bluuebunny/crossref_metadata_2025_split huggingface dataset:
18F-FDG accumulation in less-affected lung area predicts postoperative interstitial lung disease acute exacerbation in lung cancer: A case control study
Authors: Fukunaga Kentaro , Nagatani Yukihiro , Nakagawa Hiroaki , Nitta-Seko Ayumi , Nagata Tamotsu , Nishizono Masaki , Kobashi Kazumasa , Iguchi Harumi , Nitta Norihisa , Hanaoka Jun , Murata Kiyoshi , Nakano Yasutaka 
Published: April 2020

Abstract
Background: Pneumonectomy for lung cancer with interstitial lung disease (ILD) has been shown to cause postoperative acute exacerbation (AE) of the ILD. The accumulation of 18F-flurodeoxyglucose (FDG) on normal parenchymal or less-affected lung fields in 18F-FDG-positron emission tomography (PET)/computed tomography (CT) has been reported to be related to ILD disease activity and prognosis. To determine whether 18F-FDG accumulation in normal parenchymal or less-affected lung fields on 18F-FDG-PET/CT can predict postoperative AE of ILD in non-small cell lung cancer (NSCLC) patients with ILD.Methods: This retrospective study included 36 NSCLC patients with ILD, who underwent 18F-FDG-PET/CT at 2 institutions before pulmonary surgery. A single volume-of-interest (VOI) was placed to measure the mean standardized uptake value (SUVmean) in normal or less-affected lung fields at 12 areas on the ventral and dorsal locations of both lungs, in each level of the aortic arch, tracheal bifurcation, and the orifice of the right lower pulmonary vein into the left atrium. The region to which the target VOI was set corresponded to no or minimally increased attenuation on high resolution CT. The SUVmean was defined as the mean SUV of the target VOI, SUVtissue fraction (TF) as the corrected SUVmean by using TF and mean computed tomography density (CTDmean) as the mean attenuation of the corresponding target VOI on HRCT. We performed a phantom study to optimize SUV difference among 2 institutions. The corrected SUVmean (cSUVmean) and corrected SUVTF (cSUVTF) were calculated based on the phantom study result.Results: Among 36 NSCLC patients with ILD who underwent pulmonary surgery, 8 patients developed postoperative AE of ILD. The cSUVmean values in the ventral and dorsal locations at the aortic arch level, and in the ventral location at the tracheal bifurcation level in the group with postoperative AE were higher than in the group without postoperative AE. There was no significant difference in the value of cSUVTF and CTDmean between the groups with and without postoperative AE.Conclusion: 18F-FDG accumulation in the normal or less-affected lung fields can potentially predict postoperative AE of ILD in NSCLC patients with ILD.
Prevalence and correlates of Multimorbidity among older adults in rural Nepal: a cross sectional study
Authors: Yadav Uday Narayan , Ghimire Saruna , Mistry Sabuj Kanti , Shanmuganathan Selvanaayagam , Rawal Lal Bahadur , Harris Mark Fort 
Published: April 2020

Abstract
Background Multimorbidity among older adults is an increasing challenge for health systems. Compared to a single disease condition, multimorbidity lowers the quality of life and experience higher hospital admission and health care expenditure. Although multimorbidity has gained global attention, it remains a less studied area in Nepal. Our study aimed to estimate the prevalence of major chronic diseases and multimorbidity among older adults in rural Nepal and examine the associated socioeconomic and behavioral risk factors.Methods We analyzed data of 794 Nepalese older adults recruited using a multi-stage cluster sampling approach in two rural setting of Sunsari and Morang District of Nepal. This was a cross-sectional study, conducted between January to April 2018. Socio-demographics and health conditions data [ Osteoarthritis, Cardiovascular diseases (CVD), Diabetes, Chronic Obstructive Pulmonary Diseases (COPD) ] were collected through the help of trained research assistants using a validated questionnaire. The correlates of multimorbidity were examined using mixed-effects logistic regression.Results 48.9% of the participants had at least one chronic condition, and 14% were multimorbid. The prevalence of individual conditions were osteoarthritis- 41.7%, CVD- 2.39%, diabetes- 5.29%, and COPD- 15.7%. In the adjusted model, older adults aged 70-79 years, those from underprivileged Madhesi and other ethnic groups, without a history of alcohol drinking, and those physically inactive, were significantly associated with multimorbidity.Conclusion Our study found a sizeable proportion of the older adults had multimorbidity in our studied population. This prevalence of multimorbidity and its socioeconomic and behavioural correlates, need to be addressed through multi-level preventive strategies, including clinical guidelines and the development of a multidisciplinary workforce to address the needs of the multimorbid older adults.
Robotic surgery using a DROP-IN beta probe – feasibility study with 68Ga-PSMA in prostate cancer specimens
Authors: Collamati Francesco , Oosterom Matthias van , Simoni Micol De , Faccini Riccardo , Fischetti Marta , Mancini-Terracciano Carlo , Mirabelli Riccardo , Moretti Roberto , Heuvel Judith olde , Solfaroli-Camillocci Elena , Beurden Florian van , Poel Henk van der , Olmos Renato Valdes , Leeuwen Pim van , Leeuwen Fijs van , Morganti Silvio 
Published: April 2020

Abstract
Background: Recently, a flexible DROP-IN gamma-probe was introduced for robot-assisted radioguided surgery, using traditional low-energy SPECT-isotopes. This study explores the use of a novel DROP-IN beta-particle (DROP-IN b ) detection probe to support the implementation of the large number of PET-tracers available during robot-assisted tumor-receptor-targeted resections. Methods: Following engineering of the DROP-IN b probe, robotic implementation was investigated using surgical specimens. Seven prostate cancer patients with PSMA-PET positive tumors received an intraoperative injection of ~100 MBq 68 Ga-PSMA-11, followed by prostatectomy and extended pelvic lymph node dissection. Results: The probe was able to identify the position of the tumor in the prostate specimens: S/B was > 5 when pathology confirmed that the tumor was located <1 mm below the specimen surface. PSMA-PET positive lymph nodes, as found in two patients, could be identified with the DROP-IN b probe (S/B>3). Conclusions: This ex vivo study underlines the potential to use a DROP-IN b probe for intraoperative tumor identification on the prostate surface and confirmation of PSMA-PET positive lymph nodes.
Associations between Workplace Violence, Mental Health and Physical Health among Korean Employees: The Fifth Korea Youth Working Conditions Survey (2017)
Authors: Kim Hae Ran 
Published: April 2020

Abstract
Background This study assessed workplace violence experiences among Korean employees and its influence on mental and physical health.Methods Using the 2017 Fifth Korea Youth Working Conditions Survey, 50,205 workers were analyzed. Experiences of workplace violence were assessed across four categories: verbal violence, unwanted sexual attention, threatening behavior, and humiliation. Mental health included anxiety, sleep problems, depressive symptoms, and physical health included hearing loss/dermatological problems, back pain, limbs myalgia, headache/eye stain, occupational injury, and overall fatigue.Results Experience of workplace violence was more common among workers with poor health (subjectively measured), chronic disease, long weekly working hours, shift work, or jobs in the service industry. Experience of workplace violence was associated with increased anxiety, sleep problems, depression symptoms, and physical health problems.Conclusions Prevention of workplace violence is essential to improve the health of workers.
Assessing the Impact of Biologically Synthesized ZnO Nanoparticles as Source of Nutrient on the Growth of Zea mays L.
Authors: Sabir Sumera , Zahoor Muhammad Asif , waseem Muhammad , Siddique Muhammad Hussnain , Shafique Muhammad , Imran Muhammad , Hayat Sumreen , Malik Imran Riaz , Muzammil Saima 
Published: April 2020

Abstract
Nano-fertilizer(s), an emerging field of agriculture, is alternate option for enhancement of plant growth replacing the synthetic fertilizers. For example, zinc oxide nanoparticles (ZnO NPs) can be used as the zinc source for plants. The present investigation was carried out to assess the role of ZnO NPs in growth promotion of maize plants. ZnO NPs were synthesized using Bacillus sp ., which were characterized using Scanning Electron Microscope (SEM), Transmission Electron Microscope (TEM) and X-ray diffraction (XRD). The different concentrations of ZnO NPs ( i . e . 0, 2, 4, 6, 8, 16 mg/L) for growth enhancement of maize ( Zea mays L.) were explored in pot culture experiment. It was observed that size of ZnO NPs ranged between 16 and 20 nm. A significant increase in growth parameters like shoot length (61.7 %), root length (56.9 %) and significantly higher level of protein was observed in the treated plants as compared to control The overall pattern for growth biomarkers including the protein contents was maximum at 8mg/L of ZnO NPs. It was observed that application of biologically synthesized ZnO NPs has improved majority of growth biomarkers including plant growth parameters, protein contents and leaf area. All these parameters were positively influenced by ZnO NPs. Therefore, biosynthesized ZnO NPs could be considered as an alternate source of nutrient in Zn deficient soils for promoting the modern agriculture.
An effector-reporter system to study cellular cellular signal transduction in strawberry fruit (Fragaria ananassa)﻿
Authors: Zeng Baozhen , Li Tianyu , Wang Wei , Dai Zhengrong , Li Jie , Xi Zhiyuan , Jia Kenan , Xing Yu , Li Bingbing , Yan Jiaqi , Jia Wensuo 
Published: April 2020

Abstract
Background: An effector-reporter system is a powerful tool used to study cellular signal transduction; however, this technique has been traditionally adopted in protoplasts. A similar system to study cellular signal transduction in fruits has not yet been established. In this paper, we aim to establish an effector-reporter system for strawberry fruit, a model non-climacteric fruit.Results: We compared four different reporters, including GUS, GFP, FLuc, and RLuc, as well as combination of two pairs of reporters, including GUS/GFP and RLuc/FLuc, by statistically analyzing the pattern of reporter activities exhibited among individual fruits. Among the reporters examined, GUS was the best choice. Further sampling indicated that a minimum of five mixed specimens with five fruits each is necessary for an assay. With the so-established system, FaCHS promoter demonstrated a sensitive response to FaMYB10 effector as well as to the external and internal cues implicated in the regulation of fruit ripening.Conclusion: A step-by step protocol was established to study cellular signal transduction in strawberry fruits. This finding will contribute to the molecular investigation of fruit ripening.
Epidemiology and Detection of Multiple Drug-Resistant Trypanosoma congolense in Zebu Cattle in Gurage Zone, Southwest Ethiopia
Authors: Tekle Tilahun , Tesfaye Asamenew 
Published: April 2020

Abstract
Background Trypanosomosis in animal is a major threat for the development of livestock sector in many Africa countries as a result it contributes for the prevailing severe hunger and poverty in most sub-Saharan African countries. The aim of this study is to determine the prevalence and drug susceptibility pattern of Trypanosoma congolense in selected districts in Gurage zone, Ethiopia. Methods A cross-sectional study was carried out in 2000 selected indigenous cattle and eighty (n=80) cattle were selected out of 2000 to carry out drug susceptibility test using longitudinal study. Animals were grouped equally into two (n=40) treatment groups and treated with isometamidium chloride (ISMM) and diminazene aceturate (DIM) according to the manufacturer’s instruction. Sample was collected and the microhaematocrit centrifugation technique was used to determine PCV while trypanosomes were detected using dark-ground phase-microscopy. Results The overall prevalence of trypanosomosis was 4.50% (95% CI=4.28, 4.72) and significantly different among districts (P<0.05) where the highest prevalence (7.1%) was recorded in Abeshege district. The mean PCV for cattle in the longitudinal study (n=80) was 23.2 (95%CI=22.3, 24) with no significance (P>0.05) among the study villages. An overall 37.5% (30/80) drug failure rate was recorded at day 14 post treatment. The failure rate accounted 27.5% (11/40) and 47.5% (19/40) for ISMM and DIM at 14 days post-treatment respectively. Those persistently infected cattle at day 14 were re-treated by exchanging the drug and revealed a failure rate of 26.3% (5/19) and 54.5% (5/11) for ISMM and DA respectively. The mean PCV was variable (P<0.05) before applying treatment (day 0=23.2) and day 28 (PCV=25.09). Conclusions The study revealed that T. congolense developed resistance to ISM and DIM at the given dosage regimen. Therefore, an integrated control approach against the parasite and vectors should be implemented in the area.
Penentuan Waktu Relaksasi Pertukaran Gas, Koefisien Difusi dan Resistensi Buah Tomat terhadap C2H4 Menggunakan Spektrometer Fotoakustik Laser CO2 dengan Pelacak Gas SF6
Authors: Wasono Moh Ali Joko , Kholishoh Y. A. 
Published: April 2020

Telah dilakukan studi metode penentuan waktu relaksasi, koefisien resistansi dan koefisien difusi pertukaran gas SF6 di dalam buah tomat (Lycopersicon esculentum) dengan metode spektroskopi fotoakustik laser CO2 yang bersifat tidak mengganggu dan tidak merusak sampel buah. Gas SF6 menyerap paling kuat pada garis laser 10P16 dan gas C2H4 pada garis laser 10P14 dengan frekuensi resonansi sebesar (1650 ± 5) Hz. Batas deteksi terendah yang dihasilkan oleh spektrometer tsb untuk gas SF6 diperoleh (2; 6 ± 0; 4) ppt dan untuk gas C2H4 sebesar (0; 32 ± 0; 03) ppb. Sesudah diketemukan paramater difusi utk gas pelacak SF6, maka dapat ditentukan parameter difusi untuk hormon pematangan buah, gas C2H4. Sifat-sifat Metode pemantauan difusi gas SF6 pada buah tomat serta pengukuran emisi gas C2H4 dalam kurun waktu 15 hari menghasilkan pola karakteristik waktu relaksasi & koefisien resistansi serta koefisen difusi terhadap emisi etilen. Diperoleh hasil pola emisi C2H4 menunjukkan kurva sesuai dengan yang dimiliki buah klimakterik. Hasil pemantauan gas SF6 ditemukan kecenderungan waktu relaksasi dan koefisien resistensi buah terhadap gas SF6 menurun secara eksponensial dengan berjalannya waktu umur buah tomat. Adapun koefisien difusi mengalamai kenaikan secara eksponensial juga. Dari hasil perolehan transportasi gas didalam buah tomat menentukan metabolisme yangberkaitan langsung dengan penyimpanan buah Hal ini dapat direkomendasikan kepada pengelola pengendalian pematangan buah tomat untuk mendapatkan optimasi parameter difusi sehingga diperoleh pematangan sesuai dengan kebutuhan pasar.
Perancangan Aplikasi Rute Bus AKDP Di Provinsi Jawa Timur Berbasis Android
Authors: Nugroho Irfan Agung , Masykur Fauzan , Astuti Indah Puji 
Published: April 2020

Transportasi di definisikan sebagai kegiatan pemindahan penumpang dan barang dari suatu tempat ke tempat lain,dimana didalamnya terdapat unsur pergerakan.Masyarakat sangat bergantung dengan adanya alat transportasi sebagai media pendukung dalam kehidupan sehari hari. Kendaraan jenis Bus diminati masyarakat karena tarifnya yang murah. Untuk membantu masyarakat dalam melakukan pencarian bus dari rute yang diinginkan tersebut, maka dibuatlah aplikasi pencarian rute bus AKDP di Provinsi Jawa Timur ini dengan berbasis android. Hasil yang dicapai dalam penelitian ini masyarakat dapat terbantu dengan adanya aplikasi pencarian rute bus AKDP di Provinsi Jawa Timur ini.
CSR categories and R&D investment: the moderating role of Managerial emotional intelligence
Authors: Ezzi Ferdaws , Jarboui Anis , Zouari-Hadiji Rim 
Published: April 2020

Abstract
The purpose of this paper was to determine the important role of Chief Executive Officer emotional intelligence to explain the interaction relationship between research and development investment and corporate social responsibility categories. This research relied on the completion of a questionnaire type inquiry structured around the table-based analysis. The questionnaire was sent out to a large sample of Tunisian firms’ Chief Executive Officer. The results of the 96 valid responses were entered for analysis by the partial least squares method. They show the significant effect of Chief Executive Officers’ emotional intelligence on the relation between corporate social responsibility categories (customer, employee, community, territory and environment) and research and development investment. In addition, the Chief Executive Officer emotional intelligence provided explanations into research and development investment for the corporate social responsibility problems in Tunisia. Firstly, this study emphasized the important role of research and development investment in the corporate social responsibility categories. Secondly, a new data analysis method “decision-tree” was applied to estimate the moderating effects of managerial emotional intelligence on the CSR – R&D relationship.
Efektivitas Penggunaan Aplikasi Qraved sebagai Media Memilih Tempat Makan
Authors: Putri Nadia Qisthina 
Published: April 2020

Perkembangan internet mendorong munculnya berbagai aplikasi baru mulai dari Instagram, Facebook maupun lainnya. Pengertian media menurut pengertian ahli adalah segala bentuk dan saluran yang digunakan untuk menyampaikan informasi atau pesan. Media juga dapat diakses sebagai jasa informasi, dalam hal ini untuk memilih tempat makan yang dinamakan aplikasi Qraved. Qraved didirikan pada tahun 2013, merupakan perusahaan direktori reservasi kuliner yang dinilai berhasil memberikan solusi “Makan apa dan dimana”. Tujuan dari penelitian ini untuk mengetahui efektivitas penggunaan aplikasi Qraved bagi masyarakat dalam meilih tempat makan. Jenis penelitian ini adalah kuantitatif. Pengukuran efektivitas menggunakan metode penyebaran kuesioner dengan tujuan yaitu mengukur perilaku konsumen. Data dikumpulkan menggunakan kuesioner yang telah diujivaliditas dan realibilitasnya. Sampel penelitian ini diambil sebanyak 100 orang pengguna aplikasi Qraved. Dengan penelitian kuantitatif deskriptif peneliti mengukur efektifitas dari aplikasi Qraved menggunaan model komunikasi EPIC Model yaitu mengukur efektivitas dari segi empathy, persuation, impact dan communication. Hasil menunjukkan bahwa aplikasi Qraved efektif dalam membantu masyarakat memilih tempat makan.
The Moral Law and The Good in Temporal Modal Logic with Propositional Quantifiers
Authors: Rönnedal Daniel 
Published: April 2020

The Moral Law is fulfilled (in a possible world w at a time t) iff (if and only if) everything that ought to be the case is the case (in w at t), and The Good (or The Highest Possible Good) is realised in a possible world w' at a time t' iff w' is deontically accessible from w at t. In this paper, I will introduce a set of temporal alethic deontic systems with propositional quantifiers that can be used to prove some interesting theorems about The Moral Law and The Good. First, I will describe a set of systems without any propositional quantifiers. Then, I will show how these systems can be extended by a couple of propositional quantifiers. I will use a kind of TxW semantics to describe the systems semantically and semantic tableaux to describe them syntactically. Every system will include a constant · that stands for The Good. ‘·’ is read as ‘The Good is realised’. All systems that contain the propositional quantifiers will also include a constant '*' that stands for The Moral Law. '*' is read as ‘The Moral Law is fulfilled’. I will prove that all systems (without the propositional quantifiers) are sound and complete with respect to their semantics and that all systems (including the extended systems) are sound with respect to their semantics. It is left as an open question whether or not the extended systems are complete.
New Zealand Trustee Investing: Reflecting on Modern Portfolio Theory and the Ancient Distinction of Principal and Income
Authors: Manns Jr F Philip 
Published: April 2020

The New Zealand Trustee Amendment Act 1988 led the common law world in encouraging (perhaps requiring) trustees to use modern portfolio theory ("MPT") techniques when investing trust funds. A recent High Court decision essentially held that trustees should have engaged in MPT-based investment since 1972. Full integration of MPT principles into trust law affects many areas of trust administration, perhaps most prominently the ancient distinction of principal and income. In addition, renewed attention to careful drafting of a settler's investment and pay out intentions and greater investment diversification are likely consequences of MPT-based trust investing.
Predatory Conduct under the Commerce Act 1986
Authors: Coull David 
Published: April 2020

This article examines the significance of the Court of Appeal's decision in Commerce Commission v Port Nelson Limited. The Court's analysis of predatory pricing, "bundling" and the tug tie is explored. The article concludes that the effect of the Court of Appeal's decision is to significantly widen the scope of section 27 of the Commerce Act. This is contrasted with the restrictive interpretation that recent courts have accorded section 36. The article concludes that court decisions have fundamentally changed the scheme of the Commerce Act 1986.
Digitale Zwillinge und Digitale Zwillingspaare im Kontext des Digital Engineerings
Authors: Miehling Jörg , Schleich Benjamin , Wartzack Sandro 
Published: April 2020

Kurzfassung
Neben der gezielten Nutzung von Daten und Informationen aus dem gesamten Produktlebenszyklus stellt die Integration des Nutzers und die Absicherung der Nutzer-Produkt-Interaktion im Digital Engineering eine wesentliche Herausforderung dar. Motiviert hierdurch beleuchtet der vorliegende Beitrag wesentliche Potentiale digitaler Zwillinge im Kontext des Digital Engineerings und stellt das Konzept des Digitalen Zwillingspaares als Möglichkeit der digitalen Einbindung des Nutzers in den Produktentstehungsprozess vor.
Comprensión lectora y rendimiento de matemáticas
Authors: Soto Dayan Reyes 
Published: April 2020

En Chile, diversos estudios intentan determinar los factores que intervienen en la comprensión lectora a un nivel académico, personal y familiar dado los bajos resultados que tienen los estudiantes en las mediciones nacionales e internacionales que se realizan periódicamente. El presente estudio tiene como propósito describir la relación entre comprensión lectora y rendimiento académico en la asignatura de matemáticas en estudiantes de 4° medio de un establecimiento particular-subvencionado de la ciudad de Chillán, Chile.
Mediante una metodología cuantitativa, con un diseño no experimental transversal y un alcance descriptivo-correlacional, se evalúo el porcentaje de comprensión lectora con el procedimiento cloze a 151 estudiantes que cursaban 4° medio. Los desempeños de dicha evaluación se correlacionaron con los promedios de matemáticas obtenidos por dichos estudiantes durante el primer semestre académico. Los resultados indican que existe una relación significativa de tipo fuerte y bidireccional entre las variables, tanto en sus mediciones numéricas como en las categóricas.