bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biological and ecological classification of biomimicry from a biology push standpoint
Authors: Bae Haejin , Lee Eunok 
Published: November 2019

AbstractBiomimicry refers to a cooperative process that develops a sustainable world by taking inspiration from the structure, function, process, and mechanism of an organism adapted to the environment through the evolution of nature. A classification system of biomimicry from a biological and ecological point of view (biology push) can provide a framework for the sustainable development of society, the environment, and the economy. Thus, the purpose of this study was to categorize biological and ecological functions and to present a collaborative biomimicry system that suggests engineering and industrial sectors where biomimicry functions can be applied. Based on biology push, the biological and ecological functions were divided into six groups with subgroups of specific features, related to the fields of technology and industry. Through the formulation of the new biological functional framework, the biomimicry system can be used as a simple classification tool to determine the expected value of the final product as well as provide the knowledge data required in engineering and industry.
CCR9 signaling in dendritic cells drives the differentiation of Foxp3+ Tregs and suppresses the allergic IgE response in the gut
Authors: Pathak Manisha , Padghan Priyanka , Halder Namrita , Shilpi  , Kulkarni Neeraja , Sonar Sandip A. , Lal Girdhari 
Published: November 2019

AbstractThe chemokine receptor CCR9 and its only known ligand CCL25 play an important role in gut inflammation and autoimmune colitis. The function of CCR9‐CCL25 in the migration of immune cells is well characterized. However, its role in the immune cell differentiation is mostly not known. Using dextran sodium sulfate (DSS)‐induced gut inflammation model, we showed that CCR9+ dendritic cells (DCs) specifically CD11b−CD103+ DCs were significantly increased in the gut‐associated lymphoid tissues (GALT) compared to control mice. These CCR9+ DCs express lower MHC II and CD86 molecules and had regulatory surface markers (FasL and latency‐associated peptide, LAP) in the GALT. In the presence of CCL25, CCR9+ DCs promoted in vitro differentiation of Foxp3+ regulatory CD4+ T cells (Tregs). CCL25‐induced differentiation of Tregs was due to intrinsic signaling in the DCs but not through CD4+ T cells, which was driven by the production of thymic stromal lymphopoietin (TSLP) and not IL‐10. Furthermore, adoptive transfer of CCR9+ DCs in C57BL/6 mice promoted Tregs but reduced the Th17 cells in the GALT, and also suppressed the OVA‐specific gut‐allergic response. Our results suggest CCR9+ DCs have a regulatory function and may provide a new cellular therapeutic strategy to control gut inflammation and allergic immune reaction.
Using model error in response history analysis to evaluate component calibration methods
Authors: Zsarnóczay Adam , Baker Jack W. 
Published: November 2019

SummaryThis research is part of a larger effort to better understand and quantify the epistemic model uncertainty in dynamic response‐history simulations. This paper focuses on how calibration methods influence model uncertainty. Structural models in earthquake engineering are typically built up from independently calibrated component models. During component calibration, engineers often use experimental component response under quasi‐static loading to find parameters that minimize the error in structural response under dynamic loading. Since the calibration and the simulation environments are different, if a calibration method wants to provide optimal parameters for simulation, it has to focus on features of the component response that are important from the perspective of global structural behavior. Relevance describes how efficiently a calibration method can focus on such important features. A framework of virtual experiments and a methodology is proposed to evaluate the influence of calibration relevance on model error in simulations. The evaluation is demonstrated through a case study with buckling‐restrained braced frames (BRBF). Two calibration methods are compared in the case study. The first, highly relevant calibration method is based on stiffness and hardening characteristics of braces; the second, less relevant calibration method is based on the axial force response of braces. The highly relevant calibration method consistently identified the preferable parameter sets. In contrast, the less relevant calibration method showed poor to mediocre performance. The framework and methodology presented here are not limited to BRBF. They have the potential to facilitate and systematize the improvement of component‐model calibration methods for any structural system.
LCPPA: Lattice‐based conditional privacy preserving authentication in vehicular communication
Authors: Dharminder Dharminder , Mishra Dheerendra 
Published: November 2019

AbstractVehicular ad hoc network (VANET) plays an extremely important role in intelligent transportation systems. It enables vehicles equipped with smart devices to communicate with vehicles or available road side units or infrastructure. It has been observed that the security of data and privacy of user are two key challenges for vehicular communication to enable sharing of resources among unfamiliar vehicles. The existing classical cryptography‐based schemes are not secure in the quantum computing world due to Shor's algorithm. To address the challenges in post‐quantum era, we have presented a framework based on short integer solution problem in some lattice that attains all effective identification and authenticity of the user to get authorized access, along with revocation to services. The integrity of proposed framework ensures that information is accurate and can be trusted. This paper ensures conditional autonomous driving and efficient vehicular traffic flow in a VANET. As a result, the presented protocol is suitable for practical applications even in the post‐quantum environment, which can be utilized for reliable vehicular communication.
Ewing sarcoma with FEV gene rearrangements is a rare subset with predilection for extraskeletal locations and aggressive behavior
Authors: Tsuda Yusuke , Dickson Brendan C. , Swanson David , Sung Yun‐Shao , Zhang Lei , Meyers Paul , Healey John H. , Antonescu Cristina R. 
Published: November 2019

AbstractThe molecular hallmark of Ewing sarcoma (ES) is a fusion involving the EWSR1 gene and a member of the ETS family of transcription factors. EWSR1‐FLI1 is the most common variant, occurring in 90% of cases, followed by EWSR1‐ERG. In a small subset, the FUS gene can substitute for EWSR1 in these fusions. Only rare case reports have been described to date of ES with FEV gene rearrangements. In this study, we investigate the clinicopathologic and molecular features of 10 ES patients with FEV‐rearrangements, either fused to EWSR1 (n = 4) or to FUS (n = 6). The median age at diagnosis was 38 years (range, 5‐61 years); occurring in six males and four females. All tumors were located at extraskeletal sites, occurring more often in the axial soft tissues. Tumors had a similar morphologic appearance and immunophenotype as ES with more common EWSR1‐ETS fusions. Of six patients with follow‐up data, five patients (83%) developed metastasis and two patients (33%) died of their diseases. The diagnosis was confirmed either by fluorescence in situ hybridization and/or targeted RNA sequencing. In the five cases tested by targeted sequencing, the fusion transcripts were composed of EWSR1 or FUS fused to either exon 1 or 2 of FEV, retaining the FEV ETS DNA binding domain. This is the largest study to date investigating the ES subset with EWSR1/FUS‐FEV fusions showing a predilection for extraskeletal sites and aggressive behavior.
Perceived threat of Alzheimer's disease and related dementias in Chinese older adults: The role of knowledge and perceived stigma
Authors: Gao Ms Xiang , Gao Mr Xiang , Guo Lin , Sun Fei , Zhang Anao 
Published: November 2019

ObjectivesThis study focused on perceived threat of Alzheimer's disease and related dementias (ADRD) in Chinese older adults and investigated its associations with their perceived stigma and knowledge of ADRD.MethodsWe examined Chinese older adults' perceived threat of ADRD and its associations with perceived stigma, knowledge of ADRD, family variables and health variables. Data for this cross‐sectional study were collected by student interviewers in 2016. The participants (N = 754) were recruited from two urban communities in mainland China and their ages ranged from 60 to 89 (M = 69.54, SD = 7.35).ResultsHierarchical regression analyses indicated that those who are younger, have more depressive symptoms and lower levels of family cohesion are more likely to worry about ADRD. More ADRD knowledge and higher levels of perceived stigma are significantly associated with perceived threat of ADRD. Community site moderated the relationship between stigma and perceived threat of ADRD.ConclusionsIntervention or service programs need to promote ADRD knowledge and awareness in a culturally sensitive way as well as address stigma and fear toward ADRD in the older population. Future studies are needed to incorporate more cultural and environmental factors to fully understand Chinese older adults' attitudes toward and literacy of ADRD.
Perceived social isolation and cognitive functioning. Longitudinal findings based on the German Ageing Survey
Authors: Hajek André , Riedel‐Heller Steffi G. , König Hans‐Helmut 
Published: November 2019

ObjectivesThere is a lack of longitudinal studies, which are both based on nationally representative samples and use standardized instruments to quantify social isolation. Thus, the purpose of this study was to determine the link between perceived social isolation and cognitive functioning longitudinally.Methods/DesignLongitudinal data with n = 6420 from 2014 (wave 5) to 2017 (wave 6) were drawn from the German Ageing Survey (nationally representative sample of individuals aged 40 years and over). Perceived social isolation was assessed using a scale by Bude and Lantermann. Cognitive functioning was quantified using the established digit symbol test. To reduce the problem of unobserved heterogeneity, linear fixed effects regressions were used.ResultsRegressions showed that increases in perceived social isolation were associated with decreases in cognitive functioning. With regard to covariates, decreases in cognitive functioning were associated with increases in aging and worsening self‐rated health, whereas changes in marital status, employment status, income, physical functioning, and physical illnesses were not associated with the outcome measure.ConclusionsBased on a nationally representative sample and exploiting the panel data structure, the study findings extend current knowledge by showing that increasing perceived social isolation contributes to decreases in cognitive functioning among individuals aged 40 years and over longitudinally. Future longitudinal studies based on panel data methods are required to validate the study findings.
Safety and efficacy of contained manual morcellation during laparoscopic or robotic gynecological surgery
Authors: Hong Mun Kun , Wei Yu‐Chi , Chu Tang‐Yuan , Wang Jen‐Hung , Ding Dah‐Ching 
Published: November 2019

AbstractObjectiveTo assess the safety and efficacy of contained manual morcellation (CMM) with a tissue pouch during minimally invasive robotic or laparoscopic surgeries.MethodsA retrospective cohort study included women who underwent robotic or laparoendoscopic single‐site surgery at a tertiary referral center between February 2014 and April 2017. The specimen was postoperatively contained, sliced into one or more long strips, and then pulled out. The surgical type, specimen containment time, containment failure rate, specimen weight, manual morcellation time, and overall CMM speed (g/min) were recorded. Surgical complications related (bowel or bladder injury, ureteral injury, vascular injuries, and tumor dissemination) or not related (delayed wound healing, infection, and hernia) to CMM were also documented. The patients were followed up for 2 years.ResultsA total of 165 cases were recorded, comprising 149 cases that underwent laparoscopic and 16 that underwent robotic gynecological surgeries. The average time for specimen containment and manual morcellation in CMM was 6.7 ± 5.0 and 13.2 ± 11.2 min, respectively. The mean morcellation speed was 25.1 ± 8.5 g/min. Among the specimens, those of the uterus with adenomyosis had the lowest CMM speed (21.4 ± 8.0 g/min), whereas those of the uterus with myoma had the highest speed (27.5 ± 8.9 g/min). The pouch perforation rate after CMM was 13.3% and no pouch‐related complication was noted.ConclusionCMM is an efficient method for specimen removal.
Single‐use IgE‐selective immunoadsorber column for the treatment of severe atopic dermatitis
Authors: Meyersburg Damian , Laimer Martin , Kugler Andrea , Mühlthaler Eva , Lindlbauer Nadja , Hitzl Wolfgang , Rohde Eva , Bauer Johann W. , Grabmer Christoph 
Published: November 2019

AbstractBackgroundAtopic dermatitis (AD) is a chronic and relapsing inflammatory skin disease with unmet therapeutic need in a critical cohort of recalcitrant cases. Immunoadsorption (IA) aims at an immunomodulatory depletion of pathogenic serum mediators and has recently revealed promising clinical results for the treatment of AD.ObjectiveTo determine efficacy, sustainability, safety, and clinical impact of IgE selective IA in AD using a single‐use IgE immunoadsorber column.MethodsThis open‐label pilot study comprised five patients (mean SCORAD 67.9 ± 11.4, range 52.2‐81.9; mean serum IgE level 5904 ± 5945 U/mL, range 1000‐15 600 IU/mL) who underwent IgE‐selective IA. Three patients continued prior therapy with systemic immunosuppressive drugs during IA as an add‐on therapeutic approach. All patients received three courses of IA. The first course consisted of three consecutive daily treatments followed by two sequences with two consecutive applications. All courses were performed on a monthly regimen.ResultsIA proved efficacy in selectively depleting serum IgE levels in all participants (mean reduction by cycle of 81% ± 12%, range 64%‐93%). It further led to a clinically relevant and sustained improvement of AD with a maximum decline in SCORAD and EASI scores by up to 35% and 52%, respectively, compared to baseline. Scores persisted below baseline for at least 12 weeks beyond the last IA. The intervention was also well tolerated with no severe adverse events during a total of 35 procedures.ConclusionData of this preliminary trial indicates clinical efficacy, feasibility, safety as well as tolerability of IgE‐selective IA in AD.
Differences in oncological outcomes and inflammatory biomarkers between right‐sided and left‐sided stage I‐III colorectal adenocarcinoma
Authors: Guo Dongming , Li Xinxin , Xie Aosi , Cao Qiangjian , Zhang Jinhai , Zhang Feiran , Li Wei , Chen Juntian 
Published: November 2019

AbstractBackgroundThe aim of this study was to investigate the differences in oncological outcome and inflammatory biomarkers between right‐sided colon cancer (RCC) and left‐sided colorectal cancer (LCRC).MethodsWe retrospectively analyzed 339 patients with stage I‐III colorectal cancer, including 125 RCC patients and 214 LCRC patients, who underwent radical resection from January 2012 to January 2014. Comparison of neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR), and lymphocyte‐to‐monocyte ratio (LMR) between RCC and LCRC was evaluated using the Mann‐Whitney U test. Overall survival (OS) and disease‐free survival (DFS) were analyzed using Kaplan‐Meier analysis and compared using the log‐rank test. Univariate and multivariate Cox regression analyses were used to identify the prognostic value of inflammatory markers.ResultsPatients with RCC had higher NLR (P = .002) and PLR (P < .001) but lower LMR (P = .002) compared to LCRC. In stage I‐III, RCC showed poorer OS and DFS than LCRC (61.6% vs 71.5%, P = .018; 64.8% vs 76.2%, P = .006). Univariate and multivariate analyses indicated that NLR, PLR, and LMR were independent predictors for both OS and DFS in RCC, whereas only PLR was found to be an independent prognostic predictor in LCRC.ConclusionThe prognosis and prognostic value of inflammatory biomarkers were significantly different between RCC and LCRC. Novel therapeutic strategies are needed, and proper prognostic predictors should be selected according to colorectal tumor location.
A simplified composite outcome measure to assess the effect of periodontal regenerative treatment in intraosseous defects
Authors: Trombelli Leonardo , Farina Roberto , Vecchiatini Renata , Maietti Elisa , Simonelli Anna 
Published: November 2019

AbstractBackgroundTo propose a novel composite outcome measure (COM) for periodontal regenerative treatment of intraosseous defects.MethodsCOM is based on the combination of clinically relevant clinical attachment level (CAL) gain (≥3 mm) and pocket closure (post‐surgery probing depth [PD] ≤ 4 mm). Treatment was regarded as successful when a clinically relevant CAL gain was associated with pocket closure, and failing when either clinically relevant CAL gain and pocket closure were not achieved. The effect of the different regenerative treatments was both collectively and separately evaluated according to COM in a defect cohort accessed by Single Flap Approach (SFA).ResultsIn the entire study cohort, the procedure resulted in a 6‐month CAL gain of 3.7 ± 1.9 mm, which was clinically relevant in 71.8% of patients. Six‐month residual PD was 3.7 ± 1.1 mm, with pocket closure recorded in 79.6% of patients. COM revealed a successful treatment in 60 patients (58%), and a treatment failure in 7 patients (7%). Mean CAL gain was clinically relevant for each treatment, whereas the residual PD values were consistent with pocket closure for the majority of treatment options. However, when COM was used to rate the treatment outcome of each procedure, it appeared that a successful treatment ranged from 41.5% to 77.5%, whereas treatment failure varied from 3% to 15% for different treatments.ConclusionsCompared to single probing measurements, COM seems (1) more accurate in capturing the overall benefit of the regenerative procedure and (2) to better identify which factor (CAL gain, residual pocket) mainly contributed to determine a treatment failure.
Evaluation of bacterial and fungal communities during the fermentation of Baixi sufu, a traditional spicy fermented bean curd
Authors: Wan Hongfang , Liu Ting , Su Caiwei , Ji Xu , Wang Liping , Zhao Yong , Wang Zhengquan 
Published: November 2019

AbstractBACKGROUNDBaixi sufu (BS) is a traditional Chinese spicy fermented bean curd manufactured with a natural starter. In this study, the bacterial and fungal communities during BS fermentation were determined by culture and by the culture‐independent method of high‐throughput sequencing (HTS). Correlation analyses were performed to select the microorganisms potentially contributing to this fermentation.RESULTSDuring the fermentation of BS, 162 bacterial and 97 fungal strains were isolated and identified, and a total of 268 314 bacterial and 287 844 fungal high‐quality sequences were analyzed. In general, lactic acid bacteria (LAB), especially Enterococcus and Lactococcus, were dominant in the early stage of fermentation, and spore‐forming bacteria, especially Bacillus spp., became the predominant bacteria by the end of fermentation. Geotrichum, Mortierella, and unclassified Ascomycota, were the major fungal populations, which could not be detected in the final product. Correlation analyses indicated that Enterococcus, Bacillus, Geotrichum, and unclassified Ascomycota correlated significantly and positively with amino nitrogen. However, due to the sporulation characteristics of Bacillus, they may have little effect on BS ripening. The presence of Bifidobacterium spp. in sufu is reported for the first time, but the excessive counts of the Bacillus cereus group (>105 CFU g−1) indicate a potential hazard to consumers.CONCLUSIONThe profiles obtained from this study will contribute to the development of autochthonous starter cultures to control BS fermentation, and may lead to the development of novel strategies to shorten the fermentation time of sufu products. © 2019 Society of Chemical Industry
Optimization of enzyme‐assisted extraction of ferulic acid from sweet corn cob by response surface methodology
Authors: Lau Tiffany , Harbourne Niamh , Oruña‐Concha Maria J 
Published: November 2019

AbstractBACKGROUNDSweet corn cob (SCC), an agricultural by‐product of the corn‐processing industry, contains more than 80% insoluble bound ferulic acid (FA). Extraction of these bound phenolics can be achieved through chemical or enzymatic hydrolysis; however, the shift towards greener chemistry has raised awareness about the use of enzymatic hydrolysis. In the present study, the ability of ferulic acid esterase (FAE) and xylanase (XY) to catalyze the hydrolysis of FA from SCC was investigated. Response surface methodology (RSM), based on a five‐level, four‐factor central composite rotatable design (CCRD), was used to establish the optimum conditions for enzymatic hydrolysis of FA from SCC. Sweet corn cob was treated with a combination of FAE and XY at various concentrations (FAE: 0.00 to 0.04 U/g; XY: 0.00 to 18 093.5 U/g), temperatures (45 to 65 °C), and pH levels (pH 4.5 to 6.5).RESULTSThe optimum extraction conditions predicted by the model were: FAE concentration of 0.02 U/g, XY concentration of 3475.3 U/g, extraction pH of 4.5, and an extraction temperature of 45 °C.CONCLUSIONUnder these conditions, the experimental yield of FA was 1.69 ± 0.02 g kg−1 of SCC, which is in agreement with the value predicted by the model. © 2019 Society of Chemical Industry
Grandmaternal betaine supplementation enhances hepatic IGF2 expression in F2 rat offspring through modification of promoter DNA methylation
Authors: Yang Shu , Zhao Nannan , Sun Bo , Yang Yang , Hu Yun , Zhao Ruqian 
Published: November 2019

AbstractBACKGROUNDWe reported previously that maternal betaine promotes hepatic insulin‐like growth factor (IGF2) expression in F1 offspring rats through hypermethylation of the IGF2/H19 imprinting control region (ICR). It remains unknown whether this acquired trait can be transmitted to the F2 generation. This study aimed to determine whether dietary betaine supplementation to grand dams affects the hepatic IGF2 expression in F2 rat offspring and how it is related to alterations in DNA methylation. F2 rat offspring derived from grand dams fed basal or betaine‐supplemented diet (10 g kg−1) were examined at weaning. Serum IGF2 concentration was measured with enzyme‐linked immunosorbent assay (ELISA). Hepatic expression of IGF2, together with other proliferation and apoptosis markers, was determined by using quantitative polymerase chain reaction (qPCR), western blot, and immunohistochemistry. The methylation status of the IGF2/H19 ICR and the promoters of IGF2 gene were detected by methylated DNA immunoprecipitation quantitative polymerase chain reaction (MeDIP‐qPCR).RESULTSThe maternal betaine‐induced up‐regulation of hepatic IGF2 expression in F1 rat offspring was transmitted to the F2 generation. The F2 rats from the betaine group demonstrated enhanced hepatic IGF2 expression at both mRNA and protein levels, in association with higher serum IGF2 concentration. No alterations were observed in the ICR methylation of the IGF2/H19 locus, and hypomethylation was detected in promoters of IGF2 gene in betaine group.CONCLUSIONThese results indicate that maternal betaine enhances hepatic IGF2 expression in F2 rat offspring through modification of DNA methylation on IGF2 promoters. © 2019 Society of Chemical Industry