bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of the Prefrontal Cortex and Functional Connectivity during Maritime Operations: An fNIRS study
Authors: Fan Shiqi , Blanco‐Davis Eduardo , Zhang Jinfen , Bury Alan , Warren Jonathan , Yang Zaili , Yan Xinping , Wang Jin , Fairclough Stephen 
Published: November 2020

AbstractIntroductionWatchkeeping is a significant activity during maritime operations, and failures of sustained attention and decision‐making can increase the likelihood of a collision.MethodsA study was conducted in a ship bridge simulator where 40 participants (20 experienced/20 inexperienced) performed: (1) a 20‐min period of sustained attention to locate a target vessel and (2) a 10‐min period of decision‐making/action selection to perform an evasive maneuver. Half of the participants also performed an additional task of verbally reporting the position of their vessel. Activation of the prefrontal cortex (PFC) was captured via a 15‐channel functional near‐infrared spectroscopy (fNIRS) montage, and measures of functional connectivity were calculated frontal using graph‐theoretic measures.ResultsNeurovascular activation of right lateral area of the PFC decreased during sustained attention and increased during decision‐making. The graph‐theoretic analysis revealed that density declined during decision‐making in comparison with the previous period of sustained attention, while local clustering declined during sustained attention and increased when participants prepared their evasive maneuver. A regression analysis revealed an association between network measures and behavioral outcomes, with respect to spotting the target vessel and making an evasive maneuver.ConclusionsThe right lateral area of the PFC is sensitive to watchkeeping and decision‐making during operational performance. Graph‐theoretic measures allow us to quantify patterns of functional connectivity and were predictive of safety‐critical performance.
Communication‐related assessments in an Angelman syndrome mouse model
Authors: Perrino Peter A. , Chamberlain Stormy J. , Eigsti Inge‐Marie , Fitch Roslyn Holly 
Published: November 2020

AbstractIntroductionAngelman syndrome (AS) is a neurodevelopmental disorder characterized by motor deficits, seizures, some autistic‐like behaviors, and severe impairment of speech. A dysfunction of the maternally imprinted UBE3A gene, coupled with a functional yet silenced paternal copy, results in AS. Although studies of transgenic mouse models have revealed a great deal about neural populations and rescue timeframes for specific features of AS, these studies have largely failed to examine intermediate phenotypes that contribute to the profound communicative disabilities associated with AS.MethodsHere, we use a variety of tasks, including assessments of rapid auditory processing and social communication. Expressive vocalizations were directly assessed and correlated against other core behavioral measures (motor, social, acoustic perception) to model putative influences on communication.ResultsAS mice displayed the characteristic phenotypes associated with Angelman syndrome (i.e., social and motor deficits), as well as marginal enhancements in rapid auditory processing ability. Our characterization of adult ultrasonic vocalizations further showed that AS mice produce fewer vocalizations and vocalized for a shorter amount of time when compared to controls. Additionally, a strong correlation between motor indices and ultrasonic vocalization output was shown, suggesting that the motor impairments in AS may contribute heavily to communication impairments.ConclusionIn summary, the combination of motor deficits, social impairment, marginal rapid auditory enhancements, and altered ultrasonic vocalizations reported in a mouse model of AS clearly parallel the human symptoms of the disorder. This mouse model offers a novel route to interrogate the underlying genetic, physiologic, and behavioral influences on the under‐studied topic of impaired communication in AS.
Managing sustainability in luxury industry to pursue circular economy strategies
Authors: Shashi  , Centobelli Piera , Cerchione Roberto , Mittal Amit 
Published: November 2020

AbstractSustainable luxury research has received growing attention in the most recent years as it requires firms and supply chains to design circular business models and strategies to tackle environmental, financial, and social issues. However, previous research still falls short to deepen how luxury firms design and manage sustainable supply chain practices according to the circular principles. This paper adopts bibliometric and network analysis to evaluate a sample of 747 papers published over the last 35 years. The descriptive statistics and science mapping approaches utilizing cocitation analysis were performed with VOSviewer software to contribute to the ongoing development of sustainability in luxury research with the aim to develop a systemic framework for circular supply chain and offer a comprehensive overview on the topic. The main findings of this paper will help academicians and practitioners to improve the body of knowledge on the topic and provide an overview of promising future research avenues.
In‐situ IR Spectroscopy Study of Reactions of C3 Oxygenates on Heteroatom (Sn, Mo, and W) doped BEA Zeolites and the Effect of Co‐adsorbed Water
Authors: Najmi Sean , So Jungseob , Stavitski Eli , McDermott William P. , Lyu Yimeng , Burt Sam P. , Hermans Ive , Sholl David S. , Sievers Carsten 
Published: November 2020

AbstractThe reactions of acetone and hydroxyacetone over heteroatom doped BEA zeolites (Sn, Mo, and W) in the presence and absence of H2O vapor are investigated using infrared spectroscopy. Acetone is converted to mesityl oxide over Sn‐BEA exclusively. At higher temperatures, larger oxygenates such as phorones, aromatics, and coke form. The presence of co‐adsorbed water in Sn‐BEA suppresses tautomerization. H2O vapor is also beneficial for minimizing coke formation at high temperatures. Hydroxyacetone is converted into 2‐hydroxypropanal over Sn‐BEA, exhibiting high affinity to Sn sites up to 400 °C. Sn‐BEA catalyzes conversion of hydroxyacetone into the enol in the absence of H2O, but exposure to H2O induces the formation of 2‐hydroxypropanal and subsequent conversion to acrolein. The Lewis acid descriptors are used to rationalize the reaction pathways. For the isomerization of hydroxyacetone into 2‐hydroxypropanal, the hardness of acid sites influences the reaction and correlates with the overall Lewis acidity of the catalysts, respectively. However, the size of the exchanged metal significantly affects aldol condensation, where keto and enol forms of acetone adsorb to active sites simultaneously.
Steuerkopf für intelligente Kommunikation
Authors: Mulenga Rex 
Published: November 2020

AbstractDer universelle Ventil‐Steuerkopf Typ 8681 von Bürkert bietet mit der neuen IO‐Link‐Kommunikationsschnittstelle eine wirtschaftliche Datenübertragung für Industrie‐4.0‐Applikationen im Prozessbereich. Betriebs‐ und Diagnosedaten stehen nun in der Leiteben
Umstieg wagen, Kosten sparen
Authors: Landgraf Evelyn 
Published: November 2020

AbstractMittlerweile hat es sich herumgesprochen, dass sich moderne verfahrenstechnische Anlagen nur dann effizient betreiben lassen, wenn die Daten aus der Planungsphase auch für Betrieb, Instandhaltung und Modernisierung verfügbar sind. Eine papiergestützte Dok
Vorgelagert oder im Kanal
Authors: Groth Michael 
Published: November 2020

AbstractDer Doppelwellenzerkleinerer N.Mac ist für die Zerkleinerung zahlreicher Materialien konzipiert und eignet sich für die Abwasserbehandlung, Biogas‐ und Biomasseanlagen und für viele Abfall‐ und Industrieanwendungen. Der Zerkleinerer ist wahlweise mit eine
Cardiometabolic risk factors and survival after cancer in the Women's Health Initiative
Authors: Simon Michael S. , Hastert Theresa A. , Barac Ana , Banack Hailey R. , Caan Bette J. , Chlebowski Rowan T. , Foraker Randi , Hovsepyan Gayane , Liu Simin , Luo Juhua , Manson JoAnn E. , Neuhouser Marian L. , Okwuosa Tochukwu M. , Pan Kathy , Qi Lihong , Ruterbusch Julie J. , Shadyab Aladdin H. , Thomson Cynthia A. , Wactawski‐Wende Jean , Waheed Nida , Beebe‐Dimmer Jennifer L. 
Published: November 2020

BackgroundCardiometabolic abnormalities are a leading cause of death among women, including women with cancer.MethodsThis study examined the association between prediagnosis cardiovascular health and total and cause‐specific mortality among 12,076 postmenopausal women who developed local‐ or regional‐stage invasive cancer in the Women's Health Initiative (WHI). Cardiovascular risk factors included waist circumference, hypertension, high cholesterol, and type 2 diabetes. Obesity‐related cancers included breast cancer, colorectal cancer, endometrial cancer, kidney cancer, pancreatic cancer, ovarian cancer, stomach cancer, liver cancer, and non‐Hodgkin lymphoma. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) adjusted for important predictors of survival.ResultsAfter a median follow‐up of 10.0 years from the date of the cancer diagnosis, there were 3607 total deaths, with 1546 (43%) due to cancer. Most participants (62.9%) had 1 or 2 cardiometabolic risk factors, and 8.1% had 3 or 4. In adjusted models, women with 3 to 4 risk factors (vs none) had a higher risk of all‐cause mortality (HR, 1.99; 95% CI, 1.73‐2.30), death due to cardiovascular disease (CVD) (HR, 4.01; 95% CI, 2.88‐5.57), cancer‐specific mortality (HR, 1.37; 95% CI, 1.1‐1.72), and other‐cause mortality (HR, 2.14; 95% CI, 1.70‐2.69). A higher waist circumference was associated with greater all‐cause mortality (HR, 1.17; 95% CI, 1.06‐1.30) and cancer‐specific mortality (HR, 1.22; 95% CI, 1.04‐1.42).ConclusionsAmong postmenopausal women diagnosed with cancer in the WHI, cardiometabolic risk factors before the cancer diagnosis were associated with greater all‐cause, CVD, cancer‐specific, and other‐cause mortality. These results raise hypotheses regarding potential clinical intervention strategies targeting cardiometabolic abnormalities that require future prospective studies for confirmation.Lay Summary

This study uses information from the Women's Health Initiative (WHI) to find out whether cardiac risk factors are related to a greater risk of dying among older women with cancer. The WHI is the largest study of medical problems faced by older women in this country.

The results show that women who have 3 or 4 risk factors are more likely to die of any cause, heart disease, or cancer in comparison with women with no risk factors.

It is concluded that interventions to help to lower the burden of cardiac risk factors can have an important impact on survivorship among women with cancer.
First the seed: Genomic advances in seed science for improved crop productivity and food security
Authors: Dwivedi Sangam L. , Spillane Charles , Lopez Francesca , Ayele Belay T. , Ortiz Rodomiro 
Published: November 2020

AbstractSeeds are valuable sources of carbohydrates, lipids, proteins, fibers, minerals, and vitamins. They provide energy and nutrition to germinating seedlings, food to humans, feed to livestock, and feedstocks to industry. High‐throughput analyses of gene expression in crops has identified many candidate genes associated with seed dormancy, longevity, germination, and vigor. In this review, we cover the latest research focusing on such key seed traits. Transcriptome analyses of time courses of seed filling have identified sets of genes expressed at different stages of this process. The potential role of epigenetics (including seed–endosperm imprinted genes) in regulating seed development and chemistry is highlighted herein. We also discuss how advances in genomics and seed biology are facilitating the unravelling of associations between seed traits with gene bank accessions and gene sequences, including how functional research can accelerate the discovery of allelic variants. Such knowledge of functional effects relating to gene variants is necessary for more efficient and cost‐effective management of genetic resources or for redesigning crops with specific seed characteristics. For instance, gene bank curators may assess seed viability by monitoring changes in gene expression of biomarker genes in dry seed samples to decide germplasm regeneration and assess genetic integrity of collections by monitoring changes in diversity and allele frequencies between samples of same accession stored in gene banks. We highlight that resistance to preharvest sprouting can be enhanced through genomics‐assisted breeding in otherwise nondormant rice (Oryza sativa L.) and wheat (Triticum aestivum L.) cultivars, while pimt, another valuable marker for seed longevity, may be deployed to enhance seed vigor in crops.
Study on chaotic oscillator‐based algorithm for weak GLONASS signal acquisition
Authors: Liu Yu , Zou Xing , Niu Xiaowei , Hu Zhengquan 
Published: November 2020

SummaryAccording to the characteristics of the chaotic oscillator in detecting weak signals, an algorithm based on Duffing chaotic oscillator array was proposed for acquisition of weak GLONASS signals. By means of GLONASS intermediate frequency and Duffing chaotic oscillator models, Lyapunov exponent is adopted to judge the critical condition of phase track and decide whether GLONASS signals exist or not by the change of the critical condition, and numeric iteration procedure is used to calculate the exponent. Finally, the performance of algorithm is simulated using GLONASS intermediate frequency data. The results indicate that acquisition algorithm can satisfy the need of object positioning in low signal‐to‐noise ratio environment.
The association of Epstein‐Barr virus infection with CXCR3+ B‐cell development in multiple sclerosis: impact of immunotherapies
Authors: van Langelaar Jamie , Wierenga‐Wolf Annet F. , Samijn Johnny P.A. , Luijks Caroline J.M. , Siepman Theodora A. , van Doorn Pieter A. , Bell Andrew , van Zelm Menno C. , Smolders Joost , van Luijn Marvin M. 
Published: November 2020

AbstractEpstein–Barr virus (EBV) infection of B cells is associated with increased multiple sclerosis (MS) susceptibility. Recently, we found that CXCR3‐expressing B cells preferentially infiltrate the CNS of MS patients. In chronic virus‐infected mice, these types of B cells are sustained and show increased antiviral responsiveness. How EBV persistence in B cells influences their development remains unclear. First, we analyzed ex vivo B‐cell subsets from MS patients who received autologous bone marrow transplantation (n = 9), which is often accompanied by EBV reactivation. The frequencies of nonclass‐switched and class‐switched memory B cells were reduced at 3–7 months, while only class‐switched B cells returned back to baseline at 24–36 months posttransplantation. At these time points, EBV DNA load positively correlated to the frequency of CXCR3+, and not CXCR4+ or CXCR5+, class‐switched B cells. Second, for CXCR3+ memory B cells trapped within the blood of MS patients treated with natalizumab (anti‐VLA‐4 antibody n = 15), latent EBV infection corresponded to enhanced in vitro formation of anti‐EBNA1 IgG‐secreting plasma cells under GC‐like conditions. These findings imply that EBV persistence in B cells potentiates brain‐homing and antibody‐producing CXCR3+ subsets in MS.
Checkpoints controlling the induction of B cell mediated autoimmunity in human autoimmune diseases
Authors: Reijm S. , Kissel T. , Toes R.E.M. 
Published: November 2020

AbstractB cell targeting therapies are effective in various autoimmune diseases, among others rheumatoid arthritis, pemphigus vulgaris, and systemic lupus erythematosus. Given these successes, it is evident that B cells are central orchestrators in the processes leading to the signs and symptoms hallmarking many human autoimmune diseases. The pathways provoking the generation of such autoreactive B cells or mechanisms preventing their induction in health are, however, poorly explored. Nevertheless, such information is crucial for the development of preventative/curative interventions aiming to permanently deplete‐ or prohibit the emergence of autoreactive B cells. Hence, this review will focus on how B cell tolerance might be breached, and which checkpoints are at play preventing the arousal of autoreactive B cells in human. Especially antigen presentation by follicular dendritic cells, somatic hypermutation, and cross‐reactivity to the microbiome/environment could operate as actors playing pivotal roles in the induction of B cell‐mediated humoral autoimmunity. Moreover, we highlight the human autoimmune disease rheumatoid arthritis as a prototype where autoreactive B cells combine several mechanisms to overcome peripheral B cell checkpoints.
Nylon‐11 nanowires for triboelectric energy harvesting
Authors: Choi Yeon Sik , Kar‐Narayan Sohini 
Published: November 2020

AbstractTriboelectric energy harvesting from ambient mechanical sources relies on motion‐generated surface charge transfer between materials with different electron affinities. In order to achieve highly efficient energy harvesting performance, choosing materials with a high surface charge density is crucial, and odd‐numbered polyamides (Nylons), such as Nylon‐11, are particularly promising due to their strong electron‐donating characteristics and the possibility to achieve dipolar alignment leading to high surface potential. The use of Nylon‐11 as a material for triboelectric energy harvesting has been rather limited due to the extreme processing conditions required for film fabrication, and the high‐voltage poling process required for dipole alignment. However, several methods to achieve “self‐poled” Nylon‐11 nanowires via facile nanoconfinement techniques have been demonstrated recently, leading to highly efficient Nylon‐11 nanowire‐based triboelectric nanogenerators. Here, we review the most recent advances in the fabrication of Nylon‐11 nanowires, with a focus on how nanoconfinement‐based fabrication methods can be used to control phase and crystallinity. These growth methods lead to self‐poled nanowires without the requirement for subsequent electrical poling, facilitating their integration into triboelectric energy harvesting devices. Strategies to fabricate Nylon‐11 nanowires for applications in triboelectric devices can be extended to other polymeric families as well.image
Terephthalic acid‐directed supramolecular Cu(II)‐metallogel for photosensitive semiconducting Schottky diode with promising electronic charge transportation
Authors: Dhibar Subhendu , Dey Arka , Majumdar Santanu , Ray Partha Pratim , Dey Biswajit 
Published: November 2020

SummaryTerephthalic acid‐based supramolecular metallogel of Cu(II) (ie, Cu‐TA) is developed by sonicating the mixture of copper(II) acetate monohydrate and terephthalic acid in N,N‐dimethyl formamide solvent. The rheological study is performed to expose the mechanical property of metallogel. The flake‐like morphological patterns are found through FESEM microstructural investigations. The formation strategy, crystalline nature, and thermal behavior of the Cu‐TA metallogel are also studied. The optical and electrical properties of Cu‐TA metallogel are exhaustively scrutinized, and the measured data show that Cu‐TA metallogel is semiconducting in nature. The electrical analysis indicates that the conductivity of Cu‐TA metallogel increased up to ~four times under illumination (7.49 × 10−5 S m−1) rather than the nonirradiation condition (1.83 × 10−5 S m−1). The measured I‐V characteristics of Cu‐TA metallogel‐based thin‐film metal‐semiconductor (MS) junction devices under irradiation and nonirradiation conditions show a nonlinear rectifying behavior, typical of a Schottky diode (SD).
Characterization of odour‐active compounds of sour guava (Psidium acidum[DC.]Landrum) fruit by gas chromatography‐olfactometry and odour activity value
Authors: Pino Jorge A. , Trujillo Reinaldo 
Published: November 2020

AbstractVolatile compounds in sour guava (Psidium acidum [DC.] Landrum) were isolated by headspace‐solid‐phase microextraction (HS‐SPME) and solvent‐assisted flavour evaporation (SAFE). Analyses were performed by GC‐FID and GC‐MS. By GC‐O, the HS‐SPME extract was evaluated by frequency analysis, whereas the SAFE extract was assessed by aroma extract dilution analysis (AEDA) and odour activity value (OAV) to find the most odour‐active components. Twenty‐four volatiles were found as odour‐active compounds and contribute to the typical sour guava aroma, from which hexyl acetate, 3‐methylbutyl butanoate, (Z)‐3‐hexenyl acetate, (Z)‐3‐hexenyl hexanoate, nonanal and (E)‐β‐ionone presented the highest aroma contribution in sour guava fruit. Results demonstrated a good resemblance between the typical aroma of the fruit and the aroma model.
Induction of interleukin‐6 by irradiation and its role in epithelial mesenchymal transition and radioresistance of nasopharyngeal carcinoma cells
Authors: Yuan Xun , Zhang Linli , Huang Yu , Liu Dongbo , Peng Ping , Liu Shunfang , Long Guoxian , Hu Guangyuan , Sun Wei 
Published: November 2020

AbstractBackgroundEpithelial mesenchymal transition (EMT) participates in the radioresistance of cancer cells. In this study, we evaluated whether interleukin‐6 (IL‐6) regulates EMT and subsequent radioresistance in nasopharyngeal carcinoma (NPC) cells.MethodsWestern blot was used to analyze the expression of proteins. Immunofluorescent assay was performed to detect the position and content of specific proteins. Colony formation assay was applied to measure the proliferation ability of NPC cells. Flow cytometry was adopted to measure cell apoptosis.ResultsNPC cells seen with typical morphological transition and unique proteins change of EMT when exposed to irradiation. IL‐6 and its downstream signal molecules elevated in irradiated cells. Blocking IL‐6 with anti‐IL‐6 receptor antibody hampered EMT and radioresistance. Cell radiosensitivity and apoptosis rates in irradiated NPC cells declined significantly upon IL‐6 stimulation.ConclusionIrradiation could induce EMT and activate IL‐6 signaling in NPC cell lines. Blocking IL‐6 was able to inhibit EMT and cellular radioresistance.
Analysis of palliative care treatment among head and neck patients with cancer: National perspective
Authors: Sullivan Christopher Blake , Al‐Qurayshi Zaid , Chang Kristi , Pagedar Nitin A. 
Published: November 2020

AbstractBackgroundTo analyze the characteristics and survival patterns of patients with head and neck squamous cell carcinoma (SCC) who received palliative treatment during their first course of treatment.MethodsCohort analysis utilizing the National Cancer Data Base (NCDB) of patients with a diagnosis of oral cavity/oropharyngeal, hypopharyngeal, and laryngeal SCC. Statistical analysis included multivariate logistic regression and Cox Hazard ratio modeling, and Kaplan‐Meier survival analysis.Results165 081 patients were included, of which 2747 patients received palliative treatment. Patients who received palliative treatment tended to be ≥65 years old, black, Charlson/Deyo score ≥3, hypopharyngeal cancer, stage (III‐IV), with Medicaid insurance (P < .05). Patients were more likely to be treated with palliative intent if they underwent chemotherapy/radiotherapy and declined surgery (P < .001) compared to patients who underwent surgery and declined chemotherapy/radiotherapy (P = .006).ConclusionsPalliative care use in head and neck oncology is associated with older patients, non‐whites, Medicaid patients, and nonsurgically treated patients.