bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison with Tube Core and Magill forceps for Nasotracheal Intubation: A Randomized Controlled Trial
Authors: Hu Rui , Niu Jingyi , Wu Lining , Sun Hao , Sun Peng , Huang Jiaying , Yu Junma 
Published: October 2020

Abstract
Background: Magill forceps are frequently used to complete the process of nasotracheal intubation (NTI). We aimed to identify a tube core that could facilitate the NTI process conveniently without Magill forceps. Methods: Sixty patients with no differences between the two groups (30 per group) with regard to demographic data were enrolled in our study. In Group M, the wire-reinforced tracheal tube was inserted into the trachea using Magill forceps. However, in Group T, a tube core bent to the physiological curve of the nasal cavity lubricated with aseptic liquid paraffin was inserted into the tracheal tube, and the tube core was then withdrawn after the tracheal tube was advanced through the glottis under direct vision. Results: All NTIs were completed successfully, and no Magill forceps were used in Group T. There was a significant difference in total NTI time between the two groups (Group M, 59.7 (5.1) sec vs Group T, 52.4 (3.1) sec). Mild epistaxis was observed in 6 patients in Group M and 5 patients in Group T (6/30 vs 5/30, respectively). There was no presence of damaged oral tissue or damage to the teeth in either group. Conclusion: We conclude that using the tube core, which is a disposable sterilised stylet, for NTI is a convenient choice. Trial registrations: This clinical research was registered at the Chinese Clinical Trial Registry (www.Chictr.org.cn, ChiCTR1900027387).
Oncologic Outcomes of ypT1-3N0&nbsp;mid-Low Rectal Cancer Compared&nbsp;with pT1-3N0 Disease After Radical Resection
Authors: Yang Hong , Di Jiabo , Cui Ming , Xing Jiadi , Zhang Chenghai , Yao Zhendan , Zhang Nan , Liu Maoxing , Xu Kai , Tan Fei , Su Xiangqian 
Published: October 2020

Abstract
Background: Neoadjuvant chemoradiotherapy (CRT) can downstage rectal carcinoma, resulting in superior resectability, better local control and survival benefits. However, it is unclear whether patients treated with CRT and those who did not have similar outcomes at the same pathological stage. This study aimed to investigate the long-term outcomes of ypT1-3N0 mid-low rectal cancer who received neoadjuvant CRT followed by total mesorectal excision (TME) compared with pT1-3N0 rectal cancer immediately managed with surgery. Methods: We retrospectively enrolled 180 patients with pT1-3N0 or ypT1-3N0 rectal cancer located within 10cm from the anal edge who underwent TME between 2009 and 2015. Of these patients, 63 received neoadjuvant CRT, while 117 underwent radical proctectomy without preoperative therapy. The disease-free survival (DFS) and cancer-specific survival (CSS) were compared between the two groups. Results: Within a median follow-up time of 65 months, the 5-year DFS was lower in the CRT group than the non-CRT group (74.9% vs. 92.6%, P=0.001), and the 5-year CSS presented a similar trend as well (89.6 % vs. 97.1%, P=0.054). By subgroup analysis, the difference in DFS and CSS was mainly caused by the difference between ypT3N0 and pT3N0 disease (71.1% vs. 96.1%, P＜0.001 and 90.9% vs. 100%, P=0.029, respectively). However, patients with ypT1-2N0 had an analogous prognosis to those with pT1-2N0 disease (77.9% vs. 89.0%, P=0.225 and 88.1% vs. 94.2%, P=0.292, respectively). Multivariate analysis indicated that neoadjuvant CRT was not an independent predictor of DFS. Conclusion: After neoadjuvant CRT followed by TME, patients with ypT1-2N0 rectal cancer had an analogous prognosis to those with initial pT1-2N0 disease, whereas patients with ypT3N0 rectal cancer had worse prognosis compared with that of pT3N0 disease.
Physicochemical Properties of Shea Butter Synthesized Biodiesel
Authors: OKOYE IFEANYI GODWIN , EZEONU CHUKWUMA STEPHEN , DANLAMI ELIZABETH KIGBU 
Published: October 2020

Abstract
Base – catalyzed transesterification of Shea (Vitellaria paradoxa) seed fat was carried out at a methanol/oil ratio of 5:1 (V/V) at 70oC to synthesize the corresponding methyl esters (biodiesel). The percentage yield of approximately 87%, was recorded after ninety minutes, indicating that Shea fat is a good biodiesel feedstock. The physicochemical properties of the Shea biodiesel were determined. The colour was pale yellow while the relative density (870 Kg/m3), kinematic viscosity (2.66 mm2s-1 400C), acid value (0.19 mg KOH/g), peroxide value (0.52 meq/kg) and cetane number (68.10) were observed. The cloud point was found to be 9.30C, while the flash point of 156.670C, iodine value of 35.29 mg/100g and energy value of 39.3 MJ/Kg were recorded. All these value compare well with previous works and are within acceptable limits as specified by the American Society for Testing and Materials (ASTM). The current research indicated that Shea butter has biodiesel potential aside its uses in culinary and cosmetics applications.
REaCH-Resiliency Engagement and Care in Health; A Telephone Befriending Intervention to Address The Psycho-Social Challenges of Vulnerable Population in The Context of COVID-19 Pandemic: An Exploratory Trial in India
Authors: Saju M D , Scaria Lorane , Shaju KK , Cheguvera Natania , Joseph MK , Benny Anuja Maria , Joseph Binoy 
Published: October 2020

Abstract
Background Observational evidence suggests that befriending interventions provided by the lay mental health workers, when trained and supervised by experts, are effective in enhancing social support, wellbeing and reducing depression. We carried out a telephone intervention for youth, recruited from DDUGKY (Deen Dayal Upadhyaya Grameen Kaushalya Yojana), a central government funded skill development project in India.Methods We performed an exploratory trial in Kerala, India, between 29th July, 2020 and 26th August, 2020 with pass out students of DDUGKY. From a total of 1036 students, 498 fulfilled the criteria and were recruited for the program. We randomized the participants via a computer generated randomization list. Out of 498 eligible participants, 251 were randomized to the intervention group and 247 to the general enquiry call group. Total of 439 (89%) participants, (251 (100%) = intervention arm and 188 (76%) = control arm), completed follow-up assessment after one month. The primary outcomes of the study included depression, measured by Patient Health Questionnaire (PHQ-9) and wellbeing, using WHO Wellbeing Index; while secondary outcomes included social support from friends and family.Results Analysis was done for 439 pass out students who completed one-month intervention. Befriending intervention was effective in increasing the wellbeing (p=0.000) and social support (p=0.008) in the intervention group. Regression analysis revealed that befriending intervention is associated with notable changes in support from significant others (OR: 2.91, P=0.005), support from family (OR: 2.47, P=0.013) and support from friends (OR: 2.52, P=0.007).Conclusion Befriending intervention was found successful in improving overall wellbeing and social support among student participants of the programme. Large-scale transformational efforts to secure country’s mental health service pipeline is possible by integrating this intervention into existing DDU-GKY institutional and program eco-systems. Task shifting and sharing strategies can be effectively employed to improve the mental health outcomes of the people especially during a community crisis. Trial Registration Clinical Trial Registry India; ICMR-NIMS (Registration Number: CTRI/2020/07/026834), prospectively registered (Registration date: 27th July 2020) , http://ctri.nic.in/Clinicaltrials/showallp.php?mid1=45953&EncHid=&userName=CTRI/2020/07/026834
Evaluation of Helminth Infections Identified in Slaughtered Livestock in Iran, 2015-2019
Authors: Kiani Behzad , Budke Christine M. , Abadi Ebrahim Shams , Hashtarkhani Soheil , Rahmati Amene Raouf , Akbarpour Mostafa , Zarean Mehdi , Hosseini Bibi Razieh Farash , Kiani Fatemeh , Moghaddas Elham 
Published: October 2020

Abstract
Introduction: Helminth infections of livestock can result in considerable economic losses. This study aims to evaluate the spatial frequency of cystic echinococcosis (CE), dicrocoeliasis, and fascioliasis in livestock slaughtered in Iran during the years 2015-2019 and estimate direct costs associated with organ condemnation due to these parasites.Methods: Abattoir data from all 31 Iranian provinces were collected from the Iran Veterinary Organization. Infection prevalence was calculated per year at the province level. The Local Moran's I statistic was performed to evaluate spatial autocorrelation of animals positive at slaughter for the years 2015-2019. Direct costs associated with condemned livers were calculated for each parasitic condition. Results: Overall prevalence values for the study timeframe were as follows: sheep and goat fascioliasis (1.5%, 910,282/58,393,349), cattle fascioliasis (3.8%, 23,3175/6,038,419), sheep and goat dicrocoeliasis (4.6%; 270,1274/58,393,349), cattle dicrocoeliasis (3.1%; 186,009/6,038,419), sheep and goat CE (5.3%; 3,108,767/58,393,349), and cattle CE (7.2%; 438,534/6,038,419). Northwestern Iran had the highest prevalence of CE and fascioliasis. High infection areas for Dicrocoelium spp. included the provinces of Zanjan, Gilan, Qazvin, and Tehran, which are located in northern Iran. Direct economic losses for sheep and goat fascioliasis, dicrocoeliasis, and CE for the study period were US$13,841,826, US$41,768,472, and US$22,801,296, respectively. Direct economic losses for cattle fascioliasis, dicrocoeliasis, and CE for the study period were US$1,989,582, US$1,669,289, and US$2,656,535, respectively.Conclusion: Our findings provide valuable data for future monitoring of these important parasitic diseases in Iranian livestock. Disease control strategies are required to reduce the economic and public health impact of these helminths.
Association of Metabolic Syndrome and Cardiovascular Risk Factors Among Colorectal Cancer Patients Attending in Tikur Anbessa Specialized Hospital Oncology Units: A Comparative Cross-sectional Study June, 2017 Addis Ababa, Ethiopia
Authors: Elemo Shimelis Adugna , Awoke Bereket Mihretu 
Published: October 2020

Abstract
Background: Metabolic syndrome and obesity are risk factors for developing type 2 diabetes mellitus and/or cardiovascular disease, especially stroke. Obesity-associated diseases account for a large portion of public health challenges. Among obesity-related disorders, a direct and independent relationship has been ascertained for colorectal cancer. Objective: The aim of this study was to determine the prevalence of metabolic syndrome and other cardiovascular risk factors, including dyslipidemia, hypertension, dietary and exercise practices, tobacco use and body mass index in individual with colorectal cancer patients attending Tikur Anbessa Hospital Oncology department, Addis Ababa.Methods: A comparative cross-sectional study was conducted from February, 2016 to Jun 2017 on 79 patients attending the Oncology clinic at Tikur Anbessa Hospital. Components of metabolic syndrome, including fasting serum glucose, serum triglyceride, serum high density lipoprotein, blood pressure and waist circumference, was measured in all of the patients. In addition, serum total cholesterol, serum low density lipoprotein was measured with 5010 photometers, and information gathered on smoking and other lifestyle practices, including diet and exercise.Result: Of 79 patients, 23 had metabolic syndrome (MS); 58.2% males; mean-age 48.6 years with range (26 to 78) and 41.8 % Female; mean age 44.6 years with range (20 to 78). Among the MS group, 45.6 % had high blood pressure, 26.6 % had increased waist circumference, 67.1% had serum blood glucose level greater than 100 mg/dL, 68.3 % had low high-density lipoprotein cholesterol level, 57 % had increased triglyceride level, and 3.8 % were obese [body mass index (BMI) >30 kg/m2]. 29 % presented 3 criteria of MS. From total colorectal cancer patients 53.2 % had colon cancer, 46.8 % had rectal cancer and 12.7 % had stage I,40.5 % had stage II (IIa,IIb & IIc), 25.3 % had stage III (a,b,c) and 21.5 % had stage IV disease.CONCLUSION: MS is positively associated with adenomas and colorectal cancer. However, there is not enough information in Ethiopia to justify screening in patients with MS. To our knowledge, no previous study has evaluated this association in Ethiopian patients.
Combining Targeted Metabolite Analyses and Transcriptomics to Reveal Specific Chemical Composition and Associated Genes in Resistant Soybean Infected with Soybean Cyst Nematode
Authors: Shi Xue , Chen Qiansi , Liu Shiming , Wang Jiajun , Peng Deliang , Kong Lingan 
Published: October 2020

Abstract
Background: Soybean cyst nematode Heterodera glycines is one of the most devastating pathogens on soybean and causes severe annual yield loss worldwide. Different soybean varieties exhibit different responses to soybean cyst nematode infection at various levels, such as genomic, transcriptional, proteomic, and metabolomic levels. However, there were not yet any reports on the differential responses of resistant and susceptible soybeans infected with soybean cyst nematode by combining the metabolomic analyses and transcriptomics.Results: In this study, a highly-resistant variety PI 437654 and three susceptible varieties Williams 82, Zhonghuang 13 and Hefeng 47 were used as the test materials to clarify the differences in metabolites and transcriptomics between resistant and susceptible soybeans before and after SCN infection. A local metabolite-calibrated database was used to identify potential differential metabolites, and the differences of metabolites and metabolic pathways were compared between the resistant and susceptible soybean varieties after inoculation with SCN. Totally, 37 differential metabolites and 20 KEGG metabolic pathways were identified, which were divided into three categories including the metabolites/pathways overlapped among resistant and susceptible soybeans, specific in susceptible or resistant soybeans, respectively. Twelve differential metabolites were found to be involved in predicted KEGG metabolite pathways. Moreover, 14 specifically differential metabolites such as significantly up-regulated nicotine and down-regulated D-aspartic acid, and their involved KEGG pathways such as tropane, piperidine and pyridine alkaloid biosynthesis, alanine, aspartate and glutamate metabolisms, sphingolipid metabolism and arginine biosynthesis were significantly changed and abundantly enriched in the resistant soybean, and likely played pivotal roles in defensing against SCN infection. Three key metabolites including N-acetyltranexamic acid, nicotine, and D, L-typotophan, which were found to be significantly up-regulated in the resistant soybean PI437654 infected by SCN, classified into two types and used for combination analyses with the transcriptomic expression profiling. Associated genes were predicted, and suggested their likely biological processes, cellular component, molecular function and involved pathways. Conclusions: Our results not only found out the potential novel metabolites and associated genes in the resistant response of soybean to soybean cyst nematode, but also provided new insights into the interactions between soybean and soybean cyst nematode.
Knowledge Domain and Emerging Trends of IgG Glycosylation: A Bibliometric Study Based on CiteSpace
Authors: Lv Jian , Chen Xueyu , Li Yuejin , Feng Xia , Zhu Kai , Li Dong , Ji Long 
Published: October 2020

Abstract
Background: The purpose of this paper is to evaluate the international scientific output of Igg glycosylation research by a stoichiometric analysis of the related papers published in the field of IGG glycosylation from 2009 to 2020, to explore the hot spot of IGG glycosylation and the evolution path of IGG glycosylation.Methods: Using the Web of Science core database (WoSCC) to collect the articles related to IgG glycosylation from 2009 to 2020 as the research object, using CiteSpace visualization software to analyze the co-occurrence of countries and institutions, core authors, and keywords. Cited authors and literature, Co-citation analysis of journals, obtaining cooperation maps of research countries / institutions and core authors, literature citation and clustering maps, co-occurrence maps of high-frequency subject headings, displaying related clusters, mutual influences between clusters and Keyword timeline view spectrum of the historical span of important keywords in clustering.Results: We searched 482 articles related to IgG glycosylation published in 227 journals, and observed that in the past 10 years, the number of articles published has generally increased year by year; it has been cited 13262 times, with an average of 27.5 citations per article, showing an upward trend year by year. The core team in the field of IGG glycosylation is mainly from University and research institutes in USA, Australia, Netherlands, Croatia, England, Germany, Ireland, Scotland, China and Japan. A total of 2408 authors participated in the writing of literature on Igg glycosylation, Among them, Wuhrer, Manfred、Lauc, Gordan、Irena Trbojevic Akmacic, Wei Wang and other scholars are the representatives of this research field and have important influence. There are 281 keywords under the theme of IgG glycosylation, of which there are 4 keywords with word frequency ≥100, and hot keywords that serve as bridges are pregnancy、complex、glycan、biosimilar、N-linked glycosylation、hilic-uplc、glycation and form 8 clusters. IgG glycosylation, as the "biomarker" of disease diagnosis and its mechanism has been a research hotspot in recent years.Conclusion: The use of CiteSpace software for quantitative analysis of IgG glycosylation related literature can intuitively demonstrate its development history and current research hotspots and trends, and can provide researchers with reference to the topic selection and research direction. Value and meaning.
Delivery of Cardiology Services in Africa During the COVID-19 Pandemic: What Should We Expect After This Pandemic?
Authors: Nganou-Gnindjio Chris Nadege , Temgoua Mazou , Kuate Liliane , Nkoke Clovis , Tochie Joel Noutakdie , Ndobo Valerie , Owona Amalia , Ba Amadou , Amougou Sylvie Ndongo , Boombhi Jerome , Menanga Alain , Kingue Samuel 
Published: October 2020

Abstract
BackgroundCOVID-19 is a global public health crisis that affects all sectors; studying the impact of this pandemic on the delivery of cardiology services in Africa is crucial as COVID-19-related cardiovascular complications may worsen the CVD burden in this already highly affected and resource-limited continentMethodsThis was a cross-sectional e-survey study conducted amongst cardiologists in African countries. The primary outcome was the change in service delivery in African cardiology units during the on-going COVID-19 pandemic. The secondary outcomes were the satisfaction of cardiologists with regards to the workload and factors associated with this satisfaction.ResultsThere was a significant reduction in working time and the number of patients consulted by week during this pandemic (p<0.001). In general, there was a decrease in the overall activities in cardiovascular care delivery. The majority of cardiology services (76.5%) and consulting programs (85%) were adjusted to the pandemic. Only half of the participants were satisfied with their workload. Reconfiguration of the consultation schedule was associated with a reduced satisfaction of participants (p=0.02).ConclusionsCOVID-19 is associated with an overall reduction in cardiology services rendered in Africa. Since the cardiovascular burdens continue to increase in this part of the World and the risk of cardiovascular complications linked to SARS COV2 remains unchanged cardiology, departments in Africa should anticipate a significant surge of cardiology services demanded by patients after the COVID-19 pandemic.
Serum HE4 as a prognostic marker in cervical cancer: a retrospective study
Authors: Hwang Woo Yeon , Suh Dong Hoon , Kim Kidong , Kim Yong Beom , No Jae Hong 
Published: October 2020

Abstract
Background

Human epididymis protein 4 (HE4) is a tumor marker that has been well-investigated in ovarian and endometrial cancers. The aim of this study was to evaluate the prognostic value of serum HE4 as a tumor marker in patients with cervical cancer.
Methods

Serum HE4 levels from 67 cervical cancer patients were measured by immunoassay before starting primary treatment between September 2014 and May 2018. A mean serum HE4 level of 72.6 pmol/L was used to divide the patients into low and high HE4 groups. The patient characteristics, clinicopathological variables, and survival outcomes were compared between the 2 groups.
Results

There were 55 (82.1%) patients in the HE4 < 72.6 pmol/L group and 12 (17.9%) patients in the HE4 > 72.6 pmol/L group at the date of diagnosis. Higher HE4 levels were significantly associated with older age at diagnosis (age < 50: 0.0% vs. age ≥ 50: 100.0%; P = 0.002), menopause (premenopause: 8.3% vs. postmenopause: 91.7%; P = 0.009), higher FIGO stage (stage I-II: 25.0% vs. III-IV: 75.5%; P = 0.008), large tumor size (< 4.0cm: 41.7% vs. ≥4.0 cm: 58.3%; P = 0.029), positive lymph node metastasis (negative: 41.7% vs. positive: 58.3%; P = 0.049), and involvement of the parametrium (negative: 25.0% vs. positive: 75.0%; P = 0.006). Higher levels of HE4 was a predictive factor for worse overall survival but not for progression-free survival, although elevated HE4 levels were not found to be independent factors for the prediction of either overall survival or progression-free survival. When subgroup analysis was performed by histological type, similar results were obtained for patients with squamous cell carcinoma.
Conclusions

Our data revealed that high levels of HE4 expression were correlated with poor OS, indicating that elevated HE4 levels are associated with a poor prognosis for patients with cervical cancer.
An analysis of invasive micropapillary breast carcinoma based on hormone receptor and epidermal growth receptor 2 status
Authors: Sun Yuting 
Published: October 2020

Abstract
Background

This research aimed to explore the role of combining hormone receptor (HR) with epidermal growth factor receptor 2 (Her-2) status of invasive micropapillary breast carcinoma (IMPC).
Methods

1291 IMPC patients were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database of the US National Cancer Institute. The X2 test and Fisher’s exact probability test were used to evaluate differences between qualitative variables. Univariate and multivariate Cox proportional hazards regressions were performed to assess the independent prognostic factors on cancer-specific survival (CSS) and overall survival (OS). The nomogram models were made to predict 3-year survival rate of IMPC using R software.
Results

Among 1291 patients, HR+/Her-2- subtype accounted for 74.7%, while HR-/Her-2+, HR-/Her-2-, HR+/Her-2 + accounted for 4.7%, 4.0% and 15.6% respectively. The X2 test indicated compared to HR+/Her-2- subgroup, HR-/Her-2- or HR+/Her-2 + subtype IMPC had larger tumor size (T stage) and higher histological grade. Compared to HR+/Her-2- IMPC, HR-/Her-2- and HR+/Her-2 + subtypes were more likely to receive mastectomy than conserving surgery. Furthermore, HR+/Her-2- IMPC had more projections to receive chemotherapy and was less likely to receive radiotherapy compared with HR-/Her-2- subtype. Survival analysis suggested that HR-/Her-2- IMPC had the worst OS and CSS.
Conclusion

This population-based study provided evidence that HR-/Her-2- IMPC accounted the smallest part of four subtypes, but were more likely to have larger tumor size and more advanced histological grade. Furthermore, HR+/Her-2- IMPC had most unfavorable prognosis among four subtypes.