bluuebunny/crossref_metadata_2025_split huggingface dataset:
Online vaccine-related information-seeking in mothers and HPV vaccine uptake in their daughters
Authors: Dib F , Mayaud P , Longfier L , Launay O 
Published: October 2020

Abstract

Background
There is widespread concern about online vaccine misinformation. The aim of this study was to investigate the association between seeking vaccine-related information on the Internet and HPV vaccination uptake.

Methods
Data were obtained from the 2015, 2016, 2017 and 2018 Vaccinoscopie® studies, a pluriannual web-based survey conducted on a nationally representative quota sample of mothers to monitor the dynamics of vaccine coverage, perception and attitudes towards vaccination in France. Mothers of girls aged 14-15 years were asked to state all vaccinations reported on the vaccinal pages of their child's healthcare records. We computed univariate and multivariate logistic regression models, with the outcome variable “HPV vaccination” defined as equal to 1 if the daughter received at least one dose of HPV vaccine, and equal to 0 otherwise; and the dependant variable “Internet use” defined as equal to 1 if the mother responded “Internet” (alone or combined with other sources) to the question “When in doubt about a vaccine, what source(s) of information do you turn to to decide whether or not to have your child vaccinated?”, and equal to 0 otherwise.

Results
Over the 4 years, a total of 2038 mothers answered the self-administered online questionnaire. Overall, 96.1% declared their need to search for information, 23.9% of whom used the Internet as a source. Maternal Internet use was associated with lower HPV vaccination uptake in their daughters (Odds Ratio (OR)=0.49, 95%CI: 0.38-0.64). The association remained after adjusting for several potential confounders, including area of residence, household socio-professional category and income, maternal level of education, physician recommendation and use of other sources of information (adjusted OR = 0.68, 95%CI: 0.48-0.96).

Conclusions
Specific information campaigns are required to empower parents to better use online information and guide them to reputable sources when they seek information on vaccination.

Key messages
The findings of this study suggest that the use of online sources on information is negatively associated with HPV vaccination. Action is warranted to direct parents to use more correct online sources of information on vaccination.
Safety of in-neonatal intensive care unit administration of rotavirus vaccination among preterms
Authors: Costantino C , Restivo V , Tramuto F , Casuccio A , Palermo M , Vitale F 
Published: October 2020

Abstract

Background
Rotavirus is among the most common vaccine preventable illness in children under 5 years old. Despite increased severity of rotaviral illness in early infancy, most neonatal intensive care units (NICUs) do not administer rotavirus vaccination. The present project aims to evaluate the safety of in-neonatal intenive care unit administration of the monovalent live, attenuated rotavirus vaccination to preterm newborns in Sicily.

Methods
From the first of March 2018 within the six most important NICUs of Sicily (three located in Palermo, two in Catania and one in Messina), and under the scientific coordination of the University of Palermo and of the Regional Health Department, rotavirus vaccination was administered to preterm newborns with gestational age ≥28 weeks. Vaccine administrations were performed both under hospital and outpatient settings, from 6 weeks of age and in accordance with the Sicilian Vaccination Schedule.

Results
At the end of December 2019, 449 preterm newborns were fully vaccinated (two dose completion) against rotavirus in the six Sicilian NICUs participating to the project. Average gestational age was 31.4 (SD ± 2.7) weeks. First dose of rotavirus vaccination was administered at 6.3 (SD ± 0.6) weeks. Average weight at first dose were 2.890 (SD ± 0.456) grams. Only 8% and 2% of vaccinated newborns reported abdominal colic and fever &gt;38.5 °C in the 15 days after first dose, respectively. No one expected adverse event was observed in the 30 days after vaccination.

Conclusions
First data obtained from this study confirms the absolute safety of monovalent rotavirus vaccination also in preterm newborns with gestational age ≥28 weeks. Results could represent for public health physicians and for neonatologists a key tool for standardize rotavirus vaccination in very Italian NICU.

Key messages
Rotavirus vaccination is extremely safe in preterm newborns with gestational age ≥28 weeks. Rotavirus vaccination should be routinely implemented in Italian and European NICUs.
Rotavirus gastroenteritis hospitalization in children. Trends in Abruzzo Region, 2008-2018
Authors: D'Addezio M , Di Giovanni P , Cedrone F , Di Martino G , Masciarelli M , Meo F , Scampoli P , Staniscia T 
Published: October 2020

Abstract

Background
Rotavirus is the most important cause of hospitalization for gastroenteritis and dehydration in children under 5 years old. In developed countries, it significantly affects public health in terms of costs and morbidity. Despites the availability of an effective vaccine, the coverage remains low in Italy. This study aimed to evaluate the epidemiological impact of rotavirus hospitalizations in Abruzzo, an Italian region, from 2008 to 2018.

Methods
Data were obtained from hospital discharge records of all Abruzzo hospitals. For the study, only the admissions due to rotavirus infection occurring in children aged 0 to 5 over the study period were taken into consideration. For each year, age-adjusted standardized hospitalization rates for rotavirus infection were calculated, and time trends were analyzed by joint point regression models.

Results
A total of 747 admissions were identified. During the study period, a significant increase of admissions was observed among children under 1 year of age (AAPC +9.8%, 95%CI 0.0;20.5, p &lt; 0.001) and a significant decrease was observed among children between 2 and 3 years of age (AAPC -10.6%, 95%CI -20.0; -0.1, p &lt; 0.001). Overall, the standardized rate increased (AAPC +5.2%, 95%CI -3.0;14.1, p = 0.2).

Conclusions
These results confirm that Rotavirus gastroenteritis has a heavy impact on pediatric hospitalization in Abruzzo Region. Subsequently, the study gives evidence of the need to improve vaccination coverage, in order to reduce morbidity and costs for the Italian healthcare system.

Key messages
In Abruzzo region, rotavirus gastroenteritis is a very important cause of morbidity and hospitalization in children under 5 years old. This study confirms the need of an improvement in vaccination coverage, that is the most effective mean to reduce the high morbidity, as well as the social and health costs.
Adherence to the new WCRF cancer prevention recommendations associates with a decreased cancer risk
Authors: Deschasaux M , Bourhis L , Chazelas E , Debras C , Hercberg S , Latino-Martel P , Julia C , Kesse-Guyot E , Srour B , Touvier M 
Published: October 2020

Abstract

Background
Cancer remains one of the leading causes of death worldwide. In 2018, following its summary report, the World Cancer Research Fund (WCRF) issued its recommendations for cancer prevention based on the nutritional risk factors with a sufficient level of evidence. Our objective was to study whether adherence to these new recommendations leads to a reduced risk of cancer.

Methods
This study included 80,604 participants from the NutriNet-Santé population-based cohort study (2009-2019). Adherence to the 2018 WCRF recommendations was assessed using the operationalized score on a 7-point scale, proposed by Shams-White et al (Nutrients 2019), including: weight, physical activity, fruit and vegetables, dietary fibers, ultra-processed foods, red and processed meat, sugary drinks and alcohol. Usual dietary intakes were assessed using repeated 24h-dietary records and physical activity level using the IPAQ questionnaire. Multi-adjusted Cox proportional hazard models were used for the analyses.

Results
A total of 2,438 incident cancer cases were diagnosed during follow-up (median: 7.4 years). The median WCRF 2018 adherence score was 3.75 (IQR: 3.25-4.50). An increase of 1-point increment in the score was associated with a decreased risk of cancer overall (HR = 0.90; 95%CI 0.86-0.90; P&lt;.0001), and of obesity-related cancers (n = 1549 cases, HR = 0.89; 0.84-0.94; P&lt;.0001), aerodigestive cancers (n = 390, HR = 0.83; 0.74-0.93; P = 0.001), breast cancer (n = 749, HR = 0.92; 0.85-1.00; P = 0.04) and a non-significant trends for prostate (n = 332, HR = 0.89; 0.79-1.01; P = 0.07) and colorectal (n = 218, HR = 0.88; 0.76-1.03; P = 0.1) cancers.

Conclusions
Our results suggest that a higher adherence to the WCRF 2018 recommendations for cancer prevention is associated to a decreased risk of cancer. Given the consistency between overall food-based dietary guidelines and the WCRF cancer recommendations, our result support their general promotion to the general public and transposition as public health actions.

Key messages
Following the recommendations for cancer prevention issued by the WCRF in 2018 can contribute to decrease the burden of cancer. The WCRF cancer recommendations are consistent with overall food-based dietary guidelines and should be promoted to the general public and transposed as public health actions.
An exploration of cancer-related mortality attributable to infections in Italy
Authors: Ferrara P , Agüero F , Conti S , Masuet-Aumatell C , Mantovani L , Ramon-Torrell J M 
Published: October 2020

Abstract

Background
Previous attempts estimated the impact of infectious agents on cancer incidence in Italy, but the burden of carcinogenic infections on cancer mortality remains unknown. Therefore, we aimed to conduct a preliminary analysis in order to estimate this burden at country level.

Methods
We applied the global, regional, or national population attributable fractions for Helicobacter pylori, hepatitis B virus (HBV), hepatitis C virus (HCV), high-risk human papillomavirus (HPV) types, Epstein-Barr virus (EBV), human herpesvirus type 8 (HHV-8), and human T-cell lymphotropic virus type 1 (HTLV-1) - all microorganisms ranked as group 1 carcinogenic agents in human beings by the International Agency for Research on Cancer - to 2015 cancer-related deaths recorded according to the 10th International Classification of Diseases coding system in Italy.

Results
We estimated a total of 14,120 deaths attributable to carcinogenic infections, being 8.3% of the total of cancer-related deaths (n = 170,339). 58.8% of those occurred in men. H. pylori, HCV, HBC, and HPV accounted for 96.4% of the whole mortality burden attributable to carcinogenic infections in both sexes. H. pylori was responsible for 8,116 (57.5%) deaths due to gastric carcinoma (non-cardia and non-Hodgkin lymphoma). Hepatitis-related liver cancer accounted for a total 4,372 deaths: 3,812 due to HCV infection and 560 to HBV. Cancers related to HPV infection represented the third most frequent cause of deaths due to carcinogenic infections in women.

Conclusions
We estimated that one out of 12 cancer deaths in Italy was attributable to an infection sustained by carcinogenic agents. Such mortality burden is potentially avoidable, given that these infections are both potentially preventable and treatable. Thus, these estimates provide actionable metric of the burden for the implementation of specific public health measures. Further analyses will provide more accurate estimates of this disease burden.

Key messages
In Italy, one out of 12 cancer-related deaths is attributable to infections sustained by preventable or treatable carcinogenic agents. These estimates provide metric of carcinogenic infections for the implementation of specific public health measures to avert the related mortality burden.
Strategies to facilitate access to physical activity on a basic health unit: A participatory design
Authors: Cury de Carvalho A , Russo Rodrigues B , Maria Braga Edmundo K , Taiar R , Bittencourt Machado C 
Published: October 2020

Abstract

Background
sedentary lifestyle has been decreasing physical activity (PA) practice, accentuating the prevalence of overweight and obesity. Participatory methods in healthcare (including Design Thinking) have been proposed to obtain input from users, creating critical strategies for patients and physicians. The aim of this study was to elaborate strategies to facilitate access to PA for users from a basic health unit (BHU) by means of a participatory design.

Methods
a qualitative, participatory design with Design Thinking was carried out in a BHU at Nova Friburgo (Brazil), serving a community with 1,131 families. Semi-structured interviews were conducted with 32 users, and four health community agents (CHAs). Immersion and ideation (Design Thinking) were applied: (1) to gather information about PA; (2) to map free PA sites; (3) to develop generation sessions with users and CHAs, gathering information about needs, barriers and desires, and creating strategies to provide free PA.

Results
data showed that 59% of the users do not regularly practice PA. They reported lack of time, laziness, health problems, location and cost. CHAs said that they are not prepared to give information to users about PA. CHAs and users declared that they use mobile apps, and an app about PA would be helpful. According to them, the access for PA would be facilitated with: free offering, places near the community, CHA capacitation, professional advisement for exercise at home, and a mobile app with maps and transportation options, schedules, exercise programs and health education.

Conclusions
it was possible to propose strategies to facilitate access to PA by means of a participatory process (Design Thinking) with CHAs and HBU users. As a consequence, there is already a private financing support for a mobile app, as well as the preparation of a report to be presented to the city's secretary of health. It is expected to further benefit not only the local community, but the entire city.

Key messages
A participatory design with Design Thinking provided strategies to facilitate access to physical activity for users from a health basic unit. The development of a mobile app with information about PA access for underserved community seems to be an interesting option to foster exercise practice on a regular basis.
Mental health services utilization after Mariana dam burst
Authors: Dell'Aringa M F , Corrêa-Oliveira G E , Della Corte F , Ragazzoni L , Miranda E S , Murray V , Barone-Adesi F 
Published: October 2020

Abstract

Background
The global burden of mental health conditions is increasing, especially in middle- and low-income countries and frequently the quality of mental health services is lower than the quality of services for other conditions. Disasters may increase this burden through their direct impact or due to secondary stressors, such as the preclusion of access to essential services. The aim of this study is to assess the impact of Mariana dam burst (Brazil) in November 2015, in the utilization of public mental health services by the population that experienced an interruption of water supply after the event.

Methods
We used data from DATASUS, the database of the Brazilian public health system, analyzing data from 34 months before to 36 months after the event. We defined as affected the population living in the municipalities of Minas Gerais state that had an interruption of water supply after the event and the rest of the state population as the comparison group. We designed an Interrupted time-series analysis to evaluate both immediate and gradual changes in use of mental health services after the accident.

Results
The affected population included 381,749 inhabitants and the comparison group 20,487,352 inhabitants. The monthly rate of mental health visits in the affected population in the beginning of the series was 296 (CI 182 to 409, p &lt; 0.001) per 100.000 person-month. Comparing the groups after the event, we observed a non-statistically significant higher increase in the rate of visits immediately after the event of 115.96 (CI -30.00 to 261.92, p = 0.118) and a significant increase in the monthly rate of visits (change in slope) of 15.55 (CI 8.19 to 22.92, p &lt; 0.001) in the affected group.

Discussion
The results suggest that the event translated in a long-term increase in mental health services utilization. We believe that this study presents an innovative methodology on the assessment of mental health services after disasters and that it could be adapted to other contexts.

Key messages
Indirect impacts of disasters may be associated with long-term changes in the utilization of mental health services. Interrupted time series using routine data are useful tools for the assessment of health services utilization following disasters.
Implementing research and best practice for the development of community mental health facilities
Authors: Chrysikou E , Savvopoulou E , Cox E , Mc Frederick M 
Published: October 2020

Abstract
Healthcare is a sociotechnical system in which the technical system is interrelated to a social system of people and organization, including users, staff, carers, equipment, medication. Emphasis remaining on the latter, contributes to stigma. Outpatient services provide for the public health key components of early detection and support. This project was initiated by an NHS Mental Health Trust at a stage of building redevelopment. It aimed at gathering state of the art, best practice, innovative and challenging approaches on psychiatric buildings to inform an extensive multi-stakeholder and patient inclusive co-design process, useful for both the UK and other settings.
Research followed a qualitative methodology gathering data on best practice in community mental health facilities globally. First, a literature review was conducted with focus on built environment. Additionally, best practice case studies were analysed. In parallel, interviews with international experts were conducted. How can we incorporate out of the box design thinking, as a means to challenge the culture of psychiatric provision? How can we enable integration with non-psychiatric health systems and potentially inverse-integration practices? Data were evaluated using the SCP model, a tool developed for the evaluation of psychiatric buildings.
Results were organised under 32 key themes. These were further digested in two sections - the first comprising a set of design learnings and the second presenting visual material. Findings from the key themes were then organised in a matrix of design recommendations for wards and community mental health hubs to support patient, staff and community consultations with food for thought.
By treating design and place-making as a therapeutic tool we could challenge the way people view mental health buildings. Creating the means -review and inclusive consultation structure - to disrupt a normally segregated architectural dialogue - was essential to this process.

Key messages
Feedback methods for patient staff-consultation for capital planning: supporting staff and patients into the dialogue, increasing design and planning literacy. Evidence base, best practice and experimental design together for extracting meaningful feedback during capital planning consultation processes: we could learn from all three.
Engaging general population: Vaccine confidence, communication and mandatory law
Authors: Lopalco P L 
Published: October 2020

Abstract
Hesitancy is defined as the reluctance or refusal to be vaccinated even in case of vaccine availability and is included by the WHO among the top ten threats to global health. Vaccine confidence is an essential component of the hesitancy. Fear of adverse events and lack of trust in vaccine efficacy discourage the public and drive them toward the choice of refusal. Misinformation and lack of effective communication strategies may seriously jeopardize vaccination programmes. Providing effective communication requires specific competencies that often are not part of the common core competencies of those involved in vaccination programmes. In particular, the rapid evolution of the communication environment due to novel technologies makes the task even more difficult.
The general population in order to comply with the official vaccine recommendation throughout the life course is therefore a complex task. In the presence of worrying signals of lack of vaccine confidence, public health decision can be driven by emergency decisions rather than investing in mid-terms communication programmes. Vaccination mandates are public health measures that are proven to be effective in increasing vaccine uptake. Increasing anti-vaccine sentiment may be a potential negative trade-off. For this reason, the introduction of vaccination mandates should be combined with a structured communication strategy. In addition, vaccine sentiment should be actively monitored when any change in vaccine offer policy is implemented.
The impact of parental mental health and socioeconomic position on child preschool health
Authors: Heuckendorff S , Johansen M N , Overgaard C , Johnsen S P , Fonager K 
Published: October 2020

Abstract

Background
Many children, approximately one out of four to five, live in families with parental mental health problems. Knowledge on the impact of other mental health problems than depression or anxiety is sparse as well as the impact of the father. Therefore, we aimed to examine the effect of maternal and paternal mental health on child respiratory illness.

Methods
A population-based birth cohort study was conducted including all Danish children born from 2000-2012 using the Danish nationwide registers. Two follow-up periods were created: From age 1-2 and age 3-5. Mental health was categorised in three: No mental health problems, minor mental health condition if handled in solely primary healthcare; and moderate-severe if handled in psychiatric healthcare settings. Child respiratory illness was identified by prescribed medication or hospital-based diagnoses. Incidence rate ratios (IRR) were calculated using Poisson regression analysis.

Results
The analyses included 810,243 children. 26% of the mothers and 17% of the fathers were classified with mental health conditions. Children of parents with mental health conditions were more likely to have respiratory illness (10-12% vs. 7.7%). Adjusted IRRs revealed higher risks for children of mothers with minor (IRR 1.32 (CI95% 1.30-1.34)) and moderate-severe mental health conditions (IRR 1.48 (CI95% 1.44-1.51)). For paternal mental health, the IRRs were 1.14 (CI95% 1.12-1.16) for minor and IRR 1.14 (CI95% 1.11-1.17) for moderate-severe mental health conditions. The IRRs were a little higher for the children aged 1-2 years compared to 3-5-years.

Conclusions
Children of parents with mental health conditions were at greater risk of respiratory illness. This was evident for the mental health of both parents, most pronounced for the mother. Not only moderate-severe, but also minor mental health conditions increased the risk of respiratory illness.