bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the Implementation of the SWITCH® School Wellness Intervention and Capacity-Building Process through Multiple Methods
Authors: McLoughlin Gabriella M , Candal Priscila , Vazou Spyridoula , Lee Joey A. , Dzewaltowski David A. , Rosenkranz Richard R. , Lanningham-Foster Lorraine , Gentile Douglas A. , Liechty Laura , Chen Senlin , Welk Gregory J 
Published: December 2020

Abstract
Background: School wellness programming is important for promoting healthy lifestyles and academic achievement in youth; however, research is needed on methods that can help schools implement and sustain such programs on their own. The purpose of this study was to investigate factors within and outside the school environment that influenced school capacity for implementation and potential sustainability of wellness programming. Methods: As part of the School Wellness Integration Targeting Child Health (SWITCH®) intervention, elementary school wellness teams (N = 30) were guided through a capacity-building process focused on promoting the adoption of healthy lifestyle behaviors in students. Data on implementation were collected through three standardized surveys and interviews (pre-mid-post) and a post-implementation interview. Indicators of organizational capacity were assessed using the School Wellness Readiness Assessment (SWRA). Paired t-tests were run to assess changes in implementation (classroom, physical education, and lunchroom settings), capacity, and stakeholder engagement over time. One-way analysis of variance (ANOVA) tests were run to examine how implementation of best practices (low, moderate, high) explained differences in capacity gains. Qualitative data were analyzed through inductive and deductive analysis, following the Consolidated Framework for Implementation Research (CFIR). Results: Paired t-tests showed non-significant increases in school and setting-specific capacity and implementation of SWITCH best practices over time, in addition to a consistent level of engagement from key stakeholders. ANOVA results revealed positive, non-significant variances between implementation group and gains in school capacity (F[2,24] = 1.63; p = .21), class capacity (F[2,24]=0.20 p=.82), lunchroom capacity (F[2,24]=0.29; p=.78), and physical education (F[2,24]=1.45; p=.25). Qualitative data demonstrated that factors within the outer setting (i.e., engaging community partners) facilitated programming. Inner-setting factors (i.e., relationships with administration and staff) influenced implementation. Implementation process themes (e.g., planning, adaptation of resources to meet school capacity/needs, and engaging students as leaders) were cited as key facilitators. Schools discussed factors affecting sustainability, such as school culture and knowledge of school wellness policy. Conclusions: The results from this implementation study document the importance of allowing schools to adapt programming to meet their local needs, and highlight the strengths of measuring multiple implementation outcomes. Increased support is needed for schools regarding the formation and improvement of wellness policies as a means to enhance sustainability over time.
Smartphone-based dispatch of Community First Responders to Out-of-Hospital Cardiac Arrest - Statements from an International Consensus Conference
Authors: Metelmann Camilla , Metelmann Bibiana , Kohnen Dorothea , Brinkrolf Peter , Andelius Linn , Böttiger Bernd W , Burkart Roman , Hahnenkamp Klaus , Krammel Mario , Marks Tore , Müller Michael P , Prasse Stefan , Stieglis Remy , Strickmann Bernd , Thies Karl 
Published: December 2020

Abstract
Background: Over the past decade Smartphone-based activation (SBA) of Community First Responders (CFR) to out-of-hospital cardiac arrests (OHCA) has gained much attention and popularity throughout Europe. Various programmes have been established, and interestingly there are considerable differences in technology, responder spectrum and the degree of integration into the prehospital emergency services. It is unclear whether these dissimilarities affect outcome. This paper reviews the current state in five European countries, reveals similarities and controversies, and presents consensus statements generated in an international conference with the intention to support public decision making on future strategies for SBA of CFR.Methods: In a consensus conference a three-step approach was used: (i) presentation of current research from five European countries; (ii) workshops discussing evidence amongst the audience to generate consensus statements; (iii) anonymous real-time voting applying the modified RAND-UCLA Appropriateness method to adopt or reject the statements. The consensus panel aimed to represent all stakeholders involved in this topic.Results: While 21 of 25 generated statements gained approval, consensus was only found for 5 of them. One statement was rejected but without consensus. Members of the consensus conference confirmed that CFR save lives. They further acknowledged the crucial role of emergency medical control centres and called for nationwide strategies. Conclusions: Members of the consensus conference acknowledged that smartphone-based activation of CFR to OHCA saves lives. The statements generated by the consensus conference may assist the public, healthcare services and governments to utilise these systems to their full potential, and direct the research community towards fields that still need to be addressed.
Serum IGFBP-2 in Systemic Sclerosis as a Protective Factor of Lung Dysfunction
Authors: Guiot Julien , Njock Makon-Sébastien , André Béatrice , Gester Fanny , Henket Monique , Seny Dominique de , Moermans Catherine , Malaise Michel G. , Louis Renaud 
Published: December 2020

Abstract
Background: Systemic sclerosis (SSc) is a rare connective tissue disease associated with rapid evolving interstitial lung disease (SSc-ILD), driving its mortality. Specific biomarkers associated with the progression of this lung disease are highly needed. We aimed to identify specific biomarkers of SSc-ILD to predict the evolution of the disease.Methods: We compared prospectively serum levels of several biomarkers associated with lung fibrosis in SSc patients (n=102), among which SSc-no ILD (n=63) and SSc-ILD (n=39), compared to healthy subjects (HS) (n=39). We also performed a longitudinal study in a subgroup of 28 patients analyzing biomarkers variations and pulmonary function tests over a period of 2 years. Furthermore, we performed in vitro analysis to study the impact of Insulin like Growth Factor Binding Protein (IGFBP)-2 on fibrotic activity of human lung fibroblasts. Results: Serum levels of IGFBP-1, IGFBP-2, interleukin-8 and matrix metallopeptidase-9 were significantly increased in SSc patients compared to HS while IGF-1 and IGFBP-3 were reduced. The variation of IGFBP-2 between baseline and 2-year follow-up was positively correlated with pulmonary function (assessed by carbon monoxide transfer coefficient (KCO)) at 2-year follow-up (r=0.6, p<0.001). Receiver operating characteristic curve analysis enabled us to identify that baseline IGFBP-2<105 ng/ml was associated with a better outcome (low risk to display KCO<70% predicted) at 2-year follow-up (area under the curve=0.75 at 75% sensibility and 68% specificity, p<0.05). In vitro functional study showed that IGFBP-2 significantly reduced fibroblast proliferation and pro-fibrotic activity.Conclusions: We showed for the first time that serum levels of IGFBP-2 might predict the evolution of SSc-ILD. Baseline IGFBP-2 above 105 ng/ml might be a prognostic factor of alveolo-capillary dysfunction.
RNA sequencing identifies transcriptional changes in the rabbit larynx in response to low humidity challenge
Authors: Bailey Taylor W , Santos Andrea Pires dos , Nascimento Naila Cannes do , Xie Shaojun , Thimmapuram Jyothi , Sivasankar M. Preeti , Cox Abigail 
Published: December 2020

Abstract
Background: Voice disorders are a worldwide problem impacting human health, particularly for occupational voice users. Avoidance of surface dehydration is commonly prescribed as a protective factor against the development of dysphonia. The available literature inconclusively supports this practice and a biological mechanism for how surface dehydration of the laryngeal tissue affects voice has not been described. In this study, we used an in vivo male New Zealand white rabbit model to elucidate biological changes based on gene expression within the vocal folds from surface dehydration. Surface dehydration was induced by exposure to low humidity air (18.6% + 4.3%) for 8 hours. Exposure to moderate humidity (43.0% + 4.3%) served as the control condition. Ilumina-based RNA sequencing was performed and used for transcriptome analysis with validation by RT-qPCR. Results: There were 103 statistically significant differentially expressed genes identified through Cuffdiff with 61 genes meeting significance by both false discovery rate and fold change. Functional annotation enrichment and predicted protein interaction mapping showed enrichment of various loci, including cellular stress and inflammatory response, ciliary function, and keratinocyte development. Eight genes were selected for RT-qPCR validation. Matrix metalloproteinase 12 (MMP12) and macrophage cationic peptide 1 (MCP1) were significantly upregulated and an epithelial chloride channel protein (ECCP) was significantly downregulated after surface dehydration by RNA-Seq and RT-qPCR. Suprabasin (SPBN) and zinc activated cationic channel (ZACN) were marginally, but non-significantly down- and upregulated as evidenced by RT-qPCR, respectively. Conclusions: The data together support the notion that surface dehydration induces physiological changes in the vocal folds and justifies targeted analysis to further explore the underlying biology of compensatory fluid/ion flux and inflammatory mediators in response to airway surface dehydration.
Suppressor of Variegation 3-9 Homologue 1 Impairment and Neutrophil-skewed Systemic Inflammation Are Associated with Comorbidities in COPD
Authors: Chen Tzu-Tao , Wu Sheng-Ming , Chen Kuan-Yuan , Tseng Chien-Hua , Ho Shu-Chuan , Chuang Hsiao-Chi , Feng Po-Hao , Liu Wen-Te , Han Chia-Li , Huang Erick Wan-Chun , Yeh Yun-Kai , Lee Kang-Yun 
Published: December 2020

Abstract
BACKGROUND: Systemic manifestations and comorbidities are characteristics of chronic obstructive pulmonary disease (COPD) and are probably due to systemic inflammation. The histone methyltransferase SUV39H1 controls the Th1/Th2 balance. We previously reported that reduced SUV39H1 expression contributed to abnormal inflammation in COPD. Here, we aimed to determine whether impaired SUV39H1 expression in COPD patients associated with neutrophilic/eosinophilic inflammation responses and comorbidities.METHODS: A total of 213 COPD patients and 13 healthy controls were recruited from the Shuang Ho Hospital, Taipei Medical University. SUV39H1 levels in peripheral blood mononuclear cells (PBMCs) from 13 healthy and 30 COPD participants were measured by immunoblotting. We classified the patients into two groups based on low (fold change, FC <0.5) and high SUV39H1 expression (FC ≥0.5) compared to normal controls. Clinical outcomes including neutrophil or eosinophil counts associated with SUV39H1-related inflammation were evaluated by Chi square analyses or Mann-Whitney U test. The correlations between the percentage of neutrophils and number of COPD comorbidities or Charlson Comorbidity Index (CCI) scores were performed by Spearman’s rank analysis. RESULTS: Low SUV39H1 expression group had high neutrophil counts relative to high SUV39H1expression group. In the COPD cohort, the high comorbidity group (≥ 2 comorbidities) had higher counts of whole white blood cell (WBC) and neutrophil, and lower proportion of eosinophil and eosinophil/neutrophil, as compared with low comorbidity group (0 and 1 comorbidities). The quantity of neutrophils was associated with COPD comorbidities (Spearman's r=0.388, p<0.001), but not with CCI scores. We also found that the high comorbidity group had more exacerbations per year compared with low comorbidity group (1.5 vs. 0.9 average exacerbations, p=0.005). However, there were no significant differences between groups with these non-frequent (0-1 exacerbation) and frequent exacerbations per year (>1 exacerbation) in numbers of WBC and proportion of neutrophils, eosinophils or eosinophil/neutrophil. Finally, patients with high comorbidities had lower SUV39H1 levels in their PBMCs than did those with low comorbidities.CONCLUSION: Blood neutrophil counts are associated with comorbidities in COPD patients. Impaired SUV39H1 expression in PBMCs from COPD patients are correlated with neutrophilic inflammation and comorbidities.
Validation of the BATT score for prehospital risk stratification of traumatic haemorrhagic&nbsp;death: Usefulness for tranexamic acid treatment&nbsp;criteria.
Authors: Ageron Francois-Xavier , Coats Timothy J , Darioli Vincent , Roberts Ian 
Published: December 2020

Abstract
Background: Tranexamic acid reduces surgical blood loss and reduces deaths from bleeding in trauma patients. Tranexamic acid must be given urgently, preferably by paramedics at the scene of the injury or in the ambulance. We developed a simple score (Bleeding Audit Triage Trauma score) to predict death from bleeding.Methods: We conducted an external validation of the BATT score using data from the UK Trauma Audit Research Network (TARN) from 1st January 2017 to 31st December 2018. We evaluated the impact of tranexamic acid treatment thresholds in trauma patients.ResultsWe included 104,862 trauma patients with an injury severity score of 9 or above. Tranexamic acid was administered to 9,915 (9%) patients. Of these 5,185 (52%) received prehospital tranexamic acid. The BATT score had good accuracy (Brier score=6%) and good discrimination (C-statistic 0.90; 95% CI 0.89-0.91). Calibration in the large showed no substantial difference between predicted and observed death due to bleeding (1.15% versus 1.16%; P=0.81). Pre-hospital tranexamic acid treatment of trauma patients with a BATT score of 2 or more would avoid 210 bleeding deaths by treating 61,598 patients instead of avoiding 55 deaths by treating 9,915 as currently. ConclusionThe BATT score identifies trauma patient at risk of significant haemorrhage. A score of 2 or more would be an appropriate threshold for pre-hospital tranexamic acid treatment.
WITHDRAWN: LPL/AQP7/GPD2 promotes glycerol metabolism under hypoxia and prevents cardiac dysfunction during ischemia.
Authors: Ishihama Sohta , Yoshida Tatsuya , Yoshida Satoya , Ouchi Noriyuki , Mori Yu , Eguchi Shunsuke , Sakaguchi Teruhiro , Tsuda Takuma , Kato Katsuhiro , Shimizu Yuuki , Ohashi Koji , Bando Yasuko , Yagyu Hiroaki , Wettschureck Nina , Kubota Naoto , Offermanns Stefan , Kadowaki Takashi , MUROHARA TOYOAKI , Takefuji Mikito 
Published: December 2020

Abstract
Fatty acid constitutes a major energy substrate in the heart to fuel contraction under aerobic conditions. Ischemia downregulates fatty acid metabolism to adapt to the limited oxygen supply and makes glucose the preferred substrate. However, the mechanism of the myocardial metabolic shift during ischemia remains unknown. Here, we show that cardiomyocyte secretion of lipoprotein lipase (LPL), a principal enzyme that converts triglycerides to free fatty acids and glycerol, increased during myocardial infarction (MI). Cardiomyocyte-specific LPL deficiency enhanced cardiac dysfunction and apoptosis following MI. Deficiency of aquaporin 7 (AQP7), a glycerol channel in cardiomyocytes, increased the myocardial infarct size and apoptosis in response to ischemia. Ischemic conditions activated glycerol-3-phosphate dehydrogenase 2 (GPD2), which converts glycerol-3-phosphate into dihydroxyacetone phosphate to facilitate ATP synthesis from glycerol. Conversely, GPD2 deficiency exacerbated cardiac dysfunction after acute MI. Together, these results identify that LPL/AQP7/GPD2-mediated glycerol metabolism plays an important role to bridge glucose and lipid metabolism in MI and prevent myocardial ischemia-related damage.
ANALISIS KORELASI KEMAMPUAN MEMAHAMI DENGAN KEMAMPUAN BERARGUMENTASI SISWA MELALUI MODEL PEMBELAJARAN ARGUMENT BASED SCIENCE INQUIRY
Authors: Budiyono Agus 
Published: December 2020

Tujuan penelitian ini adalah untuk mendeskripsikan korelasi kemampuan memahami dengan kemampuan berargumentasi siswa pada materi elastisitas dengan menggunakan model pembelajaran Argument-Based Science Inquiry (ABSI). Metode dalam penelitian ini menggunakan pre-experiment dengan desain The one group pretest-posttest. Penelitian ini menggunakan sampel siswa kelas XI IPA 2 di Madrasah Aliah Negeri Pamekasan 2 Kabupaten Pamekasan Jawa Timur pada semester ganjil tahun pelajaran 2015/2016. Adapun instrumen yang digunakan pada penelitian ini berupa dari tes kemampuan memahami dan tes kemampuan berargumentasi siswa. Data dianalisis menggunakan korelasi product moment. Hasil analisis data diperoleh besar korelasi kemampuan memahami dengan kemampuan berargumentasi siswa sebesar 0,73 dengan taraf signifikansi sebesar 0,01 yang berarti bahwa dalam taraf kepercayaan 95 % kemampuan memahami berhubungan secara signifikan terhadap kemampuan berargumentasi, yaitu memiliki korelasi tinggi. Dengan kata lain kemampuan memahami sangat tinggi pengaruhnya terhadap kemampuan berargumentasi siswa.
TINJAUAN SISTEMATIS: STRATEGIS SCAFFOLDING PADA PEMBELAJARAN MATEMATIKA
Authors: Kusmaryono Imam , Wijayanti Dyana 
Published: December 2020

This scientific article presents the results of a literature review on scaffolding strategies in mathematics education (2015-2020). The literature review was based on 32 scientific publications that met the inclusion criteria and were included in the final analysis with a total sample size of 1368 students (participants). In theory, this literature research aims to provide an empirical picture of the latest literature on the application of scaffolding strategies and analyze teacher-student interaction patterns when scaffolding is implemented in mathematics learning. The results of this literature review indicate that the pattern of teacher-student interaction when scaffolding support follows an approach: one-to-one scaffolding, peer-scaffolding, and computer-based scaffolding. here are three categories of teacher tendencies in providing scaffolding support, namely: cognitive scaffolding, affective scaffolding, and metacognitive scaffolding. The results of the literature review also concluded that the application of scaffolding strategies in mathematics learning was effective in terms of reducing mathematics anxiety, motivating and increasing student achievement
Effectiveness assessment of urban waterlogging mitigation for low impact development in semi-mountainous regions under different storm conditions
Authors: Wang Dong , Fu Xiaoran , Luan Qinghua , Liu Jiahong , Wang Hao , Zhang Shuang 
Published: December 2020

Abstract
To assess the urban waterlogging mitigation effectiveness on low impact development (LID) in semi-mountainous regions, the Storm Water Management Model (SWMM) of a semi-mountainous region combined with GIS was generalized. The SWMM was calibrated and validated through maximum seeper depth of the checkpoints, and various LID scenarios have been designed according to local conditions. The discharge processes of outlets, surface runoff, peak flow and peak time were analyzed in different scenarios. The results show that: all the flow processes of outlets in the LID scenario are gentler than that in the status quo scenario, and the effectiveness of LIDs in semi-mountainous regions are different from that in plain regions because of the slope influence; in semi-mountainous regions, the LID effectiveness on surface runoff reduction decreases with the increase in rainfall return period or the extension of rainfall duration, but remains almost unchanged with the increase in rainfall peak coefficient; the LID effectiveness on control peak flow reduction is not remarkable with the change in rainfall characteristics, and the LID effectiveness on peak time delay is poor. This research can provide decision support for regional small-scale measures of urban waterlogging mitigation and reduction in semi-mountainous regions.
Removal of methylene blue from aqueous solutions by adsorption on amorphous silicon dioxide from rice husks
Authors: Arefieva O. D. , Zemnukhova L. A. , Gorlova V. A. , Tsvetnov M. A. 
Published: December 2020

Abstract
This study shows the effect of conditions on methylene blue sorption from aqueous solutions using amorphous silicon dioxide obtained from rice husk by oxidative roasting with and without pre-treatment with 0.1 M HCl. Adsorption activity for methylene blue increases with increasing pH, reaching its maximum above the point of zero charge. Thermodynamic parameter values (ΔG298 &gt; 0, ΔH &lt; 0, ΔS &gt; 0) indicate that methylene blue adsorption is exothermic and occurs with an increase in molecular mobility in the adsorption layer. The process is described by the Freundlich and Dubinin-Astakhov equations, which indicates that it is determined by both electrostatic interaction with active centers on the surface and the volumetric filling of micropores.
Metabolism-based Drug-drug Interactions in Patients with Chronic Respiratory Diseases: A Review Focusing on Drugs Affecting the Respiratory System
Authors: Baniasadi Shadi 
Published: December 2020

Background:
Chronic respiratory diseases (CRDs) are increasing in prevalence, as reported by the
World Health Organization (WHO). Patients with CRDs usually require co-administration of multiple drugs
due to the complex pathogenic mechanisms of CRDs and the existence of concomitant diseases. Polypharmacy
(co-administration of more than four medications) is the main risk factor of the occurrence of drug-drug interactions
(DDIs) that may lead to reducing treatment efficacy and/or increasing adverse effects.

Methods:
This literature-based review focuses on metabolism-based DDIs, the most prevalent DDIs responsible
for difficulties in therapeutic management in patients with CRDs.

Results:
Clinically relevant metabolism-based DDIs occur between drugs used for the treatment of respiratory
diseases (corticosteroids, orally inhaled bronchodilators, methylxanthines, anti-leukotrienes, antimicrobials, endothelin
receptor antagonists, phosphodiesterase inhibitors, antitussives, and antineoplastic agents) and drugs affecting
cytochrome P450 (CYP) (inducers and inhibitors). Considering alternative therapies, adjusting medication
doses, or monitoring patients during treatment are recommended to prevent the harmful consequences of
these interactions.

Conclusion:
Providing information on clinically relevant interactions of drugs more likely prescribed in daily
practices of physicians is essential to improve patient safety. A list of known metabolism-based interactions of
drugs affecting the respiratory systems should be available for physicians engaged in the treatment of CRDs.