bluuebunny/crossref_metadata_2025_split huggingface dataset:
An enhanced target-enrichment bait set for Hexacorallia provides phylogenomic resolution of the staghorn corals (Acroporidae) and close relatives
Authors: Cowman Peter F. , Quattrini Andrea M. , Bridge Thomas C.L. , Watkins-Colwell Gregory J. , Fadli Nur , Grinblat Mila , Roberts Thomas E. , McFadden Catherine S. , Miller David J. , Baird Andrew H. 
Published: February 2020

AbstractThe phylogenetic utility of targeted enrichment methods has been demonstrated in taxa that often have a history of single gene marker development. These genomic capture methods are now being applied to resolve evolutionary relationships from deep to shallow timescales in clades that were previously deficient in molecular marker development and lacking robust morphological characters that reflect evolutionary relationships. Effectively capturing 1000s of loci, however, in a diverse group across a broad time scale requires a bait set that incorporates multiple baits per locus. We redesigned a custom bait set for the cnidarian class Anthozoa to target 1,436 UCE loci and 1,572 exon regions within the subclass Hexacorallia. We test this redesigned bait set on 99 specimens of hard corals (Scleractinia) spanning both the “complex” (Acroporidae, Agariciidae) and “robust” (Fungiidae) clades. With focused sampling in the staghorn coral genusAcroporawe explore the ability of capture data to inform the taxonomy of a clade deficient in molecular resolution. A mean of 1850 (± 298) loci were captured per taxon (955 UCEs, 894 exons). A 75% complete concatenated alignment included 1792 loci (991 UCE, 801 exons) and ∼1.87 million base pairs. Parsimony informative sites varied from 48% for alignments including all three families, to 1.5% among samples within a singleAcroporaspecies. Maximum likelihood and Bayesian analyses recover highly resolved topologies and robust molecular relationships not previously found with traditional markers within the Acroporidae. Species level relationships within theAcroporagenus do not support traditional morphological groups or morphological phylogenies. Both UCE and exon datasets delineated six well-supported clades withinAcropora.The enhanced bait set for Hexacorallia will allow researchers to survey the evolutionary history of important groups of reef building corals where previous molecular marker development has been unsuccessful.
Bacteriophages targetingAcinetobacter baumanniicapsule induce antimicrobial resensitization
Authors: Altamirano Fernando Gordillo , Forsyth John H. , Patwa Ruzeen , Kostoulias Xenia , Trim Michael , Subedi Dinesh , Archer Stuart , Morris Faye C. , Oliveira Cody , Kielty Luisa , Korneev Denis , O’Bryan Moira K. , Lithgow Trevor J. , Peleg Anton Y. , Barr Jeremy J. 
Published: February 2020

AbstractCarbapenem-resistantAcinetobacter baumanniiis responsible for frequent, hard-to-treat and often fatal healthcare-associated infections. Phage therapy, the use of viruses that infect and kill bacteria, is an approach gaining significant clinical interest to combat antibiotic-resistant infections. However, a major limitation is that bacteria can develop resistance against phages. Here, we isolated phages with activity against a panel ofA. baumanniistrains and focused on clinical isolates AB900 and A9844 and their phages for detailed characterization. As expected, coincubation of the phages with their hostsin vitroresulted in the emergence of phage-resistant bacterial mutants. Genome sequence analysis revealed that phage-resistant mutants harbored loss-of-function mutations in genes from the K locus, responsible for the biosynthesis of the bacterial capsule. Using molecular biology techniques, phage adsorption assays, and quantitative evaluation of capsule production, we established that the bacterial capsule serves as the primary receptor for these phages. As a collateral phenotype of impaired capsule production, the phage-resistant strains could not form biofilms, became fully sensitized to the human complement system, showed increased susceptibility to beta-lactam antibiotics, and became vulnerable to additional phages. Finally, in a murine model of bacteremia, the phage-resistantA. baumanniidemonstrated a diminished capacity to colonize blood and solid tissues. This study demonstrates that phages can be used not only for their lytic activity but, if combined witha posterioriknowledge of their receptors and the mechanism of bacterial resistance, for their potential synergy with other antimicrobial agents, thus providing even broader clinical options for phage therapy.
The vulnerability of working memory to distraction is rhythmic
Authors: Wöstmann Malte , Lui Troby Ka-Yan , Friese Kai-Hendrik , Kreitewolf Jens , Naujokat Malte , Obleser Jonas 
Published: February 2020

AbstractRecent research posits that the cognitive system samples target stimuli in a rhythmic fashion, characterized by target detection fluctuating at frequencies of ~3–8 Hz. Besides prioritized encoding of targets, a key cognitive function is the protection of working memory from distractor intrusion. Here, we test to which degree the vulnerability of working memory to distraction is rhythmic. In an Irrelevant-Speech Task,N= 23 human participants had to retain the serial order of nine numbers in working memory while being distracted by task-irrelevant speech with variable temporal onsets. The magnitude of the distractor-evoked N1 component in the event-related potential as well as behavioural recall accuracy, both measures of memory distraction, were periodically modulated by distractor onset time in approximately 2–4 cycles per second (Hz). Critically, an underlying 2.5-Hz rhythm explained variation in both measures of distraction such that stronger phasic distractor encoding mediated lower phasic memory recall accuracy. In a behavioural follow-up experiment, we tested whether these results would replicate in a task design without rhythmic presentation of target items. Participants (N= 6 with on average >2,500 trials, each) retained two line-figures in memory while being distracted by acoustic noise of varying onset across trials. In agreement with the main experiment, the temporal onset of the distractor periodically modulated memory performance. These results suggest that during working memory retention, the human cognitive system implements distractor suppression in a temporally dynamic fashion, reflected in ~400-ms long cycles of high versus low distractibility.
Maternal separation stress experienced by parents affects ovarian function in first generation of mice
Authors: Khodamoradi Kajal , Khosravizadeh Zahra , Amini-Khoei Hossein , Hosseini Seyed Reza , Dehpour Ahmad Reza , Hassanzadeh Gholamreza 
Published: February 2020

AbstractThe maternal separation stress during postnatal development can adversely affect one’s adulthood. Some parents’ experiences may not only affect the phenotype of parents but also alter the reaction to environmental impacts in the offspring. The aim of this study is to investigate consequences of maternal separation stress in female first generation of mice whose parents were exposed to maternal separation stress. Maternal separation in pups was performed during post-natal days (PND) 2 to 14. Then, female pups of the first-generation were used in present study. The histological changes in ovaries, ROS production (using DCFH-DA assay), mRNA expression of NLRP3, ASC, caspase-1, TLR4, BAX, BCL2 and TNFα genes (using RT-PCR), levels of IL-18, IL-1β, ATP and GPx (using ELISA) and also protein expression of caspase-3 and NLRP3 (using immunocytochemistry) were assessed. Our findings showed that maternal separation stress experienced by parents significantly affects the numbers of primordial and primary follicles. Furthermore, ROS production increased and concentrations of ATP and GPx reduced in the first generation. Also, expression of cytokines and genes involved in inflammation and apoptosis including NLRP3, caspase-1, TLR4, TNFα, IL-1β, IL-18 and BCL2 were significantly affected in the first generation. Our results also showed that this stress significantly increased percentage of caspase-3 and NLRP3 positive cells in the ovarian tissue of the first generation. Our findings suggest that maternal separation stress experienced by parents may influence activation of inflammatory response in the ovarian tissue of their first generation which may induce apoptosis and consequently disturb folliculogenesis process.
From the Roundabout of Molecular Events to Nanomaterial-Induced Chronic Inflammation Prediction
Authors: Majaron Hana , Kokot Boštjan , Sebastijanović Aleksandar , Voss Carola , Podlipec Rok , Zawilska Patrycja , Berthing Trine , López Carolina Ballester , Danielsen Pernille Høgh , Contini Claudia , Ivanov Mikhail , Krišelj Ana , Čotar Petra , Zhou Qiaoxia , Ponti Jessica , Zhernovkov Vadim , Schneemilch Matthew , Doumandji Zahra , Pušnik Mojca , Umek Polona , Pajk Stane , Joubert Olivier , Schmid Otmar , Urbančič Iztok , Irmler Martin , Beckers Johannes , Lobaskin Vladimir , Halappanavar Sabina , Quirke Nick , Lyubartsev Alexander P. , Vogel Ulla , Koklič Tilen , Stoeger Tobias , Štrancar Janez 
Published: February 2020

AbstractNanomaterial-induced diseases cannot be reliably predicted because of the lack of clearly identified causal relationships, in particular between acute exposures and chronic symptoms. By applying advanced microscopies and omics toin vitroandin vivosystems, together within silicomolecular modelling, we have here determined that the long-lasting response to a single exposure originates in the counteracting of a newly discovered nanomaterial quarantining and nanomaterial cycling among different lung cell types. This allows us to predict the nanomaterial-induced spectrum of lung inflammation using onlyin vitromeasurements andin silicomodelling. Besides its profound implications for cost-efficient animal-free predictive toxicology, our work also paves the way to a better mechanistic understanding of nanomaterial- induced cancer, fibrosis, and other chronic diseases.
Nonlinear aeroelastic modeling of aircraft using support vector machine method
Authors: Bagherzadeh Seyed Amin 
Published: February 2020

Purpose
This paper aims to propose a nonlinear model for aeroelastic aircraft that can predict the flight parameters throughout the investigated flight envelopes.

Design/methodology/approach
A system identification method based on the support vector machine (SVM) is developed and applied to the nonlinear dynamics of an aeroelastic aircraft. In the proposed non-parametric gray-box method, force and moment coefficients are estimated based on the state variables, flight conditions and control commands. Then, flight parameters are estimated using aircraft equations of motion. Nonlinear system identification is performed using the SVM network by minimizing errors between the calculated and estimated force and moment coefficients. To that end, a least squares algorithm is used as the training rule to optimize the generalization bound given for the regression.

Findings
The results confirm that the SVM is successful at the aircraft system identification. The precision of the SVM model is preserved when the models are excited by input commands different from the training ones. Also, the generalization of the SVM model is acceptable at non-trained flight conditions within the trained flight conditions. Considering the precision and generalization of the model, the results indicate that the SVM is more successful than the well-known methods such as artificial neural networks.

Practical implications
In this paper, both the simulated and real flight data of the F/A-18 aircraft are used to provide aeroelastic models for its lateral-directional dynamics.

Originality/value
This paper proposes a non-parametric system identification method for aeroelastic aircraft based on the SVM method for the first time. Up to the author’s best knowledge, the SVM is not used for the aircraft system identification or the aircraft parameter estimation until now.
The determinants of integrated reporting quality in financial institutions
Authors: Vitolla Filippo , Raimo Nicola , Rubino Michele , Garzoni Antonello 
Published: February 2020

PurposeThis study aims to investigate the financial and country-level determinants of integrated reporting quality in the financial industry. Specifically, this study analyses the impact of profitability, size, leverage and civil law system on the integrated reporting quality.Design/methodology/approachHypotheses were tested using a regression model on a sample of 87 financial institutions. An integrated reporting (IR)-quality scoreboard was used to measure report quality.FindingsThe results show that IR quality is significantly and positively influenced by profitability, size, financial leverage and the civil law system.Practical implicationsThe results have particularly important implications for large, profitable financial institutions that make greater use of financial leverage and that are localized in non-civil law countries. Managers should increase transparency by expanding the content and quality of the information contained in the integrated reports.Originality/valueThis study contributes to the literature by revealing several financial factors that influence IR quality. To the best of the authors’ knowledge, this is the first study to investigate IR quality in the context of the financial industry.
Towards professionalising Canadian retail management careers
Authors: Gunn Frances , Cappuccitti Anna , Lee Seung Hwan (Mark) 
Published: February 2020

PurposeThe purpose of this study is to investigate patterns in the social construction of occupational jurisdiction and related professional career identity. It examines the agency associated with framing messages that influence perceptions about the professional nature and value of retail management careers. The aim is to identify sources which produce influential messages about perceptions about retail management careers and the content of these messages.Design/methodology/approachThis study utilises a qualitative research methodology (focus-group interviews) to explore the observations of people involved with the monitoring and management of career messages. Two focus groups were conducted with a) nine Canadian retail practitioners and b) seven post-secondary educators from retail management education programmes.FindingsThe focus groups identify five sources of influential messages including (1) part-time retail work experience, (2) educational institutions, (3) parents, (4) retail industry/practitioners and (5) media. They also identify three content themes presented by these sources including (1) the importance of educational requirements, (2) the nature of occupational roles and (3) the value of the career.Research limitations/implicationsThe significance and generalisability of the results are limited by the size and nature of the sample.Practical implicationsThis study makes a practical contribution by identifying potential career awareness strategies.Originality/valueThis research makes a theoretical contribution by expanding understanding of the role of communication with career perceptions and with the related constitution of career professionalisation.
Sustainability of digital humanities projects as a publication and documentation challenge
Authors: Edmond Jennifer , Morselli Francesca 
Published: February 2020

PurposeThis paper proposes a new perspective on the enormous and unresolved challenge to existing practices of publication and documentation posed by the outputs of digital research projects in the humanities, where much good work is being lost due to resource or technical challenges.Design/methodology/approachThe paper documents and analyses both the existing literature on promoting sustainability for the outputs of digital humanities projects and the innovative approach of a single large-scale project.FindingsThe findings of the research presented show that sustainability planning for large-scale research projects needs to consider data and technology but also community, communications and process knowledge simultaneously. In addition, it should focus not only on a project as a collection of tangible and intangible assets, but also on the potential user base for these assets and what these users consider valuable about them.Research limitations/implicationsThe conclusions of the paper have been formulated in the context of one specific project. As such, it may amplify the specificities of this project in its results.Practical implicationsAn approach to project sustainability following the recommendations outlined in this paper would include a number of uncommon features, such as a longer development horizon, wider perspective on project results, and an audit of tacit and explicit knowledge.Social ImplicationsThese results can ultimately preserve public investment in projects.Originality/valueThis paper supplements more reductive models for project sustainability with a more holistic approach that others may learn from in mapping and sustaining user value for their projects for the medium to long terms.
The macroeconomic effects of monetary policy shocks under fiscal constrained
Authors: Jesus Diego Pitta de , Besarria Cássio da Nóbrega , Maia Sinézio Fernandes 
Published: February 2020

PurposeThis paper aims to analyze the macroeconomic effects of a monetary policy shock considering that fiscal policy is under fiscal constraints. For that, a dynamic stochastic general equilibrium (DSGE) model was developed for Brazil, which was estimated through Bayesian econometrics.Design/methodology/approachIn the basic model, the government does not have any type of fiscal restriction. The other two estimated models, however, consider that the fiscal authority implements some kind of fiscal rule. One of these rules is the Constitutional Amendment 95/2016 (EA 95/2016), which includes a limitation for government spending. The other Alternative Rule seeks to represent the characteristics of a more austere fiscal rule, as proposed by Wesselbaum (2017).FindingsIt was possible to verify in this paper that the implementation of EA 95/2016 by the Brazilian government does not produce statistically different results and that it reduces the welfare of the households in relation to the scenario without fiscal rule. Thus, the proportionate benefit of EA 95/2016 is less than the cost associated with this fiscal rule (less welfare). If the government adopts a fiscal constraint similar to the Alternative Rule, it is possible to considerably reduce the interaction between fiscal and monetary policy, thereby reducing the fiscal dominance policy over monetary policy. However, the cost in terms of welfare is much higher than the baseline scenario. Thus, the fiscal authority is subject to a trade-off among public debt stabilization and household welfare.Originality/valueThe study intends to contribute to the literature on three specific points. First, the monetary–fiscal policy interaction within a representative model of the Brazilian economy is discussed. In addition, the study considers that the government can adopt EA 95/2016 and the Alternative Rule, used in the US economy. Second, the impacts of EA 95/2016 and the Alternative Rule on household welfare will be quantified. Finally, two types of individuals (Ricardian and non-Ricardian agents) and two sectors of production (wholesalers and retailers) are considered. In this paper, the DSGE model is estimated, since the previously mentioned authors performed simulations
How effective is government spending on environmental protection in a developing country?
Authors: Moshiri Saeed , Daneshmand Arian 
Published: February 2020

PurposeThe objective of this paper is twofold as follows: first, it explores the relationship between economic growth and the environment in the context of the environmental Kuznets curve (EKC) in Iran, as a semi-industrialized and largest developing economy in the Middle East. Second, it investigates the effectiveness of government spending on environmental protection.Design/methodology/approachThe paper uses the ecological footprint data and an ARDL model to gauge the income and government spending effects on environmental improvement. This method avoids the problems associated with using the regression including a squared income.FindingsThe results find no evidence for a turning point in the income–pollution relationship and no significant impact of government spending on reducing footprint. We conjecture that the structure of the economy and the weak institutional quality may explain the results.Research limitations/implicationsThis includes limited time series data on institutional quality indices and their small variations over time.Practical implicationsCreating an environmental fund using the oil windfall and applying environmental tax/subsidies policies will help address increasing environmental challenges in energy-rich developing countries. Education and public awareness about environmental problems and their impacts on the standard of living are also nonexpensive but effective ways to increase citizen's engagement towards improving environment.Social implicationsThe EKC may take different forms in various countries depending on their economic structure and institution qualities.Originality/valueThe paper uses the ARDL method rather than a commonly used regression with a squared income to estimate the EKC. It also uses ecological footprint as a measure of environmental damage. Exploring government effectiveness in managing public good is also novel in the empirical literature.
The relationship between spiritual leadership to quality of work life and ethical behavior and its implication to increasing the organizational citizenship behavior
Authors: Pio Riane Johnly , Lengkong Florence Daisy Jetty 
Published: February 2020

PurposeThe purpose of this study is to analyze the relationship between spiritual leadership, quality of work life (QWL), ethical behavior, and its implication to organizational citizenship behavior (OCB).Design/methodology/approachThe study design is the quantitative method as an explanatory research with the purpose to explain the phenomena or pattern of correlation between the concepts (Solimun et al., 2017). Focus on this study is the employees in three private hospitals managed by foundations or religious-based institutions as research areas, namely (1) Adventist Hospital; (2) Pancaran Kasih Hospital; (3) Siti Maryam Hospital, Manado, Indonesia. The population in this study was all the employees, and the sample size is 150 respondents (using Slovin’s Formula), by simple random sampling. The analytical method used to test the hypothesis of the research was structural equation modeling (SEM) covariance based called partial least square (PLS).FindingsThe spiritual leadership has the direct effect QWL. The spiritual leadership has the direct effect on ethical behavior. The spiritual leadership does not have the direct effect on OCB. QWL has the direct effect on OCB. The ethical behavior has the direct effect on OCB. The spiritual leadership has the indirect effect on OCB, with QWL and ethical behavior as mediation variables.Originality/valueThis is one of few research studies comprehensively investigating the relationship between spiritual leadership (as exogenous variable), with QWL and ethical behavior (as intervening variable) and OCB (as endogenous variable). Based on the views and opinions of some of the mentioned writers, we assume that spiritual leadership has a relationship with OCB mediated by QWL or ethical behavior.