bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-aluminum orthopyroxene megacrysts (HAOM) in the Ahvenisto complex, SE Finland, and the polybaric crystallization of massif-type anorthosites
Authors: Heinonen Aku , Kivisaari Heli , Michallik Radoslaw M. 
Published: December 2019

AbstractThe occurrence of high-aluminum orthopyroxene megacrysts (HAOMs) in several massif-type Proterozoic anorthosite complexes has been used as evidence of their polybaric crystallization. Here, we report such petrographic and geochemical (XRF and EMPA) evidence from HAOMs discovered in the 1.64 Ga Ahvenisto rapakivi granite—massif-type anorthosite complex in southeastern Finland. Two different types of HAOMs were recognized: type 1 HAOMs are individual, euhedral-to-subhedral crystals, and up to 15 cm in diameter, and type 2 HAOMs occur in pegmatitic pockets closely associated with megacrystic (up to 30 cm long) plagioclase. The type 1 megacrysts in particular are surrounded by complex corona structures composed of plagioclase, low-Al orthopyroxene, iddingsite (after olivine), and sulfides. Orthopyroxene crystallization pressure estimates based on an Al-in-Opx geobarometer reveal a three-stage compositional evolution in both textural HAOM types. The Al content decreases significantly from the core regions of the HAOM (4.4–7.6 wt% Al2O3), through the rims (1.3–3.6 wt%), into the host rock (0.5–1.5 wt%). Enstatite compositions overlap, but are generally higher in the cores (En~60–70) and rims (En~50–70) of the HAOMs than in the host rock (En~45–60) orthopyroxenes. The highest recorded Al abundances in the HAOM cores correspond to crystallization pressures of up to ~ 1.1 GPa (~ 34 km depth), whereas the HAOM rims have crystallized at lower pressures (max. ~ 0.5 GPa, 20 km depth). The highest pressure estimates for the host rock orthopyroxene were ~ 0.2 GPa (< 7 km depth). These observations confirm the polybaric magmatic evolution of the Ahvenisto anorthosites and suggest that the entire 1.65–1.55 Ga Fennoscandian rapakivi suite was emplaced at a relatively shallow level (< 7 km depth) in the upper crust. Global comparison to similar rock types reveals remarkable similarities in the petrogenetic processes controlling HAOM composition and evolution of anorthosite parental magmas.
When exotic introductions fail: updating invasion beliefs
Authors: Heersink Daniel K. , Caley Peter , Paini Dean , Barry Simon C. 
Published: December 2019

AbstractDecisions regarding invasive risk of exotic species are often based on species distribution models projected onto the recipient region of interest. Such projections are essentially a measure of prior belief in the ability of an organism to invade. Whilst many decisions are made on the basis of such projections, it is less clear how such prior belief may be empirically modified on the basis of data, in particular introduction events that haven’t led to establishment. Here, using the Asian green mussel (Perna viridis) as an example, we illustrate how information on failed introduction attempts may be used to continually update our beliefs in the ability of an organism to invade per introduction, and the underlying habitat suitability for establishment. Our results show that the establishment probability ofP. viridisper fouled ship visit in the supposedly favourable northern Australian waters are much lower than initially though, and are continuing to decline. A Bayesian interpretation of our results notes the dramatic reduction in our belief of the ability ofP. viridisto invade in the light of what we estimate to be 100’s of fouled vessels per year visiting ports without any persistent populations establishing. Under a hypothetico-deductive approach we would reject the null (prior) species distribution model as being useful, and seek to find a better one that can withstand the challenge of data.
Holistic evaluation in multi-model databases benchmarking
Authors: Zhang Chao , Lu Jiaheng 
Published: December 2019

AbstractA multi-model database (MMDB) is designed to support multiple data models against a single, integrated back-end. Examples of data models include document, graph, relational, and key-value. As more and more platforms are developed to deal with multi-model data, it has become crucial to establish a benchmark for evaluating the performance and usability of MMDBs. In this paper, we propose UniBench, a generic multi-model benchmark for a holistic evaluation of state-of-the-art MMDBs. UniBench consists of a set of mixed data models that mimics a social commerce application, which covers data models including JSON, XML, key-value, tabular, and graph. We propose a three-phase framework to simulate the real-life distributions and develop a multi-model data generator to produce the benchmarking data. Furthermore, in order to generate a comprehensive and unbiased query set, we develop an efficient algorithm to solve a new problem called multi-model parameter curation to judiciously control the query selectivity on diverse models. Finally, the extensive experiments based on the proposed benchmark were performed on four representatives of MMDBs: ArangoDB, OrientDB, AgensGraph and Spark SQL. We provide a comprehensive analysis with respect to internal data representations, multi-model query and transaction processing, and performance results for distributed execution.
The Ethic of Responsibility: Max Weber’s Verstehen and Shared Decision-Making in Patient-Centred Care
Authors: Hanemaayer Ariane 
Published: December 2019

AbstractWhereas evidence-based medicine (EBM) encourages the translation of medical research into decision-making through clinical practice guidelines (CPGs), patient-centred care (PCC) aims to integrate patient values through shared decision-making. In order to successfully integrate EBM and PCC, I propose a method of orienting physician decision-making to overcome the different obligations set out by a formally-rational EBM and substantively-rational ethics of care. I engage with Weber’s concepts “the ethic of responsibility” andverstehenas a new model of clinical reasoning that reformulates the relationship between medical knowledge and social values, while demonstrating the relevance of the classical sociological cannon to contemporary medical humanities.
The Resilience of EU Member States to the Financial and Economic Crisis
Authors: Alessi Lucia , Benczur Peter , Campolongo Francesca , Cariboni Jessica , Manca Anna Rita , Menyhert Balint , Pagano Andrea 
Published: December 2019

AbstractBased on the JRC conceptual framework for resilience (Manca et al. in Building a Scientific Narrative Towards a More Resilient EU Society, JRC Science for Policy Report, JRC28548, 2017), this study presents an empirical analysis of the resilience of EU Member States to the recent financial and economic crisis. We address two main research questions: (1) Which countries had a resilient outcome, in terms of both shock absorption during the crisis and recovery in its aftermath? (2) Are there pre-determined country characteristics that help to explain resilient performance? To address these questions, we first select 34 key indicators of economic performance and societal well-being, going well beyond the merely economic growth perspective. Resilience is then measured by the properties of the joint dynamic response of these variables to the crisis shock at different time horizons. Our results demonstrate substantial differences between countries in each of the resilience capacities considered. Regression analysis also reveals that certain predetermined characteristics—such as government expenditures on social protection, political stability or a favourable business environment—are strongly associated with resilient outcomes. Our methodology and findings offer lessons for monitoring resilience and for entry points for effective policy interventions in the future.
Factors associated with prolonged overall survival in patients with postmenopausal estrogen receptor-positive advanced breast cancer using real-world data: a follow-up analysis of the JBCRG-C06 Safari study
Authors: Kawaguchi Hidetoshi , Masuda Norikazu , Nakayama Takahiro , Aogi Kenjiro , Anan Keisei , Ito Yoshinori , Ohtani Shoichiro , Sato Nobuaki , Saji Shigehira , Takano Toshimi , Tokunaga Eriko , Nakamura Seigo , Hasegawa Yoshie , Hattori Masaya , Fujisawa Tomomi , Morita Satoshi , Yamaguchi Miki , Yamashita Hiroko , Yamashita Toshinari , Yamamoto Yutaka , Yotsumoto Daisuke , Toi Masakazu , Ohno Shinji 
Published: December 2019

Abstract
Background
Assessing survival risk is important for discussing treatment options with estrogen receptor-positive (ER+) advanced breast cancer (ABC) patients. However, there are few reports from large-scale databases on the survival risk factors in ER+ ABC. The Safari study (UMIN000015168) was a retrospective, multicenter cohort study involving 1072 Japanese patients receiving fulvestrant 500 mg mostly as a second- or later-line endocrine therapy for ER+ ABC. The follow-up data after the Safari study were examined, focusing on any relationship between clinicopathological factors and overall survival (OS) in ER+ ABC patients.

Methods
OS in patients with ER+ ABC was analyzed by univariate and multivariate analyses with a Cox proportional hazards model in this study.

Results
A total of 1031 cases were evaluable for OS analysis. Multivariate analysis showed that younger age (< 60 years), longer time from ABC diagnosis to fulvestrant use (≥ 3 years), no prior palliative chemotherapy before fulvestrant use, and progesterone receptor (PgR) negativity (PgR−) were significantly correlated with prolonged OS (median 7.0 years). For cases with histological or nuclear grade data, lower histological or nuclear grades were also correlated with longer OS. In recurrent metastatic cases, long disease-free interval (DFI) was not correlated with longer OS.

Conclusions
In ER+ ABC patients whose treatment history included fulvestrant, younger age, longer time from ABC diagnosis to fulvestrant use, no prior palliative chemotherapy use, PgR−, and lower histological or nuclear grade correlated positively with prolonged OS.
Nonlinear Z‐score modeling for improved detection of cognitive abnormality
Authors: Kornak John , Fields Julie , Kremers Walter , Farmer Sara , Heuer Hilary W. , Forsberg Leah , Brushaber Danielle , Rindels Amy , Dodge Hiroko , Weintraub Sandra , Besser Lilah , Appleby Brian , Bordelon Yvette , Bove Jessica , Brannelly Patrick , Caso Christina , Coppola Giovanni , Dever Reilly , Dheel Christina , Dickerson Bradford , Dickinson Susan , Dominguez Sophia , Domoto‐Reilly Kimiko , Faber Kelley , Ferrall Jessica , Fishman Ann , Fong Jamie , Foroud Tatiana , Gavrilova Ralitza , Gearhart Deb , Ghazanfari Behnaz , Ghoshal Nupur , Goldman Jill , Graff‐Radford Jonathan , Graff‐Radford Neill , Grant Ian M. , Grossman Murray , Haley Dana , Hsiao John , Hsiung Robin , Huey Edward D. , Irwin David , Jones David , Jones Lynne , Kantarci Kejal , Karydas Anna , Kaufer Daniel , Kerwin Diana , Knopman David , Kraft Ruth , Kramer Joel , Kukull Walter , Lapid Maria , Litvan Irene , Ljubenkov Peter , Lucente Diane , Lungu Codrin , Mackenzie Ian , Maldonado Miranda , Manoochehri Masood , McGinnis Scott , McKinley Emily , Mendez Mario , Miller Bruce , Multani Namita , Onyike Chiadi , Padmanabhan Jaya , Pantelyat Alexander , Pearlman Rodney , Petrucelli Len , Potter Madeline , Rademakers Rosa , Ramos Eliana Marisa , Rankin Katherine , Rascovsky Katya , Roberson Erik D. , Rogalski‐Miller Emily , Sengdy Pheth , Shaw Les , Staffaroni Adam M. , Sutherland Margaret , Syrjanen Jeremy , Tartaglia Carmela , Tatton Nadine , Taylor Joanne , Toga Arthur , Trojanowski John , Wang Ping , Wong Bonnie , Wszolek Zbigniew , Boeve Brad , Boxer Adam , Rosen Howard ,   ARTFL/LEFFTDS Consortium
Published: December 2019

AbstractIntroductionConventional Z‐scores are generated by subtracting the mean and dividing by the standard deviation. More recent methods linearly correct for age, sex, and education, so that these “adjusted” Z‐scores better represent whether an individual's cognitive performance is abnormal. Extreme negative Z‐scores for individuals relative to this normative distribution are considered indicative of cognitive deficiency.MethodsIn this article, we consider nonlinear shape constrained additive models accounting for age, sex, and education (correcting for nonlinearity). Additional shape constrained additive models account for varying standard deviation of the cognitive scores with age (correcting for heterogeneity of variance).ResultsCorrected Z‐scores based on nonlinear shape constrained additive models provide improved adjustment for age, sex, and education, as indicated by higher adjusted‐R2.DiscussionNonlinearly corrected Z‐scores with respect to age, sex, and education with age‐varying residual standard deviation allow for improved detection of non‐normative extreme cognitive scores.
The Role of Individual Risk Attitudes on Old Wine Valuations
Authors: Georgantzís Nikolaos , Tisserand Jean-Christian 
Published: December 2019

AbstractIn this article, we report the results of an experiment designed to address the effect of risk attitudes on valuations of aged wines. We find that higher risk taking in the economic domain is associated with a significantly higher willingness to pay for an old wine. Given the increasing interest of consumers and investors in old wines, our results are applicable to the pricing of old wines and to the use of auctions as an efficient willingness to pay elicitation mechanism. (JEL Classifications: C91, D44, L66)
Securing Social Security Solvency
Authors: Brandon William P. , Mohr Zachary 
Published: December 2019

AbstractAdequate income is a social determinant of health. In the United States, only Social Security beneficiaries receive inflation-protected guaranteed income. Social Security needs another 1983 compromise in which stakeholders accepted “shared pain” to avoid insolvency. We propose indexing the benefit using the chained consumer price index (CPI) for all urban consumers and providing a one-time bonus of 8% to 10% for beneficiaries in their mid-80s, when needs become greater. The chained CPI has little impact when beneficiaries start receiving benefits, but older beneficiaries need protection. The estimated 75-year savings from this restructured benefit amount to 14.2% to 18% of Social Security deficits. Modest increases in payroll taxes and maximum earnings taxed should make up most of the shortfall. Including unearned income with wages and salaries subject to the 6.2% individual tax would produce much more revenue. The discussion explores the proposal’s political feasibility, grounding in current policy and political science literature, and the role of income as a social determinant of health.
Biological approaches to public administration and public policy
Authors: Larimer Christopher W. , Peterson Steven A. 
Published: December 2019

AbstractThis special issue considers the relationship of the life sciences to both public policy and public administration. This makes sense because the bureaucratic process and public administration are deeply involved in the policy process and the development of substantive public policy. The two subjects are intertwined. And a biological perspective can illuminate many aspects of both. That is the focus of this issue.
Association of dietary acid load and plant-based diet index with sleep, stress, anxiety and depression in diabetic women
Authors: Daneshzad Elnaz , Keshavarz Seyed-Ali , Qorbani Mostafa , Larijani Bagher , Bellissimo Nick , Azadbakht Leila 
Published: December 2019

AbstractDiabetes is a common chronic disease with various complications. The present study was conducted to determine the association of plant-based diet index (PDI) and dietary acid load (DAL) with sleep status as well as mental health in type 2 diabetic women. In this cross-sectional study, a validated FFQ was used to assess dietary intakes of 230 diabetic patients. We created a whole PDI, healthful PDI (hPDI) and unhealthful PDI (uPDI). DAL was calculated based on potential renal acid load and net endogenous acid production method. The Pittsburgh Sleep Quality Index and twenty-one-item Depression, Anxiety and Stress Scale were used to assess sleep and mental health disorders, respectively. Participants in the top group of uPDI had greater risk of poor sleep (OR 6·47, 95 % CI 2·75, 15·24). However, patients who were in the top group of hPDI had a lower risk of sleep problems (OR 0·28, 95 % CI 0·13, 0·62). Participants in the top group of uPDI had greater risk of depression, anxiety and stress (OR 9·35, 95 % CI 3·96, 22·07; OR 4·74, 95 % CI 2·28, 9·85; OR 4·24, 95 % CI 2·14, 8·38, respectively). In conclusion, participants with higher DAL scores and patients who adhered to animal-based diets rather than plant-based diets were more likely to be poor sleepers and have mental health disorders.
Has the long-predicted decline in consanguineous marriage in India occurred?
Authors: Kumari Nutan , Bittles Alan H. , Saxena Prem 
Published: December 2019

AbstractTo an extent the question posed in the title of this paper can simply be answered in the affirmative. Based on the extensive data available from the National Family Health Survey-1 (NFHS-1) conducted in 1992–93 and NFHS-4 in 2015–16 there has been a significant overall decline of some 19% in the prevalence of consanguineous marriage in India. However, when examined at state level the picture is more complex, with large reductions in consanguinity in southern states where intra-familial marriage previously has been strongly favoured, whereas in some northern states in which close kin unions traditionally have been proscribed small increases were recorded. In a country such as India, comprising an estimated 18% of the current world population and with multiple ethnic, religious, geographical and social sub-divisions, apparently contrary findings of this nature are not unexpected – especially given the major shifts that are underway in family sizes, in education and employment, and with rapid urbanization. The changing health profile of the population also is an important factor, with non-communicable diseases now responsible for a majority of morbidity and premature mortality in adulthood. The degree to which future alterations in the prevalence and profile of consanguineous marriage occur, and at what rate, is difficult to predict – the more so given the markedly diverse cultural identities that remain extant across the Sub-Continent, and ongoing intra-community endogamy.
A longitudinal study of maternal interaction strategies during joint book-reading in Taiwan
Authors: CHANG Chien-Ju , LUO Ya-Hui 
Published: December 2019

AbstractThis longitudinal study examines change in maternal interaction strategies in Taiwanese mothers across time, and the synchronic and diachronic relationships between maternal interaction strategies and children's language and early literacy skills. Forty-two mother–child dyads participated in this study. Their interactions during joint book-reading were tape-recorded, transcribed, and analyzed when the children were fourteen, twenty-six, and thirty-six months of age. The children received a battery of language and early literacy tests when they were thirty-six months old. Findings showed that Taiwanese mothers adjusted their use of interaction strategies as their children grew. Maternal use of description, performance, prediction inference, and print-related talk were positively correlated with their children's language and literacy skills. Significant negative correlations were found between use of task-behavioral regulation strategy and text reading in mothers and their children's language performance. This study suggests that age-appropriate interaction strategies are important for children's language and early literacy development.
Comparing Resource Management Skills in a High- versus Low-Resource Simulation Scenario: A Pilot Study
Authors: Ripoll Gallardo Alba , Meneghetti Grazia , Franc Jeffrey M. , Costa Alessandro , Ragazzoni Luca , Bodas Moran , Jordan Vaclav , Della Corte Francesco 
Published: December 2019

AbstractBackground:Low-resource environments, such as those found in humanitarian crises, pose significant challenges to the provision of proper medical treatment. While the lack of training of health providers to such settings has been well-acknowledged in literature, there has yet to be any scientific evidence for this phenomenon.Methods:This pilot study utilized a randomized crossover experimental design to examine the effects of high- versus low-resource simulated scenarios of a resuscitation of a critically ill obstetric patient on a medical doctors’ performance and inter-personal skills. Ten senior residents (fifth-year post-graduate) of the Maggiore Hospital School of Medicine (Novara, NO, Italy) were included in the study.Results:Overall performance score for the high-resource setting was 5.2, as opposed to only 2.3 for the low-resource setting. The mean effect size for the overall score was 2.9 (95% CI, 1.7–4.0; P <.001). The results suggest a significant decrease in both technical (medical) and non-technical skills, such as leadership, problem solving, situation awareness, resource utilization, and communication in the low-resource environment setting. The latter finding is of special important since it was yet to be reported.Conclusions:This pilot study suggests that untrained physicians in low-resource environments may experience a considerable setback not only to their professional performance, but also to their interpersonal skills, when deployed ill-prepared to humanitarian missions. Consequently, this may endanger the health of local populations.
Young adult nutrition and weight correlates of picky eating during childhood
Authors: Pesch Megan H , Bauer Katherine W , Christoph Mary J , Larson Nicole , Neumark-Sztainer Dianne 
Published: December 2019

AbstractObjective:To identify whether picky eating during childhood is associated with dietary intake, weight status and disordered eating behaviour during young adulthood.Design:A population-based study using data from young adults who responded online or by mail to the third wave of the Project EAT (Eating and Activity in Teens and Young Adults) study in 2008–2009. Participants retrospectively reported the extent to which they were a picky eater in childhood, sociodemographic characteristics, disordered eating behaviours, usual dietary intake, and weight and height.Setting:Participants were initially recruited in the Minneapolis/St. Paul metropolitan area of Minnesota, USA, in 1998–1999.Participants:The analytic sample included 2275 young adults (55 % female, 48 % non-Hispanic White, mean age 25·3 (sd 1·6) years).Results:Young adults who reported picky eating in childhood were found to currently have lower intakes of fruit, vegetables and whole grains, and more frequent intakes of snack foods, sugar-sweetened beverages and foods from fast-food restaurants. No associations were observed between picky eating in childhood and young adults’ weight status, use of weight-control strategies or report of binge eating.Conclusions:While young adults who report picky eating during childhood are not at higher risk for disordered eating, those who were picky eaters tend to have less healthy dietary intake. Food preferences and dietary habits established by picky eaters during childhood may persist into adulthood.