bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orosomucoid 1 is involved in the development of chronic allograft rejection after kidney transplantation
Authors: Higuchi Haruka , Kamimura Daisuke , Jiang Jing-Jing , Atsumi Toru , Iwami Daiki , Hotta Kiyohiko , Harada Hiroshi , Takada Yusuke , Kanno-Okada Hiromi , Hatanaka Kanako C , Tanaka Yuki , Shinohara Nobuo , Murakami Masaaki 
Published: January 2020

Abstract
Chronic allograft rejection is the most common cause of long-term allograft failure. One reason is that current diagnostics and therapeutics for chronic allograft rejection are very limited. We here show that enhanced NFκB signaling in kidney grafts contributes to chronic active antibody-mediated rejection (CAAMR), which is a major pathology of chronic kidney allograft rejections. Moreover, we found that urinary orosomucoid 1 (ORM1) is a candidate marker molecule and therapeutic target for CAAMR. Indeed, urinary ORM1 concentration was significantly higher in kidney transplant recipients pathologically diagnosed with CAAMR than in kidney transplant recipients with normal histology, calcineurin inhibitor toxicity, or interstitial fibrosis and tubular atrophy. Additionally, we found that kidney biopsy samples with CAAMR expressed more ORM1 and had higher NFκB and STAT3 activation in tubular cells than samples from non-CAAMR samples. Consistently, ORM1 production was induced after cytokine-mediated NFκB and STAT3 activation in primary kidney tubular cells. The loss- and gain-of-function of ORM1 suppressed and promoted NFκB activation, respectively. Finally, ORM1-enhanced NFκB-mediated inflammation development in vivo. These results suggest that an enhanced NFκB-dependent pathway following NFκB and STAT3 activation in the grafts is involved in the development of chronic allograft rejection after kidney transplantation and that ORM1 is a non-invasive candidate biomarker and possible therapeutic target for chronic kidney allograft rejection.
Definitive radiation therapy in patients with unresectable desmoid tumors: a systematic review
Authors: Matsunobu Tomoya , Kunisada Toshiyuki , Ozaki Toshifumi , Iwamoto Yukihide , Yoshida Masahiro , Nishida Yoshihiro 
Published: January 2020

Abstract

Background
Desmoid tumors are rare soft tissue tumors. Wide local excision has been the standard surgical treatment for desmoid tumors. However, this procedure results in high local recurrence rates, so non-surgical treatments should be considered. The aim of this systematic review was to evaluate the effect of radiation therapy on patients with desmoid tumors, especially those with unresectable disease.

Methods
We evaluated studies published between 1 January 1990 and 31 August 2017 and cited in PubMed and Ichushi (in Japanese). All studies evaluating the effect of radiation therapy on desmoid tumors were included. Data regarding radiation dose, recurrence and adverse events were recorded.

Results
Among 218 identified studies, only 6 were finally included in this review. Local control was achieved in 253 of 317 patients with unresectable or unresected tumors who underwent definitive radiation therapy (the crude rate of local control was 79.8%). Toxicity was evaluated in patients who underwent definitive radiation therapy or surgery plus radiation therapy. One of the most common acute complications was skin toxicity. Frequent late complications of radiation therapy included fibrosis/contracture/joint stiffness, skin disorders, lymphedema and pain. Six patients developed secondary malignancies in the radiation field.

Conclusions
In patients treated unsuccessfully with surgery, watchful waiting and pharmacotherapy, radiation therapy may be an option as salvage therapy because of the high rate of local control. Because desmoid tumors frequently develop in young individuals, children and young patients who receive radiation therapy for the treatment of desmoid tumors should be followed up on a long-term basis with periodic monitoring for late radiation toxicities.
Anopheline Mosquito Species Composition, Kdr Mutation Frequency, and Parasite Infectivity Status in Northern Tanzania
Authors: Kweka Eliningaya J , Mazigo Humphrey D , Lyaruu Lucile J , Mausa Emmanuel A , Venter Nelius , Mahande Aneth M , Coetzee Maureen 
Published: January 2020

AbstractThe scaling-up of malaria control interventions in northern Tanzania has resulted in a decline in malaria prevalence and vector species composition. Despite this achievement, residual malaria transmission remains a concern in the area. The main aim of this study was to investigate malaria vector species composition, parasite infectivity rates, and the presence of insecticide knockdown resistance (kdr) mutations in three sites that have experienced a significant decline in malaria in northern Tanzania. Adult mosquitoes were sampled using light traps in houses and hand-aspirators in cowsheds, whereas the standard dipping method was used for sampling mosquito larvae. Adult mosquitoes identified as Anopheles gambiae s.l. and An. funestus s.l. and larval stages III and IV of An. gambiae s.l. were stored in absolute ethanol for further laboratory molecular identification. The identified species in the An. gambiae complex were An. gambiae s.s., An. merus, An. quadriannulatus, and An. arabiensis, whereas the An. funestus group comprised An. funestus s.s., An. rivulorum, and An. leesoni. For An. gambiae s.s. analyzed from Zeneth, 47.6% were kdr-East homozygous susceptible, 35.7% kdr-East heterozygous resistant, 9.6% kdr-East homozygous resistant, and 7.1% undefined, whereas specimens from Kwakibuyu were 45.5% kdr-East homozygous susceptible, 32.7% kdr-East heterozygous resistant, 16.3% kdr-East homozygous resistant, and 5.5% undefined. There were no kdr-West alleles identified from any specimen. The overall malaria parasite infectivity rate was 0.75%. No infections were found in Moshi. The findings indicate that populations of the major malaria vector mosquitoes are still present in the study area, with An. funestus taking a lead in malaria transmission.
Ultrastructural Lesions of Nodo-Paranodopathies in Peripheral Neuropathies
Authors: Vallat Jean-Michel , Magy Laurent , Corcia Philippe , Boulesteix Jean-Marc , Uncini Antonino , Mathis Stéphane 
Published: January 2020

Abstract
Whatever the cause of myelin damage of the peripheral nervous system, the initial attack on myelin by a dysimmune process may begin either at the internodal area or in the paranodal and nodal regions. The term “nodo-paranodopathy” was first applied to some “axonal Guillain-Barré syndrome” subtypes, then extended to cases classified as chronic inflammatory demyelinating polyradiculoneuropathy bearing IgG4 antibodies against paranodal axoglial proteins. In these cases, paranodal dissection develops in the absence of macrophage-induced demyelination. In contrast, the mechanisms of demyelination of other dysimmune neuropathies induced by macrophages are unexplained, as no antibodies have been identified in such cases. Electron microscopy of longitudinal sections of nerve biopsies is useful to visualize and authenticate the characteristic lesions of paranodes/nodes. However, it should be borne in mind that identical ultrastructural aspects are seen in other types of polyneuropathies: Genetic, experimental, and in a few polyneuropathies for which there is no obvious etiology. Ultrastructural nerve studies confirm the initial involvement of nodes/paranodes in various types of acquired and genetic neuropathies. For some of them, the antibodies or the proteins involved by mutations are clearly identified such as Caspr-1, Contactin-1, NFasc155, and NFasc186; other unidentified proteins are likely to be involved as well.
Nontraditional Uses of Live Attenuated Influenza Vaccine: School-Located Influenza Vaccination
Authors: Weinberg Geoffrey A 
Published: January 2020

Abstract
Immunization against influenza continues to be the best method of preventing influenza infection in children, and additionally, indirectly helping to lower disease in adults, given the role of children as “spreaders” of influenza to the community at large. An increasing evidence base exists for the use of school-located influenza vaccination (SLIV) programs to increase the influenza vaccination rates among children. Live, attenuated influenza vaccine (LAIV) has unique characteristics that make it useful for SLIV programs, including ease of immunization without needles, faster delivery, and in many (but not all) years, good vaccine effectiveness. Reviewed herein are results of selected published trials as well as guidance on planning a successful SLIV program.
Semi-automated prediction approach of target shifts using machine learning with anatomical features between planning and pretreatment CT images in prostate radiotherapy
Authors: Kai Yudai , Arimura Hidetaka , Ninomiya Kenta , Saito Tetsuo , Shimohigashi Yoshinobu , Kuraoka Akiko , Maruyama Masato , Toya Ryo , Oya Natsuo 
Published: January 2020

Abstract
The goal of this study was to develop a semi-automated prediction approach of target shifts using machine learning architecture (MLA) with anatomical features for prostate radiotherapy. Our hypothesis was that anatomical features between planning computed tomography (pCT) and pretreatment cone-beam computed tomography (CBCT) images could be used to predict the target, i.e. clinical target volume (CTV) shifts, with small errors. The pCT and daily CBCT images of 20 patients with prostate cancer were selected. The first 10 patients were employed for the development, and the second 10 patients for a validation test. The CTV position errors between the pCT and CBCT images were determined as reference CTV shifts (teacher data) after an automated bone-based registration. The anatomical features associated with rectum, bladder and prostate were calculated from the pCT and CBCT images. The features were fed as the input with the teacher data into five MLAs, i.e. three types of artificial neural networks, support vector regression (SVR) and random forests. Since the CTV shifts along the left–right direction were negligible, the MLAs were developed along the superior–inferior and anterior–posterior directions. The proposed framework was evaluated from the residual errors between the reference and predicted CTV shifts. In the validation test, the mean residual error with its standard deviation was 1.01 ± 1.09 mm in SVR using only one feature (one click), which was associated with positional difference of the upper rectal wall. The results suggested that MLAs with anatomical features could be useful in prediction of CTV shifts for prostate radiotherapy.
Robustness of Gaian feedbacks to climate perturbations
Authors: Alcabes Olivia D N , Olson Stephanie , Abbot Dorian S 
Published: January 2020

ABSTRACT
The Gaia hypothesis postulates that life regulates its environment to be favorable for its own survival. Most planets experience numerous perturbations throughout their lifetimes such as asteroid impacts, volcanism, and the evolution of their host star’s luminosity. For the Gaia hypothesis to be viable, life must be able to keep the conditions of its host planet habitable, even in the face of these challenges. ExoGaia, a model created to investigate the Gaia hypothesis, has been previously used to demonstrate that a randomly mutating biosphere is in some cases capable of maintaining planetary habitability. However, those model scenarios assumed that all non-biological planetary parameters were static, neglecting the inevitable perturbations that real planets would experience. To see how life responds to climate perturbations to its host planet, we created three climate perturbations in ExoGaia: one rapid cooling of a planet and two heating events, one rapid and one gradual. The planets on which Gaian feedbacks emerge without climate perturbations are the same planets on which life is most likely to survive each of our perturbation scenarios. Biospheres experiencing gradual changes to the environment are able to survive changes of larger magnitude than those experiencing rapid perturbations, and the magnitude of change matters more than the sign. These findings suggest that if the Gaia hypothesis is correct, then typical perturbations that a planet would experience may be unlikely to disrupt Gaian systems.
Cooling theory faced with old warm neutron stars: role of non-equilibrium processes with proton and neutron gaps
Authors: Yanagi Keisuke , Nagata Natsumi , Hamaguchi Koichi 
Published: January 2020

ABSTRACT
Recent observations have found several candidates for old warm neutron stars whose surface temperatures are above the prediction of the standard neutron star cooling scenario, and, thus, require some heating mechanism. Motivated by these observations, we study the non-equilibrium beta process in the minimal cooling scenario of neutron stars, which inevitably occurs in pulsars. This out-of-equilibrium process yields the late-time heating in the core of a neutron star, called the rotochemical heating, and significantly changes the time evolution of the neutron star surface temperature. To perform a realistic analysis of this heating effect, we include the proton-singlet- and neutron-triplet-pairing gaps simultaneously in the calculation of the rate and emissivity of this process, where the dependence of these pairing gaps on the nucleon density is also taken into account. We then compare the predicted surface temperature of neutron stars with the latest observational data. We show that the simultaneous inclusion of both proton and neutron gaps is advantageous for the explanation of the old warm neutron stars since it enhances the heating effect. It is then found that the observed surface temperatures of the old warm millisecond pulsars, J2124−3358 and J0437−4715, are explained for various choices of nucleon gap models. The same set-up is compatible with the observed temperatures of ordinary pulsars, including old warm ones, J0108−1431 and B0950+08, by choosing the initial rotational period of each neutron star accordingly. In particular, the upper limit on the surface temperature of J2144−3933 can be satisfied if its initial period is $\gtrsim 10\, \mathrm{ms}$.
Youth Vaping and Tobacco Use in Context in the United States: Results From the 2018 National Youth Tobacco Survey
Authors: Glasser Allison M , Johnson Amanda L , Niaura Raymond S , Abrams David B , Pearson Jennifer L 
Published: January 2020

AbstractIntroductionAccording to the National Youth Tobacco Survey (NYTS), youth e-cigarette use (vaping) rose between 2017 and 2018. Frequency of vaping and concurrent past 30-day (p30d) use of e-cigarettes and tobacco products have not been reported.MethodsWe analyzed the 2018 NYTS (N = 20 189) for vaping among all students (middle and high school; 6–12th grades; 9–19 years old) by frequency of vaping, exclusive vaping, p30d poly-product use (vaping and use of one or more tobacco product), and any past tobacco product use.ResultsIn 2018, 81.4% of students had not used any tobacco or vapor product in the p30d, and 86.2% had not vaped in the p30d. Among all students, of the 13.8% vaped in the p30d, just over half vaped on ≤5 days (7.0%), and roughly a quarter each vaped on 6–19 days (3.2%) and on 20+ days (3.6%). Almost three quarters of p30d vapers (9.9%) reported past or concurrent tobacco use and the remainder (3.9%) were tobacco naïve. 2.8% of students were tobacco naïve and vaped on ≤5 days; 0.7% were tobacco-naïve and vaped on 6–19 days, and 0.4% were tobacco-naïve and vaped on 20+ days.ConclusionsVaping increased among US youth in 2018 over 2017. The increases are characterized by patterns of low p30d vaping frequency and high poly-product use, and a low prevalence of vaping among more frequent but tobacco naïve vapers.ImplicationsResults underscore the importance of including the full context of use patterns. The majority of vapers (60.0%–88.9% by use frequency) were concurrent p30d or ever tobacco users. About 4% of students were tobacco naïve and vaped in the p30d, but few (0.4%) vaped regularly on 20 or more days. Reporting youth vaping data with frequency and tobacco product co-use will give public health decision-makers the best possible information to protect public health.
Mortality among seafarers: a register-based follow-up study
Authors: Rinne H , Laaksonen M , Notkola V , Shemeikka R 
Published: January 2020

Abstract

Background
Seafarers are exposed to many occupational risk factors.

Aims
To study whether there are differences in mortality between seafarers and other employees, whether there are variations in seafarers’ mortality between different seafaring occupations and whether these differences can be explained by sociodemographic factors.

Methods
A register-based study of all seafarers aged 25–64 years, resident in Finland in 2000 with minimum 5 years of cumulative seafaring experience on Finnish vessels and other employees, followed for mortality 2001–13. Analysis methods included age standardized death rates, mortality ratios (SMR) and Cox proportional hazard model.

Results
During the follow-up period 2001–13, there were 81,035 person years and 382 deaths in the cohort of seafarers. Seafarers had 1.3 times higher risk of death (men SMR 132, 95% confidence intervals [CI] 118–147, women SMR 125, 95% CI 99–157) than other employees. Mortality was especially high in alcohol-related causes (men SMR 172, 95% CI 126–233, women SMR 262, 95% CI 131–525) and causes related to smoking. Controlling for sociodemographic characters strengthened the risk compared to other occupations. Mortality was high among male deck and engine crew and among male and female galley personnel. The mortality differences between different seafaring occupations were partly explained by adjustments of sociodemographic characters.

Conclusions
Seafarers still have increased mortality among men after adjustment of sociodemographic characters. Results by causes of death suggest that changing practices to enable healthy behaviour are important.
A circuit perspective on narcolepsy
Authors: Adamantidis A R , Schmidt M H , Carter M E , Burdakov D , Peyron C , Scammell Thomas E 
Published: January 2020

Abstract
The sleep disorder narcolepsy is associated with symptoms related to either boundary state control that include excessive daytime sleepiness and sleep fragmentation, or rapid eye movement (REM) sleep features including cataplexy, sleep paralysis, hallucinations, and sleep-onset REM sleep events (SOREMs). Although the loss of Hypocretin/Orexin (Hcrt/Ox) peptides or their receptors have been associated with the disease, here we propose a circuit perspective of the pathophysiological mechanisms of these narcolepsy symptoms that encompasses brain regions, neuronal circuits, cell types, and transmitters beyond the Hcrt/Ox system. We further discuss future experimental strategies to investigate brain-wide mechanisms of narcolepsy that will be essential for a better understanding and treatment of the disease.
Reported Prevalence of Maternal Hepatitis C Virus Infection in the United States
Authors: Rossi Robert M. , Wolfe Christopher , Brokamp Richard , McAllister Jennifer M. , Wexelblatt Scott , Warshak Carri R. , Hall Eric S. 
Published: January 2020

OBJECTIVE:
To quantify the reported prevalence and trend of maternal hepatitis C virus (HCV) infection in the United States (2009–2017) and identify maternal characteristics and obstetric outcomes associated with HCV infection during pregnancy.

METHODS:
We conducted a population-based retrospective cohort study of all live births in the United States for the period 2009 through 2017 using National Center for Health Statistics birth records. We estimated reported prevalence and trends over this time period for the United States. We also evaluated demographic factors and pregnancy outcomes associated with maternal HCV infection for a contemporary U.S. cohort (2014–2017).

RESULTS:
During the 9-year study period, there were 94,824 reported cases of maternal HCV infection among 31,207,898 (0.30%) live births in the United States. The rate of maternal HCV infection increased from 1.8 cases per 1,000 live births to 4.7 cases per 1,000 live births (relative risk [RR] 2.7, 95% CI 2.6–2.8) in the United States. After adjusting for various confounders in the contemporary U.S. cohort (2014–2017), demographic characteristics associated with HCV infection included non-Hispanic white race (adjusted RR 2.8, 95% CI 2.7–2.8), Medicaid insurance (adjusted RR 3.3, CI 3.2–3.3), and cigarette smoking (adjusted RR 11.1, CI 10.9–11.3). Co-infection during pregnancy with hepatitis B (adjusted RR 19.2, CI 18.1–20.3), gonorrhea, chlamydia, or syphilis were also associated with maternal HCV infection. Obstetric and neonatal outcomes associated with maternal HCV infection included cesarean delivery, preterm birth, maternal intensive care unit admission, blood transfusion, having small-for-gestational-age neonates (less than the 10th percentile) birth weight, neonatal intensive care unit admission, need for assisted neonatal ventilation, and neonatal death.

CONCLUSION:
The reported prevalence of maternal HCV infection has increased 161% from 2009 to 2017.
Severe Maternal Morbidity and Mortality Among Indigenous Women in the United States
Authors: Kozhimannil Katy B. , Interrante Julia D. , Tofte Alena N. , Admon Lindsay K. 
Published: January 2020

OBJECTIVE:
To describe delivery-related severe maternal morbidity and mortality among indigenous women compared with non-Hispanic white (white) women, distinguishing rural and urban residents.

METHODS:
We used 2012–2015 maternal hospital discharge data from the National Inpatient Sample to conduct a pooled, cross-sectional analysis of indigenous and white patients who gave birth. We used weighted multivariable logistic regression and predictive population margins to measure health conditions and severe maternal morbidity and mortality (identified using International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis and procedure codes) among indigenous and white patients, to test for differences across both groups, and to test for differences between rural and urban residents within each racial category.

RESULTS:
We identified an estimated 7,561,729 (unweighted n=1,417,500) childbirth hospitalizations that were included in the analyses. Of those, an estimated 101,493 (unweighted n=19,080) were among indigenous women, and an estimated 7,460,236 (unweighted n=1,398,420) were among white women. The incidence of severe maternal morbidity and mortality was greater among indigenous women compared with white women (2.0% vs 1.1%, respectively; relative risk [RR] 1.8, 95% CI 1.6–2.0). Within each group, incidence was higher among rural compared with urban residents (2.3% for rural indigenous women vs 1.8% for urban indigenous women [RR 1.3, 95% CI 1.0–1.6]; 1.3% for rural white women vs 1.2% for urban white women [RR 1.1, 95% CI 1.1–1.2]).

CONCLUSION:
Severe maternal morbidity and mortality is elevated among indigenous women compared with white women. Incidence is highest among rural indigenous residents. Efforts to improve maternal health should focus on populations at greatest risk, including rural indigenous populations.