bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uncertainty Reduction Through Data Management in the Development, Validation, Calibration, and Operation of a Hurricane Vulnerability Model
Authors: Pinelli Jean-Paul , Da Cruz Josemar , Gurley Kurtis , Paleo-Torres Andres Santiago , Baradaranshoraka Mohammad , Cocke Steven , Shin Dongwook 
Published: November 2020

AbstractCatastrophe models estimate risk at the intersection of hazard, exposure, and vulnerability. Each of these areas requires diverse sources of data, which are very often incomplete, inconsistent, or missing altogether. The poor quality of the data is a source of epistemic uncertainty, which affects the vulnerability models as well as the output of the catastrophe models. This article identifies the different sources of epistemic uncertainty in the data, and elaborates on strategies to reduce this uncertainty, in particular through identification, augmentation, and integration of the different types of data. The challenges are illustrated through the Florida Public Hurricane Loss Model (FPHLM), which estimates insured losses on residential buildings caused by hurricane events in Florida. To define the input exposure, and for model development, calibration, and validation purposes, the FPHLM teams accessed three main sources of data: county tax appraiser databases, National Flood Insurance Protection (NFIP) portfolios, and wind insurance portfolios. The data from these different sources were reformatted and processed, and the insurance databases were separately cross-referenced at the county level with tax appraiser databases. The FPHLM hazard teams assigned estimates of natural hazard intensity measure to each insurance claim. These efforts produced an integrated and more complete set of building descriptors for each policy in the NFIP and wind portfolios. The article describes the impact of these uncertainty reductions on the development and validation of the vulnerability models, and suggests avenues for data improvement. Lessons learned should be of interest to professionals involved in disaster risk assessment and management.
On the current state of combining human and artificial intelligence for strategic organizational decision making
Authors: Trunk Anna , Birkel Hendrik , Hartmann Evi 
Published: November 2020

AbstractStrategic organizational decision making in today’s complex world is a dynamic process characterized by uncertainty. Therefore, diverse groups of responsible employees deal with the large amount and variety of information, which must be acquired and interpreted correctly to deduce adequate alternatives. The technological potential of artificial intelligence (AI) is expected to offer further support, although research in this regard is still developing. However, as the technology is designed to have capabilities beyond those of traditional machines, the effects on the division of tasks and the definition of roles established in the current human–machine relationship are discussed with increasing awareness. Based on a systematic literature review, combined with content analysis, this article provides an overview of the possibilities that current research identifies for integrating AI into organizational decision making under uncertainty. The findings are summarized in a conceptual model that first explains how humans can use AI for decision making under uncertainty and then identifies the challenges, pre-conditions, and consequences that must be considered. While research on organizational structures, the choice of AI application, and the possibilities of knowledge management is extensive, a clear recommendation for ethical frameworks, despite being defined as a crucial foundation, is missing. In addition, AI,other than traditional machines, can amplify problems inherent in the decision-making process rather than help to reduce them. As a result, the human responsibility increases, while the capabilities needed to use the technology differ from other machines, thus making education necessary. These findings make the study valuable for both researchers and practitioners.
Recent advances of DNAzyme-based nanotherapeutic platform in cancer gene therapy
Authors: Huo Wendi , Li Xiaona , Wang Bei , Zhang Haoran , Zhang Jinchao , Yang Xinjian , Jin Yi 
Published: November 2020

AbstractDeoxyribozyme (or denoted as DNAzyme), which is produced by in vitro screening technology, has gained extensive research interest in the field of biomedicine due to its high catalytic activity and structure identification. This review introduces the structural characteristics of RNA-cleaving DNAzyme and its application potential in cancer gene therapy, which plays a significant role in cancer-related gene inactivation by specifically cleaving target mRNA and inhibiting the expression of the corresponding protein. However, the low delivery efficiency and cellular uptake hindered the widespread usage of DNAzyme in gene therapy of cancers. Emerging nanotechnology holds great promise for DNAzyme to overcome these obstacles. This review mainly focuses on DNAzyme-based nanotherapeutic platforms in gene therapy of cancers, including oncogene antagonism therapy, treatment resistance gene therapy, immunogene therapy, and antiangiogenesis gene therapy. We also revealed the potential of DNAzyme-based nanotherapeutic platforms as emerging cancer therapy approaches and their security issues.
Tropically constructed Lagrangians in mirror quintic threefolds
Authors: Mak Cheuk Yu , Ruddat Helge 
Published: November 2020

AbstractWe use tropical curves and toric degeneration techniques to construct closed embedded Lagrangian rational homology spheres in a lot of Calabi-Yau threefolds. The homology spheres are mirror dual to the holomorphic curves contributing to the Gromov-Witten (GW) invariants. In view of Joyce’s conjecture, these Lagrangians are expected to have special Lagrangian representatives and hence solve a special Lagrangian enumerative problem in Calabi-Yau threefolds.We apply this construction to the tropical curves obtained from the 2,875 lines on the quintic Calabi-Yau threefold. Each admissible tropical curve gives a Lagrangian rational homology sphere in the corresponding mirror quintic threefold and the Joyce’s weight of each of these Lagrangians equals the multiplicity of the corresponding tropical curve.As applications, we show that disjoint curves give pairwise homologous but non-Hamiltonian isotopic Lagrangians and we check in an example that$>300$mutually disjoint curves (and hence Lagrangians) arise. Dehn twists along these Lagrangians generate an abelian subgroup of the symplectic mapping class group with that rank.
COVID-19 symptoms, duration, and prevalence among healthcare workers in the New York metropolitan area
Authors: Ganz-Lord Fran A. , Segal Kathryn R. , Rinke Michael L. 
Published: November 2020

AbstractObjective:To evaluate symptoms, workforce implications, and testing patterns related to the coronavirus disease 2019 (COVID-19) pandemic among healthcare workers (HCWs) in the New York metropolitan area during spring 2020.Design:Retrospective cohort study of occupational health services (OHS) records.Setting:A large, urban, academic medical center with 5 inpatient campuses and multiple ambulatory centers throughout Bronx and Westchester counties.Participants:We included HCWs who called OHS to report COVID-19 symptoms and had either severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) or IgG antibody testing.Methods:We analyzed the impact of COVID-19–related symptoms on (1) time from symptom onset to return to work, (2) the results of SARS-CoV-2 nasopharyngeal PCR testing, and (3) the results of SARS-CoV-2 IgG antibody testing in HCWs with mild-to-moderate COVID-19.Results:The median time from symptom onset until return to work for HCWs who did not require hospitalization was 15 days (interquartile range, 10–22). Shortness of breath, fever, sore throat, and diarrhea were significantly associated with longer durations from symptom onset to return to work. Among symptomatic HCWs who had PCR testing during the study period, 51.9% tested positive. Of the previously symptomatic HCWs who had IgG antibody testing, 55.4% had reactive tests. Ageusia was associated with having both positive PCR and reactive antibody tests. Sore throat was associated with both negative PCR and nonreactive antibody tests.Conclusion:HCWs with COVID-19 who did not require hospitalization still had prolonged illness. Shortness of breath, fever, sore throat, and diarrhea are associated with longer durations of time away from work.
Asylum seekers and refugees in Northern Ireland: the impact of post-migration stressors on mental health
Authors: Murphy F. , Vieten U. M. 
Published: November 2020

AbstractObjectives:In recent years, Northern Ireland has seen an increase in the numbers of asylum seekers and refugees. Given its status as a post-conflict region, this is a relatively new phenomenon for the area. Northern Ireland is also the only part of the United Kingdom (UK) without a refugee integration strategy. In 2016, we conducted an extensive study for the racial equality unit of the Office of the First and Deputy First Minister in Stormont on the everyday life experience of asylum seekers and refugees in Northern Ireland with view to understanding how service delivery and notions of integration/inclusion impact.Methods:This was a mixed methods study using quantitative survey methods and in-depth semi-structured interviews with service providers, asylum seekers, refugees and new UK citizens. We examined a range of service provision such as education, labour, legal provision, housing and health.Results:This article examines the issue of mental health with respect to asylum seekers and refugees in Northern Ireland. The results delineate how asylum seekers and refugee’s mental health is dramatically impacted by the asylum system in Northern Ireland (and hence, the UK) and the dearth thereof, of particular and necessary supports and access issues in the space of health and mental health in Northern Ireland. We describe how post-migration stressors experienced through the UK asylum system further compound mental health issues. The findings provide a focus on the asylum system, housing and employment.Conclusions:Our research found a dearth of mental health supports in Northern Ireland and concluded that the asylum system in the UK (as a form of post-migration stressor) further exacerbates and contributes to poor mental health and well-being for many asylum seekers and refugees.
Prevalence of Diarrheagenic Escherichia coli (DEC) and Salmonella spp. with zoonotic potential in urban rats in Salvador, Brazil
Authors: Pimentel Sobrinho C. , Lima Godoi J. , Neves Souza F. , Graco Zeppelini C. , Espirito Santo V. , Carvalho Santiago D. , Sady Alves R. , Khalil H. , Carvalho Pereira T. , Hanzen Pinna M. , Begon M. , Machado Cordeiro S. , Neves Reis J. , Costa F. 
Published: November 2020

Abstract
Studies evaluating the occurrence of enteropathogenic bacteria in urban rats (Rattus spp.) are scarce worldwide, specifically in the urban environments of tropical countries. This study aims to estimate the prevalence of diarrhoeagenic Escherichia coli (DEC) and Salmonella spp. with zoonotic potential in urban slum environments. We trapped rats between April and June 2018 in Salvador, Brazil. We collected rectal swabs from Rattus spp., and cultured for E. coli and Salmonella spp., and screened E. coli isolates by polymerase chain reaction to identify pathotypes. E. coli were found in 70% of Rattus norvegicus and were found in four Rattus rattus. DEC were isolated in 31.3% of the 67 brown rats (R. norvegicus). The pathotypes detected more frequently were shiga toxin E. coli in 11.9%, followed by atypical enteropathogenic E. coli in 10.4% and enteroinvasive E. coli in 4.5%. From the five black rats (R. rattus), two presented DEC. Salmonella enterica was found in only one (1.4%) of 67 R. norvegicus. Our findings indicate that both R. norvegicus and R. rattus are host of DEC and, at lower prevalence, S. enterica, highlighting the importance of rodents as potential sources of pathogenic agents for humans.
An evidence-based review of the use of vasoactive and inotropic medications in post-operative paediatric patients after cardiac surgery with cardiopulmonary bypass from 2000 to 2020
Authors: King Caitlin E. , Thompson Elizabeth J. , Foote Henry P. , Zimmerman Kanecia O. , Hill Kevin D. , Chamberlain Reid , Hornik Christoph P. 
Published: November 2020

AbstractBackground:Infants with moderate-to-severe CHD frequently undergo cardiopulmonary bypass surgery in childhood. Morbidity and mortality are highest in those who develop post-operative low cardiac output syndrome. Vasoactive and inotropic medications are mainstays of treatment for these children, despite limited evidence supporting their use.Methods:To help inform clinical practice, as well as the conduct of future trials, we performed a systematic review of existing literature on inotropes and vasoactives in children after cardiac surgery using the PubMed and EMBASE databases. We included studies from 2000 to 2020, and the patient population was defined as birth – 18 years of age. Two reviewers independently reviewed studies to determine final eligibility.Results:The final analysis included 37 papers. Collectively, selected studies reported on 12 different vasoactive and inotropic medications in 2856 children. Overall evidence supporting the use of these drugs in children after cardiopulmonary bypass was limited. The majority of studies were small with 30/37 (81%) enrolling less than 100 patients, 29/37 (78%) were not randomised, and safety and efficacy endpoints differed widely, limiting the ability to combine data for meta-analyses.Conclusion:Vasoactive and inotropic support remain critical parts of post-operative care for children after cardiopulmonary bypass surgery. There is a paucity of data for the selection and dosing of vasoactives and inotropes for these patients. Despite the knowledge gaps that remain, numerous recent innovations create opportunities to rethink the conduct of clinical trials in this high-risk population.
Dosimetric comparison of intensity-modulated radiation therapy (IMRT) and field-in-field (FIF) technique for head-and-neck cancer
Authors: Thi Lan Nguyen , Dai Viet Hoang , Tai Duong Thanh , Chow James C. L. 
Published: November 2020

AbstractPurpose:This study compared the plan dosimetry between the intensity-modulated radiation therapy (IMRT) and field-in-field (FIF) technique for head-and-neck cancer using the Elekta Monaco treatment planning system (TPS).Materials and methods:A total of 20 head-and-neck cancer patients were selected in this study. IMRT and FIF plans for the patients were created on the Monaco TPS (ver. 5.11.02) using the 6-MV photon beam generated by the Elekta Synergy linear accelerator. The dose–volume histograms, maximum doses, minimum doses, mean doses of the target volumes and organs-at-risk (OARs), conformity index (CI), homogeneity index (HI) and monitor units (MUs) were determined for each IMRT and FIF plan. All IMRT plans passed the patient-specific quality assurance tests from the 2D diode array measurements (MatriXX Evolution System, IBA Dosimetry, Germany).Results:The results showed that the dose distribution to the target volumes of IMRT plans was better than FIF plans, while the dose (mean or max dose) to the OAR was significantly lower than FIF plan, respectively. IMRT and FIF resulted in planning target volume coverage with mean dose of 71·32 ± 0·76 and 73·12 ± 0·62 Gy, respectively, and HI values of 0·08 ± 0·01 (IMRT) and 0·19 ± 0·06 (FIF). The CI for IMRT was 0·98 ± 0·01 and FIF was 0·97 ± 0·01. For the spinal cord tolerance (maximum dose < 45 Gy), IMRT resulted in 39·85 ± 2·04 Gy compared to 41·37 ± 2·42 Gy for FIF. In addition, the mean doses to the parotid grand were 27·27 ± 7·48 and 48·68 ± 1·62 Gy for the IMRT and FIF plans, respectively. Significantly more MUs were required in IMRT plans than FIF plans (on average, 846 ± 100 MU in IMRT and 467 ± 41 MU in FIF).Conclusions:It is concluded that the IMRT technique could provide a better plan dosimetry than the FIF technique for head-and-neck patients.
The one-year prevalence of nonspecific back pain in public primary health care establishments among 1.7 million people in western Sweden
Authors: Thoreson Olof , Aminoff Anna , Parai Catharina 
Published: November 2020

Abstract

Aim:
The one-year prevalence of diagnosed nonspecific back pain in Sweden is not known. Thus, this observational register-based study aimed to evaluate this prevalence by using data from the Region Västra Götaland, inhabiting 1.7 million people.

Methods:
Data from 2014 to 2018 were extracted from the VEGA database register. This register holds all health data from the publicly funded health care establishments in Region Västra Götaland. Aggregated data are presented as the one-year prevalence of unique individuals diagnosed with nonspecific back pain (i.e., the ICD-10 code M54). Stratification by health care level, gender, age, and M54 sub-diagnoses were made.

Findings:
Between 2014 and 2018, the annual prevalence of diagnosed nonspecific back pain in public primary health care increased from 4.8% to 6.0% (26% increase, P < 0.001, CI 25–27%). In 2018, the one-year prevalence was 7.2% among women and 4.8% among men (50% difference, P = 0.001, CI 49–52%). The one-year prevalence increased by age, and the highest figure (11%) was seen in the age group of 80–84. Low back pain, M54.5, was the most common sub-diagnosis. The one-year prevalence was significantly higher (P < 0.001) among women in all the M54 sub-diagnoses.

Conclusion:
The one-year prevalence of diagnosed nonspecific back pain was 6% in public primary health care in 2018 and has increased since 2014. Women were diagnosed considerably more frequently than men. Publicly funded rehabilitation efforts, as well as actions focusing on the prevention of back pain, is probably money well spent.
A new path loss model based on the volumetric occupancy rate for the pine forests at 5G frequency band
Authors: Genc Abdullah 
Published: November 2020

AbstractIn this paper, a new empirical path loss model based on frequency, distance, and volumetric occupancy rate is generated at the 3.5 and 4.2 GHz in the scope of 5G frequency bands. This study aims to determine the effect of the volumetric occupancy rate on path loss depending on the foliage density of the trees in the pine forest area. Using 4.2 GHz and the effect of the volumetric occupancy rate contributes to the literature in terms of novelty. Both the reference measurements to generate a model and verification measurements to verify the proposed models are conducted in three different regions of the forest area with double ridged horn antennas. These regions of the artificial forest area consist of regularly sorted and identical pine trees. Root mean square error (RMSE) and R-squared values are calculated to evaluate the performance of the proposed model. For 3.5 and 4.2 GHz, while the RMSEs are 3.983 and 3.883, the values of R-squared are 0.967 and 0.963, respectively. Additionally, the results are compared with four path loss models which are commonly used in the forest area. The proposed one has the best performance among the other models with values 3.98 and 3.88 dB for 3.5 and 4.2 GHz.
Time Attitude Profiles and Health-Related Behaviors: Validation of a Spanish Version of the Adolescent and Adult Time Inventory–Time Attitudes (AATI-TA)
Authors: Vásquez-Echeverría Alejandro , Álvarez-Núñez Lucía , Mello Zena , Worrell Frank C. 
Published: November 2020

AbstractTemporal psychology constructs are an individual difference variable related to behavioral outcomes. Recent research has shown that there are different time attitude profiles based on different configurations of the six Adolescent and Adult Time Inventory-Time Attitude (AATI-TA) subscales. The objective of this study was to analyze the psychometric properties of AATI-TA scores in Uruguay and determine the existence of temporal profiles in this context. Participants were a convenience sample of 446 (36.5% males) adults in Uruguay with a mean age of 34.53 years (SD= 13.17, range 18–75 years). Participants completed a sociodemographic questionnaire, the AATI-TA, and questionnaires on intentions, behaviors, and attitudes towards healthy food consumption and physical activity. AATI-TA scores had good reliabilities (> .70). The six-factor solution was supported and invariance by gender and age group was established. We identified five profiles – Resilients, High Positives, Negatives, Present Negatives, and Moderate Positives – which were associated differently with healthy food consumption patterns. Negative profiles were related to higher levels of unhealthy food consumption.
The Ice Content of the Dorsa Argentea Formation From Radar Sounder Data
Authors: Whitten Jennifer L. , Campbell Bruce A. , Plaut Jeffrey J. 
Published: November 2020

AbstractThe Dorsa Argentea Formation (DAF) is an extensive Hesperian plains unit in the south polar region of Mars that was once ice rich and may still contain a substantial fraction of water ice. Given its 3.5‐Ga age, the possibility for massive ice in the DAF has significant implications for the preservation of volatiles during large obliquity changes. Here Mars Advanced Radar for Subsurface and Ionosphere Sounding (MARSIS) and Shallow Radar (SHARAD) sounder data are analyzed to determine whether massive water ice is present at depth by utilizing subsurface DAF reflectors to infer the loss tangent of overlying material. SHARAD (0.005 ± 0.003) and especially MARSIS (0.009 ± 0.006) loss tangent values are closer to those of dry sediment than to equatorial glaciers or the polar caps, but a fraction of remnant ice at depth may occur. Water ice is not the predominant component of the DAF, so much of the ancient ice has been lost during large obliquity changes over the past 3.5 Ga.
Analytical Prediction of Seismicity Rate Due to Tides and Other Oscillating Stresses
Authors: Heimisson Elías R. , Avouac Jean‐Philippe 
Published: November 2020

AbstractOscillatory stresses are ubiquitous on Earth and other solid‐surface bodies. Tides and seasonal signals perpetually stress faults in the crust. Relating seismicity to these stresses offers fundamental insight into earthquake triggering. We present a simple model that describes seismicity rate due to perpetual oscillatory stresses. The model applies to large‐amplitude, nonharmonic, and quasiperiodic stressing. However, it is not valid for periods similar to the characteristic time ta. We show that seismicity rate from short‐period stressing scales with the stress amplitude, but for long periods with the stressing rate. Further, that background seismicity rate r is equal to the average seismicity rate during short‐period stressing. We suggest that Aσ0 may be underestimated if stresses are approximated by a single harmonic function. We revisit Manga et al. (2019, https://doi.org/10.1029/2019GL082892), which analyzed the tidal triggering of marsquakes and provide a rescaling of their seismicity rate response that offers a self‐consistent comparison of different hydraulic conditions.