bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of Revision surgery for surgically treated insertional Achilles tendinopathy
Authors: Hörterer Hubert , Oppelt Sonia , Pfahl Kathrin , Harrasser Norbert , Böcker Wolfgang , Polzer Hans , Walther Markus , Baumbach Sebastian Felix 
Published: December 2024

Abstract
Introduction
There is a clear roadmap for the treatment of primary insertional Achilles tendinopathy (IAT), but data on the outcome of revision surgery is missing. The current study aimed to analyze the outcome following revision surgery for surgically failed IAT.

Material and methods
Included were patients with IAT revision surgery at a single reference center (01/2010–10/2016) and a follow-up of at least 12 months. Revision surgery was performed, whenever possible, through a midline incision transachillary approach (MITA) with debridement of all pathologies present. The patient-rated outcome was assessed per the FFI (preoperative, final follow-up) and VISA-A-G (final follow-up). The aim was to evaluate the patient rated outcome following revision surgery for recurrent IAT.

Results
Out of 24 eligible patients, 19 (79%) were included in the final follow-up. The mean follow-up duration was 4.6 ± 2.2 years. The FFI Overall improved from preoperatively 68 ± 19 to 14 ± 17 points (< 0.001) at the final follow-up. The final VISA-A-G was 71 ± 28 points. 39%/36% (FFI/VISA-A-G) of patients reached patient-rated outcome scores comparable to a healthy reference population. No factors could be identified to influence the outcome significantly.

Conclusion
IAT revision surgery results in an improvement of the patients’ symptoms, but only one-third of the patients recover fully.
Interpretable deep learning survival predictions in sporadic Creutzfeldt–Jakob disease
Authors: Tam Johnny , Centola John , Kurucu Hatice , Watson Neil , MacKenzie Janet , Green Alison , Summers David , Barria Marcelo , Seth Sohan , Smith Colin , Pal Suvankar 
Published: December 2024

Abstract

Background
Sporadic Creutzfeldt–Jakob disease (sCJD) is a rapidly progressive and fatal prion disease with significant public health implications. Survival is heterogenous, posing challenges for prognostication and care planning. We developed a survival model using diagnostic data from comprehensive UK sCJD surveillance.

Methods
Using national CJD surveillance data from the United Kingdom (UK), we included 655 cases of probable or definite sCJD according to 2017 international consensus diagnostic criteria between 01/2017 and 01/2022. Data included symptoms at diagnosis, CSF RT-QuIC and 14-3-3, MRI and EEG findings, as well as sex, age, PRNP codon 129 polymorphism, CSF total protein and S100b. An artificial neural network based multitask logistic regression was used for survival analysis. Model-agnostic interpretation methods was used to assess the contribution of individual features on model outcome.

Results
Our algorithm had a c-index of 0.732, IBS of 0.079, and AUC at 5 and 10 months of 0.866 and 0.872, respectively. This modestly improved on Cox proportional hazard model (c-index 0.730, IBS 0.083, AUC 0.852 and 0863) but was not statistically significant. Both models identified codon 129 polymorphism and CSF 14-3-3 to be significant predictive features.

Conclusions
sCJD survival can be predicted using routinely collected clinical data at diagnosis. Our analysis pipeline has similar levels of performance to classical methods and provide clinically meaningful interpretation which help deepen clinical understanding of the condition. Further development and clinical validation will facilitate improvements in prognostication, care planning, and stratification to clinical trials.
Curriculum interventional cardiology—Austria
Authors: Kammerlander A. , Berger R. , Binder R. K. , Dörler J. , Frick M. , Gremmel T. , Mader A. , Kammler J. , Rab A. , Geppert A. , Schober A. , Niessner A. 
Published: December 2024

SummaryThe curriculum for interventional cardiology outlines a structured training program for advanced training in interventional procedures. It specifies requirements for candidates, trainers, and centers. The curriculum specifically defines learning objectives, competence levels, and essential skills needed for on-duty shift in the catheterization laboratory. The program is based on the European Core Curriculum, tailored to Austrian healthcare needs, and aims to ensure high-quality care.
‘Eating with Others’: planning, developing and optimising a self-management intervention to promote social eating for patients living with and beyond head and neck cancer
Authors: Dornan D. M. , Semple C. J. , Moorhead A. 
Published: December 2024

Abstract

Introduction
After treatment for head and neck cancer (HNC), up to 90% of patients have difficulties eating and drinking. Despite the enormity of challenges explicitly relating to the social dimension of eating, there are limited extant interventions to specifically support social eating, nor any replicable for use in contemporary clinical practice. This study aims to plan, develop and optimise a self-management intervention to promote social eating for patients living with and beyond HNC.

Methods
This research was intervention development of a self-management ‘Eating with Others’ resource, guided by the person-based approach (PBA) framework. Initially, a systematic review was conducted, with 24 included studies exploring HNC patients’ social eating experiences, followed by thematically analysed qualitative interviews with patients (n = 14), family members (n = 12) and healthcare professionals (n = 13). Alongside this data, iterative input was sought from an advisory group (n = 22) to culminate in an intervention prototype. The intervention prototype was iteratively user-tested over three cycles for usability and acceptability, using think-aloud interviews (n = 10).

Results
A patient-centred, evidence-based and theory-driven self-management resource, entitled ‘Eating with Others’, was designed to promote social eating for patients with HNC. Sections included the benefits of social eating; the impact of HNC on social eating, strategies and reflective activities to overcome social eating barriers; and the use of a social eating card for restaurants. The think-aloud interviews revealed that the resource was appropriate and acceptable for patients with HNC.

Conclusion
The systematic and iterative PBA intervention development framework enabled empirical research findings, relevant theory and extensive advisory group involvement to design an acceptable self-management social eating intervention for patients living with and beyond HNC. Mixed-methods evaluation is required to determine feasibility in clinical practice.
Cancer prognosis information-seeking among survivors and caregivers: findings from the National Cancer Institute’s Cancer Information Service
Authors: Wilson Ashley , Huang Grace , Kueppers George , Dwyer Laura A. , Han Paul K. J. , Vanderpool Robin C. 
Published: December 2024

Abstract

Purpose
Receiving prognostic information is a well-documented need for cancer survivors and caregivers. However, little is known about these two groups’ prognosis information-seeking outside of discussions with healthcare providers. This study examined survivors’ and caregivers’ prognosis-related inquiries using data from the National Cancer Institute’s Cancer Information Service (CIS).

Methods
Using an analytic sample of 81,154 survivors and caregivers, descriptive statistics explored differences between prognosis and non-prognosis inquiries made by each group over a 6-year period (September 2018–August 2024). Logistic regressions identified factors that were associated with odds of a prognosis inquiry among both cancer survivors and caregivers.

Results
A higher proportion of caregivers (62%) made prognosis inquiries to the CIS compared to survivors (38%). Among both groups, telephone and instant chat were commonly used to contact the CIS with prognosis questions. Prognosis inquiries were more likely among survivors and caregivers who contacted the CIS in Spanish and whose inquiries centered on staging, post-treatment, or end-of-life phases of the cancer continuum. For both groups, prognosis inquiries were more likely to occur in the context of discussions about chemotherapy and general questions about cancer treatment. Discussion of prognosis as related to specific cancer sites was variable across survivors and caregivers.

Conclusion
Findings may inform the development and targeting of messages to support cancer prognosis information-seeking among survivors and caregivers. Disseminating accessible, language-concordant prognostic information that accounts for survivors’ and caregivers’ respective information-seeking needs is merited. Efforts may contribute to enhancing prognostic understanding, supporting discussions with providers, and improving psychosocial outcomes.
Estimation of orange tree production by regression from video segments under uncontrolled conditions
Authors: Mollineda Ramón A. , Sandoval Javier , Rodríguez Christian D. , Heredia José A. 
Published: December 2024

Abstract
Precision agriculture covers a wide range of information and communications technologies aimed at supporting current challenges in crop estimation, productivity increase, and food security. In particular, crop yield estimation can provide very valuable information on crop distribution, with the aim of optimising logistics and harvest timing. This paper focuses on deep learning-based regression solutions for estimating the number of visible oranges on trees, from real-world crop row videos captured by a camera placed on a farm vehicle. Count predictions based on individual frames were compared with those based on variable size sequences of frames centred on each tree (video segments). The performance of three deep neural networks designed for regression was evaluated in terms of the regression error and the uncertainty of the estimates, and differences were analysed using nonparametric hypothesis testing. Experiments were conducted on a new dataset composed of annotated video segments of orange tree rows acquired under uncontrolled conditions, which has been made publicly available. Results statistically prove the value of considering multiple frames and the feasibility of yield estimation by regression in the wild. These findings are expected to contribute to optimising decision-making in crop resource management. Unlike most efforts so far, which involve counting fruits by detection in tree images usually captured manually, this work explores counting fruits by regression on trees from real-world video data.
Is arbuscular mycorrhizal fungal addition beneficial to potato systems? A meta-analysis
Authors: Oladele Segun , Gould Iain , Varga Sandra 
Published: December 2024

AbstractThe application of arbuscular mycorrhizal (AM) fungi has been reported to confer multiple agronomic benefits to crop plants including cereals, vegetables, and fruit trees, as well as to improve soil structure and health. In this study, we conducted a meta-analysis to investigate whether AM fungal addition enhances potato yield. We further examined whether several experimental conditions (type of experiment, inoculation method, and source of AM fungi) and potato cultivar may explain the outcomes. We calculated the effect sizes of seven plant parameters by including a total of 106 independent pot and field experimental studies from 37 peer reviewed publications. Our results show that the addition of AM fungi has an overall positive effect on all potato plant parameters included in our analyses except for aboveground plant biomass. Potato cultivar was the main significant moderator explaining our findings, with some cultivars benefiting more from AM fungal presence than others. Our findings agree with several other global meta-analyses reporting positive effects of AM fungi on other important crops and highlights the potential application of these fungal symbionts in potato agro-ecosystems.
Evaluating the impact of atezolizumab on febrile neutropenia occurrence in patients with NSCLC undergoing chemotherapy in Japan: a real-world post-marketing database study
Authors: Nakane Sayuri , Yuri Akinori , Miyano Yuki , Yamada Kana , Nakatsuji Erika , Takei Nobuki , Igarashi Yasuhiro , Harada Ryousuke 
Published: December 2024

Abstract

Background
Febrile neutropenia (FN) is a recognised adverse event associated with chemotherapy. This study investigates the impact of atezolizumab, an immune checkpoint inhibitor, on the incidence of FN in patients with non-small cell lung cancer receiving concurrent chemotherapy in Japan.

Methods
This post-marketing database study was conducted using data from patients with non-small cell lung cancer provided by Medical Data Vision Co., Ltd. covering April 2008 to present. The primary outcome measured was FN incidence, and its causal association with atezolizumab use was examined by comparing the atezolizumab plus bevacizumab plus carboplatin plus paclitaxel [ABCP])-containing regimen to the BCP control group. The data period was from 1 September, 2015, to 31 December, 2021, including approval date of this drug, 21 December, 2018.

Results
The database identified 301 subjects for the ABCP regimen (exposure) group, 44 for the BCP regimen (cohort design control) group during the same period, and 207 for BCP regimen (historical cohort design control) group before the approval of atezolizumab. For historical cohort design, the incidence and adjusted incidence ratios of febrile neutropenia in the exposure group to the control group were 6.13 (95% CI 2.78–13.49) and 8.19 (95% CI 3.79–25.33), respectively. Sensitivity analysis showed FN occurred in 17% (52/301) of the exposure group, 4.5% (2/44) of the cohort design control group, and 3% (7/207) of the historical cohort design control group.

Conclusions
The incidence of FN was higher in the exposure group. Considering the study results, special caution is needed for FN occurrence in patients receiving atezolizumab.
Treatment-related skin reactions in enfortumab vedotin as a surrogate marker of survival and treatment response
Authors: Nagayama Jun , Inoue Satoshi , Sai Hiroki , Hayakawa Akira , Yuguchi Yuri , Suzuki Tomohide , Matsui Hirotaka , Yuba Takuma , Morishita Koya , Akamatsu Shusuke 
Published: December 2024

Abstract

Background
Treatment-related skin reactions (TRSRs) induced by enfortumab vedotin (EV) targeting nectin-4 are among the most common adverse events. However, their association with survival and treatment response is poorly understood.

Methods
We retrospectively identified patients who received EV from December 2021 to April 2023 at Nagoya University Hospital and its affiliated facilities and extracted clinical data from their medical records. We evaluated cancer-specific survival (CSS) and progression-free survival (PFS) as survival outcomes and overall response rate (ORR) and disease control rate (DCR) as treatment responses between patients with and without TRSRs.

Results
In total, 67 eligible patients were identified. Thirty-four patients experienced TRSRs, and the remaining 33 did not experience TRSRs. The median follow-up period was 8 months. Patients in the TRSRs group demonstrated significantly longer median CSS (15 vs. 8 months; p = 0.003) and median PFS (10 vs. 5 months; p < 0.001) than the non-TRSRs. Regarding treatment response, the patients in the TRSRs group showed a favorable, albeit nonsignificant, treatment response trend compared with those in the non-TRSRs group (ORR, 73.5% vs. 51.5%; p = 0.107; DCR, 91.2 % vs. 81.8%; p = 0.444).

Conclusions
Patients with TRSRs demonstrated more prolonged survival and superior treatment responses to EV treatment. The role of TRSR as a surrogate marker of EV’s efficacy should be further explored in prospective and sufficiently powered studies.
The health-economic impact of urine albumin-to-creatinine ratio testing for chronic kidney disease in Japanese non-diabetic patients
Authors: Konta Tsuneo , Asahi Koichi , Tamura Kouichi , Tanaka Fumitaka , Fukui Akira , Nakamura Yusuke , Hirose Junichi , Ohara Kenichi , Shijoh Yoko , Carter Matthew , Meredith Kimberley , Harris James , Åkerborg Örjan , Kashihara Naoki , Yokoo Takashi 
Published: December 2024

Abstract
Background
The objective of this analysis was to estimate the clinical and economic impact of undertaking urine albumin-to-creatinine ratio (UACR) testing alongside regular estimated glomerular filtration rate testing for chronic kidney disease in non-diabetic Japanese patients versus no testing and versus urine protein-creatinine ratio (UPCR) testing.

Methods
An economic model, taking a Japanese healthcare perspective, estimated the health-economic impact of UACR testing over a lifetime time horizon. Outcomes reported were additional costs, clinical benefits measured, such as prevented dialyses and cardiovascular events, quality-adjusted life years gained, and incremental cost-effectiveness ratios. Health states were derived from risk levels reported in the Kidney Disease: Improving Global Outcomes heatmap. Results were derived assuming that after testing, treatment was available in the form of current standard-of-care or emerging chronic kidney disease therapies.

Results
Repeated UACR testing was found to be cost-effective compared to both no urine testing and UPCR testing, with incremental cost-effectiveness ratios of ¥1,953,958 and ¥1,966,433, respectively.

Conclusion
Overall, this model demonstrates the health-economic value of undertaking UACR testing within the non-diabetic Japanese population.
Basic immunization against diphtheria, tetanus and pertussis within the at-risk population of oncological patients: cross-sectional data from the Berlin Metropolitan area
Authors: Koberschinski Jonas Janik Ralf , Reinwald Mark , de Wit Maike , Kiderlen Til Ramón 
Published: December 2024

Abstract
Aim
Oncological patients are susceptible to severe infectious complications, some of which may be preventable through vaccination. Vaccination rates among oncological patients are generally considered low. While prevalence data on basic immunization for diphtheria, tetanus and pertussis among the general population is available in Germany, such data remains lacking for oncological patients. With this publication, we aim to present the first data.

Subject and methods
In this study, we examined data collected during the EVO intervention study to assess participants’ vaccination status against DTP. Our analysis focused on the baseline data of all participants and the follow-up data of the control group, thereby excluding data affected by the intervention. We used Pearson’s chi-squared test to explore factors potentially associated with higher or lower vaccination rates (e.g. sex, diagnosis).

Results
Of the 370 patients included in the study, 78.9% had a solid and 21.1% a haematological tumour; 47.3% were vaccinated against tetanus, 44.9% against diphtheria and 39.7% against pertussis. Patients with haematological cancer had a higher vaccination rate against diphtheria compared to those with solid tumour (55.1% vs. 42.1%). On the other hand, women had higher rates compared to men against tetanus (53.7% vs. 40.7%) and diphtheria (50.0% vs. 39.4%). Additional positive factors included the presence of autoimmune diseases and a diagnosis of multiple myeloma.

Conclusion
Oncological patients seem to have significantly lower vaccination rates for diphtheria and tetanus compared to the German general population. For pertussis, on the other hand, the vaccination rate is higher than in the general population.
Non-Abelian Extensions of Groupoids and Their Groupoid Rings
Authors: Machado Natã , Öinert Johan , Wagner Stefan 
Published: December 2024

Abstract
We present a geometrically oriented classification theory for non-Abelian extensions of groupoids generalizing the classification theory for Abelian extensions of groupoids by Westman as well as the familiar classification theory for non-Abelian extensions of groups by Schreier and Eilenberg-MacLane. As an application of our techniques we demonstrate that each extension of groupoids

$${\mathcal {N}}\rightarrow {\mathcal {E}}\rightarrow {\mathcal {G}}$$

N
→
E
→
G

gives rise to a groupoid crossed product of

$${\mathcal {G}}$$

G

by the groupoid ring of

$${\mathcal {N}}$$

N

which recovers the groupoid ring of

$${\mathcal {E}}$$

E

up to isomorphism. Furthermore, we make the somewhat surprising observation that our classification methods naturally transfer to the class of groupoid crossed products, thus providing a classification theory for this class of rings. Our study is motivated by the search for natural examples of groupoid crossed products.
HFL-GAN: scalable hierarchical federated learning GAN for high quantity heterogeneous clients
Authors: Petch Lewis , Moustafa Ahmed , Ma Xinhui , Yasser Mohammad 
Published: December 2024

Abstract
This paper introduces a novel approach for training generative adversarial networks using federated machine learning. Generative adversarial networks have gained plenty of attention in the research community especially with their abilities to produce high quality synthetic data for a variety of use-cases. Yet, when combined with federated learning, those models suffer from degradation in both training time and quality of results. To address this challenge, this paper introduces a novel approach that uses hierarchical learning techniques to enable the efficient training of federated GAN models. The proposed approach introduces an innovative mechanism that dynamically clusters participant clients to edge servers as well as a novel multi-generator GAN architecture that utilizes non-identical model aggregation stages. The proposed approach has been evaluated on a number of benchmark datasets to measure its performance on higher numbers of participating clients. The results show that HFL-GAN outperforms other comparative state-of-the-art approaches in the training of GAN models in complex non-IID federated learning settings.
Cohort profile: Guangzhou breast cancer study (GBCS)
Authors: Wang Jiao , Li Na , Xiao Cheng Kun , Han Shu Shu , Lu Min Jie , Lin Xiao Yi , Ren Ze Fang , Xu Lin 
Published: December 2024

AbstractThe Guangzhou Breast Cancer Study (GBCS) is a patient-based prospective cohort study designed to identify risk factors and underlying mechanisms for breast cancer (BC) incidence and prognosis, specifically addressing the need for individualized prevention in South China, where BC incidence is notably high. Based in Guangzhou, China, the GBCS began recruitment in 2008, comprises three complementary studies: the Guangzhou breast cancer cohort with 5471 breast cancer patients, a case–control study with 1551 cases and 1605 controls, and an immunohistochemistry (IHC) cohort with 1063 breast cancer patients. Participants are primarily aged 41–60 years. Cohort follow-up is conducted every three months in the first year, every six months in the second and third years, and annually thereafter. High follow-up rates have been achieved until 2023, with 73.5% for the Guangzhou breast cancer cohort and 98.6% for the IHC cohort still active. Baseline data collection included demographic characteristics and breast cancer risk factors, while follow-up data included survival, treatment details, disease history, occupational history, post-diagnostic lifestyle, and laboratory measures, including genetic markers, proteins, and environmental exposures. The study encourages global collaborations and invites interested researchers to contact the corresponding author at xulin27@ mail.sysu.edu.cn with specific research ideas or proposals.