bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Longitudinal Analysis of Nurse Suicide in the United States (2005–2016) With Recommendations for Action
Authors: Davidson Judy E. , Proudfoot James , Lee Kelly , Terterian Garni , Zisook Sidney 
Published: February 2020

AbstractBackgroundPrevious studies have demonstrated nurses are at risk of suicide. This is the first national longitudinal study of U.S. nurse suicide.AimsTo identify the longitudinal incidence, method, and risks of nurse suicide in the United States.Methods2005 to 2016 Centers for Disease Control and Prevention National Violent Death Reporting System retrospective analysis of suicide incident rate ratios (IRR).ResultsA total of 1,824 nurse and 152,495 non‐nurse suicides were evaluated. Nurses were at greater risk of suicide than the general population (female IRR 1.395, 95% confidence intervals [CI] 1.323, 1.470, p < .001; male IRR 1.205, 95% CI 1.083, 1.338, p < .001). Female nurses who completed suicide did so most frequently by pharmacologic poisoning (n = 399, 27.2% vs. n = 8,843, 26.9%), whereby male nurses and the general public used firearms (n = 148, 41.7% vs. n = 57,887, 48.4%). Job problems were more likely in nurses (female odds ratio [OR] 1.989, 95% CI 1.695, 2.325, p < .001; male OR 1.814, 95% CI 1.380, 2.359, p < .001), as well as mental health history (female OR 1.126, 95% CI 1.013, 1.253, p < .027; male OR 1.302, 95% CI 1.048, 1.614, p = .016) and leaving a suicide note (female OR 1.221, 95% CI 1.096, 1.360, p < .001; male OR 1.756 [1.412, 2.181], p < .001).Linking Evidence to ActionThe increased risk of suicide in nurses is congruent with previous reports. The consistency in results increases confidence that findings are generalizable and warrant action. The use of pharmacologic poisoning as a method of suicide, most often by opioids and benzodiazepines, indicates a need for improved identification and treatment of nurses with substance use. Workplace wellness programs need to focus on reducing workplace stressors. Further research is indicated to determine best prevention methods. Policy indications include the need to accurately track gender in nursing, enhance substance use disorder programs, and mandate suicide prevention activities.
Thermal Model of a Solar Thermochemical Reactor for Metal Oxide Reduction
Authors: Wang Bo , Li Lifeng , Pottas Johannes J. , Bader Roman , Kreider Peter B. , Wheeler Vincent M. , Lipiński Wojciech 
Published: February 2020

Abstract
A transient heat transfer model is developed to study the thermal performance of a high-temperature solar thermochemical reactor for metal oxide reduction. The solar reactor consists of an indirectly irradiated tubular fluidized bed contained in a solar cavity receiver. Radiative heat transfer in the cavity, modeled with the Monte Carlo ray-tracing method, is coupled to conduction in the tube and cavity walls. Incident radiation distributions from a diffuse radiative source and a high-flux solar simulator are implemented separately in the model to study the influence of incident radiation directionality on the performance of the reactor. Maximum temperature, maximum thermal stress, start-up time, energy balance, and particle reduction rate for the proposed reactor concept are calculated to inform the design and optimization of a prototype reactor.
Historic cohort: outcome of chronic exertional compartment syndrome-suspected patients
Authors: Maksymiak Roy , Ritchie E , Zimmermann W , Maliko N , van der Werve M , Verschure M , Hoencamp R 
Published: February 2020

IntroductionExercise-related leg pain (ERLP) may be caused by chronic exertional compartment syndrome (CECS), occurring mainly in athletes and military recruits. In military populations, the effectiveness of surgical treatment in CECS is debated. The purpose of this study is to assess the outcome of surgical treatment for CECS in Alrijne Hospital (the Netherlands), a civilian hospital with supraregional referral function.MethodsA historic cohort study was performed on patients with ERLP who were suspected for CECS and were referred for intracompartmental pressure measurement (ICPM) from 2013 to 2017 (n=160). Patient demographics, ICPM and survey response were analysed.ResultsThe mean delay before visitation was 29.0±30.3 months. When comparing surgical-treated patients with CECS with conservative-treated patients with ERLP, surgical-treated patients were more satisfied, reported better recovery towards former level of performance (2.8±2.0 vs 3.9±1.7 and 2.5±1.6 vs 3.2±1.4 on a 7-point Likert scale, respectively) and better subjective injury status (79.3±22.6 vs 63.5±27.4 using the Single Assessment Numeric Evaluation score). Treatment satisfaction was 75.0% in surgical-treated CECS versus 51.4% in conservative-treated ERLP.ConclusionCivilian patients report improved functional outcomes after fasciotomy for CECS. Future research should focus on non-invasive diagnostic options and methods to determine which treatment is the most appropriate for each individual patient.
Interactions of sprint interval exercise and psychological need-support on subsequent food intake among physically inactive men and women
Authors: Beer Natalya J. , Dimmock James A. , Jackson Ben , Guelfi Kym J. 
Published: February 2020

The aim of this study was to investigate the effect of sprint interval training (SIT) and psychological need-support in exercise on postexercise appetite and energy intake. Forty physically inactive men and women (body mass index, 24.6 ± 4.8 kg·m−2; peak oxygen consumption, 26.6 ± 4.9 mL·kg−1·min−1) were randomised to either a need-support or no-support condition, with each participant completing 2 experimental trials involving 30 min of moderate-intensity continuous training (MICT; 60% peak oxygen consumption) and SIT (alternating 15 s at 170% peak oxygen consumption and 60 s at 32% peak oxygen consumption) matched for total work. Perceptions of appetite and appetite-related blood variables were assessed, together with ad libitum energy intake for 3 h following exercise using a laboratory test meal and available snacks. Greater enjoyment, perceived exertion, heart rate, and blood lactate were observed in SIT compared with MICT (all p ≤ 0.006). Ratings of perceived appetite were similar across conditions and trials (p > 0.05); however, active ghrelin was lower following SIT compared with MICT (p < 0.001), and there was a significant condition-by-type interaction for energy intake (p = 0.033), with participants in the support group consuming less energy from foods following SIT (1895 ± 1040 kJ) than MICT (2475 ± 1192 kJ). Findings from this work highlight the need to reconsider traditional exercise guidelines where dietary intake is a concern. Novelty Enjoyment was greater during SIT compared with MICT. Enjoyment and choice were higher among participants provided with psychological need-support. In a need-supportive environment, SIT reduced subsequent energy intake compared with MICT.
Fluctuations and clustering of multiplicity in collisions of relativistic ions
Authors: Rybczyński Maciej , Włodarczyk Zbigniew 
Published: February 2020

AbstractWe discuss the recently measured event-by-event multiplicity fluctuations in relativistic heavy-ion collisions. It is shown that the observed non-monotonic behavior of the scaled variance of the multiplicity distribution as a function of collision centrality can be fully explained by the correlations between produced particles promoting cluster formation (such an effect is not observed in a widely used string-hadronic models of nuclear collisions). We define a cluster as a quasi-neutral gas of charged and neutral particles which exhibits collective behavior. The characteristic space scale of this shielding is the Debye length. The multiplicity distribution in a cluster is given by a negative binomial distribution while the rest (reservoir), treated as a superposition of elementary collisions, is described by a binomial distribution. The ability to generate spatial structures (cluster phase) with self-similar fluctuations of multiplicity sign the propensity to self-organize of hadronic matter.
Vacuum instability in a constant inhomogeneous electric field: a new example of exact nonperturbative calculations
Authors: Adorno T. C. , Gavrilov S. P. , Gitman D. M. 
Published: February 2020

AbstractBasic quantum processes (such as particle creation, reflection, and transmission on the corresponding Klein steps) caused by inverse-square electric fields are calculated. These results represent a new example of exact nonperturbative calculations in the framework of QED. The inverse-square electric field is time-independent, inhomogeneous in the x -direction, and is inversely proportional to x squared. We find exact solutions of the Dirac and Klein–Gordon equations with such a field and construct corresponding in- and out-states. With the help of these states and using the techniques developed in the framework of QED with x-electric potential steps, we calculate characteristics of the vacuum instability, such as differential and total mean numbers of particles created from the vacuum and vacuum-to-vacuum transition probabilities. We study the vacuum instability for two particular backgrounds: for fields widely stretches over the x-axis (small-gradient configuration) and for the fields sharply concentrates near the origin $$x=0$$x=0 (sharp-gradient configuration). We compare exact results with ones calculated numerically. Finally, we consider the electric field configuration, composed by inverse-square fields and by an x-independent electric field between them to study the role of growing and decaying processes in the vacuum instability.
Tunable optical absorption of WS2monolayer via alkali metal modulation
Authors: Wu Pengfei , Cui Zhen , Wang Xinmei , Ding Yingchun 
Published: February 2020

The electronic and optical absorption behaviors of alkali-metal atoms doped WS2monolayer were systematically investigated by employing density functional theory based on first-principles calculations. The observed all alkali-metal-doped WS2monolayer present metal behaviors, whereas the intrinsic WS2monolayer exhibits semiconductor behavior. Charge density difference demonstrates that the large charge transfer occurs between the alkali metal and WS2layer. The work function of WS2can be adjusted from 5.12 eV to 5.52 eV. Importantly, the absorption spectrums of alkali-metal-doped WS2appear with some absorption peaks at the 405 nm, 512 nm and 575 nm in the visible light range, which demonstrate the alkali-metal-doped WS2can be used for photovoltaic and visible photocatalytic devices. Furthermore, the absorption spectrum of WS2is generally redshifted through alkali metal doping. This indicates that alkali metal doping can broaden its application in optoelectronic devices.
Analysis of current–voltage and capacitance–voltage characteristics of Zr/p-Si Schottky diode with high series resistance
Authors: Aldemir Durmuş Ali 
Published: February 2020

Zr/p-Si Schottky diode was fabricated by DC magnetic sputtering of Zr on p-Si. Zr rectifying contact gave a zero bias barrier height of 0.73 eV and an ideality factor of 1.33 by current–voltage measurement. The experimental zero bias barrier height was higher than the value predicted by metal-induced gap states (MIGSs) and electronegativity theory. The forward bias current was limited by high series resistance. The series resistance value of 9840 [Formula: see text] was determined from Cheung functions. High value of the series resistance was ascribed to low quality ohmic contact. In addition to Cheung functions, important contact parameters such as barrier height and series resistance were calculated by using modified Norde method. Re-evaluation of modified Norde functions was realized in the direction of the method proposed by Lien et al. [IEEE Trans. Electron Devices 31 (1984) 1502]. From the method, the series resistance and ideality factor values were found to be as 41.49 [Formula: see text] and 2.08, respectively. The capacitance–voltage characteristics of the diode were measured as a function of frequency. For a wide range of applied frequency, the contact parameters calculated from [Formula: see text]–[Formula: see text] curves did not exhibit frequency dependence. The barrier height value of 0.71 eV which was in close agreement with the value of zero bias barrier height was calculated from [Formula: see text]–[Formula: see text] plot at 1 MHz. The values of acceptor concentration obtained from [Formula: see text]–[Formula: see text] curves showed consistency with actual acceptor concentration of p-Si.
From biquandle structures to Hom-biquandles
Authors: Horvat E. , Crans A. S. 
Published: February 2020

We investigate the relationship between the quandle and biquandle coloring invariant and obtain an enhancement of the quandle and biquandle coloring invariants using biquandle structures. We also continue the study of biquandle homomorphisms into a medial biquandle begun in [Hom quandles, J. Knot Theory Ramifications 23(2) (2014)], finding biquandle analogs of results therein. We describe the biquandle structure of the Hom-biquandle, and consider the relationship between the Hom-quandle and Hom-biquandle.
Tumor Mutational Burden and PTEN Alterations as Molecular Correlates of Response to PD-1/L1 Blockade in Metastatic Triple-Negative Breast Cancer
Authors: Barroso-Sousa Romualdo , Keenan Tanya E. , Pernas Sonia , Exman Pedro , Jain Esha , Garrido-Castro Ana C. , Hughes Melissa , Bychkovsky Brittany , Umeton Renato , Files Janet L. , Lindeman Neal I. , MacConaill Laura E. , Hodi F. Stephen , Krop Ian E. , Dillon Deborah , Winer Eric P. , Wagle Nikhil , Lin Nancy U. , Mittendorf Elizabeth A. , Van Allen Eliezer M. , Tolaney Sara M. 
Published: February 2020

Abstract

Purpose:
Few patients with metastatic triple-negative breast cancer (mTNBC) benefit from immune checkpoint inhibitors (ICI). On the basis of immunotherapy response correlates in other cancers, we evaluated whether high tumor mutational burden (TMB) ≥10 nonsynonymous mutations/megabase and PTEN alterations, defined as nonsynonymous mutations or 1 or 2 copy deletions, were associated with clinical benefit to anti-PD-1/L1 therapy in mTNBC.

Experimental Design:
We identified patients with mTNBC, who consented to targeted DNA sequencing and were treated with ICIs on clinical trials between April 2014 and January 2019 at Dana-Farber Cancer Institute (Boston, MA). Objective response rate (ORR), progression-free survival (PFS), and overall survival (OS) were correlated with tumor genomic features.

Results:
Sixty-two women received anti-PD-1/L1 inhibitors alone (23%) or combined with targeted therapy (19%) or chemotherapy (58%). High TMB (18%) was associated with significantly longer PFS (12.5 vs. 3.7 months; P = 0.04), while PTEN alterations (29%) were associated with significantly lower ORR (6% vs. 48%; P = 0.01), shorter PFS (2.3 vs. 6.1 months; P = 0.01), and shorter OS (9.7 vs. 20.5 months; P = 0.02). Multivariate analyses confirmed that these associations were independent of performance status, prior lines of therapy, therapy regimen, and visceral metastases. The survival associations were additionally independent of PD-L1 in patients with known PD-L1 and were not found in mTNBC cohorts treated with chemotherapy (n = 90) and non-ICI regimens (n = 169).

Conclusions:
Among patients with mTNBC treated with anti-PD-1/L1 therapies, high TMB and PTEN alterations were associated with longer and shorter survival, respectively. These observations warrant validation in larger datasets.
Persistent Asthma Is Associated With Increased Risk for Incident Atrial Fibrillation in the MESA
Authors: Tattersall Matthew C. , Dasiewicz Alison S. , McClelland Robyn L. , Gepner Adam D. , Kalscheur Matthew M. , Field Michael E. , Heckbert Susan R. , Hamdan Mohamed H. , Stein James H. 
Published: February 2020

Background:
Asthma and atrial fibrillation (AF) share an underlying inflammatory pathophysiology. We hypothesized that persistent asthmatics are at higher risk for developing AF and that this association would be attenuated by adjustment for baseline markers of systemic inflammation.

Methods:
The MESA (Multi-Ethnic Study of Atherosclerosis) is a prospective longitudinal study of adults free of cardiovascular disease at baseline. Presence of asthma was determined at exam 1. Persistent asthma was defined as asthma requiring use of controller medications. Intermittent asthma was defined as asthma without use of controller medications. Participants were followed for a median of 12.9 (interquartile range, 10–13.6) years for incident AF. Multivariable Cox regression models were used to assess associations of asthma subtype and AF.

Results:

The 6615 participants were a mean (SD) 62.0 (10.2) years old (47% male, 27% black, 12% Chinese, and 22% Hispanic). AF incidence rates were 0.11 (95% CI, 0.01–0.12) events/10 person-years for nonasthmatics, 0.11 (95% CI, 0.08–0.14) events/10 person-years for intermittent asthmatics, and 0.19 (95% CI, 0.120.49) events/10 person-years for persistent asthmatics (log-rank
P
=0.008). In risk-factor adjusted models, persistent asthmatics had a greater risk of incident AF (hazard ratio, 1.49 [95% CI, 1.03–2.14],
P
=0.03). IL (Interleukin)-6 (hazard ratio, 1.26 [95% CI, 1.13–1.42]), TNF (tumor necrosis factor)-α receptor 1 (hazard ratio, 1.09 [95% CI, 1.08–1.11]) and D-dimer (hazard ratio, 1.10 [95% CI, 1.02–1.20]) predicted incident AF, but the relationship between asthma and incident AF was not attenuated by adjustment for any inflammation marker (IL-6, CRP [C-reactive protein], TNF-α R1, D-dimer, and fibrinogen).

Conclusions:
In a large multiethnic cohort with nearly 13 years follow-up, persistent asthma was associated with increased risk for incident AF. This association was not attenuated by adjustment for baseline inflammatory biomarkers.
Measuring Cognitive Flexibility with the Flexible Item Selection Task: From fMRI Adaptation to Individual Connectome Mapping
Authors: Dajani Dina R. , Odriozola Paola , Winters Melanie , Voorhies Willa , Marcano Selene , Baez Adriana , Gates Kathleen M. , Dick Anthony Steven , Uddin Lucina Q. 
Published: February 2020

Abstract
Cognitive flexibility, the ability to appropriately adjust behavior in a changing environment, has been challenging to operationalize and validate in cognitive neuroscience studies. Here, we investigate neural activation and directed functional connectivity underlying cognitive flexibility using an fMRI-adapted version of the Flexible Item Selection Task (FIST) in adults (n = 32, ages 19–46 years). The fMRI-adapted FIST was reliable, showed comparable performance to the computer-based version of the task, and produced robust activation in frontoparietal, anterior cingulate, insular, and subcortical regions. During flexibility trials, participants directly engaged the left inferior frontal junction, which influenced activity in other cortical and subcortical regions. The strength of intrinsic functional connectivity between select brain regions was related to individual differences in performance on the FIST, but there was also significant individual variability in functional network topography supporting cognitive flexibility. Taken together, these results suggest that the FIST is a valid measure of cognitive flexibility, which relies on computations within a broad corticosubcortical network driven by inferior frontal junction engagement.
Brain Regions Involved in Conceptual Retrieval in Sighted and Blind People
Authors: Bottini Roberto , Ferraro Stefania , Nigri Anna , Cuccarini Valeria , Bruzzone Maria Grazia , Collignon Olivier 
Published: February 2020

Abstract
If conceptual retrieval is partially based on the simulation of sensorimotor experience, people with a different sensorimotor experience, such as congenitally blind people, should retrieve concepts in a different way. However, studies investigating the neural basis of several conceptual domains (e.g., actions, objects, places) have shown a very limited impact of early visual deprivation. We approached this problem by investigating brain regions that encode the perceptual similarity of action and color concepts evoked by spoken words in sighted and congenitally blind people. At first, and in line with previous findings, a contrast between action and color concepts (independently of their perceptual similarity) revealed similar activations in sighted and blind people for action concepts and partially different activations for color concepts, but outside visual areas. On the other hand, adaptation analyses based on subjective ratings of perceptual similarity showed compelling differences across groups. Perceptually similar colors and actions induced adaptation in the posterior occipital cortex of sighted people only, overlapping with regions known to represent low-level visual features of those perceptual domains. Early-blind people instead showed a stronger adaptation for perceptually similar concepts in temporal regions, arguably indexing higher reliance on a lexical-semantic code to represent perceptual knowledge. Overall, our results show that visual deprivation does changes the neural bases of conceptual retrieval, but mostly at specific levels of representation supporting perceptual similarity discrimination, reconciling apparently contrasting findings in the field.
Theta Phase-dependent Modulation of Perception by Concurrent Transcranial Alternating Current Stimulation and Periodic Visual Stimulation
Authors: Somer Elif , Allen John , Brooks Joseph L. , Buttrill Vaughan , Javadi Amir-Homayoun 
Published: February 2020

Abstract
Sensory perception can be modulated by the phase of neural oscillations, especially in the theta and alpha ranges. Oscillatory activity in the visual cortex can be entrained by transcranial alternating current stimulation (tACS) as well as periodic visual stimulation (i.e., flicker). Combined tACS and visual flicker stimulation modulates BOLD response, and concurrent 4-Hz auditory click train, and tACS modulate auditory perception in a phase-dependent way. In this study, we investigated whether phase synchrony between concurrent tACS and periodic visual stimulation (i.e., flicker) can modulate performance on a visual matching task. Participants completed a visual matching task on a flickering visual stimulus while receiving either in-phase (0°) or asynchronous (180°, 90°, or 270°) tACS at alpha or theta frequency. Stimulation was applied over either occipital cortex or dorsolateral pFC. Visual performance was significantly better during theta frequency tACS over the visual cortex when it was in-phase (0°) with visual stimulus flicker, compared with antiphase (180°). This effect did not appear with alpha frequency flicker or with dorsolateral pFC stimulation. Furthermore, a control sham group showed no effect. There were no significant performance differences among the asynchronous (180°, 90°, and 270°) phase conditions. Extending previous studies on visual and auditory perception, our results support a crucial role of oscillatory phase in sensory perception and demonstrate a behaviorally relevant combination of visual flicker and tACS. The spatial and frequency specificity of our results have implications for research on the functional organization of perception.