bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cranial nerve V2 and Vidian nerve trauma secondary to lateral pterygoid recess encephalocele repair
Authors: Chislett Sean P. , Limjuco Alexander P. , Solyar Alla Y. , Lanza Donald C. 
Published: November 2019

BackgroundThe incidence of adverse sequelae related to trauma of cranial nerve V2 (V2) and the Vidian nerve (VN) during endoscopic pterygoid recess repair (PRR) of lateral sphenoid encephalocele is insufficiently reported in the medical literature. As part of our quality assessment and improvement program we sought to analyze the incidence and severity of V2 and VN injury during a 9‐year experience (2010‐2018) with PRR.MethodsHypoesthesia, paresthesia, and dry eye and their impact on patient quality of life were sought through chart review and a self‐reported 0 to 5 Likert scale for each symptom.ResultsThirty‐five patients underwent repair of spontaneous cerebrospinal‐fluid (CSF) rhinorrhea, with 11 consecutive patients undergoing endoscopic PRR. Mean follow‐up for PRR was 32.5 months (range, 2.4 to 103.3 months). Although definitive management resulted in 100% success, 1 required secondary treatment. Eight patients were available for long‐term follow‐up (72.7%) and completed a symptom severity questionnaire using a Likert‐scale. All patients observed either hypoesthesia, paresthesia, or dry eye of varying gradation (scale, 0 to 5). None described disabling symptoms, and some reported gradual improvement. Numbness, paresthesia, and dry eye were reported by 6 of 8 (75%), 5 of 8 (62.5%), and 4 of 8 (50%) patients, respectively. The mean Likert score among the 8 patients who completed this questionnaire noticing hypoesthesia, paresthesia, and dry eye was 2.6, 1.3, and 1.8, respectively.ConclusionMeticulous surgical technique is paramount for successful PRR and minimizing nerve injury, yet the anatomic variation of the lateral pterygoid recess can be challenging, and neural injury is a real risk. Preoperatively, patients should be counseled that although V2 or VN injury is common, most patients describe resulting symptoms to be rarely bothersome.
[SnI8{Fe(CO)4}4]2+: Highly Coordinated Sn+III8 Subunit with Fragile Carbonyl Clips
Authors: Wolf Silke , Köppe Ralf , Block Theresa , Pöttgen Rainer , Roesky Peter W. , Feldmann Claus 
Published: November 2019

Abstract[SnI8{Fe(CO)4}4][Al2Cl7]2 contains the [SnI8{Fe(CO)4}4]2+ cation with an unprecedented highly coordinated, bicapped SnI8 prism. Given the eightfold coordination with the most voluminous stable halide, it is all the more surprising that this SnI8 arrangement is surrounded only by fragile Fe(CO)4 groups in a clip‐like fashion. Inspite of a predominantly ionic bonding situation in [SnI8{Fe(CO)4}4]2+, the I−⋅⋅⋅I− distances are considerably shortened (down to 371 pm) and significantly less than the van der Waals distance (420 pm). The title compound is characterized by single‐crystal structure analysis, spectroscopic methods (EDXS, FTIR, Raman, UV/Vis, Mössbauer), thermogravimetry, and density functional theory methods.
Carbon Nanoarrays Embedded with Metal Compounds for High‐Performance Flexible Supercapacitors
Authors: Zhu Chenyu , Guan Cao , Cai Dongming , Chen Tian , Wang Yonghui , Du Junjie , Wu Jun , Xu Xi , Yu Hong , Huang Wei 
Published: November 2019

AbstractMetal‐organic frameworks (MOFs)‐derived nanoarrays have been widely used as electrode materials in energy storage applications with the unique morphology and large specific surface area. Herein, we report a series of N‐doped carbon arrays embedded with different metal compounds (noted as NC@Co3O4, NC@CoSe2 and NC@CoS2), which have been derived from a Co‐based MOF through simple fabrication processes. The resulted structures have high surface‐to‐volume ratio and short charge‐transfer paths in electrochemical reactions, which greatly benefit the energy storage performance. An asymmetric supercapacitor of NC@CoS2//Co‐NC@Fe2O3 is also demonstrated, which has a power density up to 23.5 kW/kg and illustrates good cycling stability after long‐time rapid charging and discharging. This work demonstrates a promising way to develop MOF‐derived nanoarrays for flexible energy storage devices.
Association between maternal pregestational diabetes mellitus and spina bifida: A population‐based case–control study, Finland, 2000–2014
Authors: Mowla Sanjida , Gissler Mika , Räisänen Sari , Kancherla Vijaya 
Published: November 2019

AbstractBackgroundMaternal pregestational diabetes mellitus (PGDM) is a known risk factor for neural tube defects. We examined the association between maternal PGDM and spina bifida in the offspring using PGDM status from medical records in Finland.MethodsWe conducted a nationally representative, multiregistry, population‐based case–control study in Finland. Cases were included if they were live or stillborn infants and diagnosed with spina bifida and delivered between years 2000 and 2014 in Finland. Controls were Finnish infants without spina bifida or other major structural birth defects and delivered during the same time period as cases. Clinical and demographic data were obtained by linking multiple national health registers and census. Crude and adjusted odds ratios (ORs) and 95% confidence intervals (CI) for PGDM were estimated using logistic regression analysis. Interaction by maternal obesity was examined.ResultsOur study included 181 spina bifida cases (61% isolated) and 876,672 controls. Overall, 2.2% percent of all case, and 0.5% of control mothers, had PGDM during pregnancy. Maternal PGDM was significantly associated with an increased odds of spina bifida (adjusted OR 4.35; 95% CI 1.37, 13.82). A similar association was found in our subanalysis on isolated spina bifida cases (adjusted OR 4.41; 95% CI 1.07, 18.24). There was no significant interaction by maternal obesity.ConclusionsMaternal PGDM was positively associated with spina bifida in Finland, and maternal obesity did not modify this effect. We lacked information on maternal PGDM for electively terminated and spontaneously aborted cases; results should be interpreted with caution.
Acardius anceps with neck cyst and cleft palate: Three dimensional skeletal computed tomography reconstruction with discussion of the literature
Authors: van Gemert Martin J. C. , Streekstra Geert J. , Vandenbussche Frank P. H. A. , Nikkels Peter G. J. , van den Wijngaard Jeroen P. H. M. 
Published: November 2019

AbstractAcardiac twinning is a rare anomaly of monochorionic twin pregnancies. Acardiac fetuses lack a functional heart but are passively perfused by arterial blood from their pump co‐twin causing the acardiac body to be hypoxemic. In this report, we present an acardius anceps, therapeutically laser separated from its pump twin at 16 weeks. The healthy pump twin and macerated acardiac body were born at 40 3/7 weeks. A three dimensional (3D) reconstruction was made by CT images, showing cranial bones, spinal column, pelvis and lower extremities but absent arms. A cyst in the neck of the acardiac twin was identified by postnatal sonography; this was also described in four literature cases, and was additionally observed by us in two other acardiac twins. Median cleft palate was identified by oral cavity inspection but undetectable in the reconstruction. In the literature, we found 21 other acardiac anceps twins with a cleft palate. From the two larger published series, with 12 clefts in 21 acardiac anceps twins, a cleft palate occurs in over 50% during acardiac twinning. Our first hypothesis is that acardiac fetuses develop an oral cleft palate when acardiac onset starts prior to 11 weeks, because 11 weeks includes the period of embryonic oral cavity formation, and no cleft occurs when onset starts later than 11 weeks. Our second hypothesis is that cysts and cleft palates are more common in acardiac twins than currently known, likely reflecting that acardiac bodies are hypoxemic and that hypoxia contributes to the development of both cysts and clefts.
Effects of hepatitis B virus infection and antiviral therapy on the clinical prognosis of nasopharyngeal carcinoma
Authors: Weng Jing‐Jin , Wei Jia‐Zhang , Li Min , Lu Jin‐Long , Qin Yang‐Da , Jiang He , Qu Shen‐Hong 
Published: November 2019

AbstractPurposeTo investigate the clinical characteristics of nasopharyngeal carcinoma (NPC) and a concomitant hepatitis B virus (HBV) infection, as well as the potential effects of HBV infection and antiviral therapy on prognosis.MethodsWe conducted a retrospective chart review of all NPC patients from December 2010 to December 2014. After collecting medical records and conducting follow‐ups on patients, a total of 876 eligible NPC patients were included. For each patient, medical records were reviewed. Factors predictive of outcome were compared using the log‐rank test and Cox regression analysis.ResultsAmong the 876 participants, 106 (12.1%) patients were HBV‐infected patients. The hepatitis B surface antigen‐positive [HBsAg(+)] group had a lower CD4+ T cell count than the HBsAg(−) group (P = .048). Among patients with stage I/II NPC, 5‐year overall survival (OS), disease‐free survival (DFS), relapse‐free survival, and distant metastasis‐free survival (DMFS) of the HBsAg(+) group were 82.5%, 70.7%, 87.7%, and 76.6%, respectively, whereas those of the HBsAg(−) group were 91.4%, 86.0%, 93.8%, and 92.1%, respectively. Statistically significant differences in OS, DFS, and DMFS existed between both groups (P = .017, .018, and .004, respectively). The multivariate analysis indicated that HBsAg status and N stage are independent risk factors affecting OS, DFS, and DMFS of NPC patients. A statistically significant difference in 5‐year DMFS existed between the antivirus (90.0%) and no‐antivirus groups (70.0%) (P = .043).ConclusionsHepatitis B virus infection is an independent risk factor for early stage NPC, which may be associated with its reduced immune functions compared to the HBsAg(−) group. Anti‐HBV treatment may improve the prognosis of HBV‐infected NPC patients.
Dexmedetomidine prevents desflurane‐induced motor neuron death through NF‐KappaB pathway
Authors: Liu Wenxun , Zhou Xiaohong , Wang Yun , Dong Longcai , Jia Danting , Ye Qingshan 
Published: November 2019

Desflurane is one of the commonly used general anaesthetics. Recently, it was reported that desflurane caused neurotoxicity, raising concerns in clinical use. In this study, we found desflurane could affect viability and maturation in motor neurons. Dexmedetomidine, a α2‐adrenergic receptor agonist, could attenuate the effect of desflurane on motor neurons. This process was mediated by NF‐KappaB signalling. Interestingly, we also found that dexmedetomidine could recover the lesion in motor function and memory impaired by desflurane. Collectively, our results showed the neurotoxic effect of desflurane in motor neurons. More importantly, this process was alleviated by dexmedetomidine, potentially showing its application in protecting motor neuron from neurotoxic agents.Significance of the study: This work provides the evidence to support the protective role of dexmedetomidine in desflurane‐induced motor neuron death. Since desflurane is a widely used anaesthetic in surgery and leads to neuron death, the neuroprotective effect of dexmedetomidine holds promising clinical application.
Long noncoding RNA SNHG16 promotes the tumorigenicity of cervical cancer cells by recruiting transcriptional factor SPI1 to upregulate PARP9
Authors: Tao Ling , Wang Xiyan , Zhou Qi 
Published: November 2019

AbstractLong noncoding RNA (lncRNA) small nucleolar RNA host gene 16 (SNHG16) has been linked to multiple cancers including breast, ovarian, bladder, and colorectal cancer. However, the role of SNHG16 in cervical cancer is unclear. Here, quantitative analysis of SNHG16 and PARP9 expression levels in cervical cancer tissues and cell lines indicated that both SNHG16 and PARP9 were highly expressed compared with controls. Using the dual‐luciferase reporter gene assay, RNA immunoprecipitation, chromatin immunoprecipitation, we were able to determine that SNHG16 recruited SPI1 protein to promote transcription of PARP9 to upregulate its transcription in cervical cancer cells. After ectopic expression and knockdown experiments were conducted, it was observed that silencing SNHG16 inhibited PARP9 expression, proliferation, and invasion of cervical cancer cells, which was rescued by co‐transfection of SNHG16 silencing and PARP9 overexpression. Moreover, in vivo experimental results showed that silencing SNHG16 reduced the expression of PARP9 and suppressed tumor growth. These data indicate that SNHG16 recruits SPI1 to upregulate PARP9, which promotes the tumorigenicity of cervical cancer cells. The regulation of their expression might provide a new direction for treating cervical cancer.
Microwave‐Assisted Synthesis of Copper‐Based Electrocatalysts for Converting Carbon Dioxide to Tunable Syngas
Authors: Zeng Juqin , Bejtka Katarzyna , Di Martino Gaia , Sacco Adriano , Castellino Micaela , Re Fiorentin Michele , Risplendi Francesca , Farkhondehfal M. Amin , Hernández Simelys , Cicero Giancarlo , Pirri Candido F. , Chiodoni Angelica 
Published: November 2019

AbstractCopper (Cu)‐based materials for efficient CO2 conversion to adjustable syngas are reported. We employ an energy‐efficient microwave‐assisted route to synthesize copper/copper oxides with different structures and morphologies. The initial oxidation state of the copper on the surface significantly influences the performance of the materials in the CO2 reduction reaction (CO2RR). On the as‐prepared material surface, a high content of Cu2O improves the selectivity toward CO and consequently the catalyzed CO2RR produce a syngas with a low H2/CO ratio, while the CuO performs poorly. In particular, Cu2O particles with a cubic shape show the highest selectivity for the CO formation. The superior catalytic activity of the Cu2O cubes for the CO2RR is attributed to the surface roughening under potential, which offers abundant electrochemically active sites and facilitates mass transport.
Synthesis of a Novel Petal‐Shaped Biomass‐Derived Carbon Material with Controlled Pore Structure and Nitrogen Content for Use in Supercapacitors
Authors: Zhang Luming , Zhang Xiaohua , Tian Xin , Wang Qun , Li Hengxiang , Jin Li'e , Cao Qing 
Published: November 2019

AbstractControllably adjusting the porosity and the heteroatom content has become extremely attractive for increasing the energy storage capacity of carbon materials. In this work, petal‐shaped N‐doping carbon materials with super‐high specific surface area (2752 m2 g−1) and enriched micropores (90.1 %) have been synthesized by using renewable spikes of terminalia catappa as raw materials via a facile and feasible method. The results confirmed that the prepared N‐doping carbon material exhibits outstanding electrochemical performances. The specific capacitance reaches up to 503 F g−1 at 0.5 A g−1 and 306 F g−1 at 50 A g−1; cycling stability maintains 100.2 % after 10000 cycles. The fabricated symmetric supercapacitor shows an attractive energy density of 30.5 W h Kg−1 at a power density of 492.4 W Kg−1 in 1 M Na2SO4 electrolyte. Moreover, this study opens up a new way to enhance the micropore proportion and N content of carbon materials and displays the unique petal‐shaped nano‐flakes morphology that can maximally expose the surface of carbon materials.
Flexible Molecular Precursors for Selective Decomposition to Nickel Sulfide or Nickel Phosphide for Water Splitting and Supercapacitance
Authors: Ayom Gwaza E. , Khan Malik D. , Ingsel Tenzin , Lin Wang , Gupta Ram K. , Zamisa Sizwe J. , van Zyl Werner E. , Revaprasadu Neerish 
Published: November 2019

AbstractHerein, the synthesis of three nickel(II) dithiophosphonate complexes of the type [Ni{S2P(OR)(4‐C6H4OMe)}2] [R=H (1), C3H7 (2)] and [Ni{S2P(OR)(4‐C6H4OEt}2] [R=(C6H5)2CH (3)] is described; their structures were confirmed by single‐crystal X‐ray studies. These complexes were subjected to surfactant/solvent reactions at 300 °C for one hour as flexible molecular precursors to prepare either nickel sulfide or nickel phosphide particles. The decomposition of complex 2 in tri‐octylphosphine oxide/1‐octadecene (TOPO/ODE), TOPO/tri‐n‐octylphosphine (TOP), hexadecylamine (HDA)/TOP, and HDA/ODE yielded hexagonal NiS, Ni2P, Ni5P4, and rhombohedral NiS, respectively. Similarly, the decomposition of complex 1 in TOPO/TOP and HDA/TOP yielded hexagonal Ni2P and Ni5P4, respectively, and that of complex 3 in similar solvents led to hexagonal Ni5P4, with TOP as the likely phosphorus provider. Hexagonal NiS was prepared from the solvent‐less decomposition of complexes 1 and 2 at 400 °C. NiS (rhom) had the best specific supercapacitance of 2304 F g−1 at a scan rate of 2 mV s−1 followed by 1672 F g−1 of Ni2P (hex). Similarly, NiS (rhom) and Ni2P (hex) showed the highest power and energy densities of 7.4 kW kg−1 and 54.16 W kg−1 as well as 6.3 kW kg−1 and 44.7 W kg−1, respectively. Ni5P4 (hex) had the lowest recorded overpotential of 350 mV at a current density of 50 mA cm−2 among the samples tested for the oxygen evolution reaction (OER). NiS (hex) and Ni5P4 (hex) had the lowest overpotentials of 231 and 235 mV to achieve a current density of 50 mA cm−2, respectively, in hydrogen evolution reaction (HER) examinations.
Two π‐Electrons Make the Difference: From BODIPY to BODIIM Switchable Fluorescent Dyes
Authors: Dolati Hadi , Haufe Lisa C. , Denker Lars , Lorbach Andreas , Grotjahn Robin , Hörner Gerald , Frank René 
Published: November 2019

Abstract(aza‐)BODIPY dyes (boron dipyrromethene dyes) are well‐established fluorophores due to their large quantum yields, stability, and diversity, which led to promising applications including imaging techniques, sensors, organic (opto)electronic materials, or biomedical applications. Although the control of the optical properties in (aza‐)BODIPY dyes by peripheral functional groups is well studied, we herein present a novel approach to modify the 12 π‐electron core of the dipyrromethene scaffold. The replacement of two carbon atoms in the β‐position of a BODIPY dye by two nitrogen atoms afforded a 14 π‐electron system, which was termed BODIIM (boron diimidazolylmethene) in systematic analogy to the BODIPY dyes. Remarkably, the BODIIM dye was obtained with a BH2‐rigidifying entity, which is currently elusive and highly sought after for the BODIPY dye class. DFT‐Calculations confirm the [12+2] π‐electron relationship between BODIPY and BODIIM and reveal a strong shape correlation between LUMO in the BODIPY and the HOMO of the BODIIM. The modification of the π‐system leads to a dramatic shift of the optical properties, of which the fluorescent emission is most noteworthy and occurs at much larger Stokes shift, that is, ≈500 cm−1 in BODIPY versus >4170 cm−1 in BODIIM system in all solvents investigated. Nucleophilic reactivity was found at the meso‐carbon atom in the formation of stable borane adducts with a significant shift of the fluorescent emission, and this behavior contrasts the reactivity of conventional BODIPY systems. In addition, the reverse decomplexation of the borane adducts was demonstrated in reactions with a representative N‐heterocyclic carbene to retain the strongly fluorescent BODIIM compound, which suggests applications as fully reversible fluorescent switch.
Repurposing of FDA‐Approved Drugs for Treating Iatrogenic Botulism: A Paired 3D‐QSAR/Docking Approach†
Authors: Floresta Giuseppe , Patamia Vincenzo , Gentile Davide , Molteni Franco , Santamato Andrea , Rescifina Antonio , Vecchio Michele 
Published: November 2019

AbstractBotulinum neurotoxin (BoNT) is widely used for the treatment of spasticity, focal dystonia, chronic migraine, facial hemispasm, and facial aesthetic treatments. Generally, treatment with botulinum toxin is a safe procedure when conducted by clinicians with expertise, and local side effects are rare and transient. However, occasionally adverse effects can occur due to the spread of the drug to nontargeted muscles and organs, producing dry mouth, fatigue, and flu‐like symptoms, up to signs of systemic botulism, which appears to be more frequent in children treated for spasticity than in adults. In silico 3D‐QSAR and molecular docking studies were performed to build a structure‐based model on selected potent known botulinum neurotoxin type A inhibitors; this was used to screen the US Food and Drug Administration (FDA) database. Thirty molecules were identified as possible light‐chain BoNT/A inhibitors. In this study, we applied a well‐established ligand‐ and structure‐based methodology for the identification of hit compounds among a database of FDA‐approved drugs. The identification of budesonide, protirelin, and ciclesonide followed by other compounds can be considered a starting point for investigations of selected compounds that could bypass much of the time and costs involved in the drug approval process.
Fertility‐sparing surgery and survival among reproductive‐age women with epithelial ovarian cancer in 2 cancer registries
Authors: Crafton Sarah M. , Cohn David E. , Llamocca Elyse N. , Louden Elaine , Rhoades Jennifer , Felix Ashley S. 
Published: November 2019

BackgroundThis study examined predictors of fertility‐sparing surgery (FSS) among reproductive‐age women diagnosed with epithelial ovarian cancer (EOC). In addition, relationships between FSS and survival were assessed in models stratified by tumor characteristics.MethodsThe Surveillance, Epidemiology, and End Results (SEER) program and the National Cancer Database (NCDB) were queried for women 44 years old or younger with a primary EOC. FSS included unilateral salpingo‐oophorectomy and uterine preservation, whereas surgeries including bilateral salpingo‐oophorectomy and hysterectomy were categorized as non‐FSS. Logistic regression was used to estimate multivariable‐adjusted odds ratios and 95% confidence intervals (CIs) for associations between clinical characteristics (eg, age at diagnosis and race) and FSS odds. Multivariable Cox regression was used to estimate hazard ratios (HRs) and 95% CIs for FSS and overall survival in subgroups defined by stage and grade or by stage and histology. Analyses were stratified by database (SEER vs NCDB).ResultsThis analysis included 9017 women (SEER, n = 3932; NCDB, n = 5085) with EOC diagnosed between the ages of 15 and 44 years. In both cohorts, factors associated with significantly higher FSS odds included a younger age, a more recent ovarian cancer diagnosis, and no adjuvant chemotherapy. FSS was significantly associated with lower overall survival among women with stage II to IV, serous EOC (SEER HR, 1.61; 95% CI, 1.22‐2.12). Significant associations between FSS and survival were not observed in other subgroups defined by stage and grade or by stage and histology.ConclusionsFSS appears to be safe for certain women with EOC but was related to poor survival among women with advanced‐stage, serous EOC. Confirmatory studies with information on fertility intentions are needed.