bluuebunny/crossref_metadata_2025_split huggingface dataset:
Graph theory analysis reveals premature ejaculation is a brain disorder with altered structural connectivity and depressive symptom: A DTI‐based connectome study
Authors: Chen Jianhuai , Yang Jie , Xiang Ziliang , Huang Xinfei , Lu Chao , Liu Shaowei , Chen Yun , Hu Jun 
Published: November 2020

AbstractRecent research has shown that premature ejaculation (PE) is associated with negative psychological effects (e.g., depression) and the decline of control over ejaculation is accompanied by structural and functional abnormalities in specific brain areas and connections. However, little is known about the alterations of topological organization in the brain network of patients with PE and its relationship with depressive symptom. We acquired diffusion tensor images, sexual function and depression assessment in 16 lifelong PE patients with depressive symptom, 16 lifelong PE patients without depression and 32 age‐ and education‐matched healthy controls (HC). The differences in nodal centrality and different hub regions among the three groups were compared. Correlation analyses were conducted between the nodal centrality of brain regions displaying significant group differences and the clinical parameters of PE patients. PE patients with depression had increased nodal degree in the right middle frontal gyrus (orbital part) (ORBmid.R) (survived FDR‐correction) compared with HC and PE without depression. PE patients with depression also had increased nodal degree in the left and right posterior cingulate gyrus (PCG.L; PCG.R) compared with HC. In addition, PE with depression had increased nodal betweenness in ORBmid.R compared with HC and PE without depression. Moreover PE with depression had decreased nodal participation in the right rolandic operculum (ROL.R), postcentral gyrus (PoCG.R) and supramarginal gyrus (SMG.R) compared with HC, and had decreased nodal participation in ROL.R and the right inferior parietal gyrus (IPL.R) compared with PE without depression, while PE without depression had increased nodal participation in the left precuneus (PCUN.L) compared with HC. The degree and betweenness of ORBmid.R were positively correlated with the total scores of Beck depression inventory (BDI) while the participation of IPL.R had a negative association with the total scores of BDI. Different hubs were found among PE patients with and without depression and HC based on nodal degree, betweenness and participation; however, no significant group differences were found in the frequency distribution of high‐degree hubs, high‐betweenness hubs, provincial hubs and connector hubs. These findings demonstrated that PE was a brain disorder with altered structural connectivity pattern of brain network and depressive symptom, which suggested that altered structural connectivities of the fronto‐cingulate‐parietal control network were core neurobiological features associated with PE and depression. Together, these alterations could prove helpful for understanding the pathophysiological mechanisms of PE in depression.
Pathophysiological associations of transcallosal dysfunction in ALS
Authors: van den Bos Mehdi A. J. , Higashihara Mana , Geevasinga Nimeshan , Menon Parvathi , Kiernan Matthew C. , Vucic Steve 
Published: November 2020

AbstractAimInvolvement of the corpus callosum has been identified as a feature of amyotrophic lateral sclerosis (ALS), particularly through neuropathological studies. The aim of the present study was to determine whether alteration in transcallosal function contributed to the development of ALS, disease progression and thereby functional disability.MethodsTranscallosal function and motor cortex excitability were assessed in 17 ALS patients with results compared to healthy controls. Transcallosal inhibition (interstimulus intervals (ISI) of 8–40 ms), short interval intracortical facilitation (SICF) and inhibition (SICI) were assessed in both cerebral hemispheres. Patients were staged utilising clinical and neurophysiological staging assessments.ResultsIn ALS, there was prominent reduction of transcallosal inhibition (TI) when recorded from the primary and secondary motor cortices compared to controls (F = 23.255, p < 0.001). This reduction of TI was accompanied by features indicative of cortical hyperexcitability, including reduction of SICI and increase in SICF. There was a significant correlation between the reduction in TI and the rate of disease progression (R = −0.825, p < 0.001) and reduction in muscle strength (R = 0.54, p = 0.031).ConclusionThe present study has established that dysfunction of transcallosal circuits was an important pathophysiological mechanism in ALS, correlating with greater disability and a faster rate of disease progression. Therapies aimed at restoring the function of transcallosal circuits may be considered for therapeutic approaches in ALS.
Zoned quartz phenocrysts in supercooled melt inclusions in granulites from continental collision orogens
Authors: Hiroi Yoshikuni , Hokada Tomokazu , Kayama Masahiro , Miyake Akira , Adachi Tatsuro , Prame Bernard , Perera Keerthi , Satish‐Kumar Madhusoodhan , Osanai Yasuhito , Motoyoshi Yoichi , Ellis David J. , Shiraishi Kazuyuki 
Published: November 2020

AbstractFelsite inclusions (FIs) in granulite garnets from continental collision orogens are supercooled felsic melt inclusions. Not only do these represent non‐equilibrium textures, such as dendritic and spherulitic crystals of quartz and other minerals, but the porphyritic texture is that of hypabyssal and volcanic rocks. This paper presents representative zoned quartz phenocryst‐bearing FIs in various granulites from the Highland Complex in central Sri Lanka, the Lützow‐Holm Complex in East Antarctica, the Grenville Province in southeastern Canada, and the Kerala Khondalite Belt in southern India. Quartz phenocrysts show simple and definite cathodoluminescence (CL) zoning with euhedral bright cores and dark rims and overgrowths. Euhedral quartz never develops in subsolidus metamorphic rocks except for vein quartz, and is characteristic of growth in a melt phase. Groundmass quartz surrounding quartz phenocrysts within the FIs is always dark in CL, whereas matrix quartz outside garnet and single‐grain inclusion quartz in garnet are usually brighter than the cores of quartz phenocrysts. The close relationship between violet CL emission intensity and Ti content of quartz indicates different growth temperatures in harmony with the inferred crystallization sequence. The preservation of CL growth zoning in quartz phenocrysts and fine non‐equilibrium textures imply that the cooling rates of some granulites are 1 to 2 orders of magnitude faster than so far presumed.
Are diabetes and dental care providers in the Republic of Mauritius advising patients about the importance of oral health in diabetes management?
Authors: Paurobally Nesha , Kruger Estie , Tennant Marc 
Published: November 2020

ABSTRACTDiabetes and dental care providers may greatly contribute in the early detection of oral diseases and diabetes, respectively, and in the prevention of complications of diabetes. However, there is limited collaboration and referrals between these two groups of health professionals.ObjectiveTo investigate whether diabetic providers are addressing the importance of oral care in the management of diabetes and whether dental care providers are advising their patients with diabetes about the importance of glycaemic control.MethodDescriptive statistics was used to report data collected from 720 patients with diabetes using a closed‐end questionnaire. Logistic regression analysis revealed the factors significantly impacting whether participants received advice from healthcare providers.ResultsThe majority of participants did not receive advice from either diabetes (84%) or dental (75%) care providers regarding the reciprocal nature of diabetes and periodontitis. The factors significantly affecting receiving advice from diabetes care providers were place of residence (p = 0.003), self‐reported type of diabetes (p = 0.000) receiving advice from dental care providers (p = 0.000); from dental care providers – education (p = 0.020), place of residence (p = 0.004), the number of years since diagnosis of diabetes (p = 0.002), frequency of dental visits (p = 0.000) and receiving advice from diabetes care providers (p = 0.000).ConclusionDiabetes and dental care providers in Mauritius are not addressing oral health care as an essential component of diabetes care. Patients with diabetes are neither being advised about the importance of regular dental visits by their treating doctor, nor about the importance of glycaemic control in the prevention of oral complications by their dentist.
Holiday advertising versus gift cards: Influence of religiosity on retailer evaluations
Authors: Taylor Valerie A. , Minton Elizabeth A. 
Published: November 2020

AbstractThis research examines how consumers’ religiosity influences response to marketing communication mediums that are viewed either actively (e.g., holiday gift cards that are actively sought out) versus passively (e.g., holiday ads that a consumer is passively exposed to). Using an experimental method, this research first shows that consumer religiosity positively influences retailer evaluations. Next, this research examines how an actively viewed marketing communication (using the context of holiday gift cards) versus a passively viewed marketing communication (using the context of holiday ads) influences consumers’ evaluations of retailers and the explanatory mechanisms underlying those evaluations. Results show that consumers with higher extrinsic religiosity have higher pride in response to gift cards as opposed to ads, which leads to higher retailer evaluations. In contrast, consumers with higher intrinsic religiosity have lower guilt in response to gift cards as opposed to ads, which also leads to higher retailer evaluations. These findings are discussed in relation to the literature on pride and guilt and build off belief congruence theory. Additionally, implications for marketers and retailers are identified.
Performance evaluation of platelet counting of Abbott Alinity hq and Sysmex XN‐9000 automated hematology analyzer compared with international reference method
Authors: Kim Hyun‐Young , Bang Sung‐Hwan , Cho Duck , Kim Hee‐Jin , Kim Sun‐Hee 
Published: November 2020

AbstractIntroductionAccurate platelet counting is essential for risk assessment of bleeding and thrombosis. Abbott Alinity hq hematology analyzer was recently introduced, and its performance in platelet counting has yet to be evaluated comprehensively. In this study, we evaluated the performance of the optical platelet counting of Abbott Alinity hq (Alinity‐PLT) and the impedance and fluorescent platelet counting of Sysmex XN‐9000 (XN‐PLT‐I and XN‐PLT‐F) compared with the international reference method.MethodsBlood samples were analyzed via Alinity hq and XN‐9000 with PLT‐F channel. Immuno‐platelet (ImmnoPLT) reference method was performed with CD41/CD61 antibodies using FACSLyricTM flow cytometer (BD). Precision was determined using 10 replicates in a single run, and the platelet counts of Alinity‐PLT, XN‐PLT‐I, XN‐PLT‐F, and ImmnoPLT were compared.ResultsAt a platelet count of 13 × 109/L, the CVs of Alinity‐PLT, XN‐PLT‐I, and XN‐PLT‐F were 4.2%, 6.7%, and 4.3%, respectively, and at a platelet count of 44 × 109/L, all showed a CV of less than 3%. For the total 210 samples, all three methods showed a very strong correlation with ImmunoPLT (r > 0.99). For platelet levels below 20 × 109/L, XN‐PLT‐F showed the strongest correlation with ImmunoPLT (r = 0.975), and for platelet levels of 20‐100 × 109/L, Alinity‐PLT and XN‐PLT‐I were comparable to ImmunoPLT. For platelet levels of 100‐450 × 109/L, XN‐PLT‐I was the most comparable to ImmunoPLT, and for platelet levels above 450 × 109/L, Alinity‐PLT was comparable to ImmunoPLT.ConclusionsAll three methods were highly correlated with ImmunoPLT, and each method had different performance advantages according to the platelet levels.
CircSAMD4A aggravates H/R‐induced cardiomyocyte apoptosis and inflammatory response by sponging miR‐138‐5p
Authors: Hu Xiaorong , Ma Ruisong , Cao Jianlei , Du Xianjin , Cai Xinyong , Fan Yongzhen 
Published: November 2020

AbstractHypoxia/reoxygenation (H/R)‐induced myocardial cell injury is the main cause of acute myocardial infarction (AMI). Many proofs show that circular RNA plays an important role in the development of AMI. The purpose of this study was to investigate the role of circSAMD4A in H/R‐induced myocardial injury. The levels of circular SAMD4A (circSAMD4A) were detected in the heart tissues of AMI mice and H/R‐induced H9C2 cells, and the circSAMD4A was suppressed in AMI mice and H/R‐induced H9C2 cells to investigate its’ function in AMI. The levels of circSAMD4A and miR‐138‐5p were detected by real‐time quantitative PCR, and MTT assay was used to detect cell viability. TUNEL analysis and Annexin V‐FITC were used to determine apoptosis. The expression of Bcl‐2 and Bax proteins was detected by Western blot. IL‐1β, TNF‐α and IL‐6 were detected by ELISA kits. The study found that the levels of circSAMD4A were up‐regulated after H/R induction and inhibition of circSAMD4A expression would reduce the H/R‐induced apoptosis and inflammation. MiR‐138‐5p was down‐regulated in H/R‐induced H9C2 cells. circSAMD4A was a targeted regulator of miR‐138‐5p. CircSAMD4A inhibited the expression of miR‐138‐5p to promote H/R‐induced myocardial cell injury in vitro and vivo. In conclusion, CircSAMD4A can sponge miR‐138‐5p to promote H/R‐induced apoptosis and inflammatory response.
Combination therapy with anti‐T‐cell immunoglobulin and mucin‐domain containing molecule 3 and radiation improves antitumor efficacy in murine hepatocellular carcinoma
Authors: Kim Kyoung‐Jin , Lee Hye Won , Seong Jinsil 
Published: November 2020

AbstractBackground and AimT‐cell immunoglobulin and mucin‐domain containing molecule 3 (TIM3) has emerged as a promising immune checkpoint inhibitor target; however, immune checkpoint inhibitor monotherapy does not benefit a substantial percentage of patients. Therefore, this study investigated the antitumor effect of anti‐TIM3 therapy combined with radiation in a murine hepatocellular carcinoma (HCC) model.MethodsThe effect of radiation on TIM3 expression was determined in murine and human HCC cells using western blotting, immunohistochemistry, and flow cytometry. Tumor growth and survival rate were measured to evaluate the antitumor effect of this combination therapy. Tumor immunological parameters were assessed using flow cytometry and histology.ResultsTIM3 was upregulated in tumor‐infiltrating CD8+ and CD4+ T cells in radiation‐treated HCa‐1‐implanted mice. Combination treatment significantly delayed tumor growth compared with monotherapy (P < 0.01). Overall survival was improved in the combination group compared with that in the anti‐TIM3 or radiation monotherapy groups (median survival time: 52 days vs 26 or 38 days, respectively, P < 0.001). The antitumor effect of the combination treatment was associated with increased apoptosis and decreased proliferation of tumor cells and reinvigorated CD8+ T‐cell activation. CD8+ T‐cell depletion reversed the antitumor efficacy of the combination treatment. These findings suggest that CD8+ T cells play key roles in the therapeutic effect of the combination treatment.ConclusionAnti‐TIM3 and radiation combination therapy significantly improved the antitumor effect in a murine HCC model, as evidenced by inhibited tumor growth and increased overall survival. This approach could be a novel combined immune‐radiotherapy strategy for HCC.
Efficacy and safety of sofosbuvir/velpatasvir in a real‐world chronic hepatitis C genotype 3 cohort
Authors: Wong Yu Jun , Thurairajah Prem Harichander , Kumar Rahul , Tan Jessica , Fock Kwong Ming , Law Ngai Moh , Li Weiquan , Kwek Andrew , Tan Yu Bin , Koh Jingyun , Lee Zheng Cong , Kumar Loshini Senthil , Teo Eng Kiong , Ang Tiing‐Leong 
Published: November 2020

AbstractBackground and AimReal‐world data on sofosbuvir/velpatasvir with and without ribavirin (SOF/VEL ± RBV), particularly among patients with genotype 3 (GT3) decompensated cirrhosis, prior treatment, coinfection, and hepatocellular carcinoma (HCC), are scarce. We aimed to assess the efficacy and safety of SOF/VEL ± RBV in a real‐world setting that included both community and incarcerated GT3 hepatitis C virus (HCV) patients.MethodsWe included all GT3 HCV patients treated with SOF/VEL ± RBV in our institution. The primary outcome measure was the overall sustained virological response 12 weeks after treatment (SVR12), reported in both intention‐to‐treat (ITT) and per‐protocol analyses. The secondary outcome measures were SVR12 stratified by the presence of decompensated cirrhosis, prior treatment, HCC, and HIV/hepatitis C virus coinfection and the occurrence rate of serious adverse events requiring treatment cessation or hospitalization.ResultsA total of 779 HCV patients were treated with 12 weeks of SOF/VEL ± RBV, of which 85% were treated during incarceration. Among the 530 GT3 HCV patients, 31% had liver cirrhosis, and 6% were treatment‐experienced. The overall SVR12 for GT3 was 98.7% (95% confidence interval: 97.3%, 99.5%) and 99.2% (95% confidence interval: 98.1%, 99.8%) in ITT and per‐protocol analyses, respectively. High SVR12 was also seen in ITT analysis among GT3 HCV patients with decompensated cirrhosis (88%), prior treatment (100%), HCC (100%), and HIV/hepatitis B virus coinfection (100%). Apart from one patient who developed myositis, no other serious adverse events were observed.ConclusionThe SOF/VEL ± RBV is a safe and efficacious treatment option for GT3 HCV patients in a real‐world setting. SOF/VEL with RBV may be considered for decompensated GT3 HCV patients.
A review of non‐alcoholic fatty liver disease in non‐obese and lean individuals
Authors: Ahadi Mitra , Molooghi Kasra , Masoudifar Negin , Namdar Ali Beheshti , Vossoughinia Hassan , Farzanehfar Mohammadreza 
Published: November 2020

AbstractNon‐alcoholic fatty liver disease (NAFLD) is one of the most common causes of hepatic disorders. It represents a wide range of chronic liver diseases in patients with no history of significant alcohol consumption, starting with simple steatosis and progressing towards non‐alcoholic steatohepatitis, cirrhosis, and ultimately hepatocellular carcinoma. NAFLD is usually associated with type 2 diabetes mellitus, dyslipidemia, metabolic syndrome, and obesity. This disease has mostly been studied in obese individuals; however, it has been widely reported and studied among the lean/non‐obese population in recent years. The pathogenesis of NAFLD in non‐obese patients is associated with various genetic predispositions, particularly a patatin‐like phospholipase domain‐containing protein 3 G allele polymorphism, which results in the accumulation of triglyceride in the liver and resistance to insulin. Additionally, dietary factors such as high fructose consumption seem to play a substantial role in the pathology of non‐obese NAFLD. Although there is not enough evidence on the treatment of NAFLD in non‐obese patients, the standard approach is to advise altering one's lifestyle in order to diminish visceral adiposity. Dietary modification, weight loss, and increased physical activity are highly recommended. We aimed to review and summarize the existing information on the prevalence, pathogenesis, genetic predispositions, diagnosis, and treatment of NAFLD in non‐obese patients according to the latest literature.
Opioid Prescribing in the 2016 Medicare Fee‐for‐Service Population
Authors: Maciejewski Matthew L. , Zepel Lindsay , Hale Sarah L. , Wang Virginia , Diamantidis Clarissa J. , Blaz Jacquelyn W. , Olin Serene , Wilson‐Frederick Shondelle M. , James Cara V. , Smith Valerie A. 
Published: November 2020

BACKGROUND AND OBJECTIVESOpioid use and misuse are prevalent and remain a national crisis. This study identified beneficiary characteristics associated with filling opioid prescriptions, variation in opioid dosing, and opioid use with average daily doses (ADDs) equal to 120 morphine milligram equivalents (MMEs) or more in the 100% Medicare fee‐for‐service (FFS) population.DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTSIn a cohort of FFS beneficiaries with 12 months of Medicare Part D coverage in 2016, we examined patient factors associated with filling an opioid prescription (n = 20,880,490) and variation in ADDs (n = 7,325,031) in a two‐part model. Among those filling opioids, we also examined the probability of ADD equal to 120 MMEs or more via logistic regression.RESULTSAbout 35% of FFS beneficiaries had one or more opioid prescription fills in 2016 and 1.5% had ADDs equal to 120 MMEs or more. Disability‐eligible beneficiaries and beneficiaries with multiple chronic conditions were more likely to fill opioids, to have higher ADDs or were more likely to have ADD equal to 120 MMEs or more. Beneficiaries with chronic obstructive pulmonary disease (COPD) were more likely to fill opioids (odds ratio (OR) = 1.47, 95% confidence interval (CI) = 1.46–1.47), have higher ADDs (rate ratio = 1.06, 95% CI = 1.06–1.06) when filled and were more likely to have ADD equal to 120 MMEs or more (OR = 1.23, 95% CI = 1.21–1.24). Finally, black and Hispanic beneficiaries were less likely to fill opioids, had lower overall doses and were less likely to have ADDs equal to 120 MMEs or more compared to white beneficiaries.CONCLUSIONSeveral beneficiary subgroups have underappreciated risk of adverse events associated with ADD equal to 120 MMEs or more that may benefit from opioid optimization interventions that balance pain management and adverse event risk, especially beneficiaries with COPD who are at risk for respiratory depression.
Systematic Review of Randomized Controlled Trials in Australian Nursing Homes from 2000 to 2018
Authors: Pham Tony , Bugeja Lyndal , Holmes Alice , Ibrahim Joseph E. 
Published: November 2020

BACKGROUND/OBJECTIVESHigh‐quality research provides an evidence base for optimal practice care in clinical settings, yet, little is known about the nature and extent of randomized control trials (RCTs) conducted in Australian nursing homes (NHs). Research from other settings and other countries is not necessarily transferable to the Australian NH sector. We sought to identify and describe RCTs conducted in Australia which investigated interventions targeted at improving care for NH residents.DESIGNThe design of this study comprised a systematic literature search with a narrative review. Studies were included if they were RCTs published after 2000, conducted in an Australian NH, and evaluated a health intervention which may have directly or indirectly benefitted the NH resident.SETTINGAustralian NHs.PARTICIPANTSNursing home residents.MEASUREMENTSJurisdiction (state or territory where the study was conducted), number of NHs recruited in each trial, number of residents included in each trial, intervention characteristics, comparator characteristics, and characteristics of outcome.RESULTSOnly 43 articles reporting on 39 RCTs were identified. In contrast, 30 Australian musculoskeletal RCTs were published in just 2 years (2011–2012). Most of the RCTs identified were conducted in New South Wales (n = 14), Queensland (n = 10), and Victoria (n = 9). The mean number of NHs included in each trial was 22.4 (standard deviation (SD) = 27.0), with a median of 14.5 (interquartile range (IQR) = 27.8), while the mean number of residents included was 412.4 (SD = 921) with a median of 187 (IQR = 341.0). The most common interventions targeted: managing dementia (n = 20), prevention of falls (n = 7), and addressing mental health issues (n = 6).CONCLUSIONThis review provides evidence of the paucity of high‐quality research in the form of RCTs, in the Australian NH setting and demonstrates the need for Australia to improve its research capability in the NH sector.