bluuebunny/crossref_metadata_2025_split huggingface dataset:
CONCEPT "DESTINY" IN CHINESE AND KAZAKH LINGUOCULTURES
Authors: Daulet Fatimabibi , Orazakynkyzy Farida , Saule Anuar , Zeinolla Zhanat , Gulnaz Zhunisbek , Karapetiants Artemii 
Published: December 2019

Purpose of the study: The study examines the language specificity of the concept "destiny" as an important marker of the national mental space of Chinese and Kazakh ethnocultures. The authors revealed the national specifics of this concept, analyzed its historical and philosophical features of development in Chinese and Kazakh linguocultures, and also established its most important conceptual, value and figurative characteristics.
Methodology: This research was based on a number of lexicon-semantic and structural-grammatical methods of analysis. In addition, the authors used component analysis of the meaning of language units, methods of synchronous, comparative and comparative analysis, as well as structural-typological, comparative-historical, historical-etymological methods.
Main findings: The authors presented the evaluation of linguistic-philosophical aspects of the concept “destiny”, ways of its representation in various concept spheres, as well as patterns of its functioning in various discourses. In addition, this concept belongs to the category of axiological concepts and is regarded as a marker of the national mental space. It has a cultural dimension and is able to determine the specificity of the national concept sphere.
Applications of this study: The results of this work can be used in further studying the concept of "destiny" in both related and genetically distant languages, in various types of discourse. A promising is a separate consideration of the phraseological and paremiological embodiment of the studied concept, as well as its connection with other concepts, such as “life”, “death”, “happiness”, “love”, “soul”, “path”, etc. It is also worth to note the are practical significance of the study of the translation aspect of the concept "destiny".
Implications of the study: The authors believe that the results of the study will help to better understand the native Chinese speakers. This can help increase the effectiveness of intercultural communication, which is immeasurably important in living conditions in the “global village”, as well as respect for one’s culture and understanding of someone else’s.
Novelty/Originality of this study: The significance of the study is due to the fact that, according to our data, a systematic comparative description of the universal and cultural-specific characteristics of the concept “destiny” in Chinese and Kazakh linguocultures has not yet been carried out. The theoretical significance of the study lies in the development and refinement of the scientific understanding of the characteristics of the concept, the definition of specific discreteness, which the concept “destiny” implements in Chinese and Kazakh languages.
ONTOLOGICAL AND SOCIO-CULTURAL FOUNDATIONS OF THE INTER-GENERATED DISCOURSE IN THE MODERN INFORMATION SOCIETY
Authors: N. Ivanenko I. , M. Nikitin G. , A. Mokhovaya T. 
Published: December 2019

Purpose of the study: The article is devoted to understanding the problems of intergenerational discourse and its transformation in ontological and sociocultural reality. The paper substantiates the need to maintain the mechanism of accumulation and reproduction of the experience of ancestors. It is shown that the violation of the transfer of knowledge and traditions leads to the distortion or disappearance of universal cultural codes.
Methodology: In this article, cultural, demographic, and psychological approaches are used to study the ontological and sociocultural foundations of intergenerational discourse. It is necessary to show the influence of historical and socio-cultural transformations on the characteristics of interaction between generations, to determine the form of transfer and assimilation of experience within the family, to demonstrate the socially significant consequences of the demographic revolution in the modern information society.
Main Findings: Having outlined only a few reasons for the intergenerational discourse in the field of translation of sociocultural experience, it can be noted that their combination forms the layer of human life in which historically determined values and ideals of human society are realized, methods of accumulation and transfer of experience that are unique for each historical era, new methods communications.
Applications of this study: Research results can be applied in the course of social psychology (today, young people are literally imposed a radical cultural gap with previous generations), social philosophy, cultural studies (the form of transfer of experience within the family) and even demography (large-scale changes in human society, with the destruction of human social instincts).
Novelty/Originality of this study: As the initial task of the study, it is supposed to identify historical and sociocultural changes in the field of translation and appropriation of experience, to conduct a cultural analysis that gives a clear idea of the evolution of the methods of interaction between generations. An interdisciplinary approach involves a wider coverage of existing concepts and shows that the patterns of development of human society cannot be reduced only to biological, economic or socio-cultural patterns.
A CASE STUDY OF THE HEALTH STATUS OF THE THREE DISTRICTS OF ANDAMAN AND NICOBAR ISLANDS A UNION TERRITORY OF INDIA
Authors: Begum Salma 
Published: December 2019

The objective of the study: To assess the burden of disease on the tribal and non-tribal population of Andaman and Nicobar Islands.
Methodology: The study focuses on the health status of the tribal and non-tribal population of the Islands and measures theirs out of pocket expenditure on health for 12 months in the year 2016. Primary data has been collected to conduct the study from all three districts of the islands using a random sampling method, and the same has been analyzed using a descriptive-analytical technique and multiple regression models.
Results: Standard multiple regression analysis provides a significant result. The result shows as Annual income increase, the out of pocket expenditure will increase by 0.727 rupees. When the age of the people increases, out of pocket expenditure will increase at a rate of 0.782, and as the quality of public health care services improves out of pocket expenditure will increase to 0.533, which is lower than the other two variables. The annual income age and quality of public health care all have a statistically significant impact on the outcome variable or out of pocket expenditure as the p-value is less than 0.05; therefore, the model is a good fit.
Conclusion: Most households in all three districts do not have proper toilet facility and latrine, which lead them to suffer communicable disease such as diarrhea. Also, the majority of them do not treat drinking water, which again causes their illness. The scattered and isolated location of the Andaman and Nicobar Islands and non-availability of the specialist doctors, surgeons, and well equipped curative health centers or hospitals are the crucial reasons for the huge out of pocket expenditure incurred by the islanders while taking treatment at the mainland.
Implication: This study provides insights on the health status of the tribal and non-tribal population of Andaman and Nicobar Islands. It will be helpful to develop better policies for improving the current healthcare scenario.
Originality and Novelty of the study: There was no earlier study done on the tribal of Andaman and Nicobar Islands.
AN EXAMINATION OF SISTERHOOD AS AN EMANCIPATIVE CONCEPT IN ALICE WALKER'S NOVELS: MERIDIAN AND THE COLOR PURPLE
Authors: Ahmadgoli Kamran , Faroug Raoof Liath 
Published: December 2019

Purpose of the study: The study aims to examine the concept of sisterhood as an emancipative endeavor to empower and free the Afro-American women in Alice Walker's (1942) novels: Meridian and the Color Purple, through the liberal treatment of Black Feminism. Methodology: Qualitative research aims to form speculations or facts that are derived from secondary sources. It tries to understand Walker's liberal treatment of sisterhood, in the selected novels, through the radical black feminism, and the feminist liberal lens of bell hooks. The study considered other related critics and scholars to help further illuminate the emancipative notion of sisterhood. The study is a library-based drawn on literary and critical books and articles. Main finding: The study clarifies the emancipative notion of hooks on Walker's feminist attitude of sisterhood in the selected novels as a privilege to enhance black women's growth and to strengthen the social bond to achieve women's liberation. Simultaneously, the study criticizes the Western oppressive authority as well as the traditional one-sided thinking of mainstream feminism. By a new and liberal reading of hooks' perspective, the study illuminates that the collective power and mass struggle of Afro-American women lead to self-realization and identity. Implication: This study can be used by scholars and activists to understand how Afro-American women have been undergoing a long process of transformation by radical feminist thinking, from exploitation, domination, and oppression toward the center of social, political and cultural focus. Originality/Novelty: A new reading of Walker's novels is utilized by the light of bell hooks' emancipative notion of sisterhood.
Prevention of the adverse effects of androgen deprivation therapy for prostate cancer using a 12-month home-based progressive resistance training program: a randomised controlled study
Authors: Lam Teresa , Cheema Birinder , Hayden Amy , Lord Stephen R. , Gurney Howard , Gounden Shivanjini , Reddy Navneeta , Shahidipour Haleh , Read Scott , Stone Glenn , McLean Mark , Birzniece Vita 
Published: December 2019

Abstract
Background In men with prostate cancer, androgen deprivation therapy (ADT) has detrimental effects on body composition and quality of life (QOL), which can be ameliorated with exercise interventions including progressive resistance training (PRT). Existing studies focus on reversing established changes using supervised programs. We investigated whether a home-based PRT program, instituted at the start of ADT, could prevent adverse effects over 12-months.Methods Twenty-five patients scheduled to receive at least 12 months of ADT were assigned to either usual care (UC) (n=12) or PRT (n=13) starting after their first ADT injection. Body composition, body cell mass (BCM; a functional component of lean body mass), insulin sensitivity, QOL and muscle function were measured at 6 weeks, 6- and 12 months. Data were analysed by a linear mixed model.Results Across the cohort, ADT had a negative impact on body composition, muscle strength, glucose metabolism and QOL. Compared to PRT patients at 12 months, UC patients had greater reductions in BCM by -1.9 ± 0.8% (p = 0.02) and higher gains in fat mass by 3.1 ± 1.0% (p = 0.002). There was a significant increase in physical activity levels (p = 0.02), and QOL in the mental health (p = 0.01) and vitality (p = 0.02) domains in the PRT compared to the UC group.Conclusion A home-based PRT program instituted at the start of ADT counteracts detrimental changes in body composition, improves physical activity and mental health over 12 months.
Investigation of the association between family members’ satisfaction with patient care in the Intensive Care Unit, spirituality and resilience.
Authors: Papathanasiou Iokasti , Tzenetidis Vasileios , Nikolentzos Athanasios , Sarafis Pavlos , Malliarou Maria 
Published: December 2019

Abstract
Background: The admission of a patient in the Intensive Care Unit (ICU) is a traumatic experience for the patient himself and his support group which mainly consists of his family members. The psychological burden of the family members increases, as they experience negative feelings. The implementation of family-centered care helps family members to satisfy their needs, eliminates psychological impact and improves patient’s health outcomes. The aim of this study is to investigate the family members’ satisfaction with patient care in the ICU, their perceived stress, spirituality and resilience.Methods: One hundred and four family members of patients admitted in the ICU for greater than 48 hours between January and March 2019 were enrolled. The questionnaire included the following psychometric tools: the Family Satisfaction with care in the Intensive Care Unit scale, the Perceived Stress Scale, the Connor – Davidson Resilience Scale, the Daily Spiritual Experience Scale and the Acute Physiology and Chronic Health Evaluation Scale. Results: The mean value of satisfaction with care was 88,9%, of satisfaction with decision making was 79,1% and of the overall satisfaction was 85%. Resilience was associated with perceived stress (p<0,001) and with spirituality (p= 0,019). Spirituality was associated with satisfaction with care (p= 0.013), with satisfaction with decision making (p= 0,018) and with the overall satisfaction (p= 0,003).Conclusions: Family members were highly satisfied. Those with higher spirituality score were more satisfied and those who were more resilient had less perceived stress. These data suggest that interventions should aim at increasing resilience and providing spiritual assistance to family members of ICU treated patients.
Integration of proteome and transcriptome refines key molecular processes underlying oil production in Nannochloropsis oceanica
Authors: You Wuxin , Wei Li , Gong Yanhai , Hajjami Mohamed El , Xu Jian , Poetsch Ansgar 
Published: December 2019

Abstract
Background Under nitrogen deficiency situation, Nannochloropsis spp. accumulate large amounts of lipid in the form of triacylglycerides (TAG). Several researches have studied the mechanism of this process from the perspective of transcriptome and metabolome, yet proteome analysis on this process is still sparse and lacking the analysis of the dynamic adaption to nitrogen deficiency. Here, proteomes for 03h, 06h, 12h, 24h, 48h and 10th day of nitrogen deplete and replete conditions were compared. New proteome results were integrated with existing transcriptome and other data.Results Obtained results illuminated physiological adaptations not deduced from previous transcriptome data: (a) Abundance of proteins related to photosynthesis only slightly decreased in the first 48h, indicating that photosynthesis is still working efficiently, and protein amounts adjust gradually with reduction in chloroplast size. (b) Most proteins related to the TCA cycle were strongly upregulated after 48h under nitrogen deficiency, suggesting that respiration is enhanced after 48h and that TCA cycle efflux supports the carbon required for lipid synthesis. (c) Proteins related to lipid accumulation via the Kennedy pathway increased their abundance at 48h, synchronous with the previously reported diversification of fatty acids after 48h.Conclusions This study adds a proteome perspective on the major pathways for TAG accumulation by Nannochloropsis due to absence of nitrogen: photosynthesis, membrane lipid conversion, protein degradation, TCA cycle. By integrating existing transcriptome and other data, our research provided for Nannochloropsis oceanica a multi-layered description of adaptation to nitrogen limitation and lipid accumulation. Cluster analysis of this integrated dataset allowed inference of post-transcriptional regulation events.
Optimisation of a fuzzy logic-based local real-time control system for mitigation of sewer flooding using genetic algorithms
Authors: Mounce S. R. , Shepherd W. , Ostojin S. , Abdel-Aal M. , Schellart A. N. A. , Shucksmith J. D. , Tait S. J. 
Published: December 2019

Abstract
Urban flooding damages properties, causes economic losses and can seriously threaten public health. An innovative, fuzzy logic (FL)-based, local autonomous real-time control (RTC) approach for mitigating this hazard utilising the existing spare capacity in urban drainage networks has been developed. The default parameters for the control algorithm, which uses water level-based data, were derived based on domain expert knowledge and optimised by linking the control algorithm programmatically to a hydrodynamic sewer network model. This paper describes a novel genetic algorithm (GA) optimisation of the FL membership functions (MFs) for the developed control algorithm. In order to provide the GA with strong training and test scenarios, the compiled rainfall time series based on recorded rainfall and incorporating multiple events were used in the optimisation. Both decimal and integer GA optimisations were carried out. The integer optimisation was shown to perform better on unseen events than the decimal version with considerably reduced computational run time. The optimised FL MFs result in an average 25% decrease in the flood volume compared to those selected by experts for unseen rainfall events. This distributed, autonomous control using GA optimisation offers significant benefits over traditional RTC approaches for flood risk management.
Deriving optimal operation of reservoir proposing improved artificial bee colony algorithm: standard and constrained versions
Authors: Soghrati F. , Moeini R. 
Published: December 2019

Abstract
In this paper, one of the newest meta-heuristic algorithms, named artificial bee colony (ABC) algorithm, is used to solve the single-reservoir operation optimization problem. The simple and hydropower reservoir operation optimization problems of Dez reservoir, in southern Iran, have been solved here over 60, 240, and 480 monthly operation time periods considering two different decision variables. In addition, to improve the performance of this algorithm, two improved artificial bee colony algorithms have been proposed and these problems have been solved using them. Furthermore, in order to improve the performance of proposed algorithms to solve large-scale problems, two constrained versions of these algorithms have been proposed, in which in these algorithms the problem constraints have been explicitly satisfied. Comparison of the results shows that using the proposed algorithm leads to better results with low computational costs in comparison with other available methods such as genetic algorithm (GA), standard and improved particle swarm optimization (IPSO) algorithm, honey-bees mating optimization (HBMO) algorithm, ant colony optimization algorithm (ACOA), and gravitational search algorithm (GSA). Therefore, the proposed algorithms are capable algorithms to solve large reservoir operation optimization problems.
Preclinical Pharmacokinetics Study of a Novel Intravenous Anesthetic ET-26 Hydrochloride
Authors: Zhang Yu Jun , Deng ChaoYi , Yang Jun , Gong DeYing , Kang Yi , Liu Jin , Zhang WenSheng 
Published: December 2019

Background:
ET-26 hydrochloride is a novel intravenous anesthetic, approved for clinical trials, that
produces a desirable sedative-hypnotic effect with stable myocardial performance and mild adrenocortical suppression
in rats and beagle dogs. The objective of this study was to assess the absorption, distribution, metabolism, and
excretion of ET-26 hydrochloride.

Methods:
Hepatocytes from human, monkey, dog, rat, and mouse were used to determine the metabolites of ET-26
hydrochloride. Distribution and excretion were assessed in rats and pharmacokinetic studies were performed in beagle
dogs.

Results:
The metabolic pathway and proposed structure of metabolites were fully assessed resulting from the
biotransformation reactions of hydrolysis, dehydrogenation, demethylation and glucuronic acid conjugation. The
main distribution of the drug was in fat (15067 ± 801 ng/ml) and liver (13647 ± 1126 ng/ml), and the kidney was the
primary excretion route (4.47%-11.94%). The Cmax after injection with 1.045 mg/kg, 2.09 mg/kg, and 4.18 mg/kg
was 1476.5 ± 138.9 ng/ml, 2846.1 ± 223.3 ng/ml, and 6233.3 ± 238.9 ng/ml, respectively. The t1/2 of the drug was
similar across dose groups at 74.8 ± 10.8 min to 81.4 ± 4.2 min. The AUC0-t values were 30208.1 ± 2026.5
min*ng/ml, 62712.8 ± 1808.3 min*ng/ml, and 130465.2 ± 7457.4 min*ng/ml, respectively.

Conclusion:
The metabolic pathway and the proposed structure of metabolites for ET-26 hydrochloride were fully
assessed. The majority of distribution for ET-26 hydrochloride occurs in the fat and liver, while the primary route of
excretion for ET-26 hydrochloride is through the kidney. In dogs, pharmacokinetic features of ET-26 hydrochloride
had a linear relationship with dosage.
FBXW7alpha Promotes the Recovery of Traumatic Spinal Cord
Authors: Zhang Hong , Yang Tao 
Published: December 2019

Background:White matter damage and neuronal cell death are incurred by spinal cord injury (SCI). FBXW7α, an important mediator of cell division and growth was investigated to explore its role in repairing the traumatic spinal cord in rats. Underlying mechanisms such as oxidative stress and inflammasomes signaling were also studied.Methods:Spinal cord injury in rats was established by longitudinal surgical incision from the lower to mid-thoracic vertebrae on the backside, followed by 20-g weight placed on the exposed Th12 surface for 30 min. AAV-delivered FBXW7α and -sh-FBXW7α were intrathecally injected into the rat spinal cord. Indices of oxidation, neurotrophic factors, and pyroptosis were measured by Western blot, Elisa, and RT-PCR.Results:We found the overexpression of FBXW7α in spinal cord rescue neuronal death triggered by the injury. Specifically, the nutritional condition, oxidative stress, and pyroptosis were improved. A synchronization of BNDF and GDNF expression patterns in various groups indicated the secretion of neurotrophic factors affect the outcome of SCI. The SOD1, CAT, and GSH-px were suppressed after trauma but all restored in response to FBXW7α overexpression. Inflammasomes-activated pyroptosis was incurred after the injury, and relevant biomarkers such as GSDMD, caspase-1, caspase- 11, IL-1β, and IL-18 were down-regulated after the introduction of FBXW7α into the injured cord. Additionally, up-regulating FBXW7α also repaired the mitochondria dysfunction.Conclusion:Our data indicate FBXW7α probably serves as an important molecular target for the therapy of spinal cord injury.