bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Concepts of the Newest Anthropology: a Review on the Monograph by N.N. Rostova “The Human Problem in Modern Philosophy”. M.: Prospect, 2020
Authors: Riabchun Natalia Petrovna 
Published: November 2020

N. N. Rostova's monograph is considered in the review as an actual textbook for the study of philosophical anthropology in the system of higher and secondary professional education. Of particular interest in this monograph is a critical understanding of the latest Western concepts that have appeared in the last two decades and have not yet been reflected in textbooks on philosophical anthropology. These are speculative realism, nature anthropology, poststructuralist anthropology, evolutionary psychology, and philosophical horror. The article compares classical and post-non-classical concepts of man, his nature, essence, life purpose and place in the universe. Modern anthropology can be called anti-anthropology, because it denies human exclusivity, reduces man either to the organic world – animals, plants and microbes, or to the inorganic world – digital technologies.
Cytokine Analysis in Patients with Different Stages of Thromboangiitis Obliterans
Authors: Shapouri-Moghaddam Abbas , Afshari Seyed Jalil Tavakkol , Saeed Modaghegh Mohammad-Hadi , Rahimi Hamid Reza , Mahmoudi Mahmoud , Fayazi Mojtaba , Ehteshamfar Seyed Morteza 
Published: November 2020

Background:
Studies suggest that cytokines are involved in the development
of both inflammatory disorders and vascular diseases.

Objective:
The changes in transforming growth factor β (TGFβ), interleukin 6 (IL6),
tumor necrosis factor α (TNFα), and interferon γ (IFNγ) with the progression of the
thromboangiitis obliterans (TAO) symptoms were investigated in this research.

Methods:
This study included 80 patients with TAO, who were selected from the
Vascular and Endovascular Research Center in Alavi Hospital, from the year 2012 to
2016. They were then categorized into three groups: Mild (migratory thrombophlebitis,
cold sensitivity or Raynaud's phenomenon, and skin discoloration), moderate (chronic
ulcers, claudication, and burning pain of the feet at night), and severe (pain at rest and
spontaneous gangrene) symptoms. The serum levels of TGFβ, IL6, TNFα, and
IFNγwere determined by the ELISA method and compared among the groups.

Results:
The first three predominant symptoms were pulse disorder (n = 76, 95.00%),
cold intolerance (n = 61, 76.25%), and claudication (n = 59, 73.75%). A comparison of
the analysis of covariance (ANCOVA) revealed that both TGFβ and IL6 were
dysregulated as the severity of the symptoms increased from the moderate to the severe
stages; however, such changes were not significant (p > 0.05). In the multiple logistic
regression model, increased TNFα levels were seen in the presence of moderate
symptoms as compared to the severe ones (p < 0.05).

Conclusion:
It could be concluded that TNFα, as part of the defining cytokineproduction
profile of T helper cells, can be significantly involved in the progression of
TAO from the moderate to the severe stages.
Novel MicroRNA Binding Site SNPs and the Risk of Clear Cell Renal Cell Carcinoma (ccRCC): A Case-Control Study
Authors: Gilyazova Irina R. , Beeraka Narasimha M. , Klimentova Elizaveta A. , Bulygin Kirill V. , Nikolenko Vladimir N. , Izmailov Adel A. , Gilyazova Gulshat R. , Pavlov Valentin N. , Khusnutdinova Elsa K. , Somasundaram Siva G. , Kirkland Cecil E. , Aliev Gjumrakch 
Published: November 2020

Background:
Renal cell carcinoma represents 3% of all adult malignancies. MicroRNAs
exhibit specific functions in various biological processes through their interaction with cellular
mRNA involved in apoptosis and cell cycle control. Recent studies have reported the potential
association of single-nucleotide polymorphisms (SNPs) in miRNA-binding sites of VHL-HIF1α
pathway genes with renal cancer development and progression.

Objective:
The objective of this study is to investigate the SNPs invoking an alteration in the nature
of interaction with miRNA binding sites of VHL-HIF1α pathway genes.

Methods:
Total 450 cases of histologically and clinically verified ccRCC and 490 controls were included
in our study. Genotyping was performed using a TaqMan PCR allelic discrimination
method. Kaplan-Meier method of statistical analysis was implemented to analyze the overall patient
survival rate.

Results :
Polymorphism rs10491534 in TSC1 gene was significantly associated with the risk of developing
advanced ccRCC. Allele G of rs1642742 in VHL gene was significantly prevalent in ccRCC
compared with the control group aged 55 and older (OR = 1.5566; CI [1.1532-2.1019]). Results
from the dominant model combining individuals with AG or AA genotype showed that the A
allele bearers of CDCP1 rs6773576 exhibited a higher risk of death compared to GG carriers (HR
3.93, 95% CI 1.76-17.21, log-rank P = 0.0033).

Conclusion:
The present study delineated the association of miRNA binding site variants in VHL-
HIF1α pathway genes with the ccRCC risk, which may affect the clinical outcomes.
2, 4, 5-Trideoxyhexopyranosides Derivatives of 4’-Demethylepipodophyllotoxin: De novo Synthesis and Anticancer Activity
Authors: Lu Yapeng , Zhu Li , Cai Rui , Li Yu , Zhao Yu 
Published: November 2020

Background:
Podophyllotoxin is a natural lignan which possesses anticancer and antiviral
activities. Etoposide and teniposide are semisynthetic glycoside derivatives of podophyllotoxin and
are increasingly used in cancer medicine.

Objective:
The present work was aimed to design and synthesize a series of 2, 4, 5-trideoxyhexopyranosides derivatives of
4’-demethylepipodophyllotoxin as novel anticancer agents.

Methods:
A divergent de novo synthesis of 2, 4, 5-trideoxyhexopyranosides derivatives of 4’-demethylepipodophyllotoxin
has been established via palladium-catalyzed glycosylation. The abilities of synthesized glycosides to inhibit the growth of
A549, HepG2, SH-SY5Y, KB/VCR and HeLa cancer cells were investigated by MTT assay. Flow cytometric analysis of
cell cycle with propidium iodide DNA staining was employed to observe the effect of compound 5b on cancer cell cycle.

Results:
Twelve D and L monosaccharides derivatives 5a-5l have been efficiently synthesized in three steps from various
pyranone building blocks employing de novo glycosylation strategy. D-monosaccharide 5b showed highest cytotoxicity on
five cancer cell lines with the IC50 values from 0.9 to 6.7 mM. It caused HepG2 cycle arrest at G2/M phase in a concentration-dependent manner.

Conclusion:
The present work leads to the development of novel 2, 4, 5-trideoxyhexopyranosides derivatives of 4’-
demethylepipodophyllotoxin. The biological results suggested that the replacement of the glucosyl moiety of etoposide with
2, 4, 5-trideoxyhexopyranosyl is favorable to their cytotoxicity. D-monosaccharide 5b caused HepG2 cycle arrest at G2/M
phase in a concentration-dependent manner.
Importance of Multiple Reinforcing Comments and Areas for Change in Optimizing Dietary and Exercise Self-Monitoring Feedback in Behavioral Weight Loss Programs: Factorial Design
Authors: Krukowski Rebecca , Kim Hyeonju , Stansbury Melissa , Li Qian , Sen Saunak , Farage Gregory , West Delia 
Published: November 2020

Background
Individualized dietary and physical activity self-monitoring feedback is a core element of behavioral weight loss interventions and is associated with clinically significant weight loss. To our knowledge, no studies have evaluated individuals’ perspectives on the composition of feedback messages or the effect of feedback composition on the motivation to self-monitor.

Objective
This study aims to assess the perceptions of feedback emails as a function of the number of comments that reinforce healthy behavior and the number of areas for change (ie, behavioral changes that the individual might make to have an impact on weight) identified.

Methods
Emailed feedback followed a factorial design with 2 factors (ie, reinforcing comments and areas for change), each with 3 levels (ie, 1, 4, or 8 comments). A total of 250 adults with overweight or obesity who were interested in weight loss were recruited from the Qualtrics research panel. Participants read 9 emails presented in a random order. For each email, respondents answered 8 questions about the likelihood to self-monitor in the future, motivation for behavioral change, and perceptions of the counselor and the email. A mixed effects ordinal logistic model was used to compute conditional odds ratios and predictive margins (ie, average predicted probability) on a 5-point Likert response scale to investigate the optimal combination level of the 2 factors.

Results
Emails with more reinforcing comments or areas for change were better received, with small incremental benefits for 8 reinforcing comments or areas for change versus 4 reinforcing comments or areas for change. Interactions indicated that the best combination for 3 of 8 outcomes assessed (ie, motivation to make behavioral changes, counselor’s concern for their welfare, and the perception that the counselor likes them) was the email with 8 reinforcing comments and 4 areas for change. Emails with 4 reinforcing comments and 4 areas for change resulted in the highest average probability of individuals who reported being very likely to self-monitor in the future.

Conclusions
The study findings suggest how feedback might be optimized for efficacy. Future studies should explore whether the composition of feedback email affects actual self-monitoring performance.
Rapid Implementation of Video Visits in Neurology During COVID-19: Mixed Methods Evaluation
Authors: Saliba-Gustafsson Erika A , Miller-Kuhlmann Rebecca , Kling Samantha M R , Garvert Donn W , Brown-Johnson Cati G , Lestoquoy Anna Sophia , Verano Mae-Richelle , Yang Laurice , Falco-Walter Jessica , Shaw Jonathan G , Asch Steven M , Gold Carl A , Winget Marcy 
Published: November 2020

Background
Telemedicine has been used for decades. Despite its many advantages, its uptake and rigorous evaluation of feasibility across neurology’s ambulatory subspecialties has been sparse. However, the COVID-19 pandemic prompted health care systems worldwide to reconsider traditional health care delivery. To safeguard health care workers and patients, many health care systems quickly transitioned to telemedicine, including across neurology subspecialties, providing a new opportunity to evaluate this modality of care.

Objective
To evaluate the accelerated implementation of video visits in ambulatory neurology during the COVID-19 pandemic, we used mixed methods to assess adoption, acceptability, appropriateness, and perceptions of potential sustainability.

Methods
Video visits were launched rapidly in ambulatory neurology clinics of a large academic medical center. To assess adoption, we analyzed clinician-level scheduling data collected between March 22 and May 16, 2020. We assessed acceptability, appropriateness, and sustainability via a clinician survey (n=48) and semistructured interviews with providers (n=30) completed between March and May 2020.

Results
Video visits were adopted rapidly; overall, 65 (98%) clinicians integrated video visits into their workflow within the first 6 implementation weeks and 92% of all visits were conducted via video. Video visits were largely considered acceptable by clinicians, although various technological issues impacted their satisfaction. Video visits were reported to be more convenient for patients, families, and caregivers than in-person visits; however, access to technology, the patient’s technological capacity, and language difficulties were considered barriers. Many clinicians expressed optimism about future utilization of video visits in neurology. They believed that video visits promote continuity of care and can be incorporated into their practice long-term, although several insisted that they can never replace the in-person examination.

Conclusions
Video visits are an important addition to clinical care in ambulatory neurology and are anticipated to remain a permanent supplement to in-person visits, promoting patient care continuity, and flexibility for patients and clinicians alike.
A Live Video Mind-Body Treatment to Prevent Persistent Symptoms Following Mild Traumatic Brain Injury: Protocol for a Mixed Methods Study
Authors: Greenberg Jonathan , Singh Tanya , Iverson Grant L , Silverberg Noah D , Macklin Eric A , Parker Robert A , Giacino Joseph T , Yeh Gloria Y , Vranceanu Ana-Maria 
Published: November 2020

Background
Every year, approximately 42 million people sustain a mild traumatic brain injury (mTBI, also known as concussion), with particularly high rates among college-aged individuals. A substantial proportion of these people (44%-64%) develop persistent symptoms that are challenging to treat, costly, and associated with significant disability. Anxiety has emerged as a risk factor for progression from acute to persistent mTBI symptoms.

Objective
This study aims to develop, adapt, and establish the feasibility of the Toolkit for Optimal Recovery after Concussions (TOR-C), an innovative mind-body program aimed at preventing persistent symptoms among young adults with mTBI and comorbid anxiety. Here, we describe the proposed study design, methodology, measurement, and treatment manuals.

Methods
In phase 1, we will conduct individual, live video qualitative interviews (up to n=20) with college-aged individuals with mTBI and comorbid anxiety to inform adaptation of the intervention and study procedures. In phase 2, an open pilot of the live video TOR-C (n=5) with exit interviews will be conducted to explore the initial feasibility, acceptability, and credibility of the program and to refine the study procedures. Phase 3 will involve conducting a feasibility randomized controlled trial (N=50) of the TOR-C versus a health education control (Health Enhancement for Concussions; HE-C), both delivered via live video, to establish feasibility of recruitment procedures (screening, eligibility, and enrollment) and data collection; feasibility, credibility, and acceptability of the live video TOR-C and HE-C (adherence, retention, fidelity, and satisfaction) following prespecified benchmarks; and a signal of improvement in outcomes.

Results
Phase 1 of the study has been approved by the Massachusetts General Hospital Institutional Review Board. Study completion is anticipated by early 2025.

Conclusions
We will develop and test the first mind-body intervention focused on prevention of persistent symptoms following mTBI in young adults with comorbid anxiety problems. This will allow us to establish feasibility markers in postconcussive symptoms, anxiety, disability, and fear avoidance to inform a future efficacy trial of the TOR-C versus HE-C.

International Registered Report Identifier (IRRID)
PRR1-10.2196/25746
"The dark side of the Moon": unknown negative genes in the positive RNA genomes of coronaviruses
Authors: Oleg Prof. Zhirnov , Zhirnov O P , Poyarkov S V 
Published: November 2020

Coronavirus family has a single-stranded RNA genome encoding 25-30
proteins in different viruses by the mechanism of positive-sense
strategy. Extended open reading translation frames (genes) were found to
locate under a negative-sense polarity in all coronaviruses genomes.
These negative-sense genes varies in the range of 150-450 nt to encode
negative genes polypeptides (NGP) with mol. wt. 5-30 kDa. It implies
that coronaviruses besides positive genome strategy may have “a dark
side of the Moon” expressing genes and virions through the negative
strategy. It is noteworthy, that positive- and negative-sense genes
colocolized in the same RNA regions of coronavirus genome, so called
stacking genes. Ambisense stacking of genes in coronavirus genomes
significantly increases virus diversity, genetic potential and extend
virus-host adaptation pathway possibilities.
Music education as manipulation – a proposal for playing
Authors: Thorgersen Ketil 
Published: November 2020

An important feature of music is its ability to affect people in unpredictable and deep ways. Music has therefore been used to oppress and (mis)lead people by dictatorships, religious leaders and supermarkets amongst others, and to help lure people into acting in ways that are beneficial for the manipulators. Such forms of ethically dubious musical manipulation happen because of the sublime potential of music to do something to people, and in such a way that they have few ways to defend themselves against it. Thus, the power of music is also the reason people seek out the unforeseen affects and effects in their encounters with the arts. Building on a theory of aesthetic communication, and seeking support from Deleuze and Guattari (1994), Dewey (2005) and Spinoza (Spinoza & Lagerberg, 2001), the aim of this article is to propose the term manipulation as a tool in music education or as a vehicle for teachers and researchers to help frame activities in music education as meaningful for aesthetic communication. I argue that manipulation is a necessary component of all art and aesthetic communication, that, despite its usual negative connotations, manipulation is an act that can be used for good or bad purposes, and that music education has a duty to educate pupils in artistic manipulation. Manipulation is considered action, and as such, it is argued that it can take on any value from good to bad depending on the intentions and effects it causes. This article invites a discussion of possible ways of designing music education that revolve around tinkering with aesthetic communication, and wherein desirable manipulation plays a vital role, and outcomes-based curricula are replaced with an alternative more compatible with the arts.
THEATER OF THE EARLY MODERN PERIOD: BETWEEN “SCHOOL” AND “CITY”
Authors: Лурье Зинаида Андреевна 
Published: November 2020

В статье на материале позднесредневековой Германии рассматривается место театра как коммуникативного канала в городском пространстве. Автор исходит из представления о том, что в диалоге между властью и городской общиной важнейшую роль играли паратеатральные практики (процессии, различные игры и пр.), тогда как собственно спектакли начиная с первых десятилетий XV в. были каналом внутригородской коммуникации. К производству спектаклей имели доступ разные сословия, что обуславливало в целом нейтральный характер театральных текстов, выполняющих главным образом консервативную и развлекательную функции. Изменилась ли роль театра в связи с развитием гуманизма и с институциализацией театра внутри школьной системы в раннее Новое время? В статье предпринята попытка ответить на этот вопрос на материале творчества раннего протестантского литератора Сикста Бирка. В историографии его творчество рассматривается через призму политического измерения, а сам он – как весьма рафинированный, интеллектуальный литератор. Однако, как считает автор статьи, тексты Бирка мало отличаются от позднесредневековой традиции. Анализ показывает, что Бирк утверждает все те же ценности стабильности и транслируют прежние топосы. Однако «Школа» явно подталкивает «Город» к осмыслению социального опыта.The article, based on the material of late medieval Germany, examines the place of the theater as a communicative channel in urban space. The author proceeds from the idea that paratheatre (processions, various games, etc.) played an important role in the dialogue between the authorities and the city community, whereas performances themselves, starting from the first decades of the 15th century, were a channel of intercity communication. Different classes had access to the production of performances, which led to the generally neutral nature of theatrical texts that performed mainly conservative and entertaining functions. Has the role of the theater changed in connection with the development of humanism and institutionalization of the theater within the school system in the Early Modern Period? The article attempts to answer this question on the material of the works of the early Protestant writer Sixt Birck. In historiography, his works are viewed through the prism of the political dimension, and he is classified as a very refined, intellectual writer. However, according to the author of the article, Birck’s texts differ little from the late medieval tradition. The analysis shows that Birck maintains the same values of stability and medieval topoi. However, the "School" clearly pushes the "City" to comprehend social experience.
Prognosis of paradoxical low-flow low-gradient aortic stenosis after transcatheter aortic valve replacement
Authors: Saito Yukihiro , Lewis Erik E. , Raval Amish , Gimelli Giorgio , Jacobson Kurt , Osaki Satoru 
Published: November 2020

Aims
In paradoxical low-flow low-gradient severe aortic stenosis (PLFLG AS) patients, stroke volume index (SVI) is reduced despite preserved left ventricular ejection fraction (LVEF). Although reduced SVI is already known as a poor prognostic predictor, the outcomes of PLFLG AS patients after transcatheter aortic valve replacement (TAVR) have not been clearly defined. We retrospectively investigated the post-TAVR outcomes of PLFLG AS patients in comparison with normal-flow high-gradient aortic stenosis (NFHG AS) patients.

Methods
The current observational study included 245 patients with NFHG AS (mean transaortic pressure gradient ≥40 mmHg and LVEF ≥ 50%) and 48 patients with PLFLG AS (mean transaortic pressure gradient <40 mmHg, LVEF ≥ 50% and SVI < 35 ml/m2). The endpoints were all-cause mortality, hospitalization for valve-related symptoms or worsening congestive heart failure and New York Heart Association functional class III or IV.

Results
PLFLG AS patients had a significantly higher proportion with a history of atrial fibrillation/flutter as compared with NFHG AS patients. All-cause mortality of PLFLG AS patients was worse than that of NFHG AS patients (P = 0.047). Hospitalization for valve-related symptoms or worsening congestive heart failure was more frequent in PLFLG AS patients than in NFHG AS patients (P = 0.041). New York Heart Association functional class III–IV after TAVR was more frequently observed in PLFLG AS patients (P = 0.019).

Conclusion
The outcomes of PLFLG AS patients were worse than those of NFHG AS patients in this study. Preexisting atrial fibrillation/flutter was frequent in PLFLG AS patients, and may affect their post-TAVR outcomes. Therefore, closer post-TAVR follow-up should be considered for these patients.
Review of updated regulations and product license categories for veterinary vaccines in the United States
Authors: Erdman Matthew M. , Clough Nancy E. , Hauer Paul J. 
Published: November 2020

Abstract
The USDA continues to consider and implement regulatory pathways for evolving scenarios, needs, and technologies. The intent of this report is to make veterinarians and other users of veterinary biologics aware of recent regulatory additions and changes, particularly in the area of veterinary vaccines. These include new licensure pathways to increase product availability, standardization of labeling, and increased transparency regarding adverse event reports and the efficacy and safety studies accepted by the USDA for product licensure. This report did not undergo scientific peer review.