bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Critical Review of the Enrollment of Black Patients in Cancer Clinical Trials
Authors: Banda Deliya R. , Germain Diane St. , McCaskill-Stevens Worta , Ford Jean G. , Swain Sandra M. 
Published: February 2020

Overview: Although clinical trials represent a vital opportunity for improvements in cancer treatment, data show that a small proportion of patients with newly diagnosed cancer participate in clinical research. Black patients continue to have a worse prognosis for most cancers compared with other patients of other races/ethnicities. Racial/ethnic- and age-related disparities in clinical trial accrual are also well documented. The recruitment and retention of minorities in these trials present an even greater challenge despite regulatory efforts and initiatives to increase representation. Treatment data from homogenous populations prevent us from understanding therapeutic response and the true safety profile of novel therapies. Patient-, physician-, and system-level factors that affect trial participation have been extensively studied. However, years of accrual data remain largely unchanged, suggesting the challenge lies in effectively addressing these factors. Furthermore, data showing that black patients tend to have more advanced stage cancers at the time of diagnosis in fact beg their overrepresentation on clinical trials. An inability to successfully enroll diverse populations in clinical trials only exacerbates racial/ethnic differences in cancer treatment and survivorship.
Development, optimization and validation of an absolute specific assay for active myeloperoxidase (MPO) and its application in a clinical context: role of MPO specific activity in coronary artery disease
Authors: Trentini Alessandro , Rosta Valentina , Spadaro Savino , Bellini Tiziana , Rizzo Paola , Vieceli Dalla Sega Francesco , Passaro Angelina , Zuliani Giovanni , Gentili Valentina , Campo Gianluca , Cervellati Carlo 
Published: February 2020

Abstract

Background
Myeloperoxidase (MPO) is an enzyme with a recognized prognostic role in coronary artery disease (CAD), which is also emerging as a promising biomarker for cardiac risk stratification. However, the lack of a consensus method for its quantification has hindered its implementation in clinical practice. The aim of our work was to optimize an absolute sensitive assay for active MPO without external standards, to validate the method in the clinical context of CAD patients, and to estimate the enzyme specific activity.

Methods
In order to determine the MPO concentration using fluorescence readings, this ELISA assay exploits the activity of the enzyme recognized by specific antibodies. The assay was validated in a small cohort of patients that included: healthy subjects (n=60); patients with acute myocardial infarction (AMI, n=25); patients with stable CAD (SCAD, n=25) and a concomitant chronic obstructive pulmonary disease (COPD). Then, total MPO concentration and specific activity (activity/total MPO) were determined.

Results
The assay showed an intra- and inter-assay coefficient of variation of 5.8% and 10.4%, respectively, with a limit of detection (LoD) of 0.074 μU. Both AMI and SCAD patients had higher active and total MPO than controls (p<0.0001 and p<0.01, respectively). The specific activity of MPO was higher in SCAD patients compared to both controls and AMI (p<0.0001).

Conclusions
The study presents a robust and sensitive method for assaying MPO activity in biological fluids with low variability. Moreover, the determination of the specific activity could provide novel insight into the role of MPO in cardiovascular diseases (CVDs).
Rethinking Cultural Terminology Translation
Authors: Huang Xinyu , Wei Xiangqing , Liu Runze 
Published: February 2020

Abstract
Jakobson’s article “On linguistic aspects of translation” proposes a tripartite division of translation as intralingual, interlingual, and intersemiotic, which offers a panorama of a semiotic approach to translation, especially to what is translation in a multileveled sense. Subsequent scholars develop the two implicit ideas in his article, named by the author as “translation as sign transformation” and “translation as sign interpretation.” While further widening the scope and enriching the perspective of Jakobson’s typology, current literature remains purely theoretical in essence. As a particular research area, cultural terminology translation could serve as the axis linking theory and practice, which becomes the primary concern for this paper. Grounded on a review of Jakobson’s division and related literature in translation semiotics, this study proposes a multileveled understanding of cultural terminology translation based on some concrete cases. Cultural terminology translation is regarded as “sign transformation” and “sign interpretation.” As sign transformation, it concerns the transformation of conceptual, linguistic, and cultural signs, while as sign interpretation, it goes from intralingual to interlingual to intersemiotic interpretation. This research concludes that cultural terminology translation is a complex sign activity calling for further investigations.
On the classification of Schreier extensions of monoids with non-abelian kernel
Authors: Martins-Ferreira Nelson , Montoli Andrea , Patchkoria Alex , Sobral Manuela 
Published: February 2020

Abstract
We show that any regular (right) Schreier extension of a monoid M by a monoid A induces an abstract kernel

Φ
:

M
→

End
⁡

(
A
)

Inn
⁡

(
A
)

{\Phi\colon M\to\frac{\operatorname{End}(A)}{\operatorname{Inn}(A)}}

.
If an abstract kernel factors through

SEnd
⁡

(
A
)

Inn
⁡

(
A
)

{\frac{\operatorname{SEnd}(A)}{\operatorname{Inn}(A)}}

, where

SEnd
⁡

(
A
)

{\operatorname{SEnd}(A)}

is the monoid of surjective endomorphisms of A, then we associate to it an obstruction, which is an element of the third cohomology group of M with coefficients in the abelian group

U
⁢

(

Z
⁢

(
A
)

)

{U(Z(A))}

of invertible elements of the center

Z
⁢

(
A
)

{Z(A)}

of A, on which M acts via Φ.
An abstract kernel

Φ
:

M
→

SEnd
⁡

(
A
)

Inn
⁡

(
A
)

{\Phi\colon M\to\frac{\operatorname{SEnd}(A)}{\operatorname{Inn}(A)}}

(resp.

Φ
:

M
→

Aut
⁡

(
A
)

Inn
⁡

(
A
)

{\Phi\colon M\to\frac{\operatorname{Aut}(A)}{\operatorname{Inn}(A)}}

) is induced by a regular weakly homogeneous (resp. homogeneous) Schreier extension of M by A if and only if its obstruction is zero.
We also show that the set of isomorphism classes of regular weakly homogeneous (resp. homogeneous) Schreier extensions inducing a given abstract kernel

Φ
:

M
→

SEnd
⁡

(
A
)

Inn
⁡

(
A
)

{\Phi\colon M\to\frac{\operatorname{SEnd}(A)}{\operatorname{Inn}(A)}}

(resp.

Φ
:

M
→

Aut
⁡

(
A
)

Inn
⁡

(
A
)

{\Phi\colon M\to\frac{\operatorname{Aut}(A)}{\operatorname{Inn}(A)}}

), when it is not empty, is in bijection with the second cohomology group of M with coefficients in

U
⁢

(

Z
⁢

(
A
)

)

{U(Z(A))}

.
The development of sex differences in humor initiation and appreciation
Authors: Bergen Doris 
Published: February 2020

AbstractBoth common observations and research evidence strongly suggest that there are major differences between adult males and females as to both the number of humorous attempts they display in social situations and the types of humor they initiate and appreciate. What the causes are for these differences, however, have been less clear, with attributions being related to both biological and environmental reasons. In fact, researchers who have studied the development of humor in infants, preschoolers, and elementary age children have generally observed that the early humor of both boys and girls is similar, thus raising the possibility that the differences that gradually emerge with age may be attributed more to environmental rather than to biological reasons. This chapter will discuss the humor research evidence amassed by those who have studied young children’s humor development and the potential environmental influences on humor development that may account for some of the sex differences seen in adult humor.
The traditional sexual script and humor in courtship
Authors: Ross Elaina M. , Hall Jeffrey A. 
Published: February 2020

AbstractTo account for sex differences in the production, receptivity, and preference for humor in potential mates during courtship, past research has often adopted an evolutionary approach. The present manuscript will attempt to integrate evolutionary explanations with proximal social and cultural influences using the traditional sexual script and ambivalent sexism theory. The results of both Study 1 (N=227) and Study 2 (N=424) suggest that trait masculinity is positively associated with humor production in courtship, while trait femininity is associated with humor receptivity. Study 1 indicated that the traditional flirting style was associated with less humor production by women, and Study 2 indicated that hostile sexism was related to a lower preference for a humor-producing potential partner by men. A sex difference in humor production in potential partners in Study 2 was no longer detectable once trait gender and hostile sexism was accounted for. Taken together, gender roles, over and above biological sex, influence one’s own humor use in courtship and preference for humor in potential partners.
Protection Coordination of Radial Distribution Networks Connected with Distributed Generation Considering Auto-reclosing Schemes by Resistive Superconducting Fault Current Limiters
Authors: Hammad Hammad Mahrous , Aly Mohamed M. 
Published: February 2020

AbstractRadial distribution networks are normally protected against fault currents by fuses and reclosers. This protection is coordinated in a way that reclosers clear temporary faults before the melting of fuses and fuses melt to clear permanent faults. Distribution networks, which are recently connected with distributed generations (DGs), incur a variety of issues that are certainly worthy of closer considerations. One of these issues is the operation of protection devices. Recloser-fuse coordination may be lost when DGs are integrated with distribution networks due to the effect of current flowing from DGs during fault period and the breaking of the radiality nature of these networks. The impact of DGs on recloser-fuse coordination depends on penetration level, location, and type of DG. Recloser-fuse coordination of radial distribution networks connected with DGs can be kept by connecting resistive superconducting fault current limiter (R-SFCL) in series with the DG to limit the fault current contribution of DG during the fault period. However, when considering the auto-reclosing scheme of the recloser, recloser-fuse coordination may be lost even if R-SFCL is connected. This paper shows the effectiveness of R-SFCL to restore recloser-fuse coordination without considering auto-reclosing scheme. It also proposes solution methods based on three different configurations of R-SFCL to maintain recloser-fuse coordination when auto-reclosing scheme is considered. Simulation results illustrate the effectiveness of the proposed configurations of R-SFCL to keep recloser-fuse coordination. All simulations are performed using MATLAB/Simulink package.
Individualistic and Structural Explanations in Ásta’sCategories We Live By
Authors: Griffith Aaron M. 
Published: February 2020

AbstractÁsta’sCategories We Live Byis a superb addition to the literature on social metaphysics. In it she offers a powerful framework for understanding the creation and maintenance of social categories. In this commentary piece, I want to draw attention to Ásta’s reliance on explanatory individualism – the view that the social world is best explained by the actions and attitudes of individuals. I argue that this reliance makes it difficult for Ásta to explain how many social categories are maintained and why certain categories are reliably available to us and so resistant to change. These explanatory deficiencies could be overcome, I argue, by eschewing explanatory individualism and positing social structures to figure in structural explanations of the maintenance and availability of social categories.
Crystal structure of (N-benzyl-N-methyl-dithiocarbamato-κ2
S,S′)di(4-chlorobenzyl)chloridotin(IV), C23H22Cl3NS2Sn
Authors: Lo Kong Mun , Mun Lee See , Tiekink Edward R.T. 
Published: February 2020

Abstract
C23H22Cl3NS2Sn, triclinic, P1̄ (no. 2), a = 9.3954(1) Å, b = 10.2747(1) Å, c = 12.8743(2) Å, α = 99.427(1)°, β = 94.247(1)°, γ = 95.817(1)°, V = 1214.51(3) Å3, Z = 2, R
gt(F) = 0.0167, wR
ref(F
2) = 0.0446, T = 100(2) K.
Study of differential transform technique for transient hydromagnetic Jeffrey fluid flow from a stretching sheet
Authors: Kumar Mahesh 
Published: February 2020

AbstractThis article investigates the time-dependent MHD heat transfer flow of Jeffrey fluid from a stretching sheet, the topic significance to non-Newtonian viscoelastic material processing. Using similarity transformations, the governing coupled non-linear PDE’s are remodel into ODE’s with suitable free stream and wall boundary conditions. The developed non-dimensional non-linear problem is revealed to be analysed by several key thermosphysical and rheological parameters, namely, Jeffrey fluid parameter (λ), Deborah number (β), Prandtl number (Pr), buoyancy parameter (ξ), magnetic parameter (M) and unsteadiness parameter (A). The semi-exact differential transform technique is applied to elucidate the coupled nonlinear governing equation of non-Newtonian Jeffrey fluid problem. Also, the solution is validated with numerical results attained via the MATLAB bvp4c function. Excellent accurateness is attained through the DTM approach. Further validation with available consequences from the existing literature is incorporated. The results indicate that fluid velocity and temperature are boosted with increasing Deborah number and stretching parameter however it shows a decreasing trend with Jeffrey fluid parameter and convection parameter. It also shows when augmenting the magnetic parameter which reduces the flow and increases the thickness of the boundary layer.
About classical solutions of the path-dependent heat equation
Authors: Di Girolami Cristina , Russo Francesco 
Published: February 2020

Abstract
This paper investigates two existence theorems for the path-dependent heat equation, which is the Kolmogorov equation related to the window Brownian motion, considered as a

C
⁢

(

[

-
T

,
0
]

)

{C([-T,0])}

-valued process.
We concentrate on two general existence results of its classical solutions related to different classes of terminal conditions: the first one is given by a cylindrical not necessarily smooth random variable, the second one is a smooth generic functional.
One-pot multi-component process for the synthesis of 4-azaphenanthrene-3,10-dione, 1,8-dioxo-octahydroxanthene and tetrahydrobenzo[b]pyran derivatives catalyzed by the deep eutectic solvent choline chloride-oxalic acid
Authors: Sayahi Mohammad Hosein , Gorjizadeh Maryam , Meheiseni Melan , Sayyahi Soheil 
Published: February 2020

Abstract
An effective method based on choline chloride (ChCl)-oxalic acid (Ox) deep eutectic solvent was proposed for the synthesis of 4-azaphenanthrene-3,10-dione, 1,8-dioxo-octahydroxanthene and tetrahydrobenzo[b]pyran derivatives. The eutectic mixture worked as both the solvent and acidic catalyst for conversion. The impacts of different variables, including the composition and volume of ChCl-Ox, and temperature, on reaction yield were studied for optimization. The crucial advantages of this process are simplicity of the experimental procedure, high yields, short reaction times, high recyclability, and the use of safe and inexpensive components.
Mechanical, Structural and Optical Properties of the Silicon Nanowire Arrays
Authors: Muthuvel Ramuvel , Arunachalam Manimaran , Karanthamalai Vinayagar , Venkatesan Ragavendran , Venkatachalapathy Vishnukanthan , Mayandi Jeyanthinath 
Published: February 2020

Abstract
The present work discusses the systematic study of mechanical properties of the silicon nanostructures formed by metal assisted chemical etching (MACE). Silver electrolyte solution, along with hydrogen fluoride, was utilized in formation of silicon nanostructures. An optimized condition of etching time and silver electrolyte concentration were utilized to obtain high aspect ratio, defect-free and high density nanowire arrays on Si wafers. The as-prepared silicon nanostructures (SiNS) were investigated by Scanning electron microscopy (SEM) and nano indentation technique to bring out the morphological and mechanical properties. Further, the variation in optical properties of the bulk silicon and Si nanowire arrays were also investigated to determine the formation of nanostructures.
Wildfires as a Public Health Problem: a Setting for Nursing in Disasters
Authors: Barría P R Mauricio 
Published: February 2020

Climate change and global warming are phenomena that are progressively affecting the planet. Temperature changes have been posing mayor threats for different domains of human society. One of these threats is related to health due extreme temperatures, and natural disasters. Thus, it is constituted as a global threat to biodiversity and the human population, since not only affects ecosystems equilibrium but increasing wildfires as consequence of increased temperaturesand diminished precipitations. Moreover,wildfires have concentrated attention not only because of their ecological and environmental consequences but also for affecting production, economics, and health of people potentially exposed to environmental risks such fire, smoke, and others chemical products released from wood combustion process. How to cite this article: Barría RM. Wildfires as a Public Health Problem: a Setting for Nursing in Disasters. Invest. Educ. Enferm. 2019;37(3):e01.
Use of the Hedgehog signaling pathway inhibitor in the treatment of recurrent locally advanced and metastatic basal cell skin cancer
Authors: Radzhabova Z. A.-G. , Kotov M. A. , Bekyasheva Z. S. , Radzhabova M. A. , Levchenko E. V. 
Published: February 2020

The study objectiveis to provide data on the use of the Hedgehog signaling pathway inhibitor (vismodegib) in the treatment of recurrent locally advanced and metastatic basal cell skin cancer at the N. N. Petrov National Medical Research Center of Oncology.Materials and methods. Clinical data of 10 patients who participated in a multicenter, non-randomized clinical trial of phase II ERIVANCE BBC (ClinicalTrials. gov NCT833417). Patients took the daily studied drug vismodegib orally at a dose of 150 mg daily until disease progression or intolerance due to side effects. Efficiency and safety assessment was carried out once every 4 weeks.Results. Complete regression was achieved in 7 patients, while the average duration of use of the drug was 240 ± 65 days. Stabilization was observed in 2 patients, the minimum duration of the drug was 336 days. One patient showed progression after 728 days of taking the drug. Side effects of the 1 grade according to CTCAE (Common Terminology Criteria for Adverse Events), v. 3.0 were observed in all patients, in 9 they were expressed in muscle cramps, alopecia and changes in taste sensitivity, and in 1 patient isolated in the form of muscle cramps.Conclusion. The results show a good safety profile of vismodegib, which allows it to be used in elderly patients with concomitant pathology. The frequency of response to treatment, including the achievement of complete regression in 70 % of patients, makes vismodegib an acceptable treatment option for metastatic form of basal cell skin cancer and relapse of locally advanced forms.
HUBUNGAN PENGETAHUAN GIZI ORANGTUA DAN PENDAPATAN ORANGTUA DENGAN KEPATUHAN ORANGTUA DALAM PENERAPAN DIET AUTIS PADA ANAK AUTIS DI SLB AUTIS LABORATORIUM UNIVERSITAS NEGERI MALANG
Authors: Handayani Poncowuri , Devi Mazarina , Kurniawan Agung 
Published: February 2020

Abstract: Autism is a behavioral deviation syndrome in children that involves sensory systems, communication skills, and socialization skills in community. Parental obedience in applying the diet should be consistent in order to reduce symptoms are undergone by children with autism. This study aims to determine the relationship between parental nutrition knowledge and parental income to parent’s obedience of complience in the application of autism diet in children with autism in the SLB Autis Laboratorium Malang State University. The type of this research is quantitative research with cross sectional study design. Parental knowledge was measured from a knowledge questionnaire, and income was measured by the per-capita income category per month and parental compliance was measured from Food Frequency Questionare (FFQ). The results showed that there was a significant correlation between parent’s nutritional knowledge and parent’s obedience to the application of the autism diet at SLB Autis Laboratorium Malang State University (p = 0,004) and there was a significant correlation between parent’s income with parent’s obedience to the application of the autism diet at SLB Autis Laboratorium Malang State University (p = 0,020). Suggestions for the next research to conduct more detailed research about per capita income of family by considering another factor.Keywords: knowledge, income, obedience, autism dietAbstrak: Autisme adalah suatu sindroma penyimpangan perilaku pada anak yang melibatkan sistem sensoris, kemampuan komunikasi, serta kemampuan sosialisasi dimasyarakat. Kepatuhan orang tua dalam menerapkan diet harus konsisten agar dapat mengurangi gejala yang dialami oleh anak autis. Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan gizi dan pendapatan orangtua terhadap kepatuhan orangtua dalam penerapan diet autis pada anak autis di SLB Autis Laboratorium Universitas Negeri Malang. Jenis penelitian ini adalah penelitian kuantitatif dengan rancangan penelitian cross sectional. Pengetahuan orangtua diukur dari kuesioner pengetahuan, dan pendapatan diukur berdasarkan kategori pendapatan perkapita keluarga perbulan dan kepatuhan orangtua diukur dari Food Frequency Questionare (FFQ). Hasil penelitian menunjukkan bahwa terdapat hubungan yang signifikan antara pengetahuan gizi orangtua dengan kepatuhan orangtua dalam penerapan diet autis di SLB Autis Laboratorium Universitas Negeri Malang (p=0,004) serta terdapat hubungan yang signifikan antara pendapatan orangtua dengan kepatuhan orangtua dalam penerapan diet autis di SLB Autis Laboratorium Universitas Negeri Malang (p=0,020). Saran bagi peneliti selanjutnya agar melakukan penelitian lebih mendetail lagi mengenai pendapatan perkapita keluarga dan dengan melihat faktor lain. Kata kunci: pengetahuan, pendapatan, kepatuhan, diet autis
Comparative study on data mining techniques used to predict risk of Heart Disease
Authors: Mhatre Tejali Chandrakant , Varma Satishkumar 
Published: February 2020

Heart disease is considered as one of the major causes of death throughout the world. Classification of heart disease can be valuable for medical practitioners to predict disease at early stage. To get accurate result of prediction of disease medical diagnosis system very useful. There are different data mining techniques available to classify medical data related to heart disease. In this paper, survey is carried out to find which are different data mining techniques can be used for heart disease prediction system.