bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of fluid responsiveness in mechanically ventilated patients in surgical intensive care unit by pleth variability index and inferior vena cava diameter
Authors: Aboelnile Diaaeldin Badr Metwally Kotb , Elseidy Mohamed Ismail Abdelfattah , Kenawey Yasir Ahmed Elbasiony Mohamed , Elsherif Ibrahim Mohammed Alsayed Ahmed 
Published: October 2020

Abstract
Background
Patients may have signs of hypovolemia, but fluid administration is not always beneficial. We are in need of bedside devices and techniques, which can predict fluid responsiveness effectively and safely. This study is aiming to compare the effectiveness and reliability of the pleth variability index (PVI) and IVC distensibility index (dIVC) as predictors of fluid responsiveness by simultaneous recordings in all sedated mechanically ventilated patients in the surgical intensive care unit (ICU). We used the passive leg raising test (PLR) as a harmless reversible technique for fluid challenge, and patients were considered responders if the cardiac index (CI) measured by transthoracic echocardiography (TTE) increased ≥ 15% after passive leg raising test (PLR).

Results
This observational cross-sectional study was performed randomly on 88 intubated ventilated sedated patients. Compared with CI measured by transthoracic echocardiography, the dIVC provided 79.17% sensitivity and 80% specificity at a threshold value of > 19.42% for fluid responsiveness prediction and was statistically significant (P < .0001), with an area under the curve (AUC) of 0.886 (0.801–0.944), while PVI at a threshold value of > 14% provided 93.75% sensitivity and 87.5% specificity and was statistically significant (P < .0001), with an AUC of 0.969 (0.889–0.988).

Conclusion
PVI and dIVC are effective non-invasive bedside methods for the assessment of fluid responsiveness in ICU for intubated ventilated sedated patients with sinus rhythm, but PVI has the advantage of being continuous, operator-independent, and more reliable than dIVC.
Chronic cannabis consumption and physical exercise performance in healthy adults: a systematic review
Authors: Kramer Andrew , Sinclair Justin , Sharpe Lara , Sarris Jerome 
Published: October 2020

Abstract
Objective
The effects of chronic cannabis consumption on physiological parameters of athletic performance are investigated to determine whether chronic cannabis consumption negatively affects athletic performance; improves performance, potentially via enhanced recovery; or has no effect at all.

Methods
A systematic review of the literature (cross-sectional, longitudinal, and intervention studies) concerning the effects of cannabis consumption on sports performance outcomes, e.g. VO2Max (maximal oxygen uptake), PWC (physical work capacity) up to January 2020 was conducted using the PubMed, CINAHL, Medline, PsycArticles, PsycInfo, SPORTDiscus, Psychology and Behavioural Sciences Collection, and Health Source: Nursing/Academic Edition databases. After screening and additional forward searching, four articles were found to fit the inclusion criteria.

Results
Resting heart rate was the only physiological measure that significantly differed between groups, and only in one of the four studies included herein. The strongest predictors of athletic performance (VO2Max and PWC) were not found to be significantly different between groups in any of the included studies. Chronic cannabis consumption had no significant effect on athletic performance. The included studies did not assess other elements, such as recovery or endurance.

Conclusion
No evidence exists for ergogenic or ergolytic effects from chronic cannabis consumption. In some sports, advantages may plausibly be conveyed by psychotropic enhancement or pain reduction. Further research (particularly longitudinal or interventional studies) is required to determine whether cannabis, or constituents thereof, may provide indirect supplemental benefits to athletes.
Development and evaluation of a digital, community-based intervention to reduce noncommunicable disease risk in a low-resource urban setting in Malaysia: a research protocol
Authors: Kataria Ishu , Ngongo Carrie , Lim Shiang Cheng , Kocher Erica , Kowal Paul , Chandran Arunah , Kual Aaron , Khaw Fu-Meng , Mustapha Feisul Idzwan 
Published: October 2020

Abstract
Background
Noncommunicable disease burden is rising in Malaysia, accounting for 72% of all deaths. Urbanization and globalization have contributed to changing patterns of diet and physical activity, creating an obesogenic environment that increases noncommunicable disease risk, especially in low-income populations. Community-based and technological interventions can play an important role in addressing structural determinants that influence noncommunicable disease burden. The Better Health Programme Malaysia aims to co-create and develop a community-based digital intervention for low-income populations to enable community stakeholders to address obesogenic environments and improve people’s knowledge, attitudes, and practices related to noncommunicable disease risk.

Methods
This quasi-experimental study will assess community member and community health volunteer knowledge, attitudes, and practices on noncommunicable disease prevention, risk factors, and health-seeking behavior in three geographical areas of Kuala Lumpur, each representing a different ethnicity (Malay, Indian, and Chinese). Assessment will take place before and after a 9-month intervention period, comparing intervention areas with matched control geographies. We plan to engage 2880 community members and 45 community health volunteers across the six geographic areas. A digital health needs assessment will inform modification of digital health tools to support project aims. Intervention co-creation will use a discrete choice experiment to identify community preferences among evidence-based intervention options, building from data collected on community knowledge, attitudes, and practices. Community health volunteers will work with local businesses and other stakeholders to effect change in obesogenic environments and NCD risk. The study has been approved by the Malaysian Ministry of Health Medical Research Ethical Committee.

Discussion
The Better Health Programme Malaysia anticipates a bottom-up approach that relies on community health volunteers collaborating with local businesses to implement activities that address obesogenic environments and improve community knowledge, attitudes, and practices related to NCD risk. The planned co-creation process will determine which interventions will be most locally relevant, feasible, and needed. The effort aims to empower community members and community health volunteers to drive change that improves their own health and wellbeing. The learnings can be useful nationally and sub-nationally in Malaysia, as well as across similar settings that are working with community stakeholders to reduce noncommunicable disease risk.

Trial registration
National Medical Research Register, Malaysia; NMRR-20-1004-54787 (IIR); July 7, 2020
Study Protocol: Understanding SARS-Cov-2 infection, immunity and its duration in care home residents and staff in England (VIVALDI)
Authors: Krutikov Maria , Palmer Tom , Donaldson Alasdair , Lorencatto Fabiana , Forbes Gill , Copas Andrew , Robson James , Hopkins Susan , Moss Paul , Farrar Jeremy , Hayward Andrew , Shallcross Laura 
Published: October 2020

Global infection and mortality rates from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are disproportionately high in certain populations, including the elderly. Care home residents are frequently exposed to infection due to contact with staff and other residents, and are highly susceptible to infection due to their age and co-morbidity. In England, official statistics suggest that at least 25% of all deaths in care home residents since the start of pandemic are linked to coronavirus disease 2019 (COVID-19), but limited testing for SARS-CoV-2 early in the pandemic means estimates of the true burden of disease are lacking. Additionally, little is known about patterns of transmission between care homes, the community and hospitals, or the relationship between infection and immunity in care home staff and residents. The VIVALDI study plans to address these questions. VIVALDI is a prospective cohort study aiming to recruit 6,500 staff and 5000 residents from 105 care homes across England. Successive rounds of testing for infection will be performed over a period of 12 months. Nasopharyngeal swabs will detect evidence of viral RNA and therefore active infection (accompanied by collection of data on symptoms), whereas blood tests will detect antibodies and evidence of cellular immunity to SARS-CoV-2. Whole genome sequencing of viral isolates to investigate pathways of transmission of infection is planned in collaboration with the COVID-19 Genomics UK Consortium. Qualitative interviews with care home staff will investigate the impact of the pandemic on ways of working and how test results influence infection control practices and behaviours. Data from residents and staff will be linked to national datasets on hospital admissions, antibody and PCR test results, mortality and care home characteristics. Data generated will support national public health efforts to prevent transmission of COVID-19 and protect care home staff and residents from infection. Protocol registration: ISRCTN14447421 05/06/2020
The safety and accuracy of robot-assisted pedicle screw internal fixation for spine disease
Authors: Li Weishang , Li Gaoyu , Chen Wenting , Cong Lin 
Published: October 2020

Aims The aim of this study was to systematically compare the safety and accuracy of robot-assisted (RA) technique with conventional freehand with/without fluoroscopy-assisted (CT) pedicle screw insertion for spine disease. Methods A systematic search was performed on PubMed, EMBASE, the Cochrane Library, MEDLINE, China National Knowledge Infrastructure (CNKI), and WANFANG for randomized controlled trials (RCTs) that investigated the safety and accuracy of RA compared with conventional freehand with/without fluoroscopy-assisted pedicle screw insertion for spine disease from 2012 to 2019. This meta-analysis used Mantel-Haenszel or inverse variance method with mixed-effects model for heterogeneity, calculating the odds ratio (OR), mean difference (MD), standardized mean difference (SMD), and 95% confidence intervals (CIs). The results of heterogeneity, subgroup analysis, and risk of bias were analyzed. Results Ten RCTs with 713 patients and 3,331 pedicle screws were included. Compared with CT, the accuracy rate of RA was superior in Grade A with statistical significance and Grade A + B without statistical significance. Compared with CT, the operating time of RA was longer. The difference between RA and CT was statistically significant in radiation dose. Proximal facet joint violation occurred less in RA than in CT. The postoperative Oswestry Disability Index (ODI) of RA was smaller than that of CT, and there were some interesting outcomes in our subgroup analysis. Conclusion RA technique could be viewed as an accurate and safe pedicle screw implantation method compared to CT. A robotic system equipped with optical intraoperative navigation is superior to CT in accuracy. RA pedicle screw insertion can improve accuracy and maintain stability for some challenging areas. Cite this article: Bone Joint Res 2020;9(10):653–666.
Competências Empreendedoras na Indústria Criativa: Meios e necessidades de Aprendizagem de Músicos
Authors: Reis Tatiane Brum de Oliveira , Klein Amarolinda Iara da Costa Zanela 
Published: October 2020

Objetivo: compreender como músicos aprendem e quais são as suas necessidades de aprendizagem de competências empreendedoras.Metodologia/abordagem: a pesquisa é qualitativa. Foram realizadas entrevistas semiestruturadas com 31 músicos independentes brasileiros. Os dados foram analisados via codificação aberta, com apoio do software NVIVO.Principais resultados: com relação ao aprendizado, os resultados indicam que a maioria dos músicos aprende melhor por meio da prática, busca informações e conteúdos no Youtube e tem dificuldades de concentração ao aprender. Quanto às necessidades de aprendizagem de competências empreendedoras, destacam-se as competências de gestão, especialmente gestão do tempo e organização.Contribuições teóricas/metodológicas: o artigo contribui com estudos sobre empreendedorismo na indústria criativa, com foco no campo da educação empreendedora no setor das artes, considerando a Teoria da Aprendizagem Experiencial (TAE) como lente teórica. Traz evidências sobre como a aprendizagem experiencial ocorre nesse contexto.Relevância/originalidade: este artigo traz evidências sobre o processo de aprendizagem de profissionais criativos (músicos) e revela as suas principais necessidades de desenvolvimento de competências empreendedoras. A pesquisa fornece informações relevantes para a elaboração de futuras propostas de capacitação desses profissionais.
Polymorphism of MC4R gene associated with feed intake, nutrient digestibility, ADG and FCR at post-weaning in Bligon goats
Authors: Latifah L. , Maharani D. , Kustantinah K. , Hartatik T. 
Published: October 2020

The melanocortin-4 receptor (MC4R) gene plays an important role in sympathetic nerve activity, as well as adrenal and thyroid function and mediates the effects of leptin on energy homeostasis. This study aimed to investigate the effect of the 642 bpMC4R gene on feed intake, nutrient digestibility, average daily gain (ADG),and feed conversion ratio (FCR)at post-weaned in Bligon goat. Forty-six Bligon were used for the blood sample collection, and genomic DNA was extracted using the Geneaid isolation kit. Feed intake data were collected on 46 Bligon goats kept on 2 different animal houses, including the laboratory’s farm of Faculty of Animal Science Universitas Gadjah Mada (FAS UGM) with n=23 and Banyusoco farm (n=23). Variables observed were feed intake, nutrient digestibility,ADG,and FCR. All samples were genotyped using the PCR-RFLP method with the KpnIenzyme. One SNP was located in the exonic region (g.1079C/T). The t-test analysis revealed a significant association between SNP g.1079C/T and the digestibility of dry matter (DM), organic matter (OM),and total digestible nutrient (TDN) of Bligon goats at 7 months of age kept on FAS UGM, as well as the digestibility of DM, crude protein (CP), nitrogen-free extract (NFE),and TDN of Bligon goats at 7 months of age kept on Banyusoco. In conclusion, it is possible to use SNP g.1079C/T for animal genotyping and asaMAS for nutrient digestibility in Bligon goats
Antioxidant activity and chemical characteristics in egg albumen fermented by lactid acid bacteria
Authors: Nahariah N. , Hikmah H. , Yuliati F.N. 
Published: October 2020

Research on fermentation time and the addition of milk powder to egg albumen is still limited. The purpose of this study was to determine the antioxidant activity and chemical characteristics of fermented egg albumen using different levels of full cream milk powder and different microbial fermentation times. This study used a completely randomized factorial pattern design, 4 x 5 treatments with 4 replications. Research materials include egg albumen, full cream milk powder and mixed Lactic Acid Bacteria (L. bulgaricus, L.achidopillus, and Streptococcus thermopillus). The research treatments were the addition of powdered milk in different level (%) including, 0, 2, 4 and 6. Fermentation times were 0, 12, 24, 36, and 48 h, respectively. The results showed that the addition of powdered milk in different level and fermentation time had no significant effect on the antioxidant activity. The addition of different-level powdered milk was not significant on the glucose content and total protein, but it was very significant (P<0.01) on water content. The fermentation time had a very significant effect (P<0.01) on glucose levels and total protein, but it had no significant effect on the water content of albumen fermentation. Antioxidant activity did not change during the fermentation time and the addition of different-level milk powder. The 24 h fermentation time could reduce the total protein and glucose levels of egg albumen. Adding 2% milk powder could reduce the water content of egg albumen fermentation.
A Framework of Nonequilibrium Statistical Mechanics. II. Coarse-Graining
Authors: Montefusco Alberto , Peletier Mark A. , Öttinger Hans Christian 
Published: October 2020

Abstract
For a given thermodynamic system, and a given choice of coarse-grained state variables, the knowledge of a force-flux constitutive law is the basis for any nonequilibrium modeling. In the first paper of this series we established how, by a generalization of the classical fluctuation-dissipation theorem (FDT), the structure of a constitutive law is directly related to the distribution of the fluctuations of the state variables. When these fluctuations can be expressed in terms of diffusion processes, one may use Green–Kubo-type coarse-graining schemes to find the constitutive laws. In this paper we propose a coarse-graining method that is valid when the fluctuations are described by means of general Markov processes, which include diffusions as a special case. We prove the success of the method by numerically computing the constitutive law for a simple chemical reaction

A
⇄
B

A\rightleftarrows B

. Furthermore, we show that, for such a system, one cannot find a consistent constitutive law by any Green–Kubo-like scheme.
Simultaneous improvement of mechanical and conductive properties of poly(amide-imide) composites using carbon nano-materials with different morphologies
Authors: Fang Yawen , Yu Huang , Wang Yanbin , Zhang Zhehao , Zhuang Changlong , Fang Gui , Luo Zhonglin , Zhang Bo , Wang Biaobing 
Published: October 2020

Abstract
Two conductive carbon materials, one with a beaded-like structure (carbon black, ECP) and another with tube-like structure (functionalized multi-walled carbon nanotubes, FMWCNTs), were added into a poly(amide-imide) (PAI) matrix. Combining the advantages of ECP (good compatibility) and FMWCNT (high conductivity), the conductivity was improved from 3.7 S m−1 for PAI/FMWCNT polymer composites to 100 S m−1 for PAI/FMWCNT/ECP ternary conductive polymer composites, much higher than that of the sum of PAI/ECP and PAI/FMWCNT. The tensile strength increased from 40 to 70 MPa. The improved conductive and mechanical properties were mainly due to much more intensive conductive network produced in the PAI/FMWCNT/ECP ternary composites, which is useful for electron flow and stress spread. The number of hydrogen bond was increased by adding ECP into PAI/FMWCNT binary composites, and played an important role in forming the unique morphology as evident by Fourier transform infrared spectrometry (FTIR) and X-ray diffraction (XRD) measurements. These conductive composites have potential for flexible electronic applications.
A rare case of fructose-1,6-bisphosphatase deficiency: a delayed diagnosis story
Authors: Ergoren Mahmut Cerkez , Tuncel Gulten , Sag Sebnem Ozemri , Temel Sehime Gulsun 
Published: October 2020

Abstract

Objectives
Fructose-1,6-bisphosphatase deficiency (FBPase deficiency, OMIM 229700) is an early-onset rare genetic disorder caused by mutations in the FBP1 gene.

Case presentation
Our patient was 17-years-old when she was diagnosed with the disease. Initial sequencing analysis with Ion Torrent technology failed to detect the gross deletion that covered complete exon 2 (c.-24-26_170 + 5192del) of FBP1 gene and caused the delay in diagnosis. Deletion was then detected when sequencing was performed in an Illumina MiSeq platform.

Conclusions
This case emphasizes the importance of sequencing data analysis for precise diagnosis of rare diseases and therapy planning.
Influence of varying magnetic field on nonlinear wave excitations in collisional quantum plasmas
Authors: Roy Debasish , Sahu Biswajit 
Published: October 2020

Abstract
The nonlinear wave excitations arising from the spatially varying magnetic field in the quantum plasma environment are investigated in the frame work of quantum hydrodynamic model. In the weakly nonlinear, dispersive and dissipative limit it is shown that the varying magnetic field and collision-induced excitations can be described by a modified form of Korteweg-de Vries–Burgers’ type model equation. It is found that the dissipation terms (Burgers’ and collisional term) arise due to spatially varying magnetic field and the ion-neutral collisions. The numerical solutions of this equation predict that the localized soliton solutions decay algebraically due to the combined effect of varying magnetic field and collision by radiating oscillatory pulses behind the propagating soliton.
Ethyl acetate extract from Cistus x incanus L. leaves enriched in myricetin and quercetin derivatives, inhibits inflammatory mediators and activates Nrf2/HO-1 pathway in LPS-stimulated RAW 264.7 macrophages
Authors: D’Ambrosio Mario , Bigagli Elisabetta , Cinci Lorenzo , Gori Antonella , Brunetti Cecilia , Ferrini Francesco , Luceri Cristina 
Published: October 2020

Abstract

Cistus x incanus L. is a Mediterranean evergreen shrub used in folk medicine for the treatment of inflammatory disorders but the underlying mechanisms are not fully understood. We therefore investigated the anti-inflammatory effects of an ethyl acetate fraction (EAF) from C. x incanus L. leaves on lipopolysaccharide (LPS) activated RAW 264.7 macrophages. HPLC analysis revealed myricetin and quercetin derivatives to be the major compounds in EAF; EAF up to 1 µM of total phenolic content, was not cytotoxic and inhibited the mRNA expression of interleukin-6 (IL-6) and cyclooxygenase-2 (COX-2) (p < 0.05) and the production of prostaglandins E2 (PGE2) (p < 0.05). Meanwhile, EAF triggered the mRNA expression of interleukin-10 (IL-10) and elicited the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2), as well as the expression of its main target gene, heme oxygenase-1 (HO-1) (p < 0.05). These data indicate that EAF attenuates experimental inflammation via the inhibition of proinflammatory mediators and at least in part, by the activation of Nrf2/HO-1 pathway. These effects are likely due to myricetin and quercetin derivatives but the role of other, less abundant components cannot be excluded. Further studies to confirm the relevance of our findings in animal models and to highlight the relative contribution of each component to the anti-inflammatory activity of EAF should be conducted.
Solubilization, Hansen solubility parameters and apparent thermodynamic parameters of Osimertinib in (propylene glycol + water) cosolvent mixtures
Authors: Shakeel Faiyaz , Anwer Md. Khalid , Haq Nazrul , Alsarra Ibrahim A. 
Published: October 2020

Abstract
The solubilization, Hansen solubility parameters (HSPs) and apparent thermodynamic parameters of a novel anticancer medicine osimertinib (OMT) in binary propylene glycol (P) + water (W) cosolvent mixtures were evaluated. The mole fraction solubility (x
e) of OMT in various (P + W) cosolvent mixtures including neat P and neat W was determined at T = 298.2–318.2 K and p = 0.1 MPa by applying a saturation shake flask method. HSPs of OMT, neat P, neat W and (P + W) cosolvent compositions free of OMT were also estimated. The x
e values of OMT were regressed with Van’t Hoff, modified Apelblat, Yalkowsky-Roseman, Jouyban-Acree and Jouyban-Acree-Van’t Hoff models with an average errors of <3.0 %. The highest and lowest x
e value of OMT was estimated in neat P (2.70 × 10−3 at T = 318.2 K) and neat W (1.81 × 10−5 at T = 298.2 K), respectively. Moreover, HSP of OMT was found to be closed with that of neat P. The solubility of OMT was found to be increased significantly with an increase in temperature and P mass fraction in all (P + W) cosolvent compositions including neat P and neat W. The results of activity coefficients suggested higher molecular interactions in OMT-P combination compared with OMT-W combination. The results of thermodynamic studies indicated an endothermic and entropy-driven dissolution of OMT in all (P + W) cosolvent compositions including neat P and neat W.