bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer’s disease models and human brains
Authors: Vaillant-Beuchot Loan , Mary Arnaud , Pardossi-Piquard Raphaëlle , Bourgeois Alexandre , Lauritzen Inger , Eysert Fanny , Kinoshita Paula Fernanda , Cazareth Julie , Badot Céline , Fragaki Konstantina , Bussiere Renaud , Martin Cécile , Mary Rosanna , Bauer Charlotte , Pagnotta Sophie , Paquis-Flucklinger Véronique , Buée-Scherrer Valérie , Buée Luc , Lacas-Gervais Sandra , Checler Frédéric , Chami Mounia 
Published: October 2020

AbstractSeveral lines of recent evidence indicate that the amyloid precursor protein-derived C-terminal fragments (APP-CTFs) could correspond to an etiological trigger of Alzheimer’s disease (AD) pathology. Altered mitochondrial homeostasis is considered an early event in AD development. However, the specific contribution of APP-CTFs to mitochondrial structure, function, and mitophagy defects remains to be established. Here, we demonstrate in neuroblastoma SH-SY5Y cells expressing either APP Swedish mutations, or the β-secretase-derived APP-CTF fragment (C99) combined with β- and γ-secretase inhibition, that APP-CTFs accumulation independently of Aβ triggers excessive mitochondrial morphology alteration (i.e., size alteration and cristae disorganization) associated with enhanced mitochondrial reactive oxygen species production. APP-CTFs accumulation also elicit basal mitophagy failure illustrated by enhanced conversion of LC3, accumulation of LC3-I and/or LC3-II, non-degradation of SQSTM1/p62, inconsistent Parkin and PINK1 recruitment to mitochondria, enhanced levels of membrane and matrix mitochondrial proteins, and deficient fusion of mitochondria with lysosomes. We confirm the contribution of APP-CTFs accumulation to morphological mitochondria alteration and impaired basal mitophagy in vivo in young 3xTgAD transgenic mice treated with γ-secretase inhibitor as well as in adeno-associated-virus-C99 injected mice. Comparison of aged 2xTgAD and 3xTgAD mice indicates that, besides APP-CTFs, an additional contribution of Aβ to late-stage mitophagy activation occurs. Importantly, we report on mitochondrial accumulation of APP-CTFs in human post-mortem sporadic AD brains correlating with mitophagy failure molecular signature. Since defective mitochondria homeostasis plays a pivotal role in AD pathogenesis, targeting mitochondrial dysfunctions and/or mitophagy by counteracting early APP-CTFs accumulation may represent relevant therapeutic interventions in AD.
Short- and long-term outcomes for primary anastomosis versus Hartmann’s procedure in Hinchey III and IV diverticulitis: a multivariate logistic regression analysis of risk factors
Authors: Facile Ivan , Galli Raffaele , Dinter Pavlo , Rosenberg Robert , Von Flüe Markus , Steinemann Daniel Christian , Posabella Alberto , Droeser Raoul André 
Published: October 2020

AbstractPurposeThe management of perforated diverticulitis with generalized peritonitis is still controversial and no preferred standardized therapeutic approach has been determined. We compared surgical outcomes between Hartmann’s procedure (HP) and primary anastomosis (PA) in patients with Hinchey III and IV perforated diverticulitis.MethodsMulticenter retrospective analysis of 131 consecutive patients with Hinchey III and IV diverticulitis operated either with HP or PA from 2015 to 2018. Postoperative morbidity was compared after adjustment for known risk factors in a multivariate logistic regression.ResultsSixty-six patients underwent HP, while PA was carried out in 65 patients, 35.8% of those were defunctioned. HP was more performed in older patients (74.6 vs. 61.2 years,p < .001), with Hinchey IV diverticulitis (37% vs. 7%,p < .001) and in patients with worse prognostic scores (P-POSSUM Physiology Score,p < .001, Charlson Comorbidity Indexp < .001). Major morbidity and mortality were higher in HP compared to PA (30.3% vs. 9.2%,p = .002 and 10.6% vs. 0%,p = .007, respectively) with lower stoma reversal rate (43.9% vs. 86.9%,p < .001). In a multivariate logistic regression, PA was independently associated with lower postoperative morbidity and mortality (OR 0.24, 95% CI 0.06–0.96,p = .044).ConclusionsIn comparison to PA, HP is associated with a higher morbidity, higher mortality, and a lower stoma reversal rate. Although a higher prevalence of risk factors in HP patients may explain these outcomes, a significant increase in morbidity and mortality persisted in a multivariate logistic regression analysis that was stratified for the identified risk factors.
Exotic garden plants partly substitute for native plants as resources for pollinators when native plants become seasonally scarce
Authors: Staab Michael , Pereira-Peixoto Maria Helena , Klein Alexandra-Maria 
Published: October 2020

AbstractUrban green spaces such as gardens often consist of native and exotic plant species, which provide pollen and nectar for flower-visiting insects. Although some exotic plants are readily visited by pollinators, it is unknown if and at which time of the season exotic garden plants may supplement or substitute for flower resources provided by native plants. To investigate if seasonal changes in flower availability from native vs. exotic plants affect flower visits, diversity and particularly plant–pollinator interaction networks, we studied flower-visiting insects over a whole growing season in 20 urban residential gardens in Germany. Over the course of the season, visits to native plants decreased, the proportion of flower visits to exotics increased, and flower-visitor species richness decreased. Yet, the decline in flower-visitor richness over the season was slowed in gardens with a relatively higher proportion of flowering exotic plants. This compensation was more positively linked to the proportion of exotic plant species than to the proportion of exotic flower cover. Plant–pollinator interaction networks were moderately specialized. Interactions were more complex in high summer, but interaction diversity, linkage density, and specialisation were not influenced by the proportion of exotic species. Thus, later in the season when few native plants flowered, exotic garden plants partly substituted for native flower resources without apparent influence on plant–pollinator network structure. Late-flowering garden plants support pollinator diversity in cities. If appropriately managed, and risk of naturalisation is minimized, late-flowering exotic plants may provide floral resources to support native pollinators when native plants are scarce.
Evaluation of new motorized articulating laparoscopic instruments by laparoscopic novices using a standardized laparoscopic skills curriculum
Authors: Uysal Daniel , Gasch Claudia , Behnisch Rouven , Nickel Felix , Müller-Stich Beat Peter , Hohenfellner Markus , Teber Dogu 
Published: October 2020

Abstract
Background
Motorized articulating laparoscopic instruments (ALI) offer more degrees of freedom than conventional laparoscopic instruments (CLI). However, a difficult learning curve and complex instrument handling are still a problem of ALI. We compared the performance of new prototypes of motorized ALI with CLI in a series of standardized laparoscopic tasks performed by laparoscopic novices. Further, usability of the new ALI was assessed.

Methods
A randomized cross-over study with 50 laparoscopic novices who either started with CLI and then changed to ALI (CA) or vice versa (AC) was conducted. All participants performed the European training in basic laparoscopic urological skills (E-BLUS) with each instrument in given order. Time and errors were measured for each exercise. Instrument usability was assessed.

Results
Overall, using CLI was significantly faster (CLI 4:27 min vs. ALI 4:50 min; p-value 0.005) and associated with fewer exercise failures in needle guidance (CLI 0 vs. ALI 12; p-value 0.0005) than ALI. Median amount of errors was similar for both instruments. Instrument sequence did not matter, as CA and AC showed comparable completion times. Regarding the learning effect, participants were significantly faster in the second attempt of exercises than in the first. In the needle guidance task, participants using CLI last demonstrated a significant speed improvement, whereas ALI were significantly slower in the second run. Regarding usability, CLI were preferred over ALI due to lighter weight and easier handling. Nevertheless, participants valued ALI’s additional degrees of freedom.

Conclusion
Using new motorized ALI in the E-BLUS examination by laparoscopic novices led to a worse performance compared to CLI. An explanation could be that participants felt overwhelmed by ALI and that ALI have an own distinct learning curve. As participants valued ALI’s additional degrees of freedom, however, a future application of ALI could be for training purposes, ideally in combination with CLI.
A teleconnection between sea surface temperature in the central and eastern Pacific and wintertime haze variations in southern China
Authors: Cheng Xugeng , Liu Jane , Zhao Tianliang , Gong Sunling , Xu Xiangde , Xie Xiaoning , Wang Rong 
Published: October 2020

AbstractHaze pollution in recent decades varies largely with both pollutant emissions and meteorological conditions. Using the discrete wavelet transform (DWT) method, we separate these two influences on haze variations in southern China in the time series of haze observations from 1981 to 2011. This helps us to identify the meteorological influence on interannual variation in haze occurrences in southern China and thus observe a teleconnection between the thermal forcing of sea surface temperature (SST) in the central and eastern Pacific and wintertime haze occurrences in southern China (R = − 0.51, p < 0.05). The total haze days in winter is highest among all seasons over southern China and the climotological mean of number of winter haze days is 7.5 days for the region. Compared with the normal winters, the regional mean of the number of haze days in southern China is reduced by ~ 5 days in the winters with above-normal Niño3.4 SST (during El Niño phases), but increased by ~ 4 days in the winters with below-normal Niño3.4 SST (during La Niña phases). In the warm SST winters, the cumulative consequences of strong winds, more precipitation, and a more unstable atmosphere with an “upper colder and lower warmer” vertical pattern leading to more ascendance can all hinder haze formation, whereas in the cold SST winters, opposite meteorological conditions are favorable to haze formation. These meteorological conditions induced by anomalous SST make wintertime haze pollution in southern China vary from year to year to a large extent. This study suggests a strong sensitivity of winter haze occurrences in southern China to the viability of the SST in the central and eastern Pacific.
Scoping the ethical principles of cybersecurity fear appeals
Authors: Dupuis Marc , Renaud Karen 
Published: October 2020

AbstractFear appeals are used in many domains. Cybersecurity researchers are also starting to experiment with fear appeals, many reporting positive outcomes. Yet there are ethical concerns related to the use of fear to motivate action. In this paper, we explore this aspect from the perspectives of cybersecurity fear appealdeployersandrecipients. We commenced our investigation by considering fear appeals from three foundational ethical perspectives. We then consulted the two stakeholder groups to gain insights into the ethical concerns they consider to be pertinent. We first consulteddeployers: (a) fear appeal researchers and (b) Chief Information Security Officers (CISOs), and then potential cybersecurity fear appealrecipients:members of a crowdsourcing platform. We used their responses to develop aneffects-reasoning matrix, identifying the potential benefits and detriments of cybersecurity fear appeals for all stakeholders. Using these insights, we derived six ethical principles to guide cybersecurity fear appeal deployment. We then evaluated a snapshot of cybersecurity studies using the ethical principle lens. Our contribution is,first, a list of potential detriments that could result from the deployment of cybersecurity fear appeals andsecond, the set of six ethical principles to inform the deployment of such appeals. Both of these are intended to inform cybersecurity fear appeal design and deployment.
Multiphysics Modelling of Stone Wool Fire Resistance
Authors: Paudel Deepak , Rinta-Paavola Aleksi , Mattila Hannu-Petteri , Hostikka Simo 
Published: October 2020

AbstractIn fire resistance tests, stone wool’s organic matter undergoes exothermic oxidative reactions sustained by external heat, causing mass transfer in the structure. The previous modelling attempts, lacking the mass transfer physics, fall short in predicting the temperature of high density and high organic content samples. To fill this gap in the fire engineering modelling capability, we include mass transfer in our calculation, and validate the model using experimental fire resistance data. As an alternative, we use a heat conduction -based model lacking the gas transfer but with reaction kinetics coupled to the stone wool’s organic mass %. The results show that the thermal effects of the oxidative degradation can be predicted by introducing the simplified diffusion processes. The oxygen transfer and exothermic reactions depend upon the amount of organic content, and the uncertainty of temperature predictions is $$\pm \,20\%$$

±

20
%

. In average, temperatures and critical times are more accurately predicted by the heat conduction model, while, the peak temperature prediction uncertainty is low ($$\pm \,10\%$$

±

10
%

) with the multiphysics model. The uncertainty compensation method reduces the difference between the two model predictions. Nevertheless, further validation study is needed to generalize the uncertainty compensation metrics. Finally, we demonstrate how a gas flow barrier on the cold side (sandwich) can effectively reduce the peak temperature of the high organic content-stone wools.
High thermal conductive copper/diamond composites: state of the art
Authors: Jia S. Q. , Yang F. 
Published: October 2020

AbstractCopper/diamond composites have drawn lots of attention in the last few decades, due to its potential high thermal conductivity and promising applications in high-power electronic devices. However, the bottlenecks for their practical application are high manufacturing/machining cost and uncontrollable thermal performance affected by the interface characteristics, and the interface thermal conductance mechanisms are still unclear. In this paper, we reviewed the recent research works carried out on this topic, and this primarily includes (1) evaluating the commonly acknowledged principles for acquiring high thermal conductivity of copper/diamond composites that are produced by different processing methods; (2) addressing the factors that influence the thermal conductivity of copper/diamond composites; and (3) elaborating the interface thermal conductance problem to increase the understanding of thermal transferring mechanisms in the boundary area and provide necessary guidance for future designing the composite interface structure. The links between the composite’s interface thermal conductance and thermal conductivity, which are built quantitatively via the developed models, were also reviewed in the last part.
Loneliness and Well-Being During the Covid-19 Pandemic: Associations with Personality and Emotion Regulation
Authors: Gubler Danièle A. , Makowski Lisa M. , Troche Stefan J. , Schlegel Katja 
Published: October 2020

AbstractThe present study examined how neuroticism, extraversion, and emotion regulation were related to loneliness and well-being during 6 weeks of major public life restrictions in the Covid-19 pandemic in Switzerland. Cross-sectional results from 466 participants showed that neuroticism and emotion regulation strategies were associated with higher loneliness and lower well-being. However, in contrast to prior research, associations of extraversion with loneliness and well-being were weak and were qualified by interactions with emotion regulation. For introverts, maladaptive cognitive strategies such as rumination or catastrophizing were related to higher levels of loneliness. For extraverts, emotion suppression was related to lower levels of affective well-being. Individuals with low maladaptive regulation reported higher well-being the longer the public life restrictions were in place at the time of study participation. These findings suggest that first, extraversion may lose some of its protective value for loneliness and well-being when opportunities to engage in social activities are limited; second, that loneliness and well-being do not decrease over 6 weeks of public life restrictions; and third, that future studies should further investigate the moderating role of emotion regulation on the link between personality, loneliness, and well-being.
Capture the variation of the pore pressure with different geological age from seismic inversion study in the Jaisalmer sub-basin, India
Authors: Chahal Raman , Datta Gupta Saurabh 
Published: October 2020

AbstractGeoscientific evidence shows that various parameters such as compaction, buoyancy effect, hydrocarbon maturation, gas effect and tectonic activities control the pore pressure of sub-surface geology. Spatially controlled geoscientific data in the tectonically active areas is significantly useful for robust estimation of pre-drill pore pressure. The reservoir which is tectonically complex and pore pressure is changing frequently that circumference motivated us to conduct this study. The changes in pore pressure have been captured from the fine-scale to the broad scale in the Jaisalmer sub-basin. Pore pressure variation has been distinctly observed in pre- and post-Jurassic age based on the current study. Post-stack seismic inversion study was conducted to capturing the variation of pore pressure. Analysis of low-frequency spectrum and integrated interval velocity model provided a detailed feature of pore pressure in each compartment of the study area. Pore pressure estimated from well log data was correlated with seismic inversion based result. Based on the current study one well has been proposed where pore pressure was estimated and two distinguished trends are identified in the study zone. The approaches of the current study were analysed thoroughly and it will be highly useful in complex reservoir condition where pore pressure varies frequently.
Histochemical Characterization of the Vestibular Y-Group in Monkey
Authors: Zeeh Christina , Mayadali Ümit S. , Horn Anja K.E. 
Published: October 2020

AbstractThe Y-group plays an important role in the generation of upward smooth pursuit eye movements and contributes to the adaptive properties of the vertical vestibulo-ocular reflex. Malfunction of this circuitry may cause eye movement disorders, such as downbeat nystagmus. To characterize the neuron populations in the Y-group, we performed immunostainings for cellular proteins related to firing characteristics and transmitters (calretinin, GABA-related proteins and ion channels) in brainstem sections of macaque monkeys that had received tracer injections into the oculomotor nucleus. Two histochemically different populations of premotor neurons were identified: The calretinin-positive population represents the excitatory projection to contralateral upgaze motoneurons, whereas the GABAergic population represents the inhibitory projection to ipsilateral downgaze motoneurons. Both populations receive a strong supply by GABAergic nerve endings most likely originating from floccular Purkinje cells. All premotor neurons express nonphosphorylated neurofilaments and are ensheathed by strong perineuronal nets. In addition, they contain the voltage-gated potassium channels Kv1.1 and Kv3.1b which suggests biophysical similarities to high-activity premotor neurons of vestibular and oculomotor systems. The premotor neurons of Y-group form a homogenous population with histochemical characteristics compatible with fast-firing projection neurons that can also undergo plasticity and contribute to motor learning as found for the adaptation of the vestibulo-ocular reflex in response to visual-vestibular mismatch stimulation. The histochemical characterization of premotor neurons in the Y-group allows the identification of the homologue cell groups in human, including their transmitter inputs and will serve as basis for correlated anatomical-neuropathological studies of clinical cases with downbeat nystagmus.
Biological response modifier glucan through balancing of blood glucose may have a prophylactic potential in COVID-19 patients
Authors: Ikewaki Nobunao , Iwasaki Masaru , Abraham Samuel J. K. 
Published: October 2020

AbstractWith the COVID-19 pandemic causing huge threat to public health and definite treatment modalities and preventive vaccines yet to be arrived at, some of the key indicators of relevance to its prognosis have started emerging. One such independent predictor of outcome has been fasting plasma glucose (FPG) at the time of admission. Earlier, co-morbidities such as diabetes also have been reported to have a risk of relatively increased mortality due to COVID-19. In this background, we herein report on the beneficial effects of Biological response modifier glucan (BRMG) secreted by the black yeast Aureobasidium pullulans AFO-202 which has been proven to bring under control blood sugar levels in human subjects and also has potential in enhancing & regulating the immune parameters in relevance to COVID-19. We further recommend that this BRMG be tried in clinical studies of COVID-19 to provide a prophylactic effect for validation.
18F-FDG PET/MRI in adult sarcomas
Authors: Cassarino Gianluca , Evangelista Laura , Giraudo Chiara , Capizzi Alfio , Carretta Giovanni , Zucchetta Pietro , Cecchin Diego 
Published: October 2020

Abstract
Aim
This mini-review aims to summarize the main findings on PET/MRI in patients with sarcomas.

Materials and methods
A literature search was carried out on MEDLINE databases, such as PubMed, Scopus, Web of Science and Google Scholar, using the search terms “PET”, “positron emission tomography”, “PET/MRI”, “positron emission tomography/magnetic resonance imaging”, and “sarcoma”. No restrictions (i.e. language, age, type of manuscript, or the like) were applied to the search strategy. Abstracts, reviews, letters to editors, and editorials were excluded.

Results
Eight studies were ultimately included. From 2013 to 2019, a total of 154 adult patients with sarcomas underwent 18F-fluorodeoxyglucose (18F-FDG) PET/MRI. Of these patients, 129 had soft tissue sarcomas (STS), 5 had bone sarcomas, and 20 had cardiac masses. Thirty-two patients had PET/MRI for early-stage disease, 45 for recurrences, and 57 for the assessment of response to treatment. For staging purposes, the studies suggest that PET/MRI can significantly improve the delineation of surgical margins. At restaging, PET/MRI can also detect sarcoma recurrences more accurately than conventional imaging.

Conclusions
18F-FDG PET/MRI has promising indications in patients with sarcomas, from disease staging to the assessment of response to treatment. Further studies are warranted to confirm these results, especially in subgroups with specific histopathological features.