bluuebunny/crossref_metadata_2025_split huggingface dataset:
WASP-127b: a misaligned planet with a partly cloudy atmosphere and tenuous sodium signature seen by ESPRESSO
Authors: Allart R. , Pino L. , Lovis C. , Sousa S. G. , Casasayas-Barris N. , Zapatero Osorio M. R. , Cretignier M. , Palle E. , Pepe F. , Cristiani S. , Rebolo R. , Santos N. C. , Borsa F. , Bourrier V. , Demangeon O. D. S. , Ehrenreich D. , Lavie B. , Lendl M. , Lillo-Box J. , Micela G. , Oshagh M. , Sozzetti A. , Tabernero H. , Adibekyan V. , Allende Prieto C. , Alibert Y. , Amate M. , Benz W. , Bouchy F. , Cabral A. , Dekker H. , D’Odorico V. , Di Marcantonio P. , Dumusque X. , Figueira P. , Genova Santos R. , González Hernández J. I. , Lo Curto G. , Manescau A. , Martins C. J. A. P. , Mégevand D. , Mehner A. , Molaro P. , Nunes N. J. , Poretti E. , Riva M. , Suárez Mascareño A. , Udry S. , Zerbi F. 
Published: November 2020

Context.The study of exoplanet atmospheres is essential for understanding the formation, evolution, and composition of exoplanets. The transmission spectroscopy technique is playing a significant role in this domain. In particular, the combination of state-of-the-art spectrographs at low- and high-spectral resolution is key to our understanding of atmospheric structure and composition.Aims.We observed two transits of the close-in sub-Saturn-mass planet, WASP-127b, with ESPRESSO in the frame of the Guaranteed Time Observations Consortium. We aim to use these transit observations to study the system architecture and the exoplanet atmosphere simultaneously.Methods.We used the Reloaded Rossiter-McLaughlin technique to measure the projected obliquityλand the projected rotational velocityveq⋅sin(i*). We extracted the high-resolution transmission spectrum of the planet to study atomic lines. We also proposed a new cross-correlation framework to search for molecular species and we applied it to water vapor.Results.The planet is orbiting its slowly rotating host star (veq⋅sin(i*) = 0.53−0.05+0.07km s−1) on a retrograde misaligned orbit (λ= −128.41−5.46+5.60°). We detected the sodium line core at the 9-σconfidence level with an excess absorption of 0.34 ± 0.04%, a blueshift of 2.74 ± 0.79 km s−1, and a full width at half maximum of 15.18 ± 1.75 km s−1. However, we did not detect the presence of other atomic species but set upper limits of only a few scale heights. Finally, we put a 3-σupper limit on the average depth of the 1600 strongest water lines at equilibrium temperature in the visible band of 38 ppm. This constrains the cloud-deck pressure between 0.3 and 0.5 mbar by combining our data with low-resolution data in the near-infrared and models computed for this planet.Conclusions.WASP-127b, with an age of about 10 Gyr, is an unexpected exoplanet by its orbital architecture but also by the small extension of its sodium atmosphere (~7 scale heights). ESPRESSO allows us to take a step forward in the detection of weak signals, thus bringing strong constraints on the presence of clouds in exoplanet atmospheres. The framework proposed in this work can be applied to search for molecular species and study cloud-decks in other exoplanets.
Broadband transmission spectroscopy of HD 209458b with ESPRESSO: evidence for Na, TiO, or both
Authors: Santos N. C. , Cristo E. , Demangeon O. , Oshagh M. , Allart R. , Barros S. C. C. , Borsa F. , Bourrier V. , Casasayas-Barris N. , Ehrenreich D. , Faria J. P. , Figueira P. , Martins J. H. C. , Micela G. , Pallé E. , Sozzetti A. , Tabernero H. M. , Zapatero Osorio M. R. , Pepe F. , Cristiani S. , Rebolo R. , Adibekyan V. , Allende Prieto C. , Alibert Y. , Bouchy F. , Cabral A. , Dekker H. , Di Marcantonio P. , D’Odorico V. , Dumusque X. , González Hernández J. I. , Lavie B. , Lo Curto G. , Lovis C. , Manescau A. , Martins C. J. A. P. , Mégevand D. , Mehner A. , Molaro P. , Nunes N. J. , Poretti E. , Riva M. , Sousa S. G. , Suárez Mascareño A. , Udry S. 
Published: November 2020

Context. The detection and characterization of exoplanet atmospheres is currently one of the main drivers pushing the development of new observing facilities. In this context, high-resolution spectrographs are proving their potential and showing that high-resolution spectroscopy will be paramount in this field.
Aims. We aim to make use of ESPRESSO high-resolution spectra, which cover two transits of HD 209458b, to probe the broadband transmission optical spectrum of the planet.
Methods. We applied the chromatic Rossiter–McLaughin method to derive the transmission spectrum of HD 209458b. We compared the results with previous HST observations and with synthetic spectra.
Results. We recover a transmission spectrum of HD 209458b similar to the one obtained with HST data. The models suggest that the observed signal can be explained by only Na, only TiO, or both Na and TiO, even though none is fully capable of explaining our observed transmission spectrum. Extra absorbers may be needed to explain the full dataset, though modeling approximations and observational errors can also be responsible for the observed mismatch.
Conclusions. Using the chromatic Rossiter–McLaughlin technique, ESPRESSO is able to provide broadband transmission spectra of exoplanets from the ground, in conjunction with space-based facilities, opening good perspectives for similar studies of other planets.
Patient-Reported Outcome Measures (PROMs) – eine Übersicht
Authors: Müller Michael , Biberthaler Peter 
Published: November 2020

ZusammenfassungPROMs sind Fragebogen-Instrumente, mit denen ein Patient kostengünstig und ohne relevanten medizinischen Personalaufwand mittels Selbstevaluation den Funktionellen Status eines Organsystemes erheben kann. In Bereich der Unfallchirurgie und Orthopädie stehen mittlerweile eine Vielfalt an PROMs für verschiedene Fragestellungen zur Verfügung. Mit PROMS kann ein objektives Feedback über den Krankheits-/Heilungsverlauf erstellt werden. Hiermit können individuelle Behandlungsverläufe überwacht werden, aber auch Daten für wissenschaftliche oder gesundheitsökonomische Auswertungen generiert werden.
Thrombozyten im Visier
Authors: Jahn Claus 
Published: November 2020

SummaryIm vorgestellten Fall liegt eine Thrombozytopenie mit einem Wert unter 50 000 Thrombozyten/μl vor. Weder die heilpraktische noch die haus- und fachärztliche Diagnostik können die Ursache zunächst aufdecken. Eine Körperreaktion auf die Einnahme von Ibuprofen führt schließlich zu der richtigen Verdachtsdiagnose.
Gelenk unter Schock
Authors: Corts Magga 
Published: November 2020

SummaryEine 35-jährige, sportliche Patientin zieht sich bei einem Sturz eine komplizierte Radiusfraktur nahe dem Handgelenk zu, worauf sich ein CRPS (Morbus Sudeck) entwickelt. Die Untersuchung zeigt fernab der Traumalokalisation multiple muskuläre und artikuläre Dysbalancen unter anderem mit Rechtstorsion und Seitneigung des ganzen Körpers, aber auch psychischer Belastung. Mit Mobilisations- und Entspannungstechniken, Ausleitungs- und Ernährungstherapie stellen sich rund zwei Monate nach dem Trauma wieder Schmerzfreiheit und eine fast vollständige Gelenkbeweglichkeit ein.
Die Anatomie des retroperitonealen und pelvinen Venensystems
Authors: Hirsch Tobias , Klemenz Albrecht 
Published: November 2020

ZusammenfassungVenenleiden sind nicht auf die Extremitäten beschränkt. Einerseits können Erkrankungen der Beinvenen wie Varikose und Phlebothrombose auch die Venen der Beckenorgane und des Retroperitoneums mit betreffen, andererseits sind pelvine und abdominelle Symptome mitunter auch phlebogen erklärbar. Als Pendant zur chronischen venösen Insuffizienz der Beinvenen hat sich der Begriff des chronischen pelvinen Stauungssyndroms etabliert, der die Komplexität der Störung weder anatomisch noch funktionell adäquat erfasst.Die klinische Diagnostik und die Bildgebung, insbesondere die Duplexsonografie der retroperitonealen Venen, sind erheblich schwieriger als die der Beinvenen. Darüber hinaus sind die Gefäße sehr variantenreich. Die fundierte Kenntnis der Anatomie der pelvinen und retroperitonealen Gefäße ist unersetzlich, um die möglichen Befunde deuten zu können. Das Wissen um die wichtigsten embryologischen Entwicklungsschritte erleichtert das Verständnis pathophysiologischer Mechanismen.
DEAD-Mediated Oxidative Ugi/Aza-Wittig Reaction for the Synthesis of 5-(1,2,3,4-Tetrahydroisoquinolin-1-yl)-1,3,4-oxadi­­azoles Starting from (N-Isocyanimine)triphenylphosphorane
Authors: Ding Ming-Wu , Sun Mei , Zhao Long , Yu Yan-Ling 
Published: November 2020

AbstractA one-pot protocol for the synthesis of 5-(1,2,3,4-tetra­hydroisoquinolin-1-yl)-1,3,4-oxadiazoles via DEAD-mediated oxidative Ugi/aza-Wittig reaction has been developed. The reaction of (N-iso­cyanimine)triphenylphosphorane, carboxylic acids, and N-aryl-1,2,3,4-tetrahydroisoquinolines produced polysubstituted 5-(1,2,3,4-tetra­hydroisoquinolin-1-yl)-1,3,4-oxadiazoles directly in good yields in the presence of DEAD as an oxidant.
Synthesis of 6-Adamantyl-2-pyridone and Reversible Hydrogen Activation by the Corresponding Bis(perfluorophenyl)borane Complex
Authors: Gellrich Urs , Wech Felix , Müller Tizian , Becker Jonathan 
Published: November 2020

AbstractWe herein describe the two-step synthesis of 6-adamantyl-2-pyridone from 1-acetyladamantane. The borane complex derived from 6-adamantyl-2-pyridone and the Piers borane liberates dihydrogen at 60 °C. The reverse reaction, hydrogen activation by the formed pyridonate borane is accomplished under mild conditions. The mechanism of the hydrogen activation is studied by DFT computations.
The East Asian Paradox: An Updated Position Statement on the Challenges to the Current Antithrombotic Strategy in Patients with Cardiovascular Disease
Authors: Kim Hyun Kuk , Tantry Udaya S. , Smith Sidney C. , Jeong Myung Ho , Park Seung-Jung , Kim Moo Hyun , Lim Do-Sun , Shin Eun-Seok , Park Duk-Woo , Huo Yong , Chen Shao-Liang , Bo Zheng , Goto Shinya , Kimura Takeshi , Yasuda Satoshi , Chen Wen-Jone , Chan Mark , Aradi Daniel , Geisler Tobias , Gorog Diana A. , Sibbing Dirk , Lip Gregory Y. H. , Angiolillo Dominick J. , Gurbel Paul A. , Jeong Young-Hoon 
Published: November 2020

AbstractEast Asian patients have reduced anti-ischemic benefits and increased bleeding risk during antithrombotic therapies compared with Caucasian patients. As potent P2Y12 receptor inhibitors (e.g., ticagrelor and prasugrel) and direct oral anticoagulants are commonly used in current daily practice, the unique risk–benefit trade-off in East Asians has been a topic of emerging interest. In this article, we propose updated evidence and future directions of antithrombotic treatment in East Asian patients.
A Review on Safety and Outcomes of Mucous Fistula Refeeding in Neonates
Authors: Ghattaura Harmit , Borooah Manobi , Jester Ingo 
Published: November 2020

Abstract
Introduction The utility of mucous fistula refeeding (MFR) in neonates with short bowel syndrome is widely debated. Our purpose is to review MFR and outline methods, reported complications, and clinical outcomes (survival, weight gain, dependence on parenteral nutrition [PN], and time to enteral autonomy).
Materials and Methods We performed a MEDLINE literature search and reference review from January 1980 to May 2020 for terms (“mucous fistula re-feeding” or “enteral re-feeding”) and neonates. We included studies that utilized conventional MFR in the neonatal period. Non-English language articles were excluded.
Results We identified 11 relevant articles. Internationally, there was no consensus on methods of MFR. A total of 197 neonates underwent MFR. Within a single study, four neonates developed major complications; however, the procedure was well tolerated without major complications in 10 of the 11 studies. A mortality of nine patients during MFR highlights the burden of disease within the study population; however, of these, only one was directly attributable to MFR. Minor complications were seldom quantified. Three studies demonstrated a higher rate of weight gain and shorter PN support versus controls. Neonates who underwent MFR had lower chance of anastomotic leak and quicker progression to full feed after reversal versus controls. The influence of microorganisms in MFR was only investigated in one study.
Conclusion Current evidence suggests benefits of MFR; however, an international consensus is yet to be reached on the optimal method. A large prospective study investigating the influence of MFR on the enteric system is required.
Double Trouble: A Rare Association between Chronic Total Occlusion of the Left Main Coronary Artery and Colonic Malignancy
Authors: Sarojadevi Ashida Thulaseedharan , Arasappa Arunkumar , Eugin Priscilla Rubavathy , Ramaraj Krishna Prabu , Fernando Anto Mariadoss 
Published: November 2020

AbstractEmerging evidence has shown an association between cardiovascular (CV) disease and cancer due to shared risk factors and biological mechanisms especially chronic inflammation. The objective of this case report is to highlight the association between these two lethal diseases and the challenges in the management of coronary artery disease in patients with coexisting malignancy.A 65-year-old nonsmoker, nondiabetic, and normotensive male presented with a history of abdominal pain and significant weight loss. Colonoscopy and biopsy showed adenocarcinoma of the ascending colon, and he was planned for right hemicolectomy. Electrocardiogram exercise stress test performed as a part of preoperative evaluation was strongly positive. Coronary angiography was suggestive of Chronic total occlusion of the left main coronary artery. Though the syntax score was intermediate, coronary artery bypass grafting was decided as the revascularization strategy as he needed early surgery for the colonic malignancy. A month later, he underwent right hemicolectomy.Clinicians should be aware of the association between CV disease and cancer as they are likely to face similar situations where both coexist. Understanding the connections between heart disease and cancer will help to formulate combined preventive guidelines.
Reduced thermal tolerance in a coral carrying CRISPR-induced mutations in the gene for a heat-shock transcription factor
Authors: Cleves Phillip A. , Tinoco Amanda I. , Bradford Jacob , Perrin Dimitri , Bay Line K. , Pringle John R. 
Published: November 2020

Significance
Coral reefs are biodiversity hotspots of great ecological, economic, and aesthetic importance. Their global decline due to climate change and other stressors has increased the urgency of understanding the molecular bases of corals’ responses to stress. Analyses of coral genomes and gene-expression patterns have identified many genes that may be important in stress resistance, but rigorous testing of their function will require the analysis of appropriate mutants. Here, we used CRISPR technology to show that mutational loss of a putative regulator of gene expression in response to heat stress indeed produced a loss of heat tolerance. Such use of CRISPR to generate mutations in corals should illuminate many aspects of coral biology and, thus, help to guide conservation efforts.
Stac protein regulates release of neuropeptides
Authors: Hsu I-Uen , Linsley Jeremy W. , Zhang Xiaoli , Varineau Jade E. , Berkhoudt Drew A. , Reid Lilly E. , Lum Miranda C. , Orzel Allison M. , Leflein Ari , Xu Haoxing , Collins Catherine A. , Hume Richard I. , Levitan Edwin S. , Kuwada John Y. 
Published: November 2020

SignificanceMany neurons release neuropeptides as well as classical neurotransmitters. Neuropeptides often regulate neural circuits controlling behaviors such as emotional behaviors. However, how neuropeptide release is regulated is not well-understood. We identified aDrosophilagene,Dstac, that is similar to a vertebrate gene that regulates voltage-dependent calcium channels in skeletal muscles and found that it is active in muscles and a subset of neurons, including motor neurons. Using live imaging, electrophysiology, and genetic manipulations, we found that Dstac localizes to motor synapses with muscles and regulates the voltage response of calcium channels and the release of neuropeptides. Since Stac proteins are found in neurons in the vertebrate CNS, they may also be regulators of neuropeptide release in the vertebrate brain.
Observation of non-Hermitian topology and its bulk–edge correspondence in an active mechanical metamaterial
Authors: Ghatak Ananya , Brandenbourger Martin , van Wezel Jasper , Coulais Corentin 
Published: November 2020

Significance
In recent years, the mathematical concept of topology has been used to predict and harness the propagation of waves such as light or sound in materials. However, these advances have so far been realized in idealized scenarios, where waves do not attenuate. In this research, we demonstrate that topological properties of a mechanical system can predict the localization of waves in realistic settings where the energy can grow and/or decay. These findings may lead to strategies to manipulate waves in unprecedented fashions, for applications in vibration damping, energy harvesting, and sensing technologies.
Basic colour terms in Modern Greek: Twelve terms including two blues
Authors: Coventry Kenny , Mitsakis Christos , Davies Ian , Jover Julio Lillo , Androulaki †Anna , Gômez-Pestaña Natalia 
Published: November 2020

AbstractWe describe an investigation of Modern Greek colour terms intended to establish its set of basic colour terms (BCTs). Pilot work suggested that Greek had terms for each of the Berlin & Kay (1969) eleven ‘universal categories’. These terms, plus [γalázjo] “light blue”, were the most frequent terms in Greek texts. Four naming studies with varying stimuli (Munsell, Color-aid and NCS), lighting (daylight, illuminant C and fluorescent), instructions (no restriction on terms or only essential terms), and informants (bilingual Greek-English students and monolingual Greek speakers from Crete) were carried out. Measures of basicness included frequency, consistency and consensus of use, naming time and ‘necessity’. The results supported the analysis of texts, suggesting that Greek has twelve BCTs, including two terms for blue. The ranges of the two blue terms differ mainly in lightness, and this division is similar to the equivalent divisions in Russian and Turkish. However, the positions of the best examples vary across the three languages presenting difficulties for a common account of the origins of the additional term. The use of BCTs was reasonably stable across variations in methods, stimuli, lighting and informants, suggesting that field studies with limited control over these variables may nevertheless be able to identify BCTs.
A Grammar Inclusion Hypothesis of child language variation
Authors: Tzakosta Marina , Revithiadou Anthi 
Published: November 2020

AbstractThis paper examines variation in language development based on production data from three Greek-speaking children. Variation suggests that children employ more than one grammar during the acquisition process. This naturally raises the question of how ‘unwanted’ grammars gradually give way to the one that relates to the adult/target grammar. To account for variation, we implement partial ordering (Anttila 1997a, 1997b) to Tzakosta’s (2004) Multiple Parallel Grammars model of language development. More specifically, we propose that, in the intermediate stage of acquisition, constraint permutation of the initial Markedness » Faithfulness ranking leads to grammar explosion. We view the resulting grammars as partial orders that contain sets of totally ranked grammars (subgrammars). The pivotal claim is that only those subgrammars that are typologically closer to the target one will eventually survive. This is stated as the Grammar Inclusion Hypothesis. The theoretical gain of the proposed model is that it provides a principled basis to define developmental paths and also to distinguish between smart and non-smart paths. The latter are partial orders that do not contain the target grammar as a total order and hence are doomed to extinction. The former, on the other hand, are partial orders that contain at least one total order that relates to the target grammar and, crucially, connect the running state of acquisition with the end state of language development. Our hypothesis finds empirical support by both inter-child and intra-child language acquisition data.
Breather solutions of the cubic Klein–Gordon equation
Authors: Scheider Dominic 
Published: November 2020

Abstract
We obtain real-valued, time-periodic and radially symmetric solutions of the cubic Klein–Gordon equation

∂

t

2

U
−
Δ
U
+

m

2

U
=
Γ

(

x

)

U

3

on

R
×

R

3

,

which are weakly localized in space. Various families of such ‘breather’ solutions are shown to bifurcate from any given nontrivial stationary solution. The construction of weakly localized breathers in three space dimensions is, to the author’s knowledge, a new concept and based on the reformulation of the cubic Klein–Gordon equation as a system of coupled nonlinear Helmholtz equations involving suitable conditions on the far field behavior.
Porcine lung phantom-based validation of estimated 4D-MRI using orthogonal cine imaging for low-field MR-Linacs
Authors: Rabe Moritz , Paganelli Chiara , Riboldi Marco , Bondesson David , Jörg Schneider Moritz , Chmielewski Thomas , Baroni Guido , Dinkel Julien , Reiner Michael , Landry Guillaume , Parodi Katia , Belka Claus , Kamp Florian , Kurz Christopher 
Published: November 2020

Abstract
Real-time motion monitoring of lung tumors with low-field magnetic resonance imaging-guided linear accelerators (MR-Linacs) is currently limited to sagittal 2D cine magnetic resonance imaging (MRI). To provide input data for improved intrafractional and interfractional adaptive radiotherapy, the 4D anatomy has to be inferred from data with lower dimensionality. The purpose of this study was to experimentally validate a previously proposed propagation method that provides continuous time-resolved estimated 4D-MRI based on orthogonal cine MRI for a low-field MR-Linac. Ex vivo porcine lungs were injected with artificial nodules and mounted in a dedicated phantom that allows for the simulation of periodic and reproducible breathing motion. The phantom was scanned with a research version of a commercial 0.35 T MR-Linac. Respiratory-correlated 4D-MRI were reconstructed and served as ground truth images. Series of interleaved orthogonal slices in sagittal and coronal orientation, intersecting the injected targets, were acquired at 7.3 Hz. Estimated 4D-MRI at 3.65 Hz were created in post-processing using the propagation method and compared to the ground truth 4D-MRI. Eight datasets at different breathing frequencies and motion amplitudes were acquired for three porcine lungs. The overall median (95

t
h

percentile) deviation between ground truth and estimated deformation vector fields was 2.3 mm (5.7 mm), corresponding to 0.7 (1.6) times the in-plane imaging resolution (3.5 × 3.5 mm2). Median (95

t
h

percentile) estimated nodule position errors were 1.5 mm (3.8 mm) for nodules intersected by orthogonal slices and 2.1 mm (7.1 mm) for nodules located more than 2 cm away from either of the orthogonal slices. The estimation error depended on the breathing phase, the motion amplitude and the location of the estimated position with respect to the orthogonal slices. By using the propagation method, the 4D motion within the porcine lung phantom could be accurately and robustly estimated. The method could provide valuable information for treatment planning, real-time motion monitoring, treatment adaptation, and post-treatment evaluation of MR-guided radiotherapy treatments.