bluuebunny/crossref_metadata_2025_split huggingface dataset:
Similarity Measurement of the Geometry Variation Sequence of Intermediate Process Model
Authors: Li Chunlei , Li Liang , Wang Xiaoye 
Published: May 2020

Abstract
The reuse of machining process, by which the process for a new mechanical part is determined by referencing to the existing and matured processes, is an effective way of improving manufacturing and supporting innovation. To conduct the effective reuse it is necessary to express and retrieve a specific process. A kernel technique of the expression and the retrieval is to measure the similarity of part’s geometry variation during the machining. To address this problem, a general framework of measuring the similarity between parts is proposed in this work. The geometry variation sequence of intermediate process model is established, and then a method to measure its similarity is invented. Two case studies are rendered and the result reveals that the proposed method is effective and can provide the support for the process retrieval and reuse in industry.
MWCNTs - Ni-Cu NPs @ a-C:H thin films: Study of relation between the average diameters of CNTs with optical density and topological characterizations
Authors: Goudarzi Samira , Dalouji Vali 
Published: May 2020

Abstract
In this paper, Ni-Cu NPs @ a-C:H thin films with different content of cooper by co-deposition of RF-sputtering and RF-plasma enhanced chemical vapor deposition (RF-PECVD) were prepared from acetylene gas and Ni and Cu targets. The prepared samples as catalysts for growing multi-wall carbon nanotubes (MWCNTs) were used from liquid petroleum gas (LPG) by thermal chemical vapor deposition (TCVD) at 825 °C. The films deposited with 5% Cu have minimum value the average diameter of CNTs and were about 100 nm. The fractal dimensions and structural characteristics as well as optical density of Ni-Cu NPs thin films have been investigated. AFM images can estimate the lateral size of the nanoparticles on the films surface. These values for Ni NPs without Cu NPs @ a-C:H thin film and with Cu NPs thin film contenting 5%, 40%, 75% Cu are obtained about 7.2, 5.34, 6.04 and 11.16 nm respectively. The optical density (Dopt) of thin films was obtained from the relation Dopt =

\alpha
t. Films deposited with 75% Cu have maximum value of optical density specially in high energy. The spectral density power of all layers reflects the reverse flow changes,, especially in the high spatial frequency region, indicating the presence of fractal components in prominent topographies. Films deposited with 75% Cu have minimum value of fractal dimension. The diagram of the Bearing Area proportion the height shows the percentage of cavities and single-layers. It can be seen that the single-layer content of all films were about 95%.
Facile synthesis of Rh/Ti3+-TiO2 nanocomposites and its photodisinfection properties on Staphylococcus aureus under visible-NIR excitation
Authors: Zhang Jingtao , Liu Shurui , Wang Qinwen , Yao Jing , Liu Yin , Liu Bingkun , xiao jun , Shi Hengzhen 
Published: May 2020

Abstract
In this study, we synthesized a series of rhodium-modified and Ti3+ self-doped TiO2 (Rh/Ti3+-TiO2) nanocomposites via the one-pot method. We prepared samples of Rh/Ti3+-TiO2, which were analyzed using X-ray diffraction (XRD), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), Electron Spin Resonance (ESR), and Uv-vis-NIR analysis. We found that the ability of TiO2 to absorb near-infrared and visible light was significantly improved by the Rh/Ti3+-TiO2 nanocomposites, due to Ti3+ doping as well as modification of Rh. The disinfection properties of these materials were tested using Staphylococcus aureus under visible light and NIR light excitations. The synthesized photocatalyst was found to exhibit significantly enhanced photocatalytic inactivation of S. aureus under both visible and NIR light irradiation, as compared to pure TiO2. This was particularly true with respect to the 5% Rh/Ti3+-TiO2 sample. Our results suggest that the Rh/Ti3+-TiO2 composites could extend the range of optical response range of pure nano TiO2 materials to the Vis -NIR region.
Utility of FebriDx in early identification of possible COVID19 infection
Authors: Karim Nawazish , Ashraf Muhammad Zubair , Naeem Muhammad , Anwar Tahir , Aung Hnin , Mallik Srikumar , Avraam Eleni , Kiran Sidra , Bandapaati Sareesh , Khan Faisal , Tsaknis Georgios , Reddy Raja V. 
Published: May 2020

Abstract
Background Reliable differentiation between uncomplicated and self-limiting acute respiratory tract infections (ARIs) and more severe bacterial respiratory tract infections remains challenging, due to the non-specific clinical manifestations in both systemic bacterial or viral infections. The current COVID-19 pandemic is putting extraordinary strain on healthcare resources. To date, molecular testing is available but has a long turnaround time and therefore cannot provide results at the point-of-care, leading to a delay in results thereby exposing patients to cross-infection and delay in diagnosis (1-3). Methods We prospectively evaluated the utility of FebriDx®, a point-of-care fingerstick blood test that can differentiate viral from bacterial ARIs through simultaneous detection of both Myxovirus-resistance protein A (MxA) and C-reactive protein (CRP), in rapidly determining viral cases requiring immediate isolation and confirmatory molecular testing, from non-infectious patients or bacterial infections that require antibacterial therapy.Results 75 consecutive patients were assessed and 48 eligible cases were tested with FebriDx®. Overall, 35 patients had FebriDx® test viral positive. All 35 patients had either positive rt-PCR (n=30) for COVID-19 or clinical picture highly suggestive of COVID-19 infection (PPV of 100% in a pandemic situation)[AB1] . In the 13 cases it was viral negative, rRT-PCR was also negative in all cases. In one case of LRTI, it was not possible to determine the exact cause of infection and a viral infection couldn’t be excluded. Including this patient, the NPV was 12/13 (92%) exceeding the NPV of rRt-PCR at 71% (12/17). Sensitivity was conservatively calculated at 97% (35/36) compared to 85.7% (30[RS2] /35) for rRt-PCR. Similarly the specificity of both FebriDx®and rRt-PCR was 100% (12/12).Conclusions In the current COVID-19, FebriDx® shows potential as a reliable POC test and a proxy marker of COVID-19 infection amongst inpatients in a secondary care setting. [AB1]35/35 equates to a sensitivity and specificity of 100% for COVID, would you be willing to say that instead of ‘near 100% ppv)? [RS2]I believe PCR was 85.7% (30/35), because PCR only detects the COVID cases
Fruit ripening-associated leucylaminopeptidase with cysteinylglycine dipeptidase activity from durian suggests its involvement in glutathione recycling
Authors: Panpetch Pawinee , Sirikantaramas Supaart 
Published: May 2020

Abstract
BackgroundDurian (Durio zibethinus M.) is a highly popular fruit in Thailand and several other Southeast Asian countries. It is abundant in essential nutrients and several sulphur-containing compounds such as glutathione (GSH) and γ-glutamylcysteine (γ-EC). Cysteinylglycine (Cys-Gly) generated by GSH catabolism is also found in durian fruit pulp. Cysteine (Cys) is a precursor of the sulphur-containing volatiles produced during durian fruit ripening and accounting for the strong odour and flavour of the ripe fruit. However, the genes encoding plant Cys-Gly dipeptidases have seldom been identified. Our aim was to analyse the Cys-Gly peptidase activity of leucylaminopeptidase (LAP) in durian fruit pulp. ResultsDzLAP1 and DzLAP2 were identified, which the former was highly expressed in the fruit pulp. DzLAP1 expression at various ripening stages and in response to ethephon/1-MCP treatments suggested that DzLAP1 is active and important at the early stages of fruit ripening. Biochemical characterisation showed that DzLAP1 is a metalloenzyme activated by Mg2+ or Mn2+, is approximately 63 kDa in size, and has an optimal alkaline pH of 9.5 which is typical of LAPs. Kinetic studies revealed that DzLAP1 had a Km of 1.62 mM for its preferred substrate Cys-Gly. DzLAP1-GFP was localised to the cytosol and targeted to the plastids. ConclusionsDzLAP1 has Cys-Gly dipeptidase activity in the γ-glutamyl cycle. The present study discloses that the LAPs identified in durian fruit pulp are implicated in the high sulphur-containing compound levels observed at full ripening.
Changes in body composition with a hypocaloric high-protein diet combined with sedentary, moderate and high-intense physical activity in overweight or obese males: a 6-month randomized controlled trial
Authors: Hernández-Reyes Alberto , Vidal A. , Cámara-Martos F. , Molina-Luque R. , Moreno-Rojas R. 
Published: May 2020

Abstract
Objectives

Although the effectiveness of high-intensity training has been widely recognized as positive in athletes, its application in a clinical context is not well established. There is enough evidence to confirm that high-intensity routines are safe and that at-risk populations, such as for overweight and obese subjects, can help from these weight loss treatments. The purpose of this study was to lead a trial to test whether manipulation of physical activity in extension to high protein diet intake would induce changes in total weight and body composition.
Methods

Sixty-eight healthy male volunteers were randomly assigned to one of the experimental groups: a control group with a low-level prescription of physical activity (1–4 METs), moderate physical activity group that performed 10.000 steps walking per day (5–8 METs) and intense physical activity group that trained exercises by at least 70% of VO2max three times a week (> 8 METs). All subjects followed a high-protein diet designed with a reduction of 500 kcal/day. Nutritional counseling was provided throughout the study period to help ensure dietary adherence. This intervention was delivered over twenty-four sessions as weekly one-on-one, face-to-face 30-min consultations.
Results

A significant reduction in body fat percentage was observed in the intense physical activity group (-20.9 ± 8.8 (CI95%: -25.6 – -16.2), p < 0.001). The change in muscle mass did not produce any significant differences between groups (p > 0.05). Concerning weight, a notable weight loss was found in those subjects who performed moderate or intense physical exercise, vs. those who did light exercise, (p < 0.001) and (p < 0.003), respectively.
Conclusion

our data strongly suggest that resistance training should be included, whenever possible, in any dietary treatment for improving the body composition of men with overweight or obesity.
Evaluation of the environmental impact of two types of food in intensive farming of rainbow trout fry (Onchoryncus mykiss. Walbaum, 1792).
Authors: abba El Hassan , Dahak Oumaima , Ainane Tarik , Yaacoubi Adnane El 
Published: May 2020

Abstract
The environmental impact of two types of food distributed during the first phase of intensive breeding of rainbow trout (Oncorhynchus mykiss) fry at the station of the National Center for Hydrobiology and Pisciculture constitutes the main objective of this study. the method used for the evaluation of the impact of these two foods is the mass balance method based on the calculation of the quantities of nitrogen and phosphorus excreted according to the quantities of food ingested and the composition of the carcasses. The results obtained show that the weight growth of fry and the rate of nitrogen and phosphorus rejection during the experimental period are very different and vary depending on the type of food received.
Inhibiting CBX4 efficiently suppress YAP nucleus translocation in hepatocellular carcinoma cells to protect against sorafenib resistance
Authors: zhao wei , Ma BO , Tian Zhihua , Han Haibo , Tang Jintian , Dong Bin , An Guo , Cao Baoshan , Wang Boqing 
Published: May 2020

Abstract
Background

The discovery of biomarkers that predict the response to sorafenib and increase the efficiency of drug therapy represents a clinical challenge. This study aimed to investigate the possible role of inhibiting CBX4 to deregulate of CSCs and to evaluate the contribution of these molecules to sorafenib resistance in advanced HCC.
Methods

HCC cell lines and a xenograft mouse model with resistance to sorafenib were employed to analyze the effects of miR424 on CSC characteristics. RNA expression was analyzed by RT-PCR and next-generation sequencing in a cohort of 106 HCC cancer patients and sorafenib-resistant (SR) cell lines, respectively, to validate the key microRNAs and targets in the network. CBX4 expression was determined in HCC cells to examine YAP1-mediated stem-cell-like activation and its association with sorafenib resistance.
Results

MicroRNA and mRNA profiles of SR cell lines identified miR424 and its direct target CBX4 as significantly associated with stem-cell-like properties, poor survival and clinical characteristics. Functional experiments demonstrated that miR424 suppressed CBX4, and CBX4 induced nuclear translocation of YAP protein but was not associated with protein production. When YAP1 and CBX4 were modulated either alone or together in SR tumors with CA3 and UNC3866, respectively, tumorigenicity and stem-like properties were extremely inhibited, thus indicated that these compounds exerted a strong antitumor effect in vivo against SR HCC cells.
Conclusions

Our results revealed that blocking the crosstalk between CBX4 and YAP1 is critical in response to sorafenib resistance, and it could be a promising therapeutic strategy for patients with advanced HCC.
Comparison of the effect of the graft with double strands peroneus longus tendon and with the four strands hamstring tendon on reconstruction of the posterior cruciate ligament injury
Authors: Lu Yue , Xu Hua , Zhou Zhenyu , Fang Lei , Tao Ran 
Published: May 2020

Abstract
Background

This prospective study was to analyze the clinical effect of double-stranded long peroneal tendon and the four strands hamstring tendon in reconstruction of posterior cruciate ligament (PCL), and to investigate the effectiveness and safety of the two surgical approaches in reconstruction of PCL, so as to provide guidance for clinical treatment of PCL injury.
Methods

Total 48 patients with complete rupture of PCL treated in our hospital from July 2015 to February 2017 were selected and divided into the Group A (reconstructed with double strands peroneus longus tendon, 25 cases) and the Group B (four strands hamstring tendon, 23 cases) according to the different grafts.
Results

The intraoperative time for tendon extraction in the Group A (20.87 ± 2.07 min) was significantly shorter than that in the Group B (26.79 ± 2.32 min). Compared with pre-operation, the tibial posterior displacement of the two groups decreased significantly 24 months after operation, and IKDC score, Lysholm score and Tegner score increased significantly. Nevertheless, the IKDC score, Lysholm score, Tegner score, AOFAS score and Maryland score between the two groups before and after operation were no significant differences. Compared with the quadrupled hamstring tendon, the double-stranded peroneal longus tendon has the advantages of simple and safe tendon extraction.
Conclusions

Both surgical methods are effective for the treatment of PCL injury. When the four strands hamstring tendon is accidental (tendon rupture or tendon variation) or ineffective, the peroneal longus tendon will be a good choice.
Do standard neurological assessments tell us more than we realise?
Authors: Donnan Luke , Baker Emma , Horn Anna , Robinson Caroline 
Published: May 2020

Abstract
Background Neurological assessments are commonly performed by podiatrists as a screening tool for peripheral neuropathy, and to identify the risk of foot ulceration and amputation. Monofilament and tuning fork assessments are routinely used to assess peripheral sensation. Whilst these assessments are commonly used to monitor foot health, there is potential for neurological results to illuminate a broader and more holistic perspective of a person’s overall health status. Methods Recruitment of fifty participants (31 female, 19 male; 71.78±9.64 years) for foot health screening was associated with a foot health week promotional event at the Charles Sturt University Community Engagement and Wellness Centre. Under the guidance of registered podiatrists, fourth year podiatry students completed basic neurological assessments to determine each participant’s neurological status. Participants also completed a modified Foot Health Status Questionnaire (FHSQ). Age and monofilament results were analysed using Spearman’s rho, while correlations involving FHSQ data were identified using a Kruskal-Wallis test. Results For those participants who reported an excellent rating of their own health, there was a statistically significant relationship with adequate vibration sensation (p<0.01). A person’s ability to get up from a sitting position (p<0.01), lift and carry shopping (p=0.02) and climb a flight of stairs (p=0.03), was significantly correlated with more sites detected using monofilament assessment. Discussion Significant correlations were observed between basic neurological assessments and a number of activities of daily living. While the findings reflect a correlational relationship, not causational, this still provides an opportunity for clinicians to view neurological assessment results more holistically. Whilst the immediate focus for a practitioner will be tissue viability, neurological findings may be useful to stimulate further discussion about a patient’s functional capacity by exploring issues beyond the presenting condition.
Barriers and facilitators to implementing Clinical Imaging Referral Guidelines among medical professionals: Protocol for a systematic mixed studies review
Authors: Kisembo Harriet Nalubega , Kinengyere Alison Annet , Sahal Abdirahaman Omar , Malumba Richard , Salaama Dina Husseiny , Kawooya Michael Grace 
Published: May 2020

Abstract
Background The past two decades have seen increasingly rapid advances in the field of diagnostic imaging technology. This has significantly contributed to the quality of medical care outcomes. However, a number of studies have found that 20%-50% of imaging requisitions are inappropriate and unjustified. This wastes the already meager resources and exposes patients to unnecessary radiation with increased risk of radiation induced cancers.Clinical Imaging Guidelines (CIGs) are evidence-based tools developed to support the imaging referrer’s decision-making process by choosing the most appropriate imaging investigation for a particular patient with a specific set of symptoms and signs. However, implementing CIGs has not been effective in several settings. Identifying factors that influence CIGs implementation could give an insight into the type of strategies to put in place before implementing CIGs This systematic review protocol is aimed at understanding barriers and facilitators that influence implementation of CIGs among medical professions. Review Methods The development of the systematic review protocol will follow Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA-P) (additional file 1) Key databases Pubmed (Medline) and Embase will be searched using relevant terms. The, experts in the field will be contacted for their opinion and references from included studies will also be searched Only literature written in the English language will be reviewed. All study designs will be included, and there will be no limit set by the year of publication. The criteria for inclusion will be those studies which document and discuss barriers and facilitators to implementing CIGs among medical professions. All identified studies will be screened by a single reviewer but Quality of the studies to be included and extraction of data will be independently performed by two reviewers. Any discrepancies will be resolved by consensus through discussion, with a 3rd reviewer as a tie breaker Pre-established categories of barriers and facilitators to implementing CIGs in practice from literature, will be used to assess content analysis Discussion The findings from this review will provide an insight and direction to the “champions” implementing adoption or adaption of CIGs, especially in Africa of what is ahead of them for proper planning The protocol has been registered at the International Prospective Register of Systematic Reviews (PROSPERO; registration number: CRD42020136372.
Comprehensive evaluation of risk factors for lymph node metastasis with papillary thyroid carcinoma in Southwest China patients
Authors: Dong Yan , Wang Dan , Luo Yisheng , Chen Ling , Bai Huili , Shen Yifan , Zhang Yangli , Chen Xueping , Su Xinliang , Zhao Jinqiu , Liu Huandong , Lu Jungao , Yao Zuoyi , Zhao Yajing , He Changlong , Li Xiaosong 
Published: May 2020

Abstract
Background: With the increasing incidences of papillary thyroid cancer(PTC), it is important to risk-stratify patients who may have more aggressive tumor biology. This study aimed to evaluate the risk factors for lymph node metastasis with PTC in Southwest China Patients which may provide a substantial reference for clinical diagnosis and treatment. Methods: 1045 PTCs (313 PTMC and 732 non-PTMC) between August 2016 and August 2019 were examined totally (including one Tibetan). BRAF V600E mutation was tested in all samples. The clinical data (gender, age, tumor location, sample source and pathological features) were retrospectively analyzed. Logistic regression analysis was performed to evaluate independent risk factors for LNM. Results: 181 out of 313 PTMC cases (57.8%), 145 out of 732 non-PTMC cases (19.8%) had BRAF V600E mutation, the Tibetan had a double mutation of BRAF L597Q and V600E in two separate lesions. In PTMC, significant difference in gender and sample source was found (BRAF V600E mutation vs. wild-type). In non-PTMC, significant difference in gender was found (BRAF V600E mutation vs. wild-type). The female (OR=1.952; 95% CI= 1.373-2.774; P= 0.00), age (31-59 years) and diameter of tumor ≤1cm (OR=3.273; 95% CI= 2.417-4.432; P=0.000) were significant independent predictors of LNM in all PTCs. In PTMC, the female (OR= 3.002; 95% CI= 1.654-5.446; P= 0.00) was a significant independent predictor of LNM. The tumor in left and right lobes simultaneously was an independent protective factor of LNM in each group (PTCs: OR=0.287; PTMC: OR=0.170; non-PTMC: OR=0.441, respectively). The BRAF V600E mutation rate of US-FNAC was much higher than FFPE in PTMC (P=0.018). Conclusions: Unlike previous research, our findings suggested that the female patients and diameter of tumor ≤1cm were risk factors for LNM and the BRAF V600E wild-type of PTMC might be more aggressive than others. Interestingly, the position of tumor in bilateral thyroid simultaneously was an independent protective factor for LNM. The US-FNA should be recommended for gene analysis (BRAF V600E) in PTMC. The BRAF L597Q mutation may be an independent aggressive factor in the Chinese Tibetan population. Hence, clinicians should consider an individualized treatment according to gene mutation, gender, age, tumor size and location of tumor in order to achieve a better therapeutic efficacy.