bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling Rotational Disruption of Grains and Microwave Emission from Spinning Dust in AGB Envelopes
Authors: Tram Le Ngoc , Hoang Thiem , Soam Archana , Lesaffre Pierre , Reach William T. 
Published: April 2020

Abstract
Radio observations of some asymptotic giant branch (AGB) star envelopes show excess emission at frequencies below 100 GHz that cannot be explained by thermal dust emission (hereafter anomalous microwave emission (AME)). Moreover, AGB envelopes are a common place where gas molecules condense to form nanoparticles (e.g., polycyclic aromatic hydrocarbons) and large grains. In this paper, we study whether electric dipole emission from rapidly spinning nanoparticles can reproduce the AME observed toward AGB stars. To properly model the size distribution of nanoparticles in the AGB envelope, we take into account both the increase of nanoparticles due to rotational disruption of large grains spun up by radiative torques and the decrease of the smallest nanoparticles due to rotational disruption driven by stochastic gas collisions. We then perform detailed modeling of microwave emission from rapidly spinning nanoparticles from both C-rich and O-rich AGB envelopes using the grain-size distribution constrained by rotational disruption. We find that spinning dust emission is dominant over thermal dust emission at frequencies below 100 GHz. We attempt to fit the observational data of AME using our spinning dust model and demonstrate that spinning dust can reproduce the observed AME in six AGB stars. Finally, we discuss how microwave emission from spinning dust in AGB envelopes could be observed with high-resolution upcoming radio telescopes such the Next Generation Very Large Array and Atacama Large Millimeter/submillimeter Array Band 1. This would be a major leap for understanding AGB envelopes’ formation, evolution, and internal structures of dust. Observations would help to distinguish the carrier of AME via comparisons of C-rich and O-rich stars, because polycyclic aromatic hydrocarbons (PAHs) are formed in C-rich AGB stars, while silicates are formed in O-rich stars.
L’Encyclopédie des guerres : la « beauté »
Authors: Jouannais Jean-Yves 
Published: April 2020

Depuis 2008, Jean-Yves Jouannais, romancier et critique d’art, cherche, trouve, copie, classe des citations ainsi que tous types d’images ayant trait à la guerre, et constitue avec ce matériau une Encyclopédie des guerres en expansion constante, qu’il lit et commente en public chaque mois. Il livre ici l’entrée « Beauté ».
« Dieu est beau, Il aime la beauté »
Authors: Bencheikh Ghaleb 
Published: April 2020

« Dieu est beau, Il aime la beauté. » Cet aphorisme bien connu du prophète de l’islam a toujours été au centre des préoccupations métaphysiques avec une inclination esthétique des penseurs, philosophes et théologiens musulmans à travers l’histoire. Lorsque les croyants et, par-delà, les acteurs sociaux l’ont médité et intériorisé dans les contextes islamiques, leurs califes et leurs princes ont bâti une civilisation impériale à l’architecture palatiale. Alors le délabrement moral que donnent à voir le rigorisme salafiste et le fanatisme islamiste se présentent comme une inversion tragique du cours de cette civilisation et des cultures qui la sous-tendent. Aussi, la sortie de crise passera-t-elle par la dimension salvifique de la beauté réappropriée. Elle sera le viatique pour une spiritualité vivante et élévatrice. Elle renouera avec l’humanisme et l’épanouissement du sujet humain.
Choc des armes et littérature
Authors: Clain Geoffroy 
Published: April 2020

L’introduction de la guerre hybride, des conflits asymétriques ou la réapparition de la « haute intensité » rappellent que les formes de la bataille sont en perpétuelle évolution. Pourtant, la perception commune du lieu où se déroule cette conflictualité semble figée. Elle oscille entre une posture glorificatrice du champ de Mars, auréolé de mythes, et une position de rejet. L’idée d’une bataille décisive tout autant que les figures cardinales des héros contribuent amplement à entretenir la première version. La seconde a rejeté l’homme de la bataille avec l’avènement des conflits de masse, de l’industrie, plus récemment du sentimentalisme et aujourd’hui de la robotique. Toutefois, ces deux visions ne sont pas exclusives l’une de l’autre. Cet article propose d’observer comment et dans quelles proportions ces deux perceptions du champ de bataille ont été reproduites dans la littérature.
Treatment and control of an outbreak of Salmonellosis in hatchling Nile crocodiles (Crocodylus Niloticus)
Authors: Huchzermeyer K. D.A. 
Published: April 2020

The therapeutic and managemental steps taken to bring a severe outbreak of salmonellosis in Nile crocodiles (Crocodylus niloticus) under control are described. All the crocodiles were initially given intramuscular injections with kanamycin on alternating days for 8 d, coupled with adjustment of the ambient temperature to 29 °C. The holding pens were cleaned and disinfected with 2% formalin at the onset of treatment. Daily scrubbing and disinfection was continued throughout the treatment period. Severely affected crocodiles were separated and force-fed a liquid diet. All crocodiles were vaccinated with an inactivated calf paratyphoid vaccine 10 d after the onset of treatment and again one month later. The initial treatment was followed by a 30-week period of in-feed medication with oxytetracycline. Response to the initial treatment was dramatic, although some mortalities still occurred in the force-fed group for one month. The following year's hatchlings were fed heat-treated meat from first feeding onwards to avoid the possibility of introducing Salmonella spp. via the feed.
Acute Leukemia Presenting with Musculoskeletal Manifestations: A Case Series
Authors: Kesarapu Swetha , Vangala Navatha , Uppin Shantveer G , Uppin Megha S , Paul Tara Roshni , Rajasekhar Liza 
Published: April 2020

Abstract
Introduction: Leukemia is the most common childhood malignancy accounting for 30%–40% of cases. Acute lymphoblastic leukemia is the most common leukemia in children with peak incidence in 2–6 years of age. The present study aims to assess the incidence of acute leukemia in patients presenting with musculoskeletal manifestations. Materials and Methods: This is a retrospective study conducted in a tertiary center from January 2014 to December 2018. A total of 63 children presented with musculoskeletal manifestations and underwent bone marrow examination. Based on final marrow diagnosis, the study group was divided into leukemic and nonleukemic groups. Results: Fever was the most common presenting complaint and was present in all the patients of both the groups. The occurrence of hepatosplenomegaly was comparatively higher in the leukemic group than in patients with juvenile idiopathic arthritis (JIA). The predominant type of arthritis was oligoarticular (68.15%) in the leukemic group and polyarticular (77.27%) in the nonleukemic group. Rheumatoid rash was noted in 20% of JIA patients, and none of the patients in the leukemic group had rash. The percentages of anemia, leukopenia, and thrombocytopenia were statistically higher in leukemia patients than in JIA patients. Conclusion: Bone marrow studies are a prerequisite in diagnosing leukemias. However, based on the presence of few atypical clinical and laboratory features, leukemia can be excluded in JIA patients.
Hereditary Breast and Ovarian Cancer Syndrome (BRCA) Gene: Concept, Pathways, Therapeutics, and Future
Authors: Tamhankar Anup , Tamhankar Tanuja 
Published: April 2020

AbstractHereditary breast and ovarian cancers are most commonly caused by mutations in BRCA1 and 2 genes. These are autosomal dominant mutations with high penetrance into subsequent generations. Affected individuals have deficiency in DNA repair mechanisms such as double strand DNA breaks (DSB) and non-homologous end joining (NHEJ). These tumors are peculiar due to early age of onset, typical histology such as triple negative breast cancers and high grade serous ovarian cancers and exquisite sensitivity to platinum analogues. These patients usually have better survival as compared to their wild type counterparts. Incidence of these mutations is rising due to better awareness about them amongst oncologists and patient population. Various genomic assays are available to detect germline and somatic BRCA mutations. Newer therapeutic frontiers like PARP inhibition have opened up due to better understanding of various mutations and their impact on subsequent pathways. Further studies are required to explore possibility of direct BRCA inhibition which may be useful in treatment of other solid organ cancers as well. This review focuses on understanding the pathophysiology of BRCA mutations, various pathways associated with the same, chemosensitivity patterns amongst affected cancer cells, targeted therapeutic opportunities and potential future developments in this field. We collected data from various published electronic records on google and have no conflicts of interest to be declared.
Miracle in Cancer Care: A Transformative Bond
Authors: Mullapally Sujith Kumar , Jayasree Lekshmy 
Published: April 2020

AbstractThe bond period after formal academic training is many times perceived by residents as an unnecessary barrier, which prevents them from a fabulous career ahead. In this article, a post-DM and post-MD resident shares their experience of bond period at a government cancer center in rural Vizag. They got an opportunity to witness the results of an outstanding vision and unwavering commitment in the field of oncology, especially in the context of lack of adequate infrastructure.
Primary Diffuse Large B-cell Lymphoma of the Breast: Treatment and Long-Term Outcome of Two Cases
Authors: Kashyap Rajesh , Kumar Pradeep , Lal Hira , Rao Ram Naval 
Published: April 2020

AbstractPrimary breast lymphoma (PBL) is a rare form of extranodal non-Hodgkin’s lymphoma (NHL). It accounts for <0.5% of all breast malignancies and 2% extranodal NHL. Diffuse large B-cell lymphoma (DLBCL) is the most common histological subtype. We report three cases of PBL diagnosed and treated at our center. The clinical records of three female patients diagnosed with PBL from 2004 to 2015 were reviewed. Two patients had DLBCL, and the third patient had anaplastic large cell (ALCL) NHL. The mean age at presentation was 56 years. One patient with DLBCL was treated with cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) chemotherapy and the second patient with rituximab plus CHOP chemotherapy. Both the patients showed complete response and have had a disease-free survival of 84 and 96 months, respectively. The third patient with ALCL refused further treatment after confirmation of diagnosis. PBL-DLBCL can be successful treated with chemotherapy, and long-term survival is similar to nodal NHL.
Occupational Therapy’s Value in Provision of Quality Care to Prevent Readmissions
Authors: Roberts Pamela , Robinson Marla , Furniss Jeremy , Metzler Christina 
Published: April 2020

Abstract
Health care systems are prioritizing the quality of outcomes over the quantity of services provided, and health care payers and other stakeholders are focusing on preventing hospital readmissions. This priority supports the effort to reduce the cost of health care by avoiding the most expensive care type and improving the quality of health care by promoting sustained return to the community and remaining in the community. Occupational therapy practitioners have expertise that is critically important in this effort. Occupational therapy places a unique and immediate focus on patients’ functional and social needs, which can be important drivers of readmissions if they are not addressed. By addressing activities of daily living, instrumental activities of daily living, functional cognition, psychosocial needs, vision, fear of falling, and safety, occupational therapy practitioners can be a valuable addition to the effort to keep people out of the hospital and participating in their lives. This article reviews the literature supporting the role of occupational therapy in each of these key areas.
The Pacific–Indian Ocean associated mode in CMIP5 models
Authors: Yang Minghao , Li Xin , Shi Weilai , Zhang Chao , Zhang Jianqi 
Published: April 2020

Abstract. The Pacific–Indian Ocean associated mode (PIOAM), defined as the first dominant mode (empirical orthogonal function, EOF1) of sea surface temperature anomalies (SSTAs) in the Pacific–Indian Ocean between 20∘ S and 20∘ N, is the product of the tropical air–sea interaction at the cross-basin scale and the main mode of ocean variation in the tropics. Evaluating the capability of current climate models to simulate the PIOAM and finding the possible factors that affect the simulation results are beneficial in the pursuit of more accurate future climate change prediction. Based on the 55-year Hadley Centre Global Sea Ice and Sea Surface Temperature (HadISST) dataset and the output data from 21 Coupled Model Intercomparison Project (CMIP) phase 5 (CMIP5) models, the PIOAM in these CMIP5 models is assessed. Instead of using the time coefficient (PC1) of the PIOAM as its index, we chose to utilize the alternative PIOAM index (PIOAMI), defined with SSTA differences in the boxes, to describe the PIOAM. It is found that the explained variance of the PIOAM in almost all 21 CMIP5 models is underestimated. Although all models reproduce the spatial pattern of the positive sea surface temperature anomaly in the eastern equatorial Pacific well, only one-third of these models successfully simulate the El
Niño–Southern Oscillation (ENSO) mode with the east–west inverse phase in the Pacific Ocean. In general, CCSM4, GFDL-ESM2M and CMCC-CMS have a stronger capability to capture the PIOAM than the other models. The strengths of the PIOAM in the positive phase in less than one-fifth of the
models are slightly greater, and very close to the HadISST dataset, especially CCSM4. The interannual variation of the PIOAM can be measured by CCSM4,
GISS-E2-R and FGOALS-s2.
What God Hath Put Together: Hurston, Black Queer Love, and the Act of Creation
Authors: Melton McKinley 
Published: April 2020

ABSTRACTThis discussion considers a literary genealogy that examines Zora Neale Hurston as a predecessor to Joseph Beam and Essex Hemphill, prefiguring their need for a process through which multiply-marginalized communities might create images that more accurately reflect their existence, and considers contemporary poets Danez Smith and Timothy DuWhite as inhabitants of the legacy that they left behind. Focusing primarily on how these artists invoke—and often revise and subvert—the biblical creation narrative within their own narratives of self-creation and image- making, this discussion is also concerned with these writers' articulation of love that is deemed unnatural due to its defiance of heteropatriarchal and cultural norms. These works, when read alongside and in dialogue with one another, collectively assert that love, defined as natural and divinely approved, functions as a challenge to restrictive ideologies and a tool of affirmation for themselves and their communities.
Morphological and anatomical investigation of New Caledonian graminoid Dendrobium (Orchidaceae) with the description of two new species
Authors: Pignal Marc , Munzinger Jérôme 
Published: April 2020

Morphological characters support the description of two new species of Orchidaceae from New Caledonia: Dendrobium butinii M.Pignal & Munzinger sp. nov. and Dendrobium letocartiorum Munzinger & M.Pignal sp. nov. The lectotypes of Dendrobium camaridiorum Rchb.f. and D. crassifolium Schltr. are designated here. A leaf anatomical study was conducted and provided useful characters to distinguish the five New Caledonian graminoid Dendrobiineae species. Two identification tools are provided: an anatomical key for sterile material of grass-like Dendrobiineae and a morphological key for the New Caledonian graminoid Dendrobium. We propose preliminary conservation assessments with IUCN criteria for the new taxa.
Realidade e literatura: ditadura militar chilena, forclusão dos horizontes de expectativa e portas entreabertas
Authors: Godinho Paula 
Published: April 2020

Neste artigo, pretendo fazer uma reflexão sobre a relação entre a antropologia, a história e a literatura e o seu papel na leitura dos processos sociais, a partir de: (1) uma abordagem de duas obras literárias - El Palacio de la Risa (2014), de Germán Marín e Nocturno de Chile (2000), de Roberto Bolaño; (2) dos elementos de terreno de uma visita a um dos locais de detenção clandestina, tortura e extermínio da ditadura chilena (1973-1990); (3) do cinema documental de Patricio Guzmán, Carmen Castillo e Pablo Salas. Através da sugestão conceptual de Daniel Bensaïd, exploro os limites da forclusão dos horizontes da expectativa, atribuível à supressão da ligação ao espaço da experiência, que conduz a uma anemia da razão crítica. Entre a ficção e o real, interrogo o encadeamento do imaginado, do imaginário e da realidade, e exploro a relação com os passados dolorosos, com o papel continuado do medo, bem como a sua superação, através dos mecanismos poderosos da memória colectiva no Chile.Palavras-chave: Antropología. História. Literatura. Forclusão. Chile.
Comparative proteogenomics profiling of non-small and small lung carcinoma cell lines using mass spectrometry
Authors: Wu Jingyu , Hao Zhifang , Ma Chen , Li Pengfei , Dang Liuyi , Sun Shisheng 
Published: April 2020

Background
Evidences indicated that non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC) might originate from the same cell type, which however ended up to be two different subtypes of lung carcinoma, requiring different therapeutic regimens. We aimed to identify the differences between these two subtypes of lung cancer by using integrated proteome and genome approaches.

Methods and Materials
Two representative cell lines for each lung cancer subtype were comparatively analysed by quantitative proteomics, and their corresponding transcriptomics data were obtained from the Gene Expression Omnibus database. The integrated analyses of proteogenomic data were performed to determine key differentially expressed proteins that were positively correlated between proteomic and transcriptomic data.

Result
The proteomics analysis revealed 147 differentially expressed proteins between SCLC and NSCLC from a total of 3,970 identified proteins. Combined with available transcriptomics data, we further confirmed 14 differentially expressed proteins including six known and eight new lung cancer related proteins that were positively correlated with their transcriptomics data. These proteins are mainly involved in cell migration, proliferation, and invasion.

Conclusion
The proteogenomic data on both NSCLC and SCLC cell lines presented in this manuscript is complementary to existing genomic and proteomic data related to lung cancers and will be crucial for a systems biology-level understanding of the molecular mechanism of lung cancers. The raw mass spectrometry data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD015270.
Vaccination of Tilapia against Motile Aeromonas Septicemia: A Review
Authors: Shirajum Monir Md. , Yusoff Sabri Mohd , Mohamad Aslah , Ina-Salwany M. Y. 
Published: April 2020

Abstract
The production of tilapia Oreochromis spp. is rapidly growing throughout the world, but atypical motile aeromonad septicemia (MAS) is a current threat to the tilapia farming industry. The etiological agent of this disease is usually Aeromonas hydrophila. Mortality rates due to MAS are frequently high, resulting in a devastating negative impact on this industry worldwide; therefore, proper control measures regarding both prevention and treatment are necessary. Although vaccines against MAS for tilapia are available, their effectiveness is entirely dependent on the specific strain of problematic bacteria. Until now, whole-cell inactivated A. hydrophila vaccines for tilapia have exhibited the highest level of protection over live attenuated and recombinant vaccines. Among the various vaccine administration systems, only intraperitoneal (i.p.) injections of the A. hydrophila vaccine into tilapia were found to provide prominent immune protection. Vaccine efficacy was primarily measured by using the i.p. injection challenge model and estimating the relative percent survival of the immunized tilapia. Freund's incomplete adjuvant showed to be the most effective for tilapia MAS vaccines. In this review, multiple factors that directly or indirectly influence the efficacy of MAS vaccines for tilapia (adjuvants, challenge models, immunization doses and duration, and size of vaccinated fish) are discussed.
Nonoxidized MXene Quantum Dots Prepared by Microexplosion Method for Cancer Catalytic Therapy
Authors: Li Xuesong , Liu Feng , Huang Dapeng , Xue Ni , Dang Yangyang , Zhang Mengqi , Zhang Leilei , Li Bo , Liu Duo , Wang Lei , Liu Hong , Tao Xutang 
Published: April 2020

AbstractNanocatalysts based on Fenton or Fenton‐like reactions for amplification of intracellular oxidative stress has become a frontier research area of tumor precise therapy. However, the major translational challenges are low catalytic efficiency, poor biocompatibility, and even potential toxicities. Here, a Ti‐based material with excellent biocompatibility is proposed for cancer treatment. The nonoxidized MXene‐Ti3C2Tx quantum dots (NMQDs‐Ti3C2Tx) are successfully prepared by a self‐designed microexplosion method. Surprisingly, it has an apparent inhibitory and killing effect on cancer cells, and excellent biocompatibility with normal cells. Moreover, the suppression rate of NMQDs‐Ti3C2Tx on xenograft tumor models can reach 91.9% without damaging normal tissues. Mechanistically, the Ti3+ of NMQDs‐Ti3C2Tx can react with H2O2 in the tumor microenvironment and high‐efficiently produce excessive toxic hydroxyl radicals to increase tumor microvascular permeability to synergistically kill cancer cells. This work should pave the way for tumor catalytic therapy applications of Ti‐based material as a promising and safer route.
Complement Receptor Targeted Liposomes Encapsulating the Liver X Receptor Agonist GW3965 Accumulate in and Stabilize Atherosclerotic Plaques
Authors: Benne Naomi , Martins Cardoso Renata , Boyle Aimee L. , Kros Alexander , Jiskoot Wim , Kuiper Johan , Bouwstra Joke , Van Eck Miranda , Slütter Bram 
Published: April 2020

AbstractAtherosclerosis is characterized by the retention of lipids in foam cells in the arterial intima. The liver X receptor (LXR) agonist GW3965 is a promising therapeutic compound, since it induces reverse cholesterol transport in foam cells. However, hepatic LXR activation increases plasma and liver lipid levels, inhibiting its clinical development. Herein, a formulation that specifically enhances GW3965 deposition in the atherosclerotic lesion is aimed to be developed. GW3965 is encapsulated in liposomes functionalized with the cyclic peptide Lyp‐1 (CGNKRTRGC), which binds the p32 receptor expressed on foam cells. These liposomes show preferential uptake by foam cells in vitro and higher accumulation in atherosclerotic plaques in mice compared to non‐targeted liposomes as determined by in vivo imaging. Flow cytometry analysis of plaques reveals increased retention of Lyp‐1 liposomes in atherosclerotic plaque macrophages compared to controls (p < 0.05). Long term treatment of established plaques in LDLR ‐/‐ mice with GW3965‐containing Lyp‐1 liposomes significantly reduces plaque macrophage content by 50% (p < 0.01). Importantly, GW3965‐containing Lyp‐1 liposomes do not increase plasma or hepatic lipid content. Thus, GW3965‐containing Lyp‐1 liposomes successfully target the atherosclerotic macrophages allowing plaque stabilization without commonly observed side effects of LXR agonists.