bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal Associations of 12th-Grade Binge Drinking With Risky Driving and High-Risk Drinking
Authors: Vaca Federico E. , Li Kaigang , Luk Jeremy W. , Hingson Ralph W. , Haynie Denise L. , Simons-Morton Bruce G. 
Published: January 2020

OBJECTIVE:
To study the longitudinal associations of 12th-grade binge drinking with driving while impaired (DWI), riding with an impaired driver (RWI), blackouts, extreme binge drinking, and risky driving (self-reported Checkpoints Risky Driving Scale) among emerging adults up to 4 years after leaving high school.

METHODS:
The data were all 7 waves (W 1 to W 7 of the NEXT Generation Health Study; a US nationally representative study (N = 2785) with a probability cohort of 10th-graders (mean age = 16.2 years; SE = 0.03) starting in the 2009–2010 year. Binary and ordinal logistic regressions were used for the analysis.

RESULTS:
Binge drinking prevalence in W1 to W3 was 27.2%, 23.8%, and 26.8%, respectively. Twelfth-grade binge drinking was associated with a higher likelihood of DWI, RWI, blackouts, and risky driving in W4 to W7 and extreme binge drinking in W7. Adolescents who binged ≥3 times in high school were more likely to DWI, RWI, blackout (W4 to W7), be involved in extreme binge drinking (W7), and report riskier driving several years after high school. In some waves, parental practices appeared to have enduring effects in protecting against DWI, RWI, and blackouts.

CONCLUSIONS:
Twelfth-grade binge drinking is a robust predictor of early adulthood DWI, RWI, blackout, extreme binge drinking, and risky driving. Our study suggests that ongoing parental practices could be protective against DWI, RWI, and blackouts once adolescents transition from high school into early adulthood. Prevention programs that incorporate binge drinking–focused screening and bolster parental practices may reduce the likelihood of later major alcohol-related health-risk behaviors and consequences in emerging adults.
Tek Bir Seansta Zirve Oksijen Kullanım Düzeyini Veren En Yüksek Güç Çıktısını Tahmin Etmenin Basit Bir Yöntemi
Authors: ÖZKAYA Özgür , BALCI Görkem Aybars , AS Hakan , ÇABUK Refik , NOROUZİ Mahdi 
Published: January 2020

Zirve
O2 tüketim düzeyi ( VO2pik) veren en yüksek güç çıktısı (aerobik limit güç; ALG)
şiddetli ve aşırı egzersiz alanlarını ayıran önemli bir eşiktir ve sporcularda
bireysel bir ALG belirleyebilmek için çok sayıda sabit yüklü tüketici test
yapmak gerekmektedir. Bu çalışmanın amacı; sporcuların ALG’lerini tek bir
seansta belirleyebilecek bir yaklaşım önermektir. Araştırmaya iyi antrene 12
bisiklet sporcusu katılmıştır ( VO2maks64,7±4,2 mL∙dk-1∙kg-1; Zirve
Güç (ZG): 374,1±65,7 W).VO2pik düzeyinin belirlenmesi için lineer yük artışlı (ramp)
testler uygulatılmıştır (+1 W·2 s-1) ve protokollerin sonunda
ulaşılan final güç üretim değerleri (FG) ortalama yanıt zamanı (mean response time: MRT) düzeltmesi uygulanmadan (FGMRT) ve uygulanarak
(FGMRT) değerlendirilmiştir. Sporcuların VO2maks’ı ve bu değeri veren ZG değerleri, doğrulama testleri
uygulanarak bulunmuştur. Devamında sporcuların ALG (VO2maks’a %5’ten daha yakın VO2 değeri veren en yüksek güç çıktısı) değerleri, 15 W’lık
intervallerle bitkinlikle sonlanan sabit yüklü testler yoluyla ayrı günlerde
taranmıştır. FGMRT ile ALG değerleri arasındaki fark anlamlı
değildir (FGMRT: 435,2±50,8; ALG: 435,4±62,5 W, p=0,968).
Bland-Altman sonuçları yüksek uyum göstermiştir (Bias=0,20±17,6 W; p=0,968). FGMRT,
gerçek ZG’nin %117,5±8,8’ine karşılık gelirken, belirlenen ALG değeri ZG’nin
%117,1±7,37’sine karşılık gelmiştir (p=0,759). Diğer yandan ramp testinden elde
edilen en yüksek 15-s VO2 ortalamaları da ALG yükündeki VO2 yanıtlarıyla benzerdir ( Ramp Test: 62,3±4,9 ml∙dk-1∙kg-1,
%96,2; ALG: 61,5±4,3 ml∙dk-1∙kg-1, %95; p=0,119 ). Sonuç
olarak, ALG’yi belirleyebilmek için ayrı günlerde çok sayıda bitkinlikle
sonlanan test yapmak yerine, tek seansta bir ramp test uygulamasının VO2maks’ı düşük tahmin ettiği ancak ALG’yi ve bu değere
karşılık gelen VO2 yanıtını belirleyebilmenin oldukça pratik bir yöntemi
olabileceği bulunmuştur.
Toxicity of the macerated of white and purple jurubeba flowers about bees Apismelliferas in sertao paraibano - Brazil
Authors: Ferreira Allan Martins , Medeiros Aline Carla de , Dantas Jussara Silva , Ventura Rosy Carina de Araujo , Japiassu Andre , Martins Edmara da Nóbrega Xavier , Maracaja Patricio Borges 
Published: January 2020

There are secondary components of the nectar or the pollen in some vegetal species, to can be toxics or repellentsfor their pollinators. Thus, this work had for objective to study the effects from toxicity of differents concentrationsof macerated flowers of purpleJurubebaandwhite Jurubeba, as feeding of Africanized bees in a controlled environment.Therefore, wererealizedbioassays at the Laboratory of Entomology of the Federal University of Campina Grande, Campus ofPombal.It was used dried and crushed flowers of the Chamber and leaddy. The powder of the flowers was weighed in three different fractions (0,25%, 0,50% e 1,0%) and added to the candyandwater. The newly emerged workers were distributed togetherof 20 insects for wood boxmeasuring 11cm in length by 11cm in width and 7cm in height, in three replicates and control, making up 12 boxes and 240 worker bees, were packaged in B. O. D with temperature adjusted to 32º C andhumidity of 70 %. The control group received only candy and water. In view of the results obtained with the research, observed that the bees of the control remained alive until the 25 days reaching a statistical average of 20 days and for those treated with 0,25%, 0,50% e 1,0% respectively, presented mortality in the 20th, 18th e 13th day for bees fed with Solanum paniculatum L.For bees fed Solanum albidum Dun, observed that the bees of the control remain alive up to the 21 days reaching a statistical average of 18 days and for those treated with 0,25%, 0,50% and 1,0% respectively, presented mortality in the 17th, 13th e 12th day.The data analysis showed statistically significant differences between treatments and control, suggesting the toxic effect of the macerate obtained from Solanum paniculatum LandSolanum albidum Dunfor Africanized bees workersApismellifera. Thus, can be concluded with the accomplishment of this work that:The bees control remained alive until the 25thand 21th dayrespectively, by treatments with Solanum paniculatum L.andSolanum albidum Dun; The treated beeswith the concentrations 0,25%, 0,50% and 1,0% of macerated flowers Solanum paniculatum L, respectively, presented mortality to the 20th, 18thand 13thday; The treated bees with the concentrations 0,25%, 0,50% and 1,0% of macerated flowers Solanum albidum Dun, respectively, presented mortality to the 17th, 13thand 12th day; Flowers of Solanum paniculatum L. andSolanum albidum Dunpresented toxicity to Apismelíferaunder controlled ambient conditions
Use of Four-Color Flow Cytometric Assay for Discrimination of Hematogone from Lymphoblast: Critical Issue for MRD Assessment in B-ALL Patients
Authors: Allahbakhshian Farsani Mehdi , Shahabi Satlsar Esmaeil , Mohseni Alireza , Mosleh Mohammad , Mehrpouri Mahdieh , Agaeipour Mahnaz , Mohammadi Mohammad Hossein , Gholampour Roohollah , Jadali Farzaneh 
Published: January 2020

Background: Hematogones are normal B-cell precursor which can be seen in different physiological and pathological conditions. Due to variation in B-cell acute lymphoblastic leukemia (B-ALL) blasts immunophenotyping and interference of hematogones in minimal residual disease (MRD) assessment, precise discrimination of hematogones is very crucial. The purpose of this study was to evaluate the expression pattern of surface markers in hematogones and compare them with lymphoblasts.
Material and Methods: In this applied study, flow cytometric analysis was performed using Coulter FC-500 and MXP software in 4-color combination and 6 different tubes. In this study, 85 patients diagnosed with acute lymphoblastic leukemia were evaluated. Out of these patients, 45 were boys and 40 were girls. Patients aged from 1 to 15 years old. In addition, 27 bone marrow samples from other patients aged 4 to 18 years were included in this investigation. These samples had been obtained for other diagnostic purposes, such as immune thrombocytopenic purpura and juvenile idiopathic arthritis.
Results: During flow cytometric analysis, hematogones showed expressions of CD19, CD20, CD22, CD10, CD45, CD81, CD123, CD9, CD34 (partial expression), and tdt (partial expression). In these patients, hematgones were negative for CD66c expression. Lymphoblastic cells were positive for CD19, CD20 (in some cases), CD22, CD10, CD45, CD81, CD123, CD58, CD9, CD66c, CD34 (in most cases), and TDT. CD81 mean fluorescence intensity (MFI) in hematogones was higher than that in lymphoblasts. (112.5 (30-251) vs. 17.5 (5-30); P<0.0001)
Conclusion: According to findings of this study, it seems that the use of CD81, CD58, CD123, CD66c, CD9, and CD81 MFI in combination with B-Cells associated markers can be very effective in differentiating hematogone from lymphoblast.
Radiosensitivitas Kalus Embriogenik Kopi Robusta Bp 436 Terhadap Iradiasi Sinar Gamma
Authors: Ibrahim Meynarti Sari Dewi , Randriani Enny , Sari Laela , Nuraini Anne 
Published: January 2020

<p><em>High genetic diversity is one factor that determines the success of plant breeding. Mutation induction by gamma ray irradiation is one method to improve plant genetic diversity. This study aimed to 1) obtain growth regulators composition suitable in inducing embryogenic callus, 2) determine the effect of gamma ray irradiation on the growth and development of somatic embryos, and 3) obtain lethal dose (LD) <sub>20</sub> and <sub>50</sub> values in Robusta coffee BP 436. The study was conducted at the Tissue Culture Laboratory, Industrial and Beverage Crops Research Institute, from May 2017 to December 2018. Explants used were young leaves of Robusta coffee BP 436. Callus induction used ½ MS media with 2,4-D (4.52 μM) and 2-iP (0.00; 4.93; 9.86; 14.79; and 19.72 μM) treatment. Mutation induction was performed using gamma radiation dosed at 0, 10, 20, 30, 40, and 50 Gy treatments. The regeneration media was ½ MS containing GA<sub>3</sub> (0 and 1 mg/l). The study used a complete randomized design with 10 replications. The results showed the best combination of plant growth regulator to induce the callus was 2.4-D 4.52 μM + 2-iP 19.72 μM. The fresh weight of cultures was inhibited above 30 Gy, whereas the number of somatic embryos decreased at doses above 10 Gy. Addition of GA<sub>3</sub> 1 mg/l in regeneration media increased the number of somatic embryos in torpedo phase, but not in gamma irradiation exposed calluses. The LD<sub>20</sub> and LD<sub>50</sub> of Robusta coffee BP 436 are 16.81 and 28.52 Gy, respectively.</em></p>
A randomised controlled trial of an educational intervention to promote Oral and dental health of Patients with Type 2 Diabetes Mellitus
Authors: Mallekmahmoodi Maryam , Shamsi Mohsen , Roozbahani Nasrin , Moradzadeh Rahmatalah 
Published: January 2020

Abstract
Background: Diabetes is the most prevalent disease resulted from metabolic disorders. This study aimed to investigate the effect of training based on health belief model (HBM) on oral hygiene-related behaviors in patients with type 2 diabetes mellitus.
Methods: This study was conducted as an educational randomized controlled trial (single blind) on 120 patients with type 2 diabetes referring to a diabetes clinic selected through systematic sampling, who were assigned to two groups of control (N=60) and intervention (N=60). The data collection tool was a valid and reliable questionnaire based on (HBM) which was completed for both groups before the intervention. Then, the intervention group received 4 sessions of training based on health belief model in one month, and the same questionnaire was completed again after 3 months and data were analyzed using SPSS 20 applying the t-test, paired t-tests, Chi square, Mann-whitney test and Wilcoxon test analysis. The significance level was considered at 0.05.
Results: Three months after the intervention, awareness of the patients and perceived susceptibility, benefits, self-efficacy, internal cue to action and performance in oral and dental hygiene-related behaviors had a significant increase in the intervention group (p<0.05). So that before the intervention, the mean performance score of the intervention and control groups were
2.16±0.71 and 2.28±0.76, respectively, and no significant difference was observed (p> 0.05). However, after the intervention, the mean performance score of the intervention group (3.25±0.49) was significantly more than that of the control group (2.66 ±0.56) (p = 0.001).
Conclusion: Our results suggested that the training the patients with diabetes based on HBM and performing active follow-ups can enhance their skills in the field of oral and dental hygiene-related behaviors. Also, control, monitoring and training follow-up is recommended during these programs.
Assessment of Knowledge, Attitude and Practice towards rabies and associated factors among household heads in Mekelle city, Ethiopia
Authors: Hagos Weldegerima Gebremedhin , Muchie Kindie Fentahun , Gebru Goyitom Gebremedhn , Mezgebe Gebreamlak Gebremariam , Reda Kebede Ambaye , Dachew Berihun Assefa 
Published: January 2020

Abstract
Background: Rabies has a worldwide distribution in continental regions of Africa, Asia and the Latin America. Globally, the case fatality rate is 100% once a clinical sign is developed. Poor public awareness towards rabies is one of the major obstacles in any prevention and control scheme of the diseases. The study aimed to assess knowledge, attitude and practice (KAP) about rabies and associated factors among household heads in Mekelle city, Northern Ethiopia, 2016.
Methods: A community based cross-sectional study was conducted from October to November 2016 with a total of 633 study participants. Data were collected using a pretested structured questionnaire and entered to EPI-Info 3.5.4 and coded, cleaned and analyzed using SPSS version 20 software. Bi variable and multivariable analysis was done to identify factors associated with knowledge, attitude and practice about rabies. Variables having p< 0.05 was considered as statistically significant at 95%CI.
Results: Of 633 study participants, 357 (56.4%) were females and 239 (37.8%) were 18-35 years old. Among the study participants, 56.1% (95%CI=52.2, 59.9), 56.2% (95%CI=52.4, 60.1) and 61.3% (95%CI=57.5, 65.1) had good level of knowledge, attitude and practice on the prevention and control of rabies respectively. Being female (AOR=1.50, 95%CI=1.05, 2.13), dog owner (AOR=1.68, 95%CI=1.17, 2.41) and participants who had training on rabies (AOR=2.22, 95%CI=1.53, 3.21) were found to have good knowledge. Married participants (AOR=2.19, 95%CI=1.16, 4.16), participants who owned dog (AOR=2.64, 95%CI=1.80, 3.86) and those encountered dog bite (AOR=2.24, 95%CI=1.23, 4.10) were found to have positive attitude towards rabies. Similarly, dog ownership (AOR=11.85, 95%CI=7.16, 19.6) was found to be associated with good practice.
Conclusion: This study showed that more than half of the respondents had good knowledge, attitude and practice about the prevention and control of rabies.
Key words: Attitude, Knowledge, Practice, House hold, Rabies
Evaluating the myopia progression control efficacy of defocus incorporated multiple segments (DIMS) lenses and Apollo progressive addition spectacle lenses (PALs) in 6- to 12-year-old children: study protocol for a prospective, multicenter, randomized controlled trial
Authors: Li Yan , Fu Yafei , Wang Kai , Liu Zhiming , Shi Xiaoqing , Zhao Mingwei 
Published: January 2020

Abstract
Background: Myopia is increasing in prevalence and is currently recognized as a significant public health issue worldwide, particularly in China. Once myopia develops, appropriate clinical interventions need to be prescribed to slow its progression. Currently, several evidences indicate that myopic defocus (MD) retards eye growth and myopia progression. However, no clinical trials have compared the outcomes of different MD spectacle lenses in the same observational group, especially in mainland China. The aim of the present study is to compare the myopia control efficiency of two different MD spectacle lenses, i.e., defocus incorporated multiple segments (DIMS) lenses and Apollo progressive addition spectacle lenses (PALs).
Methods: The trial is designed as a 3-year, prospective, randomized, multicenter clinical trial of school children treated with DIMS lenses and PALs. A total of 600 Chinese primary school children aged 6-12 years will be recruited, and each group is intended to include 300 subjects. The inclusion criteria are myopia between −1.00 and −5.00 D and astigmatism ≤1.50 D. The follow-up time points will be 1 month (m), 3 m, 6 m, 12 m, 18 m, 24 m, 30 m, and 36 m. The primary outcome will be determined by the difference in cycloplegic spherical equivalent refraction (SER) between baseline and the last follow-up visit between the two groups. The secondary outcome is the axial length, and the exploratory outcomes include ocular biometric measures, peripheral refraction, binocular vision, accommodation, compliance and the results of questionnaires related to wearing experiences.
Discussion: The present study will be the first randomized controlled trial in primary school myopic children with the treatment of DIMS lenses and PALs in China. The results will indicate whether and how much different MD mechanisms retards myopia progression and axial elongation. In addition, the comparison will provide information on the clinical efficacy and safety of DIMS lenses and PALs, including information related to wearing experiences and visual functions
Effects of Date Fruit (Phoenix Dactylifera L.) on Labor and Delivery Outcomes: A Systematic Review and Meta-Analysis
Authors: Karimi Alireza Bagherzadeh , Elmi Asghar , Mirghafourvand Mojgan , Navid Roghyeh Baghervand 
Published: January 2020

Abstract
Background: The rate of cesarean section is increasing in all over the world with different drafts in various countries. This growth increases unpleasant outcomes of delivery. Recent studies explained the benefits of date palm fruit on labor process improvement. Date fruit can be considered as a factor for increasing vaginal delivery and also reducing the frequency of caesarean section in order to prevent its great complications. This systematic review has been designed to review clinical studies that investigate the effects of date palm fruit on labor outcomes (duration of labor stages, bishop score, and frequency of cesarean section) compared with routine cares.
Methods: This study was performed in 2019. Required data has been collected from electronic databases and manual searches. All clinical trials evaluating the effects of date palm fruit on labor and delivery that were published from January 2000 to August 2019 in English and Persian languages, were incorporated in this systematic review. The methodological quality of the included studies was evaluated according to the risk of bias assessment of Cochrane handbook of systematic reviews, and were then reported using Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement.
Results: Nine studies were included in the qualitative and quantitative synthesis. Meta-Analysis showed that date fruit consumption can significantly reduce active phase of labor (three trials with 380 participants; (MD= -109.3, 95%CI (-196.32, -22.29; I2=89%), P=0.01), and also it can significantly improve the bishop score (two trials with 320 participants; MD = 2.45, 95%CI (1.87, 3.04; I2=0%), P<0.00001). Date fruit consumption had no effects on the duration of first, second, and third stages of labor, and the frequency of cesarean section.
Conclusion: Date can reduce the duration of active phase and improve the bishop score; however, due to from the low to mediate quality of the studies; it seems that the other studies are needed to prove these results better than this.
Key words: Date Palm, Date fruit, Phoenix dactiylifera, Delivery, Labor, Systematic review, Meta-analysis.
Whole genome resequencing of the Iranian native dogs and wolves to unravel variome during dog domestication
Authors: Ghanatsaman Zeinab Amiri , Wang Guo-Dong , Nanaei Hojjat Asadollahpour , Fozi Masood Asadi , Peng Min-Sheng , Esmailizadeh Ali , Zhang Ya-Ping 
Published: January 2020

Abstract
Background
Advances in genome technology have simplified a new comprehension of the genetic and historical processes crucial to rapid phenotypic evolution under domestication. To get new insight into the genetic basis of the dog domestication process, we conducted whole-genome sequence analysis of three wolves and three dogs from Iran which covers the eastern part of the Fertile Crescent located in Southwest Asia where the independent domestication of most of the plants and animals has been documented and also high haplotype sharing between wolves and dog breeds has been reported.
Results
Higher diversity was found within the wolf genome compared with the dog genome. A total of 12.45 million SNPs were detected in all individuals (10.45 and 7.82 million SNPs were identified for all the studied wolves and dogs, respectively) and a total of 3.49 million small Indels were detected in all individuals (3.11 and 2.24 million small Indels were identified for all the studied wolves and dogs, respectively). A total of 10,571 copy number variation regions (CNVRs) were detected across the 6 individual genomes, covering 154.65 Mb, or 6.41%, of the reference genome (canFam3.1). Further analysis showed that the distribution of deleterious variants in the dog genome is higher than the wolf genome. Also, annotation of genomic variations showed that the proportion of genomic variations in the intron and intergenic regions in the wolf genome is higher than that in the dog genome, while the proportion of the coding sequences and 3'-UTR in the dog genome is higher than that in the wolf genome. The genes related to the olfactory and immune systems were enriched in the set of the structural variants (SVs) identified in this work. Generally, genes engaged in digestion and metabolism and neurological process had an important role in the process of dog domestication.
Conclusions
Our results showed more deleterious mutations and coding sequence variants in the domestic dog genome than those in wolf genome. By providing the first Iranian dog and wolf variome map, our findings contribute to understanding the genetic architecture of the dog domestication.