bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on the Effects of Cone Height on the Turbulent Nonpremixed Flames Downstream of a Conical Bluff Body
Authors: Ata Alper , Bedii Ozdemir I. 
Published: October 2020

Abstract
Flow, thermal, and emission characteristics of turbulent nonpremixed CH4 flames were investigated for three burner heads of different cone heights. The fuel velocity was kept constant at 15 m/s, while the coflow air speed was varied between 0 and 7.4 m/s. Detailed radial profiles of the velocity and temperature were obtained in the bluff body wake at three vertical locations of 0.5D, 1D, and 1.5D. Emissions of CO2, CO, NOx, and O2 were also measured at the tail end of every flame. Flames were digitally photographed to support the point measurements with the visual observations. Fifteen different stability points were examined, which were the results of three bluff body variants and five coflow velocities. The results show that a blue-colored ring flame is formed, especially at high coflow velocities. The results also illustrate that depending on the mixing at the bluff-body wake, the flames exhibit two modes of combustion regimes, namely fuel jet- and coflow-dominated flames. In the jet-dominated regime, the flames become longer when compared with the flames of the coflow-dominated regime. In the latter regime, emissions were largely reduced due to the dilution by the excess air, which also surpasses their production.
Review of Computational Fluid Dynamics Studies on Chemical Looping Combustion
Authors: Shao Yali , Agarwal Ramesh K. , Wang Xudong , Jin Baosheng 
Published: October 2020

Abstract
Chemical looping combustion (CLC) is an attractive technology to achieve inherent CO2 separation with low energy penalty. In CLC, the conventional one-step combustion process is replaced by two successive reactions in two reactors, a fuel reactor (FR) and an air reactor (AR). In addition to experimental techniques, computational fluid dynamics (CFD) is a powerful tool to simulate the flow and reaction characteristics in a CLC system. This review attempts to analyze and summarize the CFD simulations of CLC process. Various numerical approaches for prediction of CLC flow process are first introduced and compared. The simulations of CLC are presented for different types of reactors and fuels, and some key characteristics including flow regimes, combustion process, and gas-solid distributions are described in detail. The full-loop CLC simulations are then presented to reveal the coupling mechanisms of reactors in the whole system such as the gas leakage, solid circulation, redox reactions of the oxygen carrier, fuel conversion, etc. Examples of partial-loop CLC simulation are finally introduced to give a summary of different ways to simplify a CLC system by using appropriate boundary conditions.
Effects of Time of Day on Pacing in a 4-km Time Trial in Trained Cyclists
Authors: Zadow Emma K. , Fell James W. , Kitic Cecilia M. , Han Jia , Wu Sam S. X. 
Published: October 2020

Context:Time of day has been shown to impact athletic performance, with improved performance observed in the late afternoon–early evening. Diurnal variations in physiological factors may contribute to variations in pacing selection; however, research investigating time-of-day influence on pacing is limited.Purpose:To investigate the influence of time-of-day on pacing selection in a 4-km cycling time trial (TT).Methods:Nineteen trained male cyclists (mean [SD] age 39.0 [10.7] y, height 1.8 [0.1] m, body mass 78.0 [9.4] kg, VO2max 62.1 [8.7] mL·kg−1·min−1) completed a 4-km TT on 5 separate occasions at 08:30, 11:30, 14:30, 17:30, and 20:30. All TTs were completed in a randomized order, separated by a minimum of 2 d and maximum of 7 d.Results:No time-of-day effects were observed in pacing as demonstrated by similar power outputs over 0.5-km intervals (P = .78) or overall mean power output (333.0 [38.9], 339.8 [37.2], 335.5 [31.2], 336.7 [35.2], and 334.9 [35.7] W;P = .45) when TTs were performed at 08:30, 11:30, 14:30, 17:30, and 20:30. Preexercise tympanic temperature demonstrated a time-of-day effect (P < .001), with tympanic temperature higher at 14:30 and 17:30 than at 08:30 and 11:30.Conclusion:While a biological rhythm was present in tympanic temperature, pacing selection and performance when completing a 4-km cycling TT were not influenced by time of day. The findings suggest that well-trained cyclists can maintain a robust pacing strategy for a 4-km TT regardless of time of the day.
Azole and Amphotericin B MIC Values against
Aspergillus fumigatus
: High Agreement between Spectrophotometric and Visual Readings Using the EUCAST EDef 9.3.2 Procedure
Authors: Serrano-Lobo Julia , Gómez Ana , Sánchez-Yebra Waldo , Fajardo Miguel , Lorenzo Belén , Sánchez-Reus Ferrán , Vidal Inmaculada , Fernández-Torres Marina , Sánchez-Romero Isabel , Ruiz de Alegría-Puig Carlos , del Pozo José Luis , Muñoz Patricia , Escribano Pilar , Guinea Jesús 
Published: October 2020

The EUCAST EDef 9.3.2 procedure recommends visual readings of azole and amphotericin B MICs against
Aspergillus
spp. Visual determination of MICs may be challenging. In this work, we aim to obtain and compare visual and spectrophotometric MIC readings of azoles and amphotericin B against
Aspergillus fumigatus
sensu lato
isolates. A total of 847
A. fumigatus
sensu lato
isolates (
A. fumigatus sensu stricto
[
n
= 828] and cryptic species [
n
= 19]) were tested against amphotericin B, itraconazole, voriconazole, posaconazole, and isavuconazole using the EUCAST EDef 9.
Sex differences in cardiometabolic risk factors, pharmacological treatment and risk factor control in type 2 diabetes: findings from the Dutch Diabetes Pearl cohort
Authors: de Jong Marit , Oskam Marieke J , Sep Simone J S , Ozcan Behiye , Rutters Femke , Sijbrands Eric J G , Elders Petra J M , Siegelaar Sarah E , DeVries J Hans , Tack Cees J , Schroijen Marielle , de Valk Harold W , Abbink Evertine J , Stehouwer Coen D A , Jazet Ingrid , Wolffenbuttel Bruce H R , Peters Sanne A E , Schram Miranda T 
Published: October 2020

IntroductionSex differences in cardiometabolic risk factors and their management in type 2 diabetes (T2D) have not been fully identified. Therefore, we aimed to examine differences in cardiometabolic risk factor levels, pharmacological treatment and achievement of risk factor control between women and men with T2D.Research design and methodsCross-sectional data from the Dutch Diabetes Pearl cohort were used (n=6637, 40% women). Linear and Poisson regression analyses were used to examine sex differences in cardiometabolic risk factor levels, treatment, and control.ResultsCompared with men, women had a significantly higher body mass index (BMI) (mean difference 1.79 kg/m2(95% CI 1.49 to 2.08)), while no differences were found in hemoglobin A1c(HbA1c) and systolic blood pressure (SBP). Women had lower diastolic blood pressure (−1.94 mm Hg (95% CI −2.44 to −1.43)), higher total cholesterol (TC) (0.44 mmol/L (95% CI 0.38 to 0.51)), low-density lipoprotein cholesterol (LDL-c) (0.26 mmol/L (95% CI 0.22 to 0.31)), and high-density lipoprotein cholesterol (HDL-c) sex-standardized (0.02 mmol/L (95% CI 0.00 to 0.04)), and lower TC:HDL ratio (−0.29 (95% CI −0.36 to −0.23)) and triglycerides (geometric mean ratio 0.91 (95% CI 0.85 to 0.98)). Women had a 16% higher probability of being treated with antihypertensive medication in the presence of high cardiovascular disease (CVD) risk and elevated SBP than men (relative risk 0.84 (95% CI 0.73 to 0.98)), whereas no sex differences were found for glucose-lowering medication and lipid-modifying medication. Among those treated, women were less likely to achieve treatment targets of HbA1c(0.92 (95% CI 0.87 to 0.98)) and LDL-c (0.89 (95% CI 0.85 to 0.92)) than men, while no differences for SBP were found.ConclusionsIn this Dutch T2D population, women had a slightly different cardiometabolic risk profile compared with men and a substantially higher BMI. Women had a higher probability of being treated with antihypertensive medication in the presence of high CVD risk and elevated SBP than men, and were less likely than men to achieve treatment targets for HbA1cand LDL levels.
Lactational amenorrhoea among adolescent girls in low-income and middle-income countries: a systematic scoping review
Authors: Figaroa Martines N S , Bellizzi Saverio , Delvaux Therese , Benova Lenka 
Published: October 2020

IntroductionFertility levels among adolescents remain high in many settings. The objective of this paper was to review the available literature about postpartum and lactational amenorrhoea among adolescents in low-income and middle-income countries (LMICs).MethodsWe searched Medline, Embase, Global Health and CINAHL Plus databases using terms capturing adolescence and lactational or postpartum amenorrhoea. Inclusion criteria included publication date since 1990, data from LMICs, and topic related to lactational amenorrhoea as a postpartum family planning method or as an effect of (exclusive) breast feeding among adolescents. Thematic analysis and narrative synthesis were applied to summarise and interpret the findings.ResultsWe screened 982 titles and abstracts, reviewed 75 full-text articles and included nine. Eight studies assessed data from a single country (three from India, two from Bangladesh, two from Turkey, one from Nigeria). One study using Demographic and Health Survey data included 37 different LMICs. The five studies measuring duration of postpartum or lactational amenorrhoea reported a wide range of durations across the contexts examined. Four studies (from Bangladesh, Nigeria and Turkey) examined outcomes related to the use of lactational amenorrhoea as a family planning method among adolescents. We did not find any studies assessing adolescents’ knowledge of lactational amenorrhoea as a postpartum family planning method. Likewise, little is known about the effectiveness of lactational amenorrhoea method among adolescents using sufficiently large samples and follow-up time.ConclusionThe available evidence on lactational amenorrhoea among adolescents in LMICs is scarce. Given the potential contribution of lactational amenorrhoea to prevention of short interpregnancy intervals among adolescents and young women, there is a need for a better understanding of the duration of lactational amenorrhoea, and the knowledge and effective use of lactational amenorrhoea method for family planning among adolescents in a wider range of LMIC settings.
Spatial and spatio-temporal methods for mapping malaria risk: a systematic review
Authors: Odhiambo Julius Nyerere , Kalinda Chester , Macharia Peter M , Snow Robert W , Sartorius Benn 
Published: October 2020

BackgroundApproaches in malaria risk mapping continue to advance in scope with the advent of geostatistical techniques spanning both the spatial and temporal domains. A substantive review of the merits of the methods and covariates used to map malaria risk has not been undertaken. Therefore, this review aimed to systematically retrieve, summarise methods and examine covariates that have been used for mapping malaria risk in sub-Saharan Africa (SSA).MethodsA systematic search of malaria risk mapping studies was conducted using PubMed, EBSCOhost, Web of Science and Scopus databases. The search was restricted to refereed studies published in English from January 1968 to April 2020. To ensure completeness, a manual search through the reference lists of selected studies was also undertaken. Two independent reviewers completed each of the review phases namely: identification of relevant studies based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, data extraction and methodological quality assessment using a validated scoring criterion.ResultsOne hundred and seven studies met the inclusion criteria. The median quality score across studies was 12/16 (range: 7–16). Approximately half (44%) of the studies employed variable selection techniques prior to mapping with rainfall and temperature selected in over 50% of the studies. Malaria incidence (47%) and prevalence (35%) were the most commonly mapped outcomes, with Bayesian geostatistical models often (31%) the preferred approach to risk mapping. Additionally, 29% of the studies employed various spatial clustering methods to explore the geographical variation of malaria patterns, with Kulldorf scan statistic being the most common. Model validation was specified in 53 (50%) studies, with partitioning data into training and validation sets being the common approach.ConclusionsOur review highlights the methodological diversity prominent in malaria risk mapping across SSA. To ensure reproducibility and quality science, best practices and transparent approaches should be adopted when selecting the statistical framework and covariates for malaria risk mapping. Findings underscore the need to periodically assess methods and covariates used in malaria risk mapping; to accommodate changes in data availability, data quality and innovation in statistical methodology.
A realist synthesis of quality improvement curricula in undergraduate and postgraduate medical education: what works, for whom, and in what contexts?
Authors: Brown Allison , Lafreniere Kyle , Freedman David , Nidumolu Aditya , Mancuso Matthew , Hecker Kent , Kassam Aliya 
Published: October 2020

BackgroundWith the integration of quality improvement (QI) into competency-based models of physician training, there is an increasing requirement for medical students and residents to demonstrate competence in QI. There may be factors that commonly facilitate or inhibit the desired outcomes of QI curricula in undergraduate and postgraduate medical education. The purpose of this review was to synthesise attributes of QI curricula in undergraduate and postgraduate medical education associated with curricular outcomes.MethodsA realist synthesis of peer-reviewed and grey literature was conducted to identify the common contexts, mechanisms, and outcomes of QI curricula in undergraduate and postgraduate medical education in order to develop a programme theory to articulate what works, for whom, and in what contexts.Results18854 records underwent title and abstract screening, full texts of 609 records were appraised for eligibility, data were extracted from 358 studies, and 218 studies were included in the development and refinement of the final programme theory. Contexts included curricular strategies, levels of training, clinical settings, and organisational culture. Mechanisms were identified within the overall QI curricula itself (eg, clear expectations and deliverables, and protected time), in the didactic components (ie, content delivery strategies), and within the experiential components (eg, topic selection strategies, working with others, and mentorship). Mechanisms were often associated with certain contexts to promote educational and clinical outcomes.ConclusionThis research describes the various pedagogical strategies for teaching QI to medical learners and highlights the contexts and mechanisms that could potentially account for differences in educational and clinical outcomes of QI curricula. Educators may benefit from considering these contexts and mechanisms in the design and implementation of QI curricula to optimise the outcomes of training in this competency area.
Incidence and outcome of myocardial infarction treated with percutaneous coronary intervention during COVID-19 pandemic
Authors: Mohammad Moman A , Koul Sasha , Olivecrona Göran K , Gӧtberg Matthias , Tydén Patrik , Rydberg Erik , Scherstén Fredrik , Alfredsson Joakim , Vasko Peter , Omerovic Elmir , Angerås Oskar , Fröbert Ole , Calais Fredrik , Völz Sebastian , Ulvenstam Anders , Venetsanos Dimitrios , Yndigegn Troels , Oldgren Jonas , Sarno Giovanna , Grimfjärd Per , Persson Jonas , Witt Nils , Ostenfeld Ellen , Lindahl Bertil , James Stefan K , Erlinge David 
Published: October 2020

ObjectiveMost reports on the declining incidence of myocardial infarction (MI) during the COVID-19 have either been anecdotal, survey results or geographically limited to areas with lockdowns. We examined the incidence of MI during the COVID-19 pandemic in Sweden, which has remained an open society with a different public health approach fighting COVID-19.MethodsWe assessed the incidence rate (IR) as well as the incidence rate ratios (IRRs) of all MI referred for coronary angiography in Sweden using the nationwide Swedish Coronary Angiography and Angioplasty Registry (SCAAR), during the COVID-19 pandemic in Sweden (1 March 2020–7 May 2020) in relation to the same days 2015–2019.ResultsA total of 2443 MIs were referred for coronary angiography during the COVID-19 pandemic resulting in an IR 36 MIs/day (204 MIs/100 000 per year) compared with 15 213 MIs during the reference period with an IR of 45 MIs/day (254 MIs/100 000 per year) resulting in IRR of 0.80, 95% CI (0.74 to 0.86), p<0.001. Results were consistent in all investigated patient subgroups, indicating no change in patient category seeking cardiac care. Kaplan-Meier event rates for 7-day case fatality were 439 (2.3%) compared with 37 (2.9%) (HR: 0.81, 95% CI (0.58 to 1.13), p=0.21). Time to percutaneous coronary intervention (PCI) was shorter during the pandemic and PCI was equally performed, indicating no change in quality of care during the pandemic.ConclusionThe COVID-19 pandemic has significantly reduced the incidence of MI referred for invasive treatment strategy. No differences in overall short-term case fatality or quality of care indicators were observed.
Variability in haemoglobin concentration by measurement tool and blood source: an analysis from seven countries
Authors: Rappaport Aviva I , Karakochuk Crystal D , Hess Sonja Y , Whitehead, Jr. Ralph D , Namaste Sorrel M L , Dary Omar , Parker Megan E , Neufeld Lynnette M , Larson Leila M , Newton Sam , Wegmuller Rita , Moorthy Denish 
Published: October 2020

ObjectiveWe explore factors such as the blood sampling site (capillary vs venous), the equipment (HemoCue vs automated haematology analyser) and the model of the HemoCue device (201+ vs 301) that may impact haemoglobin measurements in capillary and venous blood.MethodsEleven studies were identified, and bias, concordance and measures of diagnostic performance were assessed within each study.FindingsOur analysis included 11 studies from seven countries (Cambodia, India, The Gambia, Ghana, Laos, Rwanda and USA). Samples came from children, men, non-pregnant women and pregnant women. Mean bias ranged from −8.7 to 2.5 g/L in Cambodian women, 6.2 g/L in Laotian children, 2.4 g/L in Ghanaian women, 0.8 g/L in Gambian children 6–23 months and 1.4 g/L in Rwandan children 6–59 months when comparing capillary blood on a HemoCue to venous blood on a haematology analyser. Bias was 8.3 g/L in Indian non-pregnant women and 2.6 g/L in Laotian children and women and 1.5 g/L in the US population when comparing capillary to venous blood using a HemoCue. For venous blood measured on the HemoCue compared with the automated haematology analyser, bias was 5.3 g/L in Gambian pregnant women 18–45 years and 11.3 g/L in Laotian children 6–59 months.ConclusionOur analysis found large variability in haemoglobin concentration measured on capillary or venous blood and using HemoCue Hb 201+ or Hb 301 or automated haematology analyser. We cannot ascertain whether the variation is due to differences in the equipment, differences in capillary and venous blood, or factors affecting blood collection techniques.
Efficacy of beveled tip aspiration catheter in mechanical thrombectomy for acute ischemic stroke
Authors: Vargas Jan , Blalock Jonathan , Venkatraman Anand , Anagnostakou Vania , King Robert M , Ewing Joseph A , Gounis Matthew J , Turner Raymond D , Chaudry Imran , Turk Aquilla 
Published: October 2020

BackgroundDirect aspiration thrombectomy techniques use large bore aspiration catheters for mechanical thrombectomy. Several aspiration catheters are now available. We report a bench top exploration of a novel beveled tip catheter and our experience in treating large vessel occlusions (LVOs) using next-generation aspiration catheters.MethodsA retrospective analysis from a prospectively maintained database comparing the bevel shaped tip aspiration catheter versus non-beveled tip catheters was performed. Patient demographics, periprocedural metrics, and discharge and 90-day modified Rankin Scale (mRS) scores were collected. Patients were divided into two groups based on which aspiration catheter was used.ResultsOur data showed no significant difference in age, gender, IV tissue plasminogen activator administration, admission NIH Stroke Scale score, baseline mRS, or LVO location between the beveled tip and flat tip groups. With the beveled tip, Thrombolysis in Cerebral Infarction (TICI) 2C or better recanalization was more frequent overall (93.2% vs 74.2%, p=0.017), stent retriever usage was lower (9.1% vs 29%, p=0.024), and patients had lower mRS on discharge (median 3 vs 4, p<0.001) and at 90 days (median 2 vs 4, p=0.008).ConclusionPatients who underwent mechanical thrombectomy with the beveled tip catheter had a higher proportion of TICI 2C or better and had a significantly lower mRS score on discharge and at 90 days.
Accessing care in multidisciplinary pain treatment facilities continues to be a challenge in Canada
Authors: Choinière Manon , Peng Philip , Gilron Ian , Buckley Norman , Williamson Owen , Janelle-Montcalm Audree , Baerg Krista , Boulanger Aline , Di Renna Tania , Finley Gordon Allen , Intrater Howard , Lau Brenda , Pereira John 
Published: October 2020

Background
Multidisciplinary pain treatment facilities (MPTFs) are considered the optimal settings for the management of chronic pain (CP). This study aimed (1) to determine the distribution of MPTFs across Canada, (2) to document time to access and types of services, and (3) to compare the results to those obtained in 2005–2006.

Methods
This cross-sectional study used the same MPTF definition as in 2005–2006—that is, a clinic staffed with professionals from a minimum of three different disciplines (including at least one medical specialty) and whose services were integrated within the facility. A comprehensive search strategy was used to identify existing MPTFs across Canada. Administrative leads at each MPTF were invited to complete an online questionnaire regarding their facilities.

Results
Questionnaires were completed by 104 MPTFs (response rate 79.4%). Few changes were observed in the distribution of MPTFs across Canada compared with 12 years ago. Most (91.3%) are concentrated in large urban cities. Prince Edward Island and the Territories still lack MPTFs. The number of pediatric-only MPTFs has nearly doubled but remains small (n=9). The median wait time for a first appointment in publicly funded MPTFs is about the same as 12 years ago (5.5 vs 6 months). Small but positive changes were also observed.

Conclusion
Accessibility to public MPTFs continues to be limited in Canada, resulting in lengthy wait times for a first appointment. Community-based MPTFs and virtual care initiatives to distribute pain services into regional and remote communities are needed to provide patients with CP with optimal care.