bluuebunny/crossref_metadata_2025_split huggingface dataset:
INTEGRASI HUNIAN DALAM TOD UNTUK MENGATASI PERMASALAHAN TRANSIT KAWASAN PASAR LAMA, TANGERANG
Authors: Tanudjaja Oscar , Srinaga Felia , Mensana Alvar 
Published: June 2020

Title: Residential Integration in TOD to Overcome the Transit Problem in Pasar Lama Area, Tangerang
The Pasar Lama (Old Town Market) area is known as a highly developing area in the city of Tangerang. This area facilitated with a commuter train station used by people commuted from Tangerang to Jakarta in daily basis – both for transitting and shopping purposes. Tangerang Station is the main train station for commuters’ from-and-to Jakarta; therefore, urban issues arise in the main urban nodes of the area, specifically the main boulevard near the station and the market. Issues such as transportation traffic, pedestrian congestion, informal street-vendors activities, and the arrangement of residential areas are major concern that needs to be addressed in the purpose of creating a good urban public space in the region. The solution to overcome this problem is to apply a concept for a TOD (Transit Oriented Development). TOD is a sustainable transportation system approach that provides accessibility and alternative modes of transportation. With the implementation of TOD in the transit station area, it is expected that the entire Pasar Lama area will be developed and created a good urban public space. This research study aims to answer several research questions, for instance: how does the concept of the TOD is able to integrate a residential program into the development and create a successful an urban public space as a transit area in the area of Pasar Lama, Tangerang. This research begins with context analysis based on several theories about urban dimension, human scale and key factors of a TOD. Precedent studies and observations on surrounding site, serve as references in analyzing and proposing draft concepts for this particular neighborhood. This research study will have an outcome in the form of design concept proposal that allow TOD to incorporate residential, parking, commercial, and open space as one district to revitalize the congested neighborhood in the Pasar Lama area, Tangerang.
KOTA PROBOLINGGO: DARI PANOPTIKON KE FRAGMENTED POWER
Authors: Hidayat Anas , Widriyakara Y.A. 
Published: June 2020

Title: The City of Probolinggo: From Panopticon to Fragmented Power
The City of Probolinggo, was designed during the Dutch colonial administration. It is very clearly shows the pattern of the city as a city-scale panopticon, as it is mentioned in the theory of Jeremy Bentham. The city layout could be explained as follow: the resident's office (regional leader) becomes the center (as well as the supervisor) of a linear and straight government environment from the south (Jalan Raya Pos) to the north (Probolinggo Lama port). The Probolinggo resident office can spatially "over look" the area to the direction of north, starting from the square, then train station, then the warehouses until it ends at the port located in the Madura Strait. The power of the panopticon is not just a matter of political space, but also includes it as a defense space, economic space, social space and even cultural space. When compared with current conditions, so now the power has changed the pattern from the centralized to more fragmented, as Richard Rorty's understanding of 'the breaking of the great mirror of the universe'.There is no longer a dominant center (and at the same time overseeing), all have their own strength to show themselves. Central to the current administration is the office of the mayor of Probolinggo, whose position has shifted from the old resident's office (now the Kodim 0820 headquarters) to the west. The area of the square was then only a mere symbolic area. The train station has turned into a means of transportation, especially for humans, it is no longer a semi-passive international commodity transporter, its relationship with the port has also been severed. The weakness, between the elements of the city to be like not connected, there is no synergy between one another.
STREETSCAPE SEBAGAI PEMBENTUK KARAKTER KAWASAN Studi Kasus : Jalan Rungkut Madya Surabaya
Authors: Utomo Heru Prasetiyo , Mutia Fairuz 
Published: June 2020

Title: Streetscape as a Formation of Area Character in Rungkut Madya Street Surabaya
Urban areas are always dynamic where some regions develop more rapidly than other regions. Rungkut Madya street as a collector road has undergone many changes along with the construction of MERR road and OERR road plans by the Surabaya City Government and East Java Provincial Government. There is no integration of area arrangement at Rungkut Madya street that is able to characterize and provide visual - spatial quality that is able to improve the physical condition of the area. Meanwhile landscape quality (streetscape) needs to be considered in road design, referring to good streetscape criteria (Moughtin, 1999). The research method chosen is exploratory and descriptive. The description is focused on the authenticity of the shape and character of the area in Rungkut Madya street to explore existing city elements. Data collection more describes the conditions of reality and potential on Rungkut Madya street which are arranged in a mapping. Furthermore, these results are explored using Character Appraisal Research. The analysis is carried out qualitatively and supported by simple quantitative analysis. This research is expected to be able to produce an urban treatment that can identify the quality of the environment to be a special criterion in improving the quality of the environment and the identity of the Rungkut Madya street as an education, trade and service area.
A cost-effective redundant communication system for improving the reliability of a flood early warning system
Authors: López E. P. , Vionnet C. A. , Villarreal D. , Contini G. , Veizaga E. , Ferreira C. G. 
Published: June 2020

Abstract
All early flood warning systems (FEWS) work with gauges and communications systems to collect and distribute hydro-meteorological measurements in real-time. The objective is to allow the authorities to take action before the flood reaches critical places. The FEWS of the lower Salado River basin, Argentina, were established after the flood of Santa Fe city in 2003. Frequent loss of information due to communication problems with the repository site increases the operational vulnerability of the network. First, the document analyses the flood frequency of the region using known statistical distributions. Then, it offers a low-cost solution to the loss of information problem based on an interface that transmits in parallel the network data through an electronic bypass without interfering with the FEWS satellite communication system. The tests carried out along three stations show the interface proved efficient in transmitting data via WiFi or mobile communications in real-time. The results establish a one-to-one data correspondence when the satellite system and the redundant system are active. The interface is based on low-cost single-board computers and routers. The variety of commercial sensors tested makes the developed interface portable to similar situations, and the savings achieved – maintenance cost – are significant.
UV-assisted desalination of seawater using titanium dioxide nanotube doped polyether block amide membrane
Authors: Nigiz F. U. , Kibar M. E. 
Published: June 2020

Abstract
In this study, a UV-assisted desalination system was prepared with a non-porous TiO2-doped Pebax 1657 membrane. The membranes were characterized and desalination tests were performed. The effects of UV light and TiO2 ratio on the performance of desalination were investigated. According to the results, TiO2 incorporation increased the membrane hydrophilicity, increased the membrane swelling values, enhanced the membrane flux and improved the salt rejection. Moreover, UV treatment has a positive effect on desalination performance. The best improvement was achieved in the results of 10 wt.% TiO2-doped membrane. It was found that the flux value of the UV-treated membrane having 10 wt.% TiO2 concentration was 8.2 kg/m2·h and the salt rejection value was 99.97%. It was found that the prepared membrane showed excellent desalination performance.
Efficient electrochemical detection of geosmin in environmental waters
Authors: Li Jiawei , Xue Qiang , Chen Tao , Wang Zhiwei , Liu Ting , Liu Yuehua , Shan Xiaohan 
Published: June 2020

Abstract
A new electrochemical sensor based on molecular imprinting technology was developed, for rapid and sensitive detection of the odorous substance geosmin (GSM) in water. In this method, the molecularly imprinted membrane was successfully modified on the surface of the glassy carbon electrode (GCE) using the electrochemical deposition method. In the presence of the target analyte (geosmin), the target analyte occupies the detection site and the detection signal will attenuate. As the concentration of the target analyte increases, the attenuation of the electrical signal becomes more pronounced. This sensor can quantitatively detect geosmin at concentrations as low as 5 ng/L, which is currently the lowest limit of detection (LOD) for GSM detection by an electrochemical sensor in reported studies. The modified GCE provided an analytical curve for GSM detection in the range of 5–200 ng/L.
Radiotheragnostics Paradigm for Radioactive Iodine (Iodide) Management of Differentiated Thyroid Cancer
Authors: Slonimsky Einat , Tulchinsky Mark 
Published: June 2020

:
This review of radioactive iodide treatment (RAIT) extends from historical origins to its modern utilization
in differentiated thyroid cancer (DTC). The principles embedded in the radiotheragnostics (RTGs) paradigm
are detailed.

:
The diverse approaches in current practice are addressed, and this broad variability represents a major weakness
that erodes our specialty’s trust-based relationship with patients and referring physicians. The currently developing
inter-specialty collaboration should be hailed as a positive change. It promises to clarify the target-based
terminology for RAIT. It defines RAIT of post total thyroidectomy (PTT), presumably benign thyroid as ‘remnant
ablation’ (RA). ‘Adjuvant treatment’ (AT) referrers to RAIT of suspected microscopic DTC that is inherently
occult on diagnostic imaging. RAIT directed at DTC lesion(s) overtly seen on diagnostic imaging is termed
‘treatment of known disease’ (TKD).

:
It was recently recognized that a ‘recurrent’ DTC is actually occult residual DTC in the majority of cases. Thyroglobulin
with remnant uptake concord (TRUC) method (aka Tulchinsky method) was developed to validate that
a benign remnant in the post-thyroidectomy neck bed, as quantified by the RAI uptake, is concordant with a
measured thyroglobulin (Tg) level at the time of the initial post-thyroidectomy evaluation. It allows recognition of
occult residual DTC contribution to post-thyroidectomy Tg. Case examples demonstrate the application of the
TRUC method for a logical selection of a specific RAIT category, using imaging-guided identification and management
of RAI-avid versus RAI-nonavid residual DTC, i.e. the radiotheragnostics paradigm.
An Insight Into the Anxiolytic Effects of Lignans (Phyllanthin and Hypophyllanthin) and Tannin (Corilagin) Rich Extracts of Phyllanthus amarus : An In-Silico and In-vivo approaches
Authors: Chopade Atul R. , Pol Rahul P. , Patil Pramod A. , Dharanguttikar Vyankatesh R. , Naikwade Nilofar S. , Dias Remeth J. , Mali Suraj N. 
Published: June 2020

:
The extracts and the compounds isolated from Phyllanthus amarus Schumm and Thonn
(Family: Euphorbiaceae) have shown a wide spectrum of pharmacological activities including
antiviral, antibacterial, antiplasmodial, antimalarial, antimicrobial, anticancer, antidiabetic,
hypolipidemic, antioxidant, hepatoprotective, nephroprotective and diurectic properties.

Background:
This investigation was aimed at exploring the anxiolytic potential of Phyllanthus
amarus standardized extracts and predict probable role of marker phyto constitutents.

Objective and Methods:
Three standardized extracts of Phyllanthus amarus plant viz. standardized
aqueous extract of Phyllanthus amarus whole plant (PAAE), standardized methanolic extract of P.
amarus leaf (PAME) and the standardized hydro-methanolic extract of P. amarus leaf (PAHME)
were tested in the classical animal models of anxiety: Elevated plus-maze model and Light & Dark
Exploration test.

Results:
The lower doses of the tannin rich extract (PAHME) of the P. amarus possess significant
anxiolytic activity compared to lignin rich (PAME) and aqueous extracts (PAAE), while at a
higher dose (400mg/kg) the results of all three extracts appears to be potentially sedative. While
the molecular docking studies support these probable anxiolytic, the sedative effects of the
Phyllanthus amarus extracts could be due to the interaction of tannins and lignans with the GABAbenzodiazepine
receptor complex.

Conclusion:
The results of the present study indicate that the tannin-rich extract of the P. amarus
may have potential clinical applications in the management of anxiety. It can be further studied for
optimum dosage to be used as a future of anti-anxiety drug development or as a standardized
Phytomedicine.
Ultrasound-promoted Green Synthesis of pyrido[2,1-a]isoquinoline Derivatives and Studies on their Antioxidant Activity
Authors: Sharafian Shirin , Hossaini Zinatossadat , Rostami-Charati Faramarz , Khalilzadeh Mohammad A. 
Published: June 2020

Aims & Objective:
An efficient procedure for the synthesis of pyrido[2,1-a]isoquinoline
derivatives in excellent yields was investigated using catalyst-free multicomponent reaction of
phthaladehyde, methylamine, activated acetylenic compounds, alkyl bromides and
triphenylphosphine in water under ultrasonic irradiation at room temperature. In addition, Diels-
Alder reactions of pyrido[2,1-a]isoquinoline derivatives with activated acetylenic compounds
under ultrasonic irradiation are investigated in two procedures. The advantages of this procedure
compared to report methods are short time of reaction, high yields of product, easy separation of
product, clean mixture of reaction and green media for performing reaction. In addition, because of
having isoquinoline core in synthesized compounds, in this research antioxidant activity of some
synthesized compounds was studied.

Materials and Methods:
To a stirred mixture of phthalaldehyde 1 (2 mmol) and methylamine 2 (2
mmol) in water (3 mL) under ultrasonic irradiation was added to activated acetylenic compounds 4
after 20 min. Alkyl bromide 3 and triphenylphosphine 5 react in another pot in water (3 mL) under
ultrasonic irradiation for 15 min. After this time, this mixture was added to the first pot. After
completion of the reaction, the solid residue was separated by filtration and washed with Et2O to
afforded pure title compound 6.

Results:
In this work, generation of pyrido[2,1-a]isoquinoline derivatives 6 are performed using
phthalaldehyde 1, methylamine 2, α-halo substituted carbonyls 3, activated acetylenic compounds
4 and triphenylphosphine 5 in water under ultrasonic irradiation condition at room temperature in
excellent yield at short time.

Conclusion:
In summary, multicomponent reaction of phthaladehyde, methylamine, activated
acetylenic compounds, alkyl bromides and triphenylphosphine in water under ultrasonic irradiation
at room temperature produced pyrido[2,1-a]isoquinoline derivatives in excellent yields. Also,
Diels-Alder reaction of pyrido[2,1-a]isoquinoline derivatives with activated acetylenic compounds
and triphenylphosphine under ultrasonic irradiation is investigated in two procedures. Also, the
antioxidant activities of 6a, 6c, 6g and 6i were evaluated by DPPH radical scavenging and ferric
reducing power analyzes. The compounds 6a exhibit excellent DPPH radical scavenging activity
and FRAP compared to synthetic antioxidants BHT and TBHQ. The chief benefits of our method
are high atom economy, green reaction conditions, higher yield, shorter reaction times, and easy
work-up, which agree with some principles of green chemistry.
Chemical Variability and Antioxidant Activities of the Essential Oils of the Aerial Parts of Ammoides verticillata and the Roots of Carthamus caeruleus and their Synergistic Effect in Combination
Authors: Mami Imane Rihab , Merad-Boussalah Noria , El Amine Dib Mohammed , Tabti Boufeldja , Costa Jean , Muselli Alain 
Published: June 2020

Aim and Objective:
Oxidative stress is implicated in the development and progression
of many diseases. Some of the appropriate actions that could taken to resolve the problem of these
diseases are search for new antioxidant substances isolated from plants. The aims of this study
were to research the intraspecies variations of A. verticillata and C. caeruleus essential oils from 8
locations using statistical analysis, the in vitro antioxidant properties of collective essential oils and
in combinations.

Materials and Methods:
The essential oils were analyzed by GC and GC-MS. The intraspecies
variations of the essential oil compositions were discussed using principal component analysis
(PCA) and cluster analysis (CA). The antioxidant properties were evaluated DPPH-radical
scavenging activity and β-carotene bleaching test.

Results:
The main components of Ammoides verticillata collective essential oil (Coll EO) were
thymol (30.5%), carvacrol (23.2%), p-cymene (13.1%), limonene (12.5%) and terpinene-4-ol
(12.3%). While roots of Carthamus caeruleus essential oil were dominated by carline oxide
(86.2%). The chemical variability allowed the discrimination of two main Groups for both Coll
EOs. A direct correlation between the altitudes, climate and the chemical compositions was
evidenced. Ammoides verticulata and Carthamus caeruleus Coll Eos showed good antioxidant
activity. In binary mixture, the interaction between both Coll Eos and between oils rich of thymol
and/or carvacrol with carlina oxide produced the best synergistic effects compared to individual
essential oils and the synthetic antioxidant (BHT).

Conclusion:
Ammoides verticillata and Carthamus caeruleus essential oil blends can be used as a
natural food preservative and alternative to chemical antioxidants.
Dysregulation of the Gut-Brain Axis, Dysbiosis and Influence of Numerous Factors on Gut Microbiota Associated Parkinson’s Disease
Authors: Kaur Gagandeep , Behl Tapan , Bungau Simona , Kumar Arun , Uddin Md. Sahab , Mehta Vineet , Zengin Gokhan , Mathew Bijo , Shah Muhammad Ajmal , Arora Sandeep 
Published: June 2020

Background:
Parkinson’s disease (PD) has been one of the substantial social, medical concern and, burdens of
the present time. PD is a gradually devastating neurodegenerative disorder of the neurological function marked with αsynucleinopathy affecting numerous regions of the brain-gut axis, as well as the central, enteric, and autonomic nervous system. Its etiology is a widely disputed topic.

Objective:
This review emphasizes to find out the correlation among the microbial composition and the observable disturbances in the metabolites of the microbial species and its impact on the immune response, which may have a concrete implication on the occurrence, persistence and, pathophysiology of PD via the gut-brain axis.

Methods:
An in-depth research and the database was developed from the available peer reviewed articles till date (March
2020) utilizing numerous search engines like PubMed, MEDLINE and, other internet sources.

Results:
Progressively increasing shreds of evidence have proved the fact that dysbiosis in the gut microbiome plays a central role in many neurological disorders, such as PD. Indeed, a disordered microbiome-gut-brain axis in PD could be focused
on gastrointestinal afflictions that manifest primarily several years prior to the diagnosis, authenticating a concept wherein
the pathological pathway progresses from the intestine reaching the brain.

Conclusion:
The microbiota greatly affects the bidirectional interaction between the brain and the gut via synchronized neurological, immunological, and neuroendocrine mechanisms. It can be concluded that a multitude of factors discussed in this
review steadily induce the onset of dysbacteriosis that may exacerbate the etiologic mechanism of Parkinson’s disease.
Computational Analysis of Dynamical Fluctuations of Oncoprotein E7 (HPV 16) for the Hot Spot Residue Identification Using Elastic Network Model
Authors: Malik Rabbiah , Fazal Sahar , Kamal Mohammad Amjad 
Published: June 2020

Aims:
To find out Potential Drug targets against HPV E7.

Background:
Oncoprotein E7 of Human Papilloma Virus (HPV-16), after invading human body
alter host protein-protein interaction networks caused by the fluctuations of amino acid residues present
in E7. E7 interacts with Rb protein of human host with variable residual fluctuations, leading
towards the progression of cervical cancer.

Objective:
Our study was focused our computational analysis of the binding and competing interactions
of the E7 protein of HPV with Rb protein.

Methods:
Our study is based on analysis of dynamic fluctuations of E7 in host cell and correlation
analysis of specific residue found in motif of LxCxE, that is the key region in stabilizing interaction
between E7 and Rb.

Results and Discussion:
Cysteine, Leucine and Glutamic acid have been identified as hot spot residues
of E7 which can provide platform for drug designing and understanding of pathogenesis of
cervical cancer, in future. Our study shows validation of the vitality of linear binding motifs LxCxE
of E7 of HPV in interacting with Rb as an important event in propagation of HPV in human cells
and transformation of infection into cervical cancer.

Conclusion:
Our study shows validation of the vitality of linear binding motifs LxCxE of E7 of
HPV in interacting with Rb as an important event in propagation of HPV in human cells and transformation
of infection into cervical cancer.

Other:
E7 interacts with Rb protein of human host with variable residual fluctuations, leading towards
the progression of cervical cancer.
Comprehensive Analysis of Key Proteins Involved in Radioresistance of Prostate Cancer by Integrating Protein-protein Interaction Networks
Authors: Qian Duocheng , Li Quan , Zhu Yansong , Li Dujian 
Published: June 2020

Background:
Radioresistance remains a significant obstacle in the treatment of prostate
cancer (PCa). The mechanisms underlying the radioresistance in PCa remained to be further
investigated.

Methods:
GSE53902 dataset was used in this study to identify radioresistance-related mRNAs.
Protein-protein interaction (PPI) network was constructed based on STRING analysis. DAVID
system was used to predict the potential roles of radioresistance-related mRNAs.

Results:
We screened and re-annotated the GSE53902 dataset to identify radioresistance-related
mRNAs. A total of 445 up-regulated and 1036 down-regulated mRNAs were identified in
radioresistance PCa cells. Three key PPI networks consisting of 81 proteins were further constructed
in PCa. Bioinformatics analysis revealed that these genes were involved in regulating MAP kinase
activity, response to hypoxia, regulation of the apoptotic process, mitotic nuclear division, and
regulation of mRNA stability. Moreover, we observed that radioresistance-related mRNAs, such as
PRC1, RAD54L, PIK3R3, ASB2, FBXO32, LPAR1, RNF14, and UBA7, were dysregulated and
correlated to the survival time in PCa.

Conclusion:
We thought this study would be useful to understand the mechanisms underlying
radioresistance of PCa and identify novel prognostic markers for PCa.