bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of sarcopenia on short- and long-term outcomes in patients with gastric neuroendocrine neoplasms after radical gastrectomy: Results from a large, two-institution series.
Authors: Wang Jia-bin , Xue Zhen , Lu Jun , He Qing-liang , Zheng Zhi-fang , Xu Bin-bin , Xie Jian-wei , Li Ping , Xu Yu , Lin Jian-xian , Chen Qi-yue , Cao Long-long , Lin Mi , Tu Ru-hong , Huang Ze-ning , Lin Ju-li , Huang Chang-ming , Zheng Chao-Hui 
Published: September 2020

Abstract
Background: The relationship between sarcopenia and the prognoses of patients with gastric neuroendocrine neoplasms (g-NENs) is unclear. This study was designed to explore the effects of sarcopenia on short-term and long-term outcomes of patients with g-NENs after radical gastrectomy.Methods: This study retrospectively collected data from 138 patients with g-NENs after radical gastrectomy. The skeletal muscle index (SMI) diagnostic threshold for sarcopenia was determined using X-tile software. Cox regression analyses were performed to determine the independent risk factors for 3-year overall survival (OS) and 3-year recurrence-free survival (RFS).Results: In this study, 59 patients (42.8%) were diagnosed with sarcopenia. Among patients in the sarcopenia group and nonsarcopenia group, the incidences of total postoperative complications were 33.9% and 30.4%, incidences of serious postoperative complications were 0% and 3.7%, incidences of postoperative surgical complications were 13.6% and 15.2%, and incidences of postoperative systemic complications were 20.3% and 15.2%, respectively (all p>0.05). The 3-year OS and RFS rates were significantly worse in the sarcopenia group than in the nonsarcopenia group (OS: 42.37% vs 65.82%, p=0.004; RFS: 52.54% vs 68.35%, p=0.036). The multivariate analysis revealed a relation between sarcopenia and the long-term prognoses of patients with g-NENs. A stratified analysis based on the pathological type revealed that the Kaplan-Meier curve was only significantly different in patients with gastric mixed adenoneuroendocrine carcinoma (gMANEC) (OS: 40.00% vs 71.79%, p=0.007; RFS: 51.43% vs 74.36%, p=0.026); furthermore, the multivariate analysis identified sarcopenia as an independent risk factor for patients with gMANEC (p<0.05).Conclusions: Sarcopenia is not related to the short-term prognoses of patients with g-NENs. Sarcopenia is an independent risk factor for patients with gMANEC after radical surgery.
Carfilzomib Induced Cardiotoxicity in a Multiple Myeloma Patient
Authors: Toro Arnold Mendez , Diaz-Brochero Candida , Acosta-Gutierrez Estivalis 
Published: September 2020

Abstract
Proteasome inhibitors such as carfilzomib are indicated in multiple myeloma patients showing relapse and/or refractoriness of clonal activity. However, this therapy has been associated with a significant incidence of cardiotoxicity, especially in patients with known cardiovascular risk factors. Here we report a case of a 60-year-old woman with multiple myeloma, who developed severe congestive heart failure with positive myocardial injury biomarkers together with impaired LVEF and GLS, after treatment with carfilzomib. Therefore, chemotherapeutic drug was discontinued and neurohormonal blocking and diuretic therapy was started resulting in amelioration of symptoms, without changes in LVEF but with significant GLS improvement. Although high-grade cardiotoxicity is relatively rare in patients with non previous cardiac risk factors, it was a predictable side effect of carfilzomib use. Recognition of this syndrome is critical to instauration of appropriate therapy and prevention of morbimortality
Ceramic bricks containing Ni ions from contaminated biomass used as an adsorbent
Authors: Simón Daiana , Quaranta Nancy , Gass Sebastián , Procaccini Raúl , Cristóbal Adrián 
Published: September 2020

Abstract
This article shows how pine sawdust residues can be used to adsorb nickel ions from synthetic solutions and then to produce porous bricks for civil construction using a mixture of natural clay and biomass containing the adsorbed metals. The adsorption tests were performed by mixing NiCl2 solutions with pine sawdust during a fixed stirring period of 24 h. The set was filtered and the filtrate was analysed. Highest efficiency adsorbate/adsorbent ratio was 1 mol L-1 of NiCl2 solution and 20 g L-1 of pine sawdust. This was the contaminated biomass sample used in the manufacture of the bricks. This paper analyses the properties of the bricks achieved and compares them with bricks without added biomass, porous bricks containing zinc and commercial bricks. The obtained values ​​of bulk density (apD), apparent specific weight (apsW), apparent porosity (apP), water absorption (H2OAbs), apparent volume (apV), weight loss on ignition (LOI), compressive strength (σstr), flexural modulus of rupture (MOR) and efficiency retention of metal in the brick (RE), demonstrate that the ceramic pieces obtained are optimal for construction.
Comparative study on lesions of reproductive disorders of cows and female dromedary camels slaughtered at Addis Ababa, Adama and Akaki abbatoirs with bacterial isolation and characterization
Authors: Mandefro Aynalem , Ayana Tilaye Demissie , Hunderra Gemechu Chala , Gebrezihar Tadesse Gidey , Boru Bulto Giro , Desta Natnael Teshager 
Published: September 2020

Abstract
Background: Reproduction is a basic prerequisite to efficient livestock production. Reproductive performance depends upon the normal structure and function of genital organs. Methods: A cross-sectional study was conducted from November 2016 to May 2017 to identify and compare the frequency of pathological lesions in the reproductive tract and to isolate bacteria associated to uterine lesions in female dromedary camels and cows slaughtered at Akaki camel slaughter house and Addis Ababa and Adama municipal abattoirs. Purposive sampling technique was used to collect 280 reproductive tracts from cows and female dromedary camels. Following gross inspection at abattoirs, tissue samples with lesion were collected for histopathological and bacteriological investigation. Result: Various pathological lesions with different degrees of severity were observed in 48 (34.2 %) and 51 (36.4%) of dromedary camels and cows, respectively. Uterine lesions were the most prevalent (21.4%) lesions observed in dromedary camels followed by ovarian lesions (7.14%); while in cows, ovarian lesions were the major prevalent (16.4%) lesions followed by uterine lesion (14.2%). The result showed that there were 56 bacteria isolated from cows uterine lesion with Staphylococcus species (28.5%), Streptococci species (19.6%), Coynebacterium species (8.9%), Escherichia coli (26.78%), Salmonella species (10.7%) and Klebsiella species (5.35%) being the prominent isolates; while in camels, there were 45 bacteria isolated with Escherichia coli (35.5%), Staphylococcus species (26.6%), Streptococcus species (13.3%), Pseudomonas species (6.6 %), Proteus species (4.4%), Salmonella species (8.8%) and Klebsiella species (4.4%) being the most frequently isolated. The result showed that the major isolates were similar with slightly higher in cows. Histopathologically, endometrial glands degeneration, sloughing of epithelium, peri-glandular cuffing and infiltrations of inflammatory cell were some of characteristic changes observed in uterus. Conclusions: Pathological lesions in reproductive organs in female dromedary camels and cows showed great prevalence, with similarity in bacterial isolates between the two species. The role of each reproductive lesions and bacterial isolates incriminated as causes of reproductive failures in this livestock species needs further investigation.
Semi-embedded Valve Anastomosis A new anti-reflux anastomotic method after proximal gastrectomy for adenocarcinoma of the oesophagogastric junction
Authors: Wang Baohua , Wu Yupeng , Wang Haijun , Zhang Haiqiang , Wang Liting , Zhang Zhanxue 
Published: September 2020

Abstract
Background

There is a high probability of gastroesophageal reflux after laparoscopic proximal gastrectomy for Siewert Ⅱ AEG. Various anti-reflux anastomotic methods are emerging in clinical practice; however, none of them have been widely accepted. We have innovated a new type of anti-reflux anastomotic method, named semi-embedded valve anastomosis. The aim of this study was to explore the feasibility and anti-reflux effect of the new anastomotic method.

Methods

The clinical data of 28 patients with Siewert II AEG who were treated by semi-embedded valve anastomosis were collected. The key point of the operation is to reconstruct a simulated valve and form an anti-reflux barrier similar to the physiological mechanism. The GerdQ gastroesophageal reflux questionnaire and classification of gastroesophageal reflux under electron microscopy were used to evaluate gastroesophageal reflux after the operation.

Results

The mean operative duration was 164.3±19.0 min, the median intraoperative haemorrhage volume was 65 ml, the average number of lymph nodes dissected was 23±2.6, the time for valve construction was 15.8±3.2 min, the time for anastomotic reconstruction was 35.4±4.8 min, the median time to first flatus was 3 d, and the median hospitalization duration was 12 d. There was one case of postoperative anastomotic stenosis. The GerdQ score [median (range)] was as follows: 2 (0-6), preoperation; 0 (0-8), 1 month postoperation; 2 (0-12), 3 months postoperation; and 3 (0-12), 6 months postoperation. The Wilcoxon signed-rank sum test was carried out at different times after the operation and the day before the operation, and the differences were not significant (P<0.05). There was one case of grade B gastroesophageal reflux according to the LA classification system among the gastrofibroscopic re-examination reports of 28 cases.

Conclusion

Semi-embedded valve anastomosis is safe and feasible after proximal gastrectomy for Siewert II AEG and has good anti-reflux effects.
Little Akaki River Sediment Enrichment with Heavy Metals, Pollution Load and Potential Ecological Risks in Downstream, Central Ethiopia
Authors: Mekuria Deshu Mamo , Kassegne Alemnew Berhanu Berhanu , Asfaw Seyoum Leta Leta 
Published: September 2020

Abstract
Background: The Addis Ababa City’s river ecosystem is under extreme pressure as a result of inappropriate practices of dumping domestic and industrial wastes; thus, threatening its ability to maintain basic ecological, social and economic functions. Little Akaki River which drains through Addis Ababa City receives inorganic and organic pollutants from various anthropogenic sources. Most of inorganic pollutants such as toxic heavy metals relased into the river are eventually adsorbed and settled in the sediment. The objective of this study was to evaluate the enrichment levels, pollution load and ecological risks of selected heavy metals ( Zn, Cr, Cd and Pb) using various indices .Results: The mean concentrations of heavy metals in Little Akaki River sediment were: Zn (78.96±0.021 - 235.2 ±0.001mg / kg); Cr (2.19±0.014 - 440.8±0.003 mg / kg); Cd (2.09±0.001-4.16 ±0.0001mg / kg) and Pb (30.92±0.018 -596.4±0.066 mg / kg). Enrichment factor values indicated that sediments were moderate to significant enrichment with Zn and Cr; moderate to very high enrichment with Pb, and very high enrichment in all sampled sites with Cd. Geo-accumulation index and contamination factor values indicated that the sediments were moderate to very high contamination with toxic Cd and Pb. The decreasing order of pollution load index (PLI) in downstream was: (S9) > (S4) > (S8) > (S3)> (S6) > (S10) > (S5) > (S2)> (S7) > (S1). PLI and hierarchal cluster analysis revealed that highest pollution load occurred in the lower course of the river (S9) which may be due to metals inputs from anthropogenic sources; hence, its quality was deteriorated showing that the site is polluted. The ecological risk (RI =350.62) suggested that the contaminated Little Akaki River (LAR) sediment can pose considerable ecological risks of pollution.Conclusions: The concentrations of Zn, Cr, Cd and Pb in Little Akaki River sediment surpassed eco-toxicological guideline limits of USEPA (threshold effect concentration) and CCME (Interim Sediment Quality Guidelines). Thus, the contaminated sediments can occasionally pose adverse biological effects on sediment dwelling organisms. Thus, measures must be taken to regulate discharge of untreated wastes into river and surrounding environment.
Transcriptome response comparison between vector and non-vector aphids after feeding on virus-infected wheat plants
Authors: Li Dandan , Zhang Chi , Tong Zeqian , Su Dan , Zhang Gaisheng , Zhang Shize , Zhao Huiyan , Hu Zuqing 
Published: September 2020

Abstract
Background

Plant viruses maintain intricate interactions with their vector and non-vector insects and can impact the fitness of insects. However, the details of their molecular and cellular mechanisms have not been studied well. We compared the transcriptome-level responses in vector and non-vector aphids ( Schizaphis graminum and Rhopalosiphum padi ) after feeding on wheat plants with viral infections ( Barley Yellow Dwarf Virus (BYDV)/ Wheat dwarf virus (WDV)). We conducted differentially expressed gene (DEG) annotation analyses and observed DEGs related to immune pathway, growth, development, and reproduction. And we conducted cloning and bioinformatic analyses of the key DEG involved in immune.

Results

For all differentially expressed gene analyses, the numbers of DEGs related to immune, growth, development, reproduction and cuticle were higher in vector aphids than in non-vector aphids. STAT5B (signal transducer and activator of transcription 5B), which is involved in the JAK-STAT pathway, was upregulated in R. padi exposed to WDV. The cloning and bioinformatic results indicated that the RpSTAT5B sequence contains a 2082 bp ORF encoding 693 amino acids. The protein molecular weight is 79.1 kD and pI is 8.13. Analysis indicated that RpSTAT5B is a non-transmembrane protein and a non-secreted protein. Homology and evolutionary analysis indicated that RpSTAT5B was closely related to Rhopalosiphum maidis.

Conclusions

Unigene expression analysis showed that the total number of differentially expressed genes (DEGs) in the vector aphids was larger than that in the non-vector aphids. Functional enrichment analysis showed that the DEGs related to immunity, growth and reproduction in vector aphids were larger than those in non-vector aphids, and the differentially expressed genes related to immune were up-regulated. This study provides a basis for the evaluation of the response mechanisms of vector/non-vector insects to plant viruses.
Life Satisfaction among a Clinical Eating Disorder Population
Authors: Claydon Elizabeth , DeFazio Caterina , Lilly Christa L. , Zullig Keith J. 
Published: September 2020

Abstract
Background: The primary objective was to understand life satisfaction (LS) of patients with eating disorders (EDs) in relation to eating pathology severity, personal/familial ED history, and key demographic and anthropometric variables. Methods: Participants (N=60) completed the Satisfaction with Life Scale (SWLS), the Eating Pathology Severity Index (EPSI), and demographic questionnaires. Bivariate associations via correlations and multiple linear regression models were used to explore these relationships. Results: The SWLS mean score was 3.7 out of 7, suggesting it is below the population-based norm. LS was positively statistically significantly associated with private insurance, past ED, EPSI muscle building, EPSI restricted eating, and EPSI negative attitudes. When included in multiple linear regression, the model explained 33% of the variability of LS [F (7, 56) = 3.4, p = 0.0054, R2 = 0.33]. EPSI muscle building remained the strongest predictor (β = 0.13, p = 0.04). Conclusions: Based on the data, individuals who have/have had EDs scored lower on the SWLS than the general population. Individuals scoring within this range typically experience significant issues in several areas of life or a substantial issue in one area.
Risk factors affecting the 1-year outcomes of minor ischemic stroke: results from Xi’an stroke registry study of China[1]
Authors: Liu Zhongzhong , Lin Wenjuan , Lu Qingli , Wang Jing , Liu Pei , Lin Xuemei , Wang Fang , Shi Yaling , Wang Qing , Liu Guozheng , Wu Songdi 
Published: September 2020

Abstract
Background: The incidences of stroke recurrence, disability, and all-cause death of patients with minor ischemic stroke (MIS) remain problematic. The aim of the present was to identify risk factors associated with adverse outcomes at 1-year after MIS in the Xi’an region of China. Methods: The cohort of this prospective cohort study included MIS patients aged 18–97 years with a National Institutes of Health Stroke Scale (NIHSS) score of ≤ 3 who were treated in any of four hospitals in Xi’an region of China between January and December 2015. The 1-year percentage of stroke recurrence, disability, and all-cause death were evaluated. Multivariate logistic regression analysis was performed to assess the association between the identified risk factors and clinical outcomes. Results: Among the 1,121 patients included for analysis, the percentage of stroke recurrence, disability, and all-cause death at 1 year after MIS were 3.4% (38/1121), 9.3% (104/1121), and 3.3% (37/1121), respectively. Multivariate logistic regression analysis identified age, current smoking, and pneumonia as independent risk factors for stroke recurrence. Age, pneumonia, and alkaline phosphatase were independent risk factors for all-cause death. Independent risk factors for disability were age, pneumonia, NIHSS score on admission, and leukocyte count. Conclusions: The 1-year outcomes of MIS is not optimistic in the Xi’an region of China, especially high percentage of disability. In this study, we found the risk factors affecting 1-year stroke recurrence, disability and, all-cause death which need further verification in the subsequent studies.
Application of Ex Vivo Liver Resection Followed by the Autotransplantation Technique in Radical Resection of Gastric Cancer Liver Metastases: A Case Report
Authors: Wang Hong , Zhang Chengcheng , Ou Yanjiao , Zhang Leida 
Published: September 2020

Abstract
Background Radical resection of gastric cancer liver metastases can increase the 5-year survival rate of GCLM patients. However, patients may lose the theoretical feasibility of surgery due to the critical location of liver metastasis in some cases. Case presentation A 29-year-old female had a chief complaint of chronic abdominal pain for one year. Abdominal CT and MRI examinations suggested a mass of unknown pathological nature located between the first and second hila and the margin of the lower segment of the right lobe of the liver. The anterior wall of the gastric antrum was unevenly thickened. The diagnosis of (gastric antrum) intramucosal well-differentiated adenocarcinoma was histopathologically confirmed by puncture biopsy with gastroscopy guidance. The pathological properties of the liver mass remained unclear before surgery. She underwent radical resection (excision of both gastric tumors and ELRA simultaneously）followed by XELOX adjuvant chemotherapy. Without serious postoperative complications, the patient was successfully discharged on the 20th day after the operation. Pathological examination of the excised specimen indicated that gastrectomy with D2 lymph node dissection for primary gastric tumors and R0 resection for liver metastases were achieved. The resected mass was confirmed to be poorly differentiated gastric carcinoma (hepatoid adenocarcinoma with neuroendocrine differentiation) with liver metastases in segments 6 and 8. A Follow-up review that began one month after surgery showed no recurrence or metastasis within the liver. The mother of three children miraculously lived a happy life and went back to work as normal. Conclusions: Application of ELRA in radical resection for GCLM can help selected patients with intrahepatic metastases located in complex sites obtain a favorable clinical outcome.
Baseline total metabolic tumor volume combined with international peripheral T-cell lymphoma project may improve prognostic stratification for patients with peripheral T-cell lymphoma (PTCL)
Authors: Jiang Chong , Teng Yue , Chen Jieyu , Wang Zhen , Zhou Zhengyang , Ding Chongyang , Xu Jingyan 
Published: September 2020

Abstract
Purpose: The aim of this study was to explore the prognostic value of total metabolic tumor volume (TMTV) at baseline 18F-FDG PET/CT in patients diagnosed with peripheral T-cell lymphoma (PTCL).Materials and methods: Eighty-four newly diagnosed PTCL patients who underwent baseline 18F-FDG PET/CT prior to treatment between March 2009 and January 2019 were enrolled in this retrospective study. The FDG-avid lesions in each patient were segmented using semiautomated software to calculate the maximum standardized uptake value (SUVmax), total metabolic tumor volume (TMTV), and total lesion glycolysis (TLG) values using the boundaries of voxels presenting with the 41% SUVmax threshold method. Progression-free survival (PFS) and overall survival (OS) were used as end points to evaluate patient prognosis. The log-rank test and Cox regression analyses were used to evaluate PFS and OS.Results: ROC curve analysis indicated an ideal TMTV cut-off value of 228.8 cm3. During the 4-131 month (29.2±28.5 months) follow-up period, high TMTV was significantly associated with worse PFS and OS. TMTV and the international peripheral T-cell lymphoma project score (IPTCLP) were independent predictors of PFS and OS with multivariate analysis. The combination of TMTV and the IPTCLP may provide significantly better risk substratification in PFS and OS of PTCL patients.Conclusions: Both TMTV and IPTCLP are independent predictors of PTCL patient survival outcomes. Moreover, the combination of TMTV and IPTCLP improved patient risk stratification and may contribute to personalized therapeutic regimens.
WITHDRAWN: An integrated process of methanol coagulation and side stream membrane bioreactor for treatment of rice gruel wastewater
Authors: Nazia Shaik , Mishra Karishma , Jegatheesan Veeriah , Bhargava Suresh K , Sundergopal Sridhar 
Published: September 2020

Abstract
Significant demand for water supply was to expect forthcoming decades. Production of reusable water from industrial and domestic wastewater is a feasible, cost-effective, and significant positive benefit to the environment. In the present study, the domestic rice gruel wastewater (RGW) treated with aqueous methanol coagulation integrated aerobic membrane bioreactor (AMBR). Hydrophilized spiral wound 5 kDa ultrafiltration membrane (HF – UF) used in the bioreactor for the effective removal of pollutants from RGW. Furthermore, the RGW pretreated with various coagulants such as methanol, ethanol, and HCl. The obtained pretreated RGW subjected to the HF-UF 5 kDa side stream AMBR for reusable water production. The experiments conducted to determine the turbidity, conductivity, total dissolved solids (TDS), and chemical oxygen demand (COD) found to be 96 %, 91 %, 91 %, and 94.6 %. The overall process was feasible, compact, environmentally free, cost-effective, eco-friendly.