bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative morphological and transcriptomic analyses reveal chemosensory genes in the poultry red mite, Dermanyssus gallinae
Authors: Bhowmick Biswajit , Tang Yu , Lin Fang , Øines Øivind , Zhao Jianguo , Liao Chenghong , Ignell Rickard , Hansson Bill S. , Han Qian 
Published: October 2020

AbstractDetection of chemical cues via chemosensory receptor proteins are essential for most animals, and underlies critical behaviors, including location and discrimination of food resources, identification of sexual partners and avoidance of predators. The current knowledge of how chemical cues are detected is based primarily on data acquired from studies on insects, while our understanding of the molecular basis for chemoreception in acari, mites in particular, remains limited. The poultry red mite (PRM), Dermanyssus gallinae, is one of the most important blood-feeding ectoparasites of poultry. PRM are active at night which suck the birds' blood during periods of darkness and hide themselves in all kinds of gaps and cracks during the daytime. The diversity in habitat usage, as well as the demonstrated host finding and avoidance behaviors suggest that PRM relies on their sense of smell to orchestrate complex behavioral decisions. Comparative transcriptome analyses revealed the presence of candidate variant ionotropic receptors, odorant binding proteins, niemann-pick proteins type C2 and sensory neuron membrane proteins. Some of these proteins were highly and differentially expressed in the forelegs of PRM. Rhodopsin-like G protein-coupled receptors were also identified, while insect-specific odorant receptors and odorant co-receptors were not detected. Furthermore, using scanning electron microscopy, the tarsomeres of all leg pairs were shown to be equipped with sensilla chaetica with or without tip pores, while wall-pored olfactory sensilla chaetica were restricted to the distal-most tarsomeres of the forelegs. This study is the first to describe the presence of chemosensory genes in any Dermanyssidae family. Our findings make a significant step forward in understanding the chemosensory abilities of D. gallinae.
Evaluating the seasonality of growth in infants using a mobile phone application
Authors: Narumi Satoshi , Ohnuma Tetsu , Takehara Kenji , Morisaki Naho , Urayama Kevin Y. , Hattori Tomoyuki 
Published: October 2020

AbstractIt has been observed that growth velocity of toddlers and school children shows seasonal variation, while such seasonality is unknown in infants. The aim of this study was to examine whether growth velocity (length and weight) of infants differs by seasons. We assessed longitudinal measurement data obtained for 9,409 Japanese infants whose parents used the mobile phone application, “Papatto Ikuji”, during the period from January 2014 to October 2017. On average, each infant had 4.8 entries for length and 5.4 entries for weight. The mean daily change in sex- and age-adjusted z-scores between two time points was estimated as the growth velocity during that period: ΔLAZ/day and ΔWAZ/day for length and weight, respectively. We analyzed 20,007 ΔLAZ/day (mean, −0.0022) and 33,236 ΔWAZ/day (mean, 0.0005) measurements, and found that ΔLAZ/day showed seasonal differences with increases during summer. We conducted a multilevel linear regression analysis, in which effects of age, sex, nutrition and season of birth were adjusted, showing significant difference in ΔLAZ/day between winter and summer with a mean ΔLAZ/day difference of 0.0026 (95%CI 0.0015 to 0.0036; P < 0.001). This seasonal difference corresponded to 13% of the average linear growth velocity in 6-month-old infants. A modest effect of nutrition on linear growth was observed with a mean ΔLAZ/day difference of 0.0015 (95%CI 0.0006 to 0.0025; P < 0.001) between predominantly formula-fed infants and breastfed infants. In conclusion, we observed that linear growth, but not weight gain, of Japanese infants showed significant seasonality effects represented by increases in summer and decreases in winter.
Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy
Authors: Lobo Miguel J. , Reverte-Salisa Laia , Chao Ying-Chi , Koschinski Andreas , Gesellchen Frank , Subramaniam Gunasekaran , Jiang He , Pace Samuel , Larcom Natasha , Paolocci Ester , Pfeifer Alexander , Zanivan Sara , Zaccolo Manuela 
Published: October 2020

AbstractProgrammed degradation of mitochondria by mitophagy, an essential process to maintain mitochondrial homeostasis, is not completely understood. Here we uncover a regulatory process that controls mitophagy and involves the cAMP-degrading enzyme phosphodiesterase 2A2 (PDE2A2). We find that PDE2A2 is part of a mitochondrial signalosome at the mitochondrial inner membrane where it interacts with the mitochondrial contact site and organizing system (MICOS). As part of this compartmentalised signalling system PDE2A2 regulates PKA-mediated phosphorylation of the MICOS component MIC60, resulting in modulation of Parkin recruitment to the mitochondria and mitophagy. Inhibition of PDE2A2 is sufficient to regulate mitophagy in the absence of other triggers, highlighting the physiological relevance of PDE2A2 in this process. Pharmacological inhibition of PDE2 promotes a ‘fat-burning’ phenotype to retain thermogenic beige adipocytes, indicating that PDE2A2 may serve as a novel target with potential for developing therapies for metabolic disorders.
IM30 IDPs form a membrane-protective carpet upon super-complex disassembly
Authors: Junglas Benedikt , Orru Roberto , Axt Amelie , Siebenaller Carmen , Steinchen Wieland , Heidrich Jennifer , Hellmich Ute A. , Hellmann Nadja , Wolf Eva , Weber Stefan A. L. , Schneider Dirk 
Published: October 2020

AbstractMembers of the phage shock protein A (PspA) family, including the inner membrane-associated protein of 30 kDa (IM30), are suggested to stabilize stressed cellular membranes. Furthermore, IM30 is essential in thylakoid membrane-containing chloroplasts and cyanobacteria, where it is involved in membrane biogenesis and/or remodeling. While it is well known that PspA and IM30 bind to membranes, the mechanism of membrane stabilization is still enigmatic. Here we report that ring-shaped IM30 super-complexes disassemble on membranes, resulting in formation of a membrane-protecting protein carpet. Upon ring dissociation, the C-terminal domain of IM30 unfolds, and the protomers self-assemble on membranes. IM30 assemblies at membranes have been observed before in vivo and were associated with stress response in cyanobacteria and chloroplasts. These assemblies likely correspond to the here identified carpet structures. Our study defines the thus far enigmatic structural basis for the physiological function of IM30 and related proteins, including PspA, and highlights a hitherto unrecognized concept of membrane stabilization by intrinsically disordered proteins.
Reward uncertainty asymmetrically affects information transmission within the monkey fronto-parietal network
Authors: Taghizadeh Bahareh , Foley Nicholas C. , Karimimehr Saeed , Cohanpour Michael , Semework Mulugeta , Sheth Sameer A. , Lashgari Reza , Gottlieb Jacqueline 
Published: October 2020

AbstractA central hypothesis in research on executive function is that controlled information processing is costly and is allocated according to the behavioral benefits it brings. However, while computational theories predict that the benefits of new information depend on prior uncertainty, the cellular effects of uncertainty on the executive network are incompletely understood. Using simultaneous recordings in monkeys, we describe several mechanisms by which the fronto-parietal network reacts to uncertainty. We show that the variance of expected rewards, independently of the value of the rewards, was encoded in single neuron and population spiking activity and local field potential (LFP) oscillations, and, importantly, asymmetrically affected fronto-parietal information transmission (measured through the coherence between spikes and LFPs). Higher uncertainty selectively enhanced information transmission from the parietal to the frontal lobe and suppressed it in the opposite direction, consistent with Bayesian principles that prioritize sensory information according to a decision maker’s prior uncertainty.
Fracture dolomite as an archive of continental palaeo-environmental conditions
Authors: Baldermann Andre , Mittermayr Florian , Bernasconi Stefano M. , Dietzel Martin , Grengg Cyrill , Hippler Dorothee , Kluge Tobias , Leis Albrecht , Lin Ke , Wang Xianfeng , Zünterl Andrea , Boch Ronny 
Published: October 2020

AbstractThe origin of Quaternary dolomites in continental environments (e.g. karst and lakes) is barely constrained compared to marine dolomites in sedimentary records. Here we present a study of dolomite and aragonite formations infilling young fractures of the ‘Erzberg’ iron ore deposit, Austria, under continental-meteoric and low temperature conditions. Two dolomite generations formed shortly after the Last Glacial Maximum (~20 kyr BP): dolomite spheroids and matrix dolomite. Clumped isotope measurements and U/Th disequilibrium ages reveal formation temperatures of 0–3 °C (±6 °C) and 3–20 °C (±5 °C) for the both dolomite types, and depositional ages around 19.21 ± 0.10 kyr BP and 13.97 ± 0.08 kyr BP or younger, respectively. Meteoric solution and carbonate isotope compositions (δ18O, δ13C and 87Sr/86Sr) indicate the dolomites formed via aragonite and high-Mg calcite precursors from CO2-degassed, Mg-rich solutions. Our study introduces low temperature dolomite formations and their application as a sedimentary-chemical archive.
Diagnostik im Bereich des Gesundheitssports im Setting Sportverein
Authors: Tiemann Michael , Pauly Pia 
Published: October 2020

ZusammenfassungIm Bereich des organisierten Sports bzw. im Setting Sportverein wurden diagnostische Verfahren lange fast ausschließlich im Leistungs- und Hochleistungssport, insbesondere zur Leistungsdiagnostik und Trainingssteuerung, eingesetzt. Seit einigen Jahren finden entsprechende Maßnahmen aber auch im Gesundheits- und Fitnesssport vermehrt Anwendung. Durch ihren Einsatz sollen insbesondere vermeidbare individuelle Gesundheitsrisiken ausgeschlossen, die Belastungssteuerung optimiert und die Erreichung der anvisierten Gesundheits- und Verhaltenswirkungen überprüft werden. Der zunehmende Einsatz von Maßnahmen zur Diagnostik und Qualitätssicherung steht dabei auch in engem Zusammenhang mit den gestiegenen Qualitätsanforderungen an Gesundheitssportprogramme als förderungswürdige Leistung nach § 20 SGB V durch die gesetzlichen Krankenkassen.Im organisierten Sport hat der DTB eine Vorreiterrolle übernommen und mit Unterstützung seines wissenschaftlichen Beirats verschiedene qualitätssichernde und diagnostische Maßnahmen entwickelt. Hervorzuheben ist hier zum einen die Entwicklung und Einführung eines spezifischen Instruments zur Bewertung der Qualität (Evidenz) von Gesundheitssportprogrammen (QUAGES). Zur weitergehenden Diagnostik und Qualitätssicherung empfiehlt der DTB seinen Vereinen zum anderen den Einsatz weiterer diagnostischer Verfahren wie die Durchführung eines Risikochecks (PAR-Q) sowie von motorischen Tests wie den „2 km-Walking Test“ oder das „European Test Profile“.Perspektivisch werden die Entwicklung und Einführung eines ohne größere Hürden einsetzbaren Basis-Assessments sowie die Erstellung praxistauglicher Arbeits- und Umsetzungshilfen für Vereine und Übungsleiter*innen angeregt.
Rheumatologische medikamentöse Therapie bei Malignomanamnese
Authors: Schmalzing Marc 
Published: October 2020

ZusammenfassungRheumatologische Therapie bei Patienten mit Malignomanamnese ist mit komplexen Fragestellungen verbunden. Schwierigkeiten und Lösungsmöglichkeiten bei der Interpretation aussagekräftiger Studien werden dargestellt. Empfehlungen in Leitlinien zu diesem Thema werden diskutiert. Nationale Register und Versicherungsdatenbanken wurden mit der Frage nach Tumorrezidivrisiko unter Basistherapeutika untersucht ; diese Analysen beziehen sich aber v. a. auf TNF-Inhibitoren und Rituximab. Zu den gängigen Substanzen der Basistherapie werden Daten zur Tumorinzidenz und wenn vorhanden zum Tumorrezidivrisiko zusammengefasst. Abschließend wird der Versuch unternommen Vorschläge zur rheumatolgischen Therapie bei Malignomanamnese zu formulieren.
Predicitve Value of FDG Uptake in the Remaining Adrenal Gland
Following Adrenalectomy for Adrenocortical Cancer
Authors: Loewe Ruben , Rogowski-Lehmann Natalie , Pfluger Thomas , Reincke Martin , Hahner Stefanie , Bluemel Christina , Fassnacht Martin , Beuschlein Felix 
Published: October 2020

AbstractFollowing initial surgery, patients with adrenocortical carcinoma (ACC) are
commonly treated with the adrenolytic substance mitotane in an adjuvant or
therapeutic setting. Treatment responses, however, are variable. The objective
of the study was to investigate a possible correlation between FDG-PET activity
of the remaining adrenal gland and therapeutic response of mitotane treatment.
This is a retrospective study enrolling patients from two German centers with
operated ACC and minimal information on PET-CT scanning. Eighty-two ACC patients
after adrenalectomy were included (66 treated with mitotane and 16 without
medical therapy). FDG uptake of the contralateral adrenal gland, liver and
mediastinum was analyzed from a total of 291 PET/CT scans (median 4
scans per patient) and correlated with clinical annotations including overall
and recurrence free survival. The majority of patients (81%) displayed a
temporary increase in adrenal FDG uptake within the first 18 months following
surgery, which was not associated with a morphological correlate for potential
malignancy. This increase was mainly present in patients treated with mitotane
(51/61, 84%) but less frequent in the control group
(4/7, 57%). No direct correlation with mitotane plasma levels
were evident. Patients following R0 resection with high adrenal uptake showed a
tendency towards better clinical outcome without reaching a significance value
(HR 1.41; CI 0.42–4.75; p=0.059). FDG update of the
contralateral adrenal gland may not be misinterpreted as sign of malignancy but
might be rather associated with a trend towards better clinical outcome.
Next Generation Sequencing in Pediatric Epilepsy Using Customized Panels: Size Matters
Authors: Willimsky Eva-Katharina , Munzig Anna , Mayer Karin , Biskup Saskia , Abicht Angela , Hoertnagel Konstanze , Voss Hubertus von , Klein Hanns-Georg , Rost Imma , Larsen Line H.G. , Dahl Hanns Atli , Hoelz Hannes , Stuelpnagel Celina von , Borggraefe Ingo 
Published: October 2020

AbstractIntroduction Next generation sequencing (NGS) with customized gene panels is a helpful tool to identify monogenic epilepsy syndromes. The number of genes tested within a customized panel may vary greatly. The aim of the present study was to compare the diagnostic yield of small (<25 kb) and large (>25 kb) customized epilepsy panels.Methods This retrospective cohort study investigated data of 190 patients of 18 years or younger, with the diagnosis of an epilepsy of unknown etiology who underwent NGS using customized gene panels. Small (<25 kb) and large (>25 kb) panels were compared regarding the distribution of benign/likely benign and pathogenic/likely pathogenic variants and variants of unclear significance. In addition, differences of the diagnostic yield with respect to epilepsy severity, i.e., developmental and epileptic encephalopathy [DEE] vs. non-DEE, were analyzed.Results The diagnostic yield defined as pathogenic or likely pathogenic variants in large panels was significantly increased (29% [n = 14/48] vs. 13% [n = 18/142], p = 0.0198) compared with smaller panels. In non-DEE patients the increase of the diagnostic yield in large panels was significant(35% n = 6/17 vs. 13% n = 12/94, p = 0.0378), which was not true for DEE patients.Discussion This study indicates that large panels are superior for pediatric patients with epilepsy forms without encephalopathy (non-DEE). For patients suffering from DEE small panels of a maximum of 10 genes seem to be sufficient. The proportion of unclear findings increases with rising panel sizes.Conclusion Customized epilepsy panels of >25 kb compared with smaller panels show a significant higher diagnostic yield in patients with epilepsy especially in non-DEE patients.
Assessment of Anxiety and Stress among Dental Students to Return to Training in Dental College in COVID-19 Era
Authors: Kharma Mohamed Yaser , Koussa Baydaa , Aldwaik Ahmed , Yaseen Jumana , Alamari Sulaiman , Alras Hala , Almech Mohamad 
Published: October 2020

AbstractObjectives The aim of this study is to evaluate the sources of anxiety and stress among dental students when returning back to training in dental colleges in the era of COVID-19, with the evaluation of a secure condition for training and practicing without the risk of contamination.Materials and Methods A questionnaire was edited in English and distributed to the dental students through the official site of Al-Farabi Private College/Jeddah/KSA. The questionnaire was assessed with different parameters: general information of respondents, anxiety and stress during dental training, importance criteria to be applied by dental college, and exploring the uses and benefits of e-learning.Results There were 315 respondents who participated in the study. About 85% participants feel anxiety and stress to return to the dental college. Theses-fearing expressed as high level for 63% compared with 2% before COVID-19. Almost 75% had supported the procedures to be implemented to ensure the safety of the students. About 43% of respondents agreed to continue e-learning in theoretical part only, 1% for clinical part only, and 47% in both. Finally, 67% of respondents preferred the use of alternative methods of learning (Phantom Laboratory) or any simulated teaching aids.Conclusions A revision of infection control management, improving the working environment, and learning how to deal with patients in purpose to protect everyone are mandatory to alleviate student anxiety to return to training in dental colleges.
Does Periodontal Treatment Help in Arterial Hypertension Control? A Systematic Review of Literature
Authors: Lanau Neus , Mareque-Bueno Javier , Zabalza Michel 
Published: October 2020

AbstractArterial hypertension and periodontal diseases are two of the pathologies with more prevalence worldwide. In the last few years, several scientific evidences have demonstrated the relationship between both diseases. Besides the etiopathogenic and causal relationship, some recent publications have pointed out that the therapeutic approach of periodontitis could have positive effects on the control of arterial hypertension.The aim of this systematic review is to determine whether there is a decrease in or better control of blood pressure after performing nonsurgical periodontal treatment in patients with periodontitis.A thorough search in PubMed, Scopus, and ISI Web of Science databases with the keywords “‘periodontal disease’ OR ‘periodontitis’ OR ‘periodontal’ AND ‘blood pressure’ OR ‘hypertension’ OR ‘arterial hypertension’” was conducted. The quality of the reported information was assessed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement for systematic reviews.Eight articles were considered for this systematic review. Five of the studies showed statistically significant reduction in systolic blood pressure (SBP) values.Despite the limitations of the review, nonsurgical treatment of periodontal disease seems to reduce SBP values. Further research with larger and longer-term clinical trials are needed to demonstrate this potential positive effect.
Not all grammatical features are robustly transmitted during the emergence of creoles
Authors: Sessarego Sandro 
Published: October 2020

AbstractThis paper addresses the long-standing debate on the nature and complexity of creole languages. Contrary to what has been claimed in the literature, it is argued that grammars are neither robustly transmitted during the emergence of creoles nor that creole languages represent the simplest grammars in the world. On the contrary, after laying down a theoretical framework that spells out the existence of at least three distinct second-language acquisition (SLA) processes shaping creoles, it is shown how different aspects of the ancestor grammars (and their potential complexities) may or may not be transmitted to the emerging creoles and why.
Improved conflict resolution in romantic couples in mediation compared to negotiation
Authors: Bogacz François , Pun Thierry , Klimecki Olga M. 
Published: October 2020

AbstractDespite the frequency and adverse effects of conflict, randomized controlled studies on interventions that could promote conflict resolution (e.g., among romantic couples) are scarce. One understudied intervention technique is mediation, which is a negotiation facilitated by a neutral third party. To test the impact of a mediator on couple conflict, we conducted a randomized controlled study involving 38 romantic couples who discussed a topic of recurrent disagreement either in the presence of a mediator or by means of a direct negotiation. The results show that romantic couples in the mediation condition, compared with those in direct negotiation, had a probability of reaching an agreement 1.39 times higher and reported higher satisfaction regarding the content and process of their discussions. In addition, the synchronicity of the couple’s skin conductance, a measure of arousal, correlated with the couple’s closeness and with the quality of their relationship. Our findings suggest that interventions based on mediation can have a beneficial impact on conflict resolution.
New distance measures of hesitant fuzzy linguistic term sets
Authors: Wu Shuangsheng , Lin Jie , Zhang Zhenyu 
Published: October 2020

Abstract
Hesitant fuzzy linguistic term sets (HFLTSs) is an important decision-making tool for qualitative evaluation, and the distance measures between HFLTSs have been widely concerned. The purpose of this paper is to overcome the defects of the existing distance measures between HFLTSs and propose some improved and more reasonable distance measures of HFLTSs. Firstly, we find that the existing HFLTSs distance measures do not satisfy basic properties such as triangle inequality through analysis. Additionally, considering that the existing distance measures do not think about the influence of the different number of linguistic terms on the calculated results, some distance measures considering both the decision-makers’ hesitance degree and linguistic term values are further proposed. The developed distance measures not only satisfy the basic properties but also avoid the loss of decision information. Finally, the developed distance measures are applied to the field of judicial execution and compared with the calculation results of the existing distance measures. The results show that the developed distance measures are more consistent with the actual decision-making process, which is helpful in improving the quality of decision-making.
Solitons and periodic waves for a generalized (3+1)-dimensional Kadomtsev–Petviashvili equation in fluid dynamics and plasma physics
Authors: Wang Dong , Gao Yi-Tian , Ding Cui-Cui , Zhang Cai-Yin 
Published: October 2020

Abstract
Under investigation in this paper is a generalized (3+1)-dimensional Kadomtsev–Petviashvili equation in fluid dynamics and plasma physics. Soliton and one-periodic-wave solutions are obtained via the Hirota bilinear method and Hirota–Riemann method. Magnitude and velocity of the one soliton are derived. Graphs are presented to discuss the solitons and one-periodic waves: the coefficients in the equation can determine the velocity components of the one soliton, but cannot alter the soliton magnitude; the interaction between the two solitons is elastic; the coefficients in the equation can influence the periods and velocities of the periodic waves. Relation between the one-soliton solution and one-periodic wave solution is investigated.