bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contrasting bacterial and archaeal distributions reflecting different geochemical processes in a sediment core from the Pearl River Estuary
Authors: Wang Wenxiu , Tao Jianchang , Liu Haodong , Li Penghui , Chen Songze , Wang Peng , Zhang Chuanlun 
Published: January 2020

AbstractMicrobial community structure and metabolic activities have profound impacts on biogeochemical processes in marine sediments. Functional bacteria such as nitrate- and sulfate-reducing bacteria respond to redox gradients by coupling specific reactions amenable to relevant energy metabolisms. However, similar functional patterns have not been observed for sedimentary archaea (except for anaerobic methanotrophs and methanogens). We coupled taxonomic composition with comprehensive geochemical species to investigate the participation of distinct bacteria and archaea in sedimentary geochemical cycles in a sediment core (300 cm) from Pearl River Estuary (PRE). Geochemical properties (NO3−, dissolved Mn and Fe, SO42+, NH4+; dissolved inorganic carbon (DIC), δ13CDIC, dissolved organic carbon (DOC), total organic carbon (TOC), δ13CTOC, and fluorescent dissolved organic matter (FDOM)) exhibited strong depth variability of different trends. Bacterial 16S rRNA- and dsrB gene abundance decreased sharply with depth while archaeal and bathyarchaeotal 16S rRNA gene copies were relatively constant. This resulted in an increase in relative abundance of archaea from surface (11.6%) to bottom (42.8%). Network analysis showed that bacterial groups of Desulfobacterales, Syntrophobacterales and Gammaproteobacteria were significantly (P < 0.0001) associated with SO42− and dissolved Mn while archaeal groups of Bathyarchaeota, Group C3 and Marine Benthic Group D (MBGD) showed close positive correlations (P < 0.0001) with NH4+, δ13CTOC values and humic-like FDOM. Our study suggested that these bacterial groups dominated in redox processes relevant to sulfate or metal oxides, while the archaeal groups are more like to degrade recalcitrant organic compounds in anaerobic sediments.
Vasopressin and its analogues in shock states: a review
Authors: Demiselle Julien , Fage Nicolas , Radermacher Peter , Asfar Pierre 
Published: January 2020

AbstractActivation of arginine–vasopressin is one of the hormonal responses to face vasodilation-related hypotension. Released from the post-pituitary gland, vasopressin induces vasoconstriction through the activation of V1a receptors located on vascular smooth muscle cells. Due to its non-selective receptor affinity arginine–vasopressin also activates V2 (located on renal tubular cells of collecting ducts) and V1b (located in the anterior pituitary and in the pancreas) receptors, thereby potentially promoting undesired side effects such as anti-diuresis, procoagulant properties due to release of the von Willebrand’s factor and platelet activation. Finally, it also cross-activates oxytocin receptors. During septic shock, vasopressin plasma levels were reported to be lower than expected, and a hypersensitivity to its vasopressor effect is reported in such situation. Terlipressin and selepressin are synthetic vasopressin analogues with a higher affinity for the V1 receptor, and, hence, potentially less side effects. In this narrative review, we present the current knowledge of the rationale, benefits and risks of vasopressin use in the setting of septic shock and vasoplegic shock following cardiac surgery. Clearly, vasopressin administration allows reducing norepinephrine requirements, but so far, no improvement of survival was reported and side effects are frequent, particularly ischaemic events. Finally, we will discuss the current indications for vasopressin and its agonists in the setting of septic shock, and the remaining unresolved questions.
Retraction Note: Existence and uniqueness of solutions for the Schrödinger integrable boundary value problem
Authors: Wang Jianjie , Mai Ali , Wang Hong 
Published: January 2020

The Editors-in-Chief have retracted this article [1] because it shows evidence of peer review manipulation. In addition, it overlaps significantly with an article by Sun et al. [2] that was simultaneously under consideration with another journal. The authors have not responded to any correspondence from the publisher regarding this retraction.
Rectal operative bed: ?tumor? post-management changes … positron emission tomography/computed tomography (PET/CT) can answer
Authors: Abdelmohsen Mohsen Ahmed , Omar Walid Mohamed , Shaaban Ahmed 
Published: January 2020

Abstract
Background
Rectal cancer is a common malignancy that continues to have a highly variable outcome. Local pelvic recurrence following surgery is usually leading to incurable disease. Surgical resection with stage-appropriate combined-modality therapy is the mainstay in the treatment of rectal cancer. A difficulty has been reported in distinguishing the benign post-management findings from tumor recurrence. By adding the metabolic changes to the post-operative morphologic changes, combined positron emission tomography (PET) and computed tomography (CT) may offer clinically useful addition in operative bed evaluation.

Results
The study included 30 patients, 17 males (56.6%) and 13 females (43.3%). Suspicious operative bed findings included pre-sacral soft tissue density noted in 20 patients (66%), anastomotic site mural thickening in five patients (16.6%), and post-operative loco-regional nodes in five patients (16.6%). Moreover, pre-sacral soft tissue focal avid uptake was noted in 17 patients (17/20, 85%), and no uptake noted in three patients (3/20, 15%). Anastomotic site mural thickening was seen in five patients with positive uptake noted in three patients (3/5, 60%), and no uptake seen in two patients (2/5, 40%). Loco-regional nodes were seen in five patients with positive uptake in five patients. The most accurate SUV max cut-off value among studied cases was 3.5. Confirmation of PET/CT results was done by histopathological assessment in ten patients (33.3%) and by follow up after 6 months in 20 patients (66.6%) with recurrence noted in 15 patients (75%) and normal post-operative findings noted in five patients (25%).

Conclusion
PET/CT study is an effective tool for evaluation of suspicious colorectal oncologic operative bed findings noted in the routine CT studies. PET/CT fusion images affect the clinical management by guiding further procedures (surgery and radiation therapy).
In silico QSAR and molecular docking simulation of some novel aryl sulfonamide derivatives as inhibitors of H5N1 influenza A virus subtype
Authors: Abdullahi Mustapha , Shallangwa Gideon Adamu , Uzairu Adamu 
Published: January 2020

Abstract
Background
This research provides a comprehensive analysis of QSAR modeling performed on 25 aryl sulfonamide derivatives to predict their effective concentration (EC50) against H5N1 influenza A virus by using some numerical information derived from structural and chemical features (descriptors) of the compounds to generate a statistically significant model. Subsequently, the molecular docking simulations were done so as to determine the binding modes of some potent ligands in the dataset with the M2 proton channel protein of the H5N1 influenza A virus as the target.

Results
In building the QSAR model, the genetic algorithm task was employed in the variable selection of the descriptors which are used to form the multi-linear regression equation. The model with descriptors, RDF100m, nO, and RDF45p, showed satisfactory internal and external validation parameters (R2train = 0.72963, R2adjusted = 0.67169, Q2cv = 0.598, $$ {R}_{\mathrm{pred}}^2= $$Rpred2= 0.67295, R2test = 0.6860) which passed the model criteria of acceptability. Docking simulation results of the more potent compounds (ligands 2, 3, and 8) revealed the formation of hydrophobic and hydrogen bonds with the binding pockets of M2 protein of influenza A virus.

Conclusion
The results in this study can help to advance the research in designing (in silico design) and synthesis of more potent aryl sulfonamides derivatives against H5N1 influenza virus.
Role of sagittal anorectoplasty in treating constipation in patients with recto-perineal fistula
Authors: Bayoumi Moustafa Mohamed Mahmoud , Allam Ayman Mostafa , AbouZeid Amr Abdelhamid 
Published: January 2020

Abstract
Background
Recto-perineal fistula is a common anorectal anomaly, affecting both males and females. The anus is abnormally anteriorly located and is usually stenotic. Management of recto-perineal fistula is a dialectic problem. The most common presenting complaint is constipation; also, long-term follow-up of these patients revealed high incidence of postoperative constipation.

Results
The study included 30 patients (19 female and 11 male). Their age at time of repair ranged from 3 to 78 months. We compared the pre- and postoperative constipation rate after limited posterior sagittal anorectoplasty (PSARP) using Krickenbeck score. Overall, the rate of constipation has dropped from 77 (23/30) to 30% (9/30) after surgery. Fourteen patients out of 23 patients with preoperative constipation were cured. Another patient with preoperative constipation improved regarding the grade of constipation. The remaining 8 patients with preoperative constipation did not show improvement after operation. These results were statistically significant (McNemar test). Out of the 9 patients who were still constipated after surgery, 7 had associated fecal soiling that showed good response with bowel management of constipation.

Conclusion
Limited posterior sagittal anorectoplasty can have a role in treating constipation among cases of recto-perineal fistula.
Antimullerian Hormone and Impending Menopause in Late Reproductive Age: The Study of Women’s Health Across the Nation
Authors: Finkelstein Joel S , Lee Hang , Karlamangla Arun , Neer Robert M , Sluss Patrick M , Burnett-Bowie Sherri-Ann M , Darakananda Karin , Donahoe Patricia K , Harlow Sioban D , Prizand Sarah H , Joffe Hadine , Kumar Ajay , Martin Deborah E , McConnell Daniel , Merrilat Steffenie , Morrison Anthony , Pastore Lisa M , Randolph John F , Greendale Gail A , Santoro Nanette 
Published: January 2020

Abstract

Background
A test that helps predict the time to the final menstrual period (FMP) has been sought for many years.

Objective
To assess the ability of antimullerian hormone (AMH) measurements to predictions the time to FMP.

Design
Prospective longitudinal cohort study.

Setting
The Study of Women’s Health Across the Nation.

Participants and Measurements
AMH and FSH were measured in 1537 pre- or early perimenopausal women, mean age 47.5 ± 2.6 years at baseline, then serially until 12 months of amenorrhea occurred. AMH was measured using a 2-site ELISA with a detection limit of 1.85 pg/mL.

Main Outcome Measure
Areas under the receiver operating curves (AUC) for AMH-based and FSH-based predictions of time to FMP, stratified by age. Probabilities that women would undergo their FMP in the next 12, 24, or 36 months across a range of AMH values were assessed.

Results
AUCs for predicting that the FMP will occur within the next 24 months were significantly greater for AMH-based than FSH-based models. The probability that a woman with an AMH &lt;10 pg/mL would undergo her FMP within the next 12 months ranged from 51% at h&lt;48 years of age to 79% at ≥51 years. The probability that a woman with an AMH &gt;100 pg/mL would not undergo her FMP within the next 12 months ranged from 97% in women &lt;48 years old to 90% in women ≥51 years old.

Conclusions
AMH measurement helps estimate when a woman will undergo her FMP, and, in general, does so better than FSH.
Lack of AKAP3 disrupts integrity of the subcellular structure and proteome of mouse sperm and causes male sterility
Authors: Xu Kaibiao , Yang Lele , Zhang Lan , Qi Huayu 
Published: January 2020

ABSTRACT
The development and maintenance of the correct morphology of sperm is important for their functions. Cellular morphogenesis of sperm occurs during the post-meiotic developmental stage; however, little is known about what coordinates this process. In the present study, we investigated the role of A-kinase anchoring protein 3 (AKAP3) during mouse spermiogenesis, using both mouse genetics and proteomics. It was found that AKAP3 is essential for the formation of the specific subcellular structure of the sperm flagellum, motility of sperm and male fertility. Additionally, lack of AKAP3 caused global changes of the sperm proteome and mislocalization of sperm proteins, including accumulation of RNA metabolism and translation factors and displacement of PKA subunits in mature sperm, which may underlie misregulated PKA activity and immotility in sperm. Interestingly, sperm lacking a complete fibrous sheath from both Akap3 and Akap4 null mice accumulated F-actin filaments and morphological defects during post-testicular maturation in the epididymis. These results suggest that the subcellular structures of sperm could be formed via independent pathways, and elucidate the roles of AKAP3 during the coordinated synthesis and organization of the sperm proteome and sperm morphology.
A design principle for floral organ number and arrangement in flowers with bilateral symmetry
Authors: Nakagawa Aiko , Kitazawa Miho S. , Fujimoto Koichi 
Published: January 2020

ABSTRACT
The bilateral symmetry of flowers is a striking morphological achievement during floral evolution, providing high adaptation potential for pollinators. The symmetry can appear when floral organ primordia developmentally initiate. Primordia initiation at the ventral and dorsal sides of the floral bud is differentially regulated by several factors, including external organs of the flower and CYCLOIDEA (CYC) gene homologues, which are expressed asymmetrically on the dorso-ventral axis. It remains unclear how these factors control the diversity in the number and bilateral arrangement of floral organs. Here, we propose a mathematical model demonstrating that the relative strength of the dorsal-to-ventral inhibitions and the size of the floral stem cell region (meristem) determines the number and positions of the sepal and petal primordia. The simulations reproduced the diversity of monocots and eudicots, including snapdragon Antirrhinum majus and its cyc mutant, with respect to organ number, arrangement and initiation patterns, which were dependent on the inhibition strength. These theoretical results suggest that diversity in floral symmetry is primarily regulated by the dorso-ventral inhibitory field and meristem size during developmental evolution.
The Conditional Capital Asset Pricing Model Revisited: Evidence from High-Frequency Betas
Authors: Hollstein Fabian , Prokopczuk Marcel , Wese Simen Chardin 
Published: January 2020

When using high-frequency data, the conditional capital asset pricing model (CAPM) can explain asset-pricing anomalies. Using conditional betas based on daily data, the model works reasonably well for a recent sample period. However, it fails to explain the size anomaly as well as three out of six of the anomaly component excess returns. Using high-frequency betas, the conditional CAPM is able to explain the size, value, and momentum anomalies. We further show that high-frequency betas provide more accurate predictions of future betas than those based on daily data. This result holds for both the time-series and the cross-sectional dimensions. This paper was accepted by Karl Diether, finance.
The Establishment of an Intravenous Conscious Sedation Service for Adult Patients in a Primary Dental Care Setting
Authors: Binnie Rebecca SL , Robb Nigel D , Manton Sarah L , Bonsor Stephen J 
Published: January 2020

Dental anxiety is common within the population and can detrimentally affect the delivery of dental care for those patients affected. Non-pharmacological-based behaviour management techniques are available to the clinician but may not be sufficient or applicable for every patient. In such cases, intravenous conscious sedation with midazolam has been demonstrated to be safe, effective and well tolerated. The present article reviews the criteria and guidance which must be addressed by the dental team when establishing an intravenous conscious sedation service in a primary dental care setting.CPD/Clinical Relevance: General dental practitioners may wish to consider establishing a conscious sedation service in their practices to facilitate the care of nervous patients or those undergoing prolonged, unpleasant treatments such as surgical procedures. The present paper aims to highlight the considerations which require to be addressed in order to establish such a service for adult patients using intravenous midazolam.
Polarization-coded material classification in automotive LIDAR aiming at safer autonomous driving implementations
Authors: Nunes-Pereira E. J. , Peixoto H. , Teixeira J. , Santos J. 
Published: January 2020

LIDAR sensors are one of the key enabling technologies for the wide acceptance of autonomous driving implementations. Target identification is a requisite in image processing, informing decision making in complex scenarios. The polarization from the backscattered signal provides an unambiguous signature for common metallic car paints and can serve as one-point measurement for target classification. This provides additional redundant information for sensor fusion and greatly alleviates hardware requirements for intensive morphological image processing. Industry decision makers should consider polarization-coded LIDAR implementations. Governmental policy makers should consider maximizing the potential for polarization-coded material classification by enforcing appropriate regulatory legislation. Both initiatives will contribute to faster (safer, cheaper, and more widely available) advanced driver-assistance systems and autonomous functions. Polarization-coded material classification in automotive applications stems from the characteristic signature of the source of LIDAR backscattering: specular components preserve the degree of polarization while diffuse contributions are predominantly depolarizing.
Membrane-free acoustic sensing based on an optical fiber Mach–Zehnder interferometer
Authors: Zhu Wenhua , Li Danyang , Liu Jiaojiao , Wang Ruohui 
Published: January 2020

Traditional optical fiber acoustic sensors are mostly based on mechanical diaphragms and use indirect coupling between the acoustic and optical signals. The detectable frequency range and sound pressure range of such a sensor have limitations because they are influenced by the membrane or a mechanically deformable material. In this paper, a Mach–Zehnder interferometer-based membrane-free acoustic sensing method is developed. The sensing principle relies on direct detection of sound-pressure-induced changes of the refractive index in the open cavity. This enables an inherently flat frequency response over a broad bandwidth. Simulation and experiment were carried out to verify and demonstrate the idea. The results show that the membrane-free acoustic sensor has a flat frequency response from 500 Hz to 20 kHz.
Simple approach for Doppler frequency shift estimation based on a dual-polarization quadrature phase shift keying (DP-QPSK) modulator
Authors: Li Jinye , Yu Wenqi , Zhang Zhike , Lin Tao , Dai Shuangxing , Liu Jianguo 
Published: January 2020

A simple approach to estimating microwave Doppler frequency shift (DFS) based on a single dual-polarization quadrature phase shift keying (DP-QPSK) modulator is proposed and experimentally demonstrated. The scheme is capable of estimating both the value and direction of the DFS simultaneously and precisely owing to the introduction of the reference signal. In the proposed approach, the transmitted signal (microwave carrier) and the reference signal are loaded on the upper branch of the DP-QPSK modulator to generate carrier suppression double-sideband signals, respectively, while the echo signal is loaded on the lower branch of the DP-QPSK modulator to perform carrier suppression single-sideband modulation. Then optical sidebands of two branches are combined and sent to a low-speed photodetector to heterodyne. The value of the DFS is equivalent to the frequency of the beat signal between the transmitted and reference signals; meanwhile, the direction can be distinguished by comparing the frequency of the beat signal between the transmitted and reference signals with the frequency of the beat signal between the echo and reference signals. In the experiment, the accurate measurement of DFSs from

−

100

k
H
z

to

+

100

k
H
z

at the carrier frequencies of 15, 20, 35, and 39 GHz is implemented with errors less than

±

10

H
z

.
Three-degree-of-freedom autocollimator based on a combined target reflector
Authors: Guo Yan , Cheng Haobo , Wen Yongfu , Feng Yunpeng 
Published: January 2020

As an angle measuring instrument, the traditional autocollimator has the ability to measure the two-degree-of-freedom angles, namely, pitch and yaw, but fails to measure the roll angle. In this study, we propose a novel autocollimator that can simultaneously measure the three-degree-of-freedom (3-DOF) angles. As a key component, a combined target reflector (CTR) is meticulously designed to split the collimated laser beam into two beams. The 3-DOF angle measurement is achieved by sensing the displacements of the two beam spots reflected from the CTR. The measurement principle and simulation analysis are presented in detail. Experiments are conducted to assess the performance of the proposed autocollimator, and the results indicate that it has an accuracy of better than 0.74 arcsec over a range of

±
200

a
r
c
s
e
c

, and it can be used for 3-DOF angular motion error measurement of a precision displacement stage.
Photonic instantaneous microwave frequency measurement with adjustable measurement range based on an electro-optical polarization modulator
Authors: Guo Yanting , Ma Jianxin 
Published: January 2020

This paper presents a simple photonic-assisted instantaneous microwave frequency measurement approach with an adjustable measurement range. In our scheme, different polarization processing is performed on the upper and the lower branches, and then the powers of the two branches are compared to obtain the amplitude comparison function (ACF), which provides the frequency-amplitude mapping. The measurement system is significantly simplified since only one polarization modulator (PolM) and one single laser source are required. In addition, our scheme achieves a larger ACF slope, which significantly increases the measurement resolution. In the simulation, a frequency measurement over the range of 3–42.8 GHz with measurement errors within

±
0.1

G
H
z

is achieved by optimizing the dc bias voltage applied to the PolM and the polarization angle. This scheme provides a reference for measuring the unknown instantaneous frequency of the received signal from a radar system.
Laser-driven optothermal microactuator operated in water
Authors: You Qingyang , Wang Yingda , Zhang Ziyao , Zhang Haijun , Tsuchiya Toshiyuki , Tabata Osamu 
Published: January 2020

This paper proposes and studies the characteristics of a laser-driven optothermal microactuator (OTMA) directly operated in water. A theoretical model of optothermal temperature rise and expansion is established, and simulations on a 1000 µm long OTMA are conducted, revealing that its arm is able to expand and contract in response to the laser pulses in a water environment. Microactuating experiments are further carried out using a microfabricated OTMA. The results demonstrate that the OTMA can be practically actuated in water by a 650 nm laser beam and that the OTMA’s deflection amplitude increases linearly with laser power. When irradiated by laser pulses with 9.9 mW power and 0.9–25.6 Hz frequencies, the OTMA achieves deflection amplitude ranging from 3.9 to 3.2 µm, respectively. The experimental results match well with theoretical model when taking the damping effect of water into account. This research may be conducive to developing particular micro-electromechanical systems or micro-optoelectromechanical devices such as underwater optothermal micromotors, micro-pumps, micro-robots, and other underwater microactuators.