bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using Web Conferencing to Engage Aboriginal and Torres Strait Islander Young People in Research: A Feasibility Study
Authors: Anderson Kate , Gall Alana , Butler Tamara , Arley Brian , Howard Kirsten , Cass Alan , Garvey Gail 
Published: December 2020

Abstract
Background: While web conferencing technologies are being widely used in communication and collaboration, their uptake in conducting research field work has been relatively slow. The benefits that these technologies offer researchers for engaging with hard-to-reach populations are beginning to be recognised, however, the acceptability and feasibility of using web conferencing technology to engage Aboriginal and Torres Strait Islander young people in research is unknown.Objective: This study aims to evaluate whether the use of web conferencing to engage Aboriginal and Torres Strait Islander young people in research is an acceptable and feasible alternative to conventional face-to-face methods. Methods: Aboriginal and Torres Strait Islander young people aged between 18-24 years were recruited via emails, flyers and snowballing to participate in an Online Yarning Circle (OYC) about wellbeing conducted via web conferencing. Five young Aboriginal and Torres Strait Islander Australians were trained as peer facilitators and each conducted one or more OYCs with support from an experienced Aboriginal and Torres Strait Islander researcher. The OYCs were recorded and the researchers conducted post-OYC interviews with the facilitators. OYC recordings, facilitator interviews and researchers’ reflections about the method were analysed to assess acceptability and feasibility for use with this population. Results: 11 OYCs were conducted with 21 participants. The evaluation focused on (a) acceptability of the method for participants and facilitators and (b) feasibility of data collection method and procedures for use in research. Our evaluation revealed good acceptability and feasibility of the method, with only minor challenges experienced, which were predominantly logistical in nature and related to scheduling, obtaining documentation of consent, and technical issues. These challenges were offset by the greater control over the level of engagement that was comfortable for individual participants and the greater ease with which they felt they could withdraw from participating. This shift in the traditional researcher-participant power dynamic was recognised by both participants and peer facilitators and was regarded as a support for Aboriginal and Torres Strait Islander young people’s participation in research.Conclusions: The use of web conferencing to engage Aboriginal and Torres Strait Islander young people in research offers an acceptable and feasible alternative to face-to-face research methods. The benefits conferred by these technologies associated with yielding greater control and power to the research participant has broad relevance to research with marginalised populations.
Clinical and Radiographic Variables Around Implant With Simultaneous Graft Among Type 2 Diabetic Patients Treated With Different Hypoglycemic Medications: A Retrospective Study.
Authors: Shi Shaojie , Ding Feng , Liu Xiangdong , Wang Lei , Wang Xingxing , Zhang Sijia , Zhao Guoqiang , Song Yingliang 
Published: December 2020

Abstract
Background: The clinical and radiographic variables around dental implants in type 2 diabetes mellitus patients with different hypoglycemic agents still remained unclear.Methods: This retrospective cohort study collected the dental records and digital periapical radiographs of type 2 diabetes mellitus patients and implants. These patients were grouped according to their medication: insulin, metformin, and glucagon-like peptide-1 drugs. The radiographic marginal bone loss around implants and clinical parameters, including peri-implant bleeding on probing and probing depth, were compared among groups using the Kruskal-Wallis test.Results: A total of 150 patients with 308 implants (101 in insulin group, 121 in metformin group and 86 in glucagon-like peptide-1 drugs group) were assessed. The peri-implants marginal bone loss in insulin group (P<0.05) and metformin group (P<0.01) were significantly higher than glucagon-like peptide-1 drug group. The radiographic bone loss in metformin was higher than insulin group (P<0.05). While there was no statistical difference of clinical peri-implant parameters among groups(P>0.05).Conclusions: The radiographic variables were not exactly the same among type 2 diabetes mellitus patients with different hypoglycemic agents. glucagon-like peptide-1 drugs might be more beneficial to bone tissue around implants. More studies are needed to verify the direct effect of these drugs on peri-implant bone.Clinical trial registration number: ChiCTR2000034211 (retrospectively registered)
The Significance of Routine Biochemical Markers in Patients With Sepsis
Authors: Meng Yan , Wang Yue , Qiao Wenbin , LIU Yumei , Wang Liang , Fan Jiahui , Tian Fengming , Wang Xuanzheng , Zhang Tao , Ma Xiumin 
Published: December 2020

Abstract
Background: Sepsis is a highly complex and fatal syndrome. It is the main cause of death in the intensive care unit. Early diagnosis is beneficial to reduce the mortality of sepsis and improve the prognosis of patients. Therefore, we look forward to finding cheap and fast diagnostic criteria to quickly assess the patient's condition.Methods: This is a retrospective study. The study enrolled 499 patients in the First Affiliated Hospital of Xinjiang Medical University from January 1, 2018 to June 22, 2020, and 96 healthy cases in the same period. Using the diagnostic criteria of bacterial infection, SIRS criteria and Sepsis-2 consensus criteria, 499 patients and 96 healthy cases were divided into 4 groups: sepsis group (n=300), SIRS group (n=151), infection group (n= 48), the control group (n=96). We collected the results of routine laboratory tests, inflammation indicators and blood culture results of these patients. Results: The sepsis group compared with the control group, MCV, NE, WBC, PLT, HB, D-Dimer, PT, CRP, PCT, IL-6, ALB, TBIL, Cr, LAC, CysC and BNP were statistically significant. D-dimer, CRP and PCT have higher diagnostic efficiency. Compared with the difference between the infection group and the SIRS group, PLT and IL-6 are statistically significant, and have a certain diagnostic value. Sepsis group VS infection group, WBC, IL-6, NE and TBIL showed statistical differences in the comparison. The AUC of NE was 67.6, which was the largest among the three. The specificity (95.8%) was the highest, but the sensitivity (49%) was low.Conclusions: This retrospective study shows that NE, WBC, and D-dimer can help in the early diagnosis of sepsis. D-dimer performs best. WBC and NE may have a differential diagnosis significance between the sepsis group and the infection group. This result can provide a timely and convenient assessment tool for early diagnosis of sepsis.
Optimized fuzzy logic by Genetic algorithm for identifying the situation of social network users
Authors: khodayar Elham , safi seyyed mohammad , Alikhani Mahboobeh , Taheri Amin , Movaghar Ali , Aghajari Ebrahim 
Published: December 2020

Abstract
Today, mobile social networks and smartphones are highly developed and widely used. Owing to the transfer of vast amounts of data, information, and communication between users, such networks have addressed privacy as a fundamental issue. Recently, there has been a growing interest in identifying the privacy requirements of each user to act independently and dynamically according to the situations and conditions. This paper seeks to meet the privacy requirements of users by identifying their situation. For this purpose, we define a number of significant parameters in compliance with the conditions of users. Also, after inferring the current exact situation of the user, the fuzzy logic is automatically utilized to specify the privacy settings based on the conditions. To increase the accuracy in the identification of user situation, this method employs the genetic algorithm for selecting the coefficients of optimal input parameters in the fuzzy system. In this way, the fuzzy system is able to make a more accurate identification of the user situation. Compared to a similar method, the proposed method shows a better accuracy in identifying the user situation and, as a result, better performance in correctly setting the privacy.
Dangerous Zoning and Stability Assessment of Slopes at Antaibao Open Pit Coal Mine in China
Authors: TAO Zhigang , LIU keyuan , YANG Xiaojie , LI Jingtao , ZHANG Peng , LI Gengzhao 
Published: December 2020

Abstract
With the depletion of shallow coal resources in China, the depths and scales of mining have increased. For several coal mines, the extraction has changed from open-pit to underground. Due to open-pit and underground mining disturbance, landslide disasters frequently occur at high and steep slopes of open-pit mines. The effective identification of danger zone of slope and accurate determination of corresponding stability is important in the field of geotechnical engineering. Herein, Antaibao open-pit coal mine was employed as the research object. Firstly, as per the composition and structural characteristics of on-site slope rock mass, six typical disaster factors were summarized, while the assignment criteria for discrete and continuous variables were divided according to the landslide body characteristics and spatiotemporal distribution. Thereafter, based on the comprehensive evaluation principle of fuzzy mathematics, high and steep side stability in the multi-factor influence regions was comprehensively evaluated, while the spatial division of the unstable region was determined. Finally, the slope potential slip surface in the unstable zone of the western side was utilized as the calculation model object, and sensitivity analysis of the slope impact factor was conducted using the MSARMA method. Therefore, the earthquake as well as drainage rate (groundwater dynamics) were determined as the sensitivity factors. The numerical simulation of FLAC3D finite difference method was performed to analyze the evolution law of displacement field under natural, seepage, and vibrational conditions of the northwest slope.
The Painful Anterior Apprehension Test – An Indication of Occult Shoulder Instability
Authors: Ng Yau Hong , Law Gin Way , Ng Zhaowen Dennis , Tan Jun Hao , Wong Keng Lin Francis , Kumar V Prem 
Published: December 2020

Abstract
Background To evaluate the clinical relevance of the painful anterior apprehension test in shoulder instability.MethodsWe performed a retrospective study of 155 patients that underwent arthroscopic anterior Bankart repair between 2014–2016. Exclusion criteria were previous ipsilateral shoulder surgery, bony Bankart lesions, glenohumeral osteoarthritis and concomitant surgery involving rotator cuff tears, biceps tendon pathology and SLAP lesions. The study cohort was divided into 3 groups: apprehension test with apprehension only, apprehension test with pain only, and apprehension test with both apprehension and pain. Patient demographics, clinical characteristics, radiological imaging, arthroscopy findings and surgical outcomes (Constant, ASES, SF-36 scores) were evaluated.Results115 (74.2%) had apprehension only, 26 (16.8%) had pain only and 14 (9.0%) had pain and apprehension with the apprehension test. Univariate analysis showed significant differences between the groups in patients with traumatic shoulder dislocation (p=0.028), patients presenting with pain (p=0.014) and patients presenting with recurrent dislocations (p=0.046). Patients with a purely painful apprehension test were more likely to have a traumatic shoulder dislocation, more likely to present only with pain, and less likely to present with recurrent shoulder dislocations. Multivariate analysis showed that none of these factors alone were significant as single predictors for shoulder instability. All 3 groups were otherwise similar in patient profile, MRI and arthroscopic assessments, and clinical outcomes of surgery. Excellent clinical outcomes were achieved in all groups with no difference in preoperative and postoperative scores across all groups at all time points.ConclusionsThe painful apprehension test may suggest underlying shoulder instability.
Lay Persons Views on Current and Novel Methods of Fertility Assessment and Supporting Conception: A Qualitative Study
Authors: Ng Ka Ying Bonnie , Glowacka Marta , Dennison Laura , Cheong Ying 
Published: December 2020

Abstract
BackgroundThere is an ongoing trend towards delayed childbearing; 1 in 6 couples suffer from subfertility. For couples needing IVF, one factor hindering advances in this area is lack of knowledge on in-vivo uterine conditions. A novel intrauterine sensor is currently under development to measure the intrauterine environment, as an innovative means of fertility assessment. Our study explored women’s views of current and novel methods of fertility assessment. Methods A qualitative study was performed. A purposeful sampling method was used to recruit participants from public spaces within Southampton. Women were eligible if they were of reproductive age, planning a pregnancy, nulliparous and not undergoing clinical investigation/fertility treatment. Semi-structured interviews explored pregnancy planning, understanding and experiences of current/novel methods aiming to assess and improve fertility. Interviews were conducted until data saturation was reached (n=16). Inductive thematic analysis was performed. Results The main factors influencing the decision of when to ‘start trying’ were education, financial stability and relationship status. Pregnancy was seen as a ‘physiological’ event without the need for intervention. Participants lacked knowledge of fertility indicators and had limited knowledge of available products to assess fertility/support conception. Although participants generally perceived a novel intrauterine sensor as acceptable and valuable, the main concerns centred around invasiveness, safety and discomfort.ConclusionsWhen developing a novel medical device, healthcare professionals should be aware of the user’s knowledge and views at each stage. A clear added benefit over conventional methods is needed and addressing invasiveness, safety, and comfort may improve the acceptability of the device.
Production Forecast and Estimation of the Recovery Factor of the Los Humeros Geothermal Field, Mexico.
Authors: Gonzalez-Garcia Hector , Francke Henning , Sass Ingo , Huenges Ernst 
Published: December 2020

Abstract
Production data from the Los Humeros geothermal field in Mexico are used to develop a forecast method for operation of the field in the future. This method supports understanding the limitations of sustainably exploiting a geothermal reservoir. Using such forecasts, fluid extraction could be scheduled in order to fulfill the steam demand of the installed capacity. Moreover, the forecast of the extraction can diminish the commercial risk involved and therefore clear the way for new investments. Herein, we determined the total extracted heat from the Los Humeros geothermal system, with the aim to forecast the next phase of fluid extraction. We took the information from 29 producing wells to analyze their historic geothermal fluid production. From their statistical distribution of data, we estimated the amount of extracted fluids for a future phase. The size of the heat reserve previous to exploitation was calculated from the forecasted and the extracted heat. Thus, the recovery factor of the system was calculated as the ratio of the accumulated production of heat and the initial heat content. The general recovery factor for 60 years of production was calculated as 37…44 %. Due to the heterogeneity of the system, we conducted individual assessments. The forecasted heat extraction for the next thirty years of production, amounts to 580 PJ assuming a constant extraction rate between 6 and 56 ton·[hr]-1. The results of this study potentially complement the existing models of the geothermal exploitation and offers an estimation of the future production of the Los Humeros, which could be a good basis for decision-making and management of the site.
Hypoxia Modulation by Dual-drug Nanoparticles for Enhanced Synergistic Sonodynamic and Starvation Therapy
Authors: Wang Jingxue , Huang Ju , Zhou Weichen , Zhao Jiawen , Qi Peng , Zhang Liang , Wang Zhigang , Li Pan , Li Rui 
Published: December 2020

Abstract
Background: Sonodynamic therapy (SDT) is an emerging non-invasive therapeutic technique. SDT-based cancer therapy strategies are presently underway, and it may be perceived as a promising approach to improve the efficiency of anti-cancer treatment. In this work, multifunctional theranostic nanoparticles (NPs) were synthesized for synergistic starvation therapy and SDT by loading glucose oxidase (GOx, termed G) and 5,10,15,20-tetrakis (4-chlorophenyl) porphyrin) Cl (T (p-Cl) PPMnCl, termed PMnC) in Poly (lactic-co-glycolic) acid (PLGA) NPs (designated as MG@P NPs). Results: On account of the peroxidase-like activity of PMnC, MG@P NPs can catalyze hydrogen peroxide (H2O2) in tumor regions to produce oxygen (O2), thus enhancing synergistic therapeutic effects by accelerating the decomposition of glucose and promoting the production of cytotoxic singlet oxygen (1O2) induced by ultrasound (US) irradiation. Furthermore, the NPs can also serve as excellent photoacoustic (PA)/magnetic resonance (MR) imaging contrast agents, effectuating imaging-guided cancer treatment. Conclusion: Multifunctional MG@P NPs can effectuate the synergistic amplification effect of cancer starvation therapy and SDT by hypoxia modulation, and act as contrast agents to enhance MR/PA dual-modal imaging. Consequently, MG@P NPs might be a promising nano-platform for highly efficient cancer theranostics.
Delivery of Melittin Loaded Niosomes for Breast Cancer Treatment: an in-vitro and in-vivo Evaluation of Anti-cancer Effect
Authors: Moghaddam Farnaz Dabbagh , Akbarzadeh Iman , Marzbankia Ehsan , Farid Mahsa , Khaledi Leila , Reihani Amir Hossein , Javidfar Mehrnoosh , Mortazavi Pejman 
Published: December 2020

Abstract
BackgroundMelittin, a peptide component of honey bee venom, is an appealing candidate for cancer therapy. In the current study, Melittin and Melittin loaded niosome had been optimized and assessed the anticancer effect an In-Vitro on 4T1 and SKBR3 breast cell lines and In-Vivo on BALB/C inbred mice. "Thin-layer hydration method" was used for preparing the Niosomes; different niosomal formulations of Melittin were prepared and characterized in terms of morphology, size, Polydispersity index, encapsulation efficiency, release kinetics, and stability. A niosome was formulated and loaded with Melittin as a promising drug carrier system for chemotherapy of the breast cancer cells. Hemolysis, apoptosis, cell cytotoxicity, invasion and migration of selected concentrations of Melittin, and Melittin loaded niosome were evaluated on 4T1 and SKBR3 cells using hemolytic activity assay, flow cytometry, MTT assay, soft agar colony assay, and wound healing assay. Real-time PCR was used to determine the genes expression. 35 BALB/c inbred mice were used; then, the histopathology, P53 immunohistochemical assay and estimate of renal and liver enzyme activity for all groups had been done.Results: This study showed Melittin loaded niosome is an excellent substitute in breast cancer treatment due to enhanced targeting, encapsulation efficiency, PDI, and release rate and shows a high anticancer effect on cell lines. The Melittin loaded niosome affect the genes expression by studied cells were higher than other samples; down-regulates the expression of Bcl2, MMP2, and MMP9 genes while they up-regulate the expression of Bax, Caspase3 and Caspase9 genes. Also enhanced the apoptosis rate and inhibitored cell migration, invasion in both cell lines compared to the Melittin samples. Results of histopathology showed reduce mitosis index, invasion and pleomorphism in Melittin loaded niosome. Renal and hepatic biomarker activity did not show a significant difference in Melittin loaded niosome and Melittin compared to healthy control. In immunohistochemistry, P53 expression did not show a significant change in all groups.Conclusions: Our study successfully declares that Melittin loaded niosome had more anti-cancer effects than free Melittin. This project has demonstrated that Niosomes are suitable vesicle carriers for Melittin, compare to free form.
A Simple and Effective Method for Bleeding Control During Percutaneous Dilatational Tracheostomies
Authors: Du Xiuyu , Zhai Xiaodong , Liu Zhi , Teng Jinliang , Liu Chunyan 
Published: December 2020

Abstract
Objectives: This study describes an intradermal injection technique for reducing bleeding during a percutaneous dilatation tracheotomy (PDT).Methods: Fifty-two consecutively recruited patients who underwent PDTs were analysed in a prospective study that was conducted between May 2019 and January 2020. This is a prospective study and fifty-two patients who underwent PDT were recruited from May 2019 to January 2020. They were randomly divided into an observation group and a control group. The patients in the observation group accepted the execution of the intradermal injection technique during their local anaesthesia. A comparison was made between the two groups’ intraoperative bleeding, postoperative bleeding, operation time and length of incision.Results: A total of 52 patients were enrolled in this study, 33 males (63.5%) and 19 females. The mean age was 63.0±9.9 years, with the patients’ age ranging from 45 to 80 years. The mean BMI was 29.2±5.1 kg/m2. There was no significant difference in gender, age, BMI index and whether they had an endotracheal tube between the two groups (P > 0.05). The observation group’s intraoperative bleeding was less than that of control group (χ2 = 8.308, P = 0.009). There was no significant difference in operation time between the two groups (t = -0.904, P = 0.372). There was no PDT-related death.Conclusion: The intradermal injection technique can be used to effectively and safely reduce bleeding during PDTs. This technique provides a lower intraoperative bleeding grade without increased the procedure’s duration.
Activity and Function Studies of The&nbsp;Promoter Cis-Acting Elements of The Key Enzymes in Saponins Biosynthesis&nbsp;of DS From&nbsp;Panax Notoginseng
Authors: Zheng Yujie , Shao Rongyu , Xia Pengguo , Liang Zongsuo , Yan Kaijing 
Published: December 2020

Abstract
Background：Panax notoginseng is a traditional Chinese medicine for the treatment of blood diseases, in which saponins were the main active components. Dammarenediol synthase (DS) is a key enzyme in the saponin synthesis pathway of P. notoginseng.The promoter is an important region to regulate gene expression, and the study of the promoter sequence provides important evidence for revealing the mechanism of gene expression regulation. Methods: However, there was still little research on the promoter function of P. notoginseng. In this study, the 1382 bp promoter upstream of DS from P. notoginseng was cloned and sequenced. The promoter sequence was analyzed by online databases. The plant expression vector fused with the β-glucuronidase gene was constructed, transferred into Agrobacterium tumefaciens. Then tobacco was injected, and its response to exogenous hormones (gibberellin and abscisic acid) was studied by transient expression to verify its unique action elements. Results: The results showed that the tobacco leaves transferred with DS promoter had significantly increased GUS protease activity after spraying GA and ABA, indicating that both DS promoter can specifically and significantly respond to exogenous GA and ABA signal. Conclusions: These findings will help us to better understand the regulatory mechanisms of the upstream region of the DS gene and provide a basis for future research on the interaction of cis-acting elements of promoters with related transcription factors.