bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concomitant Marked Decline in Prevalence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Other Respiratory Viruses Among Symptomatic Patients Following Public Health Interventions in Australia: Data from St Vincent’s Hospital and Associated Screening Clinics, Sydney, NSW
Authors: Marriott Deborah , Beresford Rohan , Mirdad Feras , Stark Damien , Glanville Allan , Chapman Scott , Harkness Jock , Dore Gregory J , Andresen David , Matthews Gail V 
Published: August 2020

AbstractOur Australian hospital tested almost 22 000 symptomatic people over 11 weeks for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a multiplex polymerase chain reaction (PCR) assay. Following travel bans and physical distancing, SARS-CoV-2 and other respiratory viruses diagnoses fell dramatically. Increasing rhinovirus diagnoses as social control measures were relaxed may indirectly indicate an elevated risk of coronavirus disease 2019 (COVID-19) resurgence.
A critique of Shaikh’s two interpretations of Marx’s ‘transformation problem’
Authors: Moseley Fred 
Published: August 2020

Abstract
It is argued in this paper that Shaikh has presented two different interpretations of the transformation problem in his works. In his influential 1977 paper, he presented an “iterative” interpretation in which there is a transfer of value between departments in the economy; and in a series of papers in the 1980s and in his recent book, he presented a different interpretation in which there is a transfer of value between firms in Department 3 and capitalist households. An important common feature of these two different interpretations is that total profit is not equal to total surplus-value. The two interpretations present different explanations of this divergence, which are examined in detail in this paper. It is argued that there is no textual evidence whatsoever to support Shaikh’s second interpretation. A few comparisons will also be made to my “macro-monetary” interpretation of Marx theory according to which there is no transformation problem in Marx’s theory and total profit is always equal to total surplus-value.
WE-CARE IBD SCORE: Assessing High-quality Care From the Perspective of Patients With Inflammatory Bowel Disease
Authors: Barello Serena , Guida Elena , Bonanomi Andrea , Menichetti Julia , Leone Salvatore , Previtali Enrica , Graffigna Guendalina 
Published: August 2020

Abstract

Background and Aims
Patient-reported experience measures [PREMs] are today a core asset to orientate health care quality improvements. They are particularly relevant in clinical situations requiring frequent interactions between patients and the health care system, like inflammatory bowel disease [IBD]. Indeed, IBD chronic care requires continuous therapies, psychological interventions, and follow-ups. The characteristics of health care services play an important role in the life of these patients and in their satisfaction with the care received. The aim of this study was to develop and validate an IBD-specific questionnaire [WE-CARE IBD SCORE] able to capture IBD patients’ needs and priorities for their own health care and based on patients’ perspectives.

Methods
The WE-CARE IBD SCORE was developed and validated through a multistage process [qualitative and quantitative] and administered to 1176 patients with IBD. Psychometric evaluation included an assessment of internal consistency and factor analysis.

Results
The WE-CARE IBD SCORE is a short and self-administered questionnaire that includes six items assessing one unique dimension of ‘IBD patient-reported high quality of care’. Psychometric evaluations demonstrate the reliability [Cronbach’s alpha = 0.93] and validity [invariance to gender and diagnosis] of the questionnaire as an instrument able to detect and assess IBD patients’ main psychosocial needs and priorities for receiving health care services.

Conclusions
The WE-CARE IBD SCORE contributes to the panorama of existing quality of care patient-reported measures by providing a patient-based, psychosocial perspective in the evaluation of a key aspect for chronic—and particularly for IBD patients—care.
Within-Colony Transmission of Microsporidian and Trypanosomatid Parasites in Honey Bee and Bumble Bee Colonies
Authors: Pinilla-Gallego Mario S , Williams Emma E , Davis Abby , Fitzgerald Jacquelyn L , McArt Scott H , Irwin Rebecca E 
Published: August 2020

AbstractParasites are commonly cited as one of the causes of population declines for both managed and wild bees. Epidemiological models sometimes assume that increasing the proportion of infected individuals in a group should increase transmission. However, social insects exhibit behaviors and traits which can dampen the link between parasite pressure and disease spread. Understanding patterns of parasite transmission within colonies of social bees has important implications for how to control diseases within those colonies, and potentially the broader pollinator community. We used bumble bees (Bombus impatiens Cresson) (Hymenoptera: Apidae) and western honey bees (Apis mellifera L.) (Hymenoptera: Apidae) infected with the gut parasites Crithidia bombi (Lipa & Triggiani) (Trypanosomatida: Trypanosomatidae) and Nosema ceranae (Fries et al.) (Dissociodihaplophasida: Nosematidae), respectively, to understand how the initial proportion of infected individuals impacts within-colony spread and intensity of infection of the parasites. In bumble bees, we found that higher initial parasite prevalence increased both the final prevalence and intensity of infection of C. bombi. In honey bees, higher initial prevalence increased the intensity of infection in individual bees, but not the final prevalence of N. ceranae. Measures that reduce the probability of workers bringing parasites back to the nest may have implications for how to control transmission and/or severity of infection and disease outbreaks, which could also have important consequences for controlling disease spread back into the broader bee community.
Prognostic implication of CT-FFR based functional SYNTAX score in patients withde novothree-vessel disease
Authors: Qiao Hong Yan , Li Jian Hua , Schoepf U Joseph , Bayer Richard R , Tinnefeld Fiona C , Di Jiang Meng , Yang Fei , Guo Bang Jun , Zhou Chang Sheng , Ge Ying Qian , Lu Meng Jie , Jiang Jian Wei , Lu Guang Ming , Zhang Long Jiang 
Published: August 2020

AbstractAimsThis study was aimed at investigating whether a machine learning (ML)-based coronary computed tomographic angiography (CCTA) derived fractional flow reserve (CT-FFR) SYNTAX score (SS), ‘Functional SYNTAX score’ (FSSCTA), would predict clinical outcome in patients with three-vessel coronary artery disease (CAD).Methods and resultsThe SS based on CCTA (SSCTA) and ICA (SSICA) were retrospectively collected in 227 consecutive patients with three-vessel CAD. FSSCTA was calculated by combining the anatomical data with functional data derived from a ML-based CT-FFR assessment. The ability of each score system to predict major adverse cardiac events (MACE) was compared. The difference between revascularization strategies directed by the anatomical SS and FSSCTA was also assessed. Two hundred and twenty-seven patients were divided into two groups according to the SSCTA cut-off value of 22. After determining FSSCTA for each patient, 22.9% of patients (52/227) were reclassified to a low-risk group (FSSCTA ≤ 22). In the low- vs. intermediate-to-high (&gt;22) FSSCTA group, MACE occurred in 3.2% (4/125) vs. 34.3% (35/102), respectively (P &lt; 0.001). The independent predictors of MACE were FSSCTA (OR = 1.21, P = 0.001) and diabetes (OR = 2.35, P = 0.048). FSSCTA demonstrated a better predictive accuracy for MACE compared with SSCTA (AUC: 0.81 vs. 0.75, P = 0.01) and SSICA (0.81 vs. 0.75, P &lt; 0.001). After FSSCTA was revealed, 52 patients initially referred for CABG based on SSCTA would have been changed to PCI.ConclusionRecalculating SS by incorporating lesion-specific ischaemia as determined by ML-based CT-FFR is a better predictor of MACE in patients with three-vessel CAD. Additionally, the use of FSSCTA may alter selected revascularization strategies in these patients.
Greenhouse gases emissions from the diet and risk of death and chronic diseases in the EPIC-Spain cohort
Authors: González Carlos A , Bonet Catalina , de Pablo Miguel , Sanchez María José , Salamanca-Fernandez Elena , Dorronsoro Miren , Amiano Pilar , Huerta Jose María , Chirlaque María Dolores , Ardanaz Eva , Barricarte Aurelio , Quirós Jose Ramón , Agudo Antonio , Rivera Ferrer Marta Guadalupe 
Published: August 2020

Abstract

Background
Evidence from the scientific literature shows a significant variation in greenhouse gas (GHG) emissions from the diet, according to the type of food consumed. We aim to analyze the relationship between the daily dietary GHG emissions according to red meat, fruit and vegetables consumption and their relationship with risk of total mortality, and incident risk of chronic diseases.

Methods
We examined data on the EPIC-Spain prospective study, with a sample of 40 621 participants. Dietary GHG emission values were calculated for 57 food items of the EPIC study using mean emission data from a systematic review of 369 published studies.

Results
Dietary GHG emissions (kgCO2eq/day), per 2000 kcal, were 4.7 times higher in those with high red-meat consumption (&gt;140 g/day) than those with low consumption (&lt;70 g/day). The average dietary GHG emissions were similar in males and females, but it was significantly higher in youngest people and in those individuals with lower educational level, as well as for northern EPIC centers of Spain. We found a significant association with the risk of mortality comparing the third vs. the first tertile of dietary GHG emissions [hazard ratio (HR) 1.095; 95% confidence interval (CI) 1.007–1.19; trend test 0.037]. Risk of coronary heart disease (HR 1.26; 95% CI 1.08–1.48; trend test 0.003) and risk of type 2 diabetes (HR 1.24; 95% CI 1.11–1.38; trend test 0.002) showed significant association as well.

Conclusions
Decreasing red-meat consumption would lead to reduce GHG emissions from diet and would reduce risk of mortality, coronary heart disease and type 2 diabetes.
Bariatric surgery proves long-term benefit in patients with cirrhosis
Authors: Izzy Manhal , Angirekula Mounika , Abu Dayyeh Barham K , Bazerbachi Fateh , Watt Kymberly D 
Published: August 2020

Abstract

Background
Obesity is commonly observed in patients with cirrhosis, especially with the increasing prevalence of non-alcoholic steatohepatitis (NASH). Bariatric surgery has been avoided in these patients given concerns about increased perioperative risk; therefore, data are lacking regarding long-term outcomes. In this study, we aimed to evaluate the long-term outcomes of patients with cirrhosis who underwent bariatric surgery.

Methods
We reviewed the charts of adult patients with compensated cirrhosis who underwent bariatric surgery after they were prospectively enrolled between February 23, 2009 and November 9, 2011, and followed in a pilot study for evaluation of bariatric surgery outcomes. Only patients with more than 4 years of follow-up were included in the analysis. Data regarding their liver disease, metabolic status, and survival were collected. A descriptive analysis was performed.

Results
The cohort consisted of 10 patients, of whom 7 were females. The median post-surgical follow-up was 8.7 years (± 1.4 years). All patients had biopsy-proven NASH; two patients had concurrent, untreated hepatitis C infection. During the observation period, there was a mean weight loss of 24 kg (19.2% of total body weight pre surgery, P &lt; 0.001) and only one patient regained weight to the baseline pre-surgical measurement. One patient who was not eligible for transplant developed hepatic encephalopathy 3 years after surgery and later died. The remainder of the patients did not have any hepatic decompensation, cardiovascular event, or mortality. Except for one patient with Gilbert syndrome, bilirubin was normal in all patients at last follow-up.

Conclusions
Bariatric surgery in patients with compensated cirrhosis can lead to sustained weight loss and stable hepatic function on long-term follow-up.
Using onset times from frequent seismic surveys to understand fluid flow at the Peace River Field, Canada
Authors: Hetz Gil , Datta-Gupta Akhil , Przybysz-Jarnut Justyna K , Lopez Jorge L , Vasco D W 
Published: August 2020

SUMMARYOur limited knowledge of the relationship between changes in the state of an aquifer or reservoir and the corresponding changes in the elastic moduli, that is the rock physics model, hampers the effective use of time-lapse seismic observations for estimating flow properties within the Earth. A central problem is the complicated dependence of the magnitude of time-lapse changes on the saturation, pressure, and temperature changes within an aquifer or reservoir. We describe an inversion methodology for reservoir characterization that uses onset times, the calendar time of the change in seismic attributes, rather than the magnitude of the changes. We find that onset times are much less sensitive than magnitudes to the rock physics model used to relate time-lapse observations to changes in saturation, temperature and fluid pressure. We apply the inversion scheme to observations from daily monitoring of enhanced oil recovery at the Peace River field in Canada. An array of 1492 buried hydrophones record seismic signals from 49 buried sources. Time-shifts for elastic waves traversing the reservoir are extracted from the daily time-lapse cubes. In our analysis 175 images of time-shifts are transformed into a single map of onset times, leading to a substantial reduction in the volume of data. These observations are used in conjunction with bottom hole pressure data to infer the initial conditions prior to the injection, and to update the reservoir permeability model. The combination of a global and local inversion scheme produces a collection of reservoir models that are best described by three clusters. The updated model leads to a nearly 70 percent reduction in seismic data misfit. The final set of solutions successfully predict the observed normalized pressure history during the soak and flow-back into the wells between 82 and 175 days into the cyclic steaming operation.
Thermodynamic and financial assessment of concentrated solar power plant hybridized with biomass-based organic Rankine cycle, thermal energy storage, hot springs and CO2 capture systems
Authors: Baral Suresh 
Published: August 2020

Abstract
The present study aims to investigate the thermodynamic and financial aspect of concentrated solar power (CSP) plant hybridized with biomass-based organic Rankine cycle (ORC), thermal energy storage (TES), hot springs and CO2 capture systems. The organic working fluids namely R123, R235fa, D4 and MDM are selected for designing the hybrid system at different operating conditions. The nominal power capacities of the CSP and biomass ORC plants are 1.3 MW and 730 kW respectively. Additionally, a parametric study has been carried out to understand the influencing parameters that affect the system’s performance. From the results, it is revealed that the biomass ORC plant with a hot spring system alone can develop a power of 720 and 640 kW for D4 and MDM respectively. Furthermore, the power generation can be increased with addition of TES in the CSP plant. From the economic point of view, the hybrid system with special focus on CO2 capture could be very profitable if the levelized cost of electricity (LCOE) is fixed at 0.24$/kWh. In this scenario, the payback period is 8 years with an internal rate of return (IRR) more than 8%. Therefore, the hybrid system is thermodynamically and financially attractive for dispatchable electricity.
Treatment Discontinuation Impact on Long-Term (10-Year) Weight Gain and Lipid Metabolism in First-Episode Psychosis: Results From the PAFIP-10 Cohort
Authors: Vázquez-Bourgon Javier , Mayoral-van Son Jaqueline , Gómez-Revuelta Marcos , Juncal-Ruiz María , Ortiz-García de la Foz Víctor , Tordesillas-Gutiérrez Diana , Ayesa-Arriola Rosa , Bioque Miquel , Crespo-Facorro Benedicto 
Published: August 2020

Abstract

Background
Patients with a first episode of psychosis (FEP) are at higher risk of gaining weight and presenting metabolic disturbances, partly related to antipsychotic exposure. Previous studies suggest that treatment discontinuation might have a positive impact on weight in schizophrenia. The aim of this study was to evaluate the effect of treatment discontinuation on weight and metabolic changes in a FEP cohort.

Methods
A total of 209 FEP patients and 57 healthy controls were evaluated at study entry and prospectively at 10-year follow-up. Anthropometric measures and, clinical, metabolic, and sociodemographic data were collected.

Results
Patients discontinuing antipsychotic treatment presented a significantly lower increase in weight and better metabolic parameter results than those still on antipsychotic treatment at 10-year follow-up.

Conclusions
Treatment discontinuation had a positive effect on the weight and metabolic changes observed in FEP patients; however, this effect was not sufficient to reaching a complete reversal to normal levels.
Overview of Portable Assays for the Detection of Mycotoxins, Allergens, and Sanitation Monitoring
Authors: Sarver Ronald W , Almy David J , Bergeron Eric R , Strong Benjamin F , Steiner Brent A , Donofrio Robert , Lupo Anthony J , Gray R Lucas , Sperry Amanda K 
Published: August 2020

Abstract

Background
Many food recalls are related to the presence of undeclared allergens and microorganisms in food products. To reduce these occurrences, portable diagnostic assay kits are available to quantitate mycotoxins, to detect allergens and gluten in foods and on environmental surfaces, and for sanitation monitoring.

Objective
This article reviews diagnostic kits that can detect sources of contamination in food and ingredients as well as on surfaces and clean-in-place rinses.

Method
Mycotoxins and gluten were detected using lateral flow diagnostic assays. Sanitation monitoring of surfaces was completed using a chemiluminescent assay to detect adenosine 5′-triphosphate disodium salt hydrate (ATP) and another assay to detect protein.

Results
Gluten was detected at 10 ppm in spiked commodities and on wet and dry surfaces at 2.5 µg/100cm2. Deoxynivalenol was quantitated in dry distillers grains plus solubles and mean results were within two SDs of those determined by HPLC. The chemiluminescent assay had an LOD of 6 fmol of ATP and was able to detect a 1:10 000 dilution of orange juice from surfaces. The protein assay detected 5 µg of bovine serum albumin (BSA) directly applied to the sampler, 100 µg of BSA on surfaces, and detected 1:10 dilutions of Greek yogurt and raw beef from surfaces.

Conclusions
Portable diagnostic kits evaluated in this work provided accurate, rapid, and sensitive results for detection of mycotoxins, gluten, proteins, and ATP. These methods can be used in facilities with minimal training and provide results that are important to ensure food safety.

Highlights
Portable methods to detect gluten, mycotoxins, proteins, and ATP are presented.
Comparing the Real-World Effectiveness of High- Versus Low-Volume Split Colonoscopy Preparations: An Experience Through the British Columbia Colon Cancer Screening Program
Authors: Lee Joseph G H , Telford Jennifer J , Galorport Cherry , Yonge Jordan , Macdonnell Christopher A , Enns Robert A 
Published: August 2020

Abstract

Background
The British Columbia Colon Screening Program (BCCSP) is a population-based colon cancer screening program. In December 2018, physicians in Vancouver, Canada agreed to switch from a low-volume split preparation to a high-volume polyethylene glycol preparation after a meta-analysis of studies suggested superiority of the higher volume preparation in achieving adequate bowel cleansing and improving adenoma detection rates.

Aims
To compare the quality of bowel preparation and neoplasia detection rates using a high-volume split preparation (HVSP) versus a low-volume split preparation (LVSP) in patients undergoing colonoscopy in the BCCSP.

Methods
A retrospective review of patients undergoing colonoscopy through the BCCSP at St. Paul’s Hospital from July 2017 to November 2018 and December 2018 to November 2019 was conducted. Inclusion criteria included age 50 to 74 and patients undergoing colonoscopy through the BCCSP. Variables collected included patient demographics and bowel preparation quality. Rates of bowel preparation and neoplasia detection were analyzed using chi-squared test.

Results
A total of 1453 colonoscopies were included, 877 in the LVSP group and 576 in the HVSP group. No statistically significant difference was noted between rates of inadequate bowel preparation (LVSP 3.6% versus HVSP 2.8%; P = 0.364). Greater rates of excellent (48.4% versus 40.1%; P = 0.002) and optimal (90.1% versus 86.5%; P = 0.041) bowel preparation were achieved with HVSP. The overall adenoma detection rate was similar between the two groups (LVSP 53.1% versus HVSP 54.0%; P = 0.074). LVSP demonstrated higher overall sessile serrated lesion detection rate (9.5% versus 5.6%; P = 0.007).

Conclusions
Compared to LVSP, HVSP was associated with an increase in excellent and optimal bowel preparations, but without an improvement in overall neoplasia detection.
Germline Sequencing DNA Repair Genes in 5545 Men With Aggressive and Nonaggressive Prostate Cancer
Authors: Darst Burcu F , Dadaev Tokhir , Saunders Ed , Sheng Xin , Wan Peggy , Pooler Loreall , Xia Lucy Y , Chanock Stephen , Berndt Sonja I , Gapstur Susan M , Stevens Victoria , Albanes Demetrius , Weinstein Stephanie J , Gnanapragasam Vincent , Giles Graham G , Nguyen-Dumont Tu , Milne Roger L , Pomerantz Mark , Schmidt Julie A , Mucci Lorelei , Catalona William J , Hetrick Kurt N , Doheny Kimberly F , MacInnis Robert J , Southey Melissa C , Eeles Rosalind A , Wiklund Fredrik , Kote-Jarai Zsofia , Conti David V , Haiman Christopher A 
Published: August 2020

Abstract

Background
There is an urgent need to identify factors specifically associated with aggressive prostate cancer (PCa) risk. We investigated whether rare pathogenic, likely pathogenic, or deleterious (P/LP/D) germline variants in DNA repair genes are associated with aggressive PCa risk in a case-case study of aggressive vs nonaggressive disease.

Methods
Participants were 5545 European-ancestry men, including 2775 nonaggressive and 2770 aggressive PCa cases, which included 467 metastatic cases (16.9%). Samples were assembled from 12 international studies and germline sequenced together. Rare (minor allele frequency &lt; 0.01) P/LP/D variants were analyzed for 155 DNA repair genes. We compared single variant, gene-based, and DNA repair pathway-based burdens by disease aggressiveness. All statistical tests are 2-sided.

Results
BRCA2 and PALB2 had the most statistically significant gene-based associations, with 2.5% of aggressive and 0.8% of nonaggressive cases carrying P/LP/D BRCA2 alleles (odds ratio [OR] = 3.19, 95% confidence interval [CI] = 1.94 to 5.25, P = 8.58 × 10-7) and 0.65% of aggressive and 0.11% of nonaggressive cases carrying P/LP/D PALB2 alleles (OR = 6.31, 95% CI = 1.83 to 21.68, P = 4.79 × 10-4). ATM had a nominal association, with 1.6% of aggressive and 0.8% of nonaggressive cases carrying P/LP/D ATM alleles (OR = 1.88, 95% CI = 1.10 to 3.22, P = .02). In aggregate, P/LP/D alleles within 24 literature-curated candidate PCa DNA repair genes were more common in aggressive than nonaggressive cases (carrier frequencies = 14.2% vs 10.6%, respectively; P = 5.56 × 10-5). However, this difference was non-statistically significant (P = .18) on excluding BRCA2, PALB2, and ATM. Among these 24 genes, P/LP/D carriers had a 1.06-year younger diagnosis age (95% CI = -1.65 to 0.48, P = 3.71 × 10-4).

Conclusions
Risk conveyed by DNA repair genes is largely driven by rare P/LP/D alleles within BRCA2, PALB2, and ATM. These findings support the importance of these genes in both screening and disease management considerations.