bluuebunny/crossref_metadata_2025_split huggingface dataset:
The genome of Shanputao (Vitis amurensis) provides a new insight into cold tolerance of grapevine
Authors: Wang Yi , Xin Haiping , Fan Peige , Zhang Jisen , Liu Yongbo , Dong Yang , Wang Zemin , Yang Yingzhen , Zhang Qing , Ming Ray , Zhong Gan‐Yuan , Li Shaohua , Liang Zhenchang 
Published: December 2020

SUMMARYVitis amurensis (Shanputao) is the most cold tolerant Vitis species and so is of great interest to grape breeders and producers in areas with low winter temperatures. Here, we report its high‐quality, chromosome‐level genome assembly based on a combination of sequence data from Illumina and PacBio platforms, BioNano optical mapping and high‐throughput chromosome conformation Capture (Hi‐C) mapping. The 604.56‐Mb genome contains 32 885 protein‐coding genes. Shanputao was found to share a common ancestor with PN40024 (V. vinifera) approximately 2.17–2.91 million years ago, and gene expansion observed in Shanputao might contribute to the enhancement of cold tolerance. Transcriptome analysis revealed 17 genes involved in cold signal transduction, suggesting that there was a different response mechanism to chilling temperature and freezing conditions. Furthermore, a genome‐wide association study uncovered a phosphoglycerate kinase gene that may contribute to the freezing resistance of buds in the winter. The Shanputao genome sequence not only represents a valuable resource for grape breeders, but also is important for clarifying the molecular mechanisms involved in cold tolerance.
The somatosensory cortical activity in individuals with cerebral palsy displays an aberrant developmental trajectory
Authors: Trevarrow Michael P. , Kleinsmith Joseph , Taylor Brittany K. , Wilson Tony W. , Kurz Max J. 
Published: December 2020

Key points
Individuals with cerebral palsy (CP) have a reduced somatosensory cortical response
Somatosensory cortical response strength decreases from adolescence to early adulthood
Somatosensory cortical responses in youth with CP are similar to adult controls
Individuals with CP may have aberrant maturation of the somatosensory system
AbstractNumerous studies have documented tactile and proprioceptive deficits in children with cerebral palsy (CP) and linked these with weaker somatosensory cortical activity. However, whether such aberrations in somatosensory processing extend and/or progress into adulthood remains poorly understood. In the current study, we used magnetoencephalography (MEG) to investigate the primary somatosensory responses in a sample of individuals with CP (N = 42; age = 9–28 years) and a cohort of healthy controls (N = 23; age range = 11–23 years). Briefly, transient electrical stimulation was applied to the right tibial nerve, and standardized low‐resolution brain electromagnetic tomography (sLORETA) was used to image the dynamic somatosensory cortical response. We found that the strength of somatosensory cortical activity within the 112–252 ms time window was significantly reduced in the individuals with CP compared with the healthy controls (HC = 286.53 ± 30.51, 95% CI [226.74, 346.32]; CP = 208.30 ± 19.66,CI [169.77, 246.83], P = 0.0126). These results corroborate previous findings of aberrant somatosensory cortical activity in individuals with CP. Our results also suggest that the somatosensory cortical activity tends to become weaker with age, with a similar rate of neurophysiological change in individuals with CP and healthy controls (P = 0.8790). Visualization of regression models fitted to the data imply that youth with CP may have somatosensory cortical activity similar to adult controls. These findings suggest that some individuals with CP exhibit an aberrant developmental trajectory of their somatosensory system.
Taking the Measure of Electric Vehicles
Authors: Michaelides Efstathios E. 
Published: December 2020

Abstract
An engineer with more than 45 years’ experience on efficiency claims takes a look at whether electric vehicles are much more efficient than conventional cars powered by internal combustion engines. He found that EVs are marginally more efficient than the technology they are positioned to replace. A lot of the potential for improvement is, however, contingent on where the electricity comes from and how the vehicles are charged.
Tectonic and magmatic evolution of the Aqishan-Yamansu belt: A Paleozoic arc-related basin in the Eastern Tianshan (NW China)
Authors: Zhang Shuanliang , Chen Huayong , Hollings Pete , Zhao Liandang , Gong Lin 
Published: December 2020

Abstract
The Aqishan-Yamansu belt in the Chinese Eastern Tianshan represents a Paleozoic arc-related basin generally accompanied by accretionary magmatism and Fe-Cu mineralization. To characterize the tectonic evolution of such an arc-related basin and related magmatism and metallogenesis, we present a systematic study of the geochronology, whole-rock geochemistry, and Sr-Nd isotopes of igneous rocks from the belt. New zircon U-Pb ages, in combination with published data, reveal three phases of igneous activity in the Aqishan-Yamansu belt: early Carboniferous felsic igneous rocks (ca. 350–330 Ma), late Carboniferous intermediate to felsic igneous rocks (ca. 320–305 Ma), and Permian quartz diorite and diorite porphyry dikes (ca. 280–265 Ma). The early Carboniferous felsic rocks are enriched in large ion lithophile elements (LILEs) and depleted in Nb, Ta, and Ti, showing arc-related magma affinities. Their positive εNd(t) values (3.3–5.9) and corresponding depleted mantle model ages (TDM) of 0.83–0.61 Ga, as well as high MgO contents, Mg# values, and Nb/Ta ratios, suggest that they were derived from lower crust with involvement of mantle-derived magmas. The late Carboniferous intermediate igneous rocks show calc-alkaline affinities, exhibiting LILE enrichment and high field strength element (HFSE) depletion, with negative Nb and Ta anomalies. They have high MgO contents and Mg# values with positive εNd(t) values (3.9–7.9), and high Ba/La and Th/Yb ratios, implying a depleted mantle source metasomatized by slab-derived fluids and sediment or sediment-derived melts. The late Carboniferous felsic igneous rocks are metaluminous to peraluminous with characteristics of medium-K calc-alkaline I-type granites. Given the positive εNd(t) values (6.3–6.6) and TDM ages (0.56–0.53 Ga), we suggest the late Carboniferous felsic igneous rocks were produced by partial melting of a juvenile lower crust. The Permian dikes show characteristics of adakite rocks. They have relatively high MgO contents and Mg# values, and positive εNd(t) values (7.2–8.5), which suggest an origin from partial melting of a residual basaltic oceanic crust. We propose that the Aqishan-Yamansu belt was an extensional arc–related basin from ca. 350 to 330 Ma; this was followed by a relatively stable carbonate formation stage at ca. 330–320 Ma, when the Kangguer oceanic slab subducted beneath the Central Tianshan block. As the subduction continued, the Aqishan-Yamansu basin closed due to slab breakoff and rebound during ca. 320–305 Ma, which resulted in basin inversion and the emplacement of granitoids with contemporary Fe-Cu mineralization. During the Permian, the Aqishan-Yamansu belt was in postcollision extension stage, with Permian adakitic dikes formed by partial melting of a residual oceanic crust.
Efficiency of eclogite removal from continental lithosphere and its implications for cratonic diamonds
Authors: Luo Yantao , Korenaga Jun 
Published: December 2020

AbstractContinental lithospheric mantle (CLM) may have been built from subducted slabs, but the apparent lack of concurrent oceanic crust in CLM, known as the mass imbalance problem, remains unresolved. Here, we present a simple dynamic model to evaluate the likelihood of losing dense eclogitized oceanic crust from CLM by gravitational instability. Our model allowed us to assess the long-term evolution of such crust removal, based on how thermal and viscosity profiles change over time across the continental lithosphere. We found that the oceanic crust incorporated early into CLM can quickly escape to the asthenosphere, whereas that incorporated after a certain age would be preserved in CLM. This study provides a plausible explanation for the mass imbalance problem posed by the oceanic ridge origin hypothesis of CLM and points to the significance of preservation bias inherent to the studies of cratonic diamonds.
Paediatric major incident simulation and the number of discharges achieved using a major incident rapid discharge protocol in a major trauma centre: a retrospective study
Authors: Bird Ruth , Braunold Daniel , Dryburgh-Jones Jack , Davis Jordan , Rogers Sam , Sohrabi Catrin , Ismail Elliot , Mclean Nina , O’neill Breda , Edmonds Naomi , Tallach Rosel 
Published: December 2020

ObjectivesHospitals have the responsibility of creating, testing and maintaining major incident (MI) plans. Plans emphasise readiness for acceptance of casualties, though often they neglect discharge planning and care for existing inpatients to make room for the sudden influx.After collaboration and design of a discharge policy for a paediatric MI, we aimed to establish the number of beds made available (primary outcome) to assess potential surge and patient flow. We hypothesised that prompt patient discharge would improve overall departmental flow. Flow is vital for sick patients awaiting admission, for those requiring theatre and also to keep the emergency department clear for ongoing admissions.Method and settingA simulated MI was declared at a London major trauma centre. Five paediatric priority 1 and 15 priority 2 and priority 3 patients were admitted. Using live bed boards, staff initiated discharge plans, and audits were conducted based on hospital bed occupancy and discharge capacity. The patients identified as dischargable were identified and folllowed up for 7 days.ResultsTwenty-nine ward beds were created (42% of the total capacity). Handwritten summaries just took 13.3% of the time that electronic summaries took for the same patients by the same doctor. In-hospital transfers allowed five critically injured children into paediatric intensive care unit (PICU), and creation of a satellite PICU allowed for an additional six more if needed.ConclusionWe increased level 3 capacity threefold and created 40% extra capacity for ward patients. A formalised plan helped with speed and efficiency of safe discharge during an MI. Carbon copy handwritten discharge letters allowed tracking and saved time. Robust follow-up procedures must be in place for any patients discharged.
Patient and provider perspectives on barriers to screening for diabetic retinopathy: an exploratory study from southern India
Authors: Kumar Shuba , Kumar Geetha , Velu Saranya , Pardhan Shahina , Sivaprasad Sobha , Ruamviboonsuk Paisan , Raman Rajiv 
Published: December 2020

ObjectiveDiabetic retinopathy is one of the leading causes of visual impairment after cataract and uncorrected refractive error. It has major public health implications globally, especially in countries such as India where the prevalence of diabetes is high. With timely screening and intervention, the disease progression to blindness can be prevented, but several barriers exist. As compliance to diabetic retinopathy screening in people with diabetes is very poor in India, this study was conducted to explore understanding of and barriers to diabetic retinopathy screening from the perspectives of patients and healthcare providers.MethodsUsing qualitative methods, 15 consenting adult patients with diabetes were selected purposively from those attending a large tertiary care private eye hospital in southern India. Eight semistructured interviews were carried out with healthcare providers working in large private hospitals. All interviews were audiotaped, transcribed verbatim and analysed using the framework analytical approach.ResultsFour themes that best explained the data were recognising and living with diabetes, care-seeking practices, awareness about diabetic retinopathy and barriers to diabetic retinopathy screening. Findings showed that patients were aware of diabetes but understanding of diabetic retinopathy and its complications was poor. Absence of symptoms, difficulties in doctor–patient interactions and tedious nature of follow-up care were some major deterrents to care seeking reported by patients. Difficulties in communicating information about diabetic retinopathy to less literate patients, heavy work pressure and silent progression of the disease were major barriers to patients coming for follow-up care as reported by healthcare providers.ConclusionsEnhancing patient understanding through friendly doctor–patient interactions will promote trust in the doctor. The use of an integrated treatment approach including education by counsellors, setting up of patient support groups, telescreening approaches and use of conversation maps may prove more effective in the long run.
Tuina for spasticity of poststroke: protocol of a systematic review and meta-analysis
Authors: Zhang Qiongshuai , Ji Guangcheng , Cao Fang , Sun Yihan , Hu Guanyu , Sun Shaoqian , Liu Yanze , Cao Jiazhen , Wang Yufeng , Xu Xiaohong , Song Bailin 
Published: December 2020

IntroductionSpasticity is a common complication of poststroke, tuina is a widely used rehabilitation treatment, although there is a lack of supportive evidence on efficacy and safety for patients with poststroke spasticity. The aim of this systematic review is to assess and synthesis evidence of efficacy and safety of tuina for spasticity of poststroke.Methods and analysisA comprehensive electronic search of EMBASE, MEDLINE, Cochrane Library, Web of Science, Wiley, Springer, PEDro, Chinese Science Citation Database, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, Chinese Scientific and Journal Database (VIP), Wanfang Database (Wanfang), Japanese medical database (CiNii), Korean Robotics Institute Summer Scholars and Thailand Thai-Journal Citation Index Centre will be conducted to search literatures of randomised controlled trials of tuina for spasticity of poststroke survivors range from the establishment to 1 January 2020.There is no time of publication limitations. The primary outcome will be measured with the Modified Ashworth Scale, and the second outcome will include Fugl-Meyer Assessment Scale, surface electromyogram RMS value, the Modified Barthel Index, Stroke Specific Quality of Life Scale, quality of life 36-Item Short-Form Health Survey and Visual Analogue Scale. Cochrane Handbook for Systematic Reviews of Interventions will be used to assess the risk of bias, and GRADE will be used to access the confidence in cumulative evidence. The protocol will be conducted according to approach and Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols 2015.Ethics and disseminationEthical approval will not be required, for no primary data of individual patients were collected. We will publish the findings in a peer-reviewed journal.PROSPERO registration numberCRD42020163384.
Effectiveness of a web-based decision aid for patients with generalised anxiety disorder: a protocol for a randomised controlled trial
Authors: Perestelo-Pérez Lilisbeth , Rivero-Santana Amado , Ramos-García Vanesa , Álvarez-Pérez Yolanda , Duarte-Díaz Andrea , Torres-Castaño Alezandra , Trujillo-Martín Maria del Mar , Del Pino-Sedeño Tasmania , González-González Ana Isabel , Serrano-Aguilar Pedro 
Published: December 2020

IntroductionPatients with generalised anxiety disorder (GAD) have concerns and needs about their health and the healthcare they receive. Patient decision aids (PtDAs) are tools that assist patients in making health decisions, when there is uncertainty about treatment choice, incorporating their personal preferences and values about the available treatment options. PtDAs can improve shared decision-making and lead to better treatment outcomes. The aim of this study is to evaluate the effectiveness of a web-based PtDA for patients with GAD in primary care (PC).Methods and analysisThe general study design is comprised of two stages: (1) development of a web-based PtDA for patients with GAD, derived from an evidence-based Clinical Practice Guideline and (2) assessment of the effectiveness of the PtDA in a randomised controlled trial (RCT) design, in PC centres in Tenerife (Spain). This RCT will be carried out with 124 patients with GAD, comparing the PtDA to a fact sheet with general information on mental health. Patients will review the PtDA in one session accompanied by a researcher. Post-intervention measures will be administered immediately after the intervention and at 3-month follow-up. The primary outcome will be decisional conflict. Secondary outcomes will include knowledge about GAD and its treatment, treatment preference, concordance between treatment preference and choice, and decision quality (knowledge ≥60% and concordant decision).Ethics and disseminationThe project received ethics approval from the local committee at Nuestra Señora de la Candelaria (HUNSC) University Hospital in Santa Cruz de Tenerife (code: CHUNSC_2019_58). Informed consent will be obtained from each participant before randomisation. Results from the trial will be submitted for publication in international peer-reviewed scientific journals and will be disseminated through workshops and local and international conferences.Trial registration numberNCT04364958.
Modified minimally invasive surgical technique plus Bio-Oss Collagen for regenerative therapy of isolated interdental intrabony defects: study protocol for a randomised controlled trial
Authors: Zhang Churen , Zhang Haidong , Yue Zhaoguo , Miao Lili , Han Ye , Liu Kaining , Hou Jianxia 
Published: December 2020

IntroductionPeriodontal regeneration surgery has been widely used to deal with intrabony defects. Modified minimally invasive surgical technique (M-MIST) is designed to deal with isolated interdental intrabony defects, and has achieved satisfactory periodontal regenerative effect. Bio-Oss Collagen, as a bioactive material, has been applied for periodontal regeneration. It is similar to human cancellous bone, with the ability to promote bone formation; furthermore, it has exceptional plasticity and spatial stability. The combination of different materials and techniques has become a research hotspot in recent years. By combining the superiority of regeneration technology and materials, better regenerative effect can be achieved. This study will search for differences between M-MIST combined with Bio-Oss Collagen, and M-MIST alone in regeneration therapy for intrabony defects.Methods and analysisThe present research is designed as a two-group parallel randomised controlled trial. The total number of patients is 40. The patients will be randomly assigned to two groups, with 20 participants in each group, for further periodontal regenerative surgery. Test group: M-MIST plus Bio-Oss Collagen. Control group: M-MIST. After 12 months, the measurement indices will be recorded; these will include clinical attachment gain and radiographical intrabony defect depth change as the primary results, and secondary outcomes of full-mouth plaque scores, probing depth, full-mouth bleeding scores, gingival recession, mobility, gingival papilla height and Visual Analogue Scale. The paired samples t-test will be applied to detect any difference between baseline and 1-year registrations. A general linear model will be performed to study the relationship between the secondary and the primary outcome.Ethics and disseminationThe present research has received approval from the Ethics Committee of Peking University School and Hospital of Stomatology (PKUSSIRB-202053002). Data of the present research will be registered with the International Clinical Trials Registry Platform. Additionally, we will disseminate the results through scientific dental journals.Trial registration numberChiCTR-2000030851.Protocol versionProtocol Version 4, 14 July 2020.
Impact of arthritis on the perceived need and use of mental healthcare among Canadians with mental disorders: nationally representative cross-sectional study
Authors: Howren Alyssa , Aviña-Zubieta J Antonio , Da Costa Deborah , Puyat Joseph H , Xie Hui , De Vera Mary A 
Published: December 2020

ObjectiveTo evaluate the association between having arthritis and the perceived need for mental healthcare and use of mental health support among individuals with mental disorders.DesignA cross-sectional analysis using data from Canadian Community Health Survey—Mental Health (2012).SettingThe survey was administered across Canada’s 10 provinces using multistage cluster sampling.ParticipantsThe study sample consisted of individuals reporting depression, anxiety or bipolar disorder.Study variables and analysisThe explanatory variable was self-reported doctor-diagnosed arthritis, and outcomes were perceived need for mental healthcare and use of mental health support. We computed overall and gender-stratified multivariable binomial logistic regression models adjusted for age, gender, race/ethnicity, income and geographical region.ResultsAmong 1774 individuals with a mental disorder in the study sample, 436 (20.4%) reported having arthritis. Arthritis was associated with increased odds of having a perceived need for mental healthcare (adjusted OR (aOR) 1.71, 95% CI 1.06 to 2.77). In the gender-stratified models, this association was increased among men (aOR 2.69, 95% CI 1.32 to 5.49) but not women (aOR 1.48, 95% CI 0.78 to 2.82). Evaluation of the association between arthritis and use of mental health support resulted in an aOR of 1.50 (95% CI 0.89 to 2.51). Individuals with arthritis tended to use medications and professional services as opposed to non-professional support.ConclusionComorbid arthritis among individuals with a mental disorder was associated with an increased perceived need for mental healthcare, especially in men, underscoring the importance of understanding the role of masculinity in health seeking. Assessing the mental health of patients with arthritis continues to be essential for clinical care.
Does disability modify the relationship between labour force status and psychological distress among young people?
Authors: Shields Marissa , Dimov Stefanie , King Tania L , Milner Allison , Kavanagh Anne , Spittal Matthew J , Disney George 
Published: December 2020

ObjectiveTo examine the association between labour force status, including young people who were unemployed and having problems looking for work, and psychological distress one year later. We then assessed whether this association is modified by disability status.MethodsWe used three waves of cohort data from the Longitudinal Surveys of Australian Youth. We fitted logistic regression models to account for confounders of the relationship between labour force status (employed, not in the labour force, unemployed and having problems looking for work) at age 21 years and psychological distress at age 22 years. We then estimated whether this association was modified by disability status at age 21 years.ResultsBeing unemployed and having problems looking for work at age 21 years was associated with odds of psychological distress that were 2.48 (95% CI 1.95 to 3.14) times higher than employment. There was little evidence for additive effect measure modification of this association by disability status (2.52, 95% CI −1.21 to 6.25).ConclusionsYoung people who were unemployed and having problems looking for work had increased odds of poor mental health. Interventions should focus on addressing the difficulties young people report when looking for work, with a particular focus on supporting those young people facing additional barriers to employment such as young people with disabilities.