bluuebunny/crossref_metadata_2025_split huggingface dataset:
Granulocyte Colony Stimulating Factor Enhances Decidualization Process of Endometrial Stromal Cells Through STAT3/HOXA10 Axis
Authors: Zhang Huakun , Wu Zhengzhong , Yang Ningjie , Wu Shuhua , Fan Jing , Wang Ping , Li Xuemei 
Published: December 2024

AbstractBackground: Recurrent implantation failure (RIF) is characterized by the repeated failure of implantation, often linked to impaired endometrial receptivity. This study investigates how granulocyte colony‐stimulating factor (G‐CSF) promotes endometrial stromal cell decidualization. Methods: THESCs (human telomerase reverse transcriptase‐immortalized endometrial stromal cells) were used as an in vitro cell model to induce decidualization. The effects of G‐CSF on the expression of decidualization genes and apoptosis during decidualization were examined. Additionally, a chemical inhibitor of signal transducer and activator of transcription 3 (STAT3) and the small interfering RNA (siRNA) targeting Homeobox A10 (Hoxa10) were employed to explore the involvement of the STAT3/HOXA10 axis in the action of G‐CSF. Results: G‐CSF promoted decidualization markers expression and suppressed apoptosis in THESCs Treatment with G‐CSF enhanced STAT3 activation during decidualization induction. STAT3 inhibition diminished the effects of G‐CSF on decidualization marker expression and apoptosis suppression. Furthermore, it was demonstrated that G‐CSF increased Hoxa10 expression in a STAT3‐dependent manner. Silencing Hoxa10 abrogated the effects of G‐CSF on promoting decidualization. Conclusion: G‐CSF enhances decidualization of endometrial stromal cells via STAT3/HOXA10 axis activation. These findings suggest that optimal G‐CSF delivery strategies could improve endometrial receptivity in RIF patients.
Critical Challenges of Intravenous Nanomaterials Crossing the Blood‐Brain Barrier: from Blood to Brain
Authors: Luo Weikang , Chen Cong , Guo Xin , Guo Xiaohang , Zheng Jun , Liu Jingjing , Fan Xudong , Luo Ming , Yu Zhe , Li Haigang , Liu Juewen , Wang Yang 
Published: December 2024

AbstractDespite recent advancements in the development of blood‐brain barrier (BBB)‐crossing nanomaterials for intravenous administration, there have been very few successful cases in clinical trials. Ongoing challenges within the body impede the precise therapeutic effects of these nanomaterials from reaching their intended target area. Therefore, a comprehensive analysis of the entire pathway that BBB‐crossing nanomaterials must traverse‐from the bloodstream to the brain‐along with an understanding of the obstacles encountered along the way, is essential for advancing these materials to clinical trials. This review begins with a brief overview of the structure and function of the BBB, as well as the pathways and strategies for crossing it. Next, it is discussed and analyzed the common challenges that BBB‐crossing nanomaterials in reaching their target sites in the brain from the bloodstream. To address these challenges, an “eight‐step” guideline strategy is proposed. By leveraging the principles of precision medicine, the design and customization of cascade‐targeted BBB‐crossing nanomaterials that can overcome multiple obstacles show promise for future clinical trials and practical applications. Finally, a perspective on the future direction of this field is offered.
Rutile‐Structured (RuSnSbReF)Ox High Entropy Solid Solution for Acidic Oxygen Evolution Reaction
Authors: Huang Quanbo , Ye Zhiguo , Peng Xinyuan , Ao Peiyun , Lv Hongwei , Huang Juntong , Li Duosheng 
Published: December 2024

AbstractDeveloping efficient and low‐cost electrocatalysts with exceptional durability and electrocatalytic activity for the acidic oxygen evolution reaction (OER) presents a significant challenge, primarily owing to the irreversible dissolution of the electrocatalysts in acidic electrolytes. Here, a rutile‐structured (RuSnSbReF)Ox high entropy solid solution is successfully fabricated on the substrate of corrosion‐resistant titanium via a high‐temperature sintering technique. The (RuSnSbReF)Ox electrocatalyst for the OER achieves a super‐low overpotential of 156 mV and a small Tafel slope of 23.87 mV dec−1 at a current density of 10 mA cm−2 in a 0.5 M H2SO4 solution. A high‐stable operation potential is performed for the long‐term measurement of 213 h at a current density of 100 mA cm−2. There is a lower energy barrier of the rate‐determining step (RDS) on the Ruthenium (Ru)‐Rhenium (Re) bridge site of the (RuSnSbReF)Ox electrocatalyst in comparison with that of other sites for acidic OER. The reservoir‐like Re species in the (RuSnSbReF)Ox can bestow/save the electrons to the Ru site through O‐bridges, favorably adjusting the electronic structure and the oxidation state. This investigation opens a feasible avenue to develop an efficient and durable Ru‐based electrocatalysts of rutile‐structured high entropy solid solution for the OER toward the practical applications of electrochemical industry in acidic media.
Chemical‐Strain‐Engineered Adaptive Interfaces in Nanocomposite Films for Robust Ferroelectricity
Authors: Ding Jiaqi , Tu Jie , Li Hangren , Xi Guoqiang , Zheng Dongxing , Wang Qingxiao , Zhang Xixiang , Hu Yuanyuan , Zhang Linxing 
Published: December 2024

AbstractStrain is an effective means of tuning the crystal structure to obtain a variety of fascinating properties, but how to apply flexible strain to meet the different needs of the film at each location has rarely been reported. In this study, a novel approach for designing strain‐damping structures that facilitate the imposition of flexible strain is introduced. A wide range of strain modulation is demonstrated in SmCoO3 films (a‐axis:+4.5%–+1.7%, b‐axis: +3.2%–+0.4%, c‐axis:+2.2%–+1.4%) under positive pressure by introducing Sm2O3 as a dopant. When SmCoO3 films are subjected to triaxial tensile strain, they exhibit a ferroelectric polarization of 7.12 µC cm−2. Through positive pressure modulation, resulting in a further increase in the ferroelectric polarization (up to 11.62 µC cm−2, which represents the maximum performance of the orthogonal rare earth transition metal oxide family). Moreover, the electron spin order can be effectively controlled, and the film's saturation magnetization increases to 14.83 emu cm−3 (+94.1%). This damping structure allows for flexible modulation of chemical strain in epitaxial film, achieving a delicate balance between film strain and structure, which provides valuable insights for all ferroelectrics based on structural distortion.
Directed Electron Modulation Stabilizes Iridium Oxide Clusters for High‐Current‐Density Oxygen Evolution
Authors: He Xian , Tan Jiaqi , Deng Bohan , Zhao Wei , Zhang Zhuting , Zheng Zhichuan , Wu Yufeng , Yang Chong , Li Xibo , Lei Ming , Liu Hongyi , Huang Kai , Wu Hui 
Published: December 2024

AbstractThe rapid advancement of the green hydrogen industry has driven a surge in demand for devices that operate over a broad range of current density. Despite this, the development of stable iridium‐based catalysts for high‐current‐density applications in oxygen evolution reactions remains a significant challenge. In this study, directed electron modulation (DEM) of iridium oxide clusters on cobalt hydroxide nanosheets is achieved using a cyclic Joule heating strategy in pure water. The strategy achieves a rapid change of environmental energy during electronic modulation through Joule heating, which ensures strong electronic coupling between IrO2 and Co(OH)2 without significant changes in initial catalyst nanostructure and cluster size. Directed electron modulation optimizes the reactant adsorption ability of the active center (IrO2 cluster) and corresponding reaction kinetics are improved, resulting in the catalyst (DEM‐IrO2@Co(OH)2‐NF) showing excellent performance. The DEM‐IrO2@Co(OH)2‐NF exhibits excellent catalytic activity in alkaline electrolytes with only 296 mV overpotential up to 1 A cm−2 and no significant degradation in 1000 h stability test at 1 A cm−2. Additionally, the anion exchange membrane electrolyzer using DEM‐IrO2@Co(OH)2‐NF||Pt/C requires only 1.68 V at 1 A cm−2 and remains stable for 200 h. This work will provide new directions for optimization of active centers.
Metaplasticity and Reservoir Computing in Bio‐Realistic Artificial Synapses with Embedded Localized Au‐Nanoparticle‐Based Memristors
Authors: Mahata Chandreswar , Kim Gimun , So Hyojin , Ismail Muhammad , Hsu Chih‐Chieh , Kim Sungjoon , Kim Sungjun 
Published: December 2024

AbstractThis research reports on the control of short‐term and long‐term memory in transition metal oxides embedded with localized gold nanoparticles (Au‐NPs). The HfTiOx/TiSiOx switching layer, after the orderly and uniform insertion of Au‐NPs, demonstrates uniform cycle‐to‐cycle DC switching with an ON–OFF ratio >10. Stable low‐resistance states (LRS) and high‐resistance state (HRS) are maintained up to 104 s with multilevel memory characteristics due to the control of oxygen vacancy concentrations. The localized Au‐NPs enhance the local electric field near the HfTiOx/Au‐NP interface, forming controlled conductive filaments, while the high concentration of oxygen vacancies creates a permanent conduction path inside TiSiOx after the electroforming process. The ITO/HfTiOx/Au‐NP/TiSiOx/TaN memristor exhibits stable, controllable gradual bipolar switching and mimics several biological memory functions, including pulse‐width‐dependent plasticity, spike‐timing‐dependent plasticity, pulse‐frequency‐dependent plasticity, and experience‐dependent plasticity. Additionally, a performance of 50k SET/RESET cycles without any significant degradation is achieved and the facilitation of long‐term potentiation/depression are demonstrated. With the help of controlled oxygen vacancy generation on the surface of Au‐NP inside the HfTiOx/TiSiOx switching layer, the memristor can emulate metaplasticity. Evaluation of a reservoir computing system utilizing the volatile switching of the memristor shows efficient processing of temporal data information which is essential for neuromorphic systems.
Efficient and Selective Lithium Extraction from Brine Water Via a Photothermal Sandwich Sieve Structure
Authors: Zhong Hong , Zhao Qinghua , Lai Zhongyu , Xu Dan , Ji Yaxiong , Wang Shifeng , Qin Qi 
Published: December 2024

AbstractLithium is being recognized as a strategic resource on a global scale, mainly because of its growing importance in the production of lithium‐ion batteries for electric vehicles and energy storage systems. Due to its uneven geographical distribution and limited availability on Earth, extracting lithium from brines and seawater presents a sustainable supply pathway. However, conventional lithium extraction techniques are still challenging, necessitating significant costs and energy consumption. This study primarily employs a solar‐utilizing selective extraction strategy for efficient lithium harvesting by designing a solar‐thermal sandwich sieve structure. Herein, a portable solar‐driven lithium extraction device has been developed based on HKUST‐1 and LIG. Due to the sub‐nano channels provided by HKUST‐1, the hydrated Li+ can selectively pass through the MOF layer. The excellent solar heating of the layer enables the device an accelerate vapor escaping, it then facilitates the delivery of Li+, resulting in lithium accumulation at the interface for convenient collection. The maximum lithium extraction capacity in one cycle is 1467 mg m−2, demonstrating good Li+ selectivity absorption with a high Mg2+/Li+ ratio under 1 solar illumination. Moreover, the device shows excellent cycle stability. This work offers an integrated solar utilization for scalable and sustainable lithium extraction from brine water.
Recent Advances in Single‐Atom Catalyst for Solar Energy Conversion: A Comprehensive Review and Future Outlook
Authors: Mehmood Saad , Sk Saddam , Abraham B. Moses , Ahmadipour Mohsen , Pal Ujjwal , Dutta Joydeep 
Published: December 2024

AbstractSingle‐atom catalysts (SACs) are becoming increasingly recognized as highly promising catalytic materials, distinguished by their exceptional atomic efficiency, superior selectivity, and elevated activity levels. This review offers a detailed and comprehensive overview of the recent advancements in SACs, focusing on synthesis strategies, photocatalytic energy conversion applications, and advanced characterization techniques. Various synthetic approaches for fabricating atomically dispersed catalysts are elaborated concisely, emphasizing the importance of achieving precise atomic regulation on compatible supports to ensure strong metal–support interactions. Furthermore, the advanced characterization techniques by analytical tools are illustrated for a deep exploration of catalytic activity and mechanistic insights into uniformly dispersed SACs. Specifically, different kinds of support materials such as metal–organic frameworks (MOFs), their subset zeolitic imidazolate frameworks, and graphitic carbon nitride (g‐C3N4) with diverse coordination and electronic environments are examined. Further, advances in computational techniques and machine learning are transforming SACs development by improving predictive accuracy and reducing trial‐and‐error methods, thereby accelerating the discovery of stable and active catalysts. Finally, current challenges and prospects of SACs based on MOFs, and g‐C3N4 are addressed, providing valuable insights for the continued development and application of these catalysts in various industrial processes and environmental remediation efforts.
Dual Fluorometric and Colorimetric Chemosensor Based on Poly(Arylene Ether Nitrile)s Functionalized Zn(II)Porphyrins for Selective Detection of Cyanide
Authors: Sivakumar Gomathi , Babu Anashwara , Ghanti Bholanath , Swathi J. , R Silambarasan , Nutalapati Venkatramaiah , Banerjee Susanta , Maji Samarendra 
Published: December 2024

AbstractPoly(arylene ether nitrile)s (PAENs) appended with Zn(II)‐porphyrin in varied molar percentages (5% and 10%) are developed as dual colorimetric and fluorometric sensors for highly sensitive and selective cyanide (CN−) detection. The materials, DP‐5%PAEN@Zn and DP‐10%PAEN@Zn, exhibit significant Soret band shifts at 420 ± 2 nm, accompanied by the appearance of a new absorption band at 436 ± 2 nm, indicating strong CN− binding with high association constants of 1.3 × 10⁴ M−¹ and 2.3 × 10⁴ M−¹, respectively. A prominent color change from purple to green allowed for naked eye detection. Spectrofluorimetric studies revealed turn‐off fluorescence with Stern‐Volmer constants (Ksv) of 99.85 × 103 M−¹ for DP‐5%PAEN@Zn and 121.08 × 103 M−¹ for DP‐10%PAEN@Zn, achieving limit of detection (LOD) of 0.177 and 0.099 ppb, respectively. DP‐10%PAEN@Zn demonstrated excellent sensitivity and selectivity toward CN−, and also reusability, as it remained functional after ten TFA treatment cycles. The mechanistic investigation, supported by photophysical, electrochemical, and DFT analyses, revealed a photoinduced electron transfer process via static quenching. Material stability is confirmed through photodegradability, prolonged time, temperature, and humidity testing. Prototype test kits are developed for real‐time visual CN− detection in remote and environmental samples (tap, lake, sewage, and soil). Additionally, a smartphone‐based color recognition assay is implemented for qualitative and quantitative analysis.
PSMA‐Targeting Imprinted Nanogels for Prostate Tumor Localization and Imaging
Authors: Zhang Tong , Berghaus Melanie , Li Yuan , Song Qingmei , Stollenwerk Maria M. , Persson Jenny , Shea Kenneth J. , Sellergren Börje , Lv Yongqin 
Published: December 2024

AbstractProstate‐specific membrane antigen (PSMA) is overexpressed in prostate cancer cells and tumor vasculature, making it an important biomarker. However, conventional PSMA‐targeting agents like antibodies and small molecules have limitations. Antibodies exhibit instability and complex production, while small molecules show lower specificity and higher toxicity. Herein, this work develops a novel PSMA‐targeting synthetic antibody to address prior limitations. This work synthesizes fluorescently labelled, N‐isopropylacrylamide‐based epitope imprinted nanogels (MIP‐M) using a dispersion of magnetic nanoparticles as template carriers with a linear epitope from PSMA's extracellular apical domain as the template. MIP‐M demonstrates high binding affinities for both the epitope template (apparent KD = 6 × 10−10 м) and PSMA (apparent KD = 2.5 × 10−9 м). Compared to reference peptides and human serum albumin, MIP‐M indicates high specificity. Flow cytometry and confocal laser scanning microscopy comparing cell lines displaying normal (PC3) and enhanced (LNCaP) PSMA expression levels, revealed that MIP‐M and a PSMA antibody exhibits comparable binding preferences for the latter cell line. Moreover, MIP‐M demonstrates selectivity on par with the PSMA antibody for targeting PSMA‐positive prostate tumor over normal tissue, enabling discrimination. This MIP‐M addresses stability, production, specificity and toxicity limitations of prior targeting agents and offer a promising alternative for PSMA‐directed cancer diagnosis and treatment.
Engineering Mild‐Photothermal Responsive and NO Donor Prussian Blue Nanozymes Using Mild Synthesis for Inflammation Regulation and Bacterial Eradication in Periodontal Disease
Authors: Li Zheng , Fan Xiaowan , Liu Ying , Yue Muxin , Wu Tingting , Wang Xing , Jiang Wei , Fan Kelong 
Published: December 2024

AbstractPeriodontitis, an infectious disease of periodontal tissues caused by oral bacterial biofilms, is characterized by reactive oxygen species (ROS) accumulation and immune microenvironment imbalance. Multifunctional nanozymes, leveraging their physiochemical properties and enzymatic activities, offer promising antibacterial and anti‐inflammatory strategies for managing periodontitis. In particular, Prussian blue nanozymes (PBzymes) exhibit exceptional ROS control due to their robust catalytic activity, diverse antioxidant functions, and high biocompatibility. However, the practical application of traditional high‐temperature synthesis methods is limited. This study introduces a class of metal‐engineered PBzymes synthesized at room temperature, identified for their potent antioxidative activity and excellent photothermal performance at mild temperatures. Nitric oxide (NO) gas therapy offers promising strategies for targeting deep infections in periodontal tissues. Thus, sodium nitroprusside is introduced into PBzyme to create SPBzyme via an in situ loading method. NO release by SPBzyme enhances antibacterial effects and overcomes resistance linked to bacterial biofilms, resulting in mild‐photothermal antibacterial properties and synergistic antioxidant effects. In vitro antibacterial assays demonstrate the superior efficacy of SPBzyme under mild temperature conditions and near‐infrared light exposure. Furthermore, SPBzyme effectively reduces inflammation and has positive therapeutic effects in periodontal animal models. Overall, mild‐temperature photothermal NO release nanozyme therapy represents a novel approach for treating periodontitis.
Introducing La into a Customized Dual Cu Covalent Organic Framework to Steer CO2 Electroreduction Selectivity from C2H4 to CH4
Authors: Dong Xiao‐Yu , Chen Hong , Wang Shan , Zou Ru‐Yi , Zang Shuang‐Quan , Cai Jinmeng 
Published: December 2024

AbstractCustomizing multi‐metal site catalysts for achieving controllable CO2 reduction reaction (CO2RR) product tuning holds immense promise yet poses formidable challenges. The traditional synthesis method of multi‐metal sites is the pyrolysis of metal‐containing precursors, which is inherently uncontrollable. Herein, a bottom‐up strategy is employed to customize and synthesize multi‐metal sites in covalent organic frameworks (COFs), aiming to controllably switch the CO2 reduction selectivity by regulating the electronic structure of active sites. Briefly, La element provides chances for manipulating and finetuning the electronic structure of the customized dual Cu sites, and converts the main catalytic product of CO2RR from ethylene to methane. Density functional theory calculations show that the introduction of La alters the electronic structure around Cu, enhances CO2 and H2O activation, and changes the formation of energy barriers of key intermediates. To the best of the author's knowledge, this study constructed the first example of customized multi‐metal site COF catalysts and provided new ideas for controllable modulation of products.
Point‐of‐Care Health Diagnostics and Food Quality Monitoring by Molecularly Imprinted Polymers‐Based Histamine Sensors
Authors: Ahmed Shahzad , Ansari Arshiya , Li Zhixuan , Mazumdar Hirak , Siddiqui Moin Ali , Khan Afzal , Ranjan Pranay , Kaushik Ajeet , Vinu Ajayan , Kumar Prashant 
Published: December 2024

AbstractHistamine, a biogenic amine (BA), plays a significant role in various pathophysiological processes and is present in food supplies, serving as an indicator of freshness and microbial degradation. It is a major cause of food poisoning outbreaks, triggering allergic inflammatory responses. Detecting histamine in food is crucial because its toxic threshold does not affect the food's taste, making contaminated items appear normal. To address this challenge, label‐free and bioactive‐free electrochemical sensors utilizing molecularly imprinted polymers (MIPs) offer the desired selectivity, scalability, and efficiency. MIPs are synthetic materials designed to mimic biological receptors. This paper reviews a decade of research on MIP‐assisted electrochemical sensors for histamine detection, focusing on their scalability, robustness, speed, and selectivity. The review critically analyzes the performance of these sensors in detecting histamine in food, beverages, human serum, and body diagnostics. Additionally, the current understanding of the physiological effects of endogenous and ingested histamine is reviewed, highlighting both established and emerging methods for its quantification in food and health management. The potential for transforming healthcare delivery through personalized Point‐of‐Care (POC) systems, integrated with Artificial Intelligence (AI) and Internet‐of‐Medical Things (IoMT) technologies, is also discussed.
Actuation‐Mediated Compression of a Mechanoresponsive Hydrogel by Soft Robotics to Control Release of Therapeutic Proteins
Authors: Wallace Eimear J. , O'Dwyer Joanne , Dolan Eimear B. , Burke Liam P. , Wylie Robert , Bellavia Gabriella , Straino Stefania , Cianfarani Francesca , Ciotti Gabriella , Serini Simona , Calviello Gabriella , Roche Ellen T. , Mitra Tapas , Duffy Garry P. 
Published: December 2024

AbstractTherapeutic proteins, the fastest growing class of pharmaceuticals, are subject to rapid proteolytic degradation in vivo, rendering them inactive. Sophisticated drug delivery systems that maintain protein stability, prolong therapeutic effects, and reduce administration frequency are urgently required. Herein, a mechanoresponsive hydrogel is developed contained within a soft robotic drug delivery (SRDD) device. In a step‐change from previously reported systems, pneumatic actuation of this system releases the cationic therapeutic protein Vascular Endothelial Growth Factor (VEGF) in a bioactive form which is required for therapeutic angiogenesis, the growth of new blood vessels, in numerous clinical conditions. The ability of the SRDD device to release bioactive VEGF in a spatiotemporal manner from the hydrogel is tested in diabetic rats – a model in which angiogenesis is difficult to stimulate. Daily actuation of the SRDD device in the diabetic rat model significantly increased cluster of differentiation 31+ (CD31+) blood vessel number (p = 0.0335) and the diameter of alpha‐smooth muscle actin+ (α‐SMA+) blood vessels (p = 0.0025) compared to passive release of VEGF from non‐actuated devices. The SRDD device combined with the mechanoresponsive hydrogel offers the potential to deliver an array of bioactive therapeutics in a spatiotemporal manner to mimic their natural release in vivo.