bluuebunny/crossref_metadata_2025_split huggingface dataset:
Traumatic Fractures of the Thoracic Spine
Authors: Spiegl Ulrich J. A. , Schnake Klaus John , Hartmann Frank , Katscher Sebastian , Riehle Marion , Scheyerer Max J. , Schmeiser Gregor , Siekmann Holger , Osterhoff Georg 
Published: May 2020

AbstractThe majority of traumatic vertebral fractures occur at the thoracolumbar junction and the lumbar spine and less commonly at the mid-thoracic and upper thoracic spine. In accordance, a high number of articles are dealing with thoracolumbar fractures focusing on the thoracolumbar junction. Nonetheless, the biomechanics of the thoracic spine differ from the thoracolumbar junction and the lumbar vertebral spine. The aim of this review is to screen the literature dealing with acute traumatic thoracic vertebral fractures in patients with normal bone quality. Thereby, the diagnostic of thoracic vertebral body fractures should include a CT examination. Ideally, the CT should include the whole thoracic cage particularly in patients suffering high energy accidents or in those with clinical suspicion of concomitant thoracic injuries. Generally, concomitant thoracic injuries are frequently seen in patients with thoracic spine fractures. Particularly sternal fractures cause an
increase in fracture instability. In case of doubt, long segment stabilization is recommended in patients with unstable mid- und upper thoracic fractures, particularly in those patients with a high grade of instability.
Morphological and Molecular Assessment in Thyroid Cytology Using Cell-Capturing Scaffolds
Authors: Scarpino Stefania , Taccogna Silvia , Pepe Giuseppina , Papini Enrico , D’Angelo Martina , Cascone Federica , Nicoletti Daniele , Guglielmi Rinaldo , Palermo Andrea , Trombetta Marcella , Rainer Alberto , Taffon Chiara , Crescenzi Anna 
Published: May 2020

AbstractThe increased frequency of thyroid nodules is paralleled by the rise of thyroid cancer diagnosis. To define the nature of most thyroid nodules, fine needle aspiration (FNA) followed by cytological evaluation is considered the method of choice. About 20% of FNA biopsies on thyroid nodules, however, show indeterminate cytological features and may require diagnostic surgery. Several immunocytochemical and molecular markers have been proposed to improve classification of thyroid nodules, but these tests require adequate cell amount and cytological paraffin inclusion. Polymeric matrices were recently proposed for the collection of cells for diagnostic purposes. In this study, we evaluated the diagnostic use of a new matrix (CytoMatrix). Morphological, molecular and immunohistochemical investigations were carried out on 23 FNA samples included in CytoMatrix and compared with data obtained from the definitive histology of surgical samples. Our results showed that CytoMatrix is suitable to capture and preserve the cellularity of the samples harvested by FNA and that its paraffin sections mimic the morphology of those obtained from real histological tissue. Immunohistochemistry on CytoMatrix samples was consistent with the immunophenotypical profile of the corresponding histological surgical specimens. Mutational analysis of the BRAF (V600E) gene performed on CytoMatrix inclusions and paired surgical tissue matched in all but one cases while matrix immunohistochemistry identified 91.6% of BRAF mutated samples. In conclusion, we suggest that CytoMatrix could be a reliable tool to overcome the current limits of traditional collection methods for the study of thyroid cytology, thereby improving their reliability for a conclusive diagnostic interpretation.
Venous Tumor Thrombosis and Pulmonary Metastases in a Case of Adrenal Neuroblastoma—Occurrence of Two Rare Manifestations in a Single Patient: Case Report and Review of Literature
Authors: Singh Somesh , Kembhavi Seema , Shah Sneha , Vora Tushar , Chinnaswamy Girish , Qureshi Sajid 
Published: May 2020

AbstractUnlike other pediatric extra cranial solid neoplasms, neuroblastomas have very low incidence of pulmonary metastases. Neuroblastomas also tend to encase rather than infiltrate the major vessels with very low incidence of tumor thrombus. Even in cases with inferior vena cava tumor thrombosis, pulmonary metastases are a rare occurrence. These patients usually show widespread disseminated disease at presentation. We present a rare case of adrenal neuroblastoma with tumor thrombus and bilateral pulmonary metastases at presentation. This presentation can be confused with adrenocortical carcinoma and differentiating between the two is essential for further management.
Female Sex as a Risk Modifier for Stroke Risk in Atrial Fibrillation: Using CHA2DS2-VASc versus CHA2DS2-VA for Stroke Risk Stratification in Atrial Fibrillation: A Note of Caution
Authors: Nielsen Peter Brønnum , Overvad Thure Filskov 
Published: May 2020

AbstractStroke prevention is a key clinical concern in the management of patients with atrial fibrillation. Oral anticoagulation treatment reduces the risk of disabling stroke, but the treatment increases the risk of bleeding. For decades, the decision to initiate oral anticoagulation has been guided by clinical risk scoring systems such as the CHADS2 and CHA2DS2-VASc scores. In this narrative review, we focus on the recent discussion of the “Sc” (Sex Category) criterion in the CHA2DS2-VASc score. Epidemiological considerations when assessing stroke rates in cohorts are discussed, and the implications of different methodological approaches are outlined. Next, we review studies investigating the association of the “Sc” criterion on the stroke rates under various approaches. Lastly, we discuss potential consequences of implementing the recently suggested sex-less CHA2DS2-VA score, which leaves out female sex from stroke risk assessment in atrial fibrillation.
Pharmacology, Efficacy and Safety of a Triple-Secured Fibrinogen Concentrate in Children Less than or Equal to 12 Years with Afibrinogenaemia
Authors: Djambas Khayat Claudia , El Khorassani Mohamed , Aytaç Selin , Harroche Annie , Dahmane Amel , Pujol Sonia , Henriet Céline , de Moerloose Philippe , Bridey Françoise 
Published: May 2020

Abstract
Objective To date, the use of a fibrinogen concentrate (FC) administered in children with inherited fibrinogen deficiency is poorly documented. Treatment modalities may differ from those of adults. The aim of this study was to investigate the pharmacokinetics (PK), efficacy (bleeding/surgery) and safety of a triple-secured FC (FibCLOT, LFB, France) in young patients aged of 12 years or less.
Methods This was a prospective, non-comparative, multicentre, phase 2–3 study. Estimated PK parameters were based on population PK modelling. Target fibrinogen levels were 1.2 and 1.0 g/L for major and minor events, respectively. In vivo recovery (IVR) was calculated at study entry to tailor the dose.
Results Sixteen afibrinogenaemia patients were treated with FC: 12 included in the PK study (6 aged ≤ 6 years and 6 aged 7–12 years). IVR at 1 hour post-infusion (geometric mean [coefficient of variation]) was 1.91 [20%] mg/dL per mg/kg and results were similar between the two age groups (1.87 [14%]) and (1.96 [27%]) with no statistical differences. Estimated half-life (t
1/2) was 49.0 hours [12%] with no observed differences between groups (46.6 hours [10%] and 51.6 hours [12%]). Overall efficacy was rated as excellent/good in 96.9% of 32 bleeds and in 100% of 11 surgeries. Most of the events (39/43, 90.7%) were managed with one infusion. There was no serious adverse drug reaction.
Conclusion Individually tailored dosing was efficacious in children who exhibited a lower IVR and shorter t
1/2 than those previously reported in adolescent and adult patients emphasising the importance of individualised dose optimisation.
Risk Factors for Lower Extremity Amputation Following Attempted Free Flap Limb Salvage
Authors: Piwnica-Worms William , Stranix John T. , Othman Sammy , Kozak Geoffrey M. , Moyer Ilaina , Spencer Amy , Azoury Saïd C. , Levin L. Scott , Kovach Stephen J. 
Published: May 2020

Abstract
Background Traumatic limb salvage with free flap reconstruction versus primary amputation for lower extremity (LE) injuries remains an oft debated topic. Limb salvage has well-studied benefits and advances in microsurgery have helped reduce the complication rates. A subset of patients eventually requires secondary amputation after a failed attempt at limb salvage. A better understanding of risk factors that predict subsequent amputation after failed free flap reconstruction of LE injuries may improve operative management.
Patients and Methods A retrospective study (2002–2019) was conducted on all patients who underwent free flap reconstruction of the LE within 120 days of the original inciting event at a single institution. Patient and operative factors were reviewed including comorbidities, severity of the injury, flap choice, outcomes, and complications. Predictors of subsequent amputation were analyzed.
Results A total of 129 patients requiring free flap reconstructions for LE limb salvage met inclusion criteria. Anterolateral thigh flaps (70.5%) were performed most frequently. Secondary amputation occurred in 10 (7.8%) patients. Preoperative factors associated with eventual amputation include diabetes mellitus (p = 0.044), number of preoperative debridements (p = 0.013), evidence of any arterial injury/pathology (p = 0.008), specifically posterior tibial artery (p = < 0.0001), and degree of three-vessel runoff (p = 0.007). Operative factors associated with subsequent amputation include evidence of recipient artery injury/pathology (p = 0.008). Postoperative factors associated with secondary amputation include total flap failure (p = 0.001), partial flap failure (p = 0.002), minor complications (p = 0.037), and residual osteomyelitis (p = 0.028).
Conclusion Many factors contribute to the reconstructive surgical team's decision to proceed with limb salvage or perform primary amputation. Several variables are associated with failed limb salvage resulting in secondary amputation. Further studies are required to better guide management during the limb salvage process.
Whole-Exome Sequencing in NF1-Related West Syndrome Leads to the Identification of KCNC2 as a Novel Candidate Gene for Epilepsy
Authors: Schwarz Niklas , Weber Yvonne , Muhle Hiltrud , Rademacher Annika , Seiffert Simone , Pendziwiat Manuela , Rohr Axel , van Baalen Andreas , Helbig Ingo 
Published: May 2020

AbstractPatients with neurofibromatosis type 1 (NF1) have an increased risk for West syndrome (WS), but the underlying mechanisms linking NF1 and WS are unknown. In contrast to other neurocutaneous syndromes, intracerebral abnormalities explaining the course of infantile spasms (IS) are often absent and the seizure outcome is usually favorable. Several studies have investigated a potential genotype–phenotype correlation between NF1 and seizure susceptibility, but an association was not identified. Therefore, we identified three patients with NF1-related WS (NF1-WS) in a cohort of 51 NF1 patients and performed whole-exome sequencing (WES) to identify genetic modifiers. In two NF1 patients with WS and good seizure outcome, we did not identify variants in epilepsy-related genes. However, in a single patient with NF1-WS and transition to drug-resistant epilepsy, we identified a de novo variant in KCNC2 (c.G499T, p.D167Y) coding for Kv3.2 as a previously undescribed potassium channel to be correlated to epilepsy. Electrophysiological studies of the identified KCNC2 variant demonstrated both a strong loss-of-function effect for the current amplitude and a gain-of-function effect for the channel activation recommending a complex network effect. These results suggest that systematic genetic analysis for potentially secondary genetic etiologies in NF1 patients and severe epilepsy presentations should be done.
Do campaign posters trigger voting based on looks? Probing an explanation for why good-looking candidates win more votes
Authors: Herrmann Michael , Shikano Susumu 
Published: May 2020

AbstractNumerous studies document that better-looking candidates win more votes. Yet the causal mechanisms leading to this advantage remain unexplored. We consider for the first time a potential trigger of the looks–vote association that has previously been suggested but not tested in the literature: exposure to campaign posters of the candidates. We test this explanation with German election survey data, which we augment with ratings—provided by MTurk workers from the U.S.—of the attractiveness and facial competence of about 1,000 district candidates. Confirming previous studies on Germany, we find that attractiveness is positively associated with candidate vote share (1.2 ppts. min–max). At the voter level, we find tentative evidence for the idea that the association is moderated by exposure to campaign posters: effects are in the expected directions and their sizes consistent with what we observe at the candidate level, but we cannot always reject the null hypothesis of no effect. In contrast to attractiveness, we do not find conclusive evidence for an effect of facial competence in the election considered. These preliminary results suggest that inundating voters with candidate posters, as in elections in Germany and many other places, might be a reason for voting based on looks.
Inlaid microfluidic optics: absorbance cells in clear devices applied to nitrite and phosphate detection
Authors: Luy Edward A , Morgan Sean C , Creelman Joshua J , Murphy Benjamin J , Sieben Vincent J 
Published: May 2020

Abstract
A novel type of microfluidic absorbance cell is presented here that inlays black poly(methyl methacrylate) (PMMA) into a clear PMMA substrate to realize an isolated optical channel with microlitre volumes. Optical measurements are frequently performed on microfluidic devices, offering effective, quick, and robust chemical analysis capabilities on small amounts of sample. Many lab-on-chip systems utilize micrometer-sized channels to analyze liquid samples via light-absorbance measurements, but this requires sophisticated coordination of light through a small cross-section, often requiring collimating and beam-steering optics. Here, we detail the fabrication process to realize long path length absorbance cells based on a simple hybrid-material approach. A z-shape microchannel structure crosses a clear-black interface at both ends of the absorbance cell, thereby creating integral optical windows that permit light coupling into a microchannel completely embedded in black PMMA. Furthermore, we have integrated v-groove prisms on either side of the microfluidic channel. The prisms enabled seamless integration with printed circuit boards and permit the optical elements to be located off-chip without use of epoxies or adhesives. Three path lengths, 10.4, 25.4, and 50.4 mm, were created and used to characterize the novel cell design using typical colorimetric measurements for nitrite and phosphate. We compare the attenuation coefficient measured by our optical cells with the literature, showing excellent agreement across nutrient concentrations from 50 nM–50 μM. The measurements were performed with well-known reagent-based methods, namely the Griess assay for nitrite and the molybdovanadophosphoric acid or the ‘yellow method’ for phosphate. The longest 50.4 mm path length cell had a limit-of-detection of 6 nM for nitrite and 40 nM for phosphate, using less than 12 μl of fluid. The inlaid fabrication method described permits robust and high-performance optical measurements with broad applicability for in situ marine sensors and for numerous lab-on-chip sensors based on colorimetric assays. One such application is shown whereby two inlaid absorbance cells are integrated with four microfluidic check valves to realize a complete lab-on-chip nitrite sensor.
Metal-induced layer exchange of group IV materials
Authors: Toko Kaoru , Suemasu Takashi 
Published: May 2020

Abstract
Layer exchange (LE) is an interesting phenomenon in which metal and semiconductor layers exchange during heat treatment. A great deal of effort has been put into research on the mechanism and applications of LE, which has allowed various group IV materials (Si, SiGe, Ge, GeSn and C) to form on arbitrary substrates using appropriate metal catalysts. Depending on the LE material combination and growth conditions, the resulting semiconductor layer exhibits various features: low-temperature crystallization (80 °C–500 °C), grain size control (nm to mm orders), crystal orientation control to (100) or (111) and high impurity doping (>1020 cm−3). These features are useful for improving the performance, productivity and versatility of various devices, such as solar cells, transistors, thermoelectric generators and rechargeable batteries. We briefly review the findings and achievements from over 20 years of LE studies, including recent progress on device applications.
Ge(Sn) nano-island/Si heterostructure photodetectors with plasmonic antennas
Authors: Schlykow Viktoria , Manganelli Costanza Lucia , Römer Friedhard , Clausen Caterina , Augel Lion , Schulze Jörg , Katzer Jens , Schubert Michael Andreas , Witzigmann Bernd , Schroeder Thomas , Capellini Giovanni , Fischer Inga Anita 
Published: May 2020

Abstract
We report on photodetection in deep subwavelength Ge(Sn) nano-islands on Si nano-pillar substrates, in which self-aligned nano-antennas in the Al contact metal are used to enhance light absorption by means of local surface plasmon resonances. The impact of parameters such as substrate doping and device geometry on the measured responsivities are investigated and our experimental results are supported by simulations of the three-dimensional distribution of the electromagnetic fields. Comparatively high optical responsivities of about 0.1 A W−1 are observed as a consequence of the excitation of localized surface plasmons, making our nano-island photodetectors interesting for applications in which size reduction is essential.
Biocompatible superparamagnetic core-shell nanoparticles for potential use in hyperthermia-enabled drug release and as an enhanced contrast agent
Authors: Patil-Sen Yogita , Torino Enza , De Sarno Franca , Ponsiglione Alfonso Maria , Chhabria Vikesh , Ahmed Waqar , Mercer Tim 
Published: May 2020

Abstract
Superparamagnetic iron oxide nanoparticles (SPIONs) and core-shell type nanoparticles, consisting of SPIONs coated with mesoporous silica and/or lipid, were synthesised and tested for their potential theranostic applications in drug delivery, magnetic hyperthermia and as a contrast agent. Transmission Electron Microscopy (TEM) confirmed the size of bare and coated SPIONs was in the range of 5–20 nm and 100–200 nm respectively. The superparamagnetic nature of all the prepared nanomaterials as indicated by Vibrating Sample Magnetometry (VSM) and their heating properties under an AC field confirm their potential for hyperthermia applications. Scanning Column Magnetometry (SCM) data showed that extrusion of bare-SPION (b-SPION) dispersions through a 100 nm polycarbonate membrane significantly improved the dispersion stability of the sample. No sedimentation was apparent after 18 h compared to a pre-extrusion estimate of 43% settled at the bottom of the tube over the same time. Lipid coating also enhanced dispersion stability. Transversal relaxation time (T2) measurements for the nanoparticles, using a bench-top relaxometer, displayed a significantly lower value of 46 ms, with a narrow relaxation time distribution, for lipid silica coated SPIONs (Lip-SiSPIONs) as compared to that of 1316 ms for the b-SPIONs. Entrapment efficiency of the anticancer drug, Doxorubicin (DOX) for Lip-SPIONs was observed to be 35% which increased to 58% for Lip-SiSPIONs. Moreover, initial in-vitro cytotoxicity studies against human breast adenocarcinoma, MCF-7 cells showed that % cell viability increased from 57% for bSPIONs to 82% for Lip-SPIONs and to 87% for Lip-SiSPIONs. This suggests that silica and lipid coatings improve the biocompatibility of bSPIONs significantly and enhance the suitability of these particles as drug carriers. Hence, the magnetic nanomaterials prepared in this work have potential theranostic properties as a drug carrier for hyperthermia cancer therapy and also offer enhancement of contrast agent efficacy and a route to a significant increase in dispersion stability.
Parastatals and economic transformation in South Africa: The political economy of the Eskom crisis
Authors: Bowman Andrew 
Published: May 2020

ABSTRACT
This article analyses the causes, outcomes, and political significance of the inter-connected operational, financial, and governance crises afflicting Eskom, South Africa’s electricity parastatal. These crises emerged in the context of African National Congress initiatives to turn Eskom and other key parastatals into instruments of an envisaged South African developmental state, through increased investment and strategic procurement to support economic transformation goals. Instead, Eskom’s spiralling costs, procurement irregularities and inability to translate increased investment into functional new infrastructure meant it impeded these goals. Its indebtedness became a severe macro-economic risk, making Eskom a precarious nexus for the circulation of public funds, while the cost and unreliability of electricity has undermined South Africa’s energy-intensive industrial core. Intertwined with this were multiple high-profile corruption scandals associated with the ‘state-capture’ controversies of the latter stages of Jacob Zuma’s presidency. The article argues that Eskom’s extreme dysfunctionality results from long-running, and as yet unresolved, contestation of the parastatal and electricity policy more broadly by various interest groups, in a context of an increasingly fragmented political and business elite. This created a range of incoherent distributional pressures and institutional constraints. Rather than a straightforward outcome of corruption and ‘state capture’, this reflects deeper tensions in the post-apartheid political economy.
Remote monitoring contributes to preventing overwork-related events in health workers on the COVID-19 frontlines
Authors: Zhang Faming , Wang Huiquan , Chen Ruijuan , Hu Wenzhi , Zhong Yuexia , Wang Xin 
Published: May 2020

Abstract
Fighting on the frontlines against the coronavirus disease 2019 (COVID-19) pandemic, health workers are at high risk of virus infection and overwork-related sudden death and disorders including cardiovascular diseases and stress. When we noted the increase of overwork-related sudden deaths in physicians and nurses in the first 2 weeks after lockdown of Wuhan, we organized the ‘Touching Your Heart’ program by remote monitoring, aiming to protect health workers from overwork-related disorders through integrated volunteer work by physicians and medical engineering researchers from Wuhan Huoshenshan Hospital, Nanjing Medical University, and Tiangong University. By remotely monitoring the health conditions of the medical aid team working at Wuhan Huoshenshan Hospital, the program successfully helped in avoiding severe overwork-related events. The results from our program should be used to remind frontline health workers around the world to take precautions against overworked-related severe events, and show that precision monitoring is effective in improving work efficiency and maintaining a sustainable workforce during emergency situations like a pandemic.
Born sigma model for branes in exceptional geometry
Authors: Sakatani Yuho , Uehara Shozo 
Published: May 2020

Abstract
In double field theory, the physical space has been understood as a subspace of the doubled space. Recently, the doubled space has been defined as the para-Hermitian manifold and the physical space is realized as a leaf of a foliation of the doubled space. This construction naturally introduces the fundamental 2-form, which plays an important role in a reformulation of string theory known as the Born sigma model. In this paper, we present the Born sigma model for $p$-branes in M-theory and type IIB theory by extending the fundamental 2-form into $U$-duality-covariant $(p+1)$-forms.