bluuebunny/crossref_metadata_2025_split huggingface dataset:
An integrative Bayesian network approach to highlight key drivers in systemic lupus erythematosus
Authors: Maleknia Samaneh , Salehi Zahra , Sharifi-Zarchi Ali , Rezaei-Tabar Vhid , Kavousi Kaveh 
Published: January 2020

Abstract
Background: To perceive a comprehensive illustration of the systemic lupus erythematosus (SLE), as a complex and multifactorial disease, draw a biological challenge. Dealing with this challenge needs employing sophisticated bioinformatics algorithms to discover the unknown aspects. This study aimed to distinguish key molecular characteristics of SLE pathogenesis, which may serve as effective targets for therapeutic intervention. Methods: In the present study, six gene expression microarray datasets included SLE patients (n=220) and healthy controls (n=135) were collected. We integrated the datasets by cross-platform normalization. Subsequently, through BNrich method, the structures of Bayesian networks (BNs) were extracted from SLE, TCR and BCR signaling pathways and the parameters of BNs were estimated using integrated datasets. Finally, a meta-analysis was performed to distinguish the signaling pathways alterations in the SLE pathogenesis. Results: We identified the most dysregulated genes involved in the clearance mechanism (most inhibition in MACROH2A2 and H4C9, most activation in SNRPD3, MACROH2A1 and RO60). Augmented autoantigens presentation by MHCII (HLA-DQA1, HLA-DOB and HLA-DPB1) and CD80 and CD86 to CD28 biological functions were also observed. The increased expression of FCGR1A, C8G, C7 and C9 genes and decreasing biological functions in edges from C1R and C1S to C2 and from C1R to C4B, all involved in end-organ damage, were detected. On the other hand, many of subnetworks alterations of TCR and BCR reported in previous research (PI3K/AKT, MAPK, AP-1 transcription factor). Conclusions: Overall, the BNrich as a hybridized network construction method, which integrates intergenic relations inferred from signaling pathways and gene expression profiling, can be employed to study complex diseases. Here we applied BNrich and highlighted significant genes and intergenic relationships and systemic alterations in SLE, TCR and BCR signaling pathways.
Microbial mats in the Turks and Caicos Islands reveal diversity and evolution of phototrophy in the Chloroflexota order Aggregatilineales
Authors: Ward Lewis M , Lingappa Ush , Grotzinger John , Fischer Woodward 
Published: January 2020

Abstract
Genome-resolved metagenomic sequencing approaches have led to a substantial increase in the recognized diversity of microorganisms; this included the discovery of novel metabolic pathways in previously recognized clades, and has enabled a more accurate determination of the extant distribution of key metabolisms and how they evolved over Earth history. Here, we present metagenome-assembled genomes of members of the Chloroflexota (formerly Chloroflexi or Green Nonsulfur Bacteria) order Aggregatilineales (formerly SBR1031 or Thermofonsia) discovered from sequencing of thick and expansive microbial mats present in an intertidal lagoon on Little Ambergris Cay in the Turks and Caicos Islands. These taxa included multiple new lineages of Type 2 reaction center-containing phototrophs that were not closely related to previously described phototrophic Chloroflexota—revealing a rich and intricate history of horizontal gene transfer and the evolution of phototrophy and other core metabolic pathways within this widespread phylum.
Identification of phosphorus stress related proteins in the seedlings of Dongxiang wild rice (Oryza rufipogon Griff.) using label-free quantitative proteomic analysis
Authors: Deng Qianwen , Bai Liweidan , Dai Liangfang , Chen Yaling , Fang Jun , Xie Jiankun , Luo Xiangdong 
Published: January 2020

Abstract
Background: The lack of available phosphorus (P) in soil is one of the important factors restricting rice growth. Previous studies indicated that Dongxiang wild rice (DXWR, O. rufipogon Griff.) was resistant to low-P stress. So far, the research of resistance mechanism in DXWR was very limited.Results: The results showed that 3589 significant differential accumulation proteins were identified between low P and the normal P treated root samples. 60 up-regulated and 15 down-regulated proteins were identified with ≥ 1.5-fold changes as an additional standard. Furthermore, among 75 significantly different expression proteins (SDEPs), 24 proteins also detected in previous transcriptome dataset verified by qRT-PCR, including OsPT2, OsPT8, OsPAP10c, OsPAP10a and OsPHF1. Through comprehensive analysis, it was found that DXWR could increase PAPs, membrane location of PTs, rhizosphere area, alternative splicing and decrease ROS activity to deal with low-P stress. Moreover, among the genes corresponding to 75 SDEPs, 7 uncharacterized genes were located in previous P related QTL intervals, of which two genes (LOC_Os12g09620 and LOC_Os03g40670) have been detected at both transcriptome and proteome levels. In addition, the expression patterns of OsPHR1, OsPHR2, OsPHO1 and NAT-OsPHO1 in DXWR were different in cultivated rice, suggesting that the response mechanism of some low-P tolerance in DXWR might be different from that in cultivated rice.Conclusions: This study screened out some candidate genes for low-P resistance and preliminarily verified that there might be a different low-P response mechanism in DXWR than in cultivated rice, which would provide insights in cloning the P-deficiency genes from wild rice, as well as elucidating the molecular mechanism of low-P resistance in DXWR.
Disequilibrium evolution of Fructose-1,6-bisphosphatase gene family leads to their functional biodiversity in Gossypium species
Authors: Ge Qun , Cūi Yànli , Lǐ Jùnwén , Gōng Jǔwǔ , Lú Quánwěi , Lǐ Péngtāo , Shí Yùzhēn , Shāng Hǎihóng , Liú Àiyīng , Dèng Xiǎoyīng , Pān Jìngtāo , Chén Qúanjiā , Yuán Yǒulù , Gǒng Wànkuí 
Published: January 2020

Abstract
Background：Fructose-1,6-bisphosphatase (FBP) is a key enzyme in plant sucrose synthesis pathway in Calvin cycle and plays an important role in photosynthesis regulation in green plants. However, no systemic analysis of the FBPs has been reported in Gossypium species.Results：A total of 41 FBP genes from four Gossypium species were identified and analyzed. The FBP genes were assorted into two groups and 7 subgroups. The results revealed that FBP family genes were under a purifying selection pressure which rendered FBP family members a conserved evolution pattern and that there was no tandem and fragmental DNA duplication in FBP family genes. Collinearity analysis revealed that a FBP gene was located in the translocated DNA fragment and the whole FBP gene family was under a disequilibrium evolution pattern which led to a faster evolution progress of the members in G. barbadense and in At subgenome than those in the rest Gossypium species and in Dt subgenome, respectively of this study. Through RNA-seq analyses and qRT-PCR verifications, different FBP genes have diversified biological functions in cotton fiber development (2 genes in 0 DPA and 1DPA ovules and 4 genes in 20-25 DPA fibers), and in plant responses to Verticillium wilt onset (2 genes) and to salt stress (8 genes).Conclusion: The FBP gene family displayed disequilibrium evolution pattern in Gossypium species, which render them diversified functions affecting not only fiber development, but also responses to the Verticillium wilt and the salt stress. All the findings provided the foundation for further study of the function of the FBP genes in cotton fiber development and in environmental adaptability.
If you can’t breathe through your nose
Authors: Kalinina N. 
Published: January 2020

According to figures provided by the Ministry of Health, the autumn-winter period is characterized by the prevalence of outbreaks of ARVI and influenza. In case of ARVI of no influenza etiology, the disease develops gradually, it is most often accompanied by cough, and begins with usual fatigue and rhinitis (runny nose), which makes nasal breathing difficult and worsens the patient’s condition. That is why the treatment of rhinitis is an important component of the comprehensive treatment of ARVI and influenza.
Dextran Microparticulate Inhalable Dry Powder for the Treatment of Cystic Fibrosis and Mucopolysaccharidosis
Authors: Solanki Neel R. , Patel Deepa H. , Talele Dipali R. 
Published: January 2020

Background:
Cystic Fibrosis (CF) is a genetic disease which affects the patient’s lungs,
pancreas, liver, kidney and intestine and lacks sulfatase enzyme, leading to mucopolysaccharidosis.
Colistin sulfate acts by interacting with phospholipids of bacterial cell membranes. Sulfatase enzyme
reduces the high levels of sulfated glycosaminoglycans and glycolipids by the hydrolysis of sulfate
esters in lysosome.

Objective:
The aim of the present investigation was to prepare and evaluate dextran microparticulate
inhalable dry powder for the efficient targeting of colistin sulfate at affected area of lung without
causing the side effects in the treatment of CF and mucopolysaccharidosis.

Methods:
Microparticulate dry powder was prepared by the lyophilization method and evaluated for
particle size, % yield, % drug content, solid state characterization, in-vitro lung deposition study, and
in-vitro drug release study.

Results:
Particle size, % yield and % drug content were found to be 4.03 ± 0.196 µm, 94.02 % and
99.45 ± 0.015% respectively. Bulk density, tapped density, hausner’s ratio, carr’s index and angle of
repose of optimized batch were found to be 0.216 ± 0.025 g/cm3, 0.236 ± 0.035 g/cm3, 1.09 ± 0.026,
8.47 ± 0.025 % and 26.10 ± 0.029˚ respectively. A fine particle fraction, fine particle dose, mass median
aerodynamic diameter, geometric standard deviation and emitted dose were found to be 66.78%, 16.45
mg, 4.89 µm, 1.32 and 246.33 mg respectively. The % CDR of optimized batch was found to be 96.12 ±
0.049 % at 24 h.

Conclusion:
Based on the obtained results, we conclude that dextran microparticulate inhalable dry
powder might be suitable carrier for the delivery of colistin sulfate and sulfatase in combination via
pulmonary route for the treatment of cystic fibrosis and mucopolysaccharidosis.
The Prevalence of Vitamin D Deficiency in Iran: A Literature Review
Authors: Bagherniya Mohammad , Khorasanchi Zahra , Bidokhti Mina S. , Ferns Gordon A. , Rezaei Mitra , Ghayour-Mobarhan Majid , Sahebkar Amirhossein 
Published: January 2020

Background:
Vitamin D deficiency is a common medical condition worldwide. In Iran, it
has been reported that between 30-90% of people have vitamin D deficiency. However, its distribution
in different parts of the country and among different age and regional groups is unclear. Therefore,
the aim of this study was to review the recent literature on vitamin D deficiency in Iran.

Methods:
The literature review was performed using Web of Science, PubMed-Medline, Scopus and
Scientific Information Database (SID) with a cut-off date of November 2016 to identify articles on
vitamin D status in Iran published in the last 10 years. Studies in English and Persian that reported
vitamin D levels in male and female subjects of all age groups and in healthy populations were included.

Results:
From 325 studies that were initially retrieved, 82 articles met the inclusion criteria. A high
prevalence of vitamin D deficiency was reported, and in some regions, this was reported as >90%
and was found in all age groups and in all regions of Iran.

Conclusion:
This review highlights the very high prevalence of vitamin D deficiency in Iran. It will
be important to recognize the importance of vitamin D deficiency as a major public health problem in
Iran.
Antiangiogenesis Potential of Alpinumisoflavone as an Inhibitor of Matrix Metalloproteinase-9 (MMP-9) and Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2)
Authors: Alos Honeymae C. , Billones Junie B. , Vasquez Ross D. , Castillo Agnes L. 
Published: January 2020

Background:
Cancer is a very serious public health problem ranking as the second leading
cause of death worldwide. Angiogenesis plays a vital role as a prerequisite for tumor growth and
metastasis, and is indispensable in the further stage advancement of cancer.

Objective:
Targeting several enzymes and receptors in angiogenesis’ signal transduction pathway
will likely offer many more prospects for successful and superior therapeutic intervention.

Method:
Thus, druggable targets in the angiogenesis pathway such as pro-MMP9, MMP-9, EGFR,
VEGF-A, VEGFR-1, VEGFR-2, c-MET kinase, KIT kinase, CSF1R, TIE-2, and RET tyrosine
kinase were the subject of this molecular docking study involving Alpinumisoflavone (AIF), a
multi-targeted natural product with known anticancer activities.

Results:
The results showed that AIF exhibited good binding affinity with all the selected key
angiogenesis promoting proteins with greatest in silico activity in MMP-9 and VEGFR-2. Moreover,
in silico ADMET studies showed that AIF has good intestinal absorption property and solubility, and
very low probability of being carcinogenic, mutagenic, and toxic to embryo or fetus.

Conclusion:
Molecular docking study revealed that Alpinumisoflavone (AIF) could serve as a
promising lead in the development of angiogenesis (multikinase) inhibitor based on its predicted
binding affinity with vital angiogenesis targets.
Design and Analysis of X-OR Gate and 4-Bit Binary to 4-Bit Gray and Gray to Binary Code Converter Using Dual Control Dual SOA TOAD (DCDS-TOAD)
Authors: Maji Kajal , Mukherjee Kousik 
Published: January 2020

Background:
In this paper we have design and analyzed 4-bit binary to 4-bit gray code and
4-bit gray to 4-bit gray code converter using dual control dual semiconductor optical amplifier terahertz
optical asymmetric demultiplexer (DCDS-TOAD). We used control pulse as a Soliton pulse
train. We calculate the extinction ratio, contrast ratio and Q value and found very high values. The
high values of E.R., C.R. and Q value distinguishes the high (‘1’) level to the low(‘0’) very clearly also
shown the variation of E.R., C.R. and Q value with control pulse energy and amplified spontaneous
emission power factor.

Methods:
The basic equations governing the TOAD performance is simulated using MATLAB. The
extinction ratio, contrast ratio and Q value are calculated for analysis of the device.

Results:
Results of operation for the code converters are performed at a bit rate of 100Gbps. The
structure of DCDSTOAD enable us to achieve high values of ER(~ 81dB), CR(~83dB) and Q factor
(86dB). A high Q factor shows very low bit error rate (BER). The eye diagram shows a large eye
opening (REOP~98.5%).

Conclusion:
Design and analyzed 4-bit binary to 4-bit gray code and 4-bit gray to 4-bit gray code
converter using dual control dual semiconductor optical amplifier terahertz optical asymmetric demultiplexer
(DCDS-TOAD) is proposed and analyzed. We used control pulse as a Soliton pulse train. The
proposed X-OR gate finds applications in many devices.
Improvement of Gain Accuracy and CMRR of Low Power Instrumentation Amplifier Using High Gain Operational Amplifiers
Authors: Sahu Rashmi , Konar Maitraiyee , Kundu Sudip 
Published: January 2020

Background:
Sensing of biomedical signals is crucial for monitoring of various health conditions.
These signals have a very low amplitude (in μV) and a small frequency range (<500 Hz). In
the presence of various common-mode interferences, biomedical signals are difficult to detect. Instrumentation
amplifiers (INAs) are usually preferred to detect these signals due to their high commonmode
rejection ratio (CMRR). Gain accuracy and CMRR are two important parameters associated
with any INA. This article, therefore, focuses on the improvement of the gain accuracy and CMRR of
a low power INA topology.

Objective:
The objective of this article is to achieve high gain accuracy and CMRR of low power INA
by having high gain operational amplifiers (Op-Amps), which are the building blocks of the INAs.

Methods:
For the implementation of the Op-Amps and the INAs, the Cadence Virtuoso tool was used.
All the designs and implementation were realized in 0.18 μm CMOS technology.

Results:
Three different Op-Amp topologies namely single-stage differential Op-Amp, folded cascode
Op-Amp, and multi-stage Op-Amp were implemented. Using these Op-Amp topologies separately,
three Op-Amp-based INAs were realized and compared. The INA designed using the high gain multistage
Op-Amp topology of low-frequency gain of 123.89 dB achieves a CMRR of 164.1 dB, with the
INA’s gain accuracy as good as 99%, which is the best when compared to the other two INAs realized
using the other two Op-Amp topologies implemented.

Conclusion:
Using very high gain Op-Amps as the building blocks of the INA improves the gain accuracy
of the INA and enhances the CMRR of the INA. The three Op-Amp-based INA designed with
the multi-stage Op-Amps shows state-of-the-art characteristics as its gain accuracy is 99% and CMRR
is as high as 164.1 dB. The power consumed by this INA is 29.25 μW by operating on a power supply
of ±0.9V. This makes this INA highly suitable for low power measurement applications.
Circular Slotted Antenna with CPW feed for GSM and UWB Applications
Authors: Kumar Sanjeev , Kumar Ravi , Nandan Durgesh 
Published: January 2020

Background & Objective:
The circular slotted monopole microstrip antenna with Coplanar
Waveguide (CPW) feed for unified GSM and Ultra-Wideband (UWB) applications have been
presented in this article. Circular shaped slots have been embedded in the radiating patch. Less surface
area has been found due to slots etching and the overall antenna size is reduced by 45%.

Result:
The proposed antenna demonstrates a double band operation wrapping 883.6-1206 MHz
(GSM band) and 2.75-18.30 GHz (UWB, X, and Ku) frequency band with VSWR of less than 2 and
fractional B. W. of 30.8 % and 147% respectively. The pattern of radiation presented by the antenna
is nearly omnidirectional in H-plane and directional in E-plane within the GSM and UWB band.

Conclusion:
There is a variety of applications nowadays using these UWB antennas such as modern
civil and military applications, wireless and radar communications, etc. Measured results are
presented to validate the proposed antenna structure, which shows that the proposed designed antenna
structure has a stable radiation pattern both at the GSM and UWB band ranges.
Dynamic Feature Extraction Method of Phone Speakers Based on Deep Learning
Authors: Zhang Hongbing 
Published: January 2020

:
Nowadays, speech recognition has become one of the important technologies for human-
computer interaction. Speech recognition is essentially a process of speech training and pattern
recognition, which makes feature extraction technology particularly essential. The quality of
feature extraction is directly related to the accuracy of speech recognition. Dynamic feature parameters
can effectively improve the accuracy of speech recognition. These parameters make the
speech dynamic feature extraction to have a higher research value. The traditional dynamic feature
extraction method is easier to generate more redundant information, resulting in low recognition
accuracy. Therefore, based on a new speech feature extraction method, which is based on deep
learning for speech feature extraction, is proposed in the present study. Firstly, the speech signal is
preprocessed by pre-emphasis, windowing, filtering, and endpoint detection. Then, the sliding differential
cepstral feature (SDC) is extracted, which contains the voice information of the front and
back frames. Finally, the feature is used as input to extract the dynamic features that represent the
depth essence of speech information through the deep self-encoding neural network. The simulation
results show that the dynamic features extracted by in-depth learning have better recognition
performance than the original features, and have a good effect on speech recognition.
Ubi societas, ibi ius? Sobre el lugar del derecho en las teorías clásicas del patrón cultural universal
Authors: Rivaya García Benjamín 
Published: January 2020

No es infrecuente entre los antropólogos entender el Derecho como universal cultural. Que algún rasgo humano sea universal se puede explicar porque es natural, pero el Derecho no es natural. La pregunta entonces es si existen rasgos culturales, no naturales, universales, a lo que los antropólogos suelen responder afirmativamente. La otra pregunta sería la de si el Derecho es un universal cultural, lo que en buena medida depende del concepto de Derecho que utilicemos. No son pocos los antropólogos que, utilizando una perspectiva amplia sobre el Derecho, piensan que sí es un rasgo universal.
“Si el cielo existe, se llama Perú”
Authors: Oliveira Luiz Sérgio De 
Published: January 2020

Resenha da exposição Crónicas Migrantes. Historias comunes entre Perú y Venezuela, realizada pelo / no Museo de Arte Contemporáneo de Lima, Peru, de 12 de setembro de 2019 a 2 de fevereiro de 2020, com curadoria de Fabiola Arroyo. A mostra reuniu obras de mais de 30 artistas peruanos e venezuelanos.
Estado fiscal, tributação e os critérios de justiça no direito tributário
Authors: Difini Luiz Felipe Silveira , Jobim Eduardo De Sampaio Leite 
Published: January 2020

RESUMOO presente artigo visa analisar a tributação no Estado Fiscal sob os critérios de justiça tributária. A análise tradicional da justiça tributária exige que a distribuição do ônus fiscal satisfaça o' critério de igualdade vertical e horizontal, sendo exigência da igualdade – enquanto critério de justiça - que a lei trate de forma igual os iguais e os desiguais de forma diferente de acordo com as suas possibilidades de fazer frente ao ônus fiscal. Vários critérios foram propostos nesse sentido, desde a teoria do benefício até a tributação em perspectiva da capacidade contributiva. Este artigo visa evidenciar como o direito tributário pode ser fundamentado levar em conta os fins de justiça, focando especialmente no princípio da capacidade contributiva e os seus subprincípios.PALAVRAS-CHAVEDireito tributário. Justiça tributária. Princípio do benefício. Capacidade contributiva. ABSTRACTThe present article focuses on the analysis of taxation in the Fiscal State regarding the concepts of tax justice. Traditional analysis of tax justice requires that the distribution of tax burdens meets the criterion of vertical and horizontal equity, and it is a requirement of equity - as a criterion of justice - that like cases should be treated alike and relevantly different cases should be treated differently according to their possibilities to cope with the tax burden. Various criteria for relevant differences have been proposed, drawing on ideas such as ability to pay and taxation in proportion to benefit. This article aims to show how tax law may be founded taking into account goals of justice, focusing especially on the principle of Contributive Capacity and its subprinciples.KEYWORDSTax law. Tax justice. Benefit principle. Contributive Capacity.
El señalamiento del orden de los apellidos de la persona, en el Anteproyecto de Reforma del Código Civil Peruano. Primeras impresiones
Authors: Álvarez César Carranza 
Published: January 2020

RESUMENEn el siguiente texto, el autor analiza el nombre de la persona, con especial atención en la regulación propuesta por el Anteproyecto de Reforma del Código Civil respecto al orden de sus apellidos; valiéndose para ello de las normas vigentes del Código sustantivo, las experiencias del Derecho comparado y los proyectos legislativos del Congreso de la República del Perú sobre el particular.PALABRAS CLAVEDerecho civil. Nombre de la persona. Apellidos de la persona. Anteproyecto de Reforma del Código Civil peruano. Elementos de la personalidad. ABSTRACTIn the following text, the autor analyzes the name of the person, with a focus on the regulation proposed by the Civil Code Reform Project regarding the order of their surnames, relying on existing rules of substantive Code; the experiences of comparative law and legislative projects of the Congress of the Republic of Perú on the subject.KEYWORDSCivil law. Name of the person. Surname of the person. Peruvian Civil Code Reform Project. Elements of personality.