bluuebunny/crossref_metadata_2025_split huggingface dataset:
SEWMS: An edge‐based smart wearable maintenance system in communication network
Authors: Rui Lanlan , Qin Yabin , Li Biyao , Wang Ying , Huang Haoqiu 
Published: December 2019

SummaryThe development of the Internet of Things (IoT) and wearable technology provides an opportunity for the development of maintenance of communication. The use of wearable technology and instant messaging technology of IoT can improve the support capabilities and data interaction ability of on‐site maintenance of the communication network. Existing communication maintenance systems lack real‐time operation and maintenance of data interaction. In the field operation decision‐making and execution process, there are problems of lack of field links and inconvenient information interaction. On‐site maintenance mainly relies on maintenance personnel to actively search for information, and the retrieval results are lacking of personalization, which makes it difficult to meet the needs of on‐site maintenance of the communication network. Edge computing and information push technology can solve these problems to some extent. In this paper, we focus on the current low level in information, complicated scenes, and various information of on‐site maintenance and propose a dynamic context‐aware information push algorithm. The simulation results demonstrate that the algorithm delivers good performance in terms of precision, recall, and F1. Besides, we present a smart wearable maintenance system, an edge computing–assisted IoT platform for the real‐time guidance of technical experts and systems for on‐site maintenance personnel, aiming to improve the efficiency and quality of on‐site maintenance.
Salivary neoplasia in dogs and cats: 1996–2017
Authors: Cray Megan , Selmic Laura E. , Ruple Audrey 
Published: December 2019

AbstractObjectiveThe objectives of this study were to report the contemporary demographical information, provide the incidence of and to assess sex and breed predisposition of salivary gland neoplasia in dogs and cats.Materials and MethodsInformation was collected from cats or dogs with salivary neoplasia (cases) and controls from the 26 university veterinary teaching hospitals within the Veterinary Medical Data Base. A total of 56 dogs and 24 cats were identified as having been diagnosed with salivary neoplasia.ResultsThe incidence of salivary neoplasia in this population was calculated to be 15.3 per 100,000 dogs and 26.3 per 100,000 cats. The specific anatomic location of the salivary neoplasia was unable to be determined in 90.8% of cases in both dogs and cats. Results of the univariable conditional logistic regression models revealed no increased risk of salivary neoplasia in dogs or cats of any sex or neuter status (dogs:p = .26; cats:p = .45). There was no breed disposition within the feline species for salivary neoplasia. However, in the conditional logistic regression for dogs, poodles (toy and standard) trended towards significance (p = .075) with an odds ratio of 6.83 (95% CI: 1.16–40.10) compared to mixed breeds.Conclusions and clinical relevanceThe present study's results differ from previous conclusions made in regards to predisposed breeds and tumour location. Additional epidemiological studies should be performed to help in determining risk factors for salivary gland neoplasia.
Dmc1 is a candidate for temperature tolerance during wheat meiosis
Authors: Draeger Tracie , C. Martin Azahara , Alabdullah Abdul Kader , Pendle Ali , Rey María-Dolores , Shaw Peter , Moore Graham 
Published: December 2019

AbstractKey messageThe meiotic recombination geneDmc1on wheat chromosome 5D has been identified as a candidate for the maintenance of normal chromosome synapsis and crossover at low and possibly high temperatures.AbstractWe initially assessed the effects of low temperature on meiotic chromosome synapsis and crossover formation in the hexaploid wheat (Triticum aestivumL.) variety ‘Chinese Spring’. At low temperatures, asynapsis and chromosome univalence have been observed before in Chinese Spring lines lacking the long arm of chromosome 5D (5DL), which led to the proposal that 5DL carries a gene (Ltp1) that stabilises wheat chromosome pairing at low temperatures. In the current study, Chinese Spring wild type and 5DL interstitial deletion mutant plants were exposed to low temperature in a controlled environment room during a period from premeiotic interphase to early meiosis I. A 5DL deletion mutant was identified whose meiotic chromosomes exhibit extremely high levels of asynapsis and chromosome univalence at metaphase I after 7 days at 13 °C, suggesting thatLtp1is deleted in this mutant. Immunolocalisation of the meiotic proteins ASY1 and ZYP1 onltp1mutants showed that low temperature results in a failure to complete synapsis at pachytene. KASP genotyping revealed that theltp1mutant has a 4-Mb deletion in 5DL. Of 41 genes within this deletion region, the strongest candidate for the stabilisation of chromosome pairing at low temperatures is the meiotic recombination geneDmc1.Theltp1mutants were subsequently treated at 30 °C for 24 h during meiosis and exhibited a reduced number of crossovers and increased univalence, though to a lesser extent than at 13 °C. We therefore renamed ourltp1mutant ‘ttmei1’ (temperature-tolerantmeiosis1) to reflect this additional loss of high temperature tolerance.
Safety, tolerability, pharmacokinetics, and pharmacodynamics of low dose lysergic acid diethylamide (LSD) in healthy older volunteers
Authors: Family Neiloufar , Maillet Emeline L. , Williams Luke T. J. , Krediet Erwin , Carhart-Harris Robin L. , Williams Tim M. , Nichols Charles D. , Goble Daniel J. , Raz Shlomi 
Published: December 2019

Abstract
Abstract
Research has shown that psychedelics, such as lysergic acid diethylamide (LSD), have profound anti-inflammatory properties mediated by 5-HT2A receptor signaling, supporting their evaluation as a therapeutic for neuroinflammation associated with neurodegenerative disease.

Objective
This study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of orally repeated administration of 5 μg, 10 μg, and 20 μg LSD in older healthy individuals. In the current paper, we present safety, tolerability, pharmacokinetics, and pharmacodynamic measures that relate to safety, tolerability, and dose response.

Methods
This was a phase 1 double-blind, placebo-controlled, randomized study. Volunteers were randomly assigned to 1 of 4 dose groups (5 μg, 10 μg, 20 μg LSD, and placebo), and received their assigned dose on six occasions (i.e., every 4 days).

Results
Forty-eight older healthy volunteers (mean age = 62.9 years) received placebo (n = 12), 5 μg (n = 12), 10 μg (n = 12), or 20 μg (n = 12) LSD. LSD plasma levels were undetectable for the 5 μg group and peak blood plasma levels for the 10 μg and 20 μg groups occurred at 30 min. LSD was well tolerated, and the frequency of adverse events was no higher than for placebo. Assessments of cognition, balance, and proprioception revealed no impairment.

Conclusions
Our results suggest safety and tolerability of orally administered 5 μg, 10 μg, and 20 μg LSD every fourth day over a 21-day period and support further clinical development of LSD for the treatment and prevention of Alzheimer’s disease (AD).
Inotersen preserves or improves quality of life in hereditary transthyretin amyloidosis
Authors: Coelho Teresa , Yarlas Aaron , Waddington-Cruz Marcia , White Michelle K. , Sikora Kessler Asia , Lovley Andrew , Pollock Michael , Guthrie Spencer , Ackermann Elizabeth J. , Hughes Steven G. , Karam Chafic , Khella Sami , Gertz Morie , Merlini Giampaolo , Obici Laura , Schmidt Hartmut H. , Polydefkis Michael , Dyck P. James B. , Brannagan III Thomas H. , Conceição Isabel , Benson Merrill D. , Berk John L. 
Published: December 2019

Abstract
Objective
To examine the impact on quality of life (QOL) of patients with hATTR amyloidosis with polyneuropathy treated with inotersen (Tegsedi™) versus placebo.

Methods
Data were from the NEURO-TTR trial (ClinicalTrials.gov Identifier: NCT01737398), a phase 3, multinational, randomized, double-blind, placebo-controlled study of inotersen in patients with hATTR amyloidosis with polyneuropathy. At baseline and week 66, QOL measures—the Norfolk-QOL-Diabetic Neuropathy (DN) questionnaire and SF-36v2® Health Survey (SF-36v2)—were assessed. Treatment differences in mean changes in QOL from baseline to week 66 were tested using mixed-effect models with repeated measures. Responder analyses compared the percentages of patients whose QOL meaningfully improved or worsened from baseline to week 66 in inotersen and placebo arms. Descriptive analysis of item responses examined treatment differences in specific activities and functions at week 66.

Results
Statistically significant mean differences between treatment arms were observed for three of five Norfolk-QOL-DN domains and five of eight SF-36v2 domains, with better outcomes for inotersen than placebo in physical functioning, activities of daily living, neuropathic symptoms, pain, role limitations due to health problems, and social functioning. A larger percentage of patients in the inotersen arm than the placebo arm showed preservation or improvement in Norfolk-QOL-DN and SF-36v2 scores from baseline to week 66. Responses at week 66 showed more substantial problems with daily activities and functioning for patients in the placebo arm than in the inotersen arm.

Conclusion
Patients with hATTR amyloidosis with polyneuropathy treated with inotersen showed preserved or improved QOL at 66 weeks compared to those who received placebo.
Design and tailoring of an artificial DNA scaffolding system for efficient lycopene synthesis using zinc-finger-guided assembly
Authors: Xu Xian , Tian Liqing , Tang Susu , Xie Chengjia , Xu Jiali , Jiang Ling 
Published: December 2019

Abstract
A highly efficient lycopene production system was constructed by assembling enzymes fused to zinc-finger motifs on DNA scaffolds in vitro and in vivo. Three key enzymes of the lycopene synthesis pathway, geranylgeranyl diphosphate synthase, phytoene synthase, and phytoene desaturase, were fused with zinc-finger proteins, expressed and purified. Recombinant plasmids of the pS series containing DNA scaffolds that the zinc-finger proteins can specifically bind to were constructed. In the in vitro system, the production efficiency of lycopene was improved greatly after the addition of the scaffold plasmid pS231. Subsequently, the plasmid pET-AEBI was constructed and introduced into recombinant Escherichia coli BL21 (DE3) for expression, together with plasmids of the pS series. The lycopene production rate and content of the recombinant strain pp231 were higher than that of all strains carrying the DNA scaffold and the control. With the addition of cofactors and substrates in the lycopene biosynthesis pathway, the lycopene yield of pp231 reached 632.49 mg/L at 40 h, representing a 4.7-fold increase compared to the original recombinant strain pA1A3. This DNA scaffold system can be used as a platform for the construction and production of many biochemicals synthesized via multi-enzyme cascade reactions.
Genomics-driven discovery of the biosynthetic gene cluster of maduramicin and its overproduction in Actinomadura sp. J1-007
Authors: Liu Ran , Fang Fang , An Ziheng , Huang Renqiong , Wang Yong , Sun Xiao , Fu Shuai , Fu Aisi , Deng Zixin , Liu Tiangang 
Published: December 2019

Abstract
Maduramicin is the most efficient and possesses the largest market share of all anti-coccidiosis polyether antibiotics (ionophore); however, its biosynthetic gene cluster (BGC) has yet to been identified, and the associated strains have not been genetically engineered. Herein, we performed whole-genome sequencing of a maduramicin-producing industrial strain of Actinomadura sp. J1-007 and identified its BGC. Additionally, we analyzed the identified BGCs in silico to predict the biosynthetic pathway of maduramicin. We then developed a conjugation method for the non-spore-forming Actinomadura sp. J1-007, consisting of a site-specific integration method for gene overexpression. The maduramicin titer increased by 30% to 7.16 g/L in shake-flask fermentation following overexpression of type II thioesterase MadTE that is the highest titer at present. Our findings provide insights into the biosynthetic mechanism of polyethers and provide a platform for the metabolic engineering of maduramicin-producing microorganisms for overproduction and development of maduramicin analogs in the future.
The Gray Monoidal Product of Double Categories
Authors: Böhm Gabriella 
Published: December 2019

AbstractThe category of double categories and double functors is equipped with a symmetric closed monoidal structure. For any double category $${\mathbb {A}}$$A, the corresponding internal hom functor "Equation missing" sends a double category $${\mathbb {B}}$$B to the double category whose 0-cells are the double functors $${\mathbb {A}} \rightarrow {\mathbb {B}}$$A→B, whose horizontal and vertical 1-cells are the horizontal and vertical pseudo transformations, respectively, and whose 2-cells are the modifications. Some well-known functors of practical significance are checked to be compatible with this monoidal structure.
Positive Psychology of Malaysian University Students: Impacts of Engagement, Motivation, Self-Compassion, and Well-being on Mental Health
Authors: Kotera Yasuhiro , Ting Su-Hie 
Published: December 2019

AbstractMalaysia plays a key role in education of the Asia Pacific, expanding its scholarly output rapidly. However, mental health of Malaysian students is challenging, and their help-seeking is low because of stigma. This study explored the relationships between mental health and positive psychological constructs (academic engagement, motivation, self-compassion, and well-being), and evaluated the relative contribution of each positive psychological construct to mental health in Malaysian students. An opportunity sample of 153 students completed the measures regarding these constructs. Correlation, regression, and mediation analyses were conducted. Engagement, amotivation, self-compassion, and well-being were associated with, and predicted large variance in mental health. Self-compassion was the strongest independent predictor of mental health among all the positive psychological constructs. Findings can imply the strong links between mental health and positive psychology, especially self-compassion. Moreover, intervention studies to examine the effects of self-compassion training on mental health of Malaysian students appear to be warranted.
Focused Audification and the optimization of its parameters
Authors: Groß-Vogt Katharina , Frank Matthias , Höldrich Robert 
Published: December 2019

AbstractWe present a sonification method which we call Focused Audification (FA; previously: Augmented Audification) that allows to expand pure audification in a flexible way. It is based on a combination of single-side-band modulation and a pitch modulation of the original data stream. Based on two free parameters, the sonification’s frequency range is adjustable to the human hearing range and allows to interactively zoom into the data set at any scale. The parameters have been adjusted in a multimodal experiment on cardiac data by laypeople. Following from these results we suggest a procedure for parameter optimization to achieve an optimal listening range for any data set, adjusted to human speech.
Biomarker Application for Precision Medicine in Stroke
Authors: Simpkins Alexis N. , Janowski Miroslaw , Oz Helieh S. , Roberts Jill , Bix Gregory , Doré Sylvain , Stowe Ann M. 
Published: December 2019

AbstractStroke remains one of the leading causes of long-term disability and mortality despite recent advances in acute thrombolytic therapies. In fact, the global lifetime risk of stroke in adults over the age of 25 is approximately 25%, with 24.9 million cases of ischemic stroke and 18.7 million cases of hemorrhagic stroke reported in 2015. One of the main challenges in developing effective new acute therapeutics and enhanced long-term interventions for stroke recovery is the heterogeneity of stroke, including etiology, comorbidities, and lifestyle factors that uniquely affect each individual stroke survivor. In this comprehensive review, we propose that future biomarker studies can be designed to support precision medicine therapeutic interventions after stroke. The current challenges in defining ideal biomarkers for stroke are highlighted, including consideration of disease course, age, lifestyle factors, and subtypes of stroke. This overview of current clinical trials includes biomarker collection, and concludes with an example of biomarker design for aneurysmal subarachnoid hemorrhage. With the advent of “-omics” studies, neuroimaging, big data, and precision medicine, well-designed stroke biomarker trials will greatly advance the treatment of a disease that affects millions globally every year.
Screening for personality disorders in geriatric medicine outpatients
Authors: Meuwissen-van Pol E. C. H. , Rossi G. , de Weerd-Spaetgens C. M. E. E. , van Alphen S. P. J. 
Published: December 2019

Abstract
Purpose
Personality disorder (PD) assessment in older adults is challenging. In geriatric medicine, older adults with multi-morbidity are treated for their somatic, psychogeriatric, functional and social complaints and the presence of a PD can be a complicating factor in this treatment. Therefore, this study evaluates the diagnostic accuracy of a PD screening instrument, the Gerontological Personality disorder Scale (GPS) in a Dutch geriatric medicine population.

Methods
Using an informant-based personality questionnaire (HAP) as a reference criterion, the psychometric properties of the GPS-informant version were assessed in a sample of N = 160 (62 male) outpatients (mean age = 81.7).

Results
The internal consistency of the GPS (total score), Cronbach’s alpha, was α = 0.69. And the average inter-item correlation (total score) was 0.14. The test–retest reliability was rs = 0.68. The sensitivity and specificity for the GPS were 0.91 and 0.67, respectively. The GPS items showed predictive validity for PD status with 87.4% of predictions being accurate based on a logistic regression analysis.

Conclusions
This is the first psychometric study to use the GPS as an age-specific screening instrument for PDs in Dutch geriatric medicine outpatients. The GPS is an adequate screening tool for PDs in geriatric medicine, given the high sensitivity. The diagnostic accuracy of the GPS-informant version is fair to excellent.
Differences in self‐reported character strengths across adolescence
Authors: Brown Mitch , Blanchard Tamar , McGrath Robert E. 
Published: December 2019

ABSTRACTIntroductionAlthough typically considered a stable trait, character strengths may be subject to temporal changes. Whereas research has investigated these changes across adulthood, the pivotal period of adolescence remains relatively understudied.MethodTo identify potential developmental differences in character strengths, we conducted a cross‐sectional exploratory analysis of 24 Character strengths, assessed by the VIA‐Youth, across youth between ages 10 and 17 from four highly represented countries (N = 12,871).ResultsThe general pattern was for older adolescents to generate lower scores in many traits compared to younger adolescents. When considering gender as a potential moderator, girls, on average, scored higher on most strengths, but also showed more consistently lower scores across ages.ConclusionFindings provide a nuanced understanding of developmental differences in character across adolescence in a large‐scale study. We frame these findings in the context of recent work investigating how character strengths develop throughout adolescence and offer suggestions for future research and interventions.
Interpretations of sustainability beyond the middle class
Authors: Beasy Kim 
Published: December 2019

AbstractCritical discourses of sustainability challenge modern rhetoric of economic growth and challenge current modes of social development. Yet sustainability discourses are shaped predominantly by the perspectives and interests of middle-class, tertiary-educated urban policy makers or environmentalists, and have insufficiently engaged people beyond these cohorts, even in the advanced capitalist societies where they have originated. This article shares findings from a study that investigated how people who are not strongly engaged with sustainability discourses understand and engage with many of the underlying concerns that animate these discourses from the context of their situated, everyday experiences. This is important information for sustainability educators, because it challenges dominant ideas of what sustainabilityisand offers new and alternate ways of engaging different groups of people in actions for sustainability. Bourdieu’s concepts of habitus, field and capital were used to inform the research design that employed focus groups and interviews with people from a range of socio-economic and cultural backgrounds and life stages in Tasmania, Australia. The findings provide insight into the ways in which people who are disengaged from discourses of sustainability may be actively engaged in practices of sustainability that may provide practical guidance for environmentalists and policy makers concerning how current discourses of sustainability reflect specific social contexts and experiences.
Wet subglacial bedforms of the NE Greenland Ice Stream shear margins
Authors: Riverman Kiya L. , Anandakrishnan Sridhar , Alley Richard B. , Holschuh Nicholas , Dow Christine F. , Muto Atsuhiro , Parizek Byron R. , Christianson Knut , Peters Leo E. 
Published: December 2019

AbstractWe describe elongate, wet, subglacial bedforms in the shear margins of the NE Greenland Ice Stream and place some constraints on their formation. Lateral shear margin moraines have been observed across the previously glaciated landscape, but little is known about the ice-flow conditions necessary to form these bedforms. Here we describe in situ sediment bedforms under the NE Greenland Ice Stream shear margins that are observed in active-source seismic and ground-penetrating radar surveys. We find bedforms in the shear margins that are ~500 m wide, ~50 m tall, and elongated nearly parallel to ice-flow, including what we believe to be the first subglacial observation of a shear margin moraine. Acoustic impedance analysis of the bedforms shows that they are composed of unconsolidated, deformable, water-saturated till. We use these geophysical observations to place constraints on the possible formation mechanism of these subglacial features.