bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiofrequency Ablation Effect on Histo- and Fibroarchitectonics of Plantar Aponeurosis in Dogs with Fasciopathy Simulated by Alprostadil
Authors: Markelova M. V. , Reznik L. B. , Kononov A. V. , Dzyuba G. G. , Silant'ev V. N. , Turushev M. A. , Kuznetsov N. K. 
Published: April 2020

The aim of the study was to investigate radiofrequency ablation (RFA) effect on histo- and fibroarchitectonics of plantar aponeurosis in dogs with fasciopathy simulated by alprostan.Material and methods. Methods of light microscopy (Van Gieson, Weigert–Van Gieson and picro-allory staining with alcian and toluidine blue) and morphometry were used in the study. The study involved sections of plantar aponeurosis in animals of the control group (without fasciopathy, n=8), the main group (with RFA, n=8) and the comparison group (without RFA, n=8).Results. The study demonstrated that a single exposure to RFA after simulated alprostane fasciopathy (four-time injection of the medication during 35 days) did not cause an increase or occurrence of additional pathological changes in the injection area after 7 days. Edema, microbleeding, infiltration by lymphocytes, plasmocytes and leukocytes, dystrophy in the form of mucoid swelling, collapse and rupture of collagen fibers were revealed in animals of the main group, as well as in animals of the comparison group. Processes of adaptation and regeneration of the connective tissue in both groups were manifested in the form of a large number of activated fibrocytes, fibroblasts, microvessels, and the formation of collagen fibers. All these together resulted in the same type of heterochronous and heteromorphic spatial histotopographic changes in the aponeurosis – its structure became more cellular, but less ordered in space. Foci of the chaotic distribution of damaged and newly formed collagen fibers appeared. However, exposure to RFA under moderate power (energy) conditions destroyed cells, thin and damaged collagen fibers, and prevented the development of irreversible fibrinoid swelling and granulation tissue around the foci of dystrophy. Together, all these changes reduced the possibility of gross cicatricial rearrangements in the foci of pathologically altered collagen networks.Conclusion. A single exposure to RFA prevented the development of irreversible stromal-vascular dysproteinoses, inflammatory processes and gross cicatricial changes in the connective tissue of the plantar aponeurosis in dogs. These changes can be determined as reasons for the positive clinical effect of RFA on the foci of pathologically altered collagen networks in fasciopathies.
Age Dependency of Spermatogenesis Efficiency in Cats
Authors: Torgun P. M. , Nikityuk D. B. , Klochkova S. V. , Alexeeva N. T. , Kvaratskheliya A. G. , Sokolov D. A. , Ul'yanov I. A. , Teptsova A. D. , Tkachenko A. S. , Goryainova M. V. 
Published: April 2020

The purpose of this study is to study the efficiency of spermatogenesis in old and young cats in various seasons of the yearMaterial and methods. The material has been collected from 16 cats of different ages in winter and summer periods in Voronezh veterinary clinics while animals being sterilized. The testicles were fixed in Shtiva’s liquid and Buen’s liquid. The material was poured into paraffin and a series of paraffin sections 4–5 μm thick were prepared. Sections were stained with hematoxylin and eosin, iron hematoxylin, Heidengain azane, trichrome-PAS reaction and tetrachrome-PAS reaction. By means of a helical eyepiece-micrometer, the diameter of the testicles tubules and the epididymis (50 measurements for each animal) were measured. To determine the effectiveness of spermatogenesis at an increase in 900 times, the number of first-order spermatocytes in the zigotene and pachitene stage, early spermatid (50 canals for each animal) was estimated. The normality of the distribution was determined using the Kolmogorov–Smirnov test and the Lilliefors adjustment. The measurement results were processed using the nonparametric Mann–Whitney U-criteria. Changes at Р<0.05 were considered statistically significant.Results. The maximum diameter of the testicular tubules and the canal of the epididymis was found in animals at two years of age. These parameters in cats at the age of 8 years are reduced by 29.2%, and by17.0%, respectively. Comparing the number of dying cells in old and young animals, it can be noted that in cats at the age of 8 years the number of dying spermatids increases, while spermatogenesis efficiency decrease is statistically significant (by 19.1%).
Design and Implementation of a Low Power Wind Turbine Emulator Through the Induction Motor-Permanent Magnet Generator Arrangement
Authors: Bajonero-Sandoval David Felipe , Sanabria-Vargas Jeyson , Trujillo-Rodriguez César Leonardo 
Published: April 2020

This paper presents the design and construction stage of a low power wind turbine emulator, which is used at the laboratory level, to reproduce different wind profiles. There are several types of wind emulators, among which the wind tunnel emulators stand out. These emulators use a motor with a propeller on their axis to obtain the desired wind speed. However, in the present work -and done from a computer- speed control is developed for a three-phase induction motor, thus driving a permanent magnet generator. The motor-generator group is controlled through a program developed in the Labview software. Also, it has the particularity of operating automatically, being able to load different speed data. Such data is associated with a particular power that takes into account the selected wind profile and can operate through manual control of the wind speed. However, this depends on the frequency given. The emulator operation is validated experimentally through two scenarios: the first one emulates the curve presented by the Eolos turbine and subsequently compares the results obtained, whereas the second one loads the wind profile of Uribía-Guajira -a region in Colombia- achieving that the emulated wind profile can be accurately seen in the loaded wind profile.
Studi Potensi Ubi-Ubian Spesifik Lokal dan Upaya Pengembangannya Dalam Mendukung Kemandirian Pangan di Provinsi Bengkulu
Authors: Yani Asmah , Rawiniwati Wayan 
Published: April 2020

<p>To support food resilience it is felt necessary to do an inventory of any lokal specific plant is cultivated mainly in the form of crop growers of potatoes in order to develop its potential, because if not preserved such commodities are feared will become extinct and the community remains dependent on food rice. The objective of this research was to know the existence and distribution of potential cassava to support community food resilience in Bengkulu Province, know lokal specific cassava cultivation techniques and how much potential land can be developed to support food resilience in Bengkulu Province. This research was conducted at Regency of Rejang Lebong and Regency of Kepahiang, Province of Bengkulu from January-April 2019. The method of this research were observation approach, (interviews using questionnaires, dept interview and Focus Group Discussion (FGD). The selection of sample location research done by purposive sampling with consideration of the potential growth of the plant tubers. The result showed that in Bengkulu turned out for lokal specific crop potential was sweet potatoes. From 10 countries in Bengkulu, sweet potatoes spread across 7 districts namely Seluma, Mukomuko, Kaur, Central Bengkulu, Kepahiang, Lebong and Rejang Lebong. The potential of land that can be developed for the sweet potato cultivation based on the assumption of the existence of land in location of research there were as many as 6,407.0 ha or 0.33% of the land area of Bengkulu province.</p>
The neutrophil-lymphocyte ratio has a role in predicting the effectiveness of nivolumab in Japanese patients with metastatic renal cell carcinoma: A multi-institutional retrospective study
Authors: Nishiyama Naotaka , Hirobe Megumi , Kikushima Takuya , Matsuki Masahiro , Takahashi Atsushi , Yanase Masahiro , Ichimatsu Keisuke , Egawa Masayuki , Hayashi Norihiro , New Takahito Negishi , Masumori Naoya , Kitamura Hiroshi 
Published: April 2020

Abstract
Background:The neutrophil-lymphocyte ratio (NLR) is a well-known prognostic marker in various cancers. However, its role as a predictive marker for the effectiveness of nivolumab in patients with metastatic RCC (mRCC) remains unclear. We evaluated the relationships between the NLR and progression-free survival (PFS) or overall survival (OS) in mRCC patients treated with nivolumab. Methods: The data of 52 mRCC patients who received nivolumab therapy were collected from seven institutes and evaluated. The median follow-up period from treatment with nivolumab was 25.2 months (IQR 15.5-33.2). Results: The median duration of nivolumab therapy was 7.1 months (IQR 2.9-24.4). The objective response rate was 25% and the 1- and 2-year PFS rates were 46.2% and 25.2%, respectively. The median NLR values at baseline and 4 weeks were 3.7 (IQR 2.7-5.1) and 3.3 (IQR 2.4 -5.7), respectively. In the multivariate analysis, an NLR of ≥ 3 at 4 weeks was an independent predictor of PFS ( P = 0.013) and OS ( P = 0.034). The 1-year PFS of patients with an NLR of < 3 at 4 weeks was better than that of those with an NLR of ≥ 3 (75% versus 29%, P = 0.011). The 1-year OS of patients with an NLR of < 3 at 4 weeks was also better than that of those with an NLR of ≥ 3 (95% versus 71%, P = 0.020). Conclusions: Although the baseline NLR was not associated with PFS or OS, an NLR of ≥3 at 4 weeks after the initiation of therapy might be a robust predictor of poor PFS and OS in mRCC patients undergoing sequential treatment with nivolumab.
Robotic, laparoscopic or open hemihepatectomy for giant liver haemangiomas over 10 cm in diameter
Authors: Hu Minggen , Chen Kuang , Zhang Xuan , Li Chenggang , Song Dongda , Liu Rong 
Published: April 2020

Abstract
Abstract

Background
To evaluate the clinical efficacy of robotic, laparoscopic, and open hemihepatectomy for giant liver hemangiomas.Methods

From April 2011 to April 2017, consecutive patients who underwent hemihepatectomy for giant liver haemangiomas were included into this study. According to the type of operation, these patients were divided into the robotic hemihepatectomy (RH) group, the laparoscopic hemihepatectomy (LH) group, and the open hemihepatectomy (OH) group. The perioperative and short-term postoperative outcomes were compared among the three groups. The study was reported following the STROCSS criteria.Results

There were no significant differences in age, sex, tumor location, body surface area (BSA), future liver remnant volume (FLR), standard liver volume (SLV), liver hemangioma volume, FLR/SLV, resected normal liver volume / resected volume, hepatic disease, rates of blood transfusion, liver function after 24 hours of surgery, operative morbidity and mortality among the three groups. Compared with patients in the RH group (n=19), and the LH group (n=13), patients in the OH group (n=25) had significantly longer postoperative hospital stay (P< 0.05), time to oral intake (P < 0.05), time to get-out-of-bed (P < 0.05), a higher VAS score after 24 hours of surgery (P < 0.05) and a shorter operative time (P < 0.05). There were no significant differences in these postoperative outcomes (P>0.05) between the RH group and the LH group. When the setup time in the RH group was excluded, the operative time of the RH group was significantly shorter than the LH group (P<0.05). There was no significant difference in the operative time between the RH group and the OH group (P>0.05). The intraoperative blood loss of the RH group was the least among the three groups (P<0.05) and the intraoperative blood loss of the LH group was less than the OH group (P<0.05).Discussion

Robotic, laparoscopic, and open hemihepatectomy were safe and efficacious treatments for giant liver hemangiomas. Robotic and laparoscopic hemihepatectomy were significantly better than open hemihepatectomy in intraoperative blood loss, postoperative recovery and pain score. Compared with laparoscopic hemihepatectomy, robotic hemihepatectomy was associated with significantly less intraoperative blood loss and shorter operative time.
Potential Impacts of the 2017 American College of Cardiology / American Heart Association High Blood Pressure Guideline on Chinese Adults and How to Address Them
Authors: Jiao Yundi , Sun Zhaoqing , Xie Yanxia , Zheng Jia , Li Zhao , Guo Xiaofan , Dai Yue , Zheng Liqiang , Sun Yingxian 
Published: April 2020

Abstract
Background: The current analysis was performed to estimate the percentage and number of Chinese adults with hypertension and the percentage and number of Chinese adults recommended to receive pharmacological antihypertensive treatment according to the 2017 American College of Cardiology / American Heart Association (ACC/AHA) guideline compared with the same parameters according to the 2010 Chinese guideline.
Methods: We use2011 data from the China Health and Nutrition Survey (CHNS). A total of 12,499 Chinese adults aged ≥ 18 years with complete blood pressure (BP) values were selected for the present analysis.
Results: The crude prevalence rates (95% CI) of hypertension according to the definitions from the 2017 ACC/AHA guideline and the 2010 Chinese guideline were 58.0% (57.2% to 58.9%) and 25.4% (24.7% to 26.2%), respectively. Moreover, the percentage of the participants recommended to take antihypertensive medications were 31.5% and 28.8%, respectively. Among adults who took antihypertensive medications, 88.8% had above-goal BP levels compared to 53.3%. Overall, 613.3 million Chinese adults (aged ≥ 18 years) met the criteria for hypertension according to the 2017 ACC/AHA guideline, and 267.7 million met the criteria according to 2010 Chinese guideline. An additional 28.4 million (2.7%) Chinese adults were recommended to take antihypertensive medication.
Conclusions: The present analysis revealed that the 2017 ACC/AHA hypertension guideline will result in a substantial increase in the percentage and number of Chinese adults defined as having hypertension and a small increase in the percentage of adults who are recommended to take antihypertensive medications compared to the same parameters based on the 2010 Chinese guideline. More intensive management and antihypertensive medications use are suggested to improve the control rate of hypertension among Chinese adults.
Decision-to-delivery interval of emergency cesarean section in Uganda: a retrospective cohort study
Authors: Hughes Noemi , Namagembe Imelda , Nakimuli Annettee , Sekikubo Musa , Moffett Ashley , Patient Charlotte , Aiken Catherine 
Published: April 2020

Abstract
Background : In many low and medium human development index countries, the rate of maternal and neonatal morbidity and mortality is high. One factor which may influence this is the decision-to-delivery interval of emergency cesarean section. We aimed to investigate the maternal risk factors, indications and decision-to-delivery interval of emergency cesarean section in a large, under-resourced obstetric setting in Uganda. Methods: Records of 344 singleton pregnancies delivered at ≥24 weeks throughout June 2017 at Mulago National Referral Hospital were analysed using Cox proportional hazards models and multivariate logistic regression models. Results : An emergency cesarean section was performed every 104 minutes and the median decision-to-delivery interval was 5.5 hours. Longer interval was associated with preeclampsia and premature rupture of membranes/oligohydramnios. Fetal distress was associated with a shorter interval (p<0.001). There was no association between decision-to-delivery interval and adverse perinatal outcomes (p>0.05). Mothers waited on average 6 hours longer for deliveries between 00:00-08:00 compared to those between 12:00-20:00 (p<0.01). The risk of perinatal death was higher in neonates where the decision to deliver was made between 20:00-02:00 compared to 08:00-12:00 (p<0.01). Conclusion : In this setting, the average decision-to-delivery interval is longer than targets adopted in high development index countries. Decision-to-delivery interval varies diurnally, with decisions and deliveries made at night carrying a higher risk of adverse perinatal outcomes. This suggests a need for targeting the improvement of service provision overnight.
LncRNA regulates tomato fruit cracking by coordinating gene expression via a hormone-redox-cell wall network
Authors: Xue Lingzi , Sun Mintao , Wu Zhen , Yu Lu , Yu Qinghui , Tang Yaping , Jiang Fangling 
Published: April 2020

Abstract
Background Fruit cracking occurs easily under unsuitable environmental conditions and is one of the main types of damage that occurs in fruit production. It is widely accepted that plants have developed defence mechanisms and regulatory networks that respond to abiotic stress, which involves perceiving, integrating and responding to stress signals by modulating the expression of related genes. Fruit cracking is also a physiological disease caused by abiotic stress. It has been reported that a single or several genes may regulate fruit cracking. However, almost none of these reports have involved cracking regulatory networks. Results Here, RNA expression in 0 h, 8 h and 30 h saturated irrigation-treated fruits from two contrasting tomato genotypes, ‘LA1698’ (cracking-resistant, CR) and ‘LA2683’ (cracking-susceptible, CS), was analysed by mRNA and lncRNA sequencing. The GO pathways of the differentially expressed mRNAs were mainly enriched in the ‘hormone metabolic process’, ‘cell wall organization’, ‘oxidoreductase activity’ and ‘catalytic activity’ categories. According to the gene expression analysis, significantly differentially expressed genes included Solyc02g080530.3 ( Peroxide, POD ), Solyc01g008710.3 ( Mannan endo-1,4-beta-mannosidase, MAN ), Solyc08g077910.3 ( Expanded, EXP ), Solyc09g075330.3 ( Pectinesterase , PE ), Solyc07g055990.3 ( Xyloglucan endotransglucosylase-hydrolase 7, XTH7 ), Solyc12g011030.2 ( X yloglucan endotransglucosylase-hydrolase 9 , XTH9 ), Solyc10g080210.2 ( Polygalacturonase-2, PG2 ), Solyc08g081010.2 ( Gamma-glutamylcysteine synthetase, gamma-GCS ), Solyc09g008720.2 ( Ethylene receptor , ER ), Solyc11g042560.2 ( Ethylene-responsive transcription factor 4, ERF4 ) etc. In addition, the lncRNAs (XLOC_16662 and XLOC_033910, etc) regulated the expression of their neighbouring genes, and genes related to tomato cracking were selected to construct a lncRNA-mRNA network influencing tomato cracking. Conclusions This study provides insight into the responsive network for water-induced cracking in tomato fruit. Specifically, lncRNAs regulate the hormone-redox-cell wall network, including plant hormone (auxin, ethylene) and ROS (H 2 O 2 ) signal transduction and many cell wall-related mRNAs ( EXP, PG, XTH ), as well as some lncRNAs ( XLOC_16662 and XLOC_033910, etc.).
Assessment of malaria as a public health problem in and around Arjo Didhessa Sugar Cane Plantation area, Western Ethiopia
Authors: Dufera Mebrate , Debsu Regea , Tiruneh Gemechu 
Published: April 2020

Abstract
Background: Although much progress has been made in reducing malaria morbidity and mortality worldwide in the last decade, nationally malaria still remains the third leading cause of death and still considered as major public health problem. Therefore, this study was aimed to assess malaria as a public health problem in and around sugar cane plantation area of Arjo Didhessa sugar factory, Western Ethiopia. Methods: A community based cross sectional study supplemented with clinical retrospective data, which included 452 study subjects was recruited and the study period was extended from May 2016 up to November of 2017. A standardized questionnaire was used to assess malaria risk factors and blood samples were received from all study participants and further subjected to Giemsa staining for determination of malaria prevalence. Data were analyzed by SPSS version 20.Malaria risk factors were identified by multivariate logistic regression at significance level of P < 0.05 . Results: The overall malaria prevalence was 3.1%; Plasmodium vivax being the main type of malaria parasite. Overnight outdoor sleeping and improper utilization of mosquito bed nets were found to be statistically significant as malaria risk factors in the community. In the retrospective studies of five years, the peak malaria cases (13.84%) were reported in 2013 and lowest cases (1.24%) in 2017. Conclusions: The figure of malaria witnessed in this area remains higher than the observed national malaria prevalence indicating malaria is still remains a public health problem.Therefore, we suggest the factory administrators and health care professionals to work more on raising awareness to avoid night outdoor sleeping and effective and appropriate utilization of insecticide treated nets and regular indoor residual spraying. Key words : Arjo Didhessa, malaria, malaria risk factors
The clinical significance of IL-6s and IL-27s in Bronchoalveolar lavage fluids from children with mycoplasma pneumoniae pneumonia
Authors: Zhao Jie , Li Yuyun , Zhang Wen 
Published: April 2020

Abstract
Backgrounds: IL-6 is associated with the severity of mycoplasma pneumoniae pneumonia (MPP). But the relationship between IL-27 and MPP was unknown. Methods: 98 patients with MPP < 14 years old were enrolled in this study and divided into groups by severity (mild cases and severe cases), infection types (MP single infection group and MP mixed infection group) and DNA loads (low MP DNA loads group and high MP DNA loads group), respectively. 15 children with foreign bodies in bronchus were also enrolled as control. IL-6s and IL-27s in bronchoalveolar lavage fluids (BALFs) from these children were measured by ELISA. Results: There were significant differences in IL-6s of BALFs from patients between mild cases and severe cases, MP single infection group and MP mixed infection group, and low MP DNA loads group and high MP DNA loads group, respectively (P﹤0.05). Compared with IL-6s of BALFs from control, IL-6 in BALFs from the 6 patient groups were significantly higher (P﹤0.05). IL-27s in BALFs from MP mixed infection group were significantly lower than those from MP single infection group and control (P﹤0.05) respectively. Conclusion: IL-6 was firmly associated with MPP and had potential application in clinical practice while IL-27 was not related to MP infection.