bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of survival outcomes in sinonasal squamous cell carcinoma: an analysis of the National Cancer Database
Authors: Farrell Nyssa Fox , Mace Jess C. , Detwiller Kara Y. , Li Ryan , Andersen Peter E. , Smith Timothy L. , Clayburgh Daniel R. , Geltzeiler Mathew 
Published: November 2020

BackgroundSinonasal squamous cell carcinoma (SNSCC) is a rare malignancy that poses management challenges. Although surgery and chemoradiation therapy (CRT) remain therapeutic mainstays, induction chemotherapy (IC) has emerged as a useful adjunct with locally advanced disease. This study used the National Cancer Data Base (NCDB) to examine treatment outcomes for patients diagnosed with SNSCC.MethodsThe NCDB (2004‐2015) was queried for cases with SNSCC. Multivariate hazard regression modeling was used to identify significant predictors of 24‐month and 60‐month overall survival (OS) including treatment modality.ResultsA total of 3516 patients with SNSCC met inclusion criteria, including 1750 patients (49.8%) treated with surgery ± adjuvant therapy, 1352 (38.5%) treated with definitive radiotherapy (RT) or CRT, 300 (8.5%) who underwent IC followed by definitive CRT, and 114 (3.2%) who received IC followed by surgery and adjuvant therapy. Hazard modeling for confirmed treatment modality significantly associated (p < 0.001) with OS after adjustment. Patients who received surgical intervention ± adjuvant therapy had lower 24‐month and 60‐month mortality risk compared to definitive RT or CRT (hazard ratio [HR] ≥ 1.97; p < 0.001) or IC followed by definitive CRT (HR ≥ 1.73; p < 0.001). Compared to primary surgery ± adjuvant therapy, patients undergoing IC then surgery had similar 24‐month and 60‐month OS (p ≥ 0.672) after adjustment.ConclusionMultimodality therapy, including surgical intervention, associates with improved OS after multifactorial adjustments. IC followed by surgery associated with improved OS compared to IC, followed by CRT and CRT alone. Study results highlight the utility of surgery toward optimizing OS in patients with SNSCC and demonstrates the potential utility of IC when primary surgical management is not preferred.
Dominantly inherited Alzheimer's disease in Latin America: Genetic heterogeneity and clinical phenotypes
Authors: Llibre‐Guerra Jorge J. , Li Yan , Allegri Ricardo F. , Mendez Patricio Chrem , Surace Ezequiel I. , Llibre‐Rodriguez Juan J. , Sosa Ana Luisa , Aláez‐Verson Carmen , Longoria Erika‐Mariana , Tellez Alberto , Carrillo‐Sánchez Karol , Flores‐Lagunes Luis Leonardo , Sánchez Victor , Takada Leonel Tadao , Nitrini Ricardo , Ferreira‐Frota Norberto Anizio , Benevides‐Lima Joyce , Lopera Francisco , Ramírez Laura , Jiménez‐Velázquez Ivonne , Schenk Christian , Acosta Daisy , Behrens María Isabel , Doering Michelle , Ziegemeier Ellen , Morris John C. , McDade Eric , Bateman Randall J. 
Published: November 2020

AbstractIntroductionA growing number of dominantly inherited Alzheimer's disease (DIAD) cases have become known in Latin American (LatAm) in recent years. However, questions regarding mutation distribution and frequency by country remain open.MethodsA literature review was completed aimed to provide estimates for DIAD pathogenic variants in the LatAm population. The search strategies were established using a combination of standardized terms for DIAD and LatAm.ResultsTwenty‐four DIAD pathogenic variants have been reported in LatAm countries. Our combined dataset included 3583 individuals at risk; countries with highest DIAD frequencies were Colombia (n = 1905), Puerto Rico (n = 672), and Mexico (n = 463), usually attributable to founder effects. We found relatively few reports with extensive documentation on biomarker profiles and disease progression.DiscussionFuture DIAD studies will be required in LatAm, albeit with a more systematic approach to include fluid biomarker and imaging studies. Regional efforts are under way to extend the DIAD observational studies and clinical trials to Latin America.
Alzheimer's team care approach—akin to diabetes—in the development, validation, and population assessment of retinal biomarkers for disease
Authors: Dueñas Michael R. , Snyder Peter J. 
Published: November 2020

AbstractThere exists a public health imperative to discover and to develop disease‐modifying Alzheimer's disease (AD) therapeutics to protect the health of millions of individuals facing AD. Achievement of this goal will be dependent on developing the clinical tools to detect high risk, in the earliest phases of the disease, and at the population level. This article describes the study of retinal biomarkers for the identification of, and tracking of change over time for, individuals in the preclinical stage of AD and substantiates the need for a major cross‐disciplinary effort for comparison across labs and clinical sites using diabetes risk monitoring as a perfect analogy. Proposed framework would: (1) support AD working groups across disciplines; (2) establish common imaging platforms to develop and test basic standards, and minimum datasets to embrace and test novel innovations as they emerge; and (3) accelerate AD prevention and quality improvement in real‐world care.
Selbstregeneration und Selbstheilung in DNA‐Origami‐Nanostrukturen
Authors: Scheckenbach Michael , Schubert Tom , Forthmann Carsten , Glembockyte Viktorija , Tinnefeld Philip 
Published: November 2020

AbstractDNA‐Nanotechnologie und Fortschritte in der DNA‐Origami‐Technik haben das einfache Design und die Synthese komplexer und funktioneller Nanostrukturen ermöglicht. Jedoch sind molekulare Geräte aufgrund des hohen Anteils von Oberflächenatomen und der komplexen Einsatzbedingungen im Nanomaßstab anfällig für eine schnelle funktionelle und strukturelle Degradierung. Neben Stabilisierungsmechanismen sind Ansätze zur Selbstreparatur funktioneller molekularer Geräte wünschenswert. Hier nutzen wir die selbst‐assemblierenden und rekonfigurierbaren Eigenschaften von DNA‐Origami‐Nanostrukturen für die Selbstreparatur von photoinduzierten und enzymatischen Schäden aus. Wir geben Beispiele für die Reparatur von DNA‐Nanostrukturen, die den Unterschied zwischen unspezifischer Selbstregeneration und schadensspezifischer Selbstheilung aufzeigen. Anhand von DNA‐Origami‐Nanolinealen, die mit Rasterkraftmikroskopie und DNA‐PAINT‐Superauflösungs‐Mikroskopie untersucht wurden, demonstrieren wir die quantitative Aufrechterhaltung der Fluoreszenzeigenschaften mit direktem Potenzial zur Verbesserung nanoskaliger Kalibrierproben.
Copper(I)‐Catalyzed Asymmetric Interrupted Kinugasa Reaction: Synthesis of α‐Thiofunctional Chiral β‐Lactams
Authors: Qi Jialin , Wei Fang , Huang Shuai , Tung Chen‐Ho , Xu Zhenghu 
Published: November 2020

AbstractA copper(I)‐catalyzed asymmetric, three‐component interrupted Kinugasa reaction has been developed. Diverse chiral sulfur‐containing chiral β‐lactams with two consecutive stereogenic centers were synthesized in one step from readily available starting materials in good yields and with excellent diastereo‐ and enantioselectivity. The key is the interception of in situ formed chiral four membered copper(I) enolate intermediate with sulfur electrophiles.
2,4,6‐Triphenylpyridinium: A Bulky, Highly Electron‐Withdrawing Substituent That Enhances Properties of Nickel(II) Ethylene Polymerization Catalysts
Authors: Janeta Mateusz , Heidlas Julius X. , Daugulis Olafs , Brookhart Maurice 
Published: November 2020

AbstractThe reactivity of NiII and PdII olefin polymerization catalysts can be enhanced by introduction of electron‐withdrawing substituents on the supporting ligands rendering the metal centers more electrophilic. Reported here is a comparison of ethylene polymerization activity of a classical salicyliminato nickel catalyst substituted with the powerful electron‐withdrawing 2,4,6‐triphenylpyridinium (trippy) group to the ‐CF3 analogue. The trippy substituent is substantially more electron‐withdrawing (σmeta=0.63) than the trifluoromethyl group (σmeta=0.43) which results in a ca. 8‐fold increase in catalytic turnover frequency. An additional advantage of trippy is the high steric bulk relative to the trifluoromethyl group. This feature results in a four‐fold increase in polymer molecular weight owing to enhanced retardation of chain transfer. A significant increase in catalyst lifetime is observed as well.
Highly Potent MRI Contrast Agent Displaying Outstanding Sensitivity to Zinc Ions
Authors: Wang Gaoji , Angelovski Goran 
Published: November 2020

AbstractZinc ions play an important role in numerous crucial biological processes in the human body. The ability to image the function of Zn2+ would be a significant asset to biomedical research for monitoring various physiopathologies dependent on its fate. To this end, we developed a novel Gd3+ chelate that can selectively recognize Zn2+ over other abundant endogenous metal ions and alter its paramagnetic properties. More specifically, this lanthanide chelate displayed an extraordinary increase in longitudinal relaxivity (r1) of over 400 % upon interaction with Zn2+ at 7 T and 25 °C, which is the greatest r1 enhancement observed for any of the metal ion‐responsive Gd‐based complexes at high magnetic field. A “turn‐on” mechanism responsible for these massive changes was confirmed through NMR and luminescence lifetime studies on a 13C‐labeled Eu3+ analogue. This molecular platform represents a new momentum in developing highly suitable magnetic resonance imaging contrast agents for functional molecular imaging studies of Zn2+.
Self‐Regeneration and Self‐Healing in DNA Origami Nanostructures
Authors: Scheckenbach Michael , Schubert Tom , Forthmann Carsten , Glembockyte Viktorija , Tinnefeld Philip 
Published: November 2020

AbstractDNA nanotechnology and advances in the DNA origami technique have enabled facile design and synthesis of complex and functional nanostructures. Molecular devices are, however, prone to rapid functional and structural degradation due to the high proportion of surface atoms at the nanoscale and due to complex working environments. Besides stabilizing mechanisms, approaches for the self‐repair of functional molecular devices are desirable. Here we exploit the self‐assembly and reconfigurability of DNA origami nanostructures to induce the self‐repair of defects of photoinduced and enzymatic damage. We provide examples of repair in DNA nanostructures showing the difference between unspecific self‐regeneration and damage specific self‐healing mechanisms. Using DNA origami nanorulers studied by atomic force and superresolution DNA PAINT microscopy, quantitative preservation of fluorescence properties is demonstrated with direct potential for improving nanoscale calibration samples.
Biocompatible heterogeneous bone incorporated with polymeric biocomposites for human bone repair by 3D printing technology
Authors: Wan Meiling , Liu Shuifeng , Huang Da , Qu Yang , Hu Yang , Su Qisheng , Zheng Wenxu , Dong Xianming , Zhang Hongwu , Wei Yen , Zhou Wuyi 
Published: November 2020

AbstractPolylactic acid (PLA) has become a popular polymer material due to its superior biocompatibility. At present, there are a few relevant research on heterogeneous bone powder. Besides, the poor dispersibility and adhesivity of inorganic particles in the organic phase remains a problem. In this study, the pork bone powders were modified with N‐butanol to improve its dispersibility and compatibility in the PLA matrix. In addition, polybutylene succinate‐co‐terephthalates (PBSA) was applied as a flexibilizer to further reinforce the mechanical properties of materials. The composite filaments with a diameter of 1.75 ± 0.05 mm containing 10 wt% of modified bone powder, 10 wt% PBSA and 80 wt% PLA were prepared by a melt blending method. The obtained results showed that modified particles were uniformly dispersed within the PLA matrix and improved the mechanical properties of the composite filaments with a tensile strength of 48.5 ± 0.2 MPa and a bending strength of 79.1 ± 0.1 MPa and a notch impact strength of 15.8 ± 0.3 kJ/m2. And the prepared composite materials contained low cytotoxicity, high biocompatibility and printability, which verified the feasibility of it in 3D printing personalized bone repair applications. This provides a theoretical basis for further research on the effect of bone repair in vivo. Therefore, the composite material will have potential applications such as making customized bones and bone scaffolds by three dimensional printing technology.
Maternal diabetes‐related malformations inUtah: A population study of birth prevalence 2001–2016
Authors: Orbain Matthew M. , Johnson Jane , Nance Amy , Romeo Alfred N. , Silver Michelle A. , Martinez Lynn , Leen‐Mitchell Marsha , Carey John C. 
Published: November 2020

AbstractMaternal pregestational diabetes mellitus is associated with an increased risk for congenital malformations of about 2–4 times the background risk. Notably, the types and patterns of congenital malformations associated with maternal diabetes are nonrandom, with a well‐established increased risk for specific classes of malformations, especially of the heart, central nervous system, and skeleton. While the increased risk in clinical and epidemiological studies is well documented in the literature, a precise estimate of overall birth prevalence of these specific congenital malformations among women with maternal pregestational diabetes, is lacking. The purpose of this study was to determine total prevalence of structural malformations associated with maternal pregestational diabetes mellitus in a population‐based study. We identified infants with specific birth defects whose mother had pregestational diabetes mellitus in the Utah Birth Defect Network (UBDN), an active birth defects surveillance program that registers the occurrence of selected structural defects in the state of Utah. We defined specific maternal diabetes‐related malformations based on epidemiologic and clinical studies in the literature. Of the 825,138 recorded Utah births between 2001 and 2016, a total of 91 cases were identified as likely having diabetic embryopathy within UBDN data. The prevalence of diabetes‐related congenital malformation cases was calculated per year; the overall prevalence of diabetes‐related malformations 2001–2016 was 1.1 per 10,000 births in Utah (95% CI, 0.9–1.3). Knowledge of the overall prevalence of diabetes‐related malformations is important in predicting the number of cases that are potentially prevented with the implementation of programs to foster preconceptional management of maternal pregestational diabetes.
A methodological review of preference displacement research
Authors: White Allison N. , Melanson Isaac J. , Sipila‐Thomas Emma S. , Brodhead Matthew T. 
Published: November 2020

AbstractThe purpose of this review was to identify and compare methodological components of preference displacement research and outcomes. We coded, categorized, and defined patterns of preference displacement for a total of 133 participants across 10 studies. We found that patterns of displacement differed within and across studies, and over 46% of participants did not engage in patterns of displacement. Therefore, the commonly held notion that edible stimuli are more likely to displace tangible stimuli is not as ubiquitous as once thought. However, due to considerable variation in methodology and reporting across reviewed studies, it is difficult to determine what variables may be responsible for obtained study outcomes. We conclude that future researchers consider the importance of each methodological variable coded in our review, and make methodological decisions in the context of the research question they are looking to answer. We also provide additional suggestions for future research and clinical practice.
Application of supercritical fluid chromatography for separation and quantitation of 15 co‐formulated binary anti‐hypertensive medications using a single elution protocol
Authors: Pandya Pranav A. , Shah Priyanka A. , Shrivastav Pranav S. 
Published: November 2020

AbstractA facile supercritical fluid chromatography method is proposed to analyse 15 co‐formulated binary anti‐hypertensive drug combinations using a customized elution procedure. The effect of mobile phase composition, column back pressure and temperature was suitably optimized for adequate retention, analyte response and resolution. The chromatographic separation of the different drug combinations was performed on a DCPak poly(4‐vinylpyridine) column (250 × 4.6 mm, 5 μm) at 125‐bar pressure and 40°C using a photodiode array detector. A linear gradient of CO2 and 0.1% formic acid in methanol provided the best elution conditions for all drug combinations. Baseline separation of the drugs was possible with resolution factor Rs ranging from 1.42 to 12.58. The method was validated for specificity, sensitivity, accuracy and precision, recovery and robustness. The limit of detection and limit of quantitation for aliskiren, amlodipine, atenolol, candesartan, hydrochlorothiazide, lisinopril, losartan, metoprolol, olmesartan, telmisartan and valsartan were in the range of 0.26–2.56 and 0.77–7.75 μg/mL, respectively. The thermodynamic study revealed that interactions of the drugs with the stationary phase were spontaneous as evident from the negative free energy values, and the separation process was enthalpy driven. The developed method was successfully employed to analyse these drugs in their co‐formulated tablet formulations.
Longitudinal changes in anxiety and psychological distress, and associated risk and protective factors during the first three months of the COVID‐19 pandemic in Germany
Authors: Bendau Antonia , Plag Jens , Kunas Stefanie , Wyka Sarah , Ströhle Andreas , Petzold Moritz Bruno 
Published: November 2020

AbstractBackgroundThe COVID‐19 pandemic is related to multiple stressors and therefore may be associated with psychological distress. The aim of this study was to longitudinally assess symptoms of (un‐)specific anxiety and depression along different stages of the pandemic to generate knowledge about the progress of psychological consequences of the pandemic and to test the role of potential risk and resilience factors that were derived from cross‐sectional studies and official recommendations.MethodsThe present study uses a longitudinal observational design with four waves of online data collection (from March 27 to June 15, 2020) in a convenience sample of the general population in Germany. A total of N = 2376 participants that completed at least two waves of the survey were included in the analyses.FindingsSpecific COVID‐19‐related anxiety and the average daily amount of preoccupation with the pandemic decreased continuously over the four waves. Unspecific worrying and depressive symptoms decreased on average but not on median level. Self‐efficacy, normalization, maintaining social contacts, and knowledge, where to get medical support, were associated with fewer symptoms relative to baseline. Suppression, unhealthy habits, and a longer average daily time of thinking about the pandemic were correlated with a relative increase of symptoms.InterpretationOur findings provide insight into the longitudinal changes of symptoms of psychological distress along the first three months of the COVID‐19 pandemic in Germany. Furthermore, we were able to reaffirm the anticipated protective and risk factors that were extracted from previous studies and recommendations.
Engineering through distance education in the time of the fourth industrial revolution: Reflections from three decades of peer reviewed studies
Authors: Kocdar Serpil , Bozkurt Aras , Goru Dogan Tulay 
Published: November 2020

AbstractIn this current era of the fourth industrial revolution, the fifth generation of distance education has held out hopes of unique opportunities for engineering. With the aim of investigating the field of engineering through distance education, this study conducted a systematic review involving text‐mining and social network analysis to examine 120 publications on this topic. The time trend analysis found that there has been a steadily increasing interest in engineering through distance education. Analysis of subject areas revealed that a considerable amount of the publications on engineering through distance education falls under the social sciences subject area, suggesting that there is a need for more interdisciplinary studies. In examining the geographical distribution of the publications, it was observed that most contributions come from the United States, a developed country that has invested heavily in educating students through distance education. The research patterns identified through text‐mining and social network analysis revealed three major themes: (I) technology‐enhanced distance engineering education, (II) e‐learning and m‐learning, and (III) virtual and remote labs.
Highly Effective Direct Dehydrogenation of Propane to Propylene by Microwave Catalysis at Low Temperature over Co−Sn/NC Microwave Catalyst
Authors: Wang Qige , Xu Wentao , Ma Zhongchen , Yu Fei , Chen Yi , Liao Huanyu , Wang Xianyou , Zhou Jicheng 
Published: November 2020

AbstractThe direct catalytic dehydrogenation of propane (C3H8) to value‐added propylene (C3H6) has attracted much attention. However, direct dehydrogenation of C3H8 to C3H6 with outstanding catalytic performance at low temperature is a great challenge. Herein, we report a new approach for the direct dehydrogenation of C3H8 to C3H6 at low temperature by microwave catalysis over non‐precious Co−Sn/NC microwave catalyst. It is found that the microwave direct catalytic dehydrogenation of C3H8 over Co−Sn/NC microwave catalyst at low temperature (450 °C) is highly efficient. The C3H8 conversion is 15 % and the C3H6 selectivity is 75 % at 450 °C. Comparatively, the C3H8 conversion and C3H6 selectivity were respectively only 3.2 % and 67.8 % for Co−Sn/NC catalyst at 450 °C in the conventional reaction mode under identical conditions. Furthermore, the microwave catalyst does not show visible change after tested for 180 min. Importantly, the apparent activation energy of Co−Sn/NC catalyst drop from 59.58 kJ/mol in the conventional reaction mode to 20.98 kJ/mol in microwave catalytic reaction mode, which suggests a significant microwave direct catalytic effect. This work provides a novel approach for highly effective direct dehydrogenation of C3H8 to C3H6 by microwave irradiation at low temperature.
Supercritical Process for Preparation of Nanomedicine: Oxaprozin Case Study
Authors: Khoshmaram Aliakbar , Zabihi Samyar , Pelalak Rasool , Pishnamazi Mahboubeh , Marjani Azam , Shirazian Saeed 
Published: November 2020

AbstractThe solubility of oxaprozin was determined in supercritical carbon dioxide as solvent under different temperatures and pressures using the gravimetric technique. The measured solubility data revealed that the solubility of this medication varies by changing the pressure and temperature. The oxaprozin/supercritical solvent possesses a crossover pressure at 200 bar where the influence of temperature on the solubility changes. Furthermore, the experimental data was correlated using several semi‐empirical models. The best result was stated for the Kumar and Johnston model, whereas the other examined models introduced higher deviations.