bluuebunny/crossref_metadata_2025_split huggingface dataset:
Working on and with Relationships: Relational Work and Spatial Understandings of Good Care in Community Mental Healthcare in Trieste
Authors: Muusse Christien , Kroon Hans , Mulder Cornelis L. , Pols Jeannette 
Published: April 2020

AbstractDeinstitutionalization is often described as an organizational shift of moving care from the psychiatric hospital towards the community. This paper analyses deinstitutionalization as a daily care practice by adopting an empirical ethics approach instead. Deinstitutionalization of mental healthcare is seen as an important way of improving the quality of lives of people suffering from severe mental illness. But how is this done in practice and which different goods are strived for by those involved? We examine these questions by giving an ethnographic description of community mental health care in Trieste, a city that underwent a radical process of deinstitutionalization in the 1970s. We show that paying attention to the spatial metaphors used in daily care direct us to different notions of good care in which relationships are central. Addressing the question of how daily care practices of mental healthcare outside the hospital may be constituted and the importance of spatial metaphors used may inform other practices that want to shape community mental health care.
The explanation game: a formal framework for interpretable machine learning
Authors: Watson David S. , Floridi Luciano 
Published: April 2020

AbstractWe propose a formal framework for interpretable machine learning. Combining elements from statistical learning, causal interventionism, and decision theory, we design an idealisedexplanation gamein which players collaborate to find the best explanation(s) for a given algorithmic prediction. Through an iterative procedure of questions and answers, the players establish a three-dimensional Pareto frontier that describes the optimal trade-offs between explanatory accuracy, simplicity, and relevance. Multiple rounds are played at different levels of abstraction, allowing the players to explore overlapping causal patterns of variable granularity and scope. We characterise the conditions under which such a game is almost surely guaranteed to converge on a (conditionally) optimal explanation surface in polynomial time, and highlight obstacles that will tend to prevent the players from advancing beyond certain explanatory thresholds. The game serves a descriptive and a normative function, establishing a conceptual space in which to analyse and compare existing proposals, as well as design new and improved solutions.
The Effect of Co-feeding Methyl Acetate on the H-ZSM5 Catalysed Methanol-to-Hydrocarbons Reaction
Authors: Zachariou A. , Hawkins A. P. , Collier P. , Howe R. F. , Parker S. F. , Lennon D. 
Published: April 2020

AbstractThe reactivity of methanol and methyl acetate mixtures over a HZSM-5 catalyst is studied over a period of 6 h at 350 °C, with small molecular weight olefins and aromatic compounds observed as reaction products. Post-reaction analysis of the catalyst shows the coke content to increase with methyl acetate content. Vibrational spectra (DRIFTS and inelastic neutron scattering, INS) indicate the major hydrocarbon species present in the coked catalysts to be methylated aromatic molecules, with INS spectra indicating a greater degree of methylation in the catalysts used with higher methyl acetate content. The greater extent of deactivation at higher methyl acetate concentrations is tentatively attributed to a diminishment of water in the zeolite cavity, which would otherwise facilitate re-generation of the active sites.
Randomised comparison of a balloon-expandable and self-expandable valve with quantitative assessment of aortic regurgitation using magnetic resonance imaging
Authors: Kooistra N. H. M. , Abawi M. , Voskuil M. , Urgel K. , Samim M. , Nijhoff F. , Nathoe H. M. , Doevendans P. A. F. M. , Chamuleau S. A. J. , Leenders G. E. H. , Leiner T. , Abrahams A. C. , van der Worp H. B. , Agostoni P. , Stella P. R. 
Published: April 2020

Abstract
Introduction
Transcatheter aortic valve implantation (TAVI) is a safe and effective treatment for inoperable, intermediate- or high-risk patients with severe symptomatic aortic stenosis and has been associated with excellent clinical outcomes. A clinically relevant remaining problem is aortic regurgitation (AR) post-TAVI, which is associated with increased mortality. Therefore, we conducted a prospective randomised trial to assess the safety and efficacy of a first-generation self-expandable valve (SEV; CoreValve) and a third-generation balloon-expandable valve (BEV; Sapien 3) with respect to clinical outcomes and AR as determined quantitatively by magnetic resonance imaging (MRI).

Methods
The ELECT study was an investigator-initiated, single-centre trial involving patients with severe symptomatic aortic stenosis and with a clinical indication for transfemoral TAVI. Fifty-six patients were randomly assigned to the BEV or SEV group.

Results
AR determined quantitatively by MRI was lower in the BEV than in the SEV group [regurgitant fraction: 1.1% (0–8.0) vs 8.7% (3.0–14.8) for SEV; p = 0.01]. Secondary endpoints according to the criteria of the Second Valve Academic Research Consortium (VARC-2) showed BEV to have better early safety [0 (0%) vs 8 (30%); p = 0.002] at 30 days and a lower risk of stroke [0 (0%) vs 5 (21%); p = 0.01], major adverse cardiac and cerebrovascular events [0 (0%) vs 10 (38%); p < 0.001] or death [0 (0%) vs 5 (19%); p = 0.02] in the 1st year compared with SEV.

Conclusions
The use of the latest generation of BEV was associated with less AR as quantitatively assessed by MRI. Although the use of MRI to quantify AR is not feasible in daily clinical practice, it should be considered as a surrogate endpoint for clinical outcomes in comparative studies of valves for TAVI.
ClinicalTrials.gov number NCT01982032.
Assessing Immediate Bed Availability and Barriers to Discharge in a United States Children’s Hospital
Authors: Burgess M. Catherine , DeLorenzo Debbie , Eriksson Carl 
Published: April 2020

ABSTRACTObjectives:The aim of this study was to quantify immediate bed availability (IBA) in a United States children’s hospital and treatment needs of hospitalized patients whose needs could be met outside a traditional hospital setting.Methods:Using a novel tool to capture census, scheduled discharges, and resource needs for hospitalized patients, we surveyed our hospital’s 5 non-neonatal inpatient pediatric units on 4 d over 1 y.Results:Median ward occupancy was 81% (range, 58-79), median intensive care unit occupancy was 80% (range, 7-19), and median IBA was 42% (range, 34-59). A median of 14 patients per day (13% of total capacity) had treatment needs that could be met by providing limited support in a nontraditional setting; the most common reason for requiring ongoing hospitalization in this group of patients was a safe discharge plan.Conclusions:Our median IBA of 42% exceeds federal recommendations, but varies widely between days surveyed. Even on days when IBA percentage is high, our total number of available beds is unlikely to meet pediatric population needs in a large-scale public health emergency.
Pricing Liquidity Risk with Heterogeneous Investment Horizons
Authors: Beber Alessandro , Driessen Joost , Neuberger Anthony , Tuijp Patrick 
Published: April 2020

AbstractWe develop an asset pricing model with stochastic transaction costs and investors with heterogeneous horizons. Depending on their horizon, investors hold different sets of assets in equilibrium. This generates segmentation and spillover effects for expected returns, where the liquidity (risk) premium of illiquid assets is determined by investor horizons and the correlation between liquid and illiquid asset returns. We estimate our model for the cross-section of U.S. stock returns and find that it generates a good fit, mainly due to a combination of a substantial expected liquidity premium and segmentation effects, while the liquidity risk premium is small.
Gonadotrophin-releasing hormone agonist triggering may improve central oocyte granularity and embryo quality
Authors: Lan Kuo-Chung , Chen Yu-Chen , Lin Yi-Chi , Tsai Yi-Ru 
Published: April 2020

SummaryThis study aimed to describe outcomes in four women aged 28–34 years with central cytoplasmic granulation (CCG) of the oocytes who underwentin vitrofertilization/intracytoplasmic sperm injection (ICSI) using gonadotrophin-releasing hormone (GnRH) agonist to replace human chorionic gonadotrophin (hCG) as a trigger of final oocyte maturation. The initial ICSI procedure showed that all four women had CCG of the ooplasm and poor quality embryos. Subsequent ICSI used an antagonist protocol with a GnRH agonist trigger replacing the agonist protocol, plus hCG triggered ovulation. Ooplasm and embryo quality were improved in all four patients. All four became pregnant and gave birth to live infants. This study provides GnRH agonist triggering that may improve ooplasm granularity and embryo quality.
Washington State Disaster Risk and Preparedness: A Primer for Health Care Providers
Authors: Morris Stephen C. 
Published: April 2020

AbstractDisaster in Washington State (USA) is inevitable. It is incumbent on health care providers to understand the practice environment as it will be affected by disasters. This means understanding the basic concepts of emergency management, local to national emergency response structure, and the risks and vulnerabilities of the region where one works. This understanding will help health care providers anticipate and prepare for disaster response and recovery. Washington State has many unique features with regard to climate and geography, population, public health, and general infrastructure that create significant vulnerabilities to disaster and strengths with regard to potential response and recovery. This report attempts to define and contextualize emergency management and to condense the extensive research and planning that has been conducted in Washington State surrounding disaster assessment, planning, mitigation, and response from a health care providerʼs prospective. The aim is to increase awareness of and preparation for disaster-related topics among health care providers by creating informed responders.
Automatic Fiber Length Measurements with a Multi-Stencil Fast Marching Method on Microscopy Images
Authors: Liu Chanjuan , Bergmeijer Menno , Pierrat Sébastien , Guise Olivier 
Published: April 2020

AbstractFiber length has a strong impact on the mechanical properties of composite materials. It is one of the most important quantitative features in characterizing microstructures for understanding the material performance. Studies conducted to determine fiber length distribution have primarily focused on sample preparation and fiber dispersion. However, the subsequent image analysis is frequently performed manually or semi-automatically, which either requires careful sample preparation or manual intervention in the image analysis and processing. In this article, an image processing and analysis method has been developed based on medial axis transformation via the multi-stencil fast marching method for fiber length measurements on acquired microscopy images. The developed method can be implemented fully automatically and without any user induced delays. This method offers high efficiency, sub-pixel accuracy, and excellent statistical representativity.
Cross organelle stress response disruption promotes gentamicin-induced proteotoxicity
Authors: Igwebuike Chinaemere , Yaglom Julia , Huiting Leah , Feng Hui , Campbell Joshua D. , Wang Zhiyong , Havasi Andrea , Pimentel David , Sherman Michael Y. , Borkan Steven C. 
Published: April 2020

AbstractGentamicin is a nephrotoxic antibiotic that causes acute kidney injury (AKI) primarily by targeting the proximal tubule epithelial cell. The development of an effective therapy for gentamicin-induced renal cell injury is limited by incomplete mechanistic insight. To address this challenge, we propose that RNAi signal pathway screening could identify a unifying mechanism of gentamicin-induced cell injury and suggest a therapeutic strategy to ameliorate it. Computational analysis of RNAi signal screens in gentamicin-exposed human proximal tubule cells suggested the cross-organelle stress response (CORE), the unfolded protein response (UPR), and cell chaperones as key targets of gentamicin-induced injury. To test this hypothesis, we assessed the effect of gentamicin on the CORE, UPR, and cell chaperone function, and tested the therapeutic efficacy of enhancing cell chaperone content. Early gentamicin exposure disrupted the CORE, evidenced by a rise in the ATP:ADP ratio, mitochondrial-specific H2O2 accumulation, Drp-1-mediated mitochondrial fragmentation, and endoplasmic reticulum–mitochondrial dissociation. CORE disruption preceded measurable increases in whole-cell oxidative stress, misfolded protein content, transcriptional UPR activation, and its untoward downstream effects: CHOP expression, PARP cleavage, and cell death. Geranylgeranylacetone, a therapeutic that increases cell chaperone content, prevented mitochondrial H2O2 accumulation, preserved the CORE, reduced the burden of misfolded proteins and CHOP expression, and significantly improved survival in gentamicin-exposed cells. We identify CORE disruption as an early and remediable cause of gentamicin proteotoxicity that precedes downstream UPR activation and cell death. Preserving the CORE significantly improves renal cell survival likely by reducing organelle-specific proteotoxicity during gentamicin exposure.
Rapid time-resolved Circular Polarization Luminescence (CPL) emission spectroscopy
Authors: MacKenzie Lewis E. , Pålsson Lars-Olof , Parker David , Beeby Andrew , Pal Robert 
Published: April 2020

AbstractCircular polarisation luminescence (CPL) emission spectroscopy is a powerful tool for probing the fundamental chiroptical features of optically emissive chiral molecular systems. However, uptake of CPL spectroscopy has been impeded by the limitations of conventional scanning monochromator (SM) CPL spectrometers, which are costly to acquire and maintain, and typically require tens of minutes to acquire a typical CPL spectrum. Here, we demonstrate a design of CPL spectrometer which uses rapid readout solid state (SS) spectrometer detectors and a dual channel optical layout to acquire CPL spectra in as little as 10 milliseconds. We validate and demonstrate equivalent CPL measurement by measuring CPL spectra of two reference europium(III) complexes. Further, we demonstrate time-gated CPL acquisition, enabling long-lived CPL luminescence to be distinguished from short-lived emission of other fluorescent species. We anticipate that SS-CPL spectrometers will enable flexible, rapid, and relatively low-cost CPL spectroscopy for diverse applications.
Intercellular communication between artificial cells by allosteric amplification of a molecular signal
Authors: Buddingh’ Bastiaan C. , Elzinga Janneke , van Hest Jan C. M. 
Published: April 2020

AbstractMulticellular organisms rely on intercellular communication to coordinate the behaviour of individual cells, which enables their differentiation and hierarchical organization. Various cell mimics have been developed to establish fundamental engineering principles for the construction of artificial cells displaying cell-like organization, behaviour and complexity. However, collective phenomena, although of great importance for a better understanding of life-like behaviour, are underexplored. Here, we construct collectives of giant vesicles that can communicate with each other through diffusing chemical signals that are recognized and processed by synthetic enzymatic cascades. Similar to biological cells, the Receiver vesicles can transduce a weak signal originating from Sender vesicles into a strong response by virtue of a signal amplification step, which facilitates the propagation of signals over long distances within the artificial cell consortia. This design advances the development of interconnected artificial cells that can exchange metabolic and positional information to coordinate their higher-order organization.
METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice
Authors: Wang Yuqin , Gao Ming , Zhu Fuxing , Li Xinzhi , Yang Ying , Yan Qiuxin , Jia Linna , Xie Liwei , Chen Zheng 
Published: April 2020

AbstractBrown adipose tissue (BAT) undergoes rapid postnatal development and then protects against cold and obesity into adulthood. However, the molecular mechanism that determines postnatal development and maturation of BAT is largely unknown. Here we show that METTL3 (a key RNA methyltransferase) expression increases significantly in interscapular brown adipose tissue (iBAT) after birth and plays an essential role in the postnatal development and maturation of iBAT. BAT-specific deletion of Mettl3 severely impairs maturation of BAT in vivo by decreasing m6A modification and expression of Prdm16, Pparg, and Ucp1 transcripts, which leads to a marked reduction in BAT-mediated adaptive thermogenesis and promotes high-fat diet (HFD)-induced obesity and systemic insulin resistance. These data demonstrate that METTL3 is an essential regulator that controls iBAT postnatal development and energy homeostasis.
Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation
Authors: Hamarsheh Shaima’a , Osswald Lena , Saller Benedikt S. , Unger Susanne , De Feo Donatella , Vinnakota Janaki Manoja , Konantz Martina , Uhl Franziska M. , Becker Heiko , Lübbert Michael , Shoumariyeh Khalid , Schürch Christoph , Andrieux Geoffroy , Venhoff Nils , Schmitt-Graeff Annette , Duquesne Sandra , Pfeifer Dietmar , Cooper Matthew A. , Lengerke Claudia , Boerries Melanie , Duyster Justus , Niemeyer Charlotte M. , Erlacher Miriam , Blazar Bruce R. , Becher Burkard , Groß Olaf , Brummer Tilman , Zeiser Robert 
Published: April 2020

AbstractOncogenic Ras mutations occur in various leukemias. It was unclear if, besides the direct transforming effect via constant RAS/MEK/ERK signaling, an inflammation-related effect of KRAS contributes to the disease. Here, we identify a functional link between oncogenic KrasG12D and NLRP3 inflammasome activation in murine and human cells. Mice expressing active KrasG12D in the hematopoietic system developed myeloproliferation and cytopenia, which is reversed in KrasG12D mice lacking NLRP3 in the hematopoietic system. Therapeutic IL-1-receptor blockade or NLRP3-inhibition reduces myeloproliferation and improves hematopoiesis. Mechanistically, KrasG12D-RAC1 activation induces reactive oxygen species (ROS) production causing NLRP3 inflammasome-activation. In agreement with our observations in mice, patient-derived myeloid leukemia cells exhibit KRAS/RAC1/ROS/NLRP3/IL-1β axis activity. Our findings indicate that oncogenic KRAS not only act via its canonical oncogenic driver function, but also enhances the activation of the pro-inflammatory RAC1/ROS/NLRP3/IL-1β axis. This paves the way for a therapeutic approach based on immune modulation via NLRP3 blockade in KRAS-mutant myeloid malignancies.
Comprehensive scan for nonmagnetic Weyl semimetals with nonlinear optical response
Authors: Xu Qiunan , Zhang Yang , Koepernik Klaus , Shi Wujun , van den Brink Jeroen , Felser Claudia , Sun Yan 
Published: April 2020

AbstractFirst-principles calculations have recently been used to develop comprehensive databases of nonmagnetic topological materials that are protected by time-reversal or crystalline symmetry. However, owing to the low symmetry requirement of Weyl points, a symmetry-based approach to identifying topological states cannot be applied to Weyl semimetals (WSMs). To date, WSMs with Weyl points in arbitrary positions are absent from the well-known databases. In this work, we develop an efficient algorithm to search for Weyl points automatically and establish a database of nonmagnetic WSMs with Weyl points near the Fermi level based on the experimental non-centrosymmetric crystal structures in the Inorganic Crystal Structure Database (ICSD). In total, 46 Weyl semimetals were discovered to have nearly clean Fermi surfaces and Weyl points within 300 meV of the Fermi level. Nine of them are chiral structures which may exhibit the quantized circular photogalvanic effect. In addition, the nonlinear optical response is studied and the giant shift current is explored. Besides nonmagnetic WSMs, our powerful tools can also be used in the discovery of magnetic topological materials.
Near-field corrosion interactions between glass and corrosion resistant alloys
Authors: Guo Xiaolei , Gin Stephane , Liu Hongshen , Ngo Dien , Luo Jiawei , Kim Seong H. , Mohanty Chandi , Vienna John D. , Ryan Joseph V. , Frankel Gerald S. 
Published: April 2020

AbstractThis study explores the corrosion interactions between model nuclear waste glass materials and corrosion resistant alloys, under accelerated conditions that simulate the near field of a nuclear waste repository. The interactions between the corrosion of stainless steel (SS) 316, alloy G30, or alloy 625, and international simple glass or soda-lime silica glass are systematically studied. The dissimilar materials were exposed in close proximity to each other in different electrolytes at 90 °C. After exposure, the glass surface exposed near metals showed different regimes of corrosion, with distinct surface morphologies and chemistries that were likely affected by the local environment created by the localized corrosion of metals. Surface and solution analyses showed that the corrosion rate of glass was enhanced by the presence of metals. Infrared spectroscopy data suggested the local build-up of stresses in the contact area of glass, which may lead to the mechanical instability of the glass alteration layer. On the other hand, the effect of glass on metal corrosion is strongly dependent on the leaching solution. In electrolytes containing abundant aggressive anions such as Cl−, glass seems to suppress the localized corrosion of SS by the precipitation of a Si-rich surface film that protects the SS substrate from solutions. However, in less aggressive electrolytes, the corrosion rate of SS was increased by the presence of glass corrosion products. Overall, our study showed that the hidden and localized damage on glass in contact with metals may enhance the release rate of glass components compared to typical uniform glass corrosion.
On-demand generation and characterization of a microwave time-bin qubit
Authors: Ilves J. , Kono S. , Sunada Y. , Yamazaki S. , Kim M. , Koshino K. , Nakamura Y. 
Published: April 2020

AbstractSuperconducting circuits offer a scalable platform for the construction of large-scale quantum networks, where information can be encoded in multiple temporal modes of propagating microwaves. Characterization of such microwave signals with a method extendable to an arbitrary number of temporal modes with a single detector and demonstration of their phase-robust nature are of great interest. Here, we show the on-demand generation and Wigner tomography of a microwave time-bin qubit with superconducting circuit quantum electrodynamics architecture. We perform the tomography with a single heterodyne detector by dynamically switching the measurement quadrature independently for two temporal modes through the pump phase of a phase-sensitive amplifier. We demonstrate that the time-bin encoding scheme relies on the relative phase between the two modes and does not need a shared phase reference between sender and receiver.