bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polysaccharide Vaccines. Current Approaches to Quality Assessment Issues
Authors: Ustinnikova O. B. , Alekseeva I. A. , Abramtseva M. V. , Nemirovskaya T. I. , Movsesyants A. A. 
Published: November 2020

Relevance. Polysaccharide vaccine quality assessment must, on the one hand, comply with modern domestic and international regulatory documents, and on the other hand, reflect the characteristics of newly developed drugs. The list of drugs registered on the Russian market is constantly expanding due to the development of new effective vaccines and the introduction of new production sites. Thus, the expert requirements for assessing the quality of these drugs and the information content of the documents submitted as part of the registration dossier need to be updated.Aims. The aim is to update the expert assessment of quality in preclinical and clinical studies of polysaccharide vaccines, as well as to revise the evaluation of quality parameters depending on the composition and structure of the finished product.Conclusions. We highlight the key problematic aspects of assessing the protective properties of purified polysaccharides: in particular, the problems related to the natural immunity of animals to diseases caused by bacterial species that are relevant to humans and, as a result, the lack of an adequate experimental model. Modern trends in the characterization and subsequent confirmation of the structure authenticity of purified and conjugated polysaccharides are taken into account. An analysis of the latest international and domestic pharmacopoeial requirements for the quality of polysaccharide vaccines is carried out. The disadvantages of selected methodological approaches to the evaluation of quality parameters such as «Identification» and «Molecular mass distribution» are noted. It is shown that it is necessary to generate recommendations for the examination of polysaccharide vaccines which would unify the recommendations for completing registration dossiers and forming specification files by taking into account each individual peculiarity of this type of drugs.
Current Trends in Epidemiology of Rabies in Belarus
Authors: Hanenko O. N. , Kolomiets N. D. , Tonko O. V. 
Published: November 2020

Relevance. According to expert estimates, tens of thousands of people die every year from rabies infection, mainly in Asia and Africa, for whom the main source of transmission of the virus is dogs.The purpose of the work is to establish the epidemiological characteristics of rabies infection in Belarus from 2013 to 2018 in the absence of cases of rabies among the population. Materials and methods. A retrospective epidemiological analysis of treatment demand for anti-rabies medical care (ARMС), analysis of data on an epizootic situation was applied.Results and discussion. The population treatment demand for ARMС ranged from 209.60/0000 to 227.20/0000 and was characterized by higher rates 1.6–1.7 times (P ≤ 0.05) among people under the age of 18. The results of monitoring the epizootic situation of rabies revealed that among all wild animals the proportion of «fox» rabies was 80.7%, while 94.4% of the patients were injured by dogs and cats. In 2018 has increased in 3.3 times (P ≤ 0.02) the frequency of treatment persons with the 3rd damage category and in 1.6 increase (P ≤ 0.05) in the proportion of rabies of farm animals in the structure of the reasons for applying for ARMС in comparison with 2013.Conclusion. In Belarus, the relevance of the problem of rabies infection is determined by the activity of the epizootic process, the consistently high treatment demand for ARMС, the events of contacts of the population, including mass, with rabies animals, the annual increase in the frequency of registration of the 3rd category of damage, as well as refusals of immunization and spontaneous interruption of preventive immunization by patients.
Evaluation of the preventive effectiveness of influenza vaccines in St. Petersburg
Authors: Erofeeva M. K. , Stukova M. A. , Shakhlanskaya E. V. , Buzitskaya Zh. V. , Maksakova V. L. , Krainova T. I. , Chirkina T. M. , Pisareva M. M. , Lioznov D. A. 
Published: November 2020

Background. The influenza vaccination coverage has steadily increased in the Russian Federation. The introduction of new domestic influenza vaccines into practice and the study of their effectiveness are of great importance for public health. However, a systematic analysis of the effectiveness of vaccines manufactured and used in Russia in recent years has not been performed. The aim ofthe study was to assess the epidemiological effectiveness of three domestic influenza vaccines in St. Petersburg during the 2018–2019 epidemic season.Material and methods. The organized community of 1892 young students aged 18 to 23 years has been under supervision during the period of time from October 2018 to March 2019. Influenza vaccines Grippol Plus, Sovigripp, and Ultrix were used for vaccination.Results and discussion. Prophylactic vaccination with influenza vaccines Sovigripp, Grippol Plus and Ultrix in the fall of 2018 led to a decrease in the incidence of influenza and other acute respiratory infections (ARI) by a total of 1.6–3.8 times; a decrease in the incidence of influenza by 2.7–7.1 times; the total protective efficacy of vaccines against influenza and ARI was 52.4%, and against influenza, taking into account laboratory correction, 73.3%.Conclusions. Under the conditions of the viruses circulating in Russia and in St. Petersburg in the 2018–2019 epidemic season the strains introduced into the composition of influenza vaccines, domestic influenza vaccines were characterized by good tolerance, were safe, areactogenic and had a pronounced protective effect. If the viruses circulating in Russia and in St. Petersburg in the 2018–2019 epidemic season corresponded to the strains introduced into the composition of influenza vaccines, domestic influenza vaccines, showing good tolerance, safety and low reactogenicity, had a pronounced protective effect.
Cinematographic High-Contrast Lighting Can Facilitate Empathetic Affective Mimicry
Authors: Voodla Alan , Lotman Elen , Kolnes Martin , Naar Richard , Uusberg Andero 
Published: November 2020

AbstractDo cinematographic lighting techniques affect film viewers’ empathic reactions? We investigated the effect of high- and low-contrast lighting on affective empathy toward depicted actors. Forty one participants watched short clips of professional actors expressing happiness, anger, and disgust, and rated the valence and intensity of their own and actors’ emotional states. Affective empathy was assessed through the extent of the facial mimicry of actors’ emotional expressions and quantified through electromyographic activation of expression-specific facial muscles. We managed to elicit facial mimicry for happiness and anger, but not for disgust. High-contrast lighting further amplified empathic mimicry for happy but not for angry expressions. High-contrast lighting also amplified subjective feelings elicited by angry and disgusted but not happy expressions. We conclude that high-contrast lighting can be an effective means for influencing film viewers’ empathic reactions through the low road to empathy, even as the overall impact of lighting also relies on the high road to empathy.
The Post-Covid-19 Reality and Economic Theory
Authors: Trputec Zoran , Šantić Nataša 
Published: November 2020

This paper examines interconnectedness between Covid-19 and six nested subsystems of our planet: people, economy, society, anthroposphere, biosphere and planetosphere. It argues the complexity inside of them and in their interactions. The main question is what paradigmatic shift related to sustainable development economics did Covid-19 initiate, and what are the changes in paradigmatic manifestations of a post Covid-19 sustainable economic theory. Through comparison between neoclassical economics together with neoclassical paradigm manifestations, and what should be changed to avoid business as usual and enhance environmental economy, the paper concludes that much of everyday economic intellectual constructs and activities, including dominant economic theory is the part of the present reality that is not sustainable and has to be changed.
Contenido de materia orgánica en suelos de sistemas silvopastoriles establecidos en el Chaco Central paraguayo
Authors: Díaz Lezcano Maura Isabel , Gamarra Lezcano Cynthia Carolina , Ruiz Diaz Susana , Vera de Ortiz Mirtha 
Published: November 2020

El sistema silvopastoril se caracteriza por asociación de ganadería, árboles y pastura, la interacción entre estos componentes aporta beneficios tanto al suelo, como a la pastura, al ganado y a los árboles y permite un aumento en la productividad y la diversificación de la producción. Para conocer la influencia del componente arbóreo del sistema silvopastoril sobre el contenido de materia orgánica del suelo se llevó a cabo un estudio exploratorio en propiedades privadas ubicadas en los Departamento de Boquerón y Presidente Hayes del Chaco Central paraguayo. Se instalaron 8 parcelas permanentes de 1 ha cada una en las que se midieron y registraron todos los individuos de algarrobo (Prosopis spp), se identificaron y extrajeron muestras de pastura de subparcelas de 1m2 que se ubicaron bajo la copa de los árboles y fuera de la copa para comparar la biomasa de la pastura, se extrajeron muestras de suelo bajo las condiciones mencionadas y a dos profundidades, de 0 a 10 cm y de 10 a 30 cm, para comparar el contenido de materia orgánica, carbono y nitrógeno. El componente arbóreo estaba integrado por algarrobo blanco (Prosopis alba) y algarrobo negro (Prosopis nigra) asociados a pastura implantada, Gatton panic (Panicum máximum cv Gatton panic) pasto Pangola (Digitaria decumbens) y pasto Buffel (Cenchrus ciliaris) mayoritariamente. No se registraron diferencias significativas en el contenido de materia orgánica, carbono y nitrógeno entre condiciones de sol y de sombra, pero sí al variar la profundidad. Bajo las condiciones del presente estudio no se registró una influencia significativa del componente arbóreo sobre el contenido de materia orgánica.
КЛЮЧОВІ АСПЕКТИ СТРАТЕГУВАННЯ АПК ПІВНІЧНОГО РЕГІОНУ: ОСОБЛИВОСТІ, ТЕНДЕНЦІЇ ТА ПЕРСПЕКТИВИ
Authors: Мустафаев А. А. 
Published: November 2020

Статья пFormulation of the problem. The article is dedicated to the problem of disclosure of key aspects of agribusiness strategy in the Komi Republic. The aim is to develop appropriate theoretical and practical recommendations for the formation of basic principles and to create necessary conditions for the strategic development of the agro-industrial complex of the region. The subject is the deployment of a scientific approach to solving key tasks and goals for stable development of the agro-industrial complex of the region. Research methods are scientific abstraction, complex-system approach, historical and logical method, analysis and synthesis, observations. The hypothesis consists of creation of a solid financial and production base for the region's agro-industrial complex - the formation of reliable and long-term sources of investment. The state of key indicators of economic activity of the agro-industrial complex is determined, and opportunities for improving the efficiency of production capacities are identified. Presentation of the main material. The agro-industrial complex as an intersectoral, multifunctional and multi-level organizational structure has not only internal, but also external incentives for development. Therefore, the effectiveness of the strategic development of the agro-industrial complex should have the following aspects: manageability, purposefulness, financial feasibility, integrity of organizational structures and technological development, functions of integration behavior, relations with the external environment (natural, financial, economic, environmental), living conditions of the population. The originality and practical significance consist of the recommendation of a comprehensive and systematic approach to solving the tasks set. Conclusions. the tasks of strategizing the agro-industrial complex of the region for the future should be based not only on the efficiency of the used production elements, but also on a competitive mechanism covering the entire production and market system. The prospects for further research are to conduct large-scale intersectoral financial, economic, and other adjustments in various macro, meso and microeconomic levels of the agroindustrial complex of the region
Sosialisasi dan Edukasi SNI 2052:2017 Tentang Baja Tulangan Beton Di SMKN 4 Tangerang
Authors: Mayasari Devita 
Published: November 2020

Material baja tulangan beton beton merupakan material yang penting dalam konstruksi beton bertulang. Kemampuan tulangan beton dalam menerima kuat tarik yang tinggi dan kelemahan beton dalam kuat tarik menjadi dasar pembuatan beton bertulang. Setiap negara memiliki standar masing-masing, tak terkecuali Indonesia yang memiliki Standar Nasional Indonesia (SNI). SNI seringkali dilakukan update dalam mengikuti perkembangan ilmu dan pengetahuan terbaru. Pada saat ini standar yang digunakan untuk baja tulangan beton di Indonesia yang terbaru adalah SNI 2502:2017. Namun standar ini belum tersosialisasikan dengan baik karena keterbatasan biaya dan sumber daya. Dengan adanya kegiatan Program Kemitraan Masyarakat dengan tema “Sosialisasi dan Edukasi SNI 2052:2017 Tentang Baja Tulangan Beton Di SMKN 4 Tangerang” mampu memberikan pengetahuan dan pemahaman kepada para guru dan siswa SMKN 4 Tangerang khususnya Jurusan Teknik Sipil Teknik Konstruksi Batu dan Beton.
Students Perceptions in Online Class Learning During the Covid-19 Pandemic
Authors: Surani Dewi , Hamidah Hamidah 
Published: November 2020

The article was to determine student perceptions in online learning. This research was conducted by survey method by giving questionnaires to 239 active students of Bina Bangsa University. Quantitative data were analyzed by descriptive statistics and qualitative data from open-ended questions to gain insight into student perceptions. The analysis shows that 80% of students are willing to take part in online learning, 62% of students claim online learning provides benefits, and 32% of students have difficulty understanding the material. In conclusion, the perception of students in online learning is relatively good with several obstacles that require improvement. So it is recommended that online learning should be planned, implemented, and evaluated in order to minimize problems and maximize the achievement of learning objectives An abstract should explain a brief, comprehensive summary of article contents; it allows readers to survey.
Keywords: Student Perception, Online Learning, Covid-19 Pandemic
Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease
Authors: Brito Victor Gustavo Balera , Patrocinio Mariana Sousa , Linjardi Maria Carolina , Barreto Ayná Emanuelli Alves , Frasnelli Sabrina CT , Lara Vanessa , Santos Carlos Ferreira , Oliveira Sandra Helena Penha 
Published: November 2020

Periodontal disease (PD) is a prevalent inflammatory disease with the most severe consequence being the loss of the alveolar bone and teeth. We therefore aimed to evaluate the effects of telmisartan (TELM), an angiotensin II type 1 receptor (Agtr1) antagonist, on the PD-induced alveolar bone loss, in Wistar (W) and Spontaneous Hypertensive Rats (SHRs). PD was induced by ligating the lower first molars with silk, and 10 mg/kg TELM was concomitantly administered for 15 days. The hemimandibles were subjected to microtomography, ELISA was used for detecting tumor necrosis factor (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), CXCL3, and CCL2, while qRT-PCR was used for analyzing expression of components of renin-angiotensin system (RAS) (Agt, Ace, Agt1r, Agt2r, Ace2, and Masr), and bone markers (Runx2, Osx, Catnb, Alp, Col1a1, Opn, Ocn, Bsp, Bmp2, Trap, Rank, Rankl, CtsK, Mmp-2, Mmp-9, and osteoclast-associated receptor (Oscar)). The SHR + PD group showed greater alveolar bone loss than the W + PD group, what was significantly inhibited by treatment with TELM, especially in the SHR group. Additionally, TELM reduced the production of TNF-α, IL-1β, and CXCL3 in the SHR group. The expression of Agt increased in the groups with PD, while Agtr2 reduced, and TELM reduced the expression of Agtr1 and increased the expression of Agtr2, in W and SHRs. PD did not induce major changes in the expression of bone formation markers, except for the expression of Alp, which decreased in the PD groups. The bone resorption markers expression, Mmp9, Ctsk, and Vtn, was higher in the SHR + PD group, compared to the respective control and W + PD group. However, TELM attenuated these changes and increased the expression of Runx2 and Alp. Our study suggested that TELM has a protective effect on the progression of PD, especially in hypertensive animals, as evaluated by the resorption of the lower alveolar bone. This can be partly explained by the modulation in the expression of Angiotensin II receptors (AT1R and AT2R), reduced production of inflammatory mediators, the reduced expression of resorption markers, and the increased expression of the bone formation markers.
Clinical usefulness of ventilator associated events in predicting ventilator associated pneumonia
Authors: Havaldar Amarja Ashok , Rajgopalan Natarajan , Gupta Vipin , PH Manjunath 
Published: November 2020

Background-Ventilator associated pneumonia (VAP) is the most common nosocomial infection in intensive care unit (ICU) patients. Traditionally clinical pulmonary infection score (CPIS) has been used in the diagnosis of VAP. There is no firm agreement among critical care and infectious disease specialists regarding the diagnosis of VAP. The aim of this study was to study the association between these new conditions and VAP and whether if any of these precedes the diagnosis of VAP by CPIS.
Materials and Methods: A prospective observational study was conducted from January 2014 to 31st March 2014 (IEC ref 2014/226A). Inclusion criteria of our study were patients requiring invasive mechanical ventilation for > 2 calendar days. Ventilator associated conditon(VAC) and infection related ventilator associated condition (IVAC) were diagnosed based on CDC criteria.
Results -Consecutive hundred patients were screened for the study. Thirteen patients were excluded. Out of eighty-seven patients, fifteen developed VAC, out of whom thirteen developed IVAC and seven patients developed VAP as per CPIS. Diagnosis of VAC preceded diagnosis of VAP in three patients. No temporal relationship was noted in four patients
Conclusions- This study has shown significant association between VAC, IVAC and CPIS criteria for VAP. From our study, there is a suggestion of VAC preceding the diagnosis of VAP by CPIS criteria. However, this needs further validation from the future studies with a larger number of patients.
PENAMBANGAN DATA PENGUNJUNG HOTEL MENGGUNAKAN MODEL SNOWFLAKE UNTUK MENDUKUNG KEBIJAKAN PEMERINTAH BANGKA BELITUNG DIBIDANG PARIWISATA
Authors: Yurindra Yurindra , Romadiana Parlia , Sarwindah Sarwindah 
Published: November 2020

Pengolahan data pengunjung hotel pada saat ini dirasa semakin dibutuhkanuntuk pengolahan informasi wisatawan, terutama bila itu akan digunakan sebagai informasi untuk membuat kebijakan bagi Pemerintah daerah yang ingin memajukan sektor pariwisata di daerahnya. Pemerintah daerah harus mampu menentukan kebijakan strategis dan taktis dalam mengangkat tujuan dari sektor pariwisata yang dimaksud.Yang jadi masalah adalah bahwa tidak semua pemerintah daerah memiliki dan menyadari pentingnya data pengunjung hotel sebagai informasi penunjang bagi kemajuan sektor pariwisata didaerahnya. Untuk itu dirasa perlu membuat dan menetukan indikator berdasarkan data pengujung yang dibutuhkan sebagai alat penambangan data yang dapat digunakan sebagai basisdata bagi pemerintah daerah dalam melakukan analisis terhadap pengunjung hotel. Indikator data pengunjung tersebut antara lain terkait dengan : nama pengunjung, agama, pekerjaan, tujuan menginap, asal pengunjung, kisaranumur, tatacara pembayaran, lama menginap ,tipe jenis kamar apa yang umumnya mereka pesan. Data dari indikator tersebut akan menjadi sebuah informasi penting bagi Pemerintah daerah Bangka belitung untuk menentukan kebijakan dalam melakukan percepatan peningkatan wisatawan di wilayah kepulauan Bangka belitung. Penambangan data dari indikator yang dimaksud menggunakan model Snowflake dalam datamining, sehingga mampu memperkecil ruang penyimpanan dan data yang ada mudah di update . Metode penelitian menggunakan penelitian terapan karena hasil dari penelitian diharapkan akan langsung dapat digunakan untuk keperluan praktis yaitu pengembangan kebijakan dibidang pariwisata, disamping itu penelitian terapan memungkinkan untuk melakukan modifikasi indikator dari hotel dan dinas terkait untuk menemukan beberapa indikator baru maupun kombinasi dari beberapa indikator tersebut.

Kata kunci — snowflake,datawarehouse, pariwisata, perhotelan, datamining
John Buckley and John O’Flynn (eds), <i>Ceol Phádraig: Music at St Patrick’s College Drumcondra 1875–2016</i> (2019)
Authors: McCarthy Marie 
Published: November 2020

A review of John Buckley and John O’Flynn (eds), Ceol Phádraig: Music at St Patrick’s College Drumcondra 1875–2016 (Dublin: Carysfort Press, & Oxford, UK: Peter Lang, 2019). ISBN 978-1-78997-579-6
FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN HIPERTENSI DI WILAYAH KERJA PUSKESMAS BARA-BARAYYA KOTA MAKASSAR
Authors: Nildawati  , Muh. Fajar Pahrir  , Nur Rahma N  
Published: November 2020

The aim of this study was to determine the factors associated of hypertension in the working area of ​​Puskesmas Bara-barayya, Makassar in 2019. The type of this research is a quantitative study with an observational analytic and approach to case control research design. The sample consisted of 50 people, 25 case groups and 25 control groups with the sampling method is simple random sampling and purposive sampling. Data analysis used chi square test with significance level α = 0.05. The results showed that there was a relationship between dietary patterns (p value = 0.002, OR = 6.729) with the incidence of hypertension, and there was no significant relationship between sports habits (p = 0.136), alcohol consumption (p = 0.480), smoking behavior (p = 0.074), stress level (p = 0.312), sleep patterns (p = 0.440), and genetic (p = 0.152) with the incidence of hypertension. Puskesmas staff are expected to intervene in community eating patterns in the Bara-Baraya Puskesmas work area.