bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Keto–Enol Tautomerism of Biliverdin in Bacteriophytochrome: Could it Explain the Bathochromic Shift in the Pfr Form?†
Authors: Villegas‐Escobar Nery , Matute Ricardo A. 
Published: October 2020

AbstractPhytochromes are ubiquitous photoreceptors found in plants, eukaryotic algae, bacteria and fungi. Particularly, when bacteriophytochrome is irradiated with light, a Z‐to‐E (photo)isomerization takes place in the biliverdin chromophore as part of the Pr‐to‐Pfr conversion. This photoisomerization is concomitant with a bathochromic shift in the Q‐band. Based on experimental evidence, we studied a possible keto–enol tautomerization of BV, as an alternative reaction channel after its photoisomerization. In this contribution, the noncatalyzed and water‐assisted reaction pathways for the lactam–lactim interconversion through consecutive keto–enol tautomerization of a model BV species were studied deeply. It was found that in the absence of water molecules, the proton transfer reaction is unable to take place at normal conditions, due to large activation energies, and the endothermic formation of lactim derivatives prevents its occurrence. However, when a water molecule assists the process by catalyzing the proton transfer reaction, the activation free energy lowers considerably. The drastic lowering in the activation energy for the keto–enol tautomerism is due to the stabilization of the water moiety through hydrogen bonds along the reaction coordinate. The absorption spectra were computed for all tautomers. It was found that the UV–visible absorption bands are in reasonable agreement with the experimental data. Our results suggest that although the keto–enol equilibrium is likely favoring the lactam tautomer, the equilibrium could eventually be shifted in favor of the lactim, as it has been reported to occur in the dark reversion mechanism of bathy phytochromes.
Gaussian unitary ensembles with two jump discontinuities, PDEs, and the coupled Painlevé II and IV systems
Authors: Lyu Shulin , Chen Yang 
Published: October 2020

AbstractWe consider the Hankel determinant generated by the Gaussian weight with two jump discontinuities. Utilizing the results of Min and Chen [Math. Methods Appl Sci. 2019;42:301‐321] where a second‐order partial differential equation (PDE) was deduced for the log derivative of the Hankel determinant by using the ladder operators adapted to orthogonal polynomials, we derive the coupled Painlevé IV system which was established in Wu and Xu [arXiv: 2002.11240v2] by a study of the Riemann‐Hilbert problem for orthogonal polynomials. Under double scaling, we show that, as , the log derivative of the Hankel determinant in the scaled variables tends to the Hamiltonian of a coupled Painlevé II system and it satisfies a second‐order PDE. In addition, we obtain the asymptotics for the recurrence coefficients of orthogonal polynomials, which are connected with the solutions of the coupled Painlevé II system.
The causes of welfare state expansion in democratic middle‐income countries: A literature review
Authors: Dorlach Tim 
Published: October 2020

AbstractThis article reviews the literature on the causes of welfare state expansion in democratic middle‐income countries across the Global South since the 2000s. After discussing challenges to measuring welfare state change, the article reviews research in political science and sociology and discusses nine potential causes of recent welfare state expansion, namely (a) economic development, (b) fiscal capacity, (c) democracy, (d) partisan ideology, (e) labour unions, (f) social mobilization, (g) cultural homogeneity, (h) institutional architecture, as well as (i) welfare rights and norms. The review thus reveals that recent welfare state expansion in democratic middle‐income countries has been driven by a similar set of causes as post‐war welfare state expansion in the Global North. The pronounced expansion of non‐contributory social policies has, in some contrast, also been characterized by more bipartisan and transnational political dynamics. The article concludes by outlining avenues for future research and by calling for more scholarly attention to the consolidation and testing of existing theories.
Are You Threatening Me? Asian‐American Panethnicity in the Trump Era
Authors: Le Danvy , Arora Maneesh , Stout Christopher 
Published: October 2020

ObjectiveThis study explores the effect of Donald Trump's candidacy, and first year in office, on Asian‐American linked fate. We argue that the use of anti‐Asian and anti‐immigrant messaging during the 2016 election, and the enactment of discriminatory policies once elected, increased feelings of panethnic linked fate among Asian Americans.MethodTo test our hypotheses, we assess Asian Americans’ levels of linked fate before the 2016 election, immediately after the 2016 election, and one year after the 2016 election with several time‐series surveys.ResultsWe find that Asian‐American linked fate is higher after the election and remains high one year later. Qualitative data collected through open‐ended survey responses suggest that the increase in panethnic linked fate can be at least partially attributed to Trump's discriminatory rhetoric.ConclusionThe results have implications for Asian‐American political behavior, particularly mobilization, by invoking collective action through panethnic linked fate.
Transborder Film Production Between Mainland China and Hong Kong After CEPA: The Interplay Between Political Orientation and Market Forces
Authors: Zhang Xu , Wang June 
Published: October 2020

AbstractCo‐production of films entails a variety of transborder mobility and trans‐local production networks, which are further complicated by state intervention through co‐production treaties or arrangements. This paper unravels the process of Mainland China–Hong Kong film co‐production that has been explosive after the promulgation of ‘Closer Economic Partnership Arrangement’ (CEPA). Drawing on the information of all Mainland–Hong Kong co‐produced films between 1998 and 2017, we chart the collaborative networks of studios and creative staffs and examine the commercial and artistic performances of co‐produced films to illustrate the impact of regulatory reform on the evolution of cross‐border film co‐production. We argue that CEPA is among the series of national regulatory reforms to enable marketisation of the film industry and, further, to construct an imagined new identity of Chinese culture at the supranational scale. However, the cultural goals have been given way to the commercial interests of co‐production with the implementation of CEPA policies.
Sleep restriction alters physiological and emotional responses to emotion induction
Authors: Hairston Ilana S. , Cohen‐Zion Mairav 
Published: October 2020

New Findings
What is the central question of this study?The aim of the present study was to assess the effects of sleep restriction on self‐report and autonomic responses to neutral and sad film clips.
What is the main finding and its importance?Ratings of sadness and heart rate deceleration were greater while watching the sad clip, with no effect of sleep restriction, whereas heart rate variability and skin conductance were impacted by sleep restriction and, to a lesser extent, by film clips. The results suggest that autonomic function was adaptively altered by sleep restriction, in order to maintain a ‘normal’ response to emotional cues, despite mounting fatigue.
AbstractHabitual insufficient sleep has long‐term health consequences via its impact on autonomic nervous system (ANS) function and on regulation of emotion. To our knowledge, the effects of insufficient sleep on emotion‐induced ANS function have not been tested. The present study aimed to address this lacuna. Using an emotion induction procedure, the effects of sleep restriction on physiological responses to validated neutral and sad film clips were assessed in a two‐by‐two, pseudo‐randomized, cross‐over design. Thirty‐one participants, aged 20–33 years, were assessed after sleeping for either 5 h (sleep restricted, SR) or 8 h (well rested, WR) per night, for three consecutive nights. Physiological measures included heart rate, heart rate variability, skin conductance response (SCR) and participants’ ratings of affect and fatigue. There was no effect of sleep conditions on self‐reported negative affect, but watching the sad clip reduced self‐reported fatigue in the SR condition. There was greater heart rate deceleration while watching sad relative to neutral clips, independent of the sleep condition. Sleep restriction increased heart rate variability measures, with no effect of emotion induction. There was an interaction of emotion induction with sleep condition for SCR, with more SCRs to sad relative to neutral clips in the WR condition, and the opposite effect in the SR condition. Combined, the results suggest that the ANS response to an emotional cue was altered by sleep restriction. The results suggest an adaptive ANS response to mild, chronic sleep restriction, resulting in constant heart rate response and self‐reported experience across WR and SR conditions, despite mounting fatigue.
Electrophysiological characterisation of atrial volume receptors using ex vivo models of isolated rat cardiac atria
Authors: Campbell Thomas , Shenton Fiona Cameron , Lucking Eric , Pyner Susan , Jones James Francis Xavier 
Published: October 2020

New Findings
What is the central question of this study?What ex vivo preparation of the rat's cavoatrial junction is efficient for characterising atrial mechanoreceptors?
What is the main finding and its importance?Of four different ex vivo preparations, static pressure, flow, open and euthermic, the optimal preparation was the euthermic one and involved direct recording from the right cardiac vagal branch with a Langendorff style perfusion at 37°C. Type A receptors were most common, and appeared insensitive to stretch and sensitive to atrial contraction. Type B and intermediate receptors were not isolated at 20°C but were observed closer to 37°C. The findings may suggest that type A and B receptors utilise different molecular transduction mechanisms.
AbstractAtrial volume receptors are a family of afferent neurons whose mechanically sensitive endings terminate in the atria, particularly at the cavoatrial junctions. These mechanosensors form the afferent limb of an atrial volume receptor reflex that regulates plasma volume. The prevailing functional classification of atrial receptors arose as a result of in vivo recordings in the cat and dog and were classified as type A, B or intermediate according to the timing of peak discharge during the cardiac cycle. In contrast, there have been far fewer studies of the common small laboratory mammals such as the rat. Using several ex vivo rat cavoatrial preparations, a total of 30 successful single cavoatrial mechanosensory recordings were obtained. These experiments show that the rat possesses type A, B and intermediate atrial mechanoreceptors as described for larger mammals. Recording these cavoatrial receptors proved challenging from the main vagus, but direct recording from the cardiac vagal branch greatly increased the yield of mechanically sensitive single units. In contrast to type A units, type B atrial mechanoreceptor activity was never observed at room temperature but required elevation of temperature to a more physiological range in order to be detected. The adequate stimulus for these receptors remains unclear; however, type A atrial receptors appear insensitive to direct atrial stretch when applied using a programmable positioner. The findings may suggest that type A and type B atrial receptors utilise different molecular transduction mechanisms.
Testing Oxygen Nuclear Data Libraries in Research Center Rez
Authors: Schulc Martin , Košťál Michal , Novák Evžen , Šimon Jan , Leal Luiz 
Published: October 2020

Abstract
Oxygen belongs to the group of the most important isotopes in the nuclear data field. The aim of this paper is validate various oxygen nuclear data libraries in different scenarios with high content of oxygen. For this purpose, fast neutron spectra were measured by a stilbene scintillation detector in the region of 1–10 MeV in the three model cases involving 252Cf neutron source and light water reactor. The cases include measurements of leakage spectra using 252Cf neutron source placed in the centers of the light water and heavy water spheres of 0.30 m diameter. Following measurements were carried out inside the concrete biological shielding of the VVER-1000 mock-up simulator in the LR-0 reactor and in the dry channel located in the center of the special core placed in the LR-0 reactor. In the case of the special core, symmetric active core consisted of six standard fuel assemblies which surround the experimental dry module, where the fast neutron spectrum was measured. The measured neutron spectra were compared with MCNP6 transport code calculations in ENDF/B-VII.1, ENDF/B-VIII.0, JENDL-4.0, and IRSN 16O nuclear data evaluations. Experimental results for all cases follow similar trend. All considered libraries underestimate experimental measurement in the region of 3–4 MeV in all cases.
Association between temperature changes and uveitis onset in mainland China
Authors: Tan Handan , Pan Su , Zhong Zhenyu , Shi Jing , Liao Weiting , Su Guannan , Kijlstra Aize , Yang Peizeng 
Published: October 2020

BackgroundSome uveitis subtypes show seasonal patterns. Whether these patterns are caused by seasonally varying temperatures or by other climatic factors remains unknown. This ecological research aimed to quantify the association between climate variability and uveitis onset.MethodsWe combined data from the largest database of uveitis cases with surface climate data to construct panel data. We used choropleth maps to visually assess spatial uveitis variations.ResultsAmong 12 721 reports of uveitis originating from 31 provinces of mainland China from 2006 to 2017, we found that a 1°C increase in monthly temperature was associated with a rise in approximately 2 uveitis reports per 1000 individuals (95% CI 0.00059 to 0.0029). This association was present across all provinces, ranging in effect size from 0.0011 to 0.072 (95% CI 0.00037 to 0.10). A clear 0–3 months of cumulative lagging effect was noted across all types of uveitis, with the strongest effect for non-infectious uveitis (0.0067, 95% CI 0.0041 to 0.013). Stratified by age and sex, we found that men and people aged 20–50 years were more affected by temperature variations. Our model predicts that China might experience an increase in uveitis cases due to future global warming.ConclusionOur study is the largest-ever investigation of the association between uveitis and climate and, for the first time, provides evidence that rising temperature can affect large-scale uveitis onset. These results may help promote and implement policies to mitigate future temperature increases and the burden of disease caused by global warming.
Lower resource utilization for patients with healed diabetic foot ulcers during participation in a prevention program with foot temperature monitoring
Authors: Isaac Adam L , Swartz Timothy D , Miller Mark L , Short Daniel J , Wilson Eleanor A , Chaffo Jamie L , Watson Eric S , Hu Haihong , Petersen Brian J , Bloom Jonathan D , Neff Nicole J , Linders David R , Salgado Simon J , Locke Jessica L , Horberg Michael A 
Published: October 2020

IntroductionWe assessed the impact of a diabetic foot ulcer prevention program incorporating once-daily foot temperature monitoring on hospitalizations, emergency department and outpatient visits, and rates of diabetic foot ulcer recurrence and lower extremity amputations for patients with recently healed foot ulcers.Research design and methodsIn this retrospective analysis of real-world data, we enrolled 80 participants with a healed diabetic foot ulcer in a year-long foot ulcer recurrence prevention program. Four outpatient centers within a large integrated healthcare system in the USA contributed to enrollment. We evaluated diabetic foot-related outcomes and associated resource utilization for participants during three periods: the 2 years before the program, the year during the program, and after the program ended. We reported unadjusted resource utilization rates during the program and the periods before and after it. We then adjusted rates of outcomes in each phase using an interrupted time series approach, explicitly controlling for overall trends in resource utilization and recurrence during the three periods.ResultsOur unadjusted data showed high initial rates of resource utilization and recurrence before enrollment in the program, followed by lower rates during the program, and higher rates of resource utilization and similar rates of recurrence in the period following the end of the program. The adjusted data showed lower rates of hospitalizations (relative risk reduction (RRR)=0.52; number needed to treat (NNT)=3.4), lower extremity amputations (RRR=0.71; NNT=6.4), and outpatient visits (RRR=0.26; absolute risk reduction (ARR)=3.5) during the program. We also found lower rates of foot ulcer recurrence during the program in the adjusted data, particularly for wounds with infection or greater than superficial depth (RRR=0.91; NNT=4.4).ConclusionsWe observed lower rates of healthcare resource utilization for high-risk participants during enrollment in a diabetic foot prevention program incorporating once-daily foot temperature monitoring.Trial registration numberNCT04345016.
Normal alkaline phosphatase levels are dependent on race/ethnicity: National Health and Nutrition Examination Survey data
Authors: Gonzalez Humberto C , Imam Zaid , Wong Robert , Li Jia , Lu Mei , Trudeau Sheri , Gordon Stuart C , Imam Mohammad , Gish Robert G 
Published: October 2020

ObjectiveThe range of normal serum alkaline phosphatase is not well defined. We used data from the National Health and Nutrition Examination Survey from 2009 to 2016 to generate normal ranges for a racially diverse sample of healthy adults.MethodsRespondents 18 years or older were included. Conditions known to elevate alkaline phosphatase were cause for exclusion. Alkaline phosphatase was measured using a colorimetric method based on standardised National Health and Nutrition Examination Survey protocols. Because alkaline phosphatase values were not normally distributed, log transformation was used. We calculated upper limits of normal (97.5 percentile), stratified by sex and race/ethnicity, and 90% CIs for the upper limits of normal.Results1199 respondents (673 female, 526 male) had body mass index from 18.5 to less than 25. Upper limits of normal were highest among Hispanics (123.2 IU/L (90% CI 110.2 to 136.7) for females; 123.8 IU/L (90% CI 112.0 to 135.1) for males), followed by African Americans (109.9 IU/L (90% CI 97.3 to 122.4) for females; 116.3 IU/L (90% CI 105.0 to 126.1) for males) and whites (97.1 IU/L (90% CI 91.0 to 103.4) for females; 109.6 IU/L (90% CI 102.1 to 116.3) for males). Asian American/Pacific Islander respondents had the lowest results: 93.8 IU/L (90% CI 88.2 to 99.5) for females and 95.3 IU/L (90% CI 88.1 to 102.1) for males.ConclusionsThe upper limit of normal alkaline phosphatase varies by race/ethnicity in a large US sample with body mass index of 18.5<25.
Trends in sports-related emergency department visits in the Netherlands, 2009–2018
Authors: Olij Branko F , Kemler Ellen , Valkenberg Huib , Stam Christine , Gouttebarge Vincent , Verhagen Evert 
Published: October 2020

ObjectivesWe aim to describe time trends of severe sports-related emergency department (ED) visits in the Netherlands, from 2009 to 2018.MethodsData were extracted from the Dutch Injury Surveillance System by age, gender, sports activity and injury diagnosis, from 2009 to 2018. Absolute numbers and time trends of severe sports-related ED visits were calculated.ResultsBetween 2009 and 2018, the overall numbers of severe sports-related ED visits in the Netherlands have significantly decreased by 14% (95% CI −19% to −9%). This trend was seen among men (−12%; 95% CI −18% to −6%), women (−19%; 95% CI −26% to −11%) and individuals aged 18–34 years (−19%; 95% CI −28% to −10%). The number of ED visits has significantly decreased over time in soccer (−15%; 95% CI −24% to −6%), ice-skating (−80%; 95% CI −85% to −73%) and in inline/roller skating (−38%; 95% CI −55% to −15%). This was not the case in road cycle racing (+135%; 95% CI +85% to +198%) and mountain bike racing (+80%; 95% CI +32% to+146%). In terms of sports injury diagnoses, the number of fractured wrists (−15%; 95% CI −24% to −5%), fractured hands (−37%; 95% CI −49% to −21%), knee distortions (−66%; 95% CI −74% to −55%), and fractured lower legs (−38%; 95% CI −55% to −14%) significantly decreased over time.ConclusionOur study shows a promising reduction in the number of severe sports-related ED visits across most age groups and sports activities. As the number of ED visits increased in road cycle and mountain bike racing, it is important to find out what caused these increases. Furthermore, it is essential to determine trends in exposure hours and to evaluate and implement injury prevention programmes specific for these sports activities.
Pre-emptive epidural analgesia for acute and chronic post-thoracotomy pain in adults: a systematic review and meta-analysis
Authors: Park Sun-Kyung , Yoon Susie , Kim Bo Rim , Choe Suk Hyung , Bahk Jae-Hyon , Seo Jeong-Hwa 
Published: October 2020

Background and objectives
Epidural analgesia is the gold standard for post-thoracotomy pain management and can be started before or after surgical incision. This systematic review and meta-analysis investigated whether pre-emptive epidural analgesia before thoracotomy incision reduces acute and chronic post-thoracotomy pain in adults compared with epidural analgesia after incision.

Methods
We searched databases including MEDLINE, Embase, and CENTRAL for randomized controlled trials comparing epidural analgesia initiated before (pre-emptive group) and after (control group) thoracotomy incision in adults. The primary outcomes were the pain intensity during rest and coughing within 72 hours after surgery and the incidence of pain 1 to 6 months after surgery. Data were combined with random-effects meta-analyses. We rated the quality of evidence as high, moderate, low, and very low using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) method.

Results
We included 19 trials with 1062 participants involving 529 in the pre-emptive group and 533 in the control group. The pain intensity was significantly lower at rest within 72 hours after surgery (19 studies, n=1062) and during coughing within 48 hours after surgery (11 studies, n=638), and the incidence of pain was significantly lower 1 to 6 months after surgery (6 studies, n=276) in the pre-emptive group than in the control group. The quality of evidence was moderate or low in the primary outcomes.

Conclusions
Our review provides low-quality evidence that pre-emptive epidural analgesia reduces the intensity of acute pain and the incidence of chronic pain after thoracotomy in adults.

Protocol registration number
CRD42019131620.