bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recognising Children’s Citizenship in the Social Care System
Authors: Cockburn Tom , Devine Dympna 
Published: November 2019

AbstractSocial work understanding of children’s citizenship has received little analysis and traditional models tend to view children as passive recipients of care or welfare, rather than as active meaning makers. This is particularly so for looked after children. In contrast, we draw upon the work of Pierre Bourdieu to develop a model of understanding children’s citizenship that on the one hand accounts for the structural flow of governance from modern welfare states that shape children’s lives, while recognising the agency and capacity for action among children. This article applies the model to those in the care system. To capture the everyday agency of children, we build upon Bourdieu’s notion of habitus with ideas of lived citizenship, as defined by Delanty and Lister, and recognition theory classically outlined by Honneth. Furthermore, we contribute to the existing work on habitus to develop a model adapted from the pragmatism associated with the work of Boltanski. In so doing, analysing the critical and justificatory account making of children themselves, social workers are able to engage positively with all children by drawing on a variety of their social worlds.
Between Majority and Minority: A Model for Understanding and Promoting Culturally Competent Policy Practice in Multicultural Societies
Authors: Nouman Hani 
Published: November 2019

AbstractThe engagement of social workers in policy-shaping processes reflects the commitment of the social work profession to promoting equality and social justice. Whilst in many countries engagement is a professional requirement, one cannot ignore the fact that it is essentially a political activity inextricably linked to the socio-political context in which it occurs. Cultural competence for engagement in shaping policy processes is necessary to promote effective engagement of social workers in policy practice in cross-cultural political situations. Notwithstanding the focus of the literature on cultural competence in the past decade, it centres mainly on the intercultural encounter between social workers and clients and on the therapeutic context, with emphasis on the practitioner belonging to the dominant Western culture whilst the client belongs to the less dominant ‘other’ in society. This article attempts to fill the gap by developing a theoretical culturally competent policy practice model to examine different dimensions of cultural competence required for the engagement of social workers from different ethnic groups in the policy arena. In addition, the article presents the significant implications of the model for policy, practice and research.
Early detection of rapid Barred Owl population growth within the range of the California Spotted Owl advises the Precautionary Principle
Authors: Wood Connor M , Gutiérrez R J , Keane John J , Peery M Zachariah 
Published: November 2019

Abstract
Biological invasions are most practical to manage when invasive species population densities are low. Despite a potentially narrow window of opportunity for efficient management, managers tend to delay intervention because the cost of prompt action is often high and resources are limited. The Barred Owl (Strix varia) invaded and colonized the entire range of the Northern Spotted Owl (S. occidentalis caurina), but insufficient population data contributed to delays in action until the Barred Owl posed an existential threat to the Spotted Owl. The leading edge of the Barred Owl expansion has since reached the Sierra Nevada, the core range of the California Spotted Owl (S. o. occidentalis). We conducted passive acoustic surveys within 400-ha grid cells across ~6,200 km2 in the northern Sierra Nevada and detected a 2.6-fold increase in Barred Owl site occupancy between 2017 and 2018, from 0.082 (85% confidence interval: 0.045–0.12) to 0.21 (0.14–0.28). The probability of Barred Owl site colonization increased with the amount of older forest, suggesting that Barred Owls are first occupying the preferred habitat of Spotted Owls. GPS-tagged Barred Owls (n = 10) generally displayed seasonal and interannual site fidelity over territories averaging 411 ha (range: 150–513 ha), suggesting that our occupancy estimates were not substantially upwardly biased by “double counting” individuals whose territories spanned multiple grid cells. Given the Barred Owl’s demonstrated threat to the Northern Spotted Owl, we believe our findings advise the Precautionary Principle, which posits that management actions such as invasive species removal should be taken despite uncertainties about, for example, true rates of population growth if the cost of inaction is high. In this case, initiating Barred Owl removals in the Sierra Nevada before the population grows further will likely make such action more cost-effective and more humane than if it is delayed. It could also prevent the extirpation of the California Spotted Owl from its core range.
Ligation of the Intersphincteric Fistula Tract and Endorectal Advancement Flap for High Perianal Fistulas in Crohn’s Disease: A Retrospective Cohort Study
Authors: van Praag Elise M , Stellingwerf Merel E , van der Bilt Jarmila D W , Bemelman Wilhelmus A , Gecse Krisztina B , Buskens Christianne J 
Published: November 2019

AbstractBackground and AimsLigation of the intersphincteric fistula tract [LIFT] and advancement flap [AF] procedures are well-established, sphincter-preserving procedures for closure of high perianal fistulas. As surgical fistula closure is not commonly offered in Crohn’s disease patients, long-term data are limited. This study aims to evaluate outcomes after LIFT and AF in Crohn’s high perianal fistulas.MethodsAll consecutive Crohn’s disease patients ≥18 years old treated with LIFT or AF between January 2007 and February 2018 were included. The primary outcome was clinical healing and secondary outcomes included radiological healing, recurrence, postoperative incontinence and Vaizey Incontinence Score.ResultsForty procedures in 37 patients [LIFT: 19, AF: 21, 35.1% male] were included. A non-significant trend was seen towards higher clinical healing percentages after LIFT compared to AF [89.5% vs 60.0%; p = 0.065]. Overall radiological healing rates were lower for both approaches [LIFT 52.6% and AF 47.6%]. Recurrence rates were comparable: 21.1% and 19.0%, respectively. In AF a trend was seen towards higher clinical healing percentages when treated with anti-tumour necrosis factor/immunomodulators [75.0% vs 37.5%; p = 0.104]. Newly developed postoperative incontinence occurred in 15.8% after LIFT and 21.4% after AF. Interestingly, 47.4% of patients had a postoperatively improved Vaizey Score [LIFT: 52.9% and AF: 42.9%]. The mean Vaizey Score decreased from 6.8 [SD 4.8] preoperatively to 5.3 [SD 5.0] postoperatively [p = 0.067].ConclusionsBoth LIFT and AF resulted in satisfactory closure rates in Crohn’s high perianal fistulas. However, a discrepancy between clinical and radiological healing rates was found. Furthermore, almost half of the patients benefitted from surgical intervention with respect to continence.
Modulation of CD39 and Exogenous APT102 Correct Immune Dysfunction in Experimental Colitis and Crohn’s Disease
Authors: Robles René J , Mukherjee Samiran , Vuerich Marta , Xie Anyan , Harshe Rasika , Cowan Peter J , Csizmadia Eva , Wu Yan , Moss Alan C , Chen Ridong , Robson Simon C , Longhi Maria Serena 
Published: November 2019

Abstract

Background and Aims
CD39/ENTPD1 scavenges pro-inflammatory nucleotides, to ultimately generate immunosuppressive adenosine, which has a central role in immune homeostasis. Global deletion of Cd39 increases susceptibility to experimental colitis while single nucleotide polymorphisms within the human CD39 promoter, and aberrant patterns of expression during experimental hypoxia, predispose to Crohn’s disease. We aimed to define the impact of transgenic human CD39 [hTG] overexpression in experimental colitis and to model therapeutic effects using the recombinant apyrase APT102 in vivo. We also determined the in vitro effects of APT102 on phenotypic and functional properties of regulatory T-lymphocytes derived from patients with Crohn’s disease.

Methods
Colitis was induced by administration of dextran sulfate sodium in wild-type [WT] or hTG mice, and, in another model, by adoptive transfer of CD45RBhigh cells with or without WT or hTG regulatory T cells [Treg]. In additional experiments, mice were treated with APT102. The effects of APT102 on phenotype and function of Treg and type-1 regulatory T [Tr1] cells were also evaluated, after purification from peripheral blood and lamina propria of Crohn’s disease patients [n = 38].

Results
Overexpression of human CD39 attenuated experimental colitis and protected from the deleterious effects of systemic hypoxia, pharmacologically induced by deferoxamine. Administration of APT102 in vivo enhanced the beneficial effects of endogenous Cd39 boosted by the administration of the aryl hydrocarbon receptor [AhR] ligand unconjugated bilirubin [UCB]. Importantly, supplemental APT102 restored responsiveness to AhR stimulation by UCB in Treg and Tr1 cells, obtained from Crohn’s disease patients.

Conclusions
hCD39 overexpression ameliorated experimental colitis and prevented hypoxia-related damage in vivo. Exogenous administration of APT102 boosted AhR-mediated regulatory effects in vivo while enhancing Treg functions in Crohn’s disease in vitro.
Patient trends and outcomes of surgery for type A acute aortic dissection in Japan: an analysis of more than 10 000 patients from the Japan Cardiovascular Surgery Database
Authors: Abe Tomonobu , Yamamoto Hiroyuki , Miyata Hiroaki , Motomura Noboru , Tokuda Yoshiyuki , Tanemoto Kazuo , Usui Akihiro , Takamoto Shinichi 
Published: November 2019

Abstract

OBJECTIVES
To evaluate the background trends and surgical outcomes for more than 10 000 patients with acute type A dissection in Japan in a recent 8-year period.

METHODS
Data on replacement of the ascending aorta and/or aortic arch for acute type A dissection were collected from the Japan Cardiovascular Surgery Database from 2008 to 2015. Linear-by-linear association tests or Cuzick’s test for trend was used to evaluate group trends over time. The results were calculated for ascending or hemiarch replacement and arch replacement. A multivariable logistic regression model was used to calculate the risk-adjusted operative mortality rate.

RESULTS
A total of 11 843 patients were included. The overall 30-day mortality and operative mortality rates were 7.6% and 9.5%, respectively. The number of surgically treated cases increased from 2436 patients in 2008–2009 to 3533 in 2014–2015, a 45.0% increase. A trend analysis revealed significant changes in patient characteristics with time, including increasing age and rate of preoperative renal failure. Despite worsening risk factors, the unadjusted operative mortality rate with arch replacement showed a significant downward trend (P = 0.01; test of trend). The risk-adjusted mortality rate showed a downward trend both in ascending aorta or hemiarch replacement and arch replacement, although the trend was not statistically significant (P &gt; 0.05).

CONCLUSIONS
Unadjusted and adjusted operative deaths have shown a decreasing trend, although patients undergoing surgery for acute type A dissection have demonstrated worsening of risk factors, such as age and renal failure. The number of surgeries performed for acute type A dissection significantly increased throughout the study period in Japan.
Convergent Evolution of Claw Shape in a Transcontinental Lizard Radiation
Authors: Baeckens Simon , Goeyers Charlotte , Van Damme Raoul 
Published: November 2019

AbstractSpecies occupying similar selective environments often share similar phenotypes as the result of natural selection. Recent discoveries, however, have led to the understanding that phenotypes may also converge for other reasons than recurring selection. We argue that the vertebrate claw system constitutes a promising but understudied model system for testing the adaptive nature of phenotypic, functional, and genetic convergence. In this study, we combine basic morphometrics and advanced techniques in form analysis to examine claw shape divergence in a transcontinental lizard radiation (Lacertidae). We find substantial interspecific variation in claw morphology and phylogenetic comparative statistics reveal a strong correlation with structural habitat use: ground-dwelling species living in open areas are equipped with long, thick, weakly curved, slender-bodied claws, whereas climbing species carry high, short, strongly curved, full-bodied claws. Species occupying densely vegetated habitats tend to carry intermediately shaped claws. Evolutionary models suggest that claw shape evolves toward multiple adaptive peaks, with structural habitat use pulling species toward a specific selective optimum. Contrary to findings in several other vertebrate taxa, our analyses indicate that environmental pressures, not phylogenetic relatedness, drive convergent evolution of similarly shaped claws in lacertids. Overall, our study suggests that lacertids independently evolved similarly shaped claws as an adaptation to similar structural environments in order to cope with the specific locomotory challenges posed by the habitat. Future biomechanical studies that link form and function in combination with genomic and development research will prove valuable in better understanding the adaptive significance of claw shape divergence.
Phase harmonic correlations and convolutional neural networks
Authors: Mallat Stéphane , Zhang Sixin , Rochette Gaspar 
Published: November 2019

Abstract
A major issue in harmonic analysis is to capture the phase dependence of frequency representations, which carries important signal properties. It seems that convolutional neural networks have found a way. Over time-series and images, convolutional networks often learn a first layer of filters that are well localized in the frequency domain, with different phases. We show that a rectifier then acts as a filter on the phase of the resulting coefficients. It computes signal descriptors that are local in space, frequency and phase. The nonlinear phase filter becomes a multiplicative operator over phase harmonics computed with a Fourier transform along the phase. We prove that it defines a bi-Lipschitz and invertible representation. The correlations of phase harmonics coefficients characterize coherent structures from their phase dependence across frequencies. For wavelet filters, we show numerically that signals having sparse wavelet coefficients can be recovered from few phase harmonic correlations, which provide a compressive representation.
Reduced Cardiac Index Reserve and Hypovolemia in Severe Falciparum Malaria
Authors: Kingston Hugh W F , Ghose Aniruddha , Rungpradubvong Voravut , Satitthummanid Sudarat , Herdman M Trent , Plewes Katherine , Leopold Stije J , Ishioka Haruhiko , Mohanty Sanjib , Maude Richard J , Schultz Marcus J , Lagrand Wim K , Hossain Md Amir , Day Nicholas P J , White Nicholas J , Anstey Nicholas M , Dondorp Arjen M 
Published: November 2019

Abstract

Background
Impaired microvascular perfusion is central to the development of coma and lactic acidosis in severe falciparum malaria. Refractory hypotension is rare on admission but develops frequently in fatal cases. We assessed cardiac function and volume status in severe falciparum malaria and its prognostic significance.

Methods
Patients with severe (N = 101) or acute uncomplicated falciparum malaria (N = 83) were recruited from 2 hospitals in India and Bangladesh, and healthy participants (N = 44) underwent echocardiography.

Results
Patients with severe malaria had 38% shorter left ventricular (LV) filling times and 25% shorter LV ejection times than healthy participants because of tachycardia; however, stroke volume, LV internal diameter in diastole (LVIDd), and LV internal diameter in systole (LVIDs) indices were similar. A low endocardial fraction shortening (eFS) was present in 17% (9 of 52) of severe malaria patients. Adjusting for preload and afterload, eFS was similar in health and severe malaria. Fatal cases had smaller baseline LVIDd and LVIDs indices, more collapsible inferior vena cavae (IVC), and higher heart rates than survivors. The LVIDs and IVC collapsibility were independent predictors for mortality, together with base excess and Glasgow Coma Scale.

Conclusions
Patients with severe malaria have rapid ejection of a normal stroke volume. Fatal cases had features of relative hypovolemia and reduced cardiac index reserve.
Towards Rapid Sepsis Diagnosis and Patients Stratification: What’s New From Microbiology and Omics Science
Authors: Mangioni Davide , Peri Anna Maria , Rossolini Gian Maria , Viaggi Bruno , Perno Carlo Federico , Gori Andrea , Bandera Alessandra 
Published: November 2019

Abstract
Early etiological diagnosis and characterization of host response to infection are becoming central in sepsis recognition and management. Still, limitations in conventional diagnosis and patient stratification contribute to the high mortality rates of septic patients despite new antimicrobials and resuscitation agents. Novel microbiological techniques and omics analyses have recently led to the development of several tests that are now commercially available or in the pipeline as rapid diagnostic tools. In this review, we first summarize emerging assays for the etiological diagnosis starting directly from whole blood, based on target-specific PCRs or metagenomics. We then investigate results of different omics approaches for both bedside diagnosis of immune dysfunction and detection of patients’ signatures associated with different clinical outcomes or potential response to individualized therapies. Finally, we discuss about the translation of these novel laboratory tools into clinical practice, showing how their best performance is achieved when integrated within antimicrobial stewardship programs.
Measles Outbreak in a High-Income Country: Are Pediatricians Ready?
Authors: Lo Vecchio Andrea , Montagnani Carlotta , Krzysztofiak Andrzej , Valentini Piero , Rossi Nadia , Bozzola Elena , Castelli Gattinara Guido , Magurano Fabio , Guarino Alfredo , Galli Luisa ,   Italian Society for Pediatric Infectious Diseases Measles Study Group, Silvia Garazzino , Irene Raffaldi , Maria Di Gangi , Susanna Esposito , Barbara Vecchi , Luisa Melzi Maria , Marcello Lanari , Giorgio Zavarise , Samantha Bosis , Mariella Valenzise , Salvatore Cazzato , Michele Sacco , Maria Rita Govoni , Elena Mozzo , Maria Donata Cambriglia , Pata Davide , Graziosi Alessandro , Sala Debora , Baggieri Melissa 
Published: November 2019

AbstractBackgroundMeasles is a highly communicable infection with potentially severe complications. It is rarely reported in high-income countries and the limited awareness and experience of pediatricians may result in misdiagnosis. The present study aimed at investigating physician’s ability and timing to reach diagnosis during a recent outbreak in Italy.MethodsThe Italian Society for Pediatric Infectious Diseases conducted a retrospective, multicenter study in children hospitalized for measles between 1 January 2016 and 30 August 2017 in secondary and tertiary care hospitals. The appropriateness of diagnosis at admission, the time to reach clinical diagnosis, and serological confirmation of measles were recorded.ResultsAt hospital admission, measles was misdiagnosed in 101 (40.5%) of the 249 children (median age, 14.5 months) enrolled. The appropriate diagnosis increased from 30% to 72.5% during the period of observation (P &lt; .001). A greater chance of receiving an appropriate diagnosis was demonstrated in children who reported a contact with measles (odds ratio [OR], 5.2; 95% confidence interval [CI], 3.0–9.2) or in those seen in institutions that managed more cases (OR, 7.39; 95% CI, 3.22–16.9; P = .0001). In contrast, children with underlying chronic conditions had a higher risk of misdiagnosis (appropriate diagnosis OR, 0.19; 95% CI, 0.10–0.33). The mean time from the onset of symptoms to clinical diagnosis was 4.55 ± 2.2 days and to serological confirmation was 7.0 ± 3.4 days.ConclusionsMeasles is frequently misdiagnosed in low-prevalence settings. Specific measures to increase pediatricians’ awareness about vaccine-preventable infections need to be implemented.
Long troughs in the Lyman-α forest below redshift 6 due to islands of neutral hydrogen
Authors: Keating Laura C , Weinberger Lewis H , Kulkarni Girish , Haehnelt Martin G , Chardin Jonathan , Aubert Dominique 
Published: November 2019

ABSTRACT
A long (110 cMpc h−1) and deep absorption trough in the Ly α forest has been observed extending down to redshift 5.5 in the spectrum of ULAS J0148+0600. Although no Ly α transmission is detected, Ly β spikes are present which has led to claims that the gas along this trough must be ionized. Using high-resolution cosmological radiative transfer simulations in large volumes, we show that in a scenario where reionization ends late (z ∼ 5.2), our simulations can reproduce troughs as long as observed. In this model, we find that the troughs are caused by islands of neutral hydrogen. Small ionized holes within the neutral islands allow for the transmission of Ly β. We have also modelled the Ly α emitter population around the simulated troughs, and show that there is a deficit of Ly α emitters close to the trough as is observed.
iPTF14hls as a variable hyper-wind from a very massive star
Authors: Moriya Takashi J , Mazzali Paolo A , Pian Elena 
Published: November 2019

Abstract
The origin of iPTF14hls, which had Type IIP supernova-like spectra but kept bright for almost two years with little spectral evolution, is still unclear. We here propose that iPTF14hls was not a sudden outburst like supernovae but rather a long-term outflow similar to stellar winds. The properties of iPTF14hls, which are at odds with a supernova scenario, become natural when interpreted as a stellar wind with variable mass-loss rate. Based on the wind hypothesis, we estimate the mass-loss rates of iPTF14hls in the bright phase. We find that the instantaneous mass-loss rate of iPTF14hls during the 2-year bright phase was more than a few M⊙ yr−1 (“hyper-wind”) and it reached as much as 10 M⊙ yr−1 . The total mass lost over two years was about 10 M⊙. Interestingly, we find that the light curve of iPTF14hls has a very similar shape to that of η Carinae during the Great Eruption, which also experienced a similar but less extreme brightening accompanied by extraordinary mass loss, shedding more than 10 M⊙ in 10 years. The progenitor of iPTF14hls is less than 150 M⊙ if it still exists, which is similar to η Carinae. The two phenomena may be related to a continuum-driven extreme wind from very massive stars.
What determines the observational magnitudes of Forbush events on Earth: A critique of the traditional manual method
Authors: Okike O 
Published: November 2019

ABSTRACTForbush decreases (FDs) seem to be the compass for researchers searching for Sun–Earth weather relationships. Thus, a wide range of the solar-terrestrial literature is dominated by FD-based analyses. While the results of such investigations are often questioned on the basis of small FD sample sizes, statistical significance tests and inappropriate methodological approaches, the efficiency and the validity of manual FD event selection are yet to be examined in detail. Because the results obtained depend on the Forbush event location on Earth, and on timing and magnitude estimation, this paper emphasizes the need for the correct acquisition of FD data prior to composition or correlation/regression analyses.