bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coseismic changes in groundwater level during the 2018 Hokkaido Eastern Iburi earthquake
Authors: Shibata Tomo , Takahashi Ryo , Takahashi Hiroaki , Kagoshima Takanori , Takahata Naoto , Sano Yuji , Pinti Daniele L. 
Published: February 2020

AbstractSix wells were continuously monitored in Hokkaido, northern Japan, to relate groundwater level changes to regional seismic activity. Groundwater level changes following the 2018 Hokkaido Eastern Iburi earthquake were detected in three of the six wells, even though they are located hundreds of kilometers from the epicenter. The groundwater level changes are qualitatively consistent with the volumetric strain induced by the earthquake. We analyzed groundwater level responses to the M2tidal constituent before and after the earthquake, but related changes in amplitude and phase shifts remained within the usual variation. Observed coseismic change was explained by the response to the M2tidal constituent component and the calculated volumetric strain for one of the wells, where groundwater level decreased. The observed change in the other two was found to be much greater than the corresponding estimates of the volumetric strain.
Anesthetic management of a child with catecholaminergic polymorphic ventricular tachycardia undergoing insertion of implantable cardioverter defibrillator : a case report
Authors: Omiya Keisuke , Mitsui Kazuha , Matsukawa Takashi 
Published: February 2020

AbstractBackgroundCatecholaminergic polymorphic ventricular tachycardia (CPVT) is a fatal cardiac ion channelopathy that causes sudden unexpected death in the young.Case presentationThe patient was a 3-year-old girl with CPVT. Insertion of an implantable cardioverter defibrillator (ICD) using epicardial pacing was scheduled. After premedication of rectal midazolam was given, general anesthesia was induced with midazolam, fentanyl, and rocuronium, and maintained with midazolam, fentanyl, remifentanil, and rocuronium. The operation was performed without any complications. Dexmedetomidine and fentanyl were continuously infused after the operation until she was extubated in the morning of postoperative day 1. Fatal arrhythmia due to perioperative stress did not occur.ConclusionsWe report the anesthetic management of a child with CPVT who underwent insertion of an ICD. CPVT-induced fatal arrhythmia did not occur perioperatively by carefully avoiding perioperative stress with premedication and post-operative sedation.
Ventral sculpting decompression: a novel bone scalpel-based technique in thoracic ventral stenosis/kyphosis with myelopathy
Authors: Krishnan Ajay , Patil Sameer , Reddy Chaitanya , Mayi Shivanand , Degulmadi Devanand , Rai Ravi Ranjan , Dave Bharat R. 
Published: February 2020

Abstract
Background
Thoracic kyphosis is not so uncommon, which presents with devastating myelopathy. In the past, the surgical treatment for it had been somewhat controversial. Traditionally, it had been addressed by open decompression and stabilization with significant dissection and disruption of normal tissues and complications.

Main body
Recently, correction techniques have evolved as the standard of care. A substantial body of evidence now supports the benefits of correction but can be questioned in view of the fact that upper dorsal kyphosis is never a cosmetic concern in our part of the world. New technique has reduced complications, but it is not solely due to the technique but due to accessory gadgets like O-arm, navigation, and IONM making it safer. We describe a method of 360° decompression alone with the use of an Ultrasonic Bone Scalpel (UBS) that preserves maximum bony stability and achieves an optimum bone sculpting that negates the need for correction.

Conclusion
This technique of ventral sculpting decompression in the thoracic spine may be more utilized in the future to be applied for more wider indications.
Mineral bone disorder and osteoporosis in hemodialysis patients
Authors: Slouma Maroua , Sahli Hela , Bahlous Afef , Laadhar Lilia , Smaoui Wided , Rekik Sonia , Gharsallah Imen , Sallami Meriem , Moussa Fatma Ben , Elleuch Mohamed , Cheour Elhem 
Published: February 2020

Abstract
Background
Bone disease is common in patients undergoing hemodialysis. It is the result of bone turnover abnormalities and the decrease of bone mineral density (BMD). We aimed to determine the usefulness of serum bone turnover markers and BMD measurement by dual-energy x-ray absorptiometry (DXA) in hemodialysis patients.

Methods
We conducted a cross-sectional study including 90 hemodialysis for more than 12 months. Bone mineral density was assessed by DXA. Peripheral blood samples were obtained from each patient before dialysis in a fasting state within a week of the DXA. Biochemical variables of calcium and phosphate were measured. One bone formation marker (bone-specific alkaline phosphatase (bAP), one bone resorption marker (carboxy-terminal telopeptides of type 1 collagen (CTX)) were measured. Total alkaline phosphatase (TAP), intact parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) which is a bone-derived hormone were also measured.

Results
CTX values were 6.25 times higher than the normal limit of the assay. Bone alkaline phosphatase levels were less than 10 ng/mL in 28.8% of cases. 23% of patients have osteoporosis and 45% have osteopenia. Femoral BMD had negative correlations with age and PTH levels. FGF23 levels were significantly increased in patients with osteoporosis affecting the lumbar. The levels of bAP and CTX showed a positive correlation. Both circulating bAP and CTX levels showed also positive correlations with PTH levels. Fractures, observed in 12.2% of cases, were associated with low PTH values and the existence of osteoporosis.

Conclusions
Our study showed that osteoporosis and fracture are common in dialysis patients. The reduced BMD was associated with advanced age and elevated levels of PTH. Markers of bone turnover and FGF23 may play a role in the diagnosis of bone disease in hemodialysis patients. DXA measurement is necessary for the monitoring for bone loss.
The association of gr/gr deletion in the Y chromosome and impaired spermatogenesis in Bulgarian males: a pilot study
Authors: Levkova Mariya , Chervenkov Trifon , Angelova Lyudmila 
Published: February 2020

Abstract
Background
The microdeletions of the Y chromosome are associated with a decreased number of sperm cells in the ejaculate and male infertility. One such deletion is the gr/gr, which leads to reduction of the alleles in the DAZ gene. In order to evaluate its role, 30 patients with sperm count below 5 × 106/mL and 30 normal fertile men were genotyped for microdeletions in Azoospermia Factor (AZF) region, including gr/gr deletion.

Results
Twenty-one men (70.00%) from the males with impaired fertility had a normal genotype, seven men (23.33%) were carriers of a gr/gr deletion, and two men (6.67%) demonstrated a deletion of the AZFc region. From the control group, there were 22 men (73.33%) with no deletion, seven (23.33%) carried a gr/gr deletion, and one man (3.33%) carried a possible deletion in the b1-b4 region of the Y chromosome. The gr/gr deletion of the Y chromosome showed a statistically nonsignificant difference (p = 0.94, alpha < 0.05) with the control group (chi-square, degrees of freedom 0.006).

Conclusion
The results from the research show no association between this deletion and male infertility in the studied population. Despite the small sample size, the high frequency of the gr/gr deletion, found in the control group, suggests that this variant may not be associated with impaired spermatogenesis.
Reactive oxygen species or reactive sulfur species: why we should consider the latter
Authors: Olson Kenneth R. 
Published: February 2020

ABSTRACT
The biological effects of oxidants, especially reactive oxygen species (ROS), include signaling functions (oxidative eustress), initiation of measures to reduce elevated ROS (oxidative stress), and a cascade of pathophysiological events that accompany excessive ROS (oxidative distress). Although these effects have long been studied in animal models with perturbed ROS, their actions under physiological conditions are less clear. I propose that some of the apparent uncertainty may be due to confusion of ROS with endogenously generated reactive sulfur species (RSS). ROS and RSS are chemically similar, but RSS are more reactive and versatile, and can be stored and reused. Both ROS and RSS signal via oxidation reactions with protein cysteine sulfur and they produce identical effector responses, but RSS appear to be more effective. RSS in the form of persulfidated cysteines (Cys-S-S) are produced endogenously and co-translationally introduced into proteins, and there is increasing evidence that many cellular proteins are persulfidated. A number of practical factors have contributed to confusion between ROS and RSS, and these are discussed herein. Furthermore, essentially all endogenous antioxidant enzymes appeared shortly after life began, some 3.8 billion years ago, when RSS metabolism dominated evolution. This was long before the rise in ROS, 600 million years ago, and I propose that these same enzymes, with only minor modifications, still effectively metabolize RSS in extant organisms. I am not suggesting that all ROS are RSS; however, I believe that the relative importance of ROS and RSS in biological systems needs further consideration.
Tumor radiomic features complement clinico-radiological factors in predicting long-term local control and laryngectomy free survival in locally advanced laryngo-pharyngeal cancers
Authors: Agarwal Jai Prakash , Sinha Shwetabh , Goda Jayant Sastri , Joshi Kishor , Mhatre Ritesh , Kannan Sadhana , Laskar Sarbani Ghosh , Gupta Tejpal , Murthy Vedang , Budrukkar Ashwini , Mummudi Naveen , Ganeshan Balaji 
Published: February 2020

Objective:
To study if pre-treatment CT texture features in locally advanced squamous cell carcinoma of laryngo-pharynx can predict long-term local control and laryngectomy free survival (LFS).

Methods:
Image texture features of 60 patients treated with chemoradiation (CTRT) within an ethically approved study were studied on contrast-enhanced images using a texture analysis research software (TexRad, UK). A filtration-histogram technique was used where the filtration step extracted and enhanced features of different sizes and intensity variations corresponding to a particular spatial scale filter (SSF): SSF = 0 (without filtration), SSF = 2 mm (fine texture), SSF = 3–5 mm (medium texture) and SSF = 6 mm (coarse texture). Quantification by statistical and histogram technique comprised mean intensity, standard-deviation, entropy, mean positive pixels, skewness and kurtosis. The ability of texture analysis to predict LFS or local control was determined using Kaplan–Meier analysis and multivariate cox model.

Results:
Median follow-up of patients was 24 months (95% CI:20–28). 39 (65%) patients were locally controlled at last follow-up. 10 (16%) had undergone salvage laryngectomy after CTRT. For both local control & LFS, threshold optimal cut-off values of texture features were analyzed. Medium filtered-texture feature that were associated with poorer laryngectomy free survival were entropy ≥4.54, (p = 0.006), kurtosis ≥4.18; p = 0.019, skewness ≤−0.59, p = 0.001, and standard deviation ≥43.18; p = 0.009). Inferior local control was associated with medium filtered features entropy ≥4.54; p 0.01 and skewness ≤ – 0.12; p = 0.02. Using fine filters, entropy ≥4.29 and kurtosis ≥−0.27 were also associated with inferior local control (p = 0.01 for both parameters). Multivariate analysis showed medium filter entropy as an independent predictor for LFS and local control (p &lt; 0.001 & p = 0.001).

Conclusion:
Medium texture entropy is a predictor for inferior local control and laryngectomy free survival in locally advanced laryngo-pharyngeal cancer and this can complement clinico-radiological factors in predicting prognosticating these tumors.

Advances in knowledge:
Texture features play an important role as a surrogate imaging biomarker for predicting local control and laryngectomy free survival in locally advanced laryngo-pharyngeal tumors treated with definitive chemoradiation.
Precise determination of the optical properties of turbid media using an optimized integrating sphere and advanced Monte Carlo simulations. Part 2: experiments
Authors: Bergmann Florian , Foschum Florian , Zuber Ralf , Kienle Alwin 
Published: February 2020

Based on theoretical investigations of the light propagation within an integrating sphere, we developed an accurate method to determine the optical properties of scattering media using an integrating sphere-based setup. The method takes into account the exact sphere geometry as well as the different angular distributions of the reflected and transmitted light from the sample and the calibration standard. We tested our novelties successfully in theory with Monte Carlo simulations and in practice using a 3D printed and professionally coated integrating sphere. As a result, we were able to determine precisely the effective scattering coefficient,

μ

s

′

, and the absorption coefficient,

μ

a

, between 400 nm and 1500 nm in a range of

μ

a

=
1

e
−

3

m
m

−
1

to

10

m
m

−
1

and

μ

s

′

=
0.2

m
m

−
1

to

100

m
m

−
1

. Usually, the accuracy was around 1% for

μ

s

′

and around 3% for

μ

a

for turbid phantom media with an optical thickness

τ
=

μ

s

′

d
>
1

and a transmittance signal

>

0

.

1

%

.
On the measurement of the nonlinear optical response of graphene dispersions using fs lasers
Authors: Karampitsos Nikolaos , Kyrginas Dimitrios , Couris Stelios 
Published: February 2020

In this work, the nonlinear optical (NLO) response of some graphene dispersions is investigated under low (i.e., 10 Hz) and high (i.e., 80 MHz) repetition rate femtosecond (fs) laser excitation conditions, using

Z

-scan, optical Kerr effect (OKE), and a combination of

Z

-scan and thermal lensing techniques. It is shown, that the NLO response of graphene dispersions is negligible under low repetition rate fs laser excitation, while it becomes very large under high repetition rate laser excitation. In the latter case, it is shown that the observed very large NLO response arises entirely from thermal cumulative effects.
Treatment of Idiosyncratic Drug-Induced Liver Injury Using Steroids
Authors: Sundaram Suneha , Vuppalanchi Raj , Saxena Romil , Chalasani Naga 
Published: February 2020

ABSTRACT
Idiosyncratic drug-induced liver injury (DILI), when severe, can be associated with significant morbidity and mortality. Currently, there are no specific therapies for DILI, apart from corticosteroids for drug-induced autoimmune hepatitis caused by drugs such as nitrofurantoin or minocycline. We present 2 cases of DILI that improved with corticosteroid therapy despite the lack of autoimmune features by serology or histology. The current observations make a strong case for formally testing corticosteroids in a controlled trial in patients with suspected DILI.
Acute Liver Injury due to Severe Epstein-Barr Virus Infection
Authors: Shah Jamil , Lingiah Vivek , Pyrsopoulos Nikolaos , Galan Mark 
Published: February 2020

ABSTRACT
Epstein-Barr virus (EBV) is a widely dispersed herpesvirus, transferred through close personal contact between susceptible individuals and asymptomatic shedders of the virus. The liver is often affected, and involvement is usually subclinical and self-limited. However, immunocompromised patients and, more rarely, immunocompetent individuals can develop a severe and potentially fatal acute liver injury. To differentiate EBV hepatitis from other conditions, such as autoimmune hepatitis, lymphoproliferative disorders, and drug-induced liver injury, correlation with clinical history, laboratory findings, and histopathologic features is crucial. We report a unique case of a man who developed acute liver injury from a severe EBV infection.
Congenital high airway obstruction syndrome complicated with foregut malformation and high airway fistula to the alimentary tract – a case series with four distinct types
Authors: Kanamori Yutaka , Tahara Kazunori , Ohno Michinobu , Tomonaga Kotaro , Yamada Yohei , Hishiki Tomoro , Fujino Akihiro , Miyazaki Osamu , Nosaka Shunsuke , Morimoto Noriko , Sugibayashi Rika , Ozawa Katsusuke , Wada Seiji , Sago Haruhiko , Tsukamoto Keiko , Isayama Tetsuya , Ito Yushi 
Published: February 2020

AbstractBackgroundCongenital high airway obstruction syndrome (CHAOS) is a rare disease and recently has been noticed to show typical prenatal images, such as hyperinflated lungs and flattened or inverted diaphragms. However, in some cases correct diagnosis may be difficult and in such cases the mortality rate increases.Case presentationWe report four cases of CHAOS complicated with a high airway fistula to the alimentary tract and foregut malformation. The patients did not show the typical features of CHAOS in the fetus. This may be attributed to the high airway fistula acting as a decompression route for the accumulated lung fluids to the alimentary tract.ConclusionThe combination of CHAOS, foregut malformation and a high airway fistula is very rare and classified into four distinct types: (1) CHAOS with a high airway fistula but not with a foregut malformation; (2) CHAOS with esophageal atresia and tracheoesophageal fistula; (3) CHAOS with a high airway fistula and duodenal atresia; and (4) CHAOS with esophageal atresia, tracheoesophageal fistula and duodenal atresia. It may be useful for treating physicians to be aware of these four distinct types and the typical characteristics of each type.
Rethinking the teaching of Latin in the inclusive school
Authors: Iovino Rossella 
Published: February 2020

Abstract
This paper aims at renewing the teaching of Latin applying the advances of the contemporary comparative linguistic research to the production and experimentation of materials for the teaching of (classical) languages. In addition, it addresses a particular aspect to which the Italian school is currently more and more sensitive, namely the inclusion of students with dyslexia (Italian law 170/2010). The method encourages students to formulate expectations on the contents of the Latin texts they read, by brainstorming activities, spotting keywords, and proposing collaborative hypotheses to the peer group. Furthermore, it proposes an inductive approach to the morphological analysis of the texts. Finally, it is very important to recognize the positive role of the cross-linguistic comparative approach to the texts, mostly (but not only) based on the reflection on the thematic structure of the verbs which is universal and only varies in its syntactic realization; on the recognition of phrases; on the graphic representation (first guided, then independent) of the syntactic structure of phrases and sentences.
Pain and social cognition: does pain lead to more stereotyped judgments based on ethnicity and age?
Authors: Gunnarsson Helena , Agerström Jens 
Published: February 2020

Abstract

Background and aims
Previous research on pain and cognition has largely focused on non-social cognitive outcomes (e.g. attention, problem solving). This study examines the relationship between pain and stereotyping, which constitutes a fundamental dimension of social cognition. Drawing on dual process theories of cognition, it was hypothesized that higher levels of pain would increase stereotyped judgments based on ethnicity and age. The hypothesis was tested in conjunction with experimentally induced pain (Study 1) and clinical pain (Study 2).

Methods
In Study 1, experimental pain was induced with the cold pressor method on a between-subjects basis. Participants (n = 151) completed a judgment task that assessed to what extent they relied on stereotypes (ethnic and age) when estimating other people’s cognitive performance. In Study 2, 109 participants with clinical, musculoskeletal pain completed the same stereotype judgment task. Correlations between stereotyped judgments and various pain qualities (intensity, interference with daily activities, duration, and persistence) were performed.

Results
In Study 1, pain induced participants did not form significantly more stereotyped judgments compared to pain-free participants. However, higher reported pain intensity was associated with more ethnically stereotyped judgments. In Study 2, there were no significant correlations between different aspects of clinical pain and stereotyped judgments.

Conclusions
The results provide weak support for the hypothesis that pain increases stereotyped judgments. This was the case for both experimentally induced pain and clinical pain. The present study is the first to investigate the link between pain and stereotyping, suggesting that stereotypical judgments may be a social cognitive outcome that is relatively unaffected by pain.

Implications
The results have practical implications for the clinic, for example, where chronic pain patients may not have greater difficulties interacting with health care professionals that are members of a stereotyped social group (e.g. ethnic).
Application of grey relational analysis and artificial neural networks on currency exchange-traded notes (ETNs)
Authors: Chen Jo-Hui , Diaz John Francis T. 
Published: February 2020

Abstract
This study determines which index has the strongest influence on the exchange-trade note (ETN) returns using the grey relational analysis. Results show that the volatility index is the strongest, followed by the S&P 500 stock index, the US dollar index, the CRB index, the Trade index, and the Brent crude oil index. However, the US dollar index has the most significant effect of using the index values of currency ETNs, followed by the S&P 500 stock index, volatility index, Brent crude oil index, the CRB index, and Trade index. This study applies four types of the artificial neural network model, namely, back-propagation neural network (BPN), recurrent neural network (RNN), time-delay recurrent neural network (TDRNN), and radial basis function neural network (RBFNN) to capture the nonlinear tendencies of ETNs for better forecasting accuracy. The paper finds that the RNN and RBFNN models have stronger predictive power among the models, and provides the highest forecasting accuracy for the majority of the currency ETNs. However, the RNN model consistently shows that the low grey relational grades (GRG) variables have the strongest influence on the ETN returns, compared with combining all and high GRG variables. These findings suggest that fund managers and traders can potentially rely on both RNN and RBFNN models, particularly the former, in their applications in financial time-series modeling.
Consideraciones respecto del derecho humano a la igualdad jurídica en el título séptimo de la Ley Federal Del Trabajo
Authors: De la Rosa Escalante Adrián , Serrano Castro Rodrigo 
Published: February 2020

Este trabajo es un análisis de la igualdad jurídica contenida en el texto de la Ley Federal del Trabajo en vigor, que abre con un atisbo breve de su evolución. El estudio de la igualdad jurídica se funda en su naturaleza de derecho humano y por ello se conceptualiza en principios, normas y garantías, razón por la cual su análisis se visualiza desde la perspectiva de la Constitución mexicana y desde la convencionalidad como bloque de constitucionalidad; seguidamente se hace referencia a la igualdad jurídica desde su dimensión sustantiva; a) Igualdad formal o en el texto de la ley, b) Igualdad ante la ley, con sus efectos directos, indirectos y remotos con los que se hace visible actualmente; posteriormente se aborda el concepto más aceptado de discriminación como prohibición y se identifica en el análisis en sus formas de a) restricción, b) discriminación directa y c) discriminación estructural. Para el desenlace se analizan como sustento jurídico los criterios de objetividad y razonabilidad, para finalizar con la conclusión.