bluuebunny/crossref_metadata_2025_split huggingface dataset:
MR Imaging Features of Orbital Langerhans Cell Histiocytosis
Authors: wu chunnan , Mu xuetao , Hei yan , lan pengyu , li kuncheng 
Published: October 2019

Abstract
Background: To investigate the magnetic resonance imaging (MRI) features of orbital Langerhans cell histiocytosis (LCH) to improve diagnostic accuracy. Methods: We retrospectively reviewed clinical manifestations and MRI findings of 23 patients with histopathology-confirmed LCH of the orbit. The findings were evaluated for the following: (a) symptoms, (b) disease duration，(c) location, (d) configuration, (e) margin, (f) MR imaging signal intensity and enhanced performance. Results: Eighteen patients (78%) in our series were male, only five (22%) patients were female, and the mean age at presentation was 6.3 years. The common symptoms include swollen eyelids, exophthalmos, and a palpable mass. Fourteen patients presented with swollen eyelids and/or exophthalmos. Twenty-two cases involved unilateral orbits, and one case involved bilateral orbits. In our study, there was one patient with cough and expectoration, and one patient with polydipsia and polyuria. Lesions were located in the superior or superlateral orbital roof of seventeen patients (74%). Lesions formed masses or irregular shapes. The 12 out of 23 (52.2%)cases appeared heterogeneous isointense and 10 out of 23 (43.5%) cases showed iso-hypointense on T1-weighted imaging, there were 15 out of 23 (65.2%) cases showed hyper-hypointense mixed signals on T2-weighted imaging. 7 cases found patchy hyperintense signal on T1WI, and 11 cases showed markedly hyperintense signal near the edge of lesions on T2WI. After enhancement, 21 out of 23 (91.3%) cases lesions presented marked enhancement at the edges and the surrounding tissues, and with heterogeneous obvious enhancement of the lesion center. Besides, four cases lesions were surrounded by a low circular signal. Conclusion: There were several characteristics MRI features that can provide crucial information for clinicians and improve our understanding and the diagnostic accuracy of the orbital LCH.
Interaction between COX-1 and COX-2 increases susceptibility to ischemic stroke in a Chinese population
Authors: Zhao Lei , Fang Jinghuan , Zhou Muke , Zhou Jie , Yu Lihua , Chen Ning , He Li 
Published: October 2019

Abstract
Background:Mutations of cyclooxygenase gene (COX gene) may increase the susceptibility of ischemic stroke. We investigated five variants (rs5788, rs1330344, rs3842788, rs20417, and rs689466) of two COX genes in order to explaining the association between these polymorphisms and we also investigated the association between these variants and ischemic stroke risk to determine whether gene–gene interaction between these genes increases the susceptibility of ischemic stroke or its subtypes.
Method: A total of 1981 study subjects (1078 cases and 903 control subjects) were recruited. The interaction of multiple factors was investigated using Multifactor Dimensionality Reduction. The additive effect of single nucleotide polymorphisms on ischemic stroke or its subtypes were analyzed by multiple factor logistic regression.
Results: At COX-1(rs1330344), AA genotype carriers had a lower susceptibility of ischemic stroke ( OR=0.657, 95%CI= 0.437-0.988, P = 0.044 ), and A allele carriers had a lower susceptibility of ischemic stroke ( OR=0.812, 95%CI= 0.657-0.978, P = 0.029 ). At COX-1(rs3842788), AA genotype carriers had a higher susceptibility of ischemic stroke ( OR =5.203, 95% CI=1.519-5.159, P =0.016) . At COX-2 (rs689466), AA genotype carriers had a higher susceptibility of large-artery atherosclerosis ( OR =1.404, 95% CI=1.019-1.934, P =0.038 ). COX-1(rs1330344, rs3842788) and COX-2 rs689466 interacted in SVO, but had no additive effect with ischemic stroke and other subtypes.
Conclusions: At rs1330344, AA genotype may reduce the susceptibility of ischemic stroke. At rs3842788, AA genotype may increase the susceptibility of ischemic stroke. At rs689466, AA genotype may increase the susceptibility of large-artery atherosclerosis (LAA). COX -1(rs1330344, rs3842788) and COX-2 rs689466 interacted in small vessel occlusion (SVO), but had no additive effect with ischemic stroke and other subtypes.
DAKWAH ISLAM DENGAN PENDEKATAN BIMBINGAN DAN KONSELING
Authors: Prihatiningtyas Siti 
Published: October 2019

<p><em>Humans need the help of others in solving their life problems. Life problems always develop, along with the times. The problems faced by humans also change. This change provides a treatment from various parties, including da'wah as an alternative way to solve human problems. Da'wah with various elements has responsibility in solving human problems. Da'wah is carried out by various means, one of which is guidance and counseling, both of which are used as references in carrying out da'wah. Something that is needed now is to increase the role of da'wah with guidance and counseling, so as to be able to solve human problems. This article focuses on the elaboration of guidance and counseling in solving human problems within the framework of da'wah</em><em></em></p><p align="center"> </p><p align="center">****</p><p align="center"> </p>Manusia memerlukan bantuan orang lain dalam menyelesaikan persoalan hidupnya. Persoalan kehidupan selalu berkembang, seiring dengan perkembangan zaman. Persoalan yang dihadapi manusia juga mengalami perubahan. Perubahan ini memberikan sebuah perlakuan dari berbagai pihak, termasuk dakwah sebagai alternatif jalan menyelesaikan masalah manusia. Dakwah dengan berbagai unsurnya mempunyai tanggungjawab dalam menyelesaikan persoalan manusia. Dakwah dilakukan dengan berbagai jalan, salah satunya adalah bimbingan dan konseling, Kedua hal ini dijadikan sebagai referensi dalam melaksanakan dakwah. Sesuatu yang dibutuhkan saat ini adalah meningkatkan peran dakwah dengan bimbingan dan konseling, sehingga mampu menyelesaikan masalah manusia. Artikel ini fokus pada elaborasi bimbingan dan konseling dalam menyelesaikan persoalan manusia dalam kerangka dakwah.
Interception of sediment-liberated phosphate in a surface aquatic system for eutrophication control
Authors: Gao Ge , Yang Shengjiong , Xu Huining , Dzakpasu Mawuli , Jin Pengkang , Wang Xiaochang C. 
Published: October 2019

Abstract
Phosphorus internal loading from the sediment of a surface aquatic system is considered to be the primary source of phosphorus responsible for eutrophication. In this study, we propose a possible solution to intercept phosphorus liberated from sediment to overlying water by a membranous nano-barrier (MNB) with tunable capacity. The equilibrium could be attained within 2 h when the MNB interacted with phosphate-containing water. The intercepting capacity was almost unaffected when the solution pH was varied from 4 to 10. The laboratory-scale trial showed that the MNB could positively intercept phosphorus liberated from sediment when the MNB covered the sediment, and the MNB was easy to replace once it became phosphate saturated, making its actual application feasible. Generally, the novel MNB can be considered to be a possible pathway for eutrophication control in shallow surface aquatic systems and scenic water.
Syntheses and Biological Activities of triazole-based Sulfonamides
Authors: Ramazani Ali , Sadighian Hamed , Gouranlou Farideh , Joo Sang W. 
Published: October 2019

:The triazole and sulfonamide compounds are known as biologically active agents that were employed for medicinal applications. These compounds were obtained in different forms by a variety of techniques to vast ranges of applications. The broad biological properties of these compounds have encouraged researchers to design and synthesize triazole-based sulfonamide derivatives as compounds with potential biological activity. In this review, we summarized the synthetic procedures of triazole-based sulfonamide compounds together with their biological activities during the last two decades.
Oral Bioavailability Enhancement of Amisulpride: Complexation and its Pharmacokinetics and Pharmacodynamics Evaluations
Authors: B. Prajapati Jagruti , K. Sawant Krutika , Dubey Bhramanand 
Published: October 2019

Background:
Many CNS drugs have low bioavailability due to their poor water solubility of
extensive first-pass metabolism and hence have less effectiveness.

Objective:
The present study aims to enhance the solubility and oral bioavailability of poorly watersoluble
antipsychotic drug Amisulpride (AMS) through complexation with 2-hydroxypropyl β-
cyclodextrin (HPβCD). It has slow and erratic absorption after oral administration.

Methods:
This report describes the study of the phase solubility diagram, preparation of the inclusion
complex and tablet of prepared inclusion complex, characterization of the physico-chemical properties
of the inclusion complex and tablet.

Results:
In-vitro study (100 % drug release in 15 minutes), and in-vivo study of an AL-type (linear type)
phase solubility diagram indicated a complex of AMS-HP-β-CD with the constant complex formation
of 13245 M−1 at 37°C. The complex formation was confirmed by DSC, IR, and X-ray diffraction. The
extent of absorption of the complex was determined in rats and was compared with that of pure drug
and the market product. The peak plasma concentration of pure drug was 30.05 ± 1.3 ng/ml (Cmax) at 60
± 3 min, whereas with the market product the value was 54.85 ± 1.2 ng/ml at 40 ± 1 min and with
AMS-HPβCD inclusion complex the value was 79.01 ± 1.5 ng/ml. The AUCtot of the pure drug was
2980.34±3.6, the market product was 7238.73±2.9 and of the inclusion complex was 11871.1±2.8.

Conclusion:
Pharmacodynamic studies in mice showed improved effectiveness of drug compared to
pure drug. The oral bioavailability of AMS was improved from 48% to 78%.
La evaluación clínica objetiva estructurada desde el área de formación médica general
Authors: Gómez-Peña Luis , Dávalos Espinosa Litzi Gabriela , Rodríguez Prieto Paul Fernando , Blanco Zabala Elizabeth , Viera Hernández Raiza Verónica , Rocha Cisneros Ivonne De la Caridad 
Published: October 2019

Introducción: Desde hace unos años, la educación asiste a cambios en la formación. Se intenta pasar de una formación basada en la adquisición pasiva de conocimientos teóricos, a otra formación más activa, dinámica y reflexiva. La forma ideal de evaluar la capacidad profesional es observar qué hace el médico ante las situaciones habituales en su consulta. Como esto entraña grandes dificultades técnicas, se han diseñado instrumentos que se aproximan bastante a la realidad, como la evaluación clínica objetiva estructurada.
Objetivo: El objetivo fue aplicar una evaluación clínica objetiva estructurada para valorar las habilidades clínicas en estudiantes de quinto semestre.
Método: Se conformó un comité de prueba con 4 docentes del área de formación médica general. Se realizó una tabla de especificaciones de habilidades clínicas para evaluar a los estudiantes con los casos clínicos planificados, fueron incluidas la anamnesis, examen físico, juicio clínico, diagnóstico anatofisiológico, habilidades imagenológicas y comunicación terapéutica. Se diseñaron 4 estaciones, se validó a través del juicio de expertos su contenido y se calculó la validez predictiva de las listas de cotejo. Se aplicó la prueba a 17 estudiantes, se validó el instrumento, se obtuvieron resultados de la estadística descriptiva y se calculó el alfa de Cronbach.
Resultados: El análisis de concordancia del instrumento de evaluación según los expertos, fue aceptable, pues la condición de esencial superó el 80%; la validez predictiva y el alfa de Cronbach en 3 de las estaciones fue significativo, la cardiopatía chagásica fue la mejor evaluada con 97.5 y el alfa de Cronbach general fue de 0.507.
Conclusiones: Los instrumentos utilizados en la evaluación clínica objetiva estructurada tienen la validez y confiabilidad suficiente para ser aplicados en el contexto investigativo y mejorar la calidad de las evaluaciones clínicas, haciéndolas más objetivas y con mayores posibilidades de retroalimentación en el proceso de aprendizaje.
Identidad y lengua en el ciberespacio: ¿existe una conciencia lingüística digital?
Authors: López Muñoz Juan Manuel 
Published: October 2019

En el orden del ciberespacio, muchos internautas se denominan a sí mismos nativos o indígenas digitales, constituyendo una nueva comunidad étnica ajena a las fronteras territoriales y culturales del mundo físico, unidos por lo que podríamos llamar una misma “conciencia digital”. En este artículo estudiamos cómo se manifiesta esa conciencia digital a través de las expresiones que los usuarios de Twitter emplean para hablar de quiénes son y qué hacen cuando comunican por ordenador o por otros dispositivos conectados a la red de Internet. Nuestro objetivo es intentar sistematizar algunas características específicas de la lengua digital, con el fin de proponer algunas pistas para la pedagogía de la lengua digital y participar en el debate de “buen uso” de la lengua digital en el marco de la cortesía digital.------------------------------------------------------------------------------------------IDENTIDADE E LÍNGUA NO CIBERESPAÇO: EXISTE UMA CONSCIÊNCIA LINGUÍSTICA DIGITAL?Na ordem do ciberespaço, muitos internautas se autodenominam nativos ou indígenas digitais, constituindo uma nova comunidade étnica fora das fronteiras territoriais e culturais do mundo físico. Eles têm em comum o que poderíamos chamar de a mesma "consciência digital". Neste artigo, estudamos como essa consciência digital se manifesta por meio das expressões que os usuários do Twitter empregam para falar sobre quem são e o que fazem quando se comunicam por computador ou outros dispositivos conectados à rede da Internet. Nosso objetivo é tentar sistematizar algumas características específicas da linguagem digital, a fim de propor algumas pistas para sua pedagogia e participar do debate do "bom uso" da linguagem digital no contexto da cortesia digital.---Original em espanhol.
Evaluación del desempeño por competencias
Authors: Párraga-Zambrano Lenin 
Published: October 2019

La investigación fue de carácter descriptivo con el objetivo de analizar el desempeño del talento humano de la cooperativa de suministros tecnológicos de Manabí. El 65% de los encuestados no recibe comentarios referentes a su propio desempeño lo cual demuestra que la organización no es consciente del rol primordial que representan sus recursos humanos en desarrollo para fortalecer su desempeño, es decir que en dicha organización no se valora el recurso humano como ente proveedor que permite alcanzar los objetivos individuales relacionados directa o indirectamente con la organización. La evaluación del desempeño valora sistemáticamente el desempeño que posee cada persona en función de las actividades que cumple y de las metas y resultados a alcanzar ya que la misma debe realizarse siempre con proporción al perfil del puesto que ocupa para luego poder dar la retroalimentación y comentar los progresos del evaluado.
Hacia la novela de la democracia: relevo generacional y debate estético en Ínsula 1966-1985
Authors: Castro Díez Asunción 
Published: October 2019

Este artículo estudia la recepción que la revista Ínsula hizo de los cambios estéticos que se dieron en la narrativa española entre 1966 y 1985. Concretamente, se centra en la aparición de una nueva promoción de escritores, conocidos como “Generación del 68” o “Generación del 75”, que empiezan a publicar sus novelas desde finales de los años 60. En esos años, el panorama literario español estaba dominado por la confrontación entre dos estéticas: realismo y tradición frente a experimentalismo y renovación. Pero los jóvenes escritores ya no están interesados en esta dialéctica, no se ajustan a un único modelo narrativo y presentan modalidades muy diferentes, en una concepción abierta y plural del género que es bien valorada en la revista.
PENERAPAN MODEL PEMBELAJARAN POE (PREDICT, OBSERVE, EXPLAIN) TERHADAP HASIL BELAJAR SISWA KELAS V DI SDN PANGARANGAN III SUMENEP
Authors: Fahrinnisak Fahrinnisak 
Published: October 2019

Tujuan dari penelitian ini adalah: (1) untuk mengetahui keterlaksanaan penerapan model pembelajaran POE pada pembelajaran IPA terhadap hasil belajar siswa; (2) Apakah penerapan model pembelajaran POE pada pembelajaran IPA dapat meningkatkan ketuntasan hasil belajar siswa; (3) Bagaimanakah aktivitas belajar siswa pada pembelajaran IPA dengan menggunakan model pembelajaran POE; (4) Bagaimanakah respon belajar siswa setelah mengikuti pembelajaran IPA dengan menggunakan model pembelajaran POE. Penelitian ini dilaksanakan di SDN Pangarangan III Sumenep. Subjek penelitian ini adalah kelas V (lima) dengan jumlah siswa 15 orang. Rancangan penelitian yang digunakan adalah PenelitianTindakanKelas (PTK) yang terdiri dari 2 siklus. Teknik pengumpulan data yang digunakan antara lain :observasi, tes, dan mengisi angket. Hasil penelitian menunjukkan bahwa penerapan model POE dapat meningkatkan hasil belajar siswa. Hal ini terbukti dari hasil yang diperoleh yaitu pada siklus I 1,68 menjadi 75,33 pada siklus II. Keterlaksanaan guru pada siklus I 60,3 % dengan kategori sedang menjadi 81,5 % dengan kategori tinggi pada siklus II. Sedangkan keterlaksanaan siswa yaitu pada siklus I 70,15% dengan kategori sedang menjadi 82,05% dengan kategori tinggi pada siklus II. Nilai rata-rata respon siswa pada siklus I 76,67% menjadi 90,67% dengan kategori sangat baik.
Using queuing theory to solve the problem of momentum to issuing the driving licenses in Dohuk city
Authors: Nacy Nabeel G. , Ibrahim Samaher T. 
Published: October 2019

Queuing theory is a mathematical study of so-called queues or waiting lines. This phenomenon is common in daily life as in gas stations, airports, repair workshops and other common everyday examples. Waiting occurs when service demand is higher than service system power. Due to the difficulty in predicting the number of customers arriving and the time taken by the customer at the service station, the process of obtaining performance metrics is necessary before the queuing systems are implemented. When the service system power is too high, the system is charged at a high cost. Conversely, when the system power is low (insufficient for the customer service), the waiting time in the queue increases, As well as loss of order to its customers. Therefore, attention has been drawn to the so-called theory of waiting lines to solve such problems to reach a balance in the work of the system.
This research aims to overcome the difficulties experienced by citizens in obtaining market holidays on time and reduce waste in time and the cost of waiting.
The results were as shown in tables (l) to (6) of the city center and according to the distribution of access and service of the model used (G / G / C). We note in the Poisson distribution with exponential that the average number of customers in the system Ls = 5.527), which is approximately (5 customers), which is waiting in the system. We note in the previous distribution itself that the average number of customers in the waiting queue (customer 2.1924 = L q) is approximately 2 (customer) which is waiting in queue. The Poisson distribution with the exponential is that the average time spent by the customer in the system (minute W s = 16.5772). Note in the Poisson distribution with the exponential that the average time spent by the customer in the waiting queue is (minute W = 6.5772) We note in the Poisson distribution with exponential that The average number of customers in the system (customer Ls = 4.3258) is about (4 customers) which is waiting in the system. We see in the previous distribution itself that the average number of customers in the queue (customer 2.0 = L q) ) There is no waiting in the queue. The Poisson distribution with exponential is the average time spent by the customer in the system (min W s = 11.3333). We note in the Poisson distribution with exponential that the average time spent by the customer in the waiting queue is (min W q = 4.6666)
Radiotherapy and geriatric cancer patients: A single institute experience
Authors: Suhag Virender , BS Sunita , Vats Pankaj , Singh Shalendra , Jain Mayuri , Vashisht R 
Published: October 2019

Objectives:
The aim of this study was to study patient, disease, and treatment related characteristics in geriatric patients 65 years and older treated by Radiotherapy (RT).

Material and methods:
A retrospective observational and descriptive study was conducted in a tertiary care gov- ernment institute with academic and research potential. The electronic medical records, medical documents, and Radiotherapy treatment charts were retrieved and studied.

Results:
247 patients aged 65 years and older were included over 2-year study period. Mean age was 70.3 years and the oldest patient treated was of 94 years. 66% patients were males. 82 patients (33%) had metastatic disease. The common sites of origin were head and neck (28%), lung (23%), genitourinary (20%), and gastrointestinal malig- nancies (15%). 125 patients (51%) were having one or more co-morbidities. 135 patients (55%) were treated with radical intent. 66 patients (27%) received chemotherapy in concurrent setting. 89 patients (36%) were hospitalized for some duration of their RT course. In 58 patients (23%), RT was interrupted briefly. 46 patients (19%) could not complete the prescribed RT. 8 patients (3%) developed Grade 3 and 4 hematological toxicities. 57% patients developed Grade 2,3 mucocutaneous toxicities. 53% patients developed Grade 2,3 GI toxicities. Mortality rate while on treatment was 4%.

Conclusion:
Geriatric patients, though more prone to develop systemic and site-specific toxicities warranting supportive care in indoor or outdoor setting, can be offered Radiotherapy either alone or concurrently with che- motherapy. Such patients present with heterogeneous spectrum of entities often posing a therapeutic challenge to clinicians; but proper selection of cases and diligent supervision may allow these patients to be treated with Radiotherapy with radical or palliative intent as indicated.