bluuebunny/crossref_metadata_2025_split huggingface dataset:
A fish oil-rich diet leads to lower adiposity and serum triglycerides but increases liver lipid peroxidation in fructose-fed rats
Authors: Esteves Gabriel Perri , Manca Camila Sanches , Veida-Silva Hellen Paraguassú , Ovidio Paula Payão , Holland Héric , Matsuo Flávia Sayuri , Osako Mariana Kiomy , Jordao Alceu Afonso 
Published: September 2020

Abstract
Background
Consumption of refined carbohydrates has risen in recent years alongside chronic diseases such as type 2 diabetes mellitus, dyslipidemia, obesity, and non-alcoholic fatty liver disease (NAFLD). Fructose is a monosaccharide made widely available in industrialized products, capable of inducing excessive weight gain and liver steatosis in animal models, while omega-3 fatty acids, present in foods such as fatty fish and fish oil, have shown to inhibit genes related to lipogenesis and decrease cardiovascular risk. Therefore, our objective was to evaluate the impact of a high-fructose diet on weight gain, biochemical and oxidative stress parameters, and liver histology and investigate fish oil’s potential protective role. Thirty male Wistar rats were divided into 3 groups: regular chow diet (CT), regular chow diet plus 20% fructose in drinking water (Fr), and a diet containing 10% fish oil plus 20% fructose in drinking water (FOFr). After 12 weeks, tissues of interest were collected for biochemical and histological analyses.

Results
Although fructose consumption did not lead to increased hepatic fat, it caused a significant increase in weight gain, white adipose tissue, and serum triglycerides in the Fr group, while fish oil promoted normalized serum triglycerides and even reduced adiposity in the FOFr group. Additionally, the inclusion of fish oil in the FOFr diet led to increased liver lipid peroxidation in the form of increased hepatic MDA.

Conclusions
It is concluded that fish oil can prevent important metabolic alterations caused by fructose consumption, but its dosage must be taken into account to prevent oxidative stress and potential liver damage.
The deleterious effects of chronic obstructive pulmonary disease and obstructive sleep apnea: pathophysiology and implications on treatment
Authors: Gharib Ahmed 
Published: September 2020

AbstractBackgroundChronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) are both common in the adult population. The coexistence and association of both COPD and OSA have been described as the overlap syndrome. The scope of the present review is to address the magnitude, pathophysiology, clinical presentations, and the deleterious consequences of the coexistence of COPD and OSA in the same patient as well as the current management and treatment options of this association.Main body of abstractEpidemiological studies showed a prevalence of the overlap syndrome of up to 1% of the adult population. However, various studies agreed that this association is due to the fact that both COPD and OSA are common rather than an interaction of pathophysiology between the two affections. Nevertheless, sleep may cause adverse effects on breathing and lung functions. While these effects can be neglected in otherwise healthy individuals, they can lead in contrast to disastrous clinical outcomes particularly in vulnerable patients with the overlap syndrome leading to increased risk of cardiovascular diseases, acute COPD exacerbations, increased rates of hospitalizations, and nocturnal deaths. Current guidelines recommend polysomnography (PSG) as the gold standard investigation to diagnose sleep disorders and overlap syndrome. Treatment may include pulmonary rehabilitation, supplemental oxygen therapy, and non-invasive ventilation. Currently, continuous positive airway pressure (CPAP) therapy is the treatment of choice for the overlap syndrome. CPAP effects include improved respiratory mechanics; sleep quality, exercise tolerance, and prolonged survival.ConclusionBoth COPD and OSA are common in the general population and present a significant risk of increased morbidity and mortality when they coexist in the same patient. Clinicians must carefully evaluate the clinical outcomes and the high risk of cardiovascular complications related to the overlap syndrome. Current data indicate that CPAP treatment leads to amelioration of the health-related quality of life and improve survival in patients with the overlap syndrome.
CDKN2C-Null Leiomyosarcoma: A Novel, Genomically Distinct Class of TP53/RB1–Wild-Type Tumor With Frequent CIC Genomic Alterations and 1p/19q-Codeletion
Authors: Williams Erik A. , Sharaf Radwa , Decker Brennan , Werth Adrienne J. , Toma Helen , Montesion Meagan , Sokol Ethan S. , Pavlick Dean C. , Shah Nikunj , Williams Kevin Jon , Venstrom Jeffrey M. , Alexander Brian M. , Ross Jeffrey S. , Albacker Lee A. , Lin Douglas I. , Ramkissoon Shakti H. , Elvin Julia A. 
Published: September 2020

PURPOSE Leiomyosarcoma (LMS) harbors frequent mutations in TP53 and RB1 but few actionable genomic alterations. Here, we searched for recurrent actionable genomic alterations in LMS that occur in the absence of common untreatable oncogenic drivers. METHODS Tissues from 276,645 unique advanced cancers, including 2,570 uterine and soft tissue LMS, were sequenced by hybrid-capture–based next-generation DNA and RNA sequencing/comprehensive genomic profiling of up to 406 genes. We characterized clinicopathologic features of relevant patient cases. RESULTS Overall, 77 LMS exhibited homozygous copy loss of CDKN2C at chromosome 1p32.3 (3.0% of LMS). Genomic alterations (GAs) in TP53, RB1, and ATRX were rare compared with the remainder of the LMS cohort (11.7% v 73.4%, 0% v 54.5%, 2.6% v 24.5%, respectively; all P < .0001). CDKN2C-null LMS patient cases were significantly enriched for GAs in CIC (40.3% v 1.4%) at 19q13.2, CDKN2A (46.8% v 7.0%), and RAD51B (16.9% v 1.7%; all P < .0001). Chromosome arm-level aneuploidy analysis of available LMS patient cases (n = 1,284) found that 81% (58 of 72) of CDKN2C-null LMS exhibited 1p/19q-codeletion, a significant enrichment compared with 5.1% in the remainder of the LMS cohort ( P < .0001). In total, 99% of CDKN2C-null LMS were in women; the median age was 61 years at surgery (range, 36-81 years). Fifty-five patient cases were uterine primary, four were nonuterine, and the remaining 18 were of uncertain primary site. Sixty percent of cases showed at least focal epithelioid variant histology. Most patients had advanced-stage disease, with 62% of confirmed uterine primary LMS at International Federation of Gynecology and Obstetrics stage IVB. We further validated our findings in two publicly available datasets: The Cancer Genome Atlas and the Project GENIE initiative. CONCLUSION CDKN2C-null LMS defines a genomically distinct tumor that may have prognostic and/or therapeutic clinical implications, including possible use of specific cyclin-dependent kinase inhibitors.
Cell and animal models of SARS-CoV-2 pathogenesis and immunity
Authors: Leist Sarah R. , Schäfer Alexandra , Martinez David R. 
Published: September 2020

ABSTRACT
The spread of the novel virus SARS coronavirus 2 (SARS-CoV-2) was explosive, with cases first identified in December 2019, and &gt;22 million people infected and &gt;775,000 deaths as of August 2020. SARS-CoV-2 can cause severe respiratory disease in humans leading to coronavirus disease 2019 (COVID-19). The development of effective clinical interventions, such as antivirals and vaccines that can limit or even prevent the burden and spread of SARS-CoV-2, is a global health priority. Testing of leading antivirals, monoclonal antibody therapies and vaccines against SARS-CoV-2 will require robust animal and cell models of viral pathogenesis. In this Special Article, we discuss the cell-based and animal models of SARS-CoV-2 infection and pathogenesis that have been described as of August 2020. We also outline the outstanding questions for which researchers can leverage animal and cell-based models to improve our understanding of SARS-CoV-2 pathogenesis and protective immunity. Taken together, the refinement of models of SARS-CoV-2 infection will be critical to guide the development of therapeutics and vaccines against SARS-CoV-2 to end the COVID-19 pandemic.
<p><strong>A new nasute-termite <em>Ceylonitermes nivedita </em>sp. nov. (Isoptera: Termitidae) from India along with first record of worker dimorphism </strong></p>
Authors: BASAK JAYATI , SENGUPTA RITUPARNA , KELOTH RAJMOHANA , BARAIK BALMOHAN 
Published: September 2020

A new nasute termite Ceylonitermes nivedita sp. nov. (Isoptera: Termitidae) is described from the tropical rainforests of Manipur, India. Both the soldier and worker castes of the species are described. The workers are strongly dimorphic and no such dimorphism is reported hitherto among the 3 known species of Ceylonitermes. A revised dichotomous key to identify all the 4 known species of the genus is also provided. The proposed new species is a minor pest of bamboo. Key words: Ceylonitermes, India, Nasutitermitinae, key
<p><strong>Two new species of Neotropical cicadas (Hemiptera: Cicadidae: Cicadettinae) from southeastern Brazil</strong></p>
Authors: SANBORN ALLEN F. 
Published: September 2020

Two new cicada species, Calyria uncinata sp. nov. (Parnisini Distant, 1905a) and Herrera chelappendicula sp. nov. (Carinetini Distant, 1905b) are described and illustrated from southeastern Brazil. Additional information is provided to distinguish these species from related Brazilian cicadas. Key words: Taxonomy, Calyria, Herrera, Neotropics, South America
Efficacy and Safety of Nadroparin Calcium-Warfarin Sequential Anticoagulation in Portal Vein Thrombosis in Cirrhotic Patients: A Randomized Controlled Trial
Authors: Zhou Ting , Sun Xin , Zhou Tao , Li Yueyue , Chen Xiaoning , Cheng Baoquan , Gao Yanjing 
Published: September 2020

INTRODUCTION:
Anticoagulation therapy in portal vein thrombosis (PVT) in patients with cirrhosis is still a matter of debate. Therefore, the aim of this work was to evaluate the efficacy and safety of nadroparin calcium-warfarin sequential (NWS) anticoagulation therapy in cirrhotic patients and to find an optimal anticoagulation strategy.

METHODS:
Consecutive cirrhotic patients with PVT who have not received anticoagulation therapy were randomly divided into the NWS therapy group (1-month nadroparin calcium by subcutaneous injection followed by 5-month warfarin by oral administration) and control group (no anticoagulation therapy). Overall recanalization rate of PVT and risks of bleeding were evaluated at the sixth month.

RESULTS:
Among 64 patients, complete or partial recanalization of PVT was observed in 20/32 NSW therapy group patients vs 11/32 control group patients (62.5% vs 34.4%, P = 0.024), with no statistically significant difference in bleeding rate. Child-Pugh score (P = 0.023), D-dimer < 2.00 μg/mL (P = 0.020), and NWS anticoagulation therapy (P = 0.004) were predictors associated with the recanalization. NWS anticoagulation therapy (P = 0.008) was an independent predicting factor of recanalization. In the NWS therapy group, the Child-Pugh score (P = 0.007) and albumin level (P = 0.004) were improved in the sixth month.

DISCUSSION:
NWS anticoagulation therapy was effective and safe in PVT patients with cirrhosis and could increase the level of albumin. NWS therapy is safe and easily accepted.
MEDIAÇÃO DOS MECANISMOS DE GOVERNANÇA NA RELAÇÃO ENTRE CAPACIDADE OPERACIONAL E CAPITAL INTELECTUAL NO DESEMPENHO INOVADOR DE EMPRESAS
Authors: Longo Luci , Pacheco Vicente , Guimarães Andre José Ribeiro 
Published: September 2020

O objetivo desta pesquisa consiste em analisar o efeito mediador de mecanismos de governança na relação entre capacidade operacional, tecnologia e capital intelectual para compreender o desempenho inovador de empresas de pequeno porte (EPP). Na fase de preparação e coleta dos dados, houve a participação do Serviço Apoio às Micro e Pequenas Empresas do Paraná (SEBRAE-PR), que auxiliou no processo de seleção das empresas, por meio da ferramenta de inteligência de dados para classificar aquelas com alto potencial para inovação. Gerar inovação tornou-se necessário para todos os segmentos de empresas, porém é igualmente importante entender suas fontes, como do capital intelectual e outras variáveis. Quanto aos aspectos metodológicos, adotou a abordagem quantitativa, por meio do Método de Equações Estruturais (PLS). O modelo possui quatro variáveis preditoras para compreender os efeitos na variável dependente Desempenho Inovador. Dentre os resultados encontrados, a pesquisa afere que mecanismos de governança está mediando capital intelectual em 32,2% na relação final para o desempenho inovador. Esta mediação é percebida em três dos quatro fatores. O modelo proposto foi capaz de explicar 66,4% do “Desempenho Inovador” destas empresas. Uma das contribuições da pesquisa é a comprovação empírica de que o capital intelectual pode ser promovido a partir da capacidade absortiva, em especial supervisão, que impacta no desempenho das empresas analisadas. Os resultados estão em consonâncias com a literatura estudada. Para futuras pesquisas considera-se importante a ampliação do número de empresas para outras regiões brasileiras, devido à importância das EPP no cenário nacional e mundial.
FINANCIAL REPORTING COMO INSTRUMENTO IDEOLÓGICO PARA FINS HEGEMÔNICOS: EVIDÊNCIAS DO BANCO DO BRASIL (1853–1902)
Authors: Sayed Samir 
Published: September 2020

O objetivo central do nosso estudo é evidenciar e entender como o poder dominante brasileiro se apoderou do financial reporting e da contabilidade em si como instrumento ideológico e consequentemente de controle hegemônico, através da criação de uma realidade que satisfaça seus interesses materiais. A unidade de estudo é o Banco do Brasil entre 1853 e 1902, fase de muitas mudanças sociais, econômicas e políticas no país. Baseando-se na abordagem crítica, em um estudo de caráter histórico através de pesquisa documental primária, utilizamos a plataforma teórica do marxista italiano Antonio Gramsci (1891-1937) em suas definições de hegemonia e ideologia, sobretudo. Os documentos foram analisados segundo questões contábeis específicas, sobretudo o cálculo do lucro e a distribuição de dividendos, além do discurso empregado. As conclusões apontam que o Banco do Brasil ao longo do período áureo da produção cafeeira nacional foi utilizado pelo poder dominante, apoderado do Estado, para a transferência de recursos para a burguesia, contribuindo de maneira importante para a desigualdade econômica e social em nosso país. Especificamente através da interface entre sociedade civil e sociedade política no seio do Estado Brasileiro durante o período estudado. Em segundo lugar, analisamos o vínculo orgânico entre a estrutura e a superestrutura no Brasil e os efeitos para os beneficiados. Argumentamos, pois, que o financial reporting e a contabilidade são instrumentos de disseminação e controle ideológico, mas ao conterem essas características, evidenciam adicionalmente as contradições do sistema capitalista-burguês.
Potencial contribuição da agricultura familiar para uma alimentação escolar saudável no estado de Santa Catarina no período de 2015 a 2017
Authors: Vieira Gisele Assumpção , Teo Carla Rosane Paz Arruda , Taglietti Roberta Lamonatto 
Published: September 2020

O objetivo do estudo foi analisar a contribuição dos alimentos presentes nos editais de chamada pública dos municípios catarinenses para aquisição da agricultura familiar para a alimentação escolar quanto à oferta de marcadores alimentares saudáveis, no período de 2015 a 2017. Foi realizada uma pesquisa documental de abordagem quantitativa e caráter analítico. Com base nos marcadores de alimentação saudável presentes nas chamadas púbicas analisadas, foi identificado, que a quantidade média per capita de frutas e hortaliças contempla a recomendação estipulada pelo Fundo Nacional de Desenvolvimento da Educação – FNDE (200g/aluno/semana) sendo atendida tanto pela oferta de frutas (r=0,912; p<0,01) como pela oferta de hortaliças (r=859; p<0,01), porém a quantidade média per capita de feijões foi ínfima. Foram observadas 48 variedades no grupo das hortaliças, 35 variedades no grupo das frutas e nove variedades no grupo dos feijões, porém, a variedade do grupo das frutas e feijões se apresentou baixa se comparada à do grupo das hortaliças. Os achados permitem concluir, a partir dos alimentos presentes nas chamadas públicas, que a agricultura familiar tem relevante potencial para a oferta de uma alimentação escolar saudável no estado catarinense. Contudo, para que esse potencial se realize, é importante que os editais sejam mais bem elaborados, de forma a considerar a produção e o desenvolvimento da agricultura familiar local, com foco em alimentos saudáveis.
Notes from the Editors, September 2020
Authors: The Editors - 
Published: September 2020

buy this issue
Climate change is just one part of a larger planetary emergency related to the crossing of planetary boundaries due to the system of capital accumulation. New diseases that can be transferred from animals to humans such as COVID-19 are another part. Knowledge of the overall planetary emergency in which the world is immersed, and its relation to capitalism, is thus crucial to our time.
Associations Between Heart Rate Variability–Derived Indexes and Training Load: Repeated Measures Correlation Approach Contribution
Authors: Davletyarova Ksenya , Vacher Philippe , Nicolas Michel , Kapilevich Leonid V. , Mourot Laurent 
Published: September 2020

Abstract
Davletyarova, K, Vacher, P, Nicolas, M, Kapilevich, LV, and Mourot, L. Associations between heart rate variability–derived indexes and training load: repeated measures correlation approach contribution. J Strength Cond Res 36(7): 2005–2010, 2022—This study aimed to evaluate whether similar associations between indexes derived from heart rate variability (HRV) analyses and training load (TL) could be obtained by using the commonly used Pearson correlation technique and the repeated measures correlation (rmcorr). Fourteen well-trained swimmers (18.5 ± 1.6 years) participated. The training period lasted 4 weeks with a gradual increase in TL. Daily external TL (exTL) and internal TL (inTL) were summed to obtain a weekly TL, and HRV analyses were performed every Saturday morning. During the 4-week period, exTL and inTL increased (p < 0.05) together with a decrease (p < 0.05) in heart rate and an increase (p < 0.05) of cardiac parasympathetic indexes. No significant correlation was found using Pearson correlation while significant associations were found using rmcorr; considering exTL, positive (mean R-R interval [MeanRR], root mean square of differences between successive RR interval [RMSSD], low frequency [LF], high frequency [HF], instantaneous beat-to-beat variability [SD1], continuous beat-to-beat variability [SD2], SD1/SD2; r from 0.59 to 0.46, p value from <0.001 to 0.002) and negative (mean heart rate [meanHR]; r = −0.55, p < 0.001) associations were found. Considering inTL, positive (MeanRR, RMSSD, LF, HF, HFnu, SD1, SD2, SD1/SD2; r from 0.56 to 0.34, p-value from <0.001 to 0.025) and negative (meanHR, LFnu, LF/HF; r from −0.49 to −0.34, p value from 0.001 to 0.025) associations were found. The rmcorr statistical method was able to show associations between parasympathetic indexes and TL contrary to Pearson correlation analysis. Because rmcorr is specifically designed to investigate within-individual association for paired measures assessed on 2 or more occasions for multiple individuals, it should constitute a tool for future training monitoring researches based on a repeated-measures protocol.
Modern Learning Strategies in Higher Education: Team-Based Learning
Authors: Aleksandravičiūtė Birutė , Liekis Kęstutis 
Published: September 2020

Team-based learning is a student-orientated active learning strategy created by Lary Michaelsen in 1979. Team-based learning is widely used not only in the United States of America, but all around the world: in Asian, European, and Middle Eastern universities and colleges. It is extremely popular in biomedicine as well as in social sciences. It is, unfortunately, rare in Lithuanian higher education. There is a large network of team-based learning strategy consultants in Singapore, Japan, Australia, the Netherlands, the United Kingdom, Uruguay, and North America.Research aim: to introduce the team-based learning strategy.Research questions: what is team-based learning strategy? What are the main reasons of the prevalence of team-based learning strategies? How is the team-based learning strategy adopted to the learning subject?Research object: Team-based learning strategy.Research method: literature analysis.The popularity of team-based learning is determined by its effectiveness: it motivates students, ensures their involvement, develops critical thinking, problem-solving, interpersonal leadership, and conflict management and similar skills. Team-based learning ensures the satisfaction of students with the learning process.There are four essential elements of the team-based learning strategy: teams must be properly formed and managed; students must be motivated to attend class and must come prepared; students must learn to use course concepts to solve problems; students must be truly accountable in case the lecturer decides to implement team based learning into their subject.
Brain-derived neurotrophic factor gene polymorphism in post-ST-elevation myocardial infarction patients undergoing primary percutaneous intervention
Authors: Petyunina Olga V. , Kopytsya Mykola P. , Berezin Alexander E. 
Published: September 2020

Introduction: The goal of this study was to elucidate a link of brain-derived factor (BDNF) Val66Met gene with combined 6-month clinical end points in post-myocardial infarction patients.
Methods: 256 post-myocardial infarction patients who underwent primary coronary intervention were enrolled in the study. Variants of Val66Met gene BDNF were identified by real-time chain reaction at baseline.
Results: The combined clinical end points (major cardiovascular events and hospitalization) were determined in 61 (23.8%) post-STEMI patients; consequently, 195 (76.2%) patients did not meet the events. linear regression revealed that predictors for combined clinical end points were peak TnI levels, NT-proBNP, SYNTAX score, TIMI score, obesity, left ventricular ejection fraction, and 66ValMet+66MetMet in BDNF gene. The cumulative clinical outcomes (major adverse cardiac events and admission) were determined in 61 (23.8%) patients. Kaplan-Meier curves demonstrated that 66ValVal of BDNF gene was significantly associated with the low number of combined end points.
Conclusion: The Val66Met in BDNF gene independently predicted 6-month combined clinical end points in post-myocardial infarction patients.