26–0.30%), and most frequently involve the lumbar spine at the L4–L5 level. Here, we present a patient with an L1–L2 IDH and reviewed the current literature.

Case Description:
A 65-year-old female presented with the acute onset of bilateral paraparesis accompanied by urinary dysfunction. The lumbar MRI showed a mass at the L1–L2 level with caudal migration, accompanied by a positive “hawk-beak” sign. At surgery, consisting of a L1–L2 laminectomy, a large IDH was encountered responsible for marked cauda equina/root compression. Postoperatively, the patient immediately fully recovered. The literature we identified cited just seven similar studies of L1–L2 IDH.

Conclusion:
In a 65-year-old female, an IDH was anticipated at the L1–L2 level due to the combined MR findings of a large L1–L2 mass with caudal migration and the positive “hawk-beak” sign.
STUDENT'S LANGUAGE LEARNING STRATGIES IN LISTENING
Authors: Ariani Retno , Arifin Zainal , Riyanti Dwi 
Published: April 2020

This research was aimed to describe language learning strategies in listening used by a third semester student of English Education Study Program who gets high achievement in listening English comprehension. This research was a qualitative research. The subject of this research was a successful language learner from a third semester student. This research was a case study which used observation and interview as the instruments of data collecting. The observation was done using direct and indirect observation and for the interview was done using semi structured interview that supported by a narrative analysis. The result of data analysis indicated that the student who categorized as a successful language learner in listening comprehension used the four framework of listening strategies by Goh and Kaur (2017) as the representative of language learning strategies in listening which proposed by O’Malley and Chamot (1990). Based on the result, the student who gets high achievement in listening English comprehension employed four strategies namely directed/selective attention strategies, planning and evaluation strategies, problem solving strategies and mental translation strategies. The findings revealed that the student who categorized as a successful language learner in this research was not achieving the goal of learning instantly
A comprehensive review on application of stem cells for kidney diseases
Authors: Chetan Kumar V H  , Famna Roohi N K  , Gowda D V  
Published: April 2020

The recognition of kidney failure as a complex disease requires multifactorial therapy in order to correct the conventional nonfactorial deficiency. Firstly, self-renewal means the ability of most organisms to reproduce without separation or aging; secondly, more than one form of a mature somatic cell is identified by each of the three regardless of kidney disorders, it can lead to loss of the environment, often bacterial infections. The reconstruction of the kidney has produced a spectacular response in this framework. The restoration of weakened and new kidneys is an alternative to renal replacement therapy. Both teratomas and embryoid bodies consist of three different layers of embryonic germs. Induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) are present. These either provide useful therapeutical resources or can explore pathophysiology, including kidney diseases or infection. The benefit of ESCs is that they are relatively quick to receive and no longer subject to licensing/realty fees. Nevertheless, there are still some major concerns, such as ethical issues, the high risks to degeneration of neoplasm and immunocompatibility. The great benefit of iPSCs is that they have the same genetic history they drive making them an excellent method for studying the impact of genetic variants on disease path the key risk associated with the use of iPSCs are oogenesis, Tumorigenicity, and immunogenicity, the presence of an epigenetic memory, technical and economic issue associatedwith their long turnaround time and the presence of loyalties are the key risks associated with the use of iPSCs. Human pluripotent SCs have two major areas of use in kidney regeneration: they can be used by way organoid, scaffold,organ-on-a-chip, or blastocyst experiment to develop a "new kidney" or part of it. Renal progenitor cells are an alternative to either test or modulate regeneration of the kidney, offering significant benefits in the field. For encouraging us to hypothesize their medical use, a deeper understanding of the biology of pluripotent SCs is necessary.