bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGEMBANGAN BAHAN AJAR TEORI BILANGAN BERBASIS MACROMEDIA FLASH
Authors: Ulum Ulum Fatmahanik 
Published: November 2020

Penelitian ini bertujuan untuk menghasilkan dan mengetahui kualitas bahan ajar teori bilangan berbasis macromedia flash serta untuk mengetahui respon mahasiswa terhadap bahn ajar yang telah dikembangkan. Bahan ajar ini disusun menggunakan program Macromedia Flash Professional 8. Model pengembangan dalam penelitian ini menggunakan model ADDIE (Analysis, Design, Development, Implementation and Evaluation) dalam menghasilkan produk. Hasil penilaian ahli materi menunjukkan bahwa bahan ajar teori bilangan berbasis macromedia flash yang telah dikembangkan mempunyai kualitas baik dengan diperoleh skor 80,63%. Sedangkan hasil penilaian ahli media menunjukkan bahwa bahan ajar teori bilangan berbasis macromedia flash mempunyai kualitas baik dengan diperoleh skor 84,17%. Sedangkan respon mahasiswa 52% menyatakan baik dan 40,06% mahasiswa menatakan sangat baik. Berdasarkan penilaian tersebut berarti bahan ajar teori bilangan berbasis macromedia flash layak digunakan sebagai sumber belajar mandiri dalam pembeljaran teori bilangan
The Very First Operation of a Progressive Vortex Pump String in a Production Well
Authors: Castellões Octavio Guilherme , Fraga Ricardo dos , Moraes Carlos Stênio , Assmann Benno Waldemar , Lima Fabio Soares , Geremia Silvino , Schröer Ismael Nicholas , Moura Greco Tusset 
Published: November 2020

AbstractThe aim of this paper is to present all relevant information regarding the very first operation of a Progressive Vortex Pump (PVP) string in a production well of a continuous steam injection stimulated field, located in the northeast part of Brazil. The string used had a configuration similar to a typical Progressive Cavity Pump (PCP), with the pump being driven around 1,100 rpm by an electric motor located at the wellhead, through a sucker rod string. The paper will address all relevant information gathered during field operation.The procedure consisted of running a complete PVP string in a production well from a continuous steam injection stimulated field, for a period of up to six months or until a failure happened. The operation was monitored with a SCADA system acquiring relevant data, like demanded amperage and power from the electric motor and estimated torque at which the sucker rods were subjected. Flow rate tests were performed monthly, with their results enabling the comparison of the pump's performance when pumping water only and production fluid. After the failure, the string was pulled out from the well to be subjected to a thorough analysis in order to determine the root cause.Running a sucker rod string at 1100 rpm, well beyond the 300 rpm – 400 rpm limit typically found in Progressive Cavity Pumps, showed to be very challenging. At first glance, the present system configuration, with a sucker rod string driven pump, may sound to be a cost effective approach, especially by avoiding the use of a submersible electric motor. With that in mind, the paper will also discuss potential areas to improve overall system lifetime.Originally, a Progressive Vortex Pump was designed for automotive application, to pump gas from a car's tank to the fuel injection system. Therefore, the system as described in this paper is the very first successful attempt to apply such technology in the oil and gas E&P industry.The aim of this paper is to present all relevant information regarding the very first operation of a Progressive Vortex Pump string in a production well of a continuous steam injection stimulated field, located in the northeast part of Brazil. The paper will address how to properly configure the variable speed drive, the rod string specification and the flow rate test results.
Surface Diagnostics and Analysis in Optimization Technologies for Sucker Rod Pump Lifted Oil and Gas Wells
Authors: Nickell Ian Alton 
Published: November 2020

Abstract
Sucker rod pumping is a common artificial lift method for oil and gas wells in the United States. For decades when using this method, well analysts and production engineers looked at surface and downhole dynamometer cards to diagnose various downhole and surface equipment issues. In more recent years, advantageous rod pump diagnostic software tools have helped train well analysts and production engineers in the analysis of downhole dynamometers cards using comprehensive libraries of known behavior. Unfortunately, the same libraries do not exist for surface dynamometer cards. Without these libraries, diagnostics are based solely on information captured in the downhole dynamometer card. While most data used for analytics and diagnostics can be found in the downhole dynamometer card, a more comprehensive analysis can be done by looking at both the downhole and surface dynamometer cards.
Recently, great strides have been made to analyze data and patterns not only found in downhole dynamometer cards, but also surface dynamometer cards. Dynamometer card analysis experts agree that in some cases pump tagging and shallow friction are more visible in the surface dynamometer card than the downhole dynamometer card. Based on these expert opinions, algorithms have been developed that leverage data science tools and statistical methods to better detect both shallow friction and pump tagging problems that are visible in the surface dynamometer card well before they can be seen in the downhole dynamometer card, especially for deep wells.
These new algorithms will be additional tools to help well analysts and production engineers more quickly and effectively analyze dynamometer cards and optimize production for the sucker rod pumping system. While current downhole analytical software does provide great benefits to users, adding additional algorithms will provide a more robust and effective dynamometer card analysis.
Degraded Image Enhancement Using Dual-Domain-Adaptive Wavelet and Improved Fuzzy Transform
Authors: Huo Yuehua , Fan Weiqiang , Li Xiaoyu 
Published: November 2020

Abstract
A novel enhancement algorithm of degraded image based on dual-domain-adaptive wavelet and improved fuzzy transform is proposed, aiming at the problem of surveillance videos degradation caused by complex lighting conditions underground. The dual-domain filtering (DDF) is used to decompose the image into low-frequency sub-image and high-frequency sub-images. The contrast limited adaptive histogram enhancement (CLAHE) is used to adjust the overall brightness and contrast of the low-frequency sub-image. Discrete wavelet transform (DWT) is used to obtain low frequency sub-band (LFS) and high frequency sub-band (HFS). The wavelet shrinkage threshold method based on Bayesian estimation is used to calculate the wavelet threshold corresponding to the HFS at different scales. A Garrate threshold function that introduces adaptive adjustment factor and enhancement coefficient is designed to adaptively de-noise and enhance the HFS coefficients corresponding to wavelet thresholds at different scales. Meanwhile, the gamma function is used to realize the correction of the LFS coefficients. The constructed PAL fuzzy enhancement operator is used to perform contrast enhancement and highlight area suppression on the reconstructed image to obtain an enhanced image. The proposed algorithm is evaluated by subjective vision and objective indicators. The experimental results show that the proposed algorithm can significantly improve the overall brightness and contrast of the original image, suppress noise of dust & spray, enhance the image details and improve the visual effect of the original image. Compared with the images enhanced by the STFE, GTFE, CLAHE, SSR, MSR, DGR, and MSWT algorithms, the comprehensive performance evaluation indicators of the images enhanced by the proposed algorithm are increased by 312.50%, 34.69%, 53.49%, 22.22%, 32.00%, 10.00%, 60.98%, 3.13%, respectively. At the same time, comprehensive performance evaluation indicator of the enhance image and the robustness is the best, which is more suitable for image enhancement in different mine environments.
Clinical Impact and Risk Factors of Nonsusceptibility to Third-Generation Cephalosporins Among Hospitalized Adults With Monomicrobial Enterobacteriaceae Bacteremia in Southern Taiwan: A Multicenter Study
Authors: Lin Tsao-Chin , Hung Yuan-Pin , Lee Ching-Chi , Lin Wei-Tang , Huang Li-Chen , Dai Wei , Kuo Chi-Shuang , Ko Wen-Chien , Huang Yeou-Lih 
Published: November 2020

Abstract
Background: Reducing effectiveness of broad-spectrum cephalosporins against Enterobacteriaceae infections has been recognized. This study aimed to investigate risk factors and clinical significance of third-generation cephalosporin nonsusceptibility (3GC-NS) among the cases of monomicrobial Enterobacteriaceae bacteremia (mEB) at regional or district hospitals.Methods: The study was conducted at three hospitals at southern Taiwan between Jan. 2017 and Oct. 2019. Only the first episode of mEB from each adult (aged ≥20 years) was included. The primary outcome was in-hospital crude mortality.Results: Overall there were 499 episodes of adults with mEB included, and their mean age was 74.5 years. Female predominated, accounting for 53% of all patients. Escherichia coli (62%) and Klebsiella pneumoniae (21%) were two major causative species. The overall mortality rate was 15% (73/499), and patients infected by 3GC-NS isolates (34%, 172/499) had a higher mortality rate than those by 3GC-susceptible isolates (66%, 327/499) (21% vs. 11%, P=0.005). By the multivariate analysis, 3GC-NS was the only independent prognostic determinant (adjusted odds ratio [AOR], 1.78; P=0.04). Of note, male (AOR 2.02, P=0.001), nosocomial-acquired bacteremia (AOR 2.77, P<0.001), and usage of nasogastric tube (AOR 2.01, P=0.002) were positively associated with 3GC-NS, but P. mirabilis bacteremia (AOR 0.28, P=0.01) and age (AOR 0.98, P=0.04) negatively with 3GC-NS.Conclusion: For adults with Enterobacteriaceae bacteremia, 3GC-NS signifies a significant prognostic impact. Efforts to rapid identification of such antimicrobial resistance profiles should be incorporated into antimicrobial stewardship programs to achieve favorable outcomes.
Awareness of the Basic Knowledge of Hand Hygiene in Chinese Medical Facilities: A Questionnaire-Based Survey
Authors: YANG Jing , LONG Li , FENG Shu , SUN Wei , GAO Lifang , YANG Yamin , LIU Jie , ZHOU Junqing , ZHANG Fuyu , TIAN Jie , GAO Bin 
Published: November 2020

Abstract
Background: Hand hygiene is a key measure for the prevention and control of healthcare-associated infection. We investigated the level of awareness of the basic concepts surrounding hand hygiene among healthcare staff in China in order to inform the development of future targeted hand hygiene promotion activities. Methods: A pre-tested questionnaire was used to obtain data from April to June 2018 in 30 provinces and municipalities in three regions of China. Ten single/multiple-choice questions investigated the level of awareness of the role of hands in germ transmission, the concept of hand hygiene, and the indications when it should be performed. Logistic analysis was performed to identify differences between regions, types of hospitals, healthcare staff categories, clinical departments and gender.Results: A total of 52,286 responses were received. Among these, 45,455 (86.94%) complete surveys were eligible to be included in the final analysis. The two highest correct response rates concerned the relationship between hand hygiene and healthcare-associated infection and the characteristics of microbiota and resident flora on hands (97.71% and 96.35%, respectively). These were followed by awareness of the World Health Organization’s “My 5 moments for hand hygiene” concept (91.61%), glove use (90.53%), hand hygiene materials (89.28%), characteristics of microbiota and transient flora on hands (84.60%), indications for hand hygiene and other aspects (71.00%), the basic concept of hand hygiene (65.20%), and the effectiveness of alcohol-based handrub on the hand microbiome (48.04%). The overall correct response rate was 26.53%. Eastern China demonstrated a better knowledge than other regions (adjusted odds ratio [aOR] 4.08; 95% CI 3.84–4.32). Respondents in primary care facilities had a higher correct response rate than other types of hospitals (aOR 2.33; 95% CI 2.05–2.66) and logistics staff had the highest correct response rate than other professional groups (aOR1.84; 95% CI 1.53–2.29). Among clinical departments, staff in the outpatient/emergency room had the highest rate of correct responses (aOR1.51; 95% 1.34-1.71).Conclusions: Large differences exist in the basic knowledge of hand hygiene across different regions in China. Knowledge levels need to be specifically strengthened among secondary care facilities, nurse professionals, gynaecology/obstetrics/paediatric departments and infection control units.
Asymptomatic Bacteriuria Bacterial Profile and Antibiotic Susceptibility Pattern Among Pregnant Women Attending Antenatal Care (Anc) Clinic of Assosa General Hospital, Benishangul Gumuz Region, Western Ethiopia
Authors: Tusuna Duresa Abu , Orjino Teferra Abula 
Published: November 2020

Abstract
Background: ASB is a common problem in pregnant women and about 40% of women with untreated asymptomatic bacteriuria during pregnancy develop pyelonephritis, which might lead to low birth weight, preterm, premature rupture of membranes and preterm labour. Therefore, this study aimed to assess the prevalence of asymptomatic bacteriuria, antimicrobial susceptibility pattern of the isolates among pregnant women attending antenatal care clinic of Assosa General Hospital, western Ethiopia.Methods: A facility-based cross sectional study was conducted from January to February 2019. Well-mixed and uncentrifuged urine specimens obtained from the pregnant women was directly inoculated on cystine lactose electrolyte deficient agar (CLED) (Oxoid, Ltd, England) media by streak plate method. Bacterial isolates were identified as per the standard bacteriological procedure using colony characteristics, gram-staining, and series of biochemical tests. Antimicrobial susceptibility test was carried out by Kirby- Bauer disk diffusion technique on Muller-Hinton agar medium and the diameter of zone of inhibition was interpreted according toClinical Laboratory Standard Institute (CLSI) guidelinesResult: The overall prevalence of ASB among pregnant women in this study was 14.85%.E. coli was the most predominant isolate (50 %,) followed by K. pneumoniae (16.7%,), S. aureus (14.3%), coagulase negative staphylococci (CONS) (11.9%), and group B streptococci (GBS) (7.1%).Gram-negative bacteria were highly resistant for tetracycline (96.4%), ampicillin .Gram-positive bacteria were 100% sensitive for ceftazidime. Conclusion: Significant bacteriuria was observed in asymptomatic pregnant women. Therefore, routine laboratory diagnosis of ASB in pregnant women and providing appropriate treatment should be needed to reduce its complications.
Network-based Transcriptome Analysis of Two Maize Genotypes Identified Pathways Associated With Differences in Salt Tolerance
Authors: Mohasseli Taher , Rahmani Razgar Seyed , Darvishzadeh Reza , Dezhsetan Sara , Marchal Kathleen 
Published: November 2020

Abstract
BackgroundA better understanding of the molecular effects of salinity stress is key to improving salt tolerance in Zea mays. In this study, we combined phenotyping with transcript profiling and network analysis to study genotype-specific differences in salt tolerance in Zea mays. ResultAn extensive phenotypic screening identified two genotypes with an extreme phenotypic difference in tolerance towards salt stress. RNA-seq analysis of the selected salt-tolerant (R9) and salt-sensitive (S46) genotype was performed to unveil the molecular mechanism underlying the difference in salt tolerance. GO enrichment and network analysis on the results of the expression analysis identified phosphorylation-dependent signaling processes, ion transportation, oxidation-reduction, glutathione and tryptophan metabolism as the main processes different between the selected tolerant and sensitive genotypes. Genes belonging to the subnetwork enriched for phosphorylation and kinase activity shared a common regulatory element in their promoter region, which matched the binding site of an Arabidopsis TF with known role in salt-stress response.ConclusionNetwork-based transcriptome analysis of two maize genotypes identified pathways associated with differences in genotype-specific salt tolerance and identified a link between transcriptional and posttranslational regulation of salt tolerance.
Quality of Life and its Associated Factors among People Living with HIV/AIDS in Southeast of Iran (2018-2019)
Authors: Malekmohammadi Neda , Rad Ali Ahmad Rafiee , Iranpour Abedin , Ghalekhani Nima , Shafie Mehdi , Zolala Farzaneh , Sharifi Hamid 
Published: November 2020

Abstract
Aim: This study aimed to evaluate the quality of life (QoL) and its associated factors among people living with HIV referring to two referral centers for HIV infected people in the southeast of Iran.Methods: Using a convenience sampling, 104 HIV-infected people were recruited. Data were collected using the HIV/AIDS-Targeted Quality of Life (HAT-QoL) instrument with 42 items divided into 9 fields: overall activity, sexual activity, disclosure worries, health worries, financial worries, HIV mastery, life satisfaction, and medication concerns and provider trust. The higher score indicated the higher QoL. Bivariable and multivariable linear regressions were performed to analysis the data.Results: The average QoL score was 52.5 (standard deviation [SD] 13.9) (range 0 to 100). In the multivariable regression model, those who experienced higher external stigma score (B= -1.9; 95% CI-2.6; -1.1) and higher internal stigma score (B=-1.1; 95%CI=-1.5; -0.6) and those who were emplyed (B=-5.9; 95% CI=-9.7; -2.1) reported lesser QoL. However, divorced or widowed people versus single people (B=6.9; 95% CI=0.7; 13.1) reported a higher QoL.Conclusions: Studying the QoL among HIV infected patients and its correlated factors and trying to improve that could reduce the problems of HIV infected patients. This study showed, QoL among this population is a multidimensional and several factors (internal and external stigma, job and marital status) could affect it.
Material Analysis for Therapeutic Insoles
Authors: Paul Sathish , Kumar David Prakash , Siva B 
Published: November 2020

Abstract
Background: Customized footwear with appropriate insole material for offloading is widely used for preventing ulceration indiabetic and leprosy affected patients.Methods: Finite element analysis was carried outon a 3 dimensionally modelledinsole. The insole was tested with the boundary condition of constant geometry, constant loading and varied material properties to identify the biomechanical behaviour of material.Results: The study demonstrates that Ethylene Vinyl Acetate and Micro Cellular Rubber reduce the elevated plantar pressure significantly in comparison to the other materials commonly used in fabricating foot orthosis.Conclusion: The comparison of the insole materials provides the health worker the required knowledge for selection of appropriate material for therapeutic insoles. The mechanical analysis of materials through the computer aided analysis would help therapeutic footwear designer to design, fabricate and use appropriate insoles.
Role of Glycine Receptor α3 in the Phosphorylation of Extracellular Signal-Regulated Kinase by Prostaglandin E2
Authors: Wang Hung-Chen , Cheng Kuang-I , Tseng Kuang-Yi , Kwan Aij-Lie , Chang Lin-Li 
Published: November 2020

Abstract
Background: Glycine receptors (GlyRs) play a key role in the processing of inflammatory pain. We used Adeno-associated virus (AAV) for GlyRα1/3 gene transfer in F11 neuron cells, and investigated the effects and roles of pAAV-GlyRα1/3 on cell cytotoxicity and the prostaglandin E2 (PGE2)-mediated inflammatory response. Methods: pAAV-GlyRα1 and pAAV-GlyRα3 recombinant vectors were constructed, and cell viability was measured following pAAV-GlyRα1/3 transfection. The activation of mitogen-activated protein kinase (MAPK) inflammatory signaling and neuronal injury marker activating transcription factor 3 (ATF-3) were evaluated by western blotting; the level of cytokine expression was measured by ELISA.Results: We found that pAAV/pAAV-GlyRα1/3 transfection slightly, but not significantly, increased cell viability and induced extracellular signal-regulated kinase (ERK1/2) phosphorylation and ATF-3 activation. However, the transfection reagent lipofectamine significantly increased cell death and induced ERK1/2 phosphorylation and ATF-3 activation. More importantly, the PGE2-induced ERK1/2 phosphorylation in F11 cells was repressed by the expression of pAAV-GlyRα3 and administration of an EP2 inhibitor (PF-04418948), GlyRαs antagonist (strychnine), and protein kinase C inhibitor (G06983).Conclusions: PGE2-induced ERK1/2 phosphorylation can be modulated by GlyRα3. In addition, no changes in the levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, or IL-6 of the F11 cells were observed 6 hours after lipopolysaccharide (LPS) or complete Freund's adjuvant (CFA) treatment. These data suggest that delivering pAAV-GlyRα3 into neuron cells should be safe for downregulating PGE2-induced ERK1/2 phosphorylation and inflammation.
Effects of Propofol and Ketamine on The Neural Oscillations in CA1 of Rat Intact Hippocampus
Authors: Yu Zhang , Chen Ping , Tu Zhi-yi , Liu Yi-heng , Wang Zhi-ru , Shen Feng-yan , Wang Ying-wei 
Published: November 2020

Abstract
In this study, in vitro intact hippocampal preparation model was utilized to observe the effects of propofol and ketamine on the neural oscillations in CA1 of rat hippocampus. The intact hippocampi were dissected from the brain tissues of rats aged 14-16 days postnatal. Local field potential (LFP) recordings were performed with propofol and ketamine bath application at different concentrations. The power spectrum intensity of LFP in all the frequency bands, including delta (1-4 Hz), theta (4-8 Hz), alpha (8-13 Hz), beta (13-30 Hz) and gamma (30-80 Hz), were inhibited in a concentrationdependent manner by both general anesthetics. In order to further investigate the underlying mechanisms, the major binding site of propofol and ketamine were blocked respectively by picrotoxin and (2R)-amino-5-phosphonopentanoate when bath applying the general anesthetics. It revealed that the inhibitory effect of propofol on hippocampal oscillations might be via γ-aminobutyric acid A receptor, while the inhibitory effect of ketamine might be unconcerned with N-methyl-D-aspartic acid receptor.