bluuebunny/crossref_metadata_2025_split huggingface dataset:
ACOUSTICAL STANDARDS NEWS
Authors: Blair-DeLeon Nancy A. , Struck Christopher J. 
Published: October 2020

American National Standards (ANSI Standards) developed by Accredited Standards Committees S1, S2, S3, S3/SC 1, and S12 in the areas of acoustics, mechanical vibration and shock, bioacoustics, animal bioacoustics, and noise, respectively, are published by the Acoustical Society of America (ASA). In addition to these standards, ASA publishes a catalog of Acoustical American National Standards. To browse the latest copy of our catalog, visit our website at https://acousticalsociety.org/download-catalog/.
Comments are welcomed on all material in Acoustical Standards News.
This Acoustical Standards News section in JASA, as well as the National Catalog of Acoustical Standards and other information on the Standards Program of the Acoustical Society of America, are also available via the ASA Standards home page: https://acousticalsociety.org/acoustical-society-standards/.
Exploring the Possibilities of Outdoor/Adventure Education
Authors: Griffin Kent 
Published: October 2020

Physical education in recent years has undergone modifications in order to meet the changing demands of students. The traditional paradigm has been to teach physical education from a sport- and skill-based approach, whereby traditional teams and individual sports are emphasized (e.g., basketball, volleyball, flag football). However, this curriculum may be less impactful on student learning than alternatives and is not viewed favorably by administrators because it is perceived as lacking relevance to broader educational goals. The purpose of this paper was to reintroduce a curriculum that has the potential to address student learning in physical education and broader educational goals. The outdoor/adventure education curriculum, while neglected in recent years, is demonstrating promising gains as a viable model.
Seismicity and active faulting associated with the North America–Caribbean plate boundary in Chiapas, Mexico: A review
Authors: Guzmán-Speziale* Marco , Meneses-Rocha Javier 
Published: October 2020

ABSTRACT
We present a summary of information on seismically active faulting in Chiapas, Mexico, related to North America–Caribbean plate-boundary zone deformation. We collected data from published works, and we also present new data collected from reporting agencies. Several active structures were identified as part of the deformation of the plate-boundary zone in the states of Chiapas and Veracruz, including 18 large (up to 175-km-long) strike-slip faults belonging to three tectonic realms: the Tonalá realm, the Depresión Central, and the strike-slip fault province. Available fault-plane solutions indicate left-lateral, strike-slip displacement along these faults. The reverse-fault province is also found to be part of the plate-boundary zone and seismically active, with thrust-faulting fault-plane solutions. Deformation extends to the northwest, along the Veracruz coastal plains region, which is also seismically active.
Cenozoic tectonic evolution of the Ecemiş fault zone and adjacent basins, central Anatolia, Turkey, during the transition from Arabia-Eurasia collision to escape tectonics
Authors: Umhoefer Paul J. , Thomson Stuart N. , Lefebvre Côme , Cosca Michael A. , Teyssier Christian , Whitney Donna L. 
Published: October 2020

Abstract
The effects of Arabia-Eurasia collision are recorded in faults, basins, and exhumed metamorphic massifs across eastern and central Anatolia. These faults and basins also preserve evidence of major changes in deformation and associated sedimentary processes along major suture zones including the Inner Tauride suture where it lies along the southern (Ecemiş) segment of the Central Anatolian fault zone. Stratigraphic and structural data from the Ecemiş fault zone, adjacent NE Ulukışla basin, and metamorphic dome (Niğde Massif) record two fundamentally different stages in the Cenozoic tectonic evolution of this part of central Anatolia. The Paleogene sedimentary and volcanic strata of the NE Ulukışla basin (Ecemiş corridor) were deposited in marginal marine to marine environments on the exhuming Niğde Massif and east of it. A late Eocene–Oligocene transpressional stage of deformation involved oblique northward thrusting of older Paleogene strata onto the eastern Niğde Massif and of the eastern massif onto the rest of the massif, reburying the entire massif to &gt;10 km depth and accompanied by left-lateral motion on the Ecemiş fault zone. A profound change in the tectonic setting at the end of the Oligocene produced widespread transtensional deformation across the area west of the Ecemiş fault zone in the Miocene. In this stage, the Ecemiş fault zone had at least 25 km of left-lateral offset. Before and during this faulting episode, the central Tauride Mountains to the east became a source of sediments that were deposited in small Miocene transtensional basins formed on the Eocene–Oligocene thrust belt between the Ecemiş fault zone and the Niğde Massif. Normal faults compatible with SW-directed extension cut across the Niğde Massif and are associated with a second (Miocene) re-exhumation of the Massif. Geochronology and thermochronology indicate that the transtensional stage started at ca. 23–22 Ma, coeval with large and diverse geological and tectonic changes across Anatolia.
The Mass Knee Clinic: a new NHS outpatient care model showing clinically led transformation in practice
Authors: Li Lily , Nahas Sam , Jandoo Rajan , Williams Sarah , Lionel Ganippa Haddon Paul , Bhattacharya Rajarshi , Nathwani Dinesh 
Published: October 2020

Background
The Mass Knee Clinic is an innovative, patient-focused and efficient clinic introduced into our hospital in April 2017. The UK Government has mandated referral-to-treatment (RTT) time for patients to be within 18 weeks to improve patient care. The new clinic involves seeing high numbers of patients by amalgamating all new non-traumatic knee disorders (up to 200) from primary care into one clinic day every 6 weeks. The premise and success of the clinic is multifactorial and involves focused multidisciplinary consultant-led care in every case, training opportunities for junior doctors, a ‘one-stop shop’ for patients allowing them to be seen by a consultant, physiotherapist and receive a date for surgery all in 1 day, and subspeciality consultant presence, preventing multiple reattendances.

Methods
We present the results of prospectively collected data on wait times to clinic, time-to-treatment and outsourcing of new referrals, 1 year after the initiation of the new clinic model (n=56). This data was compared with data 1 year prior to the Mass Clinic being introduced (n=56).

Results
Time from primary care referral to first Orthopaedic review was reduced from median 13.5 weeks to 11 weeks (statistically significant (p=0.00512)). RTT was reduced from median 30.5 weeks to 15.5 weeks (p<0.01), allowing a significant reduction in waiting times for the patient. Outsourcing was eliminated, and the number of appointments per patient also halved.

Conclusions
The new Mass Clinic with focused consultant-led care and multidisciplinary approach has led to significant reductions in patient wait times and cost savings for the hospital.
Prognostic and clinicopathological significance of pretreatment mean platelet volume in cancer: a meta-analysis
Authors: Chen Xin , Li Jing , Zhang Xunlei , Liu Yushan , Wu Jindong , Li Yangcheng , Cui Xiaopeng , Jiang Xiaohui 
Published: October 2020

ObjectiveOur study aimed to evaluate the prognostic and clinicopathological significance of pretreatment mean platelet volume (MPV) on cancer by using meta-analysis of published studies.DesignMeta-analysis.Data sourcesRelevant studies available before 22 December 2019 were identified by searching MEDLINE, EMBASE.Eligibility criteriaAll published studies that assessed the prognostic and clinicopathological significance of pretreatment MPV on cancer were included.Data extraction and synthesisStudies were identified and extracted by two reviewers independently. The HR/OR and its 95% CIs of survival outcomes and clinicopathological parameters were calculated.ResultsA total of 38 eligible studies (41 subsets) with 9894 patients with cancer were included in the final meta-analysis. MPV level was not significantly associated with both overall survival (HR 0.98, 95% CI 0.84 to 1.14) and disease-free survival (HR 1.22, 95% CI 0.86 to 1.73) of patients with cancer. Neither advanced nor mixed-stage tumour patients showed significant association between MPV and overall survival (HR 1.36, 95% CI 0.96 to 1.94, HR 0.90, 95% CI 0.74 to 1.09). However, high MPV had the strongest relationship with poor overall survival (HR 2.01; 95% CI 1.08 to 3.41) in gastric cancer, followed by pancreatic cancer (HR 1.54; 95% CI 1.31 to 1.82). Whereas in the subgroup using receiver operating characteristic curve method to define cut-off values, low MPV was significantly related to poor overall survival (HR 0.78, 95% CI 0.64 to 0.95). In addition, MPV had no significant association with age (OR 0.96, 95% CI 0.90 to 1.02), sex (OR 1.04, 95% CI 1.00 to 1.09), depth of cancer invasion (OR 0.90, 95% CI 0.77 to 1.04) and tumour stage (OR 0.91, 95% CI 0.78 to 1.07).ConclusionsPretreatment MPV level is of no clearly prognostic significance in cancers and no significant association with clinicopathological parameters of patients with cancers.
Factors influencing maternal health in indigenous communities with presence of traditional midwifery in the Americas: protocol for a scoping review
Authors: Sarmiento Iván , Paredes-Solís Sergio , Morris Martin , Pimentel Juan , Cockcroft Anne , Andersson Neil 
Published: October 2020

IntroductionIndigenous mothers often receive culturally unsafe services that do not fully respond to their needs. The objective of this scoping review is to collate and assess evidence that identifies factors, including the role and influence of traditional midwives, that affect maternal health in indigenous communities in the Americas. The results will map Western perspectives reflected in published and unpublished literature to indicate the complex network of factors that influence maternal outcomes. These maps will allow for comparison with local stakeholder knowledge and discussion to identify what needs to change to promote culturally safe care.Methods and analysisA librarian will search studies with iterative and documented adjustments in CINAHL, Scopus, Latin American and Caribbean Health Sciences Literature (LILACS), MEDLINE, Embase and Google Scholar without any time restrictions, and use Google search engine for grey literature. Included studies will be empirical (quantitative, qualitative or mixed); address maternal health issues among indigenous communities in the Americas; and report on the role or influence of traditional midwives. Two researchers will independently screen and blindly select the included studies. The quality assessment of included manuscripts will rely on the Mixed Methods Appraisal Tool (MMAT). Two independent researchers will extract data on factors promoting or reducing maternal health in indigenous communities, including the role or influence of traditional midwives. Fuzzy cognitive mapping will summarise the findings as a list of relationships between identified factors and outcomes with weights indicating strength of the relationship and the evidence supporting this.Ethics and disseminationThis review is part of a proposal approved by the ethics committees at McGill University and the Centro de Investigación de Enfermedades Tropicales in Guerrero. Participating indigenous communities in Guerrero State approved the study in 2015. The results of the scoping review will contribute to the field of cultural safety and intercultural dialogue for the promotion of maternal health in indigenous communities.
Health risk behaviours among migrants by duration of residence: protocol for a systematic review and meta-analysis
Authors: Berg Lisa , Gustafsson Nina-Katri , Honkaniemi Helena , Juárez Sol Pia 
Published: October 2020

IntroductionInternational migrants’ health has often been found to deteriorate in new countries, partly due to changes in health risk behaviours such as alcohol consumption, tobacco use, physical inactivity, and poor dietary habits. However, limited efforts have been made to comprehensively evaluate the extent to which migrants adopt unhealthy risk behaviours with longer duration of residence. This systematic review and meta-analysis will summarise evidence on international migrants’ behavioural patterns by duration of residence in multiple country contexts.Methods and analysisPubMed/MEDLINE, Web of Science and ProQuest databases will be searched for quantitative or mixed-method observational studies published in peer-reviewed scientific journals between 1 January 2000 and 31 December 2019. Studies comparing foreign-born individuals by duration of residence will be included. Information on study characteristics, descriptive statistics and measures of effect will be extracted. All included studies will be quality assessed using a modified Newcastle-Ottawa scale. The review will include narrative synthesis and, if sufficient and comparable data are available, random effects meta-analyses. The review will be conducted in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Ethics and disseminationEthical approval is not required since previously published information from peer-reviewed studies will be assessed. The results of this review will be published in peer-reviewed journals and presented at scientific conferences. Other forms of dissemination will include communication to broader audiences using well-established channels, including through university-based press releases. Progress will be regularly updated on the International Prospective Register of Systematic Reviews to ensure full transparency.PROSPERO registration numberCRD42018108881
Public managers’ role in creating workplace social capital (WSC) and its effect on employees’ well-being and health: a protocol of a longitudinal cohort study (PUMA-WSC)
Authors: Pihl-Thingvad Signe , Hansen Sune W , Winter Vera , Hansen Michelle S , Willems Jurgen 
Published: October 2020

IntroductionWorkplace social capital (WSC) has been shown to affect employees’ well-being and health, yet it is not clear how public managers can create WSC and which forms of WSC are most important. This study is the first prospective cohort study to examine the relationship between management behaviour, WSC, well-being and sickness absence. It uses a validated and detailed scale on WSC, which can distinguish between bonding, bridging, linking and organisational WSC over time. The study thereby provides rich data giving a much-needed detailed image of how WSC impacts on public employees’ well-being and health. Additionally, the study pays special attention to the fact that these relationships can be different for different types of employees and therefore tests a set of relevant employee and context-related variables.Methods and analysisProject preparations in terms of agreements and data preparation of existing data started in 2019. This prospective cohort study considers and collects organisational data from 2016 to 2025. Annual employee surveys of more than 8000 employees (in a large Danish municipality) will be combined with register data in all years. This generates a unique cohort of public employees in different professions that are traceable over several years. The annual surveys include information on the management behaviour, WSC and employee outcomes. Fine-grained information on sickness absences will be matched for all employees and years under study. Moreover, confounders and the nested nature of the data will be considered.Ethics and disseminationApproval has been obtained from The Regional Committee on Health Research Ethics from Southern Denmark and from the University of Southern Denmark. The results will be presented at conferences and published in international peer-reviewed journals and in a practice-oriented monography targeted at public managers. The result will furthermore be disseminated to the involved employees through seminars and workshops in the participating organisations.
Novel cytokine–antibody fusion protein, N-820, to enhance the functions of ex vivo expanded natural killer cells against Burkitt lymphoma
Authors: Chu Yaya , Nayyar Gaurav , Kham Su Nang , Rosenblum Jeremy M , Soon-Shiong Patrick , Lee John , Safrit Jeffrey T , Barth Matthew , Lee Dean , Cairo Mitchell S 
Published: October 2020

BackgroundThe prognosis of patients with relapsed or progressive B cell (CD20+) non-Hodgkin’s lymphoma (B-NHL), including Burkitt lymphoma (BL), is dismal due to chemoradiotherapy resistance. Novel therapeutic strategies are urgently needed. N-820 is a fusion protein of N-803 (formerly known as ALT-803) to four single-chains of rituximab. This agent has tri-specific binding activity to CD20 and enhanced antibody-dependent cell-mediated cytotoxicity.MethodsWe investigated the anti-tumor combinatorial effects of N-820 with ex vivo expanded peripheral blood natural killer (exPBNK) cells against rituximab-sensitive and rituximab-resistant CD20+ BL in vitro using cytoxicity assays and in vivo using human BL xenografted NOD/SCID/IL2rγnull (NSG) mice. We also investigated the cytokines/chemokines/growth factors released using ELISA and multiplex assay. Gene expression changes were examined using real-time PCR arrays.ResultsN-820 significantly enhanced the expression of NK activating receptors (p<0.001) and the proliferation of exPBNK cells with enhanced Ki67 expression and Stat5 phosphorylation (p<0.001). N-820 significantly enhanced the secretion of cytokines, chemokines, and growth factors including GM-CSF, RANTES, MIP-1B (p<0.001) from exPBNK cells as compared with the combination of rituximab+N-803. Importantly, N-820 significantly enhanced in vitro cytotoxicity (p<0.001) of exPBNK with enhanced granzyme B and IFN-γ release (p<0.001) against BL. Gene expression profiles in exPBNK stimulated by N-820+Raji-2R showed enhanced transcription of CXCL9, CXCL1, CSF2, CSF3, GZMB, and IFNG. Moreover, N-820 combined with exPBNK significantly inhibited rituximab-resistant BL growth (p<0.05) and extended the survival (p<0.05) of BL xenografted NSG mice.ConclusionsOur results provide the rationale for the development of a clinical trial of N-820 alone or in combination with endogenous or ex vivo expanded NK cells in patients with CD20+ B-NHL failing prior rituximab containing chemoimmunotherapy regimens.
Impact of 2 different aerobic periodization training protocols on left ventricular function in patients with stable coronary artery disease: an exploratory study
Authors: Boidin Maxime , David Louis-Philippe , Trachsel Lukas D. , Gayda Mathieu , Tremblay Jonathan , Lalongé Julie , Juneau Martin , Nigam Anil , Henri Christine 
Published: October 2020

We compared the impacts of linear (LP) and nonlinear (NLP) aerobic training periodizations on left ventricular (LV) function and geometry in coronary artery disease (CAD) patients. Thirty-nine CAD patients were randomized to either a 3-month isoenergetic supervised LP or NLP. All underwent standard echocardiography with assessment of 3D LV ejection fraction (LVEF), diastolic function, strain (global longitudinal, radial, and circumferential), and strain rate at baseline and study end. Training was performed 3 times/week and included high-intensity interval and moderate-intensity continuous training sessions. Training load was progressively increased in the LP group, while it was deeply increased and intercepted with a recovery week each fourth week in the NLP group. For the 34 analyzed patients, we found similar improvements for 3D LVEF (effect size (ES): LP, 0.29; NLP, 0.77), radial strain (ES: LP, 0.58; NLP, 0.48), and radial strain rate (ES: LP, 0.87; NLP, 0.17) in both groups (time for all: p ≤ 0.01). All other parameters of cardiac function remained similar. In conclusion, NLP and LP led to similar improvements in 3D LVEF and radial strain, suggesting a favourable positive cardiac remodelling through myofibers reorganization. These findings must be investigated in patients with more severe cardiac dysfunction. The study was registered on ClinicalTrials.gov (NCT03443193). Novelty: Linear and nonlinear periodization programs improved radial strain, accompanied by improvement of ejection fraction. Both aerobic periodization programs did not negatively impact cardiac function in coronary artery disease patients.
Effect of high-fat diet on mechanosensitive transient receptor potential channel activation in vagal afferent neurons
Authors: Park Sung Jin , Yu Yang , Beyak Michael J. 
Published: October 2020

Mechanical stimulation of the gastrointestinal tract is an important stimulus of satiety and can be transduced by transient receptor potential (TRP) channels. Several studies have revealed attenuated vagally-mediated satiety responses including mechanosensitivity in diet-induced obesity; however, ion channels underlying this hyposensitivity have not been fully understood. This study aimed to examine the effect of chronic high-fat diet on activation of selected mechanosensitive TRP channels in vagal afferents. C57/BL6 mice were fed on either a high-fat or low-fat diet for 6–8 weeks. An increase in the intracellular calcium to hypotonic solution and activators of TRPV1, TRPV4, and TRPA1 was measured in nodose neurons using Ca2+-imaging techniques. Jejunal afferent nerve firing induced by mechanical stimulation and TRP channel agonists was measured using in vitro extracellular multiunit afferent recording. In high-fat diet–fed mice, we observed reduced calcium influx and jejunal afferent response induced by mechanical stimuli and agonists of TRPV4 and TRPA1, but not TRPV1. Our data show diet-induced obesity disrupts the activation of TRPV4 and TRPA1, at both the cellular level and the level of nerve terminals in the small intestine, which may partly explain reduced mechanosensitivity of vagal afferents and may contribute to decreased gut-brain satiety signaling in obesity.
Protective effect of sitagliptin and whole-body γ-irradiation in diabetes-induced cardiac injury
Authors: Mansour Suzan M. , Aly Sara , Hassan Seham H.M. , Zaki Hala F. 
Published: October 2020

Diabetes mellitus is associated with an increased risk of cardiac complications; this study aimed to investigate effect of sitagliptin (SITA) alone or combined with γ-irradiation on diabetes-associated cardiac injury. Rats were treated with SITA (100 mg/kg per day; p.o.) for 2 weeks followed by a single dose of whole-body γ-irradiation (3 Gy). Solitary administration of SITA or combined treatment with γ-irradiation succeeded to ameliorate the increase in serum levels of glucose, total cholesterol, triglycerides, creatine kinase-MB, and malondialdehyde, coupled by increased insulin and reduced glutathione levels. Their cardioprotective potential was confirmed through attenuating the apoptotic signaling by mitigating Bcl-2-associated X protein, caspase-3, and apoptosis-inducing factor expression, while augmenting the anti-apoptotic factors, B cell lymphoma-2 (Bcl-2), and heat shock protein 70 (HSP-70) in left ventricular tissue homogenates. These findings were supported histopathologically. In conclusion, treatment with SITA alone or combined with γ-irradiation may prove beneficial in diabetes-accompanied cardiac insult. This could be due to the crosstalk between the antioxidant, anti-apoptotic, and restoration of body’s defense capacities.