bluuebunny/crossref_metadata_2025_split huggingface dataset:
TSCH Networks for Health IoT
Authors: Elsts Atis , Fafoutis Xenofon , Oikonomou George , Piechocki Robert , Craddock Ian 
Published: April 2020

The emerging Internet of Things has the potential to solve major societal challenges associated with healthcare provision. Low-power wireless protocols for residential Health Internet of Things applications are characterized by high reliability requirements, the need for energy-efficient operation, and the need to operate robustly in diverse environments in the presence of external interference. We enhance and experimentally evaluate the Time-Slotted Channel Hopping protocol from the IEEE 802.15.4 standard to address these challenges. Our contributions are a new schedule and an adaptive channel selection mechanism to increase the performance of time-slotted channel hopping in this domain. Evaluation in a test house shows that the enhanced system is suitable for our e-Health application and compares favorably with state-of-the-art options. The schedule provides higher reliability compared with the minimal scheduling function from the IETF 6TiSCH Working Group and has a better energy-efficiency/reliability tradeoff than the Orchestra scheduler. Results from 29 long-term residential deployments confirm the suitability for the application and show that the system is able to adapt and avoid channels used by WiFi. In these uncontrolled environments, the system achieves 99.96% average reliability for networks that generate 7.5 packets per second on average.
H2A Monoubiquitination Links Glucose Availability to Epigenetic Regulation of the Endoplasmic Reticulum Stress Response and Cancer Cell Death
Authors: Zhang Yilei , Shi Jiejun , Liu Xiaoguang , Xiao Zhenna , Lei Guang , Lee Hyemin , Koppula Pranavi , Cheng Weijie , Mao Chao , Zhuang Li , Ma Li , Li Wei , Gan Boyi 
Published: April 2020

Abstract

Epigenetic regulation of gene transcription has been shown to coordinate with nutrient availability, yet the mechanisms underlying this coordination remain incompletely understood. Here, we show that glucose starvation suppresses histone 2A K119 monoubiquitination (H2Aub), a histone modification that correlates with gene repression. Glucose starvation suppressed H2Aub levels independently of energy stress–mediated AMP-activated protein kinase activation and possibly through NADPH depletion and subsequent inhibition of BMI1, an integral component of polycomb-repressive complex 1 (PRC1) that catalyzes H2Aub on chromatin. Integrated transcriptomic and epigenomic analyses linked glucose starvation–mediated H2Aub repression to the activation of genes involved in the endoplasmic reticulum (ER) stress response. We further showed that this epigenetic mechanism has a role in glucose starvation–induced cell death and that pharmacologic inhibition of glucose transporter 1 and PRC1 synergistically promoted ER stress and suppressed tumor growth in vivo. Together, these results reveal a hitherto unrecognized epigenetic mechanism coupling glucose availability to the ER stress response.

Significance:
These findings link glucose deprivation and H2A ubiquitination to regulation of the ER stress response in tumor growth and demonstrate pharmacologic susceptibility to inhibition of polycomb and glucose transporters.
Global Reach 2018 Heightened α-Adrenergic Signaling Impairs Endothelial Function During Chronic Exposure to Hypobaric Hypoxia
Authors: Tymko Michael M. , Lawley Justin S. , Ainslie Philip N. , Hansen Alexander B. , Hofstaetter Florian , Rainer Simon , Amin Sachin , Moralez Gilbert , Gasho Christopher , Vizcardo-Galindo Gustavo , Bermudez Daniela , Villafuerte Francisco C. , Hearon Christopher M. 
Published: April 2020

Rationale:
Chronic exposure to hypoxia is associated with elevated sympathetic nervous activity and reduced vascular function in lowlanders, and Andean highlanders suffering from excessive erythrocytosis (EE); however, the mechanistic link between chronically elevated sympathetic nervous activity and hypoxia-induced vascular dysfunction has not been determined.

Objective:
To determine the impact of heightened sympathetic nervous activity on resistance artery endothelial-dependent dilation (EDD), and endothelial-independent dilation, in lowlanders and Andean highlanders with and without EE.

Methods and Results:

We tested healthy lowlanders (n=9) at sea level (344 m) and following 14 to 21 days at high altitude (4300 m), and permanent Andean highlanders with (n=6) and without (n=9) EE at high altitude. Vascular function was assessed using intraarterial infusions (3 progressive doses) of acetylcholine (ACh; EDD) and sodium nitroprusside (endothelial-independent dilation) before and after local α+β adrenergic receptor blockade (phentolamine and propranolol). Intraarterial blood pressure, heart rate, and simultaneous brachial artery diameter and blood velocity were recorded at rest and during drug infusion. Changes in forearm vascular conductance were calculated. The main findings were (1) chronic hypoxia reduced EDD in lowlanders (changes in forearm vascular conductance from sea level: ACh1: −52.7±19.6%, ACh2: −25.4±38.7%, ACh3: −35.1±34.7%, all
P
≤0.02); and in Andeans with EE compared with non-EE (changes in forearm vascular conductance at ACh3: −36.4%,
P
=0.007). Adrenergic blockade fully restored EDD in lowlanders at high altitude, and normalized EDD between EE and non-EE Andeans. (2) Chronic hypoxia had no effect on endothelial-independent dilation in lowlanders, and no differences were detected between EE and non-EE Andeans; however, EID was increased in the non-EE Andeans after adrenergic blockade (
P
=0.012), but this effect was not observed in the EE Andeans.

Conclusions:
These data indicate that chronic hypoxia reduces EDD via heightened α-adrenergic signaling in lowlanders and in Andeans with EE. These vascular mechanisms have important implications for understanding the physiological consequences of acute and chronic high altitude adaptation.
Predicted Versus Observed Major Adverse Cardiac Event Risk in Women With Evidence of Ischemia and No Obstructive Coronary Artery Disease: A Report From WISE (Women's Ischemia Syndrome Evaluation)
Authors: Sedlak Tara , Herscovici Romana , Cook‐Wiens Galen , Handberg Eileen , Wei Janet , Shufelt Chrisandra , Bittner Vera , Reis Steven E. , Reichek Nathaniel , Pepine Carl , Bairey Merz C. Noel 
Published: April 2020

Background

Primary prevention risk scores are commonly used to predict cardiovascular (
CVD
) outcomes. The applicability of these scores in patients with evidence of myocardial ischemia but no obstructive coronary artery disease is unclear.

Methods and Results

Among 935 women with signs and symptoms of ischemia enrolled in
WISE
(Women's Ischemia Syndrome Evaluation), 567 had no obstructive coronary artery disease on angiography. Of these, 433 had had available risk data for 6 commonly used scores: Framingham Risk Score, Reynolds Risk Score, Adult Treatment Panel
III
, Atherosclerotic Cardiovascular Disease, Systematic Coronary Risk Evaluation, Cardiovascular Risk Score 2. Score‐specific
CVD
rates were assessed. For each score, we evaluated predicted versus observed event rates at 10‐year follow‐up using c statistic. Recalibration was done for 3 of the 6 scores. The 433 women had a mean age of 56.9±9.4 years, 82.5% were white, 52.7% had hypertension, 43.6% had dyslipidemia, and 16.9% had diabetes mellitus. The observed 10‐year score‐specific
CVD
rates varied between 5.54% (Systematic Coronary Risk Evaluation) to 28.87% (Framingham Risk Score), whereas predicted event rates varied from 1.86% (Systematic Coronary Risk Evaluation) to 6.99% (Cardiovascular Risk Score 2). The majority of scores showed moderate discrimination (c statistic 0.53 for Atherosclerotic Cardiovascular Disease and Systematic Coronary Risk Evaluation; 0.78 for Framingham Risk Score) and underestimated risk (statistical discordance −58% for Adult Treatment Panel
III
; −84% for Atherosclerotic Cardiovascular Disease). Recalibrated Reynolds Risk Score, Atherosclerotic Cardiovascular Disease, and Framingham Risk Score had improved performance, but significant underestimation remained.

Conclusions

Commonly used
CVD
risk scores fail to accurately predict
CVD
rates in women with ischemia and no obstructive coronary artery disease. These results emphasize the need for new risk assessment scores to reliably assess this population.
The Philosophy of Taha Abderrahman: A Critical Study
Authors: Suleiman Farid 
Published: April 2020

Abstract
This paper provides a critical reading of some of the most important elements in the philosophy of the Moroccan thinker Taha Abderrahman (TA) (b. 1944), who has had a significant impact on contemporary Arab thought. It examines (1) his views on the essence of being human and the degrees of reason, (2) his concept of iʾtimāniyya (trusteeship paradigm), (3) his concept of the ‘discursive field’ (al-majāl al-tadāwulī) and how it relates to his struggle for intellectual emancipation from the hegemony of the West, and (4) his views on politics and democracy. First, the paper argues that TA is not as innovative as he repeatedly claims to be in his works; rather, he promotes a traditional type of Sufism that he skilfully cloaks in modern language, as well as in numerous neologisms that he himself has invented. Second, it is shown that any reading of TA’s philosophy must take into account his affiliation with the Budshishiyya Sufi order (one of the most influential players in the internal power structure of the Moroccan state). This paper contributes to the study of philosophy in the modern Arab world in general and to the study of TA in particular, who thus far has received only limited attention in Western academia.
Negotiations on Arms Control: Is There a Future?
Authors: Hopmann P. Terrence 
Published: April 2020

Abstract
The global arms control regime that began with the Partial Nuclear Test Ban Treaty (1963) appears to be collapsing rapidly, with many agreements now abandoned or barely enforced. This article analyzes some of the challenges to new negotiations on arms control based on developments in negotiation theory over the past 60 years. It focuses on the management of multilateral rather than bilateral negotiations, the need to focus on absolute rather than relative gains, the use of problem-solving techniques rather than traditional bargaining, the management of domestic opposition to arms control, the need for national leaders to become active proponents of new negotiations, and the need to focus on norms of cooperative security rather than engaging in arms races. It concludes that a necessary, if not sufficient, condition to save and rebuild the arms control regime is the adoption of more constructive approaches to negotiation on these vital issues.
Merging Yoga and Occupational Therapy for Parkinson’s Disease improves fatigue management and activity and participation measures
Authors: Hill Heather M , Swink Laura A , Atler Karen E , Anderson Abby K , Fling Brett W , Schmid Arlene A 
Published: April 2020

Introduction The purpose of this study was to explore the influence of a falls-risk management intervention, Merging Yoga and Occupational Therapy for Parkinson’s Disease, on fatigue and activity and participation measures, as well as examine the relationship between these constructs. Methods This mixed methods study included 17 participants with Parkinson’s disease. Participants took the Modified Fatigue Impact Scale and the International Classification of Functioning, Disability, and Health Measure of Participation and Activities Screener at three 8-week intervals: baseline (followed by an 8-week control period), pre-intervention, and post-intervention. Focus groups were completed at the conclusion of the study to explore participants’ perception of Merging Yoga and Occupational Therapy for Parkinson’s Disease related to their fatigue and activity and participation. Results Fatigue and activity and participation measures were significantly correlated ( r = 0.76). Activity and participation measures (Measure of Participation and Activities Screener) significantly improved after the intervention ( p = 0.012). Four themes related to fatigue and/or activity and participation emerged following qualitative analysis, including: managing fatigue: paying attention and acting accordingly; creating mindfulness in daily activities; giving and receiving within a community; and strengthening relationship to self and others. Conclusion Participants experienced improvement in activity and participation measures and perceived fatigue management after engagement in the community-based Merging Yoga and Occupational Therapy for Parkinson’s Disease program.
The Connect CLL Registry: final analysis of 1494 patients with chronic lymphocytic leukemia across 199 US sites
Authors: Mato Anthony , Nabhan Chadi , Lamanna Nicole , Kay Neil E. , Grinblatt David L. , Flowers Christopher R. , Farber Charles M. , Davids Matthew S. , Swern Arlene S. , Sullivan Kristen , Flick E. Dawn , Gressett Ussery Sarah M. , Gharibo Mecide , Kiselev Pavel , Sharman Jeff P. 
Published: April 2020

Abstract
Optimal treatment of chronic lymphocytic leukemia (CLL) remains unclear. The Connect CLL Registry, a United States–based multicenter prospective observational cohort study, enrolled 1494 patients between 2010 and 2014 from predominantly community-based settings. Patients were grouped by line of therapy (LOT) at enrollment. With a median follow-up of 46.6 months (range, 0-63.0 months), median overall survival (OS) was not reached in LOT1, 63.0 months (95% confidence interval [CI], 46.0-63.0 months) in LOT2, and 38.0 months (95% CI, 33.0-47.0 months) in LOT≥3. Bendamustine and rituximab (BR; 33.5%); fludarabine, cyclophosphamide, and rituximab (FCR; 21.4%); and rituximab monotherapy (18.5%) were the most common regimens across LOTs. Median event-free survival (EFS) was similar in patients treated with BR (59.0 months) and FCR (55.0 months) in LOT1; median OS was not reached. In multivariable analysis, BR or FCR vs other treatments in LOT1 was associated with improved EFS (hazard ratio [HR], 0.60; P &lt; .0001) and OS (0.67; P = .0162). Using the Kaplan-Meier product limit, ibrutinib vs other treatments improved OS in LOT2 (HR, 0.279; P = .009), LOT3 (0.441; P = .011), and LOT≥4 (0.578; P = .043). Prognostic modeling of death at 2 years postenrollment identified 3 risk groups: low (mortality rate, 6.2%), medium (14.5%), and high (27.4%). The most frequent adverse events across LOTs were pneumonia (11.6%) and febrile neutropenia (6.2%). These data suggest that advantages of LOT1 FCR over BR seen in clinical trials may not translate to community practice, whereas receiving novel LOT2 agents improved outcomes. This trial was registered at www.clinicaltrials.gov as NCT01081015.
Grading and management of cytokine release syndrome in patients treated with tisagenlecleucel in the JULIET trial
Authors: Schuster Stephen J. , Maziarz Richard T. , Rusch Elisha S. , Li Junlong , Signorovitch James E. , Romanov Vadim V. , Locke Frederick L. , Maloney David G. 
Published: April 2020

Abstract
Chimeric antigen receptor T-cell (CAR-T) therapy yields durable responses in patients with relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL). Cytokine release syndrome (CRS) is a CAR-T therapy–related adverse event. To date, clinical trials of different CAR-T products have not been aligned on CRS grading scales and management algorithms. We assessed concordance between the Penn, Lee, and American Society for Transplantation and Cellular Therapy (ASTCT) grading systems by retrospectively regrading CRS events in the JULIET (A Phase 2, Single Arm, Multicenter Trial to Determine the Efficacy and Safety of CTL019 in Adult Patients With Relapsed or Refractory DLBCL) trial. Four medical experts with experience treating patients with 3 different CAR-T products independently regraded individual patient-level CRS events from the phase 2, global, pivotal JULIET trial (#NCT02445248). As of 8 December 2017, a total of 111 patients with r/r DLBCL underwent infusion with tisagenlecleucel. Sixty-four patients had CRS events graded per the Penn scale; on retrospective review, 63 and 61 patients had CRS events regraded per the Lee and ASTCT criteria, respectively. The Lee scale yielded concordance for 39, lower grade for 20, and higher grade for 5 events compared with the Penn scale. The ASTCT criteria provided concordance for 37, lower grade for 23, and higher grade for 4 events compared with the Penn scale. Sixteen (14%) of 111 patients in the JULIET trial received tocilizumab, all for severe events (Penn grade 3/4 CRS). This study is the first to assess concordance between 3 CRS grading scales using the same patient data set and to compare tocilizumab use according to the Lee scale in the JULIET trial and the ZUMA-1 (Long-Term Safety and Activity of Axicabtagene Ciloleucel in Refractory Large B-Cell Lymphoma) trial. This analysis describes key differences between grading scales and may inform CRS management practices.
Analysis of Power Matching on Energy Savings of a Pneumatic Rotary Actuator Servo-Control System
Authors: Zhang Yeming , Yue Hongwei , Li Ke , Cai Maolin 
Published: April 2020

AbstractWhen saving energy in a pneumatic system, the problem of energy losses is usually solved by reducing the air supply pressure. The power-matching method is applied to optimize the air-supply pressure of the pneumatic system, and the energy-saving effect is verified by experiments. First, the experimental platform of a pneumatic rotary actuator servo-control system is built, and the mechanism of the valve-controlled cylinder system is analyzed. Then, the output power characteristics and load characteristics of the system are derived, and their characteristic curves are drawn. The employed air compressor is considered as a constant-pressure source of a quantitative pump, and the power characteristic of the system is matched. The power source characteristic curve should envelope the output characteristic curve and load characteristic curve. The minimum gas supply pressure obtained by power matching represents the optimal gas supply pressure. The comparative experiments under two different gas supply pressure conditions show that the system under the optimal gas supply pressure can greatly reduce energy losses.
Tryptophan-like fluorescence as a fingerprint of dry-weather misconnections into storm drainage system
Authors: Yin Hailong , Wang Yue , Yang Yang , Huang Jingshui , Xu Zuxin 
Published: April 2020

Abstract
Background
Inappropriate dry-weather misconnections into storm drainage system are a demanding environmental problem worldwide, which leads to unexpected dry-weather discharge into surface waters. It often costs a large amount of manpower and resources to identify the source of misconnections and estimate its contributions. In this study, we evaluated the possibility of quantifying proportional source contribution in a storm drainage system with dry-weather misconnections from domestic sewage and river water inflow, using rapid and low-cost fluorescence spectroscopy methods. For this purpose, samples of both misconnection sources and outflows of storm drainage system were collected and analyzed in a downtown catchment of Shanghai, China.

Results
Results showed that fluorescent peak intensity of tryptophan-like T1 in domestic sewage (802 ± 126 a.u.) was significantly higher than that in urban river water (57 ± 12 a.u.), while fluorescent peak intensities of tryptophan-like T2 in urban river water (732 ± 304 a.u.) was much higher than that in domestic sewage (261 ± 64 a.u.) due to increased algal activity in the local river and upstream inflow chemistry. However, only peak T2 passed the conservative behavior test in the incubation experiments, which could be used as a fingerprint for quantitatively identifying the misconnections. We further developed a Bayesian fluorescence mass balance model (FMBM) to infer the percentage of dry-weather misconnections into the storm drainage system as a function of fluorescence intensities of peak T2 in the samples of sources and outflow. It was found that the maximum posteriori probability estimate of the percentage of river water intrusion into the storm drains was up to 20.8% in this site, which was validated by the results of on-site investigation.

Conclusion
Our findings implied that in situ fluorescent sensors and Bayesian FMBM for the fingerprint fluorescence peak could be applied to fast track inappropriate dry-weather misconnections into storm drainage system qualitatively and quantitatively with low costs.
RIPK1 polymorphisms alter the susceptibility to cervical Cancer among the Uyghur population in China
Authors: Tuoheti Zulipiyamu , Han Lili , Husaiyin Sulaiya , Liu Xiaoxi , Ma Chunhua , Niyazi Mayinuer 
Published: April 2020

Abstract
Background
RIPK1 (receptor-interacting protein kinase-1) plays a role in cancer development, whereas no clear studies focused on the cervical cancer. The objective of this study was to evaluate the relationship between RIPK1 polymorphisms and cervical cancer risk among the Uyghur population.

Methods
We performed a case-control study including 342 cervical cancer patients and 498 age-matched healthy controls. Four RIPK1 genetic variants (rs6907943, rs2077681, rs9503400 and rs17548629) were genotyped with Agena MassARRAY platform. The associations between RIPK1 polymorphisms and cervical cancer risk were assessed under Binary logistic regression models. False discovery rate (FDR) was used to improve the results reliability.

Results
The results showed rs2077681 was significantly associated with cervical cancer risk under various genetic models (codominant: OR = 3.14, 95% CI = 1.40–7.07, p = 0.006, FDR-p = 0.018; recessive: OR = 3.20, 95% CI = 1.43–7.16, p = 0.005, FDR-0.018). The stratified analysis indicated that the relationships of rs6907946, rs9503400 and rs17548629 with cervical cancer risk were statistically significant in the subgroup of clinical stage (p < 0.05).

Conclusion
Our findings demonstrated that RIPK1 polymorphisms were associated with cervical cancer susceptibility among the Uyghur population in China, and RIPK1 polymorphisms might be involved in the development of cervical cancer.
Anxiety levels among health sciences students during their first visit to the dissection room
Authors: Romo-Barrientos Carmen , Criado-Álvarez Juan José , González-González Jaime , Ubeda-Bañon Isabel , Flores-Cuadrado Alicia , Saiz-Sánchez Daniel , Viñuela Antonio , Martin-Conty Jose Luis , Simón Teresa , Martinez-Marcos Alino , Mohedano-Moriano Alicia 
Published: April 2020

AbstractBackgroundThe teaching of human anatomy is often based on practices of cadaver dissection and prosected specimens. However, exposure to human cadavers might be stressful and anxiety-inducing for students. The aim of this study is to explore the degree of satisfaction and anxiety among first-year students in the Medicine, Occupational Therapy, Speech Therapy and Nursing programmes at the Universidad de Castilla-La Mancha (Spain) who are experiencing their first dissection/prosection practice to develop stress coping strategies.MethodsA total of 204 health sciences students participated in this study. The State-Trait Anxiety Inventory was used to evaluate anxiety.Results‘State Anxiety’ (SA) decreased significantly throughout the course (p < 0.05), from 20.7 ± 19.29 to 13.7 ± 11.65 points. Statistical differences (p < 0.05) in SA were found between the different health sciences, and pre-practice SA was significantly different from post-practice SA. The students with the highest pre-practice SA levels were nursing students (31.8 ± 33.7 points), but medical students had the highest post-practice SA levels (18.4 ± 12.82 points).ConclusionsAlthough students were satisfied with dissection practices (96.8% of them recommended that the practices be retained for future courses), the experience can provoke stressful responses that must be addressed using advanced preparation and coping mechanisms, especially among medical and nursing students.