bluuebunny/crossref_metadata_2025_split huggingface dataset:
Demanda de N, P y K en líneas de maíz de Valles Altos de México
Authors: González-Molina Lucila , Virgen-Vargas Juan , Moreno-Pérez Esaú del Carmen , De Jesús-Prado Tranquilino 
Published: December 2024

La producción comercial de semilla de maíces mejorados presenta diferentes limitaciones; entre éstas, sobresalen, los escasos estudios de nutrición mineral de líneas progenitoras que forman los híbridos comerciales. El objetivo del presente trabajo fue determinar la demanda de N, P y K de líneas de maíz progenitoras de híbridos adaptados a las condiciones de Valles altos de México y estimar su dosis de fertilización con N-P-K. El estudio se llevó a cabo en el Campo Experimental Valle de México del INIFAP. Se usó un diseño experimental en bloques completos al azar en arreglo factorial con dos factores: 1) año de evaluación (2014, 2015 y 2016) y 2) líneas de maíz (M-18 (♂-S2), M-55 (♀-S4), M-45 (♂-S3), M-48 (♂-S3) y CML-456 (♂-S4). En madurez fisiológica, las variables medidas fueron: materia seca, rendimiento de grano, índice de cosecha y la extracción de N, P, y K. La demanda y la dosis de fertilización de N, P (P205) y K (K20) (kg ha-1), en las líneas fueron de: 70 a 115, 0 a 44, 42 a 80; 0, 120 a 249, 0; respectivamente. Las líneas de maíz difirieron en las extracciones y la demanda de N, P y K de acuerdo con el nivel de endogamia, producción de materia seca de planta y rendimiento de grano, y en consecuencia en las dosis de fertilización, aspecto que debe ser considerado en un programa de fertilización para la producción de semilla.
Leveraging Blockchain and AI for Pharma Supply Chain Efficiency
Authors: Venkataraman Mohan 
Published: December 2024

The presentation discusses the potential of blockchain and AI to revolutionize the pharmaceutical supply chain. The author, with a rich history in healthcare technology, highlights the inefficiencies and challenges faced by the industry, particularly in areas like drug discovery, manufacturing, and distribution.

Blockchain technology, with its ability to create immutable records, can enhance transparency, traceability, and security across the supply chain. This can help in tracking the journey of drugs from raw materials to the final product, reducing the risk of counterfeiting and ensuring quality.
AI, on the other hand, can optimize various processes, such as drug discovery, clinical trials, and supply chain logistics. By analyzing vast amounts of data, AI can identify patterns, predict trends, and make informed decisions. This can accelerate drug development, improve manufacturing efficiency, and optimize inventory management.

The integration of blockchain and AI can create a powerful synergy, leading to significant improvements in the pharmaceutical supply chain. This includes enhanced patient safety, reduced costs, and faster time-to-market for new drugs. The presentation provides a concise view of the health care supply chain processes and discusses AI patterns such as RAG, GAM and Fine-Tuning methods such as LoRA and QLoRa that can help in building trust in the supply chain.
Penyesuaian diri pada remaja yang tinggal di ekslokalisasi: Apakah self-esteem berhubungan dengan penyesuaian diri pada remaja yang tinggal di ekslokalisasi?
Authors: Puspita Anggun , Meiyuntariningsih Tatik , Aristawati Akta Ririn 
Published: December 2024

Abstract
This study focuses on assessing the relationship between self-esteem and self-adjustment among adolescents living in ex-localities. The approach applied in this research is a quantitative approach. The research sample consists of adolescents aged 17 to 20 years residing in ex-localities. Data were collected using Likert scales, which included scales for self-esteem and self-adjustment. The method used for data analysis is the Product Moment correlation. The analysis results show a correlation coefficient (r) of 0.728 with a p-value of 0.000, which is less than 0.005. These findings indicate a significant positive relationship between self-esteem and self-adjustment among adolescents in ex-localities. Therefore, the hypothesis identified in this study is accepted.

Abstrak
Penelitian ini berfokus pada penilaian hubungan antara self-esteem dan penyesuaian diri di kalangan remaja yang tinggal di ekslokalisasi. Pendekatan yang diterapkan dalam penelitian ini adalah pendekatan kuantitatif. Sampel penelitian terdiri dari remaja berusia 17 hingga 20 tahun yang berada di ekslokalisasi. Data dikumpulkan menggunakan skala Likert yang mencakup skala harga diri dan penyesuaian diri. Metode yang diterapkan untuk analisis data adalah korelasi Product Moment. Hasil analisis menunjukkan koefisien korelasi (r) sebesar 0,728 dengan nilai p = 0,000 yang kurang dari 0,005. Temuan ini mengindikasikan adanya hubungan positif yang signifikan antara self-esteem dan penyesuaian diri di kalangan remaja ekslokalisasi. Oleh karena itu, hipotesis yang diidentifikasi dalam penelitian ini dapat diterima.
Dukungan sosial teman sebaya dengan tingkat quarter life crisis pada individu dewasa awal
Authors: Hariyanto Dandy Putra , Rina Amherstia Pasca , Sukiatni Dwi Sarwindah 
Published: December 2024

Abstract
This research aims to determine the relationship between peer social support and the level of quarter life crisis in early adult individuals. The subjects of this research were vulnerable individuals aged 19-29 years in the city of Surabaya with a total of 100 respondents. Based on analytical calculations using Spearman Rho, a correlation score of 0.225 was obtained with a significance level of 0.000 (p<0.05), meaning that there was no negative relationship between social support and the quarter life crisis. The result is that the higher the social support an individual has, it has no effect on the level of quarter life crisis experienced by that individual.

Keywords: social support, Quarter life crisis, adult individuals

Abstrak
Penelitian ini bertujuan untuk mengetahui hubungan antara dukungan sosial teman sebaya dengan tingkat quarter life crisis pada individu dewasa awal. Subjek penelitian ini adalah individu di rentan usia 19-29 tahun yang ada di kota Surabaya dengan jumlah responden 100 orang. Berdasarkan perhitungan analisis menggunakan Spearman Rho diperoleh skor korelasi Sebesar 0.225 dengan taraf signifikansi sebesar 0.000 (p<0.05) artinya tidak terdapat hubungan negatif antara dukungan sosial dengan quarter life crisis. Hasilnya semakin tinggi dukungan sosial yang dimiliki individu tidak berpengaruh terhadap tingkat quarter life crisis yang dialami oleh individu tersebut.

Kata Kunci: Dukungan Sosial, Quarter life crisis, Remaja Awal
Oxidative stress and metabolic syndrome in Alzheimer’s disease: the search for a relationship
Authors: Zalutskaya N. M. , Dubinina E. E. , Gomzyakova N. A. , Yushchin K. V. , Neznanov N. G. 
Published: December 2024

The article addresses the problem of Alzheimer’s disease (AD) from the perspective of the interaction between two important pathological processes: oxidative stress and metabolic disorders. Although histopathological changes in early and senile dementia are similar, and both variants are attributed to AD, individuals with early-onset AD (EOAD) demonstrate a more aggressive course of the disease with rapid cognitive decline and fewer concomitant morphological changes. The development of late-onset AD (LOAD) depends on multiple environmental factors, lifestyle, and, among other things, the functioning of general adaptation mechanisms, including redox, immunological, and hormonal systems.The article pays special attention to the role of metabolic syndrome (MS) as an important risk factor not only for cardiovascular and cerebrovascular diseases but also for AD. The presence of MS in individuals over 60 years of age increases the risk of developing dementia by 13% under the age of 60 and by 8% between the ages of 60 and 70. The article emphasizes the importance of oxidative stress (OS), which causes oxidation of biomolecules and tissue damage, in the pathogenesis of metabolic disorders and the development of MS. Possible mechanisms of the relationship between oxidative stress processes and metabolic disorders are described. Understanding the mechanisms of AD and MS development, as well as their interrelation, is key to developing effective methods for preventing and treating these diseases.
PENGEMBANGAN POWERPOINT PRESENTATION BERBASIS MULTIPEL REPRESENTASI KIMIA TERINTEGRASI AYAT AL-QURAN PADA MATERI BENTUK MOLEKUL DI KELAS XI SMAN 2 BATUSANGKAR
Authors: Rezki Rezki , Herman Mimi , Rahmi Elvy , Hidayat Herman 
Published: December 2024

Integrasi nilai-nilai spiritual ke dalam pembelajaran kimia merupakan upaya strategis untuk meningkatkan pemahaman konsep sekaligus membangun karakter peserta didik. Salah satu pendekatan yang dapat dilakukan adalah pengembangan media pembelajaran berbasis multipel representasi kimia dengan memadukan ayat-ayat al-Qur'an. Penelitian ini bertujuan mengembangkan media PowerPoint Presentation berbasis multipel representasi kimia yang terintegrasi ayat al-Qur'an pada materi bentuk molekul yang valid dan praktis. Uji Validitas meliputi tiga aspek: validitas materi (kimia dan integrasi ayat al-Qur'an), bahasa, serta media. Metode penelitian menggunakan model pengembangan R&D dengan tahapan 4D hingga tahap development. Hasil validasi menunjukkan media sangat valid dengan skor kelayakan materi 91,67% (kimia) dan 100% (ayat al-Qur'an), bahasa 90,9%, serta media 94,31%. Praktikalitas peserta didik menunjukkan skor 84,98% (sangat praktis), sementara wawancara dengan pendidik menyatakan media ini sangat praktis. Berdasarkan hal tersebut, dapat disimpulkan media PowerPoint yang dikembangkan sangat prakis dan sangat valid serta dapat membantu memahami konsep kimia dan membangun karakter peserta didik.
Discretionary Care
Authors: Khan Sanaullah 
Published: December 2024

Abstract
Following changes in law and court practices in Pakistan, individuals who have been incarcerated and have mental illnesses in Pakistan experience changing forms of bureaucratic violence as they undergo psychiatric screening. This happens in the context of a move by the Supreme Court of Pakistan to treat mental illness as a mitigating factor in crimes such as blasphemy or murder. The article explores the ways in which ‘patient-prisoners’ are over and under-psychiatrized given the discretionary ways in which psychiatric evidence is used to judge criminality. In some cases, prisoners wait to be labelled ‘mentally sound’ to stand trial and to defend themselves, experiencing pressure to obey discipline in prison despite their severe mental illnesses, representing a modality of under-psychiatrization. In other cases, bureaucratic violence inflicted on patient-prisoners includes over-psychiatrization when state officials seek psychiatric causes for crimes even when they are absent, resulting in delays in court proceedings.
VALIDATION OF CORROSION STATUS OF SOME ROOFING SHEETS UTILIZED IN GOMBE METROPOLIS
Authors: Usman Y. M. , Mohammed A. B. , Muzakir M. M. , Madaki L. A. , Modibbo U. U. 
Published: December 2024

The study was aim at investigation the level of corrosion on roofing sheets utilized in Gombe where acid and alkaline medium immersion test of 25 days showed that light zinc (0.15 mm) sample decreased in weight from 0.03g to 0.04 g while the 2.0mm zinc decreased in weight range of 0.01g to 0.04 g in the alkaline solution. Samples of thick aluminum (5.5 mm) and light aluminium(4.5mm) showed insignificant weight range 0.0g to 0.03 g after immersion in alkaline. In acidic medium both light and thick zinc showed greater weight lost 0.05g to 0.08g. However both the thick and light aluminium showed loss of their shiny appearance only with no renowned significant corrosion throughout the twenty-five days of immersion. XRF analysis of the oxides on the corrosion samples of 0.15mm zinc showed decreasing pattern of: Fe2O3 > SiO2.> Na2O >Al2O3 > MnO > CaO respectively. The decreasing order of the percentage of oxides on 2.0mm zinc: Fe2O3 > SiO2 .>Al2O3 > CaO > MnO oxides on 4. 5mm. Aluminium is in decreasing order of; Al2O3 > SiO2.> Fe2O3 > CaO > K2O . On the other side percentage of the oxides of 5.0mm Aluminium is Al2O3 > SiO2 > MnO respectively. Aluminium samples are more durable and resistant which indicates suitability for roofing than zinc sheets.
PENGEMBANGAN KOMPONEN INSTRUMEN TERPADU (KIT) PRAKTIKUM KIMIA
Authors: Tiara Juliani  , Elvinawati  , Febrian Solikhin  
Published: December 2024

Penelitian ini bertujuan untuk mengetahui kelayakan dari KIT praktikum, respon dan kemampuan psikomotorik peserta didik setelah menggunakan media alternatif KIT yang dikembangkan. Pengembangan KIT praktikum kimia ini menggunakan pengembangan ADDIE. Penelitian ini dilakukan di SMA Negeri 9 Kota Bengkulu dengan subjek penelitian yaitu 12 orang peserta didik kelas XI MIPA 2 untuk uji coba kelompok kecil dan seluruh peserta didik kelas XI MIPA 3 SMA Negeri 8 Kota Bengkulu dan SMA Negeri 9 Kota Bengkulu untuk uji coba kelompok besar. Instrumen pada penelitian ini yaitu lembar wawancara, angket kebutuhan peserta didik, lembar validasi, angket respon peserta didik, dan lembar penilaian psikomotorik. Hasil penelitian ini diperoleh (1) Tingkat kelayakan KIT praktikum kimia yaitu 94,05% dengan kategori sangat valid, (2) Hasil respon peserta didik terhadap KIT praktikum pada materi kalorimeter memperoleh persentase 89,06% dengan kategori sangat baik, (3) Kemampuan psikomotorik peserta didik memperoleh rata-rata persentase pada SMA Negeri 8 Kota Bengkulu sebesar 92,17% dan SMA Negeri 9 Kota Bengkulu sebesar 96,95% dengan kategori sangat baik. Hasil penelitian ini menunjukkan KIT praktikum kimia pada materi kalorimeter telah dikembangkan sangat layak untuk digunakan dan diterapkan pada proses pembelajaran.
Molecular aspects of predicting recurrence of retroperitoneal extraorgan liposarcomas
Authors: Kolesnikov E. N. , Maksimov R. A. , Demidov S. I. , Timoshkina N. N. , Vlasov S. N. 
Published: December 2024

Purpose of the study. The aim of the work was to optimize the prognosis of recurrences of retroperitoneal extraorgan liposarcomas of various degrees of differentiation by detecting microRNAs (miRNAs) of tumor cells with differential expression depending on the course of the malignant disease.Materials and methods. The study was conducted on 96 patients: 19 patients with lipomas and 77 patients with retroperitoneal extraorgan liposarcomas. Tissue samples were obtained during the operation. Among patients with malignant diseases, highly differentiated liposarcoma (VDLS) was detected in 51 patients, and dedifferentiated (DDLS) in 26 patients. miRNA expression levels in tumor cells were determined using real-time PCR.Results. During the follow-up period, relapses of malignant disease were detected in 25 (32,5%) people: 13 (25,5%) among patients with VDLS and 12 (46,2%) among patients with DDLS. In DDLS, characterized by a more aggressive course, there was an increased level of expression of miRNA155, -21, -26a2 and a decrease in expression of miRNA15a and -34 compared with patients with VDLS. In patients with recurrent retroperitoneal liposarcomas, the expression of miRNA15a was initially 83% lower in tumor cells of surgical samples (p<0,001), iRNA34 by 79% (p< 0,001), and the expression activity of miRNA155 was 7,54 times higher (p<0,001) and miRNA26a2 by 6,93 times (p<0,001).Conclusion. The determination of the expression of miRNA155, -26a2, -34, -15a in tumor cells during surgical treatment of patients with retroperitoneal liposarcomas is an effective way to assess the risk of recurrence and is relevant for determining the tactics of further treatment of patients.
Assessment of the quality of life of oncological patients with skin toxicity depending on telemedicine technologies
Authors: Kutina A. Yu. , Orlova E. V. , Sekacheva M. I. , Briko N. I. , Torchinskiy N. V. 
Published: December 2024

Relevance. Approximately 90–100% of patients have skin toxicity, which manifests itself in the form of acne-like rashes (papulo-pustular rash), paronychia, hair changes, xerosis, itching. Skin manifestations cause psychological, emotional and physical discomfort, which may be the reason for dose reduction or discontinuation of treatment, and may reduce the effectiveness of antitumor therapy. The use of modern telemedicine systems, such as online consultations and remote monitoring, are designed to make life easier for patients and are now increasingly available and in demand among the general population. The aim of the study. Assessment of the quality of life in cancer patients receiving EGFR inhibitors, depending on the use of remote consultations and remote monitoring.Materials and methods. 140 cancer patients were included in the study. All patients were divided into two groups: in group 1 (study group) n=70, the mobile application «My Health» was used for online-consultation with a dermatologist, in group 2 (comparison group) n=70, offline consultations were used. During the consultations, skin toxicity was assessed using CTCAE scales version 5.0. To analyze the level of quality of life, a questionnaire of the dermatological quality of life index (DLQI) was used, which patients of each group filled out on the day of the start of the study, then after 4 weeks.Results. In patients of the first group, there was a positive dynamic in the state of the skin process compared with the initial indicators. There was a statistically significant improvement in the quality of life, a decrease in the average score for all indicators. In patients of the second group, the positive dynamics of the skin process was not so obvious, as evidenced by the results of the questionnaire. There was a statistically significant strong direct correlation between the value of the results of DLQI and the severity of the disease (rs=0.721 p <0.001).Conclusion. Skin toxicity is a complex interdisciplinary problem that requires an integrated approach between oncologists and dermatologists. Remote monitoring is an accessible form of communication between a doctor and a patient, which contributes to the timely control of skin toxicity in cancer patients receiving EGFR inhibitors.
Possibilities of whole body MRI in assessing the prevalence of malignant tumor process
Authors: Prokhorov S. N. , Kochergina N. V. , Ryzhkov A. D. , Krylov A. S. , Bludov A. B. , Nikolaeva E. A. 
Published: December 2024

Purpose. To evaluate the capabilities of whole-body MRI based on accelerated acquisition sequences in assessing the extent of malignancy.Material and methods. The study included 30 patients with malignant, solid tumors of various origins and metastatic lesions of various anatomical structures. All patients underwent WB-MRI, based on accelerated data collection sequences, with subsequent clarifying studies, such as CT, PET/ CT, ultrasound to confirm or refute the malignancy of the detected changes.Results. In 14 out of 30 cases, it was possible to identify additional localizations of metastatic lesions, excluding skeletal bones.Conclusion. In modern conditions, WB-MRI makes it possible to collect comprehensive information for staging a tumor disease in a relatively short period of time.
Polymorphonuclear myeloid-derived suppressor cells regulates immune recovery during HIV infection through PD-L1 and TGF-β pathways
Authors: Wang Zihua , Hu Yue , Song Jing , Ma Ping , Xia Huan 
Published: December 2024

BackgroundAlthough MDSCs are widely recognized for their immunoinhibitory effects in pathological conditions, their function during HIV infection particularly within the mechanisms underlying incomplete immune recovery remains elusive.MethodsWe conducted a cross-sectional study in which 30 healthy controls and 62 HIV-1-infected subjects [31 immunological non-responders (INRs) and 31 immunological responders (IRs)] were selected. The proportion of MDSCs was determined in each category of participants. Using flow cytometry and real-time PCR, immune regulatory molecules (including PD-L1, ARG1, iNOS, IL-10, TGF-β, and IDO) that are relevant for MDSCs activity were quantified. Furthermore, we investigated the impact of the blockade of PD-L1 and TGF-β pathways on MDSCs and their effects on CD4+ T-cells using in vitro functional experiments.ResultsPMN-MDSCs are more abundant and are negatively correlated to CD4 counts in HIV-infected individuals. In addition, PMN-MDSCs suppress CD4+ T-cell proliferation and IFN-γ production in INRs. Furthermore, correlations were found between PD-L1 expression on PMN-MDSCs and PD-1+ CD4+ T-cells. TGF-β expression on PMN-MDSCs was likewise enhanced in INRs. Importantly, inhibiting both PD-L1 and TGF-β pathways had a synergistic impact on restoring CD4+ T-cell activity in vitro.ConclusionsPMN-MDSCs expansion inhibits CD4+ T-cell responses. We suggest that targeting PD-L1 and TGF-β pathways together may significantly improve immune recovery in INRs.
A content analysis of government-issued social media posts during multi-jurisdictional enteric illness outbreaks in Canada
Authors: Patel Vayshali , Grant Lauren E. , Shereefdeen Hisba , MacKay Melissa , Cheng Leslie , Phypers Melissa , Papadopoulos Andrew , McWhirter Jennifer E. 
Published: December 2024

IntroductionMost Canadians use at least one social media platform regularly, making social media a potentially effective tool for reaching broad audiences. The Public Health Agency of Canada (PHAC) uses social media as one tool for rapidly communicating with the public during multi-jurisdictional enteric illness outbreaks. However, the effectiveness of social media in enhancing public risk communication during these outbreaks remains unexplored. Addressing this gap may help optimise social media use for risk communication to inform the public and prevent additional illness. This study aims to analyse the engagement with and quality of PHAC’s social media content regarding multi-jurisdictional enteric illness outbreaks.MethodsUsing a search of PHAC’s social media platforms, 482 posts during enteric illness outbreaks (2014–2022) were identified, including 198 posts from Facebook and 284 posts from X (formerly Twitter) in English and French. A codebook was developed using engagement metrics for gauging public interest, the Centers for Disease Control and Prevention’s (CDC) Modified Clear Communication Index (CCI) to assess clarity as a proxy for comprehension, the Health Belief Model (HBM) to evaluate the potential to motivate behaviour change, and measures of consistency. Descriptive statistics were used to analyse post content.ResultsThe average engagement rates for PHAC social media accounts were &lt; 1%, below standard average engagement rates (1–5%). While posts generally adhered to the CDC’s CCI criteria, clear language (45.7% on Facebook, 26.5% on X) and clear communication of risk (7.6% on Facebook, 0.0% on X) were scarce. HBM constructs were present in all posts, but certain constructs, such as barriers were used sparingly (1% on Facebook, 0% on X). Despite this, posts consistently communicated outbreak investigation details and prevention information.DiscussionThe low average engagement rates suggest a lack of public awareness or interest in the posts. The partial adherence to the CCI indicates room for improvement in clarity, a key component for supporting public understanding. Although some HBM constructs were utilised, no posts incorporated all HBM constructs, which may hinder efforts to promote behaviour change. To enhance effective risk communication using social media during multi-jurisdictional enteric illness outbreaks in Canada, tools like the CDC’s CCI should be used to improve message clarity, use of all HBM constructs as applicable, and message consistency across products and channels are recommended to improve overall message quality and content.