bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whole Health Options and Pain Education (wHOPE): A Pragmatic Trial Comparing Whole Health Team vs Primary Care Group Education to Promote Nonpharmacological Strategies to Improve Pain, Functioning, and Quality of Life in Veterans—Rationale, Methods, and Implementation
Authors: Seal Karen H , Becker William C , Murphy Jennifer L , Purcell Natalie , Denneson Lauren M , Morasco Benjamin J , Martin Aaron M , Reddy Kavitha , Iseghem Theresa Van , Krebs Erin E , Painter Jacob M , Hagedorn Hildi , Pyne Jeffrey M , Hixon John , Maguen Shira , Neylan Thomas C , Borsari Brian , DeRonne Beth , Gibson Carolyn , Matthias Marianne S , Frank Joseph W , Krishnaswamy Akshaya , Li Yongmei , Bertenthal Daniel , Chan Allan , Nunez Alejandro , McCamish Nicole 
Published: November 2020

Abstract

Background
The Whole Health model of the U.S. Department of Veterans Affairs (VA) emphasizes holistic self-care and multimodal approaches to improve pain, functioning, and quality of life. wHOPE (Whole Health Options and Pain Education) seeks to be the first multisite pragmatic trial to establish evidence for the VA Whole Health model for chronic pain care.

Design
wHOPE is a pragmatic randomized controlled trial comparing a Whole Health Team (WHT) approach to Primary Care Group Education (PC-GE); both will be compared to Usual VA Primary Care (UPC). The WHT consists of a medical provider, a complementary and integrative health (CIH) provider, and a Whole Health coach, who collaborate with VA patients to create a Personalized Health Plan emphasizing CIH approaches to chronic pain management. The active comparator, PC-GE, is adapted group cognitive behavioral therapy for chronic pain. The first aim is to test whether the WHT approach is superior to PC-GE and whether both are superior to UPC in decreasing pain interference in functioning in 750 veterans with moderate to severe chronic pain (primary outcome). Secondary outcomes include changes in pain severity, quality of life, mental health symptoms, and use of nonpharmacological and pharmacological therapies for pain. Outcomes will be collected from the VA electronic health record and patient-reported data over 12 months of follow-up. Aim 2 consists of an implementation-focused process evaluation and budget impact analysis.

Summary
This trial is part of the Pain Management Collaboratory, which seeks to create national-level infrastructure to support evidence-based nonpharmacological pain management approaches for veterans and military service personnel.
AN INTERVENTIONAL CARDIOLOGY INVESTIGATION: PATIENT EXPOSURE TO RADIATION AND INTER-OPERATOR VARIABILITY IN AN IRISH SETTING
Authors: Anderson Joseph , Zanardo Moreno , Smyth Brian , Fox Lis , Anderson Ashna , Maher Marion , Louise Rainford L 
Published: November 2020

Abstract
Aim: To evaluate patient radiation exposure for Diagnostic Coronary Angiography (DCA) and Percutaneous Cardiac Intervention (PCI) performed by different operators. Methods and Results: Retrospective (n = 160) and prospective (n = 62) data for DCA (n = 179) and PCI (n = 43) examinations performed by interventional cardiologists (n = 3) using the same imaging equipment were reviewed. The operator with consistently low diagnostic reference levels (DRLs) was interviewed for their personal perceptions upon operator training. Retrospective Median [IQR] DAP was 18.8 [11.8–31.6] and 50.7 [35.3–85.6] Gy.cm2 for DCA and PCI, respectively. Prospective Median [IQR] DAP for DCA and PCI was 7.9 [5.2–10.6] and 15.9 [10.0–17.7] Gy.cm2, respectively. DRLs were within Irish and European DRLs; however, significant inter-operator variability (p &lt; .001) was identified. Conclusion: Radiation exposure in Interventional cardiology is highly operator dependent; further research is warranted in standardization of operator training with evolving technologies.
Self-stigma in Serious Mental Illness: A Systematic Review of Frequency, Correlates, and Consequences
Authors: Dubreucq Julien , Plasse Julien , Franck Nicolas 
Published: November 2020

Abstract
Self-stigma is associated with poor clinical and functional outcomes in Serious Mental Illness (SMI). There has been no review of self-stigma frequency and correlates in different cultural and geographic areas and SMI. The objectives of the present study were: (1) to review the frequency, correlates, and consequences of self-stigma in individuals with SMI; (2) to compare self-stigma in different geographical areas and to review its potential association with cultural factors; (3) to evaluate the strengths and limitations of the current body of evidence to guide future research. A systematic electronic database search (PubMed, Web of Science, PsycINFO, Scopus, and Ovid SP Cumulative Index to Nursing and Allied Health Literature [CINAHL]) following PRISMA guidelines, was conducted on the frequency, correlates, and consequences of self-stigma in SMI. Out of 272 articles, 80 (29.4%) reported on the frequency of self-stigma (n = 25 458), 241 (88.6%) on cross-sectional correlates of self-stigma and 41 (15.0%) on the longitudinal correlates and consequences of self-stigma. On average, 31.3% of SMI patients reported high self-stigma. The highest frequency was in South-East Asia (39.7%) and the Middle East (39%). Sociodemographic and illness-related predictors yielded mixed results. Perceived and experienced stigma—including from mental health providers—predicted self-stigma, which supports the need to develop anti-stigma campaigns and recovery-oriented practices. Increased transition to psychosis and poor clinical and functional outcomes are both associated with self-stigma. Psychiatric rehabilitation and recovery-oriented early interventions could reduce self-stigma and should be better integrated into public policy.
Phenotypic factors associated with lamb live weight and carcass composition measurements in an Irish multi-breed sheep population1
Authors: McGovern Fiona Mary , McHugh Noirin , Fitzmaurice Shauna , Pabiou Thierry , McDermott Kevin , Wall Eamon , Fetherstone Nicola 
Published: November 2020

Abstract
Understanding the phenotypic factors that affect lamb live weight and carcass composition is imperative to generating accurate genetic evaluations and further enables implementation of functional management strategies. This study investigated phenotypic factors affecting live weight across the growing season and traits associated with carcass composition in lambs from a multibreed sheep population. Four live weight traits and two carcass composition traits were considered for analysis namely; birth, preweaning, weaning, and postweaning weight, and ultrasound muscle depth and fat depth. A total of 427,927 records from 159,492 lambs collected from 775 flocks between the years 2016 and 2019, inclusive were available from the Irish national sheep database. Factors associated with live weight and carcass composition were determined using linear mixed models. The heaviest birth, preweaning, and weaning weights were associated with single born lambs (P &lt; 0.001), however by postweaning, there was no difference observed in the weights of single and twin born lambs (P &gt; 0.01). Breed class affected lamb live weight and carcass composition with terminal lambs weighing heaviest and having greater muscle depth than all other breed classes investigated (P &lt; 0.001). Lambs born to first parity dams were consistently lighter, regardless of time of weighing (P &lt; 0.001), while dams lambing for the first time as ewe lambs produced lighter lambs than those lambing for the first time as hoggets (P &lt; 0.001). Greater heterosis coefficients (i.e., &gt;90% and ≤100%) resulted in heavier lambs at weaning compared with lambs with lower levels of heterosis coefficients (P &lt; 0.001). A heterosis coefficient class &lt;10% resulted in lambs with greater muscle depth while recombination loss of &lt;10% increased ultrasound fat depth (P &lt; 0.001). Results from this study highlight the impact of multiple animal level factors on lamb live weight and carcass composition which will enable more accurate bio-economic models and genetic evaluations going forward.
Intrinsic non-stomatal resilience to drought of the photosynthetic apparatus in Coffea spp. is strengthened by elevated air [CO2]
Authors: Semedo José N , Rodrigues Ana P , Lidon Fernando C , Pais Isabel P , Marques Isabel , Gouveia Duarte , Armengaud Jean , Silva Maria J , Martins Sónia , Semedo Magda C , Dubberstein Danielly , Partelli Fábio L , Reboredo Fernando H , Scotti-Campos Paula , Ribeiro-Barros Ana I , DaMatta Fábio M , Ramalho José C 
Published: November 2020

Abstract
Growing water restrictions associated with climate changes constitute daunting challenges to crop performance. This study unveils the impacts of moderate (MWD) or severe (SWD) water deficit, and their interaction with air [CO2], on the photosynthetic apparatus of Coffea canephora Pierre ex A. Froehner cv. Conilon Clone 153 (CL153) and Coffea arabica L. cv. Icatu. Seven year-old potted plants grown under 380 (aCO2) or 700 μl l −1 (eCO2) [CO2] gradually reached predawn water potentials between −1.6 and −2.1 MPa (MWD), and below −3.5 MPa (SWD). Under drought, stomata closure was chiefly related to abscisic acid (ABA) rise. Increasing drought severity progressively affected gas exchange and fluorescence parameters in both genotypes, with non-stomatal limitations becoming gradually dominating, especially regarding the photochemical and biochemical components of CL153 SWD plants. In contrast, Icatu plants were highly tolerant to SWD, with minor, if any, negative impacts on the potential photosynthetic functioning and components (e.g., Amax, Fv/Fm, electron carriers, photosystems (PSs) and ribulose-1,5-bisphosphate carboxylase oxygenase (RuBisCO) activities). Besides, drought-stressed Icatu plants displayed increased abundance of a large set of proteins associated with the photosynthetic apparatus (PSs, light-harvesting complexes, cyclic electron flow, RuBisCO activase) regardless of [CO2]. Single eCO2 did not promote stomatal and photosynthetic down-regulation in both genotypes. Instead, eCO2 increased photosynthetic performance, moderately reinforced photochemical (PSs activity, electron carriers) and biochemical (RuBisCO, ribulose-5-phosphate kinase) components, whereas photoprotective mechanisms and protein abundance remained mostly unaffected. In both genotypes, under MWD, eCO2 superimposition delayed stress severity and promoted photosynthetic functioning with lower energy dissipation and PSII impacts, whereas stomatal closure was decoupled from increases in ABA. In SWD plants, most impacts on the photosynthetic performance were reduced by eCO2, especially in the moderately drought affected CL153 genotype, although maintaining RuBisCO as the most sensitive component, deserving special breeder’s attention to improve coffee sustainability under future climate scenarios.
Amniotic Fluid Embolism: Principles of Early Clinical Management
Authors: Pacheco L.D. , Clark S.L. , Klassen M. , Hankins G.D.V. 
Published: November 2020

(Am J Obstet Gynecol. 2020;222:48–52)
Amniotic fluid embolism (AFE) affects up to 6.1 per 100,000 births and has a mortality rate of up to 60%. Developing interventions and protocols for this rare condition is difficult because of its unpredictable nature. In this Clinical Opinion, the authors provide recommendations for the management of AFE in pregnant women.
Obstetric Anesthesia During the Coronavirus Disease 2019 Pandemic
Authors: Bauer M.E. , Bernstein K. , Dinges E. , Delgado C. , El-Sharawi N. , Sultan P. , Mhyre J.M. , Landau R. 
Published: November 2020

(Anesth Analg. 2020;131:7–15)
When caring for obstetric patients infected with coronavirus disease 2019 (COVID-19), there are a number of factors to consider to safeguard the pregnant or postpartum woman and health care workers. The goal of this review was to provide recommendations based on evidence or expert opinion for anesthesiologists caring for pregnant women in the age of COVID-19.
Carbetocin Reduces the Need for Additional Uterotonics in Elective Cesarean Delivery: A Systematic Review, Meta-analysis, and Trial Sequential Analysis of Randomized Controlled Trials
Authors: Onwochei D.N. , Van Ross J. , Singh P.M. , Salter A. , Monks D.T. 
Published: November 2020

(Int J Obstet Anesth. 2019;40:4–23)
Uterine atony is the most common (70%) cause of postpartum hemorrhage (PPH). While oxytocin has been shown to effectively treat PPH, rescue uterotonics are needed in as many as 13% of women undergoing elective cesarean delivery (CD) to achieve adequate uterine tone. Some studies have suggested carbetocin is superior to oxytocin in minimizing blood loss and the need for additional uterotonics, although systematic reviews examining its ability to reduce the incidence of PPH have yielded varied results. These reviews have included both emergency and elective CDs, however, and have been limited by their traditional meta-analysis structure. This review used trial sequential analysis (TSA), which has been shown to prevent false-positive results, to compare carbetocin with oxytocin for its effectiveness in the prevention of uterine and PPH during elective CD.
Prevalence and Outcomes of Prenatal Recreational Cannabis Use in High-income Countries: A Scoping Review
Authors: Singh S. , Filion K.B. , Abenhaim H.A. , Eisenberg M.J. 
Published: November 2020

(BJOG. 2020;127:8–16)
With the potency of recreational cannabis on the rise, there is a need for an updated review of recent studies on pregnancy outcomes. Thus far, only 2 review studies have assessed the use of cannabis on maternal and neonatal outcomes. However, these reviews provided conflicting results and included studies only from before 2000. This study aimed to assess the prevalence of recreational cannabis use in pregnant women, its association with maternal and neonatal outcomes, and the potential impact of its legalization.
Trials and Tribulations of Viscoelastic-based Determination of Fibrinogen Concentration
Authors: Ranucci M. , Di Dedda U. , Baryshnikova E. 
Published: November 2020

(Anesth Analg. 2020;130:644–653)
One cause for severe bleeding in various clinical situations (such as cardiac surgery or trauma) is acquired fibrinogen deficiency. Current guidelines suggest both fibrinogen supplementation in patients who are bleeding with fibrinogen levels <1.5 g/L, as well as the application of viscoelastic tests (VETs) for a rapid determination of functional levels of fibrinogen. This procedure then entails translating values obtained with a VET into fibrinogen concentration correspondent values, a process that is far from perfect and includes many possible biases. The purpose of this review was to address issues with VET-based fibrinogen concentration measurement via different devices, along with their correlating Clauss-based measurement and the correlating values obtained via different devices.
Grandmultiparity, Maternal Age, and the Risk for Uterine Rupture—A Multicenter Cohort Study
Authors: Hochler H. , Wainstock T. , Lipschuetz M. , Sheiner E. , Ezra Y. , Yagel S. , Walfisch A. 
Published: November 2020

(Acta Obstet Gynecol Scand. 2020;99:267–273)
The rare complication of uterine rupture can potentially result in catastrophic consequences for both mother and fetus. The most common risk factor for uterine rupture is previous cesarean delivery (CD), but few published studies exist addressing uterine rupture in women without a history of previous CD. Conflicting conclusions have been reported regarding any association between grandmultiparity and uterine rupture. In this population, obstetricians have been cautious due to a fear of increased risk for uterine rupture. This approach might trigger the performance of unnecessary CDs. Therefore, this study was undertaken to determine if grandmultiparity is an independent risk factor for intrapartum uterine rupture in women without a history of previous uterine surgery.
Patient-centred Perioperative Mobile Application in Cesarean Delivery: Needs Assessment and Development
Authors: Ke J.X.C. , George R.B. , Wozney L. , Chorney J.L. 
Published: November 2020

(Can J Anesth/J Can Anesth. 2019;66:1194–1201)
There are multiple obstetric and anesthetic complications related to cesarean delivery (CD), including infection, postoperative pain, postdural puncture headache, and nerve injury. Because of the high prevalence of CDs in Canada, it is critical to ensure optimal preoperative preparation, provide relevant patient education, and monitor postoperative complications. The goal of this study was to design a mobile application to enhance the perioperative care of elective CD patients using input from both patients and anesthesiologists.
Maternal and Neonatal Characteristics in Obstetric Intensive Care Unit Admissions
Authors: Seppa¨nen P. , Sund R. , Uotila J. , Helminen M. , Suominen T. 
Published: November 2020

(Int J Obstet Anesth. 2020;41:65–70)
The World Health Organization defines severe acute maternal morbidity as “a woman who nearly died, but survived a complication that occurred during pregnancy, childbirth or within 42 days of termination of pregnancy.” Intensive care unit (ICU) admission resulting from maternal morbidity is most commonly associated with hemorrhage-related cardiovascular instability and severe preeclampsia. This retrospective register-based study from January 2007 to December 2011 held 3 objectives: (1) to evaluate the course of pregnancy and delivery for obstetric patients admitted to ICU, (2) discern the health status of infants born to those women, and (3) comparison of the results with reference data on Finnish parturients and infants.
Planned Vaginal Delivery and Cardiovascular Morbidity in Pregnant Women With Heart Disease
Authors: Easter S.R. , Rouse C.E. , Duarte V. , Hynes J.S. , Singh M.N. , Landzberg M.J. , Valente A.M. , Economy K.E. 
Published: November 2020

(Am J Obstet Gynecol. 2020;222:77.e1–77.e11)
Pregnant women with cardiovascular disease (CVD) are at increased risk for adverse obstetric and cardiac events. The few prior studies that have examined this issue have focused on these risks for pregnant women with CVD compared with those without CVD. While this type of analysis helps to assess the overall risk, it does not provide guidance on the clinical management of this patient population. The aim of this study was to assess whether there is an association between CVD in pregnancy and the planned mode of delivery.
Comparison of Spontaneous Versus Operative Vaginal Delivery Using Obstetric Quality of Recovery-10 (ObsQoR-10): An Observational Cohort Study
Authors: Sultan P. , Kormendy F. , Nishimura S. , Carvalho B. , Guo N. , Papageorgiou C. 
Published: November 2020

(J Clin Anesth. 2020;63:109781)
Within the UK, operative vaginal delivery rates are estimated at between 10% and 13% of deliveries, which accounts for an ∼85,000 births in 2018 within England and Wales. The US, by contrast, estimates a 3% rate, which is ∼115,000 births in 2018. The primary goal of this study was to investigate the patient recovery for both types of vaginal deliveries, to determine whether postpartum treatment of these patients ought to be individualized due to labor type or remain more universal for all deliveries as it currently exists. Authors hypothesized that a spontaneous vaginal delivery would yield a better recovery when compared with an operative vaginal delivery.
Outcomes Following a Clinical Algorithm Allowing for Delayed Hysterectomy in the Management of Severe Placenta Accreta Spectrum
Authors: Zuckerwise L.C. , Craig A.M. , Newton J.M. , Zhao S. , Bennett K.A. , Crispens M.A. 
Published: November 2020

(Am J Obstet Gynecol. 2020;222:179.e1–179.e9)
Placenta accreta spectrum (PAS) is a major risk factor for maternal injury and death, with an estimated morbidity rate of 24% to 67% and an estimated mortality rate of up to 7%. The current recommendations for treatment of PAS focus on immediate cesarean hysterectomy, but given the significant morbidity of PAS, new treatment strategies are needed. This study assessed the outcomes of patients with an antenatal diagnosis of placenta percreta that was managed with delayed hysterectomy versus patients who had an immediate cesarean hysterectomy.
Impact of Intraoperative Dexamethasone After Scheduled Cesarean Delivery: A Retrospective Study
Authors: Nanji J. , Guo N. , Riley E. , Carvalho B. 
Published: November 2020

(Int J Obstet Anesth. 2020;41:39–46)
In current anesthesia practice, a common preventative medication for postoperative nausea and/or vomiting (PONV) is dexamethasone. However, its efficacy when administered as a single intraoperative dose for procedures performed under spinal anesthesia is unclear. Analgesic effects of dexamethasone administered in the perioperative period have also been described in the literature. The investigators of this impact study aimed to determine the postoperative benefits from the administration of a single dose of intravenous (IV) dexamethasone during cesarean delivery (CD) performed under spinal or combined spinal epidural (CSE) anesthesia.
Intimate Partner Violence During Pregnancy and Risk of Fetal and Neonatal Death: A Meta-analysis With Socioeconomic Context Indicators
Authors: Pastor-Moreno G. , Ruiz-Pérez I. , Henares-Montiel J. , Petrova D. 
Published: November 2020

(Am J Obstet Gynecol. 2020;222:123.e5–133.e5)
It is estimated that 30% of women have experienced intimate partner violence (IPV) during their lifetime. IPV in pregnancy can cause both immediate (uterine rupture, fetal and maternal death) and long-term sequelae (low birthweight and prematurity) that are associated with increased risk of fetal and neonatal death. While maternal conditions, such as psychosocial stressors, infectious diseases, and environmental exposures, have been shown to impact fetal and neonatal health, the association between IPV and fetal and neonatal mortality has not been studied comprehensively. This study aimed to summarize the results of observational studies investigating the risk of perinatal death as a direct function of IPV as well as examine how socioeconomic factors may influence this association.
Placental Growth Factor Predicts Time to Delivery in Women With Signs or Symptoms of Early Preterm Preeclampsia: A Prospective Multicenter Study
Authors: Barton J.R. , Woelkers D.A. , Newman R.B. , Combs C.A. , How H.Y. , Boggess K.A. , Martin J.N. , Kupfer K. , Sibai B.M. 
Published: November 2020

(Am J Obstet Gynecol. 2020;222:259.e1–259.e11)
There is a clear need for quantitative testing methods to determine which patients with signs of preeclampsia may be at heightened risk for adverse pregnancy outcomes. The altered angiogenic factor concentrations including placental growth factor (PlGF) have been found to be associated with preeclampsia and precede the onset of preeclampsia by several weeks. While previous studies have found encouraging evidence that PlGF concentrations may predict adverse pregnancy outcomes, the association between angiogenic factors and time to delivery (TTD) is still unclear. This study aimed to examine the relationship between TTD and PlGF in pregnant women with gestational age <35 weeks with signs of preeclampsia and to evaluate the performance of PlGF as a predictor for TTD.