bluuebunny/crossref_metadata_2025_split huggingface dataset:
Specification of deformation congruence models using combinatorial iterative DIA testing procedure
Authors: Nowel Krzysztof 
Published: November 2020

AbstractDeformation congruence models form the basis for conventional deformation analysis (CDA). In geometrical sense, these models connect an epochal object states—represented by its characteristic points—at stable/congruent points to disclose possible deformations. To this day, the deformation congruence models are usually specified using the global congruence test (GCT) procedure which, however, has a weakness in the case of multiple displacements. More precisely, the GCT procedure is based on consecutive point-by-point specification which may suffer from so-called displacement smearing. To overcome the above weakness, a revolutionary—in the context of GCT—concept (two methods) involving combinatorial possibilities was suggested in recent years. Admittedly, this concept avoids the problem of consecutive point-by-point specification. Nevertheless, it generates another weakness, namely the problem of the comparison of different-dimensional models. This paper makes a step forward in this new combinatorial field and discusses a more sophisticated combinatorial procedure, denoted as CIDIA. It was shown that, thanks to an appropriately used the possibilities of combinatorics and generalized likelihood ratio tests performed in the detection–identification–adaptation (DIA) iterative steps, the above weaknesses can be overcome. In the context of GCT, the suggested procedure has rather evolutionary—than revolutionary—character and the general concepts of both procedures have similar heuristic substantiation. To demonstrate the efficacy of CIDIA against GCT and the two existing combinatorial methods, various deformation scenarios were being randomized independently many times with the use of comprehensive computer simulations and then processed. Generally, the obtained results confirmed the statement that the suggested CIDIA procedure—unlike the existing combinatorial methods—can be substantially more resistant to displacement smearing than the GCT procedure, at no significant costs. The efficacy of CIDIA—unlike the ones of the two existing combinatorial methods—turned out always higher (on average by several percentages) than the one of GCT for all considered deformation scenarios. At the same time, the CIDIA procedure turned out substantially less time-consuming than the other combinatorial methods.
From Steklov to Neumann via homogenisation
Authors: Girouard Alexandre , Henrot Antoine , Lagacé Jean 
Published: November 2020

AbstractWe study a new link between the Steklov and Neumann eigenvalues of domains in Euclidean space. This is obtained through an homogenisation limit of the Steklov problem on a periodically perforated domain, converging to a family of eigenvalue problems with dynamical boundary conditions. For this problem, the spectral parameter appears both in the interior of the domain and on its boundary. This intermediary problem interpolates between Steklov and Neumann eigenvalues of the domain. As a corollary, we recover some isoperimetric type bounds for Neumann eigenvalues from known isoperimetric bounds for Steklov eigenvalues. The interpolation also leads to the construction of planar domains with first perimeter-normalized Stekov eigenvalue that is larger than any previously known example. The proofs are based on a modification of the energy method. It requires quantitative estimates for norms of harmonic functions. An intermediate step in the proof provides a homogenisation result for a transmission problem.
Homological mirror symmetry for generalized Greene–Plesser mirrors
Authors: Sheridan Nick , Smith Ivan 
Published: November 2020

AbstractWe prove Kontsevich’s homological mirror symmetry conjecture for certain mirror pairs arising from Batyrev–Borisov’s ‘dual reflexive Gorenstein cones’ construction. In particular we prove HMS for all Greene–Plesser mirror pairs (i.e., Calabi–Yau hypersurfaces in quotients of weighted projective spaces). We also prove it for certain mirror Calabi–Yau complete intersections arising from Borisov’s construction via dual nef partitions, and also for certain Calabi–Yau complete intersections which do not have a Calabi–Yau mirror, but instead are mirror to a Calabi–Yau subcategory of the derived category of a higher-dimensional Fano variety. The latter case encompasses Kuznetsov’s ‘K3 category of a cubic fourfold’, which is mirror to an honest K3 surface; and also the analogous category for a quotient of a cubic sevenfold by an order-3 symmetry, which is mirror to a rigid Calabi–Yau threefold.
Guiding Nipple-Areola Complex Reconstruction: Literature Review and Proposal of a New Decision-Making Algorithm
Authors: Paolini Guido , Firmani Guido , Briganti Francesca , Sorotos Michail , Santanelli di Pompeo Fabio 
Published: November 2020

Abstract
Background
Nipple-areola complex reconstruction (NAR) most commonly represents the finishing touch to breast reconstruction (BR). Nipple presence is particularly relevant to the patient’s psyche, beyond any shadow of doubt. Many reconstructive options have been described in time. Surgery is easy, but final result is often disappointing on the long run.

Methods
The goal of this manuscript is to analyze and classify knowledge concerning NAR techniques and the factors that influence success, and then to elaborate a practical evidence-based algorithm. Out of the 3136 available articles as of August 8th, 2020, we selected 172 manuscripts that met inclusion criteria, which we subdivided into 5 main topics of discussion, being the various NAR techniques; patient factors (including patient selection, timing and ideal position); dressings; potential complications and finally, outcomes/patient satisfaction.

Results
We found 92 articles describing NAR techniques, 41 addressing patient factors (out of which 17 discussed patient selection, 14 described ideal NAC location, 10 described appropriate timing), 10 comparing dressings, 7 studying NAR complications, and 22 addressing outcomes and patient satisfaction. We elaborated a comprehensive decision-making algorithm to help narrow down the choice among NAR techniques, and choose the correct strategy according to the various scenarios, and particularly the BR technique and skin envelope.

Conclusions
No single NAR technique provides definitive results, which is why we believe there is no “end-all be-all solution”. NAR must be approached as a case-by-case situation. Furthermore, despite NAR being such a widely discussed topic in scientific literature, we still found a lack of clinical trials to allow for more thorough recommendations to be elaborated.

Level of Evidence III
This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266
Skin changes in hairy cell leukemia
Authors: Robak Ewa , Jesionek-Kupnicka Dorota , Robak Tadeusz 
Published: November 2020

AbstractSkin lesions have been reported in about 10–12% of hairy cell leukemia (HCL) patients. Most are etiologically related to autoimmune or infectious processes, although secondary cutaneous neoplasms and drug-induced lesions are also reported. However, leukemia cutis with the direct infiltration of the skin by leukemic cells is extremely rare in HCL patients. This paper reviews the epidemiology, pathogenesis, clinical symptoms, diagnosis, and approach to treating skin lesions in HCL. A literature review of the MEDLINE database for articles in English concerning hairy cell leukemia, skin lesions, leukemia cutis, adverse events, infectious, cutaneous, drug reactions, neutrophilic dermatoses, secondary neoplasms, and vasculitis was conducted via PubMed. Publications from January 1980 to September 2020 were scrutinized. Additional relevant publications were obtained by reviewing the references from the chosen articles.
Effektivität der Kurzinterventionen in Traumaambulanzen
Authors: Keller Ferdinand , Rassenhofer Miriam , Nolting Björn , Koppmair Selma , Schepker Renate 
Published: November 2020

Zusammenfassung
Hintergrund
Baden-Württemberg hat ab 2014 fünf Modelltraumaambulanzen in Kooperation mit den Versorgungsbehörden prospektiv evaluieren lassen.

Ziel
Sowohl die Effektivität der Kurzinterventionen als auch die Zufriedenheit der Versorgungsämter mit der Kooperation sollten untersucht werden.

Methode
Innerhalb des Erhebungszeitraums von 2014 bis 2017 konnten insgesamt 122 Patienten eingeschlossen und zu 2 weiteren Messzeitpunkten (post: n = 90; Katamnese: n = 32) psychometrisch untersucht werden. Zur Katamnese fand auch eine qualitative Erhebung der Befindlichkeit der Teilnehmer statt.

Ergebnisse
Es zeigte sich eine gute Effektivität der im Durchschnitt etwa 5 Sitzungen umfassenden Frühinterventionen hinsichtlich der Reduktion posttraumatischer Symptomatik und einer Verbesserung des psychosozialen Funktionsniveaus der Patienten. Im Katamnesezeitraum traten bei allerdings geringer Ausschöpfung nur geringe Verschlechterungen ein. Als problematisch wurden Wartezeiten auf Anschlusstherapien, ausstehende Verhandlungen und unabgeschlossene Opferentschädigungsgesetz(OEG)-Verfahren benannt; eine berufliche Integration verhalf subjektiv zur Besserung. Die Versorgungsbehörden waren bis auf die nichteingetretene Beschleunigung der Bearbeitung mit der Kooperation sehr zufrieden. Auch wurden psychiatrische Gutachten weiterhin in Auftrag gegeben.

Schlussfolgerung
Der Zustand der Teilnehmer hatte sich nach der Kurzintervention zwar überwiegend gebessert, die Teilnehmer waren aber noch nicht gesundet. Eine enge Zusammenarbeit mit der Versorgungsbehörde ist unter Überwindung von Datenschutzproblemen zu empfehlen. Das neue Opferentschädigungsrecht wird helfen, erkannte Probleme der aktuellen Situation (z. B. Anerkennung als Gewalttat) zu verbessern.
Travelling wave solutions in a negative nonlinear diffusion–reaction model
Authors: Li Yifei , Heijster Peter van , Marangell Robert , Simpson Matthew J. 
Published: November 2020

AbstractWe use a geometric approach to prove the existence of smooth travelling wave solutions of a nonlinear diffusion–reaction equation with logistic kinetics and a convex nonlinear diffusivity function which changes sign twice in our domain of interest. We determine the minimum wave speed,$$c^*$$c∗, and investigate its relation to the spectral stability of a desingularised linear operator associated with the travelling wave solutions.
Perikarditis im Rahmen rheumatologischer Erkrankungen – Was der Rheumatologe wissen sollte
Authors: Krusche M. , Schneider U. , Ruffer N. 
Published: November 2020

ZusammenfassungAls Perikarditis wird eine Entzündung des Herzbeutels bezeichnet, die mit einem Perikarderguss oder einer entzündlichen Reaktion des Myokards (Perimyokarditis) einhergehen kann. Die Perikarditis kann im Rahmen von entzündlich rheumatischen Systemerkrankungen oder als eigenständige Erkrankung vorkommen. Rezidivierende Perikarditisepisoden ohne fassbare Ursache werden als idiopathische rekurrierende Perikarditis (IRP) bezeichnet, welche wesentliche Gemeinsamkeiten mit autoinflammatorischen Erkrankungen aufweist. Der Artikel gibt einen Überblick über die Häufigkeit des Auftretens einer Perikarditis bei rheumatologischen Erkrankungen. Weiterhin werden Klinik und Pathophysiologie der IRP diskutiert. Abschließend wird die Therapie der akuten und idiopathischen Perikarditis erläutert.
Acrylamide precipitation polymerization in a continuous flow reactor: an in situ FTIR study reveals kinetics
Authors: Fandrich Pascal , Wiehemeier Lars , Dirksen Maxim , Wrede Oliver , Kottke Tilman , Hellweg Thomas 
Published: November 2020

AbstractIn this work, we present a combination of a continuous flow reactor with in situ monitoring of the monomer conversion in a precipitation polymerization. The flow reactor is equipped with a preheating area for the synthesis of thermoresponsive microgels, based on N-isopropylacrylamide (NIPAM). The reaction progress is monitored with in situ FTIR spectroscopy. The monomer conversion at defined residence times is determined from absorbance spectra of the reaction solutions by linear combination with reference spectra of the stock solution and the purified microgel. The reconstruction of the spectra appears to be in good agreement with experimental data in the range of 1710 to 1530 cm− 1, in which prominent absorption bands are used as probes for the monomer and the polymer. With increasing residence time, we observed a decrease in intensity of the ν(C=C) vibration, originating from the monomer, while the ν(C=O) vibration is shifted to higher frequencies by polymerization. Differences between the determined inline conversion kinetics and offline growth kinetics, determined by photon correlation spectroscopy (PCS), are discussed in terms of diffusion and point to a crucial role of mixing in precipitation polymerizations.
Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis
Authors: Suwala Abigail K. , Stichel Damian , Schrimpf Daniel , Kloor Matthias , Wefers Annika K. , Reinhardt Annekathrin , Maas Sybren L. N. , Kratz Christian P. , Schweizer Leonille , Hasselblatt Martin , Snuderl Matija , Abedalthagafi Malak Sameer J. , Abdullaev Zied , Monoranu Camelia M. , Bergmann Markus , Pekrun Arnulf , Freyschlag Christian , Aronica Eleonora , Kramm Christof M. , Hinz Felix , Sievers Philipp , Korshunov Andrey , Kool Marcel , Pfister Stefan M. , Sturm Dominik , Jones David T. W. , Wick Wolfgang , Unterberg Andreas , Hartmann Christian , Dodgshun Andrew , Tabori Uri , Wesseling Pieter , Sahm Felix , von Deimling Andreas , Reuss David E. 
Published: November 2020

AbstractDiffuse IDH-mutant astrocytoma mostly occurs in adults and carries a favorable prognosis compared to IDH-wildtype malignant gliomas. Acquired mismatch repair deficiency is known to occur in recurrent IDH-mutant gliomas as resistance mechanism towards alkylating chemotherapy. In this multi-institutional study, we report a novel epigenetic group of 32 IDH-mutant gliomas with proven or suspected hereditary mismatch repair deficiency. None of the tumors exhibited a combined 1p/19q deletion. These primary mismatch repair-deficient IDH-mutant astrocytomas (PMMRDIA) were histologically high-grade and were mainly found in children, adolescents and young adults (median age 14 years). Mismatch repair deficiency syndromes (Lynch or Constitutional Mismatch Repair Deficiency Syndrom (CMMRD)) were clinically diagnosed and/or germline mutations in DNA mismatch repair genes (MLH1, MSH6, MSH2) were found in all cases, except one case with a family and personal history of colon cancer and another case with MSH6-deficiency available only as recurrent tumor. Loss of at least one of the mismatch repair proteins was detected via immunohistochemistry in all, but one case analyzed. Tumors displayed a hypermutant genotype and microsatellite instability was present in more than half of the sequenced cases. Integrated somatic mutational and chromosomal copy number analyses showed frequent inactivation of TP53, RB1 and activation of RTK/PI3K/AKT pathways. In contrast to the majority of IDH-mutant gliomas, more than 60% of the samples in our cohort presented with an unmethylated MGMT promoter. While the rate of immuno-histochemical ATRX loss was reduced, variants of unknown significance were more frequently detected possibly indicating a higher frequency of ATRX inactivation by protein malfunction. Compared to reference cohorts of other IDH-mutant gliomas, primary mismatch repair-deficient IDH-mutant astrocytomas have by far the worst clinical outcome with a median survival of only 15 months irrespective of histological or molecular features. The findings reveal a so far unknown entity of IDH-mutant astrocytoma with high prognostic relevance. Diagnosis can be established by aligning with the characteristic DNA methylation profile, by DNA-sequencing-based proof of mismatch repair deficiency or immunohistochemically demonstrating loss-of-mismatch repair proteins.
Ovarian teratoma-associated anti-NMDAR encephalitis: a single-institute series of six patients from China
Authors: Yu Minhua , Li Shanji , Cheng Jie , Zhou Liche , Jiang Zhou , Di Wen 
Published: November 2020

Abstract
Purpose
Ovarian teratoma-associated anti-N-methyl-d-aspartate receptor encephalitis is a rare disease with uncertain etiology and pathogenesis. The disorder is severe and rare with a great impact on young adults. This study aimed to improve the awareness of the disease from experience in our single center.

Methods
Between July 2012 and December 2019, six patients with ovarian teratoma-associated anti-N-methyl-d-aspartate receptor encephalitis were enrolled in Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University. All patients’ data like manifestations, laboratory and radiological data, treatment, and follow-up were reviewed.

Results
Typical psychotic symptoms, memory, and consciousness disorders accompanied by seizures were observed in all patients from this study. All six patients showed positive signals in serum and cerebrospinal fluid samples for N-methyl-d-aspartate receptor and received immunotherapy. Three patients underwent unilateral oophorocystectomy and the other three underwent unilateral oophorectomy through minimally invasive surgeries, including laparoscopic and single-port laparoscopic surgeries. The median follow-up time 24.5 months (range from 6 to 93 months). No death occurred. Two patients had recurrent psychotic symptoms while the left four patients had no mental symptoms or tumor recurrence during postoperative follow-up.

Conclusions
For patients with clinical manifestations of unexplained acute psychiatric symptoms accompanied by seizures, memory, and consciousness disorders, the possibility of anti-N-methyl-d-aspartate receptor encephalitis should be considered. To confirm the diagnosis, examinations of anti-N-methyl-d-aspartate receptor antibodies need to be completed as early as possible. Immunotherapy and tumor location should be given in time once the diagnosis is defined. We recommended removing the tumor as soon as possible without concerning whether the patient is in the acute phase or not. The surgical procedure should be decided based on pathology, age, fertility desire, and patients’ requirements and it should be ensured that tumors are completely removed during operation. Postoperative follow-up is particularly important.
Prenatal diagnosis, associated findings and postnatal outcome in fetuses with congenitally corrected transposition of the great arteries
Authors: Krummholz Andrea , Gottschalk I. , Geipel A. , Herberg U. , Berg C. , Gembruch U. , Hellmund A. 
Published: November 2020

Abstract
Purpose
To analyze anatomic features and associated malformations in 37 prenatally detected cases of congenitally corrected transposition of the great arteries (ccTGA) and to evaluate the prenatal course, neonatal outcome and mid-term follow-up.

Methods
Retrospective analysis of prenatal ultrasound of 37 patients with ccTGA in two tertiary centers between 1999 and 2019. All fetuses received fetal echocardiography and a detailed anomaly scan. Postnatal outcome and follow-up data were retrieved from pediatric reports.

Results
Isolated ccTGA without associated cardiac anomalies was found in 13.5% (5/37), in all other fetuses additional defects such as VSD (73.0%), pulmonary obstruction (35.1%), tricuspid valve anomalies (18.9%), aortic arch anomalies (13.5%), ventricular hypoplasia (5.4%) or atrioventricular block (5.4%) were present. The rate of extracardiac malformations or chromosomal aberrations was low. There were 91.9% (34/37) live births and postnatal survival rates reached 91.2% in a mean follow-up time of 4.98 years. The prenatal diagnosis of ccTGA was confirmed postnatally in all but one documented live birth and the prenatal counselling regarding the expected treatment after birth (uni- versus biventricular repair) was reassured in the majority of cases. The postnatal intervention rate was high, 64.7% (22/34) received surgery, the intervention-free survival was 36.7%, 35.0% and 25.0% at 1 month, 1 year and 10 years, respectively.

Conclusions
ccTGA is a rare heart defect often associated with additional heterogeneous cardiac anomalies that can be diagnosed prenatally. The presented study demonstrates a favorable outcome in most cases but the majority of patients require surgical treatment early in life.
Comparative use of aqueous humour 1H NMR metabolomics and potassium concentration for PMI estimation in an animal model
Authors: Locci Emanuela , Stocchero Matteo , Gottardo Rossella , De-Giorgio Fabio , Demontis Roberto , Nioi Matteo , Chighine Alberto , Tagliaro Franco , d’Aloja Ernesto 
Published: November 2020

AbstractEstimation of the post-mortem interval (PMI) remains a matter of concern in the forensic scenario. Traditional and novel approaches are not yet able to fully address this issue, which relies on complex biological phenomena triggered by death. For this purpose, eye compartments may be chosen for experimental studies because they are more resistant to post-mortem modifications. Vitreous humour, in particular, has been extensively investigated, with potassium concentration ([K+]) being the marker that is better correlated with PMI estimation. Recently, a 1H nuclear magnetic resonance (NMR) metabolomic approach based on aqueous humour (AH) from an animal model was proposed for PMI estimation, resulting in a robust and validated regression model. Here we studied the variation in [K+] in the same experimental setup. [K+] was determined through capillary ion analysis (CIA) and a regression analysis was performed. Moreover, it was investigated whether the PMI information related to potassium could improve the metabolome predictive power in estimating the PMI. Interestingly, we found that a part of the metabolomic profile is able to explain most of the information carried by potassium, suggesting that the rise in both potassium and metabolite concentrations relies on a similar biological mechanism. In the first 24-h PMI window, the AH metabolomic profile shows greater predictive power than [K+] behaviour, suggesting its potential use as an additional tool for estimating the time since death.
Operational sea passage scenario generation for virtual testing of ships using an optimization for simulation approach
Authors: Sandvik Endre , Nielsen Jørgen Bremnes , Asbjørnslett Bjørn Egil , Pedersen Eilif , Fagerholt Kjetil 
Published: November 2020

AbstractIn this paper, a model for implementation of sea passage operational scenarios in the context of simulation-based design of ships is presented. To facilitate the transition towards more energy-efficient shipping, the ability to evaluate and understand ship and ship system behaviour in operational conditions is central. By introducing an optimization model in virtual testing frameworks, operational scenarios can be generated that enhances scenario relevance and testing abilities. The optimization for simulation approach provides speed and course commands based on an optimization framework which factors in the operational considerations and sea state conditions in the area of operation. Impact on the understanding of ship system performance using simulation is assessed in a case study where a sea passage over the North Pacific is replicated for varying operational scenarios and seasons. It is found that the variation of operational scenario, affecting the sea state and speed relation, causes significant differences in required power and fuel consumption estimates. Sea passage control is found to be an important dimension in virtual testing approaches.