bluuebunny/crossref_metadata_2025_split huggingface dataset:
MassARRAY-based single nucleotide polymorphism analysis in breast cancer of North Indian Population.
Authors: Bakshi Divya , Nagpal Ashna , Sharma Varun , Sharma Indu , Shah Ruchi , Sharma Bhanu , Bhat Amrita , Verma Sonali , Bhat Gh. Rasool , Abrol Deepak , Sharma Rahul , Vashnavi Samantha , Kumar Rakesh 
Published: September 2020

Abstract
Background Breast Cancer (BC) is associated with inherited gene mutations. High throughput genotyping of BC samples has led to the identification and characterization of biomarkers for the diagnosis of BC. The most common genetic variants studied are SNPs (Single Nucleotide Polymorphisms) that determine susceptibility to an array of diseases thus serving as a potential tool for identifying the underlying causes of breast carcinogenesis. Methods SNP genotyping employing the Agena MassARRAY offers a robust, sensitive, cost-effective method to assess multiple SNPs and samples simultaneously. In this present study, we analyzed 15 SNPs of 14 genes in 550 samples (150 cases and 400 controls). We identified four SNPs of genes TCF21, SLC19A1, DCC, and ERCC1 showing significant association with BC in the population under study. Results The SNPs were rs12190287 (TCF21) having OR 1.713 (1.08-2.716 at 95% CI) p-value 0.022 (dominant), rs1051266 (SLC19A1) having OR 3.461 (2.136-5.609 at 95% CI) p-value 0.000000466 (dominant), rs2229080 (DCC) having OR 0.6867 (0.5123 -0.9205 at 95% CI) p-value 0.0116 (allelic) and rs2298881 (ERCC1) having OR 0.669 (0.46-0.973 at 95% CI), p-value 0.035 (additive) respectively. The in-silico analysis was further used to fortify the above findings. Conclusion It is further anticipated that the variants should be evaluated in other population groups that may aid in understanding the genetic complexity and bridge the missing heritability.
Nutritional and Inflammatory Measures Predict Survival of Patients with Stage IV Colorectal Cancer
Authors: Takamizawa Yasuyuki , Shida Dai , Boku Narikazu , Nakamura Yuya , Ahiko Yuka , Yoshida Takefumi , Tanabe Taro , Takashima Atsuo , Kanemitsu Yukihide 
Published: September 2020

Abstract
Background: This study aimed to evaluate the prognostic impact of nutritional and inflammatory measures (controlling nutritional status (CONUT) score, prognostic nutritional index (PNI), and modified Glasgow prognostic score (mGPS)) on overall survival (OS) in patients with stage IV colorectal cancer (CRC).Methods: Subjects were 996 patients with stage IV CRC who were referred to the National Cancer Center Hospital between 2001 and 2015. We retrospectively investigated correlations between OS and CONUT score, PNI, and mGPS. Multivariate analyses were performed using Cox proportional hazards regression models.Results: After adjusting for known factors (age, gender, BMI, ECOG performance status, location of primary tumor, CEA levels, histological type, M category, and prior surgical treatment), all three measures were found to be independent prognostic factors for OS in patients with stage IV CRC (CONUT score, p<0.001; PNI, p<0.001; mGPS, p<0.001). Significant differences in OS were found between low CONUT score (0/1) (n=614; 61%) and intermediate CONUT score (2/3) (n=276; 28%) (hazard ratio (HR)=1.20, 95% confidence interval (CI): 1.02-1.42, p=0.032), and intermediate CONUT score and high CONUT score (≥4) (n=106; 11%) (HR=1.30, 95% CI: 1.01-1.67, p=0.045). Significant differences in OS were found between mGPS=0 (n=633; 64%) and mGPS=1 (n=234; 23%) (HR=1.84, 95% CI: 1.54-2.19, p<0.001), but not between mGPS=1 and mGPS=2 (n=129; 13%) (HR=1.12, 95% CI: 0.88-1.41, p=0.349). Patients with low PNI (<48.0) (n=443; 44%) showed a significantly lower OS rate than those with high PNI (≥48.0) (n=553; 56%) (HR=1.39, 95% CI: 1.19-1.62, p<0.001).Conclusions: CONUT score, PNI, and mGPS were found to be independent prognostic factors for OS in patients with stage IV CRC, suggesting that nutritional and inflammatory status is a useful host-related prognostic indicator in stage IV CRC.
Differences between encoding and retrieval failure in mild cognitive impairment: results from quantitative electroencephalography and magnetic resonance volumetry
Authors: Han Su-Hyun , Pyun Jungmin , Yeo Soeun , Kang Dong Won , Jeong Ho Tae , Kang Seung Wan , Kim SangYun , Youn Young Chul 
Published: September 2020

Abstract
Background: The memory impairments in mild cognitive impairment (MCI) can be classified into encoding (EF) and retrieval (RF) failure, which can be affected by underlying pathomechanism. We explored the differences structurally and functionally.Methods: We compared quantitative electroencephalography (qEEG) power spectra and connectivity between 87 MCI patients with EF and 78 MCI with RF using iSyncBrain ™ (iMediSync, Inc., Korea) (https://isyncbrain.com/). Voxel-based morphometric analysis of the gray matter (GM) in the MCI groups and 71 cognitive normal controls were also done using the Computational Anatomy Toolbox 12 (http://www.neuro.uni-jena.de/cat/).Results: qEEG showed higher frontal theta and lower beta2 band power and higher theta and lower beta connectivity in the EF. There was no statistically significant difference in GM volume between the EF and RF. However, when compared to normal control, GM volume reductions due to EF in the left thalamus and bilateral hippocampi and reductions due to RF in the left thalamus, right superior frontal lobe, right superior temporal lobe, and right middle cingulum were observed ( p < 0.05, family-wise error correction). Conclusions: MCI differs functionally and structurally according to their specific memory impairments. The EF findings are structurally and functionally more consistent with the prodromal Alzheimer's disease stage than the RF findings. Since this study is a cross-sectional study, prospective follow-up studies are needed to investigate whether different types of memory impairments can predict the underlying pathology of amnestic MCI. Additionally, insufficient sample size may lead to ambiguous statistical findings in direct comparisons, a larger patient cohort could more robustly identify differences in GM volume reductions between the EF and the RF group.
Ten years of research and publications about hospice and palliative care in Mainland China: a bibliometric study
Authors: Jin Shuang , Liu Shuo , Li Jiaojiao , Ning Xiaohong , Liu Xiaohong 
Published: September 2020

Abstract
Background

Research is a fundamental element in the sustainable development of hospice and palliative care. Mainland China is facing increasing demand for hospice and palliative care and has launched related policies over the past decade. However, the state of research and publications in this field in China remains largely unknown. This study aimed to provide an overall picture of hospice-and palliative care -related research and publications in Mainland China from 2010 to 2019.

Methods

We searched Web of Science, Scopus, PubMed, CINAHL, OVID, and China National Knowledge Infrastructure for hospice-and palliative care -related publications in English and Chinese for 2010–2019. We analyzed the production, citations and impacts, publishing journals, region and institution of origin, and themes and active topics.

Results

A total of 3224 publications were identified, and 636 of them were considered of high quality. The production and impacts showed a clear increase—especially after 2016. However, the regional disparity between East and Western China in production was conspicuous and closely linked to economic factors. Beijing and Shanghai were the most productive regions. The hospice providers in the first five pilot regions had no collaboration with leading universities in their publications. Hospice and palliative care for cancer patients was the most common publication topic; some essential themes were rarely explored.

Conclusion

Research and publications of hospice and palliative care in Mainland China is developing faster than before; however, it remains at an early stage and should be promoted in terms of interregional equity. Collaboration among different disciplines, institutes, and regions should be encouraged.
The interaction between TERT promoter mutation and MGMT promoter methylation on overall survival of glioma patients: a meta-analysis
Authors: Vuong Huy Gia , Nguyen Thu Quynh , Ngo Tam N.M , Nguyen Hoang Cong , Fung Kar-Ming , Dunn Ian F. 
Published: September 2020

Abstract
Background There are controversial results concerning the prognostic implication of TERT promoter mutation in glioma patients concerning MGMT status. In this meta-analysis, we investigated whether there are any interactions of these two genetic markers on the overall survival (OS) of glioma patients. Methods Electronic databases including PubMed and Web of Science were searched for relevant studies. Hazard ratio (HR) and its 95% confidence interval (CI) for OS adjusted for selected covariates were calculated from the individual patient data (IPD), Kaplan-Meier curve (KMC), or directly obtained from the included studies. Results A total of nine studies comprising 2819 glioma patients were included for meta-analysis. Our results showed that TERT promoter mutation was associated with a superior outcome in MGMT-methylated gliomas (HR = 0.73; 95% CI = 0.55-0.98; p-value = 0.04), whereas this mutation was associated with poorer survival in gliomas without MGMT methylation (HR = 1.86; 95% CI = 1.54-2.26; p-value < 0.001). TERT-mutated glioblastoma (GBM) patients with MGMT methylation benefited from temozolomide (TMZ) treatment (HR = 0.33; 95% CI = 0.23-0.47; p-value < 0.001). MGMT methylation was not related with any improvement in OS in TERT-wild type GBMs (HR = 0.80; 95% CI = 0.56-1.15; p-value = 0.23).ConclusionsThe prognostic value of TERT promoter mutation may be modulated by MGMT methylation status. Not all MGMT-methylated GBM patients may benefit from TMZ; it is possible that only TERT-mutated GBM with MGMT methylation, in particular, may respond.
Continuous Block at the Proximal End of the Adductor Canal Provides Better Analgesia Compared to that at the Middle of the Canal After Total Knee Arthroplasty: A Randomized, Double-blind, Controlled Trial
Authors: Fei Yuda , cui xulei , Chen Shaohui , Peng Huiming , Feng Bin , Qian Wenwei , Lin Jin , Weng Xisheng , Huang Yuguang 
Published: September 2020

Abstract
Background: The optimal position for continuous adductor canal block (ACB) for analgesia after total knee anthroplasty (TKA) remians controversial, mainly due to high variability in the localization of the the adductor canal (AC). Latest neuroanatomy studies show that the nerve to vastus medialis plays an important role in innervating the anteromedial aspect of the knee and dives outside of the exact AC at the proximal end of the AC. Therefore, we hypothesized that continuous ACB at the proximal end of the exact AC could provide a better analgesic effect after TKA compared with that at the middle of the AC (which appeared to only block the saphenous nerve). Methods: Sixty-two adult patients who were scheduled for a unilateral TKA were randomized to receive continuous ACB at the proximal end or middle of the AC. All patients received patient-controlled intravenous analgesia with sufentanil postoperatively. The primary outcome measure was cumulative sufentanil consumption within 24 h after the surgery, which was analyzed using Mann-Whitney U tests. P-values <0.05 (two-sided) were considered statistically significant. The secondary outcomes included postoperative sufentanil consumption at other time points, pain at rest and during passive knee flexion, quadriceps motor strength, and other recovery related paramaters.Results: Sixty patients eventually completed the study (30/group). The 24-h sufentanil consumption was 0.22 µg/kg (interquartile range [IQR]: 0.15–0.40 µg/kg) and 0.39 µg/kg (IQR: 0.23–0.52 µg/kg) in the proximal end and middle groups (P = 0.026), respectively. There were no significant inter-group differences in sufentanil consumption at other time points, pain at rest and during passive knee flexion, quadriceps motor strength, and other recovery related paramaters. Conclusions: Continuous ACB at the proximal end of the AC has a better opioid-sparing effect without a significant influence on quadriceps motor strength compared to that at the middle of the AC after TKA.These findings indicates that a true ACB may not produce the effective analgesia, instead, the proximal end AC might be a more suitable block to alleviate pain after TKA.Trial registration: This study was registered at ClinicalTrials.gov (NCT03942133; registration date: May 06, 2019; enrollment date: May 11, 2019).
Relationship between Household Food Insecurity and Food and Nutrition Literacy among Children of 9-12 years of age: a cross-sectional study in a city of Iran
Authors: Rouz Fatemeh Khorram , Doustmohammadian Azam , Eslami Omid , Khadem-Rezaiyan Majid , Pourmohammadi Parisa , Amini Maryam , Khosravi Maryam 
Published: September 2020

Abstract
ObjectiveThe aim of this study was to assess the relationship between household food insecurity (HFI) with food and nutrition literacy (FNLIT) in a sample of Iranian children. This cross sectional study was performed on 315 children aged 9 to 12 years recruited from the primary schools throughout Mashhad, Iran. The Household Food Insecurity Access Scale (HFIAS) was used to assess the HFI. Also, overall FNLIT score and its sub-categories were evaluated using a validated 40-item questionnaire.Results The prevalence of HFI in the total sample was about 56 %. Also, almost 14 % of students had a low FNLIT score. Food insecure children had significantly lower levels of FNLT and some subscales including nutrition knowledge, food choice literacy, and food label literacy than the food-secure subjects, moreover, they had a higher likelihood of having low FNLIT score (OR = 2.89, CI: 1.03-8.09; p = 0.04). In conclusion, there is a negative association between HFI and FNLIT in children. Further studies to confirm this finding are needed.
Elevated serum triglyceride predicates recurrence of colorectal polyps in patients with advanced adenomas
Authors: Liu Boying , Wen Pingwu , Gu Xiaodong , Weng Ruiqiang , Liu Sudong 
Published: September 2020

Abstract
Background: Recurrence of colorectal polyps is common and impacted by various factors. This study was performed to explore the association between lipid profiles and recurrence of colorectal polyps. Methods: This study retrospectively analyzed the lipid profiles of 435 patients who underwent colonoscopy with removal of colorectal polyps and assessed recurrence of polyps by follow-up colonoscopy. Multivariate regression logistic analysis was used to evaluate the association between lipid profiles and polyp recurrence. Results: During the 1.5-year follow-up, recurrence of colorectal polyps was observed in 135 of 435 patients (30.34%). Patients with recurrent polyps showed a higher level of triglycerides ( P = 0.006) and lower levels of high-density lipoprotein cholesterol ( P = 0.008) and apolipoprotein A1 ( P = 0.033). The multivariate regression logistic model suggested that an elevated triglyceride level was an independent risk factor for polyp recurrence (odds ratio, 1.55; 95% confidence interval, 1.02 - 2.35; P = 0.039) in patients with advanced adenoma. Conclusions: Lipid profiles are associated with recurrence of colorectal polyps. An elevated triglyceride level is an independent risk predictor of polyp recurrence in patients with advanced adenoma. Keywords: Colorectal polyp, Recurrence, Lipid profile, Triglyceride, Risk factor.
Echo Simulation of Dual Polarization Doppler Weather Radar Based on the Physical Model
Authors: JieLa Qutie , Wang Haijiang , Hu Shipeng , Zhu Jiahui , Gao Mengqing 
Published: September 2020

Abstract
Using the scattering characteristics of particles to simulate the radar echo can supply the test signals close to the real precipitation echo for the weather radar, and save the time and cost of the research and development and maintenance of the weather radar. In this paper, the precipitation echo of weather radar is simulated based on the theoretical basis that the falling raindrops have a shape well approximated by an oblate spheroid in the atmosphere. The Marshal-Palmer distribution is applied to describe the raindrop spectrum distribution of precipitation particles. It is assumed that the raindrop particles of different sizes have the random distribution in the radar resolution volume, and then the spatial distribution of precipitation particles in the resolution volume is modeled. The echo signals of horizontal and vertical polarization channels of dual polarization weather radar are obtained by vector superposition of backscattering echoes of each particle. The experimental results show that this method can describe the microphysical characteristics of precipitation particles more completely and can be used to test the signal processing module of dual polarization Doppler weather radar.
Large autologous ilium with periosteum for tibiotalar joint reconstruction in Rüedi-Allgöwer III or AO/OTA type C3 pilon fractures
Authors: Li Dong , Li Jiao Jiao , Zhu Yuanyuan , Hou Fushan , Li Yuan , Zhao Bin , Wang Bin 
Published: September 2020

Abstract
Background: Management of Rüedi-Allgöwer III or AO/OTA type C3 pilon fracture presents numerous challenges to the orthopaedic surgeon. A joint preservation technique using a large autologous ilium with periosteum in combination with internal implant fixation was reported to improve the outcome of reconstruction. Methods: Twenty-five patients according to Tscherne/Oestern FxCO-I closed fracture and FxOI open fractures classification after Rüedi-Allgöwer III or AO/OTA type C3 pilon fracture received a large autologous ilium with periosteum for tibiotalar joint reconstruction and open reduction and internal fixation (ORIF), between March 2015 and September 2018. The visual analog scale (VAS), American Orthopaedic Foot & Ankle Society (AOFAS) score, and Burwell and Charnley criteria were used for outcome analysis. Results: Twenty patients with an average age of 45.2 years were followed for an average of 18.3 months. The VAS and AOFAS scores, and Burwell and Charnley ratings were recorded at the last follow-up after reconstructive surgery. Two patients developed redness and swelling at the wound site, but recovered after local care and dressing changes. No patient displayed deep surgical site infection, donor site complication, non-union or local complication during the final follow-up. The average bone union time was 18.3 months (range 3-36). Conclusions: Large autologous ilium with periosteum in combination with ORIF can be performed for tibiotalar joint reconstruction. This procedure reduces the risk of post-operative complications following articular reconstruction for Rüedi-Allgöwer III or AO/OTA type C3 pilon fractures in short follow-up.Level of Evidence: Level III, retrospective cohort study
Association between polypharmacy and the persistence of delirium: a retrospective cohort study
Authors: Kurisu Ken , Miyabe Daisuke , Furukawa Yoshiko , Shibayama Osamu , Yoshiuchi Kazuhiro 
Published: September 2020

Abstract
Background: Although the association between polypharmacy and the occurrence of delirium has been well studied, the influence of polypharmacy on the persistence of delirium remains unclear. We aimed to explore the effect of polypharmacy on the persistence of delirium.Methods: This retrospective cohort study was conducted at a tertiary hospital. The medical records of patients diagnosed with delirium who were referred to the Department of Psychosomatic Medicine were reviewed. Presentation with delirium on day 3 was set as the outcome in this study. We counted the number of drugs prescribed on the date of referral, excluding general infusion fluids, nutritional or electrolytic products, and psychotropics. To define polypharmacy, we developed a classification and regression tree (CART) model and drew a receiver operating characteristic (ROC) curve. The odds ratio (OR) of polypharmacy for the persistence of delirium on day 3 was calculated using a logistic regression model with the propensity score as a covariate.Results: We reviewed the data of 113 patients. The CART model and ROC curve indicated an optimal polypharmacy cutoff of six drugs. Polypharmacy was significantly associated with the persistence of delirium both before [OR, 3.02; 95% confidence interval (CI), 1.39–6.81; P = 0.0062] and after (OR, 3.19; 95% CI, 1.32–8.03; P = 0.011) propensity score adjustment.Conclusion: We discovered an association between polypharmacy and worsening courses of delirium and hypothesize that polypharmacy might be a prognostic factor for delirium.
Is There Any Relation Between Insulin Resistance and Menstrual Irregularity in Obese Women?
Authors: Almassinokiani Fariba , Akbari Peyman , Soheilipour Fahimeh 
Published: September 2020

Abstract
Objectives: Menstrual irregularity is a common issue in obese women that can cause anovulation and infertility. Insulin resistance is also common in obese women. We aimed to find the relation between menstrual pattern and insulin resistance in obese women.Results: The samples were 233 obese women 18-36 years old coming to obesity clinic for treatment of obesity. We checked Homeostatic Model Assessment for Insulin Resistance (HOMA – IR) and lipid profile in the clients and also we filled a form including the age, educational status, marital status, menstrual pattern and severity of hirsutism. Sample size was 233. The mean age of women was 25.6±8 years. The mean Body mass index (BMI) was 44.6±4.8 kg/m2. 84.55% of women had insulin resistance. There was significant relation between menstrual pattern and fasting insulin level (p=0.05). There was no significant relation between presence of Insulin resistance and menstrual pattern (p=0.28). There was significant relation between age and menstrual pattern (p=0.007). Based on the results, there was no significant relation between HOMA- IR and menstrual pattern (p=0.28). Perhaps type of obesity (android) may have relation with menstrual pattern and also we need to a standard IR definition to explain the relation between different findings.
Genome sequence analysis of the beneficial Bacillus subtilis PTA-271 isolated from a Vitis vinifera (cv. Chardonnay) rhizospheric soil: assets for sustainable biocontrol.
Authors: LEAL Catarina , Fontaine Florence , Aziz Aziz , Egas Conceiçao , Clement Christophe , Trotel-Aziz Patricia 
Published: September 2020

Abstract
Background: Bacillus subtilis strains have been widely studied for their innumerous benefits in agriculture, including viticulture. Providing numerous assets, B. subtilis spp. are described as promising plant-protectors against many pathogens and as influencers to adaptations in a changing environment. This study reports the draft genome sequence of the beneficial Bacillus subtilis PTA-271, isolated from the rhizospheric soil of healthy Vitis vinifera cv. Chardonnay at Champagne Region in France, attempting to draw outlines of its full biocontrol capacity. Results: The PTA-271 genome has a size of 4,001,755 bp, with 43.78% of G + C content and 3,945 protein coding genes. The draft genome of PTA-271 highlights (1) a functional swarming motility system hypothesizing a colonizing capacity and a strong interacting capacity, (2) strong survival capacities and (3) a set of genes encoding for bioactive substances. Bioactive compounds are known both to (i) stimulate plant growth or defenses such as hormones and elicitors, (ii) influence beneficial microbiota, and (ii) counteract pathogen aggressiveness such as effectors and many kinds of detoxifying enzymes. Conclusions: The plurality of the encoded biomolecules by Bacillus subtilis PTA-271 genome appears as strengths for PTA-271 biocontrol potential towards plants, offering a big potential against a broad spectrum of pathogens despite environmental constraints.