bluuebunny/crossref_metadata_2025_split huggingface dataset:
Personalized medicine, digital technology and trust: a Kantian account
Authors: Myskja Bjørn K. , Steinsbekk Kristin S. 
Published: September 2020

Abstract
Trust relations in the health services have changed from asymmetrical paternalism to symmetrical autonomy-based participation, according to a common account. The promises of personalized medicine emphasizing empowerment of the individual through active participation in managing her health, disease and well-being, is characteristic of symmetrical trust. In the influential Kantian account of autonomy, active participation in management of own health is not only an opportunity, but an obligation. Personalized medicine is made possible by the digitalization of medicine with an ensuing increased tailoring of diagnostics, treatment and prevention to the individual. The ideal is to increase wellness by minimizing the layer of interpretation and translation between relevant health information and the patient or user. Arguably, this opens for a new level of autonomy through increased participation in treatment and prevention, and by that, increased empowerment of the individual. However, the empirical realities reveal a more complicated landscape disturbed by information ‘noise’ and involving a number of complementary areas of expertise and technologies, hiding the source and logic of data interpretation. This has lead to calls for a return to a mild form of paternalism, allowing expertise coaching of patients and even withholding information, with patients escaping responsibility through blind or lazy trust. This is morally unacceptable, according to Kant’s ideal of enlightenment, as we have a duty to take responsibility by trusting others reflexively, even as patients. Realizing the promises of personalized medicine requires a system of institutional controls of information and diagnostics, accessible for non-specialists, supported by medical expertise that can function as the accountable gate-keeper taking moral responsibility required for an active, reflexive trust.
Massive pulmonary embolism in patients with extreme bleeding risk: a case series on the successful use of ultrasound-assisted, catheter directed thrombolysis in a district general hospital
Authors: He Jingzhou , Clayton Benjamin , Kurdi Hibba , Gibbons Michael , Watkinson Anthony , Sharp Andrew S. P. 
Published: September 2020

AbstractMassive pulmonary embolism (PE), characterised by profound arterial hypotension, is a life-threatening emergency with a 90-day mortality of over 50%. Systemic thrombolysis can significantly reduce the risk of death or cardiovascular collapse in these patients, by around 50%, but these benefits are offset by a fivefold increased risk of intracranial haemorrhage and major bleeding, which may limit its use in patients at high risk of catastrophic haemorrhage. We describe a case series of 3 patients presenting with massive PE, each with extreme risk of bleeding and contra-indication to systemic thrombolysis, treated successfully with ultrasound-assisted, catheter directed thrombolysis (U-ACDT). Our experience of this novel technique using the EkoSonic Endovascular System (Ekos, BTG, London, UK) on carefully selected patients has demonstrated the potential to improve clinical status in shocked patients, with minimal bleed risk. There have been several clinical studies evaluating the Ekos system. Both the ULTIMA and SEATTLE II studies have shown significant reductions in RV/LV ratio by CT scanning when compared to standard anticoagulation in patients with intermediate-risk PE, with minimal bleeding complications. However, there is a pressing need for a randomised trial demonstrating improvement in robust clinical outcomes when comparing U-ACDT to simple anticoagulation. We believe that this case series adds new insight and highlights the potential of catheter directed thrombolysis in this high-risk patient cohort and consideration should be made to its use in cases where systemic thrombolysis is felt to be too high risk.
Examining my-side bias during and after reading controversial historical accounts
Authors: Iordanou Kalypso , Kendeou Panayiota , Zembylas Michalinos 
Published: September 2020

AbstractThe present study examines individuals’ thinking during and after reading controversial historical accounts and the possible contribution of epistemic beliefs, emotions, and prior-knowledge in this context. Young adults (n = 39) were asked to read two accounts about a recent war in their country, an own-side account – from a historian of their ethnic group – and an other-side account – from a historian from the adversary ethnic group. Participants were asked to think-aloud and report their emotions during reading. After reading, participants were asked to write a summary. Results showed that participants exhibited my-side bias during reading and writing, while there were also interesting individual differences in epistemic beliefs and prior knowledge. Participants with evaluativist epistemic beliefs were less likely to show my-side bias in the writing task. Epistemic beliefs, along with prior knowledge and the emotion of anger, predicted also low-epistemic processing during reading of other-side text. The paper concludes with a discussion of the educational implications in promoting critical thinking about controversial issues in history.
Capturing teaching practices in language-responsive mathematics classrooms Extending the TRU framework “teaching for robust understanding” to L-TRU
Authors: Prediger Susanne , Neugebauer Philipp 
Published: September 2020

AbstractSupporting language in mathematics classrooms requires both curriculum material that follows language-responsive design principles and teaching practices that enact these principles with high instructional quality. This paper presents the analytic framework L-TRU, which was developed to assess language-responsive teaching practices quantitatively. The L-TRU framework draws upon Schoenfeld’s teaching for robust understanding (TRU) framework by adapting its five dimensions to language-responsive classrooms: Mathematical Richness, Cognitive Demand, Equitable Access, Agency, and Use of Student Contributions. It is extended by two further dimensions, namely, Discursive Demand and Connecting Registers. The adapted and extended L-TRU rating scheme was applied to 41 video-recorded lessons of 26 teachers who all used the same language-responsive curriculum material on percentages. The qualitative insights gained from selected transcripts reveal that the dimensions indeed capture important distinctions in valid ways. The analysis of interrater reliability and correlations confirms that distinct dimensions are captured with reliability. The quantitative overview of the ratings of 497 episodes shows that in spite of the shared curriculum material, a large variety of instructional practices were enacted: Consistently high quality was found in the dimensions Cognitive Demand and Equitable Access and a medium quality in Connecting Registers. The dimensions Agency, Discursive Demand and Use of Contributions show the largest variance among teachers, with Discursive Demand separating most. These findings empirically substantiate an important research tool for quantitatively capturing teaching practices with respect to their general mathematics instruction quality and language-responsive quality.
Prevalence of germline TP53 variants among early-onset breast cancer patients from Polish population
Authors: Rogoża-Janiszewska Emilia , Malińska Karolina , Górski Bohdan , Scott Rodney J. , Cybulski Cezary , Kluźniak Wojciech , Lener Marcin , Jakubowska Anna , Gronwald Jacek , Huzarski Tomasz , Lubiński Jan , Dębniak Tadeusz 
Published: September 2020

Abstract
Background
The objective of this study was to determine spectrum and prevalence of germline mutations in TP53 gene among Polish women with early-onset breast cancer (BC), which has not been determined until now.

Methods
A cohort of 100 females with BC diagnosed ≤ 30 years of age and with a positive family history of cancer was used as a discovery cohort. 1880 women with BC ≤ 45 years old and a control group of 2000 healthy women were genotyped as a replication phase of this study.

Results
Four heterozygous pathogenic missense mutations were detected in a group of 100 patients with early-onset breast cancer. On the basis of software prediction and available literature data, all these variants were defined as pathogenic. None of these TP53 variants were detected among 1880 breast cancer patients and 2000 healthy controls. No large mutations were found among early-onset cases using MLPA reaction.

Conclusion
Germline pathogenic TP53 variants were found in 4% early-onset Polish BC patients. No founder mutations were identified in Polish population. To improve the treatment and surveillance screening, the search for germline TP53 pathogenic variants is recommended for all female BC cases diagnosed ≤ 30 years old.
SIUMB recommendations for focal pancreatic lesions
Authors: D’Onofrio Mirko , de Sio Ilario , Mirk Paoletta , Vidili Gianpaolo , Bertolotto Michele , Cantisani Vito , Schiavone Cosima ,   The SIUMB experts committee, Accogli Esterita , Attili Fabia , Basilico Raffaella , Bertolotto Michele , Brizi M. Gabriella , Buscarini Elisabetta , Caiazzo Corrado , Calliada Fabrizio , Cantisani Vito , Carriero Alessandro , Casadei Alder , Catalano Orlando , D’Anneo Gaspare , De Prizio Marco , de Sio Ilario , Di Candio Giulio , D’Onofrio Mirko , Draghi Ferdinando , Drudi Francesco Maria , Ferraioli Giovanna , Francica Giampiero , Granata Antonio , Iannetti Giovanni , Maconi Giovanni , Magnolfi Fabrizio , Mirk Paoletta , Piscaglia Fabio , Pompili Maurizio , Rapaccini Gian Ludovico , Schiavone Cosima , Sconfienza Luca Maria , Serra Carla , Soresi Maurizio , Speca Stefania , Stramare Roberto , Tarantino Luciano , Valentino Massimo , Vallone Gianfranco , Vidili Gianpaolo 
Published: September 2020

AbstractContrast-enhanced ultrasonography (CEUS) is increasingly being performed in Italy and Europe, particularly in the field of hepato-gastroenterology. Initially, it was mainly carried out to characterize focal hepatic lesions, but, since then, numerous studies have demonstrated its efficacy in the differential diagnosis of focal pancreatic pathologies (D’Onofrio et al. in Expert Rev Med Devices 7(2):257–273, 2010; Vidili et al. in J Ultrasound 22(1):41–51, 2019). The purpose of this paper is to provide Italian Medical Doctors with recommendations and thereby practical guidelines on the management of these patients. The present paper reports the final conclusions reached by the SIUMB guideline commission. This paper addresses particularly percutaneous ultrasound (US) examination (transabdominal US) and is drawn up specifically for publication.
Multifaceted Bioinspiration for Improving the Shaft Resistance of Deep Foundations
Authors: Aleali Seyed Ali , Bandini Paola , Newtson Craig Michael 
Published: September 2020

AbstractThis paper describes the bioinspiration process to derive design concepts for new deep foundation systems that have greater axial capacity per unit volume of pile material compared to conventional deep foundations. The study led to bioinspired ideas that provide greater load capacity by increasing the pile shaft resistance. The bioinspiration approach used problem-solving strategies to define the problem and transfer strategies from biology to geotechnical engineering. The bioinspiration considered the load transfer mechanism of hydroskeletons and the anchorage of the earthworm, razor clam, kelp, and lateral roots of plants. The biostrategies that were transferred to the engineering domain included a flexible but incompressible core, passive behaviour against external loading, a longitudinally split shell that allows expansion for anchorage, and lateral root-type or setae-type anchoring elements. The concepts of three bioinspired deep foundation systems were proposed and described. The advantage of this approach was illustrated with two examples of the new laterally expansive pile in drained sand under axial compression. The finite element analysis of these examples showed that the new laterally expansive pile can provide considerably greater load capacity compared to a conventional cylindrical pile due to the increased lateral confining pressure developed along the expanded pile core.
Marine Envenomation
Authors: Hifumi Toru , Fukuchi Yoshimune , Otani Norio 
Published: September 2020

AbstractWith global warming and an increasing frequency of human interaction with venomous marine organisms, physicians are likely to encounter more cases of marine envenomation in clinical practice in Japan and around the world. Few review articles regarding the clinical characteristics of marine envenomation have been published and there has been no comprehensive review of available antivenoms, which are the definitive treatment. We discuss the epidemiology, venom activity, clinical symptoms, diagnosis, and treatment of marine envenomation by the Okinawan box jellyfish, stonefish, Portuguese man-of-war, geography cone, and blue-ringed octopus. A comprehensive review of available antivenom treatments is also presented.
Stochastically modeled weakly reversible reaction networks with a single linkage class
Authors: Anderson David F. , Cappelletti Daniele , Kim Jinsu 
Published: September 2020

AbstractIt has been known for nearly a decade that deterministically modeled reaction networks that are weakly reversible and consist of a single linkage class have trajectories that are bounded from both above and below by positive constants (so long as the initial condition has strictly positive components). It is conjectured that the stochastically modeled analogs of these systems are positive recurrent. We prove this conjecture in the affirmative under the following additional assumptions: (i) the system is binary, and (ii) for each species, there is a complex (vertex in the associated reaction diagram) that is a multiple of that species. To show this result, a new proof technique is developed in which we study the recurrence properties of the n-step embedded discrete-time Markov chain.
Organic food consumption and gluten-free diet, is there a link? Results in French adults without coeliac disease
Authors: Perrin Laëtitia , Allès Benjamin , Julia Chantal , Hercberg Serge , Touvier Mathilde , Lairon Denis , Baudry Julia , Kesse-Guyot Emmanuelle 
Published: September 2020

AbstractThe rising popular belief that gluten is unhealthy has led to growth in gluten avoidance in people without coeliac disease. Little information is available on their dietary profiles and their dietary behaviours. Our aim was to compare the consumption of organic foods between gluten avoiders and non-avoiders, and their places of food purchase. We described their sociodemographic and dietary profiles. The study population included participants of the NutriNet-Santé cohort who completed both a food exclusion questionnaire and an organic semi-quantitative FFQ (n 23 468). Food intake and organic food consumption ratios were compared using multivariable adjusted ANCOVA models. Associations between gluten avoidance and organic food consumption as well as places of food purchase were investigated with multivariable logistic regression. Participants avoiding gluten were more likely to be women and had a healthier dietary profile. Organic food consumption was higher among gluten avoiders (48·50 % of total diet for total avoiders, 17·38 % for non-avoiders). After adjustments for confounders, organic food consumption and purchase in organic stores were positively associated with gluten avoidance: adjusted OR (aOR)Q5 v.Q1 organic food = 4·95; 95 % CI 3·70, 6·63 and aORorganic stores v.supermarkets = 1·82; 95 % CI 1·42, 2·33 for total avoiders. Our study highlights that individuals avoiding gluten are high organic consumers and frequently purchase their foods in organic stores which propose an extended offer of gluten-free food. Further research is needed to determine the underlying common motivations and the temporality of the dietary behaviours of healthy people avoiding gluten.
In siturare earth element analysis of a lower Cambrian phosphate nodule by LA-ICP-MS
Authors: Ye Yun-Tao , Wang Hua-Jian , Wang Xiao-Mei , Zhai Li-Na , Wu Chao-Dong , Zhang Shui-Chang 
Published: September 2020

AbstractRare earth elements (REE) in marine minerals have been widely used as proxies for the redox status of depositional and/or diagenetic environments. Phosphate nodules, which are thought to grow within decimetres below the sediment–water interface and to be able to scavenge REE from the ambient pore water, are potential archives of subtle changes in REE compositions. Whether their REE signals represent specific redox conditions or they can be used to track the overlying water chemistry is worth exploring. Throughin situlaser ablation – inductively coupled plasma – mass spectrometry (LA-ICP-MS), we investigate the REE compositions of a drill-core-preserved phosphate nodule from the lower Cambrian Niutitang Formation in the Daotuo area, northeastern Guizhou Province, South China. REE distributions of the nodule show concentric layers with systematic decreases in Ce anomalies (Ce/Ce*) from the core to the rim. The lowest Ce/Ce* appears in the outer rim where REE concentrations are relatively high. These results are interpreted to reflect REE exchange with pore water at a very early stage or bathymetric variation during apatite precipitation. The origin of the shale-normalized middle REE (MREE) enrichment in our sample is less constrained. Possible driving factors include preferential MREE substitution for Ca in the apatite lattice, degradation of organic matter and deposition beneath a ferruginous zone. Although speculative, the last possibility is consistent with the chemically stratified model for early Cambrian oceans, in which dynamic fluctuations of the chemocline provided an ideal depositional context for phosphogenesis.
U–Pb detrital zircon ages from Gorgoglione Flysch sandstones in Southern Apennines (Italy) as provenance indicators
Authors: Fornelli Annamaria , Gallicchio Salvatore , Micheletti Francesca , Langone Antonio 
Published: September 2020

AbstractTwenty-one sandstone samples belonging to the intermediate part of Gorgoglione Flysch (GF) dated Middle-Miocene, cropping out in the Southern Apennines (Italy), have been studied to highlight the detritus provenance. Petrographic and chemical composition indicates that the successions consist of feldspatho-quartzose and litho-feldspatho-quartzose arenites interbedded with pelitic and calciclastic layers and reveals a provenance from a basement formed by low- to medium-grade metamorphic rocks with abundant granitoids covered by sedimentary rocks in which a volcanic component was also present. In the Mediterranean area, basements with these characteristics are widespread both in western and southwestern domains. The supply provenance of Gorgoglione Flysch has been better detailed utilizing U–Pb detrital zircon ages recording the geological history of the source rocks. Fifty-eight crystals from six samples of coarse- and fine-grained sandstones have been analysed using the U–Pb isotopic systematic (LA-ICP-MS). They produce 70 concordant zircon ages forming three defined clusters at 672 ± 28 Ma, 458 ± 9 Ma and 297 ± 8 Ma, and four zircon ages corresponding to 24 ± 1 Ma. An evaluation of the entire collected data suggests that the provenance area is better identified in northwestern sectors of the Mediterranean area in which the Sardinia–Corsica (pro-part) block plays a fundamental role.
Predicting milk yield in Pelibuey ewes from the udder volume measurement with a simple method
Authors: Espinosa-Mendoza Roger Iván , Arcos-Álvarez Darwin Nicolas , Garcia-Herrera Ricardo Alfonso , Antonio-Molina Gamaliel , Vicente-Pérez Ricardo , Macias-Cruz Ulises , Ronquillo Manuel González , Chaparro Augusto Cesar Lizarazo , Chay-Canul Alfonso Juventino 
Published: September 2020

AbstractIn this research communication we describe the creation of an equation for the prediction of milk yield (MY) from udder volume (UV). A total of 280 measurements were collected between 5 and 15 d postpartum (pp) from 36 multiparous Pelibuey ewes. Study variables were measured between 2 and 9 weeks pp and MY was measured by manual milking, UV prior to and following milking was measured using the technique of making moulds from aluminium foil. The MY ranged from 0.09 to 0.83 kg/d, meanwhile UV prior and following milking ranged from 155 to 1940 and 90 to 1520 cm3, respectively. Measurements of UV had a moderate to high (P < 0.01; 0.58 ≤ r ≤ 0.78) correlation with MY. The UV prior to milking was the best prediction model for MY, which explained 62% of the variation in MY. This equation presented moderate precision (r2 = 0.61) and high accuracy (bias correction factor = 0.94), confirming a good reproducibility index (concordance correlation coefficient = 0.73). Modelling efficiency (MEF = 0.59) showed moderate concordance between observed and predicted values. In conclusion, MY in lactating Pelibuey ewes could be predicted in a moderate way using the predictor variable UV measured with the technique of moulds made with aluminium foil.
Optimisation of spray drying process in microencapsulated cream powder production
Authors: Himmetagaoglu Ahsen Burcin , Berktas Serap , Cam Mustafa , Erbay Zafer 
Published: September 2020

AbstractIn this Research Communication we describe the optimisation of spray drying conditions in the production of microencapsulated cream powder. Oil-in-water emulsions were prepared using maltodextrin (18 DE) and sodium caseinate as wall materials (with the total wall material per total solid content ratio of 30%) and then converted into powder by spray drying. Response surface methodology was used to optimise the factors of spray drying system i.e. inlet drying temperature, feed flow rate, and aspiration rate, where the levels were in the range of 150–190°C, 9–30 ml/min, and 50–100%, respectively. Our objective was to perform spray drying with the highest drying yield and to obtain a microencapsulated cream powder with the highest bulk density, the shortest wetting time, and the lowest surface fat content. The calculated and validated optimum conditions for the spray drying process were found to be 162.8°C for inlet drying temperature, 11.51 ml/min for feed flow rate, and 72.8% for aspiration rate. At these optimum conditions, drying yield, bulk density, wettability, and surface fat content values were 36.37%, 269.9 kg/m3, 115.2 s and 26.2%, respectively.