bluuebunny/crossref_metadata_2025_split huggingface dataset:
XENOBREAST Trial: A prospective study of xenografts establishment from surgical specimens of patients with triple negative or luminal b breast cancer
Authors: Veyssière Hugo , Passildas Judith , Ginzac Angeline , Lusho Sejdi , Bidet Yannick , Molnar Ioana , Bernadach Maureen , Cavaille Mathias , Radosevic-Robin Nina , Durando Xavier 
Published: October 2020

Introduction: Patient-derived xenografts (PDX) can be used to explore tumour pathophysiology and could be useful to better understand therapeutic response in breast cancer. PDX from mammary tumours are usually made from metastatic tumours. Thus, PDX from primitive mammary tumours or after neoadjuvant treatment are still rare. This study aims to assess the feasibility to establish xenografts from tumour samples of patients with triple negative or luminal B breast cancer in neoadjuvant, adjuvant or metastatic setting. Methods: XENOBREAST is a single-centre and prospective study. This feasibility pilot trial aims to produce xenografts from tumour samples of patients with triple negative or luminal B breast cancer. Patient enrolment is expected to take 3 years: 85 patients will be enrolled and followed for 28 months. Additional blood samples will be taken as part of the study. Surgical specimens from post-NAC surgery, primary surgery or surgical excision of the metastases will be collected to establish PDX. Histomolecular characteristics of the established PDX will be investigated and compared with the initial histomolecular profile of the collected tumours to ensure that they are well-established. Ethics and dissemination: XENOBREAST belongs to category 2 interventional research on the human person. This study has been approved by the Sud Méditerranée IV – Montpellier ethics committee. It is conducted notably in accordance with the Declaration of Helsinki and General Data Protection Regulation (GDPR). Study data and findings will be published in peer-reviewed medical journals. We also plan to present the study and all data at national congresses and conferences. Registration: ClinicalTrials.gov ID NCT04133077; registered on October 21, 2019.
Joaquín Dicenta y Luis Bonafoux, dos precursores del periodismo narrativo en España
Authors: Del Arco Bravo Miguel Ángel 
Published: October 2020

Este artículo reivindica las figuras de dos precursores del periodismo narrativo español en los alrededores de 1900: Joaquín Dicenta y Luis Bonafoux. Dicenta, quien además de periodista fue un autor teatral de éxito, se adelantó en varias décadas a George Orwell al relatar la vida cotidiana de los mineros, publicada por entregas en El Liberal. Bonafoux alcanzó fama como cronista y se anticipó a las coberturas en vivo por Twitter al publicar sus telegramas sobre el caso Dreyfus desde París para El Heraldo de Madrid. Estos cronistas de la bohemia modernista merecen, pues, ser rescatados del olvido e incorporados al canon del periodismo literario español.
As pesquisas sobre professores iniciantes: uma revisão integrativa
Authors: Almeida Patrícia Cristina Albieri de , Reis Adriana Teixeira , Gomboeff Ana Lucia Madsen , André Marli Eliza Dalmazo Afonso de 
Published: October 2020

Este texto apresenta uma revisão integrativa da literatura em que se buscou analisar as tendências dos estudos sobre o professor iniciante e identificar se e como as produções têm indicado, a partir dos resultados das pesquisas, recomendações para promover a inserção profissional dos docentes no início da carreira. Optou-se por realizar o levantamento no período de 2000 a 2019 e tomou-se, como corpus de análise, os trabalhos apresentados nas reuniões anuais da Anped, as dissertações e teses disponíveis no catálogo de Teses e Dissertações da Capes e, ainda, os artigos disponíveis no website do SciELO e do Educ@. Destacam-se nos achados da revisão que, depois de 2014, houve um aumento importante de publicações sobre o tema. Nesse período mais recente emergiu o interesse pelo estudo com egressos de programas públicos de iniciação à docência na formação inicial com destaque ao Pibid e de ações de formação continuada propostas em secretarias estaduais e municipais. Aumentaram, também, os trabalhos com foco nas ações formativas de apoio e acompanhamento ao professor que ingressa na profissão, destacando-se as contribuições do uso de dispositivos de formação e dos grupos colaborativos. Por outro lado, persistem algumas lacunas e conclui-se que ainda há muito que aperfeiçoar nas pesquisas para que haja uma contribuição efetiva na constituição do campo, pois são poucos os estudos que problematizam seus resultados, aprofundam as análises e interpretações, de modo que se possa gerar um conhecimento mais abrangente e consistente permitindo indicar caminhos, ações e práticas que favoreçam a inserção profissional dos docentes.
Evaluation the Effect of Different Antioxidants Applied After Bleaching on Teeth Color Stability
Authors: Degirmenci Alperen , Kara Emine , Unalan Degirmenci Beyza , Ozcan Mutlu 
Published: October 2020

Objective: Vital bleaching is popular treatment option for discolored teeth. But at post-treatment stage, loss of adhesion is highly reported. Literature focused on antioxidant application for the answer of this issue. The aim of this study is comparing effects of six different antioxidants on color stability of bleached teeth. Material and Methods: This study includes total of 84 extracted intact non-carious lower incisors. 35% hydrogen peroxide was applied on the labial surfaces of specimens in accordance with manufacturer's instructions. The bleached teeth were divided into 7 groups. No antioxidants were applied to the control group. For the experimental groups, the following antioxidants were applied for 10 minutes each: 5% proanthocyanidin, 5% sodium ascorbate, 5% lycopene, %5 green tea, %5 white tea and %5 ?-tocopherol. CIE L*, a* and b* values of the teeth were measured by a spectrophotometer. The data were analyzed using IBM SPSS version 23. Results: The differences between the groups were determined with one-way ANOVA. The one-way ANOVA test revealed a statistically significant difference between the groups (p<0.005). Highest color change was observed in lycopene group and the lowest was belongs to green tea group. Conclusions: Proanthocyanidin, white tea and green tea could be good post-bleaching antioxidant alternatives based on their herbal nature.
Contrasting Clinician and Insurer Perspectives to Managing Irritable Bowel Syndrome: Multilevel Modeling Analysis
Authors: Shah Eric D. , Chang Lin , Salwen-Deremer Jessica K. , Gibson Peter R. , Keefer Laurie , Muir Jane G. , Eswaran Shanti , Chey William D. 
Published: October 2020

INTRODUCTION:
Insurance coverage is an important determinant of treatment choice in irritable bowel syndrome (IBS), often taking precedence over desired mechanisms of action or patient goals/values. We aimed to determine whether routine and algorithmic coverage restrictions are cost-effective from a commercial insurer perspective.

METHODS:
A multilevel microsimulation tracking costs and outcomes among 10 million hypothetical moderate-to-severe patients with IBS was developed to model all possible algorithms including common global IBS treatments (neuromodulators; low fermentable oligo-, di-, and mono-saccharides, and polyols; and cognitive behavioral therapy) and prescription drugs treating diarrhea-predominant IBS (IBS-D) or constipation-predominant IBS (IBS-C) over 1 year.

RESULTS:
Routinely using global IBS treatments (central neuromodulator; low fermentable oligo-, di-, and mono-saccharides, and polyols; and cognitive behavioral therapy) before US Food and Drug Administration-approved drug therapies resulted in per-patient cost savings of $9,034.59 for IBS-D and $2,972.83 for IBS-C over 1 year to insurers, compared with patients starting with on-label drug therapy. Health outcomes were similar, regardless of treatment sequence. Costs varied less than $200 per year, regardless of the global IBS treatment order. The most cost-saving and cost-effective IBS-D algorithm was rifaximin, then eluxadoline, followed by alosetron. The most cost-saving and cost-effective IBS-C algorithm was linaclotide, followed by either plecanatide or lubiprostone. In no scenario were prescription drugs routinely more cost-effective than global IBS treatments, despite a stronger level of evidence with prescription drugs. These findings were driven by higher prescription drug prices as compared to lower costs with global IBS treatments.

DISCUSSION:
From an insurer perspective, routine and algorithmic prescription drug coverage restrictions requiring failure of low-cost behavioral, dietary, and off-label treatments appear cost-effective. Efforts to address insurance coverage and drug pricing are needed so that healthcare providers can optimally care for patients with this common, heterogenous disorder.
Simulation study of signal gain optimization based on hybrid composition techniques for high-speed optically dense multiplexed systems
Authors: Eid Mahmoud M. A. , Rashed Ahmed Nabih Zaki , El-Meadawy Shimaa , Ahmed Kawsar 
Published: October 2020

Abstract
This study created a 13 Gb/s transmission speed per 300 channel dense wavelength division multiplexing system based on hybrid optical fiber amplifiers and filter techniques to enhance signal gain. The filter techniques used here included a hybrid optical amplifier, a gain flattening filter (GFF), a Fabry–Perot filter, a fiber Bragg grating (FBG), and glass composition technique. The techniques were combined to optimize signal gain as follows: the study began with an erbium-doped fiber amplifier (EDFA), added a Raman amplifier, added GFF, added fiber Bragg grating, added glass composition, and finally achieved a hybrid-modified model after adding Fabry–Perot filter. The signal gain was optimized with the hybrid-modified model via the different operating parameters of the EDFA. The proposed model also showed a better performance (30–40 dB greater) than the previous model (Mahran O, Aly MH. Performance characteristics of dual-pumped hybrid EDFA/Raman optical amplifier. OSA – Applied Optics Jan 2016;55:22–6) after changing the values of the signal wavelength, the EDFA, and the length of the Raman amplifier.
Utility of a Shortened Isometric Midthigh Pull Protocol for Assessing Rapid Force Production in Athletes
Authors: Suarez Dylan G. , Carroll Kevin M. , Slaton Jake A. , Rochau Kyle G. , Davis Michael W. , Stone Michael H. 
Published: October 2020

Abstract
Suarez, DG, Carroll, KM, Slaton, JA, Rochau, KG, Davis, MW, and Stone, MH. Utility of a shortened isometric midthigh pull protocol for assessing rapid force production in athletes. J Strength Cond Res 36(7): 1819–1825, 2022—The purpose of this investigation was to determine the magnitude of difference, reliability, and relationship to performance of a shortened isometric midthigh pull (IMTP) protocol. Fourteen strength-trained men (age: 26.8 ± 5.0 years, height: 176.3 ± 6.9 cm, body mass: 86.8 ± 13.9 kg, and training age: 8.5 ± 6.9 years) performed 1-second (SHORT) and traditional (TRAD) IMTP protocols during consecutive weeks. Peak force (PF), instantaneous force (90 & 200 ms), rate of force development (RFD) (0–90 ms & 0–200 ms), and impulse (0–90 ms & 0–200 ms) from each protocol were collected. Paired samples t test and Hedge's g were calculated to determine the magnitude of difference in each variable between protocols. Within-session and between-session reliability was assessed with intraclass correlation coefficient, coefficient of variation, and 95% confidence intervals. Static jumps were performed to compare relationships of the IMTP variables from each protocol with jumping performance. There was no statistically significant (p > 0.05) difference in PF between the protocols (p = 0.345; g = −0.07). All early force-time variables were significantly higher in the SHORT protocol (p = <0.001–0.018; g = 0.38–0.79). The SHORT protocol resulted in more reliable RFD measures within-session. Correlations with jumping performance were mostly similar between protocols (r = 0.253–0.660). The SHORT IMTP protocol resulted in comparable PF values and considerably higher early force-time characteristics despite a restrained time to produce force and shorter rest. The SHORT protocol allows for an accurate assessment of rapid force-generating abilities while necessitating shorter collection periods than typical IMTP protocols.
Stretch-Shortening Cycle Function of Lower Limbs After Cycling in Triathletes
Authors: Takahashi Keigo , Shirai Yusuke , Nabekura Yoshiharu 
Published: October 2020

Abstract
Takahashi, K, Shirai, Y, and Nabekura, Y. Stretch-shortening cycle function of lower limbs after cycling in triathletes. J Strength Cond Res 36(9): 2610–2614, 2022—Impaired cardiorespiratory response and changes in biomechanical variables occur when running after cycling relative to isolated running. Nevertheless, little is known about the causes of these changes or the training to prevent them. This study aimed (a) to determine whether stretch-shortening cycle (SSC) function decreases after cycling exercise and (b) to determine whether the decreases in SSC function are related to brick training. Eleven male university triathletes performed hopping tests to measure SSC function before and after cycling (30 minutes of cycling at 110% ventilatory threshold). Stretch-shortening cycle function was calculated as the ratio of the jump height to the time spent in contact with the ground (reactive strength index [RSI]). Brick training was evaluated by the total experience of brick training. The RSI significantly decreased after the cycling exercise (−10.7%; p < 0.01), but changes in RSI after cycling did not significantly correlate with the total experience of brick training, despite a large effect size (p < 0.10; r = 0.62). These results suggest that SSC function decreases after cycling and that brick training is potentially useful for inhibiting decreases in SSC function after cycling.
A Retrospective Analysis of the National Youth Teams in Volleyball: Were They Always Faster, Taller, and Stronger?
Authors: Mostaert Mireille , Pion Johan , Lenoir Matthieu , Vansteenkiste Pieter 
Published: October 2020

Abstract
Mireille, M, Johan, P, Matthieu, L, and Pieter, V. A retrospective analysis of the national youth teams in volleyball: Were they always faster, taller, and stronger? J Strength Cond Res 36(9): 2615–2621, 2022—Although there are numerous studies comparing the characteristics of young and adult volleyball players of different levels, it remains unclear to what extent these findings can be used for performance prediction because very few are based on longitudinal or retrospective analyses. The aim of the current retrospective study was to test to what extent anthropometry, physical performance, and motor coordination can predict future selection in national youth teams. From 2012 to 2015, 1738 10- to 13-year-old boys and girls who played volleyball completed 3 anthropometric, 4 physical performance, and 3 motor coordination tests. In January 2020, 52 athletes of this sample were found to be part of one of the national youth teams of Belgium. A multivariate analysis of covariance, discriminant analyses, and logistic regression analyses were conducted to compare the test results of the selected vs. the nonselected players. Significance level was set at p ≤ 0.05. Results showed that the selected players were already taller and showed better jumping performance, and for females, they tended to have better motor coordination at the time of baseline measurement. Therefore, it seems important to focus on the development of motor coordination and jumping performance at young ages because superiority in these characteristics increases the chances to be selected for the national team 4–8 years later. Nevertheless, considering the large variation in results, selection cannot be made based on these characteristics alone. The practical implications for coaches and federations with respect to training and talent detection are discussed.
Settled
Authors: Rudy Jason R. 
Published: October 2020

Jason R. Rudy, “Settled: Dorrit Down Under” (pp. 184–206)
Although the conclusion to Charles Dickens’s Little Dorrit (1855–57) finds the protagonists Arthur Clennam and Amy Dorrit comfortably situated in London, the novel’s long and meandering narrative entertains alternate possibilities. This essay considers the relation of emigration to British middle-class identity, both in the historical context of the 1850s and in the fictional world of Dickens’s novel. Australian free emigration, which saw a significant rise in the 1850s, serves as a limit case against which to test the significance of remaining at home in England. Little Dorrit is a novel that “settles” on a domestic life of bourgeois stability, but it arrives at this conclusion only after contemplating less-predictable futures abroad. Dickens himself considered emigrating to Australia while writing Little Dorrit, and the novel’s quiet conclusion reflects the author’s own conflicted resolution to forego life beyond British shores. Dickens’s novel ultimately suggests that Victorian middle-class stability depended at least in part on the rejection of economic possibilities abroad.
Pubertal induction in adolescents with DMD is associated with high satisfaction, gonadotropin release and increased muscle contractile surface area
Authors: Wood Claire L , Hollingsworth Kieren G , Hughes Eric , Punniyakodi Sadhanandham , Muni-Lofra Robert , Mayhew Anna , Mitchell Rod T , Guglieri Michela , Cheetham Timothy D , Straub Volker 
Published: October 2020

Background
Pharmacological doses of glucocorticoids (GC) reduce inflammation and preserve muscle function in boys with Duchenne muscular dystrophy (DMD). Delayed puberty and bone fragility are consequences of GC treatment. The aim of this study was to determine the acceptability of a 2-year pubertal induction regimen using 4-weekly testosterone injections and examine changes in physique, bone integrity, muscle pathology (assessed by MRI) and muscle function.

Methods
Fifteen prepubertal males with DMD, aged 12–17 years and receiving GC, were treated with an incremental testosterone regimen for 2 years. Participants completed a Treatment Satisfaction Questionnaire (TSQM). Data on BMI, bone density, muscle pathology and function were collected at baseline and 2 years later.

Results
Testosterone injections were well tolerated, with high TSQM scores. Baseline BMI z-score was 2.16 (0.90) and 1.64 (1.35) 2 years later. Median testosterone levels were 9.7 nmol/L (IQR: 5.7–11.1) 6–9 months after the last injection with an associated increase in testicular volume. Lumbar spine z-score was 0.22 (s.d. 2.21) at baseline and 0.35 (s.d. 2.21) after 2 years. Upper and lower limb muscle contractile cross-sectional area increased in all participants during the trial (P = 0.05 and P < 0.01, respectively). There was a reduction in T2 relaxation times in most muscle groups with stable upper limb muscle function.

Conclusion
Incremental monthly testosterone injections were well tolerated, promoted endogenous testosterone production and had a positive impact on the skeleton and contractile muscle bulk with evidence suggesting a beneficial impact on the underlying disease process.
Dehydrated Caenorhabditis elegans Stocks Are Resistant to Multiple Freeze-Thaw Cycles
Authors: McClanahan Patrick D , McCloskey Richard J , Ng Tung Hing Melanie , Raizen David M , Fang-Yen Christopher 
Published: October 2020

Abstract
Ultracold preservation is widely used for storage of genetic stocks of Caenorhabditis elegans. Current cryopreservation protocols are vulnerable to refrigeration failures, which can result in the loss of stock viability due to damage during re-freezing. Here we present a method for preserving worms in a dehydrated and frozen form that retains viability after multiple freeze-thaw cycles. After dehydration in the presence of trehalose or glycerol, C. elegans stocks can be frozen and thawed multiple times while maintaining viability. While both dauer and non-dauer larvae survive desiccation and freezing, the dauer defective mutant daf-16 does not survive desiccation. Our technique is useful for storing stocks in a manner robust to freezer failures, and potentially for shipping strains between laboratories.
A STUDY OF PROSPECTIVE TEACHER’S RESILIENCE OF B.ED. COLLEGES OF MEHSANA CITY
Authors: Parihar Prashant B. , Tiwari Tripti 
Published: October 2020

Prospective Teacher’s resilience has been conceptualized in terms of prospective teacher’s ability to handle change, difficult situations, chaos in life, or manage the stress of his or her environment while thriving in the face of adversity. The present research study focuses to examine the significance of difference between the mean scores of independent variables on prospective teacher’s resilience. The objectives of the study were; (i) to study the significance of difference of mean scores of following independent variables on prospective teacher’s resilience: (a) Gender; (b) Caste (c) Types of College and (d) Discipline. Null hypotheses were framed. Data were collected from 244 prospective teachers by incidental sampling technique from four teacher education colleges i.e. B.Ed. colleges of Mehsana district using self-constructed Resilience Scale. Mean, S.D. and t-value were employed for data calculation and analysis. The findings of the present research study indicated no statistically significant difference between the mean scores of subsets of Gender, Caste, and Types of College. But, the Prospective Teachers of Commerce were found to be significantly higher at .01 level of significance than Prospective Teachers of Arts and Prospective Teachers of Science on mean scores (3.116≥ 2.58) of Resilience Scale. Practical implications of the study are discussed in relation to increasing resilience among students of different disciplines.