bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interdisciplinary model of patient care for groups at risk for malignant tumors of the skin
Authors: Ufimtseva M. A. , Shubina A. S. , Petkau V. V. , Struin N. L. , Emel'janov D. E. , Levchenko E. A. 
Published: October 2019

Introduction. Malignant skin tumors (MST) are an important interdisciplinary problem. Neoplasia data refer to tumors of apparent localization, therefore, they are found in the clinical practice of doctors of different profiles. The duration of the diagnostic period, as well as the prognosis, depends on the coordinated work of specialists.Aim. Development, implementation and evaluation of the effectiveness of an interdisciplinary model for managing patients at risk for malignant skin tumors.Materials and methods. A descriptive study included a study of the proportion of people at risk for developing MST, the nosological structure of the revealed MST among patients referred to the dermatological oncology room of the Sverdlovsk Regional Dermatovenerologic Dispensary for the period from 01.01.2016 to 31.12.2017 (total 3,275 patients), as well as 208 patients examined in the Sverdlovsk Regional Oncology Dispensary (SROD). The data of the “ONKOR” regional oncological information system were used.Results. An interdisciplinary model of managing patients at risk has been developed, including patient routing andtraining of specialists in various fields. As a result of the implementation of the model, 208 patients were examined, 208 of whom were diagnosed with skin cancer, 123 of whom had skin cancer, 11 cases of melanoma, Kaposi’s sarcoma in 2 cases, skin lymphomas in 4 patients, lymphosarcoma in 1 patient, amounted to 67.8% of the diagnoses of MST confirmed in the Sverdlovsk Regional Dermatovenerologic Dispensary of the Sverdlovsk Regional Oncology Dispensary. 9.6% of patients had dysplastic nevi, confirmed histologically. 1987 patients at risk of developing MST were taken under the dispensary observation by a dermatologist and venereologist.Conclusion. Тhe introduction of the algorithm of interdisciplinary interaction contributes to the improvement of the quality and accessibility of medical care to the population, the identification of patients at risk for the occurrence of MST, reducing the burden of non-core patients on oncology services.
Multicomponent wound coating in treatment of an experimental, purulent wound
Authors: Grigoryan A. Yu. , Bezhin A. I. , Pankrusheva T. A. , Sukovatykh B. S. , Chekmareva M. S. , Zhilyaeva L. V. 
Published: October 2019

Objectives. To substantiate the effectiveness of the wound coating developed by us, which combines broad-spectrum antimicrobial effect, sorption activity, analgesic effect and prolonged action on a purulent wound.Materials and methods. The material for the study was wound coating in the form of a film developed at Kursk State Medical University (Russian patent number 2605343). Experimental animals (Wistar rats) were divided into 2 groups (comparative and experimental) of 36 animals in each. In all the experimental animals a purulent wound was modeled according to the method proposed by P.I. Tolstikh. Local anesthetic activity was determined on rabbits of the Chinchilla breed (20 individuals in each group). In the course of the study, the following methods were used: microbiological method (identification of the areas of growth retardation and wound contamination), visual assessment of the wounds, planimetric method, pH evaluation of the wounds, and Renier’s technique (for determination of the anesthetic activity). The data were processed statistically, and the statistical significance of the differences was determined using the nonparametric Mann – Whitney test. The differences were considered statistically significant at p ≤ 0.05.Results. Before the experiment on animals, high efficacy of the developed film was proven for the most common test strains of microorganisms capable of causing wound infection, using the microbiological method of investigation. Using the Renier’s method, the ability of the film to provide a local anesthetic effect was demonstrated, which was significantly higher than that of the 2% lidocaine ointment. Following visual evaluation of the wound, it was found that purification and regeneration of the wounds occurred earlier in the animals from the experimental group. The speed of wound healing in the experimental group was 1.3 times higher at 1–3 days, whereas at 5–8 days the situation was reversed in favor of the comparison group. In addition, at day 8 wound contamination in the experimental group was 1.2 times lower than in the comparison group. According to the results of the pH evaluation, significant differences between the groups were noted at days 5, 8, 15. Approximation of pH values to those of intact skin also proved the effectiveness of using the developed film.Conclusion. The results of the conducted studies confirmed broad-spectrum antimicrobial activity of the developed film, its local anesthetic activity and efficacy in treatment of experimental purulent wounds, which allows to recommend it for further preclinical trials.
Ventilation and respiration mechanics in patients with chronic obstructive pulmonary disease in different body positions
Authors: Dish Al. Ju. , Dish An. Ju. , Ageeva T. S. , Karzilov A. L. , Teteneva A. V. , Kalacheva T. P. , Mesko P. E. , Mishustina E. L. , Zaytseva A. A. , Paraeva O. S. , Bespalova I. D. , Chernogoryuk G. E. 
Published: October 2019

The aimof this work was to study changes in mechanical lung properties in cases of COPD in general and in different zones depending on the body position.Materials and methods. The research was performed in 37 patients with chronic obstructive pulmonary disease (COPD) in the vertical and horizontal positions (VP and HP).Results. The analysis of integral respiration mechanics has revealed a reduction in dynamic lung compliance and an increase in total non-elastic lung resistance during expiration (TNRexp) in HP vs. VP. At the same time, despite the increase in TNRexp in HP, the total work of breathing did not increase. Unlike healthy individuals, the COPD patients were characterized by the absence of differences in regional mechanical properties in both VP and HP. There were no differences in the respiration mechanics of the left lung, and the zones of the right lung only differed in the parameters of regional non-elastic work of breathing (NWBr ) that was increasing from top downwards: the indicators of NWBr during expiration and NWBr in the lower zone were higher as opposed to those of the upper zone in VP. As for HP, NWBr during inspiration, NWBr during expiration and NWBr were higher.Conclusion. The data obtained contradict the prevailing opinion about an escalation in regional differences in ventilation and respiration mechanics under the influence of emerging focal and diffuse inflammatorysclerotic pathological changes in lungs and emphysema.
Pathomorphological features of conjunctival and scleral regeneration associated with intraoperative application of Cyclosporin A
Authors: Zhigalskaya T. A. , Krivosheina O. I. , Dzyman A. N. , Khlusov I. A. 
Published: October 2019

Purpose. In experiment in vivo to study the features of regeneration of the conjunctiva and sclera of rats after surgery with intraoperative application of a 0.05% Ciclosporin A.Materials and methods. Еxperimental animals (rats) (n = 48) were divided into the main group, including the subgroups a (n = 16) and b (n = 16) and the comparison group (n = 16). Performed a through cut of the conjunctiva and damage to the surface layers of the sclera one of the eyes of all animals. Further on the surgical trauma zone in the main group, the intraoperative application of the cytostatic was performed. In the subgroup a with a duration of 3 minutes, in the subgroup b – 6 minutes. In the comparison group a hemostatic sponge without a cytostatic was used intraoperatively.Results. In the comparison group postoperative period proceeds with a stereotyped dynamics of cell phase changes in damaged tissues. In the end the development of dense conjunctival-scleral fusion in the area of surgical trauma was noted. Intraoperative application of 0.05% Cyclosporine A leads to a slowing of regeneration, preventing formation of rough conjunctival-scleral scar.Conclusions. Intraoperative applications of 0.05% Cyclosporin A change the stereotyped dynamics of the inflammatory-reparative regeneration in the surgical intervention zone, inhibiting the migration of cells almost in 3 times and significantly (in 2 times) prolonging the duration of the macrophage phase. This causes a slowdown of reparative regeneration, prevents excessive scarring in the operating area.
Comparative evaluation of osteogenic activity and the effect on hematopoietic function of bone marrow of fractions of Saussurea controversa and Filipendula ulmaria extracts in experimental osteomyelitis
Authors: Avdeeva E. Yu. , Skorokhodova M. G. , Sukhodolo I. V. , Porokhova E. D. , Slizovsky G. V. , Mushtovatova L. S. , Reshetov Ya. E. , Ivanov S. D. , Belousov M. V. 
Published: October 2019

The aim of the work was to study the effect of fractions from Saussurea controversa and Мeadowsweet extracts on hemopoiesis and regeneration of bone tissue, which are the main target indicators in experimental osteomyelitis.Materials and methods. In the experiment we used butanol, water and element-organic fractions from the Saussurea controversa extract as well as ethyl acetate, butanol and water fractions from the Мeadowsweet extract, obtained by liquid extraction of the extracts from corresponding plants with the help of organic solvents. After modeling osteomyelitis of the right femur in rats and course treatment for 28 days, the state of bone marrow hemopoiesis was evaluated and morphological examination of the affected limb was performed.Results. The butanol fraction (at a dose of 10 mg/kg) containing flavonol glycosides, the water fraction (at a dose of 80 mg/kg) containing polysaccharides in its composition and the element-organic fraction (at a dose of 10 mg/kg) represented by organic calcium showed the highest osteogenic activity in the Saussurea controversa extract. The water fraction from the Meadowsweet extract (at a dose of 50 mg/kg) demonstrated pronounced hemopoietic activity due to stimulating erythro-, granulo- and lymphopoiesis in the bone marrow of rats with experimental osteomyelitis.
Sexual differences in the clinical features of antipsychotic-induced hyperprolactinemia in patients with schizophrenia
Authors: Kornetova E. G. , Tiguntsev V. V. , Kornetov A. N. , Goncharova A. A. , Lobacheva O. A. , Davydov A. A. , Khardikova S. A. , Ivanova S. A. , Semke A. V. 
Published: October 2019

The goal was to identify gender differences in the clinical features of antipsychotic-induced hyperprolactinemia in patients with schizophrenia.Materials and methods. 98 patients from the Department of Endogenous Disorders of the Research Institute of Mental Health Clinic in Tomsk were examined. Persons aged 18–50 were included with followup treatment for at least 1 year, whose condition corresponded to the ICD-10 schizophrenia criteria. Prolactin levels were determined by ELISA using the PRL Test System reagent kit (MonobindInc., USA). The base map of sociodemographic and clinical-dynamic features for patients with schizophrenia was used. Statistical processing of data was performed using the Statistica 12.0 software package. Mann–Whitney U test, Pearson’s χ² criterion, including Yates correction, and Fisher’s two-sided test were used for comparing small samples.Results. The average serum concentration of prolactin in women was 52.4 ± 39.1 ng/ml, in men it was 26.7 ± 19.7 ng/ml. Hyperprolactinemia was detected in 23 (47.9%) women and 25 (50%) men. Among women with hyperprolactinemia, statistically significant “Weight Gain” and “Headache” parameters were more common (p = 0.044 and p = 0.005, respectively). Men with hyperprolactinemia had higher BMI rates (p = 0.0066). For the rest of the UKU paragraphs, no significant differences were found in both men and women. Men presented fewer complaints and were less willing to discuss sexual dysfunction.Conclusion. Antipsychotic-induced hyperprolactinemia in patients with schizophrenia does not always have a full range of specific clinical manifestations and needs careful examination of patients with account of gender characteristics, as well as regular monitoring of the prolactin level in the serum of patients.
The influence of smoking on the formation of airway hyperresponsiveness to cold and the course of destructive-cytological processes in the goblet cells of the bronchial epithelium in patients with asthma
Authors: Pirogov A. B. , Prikhodko A. G. , Kolosov V. P. , Perelman Ju. M. 
Published: October 2019

Tobacco smoking in patients with asthma can intensify the bronchi mucosa damage and significantly worsen the course of the disease.Aim. To assess the influence of tobacco smoking on the clinical manifestations of the disease, airway response to cold air exposure and destructive-cytological processes in the goblet cells of bronchial epithelium in patients with asthma.Materials and methods. In 145 patients with asthma their asthma control level was determined by the Аsthma Control Test, lung function (FEV1 , %) and airway response (∆FEV1 , %) to a 3-minute isocapnic hyperventilation (–20 °С) of cold air (IHCA) were evaluated, and induced sputum (IS) was collected. In cytograms of IS a percentage content, the index of cell destruction (ICD) and the index of cytolysis intensiveness (IC) were assessed; histochemically the activity of myeloperoxidase (MPO) and the contents of glycoproteins were identified. The 1st group included 102 non-smokers and the 2nd group included 43 smokers.Results. In IS of patients of the 2nd group in comparison with the 1st one we found intensification of the destructive (ICD = 0.47 ± 0.02 and 0.40 ± 0.02, respectively, р = 0.044) and cytolytic activity of goblet cells (IC = 0.22 ± 0.03 and 0.15 ± 0.02, respectively, р = 0.047) with the domination of the number of completely destroyed cells (21.7 ± 2.4 vs. 14.5 ± 1.6%, р = 0.043) and the decrease in the number of cells with a normal structure (52.5 ± 2.1 vs. 60.5 ± 3.1%, р = 0.047). For smokers it was typical to have high contents of neutrophils in IS (34.1 ± 3.0 vs. 23.9 ± 1.4%, respectively, р = 0.0006) and high level of myeloperoxidase in granulocytes of bronchi (94.3 ± 5.4 vs. 80.7 ± 3.6 pixels, р = 0.037). Smokers responded more actively to IHCA (∆FEV1 was –13.7 ± 2.6 vs. –7.9 ± 1.2%, respectively, р = 0.032), and the degree of the response correlated with the indices of destructive-cytological activity of IS cells.Conclusion. Tobacco smoking in patients with asthma leads to the disturbance of the structure of goblet epithelium in the bronchi with the intensification of destructive-cytological processes, which is accompanied by a decrease in the level of glycoproteins in cytoplasm, an increase in the secretory activity of the goblet cells, neutrophilia, growth of oxidative peroxidase activity of granulocytes, worsening of the bronchial conductance, and intensification of airway response to cold air.
The TIFY Gene Family in Wheat and its Progenitors: Genome-wide Identification, Evolution and Expression Analysis
Authors: Xie Songfeng , Cui Licao , Lei Xiaole , Yang Guang , Li Jun , Nie Xiaojun , Ji Wanquan 
Published: October 2019

Background:
The TIFY gene family is a group of plant-specific proteins involved in the
jasmonate (JA) metabolic process, which plays a vital role in plant growth and development as well as
stress response. Although it has been extensively studied in many species, the significance of this family
is not well studied in wheat.

Objective:
To comprehensively understand the genome organization and evolution of TIFY family in
wheat, a genome-wide identification was performed in wheat and its two progenitors using updated
genome information provided here.

Results:
In total, 63, 13 and 17 TIFY proteins were identified in wheat, Triticum urartu and Aegilops
tauschii respectively. Phylogenetic analysis clustered them into 18 groups with 14 groups possessing
A, B and D copies in wheat, demonstrating the completion of the genome as well as the two rounds of
allopolyploidization events. Gene structure, conserved protein motif and cis-regulatory element divergence
of A, B, D homoeologous copies were also investigated to gain insight into the evolutionary
conservation and divergence of homoeologous genes. Furthermore, the expression profiles of the
genes were detected using the available RNA-seq and the expression of 4 drought-responsive candidates
was further validated through qRT-PCR analysis. Finally, the co-expression network was constructed
and a total of 22 nodes with 121 edges of gene pairs were found.

Conclusion:
This study systematically reported the characteristics of the wheat TIFY family, which
ultimately provided important targets for further functional analysis and also facilitated the elucidation
of the evolution mechanism of TIFY genes in wheat and more.
Stylistic analysis of charles lamb’s essay dream children-reverie
Authors: Ali Kainat , Fatima Shadab , Tarique Tarique , Chandio Rashid Ali 
Published: October 2019

The study has been designed to analyze a literary piece that is “Dream Children Reverie” written by Charles Lamb via stylistics. The stylistic study deals with linguistic, graphological, phonological, grammatical, syntactical and structural aspects of the essay. In the study, the text has been explicated via stylistics analysis of the literary devices and style in which the text has been composed of. The study excavates various literary devices from the essay like symbolism, imagery, humor, and pathos that provides ancillary support to the overall meaning and impact of the essay. The present paper is a comprehensive study of literary text via a linguistic perspective. In addition, the study is also useful to find out themes in the essay Dream Children Reverie and it ensures to depict the self-portraying nature of the composition.
Similarity Analyzer for Semantic Interoperability of Electronic Health Records Using Artificial Intelligence (AI)
Authors: Naveed Arjmand 
Published: October 2019

The introduction of Electronic Health Records (EHR) has opened possibilities for solving interoperability issues within the healthcare sector. However, even with the introduction of EHRs, healthcare systems like hospitals and pharmacies remain isolated with no sharing of EHRs due to semantic interoperability issues. This paper extends our previous work in which we proposed a framework that dealt with semantic interoperability and security of EHR. The extension is the proposal of a cloud-based similarity analyzer for data structuring, data mapping, data modeling and conflict removal using Word2vec Artificial Intelligence (AI) technique. Different types of conflicts are removed from data in order to model data into common data types which can be interpreted by different stakeholders.
ETHERIFICATION OF GLYCEROL AND BUTYL ALCOHOL USING SOLID CATALYST TO A PRODUCED GLYCEROL TERT-BUTYL ETHER (GTBE) (REVIEW OF THE EFFECT OF REACTION TIME AND THE NUMBER OF CATALYST ON THE SUCCESSED GTBE CONVERSION)
Authors: Chania Aulia 
Published: October 2019

Eterifikasi gliserol dan tert-butil alkohol dengan katalis Dowex50WX2 dilakukan dengan menggunakan reaktor batch. Parameter penelitian yang divariasikan yaitu waktu reaksi 3jam, 4jam, dan 5jam serta jumlah katalis dengan variasi 7, 8 dan 9% berat. Penelitian ini bertujuan untuk memodifikasi gliserol menjadi fuel additive, mengetahui pengaruh waktu reaksi dan jumlah katalis Dowex 50WX2 terhadap konversi GTBE yang dihasilkan, dan mengetahui sifat fisik dan sifat kimia produk gliserol tert-butil eter yang dihasilkan dari reaksi eterifikasi. Hasil penelitian ini menunjukkan bahwa konversi gliserol terendah diperoleh pada waktu rekasi 3 jamdan jumlah katalis 7% berat yaitu 96,8043% , serta konversi gliserol tertinggi diperoleh pada waktu reaksi 5 jam dan jumlah katalis 8% berat yaitu 98,0362%. sifat fisik dan sifat kimia produk berdasarkan analisis yang terlah dilakukan mendeskripsikan bahwa produk GTBE yang dihasilkan sesuai dengan standar fuel additive yang berlaku.
Usefulness of Cardiac Index to Predict Early and 30-Day Mortality in Non-Cardiac Patients Being Admitted to Intensive Care Units
Authors: Moradians Vahan , Moosavi Seyed Ali Javad , Niyakan Lahiji Mohammad , Izadi Maryam 
Published: October 2019

Introduction: Cardiac index is a hemodynamic parameter defined as the ratio of the cardiac output, i.e., the volume of blood ejected from the left ventricle in 1 min, to the body surface area. This study aimed to assess the cardiac index to predict early and 30-day outcomes of non-cardiac patients being admitted to intensive care units using a non-invasive approach.
Materials and Methods: This prospective cohort study included 31 non-cardiac patients who were consecutively admitted to the intensive care units of Rasoul-e-Akram Hospital, Tehran, Iran, in 2016. On admission, the simplified acute physiology score II to predict mortality and the cardiac output (by two-dimensional echocardiography) of each patient were determined. The cardiac index was calculated by dividing the cardiac output by the body surface area. In-hospital mortality and complications were assessed, and the association between simplified acute physiology score II and cardiac index was determined. The patients were followed-up 30 days after discharge by telephone to determine late death, occurrence of myocardial infarction, readmission, or re-hospitalization.
Results: The mean cardiac index was significantly lower among the patients who died in intensive care units than in those who survived (2.86 ± 0.63 versus 3.70 ± 0.49, p = 0.006). A significant inverse association was found between Simplified Acute Physiology Score II and cardiac index (r = −0.539, p = 0.002). The length of hospital and intensive care units stay was not associated with Simplified Acute Physiology Score -II or cardiac index. The receiver operating characteristic curve analysis revealed that the cardiac index was effective in predicting in intensive care units mortality (area under curve = 0.857, p = 0.007). The best cut-off value for the cardiac index to predict in intensive care units mortality was 3.35, yielding a sensitivity of 83.3% and a specificity of 80.0%.
Conclusion: Measuring the cardiac index during intensive care units admission using a noninvasive approach even in non-cardiac patients can predict in intensive care units mortality with high sensitivity and specificity.