bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nicht pharmakologische Sekundärprävention und Rehabilitation: aktuelle
Evidenz
Authors: Reibis Rona K. , Völler Heinz 
Published: June 2020

ZusammenfassungDie Sekundärprävention der koronaren Herzkrankheit umfasst einerseits eine
pharmakologische, andererseits eine lebensstilbasierte Säule, die idealerweise
interagieren und sich potenzieren. Neben der medikamentösen Blutdruck- und
Lipideinstellung auf leitlinienorientierte Zielwerte ermöglichen moderne
Antidiabetika eine Optimierung des glukometabolischen Kontinuums und eine
Prognosebesserung. Die Lebensstiloptimierung setzt sich aus koronarprotektiver
Ernährung, einer individualisierten Trainingstherapie, einer konsequenten
Nikotinkarenz und stressreduzierenden Maßnahmen zusammen. Die kardiologische
Rehabilitation (Phase II) schließt sich idealerweise unmittelbar einem stationären
Aufenthalt wegen eines akuten Koronarereignisses an, kann aber auch im Rahmen einer
stabilen Koronarsituation im Rahmen eines allgemeinen Antragsverfahrens durchgeführt
werden. Randomisierte und prospektiv angelegte Interventionsstudien belegen die
prognostische Wertigkeit der kardiologischen Rehabilitation auch im Zeitalter akuter
Revaskularisationstherapie mit 24-h-PCI und moderner Pharmakotherapie.
Recent Advances in the Molecular Imaging of Atherosclerosis
Authors: Larivière Mélusine , Bonnet Samuel , Lorenzato Cyril , Laroche-Traineau Jeanny , Ottonès Florence , Jacobin-Valat Marie-Josée , Clofent-Sanchez Gisèle 
Published: June 2020

AbstractAtherosclerosis is the major underlying cause of cardiovascular diseases, the prevalence of which is continuously increasing, thus currently standing as the leading global cause of death. This pathology gradually develops over the course of 50 or more years throughout the life of an individual under the influence of a vast number of factors, both environmental and pathophysiological. This wealth of factors has elicited much research into molecular imaging, with purely diagnostic purposes or with the hope of engineering an efficient theranostic tool. To these ends, diverse nanomaterials with desirable, tunable properties have been explored by different teams, as described in this review.
Tall-Statured Patients Have Similar Outcomes to Normal Height Patients after Primary Total Hip Arthroplasty
Authors: Siddiqi Ahmed , Warren Jared A. , Groover Michael , Santana Daniel , Anis Hiba K. , Kamath Atul F. , Molloy Robert M. , Higuera Carlos A. , Piuzzi Nicolas S. 
Published: June 2020

AbstractTotal hip arthroplasty (THA) has been proven to be a safe and efficacious operation; however, there is a paucity of literature on outcomes in patients in the 99th percentile for height. The objectives of this study were to identify differences in (1) implant selection, (2) operative times, (3) intraoperative and postoperative complications, (4) 90-day readmission, (5) all cause reoperation rates, and (6) hospital length of stay (LOS), in tall-statured patients compared with a matched control cohort. An electronic research request was used to identify 12,850 patients who underwent THA from January 2012 to December 2016 with minimum 1-year follow-up at a single health care system for retrospective chart review. Patients were identified in the 99th percentile for height (193 cm for males and 177 cm for females) and then matched to controls based on gender, race, age, body mass index, and Charlson comorbidity index. A total of 260 THA patients (2%) were identified in the 99th percentile for height. The tall-statured patients were then matched to 248 patients of normal stature. The exclusion criteria was met by 172 tall-statured patients and 165 normal-statured patients. Final analysis comprised of 86 tall-statured patients (100 THA) and 83 matched normal-statured patients (92 THA). Baseline demographics information and the outcomes of interest were then compared. The mean height of the female patients in the tall cohort was 181.01 ± 2.51 cm compared with 166.6 ± 6.98 cm for the control group (p < 0.001), while it was 195.25 ± 4.03 cm for male patients in the tall cohort and 174.11 ± 4.63 cm for the control cohort (p < 0.001). Tall-statured patients had larger acetabular cups (p < 0.001) and femoral head (p = 0.046) components. There were no differences in reoperation (p = 0.282), 90-day readmissions (p = 0.862), intraoperative fractures (p = 0.228), postoperative complications (p = 0.678), operative times (p = 0.890), and LOS (p = 0.099) between the tall-statured and normal-statured patients. Patients that are in the 99th percentile for height have similar outcomes to patients that are of normal height. The level of evidence of this study is level 3.
Universal Health Coverage in India: Where Rubber Hits the Road?
Authors: Nanjunda Devajana Chinnappa 
Published: June 2020

AbstractPoverty and healthcare issues are the most debatable topics today. Developing countries like India have as much as 45% of its population trapped in poverty because of various urgent healthcare needs. Universal health coverage (UHC) is a unique insurance system to provide financial protection to the marginalized groups of the country. It facilitates appropriate and immediate health needs, including required diagnostic, therapeutic and operational costs. However, UHC, a unique plan which focuses on the disadvantaged sections of the society, has some serious lacunae when it comes to its implementation in real life. This includes finances and human resources. Experts are reallocating adequate budgetary expenditure on healthcare issues, and in the meantime, a shortage of skilled health manpower is hunting down the UHC scheme in India. In recent times, different state governments are increasing budget allocation for the health sector. UHC is targeting low-income and poor families, forgetting the affordable and timely healthcare by way of improving services offered at the primary health centers and rapid expansion of the skilled health manpower across the country. UHC needs to focus on health paradigm systems, including improved healthcare-seeking behavior, nutrition, sanitation, potable water, reducing maternal and infant mortality, and dissemination of information of current technology to provide quality health services to the underserved and marginalized population of the country. These changes would symbolize a real way forward toward the immediate fulfillment of UHC goals for India.
Staging of Locally Advanced Rectal Cancer Beyond TME
Authors: Keller Deborah S. 
Published: June 2020

AbstractThe management of rectal cancer is complex and continually evolving. With advancements in technology and the use of multidisciplinary teams to guide the treatment decision making, staging, oncologic, and functional outcomes are improving, and the management is moving toward personalized treatment strategies to optimize each individual patient's outcomes. Key in this evolution is imaging. Magnetic resonance imaging (MRI) has emerged as the dominant method of pelvic imaging in rectal cancer, and use of MRI for staging is best practice in multiple international guidelines. MRI allows a noninvasive assessment of the tumor site, relationship to surrounding structures, and provides highly accurate rectal cancer staging, which is necessary for determining the appropriate treatment strategy. However, the applications of MRI extend far beyond pretreatment staging. MRI can be used to predict outcomes in locally advanced rectal cancer and guide the surgical or nonsurgical plan, serving as a predictive and prognostic biomarker. With continued MRI hardware improvement and new sequence development, MRI may offer new perspectives in the assessment of treatment response and new innovations that could provide better insight into the staging, restaging, and outcomes with rectal cancer.
The ABO Locus is Associated with Increased Fibrin Network Formation in Patients with Stable Coronary Artery Disease
Authors: Winther-Larsen Anne , Christiansen Morten Krogh , Larsen Sanne Bøjet , Nyegaard Mette , Neergaard-Petersen Søs , Ajjan Ramzi A. , Würtz Morten , Grove Erik Lerkevang , Jensen Henrik Kjærulf , Kristensen Steen Dalby , Hvas Anne-Mette 
Published: June 2020

Abstract
Background The ABO locus has been associated with increased risk of myocardial infarction (MI) in patients with coronary artery disease (CAD), but the underlying mechanisms are unknown. As altered fibrin clot structure has been demonstrated to predict MI in CAD patients, we examined the association between the ABO risk variant and fibrin clot properties, and investigated the effects of other CAD-associated risk variants.
Methods We included 773 stable CAD patients. Patients were genotyped for 45 genome-wide CAD risk variants, including rs495828 at the ABO locus. We used a genetic risk score (GRS) for CAD calculated as the weighted sum of the number of risk alleles based on all 45 variants. Fibrin clot properties were evaluated using a turbidimetric assay. We studied clot maximum absorbance, a measure of clot density and fiber thickness, together with clot lysis time, an indicator of fibrinolysis potential.
Results The rs495828 risk allele was present in 13.2% of patients and associated with higher clot maximum absorbance (adjusted effect size per risk allele: 1.05 [1.01 − 1.09], p = 0.01) but not with clot lysis time (p = 0.97). The rs12936587 (p = 0.04), rs4773144 (p = 0.02), and rs501120 (p = 0.04) were associated with clot lysis time; however, after Bonferroni correction, no significant associations were found between any of the remaining 44 CAD-associated variants and fibrin clot properties. The GRS was not associated with fibrin clot properties (p-values > 0.05).
Conclusion The ABO risk allele was associated with a more compact fibrin network in stable CAD patients, which may represent a mechanism for increased MI risk in ABO risk variant carriers.
Acupuncture points and perforating cutaneous vessels identified in the upper limb using infrared thermography
Authors: Soares-Parreira F. , Álvarez-Prats D. , Carvajal-Fernández O. , Barbosa-Pereira M. , Valera-Garrido F. 
Published: June 2020

Abstract
Objective To verify the presence of perforating cutaneous vessels (PCV) among different acupuncture points (AP) of the upper limb by means of infrared thermography (IT).
Material and Methods An analytical observational cross-sectional study examining the upper limb of volunteer subjects (n = 7). A total of 91 AP were analyzed, as well as 91 control points (CP), one for each AP. In each subject, first, the AP and their corresponding CP were marked and, second, the thermographic images were taken. The images were then processed using the Physio Thermal Imaging (PTI) software, observing the presence or absence of these PCV on the AP and corresponding CP.
Results PCV were identified in 68.1% of the total 91 AP examined. However, despite the strong trend in the presence of PCV in the studied AP, certain AP did not display significant differences with their corresponding CP.
Conclusions This study shows a certain correlation between the PCV and the AP chosen in this sample, due to the high presence of PCV in the AP. IT is a useful tool during physical therapy treatment procedures using acupuncture.
Prevalent Eurasian avian-like H1N1 swine influenza virus with 2009 pandemic viral genes facilitating human infection
Authors: Sun Honglei , Xiao Yihong , Liu Jiyu , Wang Dayan , Li Fangtao , Wang Chenxi , Li Chong , Zhu Junda , Song Jingwei , Sun Haoran , Jiang Zhimin , Liu Litao , Zhang Xin , Wei Kai , Hou Dongjun , Pu Juan , Sun Yipeng , Tong Qi , Bi Yuhai , Chang Kin-Chow , Liu Sidang , Gao George F. , Liu Jinhua 
Published: June 2020

Significance
Pigs are intermediate hosts for the generation of pandemic influenza virus. Thus, systematic surveillance of influenza viruses in pigs is a key measure for prewarning the emergence of the next pandemic influenza. Here, we identified a reassortant EA H1N1 virus possessing pdm/09 and TR-derived internal genes, termed as G4 genotype, which has become predominant in swine populations since 2016. Similar to pdm/09 virus, G4 viruses have all the essential hallmarks of a candidate pandemic virus. Of concern is that swine workers show elevated seroprevalence for G4 virus. Controlling the prevailing G4 EA H1N1 viruses in pigs and close monitoring in human populations, especially the workers in swine industry, should be urgently implemented.
Oral squamous cell carcinoma diagnosed from saliva metabolic profiling
Authors: Song Xiaowei , Yang Xihu , Narayanan Rahul , Shankar Vishnu , Ethiraj Sathiyaraj , Wang Xiang , Duan Ning , Ni Yan-Hong , Hu Qingang , Zare Richard N. 
Published: June 2020

SignificanceWe show that the combination of conductive polymer spray mass spectrometry (CPSI-MS) and machine learning provides a simple, fast, and affordable method for oral squamous cell carcinoma diagnosis with 86.7% accuracy. By using CPSI-MS, the direct, high-throughput metabolic profiling of saliva can be readily realized in a noninvasive manner. The self-conductive materials used in CPSI-MS for sample loading and ionization are clean, cheap, and consumable for cohort analysis. Wide coverage of chemical species provides not only the pools of possible metabolite signatures for molecular diagnosis but also the possibility of exploring metabolite function and oncological mechanism. The analysis of saliva samples from 373 individuals was completed within 4.5 h, satisfying the technical demand for point-of-care testing.
Sex differences in neutrophil biology modulate response to type I interferons and immunometabolism
Authors: Gupta Sarthak , Nakabo Shuichiro , Blanco Luz P. , O’Neil Liam J. , Wigerblad Gustaf , Goel Rishi R. , Mistry Pragnesh , Jiang Kan , Carmona-Rivera Carmelo , Chan Diana W. , Wang Xinghao , Pedersen Hege L. , Gadkari Manasi , Howe Katherine N. , Naz Faiza , Dell’Orso Stefania , Hasni Sarfaraz A. , Dempsey Caeden , Buscetta Ashley , Frischmeyer-Guerrerio Pamela A. , Kruszka Paul , Muenke Maximilian , Franco Luis M. , Sun Hong-Wei , Kaplan Mariana J. 
Published: June 2020

Significance
Despite clear differences in female and male immunity that may contribute to variations in response to infections and predisposition to cancer and autoimmunity, the exact mechanisms that drive this stark contrast remain insufficiently characterized. Neutrophils play essential roles in homeostasis and disease, but little is known about how sex differences modulate their phenotype and function. Using transcriptomic and functional approaches, we report that healthy young adult females have an activated/mature neutrophil profile characterized by enhanced type I IFN pathway activity, enhanced proinflammatory responses, and distinct bioenergetics. We further show that these differences are cell specific and likely driven by sex hormones. Modulation of these pathways in neutrophils may provide more individualized, sex-specific therapeutic options in a variety of disease states.
Observing the nonvectorial yet cotranslational folding of a multidomain protein, LDL receptor, in the ER of mammalian cells
Authors: Kadokura Hiroshi , Dazai Yui , Fukuda Yo , Hirai Naoya , Nakamura Orie , Inaba Kenji 
Published: June 2020

SignificanceMultidomain proteins constitute more than two-thirds of all proteome. To decrease the risk of misfolding, these proteins generally fold vectorially as each domain emerges from the ribosome or protein translocation channel. Interestingly, however, some cell surface multidomain proteins including the low-density lipoprotein receptor (LDLR) fold in the ER nonvectorially via intermediates with nonnative disulfides. Shuffling of nonnative disulfides to native ones, a key step in their folding, has been thought to proceed slowly after synthesis. Here, we find that disulfide shuffling in LDLR occurs at a specific timing during synthesis in a manner depending on a downstream region of the polypeptide. Thus, nonvectorial folding of multidomain proteins in the endoplasmic reticulum (ER) may be more coordinated and elaborated than thought.
Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface
Authors: Shigdel Uddhav K. , Lee Seung-Joo , Sowa Mathew E. , Bowman Brian R. , Robison Keith , Zhou Minyun , Pua Khian Hong , Stiles Dylan T. , Blodgett Joshua A. V. , Udwary Daniel W. , Rajczewski Andrew T. , Mann Alan S. , Mostafavi Siavash , Hardy Tara , Arya Sukrat , Weng Zhigang , Stewart Michelle , Kenyon Kyle , Morgenstern Jay P. , Pan Ende , Gray Daniel C. , Pollock Roy M. , Fry Andrew M. , Klausner Richard D. , Townson Sharon A. , Verdine Gregory L. 
Published: June 2020

Significance
This manuscript reports on a member of the FK506/rapamycin family, WDB002, and the realization that FKBP-mediated recognition is a genetically programmable modality that enables engagement of topologically flat targets. FKBP-mediated recognition is thus nature’s strategy for drugging the “undruggable.” The surface of FKBP engages three completely unrelated targets—calcineurin, MTOR, and CEP250—with high-target affinity and specificity, using different constellations of amino acid residues. Target specificity is determined solely by the “variable domain” of the bound small molecule alone, suggesting the modality might be generalizable to other undruggable targets through variable domain engineering. Finally, since WDB002 targets CEP250, it may be a promising starting point for developing a treatment for COVID-19.
Halal Risk Analysis at Indonesia Slaughterhouses Using the Supply Chain Operations Reference (SCOR) and House of Risk (HOR) Methods
Authors: Wahyuni D , Nasution A H , Budiman I , Arfidhila N 
Published: June 2020

Abstract
The Halal supply chain is one of the most important factors for Muslim because the product to be consumed must be halal, from the source to the end consumers. This research was conducted at several feedlots (fattening cattle), slaughterhouses (RPH), and traditional markets in the city of Medan and surrounding areas. In this study identified all activities in the slaughterhouse, activity mapping, determination of risk events, risk agents, and Aggregate Risk Potential (ARP) calculations in the red meat supply chain with the adoption of the SCOR model namely plan, source, make, deliver, and return and HOR (House of Risk). The results showed that there were 19 activities (sub-processes), 28 risk events and 28 risk agents. The selected risk agents based on the five highest ARP values are less cleaned floor after slaughtering (Ag17), the accumulation of blood into clots (Ag20), lack of machine maintenance management (Ag2), too many cattle to be slaughtered (Ag3), and increased consumer demand (Ag1). Knowing the risks and causes of risks will facilitate handling so that supply chain performance can be improved. It is necessary to study appropriate risk mitigation actions so that risk events can be reduced.
Distribution improvement in achieving customer satisfaction
Authors: Sembiring N , Tarigan U , Tiana Y W , Nasution M A 
Published: June 2020

Abstract
A good distribution can be used to achieve various goals ranging from supply chain gain low cost until it gets a response to high customer satisfaction. In addition to the above issues, transport routes is a constraint that cannot be allowed. Without a good transportation system, logistics could not bring the full benefit for the company. In addition, a good transportation system in logistics activities could provide logistical efficiency, reduce operating costs, and improve service quality by using Distribution Requirement Planning Method.
Network Distribution in Processing Customer Order
Authors: Sembiring N , Sinaga T S , Nasution M A. 
Published: June 2020

Abstract
In shipping goods, companies must have a basis for scheduling and determining routes correctly, thus speeding up product delivery times and saving product shipping costs. There are so many routes that companies can choose in distributing their products, and require different costs, for that the company need a method that can analyze product distribution in order to minimize the time, distance and cost. Transportation provides geographical benefits to logistics systems by connecting facilities with markets.
Evaluation of Proximate Composition and Color of Rabbit Feed with Combinations Moringa Leaves Flour and Guava Leaves Flour
Authors: Siregar G A W , Mirwandhono R E , Patriani P , Ginting N 
Published: June 2020

Abstract
This study aims to analyze the proximate composition and color of the rabbit feed. This research method uses a kinetic method that starts with drying, mixing ingredients and pelleting. The next step is to analyze rabbit feed in combination (0:0; 0:15; 5:10; 10: 5; 15: 0)% moringa leaves flour and guava leaves flour. The research parameters observed included: the determination of protein, crude fiber, crude fat, water, ash, calcium, and phosphorus. This research uses a completely randomized design. The results showed that the combination of moringa leaves flour and guava leaves flour affected the proximate composition and color of rabbit pellets. The combination (5:10)% of moringa leaves flour and guava leaves flour has the best proximate composition and dark chocolate colour.
Design, Build, and Aanalytical Simulation of Carbon Monoxide Gas Emission Measuring Instrument Based on Smartphone with Linear Regression Approach
Authors: Hakim L , Siahaan D A S 
Published: June 2020

Abstract
To find out the level of carbon monoxide gas emission in motor vehicles, we need a tool that can measure these conditions. So in this study made a measuring tool for carbon monoxide gas emission levels in motor vehicles. This measurement tool uses the TGS 2442 sensor. While Arduino Uno as a microcontroller and signal processor, and Android smartphone as a data viewer. Based on the sensor testing obtained, the graphs obtained linear equations when measuring carbon monoxide levels in BK 6776 PAN cars y_reg = 38.436-0.0641x with standard deviation values (δ) = 10.816, uncertainty values of measurement results (UA_1) = 6.245 and uncertainty values regression approach UA_2 = 1.02 and on vehicles with BK 6281 AAG y_reg = -3371 + 1.03x with a standard deviation value (δ) = 157.25, the uncertainty value of the measurement results (UA_1) = 90.788 and the uncertainty value of the UA_2 regression approach = 28185.05 and on vehicles BK 3181 MAM y_reg = -24.48 + 0.001x with a standard deviation value (δ) = 99.168, the uncertainty value of the measurement results (UA_1) = 57.255 and the uncertainty value of the regression approach UA_2 = 3824.05. Retrieval of data on the measuring instrument that the standard deviation value at 10 seconds is 2375.32, at 12 seconds is 3318.42, and at 15 seconds is 2639,813. The measurement uncertainty value at 10 seconds is 1371.39, at 12 seconds is 1915.89 and at 15 seconds is 1524.1
Reproduction biology of Baung Suat fish (Hemibagrus caveatus) in the downstream of Batangtoru river
Authors: Desrita  , Muhtadi A , Leidonald R 
Published: June 2020

Abstract
Baung Suat fish (Hemibagrus caveatus) become the newest species in North Sumatera. H. caveatus were collected in Batangtoru downstream. This species has a special mark, specifically a horizontal and vertical strip both on the left and right of the body of this species. The research has been done at Batangtoru downstream, North Sumatera in July 2019. The total amount of this captured fish was53 fish with 170 mm to 394 mm in total length (TL). The value of constant b obtained from the relationship length weight of H. caveatus fish was 3.09 which makes H. caveatus are positive allometric. Condition Factor values obtained based on the relation of body length and weight about 0,8098 – 1,3527. Sex ratio between male and female are 1,41. The male of H. caveatus are at the Gonado Maturity Level (GML) I, II, III, and IV, while the female at GML III and IV. Gonado Maturity Index (GMI) of H. caveatus at 2,46 – 13,07 %. The first size maturity of gonad begins to appear in 291,27 mm length for the male and 303,32 mm length for the female.