bluuebunny/crossref_metadata_2025_split huggingface dataset:
ELEMEN ARSITEKTUR, INTERIOR DAN SIGNAGE UNTUK MENEMUKAN JALAN DAN BRANDING UNIVERSITAS KRISTEN PETRA
Authors: Tanuwidjaja Gunawan , Wijaya Nerissa Arviana , Widyanto Lavenia , Wiarta Stephanie Seaver , Sugianto John Kenley 
Published: June 2020

Title: Architectural, Interior Elements and Signage for Wayfinding and Branding in Petra Christian University
Petra Christian University (PCU) is a leading private University in Surabaya. PCU possessed advantage in facility?s quality as well as educational service. This was clearly visible in the campus building design that played as architecture, interior and graphic wayfinding elements, especially in W Building (Radius Prawiro Building), EH Building (Entrance Hall) and T Building. Further these elements could also support the University?s Branding and were integrated in the PCU?s integrated wayfinding system.
PERAN PEREMPUAN DALAM MERUMAH
Authors: Koniherawati  , Pratikno Priyo 
Published: June 2020

Title: The Roles of Wemen in Domestic Activities
Women, especially mother, has a major role in build and maintain a home, as shown by various ethnic groups in the world. The various roles of woman indicated in protection, give a sense of comfort, and safety for the baby and all family member. Mother is person who gives a shade of home through food processing activities and how to primp her self. The efforts collecting building materials, to decorate, and chose home furnishings are dominant activities that mother does. This study is explore the problems of designing of home by women in the past were intended to justify the design of art and architecture. This study based on literature that shows the role of the mother in build, manage, and interpreting a house. The method of this study base on secondary data and then weave every aspects to build the hypotheses. These information show that women as housewives have a significant role in shaping the house as culturally or physically. The results showed that women as mother very dominant in giving the feel and shape of house.
PENINGKATAN VISIBILITAS BANGUNAN LAMA, STUDI KASUS JALAN KREMBANGAN BARAT SURABAYA
Authors: Nugroho Setyo 
Published: June 2020

Title: The Improvement of Old Building Visibility, Krembangan Barat Street of Surabaya as of Case Study
High development in the City center forces old building losing its existence. The main factor old buildings losing its existences are the lack of skyline guideline (new buildings obstruct the view toward old buildings), the changes of traffic direction, and the selection of vegetation type. This paper discusses a brief evaluation of old building visibility through visual experiences, and gives a schematic design as proposal for jalan Krembangan Barat. Serial vision technique analysis is addressed in order to gain the visual and spatial experiences of the built environment. Result shows that three spots of place should be improved in order to perceive the visibility by rehabilitating, adaptive re-using, and providing pedestrian ways to connect one potential spot to others in the corridor of Krembangan Barat.
KINERJA TERMAL RUMAH NIANG DI DATARAN TINGGI TROPIS LEMBAB DI DISTRIK MANGGARAI
Authors: Alfred D.D. P. Jhon , Antaryama I Gusti Ngurah , N.E. Sri Nastiti 
Published: June 2020

Title: The Performance of Niang House in the Tropical Highland of Manggarai District
Niang home is one of the ten varieties of Traditional Architecture in East Nusa Tenggara Province located in the highlands of Manggarai district (800 - 1200 meters above sea level) with its peculiarities, namely the circular floor plan and a conical roof. Niang home is growth by people with all kinds of traditions and utilize a variety of local potentials such as materials, technology and knowledge. But local potentials such as the use of lightweight materials such problems occur in upland areas that tend to be cold because the thermal properties of lightweight material is loose and flowing out so that it can potentially create underheating and conditions affecting comfort conditions in buildings. This study aimed to evaluate the effect of house design of Niang in response to thermal conditions in the highlands and analyze the behaviour of the material of the design elements that affect the thermal performance of the house of Niang. The study was conducted by the method of observation and simulation with the help of software ARCHIPAK version 5.0. The final results of this study indicate that the design of Niang house can not provide adequate thermal comfort, especially at night until morning, where the condition of the buildings tend to underheating in considerable period of time. From the simulation can also be seen that the floor and the roof is the most critical element of the heat release.
PENELUSURAN KAWASAN ALUN-ALUN BUNDER KOTA MALANG SEBAGAI OPEN SPACE RANCANGAN IR KARSTEN
Authors: Putra R. Dimas Widya 
Published: June 2020

Title: Searching of Alun-Alun Bunder District in Malang City as Open Space which was Built by Ir Karsten
Alun-Alun Bunder plays an important role for city of Malang development during Dutch collonialism. Alun-Alun Bunder was the policy for expanding the second city (Bouwplan II) which had the total size of 15.547 M2. the reason of Alun–Alun Bunder designing was to establish the new administration pivot, this main reason became the basis for the governance at that time (Gemeente) to design the second city expansion (Bouwplan II). This district was named as Gouverneur-Generaalbuurt. The design was realized in 1922. In subsequent, this area was known as „Alun-Alun Bunder”. The research purpose are to know the development pattern of Alun-Alun Bunder, identification of landscape function as the landmark which use as interaction space. Analysis technique which is used in this research, consist of ; diachronic reading, descriptive- evaluation related by linkage pattern and synchronic reading. The result shown that Alun-Alun Bunder is the best city hall model which was desired by Dutch government. The infrastructure, among them are; settlement, education and transportation are designed to follow the role of Alun- Alun Bunder as the core of Dutch administration. The strategy to strengthen the historical value in Alun-Alun Bunder is gained by strengthening the linkage towards historic object which exist inside.
PEMBERDAYAAN LOKALITAS DAN KREATIVITAS: UPAYA MENUJU BANDUNG KOTA KREATIF
Authors: Rahayu Tri , Sugiarto Roni 
Published: June 2020

Title: Empowerment of Locality and Creativity: The Effect towards Bandung Creative City
As modernity with all rigidity and practically increasingly creeping, the locality was still elegant with its charm. Localities seems to be a special allure which become healer of longing of the past. Everything related to tradition inspires architects and city planners. Creative design certainly has allure for residents, local and non local tourists. Bandung is the city wellknown as Paris Van Java, which has consequence to the arrangement of the infrastucture and face of the city with strong identity of exquisite Sundanese culture. These opportunities would require creativity which offer uniqueness and special identity of Bandung. The study of city arrangement, planning stategy towards creative city, and sustainable strategy would be essential to realize the Bandung Creative City. The study was conducted by observing Bandung infrastucture at some central points in the heritage building until face of the city, and how the goverment‘s strategy to overcome this problem, related to creativity. The result shows that efforts to Bandung Creative City is done through empowerment of ?creative economy‘ in fashion, culinary, and design decorate city faces up to hilly region. Creative city allows the achivement of community prosperity and economically independence. Furthermore, through ?Bandung Creative City‘ program, the impact is not only to the creative city but also to a ‘smart city‘ which is done the following strategies: innovation, decentralization, and collaboration.
PENGEMBANGAN KAWASAN PERMUKIMAN SUBURBAN BERBASIS TRANSIT ORIENTED DEVELOPMENT (TOD)
Authors: Octarino Christian Nindyaputra 
Published: June 2020

Title: The Development of Suburb Residential Area Based on Transit Oriented Development (TOD)
The rapid growth and development of the city has impacted on the increasing of city population and traffic density which lead to various urban problems. The development of suburbs as a satellite city is considered as an appropriate solution to reduce the main city‘s load. This area could be developed into residential uses to provide living area for commuters. The railway that connects Solo and Wonogiri is considered as a major potential to create the integration between Solo as the main city and other areas as regional supports. Pasar Nguter Station is located on the route of Solo-Wonogiri railway and has great potential. The aim of this research is to examine and explore possibilities of Pasar Nguter Station to be developed as residential area based on Transit Oriented Development (TOD). This research will assess the existing condition surrounds Pasar Nguter Station based on the principal aspects of TOD such as mobility, land use, intermodal network, etc. to analyze the gap between existing and ideal conditions to formulate the most appropriate regional development strategy.
KAJIAN PANOPTISISME DAN ARSITEKTUR KONTROL DALAM PERATURAN PEMBANGUNAN GEREJA KATOLIK
Authors: De Yong Sherly 
Published: June 2020

Title: Exploration of Panopticism and Architecture of Control in Building Guidance for Catholic Church
Michel Foucault introduces a mechanism to increase surveillance powers through architectural arrangement, referred to as panopticism. The connection between control of architecture and panopticismin the Catholic church is the main problem of this research. The purpose of this study is to determine the panopticism in architectural field, examine the relationship between principles of panopticism with architectural theory, especially the theory of the architecture of control, to produce a benchmark that can be used to analize the regulation in Catholic church. Through descriptive analysis and critique interpretive method, the results obtained are that panopticon and panopticism are also part of the architecture of control. From the theory of panopticon, there are six elements of panopticism can be derived (segmenting, grouping, control activities, orientation, hierarchy and control system); the most influential element in the architecture is the element of Control System. To analyze the church, we are using normative and interpretive criticism methods. The results is that the Catholic church has a system of controlling and regulating the discipline panopticism (especially panopticism supervision from the supervised vision) using the general guidance of Roman Missale as the catholic standard rules.
MEMAHAMI INTERIOR SEBAGAI PENGHUBUNG
Authors: Thamrin Diana 
Published: June 2020

Title: Understanding Interior as a Connector
Interior design is a discipline that is very close to the complexities and the needs of human life. However, the intepretation and practice of interior design are often limited to decoration and contents within the physical boundaries of architecture. This paper aims to provide another perspective regarding the concept of interior that is, as a significant connector between humans and their living environment along with architecture, so that the methods and practice of interior design as well as architecture may expand more than what has been observed today. The paper is a result of a qualitative research through literature review and exploration of case studies. Results conclude to several interior and architectural design techniques based on the perception of interior as a ?connector? that could be used, such as the blurring of physical boundaries, programmatic manipulation, innovation of material continuity and configuration of architectural elements into interior elements. Through the physical as well as conceptual manipulation of space, the intepretation of interior design would no longer be limited to the contents within the physical boundaries of architecture but rather a truly important connector along with architecture, between humans and their living environment.
PENGETAHUAN DASAR DESAIN TIGA DIMENSI SEBAGAI CARA MAHASISWA DESAIN UNTUK BERPIKIR BENTUK RUANG DAN VOLUME
Authors: Putro R. Tosan Tri 
Published: June 2020

Title: Three Dimensional Basic Design Knowledge as Thinking Tools for Understanding the Shape, Space and Volume
The consciousness of observing the shape and space of an object, whether large or small, is the sensitivity that becomes a designer of three-dimensional objects. A product form is created with full awareness by the designer, not by itself appearing. In addition to the function of the design object, in a design process there is a styling stage, aesthetic value visually, a form that follows the function or shape that follows the material. Aesthetic value in a design product that can not be separated from the ability of the designer with visual experience. The ability and sensitivity to observe and create an aesthetic visual form should be instilled since someone declares himself to be a designer or planner. Design areas such as architecture, interior, urban design, area and also design product are demanded for their ability to sensitize observing and design a space, volume and shape. This study is based on observations on a group of design students and literature studies. Based on observations over time, the spatial thinking capacity of each person is different, as is the ability to create an aesthetic value in a design. Everyone has different absorbtive power and creativity.
PENGARUH GAYA KOLONIAL BELANDA PADA INTERIOR RUMAH TINGGAL DI KAYUTANGAN MALANG
Authors: Setiati Grace 
Published: June 2020

Title : The Influence of Dutch Colonial Style on Design Residential in Kayutangan Malang
Malang is referred to as one of the best products of colonial town planning in the Dutch East Indies. The city center of Malang in 1914 is located in the Kayutangan to Malang town square. Region Kayutangan a commercial area of Malang in the Dutch colonial occupation. Influence of development of Dutch colonial architecture included in the settlement of indigenous people, so with Kayutangan. This study aims to assess the legacy of Dutch colonial style design of houses in the area Kayutangan Malang. The research method using descriptive qualitative method with case studies. Research result shows there are significant design style colonial with the adaptation of local materials and adapted to the tropical climate in the city of Malang, there is also a mixing effects of European culture, Chinese traditional culture and the Java community. Colonial design style is manifested in the physical building with simplification of forms, according to ability, interpretation and technologies currently owned and maintained until now.
PELESTARIAN ARSITEKTUR MUSEUM SONOBUDOYO YOGYAKARTA
Authors: Handayani Titi 
Published: June 2020

Title: Architectural Conservation of Sonobudoyo Museum, Yogyakarta
Sonobudoyo Museum has been experiencing many changes. More activities and collections have caused to the increasing number of rooms and new buildings. The problem is that the new building design is not suitable with the original building design and lay out by the Dutch architect, Thomas Karsten. It leads to the decreasing of the quality of the environment, even decreasing the cultural values of the museum as a heritage building. The aim of the research is to study the existing condition of Sonobudoyo Museum in order to understand changes of the original design. Evaluation of all buildings in Sonobudoyo Museum focused on their functions. Method used in this study is descriptive-qualitative. Data and findings of field surveys were analyzed in order to find the architectural characteristics of the museum and its changes. There are four conservation actions to be recommended, which are (1) preservation of buildings as their original design, (2) repairation and restoration buildings, (3) demolition of unapropriate buildings, and (4) location of new buildings.
NILAI KENUSANTARAAN ARSITEKTUR BOLA UGI MENURUT SANRO BOLA DI DUSUN KAJUARA KABUPATEN BONE
Authors: Hamka  
Published: June 2020

Title: Nusantara Value of Architecture of Bola Ugi at Kajuara Village, Bone District, According to Sanro Bola
Nusantara Architecture has been apprehended as an archipelagic vernacular architecture located in the locality of cultural space. It has a tacit knowled related to traditions, values, as well as a universal and sectional significance (Pangarsa, 2006). The cultural characteristics of Nusantara architecture in Indonesia has a diverse forms, both physical and non-physical. One of archipelagic vernacular architectures in the cultural space is bola ugi architecture (Buginese House). Bola ugi has archipelagic elements associated with the values and space and physical significance. The purpose of this study was to determine the archipelagic values in bola ugi based on the knowledge possessed by the House of Bugis architect sanro bola. This research used a descriptive analysis qualitative research methodologies based on interviews of some sanro bolas and was conducted using a snow ball sampling. The results of the research showed that the archipelagic value of bola ugi included the hierarchical elements of space, room layout, orientation, and the symbol of the structure.
Ética y consulta previa
Authors: Figueroa Isabela 
Published: June 2020

En julio del 2018 la Universidad del Magdalena (Santa Marta, Colombia) puso en funcionamiento el Comité de Ética en Investigación. Ese Comité queda encargado de “evaluar, conceptuar y dar seguimiento, desde el punto de vista ético, a los proyectos de investigación que presente y desarrolle la Universidad, cuando en su objeto o método se intervenga con la salud o la vida (humana o no humana), o con el medio ambiente o la biodiversidad.” Entre sus funciones, está la de garantizar que los proyectos de investigación respeten a las personas y comunidades participantes de los proyectos.
El semestre pasado el Comité de Ética analizó un proyecto de investigación elaborado por mí, en calidad de docente investigadora de la Unimagdalena. El proyecto pretende identificar de qué manera la Corte Constitucional de Colombia reconoce (o no) derechos territoriales de los pueblos indígenas sobre porciones del mar. Como método de trabajo, fueron previstas dos entrevistas grupo-focal en dos comunidades pesqueras wayúu en la provincia de la Guajira. Las autoridades comunales de ambas comunidades tienen conocimiento de esa propuesta de investigación, que fue elaborada en diálogo con sus líderes. El proyecto presentado incluyó los formatos de consentimiento previo e informado a ser firmado por cada participante del grupo focal, con el previo consentimiento de sus autoridades tradicionales.
PTML Modeling for Alzheimer’s Disease: Design and Prediction of Virtual Multi-Target Inhibitors of GSK3B, HDAC1, and HDAC6
Authors: Kleandrova Valeria V. , Speck-Planche Alejandro 
Published: June 2020

Background:
Alzheimer’s disease is characterized by a progressive pattern of cognitive and
functional impairment, which ultimately leads to death. Computational approaches have played an important
role in the context of drug discovery for anti-Alzheimer's therapies. However, most of the computational
models reported to date have been focused on only one protein associated with Alzheimer's,
while relying on small datasets of structurally related molecules.

Objective:
We introduce the first model combining perturbation theory and machine learning based on
artificial neural networks (PTML-ANN) for simultaneous prediction and design of inhibitors of three
Alzheimer’s disease-related proteins, namely glycogen synthase kinase 3 beta (GSK3B), histone deacetylase
1 (HDAC1), and histone deacetylase 6 (HDAC6).

Methods:
The PTML-ANN model was obtained from a dataset retrieved from ChEMBL, and it relied on
a classification approach to predict chemicals as active or inactive.

Results:
The PTML-ANN model displayed sensitivity and specificity higher than 85% in both training
and test sets. The physicochemical and structural interpretation of the molecular descriptors in the model
permitted the direct extraction of fragments suggested to favorably contribute to enhancing the multitarget
inhibitory activity. Based on this information, we assembled ten molecules from several fragments
with positive contributions. Seven of these molecules were predicted as triple target inhibitors while the
remaining three were predicted as dual-target inhibitors. The estimated physicochemical properties of
the designed molecules complied with Lipinski’s rule of five and its variants.

Conclusion:
This work opens new horizons toward the design of multi-target inhibitors for anti- Alzheimer's
therapies.
Computer-Aided Drug Design Applied to Secondary Metabolites as Anticancer Agents
Authors: de Araújo Rodrigo Santos Aquino , da Silva-Junior Edeildo Ferreira , de Aquino Thiago Mendonça , Scotti Marcus Tullius , Ishiki Hamilton M. , Scotti Luciana , Mendonça-Junior Francisco Jaime Bezerra 
Published: June 2020

:
Computer-Aided Drug Design (CADD) techniques have garnered a great deal of attention in
academia and industry because of their great versatility, low costs, possibilities of cost reduction in in
vitro screening and in the development of synthetic steps; these techniques are compared with highthroughput
screening, in particular for candidate drugs. The secondary metabolism of plants and other
organisms provide substantial amounts of new chemical structures, many of which have numerous biological
and pharmacological properties for virtually every existing disease, including cancer. In oncology,
compounds such as vimblastine, vincristine, taxol, podophyllotoxin, captothecin and cytarabine are
examples of how important natural products enhance the cancer-fighting therapeutic arsenal.

:
In this context, this review presents an update of Ligand-Based Drug Design and Structure-Based Drug
Design techniques applied to flavonoids, alkaloids and coumarins in the search of new compounds or
fragments that can be used in oncology.

:
A systematical search using various databases was performed. The search was limited to articles published
in the last 10 years.

:
The great diversity of chemical structures (coumarin, flavonoids and alkaloids) with cancer properties,
associated with infinite synthetic possibilities for obtaining analogous compounds, creates a huge
chemical environment with potential to be explored, and creates a major difficulty, for screening studies
to select compounds with more promising activity for a selected target. CADD techniques appear to be
the least expensive and most efficient alternatives to perform virtual screening studies, aiming to selected
compounds with better activity profiles and better “drugability”.