bluuebunny/crossref_metadata_2025_split huggingface dataset:
Academic burnout and student engagement: a moderated mediation model of internal locus of control and loneliness
Authors: Singh Lata Bajpai , Kumar Alok , Srivastava Shalini 
Published: December 2020

Purpose
This paper aims to assess the relationship between academic burnout-student engagement relationships on management students of the Delhi-NCR region of Northern India. It further attempts to study the moderating impact of internal locus of control and mediating impact of loneliness on the academic burnout-student engagement relationship.

Design/methodology/approach
The data was collected using standardized instruments from 264 respondents. Descriptive statistics, correlation and moderated-mediated regression analysis were used to test the hypotheses.

Findings
The study found a negative association between student engagement and academic burnout and loneliness. A positive association between academic burnout and loneliness and a moderating impact of internal locus of control on academic burnout and student engagement relationship. Loneliness acted as a partial mediator for the moderated relationship between the academic burnout-student engagement relationship.

Research limitations/implications
Sample size and sampling units are the limitations of the study.

Practical implications
The conclusion of the presented study offers different inferences including validating the self-determination theory (Ryan and Deci, 2000) and possible courses of actions to be taken by academic institutions and students themselves. It ranges from careful investigation of student’s behaviors, design and implements collaborative projects along with student’s involvement in social networking based groups for collaborations and help.

Social implications
With the help of the study, the society including parents, family, friends, officials and academicians at educational institutions can offer useful insights to students through recreational and social activities for behavior modifications.

Originality/value
The major contribution of the study is to understand the psyche of the budding professionals perceiving increased stress and pressure. Limited studies are found in the Indian context and no studies in the past have used the study variables together. Internal locus of control as a personality variable has not been studied with respect to student’s burnout and engagement. Furthermore, none of the studies done in the past have deliberated upon loneliness with respect to the student community.
Tutor and international student perspectives on an action research project: use of a business strategy simulation with mixed nationality cohorts
Authors: Kerridge Clive R. , Simpson Colin 
Published: December 2020

Purpose
This study aims to present the results of a curriculum design intervention, which was undertaken to address the inhibitors and enablers facing international (mainly Chinese) students on a capstone undergraduate strategic management module at a UK university business school.

Design/methodology/approach
Using an action research approach, the pre-intervention phase identified two main concerns: low levels of student engagement and avoidance of generic academic and language support. The module was subsequently redesigned around a group-based strategic business simulation (requiring collaborative participation of all students), with embedded language and academic support, plus the involvement of bilingual teaching staff.

Findings
Post-intervention results from the four-year study indicated enhanced academic engagement of international students and a narrowing of the performance (grade) gap between domestic and international students.

Practical implications
Overall findings should provide strong support for the inclusion of active learning pedagogies in undergraduate business course deliveries, also complementing educational literature that advocates the effectiveness of constructivist pedagogies in mixed-nationality classrooms.

Originality/value
This study exemplifies a form of participatory action research. The juxtaposition of comments from support and specialist tutors, along with those of students, highlights the validity of views from each stakeholder group.
Negotiation of needs towards halal talents sustainability
Authors: Abdul Rahim Norhayati Rafida , Abdullah Ismail , Yahya Noor Azrina , Awang Muhammad Nizam , Muhammad Siti Zubaidah , Ahmad Sabri Safiyyah , Ahmad Norfaizah Nadhrah 
Published: December 2020

Purpose
This study aims to identify the negotiation parameters of needs for Halal talents in Malaysia and proffer solutions on the sustainability of halal talents in Malaysia.

Design/methodology/approach
A focus group discussion was performed among seven Halal talents from the industries of various schemes. Using the theory of inventive problem solving (TRIZ) analysis approach, a functional model, as well as causes and effect analysis, is generated by the participants. The model is translated into a contradiction matrix to obtain the necessary solutions in developing a sustainable framework for Halal Talents in Malaysia.

Findings
The cause-and-effect analysis reveals that poor career path, lack of training and poor salary structure are experienced by the participants.

Research limitations/implications
Having had vast categories of halal industries, this research focuses on nine schemes under halal certification JAKIM which excludes banking and tourism.

Practical implications
It is suggested that the implementation of mutual benefits should be in place to enhance positivism among Halal talents in the near future.

Originality/value
Unlike the social science approach, the use of TRIZ analysis provides a substantial framework of sustainability among halal talents in Malaysia.
Environmental drivers of plankton protist communities along latitudinal and vertical gradients in the oldest and deepest freshwater lake
Authors: David Gwendoline M. , Moreira David , Reboul Guillaume , Annenkova Nataliia V. , Galindo Luis J. , Bertolino Paola , López‐Archilla Ana I. , Jardillier Ludwig , López‐García Purificación 
Published: December 2020

SummaryIdentifying which abiotic and biotic factors determine microbial community assembly is crucial to understand ecological processes and predict how communities will respond to environmental change. While global surveys aim at addressing this question in the world's oceans, equivalent studies in large freshwater systems are virtually lacking. Being the oldest, deepest and most voluminous freshwater lake on Earth, Lake Baikal offers a unique opportunity to test the effect of horizontal versus vertical gradients in community structure. Here, we characterized the structure of planktonic microbial eukaryotic communities (0.2–30 μm cell size) along a North–South latitudinal gradient (~600 km) from samples collected in coastal and pelagic waters and from surface to the deepest zones (5–1400 m) using an 18S rRNA gene metabarcoding approach. Our results show complex and diverse protist communities dominated by alveolates (ciliates and dinoflagellates), ochrophytes and holomycotan lineages, with cryptophytes, haptophytes, katablepharids and telonemids in moderate abundance and many low‐frequency lineages, including several typical marine members, such as diplonemids, syndinians and radiolarians. Depth had a strong significant effect on protist community stratification. By contrast, the effect of the latitudinal gradient was marginal and no significant difference was observed between coastal and surface open water communities. Co‐occurrence network analyses showed that epipelagic communities were significantly more interconnected than communities from the dark water column and suggest specific biotic interactions between autotrophic, heterotrophic and parasitic lineages that influence protist community structure. Since climate change is rapidly affecting Siberia and Lake Baikal, our comprehensive protist survey constitutes a useful reference to monitor ongoing community shifts.
Evaluation of latent fingermark color contrast as aging parameter under different environmental conditions: A preliminary study
Authors: De Alcaraz‐Fossoul Josep , Zapico Sara C. , Dean Emily R. , Mueller Katherine E. , Johnson Cathy , Roberts Katherine A. 
Published: December 2020

AbstractThis research expands previous studies in which color contrast between ridges and furrows of powder‐enhanced latent fingermarks was explored as a possible aging parameter. The main goal is to test the sensitivity of the technique across a predetermined set of factors. In this case, experiment factors have included two donors who deposited sebaceous‐ and eccrine‐rich fingermarks onto ceramic tile and polystyrene plastic. These were developed with either black carbon or titanium dioxide powder (TiO2) over eight time periods (0–72 days) and aged under three light conditions (direct light, shade, and darkness). The mean intensity (MI) and intensity amplitude (IA) metrics of color were collected from each image for statistical analyses. Results show that color contrast is affected significantly by substrate, secretion, and powder types, with an interaction effect between the substrate and powder type on both MI and IA metrics. The degree of light exposure did not have a noticeable impact on distinguishing aging patterns of fingermarks by neither powder methods. Different aging patterns were detected between sebaceous‐rich and their eccrine‐rich counterparts for all light conditions using regression analysis. All eccrine‐rich fingermarks exhibited little (or minimal) change in IA over time, whereas sebaceous‐rich samples showed varied patterns, from significant decreases to slight increases. These findings confirm and expand previous observations on the potential use of MI and IA as metrics to study latent fingermark degradation patterns that could eventually be used to estimate the age of a fingermark.
Short‐term local control after VATS segmentectomy and lobectomy for solid NSCLC of less than 2 cm
Authors: Darras Marc , Ojanguren Amaya , Forster Céline , Zellweger Matthieu , Perentes Jean Yannis , Krueger Thorsten , Gonzalez Michel 
Published: December 2020

AbstractIntroductionVATS pulmonary segmentectomy is increasingly proposed as a parenchyma‐sparing resection for tumors smaller than 2 cm in diameter. The aim of this study was to compare short‐term oncological results and local control in solid non‐small cell lung cancers (NSCLCs) <2 cm surgically treated by intentional VATS segmentectomy or lobectomy.MethodsThis study was a single center retrospective study of consecutive patients undergoing VATS lobectomy (VL) or segmentectomy (VS) for solid <2 cm NSCLC from January 2014 to October 2019.ResultsIn total, 188 patients with a median age of 65 years (male/female: 99/89) underwent VS (n = 96) or VL (n = 92). Segmentectomies in the upper lobes were performed in 57% and as a single segment in 55% of cases. There was no statistically significant difference between VS and VL in terms of demographics, comorbidities, postoperative outcomes, dissected lymph node stations (2.89 ± 0.95 vs. 2.93 ± 1, P = 0.58), rate of pN1 (2.2% vs. 2.1%, P = 0.96) or pN2 upstaging (1.09% vs. 1.06%, P = 0.98). Adjuvant chemotherapy was given in 15% of patients in the VL and 11% in the VS group. During follow‐up (median: 23 months), no patients presented with local nodal recurrence or on the stapler line (VS group). Three patients on VL and two in VS groups presented with recurrence on the remnant operated lung. New primary pulmonary tumors were diagnosed in 3.3% and 6.3% of patients in the VL and VS groups, respectively.ConclusionsDespite the short follow‐up, our preliminary data shows that local control is comparable for VATS lobectomy and VATS segmentectomy for patients with NSCLC <2 cm.
Share pledging and financial constraints in China
Authors: Cheng Zijian , Liu Zhangxin (Frank) , Sun Yupu 
Published: December 2020

AbstractWe investigate the relationship between the intensity of share pledging activities and the level of financial constraint in publicly listed firms in China. We show that the high financial constraint level may motivate insiders to use share pledging as an alternative funding source and an expropriation mechanism. Although overall share collateralisation can cause a subsequently more constrained financing condition, we find evidence that share pledging made by the controlling shareholder is likely to mitigate financial constraints in the following year. Our findings are robust to alternative measures and an instrumental variable for dealing with endogeneity problems.
Unraveling molecular mechanisms involved in the development of leptin resistance using the pig as a model
Authors: Mármol‐Sánchez E. , Artman J. S. , Fredholm M. , Cirera S. 
Published: December 2020

SummaryThe increase in obesity worldwide underlines the need for research concerning its metabolic and genetic determinants. One of the most intriguing mechanisms regarding obesity involves leptin and its signaling cascade. Leptin is a key regulator contributing to the fine‐tuned crosstalk between nutrient availability and appetite signaling in the central nervous system. Owing to ethical concerns, many human tissues are not readily available and pigs can serve as a good animal model owing to their comparable anatomy, metabolism and genetics. In the present study, we utilized the pig to investigate the possible impact of increased adiposity on the development of alterations within the leptin signaling pathway. Two divergent groups of pigs (High and Low) were defined based on a high and low amount of mesenteric fat. Cortex, cerebellum, hypothalamus, mesenteric, subcutaneous and retroperitoneal fat tissues were used to study changes in expression levels of 94 mRNA transcripts related to the leptin signaling pathway using the qPCR approach. No significant differences were found at the central nervous system, whereas the expression level of STAT1 was reduced in mesenteric fat and leptin (LEP) and interleukin 6 (IL6) were shown to be consistently increased in all analyzed fat compartments from pigs with a high amount of mesenteric fat. These results could imply the onset of leptin and pro‐inflammatory cytokine overexpression at early stages of obesity in the analyzed pigs without affecting any key components in the central nervous system. Thus, these pigs showing a unique leptin deregulation in adipose tissues could be a useful translational resource for studies of obesity and leptin resistance phenotypes.
Investigating the interaction between nifedipine‐ and ritonavir‐containing antiviral regimens: A physiologically based pharmacokinetic/pharmacodynamic analysis
Authors: Niu Wanjie , Li Size , Jin Shasha , Lin Xiying , Zhang Mengwan , Cai Weimin , Jiao Zheng , Xiang Xiaoqiang 
Published: December 2020

AimsHypertension is a common comorbidity of patients with COVID‐19, SARS or HIV infection. Such patients are often concomitantly treated with antiviral and antihypertensive agents, including ritonavir and nifedipine. Since ritonavir is a strong inhibitor of CYP3A and nifedipine is mainly metabolized via CYP3A, the combination of ritonavir and nifedipine can potentially cause drug–drug interactions. This study provides guidance on nifedipine treatment during and after coadministration with ritonavir‐containing regimens, using a physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) analysis.MethodsThe PBPK/PD models for 3 formations of nifedipine were developed based on the Simcyp nifedipine model and the models were verified using published data. The effects of ritonavir on nifedipine exposure and systolic blood pressure (SBP) were assessed for instant‐release, sustained‐release and controlled‐release formulations in patients. Various nifedipine regimens were investigated when coadministered with or without ritonavir.ResultsPBPK/PD models for 3 formulations of nifedipine were successfully established. The predicted maximum concentration (Cmax), area under plasma concentration–time curve (AUC), maximum reduction in SBP and area under effect–time curve were all within 0.5–2.0‐fold of the observed data. Model simulations showed that the inhibitory effect of ritonavir on CYP3A4 increased the Cmax of nifedipine 17.92–48.85‐fold and the AUC 63.30–84.01‐fold at steady state and decreased the SBP by >40 mmHg. Thus, the combination of nifedipine and ritonavir could lead to severe hypotension.ConclusionRitonavir significantly affects the pharmacokinetics and antihypertensive effect of nifedipine. It is not recommended for patients to take nifedipine‐ and ritonavir‐containing regimens simultaneously.
Trends in polypharmacy and potentially inappropriate medication (PIM) in older and middle‐aged people treated for diabetes
Authors: Oktora Monika Pury , Alfian Sofa Dewi , Bos H. Jens , Schuiling‐Veninga Catharina Carolina Maria , Taxis Katja , Hak Eelko , Denig Petra 
Published: December 2020

AimsPolypharmacy is common in people with diabetes and is associated with the use of potentially inappropriate medication (PIM). This study aimed to assess trends in the prevalence of polypharmacy and PIM in older and middle‐aged people with diabetes.MethodsA repeated cross‐sectional study using the University Groningen IADB.nl prescription database was conducted. All people aged 45 years and over who were treated for diabetes registered in the period 2012–2016 were included. Polypharmacy was assessed for three age groups. PIMs were assessed using Beers criteria for people ≥65 years old, and PRescribing Optimally in Middle‐aged People's Treatments (PROMPT) criteria for 45–64 years old. Chi‐square tests and regression analysis were applied.ResultsThe prevalence of polypharmacy increased significantly in all age groups in the study period. In 2016, the prevalence of polypharmacy was 36.9% in patients aged 45–54 years, 50.3% in those aged 55–64 years, and 66.2% in those aged ≥65 years. The prevalence of older people with at least one PIM decreased by 3.1%, while in the middle‐aged group this prevalence increased by 0.9% from 2012 to 2016. The most common PIMs in both age groups were the use of long‐term high‐dose proton pump inhibitors, benzodiazepines and strong opioids without laxatives. Of those, only benzodiazepines showed a decreasing trend.ConclusionsPolypharmacy increased in older and middle‐aged people with diabetes. While the prevalence of PIM decreased over time in older age, this trend was not observed in middle‐aged people with diabetes. Efforts are needed to decrease the use of PIMs in populations already burdened with many drugs, notably at middle age.
HoloLens and mobile augmented reality in medical and health science education: A randomised controlled trial
Authors: Moro Christian , Phelps Charlotte , Redmond Petrea , Stromberga Zane 
Published: December 2020

AbstractDue to increasing demands in the amount of content to be learned within a medical and health sciences curriculum, there are benefits towards exploring options for new and effective delivery modes. Augmented reality technology has the potential to enhance learning in physiology and anatomy, where students require a three‐dimensional knowledge of human organ systems and structures. This study aimed to assess the effectiveness of learning when an identical lesson was delivered through augmented reality using either the Microsoft HoloLens or a mobile handheld tablet device. Thirty‐eight pre‐clinical undergraduate participants completed a lesson detailing the physiology and anatomy of the brain. Pre‐ and post‐intervention tests were provided to evaluate acquired knowledge. After the activity, participants also completed a Likert‐style questionnaire to evaluate adverse health effects experienced and assess their perceptions of the module. There were no significant differences between test scores from lesson delivery in either the HoloLens or mobile‐based augmented reality. However, a significant increase was reported in dizziness when using the HoloLens (25% higher, n = 19, p = .04). No other adverse health effects, such as nausea, disorientation or fatigue were observed. Both modes were effective for learning, providing evidence to support educators and developers wishing to adopt an augmented reality method of delivery in health sciences and medicine.A video abstract of this article can be viewed at https://youtu.be/GSayCmopGZg
Practitioner NotesWhat is already known about this topic

Modern technology continues to disrupt the way we teach in higher education.
Teaching through virtual and augmented reality has shown great benefit in enhancing learning and the student experience in health sciences and medicine.
There is the potential for new and upcoming delivery modes to continue this trend, including the introduction of both mobile and head‐mounted display based augmented reality.
What this study contributes

Investigates the potential for augmented reality to be used as a teaching tool, and supports its implementation in tertiary education.
Identifies that although slight dizziness was reported in some participants from using the HoloLens, this does not appear to impact learning or student perceptions of the technology.
Presents the HoloLens and mobile‐based augmented reality as novel and evidence‐based methods of instruction in health sciences and medicine.
Implications for practice and/or policy

Augmented reality is an effective delivery mode which can enhance learning.
Students consider augmented reality through both the HoloLens and mobile‐based devices to be enjoyable and engaging.
This novel method of instruction is useful to supplement learning in a tertiary education programme.
Improving parenting knowledge through caregiver education in China
Authors: Chen Yafan , Tu Bin , Huang Chien‐Chung , Huang Can 
Published: December 2020

AbstractBackgroundCaregivers' parenting knowledge is of importance to child development and to achieve positive child outcomes. Even though some caregiver education programs have demonstrated positive effects, most of them are carried out in developed countries and among western samples. As a developing country with the second‐largest child population worldwide, China has initiated caregiver education programs to promote parenting knowledge among caregivers since 2016. This study examines the effect of an innovative caregiver education program on caregivers' perceived increase of parenting knowledge.MethodsA total of 310 caregivers with a child aged between 0 and 3 from Z city, China, were randomly selected to complete a survey. Caregivers' perceived increase of parenting knowledge was assessed by five specified knowledge dimensions, namely, child growth, feeding behaviours, daily care, disease prevention and safety. The independent variable was program participation, measured by respondents' use of program services. OLS regression was employed to assess the association between caregivers' program participation and their perceived increase of knowledge, controlling basic demographic and socio‐economic factors.ResultsIn general, program participation had statistically significant associations with caregivers' perceived increase of parenting knowledge. The associations varied by service type. Particularly, online development evaluations and in‐home sessions showed relatively consistent and positive effects on caregivers' perceived increase of parenting knowledge.ConclusionsThis caregiver education program had a positive effect on caregivers' perceived increase of parenting knowledge, particularly through the use of the online development evaluations and in‐home sessions. As one of the earliest initiatives of this kind in China, the findings reveal the promise of an innovative program to advance caregivers and children.