bluuebunny/crossref_metadata_2025_split huggingface dataset:
Purinergic signalling in the cardiovascular system—a tribute to Geoffrey Burnstock
Authors: Ralevic Vera 
Published: November 2020

AbstractGeoffrey Burnstock made groundbreaking discoveries on the physiological roles of purinergic receptors and led on P2 purinergic receptor classification. His knowledge, vision and leadership inspired and influenced the international scientific community. I had the privilege of spending over 10 years (from 1985) with Geoff at the Department of Anatomy and Developmental Biology, initially as a PhD student and then as a postdoctoral research fellow. I regarded him with enormous admiration and affection. This review on purinergic signalling in the cardiovascular system is a tribute to Geoff. It includes some personal recollections of Geoff.
Zur Erschließung der Nutzung von Forschungsergebnissen durch Lehrpersonen. Forschungsrelevanz zwischen Theorie und Praxis
Authors: Hinzke Jan-Hendrik , Gesang Johanna , Besa Kris-Stephen 
Published: November 2020

ZusammenfassungIm deutschsprachigen Raum hat sich der Befund verfestigt, dass Lehrpersonen Forschungsergebnisse tendenziell als interessant einschätzen, diese aber kaum zur Änderung ihrer Unterrichtspraxis nutzen. Aus Sicht von Bildungspolitik, Bildungsadministration und Bildungsforschung, die einer Evidenzbasierung pädagogischer Praxis zuarbeiten, kann ein solcher Umgang mit Forschungsergebnissen nicht als gelungen bewertet werden. Der Beitrag präsentiert eine Möglichkeit, wie sich die Nutzung von Forschungsergebnissen durch Lehrpersonen vertiefend analysieren lässt. Dazu wurde in einer Interviewstudie die Differenz von normativem und theoretischem Anspruch einerseits und dessen praktischer Umsetzung andererseits untersucht. Aufgegriffen wurde dabei die Leitdifferenz der Praxeologischen Wissenssoziologie, diejenige zwischen propositionaler und performativer Logik. Empirisch zeigen sich diese Logiken als Theorien von Lehrpersonen über Forschungsergebnisse einerseits, als Habitus der Gestaltung unterrichtlicher Interaktion andererseits. Es wird exemplarisch dargelegt, wie bestimmte Relationen von Theorien und Habitus eine Relevanzsetzung von Forschungsergebnissen durch Lehrpersonen verhindern bzw. ermöglichen.
Control of a 3-RRR Planar Parallel Robot Using Fractional Order PID Controller
Authors: Al-Mayyahi Auday , Aldair Ammar A. , Chatwin Chris 
Published: November 2020

Abstract3-RRR planar parallel robots are utilized for solving precise material-handling problems in industrial automation applications. Thus, robust and stable control is required to deliver high accuracy in comparison to the state of the art. The operation of the mechanism is achieved based on three revolute (3-RRR) joints which are geometrically designed using an open-loop spatial robotic platform. The inverse kinematic model of the system is derived and analyzed by using the geometric structure with three revolute joints. The main variables in our design are the platform base positions, the geometry of the joint angles, and links of the 3-RRR planar parallel robot. These variables are calculated based on Cayley-Menger determinants and bilateration to determine the final position of the platform when moving and placing objects. Additionally, a proposed fractional order proportional integral derivative (FOPID) is optimized using the bat optimization algorithm to control the path tracking of the center of the 3-RRR planar parallel robot. The design is compared with the state of the art and simulated using the Matlab environment to validate the effectiveness of the proposed controller. Furthermore, real-time implementation has been tested to prove that the design performance is practical.
Effective Solder for Improved Thermo-Mechanical Reliability of Solder Joints in a Ball Grid Array (BGA) Soldered on Printed Circuit Board (PCB)
Authors: Depiver Joshua A. , Mallik Sabuj , Amalu Emeka H. 
Published: November 2020

AbstractBall grid array (BGA) packages have increasing applications in mobile phones, disk drives, LC displays and automotive engine controllers. However, the thermo-mechanical reliability of the BGA solder joints challenges the device functionality amidst component and system miniaturisation as well as wider adoption of lead-free solders. This investigation determines the effective BGA solders for improved thermo-mechanical reliability of the devices. It utilised a conducted study on creep response of a lead-based eutectic Sn63Pb37 and four lead-free Tin–Silver–Copper (SnAgCu) [SAC305, SAC387, SAC396 and SAC405] solders subjected to thermal cycling loadings and isothermal ageing. The solders form the joints between the BGAs and printed circuit boards (PCBs). ANSYS R19.0 package is used to simulate isothermal ageing of some of the assemblies at − 40°C, 25°C, 75°C and 150°C for 45 days and model the thermal cycling history of the other assemblies from 22°C ambient temperature for six cycles. The response of the solders is simulated using the Garofalo-Arrhenius creep model. Under thermal ageing, SAC396 solder joints demonstrate possession of least strain energy density, deformation and von Mises stress in comparison to the other solders. Under thermal cycle loading conditions, SAC405 acquired the lowest amount of the damage parameters in comparison. Lead-free SAC405 and SAC387 joints accumulated the lowest and highest energy dissipation per cycle, respectively. It is concluded that SAC405 and SAC396 are the most effective solders for BGA in devices experiencing isothermal ageing and temperature cycling during operation, respectively. They are proposed as the suitable replacement of eutectic Sn63Pb37 solder for the various conditions.
Type 2 Diabetes Remission 5 Years After Laparoscopic Sleeve Gastrectomy: Multicenter Cohort Study
Authors: Mizera Magdalena , Wysocki Michał , Bartosiak Katarzyna , Franczak Paula , Hady Hady Razak , Kalinowski Piotr , Myśliwiec Piotr , Orłowski Michał , Paluszkiewicz Rafał , Piecuch Jerzy , Szeliga Jacek , Walędziak Maciej , Major Piotr , Pędziwiatr Michał 
Published: November 2020

AbstractPurposeBariatric surgery is no longer considered only as a weight loss surgery but also a way of treating obesity-related comorbidities such as type 2 diabetes mellitus (T2DM). Short-term T2DM remissions in patients undergoing laparoscopic sleeve gastrectomy (LSG) have been shown, but there are very few reports on the mid-term results. We aimed to assess the remission rate of T2DM in obese patients after LSG throughout 5-year follow-up.Materials and MethodologyWe performed a retrospective multicenter cohort analysis of 240 patients who underwent LSG. We assessed the remission rate of T2DM 1 year and 5 years after surgery.ResultsForty-six percent of patients achieved T2DM remission 5 years after LSG. The remission group had better weight loss results (median% of total weight loss 5 years after: 30.1% (22.9–37.0) vs 23.0% (13.7–30.2),p < 0.001) and were significantly younger than the no remission group (43 (38–52) vs 52 (44–58) years,p < 0.001). Duration of T2DM was significantly shorter (2 (1–5) vs 5 (3–10) years,p < 0.001) with less insulin requirement and less diabetes-related complications (7.2% vs 19.8%,p < 0.001) and significantly lower median DiaRem score (4.0 (IQR 2.0–6.0) vs 12.0 (IQR 5.0–16.0),p < 0.001). Preoperative body mass index (BMI) had no effect on remission.ConclusionsOur study suggests that diabetes remission after laparoscopic sleeve gastrectomy occurs frequently, and in the 5-year follow-up, it may remain at the level of 46%. We identified the age of patients, duration, and severity of T2DM as factors affecting mid-term diabetes remission. Nevertheless, further well-designed trials are needed to support our findings.
Robotic versus open oncological gastric surgery in the elderly: a propensity score-matched analysis
Authors: Garbarino Giovanni Maria , Costa Gianluca , Frezza Barbara , Biancafarina Alessia , Balducci Genoveffa , Mercantini Paolo , De Prizio Marco , Laracca Giovanni Gugliemo , Ceccarelli Graziano 
Published: November 2020

AbstractAlthough there is no agreement on a definition of elderly, commonly an age cutoff of ≥ 65 or 75 years is used. Even if robot-assisted surgery is a validated option for the elderly population, there are no specific indications for its application in the surgical treatment of gastric cancer. The aim of this study is to evaluate the safety and feasibility of robot-assisted gastrectomy and to compare the short and long-term outcomes of robot-assisted (RG) versus open gastrectomy (OG). Patients aged ≥ 70 years old undergoing surgery for gastric cancer at the Department of Surgery of San Donato Hospital in Arezzo, between September 2012 and March 2017 were enrolled. A 1:1 propensity score matching was performed according to the following variables: age, Sex, BMI, ASA score, comorbidity, T stage and type of resection performed. 43 OG were matched to 43 RG. The mean operative time was significantly longer in the RG group (273.8 vs. 193.5 min, p < 0.01). No differences were observed in terms of intraoperative blood loss, an average number of lymph nodes removed, mean hospital stay, morbidity and mortality. OG had higher rate of major complications (6.9 vs. 16.3%, OR 2.592, 95% CI 0.623–10.785, p = 0.313) and a significantly higher postoperative pain (0.95 vs. 1.24, p = 0.042). Overall survival (p = 0.263) and disease-free survival (p = 0.474) were comparable between groups. Robotic-assisted surgery for oncological gastrectomy in elderly patients is safe and effective showing non-inferiority comparing to the open technique in terms of perioperative outcomes and overall 5-year survival.
How young companies can effectively manage their slack resources over time to ensure sales growth: the contingent role of value-based selling
Authors: de Jong Ad , Zacharias Nicolas A. , Nijssen Edwin J. 
Published: November 2020

AbstractThis research aims to bridge the entrepreneurship and marketing/sales literature streams by studying how young firms enable their resource endowments using value-based selling. Drawing on effectuation logic, the authors examine how young firms can achieve sales growth by using human and financial resource slack during the early years of their existence and accounting for the impact of the variability of these resources over time. The integrated framework and hypotheses are tested using unique, multisource (survey and objective archival) longitudinal panel data from 71 young firms covering a seven-year period. As anticipated, the findings show that both financial and human resource slack are negatively related to young firms’ sales growth over time and that financial resource slack variability exerts a positive impact and human resource slack variability exerts a (nonsignificant) negative impact. The results also confirm the importance of value-based selling as a guiding mechanism that significantly alters the effects of both types of resource slack and their variability over time. While value-based selling can help a young firm use slack to grow more effectively, it also has a dark side in that it can stand in the way of risk taking.
Organic Electrode Materials for Non-aqueous K-Ion Batteries
Authors: Wang Mingtan , Lu Wenjing , Zhang Huamin , Li Xianfeng 
Published: November 2020

AbstractThe demands for high-performance and low-cost batteries make K-ion batteries (KIBs) considered as promising supplements or alternatives for Li-ion batteries (LIBs). Nevertheless, there are only a small amount of conventional inorganic electrode materials that can be used in KIBs, due to the large radius of K+ions. Differently, organic electrode materials (OEMs) generally own sufficiently interstitial space and good structure flexibility, which can maintain superior performance in K-ion systems. Therefore, in recent years, more and more investigations have been focused on OEMs for KIBs. This review will comprehensively cover the researches on OEMs in KIBs in order to accelerate the research and development of KIBs. The reaction mechanism, electrochemical behavior, etc., of OEMs will all be summarized in detail and deeply. Emphasis is placed to overview the performance improvement strategies of OEMs and the characteristic superiority of OEMs in KIBs compared with LIBs and Na-ion batteries.
Der Tumormarker Sialinsäure
Authors: Passek K. , Bendels M. H. , Ohlendorf D. , Oremek G. M. 
Published: November 2020

ZusammenfassungDie vorliegende Übersicht zum Tumormarker Sialinsäure wird im Rahmen der Serie „Tumormarker“ des Zentralblatts für Arbeitsmedizin, Arbeitsschutz und Ergonomie publiziert, die sich mit dem immer häufigeren Gebrauch der Bestimmung von spezifischen Markern bei sog. Manager-Vorsorgen und Check-up-Untersuchungen beschäftigt. Sialinsäure eignet sich grundsätzlich nicht für solche Vorsorgen, sondern ist ein Marker zur Therapie‑, Verlaufs- und Rezidivkontrolle von Mundhöhlenkarzinomen. Hier zeigt dieser eine hohe Sensitivität und Spezifität, wobei der Marker aber auf keinen Fall als Screeningparameter zur Frühdiagnostik eingesetzt werden soll.
Printable Zinc-Ion Hybrid Micro-Capacitors for Flexible Self-Powered Integrated Units
Authors: Zeng Juan , Dong Liubing , Sun Lulu , Wang Wen , Zhou Yinhua , Wei Lu , Guo Xin 
Published: November 2020

AbstractWearable self-powered systems integrated with energy conversion and storage devices such as solar-charging power units arouse widespread concerns in scientific and industrial realms. However, their applications are hampered by the restrictions of unbefitting size matching between integrated modules, limited tolerance to the variation of input current, reliability, and safety issues. Herein, flexible solar-charging self-powered units based on printed Zn-ion hybrid micro-capacitor as the energy storage module is developed. Unique 3D micro-/nano-architecture of the biomass kelp-carbon combined with multivalent ion (Zn2+) storage endows the aqueous Zn-ion hybrid capacitor with high specific capacity (196.7 mAh g−1 at 0.1 A g−1). By employing an in-plane asymmetric printing technique, the fabricated quasi-solid-state Zn-ion hybrid micro-capacitors exhibit high rate, long life and energy density up to 8.2 μWh cm−2. After integrating the micro-capacitor with organic solar cells, the derived self-powered system presents outstanding energy conversion/storage efficiency (ηoverall = 17.8%), solar-charging cyclic stability (95% after 100 cycles), wide current tolerance, and good mechanical flexibility. Such portable, wearable, and green integrated units offer new insights into design of advanced self-powered systems toward the goal of developing highly safe, economic, stable, and long-life smart wearable electronics.
m6A Regulates Liver Metabolic Disorders and Hepatogenous Diabetes
Authors: Li Yuhuan , Zhang Qingyang , Cui Guanshen , Zhao Fang , Tian Xin , Sun Bao-Fa , Yang Ying , Li Wei 
Published: November 2020

Abstract
N 6-methyladenosine (m6A) is one of the most abundant modifications on mRNAs and plays important roles in various biological processes. The formation of m6A is catalyzed by a methyltransferase complex (MTC) containing a key factor methyltransferase-like 3 (Mettl3). However, the functions of Mettl3 and m6A modification in hepatic lipid and glucose metabolism remain unclear. Here, we showed that both Mettl3 expression and m6A level increased in the livers of mice with high fat diet (HFD)-induced metabolic disorders. Overexpression of Mettl3 aggravated HFD-induced liver metabolic disorders and insulin resistance. In contrast, hepatocyte-specific knockout of Mettl3 significantly alleviated HFD-induced metabolic disorders by slowing weight gain, reducing lipid accumulation, and improving insulin sensitivity. Mechanistically, Mettl3 depletion-mediated m6A loss caused extended RNA half-lives of metabolism-related genes, which consequently protected mice against HFD-induced metabolic syndrome. Our findings reveal a critical role of Mettl3-mediated m6A in HFD-induced metabolic disorders and hepatogenous diabetes.
“The perfect breast”: Measuring cosmetic outcomes after breast-conserving therapy
Authors: James J. , Ip E. , Hong A. , Stoney D. , Law M. 
Published: November 2020

ABSTRACT

Background:
Measuring cosmetic outcome following breast-conserving therapy (BCT) is difficult. However, it is crucial to have an easy-to-use and reproducible method to record this outcome of BCT. We argue that breast cosmesis can be divided into a set of key cosmetic components that are easy to observe and score individually, and the total score synthesised from these component scores can reflect the overall cosmesis. Additionally, this system would also indicate the cause for the aesthetic deficiency. We report our experience using a cosmetic score based on six determinants of breast aesthetics, namely breast size, breast contour, vertical nipple position, horizontal nipple position, breast skin appearance, and scar appearance.

Materials and methods:
In this prospective study, our assessors scored 112 patients who had undergone BCT six or more months previously, by using our Total Cosmetic Score (TCS) instrument. An Overall Cosmetic Grade (OCG) of the breast was then compared against the TCS.

Results:
We found a very good agreement between total aesthetic score and overall cosmetic grade.

Conclusion:
A simple subscale based cosmetic scoring system is a practical method of documenting and rating the cosmetic outcome of BCT.

Highlights:
The Association of Dexmedetomidine with Firing Properties in Pallidal Neurons
Authors: Gasim Majid , Kalia Suneil K. , Hodaie Mojgan , Lozano Andres M. , Venkatraghavan Lakshmikumar , Hutchison William D. 
Published: November 2020

Abstract:Background:Microelectrode recordings (MERs) are used during deep brain stimulation surgery (DBS) to optimize patient outcomes and provide a unique method of collecting data regarding neurological conditions. However, MERs can be affected by anesthetics such as dexmedetomidine. Little is known about the effects of dexmedetomidine (DEX) on the globus pallidus interna (GPi), a common target for DBS. The primary aim of this study is to investigate the hypothesis that DEX is associated with alterations in GPi MERs.Methods:We conducted a retrospective analysis comparing MERs from patients with Parkinson’s disease (PD) and dystonia who underwent insertion of DBS of the GPi under DEX sedation with those who went through the same procedure without DEX (No DEX).Results:Firing rates for GPi neurons in the DEX group were lower (57.44 ± 2.04; mean ± SEM, n = 163 cells) than the No DEX group (69.53 ± 2.06, n = 112 cells, P < 0.0001). Overall, DEX was associated with a greater proportion of GPi cells classified as firing in bursty pattern compared to our No DEX group. (29.41%, n = 153 vs 14.81%, n = 108, P = 0.008). This effect was present for both PD and dystonia patients who underwent the procedure. High doses of DEX were associated with lower firing rates than low doses.Conclusions:Our results suggest that DEX is associated with a decrease in GPi firing rates and are associated with an increase in burstiness. Furthermore, these effects are similar between dystonia and PD patients. Lastly, the effects of DEX may differ between high doses and low doses.
REVEALING CONTINGENCY THROUGH SHUN'S 舜 ASCENSION TO THE THRONE
Authors: Back Youngsun 
Published: November 2020

AbstractThis article examines the story of Shun's 舜 ascension to the throne. This story has drawn considerable attention throughout Chinese history because of its significance with regard to political succession. However, in this article, I shed light on a different dimension of the story: its relevance to the issue of contingency. I investigate four texts, two excavated and two transmitted: Qiongda yi shi 窮達以時 (Failure and Success Depend on Times), Tang Yu zhi dao 唐虞之道 (The Way of Yao and Shun), the Mengzi 孟子, and the Xunzi 荀子. At one extreme, Qiongda yi shi highlights that Shun became a king by pure chance, while at the other extreme, Xunzi interprets the event as a necessary one, emphasizing that Shun cannot but succeed Yao. The other two texts fall somewhere in between the two extremes. I use these four texts to showcase different ways of thinking about areas over which humans are believed to lack control. My claim is that these four texts offer different accounts of the same event—Shun's ascension—because they see the event from different perspectives: from a perspective of the chosen, from a perspective of the chooser, from a mise-en-scène, and from a perspective of not of this world, respectively. I argue that the diverse perspectives of these texts entail the different understandings of several related issues such as the degree of human control over the event, the important features of the event, and the content of the moral and political lessons that we draw from the event.
WHAT THE ELITES ACTUALLY WORE IN 500–300 B.C.E. CHINA: EVIDENCE FROM TEXTILES, BAMBOO, AND BRONZES
Authors: Li Kin Sum (Sammy) 
Published: November 2020

AbstractThis article uses evidence from textiles, bamboo, and bronzes to explore what the elites wore, who made up the design communities behind the elites, and how luxurious these items were considered to be in 500–300b.c.e.China. It first examines the reliability of the art historical sources available for the reconstruction of this history and cautions the readers against certain past interpretations of the textiles and accessories of the period. It then delineates a brief history of how certain textile patterns and weaving techniques developed and how their producers selected and obtained sources of inspiration and interacted and exchanged ideas with producers of other types of artifacts. It argues that textile designers seemed to favor certain types of sources and had formed their own distinct, though not impervious, community. After carefully examining the weaving techniques of several pieces of fabric, it proposes a means of building a more reliable and solid foundation for art historical reconstruction. Textiles and accessories were symbols of the wealth, status, and power of individuals who wore them. This article will explain how a combination of the production techniques of textiles and accessories, together with a sharing of designs and techniques within the community of producers, contributed to the formation of those symbols.
The challenge of engaging with and reporting against the SDGs for SMEs such as Sydney Theatre Company
Authors: Dalton Valerie 
Published: November 2020

AbstractThe UN Sustainable Development Goals to 2030 call for action by the globe to tackle some of the most pressing problems facing humanity. There is a key role for business in helping to meet the goals, and in particular, small- to medium-sized enterprises (SMEs), which account for over 90% of global businesses. Many organisations that were already engaged in addressing sustainability prior to the release of the SDGs will need to shift their approach to accommodate the new framework, including SMEs like Sydney Theatre Company (STC). This paper explores the use of the SDG Compass as a tool for making that shift by revisiting a previous case study on STC's sustainability journey since 2008 to assess the efficacy of the SDG Compass as a guide to addressing the SDGs. It finds that the SDG Compass is prohibitively complex for SMEs which could impede engagement with the SDGs by SMEs.