bluuebunny/crossref_metadata_2025_split huggingface dataset:
Living with young onset dementia: reflections on recent developments, current discourse, and implications for policy and practice
Authors: Mayrhofer Andrea M. , Shora Shaheen , Tibbs Margaret-Anne , Russell Sarah , Littlechild Brian , Goodman Claire 
Published: May 2020

AbstractRecent research on young onset dementia (formal diagnosis at age <65) evidences emerging work around pre-diagnosis, diagnosis and the need to improve post-diagnostic support for this group. An increased awareness of young onset dementia has led to the establishment of peer-support groups, support networks and the involvement of people affected by dementia in research. However, the need to join up services at the systems level persists. Third-sector organisations that offer post-diagnostic support at the community level rely heavily on volunteers. Implications for policy and practice are that community-based commissioning of integrated services between health care, social care and the third sector would go a long way to providing the continuity and stability required in dementia support and care along the illness trajectory. This discussion document was written in collaboration with diagnostic services, the charity sector and conversations with people living with, and affected by, dementia.
Chinese Telecommunications Companies in Ethiopia: The Influences of Host Government Intervention and Inter-firm Competition
Authors: Fei Ding 
Published: May 2020

AbstractThis article examines Chinese engagement in Ethiopia's telecommunications sector. It argues that while theories of developmental state and global production networks contribute important insights on the roles of state agency and inter-firm relations in the rise of global lead firms from East Asia, they are insufficient to interpret the recent overseas ventures of Chinese companies in Africa. A case study of one flagship Chinese telecommunications company in Ethiopia advances the existing literature by highlighting the influences of host government intervention and inter-firm competition in shaping firms’ local operations. Specifically, this article analyses a myriad of changes in the case company's organizational structure and business practices in response to increased market competition administered by the Ethiopian government. Findings reveal that despite benefiting from official inter-state cooperation, Chinese overseas companies are neither static nor merely state-driven players but are flexible in adjusting strategies to improve their competitiveness in the local market.
Validation of a Questionnaire for Family Physicians: Knowledge, Attitude, Practice on Dementia Care
Authors: Arsenault-Lapierre Genevieve , Sourial Nadia , Pakzad Sarah , Hardouin Marine , Couturier Yves , Bergman Howard , Vedel Isabelle 
Published: May 2020

ABSTRACTOur study objective was to develop and validate a questionnaire assessing the knowledge, attitude, and practice (KAP) of family physicians regarding dementia care and dementia strategies in Canada. Using a multistage process with a panel of experts, we developed and distributed an 83-item questionnaire to 542 eligible family physicians in 42 interdisciplinary primary care teams participating in the Quebec Alzheimer Plan implementation. Altogether, 369 physicians (68%) returned questionnaires. Median item-specific non-response rate was 0.8 per cent (0.3%–8.1%). Exploratory factor analyses and scale correlation supported the questionnaire validity. The final questionnaire contained five factors and 31 items. The KAP questionnaire has proved to be a reliable instrument for assessing the KAP of family physicians regarding dementia care and dementia strategies. This questionnaire provides researchers, clinicians, managers, and decision-makers with a tool to assess an intervention, a program, or a policy change implemented in primary health care for patients with dementia.
Understanding trajectories of externalizing problems: Stability and emergence of risk factors from infancy to middle adolescence
Authors: Kjeldsen Anne , Nes Ragnhild Bang , Sanson Ann , Ystrom Eivind , Karevold Evalill Bølstad 
Published: May 2020

AbstractDespite considerable efforts to understand the processes that underlie the development of externalizing behavior problems, it is still unclear why externalizing problems remain chronically high for some children, emerge early and cease by late childhood for others, and arise in adolescence in some cases. The purpose of this study was to examine how a wide range of child and family risk factors are linked to trajectories of externalizing behavior and how these relationships vary from infancy to middle adolescence. We used data from the community-based Norwegian Tracking Opportunities and Problems (TOPP) study sample (n = 921). A Cholesky factorization model was specified to separate stable and emerging risk doses across four developmental periods (infancy, early and middle childhood, and middle adolescence). Children in the High Stable class were characterized by substantially elevated risk levels in multiple domains throughout the study period. Children in the High Childhood Limited class had very high levels of temperamental emotionality, internalizing symptoms, and maternal mental distress, suggesting a substantial intrinsic emotional basis for their externalizing problems. Intrinsic factors seemed less salient for the Adolescent Onset class. These findings emphasize the need for a dynamic perspective on risk factors and support the importance of prevention and intervention efforts across multiple domains from early childhood and throughout adolescence.
THE TEMPLE OF QUETZALCOATL, TEOTIHUACAN: NEW DATA ON THE ORIGINS OF THE SACRIFICIAL VICTIMS
Authors: Price T. Douglas , Spence Michael W. , Longstaffe Fred J. 
Published: May 2020

AbstractContinuing isotopic investigation of the sacrificial burials and trophies beneath the Feathered Serpent Pyramid (Temple of Quetzalcoatl) in ancient Teotihuacan, Mexico, has produced new results. Isotopic proveniencing using bioapatite strontium and structural carbonate oxygen isotopes in tooth enamel was applied to 39 samples, 24 from the sacrificial victims and 15 from the trophy jaws. Both the strontium and oxygen isotope ratios suggest that most or all of the sacrificial victims came from the central highlands of Mexico, which includes the area of Teotihuacan. In this sense, we find somewhat less multiethnicity represented among the military at Teotihuacan than previously thought. Analysis of carbon isotope ratios in enamel structural carbonate indicated a childhood diet dominated by maize, relatively homogeneous among the victims at the pyramid, and typical for much of pre-Hispanic Mesoamerica.
Aetiological evaluation of chest pain in childhood and adolescence
Authors: Aygun Emre , Aygun Sibel Tugce , Uysal Taciser , Aygun Fatih , Dursun Hasan , Irdem Ahmet 
Published: May 2020

AbstractBackground:Chest pain, as a common cause of hospital admissions in childhood, necessitates detailed investigations due to a wide range of differential diagnoses. In this study, we aimed to determine the distribution of diseases causing chest pain in children and investigate the clinical characteristics of children with chest pain.Methods:This study included 782 patients aged between 3 and 18 years who presented to a paediatric cardiology outpatient clinic with chest pain between April 2017 and March 2018. Aetiological causes and demographic features of the patients were analysed.Results:Most prevalent causes of chest pain were musculoskeletal system (33%) and psychogenic (28.4%) causes. Chest pain due to cardiac reasons was seen in eight patients (1%). Diseases of musculoskeletal and gastrointestinal systems and psychogenic disorders were significantly more common in male and female patients, respectively (p < 0.001 for all). In winter, patients’ age and the number of patients with ≥12 years were higher than those in other seasons (p < 0.001). Most of the parents (70.8%) and patients (90.2%) thought that chest pain in their children was caused by cardiac causes.Conclusion:Most of the diagnoses for chest pain in childhood period are benign and include the musculoskeletal system and psychogenic diseases. Although chest pain due to cardiac diseases is rare, a comprehensive analysis of medical history, detailed physical examination and cardiac imaging with echocardiography is needed to reach more accurate diagnoses.
Compression versus traditional machine learning classifiers to detect code-switching in varieties and dialects: Arabic as a case study
Authors: Tarmom Taghreed , Teahan William , Atwell Eric , Alsalka Mohammad Ammar 
Published: May 2020

AbstractThe occurrence of code-switching in online communication, when a writer switches among multiple languages, presents a challenge for natural language processing tools, since they are designed for texts written in a single language. To answer the challenge, this paper presents detailed research on ways to detect code-switching in Arabic text automatically. We compare the prediction by partial matching (PPM) compression-based classifier, implemented in Tawa, and a traditional machine learning classifier sequential minimal optimization (SMO), implemented in Waikato Environment for Knowledge Analysis, working specifically on Arabic text taken from Facebook. Three experiments were conducted in order to: (1) detect code-switching among the Egyptian dialect and English; (2) detect code-switching among the Egyptian dialect, the Saudi dialect, and English; and (3) detect code-switching among the Egyptian dialect, the Saudi dialect, Modern Standard Arabic (MSA), and English. Our experiments showed that PPM achieved a higher accuracy rate than SMO with 99.8% versus 97.5% in the first experiment and 97.8% versus 80.7% in the second. In the third experiment, PPM achieved a lower accuracy rate than SMO with 53.2% versus 60.2%. Code-switching between Egyptian Arabic and English text is easiest to detect because Arabic and English are generally written in different character sets. It is more difficult to distinguish between Arabic dialects and MSA as these use the same character set, and most users of Arabic, especially Saudis and Egyptians, frequently mix MSA with their dialects. We also note that the MSA corpus used for training the MSA model may not represent MSA Facebook text well, being built from news websites. This paper also describes in detail the new Arabic corpora created for this research and our experiments.
Migration of treatment planning system using existing commissioned planning system
Authors: Tolakanahalli Ranjini , Paliwal Bhudatt , Tewatia Dinesh 
Published: May 2020

AbstractIntroduction:Commissioning of a new planning system involves extensive data acquisition which can be onerous involving significant clinic downtime. This could be circumvented by extracting data from existing treatment planning system (TPS) to speed up the process.Material and methods:In this study, commissioning beam data was obtained from a clinically commissioned TPS (Pinnacle™) using Matlab™ generated Pinnacle™ executable scripts to commission an independent 3D dose verification TPS (Eclipse™). Profiles and output factors for commissioning as required by Eclipse™ were computed on a 50 × 50 × 50 cm3water phantom at a dose grid resolution of 2 mm3. Verification doses were computed and compared to clinical TPS dose profiles based on TG-106 guidelines. Standard patient plans from Pinnacle™ including intensity modulated radiation therapy and volumetric modulated arc therapy were re-computed on Eclipse™ TPS while maintaining the same monitor units. Computed dose was exported back to Pinnacle for comparison with the original plans. This methodology enabled us to alleviate all ambiguities that arise in such studies.Results:Profile analysis using in-house software showed that for all field sizes including small multi-leaf collimator-generated fields, >95% of infield and penumbra data points of Eclipse™ match Pinnacle™ generated and measured profiles with 2%/2 mm gamma criteria. Excellent agreement was observed in the penumbra regions, with >95% of the data points passing distance to agreement criteria for complex C-shaped and S-shaped profiles. Dose volume histograms and isodose lines of patient plans agreed well to within a 0·5% for target coverage.Findings:Migration of TPS is possible without compromising accuracy or enduring the cumbersome measurement of commissioning data. Economising time for commissioning such a verification system or for migration of TPS can add great QA value and minimise downtime.
Money Talks: Finance, War, and Great Power Politics in the Nineteenth Century
Authors: Shea Patrick E. 
Published: May 2020

AbstractFinance is often considered a constraining or compelling force in war. This article examines an alternative role of finance in war, asserting that investors can inform states about adversarial intentions and resolve under certain conditions. This signaling mechanism can reduce information asymmetry between states and decrease the probability of conflict. In the context of these theoretical expectations, I examine the case of Austria and the Rothschild Bank in the nineteenth century. I find that instead of being a constraining force on Austrian foreign policy, the Rothschilds helped inform Austria and other European powers during interstate crises. The information provided by the Rothschilds helped Europe avert war in several cases during the nineteenth century.
Ocean Color Algorithms for Estimating Chlorophyll a, CDOM Absorption, and Particle Backscattering in the Arctic Ocean
Authors: Lewis K. M. , Arrigo K. R. 
Published: May 2020

AbstractAs the Arctic Ocean (AO) is increasingly altered by anthropogenic climate change, it is critical that we accurately assess ongoing changes in its capacity to support marine life. Ocean color remote sensing provides an effective tool to estimate phytoplankton biomass and net primary production in the remote and undersampled AO. However, standard algorithms have been parameterized using global data sets that severely underrepresent the AO. Because the optical properties of AO waters differ markedly from those of lower‐latitude waters, standard algorithms perform poorly in the AO. Here, we use the largest bio‐optical database ever assembled for AO waters to examine seasonal and regional patterns of AO optical properties and to quantify their impact on ocean color algorithms. We find that the standard algorithms fail to accurately retrieve the primary photosynthetic pigment chlorophyll a (Chl a) in the AO; it is overestimated at low phytoplankton biomass due to exceptionally high absorption of colored dissolved organic matter (CDOM), particularly on the interior shelves, and underestimated at high biomass due to the photoacclimation of phytoplankton growing in low light leading to high pigment packaging effect. Using this large bio‐optical database that includes in situ measurements from across the AO and through the entire growing season, we parameterize a new empirical (AOReg.emp) and semianalytical (AO.GSM) algorithm which represent the unique bio‐optical properties of the AO to successfully retrieve Chl a, CDOM absorption, and particle backscattering with better accuracy than any algorithm yet applied to the AO.
Surface Depression and Wetland Water Storage Improves Major River Basin Hydrologic Predictions
Authors: Rajib Adnan , Golden Heather E. , Lane Charles R. , Wu Qiusheng 
Published: May 2020

AbstractSurface water storage in small yet abundant landscape depressions—including wetlands and other small waterbodies—is largely disregarded in conventional hydrologic modeling practices. No quantitative evidence exists of how their exclusion may lead to potentially inaccurate model projections and understanding of hydrologic dynamics across the world's major river basins. To fill this knowledge gap, we developed the first‐ever major river basin‐scale modeling approach integrating surface depressions and focusing on the 450,000‐km2 Upper Mississippi River Basin (UMRB) in the United States. We applied a novel topography‐based algorithm to estimate areas and volumes of ~455,000 surface depressions (>1 ha) across the UMRB (in addition to lakes and reservoirs) and subsequently aggregated their effects per subbasin. Compared to a “no depression” conventional model, our depression‐integrated model (a) improved streamflow simulation accuracy with increasing upstream abundance of depression storage, (b) significantly altered the spatial patterns and magnitudes of water yields across 315,000 km2 (70%) of the basin area, and (c) provided realistic spatial distributions of rootzone wetness conditions corresponding to satellite‐based data. Results further suggest that storage capacity (i.e., volume) alone does not fully explain depressions' cumulative effects on landscape hydrologic responses. Local (i.e., subbasin level) climatic and geophysical drivers and downstream flowpath‐regulating structures (e.g., reservoirs and dams) influence the extent to which depression storage volume in a subbasin causes hydrologic effects. With these new insights, our study supports the integration of surface depression storage and thereby catalyzes a reassessment of current hydrological modeling and management practices for basin‐scale studies.
The Impact of Wettability and Surface Roughness on Fluid Displacement and Capillary Trapping in 2‐D and 3‐D Porous Media: 1. Wettability‐Controlled Phase Transition of Trapping Efficiency in Glass Beads Packs
Authors: Geistlinger Helmut , Zulfiqar Bilal 
Published: May 2020

AbstractFluid invasion, displacement of one fluid by another in porous media, is important in a large number of industrial and natural processes. Of special interest is the trapping of gas and oil clusters. We study the impact of wettability on fluid pattern formation and capillary trapping in three‐dimensional glass beads packs (dmean = 1 mm) during fluid invasion at capillary numbers of 10−7 using μ‐CT. The invading fluid was water, and the defending fluid was air. The contact angle of the glass beads was altered between 5° and 115° using Piranha cleaning and silanization. We analyzed the front morphology of the invading fluid, the residual gas saturation, the fluid occupation frequency of pores, and the morphology and statistics of the trapped gas clusters. We found a sharp transition (crossover) at a critical contact angle θc = 96°. Below θc the morphology of the displacement front was flat and compact caused by the strong smoothing effect of cooperative filling. Above θc the morphology of the displacement front was fractal and ramified caused by single bursts (Haines jumps). Across this dynamical phase transition the trapping efficiency changes from no trapping to maximal trapping. For θ > θc the experimental results show that invasion percolation governs the fluid displacement. Strong indicators are the universal scaling behavior of the size distribution of large clusters (relative data error εdata < 1%) and their linear surface‐volume relationship (R2 = 0.99).
Drought‐Induced Soil Desiccation Cracking Behavior With Consideration of Basal Friction and Layer Thickness
Authors: Zeng Hao , Tang Chao‐Sheng , Cheng Qing , Zhu Cheng , Yin Li‐Yang , Shi Bin 
Published: May 2020

AbstractDrought‐induced cracking of soils is of great concern with the advent of global climate change. The cracking process accelerates the evaporation rate of pore water, lowers the water retention capacity, and degrades the hydraulic‐mechanical properties of soils. Basal friction and layer thickness are two important aspects affecting the subsurface cracking. To explore their detailed effects on soils under drying, we conduct a series of desiccation tests on twelve slurry soil bars and select four types of base materials with different roughness levels and three kinds of layer thicknesses. We track the dynamic cracking process in various samples and adopt the noncontact optical technique—digital image correlation—for the motion of soil particles. Experimental results validate that the coupled effects of basal conditions and soil layer thickness play a key role in governing the soil cracking behavior. The presence of rough bottom surface induces the onset and propagation of desiccation cracks at both top and bottom surfaces. Some of the cracks initiated at the bottom do not propagate through the soil profile. Increasing layer thickness weakens the effect of basal friction on the soil top surface shrinkage but increases the frictional force acting on the base and results in more crack initiations at the bottom. The digital image correlation results further reveal that cracks initiated on the bottom surface and propagated upward vertically are dominated by tensile stresses, while those propagated upward obliquely are dominated by the joint action of shear and tensile stresses.
The β-catenin/TCF-4-LINC01278-miR-1258-Smad2/3 axis promotes hepatocellular carcinoma metastasis
Authors: Huang Wei-Juan , Tian Xiao-Peng , Bi Si-Xue , Zhang Si-Rui , He Ting-Sha , Song Li-Yan , Yun Jing-Ping , Zhou Zhong-Guo , Yu Rong-Min , Li Mei 
Published: May 2020

AbstractHepatocellular carcinoma (HCC) metastasis is largely responsible for HCC-associated recurrence and mortality. We aimed to identify metastasis-related long non-coding RNAs (lncRNAs) to understand the molecular mechanism of HCC metastasis. We first identified that miR-1258 was downregulated in HCC tissues both in The Cancer Genome Atlas (TCGA) and Sun Yat-sen University Cancer Center (SYSUCC) dataset. MiR-1258 expression negatively correlated with recurrence-free survival and overall survival of HCC patients. MiR-1258 overexpression inhibited migration and invasion of HCC cells both in vitro and in vivo, whereas miR-1258 downregulation promoted cell metastasis. Luciferase assays verified direct binding of miR-1258 to Smad2 and Smad3, thereby attenuating TGF-β/Smad signaling. We further established that lncRNA LINC01278 was a negative regulator of miR-1258. In vivo and in vitro assays demonstrated that LINC01278-mediated HCC metastasis was dependent on miR-1258 expression. Furthermore, miR-1258 downregulation in turn increased LINC01278 expression. We also observed that TCF-4 could bind to the LINC01278 promoter site. In addition, LINC01278 downregulation decreased migration and invasion of HCC cells induced by β-catenin and TGF-β1 both in vitro and in vivo. We uncovered a novel mechanism for β-catenin/TCF-4-LINC01278-miR-1258-Smad2/3 feedback loop activation in HCC metastasis, and the study indicated that LINC01278 could serve as a therapeutic target for HCC metastasis.
Analysis of different characteristics of smile
Authors: Khan Mehwish , Kazmi Syed Murtaza Raza , Khan Farhan Raza , Samejo Imran 
Published: May 2020

AbstractIntroductionAnalysis of smile is imperative in the diagnosis and treatment planning phases of aesthetic dentistry.AimTo evaluate the components of smile among students of a dental institution.MethodsFrontal view digital photographs with posed smile of 157 dental students were assessed using Adobe Photoshop7.0. Smile characteristics evaluated included; smile line, smile arc, smile design, upper lip curvature, labiodental relationship and number of teeth displayed. Data were analyzed using SPSS version 23.0. Pearson chi-square test was used to determine the gender based differences for various parameters.ResultsAverage smile line (43.3%), consonant smile arcs (45.2%), cuspid smiles (45.9%), upward lip curvature (43.9%), maxillary anterior teeth not covered by lower lip (60.5%) and teeth displayed up to first premolars (35.7%). Gender based differences were not statistically significant except for smile arc (pvalue = 0.02) and number of teeth displayed (pvalue < 0.001). There was a significant relationship between lip curvature and smile pattern (pvalue < 0.001) and lip curvature and smile arc (pvalue = 0.01) revealing that upward lip curvature was associated with commissure type smiles and consonant smile arcs.ConclusionsThe smile characteristics should be considered before beginning the aesthetic treatment of the patient to obtain adequate results in oral rehabilitation.