bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19: Behandlungsstrategien der deutschsprachigen Kinderrheumatologen
Authors: Janda A. , Schuetz C. , Heeg M. , Minden K. , Hedrich C. M. , Kallinich T. , Hinze C. , Schulz A. , Speth F. 
Published: August 2020

ZusammenfassungHintergrundZuverlässige Daten zu Verlauf und Therapie von COVID-19 („corona virus disease 2019“) bei Kindern mit rheumatischen Erkrankungen unter Immunsuppression fehlen.Ziel der ArbeitAbbildung individueller Strategien der Mitglieder der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR) im Umgang mit COVID-19.MethodikMittels Online-Umfrage wurden im Mai 2020 das Meinungsbild der GKJR-Mitglieder zum Umgang mit DMARDs („disease-modifying anti-rheumatic drugs“) bei COVID-19-Erkrankung sowie die Bereitschaft zum Einsatz spezieller Therapieansätze bei Patienten mit unterschiedlicher Schwere von COVID-19 erhoben.ErgebnisseEs nahmen 71 Kollegen (27,3 % aller befragten ärztlichen Mitglieder) an der Umfrage teil; davon hatten 28,2 % bereits Patienten mit COVID-19 betreut. Über 95 % der Teilnehmer lehnten eine präventive Anpassung der antirheumatischen Therapie im Rahmen der SARS-CoV-2-Pandemie ab. Bei ambulanten Patienten unter Immunsuppression mit nachgewiesener COVID-19-Erkrankung würden mehr als 50 % der Teilnehmer folgende Therapien aussetzen: intravenöse hoch dosierte Steroide, Cyclophosphamid, Anti-CD20-Antikörper, sowie eine BAFF-, CTLA-4-, TNF-α-Blockade. Hingegen würden nichtsteroidale Antiphlogistika, Hydroxychloroquin (HCQ), orale Steroide, Mycophenolat, IL-1-Blockade sowie Immunglobuline (Ig) von >70 % der Kollegen weiter fortgeführt. Bei stationären Patienten mit COVID-19 würden insgesamt 74,6 % der Kollegen eine COVID-19-gerichtete Therapie erwägen. Bei stabilem Verlauf unter O2-Therapie (Stufe I) würden am häufigsten HCQ (18,3 %), Azithromycin (16,9 %) und Ig (9,9 %) in Betracht gezogen. Bei drohendem (Stufe II) bzw. manifestem Zytokinsturm (Stufe III) würden am häufigsten Anakinra (40,8 % bei Stufe II bzw. 46,5 % bei Stufe III), Tocilizumab (26,8 % bzw. 40,8 %), Steroide (25,4 % bzw. 33,8 %) und Remdesivir (29,6 % bzw. 38,0 %) eingesetzt. Von vielen Kollegen wurde betont, dass die Therapiestrategie individuell und der klinischen Situation entsprechend angepasst werden soll.DiskussionDie Ergebnisse der Online-Umfrage sind vor dem Hintergrund einer aktuell in Deutschland niedrigen Prävalenz von COVID-19 zu sehen und spiegeln somit theoretische Überlegungen der Befragten wider. Da Kinder derzeit nicht im Fokus von prospektiven COVID-19-Studien stehen, scheint der kontinuierliche und kritische kollegiale Fachaustausch bei Therapieentscheidungen umso wichtiger zu sein.
An unpublished manuscript of John von Neumann on shock waves in boostered detonations: historical context and mathematical analysis
Authors: Knoedler Molly Riley , Kostas Julianna C. , Hogan Caroline Mary , Kerkhoff Harper , Topaz Chad M. 
Published: August 2020

AbstractWe report on an unpublished and previously unknown manuscript of John von Neumann and contextualize it within the development of the theory of shock waves and detonations during the nineteenth and twentieth centuries. Von Neumann studies bombs comprising a primary explosive charge along with explosive booster material. His goal is to calculate the minimal amount of booster needed to create a sustainable detonation, presumably because booster material is often more expensive and more volatile. In service of this goal, he formulates and analyzes a partial differential equation-based model describing a moving shock wave at the interface of detonated and undetonated material. We provide a complete transcription of von Neumann’s work and give our own accompanying explanations and analyses, including the correction of two small errors in his calculations. Today, detonations are typically modeled using a combination of experimental results and numerical simulations particular to the shape and materials of the explosive, as the complex three dimensional dynamics of detonations are analytically intractable. Although von Neumann’s manuscript will not revolutionize our modern understanding of detonations, the document is a valuable historical record of the state of hydrodynamics research during and after World War II.
Towards early disease modification of Parkinson’s disease: a review of lessons learned in the Alzheimer field
Authors: Smedinga Marthe , Darweesh Sirwan K. L. , Bloem Bastiaan R. , Post Bart , Richard Edo 
Published: August 2020

AbstractParkinson’s disease (PD) research is beginning to focus on early disease modification and prevention. The therapeutic pipeline includes a growing range of pharmacological interventions that could theoretically intervene with the underlying disease process. It is hoped that applying such interventions in a very early stage of the disease pathology, before the onset of motor symptoms or during its early stages, may prevent or delay further disease progression. To identify people in this early disease stage, criteria for ‘prodromal PD’ have been proposed—describing people with one or more specific features that jointly constitute a variably increased risk of developing clinically manifest PD. Here, we aim to draw lessons from the field of Alzheimer’s research, which has followed a similar strategy over the last decade, including the expansion of the disease label to ‘prodromal’ stages. Importantly, none of the large and costly randomized-controlled trials aiming to slow down or prevent Alzheimer’s dementia by targeting the alleged disease pathology, i.e., amyloid-β aggregation, resulted in detectable clinical effects. Lack of sufficiently robust phase 2 trial results before moving to phase 3 studies, suboptimal participant selection, insensitive outcomes, a too narrow target focus, and trial design flaws contributed to this disappointing outcome. We discuss the various similarities between these Alzheimer’s and PD approaches, and review the design of prevention or early disease modification trials for both diseases including the potential for immunotherapy. Finally, we offer considerations to optimize the design of such trials in PD, benefiting from the lessons learned in Alzheimer’s prevention research.
The structure-based reaction mechanism of urease, a nickel dependent enzyme: tale of a long debate
Authors: Mazzei Luca , Musiani Francesco , Ciurli Stefano 
Published: August 2020

AbstractThis review is an attempt to retrace the chronicle that starts from the discovery of the role of nickel as the essential metal ion in urease for the enzymatic catalysis of urea, a key step in the biogeochemical cycle of nitrogen on Earth, to the most recent progress in understanding the chemistry of this historical enzyme. Data and facts are presented through the magnifying lenses of the authors, using their best judgment to filter and elaborate on the many facets of the research carried out on this metalloenzyme over the years. The tale is divided in chapters that discuss and describe the results obtained in the subsequent leaps in the knowledge that led from the discovery of a biological role for Ni to the most recent advancements in the comprehension of the relationship between the structure and function of urease. This review is intended not only to focus on the bioinorganic chemistry of this beautiful metal-based catalysis, but also, and maybe primarily, to evoke inspiration and motivation to further explore the realm of bio-based coordination chemistry.
A novel method for alveolar bone grafting assessment in cleft lip and palate patients: cone-beam computed tomography evaluation
Authors: Stasiak Marcin , Wojtaszek-Słomińska Anna , Racka-Pilszak Bogna 
Published: August 2020

Abstract
Objectives
This retrospective cross-sectional study aimed to present a new method for secondary alveolar bone grafting (SABG) assessment and to qualitatively evaluate the SABG results in unilateral cleft lip and palate patients.

Materials and methods
Research was conducted according to the STROBE guidelines. The study group consisted of 21 patients with a mean age of 16 years. High-resolution cone-beam computed tomography (CBCT) was performed at least 1 year after grafting. The experimental side was the cleft side, and the contralateral side without a congenital cleft was the control. Measurements were performed at four levels of the maxillary central incisors’ roots according to the new scale with scores from 0 to 3. The sum of the scores provided a general assessment of bone architecture. The Wilcoxon signed-rank test was used for intergroup comparisons, and a Kappa coefficient was used for reproducibility measurements.

Results
High individual variability was found, and the bone architecture was significantly worse on the cleft side than on the noncleft side. The results showed 28.57% failure, 33.33% poor, 19.05% moderate, and 19.05% good results from the surgical procedure. Kappa coefficients produced results from 0.92 to 1.00 for intra-rater and from 0.81 to 1.00 for inter-rater reproducibility.

Conclusions
CBCT provides detailed information about alveolar bone morphology. The new assessment method is useful at every treatment stage and provides excellent repeatability. SABG did not provide good bone morphology, in most cases.

Clinical relevance
This research presents a new universal alternative for the assessment of SABG by utilizing CBCT.
Intestinal hypomotility in systemic sclerosis: a histological study into the sequence of events
Authors: den Braber-Ymker M. , Vonk M. C. , Grünberg K. , Lammens M. , Nagtegaal I. D. 
Published: August 2020

Abstract
Objectives
The pathogenesis of intestinal involvement in systemic sclerosis (SSc) is thought to be a sequential process (vascular, neuronal, and consecutive muscular impairment), but understanding of the underlying histological changes and how they translate to symptoms, is still lacking. Therefore, we systematically investigated histological characteristics of SSc in the intestines, compared to controls.

Methods
Autopsy material from the small bowel and colon was used for histological semiquantitative evaluation of the vasculature, enteric nervous system, interstitial cells of Cajal (ICC), and muscle layers, using a combination of histochemical and immunohistochemical stainings, according to guidelines of the Gastro 2009 International Working Group.

Results
Vascular changes were most frequently encountered, represented by intima fibrosis in both arteries and small vessels, and represented by venous dilatation. Second, generalized fibrosis of the circular muscle layer was significantly more found in SSc patients than in controls. Third, reduction of submucosal nerve fibers and myenteric neurons was shown in the colon of four SSc patients, which may explain severe symptoms of intestinal dysmotility. The density of myenteric ICC network was decreased in the small bowel of SSc patients.

Conclusions
The postulated sequential processes of intestinal involvement in SSc could not be supported by our histological evaluation. The interpatient diversity suggests that parallel processes occur, explaining the variety of histological features and clinical symptoms.

Key Points• Histological analysis showed vascular changes, fibrosis in the muscularis propria, and reduction of the ENS and ICC network in the intestines of SSc patients.• Pathophysiological mechanisms leading to intestinal dysmotility in SSc may be parallel rather than sequential.• The interpatient diversity suggests parallel pathophysiological processes, explaining the variety of histological features and clinical symptoms.
Brainstem auditory evoked potentials in patients with primary Sjögren’s syndrome without central nervous system involvement
Authors: Waliszewska-Prosół Marta , Sebastian Agata , Wiland Piotr , Budrewicz Sławomir , Dziadkowiak Edyta , Ejma Maria 
Published: August 2020

Abstract
Objectives
Primary Sjögren’s syndrome (pSS) is an autoimmune, multisystem exocrinopathy characterized by dysfunction of the exocrine glands. Central nervous system (CNS) involvement is estimated to be present in 10–60% patients with pSS. The present study aimed to evaluate brainstem auditory evoked potentials (BAEP) in pSS patients without central nervous system involvement, and without otolaryngological abnormalities.

Method
Thirty-six pSS patients (35 women, 1 man, mean age 48 years old) and 40 healthy volunteers were investigated. BAEP, brain imaging, laboratory parameters, and clinical neurological and otolaryngological examinations were performed.

Results
Abnormal BAEP were recorded in 16.7% patients. The mean wave BAEP I and V latency and mean wave III-V and I-V interpeak latencies were significantly longer in pSS patients than the controls. There were no statistically significant correlations between BAEP parameters and laboratory tests. None of the patients was found having the abnormalities on brain imaging.

Conclusions
This study confirms that in pSS patients without clinical central nervous system impairment, auditory pathway disturbances could be found. Disorders of brain bioelectrical activity may be a consequence of ongoing autoimmune process.

Key Points• BAEP abnormalities confirmed the clinically observed involvement of the central nervous system in patients with pSS.• Brain bioelectrical activity dysfunctions in pSS patients may be a consequence of ongoing inflammatory and/or immunological processes.
A comprehensive and cost-effective approach for investigating passive dispersal in minute invertebrates with case studies of phytophagous eriophyid mites
Authors: Kuczyński Lechosław , Radwańska Anna , Karpicka-Ignatowska Kamila , Laska Alicja , Lewandowski Mariusz , Rector Brian G. , Majer Agnieszka , Raubic Jarosław , Skoracka Anna 
Published: August 2020

AbstractDispersal is a fundamental biological process that operates at different temporal and spatial scales with consequences for individual fitness, population dynamics, population genetics, and species distributions. Studying this process is particularly challenging when the focus is on microscopic organisms that disperse passively, whilst controlling neither the transience nor the settlement phase of their movement. In this work we propose a comprehensive approach for studying passive dispersal of microscopic invertebrates and demonstrate it using wind and phoretic vectors. The protocol includes the construction of versatile, modifiable dispersal tunnels as well as a theoretical framework quantifying the movement of species via wind or vectors, and a hierarchical Bayesian approach appropriate to the structure of the dispersal data. The tunnels were used to investigate the three stages of dispersal (viz., departure, transience, and settlement) of two species of minute, phytophagous eriophyid mites Aceria tosichella and Abacarus hystrix. The proposed devices are inexpensive and easy to construct from readily sourced materials. Possible modifications enable studies of a wide range of mite species and facilitate manipulation of dispersal factors, thus opening a new important area of ecological study for many heretofore understudied species.
A small cichlid species flock from the Upper Miocene (9–10 MYA) of Central Kenya
Authors: Altner Melanie , Reichenbacher Bettina 
Published: August 2020

AbstractFossil cichlids from East Africa offer unique insights into the evolutionary history and ancient diversity of the family on the African continent. Here we present three fossil species of the extinct haplotilapiine cichlid †Baringochromis gen. nov. from the upper Miocene of the palaeolake Waril in Central Kenya, based on the analysis of a total of 78 articulated skeletons. †Baringochromis senutae sp. nov., †B. sonyii sp. nov. and †B. tallamae sp. nov. are superficially similar, but differ from each other in oral-tooth dentition and morphometric characters related to the head, dorsal fin base and body depth. These findings indicate that they represent an ancient small species flock. Possible modern analogues of palaeolake Waril and its species flock are discussed. The three species of †Baringochromis may have begun to subdivide their initial habitat by trophic differentiation. Possible sources of food could have been plant remains and insects, as their fossilized remains are known from the same place where †Baringochromis was found.
Expression and Clinical Significance of Mucin Gene in Chronic Rhinosinusitis
Authors: Tong Jiaxin , Gu Qingjia 
Published: August 2020

Abstract
Purpose of Review
This review highlights the expression and regulation of mucin in CRS and discusses its clinical implications.

Recent Findings
Chronic rhinosinusitis (CRS) is common chronic nasal disease; one of its main manifestations and important features is mucus overproduction. Mucin is the major component of mucus and plays a critical role in the pathophysiological changes in CRS. The phenotype of CRS affects the expression of various mucins, especially in nasal polyps (NP). Corticosteroids(CS), human neutrophil elastase (HNE), and transforming growth factor-β1 (TGF-β1) are closely related to the tissue remodeling of CRS and regulate mucin expression, mainly MUC1, MUC4, MUC5AC, and MUC5B. “It is expected that CS, HNE and TGF - β could be used to regulate the expression of mucin in CRS.” However, at present, the research on mucin is mainly focused on mucin 5AC and mucin 5B, which is bad for finding new therapeutic targets.

Summary
Investigating the expression and location of mucin in nasal mucosa and understanding the role of various inflammatory factors in mucin expression are helpful to figure out regulatory mechanisms of airway mucin hypersecretion. It is of great significance for the treatment of CRS.
The Joubert Syndrome Gene arl13b is Critical for Early Cerebellar Development in Zebrafish
Authors: Zhu Jian , Wang Han-Tsing , Chen Yu-Rong , Yan Ling-Ya , Han Ying-Ying , Liu Ling-Yan , Cao Ying , Liu Zhi-Zhi , Xu Hong A. 
Published: August 2020

AbstractJoubert syndrome is characterized by unique malformation of the cerebellar vermis. More than thirty Joubert syndrome genes have been identified, includingARL13B. However, its role in cerebellar development remains unexplored. We found that knockdown or knockout ofarl13bimpaired balance and locomotion in zebrafish larvae. Granule cells were selectively reduced in the corpus cerebelli, a structure homologous to the mammalian vermis. Purkinje cell progenitors were also selectively disturbed dorsomedially. The expression ofatoh1andptf1, proneural genes of granule and Purkinje cells, respectively, were selectively down-regulated along the dorsal midline of the cerebellum. Moreover,wnt1, which is transiently expressed early in cerebellar development, was selectively reduced. Intriguingly, activating Wnt signaling partially rescued the granule cell defects inarl13bmutants. These findings suggested that Arl13b is necessary for the early development of cerebellar granule and Purkinje cells. Thearl13b-deficient zebrafish can serve as a model organism for studying Joubert syndrome.
Classification and improvement of the flow condition with spatial distribution in unsaturated soil
Authors: Sato Mari 
Published: August 2020

AbstractSeepage flow in unsaturated soil cannot be accurately calculated or measured using existing theories, as they consider several assumptions, and associated simulations are conducted under ideal conditions. Exact values such as velocity and pressure inside the unsaturated ground are not obvious that are often estimated by the seepage flow analysis. Those estimated values are not often corresponded to the measured values well. This study aimed to re-evaluate the conditions that well-known theories are established without any failures and aim to reduce the inconsistency for numerical analysis. Concretely, it develops a simple method to judge the inconsistency of well-known theories on geotechnical engineering in unsaturated soil by utilizing the fundamental magnitude relations of several properties and velocity terms in Bernoulli’s principle. As a result, consistent and inconsistent conditions are classified, although it is estimated that continuous seepage ranges close to the piezometric head conservation equation: h = z + ψ. The classification by this judgement is contributed to the estimation of the ground seepage condition using the combination of pressure head and hydraulic head difference in practical sites. Moreover, the inconsistency can be solved by assuming the local hydraulic gradient distributions. The hydraulic gradient modification is proposed by installing tentative seepage length and tentative hydraulic head for flow analysis. Finally, the local hydraulic gradient led by the proposed equations is calculated with the Mualem–van Genuchten model; the calculation results show the modified local hydraulic gradient is valid and applicable. Future works include discretization and analytical method. The criterion can immediately judge whether ground conditions and modification methods can be used for a more accurate seepage analysis in unsaturated soil.
Classification of the Paleoproterozoic Gulcheru Formation: Implications on Early Paleogeographic and Tectonic Evolution of the Cuddapah Basin, India
Authors: Majumder Tuasha , Patranabis-Deb Sarbani 
Published: August 2020

Abstract
The Papaghni sub-basin of the Cuddapah basin is an arcuate NW-SE trending intracratonic basin, stretching from Kurnool in the NW to Guvvalacheruvu in the SE, in southern peninsular India. Despite of large number of researches, an understanding of the evolution of the basin is still elusive. The sub-basin preserves records of repeated opening and closing of Paleoproterozoic rifts along the zone of NW-SE trending axis in the East Dharwar craton. Present study was carried out along the southwestern margin of the Papaghni sub-basin, in and around Tadpatri-Gooty-Dhone area, where the successive litho-units are represented by two major unconformity-bound sequences. Each of these sequences are characterized by a distinctive set of litho-assemblage, deposited under diverse tectonic environments with highly variable modes and tempos of sedimentation in an extensional basin. The basin initiated at about 2 Ga and shortly evolved into a shallow sea, with development of wide siliciclastic shelf in an open marine condition, the Gulcheru Formation. Gradually, with time the siliciclastic shelf was replaced by an extensive stromatolitic carbonate platform, the Vempalle Formation. Dedicated fieldwork exemplifies that the initial basin-fill is characterized largely by several cycles of simple, but amalgamated and stacked fanglomerates (alluvial fan to fan-delta) systems developed from several single stream breaches onto the proximal setting of the basin, in a syn-rift setting. These fanglomerates display a fining upward sequence, which progressively passes up to high-energy coastal, tide-storm dominated shelf environments of post-rift setting. This study justifies the subdivision of the Gulcheru Formation into two formal lithostratigraphic members, the Daditota Member and the Karvipalle Member. The Daditota Member directly overlies the granitoid basement and grades upward to Karvipalle Member. Karvipalle Member, comprising predominantly of medium to fine-grained, reddish brown and white quartz arenites of stable shelf deposits, distinctly differs from the conglomerate and very coarse-grained mass-flow dominated deposits of the Daditota Member. The Vempalle Formation overlies the Gulcheru Formation with a gradational contact and consists of stromatolitic dolomite, oolite and shale, developed in a ramp type carbonate platform setting. Gradual transition from siliciclastic to carbonate sequence points to passive margin setting developed during the breakup of the supercontinent Kenorland. Disposition of proximal to distal sequences and northeastern, eastern and southeastern paleocurrent of the sequences advocate a NW-SE shoreline and eastern paleo-slope of the basin.