bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Anti-Proliferative Evaluations of New Heterocyclic Derivatives Using 5,6,8,9-Tetrahydropyrazolo[5,1-b]quinazolin-7(3H)-one Derivatives Derived from Cyclohexa-1,4-dione
Authors: Mahmoud Mahmoud A.A. , Alsharif Meshari A. , Mohareb Rafat M. 
Published: May 2020

Background:
Recentlty, pyrazoloquinazoline derivatives acquired a special attention due to their
wide range of pharmacological activities, especially therapeutic. Through the market, it was found that many
pharmacological drugs containing the quinazoline nucleus were known.

Objective:
We are aiming in this work to synthesize target molecules not only possess anti-tumor
activities but also kinase inhibitors. The target molecules were obtained through the synthesis of a
series of 5,6,8,9-tetrahydropyrazolo[5,1-b]quinazolin-7(3H)-one derivatives 4a-i using the multicomponent reactions of cyclohexan-1,4-dione (1), the 5-amino-4-(2-arylhydrazono)-4H-pyrazol-3-ol
derivatives 2a-c the aromatic aldehydes 3a-c, respectively. The synthesized compounds were
evaluated against c-Met kinase, PC-3 cell line and different kinds of cancer cell lines together with
normal cell line, tyrosine kinases and Pim-1 kinase.

Methods:
Multi-component reactions were adopted using compound 1 to get different 5,6,8,9-
tetrahydropyrazolo[5,1-b]quinazolin-7(3H)-one derivatives which underwent further heterocyclization reactions.
The c-Met kinase activity of all compounds was evaluated using Homogeneous Time-Resolved Fluorescence
(HTRF) assay, taking foretinib as the positive control. The anti-proliferative activity of all target compounds
against the human prostatic cancer PC-3 cell line was measured using MTT assay using SGI-1776 as the reference
drug. All the synthesized compounds were assessed for inhibitory activities against A549 (non-small cell
lung cancer), H460 (human lung cancer), HT-29 (human colon cancer), and MKN-45 (human gastric cancer)
cancer cell lines together with foretinib as the positive control by an MTT assay.

Results:
Antiproliferative evaluations and c-Met kinase, Pim-1 kinase inhibitions were performed for the synthesized
compounds, where the varieties of substituents through the aryl ring and the thiophene moiety afforded
compounds with high activities.

Conclusion:
The compounds with high antiproliferative activity were tested towards c-Met and the results
showed that compounds 4e, 4f, 4g, 4i, 6i, 6k, 6l, 8f, 8i, 10d, 10e, 10f, 10h, 12e, 12f, 12g, 12h, 12i, 14f, 14g, 14h,
and 14i were the most potent compounds. A further selection of compounds for the Pim-1 kinase inhibition activity
showed that compounds 4f, 6i, 6l, 8h, 8i, 8g, 10d, 12i, and 14f were the most active compounds to inhibit Pim-1.
Antimicrobial Resistance Profiling of Coagulase-Negative Staphylococci in a Referral Center in South Italy: A Surveillance Study
Authors: Nicolosi Daria , Cinà Diana , Di Naso Concettina , D’Angeli Floriana , Salmeri Mario , Genovese Carlo 
Published: May 2020

Background:
CoNS are part of the normal flora of the skin, upper respiratory tract and human intestine. CoNS are able to colonize host tissues or inert materials such as prosthetics, heart valves, pacemakers, and urinary and venous catheters. They can also internalize in host cells, thus eluding immune defenses and attack by antibiotics.

Objective:
In this study, we collected the epidemiological data and determined the antibiotic susceptibility of 828 CoNS, collected in Garibaldi Hospital (Catania, Italy) between January 2016 and October 2018.

Methods:
Strains were evaluated by determining the Minimum Inhibitory Concentration (MIC) using the broth microdilution method, according to the guidelines of the Clinical and Laboratory Standards Institute. The antibiotic sensitivity pattern of CoNS against eighteen antibiotics was determined.

Results:
For all the 828 clinical isolates, varying resistance rates were observed: ampicillin (87%), penicillin (86%), amoxicillin-clavulanate (71%), oxacillin (70%), erythromycin (69%), azithromycin (68%), levofloxacin (55%), ciprofloxacin (54%), gentamycin (47%), moxifloxacin (42%), trimethoprim-sulfamethoxazole (30%), clindamycin (28%), tetracycline (24%), rifampicin (20%), quinupristin-dalfopristin (synercid) (4%). No strains investigated demonstrated resistance to teicoplanin, vancomycin and linezolid.

Conclusion:
Our results highlight the importance of monitoring the evolution of CoNS resistance in order to implement control measures and reduce the risk of spread in the population.
Factors Related to Self-care in Patients with Type 2 Diabetes
Authors: Kong Seung-Yeon , Cho Mi-Kyoung 
Published: May 2020

Purpose:
The prevalence of diabetes and the personal and national burden from diabetes, a serious health issue around the globe, continues to increase. The purpose of this study was to identify factors influencing self-care among patients with type 2 diabetes.

Methods:
We conducted a cross-sectional descriptive survey of 118 outpatients with type 2 diabetes in national university hospital C in Korea. Data were collected from self-report questionnaires covering information on demographics, self-care, and self-efficacy. Additional data were collected from medical records including information on HbA1c, fasting blood glucose levels, and cholesterol levels. Collected data were analyzed using descriptive statistics, Pearson’s correlation coefficient, and multiple regression using SPSS/WIN version 22.0 software.

Results:
Factors affecting self-care were the following four: self-efficacy, HbA1c, occupation status, and smoking status. Higher engagement in self-care was associated with higher self-efficacy (β = .53, p < .001), lower HbA1c (β = -0.33, p < .001), unemployment (β = -0.20, p < .001), and non-smoking status (β = -0.15, p = .011). The regression model of self-care among the type 2 diabetes patients was statistically significant (F = 67.15, p < .001), and the explanatory power of the adjusted R2 was 69%.

Conclusion:
Type 2 diabetes patients with high self-efficacy and self-care scores showed good glycemic control. Therefore, this finding suggests that nursing interventions should be developed to enhance self-efficacy, which is the greatest influencing factor for self-care.
Lung Cancer and Radiological Imaging
Authors: Panunzio Annalori , Sartori Paolo 
Published: May 2020

Background:
Lung cancer is the neoplasm with the highest prevalence and mortality rates in
the world. Most patients with lung cancer that are symptomatic have hemoptysis, coughing, shortness
of breath, chest pain and persistent infections. Less than 10% of patients are asymptomatic when the
tumor is detected as an incidental finding.

Objective:
The present expert review aims to describe the use of radiological imaging modalities for
the diagnosis of lung cancer.

Methods:
Some papers were selected from the international literature, by using mainly Pubmed as a
source.

Results:
Chest x-ray (CXR) is the first investigation performed during the workup of suspected lung
cancer. In the absence of a rib erosion, CXR cannot distinguish between benign and malignant masses,
therefore computed tomography (CT) with contrast enhancement should be performed in order to obtain
a correct staging. Magnetic resonance imaging of the chest is considered a secondary approach as
the respiratory movement affects the overall results.

Conclusion:
Radiological imaging is essential for the management of patients affected by lung cancer.
Susceptibility to Localized Corrosion of ASTM F745 and UNS S32750 Stainless Steels Influence of pH and Cytotoxicity Evaluation
Authors: Gregorutti Ricardo W. , Grau Jorge E. , Castrogiovanni Daniel , Parisi Julieta , Reigosa Miguel , Elsner Cecilia I. 
Published: May 2020

Background:
Body fluids are highly corrosive as they contain chlorides and hydroxides
ions, as well as salts, bacteria, proteins and dissolved oxygen. The pH of the body is usually around
7.4, although this value can vary in a range of 4 to 9 after surgery or because of haematomas, inflammations
and infections. ASTM F745 (type 316L) stainless steel has been used for load bearing partial
and total joint replacements and post trauma reconstructive surgeries. However, long exposure to the
aggressive effect of chloride ion present in the human body, may increase the susceptibility to suffer
localized corrosion. Although UNS S32750 has greater corrosion resistance to chloride ion, its magnetic
characteristics inhibit its use in implantable devices. Nevertheless, this stainless steel could be used
in temporary implants and orthodontic appliances such as brackets, wire arches and bands, due to its high
resistance to corrosion, the greater mechanical resistance and the high capacity of plastic forming.

Objectives:
The objective was to evaluate the susceptibility to localized corrosion in simulated body
fluid, in the pH range of 4 to 9. Another objective was to evaluate the cytotoxicity of Cr and Ni present
in the chemical composition of both stainless steels. Cytocompatibility was also analysed by
seeding cells on the surfaces of both stainless steels.

Methods:
Cyclic polariation test was performed to evaluate the susceptibility to localized corrosion in
0.9 wt% NaCl aqueous solution, at pH between 4 and 9, maintained at 37°C. For cytotoxicity evaluation,
neutral red, MTT and collagen assays were performed using UMR-106 cell line. Cytocompatibility
was analysed by seeding UMR-106 cells on the surfaces of both stainless steels.

Results:
F745-SS was more susceptible to suffer localized corrosion than UNS S32750. Although it
showed a tendency to develop transpassive reactions at low pH, galvanostatic tests did not reveal the
onset of localized corrosion. The results from the cytotoxicity assays indicated that no adverse effects
were observed. UMR-106 osteoblastic cells showed high viability, however, a slight reduction in the
collagen production was observed. The cytocompatibility was also satisfactory, since the cells seeded
on the surfaces had adequate proliferation.

Conclusion:
F745-SS is more susceptible to suffer localized corrosion than UNS S32750 in the pH
range between 4 and 9. UNS S32750 showed an extensive passive region, however, transpassive reactions
were observed at lower pH. On the other hand, no cytotoxic effects were promoted by both stainless
steels, although a slight reduction in collagen production was observed. Cells seeded on F745-SS and
UNS S32750 surfaces had an acceptable proliferation, without evidence of changes in their morphology.
Coronavirus: Crónica de una zoonosis anunciada
Authors: Mattar Salim , González Tous Marco 
Published: May 2020

Desde hace algunos años el espacio editorial de la Revista MVZ Córdoba se ha orientado hacia el abordaje de temas de salud pública humana y animal bajo el concepto “One Health”. Hemos valorado y analizado artículos científicos, emitido opiniones, suscitado debates, propuestas de líneas de investigación y también hemos pronosticado y advertido de la llegada de nuevas enfermedades tanto al país como al continente
Response of <i>Nezara viridula</i> (Hemiptera: Pentatomidae) on Some Plant Crude Extracts
Authors: Asmanizar Asmanizar , Aldywaridha Aldywaridha , Sumantri Edy , Lubis Ratna Mauli 
Published: May 2020

Nezara viridula (Hemiptera: Pentatomidae) is an important pest of soybean crop in Indonesia mainly soy bean. The insect cause seed damaged and decreasing of seed quality and quantity. The research was conducted to evaluate the insecticidal potential plant crude extract on the mortality of Green Stink Bug, N. viridula. Plant crude extracts were used in this study extracted by Soxhlet extractor. The experiment was done as oral toxicity (stomach poison) by dipping the bean pod in the crude extract solution and fed to N. viridula adult. The concentrations were 0.5 and 0.25% (volume of extract/volume of solution, v/v). The crude extracts which caused mortality effect up to 90-100% were continued to find the LC50 value. The results revealed that N. viridula mortality was affected by crude extracts. Crude extract of Annona muricata seed, Alpinia galanga rhizome and Jatropha curcas seed, at 0.5 and 0.25% concentration showed insects mortality up to 97.5-100%. Whilst, crude extracts of Lamtana camara, Cymbopogon nardus leaf and clumb, and P. betle leaf caused insect mortality 47.50 to 55%. Probit analysis showed that J. curcas seed crude extract was highly toxic (LC50=0.005%) to N. viridula adult followed by A. galanga rhizome crude extract (LC50=0.022%) and A. muricata seed crude extract (LC50=0.031%). These crude extracts proved to be highly potent to control N. viridula. More studies are essential to test these crude extracts and it is potential application as botanical insecticides at screen house and field.
Identifikasi Karakter Morfologi dan Agronomi Penentu Kehampaan Malai Padi (<i>Oryza sativa</i> L.)
Authors: Widyaningtias Lidwina Arum Meta , Yudono Prapto , Supriyanta Supriyanta 
Published: May 2020

Karakter morfologi dan agronomi seperti jumlah gabah per malai banyak, daun lebar, daun tipis, daun mendatar, daun cepat luruh, serta berumur genjah merupakan karakter penentu kehampaan gabah pada malai Padi Tipe Baru (PTB). Kehampaan gabah pada malai disebabkan oleh faktor genetik dan lingkungan. Penelitian ini bertujuan mengidentifikasi karakter morfologi padi penyebab kehampaan malai. Dua puluh satu padi nomor aksesi padi ditanam di Pusat Inovasi Agro Teknologi (PIAT) Universitas Gadjah Mada (UGM) di Kalitirto, Berbah, Kabupaten Sleman, Daerah Istimewa Yogyakarta pada bulan Maret hingga Agustus 2018 menggunakan Rancangan Acak Kelompok Lengkap (RAKL) dengan tiga ulangan. Data pengamatan dianalisis dengan analysis of covariance (Ancova) dilanjutkan analisis korelasi dan analisis lintas (path analysis). Hasil penelitian mengatakan, kehampaan mampu mengurangi gabah isi sebesar 29.33%. Berdasarkan analisis korelasi karakter morfologi dan agronomi penyebab kehampaan malai antara lain panjang daun bendera, anakan produktif, kepadatan malai dan gabah isi. Karakter tersebut beragam secara genetik sehingga dapat digunakan sebagai kriteria seleksi menurunkan kehampaan. Aksesi nomor 91 atau Q hitam dan 23 atau UGM*2 memiliki kehampaan rendah masing-masing sebesar 9.68% dan 9.92%, sehingga dapat digunakan sebagai tetua persilangan untuk menurunkan kehampaan.
Pengurangan Penggunaan Pupuk Urea Melalui Pemanfaatan Tanaman Turi Mini (<i>Sesbania rostrata</i>) pada Budidaya Jagung Manis
Authors: Effendy Iqbal , Paiman Paiman , Marlina Neni 
Published: May 2020

The use of inorganic fertilizer in agriculture as well as on sweet corn cultivation is quite high. Inorganic fertilizer recommended for sweet corn is 35 kg urea ha-1, 150 kg TSP ha-1 and 150 kg KCl ha-1. Besides high prices, its difficult to find when needed. To overcome this, an experiment was carried out by utilizing TM plants for reducing urea input. This research was carried out in Air Kuti Village, South Lubuklinggau District I, Lubuklinggau City, South Sumatera Province with an altitude of 110 meters above sea level (ASL), from April to June 2017. The experiment was arranged out in a randomized completely block design (RCBD) factorial 4 x 3 and repeated three times. The first factor was treatment combination of inorganic N fertilizer (urea) and TM plants consisted 4 kinds i.e: 75% urea and 1 TM plant, 50% urea and 2 TM plants, 25% urea and 3 TM plants, and 0% urea and 4 TM plants. The second factor was a frequency of urea application consisted of 3 levels i.e: 1-time application 15 days after planted (15 DAP), 2 times application (15 and 30 DAP), and 3 times application (15, 30 and 45 DAP). The results showed that application of urea fertilizer dosage of 25% recommended (108,75 kg urea ha-1) combinated with 3 stem of TM plants produced the best growth and yield of sweet corn. The frequency of urea application 3 times produced the best growth and yield of sweet corn.
Aplicación de Learning Analytics y Educational Data Mining en una institución de educación superior en Colombia
Authors: Salazar Cardona Johnny Alexander , Triviño Arbelaez Jorge Iván 
Published: May 2020

Actualmente, los datos son un insumo clave para el crecimiento continuo de las organizaciones a partir de la toma de decisiones, logrado a través de la aplicación de procesos de descubrimiento de conocimiento, realizando sobre los datos un preprocesamiento, transformación y análisis. El campo académico no es ajeno a este tipo de aplicaciones, y es tendencia para el aprovechamiento de los datos generados diariamente de sus estudiantes, áreas administrativas y académicas para realizar procesos de mejora continua.
Las metodologías actuales proponen 2 directrices: Learning Analytics (LA) enfocado principalmente a procesos descriptivos y Educational Data Mining (EDM) para procesos predictivos, direccionando actividades ajustadas a este entorno para obtener resultados satisfactorios. Es por esto, que el presente artículo presenta la aplicación de estas 2 corrientes en una institución de educación superior, enfocado a datos sensibles de los estudiantes, que servirán de apoyo para altas directivas en la institución de educación superior.
#BoycottBlizzard: Capitalismo de Plataforma e a Colonização do Jogo
Authors: Falcão Thiago , Marques Daniel , Mussa Ivan 
Published: May 2020

Este artigo discute os mecanismos de governança e controle exercidos pela desenvolvedora de games Blizzard sobre seus jogadores e consumidores. Baseia-se na controvérsia que ocorreu entre a empresa e o jogador profissional Blitzchung, que se manifestou a favor dos protestos iniciados em Hong Kong em março de 2019. O atrito, além de despertar tensões entre consumidores e produtora, revela os métodos e dispositivos de dominação empregados pela empresa contra seus jogadores. Considerando a Blizzard como uma plataforma, analisamos as ferramentas enredadas pela corporação para manter suas engrenagens estáveis, que alavancam discussões a respeito da plataformização da sociedade e da superposição entre jogo e trabalho.
DERIVATIONAL AND INFLECTIONAL MORPHEME ANALYSIS ON THE SONG LYRICS OF LADY GAGA “A STAR IS BORN” ALBUM
Authors: Aprianti Ira Nur , Parmawati Aseptiana 
Published: May 2020

The tittle of this research is Affixes Analysis on the Song Lyrics of Lady Gaga “A Star is Born” Album. The method that used in this study is to analyst the lyrics of “A Star is Born” album and the technique that used to collect the data is analyzing technique that used is qualitative method. The purpose of this research is to identify and find out the farms of the affix of derivation and inflectional from the lyrics of “A Star is Born” album. Based on the analysis, it was found that many types of derivation and inflectional affix. The most dominant that found in the Lady Gaga album song is derivation affix. The result of this research, 14 data or 58,3% derivation affixes 10 data or 41,7%% that inflectional found in "A Stars is Born” album. Keywords: Morphology, Affixes, Derivational, Inflectional
MILLENNIAL LECTURERS’ ATTITUDES IN INCORPORATING THE ONLINE APPLICATION IN THE EFL CLASSROOM
Authors: Sari Angela Bayu Pertama , Brameswari Catharina , Haratikka Haya 
Published: May 2020

Millennial lecturers are considered to be proficient in teaching by making use of the technology in their classrooms. Nine millennial lecturers were involved in this study. It was carried out as qualitative research. The data collection technique was open-ended questionnaires then analyzed through thematic analysis. Three research questions were aimed to be examined. The first one was the investigation on the variety of the online applications used in the EFL classrooms; the second one was questioning about the lecturers’ attitudes in getting the benefits of online application, and the third one was observing the lecturers’ attitudes in overcoming the limitations that they found in incorporating the online application in the EFL classroom. The results showed that seventeen types of the online mobile application that were used by the nine millennial lecturers in this study. The millennial lecturers took advantage of the online applications by establishing communication, encouraging students’ self-study, improving the assessment, motivating the students, and improving the teaching instruction. Other result showed that they overcame the limitations of online mobile applications by giving more information and giving assignment to solve the learning management issues and also adjusting the learning when tools issues occur. Keywords: millennial, lecturer, online application, EFL
INVESTIGATING EARLY-CAREER TEACHERS’ ADAPTATION CHALLENGES: A CASE OF INDONESIAN EFL TEACHERS
Authors: Mahmud Yogi Saputra 
Published: May 2020

Teacher professional development has recently become a central focus in the Indonesian context, particularly after the implementation of the post-bachelor teacher professional education program or Pendidikan Profesi Guru (PPG) for both pre-service and in-service EFL teachers in 2013. However, studies reveal that the transition from teacher education programs to the initial teaching career at schools has been described as a challenging phase. Despite the growing attention of scholars in exploring beginning teachers’ challenges, studies focusing on the early-career Indonesian EFL teachers, particularly those who just completed the PPG program, are considered limited. Therefore, drawing on a qualitative case study with two beginning Indonesian secondary EFL teachers, this study aims to unravel the challenges during their first-year teaching experience at school after completing the PPG program. By thematically analysing the semi-structured interviews, this study indicated that the teachers experienced four significant challenges: 1) pedagogical (classroom management, lack of teaching resources, test-based learning atmosphere), 2) professional (complex self-identification), 3) social (maintaining rapport with senior teachers), and 4) personal (mood management). Despite having been trained professionally through the PPG program, the result suggested that the beginning teachers still faced considerable challenges during their initial endeavour as an English teacher at school. Pedagogical implications are discussed in terms of the need for continuous professional development for the newly certified teachers during their initial career at schools.
AN ANALYSIS OF STUDENTS’ INTEREST OF READING ENGLISH NOVEL IN FACULTY OF LETTERS MUSLIM NUSANTARA AL-WASHLIYAH UNIVERSITY
Authors: Tarihoran Rezky Khoirina , Dewi Ratna Sari 
Published: May 2020

This research was aimed to find out how the condition of students’ interest in reading English novels in Faculty of Letters, Muslim Nusantara University Al-Washliyah. As a student majoring in English Literature, reading novels is one of the activities that must be carried out because most of the subjects given are closely related to centrality, one of which is an English-language novel. This research was conducted at the fifth semester students of the Faculty of Literature at Muslim Nusantara University Al-Washliyah. This research used a qualitative descriptive method. The instruments used were observation and interviews. Based on the results of the study it was found that the condition of students’ interest of reading English novels in Faculty of Letters, Muslim Nusantara Al-Washliyah University is very poor. Keywords: Analysis, Reading, Novel
THE USE OF TRIADIC SEMANTIC MODEL TO ANALYZE A DOCUMENTARY MOVIE :LION KINGDOM EPISODE 1: PRIDE AND PUNISHMENT
Authors: Sugiharto Zeffi , Monata Windyana , Husnussalam Hendra 
Published: May 2020

Charles Sanders Pierce’s Triadic semantic model is a semiotic theory that analyze the signs according to the relationship of the represantament and the object. The semantic research on the documentary movie entitled Lion Kingdom, episode 1: Pride and Punishment shows that there are three signs used in the movie. (1) Icon signs, appears 3 times, (2) indexes signs (appears 17 times), and Symbols, appears 15 times. Keywords: semiotic, Charles Sanders Pierce’s, movie.