bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of kidney function throughout the heart failure trajectory – a position statement from the Heart Failure Association of the European Society of Cardiology
Authors: Mullens Wilfried , Damman Kevin , Testani Jeffrey M. , Martens Pieter , Mueller Christian , Lassus Johan , Tang W.H. Wilson , Skouri Hadi , Verbrugge Frederik H. , Orso Francesco , Hill Loreena , Ural Dilek , Lainscak Mitcha , Rossignol Patrick , Metra Marco , Mebazaa Alexandre , Seferovic Petar , Ruschitzka Frank , Coats Andrew 
Published: January 2020

AbstractAppropriate interpretation of changes in markers of kidney function is essential during the treatment of acute and chronic heart failure. Historically, kidney function was primarily assessed by serum creatinine and the calculation of estimated glomerular filtration rate. An increase in serum creatinine, also termed worsening renal function, commonly occurs in patients with heart failure, especially during acute heart failure episodes. Even though worsening renal function is associated with worse outcome on a population level, the interpretation of such changes within the appropriate clinical context helps to correctly assess risk and determine further treatment strategies. Additionally, it is becoming increasingly recognized that assessment of kidney function is more than just glomerular filtration rate alone. As such, a better evaluation of sodium and water handling by the renal tubules allows to determine the efficiency of loop diuretics (loop diuretic response and efficiency). Also, though neurohumoral blockers may induce modest deteriorations in glomerular filtration rate, their use is associated with improved long‐term outcome. Therefore, a better understanding of the role of cardio–renal interactions in heart failure in symptom development, disease progression and prognosis is essential. Indeed, perhaps even misinterpretation of kidney function is a leading cause of not attaining decongestion in acute heart failure and insufficient dosing of guideline‐directed medical therapy in general. This position paper of the Heart Failure Association Working Group on Cardio‐Renal Dysfunction aims at improving insights into the interpretation of renal function assessment in the different heart failure states, with the goal of improving heart failure care.
Optimization of sorrel oil biodiesel production by base heterogeneous catalyst from kola nut pod husk: Neural intelligence‐genetic algorithm versus neuro‐fuzzy‐genetic algorithm
Authors: Betiku Eriola , Ishola Niyi B. 
Published: January 2020

AbstractThe conversion of sorrel oil to biodiesel through transesterification was conducted in the presence of calcined kola nut husk pod ash as a base heterogeneous catalyst. Thus, to predict the biodiesel production yield, two models based on neural intelligence and neuro‐fuzzy techniques were established. The predictive capability and accuracy of the models were compared using various statistics. The neuro‐fuzzy‐based model (adaptive neuro‐fuzzy inference system, ANFIS) obtained for the transesterification process had a lower (0.32%) mean relative percent deviation (MRPD) and a higher coefficient of determination—R2 (0.9991) compared to the neural intelligence‐based model (artificial neural network, ANN) with MRPD of 0.42% and R2 of 0.9971. Also, the models developed were coupled with genetic algorithm (GA) in order to maximize the sorrel oil biodiesel (SOB) yield at optimum values of the process input parameters. SOB yield of >99.0 wt% was obtained when both developed models were subjected to optimization. The results of the process modeling confirm that neuro‐fuzzy model performed slightly better than neural intelligence model. The sensitivity analysis performed on both models shows that reaction time was the most important input variable while other input variables could not be neglected. The characteristics of the synthesized SOB demonstrate that it satisfied the biodiesel standard limits.
A novel safety assurance method based on the compound equivalent modeling and iterate reduce particle‐adaptive Kalman filtering for the unmanned aerial vehicle lithium ion batteries
Authors: Wang Shunli , Fernandez Carlos , Fan Yongcun , Feng Juqiang , Yu Chunmei , Huang Kaifeng , Xie Wei 
Published: January 2020

AbstractThe safety assurance is very important for the unmanned aerial vehicle lithium ion batteries, in which the state of charge estimation is the basis of its energy management and safety protection. A new equivalent modeling method is proposed for the mathematical expression of different structural characteristics, and an improved reduce particle‐adaptive Kalman filtering model is designed and built, in which the incorporate multiple featured information is absorbed to explore the optimal representation by abandoning the redundant and abnormal information. And then, the multiple parameter identification is investigated that has the ability of adapting the current varying conditions, according to which the hybrid pulse power characterization test is accommodated. As can be known from the experimental results, the polynomial fitting treatment is carried out by conducting the curve fitting treatment and the maximum estimation error of the closed‐circuit‐voltage is 0.48% and its state of charge estimation error is lower than 0.30% in the hybrid pulse power characterization test, which is also within 2.00% under complex current varying working conditions. The iterate calculation process is conducted for the unmanned aerial vehicle lithium ion batteries together with the compound equivalent modeling, realizing its adaptive power state estimation and safety protection effectively.
Performance analysis of cooperative power‐line communication system with signal space diversity
Authors: Sikri Aman , Mathur Aashish , Srinivas K. V. 
Published: January 2020

AbstractPower‐line communication (PLC) is a cost‐effective and promising communication technology for many smart grid applications. However, the presence of additive and multiplicative power line noises deteriorate the performance of a PLC system. In this paper, we propose signal space diversity (SSD) technique for a cooperative PLC system. The additive PLC channel noise is assumed to be Bernoulli‐Gaussian–distributed. The multiplicative PLC channel noise gain is characterized by log‐normal distribution. The closed‐form expressions of the average symbol error rate (SER) and outage probability of cooperative PLC system with SSD have been derived in this paper. It has been shown that the proposed cooperative PLC system results in achieving better spectral efficiency, as well as the reliability of the received signal.
Continuous evaluation of participants’ perceptions of impact: Applying a boundary object in organizational‐level interventions
Authors: Ipsen Christine , Poulsen Signe , Gish Liv , Kirkegaard Marie Louise 
Published: January 2020

AbstractWorkplaces across Europe experience increasing problems with work‐related strain and stress. Consequently, they are confronted with the need for stress‐preventive interventions that target the sources of stress. A matter of current debate is how to continuously evaluate an organizational‐level intervention and gain insight into progress and participants’ perceptions of its impact; however, empirical data are lacking. Therefore, we conducted a qualitative study in three workplaces—two in information technology (IT) and one in manufacturing—to explore the design, evaluation process, perceived impact, and employees’ experiences with the continuous use of a physical evaluation tool (visualization object) during an organizational‐level intervention process. We conducted observations, surveys, semi‐structured interviews and chronicle workshops across all three workplaces. Overall, the results showed that the visualization object proved successful as a tool to explicate and combine participants’ perceptions of impact. The evaluation process also clarified that participants initially had different understandings of the intervention's purpose. However, the study also showed that the visualization object facilitated a dialog among participants, converging the different understandings to create a shared understanding and compliance of purpose. Finally, the respondents reported that the evaluation tool acted as a collective reminder of the intervention and the related changes. We conclude the study by providing recommendations for future evaluations of participatory organizational‐level interventions.
Do online applications for free assistive technology devices by individuals with disabilities introduce moral hazard? Evidence from Shanghai, China
Authors: Huang Xiaojing , Sun Mei , Song Yu , Li Chengyue , Jin Rong , Sun Heqi , Wang Weili , Zhang Qi , Lu Jun 
Published: January 2020

SummaryObjectivesTo examine whether moral hazard may exist under unsupervised home‐based online applications, leading to more assistive technology devices (ATDs) and larger per capita expenditures on ATDs than under supervised community center–based online applications.MethodsUsing the data from the Assistive Devices Resource Centre in Shanghai, descriptive statistics were estimated for the sociodemographics of applicants. Multiple linear regression and logistic regression were used to test the effect of the introduction of home‐based online applications.ResultsIn 2015‐2016, there were marked increases of 22.3% in the total number of ATDs and 27.2% in the total expenditure on ATDs compared with 2013‐2014. The per capita number and expenditure also demonstrated an increasing trend. More devices were applied for in 2015‐2016 than in 2013‐2014, yielding a higher expenditure per capita (P < .001). Interestingly, with an invisible price, more devices were applied for at home than in community centers (P < .001), but the expenditure per capita was smaller (P < .001).ConclusionsThe introduction of online applications increased the number of ATDs per capita. The home‐based applications induced the purchase of more ATDs but not higher expenditures on ATDs. Individuals with disabilities tend to request the maximum number of ATDs allowed by the application rules, which is an indicator of moral hazard. The prices of ATDs were not visible for individuals with disabilities, which may cause individuals to order costlier ATDs when applying at home. Stricter review may be needed to reign in the potential moral hazard among online applicants with disabilities.
Review of Computational Studies of NCM Cathode Materials for Li‐ion Batteries
Authors: Chakraborty Arup , Kunnikuruvan Sooraj , Dixit Mudit , Major Dan T. 
Published: January 2020

AbstractLithium‐ion based rechargeable batteries are considered among the most promising battery technologies because of the high energy‐ and power‐densities of these electrochemical devices. Computational studies on lithium ion batteries (LIBs) facilitate rationalization and prediction of many important experimentally observed properties, including atomic structure, thermal stability, electronic structure, ion diffusion pathways, equilibrium cell voltage, electrochemical activity, and surface behavior of electrode materials. In recent years, Ni, Co and Mn‐based (NCM) layered transition metal oxide positive electrode materials (LiNi1‐x‐yCoxMnyO2) have shown tremendous promise for high‐energy density LIBs, and these NCM‐based batteries are effectively commercialized. Here, we present an overview of recent theoretical work performed using first principles density functional theory on these layered cathode materials. This short review focuses on recent computational efforts of popular NCMs with increasing Ni content, ranging from NCM333 to NCM811.
High‐resolution 3D imaging of microvascular architecture in human glioma tissues using X‐ray phase‐contrast computed tomography as a potential adjunct to histopathology
Authors: Zhang Wenxue , Jian Jianbo , Sun Cuiyun , Chen Jie , Lv Wenjuan , Sun Mengyu , Zhao Yuqing , Zhao Qi , Hu Chunhong 
Published: January 2020

AbstractGliomas are rich in blood vessels, and the generation of tumor‐associated vessels plays an important role in glioma growth and transfer. Histology can directly depict microvascular architecture in the tumor, but it just provides two‐dimensional (2D) images obtained by destroying three‐dimensional (3D) tissue specimens. There is a lack of high‐resolution 3D imaging methods for observing the microvasculature throughout the entire specimens. X‐ray phase‐contrast computed tomography (PCCT) which is an emerging imaging method has demonstrated its outstanding potential in imaging soft tissues. Thus, this study aims to evaluate the potential of PCCT as an adjunct to histopathology in nondestructive and 3D visualization of the microvascular architecture in human glioma tissues. In this study, seven resected glioma tissues were scanned via PCCT and then processed histologically. The obtained PCCT data was analyzed and compared with corresponding histological results. Significant anatomical structures of the glioma such as microvessels, thrombi inside the microvessels, and areas of vascular proliferation could be clearly presented via PCCT, confirmed by the histological findings. Moreover, PCCT data also provided additional 3D information such as morphological alterations of the microvasculature, 3D distribution of the thrombi and stenosis severity of the vessels in glioma tissues, which cannot be fully analyzed in 2D histological slices. In conclusion, this study demonstrated that PCCT can offer excellent images at a near‐histological level and additional valuable information in screening gliomas, without impeding further histological investigations. Thus, this technique could be potentially used as an adjunct to conventional histopathology in 3D nondestructive characterization of glioma vasculature.
X-Linked Hypophosphatemia: Uniquely Mild Disease Associated With PHEX 3′-UTR Mutation c.*231A&gt;G (A Retrospective Case–Control Study)
Authors: Smith Pamela S , Gottesman Gary S , Zhang Fan , Cook Fiona , Ramirez Beatriz , Wenkert Deborah , Wollberg Valerie , Huskey Margaret , Mumm Steven , Whyte Michael P 
Published: January 2020

ABSTRACT
X-linked hypophosphatemia (XLH), the most prevalent heritable renal phosphate (Pi) wasting disorder, is caused by deactivating mutations of PHEX. Consequently, circulating phosphatonin FGF23 becomes elevated and hypophosphatemia in affected children leads to rickets with skeletal deformity and reduced linear growth while affected adults suffer from osteomalacia and forms of ectopic mineralization. In 2015, we reported uniquely mild XLH in six children and four of their mothers carrying the non-coding PHEX 3′-UTR mutation c.*231A&gt;G. Herein, we characterize this mild XLH variant by comparing its features in 30 individuals to 30 age- and sex-matched patients with XLH but without the 3′-UTR mutation. The “UTR” and “XLH” groups, both comprising 17 children (2 to 17 years, 3 girls) and 13 adults (23 to 63 years, 10 women), had mean ages of 23 years. Only 43% of the UTR group versus 90% of the XLH group had received medical treatment for their disorder, including 0% versus 85% of the females, respectively (ps &lt; .0001). The UTR group was taller: mean ± SD height Z-score (HZ) −1.0 ± 1.0 versus −2.0 ± 1.4 (p = .0034), with significantly greater height for females (−0.9 ± 0.7 versus −2.3 ± 1.4; p = .0050) but not males (−1.2 ± 1.1 versus −1.9 ± 1.5; p = .1541), respectively. Mean ± SD “arm span Z-score” (AZ) did not differ between the UTR −0.8 ± 1.3 versus XLH −1.3 ± 1.8 groups (p = .2269). Consequently, the UTR group was more proportionate with a mean ∆Z (AZ – HZ) of 0.1 ± 0.6 versus 0.7 ± 1.0 (p = .0158), respectively. Compared to the XLH group, the UTR group had significantly higher fasting serum Pi and renal tubular threshold maximum for phosphorus per glomerular filtration rate (TmP/GFR) (ps ≤ .0060), serum FGF23 concentrations within the reference range (p = .0068), and similar serum alkaline phosphatase levels (p = .6513). UTR lumbar spine bone mineral density Z-score was higher (p = .0343). Thus, the 3′-UTR variant of XLH is distinctly mild, especially in girls and women, posing challenges for its recognition and management. © 2020 American Society for Bone and Mineral Research.
MiR‐145 inhibits the migration and invasion of papillary thyroid carcinoma cells through NF‐κB pathway regulation
Authors: Chen Gengyu , Gao Ying , Wang Gangpu , Dai Guofeng , Tong Li 
Published: January 2020

AbstractPapillary thyroid carcinoma (PTC) is the most prevalent cancer in the endocrine system, and the number of patients diagnosed with PTC has been increasing rapidly in recent years. Previous studies have reported that miR‐145 plays an important role in many kinds of cancers, but its function in PTC remains unclear. In this study, we found that compared to paracancerous tissues, the level of miR‐145 expression was significantly downregulated in PTC tissues. When miR‐145 is overexpressed, migration and invasion of PTC cells were suppressed in vitro. In addition, we found that miR‐145 downregulated the nuclear factor‐κB (NF‐κB) pathway in PTC cells. Taken together, our data suggest that miR‐145 functions as a tumor suppressor in PTC with the suppressive effect related to downregulation of the NF‐κB pathway.
Long non‐coding RNAE330013P06 promotes progression of breast cancer with type 2 diabetes
Authors: Chen Runqi , Shi Pengcheng , Zhang Yan , Wu Haiming , Li Xiaoping , Yang Wengfu , Luo Fei , JinmingXue  , Yao Liang , Yang Jun , Wang Wangfu , Zhang Bo , Li Peng , Miao Yongmin , Wang Qianjun , Tian Fuguo 
Published: January 2020

AbstractBackgroundIn previous research, we found diabetes rather than obesity was an independent risk factor of breast cancer. However, why diabetes could lead to increased risk of breast cancer patients remains elusive. Long non‐coding RNAE330013P06 has been shown to be upregulated in diabetes, and long non‐coding RNAs generally promote progression of cancer.MethodsAbout 200 specimens of breast patients were obtained in previous clinical trial; 34 samples diagnosed as type 2 diabetes in breast cancer patient were enrolled in this research. Blood samples from 36 patients diagnosed as breast cancer without diabetes; 35 diabetic patients and 35 healthy peoples were obtained as control. All blood samples were measured by quantitative real‐time PCR (qRT‐PCR). Invasion and migration were tested by Transwell assay. Cell proliferation assay was tested by CCK‐8. Protein analysis was determined by Western blot.ResultsCompared with breast cancer patients without diabetes, diabetic patients without breast cancer and healthy peoples, LncRNAE330013P06 was upregulated in breast cancer patient with diabetes. Furthermore, of 34 breast patients, high LncRNAE330013P06 expression was significantly associated with family history, tumor‐node‐metastasis stage and lymph node metastasis. E33 promoted cancer cell growth in vitro via downregulation of P53.ConclusionUpregulation of LncRNAE330013P06 driven by type 2 diabetes is one of the factors which promoted progression of breast cancer.
Evaluation of neutrophil extracellular traps as the circulating marker for patients with acute coronary syndrome and acute ischemic stroke
Authors: Lim Hyeon‐Ho , Jeong In‐Hwa , An Gyu‐Dae , Woo Kwang‐Sook , Kim Kyeong‐Hee , Kim Jeong‐Man , Yun Seong‐Hoon , Park Joo‐In , Cha Jae‐Kwan , Kim Moo‐Hyun , Han Jin‐Yeong 
Published: January 2020

AbstractIntroductionNeutrophil extracellular traps (NETs) are known to be induced by various factors. In this study, we tried to identify circulating levels of NETs in patients with acute coronary syndrome (ACS) and acute ischemic stroke (AIS) and to confirm its suitability as a new circulating marker in their detection.MethodsWe prospectively enrolled 95 patients with a diagnosis of ACS (N = 37) or AIS (N = 58) in Dong‐A University Hospital, Busan, Korea. The control group was selected from healthy adults (N = 25) who visited the hospital for health screening. Circulating levels of NETs were evaluated by measuring plasma concentrations of double‐stranded DNA (dsDNA) and DNA‐histone complex.ResultsThe concentrations of dsDNA were statistically higher in patients with ACS or AIS than those in the control group (both P < .001). In the univariable and multivariable analyses, statistically significant risk factors were troponin I (TnI) level and dsDNA concentration in the ACS group (P = .046 and P = .015, respectively) and only dsDNA concentration in the AIS group (P = .002). In the receiver operating characteristic curve analyses, the area under the curve values for TnI level and dsDNA concentration in the ACS group were 0.878 and 0.968, respectively, and the value for dsDNA concentration in the AIS group was 0.859.ConclusionsIn this study, it was confirmed that the circulating level of NETs was increased in patients with ACS and AIS at initial presentation. Findings in this study show that NETs could be used as a new circulating marker for the initial diagnosis of ACS or AIS.
Ezh2‐dependent H3K27me3 modification dynamically regulates vitamin D3‐dependent epigenetic control of CYP24A1 gene expression in osteoblastic cells
Authors: Moena Daniel , Nardocci Gino , Acevedo Elvis , Lian Jane , Stein Gary , Stein Janet , Montecino Martin 
Published: January 2020

AbstractEpigenetic control is critical for the regulation of gene transcription in mammalian cells. Among the most important epigenetic mechanisms are those associated with posttranslational modifications of chromosomal histone proteins, which modulate chromatin structure and increased accessibility of promoter regulatory elements for competency to support transcription. A critical histone mark is trimethylation of histone H3 at lysine residue 27 (H3K27me3), which is mediated by Ezh2, the catalytic subunit of the polycomb group complex PRC2 to repress transcription. Treatment of cells with the active vitamin D metabolite 1,25(OH)2D3, results in transcriptional activation of the CYP24A1 gene, which encodes a 24‐hydroxylase enzyme, that is, essential for physiological control of vitamin D3 levels. We report that the Ezh2‐mediated deposition of H3K27me3 at the CYP24A1 gene promoter is a requisite regulatory component during transcriptional silencing of this gene in osteoblastic cells in the absence of 1,25(OH)2D3. 1,25(OH)2D3 dependent transcriptional activation of the CYP24A1 gene is accompanied by a rapid release of Ezh2 from the promoter, together with the binding of the H3K27me3‐specific demethylase Utx/Kdm6a and thereby subsequent erasing of the H3K27me3 mark. Importantly, we find that these changes in H3K27me3 enrichment at the CYP24A1 gene promoter are highly dynamic, as this modification is rapidly reacquired following the withdrawal of 1,25(OH)2D3.