bluuebunny/crossref_metadata_2025_split huggingface dataset:
Precision and consistency of astrocombs
Authors: Milaković Dinko , Pasquini Luca , Webb John K , Lo Curto Gaspare 
Published: February 2020

ABSTRACT
Astrocombs are ideal spectrograph calibrators whose limiting precision can be derived using a second, independent, astrocomb system. We therefore analyse data from two astrocombs (one 18 GHz and one 25 GHz) used simultaneously on the HARPS (High Accuracy Radial velocity Planet Searcher) spectrograph at the European Southern Observatory. The first aim of this paper is to quantify the wavelength repeatability achieved by a particular astrocomb. The second aim is to measure wavelength calibration consistency between independent astrocombs, that is to place limits or measure any possible zero-point offsets. We present three main findings, each with important implications for exoplanet detection, varying fundamental constant and redshift drift measurements. First, wavelength calibration procedures are important: using multiple segmented polynomials within one echelle order results in significantly better wavelength calibration compared to using a single higher order polynomial. Segmented polynomials should be used in all applications aimed at precise spectral line position measurements. Secondly, we found that changing astrocombs causes significant zero-point offsets (${\approx}60\, {\rm cm\, s}^{-1}$ in our raw data) which were removed. Thirdly, astrocombs achieve a precision of ${\lesssim }4\, {\rm cm\, s}^{-1}$ in a single exposure (${\approx }10{{\,\rm per\,cent}}$ above the measured photon-limited precision) and 1 cm s−1 when time-averaged over a few hours, confirming previous results. Astrocombs therefore provide the technological requirements necessary for detecting Earth–Sun analogues, measuring variations of fundamental constants and the redshift drift.
The nearby spiral density-wave structure of the Galaxy: line-of-sight velocities of the Gaia DR2 main-sequence A, F, G, and K stars
Authors: Griv Evgeny , Gedalin Michael , Shih I-Chun , Hou Li-Gang , Jiang Ing-Guey 
Published: February 2020

ABSTRACT
Distances and velocities of $\approx \!2400\, 000$ main-sequence A, F, G, and K stars are collected from the second data release of ESA's Gaia astrometric mission. This material is analysed to find evidence of radial and azimuthal systematic non-circular motions of stars in the solar neighbourhood on the assumption that the system is subject to spiral density waves (those produced by a spontaneous disturbance, a central bar, or an external companion), developing in the Galactic disc. Data analysis of line-of-sight velocities of $\approx \!1500\, 000$ stars selected within 2 kpc from the Sun and 500 pc from the Galactic mid-plane with distance accuracies of &lt;10 per cent makes evident that a radial wavelength of the wave pattern is 1.1–1.6 kpc and a phase of the wave at the Sun’s location in the Galaxy is 55°–95°. Respectively, the Sun is situated at the inner edge of the nearest Orion spiral arm segment. Thus, the local Orion arm is a part of a predominant density-wave structure of the system. The spiral structure of the Galaxy has an oscillating nature corresponding to a concept of the Lin–Shu-type moderately growing in amplitude, tightly wound, and rigidly rotating density waves.
Electromagnetic signals from the decay of free neutrons in the first hours of neutron star mergers
Authors: Gottlieb Ore , Loeb Abraham 
Published: February 2020

ABSTRACT
The first hours following a neutron star merger are considered to provide several ultraviolet (UV)/optical/near-infrared signals: β-decay emission from free neutrons, radioactive decay of shocked heavy elements in the cocoon and cocoon’s cooling emission. Here, we consider two additional emission sources: β-decay of free neutrons in the cocoon and synchrotron by the β-decay electrons. We present three-dimensional relativistic hydrodynamic simulations of jets that propagate in a multi-layer ejecta from the merger and calculate semi-analytically the resulting light curves. We find that the free neutrons emission at high latitudes is enhanced by the cocoon by a factor of a few to power a wide (≲60°) and brief (∼1 h) UV signal that can reach an absolute magnitude of ≳−15, comparable with the cooling emission. If the ejected neutron matter mass is $M_{\rm n} \gtrsim 10^{-4}\, {\rm M_{\odot }}$, the synchrotron emission may yield a long (∼8 h) quasi-isotropic UV/optical signal with an absolute magnitude between −12 and −15, depending on the magnetic field. Such a high mass of a mildly relativistic component may partly obscure the cocoon’s shocked r-process elements, thereby attenuating its radioactive decay emission. Future observations on these time-scales, including null detections, may place constraints on the ejected neutron matter mass and shed light on the ejecta and jet-cocoon characteristics.
Extreme and high synchrotron peak blazars beyond 4FGL: The 2BIGB γ-ray catalogue
Authors: Arsioli B , Chang Y-L , Musiimenta B 
Published: February 2020

ABSTRACT
This paper presents the results of a γ-ray likelihood analysis over all the extreme and high synchrotron peak blazars (EHSP and HSP) from the 3HSP catalogue. We investigate 2013 multifrequency positions under the eyes of Fermi Large Area Telescope, considering 11 yr of observations in the energy range between 500 MeV and 500 GeV, which results in 1160 γ-ray signatures detected down to the TS=9 threshold. The detections include 235 additional sources concerning the Fermi Large Area Telescope Fourth Source Catalog (4FGL), all confirmed via high-energy TS (Test Statistic) maps, and represent an improvement of ∼25 per cent for the number of EHSP and HSP currently described in γ-rays. We build the γ-ray spectral energy distribution (SED) for all the 1160 2BIGB sources, plot the corresponding γ-ray logN−logS, and measure their total contribution to the extragalactic gamma-ray background, which reaches up to ∼33 per cent at 100 GeV. Also, we show that the γ-ray detectability improves according to the synchrotron peak flux as represented by the figure of merit parameter, and note that the search for TeV peaked blazars may benefit from considering HSP and EHSP as a whole, instead of EHSPs only. The 2BIGB acronym stands for ‘Second Brazil-ICRANet Gamma-ray Blazars’ catalogue, and all the broad-band models and SED data points will be available on public data repositories (OpenUniverse, GitHub, and Brazilian Science Data Center-BSDC).
Mycobacterial DNA polymerase I: activities and crystal structures of the POL domain as apoenzyme and in complex with a DNA primer-template and of the full-length FEN/EXO–POL enzyme
Authors: Ghosh Shreya , Goldgur Yehuda , Shuman Stewart 
Published: February 2020

Abstract
Mycobacterial Pol1 is a bifunctional enzyme composed of an N-terminal DNA flap endonuclease/5′ exonuclease domain (FEN/EXO) and a C-terminal DNA polymerase domain (POL). Here we document additional functions of Pol1: FEN activity on the flap RNA strand of an RNA:DNA hybrid and reverse transcriptase activity on a DNA-primed RNA template. We report crystal structures of the POL domain, as apoenzyme and as ternary complex with 3′-dideoxy-terminated DNA primer-template and dNTP. The thumb, palm, and fingers subdomains of POL form an extensive interface with the primer-template and the triphosphate of the incoming dNTP. Progression from an open conformation of the apoenzyme to a nearly closed conformation of the ternary complex entails a disordered-to-ordered transition of several segments of the thumb and fingers modules and an inward motion of the fingers subdomain—especially the O helix—to engage the primer-template and dNTP triphosphate. Distinctive structural features of mycobacterial Pol1 POL include a manganese binding site in the vestigial 3′ exonuclease subdomain and a non-catalytic water-bridged magnesium complex at the protein-DNA interface. We report a crystal structure of the bifunctional FEN/EXO–POL apoenzyme that reveals the positions of two active site metals in the FEN/EXO domain.
Broadly applicable oligonucleotide mass spectrometry for the analysis of RNA writers and erasers in vitro
Authors: Hagelskamp Felix , Borland Kayla , Ramos Jillian , Hendrick Alan G , Fu Dragony , Kellner Stefanie 
Published: February 2020

Abstract
RNAs are post-transcriptionally modified by dedicated writer or eraser enzymes that add or remove specific modifications, respectively. Mass spectrometry (MS) of RNA is a useful tool to study the modification state of an oligonucleotide (ON) in a sensitive manner. Here, we developed an ion-pairing reagent free chromatography for positive ion detection of ONs by low- and high-resolution MS, which does not interfere with other types of small compound analyses done on the same instrument. We apply ON-MS to determine the ONs from an RNase T1 digest of in vitro transcribed tRNA, which are purified after ribozyme-fusion transcription by automated size exclusion chromatography. The thus produced tRNAValAAC is substrate of the human tRNA ADAT2/3 enzyme and we confirm the deamination of adenosine to inosine and the formation of tRNAValIACin vitro by ON-MS. Furthermore, low resolution ON-MS is used to monitor the demethylation of ONs containing 1-methyladenosine by bacterial AlkB in vitro. The power of high-resolution ON-MS is demonstrated by the detection and mapping of modified ONs from native total tRNA digested with RNase T1. Overall, we present an oligonucleotide MS method which is broadly applicable to monitor in vitro RNA (de-)modification processes and native RNA.
Dialysis after graft loss: a Swiss experience
Authors: Bonani Marco , Achermann Rita , Seeger Harald , Scharfe Michael , Müller Thomas , Schaub Stefan , Binet Isabelle , Huynh-Do Uyen , Dahdal Suzan , Golshayan Dela , Hadaya Karine , Wüthrich Rudolf P , Fehr Thomas , Segerer Stephan 
Published: February 2020

AbstractBackgroundPatients returning to dialysis after graft loss have high early morbidity and mortality.MethodsWe used data from the Swiss Transplant Cohort Study to describe the current practice and outcomes in Switzerland. All patients who received a renal allograft between May 2008 and December 2014 were included. The patients with graft loss were divided into two groups depending on whether the graft loss occurred within 1 year after transplantation (early graft loss group) or later (late graft loss group). Patients with primary non-function who never gained graft function were excluded.ResultsSeventy-seven out of 1502 patients lost their graft during follow-up, 40 within 1 year after transplantation. Eleven patients died within 30 days after allograft loss. Patient survival was 86, 81 and 74% at 30, 90 and 365 days after graft loss, respectively. About 92% started haemodialysis, 62% with definitive vascular access, which was associated with decreased mortality (hazard ratio = 0.28). At the time of graft loss, most patients were on triple immunosuppressive therapy with significant reduction after nephrectomy. One year after graft loss, 77.5% (31 of 40) of patients in the early and 43.2% (16 out of 37) in the late-loss group had undergone nephrectomy. Three years after graft loss, 36% of the patients with early and 12% with late graft loss received another allograft.ConclusionIn summary, our data illustrate high mortality, and a high number of allograft nephrectomies and re-transplantations. Patients commencing haemodialysis with a catheter had significantly higher mortality than patients with definitive access. The role of immunosuppression reduction and allograft nephrectomy as interdependent factors for mortality and re-transplantation needs further evaluation.
Contract Negotiation for Neurosurgeons: A Practical Guide
Authors: Menger Richard , Esfahani Darian R , Heary Robert , Ziu Mateo , Mazzola Catharine A , LeFever Devon , Origitano Thomas , Barnes Todd , Cozzens Jeffrey , Taylor Sherry 
Published: February 2020

Abstract
Contract negotiation is a reality in the career of any neurosurgeon. However, little formal training exists for physicians – including neurosurgeons – on potential techniques and strategies for conducting meaningful contract negotiation. Increasing numbers of neurosurgeons seek hospital employment for which an employment contract will be provided. During contract negotiation, it is likely that a young neurosurgeon will be in discussion with an experienced negotiator acting on behalf of a hospital, practice, or department. Understanding and adapting to this imbalance in experience and using basic negotiating techniques as a means of approaching and resolving key contract issues is critical for the neurosurgeon to maximize his or her value in the course of contract negotiation. Even without formal training in negotiation in residency, negotiation skills can be taught, practiced, and improved. In affiliation with the Medical Director's Ad-Hoc Representational Section of Council of State Neurosurgical Societies (CSNS) this article is intended to serve as a practical guide for contract negotiation. Contract basics, negotiation terms, strategies, unique neurosurgical issues, and value creation are explored.
Predictability of real temporal networks
Authors: Tang Disheng , Du Wenbo , Shekhtman Louis , Wang Yijie , Havlin Shlomo , Cao Xianbin , Yan Gang 
Published: February 2020

Abstract
Links in most real networks often change over time. Such temporality of links encodes the ordering and causality of interactions between nodes and has a profound effect on network dynamics and function. Empirical evidence has shown that the temporal nature of links in many real-world networks is not random. Nonetheless, it is challenging to predict temporal link patterns while considering the entanglement between topological and temporal link patterns. Here, we propose an entropy-rate-based framework, based on combined topological–temporal regularities, for quantifying the predictability of any temporal network. We apply our framework on various model networks, demonstrating that it indeed captures the intrinsic topological–temporal regularities whereas previous methods considered only temporal aspects. We also apply our framework on 18 real networks of different types and determine their predictability. Interestingly, we find that, for most real temporal networks, despite the greater complexity of predictability brought by the increase in dimension, the combined topological–temporal predictability is higher than the temporal predictability. Our results demonstrate the necessity for incorporating both temporal and topological aspects of networks in order to improve predictions of dynamical processes.
Dual Burden of Smoked and Smokeless Tobacco Use in India, 2009–2017: A Repeated Cross-Sectional Analysis Based on Global Adult Tobacco Survey
Authors: Singh Prashant Kumar , Yadav Amit , Lal Pranay , Sinha Dhirendra N , Gupta Prakash C , Swasticharan Leimapokpam , Singh Shalini , Mehrotra Ravi 
Published: February 2020

Abstract

Introduction
The dual use of smoked and smokeless tobacco (SLT) poses a serious challenge to tobacco control efforts. This article examines the trends and patterns of this usage in India during the period 2009–2010 and 2016–2017.

Methods
Data from two rounds of nationally representative cross-sectional Global Adult Tobacco Survey (GATS) conducted in 2009–2010 and 2016–2017 have been used. Dual use was assessed based on current smokers and SLT users in both rounds.

Results
Findings reveal that dual use in India has dropped from 5.3% during 2009–2010 to 3.4% during 2016–2017, a decline of nearly 10 million dual users. However, some states have added nearly 4.6 million new dual users during this period. While dual use continues to remain high in rural areas, there has been a manifold increase in urban areas. Findings revealed that intention to quit tobacco was lower among dual tobacco users as compared to single users with considerable difference between urban and rural areas.

Conclusion
Easy availability and affordability of SLT products compared to smoking products and restrictions on smoking in public places may have pushed current smokers and dual users to take to or intensify their SLT consumption. Measures relating to awareness, pricing, taxation, and enforcement of tobacco control laws should focus on all forms of tobacco, especially targeting high dual burden in rural and urban settings.

Implications
Dual form of tobacco users represent 12% of all tobacco users in the country. The study reveals that intention to quit tobacco among dual users is significantly lower than that among single tobacco product users. This requires improving public awareness about the morbidity and mortality that arises from the use of all forms of tobacco products. Efforts to restrict the availability of tobacco products should focus on licensing the sale of all tobacco products. Reduction in dual tobacco use will not only result in multiplied health benefits but also help in achieving the Non-Communicable Diseases targets under the United Nations Sustainable Development Goals.
Applying focused ethnographic methods: examining implications of intracultural diversity for nutrition interventions
Authors: Pelto Gretel H 
Published: February 2020

Abstract
This paper examines the implications of intracultural difference for the design and implementation of nutrition interventions. It raises the question of whether small-sample, mixed-method implementation research, using a focused ethnographic approach, has sufficient power to detect meaningful differences in cultural beliefs, values, perceptions, and attitudes that are important for the design and implementation of nutrition interventions. It first presents the theoretical framework that was used to guide the research, followed by a description of the methodology of the Focused Ethnographic Study for Infant and Young Child Feeding. It then uses the findings from recent research in Ghana to address the central question. The findings document strong elements of shared cultural consensus, but intracultural differences of importance, in relation to the planning and content of behavior change communication.
New constraints on the mass bias of galaxy clusters from the power spectra of the thermal Sunyaev–Zeldovich effect and cosmic shear
Authors: Makiya Ryu , Hikage Chiaki , Komatsu Eiichiro 
Published: February 2020

AbstractThe thermal Sunyaev–Zeldovich (tSZ) power spectrum is a powerful probe of the present-day amplitude of matter density fluctuations, and has been measured up to $\ell \approx 10^3$ from the Planck data. The largest systematic uncertainty in the interpretation of this data is the so-called “mass bias” parameter B, which relates the true halo mass to the mass proxy used by the Planck team as $M\,_{\rm 500c}^{\rm Planck}=M\,_{\rm 500c}^{\rm true}/B$. Since the power spectrum of the cosmic weak lensing shear is also sensitive to the amplitude of matter density fluctuations via $S_8\equiv \sigma _8 \Omega _{\rm m}^{\alpha }$ with $\alpha \sim 0.5$, we can break the degeneracy between the mass bias and the cosmological parameters by combining the tSZ and cosmic shear power spectra. In this paper, we perform a joint likelihood analysis of the tSZ power spectrum from Planck and the cosmic shear power spectrum from Subaru Hyper Suprime-Cam. Our analysis does not use the primordial cosmic microwave background (CMB) information. We obtain a new constraint on the mass bias as $B = 1.37 ^{+0.15}_{-0.23}$ or $(1-b) = B^{-1}=0.73^{+0.08}_{-0.13}$ ($68\%$ confidence limit), for $\sigma _8 &lt; 0.9$. This value of B is lower than that needed to reconcile the tSZ data with the primordial CMB and CMB lensing data, i.e., $B = 1.64 \pm 0.19$, but is consistent with the mass bias expected from hydrodynamical simulations, $B = 1.28 \pm 0.20$. Thus our results indicate that the mass bias is consistent with the non-thermal pressure support from mass accretion of galaxy clusters via the cosmic structure formation, and that the cosmologies inferred from the tSZ and the cosmic shear are consistent with each other.
Beta-lactam allergy in the paediatric population
Authors: Wong Tiffany , Atkinson Adelle , t’Jong Geert , Rieder Michael J , Chan Edmond S , Abrams Elissa M 
Published: February 2020

Abstract
Beta-lactam allergy is commonly diagnosed in paediatric patients, but over 90% of individuals reporting this allergy are able to tolerate the medications prescribed after evaluation by an allergist. Beta-lactam allergy labels are associated with negative clinical and administrative outcomes, including use of less desirable alternative antibiotics, longer hospitalizations, increasing antibiotic-resistant infections, and greater medical costs. Also, children with true IgE-mediated allergy to penicillin medications are often advised to avoid all beta-lactam antibiotics, including cephalosporins, which is likely unnecessary in greater than 97% of those reporting penicillin allergies. Most patients can be safely treated with penicillin or amoxicillin if they do not have a history compatible with IgE-mediated or systemic, delayed reactions such as Stevens-Johnson syndrome (SJS), serum sickness-like reactions, drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, or acute generalized exanthematous pustulosis (AGEP). Guidance is provided on how to stratify risk of beta-lactam allergy, and on test dosing and monitoring in the outpatient setting for patients deemed low risk. Guidance for patients at higher risk of beta-lactam allergy includes criteria for appropriate referral to allergists and the use of alternative antimicrobials, such as cephalosporins, while awaiting specialist assessment.
L’allergie aux bêta-lactamines dans la population pédiatrique
Authors: Wong Tiffany , Atkinson Adelle , t’Jong Geert , Rieder Michael J , Chan Edmond S , Abrams Elissa M 
Published: February 2020

Abstract
L’allergie aux bêta-lactamines est souvent diagnostiquée chez les patients pédiatriques, mais plus de 90 % de ceux qui déclarent en être victimes peuvent tolérer les médicaments prescrits après avoir été évalués par un allergologue. Une « étiquette » d’allergie aux bêta-lactamines est liée à des résultats cliniques et administratifs négatifs, y compris l’utilisation d’autres antibiotiques moins indiqués, des hospitalisations plus longues, une augmentation des infections antibiorésistantes et des coûts médicaux plus élevés. De plus, pour les enfants ayant une véritable allergie à médiation IgE aux pénicillines, on conseille souvent d’éviter toutes les bêta-lactamines, y compris les céphalosporines, ce qui n’est probablement pas nécessaire chez plus de 97 % de ceux qui déclarent être allergiques à la pénicilline. La plupart des patients peuvent recevoir un traitement à la pénicilline ou à l’amoxicilline en toute sécurité s’ils n’ont pas d’antécédents compatibles avec des réactions à médiation IgE ni avec des réactions systémiques tardives comme le syndrome de Stevens-Johnson, une réaction de type maladie sérique, le syndrome d’éruption médicamenteuse avec éosinophilie et manifestations systémiques ou la pustulose exanthématique aiguë généralisée. Des directives sont proposées pour stratifier le risque d’allergie aux bêta-lactamines ainsi que pour administrer des doses tests aux patients considérés comme à faible risque et les surveiller en milieu ambulatoire. Les directives sur les patients à plus haut risque d’allergie aux bêta-lactamines comprennent les critères pour les diriger vers des allergologues et l’utilisation d’autres antimicrobiens tels que les céphalosporines, en attendant l’évaluation par un spécialiste.