bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thromboseprophylaxe beim ambulanten Tumorpatienten
Authors: Hart Christina , Heudobler Daniel , Linnemann Birgit 
Published: February 2020

Was ist neu?
Scores zur Stratifizierung des VTE-Risikos bei ambulanten Tumorpatienten Neben dem seit vielen Jahren bekannten Khorana-Score wurde kürzlich der CAT-Score publiziert, mit dem sich das Risiko für eine VTE innerhalb von 6 Monaten nach Einleitung einer Systemtherapie berechnen lässt. Als Berechnungsgrundlage dienen 2 Variablen: Tumorentität sowie Höhe der D-Dimere.
Prophylaxe mit niedermolekularem Heparin Für Tumorpatienten in der ambulanten Versorgung wird eine Thromboseprophylaxe derzeit routinemäßig nicht empfohlen. Eine Stratifizierung des VTE-Risikos vor Einleitung einer Systemtherapie sollte erfolgen. Weitere Risikofaktoren, die in die publizierten Scores nicht eingehen, z. B. VTE in der Anamnese oder Therapie mit antiangiogenen Substanzen, sollten berücksichtigt werden. Eine Prophylaxe mit NMH kann nach individueller Nutzen-Risiko-Abwägung bei Patienten mit erhöhtem VTE-Risiko und vertretbarer Erhöhung des Blutungsrisikos erwogen werden.
Direkte orale Antikoagulanzien zur VTE-Prophylaxe In 2 Studien konnte kürzlich gezeigt werden, dass Rivaroxaban und Apixaban wirksam sind in der Verhinderung einer VTE beim ambulanten Tumorpatienten. Das Risiko für schwere Blutungen war hierbei erhöht. Rivaroxaban und Apixaban sind in dieser Indikation bislang nicht zugelassen.
VTE-Prophylaxe bei Patienten mit multiplem Myelom Eine VTE-Prophylaxe ist bei Patienten mit multiplem Myelom, die unter Therapie mit Thalidomid oder Lenalidomid in Kombination mit hochdosiertem Dexamethason und/oder einem Anthrazyklin stehen, fest etabliert. Je nach zugrunde liegender Risikostratifizierung wird eine Prophylaxe mit Aspirin bei niedrigem Risiko oder NMH bei hohem Risiko empfohlen.
Asymptomatic and Unnoticed Intra-articular Screw Over 18 Years after Fracture of the Posterior Wall of the Acetabulum – a Question of Stability?
Authors: Audretsch Christof K. , Schmidutz Florian , Küper Markus Alexander 
Published: February 2020

AbstractFractures of the posterior wall of the acetabulum occur in a frequency of 25 – 30%. Multifragmentary fractures involving 40 – 50% of the acetabular surface, the quality of reduction as well as involvement of cartilage and acetabular labrum are considered to have an impact on the development of a reduced posterior stability of the hip joint. This results in a shift of the main weight bearing area with development of a posttraumatic osteoarthritis. In the presented case, a 42-year old male patient was operated on 18 years ago due to a posterior acetabular wall fracture. Retrospectively, one of the screws was located partially intraarticular. However, the patient was asymptomatic over the 18-year period. The first consultation was due to unspecific symptoms of osteoarthritis of the right hip joint especially during flexion and external rotation. Due to only mild radiological signs of osteoarthritis, we indicated only the removal of the intraarticular screw. The symptoms
postoperatively switched to a feeling of instability, so a total hip arthroplasty was performed. Since the operation, the patient is asymptomatic regarding the hip joint. The intraarticular screw seemed to stabilize the hip joint. This case demonstrates the importance of a good posterior guidance for the stability of the hip joint on one hand. On the other hand, it demonstrates the minor stress load of the posterior acetabular region, especially after fracture of the posterior wall. Therefore, a good posterior guidance should be one major aim of treatment of posterior acetabular wall fractures.
Effect of Tranexamic Acid on Coagulation and Fibrin Clot Properties in Children Undergoing Craniofacial Surgery
Authors: Fenger-Eriksen Christian , Lindholm Alexander D'Amore , Krogh Lisbeth , Hell Tobias , Berger Martin , Hermann Martin , Fries Dietmar , Juul Niels , Rasmussen Mads , Hvas Anne-Mette 
Published: February 2020

Abstract
Objective Craniosynostosis surgery in small children is very often associated with a high blood loss. Tranexamic acid (TXA) reduces blood loss during this procedure, although the potential underlying coagulopathy in these children is not known in detail. Objective was to determine the nature of any coagulopathy found during and after craniosynostosis surgery and to characterize the effect of TXA on fibrin clot formation, clot strength, and fibrinolysis.
Materials and Methods Thirty children received either TXA (bolus dose of 10 mg/kg followed by 8 hours continuous infusion of 3 mg/kg/h) or placebo. Dynamic whole blood clot formation assessed by thromboelastometry, platelet count, dynamic thrombin generation/thrombin-antithrombin, clot lysis assay, and fibrinogen/factor XIII (FXIII) levels were measured. Additionally, clot structure was investigated by real-time live confocal microscopy and topical data analysis.
Results Increased ability of thrombin generation was observed together with a tendency toward shortened activated partial thromboplastin time and clotting time. Postoperative maximum clot firmness was higher among children receiving TXA. FXIII decreased significantly during surgery in both groups.Resistance toward tissue plasminogen activator-induced fibrinolysis was higher in children that received TXA, as evidenced by topical data analysis and by a significant longer lysis time. Fibrinogen levels were higher in the TXA group at 24 hours.
Conclusion A significant coagulopathy mainly characterized by changes in clot stability and not parameters of thrombin generation was reported. Tranexamic acid improved clot strength and reduced fibrinolysis, thereby avoiding reduction in fibrinogen levels.
Evaluating an Image-Guided Operating Room with Cone Beam CT for Skull Base Surgery
Authors: Muhanna Nidal , Douglas Catriona M. , Daly Michael J. , Chan Harley H.L. , Weersink Robert , Townson Jason , Monteiro Eric , Yu Eugene , Weimer Emilie , Kucharczyk Walter , Jaffray David A. , Irish Jonathan C. , de Almeida John R. 
Published: February 2020

Abstract
Importance Skull base surgery requires precise preoperative assessment and intraoperative management of the patient. Surgical navigation is routinely used for complex skull base cases; however, the image guidance is commonly based on preoperative scans alone.
Objective The primary objective of this study was to assess the image quality of intraoperative cone-beam computed tomography (CBCT) within anatomical landmarks used in sinus and skull base surgery. The secondary objective was to assess the registration error of a surgical navigation system based on intraoperative CBCT.
Design Present study is a retrospective case series of image quality after intraoperative cone beam CT.
Setting The study was conducted at Toronto General Hospital and Princess Margaret Cancer Centre, University Health Network, Toronto.
Participants A total of 46 intraoperative scans (34 patients, 21 skull base, 13 head and neck) were studied.
Main Outcome and Measures Thirty anatomical landmarks (vascular, soft tissue, and bony) within the sinuses and anterior skull base were evaluated for general image quality characteristics: (1) bony detail visualization; (2) soft-tissue visualization; (3) vascular visualization; and (4) freedom from artifacts (e.g., metal). Levels of intravenous (IV) contrast enhancement were quantified in Hounsfield's units (HU). Standard paired-point registration between imaging and tracker coordinates was performed using 6 to 8 skin fiducial markers and the corresponding fiducial registration error (FRE) was measured.
Results Median score for bony detail on CBCT was 5, remaining at 5 after administration of IV contrast. Median soft-tissue score was 2 for both pre- and postcontrast. Median vascular score was 1 precontrast and 3 postcontrast. Median score for artifacts on CBCT were 2 for both pre-and postcontrast, and metal objects were noted to be the most significant source of artifact. Intraoperative CBCT allowed preresection images and immediate postresection images to be available to the skull base surgeon. There was a significant improvement in mean (standard deviation [SD]) CT intensity in the left carotid artery postcontrast 334 HU (67 HU) (p < 10−10). The mean FRE was 1.8 mm (0.45 mm).
Conclusion Intraoperative CBCT in complex skull base procedures provides high-resolution bony detail allowing immediate assessment of complex resections. The use of IV contrast with CBCT improves the visualization of vasculature. Image-guidance based on CBCT yields registration errors consistent with standard techniques.
Screening for the Most Common Mutations of CFTR Gene among Egyptian Children with Difficult-to-Treat Asthma
Authors: Al-Haggar Mohammad , Osman Engy , Eid Abdel-Rahman , Barakat Tarek , El-Morsi Samar 
Published: February 2020

AbstractCystic fibrosis (CF) is panethnic autosomal recessive disease that affects the exocrine glands of pancreas, lungs, and intestine. It is often misdiagnosed in developing countries as difficult-to-treat asthma. We enrolled 150 Egyptian families with one or more probands who were complaining of difficult-to-treat asthma, and 112 cases were studied extensively through history taking including pedigree construction and clinical examination. In addition, spirometry and computed tomography of the chest were done in selected cases. All cases were subjected to quantitative sweat chloride test and molecular screening for the three most common mutations of cystic fibrosis transconductance regulator (CFTR) gene (ΔF508, G542X, W1282X) using amplification refractory mutation system (ARMS) technique. Probands of difficult-to-treat asthma comprised 66 males and 46 females; their age range was 1 to 14 years. Sixty-one probands (54.5%) were carriers of one or more of the studied mutations (36 cases and 25 carriers). Six carriers of single mutations had mild respiratory symptoms and negative sweat test. The most common allele was ΔF508, 60 alleles in 56 individuals (4 were homozygous ΔF508/ΔF508) followed by W1282X in 25 individuals and G542X in 12 individuals. Allele W1282X had an increased risk of recurrent chest infection and bronchiectasis. Moreover, cases with two mutations had more severe symptoms compared with those with a single mutation. CFTR mutations and CF-related syndromes are not rare as thought in Egypt, especially among the high-risk difficult-to-treat asthma. The readily available ARMS technique is recommended for ΔF508 and/or W1282X screening on priority basis among these children.
Online customer behavior: perceptions regarding the types of risks incurred through online purchases
Authors: Marceda Bach Tatiana , da Silva Wesley Vieira , Mendonça Souza Adriano , Kudlawicz-Franco Claudineia , da Veiga Claudimar Pereira 
Published: February 2020

AbastractDeciding to make online purchases can be risky and retailers have an opportunity to influence the consumer’s decision-making process. The aim of this article is to gauge the impact of different types of risks on trust and decision making with regard to online purchases. We conducted a survey with adaptations to three theoretical scales. To analyze the impact of risk on the variables of trust and decision making, a confirmatory factor analysis was performed, and to clarify the relationships between these constructs, a structural equation model was prepared. A qualitative (n = 13) and quantitative study were conducted with primary data (n = 328) collected by means of a structured questionnaire using a sample of a group of consumers who reside in the south of Brazil. The article makes four main contributions to the field: (i) it identifies the influence of three latent constructs that might affect online purchase behavior; (ii) it gauges the risks associated with the latent construct of trust and the adaptation of scales of perceived risk and decision making; (iii) it highlights the need to reassess the strategies adopted by companies that sell online to reduce risks and consequently increase trust in decision making; and (iv) it evaluates the demographic variables that have a significant moderating effect on the relationships of the constructs of trust and decision making during the purchase process.
Real-time particle-by-particle detection of erythrocyte-camouflaged microsensor with extended circulation time in the bloodstream
Authors: Di Wenjun , Tan Xuefei , Calderon Isen Andrew C. , Neal Reilly Ashlyn E. , Niedre Mark , Clark Heather A. 
Published: February 2020

Significance
We developed and validated an approach for long-term in vivo monitoring of sodium levels in the bloodstream using erythrocyte camouflaging of microsensors combined with noninvasive optical readout of the microsensors while in circulation. Sodium imbalance is an important indicator for toxicity during lithium treatment for bipolar disorder. Lithium treatment has a toxic threshold close to its narrow therapeutic window, which drives the need for long-term continuous monitoring to prevent adverse effects. Our study describes an approach to drug monitoring by using biomimicry and optical reader technology, with wide potential impact toward treatment regimens for bipolar disorder and other conditions.
The variation of the subjunctive II in Austria
Authors: Breuer Ludwig Maximilian , Wittibschlager Anja 
Published: February 2020

Abstract
The primary goal of this paper is to investigate areal-horizontal as well as the social-vertical
(morpho-)syntactic variation of subjunctive II in urban and rural areas in Austria. The data come from two different corpora that
consist of spoken data gathered in two different projects on German in Austria, collected using the method of Language Production
Experiments. The high degree of comparability of our data between the two studies highlights the success and reliability of this
elicitation method. Beyond this methodological insight, the study has found a global tendency towards a decline of synthetic
subjunctive II constructions, whereas periphrastic constructions show an increase, both in more dialect and more standard oriented
registers. Our findings further suggest that the city of Vienna exerts a minor influence on neighboring locations regarding the
use of subjunctive II forms. At the same time, our data provide evidence for a more decisive influence of the dialect region.
The rite of reintegrative shaming in Chinese public dispute mediation
Authors: Ran Yongping , Zhao Linsen , Kádár Dániel Z. 
Published: February 2020

Abstract
This paper examines the ways in which mediators deploy the rite of public shaming in the activity type of public
mediation, as a pragmatic device by means of which they exert social control. Our data consists of episodes of public mediation
events in rural China, aired in the Chinese Television. Our analytic framework is anchored to the model of interactional
relational rituals: we interpret shaming as a morally loaded communal interactional practice, which the mediator can deploy due to
their ratified role, but only within frame of the ritual activity type, and with the communal goal of resolving the conflict.
Thus, while ritual forms of shaming may be interactionally intensive – e.g. the person who inflicts shame may inflict shame with
little mitigation to put pressure on the shamed person – strict rights and obligations regulate the behaviour of the mediator who
needs to act as a ‘moral educator’.
What psycholinguistic studies ignore about literary
experience
Authors: Gibbs Raymond W. , Colston Herbert L. 
Published: February 2020

Abstract
Multiple decades of psycholinguistic research exploring people’s
reading of different types of language has delivered much improved understanding
of textual comprehension experience. Psycholinguistic studies have typically
focused on a few cognitive and linguistic processes presumed to be central in
reading comprehension of language, but this emphasis has omitted other processes
and products readers commonly experience in their imaginative, aesthetic
encounters with literature. Our paper describes some of the limitations of
psycholinguistics for explaining people’s literary experiences. Nonetheless, we
argue that recent research on embodied simulation processes may help close the
gap between psycholinguistics, with its emphasis on generic processes of
non-literary language use, and studies associated with the scientific study of
literature with their focus on phenomenological, lived reactions to literary
texts.
Some experimental evidence for sound–emotion
interaction
Authors: Gafni Chen , Tsur Reuven 
Published: February 2020

Abstract
This paper describes a structural account of phonetic symbolism
and submits it to empirical investigation. To enable testing for possible iconic
sound–emotion relations, participants compared pairs of syllables (e.g.,
ma – ba) as well as pairs of emotional
states (e.g., joyful – sad) on various perceptual scales (e.g., softness). In
addition, we replicated the classic ‘bouba/kiki’ experiment to investigate
sound-shape symbolism. In accordance with the theoretical model, the results of
the experimental tasks suggest that participants can detect abstract
similarities between speech sounds and emotions as well as geometrical shapes.
We discuss the theoretical model and the experimental results in relation to
previous empirical findings and conflicting evidence from the study of affective
iconicity in poetry.
Reader expertise and the literary significance of small-scale textual
features in prose fiction
Authors: Parente Fabio , Conklin Kathy , Guy Josephine , Carrol Gareth , Scott Rebekah 
Published: February 2020

Abstract
We use eye tracking to investigate the attention readers pay to
different textual features to determine their significance in the appreciation
of prose fiction. Previous research examined attention allocation to lexical and
punctuation variants, and the impact on reading dynamics for the remainder of
the text, demonstrating that readers notice both kinds of variants but assign
less value to the latter (Carrol, Conklin,
Guy, & Scott, 2016). Here, in two experiments, we examine two
conditions that may affect attention allocation: We investigate the influence of
reader expertise (Experiment 1) and whether performance is influenced by a
task-specific “spot-the-difference” effect (Experiment 2). We found that
expertise plays little role in readers’ greater sensitivity to lexical rather
than punctuation changes, and that the advantage for lexical changes persisted
when the time interval between exposures is increased. These results confirm
earlier findings: that small-scale features may not possess the creative
significance predicated of them by critics and text-editors.
Stochastic cooling simulation of rare isotope beam and its secondary beam
Authors: Hu X J , Wu J X , Zhu G Y , Du Z , Yuan Y J 
Published: February 2020

Abstract
Stochastic cooling is a broadband feedback system, which is very effective for reducing the beam size without beam loss [1]. It has advantage over electron cooling in cooling low intensity beam with large emittance and momentum spread, and is required for precise study of the decay properties of RIB (Radioactive Ion Beam) by use of the SMS (Schottky Mass Spectrometry) method [2]. This paper mainly concerns on cooling of primary beam and its secondary beam, pointing out the range of mass-to-charge spread that could be cooled for secondary particles. Meanwhile, TOF cooling combined with filter cooling was also studied. The simulation results provide theoretical supports for analysing different ions circulating in the ring at the same time in the experiments.
Multipole magnets for the HIAF fragment separator using the Canted-Cosine-Theta (CCT) geometry
Authors: Wu Wei , Liang Yu , Zhou Lun-Cai , Mei En-Ming , Ni Dong-Sheng , Zhen Shi-Jun , Ou Xian-Jin , Yang Wen-Jie 
Published: February 2020

Abstract
The fragment separator of the HIAF (High Intensity Heavy Ion Accelerator Facility) project called HFRS requires quadrupoles with high gradients (11.4 T/m) and large bores (320 mm in diameter). The iron dominated magnets with superconducting coils have been widely used in the similar facilities such as A1900, BigRIPS, Super!FRS and RISP with the advantages of low request for coils installation precision, simple fabrication and low cost, but they have large cold mass and helium containment, which result in long time cooling down and high pressure rise during a quench. In addition, due to iron saturation, it is hard to guarantee on the field quality in the operated field range. A new coil dominated design based on the Canted!Cosine!Theta geometry is presented for HFRS, which is expected to overcome these problems. The design superimposes several layers of oppositely wound helical windings to generate high quality quadrupole. Sextupole, octupole and steering dipole can also be easily integrated to reduce the length of cryostat. This paper reports the detailed design of HFRS multiplets based on the CCT concept and the construction of a subscale prototype.
Design of fast pulse generator for Kicker power supply in HIAF*
Authors: Liu Y , Gao D Q , Zhao J , Gao J , Shang-guan J B 
Published: February 2020

Abstract
Kicker power supply is one of the key components in the injection and extraction system of HIAF (High Intensity Heavy Ion Accelerator Facility, the 12th five-year national big science project). The PFN-Marx generator technology based on solid-state IGBT switch will be applied to HIAF-Kicker power supply. Hundreds of fast pulse signals are required to control these IGBTs. The PFN-Marx generator has many requirements for these control signals, such as adjustable pulse-widths and time-delay. The maximum value of adjustment accuracy of the pulse-widths and delay among multiple control signals need to be 10ns. In this paper, a fast pulse generator circuit based on an emerging ARM-embedded FPGA have been designed for HIAF-Kicker power supply. The test results show that the output performance of the fast pulse generator circuit meets the requirements of the PFN-Marx generator.
Commissioning progress of LEAF at IMP
Authors: Yang Y , Zhai Y H , Jiang P Y , Sun L T , Lu L , Jia H , Dou W P , Fang X , Jing L , Wei Y , Ma W , Sun L P , Lu W , Guo Y H , Liu X J , Zhao H W 
Published: February 2020

Abstract
A Low Energy high-intensity high-charge-state ion Accelerator Facility (LEAF), which mainly consists of a 45 GHz superconducting ECR ion source, LEBT and a 81.25 MHz 4-vane RFQ, was designed to produce and accelerate heavy ions, from helium to uranium with A/Q between 2 and 7, to the energy of 0.5 MeV/u. The typical beam intensity is designed up to 2 emA CW for the uranium beam. The project was launched in 2015 and has been successfully commissioned with He+ (A/Q=4), N2+ (A/Q=7) beam and accelerated the beams in the CW regime to the designed energy of 0.5 MeV/u. Beam commissioning results of He+ beam have been reported previously. This paper presents the details of N2+ commissioning and beam studies.
The digital controller for power supplies in HIAF
Authors: Tan Y L , Gao D Q , Huang Y Z , Cui Y , Zhang H J , Zhang S , Li J Q , Zhu F F 
Published: February 2020

Abstract
High Intensity Heavy Ion Accelerator Facility (HIAF) project has been proposed by Institute of Modern Physics, Chinese Academy of Sciences (IMP) for high power heavy ion researches. Due to the unique requirements of the Booster Ring (Bring) in HIAF, a digital controller is used as the controlling system of power supplies to achieve high performances. This paper explains the hardware and software architecture of the digital controller. It uses Cyclone V SX SoC FPGA which integrates dual-core ARM Cortex-A9 MP Core processor. The controller consists of high precision ADC, DAC, optical fibre modules, DDR3 SDRAM and Gigabit Ethernet modules. The PI regulation and PWM modulation have been realized in FPGA. The data pre-setting, web service, database, power supplies detection and protection management have been established in ARM. Finally, the results of prototype output measurements prove that this design is feasible and qualified.