bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects on the Post-translational Modification of H3K4Me3, H3K9ac, H3K9Me2, H3K27Me3, and H3K36Me2 Levels in Cerebral Cortex, Hypothalamus and Pons of Rats after a Systemic Administration of Cannabidiol: A Preliminary Study
Authors: Pastrana-Trejo José Carlos , Duarte-Aké Fátima , Us-Camas Rosa , De-la-Peña Clelia , Parker Linda , Pertwee Roger G. , Murillo-Rodríguez Eric 
Published: September 2020

Background:
Cannabidiol (CBD), a non-psychotropic constituent of Cannabis sativa,
has shown therapeutic promises by modulating several pathological conditions, including pain,
epilepsy autism, among others. However, the molecular mechanism of action of CBD remains unknown
and recent data suggest the engagement on CBD´s effects of nuclear elements, such as histone
activity.

Aim:
This study assessed the changes in the post-translational modification (PTM) on the histones
H3K4Me3, H3K9ac, H3K9Me2, H3K27Me3, and H3K36Me2 in several brain regions of rats after
the administration of CBD (20 mg/Kg/i.p.).

Objective:
To evaluate the effects on the PTM of histones H3K4Me3, H3K9ac, H3K9Me2,
H3K27Me3, and H3K36Me2 levels in the cerebral cortex, hypothalamus and pons of CBD-treated
rats.

Methods:
Ten adult rats were randomly assigned into 2 groups: Control or CBD (20 mg/Kg/i.p).
Animals were sacrificed after treatments and brains were collected for dissections of the cerebral
cortex, hypothalamus and pons. Samples were analyzed for PTM on the histones H3K4Me3,
H3K9ac, H3K9Me2, H3K27Me3, and H3K36Me2 levels by Western blot procedure.

Results:
CBD increased the PTM levels on the histones H3K4Me3, H3K9ac, and H3K27Me3 in
the cerebral cortex whereas no significant differences were found in H3K9Me2 and H3K36Me2. In
addition, in the hypothalamus, CBD decreased the contents of H3K9ac while no significant effects
were observed in H3K4Me3, H3K9Me2, H3K27Me3, and H3K36Me2. Lastly, in the pons, CBD-
treated rats showed a significant decline on the PTM levels of H3K4Me3 whereas no statistical
differences were found in H3K9ac, H3K9Me2, H3K27Me3, and H3K36Me2.

Conclusion:
The study showed that CBD induced differential effects in levels of PTM on the histones
H3K4Me3, H3K9ac, H3K9Me2, H3K27Me3, and H3K36Me2 in several brain regions.
Genetic Diversity of Two Tilapia Species (Oreochromis Niloticus and Sarthrodon Galilaeus) Using Random Amplified Polymorphic DNA
Authors: Omer Omeima M. , Abdalla Abd El Wahab H. , Mahmoud Zuheir N. 
Published: September 2020

Introduction:In this study, the genetic variability in eight populations ofOreochromis niloticusand seven populations ofSarotherodon galilaeuswas estimated using molecular markers.Materials and Methods:Fish specimens were collected from eight sites representing the White Nile, Blue Nile and the River Nile. Tissue samples from gills and dorsal fin were removed from individual specimens and preserved separately in absolute ethanol prior to molecular analysis by RAPD-PCR using eight primers. DNA analysis using OPA-04, OPA-13, OPA-03, OPA-06, OPA-07, OPA-09, OPA-10 and RAPD-8 produced different bands for each.Results and Discussion:The total bands generated by the primers were: 17, 16, 18, 12, 12, 14, 14, and 17. They were in the range of 100 to 1020 bp. Levels of variability were estimated by the proportion of polymorphic bands obtained by each primer within a population. The range of variability was wider inO. niloticus(46.0 to 91.7) compared toS. galilaeus(56.2 to 83.3). The dendrogram obtained differentiated the populations into 22 sub-clusters.Oreochromis niloticusfrom Al Kalakla exhibited a high level of genetic diversity. This diversity is evident among and within the studied populations, as estimated by RAPD-PCR techniques.Conclusion:To promote tilapia production, the study recommended increasing genetic variation within broodstocks by crossing high similarity breeds with low similarity ones.
Pengembangan E-Learning Berbasis Website menggunakan Metode Waterfall
Authors: Septyanto Kukuh , Hamid Mustofa Abi , Aribowo Didik 
Published: September 2020

Perkembangan informasi, komunikasi dan teknologi yang semakin pesat telah banyak mengubah berbagai bidang kehidupan, termasuk dibidang pendidikan. Sudah semestinya sistem pembelajaran yang ada di Program Studi Pendidikan Vokasional Teknik Elektro Untirta harus lebih inovatif. Mengembangkan sistem pembelajaran e-learning berbasis website dan mengetahui kelayakan produk yang dihasilkan merupakan tujuan dari penelitian ini, dengan memakai metode Research and Development (RD) dengan model pengembangan waterfall yang terdiri dari beberapa tahapan yaitu, analisis kebutuhan, desain, implementasi atau pengkodeaan, dan pengujian. Subjek pada penelitian ini adalah 3 orang ahli produk, 3 dosen 1 staff, dan 51 mahasiswa. Maka didapatkan hasil penelitian yang telah diolah, berupa data (1) tingkat kelayakan produk website e-learning diperoleh nilai skor rata-rata sebesar 74,6 dengan kategori “sangat layak”. (2) hasil uji coba penggunaan website e-learning oleh dosen dan staff diperoleh nilai skor rata-rata sebesar 90,3 dengan kategori “sangat layak”. (3) hasil uji coba penggunaan website e-learning oleh mahasiswa diperoleh nilai skor rata-rata sebesar 85 dengan kategori “sangat layak”. Dapat ditarik kesimpulan, maka sistem pembelajaran e-learning berbasis website sangat layak. Agar pemanfaatan website e-learning terjaga, maka perlu dilakukan pemeliharaan rutin, penambahan fitur sesuai kebutuhan pengguna dan memperkuat keamanan website e-learning.
Optimalisasi Media Penyimpanan pada Sistem Inventori Stok Barang untuk PT. Multi Usaha Sejahtera Jaya menggunakan Metode Goldbach Codes
Authors: Frayudha Angga Debby , Purwanti Siti 
Published: September 2020

Pengelolaan data secara konvensional, baik manual pada buku maupun penggunaan aplikasi pengolah data (kata atau angka) dinilai masih memiliki keterbatasan terutama dalam hal keterjangkauan akses dan pengelolaan. Sistem informasi inventori mampu menyajikan pengelolaan data berupa informasi-informasi yang dibutuhkan untuk produktivitas tempat usaha sesuai karakteristik pengguna informasi pada tempat usaha tersebut. Lebih lanjut untuk proses transmisi data yang lebih baik, diperlukan optimalisasi media penyimpanan melalui teknik kompresi data tertentu. Salah satu algoritma kompresi data teks yang memiliki keunggulan pada optimalisasi ukuran hasil kompresi adalah Goldbach Codes. Artikel ini mendeskripsikan pengembangan sistem pengelolaan inventori dengan kemampuan dapat menyimpan maupun mengubah data stok barang, penjualan, pembelian barang dan laporannya yang memiliki efisiensi data yang optimal. Dalam penelitian ini menggunakan metode Riset and Development dengan 7 tahapan berupa: 1) potensi masalah, 2) pengumpulan data, 3) desain produk, 4) validasi desain, 5) uji coba produk, 6) revisi produk, 7) uji coba pemakaian. Hasil dari pengujian aplikasi mendapatkan presentase kelayakan sebesar 83% dari ahli media (IT), 85% dari pengguna skala kecil (PT Multi Usaha Sejahtera). Dapat disimpulkan bahwa media yang dikembangkan “sangat layak”. Kelebihan dari sistem yang diusulkan adalah pencarian data semakin cepat dan paperless. Penelitian ini dapat dijadikan pijakan untuk penelitian terkait. Aspek yang perlu dipertimbangkan pada penelitian ke depan adalah aspek keberterimaan sistem informasi
Clinical Predictive Models for COVID-19: Systematic Study
Authors: Schwab Patrick , DuMont Schütte August , Dietz Benedikt , Bauer Stefan 
Published: September 2020

Background
COVID-19 is a rapidly emerging respiratory disease caused by SARS-CoV-2. Due to the rapid human-to-human transmission of SARS-CoV-2, many health care systems are at risk of exceeding their health care capacities, in particular in terms of SARS-CoV-2 tests, hospital and intensive care unit (ICU) beds, and mechanical ventilators. Predictive algorithms could potentially ease the strain on health care systems by identifying those who are most likely to receive a positive SARS-CoV-2 test, be hospitalized, or admitted to the ICU.

Objective
The aim of this study is to develop, study, and evaluate clinical predictive models that estimate, using machine learning and based on routinely collected clinical data, which patients are likely to receive a positive SARS-CoV-2 test or require hospitalization or intensive care.

Methods
Using a systematic approach to model development and optimization, we trained and compared various types of machine learning models, including logistic regression, neural networks, support vector machines, random forests, and gradient boosting. To evaluate the developed models, we performed a retrospective evaluation on demographic, clinical, and blood analysis data from a cohort of 5644 patients. In addition, we determined which clinical features were predictive to what degree for each of the aforementioned clinical tasks using causal explanations.

Results
Our experimental results indicate that our predictive models identified patients that test positive for SARS-CoV-2 a priori at a sensitivity of 75% (95% CI 67%-81%) and a specificity of 49% (95% CI 46%-51%), patients who are SARS-CoV-2 positive that require hospitalization with 0.92 area under the receiver operator characteristic curve (AUC; 95% CI 0.81-0.98), and patients who are SARS-CoV-2 positive that require critical care with 0.98 AUC (95% CI 0.95-1.00).

Conclusions
Our results indicate that predictive models trained on routinely collected clinical data could be used to predict clinical pathways for COVID-19 and, therefore, help inform care and prioritize resources.
ACEITES ESENCIALES DE EUCALYPTUS GLOBULUS (LABILL) Y BURSERA GRAVEOLENS (KUNTH) TRIANA & PLANCH PARA EL CONTROL DE MOSQUITOS DE IMPORTANCIA MÉDICA
Authors: Leyva Maureen , Del Carmen Marquetti María , Montada Domingo , Payroll Juan , Scull Ramón , Morejón Gisel , Pino Oriela 
Published: September 2020

El extensivo uso de los insecticidas ha provocado daños medioambientales de diversos tipos y generado resistencia en el sitio diana de control de algunos vectores. El estudio de la actividad insecticida de plantas, constituye un objetivo primordial en la búsqueda de fuente de compuestos bioplaguicidas para la preparación de formulados. El objetivo propuesto para este trabajo consistió en; evaluar la actividad bioplaguicida de los aceites esenciales de <em>Eucalyptus globulus </em>(Labill, 1800<em>) </em>y<em> Bursera graveolens </em>((Kunth) Triana &amp; Planch, 1872)<em> </em>sobre <em>Aedes aegypti</em> (Linnaeus, 1762),<em> Aedes albopictus </em>(Skuse<em>, </em>1894) <em>y Culex quinquefasciatus</em><em> </em>(Say, 1823)<em>. </em>Se evaluó la actividad larvicida siguiendo la metodología estandarizada de la Organización Mundial de la Salud (OMS) y en el caso de la actividad adulticida se utilizó la metodología de impregnación de papeles según OMS y la impregnación de botellas según lo establecido por el Centro para el Control de Enfermedades (CDC). Los aceites evaluados evidenciaron una significativa actividad larvicida en las poblaciones de mosquitos estudiadas con valores de concentraciones letales medias calculadas inferiores a 100 mg·L<sup>-1</sup>. Las concentraciones estudiadas sobre la fase adulta que favorecieron el 100 % de derribo de los individuos expuestos a los 30 min oscilaron entre 10 y 60 mg·mL<sup>-1</sup>. Los resultados obtenidos con<em> B. graveolens</em> son los primeros reportes de esta actividad, para la región de las Américas. Estos resultados evidenciaron que los aceites esenciales de estos recursos forestales pueden ser considerados candidatos promisorios para el control de mosquitos de importancia médica.
New distributional records of Cleome chelidonii L.f. and Cleome rutidosperma DC. (Cleomaceae) in Madura Island
Authors: Irsyam Arifin Surya Dwipa , Hariri Muhammad Rifqi , Setiawan Ashari Bagus , Irwanto Rina Ratnasih , Dewi Asih Perwita 
Published: September 2020

Calcareous soil and dry climate are characteristic of Madura Island, located on the east coast of Java, Indonesia. The group of flowering plants that adapted to these conditions is the genus Cleome L. (Cleomaceae). In 1963, Backer and Bakhuizen van den Brink Jr. only listed three species of Cleome from Madura, i.e., C. aspera J.König ex DC., C. gynandra L., and C. viscosa L. Since then, the updated data on the genus Cleome of Madura is not provided yet. Therefore, this study aimed to provide updated information on the genus in Madura island. The botanical exploration was conducted at Bangkalan, Sampang, Pamekasan, and Sumenep in December 2019 to January 2020. The two additional species, namely C. chelidonii L.f. and C. rutidosperma DC., were reported for the first time in Madura. Both species were considered as the newly distributional record for the island. Cleome chelidonii was found in Gapura Tengah (Sumenep Regency), and C. rutidosperma was collected from Kamal (Bangkalan Regency). The botanical information on both species is presented, including the updated key to the Cleome of Madura Island. This study provides updated information on genus Cleome in Madura and reporting the existence of Cleome chelidonii and Clome rutidosperma from the island. The presence of both species was considered as a newly distributional record.
Charity: The Divine Science of Allah (SWT)
Authors: Dadach Zin Eddine 
Published: September 2020

The purpose of this instigation is an attempt to perceive the divine science in nature based on some Quranic verses and a spiritual interpretation of movements in nature. First, based on the Quranic verse (55:7), it is understood that Allah (SWT) urges the regions rich in energy to give part of this richness to the areas poor in energy to create balance and harmony in nature. This is described in this investigation as the first divine law of charity of the Divine Science. From the second Quranic verse (15:21), which is described as the second divine law of charity of the Divine Science, Allah (SWT) also fixes the amount of the matter or energy to be flowing from a rich region to a poor region. Using the water cycle as an example to sense the divine science, it is perceived that the divine purpose of the oceans is to use solar energy in order to generate a particular flow of water vapor, predetermined by Allah (SWT), as the charity to the dry skies over the seas and oceans. Moreover, the divine duty of the skies over the seas and oceans is to utilize the power of the wind to offer a certain part of that flow of water, predesignated by Allah (SWT), as the charity to the dry skies over the lands. Finally, the divine purpose of the skies over lands is to use the earth’s gravity in order to offer a portion of water as rain or snow, predestined by Allah (SWT), as the charity to the dry land.
IMPLEMENTASI MANAJEMEN PESERTA DIDIK PADA SATUAN PAUD
Authors: Agusriani Ade , Hading Hading , Wahdaniah Hilda Ayu , Syarif Siti Hardiyanti , Amalia Dila Rizki , A. Arsyad Nur Ismi 
Published: September 2020

Penelitian ini bertujuan untuk mengetahui gambaran implementasi manajemen peserta didik di TK Pertiwi Malaka Jl. Massusungan DG Matutu Desa Malaka, Kec. Tondong Tallasa, Kab. Pangkep. Jenis penelitian yang di lakukan adalah penelitian deskriptif kualitatif dengan objek penelitian adalah seorang guru TK Pertiwi Malaka dengan teknik pengumpulan datamelalui observasi dan wawancara. Hasil penelitian menunjukkan bahwa TK Pertiwi Malaka telah memenuhi standar dalam manajemen peserta didik yaitu: a) Tahapan pertama perencanaan peserta didik dengan melakukan analisis kebutuhan peserta didik dengan mempertimbangkan rasio jumlah ruang kelas, jumlah guru dan murid. b) Kehadiran dan ketidak hadiran peserta didik disebut dengan istilah absensi disekolah. c) Pencatatan dan pelaporan peserta didik dapat dimulai dari anak masuk sekolah sampai anak lulus/tamat sekolah. d) Pelaksanaan tata tertib peserta didik yaitu pakaian seragam sekolah sudah menjadi kewajiban bagi setiap peserta didik. e) Evaluasi kegiatan peserta didik dilakukan melalui beberapa cara yakni observasi, wawancara dan portofolio. f) Pembiayaan peserta didik. g) Kelulusan dan alumni peserta didik di buktikan dengan pemberian ijazah saat lulus.
Evaluasi Penyaluran Dana Ekonomi Bergulir Untuk Memberdayakan Masyarakat di Kelurahan Padangmatinggi
Authors: Hasibuan Nurharisyah 
Published: September 2020

Distribution of revolving economic funds is carried out by means of savings and loans, which are given directly to the poor for business development. The results showed that the distribution of economic funds revolving in Padangmatinggi village was carried out by various selections by the BKM team and grouping all poor people who received revolving economic funds. Meanwhile, the evaluation of revolving economic fund distribution in the Padangmatinggi village is said to be not going well. This condition is seen from the four performance indicators of the PNPM team (survey, distribution, supervision and evaluation), some are not working well, namely supervision. This is evidenced by the existence of people who still have not paid the revolving economic fund loans in the Padangmatinggi village.Keywords: Empowerment, Revolving Fund AbstrakPenyaluran dana ekonomi bergulir dilakukan dengan cara simpan pinjam, yang diberikan langsung kepada masyarakat miskin untuk pengembangan usaha. Hasil penelitian menunjukkan bahwa penyaluran dana ekonomi bergulir di kelurahan Padangmatinggi dilakukan dengan berbagai seleksi oleh tim BKM dan mengelompokkan semua masyarakat miskin yang menerima bantuan dana ekonomi bergulir. Sementara itu, evaluasi penyaluran dana ekonomi bergulir di kelurahan Padangmatinggi dikatakan kurang berjalan dengan baik. Kondisi itu dilihat dari empat indikator kinerja tim PNPM (survei, penyaluran, pengawasan dan evaluasi), ada yang tidak berjalan dengan baik yaitu tentang pengawasan. Hal ini dibuktikan dengan adanya masyarakat yang masih belum membayar pinjaman dana ekonomi bergulir di kelurahan Padangmatinggi.Kata Kunci : Pemberdayaan, Dana Bergulir
PEMBERDAYAAN MASYARAKAT MELALUI PEMBINAAN KELOMPOK PERIKANAN DALAM MENINGKATKAN KESEJAHTERAAN MASYARAKAT
Authors: Iswadi Iswadi 
Published: September 2020

AbstrakPenelitian ini bertujuan untuk: (1) mengetahui pelaksanaan pemberdayaan, (2) faktor pendukung dan penghambat pemberdayaan, penelitian ini menggunakan pendekatan deskriptif kualitatif. Subjek penelitian adalah: kelompok pembudidaya ikan 'mandiri saiyo', anggota kelompok dan tokoh masyarakat. Pengumpulan data melalui: wawancara, observasi, dan dokumentasi. Dalam analisis data dilakukan melalui tahapan reduksi data, penyajian data, dan penarikan kesimpulan. Uji validitas data penelitian dengan menggunakan triangulasi sumber. Hasil penelitian mengungkapkan pelaksanaan pemberdayaan masyarakat dilakukan melalui kelompok pembudidaya ikan 'Mandiri Saiyo' yaitu: mengubah pola pikir masyarakat terhadap budidaya ikan, memberikan pengetahuan tentang budidaya ikan yang baik dan benar serta memberikan keterampilan terkait dengan pembuatan pakan, faktor pendukung yaitu: dukungan dari warga, pemerintah, antusias masyarakat dan lokasi yang strategis, sementara faktor penghambat adalah: kurangnya manajemen organisasi, kurangnya kesadaran anggota kelompok, kurangnya kerja tim dan pemasaran hasil panen, hasil pelaksanaan pemberdayaan meningkatnya stimulus masyarakat untuk menggunakan lahan mereka untuk budidaya ikan, lapangan kerja meningkat dan mengurangi pengangguran, meningkatkan pendapatan anggota, meningkatkan pengetahuan tentang budidaya ikan dan meningkatkan kemampuan untuk membuat pakan. Kata Kunci: Pemberdayaan, Pembudidaya IkanAbstract.This study aims to: (1) determine the implementation of empowerment, (2) supporting and inhibiting factors of empowerment, this study uses a qualitative descriptive approach. The research subjects are: 'saiyo independent' fish cultivator groups, group members and community leaders. Data collection through: interviews, observation, and documentation. In the data analysis is done through the stages of data reduction, data presentation, and drawing conclusions. Test the validity of research data by using source triangulation. The results of the study revealed (the implementation of community empowerment is done through the group of fish farmers 'Mandiri Saiyo' namely: changing the mindset of the community towards the benefits of fish farming, providing knowledge about good and right fish culture and providing skills related to making food, supporting factors namely: support from residents, government, community enthusiasm and supportive locations, while inhibiting factors are: lack of organizational management, lack of awareness of group members, lack of teamwork and marketing of yields, implementation results of increased community stimulus to use their land for fish farming, field employment and reduced unemployment, increased member income, increased knowledge about fish farming and increased ability to make feed.Keywords: Empowerment, fish cultivator
Pituitary macroadenoma apoplexy in a severe acute respiratory syndrome-coronavirus-2-positive testing: Causal or casual?
Authors: Solorio-Pineda Saúl , Almendárez-Sánchez César Adán , Tafur-Grandett Abrahan Alfonso , Ramos-Martínez Gabriel Arturo , Huato-Reyes Raúl , Ruiz-Flores Milton Inocencio , Sosa-Najera Antonio 
Published: September 2020

Background:
In December 2019, in Wuhan, a new virus emerged, causing severe acute respiratory syndrome (SARS) secondary to infection by a type of coronavirus, causing coronavirus disease (COVID-19). The pandemic caused by the new coronavirus has had implications in the central nervous system. COVID-19 is known to be characterized by coagulation activation and endothelial dysfunction, causing ischemic and hemorrhagic vascular syndromes.

Case Description:
A 27-year-old male patient case with progressive decrease in visual acuity, associated with respiratory symptoms and intense headache. Multilobar infiltrate with a reticulonodular pattern is evident on chest CT scan. Brain CT scan with pituitary macroadenoma apoplexy was shown. SARS-Cov2 was confirmed, and respiratory support initiated. However, the patient died shortly afterward, secondary to pulmonary complications.

Conclusion:
The angiotensin-converting enzyme (ACE) II receptor is expressed in circumventricular organs and in cerebrovascular endothelial cells, which play a role in vascular autoregulation and cerebral blood flow. For this reason, is rational the hypothesize that brain ACE II could be involved in COVID-19 infection. Underlying mechanisms require further elucidation in the future.