bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supplementation of kaempferol toin vitromaturation medium regulates oxidative stress and enhances subsequent embryonic developmentin vitro
Authors: Zhao Yuhan , Xu Yongnan , Li Yinghua , Jin Qingguo , Sun Jingyu , E Zhiqiang , Gao Qingshan 
Published: October 2019

SummaryKaempferol (KAE) is one of the most common dietary flavonols possessing biological activities such as anticancer, anti-inflammatory and antioxidant effects. Although previous studies have reported the biological activity of KAE on a variety of cells, it is not clear whether KAE plays a similar role in oocyte and embryoin vitroculture systems. This study investigated the effect of KAE addition toin vitromaturation on the antioxidant capacity of embryos in porcine oocytes after parthenogenetic activation. The effects of kaempferol on oocyte quality in porcine oocytes were studied based on the expression of related genes, reactive oxygen species, glutathione and mitochondrial membrane potential as criteria. The rate of blastocyst formation was significantly higher in oocytes treated with 0.1 µm KAE than in control oocytes. The mRNA level of the apoptosis-related geneCaspase-3was significantly lower in the blastocysts derived from KAE-treated oocytes than in the control group and the mRNA expression of the embryo development-related genesCOX2andSOX2was significantly increased in the KAE-treated group compared with that in the control group. Furthermore, the level of intracellular reactive oxygen species was significantly decreased and that of glutathione was significantly increased after KAE treatment. Mitochondrial membrane potential (ΔΨm) was increased and the activity of Caspase-3 was significantly decreased in the KAE-treated group compared with that in the control group. Taken together, these results suggested that KAE is beneficial for the improvement of embryo development by inhibiting oxidative stress in porcine oocytes.
PARABOLIC COMPACTIFICATION OF HOMOGENEOUS SPACES
Authors: Čap Andreas , Gover A. Rod , Hammerl Matthias 
Published: October 2019

AbstractIn this article, we study compactifications of homogeneous spaces coming from equivariant, open embeddings into a generalized flag manifold$G/P$. The key to this approach is that in each case$G/P$is the homogeneous model for a parabolic geometry; the theory of such geometries provides a large supply of geometric tools and invariant differential operators that can be used for this study. A classical theorem of Wolf shows that any involutive automorphism of a semisimple Lie group$G$with fixed point group$H$gives rise to a large family of such compactifications of homogeneous spaces of$H$. Most examples of (classical) Riemannian symmetric spaces as well as many non-symmetric examples arise in this way. A specific feature of the approach is that any compactification of that type comes with the notion of ‘curved analog’ to which the tools we develop also apply. The model example of this is a general Poincaré–Einstein manifold forming the curved analog of the conformal compactification of hyperbolic space. In the first part of the article, we derive general tools for the analysis of such compactifications. In the second part, we analyze two families of examples in detail, which in particular contain compactifications of the symmetric spaces$\mathit{SL}(n,\mathbb{R})/\mathit{SO}(p,n-p)$and$\mathit{SO}(n,\mathbb{C})/\mathit{SO}(n)$. We describe the decomposition of the compactification into orbits, show how orbit closures can be described as the zero sets of smooth solutions to certain invariant differential operators and prove a local slice theorem around each orbit in these examples.
Faint Dwarf galaxies in nearby WINGS clusters: photometric characterization
Authors: Bettoni Daniela , Omizzolo Alessandro 
Published: October 2019

AbstractIn the cores of galaxy clusters there is a population of lows-mass stellar systems such as dwarf Early-type galaxies, ultra-compact dwarf galaxies (UCDs) and ultra diffuse dwarf galaxies. We present here the photometric and morphological characterization of this population of objects using deep CFHT images of a sample of clusters belonging to the WINGS survey (0.04 < z < 0.06). We study only galaxies that are spectroscopically confirmed members of the cluster. The population of dwarfs ranges from ∽ 30% for the more rich clusters to ∽ 5-6% for the less rich ones.
The Nature of the Triangulum-Andromeda Stellar Structures
Authors: Silva J. V. Sales , Perottoni H. , Cunha K. , Rocha-Pinto H. J. , Souto D. , Almeida-Fernandes F. 
Published: October 2019

AbstractThe outer stellar halo is home to a number of substructures that are remnants of former interactions of the Galaxy with its dwarf satellites. Triangulum-Andromeda (TriAnd) is one of these halo substructures, found as a debris cloud by Rocha-Pinto et al., (2004) using 2MASS M giants. Would be these structures related to dwarf galaxies or to the galactic disk? To uncover the nature of these stars we performed a high-resolution spectroscopic study (R = 40,000) along with a kinematic analysis using Gaia data. We determined the atmospheric parameters and chemical abundances of Ca and Mg for the 13 TriAnd candidate stars along with their respective orbits. Our results indicate that the TriAnd stars analyzed have a galactic nature but that these stars are not from the local thin disk.
HST STIS Observations of the Central Radio/X-Ray Source in the Compact Starburst Galaxy Henize 2-10
Authors: Rohr Eric , Whittle Mark , Reines Amy , Johnson Kelsey 
Published: October 2019

AbstractBased on radio and X-ray observations, it has been suggested that a black hole of mass ∼106 Mʘ resides in the dwarf starburst galaxy Henize 2-10. This unusual finding has important implications for the formation of massive black holes in the early universe since Henize 2-10 can be viewed as a low redshift analog to the first high-z galaxies. We present long-slit HST STIS spectra that include the central radio/X-ray source. While recent VLT-MUSE spectroscopic observations with 0″.7 seeing show no change in ionization near the central source, our higher spatial resolution STIS observations identify a distinct compact region at the location of the radio/X-ray source. Initial analysis reveals broader (FWHM ∼ 380 km s-1) blue-shifted lines of low ionization. Our analysis focuses on testing two scenarios: a LINER-like AGN and a young (few decades) SNR.
Subaru Hyper Suprime-Cam Survey for the Local Group Dwarf Galaxies: Ursa Minor
Authors: Komiyama Yutaka 
Published: October 2019

AbstractWe have carried out a wide and deep imaging survey for the Local Group dwarf spheroidal galaxy Ursa Minor (UMi) using Hyper Suprime-Cam (HSC). The data cover out beyond the nominal tidal radius down to ~25 mag in i band, which is ~2 mag below the main sequence turn-off point. The structural parameters of UMi are derived using red giant branch (RGB) stars and sub-giant branch (SGB) stars, and the tidal radius is suggested to be larger than those estimated by the previous studies. It is also found that the distribution of bluer RGB/SGB stars is more extended than that of redder RGB/SGB stars. The fraction of binary systems is estimated to be ~0.4 from the morphology of the main sequences.
Multiple Absorption Systems in the Lines of Sight to Quadruply Lensed Quasar H1413+1143 As a Probe of the Circumgalactic medium around Dwarf Galaxy
Authors: Okoshi Katsuya , Minowa Yosuke , Kashikawa Nobunari , Koyamada Suzuka , Misawa Toru 
Published: October 2019

AbstractWe present the first measurement of differences in MgII absorption strength in multiple intervening absorbers, which are also identified as (sub-)Damped Lyman alpha absorption systems, in the four spectra of the quadruply lensed quasar H1413+1143, often referred to the “Cloverleaf”, from highly spatial resolution and high signal-to-noise spectroscopy with an optical multi-mode spectrograph, the Kyoto tridimentional spectrograph II on board the Subaru telescope. The detection of significant MgII absorptions in multiple components in the spatially-resolved spectra suggests that chemical enrichment differs at least on scale of about 10 kpc within the separation of sightlines. For, a DLA system at redshift zabs = 1.66, the rest equivalent widths of MgII absorption lines change by factors up to 6, which is similar to those of HI absorption lines. This suggests that (inhomogeneous) cold absorbers which give rise to strong HI/MgII absorptions dwell on a scale within 10 kpc in the circumgalactic medium (CGM).
Dwarf Galaxies in the Core of Coma Cluster
Authors: Hasan S. N. , Shah Priya , Nagamani P. 
Published: October 2019

AbstractDwarf galaxies constitute 18% of the galaxies in the core of the Coma Cluster. We present the correlation between structural properties and morphology of galaxies in the central region of Coma Cluster for 221 objects within the apparent magnitude range m < 19.5. The data is taken from the HST/ACS Coma Cluster Treasury Survey. For cluster membership we have used photometric redshifts and spectroscopic redshifts from literature. From the investigation of correlations of effective radius, Sersic index, absolute magnitude and bulge to total light ratio, we find the galaxies are distributed as follows: dwarfs 18%, E/SO 33%, SO 22%, Sb & Sb0 17% and 10% are Spirals+Irregulars+Ring. We found that multiple component fits are best for giants and the single Sersic fit is best for dwarfs & spiral galaxies. We shall try to explain why the single Sersic fit is best for dwarfs and what kind of stellar orbits do they correspond to using the bulge Sersic index of dwarfs.
Numerical computation of gravitational field of infinitely-thin axisymmetric disc with arbitrary surface mass density profile and its application to preliminary study of rotation curve of M33
Authors: Fukushima Toshio 
Published: October 2019

AbstractWe developed a numerical method[-70pt] to compute the gravitational field of an infinitely-thin axisymmetric disc with an arbitrary surface mass density profile. We evaluate the gravitational potential by a split quadrature using the double exponential rule and obtain the acceleration vector by numerically differentiating the potential by Ridders’ algorithm. By using the new method, we show the rotation curves of some non-trivial discs: (i) truncated power-law discs, (ii) discs with a non-negligible center hole, (iii) truncated Mestel discs with edge-softening, (iv) double power-law discs, (v) exponentially-damped power-law discs, and (vi) an exponential disc with a sinusoidal modulation of the density profile. Also, we present a couple of model fittings to the observed rotation curve of M33: (i) the standard deconvolution by assuming a spherical distributin of the dark matter and (ii) a direct fit of infinitely-thin disc mass with a double power-law distribution of the surface mass density.
Diffuse post-starburst galaxies: a smoking gun of formation of ultra-diffuse galaxies via ram pressure stripping
Authors: Chilingarian Igor V. , Grishin Kirill A. , Afanasiev Anton V. , Fabricant Daniel , Katkov Ivan Yu. 
Published: October 2019

AbstractUltra-diffuse galaxies (UDGs) have sizes comparable to the Milky Way and stellar masses of about 1/1000 of it. They attracted a lot of attention as possible “dark galaxies” heavily dominated by dark matter, however, no reliable dynamical mass estimates were done because of their extremely low surface brightness. We have recently found 13 gas free diffuse young (300–500 Myr) post-starburst galaxies (PSGs) without ongoing star formation in Coma and Abell 2147, which, should they continue to evolve passively, will become UDGs in 5 Gyr. We obtained deep spectroscopic observations for 11 diffuse PSGs and derived their internal kinematics and stellar population properties. All of them possess disk-like kinematics (substantial rotation, low stellar velocity dispersion) and likely experienced starburst episodes prior to the star formation quenching by ram pressure stripping. Our results suggest that at least some UDGs were “normal” intermediate to large-sized disk galaxies in the past, which were later quenched by dense environment.
Outlying Hα blobs in SDSS IV MaNGA
Authors: Bait Omkar , Wadadekar Yogesh , Barway Sudhanshu 
Published: October 2019

AbstractWe have discovered a population of 29 outlying Hα emitters which appear like unresolved blobs in the DR14 data release of the SDSS IV MaNGA integral field unit survey. They do not have any underlying optical continuum emission in deep imaging from the DECam Legacy Survey or Beijing-Arizona Sky Survey. These blobs either lie away from the disc of the host galaxy in the MaNGA IFU and/or have velocities which are different from the velocity map of the host galaxy. Interestingly, all of them show photoionisation due to star formation. These galaxies have very high specific star formation rates compared to the known population of dwarf galaxies. However, their metallicities are consistent with or even lowerthan those of the local volume dwarfs. Thus, we can possibly rule out tidal dwarf galaxies. They could represent a new population of low mass and starbursting dwarf galaxies.
Zippered Shear Zone Model for Interacting Shear Zones in the Borborema Province, Brazil, as Constrained by U‐Pb Dating
Authors: Ávila Carlos F. , Archanjo Carlos J. , Fossen Haakon , Hollanda Maria Helena B. M. 
Published: October 2019

AbstractShear zones typically interact to form connected systems or networks to accommodate crustal deformation, but our knowledge of how this happens is fragmentary. Understanding branching and interacting shear zones requires knowledge of timing, deformation kinematics, and rheology. The Senador Pompeu, Tauá, and Cococi strike‐slip shear zones of the Borborema Province (NE Brazil) have a central role and location in the Neoproterozoic assembly of Gondwana and provide a means to understand shear zone interaction. We apply (i) U‐Pb in situ SHRIMP analysis of zircons from syntectonic plutons and dykes to constrain the timing of shearing and (ii) vorticity and strain analysis on pluton's megacrystic facies deformed in the magmatic state and during final stages of crystallization. Obtained ages show that the shear zone pair was active under high temperature at 583.5±4.6 Ma, while felsic dykes were emplaced in the brittle regime in the wall rocks. Average vorticity estimates of 0.70 indicate a strong component of pure shear in the shear zones. Despite the transpressional character, the dispersion in estimates of thinning and thickening for the Senador Pompeu shear zone highlights variations of offset rate for the interacting branches that leads to localized transtension. We conclude that the kinematic framework of the Senador Pompeu and Tauá conjugate pair involves the formation of a dextrally closing zipper structure involving the trailing Cococi shear zone to the southwest, which in turn caused the northeastward extrusion of the enclosed crustal wedge and possibly activation of the nappe system of the Ceará Central domain.
Visualization tools for human structural variations identified by whole-genome sequencing
Authors: Yokoyama Toshiyuki T. , Kasahara Masahiro 
Published: October 2019

AbstractVisualizing structural variations (SVs) is a critical step for finding associations between SVs and human traits or diseases. Given that there are many sequencing platforms used for SV identification and given that how best to visualize SVs together with other data, such as read alignments and annotations, depends on research goals, there are dozens of SV visualization tools designed for different research goals and sequencing platforms. Here, we provide a comprehensive survey of over 30 SV visualization tools to help users choose which tools to use. This review targets users who wish to visualize a set of SVs identified from the massively parallel sequencing reads of an individual human genome. We first categorize the ways in which SV visualization tools display SVs into ten major categories, which we denote as view modules. View modules allow readers to understand the features of each SV visualization tool quickly. Next, we introduce the features of individual SV visualization tools from several aspects, including whether SV views are integrated with annotations, whether long-read alignment is displayed, whether underlying data structures are graph-based, the type of SVs shown, whether auditing is possible, whether bird’s eye view is available, sequencing platforms, and the number of samples. We hope that this review will serve as a guide for readers on the currently available SV visualization tools and lead to the development of new SV visualization tools in the near future.
Gadd45β promotes regeneration after injury through TGFβ-dependent restitution in experimental colitis
Authors: Hwang Jung Hwan , Kim Tae-Hwan , Kim Yong-Hoon , Noh Jung-Ran , Choi Dong-Hee , Kim Kyoung-Shim , Lee Eun-Young , Kim Byoung-Chan , Kim Myung Hee , Kim Ho , Lee Tae Geol , Lee Jong-Soo , Lee Chul-Ho 
Published: October 2019

AbstractDysregulated immune responses and impaired function in intestinal epithelial cells contribute to the pathogenesis of inflammatory bowel disease (IBD). Growth arrest and DNA damage-inducible 45 beta (Gadd45β) has been implicated in the pathogenesis of various inflammatory symptoms. However, the role of Gadd45β in IBD is completely unknown. This study aimed to evaluate the role of Gadd45β in IBD. Gadd45β-KO mice exhibited drastically greater susceptibility to dextran sulfate sodium (DSS)-induced colitis and mortality than C57BL/6J mice. Bone marrow transplantation experiments revealed that Gadd45β functions predominantly in the intestinal epithelium and is critical during the recovery phase. Gadd45β regulates the TGF-β signaling pathway in colon tissue and epithelial cells by inhibiting Smurf-mediated degradation of TGF-β receptor type 1 via competitive binding to the N-terminal domain of Smad7. Furthermore, these results indicate that the Gadd45β-regulated TGF-β signaling pathway is involved in wound healing by enhancing epithelial restitution. These results expand the current understanding of the function of Gadd45β and its therapeutic potential in ulcerative colitis.
Exploration of intermediate-sized INDELs by next-generation multigene panel testing in Han Chinese patients with breast cancer
Authors: Hata Chihiro , Nakaoka Hirofumi , Xiang Yu , Wang Dong , Yang Anping , Liu Dahai , Liu Fang , Zou Qingfeng , Zheng Ke , Inoue Ituro , You Hua 
Published: October 2019

AbstractMultigene panel testing via next-generation sequencing focuses on the detection of small-sized mutations, such as single nucleotide variants and short insertions and deletions (INDELs). However, intermediate-sized INDELs have not been fully explored due to technical difficulties. Here, we performed bioinformatics analyses to identify intermediate-sized INDELs in 54 cancer-related genes from 583 Han Chinese patients with breast cancer. We detected a novel deletion–insertion in a translational variant of PTEN (also known as PTENα) in one patient.
Early detection and staging of chronic liver diseases with a protein MRI contrast agent
Authors: Salarian Mani , Turaga Ravi Chakra , Xue Shenghui , Nezafati Maysam , Hekmatyar Khan , Qiao Jingjuan , Zhang Yinwei , Tan Shanshan , Ibhagui Oluwatosin Y. , Hai Yan , Li Jibiao , Mukkavilli Rao , Sharma Malvika , Mittal Pardeep , Min Xiaoyi , Keilholz Shella , Yu Liqing , Qin Gengshen , Farris Alton Brad , Liu Zhi-Ren , Yang Jenny J. 
Published: October 2019

AbstractEarly diagnosis and noninvasive detection of liver fibrosis and its heterogeneity remain as major unmet medical needs for stopping further disease progression toward severe clinical consequences. Here we report a collagen type I targeting protein-based contrast agent (ProCA32.collagen1) with strong collagen I affinity. ProCA32.collagen1 possesses high relaxivities per particle (r1 and r2) at both 1.4 and 7.0 T, which enables the robust detection of early-stage (Ishak stage 3 of 6) liver fibrosis and nonalcoholic steatohepatitis (Ishak stage 1 of 6 or 1 A Mild) in animal models via dual contrast modes. ProCA32.collagen1 also demonstrates vasculature changes associated with intrahepatic angiogenesis and portal hypertension during late-stage fibrosis, and heterogeneity via serial molecular imaging. ProCA32.collagen1 mitigates metal toxicity due to lower dosage and strong resistance to transmetallation and unprecedented metal selectivity for Gd3+ over physiological metal ions with strong translational potential in facilitating effective treatment to halt further chronic liver disease progression.
Convergent evolution of face spaces across human face-selective neuronal groups and deep convolutional networks
Authors: Grossman Shany , Gaziv Guy , Yeagle Erin M. , Harel Michal , Mégevand Pierre , Groppe David M. , Khuvis Simon , Herrero Jose L. , Irani Michal , Mehta Ashesh D. , Malach Rafael 
Published: October 2019

AbstractThe discovery that deep convolutional neural networks (DCNNs) achieve human performance in realistic tasks offers fresh opportunities for linking neuronal tuning properties to such tasks. Here we show that the face-space geometry, revealed through pair-wise activation similarities of face-selective neuronal groups recorded intracranially in 33 patients, significantly matches that of a DCNN having human-level face recognition capabilities. This convergent evolution of pattern similarities across biological and artificial networks highlights the significance of face-space geometry in face perception. Furthermore, the nature of the neuronal to DCNN match suggests a role of human face areas in pictorial aspects of face perception. First, the match was confined to intermediate DCNN layers. Second, presenting identity-preserving image manipulations to the DCNN abolished its correlation to neuronal responses. Finally, DCNN units matching human neuronal group tuning displayed view-point selective receptive fields. Our results demonstrate the importance of face-space geometry in the pictorial aspects of human face perception.