bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long Wavelength Single Photon Like Driven Photolysis Via Triplet-Triplet Annihilation
Authors: Han Gang , Huang Ling , Zeng Le , Chen Yongzhi , Yu Nuo , Wang Lei , Huang Kai , Zhao Yang 
Published: September 2020

Abstract
Photolysis has enabled the occurrence of numerous discoveries in chemistry, drug discovery and biology. However, there is a dearth of efficient long wavelength light mediated photolysis. Here, we report general and efficient long wavelength single photon method for a wide array of photolytic molecules via triplet-triplet annihilation photolysis (TTAP). This method is versatile and "LEGO"-like. The light partners (the photosensitizers and the photolytic molecules (PPG-Xs)) can be energetically matched to adapt to an extensive range of electromagnetic spectrum wavelengths and the diversified chemical structures of photoremovable protecting groups (PPGs), photolabile linkages, as well as a broad array of targeted molecules. Our TTAP not only surpasses reaction yields, it also resolves the photodamage problem of the existing photolysis methods, regardless of whether they are a single photon or multiple photons associated. Furthermore, we developed ambient air-stable, TTAP nanoparticles to illustrate the biological promise of TTAP “LEGO” systems.
High carrier prevalence with poor knowledge of thalassaemia among the university students from indigenous communities in Bangladesh
Authors: Hasan Md. Mahbub , U Khaza Md. Kapil , Lokman Syed Mohammad , Mannan Adnan , Raheem Enayetur , Chowdhury Shahed Ahmad , Hossain Mohammad Sorowar 
Published: September 2020

Abstract
Background

Thalassemia is an inherited life-threatening but preventable haemoglobin disorder. South Asian countries including Bangladesh are the hotspots of world’s thalassemia belt. Indigenous communities are underprivileged and vulnerable to genetic disorders including thalassaemia. Understanding the perspectives of thalassemia of the future community leaders (indigenous university students) is critical for developing a tailor-made preventive strategy relevant to their communities. In this study, we aimed to assess the level of knowledge and attitudes towards thalassaemia among indigenous university students and determine their thalassemia carrier status.
Methods

A cross-sectional survey was conducted among 251 tribal university students using a published questionnaire between May and October 2018. Half of the students underwent thalassemia carrier screening by haemoglobin electrophoresis. Descriptive and inferential statistical procedures were used for data analysis.
Results

More than half (55%) of the indigenous students had never heard the term 'thalassaemia'. Around half of the marriages in their communities were consanguineous. The mean knowledge score was very poor (4.91 ± 2.65) which was not associated study disciplines, and year of study. Nearly 39% of the students were found to be the carrier of E trait, while 1.8% of them had beta trait and 7% E disease. Thalassaemia carrier status was not significantly correlated with sex, ethnicity, or home districts.
Conclusions

For the first time, this study has identified knowledge gaps and misperceptions about thalassaemia among university students from indigenous communities with a higher prevalence of thalassaemia. This study serves as a baseline for future interventions (premarital and prenatal screening) targeting future community leaders.
Ligand Based 3D-QSAR Pharmacophore, Molecular Docking and Adme to Identify Potential Fibroblast Growth Factor Receptor 1 Inhibitors&nbsp;
Authors: Tang Zizhong , Huang Lu , Fu Xiaoli , Wang Haoxiang , Tang Biao , Xiao Yirong , Zhou Caixia , Zhao Zhiqiao , Wan Yujun , Chen Hui , Yao Huipeng , Shan Zhi , Bu Tongliang , Wu Xulong 
Published: September 2020

Abstract
The FGF/FGFR system may affect tumor cells and stromal microenvironment through autocrine and paracrine stimulation, thereby significantly promoting oncogene transformation and tumor growth. Abnormal expression of FGFR1 in cells is considered to be the main cause of tumorigenesis and a potential target for the treatment of cancer. In this study, a combination of structure-based drug carriers and molecular docking-based virtual screening was used to screen new potential FGFR1 inhibitors. Twenty-one known inhibitors were collected as training sets to establish a 3D-QSAR pharmacophore model, and cost analysis, test set validation, and Fischer randomization test were used to validate the efficiency of the pharmacophore model. In Accelrys Discovery Studio 2016, the zinc database was filtered by Lipinski's Rule of Five and SMART's filtration. Then, Hypo01 was used for virtual screening of ZINC database. Compounds with predicted activity values less than 1 μM were molecularly docked with FGFR1 protein crystals, the docking results were observed, and the interaction between compounds and targets was studied. The absorption, distribution, metabolism and excretion (ADME) and toxicity of potential inhibitors were studied, and a compound with new structural scaffolds were obtained. It could be further studied to explore their better therapeutic effects.
Prevalence and Factors Associated With Anemia Among Pregnant Women Attending AMDA Hospital of Eastern Nepal
Authors: Acharya Gaurab , Sirichokchatchawan Wandee , Sanjel Keshab 
Published: September 2020

Abstract
BackgroundAnemia is a global public health problem, consisting 40% of pregnant women being anemic worldwide. Manifold factors directly or indirectly contribute to anemia during pregnancy and amplify the risk of maternal and fetal mortality and morbidity. However, factors associated with anemia among pregnant women are not broadly understood in sub-national level. Thus, this study has made an effort to ascertain the prevalence and associated factors of anemia among pregnant women in AMDA Hospital of Eastern Nepal. MethodsHealth-facility based cross-sectional study was conducted among pregnant women of age 18-49 years attending antenatal care (ANC) in AMDA Hospital. A total of 420 samples were recruited through systematic random sampling. Data was collected through a validated semi-structured questionnaire. Hemoglobin concentration was recorded from laboratory test report. Collected data were entered in EpiData and analyzed in SPSS Version 22 licensed by Chulalongkorn University. Chi-square test was used for bivariate analysis and later, significant variables at p-value<0.10 were processed on multivariate analysis. Finally, the adjusted odd ratio was reported considering significant at p-value <0.05 with 95% confidence interval. ResultsThe overall prevalence of anemia was 42.1% (37.4%–47.0%). Almost 46%, 41% and 14% of women were with mild, moderate and severe types respectively. Factors such as age less than 20 years (7.23, 2.50–20.87) and between 20- 24 years (2.80, 1.31–5.96), religious minorities (3.09, 1.35–7.06), vegetarian diet pattern (4.33, 1.49–12.59), inadequate frequency (DGLV: once a week, fruits: twice in a week) of eating DGLV (8.71, 2.26 – 33.63) and fruits (2.73, 1.41–2.29), inadequate dietary diversity (7.16, 3.15–16.27), as well as no intake of multivitamins during pregnancy (4.23, 1.49– 11.98) were statistically associated with anemia among pregnant women. ConclusionOverall, the prevalence of anemia was found to be high in the study area. The associated factors of anemia ranged from socio-economic, dietary and obstetric care, and included age, religion, diet pattern, and frequency of eating DGLV and fruits, dietary diversity, as well as intake of multivitamins during pregnancy. The study recommends enhancing community-based interventions considering the identified factors.
Seismic Vulnerability Assessment using Numerical Simulation for a Residential Buildings – A Case study
Authors: Mehjebin Jennifer , A.S Santhi , Ganapathy Ganapathy Pattukandan 
Published: September 2020

Abstract
Seismic vulnerability assessment of an existing building is of high importance for ensuring the safety of the structure and the occupants. An earthquake may not be predictable but seismic performance of a structure can be well- predicted in advance which aids in deciding the correct retrofit technique for a building ensuring the safety of the occupants. A RC building situated in the seismic zone III region of Vellore, Tamil Nadu has been taken into consideration for analysing its seismic vulnerability. The region is yet to catch engineering attention for evaluation of seismic performance of such buildings. With the help of the nearest fault line data, the PGA value was calculated and the value suggested moderate potential damage. The RVS score of the building was categorised in the high probability of Grade Damage 3 i.e. structural damage in moderate range and non-structural damage in heavy range. A detailed numerical analysis was carried out in ETABS using equivalent static force method to simulate the earthquake forces in the structure. Although a dynamic method of analysis considers higher magnitude of earthquake forces based on a more realistic earthquake excitation, equivalent static force analysis is sufficient for a preliminary analysis of the building. The building having a soft storey in the ground floor showed variations in its behaviour on application of earthquake forces in four different case scenarios of shear wall application. The maximum storey drifts were then compared for the building in cases of existing soft storey and with the application of shear wall in the ground floor, staircase walls and with a combination of shear wall in both the locations. The results showed that shear wall in the staircase proved to be the most economical retrofit solution for the building.
A Novel Four-MicroRNA Signature for Prognosis and Diagnosis in Colorectal Cancer
Authors: Chen Yan , Qin Ying , Zhou Yaoyao , Dai Mengmeng , Sun Qinsheng , Li Lulu , Qiu Cheng , Jiang Yuyang 
Published: September 2020

Abstract
Background and aims: Colorectal cancer (CRC) remains a global public health problem. We aimed to access prognostic microRNAs (miRNAs) associated with overall survival (OS) and evaluate their diagnostic value in CRC.Methods: Three serum miRNA expression profiles from Gene Expression Omnibus (GEO) database and tissue miRNA expression profile of CRC from The Cancer Genome Atlas (TCGA) database were studied to get common differentially expressed miRNA (DEmiRNAs) in serums and tissues. 569 CRC patients with survival information from TCGA database were randomly divided into the discovery and validation cohort. Based on the TCGA discovery cohort, the univariate cox analysis, least absolute shrinkage and selection operator (LASSO) regression analysis and multivariate cox proportional hazards regression analysis were performed and a prognostic signature was constructed. The prognostic capacity of the signature was verified in TCGA validation cohort and the prognostic signature expression in tumors and serums was validated in an independent microarray dataset and our clinical set. We also evaluated the diagnostic power of the model in serum by calculating the area under the receiver operating characteristic (ROC) curve in a clinical set. Functional enrichment analyses were applied to analyze the potential roles of the signature in CRC.Results: A total of 154 common DEmiRNAs were identified. Based on the TCGA discovery cohort, a four-miRNA (miR-10b, miR-130a, miR-561, miR-4684) prognostic signature was constructed and a predictive nomogram model including the expression of above four miRNAs showed good performance for predicting the 3- and 5-year overall survival. The findings were well verified in TCGA validation cohort. miR-10b, miR-130a, miR-561 and miR-4684 were significantly upregulated both in CRC tumors and serums. Circulating miR-10b, miR-130a, miR-561 and miR-4684 levels were significantly downregulated after surgical resection of tumor in CRC patients, suggesting these four circulating miRNAs in the serum were tumor derived. The four circulating miRNA combination might act as a novel diagnostic signature for CRC. Functional enrichment analyses suggested that above four miRNAs might be related to the progression of CRC. Conclusions: We developed a novel reliable prognostic and diagnostic signature, which should be beneficial for CRC screening and clinical therapeutic decision-making.
Development and Validation of A Seven-microRNA Signature as a Novel Prognostic Biomarker for Bladder Cancer
Authors: Lv Jin-Xing , Lin Fei , Ke Zhi-Bin , Lin Yun-Zhi , Zhuang Peng-Fei , Chen Ye-Hui , Chen Shao-Hao , Xue Xue-Yi , Zheng Qing-Shui , Wei Yong , Xu Ning 
Published: September 2020

Abstract
Background The differential expression of miRNAs has played a significant role in bladder tumors. The aim of our study was to screen new biomarkers . Methods Through differential analysis of bladder cancer mRNA and miRNA expression data in the TCGA, differential genes and miRNAs were screened. Furthermore, Cox univariate analysis and multifactor analysis were used to establish a prognostic prediction model . The predictive ability of the prognostic model was then verified on the patient. The action mechanism of these miRNAs was analyzed.Results By the differential analysis and standardization of miRNA expression profiles. Differentially expressed miRNAs were screened, then all the patients were then randomly divided into train group and the test group. 23 miRNAs were revealed , then a Seven-miRNA signature prognostic biomarkers was constituting.Univariate cox regression and multivariate cox regression considering other clinical factors displayed that the seven-miRNA signature could serve as an independent prognostic factor.Target genes of these seven miRNAs were analyzed by KEGG signaling pathway and GO enrichment analysis. . Conclusion The prognostic model constructed by seven miRNAs has possessed certain degree of sensitivity and specificity for the prediction of the survival of bladder cancer patients, which can be used as a potential new clinical marker for bladder cancer patients.
A pedagogia como alicerce da teoria política em Rousseau
Authors: Calil Breymaier Sophia , Boto Carlota 
Published: September 2020

O presente artigo procura - através de uma análise crítica e explicativa, baseada em estudos de bibliografia das obras de Rousseau, centrando-se principalmente nos Discursos e em Emílio - evidenciar de que maneira o conceito de natureza, na perspectiva da teoria política e social desenvolvida por Rousseau, se coaduna com aquele expresso em sua obra pedagógica Propõe-se a investigar as bases filosóficas do pensamento rousseauniano para analisar o conceito de natureza e o homem, articulando-o com o modo pelo qual outros autores contratualistas pensaram o mesmo problema. Busca por fim expor uma possível unidade no pensamento político e pedagógico de Rousseau, para desenvolver, à luz de suas ideias, a construção de uma teoria acerca dos fundamentos da sociedade e do direito natural, bem como de um projeto de pedagogia natural e moral para que fosse possível estabelecer a vontade geral.
Pornodyssey
Authors: Cooper Jennifer Sarah 
Published: September 2020

The celebrated novel Pornopopéia, by Reinaldo Moraes, represents a type of joycean Ulysses of the city of São Paulo’s underground in the excesses of the 1980s extended to the beginning of the 21st century. Despite its importance in contemporary Brazilian literature and perhaps because of its literary and linguistic complexity in producing its distinct humor, it has never before been translated into English. This article reports some results of a post-doctoral research in which we carried out a literary, commented translation of this epic novel. The theoretical framework of the research was based in general on a model of language from the perspective of the Theory of Genre and Register (TGR) (MARTIN; ROSE, 2008) and on Berman’s concept of ‘tradutology’ (2012), while the translation practice was informed by adaptations of Rothenberg’s concept of ‘total translation’ (2010), Frota’s Jazz Theory (1989), Toury’s ‘norms’ (1995), Milton’s (1998) discussion of metaphors for the practice of translation. Some results point to the following features as contributing to humor and presenting distinct challenges in the process of translating them: code-mixing and switching, punning haiku, rapid changes in registers from erudite to street, sonority (hard rhymes), neologisms, blends, and other linguistic, semantic and generic transgressions, along with those of a social nature. Ultimately, with this research we hope to offer the anglophone reader the pleasure of this text by Reinaldo Moraes, simultaneously disseminating Brazilian literature and culture to a broad anglophone speech community through the translation, and ultimately contributing to reflections on the practice of translation in translation studies.
Xigua Video as a Source of Information on Breast Cancer: Content Analysis
Authors: Pan Peng , Yu Changhua , Li Tao , Zhou Xilei , Dai Tingting , Tian Hanhan , Xiong Yaozu 
Published: September 2020

Background
Seeking health information on the internet is a popular trend. Xigua Video, a short video platform in China, ranks among the most accessed websites in the country and hosts an increasing number of videos with medical information. However, the nature of these videos is frequently unscientific, misleading, or even harmful.

Objective
Little is known about Xigua Video as a source of information on breast cancer. Thus, the study aimed to investigate the contents, quality, and reliability of breast cancer–related content on Xigua Video.

Methods
On February 4, 2020, a Xigua Video search was performed using the keyword “breast cancer.” Videos were categorized by 2 doctors based on whether the video content provided useful or misleading information. Furthermore, the reliability and quality of the videos were assessed using the 5-point DISCERN tool and 5-point global quality score criteria.

Results
Out of the 170 videos selected for the study, 64 (37.6%) were classified as useful, whereas 106 (62.4%) provided misleading information. A total of 41.8% videos (71/170) were generated by individuals compared to 19.4% videos (33/170) contributed by health care professionals. The topics mainly covered etiology, anatomy, symptoms, preventions, treatments, and prognosis. The top topic was “treatments” (119/170, 70%). The reliability scores and global quality scores of the videos in the useful information group were high (P<.001). No differences were observed between the 2 groups in terms of video length, duration in months, and comments. The number of total views was higher for the misleading information group (819,478.5 vs 647,940) but did not reach a level of statistical significance (P=.112). The uploading sources of the videos were mainly health care professionals, health information websites, medical advertisements, and individuals. Statistical differences were found between the uploading source groups in terms of reliability scores and global quality scores (P<.001). In terms of total views, video length, duration, and comments, no statistical differences were indicated among the said groups. However, a statistical difference was noted between the useful and misleading information video groups with respect to the uploading sources (P<.001).

Conclusions
A large number of Xigua videos pertaining to breast cancer contain misleading information. There is a need for accurate health information to be provided on Xigua Video and other social media; health care professionals should address this challenge.
Functional changes in the temporomandibular joint mechanoreceptors associated with experimentally induced condylar resorption in rats
Authors: Naito Satomi , Kato Chiho , Yabushita Tadachika , Ono Takashi 
Published: September 2020

ABSTRACT

Objectives
To evaluate the influence of experimentally induced progressive condylar resorption (PCR) on temporomandibular joint (TMJ) mechanoreception.

Materials and Methods
Twenty 13-week-old male albino Wistar rats were divided equally into control and PCR groups. A compressive force was loaded on the left TMJ of PCR group rats to induce condylar resorption. Single-unit activities of TMJ mechanoreceptors were also induced through passive jaw movement. Recording was performed for the left Gasserian ganglion at 3 days and 1 week after the establishment of PCR group. The effects of PCR on TMJ units were assessed by measuring the firing threshold, maximum instantaneous firing frequency, and average firing frequency.

Results
Compared with the control group, there were no significant differences in the firing threshold of the PCR group after 3 days. The thresholds were significantly higher 1 week after compressive force loading on the condyle. The maximum instantaneous firing frequencies and the average firing frequencies showed no significant differences after 3 days. However, these were significantly lower 1 week after compressive force loading.

Conclusions
The findings suggest that compressive force loading on the condyle may influence the function of TMJ mechanoreceptors.
SISTEM PELAYANAN BANTUAN MENTOR BIMBINGAN BELAJAR (BAMBIMBEL) BERBASIS WEB
Authors: Ranuharja Fadhli , Fajri Bayu Ramadhani , Samala Agariadne Dwinggo 
Published: September 2020

Adanya tuntutan penerimaan mahasiswa baru dengan menggunakan ujian Seleksi Nasional Perguruan Tinggi Negeri (SNMPTN) di Indonesia, siswa lulusan SMA/SMK diharapkan menguasai beberapa mata pelajaran dasar. Berdasarkan data primer wawancara penjurusan siswa yang dilakukan SMA/SMK di Indonesia belum cukup untuk membekali siswa dalam persiapan mengikuti ujian seleksi nasional, layanan bimbingan belajar didominasi jumlah terbanyak di kota besar, kemudian mahalnya biaya bimbingan belajar membuat siswa sulit punya kesempatan untuk mengikuti bimbingan belajar sehingga perlu dirancang sistem pelayanan bimbingan belajar yang dapat diikuti oleh siswa tanpa dibatasi ruang dan waktu. Salah satunya adalah sistem bimbingan belajar berbasis web. Bimbingan belajar termasuk salah satu Pendidikan non-formal. Pasal 1 angka 12 Undang-Undang Nomor 20 Tahun 2003 tentang Sistem Pendidikan Nasional menyatakan pendidikan non-formal adalah jalur pendidikan di luar pendidikan formal yang dapat dilaksanakan secara terstruktur dan berjenjang. Tujuan dari penelitian ini adalah merancang dan menghasilkan sebuah sistem pelayanan bantuan mentor bimbingan belajar (BAMBIMBEL). BAMBIMBEL juga memfasilitasi siswa yang ingin belajar untuk persiapan seleksi perguruan tinggi negeri. Metode yang digunakan adalah metode perancangan sistem berbasis web dengan pemodelan Unified Modeling Language (UML), pengujian sistem menggunakan metode Black Box, berdasarkan pengujian yang diamati dapat disimpulkan hasil eksekusi melalui data uji dan fungsionalitas dari sistem BAMBIMBEL berjalan dengan baik dan sesuai dengan yang diharapkan