bluuebunny/crossref_metadata_2025_split huggingface dataset:
Controleren van gemeentelijke samenwerking
Authors: Peters Klaartje 
Published: February 2020

Controleren van gemeentelijke samenwerking. Een blik op interbestuurlijk toezicht vanuit het perspectief van gemeenteraden
Gemeenteraden worstelen met hun controlerende taak, zeker ten aanzien van de grote regionale samenwerkingsverbanden zoals de Veiligheidsregio, de GGD en de Omgevingsdienst. De kwaliteit van de informatievoorziening over prestaties van die verbanden is een belangrijk knelpunt. Bij nadere beschouwing blijkt dat Rijksinspecties en de provincies in hun rol als interbestuurlijk toezichthouder regelmatig onderzoek doen naar gemeenten en hun samenwerkingsverbanden dat voor gemeenteraden uiterst bruikbaar is. Gemeenteraden lijken daar weinig gebruik van te maken, deels doordat zij niet worden geïnformeerd over de onderzoeken en de resultaten ervan. Dat moet veranderen: er moet bij toezichthouders meer oog komen voor het belang van gemeenteraden als eerste controleur van het gemeentebestuur.
Extraction of Novel Features Based on Histograms of MFCCs Used in Emotion Classification from Generated Original Speech Dataset
Authors: Pakyurek Muhammet , Atmis Mahir , Kulac Selman , Uludag Umut 
Published: February 2020

This paper introduces two significant contributions: one is a new feature based on histograms of MFCC (Mel-Frequency Cepstral Coefficients) extracted from the audio files that can be used in emotion classification from speech signals, and the other – our new multi-lingual and multi-personal speech database, which has three emotions. In this study, Berlin Database (BD) (in German) and our custom PAU database (in English) created from YouTube videos and popular TV shows are employed to train and evaluate the test results. Experimental results show that our proposed features lead to better classification of results than the current state-of-the-art approaches with Support Vector Machine (SVM) from the literature. Thanks to our novel feature, this study can outperform a number of MFCC features and SVM classifier based studies, including recent researches. Due to the lack of our novel feature based approaches, one of the most common MFCC and SVM framework is implemented and one of the most common database Berlin DB is used to compare our novel approach with these kind of approaches.
Mutantdlx3bdisturbs normal tooth mineralization and bone formation in zebrafish
Authors: Pang Liping , Zhang Zhichun , Shen Yan , Cheng Zhenchao , Gao Xuejun , Zhang Bo , Wang Xiaoyan , Tian Hua 
Published: February 2020

BackgroundTricho-dento-osseous (TDO) syndrome is an autosomal dominant disorder characterized by anomalies in hair, teeth and bone (OMIM190320). Various mutations of Distal-Less 3 (DLX3) gene are found to be responsible for human TDO. The aim of this study was to investigate effects ofDLX3on tooth and bone development using a zebrafish model.MethodsThedlx3bmutant zebrafish lines were established using the gene targeting tool transcription activator-like effector nuclease (TALEN). Micro-computed tomography was used to render the three-dimensional skeletal structures of mutant fishes. The pharyngeal bone along with connected teeth was isolated and stained by Alizarine Red S, then observed under stereomicroscope. Scanning electron microscopy (SEM) and energy dispersive spectrometer (EDS) were used to examine the tooth surface morphology and mineral composition. Quantitative real-time PCR was used to analyze gene expression.ResultsA moderate curvature of the spine toward the dorsal side was found at the early larval stages, appearing in 86 out of 100 larvae indlx3b-/-group as compared to 3 out of 99 in thedlx3b+/+group. At the adult stage, three of the thirtydlx3b-/-homozygotes exhibited prominent abnormal curvature in the spine. SEM revealed morphological surface changes in pharyngeal teeth enameloid, accompanied by a decrease in the mineral content detected by EDS. Furthermore, specific secretory calcium-binding phosphoprotein (SCPP) genes, includingodam,scpp9,spp1,scpp1, andscpp5were significantly downregulated indlx3bmutants.ConclusionThe findings of this study suggest thatdlx3bis critical for enamel mineralization and bone formation in zebrafish. Moreover, the discovery of the downregulation of SCPP genes indlx3bmutants sheds new light on the molecular mechanisms underlying TDO syndrome.
SCelVis: exploratory single cell data analysis on the desktop and in the cloud
Authors: Obermayer Benedikt , Holtgrewe Manuel , Nieminen Mikko , Messerschmidt Clemens , Beule Dieter 
Published: February 2020

Background
Single cell omics technologies present unique opportunities for biomedical and life sciences from lab to clinic, but the high dimensional nature of such data poses challenges for computational analysis and interpretation. Furthermore, FAIR data management as well as data privacy and security become crucial when working with clinical data, especially in cross-institutional and translational settings. Existing solutions are either bound to the desktop of one researcher or come with dependencies on vendor-specific technology for cloud storage or user authentication.

Results
To facilitate analysis and interpretation of single-cell data by users without bioinformatics expertise, we present SCelVis, a flexible, interactive and user-friendly app for web-based visualization of pre-processed single-cell data. Users can survey multiple interactive visualizations of their single cell expression data and cell annotation, define cell groups by filtering or manual selection and perform differential gene expression, and download raw or processed data for further offline analysis. SCelVis can be run both on the desktop and cloud systems, accepts input from local and various remote sources using standard and open protocols, and allows for hosting data in the cloud and locally. We test and validate our visualization using publicly available scRNA-seq data.

Methods
SCelVis is implemented in Python using Dash by Plotly. It is available as a standalone application as a Python package, via Conda/Bioconda and as a Docker image. All components are available as open source under the permissive MIT license and are based on open standards and interfaces, enabling further development and integration with third party pipelines and analysis components. The GitHub repository is https://github.com/bihealth/scelvis.
Structured Lipids and Health
Authors: Akoh Casimir C. , Pande Garima 
Published: February 2020

AbstractLipids play a pivotal role in human health, growth, and development. The application challenges presented by lipids in their natural form are overcome by production of customized lipids, called structured lipids (SLs). The changes in the triacylglycerol (TAG) molecular species alter their physicochemical as well as nutritional properties. Advances have been made in the area of SL synthesis and applications. Novel SLs enriched with different fatty acids (FAs) have been synthesized for a wide range of medicinal and nutritional applications. The amount of fat and its concentration, type, and stereospecificity of FAs is critical for its metabolism and bioavailability. The correlations of dietary lipids with different diseases and their importance in maintaining homeostasis and overall health are becoming increasingly clear with emerging studies. SLs are beneficial in chronic health conditions, enteral and parental nutrition, infant formulas, sports nutrition, and low calorie fats. This review focusses on the effects of SLs on various health aspects.
Conjugation of Virulence Plasmid in Clinical Klebsiella pneumoniae Strains through Formation of a Fusion Plasmid
Authors: Xie Miaomiao , Chen Kaichao , Ye Lianwei , Yang Xuemei , Xu Qi , Yang Chen , Dong Ning , Chan Edward Wai‐Chi , Sun Qiaoling , Shu Lingbin , Gu Danxia , Lin Xiaodong , Zhang Rong , Chen Sheng 
Published: February 2020

AbstractThe rapid dissemination of non‐conjugative virulence plasmids among non‐K1/K2 types of Klebsiella pneumoniae poses an unprecedented threat to human health, yet the underlying mechanisms governing dissemination of such plasmids is unclear. In this study, a novel 68 581 bp IncFIA plasmid is discovered that can be fused to a hypervirulence‐encoding plasmid to form a hybrid conjugative virulence plasmid in conjugation experiments; such fusion events involve homologous recombination between a 241 bp homologous region located in each of the two plasmids. The fusion hypervirulence‐encoding plasmid can be conjugated to both classic and blaKPC‐2‐bearing carbapenem‐resistant K. pneumoniae strains through conjugation, enabling such strains to acquire the ability to express the hypervirulence phenotype. Dissemination of this fusion virulence plasmid will impose an enormous burden on current efforts to control and treat infections caused by multidrug resistant and hypervirulent K. pneumoniae.
Autonomously Self‐Reporting Hard Coatings: Tracking the Temporal Oxidation Behavior of TiN by In Situ Sheet Resistance Measurements
Authors: Stelzer Bastian , Momma Markus , Schneider Jochen M. 
Published: February 2020

AbstractMonitoring the structural health and integrity of coated components is of vital importance to increase their lifetime and the overall sustainability of the targeted applications. Here, the temporal oxidation behavior of TiN thin films is tracked using in situ sheet resistance measurements. Based on correlative film morphology, structure, and local composition data, it is evident that observed resistance changes are caused by oxidation of TiN. Thickness measurements of the remaining TiN under the oxide layer are in very good agreement with thicknesses deduced from in situ sheet resistance measurements. Hence, the in situ measured sheet resistance is an autonomous self‐reporting property useful for tracking the temporal oxidation behavior of TiN coatings.
Pd‐Catalyzed Annulation of β‐Iodovinyl Sulfones with 2‐Halophenols: A General Route for the Synthesis of 3‐Sulfonyl Benzofuran Derivatives
Authors: Reddy Raju Jannapu , Kumar Jangam Jagadesh , Kumari Arram Haritha , Krishna Gamidi Rama 
Published: February 2020

AbstractThe palladium‐catalyzed annulation between β‐iodovinyl sulfones and 2‐halophenols or 1‐bromo‐2‐naphthol or 2‐bromo‐3‐pyridinol is presented. The annulation process involving oxa‐Michael addition‐elimination and intramolecular Heck reaction leading to form 2,3‐disubstituted benzofurans (aryl benzofuryl sulfones) in good to high yields. The regioselective tandem construction of C−O and C−C bonds has been achieved with a variety of substitution patterns. Moreover, the tandem process is reliable at gram‐scale reactions and a plausible mechanism is also proposed.magnified image
Ultrasensitive Multilayer MoS2‐Based Photodetector with Permanently Grounded Gate Effect
Authors: Naqi Muhammad , Kaniselvan Manasa , Choo Sooho , Han Gyuchull , Kang Sangjin , Kim Jeonghun , Yoon Youngki , Kim Sunkook 
Published: February 2020

Abstract2D materials, specifically MoS2 semiconductors, have received tremendous attention for photo‐sensing applications due to their tunable bandgap and low noise levels. A unique photodetector using multilayer MoS2 as the semiconductor channel, in which the gate electrode of the device is permanently connected to the grounded source electrode to introduce rectification, is reported. The proposed grounded‐gate photodiode exhibits high photoresponsivity of 1.031 A W−1, excellent photodetectivity (>6 × 1010 jones), and highly stable rise/fall time response (100–200 ms) under illumination of visible light (at the wavelengths of 405, 532, and 638 nm). Numerical device simulations using quantum transport methods and photoconductive effects are used to explain the device operation. It is also suggested that the gate metal work function can be carefully chosen to increase the sensitivity of the grounded‐gate photodetector by suppressing the dark current. The grounded‐gate device proposed, owing to the properties of rectifying behavior, low contact resistance, consistent photoresponsivity, and linear sensitivity, provides a new platform for next‐generation applications in the field of electronics and optoelectronics.
Biochar improved sorghum germination and seedling growth under salinity stress
Authors: Ibrahim Muhi Eldeen Hussien , Ali Adam Yousif Adam , Elsiddig Aboagla Mohammed Ibrahim , Zhou Guisheng , Nimir Nimir Eltyb Ahmed , Ahmad Irshad , Suliman Mohamed Suliman Eltyeb , Elradi Safiya Babiker Mustafa , Salih Ebtehal Gabralla Ibrahim 
Published: February 2020

AbstractSalinity is a growing problem worldwide, and techniques are needed to mitigate this problem. This study was conducted to determine if biochar (BC) can alleviate the adverse impacts of salinity stress on sorghum (Sorghum bicolor L.) seedling growth. Sorghum variety Kambal was sown in salinized soils at levels of 1.2, 3.1, and 7.3 dS m−1. The saline soils were treated with four BC rates of 0, 2, 4, and 8% (w/w). The test was a factorial design arranged as a completely randomized design with three replications. Seedling emergence percentage; root and shoot length; root and shoot dry weight; relative water content (RWC); and the activity of catalase (CAT), peroxidase (POD), and superoxide dismutase (SOD) were affected by the interaction between salinity and BC. At the 7.3 dS m−1 salinity level, 2% BC increased seedling emergence percentage by 25.0% (P = .012). At the 7.3 dS m−1 salinity level, 4% BC level increased root and shoot length (P = .009) and RWC by 46.0, 28.0, and 19.8% respectively. At the 7.3 dS m−1 salinity level, 8% biochar decreased CAT by 50.6%. At the high salinity level, 4% BC decreased POD and SOD by 24.9 and 23.4%, respectively. Biochar amendment proved to be more useful to alleviate the effects of salinity on the seedling growth stage. These findings suggest that using BC in suitable amounts could mitigate the adverse effects of salinity, but excess BC application may have negative influences on seedling growth.
Duodenum metastatic adenocarcinoma of lung origin: A case report
Authors: Tsai Tsung‐Jung , Chen Tsung‐Hsien , Tung Chun‐Liang 
Published: February 2020

AbstractDuodenal metastases from lung adenocarcinoma are extremely uncommon, and rarely produce symptoms. We report a case of duodenal metastasis from primary lung adenocarcinoma presented with history of gastroesophageal reflux disease, superficial gastritis, and chemotherapy‐related grade I fatigue. Tumor cells showed immunopositivity for cytokeratin‐7 (CK7), thyroid transcription factor 1, and immunonegativity for CK20, CDX2, and synaptophysin, supporting the diagnosis of metastatic adenocarcinoma of the lung origin.
Congenital heart disease in school children in Lagos, Nigeria: Prevalence and the diagnostic gap
Authors: Ekure Ekanem N. , Sokunbi Ogochukwu , Kalu Nnenna , Olusegun‐Joseph Akinsanya , Kushimo Oyewole , Amadi Casmir , Hassan Olayinka , Ikebudu Desmond , Onyia Sophia , Onwudiwe Chinonso , Nwankwo Victor , Akinwunmi Remi , Awusa Fukpode , Akere Zainab , Dele‐Salawu Olaolu , Ajayi Elizabeth , Ale Olagoke , Muoneke Dorothy , Muenke Maximillian , Kruszka Paul , Beaton Andrea , Sable Craig , Adeyemo Adebowale 
Published: February 2020

AbstractCongenital heart disease (CHD) in low‐and‐middle income countries (LMIC) is often characterized by late presentation resulting from inadequate screening and healthcare access in these regions. Accurate estimates of the burden of CHD among school children are often lacking. The objective of this study was to determine the prevalence and distribution of CHD among school children in two communities (urban and semi‐urban) in south western Nigeria. Using clinical assessment and portable echocardiography, 4107 school children aged 5 years to 16 years in Lagos, Nigeria, were selected using a multistage sampling procedure and screened for CHD. Diagnosis of CHD was made after echocardiography. Children identified with CHD were referred to a tertiary hospital for appropriate cardiac care. The 4,107 children screened had a mean age of 11.3 ± 2.7 years and 53.7% were females. Twenty seven children had echocardiography‐confirmed CHD, representing a prevalence of CHD among school children in Lagos, Nigeria of 6.6 per 1000 children. Acyanotic CHD constituted 96.3% of detected cases. Two children diagnosed with CHD (Tetralogy of Fallot and severe pulmonary valve stenosis respectively) had successful intervention. The prevalence of previously undiagnosed CHD among school children in Lagos Nigeria is substantial and highlights gaps in the health care system and school health programs. Echocardiographic screening of school children provides an opportunity for missed early diagnosis and treatment of CHD and reduces the prevalence of first‐diagnosed CHD in adulthood. Therefore, focused clinical examination of school children followed by echocardiography is a strategy that could bridge this diagnostic and treatment gap in CHD.
Impact of deprescribing AChEIs on aggressive behaviors and antipsychotic prescribing
Authors: Niznik Joshua D. , Zhao Xinhua , He Meiqi , Aspinall Sherrie L. , Hanlon Joseph T. , Nace David , Thorpe Joshua M. , Thorpe Carolyn T. 
Published: February 2020

AbstractIntroductionWe evaluated the impact of deprescribing acetylcholinesterase inhibitors (AChEIs) on aggressive behaviors and incident antipsychotic use in nursing home (NH) residents with severe dementia.MethodsWe conducted a retrospective study of Medicare claims, Part D, Minimum Data Set for NH residents aged 65+ with severe dementia receiving AChEIs in 2016. Aggressive behaviors were measured using the aggressive behavior scale (ABS; n = 30,788). Incident antipsychotic prescriptions were evaluated among antipsychotic non‐users (n = 25,188). Marginal structural models and inverse probability of treatment weights were used to evaluate associations of AChEI deprescribing and outcomes.ResultsThe severity of aggressive behaviors was low at baseline (mean ABS = 0.5) and was not associated with deprescribing AChEIs (0.002 increase in ABS, P = .90). Incident antipsychotic prescribing occurred in 5.1% of residents and was less likely with AChEI deprescribing (adjusted odds ratio = 0.52 [0.40–0.68], P <.001]).DiscussionDeprescribing AChEIs was not associated with a worsening of aggressive behaviors or incident antipsychotic prescriptions.
Conservation status of two endangered freshwater mussel species in Bavaria, Germany: Habitat quality, threats, and implications for conservation management
Authors: Stoeckl Katharina , Denic Marco , Geist Juergen 
Published: February 2020

Abstract

The freshwater pearl mussel (Margaritifera margaritifera) and the thick‐shelled river mussel (Unio crassus) are relatively widespread across Europe, but are strongly declining and are now protected by the European Habitats Directive. In the course of this study, 20 pearl mussel and 14 thick‐shelled river mussel streams in Bavaria, Germany, were investigated.
The mussel populations were mapped to determine population size and age structure. For the assessment of habitat quality, host fish abundance and physicochemical parameters were investigated, e.g. substratum quality, water chemistry, redox potential, and turbidity. Furthermore, potential risks for the populations such as predation or river maintenance were also recorded and assessed.
The average population size and recruitment rates of M. margaritifera populations were lower than in U. crassus populations, with 3517 (2.2% juveniles) compared with 5566 (41.4% juveniles) individuals, respectively. On average, 22.3% of particles were smaller than 0.85 mm in diameter at M. margaritifera sites, whereas the mean proportion of fine particles at U. crassus sites was twice as high, at 41.3%. Other parameters such as redox potential or electric conductivity also indicated more favourable habitat conditions in M. margaritifera streams. Unio crassus seems to be less vulnerable to adverse substratum texture and increased nutrient levels than M. margaritifera.
The main threats for U. crassus were physical habitat destruction, predation by muskrat, or a lack of host fish, whereas M. margaritifera mainly suffered from siltation leading to a lack of oxygen supply to the interstitial zone, affecting recruitment. Consequently, conservation strategies need to be species‐specific and address stream‐specific reasons for decline. As a basis, accurate and comparable monitoring data are necessary, which implies the standardization of monitoring protocols.
Sex difference in the progression of manic symptoms during acute hospitalization: A prospective pilot study
Authors: Abulseoud Osama A. , Şenormancı Güliz , Şenormancı Ömer , Güçlü Oya , Schleyer Brooke , Camsari Ulas 
Published: February 2020

AbstractObjectivesAcute mania is a serious medical condition that impacts men and women equally. Longtime presentation of manic symptoms is sex‐dependent; however, little is known about acute symptoms of mania. The objective of this study is to track and compare acute manic symptoms for sex differences during inpatient hospitalization.MethodsAll patients with bipolar mania admitted to a large university hospital between January and October 2017 were invited to participate in this longitudinal naturalistic follow‐up study. Manic (YMRS), depressive (MADRS), and psychotic (PAS) symptoms were tracked daily from admission to discharge.ResultsThe total YMRS scores decreased significantly overtime (p < .0001) in both male (n = 34) and female (n = 23) patients (p = .7). However, male patients scored significantly higher in sexual interest (p = .01), disruptive and aggressive behavior (p = .01), and appearance (p < .001) while females had better insight into their illness (p = .01). Males and females received similar doses of lithium (p = .1), but males received significantly higher doses of valproic acid (VPA) in comparison with females (p = .003). However, plasma lithium and VPA concentrations at discharge were not significantly different between sexes.ConclusionOur results show sex differences in the progression of certain domains of manic symptoms in a cohort of 23 female and 34 male patients admitted to a large academic center in Turkey. Males, in this sample, exhibited more sexual interest, disruptive and aggressive behaviors, better grooming, and less insight compared to females. While these results are concordant with our preclinical findings and with anecdotal clinical observations, replication in larger samples is needed.
Isoniazid‐induced pellagra in a patient with Crohn's disease
Authors: Kchir Hela , Yacoub Haythem , Hassine Hajer , Maamouri Nadia 
Published: February 2020

AbstractIsoniazid preventive therapy in malnourished patients with Crohn's disease has a potential of inducing pellagra but still a very rare situation. No cases of isoniazid‐induced pellagra in patients with Crohn's disease were reported in the literature. Pellagra can be easily treated if timely diagnosed.
New sensor fault detection and isolation strategy–based interval‐valued data
Authors: Harkat Mohamed Faouzi , Mansouri Majdi , Abodayeh Kamaleldin , Nounou Mohamed , Nounou Hazem 
Published: February 2020

AbstractIn this paper, a new data‐driven sensor fault detection and isolation (FDI) technique for interval‐valued data is developed. The developed approach merges the benefits of generalized likelihood ratio (GLR) with interval‐valued data and principal component analysis (PCA). This paper has three main contributions. The first contribution is to develop a criterion based on the variance of interval‐valued reconstruction error to select the number of principal components to be kept in the PCA model. Secondly, interval‐valued residuals are generated, and a new fault detection chart‐based GLR is developed. Lastly, an enhanced interval reconstruction approach for fault isolation is developed. The proposed strategy is applied for distillation column process monitoring and air quality monitoring network.