bluuebunny/crossref_metadata_2025_split huggingface dataset:
Practical approach to COVID-19: an Egyptian pediatric consensus
Authors: Mostafa Abla S. , Abdalbaky Ashraf , Fouda E. M. , Shaaban Hala H. , Elnady Hala G. , Hassab-Allah Magda , Rashad Mohamed M. , El Attar Mona M. , Alfishawy Mostafa , Hussien Shahenaz M. , Hamed Tarek , Hamed Dina H. , Sarhan Dina T. 
Published: August 2020

Abstract
Background
Outbreak of a novel corona virus was reported in China on December 2019. Sooner, a global spread was reported and WHO announced a public health emergency of international concern and then declared it as a pandemic. Egypt announced the first case on February 14, 2020, and since that time, cases are increasing.

Main body
There is increasing need to simplify the practical approach for pediatricians and other health care workers in a step wise manner; how to deal with COVID-19 cases, how to care for the newborn babies as regards to breastfeeding, and how to ensure safety of health care workers assess their risk of infection and management accordingly. A national practical approach guideline was prepared including case definition, diagnosis, and management of pediatric COVID-19 suspected and confirmed cases in an algorithmic pattern.

Conclusion
Up to the current knowledge, this is a simple and practical guidance for clinical management of children during the current pandemic.
COVID-19 variant radiological findings with high lightening other coronavirus family (SARS and MERS) findings: radiological impact and findings spectrum of corona virus (COVID-19) with comparison to SARS and MERS
Authors: Kolta Marian Fayek , Ghonimy Mai Bahgat Ibrahim 
Published: August 2020

Abstract
Background
Chest CT is remarkably considered as an imminent diagnostic tool and follow-up study in pulmonary changes in COVID-19 patients; being familiar to other coronavirus family CT findings, this improve our diagnostic experience and hence enhance our ability to early diagnose and combat the outbreak of COVID-19. The purpose is to investigate the wide spectrum of radiological pulmonary changes in COVID-19 patients and compare them to the variable CT findings reported in MERS and SARS.

Results
From March 15 to May 12, 2020, 50 patients in Cairo, Egypt, who have positive RT-PCR tests, were included in our study. MSCT of the chest was performed to all patients and processed in a separate work station. Two experienced radiologists assessed each study for the type and location of different pulmonary affection.
The most imminent radiological finding was patchy peripheral subpleural ground glass opacity found in 42 patients (84% of cases), followed by consolidation found in 30 patients (60% of cases) and ground glass and consolidation together found in 22 patients (44% of cases).
Unlike SARS, where initial chest imaging abnormalities are more frequently unilateral, COVID-19 is more likely to involve both lungs on initial imaging presented as bilateral peripheral subpleural scattered ground-glass opacities.
Pleural effusion is absent in COVID-19 patients while it is not rare in MERS and might be observed in 20–33% of affected individuals.

Conclusion
The imaging features of COVID-19 pneumonia are highly sensitive mainly in the outbreak pandemic.
The imaging features of SARS, MERS, and COVID-19 overlap, but differences still exist especially early in disease course.
Intraspecific mitochondrial gene variation can be as low as that of nuclear rRNA
Authors: Matumba Tshifhiwa G. , Oliver Jody , Barker Nigel P. , McQuaid Christopher D. , Teske Peter R. 
Published: August 2020

Background: Mitochondrial DNA (mtDNA) has long been used to date historical demographic events. The idea that it is useful for molecular dating rests on the premise that its evolution is neutral. Even though this idea has long been challenged, the evidence against clock-like evolution of mtDNA is often ignored. Here, we present a particularly clear and simple example to illustrate the implications of violations of the assumption of selective neutrality. Methods: DNA sequences were generated for the mtDNA COI gene and the nuclear 28S rRNA of two closely related rocky shore snails, and species-level variation was compared. Nuclear rRNA is not usually used to study intraspecific variation in species that are not spatially structured, presumably because this marker is assumed to evolve so slowly that it is more suitable for phylogenetics. Results: Even though high inter-specific divergence reflected the faster evolutionary rate of COI, intraspecific genetic variation was similar for both markers. As a result, estimates of population expansion times based on mismatch distributions differed between the two markers by millions of years. Conclusions: Assuming that 28S evolution is more clock-like, these findings can be explained by variation-reducing purifying selection in mtDNA at the species level, and an elevated divergence rate caused by diversifying selection between the two species. Although these two selective forces together make mtDNA suitable as a marker for species identifications by means of DNA barcoding because they create a ‘barcoding gap’, estimates of demographic change based on this marker can be expected to be highly unreliable. Our study contributes to the growing evidence that the utility of mtDNA sequence data beyond DNA barcoding is limited.
Predictors of presumptive treatment of uncomplicated malaria among children in private retail outlets in Kenya: mixed effects logistic regression modelling
Authors: Omache Diana , Owuor Nelson , Machini Beatrice 
Published: August 2020

Background: The health seeking behavior in Kenya raises concerns in malaria case management at the private sector. Adherence to the national guidelines for the diagnosis, treatment and prevention of malaria is key in management of the disease. Presumptive treatment remains a major challenge in Kenya, especially in the private sector, with major gaps in literature identified on predictors of this treatment. Mixed-effects regression modelling considers county clustering, is more accurate in prediction and is more efficient and flexible. Methods: The study design was a cross-sectional, nationally representative, retail outlet survey secondary data analysis. The study populations included the health care providers in the retail outlets sampled randomly in both the rural and urban settings in Kenya. The primary outcome of interest was the proportion of health care providers who treated patients presumptively. Multivariable analysis was conducted for the significant variables, adjusting for clustering at the county level to determine the predictors of presumptive treatment. The best fitting model was examined using the Akaike Information Criterion (AIC). Results: Out of the 333 health care providers who treated patients, 190 (57%) treated patients presumptively. From the mixed effects logistic regression model, the predictors of presumptive treatment of uncomplicated malaria were case management training (AOR = 0.44; 95% CI = (0.18 – 1.09)), asked signs or symptoms (AOR = 0.19; 95% CI = (0.10 - 0.37)) and results presented (AOR = 0.08 95% CI = (0.03 - 0.19)). Conclusions: Presumptive treatment of uncomplicated malaria remains a challenge in the private retail sector. Malaria case management training and health care providers asking of signs and symptoms and results presented predicts presumptive treatment. To address the issue of presumptive treatment of Malaria, strengthening of malaria case management training is key for health care providers in the private sector.
Freestanding metal nanohole array for high-performance applications
Authors: Du Bobo , Ruan Yinlan , Yang Dexing , Jia Peipei , Gao Shoufei , Wang Yingying , Wang Pu , Ebendorff-Heidepriem Heike 
Published: August 2020

Plasmonic devices using periodic metallic nanostructures have recently gained tremendous interest for color filters, sensing, surface enhanced spectroscopy, and enhanced photoluminescence, etc. However, the performance of such plasmonic devices is severely hampered by the solid substrates supporting the metallic nanostructures. Here, a strategy for freestanding metallic nanomembranes is introduced by taking advantages of hollow substrate structures. Large-area and highly uniform gold nanomembranes with nanohole array are fabricated via a flexible and simple replication-releasing method. The hollow structures include a hollow core fiber with 30 μm core diameter and two ferrules with their hole diameter as 125 and 500 μm, respectively. As a proof-of-concept demonstration, 2 times higher sensitivity of the bulk refractive index is obtained with this platform compared to that of a counterpart on a solid silica substrate. Such a portable and compact configuration provides unique opportunities to explore the intrinsic properties of the metal nanomembranes and paves a new way to fabricate high-performance plasmonic devices for biomolecule sensing and color filter.
Reduced levels of circulating natural killer cells in children with celiac disease
Authors: Agin Mehmet , Sevinc Eylem , Dogan Erkan , Sevinc Nergiz 
Published: August 2020

Background Celiac disease (CD) is an autoimmune disease characterized by malabsorption. Serologic testing for CD consists of Ig A type of antitissue transglutaminase (tTG), antiendomysium (EMA). These tests are helpful in monitoring adherence to the gluten-free diet (GFD). Natural killer (NK) cell count alterations have been reported in various diseases, such as cancer, Crohn’s disease, malnutrition, and autoimmune disorders.
Objective To compare peripheral blood NK cell counts in children with celiac disease (CD) to healthy controls. The second aim was to analyze for possible correlations between NK cells (CD3-/CD16+, CD56+) and tissue transglutaminase (tTG)-IgA and tTG-IgG, as well as endomysial antibody EMA-IgA indicating gluten sensitivity.
Methods Fifty children with CD were compared to 48 healthy children as controls, with similar age and sex distribution. Peripheral blood NK cell counts were measured by flow cytometry.
Results The median (P25-P75) ages of the 50 celiac patients (23 male; 46%) and 48 controls (21 male; 44%) were 10 (2-17) years and 9 (3-17) years, respectively. Mean follow-up duration was 3 years, ranging from 1-10 years. All CD patients had positive tTG-IgA and EMA-IgA tests while it was negative in all (100 %) control patients. The absolute number of circulating CD16+ NK cells (259.52 vs. 1404.36 μ/L) and CD56+ NK cells (366.24 vs. 2440.46 μ/L) were significantly lower in the celiac group than the control group (P<0.05 for both). The absolute numbers of circulating white blood cells (7785 vs. 8165 μ/L) and lymphocytes (3106 vs. 3173 μ/L) were not significantly different between the celiac and control groups (P>0.05 for both). Correlation analysis between the absolute number of circulating NK cells and tTG-IgA, tTG-IgG, and EMA-IgA levels in CD patients revealed no significant relationships (P>0.05 for all).
Conclusions Peripheral blood NK cell count were significantly lower in celiac patients than controls, hence, decreased NK cell counts may be an abnormal feature seen in autoimmune diseases. NK cell count in celiac patients had no significant correlations to tTG-IgA, tTG-IgG, or EMA-IgA levels. Therefore, NK cell count may be inappropriate marker for monitoring compliance to a gluten free diet.
Ouvrier’s Modified Mini Mental State Examination as a screening test for cognitive impairment in school-aged children with epilepsy
Authors: Saputra Hariadi Edi , Handryastuti Setyo , Mangunatmadja Irawan , Widodo Dwi Putro , Pardede Sudung O. 
Published: August 2020

Background Epilepsy may affect children's development, including their cognitive function. The prevalence of cognitive impairment in epilepsy patients is quite high. Weschler Intelligence Scale for Children (WISC) takes a long time to administer and is expensive, so a simpler screening tool for cognitive evaluation is needed in pediatric epilepsy patients.
Objective To assess the diagnostic value of Ouvrier’s Modified Mini Mental State Examination (MMSE) for detecting cognitive impairment in children aged 8-11 years with epilepsy.
Methods This diagnostic study was conducted in December 2018 to February 2019 at Cipto Mangunkusumo and Fatmawati Hospitals in Jakarta. Data were collected with purposive sampling of children with epilepsy aged 8 to 11 years. Cognitive function was assessed by Ouvrier’s Modified MMSE and WISC. Ouvrier’s Modified MMSE was compared to WISC as and the gold standard. Results were analyzed using a 2x2 table.
Results The prevalence of cognitive impairment in 8-11-year-old epilepsy patients was 72.9%. Ouvrier’s Modified MMSE had 83% sensitivity, 85% specificity, 94% positive predictive value, 65% negative predictive value, and 83% accuracy.
Conclusions Ouvrier’s Modified MMSE has good diagnostic value, thus it may be useful for early detection of cognitive impairment in pediatric epilepsy.
Impact of albumin levels on clinical outcomes in children underwent abdominal surgery
Authors: Dewi Rismala , Silitonga Freddy Guntur Mangapul , Mangunatmadja Irawan 
Published: August 2020

Background Patients underwent abdominal surgery and had hypoalbuminemia were at risk of post-operative complications. The prognostic role of albumin levels in children with abdominal surgery remains unclear.
Objective To investigate the impact of albumin levels on clinical outcomes related to the complications in children with abdominal surgery.
Methods This was a retrospective cohort study on children aged 29 days to 18 years, who underwent abdominal surgery, had serum albumin levels measured at pre-operative and within 48 hours post-operatively, and hospitalized in Paediatric Intensive Care Unit of Dr. Cipto Mangunkusumo Hospital, Indonesia. The primary outcomes were post-operative complications (sepsis, surgical site infection, shock), length of stay in PICU, dehiscence, relaparotomy, and postoperative mortality.
Results This study recruited a total of 201 children. Pre- and post-operative serum albumin levels of ≤ 3.00 g/dL were found in 15.4% and 51.2%, respectively. Pre- and post-operative serum albumin levels of ≤ 3.00 g/dL were associated with higher risk of post-operative sepsis (RR 3.4; 95%CI 1.54 to 7.51) and relaparotomy (RR 3.84; 95%CI 1.28 to 1.49). The median of length of PICU stay was 4 days longer in children with pre-operative serum albumin levels ≤ 3.00 g/dL (P<0.001).
Conclusions Hypoalbuminemia condition in children undergo abdominal surgery is associated with increased risk of post-operative sepsis, longer length of stay in PICU, and risk of relaparotomy.
On the growth analysis of meromorphic solutions of finite ϕ-order of linear difference equations
Authors: Datta Sanjib Kumar , Biswas Nityagopal 
Published: August 2020

Abstract
In this paper, we investigate some growth properties of meromorphic
solutions of higher-order linear difference equation

A
n

⁢

(
z
)

⁢
f
⁢

(

z
+
n

)

+
…
+

A
1

⁢

(
z
)

⁢
f
⁢

(

z
+
1

)

+

A
0

⁢

(
z
)

⁢
f
⁢

(
z
)

=
0

,

A_{n}(z)f(z+n)+\dots+A_{1}(z)f(z+1)+A_{0}(z)f(z)=0,

where

A
n

⁢

(
z
)

,
…
,

A
0

⁢

(
z
)

{A_{n}(z),\dots,A_{0}(z)}

are meromorphic
coefficients of finite φ-order in the complex plane where φ
is a non-decreasing unbounded function. We extend some earlier results of
Latreuch and Belaidi [Z. Latreuch and B. Belaïdi,
Growth and oscillation of meromorphic solutions of linear difference equations,
Mat. Vesnik 66 2014, 2, 213–222].
Sea Raiders in the Amarna Letters?
Authors: Emanuel Jeffrey P. 
Published: August 2020

AbstractThe Amarna corpus contains several references to maritime conflict and related activities in the 14th century BCE, including blockades, the movement of troops, the capturing of ships at sea, and seaborne evacuation. While most of these are encountered in the context of conflicts between Levantine polities, there are clear references to what might on the one hand be called piracy, but on the other hand either acts of naval warfare or naval elements of a larger war effort, on both land and sea. This paper considers the martial maritime activities discussed in the Amarna letters, with particular emphasis on two uniquely controversial groups mentioned in this corpus in the context of maritime violence: the ‘ships of the men of the city of Arwad’ and the ‘miši-men.’ While the men of Arwad are identified with a polity on the Phoenician coast, they are referred to only by this collective term, even when mentioned in lists that otherwise contain only rulers. The miši, on the other hand, are not associated with any specific name or toponym. The purpose of this study is to identify just what can be determined about the roles and affiliations of these two groups in their Amarna context in this period.
Influences of advanced glycosylation end products on the inner blood–retinal barrier in a co-culture cell model in vitro
Authors: Yuan Chen , Mo Ya , Yang Jie , Zhang Mei , Xie Xuejun 
Published: August 2020

AbstractAdvanced glycosylation end products (AGEs) are harmful factors that can damage the inner blood–retinal barrier (iBRB). Rat retinal microvascular endothelial cells (RMECs) were isolated and cultured, and identified by anti-CD31 and von Willebrand factor polyclonal antibodies. Similarly, rat retinal Müller glial cells (RMGCs) were identified by H&E staining and with antibodies of glial fibrillary acidic protein and glutamine synthetase. The transepithelial electrical resistance (TEER) value was measured with a Millicell electrical resistance system to observe the leakage of the barrier. Transwell cell plates for co-culturing RMECs with RMGCs were used to construct an iBRB model, which was then tested with the addition of AGEs at final concentrations of 50 and 100 mg/L for 24, 48, and 72 h. AGEs in the in vitro iBRB model constructed by RMEC and RMGC co-culture led to the imbalance of the vascular endothelial growth factor (VEGF) and pigment epithelial derivative factor (PEDF), and the permeability of the RMEC layer increased because the TEER decreased in a dose- and time-dependent manner. AGEs increased VEGF but lowered PEDF in a dose- and time-dependent manner. The intervention with AGEs led to the change of the transendothelial resistance of the RMEC layer likely caused by the increased ratio of VEGF/PEDF.
Biocompatibility and corrosion resistance of metallic biomaterials
Authors: Ali Sadaqat , Abdul Rani Ahmad Majdi , Baig Zeeshan , Ahmed Syed Waqar , Hussain Ghulam , Subramaniam Krishnan , Hastuty Sri , Rao Tadamilla V.V.L.N. 
Published: August 2020

Abstract
Biomaterials play a significant role in revolutionizing human life in terms of implants and medical devices. These materials essentially need to be highly biocompatible and inert to the human physiological conditions. This paper provides an in-depth, critical and analytical review on the previous research work and studies conducted in the field of metals and alloys used as implant materials including stainless steel, titanium and its alloys, cobalt chromium and others. Since the manufacturing of medical implants relies on selected grades of biomaterials, metals play a significant role in biomaterials market. This paper focuses on highlighting some basic principles of manufacturing implant materials underlying composition, structure and properties of these materials. Finally, attention is also given to the role of these implant materials on the betterment of human life in terms of their failures by critically analysing these materials.
Agnathia-otocephaly complex: a case report and a literature review on recurrence risk
Authors: Vanhees Lievelijn , Denayer Ellen , Thaens Anke , Fransis Sabine , Van Hoestenberghe Marie-Rose 
Published: August 2020

Abstract

Objectives
Agnathia-otocephaly complex (AOC) is an extremely rare, lethal disorder causing obstruction of the upper airway at birth due to absence of the mandible and hypoplasia of the oral cavity. Implications for future pregnancies need to be elucidated by parental counselling, as recurrence of AOC or associated comorbidities are possible. Very little is known on this subject, because of the rarity of the disorder and scarce data on genetic causes of this complex. The objectives of this study were to determine the recurrence risk and mode of inheritance for AOC based on current literature.

Contents
Recurrence of AOC or associated comorbidities within the family of an index case was reported in eight articles, describing 7 and 27 relatives, respectively. There were eight AOC cases in which the genetic cause was known. Mutations in 2 genes, orthodenticle homeobox 2 (OTX2) and paired related homeobox 1 (PRRX1), have been described. Due to its mainly sporadic appearance, recurrence risk is low. Counselling on recurrence risk is difficult, because of a broad heterogeneity with complex inheritance patterns and variability in phenotypic expression.

Outlook
Chromosomal analysis and exome sequencing in children with AOC will help unravel current aetiological uncertainties and could help in further reproductive decisions. We emphasize the need for timely diagnosis through ultrasound, providing parents with the opportunity to receive multidisciplinary counselling, giving them the chance to contemplate their management decisions.
Ein Bett gestalten
Authors: Dorschel Andreas 
Published: August 2020

Abstract
In the process of making bedsteads, Plato claimed, makers look towards the ‘idea’ of the bed. But what is that idea? Two candidates come to mind: shape and purpose. The fact that we identify objects of very different shape, not even involving a bedstead, as beds seems to render purpose conceptually superior. But, then, what is a bed’s purpose? An obvious response appears tobe: lying down and sleeping. Yet, first, beds are not needed for that. Secondly, precisely when a bed is slept on, it is not perceived as a design object. Thirdly, beds constitute a kind of existential furniture, associated with giving birth, making love, suffering illness and dying. All such issues humans really care about, however, are strikingly indifferent towards the design of beds. As elsewhere, the maxim that form follows function fails. Design thinking might rather make headway when beds are conceived of as peculiar spaces within spaces.
Wesensform und Funktionswert
Authors: Schweppenhäuser Gerhard 
Published: August 2020

Abstract
The essay begins with some historical considerations on design, philosophy and science. The subsequent reflections focus on the quasi-metaphysical prerequisites of the conditions under which design objects and design processes are produced and received. It is a question of the relationships that can be reconstructed – in the context of nature’s subjugation, work, and social interaction – between purposes of use and external and internal determination of form. Under the social conditions of the capitalist economy, design casts things, nature and people into commodity form. This makes it possible to communicate them and to communicate with them. And by doing this in an aesthetic way, design produces at the same time images or representations of things, nature and people beyond their commodity form. In the sphere of the aesthetic appearance of objects and processes, their functionalisation is exceeded. The aesthetic paradigm shift from the primacy of the form of the design object to the primacy of the social function of aesthetic practice – introduced by Walter Benjamin’s media aesthetics – is actualised in a contradictory fashion in contemporary high-tech communication.