bluuebunny/crossref_metadata_2025_split huggingface dataset:
The m6A reader protein YTHDC2 is a potential biomarker and associated with immune infiltration in head and neck squamous cell carcinoma
Authors: Li Yang , Zheng Ji-Na , Wang En-Hao , Gong Chan-Juan , Lan Keng-Fu , Ding XiaoJun 
Published: November 2020

Background
Increasing evidence has shown that N6-methyladenosine (m6A) RNA methylation regulators have important biological functions in human cancers. However, there are few studies on the value of m6A reader protein YTHDC2 in the diagnosis and tumor-infiltrating of head and neck squamous cell carcinoma (HNSCC). Therefore, it is important to understand the potential clinical value of YTHDC2 in the prognosis and immune infiltration of HNSCC.

Methods
In this study, gene expression profiles and the corresponding clinical information of 270 HNSCC patients were downloaded from the Gene Expression Omnibus (GEO) database. The gene co-expression network was established to verify whether YTHDC2 was related to the prognosis of HNSCC and verified again in the public database. The correlations between YTHDC2 and immune infiltration was investigated via Tumor Immune Estimation Resource (TIMER) and Gene Expression Profiling Interactive Analysis (GEPIA).

Results
The results showed that YTHDC2 appeared in the blue module related to survival time and survival state and had a close correlation with the prognosis and immune infiltration level of HNSCC in public database. Patients with low expression of YTHDC2 had poor overall survival (OS) and recurrence-free survival (RFS) than those with high expression. In addition, the expression of YTHDC2 was positively correlated with the level of CD4+ T cell subpopulations infiltration in HNSCC.

Conclusions
Through this study, we found that YTHDC2 is a tumor suppressor gene with high expression in normal tissues and low expression in tumor tissues. In addition, YTHDC2 is correlated with the immune infiltrating levels of B cells, CD8+ T cells, CD4+ T cells, neutrophils, and dendritic cells in HNSCC, which may become a potential marker for prognosis and immune infiltration of HNSCC.
Large‐Scale Multifunctional Carbon Nanotube Thin Film as Effective Mid‐Infrared Radiation Modulator with Long‐Term Stability
Authors: Sun Yue , Chang Huicong , Hu Jun , Wang Yangyang , Weng Yudong , Zhang Ce , Niu Shuai , Cao Longfei , Chen Zhao , Guo Nan , Liu Junku , Chi Jiawei , Li Guohua , Xiao Lin 
Published: November 2020

AbstractMid‐infrared tunable materials have attracted increasing attention for thermal radiation management in various applications ranging from infrared camouflage to radiative thermoregulation. Functional films based on graphene and carbon nanotubes by electrical gating are promising candidates because of their ultrawide spectral range from visible to terahertz and structural flexibility. However, challenges in practical applications remain, such as short cycle life, rapid performance degradation, and difficulties in the synthesis of large‐scale electrochromic films. In this paper, a scalable strategy to produce large‐scale mid‐infrared electrochromic films with long‐term stability is demonstrated, in which a sandwich‐structured thin film based on multiwalled carbon nanotubes (MWCNTs) is fabricated via a universal roll‐to‐roll process. By ionic liquid gating, the electrochromic films exhibit tunable thermal emissivity from ≈0.15–0.7 and excellent stability with 96% modulation retention over 3500 cycles. This mid‐infrared electromodulation behavior is mainly ascribed to the change in free carrier concentration of few‐walled carbon nanotubes in MWCNT films via a reversible ion‐induced doping process. The electrochromic films are found to enable effective radiative thermal regulation, dependent on tunable thermal emissivity. Moreover, applications in infrared displays for secret communication and infrared camouflage for varied environmental backgrounds are also demonstrated with 10 × 10 multipixel arrays.
Construct Achromatic Polymer Microlens for High‐Transmission Full‐Color Imaging
Authors: Xiong Bo , Wang Jia‐Nan , Peng Ru‐Wen , Jing Hao , Fan Ren‐Hao , Qi Dong‐Xiang , Chen Fei , Wang Mu 
Published: November 2020

AbstractTraditional microlens focuses the beam with spherical convex surface, which achieves high transmission by restraining the scattering loss yet brings spherical aberration and chromatic aberration. While recently‐developed metalens, which relies on phase modulation by elaborately designing local resonators, has realized diffraction‐limited focusing. Yet, the issues of scattering loss of nanoresonators and chromatic aberration remain serious. Here, the design strategies of both metalens and traditional microlens are combined by introducing accurate phase modulation for the wavefront into microlens designing; and a broadband, polarization‐independent, and achromatic microlens with high efficiency is realized. With concentric‐circular polymer (phenolic resin) terrace as basic building blocks, a precise thickness profile is constructed and a high‐index polymer microlens is formed by electron‐beam grayscale lithography. The diffraction‐limited focusing possesses less than 5% change of focal length when the wavelength varies from 425 to 700 nm, showing the full‐color imaging and detection with a focusing efficiency of 80% (at 700 nm wavelength). Moreover, the rotation symmetry of the microstructures of microlens makes it work for arbitrary polarization. The achromatic imaging capability of the microlens is verified by whitelight imaging. It is expected that this high‐efficiency polarization‐independent broadband achromatic polymer microlens may have wide applications in high‐efficient imaging and sensing.
Nanowire Solar Cell Above the Radiative Limit
Authors: Korzun Ksenia , Castellanos Gabriel W. , de Boer Dick K. G. , Gómez Rivas Jaime , Haverkort Jos E. M. 
Published: November 2020

AbstractA lossless solar cell operating at the Shockley–Queisser limit generates an open circuit voltage (Voc) equal to the radiative limit. At Voc, the highly directional beam of photons from the sun is absorbed and subsequently externally re‐emitted into a 4π solid angle, providing a large photon entropy loss. A solar cell can beat the Shockley–Queisser limit and approach the 46.7% ultimate limit by decreasing the output solid angle of the light emission at open circuit conditions. Here, a design for an indium phosphide single nanowire solar cell capable to operate 159 mV above the radiative limit is presented. The spontaneous emission factor is first optimized into a guided mode of the nanowire toward 68%. The authors subsequently launch a guided mode at the bottom straight part of the tapered nanowire yielding a photon escape probability of 81% for a tapering angle of θ = 1.2° and a top facet with a radius of 83 nm. When assuming homogeneous light emission along the nanowire, an outcoupling efficiency of 42% of the emitted light is obtained. The final optimization is the reduction of the emission cone toward 11 × 10−3 sr by focusing the guided mode with an external lens.
Homogeneous 3D Vertical Integration of Parylene‐C Based Organic Flexible Resistive Memory on Standard CMOS Platform
Authors: Chen Qingyu , Wang Zongwei , Lin Min , Qi Xin , Yu Zhizhen , Wu Lindong , Bao Lin , Ling Yaotian , Qin Yabo , Cai Yimao , Huang Ru 
Published: November 2020

Abstract3D integration of vertical resistive random access memory (VRRAM) with organic materials is promising for ultra‐high density flexible data storage. However, it is extremely challenging to heterogeneously fabricate an organic 3D VRRAM due to complicated issues such as chemical/thermal robustness, compatibility of organic/inorganic materials, and processes of stacking/patterning multi‐layer organic/metal films. Herein, an organic flexible 3D VRRAM based on parylene‐C is experimentally demonstrated on a standard complementary metal oxide semiconductor platform for the first time. The proposed 3D VRRAM can be homogenously fabricated based solely on parylene‐C (except the metal electrodes), significantly facilitating the 3D integration owing to chemical stability and compatibility with standard photolithography patterning. The flexible 3D organic memory arrays demonstrate great memory characteristics including retention time >105 s, endurance cycles >300, and resistance ON/OFF ratio >10. Further, a finite element analysis is established to model and investigate the scaling potential of the organic 3D VRRAM. The simulation results indicate the elevated temperature during programming could be catastrophic for ultra‐high density 3D VRRAM if the feature size approaches ≈100 nm or below, urging the containment of programming power to avoid thermal issues as well as to save energy consumption.
Fabrication of zeolitic imidazolate frameworks based mixed matrix membranes and mass transfer properties of C4H6 and N2 in membrane separation
Authors: Haq Ihtisham Ul , Wang Tao , Zhang Ao‐Shuai , Mao Heng , Khan Rehan , Xu Li‐Hao , Zhao Zhi‐Ping 
Published: November 2020

Abstract1,3‐Butadiene (BD) is a petrochemical‐based volatile organic compound, extensively used for the manufacture of synthetic rubber. There is no method reported for its recovery from nitrogen mixture. Herein, for the first time, BD is efficiently recovered by gas separation through facile and novel mixed‐metal ZIF‐8 based mixed matrix membranes (MMMs). Addition of Ni‐ZIF‐8 nanoparticles in PDMS matrix, significantly improved the penetrant‐membrane interactions and the solution‐diffusion properties of BD. Positron annihilation lifetime spectroscopy analysis showed that the well dispersion of Ni‐ZIF‐8 in PDMS enhanced the free volume of membrane and created efficient continuous paths for BD diffusion. Then, 15 wt% Ni‐ZIF‐8 MMM exhibited the BD permeance of 323 GPU and the BD/N2 ideal selectivity of 19.5, which were 60 and 81% higher than pure PDMS membrane, respectively. The simultaneous enhancement of BD permeance and BD/N2 ideal selectivity indicated that Ni‐ZIF‐8 was an effective filler applied in MMMs for efficient BD recovery.
The Role of Stressful Life Events among Women Experiencing Homelessness: An Intragroup Analysis
Authors: Rodriguez‐Moreno Sara , Panadero Sonia , Vázquez José Juan 
Published: November 2020

AbstractThe aim of this study is to examine stressful life events (SLEs) among homeless women and how SLEs were related to patterns and trajectories of homelessness. Specifically, the study aimed to replicate and build upon by Muñoz et al. (2005) by using cluster and discriminant analysis in a sample of 116 homeless women. The sample was classified based on SLEs, and the relationship between the resulting subgroups and sociodemographic characteristics, homeless trajectories, physical and mental health, and social support was examined. The results suggest that the three‐cluster solution was theoretically and structurally meaningful: (a) the “Shorter homelessness trajectories and best health and mental health” subgroup was characterized by low levels of SLEs, a shorter homeless trajectory, lower prevalence of physical and mental health problems, and lower rates of alcohol and substances consumption; (b) the “Early onset of homelessness and poorer health and poorer mental health” subgroup was characterized by a higher prevalence of childhood and adolescence SLEs, an early onset of homelessness and greater chronification, mental health problems, and alcohol consumption; and (c) the “Chronic homelessness and poorest health and mental health” subgroup was mainly characterized by a higher prevalence of typically adulthood SLEs, as well as some SLEs that may be unique to women, a greater number of periods of homelessness, physical health problems, disabilities, and substance misuse. Increased knowledge about the different subgroups and trajectories of homeless women, as well as their specific characteristics and needs, will help us design social services and policies sensitive to all these differences.
Fabricating patterned polyelectrolyte brushes by dynamic microprojection lithography for selective electroless metal deposition
Authors: Hu Fenghuai , Zhao Haili , Pan Yunfei , Yang Dasheng , Sha Jin , Gao Yang 
Published: November 2020

AbstractThe emerging need for flexible and wearable electronics has been pushing the edge of the traditional electroless deposition (ELD) technique. With the rapid development of polymer‐assisted ELD (PAELD), its time‐consuming and possess‐complicated procedures have hindered the application of the technique. Here, for purpose of addressing the challenge, the work demonstrates a highly efficient and versatile method, based on the procedure consisting of the customized polyelectrolyte brushes patterns fabrication with the assistance of mask‐free dynamic microprojection lithography and sequential selective ELD (DML‐ELD), for the fabrication of arbitrary electrode on the silicon dioxide/silicon (SiO2/Si) substrate. The resistivity of the patterned copper electrode maintained around 0.062 Ω∙mm at room temperature, indicating the high reproducibility and stability of the method. Furthermore, an interdigital copper electrode fabricated with the DML‐ELD method was coated with a poly(vinyl alcohol) sensing layer, forming a sandwich structure for the ambient humidity detection. The sensitivity of the lab‐made humidity sensor achieves 0.82 pF/%RH (<80%RH) and 19.3 pF/%RH (>80%RH). The work has demonstrated the broad prospect of the proposed DML‐ELD method in the rapid and customized manufacturing of microcircuit fabrication for electronic devices.
Polylactide films produced with bixin and acetyl tributyl citrate: Functional properties for active packaging
Authors: Stoll Liana , Domenek Sandra , Hickmann Flôres Simone , Nachtigall Sonia Marli B. , de Oliveira Rios Alessandro 
Published: November 2020

AbstractPackaging materials are decisive to preserve the quality and nutritional value of food. Polylactide (PLA) is a biodegradable polymer with adequate mechanical properties for packaging applications, but its moderate oxygen barrier properties and high UV light transmission hamper its performance as packaging for oxygen‐ and light‐sensitive products. Bixin, a carotenoid with coloring and antioxidant character, was used to improve the light barrier of PLA films plasticized or not with acetyl tri‐butyl citrate (ATBC). The films were subjected to thermal treatment mimicking polymer processing temperatures. Despite more than 74 wt% of bixin degraded during heat treatment, films were still blocking up to 95% of UVA and 90% of UVB transmission. Plasticizing PLA with ATBC accelerated up to six times the bixin release into a food simulant, which allowed to reach relevant concentrations for food preservation. In conclusion, bixin is a promising natural antioxidant and UV‐shielding additive of biodegradable packaging.
Surface functionalization of poly(vinylidene fluoride) membrane by radiation‐induced emulsion polymerization of hydroxyethyl acrylates in an aqueous medium
Authors: Mohamad Siti Fatahiyah , Karoji Muhamad Nurfalah , Mustaqim Azzian Muhammad Irfan , Mohd Hassani Muhamad Hisyamuddin , Wan Salleh Wan Norharyati 
Published: November 2020

AbstractDecades ago, surface modification of poly(vinylidene fluoride) (PVDF) membrane became an essential subject. The change is mainly to enhance the hydrophilicity properties of the membrane in order to increase the adsorption capacity, thus making as a novel adsorbent. This study aims to used radiation‐induced polymerization and compares the final properties of PVDF grafted hydroxyethyl acrylates (HEA) prepare by two different approaches. The PVDF‐grafted‐HEA has achieved either direct polymerization or emulsion polymerization. Tween‐20 has been used as a surfactant in emulsion polymerization. The final PVDF‐grafted poly‐HEA was analyzed using several different instruments to observe the changes in terms of morphological structure, topography properties, thermal stability, mechanical strength, and hydrophilicity. Significant differences were seen in morphology and contact angles properties. By emulsion polymerization, poly‐HEA grafted in the shape of micelles compare to by direct polymerization shown a thin homogenous layer. Thus, the surface roughness of PVDF by emulsion is higher lead to higher contact angles. Even though both approaches demonstrate significant changes in the physicochemical properties of the PVDF membrane, it is revealed that radiation‐induced direct polymerization approaches could achieve a hydrophilic PVDF‐grafted HEA.
Recyclable Transition Metal Catalysis using Bipyridine‐Functionalized SBA‐15 by Co‐condensation of Methallylsilane with TEOS
Authors: Han Ye Ri , Kim Jae Soon , Park Woo‐Jin , Lee Chang‐Hee , Cheon Jinwoo , Jun Chul‐Ho 
Published: November 2020

AbstractWell‐defined recyclable Pd‐ and Rh‐bipyridyl group‐impregnated SBA‐15 catalysts were prepared for C−C bond coupling reaction and selective hydrogenation reactions, respectively. These SBA‐15 derived ligands for the catalysts were prepared by direct and indirect co‐condensation method using bipyridyl‐linked methallylsilane. This indirect method, involving methoxysilane generated from methallylsilane shows higher loading efficiency of transition metal catalysts on SBA‐15 than the direct use of methallylsilane.
Allogeneic stem cell transplant in patients with acute myeloid leukemia and karnofsky performance status score less than or equal to 80%: A study from the acute leukemia working party of the European Society for Blood and Marrow Transplantation (EBMT)
Authors: Saraceni Francesco , Labopin Myriam , Forcade Edouard , Kröger Nicolaus , Socié Gerard , Niittyvuopio Riitta , Cornelissen Jan J. , Labussière‐Wallet Hélène , Blaise Didier , Choi Goda , Byrne Jenny L. , Guillerm Gaelle , Marchand Tony , Esteve Jordi , Bazarbachi Ali , Savani Bipin , Olivieri Attilio , Nagler Arnon , Mohty Mohamad 
Published: November 2020

AbstractLimited data are currently available on the outcome of patients with acute myeloid leukemia (AML) undergoing allogeneic stem cell transplantation (allo‐SCT) with a reduced performance status. We herein present the results of a registry study on 2,936 AML patients undergoing allo‐SCT in first remission (CR1) with a Karnofsky Performance Status (KPS) score less than or equal to 80%. Two‐year leukemia‐free survival (LFS), overall survival (OS) and graft‐versus‐host disease (GVHD)‐free, and relapse‐free survival (GRFS) rates were 54%, 59%, and 41%, respectively. In multivariable analysis, patients with a KPS score = 80% had lower non‐relapse mortality (NRM) and superior OS in comparison to patients with a KPS score <80% (p < 0.001). In the subgroup of patients with a KPS score =80%, a reduced‐intensity conditioning (RIC) regimen was associated with an increased risk of relapse (p = 0.002) and lower GRFS (p < 0.001) compared to myeloablative conditioning (MAC). Differently, in patients with a KPS score <80%, a RIC regimen resulted in lower NRM (p < 0.001), whereas relapse incidence did not differ, thus leading to an improved GRFS (p = 0.008) as compared to MAC. A transplant from a matched sibling donor (MSD) was associated with a reduced incidence of grade III‐IV acute GVHD (p < 0.01) and NRM (p < 0.01) in comparison to other donor types. In conclusion, allo‐SCT appears feasible in AML patients with a jeopardized KPS score. Survival is significantly affected by the conditioning intensity, which should be adjusted according to the severity of KPS impairment.
A Calix[4]arene‐Based Cyclic Dinuclear Ruthenium Complex for Light‐Driven Catalytic Water Oxidation
Authors: Noll Niklas , Würthner Frank 
Published: November 2020

AbstractA cyclic dinuclear ruthenium(bda) (bda: 2,2’‐bipyridine‐6,6’‐dicarboxylate) complex equipped with oligo(ethylene glycol)‐functionalized axial calix[4]arene ligands has been synthesized for homogenous catalytic water oxidation. This novel Ru(bda) macrocycle showed significantly increased catalytic activity in chemical and photocatalytic water oxidation compared to the archetype mononuclear reference [Ru(bda)(pic)2]. Kinetic investigations, including kinetic isotope effect studies, disclosed a unimolecular water nucleophilic attack mechanism of this novel dinuclear water oxidation catalyst (WOC) under the involvement of the second coordination sphere. Photocatalytic water oxidation with this cyclic dinuclear Ru complex using [Ru(bpy)3]Cl2 as a standard photosensitizer revealed a turnover frequency of 15.5 s−1 and a turnover number of 460. This so far highest photocatalytic performance reported for a Ru(bda) complex underlines the potential of this water‐soluble WOC for artificial photosynthesis.
Chiral single‐walled carbon nanotubes as chiral selectors in multimode enantioselective sensors
Authors: Stefan‐van Staden Raluca‐Ioana , Comnea‐Stancu Ionela Raluca 
Published: November 2020

AbstractSingle‐walled carbon nanotube‐(7,6) chirality was used for the design of multimode enantioselective sensors using different carbon matrices such as graphene paste, graphite paste, and carbon nanopowder‐based paste. l‐ and d‐malic acids were used as model analytes. The responses of the multimode sensors were evaluated for potentiometric and differential pulse voltammetry (DPV) modes. When carbon nanopowder was used as matrix, the multimode sensor was enantioselective for d‐malic acid in the concentration range 10−3 to 10−15 mol/L for the potentiometric mode and 10−5 to 10−8 mol/L for the DPV mode. The graphite paste‐based sensor was enantioselective for l‐malic acid in the ranges: 10−10 to 10−13 for the potentiometric mode and 10−4 to 10−7 mol/L for the DPV mode. The sensors based on graphene and chiral single‐walled carbon nanotubes were enantioselective for d‐malic acid, and a response was obtained only in the DPV mode. Accordingly, the matrix influenced both the enantioselectivity and the sensitivity of the measurements. The application of the sensors was for the enantioanalysis of malic acid in wines and apple juice samples. The proposed method is fast and reliable and allows the quantification of l‐ and d‐malic acids using electrochemical methods based on different principles, from the real samples after a buffering of the samples. The enantioanalysis of malic acid in wine and juice samples was performed with high recoveries (higher than 90.00%) and low relative standard deviation (RSD) (%) values (lower than 1.00%).
Spatial Evolution of CO2‐Contaminated Water Bubble Flows in a Vertical Pipe
Authors: Sa'adiyah Devy Setiorini , Hayashi Kosuke , Kurimoto Ryo , Tomiyama Akio 
Published: November 2020

AbstractExperiments on CO2‐water bubble flows in a vertical pipe were carried out for clean water, an aqueous NaCl solution, and an aqueous NaCl solution with 1‐octanol to obtain databases of spatial evolutions of the flows with the impurities. Mass transfer correlations for bubbles in these liquids were implemented into a one‐way bubble tracking method. Numerical predictions of the spatial evolution, e.g., transition from a bubbly to a slug flow, depending on the impurities agreed well with the experiments.