bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can a Broad Molecular Screen Based on Circulating Tumor DNA Aid in Early Cancer Detection?
Authors: Fiala Clare , Diamandis Eleftherios P 
Published: August 2020

Abstract
Early detection of cancer has been a major research focus for almost a century. Current methods for early cancer detection suffer from suboptimal sensitivity and specificity, especially when used for population screening. For most major cancers, including breast, prostate, lung, ovarian, and pancreatic cancer, population screening is still controversial or is not recommended by expert bodies. Circulating tumor DNA (ctDNA) is an exciting new cancer biomarker with potential applicability to all cancer types. Recent investigations have shown that genetic alterations or epigenetic modifications in ctDNA could be used for cancer detection with a liquid biopsy (i.e., a tube of blood). Tests based on ctDNA have attracted considerable attention for various applications, such as patient management, prognosis, early diagnosis, and population screening. Recently, new biotechnology companies were founded, with the goal of revolutionizing early cancer detection by using ctDNA. We previously examined this technology, as published by various academic laboratories and of one leading company, Grail, and drew attention to potential obstacles. After 3 years of intense development, this technology seems to have made some progress. Here, we will analyze the latest clinical data presented by Grail in October 2019, during the inaugural American Society of Clinical Oncology (ASCO) 2019 Breakthrough Conference. Despite considerable technical improvements, it seems that the sensitivity and specificity of the Grail test as a pan-cancer screening tool are still too low for clinical use. The prospects that this test could be further improved are also discussed.
Delirium in Burn Patients: Developing a Mobile Application for Assessment and Diagnosis
Authors: Mohseni Moallem Kolaei Najibeh , Ayatollahi Haleh , Elyasi Forouzan 
Published: August 2020

Abstract
Delirium is a neuropsychiatric syndrome which is highly prevalent among hospitalized burn patients. Among screening tools, the Intensive Care Delirium Screening Checklist (ICDSC) is a reliable tool. This study aimed to develop a mobile-based application for assessing and diagnosing delirium in burn patients by using ICDSC. This research consisted of three phases. Initially, a questionnaire was designed and users’ requirements were identified. The participants were 10 psychiatrists and 51 nurses. Then, a mobile application was designed based on the results derived from the first phase of the study and the usability of the application was evaluated by using a standard questionnaire. Finally, the rate of agreement between the nurses’ and physiatrists’ diagnoses made by using or not using the application was calculated. The application included educational content about delirium for nurses, patient data, and some functions. The results of the usability evaluation showed that the application was at a “good” level from the users’ perspectives and the rate of agreement between the nurses’ and physiatrists’ diagnoses made by using the application was higher than not using it. The application designed in the current study can help us to improve the knowledge of nurses, in particular younger nurses regarding delirium. Moreover, making diagnosis based on the results of a delirium assessment tool is more accurate than relying on nursing experience. Finally, timely diagnosis of delirium can help us to improve patient management and quality of care, reduce the duration of hospitalization, and decrease the mortality rate and costs.
The Preference for Moderation Scale
Authors: Drolet Aimee , Luce Mary Frances , Jiang Li , Rossi Benjamin C , Hastie Reid 
Published: August 2020

AbstractWe propose that individual differences in the value placed on the principle of moderation exist and influence many aspects of consumer decision-making. The idea that moderation is an important guiding norm of human behavior is prevalent throughout history and an explicit theme in many philosophies, religions, and cultures. Yet, moderation has not been studied as an individual-level determinant of consumer behavior. We develop a scale that measures the degree to which individuals have a Preference for Moderation (PFM). The PFM scale predicts consequential behavior in many decision contexts. We first report on scale development, including the generation and selection of items. We then report analyses showing that PFM is distinct from several popular individual-difference variables. Related to cultural background, PFM reliably predicts the use of compromise (study 1) and balancing (vs. highlighting) strategies (study 2), as well as various decision-making behaviors, including reliance on the representativeness heuristic (study 3), self-reported financial habits and outcomes (studies 4–5), real-world online-reviewing behavior (study 6), and split-ticket voting behavior in the 2018 US midterm elections (study 7).
On learning context-aware rules to link RDF datasets
Authors: Cimmino Andrea , Corchuelo Rafael 
Published: August 2020

Abstract
Integrating RDF datasets has become a relevant problem for both researchers and practitioners. In the literature, there are many genetic proposals that learn rules that allow to link the resources that refer to the same real-world entities, which is paramount to integrating the datasets. Unfortunately, they are context-unaware because they focus on the resources and their attributes but forget about their neighbours. This implies that they fall short in cases in which different resources have similar attributes but refer to different real-world entities or cases in which they have dissimilar attributes but refer to the same real-world entities. In this article, we present a proposal that learns context-aware rules that take into account both the attributes of the resources and their neighbours. We have conducted an extensive experimentation that proves that it outperforms the most advanced genetic proposal. Our conclusions were checked using statistically sound methods.
Male size and alternative mating tactics in white-tailed deer and mule deer
Authors: Airst Jason I , Lingle Susan 
Published: August 2020

Abstract
Within populations, individual males adopt different courtship tactics due to differences in their competitive ability, which may vary depending on the animal’s age and size. To test the hypothesis that mule deer (Odocoileus hemionus) and white-tailed deer (O. virginianus) males vary their courtship behavior based on their size, we conducted focal observations of 144 mule deer and 85 white-tailed males that varied in size, at a large grassland site in southern Alberta. The smallest mule deer males devoted more time to feeding, were less likely to engage in late-stage courtship than larger males and were less likely to move among female groups. Other males, including small white-tailed males, appeared to use a roving strategy to search for estrous females in different groups, which is consistent with recent research on male movements. Both medium and large males increased the time they spent in one-male groups, and specifically isolated pairs, as courtship advanced, presumably to reduce competition with other males. However, this trend was most pronounced for medium mule deer males, and for all size classes of white-tailed deer. In contrast, large mule deer males spent a similar proportion of time tending females in all group types. Our results identified potential size-dependent tactics for mule deer males. In contrast, white-tailed males of all sizes appeared to rely on a tactic of finding and tending estrous females in isolation from other males.
Fluorine in the solar neighbourhood: modelling the Galactic thick and thin discs
Authors: Grisoni V , Romano D , Spitoni E , Matteucci F , Ryde N , Jönsson H 
Published: August 2020

ABSTRACT
We investigate the evolution of the abundance of fluorine in the Milky Way thick and thin discs by means of detailed chemical evolution models compared with recent observational data. The chemical evolution models adopted here have already been shown to fit the observed abundance patterns of CNO and α-elements as well as the metallicity distribution functions for the Galactic thick and thin disc stars. We apply them here to the study of the origin and evolution of fluorine, which is still a matter of debate. First, we study the importance of the various sites proposed for the production of fluorine. Then, we apply the reference models to follow the evolution of the two different Galactic components. We conclude that rotating massive stars are important producers of F and they can set a plateau in F abundance below [Fe/H] = −0.5 dex, though its existence for [Fe/H]&lt;−1 has yet to be confirmed by extensive observations of halo stars. In order to reproduce the F abundance increase in the discs at late times, instead, a contribution from lower mass stars – single asymptotic giant branch stars and/or novae – is required. The dichotomy between the thick and thin discs is more evident in the [F/O] versus [O/H] plot than in the [F/Fe] versus [Fe/H] one, and we confirm that the thick disc has evolved much faster than the thin disc, in agreement with findings from the abundance patterns of other chemical elements.
The dwarf planet Makemake as seen by X-Shooter
Authors: Alvarez-Candal Alvaro , Souza-Feliciano Ana Carolina , Martins-Filho Walter , Pinilla-Alonso Noemí , Ortiz José Luis 
Published: August 2020

ABSTRACT
Makemake is one of the brightest known trans-Neptunian objects, as such, it has been widely observed. Nevertheless, its visibility to near-infrared spectrum has not been completely observed in medium-resolving power, aimed at studying in detail the absorption features of CH4 ice. In this paper, we present the spectrum of Makemake observed with X-Shooter at the Very Large Telescope (Chile). We analyse the detected features, measuring their location and depth. Furthermore, we compare Makemake’s spectrum with that of Eris, obtained with the same instrument and similar setup, to conclude that the bands of the CH4 ice in both objects show similar shifts.
The completed SDSS-IV extended baryon oscillation spectroscopic survey: pairwise-inverse probability and angular correction for fibre collisions in clustering measurements
Authors: Mohammad Faizan G , Percival Will J , Seo Hee-Jong , Chapman Michael J , Bianchi D , Ross Ashley J , Zhao Cheng , Lang Dustin , Bautista Julian , Brinkmann Jonathan , Brownstein Joel R , Burtin Etienne , Chuang Chia-Hsun , Dawson Kyle S , de la Torre Sylvain , de Mattia Arnaud , Eftekharzadeh Sarah , Fromenteau Sebastien , Gil-Marín Héctor , Hou Jiamin , Mueller Eva-Maria , Neveux Richard , Paviot Romain , Raichoor Anand , Rossi Graziano , Schneider Donald P , Tamone Amélie , Tinker Jeremy L , Tojeiro Rita , Vargas Magaña Mariana , Zhao Gong-Bo 
Published: August 2020

ABSTRACT
The completed extended Baryon Oscillation Spectroscopic Survey (eBOSS) catalogues contain redshifts of 344 080 quasars at 0.8 &lt; z &lt; 2.2, 174 816 luminous red galaxies between 0.6 &lt; z &lt; 1.0, and 173 736 emission-line galaxies over 0.6 &lt; z &lt; 1.1 in order to constrain the expansion history of the Universe and the growth rate of structure through clustering measurements. Mechanical limitations of the fibre-fed spectrograph on the Sloan telescope prevent two fibres being placed closer than 62 arcsec in a single pass of the instrument. These ‘fibre collisions’ strongly correlate with the intrinsic clustering of targets and can bias measurements of the two-point correlation function resulting in a systematic error on the inferred values of the cosmological parameters. We combine the new techniques of pairwise-inverse probability and the angular upweighting (PIP+ANG) to correct the clustering measurements for the effect of fibre collisions. Using mock catalogues, we show that our corrections provide unbiased measurements, within data precision, of both the projected $\rm {\mathit{ w}_p}\left(\mathit{ r}_p\right)$ and the redshift-space multipole ξ(ℓ = 0, 2, 4)(s) correlation functions down to $0.1\, h^{-1}{\rm Mpc}$, regardless of the tracer type. We apply the corrections to the eBOSS DR16 catalogues. We find that, on scales $s\gtrsim 20\, h^{-1}{\rm Mpc}$ for ξℓ, as used to make baryon acoustic oscillation and large-scale redshift-space distortion measurements, approximate methods such as nearest-neighbour upweighting are sufficiently accurate given the statistical errors of the data. Using the PIP method, for the first time for a spectroscopic program of the Sloan Digital Sky Survey, we are able to successfully access the one-halo term in the clustering measurements down to $\sim 0.1\, h^{-1}{\rm Mpc}$ scales. Our results will therefore allow studies that use the small-scale clustering to strengthen the constraints on both cosmological parameters and the halo occupation distribution models.
Nested sampling cross-checks using order statistics
Authors: Fowlie Andrew , Handley Will , Su Liangliang 
Published: August 2020

ABSTRACT
Nested sampling (NS) is an invaluable tool in data analysis in modern astrophysics, cosmology, gravitational wave astronomy, and particle physics. We identify a previously unused property of NS related to order statistics: the insertion indexes of new live points into the existing live points should be uniformly distributed. This observation enabled us to create a novel cross-check of single NS runs. The tests can detect when an NS run failed to sample new live points from the constrained prior and plateaus in the likelihood function, which break an assumption of NS and thus leads to unreliable results. We applied our cross-check to NS runs on toy functions with known analytic results in 2–50 dimensions, showing that our approach can detect problematic runs on a variety of likelihoods, settings, and dimensions. As an example of a realistic application, we cross-checked NS runs performed in the context of cosmological model selection. Since the cross-check is simple, we recommend that it become a mandatory test for every applicable NS run.
Abell 30 - A binary central star among the born-again planetary nebulae
Authors: Jacoby George H , Hillwig Todd C , Jones David 
Published: August 2020

ABSTRACT
Eight planetary nebulae have been identified as ‘born-again’, a class of object typified by knotty secondary ejecta having low masses (${\sim}10^{-4}$ M⊙) with nearly no hydrogen. Abell 30, the archetype of the class, also belongs to a small subset of planetary nebulae that exhibit extreme abundance discrepancy factors (where Abell 30 is the most extreme), a phenomenon strongly linked to binary star interactions. We report the presence of light curve brightness variations having a period of 1.060 d that are highly suggestive of a binary central star in Abell 30. If confirmed, this detection supports the proposed link between binary central stars and extreme abundance discrepancies.
Spacer acquisition by Type III CRISPR–Cas system during bacteriophage infection of Thermus thermophilus
Authors: Artamonova Daria , Karneyeva Karyna , Medvedeva Sofia , Klimuk Evgeny , Kolesnik Matvey , Yasinskaya Anna , Samolygo Aleksei , Severinov Konstantin 
Published: August 2020

Abstract
Type III CRISPR–Cas systems provide immunity to foreign DNA by targeting its transcripts. Target recognition activates RNases and DNases that may either destroy foreign DNA directly or elicit collateral damage inducing death of infected cells. While some Type III systems encode a reverse transcriptase to acquire spacers from foreign transcripts, most contain conventional spacer acquisition machinery found in DNA-targeting systems. We studied Type III spacer acquisition in phage-infected Thermus thermophilus, a bacterium that lacks either a standalone reverse transcriptase or its fusion to spacer integrase Cas1. Cells with spacers targeting a subset of phage transcripts survived the infection, indicating that Type III immunity does not operate through altruistic suicide. In the absence of selection spacers were acquired from both strands of phage DNA, indicating that no mechanism ensuring acquisition of RNA-targeting spacers exists. Spacers that protect the host from the phage demonstrate a very strong strand bias due to positive selection during infection. Phages that escaped Type III interference accumulated deletions of integral number of codons in an essential gene and much longer deletions in a non-essential gene. This and the fact that Type III immunity can be provided by plasmid-borne mini-arrays open ways for genomic manipulation of Thermus phages.
Hippocampal avoidance whole-brain radiotherapy without memantine in preserving neurocognitive function for brain metastases: a phase II blinded randomized trial
Authors: Yang Wen-Chi , Chen Ya-Fang , Yang Chi-Cheng , Wu Pei-Fang , Chan Hsing-Min , Chen Jenny Ling-Yu , Chen Guann-Yiing , Cheng Jason Chia-Hsien , Kuo Sung-Hsin , Hsu Feng-Ming 
Published: August 2020

Abstract

Background
Hippocampal avoidance whole-brain radiotherapy (HA-WBRT) shows potential for neurocognitive preservation. This study aimed to evaluate whether HA-WBRT or conformal WBRT (C-WBRT) is better for preserving neurocognitive function.

Methods
This single-blinded randomized phase II trial enrolled patients with brain metastases and randomly assigned them to receive HA-WBRT or C-WBRT. Primary endpoint is decline of the Hopkins Verbal Learning Test–Revised (HVLT-R) delayed recall at 4 months after treatment. Neurocognitive function tests were analyzed with a mixed effect model. Brain progression-free survival (PFS) and overall survival (OS) were estimated using the Kaplan–Meier method.

Results
From March 2015 to December 2018, seventy patients were randomized to yield a total cohort of 65 evaluable patients (33 in the HA-WBRT arm and 32 in the C-WBRT arm) with a median follow-up of 12.4 months. No differences in baseline neurocognitive function existed between the 2 arms. The mean change of HVLT-R delayed recall at 4 months was −8.8% in the HA-WBRT arm and +3.8% in the C-WBRT arm (P = 0.31). At 6 months, patients receiving HA-WBRT showed favorable perpetuation of HVLT-R total recall (mean difference = 2.60, P = 0.079) and significantly better preservation of the HVLT-R recognition-discrimination index (mean difference = 1.78, P = 0.019) and memory score (mean difference = 4.38, P = 0.020) compared with patients undergoing C-WBRT. There were no differences in Trail Making Test Part A or Part B or the Controlled Oral Word Association test between the 2 arms at any time point. There were no differences in brain PFS or OS between arms as well.

Conclusion
Patients receiving HA-WBRT without memantine showed better preservation in memory at 6-month follow-up, but not in verbal fluency or executive function.
Virological Failure and Acquired Genotypic Resistance Associated With Contemporary Antiretroviral Treatment Regimens
Authors: Rhee Soo-Yon , Clutter Dana , Hare C Bradley , Tchakoute Christophe T , Sainani Kristin , Fessel W Jeffrey , Hurley Leo , Slome Sally , Pinsky Benjamin A , Silverberg Michael J , Shafer Robert W 
Published: August 2020

Abstract

Background
There are few descriptions of virologic failure (VF) and acquired drug resistance (HIVDR) in large cohorts initiating contemporary antiretroviral therapy (ART).

Methods
We studied all persons with HIV (PWH) in a California clinic population initiating ART between 2010 and 2017. VF was defined as not attaining virologic suppression, discontinuing ART, or virologic rebound prompting change in ART.

Results
During the study, 2315 PWH began ART. Six companion drugs were used in 93.3% of regimens: efavirenz, elvitegravir/c, dolutegravir, darunavir/r, rilpivirine, and raltegravir. During a median follow-up of 36 months, 214 (9.2%) PWH experienced VF (2.8 per 100 person-years) and 62 (2.7%) experienced HIVDR (0.8 per 100 person-years). In multivariable analyses, younger age, lower CD4 count, higher virus load, and atazanavir/r were associated with increased VF risk; lower CD4 count, higher virus load, and nevirapine were associated with increased HIVDR risk. Compared with efavirenz, dolutegravir, raltegravir, and darunavir were associated with reduced HIVDR risk. Risks of VF and HIVDR were not significantly associated with ART initiation year. Of the 62 PWH with HIVDR, 42 received an non-nucleoside RT inhibitor (NNRTI), 15 an integrase-strand transfer inhibitor (INSTI), and 5 a protease inhibitor (PI). Among those with HIVDR on an NNRTI or first-generation INSTI, 59% acquired dual class resistance and 29% developed tenofovir resistance; those receiving a PI or dolutegravir developed just M184V.

Conclusions
Despite the frequent use of contemporary ART regimens, VF and HIVDR continue to occur. Further efforts are required to improve long-term ART virological responses to prevent the consequences of ongoing HIV-1 replication including virus transmission and HIVDR.
An Expedited Transition to the Back Wall Suturing for Side-to-Side In Situ Microvascular Anastomosis: A Technique Update
Authors: Ravina Kristine , Fredrickson Vance L , Donoho Daniel A , Cavaleri Jonathon M , Strickland Ben A , Lam Jordan , Russin Jonathan J 
Published: August 2020

Abstract

BACKGROUND
The side-to-side in situ microvascular anastomosis is an important tool in the cerebrovascular neurosurgeon's armamentarium. The execution of the side-to-side anastomosis, however, can be limited by the inability to acquire sufficient visualization and approximation of the recipient and donor vessels.

OBJECTIVE
To expedite the transition to the back wall suturing of the donor and recipient vessels during side-to-side in situ microvascular anastomosis.

METHODS
Incorporation of the first suture throw from the outside to the inside of the vessel lumen with the initial stay suture at the proximal apex of the arteriotomy is described. The apical knot is tied between one limb of the resultant loop and the free end of the suture. The remainder of side-to-side anastomosis can then be completed in a standard fashion starting from the inside of the lumen.

RESULTS
This modification allows for an expedited transition to the back wall suturing of the 2 arterial segments and avoids difficulties associated with taking the first bite from behind the knot at the proximal apex of the arteriotomy or the transfer of the needle between the approximated vessels. This updated technique is illustrated with a case example, illustration, and video.

CONCLUSION
This technical modification for the side-to-side anastomosis helps optimize microsurgical efficiency by limiting needle, suture, and vessel handling after the initial suture placement, which has classically been a challenge of this bypass.