bluuebunny/crossref_metadata_2025_split huggingface dataset:
CEP41‐mediated ciliary tubulin glutamylation drives angiogenesis through AURKA‐dependent deciliation
Authors: Ki Soo Mi , Kim Ji Hyun , Won So Yeon , Oh Shin Ji , Lee In Young , Bae Young‐Ki , Chung Ki Wha , Choi Byung‐Ok , Park Boyoun , Choi Eui‐Ju , Lee Ji Eun 
Published: December 2019

AbstractThe endothelial cilium is a microtubule‐based organelle responsible for blood flow‐induced mechanosensation and signal transduction during angiogenesis. The precise function and mechanisms by which ciliary mechanosensation occurs, however, are poorly understood. Although posttranslational modifications (PTMs) of cytoplasmic tubulin are known to be important in angiogenesis, the specific roles of ciliary tubulin PTMs play remain unclear. Here, we report that loss of centrosomal protein 41 (CEP41) results in vascular impairment in human cell lines and zebrafish, implying a previously unknown pro‐angiogenic role for CEP41. We show that proper control of tubulin glutamylation by CEP41 is necessary for cilia disassembly and that is involved in endothelial cell (EC) dynamics such as migration and tubulogenesis. We show that in ECs responding to shear stress or hypoxia, CEP41 activates Aurora kinase A (AURKA) and upregulates expression of VEGFA and VEGFR2 through ciliary tubulin glutamylation, as well as leads to the deciliation. We further show that in hypoxia‐induced angiogenesis, CEP41 is responsible for the activation of HIF1α to trigger the AURKA‐VEGF pathway. Overall, our results suggest the CEP41‐HIF1α‐AURKA‐VEGF axis as a key molecular mechanism of angiogenesis and demonstrate how important ciliary tubulin glutamylation is in mechanosense‐responded EC dynamics.
DOCK5 regulates energy balance and hepatic insulin sensitivity by targeting mTORC1 signaling
Authors: Lai Yerui , Zhao Anjiang , Tan Minghong , Yang Mengliu , Lin Yao , Li Shengbing , Song Jinlin , Zheng Hongting , Zhu Zhiming , Liu Dongfang , Liu Chaohong , Li Ling , Yang Gangyi 
Published: December 2019

AbstractThe dedicator of cytokinesis 5 (DOCK5) is associated with obesity. However, the mechanism by which DOCK5 contributes to obesity remains completely unknown. Here, we show that hepatic DOCK5 expression significantly decreases at a state of insulin resistance (IR). Deletion of DOCK5 in mice reduces energy expenditure, promotes obesity, augments IR, dysregulates glucose metabolism, and activates the mTOR (Raptor)/S6K1 pathway under a high‐fat diet (HFD). The overexpression of DOCK5 in hepatocytes inhibits gluconeogenic gene expression and increases the level of insulin receptor (InsR) and Akt phosphorylation. DOCK5 overexpression also inhibits mTOR/S6K1 phosphorylation and decreases the level of raptor protein expression. The opposite effects were observed in DOCK5‐deficient hepatocytes. Importantly, in liver‐specific Raptor knockout mice and associated hepatocytes, the effects of an adeno‐associated virus (AAV8)‐ or adenovirus‐mediated DOCK5 knockdown on glucose metabolism and insulin signaling are largely eliminated. Additionally, DOCK5–Raptor interaction is indispensable for the DOCK5‐mediated regulation of hepatic glucose production (HGP). Therefore, DOCK5 acts as a regulator of Raptor to control hepatic insulin activity and glucose homeostasis.
Optimized modelling on lateral separation of twin pontoon-net floating breakwater
Authors: Fitriadhy A. , Abdullah S. F. , Hairil M. , Ahmad M. F. , Jusoh A. 
Published: December 2019

Since the attribute of wave energy transmission is susceptible to lateral separation (S/D) between twin pontoons of floating breakwater, employing improper S/D may cause ineffective attenuation in the amount of wave energy. This paper presents a numerical optimization modelling aimed at obtaining the optimum S/D through Genetic Algorithm (GA) approach. The artificial intelligence is primarily employed to minimize transmission of wave energy coefficients ( ) whereas maximize energy dissipation coefficient ( ). To achieve such demand, a numerical simulation implementing a MATLAB code as an interface between the Genetic Algorithm and a CFD program is applied. Several parameters for the effects of various wavelengths and ratios of S/D including a set of criteria have been considered in the simulation, where the optimum solution is chosen from various populations. The results demonstrated that the current GA analysis is efficient that can search a global trade-offs between and to determine an optimum S/D. The was minimized to less than 0.3 as compared to existing model ( ) while maximizing to greater than 0.95. Hence, the optimisation algorithm can serve as a useful engineering tool for a conceptual design to determine an optimum S/D for twin pontoons of floating breakwater.
Finite element method investigation of geometrical influences of adhesive and patch in the safety for 90° elbow piping system
Authors: Gadi Ibrahim , Meriem-Benziane Madjid , Bachir Bouiadjra B. 
Published: December 2019

Piping system elbow study is the most important part in all fields of hydrocarbons transportation which presents the behaviour of circumferential crack at elbow extrados. The effect of geometry of adhesive and patch in the crack elbow is important in pipeline safety. This study shows the details for along the direction of the circumferential elbow crack by three dimensional (FEM) which is used to determine the stress intensity factor at 90° elbow for two cases: firstly, without patch and secondly, repaired with composite patch. This method allows to predict the behaviour of cracked elbow through the analysis of crack propagation under the internal different pressures taking into consideration the operating conditions. The geometry and nature of composite patch proved that the increase of patch thickness leads to decrease the SIF from 7 MPa.m1/2 to 6.15 MPa.m1/2. It can be concluded that the repairing by composite materials leads to reduce the stress intensity factor with patch which not only can augment the lifetime of pipeline but also decreasing the costs and the pollution.
Sealing performance analysis of composite gaskets made of silicone rubber filled with ramie natural fibers
Authors: W. S. Widodo , Soenoko R. , Choiron M. A. , Sonief A. A. 
Published: December 2019

Silicon rubber gaskets are commonly used in many industries for low pressure sealing conditions only. The research studies about the sealing performance improvement of a novel composite gasket made of the silicone rubber filled with ramie natural fibers in a bolted joint connection. In this research the sample of gasket consists of 4 different types of gasket i.e. a pure silicone rubber gasket and the silicone rubber composite gasket with 1, 2 and 3 layers of ramie fiber woven. The gaskets are tested using a water pressure testing equipment with a variation of internal fluid pressure and difference torques at 8 N.m, 12 N.m, 16 N.m and 20 N.m. The sealing performance is measured based on the maximum fluid pressure that can be hold by the gaskets before the fluid leaking occurred. The results show that the silicone rubber composite gaskets have better sealing performance comparing with the pure silicone rubber gaskets where the silicon rubber gaskets capable to hold the internal fluid pressure until around 5 times rather than pure silicon rubber gaskets (0.17 MPa comparing with 0.90 MPa). On the other hand the sealing performance of the composite gasket with 3 layers is almost 2 times better than the composite gasket with 1 layer and around 1.5 times better than the composite gasket with 2 layer of fiber woven.
Salud mental en estudiantes de pregrado de la Facultad de Medicina de la Universidad Nacional Mayor de San Marcos
Authors: Perales Alberto , Izaguirre Manuel , Sánchez Elard , Barahona Lorenzo , Martina Martha , Amemiya Isabel , Delgado Ana , Domínguez Imelda , Pinto Miguel , Cuadros Raúl , Padilla Alberto 
Published: December 2019

Introducción. Estudios previos evidencian problemas de salud mental en estudiantes de pre-grado de la Facultad de Medicina de la Universidad Nacional Mayor de San Marcos (UNMSM). Objetivo. Evaluar si existen diferencias entre la frecuencia de problemas de salud mental entre los estudiantes de primer año, y el resto de años de estudio, en alumnos de las cinco escuelas profesionales de la Facultad de Medicina de la UNMSM. Métodos. Estudio transversal. Se utilizaron instrumentos validados para evaluar problemas de salud mental: intento suicida, pensamiento homicida, conducta disocial, problemas con el alcohol, depresión y angustia. Adicionalmente, se midieron niveles de resiliencia. Se incluyeron estudiantes de todas las escuelas profesionales de la Facultad de Medicina, en dos grupos de análisis: estudiantes de primer año y estudiantes de los otros años. Resultados. Se evidenció que en alumnos de primer año se encontró un 7,5% de intento suicida, 18,9% de conducta disocial y 21,9% de pensamiento homicida. Asimismo, se encontró un 4,8% de problemas con el alcohol, 8,5% de depresión y 3,2% de angustia. La frecuencia de problemas de salud mental fue mayor según transcurren los años de estudio, con diferencias estadísticamente significativas sólo en depresión, angustia y problemas con el alcohol. El 29,3% de encuestados tuvo bajo nivel de resiliencia. Conclusión. Se encontró frecuencias preocupantes de problemas de salud mental en los estudiantes de pregrado de la Facultad de Medicina de la UNMSM, aunque un porcentaje de alumnos ingresa a la universidad con problemas de salud mental. El entorno universitario sería factor agravante en depresión, ansiedad y problemas con el alcohol.
POLA ASUH ANAK PADA IBU PEKERJA PABRIK DALAM PERSPEKTIF FIQIH PARENTING
Authors: Syamsuri Syamsuri 
Published: December 2019

Abstract. This paper examines child parenting that occurs in working mothers in Paiton Probolinggo, East Java. On the one hand, the demands of fulfilling the family economy forced the mothers to work hard outside the home. On the other hand, they are required to care for and assist children in proper parenting intensely. Based on this fact, it is necessary to study how changes in parenting happened to work mothers and how fathers and mothers worked together in families to do co-parenting. These two problems are then examined from a gender mainstreaming perspective and then analyzed through fiqh so that the concept of gender relations in parenting can be found in accordance with the values of Islamic teachings. Through a case study approach, collecting, processing, and analyzing data with qualitative research principles, this study resulted in the finding of delegating parenting from parents to others resulting in low-quality supervision and assistance from caregivers to children and low levels of child satisfaction. This study also found no occurrence of parenting that involved fathers and mothers in the principle of partnership and ignorance. In the perspective of parenting fiqh, the parenting patterns that occur in Paiton Probolinggo are not in accordance with the values and laws of parenting fiqh. Abstrak. Tulisan ini mengkaji tentang pola asuh anak yang terjadi pada ibu pekerja di Paiton Probolinggo Jawa Timur. Di satu sisi tuntutan pemenuhan ekonomi keluarga memaksa para ibu untuk bekerja keras di luar rumah. Di sisi yang lain mereka dituntut untuk secara intens merawat dan mendampingi anak dalam pola asuh yang tepat. Berdasarkan fakta ini, perlu dikaji bagaimana perubahan pola asuh yang terjadi pada ibu pekerja serta bagaimana kerjasama ayah dan ibu dalam keluarga melakukan coparenting. Kedua permaslahan tersebut selanjutnya dikaji dari perspektif gender mainstreaming untuk kemudian dianalisis melalui fiqih sehingga dapat ditemukan konsep relasi gender dalam pengasuhan anak yang berkesesuain dengan nilai nilai ajaran Islam. Melalui pendekatan case study, mengumpulkan, mengolah, dan menganalisis data dengan prinsip-prinsip penelitian kualitatif, kajian ini menghasilkan temuan adanya pendelegasian pola asuh anak dari orang tua kepada orang lain yang berakibat rendahnya mutu pengawasan dan pemdampingan dari pengasuh terhadap anak serta rendahnya tingkat kepuasan anak. Kajian ini juga menemukan tidak terjadinya coparenting yang melibatkan ayah dan ibu dalam prinsip kemitraan dan kesalingan. Dalam perspektif fiqih parenting, pola pengasuhan anak yang terjadi di Paiton Probolinggo ini tidak sesuai dengan nilai dan prinsip fiqih parenting.
The Learning Strategies Used by EFL Students in Learning English
Authors: Mega Dinda Hartina , Santihastuti Asih , Wahjuningsih Eka 
Published: December 2019

ABSTRACTThis research was aimed to focus on the most frequently used strategy by the successful and unsuccessful senior high school students and describe the difference of strategy used by them. This was a survey design with a questionnaire as the instrument. The participants were 40 students consisting of 20 successful students and 20 unsuccessful students of tenth grade in SMAN 2 Jember. The writer distributed SILL questionnaires to observe their Language Learning Strategy (LLS) based on Oxford (1990), which covers six categorizes of strategies namely cognitive, metacognitive, memory-related, compensatory, affective, and social. The statistical analysis showed that metacognitive became the most frequently learning strategy used by successful students in scale of high use, while the unsuccessful students were medium users of cognitive strategy. It also indicated successful learners employed all six categorizes of strategies in a highly frequencies than the unsuccessful ones. This makes the assumption that successful students have the ability to plan clear goals, control, review, and evaluate their learning rather than unsuccessful students who focus more on the way they think, memorize, summarize, and repeat the learning.ABSTRAKPenelitian ini bertujuan untuk fokus pada strategi yang paling sering digunakan oleh siswa SMA yang sukses dan kurang sukses serta menggambarkan perbedaan strategi yang digunakan oleh mereka. Penelitian ini merupakan penelitian survey dengan instrument berupa kuesioner, sedangkan tanggapan siswa dalam memilih strategi dibahas secara deskriptif. Partisipan adalah 40 siswa yang terdiri dari 20 siswa yang sukses dan 20 siswa yang tidak sukses dari kelas sepuluh di SMAN 2 Jember. Penulis membagikan kuesioner SILL untuk mengamati Language Learning Strategy (LLS) atau strategi pembelajaran bahasa mereka berdasarkan teori Oxford (1990, yang dikategorikan menjadi enam macam strategi, yaitu kognitif, metakognitif, memori, kompensatori, afektif, dan sosial. Menurut hasil statistic metacognitive menjadi strategi pembelajaran yang paling sering digunakan oleh siswa yang sukses dalam skala tinggi, sedangkan siswa yang kurang sukses adalah pengguna menengah dari strategi kognitif. Ini juga menunjukkan bahwa siswa yang sukses menggunakan keenam kategori strategi dalam frekuensi yang sangat tinggi daripada yang kurang sukses. Ini membuat asumsi bahwa siswa yang sukses memiliki kemampuan untuk merencanakan tujuan yang jelas, mengendalikan, meninjau, dan mengevaluasi pembelajaran mereka daripada siswa yang kurang sukses, yang lebih fokus pada cara mereka berpikir, menghafal, merangkum, dan mengulangi pembelajaran. How to Cite: Sartika, D. H. M., Santihastuti, A., Wahjuningsih, E. (2019). The Learning Strategies Used by EFL Students in Learning English. IJEE (Indonesian Journal of English Education), 6(1), 10-20. doi:10.15408/ijee.v6i1.12111
A Computational Study on the Effects of Molecular Structures of Di-n-butyldithiophosphate and of its Derivatives on the Stability of Their Complex Compounds with Rare-Earth Elements
Authors: Nurdeni Nurdeni , Abdullah Atje Setiawan , Ruchjana Budi Nurani , A Hardianto , A Anggraeni , A Muthalib , Bahti Husein H 
Published: December 2019

The stability of complex compounds formed from the ligand di-n-butyldithiophosphate (DBDTP) and its derivatives, with ions of rare-earth elements (REEs), such as gadolinium ion (Gd3+), is an important factor in the separation and purification processes of the elements using solvent extraction method. The complex stability is dependent, one of which, on the partial charge of the donor atom (S atom in this case) in the molecule of DBDTP or its derivatives. The more negative the partial charge of the donor atom, the more stable is the complex compound formed. The purpose of this study is to explore the effect of electron donating, and of electron withdrawing groups, as well as the effect of the structure of the butyl group in the molecules of DBDTP and or its derivatives on the partial charge of the donor atom. The method used was the semi empirical quantum mechanical calculations, i.e. the Austin Model 1 (AM1). The results of the study showed that the electron withdrawing group of -CN had resulted in the most positive charge on the donor atom, if it is on the second carbon atom of the butyl group in the DBDTP and or its derivatives. Conversely, in the same carbon atom position, the donating electron group of -CH=CH2 had generated the most negative partial charge on the donor atom. Furthermore, the results of this study also revealed that the sec-butyl isomer produced the most negative partial charge on the donor atom, among other isomers.
Optimization of Pretreatment and Hydrothermal Process of Na-X Zeolite from Kaolin and Metakaolin
Authors: Hartati Hartati , Sakti Satya Candra Wibawa , Firda Putri Bintang Dea , Saidah Chabibah 
Published: December 2019

Synthesis of Na-X zeolite was conducted from kaolin and metakaolin. Synthesis varied in its pretreatment method and hydrothermal conditions. The pretreatment methods used were: conventional alkaline, alkaline fusion and conventional fluoride. Hydrothermal conditions for the experiments were gradual temperature 40 oC (6h), 60 oC (6h), 80 oC (12h), and constant temperature 80 oC for 24 h, 100 oC for 24 and 100 oC for 48 h. Synthesized products were characterized by X-Ray Diffraction (XRD), Fourier Transform InfraRed (FTIR), Scanning Electron Microscopy-Energy Dispersive X-Ray (SEM-EDX), and N2 Isotherm Adsorption/Desorption method. The result showed that pre-treatment by conventional fluoride could not produce Na-X zeolite, synthesis by conventional alkaline and alkaline fusion with hydrothermal at 100 oC (48h), 100 oC (24 h), and gradual temperature produce Na-X zeolite with Na-P1 or Na-A zeolite as impurities, while synthesis from metakaolin by conventional alkaline with hydrothermal at 80 oC for 24 hours produced pure Na-X zeolite. Na-X zeolite and NaP1 zeolite with hierarchical pores were synthesized through alkali fusion with hydrothermal at 100 oC for 24 hours.
Prostitusi Remaja dan Ketahananan Keluarga
Authors: Ulfiah Ulfiah , Hannah Neng 
Published: December 2019

Tujuan penelitian ini adalah; pertama, untuk mengungkapkan fenomena prostitusi remaja putri di Cianjur dilihat dari karakteristik tempat prostitusi, karakteristik pelaku dan korban serta mekanisme prostitusi yang terjadi; dan kedua, untuk mengetahui bagaimana kondisi ketahanan keluarga remaja putri yang menjadi korban. Penelitian ini menggunakan metode deskriptif analisis dengan menguji teori sebagai sebuah fenomena di lapangan melalui pendekatan kualitatif yang bertujuan untuk mengungkap realita yang terjadi pada remaja putri yang terlibat pada kegiatan prostitusi. Temuan hasil lapangan kemudian dianalisis dengan metode genealogi Foucault sehingga peneliti mengidentifikasi kekuasaan-kekuasaan apa/mana saja yang berkaitan dengan fenomena prostitusi remaja putri dan ketahanan keluarga. Hasil penelitian diperoleh bahwa, Prostitusi remaja putri di Cianjur dilihat dari karakteristik tempat prostitusi, karakteristik pelaku dan korban serta mekanisme prostitusi yang terjadi. Pada penelitian ini ditemukan ada empat macam pelaku perdagangan anak untuk prostitusi, yaitu pacar, teman, dan mucikari.
Integrated Care Models and Child Health: A Meta-analysis
Authors: Wolfe Ingrid , Satherley Rose-Marie , Scotney Elizabeth , Newham James , Lingam Raghu 
Published: December 2019

CONTEXT:
Integrated care models may improve health care for children and young people (CYP) with ongoing conditions.

OBJECTIVE:
To assess the effects of integrated care on child health, health service use, health care quality, school absenteeism, and costs for CYP with ongoing conditions.

DATA SOURCES:
Medline, Embase, PsycINFO, Cumulative Index to Nursing and Allied Health Literature, and the Cochrane Library databases (1996–2018).

STUDY SELECTION:
Inclusion criteria consisted of (1) randomized controlled trials, (2) evaluating an integrated care intervention, (3) for CYP (0–18 years) with an ongoing health condition, and (4) including at least 1 health-related outcome.

DATA EXTRACTION:
Descriptive data were synthesized. Data for quality of life (QoL) and emergency department (ED) visits allowed meta-analyses to explore the effects of integrated care compared to usual care.

RESULTS:
Twenty-three trials were identified, describing 18 interventions. Compared with usual care, integrated care reported greater cost savings (3/4 studies). Meta-analyses found that integrated care improved QoL over usual care (standard mean difference = 0.24; 95% confidence interval = 0.03–0.44; P = .02), but no significant difference was found between groups for ED visits (odds ratio = 0.88; 95% confidence interval = 0.57–1.37; P = .57).

LIMITATIONS:
Included studies had variable quality of intervention, trial design, and reporting. Randomized controlled trials only were included, but valuable data from other study designs may exist.

CONCLUSIONS:
Integrated care for CYP with ongoing conditions may deliver improved QoL and cost savings. The effects of integrated care on outcomes including ED visits is unclear.