bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between hysterosalpingography findings and female infertility in a Nigerian population
Authors: Adedigba Joseph A. , Idowu Bukunmi M. , Hermans Sarah P. , Ibitoye Bolanle O. , Fawole Oluwatunmise A. 
Published: April 2020

PurposeThis study aims to explore the relationships between abnormal hysterosalpingography (HSG) findings and all types of infertility.Material and methodsThis retrospective study was carried out at a private radiodiagnostic centre in Lagos, Nigeria. The radiologist reports of all consecutive patients who had HSG evaluation from 2016 to 2018 were analysed. Biodemographic information and indications for HSG evaluation were also documented. Logistic regression was used to test correlations between the explanatory and outcome variables. P ≤ 0.05 represented a statistically significant result.ResultsA total of 450 patients were involved in this study, with ages ranging from 21 to 51 years and a mean age of 34.6 ± 5.56 years. The age group 31-35 years had the highest frequency of infertility. There were 299 patients referred for infertility. Secondary infertility was seen in 211 patients (46.9%), primary infertility was seen in 79 patients (17.6%), and subfertility was seen in nine patients (2%). There were 49 patients (10.9%) with cornual tubal blockage, while 57 patients (12.7%) had perifimbrial adhesion and/or blockage. There were 56 patients (12.4%) with hydrosalpinx and nine patients (2.0%) with tubal occlusion. Multivariate logistic regression analysis showed women with hydrosalpinx were 2.11 times more likely to be infertile than those without hydrosalpinx (95% CI: 1.02-4.36, p = 0.042).ConclusionsThe presence of hydrosalpinx was a significant risk factor in developing all types of infertility. Understanding the HSG patterns and their correlations with infertility will help physicians across the world when evaluating infertility in patients of similar background to our patient population.
Desensitization to biological agents used in rheumatology
Authors: Makowska Joanna , Lewandowska-Polak Anna 
Published: April 2020

Biological agents such as monoclonal antibodies and fusion proteins are widely used for the treatment of patients with various rheumatic disorders, influencing the quality of life, disability and even mortality in patients. However, biological agents can evoke adverse reactions of different grades of severity. Although drug avoidance remains a gold standard in the care of patients hypersensitive to medication, in certain clinical situations the culprit drug is the drug of choice and cannot be replaced by another equally effective compound. In such cases, desensitization can allow the patient to be treated within current guidelines and with the most effective treatment. <br />
The authors searched Medline and Scopus databases for English-language sources using the following key words: hypersensitivity, desensitization, biologicals, adalimumab, etanercept, adalimumab, certolizumab, golimumab, rituximab, infliximab, ixekizumab, tocilizumab, anakinra and canakinumab. <br />
The aim of our review is to present the current knowledge about desensitization to biological agents and some guidelines according to patient inclusion, contraindications, procedures, and safety requirements. <br />
Drug desensitization is a new issue in rheumatology, and the solution to the problem of allergic reactions to biological drugs, which gives patients with rheumatic diseases the opportunity to extend and prolong their therapy. The present article is one of the first widely discussing this topic in the biological treatment of rheumatic diseases.
Provenance of the cross sign of 806 in the Anglo-Saxon Chronicle: a possible lunar halo over continental Europe?
Authors: Uchikawa Yuta , Cowley Les , Hayakawa Hisashi , Willis David M. , Stephenson F. Richard 
Published: April 2020

Abstract. While graphical records of astronomical/meteorological events before
telescopic observations are of particular interest, they have frequently
undergone multiple instances of copying and may have been modified from the original.
Here, we analyse a graphical record of the cross sign of 806 CE in the
Anglo-Saxon Chronicle (ASC), which has been considered one of the earliest datable
halo drawings in British records, whereas another cross sign in 776 CE has
been associated with the aurora. However, philological studies have revealed
the later 806 event is derived from continental European annals. Here, records and
drawings for the 806 event have been philologically traced back to mid-ninth-century continental European manuscripts (MSS) and the probable observational site
identified as the area of Sens in northern France. The possible lunar halos
at that time have been comprehensively examined by numerical ray tracing.
Combined with calculations of twilight sky brightness, they identify a
visibility window supporting monastic observation. Cruciform halos are shown
to be fainter and rarer than brighter and more commonplace lunar halos.
Physically credible cloud ice crystal variations can reproduce all the
manuscript renditions. The manuscript records prove less-than-desirable
detail, but what is presented is fully consistent with a lunar-halo
interpretation. Finally, the possible societal impacts of such celestial
events have been mentioned in the context of contemporary coins in
Anglo-Saxon England and the Carolingian Empire. These analyses show that we
need to trace their provenance back as far as possible, to best reconstruct
the original event, even if graphical records are available for given
astronomical/meteorological events.
Critical Thinking and Physics Concepts: Indicators for General Education Science Course Assessment
Authors: Ramlo Susan 
Published: April 2020

Abstract
Demonstrating knowledge of major concepts and critical thinking are common learning outcomes for general education courses, especially in the sciences. Although numerous valid and reliable measures of conceptual understanding exist, the determination of critical thinking level is often more difficult, subjective, and domain-specific. This study investigates the relationship between domain-specific critical thinking and the learning of force and motion concepts within laboratory activities in a first semester, non-calculus college physics course. Regression analyses were used while controlling for age, prior physics coursework, and the conceptual understanding pretest score. Conceptual understanding was measured using the valid and reliable Force and Motion Conceptual Evaluation (FMCE). Critical Thinking (CT) was determined using the Holistic Critical Thinking Scoring Rubric (HCTSR) and the Structure of the Observed Learning Outcomes (SOLO) Taxonomy. The results indicate that students' CT has a significant correlation with their learning of force and motion concepts. In other words, students who demonstrate a Newtonian view of force and motion also demonstrate higher levels of CT. Thus, FMCE post-test scores could be used as a proxy for students' CT measurements within a first semester physics course. Additionally, the preference of the SOLO Taxonomy is based on ease of use and estimates of inter-rater reliability.
Cardiopulmonary Resuscitation: Recent Advances
Authors: Kumar Abhishek , Yadav Pratishtha , Garg Rakesh 
Published: April 2020

Cardiac arrest is the most significant reason for mortality and morbidities worldwide. With a better understanding of the pathophysiology of cardiac arrest, simple adaptations in basic life support to upcoming modifications in post-resuscitation care have been proposed by various resuscitation councils throughout the globe. Role of point of care cardiac ultrasound during cardiopulmonary resuscitation (CPR) has been explored and its contribution for identifying reversible causes and its real time management has been explored. A higher blood and tissue oxygenation levels contributed to an increased rate of return of spontaneous circulation (ROSC) which has to lead us to explore more options to increase the oxygenation. Starting from the CPR training, the use of sensors for spirometric feedback in ventilation maneuvers can help improve the quality of CPR. High flow nasal oxygenation during CPR has shown promising results. Extracorporeal CPR is another entity that has shown survival benefits in a selected group of patients. The aim of the newer advances has always been to decrease the morbidity and improve survival outcomes in terms of neurological deficit as well. These guidelines are reviewed and updated regularly to improve knowledge and training based on the current evidence. This chapter shall focus on recent advances in cardiopulmonary resuscitation.
Mortality by nodavirus in grouper (Epinephelus marginatus L., 1758) from the Cabo de Palos and Islas Hormigas Marine Reserve, Murcia
Authors: Peñalver José , María-Dolores Emilio , García-Charton José Antonio , Martínez Marcelo , Pérez José Javier , Sánchez Miguel Ángel , San Miguel Elena , Rocha Ana , Fernández-Somalo María Pilar 
Published: April 2020

Los nodavirus afectan a gran número de especies de peces, silvestres y cultivadas. En silvestres se ha aislado en diversas especies, pero nunca se había asociado con procesos clínicos en el litoral de Murcia. En otoño de 2017, se detectaron diversos ejemplares de meros (Epinephelus marginatus y E. costae) en la Reserva de Cabo de Palos con sintomatología clínica compatible con nodavirus. La infección por nodavirus fue confirmada mediante RT-PCR en tiempo real y su posterior genotipado (tipo RGNNV). Este hallazgo constituye la primera evidencia regional de infección clínica por nodavirus en peces silvestres, con la relevancia añadida de que la especie afectada es la especie emblemática de la Reserva Marina de Cabo de Palos, el mero.
Nodaviruses affect a large number of fish species, wild and farmed. In the wild it has been isolated in various species, but it had never been associated with clinical processes on the coast of Murcia. In autumn 2017, several specimens of groupers (Epinephelus marginatus and E. costae) were detected in the Cabo de Palos Reserve with clinical symptoms compatible with nodavirus. The infection by nodavirus was confirmed by real time RT-PCR and its subsequent genotyping (RGNNV type). This finding constitutes the first regional evidence of clinical infection by nodavirus in wild fish, with the added relevance that the affected specie, the grouper, is the emblematic specie of the Cabo de Palos Marine Reserve.
Effect of Tuber Size and Intra-row Spacing on Yield and Quality of Potato (Solanum tuberosum L.)
Authors: . Dawinder , Singh Gurbax , Singh Amanpreet , Singh Jagjot 
Published: April 2020

A study was conducted to determine the effect of tuber size and intra row spacing on potato (Solanum tuberosum L.) yield and subsequent growth in the 2017 production season. The experiment was laid out in a 3x4 combination arranged in a split-plot design with three replications (three levels of tuber size: 20-30 mm, 30-40 mm and 40-50 mm and four levels of intra row spacing's: 8, 12, 16 and 20 cm). For the optimum emergence and successful growth of potato tubers for processable yield, a size of 40-50 mm and spacing of 20 cm between plants, respectively were identified as the best treatments to be used in the study area.
Mental Alertness, Self-esteem and Emotional Intelligence of Underprivileged Students: A Remedial Intervention Program
Authors: Maheshbabu N. , Madhushree S. 
Published: April 2020

Aim: To assess the remedial training intervention on mental alertness, self-esteem, emotional intelligence of underprivileged.
Study Design: The present study is experimental design and adopts remedial intervention program.
Place and Duration of Study: Underprivileged students of high school (Bidar district of North Karnataka, India).
Methodology: Underprivileged students of 9th standard were selected from Government high schools located in Bidar district using the purposive sampling technique and in the first phase, the pre-test was conducted and based on the results the intervention program over a period of six months was conducted. Mental alertness scale developed by Srivastava [1] self-esteem scale developed by Prasad Thakur [2] and emotional intelligence developed by Shettal Prasad [3]. The questionnaires were administered in both phases i.e. pre-test and post-test.
Sample: Underprivileged students 120 studying at 9th grade were included both boys and girls.
Results: Paired t-test was used for data analysis and it was found that there is a significant difference in mental alertness, self-esteem and emotional intelligence of underprivileged in post-test; this means remedial intervention training has an effect on students learning process.
Conclusion: The remedial intervention program has an effect on mental alertness, self-esteem and emotional intelligence. Therefore, underprivileged students’ needs special care and attention for their learning process as they are lack in proper parenting style and hence such remedial program can be planned based upon the students’ academic achievements and this should be the major part of the school curriculum for underprivileged.
Developments and Challenges in Self‐Healing Antifouling Materials
Authors: Wang Zhanhua , Scheres Luc , Xia Hesheng , Zuilhof Han 
Published: April 2020

AbstractSelf‐healing antifouling materials have gained rapidly increasing interest over the past decade and have been studied and used in a rapidly increasing range of applications. Recent developments and challenges in self‐healing antifouling materials are summarized in four sections: first, the different mechanisms for both antifouling and self‐healing are briefly discussed. Second, three main categories of self‐healing antifouling materials based on surface replenishing and dynamic covalent and noncovalent interactions are discussed, with a focus on the preparation, characterization, and central characteristics of different self‐healing antifouling materials. Third, different types of potential applications of self‐healing antifouling materials are summarized, such as injectable hydrogels and oil/water separations. Finally, a summary of future development of the field is provided, and a number of critical limitations that are still outstanding are highlighted.
Role of Interlayer in 3D Vertically Aligned Nanocomposite Frameworks with Tunable Magnetotransport Properties
Authors: Sun Xing , Kalaswad Matias , Li Qiang , Paldi Robynne L. , Huang Jijie , Wang Han , Gao Xingyao , Zhang Xinghang , Wang Haiyan 
Published: April 2020

AbstractTo investigate the role of interlayers on the growth, microstructure, and physical properties of 3D nanocomposite frameworks, a set of novel 3D vertically aligned nanocomposite (VAN) frameworks are assembled by a relatively thin interlayer (M) sandwiched by two consecutively grown La0.7Sr0.3MnO3 (LSMO)‐ZnO VANs layers. ZnO nanopillars from the two VAN layers and the interlayer (M) create a heterogeneous 3D frame embedded in the LSMO matrix. The interlayer (M) includes yttria‐stabilized zirconia (YSZ), CeO2, SrTiO3, BaTiO3, and MgO with in‐plane matching distances increasing from ≈3.63 to ≈4.21 Å, and expected in‐plane strains ranging from tensile (≈8.81% on YSZ interlayer) to compressive (≈–6.23% on MgO interlayer). The metal‐insulator transition temperature increases from ≈133 K (M = YSZ) to ≈252 K (M = MgO), and the low‐field magnetoresistance peak value is tuned from ≈36.7% to ≈20.8%. The 3D heterogeneous frames empower excellent tunable magnetotransport properties and promising potentials for microstructure‐enabled applications.
Asymmetric Catalytic 1,2‐Dihydrophosphination of Secondary 1,2‐Diphosphines – Direct Access to Free P*‐ and P*,C*‐Diphosphines
Authors: Teo Ronald Hong Xiang , Chen Houguang Jeremy , Li Yongxin , Pullarkat Sumod A. , Leung Pak‐Hing 
Published: April 2020

AbstractA 1,2‐dihydrophosphination of bis(phenylphosphino)ethane with a wide range of activated olefins was achieved in a catalytic manner with enantiomeric and diastereomeric excess of up to >99% and 44% respectively. The protocol can be extended to selected substrates leading to free P‐ and C‐chiral 1,2‐diphosphines. The synthesized ligands can also undergo direct complexation onto palladium affording complexes with complete retention of stereo‐integrity.magnified image
Emerging Trends in Nanocarbon‐Based Cardiovascular Applications
Authors: Veerubhotla Krishna , Lee Chi H. 
Published: April 2020

AbstractThis review aims to review the biomedical applications of nanocarbons to various cardiovascular devices including implantable scaffolds, patches, and stents against coronary artery diseases (CAD). The clinical applications of nanocarbons in cardiac tissue engineering, cardiomyocyte supporting implants, biosensors for cardiovascular biomarkers, bioimaging and monitoring of pathological conditions of CAD are addressed. In addition, the current challenges in minimizing the toxicity of nanocarbon materials and alleviating techniques are discussed from a clinical perspective. A novel fabrication approach for nanocarbons in cell‐laden cardiovascular stents is a promising regenerative means for the treatment of damaged infarction in CAD.
Hydrogel‐Based Multifunctional Dressing Combining Magnetothermally Responsive Drug Delivery and Stem Cell Therapy for Enhanced Wound Healing
Authors: Zhang Xiaozhang , Tian Conghui , Chen Zhongrong , Zhao Gang 
Published: April 2020

AbstractMultifunctional dressings are attracting increased interest in the area of tissue engineering and regenerative medicine. Wound healing is a dynamic and complex process that requires multidisciplinary management. However, dressings that exhibit both anti‐infective and tissue regenerative properties are still limited. Herein, a hydrogel‐based multifunctional dressing weaved by drug‐loaded magnetothermally responsive [Fe3O4@SiO2‐interpenetrating polymer network (IPN)] microfibers and human umbilical cord mesenchymal stem cell‐laden microfibers is developed. Magnetothermally responsive microfibers, as smart constructs, can release antibiotics on‐demand to prevent infection, due to the magnetothermal heating effect of the embedded magnetic nanoparticles and the thermoresponsive property of the IPN hydrogels. Furthermore, stem cell‐laden microfibers markedly promote cell proliferation and tissue remodeling, with improved re‐epithelization, granulation tissue formation, and collagen deposition at the wound site. Hydrogel‐based microfibers have the additional ability of absorbing exudate, providing a moist environment, and retaining the therapeutic cells. Therefore, functional microfibers and textiles significantly accelerate the healing process. An advanced dressing for wound healing, incorporating controlled drug delivery and stem cell‐based therapy is developed. Furthermore, the results of the present study reveal the potential of multifunctional dressings in tissue engineering and regenerative medicine.
Dual Supramolecular Nanoparticle Vectors Enable CRISPR/Cas9‐Mediated Knockin of Retinoschisin 1 Gene—A Potential Nonviral Therapeutic Solution for X‐Linked Juvenile Retinoschisis
Authors: Chou Shih‐Jie , Yang Peng , Ban Qian , Yang Yi‐Ping , Wang Mong‐Lien , Chien Chian‐Shiu , Chen Shih‐Jen , Sun Na , Zhu Yazhen , Liu Hongtao , Hui Wenqiao , Lin Tai‐Chi , Wang Fang , Zhang Ryan Yue , Nguyen Viet Q. , Liu Wenfei , Chen Mengxiang , Jonas Steve J. , Weiss Paul S. , Tseng Hsian‐Rong , Chiou Shih‐Hwa 
Published: April 2020

AbstractThe homology‐independent targeted integration (HITI) strategy enables effective CRISPR/Cas9‐mediated knockin of therapeutic genes in nondividing cells in vivo, promising general therapeutic solutions for treating genetic diseases like X‐linked juvenile retinoschisis. Herein, supramolecular nanoparticle (SMNP) vectors are used for codelivery of two DNA plasmids—CRISPR‐Cas9 genome‐editing system and a therapeutic gene, Retinoschisin 1 (RS1)—enabling clustered regularly interspaced short palindromic repeats (CRISPR)‐associated protein 9 (CRISPR/Cas9) knockin of the RS1 gene with HITI. Through small‐scale combinatorial screenings, two SMNP vectors, with Cas9 and single guide RNA (sgRNA)‐plasmid in one and Donor‐RS1 and green fluorescent protein (GFP)‐plasmid in the other, with optimal delivery performances are identified. These SMNP vectors are then employed for CRISPR/Cas9 knockin of RS1/GFP genes into the mouse Rosa26 safe‐harbor site in vitro and in vivo. The in vivo study involves intravitreally injecting the two SMNP vectors into the mouse eyes, followed by repeated ocular imaging by fundus camera and optical coherence tomography, and pathological and molecular analyses of the harvested retina tissues. Mice ocular organs retain their anatomical integrity, a single‐copy 3.0‐kb RS1/GFP gene is precisely integrated into the Rosa26 site in the retinas, and the integrated RS1/GFP gene is expressed in the retinas, demonstrating CRISPR/Cas9 knockin of RS1/GFP gene.
The Development of Pseudocapacitor Electrodes and Devices with High Active Mass Loading
Authors: Chen Ri , Yu Miao , Sahu Rakesh P. , Puri Ishwar K. , Zhitomirsky Igor 
Published: April 2020

AbstractPseudocapacitive materials are used for supercapacitor applications due to their exceptionally high capacitance and low cost. Good capacitive performance of the pseudocapacitive materials at high active mass loadings is vital for the development of the next generation of supercapacitor devices. This review describes recent advances in materials and nanotechnologies, which allows the development of advanced pseudocapacitive devices with high active mass. An important breakthrough is the discovery of novel dispersing and capping agents for the colloidal processing of nanoparticles. Particularly important are novel co‐dispersants that exhibit enhanced adsorption on materials of different types, such as inorganic nanoparticles, carbon nanotubes, and graphene. Conceptually new strategies are designed to fabricate coated particles. Recent innovations pave the way for the development of multifunctional redox‐active dopants‐dispersants and dopants‐oxidants to manufacture conductive polymer composites. Among the most important advances in nanotechnology is the development of template methods and heterocoagulation techniques for composite manufacturing. The progress in the design of novel surface modification techniques and materials, discovery of advanced anchoring groups, and development of liquid–liquid extraction allows agglomerate‐free processing of nanomaterials and composites. This review describes fundamental aspects of novel technologies and their applications in the manufacturing of pseudocapacitive devices for energy storage.
High‐Efficiency CsPbI2Br Perovskite Solar Cells with Dopant‐Free Poly(3‐hexylthiophene) Hole Transporting Layers
Authors: Li Ming‐Hua , Liu Shun‐Chang , Qiu Fa‐Zheng , Zhang Zhen‐Yun , Xue Ding‐Jiang , Hu Jin‐Song 
Published: April 2020

AbstractCsPbI2Br is emerging as a promising all‐inorganic material for perovskite solar cells (PSCs) due to its more stable lattice structure and moisture resistance compared to CsPbI3, although its device performance is still much behind this counterpart. Herein, a preannealing process is developed and systematically investigated to achieve high‐quality CsPbI2Br films by regulating the nucleation and crystallization of perovskite. The preannealing temperature and time are specifically optimized for a dopant‐free poly(3‐hexylthiophene) (P3HT)‐based device to target dopant‐induced drastic performance degradation for spiro‐OMeTAD‐based devices. The resulting P3HT‐based device exhibits comparable power conversion efficiency (PCE) to spiro‐OMeTAD‐based devices but much enhanced ambient stability with over 95% PCE after 1300 h. A diphenylamine derivative is introduced as a buffer layer to improve the energy‐level mismatch between CsPbI2Br and P3HT. A record‐high PCE of 15.50% for dopant‐free P3HT‐based CsPbI2Br PSCs is achieved by alleviating the open‐circuit voltage loss with the buffer layer. These results demonstrate that the preannealing processing together with a suitable buffer layer are applicable strategies for developing dopant‐free P3HT PSCs with high efficiency and stability.