bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construction of circRNA-based ceRNA Network to Reveal the Role of circRNAs in the Progression and Prognosis of Hepatocellular Carcinoma
Authors: Deng Rong , Cui XiaoHan , Dong Yuxiang , Tang Yanqiu , Tao Xuewen , Wang Shuyu , Wang Jin-cheng , Chen Lin 
Published: October 2020

Abstract
Background: Circular RNAs (circRNAs) are now under hot discussion as novel promising bio-markers for patients with hepatocellular carcinoma. The purpose of our study is to identify several competing endogenous RNAs (ceRNAs) networks related to the prognosis and progression of hepatocellular carcinoma, and to further investigate the mechanism of their influence on tumor progression.Methods: First, we obtained gene expression data related to liver cancer from the TCGA database (http://www.portal.gdc.cancer.gov/), including miRNA-seq, RNA-seq and clinical information. A co-expression network was constructed through the WGCNA software package in R software, with the purpose of identifying important microRNAs (miRNAs) and messenger RNAs (mRNAs) related to liver cancer. The DEmRNAs in the key module were analyzed with DAVID (https://david.ncifcrf.gov/summary.jsp) to perform functional enrichment analysis including Kyoto Encyclopedia of Genes and Genomes (KEGG) and gene ontology (GO). The data of miRNA expression and clinical information downloaded from TCGA was utilized for survival analysis to detach the prognostic value of the DEmiRNAs of the key module. Results：201 DEmiRNAs and 3783 DEmRNAs were finally identified through differential expression analysis. The co-expression networks of DEmiRNA and DEmRNA were constructed by using WGCNA. Further analysis confirmed 4 miRNAs in the most significant module (blue module) were associated with the OS of patients with liver cancer, including hsa-miR-92b-3p, hsa-miR-122-3p, hsa-miR-139-5p and hsa-miR-7850-5p. DAVID was used for functional enrichment analysis of 286 co-expressed mRNAs. The Gene Ontology (GO) analysis results showed that the top enriched GO terms were oxidation-reduction process, extracellular exosome and iron ion binding. In Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, the top 3 enriched terms included metabolic pathways, fatty acid degradation and valine, leucine and isoleucine degradation. In addition, we corssed the miRNA-mRNA interactions prediction results with the differentially expressed and prognostic mRNAs, and found that hsa-miR-92b-3p can be related to cytoplasmic polyadenylation element binding protein 3 (CPEB3) and Acyl-CoA Dehydrogenase Long Chain (ACADL). By overlapping the data of predicted circRNAs by circBank and differentially expressed circRNAs of GSE94508, we screened has_circ_0077210 as the upstream regulatory molecule of hsa-miR-92b-3p. Hsa_circ_0077210/hsa-miR-92b-3p/CPEB3&ACADL were validated in hepatic cell carcinoma (HCC) tissues and human protein atlas (HPA) database.Conclusion: Our research provides a mechanistic elucidation of the unknown ceRNA regulatory network in HCC. Hsa_circ_0077210 might serve as an important biomarker to promote the occurrence and development of HCC.
Label-Free Proteomic Analysis Uncovers SMC1A Expression is Down-regulated in AUB-E Patients
Authors: Jia Yingxian , Luo Jie , Lan Yibing , Li Chunming , Ma Linjuan , Zhu Xiaoming , Ruan Fei , Zhou Jianhong 
Published: October 2020

Abstract
Background: While heavy menstrual bleeding (HMB) is a prevalent symptom among women with abnormal uterine bleeding caused by the primary endometrial disorder (AUB-E) seeking gynecologic care, the primary endometrial disorder remains poorly understood. Methods: 5 human endometrial samples from women with AUB-E to healthy women and the age-matched healthy women were selected. Proteins from the samples were analyzed by a linear ion trap (LTQ)-Orbitrap Elite mass spectrometer based label-free proteomic approach. Results: A total of 2138 protein groups were quantified under highly stringent criteria with a false discovery rate of < 1% for protein groups, and 317 proteins were significantly changed between the two groups. Combined the results from enriched analysis and protein−protein interaction network analysis showed that the down-regulation of structural maintenance of chromosomes protein 1 A (SMC1A) in AUB-E patients. validated by western blot and immunohistochemistry.Conclusion: The results indicated novel evidence that SMC1A change of the endometrium in women with AUB-E may be associated with the key biological mechanisms (such as cell proliferation) underlying human endometrial remodeling.
A Randomized Study on the Bioequivalence of Desloratadine in Healthy Chinese Subjects and the Association of Different Metabolic Phenotypes With UGT2B10 and CYP2C8 Genotypes
Authors: Niu Suping , Li Yan , Dong Wenliang , Xia Lin , Shen Tiantian , Wang Jiaxue , Wang Qian , Zhang Tan , Zhang Minjie , Liu Gang , Guo Danjie , Fang Yi 
Published: October 2020

Background:
Desloratadine is a drug with a phenotypic polymorphism in metabolism and has been
approved for use in many countries to treat allergic diseases. CYP2C8 and UGT2B10 are metabolic enzymes,
which may be involved in the metabolism of desloratadine.

Objective:
This study aimed to demonstrate bioequivalence between the test product (desloratadine tablet) and
the reference product AERIUS (5mg), both orally administered. And the role of UGT2B10 and CYP2C8 genotypes
in healthy Chinese subjects with different Desloratadine metabolic phenotypes was examined.

Methods:
It was a randomized, open-label, and four-sequence, single-dose crossover study conducted on 56
healthy Chinese subjects. The pharmacokinetics (PK) and safety of the test and reference Desloratadine products
were compared. UGT2B10 and CYP2C8 genotypes were determined by the TaqMan assay using genomic
DNA. Multiple linear regression was applied to analyze the correlation between genotypes and the metabolic ratio.

Results:
The mean serum concentration-time curves of desloratadine and 3-OH-desloratadine were similar between
the test product and the reference product. For the PK similarity comparison, the 90% CIs for the geometric
mean ratios of Cmax, AUC0-t, and AUC0-∞ of desloratadine and 3-OH-desloratadine of test and reference product
were completely within 80-125%. None of all 56 subjects had serious adverse events. Only 2 subjects were
poor-metabolizers in 56 healthy subjects. There was no significant correlation between investigated genotypes
of CYP2C8 and UGT2B10 and the metabolic ratio.

Conclusion:
The test desloratadine tablet was bioequivalent to the reference product. No direct relationship between
CYP2C8 and UGT2B10 genotypes and desloratadine metabolic ratio was identified.
The Development of the Vital Signs Tele-monitoring System for the Elderly by Using ‘UML’ Language and the Interoperability Standard ‘Continua’
Authors: Mansouri Sofiene 
Published: October 2020

Aims:
We aim to develope a system allowing the telemonitoring of the elderly health status. Medical telemonitoring can make life easy and safe for elderly. The goal of this project is the development of a medical telemonitoring application.

Background:
Medical telemonitoring can make life easy and safe for elderly.

Objective:
The goal of this project is the development of a medical telemonitoring application.

Methods:
In this paper we exposed the different steps of the developing of a medical telemonitoring system designed for the elderly. We studied the medical needs and the system specifications. We used the UML language. Then we detailed the designed system with a total respect to the standard for the interoperability of connected medical equipment, Continua. We presented printed screens of the realized interfaces.

Results:
We realized an application based on web development, more specifically development of a management application for medical telemonitoring.

Conclusion:
In terms of perspectives, we aim to integrate security protocols in the developed system, integrate the data sent from the sensors into an E, H & R (HER) and send the patient file to a H, I & S (HIS).
Campus Engagement: Faculty Recognition and the Library's Role
Authors: Kelly Safin  , Renee Kiner  
Published: October 2020

As faculty librarians on a regional campus of a research university, attending meetings is one way we stay connected to our faculty colleagues. On several occasions at these events, faculty commented about a need for their work outside the classroom to be recognized in a more public forum. As we are always looking for ways to serve and engage with our campus, we considered if the library could somehow meet this need. Providing a showcase for faculty accomplishments could potentially help faculty connect with each other, show students examples of research and scholarship by their instructors, and give us another opportunity to talk with faculty about how we can support them and their students. From there, a Faculty Recognition Event hosted by our library took shape. Early in this process, we reached out to Academic Affairs, as this office is among the most engaged with the teaching and scholarship of faculty. Through this partnership, we built a framework for organizing the event: types of work to feature, ways to get the information, when and where the event should take place, and more. Although the process was not always smooth, the first event met our expectations of highlighting faculty scholarship, service, presentations, and grants or other awards. Hosting a casual lunchtime event featuring this work presented outreach opportunities we may not have otherwise had. The lessons learned from the first attempt informed the approach we took to plan a second, more well-attended event.
A Recursive Model of the Spread of COVID-19: Modelling Study
Authors: Ilyin Sergey O 
Published: October 2020

Background
The major medical and social challenge of the 21st century is COVID-19, caused by the novel coronavirus SARS-CoV-2. Critical issues include the rate at which the coronavirus spreads and the effect of quarantine measures and population vaccination on this rate. Knowledge of the laws of the spread of COVID-19 will enable assessment of the effectiveness and reasonableness of the quarantine measures used, as well as determination of the necessary level of vaccination needed to overcome this crisis.

Objective
This study aims to establish the laws of the spread of COVID-19 and to use them to develop a mathematical model to predict changes in the number of active cases over time, possible human losses, and the rate of recovery of patients, to make informed decisions about the number of necessary beds in hospitals, the introduction and type of quarantine measures, and the required threshold of vaccination of the population.

Methods
This study analyzed the onset of COVID-19 spread in countries such as China, Italy, Spain, the United States, the United Kingdom, Japan, France, and Germany based on publicly available statistical data. The change in the number of COVID-19 cases, deaths, and recovered persons over time was examined, considering the possible introduction of quarantine measures and isolation of infected people in these countries. Based on the data, the virus transmissibility and the average duration of the disease at different stages were evaluated, and a model based on the principle of recursion was developed. Its key features are the separation of active (nonisolated) infected persons into a distinct category and the prediction of their number based on the average duration of the disease in the inactive phase and the concentration of these persons in the population in the preceding days.

Results
Specific values for SARS-CoV-2 transmissibility and COVID-19 duration were estimated for different countries. In China, the viral transmissibility was 3.12 before quarantine measures were implemented and 0.36 after these measures were lifted. For the other countries, the viral transmissibility was 2.28-2.76 initially, and it then decreased to 0.87-1.29 as a result of quarantine measures. Therefore, it can be expected that the spread of SARS-CoV-2 will be suppressed if 56%-64% of the total population becomes vaccinated or survives COVID-19.

Conclusions
The quarantine measures adopted in most countries are too weak compared to those previously used in China. Therefore, it is not expected that the spread of COVID-19 will stop and the disease will cease to exist naturally or owing to quarantine measures. Active vaccination of the population is needed to prevent the spread of COVID-19. Furthermore, the required specific percentage of vaccinated individuals depends on the magnitude of viral transmissibility, which can be evaluated using the proposed model and statistical data for the country of interest.
Reducing Alert Fatigue by Sharing Low-Level Alerts With Patients and Enhancing Collaborative Decision Making Using Blockchain Technology: Scoping Review and Proposed Framework (MedAlert)
Authors: Wan Paul Kengfai , Satybaldy Abylay , Huang Lizhen , Holtskog Halvor , Nowostawski Mariusz 
Published: October 2020

Background
Clinical decision support (CDS) is a tool that helps clinicians in decision making by generating clinical alerts to supplement their previous knowledge and experience. However, CDS generates a high volume of irrelevant alerts, resulting in alert fatigue among clinicians. Alert fatigue is the mental state of alerts consuming too much time and mental energy, which often results in relevant alerts being overridden unjustifiably, along with clinically irrelevant ones. Consequently, clinicians become less responsive to important alerts, which opens the door to medication errors.

Objective
This study aims to explore how a blockchain-based solution can reduce alert fatigue through collaborative alert sharing in the health sector, thus improving overall health care quality for both patients and clinicians.

Methods
We have designed a 4-step approach to answer this research question. First, we identified five potential challenges based on the published literature through a scoping review. Second, a framework is designed to reduce alert fatigue by addressing the identified challenges with different digital components. Third, an evaluation is made by comparing MedAlert with other proposed solutions. Finally, the limitations and future work are also discussed.

Results
Of the 341 academic papers collected, 8 were selected and analyzed. MedAlert securely distributes low-level (nonlife-threatening) clinical alerts to patients, enabling a collaborative clinical decision. Among the solutions in our framework, Hyperledger (private permissioned blockchain) and BankID (federated digital identity management) have been selected to overcome challenges such as data integrity, user identity, and privacy issues.

Conclusions
MedAlert can reduce alert fatigue by attracting the attention of patients and clinicians, instead of solely reducing the total number of alerts. MedAlert offers other advantages, such as ensuring a higher degree of patient privacy and faster transaction times compared with other frameworks. This framework may not be suitable for elderly patients who are not technology savvy or in-patients. Future work in validating this framework based on real health care scenarios is needed to provide the performance evaluations of MedAlert and thus gain support for the better development of this idea.
Digital Interventions for Depression and Anxiety in Older Adults: Protocol for a Systematic Review
Authors: Riadi Indira , Kervin Lucy , Teo Kelly , Churchill Ryan , Cosco Theodore D 
Published: October 2020

Background
There is a high prevalence of older adults experiencing depression and anxiety. In response to heightened demands for mental health interventions that are accessible and affordable, there has been a recent rise in the number of digital mental health interventions (DMHIs) that have been developed and incorporated into mental health treatments. Digital interventions are promising in their ability to provide researchers, medical practitioners, and patients with personalized tools for assessing behavior, consultation, treatment, and care that can be used remotely. Reviews and meta-analyses have shown the benefits of DMHIs for the treatment and prevention of depression, anxiety, and other mental illnesses, but there is still a lack of studies that focus on the benefits and use of DMHIs in the older population.

Objective
The aim of this systematic review is to investigate the current evidence for the effect of technology-delivered interventions, such as smartphone/tablet applications, remote monitoring and tracking devices, and wearable technology, for the treatment and prevention of depression and anxiety in adults older than 50 years.

Methods
The academic databases SCOPUS, PsycINFO, AgeLine (EBSCO), and Medline (PubMed) will be searched from January 1, 2010, to the date of search commencement to provide a review of existing randomized controlled trial studies. The search will include 3 key concepts: “older adults,” “digital intervention,” and “depression/anxiety.” A set of inclusion criteria will be followed during screening by two reviewers. Data will be extracted to address aims and objectives of the review. The risk of bias for each study will be determined using appropriate tools. If possible, a random-effects meta-analysis will be performed, and the heterogeneity of effect sizes will be calculated.

Results
Preliminary searches were conducted in September 2020. The review is anticipated to be completed by April 2021.

Conclusions
The data accumulated in this systematic review will demonstrate the potential benefits of technology-delivered interventions for the treatment of depression and anxiety disorders in older adults. This review will also identify any gaps in current studies of aging and mental health interventions, thereby navigating a way to move forward and paving the path to more accessible and user-friendly digital health interventions for the diverse population of older adults.

Trial Registration
PROSPERO International Prospective Register of Systematic Reviews CRD42020192532; https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020192532

International Registered Report Identifier (IRRID)
PRR1-10.2196/22738
Anxiety and Suicidal Thoughts During the COVID-19 Pandemic: Cross-Country Comparative Study Among Indonesian, Taiwanese, and Thai University Students
Authors: Pramukti Iqbal , Strong Carol , Sitthimongkol Yajai , Setiawan Agus , Pandin Moses Glorino Rumambo , Yen Cheng-Fang , Lin Chung-Ying , Griffiths Mark D , Ko Nai-Ying 
Published: October 2020

Background
The COVID-19 pandemic has negatively affected the mental health of university students.

Objective
This study examined the psychological responses toward COVID-19 among university students from 3 countries—Indonesia, Taiwan, and Thailand.

Methods
We used a web-based, cross-sectional survey to recruit 1985 university students from 5 public universities (2 in Indonesia, 1 in Thailand, and 1 in Taiwan) via popular social media platforms such as Facebook, LINE, WhatsApp, and broadcast. All students (n=938 in Indonesia, n=734 in Thailand, and n=313 in Taiwan) answered questions concerning their anxiety, suicidal thoughts (or sadness), confidence in pandemic control, risk perception of susceptibility to infection, perceived support, resources for fighting infection, and sources of information in the context of the COVID-19 pandemic.

Results
Among the 3 student groups, Thai students had the highest levels of anxiety but the lowest levels of confidence in pandemic control and available resources for fighting COVID-19. Factors associated with higher anxiety differed across countries. Less perceived satisfactory support was associated with more suicidal thoughts among Indonesian students. On the other hand, Taiwanese students were more negatively affected by information gathered from the internet and from medical staff than were Indonesian or Thai students.

Conclusions
Our findings suggest that health care providers in Thailand may need to pay special attention to Thai university students given that high levels of anxiety were observed in this study population. In addition, health care providers should establish a good support system for university students, as the results of this study indicate a negative association between support and suicidal thoughts.
Economic burden of readmission due to postoperative cerebrospinal fluid leak in Chinese patients
Authors: Wu Shuqing , Cui Xin , Zhang Shaoyu , Tian Wenqi , Liu Jiazhen , Wu Yiqing , Wu Man , Han Yi 
Published: October 2020

Aim:
This real-world data study investigated the economic burden and associated factors of readmissions for cerebrospinal fluid leakage (CSFL) post-cranial, transsphenoidal, or spinal index surgeries.
Methods:
Costs of CSFL readmissions and index hospitalizations during 2014–2018 were collected. Readmission cost was measured as absolute cost and as percentage of index hospitalization cost. Factors associated with readmission cost were explored using generalized linear models.
Results:
Readmission cost averaged US$2407–6106, 35–94% of index hospitalization cost. Pharmacy costs were the leading contributor. Generalized linear models showed transsphenoidal index surgery and surgical treatment for CSFL were associated with higher readmission costs.
Conclusion:
CSFL readmissions are a significant economic burden in China. Factors associated with higher readmission cost should be monitored.
(De)Composições do corpo físico e social: a emergência do zumbi na ficção norte-americana contemporânea
Authors: Gomes Anderson Soares 
Published: October 2020

Um dos mais populares monstros do período contemporâneo, o zumbi se configura como significante privilegiado para captar as ansiedades do início do século XXI. Surgido nas narrativas de viagem de exploradores do Haiti no início do século XX, e depois adquirindo status de principal criatura do cinema de horror da atualidade, o zumbi vem servindo como alegoria para autores da literatura norte-americana tematizarem discussões sobre os limites da civilização, do corpo, e da própria noção de self. O presente trabalho se concentra em dois romances essenciais para melhor compreender o zumbi como símbolo da (de)composição do mundo contemporâneo. O primeiro é Zone One, de Colson Whitehead, que mostra a tentativa de reconstrução da cidade de Nova York após a infestação da cidade pelas criaturas. O romance também apresenta uma variação bastante peculiar e complexa do zumbi: o straggler. A segunda obra aqui discutida é Guerra Mundial Z, de Max Brooks, que traça um mosaico de personagens e narra os acontecimentos de uma guerra contra zumbis que praticamente extinguiu a humanidade. Os dois romances discutem, em suas narrativas, como o zumbi problematiza noções de alteridade por ser uma criatura despida de subjetividade, mas que ainda assim preserva traços humanos. Além disso, os mortos-vivos servem como exemplo máximo para o conceito de "estranho" (unheimlich), como analisado por Freud. Assim sendo, este trabalho pretende investigar a ascensão do zumbi como metáfora do momento atual na literatura norte-americana contemporânea e discutir como esse monstro tão assustador serve como representação do zeitgeist deste início de século.