bluuebunny/crossref_metadata_2025_split huggingface dataset:
Memory-enhancing effects of goat milk in D-galactose-induced aging rat model
Authors: Safdar Afifa , Azman Khairunnuur Fairuz , Zakaria Rahimah , Ab Aziz Che Badariah , Rashid Usman 
Published: January 2020

Introduction: Aging is a physiological process accompanied by cognitive decline, particularly in memory deterioration. D-galactose is a reducing monosaccharide which, if systemically exposed, causes accelerated senescence in several organs and is widely being used as an ideal agent to induce brain aging in animal models. Goat milk is a food of high nutritional value which has been demonstrated to possess strong antioxidant and anti-inflammatory properties. However, thus far, little is known of its possible effects on the brain, especially on memory during aging. The present study examined the efficiency of goat milk supplementation on memory performance in a D-galactose induced aging rat model.
Methods: Fifty-two male Sprague Dawley rats were randomly divided into four groups: 1) control group, 2) goat milk treated group, 3) D-galactose treated group, and 4) goat milk plus D-galactose treated group. D-galactose (120 mg/kg subcutaneously) and/or goat milk (1 g/kg orally) were administered continuously for six weeks, preceded and followed by novel object recognition and T-maze tests.
Results: Prior to goat milk and D-galactose administration, there was no significant difference (p>0.05) in memory performance among all groups. Six weeks of D-galactose administration significantly decreased (p<0.001) short-term, long-term and spatial memory performance. Goat milk supplementation in the D-galactose induced rats managed to protect against memory decline, as exhibited by significantly higher (p<0.0001) short-term, long-term and spatial memory performance of the D-galactose plus goat milk treated group, compared to the D-galactose treated group.
Conclusion: In conclusion, goat milk possesses memoryenhancing effects and, hence. may be useful in protecting against age-related memory deficits.
A fizikai aktivitás hatásai az időskori kognitív működésre
Authors: Mile Marianna , Tatai Csilla , Fábián Balázs , Csiki Zoltán 
Published: January 2020

Absztrakt:
Az időskorú személyek száma és társadalmi aránya folyamatosan növekszik, különös
tekintettel az európai országokra, de ez a világ teljes népességére is
vonatkozik. Az idősebb korosztály arányának további gyarapodásával az öregedő
társadalom egészségi állapotának romlása okozta szociális és egészségügyi
szférákat érintő többletköltségek is egyre tovább emelkednek. Az öregedés
folyamata az egészségi állapot romlásának és az általános funkcióképesség
csökkenésének testi vonatkozásain túl a mentális, kognitív teljesítmény
romlásával is együtt jár, ami tovább nehezíti az idős korosztály mindennapjait.
Ezek a tények felhívják a figyelmet a beavatkozás megjósolható szükségességére.
A korábbi vizsgálati eredmények szerint a fizikai aktivitás alkalmas lehet a
kognitív működés javítására, a romlás megállítására és megelőzésére. A jelen
közleményben áttekintjük a fizikai aktivitásnak a kognitív működésre kifejtett
hatásait mind általánosságban, mind pedig három specifikus mozgásforma
tekintetében, illetve a további aktuális kutatási irányokat is felvázoljuk. Orv
Hetil. 2020; 161(5): 163–168.
Extrém hosszú tartamú 1-es típusú diabetes mellitus ritka esete
Authors: Fövényi József 
Published: January 2020

Absztrakt:
Az 1-es típusú diabetes mortalitása, bár csökkenő tendenciát mutatva, jelentősen
meghaladja a standard mortalitást. Ez egyúttal a diabetesszel megélt életévek
rövidülésével jár együtt. Az esetismertetés tárgya egy 86 éves diabetestartammal
a 91. életévét megélő nőbeteg, akit több mint 55 éven keresztül egyetlen orvos –
a szerző – kezelt/gondozott. Az 1932-ben, ötéves korában fellépett diabetest
először naponta háromszor adagolt gyors hatású inzulinnal, majd 1940-től kezdve
naponta egyszer alkalmazott gyors hatású és cink-protamin inzulinnal, később
sertés, majd humán kristályos cinkinzulinnal, majd az utolsó 16 évben gyors
hatású NPH-inzulin keverékével kezelték. Ennek oka az volt, hogy a beteg
rögeszmésen ragaszkodott a napi egyszeri inzulinadáshoz, és hogy esetében
mindegyik inzulin hatástartama 24 órásnak bizonyult. Az évtizedeken át
folyamatosan túladagolt egyszeri inzulinadás következménye a szinte naponta,
főként az éjjeli órákban fellépő hypoglykaemia lett, következményes nagyfokú
vércukor-ingadozásokkal. Az 1930-as évek közepétől a hatvanas évekig
polarimetriás, majd száraz kémiás módszerrel vizeletcukor-önellenőrzést végzett
a nyolcvanas évek elejéig, majd áttért a vércukor-önellenőrzésre. Az ötvenes
években két sikertelen terhessége volt, 2010–11-ben egymás után jobb, majd bal
oldali combnyaktörést szenvedett, majd mindkét szemén megműtötték a
cataractáját. Az utolsó 25 évben HbA1c-szintje 7% körül mozgott. Sem
retinopathia, sem nephropathia nem fejlődött ki nála, csupán súlyos neuropathia
okozott panaszokat az utolsó években. Emellett időskori száraz
maculadegeneratiója miatt látása folyamatosan romlott. Elnyerte a ’Joslin 75’
medált is. Élete utolsó két hónapjában engedte, hogy degludek + glulizin
inzulinnal intenzíven kezeljék. Halálát myocardialis infarctus okozta. Bár a
vércukor-ingadozások minimalizálása és a tartósan jó anyagcsere-vezetés
jelentősen javítja a diabetesesek életkilátásait, esetünkben jó fél évszázadon
keresztül egyik sem állt fenn. Ezért az extrém hosszú diabetestartamra nem
találtunk magyarázatot. Orv Hetil. 2020; 161(5): 193–197.
Improving Farm Management Information Systems with Data Mining
Authors: CATAL Cagatay , KASSAHUN Ayalew , HOVİNG Henk Jan 
Published: January 2020

Over the past several
years, farm enterprises have grown in size substantially while their number has
steadily declined. As the size of their farms grow more and more farmers are
deploying information systems, commonly called as Farm Management Information
Systems (FMIS), to manage the day to day activities of their farms. The
deployment of FMIS enable farmers to capture detailed data that can potentially
be analysed by data mining tools to provide valuable information for optimizing
the farm enterprises. However, data mining is generally not a common feature of
many FMIS. In order to evaluate the suitability of data mining for use in FMIS,
we performed two case studies using data captured in FMIS and applying data
mining. Microsoft Azure Machine Learning Studio is chosen because it provides a
simple drag-and-drop visual interface that can be used by farm domain experts.
We addressed two common problems in dairy farming: calving prediction of dairy
cows and prediction of lactation value of milking cows. In both cases we built
data mining models and run experiments and our results in both cases indicate
that the required data is available from FMIS and data mining techniques provides
acceptable performance. We also showed that farm domain experts can easily use
a user-friendly and drag-and-drop data mining tools with minimal initial
training. Based on the insight from the two case studies and literature study, we
identified several decision problems that can be addressed with data mining such
as heat prediction and lameness prediction.
Remodeling of the heart and main vessels in patients with marfanoid habitus
Authors: Timofeev Eugene V. , Malev Eduard G. , Parfenova Nina N. , Zemtsovsky Eduard V. 
Published: January 2020

For many hereditary connective tissue disorders (HCTD), especially Marfan syndrome, remodeling of the heart and main vessels is described, which is manifested by a decrease in the systolic function of the left ventricle and expansion of the thoracic aorta. Evaluation of morphometric characteristics of the heart and main vessels in patients with other HCTD, in particular marfanoid habitus (MH) has not been previously carried out.
Materials and methods. Weexamined 90 young men and 74 young women between the ages of 18 to 25 years, 111 patients older age groups with stable over coronary heart disease (mean age 64.66.2 years) and 9 patients with verified Marfan syndrome (mean age 27.99.3years). All survey phenotypic and performed anthropometric survey identifying bone signs of dysembryogenesis as well as Echocardiography study on standard protocol.
The results.Patients with MH as compared with control group revealed a relatively larger diameter of aortic root (30.44.7 vs 28.03.6 mm,p= 0.03) and the ascending aorta (26.64.9 vs 24.63.2 mm,p= 0.05). Also young with MH turned out to be significantly thicker myocardium of left ventricular posterior wall (8.30.8 vs 7.71.1 mm,p= 0.02) and interventricular septum (8.81.2vs 8.21.1mm,p= 0.04). When performing correlation analysis identified reliable positive correlation between such highly specialized bone signs as high palate (r= 0.31), infundibular deformation of the chest (r= 0.43), arachnodactyly (r= 0.45) andZ-test (p 0.05 for all). Expansion of the aorta (Z-criterion 2.0) have found 24% of older patients with MH.
Conclusion.Inpatients with MH revealed significant structural changes of heart and main vessels which are progredient character thickening of the left ventricular myocardium and expansion of the aortic root.
Gastrointestinal risk factors for anemia in children with celiac disease
Authors: Shapovalova Natalia S. , Novikova Valeriya P. , Revnova Maria O. , Gurina Olga P. , Dementieva Elena A. , Klikunova Ksenia A. 
Published: January 2020

With oral intake, iron absorption in patients with celiac disease (CD) is reduced due to the decreased absorption surface of the atrophic small intestine mucous membrane. Besides, there are additional risk factors for anemia whose mechanisms are unclear.The aimof this study was to evaluate gastrointestinal risk factors for anemia in children.
Materialsand methods.The first group consisted of 58 children with newly diagnosed CD who did not adhere to the gluten-free diet(GFD). The second group included 49 children with CD who hasnt been adhering to the GFD. The third group included 69children with chronic gastritis (CG) without CD. In addition to the standard examination, which includes the determination of antibodies to tissue transglutaminase and histological examination of the duodenum mucous membrane, a histological evaluation of the gastric mucosa, determination of pepsinogen 1 and 2 and their ratio, antibodies to Castles intrinsic factor were performed.
Results.The mean level of hemoglobin in the group 1114,71120,10125,50g/l, in the group 2124,37128,74133,10g/l, in the group 3130,12133,78137,43g/l (p1,2=0.013;p1,3=0,000;p2,3=0.083). A correlation analysis of the hemoglobin level and morphological parameters of the duodenal mucosa among the studied patients revealed an inverse moderate correlation between the hemoglobin level and the degree of the small intestinal atrophy according to Marshr=0.331,p=0,000, crypt depthr=0,439,p=0,000, and a moderate direct with the ratio of villi:cryptr=0.417,p=0.000, with the height of the villir=0.366,p=0,000. Additionally, a moderate direct correlation between the level of hemoglobin and the number of parietal cells was found to ber=0.354,p=0.037. In group 1, a significant inverse correlation between the level of hemoglobin and the level of antibodies to Castles factorr=0.529,p=0.006, was obtained for the level of antibodies in the Castles factor.
Conclusion.Autoimmune gastritis may be an additional risk factor in combination with malabsorption, as a possible cause of anemia in children with CD.
The Međimurje (Croatia) Earthquake of 1738
Authors: Herak Davorka , Živčić Mladen , Vrkić Iva , Herak Marijan 
Published: January 2020

Abstract
The 30 March 1738 earthquake with an epicenter near Čakovec in Međimurje (Croatia) is the largest known earthquake in the low-seismicity area that includes northernmost Croatia, northeastern Slovenia, southeastern Austria, and southwestern Hungary. So far, it has attracted very little attention in the seismological communities of those countries. It is missing or has wrong source parameters in all of the relevant earthquake catalogs (including the Seismic Hazard Harmonization in Europe (SHARE) catalog, Stucchi et al., 2013), which may influence seismic hazard assessment in this part of Europe, most critically in the Međimurje region itself. We present contemporary historical data shedding some light on the effects that the earthquake had on settlements mostly in Međimurje, but also elsewhere in Croatia, Slovenia, and Hungary. We were able to assign intensities to 12 localities surrounding the epicenter and to resolve the confusion about its date of occurrence. The intensity points were inverted for the location of the macroseismic hypocenter and epicentral intensity (I0=7.9 MSK [Medvedev–Sponheuer–Karnik]). The epicenter is found to lie on the hanging wall of the reverse Čakovec fault, about 6 km from its surface trace, and 8 km north-northwest of the town of Čakovec. The rather small felt area for an earthquake of this maximum intensity implies a shallow macroseismic focal depth of 6 km. These values of intensity and depth correspond to a macroseismic magnitude of MLm 5.1.
Effect of short-term naturopathy and yoga intervention on anthropometric variables, lipid profile and thyroid profile in obese hypothyroid patients: a randomised controlled trial
Authors: Shetty Geetha B. , Shetty Balakrishna , Shetty Prashanth 
Published: January 2020

Background: Hypothyroidism reflects decreased thyroid function and is one of the most common conditions seen in clinical practice. Practice of naturopathy and yoga has shown improvement in anthropometric variables and lipid profile in obesity and other chronic diseases. So, the aim of this study was to find out the effect of naturopathy and yoga in obese hypothyroid patients.Methods: A total of 60 subjects, of which 29 males (age 44.2±7.0 years) and 31 females (age 40.6±7.4 years) with body mass index (BMI), ≥30 were randomly assigned to case group (n=30) and wait list control group (n=30). The subjects of case group underwent naturopathy and yoga intervention for 10 days. Anthropometric variables, viz., body weight, BMI, waist circumference (WC) and hip circumference, serum lipid profile, and serum thyroid profile were assessed at 1st day (pre), at the end of 10 day (post).Results: The result showed a significant reduction in body weight, BMI, WC, total cholesterol, low density lipoprotein-cholesterol (LDL-C) and thyroid stimulating hormone (TSH) along with significant improvement in high density lipoprotein-cholesterol (HDL-C) in case group compared with control group in independent samples t test. Significant reduction in body weight, BMI, total cholesterol, LDL-C and TSH were observed in case group unlike in control group in student's paired t test.Conclusions: Reduction in the body weight, BMI and improvement in serum lipid profile and serum thyroid profile in case group subjects compared to control group suggest that naturopathy and yoga have therapeutic and protective effects in the management of obese hypothyroid patients.
Medication adherence and its determinants amongst anti-hypertensive patients in a tertiary care hospital in Navi Mumbai
Authors: Badhe Satyendra B. , Yadav Pramila V. , Deolekar Pradnya S. , Badhe Suvarna B. , Aggarwal Mihika 
Published: January 2020

Background: Anti-hypertensive drugs can effectively control hypertension, subject to good adherence. Uncontrolled hypertension can lead to numerous complications, some even potentially fatal, such as myocardial infarction, atherosclerosis, thromboembolism, shock and stroke.Methods: A cross-sectional prospective study was conducted with the help of a pre-validated questionnaire during the course of 6 months in the medicine outpatient department and the inpatient department (wards) at a tertiary care hospital, Navi Mumbai in 200 hypertensive patients to calculate the correlation of the sociodemographic factors with adherence by the chi-squared test.Results: The overall percentage of adherence to antihypertensive medication was 34.8%. It was the highest (72.1%) in the younger age group, i.e., below 50 years. It was observed that as the age increases, the adherence to treatment decreases. Adherence rates were significantly higher among females and those individuals who had never attended school. Among the employed, 70.3% were adherent to their treatment and among the unemployed, 64.4% were adherent. The percentage of adherence was lower in alcohol consumers (9.5%) as compared to nonusers (76% and 32%, respectively).Conclusions: The clinician advising anti-hypertensive therapy should provide thorough counselling and stress on the issues created due to poor medication adherence as hypertension can be associated with severe outcomes. Treatments should be given in accordance with each patient’s lifestyles in mind such that they may continue taking their medications till the completion of their therapy.
Elective induction of labour at 39 weeks versus expectant management up to 41 weeks in a tertiary care centre
Authors: Kabadi Yogindra M. , Kumar Sanjana 
Published: January 2020

Background: The timing of delivery and effective management of labour at term makes a huge difference in the obstetric and perinatal outcome. There have always been controversies between choosing the elective induction of labour at 39 weeks versus expectant management up to 41/42 weeks which can result in placental ageing, reduced liquor, non-assuring fetal heart tracings, meconium stained amniotic fluid and fetal macrosomia. our objective was to perform a comparative effectiveness analysis of elective induction of labor at 39 weeks gestational age among nulliparous women with uncomplicated singleton pregnancies as compared to expectant management up to 41 weeks.Methods: 120 primigravidae with singleton pregnancies with fetus in cephalic presentation were recruited into the study and divided into 2 groups of 60 each A: Patients were induced electively using dinoprostone gel (maximum 3 doses 8 hours apart) B: They were managed expectantly up to 41 weeks allowing for spontaneous onset of labour, induction or cesarean section was done for obstetric indications between 39 and 41 weeks and pregnancy was terminated by induction for those who continued up to 41 weeks. Their obstetric and perinatal outcome were noted.Results: The cesarean section rates were higher in the expectantly managed group (21%) when compared to the electively induced group (16%). The same was with instrumental delivery rates (15% versus 10%). The perinatal outcome was poorer for the expectantly managed group with 20% NICU admissions and 5% perinatal deaths compared to the electively induced group which had 12% NICU admissions and 3.3% perinatal deaths. The expectantly managed group also resulted in respiratory distress in a larger number of fetuses and resulted in problems due to reduced liquor.Conclusions: Elective induction at 39 weeks gestational age was found to be a better option compared to expectant management up to 41 weeks in terms of obstetric and perinatal outcomes.
Oncology patient preferences in reporting on symptoms
Authors: Peechatka Alyssa L. , Gerzon Millie , Ly Jenny J. , Dallabrida Susan M. 
Published: January 2020

<p><strong>Background:</strong> Collecting patient reported outcomes (PROs) in oncology clinical trials is becoming increasingly important. However, there is limited consensus on the most appropriate frequency of PRO administration in oncology trials. The aim of this preliminary study is to examine the perspective of participants with a cancer diagnosis on the importance of completing PROs and to identify at what frequency participants prefer to report on their cancer-related symptoms.</p><p class="abstract"><strong>Methods:</strong> 166 participants with a self-reported cancer diagnosis completed a multiple-choice online survey regarding perceptions of symptom importance and reporting preferences.</p><p class="abstract"><strong>Results:</strong> When asked about the benefit of reporting oncology-related symptoms daily, 44% of participants indicated there would be “very much” a benefit, 29% indicated there would be “quite a bit” of benefit, and 17% indicated there would be “somewhat” of a benefit. When asked about how frequently they would prefer to report symptoms, 41% of participants preferred “as they occur,” 36% preferred “once a day,” 18% preferred “once a week,” 4% preferred “twice a day,” and 1% preferred “every 4 hours”.</p><p class="abstract"><strong>Conclusions: </strong>PROs in oncology clinical research are most often collected at weekly, monthly, or longer intervals; however, meaningful fluctuations in cancer-related symptoms can occur more frequently. While concerns regarding patient burden are often raised to support infrequent reporting, these data suggest that participants would like to report symptoms with greater frequency, as episodic and daily reporting options were most popular. Based on these data, more frequent PRO data capture is not only feasible but perceived as important by individuals with cancer.</p>
Comparative evaluation of post-operative analgesic effects of intraperitoneal levobupivacaine plus fentanyl and levobupivacaine plus tramadol in patients undergoing laparoscopic cholecystectomy
Authors: Katoch Madan Lal , Kour Loveleen 
Published: January 2020

<p class="abstract"><strong>Background:</strong> Laparoscopic cholecystectomy is commonly performed as a day care procedure for treating symptomatic gallstones. Suitability of patient discharge from the inpatient facility depends upon adequacy of postoperative pain control. Among the various modalities for pain relief, intraperitoneal local anaesthetic has become an important approach. In this study we aimed at comparing the post-operative analgesic effects of intraperitoneal levobupivacaine plus fentanyl and levobupivacaine plus tramadol in patients after laparoscopic cholecystectomy. The objective of this study was to determine which adjuvant drug was superior to the other in terms of prolonging the analgesic effects of levobupivacaine in post-operative period of laparoscopic cholecystectomy.</p><p class="abstract"><strong>Methods:</strong> A total of 90 patients undergoing laparoscopic cholecystectomy were selected. They were divided into three groups: Group L- received 50 ml of 0.25% levobupivacaine; Group LT- received 0.25% of levobupivacaine and tramadol 2 ml (50 ml total); group LF- received 0.25% levobupivacaine plus fentanyl 2 ml (50 ml total). Postoperative pain was assessed using visual analogue scale.</p><p class="abstract"><strong>Results:</strong> The combination of levobupivacaine fentanyl and levobupivacaine tramadol<strong> </strong>was superior to plain levobupivacaine for reducing postoperative pain. No significant difference was found between Group LT and LF with respect to first analgesic and total analgesic requirement. However significant difference was found between LF and L; and between LT and L.</p><p class="abstract"><strong>Conclusions: </strong>Levobupivacaine should be used along with adjuncts either tramadol or fentanyl.</p><p class="abstract"> </p>