bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptome analysis of messenger RNA and long noncoding RNA related to different developmental stages of tail adipose tissues of sunite sheep
Authors: He Xige , Wu Rihan , Yun Yueying , Qin Xia , Chen Lu , Han Yunfei , Wu Jindi , Sha Lina , Borjigin Gerelt 
Published: December 2020

Abstract
Background: Sunite sheep are a fat-tailed sheep species with a low percentage of intramuscular fat and good quality lean meat, and their tail fat can be used as a source of dietary fat by humans. To understand the potential regulatory mechanism of different growth stages of tail fat in Sunite sheep, we performed high-throughput RNA sequencing to characterize the long noncoding RNA (lncRNA) and messenger RNA (mRNA) expression profiles of the sheep tail fat at the age of 6 months, 18 months, and 30 months.Results: A total of 223 differentially expressed genes (DEGs) and 148 differentially expressed lncRNAs were found in the tail fat of 6-, 18-, and 30-month-old sheep (false discovery rate < 0.05, |Fold Change| ≥ 2). Based on the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis, we found that fat-related DEGs were mainly expressed at 6 months of age, and gradually decreased at 18 and 30 months of age. The target gene prediction analysis shows that most of the lncRNAs target more than 20 mRNAs as their trans-regulators (53 mRNAs at most). Further, we obtained several fat-related differentially-expressed target genes; these target genes interact with different differentially expressed lncRNAs at various ages and play an important role in the development of tail fat. Based on the DEGs and differentially expressed lncRNAs, we established three co-expression networks for each comparison group. Conclusions: Finally, we conclude that the development of the sheep tail fat is more active during the early stage of growth and gradually decreases with the increase in age. The mutual regulation of lncRNAs and mRNAs may play a key role in this complex biological process, and our findings will provide some basic theoretical data for future studies on tail fat development of fat-tailed sheep.
Cross-Study Analyses of Gut Microbiomes from Healthy and Obese Individuals
Authors: Deraspe Maxime , Burdet Charles , Dominguez Juan Manuel , Laviolette François , Roy Paul H , Corbeil Jacques 
Published: December 2020

Abstract
Background: With the advent of metagenomics, many large studies have been conducted with the quest of better understanding gut microbiota changes in relation to varying health conditions. Significant findings have been made for diseases such as cirrhosis, colorectal cancers, inflammatory bowel diseases and others, yet one that stands out is obesity for which conflicting results have been reported in the literature. Methods: Here, we built and analyzed a cross-study dataset of healthy and obese individuals looking for major changes in the the taxonomic and functional composition of their metagenomes. Results: Our results suggest that the overweight and normal subjects have no strong dissimilarity in their metagenomes composition. Significant differences were observed when comparing the obese and the non-obese individuals in their functional and taxonomic profiles. Conclusion: In this study, we report the most significant changes that we observed and discuss their potential implication in the obesity condition.
Piezoelectric Properties of PVDF Modified 3-3 Type Cement-Based Piezoelectric Composites
Authors: Liu Wei , zhang lehui , Cao Yu , Wang Jianhong , Bai Peikang , Yang Jinlong 
Published: December 2020

Abstract
In this study, 3-3 type cement-based piezoelectric composites were prepared by casting Portland cement paste in porous lead zirconate titanate (PZT) ceramics, then the Polyvinylidene fluoride (PVDF) of N-Methylpyrrolidone (NMP) solvent with concentration of 50-200 mg/ml was utilized to modify the PZT-PC composites. The influence of PVDF concentration on the density, microstructure, dielectric, piezoelectric and electromechanical properties were investigated. The results indicate that the density of PZT-PC composites increased gradually with PVDF concentration for the increasing combined weight of PVDF with the composites. The introduction of PVDF has also contributed to the reduction of leakage current during the poling and testing process, which led to increased relative permittivity εr and longitudinal piezoelectric strain coefficient d33, while the dielectric loss tanδ and longitudinal piezoelectric voltage coefficient g33 demonstrated an opposite changing trend. Both the thickness electromechanical coupling coefficient Kt and planar electromechanical coupling coefficient Kp of the PZT-PC composites increased with PVDF concentration. The acoustic impedance (Z) of PVDF modified PZT-PC composites ranged from 6.89 to 7.65 MRayls, making it suitable for applications in the health monitoring of civil engineering.
Pneumothorax in patients with idiopathic pulmonary fibrosis: A real-world experience
Authors: Yamazaki Ryo , Nishiyama Osamu , Gose Kyuya , Saeki Sho , Sano Hiroyuki , Iwanaga Takashi , Tohda Yuji 
Published: December 2020

Abstract
Background: Some patients with idiopathic pulmonary fibrosis (IPF) develop pneumothorax. However, the characteristics of pneumothorax in patients with IPF have not been elucidated. The purpose of this study was to clarify the clinical course, actual management, and treatment outcomes of pneumothorax in patients with IPF.Methods: Consecutive patients with IPF who were admitted for pneumothorax between January 2008 and December 2018 were included. The success rates of treatment for pneumothorax, hospital mortality, and recurrence rate after discharge were examined.Results: During the study period, 36 patients with IPF were admitted with pneumothorax a total of 58 times. During the first admission, 15 patients (41.7%) did not receive chest tube drainage, but 21 (58.3%) did. Of the 21 patients, 8 (38.1%) received additional therapy after chest drainage. The respective treatment success rates were 86.6% and 66.7% in patients who underwent observation only vs chest tube drainage. The respective hospital mortality rates were 13.3% and 38.0%. The total pneumothorax recurrence rate after hospital discharge was 34.6% (n = 9).Conclusions: Pneumothorax in patients with IPF was difficult to treat successfully, had a relatively poor prognosis, and showed a high recurrence rate.
Patient satisfaction and its socio-demographic correlates in a tertiary public hospital in Nepal: A cross sectional study
Authors: Adhikari Mukesh , Poudel Narendra Raj , Mishra Shiva Raj , Shrestha Archana , Upadhyaya Dipak Prasad 
Published: December 2020

Abstract
Background Patient satisfaction is one proxy indicator of the health care quality; however, enhancing patient satisfaction in low-income settings is very challenging due to the inadequacy of resources as well as low health literacy among patients. In this study, we assess patient satisfaction and its correlates in a tertiary public hospital in Nepal.Methods We conducted a cross sectional study at outpatient department of Bhaktapur Hospital of Nepal. To recruit participants for the study, we applied a systematic random sampling method. Our study used a validated Patient Satisfaction Questionnaire III (PSQ-III) developed by RAND Corporation including various contextual socio-demographic characteristics. We calculated mean score and percentages of satisfaction across seven dimensions of patient satisfaction. To determine the association between various dimensions of patient satisfaction and socio-demographic characteristics of the patient, we used a multi-ordinal logistic regression.Results Among 204 patients, we observed a wide variation in patient satisfaction across seven dimensions. About 39 % of patients were satisfied in the dimension of general satisfaction, 92 % in interpersonal manner, and 45 % in accessibility and convenience. Sociodemographic factors such as age (AOR: 6.42; CI: 1.30-35.05), gender (AOR: 2.81; CI: 1.41-5.74), and ethnicity (AOR: 0.26; CI: 0.08-0.77) were associated with general satisfaction of the patients. Other sociodemographic variables such as education, occupation, and religion were associated with a majority of the dimensions of patient satisfaction (p <0.05). Age was found to be the strongest predictor of patient satisfaction in five out of seven dimensions.Conclusions We concluded that patient satisfaction varies across different dimensions. Therefore, targeted interventions that direct to improve the dimensions of patient satisfaction where the proportion of satisfaction is low are needed. Similar studies should be conducted regularly at different levels of health facilities across the country to capture a wider picture of patient satisfaction at various levels.
Doping Practices in International Weightlifting: Analysis of sanctioned athletes/support personnel from 2008-2019 and retesting of samples from the 2008 and 2012 Olympic Games
Authors: Kolliari-Turner Alexander , Oliver Brian , Lima Giscard , Mills John P. , Wang Guan , Pitsiladis Yannis , Guppy Fergus M 
Published: December 2020

Abstract
Background: The pervasiveness of doping and findings of anti-doping corruption threaten weightlifting’s position at the 2024 Olympic Games. Analysing the practices of doping in weightlifters could identify patterns in doping that assist in future detection. Methods: We analysed publicly available data on sanctioned athletes/support personnel from the International Weightlifting Federation between 2008-2019 and announced retrospective Anti-Doping Rule Violations (ADRVs) from the 2008 and 2012 Olympic Games. Results: There were 565 sanctions between 2008-2019 of which 82% related to the detection of exogenous Anabolic Androgenic Steroid (AAS) metabolites and markers indicating endogenous AAS usage. The detection of exogenous AAS metabolites, markers of endogenous AAS usage and other substance metabolites varied by IWF Continental Federation (p ≤ 0.05) with Europe (74%, 11%, 15%) and Asia (70%, 15%, 15%) showing a higher detection of exogenous AAS compared to Pan America (37%, 30%, 33%) and Africa (50%, 17%, 33%). When looking at the 10 most detected substances, the nations with the highest number of sanctions (range 17-35) all had at least one overrepresented substance that accounted for 38-60% of all detected substances. The targeted re-analysis of samples from the 2008 and 2012 Olympic Games due to the discovery of long-term metabolites for exogenous AAS resulted in 61 weightlifters producing retrospective ADRVs. This includes 34 original medallists (9 Gold, 10 Silver and 15 Bronze), the highest of any sport identified by Olympic Games sample re-testing. The exogenous AAS Dehydrochloromethyltestosterone and Stanozolol accounted for 83% of detected substances and were present in 95% of these samples. Conclusion: Based on these findings of regional differences in doping practices, weightlifting would benefit from the targeted testing of certain regions and continuing investment in long-term sample storage as the sensitivity and specificity of detection continues to improve.
El rol del maestro en indagaciones escolares mediante simulaciones
Authors: Solé-Llussà Anna , Aguilar Caamaño David , Ibáñez Plana Manuel 
Published: December 2020

En la didáctica de las ciencias experimentales las simulaciones mediante ordenador permiten a los estudiantes de primaria indagar fenómenos naturales sobre los que difícilmente podrían experimentar manipulativamente. Las simulaciones ayudan a mejorar el aprendizaje de los estudiantes, pero la mayor parte de la literatura sobre simulaciones no considera el papel de los maestros en estas indagaciones con experimentación virtual. Este trabajo de revisión sintetiza los principales resultados prácticos ofrecidos por las 8 investigaciones disponibles en la literatura. Todos ellos basados en simulaciones libremente disponibles en las plataformas PhET Simulations y Concorde Consortium.
La revisión concluye que faltan estudios integrados en su contexto curricular y estudios comparativos, en cuanto al papel del maestro, entre indagaciones tradicionales y mediante simulación. Finalmente se sugiere la oportunidad de desarrollar una biblioteca organizada y completa de simulaciones indagadoras para educación primaria.
Entornos tecnológicos en el codiseño de itinerarios personalizados de aprendizaje en la enseñanza superior
Authors: De Benito Bárbara , Moreno García Juan , Villatoro Moral Sofía 
Published: December 2020

Las tendencias metodológicas en la educación superior, basadas en la flexibilización y la participación activa de los estudiantes, requieren nuevas configuraciones tecnológicas que faciliten su implementación.
En este artículo, se presenta un estudio dirigido a analizar las herramientas y funciones asociadas a los procesos de codiseño, enfocados a la construcción de itinerarios personalizados de aprendizaje en entornos virtuales en el ámbito universitario.
Siguiendo una metodología de Investigación Basada en Diseño, el estudio se ha realizado en seis asignaturas de tecnología educativa en los grados de Educación Infantil, Primaria y Pedagogía de la Universidad de las Islas Baleares.
Como resultado, se ha generado una clasificación funcional de herramientas, que ha permitido elaborar una propuesta de configuración de entorno tecnológico de apoyo a procesos para codiseño en la construcción de itinerarios de aprendizaje que favorezcan la autorregulación y la agencia de los estudiantes.
Cualquier propuesta de configuración tecnológica debe responder al diseño pedagógico, decisiones institucionales, logísticas o personales.
Virus as a Nanocarrier for Drug Delivery Redefining Medical
Therapeutics - A Status Report
Authors: Ojha Sanjay Kumar , Kumar Subrat , Pattnaik Ritesh , Singh Puneet Kumar , Dixit Shubha , Mishra Snehasish , Pal Sreyasi 
Published: December 2020

:
Over the last two decades, drug delivery systems have evolved at a tremendous rate. Synthetic nanoparticles have
played an important role in the design of vaccine and their delivery as many of them have shown improved safety and
efficacy over conventional formulations. Nanocarriers formulated by natural, biological building blocks have become an
important tool in the field biomedicine. A successful nanocarrier must have certain properties like evading the host immune
system, target specificity, cellular entry, escape from endosomes, and ability to release material into the cytoplasm. Some or
all of these functions can be performed by viruses making them a suitable candidate for naturally occurring nanocarriers.
Moreover, viruses can be made non-infectious and non-replicative without compromising their ability to penetrate cells thus
making them useful for a vast spectrum of applications. Currently, various carrier molecules are under different stages of
development to become bio-nano capsules. This review covers the advances made in the field of viruses as potential
nanocarriers and discusses the related technologies and strategies to target specific cells by using virus inspired nanocarriers.
In future, these virus-based nano-formulations will be able to provide solutions towards pressing and emerging infectious
diseases.
Framing Effect And Belief Adjustment Model In Investment Judgment
Authors: Almilia Luciana Spica , Wulanditya Putri , Nita Riski Aprilia 
Published: December 2020

This study aims to examine the framing effect and belief adjustment model of the investment decision. A previous study examined partially the effect of framing and belief adjustment models. This research used experiment method. Research method is 2 x 2 x 2 mixed design experiment (between and within subject). Experiment method of 2 x 2 x 2 includes disclosure pattern (step by step and end of sequence), evidence order (good news followed by bad news and bad news followed by good news), and Framing Effect (negative frame and positive frame). Research participants in this research are: non-professional investor and professional investor. The number of participants in this research is 274 people consisting of 154 participants from non-professional investors and 120 participants from professional investors. The experiment was done by researcher in June to October 2015. The results showed framing effect, the order of presentation and the presentation of information patterns affect investors in making investment decisions. The contribution for financial accountancy literature is that this research tries to conduct reconstruction on puzzle of investment decision making model.
Conteúdo iônico em um testemunho de firn do Platô Antártico
Authors: GERHARD Nicoli P. , SIMÕES Jefferson C. , THOEN Isaías U. , TAVARES Flávia A. , CASASSA Gino , BERNARDO Ronaldo T. 
Published: December 2020

Este trabalho investiga o conteúdo iônico dos 28,73 m superiores do testemunho BR-IC-2 (88°01'21,3"S; 82°04'21,7"W), coletado durante a travessia antártica chileno-brasileira no verão austral de 2004/05. As concentrações dos íons majoritários Na+, K+, Mg2+, Ca2+, Cl-, NO3- e SO42- e do ácido orgânico H3CSO3- (metanosulfonato - MS-) foram determinadas por cromatografia iônica. A datação, baseada na correlação entre as concentrações de Na+ e nssSO42- (sulfato não proveniente de sal marinho), na razão isotópica δD e na identificação de sinais de erupções vulcânicas (Pinatubo / Cerro Hudson em 1993, Agung em 1965 e possivelmente Bristol Island em 1936) constatou uma idade de 85 anos (período 1918–2003) para o testemunho, com precisão de ± 3 anos. A partir da datação foi possível estabelecer a precipitação anual média nesse sítio: 0,15 m eq H2O. Constatou-se uma contribuição de aerossóis de sais marinhos pouco expressiva e uma grande contribuição crustal e biogênica, indicada pelas concentrações de nssCa2+ e nssSO42, respectivamente. O alto valor da razão Cl-/Na+ (4,96) indica que outros fatores, além da contribuição de sal marinho, contribuem para as concentrações desses íons, como a entrada ou formação de HCl e a menor depleção do Cl-. As concentrações de K+ e Mg2+, apesar de apresentarem correlação fraca com os outros íons, são de origem marinha. O MS- mostra valores pouco expressivos para a região e o NO3- não tem correlação com os outros íons, devido à complexidade das fontes, já que este íon se apresenta como um aerossol secundário.
Expanding the Meaning of the Term “Document” as a Possible Factor of Reconsideration of the Objects of Bibliometrics, Scientometrics, and Informetrics. 2. Old Definitions of the Objects of “Metrices” in the Context of the New Definition of the Term “Document”
Authors: Lazarev V. S. 
Published: December 2020

Introduction. In the first part of the article, an attempt was made to trace some of the evolution of the concept of a “document”, which is now understood as any material object that can be used to obtain the information necessary for a person. In the second part, assuming that such an interpretation of the concept of a “document” is fruitful for possible reconsideration of viewpoints on the objects of bibliometrics, scientometrics and informetrics, a number of definitions of the objects of these three “metrices” have been examined with a speculative “inlining” the new meaning of the term “document” to the definitions of objects.Materials and methods. Comparative analysis of the viewpoints of the objects of bibliometrics, scientometrics and informetrics that were expressed in some examples of definitions of these scientific fields; speculative “inlining” the new meaning of the term “document” in them; consideration the meanings of the objects of “metrices” altered as a result of the mentioned “inlining”.Results. It is shown how noticeably the understanding of the objects of bibliometrics, scientometrics and informetrics can be revised as the result of the use of the updated “broad” interpretation of the concept of a “document” and how much the interpretations of the objects of bibliometrics, scientometrics and informetrics can be even closer in their meanings than previously was recognized.Discussion and conclusion. Such a comparative analysis of the objects of the “metrices” might be helpful for identifying both similarities and differences among bibliometrics, scientometrics and informetrics. This is important, since the awareness of them is an obvious starting point for the mutual enrichment of “metrices” with knowledge and concepts. A more complete and detailed analysis of representations of the objects of the “metrices” in comparison with the updated “broad” interpretation of the concept of the “document”, as well as a comparison of the methodological components of “metrices” is the subject of further research.
RENCANA SABUK HIJAU TIMUR KOTABARU KEBAYORAN: KEBIJAKAN SETENGAH HATI? STUDI TENTANG TRANSFORMASI KAWASAN
Authors: Claudio Glen , Fahmi Erwin 
Published: December 2020

Kebayoran new city was the first satellite city planned on the outskirts of post-world war II Jakarta. By applying the garden city concept, Kebayoran new city was planned to have green belt elements in the west and east to limit its growth. Along with the rapid development of the main axis of the City of Jakarta (Jl. Thamrin - Jl. Sudirman) after the transfer of sovereignty (1949) and the expansion of the administrative boundaries of the City of Jakarta, the newcity of Kebayoran has undergone a transformation and changes / adjustments to plans. One of the consequences, Kebayoran new city is no longer a satellite city as originally planned. The idea of a green belt in the eastern part also did not materialize as it should. This study aims to identify the enforcing and enabling factors for not realizing the idea of the eastern green belt of Kebayoran new city. The method used is a qualitative method with a case study approach. The research findings indicate that the enforcing factor for this failure is mainly government (central and regional) development policies after the transfer of sovereignty. Enabling factors are the fact that some parts of the area have not been acquired, and local government policies that allow or develop parts of the area for other functions. By knowing the enforcing and enabling factors above, this research is expected to be a lesson for planners and policy makers for the development of new cities in the future. Keywords: government policies; green belt; Kebayoran Baru; urban transformation ABSTRAKKota baru Kebayoran merupakan kota satelit pertama yang direncanakan di pinggiran Jakarta pasca kemerdekaan. Dengan menerapkan konsep garden city, kota baru Kebayoran direncanakan memiliki elemen sabuk hijau di bagian Barat dan Timur untuk membatasi pertumbuhannya. Seiring dengan perkembangan pesat poros utama Kota Jakarta (Jl. Thamrin – Jl. Sudirman) pasca penyerahan kedaulatan (1949) dan meluasnya batas administratif Kota Jakarta, kota baru Kebayoran mengalami transformasi dan perubahan/penyesuaian rencana. Salah satu akibatnya, kota baru Kebayoran tidak lagi menjadi kota satelit seperti rencana awal. Gagasan sabuk hijau pada bagian Timur juga tidak terwujud sebagaimana mestinya. Penelitian ini bertujuan mengidentifikasi faktor pendorong dan faktor pemungkin tidak terwujudnya gagasan sabuk hijau Timur kota baru Kebayoran. Metode yang digunakan adalah metode kualitatif dengan pendekatan studi kasus. Temuan penelitian menunjukkan bahwa faktor pendorong kegagalan tersebut terutama adalah kebijakan pembangunan pemerintah (Pusat dan Daerah) pasca penyerahan kedaulatan tersebut. Faktor pemungkin adalah kenyataan bahwa beberapa bagian kawasan belum diakuisisi, dan kebijakan pemerintah daerah yang mengijinkan atau mengembangkan bagian kawasan untuk fungsi lain. Dengan mengetahui faktor pendorong dan faktor pemungkin di atas, penelitian ini diharapkan dapat menjadi pembelajaran bagi perencana dan pembuat kebijakan pembangunan kota baru di masa mendatang.