bluuebunny/crossref_metadata_2025_split huggingface dataset:
Young adults' partner preferences and parents' in‐law preferences across generations, genders, and nations
Authors: Locke Kenneth D. , Mastor Khairul A. , MacDonald Geoff , Barni Daniela , Morio Hiroaki , Reyes Jose Alberto S. , Vargas‐Flores José de Jesús , Ibáñez‐Reyes Joselina , Kamble Shanmukh , Ortiz Fernando A. 
Published: January 2020

AbstractTo examine cultural, gender, and parent–child differences in partner preferences, in eight countries undergraduates (n = 2,071) and their parents (n = 1,851) ranked the desirability of qualities in someone the student might marry. Despite sizable cultural differences—especially between Southeast Asian and Western countries—participants generally ranked kind/understanding (reflecting interpersonal communion) highest, and intelligent and healthy (reflecting mental/physical agency) among the top four. Students valued exciting, attractive partners more and healthy, religious partners less than parents did; comparisons with rankings by youth in 1984 (i.e., from the parents' generation) suggested cohort effects cannot explain most parent–child disagreements. As evolutionary psychology predicts, participants prioritized wives' attractiveness and homemaker skills and husbands' education and breadwinner skills; but as sociocultural theory predicts, variations across countries/decades in gendered spousal/in‐law preferences mirrored socioeconomic gender differences. Collectively, the results suggest individuals consider their social roles/circumstances when envisioning their ideal spouse/in‐law, which has implications for how humans’ partner‐appraisal capabilities evolved.
Discovery and identification of medium‐chain fatty acid responsive promoters in Saccharomyces cerevisiae
Authors: Han Li , Han Danya , Li Lei , Huang Shen , He Peixin , Wang Qinhong 
Published: January 2020

AbstractMedium‐chain fatty acids (MCFAs) and their derivatives are important chemicals that can be used in lubricants, detergents, and cosmetics. MCFAs can be produced in several microbes, although production is not high. Dynamic regulation by synthetic biology is a good method of improving production of chemicals that avoids toxic intermediates, but chemical‐responsive promoters are required. Several MCFA sensors or promoters have been reported in Saccharomyces cerevisiae. In this study, by using transcriptomic analysis of S. cerevisiae exposed to fatty acids with 6‐, 12‐, and 16‐carbon chains, we identified 58 candidate genes that may be responsive to MCFAs. Using a fluorescence‐based screening method, we identified MCFA‐responsive promoters, four that upregulated gene expression, and three that downregulated gene expression. Dose–response analysis revealed that some of the promoters were sensitive to fatty acid concentrations as low as 0.02–0.06 mM. The MCFA‐responsive promoters reported in this study could be used in dynamic regulation of fatty acids and fatty acid‐derived products in S. cerevisiae.
Watershed and ocean controls of salt marsh extent and resilience
Authors: Yousefi Lalimi Fateme , Marani Marco , Heffernan James Brendan , D'Alpaos Andrea , Murray A. Brad 
Published: January 2020

AbstractThe formation and evolution of tidal platforms are controlled by the feedbacks between hydrodynamics, geomorphology, vegetation, and sediment transport. Previous work mainly addresses dynamics at the scale of individual marsh platforms. Here, we develop a process‐based model to investigate salt marsh depositional/erosional dynamics and resilience to environmental change at the scale of tidal basins. We evaluate how inputs of water and sediment from river and ocean sources interact, how losses of sediment to the ocean depend on this interaction, and how erosional/depositional dynamics are coupled to these exchanges. Model experiments consider a wide range of watershed, basin, and oceanic characteristics, represented by river discharge and suspended sediment concentration, basin dimensions, tidal range, and ocean sediment concentration. In some scenarios, the vertical accretion of a tidal flat can be greater than the rate of sea level rise. Under these conditions, vertical depositional dynamics can lead to transitions between tidal flat and salt marsh equilibrium states. This type of transition occurs much more rapidly than transitions occurring through horizontal marsh expansion or retreat. In addition, our analyses reveal that river inputs can affect the existence and extent of marsh/tidal flat equilibria by both directly providing suspended sediment (favoring marshes) and by modulating water exchanges with the ocean, thereby indirectly affecting the ocean sediment input to the system (favoring either marshes or tidal flats depending on the ratio of the river and ocean water inputs and their sediment concentrations). The model proposed has the goal of clarifying the roles of the main dynamic processes at play, rather than of predicting the evolution of a particular tidal system. Our model results most directly reflect micro‐ and meso‐tidal environments but also have implications for macro‐tidal settings. The model‐based analyses presented extend our theoretical understanding of marsh dynamics to a greater range of intertidal environments. © 2020 John Wiley & Sons, Ltd.
Chemical composition of cold‐pressed blackberry seed flour extract and its potential health‐beneficial properties
Authors: Choe Uyory , Li Yanfang , Yu Lu , Gao Boyan , Wang Thomas T. Y. , Sun Jianghao , Chen Pei , Yu Liangli 
Published: January 2020

AbstractThe blackberry seed flour was cold‐extracted using 50% acetone and examined for its phytochemical composition and health‐beneficial properties including in vitro gut microbiota modulatory, free radical scavenging, anti‐inflammatory, and antiproliferative capacities. Among identified thirteen components of blackberry seed flour extract through UHPLC‐MS analysis, sanguiin H6 was the primary component and followed by ellagic acid and pedunculagin. For health‐beneficial properties, the blackberry seed flour extract increased the total number of gut bacteria and shifted the abundance of specific bacterial phylum, family, or genus. The extract had RDSC, ORAC, HOSC, and ABTS•+ scavenging capacities of 362, 304, 2,531, and 267 μmol Trolox equivalents (TE)/g, respectively. In addition, the blackberry seed flour extract showed capacities for anti‐inflammation and antiproliferation by suppressing LPS induced IL‐1β mRNA expressions in the cultured J774A.1 mouse macrophages and the proliferation of LNCaP prostate cancer cells. The results suggest potential health benefits and further utilization of blackberry seed flour as functional foods.
Identification and characterization of virulent Aeromonas hydrophila Ah17 from infected Channa striata in river Cauvery and in vitro evaluation of shrimp chitosan
Authors: Samayanpaulraj Vignesh , Sivaramapillai Muthukumar , Palani Sankara Naynar , Govindaraj Krishnaveni , Velu Vijay , Ramesh Uthandakalaipandian 
Published: January 2020

AbstractAeromonas hydrophila, an inhabitant in the aquatic ecosystem is considered as an important foodborne bacterial zoonotic pathogen in aquaculture. The present study aimed to identify virulent A. hydrophila from naturally infected Channa striata in river Cauvery and in vitro evaluation of shrimp chitosan. Rimler Shotts (RS) and blood agar medium identified the presence of pathogenic Aeromonas sp. from the infected C. striata. A. hydrophila Ah17 was identified using 16S rRNA nucleotide sequence. Extracellular enzymes such as amylase, lipase, and protease were screened in A. hydrophila Ah17. Antibiotic susceptibility tests showed A. hydrophila Ah17 was highly resistant against β‐lactam, glycopeptide, macrolides, phosphonic, fucidin, and oxazolidinone classes of antibiotics. Virulent genes such as hemolysin (aer and hly), heat‐labile enterotoxin (act), cytotonic heat‐stable enterotoxin (ast), elastase (ahyB), and lipase (lip) were identified. Growth and the viable cell population of virulent A. hydrophila Ah17 were significantly reduced in a dose‐dependent manner against shrimp chitosan (CHS) from Penaeus indicus (P. indicus). Thus, the present study isolated virulent A. hydrophila Ah17 from the environmental source and characterized in vitro with shrimp chitosan.
A Prognostic Strategy Based on Stage of Cirrhosis and HVPG to Improve Risk Stratification After Variceal Bleeding
Authors: La Mura Vincenzo , Garcia‐Guix Marta , Berzigotti Annalisa , Abraldes Juan G. , García‐Pagán Juan Carlos , Villanueva Candid , Bosch Jaime 
Published: January 2020

Background and Aims
A hepatic venous pressure gradient (HVPG) decrease of 20% or more (or ≤12 mm Hg) indicates a good prognosis during propranolol/nadolol treatment but requires two HVPG measurements. We aimed to simplify the risk stratification after variceal bleeding using clinical data and HVPG.

Methods
A total of 193 patients with cirrhosis (62% with ascites and/or hepatic encephalopathy [HE]) who were within 7 days of bleeding had their HVPG measured before and at 1‐3 months of treatment with propranolol/nadolol plus endoscopic band ligation. The endpoints were rebleeding and rebleeding/transplantation‐free survival for 4 years. Another cohort (n = 231) served as the validation set.

Results
During follow‐up, 45 patients had variceal bleeding and 61 died. The HVPG responders (n = 71) had lower rebleeding risk (10% vs. 34%, P = 0.001) and better survival than the 122 nonresponders (61% vs. 39%, P = 0.001). Patients with HE (n = 120) had lower survival than patients without HE (40% vs. 63%, P = 0.005). Among the patients with ascites/HE, those with baseline HVPG ≤ 16 mm Hg (n = 16) had a low rebleeding risk (13%). In contrast, among patients with ascites/HE and baseline HVPG > 16 mm Hg, only the HVPG responders (n = 32) had a good prognosis, with lower rebleeding risk and better survival than the nonresponders (n = 72) (respective proportions: 7% vs. 39%, P = 0.018; 56% vs. 30% P = 0.010). These findings allowed us to develop a strategy for risk stratification in which HVPG response was measured only in patients with ascites and/or HE and baseline HVPG > 16 mm Hg. This method reduced the “gray zone” (i.e., high‐risk patients who had not died on follow‐up) from 46% to 35% and decreased the HVPG measurements required by 42%. The validation cohort confirmed these results.

Conclusions
Restricting HVPG measurements to patients with ascites/HE and measuring HVPG response only if the patient’s baseline HVPG is over 16 mm Hg improves detection of high‐risk patients while markedly reducing the number of HVPG measurements required.
Fear driven compulsive behaviour is associated with worse long‐term outcome in obsessive–compulsive disorder
Authors: Ferreira Gabriela M. , Albertella Lucy , Moreira‐de‐Oliveira Maria Eduarda , Piquet‐Pessôa Marcelo , Yücel Murat , Lee Rico S.C. , Batista Karina B. , de Menezes Gabriela B. , Fontenelle Leonardo F. 
Published: January 2020

AbstractObjectivesIn this retrospective study of patients with obsessive–compulsive disorder (OCD), we assessed the relationship between different motivational drivers of compulsive behaviours and the response to naturalistic treatments (based mostly on high dose serotonin reuptake inhibitors [SRIs]).MethodsSeventy‐six OCD patients were assessed with a structured diagnostic interview; the Habit, Reward and Fear Scale‐Revised (HRFS‐R); the Yale‐Brown Obsessive–Compulsive Scale (YBOCS); the Beck Depression Inventory (BDI); and the OCD Retrospective Assessment of Treatment Response (RATS), which includes information on SRIs administration (e.g., dose and duration of their use), augmentation strategies (such as antipsychotic use or exposure and response prevention intervention), and pre‐treatment YBOCS scores. Patients were naturalistically followed up for a mean of 7.28 (SD 5.51) years.ResultsAnalysis revealed that the fear subscore of the HRFS was the only significant predictor (among a detailed battery of demographic, clinical and treatment factors) independently associated with greater delta (pre‐treatment minus post‐treatment) YBOCS scores.ConclusionsIn contrast to predictions (based on existing models), poorer treatment response was not associated with increased habit scores in the HRFS. Future longitudinal studies are needed to confirm whether increased fear as a driver for ritualistic behaviours is able to predict worse outcomes in OCD samples.
The necessity‐concern framework in the assessment of treatment adherence of psychiatric patients and the role of polypharmacy in a Spanish sample
Authors: De las Cuevas Carlos , Betancort Moisés , de Leon Jose 
Published: January 2020

AbstractObjectiveThis study compares three measures (necessity and concern scores, the necessity‐concern differential, and a skeptical attitude vs. three other attitudes) for studying the relationship between the necessity‐concern framework and treatment adherence after considering the number of prescribed drugs.MethodsThe sample included 588 consecutive adult psychiatric outpatients in the Canary Islands, Spain. The necessity‐concern framework was assessed using a specific subscale of the Beliefs about Medicines Questionnaire. Adherence (yes/no) to 1,101 prescribed psychiatric drugs was assessed using the Sidorkiewicz adherence tool.ResultsIn the three logistic regression models including 1,101 drugs, with adherence as the dependent variable, the highly significant odds ratios (ORs) and their 95% confidence intervals (CIs) were (a) OR = 1.57 (CI = 1.37–1.79) for necessity and OR = 0.747 (CI = 0.660–0.847) for concern; (b) OR = 1.44 (CI = 1.32–1.58) for the necessity‐concern differential; and (c) OR = 0.452 (CI = 0.343–0.597) for a skeptical attitude (yes/no), defined as low necessity and high concern. In patients taking five or six drugs, adherence was associated with extremely high/low ORs for necessity, concern, and the differential.ConclusionIf replicated, our results suggest clinicians need to pay careful attention to each drug in each patient taking five or six drugs, emphasize necessity, and listen carefully to patient concerns.
ECONOMIC ASSESSMENT OF WATER HARVESTING PLUS SUPPLEMENTAL IRRIGATION FOR IMPROVING WATER PRODUCTIVITY OF A PULSE–COTTON BASED INTEGRATED FARMING SYSTEM IN TELANGANA, INDIA†
Authors: Reddy Konda S. , Ricart Sandra , Maruthi Vegapareddy , Pankaj Prabhat K. , Krishna Tatipamula S. , Reddy A. Amarender 
Published: January 2020

AbstractAn integrated farming system (IFS) aims to sustain agricultural production, maintain farm incomes, safeguard the environment and respond to climate change impacts. Experiments in a tribal farmer's fields during 2016–2018 with two IFS models (pulse and cotton) were conducted in the Telangana region, India. An on‐farm reservoir (OFR) is designed for storing surface runoff based on the area and runoff coefficient determined through a modelling approach. The results demonstrated how supplemental irrigation and water harvesting are the most important and proven technologies for improving crop productivity and the efficient use of water in dryland areas of the semi‐arid tropics. The economic analysis indicated that after introduction of OFR technology, farmers' profits were increased under both scenarios of prolonged and short dry spells. According to the results, adoption of the OFR and IFS models not only ensured economic returns but provided regular employment even on less than 1 ha of land, which is usually non‐sustainable if monocropping is being practised. The approaches used in this work might be useful for guiding producers’ decisions in optimizing resources and selecting crops based on economic and water use efficiency. © 2020 John Wiley & Sons, Ltd.
The effects of combinations of limited ration and diazinon exposure on acetylcholinesterase activity, growth and reproduction in Oryzias latipes, the Japanese medaka
Authors: Flynn Kevin , Johnson Rodney , Lothenbach Doug , Swintek Joe , Whiteman Frank , Etterson Matthew 
Published: January 2020

AbstractEnvironmental contamination can negatively impact fish populations. In addition to acute toxicity leading to death, toxicants can reduce fish growth and lower reproduction. The potential for adverse population level effects of environmental contaminants are estimated to conduct risk assessments from laboratory toxicity tests that most often measure apical endpoints related to growth, survival and reproduction. The relationships between these effect endpoints are being evaluated to predict shifts in fish population demography better after exposure to environmental toxicants. Environmental contaminants can also affect fish populations indirectly by reducing prey biomass. However, estimating the magnitude of the combined effects of prey reduction and direct toxicity is difficult and rarely attempted. Here we describe a toxicity test designed to estimate the effect on Japanese medaka of both reduced food and chronic exposure to diazinon, an acetylcholinesterase inhibiting organophosphate pesticide. Fish were reared with limited food ration and/or diazinon exposure through a full life cycle to assess possible interactions between the two stressors in their effects on growth and reproduction. Diazinon exposure (10 or 20 μg/L), reduced ration (50% and 25% of ad libitum), or combinations of both lowered growth rates and reproductive output of Japanese medaka. In addition, growth and reproduction alone were modeled, and then various relationships between the two stressors (diazinon and ration) and how they relate to growth and reproduction were modeled.
Transgenerational reproductive and developmental toxicity of tebuconazole in Caenorhabditis elegans
Authors: Lu Qian , Bu Yuanqing , Ma Lingyi , Liu Ran 
Published: January 2020

AbstractThe transgenerational reproductive and developmental toxicity of tebuconazole (TEB) in Caenorhabditis elegans was investigated over five generations (P0 − F4). Only parental C.elegans (P0) were exposed to TEB (0, 0.01, 0.1, 1, and 10 μg/L) for 24 h and the subsequent offspring (F1–F4) were grown under TEB‐free conditions. TEB exposure caused dose‐dependent reproductive defects and developmental impairments in C.elegans. In the P0 generation reproductive defects were observed such as: reduced brood size and embryo hatchability, prolonged generation time, retarded gonadal development, and slower germline proliferation, even at 0.01 μg/L, together with developmental toxicity with significant reduced body length and narrowed body width at 10 μg/L. Additionally, the brood size significantly reduced in F2, which began to recover from F3, but was still lower than the control in F4. The proportion of abnormalities increased significantly in F2 and reduced from F3, but was still higher than the control, suggesting that TEB could have cumulative potential and be passed to offspring through parental exposure. Furthermore, exposure to TEB (10 μg/L) in P0 significantly reduced the body length in F1, which began to recover from F2, and was the same level as the control in F4. There was a concentration‐dependent increase in body width in F1–F4, with a significant increase only observed in F1 at 10 μg/L. Thus, parental exposure to TEB induced transgenerational defects in both reproduction and development, emphasizing the significance of considering bio‐toxicity over multiple generations to conduct accurate assessment of environmental risks of toxicants.
An innovative occluder for cardiac defect: 3D printing and a biocompatibility research based on self‐developed bioabsorbable material—LA–GA–TMC
Authors: Sun Yiming , Xia Yinghui , Zhang Xingjian , Li Wenjing , Xing Quansheng 
Published: January 2020

AbstractThis study adopted the latest self‐developed bioabsorbable material lactide–glycolide–1,3‐trimethylene carbonate (LA–GA–TMC) and applied the three‐dimensional (3D) printing technique to manufacture the occluder for cardiac septal defects, so as to realize the individualized treatment of cardiac septal defects. At the same time, its biosafety was evaluated, with an aim to establish foundation for futural large‐scale animal experiment and clinical trial. The traditional “one‐pot synthesis” was modified, and the “two‐step synthesis method” was utilized to synthesize the LA–GA–TMC terpolymer at the lactide: glycolide: trimethylene carbonate ratio of 6:1:1.7. Afterward, the synthesized terpolymer was used as the raw material to fabricate the occluder model via using 3D printing technique. Then, its biocompatibility was comprehensively evaluated through cytocompatibility, blood compatibility, and histocompatibility. The occluder made from LA–GA–TMC 3D printing had favorable ductility and recoverability; besides, it possessed the temperature‐control feature, and the relative cell proliferation rates in extract liquids at various concentrations were all >70%, suggesting that it had favorable cytocompatibility. Moreover, hemolytic experiment revealed that its hemolytic rate was <5%, dynamic blood coagulation experiment demonstrated that the sample material moderately activated the blood coagulation, and the above findings suggested that it had good blood compatibility. In addition, implanting experiment in vivo revealed that its histocompatibility was superior to the traditional nitinol and the emerging poly‐l‐lactic acid. It is completely feasible to manufacture the cardiac septal defects occluder based on the novel absorbable material LA–GA–TMC, which has favorable biocompatibility, through 3D printing technique and it possesses broad prospects in large‐scale animal experiment and clinical trial.
Micro‐CT and histopathology methods to assess host response of aneurysms treated with shape memory polymer foam‐coated coils versus bare metal coil occlusion devices
Authors: Jessen Staci L. , Friedemann Molly C. , Mullen Annmarie E. , Ginn‐Hedman Anne‐Marie , Herting Scott M. , Maitland Duncan J. , Clubb Fred J. 
Published: January 2020

AbstractRecent studies utilizing shape memory polymer foams to coat embolizing coils have shown potential benefits over current aneurysm treatments. In the current study utilizing a rabbit‐elastase aneurysm model, the performance of test article (foam‐coated coil [FCC]) and control (bare platinum coils [BPCs]) devices were compared at 30, 90, and 180 days using micro‐CT and histological assessments. The host response was measured by identifying the cells regionally present within the aneurysm, and assessing the degree of residual debris and connective tissue. The 3D reconstructions of aneurysms provided context for histologic findings, and aided in the overall aneurysm assessment. At all time points, >75% of the cells categorized in each aneurysm were associated with a bioactive yet biocompatible host response (vs. the remainder of cells that were associated with acute inflammation). The extracellular matrix exhibited a transition from residual fibrin at 30 days to a greater degree of connective tissue at 90 and 180 days. Although the control BPC‐treated aneurysms exhibited a greater degree of connective tissue at the earliest time point examined (30 days), by 180 days, the FCC‐treated aneurysms had more connective tissue and less debris overall than the control aneurysms. When considering cell types and extracellular matrix composition, the overall host response scores were significantly better in FCC‐treated aneurysms at the later time point. Based on the results of these metrics, the FCC device may lead to an advanced tissue remodeling response over BPC occlusion devices.