bluuebunny/crossref_metadata_2025_split huggingface dataset:
Open and Distance Learning Programs for Nursing and Midwifery Education in East Africa: Protocol for a Scoping Review
Authors: Isangula Kahabi , Edwards Grace , Mwansisya Tumbwene , Mbekenga Columba , Pallangyo Eunice , Sarki Ahmed , Ndirangu-Mugo Eunice 
Published: November 2020

Background
In the face of growing modernity and the coronavirus disease 2019 (COVID-19) pandemic, open and distance learning (ODL) is considered to play an important role in increasing access to education worldwide. There is a robust evidence base demonstrating its cost effectiveness in comparison with conventional class-based teaching; however, the transition to this new paradigm of learning for nursing and midwifery courses has been difficult in low-income countries. While there are notable efforts to increase internet and education access to health care professionals, not much is known about ODL for nurses and midwives in East African countries.

Objective
The objective of this scoping review is to understand whether ODL programs for nursing and midwifery education exist, the drivers of their adoption, their implementation, the topics/courses covered, their acceptability, and their impacts in East African countries.

Methods
The scoping review methodology employs the framework developed by Arksey and O’Malley. Using an exploratory approach, a two-stage screening process consisting of a title and abstract scan and a full-text review will be used to determine the eligibility of articles. To be included, articles must report on an existing ODL initiative for nurses and midwives in Uganda, Tanzania, and Kenya. All articles will be independently assessed for eligibility by pairs of reviewers, and all eligible articles will be abstracted and charted in duplicate using a standardized form.

Results
Details of ODL for nursing and midwifery education initiatives and study outcomes will be summarized in a table. The extracted data will undergo exploratory descriptive analysis, and the results will be classified into learner and clinical outcomes.

Conclusions
Evidence on ODL for nursing and midwifery education will inform the ongoing development and restructuring of health care professional education in East Africa amidst the COVID-19 pandemic.

International Registered Report Identifier (IRRID)
PRR1-10.2196/17765
Valproic Acid as an Adjuvant Treatment for Generalized Convulsive Status Epilepticus in Adults Admitted to Intensive Care Units: Protocol for a Double-Blind, Multicenter Randomized Controlled Trial
Authors: Sharshar Tarek , Ben Hadj Salem Omar , Porcher Raphaël , Grimaldi-Bensouda Lamiae , Heming Nicholas , Clair Bernard , Azabou Eric , Mazeraud Aurélien , Rohaut Benjamin , Outin Hervé 
Published: November 2020

Background
Generalized convulsive status epilepticus (GCSE) is a frequent medical emergency. GCSE treatment focuses on the administration of benzodiazepines followed by a second-line antiepileptic drug (AED). Despite this stepwise strategy, GCSE is not controlled in one-quarter of patients and is associated with protracted hospitalization, high mortality, and long-term disability. Valproic acid (VPA) is an AED with good tolerability and neuroprotective properties.

Objective
This study aims to demonstrate that administration of VPA as an adjuvant for first- and second-line treatment in GCSE can improve outcomes.

Methods
A multicenter, double-blind, randomized controlled trial was conducted, comparing VPA with a placebo in adults admitted to intensive care units (ICUs) for GCSE in France. GCSE was diagnosed by specifically trained ICU physicians according to standard criteria. All patients received standard of care, including a benzodiazepine and a second-line AED (not VPA), at the discretion of the treating medical team. In the intervention arm, VPA was administered intravenously at a loading dose of 30 mg/kg over 15 minutes, followed by a continuous infusion of 1 mg/kg/hour over the next 12 hours. In the placebo group, an identical intravenous administration of 0.9% saline was used. The primary outcome was the proportion of patients discharged alive from the hospital by day 15. Secondary outcomes were frequency of refractory and super refractory GCSE, ICU-related morbidity, adverse events related to VPA, and cognitive dysfunction at 3 months. Statistical analyses will be performed according to the intent-to-treat principle.

Results
The first patient was randomized on February 18, 2013, and the last patient was randomized on July 7, 2018. Of 248 planned patients, 98.7% (245/248) were enrolled across 20 ICUs. At present, data management is still ongoing, and all parties involved in the trial remain blinded.

Conclusions
The Valproic Acid as an Adjuvant Treatment for Generalized Convulsive Status Epilepticus (VALSE) trial will evaluate whether the use of VPA as an adjuvant for first- and second-line treatment in GCSE improves outcomes.

Trial Registration
ClinicalTrials.gov NCT01791868; https://clinicaltrials.gov/ct2/show/NCT01791868.

International Registered Report Identifier (IRRID)
DERR1-10.2196/22511
Web-Based Interventions to Promote Healthy Lifestyles for Older Adults: Protocol for a Scoping Review
Authors: Lavoie Audrey , Dubé Véronique 
Published: November 2020

Background
With the aging of the population and rising rates of chronic diseases, older adults need support if they are to adopt healthy lifestyles. Web-based interventions should be considered for this purpose, since they are easily accessed and can foster healthy lifestyles among older adults. However, the literature on such interventions discusses a variety of components and effects and provides only 2 syntheses of knowledge on web-based interventions with older adults. These studies focus on populations aged 50 years and older, whereas the components and effects of interventions for a population of older adults (ie, 65 years and older) may differ. In addition, these 2 syntheses examined only quantitative studies, although other types of studies (ie, qualitative) are available and could help advance knowledge in this field. A scoping review is therefore relevant in order to explore the extent of the literature on this subject.

Objective
The purpose of the study described by this protocol is to explore the extent of the literature (experimental, quasi-experimental, qualitative, systematic reviews, and grey literature) on the components and effects of web-based interventions as a way to promote healthy lifestyles among older adults.

Methods
The databases MEDLINE, CINAHL, PsycInfo, Web of Science, Cochrane Database of Systematic Review and Joanna Briggs Library will be searched, in addition to the grey literature using Google Scholar and OpenGrey. Studies will be selected for the review by 2 researchers, working independently. The data will be synthesized based on the conceptualization of web-based interventions (ie, behavior change techniques, dispensation modes, and theories). A thematic analysis will be performed to summarize the components of the interventions studied.

Results
The database search will begin in August 2020 and be completed in October 2020.

Conclusions
This scoping review should highlight web-based interventions designed to promote healthy lifestyles, as well as their components and effects, among people aged 65 years and older. These results could provide important guidance for intervention developers and designers in identifying the components of web-based interventions relevant to older adults and lead to further studies on this topic.

International Registered Report Identifier (IRRID)
PRR1-10.2196/23207
Emotional Bias Modification for Individuals With Attention Deficit Hyperactivity Disorder: Protocol for a Co-Design Study
Authors: Zhang Melvyn , Vallabhajosyula Ranganath , Fung Daniel 
Published: November 2020

Background
Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder with a worldwide prevalence rate of 5%. Individuals with ADHD often tend to have difficulties with emotional regulation. The advances in experimental psychology have led to the discovery of emotional biases. Targeting emotional biases could potentially help improve the core symptoms of irritability and short-temperedness among these individuals. Emotional biases refer to the preferential allocation of attention toward emotional stimuli. A recent study reported the presence of emotional biases among individuals with ADHD when they compared individuals with ADHD with those without. Gamification technologies have been explored to help diminish the repetitiveness of the task and increase the intrinsic motivation to train. These inconsistent findings of the impact of gaming on the effectiveness of mobile interventions call for further work to better understand the needs of patients (users) and health care professionals.

Objective
The aim of this research study is to collate health care professionals’ perspectives on the limitations of the existing task, and to determine if gamification elements could be incorporated, to refine the conventional intervention.

Methods
A qualitative research approach, that of a focus group, will be used. Health care professionals from the Department of Development Psychiatry, Institute of Mental Health, Singapore will be invited to participate in this qualitative research. During the focus group, participants are to comment on the limitations of the existing emotional bias intervention; recommend strategies to improve the intervention; and provide their perspectives pertaining to the use of gamification to improve the intervention.

Results
We expect that the study will be completed in 12 months from the publication of this protocol.

Conclusions
To our best knowledge, this is perhaps one of the only few studies that have attempted to explore emotional biases among adolescents with ADHD.

International Registered Report Identifier (IRRID)
PRR1-10.2196/24078
Evaluasi Posisi Geometrik Model 3D Candi Prambanan pada Aplikasi Augmented Reality berbasis GPS
Authors: Wahid Helmi Nurul , Aditya Trias 
Published: November 2020

Candi Prambanan merupakan kompleks bangunan peninggalan kerajaan Mataram Kuno yang pernah berjaya di Pulau Jawa. Statusnya sebagai situs warisan dunia dari UNESCO menjadikan bangunan bersejarah ini menjadi salah satu destinasi wisata yang terkenal di Daerah Istimewa Yogyakarta. Digitalisasi Pembuatan model tiga dimensi (3D) obyek candi merupakan salah satu program pelestarian budaya. Salah satu teknik rekonstruksi digital bangunan budaya adalah pemanfataan teknologi Augmented Reality (AR) berbasis posisi dari Global Positioning Systems dari piranti telpon. Fokus utama dari paper ini adalah menyajikan nilai akurasi dan respon pengguna terhadap kesalahan posisi obyek digital 3D candi yang ditampilkan melalui AR pada piranti telpon. Pengujian yang dilakukan adalah pengukuran ketelitian posisi dengan mengukur kesalahan jarak rata-rata model, serta persepsi respon pengguna. Pada penelitian ini, rata-rata kesalahan posisi model 3D pada aplikasi GPS AR yang ditampilkan adalah 2,208 ± 0,402 m dari koordinat lokasi yang dimasukkan pada sistem. Berdasarkan evaluasi pengguna, penyajian model 3D Candi Prambanan memperoleh nilai penerimaan pengguna sebesar 96,67% untuk perihal ketepatan posisi objek dan sebesar 53,33% untuk stabilitas tampilan objek 3D. Secara keseluruhan, nilai pemanfaatan aplikasi GPS AR untuk visualisasi candi sebesar 79,16%, dengan nilai hasil pengujian model 3D yang terletak di Candi Prambanan sebesar 78,33% dan pengujian di luar area kompleks sebesar 80%.
FORMULATION AND IN VITRO EVALUATION OF CURCUMIN LOADED JACKFRUIT SEED STARCH NANOPARTICLES
Authors: NATH JUNMONI 
Published: November 2020

Objectives: To meet the above aim the following objectives are undertaken: (1) Isolation of starch from jackfruit seeds and formulation of curcumin loaded jackfruit seed starch nanoparticles (2) In vitro evaluations of the drug loaded nanoparticles
Methods: Jackfruit seed starch nanoparticles were prepared by Nanoprecipitation technique. In this technique, jackfruit seed starch was mixed with curcumin and acetone solution using a magnetic stirrer at 600 rpm. To the above solution, water were added dropwise and stirred at room temperature until acetone was completely vaporized. Nanoparticles were separated by centrifugation at 4000 rpm after 40 min.
Results: Particle size of prepared nanoparticle formulations was found to be 371 to 411.72 nm with PDI of 0.148 to 0.356. The maximum % drug entrapment was found to be 57.34 % with formulation F5. In vitro release studies showed sustained release of drug till 12 h.
Conclusion: The prepared nanoparticles were evaluated for its particle size, drug entrapment efficiency, in vitro drug release study, and surface morphology studies by scanning electron microscopy. The results of Fourier transform infrared studies of 1:1 physical mixture of drug and excipients confirmed the absence of incompatibility. Thus, the study concludes that curcumin loaded jackfruit seed starch nanoparticles were developed successfully by nanoprecipitation, which is expected to enhance the oral bioavailability of curcumin.
IN VITRO EFFICACY TESTING OF NEEM (AZADIRACHTA INDICA) EXTRACT AGAINST AEROBIC AND ANAEROBIC BACTERIA
Authors: S. R. AKSHAYA , BHUVANESHWARI G. , GRACE J. R. LILLY , VENNILA ROSY 
Published: November 2020

Objective: To experiment the antimicrobial susceptibility of crude extract from neem (Azadirachta indica) leaves against Staphylococcus aureus, Escherichia coli and Clostridium perfringens.
Methods: Through the water extraction method, the aqueous crude extract of neem leaves were obtained. Separate colonies of Staphylococcus aureus, Escherichia coli and Clostridium perfringens were isolated and identified on different agars. Agar cup diffusion method was done to test the antimicrobial susceptibility of the neem leaves crude extract against those bacteria on Mueller-Hinton agar. Susceptibility was determined based on the zone of inhibition formed on the agar of each bacterium culture.
Result: Neem was effective against Staphylococcus aureus and Clostridium perfringens. It was not effective against Escherichia coli.
Conclusion: Neem extract has some promisable antimicrobial effects against Staphylococcus aureus and Clostridium perfringens causative bacterial infections.
Perlindungan Hukum terhadap Hak Milik Atas Tanah untuk Pembangunan Kepentingan Umum
Authors: Suryatika Made Ayu Wangi Utari , Suryawan I Gusti Bagus , Arthanaya I Wayan 
Published: November 2020

The role of land is very important in addition to being the capital for administering the life of the state but also the life of the people. Land function as the fulfillment of human needs in many aspects such as for housing, agriculture, plantations, and industrial activities that require the availability of land. Land has a social function, where one of the government's efforts in the context of national development is development in the public interest, such as the construction of highways, people's settlements, traditional markets, construction of mall buildings and so on. So the problem under investigation is What is the form of legal protection of land rights for the development of public interests, and how is the mechanism for compensating land rights for development of public interests. The method used is normative legal research with legislation and conceptual approaches, as well as sources of legal materials used are primary and secondary legal materials with collection techniques of library legal materials that are analyzed quantitatively in a descriptive analytical form. Based on the results of research and analysis, a conclusion can be drawn from legal protection of land rights that there are two forms of legal protection, namely preventive legal protection and repressive legal protection, in addition, Article 1 number 10 of Law No. 2 of 2012 is the basis of compensation for holders of land rights. The advice that can be delivered is that in practice the holders of land rights are often not satisfied with the compensation provided, according to which the amount of compensation is not proportional to material and material losses. Therefore, it is expected that the government as the land acquisition party applies an objective objectivity where careful consideration and calculation are carried out, so that the compensation as expected by the holder of the right to the land and even later the compensation can become compensation.
Kedudukan Bank Indonesia (BI) sebagai Pemohon Pailit Setelah Berdirinya Otoritas Jasa Keuangan (OJK)
Authors: Mudita I Komang Mudita , Sujana I Nyoman , Arini Desak Gde Dwi 
Published: November 2020

In its development banking institutions play a very important role and Act Number 3 of 2004 concerning About Bank Indonesia. After the birth of Law Number 21 of 2011 concerning the Financial Services Authority. It is very

interesting to study. What are the considerations taken by Bank Indonesia as a Bankrupt Petitioner after the existence of the Financial Services Authority and What is the Role of Bank Indonesia in Resolving Bankrupt Requests Against Banks. In this study the author uses the type of normative research from primary legal sources secondary legal materials. Article 2 paragraph (3) No. 37 of 2004 concerning Bankruptcy and Suspension of Debt Payment Obligations gives Bank Indonesia sole authority to submit bankruptcy applications to banks as creditors. the results of this study indicate that the authority to submit bankruptcy bank applications after the establishment of the Financial Services Authority the Financial Services Authority is to take into account whether the banks status has a systemic impact when the bank is filed for bankruptcy statements. The Financial Services Authority in this case can request consideration with Bank Indonesia about systemic impact of a bank. But the fact is Bank Indonesia still has authority of macropudentials
Upaya Hukum Praperadilan dalam Sistem Peradilan Pidana di Indonesia
Authors: Kusuma I Made Wisnu Wijaya , Sepud I Made , Karma Ni Made Sukaryati 
Published: November 2020

Criminal justice system and Indonesian criminal procedural law adhere to presumption of innocence.So, a person must protect his human rights. KUHAP formed a new institution, namely pretrial. Based on this research authors raise formulation problems: 1. How pretrial regulation criminal justice system Indonesia, 2. How validity pretrial that has not been decided if the subject matter case has been tried. Type research used normative. approach method used statutory approach, shortening analysis legal concepts. pre-trial authority according to Article 77 Criminal Procedure Code examines whether or not coercive measures are arrest and detention well examine whether or not termination investigation or prosecution, compensation and rehabilitation legal or not. Judge Sarpin stated that Sprindik, which became the basis for Budi Gunawan's investigation, was invalid. pretrial regulations are regulated Law No. 8 of 1981 on Criminal Procedure Law in article 77 Criminal Procedure Code, namely pretrial, which authority district court examine and decide, Constitutional Court Number 21/PUU -XII/2014, authority pre-trial institution also includes whether or not determination suspects valid, searches and confiscation. Validity investigations carried out by KPK regarding determination suspect Budi Gunawan was invalid therefore determination had no binding legal force. The Subject matter pretrial case being tried declared null and void.
Создание биоцидных препаратов «Тефлекс»: от синтеза нового полимера до линейки продукции. Часть 2. Исследование влияния препаратов «Тефлекс» на свойства цементных композитов
Authors: Erofeev Vladimir , Svetlov Dmitry , Smirnov Vasily , Fedortsov Anatoly , Kaznacheev Sergey , Bogatov Andrey , Rodin Alexander , Kraeva Lyudmila 
Published: November 2020

Повреждения строительных материалов, вызванные ро­стом и развитием на них бактерий и мицелиальных грибов представляют серьёзную опасность как для конструкций зданий и сооружений, так и для здоровья людей. Один из эффективных способов устранения данных негативных фак­торов - это введение в их состав биоцидных добавок.
Приводятся результаты исследования свойств цементных композитов, содержащих в своем составе различные био­цидные препараты на основе гуанидиновой группировки (ПГМГ), которые выпускаются в РФ в промышленном масштабе под маркой «Тефлекс». При выполнении исследований рас­сматривались препараты марок: «Тефлекс Антиплесень», «Тефлекс Антисоль смывка», «Тефлекс Реставратор», «Тефлекс Защита для металла», «Тефлекс дезинфицирующий», «Тефлекс индустриальный». Показано, что применение биоцидных препаратов способствует снижению обрастаемости образцов цементных композитов мицелиальными грибами и проявле­ние у них грибостойких и фунгицидных свойств.
С использованием метода рентгеноструктурного анализа выявлено, что при введении в составы соединений гуанидина изменяется количественное содержание минералов алита и белита. Исследованы цементные композиты, твердеющие как в нормальных температурно-влажностных условиях, так и подвергнутые термовлажностной обработке. Установлено, что введение всех рассмотренных добавок оказывает пластифи­цирующее действие и изменяет ряд других свойств. Прочность цементных композитов с добавками в количестве 3-5 мас. ч увеличивается. Приведены результаты исследования свойств композитов, наполненных кварцевыми порошками различной дисперсности и препаратом «Тефлекс». При этом наряду с одно­фракционными рассматривались многофракционные составы. Полученные результаты дают основание рекомендовать цемент­ные композиции, содержащие добавки на основе гуанидина, для использования в зданиях и сооружениях с биологическими средами. Приведены сведения о результатах использования цементных материалов и изделий в строительной отрасли.
Построение концептуальной конфайнмент-модели базы знаний технической диагностики зданий и сооружений
Authors: Kashevarova Galina 
Published: November 2020

Своевременная техническая диагностика конструкций зданий и сооружений является важным условием обеспе­чения их безопасности. Объективность и достоверность информации, предоставляемой экспертами о техническом состоянии строительного объекта, в большой степени зависят от опыта эксперта, то есть от человеческого фактора.
Внедрение интеллектуальных технологий в экспертную деятельность инженера-строителя мотивировано необходи­мостью передачи знаний опытных экспертов специалистам разной квалификации для расширения и укрепления их профессиональных возможностей. Логика рассуждений человека-эксперта в интеллектуальной системе должна легко поддаваться машинной обработке. Для этого её необходимо структурировать в виде концептуальной схемы системы знаний.
Представлен эффективный метод конфайнмент-моделирования на примере создания концептуальной структуры базы знаний (БЗ) технической диагностики конструкций зданий и сооружений, который позволяет унифицировать процесс разработки онтологических баз знаний, помогает от­сеивать неважные факторы и сосредоточиться на тех, которые действительно влияют на результат. Разработанная структура является основой для реализации следующего этапа - по­строения интегрированной базы знаний интеллектуальной системы диагностики технического состояния строительных объектов разных конструктивных форм и назначения, вы­полненных из разных материалов, которая должна также включать: методы цифровой обработки результатов лазерного сканирования повреждений конструкций; методы оценки ри­сков и определения остаточного ресурса конструкций зданий и сооружений с использованием теории нечётких множеств и нечёткой логики; оценку экономического эффекта от ме­роприятий по обеспечению конструкционной безопасности.