bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regional Food Hubs For Distribution of Regional Food Logistics (Case Study on the Establishment of a Food Distribution Center in Banten Province, Indonesia)
Authors: Winarno H , Perdana T , Handayati Y , Purnomo D 
Published: March 2020

Abstract
Agriculture has a strategic role in sustaining the economy of a region, especially in improving food security and production of agricultural products. Food Hubs plays the role of building a food system that is capable of aggregating, distributing and connecting farmers with consumers directly. This requires the role and management of effective distribution methods by integrating the roles of farmers and consumers in a distribution center. The Distribution Center (DC) is managed by a Regional-Owned Enterprise (BUMD) that assists farmers in producing, selling and distributing food. Distribution Centers are able to overcome the problem of stock scarcity, price disparity, and price fluctuations in goods - especially staples. The Food hubs are supported by the determination of the number of warehouses, warehouse locations, and warehousing standards for the management of food staple inventory warehouses. Besides determining the level of inventory of safe food staples (buffer stock) is based on the main parameters: lead time and demand requirements. Food Hubs Operations embody the role of farmers, traders, in supporting the activities of distribution centers managed by Regional owned enterprises. Food hubs interactions involve institutions that play a role in sustaining these activities.
One pot synthesis of ZnO hexagonal bugle beads in a closed polypropylene vessel: a simple hydrothermal way of synthesizing nanocrystalline ZnO photocatalyst for waste water treatments
Authors: Malik Khurshaid Ahmad , Tomar Radha , Malik Javied Hamid , Zaman M Burhanuz 
Published: March 2020

Abstract
Here, we report a novel and eco-friendly synthesis of zinc oxide (ZnO) hexagonal bugle beads in a closed polypropylene vessel. To the best of our knowledge, we are the first to report synthesis of ZnO nanostructures in a closed polypropylene vessel (a simple hydrothermal reactor). Structural, morphological, compositional and optical properties of the nanostructures were studied. X-ray diffraction (XRD) results demonstrate that ZnO nanocrystals grow in a single crystalline hexagonal phase. Scanning electron microscopy (SEM) reveal formation of nano-dimensional hexagonal bugle beads (base diameter ∼70 nm). The ZnO nanostructures were used to carry photocatalytic degradation of methylene blue (MB) dye. The beads show high photocatalytic performance against MB dye and degraded 89% of the dye in 120 min of UV light irradiation. The reusability test of zinc oxide bugle beads determine high stability of the photocatalyst.
Prenatal Treatment of Congenital Cytomegalovirus With Valganciclovir: A Case Report
Authors: DeNoble Anna E , Saccoccio Frances M , Permar Sallie R , Hughes Brenna L 
Published: March 2020

Abstract
Cytomegalovirus (CMV) is the most common congenital infection and infectious cause of fetal anomaly and neurologic injury. However, treatment strategies for congenital CMV (cCMV) infection during pregnancy remain elusive. We report a case of hydrops fetalis secondary to cCMV infection with minimal sequelae after maternal and subsequent neonatal treatment with valganciclovir.
Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19)
Authors: Guo Li , Ren Lili , Yang Siyuan , Xiao Meng , Chang De , Yang Fan , Dela Cruz Charles S , Wang Yingying , Wu Chao , Xiao Yan , Zhang Lulu , Han Lianlian , Dang Shengyuan , Xu Yan , Yang Qi-Wen , Xu Sheng-Yong , Zhu Hua-Dong , Xu Ying-Chun , Jin Qi , Sharma Lokesh , Wang Linghang , Wang Jianwei 
Published: March 2020

Abstract

Background
The emergence of coronavirus disease 2019 (COVID-19) is a major healthcare threat. The current method of detection involves a quantitative polymerase chain reaction (qPCR)–based technique, which identifies the viral nucleic acids when present in sufficient quantity. False-negative results can be achieved and failure to quarantine the infected patient would be a major setback in containing the viral transmission. We aim to describe the time kinetics of various antibodies produced against the 2019 novel coronavirus (SARS-CoV-2) and evaluate the potential of antibody testing to diagnose COVID-19.

Methods
The host humoral response against SARS-CoV-2, including IgA, IgM, and IgG response, was examined by using an ELISA-based assay on the recombinant viral nucleocapsid protein. 208 plasma samples were collected from 82 confirmed and 58 probable cases (qPCR negative but with typical manifestation). The diagnostic value of IgM was evaluated in this cohort.

Results
The median duration of IgM and IgA antibody detection was 5 (IQR, 3–6) days, while IgG was detected 14 (IQR, 10–18) days after symptom onset, with a positive rate of 85.4%, 92.7%, and 77.9%, respectively. In confirmed and probable cases, the positive rates of IgM antibodies were 75.6% and 93.1%, respectively. The detection efficiency by IgM ELISA is higher than that of qPCR after 5.5 days of symptom onset. The positive detection rate is significantly increased (98.6%) when combining IgM ELISA assay with PCR for each patient compared with a single qPCR test (51.9%).

Conclusions
The humoral response to SARS-CoV-2 can aid in the diagnosis of COVID-19, including subclinical cases.
Tenacious Endemic Typhoid Fever in Samoa
Authors: Sikorski Michael J , Desai Sachin N , Tupua Siaosi , Thomsen Robert E , Han Jane , Rambocus Savitra , Nimarota-Brown Susana , Punimata Linatupu , Tusitala Salesa , Sialeipata Michelle , Hoffman Seth A , Tracy J Kathleen , Higginson Ellen E , Tennant Sharon M , Gauld Jillian S , Klein Daniel J , Ballard Susan A , Robins-Browne Roy M , Dougan Gordon , Nilles Eric J , Howden Benjamin P , Crump John A , Naseri Take K , Levine Myron M 
Published: March 2020

Abstract

Background
Typhoid fever has been endemic on the island nation of Samoa (2016 population, 195 979) since the 1960s and has persisted through 2019, despite economic development and improvements in water supply and sanitation.

Methods
Salmonella enterica serovar Typhi isolates from the 2 hospitals with blood culture capability and matched patient demographic and clinical data from January 2008 through December 2019 were analyzed. Denominators to calculate incidence by island, region, and district came from 2011 and 2016 censuses and from 2017–2019 projections from Samoa’s Bureau of Statistics. Data were analyzed to describe typhoid case burden and incidence from 2008 to 2019 by time, place, and person.

Results
In sum, 53–193 blood culture-confirmed typhoid cases occurred annually from 2008 to 2019, without apparent seasonality. Typhoid incidence was low among children age &lt; 48 months (17.6–27.8/105), rose progressively in ages 5–9 years (54.0/105), 10–19 years (60.7–63.4/105), and 20–34 years (61.0–79.3/105), and then tapered off; 93.6% of cases occurred among Samoans &lt; 50 years of age. Most typhoid cases and the highest incidence occurred in Northwest Upolu, but Apia Urban Area (served by treated water supplies) also exhibited moderate incidence. The proportion of cases from short-cycle versus long-cycle transmission is unknown. Samoan S. Typhi are pansusceptible to traditional first-line antibiotics. Nevertheless, enhanced surveillance in 2019 detected 4 (2.9%) deaths among 140 cases.

Conclusions
Typhoid has been endemic in Samoa in the period 2008–2019. Interventions, including mass vaccination with a Vi-conjugate vaccine coadministered with measles vaccine are planned.
Diversified Farming in a Monoculture Landscape: Effects on Honey Bee Health and Wild Bee Communities
Authors: St. Clair Ashley L , Zhang Ge , Dolezal Adam G , O’Neal Matthew E , Toth Amy L 
Published: March 2020

AbstractIn the last century, a global transformation of Earth’s surface has occurred due to human activity with extensive agriculture replacing natural ecosystems. Concomitant declines in wild and managed bees are occurring, largely due to a lack of floral resources and inadequate nutrition, caused by conversion to monoculture-based farming. Diversified fruit and vegetable farms may provide an enhanced variety of resources through crops and weedy plants, which have potential to sustain human and bee nutrition. We hypothesized fruit and vegetable farms can enhance honey bee (Hymenoptera: Apidae, Apis mellifera Linnaeus) colony growth and nutritional state over a soybean monoculture, as well as support a more diverse wild bee community. We tracked honey bee colony growth, nutritional state, and wild bee abundance, richness, and diversity in both farm types. Honey bees kept at diversified farms had increased colony weight and preoverwintering nutritional state. Regardless of colony location, precipitous declines in colony weight occurred during autumn and thus colonies were not completely buffered from the stressors of living in a matrix dominated with monocultures. Contrary to our hypothesis, wild bee diversity was greater in soybean, specifically in August, a time when fields are in bloom. These differences were largely driven by four common bee species that performed well in soybean. Overall, these results suggest fruit and vegetable farms provide some benefits for honey bees; however, they do not benefit wild bee communities. Thus, incorporation of natural habitat, rather than diversified farming, in these landscapes, may be a better choice for wild bee conservation efforts.
Cannabis use and the sperm epigenome: a budding concern?
Authors: Schrott Rose , Murphy Susan K 
Published: March 2020

AbstractThe United States is swiftly moving toward increased legalization of medical and recreational cannabis. Currently considered the most commonly used illicit psychoactive drug, recreational cannabis is legal in 11 states and Washington, DC, and male use is an important and understudied concern. Questions remain, however, about the potential long-term consequences of this exposure and how cannabis might impact the epigenetic integrity of sperm in such a way that could influence the health and development of offspring. This review summarizes cannabis use and potency in the USA, provides a brief overview of DNA methylation as an epigenetic mechanism that is vulnerable in sperm to environmental exposures including cannabis, and summarizes studies that have examined the effects of parental exposure to cannabis or delta-9 tetrahydrocannabinol (THC, the main psychoactive component of cannabis) on the epigenetic profile of the gametes and behavior of offspring. These studies have demonstrated significant changes to the sperm DNA methylome following cannabis use in humans, and THC exposure in rats. Furthermore, the use of rodent models has shown methylation and behavioral changes in rats born to fathers exposed to THC or synthetic cannabinoids, or to parents who were both exposed to THC. These data substantiate an urgent need for additional studies assessing the effects of cannabis exposure on childhood health and development. This is especially true given the current growing state of cannabis use in the USA.
Postoperative but not intraoperative transfusions are associated with respiratory failure after pneumonectomy
Authors: Kidane Biniam , Jacob Nithin , Bruinooge Allan , Shen Yu Cindy , Keshavjee Shaf , dePerrot Marc E , Pierre Andrew F , Yasufuku Kazuhiro , Cypel Marcelo , Waddell Thomas K , Darling Gail E 
Published: March 2020

Abstract

OBJECTIVES

Transfusion of blood products has been associated with increased risk of post-pneumonectomy respiratory failure. It is unclear whether intraoperative or postoperative transfusions confer a higher risk of respiratory failure. Our objective was to assess the role of transfusions in developing post-pneumonectomy respiratory failure.

METHODS
We performed a retrospective cohort study using prospectively collected data on consecutive pneumonectomies between 2005 and 2015. Patient records were reviewed for intraoperative/postoperative exposures. Univariable and multivariable analyses were performed.

RESULTS
Of the 251 pneumonectomies performed during the study period, 24 (9.6%) patients suffered respiratory failure. Ninety-day mortality was 5.6% (n = 14) and was more likely in patients with respiratory failure (7/24 vs 7/227, P &lt; 0.001). Intraoperative and postoperative transfusions occurred in 42.2% (n = 106) and 44.6% (n = 112) of patients, respectively and were predominantly red blood cells. On univariable analysis, both intraoperative (P = 0.03) and postoperative transfusion (P = 0.004) were associated with a higher risk of respiratory failure. The multivariable model significantly predicted respiratory failure with an area under curve (AUC) = 0.88 (P = 0.001). On multivariable analysis, the only independent predictors of respiratory failure were postoperative transfusions [adjusted odds ratio (aOR) 6.54, 95% confidence interval (CI) 1.74–24.59; P = 0.005] and lower preoperative forced expiratory volume (adjusted OR 0.96, 95% CI 0.93–0.99; P = 0.03). Estimated blood loss was not significantly different (P = 0.91) between those with (median 800 ml, interquartile range 300–2000 ml) and without respiratory failure (median 800 ml, interquartile range 300–2000 ml).

CONCLUSIONS
Respiratory failure occurred in 9.6% of patients post-pneumonectomy and confers a higher risk of 90-day mortality. Postoperative (but not intraoperative) transfusion was the strongest independent predictor associated with respiratory failure. Intraoperative transfusion may be in reaction to active/unpredictable blood loss and may not be easily modifiable. However, postoperative transfusion may be modifiable and potentially avoidable. Transfusion thresholds should be assessed in light of potential cost-benefit trade-offs.
Aortic remodelling after thoracic endovascular aortic repair in acute and chronic type B aortic dissections
Authors: Dohle Daniel-Sebastian , Laverne Travis , Bavaria Joseph , Savino Danielle , Vallabhajosyula Prashant , Szeto Wilson Y , Siki Mary , Wang Grace , Jackson Benjamin , Desai Nimesh 
Published: March 2020

AbstractOBJECTIVESType B aortic dissections are routinely treated with thoracic endovascular aortic repair (TEVAR). The timing for TEVAR remains controversial and might have an impact on the remodelling capacity of the aorta. This study analyses and compares aortic remodelling in acute (ABD) and chronic (CBD) type B aortic dissections after TEVAR.METHODSThis retrospective study analysed the preoperative, postoperative and at least 1-year follow-up computed tomography of 53 TEVAR patients (36 ABD, 17 CBD) at a single institution between May 2005 and May 2016. The volumes of aortic lumen (AL), true lumen, false lumen (FL) and perfused FL were measured at the stent graft level (A), from the stent graft to the coeliac trunk (B) and from the coeliac trunk to the bifurcation (C). The absolute volumes, normalized volume changes and FL thrombosis rate of ABD and CBD patients were compared.RESULTSAbsolute AL and FL of segment A were significantly larger in CBD patients compared to ABD patients preoperatively (AL: 354 ± 68 vs 255 ± 51 ml, P = 0.023, FL: 253 ± 56 vs 183 ± 35 ml, P = 0.028) until last follow-up (AL: 462 ± 52 vs 246 ± 52 ml, P = 0.003, FL: 268 ± 202 vs 91 ± 31 ml, P = 0.004). The true lumen in segment A increased more in ABD than in CBD patients preoperatively to postoperatively (112% vs 36% P &lt; 0.001) and within the first year postoperatively (171% vs 80% P &lt; 0.001). FL in segment A decreased more in ABD compared to CBD patients within the first year (−42% vs −13% P &lt; 0.001) and thereafter (−50% vs +6% P = 0.002). In segments B and C, the FL thrombosis rate was higher in ABD than in CBD patients at all time points and significantly higher in segment A after the first year (91% vs 98% P = 0.035).CONCLUSIONSAortic remodelling after TEVAR is significantly different in acute and chronic dissection patients. TEVAR promotes aortic remodelling in both acute and chronic dissections in terms of true lumen increase at stent graft level. Nevertheless, significant AL reduction by FL shrinkage is primarily found in ABD.
The European Registry for Patients with Mechanical Circulatory Support (EUROMACS): second EUROMACS Paediatric (Paedi-EUROMACS) report
Authors: de By Theo M M H , Antonides Christiaan F J , Schweiger Martin , Sliwka Joanna , Davies Ben , Berger Felix , Hübler Michael , Özbaran Mustafa , Maruszewski Bohdan , Napoleone Carlo Pace , Zimpfer Daniel , Sandica Eugen , Antretter Herwig , Meyns Bart , Miera Oliver 
Published: March 2020

Abstract

OBJECTIVES
A second paediatric report has been generated from the European Registry for Patients with Mechanical Circulatory Support (EUROMACS). The purpose of EUROMACS, which is operated by the European Association for Cardio-Thoracic Surgery, is to gather data related to durable mechanical circulatory support for scientific purposes and to publish reports with respect to the course of mechanical circulatory support therapy. Since the first report issued, efforts to increase compliance and participation have been extended. Additionally, the data provided the opportunity to analyse patients of younger age and lower weight.

METHODS
Participating hospitals contributed pre-, peri- and long-term postoperative data on mechanical circulatory support implants to the registry. Data for all implants in paediatric patients (≤19 years of age) performed from 1 January 2000 to 1 July 2019 were analysed. This report includes updates of patient characteristics, implant frequency, outcome (including mortality rates, transplants and recovery rates) as well as adverse events including neurological dysfunction, device malfunction, major infection and bleeding.

RESULTS
Twenty-nine hospitals contributed 398 registered implants in 353 patients (150 female, 203 male) to the registry. The most frequent aetiology of heart failure was any form of cardiomyopathy (61%), followed by congenital heart disease and myocarditis (16.4% and 16.1%, respectively). Competing outcomes analysis revealed that a total of 80% survived to transplant or recovery or are ongoing; at the 2-year follow-up examination, 20% died while on support. At 12 months, 46.7% received transplants, 8.7% were weaned from their device and 18.5% died. The 3-month adverse events rate was 1.69 per patient-year for device malfunction including pump exchange, 0.48 for major bleeding, 0.64 for major infection and 0.78 for neurological events.

CONCLUSIONS
The overall survival rate was 81.5% at 12 months following ventricular assist device implant. The comparison of survival rates of the early and later eras shows no significant difference. A focus on specific subgroups showed that survival was less in patients of younger age (&lt;1 year of age) (P = 0.01) and lower weight (&lt;20 kg) (P = 0.015). Transplant rates at 6 months continue to be low (33.2%) The fact that the EUROMACS registry is embedded within the European Association for Cardio-Thoracic Surgery Quality Improvement Programme offers opportunities to focus on improving outcomes.
Knowledge, attitudes and practices of general medical practitioners in developed countries regarding oral cancer: an integrative review
Authors: Saraswat Nidhi , Everett Bronwyn , Pillay Rona , Prabhu Neeta , George Ajesh 
Published: March 2020

Abstract

Background
Oral cancer is a public health concern and is widespread in developing countries, particularly in South Asia. However, oral cancer cases are also rising in developed nations due to various factors, including smoking, viruses and increased migration from South Asia. In this context, the role of general medical practitioners (GPs) in identifying oral cancer is becoming increasingly important and, while some studies have explored their perspective about oral cancer, a synthesis of these results has not been undertaken.

Objective
The objective of this integrative review is to synthesize existing evidence regarding oral cancer-related knowledge, attitudes and practices of GPs in developed countries.

Methods
Four electronic databases were searched to identify studies focussing on the objective of this review. The inclusion criteria were: peer-reviewed English language publications; studies conducted in developed countries involving GPs; explored at least one study outcome (knowledge/attitudes/practices). No restrictions were placed on the publication date.

Results
A total of 21 studies involving 3409 GPs were reviewed. Most studies revealed limited knowledge of GPs about emerging risk factors, such as betel nut chewing (0.8–50%). Significant variation (7–70%) was evident in routine oral examination practices of GPs. Most GPs felt unsure about diagnosing oral cancer and many (38–94%) raised the need for further education. No study explored the specific relevance of GPs’ practices concerning South Asian immigrants.

Conclusion
This review suggests the need for educational programs to enhance GPs’ knowledge regarding oral cancer. Further research exploring oral cancer-related practices of GPs caring for South Asian immigrants is warranted.
Concomitant carriage of KPC-producing and non-KPC-producing Klebsiella pneumoniae ST512 within a single patient
Authors: Jousset Agnès B , Bonnin Rémy A , Takissian Julie , Girlich Delphine , Mihaila Liliana , Cabanel Nicolas , Dortet Laurent , Glaser Philippe , Naas Thierry 
Published: March 2020

Abstract

Background
KPC-producing Klebsiella pneumoniae of clonal group 258 are prominent in healthcare settings in many regions of the world. The blaKPC gene is mostly carried by a multireplicon IncFIIk-IncFI plasmid suspected to be highly compatible and stable in this genetic background. Here, we analysed the genetic diversity of an ST512 K. pneumoniae population in a single patient.

Methods
Twelve K. pneumoniae isolates (n = 5 from urine samples and n = 7 from rectal swabs) were recovered from one patient over a 2 month period. Antimicrobial susceptibility testing, plasmid extraction and WGS were performed on all isolates. The first K. pneumoniae isolate, D1, was used as a reference for phylogenetic analysis.

Results
Antimicrobial susceptibility testing, plasmid analysis and WGS revealed concomitant carriage of carbapenem-resistant and carbapenem-susceptible K. pneumoniae isolates of ST512, with the absence of the entire blaKPC-carrying plasmid in the susceptible population. Furthermore, 14 other genetic events occurred within the genome, including 3 chromosomal deletions (of 71 kb, 33 kb and 11 bp), 2 different insertions of ISKpn26 and 9 SNPs. Interestingly, most of the events occurred in the same chromosomal region that has been deleted independently several times, probably after homologous recombination involving 259 bp repeated sequences.

Conclusions
Our study revealed (to the best of our knowledge) the first case of in vivo blaKPC-carrying plasmid curing and a wide within-patient genetic diversity of a single K. pneumoniae ST512 clone over a short period of carriage. This within-patient diversity must be taken into account when characterizing transmission chains using WGS during nosocomial outbreaks.
Is it time for computable evidence synthesis?
Authors: Dunn Adam G , Bourgeois Florence T 
Published: March 2020

Abstract
Efforts aimed at increasing the pace of evidence synthesis have been primarily focused on the use of published articles, but these are a relatively delayed, incomplete, and at times biased source of study results data. Compared to those in bibliographic databases, structured results data available in trial registries may be more timely, complete, and accessible, but these data remain underutilized. Key advantages of using structured results data include the potential to automatically monitor the accumulation of relevant evidence and use it to signal when a systematic review requires updating, as well as to prospectively assign trials to already published reviews. Shifting focus to emerging sources of structured trial data may provide the impetus to build a more proactive and efficient system of continuous evidence surveillance.