bluuebunny/crossref_metadata_2025_split huggingface dataset:
One-stage posterior debridement and single-segment interbody fusion for treating mono-segmental lumbar and lumbosacral spinal tuberculosis in adults following minimum 5-year follow-up
Authors: Xu Zhenchao , Wang Xiyang , Liu Zheng 
Published: October 2020

Abstract
Background
To evaluate the mid-long-term outcomes of surgical management of mono-segmental lumbar and lumbosacral spinal tuberculosis (TB) in adults by one-stage posterior debridement, single-segment fixation, and titanium mesh cage interbody fusion.

Methods
A total of 62 patients with mono-segmental lumbar or lumbosacral spinal tuberculosis were enrolled. One-stage posterior debridement, single-segment fixation, and titanium mesh cage interbody fusion was performed. Clinical and radiographic outcomes were compared and analyzed.

Results
All patients were followed-up for an average of 75.0 ± 11.5 months and completely cured at the final follow-up. C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) returned to normal within three months postoperatively. Postoperative Japanese Orthopedic Association (JOA) score, visual analog scale (VAS) and Oswestry Disability index (ODI) were significantly improved compared with preoperative values. Bony fusion occurred after an average of 9.8 ± 2.6 months. The lordosis angle and lumbosacral angle were increased from preoperative 20.4 ± 2.9° and 14.7 ± 3.4° to postoperative 32.8 ± 3.6° and 22.4 ± 5.5°, with angle loss of 1.0 ± 0.7° and 0.8 ± 0.7° at the final follow-up, respectively. No significant differences between preoperative and postoperative adjacent segment disc height (DH) were found.

Conclusions
One-stage posterior debridement, single-segment fixation, and titanium mesh cage interbody fusion represent effective and feasible treatment option for mono-segmental lumbar and lumbosacral spinal tuberculosis in adults. This approach may preserve lumbar normal motor units and decrease adjacent segment degeneration (ASD) with the advantages of minimal invasiveness and rapid postoperative rehabilitation.
Diagnosis of hepatic glycogen storage disease patients with overlapping clinical symptoms by massively parallel sequencing: a systematic review of literature
Authors: Beyzaei Zahra , Geramizadeh Bita , Karimzadeh Sara 
Published: October 2020

Abstract
Background
Glycogen storage diseases (GSDs) with liver involvement are complex disorders with similar manifestations. Currently, the main diagnostic methods such as tissue diagnosis, either histopathology or enzyme assay, are invasive. Meanwhile, GSDs are diseases with significant genetic heterogeneity, and gene-sequencing methods can be more useful. This systematic review aims to review the literature to assess the value of massively parallel sequencing in the diagnosis of GSDs on patients with previously undiagnosed hepatic involvement.

Methods
Relevant studies identified in the MEDLINE/PubMed, EMBASE, Cochrane Library, Scopus, and Web of Science Core Collection databases up to July 2019 with no time and language restrictions. Publications were included in the review if they analyzed GSDs with hepatic involvement (GSD I, GSD III, GSD IV, GSD VI, GSD IX), using targeted gene sequencing (TGS) or exome sequencing (ES).

Results
Eleven studies were included in this systematic review. ES demonstrated a 93% diagnostic yield. These methods correctly distinguished all types of pathogenic variants. The diagnostic yield of the TGS method was around 79.7%.

Conclusions
According to our results, TGS analysis can be considered as the first-line diagnostic method with valuable results and ES can be used to diagnose complex cases of GSD with liver involvement. Overall, these molecular methods are considered as accurate diagnostic tools, which expedite correct diagnosis and treatment with significant cost-effectiveness by reducing unnecessary and inaccurate tests.

PROSPERO registration
CRD42020139931. Registered 8 January 2020.
Patient-reported outcomes on familial amyloid polyneuropathy (FAP)
Authors: Bolte Fabian J. , Langenstroer Christel , Friebel Frauke , Hüsing-Kabar Anna , Dugas Martin , Schmidt Hartmut H. 
Published: October 2020

Abstract
Background
Transthyretin familial amyloid polyneuropathy (ATTR-FAP) is a rare autosomal dominant inherited disease affecting multiple organ systems. ATTR-FAP patients’ experiences have rarely been documented. The aim of this study was to collect patient reported outcomes across different countries to assess unmet needs and challenges. An anonymous survey was conducted at the 2nd European meeting on ATTR amyloidosis in Berlin in September 2019. Survey questions captured information on demographics, clinical characteristics, diagnostic experience, quality of life, disability and ATTR-FAP management.

Results
A total of 38 ATTR-FAP patients from 15 different countries participated in the survey. ATTR-FAP had a substantial impact on patients’ day-to-day life, including difficulties in standing, walking, and participation in community activities. It also had negative effects on the mental health of patients. The survey highlighted several unmet needs and challenges from a patients’ perspective, including (i) a need for increased awareness and a standardized diagnostic pathway, (ii) a need for better treatment access and supportive care and (iii) a need for better information about research and clinical trials.

Conclusions
This global patient survey provides valuable findings to address ATTR-FAP patients’ needs and challenges in order to further the goal of patient-centered care.
Effectiveness of a home-based telerehabilitation system in patients after total hip arthroplasty: study protocol of a randomized controlled trial
Authors: Busso Chiara , Castorina Gabriele , Di Monaco Marco , Rodriguez Daniel , Mahdavi Hadis , Balocco Simone , Trucco Marco , Conti Marco , Castagna Alessandro , Minetto Marco Alessandro 
Published: October 2020

Abstract
Background
The demand for total hip arthroplasty (THA) is quickly rising given the escalating global incidence of hip osteoarthritis, and it is widely accepted that the post-surgery rehabilitation is key to optimize outcomes. The overall objective of this study is to evaluate the effectiveness of a new telerehabilitation solution, ReHub, for the physical function and clinical outcome improvement following THA. The specific aims of this manuscript are to describe the study design, protocol, content of interventions, and primary and secondary outcomes and to discuss the clinical rehabilitation impact of the expected experimental results.

Methods/design
This prospective, randomized, controlled, parallel-group trial will include 56 patients who had undergone primary THA. Patients are randomized to a control group (standard rehabilitation during the 2-week stay in the rehabilitation clinic followed by 3 weeks of unsupervised home-based rehabilitation) or an experimental group (standard rehabilitation during the 2-week stay in the rehabilitation clinic followed by 3 weeks of home-based ReHub-assisted telerehabilitation). The primary outcome is physical performance assessed through the Timed Up-and-Go (TUG) test. Secondary outcomes include independence level, pain intensity, hip disability, hip range of motion, muscle strength, and patient’s perception of clinical improvement.

Discussion
Proving the clinical and cost-effectiveness of a home-based telerehabilitation program for physical and muscle function following THA could support its systematic incorporation in post-surgical rehabilitation protocols, which should be tailored to the individual and collective needs.

Trial registration
ClinicalTrial.gov NCT04176315. Registered on 22 November 2019
Transcription factor FTZ-F1 regulates mosquito cuticular protein CPLCG5 conferring resistance to pyrethroids in Culex pipiens pallens
Authors: Xu Yang , Yang Xiaoshan , Sun Xiaohong , Li Xixi , Liu Zhihan , Yin Qi , Ma Lei , Zhou Dan , Sun Yan , Shen Bo , Zhu Changliang 
Published: October 2020

Abstract
Background
Culex pipiens pallens poses a serious threat to human health because of its widespread distribution, high carrier capacity for several arboviruses, frequent human-biting, and growth in urban environments. Pyrethroid insecticides have been mainly used to control adult Cx. pipiens pallens during outbreaks of mosquito-borne diseases. Unfortunately, mosquitoes have developed resistance, rendering the insecticides ineffective. Cuticular resistance is the primary mechanism of pyrethroid resistance. Previously, we revealed that cuticular protein of low complexity CPLCG5 is a major cuticular protein associated with deltamethrin resistance in Cx. pipiens pallens, which is enriched in the cuticle of mosquitoes’ legs and participates in pyrethroid resistance by forming a rigid matrix. However, the regulatory mechanisms of its transcription remain unknown.

Results
First, qRT-PCR analysis revealed that the expression of FTZ-F1 (encoding Fushi tarazu-Factor 1) was ~ 1.8-fold higher in the deltamethrin-resistant (DR) than deltamethrin-susceptible (DS) strains at 24 h post-eclosion (PE) and ~ 2.2-fold higher in the DR strain than in the DS strain at 48 h PE. CPLCG5 and FTZ-F1 were co-expressed in the legs, indicating that they might play an essential role in the legs. Dual luciferase reporter assays and EMSA (electrophoretic mobility shift experiments) revealed that FTZ-F1 regulates the transcription of CPLCG5 by binding to the FTZ-F1 response element (− 870/− 864). Lastly, knockdown of FTZ-F1 not only affected CPLCG5 expression but also altered the cuticle thickness and structure of the legs, increasing the susceptibility of the mosquitoes to deltamethrin in vivo.

Conclusions
The results revealed that FTZ-F1 regulates the expression of CPLCG5 by binding to the CPLCG5 promoter region, altering cuticle thickness and structure, and increasing the susceptibility of mosquitoes to deltamethrin in vivo. This study revealed part of the mechanism of cuticular resistance, providing a deeper understanding of insecticide resistance.
Awareness of cognitive decline trajectories in asymptomatic individuals at risk for AD
Authors: Cacciamani Federica , Sambati Luisa , Houot Marion , Habert Marie-Odile , Dubois Bruno , Epelbaum Stéphane ,   on behalf of the INSIGHT-PreAD study group, Audrain C. , Auffret A. , Bakardjian H. , Baldacci F. , Batrancourt B. , Benakki I. , Benali H. , Bertin H. , Bertrand A. , Boukadida L. , Cacciamani F. , Causse V. , Cavedo E. , Cherif Touil S. , Chiesa P. A. , Colliot O. , Dalla Barba G. , Depaulis M. , Dos Santos A. , Dubois B. , Dubois M. , Epelbaum S. , Fontaine B. , Francisque H. , Gagliardi G. , Genin A. , Genthon R. , Glasman P. , Gombert F. , Habert M. O. , Hampel H. , Hewa H. , Houot M. , Jungalee N. , Kas A. , Kilani M. , La Corte V. , Le Roy F. , Lehericy S. , Letondor C. , Levy M. , Lista S. , Lowrey M. , Ly J. , Makiese O. , Masetti I. , Mendes A. , Metzinger C. , Michon A. , Mochel F. , Nait Arab R. , Nyasse F. , Perrin C. , Poirier F. , Poisson C. , Potier M. C. , Ratovohery S. , Revillon M. , Rojkova K. , Santos-Andrade K. , Schindler R. , Servera M. C. , Seux L. , Simon V. , Skovronsky D. , Thiebaut M. , Uspenskaya O. , Vlaincu M. 
Published: October 2020

Abstract
Background
Lack of awareness of cognitive decline (ACD) is common in late-stage Alzheimer’s disease (AD). Recent studies showed that ACD can also be reduced in the early stages.

Methods
We described different trends of evolution of ACD over 3 years in a cohort of memory-complainers and their association to amyloid burden and brain metabolism. We studied the impact of ACD at baseline on cognitive scores’ evolution and the association between longitudinal changes in ACD and in cognitive score.

Results
76.8% of subjects constantly had an accurate ACD (reference class). 18.95% showed a steadily heightened ACD and were comparable to those with accurate ACD in terms of demographic characteristics and AD biomarkers. 4.25% constantly showed low ACD, had significantly higher amyloid burden than the reference class, and were mostly men. We found no overall effect of baseline ACD on cognitive scores’ evolution and no association between longitudinal changes in ACD and in cognitive scores.

Conclusions
ACD begins to decrease during the preclinical phase in a group of individuals, who are of great interest and need to be further characterized.

Trial registration
The present study was conducted as part of the INSIGHT-PreAD study. The identification number of INSIGHT-PreAD study (ID-RCB) is 2012-A01731-42.
Ribosome profiling in mouse hippocampus: plasticity-induced regulation and bidirectional control by TSC2 and FMRP
Authors: Hien Annie , Molinaro Gemma , Liu Botao , Huber Kimberly M. , Richter Joel D. 
Published: October 2020

Abstract
Background
Mutations in TSC2 are the most common cause of tuberous sclerosis (TSC), a disorder with a high incidence of autism and intellectual disability. TSC2 regulates mRNA translation required for group 1 metabotropic glutamate receptor-dependent synaptic long-term depression (mGluR-LTD) and behavior, but the identity of mRNAs responsive to mGluR-LTD signaling is largely unknown.

Methods
We utilized Tsc2+/− mice as a mouse model of TSC and prepared hippocampal slices from these animals. We induced mGluR-LTD synaptic plasticity in slices and processed the samples for RNA-seq and ribosome profiling to identify differentially expressed genes in Tsc2+/− and following mGluR-LTD synaptic plasticity.

Results
Ribosome profiling reveals that in Tsc2+/− mouse hippocampal slices, the expression of several mRNAs was dysregulated: terminal oligopyrimidine (TOP)-containing mRNAs decreased, while FMRP-binding targets increased. Remarkably, we observed the opposite changes of FMRP binding targets in Fmr1−/y hippocampi. In wild-type hippocampus, induction of mGluR-LTD caused rapid changes in the steady-state levels of hundreds of mRNAs, many of which are FMRP targets. Moreover, mGluR-LTD failed to promote phosphorylation of eukaryotic elongation factor 2 (eEF2) in TSC mice, and chemically mimicking phospho-eEF2 with low cycloheximide enhances mGluR-LTD in TSC mice.

Conclusion
These results suggest a molecular basis for bidirectional regulation of synaptic plasticity and behavior by TSC2 and FMRP. Our study also suggests that altered mGluR-regulated translation elongation contributes to impaired synaptic plasticity in Tsc2+/− mice.
Venous thromboembolism and COVID-19: a case report and review of the literature
Authors: Bhatt Harshil , Singh Sandeep 
Published: October 2020

Abstract
Background
Currently, there is minimal data available highlighting the prevalence of venous thromboembolism in patients infected with coronavirus disease 2019 (COVID-19). This case report with a literature review emphasizes a unique presentation of COVID-19 that is highly important for health care providers to consider when treating their patients.

Case report
A 65-year-old Caucasian male patient presented to the emergency department with a 2-day history of dyspnea on exertion after his wife’s recent diagnosis of COVID-19. He additionally had experienced a couple of episodes of self-resolving diarrhea a few days before presentation. Based on the patient’s clinical presentation and the laboratory workup identifying an elevated D-dimer, a computed tomography angiogram of the chest was obtained, which was significant for moderately large, bilateral pulmonary emboli with a saddle embolus, and an associated small, left lower lobe, pulmonary infarct. Ultrasound of the lower extremity showed non-occlusive deep vein thrombosis at the distal left femoral vein to the left popliteal vein. The patient was additionally diagnosed with COVID-19 when the results of the COVID-19 polymerase chain reaction test returned as positive. The patient was admitted to the COVID unit, and he was started on an intravenously administered, unfractionated heparin drip for management of his bilateral pulmonary emboli and deep vein thrombosis. The patient’s clinical condition improved significantly with anticoagulation, and he was observed in the hospital for 3 days, after which he was discharged home on the enoxaparin bridge with warfarin. Post-discharge telephone calls at day 10 and week 4 revealed that the patient was appropriately responding to anticoagulation treatment and had no recurrence of his symptoms related to venous thromboembolism and COVID-19.

Conclusion
As COVID-19 continues to lead to significant mortality, more data is emerging that is exposing its perplexing pathogenicity. Meanwhile, the presentation of venous thromboembolism in patients with COVID-19 remains an unusual finding. It is imperative for health care providers to be mindful of this unique association to make necessary diagnostic evaluations and provide appropriate treatment for the patients.
Research on PDMA communication system based on complete complementary sequence
Authors: Li Shufeng , Su Baoxin , Jin Libiao 
Published: October 2020

AbstractPattern division multiple access (PDMA) is a new non-orthogonal multiple access (NOMA) technology. It is proposed to meet the challenge of 5G large-scale connectivity and high-frequency spectral efficiency. Compared with traditional orthogonal multiple access (OMA), PDMA can support more users through the allocation of non-orthogonal resources. Due to perfect aperiodic correlation, complete complementary sequence (CCS) greatly improves the spectrum efficiency of the system. It has been widely used in wireless communication and radar sensing, and it still has research value in 5G. In order to apply the advantages of CCS to NOMA communication system, this paper proposes a system model of CCS spread spectrum coding based on PDMA. CCS is used as spread spectrum code to improve the performance of PDMA communication system. At the same time, on the basis of spread spectrum technology, this paper analyzes the average power allocation algorithm and water-filling power allocation algorithm, and a dynamic power allocation algorithm based on the transmission rate and practical application is proposed. The simulation results show that the system model can effectively improve the performance of the system.
Computational intelligence-based connectivity restoration in wireless sensor and actor networks
Authors: Mohammadi Solmaz , Farahani Gholamreza 
Published: October 2020

AbstractNetwork failure is categorized into the two types of software and hardware (physical layer) failure. This paper focuses on the physical layer failure in the wireless sensor and actor networks (WSANs). Actors play an important role in data processing, decision-making, and performing appropriate reactions. Single or multiple nodes failure of actors due to the explosion, energy depletion, or harsh environments, can cause multiple disjoint partitions. This paper has proposed a new computational intelligence-based connectivity restoration (CICR) method. It uses a combination of advanced computational intelligence methods to solve restoration problem. The proposed algorithm applies the novel enhanced Lagrangian relaxation with a novel metaheuristic sequential improved grey wolf optimizer (SIGWO) search space algorithm in simultaneous selection ofksponsor andppathway nodes. The reactive proposed method aims to reduce the travel distance or moving cost and communication cost. As a result, the restored network has minimum of topology change and energy consumption. In terms of total traveled distance, CICR has 37.19%, 71.47%, and 44.71% improvement in the single-node failure averagely in comparison with HCR, HCARE, and CMH, respectively. Also, it has an average of 61.54%, 40.1%, and 57.76% improvement in comparison with DCR, PRACAR, and RTN in multiple partitions resulted from multiple nodes failure, respectively. The reliability of CICR method has improved averagely by 35.85%, 38.46%, 22.03% over HCR, CMH, and HCARE in single-node failure. In multiple nodes failure, reliability of CICR has averagely 61.54% and 20% over DCR and PRACAR, respectively.
Coderivatives and Aubin property of efficient point and efficient solution set-valued maps in parametric vector optimization
Authors: Xue Xiaowei 
Published: October 2020

AbstractThe aim of this paper is computing the coderivatives of efficient point and efficient solution set-valued maps in a parametric vector optimization problem. By using a method different from the existing literature we establish an upper estimate and explicit expression for the coderivatives of an efficient point set-valued map where the independent variable can take values in the whole space. As an application, we give some characterizations on the Aubin property of an efficient point map and an explicit expression of the coderivative for an efficient solution map. We provide several examples illustrating the main results.
A new q-integral identity and estimation of its bounds involving generalized exponentially μ-preinvex functions
Authors: Awan Muhammad Uzair , Talib Sadia , Kashuri Artion , Noor Muhammad Aslam , Noor Khalida Inayat , Chu Yu-Ming 
Published: October 2020

AbstractIn the article, we introduce the generalized exponentially μ-preinvex function, derive a new q-integral identity for second order q-differentiable function, and establish several new q-trapezoidal type integral inequalities for the function whose absolute value of second q-derivative is exponentially μ-preinvex.
The need for financial knowledge acquisition tools and technology by small business entrepreneurs
Authors: Rachapaettayakom Panita , Wiriyapinit Mongkolchai , Cooharojananone Nagul , Tanthanongsakkun Suparatana , Charoenruk Nuttirudee 
Published: October 2020

AbstractKnowledge management tools and technology are the main factors bringing competitive advantage to organisations. This study extends the depth of study on small business entrepreneurs by examining the effect of knowledge acquisition, in particular financial knowledge that leads to the need for knowledge acquisition tools and technology. There is evidence to support that a lower level of existing financial knowledge in small business entrepreneurs encourages them to acquire more financial knowledge since they tend to be responsible for all tasks related to business survival. This finding is not consistent with several other previous studies. In addition, relevant knowledge on how to raise adequate capital to establish their business and the accurate calculation of cost are the two most important aspects of financial knowledge for encouraging small business entrepreneurs to seek effective knowledge acquisition tools and technology. The evidence provides insight for the government authorities supporting small businesses to provide financial knowledge to small business entrepreneurs during the pre-start-up phase and thereafter by providing the relevant knowledge on financing and cost calculation to strengthen and sustain these businesses. This will ultimately lead to an improvement in small business failure and increase the country’s economic growth.