bluuebunny/crossref_metadata_2025_split huggingface dataset:
Durable Thin‐Film DLC on Wafer Surfaces of Gravure Cylinders for Roll‐to‐Roll Printing of 1‐Bit Electrodes and Microtext in Flexible Electronics and Graphic Security
Authors: Seetharamiahsrinivasaraju Chandramohan , Shetty Ronit , Saxena Shivi , Sharma Priyanka , Cohen Donald , Springstead James , Oldenzijl Rudie 
Published: December 2024

AbstractDiamond‐Like Carbon (DLC), a thin‐film material, is emerging as a promising alternative for durable surfaces due to its eco‐friendly application process. This study evaluated the use of thin‐film DLC on the wafer surface of gravure cylinders for roll‐to‐roll printing of fine‐line electrodes and microtext patterns, specifically for applications in flexible electronics and graphics security. Results suggested that using thin film DLC on the wafer surface allows reliable reproduction of isometric grids and line structures with widths of 15, 20, and 30 µm, as well as solid electrodes. The uniform conformity of thin‐film DLC on the wafer surface, featuring an engraved micron‐size cell structure, demonstrates superior ink transfer onto flexible PET (polyethylene terephthalate) substrates. This results in increased electrode line width and reduced electrical resistance compared to chrome. Statistical analysis confirmed the reliability and repeatability of the findings. Visual analysis of lines and microtext also demonstrated the reliable print‐reproducing capabilities of DLC‐coated surfaces. Overall, these results suggest that thin‐film DLC is a promising alternative for use as a protective layer on gravure wafer surfaces. It has the potential to produce high‐quality, high‐volume electronics, such as sensors, antennas, and batteries, for applications in the Internet of Things (IoT) and other sustainable technologies.
Efficiency Boost in Through Space Charge Transfer Emitters: Insights from Spiro Lateral Rocking Confinement
Authors: Liu Rui‐Hong , Li Meng‐Tian , Yang Yue‐Jian , Ge Shi‐Jie , Qu Zhi‐Hao , Feng Zi‐Qi , Wang Yu , Yu Zhe‐Hong , Zhou Dong‐Ying , Zhong Cheng , Liao Liang‐Sheng , Jiang Zuo‐Quan 
Published: December 2024

AbstractIntramolecular through‐space charge‐transfer (TSCT) excited states have emerged as promising candidates for thermally activated delayed fluorescence (TADF) emitters. This study addresses the challenges in tuning excited state dynamics through conformational engineering, which significantly impacts exciton utilization. An effective strategy is presented to enhance the performance of TSCT‐TADF molecules by restricting the lateral rocking of the spiro unit via immobilizing groups, which indirectly adjusts the conformations of the donor and acceptor subunits. This approach is successfully illustrated with two TSCT‐TADF emitters, 8PhDM‐B and 8PyDM‐B, featuring sterical aryl phenyl and pyridine substitutions at the C8 site of a rigid spiro‐fluorene bridge. Organic light‐emitting diodes (OLEDs) utilizing these emitters demonstrated impressive maximum external quantum efficiencies of 33.1% and 31.0%, respectively. The findings underscore the importance of the rocking confined strategy in refining excited state dynamics, thereby providing valuable insights for the design of highly efficient OLED emitters.
PRMT1 Promotes the Self‐renewal of Leukemia Stem Cells by Regulating Protein Synthesis
Authors: Zhou Min , Huang Yi , Xu Ping , Li Shuyi , Duan Chen , Lin Xiaoying , Bao Shilai , Zou Waiyi , Pan Jingxuan , Liu Chang , Jin Yanli 
Published: December 2024

AbstractThe application of tyrosine kinase inhibitors (TKIs) has revolutionized the management of chronic myeloid leukemia (CML). However, disease relapse and progression particularly due to persistent leukemia stem cells (LSCs) remain a big challenge in the clinic. Therefore, validation of the therapeutic vulnerability in LSCs is urgently needed. This study verifies the critical role of protein arginine methyltransferase 1 (PRMT1) in the maintenance of CML LSCs. It is found that PRMT1 promotes the survival and serially plating abilities of human primary CML LSCs. Genetic deletion of Prmt1 significantly delays the leukemogenesis and impairs the self‐renewal of LSCs in BCR‐ABL–driven CML mice. PRMT1 regulates LSCs and leukemia development depending on its methyltransferase activity. Pharmacological inhibition of PRMT1 activity by MS023 remarkably eliminates LSCs and prolongs the survival of CML mice. Mechanistical studies reveal that PRMT1 promotes transcriptional activation of ribosomal protein L29 (RPL29) via catalyzing asymmetric dimethylation of histone H4R3 (H4R3me2a) at its gene promoter region. PRMT1 augments the global protein synthesis via RPL29 in CML LSCs. Taken together, the findings provide new evidence that histone arginine methylation modification regulates protein synthesis in LSCs and highlight PRMT1 as a valuable druggable target for patients with CML.
Potential guidelines for cataract surgery and rehabilitation in visually impaired patients: Literature analysis
Authors: Limoli Paolo Giuseppe , Limoli Celeste , Nebbioso Marcella 
Published: December 2024

AbstractCataracts can reduce the quality of vision in visually impaired patients who already have a visual impairment. The most common causes of low vision include age‐related macular degeneration (AMD), high myopia (HM), diabetic retinopathy (DR), glaucoma (GL), and inherited degenerative ocular diseases. The surgery aims to improve their independence, quality of life, and ability to engage in daily, social, and work activities. Phacoemulsification and intraocular lens (IOL) implantation, combined with visual rehabilitation, can improve visual acuity of visually impaired patients. Therefore, comprehensive guidelines for cataract surgery in patients with low vision would be beneficial to ensure optimal surgical outcomes by improving surgical planning, execution, and postoperative care, along with a well‐coordinated rehabilitation process. In cases of reduced metabolism, such as low vision, oxidative stress can be aggravated by light exposure and surgical interventions. Thus, maintaining redox balance is crucial for stabilizing retinal conditions. Patients with visual impairments rely on retinal regions with the greatest residual function, and cataract surgery aims to enhance focus on these areas, improving reading quality and reducing scotoma perception. Thorough informed consent is crucial, ensuring that patients are fully aware of the potential risks, benefits, and limitations of surgery. Close postoperative follow‐up in the first 6 months is crucial to detect and manage any complications promptly, such as reactivation of maculopathy. The aim of this work is to establish potential guidelines for optimal rehabilitation outcomes through careful literature analysis.
Screening of pure silica zeolites with high ethane/ethylene separation selectivity by simulations and experiments
Authors: Zhang Peixin , Hu Jianbo , Zhou Dengzhuo , Lu Xiaofei , Yang Lifeng , Chen Liyuan , Suo Xian , Cui Xili , Xing Huabin 
Published: December 2024

AbstractThe advancement of ethane (C2H6)‐selective materials offers the potential for developing energy‐efficient adsorptive separation processes to obtain high‐purity ethylene (C2H4) directly. However, these materials still suffer challenges of low selectivity, high cost, and poor stability. Herein, we presented a commercially scalable and stable MFI topology zeolite material (TS‐1) with excellent ideal adsorption solution theory (IAST) selectivity (2.07) and separation potential (0.64 mmol g−1). Polymer‐grade ethylene (99.9%) could be afforded with the productivity of 11.5 L kg−1 through the adsorption column packed with TS‐1 material. Additionally, pure silica zeolite with DOH topology with excellent IAST selectivity (2.93) and separation potential (1.64 mmol g−1) was discovered by high‐throughput screening via the combination of experiments and simulations. These findings highlight that pure silica zeolites hold promise as C2H6‐selective adsorbents for large‐scale implementation for one‐step C2H4 purification.
Advanced downstream processing for sustainable ethyl acetate production by fermentation
Authors: Janković Tamara , Straathof Adrie J. J. , Kiss Anton A. 
Published: December 2024

AbstractEthyl acetate is a platform chemical conventionally obtained through fossil fuel routes, but more recently its production by fermentation from carbohydrates has been scaled up to a pilot scale. Yet, the complexity of downstream processing (low product concentrations in liquid broth and in off‐gas, azeotrope formation, and the presence of microorganisms) may complicate industrial application. This original theoretical study is the first to develop advanced downstream processing, based on process intensification principles, for large‐scale recovery (~10 kton/year) of ethyl acetate after fermentation. To minimize product losses, ethyl acetate is separated from both the liquid broth and off‐gas. The final purification is performed in a highly integrated azeotropic dividing‐wall column. The economic and sustainability analysis shows that using refrigeration for initial product separation from the gas phase is more cost‐effective (~0.61 $/kg) and less energy‐intensive (2.20–2.40 kWthh/kg) than compression combined with high‐pressure condensation using chilled water (1.09 $/kg and 9.98 kWthh/kg).
Stabilizing *OH intermediate by fabricating Ni3N‐MoN for scalable 5‐hydroxymethylfurfural electrooxidation
Authors: Yang Shaowei , Guo Ying , Yang Jie , Gao Runze , Liao Zhibei , Shen Haidong , Wang Haoxi , Jiang Lifeng , Han Buxing , Zhang Qiuyu , Zhang Hepeng 
Published: December 2024

AbstractAchieving large‐scale coupling of organic electrooxidation and the hydrogen evolution reaction, while understanding the competition between organic electrooxidation and oxygen evolution reaction (OER), is a significant challenge. In this study, using Ni3N‐MoN/NF, an efficient heterojunction electrocatalyst as both anode and cathode in a 50 cm2 continuous flow reactor, we achieved a total current of ~20 A at 2.6 V. This resulted in the highest single‐pass 5‐hydroxymethylfurfural conversion efficiency (0.049 mmol cm−2 min−1) and gram‐level production of 2,5‐furandicarboxylic acid. Theoretical studies revealed that MoN accelerated *OH formation and increased its deprotonation energy barrier, leading to *OH accumulation, effectively promoting organic electrooxidation and inhibiting OER. We anticipate that our foundation in understanding the reaction mechanism and catalyst design strategy can be extended to a wider range of anodic oxidation reactions.
Identifying enablers and barriers to teleultrasound use for remote settings: A scoping review
Authors: Anderson Aubree , Theophanous Rebecca G 
Published: December 2024

AbstractIntroduction/PurposeTeleultrasound connects expert point‐of‐care ultrasound (POCUS) users with remote community and rural sites. Evolving technologies including handheld devices, upgraded image quality, and the ability to transmit over low bandwidth connections increase POCUS education, accessibility, and clinical integration. Potential teleultrasound venues include low‐resource settings, prehospital care, and austere environments (high altitudes, microgravity, conflict zones, etc.). This scoping review assesses current teleultrasound uses and identifies implementation enablers and barriers.MethodsUsing the PRISMA‐ScR checklist, PubMed, Embase, and Cochrane were searched on 16 August 2024 for teleultrasound studies. Two reviewers independently screened results and abstracted data using a data collection table. 165 articles met the following inclusion criteria: research studies describing teleultrasound, involving humans, including healthcare workers, with remote point‐of‐care or medical ultrasound use, in any setting, and in English.ResultsTeleultrasound studies were reported in most specialties and across all continents. Most were prospective (100 studies), review articles (27), or case studies (14). Study quality was variable, with 28 high quality, 77 moderate, 54 low, and 6 very low (GRADE assessment tool). Common themes that emerged include (1) type of image transmission method utilised, (2) remote provider training and curriculum development, (3) feedback methods between expert and novice users, (4) technologies and devices used, and (5) enablers and barriers to guide future teleultrasound implementation and training strategies.ConclusionOverall, the teleultrasound literature is heterogeneous in setting, design, and quality outcomes. As teleultrasound technology evolves and the use expands, future studies should standardise protocols and ensure image quality fidelity to optimise remote patient care.
Photoredox‐Catalyzed Decarboxylation of Oxetane‐2‐Carboxylic Acids and Unique Mechanistic Insights
Authors: McFee Elvis C. , Rykaczewski Katie A. , Schindler Corinna S. 
Published: December 2024

AbstractOxetanes are valuable motifs in medicinal chemistry applications, with demonstrated potential to serve as bioisosteres for an array of functional groups. Through the visible‐light‐mediated photoredox hydrodecarboxylation of 2‐aryl oxetane 2‐carboxylic acids this work enables access to the products of a [2+2]‐photocycloaddition between alkenes and aryl aldehydes without the challenges associated with a traditional UV‐light‐mediated Paternò‐Büchi reaction. Investigation into the hydrodecarboxylation mechanism reveals substrate‐dependent modes of initiation under the conditions reported herein. Divergence in diastereomeric outcome is observed, with mechanistic probes elucidating key hydrogen‐bonding and steric interactions.
Energy Transfer (EnT) Catalysis of Non‐Symmetrical Borylated Dienes: Origin of Reaction Selectivity in Competing EnT Processes
Authors: Fang Hao , García‐Eguizábal Alejandro , Hsueh Yu Jen , Daniliuc Constantin G. , Funes‐Ardoiz Ignacio , Molloy John J. 
Published: December 2024

AbstractEnergy transfer catalysis (EnT) has had a profound impact on contemporary organic synthesis enabling the construction of higher in energy, complex molecules, via efficient access to the triplet excited state. Despite this, intermolecular reactivity, and the unique possibility to access several reaction pathways via a central triplet diradical has rendered control over reaction outcomes, an intractable challenge. Extended chromophores such as non‐symmetrical dienes have the potential to undergo [2+2] cycloaddition, [4+2] cycloaddition or geometric isomerisation, which, in combination with other mechanistic considerations (site‐ and regioselectivity), results in chemical reactions that are challenging to regulate. Herein, we utilise boron as a tool to probe reactivity of non‐symmetrical dienes under EnT catalysis, paying particular attention to the impact of boron hybridisation effects on the target reactivity. Through this, a highly site‐ and regioselective [2+2] cycloaddition was realised with the employed boron motif effecting reaction efficiency. Subtle modifications to the core scaffold enabled a [4+2] cycloaddition, while a counterintuitive regiodivergence was observed in geometric isomerisation versus [2+2] cycloaddition. The observed reactivity was validated via a mechanistic investigation, determining the origin of regiodivergence and reaction selectivity in competing EnT processes.
Advanced flexible brain‐computer interfaces and devices for the exploration of neural dynamics
Authors: Zhu Pancheng , Yu Mengxia , Wu Mingzheng , Yang Yiyuan 
Published: December 2024

AbstractThe rapid advancement of flexible neural interfaces and devices is revolutionizing our ability to explore the neural foundations of consciousness, intelligence, and behavior. Cutting‐edge developments in materials science and system‐level integration are significantly enhancing the spatiotemporal resolution of neural signal acquisition and modulation, paving the way for next‐generation brain‐computer interfaces. These technologies enable unprecedented investigations into the causal relationships between neural dynamics and behaviors in freely moving subjects, offering new insights into various neurocognitive domains. The integration of artificial intelligence and brain organoids with neuroscience research promises to further decode complex neural signals, deepening our understanding of multilevel neural dynamics. Beyond their scientific implications, these innovations also offer transformative possibilities for the diagnosis, treatment, and management of neurological and psychiatric disorders. This perspective paper examines how flexible neural interfaces overcome the limitations of traditional neurotechnology, their potential impact on neural research, and their promising applications in treating neurological and psychiatric disorders, while also considering the ethical implications and future challenges in this rapidly evolving field.
Exploring the Function of OPTN From Multiple Dimensions
Authors: Guo Yanan , Tian Yixiao , Xia Peng , Zhou Xinyue , Hu Xiaohui , Guo Zhao , Ji Pengfei , Yuan Xinyi , Fu Daosen , Yin Keyu , Shen Rong , Wang Degui 
Published: December 2024

ABSTRACTAutophagy is an essential intracellular degradation system responsible for delivering cytoplasmic components to lysosomes. Within this intricate process, optineurin (OPTN), an autophagy receptor, has attracted extensive attention due to its multifaceted roles in the autophagy process. OPTN is regulated by various posttranslational modifications and actively participates in numerous signaling pathways and cellular processes. By exploring the regulatory mechanism of OPTN posttranslational modification, we can further understand the critical role of protein posttranslational modification in biological progress, such as autophagy. Additionally, OPTN is implicated in many human diseases, including rheumatoid arthritis, osteoporosis, and infectious diseases. And we delve into the inflammatory pathways regulated by OPTN and clarify how it regulates inflammatory diseases and cancer. We aim to enhance the understanding of OPTN's multifaceted functions in cellular processes and its implications in the pathogenesis of inflammatory diseases and cancer.
Solution Processable Se‐annulated Swallow Tail Perylene Bisimide Exhibiting Room Temperature Columnar Phase and Efficient Ambipolar Charge Carrier Mobility
Authors: Kumar Behera Paresh , Yadav Kajal , Roy Mrinmoy , Shankar Rao D. S. , Kumar Pandey Upendra , Sudhakar Achalkumar Ammathnadu 
Published: December 2024

AbstractThis study presents a selenium‐annulated perylene bisimide (PBI‐SeST) stabilizing room temperature columnar hexagonal phase with exceptionally low clearing temperature. The synthesis of this Se‐annulated PBI (PBI‐SeST) was accomplished using the reductive Cadogan cyclization method, with the introduction of swallow tails to reduce the clearing temperature and improve solubility. In addition, the charge carrier mobility of the Se‐bay annulated PBI is assessed by space charge limited current (SCLC) technique and juxtaposed with PBI as well as nitrogen and sulphur‐bay‐annulated PBIs. It is noteworthy that all these PBIs exhibited ambipolar charge carrier mobility, a characteristic that diverges from the prevailing literature where predominantly electron transport behavior was observed for PBIs. This distinguishes them as an exclusive category of solution‐processable, self‐assembling organic semiconductors.
Guest Diffusion Versus Recrystallization in A Single Crystal: Two Growing Mechanisms for Griseofulvin Clathrates
Authors: Spoletti Enrico , Diniz Mariana O. , Svärd Michael , Rasmuson Åke , Hudson Sarah P. , Lusi Matteo 
Published: December 2024

AbstractGriseofulvin represents a rare case of a close‐packed organic apohost that can clathrate selected volatile guests in a solid‐gas fashion. Inclusion mechanisms and solvent exchange were investigated by a combination of single crystal and powder X‐ray diffraction, coupled to optical microscopy and thermal analyses. In particular, gas diffusion and dissolution/recrystallization are alternatively observed, depending on the host polymorph, as well as the chemical nature of the guest and its physical state.
Near‐Quantitative Removal of Oxalate and Terephthalate from Water by Precipitation with a Rigid Bis‐Amidinium Compound
Authors: Goodwin Rosemary J. , Muang‐Non Phonlakrit , Tzioumis Nikki A. , Jolliffe Katrina A. , White Nicholas G. 
Published: December 2024

AbstractA simple, readily‐prepared precipitant (1⋅Cl2) precipitates oxalate or terephthalate from water with very high efficacy, removing these anions at sub‐millimolar concentrations using only one equivalent of precipitant. A simple aqueous base/acid cycle can be used to regenerate 1⋅Cl2 after use. The resulting precipitates, 1⋅oxalate and 1⋅terephthalate, are anhydrous and closely‐packed, with each anion receiving eight charge‐assisted hydrogen bonds from amidinium N−H donors. Precipitation of oxalate and terephthalate occurs at much lower concentrations than other dicarboxylates, and direct competition experiments with the biologically/environmentally relevant divalent anions CO32−, HPO42− and SO42− reveal very high selectivity for oxalate or terephthalate over these competitors.
Titania immobilized over Fe‐functionalized beta and silicalite zeolites for tetracycline photocatalytic degradation under visible light
Authors: Jalloul Ghadeer , Hijazi Nour , Awala Hussein , Boyadjian Cassia , Albadarin Ahmad B. , Ahmad Mohammad N. 
Published: December 2024

AbstractTitania photocatalyst is widely employed in the removal of organic pollutants from water streams. However, TiO2 suffers from agglomeration and is mostly active under UV light resulting in low system efficiency. In this study, we prepared sol–gel TiO2 immobilized on beta (BEA) and silicalite zeolites for the photocatalytic degradation of tetracycline antibiotics under visible light. Ferric ions were incorporated into the supported Titania photocatalyst via ion exchange method to enhance its visible light absorption. The deposition of the Titania over BEA zeolite greatly enhanced its adsorption efficiency (from 5.6% to 24%) and surface area (from 90 to 305.9 m2/g) while silicalite support only slightly affected the adsorption of Titania. The scanning electron microscope (SEM) characterization of the photocatalysts indicated that the zeolite structure was conserved after modification and the UV–VIS DRS characterization confirmed the enhancement of visible light absorption. The TiO2/Fe‐Beta was able to degrade 100% of tetracycline (TC) in solution under blue light after 90 min compared to only 30% by TiO2/Fe‐silicalite and 28% by TiO2. When the weight percentage of TiO2 in the TiO2/Fe‐silicalite photocatalyst increased from 20% to 60%, its efficiency increased from 87% to 99% after 300 min. Similar results were also obtained under white light, where the TiO2/Fe‐Beta achieved the highest efficiency (81.5%) as compared to TiO2/Fe‐silicalite (66.6%) and TiO2 (44.7%). We attribute this enhanced performance of TiO2/Fe‐Beta to enhanced adsorption capacity due to BEA immobilization and improved visible light absorption.