bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isolation and Determination of the Major Principle or Causative Agent behind the 2016 Published Break through Discovery of Dr. M.S. Reddy’s “Multiple Mixed Strain Probiotic Therapy”, in Successfully Treating the Lethal Hospital Acquired Infections Due to
Authors: Reddy Malireddy S , Reddy D.R.K 
Published: August 2020

A multiple mixed strain Probiotic culture was compounded using several naturally antibiotic resistant beneficial microorganisms belonging to different genera and species, along with their bacteriocins and growth end products or metabolites. Prior to mixing several individually grown single strains of Probiotics, compatibility studies were conducted to eliminate the strain dominance in the mixed cultures using direct differential plating techniques and strain specific bacteriophages,using the procedures outlined in our earlier publication. The multiple mixed stain Probiotics thus prepared were studied to see weather Probiotic bacteria by themselves or their bacteriocins and other end products of growth (without the live Probiotics) or the combination of live Probiotics and their bacteriocins and other growth end products, were responsible to inhibit the growth and proliferation of the lethal hospital acquired infections i.e., Clostridium difficile (C. diff) and Methicillin Resistant Staphylococcus aureus (MRSA). In addition, several procedures of preparing the functional mixed strain Probiotics, using liquid nitrogen freezing and freeze drying (lyophilization)were evaluated,tocomeupwiththebest
procedure suitable to maximize their subsequent inhibitory effect on C. diff and MRSA, both under the laboratory conditions and in the practical clinical hospital conditions. Community based clinical trials were conducted to check the effect of multiple mixed strain Probiotics with and without their bacteriocins and their other growth end products, to cure the lethalC. diff infection under practical hospital conditions. The results revealed and confirmed that our 2016 novel discovery is still the best way to prepare and administer the multiple mixed strain Probiotics to treat the lethal hospital acquired infections. Also this study reconfirmed that the liquid nitrogen freezing is far superior to freeze drying or lyophilization to preserve the maximum efficiency of multiple mixed strain Probiotics. In conclusion, it proved that even the concentrated high bacterial cell number multiple mixed strain Probiotics (without their bacteriocins and other growth metabolites) are not as effective compared to the multiple mixed strain Probiotics frozen using liquid nitrogen, along with their bacteriocins and growth metabolites, to cure the lethal C. diff infection under practical clinical hospital conditions.
Error Analysis: A Methodological Exploration and Application
Authors: McDowell Leigh 
Published: August 2020

Error Analysis (EA) was initially conceived in early Second Language Acquisition research in the 1960s to investigate the systems underlying learner language and has since gained wider application in English Language Teaching research. However, for many language teachers, the practical and technological barriers to employing EA in their professional practices remain restrictively high. This paper demonstrates a simple yet robust procedure for EA that can be applied by anyone with access to the commonly available tools of Microsoft Word and Excel. Additionally, by drawing on data from an EA of 18 texts written by Japanese materials scientists, the paper illustrates how this procedure can inform language teaching practices by identifying the most pressing grammatical needs within a population of L2 English users.
本来、誤答分析（Error Analysis）は、語学学習者の言語の根本にあるシステムを調査する為に1960年代の初期第二言語習得（SLA）研究中に提案されていて、その後英語教授法（ELT）研究に広く使われるようになった。しかし、多くの語学教師等にとっては、仕事に誤答分析を用いるには技術的な壁が未だに高い。本論文では、一般的に使われているワードやエクセル等によって簡単で確実に誤答分析が出来る方法を紹介する。また、18名の日本人の材料科学研究者の文章の誤答分析のデータを用いて、どのようにしてこの方法を使って言語教育法を明確に出来るかを、第二言語として英語を話すグループの課題となる文法の必要性を示しながら、を説明する。
Learner Use of Photo-Editing Software in Classes
Authors: Grandon Marcus 
Published: August 2020

In this classroom research project, 27 learners in three courses at one university use professional-level, photo-editing software to create and remix images in language lessons. The overarching purpose of this study is to deepen understanding of what actually occurs in lessons through the use of materials. I delivered these lessons with a Content and Language Integrated Learning approach in which English was used for both the teaching and learning of not only lesson content but also language (Coyle, Hood, & Marsh, 2010). Data include emails written by the learners to describe and evaluate their experiences with the software, digital artifacts created during the courses, and my research journal. Qualitative analysis is conducted in a grounded fashion using iterative coding (Saldaña, 2013) to identify emergent themes from a research perspective of materials use. Learners appear to demonstrate self-direction and creativity in highly personal ways throughout the lessons.
本授業調査研究では、ある大学における３つのコースにおいて、27人の学習者が専門家レベルの写真編集ソフトウェアを使用し、語学の授業内で画像の作成およびリミックスを行った。この研究の包括的な目的は、学習者にこれら諸教材を用いることにより授業中に起こることを深く理解させることである。本研究指導者は、授業内容だけでなく言語教育と学習の両方に英語を使用するContent and Language Integrated Learning（内容言語統合型学習）によるアプローチを用いた (Coyle, Hood, & Marsh, 2010)。データには、ソフトウェアを用いた経験を説明および評価するために学習者が書いた電子メール、コース中に作成したデジタルアーティファクト、および指導者が所持する研究ジャーナルを含む。質的分析には、教材使用の研究展望から生まれてくるテーマを特定するために反復コーディング (Saldaña, 2013)を用いた。学生はレッスンを通じ、自分なりのやり方で自己主導性と創造性を示した。
The Most Effective Drugs For Pecilomycose
Authors: Mamatkulovna Vahidova Adolat , Nurmamatovna Hudoyarova Gavxar 
Published: August 2020

Echinococcosis remains a problematic issue in Uzbekistan as well. Many Uzbek and Russian scientists have been studying the spread of echinococcosis among the population and farm animals of Uzbekistan. In this article, we discuss of echinococcosis as the main issue in our country.
Evolution of an Asteroid Family under YORP, Yarkovsky, and Collisions
Authors: Marzari Francesco , Rossi Alessandro , Golubov Oleksiy , Scheeres Daniel J. 
Published: August 2020

Abstract
Any population of asteroids, like asteroid families, will disperse in semimajor axis due to the Yarkovsky effect. The amount of drift is modulated by the asteroid spin state evolution, which determines the balance between the diurnal and seasonal Yarkovsky forces. The asteroid’s spin state is, in turn, controlled in part by the Yarkovsky–O’Keefe–Radzievskii–Paddack (YORP) effect. The otherwise smooth evolution of an asteroid can be abruptly altered by collisions, which can cause impulsive changes in the spin state and can move the asteroid onto a different YORP track. In addition, collisions may also alter the YORP parameters by changing the superficial features and overall shape of the asteroid. Thus, the coupling between YORP and Yarkovsky is also strongly affected by the impact history of each body. To investigate this coupling, we developed a statistical code modeling the time evolution of semimajor axis under YORP–Yarkovsky coupling. It includes the contributions of NYORP (normal YORP), TYORP (tangential YORP), and collisions whose effects are deterministically calculated and not added in a statistical way. We find that both collisions and TYORP increase the dispersion of a family in semimajor axis by making the spin axis evolution less smooth and regular. We show that the evolution of a family’s structure with time is complex and collisions randomize the YORP evolution. In our test families, we do not observe the formation of a “YORP-eye” in the semimajor axis versus diameter distribution, even after a long period of time. If present, the “YORP-eye” might be a relic of an initial ejection velocity pattern of the collisional fragments.
Processus groupaux avec des enfants présentant des troubles autistiques : intersubjectivité primaire, rythmicité, rivalité
Authors: Vogt Justine 
Published: August 2020

Le dispositif groupal est régulièrement proposé comme prise en charge pour des enfants présentant une symptomatologie autistique. Ce travail thérapeutique en groupe a pour but de favoriser les mises en relation et les interactions. Dans le cas des troubles autistiques, ce type de prise en charge soulève pourtant un paradoxe. L’isolement et les symptômes rencontrés dans cette pathologie interrogent sur la manière dont se constituent ces groupes. De quels types de groupe s’agit-il et quelle mobilisation psychique groupale s’opère-t-elle ? À partir d’une même séance de groupe, je propose d’étudier les processus groupaux saillants autour des formes d’intersubjectivité primaire, de la rythmicité et de la rivalité.
Résonances intergroupes et surdités groupales. L’écoute des groupes, son analyse, en musicothérapie analytique de groupe
Authors: Lecourt Édith , Julian Isabelle 
Published: August 2020

Après une présentation du dispositif de musicothérapie analytique de groupe, les auteures développent un exemple clinique d’observation par l’écoute du groupe, et l’écoute de ce groupe par trois autres groupes (dans des situations d’examen) à des fins de comparaison des observations faites. Il en ressort un rapport de la qualité de ces observations au vécu, par le groupe observateur, de sa propre analyse sonore. Dans le cas présenté, l’observation la plus éloignée du vécu du groupe observé a consisté à projeter sur ce dernier une expérience d’illusion groupale, idéal auquel ce groupe d’observateurs n’avait pas pu, lui-même, avoir accès. Cette projection le rendit sourd aux difficultés et angoisses du groupe observé. Cet article se termine par une réflexion sur les rapports d’ambiguïté et d’ambivalence dans cette situation en relation avec les travaux de S. Amati-Sas et J. Bleger.
Groupe à médiation théâtre d’ombres avec des sujets déments : de l’ombre du moi à la lumière de soi
Authors: Souihi Linda , Talpin Jean-Marc 
Published: August 2020

La maladie démentielle pousse le sujet à réactualiser ses expériences passées afin de combler les trous de pensée incombant aux processus de déliaison. Le démantèlement de la pensée réflexive amène la psyché à prendre appui sur une pensée archaïque ou animiste qui s’étaye sur le processus hallucinatoire utilisé comme moyen de symbolisation. L’hallucinatoire dont il est question dans cet article se réfère essentiellement à la « dynamique transformationnelle » de ce processus : sa mise en œuvre s’appuie sur une composante animiste de la pensée étayée sur la matérialisation de l’objet de médiation. La part vivante du moi peut se refléter à travers un mécanisme de personnification (propre à l’animisme) transféré sur l’objet, ici l’ombre, signe d’une re-création psychique et marque d’une subjectivité à retrouver. Le travail groupal, par les processus de déliaison/reliaison, permet au sujet dément d’avoir accès à une « réanimation psychique », à une remise en contact avec son monde interne, avec le monde externe et les autres. Nous proposons de rendre compte de certains de ces princeps à partir de l’exemple clinique d’un groupe à médiation théâtre d’ombres.
The Structural Basis of IRF-3 Activation upon Phosphorylation
Authors: Jing Tao , Zhao Baoyu , Xu Pengbiao , Gao Xinsheng , Chi Lei , Han Huajun , Sankaran Banumathi , Li Pingwei 
Published: August 2020

Abstract
The innate immune system is the first line of defense against bacterial and viral infections. The recognition of pathogen-associated molecular patterns by the RIG-I–like receptors, TLRs, and cGAS leads to the induction of IFN-I by activating the transcription factor IRF-3. Although the mechanism of IRF-3 activation has been extensively studied, the structural basis of IRF-3 activation upon phosphorylation is not fully understood. In this study, we determined the crystal structures of phosphorylated human and mouse IRF-3 bound to CREB-binding protein (CBP), which reveal that phosphorylated IRF-3 forms a dimer via pSer386 (pSer379 in mouse IRF-3) and a downstream pLxIS motif. Size-exclusion chromatography and cell-based studies show that mutations of key residues interacting with pSer386 severely impair IRF-3 activation and IFN-β induction. By contrast, phosphorylation of Ser396 within the pLxIS motif of human IRF-3 only plays a moderate role in IRF-3 activation. The mouse IRF-3/CBP complex structure reveals that the mechanism of mouse IRF-3 activation is similar but distinct from human IRF-3. These structural and functional studies reveal the detailed mechanism of IRF-3 activation upon phosphorylation.
Arnold Chiari Malformation Type-2, fetal magnetic resonance imaging findings in a case
Authors: ATES Fatih , Sara Halil İbrahim , DURMAZ Mehmet Sedat 
Published: August 2020

Abstract
Arnold-Chiari malformation (ACM) is one of the factors that cause death in newborns and infants. Ultrasound (US) is the preferred imaging method for pregnant patients. For the diagnosis of ACM II in the developing fetus, direct and indirect sonographic findings must be fully known. However, Magnetic Resonance Imaging (MRI) is increasingly used in patients whose sonographic diagnosis is uncertain. Fetal MRI is performed for patients such as central nervous system (CNS) abnormalities, neural tube defects, congenital diaphragmatic hernia and masses obstructing the airway that are considered fetal surgery. In this case report, ACM-II detected at 23 weeks 4 days of gestation was presented. The role of prenatal MRI in the recognition of these features, malformation and prognostic value was discussed.
El Docente de Maestría en Docencia Universitaria: modelo de identificación
Authors: García Lemus Alba Indira 
Published: August 2020

En el presente artículo se expone los principales resultados de la tesis “Perfil Integral del Docente de Maestría en Docencia Universitaria y su importancia en la formación del estudiante”, el objetivo del estudio es identificar el perfil del Docente del Postgrado de la Maestría en Docencia Universitaria (en adelante identificada con las siglas, MDU) y analizar la importancia de este perfil en la formación del estudiante. La muestra para el estudio se constituyó en 38 estudiantes y 7 docentes, se utilizaron encuestas y entrevistas semiestructurada. El enfoque de investigación utilizado fue mixto. El diseño fue explicativo secuencial. El componente cuantitativo estuvo enmarcado dentro de un diseño no experimental y transeccional. Para el componente cualitativo se trabajó en la línea de teoría fundamentada. Entre los hallazgos más relevantes encontrados, según lo expuesto en las respuestas a las encuestas; los docentes impactan positivamente con su ejemplo y ética, demuestran dominio disciplinar, usan técnicas y herramientas de evaluación diagnostica, formativa y sumativa, trabajan en base a competencias, utilizan el enfoque sociocritico formativo para desarrollar el pensamiento crítico natural, estimulan la investigación para nutrir el conocimiento, apoyan la participación ciudadana del estudiantado con fines de desarrollo, motivan el desarrollo profesional y el compromiso social del estudiante. Su perfil es integral y juega un papel muy importante en la formación del estudiante, debido a que son ejemplo multiplicador y modelos de identificación.
Prevalence and Predictors of Harmful Alcohol use in a Sub-urban Community in North-Central Nigeria
Authors: Akosu TJ , Afolaranmi TO , Lar L , Chirdan O 
Published: August 2020

Alcohol is a commonly used beverage with adverse health and socio-economic consequences when consumed in excessive amounts. This study determined the prevalence and predictors of hazardous alcohol use in a sub-urban community in Plateau state, Nigeria. Consenting adults aged 18 years and above were selected using multi stage sampling technique. They completed a semi–structured interviewer administered questionnaire adapted from Short Michigan Alcoholism Screening Test–Geriatric Version (SMAST-G) and the World Health Organization's Alcohol Use Disorders Identification Test (AUDIT) tools. Majority 154 (55) of the 280 respondents were males and about half were farmers. About 150 (53.6) of respondents had ever consumed alcohol as at the time of data collection and112 (77.4) of them were currently using alcohol. Harmful use was prevalent in 93 (83) of current users. Being male, belonging to age group 38-45years, and being a civil servant or a business person positively predicted harmful use of alcohol while consuming burukutu, was a negative predictor of harmful use. Control efforts need to target these groups to reduce the negative health and socio-economic consequences of alcohol use in the community.
A juxtaposition of safety outcomes between various doses of sodium-glucose co-transporter inhibitors, in insulin-treated type-1 diabetes mellitus patients: a protocol for systematic review and meta-analysis of randomized controlled trials
Authors: Saha Sumanta 
Published: August 2020

Background: Several clinical trials have tested the safety profile of sodium-glucose co-transport inhibitors’ (SGLTis) in adult type 1 diabetes mellitus (T1DM) patients. However, no systematic review has yet compared its variation between large and low dose SGLTis. Henceforth, a review protocol is proposed here to review it.
Methods: Different electronic databases will be searched for randomized-controlled trials (published in the English language) studying the above objective, irrespective of their publication date. After selecting the eligible trials, their data on the study design, population characteristics, compared interventions, and outcomes of interest will be extracted. Then, utilizing the Cochrane tool, each trial's risk of selection bias, detection bias, performance bias, attrition bias, reporting bias, and other bias will be judged. Next, depending on clinical heterogeneity among the trials, a random-effect or fixed-effect model meta-analysis will be used to compare the respective outcomes. Via the Chi2 and I2 statistics, the statistical inconsistency among the trials will be estimated. When this is substantial, subgroup analysis will follow. Publication bias will be evaluated by funnel plots and Egger’s test. A sensitivity analysis will be done to check different assumptions. If a quantitative juxtaposition is not possible, a narrative reporting will ensue.
Conclusion: The proposed study will perform a dose-wise juxtaposition of the safety profile of SGLTis in insulin-treated T1DM patients.
Registration: Prospective Register of Systematic Reviews (PROSPERO) (Registration no. CRD42019146578)
Elementos da Prática da Terapia Ocupacional na Síndrome do Túnel do Carpo: Um Estudo Bibliográfico
Authors: Sousa Laryssa Bryd Gomes de , Altafim Leticia Zanetti Marchi , Barreto Renata Gomes , Sousa Wendy Chrystyan Medeiros de 
Published: August 2020

A mão é responsável por grande parte da realização das atividades diárias e com isso tende a ter um maior risco de lesão. Dentre as várias doenças que acometem este segmento do corpo, a síndrome do túnel do carpo (STC) é uma doença que tem incidência elevada. A Terapia Ocupacional é uma profissão que trabalha com desempenho funcional, e a STC é uma neuropatia que causa prejuízo no desempenho ocupacional, assim se faz necessário o uso de alguns elementos em sua prática, como forma de avaliar, prevenir e/ou reabilitar. Portanto este artigo teve por objetivo buscar na literatura estudos sobre elementos da prática da Terapia Ocupacional, utilizados na Síndrome do Túnel do Carpo. Os resultados foram estruturados em uma tabela para melhor organização e divididos em três categorias: Estudos com foco nos instrumentos de avaliação, estudos com foco na prevenção e estudos com foco na intervenção/reabilitação. Observou-se que apesar dos artigos terem elementos da Terapia Ocupacional, poucos deles se referiam à prática da profissão, apesar da doença causar danos tanto no desempenho funcional como no contexto social do indivíduo. AbstractThe hand is responsible for performing a large part of daily activities and, as a result, tends to have a greater risk of injury. Among the various diseases that affect this segment of the body, carpal tunnel syndrome (CTS) is a disease that has a high incidence. Occupational Therapy is a profession that works with functional performance, and CTS is a neuropathy that causes impairment in occupational performance. Thus it is necessary to use some elements in their practice, as a way to evaluate, prevent and / or rehabilitate. The objective of this study was to search in the literature the elements of the Occupational Therapy practice, before the STC. The results were organized into three categories, namely: Studies focusing on evaluation instruments, studies focusing on prevention and studies focusing on intervention / rehabilitation. It was observed that, although the articles have elements of Occupational Therapy, few of them referred to the practice of the profession, although the disease causes damages both in the functional performance and in the social context of the individual.Keywords: Carpal Tunnel Syndrome, Occupational Therapy, Median Nerve.
Intervenções terapêuticas ocupacionais com pacientes renais crônicos no contexto hospitalar: uma análise da prática/ Occupational therapeutic interventions with chronic renal patients in the hospital context: a practice analysis
Authors: Omura Kátia Maki , Alencar Camila de Nazaré , Morais Cavalcante Silvania , Pena Marques Maria do Socorro , Ferreira Campos Camilla 
Published: August 2020

O presente estudo tem como objetivo analisar a prática de estudantes na clínica de nefrologia de um hospital público. Durante o estágio, foram atendidos 8 pacientes. Avaliaram-se componentes de equilíbrio e força, além dos aspectos relacionados ao desempenho das atividades de vida diária e os aspectos emocionais. Posteriormente, foram traçados os planos terapêuticos e nas intervenções foram utilizadas atividades auto-expressivas, motoras e sensoriais e planejamento de um novo papel ocupacional. Conclui-se que foi possível evidenciar a importância do trabalho do terapeuta ocupacional na nefrologia, com melhorias nos componentes de desempenho, aumentando a independência na locomoção e nas atividades de autocuidado. AbstractThe present report aims to analyze the practice of students in the nephrology clinic of a public hospital. During the internship, 8 patients were attended. It was evaluated components of balance and strength, as well as aspects related to the performance of daily life activities and emotional aspects. Subsequently, the therapeutic plans were drawn and in interventions were used expressive, motor and sensorial activities and planning of a new occupational role. It was concluded that it was possible to highlight the importance of the occupational therapist work in nephrology, with improvements in performance components, increasing independence in locomotion and self-care activities.Keywords: Hospital; Chronic renal insufficiency; Occupational therapy.