bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scenario for applying the duality theory when planning production in the industry
Authors: Ershov A. T. , Gubareva E. A. , Nolde E. L. , Efimova M. V. 
Published: November 2020

The task of drawing up an optimal production plan for an enterprise with limited resources and problem solution of bridging production bottlenecks for only one enterprise are of limited interest. New technical capabilities due to the volume and speed of data transmission and processing, allow you to solve new problems in which the apparatus of the duality theory can be fully used.The authors consider the problem of planning the optimal production company (firm, industry, ministry) volume, which structurally has a certain coordinating (managing) center and a network of enterprises (branches), which can be located in different regions, and are not connected with each other. Each of the branches has its own technological matrix of resource costs for output, resource reserves, expected profit from the sale of each type of product unit.An iterative algorithm for finding production plans for each of the enterprises is proposed, when implementing which the total profit of the company can be increased. The Center finds the optimal production plan for each of the enterprises according to this algorithm and using the classical formula of the optimal production planning problem. Further, for each of them, the Center, solving the problem of resolving production bottlenecks for each of the enterprise, determines the supply volumes of resources scarce. The Center supplies scarce resources to enterprises and forms a new adjusted output plan for each of the enterprises. If it is impossible to supply scarce resources to meet the needs of all enterprises in the company, the options for the most promising planning models are offered, under which the total profit of all enterprises in the company will be the greatest.The implementation of the planning scenarios proposed below becomes real when switching to digital production management methods.
Development of marketing interaction between the university and students through the use of digital marketing tools and technologies
Authors: Ukhova A. I. 
Published: November 2020

The article considers the possibilities of developing marketing interaction of higher education organizations with stakeholders using digital marketing tools and technologies. The study presents an overview of the University stakeholder groups in Russia and their classification according to the quadrants of influence. The author provides the tools and means of digital marketing communications in the context of stakeholder groups and the prospects for their use for organizing marketing communicative interaction of the University. The paper studies in detail the possibilities of developing marketing interaction between the university and students on the basis of modeling the student’s experience on the path of his movement from the applicant to the graduate.The presented student experience includes six main stages, including the search for a University for admission; submission of documents and enrollment; educational and extracurricular activities; graduation and graduation; employment; career development. The author highlights within each stage of the student’s experience the main points of contact with the University. The paper presents opportunities for the development of marketing interaction between the University and students through the introduction of digital tools and marketing technologies, as well as their impact on the student experience model.The article considers the possibility of developing software services as promising digital tools and technologies for use in higher education organizations, including the functional requirements for such services at the level of user requirements, including the applicant and student, as well asthe possibilities of digital marketing communications with students, including both online and offline communications.Based on the study, the author makes a conclusion about the main advantages of the development of digital tools and marketing technologies in organizing marketing interaction between the University and students, as one of the key groups of stakeholders.
Development of Single Nucleotide Polymorphism (SNP) Markers in Tropical Crops
Authors: Dwiningsih Yheni , Rahmaningsih Miranti , Alkahtani Jawaher 
Published: November 2020

Understanding genetic diversity, association studies, evolution analysis, quantitative trait loci, marker-assisted selection and genome-wide association in tropical crops are important for improving plant characteristics in order to increase food sustainability in tropical countries. Single nucleotide polymorphism (SNP) marker is becoming the most popular molecular marker for those studies. By using SNP marker, genes associated with important traits can be identified efficiently compared to the other molecular markers. This review describes about how SNP can be discovered in the plant genomes and the application of SNP in plant breeding, especially in tropical crops such as rice, maize, peas, potato, tomato, cassava, taro, etc. Keywords: food sustainability, plant breeding, SNP marker, tropical crops
Characterization of Yellow Pigmented Bacteria Associated with Gracilaria sp.
Authors: Lunggani Arina Tri , Purwantisari Susianna , Jannah Siti Nur 
Published: November 2020

Research on the kinship analysis of endophytic bacterial isolated from Gracillaria sp has been carried out. The presence of bacteria associated with Gracilaria sp. has enabled the use of these bacteria as a source of new bioactive compounds, such as biopigments. The research aims to isolated bacteria from Gracilaria sp., screened their symbiont bacteria that could potentially produce pigments. Sampling Gracilaria sp. conducted in the waters of the Island of Karimunjawa, Jepara. Furthermore, bacterial isolation was carried out, screening for pigment-producing bacteria and 16S rRNA sequence analysis. Research result showed that the symbiont bacteria isolate TK 373 produced consistent pigments after several regenerations, in several types of growth media incubated at room temperature. The results of 16S rDNA identification showed that the TK 373 isolate had the closest relationship with Pseudoalteromonas sp. with 98.72 % homology.
OVERCOMING ABIOTIC SHADES FOR SWEETPOTATO (IPOMOEA BATATAS L.) IN THE HIGHLAND OF PAPUA, INDONESIA: THE ADAPTATION OF VARIETIES AND STICKS INCLINATION ANGLES
Authors: Soplanit Alberth , Guritno Bambang , Ariffin  , Suminarti NurEdy 
Published: November 2020

Abiotic shades due to the high level of cloud are the major problem causing a low level of sweetpotato (Ipomoea batatas L.) photosynthesis in the higland of Papua, Indonesia. In order to optimize the growth and production of sweetpotato, it needs to engineer the growing environment for the crop. This study aims to learn the growth, production and photosynthesis efficiency (Eµ) by combining varieties and sticks inclination angles on (1.560 m asl) from April to September 2016. It was conducted using a Split-Plot Design with three replications. The main plot was three sweet potato varietes: Siate, Papua Salosa and Cangkuang, while the subplot was the inclination of sticks with three angles: 90º, 60º, 45º and without using sticks. The result shows that a combination of Cangkuang and 90º stick inclination produces the highest total dry matter and tubers (326.9 g/plant and 248.7 g/plant respectively). The highest net assimilation rate was obtained in combination of Cangkuang with stick inclination angles treatments 90º and 60º for 125.2 mg.cm2.day-1 and 105.3 mg.cm2.day-1, the leaf area index ranged from 0.9-5.5. The highest tubers yield was achieved by the Cangkuang with 90º and 60º sticks inclination angles treatments, which are 31.53 t.ha-1 and 28.86 t.ha-1 respectively, with the harvest indexes around 36-62 %, in which the tubers yield and the harvest indexes have significant correlations.The highest photosynthesis efficiency was achieved by the Cangkuang with 90º (3.83 %) and 600 (3.34 %) sticks inclination angles treatments, while the lowest one was done by the Siate and without sticks (0.92 %) treatment. As a conclusion, the higher sticks inclination angles applied on the sweetpotato varieties, particularly whose wider leafs, under abiotic shade conditions may increase crop growth rates, total and tuber dry matters, tubers yield, harvest indexes, and photosynthesis efficiency rates.
BULL VS BEAR MARKET- AN INVESTMENT GAME ANALYSIS USING MOVING AVERAGE METHOD
Authors: Rout Biswajit , Mohanty Ayesha , Kacharia Akash Kumar 
Published: November 2020

This paper aims to analyse and interpret the investor perception about investing in stock market. The market is often referred as to bull or bear market. This is key importance for financial decisions and economic analysis. The market behaves differently in these two phase. The bull market is identified when there is constant rise of stock prices whereas bear market is referred when there is fall in stock prices. These phases occur due to different trends of market or economy. Investor sentiments get affected by this. The paper tries to identify and provides understanding about the factors that causes and how it affects the psychology of investors.
There are different analysis techniques used by analysts. The popular and common analysis theories are Fundamental Analysis and Technical Analysis. This paper is based on technical analysis of different category of stock with respect to wide spread industry like FMCG sector, Banking sector, Oil and Natural Gas sector, Automobiles sector and Pharmaceutical Sector etc. The paper also tries to establish whether the market is having a Bull Run or bear. The movement of stock prices is analysed in technical analysis. The data of stock prices are collected from NSE official site. The analysis in done for 5 years span starting from April 2012 to Mar 2017. Even to understand better, analysis of the stock is done on 100days moving average. Prevailing news during those times are also considered to interpret the behaviour of the investors.
Long-term outcomes in the treatment of pediatric skull base chordomas in the endoscopic endonasal era
Authors: McDowell Michael M. , Zwagerman Nathan T. , Wang Eric W. , Snyderman Carl H. , Tyler-Kabara Elizabeth C. , Gardner Paul A. 
Published: November 2020

OBJECTIVEPediatric skull base chordoma is a rare entity that is traditionally considered to display aggressive behavior with an increased risk of recurrence. There is an absence of literature examining outcomes in the pediatric population in general and using the endoscopic endonasal approach (EEA).METHODSThe authors retrospectively reviewed all patients with skull base chordomas presenting by the age of 18 years to the Children’s Hospital of Pittsburgh or the University of Pittsburgh Medical Center from 2004 to 2019. Clinical outcomes, the number and location of recurrences, and progression-free survival time were determined.RESULTSTwenty patients met the study criteria. The most common presenting complaints were diplopia (n = 7), headache (n = 6), and swallowing difficulty (n = 4). Three cases were incidentally discovered. Twelve patients underwent single-stage EEA alone, 2 patients had two-stage EEA, and 6 patients had combined EEA with open far-lateral or extreme-lateral approaches. Fourteen patients underwent gross-total resection (GTR), and 6 patients had near-total resection. Larger tumors were more likely to require staging or a combined approach (86% vs 7%) and were less likely to receive GTR (33% vs 86%) but had comparable recurrence and mortality rates. Five patients developed CSF leaks requiring reoperation, 2 patients developed a permanent abducens nerve palsy, 1 patient suffered an internal carotid artery injury, 1 patient developed an epidural hematoma, and 1 patient developed a subdural empyema. Four (20%) patients had recurrence during follow-up (mean radiographic follow-up 59 months and mean time to local recurrence 19 months). Two patients with recurrence underwent further resection, and 1 patient elected to stop treatment. Both patients who underwent repeat resection experienced a second recurrence, one of whom elected to stop treatment. Both patients who died had an elevated Ki-67 (p = 0.039), one of whom developed de-differentiated histology. A third patient died of progressive spinal metastases without local recurrence and is one of 2 patients who developed postoperative spinal metastases. Both patients whose tumors became de-differentiated progressed from tumors with an initial Ki-67 of 15 or greater (p = 0.035) and received prior radiotherapy to the bulk tumor (p = 0.03).CONCLUSIONSThe majority of pediatric skull base chordomas, when managed at a specialized center with a goal of GTR, may have a better outcome than traditionally believed. Elevated Ki-67 rates may predict poor outcome and progression to de-differentiation.
Predicting nonroutine discharge in patients undergoing surgery for vertebral column tumors
Authors: Ehresman Jeff , Pennington Zach , Feghali James , Schilling Andrew , Hersh Andrew , Hung Bethany , Lubelski Daniel , Sciubba Daniel M. 
Published: November 2020

OBJECTIVEMore than 8000 patients are treated annually for vertebral column tumors, of whom roughly two-thirds will be discharged to an inpatient facility (nonroutine discharge). Nonroutine discharge is associated with increased care costs as well as delays in discharge and poorer patient outcomes. In this study, the authors sought to develop a prediction model of nonroutine discharge in the population of vertebral column tumor patients.METHODSPatients treated for primary or metastatic vertebral column tumors at a single comprehensive cancer center were identified for inclusion. Data were gathered regarding surgical procedure, patient demographics, insurance status, and medical comorbidities. Frailty was assessed using the modified 5-item Frailty Index (mFI-5) and medical complexity was assessed using the modified Charlson Comorbidity Index (mCCI). Multivariable logistic regression was used to identify independent predictors of nonroutine discharge, and multivariable linear regression was used to identify predictors of prolonged length of stay (LOS). The discharge model was internally validated using 1000 bootstrapped samples.RESULTSThe authors identified 350 patients (mean age 57.0 ± 13.6 years, 53.1% male, and 67.1% treated for metastatic vs primary disease). Significant predictors of prolonged LOS included higher mCCI score (β = 0.74; p = 0.026), higher serum absolute neutrophil count (β = 0.35; p = 0.001), lower hematocrit (β = −0.34; p = 0.001), use of a staged operation (β = 4.99; p < 0.001), occurrence of postoperative pulmonary embolism (β = 3.93; p = 0.004), and surgical site infection (β = 9.93; p < 0.001). Significant predictors of nonroutine discharge included emergency admission (OR 3.09; p = 0.001), higher mFI-5 score (OR 1.90; p = 0.001), lower serum albumin level (OR 0.43 per g/dL; p < 0.001), and operations with multiple stages (OR 4.10; p < 0.001). The resulting statistical model was deployed as a web-based calculator (https://jhuspine4.shinyapps.io/Nonroutine_Discharge_Tumor/).CONCLUSIONSThe authors found that nonroutine discharge of patients with surgically treated vertebral column tumors was predicted by emergency admission, increased frailty, lower serum albumin level, and staged surgical procedures. The resulting web-based calculator tool may be useful clinically to aid in discharge planning for spinal oncology patients by preoperatively identifying patients likely to require placement in an inpatient facility postoperatively.
Assessing the unique characteristics associated with surgical treatment of dystrophic lumbar scoliosis secondary to neurofibromatosis type 1: a single-center experience of more than 10 years
Authors: Li Song , Mao Saihu , Du Changzhi , Zhu Zezhang , Shi Benlong , Liu Zhen , Qiao Jun , Qiu Yong 
Published: November 2020

OBJECTIVEDystrophic lumbar scoliosis secondary to neurofibromatosis type 1 (DLS-NF1) may present an atypical, unique curve pattern associated with a high incidence of coronal imbalance and regional kyphosis. Early surgical intervention is complicated and risky but necessary. The present study aimed to assess the unique characteristics associated with the surgical treatment of DLS-NF1.METHODSThirty-nine consecutive patients with DLS-NF1 treated surgically at a mean age of 14.4 ± 3.9 years were retrospectively reviewed. Patients were stratified into three types according to the coronal balance classification: type A (C7 translation < 30 mm), 22 patients; type B (concave C7 translation ≥ 30 mm), 0 patients; and type C (convex C7 translation ≥ 30 mm), 17 patients. Types B and C were considered to be coronal imbalance. The diversity of surgical strategies, the outcomes, and the related complications were analyzed.RESULTSThe posterior-only approach accounted for 79.5% in total; the remaining 20.5% of patients received either additional anterior supplemental bone grafting (12.8%) to strengthen the fixation or convex growth arrest (7.7%) to reduce growth asymmetry. The lower instrumented vertebra (LIV) being L5 accounted for the largest share (41%), followed by L4 and above (35.9%), the sacrum (15.4%), and the pelvis (7.7%). Type C coronal imbalance was found in 23 patients (59%) postoperatively, and the incidence was significantly higher in the preoperative type C group (14/17 type C vs 9/22 type A, p = 0.020). All the patients with postoperative coronal imbalance showed ameliorative transition to type A at the last visit. The rate of screw malposition was 30.5%, including 9.9% breached medially and 20.6% breached laterally, although no serious neurological impairment occurred. The incidence of rod breakage was 16.1% (5/31) and 0% in patients with the posterior-only and combined approaches, respectively. Four revisions with satellite rods and 1 revision with removal of iliac screw for penetration into the hip joint were performed.CONCLUSIONSSurgical strategies for DLS-NF1 were diverse across a range of arthrodesis and surgical approaches, being crucially determined by the location and the severity of dystrophic changes. The LIV being L5 or lower involving the lumbosacral region and pelvis was not rare. Additional posterior satellite rods or supplementary anterior fusion is necessary in cases with insufficient apical screw density. Despite a high incidence of postoperative coronal imbalance, improvement of coronal balance was frequently confirmed during follow-up. Neurological impairment was scarce despite the higher rate of screw malposition.
Divergence in the epidemiological estimates of traumatic brain injury in the United States: comparison of two national databases
Authors: Stopa Brittany M. , Harary Maya , Jhun Ray , Job Arun , Izzy Saef , Smith Timothy R. , Gormley William B. 
Published: November 2020

OBJECTIVE
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in the US, but the true incidence of TBI is unknown.

METHODS
The National Trauma Data Bank National Sample Program (NTDB NSP) was queried for 2007 and 2013, and population-based weighted estimates of TBI-related emergency department (ED) visits, hospitalizations, and deaths were calculated. These data were compared to the 2017 Centers for Disease Control and Prevention (CDC) report on TBI, which used the Healthcare Cost and Utilization Project’s National (“Nationwide” before 2012) Inpatient Sample and National Emergency Department Sample.

RESULTS
In the NTDB NSP the incidence of TBI-related ED visits was 59/100,000 in 2007 and 62/100,000 in 2013. However, in the CDC report there were 534/100,000 in 2007 and 787/100,000 in 2013. The CDC estimate for ED visits was 805% higher in 2007 and 1169% higher in 2013. In the NTDB NSP, the incidence of TBI-related deaths was 5/100,000 in 2007 and 4/100,000 in 2013. In the CDC report, the incidence was 18/100,000 in both years. The CDC estimate for deaths was 260% higher in 2007 and 325% higher in 2013.

CONCLUSIONS
The databases disagreed widely in their weighted estimates of TBI incidence: CDC estimates were consistently higher than NTDB NSP estimates, by an average of 448%. Although such a discrepancy may be intuitive, this is the first study to quantify the magnitude of disagreement between these databases. Given that research, funding, and policy decisions are made based on these estimates, there is a need for a more accurate estimate of the true national incidence of TBI.
提高高中英语写作教学有效性的探究
Authors: 刘 韵 , 欧阳 芳 , 邹 玮宏 , 邹 细梅 
Published: November 2020

《普通高中英语课程标准》对写作提出了更高的要求，其中九级语言技能目标——写作能力的描述如下：1. 能用英文书写摘要、报告、通知和公务信涵等；2. 能比较详细和生动地用英语描述情景、态度或情感；3. 能阐述自己的观点和评述他人的观点，文体恰当，用词准确；4. 能在写作中恰当地处理引用的资料及他人的原话；5. 能填写各种表格，写个人简历和申请书，用语基本正确、得当；6. 能做简单的笔头翻译；7. 能在以上写作过程中做到文字通顺，格式正确。因此，在新课程标准中，写作技能占有极其重要的地位和作用，并对此提出了新的要求。
Desain Sekuen Primer Dan Probe Quantitative Polymerase Chain Reaction Gen Spesifik RLEP Mycobacterium Leprae
Authors: Adhin Asryadin 
Published: November 2020

Kusta merupakan salah satu penyakit menular yang disebabkan oleh Mycobacterium leprae. Diagnosis infeksi penting untuk tujuan studi epidemiologis, penegakan diagnosa serta pemberian terapi pengobatan yang tepat pada pasien terinfeksi. Kusta tahap awal sulit didiagnosis hanya melalui kriteria klinis karena sensitivitas pewarnaan yang cukup rendah. Selain itu, tes serologis berdasarkan antigen M. leprae spesifik tidak mendeteksi semua kasus klinis karena sebagian besar pasien pada tahap infeksi paucibacillary (PB) tidak memberikan tingkat respons antibodi yang signifikan. Pengembangan metode deteksi M. leprae berbasis qPCR dengan target sekuen gen RLEP penting dilakukan sehingga dapat dijadikan alternatif metode deteksi yang lebih baik Dalam penelitian ini, desain sekuen pasangan primer dan probe menggunakan teknologi bioinformatika.Tujuan dari penelitian ini adalah untuk melakukan desain sekuen pasangan primer dan probe untuk pemeriksaan M. leprae berbasis kuantitatif Polymerase Chain Reaction menggunakan sekuen gen RLEP. Desain penelitian adalah deskriptif dengan jenis studi cross sectional. Data yang diperoleh dianalisis secara deskriptif.Hasil penelitian diperoleh : primer forward : 5’-GTGCGGCCACATTGACCA-3’ ’; primer reverse : 3’-GGCTGTGCTGAAGGCGATATC-5’ ’'dengan panjang amplikon 126 pasang basa, dan sekuen probe : 5’-CGCCGACACCTCAAGGCCA-3’. Sekuen pasangan primer dan probe memenuhi syarat untuk q-PCR.