bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cefaclor as a first-line treatment for acute uncomplicated cystitis: a retrospective single-center study
Authors: Koguchi Dai , Murakami Yasukiyo , Ikeda Masaomi , Dobashi Masato , Ishii Junichiro 
Published: April 2020

Abstract
Background
Wide-spectrum antibiotics have been favored to treat acute uncomplicated cystitis (AUC) for a long time, leading to the emergence of multi-drug resistant bacteria. We hypothesize that narrow-spectrum antibiotics might mitigate the issue and aim to investigate the clinical efficacy of cefaclor in patients with AUC.

Methods
We retrospectively reviewed the clinical data of female outpatients with AUC treated with cefaclor and evaluated the safety and clinical efficacy. Clinical cure was defined as the elimination of clinical symptom under 4 white blood cells (WBCs) per high power field on microscopy.

Results
Overall, 223 women with AUC were enrolled. Escherichia coli was the dominant pathogen (n = 160; 68.6%), followed by Klebsiella species and E. coli-extended spectrum β-lactamase (ESBL) (n = 19; 8.1% and n = 18; 7.7%). Overall success rate was 94.0% (n = 219) and susceptibility rate of cefazolin was 84.1%, which was close to that of levofloxacin (82.9%). Ampicillin showed the lowest rate of 63.7% with a significantly greater resistance rate of 35.3% among all antibiotics (P < 0.001). In the subgroup analysis, the success rate in patients with resistance to levofloxacin or cefazolin was 100% (n = 24) or 93.3% (n = 14). The rate in patients with resistance to both antibiotics was 60.0% (n = 9), and the pathogens in the other 40.0% (n = 6) of patients with treatment failure were E. coli-ESBL.

Conclusion
Cefaclor showed excellent efficacy in AUC patients, even in those with in vitro resistance to cefazolin or levofloxacin. Cefaclor may be considered as a first-line option in patients with AUC and a second-line option for those with levofloxacin treatment failure.
Evaluation of a novel ovarian cancer-specific fluorescent antibody probe for targeted near-infrared fluorescence imaging
Authors: Chen Junchen , Zhang Chen , Guo Yanxiu , Chang Xiaohong , Ma Ruiqiong , Ye Xue , Cheng Hongyan , Li Yi , Cui Heng 
Published: April 2020

Abstract
Background
To meet clinical needs, fluorescence-guided surgery has emerged as a new technique that guides surgeons in the resection of cancerous tissue by highlighting tumour lesions during surgery. We aimed to evaluate the novel ovarian cancer-specific antibody fluorescent probe COC183B2-800 (COC183B2 conjugated with IRDye800CW) in tumour-specific imaging to determine if it can help surgeons remove malignant lesions under fluorescence guidance.

Methods
The expression of OC183B2 antigen in epithelial ovarian cancer (EOC) tissues and cell lines was determined using immunohistochemistry (IHC). Western blotting was used to verify the expression of OC183B2 in SKOV3-Luc tumours. Antibodies against OC183B2 and mouse immunoglobulin G1 (IgG1) were conjugated with IRDye800CW to develop the antibody fluorescent probes COC183B2-800 and IgG-800 (immunoglobulin G1 conjugated with IRDye800CW). A subcutaneous mouse tumour model of SKOV3-Luc cells was constructed. Bioluminescent imaging (BLI) was conducted to detect the tumour location. Near-infrared fluorescence (NIRF) imaging was performed after the mice were injected with imaging agents. The mice were sacrificed 96 h postinjection, and the biodistribution assays were performed using NIRF imaging.

Results
In 69 EOC patients, the total positive rate of OC183B2 in EOC tissues was 89.9% (62/69). Expression of the OC183B2 antigen was positive in SKOV3-Luc, 3AO, ES2 and A2780 cells. The OC183B2 antigen could be detected in SKOV3-Luc tumours. NIRF imaging of the COC183B2-800 probe at different doses showed a high fluorescent signal at the tumour location that was in line with the site detected by bioluminescent imaging. The tumour background ratio (TBR) was significantly higher in the COC183B2-800 group than in the IgG-800, IRDye800CW and PBS groups. The fluorescent probe COC183B2-800 is metabolized mainly through the liver and does not accumulate in other organs.

Conclusions
COC183B2-800 shows effective tumour-specific targeting of EOC and is a promising diagnostic and therapeutic tool for fluorescence-guided surgery.
Long-term survival and costs following extracorporeal membrane oxygenation in critically ill children—a population-based cohort study
Authors: Fernando Shannon M. , Qureshi Danial , Tanuseputro Peter , Dhanani Sonny , Guerguerian Anne-Marie , Shemie Sam D. , Talarico Robert , Fan Eddy , Munshi Laveena , Rochwerg Bram , Scales Damon C. , Brodie Daniel , Thavorn Kednapa , Kyeremanteng Kwadwo 
Published: April 2020

AbstractBackgroundExtracorporeal membrane oxygenation (ECMO) is used to provide temporary cardiorespiratory support to critically ill children. While short-term outcomes and costs have been evaluated in this population, less is known regarding long-term survival and costs.MethodsPopulation-based cohort study from Ontario, Canada (October 1, 2009 to March 31, 2017), of pediatric patients (< 18 years of age) receiving ECMO, identified through the use of an ECMO procedural code. Outcomes were identified through linkage to provincial health databases. Primary outcome was survival, measured to hospital discharge, as well as at 1 year, 2 years, and 5 years following ECMO initiation. We evaluated total patient costs in the first year following ECMO.ResultsWe analyzed 342 pediatric patients. Mean age at ECMO initiation was 2.9 years (standard deviation [SD] = 5.0). Median time from hospital admission to ECMO initiation was 5 days (interquartile range [IQR] = 1–13 days). Overall survival to hospital discharge was 56.4%. Survival at 1 year, 2 years, and 5 years was 51.5%, 50.0%, and 42.1%, respectively. Among survivors, 99.5% were discharged home. Median total costs among all patients in the year following hospital admission were $147,957 (IQR $70,571–$300,295). Of these costs, the large proportion were attributable to the inpatient cost from the index admission (median $119,197, IQR $57,839–$250,675).ConclusionsChildren requiring ECMO continue to have a significant in-hospital mortality, but reassuringly, there is little decrease in long-term survival at 1 year. Median costs among all patients were substantial, but largely reflect inpatient hospital costs, rather than post-discharge outpatient costs. This information provides value to providers and health systems, allowing for prognostication of short- and long-term outcomes, as well as long-term healthcare-related expenses for pediatric ECMO survivors.
Problems and Prospects of Organizing a Counselor's Practice for Students of the Faculty of Preschool Pedagogy and Psychology of MPSU
Authors: Semenova Tatiana 
Published: April 2020

The author describes the experience of organizing and conducting a summer teaching counselor practice at the faculty of preschool pedagogy and psychology of the Moscow State Pedagogical University (MPSU) as a social and pedagogical innovation, analyzes the problems and highlights the prospects for the implementation of the module «basics of counselor activity».
The purpose of the study: the study of opinions of students of Faculty of preschool pedagogy and psychology Moscow State Pedagogical University (MSPU) relative to years of teaching leader practices for consolidation and analysis of their experience; identification of problems and definition of prospects of the organization and conduct of this practice, the dissemination of pedagogical experience.
Research problem:
1.	study of the opinion of students of the faculty of preschool pedagogy and psychology of MPSU regarding the organization and conduct of summer pedagogical leader practice;
2.	identification of the attitude of students of the faculty of preschool pedagogy and psychology to the study of the module "Basics of leadership activity";
3.	justification of the need to study the module "Basics of leadership activities" and include leadership practice in the curriculum of students' training, identifying problems and determining the prospects for its organization and implementation.
Resonator fiber-optic gyro with intensity error suppression using a bias-sampling compensation technique
Authors: Shang Kejun , Lei Ming , Fang Yuan , Yu Huaiyong , Zhang Lizhe 
Published: April 2020

Resonator fiber-optic gyros (RFOGs) are one of the most promising
candidates for next-generation inertial rotation sensors. The
frequency servo loop is used to lock the laser frequency to the
resonance frequency of fiber ring resonator via adjusting the laser
diode current, which increases accompanying intensity variation and
induces RFOG drift. RFOG output compensation using a bias-sampling
technique is proposed to suppress intensity error. The linear
relationship between the RFOG output and bias is verified by theory
and experimental results, and the bias-sampling compensation technique
by monitoring the bias signal is analyzed in detail. With the
compensation technique, intensity error is significantly suppressed,
and the RFOG bias stability is effectively improved from 127.2 to
7.4 deg/h, which demonstrates tactical-grade performance.
Application of resilience assessment grid in production of aircraft components
Authors: Sekeľová Frederika , Lališ Andrej 
Published: April 2020

The paper evaluates an application of the resilience measuring tool Resilience Assessment Grid (RAG) in the aircraft components production. For the purpose of the evaluation a specific RAG model for a change process is created. The paper contains a description of change process and the approval process of the engineering change proposal. Paper describes BPMN and FRAM models created to support model RAG and which both clarify relations among the functions inside the management of change process. The paper presents a possible approach for the Resilience Assessment Grid model creation. The outcome is a creation of a change process profile in a company producing aircraft components in which change process and approval of the engineering proposed change is managed, and a recording of a current state of four process potentials that can be used by the company management to develop wider safety awareness among employees.
Effect of State Immunization Information System Centralized Reminder and Recall on HPV Vaccination Rates
Authors: Szilagyi Peter , Albertin Christina , Gurfinkel Dennis , Beaty Brenda , Zhou Xinkai , Vangala Sitaram , Rice John , Campbell Jonathan D. , Whittington Melanie D. , Valderrama Rebecca , Breck Abigail , Roth Heather , Meldrum Megan , Tseng Chi-Hong , Rand Cynthia , Humiston Sharon G. , Schaffer Stanley , Kempe Allison 
Published: April 2020

BACKGROUND:
Although autodialer centralized reminder and recall (C-R/R) from state immunization information systems (IISs) has been shown to raise childhood vaccination rates, its impact on human papillomavirus (HPV) vaccination rates is unclear.

METHODS:
In a 4-arm pragmatic randomized controlled trial across 2 states, we randomly selected practices representative of the specialty (pediatrics, family medicine, and health center) where children received care. Within each practice, patients 11 to 17.9 years old who had not completed their HPV vaccine series (NY: N = 30 616 in 123 practices; CO: N = 31 502 in 80 practices) were randomly assigned to receive 0, 1, 2, or 3 IIS C-R/R autodialer messages per vaccine dose. We assessed HPV vaccine receipt via the IIS, calculated intervention costs, and compared HPV vaccine series initiation and completion rates across study arms.

RESULTS:
In New York, HPV vaccine initiation rates ranged from 37.0% to 37.4%, and completion rates were between 29.1% and 30.1%, with no significant differences across study arms. In Colorado, HPV vaccine initiation rates ranged from 31.2% to 33.5% and were slightly higher for 1 reminder compared with none, but vaccine completion rates, ranging from 27.0% to 27.8%, were similar. On adjusted analyses in Colorado, vaccine initiation rates were slightly higher for 1 and 3 C-R/R messages (adjusted risk ratios 1.07 and 1.04, respectively); completion rates were slightly higher for 1 and 3 C-R/R messages (adjusted risk ratios 1.02 and 1.03, respectively).

CONCLUSIONS:
IIS-based C-R/R for HPV vaccination did not improve HPV vaccination rates in New York and increased vaccination rates slightly in Colorado.
¿Es la política internacional, una intención de integración o desintegración? Y ¿la ciudadanía? Análisis del caso de la “transición” del socialismo al “capitalismo globalizado”
Authors: Vélez Gallego Gabriela 
Published: April 2020

Este artículo de refl exión es un llamado a pensar por qué los países socialistas o comunistas ingresaron a las ideologías capitalistas; para ello, parte de un análisis que resalta el momento histórico en el que se da el desarrollo tecnológico, el cual adquiere un auge al considerar que quien tiene la información tiene el poder y analiza el hecho de que si hay globalización, entonces se debe promover el ciudadano global. Ante este reto de la educación de formar para la ciudadanía global, se pregunta: ¿a qué tipo de ciudadano y a qué tipo de ciudadanía apunta la globalización? Por último, se analiza el deber ser de los organismos internacionales en cuanto a su compromiso de garantizar la estabilidad política global, el cual no ha sido así, por las actuaciones que ha mostrado en sus intervenciones y da a conocer las realidades del socialismoeste y su ingreso al capitalismo-occidente.
Una reflexión sobre las raíces teórico-jurídicas del derecho de la competencia en Colombia
Authors: Hernandez Collazos Freddy , Latorre Iglesias Edimer 
Published: April 2020

En el marco de la reflexividad, este artículo propone una analísis de las bases teoricas que le dan le dan un sustento deontológico al derecho de la competencia en el ordenamiento jurídico colombiano; reconociendo el impacto de la globalización como un fenómeno cultural, inmerso en la economía de los diferentes países, el cual ha facilitado el intercambio continuo de productos, la competencia en los mercados, pero bajo ciertos requerimientos y restricciones que promuevan la calidad sin afectar la equidad en las relaciones de producción y permitan la intervención de organismos nacionales e internacionales, veedores de la eficacia, transparencia de las negociaciones y garantes de la proteccion de los derechos de los consumidores y sociedad en general. Para lograr tal objetivo, se plantearon metodologías hermenéuticas, basándose en el análisis del Derecho Económico y por último, se señalaron los desafíos del derecho de la competencia para América Latina.

AbstractThis article searching to analyze the theories about deontical argument tothe competitive law, in the Colombia legal system, but it's must to think over the impact globalization cultural phenomenon, inside of the economic countries. Also, it's situation has allowed the echanged products' the competitive in the Market, buyt according to laws and others requirements and certify the quality, without damage the production relationals and it's easy the participation international and national institution, the care and protection the users andsociety right. Additionally, in this investigation for to obtain this objective to methodology interpretation it based in the Economy Law and the competition law's for Latin America.
Informing Computer Vision with Optical Illusions
Authors: Nematzadeh Nasim , Powers David Martin Ward , Lewis Trent 
Published: April 2020

Abstract
Illusions are fascinating and immediately catch people's attention and interest, but they are also valuable in terms of giving us insights into human cognition and perception. A good theory of human perception should be able to explain the illusion, and a correct theory will actually give quantifiable results. We investigate here the efficiency of a computational filtering model utilised for modelling the lateral inhibition of retinal ganglion cells and their responses to a range of Geometric Illusions using isotropic Differences of Gaussian filters. This study explores the way in which illusions have been explained and shows how a simple standard model of vision based on classical receptive fields can predict the existence of these illusions as well as the degree of effect across multiple scales. A fundamental contribution of this work is to highlight the fact that it may be too early and hastly to reject isotropic filters altogether in favour of orientation selective ones for explaining mid/high level visual phenomena. Therefore the intention here is to link bottom-up processes to higher level perception and cognition consistent with Marr's theory of vision and edge map representation.
Chemical synthesis of SmAlO3 by stearic acid route: structure, morphology and microwave dielectric properties
Authors: Li J.M. , Zhang Chuimin , Liu Hui , Qiu Tai , Fan Chuangang 
Published: April 2020

Abstract
A rapid and facile approach was developed for the synthesis of ultrafine SmAlO3 powders through spontaneously combusting stearic acid precursors. The obtained products were characterized by typical techniques including X-ray diffraction (XRD), Fourier Transform Infrared (FT-IR), thermogravimetric and differential thermal analysis (TG-DTA), scanning electron microscopy (SEM) and electron microscopy transmission (TEM) to analyze the phase composition and microstructure. The dielectric characteristics of SmAlO3 microwave ceramics using the as-obtained products as original materials were also studied. Comparing with conventional solid-state reaction method, the synthesis temperature was dramatically reduced to 750 °C. Large size sheet structure was composed of a number of micro/nano-scale crystallites that were almost irregular in shape due to the mutual growth and overlapped shape of adjacent grains. The SmAlO3 ceramics with high density and uniform microstructure were obtained after sintering at 1500 °C for 4 h due to good sintering activity of the as-synthesized powders. In addition, desired dielectric properties at microwave frequencies (dielectric constant εr = 20.22, quality factor Q·f = 74110 GHz, and temperature coefficient of resonant frequency TCf = -74.6 ppm/°C) were achieved.
Potential risk factors for the reactivation of the replication of hepatitis B viruses after transcatheter arterial chemoembolization of hepatocellular carcinoma: a retrospective analysis
Authors: Wang Xiaoguang , Yang Xiaodan , Yu Haitao , Song Zhengwei , Chen Fei , Fei Jianguo 
Published: April 2020

Abstract
Objective: To investigate the clinical features of hepatitis B virus(HBV) reactivation after transcatheter arteriaI chemoembolization (TACE) treatment in patients with hepatocellular carcinoma (HCC), and analyze the relationship between hepatitis B virus reactivation and clinicopathological factors and prognosis. Methods: Clinical data of 108 patients with HCC treated by TACE from January 2006 to January 2014 were retrospectively studied. The relationship between the clinical data and HBV reactivation were analyzed and the differences in survival rates between the reactivation group and the non-reactivation group were also compared. Results: 42 (38.9%) patients developed HBV reactivation. The reactivation rate in patients with HBV DNA ≥ 104 was 65.8% (25/38), and was much higher than that of the patients with HBV DNA < 104 (24.3%, 17/70). The cellular immune function of reactivation group was significantly lower than that of non-reactivation group(P < 0.01). There was a significant difference (P=0.03) in 2-year survival rate between the activated and non-activated groups, and their survival rates were 35.9% and 53.3%, respectively. Conclusion: Some patients with primary hepatocellular carcinoma may have hepatitis B virus reactivation after receiving TACE treatment, and positive HBV DNA, immunosuppression were the risk factors for the development of HBV reactivation. Patients with hepatitis B virus reactivation after TACE have poor prognosis. The study suggests that antiviral therapy and immunoenhancer were necessary to improve curative effect and survival rate in HCC patients who underwent TACE.
Exogenous Sucrose Supply Regulates the Non-Structural Carbohydrate, Endogenous Hormone and Mineral Element Levels before the Flower Blooming and Fruit Abscission Stages in the Biodiesel Tree Sapindus mukorossi Gaertn.
Authors: Gao Yuan , Yang Ying , Gao Shilun , Jia Liming , Liu Shiqi , Weng Xuehuang 
Published: April 2020

Abstract
Background: Nutrient deficiency leads to a high fruit abscission rate in Sapindus mukorossi Gaertn. (Soapberry), which is one of the most widely cultivated biodiesel feedstock forests in China. Exogenous sucrose can provide a solution to nutrient deficiency and fruit abscission, which was applied to whole trees at two stages, 20 days before blooming (DBB stage) and fruit abscission (DBFA stage). Six sucrose concentrations, 0%, 1%, 1.5%, 3%, 5% and 7%, were sprayed three times at a completely randomized block design with 5 replications and 6 treatments. 13CO2 labelling experiments were carried out after the 3 sprayings. Results: (1) In the DBB stage, the 3% treatment significantly increased the inflorescence fructose and glucose contents 1-1.2 times, also resulted in the highest fruit GA3, leaf IAA, fruit IAA and fruit ZT contents, while it decreased the inflorescence ABA from 16 μg/g to 4 μg/g. (2) The 1.5% and 3% treatments significantly increased the carbohydrate content and decreased fruit ABA content to 30%-50% of the control level in the DBFA stage. (3) High-concentration sugar treatment (over 3%) increased the nitrogen, phosphorus, and potassium contents, which decreased the calcium and magnesium contents. (4) The 13C-dispatching ability of the inflorescence was 3 times greater than leaves under high-concentration sugar treatment in the DBB stage. Supplying 1.5% sucrose nearly doubled the allocation capacity in the DBFA stage. (5) The source-sink nutrient migration pathway showed that leaf and fruit sugars were directly correlated via phosphorus. Fruit fructose and glucose contents affected the leaf mineral element contents. Conclusions: It can conclude that exogenous application of 3% sucrose in the DBB stage and 1.5% sucrose in the DBFA stage can increase the sink nutrition allocation capacity, and phosphorus is the main mineral element correlated with leaf and fruit sugars.