bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive value of heart failure with reduced versus preserved ejection fraction for outcome in pulmonary embolism
Authors: Obradovic Slobodan , Dzudovic Boris , Subotic Bojana , Matijasevic Jovan , Mladenovic Zorica , Bokan Aleksandar , Trobok Jadranka , Pekovic Sandra , Salinger‐Martinovic Sonja , Jovanovic Ljiljana , Kos Ljiljana , Kovacevic‐Preradovic Tamara , Nikolic Maja , Miloradovic Vladimir , Kovacevic‐Kuzmanovic Ana , Zec Nenad , Markovic‐Nikolic Natasa , Srdanovic Ilija , Gluvic Zoran , Kafedzic Srdjan , Pancevacki Sasa , Neskovic Aleksandar , Konstantinides Stavros 
Published: September 2020

AbstractAimsThis study aimed to investigate whether the risk of short‐term mortality is different in pulmonary embolism (PE) patients who have heart failure with reduced ejection fraction (HFrEF) as compared with those with heart failure with preserved ejection fraction (HFpEF).Methods and resultsPredictive value of HFrEF or HFpEF for 7‐day (intrahospital) and 30‐day all‐cause mortality was determined in the cohort of 1055 out of 1201 consecutive acute PE patients from the Serbian multicentre PE registry. Patients were classified into either HFrEF or HFpEF group, according to guideline‐proposed criteria. A 7‐day (intrahospital) and 30‐day all‐cause mortality was 18.5% vs. 7.3% vs. 4.5% (P < 0.001) and 22.2% vs. 16.3% vs. 7.9% (P < 0.001) for patients with the history of HFrEF, HFpEF, and without HF, respectively. Multivariable analysis adjusted to age, gender, history of chronic obstructive pulmonary disease, diabetes mellitus, arterial hypertension, presence of atrial fibrillation, and mortality risk assessment at admission has shown that only HFrEF, but not HFpEF, was an independent predictor for 7‐day mortality (hazard ratio 2.22, 95% confidence interval 1.25‐4,38.41, P = 0.021) and neither HFrEF or HFpEF was an independent predictor for 30‐day mortality. Among various admission parameters associated to PE outcome, only systolic pressure in HFrEF patients (P < 0.001), heart rate (P = 0.01), and right ventricle systolic pressure (P = 0.039) in HFpEF patients were significantly different in patients who died compared with those who survived at 7 days.ConclusionsOur study has shown that the presence of previous history of HFrEF, but not HFpEF, in acute PE is an independent risk factor for mortality at 7 days.
Fibroblast‐growth‐factor‐23 in heart failure with preserved ejection fraction: relation to exercise capacity and outcomes
Authors: Kanagala Prathap , Arnold Jayanth R. , Khan Jamal N. , Singh Anvesha , Gulsin Gaurav S. , Eltayeb Mohamed , Gupta Pankaj , Squire Iain B. , McCann Gerry P. , Ng Leong L. 
Published: September 2020

AbstractAimsThis study aimed to assess plasma fibroblast growth factor 23 (FGF23) in patients with heart failure with preserved ejection fraction (HFpEF) and its relation to inflammation, renal function, clinical and imaging characteristics, exercise capacity, and prognosis.Methods and resultsWe performed a prospective, observational study of 172 age‐matched and sex‐matched subjects (HFpEF n = 130; controls n = 42, age 73 ± 9, female 50%) who underwent plasma biomarker sampling, echocardiography, cardiac magnetic resonance imaging, and 6 min walk testing (6MWT). The primary endpoint was the composite of all‐cause death or HF hospitalization. FGF23 was higher in HFpEF compared with controls (62 [42–105] vs. 34 [22–41] pg/mL, P < 0.0001). In HFpEF, FGF23 correlated with greater symptom burden (New York Heart Association class: r = 0.308), poorer exercise capacity (6MWT distance: r = −0.345), and plasma biomarkers reflecting inflammation (highly sensitive C‐reactive protein: r = 0.207, myeloperoxidase: r = 0.311), bone metabolism (osteoprotegerin: r = 0.446), renal dysfunction (urea: r = 0.267, creatinine: r = 0.351, estimated glomerular filtration rate: r = −0.367), and echocardiographic E/e′ (r = 0.298); P < 0.05. Following multivariable linear regression modelling, FGF23 remained independently associated with shorter 6MWT distance (P = 0.012) in addition to age, body mass index, and lower haemoglobin. During follow‐up (median 1428 days), there were 61 composite events (21 deaths, 40 HF hospitalizations) in patients with HFpEF. In multivariable Cox regression analysis, FGF23 [adjusted hazard ratio (HR) 1.665; 95% confidence interval (CI) (1.284–2.160; P < 0.0001)], B‐type natriuretic peptide (HR 1.433; CI 1.053–1.951; P = 0.022), and prior HF hospitalization (HR 2.058; CI 1.074–3.942; P = 0.030) were independent predictors of the composite endpoint.ConclusionsPlasma FGF23 is higher in HFpEF compared with age‐matched and sex‐matched controls and is strongly associated with exercise incapacity and prognosis. FGF23 correlates with plasma markers of inflammation and renal impairment.
Transfer and dissipation of strain energy in surrounding rock of deep roadway considering strain softening and dilatancy
Authors: Yi Kang , Liu Zhenghe , Lu Zhiguo , Zhang Junwen , Sun Zhuoyue 
Published: September 2020

AbstractIn this study, the transfer and dissipation of strain energy in the surrounding rock of a deep roadway were analyzed, considering the objective strain softening and dilatancy behaviors. The strain energy increment was decomposed, and its variation was analyzed based on the incremental plastic flow theory; then, a numerical simulation was conducted for verification and further analysis. The results were verified by the field monitoring data of a coal mine gateway. The results show that in the elastic stage, the volumetric elastic strain energy density Uev decreases, while the shear elastic strain energy density Ues increases. In the plastic stage, both Uev and Ues decrease. The volumetric plastic strain energy density Upv is negative, and its absolute value increases, leading to strain energy accumulation. In contrast, the shear plastic strain energy density Ups is positive and increases, leading to strain energy dissipation. Considering strain softening, the elastic strain energy decreases, the plastic strain energy increases, and the region of strain energy dissipation expands. Considering dilatancy, the plastic strain energy varies more significantly, and the effect of strain softening is amplified. The strain energy is transferred from the deep part to the shallow part of the elastic zone and then to the plastic zone. The preexisting and input strain energies in the plastic zone are transformed into considerable amounts of plastic strain energy and then dissipated. Thereafter, a significant plastic strain appears, leading to the large deformation of the surrounding rock.
Natural levee evolution in vegetated fluvial‐tidal environments
Authors: Boechat Albernaz Marcio , Roelofs Lonneke , Pierik Harm Jan , Kleinhans Maarten G. 
Published: September 2020

AbstractNatural levees are common features in river, delta and tidal landscapes. They are elevated near‐channel morphological features that determine the connection between channel and floodbasin, and consequently affect long‐term evolution up to delta‐scales. Despite their relevance in shaping fluvial‐tidal systems, research on levees is sparse and often limited to fluvial or non‐tidal case studies. There is also a general lack of understanding of the role of vegetation in shaping these geomorphic units, and how levee morphology and dimensions vary in the transition from fluvial to coastal environments, where tides are increasingly important. Our goal is to unravel the effects of fluvial‐tidal boundary conditions, sediment supply and vegetation on levee characteristics and floodbasin evolution. These conditions were systematically explored by 60 large‐scale idealized morphodynamic simulations in Delft3D which self‐developed levees over the course of one century. We compared our results to a global levee dataset compilation of natural levee dimensions. We found that levee height is determined by the maximum water level, provided sufficient levee building sediments are available. Discharge fluctuations increased levee width and triggered more levee breaches, i.e. crevasses, that effectively filled the fluvio‐tidal floodbasin. The presence of wood‐type (sparse) vegetation further increased the number of crevasses in comparison with the non‐vegetated scenarios. Conversely, reed‐type (dense) vegetation strongly dampened tidal amplitude and reduced the accommodation space and sedimentation further into the floodbasin, resulting in narrower levees, no crevasses and limited floodbasin accretion. However, dense vegetation reduced tidal forces which allowed levee growth further downstream. Ultimately, the levees merged with the coastal barrier, eliminating the floodbasin tides entirely. Our results elucidate the mechanisms by which levee and crevasse formation, and vegetation may fill fluvio‐tidal wetlands and affect estuary evolution. This brings new insights for geological reconstructions as well as for the future management of deltas and estuaries under sea‐level rise. © 2020 The Authors. Earth Surface Processes and Landforms published by John Wiley & Sons Ltd
Enhanced dynamic team access control for collaborative Internet of Things using context
Authors: Djilali Hadjer Benhadj , Tandjaoui Djamel , Khemissa Hamza 
Published: September 2020

SummaryThe development of the Internet of Things (IoT) aims to overcome security issues especially in critical areas that require integrity, confidentiality and a high level of privacy of the data. Among security challenges, the access control model should be well defined and adapted to the characteristics and security requirements of IoT applications. The work presented here proposes big enforcement of security for dynamic team access control using context information in order to provide granular and secure authorizations with different access control levels related to collaborative IoT. The enhanced dynamic team access control (EDTMAC) model introduces a formal theoretical model which relies on the top of the role‐based access control model. The use of different context information with a global context information security policy and security rules raised the model strength against unauthorized access and avoided security breaches such as the leak of information by providing the least privileges for the users. The result of EDTMAC analysis shows that the model is well adapted to IoT dynamic nature and collaborative IoT activities for teams. Moreover, the model is flexible and scalable, user‐driven, reliable, and secure against unauthorized access requests. The developed model supports the well‐known least‐privilege principle and separation of duties for the team members. In addition, it allows easy management of the teams, provides fine‐grained access control authorizations and supports delegation.
Over expression of brain and acute leukemia, cytoplasmic and ETS‐related gene is associated with poor outcome in acute myeloid leukemia
Authors: Hasan Syed Khizer , Patkar Nikhil V. , Rajamanickam Deepan , Gokarn Anant , Lucena‐Araujo Antonio R. , Tembhare Prashant , Bagal Bhausaheb , Kadam Amare Pratibha , Jain Hasmukh , Gujral Sumeet , Sengar Manju , Subramanian Papagudi Ganesan , Khattry Navin 
Published: September 2020

AbstractThe high expression of brain and acute leukemia, cytoplasmic (BAALC) and ETS‐related gene (ERG) has been reported to influence the outcome in acute myeloid leukemia (AML), but due to limited prospective studies, their role as prognostic factors is unclear. At diagnosis, the prognostic value of BAALC and ERG expression with respect to other cytogenetic and molecular markers was analyzed in 149 AML patients. Patients were divided into quartiles which resulted in the formation of four groups (G1–G4) based on expression values of BAALC and ERG and clinical response defined across groups. Groups with similar survival probabilities were merged together and categorized subsequently as high versus low expressers. Patients with high BAALC and ERG expression had significantly lower overall survival (OS; BAALC: p = 0.001 at 5 years 29.4% vs. 69.8%; ERG: p < 0.0001 at 5 years 4% vs. 50.4%) and disease‐free survival (BAALC: p = 0.001 at 5 years 19.5% vs. 69.8%; ERG: p < 0.0001 at 5 years 4.2% vs. 47%). Patients were further stratified combining BAALC and ERG expression in an integrative prognostic risk score (IPRS). After a median follow‐up of 54 months (95% CI 45–63 months) among survivors, IPRS for high versus low expressers was a significant predictor for OS (BAALC + ERG: 4% vs. 71.6%, p < 0.0001) and DFS (BAALC + ERG: 4.5% vs. 74.1%, p < 0.0001). In a multivariate model, IPRS of BAALC + ERG expression retained prognostic significance for OS (hazard ratio [HR] 2.96, 95%CI 1.91–4.59, p < 0.001) and DFS (HR 3.61, 95%CI 2.26–5.76, p < 0.001).
How do economic policy uncertainties affect stock market volatility? Evidence from G7 countries
Authors: Ma Yaming , Wang Ziwei , He Feng 
Published: September 2020

AbstractThis study explores the dynamic and frequency spillover characteristics between economic policy uncertainty (EPU) and stock market realized volatility (RV) in G7 countries. We apply the monthly data of country‐specific economic policy uncertainty indices and realized volatility to calculate the directional spillover indicator. Then we use a Fourier transformation to calculate the frequency of spillovers to study the duration of the spillover effect. We find that the spillover effect of EPU on stock market volatility is relatively large in the U.S., Japan and Canada, and has certain regional similarities. EPU has longer spillover effects on the stock markets of France, Germany and Italy, which is strongest over 3–18 months. Finally, important economic events such as the financial crisis and the Brexit, increased EPU spillover level and lasting time. We provide the dynamic and frequency spillover characteristics between EPU and the stock market in G7 countries, making this study useful for international asset allocation and risk management.
Seeing the mind of robots: Harm augments mind perception but benevolent intentions reduce dehumanisation of artificial entities in visual vignettes
Authors: Küster Dennis , Swiderska Aleksandra 
Published: September 2020

According to moral typecasting theory, good‐ and evil‐doers (agents) interact with the recipients of their actions (patients) in a moral dyad. When this dyad is completed, mind attribution towards intentionally harmed liminal minds is enhanced. However, from a dehumanisation view, malevolent actions may instead result in a denial of humanness. To contrast both accounts, a visual vignette experiment (N = 253) depicted either malevolent or benevolent intentions towards robotic or human avatars. Additionally, we examined the role of harm‐salience by showing patients as either harmed, or still unharmed. The results revealed significantly increased mind attribution towards visibly harmed patients, mediated by perceived pain and expressed empathy. Benevolent and malevolent intentions were evaluated respectively as morally right or wrong, but their impact on the patient was diminished for the robotic avatar. Contrary to dehumanisation predictions, our manipulation of intentions failed to affect mind perception. Nonetheless, benevolent intentions reduced dehumanisation of the patients. Moreover, when pain and empathy were statistically controlled, the effect of intentions on mind perception was mediated by dehumanisation. These findings suggest that perceived intentions might only be indirectly tied to mind perception, and that their role may be better understood when additionally accounting for empathy and dehumanisation.
Electronic structures of NbGen−/0/+ (n = 1–3) clusters from multiconfigurational CASPT2 and density matrix renormalization group‐CASPT2 calculations
Authors: Tran Van Tan , Tran Quoc Tri 
Published: September 2020

AbstractDensity functional theory and multiconfigurational CASPT2 and density matrix renormalization group DMRG‐CASPT2 have been employed to study the low‐lying states of NbGen−/0/+ (n = 1–3) clusters. With the DMRG‐CASPT2 method, the active spaces are extended to a size of 20 orbitals. For most of the states, the CASPT2 relative energies are comparable with the DMRG‐CASPT2 results. The leading configuration, bond distances, vibrational frequencies, and relative energies of the low‐lying states of these clusters were calculated. The ground states of these clusters were computed to be 3Δ, 4Φ, and 5Φ of NbGe−/0/+; 3A2, 4B1, and 3B1 of cyclic‐NbGe2−/0/+; and 1A′, 12A″ and 12A′′ (2E), and 3A″ of tetrahedral‐NbGe3−/0/+ isomers. For NbGe cluster, our calculations proposed that the 6∑ is almost degenerate with the 4Φ with the CASPT2 and DMRG‐CASPT2 relative energies of 0.05 and 0.06 eV. The adiabatic detachment energies of NbGen− (n = 1–3) clusters were estimated to be 1.46, 1.55, and 2.18 eV by the CASPT2 method. The relevant detachment energies of the anionic ground state and the ionization energies of the neutral ground states are evaluated at the CASPT2 level.
HIV‐1 transmitted drug resistance surveillance: shifting trends in study design and prevalence estimates
Authors: Rhee Soo‐Yon , Kassaye Seble G , Barrow Geoffrey , Sundaramurthi Jagadish Chandrabose , Jordan Michael R , Shafer Robert W 
Published: September 2020

AbstractIntroductionHIV‐1 transmitted drug resistance (TDR) prevalence increased during the initial years of the antiretroviral therapy (ART) global scale‐up. Few studies have examined recent trends in TDR prevalence using published genetic sequences and described the characteristics of ART‐naïve persons from whom these published sequences have been obtained.MethodsWe identified 125 studies published between 2014 and 2019 for which HIV‐1 reverse transcriptase (RT) with or without protease from ≥50 ART‐naïve adult persons were submitted to the GenBank sequence database. The population characteristics and TDR prevalence were compared to those in 122 studies published in the preceding five years between 2009 and 2013. TDR prevalence was analysed using median study‐level and person‐level data.Results and discussionThe 2009 to 2013 and 2014 to 2019 studies reported sequence data from 32,866 and 41,724 ART‐naïve persons respectively. Studies from the low‐ and middle‐income country (LMIC) regions in sub‐Saharan Africa, South/Southeast Asia and Latin America/Caribbean accounted for approximately two‐thirds of the studies during each period. Between the two periods, the proportion of studies from sub‐Saharan Africa and from South/Southeast Asia countries other than China decreased from 43% to 32% and the proportion of studies performed at sentinel sites for recent HIV‐1 infection decreased from 33% to 22%. Between 2014 and 2019, median study‐level TDR prevalence was 4.1% in South/Southeast Asia, 6.0% in sub‐Saharan Africa, 9.1% in Latin America/Caribbean, 8.5% in Europe and 14.2% in North America. In the person‐level analysis, there was an increase in overall, NNRTI and two‐class NRTI/NNRTI resistance in sub‐Saharan Africa; an increase in NNRTI resistance in Latin America/Caribbean, and an increase in overall, NNRTI and PI resistance in North America.ConclusionsOverall, NNRTI and dual NRTI/NNRTI‐associated TDR prevalence was significantly higher in sub‐Saharan Africa studies published between 2014 and 2019 compared with those published between 2009 and 2013. The decreasing proportion of studies from the hardest hit LMIC regions and the shift away from sentinel sites for recent infection suggests that global TDR surveillance efforts and publication of findings require renewed emphasis.
Cytokine release syndrome in COVID-19: Innate immune, vascular, and platelet pathogenic factors differ in severity of disease and sex
Authors: Petrey Aaron C , Qeadan Fares , Middleton Elizabeth A , Pinchuk Irina V , Campbell Robert A , Beswick Ellen J 
Published: September 2020

Abstract
COVID-19 rapidly emerged as a crippling public health crisis in the last few months, which has presented a series health risk. Understanding of the immune response and biomarker analysis is needed to progress toward understanding disease pathology and developing improved treatment options. The goal of this study is to identify pathogenic factors that are linked to disease severity and patient characteristics. Patients with COVID-19 who were hospitalized from March 17 to June 5, 2020 were analyzed for clinical features of disease and soluble plasma cytokines in association with disease severity and sex. Data from COVID-19 patients with acute illness were examined along with an age- and gender-matched control cohort. We identified a group of 16 soluble factors that were found to be increased in COVID-19 patients compared to controls, whereas 2 factors were decreased. In addition to inflammatory cytokines, we found significant increases in factors known to mediate vasculitis and vascular remodeling (PDGF-AA, PDGF-AB-BB, soluble CD40L (sCD40L), FGF, and IP10). Four factors such as platelet-derived growth factors, fibroblast growth factor-2, and IFN-γ-inducible protein 10 were strongly associated with severe disease and ICU admission. Th2-related factors (IL-4 and IL-13) were increased with IL-4 and sCD40L present at increased levels in males compared with females. Our analysis revealed networking clusters of cytokines and growth factors, including previously unknown roles of vascular and stromal remodeling, activation of the innate immunity, as well activation of type 2 immune responses in the immunopathogenesis of COVID-19. These data highlight biomarker associations with disease severity and sex in COVID-19 patients.
Developmental morphology and evolution of extraembryonic membranes of lizards and snakes (Reptilia, Squamata)
Authors: Stewart James R. 
Published: September 2020

AbstractAmniote embryos are supported and nourished by a suite of tissues, the extraembryonic membranes, that provide vascular connections to the egg contents. Oviparous reptiles share a basic pattern of development inherited from a common ancestor; a vascular chorioallantoic membrane, functioning as a respiratory organ, contacts the eggshell and a vascular yolk sac membrane conveys nutrients to the embryo. Squamates (lizards, snakes) have evolved a novel variation in morphogenesis of the yolk sac that results in a unique structure, the yolk cleft/isolated yolk mass complex. This structure is a source of phylogenetic variation in architecture of the extraembryonic membranes among oviparous squamates. The yolk cleft/isolated yolk mass complex is retained in viviparous species and influences placental architecture. The aim of this paper is to review extraembryonic membrane development and morphology in oviparous and related viviparous squamates to explore patterns of variation. The survey includes all oviparous species for which data are available (11 species; 4 families). Comparisons with viviparous species encompass six independent origins of viviparity. The comparisons reveal that both phylogeny and reproductive mode influence variation in extraembryonic membrane development and that phylogenetic variation influences placental evolution. Models of the evolution of squamate placentation have relied primarily on comparisons between independently derived viviparous species. The inclusion of oviparous species in comparative analyses largely supports these models, yet exposes convergent patterns of evolution that become apparent when phylogenetic variation is recognized.