bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tendon elongation with bovine pericardium in strabismus surgery—indications beyond Graves’ orbitopathy
Authors: Hedergott Andrea , Pink-Theofylaktopoulos Ursula , Neugebauer Antje , Fricke Julia 
Published: September 2020

Abstract
Background
For some patients with complex ocular motility disorders, conventional strabismus surgery is insufficient. Surgery with tendon elongation allows correction of larger angles and maintains a sufficient arc of contact for rectus muscles. This study reports results for tendon elongation with bovine pericardium (Tutopatch®) in indications other than Graves’ orbitopathy in which it is already widely used.

Methods
We reviewed the records of all patients who underwent surgery with Tutopatch® in our institution. Angles of squint and head postures were analyzed preoperatively, on the first postoperative day, and in the long term (median 9 weeks after the operation). Patients with Graves’ orbitopathy were excluded.

Results
From 2011 to 2018, the procedures on 58 eyes of 54 patients (35 females, median age 35 years (3–75)) met the inclusion criteria. Horizontal rectus muscle surgery (53 eyes) was conducted on patients with residual strabismus (13), Duane’s retraction syndrome with eso- (type I: 16)/exodeviation (type II: 2, type III: 1), 6th (7)/3rd nerve palsy (7), Möbius syndrome (2), congenital fibrosis of the extraocular muscles type 3A (CFEOM3A, TUBB3 mutation) (4), and orbital apex syndrome (1). Vertical rectus muscle surgery (5 eyes) was conducted on patients with myasthenia (1), vertical tropia after orbital floor fracture (1), CFEOM1 (2), and Parry-Romberg syndrome (1). 42 eyes had prior eye muscle surgery (1–5 procedures, median 1). Out of 45 patients with postoperative long-term data, 43 showed an angle reduction. Fifty-one percent had an angle of 10Δ (prism diopter) or less, one had a significant over-effect, and 10 had revision surgery. For the heterogeneous group of residual eso- and exotropias, the median absolute horizontal angle was reduced from 35Δ (16 to 45Δ) to 9Δ (0 to 40Δ), for Duane’s retraction syndrome from 27.5Δ (9 to 40Δ) to 7Δ (0 to 40Δ), and for sixth and third nerve palsies from 43Δ (20 to 75Δ) to 18Δ (4 to 40Δ). For 3 patients with vertical rectus muscle surgery, the median absolute vertical angle was reduced from 30Δ (20 to 45Δ) to 4Δ (1 to 22Δ). The motility range was shifted in the direction contrary to the elongated muscle in all subgroups. A considerable reduction of the excursion into the field of action of the elongated muscle had to be registered.

Conclusions
Strabismus surgery with bovine pericardium introduces new surgical options for complicated revisions and for rare and complex oculomotor dysfunctions. Yet, it has to be recognized that this type of surgery aiming at maximum effects, despite preservation or restitution of the arc of contact, leads to reduction of the excursion into the field of action of the elongated muscle. Furthermore, dose finding can be difficult depending on the underlying pathology and more than one intervention might be necessary for optimal results.
Ultrastructural characterization of microlipophagy induced by the interaction of vacuoles and lipid bodies around generative and sperm cells in Arabidopsis pollen
Authors: Akita Kae , Takagi Tomoko , Kobayashi Keiko , Kuchitsu Kazuyuki , Kuroiwa Tsuneyoshi , Nagata Noriko 
Published: September 2020

AbstractDuring pollen maturation, various organelles change their distribution and function during development as male gametophytes. We analyzed the behavior of lipid bodies and vacuoles involved in lipophagy in Arabidopsis pollen using serial section SEM and conventional TEM. At the bicellular pollen stage, lipid bodies in the vegetative cells lined up at the surface of the generative cell. Vacuoles then tightly attached, drew in, and degraded the lipid bodies and eventually occupied the space of the lipid bodies. Degradation of lipid began before transfer of the entire contents of the lipid body. At the tricellular stage, vacuoles instead of lipid bodies surrounded the sperm cells. The degradation of lipid bodies is morphologically considered microautophagy. The atg2-1 Arabidopsis mutant is deficient in one autophagy-related gene (ATG). In this mutant, the assembly of vacuoles around sperm cells was sparser than that in wild-type pollen. The deficiency of ATG2 likely prevents or slows lipid degradation, although it does not prevent contact between organelles. These results demonstrate the involvement of microlipophagy in the pollen development of Arabidopsis.
Prenatal maternal infections and children’s socioemotional development: findings from the UK Millennium Cohort Study
Authors: Hall Hildigunnur Anna , Speyer Lydia Gabriela , Murray Aja Louise , Auyeung Bonnie 
Published: September 2020

AbstractPrevious research suggests that prenatal maternal infections may be associated with increased odds of children having a neurodevelopmental disorder. However, little evidence exists on associations with broader child outcomes, especially subclinical symptoms. Participants were the N = 14,021 members of the population-representative UK Millennium Cohort Study. We examined associations between prenatal maternal infections, both maternal-reported and hospital-recorded, and children’s socioemotional development, using the Strengths and Difficulties Questionnaire (SDQ) at age three. Maternal-reported prenatal infections were associated with increased emotional symptoms, after adjusting for several potential confounds and covariates. Hospital-recorded prenatal infections were not associated with children’s socioemotional outcomes, after adjusting for potential confounding and covarying factors. Findings suggest that prenatal maternal infections, particularly those which the mothers remember months later, may be associated with increased emotional problems in early childhood. This emphasises the need for screening for and preventing infections during pregnancy. Further, the occurrence of prenatal infection indicates the potential need for early intervention for children’s emotional difficulties.
Mongolian Short-toed Lark Calandrella dukhunensis, an overlooked East Asian species
Authors: Alström Per , Sundev Gombobaatar 
Published: September 2020

AbstractThe eastern subspecies of Greater Short-toed Lark Calandrella brachydactyla dukhunensis has recently been considered a separate species, Calandrella dukhunensis, by several authors based on molecular data. We present supporting evidence for this treatment based on studies of morphology, vocalisations and song-flight, and also present new data on other aspects of its biology based on field studies. We show that its breeding distribution is considerably smaller than previously thought, and is restricted to the eastern half of Mongolia and, marginally, neighbouring parts of China and perhaps Russia.
Social Influence of Competing Groups and Leaders in Opinion Dynamics
Authors: Glass Catherine A. , Glass David H. 
Published: September 2020

AbstractThis paper explores the influence of two competing stubborn agent groups on the opinion dynamics of normal agents. Computer simulations are used to investigate the parameter space systematically in order to determine the impact of group size and extremeness on the dynamics and identify optimal strategies for maximizing numbers of followers and social influence. Results show that (a) there are many cases where a group that is neither too large nor too small and neither too extreme nor too central achieves the best outcome, (b) stubborn groups can have a moderating, rather than polarizing, effect on the society in a range of circumstances, and (c) small changes in parameters can lead to transitions from a state where one stubborn group attracts all the normal agents to a state where the other group does so. We also explore how these findings can be interpreted in terms of opinion leaders, truth, and campaigns.
A Mire of Discount Rates: Delaying Conservation Payment Schedules in a Choice Experiment
Authors: Grammatikopoulou Ioanna , Artell Janne , Hjerppe Turo , Pouta Eija 
Published: September 2020

AbstractStudies on the public’s implicit discount rate in the willingness to pay for environmental amenities have mostly employed contingent valuation surveys. We investigate respondents’ time preferences using choice experiments with four payment schedules in a split-sample design in the context of mire conservation. We first examine preference and taste heterogeneity among respondents, finding them to a large extent independent of payment schedules. Next we use an endogenous approach to jointly estimate the implicit discount rates and preferences using choice experiments data. We explore exponential and hyperbolic discounting model specifications. We find insensitivity to the length of the payment period and support for hyperbolic discounting. Furthermore, we provide policy relevant valuation results concerning mire conservation.
Lake restoration influences nutritional quality of algae and consequently Daphnia biomass
Authors: Taipale S. J. , Kuoppamäki K. , Strandberg U. , Peltomaa E. , Vuorio K. 
Published: September 2020

AbstractFood quality is one of the key factors influencing zooplankton population dynamics. Eutrophication drives phytoplankton communities toward the dominance of cyanobacteria, which means a decrease in the availability of sterols and long-chain polyunsaturated fatty acids (EPA and DHA). The effects of different restoration measures on the nutritional quality of the phytoplankton community and subsequent impacts on zooplankton biomass have rarely been considered. We analyzed the nutritional quality of phytoplankton in the eutrophic Lake Vesijärvi in southern Finland over a 37-year period, and studied the impacts of two restoration measures, biomanipulation and hypolimnetic aeration, on the abundance of high-quality phytoplankton. We found that biomanipulation had a positive impact on the abundance of taxa synthesizing sterols, EPA, and DHA and, concurrently, on the biomass of the keystone species Daphnia. In contrast, hypolimnetic aeration did not result in such a beneficial outcome, manifested as a decrease in the abundance of Daphnia and frequent phytoplankton blooms dominated by cyanobacteria suggesting reduction in the nutritional quality of food for Daphnia. Our analysis shows that the determination of the nutritional value of algae and the contribution of essential fatty acids and sterols is an effective method to evaluate the success of various restoration measures.
A multilayer shallow learning approach to variation prediction and variation source identification in multistage machining processes
Authors: Yacob Filmon , Semere Daniel 
Published: September 2020

AbstractVariation propagation modelling in multistage machining processes through use of analytical approaches has been widely investigated for the purposes of dimension prediction and variation source identification. Yet the variation prediction of complex features is non-trivial task to model mathematically. Moreover, the application of the variation propagation approaches and associated variation source identification techniques using Skin Model Shapes is unclear. This paper proposes a multilayer shallow neural network regression approach to predict geometrical deviations of parts given manufacturing errors. The neural network is trained on a simulated data, generated from machining simulation of a point cloud of a part. Further, given a point cloud data of a machined feature, the source of variation can be identified by optimally matching the deviation patterns of the actual surface with that of shallow neural network generated surface. To demonstrate the method, a two-stage machining process and a virtual part that has planar, cylindrical and torus features was considered. The geometric characteristics of machined features and the sources variation could be predicted at an error of 1% and 4.25%, respectively. This work extends the application of Skin Model Shapes in variation propagation analysis in multistage manufacturing.
Upcycling of Vine Shoots: Production of Fillers for PHBV-Based Biocomposite Applications
Authors: David Grégoire , Heux Laurent , Pradeau Stéphanie , Gontard Nathalie , Angellier-Coussy Hélène 
Published: September 2020

AbstractThis paper aims at investigating the potential of vine shoots (ViSh) upcycling as fillers in novel poly(3-hydroxybutyrate-3-hydroxyvalerate) (PHBV) based biocomposites. ViSh particles of around 50 µm (apparent median diameter) were obtained combining dry grinding processes, and mixed with PHBV using melt extrusion. Thermal stability and elongation at break of biocomposites were reduced with increasing contents of ViSh particles (10, 20 and 30 wt%), while Young’s modulus and water vapor permeability were increased. It was shown that a surface gas-phase esterification allowed to significantly increase the hydrophobicity of ViSh particles (increase of water contact angles from 59° to 114°), leading to a reduction of 27% in the water vapor permeability of the biocomposite filled with 30 wt% of ViSh. The overall mechanical performance was not impacted by gas-phase esterification, demonstrating that the interfacial adhesion between the virgin ViSh particles and the PHBV matrix was already good and that such filler surface treatment was not required in that case. It was concluded that ViSh particles can be interestingly used as low cost fillers in PHBV-based biocomposites to decrease the overall cost of materials.
Optimization and validation of pumping system design and operation for water supply in high-rise buildings
Authors: Müller Tim M. , Leise Philipp , Lorenz Imke-Sophie , Altherr Lena C. , Pelz Peter F. 
Published: September 2020

AbstractThe application of mathematical optimization methods for water supply system design and operation provides the capacity to increase the energy efficiency and to lower the investment costs considerably. We present a system approach for the optimal design and operation of pumping systems in real-world high-rise buildings that is based on the usage of mixed-integer nonlinear and mixed-integer linear modeling approaches. In addition, we consider different booster station topologies, i.e. parallel and series-parallel central booster stations as well as decentral booster stations. To confirm the validity of the underlying optimization models with real-world system behavior, we additionally present validation results based on experiments conducted on a modularly constructed pumping test rig. Within the models we consider layout and control decisions for different load scenarios, leading to a Deterministic Equivalent of a two-stage stochastic optimization program. We use a piecewise linearization as well as a piecewise relaxation of the pumps’ characteristics to derive mixed-integer linear models. Besides the solution with off-the-shelf solvers, we present a problem specific exact solving algorithm to improve the computation time. Focusing on the efficient exploration of the solution space, we divide the problem into smaller subproblems, which partly can be cut off in the solution process. Furthermore, we discuss the performance and applicability of the solution approaches for real buildings and analyze the technical aspects of the solutions from an engineer’s point of view, keeping in mind the economically important trade-off between investment and operation costs.
Power in the ‘Organisation’: A Soft Systems Perspective
Authors: Stowell Frank 
Published: September 2020

AbstractAll systems must adapt in order to survive, this is as true for a business organisation as any other system. A business exists in a turbulent environment and in order to maintain its relationship with its environment its managers have to adapt it to the circumstances. The effect of the present pandemic is an example with some staff working from home, active blended learning in the education sector and social distancing have all created an urgency to accommodate the unprecedented consequence of the situation. To effect the necessary changes that these circumstances have generated means exercising some form of power to change operating procedures. Change creates uncertainty, the threat of the reallocation of resources, delegated power, redundancies and a change in group relationships. This produces a feeling of insecurity in those within the organisation often resulting in resistance to the proposals in an attempt to maintain the status quo. They are faced with adapting or resisting to these changes. Whilst systems models of organisational behavior provide ideas about organizing and managing an enterprise these are of limited value because of the unpredictability of change. The ubiquity of communication technologies and the rise of virtual methods of working add to the pressure for change creating a climate of anxiety. Organisational power can no longer be framed by the measures once taken for granted. To this end I adopt a soft systems perspective to explore the impact of change upon an organisation and how those within react as they attempt to cope with its impact.
From Obesity to Energy Metabolism: Ontological Perspectives on the Metrics of Human Bodies
Authors: Serpico Davide , Borghini Andrea 
Published: September 2020

AbstractIn this paper, we aim at rethinking the concept of obesity in a way that better captures the connection between underlying medical aspects, on the one hand, and an individual’s developmental history, on the other. Our proposal rests on the idea that obesity is not to be understood as a phenotypic trait or character; rather, obesity represents one of the many possible states of a more complex phenotypic trait that we call ‘energy metabolism.’ We argue that this apparently simple conceptual shift can help solve important theoretical misconceptions regarding the genetics, epigenetics, and development of obesity. In addition, we show that our proposal can be fruitfully paired with the concept of developmental channeling of a trait, which connects to the study of the plasticity and canalization of complex traits. Finally, we discuss the potential impact of our approach on the assessment, treatment, and social narratives of obesity.
Ways to get work done: a review and systematisation of simplification practices in the LCA literature
Authors: Beemsterboer Sjouke , Baumann Henrikke , Wallbaum Holger 
Published: September 2020

Abstract
Purpose
Within the field of life cycle assessment (LCA), simplifications are a response to the practical restrictions in the context of a study. In the 1990s, simplifications were part of a debate on streamlining within LCA. Since then, many studies have been published on simplifying LCA but with little attention to systematise the approaches available. Also, despite being pervasive during the making of LCA studies, simplifications remain often invisible in the final results. This paper therefore reviews the literature on simplification in LCA in order to systematise the approaches found today.

Methods
A review of the LCA simplification literature was conducted. The systematic search and selection process led to a sample of 166 publications. During the review phase, the conceptual contributions to the simplification discourse were evaluated. A dataset of 163 entries was created, listing the conceptual contributions to the simplification debate. An empirically grounded analysis led to the generative development of a systematisation of simplifications according to their underlying simplifying logic.

Results and discussion
Five simplifying logics were identified: exclusion, inventory data substitution, qualitative expert judgment, standardisation and automation. Together, these simplifying logics inform 13 simplification strategies. The identified logics represent approaches to handle the complexities of product systems and expectations of the users of LCA results with the resources available to the analyst. Each simplification strategy is discussed with regard to its main applications and challenges.

Conclusions
This paper provides a first systematisation of the different simplification logics frequently applied in LCA since the original streamlining discussion. The presented terminology can help making communication about simplification more explicit and transparent, thus important for the credibility of LCA. Despite the pervasiveness of simplification in LCA, there is a relative lack of research on simplification per se, making further research describing simplification as a practice and analysing simplifications methodologically desirable.
When should a rare inherited connective tissue disorder be suspected in bicuspid aortic valve by primary-care internists and cardiologists? Proposal of a score
Authors: Pepe Guglielmina , Giusti Betti , Colonna Stefania , Fugazzaro Maria Pia , Sticchi Elena , De Cario Rosina , Kura Ada , Pratelli Elisa , Melchiorre Daniela , Nistri Stefano 
Published: September 2020

AbstractSize threshold for aortic surgery in bicuspid aortic valve (BAV) is debated. Connective tissue disorders (CTDs) are claimed as a clinical turning point, suggesting early surgery in BAV patients with CTD. Thus, we aimed at developing a score to detect high risk of carrying CTDs in consecutive BAVs from primary care. Ninety-eight BAVs without ectopia lentis or personal/family history of aortic dissection were studied at the Marfan syndrome Tuscany Referral Center. Findings were compared with those detected in 84 Marfan patients matched for sex and age. We selected traits with high statistical difference between MFS and BAV easily obtainable by cardiologists and primary-care internists: mitral valve prolapse, myopia ≥ 3DO, pectus carenatum, pes planus, wrist and thumb signs, and difference between aortic size at root and ascending aorta ≥ 4 mm. Clustering of ≥ 3 of these manifestations were more frequent in Marfan patients than in BAVs (71.4% vs 6.1%, p < 0.0001) resulting into an Odds Ratio to be affected by MFS of 38.3 (95% confidence intervals 14.8–99.3, p < 0.0001). We propose a score assembling simple clinical and echocardiographic variables resulting in an appropriate referral pattern of BAVs from a primary-care setting to a tertiary center to evaluate the presence of a potential, major CTD.