bluuebunny/crossref_metadata_2025_split huggingface dataset:
Usefulness of CogEvo, a computerized cognitive assessment and training tool, for distinguishing patients with mild Alzheimer's disease and mild cognitive impairment from cognitively normal older people
Authors: Takechi Hajime , Yoshino Hiroshi 
Published: December 2020

AimThis study aimed to assess whether CogEvo, a computerized cognitive assessment and training tool, could distinguish patients with mild Alzheimer's disease and mild cognitive impairment from cognitively normal older people.MethodsThis cross‐sectional study enrolled 166 participants with Alzheimer's disease, mild cognitive impairment and cognitively normal older people. In CogEvo, five types of cognitive tasks were carried out, and the z‐scores were used as a composite score. Logistic regression and receiver operating characteristics analyses were then carried out to evaluate the usefulness of CogEvo in distinguishing between the three groups.ResultsCogEvo and Mini‐Mental State Examination scores showed excellent correlation, and could significantly differentiate between the Alzheimer's disease, mild cognitive impairment and cognitively normal older people groups (Mini‐Mental State Examination 20.4 ± 3.5, 25.5 ± 1.6 and 27.6 ± 2.0, respectively; CogEvo: −1.9 ± 0.9, −0.8 ± 0.8 and 0.0 ± 1.0, respectively; both P < 0.001 by analysis of variance). Logistic regression analysis adjusted for age, sex and years of education significantly differentiated the mild cognitive dysfunction group (mild cognitive impairment plus mild Alzheimer's disease; n = 78) from the cognitively normal group (n = 88) (P < 0.001), whereas receiver operating characteristics analysis showed moderate accuracy (area under the receiver operating characteristic curve 0.830).ConclusionsThese results suggest that CogEvo, a computerized cognitive assessment tool, is useful for evaluating early‐stage cognitive impairment. Further studies are required to assess its effectiveness as a combination assessment and training tool. Geriatr Gerontol Int 2021; 21: 192–196.
Increased case‐finding and uptake of direct‐acting antiviral treatment essential for micro‐elimination of hepatitis C among people living with HIV: a national record linkage study
Authors: McLeod A , Hutchinson SJ , Smith S , Leen C , Clifford S , McAuley A , Wallace LA , Barclay ST , Bramley P , Dillon JF , Fraser A , Gunson RN , Hayes PC , Kennedy N , Peters E , Templeton K , Goldberg DJ 
Published: December 2020

ObjectivesMicro‐elimination of hepatitis C virus (HCV) in people living with HIV (PLHIV) and co‐infected with HCV has been proposed as a key contribution to the overall goal of HCV elimination. While other studies have examined micro‐elimination in HIV‐treated cohorts, few have considered HCV micro‐elimination among those not treated for HIV or at a national level.MethodsThrough data linkage of national and sentinel surveillance data, we examined the extent of HCV testing, diagnosis and treatment among a cohort of PLHIV in Scotland identified through the national database of HIV‐diagnosed individuals, up to the end of 2017.ResultsOf 5018 PLHIV, an estimated 797 (15%) had never been tested for HCV and 70 (9%) of these had undiagnosed chronic HCV. The odds of never having been tested for HCV were the highest in those not on HIV treatment [adjusted odds ratio (aOR) = 7.21, 95% confidence interval (CI): 5.15–10.10). Overall HCV antibody positivity was 11%, and it was at its highest among people who inject drugs (49%). Most of those with chronic HCV (91%) had attended an HCV treatment clinic but only half had been successfully treated (54% for those on HIV treatment, 12% for those not) by the end of 2017. The odds of never having been treated for HCV were the highest in those not on HIV treatment (aOR = 3.60, 95% CI: 1.59–8.15).ConclusionsOur data demonstrate that micro‐elimination of HCV in PLHIV is achievable but progress will require increased effort to engage and treat those co‐infected, including those not being treated for their HIV.
Does Twitter Happiness Sentiment predict cryptocurrency?
Authors: Naeem Muhammad Abubakr , Mbarki Imen , Suleman Muhammed Tahir , Vo Xuan Vinh , Shahzad Syed Jawad Hussain 
Published: December 2020

AbstractWe examine the predictive ability of Twitter Happiness Sentiment for six major cryptocurrencies using daily data from August 7, 2015 to December 31, 2019. At first instance, our results conclude a significant nonlinear relationship between Twitter Happiness Sentiment and cryptocurrencies. The nonlinear dependence structure is further enhanced when using the quantile‐on‐quantile (QQ) analysis, which indicates that high and low sentiment predicts returns of five cryptocurrencies. These findings are statistically and economically significant.
Effects of Aloe vera in adults with mucocutaneous problems: A systematic review and meta‐analysis
Authors: Gok Metin Zehra , Helvaci Aylin , Gulbahar Eren Merve 
Published: December 2020

AbstractAimsTo analyse the different types of Aloe vera (AV) effects on various mucocutaneous problems among adults.DesignA systematic review and meta‐analysis.Data SourcesAn exhaustive scanning of PubMed, Medline, ScienceDirect, and Google Scholar databases was conducted from January 2000–December 2019.Review MethodsRandomized controlled trials (RCTs) publishing reports on the effects of AV in various mucocutaneous problems, psoriasis, burn, wound‐healing were included. The standardized mean differences (SMD) with 95% confidence Intervals (CIs) were determined for the main outcomes, heterogeneity was analysed using theI2test and the risk of bias in the studies was reviewed by the Cochrane risk of bias assessment tool.ResultsThe study included 23 trials with a total of 4,023 participants. Six trials were included in the meta‐analysis. The results indicated no significant differences in pain scores as assessed by the Visual Analog Scale (VAS) (SMD = 0.11, 95% CI: −0.37 to 0.59). The Psoriasis Area Severity Index (PASI) scores were significantly lower following AV gel application in two of the studies (SMD = −1.32 95% CI: −1.86 to −0.78). Considering results in a systematic manner, AV accelerated tissue epithelialization and wound‐healing process (N = 3), reduced oral mucositis (N = 3), and improved quality of life (N = 1).ConclusionAV might have beneficial effects in reducing pain scores and the severity of mucocutaneous problems compared with placebo, especially with limited mild to moderate adverse effects.ImpactAV may be used as an alternative and integrative approach to reducing symptom severity in mucocutaneous problems and the wound‐healing process. High quality and well‐designed RCTs are still needed to elucidate the effects of AV in a variety of dosages and forms among adults with mucocutaneous problems.
Women and atrial fibrillation
Authors: Volgman Annabelle Santos , Benjamin Emelia J. , Curtis Anne B. , Fang Margaret C. , Lindley Kathryn J. , Naccarelli Gerald V. , Pepine Carl J. , Quesada Odayme , Vaseghi Marmar , Waldo Albert L. , Wenger Nanette K. , Russo Andrea M. ,   American College of Cardiology Committee on Cardiovascular Disease in Women
Published: December 2020

AbstractAtrial fibrillation (AF) remains a growing problem in the United States and worldwide, imposing a high individual and health system burden, including increased resource consumption due to repeated hospitalizations, stroke, dementia, heart failure, and death. This comprehensive review summarizes the most recent data on sex‐related differences in risks associated with AF. Women with AF have increased risk of stroke and death compared to men, and possible reasons for this disparity are explored. Women also continue to have worse symptoms and quality of life, and poorer outcomes with stroke prevention, as well as with rate and rhythm control management strategies. Many current rhythm control treatment strategies for AF, including cardioversion and ablation, are used less frequently in women as compared to men, whereas women are more likely to be treated with rate control strategies or antiarrhythmic drugs. Sex differences should be considered in treating women with AF to improve outcomes and women and men should be offered the same interventions for AF. We need to improve the evidence base to understand if variation in utilization of rate and rhythm control management between men and women represents health inequities or appropriate clinical judgement.
The protective effect of isosteviol sodium on cardiac function and myocardial remodelling in transverse aortic constriction rat
Authors: Ke Qingjin , Liu Fei , Tang Yuxin , Chen Jiedi , Hu Hui , Sun Xiaoou , Tan Wen 
Published: December 2020

AbstractPathological hypertrophy contributes to heart failure and there is not quite effective treatment to invert this process. Isosteviol has been shown to protect the heart against ischaemia‐reperfusion injury and isoproterenol‐induced cardiac hypertrophy, but its effect on pressure overload‐induced cardiac hypertrophy is still unknown. Pressure overload induced by transverse aortic constriction (TAC) causes cardiac hypertrophy in rats to mimic the pathological condition in human. This study examined the effects of isosteviol sodium (STVNa) on cardiac hypertrophy by the TAC model and cellular assays in vitro. Cardiac function test, electrocardiogram analysis and histological analysis were conducted. The effects of STVNa on calcium transient of the adult rat ventricular cells and the proliferation of neonatal rat cardiac fibroblasts were also studied in vitro. Cardiac hypertrophy was observed after 3‐week TAC while the extensive cardiac dysfunction and electronic remodelling were observed after 9‐week TAC. Both STVNa and sildenafil (positive drug) treatment reversed the two process, but STVNa appeared to be more superior in some aspects and did not change calcium transient considerably. STVNa also reversed TAC‐induced cardiac fibrosis in vivo and TGF‐β1‐induced fibroblast proliferation in vitro. Moreover, STVNa, but not sildenafil, reversed impairment of the autonomic nervous system induced by 9‐week TAC.
Mortality and pre‐hospitalization use of low‐dose aspirin in COVID‐19 patients with coronary artery disease
Authors: Yuan Shuai , Chen Peng , Li Huaping , Chen Chen , Wang Feng , Wang Dao Wen 
Published: December 2020

AbstractTo determine whether pre‐hospitalization use of aspirin is associated with all‐cause mortality in coronavirus disease 2019 (COVID‐19) patients with coronary artery disease (CAD). We recruited 183 adult patients with CAD diagnosed with COVID‐19, including 52 taking low‐dose aspirin (mean [SD] age, 69.7 [1.1] years; 59.6% men) and 131 without using aspirin (mean [SD] age, 71.8 [0.9] years; 51.9% men), who were admitted in the Tongji hospital in Wuhan, China from January 10, 2020 to March 30, 2020. There was no difference on in‐hospital mortality between aspirin group and non‐aspirin group (21.2% vs. 22.1%, P = .885). Similarly, for critically severe COVID‐19 patients, the mortality in aspirin group was close to that in non‐aspirin group (44% vs. 45.9%, P = .872). Moreover, the percentage of patients with CAD taking low‐dose aspirin did not differ between those survivors and non‐survivors (28.7% vs. 27.5%, P = .885). Meanwhile, the usage of aspirin was not correlated with all‐cause mortality in multivariate analysis (OR = 0.944, 95% CI: 0.411‐2.172, P = .893). Collectively, our study suggested that the pre‐hospitalization use of low‐dose aspirin was not associated with the clinical outcome of patients with CAD hospitalized with COVID‐19 infections.
Automating autism assessment: What AI can bring to the diagnostic process
Authors: Erden Yasemin J. , Hummerstone Harriet , Rainey Stephen 
Published: December 2020

AbstractThis paper examines the use of artificial intelligence (AI) for the diagnosis of autism spectrum disorder (ASD, hereafter autism). In so doing we examine some problems in existing diagnostic processes and criteria, including issues of bias and interpretation, and on concepts like the ‘double empathy problem’. We then consider how novel applications of AI might contribute to these contexts. We're focussed specifically on adult diagnostic procedures as childhood diagnosis is already well covered in the literature.
Adnexal torsion without neoplastic lesions after laparoscopic hysterectomy: A report of three cases and literature review
Authors: Ogawa Chiemi , Amano Tsukuru , Higuchi Asuka , Tsuji Shunichiro , Kimura Fuminori , Murakami Takashi 
Published: December 2020

AbstractThe major risk factor for adnexal torsion is the presence of adnexal neoplasms, and torsion without a neoplastic lesion of the adnexa is rare. We report three cases of right adnexal torsion without neoplastic lesion after laparoscopic hysterectomy. In all three cases, the right adnexas, which did not form adhesions, had undergone torsion. According to several case reports, most cases of adnexal torsion after laparoscopic hysterectomy developed without neoplastic lesion. In fact, adnexal torsion without neoplasm is reported to occur relatively frequently after laparoscopic hysterectomy and more commonly involves the right side. Therefore, at the end of laparoscopic hysterectomy, ovariopexy should be performed to prevent postoperative adnexal torsion.
Use of music in reducing pain during outpatient hysteroscopy: Prospective randomized trial
Authors: Law Ho Ying , Ng Dorothy Yuet Tao , Chung Carmen Diana 
Published: December 2020

AbstractAimTo evaluate the effect of music in reducing pain during outpatient hysteroscopy under no anesthesia.MethodsWe conducted a prospective randomized controlled trial From June 2019 to December 2019 in Pamela Youde Nethersole Eastern Hospital in Hong Kong. A total of 107 patients were randomized to music group (n = 54) or non‐music group (n = 53). Music was played during outpatient hysteroscopy in the music group. Patients in the non‐music group had the procedure done in the same setting without music. Primary outcome was the level of pain measured using the visual analog scale (VAS) score before and during the procedure. Secondary outcomes were vital parameters that reflect the level of pain including blood pressure and heart rate.ResultsPatients in the music group experienced significantly less pain during outpatient hysteroscopy (VAS score 4.54 ± 2.89 vs 5.88 ± 2.90; P = 0.02). The anticipated pain level was similar in both groups (VAS score 5.59 ± 2.27 vs 6.11 ± 2.43; P = 0.27). There was no statistically significant difference between the two groups in all the vital parameters.ConclusionListening to music during outpatient hysteroscopy under no anesthesia significantly reduces pain in a well‐matched Chinese population. Music is easy to provide with low‐cost equipment and manpower. We recommend the routine use of music during outpatient hysteroscopy to improve patient care.
Transabdominal ultrasound guided oocyte retrieval using vaginal ultrasound probe: Definition of the technique
Authors: Sönmezer Murat , Gülümser Çağrı , Sönmezer Meltem , Sükür Yavuz Emre , Atabekoğlu Cem 
Published: December 2020

AbstractPurposeTo define whether transabdominal ultrasound guided oocyte retrieval (TUGOR) is a feasible, effective and safe method.MethodsA total of 64 patients who underwent TUGOR in a tertiary referral university hospital in vitro fertilization (IVF) clinic were enrolled. Indications, total number of oocytes collected, total number and percentage of mature oocytes, duration of procedure, complication rates and total number of fertilized oocytes were assessed.ResultsThe indications for TUGOR were as follows; virgin women with decreased ovarian reserve who opted fertility preservation (n = 52, 81.1%), Ewing Sarcoma (n = 1, 1.56%), breast cancer (n = 4, 6.2%), lymphoma (n = 1, 1.56%) endometrioma (n = 1, 1.56%), immature teratoma of the ovary (n = 1, 1.56%), multiple large uterine fibroids (n = 2, 3.1%), adnexal transposition due to bowel surgery (n = 1, 1.56%) and Mayer Rokitansky Küster Hauser Syndrome (n = 1, 1.56%). Total number of oocytes retrieved and mean number of oocytes collected were 315 and 4.92 ± 1.7 (range 1–21), respectively. The mean duration of the procedure was 12.4 ± 1.2 min. The number and percentage of mature oocytes were 272 and 86.3%, respectively. A total of 14 embryos were frozen in four patients and one blastocyst transfer was performed ending up with live birth. Superficial epigastric artery injury occurred in two patients and resolved spontaneously. No oocyte was retrieved in five patients with single growing follicle in the first attempt.ConclusionTUGOR is a feasible, effective and safe method of oocyte retrieval for the purpose of fertility preservation or in patients with inaccessible ovaries via transvaginal route undergoing IVF.
Challenging procedures used in systematic reviews by promoting a case‐based approach to the analysis of qualitative methods in nursing trials
Authors: Creamer Elizabeth G. , Guetterman Timothy C. , Govia Ishtar , Fetters Michael D. 
Published: December 2020

AbstractThis methodological discussion invites critical reflection about the procedures used to analyze the contribution of qualitative and mixed methods research to nursing trials by mounting an argument that these should rest on multiple publications produced about a project, rather than a single article. We illustrate the value‐added of this approach with findings from a qualitative, cross‐case analysis of three critical case exemplars from nursing researchers that each used a qualitative approach with a mixed method phase. The holistic lens afforded by a case‐based approach informs nursing inquiry by documenting that the critical case exemplars presented evidence of (a) a sustained commitment of resources and expertise for the qualitative methods that extended across more than one phase of the trial, (b) the impact of the qualitative methods on the trial or its aftermath, (c) deploying a theoretical or conceptual framework for a variety of purposes, and (d) integrating qualitative and quantitative data for purposes of extending explanatory power. Findings challenge the practice of linking purposes served by qualitative and mixed methods to a single trial phase.
Epidermolysis bullosa pruriginosa treated with dupilumab
Authors: Zhou Amanda G. , Little Alicia J. , Antaya Richard J. 
Published: December 2020

AbstractEpidermolysis bullosa pruriginosa (EBP) is a variant of dystrophic epidermolysis bullosa characterized by intense pruritus and prurigo nodularis‐like lesions. While medical therapies for EBP exist, current treatments are not consistently effective, and symptoms often cause decreased quality of life. Here, we report two cases of EBP treated with dupilumab, which decreased symptoms of pruritus and improved skin findings. Both patients have been on dupilumab for over one year with sustained improvement and no adverse effects; although in one patient, increased dosing was required to attain optimal control of disease.
Comparative analysis of the light parameters of red and near‐infrared diode lasers to induce photobiomodulation on fibroblasts and keratinocytes: An in vitro study
Authors: Topaloglu Nermin , Özdemir Merve , Çevik Ziyşan Buse Yaralı 
Published: December 2020

AbstractBackgroundPhotobiomodulation (PBM) depends on the use of non‐ionizing light energy to trigger photochemical changes, particularly in light‐sensitive mitochondrial structures. It triggers proliferation and the metabolic activity of the cells, primarily by utilizing the energy from the near‐infrared to the red wavelength of the light.PurposeThis in vitro study has analyzed comparatively the most appropriate energy doses and wavelengths to induce PBM on keratinocytes and fibroblasts for the accelerated wound healing process.Methods1, 3, and 5 J/cm2 energy densities of 655 and 808‐nm diode lasers were used to promote cell proliferation and wound healing process. Scratch assay and MTT analysis were performed on keratinocytes and fibroblasts for wound closure and cell proliferation after the triple light applications, respectively.Results655‐nm of wavelength was more successful on keratinocytes to induce wound healing and cell proliferation, whereas 808‐nm of wavelength was so effective on fibroblasts to heal the wounds totally and it induced cell proliferation almost 3 times compared to the untreated control group.ConclusionThis study revealed that PBM with 655 and 808 nm of wavelengths was effective to speed up the wound healing process at specific energy densities. In general 808‐nm of wavelength was more successful. However, the proper wavelength and the energy density may differ according to the cell type. Thus, every light parameter should be chosen properly to obtain better outcomes during PBM applications.
Cohort Profile: The Shanghai Sleep Birth Cohort Study
Authors: Lin Jianfei , Sun Wanqi , Song Yuanjin , Dong Shumei , Lin Qingmin , Deng Yujiao , Meng Min , Zhu Qi , Jiang Yanrui , Wang Guanghai , Tong Shilu , Liu Shijian , Mei Hao , Jiang Fan 
Published: December 2020

AbstractBackgroundSleep disturbances in women occur frequently throughout pregnancy. Previous studies have demonstrated that the increasing incidence of physiological and psychological illness is concurrent with increasing sleep deprivation and poor sleep quality in adults and children.ObjectivesThe Shanghai Sleep Birth Cohort Study (SSBCS) was established to examine the effect of sleep disturbances during the third trimester on emotional regulation of mothers; to assess the effect of maternal sleep during pregnancy on the growth and development of children; and to explore the influence of children's sleep characteristics on physical and social‐emotional development.PopulationThe study was conducted in the Renji Hospital in Pudong New District, Shanghai from May 2012 to July 2013. Women and their newborns who met the inclusion criteria and agreed to participate in this study were recruited to the SSBCS.MethodsThe follow‐up visits for children were conducted at the age of 42 days, 3, 6, 9, 12, 18, and 24 months, and 3, 4, and 6 years. Data on demographic factors, physical examination, sleep assessment, developmental and psychiatric assessment, diet records, and biological samples were collected throughout the study.Preliminary resultsA total of 277 pregnant women were recruited to the study; the response rate was 64.3%. 37.9% of the pregnant women had poor sleep quality and 12.0% suffered from depression. Infant sleep patterns changed during the first year of life, but most sleep characteristics showed little variation from 6 to 12 months.ConclusionsThe SSBCS is an on‐going prospective cohort study with follow‐up to 6 years. The detailed data on demographic factors, sleep assessment, physical examinations, neurodevelopmental and psychiatric assessment, diet records, and biological samples make this research platform an important resource for examining the potential effects of sleep characteristics on both maternal and child health.