bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interannual monsoon wind variability as a key driver of East African small pelagic fisheries
Authors: Jebri Fatma , Jacobs Zoe L. , Raitsos Dionysios E. , Srokosz Meric , Painter Stuart C. , Kelly Stephen , Roberts Michael J. , Scott Lucy , Taylor Sarah F. W. , Palmer Matthew , Kizenga Hellen , Shaghude Yohana , Wihsgott Juliane , Popova Ekaterina 
Published: August 2020

AbstractSmall pelagic fisheries provide food security, livelihood support and economic stability for East African coastal communities—a region of least developed countries. Using remotely- sensed and field observations together with modelling, we address the biophysical drivers of this important resource. We show that annual variations of fisheries yield parallel those of chlorophyll-a (an index of phytoplankton biomass). While enhanced phytoplankton biomass during the Northeast monsoon is triggered by wind-driven upwelling, during the Southeast monsoon, it is driven by two current induced mechanisms: coastal “dynamic uplift” upwelling; and westward advection of nutrients. This biological response to the Southeast monsoon is greater than that to the Northeast monsoon. For years unaffected by strong El-Niño/La-Niña events, the Southeast monsoon wind strength over the south tropical Indian Ocean is the main driver of year-to-year variability. This has important implications for the predictability of fisheries yield, its response to climate change, policy and resource management.
Zinc-mediated conformational preselection mechanism in the allosteric control of DNA binding to the zinc transcriptional regulator (ZitR)
Authors: He Xinheng , Ni Duan , Zhang Hao , Li Xinyi , Zhang Jian , Fu Qiang , Liu Yaqin , Lu Shaoyong 
Published: August 2020

AbstractThe zinc transcriptional regulator (ZitR) functions as a metalloregulator that fine tunes transcriptional regulation through zinc-dependent DNA binding. However, the molecular mechanism of zinc-driven allosteric control of the DNA binding to ZitR remains elusive. Here, we performed enhanced sampling accelerated molecular dynamics simulations to figure out the mechanism, revealing the role of protein dynamics in the zinc-induced allosteric control of DNA binding to ZitR. The results suggest that zinc-free ZitR samples distinct conformational states, only a handful of which are compatible with DNA binding. Remarkably, zinc binding reduces the conformational plasticity of the DNA-binding domain of ZitR, promoting the population shift in the ZitR conformational ensemble towards the DNA binding-competent conformation. Further co-binding of DNA to the zinc–ZitR complex stabilizes this competent conformation. These findings suggest that ZitR–DNA interactions are allosterically regulated in a zinc-mediated conformational preselection manner, highlighting the importance of conformational dynamics in the regulation of transcription factor family.
Preparation and characterization of diatomite and hydroxyapatite reinforced porous polyurethane foam biocomposites
Authors: Mustafov Sibel Demiroglu , Sen Fatih , Seydibeyoglu M. Ozgur 
Published: August 2020

AbstractPorous three-dimensional (3D) polyurethane-based biocomposites were produced utilizing diatomite and hydroxyapatite as fillers. Diatomite and Hydroxyapatite (HA) were utilized to reinforce the morphological, chemical, mechanical, and thermal properties of polyurethane foam (PUF). Diatomite and Hydroxyapatite were added into polyurethane at variable percentages 0, 1, 2, and 5. The mechanical properties of PUF were analyzed by the compression test. According to the compression test results, the compressive strength of the polyurethane foam is highest in the reinforced foam at 1% by weight hydroxyapatite compared to other reinforced PUFs. Scanning electron microscopy (SEM) images presented structural differences on foam by adding fillers. Functional groups of PUF were defined by Fourier Transform Infrared Spectroscopy (FTIR) and the thermal behavior of PUF was studied with Thermogravimetric Analysis (TGA). The obtained results revealed that PUF/HA biocomposites indicated higher thermal degradation than PUF/Diatomite biocomposites.
Comparison of pediatric and adult medullary thyroid carcinoma based on SEER program
Authors: Zhao Zhuang , Yin Xiang-dang , Zhang Xu-he , Li Zhi-wen , Wang Dun-wei 
Published: August 2020

AbstractTo compare the clinicopathological characteristics and survival outcomes of children and adult diagnosed with medullary thyroid carcinoma (MTC). MTC patients were extracted from the Surveillance, Epidemiology and End Results (SEER) database from 1998 to 2016, followed by stratification into pediatric (< 20 years) or adult (≥ 20 years) groups. In total, 2,197 patients (110 pediatric and 2087 adult) with MTC were identified. Pediatric patients were more likely to have localized stage (70.0% vs. 51.6%), negative regional nodes (48.2% vs. 30.8%) and receive total/subtotal thyroidectomy surgery (97.3% vs. 85.3%). Moreover, CSS and OS rates were significantly higher in pediatric patients (both P < 0.001). Multivariable Cox regression analysis revealed that adult patients were significantly correlated with worse CSS and OS rates [(CSS: HR 11.60, 95% CI 1.62–83.02, P = 0.015); (OS: HR 5.63, 95% CI 2.08–15.25, P = 0.001)]. Further stratified analysis indicated that pediatric group might have significant better CSS and OS for patients with more advanced stage. Patients in the pediatric group were more likely to have earlier stage. Moreover, the prognosis of pediatric MTC patients was significantly better than that in adult patients.
Single-cell analysis of EphA clustering phenotypes to probe cancer cell heterogeneity
Authors: Ravasio Andrea , Myaing Myint Z. , Chia Shumei , Arora Aditya , Sathe Aneesh , Cao Elaine Yiqun , Bertocchi Cristina , Sharma Ankur , Arasi Bakya , Chung Vin Yee , Greene Adrienne C. , Tan Tuan Zea , Chen Zhongwen , Ong Hui Ting , Iyer N. Gopalakrishna , Huang Ruby YunJu , DasGupta Ramanuj , Groves Jay T. , Viasnoff Virgile 
Published: August 2020

AbstractThe Eph family of receptor tyrosine kinases is crucial for assembly and maintenance of healthy tissues. Dysfunction in Eph signaling is causally associated with cancer progression. In breast cancer cells, dysregulated Eph signaling has been linked to alterations in receptor clustering abilities. Here, we implemented a single-cell assay and a scoring scheme to systematically probe the spatial organization of activated EphA receptors in multiple carcinoma cells. We show that cancer cells retain EphA clustering phenotype over several generations, and the degree of clustering reported for migration potential both at population and single-cell levels. Finally, using patient-derived cancer lines, we probed the evolution of EphA signalling in cell populations that underwent metastatic transformation and acquisition of drug resistance. Taken together, our scalable approach provides a reliable scoring scheme for EphA clustering that is consistent over multiple carcinomas and can assay heterogeneity of cancer cell populations in a cost- and time-effective manner.
Gene expression profiling of copper-resistant Caco-2 clones
Authors: O’Doherty Charles , Keenan Joanne , O’Neill Fiona , Clynes Martin , Sinkunaite Indre , Horgan Karina , Murphy Richard , O’Sullivan Finbarr 
Published: August 2020

Abstract
The Caco-2 cell line is composed of a heterogeneous mix of cells; isolation of individual clonal populations from this mix allows for specific mechanisms and phenotypes to be further explored. Previously we exposed Caco-2 cells to inorganic copper sulphate or organic copper proteinate to generate resistant variant populations. Here we describe the isolation and characterisation of clonal subpopulations from these resistant variants to organic (clone Or1, Or2, Or3) or inorganic (clone In1 and In2) copper. The clones show considerable homogeneity in response to Cu-induced toxicity and heterogeneity in morphology with variations in level of cross-resistance to other metals and doxorubicin. Population growth was reduced for Cu-resistant clones In2 and Or3 in selective pressure relative to parental Caco-2 cells. Gene expression analysis identified 4026 total (2102 unique and 1924 shared) differentially expressed genes including those involved in the MAP Kinase and Rap1 signalling pathways, and in the focal adhesion and ECM-receptor contact pathways. Gene expression changes common to all clones included upregulation of ANXA13 and GPx2. Our analysis additionally identified differential expression of multiple genes specific to copper proteinate exposure (including overexpressed UPK1B) in isolated clones Or1, Or2 and Or3 and CuSO4 exposure (including decreased AIFM2 expression) in isolated clones In1 and In2. The adaptive transcriptional responses established in this study indicate a cohort of genes, which may be involved in copper resistance regulation and chronic copper exposure.
Speech Prosody Interventions for Persons With Autism Spectrum Disorders: A Systematic Review
Authors: Holbrook Sarai , Israelsen Megan 
Published: August 2020

PurposePersons with autism spectrum disorder (ASD) may demonstrate abnormal prosodic patterns in conversational speech, which can negatively affect social interactions. The purpose of this systematic review was to identify interventions measuring the improvement of expressive speech prosody in persons with ASD in order to support clinician's evidence-based decision making.MethodWe used 13 electronic databases to search for relevant articles using terms related to autism, intervention, and speech prosody. The databases identified a total of nine articles for the title, abstract, and full-text reviews. Five more articles were included after performing descendant and reference searches. One peer-reviewed article was excluded due to insufficient data received from the authors. We coded the resulting 13 articles for report, setting, intervention, outcome, and results characteristics and methodological quality.ResultsResults showed that interventions specifically targeting speech prosody using established and emerging evidence-based practices across more than 1 treatment day resulted in moderate to large improvements in speech prosody in persons with ASD. Interventions that indirectly targeted prosody or were very short resulted in small or nonsignificant effects.DiscussionThe results of this literature review suggest that interventions that directly target speech prosody using established evidence-based practices for ASD may be most effective for increasing typical prosodic patterns during speech for persons with ASD. Further research is needed to establish which interventions are most effective for each age range and context.Supplemental Materialhttps://doi.org/10.23641/asha.12735926
Developing Evidence-Based Assessment to Prevent Over- or Underidentification of Disorders for New Language Learners
Authors: Levey Sandra , Cheng Li-Rong Lilly , Almodovar Diana 
Published: August 2020

Purpose
The purpose of this review article is to present certain linguistic domains to consider in the assessment of children learning a new language. Speech-language pathologists frequently face difficulty when determining if a bilingual or multilingual child possesses a true speech or language disorder. Given the increased number of new language learners across the world, clinicians must understand differences versus disorders to prevent underidentification or overidentification of a disorder.

Conclusions
Early identification of a true disorder has been shown to prevent language and literacy difficulties, given that children are able to achieve grade-level reading skills when given intervention. Clinical knowledge and skills are strongly required so that children receive evidence-based assessment to support their academic development.

Learning Goal
Readers will gain an understanding of the factors that support evidence-based assessment of bilingual and multilingual language learners.
Linking ice and gas in the Serpens low-mass star-forming region
Authors: Perotti G. , Rocha W. R. M. , Jørgensen J. K. , Kristensen L. E. , Fraser H. J. , Pontoppidan K. M. 
Published: August 2020

Context. The interaction between dust, ice, and gas during the formation of stars produces complex organic molecules. While observations indicate that several species are formed on ice-covered dust grains and are released into the gas phase, the exact chemical interplay between solid and gas phases and their relative importance remain unclear.
Aims. Our goal is to study the interplay between dust, ice, and gas in regions of low-mass star formation through ice- and gas-mapping and by directly measuring gas-to-ice ratios. This provides constraints on the routes that lead to the chemical complexity that is observed in solid and gas phases.
Methods. We present observations of gas-phase methanol (CH3OH) and carbon monoxide (13CO and C18O) at 1.3 mm towards ten low-mass young protostars in the Serpens SVS 4 cluster from the SubMillimeter Array (SMA) and the Atacama Pathfinder EXperiment (APEX) telescope. We used archival data from the Very Large Telescope (VLT) to derive abundances of ice H2O, CO, and CH3OH towards the same region. Finally, we constructed gas-ice maps of SVS 4 and directly measured CO and CH3OH gas-to-ice ratios.
Results. The SVS 4 cluster is characterised by a global temperature of 15 ± 5 K. At this temperature, the chemical behaviours of CH3OH and CO are anti-correlated: larger variations are observed for CH3OH gas than for CH3OH ice, whereas the opposite is seen for CO. The gas-to-ice ratios (Ngas/Nice) range from 1–6 for CO and 1.4 × 10−4–3.7 × 10−3 for CH3OH. The CO gas-maps trace an extended gaseous component that is not sensitive to the effect of freeze-out. Because of temperature variations and dust heating around 20 K, the frozen CO is efficiently desorbed. The CH3OH gas-maps, in contrast, probe regions where methanol is predominantly formed and present in ices and is released into the gas phase through non-thermal desorption mechanisms.
Conclusions. Combining gas- and ice-mapping techniques, we measure gas-to-ice ratios of CO and CH3OH in the SVS 4 cluster. The CH3OH gas-to-ice ratio agrees with values that were previously reported for embedded Class 0/I low-mass protostars. We find that there is no straightforward correlation between CO and CH3OH gas with their ice counterparts in the cluster. This is likely related to the complex morphology of SVS 4: the Class 0 protostar SMM 4 and its envelope lie in the vicinity, and the outflow associated with SMM 4 intersects the cluster. This study serves as a pathfinder for future observations with ALMA and the James Webb Space Telescope (JWST) that will provide high-sensitivity gas-ice maps of molecules more complex than methanol. Such comparative maps will be essential to constrain the chemical routes that regulate the chemical complexity in star-forming regions.
Binary asteroid (31) Euphrosyne: ice-rich and nearly spherical
Authors: Yang B. , Hanuš J. , Carry B. , Vernazza P. , Brož M. , Vachier F. , Rambaux N. , Marsset M. , Chrenko O. , Ševeček P. , Viikinkoski M. , Jehin E. , Ferrais M. , Podlewska-Gaca E. , Drouard A. , Marchis F. , Birlan M. , Benkhaldoun Z. , Berthier J. , Bartczak P. , Dumas C. , Dudziński G. , Ďurech J. , Castillo-Rogez J. , Cipriani F. , Colas F. , Fetick R. , Fusco T. , Grice J. , Jorda L. , Kaasalainen M. , Kryszczynska A. , Lamy P. , Marciniak A. , Michalowski T. , Michel P. , Pajuelo M. , Santana-Ros T. , Tanga P. , Vigan A. , Witasse O. 
Published: August 2020

Aims. Asteroid (31) Euphrosyne is one of the biggest objects in the asteroid main belt and it is also the largest member of its namesake family. The Euphrosyne family occupies a highly inclined region in the outer main belt and contains a remarkably large number of members, which is interpreted as an outcome of a disruptive cratering event.
Methods. The goals of this adaptive-optics imaging study are threefold: to characterize the shape of Euphrosyne, to constrain its density, and to search for the large craters that may be associated with the family formation event.
Results. We obtained disk-resolved images of Euphrosyne using SPHERE/ZIMPOL at the ESO 8.2 m VLT as part of our large program (ID: 199.C-0074, PI: Vernazza). We reconstructed its 3D shape via the ADAM shape modeling algorithm based on the SPHERE images and the available light curves of this asteroid. We analyzed the dynamics of the satellite with the Genoid meta-heuristic algorithm. Finally, we studied the shape of Euphrosyne using hydrostatic equilibrium models.
Conclusions. Our SPHERE observations show that Euphrosyne has a nearly spherical shape with the sphericity index of 0.9888 and its surface lacks large impact craters. Euphrosyne’s diameter is 268 ± 6 km, making it one of the top ten largest main belt asteroids. We detected a satellite of Euphrosyne – S/2019 (31) 1 – that is about 4 km across, on a circular orbit. The mass determined from the orbit of the satellite together with the volume computed from the shape model imply a density of 1665 ± 242 kg m−3, suggesting that Euphrosyne probably contains a large fraction of water ice in its interior. We find that the spherical shape of Euphrosyne is a result of the reaccumulation process following the impact, as in the case of (10) Hygiea. However, our shape analysis reveals that, contrary to Hygiea, the axis ratios of Euphrosyne significantly differ from those suggested by fluid hydrostatic equilibrium following reaccumulation.
Atmospheric NLTE models for the spectroscopic analysis of blue stars with winds
Authors: Puls J. , Najarro F. , Sundqvist J. O. , Sen K. 
Published: August 2020

Context. Obtaining precise stellar and wind properties and abundance patterns of massive stars is crucial to understanding their nature and interactions with their environments, as well as to constrain their evolutionary paths and end-products.
Aims. To enable higher versatility and precision of the complete ultraviolet (UV) to optical range, we improve our high-performance, unified, NLTE atmosphere and spectrum synthesis code FASTWIND. Moreover, we aim to obtain an advanced description of X-ray emission from wind-embedded shocks, consistent with alternative modeling approaches.
Methods. We include a detailed comoving frame radiative transfer for the essential frequency range, but still apply methods that enable low turnaround times. We compare the results of our updated computations with those from the alternative code CMFGEN, and our previous FASTWIND version, for a representative model grid.
Results. In most cases, our new results agree excellently with those from CMFGEN, both regarding the total radiative acceleration, strategic optical lines, and the UV-range. Moderate differences concern He II λλ4200-4541 and N V λλ4603-4619. The agreement regarding N III λλ4634−4640−4642 has improved, though there are still certain discrepancies, mostly related to line overlap effects in the extreme ultraviolet, depending on abundances and micro-turbulence. In the UV range of our coolest models, we find differences in the predicted depression of the pseudo-continuum, which is most pronounced around Lyα. This depression is larger in CMFGEN, and related to different Fe IV atomic data. The comparison between our new and previous FASTWIND version reveals an almost perfect agreement, except again for N V λλ4603-4619. Using an improved, depth-dependent description for the filling factors of hot, X-ray emitting material, we confirm previous analytic scaling relations with our numerical models.
Conclusions. We warn against uncritically relying on transitions, which are strongly affected by direct or indirect line-overlap effects. The predicted UV-continuum depression for the coolest grid-models needs to be checked, both observationally, and regarding the underlying atomic data. Wind lines from “super-ionized” ions such as O VI can, in principle, be used to constrain the distribution of wind-embedded shocks. The new FASTWIND version v11 is now ready to be used.
Ubiquitous hundred-Gauss magnetic fields in solar spicules
Authors: Kriginsky M. , Oliver R. , Freij N. , Kuridze D. , Asensio Ramos A. , Antolin P. 
Published: August 2020

Aims. We aim to study the magnetic field in solar spicules using high-resolution spectropolarimetric observations in the Ca II 8542 Å line obtained with the Swedish 1-m Solar Telescope.
Methods. The equations that result from the application of the weak field approximation (WFA) to the radiative transfer equations were used to infer the line-of-sight (LOS) component of the magnetic field (BLOS). Two restrictive conditions were imposed on the Stokes I and V profiles at each pixel before they could be used in a Bayesian inversion to compute its BLOS.
Results. The LOS magnetic field component was inferred in six data sets totalling 448 spectral scans in the Ca II 8542 Å line and containing both active region and quiet Sun areas, with values of hundreds of Gauss being abundantly inferred. There seems to be no difference, from a statistical point of view, between the magnetic field strength of spicules in the quiet Sun or near an active region. On the other hand, the BLOS distributions present smaller values on the disc than off-limb, a fact that can be explained by the effect of superposition on the chromosphere of on-disc structures. We show that on-disc pixels in which the BLOS is determined are possibly associated with spicular structures because these pixels are co-spatial with the magnetic field concentrations at the network boundaries and the sign of their BLOS agrees with that of the underlying photosphere. We find that spicules in the vicinity of a sunspot have a magnetic field polarity (i.e. north or south) equal to that of the sunspot. This paper also contains an analysis of the effect of off-limb overlapping structures on the observed Stokes I and V parameters and the BLOS obtained from the WFA. It is found that this value is equal to or smaller than the largest LOS magnetic field components of the two structures. In addition, using random BLOS, Doppler velocities, and line intensities of these two structures leads in ≃50% of the cases to Stokes I and V parameters that are unsuitable to be used with the WFA.
Conclusions. Our results present a scarcity of LOS magnetic field components smaller than some 50 G, which must not be taken as evidence against the existence of these magnetic field strengths in spicules. This fact possibly arises as the consequence of signal superposition and noise in the data. We also suggest that the failure of previous works to infer the strong magnetic fields in spicules detected here is their coarser spatial and/or temporal resolution.