bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prepared to Respond? Exploring Personal Disaster Preparedness and Nursing Staff Response to Disasters
Authors: Adams Lavonne M. , Melius Joyce 
Published: May 2020

ABSTRACTObjectives:This pilot study explored personal disaster preparedness of nursing staff and their ability and willingness to respond following a disaster.Methods:All nurses from a single hospital were invited to participate; 91 completed an online survey asking them to rate their ability and willingness to report to work following the disaster scenarios and to indicate whether they had pursued various preparedness activities. Data were analyzed by descriptive and inferential statistics using Minitab 17 Statistical Software.Results:Participants reflected a cross-section of major acute care units and nursing specialties. The majority of participants indicated being able and willing to report to work following the disaster scenarios. Personal disaster preparedness varied, with few activities pursued by the majority. Few scenarios produced a relationship between preparedness activities and ability or willingness to report to work.Conclusions:Despite the majority of participants indicating they would be able and willing to report to work during a disaster, they acknowledged barriers affecting them. Most disaster scenarios showed no statistically significant relationship with preparedness activities. Nurses should consider barriers that affect their own availability for work following a disaster and identify potential solutions. Future research related to mitigation of possible barriers to surge capacity would be useful.
Tunable optical frequency comb from a compact and robust Er:fiber laser
Authors: Zhu Zhiwei , Liu Yang , Luo Daping , Gu Chenglin , Zhou Lian , Xie Gehui , Deng Zejiang , Li Wenxue 
Published: May 2020

We report on a compact and robust self-referenced optical frequency comb with a tunable repetition rate, generated by an all-polarization-maintaining (PM) mode-locked Er-doped fiber laser. The spacing between comb teeth can be tuned above 300 kHz at a repetition rate of 101 MHz. The repetition rate and the carrier–envelope offset of the laser are stabilized separately, and the relative residual phase noises are determined to be

$336~\unicode[STIX]{x03BC}\text{rad}$

and 713 mrad (1 Hz–1 MHz). The accurate frequency characteristics and the stable structure show great potential for the use of such a comb in applications of precision measurements.
Free Vibration Analysis of Lock Gate Structure
Authors: Singh Deepak Kumar , Pal Priyaranjan , Duggal S. K. 
Published: May 2020

ABSTRACTThe effect of fluid on the natural frequencies of a vertical rectangular lock gate is investigated. The fluid is assumed to be inviscid and incompressible having an irrotational flow field. The far boundary of fluid domain is truncated near the lock gate structure by solving the Laplace equation using Fourier half range cosine series expansion. The formulation of lock gate structure is governed using Mindlin’s plate theory. The coupled interaction between the fluid domain and the lock gate structure is established using finite element method (FEM) and a computer code is written using FORTRAN. Convergence study and validation of the formulation are carried out to minimise the computational error. The natural frequencies of lock gate coupled with and without fluid are determined for undisturbed and linearised free surface conditions. By varying extent of fluid domain, the effect on the natural frequencies of lock gate is evaluated. The results of natural frequencies obtained may be useful to the designer when the reservoir lock gate structure is exposed to the natural disasters.
Investigation of Bending Stiffness of Gas Turbine Engine Rotor Flanged Connection
Authors: Nizametdinov F.R. , Romashin Yu.S. , Berne A.L. , Leontyev M.K. 
Published: May 2020

ABSTRACTThe article deals with the modeling of stiffness properties of the rotors flange joints, which largely determine overall dynamics. Research is conducted on the example of the standard compressor shaft flange connection and the disk of the high-pressure turbine in the gas generator of the gas turbine engine (GTE). It is noted that the bending stiffness of the flange connection is a nonlinear function of the bending moment, whose both experimental and analysis magnitude is related to the rotor deflection from the unbalanced forces. It is shown that the value of the bending stiffness essentially depends not upon the flange connection geometry but on the bolts tightening force, the axial force, the tensile joint, the contact strain of the flange surfaces. Analysis of the effect obtained in different models of the flange connection of the bending stiffness values on the overall dynamics of the rotor showed the necessity of taking into account the entire set of factors acting in the joint.
Australia's earliest tetrapod swimming traces from the Hawkesbury Sandstone (Middle Triassic) of the Sydney Basin
Authors: Farman Roy M. , Bell Phil R. 
Published: May 2020

AbstractThe Hawkesbury Sandstone (Hawkesbury Series, Sydney Basin) on the southeastern coast of New South Wales, Australia, preserves a depauperate but important vertebrate tetrapod body-fossil record from the Early and Middle Triassic. As with many fossil sites around the world, the ichnological record has helped to shed light on the paleoecology of this interval. Herein, we investigate historical reports of a trackway pertaining to a putative short-tailed reptile found at Berowra Creek in the 1940s. Reinvestigation of the surviving track-bearing slabs augmented by archival photographs of the complete trackway, suggests that these impressions, which consist primarily of didactyl tracks (plus less common monodactyl and tridactyl traces), represent the earliest example of a swimming tetrapod found in Australia. Another isolated specimen (possibly from a nearby locality at Annangrove) appears to represent similar didactyl swim traces of a second, larger individual. Although the identities of the trackmakers are unknown, the Berowra Creek individual had an estimated body length of between ~80 cm (short-coupled) and 1.35 m (long-coupled), and produced the subaqueous trackway while travelling upslope (against the current) on a sandbar within a braided river system of the Hawkesbury Sandstone. These trackways partially resemble amphibian swim traces in the so-called Batrachichnus C Lunichnium continuum, but appear to represent a unique locomotion trace. This reanalysis of the Berowra Creek trackway provides insight into the locomotion of tetrapods of the Triassic Hawkesbury Series, which remains a poorly understood aspect of their life history.
Exploring test batteries for depression- and anxiety-like behaviours in female and male ICR and black Swiss mice
Authors: Kazavchinsky Lydmila , Dahan Sofi , Einat Haim 
Published: May 2020

AbstractObjective and rationale: Animal models are critical for the study of mental disorders and their treatments but are repeatedly criticized for problems with validity and reproducibility. One approach to enhance validity and reproducibility of models is to use test batteries rather than single tests. Yet, a question regarding batteries is whether one can expect a consistent individual behavioural phenotype in mice across tests that can be presumed to be part of the same construct. This study was designed to explore the relationship between the behaviours of mice across tests in some variations of test batteries for depression- and anxiety-like behaviours. Methods: Female and male healthy, intact, and untreated mice from the ICR and black Swiss strains were used in four separate experiments. With some variations, mice were exposed to a battery of behavioural tests representing affective- and anxiety-like behaviours. Data were analysed for differences between sexes and for correlations between behaviours within and across the tests in the battery. Results: No differences were found between the sexes. With very few exceptions, we found correlations within tests (when one test has more than one measure or is repeated) but not across different tests within the battery. Conclusions: The results cast some doubt on the utility of behavioural test batteries to represent different facets of emotional behaviour in healthy intact outbred mice, without any interventions or treatments. Additional studies are designed to explore whether stronger relationship between the tests will appear after manipulations or drug treatments.
NONBINARY DELSARTE–GOETHALS CODES AND FINITE SEMIFIELDS
Authors: RÚA IGNACIO F. 
Published: May 2020

AbstractSymplectic finite semifields can be used to construct nonlinear binary codes of Kerdock type (i.e., with the same parameters of the Kerdock codes, a subclass of Delsarte–Goethals codes). In this paper, we introduce nonbinary Delsarte–Goethals codes of parameters
$(q^{m+1}\ ,\ q^{m(r+2)+2}\ ,\ {\frac{q-1}{q}(q^{m+1}-q^{\frac{m+1}{2}+r})})$
over a Galois field of order
$q=2^l$
, for all
$0\le r\le\frac{m-1}{2}$
, with m ≥ 3 odd, and show the connection of this construction to finite semifields.
Selection of nonlinear mixed models for growth curves of dairy buffaloes (Bubalus bubalis)
Authors: Araujo Neto F. R. , Oliveira D. P. , Aspilcueta-Borquis R. R. , Vieira D. A. , Guimarães K. C. , Oliveira H. N. , Tonhati H. 
Published: May 2020

AbstractThe determination of livestock growth patterns is important for meat or milk production systems, and nonlinear models are used to summarize and interpret the information. The aim of this study was to more accurately estimate growth curve parameters in buffalo cows by evaluating and selecting nonlinear mixed models that employ different types of residuals and include or not contemporary groups (CG) as a covariate. Weight records from 720 animals obtained over a period of 60 months were used. The growth curves were fit using nonlinear mixed-effects models. The Bertalanffy, Gompertz and Logistic models were evaluated. Modelling residuals using four structures (constant, combined, exponential and proportional) and the inclusion or not of CG in the models were also evaluated. The Akaike information criterion (AIC) and Bayesian information criterion (BIC) were used to select the model. In addition to estimating the parameters of the nonlinear growth models and their correlations, the instantaneous growth rate and inflection point were obtained. The Bertalanffy model with a combined residual structure and CG exhibited the lowest AIC and BIC values. Asymptotic weight (A) estimates ranged from 621.8 to 742.1 kg, and the maturity rate (k) ranged from 0.068 to 0.115 kg/month. The correlation between A and k ranged from −0.32 to −0.82 among the models evaluated. The selection criteria indicated that the Bertalanffy model was the most suitable for growth curve analysis in buffaloes.
Next year, if grain is dear, I shall be a Sayyid: Sayyid Ahmad Khan, colonial constructions, and Muslim self-definitions
Authors: LELYVELD DAVID 
Published: May 2020

AbstractBritish social surveys and census statistics defined ‘Sayyid’ as a caste identity, while often casting a sceptical eye on the authenticity of genealogical claims associated with the concept. The article examines how Muslims, especially Sayyid Ahmad Khan, participated in the formulation of the concept of Sayyid identity and status. Islamic ideology and practice have long wrestled with conflicting claims of religious equality and hierarchical status, often based on concepts of sacred lineage. From his earliest writings Sayyid Ahmad Khan (1817–98) emphasised his descent from the Prophet Muhammad on his father's side alongside his somewhat less exalted relationship with his Kashmiri grandfather. In later years he tried to balance universalistic ideals with claims to status based on supposedly ‘foreign’ ancestry, which he cited as parallel to the supposed Aryan ancestry of high-status Hindus. His British allies used his Sayyid ancestry as reinforcement of his leadership of an India-wide Muslim ‘community’ and evidence that India was not prepared to develop into a national polity based on representative government. But the Aligarh movement's claim to represent the wider Muslim population and in particular its educational project at Aligarh struggled with a more egalitarian ethos, defining students and the members of voluntary associations as ‘brothers’, and quite prepared to cross ascriptive boundaries both in public life and personal relationships.
Contract work at older ages
Authors: Abraham Katharine G. , Hershbein Brad , Houseman Susan N. 
Published: May 2020

AbstractThe share of workers who are self-employed rises markedly with age. Given policy concerns about inadequate retirement savings, especially among those with lower education, and the resulting interest in encouraging employment at older ages, it is important to understand the role that self-employment arrangements play in facilitating work among seniors. New data from a survey module fielded on a Gallup telephone survey distinguish independent contractor work from other self-employment and provide information on informal and online platform work. The Gallup data show that, especially after accounting for individuals who are miscoded as employees, self-employment is even more prevalent at older ages than suggested by existing data. Work as an independent contractor is the most common type of self-employment. Roughly one-quarter of independent contractors aged 50 and older work for a former employer. At older ages, self-employment generally – and work as an independent contractor specifically – is more common among the highly educated, accounting for much of the difference in employment rates across education groups. We provide suggestive evidence that differences in opportunities for independent contractor work play an important role in the lower employment rates of less-educated older adults.
SYMBOLIC ANALYTIC SPREAD: UPPER BOUNDS AND APPLICATIONS
Authors: Dao Hailong , Montaño Jonathan 
Published: May 2020

AbstractThe symbolic analytic spread of an ideal $I$ is defined in terms of the rate of growth of the minimal number of generators of its symbolic powers. In this article, we find upper bounds for the symbolic analytic spread under certain conditions in terms of other invariants of $I$. Our methods also work for more general systems of ideals. As applications, we provide bounds for the (local) Kodaira dimension of divisors, the arithmetic rank, and the Frobenius complexity. We also show sufficient conditions for an ideal to be a set-theoretic complete intersection.
Pesticide regulation in the European Union and the glyphosate controversy
Authors: Kudsk Per , Mathiassen Solvejg Kopp 
Published: May 2020

AbstractThe glyphosate controversy before the renewal of the authorization of glyphosate in the European Union (EU) once again turned the spotlight on pesticide regulation in the EU. In the EU, pesticides are attracting more public attention than in other parts of the world, and many nongovernmental organizations specifically target pesticide regulation, trying to influence politicians and other decision makers. Following an overview of the EU pesticide legislation and the impact hitherto on EU agriculture, this paper outlines the glyphosate controversy and presents the outcome of desk studies conducted in Germany, the United Kingdom, France, and Sweden on the potential effects of a glyphosate ban on agricultural productivity and farm income. All studies concluded that the loss of income depends very much on farm type and cropping practice, but they all reached the conclusion that particularly no-tillage farming/conservation agriculture will be facing severe problems without glyphosate to control weeds and terminate cover crops. No-tillage/conservation agriculture is viewed as an effective strategy to prevent soil erosion and loss of nutrients, which could become larger problems without glyphosate. Other issues highlighted in the studies were the impact on resistance management, as glyphosate is largely seen as a “herbicide-resistance breaker.” Without glyphosate, fundamental changes in farming practices in the EU are required, and it is hard to imagine that they will come without a cost, at least in the short term.
Oncogenic super-enhancer formation in tumorigenesis and its molecular mechanisms
Authors: Jia Qunying , Chen Shuhua , Tan Yuan , Li Yuejin , Tang Faqing 
Published: May 2020

AbstractSuper-enhancers (SEs) consist of a cluster of many enhancers bound to a great number of transcription factors. They are critical cis-regulatory elements that determine the identity of various human cell types. During tumorigenesis, DNA mutations and indels, chromosomal rearrangements, three-dimensional chromatin structural changes, and viral infections mediate oncogenic SE activation, and activated SEs have been found to regulate the expression of oncogenic genes. Inhibition specifically targeted to oncogenic SE assembly and activation provides a novel powerful therapeutic strategy for various cancers. In this paper, we first introduce the current understanding of oncogenic SE assembly and activation and then summarize the pathogenic factors and mechanism of oncogenic SE activation. Next, we elaborate on the oncogenic functions of SEs in cancers and the application of SEs as therapeutic targets. Finally, we turn our focus to the use of SEs in basic research and clinical trials.
TRIM11 facilitates chemoresistance in nasopharyngeal carcinoma by activating the β-catenin/ABCC9 axis via p62-selective autophagic degradation of Daple
Authors: Zhang Runa , Li Si-Wei , Liu Lijuan , Yang Jun , Huang Guofu , Sang Yi 
Published: May 2020

AbstractChemotherapy resistance is the major cause of nasopharyngeal carcinoma (NPC) treatment failure. Tripartite motif-containing protein (TRIM) family members play important roles in tumor development and chemotherapy failure. Here, based on a screening analysis of 71 TRIM family members by qRT-PCR, we first confirmed that the TRIM11 levels were significantly higher in drug-resistant NPC cells than in non-drug-resistant NPC cells, and high TRIM11 expression predicted poor overall survival (OS) and progression-free survival (PFS). N(6)-Methyladenosine (m6A) was highly enriched in TRIM11 in NPC drug-resistant cells and enhanced its RNA stability. TRIM11 enhanced the multidrug resistance in NPC by inhibiting apoptosis in vitro and promoting cisplatin (DDP) resistance in vivo. TRIM11 associated with Daple and promoted Daple ubiquitin-mediated degradation in a p62-selective autophagic manner, further upregulating β-catenin expression to induce ABCC9 expression by directly binding to the ABCC9 promoter. TRIM11 may regulate NPC drug resistance by positively modulating the Daple/β-catenin/ABCC9 signaling pathway. Thus, TRIM11 may be a potential diagnostic marker and therapeutic target for chemoresistant NPC.
Clinical utility of the exosome based ExoDx Prostate(IntelliScore) EPI test in men presenting for initial Biopsy with a PSA 2–10 ng/mL
Authors: Tutrone Ronald , Donovan Michael J. , Torkler Phillipp , Tadigotla Vasisht , McLain Tom , Noerholm Mikkel , Skog Johan , McKiernan James 
Published: May 2020

Abstract
Background
The ExoDx Prostate(IntelliScore) (EPI) test is a non-invasive risk assessment tool for detection of high-grade prostate cancer (HGPC) that informs whether to proceed with prostate biopsy. We sought to assess the impact of EPI on the decision to biopsy in a real-world clinical setting.

Methods
We conducted a prospective, randomized, blinded, two-armed clinical utility study that enrolled 1094 patients with 72 urologists from 24 urology practices. Patients were considered for prostate biopsy at enrollment based on standard clinical criteria. All patients had an EPI test; however, patients were randomized into EPI vs. control arms where only the EPI arm received results for their biopsy decision.

Results
In the EPI arm (N = 458), 93 patients received negative EPI scores of which 63% were recommended to defer biopsy by the urologist and 74% ultimately deferred. In contrast, 87% of patients with positive EPI scores were recommended to undergo biopsy with a 72% compliance rate to the urologist’s recommendation. This led to detection of 30% more HGPC compared to the control arm, and we estimate that 49% fewer HGPC were missed due to deferrals compared to standard of care (SOC). Overall, 68% of urologists reported that the EPI test influenced their biopsy decision. The primary reason not to comply with EPI results was rising PSA.

Conclusion
To our knowledge this is the first report on a PC biomarker utility study with a blinded control arm. The study demonstrates that the EPI test influences the overall decision to defer or proceed with a biopsy and improves patient stratification.
WTAP and BIRC3 are involved in the posttranscriptional mechanisms that impact on the expression and activity of the human lactonase PON2
Authors: Carusone Teresa Maria , Cardiero Giovanna , Cerreta Mariangela , Mandrich Luigi , Moran Oscar , Porzio Elena , Catara Giuliana , Lacerra Giuseppina , Manco Giuseppe 
Published: May 2020

AbstractThe activity of human paraoxonase 2 (PON2) is rapidly reduced in cells incubated with the bacterial quorormone 3-Oxo-dodecanoyl Homoserine Lactone (3OC12HSL), an observation that led to hypothesize a fast PON2 post-translational modification (PTM). Recently, we detected a 3OC12HSL-induced PTM in a cell-free system in which a crude extract from 3OC12HSL-treated HeLa cells was able to inactivate and ubiquitinate at position 144 a recombinant PON2. Here we show the occurrence of this and new PTMs on PON2 in HeLa cells. PTMs were found to gather nearby the two SNPs, A148G, and S311C, that are related to type-2 diabetes and its complications. Furthermore, we detected a PTM nearby a 12 amino acids region that is deleted in PON2 Isoform 2. An in vitro mutation analysis showed that the SNPs and the deletion are involved in PON2 activity and suggested a role of PTMs on its modulation, while a SAXS analysis pointed to Isoform 2 as being largely unstructured, compared to the wild type. Besides, we discovered a control of PON2 expression via a putative mRNA operon involving the Wilms tumor 1 associated protein (WTAP) and the E3 ubiquitin ligase (E3UbL) baculoviral IAP repeat-containing 3 (BIRC3).
Exosomes derived from hucMSC attenuate renal fibrosis through CK1δ/β-TRCP-mediated YAP degradation
Authors: Ji Cheng , Zhang Jiahui , Zhu Yuan , Shi Hui , Yin Siqi , Sun Fengtian , Wang Qiongni , Zhang Leilei , Yan Yongmin , Zhang Xu , Xu Wenrong , Qian Hui 
Published: May 2020

AbstractExosomes from human umbilical cord mesenchymal stem cells (hucMSC-Ex) have been suggested as novel nanomaterials for regenerative medicine. Here we explored the roles of hucMSC-Ex through regulating Yes-associated protein (YAP) in renal injury repair by using rat unilateral ureteral obstruction (UUO) models. Our study identified mechanical stress induced YAP nucleus expression and stimulated collagen deposition and interstitial fibrosis in the kidney. Then, infusion with hucMSC-Ex promoted YAP nuclear cytoplasmic shuttling and ameliorated renal fibrosis in UUO model. Interestingly, hucMSC-Ex delivered casein kinase 1δ (CK1δ) and E3 ubiquitin ligase β-TRCP to boost YAP ubiquitination and degradation. Knockdown of CK1δ and β-TRCP in hucMSC decreased the repairing effects of hucMSC-Ex on renal fibrosis. Our results suggest that hucMSC-Ex attenuates renal fibrosis through CK1δ/β-TRCP inhibited YAP activity, unveiling a new mechanism for the therapeutic effects of hucMSC-Ex on tissue injury and offering a potential approach for renal fibrosis treatment.