bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Deplorable Exegesis”: Dick Gregory's Irreverent Scriptural Authority in the 1960s and 1970s
Authors: Booker Vaughn A. 
Published: August 2020

ABSTRACTThis article examines comedian Richard Claxton “Dick” Gregory's comical articulation of religious belief and belonging through his speeches and religious writings during the 1960s and 1970s. It argues that, during his most visible public presence as an activist and comedic entertainer, Gregory bore an irreverent scriptural authority for his readers and comedy audiences who sought a prominent, public affirmation of their suspicion and criticism of religious authorities and conventional religious teachings. This suspicion would allow them to grapple with the oppressive presence of religion in the long history of Western colonialism, in the U.S. context of slavery, and in the violence and segregation of Jim Crow America. Following this religious suspicion, however, Gregory's consistent goal was to implement just social teachings stemming from socially and theologically progressive readings of the Hebrew Bible and of the teachings of Jesus in the Gospels. Gregory's irreverence modeled, and reflected, the maintenance of belief in both the divine and in the justness of remaking an oppressive, violent, unequal world through nonviolent activism in accordance with his understanding of the teachings of the King James scriptures that he read throughout his life. This study of comedy uses one African American male's production of irreverent, authoritative religious rhetoric to display a noteworthy mode of mid-century African American religious liberalism. It is also a case study highlighting the complexity of religious belief and affiliation. Despite acknowledged ambivalences about his commitments to religion, Gregory also modeled ways for audiences to reframe religious commitments to produce social change.
Impact of improving eating habits and rosmarinic acid supplementation on rat vascular and neuronal system in the metabolic syndrome model
Authors: Michalikova D. , Tyukos Kaprinay B. , Brnoliakova Z. , Sasvariova M. , Krenek P. , Babiak E. , Frimmel K. , Bittner Fialova S. , Stankovicova T. , Sotnikova R. , Gasparova Z. 
Published: August 2020

AbstractDecreasing high fat and high carbohydrate intake, together with the administration of natural bioactive drugs, is assumed to have a protective effect in the prevention and amelioration of the metabolic syndrome (MetS). The aim of the study was to evaluate effects of diet improvement and/or a phenolic compound (rosmarinic acid; RA) administration (100 mg/kg per d) on metabolic as well as functional changes of vessels and hippocampus caused by the MetS-like conditions. The MetS-like conditions were induced by a high-fat-fructose diet (HFFD) in Prague hereditary hypertriacylglycerolaemic (HTG) rats. The effect of diet improvement and RA administration was studied using biochemical and functional measurements. Consumption of HFFD by HTG rats resulted in the development of conditions like the MetS. The fat and fructose restriction from the diet led to amelioration of basic indicators of metabolic state in rats fed HFFD and to amendment parameters of glucose tolerance test and reduction of the IL-1β serum levels. Moreover, aortic endothelial function was improved with an impact on blood pressure. The functional measurement of electrophysiology of the hippocampus showed that long-term potentiation of neuronal transmission course deteriorated after HFFD was improved by energy restriction. Oral administration of RA had a supporting effect not only on lipid and glucose metabolism but also on the vascular endothelium. Combination of both types of therapy induced beneficial effect on glucose tolerance and lipid peroxidation. Thus, combined improvement of diet habits and treatment with natural bioactive drugs is assumed to have protective effect in prevention and amelioration of the MetS.
Forsterite reprecipitation and carbon dioxide entrapment in the lithospheric mantle during its interaction with carbonatitic melt: a case study from the Sung Valley ultramafic–alkaline–carbonatite complex, Meghalaya, NE India
Authors: Choudhary Shubham , Sen Koushik , Kumar Santosh , Rana Shruti , Ghosh Swakangkha 
Published: August 2020

AbstractCarbonatite melts derived from the mantle are enriched in CO2- and H2O-bearing fluids. This melt can metasomatize the peridotitic lithosphere and liberate a considerable amount of CO2. Experimental studies have also shown that a CO2–H2O-rich fluid can form Fe- and Mg-rich carbonate by reacting with olivine. The Sung Valley carbonatite of NE India is related to the Kerguelen plume and is characterized by rare occurrences of olivine. Our study shows that this olivine is resorbed forsterite of xenocrystic nature. This olivine bears inclusions of Fe-rich magnesite. Accessory apatite in the host carbonatite contains CO2–H2O fluid inclusions. Carbon and oxygen isotopic analyses indicate that the carbonatites are primary igneous carbonatites and are devoid of any alteration or fractionation. We envisage that the forsterite is a part of the lithospheric mantle that was reprecipitated in a carbonatite reservoir through dissolution–precipitation. Carbonation of this forsterite, during interaction between the lithospheric mantle and carbonatite melt, formed Fe-rich magnesite. CO2–H2O-rich fluid derived from the carbonatite magma and detected within accessory apatite caused this carbonation. Our study suggests that a significant amount of CO2degassed from the mantle by carbonatitic magma can become entrapped in the lithosphere by forming Fe- and Mg-rich carbonates.
Comparison of local knowledge and researcher-led observations for wildlife exploitation assessment and management
Authors: Temple Andrew J , Stead Selina M , Hind-Ozan Edward , Jiddawi Narriman , Berggren Per 
Published: August 2020

SummaryThe use of local knowledge observations to generate empirical wildlife resource exploitation data in data-poor, capacity-limited settings is increasing. Yet, there are few studies quantitatively examining their relationship with those made by researchers or natural resource managers. We present a case study comparing intra-annual patterns in effort and mobulid ray (Mobula spp.) catches derived from local knowledge and fisheries landings data at identical spatiotemporal scales in Zanzibar (Tanzania). The Bland–Altman approach to method comparison was used to quantify agreement, bias and precision between methods. Observations from the local knowledge of fishers and those led by researchers showed significant evidence of agreement, demonstrating the potential for local knowledge to act as a proxy, or complement, for researcher-led methods in assessing intra-annual patterns of wildlife resource exploitation. However, there was evidence of bias and low precision between methods, undermining any assumptions of equivalency. Our results underline the importance of considering bias and precision between methods as opposed to simply assessing agreement, as is commonplace in the literature. This case study demonstrates the value of rigorous method comparison in informing the appropriate use of outputs from different knowledge sources, thus facilitating the sustainable management of wildlife resources and the livelihoods of those reliant upon them.
Calculating correct compilers II: Return of the register machines
Authors: BAHR PATRICK , HUTTON GRAHAM 
Published: August 2020

AbstractIn ‘Calculating Correct Compilers’ (Bahr & Hutton, 2015), we developed a new approach to calculating compilers directly from specifications of their correctness. Our approach only required elementary reasoning techniques and has been used to calculate compilers for a wide range of language features and their combination. However, the methodology was focused on stack-based target machines, whereas real compilers often target register-based machines. In this article, we show how our approach can naturally be adapted to calculate compilers for register machines.
A Lithosphere‐Asthenosphere Boundary and Partial Melt Estimated Using Marine Magnetotelluric Data at the Central Middle Atlantic Ridge
Authors: Wang Shunguo , Constable Steven , Rychert Catherine A. , Harmon Nicholas 
Published: August 2020

AbstractThe differential motion between the lithosphere and the asthenosphere is aseismic, so the magnetotelluric (MT) method plays an important role in studying the depth and nature of the lithosphere‐asthenosphere boundary (LAB). In March 2016, we deployed 39 marine MT instruments across the Middle Atlantic Ridge (MAR), 2,000 km away from the African coast, to study the evolution of the LAB with ages out to 45 million years (My). The MT acquisition time was limited to about 60 days by battery life. After analyzing dimensionality and coast effects for the MT data, determinant data were inverted for two‐dimensional resistivity models along two profiles north and south of the Chain Fracture Zone (CFZ). The imaged thickness of the lithospheric lid (>100 Ωm) ranges from 20 to 80 km, generally thickening with age. In the north of CFZ, punctuated low‐resistivity anomalies (<1 Ωm), likely associated with potential partial melts, occur along its base. In the south of CFZ, the base of the resistive lid is demarcated by a low‐resistivity channel (<1 Ωm) most likely fed by deeper melts. Sensitivity analyses and structural recovery tests indicate the robustness of these features. Resistivity models are in good agreement with results of seismic data. These results imply that partial melt is persistent over geologic timescales and that the LAB is dynamic features fed by upward percolation of mantle melt. The melt fraction is about 1–7% based on the resistivity, temperature, pressure, and hydrous basalt models, which is consistent with petrophysical observations.
Prognostic value of depression and anxiety on breast cancer recurrence and mortality: a systematic review and meta-analysis of 282,203 patients
Authors: Wang Xuan , Wang Neng , Zhong Lidan , Wang Shengqi , Zheng Yifeng , Yang Bowen , Zhang Juping , Lin Yi , Wang Zhiyu 
Published: August 2020

AbstractDepression and anxiety are common comorbidities in breast cancer patients. Whether depression and anxiety are associated with breast cancer progression or mortality is unclear. Herein, based on a systematic literature search, 17 eligible studies involving 282,203 breast cancer patients were included. The results showed that depression was associated with cancer recurrence [1.24 (1.07, 1.43)], all-cause mortality [1.30 (1.23, 1.36)], and cancer-specific mortality [1.29 (1.11, 1.49)]. However, anxiety was associated with recurrence [1.17 (1.02, 1.34)] and all-cause mortality [1.13 (1.07, 1.19)] but not with cancer-specific mortality [1.05 (0.82, 1.35)]. Comorbidity of depression and anxiety is associated with all-cause mortality [1.34 (1.24, 1.45)] and cancer-specific mortality [1.45 (1.11, 1.90)]. Subgroup analyses demonstrated that clinically diagnosed depression and anxiety, being female and of younger age (<60 years), and shorter follow-up duration (≤5 years) were related to a poorer prognosis. Our study highlights the critical role of depression/anxiety as an independent factor in predicting breast cancer recurrence and survival. Further research should focus on a favorable strategy that works best to improve outcomes among breast cancer patients with mental disorders.
Decomposing the molecular complexity of brewing
Authors: Pieczonka Stefan A. , Lucio Marianna , Rychlik Michael , Schmitt-Kopplin Philippe 
Published: August 2020

AbstractThe compositional space of a set of 120 diverse beer samples was profiled by rapid flow-injection analysis (FIA) Fourier transform ion cyclotron mass spectrometry (FTICR-MS). By the unrivaled mass resolution, it was possible to uncover and assign compositional information to thousands of yet unknown metabolites in the beer matrix. The application of several statistical models enabled the assignment of different molecular pattern to certain beer attributes such as the beer type, the way of adding hops and the grain used. The dedicated van Krevelen diagrams and mass difference networks displayed the structural connectivity of the annotated sum formulae. Thereby it was possible to provide a base of knowledge of the beer metabolome far above database-dependent annotations. Typical metabolic signatures for beer types, which reflect differences in ingredients and ways of brewing, could be extracted. Besides, the complexity of isomeric compounds, initially profiled as single mass values in fast FIA-FTICR-MS, was resolved by selective UHPLC-ToF-MS2 analysis. Thereby structural hypotheses based on FTICR’s sum formulae could be confirmed. Benzoxazinoid hexosides deriving from the wheat’s secondary metabolism were uncovered as suitable marker substances for the use of whole wheat grains, in contrast to merely wheat starch or barley. Furthermore, it was possible to describe Hydroxymethoxybenzoxazinone(HMBOA)-hexosesulfate as a hitherto unknown phytoanticipin derivative in wheat containing beers. These findings raise the potential of ultrahigh resolution mass spectrometry for rapid quality control and inspection purposes as well as deep metabolic profiling, profound search for distinct hidden metabolites and classification of archeological beer samples.
Evidence of diet, deification, and death within ancient Egyptian mummified animals
Authors: Johnston Richard , Thomas Richard , Jones Rhys , Graves-Brown Carolyn , Goodridge Wendy , North Laura 
Published: August 2020

AbstractThe clues to life and death of mummified animals can remain hidden beneath their wrappings. Developments in non-invasive imaging have enabled detailed study of their internal structures. Laboratory-based X-ray microcomputed tomography (microCT) and focussed imaging protocols permit smaller mummified remains, such as animals, to be studied at higher resolution. In this study, we use microCT to image three different animal mummies. Revealing the internal structures provides insights into their biography, the conditions in which they were kept, complex mummification practices, possible causes of death, and subsequent handling damage. Thousands of years after the production of these mummified animals, the X-ray microCT technique facilitates new investigations, revealing ‘harder’ skeletal structures, mummification materials, and even desiccated soft tissues. Potential evidence for an ‘opening of the mouth’ procedure was found in a snake, along with indicators of the poor conditions in which the snake was kept when alive, leading to dehydration. Examination of a cat mummy revealed it was less than five months old and had its neck purposefully broken. It was also possible to identify a bird mummy to species level from the X-ray data. Improved understanding of animal mummification through scientific imaging can thus inform conservation and understanding of past human-animal relationships.
Cranial evolution in the extinct Rodrigues Island owl Otus murivorus (Strigidae), associated with unexpected ecological adaptations
Authors: Duhamel Anaïs , Hume Julian P. , Guenser Pauline , Salaviale Céline , Louchart Antoine 
Published: August 2020

AbstractIsland birds that were victims of anthropic extinctions were often more specialist species, having evolved their most distinctive features in isolation, making the study of fossil insular birds most interesting. Here we studied a fossil cranium of the ‘giant’ extinct scops owl Otus murivorus from Rodrigues Island (Mascarene Islands, southwestern Indian Ocean), to determine any potential unique characters. The fossil and extant strigids were imaged through X-ray microtomography, providing 3D views of external and internal (endocast, inner ear) cranial structures. Geometric morphometrics and analyses of traditional measurements yielded new information about the Rodrigues owl’s evolution and ecology. Otus murivorus exhibits a 2-tier “lag behind” phenomenon for cranium and brain evolution, both being proportionately small relative to increased body size. It also had a much more developed olfactory bulb than congeners, indicating an unexpectedly developed olfactory sense, suggesting a partial food scavenging habit. In addition, O. murivorus had the eyes placed more laterally than O. sunia, the species from which it was derived, probably a side effect of a small brain; rather terrestrial habits; probably relatively fearless behavior; and a less vertical posture (head less upright) than other owls (this in part an allometric effect of size increase). These evolutionary features, added to gigantism and wing reduction, make the extinct Rodrigues owl’s evolution remarkable, and with multiple causes.
C57BL/6J substrain differences in response to high-fat diet intervention
Authors: Siersbæk Majken Storm , Ditzel Nicholas , Hejbøl Eva Kildall , Præstholm Stine Marie , Markussen Lasse Kruse , Avolio Fabio , Li Lingzi , Lehtonen Lasse , Hansen Axel Kornerup , Schrøder Henrik Daa , Krych Lukasz , Mandrup Susanne , Langhorn Louise , Bollen Peter , Grøntved Lars 
Published: August 2020

AbstractC57BL/6J-related mouse strains are widely used animal models for diet-induced obesity (DIO). Multiple vendors breed C57BL/6J-related substrains which may introduce genetic drift and environmental confounders such as microbiome differences. To address potential vendor/substrain specific effects, we compared DIO of C57BL/6J-related substrains from three different vendors: C57BL/6J (Charles Rivers), C57BL/6JBomTac (Taconic Bioscience) and C57BL/6JRj (Janvier). After local acclimatization, DIO was induced by either a high-fat diet (HFD, 60% energy from fat) or western diet (WD, 42% energy from fat supplemented with fructose in the drinking water). All three groups on HFD gained a similar amount of total body weight, yet the relative amount of fat percentage and mass of inguinal- and epididymal white adipose tissue (iWAT and eWAT) was lower in C57BL/6JBomTac compared to the two other C57BL/6J-releated substrains. In contrast to HFD, the three groups on WD responded differently in terms of body weight gain, where C57BL/6J was particularly prone to WD. This was associated with a relative higher amount of eWAT, iWAT, and liver triglycerides. Although the HFD and WD had significant impact on the microbiota, we did not observe any major differences between the three groups of mice. Together, these data demonstrate significant differences in HFD- and WD-induced adiposity in C57BL/6J-related substrains, which should be considered in the design of animal DIO studies.
Early-life short-term environmental enrichment counteracts the effects of stress on anxiety-like behavior, brain-derived neurotrophic factor and nuclear translocation of glucocorticoid receptors in the basolateral amygdala
Authors: Hegde Akshaya , Suresh Shruti , Mitra Rupshi 
Published: August 2020

AbstractEarly life is a decisive stage for the development of physiological and psychological characteristics of an individual. Any stress or disruption of healthy development at this stage has serious long-lasting consequences for the remaining life. Unfortunately, early life stress is a common occurrence in humans and other animals. In this context, we investigated if the provision of environmental enrichment during the pre-weaning phase of rat pups and dams could alter the consequences of early-life maternal-separation stress. Pre-weaning enrichment rescued the effects of maternal separation on the excess secretion of adrenal stress hormones and anxiety-like behavior during adulthood. Enrichment also reduced the effect of stress on the spine density of basolateral amygdala neurons, a brain region critical for stress-induced facilitation of emotional behaviors. Pre-weaning enrichment, provided during early-life, blunted the effects of maternal separation stress on decreased intra-nuclear translocation of glucocorticoid receptors within the amygdala neurons when tested later in adulthood. Early-life, pre-weaning environmental enrichment also increased the amount of brain-derived neurotrophic factor within adult basolateral amygdala. Our observations showed that environmental manipulation during early formative years could be utilized to build lifelong resilience to stress. Complex naturalistic housing and sensory enrichment is, thus, an useful buffer against an impoverished and stressful childhood.
Elucidation of resistance signaling and identification of powdery mildew resistant mapping loci (ClaPMR2) during watermelon-Podosphaera xanthii interaction using RNA-Seq and whole-genome resequencing approach
Authors: Mandal Mihir Kumar , Suren Haktan , Kousik Chandrasekar 
Published: August 2020

AbstractWatermelon is an important vegetable crop and is widely cultivated in USA with an approximate global production of > 100 million tons. Powdery mildew (PM) caused by Podosphaera xanthii is a major production-limiting factor on watermelon and other cucurbits. Numerous PM and multiple disease resistant (MDR) watermelon germplasm lines have been developed by the USDA in Charleston, SC. To gain a better understanding of the innate and activated molecular defense mechanisms involved during compatible and incompatible PM-watermelon interactions, we inoculated PM susceptible (USVL677-PMS) and resistant (USVL531-MDR) watermelon plants with 105 conidia ml−1 of P. xanthii. RNA-seq profiling was done on leaf samples collected at 0, 1, 3, and 8 days post inoculation (DPI). A total of 2,566 unique differentially expressed genes (DEGs) were identified between compatible and incompatible interactions with P. xanthii. The compatible interactions resulted in distinct plant gene activation (> twofold unique transcripts, 335:191:1762 :: 1:3:8 DPI) as compared to incompatible interaction (> twofold unique transcripts, 314:681:487 :: 1:3:8 DPI). Further, comparative whole-genome resequencing analysis of USVL531-PMR, USVL677-PMS and four introgressed PM resistant recombinant inbred lines (RIL, USVL531-PMR × USVL677-PMS) were performed to identify the region of PM resistance introgressed break points along with other traits inherent by USVL531-PMR by comparing the SNPs and InDels. Based on SNPs identification and CAPS markers, the resistance gene was identified as ClaPMR2, Citrullus lanatus PM Resistance gene 2 {Chr2 : 26750001 .. 26753327 (−)}, a NBS-LRR resistance protein (R) with homology to the Arabidopsis thaliana PM resistance protein, RPW8. The transcriptome data also revealed a complex regulatory network associated with the introgressed junctions mediated by PM resistance R proteins (R genes) that may involve multiple signal regulators and transducers, carbohydrate metabolism, cell wall modifications and the hormone-signaling pathway.
A droplet reactor on a super-hydrophobic surface allows control and characterization of amyloid fibril growth
Authors: Zhang Peng , Moretti Manola , Allione Marco , Tian Yuansi , Ordonez-Loza Javier , Altamura Davide , Giannini Cinzia , Torre Bruno , Das Gobind , Li Erqiang , Thoroddsen Sigurdur T. , Sarathy S. Mani , Autiero Ida , Giugni Andrea , Gentile Francesco , Malara Natalia , Marini Monica , Di Fabrizio Enzo 
Published: August 2020

AbstractMethods to produce protein amyloid fibrils, in vitro, and in situ structure characterization, are of primary importance in biology, medicine, and pharmacology. We first demonstrated the droplet on a super-hydrophobic substrate as the reactor to produce protein amyloid fibrils with real-time monitoring of the growth process by using combined light-sheet microscopy and thermal imaging. The molecular structures were characterized by Raman spectroscopy, X-ray diffraction and X-ray scattering. We demonstrated that the convective flow induced by the temperature gradient of the sample is the main driving force in the growth of well-ordered protein fibrils. Particular attention was devoted to PHF6 peptide and full-length Tau441 protein to form amyloid fibrils. By a combined experimental with the molecular dynamics simulations, the conformational polymorphism of these amyloid fibrils were characterized. The study provided a feasible procedure to optimize the amyloid fibrils formation and characterizations of other types of proteins in future studies.