bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of esophageal stents to relieve dysphagia during neoadjuvant therapy prior to esophageal resection: a systematic review
Authors: Ahmed O , Bolger J C , O’Neill B , Robb W B 
Published: December 2019

Summary
Esophageal cancer stenting offers symptomatic relief for patients suffering from dysphagia. There are limited data to support their use to relieve dysphagia and improve nutrition during neoadjuvant therapy with some concern that they may negatively impact oncological outcomes. The aim of this systematic review was to quantify the impact of esophageal stents on outcomes prior to resection with curative intent. A literature search was performed using Embase, Medline, PubMed, PubMed Central, the Cochrane library for articles pertaining to esophageal stent use prior to or during neoadjuvant chemotherapy or chemoradiotherapy in patients planned for curative esophagectomy. Data extracted included basic demographics, clinical, nutritional and oncologic outcomes. A total of 9 studies involving 465 patients were included. Esophageal stent use resulted in a significant improvement in mean dysphagia scores in the immediate post stent period but failed to demonstrate any positive changes in weight, body mass index (BMI) or albumin. Only 33% of stented patients ultimately progressed to potential curative surgical resection and stents were associated with reduced R0 resection rates and lower overall survival. This systematic review shows that, although esophageal stenting is associated with improvements in dysphagia during neoadjuvant therapy, their effect on improving patient nutritional status is less clear and they may be associated with poorer long-term oncological outcomes. Stents should be used with caution in patients who are being considered for potentially curative resection of esophageal malignancies and other strategies of nutritional supplementation should be considered.
Selective Sampling with Information-Storage Constraints
Authors: Jehiel Philippe , Steiner Jakub 
Published: December 2019

AbstractA memoryless agent can acquire arbitrarily many signals. After each signal observation, she either terminates and chooses an action, or she discards her observation and draws a new signal. By conditioning the probability of termination on the information collected, she controls the correlation between the payoff state and her terminal action. We provide an optimality condition for the emerging stochastic choice. The condition highlights the benefits of selective memory applied to the extracted signals. Implications—obtained in simple examples—include (i) confirmation bias, (ii) speed-accuracy complementarity, (iii) overweighting of rare events, and (iv) salience effect.
Hyperbaric oxygen therapy in the prevention and management of tracheal and oesophageal anastomotic complications
Authors: Tapias Luis F , Wright Cameron D , Lanuti Michael , Muniappan Ashok , Deschler Daniel , Mathisen Douglas J 
Published: December 2019

Abstract

OBJECTIVES
Failure of anastomotic healing is a morbid complication after airway or oesophageal surgery. Hyperbaric oxygen therapy (HBOT) has been used extensively in the management of complex wound-healing problems. We demonstrate the use of HBOT to rescue at-risk anastomoses or manage anastomotic failures in thoracic surgery.

METHODS
Retrospective review of 25 patients who received HBOT as part of the management of tracheal or oesophageal anastomotic problems during 2007–2018. HBOT was delivered at 2 atm with 100% oxygen in 90-min sessions.

RESULTS
Twenty-three patients underwent airway resection and reconstruction while 2 patients underwent oesophagectomy. There were 16 (70%) laryngotracheal and 7 (30%) tracheal resections. Necrosis at the airway anastomosis was found in 13 (57%) patients, partial dehiscence in 2 (9%) patients and both in 6 (26%) patients. HBOT was prophylactic in 2 (9%) patients. Patients received a median of 9.5 HBOT sessions (interquartile range 5–19 sessions) over a median course of 8 days. The airway anastomosis healed in 20 of 23 (87%) patients. Overall, a satisfactory long-term airway outcome was achieved in 19 (83%) patients; 4 patients failed and required reoperation (2 tracheostomies and 1 T-tube). HBOT was used in 2 patients after oesophagectomy to manage focal necrosis or ischaemia at the anastomosis, with success in 1 patient. Complications from HBOT were infrequent and mild (e.g. ear discomfort).

CONCLUSIONS
HBOT should be considered as an adjunct in the management of anastomotic problems after airway surgery. It may also play a role after oesophagectomy. Possible mechanisms of action are rapid granulation, early re-epithelialization and angiogenesis.
Explanations for economic difficulties among old-age pensioners previously on disability pension
Authors: Polvinen Anu , Laaksonen Mikko , Rantala Juha , Palomäki Liisa-Maria , Kuivalainen Susan 
Published: December 2019

Abstract

Background
This study looks at how previous disability retirement is associated with economic difficulties in covering the costs of everyday basic necessities in old age, and the extent to which the differences in economic difficulties between old-age pensioners with previous disability pension and other old-age pensioners are mediated by health, income and life satisfaction.

Methods
The survey data includes 2227 retirees aged 63–85 who were receiving old-age pension in 2017. A quarter of them had received a disability pension before their old-age pension. Economic difficulties were measured through a subjective assessment of how difficult it was to cover the following necessities: food, housing, medication, health services, transport, phone and internet use. The odds ratios and their 95%-confidence intervals were analyzed with ordered logistic regression models.

Results
Old-age pensioners with previous disability retirement experienced more economic difficulties in covering cost of necessities than other old-age pensioners. The differences were especially large among those with a mental diagnosis. Health, pension income and life satisfaction attenuated the differences slightly. The fully adjusted odds ratio for having economic difficulties in covering the cost of medicine and health care among old-age pensioners with previous disability retirement due to mental disorders was 2.15 (95% CI 1.44–3.22) compared to other old-age pensioners without previous disability retirement.

Conclusions
Preventing disability retirement among working-age people diminishes the risk of economic difficulties in old age. More attention should be focussed especially on those with a high risk of disability retirement due to mental disorders.
The association between parity, CVD mortality and CVD risk factors among Norwegian women and men
Authors: Kravdal Øystein , Tverdal Aage , Grundy Emily 
Published: December 2019

Abstract

Background
Several studies have shown that women and men with two children have lower mortality than the childless, but there is less certainty about mortality, including CVD mortality, at higher parities and meagre knowledge about factors underlying the parity–mortality relationship.

Methods
The association between parity and CVD mortality was analyzed by estimating discrete-time hazard models for women and men aged 40–80 in 1975–2015. Register data covering the entire Norwegian population were used, and the models included a larger number of relevant sociodemographic control variables than in many previous studies. To analyze the relationship between parity and seven CVD risk factors, logistic models including the same variables as the mortality models were estimated from the CONOR collection of health surveys, linked to the register data.

Results
Men (but not women) who had four or more children had higher mortality from CVD than those with two, although this excess mortality was not observed for the heart disease sub-group. Overweight, possibly in part a result of less physical activity, seems to play a role in this. All CVD risk factors except smoking and alcohol may contribute to the relatively high CVD mortality among childless.

Conclusions
Childbearing is related to a number of well-known CVD risk factors, and becoming a parent or having an additional child is, on the whole, associated with lower—or at least not higher—CVD mortality in Norway. However, for men family sizes beyond three children are associated with increased CVD mortality, with risks of overweight one possible pathway.
Soil characteristics and land-use drive bacterial community assembly patterns
Authors: Barnett Samuel E , Youngblut Nicholas D , Buckley Daniel H 
Published: December 2019

ABSTRACTLand-use and soil characteristics drive variation in soil community composition, but the influences of these factors on dispersal and community assembly at regional scale remain poorly characterized. Land-use remains a consistent driver of soil community composition even when exhibiting patchy spatial distribution at regional scale. In addition, disturbed and early successional soils often exhibit stochastic community assembly patterns. These observations suggest local community composition is influenced by dispersal and assembly from regional species pools. We examined bacterial community assembly within agricultural cropland, old-field, and forested sites across 10 landscapes in the region around Ithaca, New York (USA). We found that the Sloan neutral model explained assembly well at regional scale (R2 = 0.763), but that both soil pH and land-use imposed selection that shaped community composition. We show that homogeneous selection was a dominant assembly process with respect to both soil pH and land-use regime, but that these two factors interacted in their effects on bacterial community assembly. We conclude that bacterial community assembly at a regional scale is driven by dispersal from regional species pools and local selection on the basis of soil pH and other soil characteristics that vary with land-use.
Listeria monocytogenes in sliced cheese and ham from retail markets in southern Brazil
Authors: Maia Darla Silveira Volcan , Haubert Louise , Würfel Simone de Fátima Rauber , Kroning Isabela Schneid , Cardoso Marisa Ribeiro de Itapema , Lopes Graciela Völz , Fiorentini Ângela Maria , da Silva Wladimir Padilha 
Published: December 2019

ABSTRACT
The aims of this study were to evaluate the occurrence of Listeria monocytogenes and Salmonella spp. in sliced cheese and ham from retail markets in southern Brazil, as well as to perform molecular characterization and to assess the antimicrobial resistance profile of the isolates. Samples (n = 160) of sliced cheese and ham were collected at retail level from the city of Pelotas, Brazil. The isolation of L. monocytogenes and Salmonella spp. was performed and the isolates were confirmed by PCR, submitted to antimicrobial susceptibility testing and pulsed-field gel electrophoresis (PFGE). Listeria monocytogenes was found in 9.4% (15/160) of the samples. All L. monocytogenes isolates were positive for the prs, inlA, inlC and inlJ genes. Salmonella spp. was not isolated. Regarding the antimicrobial susceptibility, one (6.6%) L. monocytogenes isolate was resistant to streptomycin and four (26.6%) to clindamycin. Macrorestriction analysis with ApaI and AscI enzymes yielded two major PFGE groups I and II. All L. monocytogenes isolates showed virulence genes, and some of them were resistant to clinically used antimicrobials, representing a risk to public health. Moreover, PFGE patterns with high similarity were visualized in L. monocytogenes isolates at different times, demonstrating adaptability of the pathogen at retail level in the region.
Regulatory role of pyruvate-sensing BtsSR in biofilm formation by Escherichia coli K-12
Authors: Ogasawara Hiroshi , Ishizuka Toshiyuki , Yamaji Kotaro , Kato Yuki , Shimada Tomohiro , Ishihama Akira 
Published: December 2019

ABSTRACT
Pyruvate, the key regulator in connection of a variety of metabolic pathways, influences transcription of the Escherichia coli genome through controlling the activity of two pyruvate-sensing two-component systems (TCSs), BtsSR and PyrSR. Previously, we identified the whole set of regulatory targets of PyrSR with low-affinity to pyruvate. Using gSELEX screening system, we found here that BtsSR with high-affinity to pyruvate regulates more than 100 genes including as many as 13 transcription factors genes including the csgD gene encoding the master regulator of biofilm formation. CsgD regulates more than 20 target genes including the csg operons encoding the Curli fimbriae. In addition, we identified the csgBAC as one of the regulatory targets of BtsR, thus indicating the involvement of two pyruvate-dependent regulatory pathways of the curli formation: indirect regulation by CsgD; and direct regulation by BtsR. Based on the findings of the whole set of regulatory targets by two pyruvate-sensing BtsR and PyrR, we further propose an innovative concept that the pyruvate level-dependent regulation of different gene sets takes place through two pyruvate-sensing TCS systems, high-affinity BtsSR and low-affinity PyrSR to pyruvate.
Mutational analysis of the flavinylation and binding motifs in two protein targets of the flavin transferase ApbE
Authors: Bertsova Yulia V , Serebryakova Marina V , Anashkin Victor A , Baykov Alexander A , Bogachev Alexander V 
Published: December 2019

ABSTRACT
Many flavoproteins belonging to three domain types contain an FMN residue linked through a phosphoester bond to a threonine or serine residue found in a conserved seven-residue motif. The flavinylation reaction is catalyzed by a specific enzyme, ApbE, which uses FAD as a substrate. To determine the structural requirements of the flavinylation reaction, we examined the effects of single substitutions in the flavinylation motif of Klebsiella pneumoniae cytoplasmic fumarate reductase on its modification by its own ApbE in recombinant Escherichia coli cells. The replacement of the flavin acceptor threonine with alanine completely abolished the modification reaction, whereas the replacements of conserved aspartate and serine had only minor effects. Effects of other substitutions, including replacing the acceptor threonine with serine, (a 10–55% decrease in the flavinylation degree) pinpointed important glycine and alanine residues and suggested an excessive capacity of the ApbE-based flavinylation system in vivo. Consistent with this deduction, drastic replacements of conserved leucine and threonine residues in the binding pocket that accommodates FMN residue still allowed appreciable flavinylation of the NqrC subunit of Vibrio harveyi Na+-translocating NADH:quinone oxidoreductase, despite a profound weakening of the isoalloxazine ring binding and an increase in its exposure to solvent.
Beneficial and detrimental effects of processed dietary fibers on intestinal and liver health: health benefits of refined dietary fibers need to be redefined!
Authors: Singh Vishal , Vijay-Kumar Matam 
Published: December 2019

Abstract
Consumption of processed foods—which are generally composed of nutritionally starved refined ingredients—has increased exponentially worldwide. A rise in public health awareness that low fiber intake is strongly linked to new-age disorders has spurred food manufacturers to fortify processed foods with refined dietary fibers (RDFs). Consumption of whole foods rich in natural fibers undoubtedly confers an array of health benefits. However, it is not clear whether RDFs extracted from the whole plant, kernel, and fruit peels exert similar physiological effects to their naturally occurring counterparts. Recent studies caution that RDFs are not universally beneficial and that inappropriate consumption of RDFs may risk both gastrointestinal and liver health. Herein, we briefly summarize the beneficial and detrimental effects of RDFs on digestive health and discuss the contribution of metabolites derived from microbial fermentation of RDFs in driving such positive or negative health outcomes.
A High-Quality Reference Genome Assembly of the Saltwater Crocodile, Crocodylus porosus, Reveals Patterns of Selection in Crocodylidae
Authors: Ghosh Arnab , Johnson Matthew G , Osmanski Austin B , Louha Swarnali , Bayona-Vásquez Natalia J , Glenn Travis C , Gongora Jaime , Green Richard E , Isberg Sally , Stevens Richard D , Ray David A 
Published: December 2019

AbstractCrocodilians are an economically, culturally, and biologically important group. To improve researchers’ ability to study genome structure, evolution, and gene regulation in the clade, we generated a high-quality de novo genome assembly of the saltwater crocodile, Crocodylus porosus, from Illumina short read data from genomic libraries and in vitro proximity-ligation libraries. The assembled genome is 2,123.5 Mb, with N50 scaffold size of 17.7 Mb and N90 scaffold size of 3.8 Mb. We then annotated this new assembly, increasing the number of annotated genes by 74%. In total, 96% of 23,242 annotated genes were associated with a functional protein domain. Furthermore, multiple noncoding functional regions and mappable genetic markers were identified. Upon analysis and overlapping the results of branch length estimation and site selection tests for detecting potential selection, we found 16 putative genes under positive selection in crocodilians, 10 in C. porosus and 6 in Alligator mississippiensis. The annotated C. porosus genome will serve as an important platform for osmoregulatory, physiological, and sex determination studies, as well as an important reference in investigating the phylogenetic relationships of crocodilians, birds, and other tetrapods.
Alterations in Diffusion Measures of White Matter Integrity Associated with Healthy Aging
Authors: Molloy Ciara J , Nugent Sinead , Bokde Arun L W 
Published: December 2019

AbstractThis study aimed to characterize age-related white matter changes by evaluating patterns of overlap between the linear association of age with fractional anisotropy (FA) with mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD). Specifically, we assessed patterns of overlap between diffusion measures of normal appearing white matter by covarying for white matter hyperintensity (WMH) load, as WMHs are thought to increase with age and impact diffusion measures. Seventy-nine healthy adults aged between 18 and 75 years took part in the study. Diffusion tensor imaging (DTI) data were based on 61 directions acquired with a b-value of 2,000. We found five main patterns of overlap: FA alone (15.95%); FA and RD (31.90%); FA and AD (12.99%); FA, RD, and AD (27.93%); and FA, RD, and MD (8.79%). We showed that cognitively healthy aging adults had low WMH load, which subsequently had minimal effect on diffusion measures. We discuss how patterns of overlap may reflect underlying biological changes observed with aging such as loss of myelination, axonal damage, as well as mild microstructural and chronic white matter impairments. This study contributes to understanding the underlying causes of degeneration in specific regions of the brain and highlights the importance of considering the impact of WMHs in aging studies of white matter.
Prediction of the salmon lice infestation pressure in a Norwegian fjord
Authors: Sandvik Anne D , Johnsen Ingrid A , Myksvoll Mari S , Sævik Pål N , Skogen Morten D 
Published: December 2019

AbstractA further growth in the Norwegian aquaculture industry might potentially be hampered by the conclusion that it is not environmentally sustainable. As direct measurements of the lice induced mortality on wild salmonids are impossible, the management is based on a set of high-quality and well-documented sustainability indicators. These indicators combine observations from the national Norwegian salmon lice monitoring programme with salmon lice models. Here, we have documented the quality of one of these models used to identify areas where the impact from farmed to wild salmonids is over the prescribed limit. The Hardangerfjord area has been used as a test area, but the model is general and, therefore, suitable for the rest of the coast. It is shown that the model system is robust and also can be used to test whether new knowledge gained from laboratory experiments improves the model. New findings on salmon lice behaviour at low salinities have been incorporated and the new model, consisting of a high-resolution hydrodynamic model coupled with an individual-based salmon lice model and forced with realistic input of salmon lice larvae from aquaculture farms, represents the best realization of the local potential infestation pressure on wild fish.
Birth Registration in Crisis: Exploring a Rights-Based Approach to Birth Registration through the Experience of Syrian Refugees
Authors: Elmolla Jazmine Hesham 
Published: December 2019

Abstract
The right to birth registration is protected under international human rights law. While this protection clearly confers an obligation on States to register births, it is less clear how this birth registration process should be carried out in order to ensure that individuals can realize numerous other human rights. For example, how should States register the births of children born to refugees or asylum seekers in order to give effect to the right to a nationality? The question is particularly relevant given the increasing number of people who are fleeing the many contemporary conflicts. The article investigates this question, along with the precise meaning and requirements of the right to birth registration under the International Covenant on Civil and Political Rights and the Convention on the Rights of the Child. It argues that the birth registration frameworks established by States often fail to protect the human rights of the child. Using Syrian refugees in Lebanon as a case study, the conclusion reached is that there is an urgent need for States to adopt a rights-based approach to birth registration that reflects the relationship between birth registration and other human rights.
The Brauer Group of the Universal Moduli Space of Vector Bundles Over Smooth Curves
Authors: Fringuelli Roberto , Pirisi Roberto 
Published: December 2019

AbstractWe compute the Brauer group of the universal moduli stack of vector bundles on (possibly marked) smooth curves of genus at least three over the complex numbers. As consequence, we obtain an explicit description of the Brauer group of the smooth locus of the associated moduli space of semistable vector bundles, when the genus is at least four.
Spatial Distribution of Lycorma delicatula (Hemiptera: Fulgoridae) Egg Masses on Tree-of-Heaven, Black Walnut, and Siberian Elm in North America
Authors: Liu Houping , Hartlieb Richard J 
Published: December 2019

Abstract
The spatial distribution of Lycorma delicatula (White) egg masses on three species of trees were studied in Pennsylvania. Five tree-of-heaven, five black walnut, and one Siberian elm trees were felled in early spring 2019 to sample for egg masses. Each egg mass was marked for its cardinal direction, position in the tree, height above ground, and spread from the bole. A total of 214 egg masses were found on tree-of-heaven and black walnut, with 38.3, 29.4, 22.0, and 10.3% on the north, west, south, and east quadrant, respectively. No significant difference in cardinal direction was found for either species. Equal number of egg masses were found on branches and boles on tree-of-heaven. However, significantly more egg masses were found on branches (96.5%) compared to boles (3.5%) on black walnut. Egg masses were laid at 0.30–12.92 and 0.70–17.00 m above ground, with most on boles/higher branches and middle/lower branches for tree-of-heaven and black walnut, respectively. Significant effect of height above ground was found for black walnut, with more egg masses found at 4–6 m compared to 0–2, 12–14, and 14–16 m. Significant effect of spread from the bole was found for tree-of-heaven, with more egg masses found at 0–2 m compared to 2–4 and 4–6 m. The 24 egg masses on the Siberian elm were mostly found on east quadrant branches 0–2 m above ground and within 2 m from the bole. Variation in tree branching patterns and difference in egg mass distribution of other forest pests were discussed.