bluuebunny/crossref_metadata_2025_split huggingface dataset:
Individual- and Household-Level Interventions to Reduce Air Pollution Exposures and Health Risks: a Review of the Recent Literature
Authors: Allen Ryan W. , Barn Prabjit 
Published: November 2020

Abstract
Purpose of Review
We reviewed recent peer-reviewed literature on three categories of individual- and household-level interventions against air pollution: air purifiers, facemasks, and behavior change.

Recent Findings
High-efficiency particulate air/arresting (HEPA) filter air purifier use over days to weeks can substantially reduce fine particulate matter (PM2.5) concentrations indoors and improve subclinical cardiopulmonary health. Modeling studies suggest that the population-level benefits of HEPA filter air purification would often exceed costs. Well-fitting N95 and equivalent respirators can reduce PM2.5 exposure, with several randomized crossover studies also reporting improvements in subclinical cardiovascular health. The health benefits of other types of face coverings have not been tested and their effectiveness in reducing exposure is highly variable, depends largely on fit, and is unrelated to cost. Behavior modifications may reduce exposure, but there has been little research on health impacts.

Summary
There is now substantial evidence that HEPA filter air purifiers reduce indoor PM2.5 concentrations and improve subclinical health indicators. As a result, their use is being recommended by a growing number of government and public health organizations. Several studies have also reported subclinical cardiovascular health benefits from well-fitting respirators, while evidence of health benefits from other types of facemasks and behavior changes remains very limited. In situations when emissions cannot be controlled at the source, such as during forest fires, individual- or household-level interventions may be the primary option. In most cases, however, such interventions should be supplemental to emission reduction efforts that benefit entire communities.
Headache as a Prognostic Factor for COVID-19. Time to Re-evaluate
Authors: Martelletti Paolo , Bentivegna Enrico , Luciani Michelangelo , Spuntarelli Valerio 
Published: November 2020

AbstractHeadache occurs in only about 13% of patients within the cohort of presenting COVID-19 symptoms. The hypothesis that such a painful symptomatic picture could be considered a prognostic factor for COVID-19 positive evolution or its trend of severity, or the co-generation of hyposmia/anosmia and/or hypogeusia/ageusia, needs robust epidemiological data, punctual pathophysiological demonstrations, and a detailed comparative analysis on drug–drug interactions (DDIs).
Reluctant Reception
Authors: Norman Kelsey P. 
Published: November 2020

Seeking to understand why host states treat migrants and refugees inclusively, exclusively, or without any direct engagement, Kelsey P. Norman offers this original, comparative analysis of the politics of asylum seeking and migration in the Middle East and North Africa. While current classifications of migrant and refugee engagement in the Global South mistake the absence of formal policy and law for neglect, Reluctant Reception proposes the concept of 'strategic indifference', where states proclaim to be indifferent toward migrants and refugees, thereby inviting international organizations and local NGOs to step in and provide services on the state's behalf. Using the cases of Egypt, Morocco and Turkey to develop her theory of 'strategic indifference', Norman demonstrates how, by allowing migrants and refugees to integrate locally into large informal economies, and by allowing organizations to provide basic services, host countries receive international credibility while only exerting minimal state resources.
Migration-induced transfers of norms: the case of female political empowerment
Authors: Lodigiani Elisabetta , Salomone Sara 
Published: November 2020

AbstractThis paper empirically investigates the effect of transnational migrants on gender equality in the country of origin measured by the share of women enrolled in the lower chamber of National Parliaments. We test for a “migration-induced transfer of norm” using panel data from 1970 to 2010 in 10-year intervals. Total international migration has a positive and significant effect on female political empowerment in countries of origin conditional on the initial female parliamentary participation in both origin and destination countries. Endogeneity issues are taken into account and results are tested under specific geo-political subsamples.
Heterochronic origin of spherical fusulinid foraminifera in the late Paleozoic
Authors: Shi Yukun 
Published: November 2020

AbstractHeterochrony describes acceleration, displacement, and/or retardation of descendants’ development events compared with ancestral states and has often been cited as an important process to bring about morphological novelty. It was coined one-and-a-half centuries ago and has been discussed by both paleobiologists and biologists frequently ever since. Many types of fossil organisms preserve aspects of their development histories in their bones or shells that have been used for heterochrony analyses, with body size being used as a developmental age indicator, despite questions being raised regarding this practice. For organisms whose hard structures consist of multiple chambers, or that contain growth lines, age information suggested by these structures independently can facilitate ontogenetic modeling. In this way, relations among size, shape, and age can be established to document patterns of morphological development.Morphological analysis of pseudoschwagerine fusulinids, a fossil foraminifera group that developed a morphologically novel spherical shell, along with their presumptive triticitid ancestors illustrates this approach to heterochrony analysis. Ontogenetic trajectory comparisons of four major pseudoschwagerine genera, as well as those of triticitids, document relations between their shapes, sizes, and developmental ages. A complex of heterochronic patterns, including peramorphic predisplacement, hypermorphosis, and acceleration, characterize pseudoschwagerine development and appear to be responsible for the novel appearance of large, inflated fusiform and spherical tests in these late Paleozoic benthic foraminifera. The morphometric approach employed in this investigation could be applied widely in the quantitative morphological studies of development histories in a variety of other fossil groups.
REPATRIATION OF FAMILY MEMBERS OF FOREIGN FIGHTERS: INDIVIDUAL RIGHT OR STATE PREROGATIVE?
Authors: Spadaro Alessandra 
Published: November 2020

AbstractThis article analyses the decisions of Belgian and Dutch courts concerning the repatriation of the family members of foreign fighters who are now detained in dire conditions in North-East Syria. The article shows that, under international law, these women and children have no individual right to be repatriated by their State of nationality, based on either consular assistance, the extraterritorial applicability of human rights treaties, or the right of return to one's own country. Nonetheless there are good reasons why States should exercise their prerogative to repatriate.
Moment Risk Premia and Stock Return Predictability
Authors: Fan Zhenzhen , Xiao Xiao , Zhou Hao 
Published: November 2020

AbstractWe study the predictive power of option-implied moment risk premia embedded in the conventional variance risk premium. We find that although the second-moment risk premium predicts market returns in short horizons with positive coefficients, the third-moment (fourth-moment) risk premium predicts market returns in medium horizons with negative (positive) coefficients. Combining the higher-moment risk premia with the second-moment risk premium improves the stock return predictability over multiple horizons, both in sample and out of sample. The finding is economically significant in an asset-allocation exercise and survives a series of robustness checks.
Dosimetric comparison of different radiotherapy techniques for the treatment of Retinoblastoma
Authors: Nath Jyotiman , Goswami Pranjal , Medhi Partha Pratim , Sarma Gautam , Kalita Apurba Kumar , Bhattacharyya Mouchumee 
Published: November 2020

AbstractAim:This study aims to compare the dosimetric parameters among four different external beam radiotherapy techniques used for the treatment of retinoblastoma.Materials and methods:Computed tomography (CT) sets of five retinoblastoma patients who required radiotherapy to one globe were included. Four different plans were generated for each patient using three dimensional conformal radiotherapy (3DCRT), intensity modulated radiotherapy (IMRT), volumetric modulated arc therapy (VMAT) and VMAT using flattening filter free (VMAT-FFF) beam techniques. Plans were compared for target coverage and organs at risk (OARs) sparing.Results:The target coverage of planning target volume (PTV) for all the four modalities were clinically acceptable with a V95 of 95 ± 0%, 97·6 ± 1·87%, 99·3 ± 0·5% and 99·17 ± 0·45% for 3DCRT, IMRT, VMAT and VMAT-FFF respectively. The VMAT and IMRT plans had better target coverage than the 3DCRT plans (p = 0·001 and p = 0·07 respectively). IMRT and VMAT plans were also found superior to 3DCRT plans in terms of OAR sparing like brainstem, optic chiasm, brain (p < 0·05). VMAT delivered significantly lower dose to the brainstem and contralateral optic nerve in comparison to IMRT. Use of VMAT-FFF beams did not show any benefit over VMAT in target coverage and OAR sparing.Conclusion:VMAT should be preferred over 3DCRT and IMRT for treatment of retinoblastoma owing to better target coverage and less dose to most of the OARs. However, IMRT and VMAT should be used with caution because of the increased low dose volumes to the OARs like contralateral lens and eyeball.
Wind and Sand Transport Across a Vegetated Foredune Slope
Authors: Schwarz C. , van Starrenburg C. , Donker J. , Ruessink G. 
Published: November 2020

AbstractVegetated foredunes are widespread aeolian landforms along wave‐dominated sandy coasts. In contrast to previous advances in dune erosion during storm surges, there is a little empirical data and understanding of aeolian processes during foredune recovery and growth. Based on a comprehensive data set (airflow, sand transport, topography change, and vegetation cover) collected across a steep (1:2.5, 21.8°), high (20 m) foredune during a windy 5‐week period at Egmond aan Zee, the Netherlands, we demonstrate in agreement with previous studies that shore‐perpendicular winds accelerate by a factor of 3 from dune foot to crest but result in low aeolian mass fluxes that are maximum at the dunefoot, favoring local deposition. In contrast, oblique and alongshore winds up the foredune are accelerated less (or even decelerate) but are important in bringing sand from the dunefoot on to the foredune slope, where it is deposited when vegetation cover exceeds about 50% of the maximum density measured on the dune crest. Moreover, our data suggest that sediment flux at the dune foot is limited by fetch‐induced sediment availability, whereas sediment flux at the dune crest is limited by transport capacity, which depends on the wind velocity and the distance traveled over vegetation. Our study thus highlights the importance of wind direction and vegetation cover to foredune growth and recovery.
Antibacterial effects of platelet-rich fibrin produced by horizontal centrifugation
Authors: Feng Mengge , Wang Yulan , Zhang Peng , Zhao Qin , Yu Shimin , Shen Kailun , Miron Richard J. , Zhang Yufeng 
Published: November 2020

AbstractPlatelet-rich fibrin (PRF) has been widely used owing to its ability to stimulate tissue regeneration. To date, few studies have described the antibacterial properties of PRF. Previously, PRF prepared by horizontal centrifugation (H-PRF) was shown to contain more immune cells than leukocyte- and platelet-rich fibrin (L-PRF). This study aimed to compare the antimicrobial effects of PRFs against Staphylococcus aureus and Escherichia coli in vitro and to determine whether the antibacterial effects correlated with the number of immune cells. Blood samples were obtained from eight healthy donors to prepare L-PRF and H-PRF. The sizes and weights of L-PRF and H-PRF were first evaluated, and their antibacterial effects against S. aureus and E. coli were then tested in vitro using the inhibition ring and plate-counting test methods. Flow-cytometric analysis of the cell components of L-PRF and H-PRF was also performed. No significant differences in size or weight were observed between the L-PRF and H-PRF groups. The H-PRF group contained more leukocytes than the L-PRF group. While both PRFs had notable antimicrobial activity against S. aureus and E. coli, H-PRF demonstrated a significantly better antibacterial effect than L-PRF. Furthermore, the antimicrobial ability of the PRF solid was less efficient than that of wet PRF. In conclusion, H-PRF exhibited better antibacterial activity than L-PRF, which might have been attributed to having more immune cells.
Machine learning for suicide risk prediction in children and adolescents with electronic health records
Authors: Su Chang , Aseltine Robert , Doshi Riddhi , Chen Kun , Rogers Steven C. , Wang Fei 
Published: November 2020

AbstractAccurate prediction of suicide risk among children and adolescents within an actionable time frame is an important but challenging task. Very few studies have comprehensively considered the clinical risk factors available to produce quantifiable risk scores for estimation of short- and long-term suicide risk for pediatric population. In this paper, we built machine learning models for predicting suicidal behavior among children and adolescents based on their longitudinal clinical records, and determining short- and long-term risk factors. This retrospective study used deidentified structured electronic health records (EHR) from the Connecticut Children’s Medical Center covering the period from 1 October 2011 to 30 September 2016. Clinical records of 41,721 young patients (10–18 years old) were included for analysis. Candidate predictors included demographics, diagnosis, laboratory tests, and medications. Different prediction windows ranging from 0 to 365 days were adopted. For each prediction window, candidate predictors were first screened by univariate statistical tests, and then a predictive model was built via a sequential forward feature selection procedure. We grouped the selected predictors and estimated their contributions to risk prediction at different prediction window lengths. The developed predictive models predicted suicidal behavior across all prediction windows with AUCs varying from 0.81 to 0.86. For all prediction windows, the models detected 53–62% of suicide-positive subjects with 90% specificity. The models performed better with shorter prediction windows and predictor importance varied across prediction windows, illustrating short- and long-term risks. Our findings demonstrated that routinely collected EHRs can be used to create accurate predictive models for suicide risk among children and adolescents.
Mitochondrial ROS prime the hyperglycemic shift from apoptosis to necroptosis
Authors: Deragon Matthew A. , McCaig William D. , Patel Payal S. , Haluska Robert J. , Hodges Alexa L. , Sosunov Sergey A. , Murphy Michael P. , Ten Vadim S. , LaRocca Timothy J. 
Published: November 2020

AbstractWe have previously identified a shift from TNF-α-induced apoptosis to necroptosis that occurs under hyperglycemic conditions. This shift involves the downregulation or silencing of caspases and concurrent upregulation of necroptotic proteins leading to activation of the necrosome. In addition, under hyperglycemic conditions in vivo, this shift in cell death mechanisms exacerbates neonatal hypoxia-ischemia (HI) brain injury. Here, we identify two major factors that drive the hyperglycemic shift to necroptosis: (1) reactive oxygen species (ROS) and (2) receptor-interacting protein kinase 1 (RIP1). ROS, including mitochondrial superoxide, led to the oxidation of RIP1, as well as formation and activation of the necrosome. Concurrently, ROS mediate a decrease in the levels and activation of executioner caspases-3, -6, and -7. Importantly, hyperglycemia and mitochondrial ROS result in the oxidation of RIP1 and loss of executioner caspases prior to death receptor engagement by TNF-α. Moreover, RIP1 partially controlled levels of mitochondrial ROS in the context of hyperglycemia. As a result of its regulation of ROS, RIP1 also regulated necrosome activation and caspase loss. Mitochondrial ROS exacerbated neonatal HI-brain injury in hyperglycemic mice, as a result of the shift from apoptosis to necroptosis.
Training confounder-free deep learning models for medical applications
Authors: Zhao Qingyu , Adeli Ehsan , Pohl Kilian M. 
Published: November 2020

AbstractThe presence of confounding effects (or biases) is one of the most critical challenges in using deep learning to advance discovery in medical imaging studies. Confounders affect the relationship between input data (e.g., brain MRIs) and output variables (e.g., diagnosis). Improper modeling of those relationships often results in spurious and biased associations. Traditional machine learning and statistical models minimize the impact of confounders by, for example, matching data sets, stratifying data, or residualizing imaging measurements. Alternative strategies are needed for state-of-the-art deep learning models that use end-to-end training to automatically extract informative features from large set of images. In this article, we introduce an end-to-end approach for deriving features invariant to confounding factors while accounting for intrinsic correlations between the confounder(s) and prediction outcome. The method does so by exploiting concepts from traditional statistical methods and recent fair machine learning schemes. We evaluate the method on predicting the diagnosis of HIV solely from Magnetic Resonance Images (MRIs), identifying morphological sex differences in adolescence from those of the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA), and determining the bone age from X-ray images of children. The results show that our method can accurately predict while reducing biases associated with confounders. The code is available at https://github.com/qingyuzhao/br-net.
β-arrestin 2 as an activator of cGAS-STING signaling and target of viral immune evasion
Authors: Zhang Yihua , Li Manman , Li Liuyan , Qian Gui , Wang Yu , Chen Zijuan , Liu Jing , Fang Chao , Huang Feng , Guo Daqiao , Zou Quanming , Chu Yiwei , Yan Dapeng 
Published: November 2020

AbstractVirus infection may induce excessive interferon (IFN) responses that can lead to host tissue injury or even death. β-arrestin 2 regulates multiple cellular events through the G protein-coupled receptor (GPCR) signaling pathways. Here we demonstrate that β-arrestin 2 also promotes virus-induced production of IFN-β and clearance of viruses in macrophages. β-arrestin 2 interacts with cyclic GMP-AMP synthase (cGAS) and increases the binding of dsDNA to cGAS to enhance cyclic GMP-AMP (cGAMP) production and the downstream stimulator of interferon genes (STING) and innate immune responses. Mechanistically, deacetylation of β-arrestin 2 at Lys171 facilitates the activation of the cGAS–STING signaling and the production of IFN-β. In vitro, viral infection induces the degradation of β-arrestin 2 to facilitate immune evasion, while a β-blocker, carvedilol, rescues β-arrestin 2 expression to maintain the antiviral immune response. Our results thus identify a viral immune-evasion pathway via the degradation of β-arrestin 2, and also hint that carvedilol, approved for treating heart failure, can potentially be repurposed as an antiviral drug candidate.
Systemic and sustained thioredoxin analogue prevents acute kidney injury and its-associated distant organ damage in renal ischemia reperfusion injury mice
Authors: Nishida Kento , Watanabe Hiroshi , Miyahisa Masako , Hiramoto Yuto , Nosaki Hiroto , Fujimura Rui , Maeda Hitoshi , Otagiri Masaki , Maruyama Toru 
Published: November 2020

AbstractThe mortality of patients with acute kidney injury (AKI) remains high due to AKI associated-lung injury. An effective strategy for preventing both AKI and AKI-associated lung injury is urgently needed. Thioredoxin-1 (Trx) is a redox-active protein that possesses anti-oxidative, anti-apoptotic and anti-inflammatory properties including modulation of macrophage migration inhibitory factor (MIF), but its short half-life limits its clinical application. Therefore, we examined the preventive effect of a long-acting Trx, which is a fusion protein of albumin and Trx (HSA-Trx), against AKI and AKI-associated lung injury. Recombinant HSA-Trx was expressed using a Pichia expression system. AKI-induced lung injury mice were generated by bilateral renal ischemia reperfusion injury (IRI). HSA-Trx administration attenuated renal IRI and its-associated lung injury. Both renal and pulmonary oxidative stress were suppressed by HSA-Trx. Moreover, HSA-Trx inhibited elevations of plasma IL-6 and TNF-α level, and suppressed IL-6–CXCL1/2-mediated neutrophil infiltration into lung and TNF-α-mediated pulmonary apoptosis. Additionally, HSA-Trx suppressed renal IRI-induced MIF expression in kidney and lung. Administration of HSA-Trx resulted in a significant increase in the survival rate of renal IRI mice. Collectively, HSA-Trx could have therapeutic utility in preventing both AKI and AKI-associated lung injury as a consequence of its systemic and sustained multiple biological action.
The importance of the surface roughness and running band area on the bottom of a stone for the curling phenomenon
Authors: Kameda Takao , Shikano Daiki , Harada Yasuhiro , Yanagi Satoshi , Sado Kimiteru 
Published: November 2020

AbstractCurling is a sport in which players deliver a cylindrical granite stone on an ice sheet in a curling hall toward a circular target located 28.35 m away. The stone gradually moves laterally, or curls, as it slides on ice. Although several papers have been published to propose a mechanism of the curling phenomenon for the last 100 years, no established theory exists on the subject, because detailed measurements on a pebbled ice surface and a curling stone sliding on ice and detailed theoretical model calculations have yet to be available. Here we show using our precise experimental data that the curl distance is primarily determined by the surface roughness and the surface area of the running band on the bottom of a stone and that the ice surface condition has smaller effects on the curl distance. We also propose a possible mechanism affecting the curling phenomena of a curing stone based on our results. We expect that our findings will form the basis of future curling theories and model calculations regarding the curling phenomenon of curling stones. Using the relation between the curl distance and the surface roughness of the running band in this study, the curl distance of a stone sliding on ice in every curling hall can be adjusted to an appropriate value by changing the surface roughness of the running band on the bottom of a stone.