bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants and consequences of environmental, social and governance controversies. Status quo and limitations of recent empirical quantitative research
Authors: Bel‐Oms Inmaculada 
Published: December 2024

AbstractThe environmental, social and governance (ESG) controversies, defined as a bad behavior which calling into question the commitment to the firm under the media and capture the attention of investors causing conflicts with sustainable business practices, has received increasing attention from academics of several fields. A literature review methodology is used to reviews articles selected from the Scopus and Web of Science databases from 2018 to 2024. Using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines and the bibliometric techniques, with the goal of mapping the intellectual landscape of the field and indicating the key issues shaping its current development. This paper is to conduct quantitative bibliometric analysis with several research factors, such as authors, citations, journals, countries, and regions, using techniques with improve the visualization of bibliometric analysis. Furthermore, this review provides a conceptual framework of the ESG controversies to obtain their drivers and reveal the consequences companies face after ESG controversies. This manuscript concludes by discussing implications of the literature analysis and providing some opportunities for future research. This research provides to the understanding of the ESG controversies context and shows insights for future lines of research.
Financial sustainability in the context of ESG disclosure: A comprehensive analysis of Chinese‐listed firms
Authors: Hossain Muhammad Istiaque , Qi Baolei , Marie Mohamed , Omran Mohamed , Chen Yucheng 
Published: December 2024

AbstractThis study examines the pivotal role of environmental, social and governance (ESG) disclosure in the financial sustainability of Chinese‐listed companies, addressing a significant gap in the literature regarding the impact of corporate governance mechanisms on this relationship. Utilising a comprehensive dataset spanning from 2009 to 2021, the findings indicate that while ESG disclosure generally enhances financial sustainability, the quality of audits and the independence of boards significantly weaken this relationship by increasing transparency and mitigating managerial opportunism. The robustness of these results has been confirmed through rigorous testing. The study underscores the importance of integrating corporate governance mechanisms into firms' ESG disclosure strategies, aligning with stakeholder theory to optimise financial sustainability. This research provides theoretical and practical contributions by deepening the understanding of governance factors in ESG reporting and their strategic influence on long‐term corporate financial health.
Investigation of left ventricular ejection fraction in a Swiss heart failure population: Insights into mortality and sex differences
Authors: Fuentes Artiles Rubén , Meçani Renald , Muka Taulant , Hunziker Lukas , Capék Lukas 
Published: December 2024

AbstractAimsUnderstanding heart failure (HF) characteristics is essential to improve patient outcomes. Categorizing HF beyond left ventricular ejection fraction (LVEF) is challenging due to heterogeneous clinical presentation and aetiologies. Despite global studies on HF, the role of LVEF on mortality remains controversial. We explored the association of LVEF with mortality, considering sex differences and comorbidities in a cohort from the largest tertiary cardiovascular centre in Switzerland.MethodsHF patients admitted to the University Hospital of Bern from January 2015 to December 2019 were evaluated. LVEF was used to classify patients into HF with preserved ejection fraction (HFpEF), HF with mid‐range ejection fraction (HFmrEF) and HF with reduced preserved ejection fraction (HFrEF) categories. Cox proportional hazard models and time‐stratified analyses adjusted for potential confounders were employed.ResultsA total of 5824 HF patients were included, and 2912 died over a median follow‐up time of 3.39 years. Mortality rates across LVEF categories showed no significant differences, while overall, women showed significantly higher mortality; 30 day mortality was lower in the HFpEF category [hazard ratio (HR) 0.67, 95% confidence interval (CI): 0.52–0.88, P = 0.003], with persistent effects upon stratification in males (HR 0.59, 95% CI: 0.42–0.81, P < 0.001) and non‐diabetics (HR 0.62, 95% CI: 0.44–0.87, P = 0.005). An isolated reduction in HFpEF mortality was observed in females after 1 year (HR 0.72, 95% CI: 0.53–0.98, P = 0.035).ConclusionsThe prognostic role of LVEF on all‐cause mortality remains unclear, while differences in mortality rate distribution between women and men mirror established HF pathophysiological sex differences. Future HF studies should focus on HF aetiology and include measures beyond LVEF for comprehensive characterization.
Physical Similarity Simulation of Closely Stacked Coal Seams Mined in Faulted Geological Environments: A Comprehensive Experimental Investigation
Authors: Zhao Yapeng , Kong Liang , Hu Gaowei , Zhang Peisen , Ji Yunkai 
Published: December 2024

ABSTRACTThe mining of closely stacked coal seams can be associated with complex stress fields, which makes mining difficult. In addition, closely stacked coal seams often coexist with faults and confined aquifers, further complicating mining activities. However, the study of closely stacked coal seams under complex geological conditions with faults (confined water) is very rare. In this study, an experimental approach was adopted to investigate the stress field and displacement field in rocks associated with closely stacked coal mining activity (complex geological conditions with faults and confined water). The materials used in the laboratory had similar physical properties to those present in the mining environment. The results showed that the overlying rock structure has three structural types and three caving forms. When the lower coal seam is mined, the collapse of the overlying strata is characterized by “caving with digging,” “no obvious periodic pressure step,” and “it is difficult to form a beam structure.” Faults function as a stress barrier, which makes it difficult for abutment pressure to cross a fault zone and form a stress concentration near the fault zone. When mining in faulted strata with confined water, there are three areas prone to water inrush, namely near the intersection with the fault zone and coal pillar, the boundary between the coal pillar and goaf, and the middle of the goaf. The research results are of great significance to the mining of closely stacked coal seams under complex geological conditions.
High‐risk cytogenetic abnormalities in multiple myeloma: PETHEMA‐GEM experience
Authors: González‐Calle Veronica , Rodriguez‐Otero Paula , Calasanz Maria J. , Guijarro Manuela , Martínez‐López Joaquin , Rosiñol Laura , Hernández Miguel T. , Teruel Ana I. , Gironella Mercedes , Oriol Albert , de la Rubia Javier , González‐Rodríguez Ana P. , Bargay Joan , de Arriba Felipe , Palomera Luis , González‐Pérez Marta‐Sonia , Sureda Anna , Ocio Enrique , Lahuerta Juan J. , Bladé Joan , San Miguel Jesus F. , Mateos Maria V. , Gutiérrez Norma C. 
Published: December 2024

AbstractThis study examines the impact of cytogenetic abnormalities and their co‐segregation on the prognosis of newly diagnosed multiple myeloma patients. The analysis included 1304 patients from four different GEM‐PETHEMA clinical trials. Genetic alterations, such as t(4;14), t(14;16), del(17p), +1q, and del(1p), were investigated using FISH on CD38 purified plasma cells. The frequency of genetic alterations detected were as follows: del(17p) in 8%, t(4;14) in 12%, t(14;16) in 3%, +1q in 43%, and del(1p) in 8%. The median follow‐up was 61 months, and the median progression‐free survival (PFS) and overall survival (OS) were 44 months and not reached, respectively. Consistent with previous reports, the presence of t(4;14) was associated with shorter PFS and OS. In our series, the presence of t(14;16) did not impact survival, maybe due to limitations in sample size. Del(17p) was linked to poor prognosis using a cut‐off level of ≥20% positive cells, without any impact of higher cut‐off in prognosis, except for patients with clonal fraction ≥80% who had a dismal outcome. Cosegregation of cytogenetic abnormalities patients worsened the prognosis in t(4;14) patients but not in patients with del(17p), which retained its adverse prognosis even as a solitary abnormality. Gain(1q) was associated with significantly shorter PFS and OS, while del(1p) affected PFS but not OS. Nevertheless, when co‐segregation was eliminated, the detrimental effect of +1q or del(1p) was no longer observed. In conclusion, this study confirms the prognostic significance of high‐risk cytogenetic abnormalities in MM and highlights the importance of considering co‐occurrence for accurate prognosis assessment.
IL‐17A Mediates Depressive‐Like Symptoms by Inducing Microglia Activation in Psoriasiform Dermatitis Mice
Authors: Dou Yue , You Jingjing , Wang Jing , Li Xinxin , Lin Yawen , Liu Bin , Ma Lei 
Published: December 2024

ABSTRACTBackgroundPsoriasis is recognized as a systemic disease for its accompanying comorbidities, among which psychological disorders present a high incidence rate and affect patients’ life quality. Interleukin (IL)‐17A is the central pathological factor in the pathogenesis and development of psoriasis.ObjectiveTo clarify if psoriasis‐induced systemic IL‐17A increase can mediate the neuronal inflammation and result in depressive‐like symptoms.MethodsPsoriasiform dermatitis model was established by imiquimod (IMQ) application on male BALB/c mice and IL‐17A intervention was performed by lateral ventricular catheterization. Skin structural, histopathological characteristics, and behavioral tests were assessed. Serum IL‐17A levels were detected by Enzyme‐linked immunosorbent assay. mRNA expression of pro‐inflammatory factors IL‐1β, IL‐6, and tumor necrosis factor‐α (TNF‐α) as well as anti‐inflammatory factors IL‐4 and IL‐10 in the hippocampus and cortex were measured by RT‐qPCR. The number of microglia and hippocampal neurons was quantified by immunofluorescent assay.ResultsIMQ treatment resulted in significant skin structural and histopathological characters of psoriasiform dermatitis with elevated serum IL‐17A levels, obvious depressive‐like behaviors, microglia activation with increased IL‐1β, IL‐6, and TNF‐α expression levels in the hippocampus and cortex, and notable inhibition of hippocampal neurogenesis. While, IL‐17A neutralization by intracerebroventricular injection of anti‐IL‐17A antibody can remarkably inhibit microglia activation and decrease the abnormally increased expression levels of IL‐1β, IL‐6, and TNF‐α in the hippocampus and cortex of psoriasiform dermatitis mice, promote hippocampal neurogenesis, thus alleviate the depressive‐like behaviors.ConclusionIn the pathological condition of psoriasis, systemic IL‐17A elevation can trigger microglia activation, provoke pro‐inflammation mediators to release, evoke neuroinflammation, subsequently inhibit hippocampal neurogenesis, and result in depression. IL‐17A, as an important pathogenic factor in psoriasis, contributes to its critical role in mediating systemic inflammation and depression comorbidity.
Establishment of an Early Prediction Model for Severe Fever With Thrombocytopenia Syndrome‐Associated Encephalitis
Authors: Liu Yijiang , Zhu Naisheng , Qin Zimeng , He Chenzhe , Li Jiaqi , Zhang Hongbo , Cao Ke , Yu Wenkui 
Published: December 2024

ABSTRACTBackgroundSevere fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease primarily transmitted by ticks. The development of encephalitis in SFTS patients significantly increases the risk of adverse outcomes. However, the understanding of SFTS‐associated encephalitis (SFTSAE) is still limited. This study aimed to identify the clinical characteristics of SFTSAE and develop a predictive model for early detection.MethodsWe retrospectively collected data from 220 SFTS patients admitted to Nanjing Drum Tower Hospital between May 2019 and January 2024. The patients were first randomly divided into a training set (154 people, 70%) and a validation set (66 people, 30%). The patients in the training set were divided into SFTSAE and non‐SFTSAE groups according to the presence of encephalitis. A prediction model was constructed using the training set: important clinical parameters were selected using univariate logistic regression, and then multivariate logistic regression was performed to determine the independent risk factors for SFTSAE. A prediction model was constructed using these independent risk factors. Finally, the validation set was used to verify the predictive ability of the model.ResultsAge, C‐reactive protein, d‐dimer, and viral load were independent risk factors for SFTSAE (p < 0.05). A nomogram containing these four indicators was constructed, and the predictive performance of the nomogram was evaluated using the ROC curve. The AUC of the model was 0.846 (95% confidence interval [CI]: 0.770–0.921), which had good predictive ability for SFTSAE.ConclusionConclusion: The overall mortality rate of SFTS patients was 17.53%, and the mortality rate of encephalitis patients was 50%. Old age, high C‐reactive protein, elevated d‐dimer, and high viral load were independent risk factors for SFTSAE. The nomogram constructed based on these four indicators had good predictive ability and could be used as an evaluation tool for clinical treatment.
The Joint Effect of Renal Function Status and Coagulation Biomarkers on In‐Hospital Outcomes in Acute Ischemic Stroke Patients With Intravenous Thrombolysis
Authors: Lu Manli , Xue Junwen , Wang Yi , Chen Dongqin , Cao Yongjun , Zhong Chongke , Zhang Xia 
Published: December 2024

ABSTRACTObjectiveTo demonstrate whether combining renal function status [estimating glomerular filtration rate (eGFR)] with coagulation biomarkers [fibrinogen (Fg) and d‐dimer] is more beneficial in predicting in‐hospital outcomes following intravenous thrombolysis (IVT) in acute ischemic stroke (AIS) patients.MethodsWe studied 417 AIS patients with IVT. According to the cut‐offs of coagulation biomarkers (Fg and d‐dimer) and eGFR determined by receiver operating characteristic (ROC) curves, the patients were divided into four groups: LFLG (low Fg and low eGFR), LFHG (low Fg and high eGFR), HFLG (high Fg and low eGFR), and HFHG (high Fg and high eGFR); or LDLG (low d‐dimer and low eGFR), LDHG (low d‐dimer and high eGFR), HDLG (high d‐dimer and low eGFR), and HDHG (high d‐dimer and high eGFR). Logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for poor outcomes at discharge and post‐stroke pneumonia across the four groups.ResultsThe patients in the HFLG and HDLG groups had the poorest prognosis at discharge and the highest risk of in‐hospital pneumonia. They experienced 3.00 or 4.59 times higher risk of in‐hospital pneumonia than those in the LFHG and LDHG groups (95%CI: 1.07–8.44, p < 0.05; 95%CI: 1.58–13.32, p = 0.005). Similarly, the risk of adverse outcome at discharge was 3.02 and 1.52 times higher in HFLG and HDLG groups (95%CI: 1.63–9.91, p < 0.005; 95%CI: 1.11–5.74, p < 0.05) compared to that in LFHG and LDHG groups. Adding eGFR and Fg or d‐dimer to the risk model improved the risk reclassification for in‐hospital pneumonia and functional outcomes at discharge.ConclusionCombining renal function status and coagulation biomarkers within 4.5 h after onset could better predict in‐hospital outcomes of AIS patients with IVT.
Pollination research in India: Current status, future vision and conservation implications
Authors: Adit Arjun , Singh Vineet Kumar , Tandon Rajesh , Shivanna Kundaranahalli Ramalingaiah 
Published: December 2024

AbstractPollination is a dynamic ecological interaction, that has evolved to promote the survival and reproductive success of flowering plants and their pollinators. Human‐induced environmental changes in recent decades have reduced the density and diversity of pollinators and have resulted in a global pollinator crisis. Western countries have realized this problem since the beginning of this century and extensive research has been going on to study pollinators and pollination in both wild and crop species. To mitigate the crisis, considerable success has been achieved in these countries. In India, investigations on plant‐pollinator interaction, as well as global pollinator‐crisis have received very little attention in spite of its rich biodiversity. So far, the contribution from the Indian region towards pollination biology is merely 5% of the world. This review summarizes limited data available on pollination ecology, analyses possible reasons for this situation, highlights the importance of initiating serious studies on pollinators and pollination and provides a roadmap. It is concluded that a collaborative initiative involving the scientific community, society and policymakers is a prerequisite to achieve the objectives of biodiversity conservation and crop productivity in the country.
Proximal tibial anatomical axis and anterior tibial cortex‐based measurements of posterior tibial slope on lateral radiographs differ least from actual posterior tibial slope—A biomechanical study
Authors: Peez Christian , Waider Caroline , Deichsel Adrian , Briese Thorben , Palma Kries Lucas K. , Herbst Elmar , Raschke Michael J. , Kittl Christoph 
Published: December 2024

AbstractPurposeTo compare different measurement techniques of the posterior tibial slope (PTS) on lateral radiographs with the actual in situ PTS and evaluate the effect of tibial malrotation and image section length.MethodsActual PTS was measured on eight fresh‐frozen tibiae using a portable 6‐axis measuring arm with an accuracy of ±0.01°. True lateral radiographs were taken in the neutral position and after applying 10/20/30° internal/external rotation (IR/ER) and 5/10/15° varus/valgus rotation. The PTS was measured radiographically using five different reference axes: anterior tibial cortex (ATC), anatomical tibial axis, proximal tibial anatomical axis (PTAA), posterior tibial cortex (PTC) and fibular shaft axis (FSA).ResultsThe ATC and PTAA methods showed the lowest deviation from the actual PTS, while the PTC method showed the highest difference of 5.5 ± 1.5° (medial) and 7.1 ± 1.8° (lateral) among all tested methods (p < .001). The PTAA technique showed a 1.9 ± 1.4° (medial) and 2.9 ± 1.8° (lateral) difference from the actual slope (n.s.). ER caused the PTS to increase 0.7 ± 2.0° (10° ER, n.s.) to 3.4 ± 2.1° (30° ER, p < .05), whereas IR caused the PTS to decrease 1.6 ± 1.3° (n.s) to 4.1 ± 1.7° (p < .05) when comparing to the PTAA method for the neutral position. Varus and valgus rotation showed the highest deviation from the neutral rotation at 15° valgus (3.1 ± 2.1°, n.s.).ConclusionTibial slope measurements have a high degree of variability between different measurement methods, while the ATC and PTAA methods showed the least deviation from the actual PTS measured in this in vitro model. Malrotation resulted in a severe distortion of the PTS values, which may alter preoperative planning and intraoperative results. Therefore, radiographic PTS measurements may be contrasted with more objective, reproducible and reliable measuring methods.Level of EvidenceThere is no level of evidence as this study was an experimental laboratory study.
Seasonal mRNA Expression of Circadian Clock Genes in the Lizard Brain
Authors: Grossen Taylor L. , Bunnam Alexus , Cohen Rachel E. 
Published: December 2024

ABSTRACTSeasonally breeding animals undergo physiological and behavioral changes to time reproduction to occur during specific seasons. These changes are regulated by changing environmental conditions, which may be communicated to the brain using the central circadian clock. This clock consists of a daily oscillation in the expression of several core genes, including period (per), cryptochrome (cry), circadian locomotor output cycles kaput (clock), and basic helix‐loop‐helix ARNT‐like protein 1 (bmal1). We began to examine seasonal regulation of four core circadian clock genes in a dissection of the reptile brain containing the hypothalamus—per1, cry1, bmal1 and clock. Our study focused on examining mRNA expression in the morning and compared levels between breeding and nonbreeding animals. We found that per1 and bmal1 mRNA expression was highest in the nonbreeding compared to breeding season in the anole hypothalamus. We also found that cry1 mRNA expression was higher in the female compared to the male anole hypothalamus. We found support for the idea that core circadian genes play a role in regulating changes between the seasons and/or sexes, although more work is needed to elucidate what processes might be differentially regulated. To our knowledge, this is the first examination of the expression of these four genes in the reptilian brain.
Defining Renal Recovery in Patients With Hepatorenal Syndrome‐Acute Kidney Injury: Experience From North American Studies
Authors: Mujtaba Muhammad A. , Elsiesy Hussien , Faiz Sara , Hussain Syed A. , Gamilla‐Crudo Ann Kathleen N. , Karim Aftab , Khan Mohammad Irfan , Khattak Muhammad Waqar , Zafar Zunaira , Kueht Michael , Jamil Khurram 
Published: December 2024

ABSTRACTIntroductionThe degree of improvement in serum creatinine (SCr) has previously been suggested as a sensitive indicator of treatment response in patients with hepatorenal syndrome‐acute kidney injury (HRS‐AKI), while HRS reversal remains the primary endpoint in clinical trials.MethodsA total of ≥ 30% SCr improvement was analyzed as an exploratory prespecified endpoint in the CONFIRM trial. In this post hoc analysis, intent‐to‐treat population data from three Phase 3 studies (OT‐0401, REVERSE, and CONFIRM) conducted in North America in patients with HRS‐AKI were pooled to assess the incidence of > 30% improvement in SCr and its association with clinical outcomes.ResultsSignificantly more patients treated with terlipressin achieved > 30% improvement in SCr compared with those who received a placebo (42.9% vs. 23.4%; p < 0.001). Compared with patients who did not achieve > 30% improvement in SCr, those who achieved this threshold had a lower incidence of renal replacement therapy (RRT) (55.2% vs. 14%, respectively; p < 0.001) and greater overall survival at Day 90 (41.6% vs. 71.1%, respectively; p < 0.001); a greater proportion achieved durability of HRS reversal (1% [95% confidence interval, 95% CI: 0] vs. 68.9% [95% CI: 0.6, 0.8]) and more patients were alive without RRT (22.7% vs. 61.6%, respectively; p < 0.001) or transplant (11.6% vs. 43.0%, respectively; p < 0.0001). Additionally, the overall survival and RRT‐free survival in the group that achieved > 30% improvement in SCr without HRS reversal were comparable to the overall group that achieved HRS reversal.ConclusionA total of > 30% improvement in SCr levels even without HRS reversal may serve as a clinically meaningful endpoint to define renal recovery in patients with HRS‐AKI.