bluuebunny/crossref_metadata_2025_split huggingface dataset:
Positive node‐ratio in curative‐intent treatment for gastric cancer is a strong independent prognostic factor for 5‐year overall survival
Authors: Wohnrath Durval R. , Araujo Raphael L. C. 
Published: November 2019

AbstractIntroductionThis study addressed whether the positive node‐ratio (N‐ratio) for patients who underwent curative‐intent treatment was an independent prognostic factor of overall survival (OS) for gastric adenocarcinoma (GA).MethodsConsecutive patients who underwent gastrectomy for GA with at least 15 harvested nodes were evaluated for 5‐year OS. The best threshold was determined using the area under an receiver operating characteristic (ROC) curve. Univariate and multivariate models were assessed looking for independent prognostic factors for OS.ResultsFrom 1994 to 2015, 398 consecutive patients were evaluated. The N‐ratio ≥11% had an accuracy of 0.764, the sensitivity of 71.1%, the specificity of 81.7%, positive predictive value (PPV) of 91.7%, and odds ratio (OR) of 11. After multivariate analysis for OS, age ≥70 years (HR 1.44), need for total gastrectomy (HR 1.45), need for extended resection (HR 1.7), and N‐ratio ≥11% (HR 3.7) were unfavorable prognostic factors. D2 lymphadenectomy (HR 0.53) was a protective factor. The median OS according to N‐ratio was 14 months for N‐ratio >11 vs 58 months for N‐ratio <11%.ConclusionThe N‐ratio ≥11% was an independent negative prognostic factor for patients who underwent treatment for GA with curative intent. The N‐ratio ≥11% presented high specificity, high PPV and high OR for risk of death for 5 years after surgery.
Optimizing Survival Predictions of Hypopharynx Cancer: Development of a Clinical Prediction Model
Authors: Arends Coralie R. , Petersen Japke F. , van der Noort Vincent , Timmermans Adriana J. , Leemans C. René , de Bree Remco , van den Brekel Michiel W.M. , Stuiver Martijn M. 
Published: November 2019

ObjectivesTo develop and validate a clinical prediction model (CPM) for survival in hypopharynx cancer, thereby aiming to improve individualized estimations of survival.MethodsRetrospective cohort study of hypopharynx cancer patients. We randomly split the cohort into a derivation and validation dataset. The model was fitted on the derivation dataset and validated on the validation dataset. We used a Cox's proportional hazard model and least absolute shrinkage and selection operator (LASSO) selection. Performance (discrimination and calibration) of the CPM was tested.ResultsThe final model consisted of gender, subsite, TNM classification, Adult Comorbidity Evaluation‐27 score (ACE27), body mass index (BMI), hemoglobin, albumin, and leukocyte count. Of these, TNM classification, ACE27, BMI, hemoglobin, and albumin had independent significant associations with survival. The C Statistic was 0.62 after validation. The model could significantly identify clinical risk groups.ConclusionsACE27, BMI, hemoglobin, and albumin are independent predictors of overall survival. The identification of high‐risk patients can be used in the counseling process and tailoring of treatment strategy or follow‐up.Level of Evidence4 Laryngoscope, 130:2166–2172, 2020
Treatment strategy of hilar and intraglandular stones in wharton's duct: A 12‐year experience
Authors: Zhao Ya‐Ning , Zhang Ya‐Qiong , Zhang Li‐Qi , Xie Xiao‐Yan , Liu Deng‐Gao , Yu Guang‐Yan 
Published: November 2019

Objectives/HypothesisTo suggest a strategy for transoral removal of hilar and intraparenchymal submandibular stones.Study DesignRetrospective case series.MethodsRetrospective evaluation was performed for 514 consecutive patients with hilar and intraparenchymal submandibular stones treated via endoscopy‐assisted surgery from January 2006 to June 2018. Three patients had bilateral stones. The stones were classified as: hilar (type I), posthilar (type II), intraparenchymal (type III), and multiple stones (type IV).ResultsThe affected glands included 311 with type I, 84 with type II, 65 with type III, and 57 with type IV stones. Stones were successfully removed in 478 glands (92.5%, 478/517). Main treatment techniques included hilum ductotomy in 311 glands, intraparenchymal ductotomy in 68, submandibulotomy in 14, intraductal retrieval in 74, and hilum ductotomy accompanied by intraductal retrieval in 11. At a mean 40‐months follow‐up of 478 successful cases, clinical outcomes were good in 425, fair in 27, and poor in 26 glands. Postoperative sialograms in 75 stone‐free patients were categorized as: type I, normal (n = 6); type II, ectasia or stenosis in the main duct and no persistent contrast on functional films (n = 44); type III, ectasia or stenosis in the main duct and mild contrast retention (n = 15); and type IV, poor shape of the main duct and evident contrast retention (n = 10). Postoperative sialometry of 32 patients revealed no significant differences of the gland function between the two sides.ConclusionsAppropriate use of various endoscopy‐assisted approaches helps preserve the gland and facilitates recovery of gland function in patients with different depths of hilo‐parenchymal submandibular stones.Level of Evidence4 Laryngoscope, 130:2360–2365, 2020
Attic retraction pockets: Classification system
Authors: Vijayendra H. , Mahajan Nilesh H. , Vijayendra Vinay , Ramdass Sangeetha 
Published: November 2019

IntroductionAlthough attic retractions have previously been classified into Grades 0 through IV, it is often not possible to assign attic retraction pockets into a single specific category. The present study describes an improved classification system based on otoscopic and endoscopic visualization of the retraction pocket fundus, the ossicular status in the attic, degree of scutal erosion, and the presence or absence of cholesteatoma.Materials and MethodsOne hundred and fifty‐four patients (200 ears) with different grades of attic retraction pockets who were seen by a tertiary referral otology center between August 2015 and July 2018 were selected for this study.ObservationsThe new classification system (Grades I, IIa, IIb, IIIa, IIIb, IIIc, IVa, IVb, IVc, and V) was applied to these retraction pockets. Pure tone audiometry was obtained.ResultsAll attic retraction pockets could be classified precisely using the new classification system. Forty‐four of 200 (22%) of ears showed Grade I Attic retraction, 18 ears showed Grade IIa (9%), 14 showed Grade IIb (7%), 28 showed Grade IIIa (14%), 12 showed IIIb (6%), 20 showed Grade IIIc (10%), 16 showed grade IVa (8%), 12 showed grade IVb (6%), 28 showed grade IVc (14%), and eight showed grade V (4%) attic retraction pockets.Grades I, IIa, IIb, IIIa, and IVa had no significant hearing loss. Average hearing loss was 42 dB and 52 dB in Grades IIIb and IIIc, 44 dB and 58 dB in Grades IVb and IVc, and 61 dB in Grade V.Level of Evidence5 Laryngoscope, 130: 2034–2039, 2020
Exploring multisensory place experiences through cruise blog analysis
Authors: Buzova Daniela , Cervera‐Taulet Amparo , Sanz‐Blas Silvia 
Published: November 2019

AbstractThe multisensory approach to understanding consumer behavior has received increasing attention as a factor shaping individuals’ perception, attitude, and behavior. However, previous studies have scarcely investigated the role of senses on destination experiences as places of consumption. The aim of the research is to uncover tourists’ meaningful multisensory place perceptions by analyzing cruise travel blogs. The study conducted a thematic content analysis of 248 blog entries on Mediterranean port of call experiences using the text analytics software Leximancer. The results show a convergence between visual, gustatory, olfactory, and haptic impressions, while auditory perceptions are scarce and refer mainly to the presence/absence of noise. Interestingly, unlike past multisensory studies that reported haptic perceptions as the least salient sensory dimension in tourist experiences, the research identified three haptic themes associated with cutaneous, hedonic‐elicited, and somatic touch. The research yields a threefold contribution: (a) It provides empirical evidence for the relevance of multisensory perceptions on tourists’ evaluation of place experiences; (b) a novel methodological approach to assessing sensory impressions is used by analyzing tourists’ freely written online narratives; and (c) the research broadens the scope of existing multisensory literature by assessing urban/coastal travel destination experiences.
Mineralized Supramolecular Hydrogels Bearing Tunable Thermo‐Responsiveness
Authors: Wang Yu , Wang Yiming , Wang Jie , Zhao Fang , Xu Zhi , Yuan Zhenyu , Niu Xiaofeng , Li Li , Bai Shengyu , Shi Yulin , Guo Xuhong 
Published: November 2019

AbstractAlthough a variety of biomimetic mineralized materials have been created in the lab, the vast majority of these manmade examples lack response to external stimuli. Here, mineralized supramolecular hydrogels with on‐demand thermo‐responsiveness that are formed by a simple, physical crosslinking between amorphous CaCO3 (ACC) nanoparticles and poly(acrylic acid) (PAA) are reported. Upon the addition of Na2CO3 solution into a mixture composed of PAA and CaCl2, amorphous ACC nanoparticles are formed in situ and simultaneously crosslinked by PAA chains, giving rise to the mineralized hydrogels. Interestingly, upon tuning the content of the formed ACC, hydrogels with different types of thermo‐responsiveness can be easily obtained, and the transparencies of the resulting hydrogels are dramatically changed during the temperature‐driven phase transitions. As an application, these thermo‐responsive mineralized hydrogels are used to control the exposure of UV light, which is successfully applied to switch fluorescent signals in response to temperature.
LCP1 triggers mTORC2/AKT activity and is pharmacologically targeted by enzastaurin in hypereosinophilia
Authors: Ma Guangxin , Gezer Deniz , Herrmann Oliver , Feldberg Kristina , Schemionek Mirle , Jawhar Mohamad , Reiter Andreas , Brümmendorf Tim H. , Koschmieder Steffen , Chatain Nicolas 
Published: November 2019

AbstractHypereosinophilia (HE) is caused by a variety of disorders, ranging from parasite infections to autoimmune diseases and cancer. Only a small proportion of HE cases are clonal malignancies, and one of these, the group of eosinophilia‐associated tyrosine kinase fusion‐driven neoplasms, is sensitive to tyrosine kinase inhibitors, while most subtypes lack specific treatment. Eosinophil functions are highly dependent on actin polymerization, promoting priming, shape change, and infiltration of inflamed tissues. Therefore, we investigated the role of the actin‐binding protein lymphocyte cytosolic protein 1 (LCP1) in malignant and nonmalignant eosinophil differentiation. We use the protein kinase C‐β (PKCβ) selective inhibitor enzastaurin (Enza) to dephosphorylate and inactivate LCP1 in FIP1L1‐platelet‐derived growth factor receptor α (PDGFRA)‐positive Eol‐1 cells, and this was associated with reduced proliferation, metabolic activity, and colony formation as well as enhanced apoptosis and impaired migration. While Enza did not alter FIP1L1‐PDGFRA‐induced signal transducer and activator of transcription 3 (STAT3), STAT5, and ERK1/2 phosphorylation, it inhibited STAT1Tyr701 and AKTSer473 (but not AKTThr308) phosphorylation, and short hairpin RNA knockdown experiments confirmed that this process was mediated by LCP1 and associated mammalian target of rapamycin complex 2 (mTORC2) activity loss. Homeobox protein HoxB8 immortalized murine bone marrow cells showed impaired eosinophilic differentiation upon Enza treatment or LCP1 knockdown. Furthermore, Enza treatment of primary HE samples reduced eosinophil differentiation and survival. In conclusion, our data show that HE involves active LCP1, which interacts with mTOR and triggers mTORC2 activity, and that the PKCβ inhibitor Enza as well as targeting of LCP1 may provide a novel treatment approach to hypereosinophilic disorders.
Hybrid molecules with potential in vitro antiplasmodial and in vivo antimalarial activity against drug‐resistant Plasmodium falciparum
Authors: Feng Lian‐Shun , Xu Zhi , Chang Le , Li Chuan , Yan Xiao‐Fei , Gao Chuan , Ding Chao , Zhao Feng , Shi Feng , Wu Xiang 
Published: November 2019

AbstractMalaria is a tropical disease, leading to around half a million deaths annually. Antimalarials such as quinolines are crucial to fight against malaria, but malaria control is extremely challenged by the limited pipeline of effective pharmaceuticals against drug‐resistant strains of Plasmodium falciparum which are resistant toward almost all currently accessible antimalarials. To tackle the growing resistance, new antimalarial drugs are needed urgently. Hybrid molecules which contain two or more pharmacophores have the potential to overcome the drug resistance, and hybridization of quinoline privileged antimalarial building block with other antimalarial pharmacophores may provide novel molecules with enhanced in vitro and in vivo activity against drug‐resistant (including multidrug‐resistant) P falciparum. In recent years, numerous of quinoline hybrids were developed, and their activities against a panel of drug‐resistant P falciparum strains were screened. Some of quinoline hybrids were found to possess promising in vitro and in vivo potency. This review emphasized quinoline hybrid molecules with potential in vitro antiplasmodial and in vivo antimalarial activity against drug‐resistant P falciparum, covering articles published between 2010 and 2019.
The examination and modeling of moisture content effect of banana leaves on dielectric constant for remote sensing
Authors: Basyigit Ibrahim Bahadir 
Published: November 2019

AbstractRemote sensing technology is useful for detecting agricultural and fruit regions. In this way, the world map can be determined in terms of the vegetation canopy. Contrary to this case, the vegetation canopies can also be used in areas such as intelligence and military regions that are required to be hidden and invisible. The use of microwave remote sensing technology is more sensitive to radiation than other methods, so it allows us to have knowledge about the volumetric information of the target object. However, this method is based on obtaining the dielectric properties of the samples. The aim of this paper is to examine the effect of the moisture content on relative dielectric constant and dielectric loss of banana leaves at X‐band as a novelty. In this study, transmission line technique is used to measure dielectric properties of the samples (banana leaves) in 8.2 to 12.4 GHz. The initial natural moisture content of the fresh banana leaves before drying is calculated to be approximately 82%. The moisture content of the banana leaves is dried from about 82% to 40%. As a result, the relative dielectric constant of it decreases with increasing frequency. In addition, increased moisture content increases both real and imaginary parts of dielectric constant. Correspondingly, unlike literature, a model that calculates the relative dielectric constant and dielectric loss value of the banana leaves is obtained. Root mean square error (RMSE) and R‐squared (R2) are calculated to see regression performance of the proposed model.
Elliptical monopole based super wideband fractal antenna
Authors: Singhal Sarthak , Jaiverdhan  , Singh Amit K. 
Published: November 2019

AbstractAn elliptical monopole based third iterative fractal antenna for super wideband applications is investigated in this article. It consists of microstrip line fed three iterations of elliptical monopole in tree shaped manner and modified semielliptical ground plane. It has an impedance bandwidth of 0.65 to 35.61 GHz, that is, ratio bandwidth of 54.78:1. The overall footprint of the antenna is 170 × 150 mm2. A peak realized gain of 6.51 dB with an average gain of 3.24 dB is achieved. The investigated antenna has advantages of miniaturized dimensions, simple geometry, and wider bandwidth over previously reported structures.
Reisolation and NMR characterization of the satratoxins G and H
Authors: Hudson Daniel , Singh A. Jonathan , Lewis Andrew R. , Sulyok Michael , Hinkley Simon F.R. 
Published: November 2019

AbstractThe exquisitely cytotoxic macrolides, satratoxins G and H, have been reisolated from a solvent extract of a rice culture inoculated with Stachybotrys chartarum to be used as high‐purity reference compounds for analytical analyses. Extensive chromatographic separation realized the compounds that were fully recharacterized in two solvents by 1D‐ and 2D‐NMR spectroscopy, revealing some discrepancies in the nuclear magnetic resonance (NMR) data as compared with the previously reported values found in the literature. Detailed spectra are provided in order to aid future identification and dereplication.
Porcine IVF embryo development and estrogen receptors are influenced by the concentration of percoll gradients during sperm selection
Authors: Ohlweiler Lain U. , Mezzalira Joana C. , Mezzalira Alceu 
Published: November 2019

AbstractThis study aimed to evaluate the effect of three different concentrations of discontinuous gradients of percoll (90/45, 80/40, and 70/35) in the outcome of porcine in vitro fertilization (IVF) and its influence on further embryo development and quality. Embryo viability was assessed by the expression of estrogen receptors (E2R) and cleaved caspase‐3 (CC3). The highest percoll concentration (90/45) resulted in the lowest embryo production (24.9%) in comparison with 80/40 (37.5%) and 70/35 (40.0%), with the production being similar between the two lowest concentrations. The hatching rate for 90/45 (26.2%) was lower than for 80/40 (45.5%), and both were similar to the Group 70/35 (32.9%). The hatched embryos from the concentration 90/45 showed the lowest proportion of E2R expression (3.6%), while the Groups 80/40 (22.6%) and 70/35 (39.3%) had a similar proportion of expression. The live embryos that did not hatch until Day 8 of culture presented a higher CC3 proportion for Group 90/45 (18.3%), in comparison with 80/40 (12.7%) and 70/35 (10.7%), with the latter two being similar. In conclusion, adjustments in percoll concentration used for sperm selection before porcine IVF can improve embryo production and competence for pregnancy recognition and establishment.
Towards the molecular origin of glutamate CEST (GluCEST) imaging in rat brain
Authors: Cui Jing , Zu Zhongliang 
Published: November 2019

PurposeChemical exchange saturation transfer (CEST) signals at 3 ppm acquired with high irradiation powers, termed GluCEST, have been suggested as an indicator of glutamate in neural systems. However, amines in proteins may also contribute to the GluCEST signal, but they have been ignored in previous studies. This study aims to investigate the molecular origins and specificity of GluCEST signal in rat brain.MethodsDialysis was used to selectively remove small molecules, such as glutamate and other metabolites, from tissue homogenates prepared from rat brain. This approach allowed the specific influence of proteins on GluCEST to be measured. Clean CEST effects were also quantified by a 2‐step analysis, which first used a fitting approach to quantify the asymmetric magnetization transfer effect and an inverse subtraction to remove it, and then combined an apparent exchange‐dependent relaxation method with asymmetric analysis to remove the direct water saturation andT1weighting.ResultsThe removal of glutamate and other small metabolites by dialysis decreases the GluCEST signal by approximately 24%, indicating that a major contributor to GluCEST in the brain is amines in proteins under our experimental conditions.ConclusionData from in vivo GluCEST measurements should be interpreted with caution, especially in disorders in which changes in the content or conformation of proteins are expected.
Strong correlation between standing cough test and 24‐hour pad weights in the evaluation of male stress urinary incontinence
Authors: Yi Yooni A. , Keith Christopher G. , Graziano Christopher E. , Davenport Michael T. , Bergeson Rachel L. , Christine Brian S. , Morey Allen F. 
Published: November 2019

AbstractAimsWe sought to compare in‐office physical exam findings via standing cough test (SCT) versus 24‐hour pad weights among men seeking treatment for postprostatectomy stress urinary incontinence (SUI).MethodsA retrospective review of a single surgeon database of incontinence procedures was performed. Documentation of SUI severity (grades 0‐4) was completed by SCT preoperatively utilizing the Male Stress Incontinence Grading Scale (MSIGS). All patients had pads per day (PPD) and 24‐hour pad weights obtained. We determined the Spearman's correlation coefficient between these variables.ResultsWe identified 104 men who underwent anti‐incontinence surgery (AdVance Sling or artificial urinary sphincter [AUS]). In the sling group (65 patients), nearly all (97%) had minimal incontinence with SCT (MSIGS = 0‐2). In the AUS group (39 patients), most patients (69%) had an MSIGS 3 or 4 with SCT. Spearman's coefficient between quantification of SCT and pad weight for the overall group was ρ = .68 (P < .0001) demonstrating a strong positive correlation. PPD was also strongly correlated with pad weight (ρ = .55, P < .0001). As seen previously, SCT and PPD were correlated (ρ = .47, P < .0001). In a multivariable model predicting pad weight, the effect of SCT was greater than PPD (β = 83 [54‐111], P < .0001 vs 45 [2169], P = .0004).ConclusionsSCT findings strongly correlate to 24‐hour pad weights in the evaluation of male SUI. The SCT shows promise as a rapid, reliable, noninvasive measure of SUI severity before anti‐incontinence surgery.
Knowledge, attitude, and practice instruments for urinary incontinence: A psychometric review
Authors: Lima Ribeiro Gabriela , Teixeira Moreira Vasconcelos Camila , Silva Gomes Maria Laura , Veras Firmiano Mariana Luisa , Oliveira Batista Oriá Mônica , Gomes Lopes Lia 
Published: November 2019

AbstractAimsTo analyze the psychometric properties of instruments measure knowledge and/or attitude and/or practice related to urinary incontinence (UI).MethodsThis review was conducted in September 2018 without restrictions regarding language and year of publication. Data sources: MEDLINE/PubMed, CINAHL, SCOPUS, PsycINFO, Web of Science, Cochrane, LILACS, and Google. The psychometric properties were evaluated using the COnsensus‐based Standards for the selection of health status Measurement INstruments and the Quality Criteria for Measurement Properties.ResultsA total of seven articles published between 1999 and 2018 were included. The evaluation of the psychometric properties showed that the majority of the instruments presented “excellent” or “good” methodological quality; however, the description of aspects related to the validation stages was inadequate in some studies, causing the quality of the results to be evaluated as “indeterminate” in some properties. This review cannot recommend any questionnaire without reservations; however, the Urinary Incontinence Scales and the Barriers Incontinence Care Seeking Questionnaire presented better evaluations, regarding both methodological quality and the quality of the results.ConclusionThis review provides a strategy to select the most suitable instrument to assess knowledge, attitude, and practice regarding UI, according to the psychometric properties, guiding their use by researchers in clinical practice.