bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic segregation for male body coloration and female mate preference in the guppy
Authors: Sato Aya , Kawata Masakado 
Published: January 2020

Abstract
Objective
The purpose of this study was to segregate the genetic lines responsible for the orange area of coloration in males and the response to orange coloration exhibited by females in the guppy (Poecilia reticulata) through artificial selection. This study is part of a project that uses QTL-seq to search for candidate genes involved in male orange coloration and female response to male coloration. We created two lines: high-selected lines of males having large areas of orange spots and of females with high response to male orange coloration; and low-selected lines of males having small areas of orange spots and of females with low response to male orange coloration.

Results
The male orange area and the female response became significantly different between high- and low-selected lines after three generations of artificial selection. This indicates that the differences in the frequencies of alleles at loci affecting the orange area and the female response between the lines increased over the generations through selection.
Body image of people over 50 in Spain measured using the BSQ test
Authors: Sánchez-Cabrero Roberto , Martínez-López Fernando , Euán-Ramírez Reyna Guadalupe 
Published: January 2020

Abstract
Objectives
To show the body image of people over 50 in Spain using the Body Shape Questionnaire test (BSQ), taking into account attribute variables of great interest such as age, gender, sentimental status, habitat (rural or urban) and the season of the year in which the test is done (winter or summer).

Data description
The results obtained show the current state of the body image of 176 people in the process of ageing in Spain. The data collected from the participants are organised taking into account attribute variables of significant impact on body image such as age, gender, having a stable partner, habitat (rural or urban) and the season of the year in which the test is done (winter or summer). These data are especially useful to show how body image changes over the time, depending on the different attributes and according to diverse emotional and social situations. They can be used in studies on body image, eating disorders or studies that assess the importance of physical appearance in someone’s self-esteem regardless of age group, geographic area or personal emotional circumstances.
Does overweight before pregnancy reduce the occurrence of gastroschisis?: the Japan Environment and Children’s Study
Authors:   The Japan Environment and Children’s Study Group, Michikawa Takehiro , Yamazaki Shin , Suda Eiko , Kuroda Tatsuo , Nakayama Shoji F. , Isobe Tomohiko , Kobayashi Yayoi , Iwai-Shimada Miyuki , Sekiyama Makiko , Kawamoto Toshihiro , Nitta Hiroshi 
Published: January 2020

AbstractObjectiveFor several observational studies that have reported the factors related to gastroschisis, the target population in these studies was mainly residents of Europe or the US, and there is little data on the Asian population. In this study, we summarised characteristics of Japanese women who delivered infants with gastroschisis, particularly focusing on the pre-pregnancy body mass index (BMI), which was found to be inversely associated with gastroschisis in past studies, because the distribution of BMI is clearly different in Asia and the West.ResultsWe used data from a nationwide birth cohort study which recruited pregnant women between 2011 and 2014. Among 92,796 women who delivered singleton live births, the frequency of underweight (pre-pregnancy BMI < 18.5 kg/m2) was 16.2%, reference weight (18.5–24.9 kg/m2) 73.1%, and overweight (≥ 25.0 kg/m2) 10.6%. We identified only 9 infants with gastroschisis, 2 of whose women were underweight (frequency of gastroschisis = 0.01%), 5 were in the reference group (0.01%), and 2 were overweight (0.02%). Of these 9 women, none were aged < 20 years, 2 were aged 20–29 years (frequency = 0.01%), and 7 were aged 30–39 years (0.01%). No reduction in the occurrence of gastroschisis was apparent among Japanese women who were overweight before pregnancy.
A simple approximated solution method for solving fractional trust region subproblems of nonlinearly equality constrained optimization
Authors: Zhu Honglan , Ni Qin , Zhang Xuebing 
Published: January 2020

AbstractIn this paper, a fractional model is used to solve nonlinearly constrained optimization problems. In order to solve the fractional trust region subproblems simply, we propose an approximated solution method by cyclically fixing the fractional coefficient part of the approximate function. The global convergence of the fractional trust region method is proved, and the numerical results show that the new algorithm is effective and stable.
Ten-year resistance trends in pathogens causing healthcare-associated infections; reflection of infection control interventions at a multi-hospital healthcare system in Saudi Arabia, 2007–2016
Authors: Balkhy Hanan H. , El-Saed Aiman , Alshamrani Majid M. , Alsaedi Asim , Al Nasser Wafa , El Gammal Ayman , Aljohany Sameera M. , Almunif Sara , Arabi Yassen , Alqahtani Saad , Bonnie Henry Baffoe , Alghoribi Majed , Alothman Adel , Almohrij Saad A. 
Published: January 2020

AbstractBackgroundStudying temporal changes in resistant pathogens causing healthcare-associated infections (HAIs) is crucial in improving local antimicrobial and infection control practices. The objective was to describe ten-year trends of resistance in pathogens causing HAIs in a tertiary care setting in Saudi Arabia and to compare such trends with those of US National Health Surveillance Network (NHSN).MethodsPooled analysis of surveillance data that were prospectively collected between 2007 and 2016 in four hospitals of Ministry of National Guard Health Affairs. Definitions and methodology of HAIs and antimicrobial resistance were based on NHSN. Consecutive NHSN reports were used for comparisons.ResultsA total 1544 pathogens causing 1531 HAI events were included. Gram negative pathogens (GNP) were responsible for 63% of HAIs, with a significant increasing trend inKlebsiellaspp. and a decreasing trend inAcinetobacter. Methicillin-resistantStaphylococcus aureus(27.0%) was consistently less frequent than NHSN. Vancomycin-resistantEnterococci(VRE, 20.3%) were more than doubled during the study, closing the gap with NHSN. Carbapenem resistance was highest withAcinetobacter(68.3%) andPseudomonas(36.8%). Increasing trends of carbapenem resistance were highest inPseudomonasandEnterobacteriaceae, closing initial gaps with NHSN. With the exception ofKlebsiellaandEnterobacter, multidrug-resistant (MDR) GNPs were generally decreasing, mainly due to the decreasing resistance towards cephalosporins, fluoroquinolones, and aminoglycosides.ConclusionThe findings showed increasing trends of carbapenem resistance and VRE, which may reflect heavy use of carbapenems and vancomycin. These findings may highlight the need for effective antimicrobial stewardship programs, including monitoring and feedback on antimicrobial use and resistance.
Exploring institutional arrangements for local fish product labelling in Tuscany (Italy): a convention theory perspective
Authors: Prosperi Paolo , Vergamini Daniele , Bartolini Fabio 
Published: January 2020

AbstractIncreasing fish consumption along with rising competition in the global seafood market has brought fisheries and aquaculture producers to adopt several differentiation and marketing strategies. Labelling schemes were thus introduced to respond to a growing demand for traceable and sustainable products. However, the proliferation of quality labels brought to general confusion, calling for collective and public fish labels to ease decision-making. In our case study region (Tuscany, Italy), a number of policy-driven efforts were deployed for establishing regional labelling schemes for fisheries products with no observable impact on the market. Meanwhile, local companies have implemented a number of successful private and regional labels. The purpose of this research is to contribute to potential options for collective regional labelling schemes of fisheries and aquaculture products, through a case study analysis, building on agro-food value-chain and management approaches. Our empirical results highlight key issues and perspectives on labelling policies for local fisheries and aquaculture products.
Constellations of youth criminogenic factors associated with young adult violent criminal behavior
Authors: Segeren Menno , Fassaert Thijs , de Wit Matty , Popma Arne 
Published: January 2020

AbstractThis study identified constellations of childhood risk factors associated with violent criminal behavior in early adulthood. Police data were used to sample violent and nonviolent offenders from a population of young adult males with a history of juvenile probation. Risk factors were retrieved from their juvenile probation files. A single classification tree analysis organized these into a decision tree for violent criminal behavior with good predictive accuracy. Two constellations of risk factors were associated with a high risk of violent criminal behavior. The first consisted of juvenile delinquents who had been moderately involved with criminal peers, who had committed offenses under the influence of drugs, and who came from a dysfunctional family. The second was characterized by having been severely involved with criminal peers and having had criminal family members. Presenting with depressive symptoms in childhood was associated with a low risk of violent criminal behavior. These constellations bear clinical importance as they provide targets for personalized interventions.
Dilemmas about instructions for administering drugs and indications for their use: is there negative effect of pharmaceutical industry?
Authors: Zerem Enver 
Published: January 2020

AbstractInstructions for administering some drugs and indications for their use raise certain dilemmas and controversies questioning the appropriateness of the treatment in this way. In this article, some controversies regarding the prescribing of statins in patients whose blood cholesterol level is normal and the use of anticoagulants in the elderly patients without blood clots prior to the treatment are described. Also, it is discussed about some controversies regarding the use of the insulin analogues in the treatment of patients with diabetes mellitus.
Yaws in the Philippines: first reported cases since the 1970s
Authors: Dofitas Belen Lardizabal , Kalim Sherjan P. , Toledo Camille B. , Richardus Jan Hendrik 
Published: January 2020

Abstract
Background
Yaws is a chronic, highly contagious skin and bone infection affecting children living in impoverished, remote communities and caused by Treponema pallidum subspecies pertenue. The Philippines was thought to be free of yaws following the 1950s eradication campaign but it has been reported in the Liguasan Marsh area, Central Mindanao. This is the first documentation of yaws cases in the Philippines since the 1970s. We describe active and latent yaws recently detected in the Southern Philippines.

Case presentation
Cross-sectional surveys and screening of skin diseases were conducted in one randomly selected public elementary school per selected municipality in Liguasan Marsh, covering three municipalities per province. Yaws suspects underwent screening and confirmatory serologic tests for Treponema pallidum using Dual Path Platform Syphilis Screen and Confirm Assay (DPP) and Treponema pallidum Particle Agglutination (TPPA). Children with yaws skin lesions and reactive confirmatory tests for T. pallidum and non-treponemal antibodies were considered confirmed yaws cases. Four children aged 5–10 years old had confirmed secondary yaws in Tulunan Municipality, Cotabato Province and in Lambayong Municipality, Sultan Kudarat Province. All had secondary yaws lesions such as moist, cauliflower-like papillomas, thick yellow crusts on pink papules and nodules, whitish, papulosquamous papules and plaques, or hypopigmented patches with small papules on the periphery. Yaws papillomas and erosions were also found on the soles of the feet of one child. The index case had a skin punch biopsy of a partially treated papilloma on his axilla. Histopathological findings showed lichenoid psoriasiform dermatitis with plasma cells, consistent with yaws.

Conclusions
The clinical, serological, and histopathological confirmation of four yaws cases among children has made the Philippines the 14th country endemic for yaws. This report can help health personnel recognize hidden cases of yaws based on skin signs and serological tests. Yaws remained unrecognized and unreported in the Philippines and in countries previously endemic for yaws probably due to the unsustained integration of the yaws program in the general health services and complacency after the 1950s eradication campaign. Our findings have provided the necessary evidence and stimulus to develop a yaws control and eradication program as one of the country’s neglected tropical diseases.
Comparison of various pharmaceutical properties of clobetasol propionate cream formulations - considering stability of mixture with moisturizer-
Authors: Yamamoto Yoshihisa , Onuki Yoshinori , Fukami Toshiro , Koide Tatsuo 
Published: January 2020

Abstract
Background
The clobetasol propionate cream formulations (CLBCr) belong to the “strongest” group, and are used widely. In addition, those formulations are often used as a mixture with moisturizer. Recently, we evaluated pharmaceutical properties of the CLBCr using near infrared (NIR) spectroscopy, and characteristic NIR spectra depending on the formulation were observed. In the present study, we attempted to evaluate the more diverse pharmaceutical properties of CLBCr, including the stability of mixture of CLBCr and moisturizer.

Method
Pharmaceutical properties of CLBCr were evaluated using from rheological characteristics, microscopic observation, dye permeability observations, electrical conductivity method, thermogravimetry-differential thermal analysis (TG-DTA) and near infrared (NIR) spectroscopy. Stability of mixtures of CLBCr and moisturizer were evaluated using from dye method and NIR spectroscopy.

Results
The hardness of Dermovate® (DRM), Glydil® (GDL), and Myalone® (MYA) was greater than that of CLBCr. High concentrations of white beeswax were considered the reason for the hardness of DRM and GDL. On the other hand, the hardness of MYA may be due to the presence of macrogol 6000. After storage of the cream formulations discharged from the tube at room temperature, mass reduction and attenuation of the peak reflecting water of NIR spectroscopy occurred in a time-dependent manner, except for GDL and MYA. Only GDL was shown to be a w/o-type formulation by dye and electric conductivity measurements, which suggested that this was the reason for the lack of changes in the mass or NIR spectrum of samples after storage. In the NIR spectrum of MYA, the peak reflecting water slightly increased in a time-dependent manner, suggesting the water absorption of macrogol 6000. TG-DTA provided curves indicating the presence of water in each formulation, except for MYA, which was consistent with water quantification previously reported. Finally, when mixing the CLBCr with a moisturizer, in any CLBCr, the stability of the mixture with w/o-type moisturizer varies greatly depending on the each CLBCr.

Conclusion
Thus, even for cream formulations with the same active pharmaceutical ingredient, pharmaceutical properties and stability of mixture with moisturizer may different significantly.
Geospatial openness: from software to standards & data
Authors: Minghini Marco , Mobasheri Amin , Rautenbach Victoria , Brovelli Maria Antonia 
Published: January 2020

AbstractThis paper is the editorial of the Special Issue “Open Source Geospatial Software”, which features 10 published papers. The editorial introduces the concept of openness and, within the geospatial context, declines it into the three main components of software, data and standards. According to this classification, the papers published in the Special Issue are briefly summarized and a future research agenda in the open geospatial domain is finally outlined.
The use of cannabis for Hyperemesis Gravidarum (HG)
Authors: Koren Gideon , Cohen Rana 
Published: January 2020

Abstract
Background
Hyperemesis Gravidarum (HG) responds only partially to standard antiemetic medications. Cannabis has been known to possess antiemetic effects and there are several medicinal cannabinoids used as anti -emetics for cancer chemotherapy. Its favorable use for HG has been described in social media, but not in the medical literature.

Methods
We evaluated 4 women with HG counseled by the Motherisk Program, before and following the use of cannabis. Using the validated Pregnancy Unique Quantification of Emesis (PUQE) scoring system and employing the Student’s paired t test, we compared changes in symptoms following initiation of cannabis.

Results
There was a highly significant improvement in symptoms: PUQE score improved from 14.5+/− 1 to 7.5+/− 0.58(p = 0.0004). Cannabis use was associated with a significant increase in the PUQE Quality of Life scale, from 2+/− 0.82 to 7+/− 0.82 (p = 0.0012).

Conclusions
The results suggest that cannabis may be effective for HG, and should be studied in appropriately powered, controlled studies, fully considering potential fetal risks.
Reclassification of Pterulaceae Corner (Basidiomycota: Agaricales) introducing the ant-associated genus Myrmecopterula gen. nov., Phaeopterula Henn. and the corticioid Radulomycetaceae fam. nov.
Authors: Leal-Dutra Caio A. , Griffith Gareth W. , Neves Maria Alice , McLaughlin David J. , McLaughlin Esther G. , Clasen Lina A. , Dentinger Bryn T. M. 
Published: January 2020

AbstractPterulaceae was formally proposed to group six coralloid and dimitic genera: Actiniceps (=Dimorphocystis), Allantula, Deflexula, Parapterulicium, Pterula, and Pterulicium. Recent molecular studies have shown that some of the characters currently used in Pterulaceae do not distinguish the genera. Actiniceps and Parapterulicium have been removed, and a few other resupinate genera were added to the family. However, none of these studies intended to investigate the relationship between Pterulaceae genera. In this study, we generated 278 sequences from both newly collected and fungarium samples. Phylogenetic analyses supported with morphological data allowed a reclassification of Pterulaceae where we propose the introduction of Myrmecopterula gen. nov. and Radulomycetaceae fam. nov., the reintroduction of Phaeopterula, the synonymisation of Deflexula in Pterulicium, and 53 new combinations. Pterula is rendered polyphyletic requiring a reclassification; thus, it is split into Pterula, Myrmecopterula gen. nov., Pterulicium and Phaeopterula. Deflexula is recovered as paraphyletic alongside several Pterula species and Pterulicium, and is sunk into the latter genus. Phaeopterula is reintroduced to accommodate species with darker basidiomes. The neotropical Myrmecopterula gen. nov. forms a distinct clade adjacent to Pterula, and most members of this clade are associated with active or inactive attine ant nests. The resupinate genera Coronicium and Merulicium are recovered in a strongly supported clade close to Pterulicium. The other resupinate genera previously included in Pterulaceae, and which form basidiomes lacking cystidia and with monomitic hyphal structure (Radulomyces, Radulotubus and Aphanobasidium), are reclassified into Radulomycetaceae fam. nov. Allantula is still an enigmatic piece in this puzzle known only from the type specimen that requires molecular investigation. A key for the genera of Pterulaceae and Radulomycetaceae fam. nov. is also provided here.
The Detection of Serum IgMs to Thyroglobulin in Subacute Thyroiditis Suggests a Protective Role of IgMs in Thyroid Autoimmunity
Authors: Ricci Debora , Brancatella Alessandro , Marinò Michele , Rotondi Mario , Chiovato Luca , Vitti Paolo , Latrofa Francesco 
Published: January 2020

AbstractContextThe role of serum immunoglobulin (Ig)Ms in autoimmune thyroid diseases is uncertain.ObjectiveWe looked for IgMs to thyroglobulin (Tg) in patients with subacute thyroiditis (SAT), which is characterized by high serum Tg levels, the possible de novo appearance of IgGs to Tg (TgAb-IgGs), and no autoimmune sequelae.Main Outcome MeasuresTgAb-IgMs and TgAb-IgGs were detected by binding to Tg using the enzyme-linked immunosorbent assay (ELISA). The upper reference limit of TgAb-IgMs and TgAb-IgGs was established in 40 normal subjects. We looked for TgAb-IgMs in 16 patients with SAT, 11 with Hashimoto’s thyroiditis (HT), and 8 with Graves’ disease (GD) who were all positive for TgAb-IgGs. IgM binding to bovine serum albumin (BSA), keyhole limpet hemocyanin (KLH), and glucagon in ELISA was measured. Inhibition of TgAb-IgMs binding to coated Tg was evaluated by preincubating serum samples or IgG-depleted samples with soluble Tg.ResultsTgAb-IgMs were positive in 10/16 patients with SAT, 2/11 with HT, and 1/8 with GD. TgAb-IgMs were higher in SAT (0.95; 0.42–1.13) (median; 25th–75th percentiles) than in HT (0.47; 0.45–0.51) and GD patients (0.35; 0.33–0.40) (P &lt; .005 for both). IgM binding of SAT sera to BSA, KLH, and glucagon was significantly lower than Tg. Preincubation with soluble Tg reduced the binding of IgMs to coated Tg by 18.2% for serum samples and by 35.0% and 42.1% for 2 IgG-depleted samples. TgAb-IgM levels were inversely, although nonsignificantly, correlated with Tg concentrations.ConclusionsTg leak associated with thyroid injury induces the production of specific TgAb-IgMs, which, in turn, increases the clearance of Tg and might prevent the establishment of a persistent thyroid autoimmune response.
Perioperative Glucocorticoid Therapy for Patients with Adrenal Insufficiency: Dosing Based on Pharmacokinetic Data
Authors: Arafah Baha M 
Published: January 2020

Abstract

Background
Perioperative glucocorticoid therapy for patients with adrenal insufficiency (AI) is currently based on anecdotal reports, without supporting pharmacokinetic data.

Methods
We determined the half-life, clearance, and volume of distribution of 2 consecutive intravenously (IV)-administered doses of hydrocortisone (15 or 25 mg every 6 hours) to 22 dexamethasone-suppressed healthy individuals and used the data to develop a novel protocol to treat 68 patients with AI who required surgical procedures. Patients received 20 mg of hydrocortisone orally 2 to 4 hours before intubation and were started on 25 mg of IV hydrocortisone every 6 hours for 24 hours and 15 mg every 6 hours during the second day. Nadir cortisol concentrations were repeatedly measured during that period.

Results
In healthy individuals, cortisol half-life was longer when the higher hydrocortisone dose was administered (2.02 ± 0.15 vs 1.81 ± 0.11 hours; P &lt; 0.01), and in patients with AI, the half-life was longer than in healthy individuals given the same hydrocortisone dose. In both populations, the cortisol half-life increased further with the second hormone injection. Prolongation of cortisol half-life was due to decreased hydrocortisone clearance and an increase in its volume of distribution. Nadir cortisol levels determined throughout the 48 postoperative hours were within the range of values and often exceeded those observed perioperatively in patients without adrenal dysfunction.

Conclusions
Cortisol pharmacokinetics are altered in the postoperative period and indicate that lower doses of hydrocortisone can be safely administered to patients with AI undergoing major surgery. The findings of this investigation call into question the current practice of administering excessive glucocorticoid supplementation during stress.