bluuebunny/crossref_metadata_2025_split huggingface dataset:
Klinische Entscheidungsfindung bei der Behandlung des diabetischen Makulaödems mit DEX-Implantat: ein Konsenspapier
Authors: Augustin Albert J. , Feltgen Nicolas , Haritoglou Christos , Hoerauf Hans , Maier Mathias M. , Mardin Christian Yahya , Schargus Marc 
Published: November 2019

Zusammenfassung
Hintergrund In Deutschland sind 2 intravitreal anzuwendende Kortikosteroide (Dexamethason und Fluocinolon) für die Behandlung des diabetischen Makulaödems (DMÖ) zugelassen. Der Einsatz von DEX-Implantat bei DMÖ ist in der täglichen Praxis bisher nicht im Detail definiert. Mithilfe eines Delphi-Panels und einer Runde von Retinaspezialisten sollte ein Konsens für die Anwendung von DEX-Implantat erarbeitet werden.
Material und Methoden Aus der Literatur wurden internationale und nationale Behandlungsempfehlungen identifiziert. Eine Steuerungsgruppe erarbeitete einen Katalog von 72 Aussagen zur Ätiologie und Pathogenese des DMÖ, Therapie mit dem DEX-Implantat, Einsatz bei mit VEGF-Hemmern vorbehandelten Patienten, Verwendung von DEX-Implantat in der Kombination mit anderen Therapien, Sicherheit von DMÖ-Therapien sowie Therapiebelastung des Patienten. 22 niedergelassene Ophthalmologen und 6 Ophthalmologen aus der Klinik gaben über Survey Monkey ihre Bewertung zu den Aussagen ab. Die Definition des Konsenses zu einer Aussage galt als erfüllt, wenn mehr als 75% der Befragten einer Aussage zustimmten bzw. nicht zustimmten. Über nicht konsensfähige Aussagen wurde nach erneuter Diskussion in der Konsensrunde nochmals abgestimmt. In der Folge sollte auch ein Behandlungsschema für DMÖ mit fovealer Beteiligung vorgeschlagen werden.
Ergebnisse Sofern ein Patient unter VEGF-Hemmern unzureichend anspricht (Visusgewinn < 5 ETDRS-Buchstaben oder Reduktion der zentralen Netzhautdicke ≤ 20%), sollte nach 3 – 6 Monaten auf das DEX-Implantat umgestellt werden. DEX-Implantat ist ebenfalls geeignet für Augen mit länger bestehendem DMÖ, bei denen z. B. massive Lipidexsudate vorhanden sind. DEX-Implantat eignet sich als Ersttherapie insbesondere bei Pseudophaken, Patienten, die nicht willens oder in der Lage sind, enge Injektionsintervalle unter Anti-VEGF-Therapie einzuhalten oder für Patienten mit vaskulären Vorerkrankungen. Bei festgelegten Kontrollintervallen von 4 – 8 Wochen kann die Anwendung des DEX-Implantats flexibel und individuell erfolgen. Als Entscheidungsparameter gelten hierbei neben Visus und Netzhautdicke auch der Augeninnendruck. Eine Behandlung von beiden Augen am selben Tag sollte nicht stattfinden.
Schlussfolgerungen Der hier vorgestellte Algorithmus entspricht den Ergebnissen des Delphi-Prozesses und weicht u. U. von den Empfehlungen der Fachgesellschaft ab. Die im Rahmen der Befragung und Expertenrunde erarbeiteten Konsensempfehlungen für die Therapie von DMÖ können für den Einsatz des DEX-Implantats in der täglichen Praxis dienen.
Welchen Effekt haben Diabetestechnologien zur Behandlung von Hypoglykämieproblemen bei Typ-1-Diabetes?
Authors: Hermanns Norbert , Kulzer Bernhard , Ehrmann Dominic 
Published: November 2019

ZUSAMMENFASSUNGHypoglykämieprobleme sind eine bleibende Herausforderung für die Diabetestherapie. In den letzten Jahren wurden neue Diabetestechnologien wie die kontinuierliche Glukosemessung, das sensorbasierte Flash-Glukose-Monitoring, die sensorunterstützte Insulinpumpentherapie und Closed-Loop-Systeme entwickelt und evaluiert. In dieser Übersichtsarbeit soll der Beitrag dieser Diabetestechnologie für die Behandlung von Vermeidung von biochemischen und schweren Hypoglykämien aufgezeigt werden. Eine Metaanalyse zeigte, dass der Anteil biochemischer Hypoglykämien signifikant um 3–4 Prozentpunkte gesenkt werden konnte. Eine Metaanalyse mit Studien, welche speziell Probanden mit Hypoglykämien einschlossen, konnte die Inzidenz schwerer Hypoglykämien, deren Behandlung Fremdhilfe erforderte, durch kontinuierliche Glukosemessung und sensorunterstützte Insulinpumpentherapie ebenfalls signifikant um 53 % gesenkt werden. Moderne Diabetestechnologien sind neben edukativen Maßnahmen bei Typ-1-Diabetes eine wirksame Intervention bei Hypoglykämieproblemen.
Effects of Different Disinfection Methods on Microleakage of Giomer Restorations
Authors: Mutluay Abidin Talha , Mutluay Merve 
Published: November 2019

Abstract
Objectives The purpose of this in vitro study was to investigate the effects of different disinfection methods on microleakage of Class V Giomer restorations.
Materials and Methods Class V cavity preparation was performed on 40 sound permanent central incisors. Class V cavities (3 x 2 x 2 mm) were prepared on the buccal surfaces of the selected teeth. The teeth were randomly divided into four groups, each to be disinfected with a different method: Group 1—Disinfection with 2% chlorhexidine, Group 2—Disinfection with 6% sodium hypochlorite, Group 3—Disinfection with erbium, chromium: yttrium-scandium-gallium-garnet laser, Group 4—Control (distilled water). BeautiBond adhesive and Beautifil II Giomer restoration materials were applied to all surfaces of the cavities after the disinfection of all groups. The teeth were thermocycled 5,000 times (5–55°C), and then were immersed in 0.5% methylene blue for 24 hours. After rinsing, the teeth were longitudinally sectioned and dye penetration was assessed under a stereomicroscope (40x) to evaluate microleakage.
Statistical Analysis The results were statistically evaluated by using the Kruskal–Wallis and Mann–Whitney U tests.
Results Statistically, no significant difference was found between all four groups (p > 0.05). There was no statistically significant difference in microleakage scores of study groups (p > 0.05). Also, the microleakage scores of the gingival margins were significantly higher than the incisal margins (p < 0.0001).
Conclusions Application of the different cavity disinfectants has no effect on the microleakage of Class V Giomer restorations.
Evaluating the Impact of Interruptive Alerts within a Health System: Use, Response Time, and Cumulative Time Burden
Authors: Elias Pierre , Peterson Eric , Wachter Bob , Ward Cary , Poon Eric , Navar Ann Marie 
Published: November 2019

Abstract
Background Health systems often employ interruptive alerts through the electronic health record to improve patient care. However, concerns of “alert fatigue” have been raised, highlighting the importance of understanding the time burden and impact of these alerts on providers.
Objectives Our main objective was to determine the total time providers spent on interruptive alerts in both inpatient and outpatient settings. Our secondary objectives were to analyze dwell time for individual alerts and examine both provider and alert-related factors associated with dwell time variance.
Methods We retrospectively evaluated use and response to the 75 most common interruptive (“popup”) alerts between June 1st, 2015 and November 1st, 2016 in a large academic health care system. Alert “dwell time” was calculated as the time between the alert appearing on a provider's screen until it was closed. The total number of alerts and dwell times per provider per month was calculated for inpatient and outpatient alerts and compared across alert type.
Results The median number of alerts seen by a provider was 12 per month (IQR 4–34). Overall, 67% of inpatient and 39% of outpatient alerts were closed in under 3 seconds. Alerts related to patient safety and those requiring more than a single click to proceed had significantly longer median dwell times of 5.2 and 6.7 seconds, respectively. The median total monthly time spent by providers viewing alerts was 49 seconds on inpatient alerts and 28 seconds on outpatient alerts.
Conclusion Most alerts were closed in under 3 seconds and a provider's total time spent on alerts was less than 1 min/mo. Alert fatigue may lie in their interruptive and noncritical nature rather than time burden. Monitoring alert interaction time can function as a valuable metric to assess the impact of alerts on workflow and potentially identify routinely ignored alerts.
Florid Cemento-Osseous Dysplasia Masquerading as Osteomyelitis: An Exceptional Case Report in an Indian Female
Authors: Kaur Harveen , Patil Deepa Jatti 
Published: November 2019

AbstractFlorid cemento-osseous dysplasia consists of a group of fibro-osseous lesions with multiquadrant involvement, generally seen in the tooth-bearing portions of the mandible. These lesions are most common in middle-aged black women and rare in the Indian population, with only five cases been documented in the international literature in the Indian population. This manuscript presents a case of a 60-year-old female patient, who presented with a history of nonhealing extraction socket for 2 years and on examination demonstrated ulcerated alveolar mucosa with exposed necrotic bone. Panoramic and computed tomography images revealed multiple homogenous radio-opacities throughout the jaws. The lesion was diagnosed as florid cemento-osseous dysplasia on the basis of clinical and radiologic examination. The patient was prescribed antibiotics with iodoform dressings and proper oral hygiene maintenance.
Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane
Authors: Avan Paul , Le Gal Sébastien , Michel Vincent , Dupont Typhaine , Hardelin Jean-Pierre , Petit Christine , Verpy Elisabeth 
Published: November 2019

Significance
Patients lacking either otogelin or otogelin-like have congenital mild-to-moderate hearing impairment similar to that in patients lacking stereocilin. Stereocilin is associated with 2 types of links specific to the mechanosensitive antenna (stereocilia bundle) of cochlear outer hair cells: The horizontal top connectors joining stereocilia to one another and the attachment crowns coupling the tallest stereocilia to the tectorial membrane, an acellular structure overlying the sensory epithelium of the cochlea. By studying mutant mice lacking otogelin or otogelin-like and analyzing the distribution of these proteins, we show that they interact, directly or indirectly, with stereocilin to form the horizontal top connectors and tectorial membrane-attachment crowns, 2 structures likely satisfying similar mechanical requirements for cooperative stereociliary motion indispensable for optimal cochlear performance.
Perfectionism and attitudes towards doping in athletes: A continuously cumulating meta‐analysis and test of the 2 × 2 model
Authors: Madigan Daniel J. , Mallinson‐Howard Sarah H. , Grugan Michael C. , Hill Andrew P. 
Published: November 2019

AbstractPerfectionism may promote engagement in illegal and unacceptable behaviours such as doping. To examine this idea, in the present study, we had two aims. First, we re‐examined the relationship between perfectionism and attitudes towards doping and, in doing so, conducted a continuously cumulating meta‐analysis. Second, we extended our understanding of this relationship by providing the first test of the 2 × 2 model of perfectionism in context of doping. A sample of 181 university athletes (mean age 18.5 years) completed measures of perfectionism (evaluative concerns perfectionism [ECP] and personal standards perfectionism [PSP]) and attitudes toward doping. A continuously cumulating meta‐analysis based on five studies (including the present study; N = 952) indicated that ECP showed a significant small‐to‐medium positive relationship with attitudes towards doping (r + = .21), whereas PSP showed a nonsignificant small positive relationship with attitudes towards doping (r + = .07). In addition, moderated regression analysis provided support for two hypotheses of the 2 × 2 model. Specifically, pure ECP (high ECP, low PSP) was associated with more favourable attitudes towards doping than mixed perfectionism (high ECP, high PSP) and non‐perfectionism (low ECP, low PSP). The present findings suggest that ECP is a significant positive predictor of attitudes towards doping and that athletes who exhibit a combination of high ECP and low PSP are the most likely to be at risk of doping. Consequently, a focus on reducing ECP may be a valuable addition to anti‐doping education programmes.
A comparison study of electronical and photoelectrical properties of electron gases at (1 0 0), (1 1 0) and (1 1 1) LaAlO3/SrTiO3 interfaces
Authors: Liu G Z , Chen J Q , Jiang Y C , Zhao R , Qiu J , Gao J 
Published: November 2019

Abstract
(1 0 0), (1 1 0) and (1 1 1) LaAlO3/SrTiO3 (LAO/STO) interfaces show similar high mobility conduction. Here, we compare electronic transport and photoconductivity properties of electron gases at the three interfaces, considering their different polar continuity at the interface and the crystallographic symmetry. Epitaxial LAO films were grown on STO (1 0 0), (1 1 0) and (1 1 1) substrates by laser molecular beam epitaxy. All the electron gases at the interfaces exhibit metallic behaviors with close sheet carrier density (1013–1014 cm−2), the electron gas at (1 0 0) interface presents the highest mobility, which is almost one order of magnitude higher than that at (1 1 1) interface below 70 K. At lower temperatures, all the electron gases show obvious photoelectrical response to visible light illumination. Light-assisted Hall measurements indicate distinctly different mechanisms for the photoconductivity of electron gases at the three interfaces. Our results can assist the understanding of the high mobility of electron gases at oxide interfaces, which will be helpful to optimize the electronic properties for device applications.
An algorithm of adaptive stimulation of ecological and socio-economic development of a cross-border region
Authors: Kirhmeer L 
Published: November 2019

Abstract
Ecological, social, and economic development of a cross-border region is determined by regulated and unregulated factors, some of which are formed outside the region and even countries. Environmental pollution cannot be limited to territorial boundaries, and this requires taking into account this fact when developing programs and activities aimed at the regional ecological and socio-economic development.
Optimization of processing branches, needles, and leaves (“woody greens”) of dark-coniferous breeds of thin tree stands using a modified plant
Authors: Petrenko E , Parshikova V , Zaychenko E 
Published: November 2019

Abstract
The waste-free technological scheme is proposed in the paper. It is based on an installation which allows to optimize the integrated processing of woody greens (branches, needles, and leaves) from fir and spruce. This scheme takes into account their contribution to the mixtures made, as well as the age of plantations used to produce an essential oil and pine extract. An installation is designed with an internal and external condensation circuit of the vapor stream serving as the basis, the use of which increases yields and significantly reduces the time needed to release the water-soluble products being processed into coniferous extract.
On the issue of ensuring environmental safety of anthropogenic systems in cross-border areas of the Novosibirsk Region
Authors: Malgin E , Shemetova E , Bochkarev I 
Published: November 2019

Abstract
This article explores the concept of a cross-border region and analyzes sources contributing to environmental pollution. More than that, the authors focus on the features of monitoring and ensuring environmental safety of the cross-border region of Novosibirsk (Russian Federation) and Pavlodar Regions (Republic of Kazakhstan). As a result, measures and algorithms to optimize their sustainable development are suggested.
A granulometric composition of the Zauralye black soils
Authors: Plotnikov A , Sozinov A 
Published: November 2019

Abstract
The article presents results of the study devoted to the granulometric composition of Zauralye black soils. The main patterns of the profile differentiation of soils in connection with the genesis and anthropogenic load on agricultural land are considered. There are signs of elution in the upper part of the soil profile when analyzing the nature of the distribution of fractions of granulometric composition. In general, a black soil profile on the granulometric composition is poorly differentiated.
Formation of geoinformation-cartographic support of the Altai interregion on the example of creating the international atlas “Greater Altai: Nature, History, Culture”
Authors: Rotanova I N , Efremov G A , Peremitina S V 
Published: November 2019

Abstract
The article discusses the conceptual provisions used in creating the international cartographic project “Atlas of the Greater Altai: nature, history, culture” in the context of the formation of an international geo-information and cartographic support. The creation of the atlas of the Greater Altai is based on a number of methodological, conceptual, and organizational provisions, among which, first of all, the research search for new methods and approaches, the development of modern technologies for processing spatial data, cartographic modeling and cartographic research methods. Within the framework of this project, implementation of international cooperation, exchange of experience and achievements in the field of mapping, geoinformatics and GIS design is no less significant than the international cooperation, exchange of experience and achievements in the field of mapping, geoinformatics and GIS design.
Heavy metals in soil and plants (Agropyron pectiniforme Roem. Et Schult.) of the Pavlodar region (Kazakhstan)
Authors: Kanibolotskaya Yu , Listkov W , Shmidt N 
Published: November 2019

Abstract
The paper presents the key results of a study on the content of heavy metals (Ti, Mn, Cr, Fe, Ni, Cu, Zn, Pb, Sr) in soil and plant (Agropyron pectiniforme Roem. et Schult.) samples, which are taken in the zone of influence of enterprises of the northern and eastern industrial zones of Pavlodar (Kazakhstan) as part of a study of the state of vegetation in the same territory.
Features of microclonal reproduction of species of the genus Aristolochia L. in various nutrient environments
Authors: Demidenko E , Berseneva S 
Published: November 2019

Abstract
The paper presents a comparative analysis of the development of microshoots in primary explants of the species belonging to the genus Aristolochia, using various nutrient media. This allows selecting the most optimal methods for mass production of the sterile regenerated plant cultures in a shorter time for further introduction, reintroduction, and creation of industrial plantations.
Reconstruction of grain yield in the steppe zone of the Altai territory (south of Western Siberia) in the XIX-XX centuries on the basis of tree-ring chronologies of tape burs
Authors: Rygalova N V , Rygalov E V , Bykov N I 
Published: November 2019

Abstract
The article presents the results of the reconstruction of the yield of grain crops of the economy of the Volchikhinsky district of the Altai Territory (south of Western Siberia) on the basis of an extended tree-ring chronology until 1822. Based on the restored series, the cyclical nature of cereal productivity was analyzed. In particular, the 22-, 25-, and 27-year cycles are highlighted as the most significant. The increase in the amplitude of variability of the yield series was noted by year from the middle of the 19th century to the end of the 20th century.
A cost-effective evaluation of carrot resistance to Alternaria sp. and Fusarium sp.
Authors: Sokolova L M , Shatilov M V , Razin O A 
Published: November 2019

Abstract
Creation of forms, varieties, and hybrids of plants resistant to biotic factors is an important national economic task. It is known that the defeat of agricultural plants by fungal, bacterial, and viral diseases, as well as pests leads to a loss of 38.8% to 60.4% of the crop. The most promising way to protect plants from phytopathogens is selection, which allows to obtain varieties and hybrids of crops with complex resistance. However, the process of creating varieties and hybrids remains long and reaches ten years or more. At the same time, the degree of plant resistance to harmful organisms is often insufficient and does not always meet the requirements of production. The efficiency of the breeding process can be improved and accelerated through the use of rapid methods based on the selection in the laboratory of samples resistant to selective factor. The study was carried out in the Laboratory of Immunity at the VNIIO – Branch of the Federal State Budgetary FNCO in the Moscow region (Russia). As source material used, three samples of carrot breeding in VNIIO characterized by different resistance to Fusarium and Alternaria. The results of the experimental work showed the possibility of rapid assessment of carrots for resistance to PP fungal diseases. Alternaria and Fusarium seeds on the culture liquid filtrate at a concentration of 50% when germinating. This allows in the laboratory in a short time to evaluate a large number of breeding samples. The method of rapid assessment allows in 3.4 times to reduce the time required for the evaluation of breeding material and to reduce the consumption of seed.
An investigation of the process of producing the snow carbon dioxide
Authors: Neverov E N , Korotkiy I A , Korotkaya E V 
Published: November 2019

Abstract
Currently, the Russian and foreign scientists are actively involved in the development of technologies for the processing and utilization of carbon dioxide. At the Kemerovo State University, the technologies for processing and application of carbon dioxide in the food industry have been developed. One of them is based on throttling the CO2 coater in the generator. In order to determine the optimal operating modes of the generator, throttling is performed through washers with different throttle holes and their configuration. Also, throttling is performed with different angles of cones of snow formers at different temperatures of liquid carbon dioxide, which allows to reveal the influence of the above factors on the process of carbon dioxide snow formation. Based on the analysis of the obtained dependencies, we can conclude that the largest volume of snow weighing 0.25 kg was obtained using a cone with an angle of 12° and a temperature of minus 10°C. In percentage terms, 31.25% of the CO2 consumed liquid phase was reworked into snow. The additional lowering of the temperature of the liquid carbon dioxide, as well as the choice of the optimum, for a given temperature, the angle of the bell, have a significant impact on the volume of the snow carbon dioxide produced. However, in the process of choosing the temperature control parameters, possible additional economic costs of creating conditions for lowering the temperature of liquid carbon dioxide should be considered.
Economic assessment of the development potential of mushroom production in the Russian Federation
Authors: Devochkina N , Nurmetov R , Razin A 
Published: November 2019

Abstract
The article assesses the issue of further development of the industrial mushroom production in the Russian Federation in order to fulfill the objectives of the State Program for the Development of Agriculture and Regulation of Agricultural Products, Raw Materials, and Food Markets for 2013-2020. It was developed in accordance with the principles of ensuring food independence of Russia, sustainable development of rural territories of the Russian Federation, and financial sustainability of agricultural producers. Conducting an analysis of the state of the world mushroom industry, general trends in the organization of industrial enterprises, and the choice of modern technological solutions, which are the basis for the intensification of production and its economic efficiency. The article assesses a level of self-sufficiency of the Russian Federation in mushroom products on the basis of a comparison of the consumption levels of cultivated mushrooms in the developed European countries, the USA, as well as East and Southeast Asia.