bluuebunny/crossref_metadata_2025_split huggingface dataset:
Education and devices to prevent blood and body fluid exposures
Authors: Cheetham S , Ngo H , Liira J , Lee E , Pethrick C , Andrews A , Liira H 
Published: December 2019

Abstract

Background
Healthcare workers are at risk of blood and body fluid exposures (BBFE) while delivering care to patients. Despite recent technological advances such as safety-engineered devices (SEDs), these injuries continue to occur in healthcare facilities worldwide.

Aims
To assess the impact of an education and SEDs workplace programme on rates of reported exposures.

Methods
A retrospective cohort study, utilizing interrupted time series analysis to examine reported exposures between 2005 and 2015 at a 600-bed hospital in Perth, Western Australia. The hospital wards were divided into four cohorts.

Results
A total of 2223 records were available for analysis. The intervention was most effective for the first cohort, with significant improvements both short-term (reduction of 12 (95% CI 7–17) incidents per 1000 full-time equivalent (FTE) hospital staff) and long-term (reduction of 2 (CI 0.6–4) incidents per 1000 FTE per year). Less significant or consistent impacts were observed for the other three cohorts. Overall, the intervention decreased BBFE exposure rates at the hospital level from 19 (CI 18–20) incidents per 1000 FTE pre-intervention to 11 (CI 10–12) incidents per 1000 FTE post-intervention, a 41% reduction. No exposures resulted in a blood-borne virus infection.

Conclusions
The intervention was most effective in reducing exposures at a time when incidence rates were increasing. The overall effect was short-term and did not further reduce an already stabilized trend, which was likely due to improved safety awareness and practice, induced by the first cohort intervention.
Social and spatial networks in labour markets
Authors: Topa Giorgio 
Published: December 2019

AbstractSocial connections and referrals are ubiquitous in the labour market, both on the job-seeker side and on the employer side. This article reviews recent developments in the study of referrals, highlighting what we have learned regarding the use and impact of referrals on various labour market outcomes and pointing out the increasingly nuanced picture we are gaining on the effects of referrals. It then discusses directions for future research, emphasizing the importance of using newly available data (and combinations of datasets) and of making tighter connections with the burgeoning macro-labour research that is based on a search and matching framework. Finally, it evaluates the role of referrals from the point of view of policy-makers, discussing their social welfare implications and ways in which they could be explicitly incorporated into various labour market policies. The importance of tighter collaboration between policy-makers, researchers, employers and practitioners is stressed, to conduct more rigorous experimentation and evaluation of potential referral-based policies and programmes.
The Implications of Lineage-Specific Rates for Divergence Time Estimation
Authors: Carruthers Tom , Sanderson Michael J , Scotland Robert W 
Published: December 2019

Abstract
Rate variation adds considerable complexity to divergence time estimation in molecular phylogenies. Here, we evaluate the impact of lineage-specific rates—which we define as among-branch-rate-variation that acts consistently across the entire genome. We compare its impact to residual rates—defined as among-branch-rate-variation that shows a different pattern of rate variation at each sampled locus, and gene-specific rates—defined as variation in the average rate across all branches at each sampled locus. We show that lineage-specific rates lead to erroneous divergence time estimates, regardless of how many loci are sampled. Further, we show that stronger lineage-specific rates lead to increasing error. This contrasts to residual rates and gene-specific rates, where sampling more loci significantly reduces error. If divergence times are inferred in a Bayesian framework, we highlight that error caused by lineage-specific rates significantly reduces the probability that the 95% highest posterior density includes the correct value, and leads to sensitivity to the prior. Use of a more complex rate prior—which has recently been proposed to model rate variation more accurately—does not affect these conclusions. Finally, we show that the scale of lineage-specific rates used in our simulation experiments is comparable to that of an empirical data set for the angiosperm genus Ipomoea. Taken together, our findings demonstrate that lineage-specific rates cause error in divergence time estimates, and that this error is not overcome by analyzing genomic scale multilocus data sets. [Divergence time estimation; error; rate variation.]
Influence of ractopamine hydrochloride and days on feed on feedlot performance and red meat yield in thin cull beef cows targeted for a lean market
Authors: DeClerck Jonathan C , Lucherk Loni W , Reeves Nathan R , Miller Mark F , Bernhard Bryan C , Rathmann Ryan J 
Published: December 2019

AbstractThin, beef, cull cows [n = 144; initial body weight (BW) = 465.8 ± 56.9 kg, initial body condition score (BCS) = 2.13 ± 0.68] were serially slaughtered to evaluate the relationship between ractopamine hydrochloride (RH) administration and days on feed (DOF) on feedlot performance and carcass cutout value in a lean cow market. Cows were organized into a 3 × 2 factorial arrangement of treatments (48 pens, 8 pens per treatment, 3 cows per pen) and blocked by BW nested within pregnancy status. Treatment pens were top-dressed 400 mg per cow per day of RH (Actogain 45; Zoetis, Parsippany, NJ) for the final 28 d prior to slaughter to cows spending 28, 42, or 56 DOF. Pen served as the experimental unit, for all calculations. No RH × DOF interactions were detected (P ≥ 0.11), indicating that despite a majority of compensatory gain occurring during the first 28 d of the trial, the magnitude of the RH response was not affected by DOF. Compared to controls, RH incited improvements in feedlot performance, but had a greater extent on carcass weight gain and efficiency. Specifically, RH improved average daily gain (ADG) by 13.7% (P = 0.04) and carcass ADG by 16.9% (P = 0.02) Cattle fed RH displayed a 15.5% improved gain to feed ratio (P = 0.02) and a 20% improved carcass gain to feed ratio (P = 0.05). Inclusion of RH in the finishing diet increased hot carcass weight by 4.5% (P = 0.05; 12.9 kg). However, supplementation of RH did not alter red meat yield (P ≥ 0.16), but provoked a 11.1% improvement in lean maturity (P &lt; 0.01). Evaluation of the main effect of DOF provided insight into the compensatory state of beef cull cows on a high-concentrate diet. Serial slaughter offal weights presented confounding results. With additional DOF, a numerical increase in liver weights (P = 0.20) suggested that organ tissue replenishment occurred throughout the trial, and cattle experienced compensatory gain during the entire feeding phase. In contrast, lung and heart weights were not altered, while kidney tended to decrease linearly (P = 0.08) despite additional DOF. Furthermore, extending DOF generated a linear increase in dry matter intake (P &lt; 0.01) yet a tendency for a decline in ADG (P = 0.10), reinforcing the premise that most of compensatory gain occurred during the first 28 d of the trial. If thin (BCS ≤ 4), healthy candidates can be finished, feeders can reap the benefits of an additive relationship between compensatory gain and RH.
Avian and serpentine endogenous foamy viruses, and new insights into the macroevolutionary history of foamy viruses
Authors: Aiewsakun Pakorn 
Published: December 2019

Abstract
This study reports and characterises two novel distinct lineages of foamy viruses (FVs) in the forms of endogenous retroviruses (ERVs). Several closely related elements were found in the genome of oriental stork (Ciconia boyciana) and other was found in the genome of spine-bellied sea snake (Hydrophis hardwickii), designated ERV-Spuma.N-Cbo (where 'N' runs from one to thirteen) and ERV-Spuma.1-Hha, respectively. This discovery of avian and serpentine endogenous FVs adds snakes, and perhaps more crucially, birds to the list of currently known hosts of FVs, in addition to mammals, reptiles, amphibians, and fish. This indicates that FVs are, or at least were, capable of infecting all major lineages of vertebrates. Moreover, together with other FVs, phylogenetic analyses showed that both of them are most closely related to mammalian FVs. Further examination revealed that reptilian FVs form a deep paraphyletic group that is basal to mammalian and avian FVs, suggesting that there were multiple ancient FV cross-class transmissions among their hosts. Evolutionary timescales of various FV lineages were estimated in this study, in particular, the timescales of reptilian FVs and that of the clade of mammalian, avian, and serpentine FVs. This was accomplished by using the recently established time-dependent rate phenomenon models, inferred using mainly the knowledge of the co-speciation history between FVs and mammals. It was found that the estimated timescales matched very well with those of reptiles. Combined with the observed phylogenetic patterns, these results suggested that FVs likely co-speciated with ancient reptilian animals, but later jumped to a protomammal and/or a bird, which ultimately gave rise to mammalian and avian FVs. These results contribute to our understanding of FV emergence, specifically the emergence of mammalian and avian FVs, and provide new insights into how FVs co-evolved with their non-mammalian vertebrate hosts in the distant past.
Four-step Augmentation Mastopexy: Lift and Augmentation at Single Time (LAST)
Authors: Ono Marcelo T. , Karner Bruno M. 
Published: December 2019

Background:
Augmentation mastopexy is one of the most difficult challenges plastic surgeons face, especially concerning sustainability of upper pole fullness and lower pole ptosis correction. We describe our technique for augmentation mastopexy that provides inferolateral muscular support for the implant and standardizes a sequence of surgical stages to resolve multiple situations and present the outcomes of patients who underwent such an approach.

Methods:
Our technique proposes the following: (a) modified subpectoral pocket, with muscular inferolateral support for the implant; (b) independent approaches to the submuscular (implant) pocket and parenchymal resection/reshaping; and (c) pre-established 4-step surgical sequence. Data from office files of our private practice were collected for 266 patients who underwent the technique from October 2015 to January 2019. Patient perception about esthetic outcomes, photographs from multiple postoperative follow-ups, and surgical complications/reoperation rates were analyzed.

Results:
Overall mid-term and long-term results (39 months) were positive for lift and augmentation at single time mastopexy; >90% of patients reported satisfaction with their esthetic outcomes, including absence of ptosis. No major complications occurred. The total revision rate was 16%, but it became <5% in 2018 as the learning curve progressed.

Conclusions:
Augmentation mastopexy is complex, and the myriad of approaches and possibilities may cause confusion when selecting the most suitable one. The 4-step sequence provides a reliable option, offering a predefined execution plan, whereas inferolateral muscular support prevents recurrence of lower pole ptosis. Other surgeons’ experience with lift and augmentation at single time mastopexy and further studies are necessary to validate these findings.
When the Mesh Goes Away: An Analysis of Poly-4-Hydroxybutyrate Mesh for Complex Hernia Repair
Authors: Messa Charles A. , Kozak Geoffrey , Broach Robyn B. , Fischer John P. 
Published: December 2019

Background:
Mesh reinforcement is a cornerstone of modern ventral hernia repair (VHR); yet, complications with synthetic mesh and cost of biologic have created a need for alternative options. Biosynthetic mesh is a resorbable scaffold that theoretically leverages the benefits and minimizes deficiencies of existing mesh types. This study evaluates 2-year outcomes following poly-4-hydroxybutyrate (P4HB) mesh reinforcement for complex VHR.

Methods:
A retrospective review of all consecutive VHR with P4HB (n = 70) was conducted from 2015 to 2018 by a single surgeon. Clinical outcomes, quality of life (QoL; and cost were assessed.

Results:
Seventy patients were included with an average age and body mass index of 58.6 years and 33 kg/m2, respectively. High-risk comorbidities included hypertension (59%), and smoking history (50%). Cases were primarily modified Ventral Hernia Working Group class 2 (50%), or 3 (36%), with average defect size of 323 cm2 (25–972 cm2). P4HB was placed in the retromuscular (80%) or onlay (20%) plane. Mean follow-up was 24 months (12.2–41 months). Hernia recurrence rate was 5.7% (n = 4) and occurred an average of 285 days (209–368 days) post-repair. Of the 21 surgical site occurrences (SSO), 5 (7%) required surgical intervention. A significant improvement in overall QoL (P = 0.001) was noted following repair. Defect size and SSOPI were independently associated with increased direct cost.

Conclusions:
P4HB mesh for complex VHR is associated with favorable 2-year clinical outcomes, acceptable hernia recurrence rate, and a significant improvement in QoL. This study supports the use of biosynthetic mesh as an effective biomaterial for complex VHR.
The Advantages and Disadvantages of Medication-Assisted Treatment in Primary Care Offices
Authors: Padgett Tonja M. 
Published: December 2019

Abstract
Substance use disorder (SUD), more specifically opioid use disorder, is a national epidemic. Although there is an emphasis on treatment and increasing treatment locations, there continues to be a gap between the number of people with SUD and the number of treatment centers. To help narrow this gap, some primary care clinicians started providing medication-assisted treatment (MAT) on an outpatient basis in their offices. This option enables clinicians to provide treatment in their own communities, which increases access to treatment and decreases costs. It also enables the clinician and the person with SUD/opioid use disorder to build a relationship, which many clinicians believe is the foundation of successful treatment. The clinician, whether a doctor, a physician assistant, or an advanced practice nurse, has to obtain a Drug Addiction Treatment Act 2000 waiver to provide MAT beyond naltrexone, which has a required educational program and includes a limitation on the number of clients. Conversely, a possible drawback to this type of treatment is the potential for the disruption of continuity of care with regard to psychotherapy treatment. Federal law mandates that therapy is available and provided to people receiving MAT. The clinician may not be able to provide this service and would need to refer the person with SUD for psychotherapy treatment. It may be clinically significant for a type of follow-up communication to be implemented so that the clinician and the therapy provider can maximize SUD treatment success.
Assessment Protocol for Older Adults With Substance Use
Authors: McRae Kenneth R. 
Published: December 2019

AbstractThis quality improvement project focuses on geriatric syndromes in patients 55 years and older admitted to a Minnesota substance abuse treatment center. Age-specific assessments identify abnormal conditions or geriatric syndromes, which prompt earlier nursing and medical interventions. Nursing staff attended a training program that focused on older adults and the use of the Fulmer SPICES tool for patients over the age of 55 years. Pretest and posttest scores showed a positive change in nursing knowledge with an increase in mean test scores of 10.32 (SD= 1.763) to 12.81 (SD= 1.545),p= .000. A 2-month preimplementation and postimplementation chart audit identified changes in assessment findings using the SPICES tool with an increase in adverse outcomes (1.03%) including sleep problems in 75.4% (n= 43) of the target population.
Perceptions and Experiences of Methadone Maintenance Treatment
Authors: Jeske Courtney Pearson , O’Byrne Patrick 
Published: December 2019

Abstract
Over the past 10 years, there has been a consistent increase in opioid use, which has resulted in an increase in methadone maintenance treatment (MMT). With retention in MMT being a key factor, to understand the process of retention, it is important to better understand individual perceptions and experiences. Little research in Ottawa, Ontario, has addressed the perspective of MMT from people enrolled in MMT; therefore, nursing-based research was undertaken. The objective was to understand the process and experiences associated with MMT from the perspective of persons who are enrolled in treatment. Twelve participants were engaged in semistructured interviews. These participants described that, although MMT can positively affect the people who use such a treatment option, multiple barriers, including social perceptions, physical environment, and healthcare delivery practices, continue to affect MMT initiation and delivery.
Mobile Phone Addiction Among Children and Adolescents
Authors: Sahu Maya , Gandhi Sailaxmi , Sharma Manoj Kumar 
Published: December 2019

Abstract

Objectives
Mobile phone addiction among children and adolescents has become a concern for all. To date, focuses have been given to Internet addiction, but comprehensive overview of mobile phone addiction is lacking. The review aimed to provide a comprehensive overview of mobile phone addiction among children and adolescents.

Methods
Electronic databases search included Medline, Proquest, Pubmed, EBSCO host, EMBASE, CINAHL, PsycINFO, OVID, Springer, Wiley online library, and Science Direct. Inclusion criteria were studies including children and adolescents, studies published in peer-reviewed journals, and studies focusing on mobile phone addiction or problematic use of mobile phone. A systematic search identified 12 descriptive studies, which met inclusion criteria, but no interventional study met the criteria.

Results
The prevalence of problematic mobile phone use was found to be 6.3% in the overall population (6.1% among boys and 6.5% among girls), whereas another study found 16% among the adolescents. The review finds that excessive or overuse of mobile phone was associated with feeling insecurity; staying up late at night; impaired parent–child relationship; impaired school relationships; psychological problems such as behavioral addiction like compulsive buying and pathological gambling, low mood, tension and anxiety, leisure boredom, and behavioral problems, among which most pronounced association was observed for hyperactivity followed by conduct problems and emotional symptoms.

Conclusions
Though mobile phone use helps in maintaining social relationship, mobile phone addiction among children and adolescents needs urgent attention. Interventional studies are needed to address these emerging issues.
The effect of emphysema on survival in patients with idiopathic pulmonary fibrosis: A retrospective study in Taiwan
Authors: Lai Ruay-Sheng , Chen Chiu-Fan , Chu Kuo-An , Lin Min-Hsi 
Published: December 2019

Background:
Idiopathic pulmonary fibrosis (IPF) is a rare and chronic fibrosing interstitial lung disease. However, the clinical features and outcomes of IPF in Taiwan have not been well studied. In addition, the survival difference between patients with IPF alone and combined pulmonary fibrosis and emphysema (CPFE) remains controversial.

Methods:
Patients diagnosed with IPF between 2006 and 2016 were retrospectively enrolled in this study. IPF was defined according to the 2011 American Thoracic Society/European Respiratory Society guideline. The clinical features, comorbidities, and outcomes of CPFE group and IPF-alone group were compared. The extents of emphysema and fibrosis were evaluated.

Results:
In total, 114 patients with IPF were enrolled, and 86.8% of them were men with a mean age of 77.8 years. The median survival was 3.33 years in all patients with IPF. Moreover, 30 patients (26.3%) met the CPFE criteria. The CPFE group had a higher percentage of smokers (90% vs 50%, p < 0.001), higher forced vital capacity (82% vs 59%, p < 0.001), and lower fibrosis scores (8.5 ± 2.9 vs 10 ± 3.2, p = 0.022) than did the IPF-alone group. The baseline room air saturation and percentage of pulmonary hypertension were similar between the two groups. The survival time was not significantly different between the CPFE and IPF-alone groups (median survival, 3.58 vs 2.39 years, p = 0.163). In the multivariate analysis, higher fibrosis score, room air saturation < 90%, and lung cancer were significant factors associated with mortality.

Conclusion:
Our study showed that emphysema had no significant effect on the survival of patients with IPF. The outcome of IPF was mainly determined by the baseline disease severity and other comorbidities.
Barriers to implementing clinical trials on nonpharmacological treatments in developing countries: lessons learnt from addressing pain in HIV
Authors: Parker Romy , Madden Victoria J. , Devan Dershnee , Cameron Sarah , Jackson Kirsty , Kamerman Peter , Reardon Cameron , Wadley Antonia 
Published: December 2019

Abstract
Pain affects over half of the people living with HIV/AIDS (LWHA), and pharmacological treatment has limited efficacy. Preliminary evidence supports nonpharmacological interventions. We previously piloted a multimodal intervention in amaXhosa women LWHA and chronic pain in South Africa with improvements seen in all outcomes, in both intervention and control groups. A multicentre, single-blind randomised controlled trial with 160 participants recruited was conducted to determine whether the multimodal peer-led intervention reduced pain in different populations of both male and female South Africans LWHA. Participants were followed up at weeks 4, 8, 12, 24, and 48 to evaluate effects on the primary outcome of pain, and on depression, self-efficacy, and health-related quality of life. We were unable to assess the efficacy of the intervention due to a 58% loss to follow-up (LTFU). Secondary analysis of the LTFU found that sociocultural factors were not predictive of LTFU. Depression, however, did associate with LTFU, with greater severity of depressive symptoms predicting LTFU at week 8 (P = 0.01). We were unable to evaluate the effectiveness of the intervention due to the high LTFU and the risk of retention bias. The different sociocultural context in South Africa may warrant a different approach to interventions for pain in HIV compared with resource-rich countries, including a concurrent strategy to address barriers to health care service delivery. We suggest that assessment of pain and depression need to occur simultaneously in those with pain in HIV. We suggest investigation of the effect of social inclusion on pain and depression.