bluuebunny/crossref_metadata_2025_split huggingface dataset:
Método clase invertida y desarrollo de competencias estadísticas en estudiantes de maestría
Authors: Ramón Ortiz Julia Ángela , Vilchez Jesús 
Published: December 2020

El presente artículo trata sobre la gestión de datos en el proceso de investigación a nivel de estudios de maestría como parte de la formación continua del docente, y tuvo como objetivo determinar la efectividad del método Clase Invertida como estrategia didáctica en la mejora de la competencia estadística en estudiantes de maestría en educación, Universidad de Huánuco (Perú). La metodología utilizada fue la cuantitativa, diseño de estudio cuasiexperimental, con una muestra de 47 estudiantes distribuidos en dos grupos (control y experimental), al inicio se administra una prueba previa sobre conocimientos de estadística descriptiva, el proceso experimental se llevó a cabo en los temas: estimación de intervalo de confianza y prueba de hipótesis, durante ocho sesiones de clase en ambos grupos, al final de la intervención se administra la posprueba. Los resultados obtenidos muestran que las competencias previstas y el nivel de satisfacción fueron más significativo en el grupo experimental. En conclusión, el método Clase Invertida es más efectiva que el método tradicional, para el logro de aprendizajes y el desarrollo de competencias estadísticas de los estudiantes de maestría.
e los estudiantes de maestría.
Cantos que aprendemos nos sonhos: os grupos de canto/corais Ava-guarani e a transmissão de saberes através da experiência onírica na aldeia Ocoy/ Paraná.
Authors: Refatti Denize 
Published: December 2020

Este artigo tem como mote principal descrever as relações existentes entre os sonhos e os Ava-guarani, refletindo principalmente sobre como os sonhos estão presentes na transmissão de saberes dos grupos de canto da aldeia indígena Ocoy, em São Miguel do Iguaçu – Paraná. Considero que os sonhos são experiências coletivas que envolvem um conjunto de atividades, e possibilitam o acesso a um plano cosmológico que orienta a vida cotidiana. O artigo aponta para os modos como os cantos dos corais se afinam com a experiência onírica no que se refere aos conteúdos, às iniciações, à execução de instrumentos, entre outras dinâmicas que fazem parte das atividades dos grupos de canto.
Optimization of HDI West Kalimantan with the Education Sector Effectiveness Strategy
Authors: Kurniawati Dedek Kurniawati 
Published: December 2020

Representasi dari hasil pembangunan yang optimal adalah indeks pendidikan yang efektif. Selain itu, ada dua komponen seperti indeks kesehatan dan indeks daya beli yang juga dapat membentuk IPM. Namun, dibandingkan kedua komponen tersebut indeks pendidikan yang relatif paling mempengaruhi IPM khususnya di Kalimantan Barat. Dengan demikian, diharapkan efektivitas pendidikan dapat menjadi solusi untuk mengoptimalkan IPM di Bidang lainnya.

Sesuai dengan program Gubernur Kalimantan Barat yang fokus untuk menyelenggarakan pendidikan gratis sebagai satu di antara dukungan dalam pengoptimalan IPM di Kalimantan Barat. Selain itu, peningkatan partisipasi masyarakat dalam pembangunan pendidikan juga perlu untuk dilaksanakan. Penerapan strategi jitu sebagai solusi untuk mengatasi permasalahan pada bidang pendidikan perlu untuk dilakukan secara optimal. Berdasarkan upaya tersebut diharapkan dapat menjawab berbagai permasalahan yang ada di Kalimantan Barat khususnya terkait IPM di Kalimantan Barat.
PENGARUH DENDA PAJAK KENDARAAN BERMOTOR TERHADAP PERILAKU TAAT PAJAK
Authors: Sabinus Sabinus 
Published: December 2020

Penelitian dilakukan di Kabupaten Bengkayang terhadap wajib pajak kendaraan bermotor. Penelitian dilakukan karena data tunggakan pajak kendaraan bermotor yang cukup besar di Kalimantan Barat yakni sebesar 920 miliar rupiah yang berpengaruh terhadap potensi penerimaan asli daerah Provinsi Kalimantan Barat. Kondisi ini perlu mendapat perhatian seluruh stakeholders agar tidak terus terjadi karena dapat berefek pada berkurangnya pendapatan asli daerah (PAD) Provinsi Kalimantan Barat. Penelitian bertujuan untuk mengetahui upaya pemerintah dalam meningkatkan realisasi pembayaran pajak kendaraan bermotor dan untuk mengetahui sejauh mana denda berpengaruh terhadap perilaku taat pajak. Manfaat penelitian ini untuk memberikan rekomendasi dalam memformulasikan dan mengevaluasi agar terciptanya mas.yarakat taat pajak kendaraan bermotor. Metode penelitian menggunakan metode kuantitatif dengan berdasarkan data tunggakan pajak kendaraan bermotor yang dipublikasikan oleh Badan Pendapatan Daerah Provinsi Kalimantan Barat serta melakukan wawancara dan penyebaran kuisioner secara daring mulai Februari hingga April tahun 2020. Hasil penelitian menunjukkan perlu adanya sanksi administrasi (denda) keterlambatan pembayaran pajak kendaraan bermotor tetapi dikenakan bukan pada tahun berjalan melainkan pada tahun berikutnya serta harus adanya inovasi system pemberitahuan/notifikasi dari samsat/bapenda secara daring kepada wajib pajak bahwa jatuh tempo pajak sudah berkahir dan adanya penagihan secara langsung oleh petugas.
Kata kunci: Pajak Kendaraan Bermotor, Perilaku, Pendapatan Asli Daerah
Recomendações sobre design informacional aplicado em motion graphics
Authors: Fronza André Luiz , Blum Arina , Meürer Mary Vonni 
Published: December 2020

Tendo sua origem no cinema, o motion graphics tornou-se uma linguagem audiovisual bastante difundida a partir dos anos 1990 devido ao avanço tecnológico na área da computação gráfica. É caracterizado por concentrar-se em uma área de criação que permite a combinação e manipulação de ilustrações, elementos gráficos, fotografia e vídeos, num determinado espaço-tempo unido ao uso de música e efeitos sonoros. Neste contexto, o presente artigo relata a pesquisa que objetivou identificar se, para o público jovem, o motion graphicstransmite informações com maior efetividade do que um material estático. Também buscou-se compreender o processo de criação e concepção do motion graphics, tendo o intuito de futuramente formular um guia para os profissionais da área a fim de auxiliá-los no processo de organização visual e cognitiva da mensagem em projetos desse tipo. Para alcance dos objetivos propostos, foi realizada uma pesquisa d e caráter misto, do tipo exploratória, utilizando dados quantitativos obtidos a partir de um questionário fechado aplicado a alunos de Ensino Médio e informações qualitativas provindas de dois focus group com estudantes de Design. Constatou-se que há diferenças na percepção de informações estáticas em comparação às animadas (motion graphics) e que o motion designer, ao projetar uma animação,deve ter primor na aplicação dos princípios básicos que concernem o design da informação.
LA PROTECCIÓN DE LOS DERECHOS FUNDAMENTALES EN EL ESPACIO EUROPEO Y LOS DIVERSOS ESTÁNDARES POSIBLES DE PROTECCIÓN: EL CASO DEL RECONOCIMIENTO DE LA DIMENSIÓN SOCIAL DEL DERECHO A LA VIVIENDA POR PARTE DEL TEDH
Authors: Drigo Caterina 
Published: December 2020

El presente trabajo se propone clarificar los múltiples contornos de los derechos a la vivienda, con una particular referencia a la dimensión regional europea evidenciando los elementos de juicio utilizados por el TEDH. En concreto, la tutela de los derechos a la vivienda sigue diferentes vías, con la combinación de una pluralidad de mecanismos de protección que pueden combinarse de manera variada entre ellos y que son, ante todo, de carácter político, pero que implican también la intervención de medidas de carácter administrativo y jurisdiccional.
“The protection of fundamental rights in Europe and the possible protection standards: Case study on the recognition of the social dimension of housing rights by the ECtHR.”
Abstract
With this work we aim to clarify the multifaceted contours of housing rights, with particular reference to the European context, highlighting the standards of judgment used by the ECHR. In particular, the protection of house rights follows various and articulated paths, making use of the combination of a plurality of protection mechanisms that can variously combine and which are primarily political, but which also impose the intervention of administrative and jurisdictional measures.
Predictors of Long‐Term Outcome of Subthalamic Stimulation in Parkinson Disease
Authors: Cavallieri Francesco , Fraix Valérie , Bove Francesco , Mulas Delia , Tondelli Manuela , Castrioto Anna , Krack Paul , Meoni Sara , Schmitt Emmanuelle , Lhommée Eugénie , Bichon Amélie , Pélissier Pierre , Chevrier Eric , Kistner Andrea , Seigneuret Eric , Chabardès Stephan , Moro Elena 
Published: December 2020

ObjectiveThis study was undertaken to identify preoperative predictive factors of long‐term motor outcome in a large cohort of consecutive Parkinson disease (PD) patients with bilateral subthalamic nucleus deep brain stimulation (STN‐DBS).MethodsAll consecutive PD patients who underwent bilateral STN‐DBS at the Grenoble University Hospital (France) from 1993 to 2015 were evaluated before surgery, at 1 year (short‐term), and in the long term after surgery. All available demographic variables, neuroimaging data, and clinical characteristics were collected. Preoperative predictors of long‐term motor outcome were investigated by performing survival and univariate/multivariate Cox regression analyses. Loss of motor benefit from stimulation in the long term was defined as a reduction of less than 25% in the Movement Disorder Society–sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS‐UPDRS) part III scores compared to the baseline off‐medication scores. As a secondary objective, potential predictors of short‐term motor outcome after STN‐DBS were assessed by performing univariate and multivariate linear regression analyses.ResultsIn the long‐term analyses (mean follow‐up = 8.4 ± 6.26 years, median = 10 years, range = 1–17 years), 138 patients were included. Preoperative higher frontal score and off‐medication MDS‐UPDRS part III scores predicted a better long‐term motor response to stimulation, whereas the presence of vascular changes on neuroimaging predicted a worse motor outcome. In 357 patients with available 1‐year follow‐up, preoperative levodopa response, tremor dominant phenotype, baseline frontal score, and off‐medication MDS‐UPDRS part III scores predicted the short‐term motor outcome.InterpretationFrontal lobe dysfunction, disease severity in the off‐medication condition, and the presence of vascular changes on neuroimaging represent the main preoperative clinical predictors of long‐term motor STN‐DBS effects. ANN NEUROL 2021;89:587–597
Indirect Formic Acid Fuel Cell Based on a Palladium or Palladium‐Alloy Film Separating the Fuel Reaction and Electricity Generation
Authors: Madrid Elena , Harabajiu Catajina , Hill Robyn S. , Black Kate , Torrente‐Murciano Laura , Dickinson Angus J. , Fletcher Philip J. , Ozoemena Kenneth I. , Ipadeola Adewale K. , Oguzie Emeka , Akalezi Chris O. , Marken Frank 
Published: December 2020

AbstractAn indirect fuel cell concept is presented herein, where a palladium‐based membrane (either pure Pd with 25 μm thickness or Pd75Ag25alloy with 10 μm thickness) is used to separate the electrochemical cell compartment from a catalysis compartment. In this system, hydrogen is generated from a hydrogen‐rich molecule, such as formic acid, and selectively permeated through the membrane into the electrochemical compartment where it is then converted into electricity. In this way, hydrogen is generated and converted in situ, overcoming the issues associated with hydrogen storage and presenting chemical hydrogen storage as an attractive and feasible alternative with potential application in future micro‐ and macro‐power devices for a wide range of applications and fuels.
Naphthalimide‐Based Hydrazone Derivatives: Synthesis, Mechanochromism in the Solid State and Response to Ions in Dilute Solutions
Authors: Shi Shuai , Gu Pei‐Yang , Zhou Shiyuan , Zhu Yutao , He Jinghui , Xu Qingfeng , Lu Jianmei 
Published: December 2020

AbstractMolecules showing mechanochromic luminescence (MCL) are promising for use in the in the fields of sensing and probes. We report the design and synthesis of new naphthalimide‐based hydrazone derivatives, NI‐TPE and NI‐3BA. Both the luminogens are weakly emissive with sΦf=0.3 % and 0.5 % respectively when aggregated in amorphous states as strong π‐π stacking and intermolecular interaction prevent luminescence. On the contrary, in the crystalline state, single crystal analysis of two derivatives shows that nonradiative decay is reduced or inhibited by molecular stacking modes and intermolecular interactions. Increases of fluorescence emission intensity to sΦf=5.5 % and 6.0 % upon solvent evaporation are attributed to weak π‐π overlapping and hydrogen bonding (N−H ⋅⋅⋅ O, distance 2.99 Å), which are beneficial to the formation of molecules with a loose packing. At the same time, the packing modes that the two derivatives adopt in the crystal lattice are destroyed to result in a low solid‐state fluorescence quantum yield and a bathochromic shift of 23–25 nm upon grinding. All these factors cause the two derivatives show an unusual “turn off” MCL phenomenon. The fluorescence emission, its pH reversibility, and selective response to fluoride and acetate ions of up to 91–93 % in dilute solutions were also demonstrated.
Knockdown of lactate dehydrogenase by adeno‐associated virus‐delivered CRISPR/Cas9 system alleviates primary hyperoxaluria type 1
Authors: Zheng Rui , Fang Xiaoliang , Chen Xi , Huang Yunteng , Xu Guofeng , He Lei , Li Yueyan , Niu Xuran , Yang Lei , Wang Liren , Li Dali , Geng Hongquan 
Published: December 2020

AbstractBackgroundPrimary hyperoxaluria type 1 (PH1) is a rare genetic disorder caused by endogenous overproduction of hepatic oxalate, leading to hyperoxaluria, recurrent calcium oxalate kidney stones, and end‐stage renal disease. Lactate dehydrogenase (LDH) is an ideal target for diminishing oxalate production as it is responsible for glyoxylate to oxalate conversion in the liver, the last step of oxalate metabolism. Here, we investigated the therapeutic efficacy and potential side effects of clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 technology to ameliorate PH1 via specifically disrupting the hepatic LDH.MethodsPheochromocytoma (PC12) cells were used to assess the efficacy of cleavage of single‐guide RNAs in vitro. PH1 neonatal rats were injected with a single administration of adeno‐associated virus to deliver the CRISPR/Cas9 system that targeted LDH. Three weeks after injection, a liver biopsy was performed to detect LDH expression, liver injury, and liver metabolomics. Urinary oxalate was regularly monitored, and renal calcium oxalate deposition was evaluated after 4 weeks of 0.5% ethylene glycol challenge. After 6 months of treatment, animals were euthanized, and ex‐liver organs were harvested for toxicity analysis.ResultsThe Ldha gene was specifically knocked out in 20% of the liver cells of PH1 rats in the treatment group, leading to a 50% lower LDH expression than that in the control group. Compared to the control groups, urinary oxalate levels were significantly decreased, and renal calcium oxalate precipitation was largely mitigated in the treatment group throughout the entire 6‐month study period. While no CRISPR/Cas9‐associated off‐target edits or hepatotoxicity were detected, we observed mild metabolic changes in the liver tricarboxylic acid (TCA) and glycolysis pathways.ConclusionsCRISPR/Cas9‐mediated LDH disruption may represent an applicable new strategy for alleviating PH1 for its long‐lasting effect and low editorial efficiency requirements.
Influence of surface resistivity of insulation films on penetration phenomenon by negative lightning impulse discharge
Authors: Mizusaki Masayuki , Araoka Nobutaka , Takamura Norimitsu , Sasaki Yuki , Ryu Terumasa , Matsuda Mikiya , Namihira Takao , Hanai Masahiro 
Published: December 2020

AbstractA method is needed to prevent damage of wind power generators from lightning strikes even if lightning strikes the blades. In our experiment, the discharge progressing to the film was hard to penetrate the low surface resistivity polyethylene terephthalate (PET) films with conductive coating on one side, although the discharge always penetrated the uncoated PET film. This result was confirmed when the coated surface of the film was directed to either the high voltage rod electrode side or the ground plate electrode side. It was also confirmed that the progress of negative leader generated from the high voltage rod electrode side was hindered by the film from the photograph with the high speed camera. The time constant was calculated from the product of the surface resistance and the capacitance between the film and the plate electrode. As a result, it was suggested that the propagation of electric potential might be fast because time constant is smaller in the case of the low surface resistivity PET films.
Structural analysis of a compound despite the presence of an isobaric interference by using in‐source Collision Induced Dissociation and tandem mass spectrometry
Authors: Jeanne Dit Fouque Dany , Maroto Alicia , Memboeuf Antony 
Published: December 2020

AbstractThe presence of an isobaric contaminant can drastically affect MS and MS/MS patterns leading to erroneous structural and quantitative analysis, which is a real challenge in mass spectrometry. Herein, we demonstrate that MS and MS/MS structural analysis of a compound can be successfully performed despite the presence of an isobaric interference with as low as few millidaltons mass difference by using pseudo‐MS3. To this end, in‐source collisional excitation (in‐source CID) and the Survival Yield (SY) technique (energy‐resolved collision induced dissociation MS/MS) were performed on two different source geometries: a Z‐spray and an orthogonal spray (with a transfer capillary) ionization sources on two different mass spectrometers. By using soft ionization conditions, the SY curve for the mixture is a linear combination of the SY curves from the pure compounds demonstrating the presence of two components in the mixture. In the case of harsher ionization conditions, the SY curve of the mixture perfectly overlaps the SY curve from the pure analyte. This observation demonstrates the isobaric interference has been completely removed by in‐source CID fragmentation, independently of the source design, leaving then the analyte precursor ions only. Therefore, by measuring the MS spectrum in harsh ionization conditions and according to SY criterium, the compound of interest can be made free from isobaric interference paving the way for, for example, unequivocal HPLC‐MS as well as HPLC‐MS/MS structural and quantitative analysis despite the presence of a co‐eluting isobaric interference.
Portal Vein Complications After Adult Living Donor Liver Transplantation: Time of Onset and Deformity Patterns Affect Long‐Term Outcomes
Authors: Sambommatsu Yuzuru , Shimata Keita , Ibuki Sho , Narita Yasuko , Isono Kaori , Honda Masaki , Irie Tomoaki , Kadohisa Masashi , Kawabata Seiichi , Yamamoto Hidekazu , Sugawara Yasuhiko , Ikeda Osamu , Inomata Yukihiro , Hibi Taizo 
Published: December 2020

Portal vein complications (PVCs) after adult living donor liver transplantation (LDLT) are potentially lethal. We categorized PVCs by the time of onset (early versus late, <1 month versus ≥1 month, respectively) and deformity patterns (portal vein stenosis [PVS], portal vein thrombosis [PVT], and portal vein occlusion [PVO]) to establish optimal treatment strategies. Overall, 35/322 (10.9%) recipients developed PVCs between 2000 and 2019. Pretransplant PVT (odds ratio [OR], 15.20; 95% confidence interval [CI], 3.70‐62.40; P < 0.001) was the only independent risk factor for PVS. In contrast, male sex (OR, 5.57; 95% CI, 1.71‐18.20; P = 0.004), pretransplant PVT (OR, 4.79; 95% CI, 1.64‐14.00; P = 0.004), and splenectomy (OR, 3.24; 95% CI, 1.23‐8.57; P = 0.018) were independent risk factors for PVT. PVS was successfully treated with interventional radiology regardless of its time of onset. On the other hand, late PVT and PVO had significantly lower treatment success rates (2/15, 13%) compared with those that occurred in the early period (10/11, 91%) despite aggressive intervention (P < 0.001). Deformity patterns had a significant impact on the 5‐year cumulative incidence of graft loss as a result of PVC (PVO + Yerdel grades 2‐4 PVT group [n = 16], 41% versus PVS + Yerdel grade 1 PVT group [n = 19], 0%; P = 0.02). In conclusion, late grades 2 to 4 PVT and PVO are refractory to treatment and associated with poor prognoses, whereas PVS has a good prognosis regardless of time of onset. A tailored approach according to the time of onset and deformity patterns of PVC is essential.
Targeted nanomedicines for the treatment of bone disease and regeneration
Authors: Ordikhani Farideh , Zandi Nooshin , Mazaheri Mozhdeh , Luther Gaurav A. , Ghovvati Mahsa , Akbarzadeh Abolfazl , Annabi Nasim 
Published: December 2020

AbstractTargeted delivery by either passive or active targeting of therapeutics to the bone is an attractive treatment for various bone related diseases such as osteoporosis, osteosarcoma, multiple myeloma, and metastatic bone tumors. Engineering novel drug delivery carriers can increase therapeutic efficacy and minimize the risk of side effects. Developmnet of nanocarrier delivery systems is an interesting field of ongoing studies with opportunities to provide more effective therapies. In addition, preclinical nanomedicine research can open new opportunities for preclinical bone‐targeted drug delivery; nevertheless, further research is needed to progress these therapies towards clinical applications. In the present review, the latest advancements in targeting moieties and nanocarrier drug delivery systems for the treatment of bone diseases are summarized. We also review the regeneration capability and effective delivery of nanomedicines for orthopedic applications.