bluuebunny/crossref_metadata_2025_split huggingface dataset:
A tumor-specific modulation of heterogeneous ribonucleoprotein A0 promotes excessive mitosis and growth in colorectal cancer cells
Authors: Konishi Hiroaki , Fujiya Mikihiro , Kashima Shin , Sakatani Aki , Dokoshi Tatsuya , Ando Katsuyoshi , Ueno Nobuhiro , Iwama Takuya , Moriichi Kentaro , Tanaka Hiroki , Okumura Toshikatsu 
Published: April 2020

AbstractRNA regulation mediating RNA-binding proteins (RBPs) have been shown to be related to the maintenance of homeostasis as well as cancer progression. However, the tumor-associated functions as well as the detailed mechanisms underlying the anti-tumor effects of most RBPs have yet to be explored. We herein report that the phosphorylated heterogeneous ribonucleoprotein (hnRNP) A0 promotes mitosis through the RAS-associated protein 3 GTPase-activating protein catalytic subunit 1 (RAB3GAP1)-Zeste white 10 interactor (ZWINT1) cascade. The downregulation assay of 20 representative hnRNPs, a major family of RNA-binding proteins, in colorectal cancer cells revealed that hnRNPA0 is a strong regulator of cancer cell growth. The tumor promotive function of hnRNPA0 was confirmed in gastrointestinal cancer cells, including pancreatic, esophageal, and gastric cancer cells, but not in non-cancerous cells. Flow cytometry and Western blotting analyses revealed that hnRNPA0 inhibited the apoptosis through the maintenance of G2/M phase promotion in colorectal cancer cells. A comprehensive analysis of mRNAs regulated by hnRNP A0 and immunostaining revealed that mitotic events were regulated by the hnRNPA0-RAB3GAP1 mRNA-mediated ZWINT-1 stabilization in colorectal cancer cells, but not in non-tumorous cells. The interaction of hnRNP A0 with mRNAs was dramatically changed by the deactivation of its phosphorylation site in cancer cells, but not in non-tumorous cells. Therefore, the tumor-specific biological functions characterized by the abnormal phosphorylation of RBPs are considered to be an attractive target for tumor treatment.
Accuracy of the Language Environment Analysis System Segmentation and Metrics: A Systematic Review
Authors: Cristia Alejandrina , Bulgarelli Federica , Bergelson Elika 
Published: April 2020

PurposeThe Language Environment Analysis (LENA) system provides automated measures facilitating clinical and nonclinical research and interventions on language development, but there are only a few, scattered independent reports of these measures' validity. The objectives of the current systematic review were to (a) discover studies comparing LENA output with manual annotation, namely, accuracy of talker labels, as well as involving adult word counts (AWCs), conversational turn counts (CTCs), and child vocalization counts (CVCs); (b) describe them qualitatively; (c) quantitatively integrate them to assess central tendencies; and (d) quantitatively integrate them to assess potential moderators.MethodSearches on Google Scholar, PubMed, Scopus, and PsycInfo were combined with expert knowledge, and interarticle citations resulting in 238 records screened and 73 records whose full text was inspected. To be included, studies must target children under the age of 18 years and report on accuracy of LENA labels (e.g., precision and/or recall) and/or AWC, CTC, or CVC (correlations and/or error metrics).ResultsA total of 33 studies, in 28 articles, were discovered. A qualitative review revealed most validation studies had not been peer reviewed as such and failed to report key methodology and results. Quantitative integration of the results was possible for a broad definition of recall and precision (M= 59% and 68%, respectively;N= 12–13), for AWC (meanr= .79,N= 13), CVC (meanr= .77,N= 5), and CTC (meanr= .36,N= 6). Publication bias and moderators could not be assessed meta-analytically.ConclusionFurther research and improved reporting are needed in studies evaluating LENA segmentation and quantification accuracy, with work investigating CTC being particularly urgent.Supplemental Materialhttps://osf.io/4nhms/
The SOPHIE search for northern extrasolar planets
Authors: Hara N. C. , Bouchy F. , Stalport M. , Boisse I. , Rodrigues J. , Delisle J.-B. , Santerne A. , Henry G. W. , Arnold L. , Astudillo-Defru N. , Borgniet S. , Bonfils X. , Bourrier V. , Brugger B. , Courcol B. , Dalal S. , Deleuil M. , Delfosse X. , Demangeon O. , Díaz R. F. , Dumusque X. , Forveille T. , Hébrard G. , Hobson M. J. , Kiefer F. , Lopez T. , Mignon L. , Mousis O. , Moutou C. , Pepe F. , Rey J. , Santos N. C. , Ségransan D. , Udry S. , Wilson P. A. 
Published: April 2020

Aims.Since 2011, the SOPHIE spectrograph has been used to search for Neptunes and super-Earths in the northern hemisphere. As part of this observational program, 290 radial velocity measurements of the 6.4Vmagnitude star HD 158259 were obtained. Additionally, TESS photometric measurements of this target are available. We present an analysis of the SOPHIE data and compare our results with the output of the TESS pipeline.Methods.The radial velocity data, ancillary spectroscopic indices, and ground-based photometric measurements were analyzed with classical and ℓ1periodograms. The stellar activity was modeled as a correlated Gaussian noise and its impact on the planet detection was measured with a new technique.Results.The SOPHIE data support the detection of five planets, each withmsini ≈ 6 M⊕, orbiting HD 158259 in 3.4, 5.2, 7.9, 12, and 17.4 days. Though a planetary origin is strongly favored, the 17.4 d signal is classified as a planet candidate due to a slightly lower statistical significance and to its proximity to the expected stellar rotation period. The data also present low frequency variations, most likely originating from a magnetic cycle and instrument systematics. Furthermore, the TESS pipeline reports a significant signal at 2.17 days corresponding to a planet of radius ≈1.2 R⊕. A compatible signal is seen in the radial velocities, which confirms the detection of an additional planet and yields a ≈2 M⊕mass estimate.Conclusions.We find a system of five planets and a strong candidate near a 3:2 mean motion resonance chain orbiting HD 158259. The planets are found to be outside of the two and three body resonances.
Paraspinale Tumore: Epidemiologie, Diagnostik und Therapie
Authors: Rüter Andreas , Ebner Florian H. 
Published: April 2020

ZusammenfassungParaspinale Tumore breiten sich entlang der Wirbelsäule in den umgebenden Geweben wie Knochen, Muskulatur, Bindegewebe und Bandscheiben aus. Sie betreffen dadurch mitunter die Halsweichteile, den intrathorakalen sowie retroperitonealen Raum. Eine Unterscheidung erfolgt anatomisch, nach Ursprung oder nach Dignität. Grundlage der Diagnostik stellt die Schnittbildgebung in Form von MRT und CT dar. Bei der Planung des operativen Vorgehens muss insbesondere das Vorliegen einer Instabilität oder die Kompression neuraler Strukturen berücksichtigt werden. Therapeutische Optionen werden interdisziplinär erörtert. Ergänzend zur Operation stellen die Radio- und Chemotherapie alternative oder zusätzliche Therapieoptionen dar.
Vegetative Versorgung des kleinen Beckens
Authors: Corts Magga 
Published: April 2020

SummaryIm kleinen Becken liegen die Organe Harnblase und Rektum. Bei der Frau befinden sich zusätzlich noch die Organe Vagina, Uterus und Ovarien im kleinen Becken. Beim Mann liegt unterhalb der Harnblase die Prostata. Eine reibungslose vegetative Versorgung des kleinen Beckens ist für die Funktion der Sexualorgane unerlässlich. Vegetativ zuständig sind der Plexus hypogastricus superior und inferior.
Anamnese mit Tabus?
Authors: Lummer Birgit 
Published: April 2020

SummaryDie meisten Paare leiden zumindest phasenweise unter verminderter Sexualität und Nähe bis hin zu Sprachlosigkeit, Einsamkeit und Entfremdung. Während Urologen und Gynäkologen vorwiegend die organischen Aspekte abklären, sprechen andere Therapeuten die Sexualität meist gar nicht erst an, obwohl die Patienten sich dies überwiegend wünschen. Einfühlsame Fragen nach der sexuellen Zufriedenheit können wichtige Türen zu mehr seelischer und körperlicher Gesundheit sowie erfüllter Partnerschaft öffnen, so auch im vorgestellten Fall.
(TCM-)Wege aus der Fertilitätskrise
Authors: Bögel-Witt Martina 
Published: April 2020

SummaryTrotz Kinderwunsch kommt es bei jedem fünften Paar auf natürlichem Weg nicht zu einer Schwangerschaft, unter anderem bedingt durch langjährige Pilleneinnahme und ein steigendes Alter der Erstgebärenden und ihrer Partner. Durch eine Kombination moderner Verfahren wie der In-vitro- Fertilisation mit Methoden der TCM lassen sich die Chancen für eine erfolgreiche Schwangerschaft erhöhen. Die chinesische Medizin legt den Fokus insbesondere auf Zang-Organe, charakteristische Zyklusphasen sowie TCM-Syndrome und unterstützt die Fertilisation mit spezifischen Kräuterrezepturen und Akupunkturverfahren.
Pertussis – die unendliche Geschichte?
Authors: Liese Johannes G. 
Published: April 2020

ZUSAMMENFASSUNGPertussis, die häufigste Form des Keuchhustens, ist eine meldepflichtige Infektionskrankheit des Respirationstraktes, die durch Bordetella pertussis verursacht wird. In ungeimpften Populationen tritt Pertussis überwiegend im Alter zwischen 2 und 6 Jahren auf. Trotz hoher Pertussis-Durchimpfungsraten im Säuglings- und Kleinkindesalter werden in den letzten 20 Jahren eine Zunahme der Inzidenz und eine Verschiebung von Pertussiserkrankungen in das Adoleszenten- und Erwachsenenalter beobachtet. Dies liegt an 3 Ursachen: erstens an der erhöhten Aufmerksamkeit bei Patienten und Ärzten gegenüber Pertussis, zweitens der einfacheren Diagnosestellung durch sensitive Methoden wie der PCR oder Serologie und drittens an der zeitlich begrenzten Wirksamkeit von Pertussisimpfstoffen. Regelmäßige Auffrischimpfungen auch über das Kindesalter hinaus sind von hoher Bedeutung, um Ausbreitung, Ausbrüche und Komplikationen der Pertussis zu begrenzen. Die bestehenden Empfehlungen zur Pertussisimpfung im Erwachsenenalter werden jedoch nur unzureichend umgesetzt. Die fehlende Empfehlung der STIKO analog zu Diphtherie und Tetanus gegen Pertussis alle 10 Jahre zu impfen, trägt ebenfalls dazu bei, dass die Impfung bei Erwachsenen kaum durchgeführt wird. Dadurch entstehen Übertragungswege auf ungeimpfte Neugeborene und Säuglinge, die das höchste Komplikations- und Mortalitätsrisiko tragen. Hohe Durchimpfungsraten und regelmäßige mindestens 10-jährige Auffrischimpfungen auch im Erwachsenenalter sind die beste Präventionsstrategie und dringend erforderlich, um die weitere Ausbreitung von Pertussis zu begrenzen. Eine maternale (Auffrisch-) Impfung im letzten Trimenon der Schwangerschaft kann zusätzlich Pertussis bei Neugeborenen wirksam verhindern. Die Entwicklung neuer wirksamerer Pertussisimpfstoffe ist notwendig, um den Keuchhusten in seinen unterschiedlichen klinischen Ausprägungen zu kontrollieren.
Endoscopic closure of refractory esophageal fistula after esophagectomy using polyglycolic acid sheets: a pilot study
Authors: Nagami Yasuaki , Ominami Masaki , Sakai Taishi , Fukunaga Shusei , Tanaka Fumio , Taira Koichi , Tanigawa Tetsuya , Lee Shigeru , Watanabe Toshio , Fujiwara Yasuhiro 
Published: April 2020

Abstract
Background and study aims Esophageal fistulas after esophagectomy are associated with high mortality and poor quality of life. They are sometimes intractable to conservative management and surgery that increases mortality. Few studies have assessed use of polyglycolic acid (PGA) sheets with fibrin glue for esophageal fistulas. We investigated the safety of using PGA sheets with fibrin glue for esophageal fistulas after esophagectomy.
Patients and methods This was a single-center prospective pilot study. Patients who had refractory esophageal fistulas after esophagectomy were included. PGA sheets were filled in the fistula using biopsy forceps. Fibrin glue was applied to the PGA sheets. We repeated the procedure 1 week later. The outcome measures were the incidence of adverse events (AEs) and closure of the fistula.
Results Five patients were assessed. No adverse events were observed. The esophageal fistula was closed with the application of PGA sheets four times in 40 % (2/5) of the cases.
Conclusions PGA sheets with fibrin glue were safe for esophageal fistula closure after esophagectomy and do not involve the risk of AEs.
Modellprojekt: Waldmedizin zur Prävention und Therapie bei Burn-out
Authors: Ihlow Christiane , Lamminger Simone 
Published: April 2020

SummaryDas Waldbaden bietet durch das bewussteErleben der Natur heilsame Wirkungen aufdas vegetative Nervensystem. Im Rahmeneiner Kooperation zwischen der Klinik und dem Forstamtsverbund Wald und Holz NRWwurden die positiven Effekte dieser Methode zur Therapie und Prävention von Burnouterforscht. Daraus entstand ein Modellprojekt der Primärprävention. Trotz der positivenErgebnisse konnte das Projekt jedoch keine Zulassung als Präventionsangebotnach § 20 SGB V erreichen.
Digitales Gift
Authors: Otto Daniela 
Published: April 2020

SummaryMailen, posten, twittern, googeln: Immer mehr Menschenfühlen sich von digitalen Medien gestresst, vielesind sogar süchtig danach. Das ist gefährlich – vor allem, da das Krankheitsbild „Smartphonesucht“ immer nochunterschätzt wird. Digital Detox hilft gegen Stress undkann als beste Prävention gegen Abhängigkeit angesehenwerden. Dieser Beitrag zeigt, wie die digitale EntgiftungSchritt für Schritt gelingt.
Natur als Therapie und Prävention
Authors: Michalsen Andreas 
Published: April 2020

SummaryDem Aufenthalt in der Natur werden bereitsin der griechischen „diaita“ Heil- und Gesundheitswirkungenzugesprochen. Auch inder Praxis und den Lehren naturheilkundlicherPioniere wie Kneipp, Prießnitz oderBircher-Benner ist dies fester Bestandteil.Die Anzahl an Studien, welchen Einfluss dieNatur z. B. in Form von Waldbaden oder einerurbanen grünen Umgebung auf die Gesundheithat, nimmt stetig zu. Auf dieser Basis kann konstatiert werden, dass wohnortnaheurbane Grünflächen insbesondere zur Prävention psychischer sowie pulmonalerund kardiovaskulärer Erkrankungen sehr wichtig sind. Es finden sich besonders Hinweisefür Vorteile von Wildwiesen, biodiversem Urban Gardening sowie die Bedeutungvon Bäumen und natürlich durchmischten Wäldern.Für die individuelle Therapie kann der gezielteAufenthalt in der Natur, am besten imWald oder auf biodiversen Grünflächen mitWassernähe als besonders effektiv bewertet werden.
Bluthochdrucksenkung durch hämatogene Ausleitung
Authors: Görgner Anke 
Published: April 2020

SummaryIn der Literatur sind ausleitende Methodenwie das blutige Schröpfen zur Blutdrucksenkungmehrfach als erfolgreich beschriebenworden. Beobachtungen aus der Praxis derAutorin zeigten beim blutigen Schröpfen mitdem Ziel der Schmerztherapie relevanteBlutdrucksenkungen. In einer kleinen Fallseriemit 8 Patienten konnten systolische Blutdrucksenkungenvon im Mittel 43 mmHgbeobachtet werden.Aufgrund der Beobachtungen plant die Autorineine Interventionsstudie, um möglicheblutdrucksenkende Wirkungen des blutigenSchröpfens zu eruieren und zu weiterer Forschunganzuregen.
ESGE and ESGENA Position Statement on gastrointestinal endoscopy and the COVID-19 pandemic
Authors: Gralnek Ian M. , Hassan Cesare , Beilenhoff Ulrike , Antonelli Giulio , Ebigbo Alanna , Pellisè Maria , Arvanitakis Marianna , Bhandari Pradeep , Bisschops Raf , Van Hooft Jeanin E. , Kaminski Michal F. , Triantafyllou Konstantinos , Webster George , Pohl Heiko , Dunkley Irene , Fehrke Björn , Gazic Mario , Gjergek Tatjana , Maasen Siiri , Waagenes Wendy , de Pater Marjon , Ponchon Thierry , Siersema Peter D. , Messmann Helmut , Dinis-Ribeiro Mario 
Published: April 2020

AbstractWe are currently living in the throes of the COVID-19 pandemic that imposes a significant stress on health care providers and facilities. Europe is severely affected with an exponential increase in incident infections and deaths. The clinical manifestations of COVID-19 can be subtle, encompassing a broad spectrum from asymptomatic mild disease to severe respiratory illness. Health care professionals in endoscopy units are at increased risk of infection from COVID-19. Infection prevention and control has been shown to be dramatically effective in assuring the safety of both health care professionals and patients. The European Society of Gastrointestinal Endoscopy (www.esge.com) and the European Society of Gastroenterology and Endoscopy Nurses and Associates (www.esgena.org) are joining forces to provide guidance during this pandemic to help assure the highest level of endoscopy care and protection against COVID-19 for both patients and endoscopy unit personnel. This guidance is based upon the best available evidence regarding assessment of risk during the current status of the pandemic and a consensus on which procedures to perform and the priorities on resumption. We appreciate the gaps in knowledge and evidence, especially on the proper strategy(ies) for the resumption of normal endoscopy practice during the upcoming phases and end of the pandemic and therefore a list of potential research questions is presented. New evidence may result in an updated statement.
Donald A. B. Lindberg: Inspiring Leader and Visionary in Biomedicine, Healthcare, and Informatics
Authors: Kulikowski Casimir A. 
Published: April 2020

Summary
Background: As Director of the US National Library of Medicine (NLM) for 30 years, Dr. Donald A. B. Lindberg was instrumental in bringing biomedical research and healthcare worldwide into the age of genomic and translational medicine through the informatics systems developed by the NLM. Lindberg opened free access and worldwide public dissemination of all the NLM's biomedical literature and databases, thus helping transform not only biomedical research like the Human Genome Project and its successors, but also the practices of medicine and healthcare internationally. Guiding, leading, and teaching-by-example at national, regional, and global levels of biomedical and healthcare informatics, Lindberg helped coalesce a dynamic discipline that provides a foundation for the human understanding which promotes the future health of our world.
Objectives: To provide historical insight into the scientific, technological, and practical clinical accomplishments of Donald Lindberg, and to describe how this led to contributions in the worldwide interdisciplinary evolution of informatics, and its impact on the biosciences and practices of medicine, nursing, and other healthcare-related disciplines.
Methods: Review and comment on the publications, scientific contributions, and leadership of Donald Lindberg in the evolution of biomedical and health informatics which anticipate the vision, scholarship, research in the field, and represent the deeply ethical humanism he exhibited throughout his life. These were essential in producing the informatics systems, such as the Unified Medical Language System (UMLS), MEDLINE, PubMed, PubMed Central, and ClinicalTrials.gov, which, together with NLM training programs and conferences, made possible the interactions among researchers and practitioners leading to the past quarter-century of rapid and dramatic advances in biomedical scientific inquiry and clinical discoveries, openly shared across the globe.
Conclusion: Dr. Lindberg was a uniquely talented physician and pioneering researcher in biomedical and health informatics. As the main leader in developing and funding innovative informatics research for more than 30 years as Director of the National Library of Medicine, he helped bring together the most creative interdisciplinary researchers to bridge the worlds of biomedical research, education, and clinical practice. Lindberg's emphasis on open-access to the biomedical literature through publicly shared computer-mediated methods of search and inquiry are seen as an example of ethical scientific openness.
Progress in Characterizing the Human Exposome: a Key Step for Precision Medicine
Authors: Martin-Sanchez Fernando , Bellazzi Riccardo , Casella Vittorio , Dixon William , Lopez-Campos Guillermo , Peek Niels 
Published: April 2020

Summary
Objective: Most diseases result from the complex interplay between genetic and environmental factors. The exposome can be defined as a systematic approach to acquire large data sets corresponding to environmental exposures of an individual along her/ his life. The objective of this contribution is to raise awareness within the health informatics community about the importance of dealing with data related to the contribution of environmental factors to individual health, particularly in the context of precision medicine informatics.
Methods: This article summarizes the main findings after a panel organized by the International Medical Informatics Association - Exposome Informatics Working Group held during the last MEDINFO, in Lyon (France) in August 2019.
Results: The members of our community presented four initiatives (PULSE, Digital exposome, Cloudy with a chance of pain, Wearable clinics), providing a detailed view of current challenges and accomplishments in processing environmental and social data from a health research perspective. Projects illustrate a wide range of research methods, digital data collection technologies, and analytics and visualization tools. This reinforces the idea that this area is now ready for health informaticians to step in and contribute their expertise, leading the application of informatics strategies to understand environmental health problems.
Conclusions: The featured projects illustrate applications that use exposome data for the investigation of the causes of diseases, health care, patient empowerment, and public health. They offer a rich overview of the expanding range of applications that informatics is finding in the field of environmental health, with potential impact in precision medicine.
Ethics in Telehealth: Comparison between Guidelines and Practice-based Experience -the Case for Learning Health Systems
Authors: Kuziemsky Craig E. , Hunter Inga , Gogia Shashi B. , lyenger Sriram , Kulatunga Gumindu , Rajput Vije , Subbian Vignesh , John Oommen , Kleber Araujo , Mandirola Humberto F. , Florez-Arango Jose , Al-Shorbaji Najeeb , Meher Sushil , Udayasankaran Jai Ganesh , Basu Arindam 
Published: April 2020

Summary
Objectives: To understand ethical issues within the tele-health domain, specifically how well established macro level telehealth guidelines map with micro level practitioner perspectives.
Methods: We developed four overarching issues to use as a starting point for developing an ethical framework for telehealth. We then reviewed telemedicine ethics guidelines elaborated by the American Medical Association (AMA), the World Medical Association (WMA), and the telehealth component of the Health Professions council of South Africa (HPCSA). We then compared these guidelines with practitioner perspectives to identify the similarities and differences between them. Finally, we generated suggestions to bridge the gap between ethics guidelines and the micro level use of telehealth.
Results: Clear differences emerged between the ethics guidelines and the practitioner perspectives. The main reason for the differences were the different contexts where telehealth was used, for example, variability in international practice and variations in the complexity of patient-provider interactions. Overall, published guidelines largely focus on macro level issues related to technology and maintaining data security in patient-provider interactions while practitioner concern is focused on applying the guidelines to specific micro level contexts.
Conclusions: Ethics guidelines on telehealth have a macro level focus in contrast to the micro level needs of practitioners. Work is needed to close this gap. We recommend that both telehealth practitioners and ethics guideline developers better understand healthcare systems and adopt a learning health system approach that draws upon different contexts of clinical practice, innovative models of care delivery, emergent data and evidence-based outcomes. This would help develop a clearer set of priorities and guidelines for the ethical conduct of telehealth.