bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship of Total and Free 25-Hydroxyvitamin D to Biomarkers and Metabolic Indices in Healthy Children
Authors: Simpson Christine A , Zhang Jane H , Vanderschueren Dirk , Fu Lei , Pennestri Teresita C , Bouillon Roger , Cole David E C , Carpenter Thomas O 
Published: November 2019

Abstract

Context
Vitamin D status is usually assessed by serum total 25-hydroxyvitamin D (t25-OHD). Whether free 25-hydroxyvitamin D measures better correlate with various clinical outcomes is unclear.

Objective
To identify correlations between t25-OHD, calculated and direct measures of free 25-OHD, and to identify associations of these measures with other outcomes in children, across the 6 common GC haplotypes.

Design
Healthy urban-dwelling children underwent measurement of relevant variables.

Setting
Academic medical center.

Participants
The study included 203 healthy, urban-dwelling children, aged 6 months to 10 years, predominantly of Hispanic background and representative of all common GC haplotypes.

Intervention
None.

Main Outcome Measures
Total and free 25-OHD and 1,25(OH)2D, calcium, phosphate, parathyroid hormone (PTH), glucose, insulin, aldosterone, and renin.

Results
Mean t25-OHD [26.3 ± 6.7ng/ml; 65.8 ± 16.8nmol/L] were lowest in the GC2 genotype. Mean t1,25(OH)2D [57.6 ± 16.5pg/ml; 143.9 ± 41.3pmol/L], were lowest in GC1f/1f, GC1f/2, and GC2/2 groups. T25-OHD correlated strongly with calculated free 25-OHD (cf25-OHD) (r = 0.89) and moderately with directly measured free 25-OHD (dmf25-OHD) (r = 0.69). Cf25-OHD correlated with dmf25-OHD (r = 0.69) (P &lt; 0.001 for all). t25-OHD inversely correlated with body mass index (BMI) (r=-0.191; P = 0.006), skin reflectometry, and systolic blood pressure. T25-OHD correlated with fasting insulin and the homeostatic model assessment for insulin resistance (HOMA-IR), however significance for these correlations was not evident after adjustment for BMI. PTH inversely correlated with all measures of 25-OHD, but most strongly with t25-OHD.

Conclusions
Measures of circulating total and free 25-OHD are comparable measures of vitamin D status in heathy children. Correlations are similar with other outcome variables, however t25-OHD remains the strongest correlate of circulating PTH and other variables. These data argue against routine refinement of the t25-OHD measure using currently available assessments of free 25-OHD.

Clinical Trial Information
Clinicaltrials.gov registration no: NCT01050387 (January 15, 2010).
Evidence-based Clinical Decision Support Systems for the prediction and detection of three disease states in critical care: A systematic literature review
Authors: Medic Goran , Kosaner Kließ Melodi , Atallah Louis , Weichert Jochen , Panda Saswat , Postma Maarten , EL-Kerdi Amer 
Published: November 2019

Background:Clinical decision support (CDS) systems have emerged as tools providing intelligent decision making to address challenges of critical care. CDS systems can be based on existing guidelines or best practices; and can also utilize machine learning to provide a diagnosis, recommendation, or therapy course.Methods:This research aimed to identify evidence-based study designs and outcome measures to determine the clinical effectiveness of clinical decision support systems in the detection and prediction of hemodynamic instability, respiratory distress, and infection within critical care settings. PubMed, ClinicalTrials.gov and Cochrane Database of Systematic Reviews were systematically searched to identify primary research published in English between 2013 and 2018. Studies conducted in the USA, Canada, UK, Germany and France with more than 10 participants per arm were included.Results:In studies on hemodynamic instability, the prediction and management of septic shock were the most researched topics followed by the early prediction of heart failure. For respiratory distress, the most popular topics were pneumonia detection and prediction followed by pulmonary embolisms. Given the importance of imaging and clinical notes, this area combined Machine Learning with image analysis and natural language processing. In studies on infection, the most researched areas were the detection, prediction, and management of sepsis, surgical site infections, as well as acute kidney injury. Overall, a variety of Machine Learning algorithms were utilized frequently, particularly support vector machines, boosting techniques, random forest classifiers and neural networks. Sensitivity, specificity, and ROC AUC were the most frequently reported performance measures.Conclusion:This review showed an increasing use of Machine Learning for CDS in all three areas. Large datasets are required for training these algorithms; making it imperative to appropriately address, challenges such as class imbalance, correct labelling of data and missing data. Recommendations are formulated for the development and successful adoption of CDS systems.
Perceived facilitators and barriers of enrolment, participation and adherence to a family based structured lifestyle modification interventions in Kerala, India: A qualitative study
Authors: Joseph Linju M. , Lekha T. R. , Boban Dona , Jose Prinu , Jeemon Panniyammakal 
Published: November 2019

Background: The objective of the study was to describe participants’ and providers’ perspectives of barriers and facilitators of enrolment, participation and adherence to a structured lifestyle modification (SLM) interventions as part of the PROLIFIC trial in Kerala, India. Methods: Family members who had been enrolled for 12-months or more in a family-based cardiovascular risk reduction intervention study (PROLIFIC Trial) were purposively sampled and interviewed using a semi-structured guide. The non-physician health workers (NPHWs) delivering the intervention were also interviewed or included in focus groups (FGDs). Thematic analysis was used for data analysis. Results: In total, 56 in-depth interviews and three FGDs were conducted. The descriptive themes emerged were categorised as (a) motivation for enrolment and engagement in the SLM interventions, (b) facilitators of adherence, and (c) reasons for non-adherence. A prior knowledge of familial cardiovascular risk, preventive nature of the programme, and a reputed organisation conducting the intervention study were appealing to the participants. Simple suggestions of healthier alternatives based on existing dietary practices, involvement of the whole family, and the free annual blood tests amplified the adherence. Participants highlighted regular monitoring of risk factors and provision of home-based care by NPHWs as facilitators for adherence. Furthermore, external motivation by NPHWs in setting and tracking short terms goals were perceived as enablers of adherence. Nonetheless, home makers expressed difficulty in dealing with varied food choices of family members. Young adults in the programme noted that dietary changes were affected by eating out as they wanted to fit in with peers. Conclusions: The findings suggest that a family-based, trained healthcare worker led SLM interventions are desirable and feasible in Kerala. Increasing the number of visits by NPHWs, regular monitoring and tracking of lifestyle goals, and targeting young adults and children for dietary changes may further improve adherence to SLM interventions.
Ekofilozofia w perspektywie oikologicznej na przykładzie procesu postindustrializacji
Authors: Tofilski Mateusz 
Published: November 2019

Oikologia to nauka o domu rozumianym szeroko, w kontekście dialektyki zakorzenienia człowieka w świecie, jako relacja zachodząca między nim a otaczającą go rzeczywistością. Dotyka w swojej analizie m.in. pytań z zakresu etyki środowiska dotyczących ludzkiej ingerencji w strukturę świata i stara się wspierać refleksję i wynikającą z niej postawę pełną wrażliwości na związek człowieka ze środowiskiem.
Ekofilozofia, jako dyscyplina podejmująca wieloaspektową problematykę ochrony środowiska z perspektywy filozoficznej refleksji, w centrum zainteresowania stawia również badanie samej relacji łączącej człowieka ze środowiskiem przyrodniczym. Celem artykułu jest wskazanie, iż refleksja oikologiczna może okazać się pomocną perspektywą dla szeroko pojętej ekofilozofii, a więc właśnie dla rozważań skupiających się na odpowiednim ułożeniu wspomnianej interakcji. Przykładem praktycznego problemu, w którym tego typu spojrzenie zostanie zaprezentowane, jest kwestia przestrzeni miejskiej, a konkretniej jej rewitalizacji, ze szczególnym naciskiem na obszary poprzemysłowe, którą w omawianym kontekście ekofilozofii wiąże się przede wszystkim z ideą zrównoważonego rozwoju.
Bayesian Nonparametrics and Biostatistics: The Case of PET Imaging
Authors: Fall Mame Diarra 
Published: November 2019

AbstractBiostatistic applications often require to collect and analyze a massive amount of data. Hence, it has become necessary to consider new statistical paradigms that perform well in characterizing complex data. Nonparametric Bayesian methods provide a widely used framework that offers the key advantages of a fully model-based probabilistic framework, while being highly flexible and adaptable. The goal of this paper is to provide a motivation of Bayesian nonparametrics (BNP) through a particular biomedical application, namely Positron Emission Tomography (PET) imaging reconstruction.
A Farewell to Monetization
Authors: Wang Lei 
Published: November 2019

Abstract
This paper inquires the nature of monetization with the positive transaction costs approach. It is argued that the nature of monetization is marketization. Once a market emerges, its monetization would be practically 100 %. The huge efforts devoted to measure monetization are thus chasing a mission impossible, and the policy implications derived from these measures are possibly misleading. The study of this paper suggests that it could be beneficial to discard the concept of monetization in the study of financial development and illustrates the importance of the systematic inclusion of transaction costs into economic analysis.
Adsorption performance of hydrophobic/hydrophilic silica aerogel for low concentration organic pollutant in aqueous solution
Authors: Yi Zhigang , Tang Qiong , Jiang Tao , Cheng Ying 
Published: November 2019

Abstract
Hydrophobic silica aerogels (SiO2(AG)) was prepared via sol-gel and solvent exchange method under ambient pressure, which could be transformed to hydrophilic after heated under 500∘C. Heat treatment cannot change its structure. SiO2(AG) samples were the micro-porous structure formed by numerous fine particles and had high specific surface area, pore size and pore volume. The absorption performance of hydrophobic/hydrophilic SiO2(AG) on nitrobenzene, phenol and methylene blue (MB) showed that hydrophobic SiO2(AG) exhibited strong adsorption capacity on slightly soluble organic compounds, while hydrophilic SiO2(AG) was much more effective on adsorbing soluble compounds, which could be analyzed by the hydrophobic and hydrophilic interaction theory between the adsorbent and adsorbate.Hydrophobic/hydrophilic SiO2(AG) adsorption performance for MB is superior to that for phenol, which could be explained via the electrostatic interaction theory.
Braucht Deutschland eine orthodoxe Religionspädagogik?
Authors: Danilovich Yauheniya 
Published: November 2019

Zusammenfassung
Die orthodoxe Kirche bildet mit ca. zwei Millionen Gläubigen die drittgrößte christliche Konfession in Deutschland. Orthodoxe Kinder und Jugendliche nehmen sowohl in den Gemeinden als auch in der Schule Angebote der orthodoxen religiösen Bildung wahr. Außerdem besuchen viele orthodoxe Kinder und Jugendliche den Religionsunterricht anderer christlicher Konfessionen. Diese Entwicklungen deuten auf einen Bedarf im Bereich der Lehreraus- und Fortbildung, der Konzipierung von Unterrichtsmaterialien und Schulbüchern und einer wissenschaftlichen Begleitung der religionspädagogischen Praxis hin. In dieser Hinsicht wird die Notwendigkeit einer wissenschaftlichen und strukturellen Etablierung der orthodoxen Religionspädagogik in Deutschland ersichtlich.
Eye Movements during Visuomotor Adaptation Represent Only Part of the Explicit Learning
Authors: Bromberg Zohar , Donchin Opher , Haar Shlomi 
Published: November 2019

AbstractVisuomotor rotations are learned through a combination of explicit strategy and implicit recalibration. However, measuring the relative contribution of each remains a challenge and the possibility of multiple explicit and implicit components complicates the issue. Recent interest has focused on the possibility that eye movements reflects explicit strategy. Here we compared eye movements during adaptation to two accepted measures of explicit learning: verbal report and the exclusion test. We found that while reporting, all subjects showed a match among all three measures. However, when subjects did not report their intention, the eye movements of some subjects suggested less explicit adaptation than what was measured in an exclusion test. Interestingly, subjects whose eye movements did match their exclusion could be clustered into the following two subgroups: fully implicit learners showing no evidence of explicit adaptation and explicit learners with little implicit adaptation. Subjects showing a mix of both explicit and implicit adaptation were also those where eye movements showed less explicit adaptation than did exclusion. Thus, our results support the idea of multiple components of explicit learning as only part of the explicit learning is reflected in the eye movements. Individual subjects may use explicit components that are reflected in the eyes or those that are not or some mixture of the two. Analysis of reaction times suggests that the explicit components reflected in the eye movements involve longer reaction times. This component, according to recent literature, may be related to mental rotation.
Biodiversity and Potential Use of Macro Algae in Pesisir Barat Lampung
Authors: Asih Triana , Khayuridlo Muhammad , Noor Rasuane , Muhfahroyin Muhfahroyin 
Published: November 2019

Pesisir Barat Regency in Lampung has abundant marine biological wealth that has not been widely known and utilized by the community, one of them is macro algae. The objectives of the research were to identify the types of macro algae and to explains the potential use of macro algae in the Pesisir Barat Lampung Region. The study used cruise method. The findings were identified by experts to validate the results of classification, morphology, and qualitative studies regarding the potential use and benefits of macro algae. From the results of this study, 15 species of macro algae were found on Tanjung Setia Beach included; 3 species of green algae (Chlorophyta) consist of Halimeda opuntia L., Caulerpa racemosa F., Ulva lactuca L .; 7 species of brown algae (Phaeophyta) consist of Padina pavonica L., Padina australis H., Sargassum vulgare C.A., Sargassum polycystum C.A., Turbinaria ornata J.A., Turbinaria ornata J.A., Fucus vesiculosus L.; and 5 species of red algae (Rhodophyta), consist of Corallina officinalis L., Gigartina pistilla S., Gigartina disticha S., Gracilaria verrucosa, H., Rhodymenia pseudopalmat J.V.L.The benefits of this research for society to provide insight into the potential use of macro algae which can be utilized in many fields. For students, provide information on the biodiversity of macro algae in the sea.
Uji Kinerja Surface Scanner 3D Menggunakan Sensor VL53L0X dan Mikrokontroler ATMEGA8535
Authors: Maria Putut Son , Susianti Elva 
Published: November 2019

Digital data recording of the geometry of 3-dimensional objects require a 3D scanner tool which are mostly using an imagery sensor. However there is hardly used information of scanned result, named color. Imagery sensor requires high spesification processing unit as capable as a personal computer for data acquisition processing. This research aims to build a 3D surface scanner using a time of flight laser ranging sensor and to develop its simple function to become more valuable device. Using point to point displacement method, the sensor measures the distance between the outermost point of the object and the sensor surface perpendicularly, once when one measurement is done then the object to be rotated along with the rotary table. The prototype was built using the VL53L0X sensor and ATMEGA8535 microcontroller as a motor controller for rotary table and vertical axis. Scanned data is sent from the microcontroller to the computer to be visualized in real time. The results show that the VL53L0X sensor is suitable for scanning convex objects but it is not capable to handle objects with multiple cavities.
Metode Resiprokal Dalam Pembelajaran Hitting Permainan Softball
Authors: Irsyada Roas , Rumini Rumini , Aji Putra Ranu Baskora 
Published: November 2019

ABSTRAK Perlunya metode pembelajaran resiprokal dalam penguasaan teknik dasar memukul agar kemampuan memukul dapat lebih spesifik dalam melakukan evaluasi karena terdapatnya observer. Penelitian ini merupakan penelitian terapan dengan analisis data yang digunakan dalam penelitian ini adalah analisis logis yang bersifat deskriptif kuantitatif. Hasil penelitian menunjukkan bahwa terjadi ketuntasan belajar mahasiswa pada materi hitting softball dengan nilai rata-rata kelas 80 dan tingkat kesesuain teknik gerakan adalah 4.05 dengan kategori sangat sesuai. Kata kunci: resiprokal, hitting, softball ABSTRACT The need for reciprocal learning methods in mastering the basic techniques of hitting so that the ability to hit can be more specific in conducting evaluations because of the presence of observers. This research is an applied research with data analysis used in this study is a descriptive quantitative analysis. The results showed that the learning completeness of students in softball hitting material with an average grade of 80 and the level of conformity of movement techniques was 4.05 with a very suitable category Keyword : reciprocal, hitting, softball
Propuesta para la inserción laboral de docentes en contextos de alta vulnerabilidad social
Authors: Gutiérrez Gutiérrez Magally , Vindas Cordero Montserrat 
Published: November 2019

Recibido 05 de mayo de 2010 • Aceptado 31 de agosto de 2010 • Corregido 29 de agosto de 2011

Este artículo tiene como objetivo socializar una propuesta de inserción laboral de docentes en contextos de alta vulnerabilidad social3, producto de la investigación realizada en una escuela de atención prioritaria del cantón central de Heredia4, en la cual se exploró el proceso de inserción laboral que se desarrolla con los docentes, con la intención de que estos respondan a la realidad comunal, familiar y estudiantil de una población inmersa en una dinámica de riesgo social. La investigación que sustenta la propuesta parte de un enfoque cualitativo, ya que el proceso de diagnóstico no pretende dar respuestas generalizables a otros centros educativos en contextos similares, sino lograr una aproximación exploratoria a la realidad docente y a su proceso de inserción en instituciones con alta vulnerabilidad social. Por tanto, el artículo, si bien plantea la intención de compartir esta experiencia, no pretende unificar prácticas de inserción, sino más bien ser un insumo en la realización de procesos similares.
(3) Entendiéndose como contexto de alta vulnerabilidad social el planteamiento realizado por Sojo (2003) que lo define como comunidades urbano marginales situadas en zonas catalogadas por el gobierno costarricense como de atención prioritaria, las cuales presentan el mayor atraso social y económico del país, con altos índices de violencia, ocio, desempleo y drogadicción.
(4) La institución educativa es de carácter público, y pertenece al Circuito 02 de esta Provincia.
¿Equidad de género en la enseñanza de las Matemáticas?
Authors: Gamboa Araya Ronny 
Published: November 2019

Recibido 02 de setiembre de 2011 • Aceptado 23 de febrero de 2012 • Corregido 21 de marzo de 2012 La enseñanza de las Matemáticas se ha visto influenciada por la presencia de ciertos estereotipos que han determinado el comportamiento y afectado el rendimiento del estudiantado en dicha disciplina. Diversas investigaciones han señalado la relación de inequidad que hombres y mujeres poseen respecto a las matemáticas y la responsabilidad que el profesorado tiene en su construcción. Por tal motivo se plantea la necesidad de llevar a cabo acciones concretas que permitan la construcción de relaciones de equidad en dicha disciplina, basadas en los principios de respeto, solidaridad y ayuda mutua entre los géneros.
Dimensión político-ideológica de la discapacidad: Un análisis desde el enfoque socio-crítico
Authors: Vargas Dengo Marie Claire 
Published: November 2019

Recibido 10 de noviembre de 2011 • Corregido 22 de mayo de 2012 • Aceptado 28 de junio de 2012 Desde el enfoque socio-crítico, se analiza la dimensión política e ideológica de la discapacidad con el fin de identificar procesos estructurales subyacentes a las políticas educativas en materia de discapacidad. El artículo contrasta las ideas y posiciones de distintos autores, y expone la vigencia y relevancia del tema para promover la inclusión educativa en la educación superior.
ETIOLOGICAL FACTORS AND CLINICAL PROFILE OF ACUTE KIDNEY INJURY IN MICU
Authors: Mathew Mekha K , Radha  
Published: November 2019

Background and Objectives
Data on the etiology, management practices and outcome in patients admitted to intensive care units in Kerala has not been studied in depth. The etiology and patterns of AKI, as well as management practices are likely to differ in countries with resource limitations and variations in disease patterns. The present study was undertaken to identify the etiologic factors and outcome of patients with Acute Kidney Injury admitted in Medical ICU.
Methods
The study is a cross sectional study, done in 150 consecutive patients admitted to Medical Intensive Care Unit, Government Medical College, Kottayam meeting the AKIN creatinine criteria for acute kidney injury over a period of 12 months.
Results and Discussion
The most common diagnosis in the patients admitted with AKI in MICU was Leptospirosis (22%) followed by undifferentiated fever (21%) and sepsis seen in 17%. Dialysis was required in 81.3% among those with undifferentiated febrile illness and 78.8% among those with leptospirosis. Significant association was identified between etiology of AKI and the need for dialysis. The most common stage of AKI in the patients in this study group on admission to the medical intensive care unit was stage 3 in 64.7%. 45% of the patients required dialysis, among which 24% underwent CRRT while the 76% underwent hemodialysis.
Out of 150 cases 59% survived and 41% expired. Mortality was more in the patients in this study with undifferentiated acute febrile illness, 43.8% and leptospirosis, 36.4%. Mortality was 48.5% in those who underwent dialysis. But no significant association was identified between requirement of dialysis or diagnosis and mortality. Significant association was identified between patients with breathlessness, basal crepitations, later stage of AKI, inotropic support, ventilator support and mortality with p value <0.05.
By logistic regression analysis of the factors having association with mortality, requirement of ventilator support and inotropic supports were independent predictors of mortality.
Conclusion
The most common etiology was leptospirosis (22%) followed by undifferentiated fever (21%). Mortality was 41% in the patients in the study group. Requirement of ventilator support and inotropic supports were independent predictors of mortality.