bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validity of physical examination in the thorax and abdomen of intoxicated trauma patients following a fall: An exploratory retrospective review
Authors: Chetram Vishaka K , Kopatsis Anthony P , Kopatsis Anthony 
Published: February 2020

Background Whole-Body Computerized Topography (WBCT) scans can be used to identify injuries related to trauma in intoxicated patients who often cannot provide a reliable history. While WBCT scans are associated with a decreased mortality and hospital stay in patients with a high energy mechanism of injury, their utility in intoxicated patients following a fall remain unclear. The objective of this study was to evaluate the validity of physical examination in the thorax and abdomen to identify injuries in the intoxicated patient following a fall when compared to WBCT scan findings. Methods A retrospective chart review was performed over a two-year period of intoxicated trauma patients who were found down secondary to a witnessed fall <20 ft, GCS > 8 and not requiring intubation. Documented physical examination findings were compared to WBCT results. Sensitivity, specificity, positive predictive value, and negative predictive value were calculated. A t-test was used to identify differences between clinical variables of false-negative and true-negative physical examinations. Results A total of 523 intoxicated patients presented to the ED with 43 meeting the inclusion criteria. All patients had an injury that required admission to the hospital. Of 19 patients with a positive chest CT, 13 had a negative physical exam, for sensitivity of 32% and specificity of 96%. Of eight patients with a positive abdominal CT, six had a negative physical exam, sensitivity and specificity were 16% and 98% respectively. No clinical variables were found to be different between falsely negative and true negative physical exam results. Conclusion In the acutely intoxicated trauma patient, physical examination findings of the thorax and abdomen were associated with a low validity, having missed an unacceptably high number of injuries, when compared to WBCT scans.
Halal landscapes of Dagestani entrepreneurs in Makhachkala
Authors: Kaliszewska Iwona 
Published: February 2020

It has recently become increasingly popular for small entrepreneurs in Dagestan to introduce elements of Islamic economy into their everyday economic practices. In my paper, I take a closer look at everyday life and the ways of conducting business among small entrepreneurs in Makhachkala, the capital of the Republic of Dagestan in the Russian Federation.  In order to scrutinize the relationship between everyday religious observance, space and economic practices within a broader socio-political context, I introduce the term ‘halal landscape’. ‘Halal landscapes’ emerge through the gradual infusion of Islam into the sphere of economic activities, where they form ‘Islam-inspired’ social spaces, in which economic and moral dimensions are interwoven with formal and informal norms and regulations, and where social life – the area of interaction between human and non-human actors – has its unique materiality and temporality.  In my paper, I look into the halal landscapes of Dagestani entrepreneurs in Makhachkala and demonstrate the analytical potential of the term to study the social and cultural nature of Islam-inspired economic practices. Important elements of these halal landscapes include the avoidance of deception and usury, promotion of honesty and observance in the workplace, payment of zakat, as well as thorough knowledge about these issues.  My analysis is based on the results of multi-temporal fieldwork conducted in Makhachkala in 2017–2019 as well as on earlier field observations gathered during regular visits in 2004–2016.
Telmisartan improves myocardial remodeling by inhibiting leptin autocrine activity and activating PPARγ
Authors: Chen Hui , Li Min , Liu Lei , Zhu Danjun , Tian Gang 
Published: February 2020

The mechanism responsible for myocardial remodeling in hypertensive left ventricular hypertrophy (LVH) is complex. This study was designed to investigate the role of telmisartan in improving myocardial remodeling in hypertensive LVH and to explore the molecular mechanisms underlying the effects of telmisartan on hypertensive LVH. Hypertensive LVH was established in eight-week-old male Sprague–Dawley (SD) rats by abdominal aortic constriction. Telmisartan was intragastrically administered six weeks after surgery. Telmisartan improved cardiac dysfunction and myocardial fibrosis and reduced myocardial renin-angiotensin-aldosterone system (RAAS) activity and leptin levels in hypertensive LVH rats. To assess the mechanism underlying hypertensive LVH, cardiac fibroblasts were treated in vitro with angiotensin II (Ang II) or leptin, plus various inhibitors. Ang II stimulated leptin synthesis and secretion in cardiac fibroblasts by promoting AP-1 nuclear translocation via the AT1R-ROS-ERK1/2 pathway. Leptin induced collagen metabolism disorder in cardiac fibroblasts via the JAK2/STAT3 pathway. Telmisartan improved collagen metabolism disorder by inhibiting leptin induced by local Ang II in an autocrine manner. Telmisartan also improved Ang II-induced collagen metabolism disorder by inhibiting STAT3 phosphorylation, a leptin downstream signal, by activating PPAR-γ. Telmisartan therefore improved myocardial remodeling in hypertensive LVH rats by acting as an AT1R antagonist, inhibiting leptin autocrine activity induced by local Ang II and by acting as a PPAR-γ agonist, inhibiting downstream leptin activation of STAT3 phosphorylation. These findings indicate the crosstalk between local myocardial RAAS and leptin and suggest a molecular mechanism by which telmisartan improves myocardial remodeling in hypertensive LVH.Impact statementThis study shows the crosstalk between local myocardial RAAS and leptin in hypertensive LVH rats; that Ang II induces myocardial remodeling by stimulating leptin autocrine activity by promoting AP-1 nuclear translocation via the AT1R-ROS-ERK1/2 pathway; and that telmisartan improves myocardial remodeling by inhibiting local Ang II-induced leptin autocrine activity and by inhibiting the leptin downstream signal STAT3 phosphorylation by activating PPAR-γ. These findings reveal novel molecular mechanisms by which telmisartan improves myocardial remodeling and could help to identify therapeutic targets for hypertensive LVH.
Vascular complications during transcatheter aortic valve implantation: The role of the vascular surgeon
Authors: Filis Konstantinos , Galyfos George , Sigala Fragiska , Karantzikos Georgios , Vavouranakis Manolis , Toutouzas Konstantinos , Albanopoulos Konstantinos , Zografos Georgios 
Published: February 2020

Introduction This study compares the incidence of vascular complications and other major outcomes between patients undergoing transcatheter aortic valve implantation, with and without a standardized preoperative vascular surgeon consultation. Methods This retrospective study evaluated all patients scheduled for transcatheter aortic valve implantation during a five-year period at a Hellenic University Hospital. Two main periods were evaluated: Group A (early period (2014–2015), without a standardized preoperative vascular surgeon consultation) and Group B (late period (2016–2018), with a standardized preoperative vascular surgeon consultation). All vascular complications as well as other major outcomes (early death, stroke, myocardial infarction, and treatment) were recorded. Univariate and multivariate analyses were also conducted. Results Overall, 382 transcatheter aortic valve implantation procedures were conducted (Group A: n = 115; duration = 19 months; Group B: n = 267; duration = 41 months). Overall, 58 vascular complications were recorded (21 patients in Group A and 37 patients in Group B (18.3% versus 13.9%; P = 0.279)). However, vascular complications that necessitated a vascular surgeon’s interference were more frequent during the first period (13% versus 4.9%; P = 0.009). Among patients with a vascular complication, early mortality was higher during the first period (14.3% versus 0%; P = 0.034) although stroke and myocardial infarction rates were similar. Age >80 years (OR = 1.856 [1.134–3.452]; P = 0.03) and preoperative vascular surgeon consultation (OR = 0.345 [0.132–0.756]; P = 0.015) were the only independent predictors for vascular complications. Conclusions A standardized preoperative evaluation by a vascular surgeon may decrease the risk for vascular complications that necessitate a repair as well as early mortality among patients undergoing transcatheter aortic valve implantation procedures.
Prognostic significance of early urinary catheterization after acute stroke: Secondary analyses of the international HeadPoST trial
Authors: Ouyang Menglu , Billot Laurent , Song Lili , Wang Xia , Roffe Christine , Arima Hisatomi , Lavados Pablo M , Hackett Maree L , Olavarría Verónica V , Muñoz-Venturelli Paula , Middleton Sandy , Pontes-Neto Octavio M , Lee Tsong-Hai , Watkins Caroline L , Robinson Thompson G , Anderson Craig S 
Published: February 2020

Background An indwelling urinary catheter (IUC) is often inserted to manage bladder dysfunction, but its impact on prognosis is uncertain. We aimed to determine the association of IUC use on clinical outcomes after acute stroke in the international, multi-center, cluster crossover, Head Positioning in Acute Stroke Trial (HeadPoST). Methods Data were analyzed on HeadPoST participants (n = 11,093) randomly allocated to the lying-flat or sitting-up head position. Binomial, logistic regression, hierarchical mixed models were used to determine associations of early insertion of IUC within seven days post-randomization and outcomes of death or disability (defined as “poor outcome,” scores 3–6 on the modified Rankin scale) and any urinary tract infection at 90 days with adjustment of baseline and post-randomization management covariates. Results Overall, 1167 (12%) patients had an IUC, but the frequency and duration of use varied widely across patients in different regions. IUC use was more frequent in older patients, and those with vascular comorbidity, greater initial neurological impairment (on the National Institutes of Health Stroke Scale), and intracerebral hemorrhage as the underlying stroke type. IUC use was independently associated with poor outcome (adjusted odds ratio (aOR): 1.40, 95% confidence interval (CI): 1.13–1.74), but not with urinary tract infection after adjustment for antibiotic treatment and stroke severity at hospital separation (aOR: 1.13, 95% CI: 0.59–2.18). The number exposed to IUC for poor outcome was 13. Conclusions IUC use is associated with a poor outcome after acute stroke. Further studies are required to inform appropriate use of IUC.
Ergonomics and musculoskeletal symptoms in surgeons performing endoscopic procedures for benign prostatic hyperplasia
Authors: Omar Mohamed , Sultan Mohamed F. , El Sherif Eid , Abdallah Mohamed M. , Monga Manoj 
Published: February 2020

Background and purpose: Benign prostatic hyperplasia (BPH) is the most common urologic disorder affecting older men, necessitating medical or surgical intervention. Limited data exists regarding the effect these surgeries have on the endourologist’s musculoskeletal system following the surgery because of the required difficult posture, prolonged procedures, repetitive movements, and the settings of an adjustable visual display terminal workstation. The aim of our study was to survey the prevalence and possible causes of musculoskeletal disorders among endourologists performing transurethral resection of the prostate (TURP) or laser prostatectomy using either holmium laser enucleation or thulium laser enucleation. Materials and methods: An email inviting all members of the Endourological Society to participate in the survey was sent. The questionnaire included different demographic and practice characteristics, with concern regarding performing either TURP or laser prostatectomy and the incidence and type of musculoskeletal incidents following these surgeries. All responses were collected by a commercially available internet based survey host ( www.surveymonkey.com ) over a period of 6 weeks. Results: Of the 121 complete responses, 84 (69%) of endourologists complained of a musculoskeletal disorder following TURP or laser prostatectomy. The most frequent complaint was for neck (64%), followed by back (57%), shoulder (48%), hand (40%), and elbow (18%). The average prostate volume turned out to be the most compelling predictor for musculoskeletal disorder occurrence with an average prostate volume of 76 g operated on by the complaining group compared with 59 g in the noncomplaining group. Those with more severe symptoms were linked to a mean prostate size of 80 g (60–146) and constantly complained of shoulder, neck, or back trouble compared with the less-severely complaining group. Conclusions: A high prevalence of musculoskeletal complaints among urologists performing endourologic prostatectomy was confirmed and was found to be proportionally related to the size of the prostate. The integration of an ergonomic specialist inside the operation room to watch and correct the surgeon’s position during endourologic procedures may reduce the endourologist’s exposure to these occupational hazards.
Why residents quit: Prevalence of and reasons for attrition among anaesthesia residents in a single sponsoring institution
Authors: Moo Daphne , Siow Wei Shyan , Ong Ee Teng 
Published: February 2020

Background: The SingHealth Anaesthesiology Residency Programme (SHARP) is a 5-year postgraduate training programme in Singapore. Since its inauguration in 2011, SHARP has taken in the largest number of anaesthesia residents in Singapore. However, we noticed significant attrition over the years. As attrition is a costly and disruptive affair, both to the individual and the programme, we seek to investigate the prevalence of and reasons for separation, in order to determine ways to minimize attrition. Methods: An online anonymous survey was conducted among all residents who have separated from SHARP. The questionnaire comprised questions regarding demographic data, reasons behind separation, obstacles faced during residency, and potential ways to reduce attrition. Results: From 2011 to 2018, 22 out of 127 residents have separated from the programme, giving an overall attrition prevalence of 17%. Nineteen (86%) of the separated residents responded to our questionnaire. The most common reason for separation was due to difficulties in juggling childcare and training commitments. Of the residents who have separated, more than half of them would consider rejoining the programme if a less than full time (LTFT) option was available. Conclusion: One out of every six residents in the SHARP quits residency training. The reasons behind separation are often varied due to each resident’s unique social circumstances. An individualized training programme with a LTFT option that allows for flexibility may boost retention in the programme.
Unpacking mHealth interventions: A systematic review of behavior change techniques used in randomized controlled trials assessing mHealth effectiveness
Authors: Dugas Michelle , Gao Guodong (Gordon) , Agarwal Ritu 
Published: February 2020

Objective Mobile health interventions have surged in popularity but their implementation varies widely and evidence of effectiveness is mixed. We sought to advance understanding of the diversity of behavior change techniques in mHealth interventions, especially those that leverage advanced mobile technologies. Methods We conducted a systematic review of articles published between 2007 and 2017 in high-impact journals in medicine, medical informatics, and health psychology to identify randomized controlled trials in which the effectiveness of an mobile health intervention was tested. Search terms included a mix of general (e.g. mobile health), hardware (e.g. Android, iPhone), and format (e.g. SMS, application) terms. Results In a systematic review of 21 studies, we found the techniques of personalization, feedback and monitoring, and associations were most commonly used in mobile health interventions, but there remains considerable opportunity to leverage more sophisticated aspects of ubiquitous computing. We found that prompts and cues were the most common behavior change techniques used in effective trials, but there was notable overlap in behavior change techniques used in ineffective trials. Conclusions Our results identify techniques that are commonly used in mobile health interventions and highlight pathways to advance the science of mobile health.
Marketing research in China during the 40-year reform and opening
Authors: Hu Yu , Wang Yonggui 
Published: February 2020

AbstractChina’s reform and opening up policy initiated by the then leader Deng Xiaoping have undergone a 40-year process since 1978. This period was marked by one of the greatest economic reforms in modern history. In this study, we extract literature focused on the Chinese marketization context and marketing practices published in top-tier international marketing journals and Chinese management journals between 1978 and 2018. This study identifies the research questions and research domains investigated in our selected literature. The authors hope to reveal the general landscape and evolution made in the context of this unique period in Chinese history. This thematically focused literature review provides marketing scholars with a snapshot of the academic marketing research in China and gives rise to novel research directions related to the deepening of the economic reform.
Impact of clinical stage on the outcome of laparoscopic radical cystectomy: a prospective cohort study
Authors: Ashmawy Ahmed Abdallah , Assem Ahmed , Abd El Hamid Mahmoud , Salem Ahmed , Kassem Ayman , Abdel Hakim Mahmoud Amr , ElSheemy Mohammed Said , Saad Ismail Rady , Abo El-Ela Ashraf , Elgammal Mohamed 
Published: February 2020

Abstract
Background
Some authors recommend not to perform laparoscopic radical cystectomy (LRC) for large bulky bladder cancer (BC) as the laparoscopic manipulation will be difficult. As there were no prospective studies focusing on the effect of the tumor stage of BC on the outcome of LRC, the aim of this prospective cohort study was to evaluate the effect of tumor stage on the outcome of LRC.

Results
LRC was completed for 47 patients. All patients were followed for at least 1 year, and there was no recurrence. COPD, DM, hypertension and renal impairment were detected, respectively, in 57.4%, 36.2%, 44.7% and 10.6% of patients. Transitional cell carcinoma and squamous cell carcinoma were found, respectively, in 91.5% and 8.5% of patients. Complications were reported in 29.78% including 29.78% Clavien grade 1, 17.02% grade 2 and 6.38% grade 3. There was no significant difference between cT2 and cT3 in perioperative criteria including demographic features, operative time, estimated blood loss, blood transfusion, pain score, hospital stay and complications. Upon final pathological assessment, 44.68% of patients were upgraded to higher pathological stages. Additional comparison was performed according to pathological stage and revealed no significant difference in the outcome of LRC between pT2 and higher stages except the pain score at first postoperative day which was higher in patients with pT3 stage.

Conclusion
LRC is a feasible and safe technique for both T2 and T3 clinical and pathological stages.
Effects of ordered mutations on dynamics in signaling networks
Authors: Mazaya Maulida , Trinh Hung-Cuong , Kwon Yung-Keun 
Published: February 2020

Abstract
Background
Many previous clinical studies have found that accumulated sequential mutations are statistically related to tumorigenesis. However, they are limited in fully elucidating the significance of the ordered-mutation because they did not focus on the network dynamics. Therefore, there is a pressing need to investigate the dynamics characteristics induced by ordered-mutations.

Methods
To quantify the ordered-mutation-inducing dynamics, we defined the mutation-sensitivity and the order-specificity that represent if the network is sensitive against a double knockout mutation and if mutation-sensitivity is specific to the mutation order, respectively, using a Boolean network model.

Results
Through intensive investigations, we found that a signaling network is more sensitive when a double-mutation occurs in the direction order inducing a longer path and a smaller number of paths than in the reverse order. In addition, feedback loops involving a gene pair decreased both the mutation-sensitivity and the order-specificity. Next, we investigated relationships of functionally important genes with ordered-mutation-inducing dynamics. The network is more sensitive to mutations subject to drug-targets, whereas it is less specific to the mutation order. Both the sensitivity and specificity are increased when different-drug-targeted genes are mutated. Further, we found that tumor suppressors can efficiently suppress the amplification of oncogenes when the former are mutated earlier than the latter.

Conclusion
Taken together, our results help to understand the importance of the order of mutations with respect to the dynamical effects in complex biological systems.
An inducible Cre mouse line to sparsely target nervous system cells, including Remak Schwann cells
Authors: Sapkota Darshan , Dougherty Joseph D. 
Published: February 2020

AbstractNerves of the peripheral nervous system contain two classes of Schwann cells: myelinating Schwann cells that ensheath large caliber axons and generate the myelin sheath, and Remak Schwann cells that surround smaller axons and do not myelinate. While tools exist for genetic targeting of Schwann cell precursors and myelinating Schwann cells, such reagents have been challenging to generate specifically for the Remak population, in part because many of the genes that mark this population in maturity are also robustly expressed in Schwann cell precursors. To circumvent this challenge, we utilized BAC transgenesis to generate a mouse line expressing a tamoxifen-inducible Cre under the control of a Remak-expressed gene promoter (Egr1). However, as Egr1 is also an activity dependent gene expressed by some neurons, we flanked this Cre by flippase (Flpe) recognition sites, and coinjected a BAC expressing Flpe under control of a pan-neuronal Snap25 promoter to excise the Cre transgene from these neuronal cells. Genotyping and inheritance demonstrate that the two BACs co-integrated into a single locus, facilitating maintenance of the line. Anatomical studies following a cross to a reporter line show sparse tamoxifen-dependent recombination in Remak Schwann cells within the mature sciatic nerve. However, depletion of neuronal Cre activity by Flpe is partial, with some neurons and astrocytes also showing evidence of Cre reporter activity in the central nervous system. Thus, this mouse line will be useful in mosaic loss-of-function studies, lineage tracing studies following injury, live cell imaging studies, or other experiments benefiting from sparse labeling.