bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biparatopic sybody constructs neutralize SARS-CoV-2 variants of concern and mitigate emergence of drug resistance
Authors: Walter Justin D. , Hutter Cedric A.J. , Garaeva Alisa A. , Scherer Melanie , Zimmermann Iwan , Wyss Marianne , Rheinberger Jan , Ruedin Yelena , Earp Jennifer C. , Egloff Pascal , Sorgenfrei Michèle , Hürlimann Lea M. , Gonda Imre , Meier Gianmarco , Remm Sille , Thavarasah Sujani , van Geest Gerrit , Bruggman Rémy , Zimmer Gert , Slotboom Dirk J. , Paulino Cristina , Plattet Philippe , Seeger Markus A. 
Published: November 2020

ABSTRACTThe ongoing COVID-19 pandemic represents an unprecedented global health crisis. Here, we report the identification of a synthetic nanobody (sybody) pair (Sb#15 and Sb#68) that can bind simultaneously to the SARS-CoV-2 spike-RBD and efficiently neutralize pseudotyped and live-viruses by interfering with ACE2 interaction. Two spatially-discrete epitopes identified by cryo-EM translated into the rational design of bispecific and tri-bispecific fusions constructs, exhibiting up to 100- and 1000-fold increase in neutralization potency. Cryo-EM of the sybody-spike complex further revealed a novelup-outRBD conformation. While resistant viruses emerged rapidly in the presence of single binders, no escape variants were observed in presence of the bispecific sybody. The multivalent bispecific constructs further increased the neutralization potency against globally-circulating SARS- CoV-2 variants of concern. Our study illustrates the power of multivalency and biparatopic nanobody fusions for the development of clinically relevant therapeutic strategies that mitigate the emergence of new SARS-CoV-2 escape mutants.
Genetic and Immunological Evidence for Microbial Transfer Between the International Space Station and an Astronaut
Authors: Danko David C. , Singh Nitin , Butler Daniel J. , Mozsary Christopher , Jiang Peng , Keshavarzian Ali , Maienschein-Cline Mark , Chlipala George , Afshinnekoo Ebrahim , Bezdan Daniela , Garrett-Bakelman Francine , Green Stefan J. , Turek Fred W. , Vitaterna Martha Hotz , Venkateswaran Kasthuri , Mason Christopher E. 
Published: November 2020

AbstractMicrobial transfer from the environment can influence a person’s health, but relevant studies often have confounding variables and short durations. Here, we used the unique environment of the International Space Station (ISS) to track movement of microbes between an astronaut’s commensal microbiomes and their environment. We identified several microbial taxa, includingSerratia proteamaculansandRickettsia australiswhich appear to have been transferred from the ISS to the commensal microbiomes of the astronaut. Strains were matched at the SNP and haplotype-level, and notably some strains persisted even after the astronaut’s return to Earth. Some transferred taxa correspond to secondary strains in the ISS environment, suggesting that transfer may be mediated by evolutionary selection. Finally, we show evidence that the T-Cell repertoire of the astronaut changes to become more specific to environmental taxa, suggesting that continual microbial and immune monitoring can help guide spaceflight mission planning, health monitoring, and habitat design.
The first bismuth borate oxyiodide, Bi4BO7I: commensurate or incommensurate?
Authors: Volkov Sergey , Bubnova Rimma , Krzhizhanovskaya Maria , Galafutnik Lydia 
Published: November 2020

The first bismuth borate oxyiodide, Bi4BO7I, has been prepared by solid-state reaction in evacuated silica ampoules. Its crystal structure [space groupImmm(00γ)000] comprises litharge-related layers of edge-sharing OBi4tetrahedra; the interlayer space is filled by I−and [BO3]3−anions. The wavevector,q = 0.242 (3)c*, is very close to the rational value ofc*/4, yet refinement based on commensurate modulation faces serious problems indicating the incommensurate nature of the modulation. The I-/[BO3]3−anions are ordered in a complex sequence along [001],i.e.–<–BO3–BO3–I–I–>n = 28–I–I–I–<–BO3–BO3–I–I–>n = 28–BO3–BO3–BO3–, leading to a structural modulation. The principal feature of the latter is the presence of –I–I–I– and –BO3–BO3–BO3– sequences that cannot be accounted for in thea ×b × 4csupercell. The thermal expansion of Bi4BO7I is weakly anisotropic (αa = 8,αb = 15 andαc = 17 × 10−6 K−1at 500 K) which is caused by preferential orientation of the borate groups.
A co-occurring disorders intervention for drug treatment court: 12-month pilot study outcomes
Authors: Smelson David , Shaffer Paige M. , Posada Rodriguez Camilo , Gaba Ayorkor , Harter Jennifer , Pinals Debra A. , Casey Sheila C. 
Published: November 2020

PurposeMany individuals in drug treatment courts (DTCs) have co-occurring mental health and substance use disorders (COD), which can negatively impact treatment engagement, behavioral health and criminal justice outcomes. This paper aims to report results of DTC participants with a COD, who received a 12-month wraparound treatment intervention called MISSION-Criminal Justice (MISSION-CJ) alongside DTC to improve treatment engagement and behavioral health outcomes and reduce reincarcerations.Design/methodology/approachIn this pre-post, single-group pilot, 48 clients enrolled and 81% completed 12-month follow-up assessments (N = 39) and weekly MISSION-CJ fidelity for type and intensity of services delivered. Generalized linear mixed models (GLMMs) were computed with a fixed term for fidelity (e.g. high or low MISSION-CJ), time and a fidelity x time interaction term.FindingsAmong participants, at 12 months, 81% of the participants remained engaged in treatment at study completion, and 89% had high MISSON-CJ fidelity. Clients demonstrated significant reductions from baseline to 12 months in average nights in jail (B = −0.1849511, p < 0.0344), mental health symptoms via the Behavior and Symptom Identification Scale (BASIS) total and subscale scores (B = −0.121613,p< 0.0186) and trauma symptoms on the PTSD Checklist-5 (PCL-5) (B = −0.928791, p < 0.0138). High MISSION-CJ fidelity further improved criminal justice, and behavioral health outcomes.Originality/valueThis was the first reported 12-month MISSION-CJ trial. While feasible to implement, given the design limitations, future research should include a large randomized controlled trial.
An error-propagation aware method to reduce the software mutation cost using genetic algorithm
Authors: Mohammad Javad Hosseini Seyed , Arasteh Bahman , Isazadeh Ayaz , Mohsenzadeh Mehran , Mirzarezaee Mitra 
Published: November 2020

PurposeThe purpose of this study is to reduce the number of mutations and, consequently, reduce the cost of mutation test. The results of related studies indicate that about 40% of injected faults (mutants) in the source code are effect-less (equivalent). Equivalent mutants are one of the major costs of mutation testing and the identification of equivalent and effect-less mutants has been known as an undecidable problem.Design/methodology/approachIn a program with n branch instructions (if instruction) there are 2n execution paths (test paths) that the data and codes into each of these paths can be considered as a target of mutation. Given the role and impact of data in a program, some of data and codes propagates the injected mutants more likely to the output of the program. In this study, firstly the error-propagation rate of the program data is quantified using static analysis of the program control-flow graph. Then, the most error-propagating test paths are identified by the proposed heuristic algorithm (Genetic Algorithm [GA]). Data and codes with higher error-propagation rate are only considered as the strategic locations for the mutation testing.FindingsIn order to evaluate the proposed method, an extensive series of mutation testing experiments have been conducted on a set of traditional benchmark programs using MuJava tool set. The results depict that the proposed method reduces the number of mutants about 24%. Also, in the corresponding experiments, the mutation score is increased about 5.6%. The success rate of the GA in finding the most error-propagating paths of the input programs is 99%. On average, only 7.46% of generated mutants by the proposed method are equivalent. Indeed, 92.54% of generated mutants are non-equivalent.Originality/valueThe main contribution of this study is as follows: Proposing a set of equations to measure the error-propagation rate of each data, basic-block and execution path of a program. Proposing a genetic algorithm to identify a most error-propagating path of program as locations of mutations. Developing an efficient mutation-testing framework that mutates only the strategic locations of a program identified by the proposed genetic algorithms. Reducing the time and cost of mutation testing by reducing the equivalent mutants.
Remembering and forgetting the arts of technical education
Authors: Pardy John 
Published: November 2020

PurposeTechnical education in the twentieth century played an important role in the cultural life of Australia in ways are that routinely overlooked or forgotten. As all education is central to the cultural life of any nation this article traces the relationship between technical education and the national social imaginary. Specifically, the article focuses on the connection between art and technical education and does so by considering changing cultural representations of Australia.Design/methodology/approachDrawing upon materials, that include school archives, an unpublished autobiography monograph, art catalogues and documentary film, the article details the lives and works of two artists, from different eras of twentieth century Australia. Utilising social memory as theorised by Connerton (1989, 2009, 2011), the article reflects on the lives of two Australian artists as examples of, and a way into appreciating, the enduring relationship between technical education and art.FindingsThe two artists, William Wallace Anderson and Carol Jerrems both products of, and teachers in, technical schools produced their own art that offered different insights into changes in Australia's national imaginary. By exploring their lives and work, the connections between technical education and art represent a social memory made material in the works of the artists and their representations of Australia's changing national imaginary.Originality/valueThis article features two artist teachers from technical schools as examples of the centrality of art to technical education. Through the teacher-artists lives and works the article highlights a shift in the Australian cultural imaginary at the same time as remembering the centrality of art to technical education. Through the twentieth century the relationship between art and technical education persisted, revealing the sensibilities of the times.
A socio-technical system approach to knowledge creation and team performance: evidence from China
Authors: Cao Xiongfei , Ali Ahsan , Pitafi Abdul Hameed , Khan Ali Nawaz , Waqas Muhammad 
Published: November 2020

PurposeThe purpose of this study is to extend the existing literature on knowledge management, which generally focuses on knowledge sharing. The model of this article explains how knowledge creation and team performance can be increased through the integration of social and technological factorsDesign/methodology/approachTo empirically test the model, multi-wave and multi-source data were collected from 80 teams whose members use social media as a tool for communication and interaction.FindingsThe analysis results provide insights into some interesting findings. The results show transactive memory system (TMS) as an important factor that can significantly contribute to knowledge creation in teams. Especially, the TMS strengthens the significant positive effect of enterprise social media (ESM) and insignificant positive effect of knowledge complementarity on knowledge creation. Furthermore, knowledge creation is found to be a significant predictor of team performanceOriginality/valueMuch of the knowledge management literature focuses on the ways to increase the quantity of accessible knowledge to organization members. Such knowledge management studies are more relevant to knowledge exchange among individual employees, teams and organizations. However, this study takes a nuanced approach to explore how knowledge creation can be increased in teams by implementing a knowledge integration mechanism. A general model of knowledge creation is proposed, but the strength of this model lies in the moderating effect of TMS which strengthens the effect of knowledge complementarity and ESM on knowledge creation in teams which eventually increases team performance.
International capital flows in club of convergence
Authors: Hung Ly Dai , Nguyen Thi Thuy Hoan 
Published: November 2020

PurposeThe paper analyzes the pattern of international capital flows, accounting for the convergence on economic growth.Design/methodology/approachThe paper employs an empirical analysis combined with a theoretical model. The evidence is based on a cross-section regression over a sample of 172 economies. And the model is an open multi-country overlapping generation (OLG) economy.FindingsThe empirical evidence records that the pattern of international capital flows in the club of convergence can diverge from the pattern in the club of unconvergence. A higher productivity growth rate is associated with more net capital inflows in the club of convergence but less net capital inflows in the club of unconvergence. The theory shows that proximity to world technology frontier can explain the divergence of capital flows.Research limitations/implicationsThe result can account for controversies between theories on the cross-border capital flows: allocation puzzle, up-hill capital flows and neoclassical growth model.Originality/valueThe paper combines both the empirical analysis with the theoretical model construction to account for the role of convergence of economic growth on determining the pattern of international capital flows.
Innovation orientation and performance of Kuwaiti family businesses: evidence from the initial period of COVID-19 pandemic
Authors: Zainal Mohammad 
Published: November 2020

PurposeThis paper analyses the impact of innovation orientation on the family business performance in Kuwait. Further, the aim of this paper is to understand the innovation culture among Kuwaiti family businesses and the innovation orientation concept and its importance for these businesses.Design/methodology/approachThe study will use a quantitative research methodology in order to investigate the relationship between independent variables: creativity, risk-taking, future orientation, openness to change and proactiveness with Kuwaiti business performance as a dependent variable. A well-structured questionnaire is distributed to 150 family businesses that operate in Kuwait, where 114 of the respondents responded positively. Structural equation modeling (SEM) analysis was used for evaluating the proposed model.FindingsThe results show that creativity, risk-taking and future orientation have significant relationship with business performance, while openness to change and proactiveness do not have any significant relationship with business performance.Research limitations/implicationsThis research is conducted during the period of initial months of COVID-19 pandemic, March–July 2020 respectively, and responses might be influenced by the current situation.Originality/valueThe correlation between family businesses and innovation orientation is not studied so far in Kuwait. There is a lack of studies about family business in general in Kuwait since there are only very few research studies. This is the first research about this topic that covers Kuwait as a country.
What is bullying hiding? Exploring antecedents and potential dimension of knowledge hiding
Authors: Yuan Yunyun , Yang Lifeng , Cheng Xiangyang , Wei Jia 
Published: November 2020

PurposeThe purpose of this study is to examine the relationships among knowledge attributes (complexity and implicitness), interpersonal distrust, knowledge hiding (KH) and team efficacy and second, to explore a new dimension of KH.Design/methodology/approachData for this research were collected from more than 940 employees working in manufacturing, information technology (IT), finance and the purification industry. Structural equation modeling was used to test hypothesized relationships.FindingsFirst, the research confirmed the existence of bullying hiding behaviors in the knowledge economy era based on “knowledge power.” Second, the findings suggest that knowledge attributes are an important predictor of KH behaviors in organizations. The findings implicate the mediating effect of interpersonal distrust and the moderating role of team efficacy, while team efficacy negatively moderated the relationships between interpersonal distrust with evasive hiding and playing dumb, but positively moderated the relationship between interpersonal distrust with rationalized hiding and bullying hiding.Originality/valueThis is the first study to propose bullying hiding, a behavior that has emerged in organizational knowledge transfer, and it is more detrimental to knowledge sharing than other KH behaviors. The results of research on the different regulating effects of team efficacy on KH behaviors enrich the boundary conditions of KH research.
Does procedural justice climate increase the identification and engagement of migrant workers? A group engagement model perspective
Authors: Adamovic Mladen , Gahan Peter , Olsen Jesse , Harley Bill , Healy Joshua , Theilacker Max 
Published: November 2020

PurposeMigrant workers often suffer from social exclusion in the workplace and therefore identify less with their organization and engage less with their work. To address this issue, the authors integrate research on migrant workers with research on the group engagement model to create a model for understanding and enhancing migrant worker engagement. This allows us to provide insight into how organizations can design their human resource management systems and practices to increase the work engagement of migrant workers.Design/methodology/approachThe authors conducted a survey study with over 4,000 employees from more than 500 workplaces in Australia to test the model.FindingsThe results of the multilevel analysis indicate that a procedurally fair work environment increases organizational identification, which in turn is associated with higher work engagement. The results also indicate that procedural justice climate is more important for migrant workers and increases their organizational identification and engagement.Originality/valueTo increase work engagement of migrant workers, organizations can establish a procedurally fair work environment in which cultural minorities experience unbiased policies and procedures, are able to express their opinions and participate in decision-making.
Management accounting use in micro and small enterprises
Authors: Najera Ruiz Tonatiuh , Collazzo Pablo 
Published: November 2020

Purpose
The purpose of this paper is to explore if and how micro and small firms apply management accounting (MA) techniques.

Design/methodology/approach
The study is based on 36 semistructured interviews with micro and small firm owners/managers in Mexico. Content analysis is used to identify how these enterprises use MA tools.

Findings
Micro and small firms consistently use MA tools. Most of them have some sort of planning, set objectives, have a costing system – even if budgeting is unusual – and use one or two metrics to monitor performance.

Research limitations/implications
This is exploratory research with a limited and nonrandom sample. Only a limited number of MA tools were studied.

Practical implications
Micro and small firms’ use of MA tools. This is arguably important because these enterprises use these techniques in a way that is different from the traditional approach used in bigger corporations. A relevant implication emerging from the findings, as a contribution to practice would be the need to include MA for micro and small businesses in formal training and textbooks.

Originality/value
On top of providing and assessing empirical evidence on a debate that has been so far largely theoretical, and on the back of the relative weight of micro and small enterprises in any given economy, this paper aims at reinforcing awareness on the need to further the study of the decision-making process in such firms.
Implementing evidence-based practice: the challenge of delivering what works for people with learning disabilities at risk of behaviours that challenge
Authors: Denne Louise D. , Gore Nick J. , Hughes J. Carl , Toogood Sandy , Jones Edwin , Brown Freddy Jackson 
Published: November 2020

PurposeThere is an apparent disconnect between the understanding of best practice and service delivery in the support of people with learning disabilities at risk of behaviours that challenge. We suggest, is a problem of implementation. The purpose of this paper is to explore reasons why this might be the case: a failure to recognise the collective works of successive generations of research and practice; and a failure to address the macro-systems involved and systems changes needed to support implementation.Design/methodology/approachThis paper reviews the consensus that exists in respect of best practice. Drawing upon ideas from implementation science the paper highlights the complexities involved in the implementation of all evidence-based practices and uses this as a framework to propose ways in which an infrastructure that facilitates the delivery of services in the learning disabilities field might be built.FindingsThis paper highlights core recommended practices that have been consistent over time and across sources and identifies the systems involved in the implementation process. This paper demonstrates that many of the necessary building blocks of implementation already exist and suggests areas that are yet to be addressed. Critically, the paper highlights the importance of, and the part that all systems need to play in the process.Originality/valueIn the absence of any generalised implementation frameworks of evidence-based practice in the learning disabilities field, the paper suggests that the findings may provide the basis for understanding how the gap that exists between best practice and service delivery in the support of people with a learning disability at risk of behaviours that challenge might be closed.