bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cell‐of‐origin determined by both gene expression profiling and immunohistochemistry is the strongest predictor of survival in patients with diffuse large B‐cell lymphoma
Authors: Abdulla Maysaa , Hollander Peter , Pandzic Tatjana , Mansouri Larry , Ednersson Susanne Bram , Andersson Per‐Ola , Hultdin Magnus , Fors Maja , Erlanson Martin , Degerman Sofie , Petersen Helga Munch , Asmar Fazila , Grønbæk Kirsten , Enblad Gunilla , Cavelier Lucia , Rosenquist Richard , Amini Rose‐Marie 
Published: October 2019

AbstractThe tumor cells in diffuse large B‐cell lymphomas (DLBCL) are considered to originate from germinal center derived B‐cells (GCB) or activated B‐cells (ABC). Gene expression profiling (GEP) is preferably used to determine the cell of origin (COO). However, GEP is not widely applied in clinical practice and consequently, several algorithms based on immunohistochemistry (IHC) have been developed. Our aim was to evaluate the concordance of COO assignment between the Lymph2Cx GEP assay and the IHC‐based Hans algorithm, to decide which model is the best survival predictor. Both GEP and IHC were performed in 359 homogenously treated Swedish and Danish DLBCL patients, in a retrospective multicenter cohort. The overall concordance between GEP and IHC algorithm was 72%; GEP classified 85% of cases assigned as GCB by IHC, as GCB, while 58% classified as non‐GCB by IHC, were categorized as ABC by GEP. There were significant survival differences (overall survival and progression‐free survival) if cases were classified by GEP, whereas if cases were categorized by IHC only progression‐free survival differed significantly. Importantly, patients assigned as non‐GCB/ABC both by IHC and GEP had the worst prognosis, which was also significant in multivariate analyses. Double expression of MYC and BCL2 was more common in ABC cases and was associated with a dismal outcome. In conclusion, to determine COO both by IHC and GEP is the strongest outcome predictor to identify DLBCL patients with the worst outcome.
Duplication 2p16 is associated with perisylvian polymicrogyria
Authors: Amrom Dina , Poduri Annapurna , Goldman Jennifer S. , Dan Bernard , Deconinck Nicolas , Pichon Bruno , Nadaf Javad , Andermann Frederick , Andermann Eva , Walsh Christopher A. , Dobyns William B. 
Published: October 2019

AbstractPolymicrogyria (PMG) is a heterogeneous brain malformation that may result from prenatal vascular disruption or infection, or from numerous genetic causes that still remain difficult to identify. We identified three unrelated patients with polymicrogyria and duplications of chromosome 2p, defined the smallest region of overlap, and performed gene pathway analysis using Cytoscape. The smallest region of overlap in all three children involved 2p16.1‐p16.3. All three children have bilateral perisylvian polymicrogyria (BPP), intrauterine and postnatal growth deficiency, similar dysmorphic features, and poor feeding. Two of the three children had documented intellectual disability. Gene pathway analysis suggested a number of developmentally relevant genes and gene clusters that were over‐represented in the critical region. We narrowed a rare locus for polymicrogyria to a region of 2p16.1‐p16.3 that contains 33–34 genes, 23 of which are expressed in cerebral cortex during human fetal development. Using pathway analysis, we showed that several of the duplicated genes contribute to neurodevelopmental pathways including morphogen, cytokine, hormonal and growth factor signaling, regulation of cell cycle progression, cell morphogenesis, axonal guidance, and neuronal migration. These findings strengthen the evidence for a novel locus associated with polymicrogyria on 2p16.1‐p16.3, and comprise the first step in defining the underlying genetic etiology.
A Realistic Evaluation of Danish Perioperative Nurses’ Documentation Practices
Authors: Søndergaard Susanne Friis , Frederiksen Kirsten , Sørensen Erik Elgaard , Lorentzen Vibeke 
Published: October 2019

ABSTRACTNursing care documentation is an important aspect of clinical decision‐making processes and affects patient safety. Documentation in the perioperative setting has been described as poor and incomplete and varies among nurses. The purpose of this qualitative study was to examine perioperative nurses’ documentation practices using a realistic evaluation framework that focuses on relationships between context, mechanisms, and outcomes. Through participant observations using multiple qualitative data‐generation methods, the study found that perioperative nurses’ documentation practices are driven by a mix of educational, cultural, and organizational factors, including competing demands, local values and traditions, and everyday circumstances. Understanding the cultures of different subgroups in the perioperative setting may help improve nurses’ documentation practices.
Removal of acid dyes from aqueous solutions using a new eco‐friendly nanocomposite of CoFe2O4 modified with Tragacanth gum
Authors: Moghaddam Ali Zeraatkar , Jazi Mehdi Erfani , Allahrasani Ali , Ganjali Mohammad Reza , Badiei Alireza 
Published: October 2019

ABSTRACTA new composite of cobalt ferrite and Tragacanth gum (TG) was developed and applied to remove methyl orange (MO) and methyl red (MR) from wastewater samples simultaneously. The results showed that the presence of TG improved the capability of cobalt ferrite in removing the pollutants in considerably. The adsorption properties and surface morphology of the sorbent were compared with those of bare cobalt ferrite, TG, and TG grafted copolymer. The properties of the adsorbents were studied using Fourier transform infrared, scanning electron microscope, transmission electron microscope, X‐ray diffraction, and vibrating sample magnetometer, and the effects of different factors such as the amount of the adsorbent, sample pH, contact time, and initial concentration were also evaluated and optimized through response surface methodology using central composite design. The optimal conditions for the adsorption of both dyes (100 mg L−1 as the concentration) were pH of 4.0, adsorbent dose of 0.5 mg mL−1, and contact time of 110 min. Under these conditions, the MO and MR adsorption processes were found to follow pseudo‐second‐order kinetic model. The equilibrium adsorption data followed the Langmuir isotherm and the highest adsorption capacity was determined to be 336 and 387 mg g−1 for MO and MR, respectively. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48605.
Enhanced mechanical properties of poly(lactic acid) composites with ultrathin nanosheets of MXene modified by stearic acid
Authors: Yi Zhuwu , Yang Jian , Liu Xiaochao , Mao Long , Cui Lingna , Liu Yuejun 
Published: October 2019

ABSTRACTMXene modified by stearic acid (Ti3C2Tx‐g‐SA) is incorporated into poly(lactic acid) (PLA) matrix to prepare Ti3C2Tx‐g‐SA/PLA composites. The effects of Ti3C2Tx‐g‐SA to pure PLA are investigated, including crystallization, mechanical, and thermal properties. Fourier transform infrared spectroscopy and X‐ray diffraction analyses confirm that Ti3C2Tx interlayer is successfully intercalated by SA, and the interlayer spacing of Ti3C2Tx is increased. Differential scanning calorimetry illustrates that the cold crystallization enthalpy (ΔHcc), melting enthalpy (ΔHm), and crystallinity (Xc) of Ti3C2Tx‐g‐SA/PLA composites are improved by the plasticization and heterogeneous nucleation effect of Ti3C2Tx‐g‐SA. Specially, the Ti3C2Tx‐g‐SA/PLA composites exhibit excellent mechanical properties at an appropriate content of the Ti3C2Tx‐g‐SA. Compared with pure PLA, the elongation at break of the Ti3C2Tx‐g‐SA/PLA composite is increased 5.9‐fold (up to 131.6%) when only containing 0.5 wt % Ti3C2Tx‐g‐SA. Besides, the Ti3C2Tx‐g‐SA/PLA composites exhibit good thermal stability in the low loading (lower than 1 wt %) of Ti3C2Tx‐g‐SA. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48621.
A review of data science in business and industry and a future view
Authors: Vicario Grazia , Coleman Shirley 
Published: October 2019

AbstractThe aim of this paper is to frame Data Science, a fashion and emerging topic nowadays in the context of business and industry. We open with a discussion about the origin of Data Science and its requirement for a challenging mix of capability in data analytics, information technology, and business know‐how. The mission of Data Science is to provide new or revised computational theory able to extract useful information from the massive volumes of data collected at an accelerating pace. In fact, besides the traditional measurements, digital data obtained from images, text, audio, sensors, etc complement the survey. Then, we review the different and most popular methodologies among the practitioners of Data Science research and applications. In addition, because the emerging field requires personnel with new competences, we attempt to describe the Data Scientist profile, one of the sexiest jobs of the 21st Century according to Davenport and Patil. Most people are aware of the need to embrace Data Science, but they feel intimidated that they do not understand it and they worry that their jobs will disappear. We want to encourage them: Data Science is more likely to add value to jobs and enrich the lives of working people by helping them make better, more informed business decisions. We conclude this paper by presenting examples of Data Science in action in business and industry, to demonstrate the collection of specialist skills that must come together for this new science to be effective.
Getting Off to a Shaky Start: Specificity in Planning and Feedforward Control During Sensorimotor Learning in Autism Spectrum Disorder
Authors: Foster Nathan C. , Bennett Simon J. , Causer Joe , Elliott Digby , Bird Geoffrey , Hayes Spencer J. 
Published: October 2019

Whilst autistic individuals develop new internal action models during sensorimotor learning, the acquired movements are executed less accurately and with greater variability. Such movement profiles are related to differences in sensorimotor integration and/or altered feedforward/feedback sensorimotor control. We investigated the processes underlying sensorimotor learning in autism by quantifying accuracy and variability, relative timing, and feedforward and feedback control. Although autistic individuals demonstrated significant sensorimotor learning across trials, which was facilitated by processing knowledge‐of‐results feedback, motor execution was less accurate than non‐autistic individuals. Kinematic analysis indicated that autistic individuals showed significantly greater spatial variability at peak acceleration, but comparable spatial variability at peak velocity. These kinematic markers suggest that autistic movement profiles are driven by specific differences in sensorimotor control processes (i.e., internal action models) associated with planning and regulating the forces required to execute the movement. The reduction of variability at peak velocity indicates intact early feedback‐based sensorimotor control in autism. Understanding how feedforward and feedback‐based control processes operate provides an opportunity to explore how these control processes influence the acquisition of socio‐motor actions in autism. Autism Res 2020, 13: 423–435. © 2019 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryAutistic adults successfully learned a new movement skill by physically practising it, and using feedback about how well they had done to become more accurate. When looking at the movements in detail, autistic adults were more variable than non‐autistic adults when planning (e.g., how much force to use), and performing, the movement. These differences impact how autistic individuals learn different types of movement skills, which might influence how other behaviours (e.g., imitation) are acquired that support social interaction.
Why Do Intravascular Schistosomes Coat Themselves in Glycolytic Enzymes?
Authors: Pirovich David , Da'dara Akram A. , Skelly Patrick J. 
Published: October 2019

AbstractSchistosomes are intravascular parasitic helminths (blood flukes) that infect more than 200 million people globally. Proteomic analysis of the tegument (skin) of these worms has revealed the surprising presence of glycolytic enzymes on the parasite's external surface. Immunolocalization data as well as enzyme activity displayed by live worms confirm that functional glycolytic enzymes are indeed expressed at the host–parasite interface. Since these enzymes are traditionally considered to function intracellularly to drive glycolysis, in an extracellular location they are hypothesized to engage in novel “moonlighting” functions such as immune modulation and blood clot dissolution that promote parasite survival. For instance, several glycolytic enzymes can interact with plasminogen and promote its activation to the thrombolytic plasmin; some can inhibit complement function; some induce B cell proliferation or macrophage apoptosis. Several pathogenic bacteria and protists also express glycolytic enzymes externally, suggesting that moonlighting functions of extracellular glycolytic enzymes can contribute broadly to pathogen virulence. Also see the video abstract here https://youtu.be/njtWZ2y3k_I
Extensions of the probabilistic ranking metrics of competing treatments in network meta‐analysis to reflect clinically important relative differences on many outcomes
Authors: Mavridis Dimitris , Porcher Raphaël , Nikolakopoulou Adriani , Salanti Georgia , Ravaud Philippe 
Published: October 2019

AbstractOne of the key features of network meta‐analysis is ranking of interventions according to outcomes of interest. Ranking metrics are prone to misinterpretation because of two limitations associated with the current ranking methods. First, differences in relative treatment effects might not be clinically important and this is not reflected in the ranking metrics. Second, there are no established methods to include several health outcomes in the ranking assessments. To address these two issues, we extended the P‐score method to allow for multiple outcomes and modified it to measure the mean extent of certainty that a treatment is better than the competing treatments by a certain amount, for example, the minimum clinical important difference. We suggest to present the tradeoff between beneficial and harmful outcomes allowing stakeholders to consider how much adverse effect they are willing to tolerate for specific gains in efficacy. We used a published network of 212 trials comparing 15 antipsychotics and placebo using a random effects network meta‐analysis model, focusing on three outcomes; reduction in symptoms of schizophrenia in a standardized scale, all‐cause discontinuation, and weight gain.
A systematic literature review of socially responsible investment and environmental social governance metrics
Authors: Widyawati Luluk 
Published: October 2019

AbstractSocially responsible investment (SRI) encompasses both ethical and financial paradigms. This systematic literature review explores three key research themes within the SRI literature, identifying a significant disconnect between themes and a fixation on the financial (as opposed to ethical) paradigm. One of the foundations of SRI is environmental, social, and governance (ESG) metrics. This review confirms the importance of ESG metrics in the SRI field, as they play two crucial roles, namely, as a proxy for sustainability performance and an enabler of the SRI market. However, there are two main issues related to ESG metrics that undermine their reliability: a lack of transparency and a lack of convergence.
Acid lactic lactobacilli as a biotechnological toll to improve food quality and human health
Authors: Sousa Márcio A. de , Rama Gabriela Rabaioli , Volken de Souza Claucia F. , Granada Camille E. 
Published: October 2019

AbstractThe genus Lactobacillus has been widely used in food industry as starter or adjunct culture due to its probiotic features. Its biotechnological features improve the spectrum of uses of lactobacilli, which can affect its applicability directly. In this sense, this literature review gathers information and discusses the biotechnological potential of technological/probiotic lactobacilli aiming to improve food quality and human health. The primary and secondary metabolism generates specific substances, such as organic acids, carbon dioxide, hydrogen peroxide, diacetyl, fatty acids, and bacteriocins, which are determinant due to their probiotic potential, antimicrobial activity, and the development of new food flavors. In order to become industrially and commercially attractive, it is necessary develop a large‐scale process with lower production costs.
Reliable Methods for Analyses of Volatile Compounds of Copaifera Oleoresins Combining Headspace and Gas Chromatography
Authors: Mangabeira da Silva Jonas Joaquim , Pena Ribeiro Victor , Lemos Marivane , Miller Crotti Antônio Eduardo , Rogez Hervé , Kenupp Bastos Jairo 
Published: October 2019

AbstractTwo analytical methods were developed in this study for direct and fast chemical investigation of authentic Copaifera oleoresins (COR) and commercial products. Polydimethylsiloxane microfiber coupled to gas chromatography‐mass spectrometry (HS‐SPME‐GC/MS) showed the best results for oleoresin qualitative analysis, setting the following extraction conditions: equilibrium time of 15 min, extraction time of 30 min, extraction temperature at 60 °C and constant stirring of 400 rpm. Sesquiterpenes α‐copaene, β‐elemene, β‐caryophyllene and trans‐α‐bergamotene were found in all investigated samples. Quantitative analysis by gas chromatography coupled with flame ionization detector (GC‐FID) measured the content of the four sesquiterpenes in all samples. Qualitative and quantitative results showed important differences between COR of distinct species and commercial products. Data regarding the volatile composition of C. oblongifolia and C. trapezifolia oleoresins were first presented in this study and two new analytical methods were reported for direct and fast qualitative and quantitative analysis of COR.
Antiureolytic Activity of Substituted 2,5‐Diaminobenzoquinones
Authors: Nain‐Perez Amalyn , Barbosa Luiz C. A. , Rodríguez‐Hernández Diego , Mota Yane C. C. , Silva Thamara F. , Ramalho Teodorico C. , Modolo Luzia V. 
Published: October 2019

AbstractA series of 2,5‐bis(alkyl/arylamino)‐1,4‐benzoquinones (1–12) were investigatedin vitrofor their potential to inhibit the activity of jack bean urease. Compounds1–6,8,9,11and12effectively inhibited the jack bean urease activity by 90.8 % when tested at 5 μm, whereas7and10had relatively little effect. The IC50for most compounds was in the nanomolar range (31.4 nmand 36.0 nmfor2and8, respectively). The mechanism of enzyme inhibition shown by2and8is typical of mixed‐type inhibitors, whose affinity for the active site is over 6‐ and 2‐fold higher (Ki=30.0 and 22.8 nm, for2and8, respectively) than that of an allosteric site. Molecular docking studies revealed that both2and8establish hydrogen bonds with the amino acids residues Asp494, Met588, His593 and Ala636 in the active site of jack bean urease. These results indicate that such aminoquinones are useful leads for the development of more efficient urease inhibitors of wider utility.
Ultrasound controlled paclitaxel releasing system—A novel method for improving the availability of coronary artery drug coated balloon
Authors: Song Caixia , Zhou Chao , Zhang Junwei , Feng Xiangyi , Cui Xiaoshan , Zhang Feng , Ma Jianying , Toft Egon Steen , Ge Junbo , Zhang Haijun 
Published: October 2019

AbstractObjectivesThe aim of this study is to improve local‐drug delivery efficiency and tissue absorption using the ultrasound (US)‐responsible drug coating based on a newly developed US‐controlled paclitaxel release balloon.BackgroundLow availability of the drug coating remains a major concern of the current drug coated balloon (DCB). The goal of this study is to develop a method to use an US‐responsible paclitaxel‐loaded microcapsules (PM) as the main content of balloon drug coating to enhance bioavailability of DCB.MethodsAn US‐controlled paclitaxel release balloon is designed and fabricated based on the US‐responsible paclitaxel‐loaded poly (lactic‐co‐glycolic acid) (PLGA) microcapsules. Rapid exchange percutaneous transluminal coronary angioplasty (PTCA) balloon catheters were coated with the PM. The deployment processes of the paclitaxel‐loaded microcapsules coated balloons (PMCB) under US, PMCB without US and a homogenous matrix of paclitaxel and iopromide coated balloon (PICB) were then placed in healthy and stent implanted porcine coronary arteries.ResultsIn vitro release assay demonstrated an ability of US (1 MHz, 1.22 W/cm2, 1 minute) to affect the release kinetics of paclitaxel from PM by inducing a 76 ± 5.4% increase in the rate of release. The paclitaxel content in target vessels are 203 ± 37 μg/g for PMCB under US, 85 ± 23 μg/g for PMCB without US, and 107 ± 31 μg/g for PICB 1‐hr post‐surgery. The availability of the drug for the PMCB reaches 27% under US.ConclusionsThe US‐controlled paclitaxel release balloon significantly improved the drug content of the target vessels in the porcine model.
Stereoselective Biotransformations of Cyclic Imines in Recombinant Cells of Synechocystis sp. PCC 6803
Authors: Büchsenschütz Hanna C. , Vidimce‐Risteski Viktorija , Eggbauer Bettina , Schmidt Sandy , Winkler Christoph K. , Schrittwieser Joerg H. , Kroutil Wolfgang , Kourist Robert 
Published: October 2019

AbstractLight‐driven biotransformations in recombinant cyanobacteria allow to employ photosynthetic water‐splitting for cofactor‐regeneration and thus, to save the use of organic electron donors. The genes of three recombinant imine reductases (IREDs) were expressed in the cyanobacterium Synechocystis sp. PCC 6803 and eight cyclic imine substrates were screened in whole‐cell biotransformations. While initial reactions showed low to moderate rates, optimization of the reaction conditions in combination with promoter engineering allowed to alleviate toxicity effects and achieve full conversion of prochiral imines with initial rates of up to 6.3 mM h−1. The high specific activity of up to 22 U gCDW−1 demonstrates that recombinant cyanobacteria can provide large amounts of NADPH during whole cell reactions. The excellent optical purity of the products with up to >99 %ee underlines the usefulness of cyanobacteria for the stereoselective synthesis of amines.
Fabrication of Bi2WO6/Cu/WO3 All‐Solid‐State Z‐Scheme Composite Photocatalyst to Improve CO2 Photoreduction under Visible Light Irradiation
Authors: Wen Teh Yee , Wei Goh Yien , Ying Kong Xin , Ng Boon‐Junn , Yong Siek‐Ting , Chai Siang‐Piao 
Published: October 2019

AbstractPhotocatalysis has been widely explored to alleviate the high atmospheric CO2 content by converting CO2 into energy‐rich fuels. Bi2WO6 shows great potential in photocatalysis due to its high chemical stability, non‐toxicity and appropriate band position. However, the CH4 yield from CO2 photoreduction over bulk Bi2WO6 is relatively low ascribed to its single‐component structure. Inspired by natural photosynthesis, Z‐scheme system with photosystem I (PS I)‐photosystem II (PS II) coupling via an electron mediator can improve charge separation and at the same time, renders large overpotential, attributed to the vectorial electron transfer from PS II to PS I. In this contribution, an all‐solid‐state Z‐scheme photocatalyst that is composed of 2D Bi2WO6 nanosheets coupled with WO3 along with the incorporation of copper foil sheet as the electron mediator is designed to improve the CO2 reduction efficiency. The Bi2WO6/Cu/WO3 composite demonstrated a remarkable CH4 yield of 8.80 μmol g−1catalyst over 8 hours of visible light illumination, which is superior to the Bi2WO6 standalone.