bluuebunny/crossref_metadata_2025_split huggingface dataset:
Burden of respiratory syncytial virus hospitalisation among infants born at 32–35 weeks' gestational age in the Northern Hemisphere: pooled analysis of seven studies
Authors: Lanari M. , Anderson E.J. , Sheridan-Pereira M. , Carbonell-Estrany X. , Paes B. , Rodgers-Gray B.S. , Fullarton J. R. , Grubb E. , Blanken M. 
Published: August 2020

AbstractTo provide comprehensive information on the epidemiology and burden of respiratory syncytial virus hospitalisation (RSVH) in preterm infants, a pooled analysis was undertaken of seven multicentre, prospective, observational studies from across the Northern Hemisphere (2000–2014). Data from all 320–356weeks' gestational age (wGA) infants without comorbidity were analysed. RSVH occurred in 534/14 504 (3.7%) infants; equating to a rate of 5.65per100 patient-seasons, with the rate in individual wGA groups dependent upon exposure time (P= 0.032). Most RSVHs (60.1%) occurred in December–January. Median age at RSVH was 88 days (interquartile range (IQR): 54–159). Respiratory support was required by 82.0% of infants: oxygen in 70.4% (median 4 (IQR: 2–6) days); non-invasive ventilation in 19.3% (median 3 (IQR: 2–5) days); and mechanical ventilation in 10.2% (median 5 (IQR: 3–7) days). Intensive care unit admission was required by 17.9% of infants (median 6 days (IQR: 2–8) days). Median overall hospital length of stay (LOS) was 5 (IQR: 3–8) days. Hospital resource use was similar across wGA groups except for overall LOS, which was shortest in those born 35 wGA (median 3vs.4–6 days for 32–34 wGA;P< 0.001). Strategies to reduce the burden of RSVH in otherwise healthy 32–35 wGA infants are indicated.
PROJECTIVE LOOPS GENERATE RATIONAL LOOP GROUPS
Authors: Wang Gang , Goertsches Oliver , Wang Erxiao 
Published: August 2020

AbstractWe generalize Uhlenbeck’s generator theorem of ${\mathcal{L}}^{-}\operatorname{U}_{n}$ to the full rational loop group ${\mathcal{L}}^{-}\operatorname{GL}_{n}\mathbb{C}$ and its subgroups ${\mathcal{L}}^{-}\operatorname{GL}_{n}\mathbb{R}$, ${\mathcal{L}}^{-}\operatorname{U}_{p,q}$: they are all generated by just simple projective loops. Recall that Terng–Uhlenbeck studied the dressing actions of such projective loops as generalized Bäcklund transformations for integrable systems. Our result makes a nice supplement: any rational dressing is the composition of these Bäcklund transformations. This conclusion is surprising in the sense that Lie theory suggests the indispensable role of nilpotent loops in the case of noncompact reality conditions, and nilpotent dressings appear quite complicated and mysterious. The sacrifice is to introduce some extra fake singularities. So we also propose a set of generators if fake singularities are forbidden. A very geometric and physical construction of $\operatorname{U}_{p,q}$ is obtained as a by-product, generalizing the classical construction of unitary groups.
INVARIANT HYPERSURFACES
Authors: Bell Jason , Moosa Rahim , Topaz Adam 
Published: August 2020

AbstractThe following theorem, which includes as very special cases results of Jouanolou and Hrushovski on algebraic $D$-varieties on the one hand, and of Cantat on rational dynamics on the other, is established: Working over a field of characteristic zero, suppose $\unicode[STIX]{x1D719}_{1},\unicode[STIX]{x1D719}_{2}:Z\rightarrow X$ are dominant rational maps from an (possibly nonreduced) irreducible scheme $Z$ of finite type to an algebraic variety $X$, with the property that there are infinitely many hypersurfaces on $X$ whose scheme-theoretic inverse images under $\unicode[STIX]{x1D719}_{1}$ and $\unicode[STIX]{x1D719}_{2}$ agree. Then there is a nonconstant rational function $g$ on $X$ such that $g\unicode[STIX]{x1D719}_{1}=g\unicode[STIX]{x1D719}_{2}$. In the case where $Z$ is also reduced, the scheme-theoretic inverse image can be replaced by the proper transform. A partial result is obtained in positive characteristic. Applications include an extension of the Jouanolou–Hrushovski theorem to generalised algebraic ${\mathcal{D}}$-varieties and of Cantat’s theorem to self-correspondences.
“Strange What Cosmopolites Music Makes of Us”: Classical Music, the Black Press, and Nora Douglas Holt's Black Feminist Audiotopia
Authors: CAPLAN LUCY 
Published: August 2020

AbstractThis article examines the music criticism of Nora Douglas Holt, an African American woman who wrote a classical music column for theChicago Defender(1917–1923) and published a monthly magazine,Music and Poetry(1921–1922). I make two claims regarding the force and impact of Holt's ideas. First, by writing about classical music in the black press, Holt advanced a model of embodied listening that rejected racist attempts to keep African Americans out of the concert hall and embraced a communal approach to knowledge production. Second, Holt was a black feminist intellectual who refuted dominant notions of classical music's putative race- and gender-transcending universalism; instead, she acknowledged the generative possibilities of racial difference in general and blackness in particular. I analyze Holt's intellectual commitments by situating her ideas within the context of early twentieth-century black feminist thought; analyzing the principal themes of her writing in theChicago DefenderandMusic and Poetry; and assessing her engagement with a single musical work, Tchaikovsky'sSymphony No. 4 in F Minor, op. 36.Ultimately, Holt's criticism offers new insight into how race, gender, and musical activity intersected in the Jim Crow era and invites a more nuanced and capacious understanding of black women's manifold contributions to US musical culture.
Effects of maternal low-protein diet and spontaneous physical activity on the transcription of neurotrophic factors in the placenta and the brains of mothers and offspring rats
Authors: Fragoso Jéssica , Carvalho Jurema Santos Gabriela , da Silva Helyson Thomaz , Loizon Emmanuelle , de Oliveira Nogueira Souza Viviane , Vidal Hubert , Guedes Rubem Carlos Araújo , Costa-Silva João Henrique , da Silva Aragão Raquel , Pirola Luciano , Leandro Carol Gois 
Published: August 2020

AbstractMaternal protein restriction and physical activity can affect the interaction mother–placenta–fetus. This study quantified the gene expression of brain-derived neurotrophic factor (BDNF), neurothrophin 4, tyrosine kinase receptor B (TrkB/NTRK2), insulin-like growth factor (IGF-1), and insulin-like growth factor receptor (IGF-1r) in the different areas of mother’s brain (hypothalamus, hippocampus, and cortex), placenta, and fetus’ brain of rats. Female Wistar rats (n = 20) were housed in cages containing a running wheel for 4 weeks before gestation. According to the distance spontaneously traveled daily, rats were classified as inactive or active. During gestation, on continued access to the running wheel, active and inactive groups were randomized to receive normoprotein diet (18% protein) or a low-protein (LP) diet (8% protein). At day 20 of gestation, gene expression of neurotrophic factors was analyzed by quantitative polymerase chain reaction in different brain areas and the placenta. Dams submitted to a LP diet during gestation showed upregulation of IGF-1r and BDNF messenger RNA in the hypothalamus, IGF-1r and NTRK2 in the hippocampus, and BDNF, NTRK2, IGF-1 and IGF-1r in the cortex. In the placenta, there was a downregulation of IGF-1. In the brain of pups from mothers on LP diet, IGF-1r and NTRK2 were downregulated. Voluntary physical activity attenuated the effects of LP diet on IGF-1r in the hypothalamus, IGF-1r and NTRK2 in the hippocampus, IGF-1 in the placenta, and NTRK2 in the fetus’ brain. In conclusion, both maternal protein restriction and spontaneous physical activity influence the gene expression of BDNF, NTRK2, IGF-1, and IGF-1r, with spontaneous physical activity being able to normalize in part the defects caused by protein restriction during pregnancy.
Advances in the field of intranasal oxytocin research: lessons learned and future directions for clinical research
Authors: Quintana Daniel S. , Lischke Alexander , Grace Sally , Scheele Dirk , Ma Yina , Becker Benjamin 
Published: August 2020

AbstractReports on the modulatory role of the neuropeptide oxytocin on social cognition and behavior have steadily increased over the last two decades, stimulating considerable interest in its psychiatric application. Basic and clinical research in humans primarily employs intranasal application protocols. This approach assumes that intranasal administration increases oxytocin levels in the central nervous system via a direct nose-to-brain route, which in turn acts upon centrally-located oxytocin receptors to exert its behavioral effects. However, debates have emerged on whether intranasally administered oxytocin enters the brain via the nose-to-brain route and whether this route leads to functionally relevant increases in central oxytocin levels. In this review we outline recent advances from human and animal research that provide converging evidence for functionally relevant effects of the intranasal oxytocin administration route, suggesting that direct nose-to-brain delivery underlies the behavioral effects of oxytocin on social cognition and behavior. Moreover, advances in previously debated methodological issues, such as pre-registration, reproducibility, statistical power, interpretation of non-significant results, dosage, and sex differences are discussed and integrated with suggestions for the next steps in translating intranasal oxytocin into psychiatric applications.
Polygenic risk score analysis revealed shared genetic background in attention deficit hyperactivity disorder and narcolepsy
Authors: Takahashi Nagahide , Nishimura Tomoko , Harada Taeko , Okumura Akemi , Choi Damee , Iwabuchi Toshiki , Kuwabara Hitoshi , Takagai Shu , Nomura Yoko , Newcorn Jeffrey. H. , Takei Nori , Tsuchiya Kenji J. 
Published: August 2020

AbstractAttention deficit hyperactive disorder (ADHD) is a highly heritable neurodevelopmental disorder, and excessive daytime sleepiness is frequently observed in ADHD patients. Excessive daytime sleepiness is also a core symptom of narcolepsy and essential hypersomnia (EHS), which are also heritable conditions. Psychostimulants are effective for the symptomatic control of ADHD (primary recommended intervention) and the two sleep disorders (frequent off-label use). However, the common biological mechanism for these disorders has not been well understood. Using a previously collected genome-wide association study of narcolepsy and EHS, we calculated polygenic risk scores (PRS) for each individual. We investigated a possible genetic association between ADHD and narcolepsy traits in the Hamamatsu Birth Cohort for mothers and children (HBC study) (n = 876). Gene-set enrichment analyses were used to identify common pathways underlying these disorders. Narcolepsy PRS were significantly associated with ADHD traits both in the hyperactivity domain (e.g., P-value threshold < 0.05, β [SE], 5.815 [1.774]; P = 0.002) and inattention domain (e.g., P-value threshold < 0.05, β [SE], 5.734 [1.761]; P = 0.004). However, EHS PRS was not significantly associated with either domain of ADHD traits. Gene-set enrichment analyses revealed that pathways related to dopaminergic signaling, immune systems, iron metabolism, and glial cell function involved in both ADHD and narcolepsy. Findings indicate that ADHD and narcolepsy are genetically related, and there are possible common underlying biological mechanisms for this relationship. Future studies replicating these findings would be warranted to elucidate the genetic vulnerability for daytime sleepiness in individuals with ADHD.
Sodium/potassium ratio change was associated with blood pressure change: possibility of population approach for sodium/potassium ratio reduction in health checkup
Authors: Kogure Mana , Nakaya Naoki , Hirata Takumi , Tsuchiya Naho , Nakamura Tomohiro , Narita Akira , Suto Yoko , Honma Yoko , Sasaki Hidemi , Miyagawa Ken , Ushida Yusuke , Ueda Hiroyuki , Hozawa Atsushi 
Published: August 2020

AbstractRecently, the sodium (Na)/potassium (K) ratio was reported to be associated with blood pressure (BP). A Na/K ratio self-monitoring device using spot urine was established recently. Here, we assessed whether the urinary Na/K ratio change measured using the Na/K device was associated with BP change in a health checkup setting. We targeted 12,890 participants who attended the health checkup in Tome City, Miyagi between 2017 and 2018. Tome City introduced urinary Na/K ratio measurements during health checkups since 2017. For each year, we compared the baseline characteristics according to the urinary Na/K ratio and BP level. We assessed the relationship between change in urinary Na/K ratio and BP change using multiple regression analyses adjusted for age, sex, and change in body mass index (BMI) and alcohol intake. The average urinary Na/K ratio was significantly lower in 2018 than in 2017 (5.4 ± 3.0 to 4.9 ± 2.2, P < 0.01). The systolic BP of the participants in 2018 (130.9 ± 17.4 mmHg) was lower than that in 2017 (132.1 ± 17.9 mmHg). Moreover, the change in systolic BP and diastolic BP was positively associated with the change in urinary Na/K ratio. In conclusion, the association of the change in urinary Na/K ratio with hypertension and changes in systolic and diastolic BP can be explained by a change in alcohol intake, BMI, and urinary Na/K ratio. Therefore, measuring the urinary Na/K ratio in community settings is a potential population approach for counteracting hypertension.
Resonant thermal energy transfer to magnons in a ferromagnetic nanolayer
Authors: Kobecki Michal , Scherbakov Alexey V. , Linnik Tetiana L. , Kukhtaruk Serhii M. , Gusev Vitalyi E. , Pattnaik Debi P. , Akimov Ilya A. , Rushforth Andrew W. , Akimov Andrey V. , Bayer Manfred 
Published: August 2020

AbstractEnergy harvesting is a concept which makes dissipated heat useful by transferring thermal energy to other excitations. Most of the existing principles are realized in systems which are heated continuously. We present the concept of high-frequency energy harvesting where the dissipated heat in a sample excites resonant magnons in a thin ferromagnetic metal layer. The sample is excited by femtosecond laser pulses with a repetition rate of 10 GHz, which results in temperature modulation at the same frequency with amplitude ~0.1 K. The alternating temperature excites magnons in the ferromagnetic nanolayer which are detected by measuring the net magnetization precession. When the magnon frequency is brought onto resonance with the optical excitation, a 12-fold increase of the amplitude of precession indicates efficient resonant heat transfer from the lattice to coherent magnons. The demonstrated principle may be used for energy harvesting in various nanodevices operating at GHz and sub-THz frequency ranges.
Strength of immune selection in tumors varies with sex and age
Authors: Castro Andrea , Pyke Rachel Marty , Zhang Xinlian , Thompson Wesley Kurt , Day Chi-Ping , Alexandrov Ludmil B. , Zanetti Maurizio , Carter Hannah 
Published: August 2020

AbstractIndividual MHC genotype constrains the mutational landscape during tumorigenesis. Immune checkpoint inhibition reactivates immunity against tumors that escaped immune surveillance in approximately 30% of cases. Recent studies demonstrated poorer response rates in female and younger patients. Although immune responses differ with sex and age, the role of MHC-based immune selection in this context is unknown. We find that tumors in younger and female individuals accumulate more poorly presented driver mutations than those in older and male patients, despite no differences in MHC genotype. Younger patients show the strongest effects of MHC-based driver mutation selection, with younger females showing compounded effects and nearly twice as much MHC-II based selection. This study presents evidence that strength of immune selection during tumor development varies with sex and age, and may influence the availability of mutant peptides capable of driving effective response to immune checkpoint inhibitor therapy.
Radiocarbon offsets and old world chronology as relevant to Mesopotamia, Egypt, Anatolia and Thera (Santorini)
Authors: Manning Sturt W. , Wacker Lukas , Büntgen Ulf , Bronk Ramsey Christopher , Dee Michael W. , Kromer Bernd , Lorentzen Brita , Tegel Willy 
Published: August 2020

AbstractThe new IntCal20 radiocarbon record continues decades of successful practice by employing one calibration curve as an approximation for different regions across the hemisphere. Here we investigate three radiocarbon time-series of archaeological and historical importance from the Mediterranean-Anatolian region, which indicate, or may include, offsets from IntCal20 (~0–22 14C years). While modest, these differences are critical for our precise understanding of historical and environmental events across the Mediterranean Basin and Near East. Offsets towards older radiocarbon ages in Mediterranean-Anatolian wood can be explained by a divergence between high-resolution radiocarbon dates from the recent generation of accelerator mass spectrometry (AMS) versus dates from previous technologies, such as low-level gas proportional counting (LLGPC) and liquid scintillation spectrometry (LSS). However, another reason is likely differing growing season lengths and timings, which would affect the seasonal cycle of atmospheric radiocarbon concentrations recorded in different geographic zones. Understanding and correcting these offsets is key to the well-defined calendar placement of a Middle Bronze Age tree-ring chronology. This in turn resolves long-standing debate over Mesopotamian chronology in the earlier second millennium BCE. Last but not least, accurate dating is needed for any further assessment of the societal and environmental impact of the Thera/Santorini volcanic eruption.
A dual mechanism underlying retroactive shifts of auditory spatial attention: dissociating target- and distractor-related modulations of alpha lateralization
Authors: Klatt Laura-Isabelle , Getzmann Stephan , Begau Alexandra , Schneider Daniel 
Published: August 2020

AbstractAttention can be allocated to mental representations to select information from working memory. To date, it remains ambiguous whether such retroactive shifts of attention involve the inhibition of irrelevant information or the prioritization of relevant information. Investigating asymmetries in posterior alpha-band oscillations during an auditory retroactive cueing task, we aimed at differentiating those mechanisms. Participants were cued to attend two out of three sounds in an upcoming sound array. Importantly, the resulting working memory representation contained one laterally and one centrally presented item. A centrally presented retro-cue then indicated the lateral, the central, or both items as further relevant for the task (comparing the cued item(s) to a memory probe). Time–frequency analysis revealed opposing patterns of alpha lateralization depending on target eccentricity: A contralateral decrease in alpha power in target lateral trials indicated the involvement of target prioritization. A contralateral increase in alpha power when the central item remained relevant (distractor lateral trials) suggested the de-prioritization of irrelevant information. No lateralization was observed when both items remained relevant, supporting the notion that auditory alpha lateralization is restricted to situations in which spatial information is task-relevant. Altogether, the data demonstrate that retroactive attentional deployment involves excitatory and inhibitory control mechanisms.
Lithium chloride enhances serotonin induced calcium activity in EGFP-GnIH neurons
Authors: Teo Chuin Hau , Soga Tomoko , Parhar Ishwar 
Published: August 2020

AbstractNeurons synthesizing gonadotropin-inhibitory hormone (GnIH) have been implicated in the control of reproduction, food intake and stress. Serotonin (5-HT) receptors have been shown in GnIH neurons; however, their functional role in the regulation of GnIH neurons remains to be elucidated. In this study, we measured intracellular calcium ion levels following 5-HT treatment to hypothalamic primary cultures of enhanced fluorescent green protein-tagged GnIH (EGFP-GnIH) neurons from Wistar rat pups of mixed sex. Three days after initial seeding of the primary cultures, the test groups were pre-treated with lithium chloride to selectively inhibit glycogen synthase kinase 3 beta to promote intracellular calcium levels, whereas the control groups received culture medium with no lithium chloride treatment. 24 h later, the cultures were incubated with rhodamine-2AM (rhod-2AM) calcium indicator dye for one hour prior to imaging. 5-HT was added to the culture dishes 5 min after commencement of imaging. Analysis of intracellular calcium levels in EGFP-GnIH neurons showed that pre-treatment with lithium chloride before 5-HT treatment resulted in significant increase in intracellular calcium levels, two times higher than the baseline. This suggests that lithium chloride enhances the responsiveness of GnIH neurons to 5-HT.
Characterization of deep-sea benthic invertebrate megafauna of the Galapagos Islands
Authors: Salinas-de-León Pelayo , Martí-Puig Patricia , Buglass Salome , Arnés-Urgellés Camila , Rastoin-Laplane Etienne , Creemers Marie , Cairns Stephen , Fisher Charles , O’Hara Timothy , Ott Bruce , Raineault Nicole A. , Reiswig Henry , Rouse Greg , Rowley Sonia , Shank Timothy M. , Suarez Jenifer , Watling Les , Wicksten Mary K. , Marsh Leigh 
Published: August 2020

AbstractThe deep sea represents the largest and least explored biome on the planet. Despite the iconic status of the Galapagos Islands and being considered one of the most pristine locations on earth, the deep-sea benthic ecosystems of the archipelago are virtually unexplored in comparison to their shallow-water counterparts. In 2015, we embarked on a multi-disciplinary scientific expedition to conduct the first systematic characterization of deep-sea benthic invertebrate communities of the Galapagos, across a range of habitats. We explored seven sites to depths of over 3,300 m using a two-part Remotely Operated Vehicle (ROV) system aboard the E/V Nautilus, and collected 90 biological specimens that were preserved and sent to experts around the world for analysis. Of those, 30 taxa were determined to be undescribed and new to science, including members of five new genera (2 sponges and 3 cnidarians). We also systematically analysed image frame grabs from over 85 h of ROV footage to investigate patterns of species diversity and document the presence of a range of underwater communities between depths of 290 and 3,373 m, including cold-water coral communities, extensive glass sponge and octocoral gardens, and soft-sediment faunal communities. This characterization of Galapagos deep-sea benthic invertebrate megafauna across a range of ecosystems represents a first step to study future changes that may result from anthropogenic impacts to the planet’s climate and oceans, and informed the creation of fully protected deep-water areas in the Galapagos Marine Reserve that may help preserve these unique communities in our changing planet.