bluuebunny/crossref_metadata_2025_split huggingface dataset:
Корреляция состава микробиоты полости рта и концентрации секреторного IgA в смешанной слюне у здоровых людей и пациентов с периимплантитом
Authors: Бурлакова Л.А. , Гизингер О.А. , Мураев А.А. , Делидова Е.В. , Иванов С.Ю. , Дымников А.Б. 
Published: December 2024

Представлено исследование микробиоты полости рта методом метагеномного секвенирования 16s рРНК с учетом содержания секреторного иммуноглобулина A (sIgA). Цель исследования — оценка корреляции результатов, полученных методом секвенирования 16s рРНК, с онцентрацией sIgA в слюне. Обследовали 18 пациентов с периимплантитом в возрасте от 18 до 80 лет и 18 людей с имплантатами в полости рта без патологических изменений. Концентрации sIgA в смешанной слюне здоровых людей (1,1 г/л) и у пациентов с периимплантитом (0,52 г/л) достоверно отличаются. При периимплантите в микробиоме полости рта преобладают Haemophilus parainfluenzae (9,3%), Fusobacterium nucleatum (4,8%) Porphyromonas gingivalis (3,3%), Veillonella dispar/parvula (9,4%), Haemophilus haemolyticus/influenzae (1,5%). Выявлена прямая корреляционная связь между содержанием sIgA в слюне и разнообразием микроорганизмов в ротовой полости у обследованных.
A study of oral microbiota through 16S rRNA metagenomic sequencing and secretory immunoglobulin A (sIgA) was conducted. The aim of the study was to evaluate the correlation between the results obtained by 16S rRNA sequencing method and the level of sIgA. . The study involved saliva from 18 patients with peri-implantitis aged between 18 and 80 years and 18 individuals with oral implants without pathological changes. . The level of secretory IgA in healthy individuals (1.1 g/L) and in patients with peri-implantitis (0.52 g/L) significantly differs. In peri-implantitis, the following types of bacteria predominate in the oral microbiome: Haemophilus parainfluenzae (9.3%), Fusobacterium nucleatum (4.8%), Porphyromonas gingivalis (3.3%), Veillonella dispar/parvula (9.4%), Haemophilus haemolyticus/influenzae (1.5%). . A direct correlation has been identified between the level of sIgA in saliva and the diversity of microorganisms in the oral cavity of the subjects examined.
Simulating Gravitational Microlensing Events by TESS: Predictions on Statistics and Properties
Authors: Sajadian Sedighe , Kalantari Atousa , Fatheddin Hossein , Khakpash Somayeh 
Published: December 2024

Abstract
We study the statistics and properties of microlensing events that can be detected by the Transiting Exoplanet Survey Satellite (TESS) based on Monte Carlo simulations. We simulate potential microlensing events from a sample of TESS Candidate Target List (CTL) stars by assuming different observational time spans (or different numbers of sectors for each star) and a wide range of lens masses, i.e., M
l ∈ [0.1 M
⊕, 2 M
⊙]. On average, the microlensing optical depth and the event rate for CTL stars are ≃0.2 × 10−9 and ΓTESS ≃ 0.6 × 10−9 star–1 day–1, respectively. The microlensing optical depth decreases with increasing CTL priority, whereas the efficiency for detecting their microlensing signals enhances with priority. Additionally, we simulate microlensing events from TESS Full Frame Image (FFI) stars extracted from the TESS-SPOC pipeline. The optical depth and event rate for these stars are on average ≃1–3 × 10−9, and ΓTESS ≃ 1–4 × 10−9 star–1 day–1, and their highest values occur for Sector 12. The total number of microlensing events for the CTL stars is N
e,tot ∼ 0.03, whereas for the FFI stars the number of events per star during the 27.4 day observing windows is

N

ˆ

e
,
tot

≃
1.4
×

10

−
6

. Based on four criteria we extract the detectable microlensing events and evaluate the detection efficiencies. The highest efficiency for detecting microlensing events from the TESS data occurs for lens masses of

log

10

[

M

l

(

M

⊙

)
]
∈
[
−
4.5

, −2.5], i.e., super-Earths to Jupiter-mass free floating planets. The detectable microlensing events from the TESS stars are significantly affected by both finite-source and parallax effects.
Preparing for the Early eVolution Explorer: Characterizing the Photochemical Inputs and Transit Detection Efficiencies of Young Planets Using Multiwavelength Flare Observations by TESS and Swift
Authors: Howard Ward S. , MacGregor Meredith A. , Feinstein Adina D. , Vega Laura D. , Cody Ann Marie , Turner Neal J. , Scott Valerie J. , Burt Jennifer A. , Venuti Laura 
Published: December 2024

Abstract
Ultraviolet flare emission can drive photochemistry in exoplanet atmospheres and even serve as the primary source of uncertainty in atmospheric retrievals. Additionally, flare energy budgets are not well understood due to a paucity of simultaneous observations. We present new near-UV (NUV) and optical observations of flares from three M dwarfs obtained at 20 s cadence with Swift and the Transiting Exoplanet Survey Satellite (TESS), along with a reanalysis of flares from two M dwarfs in order to explore the energy budget and timing of flares at NUV-optical wavelengths. We find a 9000 K blackbody underestimates the NUV flux by ≥2× for 54 ± 14% of flares and 14.8× for one flare. We report time lags between the bands of 0.5–6.6 minutes and develop a method to predict the qualitative flare shape and time lag to 36% ± 30% accuracy. The scatter present in optical-NUV relations is reduced by a factor of 2.0 ± 0.6 when comparing the total NUV energy with the TESS energy during the FWHM duration due to the exclusion of the T
eff ≈ 5000 K tail. We show the NUV light curve can be used to remove flares from the optical light curve and consistently detect planets with 20% smaller transits than is possible without flare detrending. Finally, we demonstrate a 10× increase in the literature number of multiwavelength flares with the Early eVolution Explorer (EVE), an astrophysics Small Explorer concept to observe young clusters with simultaneous NUV and optical bands in order to detect young planets, assess their photochemical radiation environments, and observe accretion.
The Trial
Authors: Sloan Victor S. , Wingerson Lois , Adams Christopher 
Published: December 2024

Mrs. Ellis (a pseudonym) is a 57-year-old woman with a 10-year history of rheumatoid arthritis (RA) and a previous episode of transverse myelitis with residual pain and weakness.After the patient's insufficient response to methotrexate (MTX) and upon realizing that tumor necrosis factor inhibitors are relatively contraindicated in demyelinating disease, I wrote a prescription for abatacept (ABA), which could conceivably help both her RA and her transverse myelitis.
La Création chymique. L’exégèse newtonienne de la Genèse selon la correspondance avec Burnet (1680-1681)
Authors: Mathieu Frédéric 
Published: December 2024

Dans une lettre adressée au théologien Thomas Burnet au début de la décennie 1680, Newton avance une interprétation de la Genèse biblique emblématique du genre des « théories de la Terre ». Partant du postulat que la narration de Moïse est un récit « accommodé », adapté au vulgaire, il se persuade que son contenu « philosophique » peut être restauré à l’aune des connaissances modernes. Loin d’adopter un paradigme strictement mécaniste, Newton propose alors une exégèse chymique de la Création. Le Système du monde, le Soleil, la Terre et ses reliefs se seraient formés au gré d’une succession de séparations et de coagulations à partir d’un « Chaos commun ». Les mers et les montagnes seraient issues de la coagulation irrégulière de la parcelle de Chaos assignée à notre planète à la manière dont coagule une solution de salpêtre. Le texte est émaillé d’analogies chymiques, et chaque opération accomplie dans le temps de la Création trouve sa contrepartie dans le laboratoire. Toutes les transformations du Chaos primordial sont effectuées par une force formatrice qui joue à grande échelle le rôle que les alchimistes attribuaient aux ferments. Cette force est la gravitation, que la lettre de Newton associe à l’esprit de Dieu. La reconstitution de Newton présente sous ce rapport des traits communs avec les traités chrysopoétiques qui développent l’analogie entre le Magistère et la Genèse. Le philosophe ne s’était pas contenté de prendre connaissance de ce courant d’interprétation chymique ou alchimique de la Genèse. Il avait composé lui-même des commentaires autour de ces lectures dans une période proche de la lettre à Burnet.
Sur les traces des pourceaulx de Jaquet Jamoy
Authors: Glinel Charlotte 
Published: December 2024

Jaquet Jamoy est l’un des rares personnages que l’on peut rencontrer à plusieurs reprises dans les registres de la juridiction de l’abbaye de Saint-Germain-des-Prés au début du xve siècle, grâce aux nombreuses interpellations dont il fait l’objet. Appuyé sur une enquête archivistique portant sur la gestion des déchets parisiens, attentive aux sensibilités et à leur signification sociale, le récit suit les traces des porcs du tripier multirécidiviste, des tas de fumier aux chambres de ses voisins bouchers. Ce parcours amène à saisir les tenants de la perception de la pollution urbaine dans un contexte politique constructeur d’une norme environnementale urbaine guidée par les sens.
Légitimités territoriales à Makili : négociations coutumières et alliance matrimoniale
Authors: Facal Gabriel 
Published: December 2024

À Makili, sur lʼîle d’Atauro (Timor-Est), la légitimité des clans à occuper leurs territoires est ancrée dans des récits de fondation qui relatent des métamorphoses et des déplacements à travers la région. Ces récits d’origine, encore aujourd’hui, conditionnent l’accès aux ressources locales (eau, terres cultivables, bambous, produits de la mer, etc.) et servent de preuve d’autochtonie. Le territoire est également structuré par des alliances matrimoniales, selon une dynamique double. D’une part, une dynamique externe : les mariages sont interdits au sein d’un même clan, sans qu’il existe de règle préférentielle entre clans. D’autre part, une dynamique interne : la formation et la subdivision des clans et de leurs maisons coutumières dépendent de l’échange de biens (belis) lors des alliances. Ces échanges permettent de régler des dettes envers les ancêtres et entre les clans, au fil des générations. Cette institution de l’échange, marquée par une compétition entre clans, assure la stabilité politique et la souveraineté territoriale.
Assessment of Antibiotics Adherence and Investigating the Targeted Interventions to Dwindle the Antibiotics Nonadherence
Authors: Kothandan Dhivya , Keshavini S. , Jagadheeshwari M. , Ramya V. G. Sapthami , Backkiyashree D. , Pratibha N. , Sophia B. Vincy Santhana , Ramya A. 
Published: December 2024

Introduction:
Antibiotic resistance is a pressing global health concern, exacerbated by antibiotic nonadherence and misuse. Understanding the knowledge, attitude, and practice (KAP) regarding antibiotics among the general population is crucial for effective interventions. This study aims to assess antibiotic adherence behavior among adults in the Chennai population and validate potential interventions to improve adherence.

Materials and Methods:
This cross-sectional study was conducted in and around Thoraipakkam, Chennai, over 6 months. Data were collected using a specially designed form covering demographics, medication adherence, KAP related to antibiotics. Statistical analysis was performed using SPSS version 23.

Results:
Among 250 participants, the majority (64%) was nonadherent to antibiotics, with significant associations found between adherence and gender, education, and medication purchase practices. Knowledge scores indicated that 39% had good knowledge of antibiotic use. Attitudes were varied, with 56% holding positive attitudes toward antibiotics. Practices also varied, with 52% exhibiting good antibiotic use practices. Validation of potential interventions showed high acceptance rates among participants, indicating the effectiveness of targeted interventions in improving adherence.

Conclusion:
This study highlights the prevalence of antibiotic nonadherence and identifies factors associated with it among adults in Chennai. It underscores the importance of targeted interventions to improve adherence and mitigate antibiotic resistance.
A Survey on Quality of Services, Training, and Attitude of Dermatology Trainee Residents About Sexually Transmitted Infections in Teaching Hospitals Across India
Authors: Mehta Nikhil , Agrawal Sushant , Kaur Japnoor , Gupta Somesh 
Published: December 2024

Abstract

Introduction:
The incidence of sexually transmitted infections (STIs) has increased disproportionately to STI services. It is uncertain how many residents trained in STI services continue them. This study assessed the self-rated quality of training and attitudes about STI services amongst residents of Indian teaching hospitals.

Materials and Methods:
In this descriptive cross-sectional survey study, opinions from Indian postgraduate trainee residents were sought in three domains of STIs- institutional STI management practices, quality and satisfaction with training, and attitude towards STI services.

Results:
A total of 225 responses were included. There was no separate area for STI services at centers of 51.6% of residents, and among those with separate STI posting, the duration was ≤2 months for 34.7%, with 59.6% wishing for its increase. Easily available bedside tests were used regularly when indicated by only 41.8%. Only 58.2% of respondents strictly ensured contact tracing and partner treatment. Only 65.8% of centers had provision of benzathine penicillin. Under-confidence in managing STIs independently was reported by 19.6%. Inadequate training was the second reason for wishing to discontinue STI services upon completion of training; with 71.5% wishing to continue STI practice. In univariate analysis, frequent point-of-care testing (P < 0.001), and >2 months of separate STI posting (P = 0.018) were associated with good satisfaction with STI training. Frequent point-of-care testing (P < 0.001), and male gender (P < 0.001) were associated with good confidence in independently managing STIs. Male gender (P = 0.038), having less reluctance in dealing with STI patients (P = 0.003), and good confidence in independently managing STIs (P = 0.008), was associated with willingness to continue STI practice.

Conclusions:
STI care is associated with reluctance. Current STI training in Indian teaching hospitals is less than desired and can lead to unwillingness amongst residents to practice STI services in the future. Having >2 months of separate STI posting, frequent point-of-care tests, and efforts to reduce reluctance when dealing with STI patients are steps that can improve the STI training experience of residents.
Clinical and Laboratory Parameters of Metabolic Syndrome in Chronic Spontaneous Urticaria: A Cross-Sectional Study
Authors: Reddy M. Thanoj K. , Kolalapudi Seetharam A. , Praveen Seva , Konala Subhashini , Rasajna Gunnam L. , Khutate Saloni S. 
Published: December 2024

Abstract

Background:
Chronic spontaneous urticaria (CSU) appears to share some pathomechanisms with metabolic syndrome (MS), such as proinflammatory state, increased oxidative stress, changes in adipokine profile, and coagulation system activation.

Aim and Objectives:
To evaluate clinical and laboratory parameters of MS in CSU patients and to assess relationship of MS with duration and severity of CSU, Ig-E, thyroid-stimulating hormone (TSH), C-reactive protein (CRP), and autologous serum skin test (ASST).

Materials and Methods:
A hospital-based cross-sectional study was conducted on 131 CSU cases and 131 controls who were age- and sex-matched. Duration of the CSU and urticaria activity score (UAS) were noted. Waist circumference (WC), blood pressure, fasting blood sugar, high-density lipoprotein (HDL), triglycerides (TG), CRP, TSH, IgE, and ASST were noted. MS was considered according to Harmonization Asian criteria.

Results:
The percentage of patients with elevated clinical and laboratory parameters of MS was higher in cases compared to controls, in which WC, HDL, and TG were significantly elevated. MS was positive in 25.19% and 14.50% of cases and controls, respectively (P = 0.044). Cases with MS had a significant higher mean duration (16.60 months) than those without MS (8.81 months) (P = 0.004). MS was positive in 15.2%, 32.3%, and 36.4% of mild, moderate, and severe UAS patients, respectively (P = 0.095). Patients with increased TSH and CRP had a significantly higher percentage of MS (68.4% and 40.7%, respectively) than with normal TSH and CRP (15% and 19.4%, respectively) (P < 0.05), while it was not significant with respect to IgE and ASST.

Limitations:
Small sample size and it was a hospital-based study, therefore, all controls were from the patients attending our outpatient department only and could not be compared with the general population.

Conclusion:
MS is not uncommon in CSU patients. The duration of CSU, CRP levels, and TSH levels have a significant positive correlation with MS. Screening, along with regular surveillance of CSU patients, aids in the early detection of MS and minimizes the risk of cardiovascular disease.
Policy to Expand Accessing Antimalarial Drug Treatment in Papua Region-Indonesia: Who Should Be the Target?
Authors: Yuliasih Yuneu , Ipa Mara , Laksono Agung Dwi , Widayati Anis Nur , Rahayu Nita , Astuti Endang Puji 
Published: December 2024

Summary
The Papua region of Indonesia faces a substantial burden of malaria cases. To broaden the understanding of factors influencing access to antimalarial drug treatment, researchers analyzed the 2018 Indonesia Basic Health Survey data. Their examination encompassed demographics, socioeconomic elements, and transportation expenses. Notably, the study revealed that Papuan malaria patients in West Papua were 1.812 times more likely to receive anti-malarial drug treatment compared to those in Papua Province. In addition, individuals residing in rural areas and those not engaged in farming were more inclined to access treatment. Surprisingly, education level did not correlate with treatment accessibility, while individuals with higher wealth were less likely to receive treatment. Moreover, transportation costs did not pose a barrier to treatment access. The study underscores the importance of targeting specific demographics, including those in Papua Province, urban areas, and nonfarming occupations, to enhance the availability of anti-malarial treatment in the region.
Barriers to Uptake of Cataract Surgery in Central Chhattisgarh
Authors: Chatterjee Samrat , Mohata Nehal , Gangwe Anil Babanrao , Sahu Anupam , Agrawal Deepshikha 
Published: December 2024

Abstract

Background:
Understanding and addressing barriers to cataract surgery is important in increasing cataract surgical coverage. Barriers differ across time and place; therefore, periodic evaluation in the area of operation of an eye care provider is required.

Objectives:
The objective is to enumerate the barriers to cataract surgery in central Chhattisgarh.

Materials and Methods:
A hospital-based cross-sectional study was carried out among community outreach patients with cataract in 2022. Patients were selected through systematic random sampling.

Results:
Of the 2210 patients, 1026 completed the survey. Overall person-related barriers (65.3%) were more common than service-related barriers (34.7%). The different barriers were lack of escort (34.0%), cost of surgery (17.7%), lack of awareness of cataract (9.6%), fear of losing eyesight (6.8%), unfelt need (6.3%), waiting for outreach camp to happen in a close-by location (5.9%), waiting for the cataract to mature (4.6%), do not know where to go (3.9%), busy with work (3.7%), living far from the hospital (1.9%), need not felt - old age (1.7%), blindness is God’s will (1.4%), other health reasons (1.1%), being female (0.8%), and village not connected to the main road/lack of transport (0.6%). Person-related barriers were more common (P < 0.05) in female patients, illiterate patients, and those from a lower socio-economic class. Fear of losing eyesight was the most common barrier in patients who had poor vision following cataract surgery in the other eye.

Conclusion:
Person-related barriers were more common than service-related barriers for accessing eye care services. Important service-related barriers were the cost of surgery and lack of awareness about cataract.
Calamities, the Subsequent School Closure, and Their Impact on Adolescents’ Mental Health
Authors: Paslawar Srilatha K , Kallakuri Sudha , Yatirajula Sandhya Kanaka , Daniel Mercian , Maulik Pallab K 
Published: December 2024

Summary
This article aims to understand the implications of calamities and the resulting school closures on the mental health of adolescents. The impact of calamities, such as natural disasters or pandemics, on school closures and adolescents’ mental health is complex. It is crucial to provide the necessary support, resources, and interventions to help adolescents navigate these challenging times and minimize the long-term impact on their mental well-being.
Recurrent Thyroid Cancer Management
Authors: Zhang Emily S. , Scharpf Joseph 
Published: December 2024

ABSTRACT
This article examines the complexities of managing recurrent thyroid cancer, advocating for a personalized approach supported by multidisciplinary collaboration, and underlining that surgery is reserved for those with structural recurrence. The American Thyroid Association guidelines now utilize a dynamic risk assessment model that moves beyond traditional staging systems to account for therapeutic responses as part of predicting recurrences, including the significance of serum thyroglobulin (Tg) levels. Illustrative case studies underscore the importance of thorough preoperative evaluation and planning with imaging and Tg measurements. The use of intraoperative technology, such as nerve monitoring and parathyroid autofluorescence can also assist in better surgical outcomes. Ultimately, a collaborative approach within a thyroid-specific tumor board is presented as essential for optimizing patient care in complex thyroid cancer cases.
An Institutional Experience of Hematoma Management after Head-and-neck Oncosurgeries
Authors: Dhondge Rajendra , Hussain Mohsina , Shaikh Ahmer Arif A. , Roy Sirshendu , Nagarkar Raj 
Published: December 2024

ABSTRACT

Introduction:
Management of patients with head and neck squamous cell carcinoma mainly consists of controlling the primary tumour and regional cervical nodal metastases if any. Surgical complications lead to increased hospital stay, further surgical interventions and sometimes a fatal outcome. Postoperative neck hematoma is one such potential and dreaded complication of head and neck surgeries leading to infection, airway obstruction, compression of the surrounding structures causing free flap failure or sometimes may even lead to death. Haematoma might arise from any of the unaddressed neck vessels or some major vessels in the primary site which were inadvertently injured.

Aims and Objectives:
Development of a checklist to minimise the incidence of haematoma.

Results:
Between August 2017 to March 2019 out of 548 patients operated and reconstructed with free flap, 24 patients (4.38%) had developed a post-operative haematoma. However, after following our protocol, the incidence of haematoma drastically decreased and out of 1234 patients operated between April 2019 to December 2022 only 14 patients (1.13%) developed haematoma of the neck.

Conclusion:
Though ours is a pilot study, we feel that our protocol is easy to follow, and we have applied it successfully in surgical practice and decreased the incidence of post-operative hematoma. We believe if the same protocol is followed and applied in surgical practice it will be of great help to all head-and-neck surgeons.