bluuebunny/crossref_metadata_2025_split huggingface dataset:
RAB11FIP5-Deficient Mice Exhibit Cytokine-Related Transcriptomic Signatures
Authors: Li Dapeng , Bradley Todd , Cain Derek W , Pedroza-Pacheco Isabela , Aggelakopoulou Maria , Parks Robert , Barr Maggie , Xia Shi-Mao , Scearce Richard , Bowman Cindy , Stevens Grace , Newman Amanda , Hora Bhavna , Chen Yue , Riebe Kristina , Wang Yunfei , Sempowski Gregory , Saunders Kevin O , Borrow Persephone , Haynes Barton F 
Published: November 2020

Abstract
Rab11 recycling endosomes are involved in immunological synaptic functions, but the roles of Rab11 family–interacting protein 5 (Rab11Fip5), one of the Rab11 effectors, in the immune system remain obscure. Our previous study demonstrated that RAB11FIP5 transcripts are significantly elevated in PBMCs from HIV-1–infected individuals, making broadly HIV-1–neutralizing Abs compared with those without broadly neutralizing Abs; however, the role of Rab11FiP5 in immune functions remains unclear. In this study, a RAB11FIP5 gene knockout (RAB11FIP5−/−) mouse model was employed to study the role of Rab11Fip5 in immune responses. RAB11FIP5−/− mice exhibited no perturbation in lymphoid tissue cell subsets, and Rab11Fip5 was not required for serum Ab induction following HIV-1 envelope immunization, Ab transcytosis to mucosal sites, or survival after influenza challenge. However, differences were observed in multiple transcripts, including cytokine genes, in lymphocyte subsets from envelope-immunized RAB11FIP5−/− versus control mice. These included alterations in several genes in NK cells that mirrored observations in NKs from HIV-infected humans expressing less RAB11FIP5, although Rab11Fip5 was dispensable for NK cell cytolytic activity. Notably, immunized RAB11FIP5−/− mice had lower IL4 expression in CD4+ T follicular helper cells and showed lower TNF expression in CD8+ T cells. Likewise, TNF-α production by human CD8+ T cells correlated with PBMC RAB11FIP5 expression. These observations in RAB11FIP5−/− mice suggest a role for Rab11Fip5 in regulating cytokine responses.
Regulatory T Cells in Angiogenesis
Authors: Lužnik Zala , Anchouche Sonia , Dana Reza , Yin Jia 
Published: November 2020

Abstract
Regulatory T cells (Tregs) are crucial mediators of immune homeostasis. They regulate immune response by suppressing inflammation and promoting self-tolerance. In addition to their immunoregulatory role, a growing body of evidence highlights the dynamic role of Tregs in angiogenesis, the process of forming new blood vessels. Although angiogenesis is critically important for normal tissue regeneration, it is also a hallmark of pathological processes, including malignancy and chronic inflammation. Interestingly, the role of Tregs in angiogenesis has been shown to be highly tissue- and context-specific and as a result can yield either pro- or antiangiogenic effects. For these reasons, there is considerable interest in determining the molecular underpinnings of Treg-mediated modulation of angiogenesis in different disease states. The present review summarizes the role of Tregs in angiogenesis and mechanisms by which Tregs regulate angiogenesis and discusses how these mechanisms differ in homeostatic and pathological settings.
Quantifying and reporting cardiac findings in imaging of COVID-19 patients
Authors: Mishra Ajay Kumar , Lal Amos , Sahu Kamal Kant , Kranis Mark , Sargent Jennifer 
Published: November 2020

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to be a public health emergency and a pandemic of international concern. As of April 31st, the reported cases of COVID-19 are three million in 186 countries. Reported case fatality has crossed 200 thousand among which more than fifty thousand has been in the USA. Most patients present with symptoms of fever, cough, and shortness of breath following exposure to other COVID-19 patients. Respiratory manifestations predominate in patients with mild, moderate, severe illness. Imaging of patients with COVID-19 consistently reports various pulmonary parenchymal involvement. In this article we wanted to reinforce and review the various reported imaging patterns of cardiac and mediastinal involvement in COVID-19 patients. Among patients with COVID 19 who underwent various imaging of chest various cardiac findings including pericardial effusion, myocarditis, cardiomegaly has been reported. Most of these findings have been consistently reported in patients with significant acute myocardial injury, and fulminant myocarditis. Acute biventricular dysfunction has also been reported with subsequent improvement of the same following clinical improvement. Details of cardiac MRI is rather limited. In a patient with clinical presentation of acute myocarditis, biventricular myocardial interstitial edema, diffuse biventricular hypokinesia, increased ventricular wall thickness, and severe LV dysfunction has been reported. Among patients with significant clinical improvement in LV structure and function has also been documented. With increasing number of clinical cases, future imaging studies will be instrumental in identifying the various cardiac manifestations, and their relation to clinical outcome.
A caminhabilidade
Authors: Richard Pitilin Taiany , Da Penha Sanches Suely 
Published: November 2020

A mobilidade urbana nas cidades tem apresentado diversos problemas. Ciclistas e pedestres enfrentam desafios para conseguir espaço para se deslocarem junto aos veículos motorizados que vêm ganhando cada vez mais espaço nas cidades. A caminhabilidade pode ser uma ferramenta importante para avaliar o quanto o ambiente é atrativo para pedestres. Este artigo busca contribuir para uma compreensão dos caminhos que a produção científica sobre caminhabilidade vem tomando nos últimos anos apresentando uma análise bibliométrica referente ao período dos anos de 2000 a 2018. Como resultados, são apresentadas as análises de 1.112 publicações segundo a evolução quantitativa das mesmas no recorte temporal selecionado e suas contribuições por país e por pesquisador. Pode-se verificar que as pesquisas sobre caminhabilidade estão em ascensão e que os Estados Unidos assumem o ranking de país com mais publicações na área.
Efficacy and safety of netakimab in patients with psoriatic arthritis: results of the phase III PATERA clinical study
Authors: Korotaeva T. V. , Mazurov V. I. , Lila A. M. , Gaydukova I. Z. , Bakulev A. L. , Samtsov A. V. , Khairutdinov V. R. , Eremeeva A. V. , Morozova M. A. 
Published: November 2020

Netakimab (NTK) is a humanized anti-interleukin-17А (IL-17A) monoclonal antibody approved for the treatment of psoriatic arthritis, ankylosing spondylitis, moderate to severe psoriasis. Here, we present the results of the 24-weeks double blind period of the PATERA study.Objective. The objective of the study was to evaluate the efficacy and safety of NTK compared to placebo in patients with psoriatic arthritis (PsA).Patients and methods. 194 patients with active PsA with an inadequate response to previous therapy with nonsteroidal anti-inflammatory drugs, conventional or biologic disease-modifying antirheumatic drugs, were randomized in a 1:1 ratio to receive subcutaneous 120 mg NTK or placebo at weeks 0, 1, 2, 4, 6, 8, 10, 14, 18, 22. At week 16 ACR20 (20% improvement in the American College of Rheumatology response criteria) non-responders in placebo group were reassigned to NTK in a blinded manner. The primary endpoint was the proportion of patients achieved ACR20 response at week 24.Results. 82,5% of patients in the NTK group and 9.3% of patients in the placebo group achieved ACR20 at week 24 with the 95% CI [0,63; 0,84] (p < 0,0001). Skin manifestations and axial disease significantly improved with NTK. The safety profile of NTK was comparable to placebo. The most frequent treatment-related AEs were expected and common for all other IL-17 inhibitors: increased alanine aminotransferase (ALT), infections, lymphopenia.Conclusion. NTK in the dose of 120 mg has superior efficacy over placebo in patients with active psoriatic arthritis. The safety profile is consistent with other IL-17 inhibitors.
Medical and social care program for patients with psoriasis and/or psoriatic arthritis eligible for biological dmards in real clinical practice
Authors: Kruglova L. S. , Korotaeva T. V. 
Published: November 2020

High prevalence in different age groups, a significant decrease in patient’s quality of life, and potentially unfavorable outcomes, especially in association with comorbid pathologies define the medico-social significance of psoriasis. The article analyzes the clinical and anamnestic data obtained within the program of medical and social support of patients with psoriasis (PsO) and / or high-to-moderate severity psoriatic arthritis (PsA) “Take control of psoriasis”, launched by ROOI “Human Health” in the conjunction with the Interregional Charitable Public Organization “Skin and Allergic Diseases”. The study involved 20 physicians (8 dermatologists and 12 rheumatologists) from 11 cities and regions of Russia. The program lasted for 3 months and included one-time epidemiologic data collection of 564 patients and educational sessions, aimed to inform patients about their disease features, risk factors, and current international approaches to diagnostics. Every third patient demonstrated the features of both – psoriatic arthritis and psoriasis, established by two specialties – dermatologists and rheumatologists co-existing PsO+PsA in the majority of patients (94%). Patients with various forms of PsO and PsA had comorbid conditions, with prevailing cardiovascular, endocrine and metabolic disorders. Cardiovascular diseases prevailed in the structure of comorbid pathology showing 44% incidence, followed by endocrine disorders (metabolic syndrome, diabetes mellitus) diagnosed in 23% sometimes associated with other diseases in a proportion of patients; 37% patients were overweight or obese based on BMI, especially those receiving biologics. 58% and 49% of patients in the age group of 45–59 years received biologic therapy under the supervision of dermatologists and rheumatologists, respectively. In contrast, patients aged 18–44 years were more likely to be on biologic therapy administered by a rheumatologist – 43%, with only 27% treated by dermatologists. Among all patients on biologic therapy dermatological patients’ mean age was 47.95 years and rheumatological – 40.84 years. Therapy with biologics made it possible to achieve PASI 75 in PsO and minimal disease activity in PsA significantly more often (in 95% and 72% of patients) than therapy with conventional DMARDs / tsDMARD (in 43% and 27%) and other types of therapy (in 64% and 14%, respectively).
Assessment of cardiovascular risk in patients with crystal-induced arthritides and rheumatoid arthritis by the ATP III and Reynolds Risk Score
Authors: Eliseev M. S. , Novikova A. M. , Zhelyabina O. V. , Gerasimova E. V. , Ilyinykh E. V. , Popkova T. V. , Panevin T. S. , Nasonov E. L. 
Published: November 2020

Cardiovascular risk (CVR) in patients with calcium pyrophosphate crystal deposition disease (CPPD) has not been studied, and the optimal method for assessing it has not been established yet.Objective: Evaluation of CVR and comparison of results using Adult Treatment Panel III (ATP III) and Reynolds Risk Score (RRS) scales in patients with CPPD, gout, rheumatoid arthritis (RA) and in the control group.Materials and methods: Cross-sectional, single-center study performed by case-control method. There are 42 patients with CPPD in main group, 42 patients with gout and RA in the comparison groups are, 42 healthy volunteers in the control group. The survey included measurements of anthropometric measures, blood pressure (BP), serum glucose, creatinine, cholesterol (TC), high density lipoproteins (HDL), low density lipoproteins (LDL), C-reactive protein (CRP). CVR was assessed on ATP III and RRS scales, comparison of its evaluation results was carried out between groups and between scales within groups.Results and discussion: Most of the parameters in the compared groups did not differ. However, HDL CS levels were significantly higher in patients with CPPD and in the control group than in RA and gout (p<0.05). In addition, in patients with gout and RA, systolic BP was higher than in CPPD and in control (p<0.05).CRP in CPPD was lower than in gout and RA and was not significantly different from this indicator in the control group. Its median was 3.8 [1.0; 12.4], 8.5 [4.1; 12.9] (р<0.05), 8.6 [4.1; 20.6] (р<0.05), 1.5 [0.8; 2.6] mg/l (p>0.05). The CRP > 5 mg/L in CPPD and in the control group was greater than in RA (p<0.05) and gout (p<0.05), but CRP≥5 mg/L was determined in 18 patients (43%) with CPPD and only in 3 (7%) people in the control group (p<0.05). A high and very high risk of cardiovascular disease (CVD) on the ATP III scale in CPPD was noted in 5 (12%) in gout – in 7 (17%), in RA – in 9 (21%) and in the control group – in 8 (19%) cases. Its frequency in all groups was comparable.A high and very high risk of CVD for RRS was identified in 9 (21%), 14 (33%), 12 (29%) and 7 (17%) cases, respectively.Conclusions: CVR under CPPD, RA and gout is comparable and quite high. The RRS scale may be a more objective method of assessing CVD risk in patients with CPPD, gout and RA.
The New "Covid-19" Home Office Worker: Evolving Computer-Human Interactions and the Perceived Value of Workplace Technology
Authors: Kelly Jamie 
Published: November 2020

The context for this paper is the ongoing Covid-19 Global Pandemic and the guidance from the majority of nation-state governments for all central office based type workers to completely shift to working from home, advice which business and organisations adopted. Recent European research has established that 85% [1] of knowledge workers up to the Covid-19 Pandemic worked 80% or more of their time in a central office environment. Suddenly these office workers had to relocate their work into their homes without any opportunities for their employers to plan this move. Part of the challenge was access to the right technology. This problem was quickly resolved by the purchase of the relevant technology but not necessarily the new human-computer interaction mode. The focus of the field research was to assess the evolving human-computer of the office-based worker before the Covid-19 Pandemic. The paper has two intended outcomes. First, to provide short term insights to better understand the impact of rapid change of physical and technology-centric workspaces, due to Covid-19 on user behaviours and experience. Second to use the research to deliver better user experience design and collaboration and how technologies such Augmented Reality could enhance that experience.
FACTORES DE RIESGO FAMILIAR EN EL CONSUMO DE DROGAS Y SU RELACIÓN CON LA CONDUCTA ANTISOCIAL EN ADOLESCENTES. DISTRITO DE SALUD 09D08. 2019
Authors: Hidalgo Candell Cassandra Carolina 
Published: November 2020

Introducción: El consumo de drogas y las conductas antisociales en adolescentes son un problema social y de salud pública que afecta gravemente a la mayoría de los países y Ecuador no es la excepción, ya que, requiere de acciones preventivas inmediatas y de promoción de la salud. Objetivo: Determinar los factores de riesgo familiar en el consumo de drogas y su relación con las conductas antisociales en adolescentes del distrito 09D08. SALUD. 2018 – 2019. Materiales y métodos: Esta investigación se realizó bajo el paradigma positivista con enfoque cuantitativo. La modalidad de investigación es de campo de tipo descriptivo, no experimental, y de corte transversal. La población estuvo constituida por 234 adolescentes y la muestra por 177. La técnica empleada fue la encuesta y suinstrumento el cuestionario constituido por 59 items. Resultados: el 74% de adolescentes presenta economía familiar baja el 57% de los adolescentes indican manifestaciones de abuso, descuido y abandono dentro de su entorno familiar. El 53% de los adolescentes consumieron alcohol cada mes, mientras el 28% lo hizo cada semana y el 20% a diario y el 69% de los adolescentes admite robar, cosas o dinero. Conclusiones: se encontró que los principales factores influyentes son los ambientes familiares abusivos, violentos y permisivos. Los adolescentes durante la sesión del grupo focal, manifestaron la situación familiar influyó en sus conductas antisociales y consumo de drogas.
FACTORES QUE INFLUYEN EN LA DECISIÓN PARA INICIAR EL TRATAMIENTO DE MODALIDAD DE DIÁLISIS EN PACIENTES DEL HOSPITAL “ABEL GILBERT PONTÓN” – 2019
Authors: Acebo Murillo Mariela del Rocío , Jiménez Luna Corina Lisbeth , Guerrero Hidalgo Luis Enrique , Cabanilla Proaño Erika Alexandra 
Published: November 2020

Introducción: La insuficiencia renal crónica es la cuarta causa de mortalidad en Ecuador, además, es un problema de salud pública por su elevada incidencia, prevalencia, costoselevados en la atención de salud, y también por su morbimortalidad, que va en aumento. Objetivo: Determinar los factores que influyen en las decisiones sobre el inicio del tratamientode modalidad de diálisis en los pacientes con problemas renales crónicos para tener una conceptualización clara y precisa sobre esta técnica, evidenciando las ventajas y desventajas de las terapias dialíticas. Materiales y métodos: la metodología se inserta en el paradigma positivista bajo el enfoque cuantitativo. La modalidad fue de campo, de nivel descriptivo-deductivo, de diseño no experimental, de corte trasversal. La población está conformada por, aproximadamente, 500 pacientes ingresados en el área de Nefrología del Hospital AbelGilbert Pontón durante enero a junio del 2019. La muestra se calculó mediante un muestreo probabilístico aleatorio simple representado por 95 pacientes ingresados por vez primera al área nefrológica. Resultados: indicaron que desde el género se afectan porcentajes similares cercanos al 50%, los intervalos de edades más afectadas por las ERC, es el segmento entre 50 y 80 años donde se agrupa el 64% de los afectados, según su procedencia el 79% provienen del área urbana, el 82% de los pacientes no saben que es una diálisis, el 85% no conocen las modalidades de diálisis que existen y más del 90% de los pacientes admiten tener poco o ningún conocimiento para tomar una decisión en cuanto al tratamiento a seleccionar. Conclusión: el estudio determinó que la causa más relevante en torno a la capacidad de los pacientes para decidir sobre su terapia dialítica es inherente a la información que poseen sobre ésta. Finalmente se sugiere un programa de formación integral como salida a la causa fundamental detectada.
Variability in gaseous elemental mercury at Villum Research Station, Station Nord, in North Greenland from 1999 to 2017
Authors: Skov Henrik , Hjorth Jens , Nordstrøm Claus , Jensen Bjarne , Christoffersen Christel , Bech Poulsen Maria , Baldtzer Liisberg Jesper , Beddows David , Dall'Osto Manuel , Christensen Jesper Heile 
Published: November 2020

Abstract. Mercury is ubiquitous in the atmosphere, and atmospheric transport
is an important source for this element in the Arctic. Measurements of
gaseous elemental mercury (GEM) have been carried out at Villum Research
Station (Villum) at Station Nord, situated in northern Greenland. The
measurements cover the period 1999–2017, with a gap in the data for the
period 2003–2008 (for a total of 11 years). The measurements were compared
with model results from the Danish Eulerian Hemispheric Model (DEHM)
that describes the contribution from direct anthropogenic transport, marine
emissions and general background concentration. The percentage of time spent over different surfaces was calculated by back-trajectory analysis, and the reaction kinetics were determined by a comparison with ozone. The GEM measurements were analysed for trends, both seasonal and annual. The only significant trends found were negative ones for the winter and autumn months. Comparison of the measurements to simulations using the Danish Eulerian Hemispheric Model (DEHM) indicated that direct transport of anthropogenic emissions of mercury accounts for between 14 % and 17 % of the measured mercury. Analysis of the kinetics of the observed atmospheric mercury depletion events (AMDEs) confirms the results of a previous study at Villum of the competing reactions of GEM and ozone with Br, which suggests that the lifetime of GEM is about a month. However, a GEM lifetime of 12 months gave the best agreement between the model and measurements. The chemical lifetime is shorter, and thus, the apparent lifetime appears to be the result of deposition followed by reduction and re-emission; for this reason, the term “relaxation time” is preferred to “lifetime” for GEM. The relaxation time for GEM causes a delay between emission reductions and the effect on actual concentrations. No significant annual trend was found for the measured concentrations of GEM over the measurement period, despite emission reductions. This is
interesting, and together with low direct transport of GEM to Villum as
found by the DEHM model, it shows that the dynamics of GEM are very complex. Therefore, in the coming years, intensive measurement networks are needed to describe the global distribution of mercury in the environment as the use of models to predict future levels will still be highly uncertain. The situation is increasingly complex due to global changes that most likely will change the transport patterns of mercury, not only in the atmosphere but also between matrixes.
Reliability analysis of offshore wind turbine foundations under lateral cyclic loading
Authors: Zorzi Gianluca , Mankar Amol , Velarde Joey , Sørensen John D. , Arnold Patrick , Kirsch Fabian 
Published: November 2020

Abstract. The design of foundations for offshore wind turbines (OWTs) requires the assessment of long-term performance of the soil–structure interaction (SSI), which is subjected to many cyclic
loadings. In terms of serviceability limit state (SLS), it has to be ensured that the load on the foundation does not exceed the operational tolerance prescribed by the wind turbine manufacturer throughout its lifetime. This work aims at developing a probabilistic approach along with a reliability framework with emphasis on verifying the SLS criterion in terms of maximum allowable rotation during an extreme cyclic loading event. This reliability framework allows the quantification of uncertainties in soil properties and the constitutive soil model for cyclic loadings and extreme environmental conditions and verifies that the foundation design meets a specific target reliability level. A 3D finite-element (FE) model is used to predict the long-term response of the SSI, accounting for the accumulation of permanent cyclic strain experienced by the soil. The proposed framework was employed for the design of a large-diameter monopile supporting a 10 MW offshore wind turbine.
Quentin in Arthur Miller's After the Fall and Tennessee Williams's Small Craft Warnings
Authors: Shannon Elle 
Published: November 2020

Abstract
Arthur Miller's After the Fall and Tennessee Williams's Small Craft Warnings have many similarities as both plays appear to be semiautobiographical. However, where Miller writes through an optimistic lens, Williams does the opposite. The two plays address the difficulties of relationships—both platonic and romantic—regarding hope and despair. However, the perspectives of each of their protagonists, who are both named Quentin, process their lives and futures in contrasting ideologies. As Miller's Quentin seeks a new beginning, he must first process his past, which revolves around the women in his life. Williams's Quentin grapples with the reality of being gay in a homophobic society. The importance of each playwright choosing the name Quentin and the meaning of the name, “the fifth,” includes the religious connotations of the number five. Miller and Williams use their plays to explore their futures, with each breaking the fourth wall, like a confessional.