bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanical loading recovers bone but not muscle lost during unloading
Authors: Krause Andrew R. , Speacht Toni A. , Steiner Jennifer L. , Lang Charles H. , Donahue Henry J. 
Published: December 2020

AbstractSpace travel and prolonged bed rest are examples of mechanical unloading that induce significant muscle and bone loss. The compromised structure and function of bone and muscle owing to unloading make the reloading period a high risk for injury. To explore interactions between skeletal bone and muscle during reloading, we hypothesized that acute external mechanical loading of bone in combination with re-ambulation facilitates the proportional recovery of bone and muscle lost during hind limb suspension (HLS) unloading. Adult male C57Bl/6J mice were randomly assigned to a HLS or time-matched ground control (GC) group. After 2-weeks of HLS, separate groups of mice were studied at day 14 (no re-ambulation), day 28 (14 days re-ambulation) and day 56 (42 days re-ambulation); throughout the re-ambulation period, one limb received compressive mechanical loading and the contralateral limb served as an internal control. HLS induced loss of trabecular bone volume (BV/TV; −51 ± 2%) and muscle weight (−15 ± 2%) compared to GC at day 14. At day 28, the left tibia (re-ambulation only) of HLS mice had recovered approximately 20% of BV/TV lost during HLS, while the right tibia (re-ambulation and acute external mechanical loading) recovered to GC values of BV/TV (~100% recovery). At day 56, the right tibia continued to recover bone for some outcomes (trabecular BV/TV, trabecular thickness), while the left limb did not. Cortical bone displayed a delayed response to HLS, with a 10% greater decrease in BV/TV at day 28 compared to day 14. In contrast to bone, acute external mechanical loading during the re-ambulation period did not significantly increase muscle mass or protein synthesis in the gastrocnemius, compared to re-ambulation alone. Our results suggest acute external mechanical loading facilitates the recovery of bone during reloading following HLS unloading, but this does not translate to a concomitant recovery of muscle mass.
Use of electrochemical current noise method to monitor carbon steel corrosion under mineral wool insulation
Authors: Hou Yang , Pojtanabuntoeng Thunyaluk , Iannuzzi Mariano 
Published: December 2020

AbstractCorrosion of carbon steel under mineral wool insulation was studied using the electrochemical current noise (ECN) method. Intensities of corrosion were validated using gravimetry, and the form of corrosion confirmed using optical microscopy. The standard deviation of the current noise signal agreed with weight loss results and was demonstrated as a reliable indicator of the degree of corrosion under mineral wool insulation. Recurrence quantification analysis was used to extract feature variables from ECN signals, which were later used to develop a random forest model to identify the type of corrosion, i.e., uniform or localised corrosion. The trained model was successfully applied to predict the extent of localised corrosion associated with mineral wool insulation.
Localized UV emitters on the surface of β-Ga2O3
Authors: Huso Jesse , McCluskey Matthew D. , Yu Yinchuan , Islam Md Minhazul , Selim Farida 
Published: December 2020

AbstractMonoclinic gallium oxide (β-Ga2O3) is attracting intense focus as a material for power electronics, thanks to its ultra-wide bandgap (4.5–4.8 eV) and ability to be easily doped n-type. Because the holes self-trap, the band-edge luminescence is weak; hence, β-Ga2O3 has not been regarded as a promising material for light emission. In this work, optical and structural imaging methods revealed the presence of localized surface defects that emit in the near-UV (3.27 eV, 380 nm) when excited by sub-bandgap light. The PL emission of these centers is extremely bright—50 times brighter than that of single-crystal ZnO, a direct-gap semiconductor that has been touted as an active material for UV devices.
Numerical analysis of photonic crystal fiber of ultra-high birefringence and high nonlinearity
Authors: Agbemabiese Patrick Atsu , Akowuah Emmanuel Kofi 
Published: December 2020

AbstractA numerical analysis of a hexagonal PCF structure with four circular air hole rings around the core has been presented in this paper. By utilizing a full vectorial finite element method with perfectly matched layers, propagation properties such as birefringence, chromatic dispersion and confinement losses are numericaly evaluated for the proposed PCF structure. Specifically, birefringence of 2.018 × 10–2, nonlinear coefficients of 40.682 W−1 km−1, negative chromatic dispersion of − 47.72 ps/km.nm at 1.55 µm and − 21 to − 105 ps/km.nm at the telecommunication band of C-U have been reported.
Children’s coordination of the “sweet spot” when striking a forehand is shaped by the equipment used
Authors: Buszard Tim , Garofolini Alessandro , Whiteside David , Farrow Damian , Reid Machar 
Published: December 2020

AbstractChildren’s movement coordination is significantly influenced by the equipment used when performing multi-articular actions. Previously we reported that scaled equipment (smaller racket and a softer ball), but not full-sized equipment, promoted a functional coupling between upper arm and forearm angles in children performing a forehand. However, it remains unclear whether the shoulder-racket distance—which is controlled by this coupling—is a performance variable. This study therefore advanced previous research by examining whether the shoulder-racket distance is associated with performance. We also improved our understanding of how the shoulder-racket distance is controlled by including the hand-racket segment in our biomechanical model. Twenty-one children performed 40 forehands in a hitting for accuracy task. Participants were randomly divided into two groups—a scaled equipment group and a full-sized equipment group. Results revealed that the shoulder-racket distance was a performance variable, as evidenced by: (a) its variance reduced closer to ball impact, (b) its distance at ball impact, but not at the start of the forward swing, differentiated good from poor performance, and (c) its distance was similar for both groups, implying that there was a “sweet spot” for striking a ball, regardless of racket size. We also showed that it is the shoulder-racket vector in state-space (i.e., distance and angle) that differentiates good from poor performance. Finally, the manner in which the shoulder-racket distance was controlled differed between the groups, with scaled equipment promoting a more distal control than full-sized equipment. Implications for skill acquisition are discussed.
Social cues can impact complex behavior unconsciously
Authors: Schütz Christoph , Güldenpenning Iris , Koester Dirk , Schack Thomas 
Published: December 2020

AbstractIn three experiments, we investigated the effect of unconscious social priming on human behavior in a choice reaction time task. Photographs of a basketball player passing a ball to the left/right were used as target stimuli. Participants had to respond to the pass direction either by a whole-body (complex) response or a button-press (simple) response. Visually masked stimuli, showing both a task-relevant cue (pass direction) and a task-irrelevant, social cue (gaze direction), were used as primes. Subliminal social priming was found for kinematic (center of pressure) and chronometric measures (response times): gaze direction in the primes affected responses to the pass direction in the targets. The social priming effect diminished when gaze information was unhelpful or even detrimental to the task. Social priming of a complex behavior does not require awareness or intentionality, indicating automatic processing. Nevertheless, it can be controlled by top-down, strategic processes.
Human proximity suppresses fish recruitment by altering mangrove-associated odour cues
Authors: Brooker Rohan M. , Seyfferth Angelia L. , Hunter Alesia , Sneed Jennifer M. , Dixson Danielle L. , Hay Mark E. 
Published: December 2020

AbstractHuman-driven threats to coastal marine communities could potentially affect chemically mediated behaviours that have evolved to facilitate crucial ecological processes. Chemical cues and their importance remain inadequately understood in marine systems, but cues from coastal vegetation can provide sensory information guiding aquatic animals to key resources or habitats. In the tropics, mangroves are a ubiquitous component of healthy coastal ecosystems, associated with a range of habitats from river mouths to coral reefs. Because mangrove leaf litter is a predictable cue to coastal habitats, chemical information from mangrove leaves could provide a source of settlement cues for coastal fishes, drawing larvae towards shallow benthic habitats or inducing settlement. In choice assays, juvenile fishes from the Caribbean (Belize) and Indo-Pacific (Fiji) were attracted to cues from mangroves leaves and were more attracted to cues from mangroves distant from human settlement. In the field, experimental reefs supplemented with mangrove leaves grown away from humans attracted more fish recruits from a greater diversity of species than reefs supplemented with leaves grown near humans. Together, this suggests that human use of coastal areas alters natural chemical cues, negatively affecting the behavioural responses of larval fishes and potentially suppressing recruitment. Overall, our findings highlight the critical links that exist between marine and terrestrial habitats, and the importance of considering these in the broader conservation and management of coastal ecosystems.
Innovative microfossil (radiolarian) analysis using a system for automated image collection and AI-based classification of species
Authors: Itaki Takuya , Taira Yosuke , Kuwamori Naoki , Saito Hitoshi , Ikehara Minoru , Hoshino Tatsuhiko 
Published: December 2020

AbstractMicrofossils are a powerful tool in earth sciences, and they have been widely used for the determination of geological age and in paleoenvironmental studies. However, the identification of fossil species requires considerable time and labor by experts with extensive knowledge and experience. In this study, we successfully automated the acquisition of microfossil data using an artificial intelligence system that employs a computer-controlled microscope and deep learning methods. The system was used to calculate changes in the relative abundance (%) of Cycladophora davisiana, a siliceous microfossil species (Radiolaria) that is widely used as a stratigraphic tool in studies on Pleistocene sediments in the Southern Ocean. The estimates obtained using this system were consistent with the results obtained by a human expert (< ± 3.2%). In terms of efficiency, the developed system was capable of performing the classification tasks approximately three times faster than a human expert performing the same task.
A stress test to evaluate the usefulness of Akaike information criterion in short-term earthquake prediction
Authors: Tozzi Roberta , Masci Fabrizio , Pezzopane Michael 
Published: December 2020

AbstractAkaike information criterion (AIC) has been recently adopted to identify possible earthquake precursors in ionospheric total electron content (TEC). According to the authors of this methodology, their technique allows finding abrupt increases (positive breaks) in vertical TEC rate of change 25–80 min before the occurrence of large earthquakes, highlighting a promising implication of AIC method in Mw > 8 earthquakes alert strategies. Due to the relevance of this matter, a lively scientific debate ensued from these results. In this study, we carefully evaluate AIC method potentiality in searching earthquake TEC precursory signatures. We first investigate the dependence of the detected breaks number on the adjustable AIC method parameters. Then, we show that breaks occurrence clusters around specific local times and around moderate and high solar and geomagnetic activity. The outcome of this study is that AIC method is not concretely usable for issuing large earthquakes alerts.
The phylogenomics of CRISPR-Cas system and revelation of its features in Salmonella
Authors: Kushwaha Simran Krishnakant , Bhavesh Narra Lakshmi Sai , Abdella Bahaa , Lahiri Chandrajit , Marathe Sandhya Amol 
Published: December 2020

AbstractSalmonellae display intricate evolutionary patterns comprising over 2500 serovars having diverse pathogenic profiles. The acquisition and/or exchange of various virulence factors influences the evolutionary framework. To gain insights into evolution of Salmonella in association with the CRISPR-Cas genes we performed phylogenetic surveillance across strains of 22 Salmonella serovars. The strains differed in their CRISPR1-leader and cas operon features assorting into two main clades, CRISPR1-STY/cas-STY and CRISPR1-STM/cas-STM, comprising majorly typhoidal and non-typhoidal Salmonella serovars respectively. Serovars of these two clades displayed better relatedness, concerning CRISPR1-leader and cas operon, across genera than between themselves. This signifies the acquisition of CRISPR1/Cas region could be through a horizontal gene transfer event owing to the presence of mobile genetic elements flanking CRISPR1 array. Comparison of CRISPR and cas phenograms with that of multilocus sequence typing (MLST) suggests differential evolution of CRISPR/Cas system. As opposed to broad-host-range, the host-specific serovars harbor fewer spacers. Mapping of protospacer sources suggested a partial correlation of spacer content with habitat diversity of the serovars. Some serovars like serovar Enteritidis and Typhimurium that inhabit similar environment/infect similar hosts hardly shared their protospacer sources.
Tailoring of silica-based nanoporous pod by spermidine multi-activity
Authors: Della Rosa Giulia , Di Corato Riccardo , Carpi Sara , Polini Beatrice , Taurino Antonietta , Tedeschi Lorena , Nieri Paola , Rinaldi Rosaria , Aloisi Alessandra 
Published: December 2020

AbstractUbiquitous in nature, polyamines (PAs) are a class of low-molecular aliphatic amines critically involved in cell growth, survival and differentiation. The polycation behavior is validated as a successful strategy in delivery systems to enhance oligonucleotide loading and cellular uptake. In this study, the chemical features and the functional roles of the PA spermidine are synergistically exploited in the synthesis and bioactive functionalization of SiO2-based structures. Inspired by biosilicification, the role of spermidine is assessed both as catalyst and template in a biomimetic one-pot synthesis of dense silica-based particles (SPs) and as a competitive agent in an interfacial reassembly strategy, to empty out SPs and generate spermidine-decorated hollow silica nanoporous pods (spd-SNPs). Spermidine bioactivity is then employed for targeting tumor cell over-expressed polyamine transport system (PTS) and for effective delivery of functional miRNA into melanoma cells. Spermidine decoration promotes spd-SNP cell internalization mediated by PTS and along with hollow structure enhances oligonucleotide loading. Accordingly, the functional delivery of the tumor suppressor miR-34a 3p resulted in intracellular accumulation of histone-complexed DNA fragments associated with apoptosis. Overall, the results highlight the potential of spd-SNP as a multi-agent anticancer therapy.
Characterization and flowability methods for metal powders
Authors: Zegzulka Jiri , Gelnar Daniel , Jezerska Lucie , Prokes Rostislav , Rozbroj Jiri 
Published: December 2020

AbstractWith the rise of additive technologies, the characterization of metal powders is increasingly required. There is a need to precisely match the properties of metal powders to a specific machine and to ensure highly consistent production. Therefore, the study aims at a detailed characterization of ten metal powders (Metal powder 316 L, Zn, Sn, Al, Cu, Mn, Fe, Bronze, Ti and Mo powder), for which the particle size distribution, morphology, static and dynamic angle of repose and the effective internal friction angle (AIFE) were determined. The AIFE parameter and flow index were determined from three commonly used rotary shear devices: The computer-controlled Ring Shear Tester RST-01. pc, the Brookfield PFT Powder Flow Tester and the FT4 Powder rheometer. The results showed that the values ​​for the device of one manufacturer did not fully correspond to the values ​​of another one. The flow characteristics of the metal powders were quantified from the particle size distribution data, static angle of repose, and AIFE data. According to the particle size distribution and angle of repose (AOR), 50% of the tested metal powders fell into the free-flowing mode. According to the evaluation of AIFE, 20% of the samples fell into the lower area. Based on the flow indexes calculated from the measurements of the shear devices used, 100% (RST-01.pc), 70% (PFT) and 50% (FT4) of the samples were included in the free-flowing category. When comparing the results, attention should be paid not only to the nature of the material, but also to the methodology and equipment used. A comparison of methodologies revealed similarities in the changing behavior of the different metal powders. A comparison of effective angles of AIFE and static AOR was shown, and a hypothesis of the conversion relation was derived.
Estimating hunting harvest from partial reporting: a Bayesian approach
Authors: Lindström Tom , Bergqvist Göran 
Published: December 2020

AbstractQuantifying hunting harvest is essential for numerous ecological topics, necessitating reliable estimates. We here propose novel analytical tools for this purpose. Using a hierarchical Bayesian framework, we introduce models for hunting reports that accounts for different structures of the data. Focusing on Swedish harvest reports of red fox (Vulpes vulpes), wild boar (Sus scrofa), European pine marten (Martes martes), and Eurasian beaver (Castor fiber), we evaluated predictive performance through training and validation sets as well as Leave One Out Cross Validation. The analyses revealed that to provide reliable harvest estimates, analyses must account for both random variability among hunting teams and the effect of hunting area per team on the harvest rate. Disregarding the former underestimated the uncertainty, especially at finer spatial resolutions (county and hunting management precincts). Disregarding the latter imposed a bias that overestimated total harvest. We also found support for association between average harvest rate and variability, yet the direction of the association varied among species. However, this feature proved less important for predictive purposes. Importantly, the hierarchical Bayesian framework improved previously used point estimates by reducing sensitivity to low reporting and presenting inherent uncertainties.
Intravenous thrombolysis or mechanical thrombectomy do not increase risk of acute symptomatic seizures in patients with ischemic stroke
Authors: Zöllner Johann Philipp , Misselwitz Björn , Mauroschat Thomas , Roth Christian , Steinmetz Helmuth , Rosenow Felix , Strzelczyk Adam 
Published: December 2020

AbstractRecent data have suggested that performing recanalizing therapies in ischemic stroke might lead to an increased risk of acute symptomatic seizures. This applies to both intravenous thrombolysis and mechanical thrombectomy. We therefore determined the frequency of acute symptomatic seizures attributable to these two recanalization therapies using a large, population-based stroke registry in Central Europe. We performed two matched 1:1 case–control analyses. In both analyses, patients were matched for age, stroke severity on admission and pre-stroke functional status. The first analysis compared patients treated with intravenous thrombolysis to a non-recanalization control group. To isolate the effect of mechanical thrombectomy, we compared patients with both mechanical thrombectomy and intravenous thrombolysis to those with only intravenous thrombolysis treatment in a second analysis. From 135,117 patients in the database, 13,356 patients treated with only intravenous thrombolysis, and 1013 patients treated with both intravenous thrombolysis and mechanical thrombectomy were each matched to an equivalent number of controls. Patients with intravenous thrombolysis did not suffer from clinically apparent acute symptomatic seizures significantly more often than non-recanalized patients (treatment = 199; 1.5% vs. control = 237; 1.8%, p = 0.07). Mechanical thrombectomy in addition to intravenous thrombolysis also was not associated with an increased risk of acute symptomatic seizures, as the same number of patients suffered from seizures in the treatment and control group (both n = 17; 1.7%, p = 1). In a large population-based stroke registry, the frequency of clinically apparent acute symptomatic seizures was not increased in patients who received either intravenous thrombolysis alone or in conjunction with mechanical thrombectomy.
Comparison of pre- and postoperative myocardial injuries on mortality after non-cardiac surgery: a retrospective analysis using an inverse probability weighting adjustment
Authors: Lee Seung-Hwa , Park Jungchan , Lee Jong-Hwan , Min Jeong Jin , Hong Kwan Young , Cho Hyojin , Carriere Keumhee , Ahn Joonghyun 
Published: December 2020

AbstractAlthough both pre- and postoperative myocardial injuries are strongly associated with an increased postoperative mortality, no study has directly compared the effects of pre- and postoperative myocardial injuries on 30-day mortality after non-cardiac surgery. Therefore, we evaluated and compared the effects of pre- and postoperative myocardial injury on 30-day mortality after non-cardiac surgery. From January 2010 to December 2016, patients undergoing non-cardiac surgery were stratified into either the normal (n = 3182), preoperative myocardial injury (n = 694), or postoperative myocardial injury (n = 756) groups according to the peak cardiac troponin value. Myocardial injury was defined as a sole elevation of cardiac troponin value above the 99th percentile upper reference limit without ischemic symptom using the 4th universal definition of myocardial infarction. Patients in the preoperative myocardial injury group were further divided into the attenuated (n = 177) or persistent myocardial injury group (n = 517) according to the normalization of cardiac troponin level in postoperative period. As the primary outcome, postoperative 30-day mortalities were compared among the groups using the weighted Cox proportional-hazards regression models with the inverse probability weighting. Compared with the normal group, postoperative 30-day mortality was increased significantly both in the pre- and postoperative myocardial injury groups (1.4% vs. 10.7%; hazard ratio [HR] 3.12; 95% confidence interval [CI] 1.62–6.01; p = 0.001 and 1.4% vs. 7.4%; HR 4.49; 95% CI 2.34–8.60; p < 0.001, respectively), however, there was no difference between the pre- and postoperative myocardial injury groups (HR, 1.44; 95% CI 0.79–2.64; p = 0.45). In addition, the attenuated myocardial injury group showed a significantly lower postoperative 30-day mortality than the persistent myocardial injury group (5.6% vs. 12.4%; HR 2.23; 95% CI 1.17–4.44; p = 0.02). In patients undergoing non-cardiac surgery, preoperative myocardial injury also increased postoperative 30-day mortality to a similar degree of postoperative myocardial injury. Further studies on the importance of preoperative myocardial injury are needed.Clinical trial number and registry URL: KCT0004348 (www.cris.nih.go.kr).