bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lecithin- cholesterol acyltransferase and relationship with Platelet-activating factor in AB blood phenotype
Authors: Birinci Suayip , Koctekin Belkis , Yilmaz Necat 
Published: November 2020

Objectives: This study aimed to determine the association between Lecithin-cholesterol acyltransferase (LCAT) and Platelet-activating factor (PAF) with atherogenic potential in the ABO blood system.Background: The current study is the first study that focuses on healthy blood donors and investigating a relationship between ABO blood groups and LCAT enzyme and PAF, which plays a notable role in atherogenesis.Methods: ABO blood types characterize the role of the individualistic phenotype. Hence, it is generally assumed that ABO blood phenotypes are involved with many diseases. This cross-sectional study involved 176 healthy subjects with different ABO blood phenotypes. Measurements of routine lipids, LCAT, PAF and atherogenic plasma index (AIP) were performed in these subjects.Results: Our most important finding was that individuals with blood group AB have statistically significant lower LCAT levels in serum. Additionally, there was a moderately negative correlation between LCAT and triglycerides in the AB blood phenotype (r=-0.452, P=0.02). Nevertheless, there were statistically significant correlations between LCAT levels and PAF levels of subjects with only non â€“O blood phenotypes (A, B and AB). Serum AIP values were statistically significantly higher in the AB blood group.Conclusion: The present study suggests that blood group AB can be associated with decreased LCATÂ Â levels when compared to the non- AB phenotypes. We suggest that LACT and AIP may be helpful biomarkers to illustrate atherogenic risk in AB blood phenotype, although this requires further investigation.
Healthy food to support healthy life
Authors: Pinatih Gde Ngurah Indraguna 
Published: November 2020

Healthy, happy, success and long life are everyone's dream of being. To have these, proper nutrition is one of the basic needs that must be metâ€”food composing of nutrients and non-nutrients that will influence the quality of food. Hence, Food must meet four conditions to be said as healthy food. It has to be adequate, balance in the composition of nutrients, calorie in control, and free or at least within the safety level of health hazard components. Yet, food does not affect directly on oneâ€™s health but the diet, though it takes time from unhealthy habit into getting the disease or vice versa.Â Since food has many functions in human life, moderation and variety becoming very important to compose a healthy diet. If these six principals are put into the habit, then fit, and well-being can be promised so far unless some other risk factors can affect health.Â Water has a crucial role in supporting the body function, and human cannot avoid drink in daily life. Still, beverage drinks can be easily slipped into the hazardous substrate that will influence on health. Knowledge on nutrigenomic is worth to be applied to have more on the personal approach of how food and diet can affect health.
The effects of meldonium on microrheological abnormalities of erythrocytes in rats with obesity : An experimental study
Authors: Kulikov Evgeny Vladimirovich , Zavalishina Svetlana Yuryevna , Vatnikov Yury Anatolyevich , Seleznev Sergey Borisovich , Parshina Valentina Ivanovna , Voronina Yuliya Yurevna , Popova Irina Anatolyevna , Bondareva Irina Viktorovna , Petrukhina Olesia Anatolyevna , Troshina Natalya Igorevna , Glagoleva Tatyana Ivanovna 
Published: November 2020

Background: The microrheological disorders of red blood cells in obesity is often missed by the researchers. This study aimed to report an experimental investigation on laboratory animals with developed obesity and to find out the effect of meldonium on the erythrocytes.Methods: A total of 95 healthy male-rats of Vistar line were taken into the investigation, 29 animals had experienced no impacts and allocated as the control group, while 64 rats which had developed obesity induced by a cardioangionefopathogenic semisynthetic diet into the obesity group. These rats were casually divided into an experimental (34 rats) group and the control group (30 rats). The rats of the experimental group in the next ten days were intragastrically injected with meldonium for 80 mg/kg. The biochemical, hematological and statistical methods of investigation were used in this study.Results: During the formation of obesity and the use of meldonium, the body weight of the rats were gradually decreased to the normal level. On the obese rat's group receiving meldonium, the content of the lipids peroxidation products in erythrocytes progressively decreased. Â and reached the level of the healthy control rats group. Moreover, there was a decrease in the number of erythrocytes-discocytes accompanied by an increase in the reversible and irreversible changes. These values were returned to the level of the healthy control rats group at the end of the observation. This pattern was observed in the total number of erythrocytes aggregate and free erythrocytes.Conclusion: The application of meldonium eliminates the existing erythrocytes abnormal microrheological features in the rats with recently developed obesity.
The in-vivo anti-inflammatory effect of red earthworm (Lumbricus rubellus) ethanolic extract from organic farmland in Bali, Indonesia
Authors: Dewi Ni Wayan Sucindra , Mahendra Agung Nova 
Published: November 2020

Background: One of the typical responses to the protection of the body is inflammation. Extensive and severe inflammation can result in tissue damage. Earthworms have been used empirically for years to treat diseases that are based on inflammatory events. This study evaluates the anti-inflammatory properties of red earthworm (Lumbricus rubellus) ethanolic extract from organic farmland in Bali, Indonesia.Methods: An experimental study by post-test only control group design was conducted among 30 adult male Wistar rats, divided into 6 groups. Each group was given 0.5% NaCMC (negative control), Diclofenac sodium 9 mg/kgBW (positive control), Red earthworm ethanolic extracts of 50 mg/kgBW (P1) and 100 mg/kgBW (P2) at 1 hour before carrageenan injection. In addition, the ethanolic extracts of Red earthworms, respectively 50 mg/kgBW (P3) and 100 mg/kgBW (P4), which had been given once a day, during 1 week before and at the eighth day 1 hour before carrageenan injection. The measurements of edema were performed 4 hours after the administration of the test material. Data were analyzed using SPSS version 20 for Windows.Results: The median score of Rats Hind Paw Edema was 0.3 (0.2-0.4) ml in negative control, 0.1 (0.0-0.2) ml in positive control, 0.2 (0.1-0.2) ml in P1, 0.2 (0.1-0.3) ml in P2, 0.2 (0.1-0.2) ml in P3, and 0.1 (0.1-0.2) ml in P4 groups. There was a significant differences between the NaCMC group (negative control) with the Diclofenac sodium group (positive control), P1, P3, and P4 groups (p<0.05), but not with P2 group (p>0.05).Conclusion: Â We conclude that red earthworm (Lumbricus rubellus) ethanolic extract from Bali's organic farmland exhibits an anti-inflammatory effect.
Management of von willebrand disease in pregnancy in resource-limited settings: a case report
Authors: Adnyana I Wayan Losen 
Published: November 2020

Background: Von Willebrand's disease (VWD) is the most common autosomal dominant bleeding disorder. Pregnancy and delivery in patient with VWD possess significant clinical challenges.Case description: a 24-year-old woman who will undergo labor with a history of VWD.Â The patient was planned for induction of vaginal delivery and has been given intranasal desmopressin, cryoprecipitate, and factor VIII from before delivery to 5 days after delivery. Labor occurs without excess bleeding. The patient was monitored for 6 days after delivery, and there is no complication of excessive bleeding.Conclusion: This case emphasizes how to manage Von Willebrand's disease in pregnancy with limitation in the examination and therapeutic option, also the importance of joint management from the hematologist, obstetrician, starting from the antepartum, delivery, and postpartum phases.
Pola Mikroba dan Sensitivitasnya Terhadap Antibiotik pada Pasien dengan Infeksi Saluran Kemih di RSUD Prof. Dr. W.Z. Johannes, Kupang Periode Januari-Desember 2017
Authors: Anggelia Vivi , Oktavia Clarissa , Sutrisno Heri , Indita Hermi 
Published: November 2020

Background: Urinary tract infection (UTI) is a serious public health problem which involves infection of any parts of the urinary tract. In the past few years, treatment of UTI becomes very challenging due to increase emergence of antibiotics resistance in uro-pathogens. This study was performed to determine microbial patterns and its sensitivity to antibiotics.Methods: This was an observational descriptive study. The data were collected from 130 urine samples in RSUD Prof. Dr. W.Z. Johannes during period of January-December 2017. Patients were diagnosed UTI by using Vitek 2.Results: We obtained 130 samples of urine culture in RSUD. Prof. Dr. W. Z. Johannes during period of January-December 2017. From 130 samples of urine culture, 83 samples showed growth of bacteria and fungi (63,85%) whereas 47 samples showed no growth (36,15%). From 83 growth samples, we identified 20 types of bacteria which include 4 types of gram positive bacteria, 16 types of gram negative bacteria and 1 type of fungi. The most common causes of UTI were E. coli (22,89%), Candida albicans (10,84%), Klebsiella pneumoniae ss pneumoniae (9,64%) and Acinetobacter baumanii (6,02%). Meropenem, gentamycin and amikacin were still sensitive to uropathogen. The most common antibiotics which were resistance to bacteria were ampicillin and ceftriaxone.Conclusion: Escherichia coli is the most prevalence contribute to UTI in outpatient and inpatient. There were only three types of non-resistant antibiotic to uropathogens.Â Latar Belakang: Infeksi saluran kemih (ISK) merupakan salah satu masalah kesehatan serius. Beberapa tahun belakangan ini, pengobatan ISK menjadi tantangan tersendiri bagi para klinisi karena tingginya angka resistensi antibiotik. Penelitian ini bertujuan untuk mengetahui pola mikroba dan senstivitasnya terhadap antibiotik.Metode: Pada penelitian deskriptif observasional ini, didapatkan 130 sampel urin di RSUD Prof. Dr. W.Z. Johannes dari bulan Januari-Desember 2017 dimana pasien didiagnosis ISK melalui pemeriksaan dengan Vitek 2.Hasil: Sebanyak 130 sampel urin yang dikultur, 83 sampel menunjukan perkembangan bakteri dan jamur (63,85%) dimana 47 sampel menunjukan tidak adanya pertumbuhan (36,15%). Dari 83 sampel yang tumbuh, teridentifikasi sebanyak 20 tipe bakteri dimana 4 tipe merupakan gram-positif dan 16 tipe gram negatif serta 1 tipe jamur. Penyebab terbanyak ISK adalah E. coli (22,89%), Candida albicans (10,84%), Klebsiella pneumoniae ss pneumoniae (9,64%) dan Acinetobacter baumanii (6,02%). Dimana antibiotik jenis meropenem, gentamisin dan amikasin masih sensitif untuk uropatogen. Sedangkan ampisilin dan seftriakson adalah jenis antibiotik yang memiliki angka resistensi tertinggi.Kesimpulan: Escherichia coli adalah penyebab tersering ISK dan hanya ditemukan tiga jenis antibiotik yang masih sensitif untuk uropatogen.
Vitamin C and ubiquinone have the same ability in reducing the spermatozoa DNA fragmentation index in infertile men at Doctor Soetomo General Hospital, Surabaya, Indonesia
Authors: Halim Ayang , Supardi Supardi , Lunardhi Hamdani 
Published: November 2020

Background:Â Infertility is one of the most common health problems in the world. Malefactors contribute to 50% of cases and about 15-30% of infertile men are categorized as unexplained infertility. There have been numerous studies investigating the role of spermatozoa DNA fragmentation in male infertility. Spermatozoa nuclear DNA integrity has been suggested as a better predictor of male infertility and oxidative stress has been known related to it. This study was conducted to determine the oral supplementation of Vitamin C and Ubiquinone in reducing the spermatozoa DNA fragmentation index (DFI) among infertile men.Â Methods:Â This was an experimental clinical trial with a pre-test and post-test group design. Thirty infertile men were randomized double-blindingly into 3 groups: Vitamin C and Ubiquinone; Vitamin C and Placebo; Ubiquinone and Placebo groups, each treatment was given for 35 days. The DFI was evaluated by Sperm Chromatin Dispersion (SCD) test, before and after treatment. Data were analyzed using SPSS version 21 for Windows.Results:Â The average age of respondents was 32.6 years old, followed by 4.6 years of infertility duration in 5.8 years of marriage. Most of the respondents had a normal Body Mass Index (BMI) (46.7%), no smoking history (75.0%), no history of heat (90.0%) or chemical (73.3%) exposure, and diagnosed with primary male infertility (90.0%). Vitamin C group showed a significant reduction in the spermatozoa DFI (95% CI, p<0.05), while the other two groups showed no differences in the spermatozoa DFIs (95% CI, p>0.05). Comparison analysis showed no differences in the reduction of the spermatozoa DFIs (95% CI, p>0.05) among these three groups.Â Conclusion:Â The recent findings suggest that oral supplementation of vitamin C can reduce the spermatozoa DFI, while ubiquinone and the combination of vitamin C and ubiquinone could not reduce the spermatozoa DFI.
Efek pemberian ekstrak etanol bawang putih (Allium sativum) sebagai hepatoprotektor pada tikus putih jantan galur wistar (Rattus norvegicus) yang diinduksi parasetamol dosis hepatotoksik
Authors: Harsa Made Subhawa 
Published: November 2020

Garlic (Allium sativum) is a plant that known to have various properties that can be used in treatment as a hepatoprotective agent. This study aim was to determine the effect of garlic ethanol extract (Allium sativum) in Wistar strain white male rats (Rattus norvegicus) which was induced by paracetamol in hepatotoxic dose. This research is an experimental study with randomized the post-test only control group design with sample consisted of twenty-four Wistar strain white male rats (Rattus norvegicus). The sample were divided into four groups: control groups, group P1 (given garlic ethanol extract 10 mg/kg), group P2 (ethanol extract of garlic was given 20 mg/kg) and group P3 (given the ethanol extract garlic 30 mg/kg). This study for seventeen days. The entire samples were terminated in order to draw blood to examine SGPT and SGOT. The data of SGPT and SGOT examined by One Way ANOVA. Result showed that there was significant difference in SGPT and SGOT values between groups after given ethanol extract of garlic (Allium sativum) (Î± <0.05). From the analysis we can concluded that garlic ethanol extract (Allium sativum) can be used as a hepatoprotective agent in Wistar strain white male rats (Rattus norvegicus) Â induced by paracetamol in hepatotoxic dose.
Karakteristik klinikopatologi osteosarkoma berdasarkan usia, jenis kelamin, lokasi, dan tipe histopatologi di Laboratorium Patologi Anatomi RSUP Sanglah Denpasar tahun 2012 -2016
Authors: Aryanda Putra Putu Agus , Susraini Anak Agung Ngurah , Sumadi I Wayan Juli 
Published: November 2020

Background: Osteosarcoma was the most common primary bone tumor, and there are only a few studies discussed the clinicopathological characteristics of Osteosarcoma.Aim: This study aimed to determine the clinicopathological features of Osteosarcoma based on age, sex, type, and the location in Anatomical Pathology Laboratories Sanglah Hospital Denpasar in 2012 â€“ 2016.Method: This research was a cross sectional descriptive study which obtains data from the medical record in Anatomical Pathology laboratories Sanglah Hospital Denpasar in 2012 â€“ 2016. The total sample is 44 cases by total sampling technique. The data were processed using SPSS version 20.Result: In this study, the majority of Osteosarcoma patients were in age group 0 â€“ 24 years as many as 30 cases (68.2%) and rarely found in the age group 49 -72 years for 2 cases (4.5%). Osteosarcoma was slightly higher in a male about 23 cases (52.3%) and 21 cases in female (47.7%).Conclusion: the Histopathological type that mostly found was Conventional Osteosarcoma as many as 41 cases (93.2%) and the most common site of Osteosarcoma was in femur about 24 cases (52.2%).Â Osteosarkoma merupakan tumor primer pada tulang yang paling sering ditemukan, namun tidak banyak penelitian yang hanya membahas karakteristik klinikopatologi Osteosarkoma.Tujuan: Tujuan penelitian ini adalah untuk mengetahui karakteristik klinikopatologi Osteosarkoma berdasarkan usia, jenis kelamin, tipe, dan lokasi di Laboratorium Patologi Anatomi RSUP Sanglah RSUP Sanglah Denpasar pada tahun 2012 â€“ 2016.Metode: Penelitian ini merupakan studi deskriptif cross sectional yang dilaksanakan di Laboratorium Patologi Anatomi RSUP Sanglah Denpasar menggunakan catatan rekam medis periode tahun 2012 -2016. Teknik pengambilan sampel menggunakan total sampling, dengan total jumlah sampel sebanyak 44 orang. Data diolah menggunakan SPSS versi 20. PenderitaHasil: Osteosarkoma pada penelitian ini paling sering ditemukan pada kelompok usia 0 â€“ 24 tahun sebanyak 30 kasus (68,2%) dan paling sedikit pada kelompok usia 49 â€“ 72 tahun terdapat 2 kasus (4,5%). Jumlah kasus Osteosarkoma sedikit lebih tinggi kasusnya pada pria yaitu, sebanyak 23 kasus (52,3%) sedangkan pada wanita ditemukan sebanyak 21 kasus (47,7%).Simpulan: Tipe histopatologi yang paling sering ditemukan adalah Conventional Osteosarcoma sebanyak 41 kasus (93,2%) dan lokasi tersering pada tulang femur sebanyak 24 kasus (52,2%).
Kualitas tidur pada sekuriti hotel dengan jadwal jaga malam di Kota Denpasar tahun 2017
Authors: Prasetya Mia Felina , Gotera Wira , Putrawan Ida Bagus Putu 
Published: November 2020

Background: Globalization forces some people to work at night, the time that should be dedicated for rest. Many health consequences have to be faced because of the night shift work, one of which is sleep quality.Aim: This study was performed in Denpasar City in 2017 to assess the sleep quality of night shift workers.Methods: This study was a descriptive and observational study by using questionnaires. Population of this study was hotel security officer in Denpasar City with samples of 85 subjects.Results: From 85 subjects investigated, 67.1% sample was categorized as poor sleep quality subjects and 32.9% was categorized as good sleep quality subjects. With total PSQI score above five as cut off, the mean was found at 7.26 and median was 7. In addition, the minimum PSQI score for this study was 2 and maximum PSQI score was 17.Conclusion: It can be concluded that quality of sleep on night shift workers that being represented by hotel security, still belonged to poor sleep quality.Â Â Latar belakang: Globalisasi telah memaksa sebagian orang untuk bekerja di malam hari, waktu yang sebenarnya adalah waktu untuk beristirahat. Dampak-dampak kesehatan pun bermunculan dikarenakan jadwal jaga malam ini, salah satunya adalah pada kualitas tidur.Tujuan: Penelitian ini dilakukan di Kota Denpasar tahun 2017 untuk mengetahui gambaran kualitas tidur pada pekerja dengan jadwal jaga malam.Metode: Penelitian ini menggunakan metode deskriptif observasional dengan pemberian kuesioner. Populasi penelitian ini adalah sekuriti hotel di Kota Denpasar dengan jumlah sampel 85 subyek.Hasil: Dari 85 sampel yang diperiksa didapatkan 67,1% sampel dengan kualitas tidur yang buruk dan kualitas tidur yang baik sebesar 32,9% dari sampel. Dengan skor total PSQI di atas lima sebagai batasan, telah didapatkan mean sebesar 7,26 dan median sebesar tujuh. Didapatkan juga skor PSQI minimum yang ada sebesar dua dan skor maksimum sebesar 17.Kesimpulan: Kualitas tidur pada pekerja jadwal jaga malam yang diwakilkan oleh sekuriti hotel masih tergolong buruk.
Pemberian ekstrak kulit buah anggur (Vitis vinifera L.) mampu menurunkan kadar malondialdehid (MDA) plasma pada tikus dengan diet tinggi kolesterol
Authors: Nurhidayati Etik , Linawati Ni Made , Sugiritama I Wayan 
Published: November 2020

Introduction: High cholesterol levels will cause disease, one of which is cardiovascular disorders or diseases. Based on WHO data in 2012 there were 17.5 million deaths in the world due to cardiovascular disease. Coronary heart occupies the highest position at 42% where one of the most common risk factors is dyslipidemia. This research aimed to evaluate the effect of grape skin extract on plasma MDA level.Methods: This study is an experimental study with a post-test only control group research design. Thirty male Wistar rats aged 2-3 months with a body weight of around 200 grams and healthy, classified into 4 treatment groups and a control group with a high cholesterol diet and administration of different dosages of grape skin extract, dose of 100 mg/175 gbw (gram body weight), 250 mg/175 gbw, and 500 mg/175 gbw. All blood samples were taken on day 30 and an MDA test was performed. Kruskal Wallis test was performed to analyze the correlation.Results: The test results obtained with p<0.05 in the group of rats given grape skin extract at a dose of 100 mg/175 gbw, 250 mg/175 gbw, and 500 mg/175 gbw, thus showing significantly lower MDA levels compared with control group.Conclusion: Administration of grape skin extract to rats given a high cholesterol diet may reduce plasma MDA levels.Â Latar belakang: Kolesterol yang tinggi di dalam darah akan mengakibatkan berbagai masalah kesehatan, salah satunya adalah gangguan atau penyakit kardiovaskular. Data tahun 2012 terdapat 17,5 juta kematian di dunia karena masalah kardiovaskular. Jantung koroner menduduki posisi tertinggi yaitu 42% dimana salah satu faktor risiko terseringnya adalah dislipidemia. Mengetahui dampak pemberian kulit buah anggur terhadap MDA plasma tikus adalah sasaran penelitian ini.Metode: Sebuah penelitian eksperimental menggunakan metode post-test only diterapkan pada penelitian ini. Tiga puluh tikus wistar jantan, umur 2-3 bulan, berat rerata 200 gram, dan sehat, dikelompokkan ke dalam 1 kelompok kontrol serta 4 kelompok perlakuan dengan diet tinggi kolesterol dan pemberian dosis ekstrak kulit anggur yang berbeda-beda, yaitu dosis 100 mg/175 gbb, 250 mg/175 gbb dan 500 mg/175 gbb. Pada akhir penelitian, yaitu hari ke- 30, semua sampel diambil darahnya kemudian dilakukan uji MDA.Hasil: Uji penelitian dengan Kruskal Wallis memperoleh hasil p=0,035 (p<0,05) pada kelompok tikus yang diberikan ekstrak kulit anggur dengan dosis 100 mg/175 gbb, 250 mg/175 gbb dan 500 mg/175 gbb, sehingga menunjukkan kadar MDA lebih rendah signifikan dibanding dengan kontrol.Simpulan: Pemberian ekstrak kulit buah anggur memiliki dampak penurunan MDA plasma pada tikus dengan diet tinggi kolesterol.