bluuebunny/crossref_metadata_2025_split huggingface dataset:
The cardiovascular complications of diabetes: a striking link through protein glycation
Authors: Ahmad Mousa Numan , Farah Amani Ibrahim , Al-Qirim Tareq Musbah 
Published: August 2020

Abstract
Diabetes mellitus is a predominant cause of mortality and morbidity worldwide. One of its serious health problems is cardiovascular complications. Advanced glycation end products (AGEs) are a group of heterogeneous toxic oxidant compounds that are formed after a non-enzymatic reaction between monosaccharides and free amino groups of proteins, compound lipids, and nucleic acids. AGE interacts with various types of cells through a receptor for AGE (RAGE). The interaction between AGE and RAGE is responsible for a cascade of inflammation, oxidative stress, and disruption of calcium homeostasis in cardiac cells of diabetic patients. There is striking evidence that the AGE/RAGE axis with its consequences on inflammation and oxidative stress plays a major role in the development of cardiovascular complications. Therefore, considering AGE as a therapeutic target with foreseeable results would be a wise direction for future research. Interestingly, several studies on nutraceutical, pharmaceutical, and natural products have begun to reveal promising therapeutic results, and this could lead to better health outcomes for many diabetic patients worldwide. This article discusses the current literature addressing the connection between protein glycation and diabetes cardiovascular complications and suggests future avenues of research.
SH2B3 (LNK) rs3184504 polymorphism is correlated with JAK2 V617F-positive myeloproliferative neoplasms
Authors: Trifa Adrian P. , Lighezan Diana L. , Jucan Cristina , Tripon Florin , Arbore Dana R. , Bojan Anca , Gligor-Popa Ștefana , Pop Raluca M. , Dima Delia , Bănescu Claudia 
Published: August 2020

Abstract

Background: Pathogenesis and phenotypic diversity in myeloproliferative neoplasms (MPN) cannot be fully explained by the currently known acquired mutations alone. Some susceptible germline variants of different genes have been proved to be associated with the development of these diseases. The goal of our study was to evaluate the association between the rs3184504 polymorphism of SH2B3 (LNK) gene (p.R262W, c.784T>C) and the risk of developing the four typical MPN - polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF), and chronic myeloid leukemia (CML).

Material and methods: We investigated the SH2B3 rs3184504 T>C polymorphism by real-time PCR in 1901 MPN patients (575 with PV, 798 with ET, 251 with PMF, and 277 with CML), all of them harboring one of the specific driver mutations - JAK2 V617F or CALR in case of PV, ET and PMF, or BCR-ABL1 in case of CML, and 359 controls.

Results: Overall, the TT homozygous genotype was significantly associated with BCR-ABL1-negative MPN (OR = 1.34; 95% CI = 1.03-1.74; crude p-value = 0.02; adjusted p-value = 0.04). The most significant association was seen in case of PV (OR = 1.54; 95% CI = 1.14-2.06; crude p-value = 0.004; adjusted p-value = 0.024). Also, SH2B3 rs3184504 correlated significantly with JAK2 V617F-positive MPN (OR = 1.36; 95% CI = 1.04-1.77; crude p-value = 0.02; adjusted p-value = 0.08), but not with those CALR-positive. ET (regardless of molecular subtype) and CML were not correlated with SH2B3 rs3184504.

Conclusions: The SH2B3 rs3184504 polymorphism is associated with risk of MPN development, especially PV. This effect is restricted to JAK2 V617F-positive PV and PMF only.
„Book Cover Analysis”
Authors: Nariţa Ionel 
Published: August 2020

Abstract
Throughout history, the authorities tried to prevent some messages to reach the members of organizations. For this goal, they used the method of criterion or the method of lists. The criterion method is not adequate since it asks the analysis of the text or body of discourse in order to be applied. Instead, the lists method can be used analyzing only the cover of the publications. At their turn, the lists are exclusive or inclusive. The exclusive lists, like Index Librorum Prohibitorum, include the works that should not be received by a certain public, while the inclusive lists contain the publications agreed by the authorities.
“The archetype of the pathetic man, between objectivation and objectification”
Authors: Stănese Radu 
Published: August 2020

Abstract
The study follows the archetype - prototype - stereotype path in the evolution of the plastic model, in order to capture the organic connection between these notions specific to iconic language. The chronology is reversed to capture a contemporary stereotype of advertising images, as a result of an apparent form of expression of female emancipation: the erotic objectification of man. Far from being just „trendy”, the visual motif has a whole history that deserves to be pointed out as the different approaches always reflect the spirit of that era.
“Mall Nihilism”
Authors: Enache Răzvan 
Published: August 2020

Abstract
We address Homo Sapiens, probably the most widely read book of Yuval Noah Harari, and we stress the weaknesses of the frame he uses to boldly interpret what can only harshly be considered a “history of mankind.” We argue that such an ambitious enterprise has to avoid shallowness and needs to be deeply philosophically-informed.
Cysatracurium dosing in gynecological laparoscopic surgery in obese patients
Authors: Polovnikov E. V. , Elizar’eva N. L. , Kolosov A. N. , Shmakov A. N. , Kokhno V. N. , Loktin E. M. 
Published: August 2020

Aim. Substantiation of cisatracurium dosing in routine gynaecological laparoscopic surgery in obese patients based on comparative development time and duration of the neuromuscular block.Materials and methods. The assay included 24 women with class II-III obesity and routine laparoscopic gynaecological surgery divided into two cohorts. In cohort 1, cisatracurium was dosed at 0.15 mg/kg ideal body weight estimated with the Lorentz formula. In cohort 2, cisatracurium dosing was 0.15 mg/kg real body weight.Results. Tracheal intubation and total operation doses of the relaxant were higher when rated for real body weight. Time between cysatracurium administration and maximal neuromuscular transmission inhibition was less in cohort 2, and recovery time of the ﬁrst response to stimulation — in cohort 1. Neuromuscular block recovery time to 25% TOF count and the recovery index did not differ signiﬁcantly between the cohorts.Conclusion. Cysatracurium dosage rated for ideal body weight resulted in a better controlled course of the neuromuscular block, whilst rating for real body weight resulted in a dose-dependent increase of the duration of action and total consumption rate of the relaxant.
Dynamics of registered alcohol-attributable mortality in Krasnodar Krai
Authors: Redko A. N. , Gubarev S. V. 
Published: August 2020

Aim. Description of current dynamics of registered alcohol-attributable mortality in Krasnodar Krai.Materials and methods. The study was conducted using ofﬁcial statistics reports and published materials of the Federal State Statistics Service. The survey covers 1,398,636 cases in Krasnodar Krai from 2000 to 2018, including 42,612 deaths from alcohol-related causes. Intensive (IM), extensive (EM) and standardised mortality (SM) rates were estimated according to the European Population Standard. Statistical analyses were performed with Microsoft Ofﬁce software.Results. Krasnodar Krai displays a positive trend of alcohol-attributable mortality (AAM), with a reduction rate 3.5 times above the similar total mortality (TMR) values (74.4 vs. 21.5%). The decline is more pronounced in both men and women compared to the country average. Thus, AAM in men and in women was 2.9 and 3.7 times lower, respectively, in Krasnodar Krai in 2018. At the same time, TMR values were similar, 1,245.2 against 1,200.6 per 100,000 population in the Russian Federation and Krasnodar Krai, respectively (p <0.05). Alcoholic cardiomyopathy, alcoholic liver disease and poisoning prevailed as causes of AAM for almost the entire period analysed, with their total cumulative contribution varying from 55.6 to 91.7%.We demonstrate a steady growth of AAM incidents subject to state registration in Form C-51 (from 4 in 2000 to 17 in 2018), which hampers a retrospective analysis of AAM dynamics in terms of individual nosologies’ contribution.Conclusion. The trends revealed objectively illustrate a positive AAM dynamics in Krasnodar Krai. However, overall contribution of alcohol-attributed causes to the current total mortality proﬁle of the population is underestimated. Recommendations in national healthcare are needed for step-wise improvement and strict supervision of statistical indicator reporting, particularly, of death causes associated with alcohol intake.
Efficacy of Computed Tomography Pulmonary Angiography as Non-invasive Imaging Biomarker for Risk Stratification of Acute Pulmonary Embolism
Authors: Higazi Mahmoud M. , Fattah Rasha Abdel Raouf Abdel , Abdelghany Elham Abdelhady , Ghany Hosny S. Abdel 
Published: August 2020

Objectives:
Massive and sub-massive pulmonary embolisms (PEs) are associated with high mortality and morbidity. The mainstay of treatment for PE is anticoagulation. However, high- and intermediate-risk patients may benefit from interventional thrombolytic therapy. Computed tomography pulmonary angiography (CTPA) is widely available, fast, and non-invasive technique, and it can identify pulmonary thrombus down to at least a segmental level. In this study, we attempt to evaluate the efficacy of CTPA as a non-invasive imaging biomarker for risk stratification of acute PE (APE) patients.

Material and Methods:
This is a prospective study conducted on 150 patients who proved to have APE by CTPA. The simplified PE severity index score was obtained. The pulmonary artery obstruction index (PAOI) using and right to left ventricular (RV/LV) diameter ratios were calculated.

Results:
The patients were divided into (1) high risk (shocked) and (2) non-high risk groups. There was a significant difference between the 1st and 2nd groups regarding PAOI. Hemodynamically stable patients were further subclassified according to the right ventricular dysfunction (RVD) into Group Ia (intermediate risk) and Group Ib (low risk). There was a significant difference between subgroups regarding PAOI (P < 0.0001, r = 0.385). Receiver operating characteristic curve analysis revealed PAOI >47% associated with RV/LV ratio >1.

Conclusion:
Our results support the use of CTPA as a surrogate imaging biomarker for both diagnosis and risk stratification of APE patients. CTPA allows assessment of clot burden through PAOI calculation and identification of intermediate-risk PE through the assessment of RVD.
Evaluation of Normal Morphology of Mandibular Condyle: A Radiographic Survey
Authors: Singh Bhupender , Kumar Nileena R. , Balan Anita , Nishan Mohammed , Haris P. S. , Jinisha M. , Denny C. Dimla 
Published: August 2020

Objectives:
The temporomandibular joint (TMJ) is a complex, highly specialized joint. Along with the teeth, these joints are considered to be a “tri-joint complex.” Mandibular condyle morphology is characterized by a rounded bone projection with an upper biconvex and oval surface in axial plane. Anatomical knowledge of the TMJ is one of the basic foundations of clinical practice, allowing the understanding of TMJ pathologies and fabrication of condylar prostheses. The cross-sectional descriptive study was undertaken to evaluate normal variation in the condylar morphology on radiographs in persons without TMJ symptomatology and its relation to age, gender, dentition status, chewing habits, parafunctional habits, history of orthodontic treatment, and denture wearing was assessed.

Material and Methods:
A total of 350 subjects without TMJ symptomatology included in the study were further grouped by age, gender, dentition status, chewing habits, parafunctional habits, history of orthodontic treatment, and denture wearing history. Panoramic radiograph was taken for the assessment of condylar morphology.

Results:
A significant association between dentition status and bilaterally similar condylar morphology was noticed. Bilaterally similar condyles were seen in 81.4% of subjects. Round-shaped condyles were seen in 176 (62%) persons. Loss of bilateral occlusion tends to alter the condylar morphology. Association between normal chewing habits and bilaterally similar condyle shapes was significant.

Conclusion:
The study describes the normal morphology of mandibular condyles in a population attending the tertiary dental care center, Kozhikode. The dentition status and chewing habits of individuals had a significant role in determining condylar morphology.
PENGATURAN SUMBER DAYA ALAM DI LANDAS KONTINEN SEHUBUNGAN DENGAN BERLAKUNYA KONVENSI HUKUM LAUT PBB 1982 KHUSUSNYA BAGI INDONESIA
Authors: Chalim Munsharif Abdul 
Published: August 2020

Continental shelf is a relatively new concept in international law of the sea. Full authority and exclusive rights over natural resources located in the continental shelf region and its ownership is on the coastal state, where the meaning of this natural wealth is a source of minerals and other lifeless on the seabed and subsoil. Through the establishment of the United Nations Convention on the Law of the Sea 1982, as well as enactment of the provisions of the New Law of the Sea, Indonesia is an archipelagic state which is seen as a unified whole between the islands and waters. We realized the sea was rich in minerals mining goods that is priceless natural resources, which is expected to be able to fulfill the needs of the world if mineral resources on land are not sufficient or run out completely. In Indonesia, mostly consisting of ocean territory, surely have the very wide continental shelf, where there is a variety of natural resources, especially oil and gas resources. Hence it needs regulation for the natural resources utilization in the region.Keywords :Â Continental Shelf, Natural Resources, Seabed and Subsoil.
Kebijakan Hukum Pidana dalam Upaya Penanggulangan Tindak Pidana Pers
Authors: Maerani Ira Alia 
Published: August 2020

Â Abad millenium ketiga salah satunya ditandai dengan desakan tumbuhnya kebebasan pers seiring dengan maraknya media pers yang mengikuti laju arus reformasi. Agar kebebasan pers berjalan sesuai dengan yang diharapkan, maka perlu diatur dalam sebuah aturan yang tidak mereduksi kebebasan pers itu sendiri. Sehingga pers tumbuh dan berkembang sesuai peran yang diamanatkan Pasal 28 Undang-Undang Dasar Negara Republik Indonesia (UUD NRI) Tahun 1945. Dalam tulisan ini akan diangkat bagaimana kebijakan hukum pidana dalam menanggulangi tindak pidana pers saat ini, yang diatur dalam Kitab Undang-Undang Hukum Pidana (KUHP) dan Undang-Undang No. 40 Tahun 1999 tentang Pers. Pokok permasalah kedua yang dikaji adalah bagaimana kebijakan hukum pidana dalam upaya menanggulangi tindak pidana pers yang akan datang selaku ius constituendum. Dalam tulisan ini, penulis menggunakan Konsep KUHP Tahun 2012 sebagai acuan.Kata kunci: Kebijakan, hukum pidana, penanggulangan tindak pidana pers.
Peranan Gate Keeper dalam Upaya Penanggulangan Tindak Pidana Pencucian Uang (Pengembalian Aset Kejahatan Hasil Korupsi)
Authors: Firmansyah Hery 
Published: August 2020

Tindak pidana pencucian uang merupakan sebuah topik yang hangat untuk dibicarakan dalam kajian hukum pidana dan ekonomi dalam beberapa waktu belakangan ini. Tindak pidana pencucian uang adalah suatu kegiatan kejahatan menyaring â€œuang kotorâ€ melalui serangkaian transaksi, sehingga para pelaku kejahatan pencucian uang dapat mengaburkan asal usul harta kekayaan dari suatu kejahatan kedalam suatu tindakan yang sah secara hukum. Kita tentunya memiliki kewajiban untuk memberikan perhatian terhadap situasi tersebut dengan cara memperkuat sistem antitindak pidana pencucian uang dalam hal mencegah pelaku tindak pidana pencucian uang menikmati hasil kejahatannya. Fokus lain dalam hal skema tindak pidana pencucian uang adalah penggunaan â€œgate keeperâ€ dalam lingkup jasa profesional seperti: pengacara, penasihat keuangan, dan akuntan. Hal ini juga menjadi kerja tambahan bagi pemerintah saat ini untuk melanjutkan upaya pengembangan kerjasama internasional dalam upaya melawan kejahatan pencucian uang. Rumusan masalah dalam tulisan ini adalah Pertama, Mengapa gate keeper memegang peranan penting dalam pemberantasan kejahatan money laundry? Kedua, Bagaimana upaya yang dapat dilakukan untuk memaksimalkan peran Gate Keeper dalam pengembalian aset kejahatan money laundry? Kesimpulan yang dapat diambil oleh penulis adalah Pertama, Gate Keeper dapat digunakan sebagai upaya untuk melacak keberadaan dan menarik kembali harta-harta negara yang dibawa kabur oleh koruptor. Khususnya dalam tahap layering di dalam TPPU gate keeper sangat berperan. Kedua, Memberikan perluasan pada definisi pelapor dalam tindak pidana pencucian uang, merupakan salah satu langkah awal yang dapat memperkecil peluang terjadinya pengaburan asal usul harta kekayaan yang berasal dari suatu kejahatan yang ingin dinikmati oleh pelaku.Â Hal lain yang penting dilakukan oleh pemerintah adalah melakukan kerjasama dengan negara lain, seperti dengan bantuan hukum timbal balik (dengan sebelumnya melakukan upaya asset tracing).Kata kunci: tindak pidana pencucian uang, gate keeper, uang kotorPeranan Gate Keeper dalam Upaya Penanggulangan Tindak Pidana Pencucian Uang (Pengembalian Aset Kejahatan Hasil Korupsi)
The Social Reaction for The Effort of Crime Prevention (In The Short Analizing)
Authors: Azhari Faisol 
Published: August 2020

Â Â Â Â Â Â Â Â Â Really, talking about the problem of the social reactionÂ for the crime and offenders in the development of criminology science are so important. Therefore in analizing for that case and Â how to solve about crimeÂ the criminology science isnâ€™t limmited about the background of crime only or law.Â Â Â Â Â Â The crime prevention is also explained by Criminology. Therefore Criminology is also include the study of the social reaction against crime. Edwin H Sutherland and Cressey said that the crime prevention or the social reaction against crime include within criminology. And really, accordance with the development of criminology science it needs the other sciences to support it in analizingÂ for crime and crime causation such as the anthropology science phsichology science sociology criminal science etc. There are several approaches analizing about the crime and the effort of crime prevention.Keywords: The crime prevention, The social reaction against crimeÂ
AN ANALYSIS ON SOCIO-ECONOMIC STATUS OF SCHEDULED CASTES POPULATION IN TIROL VILLAGE, ARAMBAGH, HOOGHLY
Authors: Sardar Sanjib 
Published: August 2020

The present paper is concerned with Socio-Economic background of Scheduled Castes (SCs) population in Tirol village, Arambagh and its major focus is to analyze the main obstacles on the way to socio-economic development. The basic information has been collected through the well-prepared questionnaire and supplemented by relevant secondary data. An intensive study was run over 287 sample household and the result was shown in the tabulated form. The outcome of the study reveals that 88.88 percentage sample population belong to SCs community and the percentage of men and women is 49.64 and 50.36 respectively. The educational level of the study area is not so good among the people of SCs community except the present generation and in terms of higher education the level is very poor. The rate of literacy among women is far behind than men although the number of women is more than men. The monthly income of SCs is not up to the mark. A large number of people of the SCs community are unemployed and the main economic activities are based on agriculture. They usually live in mud house, although there are several concrete houses built with the help of Indira Awas Yojana. So as a whole it is observed from the present study that, the socio-economic condition of SC community is poor and Government should pay attention to socio-economic backwardness and find requisite steps for sustainable development.
Future LIS Education and Evolving Global Competency Requirements for the Digital Information Environment: An Epistemological Overview
Authors: Raju Jaya 
Published: August 2020

In the context of an evolving digitally-oriented library and/or information science (LIS) discipline and framed by Andrew Abbott’s Chaos of Disciplines theory, this article presents an epistemological overview of evolving competency requirements for a global digital information environment and the implications of this for future LIS education. In doing so it draws from both an international case study of ongoing research by the IFLA BSLISE (Building Strong LIS Education) Working Group into the development of an international framework for the assessment of quality standards in LIS education and a national (South African) case study involving the compilation of an LIS competency index in a highly digitally oriented information environment. The Chaos of Disciplines theory was originally conceptualized to demonstrate the evolution of disciplines in the social sciences. Its core principles of the interstitial character of a discipline and fractal distinctions in time are employed as a heuristic tool to connect the empirical evidence from these two purposively selected case studies to the inherent nature of the LIS discipline and the implications of this for competency requirements for professional practice in a highly digitized global information environment and for future LIS education responding to these competency exigencies.
Tahsin Al-Qur’an untuk orang dewasa dalam perspektif Islam
Authors: Mujahidin Endin , Daudin Ahmad , Nurkholis Imam Ikhsan , Ismail Wahyudin 
Published: August 2020

<p class="16aJudulAbstrak"><em>The Quran is the word of Allah which was revealed to the prophet Muhammad saw gradually through the intermediary Angel Jibril and is a worship by reading it that begins with surah Al-Fatihah and ends with surah An-Nas. In the process of learning the Quran there are some methods that can be applied including the Tilawati method, Tahsin Tilawah method, Iqra method, Qira’ati method, Baghdadiyah method, and Ummi method. The Quran is also a scripture that is used as guidelines by Muslims, therefore everyone who is Muslim must be able to read it according to the rules that already exist. But in fact, there are still many Muslims who can not read the Quran. The research results of the Institute Ilmu Al-Qur’an (IIQ) shows that 65 percent of Indonesians are illiterate in the Quran (Republika). The purpose of this article is to find out how the Islamic perspective is to look at the study of Tahsin in the Quran for adults and to find out what obstacles might occur in the study of Tahsin for adults. This study uses the study library method.</em></p><p class="16aJudulAbstrak"> </p><p class="16aJudulAbstrak"><strong>Abstrak</strong></p><p class="16bIsiAbstrak">Al-Qur’an adalah kalam Allah yang diturunkan kepada Nabi Muhammad saw secara bertahap melalui perantara Malaikat Jibril dan merupakan sebuah pahala dengan membacanya, yang diawali surat Al-Fatihah dan diakhiri dengan surat An-Nas. Dalam proses pembelajaran Al-Qur’an terdapat beberapa metode yang bisa diterapkan diantaranya metode Tilawati, metode Tahsin Tilawah, metode Iqra, metode Qira’ati, metode Baghdadiyah, dan metode Ummi. Al-Qur’an juga merupakan kitab suci yang dijadikan pedoman oleh umat Islam, oleh karena itu setiap orang yang beragama Islam harus mampu membacanya sesuai dengan kaidah yang sudah ada. Namun pada kenyataannya, masih banyak umat Islam yang tidak bisa membaca Al-Qur’an. Dilansir dari Republika, hasil riset Institut Ilmu Al-Qur’an (IIQ) menunjukkan bahwa 65 persen masyarakat Indonesia buta huruf Al-Qur’an. Tujuan penulisan artikel ini adalah untuk mengetahui bagaimana perspektif Islam dalam memandang pembelajaran tahsin Al-Qur’an untuk dewasa dan untuk mengetahui apa saja hambatan yang mungkin terjadi dalam pembelajaran tahsin untuk dewasa. Penelitian ini menggunakan metode studi pustaka.</p><p class="15bIsiAbstractBInggris"> </p><p class="15cKeywordsBInggris"> </p>