bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gandhi’s Spiritual Politics: Austerity, Fasting and Secularism
Authors: Farooqui Amar 
Published: October 2020

This article attempts to explore the connection between Gandhi’s spiritual quest, of which abstinence was a major component, and his politics. Gandhi was a deeply religious person. His politics, however, was secular in that it had little to do with the politics of religious identity. He would have found the notion of engaging in the politics of religious identity revolting, something that is borne out by his political practice. It was at the moment of the greatest crisis during the final phase of the anti-colonial struggle that he articulated his position with great clarity, and then went on to give it meaning through his presence in the countryside of Noakhali, and the refugee camps of Delhi. The influences of the social milieu of his early life in Saurashtra, and the colonial condition, shaped his world view in significant ways. The concrete everyday experiences of his early life are useful for comprehending his ideas about austerity as a moral ideal. There was a close link between austerity and the endeavour to achieve control over the palate. Besides, the story of his long association with his childhood friend Sheikh Mehtab is revisited, in the light of recent research, to see how it might allow a better understanding of this link.
Prevention of platelet aggregation and arterial thrombosis using a modified Shenzhu Guanxin Formula
Authors: Huang Manting , Wu Huanlin , Wu Jianping , Chen Qiuxiong , Zou Dezhi , Xu Danping 
Published: October 2020

Objective Modified Shenzhu Guanxin Formula (mSGF) has beneficial effects in coronary artery disease. Previously, we found that mSGF inhibited platelet aggregation in rats. In the present study we further investigated the antiplatelet and antithrombotic activities of mSGF in rats. Methods Rats were orally administered mSGF (4.2, 8.4, or 16.8 g crude drug/kg), the adenosine 5′-diphosphate (ADP) receptor antagonist clopidogrel (7.875 mg/kg), or saline once a day for 7 days. The effects of mSGF on platelet aggregation were measured. Levels of cyclic adenosine monophosphate (cAMP) and phosphoinositide 3-kinase (PI3K) signaling were analyzed by ELISA and western blotting, respectively. The antithrombotic effect of mSGF was investigated using a FeCl3-induced carotid arterial thrombosis model and effects on bleeding time were assessed in a rat tail transection model. Results mSGF significantly inhibited ADP-induced platelet aggregation in a dose-dependent manner, elevated cAMP levels and inhibited phosphorylation of extracellular signal-regulated kinase (ERK) and PI3K/protein kinase B (Akt). Moreover, mSGF dose-dependently inhibited thrombosis in a FeCl3-induced carotid arterial thrombus model and had a significantly smaller effect on bleeding time compared with clopidogrel. Conclusions mSGF represents a potent and safe antithrombotic agent whose antiplatelet activity is probably mediated through blockade of PI3K/Akt signaling and increased cAMP generation.
Risk factors and prognosis of nosocomial pneumonia in patients undergoing extracorporeal membrane oxygenation: a retrospective study
Authors: Wang Jianrong , Huang Jinyu , Hu Wei , Cai Xueying , Hu Weihang , Zhu Ying 
Published: October 2020

Objective We aimed to examine the risk factors and prognosis of nosocomial pneumonia (NP) during extracorporeal membrane oxygenation (ECMO). Methods We retrospectively analyzed data of patients who received ECMO at the Affiliated Hangzhou Hospital of Nanjing Medical University between January 2013 and August 2019. The primary outcome was the survival-to-discharge rate. Results Sixty-nine patients who received ECMO were enrolled, median age 42 years and 26 (37.7%) women; 14 (20.3%) patients developed NP. The NP incidence was 24.7/1000 ECMO days. Patients with NP had a higher proportion receiving veno-venous (VV) ECMO (50% vs. 7.3%); longer ECMO support duration (276 vs. 140 hours), longer ventilator support duration before ECMO weaning (14.5 vs. 6 days), lower ECMO weaning success rate (50.0% vs. 81.8%), and lower survival-to-discharge rate (28.6% vs. 72.7%) than patients without NP. Multivariable analysis showed independent risk factors that predicted NP during ECMO were ventilator support duration before ECMO weaning (odds ratio [OR] = 1.288; 95% confidence interval [CI]: 1.111–1.494) and VV ECMO mode (OR = 10.970; 95% CI: 1.758–68.467). Conclusion NP during ECMO was associated with ventilator support duration before ECMO weaning and VV ECMO mode. Clinicians should shorten the respiratory support duration for patients undergoing ECMO to prevent NP.
Entrepreneurial Orientation and Small and Medium-sized Enterprises’ Performance; Does ‘Access to Finance’ Moderate the Relation in Emerging Economies?
Authors: Khan Rizwan Ullah , Salamzadeh Yashar , Kawamorita Hiroko , Rethi Gabor 
Published: October 2020

The main objective of the underline study is to examine the influence of entrepreneurial orientation (EO) on financial and non-financial performance of small and medium-sized enterprises (SMEs) with the moderating role of access to finance. Because SMEs—due to fair reasons such as lack of resources and lack of managerial skill—are often unable to succeed in their mission, the managers look for much less risky and convenience factors to compete in the market. A variety of factors has been tested but the role of finance in this perspective has received minor attention. Hence, the underline study tested finance as a moderator between firm resources and their performance. To test the model, a structured questionnaire is used to collect data from 326 Pakistani SMEs. Structural equation modelling in AMOS is used to test the hypotheses. Our finding suggests that EO significantly enhances SME’s financial and non-financial performance in emerging economies. On the other hand, access to finance significantly moderates the relationship between EO and SME’s financial performance while it is not significantly moderating between EO and non-financial performance. This research recommends policymakers and practitioners to focus on accessing adequate finance while Small and Medium-sized Enterprises Development Authority encourages banks and financial institutions to facilitates SMEs. Furthermore, the possible implications have been discussed.
Analysis of Tumor Depth Invasion With Anti-Smoothelin Antibody in Equivocal Transurethral Resection of Urinary Bladder Tumor Surgical Specimens
Authors: Mihai Ioana Maria , Olteanu Gheorghe-Emilian , Herman Diana , Anderco Denisa , Iacob Mihaela , Nataras Bianca , Cumpanas Alin Adrian , Bardan Razvan , Dema Alis 
Published: October 2020

Objective To examine the expression and value of the smoothelin marker in control cases, to standardize the working method, and to analyze its application in pathologic staging process of problematic transurethral resection of bladder tumor (TURBT) cases. Material and Methods Immunohistochemical (IHC) staining was performed on tumor-free bladder wall sections, tumor-free large bowel sections, TURBTs with unequivocal tumor stage, and TURBTs with equivocal stage. The IHC staining of muscularis mucosa (MM), muscularis propria (MP), and blood vessels was evaluated semiquantitatively. Results Smoothelin IHC staining pattern ranged from negative (30% to 67% cases) to 2+ (0% to 15% cases) in MM and from 1+ (10% to 50% cases) to 3+ (9% to 48% cases) in MP. When compared on the same slide, the smoothelin expression of MP showed a stronger staining intensity than the one of the MM in all the analyzed cases. Blood vessel muscle cells stained in a constant intensity as the MM ( r = 0.9808; r = 0.9604). Smoothelin determined restaging of 33% of the problematic TURBT cases. Conclusion Smoothelin is an IHC marker that shows differential staining between coexistent MM and MP; however, variations in staining intensity and pattern may occur, aspects that can be influenced by different technique variables. We recommend using this marker as a diagnostic tool in problematic TURBT cases only when there is sufficient experience in control cases with this antibody.
Physical modeling and experimental verification of magneto-rheological damper under medium and high frequency excitation
Authors: Xu Fanghui , Dong Dawei , Huang Yan , Song Shizhe , Yan Bing 
Published: October 2020

As a promising semi-active device, magneto-rheological damper has been widely used in low-frequency vibration isolation fields (within 20 Hz) such as bridge damping and building seismic resistance. Recently, the application of magneto-rheological damper has extended to medium and high frequency fields such as satellite and power engine vibration control, accompanied with an urgent need of detailed understanding of its output characteristics. In this paper, a comprehensive physical model is established to analyze dynamic performance of the magneto-rheological damper. The model, derived from both Poiseuille and Couette flow, aims to describe the relationship between the flow rate and pressure difference. The compressibility of the magneto-rheological fluid, the inertia of both the fluid and piston assembly, and the friction are involved to capture the medium and high frequency dynamics of the damping force. Theoretical calculation and simulation verification of magnetic circuit are conducted. Then the experiment based on a self-made prototype is carried out. The results show that the damping force calculated by proposed physical model matches well with the experimental results across the predefined range of frequency and coil current levels.
Forgoing life sustaining treatment decision-making in critically ill children: Parental views and factor’s influence
Authors: Nurnaningsih Nurnaningsih , Setiyarini Sri , Al Mirzanah Syafa’atun , Padmawati Retna Siwi , Juffrie Mohammad 
Published: October 2020

Objective Explore parents’ point of view about forgoing life sustaining treatment (LST) in terminal critically ill children and factors affecting their decisions. Method This was a qualitative study using in-depth interviews with parents whose child died between 6–12 months old in pediatric intensive care unit (PICU) of a university-affiliated teaching hospital. Interviews were audiotaped and transcribed. Data were analyzed using interpretive description method. Result A total of 7 parents of 5 children decided to withhold or withdraw LST. Five parents from 4 children decided to sign the do not attempt resuscitation (DNAR), and none choose to withdrew the LST, including mechanical support. Factors influenced their decision were communication, value of children, child best interest, intuition, religious belief, and emotions. Economic factors did not influence the decision-making. Conclusion Most parents decided to sign the DNAR, none choose to withdrew mechanical support. Communication was the most important factor that influenced parents to make a forgoing LST decision.
Prediction of Poor Prognosis of HCC by Early Warning Model for Co-Expression of miRNA and mRNA Based on Bioinformatics Analysis
Authors: Su Zi-jian , Lin Chun-cheng , Pan Jian-hui , Zhang Jian-hua , Han Tao , Pan Qunxiong 
Published: October 2020

Objective: Hepatocellular Carcinoma (HCC) has the highest mortality rate worldwide with the intractability of its extremely complicated pathogenesis and unclear mechanism. The limited survival highlights the need for the further detection of prognosis for HCC. MicroRNAs (miRNAs) and messenger RNAs (mRNAs) have been identified as regulatory factors and target genes in human cancers, while some studies also found post-transcriptional modification plays a crucial role in the occurrence and development of HCC. The present study aimed to elucidate the prognostic significance of miRNA and mRNA models in HCC. Methods: Data were obtained from The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC), and Gene Expression Omnibus (GEO) databases. The miRNA and mRNA expressions were tested by the Wilcoxon and used funrich software to predict mRNA that might be related to miRNA. Then we determined the intersection with overlapped mRNA and miRNA Venn diagram, and screened out hub gene by using Degree algorithm in Cytoscape software. The COX models, with TCGA data as the training set and ICGC data as the test set, were constructed. All patients were divided into high-risk and low-risk groups. Data on overall survival of different groups were collected and analyzed by Kaplan-Meier method, and independent risk factors affecting prognosis were assessed by Cox analysis. Results: The miRNA and mRNA polygenic risk model showed a good true positive rate. Kaplan-Meier curve and Cox analysis suggested that the high-risk group was associated with poor prognosis, and the risk score could be used as an independent risk factor for HCC. Conclusion: Tumor risk models constructed in this study could effectively predict the prognosis of patients, which is expected to provide a reference for the prognostic stratification and treatment strategy development of HCC.
Caregivers’ Dementia Knowledge and Care Approach in Residential Aged Care Facilities in China
Authors: Dai Yunyun , Zhao Jia , Li Shenmei , Zhao Chaochao , Gao Yan , Johnson Claire Elizabeth 
Published: October 2020

Objective: To investigate the dementia knowledge and care approach used by caregivers in residential aged care facilities (RACFs) in China. Method: A cross-sectional survey of 785 caregivers from a random sample of 34 RACFs in China. Caregivers’ knowledge and care approach were assessed using the Chinese version of the Dementia Knowledge Assessment Tool 2 and Advanced Dementia Care Questionnaire. Results: The majority of caregivers showed limited knowledge of dementia and tended not to adopt a person-centered approach to care. Educational level, dementia care training, and years of work experience were positively associated with dementia knowledge. Educational level and years of work experience were also associated with a person-centered approach to care. Conclusions: This study provides insight into the care available to people with dementia in RACFs in China. The results suggest dementia care education programs as well as person-centered care training are urgently needed for caregivers in China.
Sinus Irrigation Penetration After Proposed Modified Draf IIa Technique in a Side-to-Side Cadaveric Model
Authors: Issa Khalil , Teitelbaum Jordan I. , Jang David W. , Goldstein Bradley J. , Chan Lyndon , Hachem Ralph Abi 
Published: October 2020

Background Endoscopic sinus surgery (ESS) is an effective intervention for patients with medically refractory chronic rhinosinusitis. Frontal sinusotomy is the most challenging part of ESS, with one of the key outcomes being access for topical irrigations. Objective The purpose of this study is to compare irrigation penetration into the frontal sinus following Draf IIa versus modified Draf IIa frontal sinusotomy. Methods Four fresh cadaver heads were used in this experiment. Draf IIa was performed on one side of each head and a modified Draf IIa on the contralateral side. This proposed modification consists of a Draf IIa combined with an agger nasi punch-out procedure and partial trimming of the vertical lamella of the middle turbinate back to the posterior table of the frontal sinus without drilling the beak. Each head was irrigated with methylene blue-dyed water and recorded by rigid endoscopy through an endonasal view (EV) of the frontal sinus and frontal trephination view (TV). Two blinded rhinologists scored the extent of staining (using an ordinal scale of 0 to 3) for each side. A case report where the modified Draf IIa was performed is also described. Results After modified Draf IIa sinuosotomy, the mean score for the EV was 2.125 and for the TV was 2, versus 0.875 and 0.625 for traditional Draf IIa, respectively. There was a statistically significant increase for both EV (p = 0.019) and TV (p = 0.018) after modified Draf IIa. Conclusion In our cadaveric model, this procedural modification improved penetration of postoperative irrigations into the frontal sinus. This simple technique may be easily adapted into frontal ESS when indicated.
SMURF1 and SMURF2 in Progenitor Cells from Articular Cartilage and Meniscus during Late-Stage Osteoarthritis
Authors: Schminke Boris , Kauffmann Philipp , Schubert Andrea , Altherr Manuel , Gelis Thomas , Miosge Nicolai 
Published: October 2020

Objective The aim of this study was to investigate the roles of SMURF1 and SMURF2 in progenitor cells from the human knee in late-stage osteoarthritis (OA). Design We applied immunohistochemistry, immunocytochemistry, RNAi, lentiviral transfection, and Western blot analysis. We obtained chondrogenic progenitor cells (CPCs) from the articular cartilage and meniscus progenitor cells (MPCs) from the nonvascularized part of the meniscus. Results SMURF1 and SMURF2 appeared in both osteoarthritic tissues. CPCs and MPCs exhibited comparable amounts of these proteins, which influence the balance between RUNX2 and SOX9. The overexpression of SMURF1 reduced the levels of RUNX2, SOX9, and TGFBR1. The overexpression of SMURF2 also reduced the levels of RUNX2 and TGFBR1, while SOX9 levels were not affected. The knockdown of SMURF1 had no effect on RUNX2, SOX9, or TGFBR1. The knockdown of SMURF2 enhanced RUNX2 and SOX9 levels in CPCs. The respective protein levels in MPCs were not affected. Conclusions This study shows that SMURF1 and SMURF2 are regulatory players for the expression of the major regulator transcription factors RUNX2 and SOX9 in CPCs and MPCs. Our novel findings may help elucidate new treatment strategies for cartilage regeneration.
Effects of Mesenchymal Stem Cells Therapy on Cardiovascular Risk Factors in Experimental Diabetic Kidney Disease
Authors: Hussein Einas Nagib , Hamed Gehane M. , Seif Ansam A. , Ahmed Mona A. , Abu Zahra Fatma Abd Elkarim 
Published: October 2020

Background: Diabetic kidney disease (DKD) is a progressive kidney disease and a leading cause of end-stage renal disease (ESRD). Diabetic kidney disease has been strongly associated with increased risk of cardiovascular morbidity and mortality. Despite their susceptibility to cardiovascular diseases (CVDs), patients with DKD are less likely to receive appropriate cardiovascular risk modification as they are generally excluded from major cardiovascular trials. Awareness of vulnerability of these patients necessitates investigating potential interventions that would lessen their risk of adverse outcomes. Objectives: This study aimed to explore the effect of bone marrow–derived mesenchymal stem cells (MSCs) in modulating cardiovascular risk factors that develop with the progression of DKD. Methods: A total of 60 adult female albino rats were allocated into 3 groups: control group, untreated DKD group, and mesenchymal stem cells–treated diabetic kidney disease (MSCs-DKD) group. Blood pressure, blood glucose level, lipid profile, and atherogenic index were used to assess cardiovascular risk. All rats were killed and subjected to in vitro aortic reactivity studies 8 weeks after induction of diabetes. The MSCs-DKD rats received a single intravenous injection of MSCs 4 weeks after diabetes induction. Results: Mesenchymal stem cells injection significantly decreased blood pressure, atherogenic index, and blood glucose compared with untreated rats. The MSCs-DKD aorta also exhibited significant enhancement of vascular reactivity parameters despite absence of improvement in kidney function. These findings conformed to tracked MSCs, which were found residing in aortic and pancreatic tissues and absent in kidneys. Conclusions: Mesenchymal stem cells hold hope of improving cardiovascular risk and mortality in patients with DKD, particularly those deteriorating to ESRD.
Taking a Closer Look at Mental Health Treatment Differences: Effectiveness of Mental Health Treatment by Provider Type in Racial and Ethnic Minorities
Authors: Henry Tracey L. , Jetty Anuradha , Petterson Stephen , Jaffree Helaina , Ramsay Allie , Heiman Erica , Bazemore Andrew 
Published: October 2020

Objectives: To estimate racial/ethnic differences in the extent to which mental health treatment is obtained from mental health providers, primary care physicians (PCPs), or both and to examine the effects of provider type on change in mental component scores (MCS) of the SF-12 on different race/ethnic groups. Methods: Secondary data analysis of 2008 to 2015 Medical Expenditure Panel Survey (MEPS). Non-institutionalized civilian US population, aged 18 to 64 (N = 62 558). Based on counts of all mental health visits in a calendar year, we identified patients who obtained care from PCPs, mental health provider, PCP and mental health providers and other providers and examined changes in MCS by type of care. Results: 9.9% of Non-Hispanic Whites obtained mental health treatment, compared to 5.0% for Hispanics, 5.3% for Blacks and 5.5% for Other Races ( P < .001). Non-Hispanic Blacks and non-Hispanic “Other” were more likely than other groups to obtain care from mental health providers only ( P = .017). All obtaining care solely from PCP had better mental health (mean (se)) MCS: 43.2(0.28)) than those obtaining care solely from mental health provider (39.8 (0.48)), which in turn was higher than for those obtaining care from both PC and MH providers (38.5 (0.31), ( P < .001). Conclusion: Even when diagnosed with a mental health disorder, Hispanics and Blacks were less likely to seek mental health treatment than Whites, highlighting the continuing disparity. Future research should focus on understanding how and what aspects of integrated care models and other mental health delivery models that reduce disparities and provide greater accessibility.
What Do We Know About Changing Economic Activity of Firms?
Authors: Pandey Radhika , Sapre Amey , Sinha Pramod 
Published: October 2020

Identification of primary economic activity of firms is a prerequisite for compiling several macro aggregates. In this paper, we take a statistical approach to understand the extent of changes in primary economic activity of firms over time and across different industries. We use the history of economic activity of over 46,000 firms spread over 25 years from CMIE Prowess to identify the number of times firms change the nature of their business. Using the count of changes, we estimate Poisson and Negative Binomial regression models to gain predictability over changing economic activity across industry groups. We show that a Poisson model accurately characterizes the distribution of count of changes across industries and that firms with a long history are more likely to have changed their primary economic activity over the years. Findings show that classification can be a crucial problem in a large data set like the MCA21 and can even lead to distortions in value addition estimates at the industry level. JEL Classifications: D22, E00, E01