bluuebunny/crossref_metadata_2025_split huggingface dataset:
Healthcare workers’ stress when caring for COVID-19 patients: An altruistic perspective
Authors: Wang Hui , Liu Yu , Hu Kaili , Zhang Meng , Du Meichen , Huang Haishan , Yue Xiao 
Published: July 2020

Background: When the contagious COVID-19 spread worldwide, the frontline staff faced unprecedented excessive work pressure and expectations of all of the society. Objective: The aim was to explore healthcare workers’ stress and influencing factors when caring for COVID-19 patients from an altruistic perspective. Methods: A cross-sectional, descriptive study was conducted in a tertiary hospital during the outbreak of COVID-19 between February and March 2020 in Wuhan, the capital city of Hubei province in China. Data were collected from 1208 healthcare workers. Descriptive statistics and multiple linear regression were used to analyze the data. Ethical considerations: Research ethics approval (with the code of TJ-IRB20200379) was obtained from Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology. Written informed consent was also received from participants. Results: Less than 60% of participants chose moderate or severe stress on all stressors, indicating a low stress level among healthcare workers. The main source of stress among frontline healthcare workers caring for COVID-19 patients came from the fear of being infected, the fear of family members being infected, and the discomfort caused by protective equipment. Frontline staff who were nurses, were married, and had worked more than 20 days suffered higher stress, whereas rescue staff showed lower stress. Conclusion: The healthcare workers caring for patients with COVID-19 had low stress level, although they still had the fear of being infected or uncomfortable feeling caused by personal protective equipment. A low stress level among healthcare workers indicated their professional devotion and altruism during COVID-19 epidemic. Medical institutions and the government should continue to strengthen infection prevention measures and provide more comprehensive care involving families of frontline healthcare workers, especially nurses and married staff. It will be a lesson to other countries that awaking healthcare workers’ inside motivation and providing necessary support from government and society were significant.
Use of active learning and simulation to teach pharmacy students order verification and patient education best practices with oral oncolytic therapies
Authors: Duffy Alison P , Henshaw Alyssa , Trovato James A 
Published: July 2020

Introduction The primary objective of this study was to describe the incorporation of the flipped classroom model and use of real-life oncology patients to facilitate student learning of oral oncolytic best safety practices and patient counseling. The secondary objective was to assess the impact of the flipped classroom learning activity on students’ perceived confidence. Methods This study was a prospective, single center, flipped classroom learning activity and pre/post assessment survey administered to third year doctor of pharmacy students enrolled in the Oncology Pharmacotherapy didactic elective in 2016 and 2017. A pre/post survey was used to assess student’s perceived confidence with oral oncolytic best practice competencies. Results Ten students participated in the flipped classroom learning activity and survey. Five students completed both the pre- and postsurvey. The overall change in student’s mean scores for their confidence of oral oncolytic competencies improved significantly from 3 to 4.1 on a 6-point Likert Scale ( p = 0.03) following the learning activity. Students perceived confidence in performing oral oncolytic order verification increased following the implementation of a flipped classroom learning activity and use of real-life cancer oncology patients. Conclusion This study describes the development and implementation of a flipped classroom learning activity and use of real-life patients with cancer that can be implemented at other institutions of higher education in a didactic or experiential learning environment. Additionally, this study demonstrated a potential benefit in student learning.
A validation study for remote testing of cognitive function in multiple sclerosis
Authors: Barcellos Lisa F , Horton Mary , Shao Xiaorong , Bellesis Kalliope H , Chinn Terrence , Waubant Emmanuelle , Bakshi Nandini , Marcus Jackie , Benedict Ralph HB , Schaefer Catherine 
Published: July 2020

Objectives: Determine the validity and reliability of a remote, technician-guided cognitive assessment for multiple sclerosis (MS), incorporating the Symbol Digit Modalities Test (SDMT) and the California Verbal Learning Test, Second Edition (CVLT-II). Methods: In 100 patients, we compared conventional in-person testing to remote, web-assisted assessments, and in 36 patients, we assessed test–retest reliability using two equivalent, alternative forms. Results: In-person and remote-administered SDMT ( r = 0.85) and CVLT-II ( r = 0.71) results were very similar. Reliability was adequate and alternative forms of SDMT ( r = 0.92) and CVLT-II ( r = 0.81) produced similar results. Conclusions: Findings indicate remote assessment can provide valid, reliable measures of cognitive function in MS.
Measurement of white matter fiber-bundle cross-section in multiple sclerosis using diffusion-weighted imaging
Authors: Storelli Loredana , Pagani Elisabetta , Preziosa Paolo , Filippi Massimo , Rocca Maria A 
Published: July 2020

Background: When investigating white matter (WM) microstructure, the axonal fiber orientation should be considered. Constrained spherical deconvolution (CSD) is a diffusion-weighted imaging (DWI) method that estimates distribution of fibers within each imaging voxel. Objective: To study fiber-bundle cross-section (FC) as measured by CSD in multiple sclerosis (MS) patients versus healthy controls (HCs). Methods: DWI and three-dimensional (3D) T1-weighted magnetic resonance imaging (MRI) were obtained from 45 MS patients and 45 HCs. We applied fixel-based morphometry analysis to assess differences of FC in MS against HCs and voxel-based analysis of fractional anisotropy (FA). Results: We found a significant widespread reduction of WM FC in MS compared to HCs. The decrease in FA was less extensive, mainly located in regions with high lesion occurrence such as the periventricular WM and the corpus callosum. Progressive MS patients showed a significant FC reduction in the right anterior cingulum, bilateral cerebellum, and in several mesencephalic and diencephalic regions compared to relapsing-remitting MS patients. Conclusion: The CSD method can be applied in MS for a fiber-specific study of WM microstructure and quantification of FC. Fixel-based findings offered greater anatomical specificity and biological interpretability by identifying tract-specific differences and allowed substantial abnormalities to be detected.
Right atrial appendage aneurysm in a fetus—Does precise prenatal diagnosis matter?
Authors: Ivanitskaya Olga , Sologub Yulia , Tsayuk Yulia , Zagray Alexey , Kim Aleksei 
Published: July 2020

Introduction Congenital malformations of the right atrium—aneurysms and diverticula—are rare heart defects with only a few cases having been described prenatally. Early diagnosis of these anomalies is extremely important due to the possibility of such serious complications such as supraventricular arrhythmia, thromboembolic events and sudden death. Topic Description Although each of these anomalies is well known, there are still significant discrepancies in diagnosis. At the same time, there is no essential difference in the postnatal management of patients with right atrial aneurysms or diverticula. Treatment mode varies between centers and is selected individually depending on the presence of symptoms. Discussion We discuss the problems of terminology, ultrasound criteria and prenatal differential diagnosis, anatomic and histological features and current limitations for the accurate diagnosis of right atrial aneurysms and diverticula in utero. As a clinical example, we describe a case of right atrial appendage aneurysm diagnosed in a fetus. Conclusions Considering the prenatal diagnostic difficulties and similar management of such patients after birth, we suggest avoiding the use of exact terms in the fetus, leaving the precise diagnosis for the postnatal period.
Thiopurine S-methyltransferase genetic polymorphisms in adult patients with inflammatory bowel diseases in the Latvian population
Authors: Zalizko Polina , Stefanovics Juris , Sokolovska Jelizaveta , Paramonova Natalia , Klavina Evija , Erts Renars , Rovite Vita , Klovins Janis , Pukitis Aldis 
Published: July 2020

Background: Thiopurine methyltransferase (TPMT) plays a significant role in the metabolism of thiopurines, and, for patients with inflammatory bowel disease (IBD), it is useful to perform TPMT genotyping prior to azathioprine (AZA) treatment. In this study, we determined TPMT gene polymorphisms in a cohort of IBD patients in Latvia. Methods: DNA samples were obtained from 244 IBD patients, and qPCR was performed for detection of rs1800462, rs1800460, and rs1142345 single-nucleotide polymorphisms (SNPs). Three common, non-functional TPMT alleles ( TPMT*2, *3B, and *3C) were identified (women, 51%; men, 49%). TPMT*2, *3A, *3B, and *3C allelic variants detected using qPCR were consistent with restriction fragment length polymorphism (RFLP) data. Results: Among patients, 78% had ulcerative colitis and 22% had Crohn’s disease, with 93.9% of the former carrying a wild-type homozygous TPMT*1/*1 genotype and 6.1% carrying heterozygous genotypes. The most frequent polymorphisms were TPMT*1/*3A (5.3%: two variants: TPMT*3B and TPMT*3C), TPMT*1/*3C (0.4%), and TPMT*1/*2 (0.4%). None of the patients carried a TPMT*3B polymorphism and no patients were homozygous for any mutation. Conclusion: This is the first study to identify TPMT gene polymorphisms in adult IBD patients in Latvia. The results indicate that the frequency of common TPMT alleles is similar to that of other European populations.
Dynamic transactional model: a framework for communicating public health messages via social media
Authors: Parackal M , Parackal S , Mather D , Eusebius S 
Published: July 2020

Aims: Social media, because of its broad coverage, is an attractive option for communicating public health messages. However, the lack of a theoretical framework, supporting the two-way communication of social media, is holding back its development and use. This study investigated the suitability of a dynamic transactional model (DTM) of communication for explaining the use of social media for communicating public health messages. Methods: The study was carried out on ‘Don’t know? Don’t drink’, a Facebook campaign against drinking alcohol during pregnancy that targeted women of childbearing age in New Zealand. The comments generated were analysed for two features of DTM, namely inter- and intra-transaction, by examining the plurality of topics and polarity of sentiments, using text-mining techniques. Results: The analysis of the textual data revealed nine independent topics, confirming the plurality of topics. The conversation contained both positive and negative terms, establishing the polarity of sentiment. Conclusions: This study verified the two DTM features (inter- and intra-transaction) in the comments produced by the ‘Don’t know? Don’t drink’ campaign implemented on Facebook. DTM exhibited the potential to be a theoretical framework for recommending and evaluating social media sites like Facebook for communicating public health messages.
An investigation of the status and maturity of hospitals’ health information governance in Victoria, Australia
Authors: Kwan Helen , Riley Merilyn , Prasad Natasha , Robinson Kerin 
Published: July 2020

Background: Health information governance (IG) in Australian hospitals was hitherto unexplored. Objectives: To determine hospitals’ health IG status and maturity in Victoria, Australia, identify drivers and barriers affecting IG adoption, examine electronic health data breach response plan usage and assess employees’ electronic data breach awareness. Method: Mixed-methods descriptive study utilising an online survey of directors – clinical/health information services and chief health information managers (HIMs) in Victorian hospitals, ≥50 beds. Results: Response rate: 42.9% ( n = 36). Fifty percent ( n = 17) of respondent-hospitals had an IG program. IG equally supported decision-making and risk identification and prevention. The greatest potential organisational damages from system disruption or failure were information loss (66.7%) and clinical risks (63.9%). HIMs in 15 (55.6%) hospitals had knowledge to monitor and detect electronic data breaches. Staff in 19 (70.4%) hospitals knew who to inform about a suspected breach. Most hospitals had mature health information-related IG practices, most (88.9%, n = 24) provided IG-related education, 77.8% ( n = 21) regularly reviewed data breach response plans. The strongest IG drivers were privacy-security compliance and changes to data capture or documentation practices (82.8%, n = 24); the greatest barriers were implementation complexity (57.1%, n = 16) and cost (55.6%, n = 15). Conclusion: These baseline Australian data show 50% of respondent-hospitals had no formal health IG program. Privacy-security compliance, and audits, needed improvement; however, most hospitals had well-developed medical record/health information IG-relevant schedules, policies and practices. HIMs, the professionals most engaged in IG, required upskilling in electronic data breach detection.
Physical Fitness and Bone Health in Young Athletes and Nonathletes
Authors: Henriques-Neto Duarte , Magalhães João P. , Hetherington-Rauth Megan , Santos Diana A. , Baptista Fátima , Sardinha Luís B. 
Published: July 2020

Background: Physical activity (PA) and physical fitness (PF) are crucial for bone health. However, children participating in competitive sports with high PA are at a greater risk of fracture from trauma or overuse. Given the importance of bone development during adolescence, associations between commonly used physical fitness tests with distal third radius (R-SoS) and midshaft tibia (T-SoS) speed of sound by quantitative ultrasound were assessed in adolescent athletes and nonathletes. Hypothesis: The relationship between physical fitness tests and R-SoS and T-SoS will differ depending on sex and athletic status. Study Design: Cross-sectional study. Level of Evidence: Level 3. Methods: Physical fitness of 285 boys (156 athletes) and 311 girls (74 athletes) aged 10 to 18 years was assessed through strength, speed, agility, and cardiorespiratory tests. Linear regression was used to assess the associations of physical fitness tests with R-SoS and T-SoS. Results: For boys, favorable associations were observed between physical fitness tests with R-SoS in athletes and T-SoS in both athletes and nonathletes ( P < 0.05). For nonathlete girls, favorable associations were found for handgrip (R-SoS and T-SoS, both P < 0.05), whereas the progressive aerobic cardiovascular endurance run, vertical jump, speed at 20 m and 40 m were only favorably associated with T-SoS. For athlete girls, the association between handgrip ( P = 0.03), vertical jump, and 4 × 10 m shuttle run ( P < 0.05) with T-SoS was significantly related to a bone outcome. Conclusion: The handgrip test and vertical jump were associated with T-SoS in boys and girls independent of sport status. These results suggest that physical fitness is associated with bone health in adolescents, particularly boys, and that the relationship between physical fitness and bone may differ depending on sex and athletic status. Clinical Relevance: Physical fitness tests are simple, easy-to-use tools for monitoring bone health and should be used by sport and health professsionals to promote healthy sport participation and prevent bone injuries.
Thrower’s Exostosis of the Shoulder: A Systematic Review With a Novel Classification
Authors: Freehill Michael T. , Mannava Sandeep , Higgins Laurence D. , Lädermann Alexandre , Stone Austin V. 
Published: July 2020

Background: A variety of thrower’s exostoses are grouped under the term Bennett lesion, which makes understanding diagnosis and treatment difficult. Purpose: To identify all types of reported thrower’s and overhead athlete’s exostoses and categorize them into a classification system to allow a morphology-based classification. Study Design: Systematic review; Level of evidence, 4. Methods: A systematic review of all articles pertaining to Bennett lesions and thrower’s exostosis was performed. The classification and treatments were evaluated to describe the types, proposed causes, diagnosis, and treatment options. Results: A total of 27 studies were included in the systematic review. The anatomic locations referenced in the study demonstrated posteroinferior, posterior, and posterosuperior glenoid lesions. Aggregate radiographic data demonstrated 158 of 306 patients (52%) with a thrower’s exostosis of any type and location. Of these 158 patients with a radiographic lesion, 119 (75%) patients were symptomatic. The locations were posteroinferior in 110 patients (70%), directly posterior in 2 patients (1.3%), posterosuperior in 44 patients (28%), and unknown in 2 patients (1.3%). Avulsed lesions were present in 9 (5.7%) posteroinferior lesions, 0 direct posterior lesions, and 2 (1.3%) posterosuperior lesions. Treatment plans included both nonoperative and operative strategies, but operative intervention was more commonly reported for detached lesions. After operative intervention, only 61% of reported athletes returned to preinjury performance. Conclusion: Based on a comprehensive review of the literature, we identified several anatomic locations for a thrower’s exostosis beyond the classic Bennett lesion. We categorized the reported exostoses into a new classification system for description of location and type (subperiosteal or free fragment) of the thrower’s exostosis, which may be used to study future treatments. Current treatment strategies recommend that surgical treatment of thrower’s exostosis is considered only after exhausting nonoperative management because reported return to sport is variable after surgery. The effectiveness of excision or repair for both subperiosteal and detached lesions has not been established.
COVID-19 Considerations in Pediatric Dentistry
Authors: Bahramian H. , Gharib B. , Baghalian A. 
Published: July 2020

One of the most important current medical concerns across the globe is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, which has been designated by the World Health Organization as a novel viral pneumonia named coronavirus disease 2019 (COVID-19). COVID-19 has substantially affected all aspects of human lives and forced most people to self-quarantine themselves and stay home in order to remain safe. As pediatric dentists as a part of the health care system deferring elective procedures, we are obliged to manage emergency situations such as cellulitis, severe tooth pain, and dental trauma. Therefore, we need to beware of the symptoms and risks of the emerging disease and, accordingly, change the policies in our offices to minimize the risk of transmission while checking up and treating our patients in the safest possible way. Knowledge Transfer Statement: This article aims to acquaint clinicians treating pediatric patients with COVID-19 hazards and delineate the steps required for minimizing cross-infection in case of providing emergency treatment to children in dental offices.
Evolutionary chemical binding similarity approach integrated with 3D-QSAR method for effective virtual screening
Authors: Durai Prasannavenkatesh , Ko Young-Joon , Pan Cheol-Ho , Park Keunwan 
Published: July 2020

AbstractBackgroundDespite continued efforts using chemical similarity methods in virtual screening, currently developed approaches suffer from time-consuming multistep procedures and low success rates. We recently developed a machine learning-based chemical binding similarity model considering common structural features from molecules binding to the same, or evolutionarily related targets. The chemical binding similarity measures the resemblance of chemical compounds in terms of binding site similarity to better describe functional similarities that arise from target binding. In this study, we have shown how the chemical binding similarity could be used in virtual screening together with the conventional structure-based methods.ResultsThe chemical binding similarity, receptor-based pharmacophore, chemical structure similarity, and molecular docking methods were evaluated to identify an effective virtual screening procedure for desired target proteins. When we tested the chemical binding similarity method with test sets of 51 kinases, it outperformed the traditional structural similarity-based methods as well as structure-based methods, such as molecular docking and receptor-based pharmacophore modeling, in terms of finding active compounds. We further validated the results by performing virtual screening (using the chemical binding similarity and receptor-based pharmacophore methods) against a completely blind dataset for mitogen-activated protein kinase kinase 1 (MEK1), ephrin type-B receptor 4 (EPHB4) and wee1-like protein kinase (WEE1). The in vitro kinase binding assay confirmed that 6 out of 13 (46.2%) for MEK1 and 2 out of 12 (16.7%) for EPHB4 were newly identified only by the chemical binding similarity model.ConclusionsWe report that the virtual screening results could further be improved by combining the chemical binding similarity model with 3D-QSAR pharmacophore and molecular docking models. Not only the new inhibitors are identified in this study, but also many of the identified molecules have low structural similarity scores against already reported inhibitors and that show the revelation of novel scaffolds.