bluuebunny/crossref_metadata_2025_split huggingface dataset:
La Creatividad y la Planeación Estratégica como factores que impulsan el emprendimiento en la provincia del Cañar, Ecuador
Authors: Ortiz Gonzalez Raul Adrian 
Published: December 2024

El Objetivo de este trabajo de investigación se centra en determinar si la Creatividad y la Planeación Estratégica son factores que impulsan el emprendimiento entre los graduados de la Universidad Católica de Cuenca (UCACUE), en los años 2018 al 2023, específicamente en la provincia del Cañar que tiene extensiones en la Ciudad de La Troncal y Cañar así como una Sede en la ciudad de Azogues. Se destaca la relevancia del emprendimiento como motor de desarrollo económico y la importancia de la educación superior en fortalecerlo. Entre los principales hallazgos se pudo evidenciar que los emprendedores provienen mayormente de la Extensión de La Troncal, los negocios son relativamente pequeños, con un enfoque predominante en el comercio. Utilizando el análisis de la Regresión Lineal Múltiple el estudio demuestra que tanto la Creatividad como la Planeación estratégica son factores determinantes para el éxito empresarial. Estos atributos, adquiridos a través de la formación universitaria y la experiencia práctica, permiten a los emprendedores identificar oportunidades, desarrollar ideas innovadoras y gestionar sus negocios de manera efectiva. Con base a los resultados de esta investigación las entidades provinciales y cantonales podrían adoptar programas de acompañamiento a través de capacitaciones y actualizaciones profesionales al emprendedor desde la apertura de sus negocios hasta su sostenibilidad en el tiempo. De igual manera este trabajo podría sugerir a las Instituciones de Educación Superior (IES) del país a mantener actualizado el pensum académico teniendo en cuenta los aspectos locales y coyunturales del ecosistema empresarial conjuntamente con las nuevas tecnologías
Anemia y su relación con la parasitosis intestinal en niños atendidos en el Hospital del Día Quinindé
Authors: Bajaña Romero Leidy Mishell 
Published: December 2024

Las afecciones relacionadas con la presencia de parásitos afecta de manera considerable a los sistemas de salud a nivel mundial en zonas subdesarrolladas por las condiciones socioeconómicas y sanitarias de la población, los niños constituyen el grupo más vulnerable puede llegar a causar graves consecuencias como la anemia debido a varios mecanismos como el daño de la mucosa intestinal que provoca una reducción de vitaminas, hierro y folatos esenciales para la síntesis de hemoglobina, microhemorragias intestinales que generan pérdida crónica de hierro y procesos inflamatorios crónicos. Estos mecanismos de manera individual o conjunta desencadenan anemia ferropénica o inflamatoria, dependiendo de la severidad y duración de la infección intestinal. Se analizó la relación entre la anemia y la parasitosis intestinal en niños atendidos en el Hospital del Día Quinindé en el periodo 2023-2024, sin embargo, pese a que una gran parte de niños estudiados presentaron parasitosis intestinal, la anemia no fue prevalente y a través de pruebas estadísticas no encontró asociación significativa entre anemia e infección parasitaria. Se sugiere realizar diagnósticos parasitarios oportunos en la población pediátrica tanto a nivel escolar como comunitario porque esta evidencia dará la pauta para el desarrollo de programas específicos sobre todo en grupos altamente vulnerables.
Gerakan Mari Bersalin Ke Fasilitas Kesehatan (MARLIN FASKES)
Authors: Yuliantie Putri , Arbayanti  
Published: December 2024

Pendahuluan: Wilayah kerja Puskesmas Lanjas jumlah ibu hamil dari data kunjungan K4 dari bulan Januari-Juni didapatkan 164 ibu hamil. Beberapa ibu hamil belum menempelkan stiker dan belum mengerti terkait pentingnya stiker P4K serta implementasi dari program itu sendiri, sehingga pentingnya dilakukan upaya dalam memberikan pemahaman dan edukasi tentang Program Perencanaan Persalinan dan Pencegahan Komplikasi (P4K) dengan Stiker
Tujuan: Memberikan edukasi kepada ibu hamil agar bersalin ke fasilitas kesehatan dan ditolong oleh tenaga kesehatan.
Metode: Metode yang digunakan adalah metode sosialisasi dan diskusi. Materi diberikan melalui media poster. Sasaran ibu hamil.
Hasil: Kegiatan ini telah dilakukan pada 25 September 2024 di wilayah UPTD Puskesmas Lanjas, kegiatan yang dilakukan dengan sasaran adalah 15 ibu hamil serta dihadiri oleh bidan. hasil evaluasi sumatif dan formatif peserta yang hadir mampu menjawab dari pertanyaan yang dilakukan oleh pemateri dan peserta mampu memberikan feedback.
Simpulan: Edukasi dan dorongan kepada ibu hamil terkait program Perencanaan Persalinan dan Pencegahan Komplikasi (P4K) dengan Stiker dengan Ibu Hamil Bersalin Wajib Ditolong Tenaga Kesehatan terlaksana dengan baik dan dengan antusias yang tinggi dari peserta sehingga dapat meningkatkan kesadaran dan perilaku terkait gerakan bersalin ke pelayanan kesehatan.
ECOS DA POETICIDADE DA PRESENÇA-AUSÊNCIA DA VOZ DE MULHERES EM O REMORSO DE BALTAZAR SERAPIÃO, DE VALTER HUGO MÃE
Authors: Lourencao Cristiane Corsini , Cardoso Elizabeth 
Published: December 2024

O artigo pretende refletir sobre a voz feminina, em sua ausência, presença ou rememoração, como estratégia de resistência na narrativa de o remorso de baltazar serapião (2018), de Valter Hugo Mãe. Para tanto, investiga-se, a partir dos postulados de Bakhtin (2020), a arquitetônica do conflito entre vozes narrativas constituídas no heterodiscurso e as metáforas resultantes desse recurso estético, em diálogo com pesquisadores contemporâneos (Figueiredo, 2020; Bosi, 1997). Considera-se que a produção de sentido do texto se dá além da temática e é elaborada na/pela linguagem, por isso chega-se em resultados que apontam a voz feminina como relevante irradiadora de poeticidade.
Koszty metod wzmocnienia podłoża w budownictwie drogowym - wyniki badań opinii inwestorów oraz przedsiębiorstw branżowych
Authors: Świtała Marcin , Cichos-Kabut Renata 
Published: December 2024

Artykuł ma charakter badawczy i koncentruje się na analizie oraz ocenie kosztochłonności różnych metod wzmocnienia podłoża w budownictwie drogowym. Podstawę źródłową stanowią wyniki badań opinii respondentów. Badanie przeprowadzono wśród szerokiego grona inwestorów oraz przedsiębiorstw branżowych reprezentujących różne segmenty rynku budownictwa drogowego. W analizie uwzględniono szeroki wachlarz technologii, w tym kolumny betonowe, stabilizacje chemiczne czy pale prefabrykowane. Wyniki badań wskazują, że kosztochłonność różni się w zależności od zastosowanej metody, choć w większości przypadków pozostaje na poziomie zbliżonym, odpowiadając standardowym kosztom wzmocnienia podłoża przyjętym w branży. Metody charakteryzujące się wyższymi kosztami, takie jak palowanie i kolumny betonowe, znacząco wpływają na łączne koszty inwestycji drogowych. Zidentyfikowano istotne różnice w postrzeganiu tych kosztów między inwestorami a przedsiębiorstwami branżowymi, co sugeruje, że wykonawcy usług mogą mieć inną perspektywę na koszty związane z wzmocnieniem podłoża. Artykuł omawia również możliwości optymalizacji kosztów wzmocnienia podłoża, a także przedstawia zalecenia mające na celu poprawę efektywności kosztowej oraz zwiększenie trwałości inwestycji drogowych.
Gender Disparity in Extracurricular Participation: Assessing Impact of Cultural Norms/Practices on Girls’ Participation in Extracurricular Activities of Secondary Schools in Korogwe District, Tanzania
Authors: Msoffe Rahma Mohamed 
Published: December 2024

Education studies admitted that extracurricular activities have played a key role in academic performance and overall education development. Extracurricular involvement among students has been shown to enhance academic performance and increase motivation for further study (Kravchenko and Nygård, 2022). Students who participate in after-school programs at their respective schools are able to apply the skills they learn to other disciplines and to their everyday life (Hayes, 2014). However, gender and education studies asserted that there is gender disparity in participation in extracurricular school activities girls indicated to have poor status compared to boys (Lundh, 2022; (Jägerbrink et al, 2022).
This study therefore assessed influence of cultural norms/practices on girls’ participation in extracurricular school activities. Specifically the study was guided by the following objectives: to identify types of cultural norms/practices that hinder girls’ participation in extracurricular activities, assess influence of pointed out cultural norms/practices on girls’ participation in extracurricular school activities and examine effect of limited girls’ participation in extracurricular activities.
This study used concurrent mixed methods research design to allow collection of qualitative and quantitative data at the same time.
The study used simple random and purposive sampling techniques to obtain a sample size of 120 respondents for quantitative and qualitative data. Data analysis involved thematic analysis for qualitative data and descriptive statistics for quantitative findings. Findings from this study noted that there is gender disparity in extracurricular activities participation whereas girls maintain poor status of participation. The observed gender gap was highly contributed by some of cultural norms/practices, gendered division of domestic roles being the leading factor. Result from this study further indicated that limited participation in extracurricular school deprives girl students an opportunity to grow academically and develop their career.
Method for the determination of 1,3‐butadiene in workplace air using headspace GC [Air monitoring methods, 2019]
Authors: Krämer W. , Brock T.H. , Hebisch R. , Hartwig A. ,   MAK Commission
Published: November 2019

Abstract

This analytical method is a validated measurement procedure for the determination of 1,3‐butadiene [
106‐99‐0
] in workplace air averaged over the sampling period after personal or stationary sampling. Sampling is performed by drawing a defined volume of air through a charcoal tube using a suitable flow‐regulated pump. The flow rate is set to 40 mL/min with a recommended air sample volume of 20 L. The collected 1,3‐butadiene is desorbed with a mixture of benzyl alcohol/dimethyl sulfoxide/water (90+5+5 v:v) and then analysed by means of headspace‐GC and a mass selective detector (MSD). The quantitative evaluation is based on a calibration function obtained by means of a multiple‐point calibration using dichloromethane‐D
2
as internal standard. Based on the resulting peak areas the respective mass of 1,3‐butadiene can be obtained from the calibration function. The absolute limit of quantification (LOQ) is 0.5 µg for 1,3‐butadiene deposited on a charcoal tube. The mean recovery was 84% and the expanded uncertainty for 1,3‐butadiene was between 21 and 23%.

Joint Publication of the Analytical Subcommittee of the Chemistry Board of Experts of the Expert Committee Raw Materials and Chemical Industry of the German Social Accident Insurance and the working group “Air Analyses” of the Permanent Senate Commission of the Deutsche Forschungsgemeinschaft for the Investigation of Health Hazards of Chemical Compounds in the Work Area.
Hydrogen peroxide [MAK Value Documentation, 2019]
Authors: Hartwig A. ,   MAK Commission
Published: November 2019

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) of hydrogen peroxide [
7722‐84‐1
] as new inhalation studies are available.

Hydrogen peroxide is an irritant to the respiratory tract and the eyes.

In a 90‐day inhalation study in the rat a NOAEC of 7 ml/m
3
was determined, which confirms the previous 28‐day inhalation study and proves that the effects at the respiratory tract do not increase with exposure duration.

A new study of acute effects in volunteers suggests that hydrogen peroxide is slightly irritating at 2.2 ml/m
3
, but not at 0.5 ml/m
3
. These findings support all previously described results of inhalation studies in workers or volunteers.

Based on the NOAEC established for humans, the MAK value of 0.5 ml/m
3
is retained.

Peak Limitation Category I and the excursion factor of 1 are retained as there are no new data.
A new interval diagnosis method: Application to the spacecraft rendezvous phase of the Mars sample return mission
Authors: Gueddi Imen , Nasri Othman , Ben Othman Kamel 
Published: November 2019

SummaryThis paper presents a new optimized interval principal component analysis applied to detect and isolate actuators faults of an autonomous spacecraft involved in the rendezvous phase of the Mars sample return mission. Based on the exploitation of various arithmetic and interval analysis properties, the new interval model is built by solving the interval eigenpairs problem via a resolution of a parametric linear programming problem. The detection and isolation phases are performed by extending the classic methods to interval‐valued data. The proposed method is applied to detect and isolate actuators faults that can occur on the spacecraft's thrusters. Based on data provided by a “high fidelity” industrial simulator developed by Thales Alenia Space, the obtained results proved the effectiveness of the proposed interval fault diagnosis method on detecting and isolating thrusters' faults.
A Nanocellulose‐Paper‐Based SERS Multiwell Plate with High Sensitivity and High Signal Homogeneity
Authors: Chen Longyan , Ying Binbin , Song Pengfei , Liu Xinyu 
Published: November 2019

AbstractPaper‐based surface‐enhanced Raman scattering (SERS) substrates have gained growing interest as an eco‐friendly and low‐cost tool for chemical and biosensing. However, paper‐based SERS substrates often suffer relatively low signal spatial homogeneity because of their nonuniform hot‐spot distribution. In this paper, a nanofibrillated cellulose paper (nanopaper) based SERS multiwell plate is developed for trace chemical detection with high sensitivity and high signal homogeneity. The SERS plate is fabricated from ultrasmooth (2,2,6,6‐tetramethylpiperidin‐1‐yl)oxyl‐oxidized NFC paper (TO‐nanopaper) through wax‐printing‐based multiwell patterning followed by silver nanoparticle (AgNP) growth based on a successive ionic layer adsorption and reaction (SILAR) process. Taking advantage of the abundance of carboxyl groups on the TO‐nanopaper, uniformly distributed and densely arranged AgNPs are successfully synthesized through the SILAR process on the NFC multiwell surface under ambient conditions. The SERS performance of the device is evaluated for testing two Raman marker chemicals, rhodamine B and 2‐naphthalenethiol, and picomolar detection limit and high Raman enhancement factor (up to 1.46 × 109) are achieved. The Raman signal mapping results show superior signal spatial homogeneity of the device with low variations (≤11%). The nanopaper‐based SERS device represents a promising SERS platform for chemical and biomolecule detections with high sensitivity and high repeatability.
Controlling the Chromaticity of White Organic Light‐Emitting Diodes Using a Microcavity Architecture
Authors: Jeong Soyeong , Jung Suhyun , Kang Hongkyu , Choi Sang‐Bae , Hong Soonil , Lee Jinho , Yu Kilho , Kim Nara , Kee Seyoung , Lee Dong‐Seon , Lee Kwanghee 
Published: November 2019

AbstractThe tailoring of the chromaticity of white organic light‐emitting diodes (WOLEDs) has presented a significant challenge in their application in smart lighting sources to improve the quality of life and human performance. Here, a new microcavity WOLED (M‐WOLED) structure to modulate the chromaticity of the emitted light is demonstrated by only adjusting the thickness of the white light‐emitting layer. By introducing a polymer‐metal hybrid electrode that functions both as a partially reflective mirror and a transparent electrode, a very simple microcavity architecture that does not require additional outer mirrors, such as distributed Bragg reflectors is developed. The resulting M‐WOLEDs exhibit reddish‐, greenish‐, and bluish‐white colors with different thicknesses of the single white light‐emitting layer.
Gold‐Catalyzed Intermolecular Oxidative Diyne Cyclizations via 1,6‐Carbene Transfer
Authors: Wang Qian , Rudolph Matthias , Rominger Frank , Hashmi A. Stephen K. 
Published: November 2019

AbstractA vinyl/α‐oxo carbene is generated via an α‐oxo carbene formation and subsequently transferred across the second alkyne. These highly active species can react with nitriles in an intermolecular fashion to provide substituted oxazoles. This methodology goes through 1,6‐carbene shift and offers a range of valuable products.magnified image
The miR‐193a‐3p‐MAP3k3 Signaling Axis Regulates Substrate Topography‐Induced Osteogenesis of Bone Marrow Stem Cells
Authors: Lv Yan , Huang Ying , Xu Mingming , Heng Boon Chin , Yang Congchong , Cao Cen , Hu Zhewen , Liu Wenwen , Chi Xiaopei , Gao Min , Zhang Xuehui , Wei Yan , Deng Xuliang 
Published: November 2019

AbstractSubstrate topographical features induce osteogenic differentiation of bone marrow stem cells (BMSCs), but the underlying mechanisms are unclear. As microRNAs (miRNAs) play key roles in osteogenesis and bone regeneration, it would be meaningful to elucidate the roles of miRNAs in the intracellular signaling cascade of topographical cue‐induced osteogenic differentiation. In this study, the miRNA expression profile of the topographical feature‐induced osteogenic differentiation group is different from that of the chemical‐factors‐induced osteogenic differentiation group. miR‐193a‐3p is sensitive to substrate topographical features and its downregulation enhances osteogenic differentiation only in the absence of osteogenesis−inducing medium. Also, substrate topographical features specifically activate a nonclassical osteogenetic pathway—the mitogen‐activated protein kinase (MAPK) pathway. Loss‐ and gain‐of‐function experiments demonstrate that miR‐193a‐3p regulates the MAPK pathway by targeting the MAP3k3 gene. In conclusion, this data indicates that different osteogenic‐lineage‐related intracellular signaling cascades are triggered in BMSCs subjected to biophysical or chemical stimulation. Moreover, the miR‐193a‐3p‐MAP3k3 signaling axis plays a pivotal role in the transduction of biophysical cues from the substrate to regulate the osteogenic lineage specification of BMSCs, and hence may be a promising molecular target for bone regenerative therapies.
IL1R2 Blockade Suppresses Breast Tumorigenesis and Progression by Impairing USP15‐Dependent BMI1 Stability
Authors: Zhang Lixing , Qiang Jiankun , Yang Xiaoli , Wang Dong , Rehman Adeel ur , He Xueyan , Chen Weilong , Sheng Dandan , Zhou Lei , Jiang Yi‐zhou , Li Tao , Du Ying , Feng Jing , Hu Xin , Zhang Jian , Hu Xi‐chun , Shao Zhi‐ming , Liu Suling 
Published: November 2019

AbstractBreast tumor initiating cells (BTICs) with ALDH+CD24−CD44+ phenotype are the most tumorigenic and invasive cell population in breast cancer. However, the molecular mechanisms are still unclear. Here, it is found that a negative immune regulator interleukin‐1 receptor type 2 (IL1R2) is upregulated in breast cancer (BC) tissues and especially in BTICs. BC patients with high IL1R2 expression have a poorer overall survival and relapse‐free survival. High IL1R2 promotes BTIC self‐renewal and BC cell proliferation and invasion. Mechanistically, IL1R2 is activated by IL1β, as demonstrated by the fact that IL1β induces the release of IL1R2 intracellular domain (icd‐IL1R2) and icd‐IL1R2 then interacts with the deubiquitinase USP15 at the UBL2 domain and promotes its activity, which finally induces BMI1 deubiquitination at lysine 81 and stabilizes BMI1 protein. In addition, IL1R2 neutralizing antibody can suppress the protein expression of both IL1R2 and BMI1, and significantly abrogates the promoting effect of IL1R2 on BTIC self‐renewal and BC cell growth both in vitro and in vivo. The current results indicate that blocking IL1R2 with neutralizing antibody provides a therapeutic approach to inhibit BC progression by targeting BTICs.
Tuning Butyrylcholinesterase Inactivation and Reactivation by Polymer‐Based Protein Engineering
Authors: Zhang Libin , Baker Stefanie L. , Murata Hironobu , Harris Nicholas , Ji Weihang , Amitai Gabriel , Matyjaszewski Krzysztof , Russell Alan J. 
Published: November 2019

AbstractOrganophosphate nerve agents rapidly inhibit cholinesterases thereby destroying the ability to sustain life. Strong nucleophiles, such as oximes, have been used as therapeutic reactivators of cholinesterase‐organophosphate complexes, but suffer from short half‐lives and limited efficacy across the broad spectrum of organophosphate nerve agents. Cholinesterases have been used as long‐lived therapeutic bioscavengers for unreacted organophosphates with limited success because they react with organophosphate nerve agents with one‐to‐one stoichiometries. The chemical power of nucleophilic reactivators is coupled to long‐lived bioscavengers by designing and synthesizing cholinesterase‐polymer‐oxime conjugates using atom transfer radical polymerization and azide‐alkyne “click” chemistry. Detailed kinetic studies show that butyrylcholinesterase‐polymer‐oxime activity is dependent on the electrostatic properties of the polymers and the amount of oxime within the conjugate. The covalent coupling of oxime‐containing polymers to the surface of butyrylcholinesterase slows the rate of inactivation of paraoxon, a model nerve agent. Furthermore, when the enzyme is covalently inhibited by paraoxon, the covalently attached oxime induced inter‐ and intramolecular reactivation. Intramolecular reactivation will open the door to the generation of a new class of nerve agent scavengers that couple the speed and selectivity of biology to the ruggedness and simplicity of synthetic chemicals.
Near‐Infrared‐Irradiation‐Mediated Synaptic Behavior from Tunable Charge‐Trapping Dynamics
Authors: Wang Yan , Yang Jing , Ye Wenbin , She Donghong , Chen Jinrui , Lv Ziyu , Roy Vellaisamy A. L. , Li Huilin , Zhou Kui , Yang Qing , Zhou Ye , Han Su‐Ting 
Published: November 2019

AbstractParallel information storage coupled with storage density is a major focus for non‐volatile memory devices to achieve neuromorphic computing that can work at low power. In this regard, a photoactive charge‐trapping medium consisting of inorganic heteronanosheets for the fabrication of a synaptic transistor is demonstrated. This synaptic device senses and responds to near‐infrared (NIR) light signals and mimics the memorization and dynamic forgetting process due to the reversible nature of photogenerated charge interaction. Device‐level synaptic evolutions from short‐term plasticity to long‐term plasticity, paired pulse facilitation, and paired pulse depression are realized with light modulation on the weight update terminal. To understand the underlying mechanism of the synaptic behavior under NIR signals, systematic analysis is carried out using in situ atomic force microscopy based electrical techniques. With its photoactive architecture, this information processing analogue is validated for visual object recognition, which paves the way for implementing NIR‐controlled neuromorphic computing.