bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new approach to curvature measures in linear shell theories
Authors: Šilhavý Miroslav 
Published: December 2020

The paper presents a coordinate-free analysis of deformation measures for shells modeled as 2D surfaces. These measures are represented by second-order tensors. As is well-known, two types are needed in general: the surface strain measure (deformations in tangential directions), and the bending strain measure (warping). Our approach first determines the 3D strain tensor E of a shear deformation of a 3D shell-like body and then linearizes E in two smallness parameters: the displacement and the distance of a point from the middle surface. The linearized expression is an affine function of the signed distance from the middle surface: the absolute term is the surface strain measure and the coefficient of the linear term is the bending strain measure. The main result of the paper determines these two tensors explicitly for general shear deformations and for the subcase of Kirchhoff-Love deformations. The derived surface strain measures are the classical ones: Naghdi’s surface strain measure generally and its well-known particular case for the Kirchhoff-Love deformations. With the bending strain measures comes a surprise: they are different from the traditional ones. For shear deformations our analysis provides a new tensor [Formula: see text], which is different from the widely used Naghdi’s bending strain tensor [Formula: see text]. In the particular case of Kirchhoff–Love deformations, the tensor [Formula: see text] reduces to a tensor [Formula: see text] introduced earlier by Anicic and Léger (Formulation bidimensionnelle exacte du modéle de coque 3D de Kirchhoff–Love. C R Acad Sci Paris I 1999; 329: 741–746). Again, [Formula: see text] is different from Koiter’s bending strain tensor [Formula: see text] (frequently used in this context). AMS 2010 classification: 74B99
The efficacy of dexamethasone implants following anti-VEGF failure for macular oedema in retinal vein occlusion
Authors: Yap Timothy E , Husein Salman , Miralles de Imperial-Ollero Juan Antonio , Colizzi Benedetta , Cordeiro Maria Francesca , Younis Saad 
Published: December 2020

Purpose: To investigate the efficacy of intravitreal dexamethasone implants (DEX) after anti-VEGF failure in retinal vein occlusion macular oedema. Methods: Retrospective cohort study of DEX implant (0.7 mg) given after anti-VEGF ‘failure’. Switch to DEX occurred if a ⩽ +5 ETDRS letter gain and ⩽20% reduction in central subfield thickness was present following ⩾6 consecutive anti-VEGF injections. The primary endpoint was VA change 30 days after DEX. Secondary outcomes were peak VA change, VA change at monthly timepoints, percentage achieving 15-letter gain, central subfield thickness (CST) and intraocular pressure (IOP). Results: Sixty-two injections in 62 patients associated with 26% central retinal vein occlusion (CRVO) and 74% branch retinal vein occlusion (BRVO) were eligible. There was a modest, significant improvement in mean VA change at 30 days compared to baseline (+6 letters, 95% CI +2.2 to +9.1 letters, p < 0.01). DEX implant significantly improved mean peak VA change compared to preceding anti-VEGF by +18.1 letters in CRVO ( p = 0.002) and +13.2 letters in BRVO ( p < 0.0001). IOP peaked between 30 and 60 days following injection, with 31% of CRVO and 11% of BRVO patients experiencing an IOP ⩾ 25 mmHg. Conclusion: DEX implant provides useful rescue therapy in cases of anti-VEGF ‘failure’ for macular oedema following retinal vein occlusion, resulting in improved functional outcomes at 30 days.
Prediction of Prognostic Biomarkers and Construction of an Autophagy Prognostic Model for Colorectal Cancer Using Bioinformatics
Authors: Liu Ting-ting , Liu Shu-min 
Published: December 2020

Objective: The incidence of colorectal cancer is increasing every year, and autophagy may be related closely to the pathogenesis of colorectal cancer. Autophagy is a natural catabolic mechanism that allows the degradation of cellular components in eukaryotic cells. However, autophagy plays a dual role in tumorigenesis. It not only promotes normal cell survival and tumor growth but also induces cell death and suppresses tumors survival. In addition, the pathogenesis of various conditions, including inflammation, neurodegenerative diseases, or tumors, is associated with abnormal autophagy. The present work aimed to examine the significance of autophagy-related genes (ARGs) in prognosis prediction, to construct an autophagy prognostic model, and to identify independent prognostic factors for colorectal cancer (CRC). Methods: This study discovered a total of 36 ARGs in CRC cases using The Cancer Genome Atlas (TCGA) and Human Autophagy-dedicated (HADd) databases along with functional enrichment analysis. Then, an autophagy prognostic model was constructed using univariate Cox regression analysis, and the key prognostic genes were screened. Finally, independent prognostic markers were determined through independent prognostic analysis and clinical correlation analysis of key genes. Results: Of the 36 differentially expressed ARGs, 13 were related to prognosis, as determined by univariate Cox regression analysis. A total of 6 key genes were obtained by a multivariate Cox regression analysis. Independent prognostic values were shown by 3 genes, namely, microtubule-associated protein 1 light chain 3 (MAP1LC3C), small GTPase superfamily and Rab family (RAB7A), and WD-repeat domain phosphoinositide-interacting protein 2 (WIPI2) by independent prognostic analysis and clinical correlation. Conclusions: In this study, molecular bioinformatics technology was employed to determine and construct a prognostic model of autophagy for colon cancer patients, which revealed 3 autophagy-related features, namely, MAP1LC3C, WIPI2, and RAB7A.
Peripheral EphrinB1/EphB1 signalling attenuates muscle hyperalgesia in MPS patients and a rat model of taut band-associated persistent muscle pain
Authors: Jin Feihong , Zhao Lianying , Hu Qiya , Qi Feng 
Published: December 2020

Background Myofascial pain syndrome (MPS) is an important clinical condition that is characterized by chronic muscle pain and a myofascial trigger point (MTrP) located in a taut band (TB). Previous studies showed that EphrinB1 was involved in the regulation of pathological pain via EphB1 signalling, but whether EphrinB1-EphB1 plays a role in MTrP is not clear. Methods The present study analysed the levels of p-EphB1/p-EphB2/p-EphB3 in biopsies of MTrPs in the trapezius muscle of 11 MPS patients and seven healthy controls using a protein microarray kit. EphrinB1-Fc was injected intramuscularly to detect EphrinB1s/EphB1s signalling in peripheral sensitization. We applied a blunt strike to the left gastrocnemius muscles (GM) and eccentric exercise for 8 weeks with 4 weeks of recovery to analyse the function of EphrinB1/EphB1 in the muscle pain model. Results P-EphB1, p-EphB2, and p-EphB3 expression was highly increased in human muscles with MTrPs compared to healthy muscle. EphB1 (r = 0.723, n = 11, P < 0.05), EphB2 (r = 0.610, n = 11, P < 0.05), and EphB3 levels (r = 0.670, n = 11, P < 0.05) in the MPS group were significantly correlated with the numerical rating scale (NRS) in the MTrPs. Intramuscular injection of EphrinB1-Fc produces hyperalgesia, which can be partially prevented by pre-treatment with EphB1-Fc. The p-EphB1 contents in MTrPs of MPS animals were significantly higher than that among control animals (P < 0.01). Intramuscular administration of the EphB1 inhibitor EphB1-Fr significantly suppressed mechanical hyperalgesia. Conclusions The present study showed that the increased expression of p-EphB1/p-EphB2/p-EphB3 was related to MTrPs in patients with MPS. This report is the first study to examine the function of EphrinB1-EphB1 signalling in primary muscle afferent neurons in MPS patients and a rat animal model. This pathway may be one of the most important and promising targets for MPS.
The patient with cirrhosis in the intensive care unit and the management of acute-on-chronic liver failure
Authors: Passi Neha N , McPhail Mark JW 
Published: December 2020

Acute on chronic liver failure (ACLF) is a clinical syndrome characterised by acute hepatic decompensation, multi-organ failure and high mortality, in patients with cirrhosis.  Organ dysfunction in ACLF is often reversible and when necessary these patients should be considered appropriate candidates for admission to an intensive care unit (ICU). The yearly increase in numbers of patients with ACLF admitted to ICU has been matched with an improvement in survival.  ACLF has only been recently defined. In the absence of evidence-based guidelines we outline a systems-based approach to care which encompasses accepted ICU practice and evidence from trials in this cohort. We advocate for timely referral to specialist liver centres and consider the complexities of proceeding with liver transplantation. Equally, in a proportion of patients who continue to deteriorate, appropriate ceilings of care should be established.  Future clinical trials may change treatment paradigms but care of patients with ACLF is undoubtedly becoming an integral part of an intensivist’s practice. We hope that this review is a welcome starting point when managing this complex clinical syndrome.
Clinical outcomes, predictors of prognosis and health economics consequences in IBD patients after discontinuation of the first biological therapy
Authors: Shivaji Uday N. , Bazarova Alina , Critchlow Tamsin , Smith Samuel C. L. , Nardone Olga Maria , Love Melanie , Davis Joanne , Ghosh Subrata , Iacucci Marietta 
Published: December 2020

Background: In real-world clinical practice, biologics in inflammatory bowel diseases (IBD) may be discontinued for a variety of reasons, including discontinuation initiated by gastroenterologists. The aims of the study are to report outcomes after discontinuation and predictors of prognosis after a minimum follow-up of 24 months; outcomes of gastroenterologist-initiated discontinuation with resulting direct cost implications on the health system were also studied. Methods: IBD patients who discontinued their first-use biologics between January 2013 and December 2016 were identified at our tertiary centre. Reasons for discontinuation and pre-defined adverse outcomes (AO) were recorded. Data were analysed using univariable and multivariable logistic regressions within a machine learning technique to predict AO. Gastroenterologist-initiated discontinuations were analysed separately, and Kaplan–Meier survival analysis performed; direct costs of AO due to discontinuation were assessed. Results: A total of 147 patients discontinued biologics (M = 74; median age 39 years; Crohn’s Disease = 110) with median follow-up of 40 months (range 24–60 months). In the total cohort, there were fewer AO among gastroenterologist-initiated discontinuations compared with patient-initiated; 54% (of the total group) had AO within 6 months. Among 59 gastroenterologist-initiated discontinuations, 23 (40%) had IBD-related AO within 6 months and 53 (90%) patients had AO by end of follow-up. Some 44 (75%) patients needed to restart biologics during follow-up, and direct costs due to AO and restart of biologics were high. Conclusions: The proportion of patients who have AO following discontinuation of biologics is high; clinicians need to carefully consider predictors of poor prognosis and high relapse rates when discussing discontinuation. The direct costs of managing AO probably offset theoretical economic gains, especially in the era where cost of biologics is reducing. Biologics should probably be continued without interruptions in most patients who have achieved remission for the duration these remain effective and safe.
User Assessment of a Novel Suspension for a Wheelchair—A Prospective, Randomized, Double Blind Trial
Authors: Giwnewer Uriel , Rubin Guy , Friedman Alex , Rozen Nimrod 
Published: December 2020

Background: Many Wheelchair users experience adverse effects specific to their situation, some of which might be avoided if suspension systems are integrated into the wheelchair. Objectives: Our study aimed to compare the user experience using a novel wheelchair suspension system with normal wheels. We tried to quantify the user feelings and impressions while using the different wheels. Study Design: Double blinded comparative randomized study. Methods: The patients were randomized into 2 groups. One used shock absorbing wheels, and the other group had a set of standard wheels with the same exact wheelchairs. The patients were taken to a daily trip by the caregivers and given questionnaires in the second and fourth days. On the morning of the third day the wheels were interchanged, creating a cross over between the groups. We collected general and medical information from the participants. The main outcome measures were the questionnaires filled by the patients and the caregivers aiming to quantify the user experience with the suspension equipped wheels. Results: Statistical significance was reached in 2 questions referred to the patients: “In general—During the ride I didn’t feel the bumps” and “I feel very confident when riding the chair” and in one question referred to the caregiver—“It was easy to push the chair in suboptimal ground.” Conclusions: We conclude that the shock absorbing system provided a better user experience in the immediate term than standard wheels. Further study is needed to assess the long-term implications.
Who Is the Agent of Change?
Authors: Nishikawa Ken 
Published: December 2020

The benefits of working in a large company are better infrastructure, well-defined policies, training and learning opportunities, job security and gradual growth. Slow decision-making due to the bureaucratic structure is a major drawback. The unique character of small firms offers agile structure, quick response, family-like atmosphere, opportunity to wear many hats as advantages, and lower compensation and restricted growth as disincentives to joining. However, if employees get their human relationships to energize, the size of the firm will be inconsequential for their success. That is, small firms can only offer a congenial atmosphere as a big firm never. Therefore, understanding what gives us energy and how we utilize it is critical for the leaders in small firms. This case study focuses on the CEO of a small family-owned firm (Nishio Glass and Mirror) whose decision to usher in positive organizational scholarship with the help of consultants set the firm on a successful journey. Even though statistics show that most change efforts fail irrespective of the size of the firm, in this case, it succeeded. This case study informs us that workplaces can be a community for people to amplify positive energy unleashing virtuous circles of growth. Research Questions: What is positive organizational scholarship? How can it be implemented in a small firm? Theory: Positive organizational scholarship and agents of change. Type of the Case: Study of a phenomenon. Basis of the Case: Phenomenon. Protagonist: Present, the CEO of the firm. Findings for Phenomenon-based Research Case An organization is not a machine to transform resources into material properties. It is a community where people share the agentic roles with one another to let them transform. In a trustful community, people can examine the experience of ‘pregnant void’ to open a virtuous mindset; moreover, people can give suffering for others as an agent to embody the meaning of virtues. Discussions for Phenomenon-based Research Case To manage a chaotic situation, which approach should be applied: crisis management or a proper management system? In this case, even a management system failed and dumped the CEO in psychological chaos. Which is that process that an external OD consultant can adopt to transform an organization by setting its employees on the path of self-transformation? If we apply hedonic happiness to the case, it seems to be fit for the past situation where people in the case wanted to have materialistic and short-term success. Discuss the alternative that can be applied.
Equity and Sustainability: An Exposition
Authors: Bhattacharya Rabi , Majumdar Mukul 
Published: December 2020

The paper is an exposition of some issues involving sustainability of equitable (stationary) plans in infinite horizon models. We consider examples of deterministic as well as stochastic models. The models provide conditions on the possibility, inevitability or probability of extinction or collapse. JEL Classifications: D8, Q2, Q3
Does a company’s origin matter in moral judgment?
Authors: Dib-Slamani Hind , Grolleau Gilles , Mzoughi Naoufel 
Published: December 2020

We blend the institutional and social identity theories to explain why foreign companies may endure a differentiated treatment compared to domestic ones. We extend the “liability of foreignness” (LOF) reasoning to the moral domain. Using a survey experiment in Algeria and France, we examine whether observers judge similarly or differently the same ethical and unethical practices by manipulating the doers’ origin. Each treatment corresponds to a specific combination of company behavior (ethical vs. unethical) and company origin (no origin mentioned vs. domestic origin vs. foreign origin). We found that company origin matters for the ethical and some unethical scenarios. However, the foreignness consequences in the moral domain are not always consistent with a simplistic application of LOF-based arguments, leading us to consider a more complex picture than initially expected. In the Algerian sample, we found that foreign companies can even benefit from an advantage compared to domestic ones. JEL CLASSIFICATION F23; C91
Fostering task and adaptive performance through employee well-being: The role of servant leadership
Authors: Kaltiainen Janne , Hakanen Jari 
Published: December 2020

In this study, we provide insights on how servant leadership may promote employee performance. We investigate whether the associations between increases in servant leadership and employees’ task and adaptive performance are mediated by changes in the two antipodes of employee well-being: work engagement and burnout. We utilized a two-wave survey data ( N = 2453) collected from 34 organizations and latent change score modeling as an analytical approach to examine associations among within-person changes. Our findings showed that increased perceptions of servant leadership were associated with increases in work engagement and decreases in burnout. Increases in work engagement were associated with increases in task performance and four subfacets of adaptive performance (i.e., stress management, reactivity, creativity, and interpersonal adaptivity). Decreases in burnout were associated with increases in task performance. Our findings suggest that improved servant leadership practices may foster employees’ task and adaptive performance especially through the promotion of work engagement. JEL CLASSIFICATION: L200 Firm Objectives, Organization, Behavior: General
Comparison between hyaluronic acid filler and botulinum toxin type A in the treatment of thyroid upper eyelid retraction
Authors: Hassan Hussien Mahaa , Abd El-Wahed Hassan Elham , El-Haddad Nermien Salah El-Dien Mohammed 
Published: December 2020

Purpose: The aim of this study was to compare between hyaluronic acid filler (HA) and botulinum toxin type A (BTX-A) in the treatment of thyroid upper eyelid retraction. Study design: This was a prospective comparative study. Methods: A total of 50 eyes with upper thyroid eyelid retraction were divided into 2 groups. Each group included 25 eyes, (a) hyaluronic acid filler (HA) group: received subconjunctival HA injection and (b) botulinum toxin (BTX-A) group: received subconjunctival botulinum toxin type A injection. Full ophthalmic examination and thyroid profile were done. Marginal reflex distance 1 (MRD1) and total palpebral fissure height (TPFH) were measured before and after injection weekly for 6 months. Results: There is no significant difference between the two groups regarding MRD1 till the 10th week of follow up, then it became significant from the 11th to 15th week with better results in HA filler group, then the difference between the two groups become highly significant from the 16th week afterward with better results for the HA filler over the BTX-A. With regard to TPFH, there were significant differences between the BTX-A group and the HA group with a better result in BTX-A group in the first 8 weeks. Then the difference became insignificant till the 18th week. Then the difference became significant from the 19th till the 24th week with a better result in HA group. Conclusion: HA filler has better result in treating thyroid upper eyelid retraction than BTX-A due to its predictable controllable effect, also, due to the longer duration of action and fewer side effects.
Effect of Marriage on Pre-existing Psychoses: A Convenient or Futile Solution for Severe Mental Disorders?
Authors: Behere Prakash B. , Behere Aniruddh P. , Chowdhury Debolina , Nagdive Amit B. , Yadav Richa 
Published: December 2020

Marriage can be defined as the state of being united as spouses in a consensual and contractual relationship recognized by law. The general population generally believes marriage to be a solution to mental illnesses. It can be agreed that mental disorders and marital issues have some relation. Parents of patients with psychoses expect that marriage is the solution to the illness and often approach doctors and seek validation about the success of the marriage of their mentally ill child, which is a guarantee no doctor can give in even normal circumstances. Evidence on sexual functioning in patients of psychosis is limited and needs further understanding. Studies show about 60%–70% women of the schizophrenia spectrum and illness to experience sexual difficulties. Based on available information, sexual dysfunction in population with psychosis can be attributed to a variety of psychosocial factors, ranging from the psychotic symptoms in itself to social stigma and institutionalization and also due to the antipsychotic treatment. Despite the decline in sexual activity and quality of life in general, it is very rarely addressed by both the treating doctor and by the patient themselves hence creating a lacuna in the patient’s care and availability of information regarding the illness’ pathophysiology. Patients become noncompliant with medications due to this undesirable effect and hence it requires to be given more attention during treatment. It was also found that paranoid type of schizophrenia patient had lower chances of separation than patients with other types of schizophrenia. The risk of relapse in cases with later age of onset of the disease, lower education, a positive family history of psychosis or a lower income increased more than other populations.
The influence of the corporate social responsibility disclosures on consumer brand attitudes under the impact of COVID-19
Authors: Liu Fengjun , Meng Lu , Zhao Yijun , Duan Shen 
Published: December 2020

AbstractThis study focuses on the use of we-media by small- and medium-sized enterprises (SMEs) to disclose internal corporate social responsibility (ICSR) under the impact of the 2019 novel coronavirus disease (COVID-19). Study 1 interprets the catalyst effect of COVID-19 on the externalization of SMEs’ ICSR. The fuzzy grading evaluation method is initially verified. Under the impact of COVID-19, SMEs fulfilling their ICSR can enhance consumer brand attitudes. Study 2 uses a structural equation model and empirical analysis of 946 effective samples and finds that consumers perceive the self-sacrifice of corporations during the coronavirus disease period. SMEs can fulfill their ICSR to enhance the internal explanation mechanism of consumer brand attitudes and the moderating role of enterprise losses.