bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surveillance of low‐grade appendiceal mucinous neoplasms for progression to pseudomyxoma peritonei: Results from a structured surveillance programme
Authors: Hannan Enda , Roman Lorena Martin , O'Brien Lukas , Mueller Anna , Staunton Oonagh , Shields Conor , Aird John , Mulsow Jurgen 
Published: December 2024

AbstractAimLow‐grade appendiceal mucinous neoplasm (LAMN) of the appendix is a rare tumour that can progress to pseudomyxoma peritonei (PMP). There is a lack of standardization of surveillance following resection of LAMN as the progression rate to PMP is unclear. The aim of this study was to evaluate the rate of progression following resection of LAMN to PMP in a structured surveillance programme.MethodData for all patients referred for LAMN surveillance from 2013 to 2021 were retrospectively collected. The surveillance regime consisted of annual CT and tumour markers for a 5‐year period. Patients who progressed to PMP were identified.ResultsOf the patients enrolled in surveillance following appendicectomy and LAMN diagnosis (65.1% female, median age 56 years), 83 had completed at least 1 year of surveillance (median follow‐up 24 months). Of these, 6% (n = 5) showed disease progression during follow‐up. The median time to progression was 23 months. Survival analysis revealed no statistically significant difference in progression with regards to T staging (p = 0.39), margin positivity (p = 0.11) or appendiceal perforation (p = 0.26). No patients with Tis disease developed PMP. A statistically significant difference in progression was seen in patients with M1b staging (p = 0.021) and in those with mucin beyond the right iliac fossa at diagnosis (p = 0.04).ConclusionThe observed progression rate justifies the necessity of postappendicectomy surveillance in patients with LAMN, with the risk of progression being highest within the first 3 years of diagnosis. The described surveillance programme allows for early detection of subclinical progression to PMP.
Examining socio‐economic disparities among e‐cigarette users and cigarette smokers in three Canadian jurisdictions
Authors: MacDougall Sarah , Asbridge Mark 
Published: December 2024

AbstractIntroductionIt is well established that a gradient exists among cigarette smokers, such that smoking is more prevalent among individuals who are of lower socio‐economic status (SES). In this study, we examined whether a similar SES gradient exists among electronic cigarette (e‐cigarette) using youth and adults in three Canadian jurisdictions.MethodsA secondary analysis of data from Ontario, Quebec and Yukon respondents (n = 58,592) to the 2017–2018 Canadian Community Health Survey was conducted. Unadjusted and adjusted logistic regression models explored SES measures: total and relative household income, and education level, separately on use of e‐cigarettes or cigarettes in the past 30 days. Models adjusted for additional socio‐demographic and psychosocial covariates.ResultsA significant inverse SES gradient existed for cigarette smoking based on education and income variables, with higher education and income associated with decreasing consumption in a stepwise manner. No SES gradient was observed for e‐cigarettes.Discussion and ConclusionsWhile a robust SES gradient was observed among cigarette smokers, no gradient for e‐cigarette use was observed. Explanations for these findings may be linked to perceptions that e‐cigarettes are healthier, have convenient designs and appealing flavours, and less stigmatised. As more becomes known about potential harms from e‐cigarettes, effective interventions may be needed to prevent the emergence of a gradient that disproportionately affects those at lowest income and education levels. Continued monitoring of e‐cigarette use patterns across SES groups is necessary for public health.
The role of executive functioning in smoking cessation: A scoping review
Authors: Viola Nicole M. , Lundine Jennifer P. , Kirihara Sho , Nemeth Julianna 
Published: December 2024

AbstractIssuesCreating and implementing a plan to successfully quit smoking likely requires executive function (EF) skills such as inhibition, cognitive flexibility, attention and working memory. This scoping review consolidates the research evidence evaluating the role of EF in smoking cessation.ApproachFollowing the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses extension for Scoping Reviews (PRISMA‐ScR), researchers and a medical librarian searched PubMed, EMBASE, ERIC, CINAHL and PSYCINFO in June 2022, hand‐search in September 2022 using relevant MeSH terms, and an updated search was completed in August 2024.Key FindingsFifteen articles were included. Self‐regulation was the most frequently evaluated EF across all studies. Performance on measures of impulsivity was most frequently related to successful smoking cessation. Across studies, performance on measures in areas of attention, working memory, cognitive flexibility and higher‐level EF was variable as it relates to smoking cessation success. There was considerable variability in the measures used to evaluate EF and definitions of cessation success. Across studies, very little research evaluates higher‐level EF.Implications and ConclusionDifferences in EF and cessation measures make comparisons across studies difficult. Future work is needed utilising common assessment and outcome measures that will improve our understanding of the complex cognitive skills needed for successful cessation. Particular consideration should be given to higher‐level EFs including reasoning, planning, problem‐solving and decision‐making.
Efficacy and safety of switching to insulin glargine 300 U/mL in people with type 2 diabetes uncontrolled on basal insulin in China: A post hoc subpopulation analysis of the INITIATION study
Authors: Chen Liming , Wan Hailong , Han Jie , Yang Caixian , Shao Hailin , Li Jialin , Yan Wensheng , Xiao Jianzhong , Sun Yadong , Li Min , Han Yanfang , Kang Lei , Zhang Minlu 
Published: December 2024

AbstractAimsTo evaluate the efficacy and safety of insulin glargine 300 U/mL (Gla‐300) in people with uncontrolled type 2 diabetes (T2D) switching from another basal insulin (BI).Materials and MethodsINITIATION was an interventional, single‐arm, phase IV study conducted in China. In this post hoc subpopulation analysis, the efficacy and safety of switching to Gla‐300 was investigated in individuals with uncontrolled T2D (HbA1c 7.5%–11.0% [58–97 mmol/mol]) with previous BI. The primary endpoint was HbA1c change at week 24. Other measures of glycaemia, hypoglycaemia, insulin dose and weight change were assessed.ResultsThree hundred and two participants switched to Gla‐300 from another BI, including 232 from insulin glargine 100 U/mL (Gla‐100) and 55 from insulin degludec (IDeg). At week 24, the mean ± standard error (SE) HbA1c change from baseline was −0.87% ± 0.06% (−9.5 ± 0.7 mmol/mol; p <0.001). Significant reductions in fasting plasma glucose (least‐squares mean [LSM] change −1.13 mmol/L) and fasting self‐measured blood glucose (LSM change −1.36 mmol/L) were also observed (both p <0.001). The mean daily BI dose increased from 18.86 U (0.27 U/kg) at baseline to 28.83 U (0.41 U/kg) at week 24. During the 24‐week treatment period, the incidence of any hypoglycaemia was 43.8% for all hypoglycaemia and 15.1% for nocturnal hypoglycaemia; the incidence of severe hypoglycaemia was low (0.7%). Minimal body weight change was documented.ConclusionsGla‐300 improved glycaemic control with a relatively low hypoglycaemia risk and minimal weight gain in Chinese people with T2D uncontrolled on previous BI.
Single Coronary Origin From Right Coronary Sinus With Intraseptal Course: How to Make Diagnosis by Echocardiography
Authors: Cantinotti Massimiliano , Clemente Alberto , Capponi Guglielmo , Assanta Nadia 
Published: December 2024

ABSTRACTWe describe a rare case of a male adolescent with anomalous aortic origin of the left coronary artery from the right sinus with intraseptal course (L‐ACAO‐IS), which was diagnosed at transthoracic echocardiography. The case we presented confirms how echocardiography is accurate in the diagnosis of even challenging coronary artery origin anomalies such as L‐ACO‐IS. Coronary artery origin evaluation should be an integral part of echocardiography examinations in infants, children, and young adults, especially those undergoing physical activity. We also remark the importance of using multiple views including short axis, long axis, and modified (anteriorized) 4‐chamber view which is very helpful for a better evaluation of coronary artery origin and their proximal course.
Examining the potential involvement of NONO in TDP‐43 proteinopathy in Drosophila
Authors: Koch Rafael , Nagoshi Emi 
Published: December 2024

AbstractThe misfolding and aggregation of TAR DNA binding protein‐43 (TDP‐43), leading to the formation of cytoplasmic inclusions, emerge as a key pathological feature in a spectrum of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD). TDP‐43 shuttles between the nucleus and cytoplasm but forms nuclear bodies (NBs) in response to stress. These NBs partially colocalise with nuclear speckles and paraspeckles that sequester RNAs and proteins, thereby regulating many cellular functions. The laboratory of Steven Brown has recently found that the non‐POU domain‐containing octamer‐binding protein (NONO), a component of paraspeckles, forms novel nuclear speckle‐like structures in mouse cortical neurons in response to stress and sleep deprivation. These findings suggest the possibility of a functional link between NONO and TDP‐43, potentially contributing to TDP‐43 proteinopathy. Here, we demonstrate that pathological phenotypes caused by TDP‐43 gain of function—locomotor defects and life span shortening—are exacerbated by silencing the Drosophila homolog of NONO, no on or off transient A (NonA). Additionally, NonA silencing results in an increase in nuclear TDP‐43 NBs. These results provide supporting evidence for the functional link between NONO and TDP‐43 and lay the foundation for dissecting underlying mechanisms.
The stonesphere in agricultural soils: A microhabitat associated with rock fragments bridging rock and soil
Authors: Dittrich Felix , Klaes Björn , Brandt Luise , Groschopf Nora , Thiele‐Bruhn Sören 
Published: December 2024

AbstractRock fragments (RFs) are abundant soil constituents, but are routinely excluded from soil analyses. Hence, their contribution to soil properties, and in particular to the microbiome, is incompletely understood. Therefore, shifts in microbial colonisation along the rock‐to‐soil continuum of topsoils from three agricultural sites with different sedimentary parent rock materials were investigated with particular attention to RFs. Microbial biomass and community composition were quantified using phospholipid fatty acid (PLFA) analysis for unweathered and weathered parent rock materials, two RF fractions (8–16 mm and 2–8 mm) and the fine earth (FE; <2 mm). Trends in biogeochemical weathering, nutrient availability and soil organic matter (OM) development were assessed using mineralogical, geochemical and physical analyses. Actinobacterial PLFA was particularly abundant in parent rocks, where Actinobacteria likely contribute to rock weathering and the initiation of OM accumulation. Conversely, bacterial PLFAs were most abundant in the FE under nutrient‐ and OM‐rich conditions. The integral role of RFs as a microbial habitat is demonstrated by a distinct fungal colonisation, which is enabled by the specific physical features of RFs in combination with the provision of inorganic nutrients. Our findings indicate that RFs are colonised by microbes and that differences in the community structure depend on mineralogical properties and chemical weathering status. We document that RFs are microhabitats with a significant potential to host microbial life in cultivated soils, and thus, could play an important role in biogeochemical cycling and the provision of soil functions in agroecosystems.
Delineating vineyard management zones: Intrafield spatial variability of soil properties of carbonate vineyard soils
Authors: Eslava‐Lecumberri Francisco J. , Jiménez‐Ballesta Raimundo 
Published: December 2024

AbstractGrapevine (Vitis vinifera L.) is a traditional crop cultivated in Navarre (NE Spain). However, in some areas, it is grown without harnessing land suitability for its cultivation. This research was conducted to approach the pedological recognition of viticulture zoning (on the farm scale) in a traditional and distinct viticultural region: Olite (Navarre). As grape yield and grape quality in a given field are generally variable and do not coincide one way or another, 13 soil profiles were selected for pedological description and analysis in an attempt to recognise the importance of soil properties. For that purpose, 45 soil samples (corresponding to the different pedogenetic horizons of the 13 soil profiles) were collected to improve zonal vineyard estimations. The most notable characteristics of the studied soils were the presence of petrocalcic horizons, high stone fragments content, mainly loamy textures, high pH (between 8.24 and 9.24), high carbonate (between 19.1% and 90.0%), and active limestone contents (between 5.7% and 26.1%), and relatively low organic matter contents (<3.34%). Appreciable soil properties variability was detected from the results of this study and, therefore, variability in production and grape composition was expected. These results emphasise the spatial variability of the study area soils in a way that allows for the delineation of homogeneous viticultural zones. The results also provide the necessary information not only for viticultural zoning in the Navarre wine‐growing region, but also in wine‐growing regions with a Mediterranean continental climate. Hence, our findings will allow future viticultural management zones to be developed and specific practices to be implemented.
Experimental and Simulation Study on Fatigue Damage Characteristics of HNBR by HTHP Aging in Oil‐Based Mud Environment
Authors: Hu Gang , Deng Jie , Wang Guorong , Tang Kai , Ren Guohui , Wen Xinming 
Published: December 2024

ABSTRACTHydrogenated nitrile butyl rubber (HNBR) elastomers are widely used in high‐temperature and high‐pressure (HTHP) corrosive environments, especially in the oil and gas sector. However, fatigue failure, which is often encountered in rubber components, remains a critical issue. In this paper, the effect of HTHP aging on the fatigue damage characteristics of HNBR in an oil‐based mud environment is investigated through experiments and numerical simulations. The experimental results showed that the elongation at break of the specimens decreased by 260% and the compressive stiffness increased with strain after high‐temperature and high‐pressure exposure in the oil‐based mud. Furthermore, tear tests showed that the rate at which the aged HNBR produced unit crack surfaces was significantly accelerated. Finally, the fracture and fatigue crack extension simulation results show the similarity between the damage evolution law of HNBR materials and the stress–strain curve of typical rubber materials.
‘DIE MENSCHENRECHTE HABEN KEIN GESCHLECHT’: HEDWIG DOHM'S FEMINIST CONCEPTION OF HUMAN RIGHTS
Authors: Wogenstein Sebastian 
Published: December 2024

ABSTRACTThis article discusses Hedwig Dohm's (1831–1919) conceptualisation of women's rights as human rights. The focus is on Dohm's essays and the strategies she employs in dismantling the arguments of women's rights opponents. By casting women's rights as human rights, she links her claims back to earlier human rights declarations and demands that their implied universality be actualised regarding women. The article examines parody and satire as important tools in two of Dohm's works – ‘Was die Pastoren von den Frauen denken’ (1872) and Der Frauen Natur und Recht (1876) – in which Dohm exposes contradictions and logical flaws in antifeminist positions. In particular, she rejects the patriarchal notion that women are biologically determined to serve in certain professions and fulfil specific roles in society. When addressing religion, Dohm, who was Jewish by birth and identified as areligious, typically refers to Christianity, which appears in her writing primarily as a tool of oppression. Notably, Dohm shows how domination and oppression operate in multilayered ways, and this awareness of intersectionality allows her to situate the discussion of women's rights in a larger rights framework in which gender is interlinked with other factors that exacerbate oppression. The article concludes with the suggestion that the concept of ‘jurisgenerativity’, i.e. the generative effect of rights narratives on the normative universe, can capture the process by which words shape the normative foundations from which legal legitimacy emanates.
Liberatory Motherhood: A Framework & Praxis for Caring and Scholaring Otherwise in the Neoliberal Academy
Authors: Sicka Bhavika 
Published: December 2024

ABSTRACTThis article contributes to the emergent literature on motherhood in neoliberal higher education by proposing liberatory motherhood as a theoretical framework and praxis to deconstruct and reconstruct motherhood in the neoliberal academy. The author, an early‐career immigrant woman scholar of color, uses feminist autoethnography to critically examine the disempowering, disembodying, and departicularizing effects of neoliberal subjectivation on motheracademics, foregrounding her lived experiences of caregiving in her analysis. She approaches academic motherhood through a prismatic lens of a pluralistic feminist rhetorical analysis that emphasizes interrelationality, tracing her experiences of caring and producing otherwise as a way to signal opportunities to reembody motherhood in the academy. She finds mothering and othering to be mutually reinforcing in the academy and argues for rehumanizing care through alternative (re)productivity. She offers liberatory motherhood as an emancipated and emancipatory motherhood that draws from queer, decolonial, and other motherhoods, reflecting on its potential to further scholarship and practices geared toward reformulating academic subjectivities and emancipating the academy from coercions set by the market.
Repeated Radiosynovectomy in Haemophilia: Revealing Long‐Term Effectiveness and Safety
Authors: Koc Basak , Turkmen Cuneyt , Polat Gokhan , Zulfikar Bulent 
Published: December 2024

ABSTRACTIntroductionRadiosynovectomy (RS), which uses beta particle‐emitting radiocolloids, has proven highly effective in significantly reducing the occurrence of haemarthroses and breaking the cycle of bleeding and synovitis. This study now presents the long‐term outcomes of repeated RS in individuals with haemophilia.Materials and MethodsRepeated RS was administered to 48 joints in 37 people with haemophilia (PwHs) diagnosed with chronic haemophilic synovitis. The frequency of bleeding episodes was meticulously recorded during the 6‐month periods preceding and following each of the initial and subsequent RS procedures. Treatment failure was designated by the necessity for additional RS injections.ResultsThe results for 48 joints were analysed. The mean bleeding frequency of the joints was 12.5 ± 7.29 (median 10) within the last 6 months in the pre‐treatment evaluation and after the treatment, the mean bleeding frequency of the joints decreased to 2.25 ± 3.82 (median 0.5) for the first 6 months (p < 0.001) after the first RS. The mean survival of the first intervention was 40.52 ± 33.79 months (range, 1–124 months). In the second RS, the mean bleeding frequency of the joints was 10.29 ± 7.66 (median 8) within the last 6 months in the pre‐treatment evaluation and after the treatment, and the mean bleeding frequency of the joints decreased to 0.93 ± 1.69 (median 0) for the first 6 months (p < 0.001). The survival rate of the second RS was 94% at 12 months, and 87% at 36 months.ConclusionRepeated RS was proven to be an effective and safe treatment for Pwh with recurrent bleeding episodes during long‐term follow up. Thirty‐six months survival rate was 87% (42 of 48 joints).
Hepatolithiasis pathogenesis update
Authors: Lu Wei , Li Zhi‐Yuan , Yang Zhi‐Ming , Hao Jing‐Cheng 
Published: December 2024

AbstractHepatolithiasis is prevalent in East Asian countries and not common in Western countries. In recent years, because of the increased number of immigrants from East Asia in Western countries, hepatolithiasis has gradually become a global problem. Although current surgical interventions for hepatolithiasis boast a high rate of stone clearance, the persistent challenges of the disease's refractory nature and high recurrence rate continue to complicate its treatment. Therefore, understanding its underlying pathogenesis is meaningful for effective treatment. In this review, we discuss the common risk factors: infection, cholangitis, environmental factors and diet habits, abnormal bile components, anatomical abnormalities, and bile stasis, and summarize the relevant mechanisms.
Rheology and structure of ceramic stereolithography slurries: Role of powder nature, dispersant, and orthogonal strain
Authors: Fournier Sylvain , Chevalier Jérôme , Reveron Helen , Chèvremont William , Baeza Guilhem P. 
Published: December 2024

AbstractWe investigate the rheological properties of ceramic slurries designed for laser stereolithography manufacturing in relation to their formulation, including the powder morphology, their volume fraction, and the concentration of dispersing agent. By combining dynamic strain sweep and Small‐Angle X‐ray Scattering (SAXS) experiments, we first illustrate that slurry viscosity follows an exponential trend with increasing particles content, with steeper increase observed for more aggregated particles. We then show that increasing the dispersant concentration up to an optimal value decreases slurry viscosity, as SAXS measurements reveal a reduction and homogenization in agglomerate size. Finally, we evidence that applying vertical oscillatory deformation during steady shear flow induces fluidization of the slurry. The shear viscosity exhibits a time–strain rate equivalence, enabling the generalization of this effect across a wide range of formulations. This methodology holds potential for industrial applications, where introducing vibration perpendicular to the scraping blade motion could improve the surface quality of the spread slurry prior to polymerization.
Structural origin of anisotropic mechanical/thermal behavior in La2SrAl2O7 and Nd2SrAl2O7 perovskites
Authors: Liu Bin , Zhou Hui , Liu Yuchen , Li Shaoxun , Chu Kaili , Qu Zhixue , Li Wenxian , Li Yiran 
Published: December 2024

AbstractRare earth strontium aluminates have attracted much attention due to their excellent properties and widely functional applications. In this work, the bonding characteristics, mechanical/thermal properties, and phonon behavior of La2SrAl2O7 and Nd2SrAl2O7 with layered structure are investigated using first‐principles calculations. The weak chemical bonds within the rock‐salt layer lead to the anisotropy of elastic moduli, tensile, and shear strength, benefiting their damage tolerance. It is also found that the low‐frequency phonons present much lower scattering rates, making themselves vital contributors to heat conduction. Owing to the enhanced anharmonicity, Nd2SrAl2O7 exhibits lower thermal conductivity than La2SrAl2O7. Moreover, the lower thermal conductivities are observed along the z direction, which is attributed to the anisotropic chemical bonding. These results clarify the role of the weak bonds within layered structures in modulating their mechanical and thermal performance, which is expected to shield light on the development of perovskites with layered Ruddlesden–Popper structures.