bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polyphenolic Fraction Obtained From Thalassia testudinum Marine Plant and Thalassiolin B Exert Cytotoxic Effects in Colorectal Cancer Cells and Arrest Tumor Progression in a Xenograft Mouse Model
Authors: Delgado-Roche Livan , González Kethia , Mesta Fernando , Couder Beatriz , Tavarez Zaira , Zavala Ruby , Hernandez Ivones , Garrido Gabino , Rodeiro Idania , Vanden Berghe Wim 
Published: November 2020

Marine plants are important sources of pharmacologically active metabolites. The aim of the present work was to evaluate the cytotoxic and antitumor activity of a polyphenolic fraction obtained fromThalassia testudinummarine plant and thalassiolin B in human colorectal cancer cells. Human cancer cell lines, including HCT15, HCT116, SW260, and HT29 were treated with tested products for cytotoxicity evaluation by crystal violet assay. The potential proapoptotic effect of these natural products was assessed by flow cytometry in HCT15 cells at 48 h using Annexin V-FITC/propidium iodide. In addition, reactive oxygen species (ROS) generation was measured by fluorescence using DCFH-DA staining, and sulfhydryl concentration by spectrophotometry. Thein vivoantitumor activity of the polyphenolic fraction (25 mg/kg) was evaluated in a xenograft model in nu/nu mice.In vivoproapoptotic effect was also evaluated by immunohistochemistry using anti-caspase 3 and anti-Bcl-2 antibodies. The results showed that tested products exert colorectal cancer cell cytotoxicity. Besides, the tested products induced a significant increase (p&lt; 0.05) of intracellular ROS generation, and a depletion of sulfhydryl concentration in HCT15 cells. The polyphenolic fraction arrested tumor growth and induced apoptosis in the xenograft mice model. These results demonstrate the cytotoxic activity ofT. testudinummetabolites associated, at least, with ROS overproduction and pro-apoptotic effects. Here we demonstrated for the first time the antitumor activity of aT. testudinumpolar extract in a xenograft mice model. These results suggest the potential use ofT. testudinummarine plant metabolites as adjuvant treatment in cancer therapy.
Inappropriate direct oral anticoagulant prescriptions in patients with non-valvular atrial fibrillation: cross-sectional analysis of the French CACAO cohort study in primary care
Authors: Ferrat Emilie , Fabre Julie , Galletout Philippe , Boutin Emmanuelle , Le Breton Julien , Renard Vincent , Frappé Paul , Bastuji-Garin Sylvie 
Published: November 2020

BackgroundDirect oral anticoagulants (DOACs) account for an increasing proportion of prescriptions in patients with non-valvular atrial fibrillation (NVAF) in primary care. Inappropriate dosing of DOACs is a common problem, with under-dosing being a particular issue. However, conflicting results have been reported about the factors independently associated with inappropriate dosing.AimTo describe inappropriate prescriptions of DOACs among patients in the CACAO French nationwide general practice cohort, and to identify the factors independently associated with inappropriate DOAC doses.Design and settingCross-sectional baseline analysis of the CACAO French national multicentre prospective cohort of adult patients in primary care receiving an oral anticoagulant who were recruited between April and October 2014.MethodA total of 1111 patients from the CACAO cohort who received a DOAC for NVAF were included in this study. Inappropriate prescriptions of DOACs were described (inappropriate dosage, contraindications, non-indications, interactions, and non-compliance with the precautions for use). Multivariate logistic models were used to investigate factors associated with inappropriate DOAC dosing (under-dosing and over-dosing).ResultsOverall, 438 patients (39.4%) received at least one inappropriate DOAC prescription. The most common inappropriate prescription was inappropriate dosage (n = 374, 33.7%), particularly under-dosing (n = 348, 31.3%). Multivariate analysis revealed that factors independently associated with under-dosing were older age, prescription of apixaban or dabigatran, and a CHA2DS2-VASc score ≥2 vs. a score = 1. Factors with over-dosing were kidney failure, a HAS-BLED score ≥3, and older age.ConclusionThe appropriateness of DOAC prescribing for NVAF can be improved, especially in older patients, and in patients with kidney failure, a higher risk of ischaemic stroke, and/or a higher risk of bleeding. GPs have a key role in increasing the proportion of appropriate DOAC prescriptions via informational, educational, and/or management strategies.
O Conservatório de Música Lia Salgado e os processos de subjetivação
Authors: Ferrari Anderson , Ferreira Sales Ereny 
Published: November 2020

Com este texto queremos problematizar os processos de subjetivação entendendo-os como educativos, na medida em que são responsáveis pela constituição de sujeitos, envolvendo mecanismos de construção cultural e social. Para isso, elegemos o Conservatório de Música Lia Salgado como campo privilegiado de investigação, dada sua importância para a cidade de Leopoldina/MG e sua vinculação histórica com um projeto de ensino mais abrangente para as artes. Interessa-nos pensar como essa instituição de ensino foi se constituindo e ainda hoje se mantém como espaço de ensino e formação pela música, aproximando-nos da perspectiva de Michel Foucault, que investe na problematização da constituição de sujeitos permeados pelas relações de poder. Para o desenvolvimento da pesquisa, foi utilizada a metodologia de grupo focal com alunos em curso e egressos.
Resiliência e Capacidade de Suporte do Parque Estadual do Ibitipoca (MG)
Authors: Barra Rocha Cézar Henrique , Do Vale Wesley Badoco , Castro Luiz Fernando de Paula , Paravidino José Martins , Da Silva Ana Luíza Fortes , Prado Tamires de Oliveira , Da Silveira Fábio Jacob 
Published: November 2020

A pressão sobre áreas naturais tem aumentado devido ao modelo artificial disponível nas grandes cidades adensadas com concreto e asfalto e desprovidas de áreas verdes. O parque mais visitado de Minas Gerais é o Parque Estadual do Ibitipoca (PEIb), local ímpar e frágil por suas formações em quartzito e que precisa ser monitorado quanto aos impactos das visitações. Apesar da resiliência ao longo dos anos, é necessário medir a sua capacidade de suporte. Este trabalho apresenta a metodologia criada pelo NAGEA a partir da incorporação de novos elementos à Metodologia de Cifuentes (1992) com intuito de conseguir uma melhor adaptação à realidade brasileira. O novo método traz consigo a criação do fator de correção raízes expostas; alteração no fator acessibilidade através da classificação de rampas médias de 10% para 12%; acréscimo da vegetação lateral no fator de correção brilho solar; a conversão de ocorrências pontuais em lineares; e o uso da distância inclinada ao invés da horizontal. Em abril de 2019 no PEIb, foram monitorados os três roteiros disponíveis à visitação: Janela do Céu, Pico do Pião e Águas. Com o uso de receptores GNSS, as trilhas foram mapeadas e ocorrências como alagamentos, desgaste superficial do solo, raízes expostas e trechos com cobertura vegetal. Os dados foram processados, traçando a planta e o perfil longitudinal de cada trilha, determinando as rampas. Com a aplicação da metodologia, foi obtido os seguintes resultados: 959 visitantes diários em todo PEIb, sendo 152 no Circuito das Águas, 457 no Circuito Janela do Céu e 360 no Circuito Pico do Pião. Contudo, as metodologias de capacidade de suporte não são um fim em si, sendo apenas balizadora para estratégias mais abrangentes e integradas com o planejamento e o monitoramento de indicadores de impactos nas áreas protegidas.
PENGARUH NILAI PELANGGAN KUALITAS PELAYANAN TERHADAP KEPUTUSAN PEMILIHAN PENDIDIKAN KAMPUS BERBASIS VOKASI
Authors: Minggu Minggu , Rahmadhani May Vitha , Siswandi Siswandi 
Published: November 2020

<p>This research was conducted to determine how much the influence Customer Value to the College Selection Decision of Student in Polytechnic LP3I Jakarta Kampus Blok M, to determine how much the influence Quality 0f Education Services to the College Selection Decision of Student in Politectic LP3I Jakarta Kampus Blok M, and determine how much the influence Customer Value and Quality of Education services simultaneously to the College Selection Decision of Student in Polytechnic LP3I Jakarta Kampus Blok M. This research was conducted on 75 students out of a population of 300 students using slovin method and quantitative research methods using regression analysis, to prove that the variable customer value has a positive and significant influence towards college selection decisions; and the variable quality of educational services has a positive and significant influence towards college selection decision. The research proved that the customer value has a positif influence 0,823 to the college selection decision,the quality of educational services has a positif influence 0,756 to the college selection decision,customer value and quality of education services simultaneosly has a significant influence 0,854. The Results of this research prove that hypotests Ha accepted and proven linear.</p><p><strong>Keywords: </strong>College Selection Decision, Customer Value, Service Quality</p>
Reflexions about the COVID-19 Pandemic
Authors: Soares Feitosa Gilson 
Published: November 2020

The world has been surprisely caught by an unprecedent pandemic in the last 100 years. The editorial presents the Bill Gates alerted about viral pandemics, as well as the problems faced of all over the world about lack of supplies and million of deaths because of the spreads of SAR-CoV-2 and the illness COVID-19. The editorial also approach the need of a better prepared to face an explosive appearance such as COVID-19 pandemic.
Factors Associated With Length of Stay for Patients With Stroke in Malaysia
Authors: Ismail Aniza , Reffien Muhammad Alimin Mat , Ibrahim Norlinah Mohamed , Sobri Hanani Nabilah Mohd , Abidin Noor Dalila Inche Zainal , Rusli Sharifah Ain Shameera Syed , Selamat Ellyana Mohd 
Published: November 2020

ABSTRACT

Introduction
Globally, stroke continues to become a significant public health issue contributing to one of the significant causes of morbidity and mortality. The study aimed to describe the characteristics of patients with stroke who were admitted to a teaching hospital in Malaysia and to determine the factors associated with length of stay (LOS).

Methods
This is a single-center, cross-sectional study using in-patient data maintained by the Case-Mix Unit of a teaching hospital in Malaysia from 2016 to 2017. The study included all patients with International Classification of Disease (ICD) code 164 (stroke, not specified as hemorrhage or infarct). The significance of association was determined using nonparametric tests in the form of the Mann-Whitney U test and the Kruskal-Wallis test.

Results
A total of 162 stroke patients from 2016 to 2017 from Case-Mix database were included in the study. The age ranged from 31 to 97 years old. The minimum and maximum LOS for patients with stroke ranged from 1 to 17 days. The severity of illness was found to be significantly associated with longer LOS (p &lt; 0.001); however, age, sex, and presence of co-morbidities did not show any significant association.

Conclusion
Despite its limitations, this study is an essential first step to examine the characteristics of patients with stroke and to determine the factors associated with LOS.
Factors Influencing Physicians' Clinical Decision-making at Upazila Health Complexes in Bangladesh
Authors: Islam M. Aminul , Awal M. Abdul 
Published: November 2020

ABSTRACT

Introduction
Selecting the most appropriate treatment for each patient is the key activity in patient-physician encounters and providing healthcare services. Achieving desirable clinical goals mostly depends on making the right decision at the right time in any healthcare setting. But little is known about physicians' clinical decision-making in the primary care setting in Bangladesh. Therefore, this study explored the factors that influence decisions about prescribing medications, ordering pathologic tests, counseling patients, average length of patient visits in a consultation session, and referral of patients to other physicians or hospitals by physicians at Upazila Health Complexes (UHCs) in the country. It also explored the structure of physicians' social networks and their association with the decision-making process.

Methods
This was a cross-sectional descriptive study that used primary data collected from 85 physicians. The respondents, who work at UHCs in the Rajshahi Division, were selected purposively. The collected data were analyzed with descriptive statistics including frequency, percentage, one-way analysis of variance, and linear regression to understand relationships among the variables.

Results
The results of the study reveal that multiple factors influence physicians' decisions about prescribing medications, ordering pathologic tests, length of visits, counseling patients, and referring patients to other physicians or hospitals at the UHCs. Most physicians prescribe drugs to their patients, keeping in mind their purchasing capacity. Risk of violence by patients' relatives and better management are the two key factors that influence physicians' referral decisions. The physicians' professional and personal social networks also play an influential role in the decision-making process. It was found that physicians dedicate on average 16.17 minutes to a patient in a consultation session. The length of visits is influenced by various factors including the distance between the physicians' residence and their workplace, their level of education, and the number of colleagues with whom they have regular contact and from whom they can seek help.

Conclusion
The results of the study have yielded some novel insights about the complexity of physicians' everyday tasks at the UHCs in Bangladesh. The results would be of interest to public health researchers and policy makers.
Modeling the transport of radioactive pollution in the Ussuri Gulf during the first days after the nuclear accident in the Chazhma Bay in August 1985
Authors: ФАЙМАН П.А. , БУДЯНСКИЙ М.В. , УЛЕЙСКИЙ М.Ю. , ПРАНЦ С.В. , ВЫСОЦКИЙ В.Л. , ПРИПАЧКИН Д.А. 
Published: November 2020

Представлены результаты лагранжевого моделирования распространения радиоактивного загрязнения в Уссурийском заливе на различных горизонтах по глубине на основе численной региональной модели циркуляции ROMS с использованием эмпирических данных выпадения радиоактивных осадков из атмосферы на поверхность акватории в день аварии на атомной подводной лодке в бухте Чажма 10 августа 1985 г. Показано, что радиоактивное пятно могло оставаться в Уссурийском заливе в течение первых четырех суток после аварии. Установлено, что эволюция и деформация начального пятна загрязнения на разных горизонтах обусловлены влиянием вихрей разных полярностей и размеров (мезомасштабный циклон в центре залива, субмезомасштабный антициклон на севере и мезомасштабный антициклон на юге) и лагранжевых когерентных структур, связанных с гиперболическими точками в заливе.
The results of Lagrangian modeling of the transport of radioactive pollution in the Ussuri Gulf at various depths based on a regional ROMS numerical model of circulation using the empirical data on the radioactive fallout from the atmosphere at the sea surface on the day of the accident at a nuclear submarine in the Chazhma Bay in August 10, 1985. It was shown that the radioactive particles remain in the Ussuri Gulf for the first 4 days after the accident. It has been shown that the evolution and deformation of the initial pollution patch on various horizons was influenced by vortices of different polarity and size in the Ussuri Gulf (a mesoscale cyclone in the center of the Gulf, a sub-mesoscale anticyclone in the north and a mesoscale anticyclone in the south) and by Lagrangian coherent structures connected with hyperbolic points in the Gulf.
The Influence Of Massage On Sleep Quality In Children's Pre-School
Authors: Suhariati Hindyah Ike , Yuswatiningsih Endang 
Published: November 2020

Introduction: Sleep disturbance is one of the problems that is often encountered in preschool children. About 44,2% of preschoolers experience sleep disorders. Sleep disorders can affect children's behavior and emotions, cause drowsiness during the day, reduce children's attention at school, get tired easily, reduce physical activity, reduce memory, children become fussy and temper tantrums. The purpose of this study is to analyze the effect of giving massage to sleep quality in preschool children in a Kindergarten in Lawang Hospital.
Methods: The design in this study is the Pre-Experiment (Pre and Post-test design). The Affordable population is all preschool age children in a Kindergarten in Lawang who have 45 sleep disorders, the sample in this study amounted to 35 children. The sampling technique used was Simple Random Sampling. Analysis of paired data (pre and post-test) on sleep quality variables used the Wilcoxon test. If the statistical test results obtained p <0.05, then H1 is accepted, it means the research hypothesis is accepted.
Results: The results showed the quality of sleep before giving massage mostly poor, the quality of sleep after giving massage is mostly good, there is an effect of giving massage to the quality of sleep in preschool children in a Kindergarten in Lawang.
Conclusion: The study concludes that there is an effect of giving massage to the quality of timber in preschool children in a Kindergarten in Lawang.
The The Correlation of Hemodynamic Status and Oxygen Saturation with The Level of Consciousness in Head Injury Patients
Authors: Kumalasari Nuril , Marsaid  , Palupi Lingling Marinda 
Published: November 2020

Introduction: Head injury is a traumatic disorder caused by the mechanical strength of a blunt object or penetration that can cause temporary or permanent changes in tissue function and structure. The latest developing concept on poor prognosis among head injury patients was occur related to the secondary injuries, where there was an increase in intracranial, cerebral ischemia, and decreased consciousness. The important thing in the management of head injuries is to maintain hemodynamic stability and to prevent hypoxia by maintaining oxygen saturation >95%. The purpose of this study was to analyze the correlation of hemodynamic status and oxygen saturation with the level of consciousness in head injury patients at RSUD Mardi Waluyo, Blitar.
Methods: The research used correlational analytical with a cross-sectional design. The sampling technique used consecutive sampling within a total sample of 30 respondents. Spearman's test was used for data analysis.
Results: The results showed a correlation between mean arterial pressure (p-value = .004), respiratory rate (p-value = .000), body temperature (p-value = .017), and oxygen saturation (p-value = .000) with level of consciousness (GCS) respectively.
Conclusion: It can be concluded that mean arterial pressure, respiratory rate, body temperature, and oxygen saturation can affect the level of consciousness (GCS). There was a need to improve hemodynamic and oxygen saturation monitoring to prevent the bad prognosis in head injury patients at RSUD Mardi Waluyo, Blitar.
The ongoing search for the oldest rock on the Danish island of Bornholm: new U-Pb zircon ages for a quartzrich xenolith and country rock from the Svaneke Granite
Authors: Waight Tod E. , Serre Simon H. , Næsby Sebastian H. , Thomsen Tonny B. 
Published: November 2020

Previous geochronological studies on the Danish island of Bornholm have not identified any rocks older than c. 1.46 Ga. New LA-ICP-MS U-Pb zircon ages are presented for a xenolith within, and the country rock gneiss adjacent to, the Svaneke Granite on Bornholm. The xenolith is fine-grained and quartz-rich and was likely derived from either a quartz-rich sedimentary protolith or a hydrothermally
altered felsic volcanic rock. The relatively fine-grained felsic nature of the country rock gneiss and the presence of large zoned feldspars that may represent phenocrysts suggest its protolith may have been a felsic volcanic or shallow intrusive rock. A skarn-like inclusion from a nearby locality likely represents an originally carbonate sediment and is consistent with supracrustal rocks being present at least locally. Zircon data from the xenolith define an upper intercept age of 1483 ± 12 Ma (2σ, MSWD = 2.5) with a poorly defined lower intercept age of 474 ± 250 Ma, and a weighted average 207Pb/206Pb age of 1477.9 ± 4.6 Ma; both these ages are older than the host Svaneke Granite (weighted average 207Pb/206Pb age of 1465.0 ± 4.8 Ma). Zircons from the gneiss define an upper intercept age of 1477.7 ± 6.8 Ma when anchored at 0 Ma, and a weighted average 207Pb/206Pb age of 1475.4 ± 6.6 Ma which overlaps statistically with the Svaneke Granite age. These ages are currently the oldest ages determined for in situ rocks on Bornholm. Evidence for substantially older basement lithologies (e.g. 1.8 Ga as observed in southern Sweden) remains absent. The zircons display clear oscillatory zoning, have Th/U typical of magmatic zircons and in some cases preserve inherited cores, all of which suggest that the ages are robust and do not represent resetting due to incorporation within or intrusion by the Svaneke Granite. Inherited zircons are not common; they have ages (c. 1.6–1.8 Ga) that are similar to those observed in other felsic basement lithologies on Bornholm. These new
results suggest that prior to intrusion of the Svaneke Granite, the upper crust on Bornholm was dominated, at least locally, by lithologies similar in composition to the currently exposed felsic basement. The protoliths to the two samples investigated here must have been buried to mid-crustal depths over a relatively short time period (c. 10 Ma) prior to intrusion of the Svaneke Granite. This
suggests a dynamic tectonic environment and is consistent with evidence for broadly simultaneous magmatism and deformation in basement rocks at 1.46 Ga in southern Scandinavia and burial and metamorphism of sediments in southern Skåne.