bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diet-induced obesity enhances postprandial glucagon-like peptide-1 secretion in Wistar rats, but not in diabetic Goto-Kakizaki rats
Authors: Pinyo Jukkrapong , Hara Hiroshi , Hira Tohru 
Published: November 2020

AbstractGlucagon-like peptide-1 (GLP-1) is postprandially secreted from enteroendocrine L-cells and enhances insulin secretion. Currently, it is still controversial whether postprandial GLP-1 responses are altered in obesity and diabetes. To address the issue and to find out possible factors related, we compared postprandial GLP-1 responses in normal rats and in diabetic rats chronically fed an obesogenic diet. Male Wistar rats and diabetic Goto-Kakizaki (GK) rats were fed either a control diet or a high-fat/high-sucrose (HFS, 30 % fat and 40 % sucrose) diet for 26 weeks. Meal tolerance tests were performed for monitoring postprandial responses after a liquid diet administration (62·76 kJ/kg body weight) every 4 or 8 weeks. Postprandial glucose, GLP-1 and insulin responses in Wistar rats fed the HFS diet (WH) were higher than Wistar rats fed the control diet (WC). Although GK rats fed the HFS diet (GH) had higher glycaemic responses than GK rats fed the control diet (GC), these groups had similar postprandial GLP-1 and insulin responses throughout the study. Jejunal and ileal GLP-1 contents were increased by the HFS diet only in Wistar rats. Furthermore, mRNA expression levels of fatty acid receptors (Ffar1) in the jejunum were mildly (P = 0·053) increased by the HFS diet in Wistar rats, but not in GK rats. These results demonstrate that postprandial GLP-1 responses are enhanced under an obesogenic status in normal rats, but not in diabetic rats. Failure of adaptive enhancement of GLP-1 response in GK rats could be partly responsible for the development of glucose intolerance.
Effects of guanidinoacetic acid and coated folic acid supplementation on growth performance, nutrient digestion and hepatic gene expression in Angus bulls
Authors: Liu Y. J. , Chen J. Z. , Wang D. H. , Wu M. J. , Zheng C. , Wu Z. Z. , Wang C. , Liu Q. , Zhang J. , Guo G. , Huo W. J. 
Published: November 2020

AbstractTo evaluate the impacts of guanidinoacetic acid (GAA) and coated folic acid (CFA) on growth performance, nutrient digestion and hepatic gene expression, fifty-two Angus bulls were assigned to four groups in a 2 × 2 factor experimental design. The CFA of 0 or 6 mg/kg dietary DM folic acid was supplemented in diets with GAA of 0 (GAA−) or 0·6 g/kg DM (GAA+), respectively. Average daily gain (ADG), feed efficiency and hepatic creatine concentration increased with GAA or CFA addition, and the increased magnitude of these parameters was greater for addition of CFA in GAA− diets than in GAA+ diets. Blood creatine concentration increased with GAA or CFA addition, and greater increase was observed when CFA was supplemented in GAA+ diets than in GAA− diets. DM intake was unchanged, but rumen total SCFA concentration and digestibilities of DM, crude protein, neutral-detergent fibre and acid-detergent fibre increased with the addition of GAA or CFA. Acetate:propionate ratio was unaffected by GAA, but increased for CFA addition. Increase in blood concentrations of albumin, total protein and insulin-like growth factor-1 (IGF-1) was observed for GAA or CFA addition. Blood folate concentration was decreased by GAA, but increased with CFA addition. Hepatic expressions of IGF-1, phosphoinositide 3-kinase, protein kinase B, mammalian target of rapamycin and ribosomal protein S6 kinase increased with GAA or CFA addition. Results indicated that the combined supplementation of GAA and CFA could not cause ADG increase more when compared with GAA or CFA addition alone.
Safety and outcomes of percutaneous tracheostomy in coronavirus disease 2019 pneumonitis patients requiring prolonged mechanical ventilation
Authors: Takhar A , Tornari C , Amin N , Wyncoll D , Tricklebank S , Arora A , Ahmad I , Simo R , Surda P 
Published: November 2020

AbstractObjectivesTracheostomy for coronavirus disease 2019 pneumonitis patients requiring prolonged invasive mechanical ventilation remains a matter of debate. This study analysed the timing and outcomes of percutaneous tracheostomy, and reports our experience of a dedicated ENT–anaesthetics department led tracheostomy team.MethodA prospective single-centre observational study was conducted of patients undergoing tracheostomy, who had been diagnosed with coronavirus disease 2019 pneumonitis, between 21st March and 20th May 2020.ResultsEighty-one patients underwent tracheostomy after a median (interquartile range) of 16 (13–20) days of invasive mechanical ventilation. Median follow-up duration was 32 (23–40) days. Of patients, 86.7 per cent were successfully liberated from invasive mechanical ventilation in a median (interquartile range) of 12 (7–16) days. Moreover, 68.7 per cent were subsequently discharged from hospital. On univariate analysis, there was no difference in outcomes between early (before day 14) and late (day 14 or later) tracheostomy. The mortality rate was 8.6 per cent and no deaths were tracheostomy related.ConclusionOutcomes appear favourable when patients are carefully selected. Percutaneous tracheostomy performed via a multidisciplinary approach, with appropriate training, was safe and optimised healthcare resource utilisation.
Planning considerations prior to laryngectomy for a patient infected with severe acute respiratory syndrome coronavirus-2 pre-operatively
Authors: Coleman H , Tikka T , Okhovat S , Kang S K 
Published: November 2020

AbstractBackgroundCoronavirus disease 2019 was declared a pandemic on 11th March 2020. All non-urgent surgical procedures have been postponed indefinitely. The British Association of Head and Neck Oncology state that only those with treatable head and neck cancer unsuitable for alternative treatment should undergo surgery. This paper details our management of a patient who tested positive for severe acute respiratory syndrome coronavirus-2 days before curative surgery for laryngeal cancer.Case reportBy following British Association of Head and Neck Oncology guidance, a 49-year-old male scheduled for total laryngectomy and bilateral neck dissection for a T3 transglottic squamous cell cancer was pre-operatively identified as an asymptomatic carrier of severe acute respiratory syndrome coronavirus-2. Following 14-day isolation and laboratory proven viral clearance, he underwent successful major surgery. He was managed throughout the peri- and post-operative phases without complications or adverse effects on staff.ConclusionWith careful planning, previous coronavirus disease 2019 positive status should not prevent an individual from undergoing successful total laryngectomy and bilateral neck dissection in a safe and timely manner during the pandemic.
Energy mapping of the genetic code and genomic domains: implications for code evolution and molecular Darwinism
Authors: Klump Horst H. , Völker Jens , Breslauer Kenneth J. 
Published: November 2020

AbstractWhen the iconic DNA genetic code is expressed in terms of energy differentials, one observes that information embedded in chemical sequences, including some biological outcomes, correlate with distinctive free energy profiles. Specifically, we find correlations between codon usage and codon free energy, suggestive of a thermodynamic selection for codon usage. We also find correlations between what are considered ancient amino acids and high codon free energy values. Such correlations may be reflective of the sequence-based genetic code fundamentally mapping as an energy code. In such a perspective, one can envision the genetic code as composed of interlocking thermodynamic cycles that allow codons to ‘evolve’ from each other through a series of sequential transitions and transversions, which are influenced by an energy landscape modulated by both thermodynamic and kinetic factors. As such, early evolution of the genetic code may have been driven, in part, by differential energetics, as opposed exclusively by the functionality of any gene product. In such a scenario, evolutionary pressures can, in part, derive from the optimization of biophysical properties (e.g. relative stabilities and relative rates), in addition to the classic perspective of being driven by a phenotypical adaptive advantage (natural selection). Such differential energy mapping of the genetic code, as well as larger genomic domains, may reflect an energetically resolved and evolved genomic landscape, consistent with a type of differential, energy-driven ‘molecular Darwinism’. It should not be surprising that evolution of the code was influenced by differential energetics, as thermodynamics is the most general and universal branch of science that operates over all time and length scales.
The development of constructions from the right edge: a multinomial regression analysis of clitic left and right dislocation in child French
Authors: JOURDAIN Morgane , LAHOUSSE Karen 
Published: November 2020

AbstractThe aim of the present research is to investigate the development of left and right dislocation in child French through a corpus study of three children until age 2;7 from the corpus of Lyon (Demuth & Tremblay, 2008). We extracted a total of 704 dislocations and analysed their syntactic properties. We show that (i) right dislocations are more frequent than left dislocations and (ii) left dislocations are significantly more complete than right dislocations (fewer omissions of verbs or pronouns). We compare these results to the hypothesis of Freudenthal, Pine, Jones & Gobet (2015, 2016) according to which some properties of child language can be explained by a learning mechanism from the right edge of the sentences from the input. We will show that this hypothesis can explain the general trend found in our data, but it is not sufficient to account for the entire development of dislocation in French.
A meta-analysis of the effects of treatments used to break dormancy in seeds of the megagenusAstragalus(Fabaceae)
Authors: Soltani Elias , Baskin Jerry M. , Baskin Carol C. , Benakashani Fatemeh 
Published: November 2020

AbstractAstragalusis the largest genus of seed plants with 3000 or more species that occurs naturally on several continents. The genus has some use as a forage and medicine and in industry, and many of the species are rare endemics threatened with extinction. The seeds are reported to be dormant at maturity, and various treatments have been used in an attempt to germinate them. Our primary aim was to determineviaa meta-analysis the most effective way(s) to break dormancy in seeds of this species-rich genus. Mechanical and chemical (conc. sulphuric acid) scarification were by far the best of 12 treatments for breaking seed dormancy of the 40 species included in our meta-analysis, whereas prechilling, gibberellin and smoke were ineffective. These results along with those of imbibition tests confirm that seeds of the examinedAstragalusspecies have physical dormancy (PY). Further, PY in these 40 species and (its documented occurrence) in 118 species that could not be included in our meta-analysis transcends climatic and geographic boundaries, edaphic conditions, life cycle/life form types and infrageneric phylogeny. Thus, it seems likely that most species ofAstragalushave PY. However, in addition to PY, physiological dormancy (PD), that is, combinational dormancy (PY + PD), has been reported in a few species ofAstragalus. This study should be useful to both basic and applied scientists who want to germinate seeds ofAstragalus.
How best to describe the pharyngeal arch arteries when the fifth arch does not exist?
Authors: Anderson Robert H. , Bamforth Simon D. , Gupta Saurabh Kumar 
Published: November 2020

AbstractIn the accompanying article appearing in this issue of the Journal, Prabhu and his colleagues, from Bengalaru in India, describe their experience with patients having a right aortic arch. They discuss the fact that the anomalous arrangements they encountered can all be interpreted on the basis of the hypothetical double arch proposed by Edwards. They point to the fact that interpretation of the developmental changes underscoring the production of the double arch is currently confused by reference to the so-called Rathke diagram, in which six sets of arteries are shown extending through the mesenchyme of the pharyngeal arches. As the authors point out, Graham and his associates have now shown that the alleged fifth set of pharyngeal arches do not exist. Based on our own observations, we endorse this statement. It means that new explanations must now be provided for the lesions previously described on the basis of persistence of the alleged artery of the fifth pharyngeal arch. We have previously claimed to have observed such an artery in a human fetus. We now believe, on the basis of our latest findings, that our earlier observation is better explained on the basis of presence of a collateral channel. We suggest that the so-called “fifth arch arteries” are themselves then best explained either on the basis of existence of such collateral channels, or remodelling of the aortic sac, which is the manifold, during development, that gives rise to the pharyngeal arch arteries.
Delayed picture naming in the first and second language
Authors: Broos Wouter P. J. , Bencivenni Alice , Duyck Wouter , Hartsuiker Robert J. 
Published: November 2020

AbstractSecond language (L2) speakers produce speech more slowly than first language (L1) speakers. This may be due to a delay in lexical retrieval, but it is also possible that the delay is situated at later stages. This study used delayed picture naming to test whether late production stages (leading up to articulation) are slower in L2 than in L1. Dutch–English unbalanced bilinguals performed a regular and a delayed picture naming task in English and Dutch. Monolingual English controls performed these tasks in English. Speakers were slower when naming pictures in L2 during regular picture naming but not in delayed naming. Reaction time costs of using L2 did not vary with phonological complexity, but there was a larger L2 cost in accuracy with more complex words. We conclude that the very last stages prior to articulation are not significantly slower when bilinguals name pictures in their L2.
Alcohol consumption among students and its relationship with nutritional intake: a cross-sectional study
Authors: Hillesund Elisabet R , Øverby Nina C , Valen Erlend L , Engeset Dagrun 
Published: November 2020

AbstractObjective:Excessive alcohol consumption during reproductive years may impact the integrity of developing eggs and sperm, potentially affecting the life-long health of future children. Inadequate diets could aggravate these preconception effects of alcohol. The aim of the present study was to assess the prevalence of excessive alcohol consumption and explore whether weekly alcohol intake is associated with energy and nutrient intake and adequacy of micronutrient intake among students.Design:Cross-sectional survey using a validated and reproducibility-tested FFQ.Setting:University of Agder, Norway, in 2018.Participants:622 students (71 % female).Results:More than 80 % reported having consumed alcoholic beverages the past 4 weeks. One-third of men and 13 % of women exceeded the upper recommended limit of 14 UK alcohol units/week. An inverse association between increasing alcohol intake and energy-adjusted micronutrient intake was evident for thiamine, phosphate, Fe, Zn and Se in men, and for vitamin A,β-carotene, vitamin E and C, thiamine, vitamin B6, folate, P, Mg, K, Fe, Zn and Cu in women. A substantial proportion had vitamin D, folate, Fe and I intakes below average requirement regardless of alcohol consumption level. The combination of prevalent alcohol use, decreasing micronutrient density of diet across alcohol consumption level and a high probability of micronutrient inadequacy indicate reason for concern in a preconception public health perspective.Conclusions:Our findings call for investigations into young adults’ knowledge, reflections and beliefs regarding diet and alcohol use to understand how these behaviours could be improved ahead of parenthood.
Effects of fall bearing-year glufosinate applications, spring nonbearing-year glufosinate applications, and spring nonbearing-year foramsulfuron applications on hair fescue (Festuca filiformis) in lowbush blueberry
Authors: White Scott N. , Zhang Linshan 
Published: November 2020

AbstractHair fescue is a common perennial grass that reduces yields in lowbush blueberry fields. This grass is suppressed with nonbearing-year foramsulfuron applications, though suppression may be improved through use of sequential glufosinate and foramsulfuron applications. The objective of this research was to determine the main and interactive effects of fall bearing-year glufosinate applications, spring nonbearing-year glufosinate applications, and spring nonbearing-year foramsulfuron applications on hair fescue. The experiment was a 2 by 2 by 2 factorial arrangement of fall bearing-year glufosinate application (0, 750 g ai ha–1), spring nonbearing-year glufosinate application (0, 750 g ai ha–1), and spring nonbearing-year foramsulfuron application (0, 35 g ai ha–1) arranged in a randomized complete block design at lowbush blueberry fields located in Parrsboro and Portapique, NS, Canada. Fall bearing-year glufosinate applications, spring nonbearing-year glufosinate applications, and spring nonbearing-year foramsulfuron applications alone provided inconsistent hair fescue suppression. Fall bearing-year glufosinate applications followed by spring nonbearing-year foramsulfuron applications, however, reduced nonbearing-year total tuft density, flowering-tuft density, and flowering-tuft inflorescence number at each site and reduced seed production at Portapique. Sequential fall bearing-year and spring nonbearing-year glufosinate applications or sequential spring nonbearing-year glufosinate and foramsulfuron applications reduced flowering-tuft density and flowering-tuft inflorescence number at each site but did not consistently reduce total tuft density. Sequential herbicide treatments reduced bearing-year seedling density and may therefore contribute to hair fescue seed bank management in lowbush blueberry.
Tribalism in America: Behavioral Experiments on Affective Polarization in the Trump Era
Authors: Whitt Sam , Yanus Alixandra B. , McDonald Brian , Graeber John , Setzler Mark , Ballingrud Gordon , Kifer Martin 
Published: November 2020

AbstractOur research speaks to the ongoing debate over the extent and severity of partisan political divisions in American society. We employ behavioral experiments to probe for affective polarization using dictator, trust, and public goods games with party identification treatments. We find that subjects who identify politically with the Democratic or Republican Party and ideologically as liberals and conservatives display stronger affective biases than politically unaffiliated and ideological moderates. Partisan subjects are less altruistic, less trusting, and less likely to contribute to a mutually beneficial public good when paired with members of the opposing party. Compared to other behavioral studies, our research suggests increasing levels of affective polarization in the way Americans relate to one another politically, bordering on the entrenched divisions one commonly sees in conflict or post-conflict societies. To overcome affective polarization, our research points to inter-group contact as a mechanism for increasing trust and bridging political divides.
Integrating Magnetotelluric and Seismic Images of Silicic Magma Systems: A Case Study From the Laguna del Maule Volcanic Field, Central Chile
Authors: Cordell Darcy , Unsworth Martyn J. , Lee Benjamin , Díaz Daniel , Bennington Ninfa L. , Thurber Clifford H. 
Published: November 2020

AbstractImaging silicic systems using geophysics is challenging because many interrelated factors (e.g., temperature, melt fraction, melt composition, geometry) can contribute to the measured geophysical anomaly. Joint interpretation of models from multiple geophysical methods can better constrain interpretations of the subsurface structure. Previously published resistivity and shear wave velocity (Vs) models, derived separately from magnetotelluric (MT) and surface wave seismic data, respectively, have been used to model the restless Laguna del Maule Volcanic Field, central Chile. The Vs model contains a 450 km3 low‐velocity zone (LVZ) interpreted as a region with an average melt fraction of 5–6%. The resistivity model contains a conductor (C3) interpreted as a region with a melt fraction >35%. The spatial extents of the LVZ and C3 overlap, but the geometries and interpretations of these features are different. To resolve these discrepancies, this study investigates the resolution of the MT data using hypothesis testing and constrained MT inversions. It is shown that the MT data are best fit with discrete conductors embedded within the larger LVZ. The differences between the MT and seismic models reflect resolution differences between the two data sets as well as varying sensitivities to physical properties. The MT data are sensitive to smaller volumes of extractable mush that contain well‐connected crystal‐poor melt (C3). The seismic data have lower spatial resolution but image the full extent of the poorly connected crystal‐rich magma storage system. The combined images suggest that the LdMVF magma plumbing system is thermally heterogeneous with coexisting zones of warm and cold storage.
Infrared Observations of Ganymede From the Jovian InfraRed Auroral Mapper on Juno
Authors: Mura A. , Adriani A. , Sordini R. , Sindoni G. , Plainaki C. , Tosi F. , Filacchione G. , Bolton S. , Zambon F. , Hansen C. J. , Ciarniello M. , Brooks S. , Piccioni G. , Grassi D. , Altieri F. , Migliorini A. , Moriconi M. L. , Noschese R. , Cicchetti A. 
Published: November 2020

AbstractThe Jovian InfraRed Auroral Mapper (JIRAM) on board the NASA Juno spacecraft is a dual‐band imager and spectrometer in the 2–5 μm range with 9‐nm spectral sampling, primarily designed to study the Jovian atmosphere and aurorae. In addition to these goals, JIRAM is used to obtain images and spectra of the Galilean satellites, every time the spacecraft attitude is favorable. Here we present JIRAM images and spectra of Ganymede obtained during the first 4 years of the mission. In particular, on 26 December 2019, during a relatively close passage of Juno with the moon, a dedicated reorientation of the spacecraft was performed to achieve optimized observations of Ganymede by Juno's remote sensing instruments, including JIRAM. In the outbound phase of the flyby, observing the northern polar regions of Ganymede at a distance of roughly 100,000 km, JIRAM collected infrared images and spectra of the surface at a spatial resolution as high as 23 km per pixel, covering high northern latitudes that were scarcely mapped previously. A photometric model of Ganymede reflectance is produced, which diverges from the Lambert model. The spatial distribution of the obtained spectra complements the available coverage of the surface, with particular regard to the 2.0‐µm water ice absorption band and, to a lesser extent, to the 4.26‐µm spectral feature diagnostic of CO2 trapped in water ice. The water ice distribution is compatible with sputtered‐induced water ice grain enrichment at high latitude (>45°). Several minor species (hydrated salts, trapped H2, CO2, and acids) are also identified in the measured spectra.