bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Competing Risk Nomogram Predicting Cause-specific Mortality in Patients with Lung Adenosquamous Carcinoma
Authors: Wu Xiao , Yu Wenfeng , Petersen RH , Sheng Hongxu , Wang Yiqing , Lv Wang , Hu Jian 
Published: April 2020

Abstract
Background: Adenosquamous carcinoma (ASC) is an uncommon histological subtype of lung cancer. The purpose of this study was to assess the cumulative incidences of lung cancer-specific mortality (LC-SM) and other cause-specific mortality (OCSM) in lung ASC patients, and construct a corresponding competing risk nomogram for LC-SM. Methods: Data on 2,705 patients with first primary lung ASC histologically diagnosed between 2004 and 2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. The cumulative incidence function (CIF) was utilized to calculate the 3-year and 5-year probabilities of LC-SM and OCSM, and a competing risk model was built. Based on the model, we developed a competing risk nomogram to predict the 3-year and 5-year cumulative probabilities of LC-SM and the corresponding concordance indexes (C-indexes) and calibration curves were derived to assess the model performance. To evaluate the clinical usefulness of the nomogram, decision curve analysis (DCA) was conducted. Furthermore, patients were categorized into three groups according to the tertile values of the nomogram-based scores, and their survival differences were assessed using CIF curves. Results: The 3-year and 5-year cumulative mortalities were 49.6% and 55.8% for LC-SM and 8.2% and 11.8% for OCSM, respectively. In multivariate analysis, increasing age, male sex, no surgery, and advanced T, N and M stages were related to a significantly higher likelihood of LC-SM. The nomogram showed good calibration, and the 3-year and 5-year C-indexes for predicting the probabilities of LC-SM in the validation cohort were both 0.79, which were almost equal to those of the ten-fold cross validation. DCA demonstrated that using the nomogram gained more benefit when the threshold probabilities were set within the ranges of 0.24-0.89 and 0.25-0.91 for 3-year and 5-year LCSM, respectively. In both the training and validation cohorts, the high-risk group had the highest probabilities of LC-SM, followed by the medium-risk and low-risk groups (both P<0.0001). Conclusions: The competing risk nomogram displayed excellent discrimination and calibration for predicting LC-SM. With the aid of this individualized predictive tool, clinicians can more expediently devise appropriate treatment protocols and follow-up schedules.
Global trends of researches on pycho-oncology during 1999-2019: A 21-year bibliometric study based on VOSviewer
Authors: Zhang Chengjiao , Hu Guangfu , Qiu Xiaochun , Pan Lingyi , Wang Cheng 
Published: April 2020

Abstract
BackgroundThe studies on psycho-oncology are growing rapidly, but there were no bibliometric studies regarding psycho-oncology. This study was to explore a bibliometric analysis of psycho-oncology in the past 21 years at a global level.MethodsThe literature was searched in Web of Science (WOS) by using subject terms. VOSviewer software was used for bibliometric analysis of the retrieval results.ResultsThe literature search yielded 1921 papers. After screening process, 968 papers were included, which came from 55 countries/regions, 1,452 organizations and 4,152 authors. The top three countries/regions, organizations and authors ranked by the number of published papers were the United States of America (USA) (286), Germany (143) and Australia (130); the Memorial Sloan-Kettering Cancer Centre (MSKCC) (New York, USA) (34), Newcastle University (Newcastle, Australia) (29) and McGill University (Montreal, Canada) (28); Luigi Grassi (University of Ferrara in Italy) (26), Tatsuo Akechi (Nagoya City University Hospital in Japan) (20) and Anja Mehnert (University of Leipzig in Germany) (18), respectively. Moreover, the 968 papers contained 1,768 author keywords, involved in 300 journals and cited 28,311 references. The top three co-occurrence author keywords, most-involved journals and most-cited references were “Quality-of-life”, “Depression” and “Breast cancer”; Psycho-Oncology, Supportive Care in Cancer and Journal of Psychosocial Oncology; “Zigmond AS, 1983”, “Zabora J, 2001” and “Mitchell AJ, 2011”, respectively.ConclusionsThere was a growing trend in published papers related to psycho-oncology, with the organizations and authors from developed countries leading the field. “Quality-of-life”, “Depression” and “Breast cancer” reflected the most hotspots, and the latest progress can be tracked in Psycho-Oncology.
Skin microvascular vasomotion is synchronous at acupoints of beagle dogs
Authors: zhang tao , Liu Chun , Hu Ge , Mu Xiang 
Published: April 2020

Abstract
Background/purpose: Skin microvessels at acupoints have been documented to be more abundant and well-organized, and the synchronous microvascular vasomotion was detected at acupoints in our previous human study. This present study aimed to characterize the skin microvascular vasomotion at acupoints on the twelve meridians of beagle dogs. Materials and Methods: Two acupoints were selected on each meridian, and exactly located at the rosy red spots by an electrochemical color-appearing method, where the electrical resistance was measured. The skin blood flow at acupoints was recorded by laser Doppler flowmetry (LDF), and microvascular vasomotion was analyzed according to LDF waveforms. Results: The skin electrical resistance at acupoints was significantly lower than that at control non-acupoints. The LDF waveforms at acupoints was sinusoidal, which showed the synchronization of the microvascular vasomotion. The spectral analysis revealed that the vasomotion frequencies at acupoints on the same meridian were identical but not among different meridians, and the frequencies on the twelve main meridians displayed a constant order. Conclusion: The skin microvascular vasomotion is synchronous at acupoints of beagle dogs and has a specific frequency along the meridian, and the electrochemical color-appearing method is a feasible strategy for the precise and visual location of acupoints. The study provides evidence for the universality of synchronous vasomotion of skin microvessels at acupoints and contributes to clarifying the essence of acupoints and their effect mechanism.
Proteomic analysis identified salivary immunoglobulin gamma-3 chain C as a potential biomarker for systemic lupus erythematosus
Authors: Jung Ju-Yang , Nam Jin-Young , Ryu Keun-Sil , Shin Joo-Ho , Lee Sung- Min , Baek Wook-Young , Kim Hyoun-Ah , Suh Chang-Hee 
Published: April 2020

Abstract
Background

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies and systemic inflammatory response. We aimed to characterize the salivary protein components and find biomarkers in patients with SLE.
Methods

The pooled salivary proteins of patients with SLE and healthy controls were subjected to 2-dimensional gel electrophoresis. The spots exhibiting > 2-fold intensity change between SLE and healthy controls were identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis.
Results

The proteomic analysis using 2-dimensional gel electrophoresis and mass spectrometry revealed 10 differentially expressed protein spots, which included immunoglobulin gamma-3 chain C region (IGHG3), immunoglobulin alpha-1 chain C region (IGHA1), protein S100, lactoferrin, leukemia-associated protein 7, and 8-oxoguanine deoxyribonucleic acid glycosylase. The patients with SLE exhibited enhanced salivary IGHG3 (3.9 ± 2.15 pg/mL) and lactoferrin (4.7 ± 1.8 pg/mL) levels than patients with rheumatoid arthritis (1.8 ± 1.01 pg/mL and 3.2 ± 1.6 pg/mL, respectively, p < 0.001 for both) or healthy controls (2.2 ± 1.64 pg/mL and 2.2 ± 1.7 pg/mL, respectively, p < 0.001 for both). The salivary IGHG3 levels correlated with erythrocyte sedimentation rate (r = 0.26, p = 0.01), anti-double-strand deoxyribonucleic acid antibody levels (r = 0.25, p = 0.01), and nephritis (r = 0.28, p = 0.01).
Conclusions

Patients with SLE exhibited elevated salivary IGHG3 and lactoferrin levels, and the salivary IGHG3 levels correlated with disease activity markers of SLE. Salivary IGHG3 may be a promising non-invasive biomarker in SLE.
Metatranscriptomic approach for microbiome characterization and host gene expression evaluation for “Hoja de malvón” disease in Vitis vinifera cv. Malbec
Authors: Paolinelli Marcos , Escoriaza Georgina , Cesari Cecilia , Garcia-Lampasona Sandra , Hernandez-Martinez Rufina 
Published: April 2020

Abstract
Background: Grapevine Trunk Diseases (GTD) threat worldwide wine and table grape production, mainly reducing grape yields and in advanced stages causing the death of diseased vines. A particular GTD of enormous concern in Argentinean vitiviniculture is the complex etiology disease locally known as "Hoja de malvón" (HDM). At least four different fungi are involved in the disease, which complicates the diagnostic and the design of strategies for vineyard management. Similar to Esca grape disease, factors that make this disease difficult to control are the presence of pathogens that not always correlates with disease symptoms or physiological changes in the host. Also the abiotic stress on grapevine seems to favors the disease process. Based on this background, it is essential to have molecular tools that allow for simultaneous explorations of the host immunity status and the microbiome composition. Results: A metatranscriptomic approach was followed and different strategies for microbiome characterization, throughmolecular marker reconstruction or unique kmer counts, were evaluated. Malbec microbiome was mainly represented for Dothideomycetes and Actinobacteria. Higher Basidiomycota/Ascomycota ratio was found in symptomatic (SYM) than in asymptomatic (ASYM) plants, with the Basidiomycota Arrambaria destruens found in higher levels in SYM plants. Besides, from mRNA-derived reads, the host functional status and main microbial functions based on gene expression were evaluated. Stress-tolerance mechanisms were activated on ASYM plants, being spermidine synthesis one of the most important, while from the microbiome side, prokaryotic tricarboxylic acid pathways were the primary differential function in SYM plants. Conclusions: This is a pioneering work for the characterization of multi-kingdom endophytic microbiome in woody tissues of grapevine cv. Malbec. Several microorganisms with negative interaction with GTD pathogens were identified and can be further explored as biological control agents for HDM disease. The integral analysis employed suggests that measuring Basidiomycota/Ascomycota ratio and spermidine-associated gene expression would help to monitor the sanitary status of grapevine and the propensity to develop HDM disease. This study provides a departure point for a better comprehension of HDM disease that can be used as a roadmap for further development of curative practices of GTD.
Anais 3º Workshop de Biomateriais “Fitoterápicos – Multidisciplinaridade e Aplicabilidade Comercial”
Authors: Barbosa Débora de Barros , Weert Daniela Atili Brandini de , Guiotti Aimée Maria , Duque Cristiane , Cintra Luciano Tavares Angelo , Briso André Luiz Fraga 
Published: April 2020

EditorialCaro(a) Leitor(a)Os Programas de Pós-Graduação em Ciência Odontológica e em Odontologia da Faculdade de Odontologia de Araçatuba (FOA) – UNESP teve o prazer de realizar o 3º Workshop de Biomateriais em 29 de novembro de 2019. O tema escolhido para esse Workshop foi “Fitoterápicos – Multidisciplinaridade e Aplicabilidade Comercial”. Os estudos com essa temática têm aumentando exponencialmente nos últimos 5 anos e com estimativas também crescentes até 2023, refletindo a tendência dos consumidores pela preferência de bioprodutos por apresentarem diversos benefícios terapêuticos e baixos efeitos colaterais. Pensando dessa forma, selecionamos para esse Workshop de Biomateriais um time diversificado de pesquisadores experts na área para trazerem o que há de mais atual e com aplicabilidades promissoras para as diversas áreas da Odontologia. O Evento contou com o apoio do Programa CAPES-PrInt UNESP, viabilizando a presença de palestrantes de Portugal, Estados Unidos e Canadá. Alunos também participaram divulgando suas pesquisas na área de Biomateriais.Comissão Organizadora
Anais IV CIOPB - Congresso Interdisciplinar de Odontologia da Paraíba
Authors: Penha Elizandra Silva da , Gomes Lucas Linhares 
Published: April 2020

Prezados congressistas,É com grande satisfação que os discentes do 9º e 8º Período, turmas 2015.2 e 2016.1 do Curso de Odontologia da Universidade Federal de Campina Grande (UFCG) em parceria com a equipe docente do Departamento de Odontologia da Universidade realizaram o IV CIOPB (Congresso Interdisciplinar de Odontologia da Paraíba). O evento foi direcionado para estudantes, profissionais e pós-graduandos da Odontologia e aconteceu durante os dias 7, 8 e 9 de novembro de 2019. Preestabeleceremos uma grade científica na qual foi introduzido palestrantes mestres e doutores, nomes de referência em trabalho de qualidade das mais diversas áreas de concentração da Odontologia, com o objetivo de atualizar os conhecimentos clínico-científicos e divulgar trabalhos que estão em alta. A cada nova edição do congresso buscam-se novos temas que despertem a curiosidade dos congressistas a aprenderem sobre novos assuntos, compartilhando experiências sobre diversos conteúdos, estimulando o desenvolvimento da área.O planejamento da programação científica contou com palestras na área, ministradas por palestrantes reconhecidos e renomados, que compartilharam com os congressistas temas importantes e modernos para odontologia além de novas técnicas. Os congressistas contaram, ainda, com a oportunidade de apresentar e assistir às exposições de diversos trabalhos científicos, na modalidade de painel e apresentação oral na forma de pesquisa científica e relato de caso clínico. Ainda, o evento promoveu minicursos que enriqueceram os conhecimentos dos participantes e, por fim, também contou com uma programação social buscando estreitar os laços de interação entre congressistas e palestrantes. Comissão Organizadora - IV CIOPBCongresso Interdisciplinar de Odontologia da Paraíba - 2019
Neurological disorder in celiac patient after third molars extraction: is there a relation?
Authors: Wastner Bruna da Fonseca , Melzer Rafaela Savio , Parise Guilherme Klein , Dobrowolski Samuel , Stramandinoli-Zanicotti Roberta Targa , Schussel Juliana Lucena , Sassi Laurindo Moacir 
Published: April 2020

Celiac disease is an immune-mediated gluten-dependent systemic disorder characterized by a specific profile associated with small intestinal lesion. Some of the classical symptoms observed in patients with this condition are nutrient malabsorption, diarrhea, abdominal pain, fatigue and, more recently, neurological symptoms were associated with the disease. Therefore, the objective is to inform an unusual case of a patient with celiac disease that developed severe permanent paresthesia in the superior and inferior gingiva, tongue and palate after tooth extraction e to discuss the relation between both things.Descriptors: Nervous System Disease; Celiac Disease; Molar, Third.ReferencesFasano A, Catassi C. Clinical practice. Celiac disease. N Engl J Med 2012; 367(25):2419-26.Guandalini S, Assiri A. Celiac disease: a review. JAMA Pediatr. 2014;168(3):272-78.de Carvalho FK, de Queiroz AM, Bezerra da Silva RA, Sawamura R, Bachmann L, Bezerra da Silva LA et al. Oral aspects in celiac disease children: clinical and dental enamel chemical evaluation. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015,119(6):636-43.Sanders DS, Patel D, Stephenson TJ, Ward AM, McCloskey EV, Hadjivassiliou M et al. A primary care cross-sectional study of undiagnosed adult celiac disease. Eur J Gastroenterol Hepatol 2003;15(4):407-13.Briani C, Zara G, Alaedini A, Grassivaro F, Ruggero S, Toffanin E et al. Neurological complications of coeliac disease and autoimmune mechanisms: a prospective study. J Neuroimmunol 2008;195(1-2):171-75.Bataineh AB. Sensory nerve impairment following mandibular third molar surgery. J Oral Maxillofac Surg. 2001;59(9):1012-17.Green PH. The many faces of celiac disease: clinical presentation on celiac disease in the adult population. Gastroenterology. 2005;128(4Suppl1): S74-8.Muller AF, Donnelly MT, Smith CM, et al. Neurological complications of celiac disease: a rare but continuing problem. Am J Gastroenterol. 1996; 91(7):1430-35.Chin RL, Snader HW, Brannagan TH, Green PH, Hays AP, Alaedini A et al. Celiac neuropathy. Neurology. 2003;60(10):1581-85.Alaedini A, Green PH, Sander HW, Hays AP, Gamboa AT, Fasano A et al. Ganglioside reactive antibodies in the neuropathy associated with celiac disease. J Neuroimmunol. 2002; 127(1-2):145-48.Oh SJ, Melo AC, Lee DK, Cichy SW, Kim DS, Demerci M et al. Large fiber neuropathy in distal sensory neuropathy with normal routine nerve conduction. Neurology.2001;56(11):1570-72.
Facile and simultaneous separation of nitrogen, phosphorus and bacteria from urine by using ash depth filters which harvest ammonium and phosphate as Struvite Enriched Ash
Authors: Witty Michael , Al-Bahou Raja , Copley Sarah , Dingra Nin N. , Ayudhya Theppawut Israsena Na 
Published: April 2020

Abstract
Ash depth filters were developed which can simultaneously remove nitrogen, phosphorus and bacteria from human waste streams while simultaneously maintaining a flow rate which is acceptable for domestic use processing urine from one individual for 1 month if the filter bed has a volume of approximately 3 l. Nitrogen and phosphorus depletion is achieved by the formation of Struvite Enriched Ash, which can subsequently be used as a slow-release garden fertilizer. Depth filtration and sanitation by high pH removed all detectable bacteria from this home-based system.
Current Status of Computational Intelligence Applications in Dermatological Clinical Practice
Authors: Rodríguez-Cerdeira Carmen , González-Cespón José Luís , Arenas Roberto 
Published: April 2020

Background:
The yeast infections are increasingly frequent and the correct diagnosis consists of the identification of the yeast fungus, which in our case we are going to refer to the different species of Candida. The prescription of a broad-spectrum antifungal without taking into account the etiological agent, leads to an increase in the resistance to these treatments.

Objective:
The objective of this work is to differentiate Candida albicans from other Candida species (Candida spp.) By means of digital images obtained from the optical microscope.

Material and Methods:
It has reviewed about 100 photographs from patients in our consultations.
In this study we will use the microscopic images of the Candida variety to be processed later with the Octave programming language and its image processing package (image-2.8.0).

Results and Discussion:
This system is able to differentiate Candida albicans from the other varieties of Candida such as C. parapsilosis, C. krusei, and C. kefyr with accuracy.
The candida identifier application, which was designed and programmed in Octave, allows identification of candida species by locating certain geometric descriptors, such as the centroid and the surfaces of circular objects within the images. The program was highly effective for the diagnosis of Candida spp. So, we got a sensitivity and specificity above 90% with the images used.

Conclusion:
The results that we obtain from the Candida spp. identifier system that opens the way to be able to work with images obtained from the optical microscope.
FEATURES OF MOUNTED VENTILATED FACADE HEAT CONTROL SYSTEMS IN CONSTRUCTION PROJECTS
Authors: Karpov D. F. , Pavlov M. V. , Sinitsyn A. A. , Monarkin N. N. , Gudkov A. G. 
Published: April 2020

Abstract. Aim.An integral part of an energy audit of buildings and structures consists in thermal imaging diagnostics. This permits an evaluation of the heat-shielding properties of the enclosing structures of buildings in order to control the functional and operational status of engineering systems, as well as to identify implicit (invisible) and explicit (visible) defects in them. The aim of the work is to analyse some features and results of thermal control of an opaque hinged ventilated facade system and translucent enclosing structures in the form of window systems of a capital construction project.Method.Thermal imaging was used as a control for resolving issues of energy and resource conservation. The special importance of thermal control of translucent facade systems and non-translucent hinged ventilated facades of capital construction projects having various functional and operational purposes is highlighted.Results.A detailed algorithm is presented for supporting a comprehensive diagnosis of the heat engineering state of building envelopes for various construction projects by analysing thermograms, using thermal monitoring methods, to take into consideration engineering systems, building materials and finished products, along with technologies of full-scale thermal imaging inspection of translucent building envelopes. The obtained thermograms are presented and analysed.Conclusion.Current problems in the fields of energy efficiency and energy saving in the construction and energy industries are considered in the light of the latest technological developments. The proposed graph-analytical algorithm supporting a diagnosis of the heat engineering state of building envelopes based on the analysis of thermograms is the most comprehensive among known analogues and prototypes
MENINGKATKAN PENULISAN E-RELATIONS BERBASIS INTERNET PADA MEDIA PUBLIKASI UNTUK PENGELOLA RPTRA JAKARTA BARAT
Authors: Erlita Novi 
Published: April 2020

Manfaat Internet sangat beraneka ragam bagi masyarakat dalam dunia digital. Manfaat Internet berbasis website, jejaring Sosial serta Blog merupakan suatu hal yang berimplikasi pada dampak postif dan dampak negatif pengelolaRPTRA Jakarta Barat dalam mempublikasikan program-program kelurahan di Jakarta Barat. Saat ini tekhnologi semakin maju bahkan dalam beberapa tahun terakhir ini perkembangan New Media sangat pesat yang dulunya internetdigunakan oleh kalangan atas saja namun sekarang internet dapat dinikmati oleh siswa-siswi SMU dengan biaya yang relatif terjangkau dengan akses internet melalui apa saja mulai dari komputer, handphone, laptop, gadget dan lain sebagainya. Manfaat internet secara umum berpengaruh besar bagi masyarakat karena dengan berbasis internet mampu membangun e-relations seperti Website, Jejaring Sosial dan Blog. Selain itu banyak konten internet yang menyediakan informasi edukatif baik lokal maupun global dari berbagai ilmu pengetahuan yang dibutuhkan pengelola RPTRA. Selain itu dengan membangun e-relations pengelola RPTRA mampu berkomunikasi serta dapat menggunakannya dengan tepat guna.