bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immature teratoma arising from uterine corpus in an 11‐year‐old girl: Case report and review of the literature
Authors: Zhao Yinling , Xu Tianhui , Bu Xinhua , Yuan Donglan , Wu Yiqun , Qian Hua 
Published: November 2020

AbstractTeratomas are one of the most common germ cell tumors, and they usually occur in ovaries. Extragonadal teratomas are rare, especially immature ones. Only several cases of primary teratomas of the uterus have been reported since 1929. Here, the case of an 11‐year‐old patient who had a 6‐month history of sustained abnormal vaginal discharge is presented. Transabdominal ultrasonography revealed a solid mass in her uterus, resulting in the patient undergoing surgery. Examination of PET‐CT scans revealed a mass in the right ovary of the patient 20 days after surgery. The patient underwent a second surgery followed by chemotherapy. This is the youngest case among reported patients of primary immature uterine teratoma, and this patient showed no evidence of recurrence during 2 years of follow‐up.
Does visceral adiposity have an effect on the survival outcomes of the patients with endometrial cancer?
Authors: Celik Engin , Kizildag Yirgin Inci , Goksever Celik Hale , Engin Gulgun , Sozen Hamdullah , Ak Naziye , Saip Pınar , Onder Semen , Topuz Samet , Salihoglu Mehmet Y. 
Published: November 2020

AbstractAimEndometrial cancer is the most common cancer of the female reproductive tract in the developed countries. There are many risk factors defined for the development of endometrial cancer, including obesity. We aimed to evaluate the significance of adiposity on the survival outcomes of the patients with endometrial cancer.MethodsThe patients diagnosed with endometrial cancer and underwent surgery between April 2009 and October 2017 were retrospectively reviewed. The visceral adipose tissue and subcutaneous adipose tissue volumes were measured at the level of umbilicus on single‐slice magnetic resonance imaging. Visceral adiposity index was calculated. Patients were compared regarding their clinical, demographical, pathologic and survival characteristics. Patients divided into low visceral adiposity (≤0.265, group 1) and high visceral adiposity (>0.265, group 2).ResultsA total of 186 patients were included in this retrospective study. There was no significant difference in terms of the demographical, clinical and tumor characteristics of the patients, except age, menopausal status, subcutaneous adipose tissue and visceral adipose tissue. Although no significant difference in progression‐free survival and disease‐specific survival was noted between groups (P = 0.181), more patients in group 2 died because of endometrial cancer as statistically significant (P = 0.024). Disease‐specific survival showed a significant difference between groups according to the log‐rank test.ConclusionVisceral adiposity tissue is a significant and reliable prognostic indicator for endometrial cancer prognosis. Women diagnosed with endometrial cancer should be informed about the deleterious effects of visceral adiposity on disease‐specific survival.
Discovery of a Chinese familial deletion 18p syndrome due to a false positive result on noninvasive prenatal testing
Authors: Ju Duan , Zuo Zhigang , Li Xiaozhou , Shi Yunfang , Zhang Ying , Xue Fengxia 
Published: November 2020

AbstractClinical manifestations of deletion 18p syndrome vary a lot, which makes it easily overlooked in the clinical practice. Familial transmission of deletion 18p syndrome is rare. We report a Chinese familial deletion 18p syndrome, which was diagnosed by anatomizing the underlying reason for the discrepancy between noninvasive prenatal testing (NIPT) and prenatal diagnosis. A 35‐year‐old pregnant woman was recruited to our center owing to the abnormal NIPT result with a high risk of chromosome 18 monosomy. However, the karyotype of the fetus was normal after amniocentesis. Further analysis indicated that the pregnant woman herself had an abnormal karyotype of 46,XX,del(18)(p11.2), (arr18p11.32p11.21[136,227‐15,099,116]×1) and her first 12‐year‐old son had got the same deletion of 18p as her. A distinct phenotype variability was noted although they share identical deletion. We consider that adequate clinical genetic counseling is vital for women with adverse pregnancy history before getting pregnant. Maternal CNVs may be one of the main causes of the false‐positive result on NIPT. NIPT, especially extended NIPT may provide extra valuable evidence when used as routine prenatal screening method.
Urothelial health after platelet‐rich plasma injection in intractable recurrent urinary tract infection: Improved cell proliferation, cytoskeleton, and barrier function protein expression
Authors: Jiang Yuan‐Hong , Jhang Jia‐Fong , Hsu Yung‐Hsiang , Ho Han‐Chen , Lin Teng‐Yi , Birder Lori A. , Kuo Hann‐Chorng 
Published: November 2020

AbstractObjectiveThis clinical study used autologous intravesical platelet‐rich plasma (PRP) injections to treat patients with recurrent urinary tract infection (rUTI). Changes in urothelial proliferation, cytoskeleton, and barrier function protein expression after treatment were investigated.MaterialsAll patients underwent 4‐monthly intravesical PRP injections with 1‐year follow‐up. Successful treatment was defined as ≤2 UTI episodes within the preceding 1 year. Bladder biopsies were performed at the first and fourth PRP injection, and specimens were investigated by Western blot for the proteins sonic hedgehog (Shh), CD34, cytokeratin 5 (CK5), CK14, CK20, zonula occludens‐1 (ZO‐1), E‐cadherin, inflammatory proteins tryptase and p38, apoptotic protein BAX (BCL2‐associated X protein) and caspase‐3, functional proteins M2 (muscarinic receptor 2) and M3, and beta‐adrenoceptor‐3, with glyceraldehyde phosphate dehydrogenase used as normalizing protein for quantification.ResultsThe study enrolled 22 patients with rUTI and 17 controls, with successful outcome in 14 of 22 (63.6%) patients. Compared with controls, Western blot quantification results showed that rUTI patients had lower CD34, CK20, M3, and ZO‐1, but higher CK5, BAX, and caspase‐3 at baseline. The reduced CD34, CK20, M2, and M3 expressions at baseline were significantly increased after repeat PRP injections. Patients with a successful outcome had significant increase of CD34, Shh, CK20, M2, and M3 expressions after PRP injections.ConclusionIntravesical PRP repeat injections improve the urothelial cell proliferation and increase the CK 20 expression in umbrella cells. PRP repeat injections have a beneficial effect on bladder urothelium‐associated changes in rUTI. Thus, PRP injection may restore urothelial health and prevent UTI recurrence in intractable rUTI.
Electrolocation? The evidence for redox‐mediated taxis in Shewanella oneidensis
Authors: Starwalt‐Lee Ruth , El‐Naggar Mohamed Y. , Bond Daniel R. , Gralnick Jeffrey A. 
Published: November 2020

AbstractShewanella oneidensis is a dissimilatory metal reducing bacterium and model for extracellular electron transfer (EET), a respiratory mechanism in which electrons are transferred out of the cell. In the last 10 years, migration to insoluble electron acceptors for EET has been shown to be nonrandom and tactic, seemingly in the absence of molecular or energy gradients that typically allow for taxis. As the ability to sense, locate, and respire electrodes has applications in bioelectrochemical technology, a better understanding of taxis in S. oneidensis is needed. While the EET conduits of S. oneidensis have been studied extensively, its taxis pathways and their interplay with EET are not yet understood, making investigation into taxis phenomena nontrivial. Since S. oneidensis is a member of an EET‐encoding clade, the genetic circuitry of taxis to insoluble acceptors may be conserved. We performed a bioinformatic analysis of Shewanella genomes to identify S. oneidensis chemotaxis orthologs conserved in the genus. In addition to the previously reported core chemotaxis gene cluster, we identify several other conserved proteins in the taxis signaling pathway. We present the current evidence for the two proposed models of EET taxis, “electrokinesis” and flavin‐mediated taxis, and highlight key areas in need of further investigation.
Microtubule‐assisted mechanism for toxisome assembly in Fusarium graminearum
Authors: Zhou Zehua , Duan Yabing , Zhang Jie , Lu Fei , Zhu Yuanye , Shim Won Bo , Zhou Mingguo 
Published: November 2020

AbstractIn Fusarium graminearum, a trichothecene biosynthetic complex known as the toxisome forms ovoid and spherical structures in the remodelled endoplasmic reticulum (ER) under mycotoxin‐inducing conditions. Previous studies also demonstrated that disruption of actin and tubulin results in a significant decrease in deoxynivalenol (DON) biosynthesis in F. graminearum. However, the functional association between the toxisome and microtubule components has not been clearly defined. In this study we tested the hypothesis that the microtubule network provides key support for toxisome assembly and thus facilitates DON biosynthesis. Through fluorescent live cell imaging, knockout mutant generation, and protein–protein interaction assays, we determined that two of the four F. graminearum tubulins, α1 and β2 tubulins, are indispensable for DON production. We also showed that these two tubulins are directly associated. When the α1–β2 tubulin heterodimer is disrupted, the metabolic activity of the toxisome is significantly suppressed, which leads to significant DON biosynthesis impairment. Similar phenotypic outcomes were shown when F. graminearum wild type was treated with carbendazim, a fungicide that binds to microtubules and disrupts spindle formation. Based on our results, we propose a model where α1–β2 tubulin heterodimer serves as the scaffold for functional toxisome assembly in F. graminearum.
Cycling amongst Māori: Patterns, influences and opportunities
Authors: Jones Rhys , Kidd Bruce , Wild Kirsty , Woodward Alistair 
Published: November 2020

AbstractThis paper outlines the results of mixed‐methods research on Māori and cycling. Our findings suggest that Māori cycle at similar rates to Pākehā (NZ European); however conditions may differ, possibly indicating higher levels of “necessity cycling” amongst Māori. Māori experience similar barriers to cycling, including a lack of suitable cycling infrastructure, but these occur against a backdrop of stark social, economic and transport‐related inequities. Particular barriers for Māori may include inflexible work conditions, concerns about neighbourhood safety, inadequate provision for social cycling, and lack of access to places of importance to Māori. We identify potential solutions, including more whānau‐friendly and culturally safe cycling infrastructure, and cycling programmes designed around Māori commitments to whanaungatanga and kaitiakitanga.
Palatal rugae positional changes during orthodontic treatment of growing patients
Authors: Pazera Caroline , Gkantidis Nikolaos 
Published: November 2020

AbstractObjectivesTo investigate the anteroposterior and vertical changes of the median rugae area, which is commonly used as dental model superimposition reference, relevant to its underlying skeletal structures.Settings and sample populationRetrospectively collected pre‐ and post‐treatment cephalometric radiographs and 3D digital dental models of 24 orthodontic patients (age at treatment start: 12.26 ± 0.83 years; assessment period: 2.13 ± 0.68 years) were analysed. All had mild to moderate malocclusions that were treated non‐extraction with full fixed appliances.Material and MethodsThe incisive papilla and rugae points were placed on the dental models that were then registered to the cephalometric radiographs. Afterwards, the radiographs were superimposed on Sella, ANS‐PNS, and through a maxillary structural method. The vertical and horizontal movements of the papilla and the rugae points, as well as of a central incisor, were measured (Viewbox 4 software).ResultsThe incisive papilla and the three rugae points remained stable anteroposteriorly, but moved downwards in the vertical dimension (approximately 1‐2 mm), in a similar manner (P > .05). However, the anteroposterior position of the papilla and the first rugae points were affected by changes in anterior tooth position and inclination (P < .05).ConclusionBoth the second and third rugae can be used as superimposition references for tooth movement assessment. The use of the papilla and the first rugae area is not recommended, because they are affected by tooth movement. The outcomes of a palatal superimposition are comparable to those of a maxillary skeletal superimposition in the anteroposterior, but not in the vertical dimension.
Risk Factors of Graft Resorption after Arthroscopic Autologous Scapular Spine Bone Graft for Recurrent Shoulder Instability
Authors: Yang Jinsong , Xiang Ming , Chen Hang , Li Yiping , Zhang Qing , Dai Fei 
Published: November 2020

ObjectiveTo analyze if general factors such as age, gender, dominant side, fasting blood sugar level, BMI (body mass index), smoking, and drinking play a role in graft resorption after arthroscopic autologous scapular spine bone grafting.MethodsFrom July 2016 to August 2018, patients who were diagnosed with anterior shoulder instability with subcritical bone loss (10%–15%) and underwent arthroscopic autologous scapular spine bone graft transplant were retrospectively reviewed and enrolled in this study. The age, gender, dominant side, fasting blood sugar level, BMI, smoking, and drinking conditions of the enrolled patients were recorded. The graft resorption rate at postoperative 1 year was also measured on three‐dimensional computed tomography (3D‐CT) scans. The Pearson test and the Spearman test were used to identify any significant correlation between the general factors and graft resorption rate.ResultsA total of 27 patients who underwent arthroscopic autologous scapular spine bone graft for recurrent shoulder instability qualified and were included in this study. There were 20 males and seven females, the mean age was 30.8 ± 9.4 years, the mean follow‐up time was 29.3 months (range, 25–39 months), during which no severe complications such as infection, neurovascular injury, or re‐dislocation were observed. The bone graft healed in all cases, the mean healing time was 2.6 ± 0.5 months (range, 2–3 months). At the last follow‐up, the mean Constant–Murley score was 89.74 ± 3.71, the mean Disabilities of Arm, Shoulder and Hand (DASH) score was 9.77 ± 5.31, and the mean visual analogue score (VAS) was 0.74 ± 0.64. The apprehension test was all negative at final follow‐up. The fasting blood sugar level was 4.78 ± 0.42 mmol/L, BMI was 23.70 ± 4.70. Five patients were “smoking” and 22 “non‐smoking”, four patients were “drinking” and 23 were “non‐drinking.” The graft resorption rate at postoperative 1 year was 19.4% ± 7.5%. The Pearson test and the Spearman test showed no significant correlation between age, gender, dominant side, fasting blood sugar level, BMI, smoking, drinking, and graft resorption rate.ConclusionAge, gender, dominant side, fasting blood sugar level, BMI, smoking, and drinking were not significantly correlated with graft resorption after the arthroscopic autologous scapular spine bone graft for recurrent shoulder instability.
Barriers and Adherence to Pain Management in Advanced Cancer Patients
Authors: Mercadante Sebastiano , Adile Claudio , Tirelli Walter , Ferrera Patrizia , Penco Italo , Casuccio Alessandra 
Published: November 2020

AbstractAimTo assess patients’ barriers to pain management and analgesic medication adherence in patients with advanced cancer.MethodsThis was a prospective cross‐sectional study in patients with advanced cancer receiving chronic opioid therapy. Age, gender, cancer diagnosis, Karnofsky level, and educational status were recorded. The Brief Pain Inventory (BPI), Edmonton Symptom Assessment Scale (ESAS), Memorial Delirium Assessment Scale (MDAS), Barriers Questionnaire II (BQ‐II), Medication Adherence Rating Scale (MARS), and Hospital Anxiety and Depression Scale (HADS) were the measurement instruments used.ResultsOne‐hundred‐thirteen patients were analyzed. The mean age was 68 (±13) years, and 59 (52%) were male. The mean Karnofsky status was 51.4 (standard deviation [SD] 11.5). The mean score for BQ‐II items was 1.77 (SD 0.7). The BQ‐II score was independently related to the HADS‐Depression score (P = 0.033) and the total HADS score (P = 0.049). Negative side‐effects and attitudes toward psychotropic medication globally prevailed among MARS items. These items were independently associated with gender (P = 0.030), pain (P = 0.003), and depression (P = 0.047).ConclusionBarriers to pain management were mild. Psychological factors such as depression were the main factor associated with barriers. Poor adherence to analgesic medication was mostly manifested as negative side‐effects and attitudes toward psychotropic medication, was more frequent observed in females, and was associated with the ESAS items pain and depression.
Is the estimated glomerular filtration rate formula useful for evaluating the renal function of Down syndrome?
Authors: Nishino Tomohiko , Endo Shota , Miyano Hiroki , Umeda Chisato , Tomii Yuji , Watanabe Yoshitaka , Nakagawa Mayu , Kakegawa Daisuke , Fujinaga Shuichiro 
Published: November 2020

AbstractBackgroundChildren with Down syndrome (DS) have different growth rates compared with normal children. The present study examined the reliability of a general formula, Uemura’s formula, utilized in normal Japanese children to estimate renal function (estimated glomerular filtration rate – eGFR) in children with DS.MethodsThis study included 758 children aged 2–18 years with DS who visited our medical center. Patients with congenital heart disease, or congenital anomalies of the kidney or urinary tract detected via abdominal ultrasonography, chronic glomerulonephritis, and vesicoureteral reflux, etc., were excluded. Height and serum creatinine data gathered from 2421 examinations of 379 children with DS (224 boys and 155 girls) were used to evaluate Uemura’s formula.ResultsThe mean eGFR was lower in children with DS than in children without DS. Stage II chronic kidney disease was indicated in 44.6% of examinations and stage III in 0.8%. The association of eGFR with age differed between sexes. Boys with DS showed a significant but weak negative correlation between eGFR and age (r = −0.273, P < 0.001), whereas girls with DS showed a significant but very weak negative correlation (r = −0.111, P < 0.001).ConclusionsA new eGFR formula that takes into account specific growth rates and puberty is needed for children with DS because general renal function evaluation formulas are inappropriate for these patients.
Academic practice partnerships: A review of a statewide population health nursing leadership initiative
Authors: Jones Krista , Burnett Glenda , Sztuba Laura , Hannon Robin 
Published: November 2020

AbstractObjectiveIn 2012, the state public health nurse (PHN) Leaders Workgroup formed with members from the state PHN Administrators organization and PHN faculty to facilitate the development of statewide PHN Academic practice partnerships (APP's). In 2016, the workgroup received a state Nurses Foundation grant for $6,000 followed by $5,000 in 2017 to fund the first 2 years of APP projects.DesignThe workgroup disseminated two calls for proposals to the Deans of state academic nursing institutions and local health department leaders, utilizing an application adapted from the American Association of Colleges of Nursing (AACN) APP Toolkit. Selection criteria included project intent; partner support; anticipated outcomes; budget; geographic location; and alignment with the Robert Wood Johnson Foundation (RWJF) Culture of Health framework.Sample and ResultsSixteen proposals were received and reviewed by workgroup members resulting in 10 funded pilot projects. In 2018, the workgroup was awarded $55,980 from the RWJF to expand this initiative; funding an additional 10 APP's to date. Partnerships were reported as valuable by students, faculty, and practice partners. Barriers included provider participation, adherence to project timelines, communication, and the navigation of group dynamics.ConclusionAcademic practice partnerships positively impact patient outcomes, patient satisfaction, nursing outcomes, and student learners.
Evaluation of two academic practice partnerships for chronic disease management in nursing education
Authors: McClure Natasha , Lutenbacher Melanie , Smith Hayes K. Melissa 
Published: November 2020

AbstractMore clinical sites are essential to meeting the learning needs of nursing students who will care for patients with chronic disease after graduation. Partnerships between schools of nursing and academic practices can increase clinical training capacity, allow future nurse practitioners (NPs) to apply knowledge and skills in the context of care delivery, and potentially improve patient outcomes with little associated risk. This article describes the experiences of primary care NP students (n = 37), NP faculty (n = 2), and clinic providers (n = 2) in an academic practice partnership performing home visits with complex pediatric asthma and adult heart failure (HF) patients. A 14‐item postexperience survey was used to obtain student feedback. Over 75% (n = 28) of student participants responded. Most respondents, 80% assigned to pediatric asthma patients and 90% assigned to adult HF patients, reported the home visit experience prepared them to care for patients with chronic diseases. Clinic providers indicated the extra attention to both patient groups reduced barriers to care and improved care continuity. This partnership offers a model for developing clinical skills in advanced practice nursing students and enhancing scarce clinical placement resources. Findings were used to refine the program and expand to include all 150 students in the subsequent academic year.
The Fluid Intake Appraisal Inventory for low fluid intake among patients on haemodialysis: Translation and psychometric evaluation of the Danish version
Authors: Pahus Jytte , Lindberg Magnus , Finderup Jeanette , Ludvigsen Mette Spliid 
Published: November 2020

Aims and objectivesTo translate and evaluate the psychometric properties of a Danish version of the Fluid Intake Appraisal Inventory (Da‐FIAI) regarding reliability and validity.BackgroundPatients on haemodialysis are advised to restrict their fluid intake, which often requires patients to change their way of life and health behaviour.DesignCross‐sectional study.MethodsThe FIAI was translated to Danish by two sets of target translations and two sets of back‐translations (n = 4). One hundred and ninety‐five patients on haemodialysis needing ultrafiltration completed the questionnaire for the evaluation study of the Da‐FIAI, and psychometric properties were evaluated.ResultsCriterion validity was supported, and the Da‐FIAI had an excellent internal consistency; known‐groups validity and the factor structure could not be confirmed in the Danish sample.ConclusionsWe have shown that the Da‐FIAI is useful in a Danish haemodialysis population to score the patient’s ability to avoid drinking in specific situations.Relevance to clinical practiceUsing the Da‐FIAI in the continuing nurse–patient communication, nurses have a validated instrument to evaluate patients’ self‐efficacy in fluid intake management and systematically identify and advise patients who need additional support.