bluuebunny/crossref_metadata_2025_split huggingface dataset:
Percolation threshold of multiwall carbon nanotube-PVDF composite for electromagnetic wave propagation
Authors: Yahya Noorhana , Sikiru Surajudeen , Rostami Amir , Soleimani Hassan , Shafie A’fza , Alqasem Bilal , Qureishi Saima , Ganeson Menaka 
Published: June 2020

Abstract
Advanced physical properties of conductive polymers fibre composites have attracted the attention of material scientists. Here, we produced a polymer fibre composite with aligned multiwall carbon nanotube (MWCNT) of different weight fractions, ranging from 0.25 wt% to 1.5 wt%. At 1.5 wt% additive, a conductor-non-conductor transition occurs that is percolation threshold. This effect enhances the electrical conductivity of polymer composite from 0.050 S m−1 to 326.250 S m−1. Electrically conductor polymer composite will be highly preferred to fabricate radio frequency antennas, due to their unique physical and mechanical properties. We evaluated the performance of the polymer composite antenna and observed the percolation effect in electromagnetic wave propagation of the composite antenna. Far-field radiation of 1.5 wt% MWCNT-polymer antenna was 0.728 V m−1, whereas the maximum far-field result of the antennas made by lower MWCNT concentrations was 0.102 V m−1. Adopting the mechanical properties of PVDF composite, the composite-based RF antenna can be used in robust environments, such as high pressure high temperature oil reservoirs.
Review of rationale and progress toward targeting cyclin-dependent kinase 2 (CDK2) for male contraception†
Authors: Faber Erik B , Wang Nan , Georg Gunda I 
Published: June 2020

AbstractCyclin-dependent kinase 2 (CDK2) is a member of the larger cell cycle regulating CDK family of kinases, activated by binding partner cyclins as its name suggests. Despite its canonical role in mitosis, CDK2 knockout mice are viable but sterile, suggesting compensatory mechanisms for loss of CDK2 in mitosis but not meiosis. Here, we review the literature surrounding the role of CDK2 in meiosis, particularly a cyclin-independent role in complex with another activator, Speedy 1 (SPY1). From this evidence, we suggest that CDK2 could be a viable nonhormonal male contraceptive target. Finally, we review the literature of pertinent CDK2 inhibitors from the preclinical to clinical stages, mostly developed to treat various cancers. To date, there is no potent yet selective CDK2 inhibitor that could be repurposed as a contraceptive without appreciable off-target toxicity. To achieve selectivity for CDK2 over closely related kinases, developing compounds that bind outside the conserved adenosine triphosphate-binding site may be necessary.
Burns in the elderly: a nationwide study on management and clinical outcomes
Authors: Goei Harold , van Baar Margriet E , Dokter Jan , Vloemans J , Beerthuizen Gerard I J M , Middelkoop Esther , van der Vlies Kees H ,   the Dutch Burn Repository group
Published: June 2020

Abstract

Background
In modern-day burn care, advanced age remains an important predictor for mortality among burn victims. In this study, we compared the complete treatment trajectory (including pre-hospital and surgical treatment) and the outcomes between an elderly burn population and a younger adult burn population.

Methods
In this nationwide study, data from the Dutch Burn Repository were used. This is a uniform national registration for Dutch specialized burn care. All adult patients that were admitted to one of the three Dutch burn centres from the period 2009 to 2015 were included in the analysis. Burn patients were considered as elderly when ≥65 years of age, and were then further subdivided into three age categories: 65–74, 75–85 and 85+ years. Younger adults in the age category 18–64 years were used as the reference group.
Surgical management was studied comprehensively and included timing of surgery, the number of procedures and details on the surgical technique, especially the technique used for debridement and the grafting technique that was applied.
For the comparison of clinical outcome, the following parameters were included: mortality, wound infections, length of stay/TBSA (total body surface area) burned, discharge disposition and secondary reconstructions.

Results
During the study period, 3155 adult patients were included (elderly, n = 505). Burn severity, reflected by the median TBSA, varied between 3.2–4.0% and was comparable, but aetiology and pre-hospital care were different between elderly and the younger adult reference group.
Surgical treatment was initiated significantly faster in elderly burn patients (p &lt; 0.001). Less selective techniques for surgical debridement were used in the elderly burns patients (hydrosurgery, 42.0% vs 23.5–22.6%), and on the other hand more avulsion (5.3% vs 7.3–17.6%) and primary wound closure (6.7% vs 24.5%). The most frequently used grafting technique was meshed skin grafts (79.2–88.6%); this was not related to age.
Mortality increased rapidly with a higher age and showed a high peak in the 85+ category (23.8%). Furthermore, considerable differences were found in hospital discharge disposition between the elderly and the reference group.

Conclusions
In conclusion, elderly burn patients who require specialized burn care are vulnerable and medically challenging. Differences in aetiology, comorbidity, physiology and the management prior to admission possibly affect the initial surgical management and result in significantly worse outcomes in elderly. Elderly patients need optimal, timely and specialized burn care to enhance survival after burn injuries.
The Enigma of the Human Immunodeficiency Virus (HIV) Epidemic in China
Authors: Wu Zunyou , McGoogan Jennifer M , Detels Roger 
Published: June 2020

Abstract
Nearly 17 years ago China launched its National HIV/AIDS Response Program, yet the epidemic still is not slowing. New cases and new deaths increase every year—in 2005, 40 711 people living with human immunodeficiency virus (HIV; PLWH) were diagnosed and 5729 died, whereas in 2019, 148 598 PLWH were diagnosed and 31 522 died. Moreover, the estimated PLWH population in China has risen to &gt;1.25 million. However, epidemic data are worryingly complex and difficult to interpret, presenting challenges to the redirection and refocusing of efforts toward achievement of control. Here we present three “windows” into China’s epidemic data. From these viewpoints, it appears we still do not know how much infection exists, how much transmission is occurring, and in what contexts transmission happens. The enigma that is China’s HIV epidemic must be better understood. A new research agenda must be developed and executed if we are to change the future of HIV in China.
Effects of canagliflozin on serum potassium in the CANagliflozin cardioVascular Assessment Study (CANVAS) Program
Authors: Weir Matthew R , Slee April , Sun Tao , Balis Dainius , Oh Richard , de Zeeuw Dick , Perkovic Vlado 
Published: June 2020

Abstract

Background
The sodium-glucose cotransporter 2 inhibitor canagliflozin has been shown to reduce the risk of cardiovascular and renal events in patients with Type 2 diabetes mellitus and high risk. Pooled analyses of data from early studies and interim data from the CANagliflozin cardioVascular Assessment Study (CANVAS) suggested that canagliflozin might lead to increases in serum potassium, particularly the 300 mg dose in patients with renal impairment, which is important because high serum potassium is associated with increased cardiovascular and renal risk. We examined the effect of canagliflozin on serum potassium levels and hyperkalemia rates in the completed CANVAS Program.

Methods
The CANVAS Program (n = 10,142) was comprised of two comparable double-blind, randomized, placebo-controlled trials (CANVAS and CANVAS-Renal). Participants received canagliflozin 100 or 300 mg or placebo. Serum potassium measurements were performed in a central laboratory0 and assessed at ∼6-month intervals.

Results
In the CANVAS Program, mean potassium levels were generally consistent with canagliflozin and placebo, overall and by baseline estimated glomerular filtration rate (eGFR; ≥60, 45 to&lt;60 and &lt;45 mL/min/1.73 m2). The risk of increased or decreased potassium was similar with canagliflozin and placebo overall and by baseline eGFR (all P-heterogeneity ≥0.56) or use of renin–angiotensin–aldosterone system inhibitors (all P-heterogeneity ≥0.71); levels did not appear different by canagliflozin dose. Hyperkalemia {hazard ratio (HR) [95% confidence interval (CI)] 1.60 (0.92–2.81)} and serious hyperkalemia [HR (95% CI) 0.75 (0.27–2.11)] adverse events were not different across groups.

Conclusions
In the CANVAS Program, there were no meaningful effects of canagliflozin on serum potassium in the overall population or key subgroups. Hyperkalemia adverse events were uncommon and occurred at comparable rates with canagliflozin and placebo.
Regulation of urinary calcium excretion by vasopressin
Authors: Anastasio Pietro , Trepiccione Francesco , De Santo Natale Gaspare , Capasso Giovambattista , Viggiano Davide , Capolongo Giovanna 
Published: June 2020

AbstractBackgroundThe antidiuretic hormone (ADH) or arginine vasopressin (AVP) regulates the body's water balance. Recently, modifications in AVP levels have been related to osteoporosis during ageing and microgravity/bed rest. Therefore the present study was devised to assess whether the absence of AVP, as in patients with central diabetes insipidus (CDI), modulates renal calcium excretion.MethodsWe retrospectively analysed data from 12 patients with CDI with measured 24-h urinary excretion levels of calcium. Data were available at the moment of the diagnosis when patients were drug-free and after therapy with dDAVP, an analog of AVP. Hypercalciuria was defined as 24-h urinary Ca2+ &gt;275 mg/day in males and &gt;250 mg/day in females and a urinary calcium (Ca):creatinine (Cr) ratio &gt;0.20 mg/mg.ResultsUntreated CDI patients had a daily urinary Ca2+ excretion of 383 ± 47 mg/day and a urinary Ca:Cr ratio of 0.26 ± 0.38 mg/mg. The urine osmolarity significantly increased after the administration of dDAVP by 210% and the urinary flow decreased by 72%. Furthermore, the estimated glomerular filtration rate (eGFR) increased by 7%, which did not reach statistical significance. dDAVP treatment did not significantly modify the urinary Ca2+ concentration; however, the daily calcium excretion and the urinary Ca:Cr ratio were significantly decreased (160 ± 27 mg/day and 0.11 ± 0.02 mg/mg, respectively).ConclusionsPatients with CDI show hypercalciuria even though urine is more diluted than normal controls, and dDAVP reverses this effect. These data support the intriguing relationship between AVP and osteoporosis in ageing and microgravity/bed rest.
Development and validation of protein biomarkers of health in grizzly bears
Authors: Wilson Abbey E , Michaud Sarah A , Jackson Angela M , Stenhouse Gordon , Coops Nicholas C , Janz David M 
Published: June 2020

Abstract
Large carnivores play critical roles in the maintenance and function of natural ecosystems; however, the populations of many of these species are in decline across the globe. Therefore, there is an urgent need to develop novel techniques that can be used as sensitive conservation tools to detect new threats to the health of individual animals well in advance of population-level effects. Our study aimed to determine the expression of proteins related to energetics, reproduction and stress in the skin of grizzly bears (Ursus arctos) using a liquid chromatography and multiple reaction monitoring mass spectrometry assay. We hypothesized that a suite of target proteins could be measured using this technique and that the expression of these proteins would be associated with biological (sex, age, sample location on body) and environmental (geographic area, season, sample year) variables. Small skin biopsies were collected from free-ranging grizzly bears in Alberta, Canada, from 2013 to 2019 (n = 136 samples from 111 individuals). Over 700 proteins were detected in the skin of grizzly bears, 19 of which were chosen as targets because of their established roles in physiological function. Generalized linear mixed model analysis was used for each target protein. Results indicate that sample year influenced the majority of proteins, suggesting that physiological changes may be driven in part by responses to changes in the environment. Season influenced the expression of proteins related to energetics, reproduction and stress, all of which were lower during fall compared to early spring. The expression of proteins related to energetics and stress varied by geographic area, while the majority of proteins that were affected by biological attributes (age class, sex and age class by sex interaction) were related to reproduction and stress. This study provides a novel method by which scientists and managers can further assess and monitor physiological function in wildlife.
Pollination Bag Type Has a Significant Impact on Cone Survival in Mass Production of Controlled Pollinated Seeds in Loblolly Pine
Authors: Heine Austin J , Walker Trevor D , McKeand Steven E , Jett Jackson B , Isik Fikret 
Published: June 2020

Abstract
Since 2009, deployment of full-sib families of loblolly pine (Pinus taeda L.) has gained prominence in the southeastern United States. To produce full-sib seed, a pollination bag is used to isolate female strobili from outside pollen contamination, and a known pollen is applied at the time of maximum female strobilus receptivity. The goal of this study was to compare prototype pollination bags made by PBS International to the industry standard kraft paper pollination bag with and without a support wire for female strobili survival and to assess their efficiency for mass production of controlled cross loblolly pine seed. A multiyear study compared 13 pollination bag types at more than nine seed orchard sites across the southeastern United States. There were significant differences among bag types for conelet survival at the time of bag removal that persisted until cone harvest 18 months later. Female strobili bagged in prototype PBS-I2 were over three times more likely to survive to cone harvest than strobili inside the traditional kraft pollination bag. Two of the PBS bag types had the highest estimated filled seed per bag. One PBS bag was faster to install and remove than the kraft paper bag with a support wire.
An improved pig reference genome sequence to enable pig genetics and genomics research
Authors: Warr Amanda , Affara Nabeel , Aken Bronwen , Beiki Hamid , Bickhart Derek M , Billis Konstantinos , Chow William , Eory Lel , Finlayson Heather A , Flicek Paul , Girón Carlos G , Griffin Darren K , Hall Richard , Hannum Greg , Hourlier Thibaut , Howe Kerstin , Hume David A , Izuogu Osagie , Kim Kristi , Koren Sergey , Liu Haibou , Manchanda Nancy , Martin Fergal J , Nonneman Dan J , O'Connor Rebecca E , Phillippy Adam M , Rohrer Gary A , Rosen Benjamin D , Rund Laurie A , Sargent Carole A , Schook Lawrence B , Schroeder Steven G , Schwartz Ariel S , Skinner Ben M , Talbot Richard , Tseng Elizabeth , Tuggle Christopher K , Watson Mick , Smith Timothy P L , Archibald Alan L 
Published: June 2020

Abstract

Background
The domestic pig (Sus scrofa) is important both as a food source and as a biomedical model given its similarity in size, anatomy, physiology, metabolism, pathology, and pharmacology to humans. The draft reference genome (Sscrofa10.2) of a purebred Duroc female pig established using older clone-based sequencing methods was incomplete, and unresolved redundancies, short-range order and orientation errors, and associated misassembled genes limited its utility.

Results
We present 2 annotated highly contiguous chromosome-level genome assemblies created with more recent long-read technologies and a whole-genome shotgun strategy, 1 for the same Duroc female (Sscrofa11.1) and 1 for an outbred, composite-breed male (USMARCv1.0). Both assemblies are of substantially higher (&gt;90-fold) continuity and accuracy than Sscrofa10.2.

Conclusions
These highly contiguous assemblies plus annotation of a further 11 short-read assemblies provide an unprecedented view of the genetic make-up of this important agricultural and biomedical model species. We propose that the improved Duroc assembly (Sscrofa11.1) become the reference genome for genomic research in pigs.
Accelerated loss of hypoxia response in zebrafish with familial Alzheimer’s disease-like mutation of presenilin 1
Authors: Newman Morgan , Nik Hani Moussavi , Sutherland Greg T , Hin Nhi , Kim Woojin S , Halliday Glenda M , Jayadev Suman , Smith Carole , Laird Angela S , Lucas Caitlin W , Kittipassorn Thaksaon , Peet Dan J , Lardelli Michael 
Published: June 2020

AbstractAgeing is the major risk factor for Alzheimer’s disease (AD), a condition involving brain hypoxia. The majority of early-onset familial AD (EOfAD) cases involve dominant mutations in the gene PSEN1. PSEN1 null mutations do not cause EOfAD. We exploited putative hypomorphic and EOfAD-like mutations in the zebrafish psen1 gene to explore the effects of age and genotype on brain responses to acute hypoxia. Both mutations accelerate age-dependent changes in hypoxia-sensitive gene expression supporting that ageing is necessary, but insufficient, for AD occurrence. Curiously, the responses to acute hypoxia become inverted in extremely aged fish. This is associated with an apparent inability to upregulate glycolysis. Wild-type PSEN1 allele expression is reduced in post-mortem brains of human EOfAD mutation carriers (and extremely aged fish), possibly contributing to EOfAD pathogenesis. We also observed that age-dependent loss of HIF1 stabilization under hypoxia is a phenomenon conserved across vertebrate classes.
Prosthesis-patient mismatch after surgical aortic valve replacement in patients with aortic stenosis
Authors: Kim Hee Jung , Kim Ho Jin , Kim Joon Bum , Jung Sung-Ho , Choo Suk Jung , Chung Cheol Hyun , Lee Jae Won 
Published: June 2020

Abstract

OBJECTIVES
The issue of prosthesis-patient mismatch (PPM) after surgical aortic valve replacement (SAVR) has been a controversial topic. We sought to evaluate the long-term clinical impacts of PPM in patients undergoing SAVR in an updated, homogeneous cohort.

METHODS
Using the prospective institutional database, we identified 895 adult patients (median age 66, interquartile range 58–72; 45.6% women) who underwent isolated SAVR from January 2000 to March 2016. Those with pure aortic insufficiency and concomitant other cardiac operations were excluded from this study cohort. The presence of a significant PPM was defined as an indexed effective orifice area 0.85 cm2/m2 or less. The outcome of interest was all-cause deaths. Propensity score matching was performed for adjusting bias.

RESULTS
Significant PPM was present in 247 patients (27.6%). During the follow-up period (mean 71.2 ± 51.04 months), 134 patients (15%) died. Survival rates at 10 and 15 years were 78.3% vs 83.8% and 71.3% vs 57.6% in the PPM and non-PPM groups (P = 0.972). Risk factor analysis indicated that developing PPM was not associated with a risk of death. After propensity score matching (1:1), developing PPM was not a risk factor for long-term death as well (P = 0.584).

CONCLUSIONS
Significant PPM was common after SAVR in patients with aortic stenosis. However, there was no significant difference in survival rate between those with and without PPM.
Stall Wars: When Do States Fight to Hold onto the Status Quo?*
Authors: Spaniel William , Bils Peter , Judd Gleason 
Published: June 2020

Abstract
In many wars, fighting allows states to hold onto some of the disputed good until the conflict is over. Indeed, war may look attractive to some actors for that purpose even if they will likely lose and incur substantial costs in the process. How does this incentive to stall alter the likelihood of conflict onset? We develop a model in which a delay exists between war’s initiation and termination. During that time, states maintain a division of the disputed good. If states value the future at different rates, no mutually preferable settlement may exist. War is more likely when a more patient state is powerful but holds a smaller share during the dispute. In addition, we show that the parameters for war are non-monotonic in the length of conflict: fighting only occurs when the delay falls in a middle range.
Uncovering the early history of the Georgia Museum of Natural History, 1785–1900
Authors: McPherson Megan , Freeman Byron J , Pilaar Birch Suzanne E 
Published: June 2020

Abstract
Although it holds one of the largest university-based natural history collections in the United States, little has been known historically about the early development of the Georgia Museum of Natural History at the University of Georgia in Athens. Formally established in 1978, it was recognized as the state museum of natural history in 1999, but the findings presented here reveal that the origins of the museum’s collections date to much earlier: the early 1800s. Research conducted at the Richard B. Russell Special Collections Library tells the previously unknown story of the museum’s founding and growth during the nineteenth century. This paper details key aspects of the development of the collection, its changing location on campus, and the museum’s relationship with the university’s library and botanical gardens; it also identifies researchers in charge of the collections in the early and pivotal years of the institution.
Increased Responses of Phenoloxidase in Chlorantraniliprole Resistance of Plutella xylostella (Lepidoptera: Plutellidae)
Authors: Wang Nian-Meng , Li Jing-Jing , Shang Ze-Yu , Yu Qi-Tong , Xue Chao-Bin 
Published: June 2020

Abstract
The diamondback moth (Plutella xylostella, DBM) is an important pest of cruciferous vegetables. The use of chlorantraniliprole has been essential in the management of the DBM. However, in many countries and areas, DBM has become highly resistant to chlorantraniliprole. Three different DBM strains, susceptible (S), chlorantraniliprole-selected (Rc), and field-collected (Rb) resistant strains/populations were studied for the role of phenoloxidase in resistance development to the insecticide. By assaying the activity of phenoloxidase (PO) in the three different DBM strains, the results showed that the PO activity in the Rc strain was increased significantly compared with the S strain. The synergistic effects of quercetin showed that the resistant ratio (RR) of the QRc larvae to chlorantraniliprole was decreased from 423.95 to 316.42-fold compared with the Rc larvae. Further studies demonstrated that the transcriptional and translational expression levels of PxPPO1 (P. xylostella prophenoloxidase-1 gene) and PxPPO2 (P. xylostella prophenoloxidase-2 gene) were increased to varying degrees compared with the S strain, such as the transcriptional expression levels of PxPPO2 were 24.02-fold that of the S strain. The responses of phenoloxidase were significantly different in chlorantraniliprole-resistant DBM.
Do Accidental Wars Happen? Evidence from America's Indian Wars
Authors: Szarejko Andrew A 
Published: June 2020

Abstract
The question of whether war can ever truly be accidental has been the subject of much academic debate. To provide my own answer to this question, I use an oft-ignored part of US history—the so-called Indian Wars between Native nations and an expanding United States. Specifically, this research innovation makes use of three militarized conflicts of the nineteenth century—the Black Hawk War (1832), the Cayuse War (1847–1855), and the Hualapai War (1865–1870)—to provide evidence that war can indeed occur accidentally. I conclude that IR scholars should be less confident in asserting that accidental war does not happen and that this possibility counsels restraint for policy-makers, especially in emerging domains of conflict.