bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of abdominal compression device on patients after external hernia repair surgery: A systematic review and meta-analysis
Authors: Xiong Binru , Liu Shi 
Published: February 2025

Background:
To evaluate the effectiveness of abdominal compression devices after external hernia repair.

Methods:
A search was conducted for randomized controlled trials on the application of abdominal compression devices after abdominal hernia repair surgery in databases such as Cochrane Library, PubMed, EMbase, CNKI, VIP, and Wanfang Data Knowledge Service Platform. The retrieval deadline was from the establishment of the database to November 2024. Two researchers independently assessed the risk of bias of the included studies and extracted relevant data using pre designed tables. RevMan 5.4 software was used for statistical analysis.

Results:
Ten articles were included, with a total of 1081 patients undergoing abdominal hernia repair surgery. The systematic review and meta-analysis results showed no statistically significant difference in the incidence of wound infection (relative risk [RR] = 0.41, P > .05), wound bleeding (RR = 0.56, P > .05), perineal hematoma (RR = 0.93, P > .05), or wound infection (RR = 0.40, P > .05). In terms of pain, subgroup analysis was performed to determine the incidence of wound infection (RR = 0.41), wound bleeding (RR = 0.56, P > .05), perineal hematoma (RR = 0.93, P > .05), and recurrence (RR = 0.70, P > .05) between the compression group and non-compression group. In terms of pain, subgroup analysis showed that the postoperative use of abdominal bands to compress the surgical area could reduce pain (mean difference [MD] = −1.17, P < .01), while the use of sandbags was not recommended, while the use of sandbags to compress the surgical area increased pain (MD = 1.09, P < .01).

Conclusion:
After abdominal hernia repair surgery, the use of abdominal compression devices had no significant effect on reducing the incidence of serum swelling, wound infection, and recurrence compared to the method of removing compression. After abdominal hernia repair surgery, the use of abdominal compression devices had no significant effect on reducing the incidence of serum swelling, wound infection, and recurrence compared to the method of removing compression. Abdominal band compression has a significant effect on reducing pain, whereas sandbag compression can increase pain.
Journals with “pain” in their titles: A web of science-based bibliometric analysis
Authors: Chi Shao-Yu , Wu Wei-Ting , Chang Ke-Vin , Özçakar Levent 
Published: February 2025

Background:
Pain, a critical symptom prevalent in various diseases and syndromes, has garnered increased attention in recent scientific literature. Bibliometric analyses can offer valuable multi-disciplinary insights into pain. This bibliometric analysis focused on journals with “pain” in their titles.

Methods:
Using the Master Journal List in the Web of Science (WoS) database (up to December 31, 2024), we searched all the journals indexed in Science Citation Index Expanded (SCIE) or Social Sciences Citation Index (SSCI) with “pain” in their titles. For further analyses, we extracted data about the journals including publisher, country, language, frequency, SCIE/SSCI categories, journal impact factor, and citation.

Results:
We identified 19 journals with “pain” in their titles. All the included journals were indexed in SCIE, with Pain Management Nursing also indexed in SSCI. More than half of the journals were published in the United States of America or the United Kingdom, and all were in English. Regarding the SCIE categories, 13 journals were listed in “clinical neurology,” 8 in “anesthesiology,” and 5 in “neurosciences.” From 2018 to 2022, either Pain or Journal of Headache and Pain maintained the highest impact factor. Furthermore, Pain held the record for the most citable articles and reviews and the most total citations in 2022.

Conclusion:
This study is the first bibliometric analysis of journals, rather than articles, in the field of pain. Pain is the most recognized journal in the field, with the highest number of citations and the highest average impact factor. In the future, bibliometric studies should explore other relevant journals without the word “pain” in their titles, in order to gain a more comprehensive understanding of the scientific literature on pain studies.
The ‘art’ of communication therapy
Authors: Dawson Camilla , Wheeler Jo 
Published: February 2025

Purpose of review
An overview of research exploring communication rehabilitation published between 2022 and 2024. There is limited research in the field so this timely review offers the clinician an insight into the available literature and the gaps that exist.

Recent findings
The review identified four main themes related to communication and speech rehabilitation; articulation and intelligibility, measures of function following surgical interventions, therapeutic interventions and their variability and quality of life outcomes.

Summary
Clinicians may benefit from identifying organizational, institutional, cultural, practical and data driven influences on their clinical interventions and capacity to provide person-centred communication rehabilitation. There is an ongoing need to move beyond measurement of compromise and impairment-based interventions, to explore how enhancing communicative competence using multiple rehabilitative interventions from the Speech and Language Therapist may improve holistic outcomes for people with head and neck cancer.
Drivers of Bronchodilator Use in Bronchiolitis
Authors: Rivera-Sepulveda Andrea , Maul Timothy , Jurlina Anna , Blake Kathryn V. , Davis Matthew M. , Alexander Kenneth 
Published: February 2025

Objectives:
This study aims to evaluate patient characteristics associated with bronchodilator (BD) use at various stages of bronchiolitis illness and evaluate corresponding patient outcomes in the emergency department (ED).

Methods:
This retrospective, cross-sectional study involves secondary data analysis from a sample of 932 children ages 3 to 24 months who received a diagnosis of bronchiolitis during an ED visit (1057 cases). Predictor variables included demographics, past medical history, family history, physical findings, medication use, and disposition. Outcomes included BD use for bronchiolitis symptoms in the pre-ED and ED settings, and associated care outcomes in the ED. Predictors of BD use in the ED with statistical significance were incorporated in a predictive multivariable logistic regression model with a training-validation split of 70% to 30%.

Results:
Children with prior BD use were significantly more likely than children without such history to receive BD treatment during their current bronchiolitis illness before the ED [odds ratio (OR): 23.7, 95% CI: 14.4-39], in the ED (OR: 2.6, 95% CI: 1.76-3.77), and as a prescription upon discharge from the ED (OR: 3.7, 95% CI: 2.49-5.58). In multivariable regression analyses, older age, parental asthma history, and wheezes and retractions on ED physical examination were significantly associated with BD use in the ED (P<0.05). The area under the curve for the validation model with these variables was 0.826 (95% CI: 0.794-0.858).

Conclusions:
Prior BD use was associated with subsequent use during the current illness, during ED care, and subsequent prescription, forming a cyclical pattern. A perceived bronchospastic phenotype of bronchiolitis may influence clinical practice in ED settings.
Thoracoabdominal Normothermic Regional Perfusion: Real-world Experience and Outcomes of DCD Liver Transplantation
Authors: Bababekov Yanik J. , Ha Anna H. , Nydam Trevor L. , Goncalves Carlos , Choudhury Rashikh , Shinsako JoLynn , Baimas-George Maria , Reynolds David M. , Yoshida Cassidy , Racke Caroline A. , Grewal Han , Pomposelli Sophia , Rodriguez Ivan E. , Hoffman Jordan R.H. , Schold Jesse D. , Kaplan Bruce , Pomfret Elizabeth A. , Pomposelli James J. 
Published: February 2025

Background.
Donation after circulatory death liver transplantation (DCD LT) is underused given historical outcomes fraught with ischemic cholangiopathy (IC). We aimed to assess 6-mo IC in LT from DCD via normothermic regional perfusion (NRP) compared with DCD via static cold storage (SCS).

Methods.
A retrospective review of adult Maastricht-III DCD liver donors and recipients at the University of Colorado Hospital from January 1, 2017, to August 27, 2024, was performed. The 6-mo IC rate was compared between NRP and SCS. Secondary outcomes included biochemical assessments of accepted versus declined NRP liver allografts and allograft and patient survival for NRP and SCS groups.

Results.
One hundred sixty-two DCD LTs (SCS = 79; NRP = 97) were performed and 150 recipients (SCS = 74; NRP = 86) reached 6-mo follow-up. Six-month IC was lower for NRP compared with SCS (1.2% versus 9.5%, P = 0.03). The Donor Risk Index (2.44 [2.02–2.82] versus 2.17 [1.97–2.30], P = 0.002) and UK DCD Risk Score (4.2 ± 2.9 versus 3.2 ± 2.3, P = 0.008) were higher for NRP versus SCS. The Liver Graft assessment Following Transplantation score was less for NRP compared with SCS (–3.3 versus –3.1, P < 0.05). There were several differences in median biochemical parameters during NRP between accepted and declined livers, including higher terminal biliary bicarbonate (22.7 [20.9–29.1] versus 10.8 [7.6–13.1] mEq/L, P = 0.004). There were no significant differences in 12-mo allograft or patient survival for NRP versus SCS.

Conclusions.
NRP is a disruptive innovation that improves the utilization of DCD livers. Despite higher-risk donor-recipient pairing for NRP compared with SCS, we demonstrate a decrease in IC for NRP. These data facilitate benchmarking of thoracoabdominal NRP DCD LT and support further protocol development.
Multi-omics dissection of Parkinson’s patients in subgroups associated with motor and cognitive severity
Authors: Athieniti Efi , Afxenti Sotiroula , Minadakis George , Spyrou George M. 
Published: February 2025

AbstractHeterogeneity in the severity of Parkinson’s disease (PD) inhibits the effective interpretation of clinical trial outcomes. Multi-omics analysis may help explain the pathological mechanisms underlying disease progression and reveal biomarkers of clinical severity. We performed Multi-Omics Factor Analysis (MOFA) on whole blood RNA, miRNA and Cerebrospinal fluid (CSF) and blood plasma proteomics from the Parkinson’s Progression Marker Initiative (PPMI), to identify molecular factors correlated with motor (MDS-UPDRS3) and cognitive (Semantic Fluency Test, SFT) function. Three molecular factors significantly correlated with the MDS-UPDRS3 score and two with SFT, which remained significant after adjusting for age, sex, and medication dose. We used the identified factors to stratify patients into subgroups with distinct motor and cognitive severity. The severe motor clusters showed deregulation of cytotoxic natural killer cell mechanisms in peripheral blood, and changes to proteins associated with the endoplasmic reticulum in CSF. The severe cognitive clusters showed changes in complement and synaptic dysfunction. Our analysis capitalizes on multi-omics data integration to enrich our understanding of the mechanisms driving motor and cognitive decline in PD, to support precision medicine.
“The injection gives freedom” - An exploration of long-acting injectable HIV treatment acceptance among patients seeking care in two Nairobi tertiary hospitals
Authors: Nyukuri Duncan , Shah Reena Chhotalal , Mbithi Annastacia , Abongo Melanie , Kundu Christine , Mutai Keneth 
Published: February 2025

Background Long-acting injectable antiretroviral therapy offers an alternative to daily oral HIV treatment, potentially improving adherence and reducing stigma. While its adoption has been successful in some settings, little is known about its acceptability among people living with HIV in Kenya. This study evaluates the acceptability, barriers, and facilitators of long-acting injectable antiretroviral therapy among people living with HIV in Nairobi, Kenya. Methods We conducted a mixed-methods study involving 356 people living with HIV receiving care at Kenyatta National Hospital and Aga Khan University Hospital. Quantitative data were collected through structured surveys, while qualitative insights were obtained from three focus group discussions. Descriptive and inferential statistical analyses were performed on survey data, and thematic analysis was applied to focus group discussions transcripts. Results Overall, 72.2% of participants expressed willingness to switch to long-acting injectable antiretroviral therapy Interest in long-acting injectable antiretroviral therapy was significantly associated with prior knowledge (93.9% vs 80.2%, p < 0.001) and more likely among women ((93.5% vs. 83.9%, p = 0.009). Key facilitators included the opportunity to stop taking daily pills (71.3%), improved adherence (50.3%) and reduced daily focus on HIV (44.7%). The most frequently cited barriers were fear of side effects (69.7%), needle phobia (32.3%), and distrust in new treatments (20.2%). focus group discussions revealed interest about long-acting injectable antiretroviral therapy’s potential to reduce stigma and improve adherence, but also concerns about side effects, access, and the need for robust support systems. Conclusion People living with HIV in the participating hospitals in Nairobi showed strong interest in long-acting injectable antiretroviral therapy, driven by its potential to improve adherence and reduce stigma. However, concerns about side effects, injections, and access must be addressed. Targeted education, provider training, and healthcare support are crucial for successful implementation.
Genetic Regulation of the Metabolome Differs by Sex, Alzheimer’s Disease Stage, and Plasma Biomarker Status
Authors: Eissman Jaclyn M. , Qiao Min , Kalia Vrinda , Zerlin-Esteves Marielba , Reyes-Dumeyer Dolly , Piriz Angel , Dubey Saurabh , Nandakumar Renu , Lee Annie J. , Lantigua Rafael A. , Medrano Martin , Mejia Diones Rivera , Honig Lawrence S. , Dalgard Clifton L. , Miller Gary W , Mayeux Richard , Vardarajan Badri N. 
Published: February 2025

AbstractWe investigated genetic regulators of circulating plasma metabolites to identify pathways underlying biochemical changes in clinical and biomarker-assisted diagnosis of Alzheimer’s disease (AD). We computed metabolite quantitative trait loci by using whole genome sequencing and small molecule plasma metabolites from 229 older adults with clinical AD and 322 age-matched healthy controls. Unbiased associations between 6,881 metabolites and 332,772 common genetic variants were tested, adjusted for age, sex, and both metabolomic and genomic principal components. We identified 72 novel and known SNP-metabolite associations spanning 66 genes and 12 metabolite classes, includingPYROXD2and N6-methyllysine,FAAHand myristoylglycine, as well asFADS2and arachidonic acid. In addition, we found differences in genetic regulation of metabolites among individuals with clinically defined AD compared to AD defined by a published plasma P-tau181 level cut-off. We also found more SNP-metabolite associations among males compared to females. In summary, we identified sex- and disease-specific genetic regulators of plasma metabolites and unique biological mechanisms of genetic perturbations in AD.
A Novel Method to Disentangle Tightly Linked Risk and Resilience Genes for Brain Disorders: Application to Alzheimer’s Disease
Authors: Barnett Eric J , Hess Jonathan L , Hou Jiahui , Escott-Price Valentina , Fennema-Notestine Christine , Kremen William , Lin Shu-Ju , Zhang Chunling , Gaiteri Chris , Elman Jeremy , Holmans Peter , Faraone Stephen V , Glatt Stephen J 
Published: February 2025

AbstractBackgroundGenetic risk factors for psychiatric and neurodegenerative disorders are well documented. However, some individuals with high genetic risk remain unaffected, and the mechanisms underlying such resilience remain poorly understood. The presence of protective resilience factors that mitigate risk could help explain the disconnect between predicted risk and reality, particularly for brain disorders, where genetic contributions are substantial but incompletely understood. Identifying and studying resilience factors could improve our understanding of pathology, enhance risk prediction, and inform preventive measures or treatment strategies. However, such efforts are complicated by the difficulty of identifying resilience that is separable from low risk.MethodsWe developed a novel adversarial multi-task neural network model to detect genetic resilience markers. The model learns to separate high-risk unaffected individuals from affected individuals at similar risk while “unlearning” patterns found in low-risk groups using adversarial learning. In simulated and existing Alzheimer’s disease (AD) datasets, we identified markers of resilience with a feature-importance-based approach that prioritized specificity, generated resilience scores, and analyzed associations with polygenic risk scores (PRS).ResultsIn simulations, our model had high specificity and moderate sensitivity in identifying resilience markers, outperforming traditional approaches. Applied to AD data, the model generated genetic resilience scores protective against AD and independent of PRS. We identified five resilience-associated SNPs, including known AD-associated variants, underscoring their potential involvement in risk/resilience interactions.ConclusionsOur methods of modeling and evaluation of feature-importance successfully identified resilience markers that were obscured in previous work. The high specificity of our model provides high confidence that these markers reflect resilience and not simply low risk. Our findings support the utility of resilience scores in modifying risk predictions, particularly for high-risk groups. Expanding this method could aid in understanding resilience mechanisms, potentially improving diagnosis, prevention, and treatment strategies for AD and other complex brain disorders.
Nutritional regulation of cellular quiescence depth and cell cycle re-entry in Vasa2+/Piwi1+ cells in a sea anemone
Authors: Pascual-Carreras Eudald , Garschall Kathrin , Steinmetz Patrick R.H. 
Published: February 2025

SummaryAnimals with lifelong growth adjust their growth rates to nutrient availability, yet the underlying cellular and molecular mechanisms remain poorly understood. Here, we studied how food supply and TOR signalling regulate the cell cycle in a multipotent, Vasa2-/Piwi1-expressing cell population in the sea anemoneNematostella vectensis. We discovered that starvation induces a reversible G1/G0cell cycle arrest in Vasa2+/Piwi1+ cells and that cell cycle re-entry upon refeeding is dependent on TOR signalling. In addition, the length of the refeeding stimulus after starvation determines the proportion of cells that re-enter S-phase. Remarkably, prolonged starvation delayed both refeeding-induced TOR signalling activation and S-phase re-entry. This strongly suggests thatNematostellaVasa2+/Piwi1+ cells undergo starvation-controlled quiescence deepening, previously described only in unicellular eukaryotes and mammalian cell culture. The nutritional control of quiescence and cell proliferation may thus be a fundamental, evolutionarily conserved strategy underlying the environmental regulation of indeterminate growth in animals.
A riot of blooms begins to dazzle the eye: cognitive behavior with multimodal discourse during usefulness judgments of health information
Authors: Chen Jing , Zhang Lu 
Published: February 2025

PurposeAs the two sides of the same coin, usefulness and usability have emerged as pivotal research themes in user experience field. This study compares cognitive effort and cognitive resource allocation strategy across documents varying perceived usefulness and then across documents with different objective usability (unimodal vs multimodal discourses).Design/methodology/approachA controlled user study of four identifying tasks related to public health epidemics was conducted to collect data, including document usefulness as perceived by participants, presentation modes of the document and gaze behaviors on each document.FindingsUsefulness and modality discourse impact cognitive effort and resource allocation strategy in health information search. In useless health documents, spatial encoding resource spending increased significantly with multimodal discourse, and a spatial browsing strategy with an evident exploratory feature was applied; while in useful documents, including low-useful and high-useful, both spatial and information encoding resource spending increased significantly with multimodal discourse, and an information processing strategy with an evident comprehensive feature was applied. Notably, multimodal discourse failed to enhance decision-making effectiveness. Furthermore, in useful documents, the interaction effect of the presentation mode of useful information and multimodal discourse on cognitive effort followed an inverted U-shape pattern.Originality/valueThis paper sheds new light on the interaction effect of usefulness and usability on cognitive effort and resource allocation strategy, highlighting its significance in cognitive effort detecting for multimodal discourse and improving effectiveness and efficacy of health information identification by optimizing information presentation mode design.
Organisational career growth and work engagement: a moderated mediated model
Authors: Okon Samuel Essien , Dakare Olamitunji , Akaighe Godbless Onoriode , Adebiyi Sulaimon Olanrewaju 
Published: February 2025

PurposeDrawing from the conservation of resources theory and organisational justice theory, this study examined the direct and indirect (via career resilience) effects of organisational career growth on work engagement. We further examined the boundary condition of procedure justice in the relationship between organisational career growth, career resilience and work engagement.Design/methodology/approachWe employed time-lagged data collected in three waves from 431 employees working in the public health sector. Hierarchical regression analysis and Hayes Process Macro were used to test the study hypotheses.FindingsThe findings revealed that organisational career growth has a significant positive direct and indirect influence on work engagement in the presence of career resilience. Also, the boundary condition of procedural justice was significant for employees who perceived procedural justice to be high as opposed to low.Practical implicationsOrganisational career growth has a positive influence on employee work engagement. Therefore, public health organisations need to prioritise employee career growth by creating an enabling environment that will help employees' career prospects and mitigate employees’ perception of low procedural justice.Originality/valueThe originality of this study is in empirically establishing career resilience as an underlying mechanism in the relationship between organisational career growth and work engagement while considering the interactive effect of procedural justice. Additionally, the originality of this paper is demonstrated by empirically establishing that a perceived high level of procedural justice helps healthcare employees improve their work engagement, thus deepening our understanding of work engagement amongst health professionals.