bluuebunny/crossref_metadata_2025_split huggingface dataset:
DIVERSIFIKASI USAHA USAHA SANGGAR SENI UNTUK MENINGKATKAN KESEJAHTERAAN
Authors: Anoegrajekti Novi , Asrumi Asrumi , Macaryus Sudartomo , Maharani Hanni Miladia 
Published: April 2020

Sanggar Tari “Sayu Sarinah” sebagai salah satu pengembang perajin asesoris memiliki potensi untuk berkembang namun mengalami keterbatasan ketrampilan untuk usaha mandiri. Kurangnya ketrampilan pembuatan asesoris dan cindera mata maupun kemampuan pengelolaan atau manajemen dalam proses produksi yang terbatas membuat kegiatan Sanggar belum optimal.
Kegiatan ini ditujukan untuk mengatasi permasalahan tersebut dengan cara: (1) memberikan penyuluhan dan pelatihan peningkatan ketrampilan pembuatan asesoris dan cendera mata bernuansa seni gandrung berbahan baku perak dan inovasinya; (2) penyuluhan pentingnya manajemen usaha asesoris dan cendera mata secara mandiri. Sasaran kegiatan ini adalah para pemuda yang ada di sekitar Sanggar “Sayu Sarinah”. Kegiatan ini dilaksanakan melalui penyuluhan, pelatihan, dan pendampingan praktik. Metode pelaksanaannya adalah ceramah, tanya jawab, demonstrasi, dan latihan atau praktik pembuatan asesoris dan cendera mata mahkota gandrung berbahan baku perak. Dengan cendera mata motif gandrung menguatkan posisi gandrung sebagai maskot pariwisata dan identitas Banyuwangi.
Influence of non-ferrous metals on the structural quality of the high-alloy mild steel 20X2H4A billets received by centrifugal electroslag remelting
Authors: Papkovskiy P. I. , Valko A. I. , Sandomirskii S. G. 
Published: April 2020

The problem of the formation of cracks and the conditions of their origin in the cast of metal products have been widely studied in world practice, but the real mechanism of this process is not yet clear enough that it could be applied in production. Hot cracks – one of the most common and the most detrimental defects of steel castings, leading to a significant increase in the cost of products. The formation of hot cracks in steel castings depends on many factors, including the chemical composition of steel, the presence of non-metallic inclusions and gases, conditions of deoxidation and solidification of steel, etc. Therefore, special attention in the real conditions of production should be given to the metallurgical side of the issue. There is no quantitative measure of steel purity in the books of steel, which is divided into chemical, defined by the chemical analysis, and metallographic, defined by the content of non-metallic inclusions. The effect of the general purity of steel on the characteristics of destruction is studied sufficiently, but the data on the individual impact of impurities is very incomplete.In many respects, pure steel has a clear advantage over steel with harmful impurities. This applies to all mechanical properties associated with destruction or processes occurring on the edge of grains. The cardinal way of obtaining cleaner steel, including the reduction of impurities of non-ferrous metals, is the use of pure original charge mixture.The article discusses the topical problem of cracking formation after chemical-thermal treatment in the material of sun gears of the second row of quarry dump trucks BELAZ, obtained by the method of CESR rolled steel 20X2H4А, the possible impact of small concentrations of non-ferrous metals (Pb, Zn, Sn, Bi, As, Se) on the development of external and internal cracks in castings and on structural heterogeneity of steel after CESR.The obtained results allowed to draw conclusions about the impact of non-ferrous metals on the formation of cracks in castings and to establish their limited quantitative characteristics. Based on the results, measures have been proposed to minimize the impact of small amounts of non-ferrous metals on the formation of cracks in castings.
Why under five children are stunted in Pakistan? A Multilevel analysis of Punjab Multiple Indicator Cluster Survey (MICS-2014)
Authors: Mahmood Tahir , Abbas Faisal , Kumar Ramesh , Somrongthong Ratana 
Published: April 2020

Abstract
Background: Pakistan is facing an acute problem of child under-nutrition as about 38% of children in Pakistan are stunted. Punjab, the largest province by population and GDP share having a stunting prevalence of about 33.5% moderately and 13.3%severely stunted children of less than five years. Thus, this study aims at examining the determinants of stunting (moderate and severe) at different level of hierarchy empirically.Methodology: Data for this study is coming from Punjab Multiple Indicators Cluster Survey (MICS-2014). MICS uses a two-stage, stratified cluster sampling approach. MICS is sub-national level (Punjab province) data covering urban and rural areas. The data consists of 25,067 children under five, for 9 administrative divisions and 36 districts of Punjab province of Pakistan. Descriptive statistics and multilevel hierarchical models were estimated. Multilevel data analyses have an advantage because it provides robust standard error estimates and helps in finding variation in the data at various levels. Results: Punjab has a stunting prevalence of about 27% moderately and 10% severely stunted children of less than five years. The results depict that increasing the age of the child, increasing birth order, illiterate mothers and fathers, lack of sanitation facilities and being poor are associated significantly with the likelihood of moderate and severe stunting. Surprisingly, there is a gender bias in stunting in Punjab, Pakistan and being a girl child is more likely associated with moderate and severe stunting, which depicts the patriarchal nature of the society and a substantial prevalence of gender bias in household resource allocations.Conclusion: This outcome of our analysis points towards targeting not only households (focus on girls) but also their families and communities.
Problematic Internet Use in Children and Adolescents: Associations with psychiatric disorders and impairment
Authors: Author) Anita Restrepo(Former Corresponding , Scheininger Tohar , Clucas Jon , Alexander Lindsay , Salum Giovanni , Georgiades Kathy , Paksarian Diana , Merikangas Kathleen , Author) Michael Milham(New Corresponding 
Published: April 2020

Abstract
Background: Problematic internet use (PIU) is an increasingly worrisome issue, as youth population studies are establishing links with internalizing and externalizing problems. There is a need for a better understanding of psychiatric diagnostic profiles associated with this issue, as well as its unique contributions to impairment. Here, we leveraged the ongoing, large-scale Child Mind Institute Healthy Brain Network, a transdiagnostic self-referred, community sample of children and adolescents (ages 5-21), to examine the associations between PIU and psychopathology, general impairment, physical health and sleep disturbances.Methods: A total sample of 564 (190 female) participants between the ages of 7-15 (mean = 10.80, SD = 2.16), along with their parents/guardians, completed diagnostic interviews with clinicians, answered a wide range of self-report (SR) and parent-report (PR) questionnaires, including the Internet Addiction Test (IAT) and underwent physical testing as part of the Healthy Brain Network protocol. Results: PIU was positively associated with depressive disorders (SR: aOR = 2.43, CI: 1.22-4.74, p = .01; PR: aOR = 2.56, CI: 1.31-5.05, p = .01), the combined presentation of ADHD (SR: aOR = 1.91, CI: 1.14-3.22, p = .01; PR: n.s.), Autism Spectrum Disorder (SR: n.s.; PR: aOR = 2.24, CI: 1.34-3.73, p < .001), greater levels of impairment (SR: Standardized Beta = 4.63, CI: 3.06-6.20, p < .001; PR: Standardized Beta = 5.05, CI: 3.67-6.42, p < .001) and increased sleep disturbances (SR: Standardized Beta = 3.15, CI: 0.71-5.59, p = .01; PR: Standardized Beta = 3.55, CI: 1.34-5.75, p < .001), even when accounting for demographic covariates and psychiatric comorbidity.Conclusions: The association between PIU and psychopathology, as well as its impact on impairment and sleep disturbances, highlight the urgent need to gain an understanding of mechanisms in order to inform public health recommendations on internet use in U.S. youth.
Laparoscopic based renal denervation in a canine neurogenic hypertension model
Authors: Shao Chunlai , Zhou Yan , You Tao , Xue Boxin , Stella Pieter R , Jiang TingBo , Miao Zhigang , Xu Longjiang , Yin Yin , Lan Longsheng , Rong Guang 
Published: April 2020

Abstract
Background: Previous renal denervation (RDN) studies showed controversial results in reducing blood pressure. The aim of this study was to provide evidence supporting the effectiveness of laparoscopic-based renal denervation (L-RDN) in treating hypertension.
Methods: Sixteen Beagle dogs were randomly divided into RDN group (n = 12) and sham group (n = 4). Neurogenic hypertension was generated in all dogs via carotid artery route. L-RDN was performed in the RDN group, with sham operation performed as a control. Blood pressure (BP) changes were recorded at 2, 4, 6, and 8 weeks after the procedure. Changes in serum creatinine (sCr), blood urea nitrogen (BUN) and level of norepinephrine (NE) were analyzed. Histological changes of kidney and renal arteries were also evaluated.
Results: BP and NE levels were significantly elevated after hypertension induction (p < 0.01). Systolic and diastolic BP of RDN group were decreased by 15.5 mmHg and 7.3 mmHg (p < 0.0001 and p = 0.0021, respectively) at the eighth week after L-RDN. Invasive systolic and diastolic BP of RDN group were significantly decreased by 14.5 mmHg and 15.3 mmHg (p < 0.0001). In contrast, there was no significant decrease in blood pressure in the sham group. In addition, RDN group but not the sham group showed a significant decrease in NE levels (p < 0.001), while no significant changes in sCr and BUN were observed in both groups. Pathological examinations showed no discernible damage, tear, or dissection to the renal arteries in RND group.
Conclusions: L-RDN lowered BP and NE levels in hypertensive dogs without affecting renal artery morphology and kidney function.
A practice improvement package at scale to improve management of birth asphyxia in Rwanda: A before-after mixed methods evaluation
Authors: Umunyana Jacqueline , Sayinzoga Felix , Ricca Jim , FAVERO RACHEL , Manariyo Marcel , Kayinamura Assumpta , Tayebwa Edwin , Khadka Neena , Molla Yordanos , Kim Young-Mi 
Published: April 2020

Abstract
Background: Helping Babies Breathe (HBB) is a competency-based educational method for an evidence-based protocol to manage birth asphyxia in low resource settings. HBB has been shown to improve health worker skills and neonatal outcomes, but studies have documented problems with skills retention and little evidence of effectiveness at large scale in routine practice. This study examined the effect of complementing provider training with clinical mentorship and quality improvement as outlined in the second edition HBB materials. This “system-oriented” approach was implemented in all public health facilities (n=172) in ten districts in Rwanda from 2015 to 2018.
Methods: A before-after mixed methods study assessed changes in provider skills and neonatal outcomes related to birth asphyxia. Mentee knowledge and skills were assessed with HBB objective structured clinical exam (OSCE) B pre and post training and during mentorship visits up to one year afterward. The study team extracted health outcome data across the entirety of intervention districts and conducted interviews to gather perspectives of providers and managers on the approach.
Results: Nearly forty percent (n= 772) of health workers in maternity units directly received mentorship. Of the mentees who received two or more visits (n=456), sixty percent demonstrated competence (received > 80% score on OSCE B) on the first mentorship visit, and 100% by the sixth. In a subset of 220 health workers followed for an average of five months after demonstrating competence, 98% maintained or improved their score. Three of the tracked neonatal health outcomes improved across the ten districts and the fourth just missed statistical significance: neonatal admissions due to asphyxia (37% reduction); fresh stillbirths (27% reduction); neonatal deaths due to asphyxia (13% reduction); and death within 30 minutes of birth (19% reduction, p=0.06). Health workers expressed satisfaction with the clinical mentorship approach, noting improvements in confidence, patient flow within the maternity, and data use for decision-making.
Conclusions: Framing management of birth asphyxia within a larger quality improvement approach appears to contribute to success at scale. Clinical mentorship emerged as a critical element. The specific effect of individual components of the approach on provider skills and health outcomes requires further investigation.
Cone beam computed tomographic analysis of the spatial limitation during mandibular arch distalization
Authors: Chen Chia-Ling , Chen Chia-Hui , Pan Chin-Yun , Chang Hong-Po , Chen Ping-Ho , Tseng Yu-Chuan 
Published: April 2020

Abstract
Background: In the literature, attempts are seldom made to quantify spatial limitation during mandibular arch distalization. This study aimed to investigate the spatial limitations associated with cortical contact with the mandibular second molar during mandibular arch distalization.
Methods: The study population included 67 individuals who had undergone cone beam computed tomography (CBCT) (34 male and 33 female; mean age: 23.9 ± 2.72 years). The total ridge width, alveolar housing width, and root width were measured to evaluate the buccolingual limit. The space distal to the molar root represented the mesiodistal limit. The influence of sex, right versus left side, root-contact condition, malocclusion category, and presence of wisdom teeth were evaluated.
Results: The rate of cortical contact was 49.3% before any orthodontic movement. No significant differences were observed in the alveolar width according to sex (male vs female), side assessed (right vs left), wisdom teeth (present vs absent), or malocclusion category. The ridge width and the alveolar width were smaller in the contact group than in the non-contact group ( P < 0.01). The group with wisdom teeth showed a larger available distalization distance, but a significant difference was observed only near the alveolar crest.
Conclusions: Both ridge width and available distalization distance were limiting factors for mandibular teeth distalization. For cases in which whole-arch distalization is planned, CBCT is recommended before treatment, especially for non-extraction treatment. This approach ensures safe and predictable tooth movement.
Amaryllidaceae alkaloids with anti-Trypanosoma cruzi activity
Authors: Martinez-Peinado Nieves , Cortes-Serra Nuria , Torras-Claveria Laura , Pinazo Maria-Jesus , Gascon Joaquim , Bastida Jaume , Alonso-Padilla Julio 
Published: April 2020

Abstract
Background: Chagas disease, caused by the protozoan Trypanosoma cruzi, is a neglected disease that affects ~7 million people worldwide. Development of new drugs to treat the infection remains a priority since those currently available have frequent side effects and limited efficacy at the chronic stage. Natural products provide a pool of diversity structures to lead the chemical synthesis of novel molecules for this purpose. Herein we analyzed the anti- T. cruzi activity of 9 alkaloids derived from plants of the Amaryllidaceae family.
Methods: the activity of each alkaloid was assessed by means of an anti- T. cruzi phenotypic assay. We further evaluated the compounds that inhibited the parasite growth on two distinct cytotoxicity assays to discard those that were toxic to host cells and assure parasite selectivity.
Results: we identified a single compound (hippeastrine 2 ) that was selectively active against the parasite yielding selectivity indexes of 12.7 and 35.2 against Vero and HepG2 cells, respectively. Moreover, it showed specific activity against the amastigote stage (IC 50 = 3.31 μM).
Conclusions: results reported here suggest that natural products are an interesting source of new compounds for the development of drugs against Chagas disease.
Comparative Outcome of Loop Suspensory Reconstruction and Hook Plate Fixation for Acute Type III-V Acromioclavicular Joint Dislocation
Authors: Chang Yu-Jui , Chou Wen-Yi , Ko Jih-Yang , Liu Hao-Chen , Yang Ya-Ju , Siu Ka-Kit 
Published: April 2020

Abstract
Background Treatment options of acromioclavicular (AC) joint dislocation depend on the injury severity and the functional demand of the patient. Common surgical options include fixation across the AC joint, coracoclavicular (CC) fixation, and AC joint or CC reconstruction. However, the clinical superiority of these various procedures is controversial. This study aimed to compare the clinical and radiological outcomes of loop suspensory reconstruction and hook plate fixation for acute unstable AC joint dislocation.Methods We retrospectively included patients with acute unstable AC joint dislocation who were treated with loop suspensory reconstruction (group I, 23 cases) or hook plate fixation (group II, 14 cases) in our hospital from January 2010 to December 2016 with a minimum follow-up period of 1 year after surgery. We assessed the clinical outcomes of blood loss during surgery, surgical duration, duration of medication required for pain relief after the primary operation, occurrence of complications, and the Constant-Murley score; radiological analysis included postoperative arthritic change and the CC distance discrepancy ratio (CCDR) on preoperative and final follow-up plain films.Results The average follow-up duration was17.0±6.1 months. The mean duration of pain-control medication usage was 121.7±174.1 and 235.4±251.8 days in groups I and II, respectively, significantly lower in the CC reconstruction group (p=0.031). Group I revealed a superior Constant-Murley score at the final outpatient follow-up as compared with group II (71.7±15.8 vs 61.1±6.7, p=0.009). Regarding radiographic analysis, the hook plate group had a superior residual CCDR (group I vs II = 30% vs 80±40%, p<0.001). In addition, there were 9 cases of subluxation noted in group I and 2 cases in group II; however, 4 cases of acromion osteolysis were observed in group II.Conclusions The principle finding of the present study was that hook plate fixation was superior to loop suspensory reconstruction in terms of CC distance maintenance. However, the loop suspensory reconstruction group demonstrated superior clinical functional outcomes and less painkiller usage. A further randomized controlled trial with a long-term follow-up period is required.
Chronic Exposure to Ambient Particulate Matter Induces Gut Microbial Dysbiosis in a Rat COPD Model
Authors: Li Naijian , Yang Zhaowei , Liao Baoling , Pan Tianhui , Pu Jinding , Hao Binwei , Fu Zhenli , Cao Weitao , Zhou Yuming , He Fang , Li Bing , Ran Pixin 
Published: April 2020

Abstract
Background The role of the gut microbiota in the pathogenesis of chronic obstructive pulmonary disease following exposure to ambient particulate matter is largely unknown. We hypothesized that exposure alters gut microbial composition and metabolites and is involved in the pathogenesis of chronic obstructive pulmonary disease. Methods Fifty-four male Sprague-Dawley rats were exposed to clean air, biomass fuel, or motor vehicle exhaust for 4, 12, and 24 weeks. Lung tissue was assessed histologically and gut microbial composition was assessed by 16S rRNA pyrosequencing. Serum lipopolysaccharide levels were measured and short-chain fatty acids in colon contents were quantified. Results After a 24-week exposure to particulate matter, rats exhibited pulmonary inflammation and pathological changes characteristic of chronic obstructive pulmonary disease. The gut microbiome was characterized by decreased microbial richness and diversity, distinct overall microbial composition, lower levels of short-chain fatty acids, and higher serum lipopolysaccharide. Conclusion Chronic exposure to ambient particulate matter induces gut microbial dysbiosis and metabolite shifts in a rat model of chronic obstructive pulmonary disease.
Effects of alkaline water intake on gastritis and miRNA expression (miR-7, miR-155, miR-135b and miR-29c)
Authors: Chaves Juliana Ramos , Souza Carolina Rosal Teixeira de , Modesto Antonio André Conde , Moreira Fabiano Cordeiro , Teixeira Eliel Barbosa , Sarraf Jonathan Souza , Allen Thaís Suellen Ramos , Araújo Taíssa Maíra Thomaz , Khayat André Salim 
Published: April 2020

Abstract
Background : It is known that abnormal expression of miRNAs in the gastric cancer (GC) contributes to its carcinogenesis. Therefore, ingestion of commercial (usual) water on a daily basis may be a contributing factor for the occurrence of alterations in the gastric mucosal. In this study, it was evaluated the expression of the miRNAs miR-29c, miR-7, miR-155, and miR-135b in the gastric tissue of patients with gastritis before and after the consumption of alkaline water (pH range from 8.0 to 10.0), as well as the clinic pathological characteristics. Methods : 50 subjects from the Amazon region, diagnosed with gastritis that routinely used commercial (usual) water with a pH lower than 5.0, were enrolled to change the consume water to a pH of 8.5 to 10.0 for 5 months. Results : Endoscopic findings of gastritis were such different (less severe disease), p = 0.024; in 43% diagnosed with moderate gastritis upfront esophagogastroduodenoscopy (EGD) presented mild gastritis after the consumption of alkaline water, according to study methods; there were no worsening gastritis and there were a significant increase in the expression of miR-135b (p = 0.039) and miR-29c (p = 0.039). Conclusions : Modified pH range water (from 8.0 to 10.0) ingested for 5 months was able lead to a less severe gastritis according to the Sidney classification system, suggesting that this lifestyle change represented a clinical benefit in patients with gastritis on the Amazon region. In addition, higher expression of miR-135b and miR-29c was observed after the consumption of alkaline water for 5 months.
The Molecular Pathogenesis of Trichilemmal Carcinoma
Authors: Ha Jeong Hyun , Lee Cheol , Lee Kyu Sang , Pak Chang-sik , Sun Choong-Hyun , Chang Hak , Koh Youngil 
Published: April 2020

Abstract
Background : Trichilemmal carcinoma (TC) is an extremely rare hair follicle tumor. We aimed to explore the genetic abnormalities involved in TC to gain insight into its molecular pathogenesis. Methods : Data from patients diagnosed with TC within a 12-year period were retrospectively reviewed. Genomic DNA isolated from a formalin-fixed paraffin-embedded (FFPE) tumor tissue block was sequenced and explored for a panel of cancer genes. Results : DNA was extracted from the FFPE tissue of four patients (50% female; mean age, 51.5 years) diagnosed with TC for analysis. The tumor was located in the head and neck of three patients and in the shoulder of one patient. TP53 mutations (p.Arg213*, p.Arg249Trp, and p.Arg248Gln) were found in three patients. Fusions previously identified in melanoma were detected in two patients ( TACC3-FGFR3 and ROS1-GOPC fusions). Other mutations found included NF1-truncating mutation (Arg1362*), NRAS mutation (p.Gln61Lys), TOP1 amplification, and PTEN deletion. Overall, genetic changes found in TC resemble that of other skin cancers, suggesting similar pathogenesis. All patients with TP53 mutations had aggressive clinical course, two who died (OS 93 and 36 months), and one who experienced recurrent relapse. Conclusions : We reported the genomic variations found in TC, which may give insight into the molecular pathogenesis. Overall, genetic changes found in TC resembled that of other skin cancers, suggesting similar pathogenesis. TP53 mutations was were identified in patients who had an aggressive clinical course. Genetic alterations identified may further suggest the potential treatment options of TC.