bluuebunny/crossref_metadata_2025_split huggingface dataset:
A common binding motif in the ET domain of BRD3 forms polymorphic structural interfaces with host and viral proteins
Authors: Aiyer Sriram , Swapna G.V.T. , Ma Li-Chung , Liu Gaohua , Hao Jingzhou , Chalmers Gordon , Jacobs Brian C. , Montelione Gaetano T. , Roth Monica J. 
Published: September 2020

SummaryThe extra-terminal (ET) domain of BRD3 is conserved among BET proteins (BRD2, BRD3, BRD4), interacting with multiple host and viral protein-protein networks. Solution NMR structures of complexes formed between BRD3-ET domain with either the 79-residue murine leukemia virus integrase (IN) C-terminal domain (IN329-408), or its 22-residue IN tail peptide (TP) (IN386-407) alone, reveal similar intermolecular three-stranded β-sheet formation.15N relaxation studies reveal a 10-residue linker region (IN379-388) tethering the SH3 domain (IN329-378) to the ET-binding motif (IN389-405)-ET complex. This linker has restricted flexibility, impacting its potential range of orientations in the IN - nucleosome complex. The complex of the ET-binding peptide of host NSD3 protein (NSD3148-184) and BRD3-ET domain includes a similar three-stranded β-sheet interaction, but the orientation of the β−hairpin is flipped compared to the two IN : ET complexes. These studies expand our understanding of molecular recognition polymorphism in complexes of ET-binding motifs with viral and host proteins.HighlightsThe BRD3 ET domain binds to key peptide motifs of diverse host and viral proteins.These complexes reveal conformational plasticity in molecular recognition.NMR studies demonstrate restricted interdomain motion in the IN CTD / ET complex.A cost-effective approach is described for producing isotopically-labeled peptides.Etoc BlurbWe address structurally how the MLV Integrase (IN) usurps the host function of the BET protein through comparative studies of the IN : Brd3 ET complex with that of the host NSD3. MLV integration and thus its pathogenesis is driven through protein interactions of the IN : BET family.
Identifying candidateCulicoidesspp. (Diptera: Ceratopogonidae) for the study of interactions withCandidatusCardinium hertigii (Bacteroidetes)
Authors: Pilgrim Jack , Siozios Stefanos , Baylis Matthew , Venter Gert , Garros Claire , Hurst Gregory D. D. 
Published: September 2020

AbstractCulicoidesbiting midges (Diptera: Ceratopogonidae) are disease vectors responsible for the transmission of several viruses of economic and animal health importance. The recent deployment ofWolbachiawith pathogen-blocking capacity to control viral disease transmission by mosquitoes has led to a focus on the potential use of endosymbionts to control arboviruses transmitted by other vector species. Previous screens ofCulicoideshave described the presence ofCandidatusCardinium hertigii (Bacteroidetes). However, the biological impact of this symbiont is yet to be uncovered and awaits a suitable system to studyCardinium-midge interactions. To identify candidate species to investigate these interactions, accurate knowledge of the distribution of the symbiont withinCulicoidespopulations is needed. We used a sensitive nested PCR assay to screenCardiniuminfection in 337 individuals of 25Culicoidesspecies from both Palearctic and Afrotropical regions. Infections were observed in several vector species includingC. imicolaand the pulicaris complex (C. pulicaris, C. bysta, C. newsteadiandC. punctatus) with prevalence ranging from low and intermediate, to fixation. Infection inC. pulicariswas very rare in comparison to a previous study, and there is evidence the prior record of high prevalence represents a laboratory contamination error. Phylogenetic analysis based on the Gyrase B gene sequence grouped all new isolates within “group C” of the genus, a clade which has to date been exclusively described inCulicoides. Through a comparison of our results with previous screens, we evaluate the suitability ofCardinium-infected species for future work pertaining to the symbiont.
An Interpreted Atlas of Biosynthetic Gene Clusters from 1000 Fungal Genomes
Authors: Robey Matthew T. , Caesar Lindsay K. , Drott Milton T. , Keller Nancy P. , Kelleher Neil L. 
Published: September 2020

AbstractFungi are prolific producers of natural products, compounds which have had a large societal impact as pharmaceuticals, mycotoxins, and agrochemicals. Despite the availability of over 1000 fungal genomes and several decades of compound discovery efforts from fungi, the biosynthetic gene clusters (BGCs) encoded by these genomes and the associated chemical space have yet to be analyzed systematically. Here we provide detailed annotation and analyses of fungal biosynthetic and chemical space to enable genome mining and discovery of fungal natural products. Using 1037 genomes from species across the fungal kingdom (e.g., Ascomycota, Basidiomycota, and non-Dikarya taxa), 36,399 predicted BGCs were organized into a network of 12,067 gene cluster families (GCFs). Anchoring these GCFs with reference BGCs enabled automated annotation of 2,026 BGCs with predicted metabolite scaffolds. We performed parallel analyses of the chemical repertoire of Fungi, organizing 15,213 fungal compounds into 2,945 molecular families (MFs). The taxonomic landscape of fungal GCFs is largely species-specific, though select families such as the equisetin GCF are present across vast phylogenetic distances with parallel diversifications in the GCF and MF. We compare these fungal datasets with a set of 5,453 bacterial genomes and their BGCs and 9,382 bacterial compounds, revealing dramatic differences between bacterial and fungal biosynthetic logic and chemical space. These genomics and cheminformatics analyses reveal the large extent to which fungal and bacterial sources represent distinct compound reservoirs. With a >10-fold increase in the number of interpreted strains and annotated BGCs, this work better regularizes the biosynthetic potential of fungi for rational compound discovery.Significance StatementFungi represent an underexploited resource for new compounds with applications in the pharmaceutical and agriscience industries. Despite the availability of >1000 fungal genomes, our knowledge of the biosynthetic space encoded by these genomes is limited and ad hoc. We present results from systematically organizing the biosynthetic content of 1037 fungal genomes, providing a resource for data-driven genome mining and large-scale comparison of the genetic and molecular repertoires produced in fungi and compare to those present in bacteria.
Experiences of receiving and providing maternity care during the COVID-19 Pandemic in Australia: a five-cohort cross-sectional comparison
Authors: Bradfield Zoe , Wynter Karen , Hauck Yvonne , Vasilevski Vidanka , Kuliukas Lesley , Wilson Alyce N , Szabo Rebecca A , Homer Caroline SE , Sweet Linda 
Published: September 2020

AbstractIntroductionThe global COVID-19 pandemic has radically changed the way health care is delivered in many countries around the world. Evidence on the experience of those receiving or providing maternity care is important to guide practice through this challenging time.MethodsA cross-sectional study was conducted in Australia. Five key stakeholder cohorts were included to explore and compare the experiences of those receiving or providing care during the COVID-19 pandemic. Women, their partners, midwives, medical practitioners and midwifery students who had received or provided maternity care from March 2020 onwards in Australia were invited to participate in an online survey. which was released between 13th May and 24th June 2020; a total of 3701 completed responses were received.FindingsWhile anxiety related to COVID-19 was high among all five cohorts, there were statistically significant differences between the responses from each cohort for most survey items. Women were more likely to indicate concern about their own and family’s health and safety in relation to COVID-19 whereas midwives, doctors and midwifery students were more likely to be concerned about occupational exposure to COVID-19 through working in a health setting than those receiving care through attending these environments. Midwifery students and women’s partners were more likely to respond that they felt isolated because of the changes to the way care was provided. Despite concerns about care received or provided not meeting expectations, most respondents were satisfied with the quality of care provided, although midwives and midwifery students were less likely to agree.ConclusionThis paper provides a unique exploration and comparison of experiences of receiving and providing maternity care during the COVID-19 pandemic in Australia. Findings are useful to support further service changes and future service redesign. New evidence provided offers unique insight into key stakeholders’ experiences of the rapid changes to health services.
A closer look at stochastic frontier analysis in economics
Authors: Nguyen Hung T. 
Published: September 2020

Purpose
While there exist many surveys on the use stochastic frontier analysis (SFA), many important issues and techniques in SFA were not well elaborated in the previous surveys, namely, regular models, copula modeling, nonparametric estimation by Grenander’s method of sieves, empirical likelihood and causality issues in SFA using regression discontinuity design (RDD) (sharp and fuzzy RDD). The purpose of this paper is to encourage more research in these directions.

Design/methodology/approach
A literature survey.

Findings
While there are many useful applications of SFA to econometrics, there are also many important open problems.

Originality/value
This is the first survey of SFA in econometrics that emphasizes important issues and techniques such as copulas.
Pocket parks for promoting social interaction among residents of Baghdad City
Authors: Salih Sarah Abdulkareem , Ismail Sumarni , Mseer Aysha 
Published: September 2020

PurposeThe residents of Baghdad city has been suffering from various issues, including poor social relations, low quality of life, as well as neglect of many public spaces and small parks. Therefore, there is a need to devise effective alternatives to compensate for the loss of large public open spaces so as to enhance the residents’ social interactions and other social activities. Having that said, this study identified the types and characteristics of public open spaces to enhance residents’ social activities in Baghdad city.Design/methodology/approachThis study adopted the questionnaire survey method to gather quantitative data from 306 respondents based on the single-stage random procedure. The targeted population of this study refers to the residents of the Karkh district, the western part of Baghdad.FindingsThe study outcomes highlight the need to provide pocket parks with adequate characteristics to promote the residents’ social interactions in Baghdad city.Practical implicationsThis study contributes by emphasizing the significance of establishing pocket parks for social interaction in Baghdad City.Originality/valueThe study shows a number of solutions related to pocket parks by studying the critical actionable attributes that can be embedded into new development, land-use policies, or to upgrade existing parks. The study may serve as a useful reference for urban and landscape planners, architects, social psychologists, the Municipal of Baghdad, and other interested researchers in this field.
Expectations and everyday opportunities for building trust in the food system
Authors: Tonkin Emma , Henderson Julie , Meyer Samantha B. , Coveney John , Ward Paul R. , McCullum Dean , Webb Trevor , Wilson Annabelle M. 
Published: September 2020

PurposeConsumers’ trust in food systems is essential to their functioning and to consumers’ well-being. However, the literature exploring how food safety incidents impact consumer trust is theoretically underdeveloped. This study explores the relationship between consumers’ expectations of the food system and its actors (regulators, food industry and the media) and how these influence trust-related judgements that consumers make during a food safety incident.Design/methodology/approachIn this study, two groups of purposefully sampled Australian participants (n = 15) spent one day engaged in qualitative public deliberation to discuss unfolding food incident scenarios. Group discussion was audio recorded and transcribed for the analysis. Facilitated group discussion included participants' expected behaviour in response to the scenario and their perceptions of actors' actions described within the scenario, particularly their trust responses (an increase, decrease or no change in their trust in the food system) and justification for these.FindingsThe findings of the study indicated that food incident features and unique consumer characteristics, particularly their expectations of the food system, interacted to form each participant's individual trust response to the scenario. Consumer expectations were delineated into “fundamental” and “anticipatory” expectations. Whether fundamental and anticipatory expectations were in alignment was central to the trust response. Experiences with the food system and its actors during business as usual contributed to forming anticipatory expectations.Originality/valueTo ensure that food incidents do not undermine consumer trust in food systems, food system actors must not only demonstrate competent management of the incident but also prioritise trustworthiness during business as usual to ensure that anticipatory expectations held by consumers are positive.
Introducing a strategic perspective in lean thinking applications through system dynamics modelling: the dynamic Value Stream Map
Authors: Noto Guido , Cosenz Federico 
Published: September 2020

PurposeLean Thinking is an operation management discipline which aims to identify, map and analyse the activities forming a process to detect “value waste” and outline the most effective flow of activities to execute in sequence. Process mapping is often developed in lean projects through the use of the Value Stream Map (VSM). Like many other management tools, the VSM adopts a static and non-systemic perspective in the representation of an organizational process. This may result in the implementation of Lean projects inconsistent with the overall organizational long-term strategy, thus leading to dysfunctional performance. In order to overcome this limit, the paper suggests combining VSM with System Dynamics (SD) modelling.Design/methodology/approachThe paper is based on a review of the literature on VSM. This review is matched with an analysis of SD modelling principles aimed at explaining the practical and theoretical contribution of this approach to operation and strategic management practices. An illustrative case study is then provided to explore the practical implications of the proposed approach.FindingsOur results show that SD modelling provides robust methodological support to VSM and Lean Thinking due to its inner characteristics, namely: simulation, systemic view, explicit link between system structure and behaviour and effective visual representation.Originality/valueThis research proposes a novel approach to design VSMs aimed at fostering a strategic perspective in Lean Thinking applications. Such an approach connects two fields of research and practice – i.e. VSM and SD modelling – which have traditionally been kept separated or, at least, partially combined for specific organizational sub-systems, thereby neglecting a broader strategic view of the entire process system.
Commercial hard drive failures in a data center application and the role of SMART attribute information
Authors: Pecht Michael , Elburn Edmond 
Published: September 2020

PurposeThe reliability of hard disk drives (HDDs) is dependent on the drive construction, as well as the operational and environmental conditions, in which the drive is used. Self-monitoring, analysis and reporting technology (SMART) continuously provides attribute information on HDD usage and degradation characteristics.Design/methodology/approachThis paper aims to analyze the reported failures Backblaze data set for ST3000DM001 HDDs intended for desktop applications within a data center application. SMART attributes used for predicting failure are discussed and analyzed over the life of many hard drives. A case study on the actual use of SMART and the limitations of the SMART attribute information, the data center’s information and the use of desktop drives in a commercial application are also presented.FindingsThe analysis showed that when Backblaze started to record the data, the hard disk drives had already worked for a while with power on hours mean and standard deviation of 6,683 and 365 h, respectively. Therefore, it is possible that some SMART attributes have experienced critical values that have not been recorded by Backblaze. Additionally, 8% of all ST3000DM001 drives that Backblaze labeled as failed did not have raw values above zero for the five attributes that were considered critical. Backblaze recorded 25 SMART attributes in total for all hard disk drive brands where ST3000DM001 having 83.3% of the attributes ranked as the drive with the most attributes recorded. Having more recorded attributes with critical values leads to label more ST3000DM001 drives as failed while there might be the hard drives from the other brands or part numbers that experienced more critical SMART attributes but were not labeled as failed because of the lack of records.Originality/valueIt is an original work carried out at the Center for Advanced Life Cycle Engineering, University of Maryland.
Seeking sustainable futures in marketing and consumer research
Authors: Davies Iain , Oates Caroline J. , Tynan Caroline , Carrigan Marylyn , Casey Katherine , Heath Teresa , Henninger Claudia E. , Lichrou Maria , McDonagh Pierre , McDonald Seonaidh , McKechnie Sally , McLeay Fraser , O'Malley Lisa , Wells Victoria 
Published: September 2020

Purpose
Seeking ways towards a sustainable future is the most dominant socio-political challenge of our time. Marketing should have a crucial role to play in leading research and impact in sustainability, yet it is limited by relying on cognitive behavioural theories rooted in the 1970s, which have proved to have little bearing on actual behaviour. This paper aims to interrogate why marketing is failing to address the challenge of sustainability and identify alternative approaches.

Design/methodology/approach
The constraint in theoretical development contextualises the problem, followed by a focus on four key themes to promote theory development: developing sustainable people; models of alternative consumption; building towards sustainable marketplaces; and theoretical domains for the future. These themes were developed and refined during the 2018 Academy of Marketing workshop on seeking sustainable futures. MacInnis’s (2011) framework for conceptual contributions in marketing provides the narrative thread and structure.

Findings
The current state of play is explicated, combining the four themes and MacInnis’s framework to identify the failures and gaps in extant approaches to the field.

Research limitations/implications
This paper sets a new research agenda for the marketing discipline in quest for sustainable futures in marketing and consumer research.

Practical implications
Approaches are proposed which will allow the transformation of the dominant socio-economic systems towards a model capable of promoting a sustainable future.

Originality/value
The paper provides thought leadership in marketing and sustainability as befits the special issue, by moving beyond the description of the problem to making a conceptual contribution and setting a research agenda for the future.
Gaining insights into why professionals continue or abandon pro bono service
Authors: Patterson Paul G. , McColl-Kennedy Janet R. , Lee Jenny (Jiyeon) , Brady Michael K. 
Published: September 2020

Purpose
The purpose of this study is to empirically examine the personal/situational and business factors that encourage or discourage pro bono service of professionals based on the theory of institutional logics framework and the extended purchase behavior model.

Design/methodology/approach
This paper collected the data using a mixed-method approach: 30 qualitative interviews and 443 cross-sectional surveys from professional service providers across industries. The constructs of interest were measured with the scales compiled from the literature, industry reports and the preliminary interviews.

Findings
The results highlight emotional value derived from personal/situational factors (intrinsic motivation, personal recognition, philanthropic disposition and lack of appreciation) drove professionals’ intentions to continue to undertake pro bono work. While employer encouragement motivated professionals to engage in pro bono service, the prospect of gaining business opportunities and time constraints discouraged this important practice.

Research limitations/implications
While there has been considerable empirical study undertaken on charitable behavior, little attention has been given to this form of giving (pro bono work by service professionals). Overall, the results show that personal satisfaction with and feeling good about the study undertaken are required for continuation. Professionals who are intrinsically motivated, philanthropic-natured and properly-acknowledged through positive feedback and recognition tend to experience positive feelings that engender their good intentions to help the underprivileged, those in need and society more generally. The findings thus complement and extend the academic and industry literature on charitable giving.

Practical implications
This research identifies the drivers of service professionals’ continuation of pro bono work that the third sector relies heavily on its sustainability. As the study findings suggesting the importance of personal recognition, nonprofit organizations should demonstrate genuine gratitude and recognition of these professionals so that they continue to give their services pro bono.

Originality/value
The research is the first empirical study to develop a conceptual model that delineates the drivers and/or barriers to professionals continuing pro bono service. Unlike the previous study lacking a theoretical basis, this paper proposed and tested the conceptual model derived from the institutional logics framework and the extended purchase behavior model.
Review on state-of-the-art dynamic task allocation strategies for multiple-robot systems
Authors: N. Seenu , R.M. Kuppan Chetty , M.M. Ramya , Janardhanan Mukund Nilakantan 
Published: September 2020

PurposeThis paper aims to present a concise review on the variant state-of-the-art dynamic task allocation strategies. It presents a thorough discussion about the existing dynamic task allocation strategies mainly with respect to the problem application, constraints, objective functions and uncertainty handling methods.Design/methodology/approachThis paper briefs the introduction of multi-robot dynamic task allocation problem and discloses the challenges that exist in real-world dynamic task allocation problems. Numerous task allocation strategies are discussed in this paper, and it establishes the characteristics features between them in a qualitative manner. This paper also exhibits the existing research gaps and conducive future research directions in dynamic task allocation for multiple mobile robot systems.FindingsThis paper concerns the objective functions, robustness, task allocation time, completion time, and task reallocation feature for performance analysis of different task allocation strategies. It prescribes suitable real-world applications for variant task allocation strategies and identifies the challenges to be resolved in multi-robot task allocation strategies.Originality/valueThis paper provides a comprehensive review of dynamic task allocation strategies and incites the salient research directions to the researchers in multi-robot dynamic task allocation problems. This paper aims to summarize the latest approaches in the application of exploration problems.