bluuebunny/crossref_metadata_2025_split huggingface dataset:
Education Competencies for Integrative Oncology—Results of a Systematic Review and an International and Interprofessional Consensus Procedure
Authors: Witt Claudia M. , Balneaves Lynda G. , Carlson Linda E. , Cohen Misha , Deng Gary , Fouladbakhsh Judith M. , Kinney Anita Y. , Mehta Ashwin , Mailman Josh , Pole Laura , Rogge Alizé A. , O’Toole Carole , Zick Suzanna M. , Helmer Stefanie M. 
Published: August 2020

AbstractIntegrative oncology is a burgeoning field and typically provided by a multiprofessional team. To ensure cancer patients receive effective, appropriate, and safe care, health professionals providing integrative cancer care should have a certain set of competencies. The aim of this project was to define core competencies for different health professions involved in integrative oncology. The project consisted of two phases. A systematic literature review on published competencies was performed, and the results informed an international and interprofessional consensus procedure. The second phase consisted of three rounds of consensus procedure and included 28 experts representing 7 different professions (medical doctors, psychologists, nurses, naturopathic doctors, traditional Chinese medicine practitioners, yoga practitioners, patient navigators) as well as patient advocates, public health experts, and members of the Society for Integrative Oncology. A total of 40 integrative medicine competencies were identified in the literature review. These were further complemented by 18 core oncology competencies. The final round of the consensus procedure yielded 37 core competencies in the following categories: knowledge (n = 11), skills (n = 17), and abilities (n = 9). There was an agreement that these competencies are relevant for all participating professions. The integrative oncology core competencies combine both fundamental oncology knowledge and integrative medicine competencies that are necessary to provide effective and safe integrative oncology care for cancer patients. They can be used as a starting point for developing profession-specific learning objectives and to establish integrative oncology education and training programs to meet the needs of cancer patients and health professionals.
Guidance and Standards for Breast Cancer Care in Europe
Authors: De Wilde Rudy Leon , Devassy Rajesh , Torres-de la Roche Luz Angela , Krentel Harald , Tica Vlad , Cezar Cristina 
Published: August 2020

AbstractThe increasing incidence and mortality rates of breast cancer have led to the necessity of initiating and developing clinical practice guidelines in order to optimize cancer control and provide patients with the best care. These guidelines are either national or issued by reputed relevant European societies—like European Society for Medical Oncology. Many of the recommendations are concordant in-between the guidelines. However, there are still considerable discrepancies to be noted between guidelines from different European countries, which could hinder physicians from implementing their recommendations. The present paper summarizes and compares the recommendations included in the various European guidelines.
A human circulating immune cell landscape in aging and COVID-19
Authors: Zheng Yingfeng , Liu Xiuxing , Le Wenqing , Xie Lihui , Li He , Wen Wen , Wang Si , Ma Shuai , Huang Zhaohao , Ye Jinguo , Shi Wen , Ye Yanxia , Liu Zunpeng , Song Moshi , Zhang Weiqi , Han Jing-Dong J. , Belmonte Juan Carlos Izpisua , Xiao Chuanle , Qu Jing , Wang Hongyang , Liu Guang-Hui , Su Wenru 
Published: August 2020

AbstractAge-associated changes in immune cells have been linked to an increased risk for infection. However, a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking. Here, we combined scRNA-seq, mass cytometry and scATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19. We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector, cytotoxic, exhausted and regulatory cells, along with increased late natural killer cells, age-associated B cells, inflammatory monocytes and age-associated dendritic cells. In addition, the expression of genes, which were implicated in coronavirus susceptibility, was upregulated in a cell subtype-specific manner with age. Notably, COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senescence. Therefore, these findings suggest that a dysregulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly.
Plasmonic Refractive Index Sensors Based on One- and Two-Dimensional Gold Grating on a Gold Film
Authors: Zhu Jiankai , Wang Xiangxian , Wu Yuan , Su Yingwen , Jia Tianxu , Yang Hua , Zhang Liping , Qi Yunping , Wen Xiaolei 
Published: August 2020

AbstractIn this paper, we propose two kinds of composite structures based on the one- and two-dimensional (1D&2D) gold grating on a gold film for plasmonic refractive index sensing. The resonance modes and sensing characteristics of the composite structures are numerically simulated by the finite-difference time-domain method. The composite structure of the 1D gold semi-cylinder grating and gold film is analyzed first, and the optimized parameters of the grating period are obtained. The sensitivity and figure of merit (FOM) can reach 660RIU/nm and 169RIU−1, respectively. Then, we replace the 1D grating with the 2D gold semi-sphere particles array and find that the 2D grating composite structure can excite strong surface plasmon resonance intensity in a wider period range. The sensitivity and FOM of the improved composite structure can reach 985RIU/nm and 298 RIU−1, respectively. At last, the comparison results of the sensing performance of the two structures are discussed. The proposed structures can be used for bio-chemical refractive index sensing.
The Funk–Radon transform for hyperplane sections through a common point
Authors: Quellmalz Michael 
Published: August 2020

AbstractThe Funk–Radon transform, also known as the spherical Radon transform, assigns to a function on the sphere its mean values along all great circles. Since its invention by Paul Funk in 1911, the Funk–Radon transform has been generalized to other families of circles as well as to higher dimensions. We are particularly interested in the following generalization: we consider the intersections of the sphere with hyperplanes containing a common point inside the sphere. If this point is the origin, this is the same as the aforementioned Funk–Radon transform. We give an injectivity result and a range characterization of this generalized Radon transform by finding a relation with the classical Funk–Radon transform.
Foundation Giving and Economics Research Productivity at HBCUs: Empirical Evidence from the Koch Foundation
Authors: Deng Shuyi , Lai Yufeng , Myers Samuel L. , Xu Man 
Published: August 2020

AbstractExisting research on funding disparities between historically black colleges and universities (HBCUs) and non-HBCUs primarily focuses on government funding and pays little attention to foundation giving. This paper helps to fill this gap by examining the effects of funding by the Charles Koch Foundation—a major funder of economics research in the USA—on the economics research productivity at HBCUs. Using data from the foundation’s tax forms, the Integrated Postsecondary Education Data System (IPEDS), and Scopus, this paper examines factors that explain the foundation’s grant results and how the foundation’s money affects economics research productivity at HBCUs. The paper estimates the effects of Koch funding on three different measures of HBCU productivity: number of publications, citations, and publications in top economics journals. We report ordinary least squares, two-step generalized linear model, and Poisson results that show little or no impact from (a) recipiency of a Koch grant, (b) the total amount of grant dollars, or (c) the average amount of grant dollars on research productivity. We also obtain event study and difference-in-differences estimates of the effects of Koch grants to HBCUs on publications and publications per faculty member and again find no statistically significant impacts. The evidence obtained—consistent across different model specifications and estimation techniques—does not support the hypothesis that Koch’s funding to HBCUs is primarily geared towards enhancing the research productivity of these colleges and universities. The paper discusses alternative explanations for the Charles Koch Foundation’s targeting strategy and its involvement with particular HBCUs.
Impact on clinical practice of the preoperative screening of Covid-19 infection in surgical oncological patients. Prospective cohort study
Authors: Castellvi J. , Jerico C. , DeMiguel A. , Camacho D. , Mullerat J.M. , Catala J. , Cliville R. , Videla S. 
Published: August 2020

ABSTRACT

Background:
In the oncological patient, an COVID-19-Infection, whether symptomatic or asymptomatic, a surgical procedure may carry a higher postoperative morbidity and mortality. The aim of this study was to describe the impact on clinical practice of sequential preoperative screening for COVID-19-infection in deciding whether to proceed or postpone surgery.

Methods:
Prospective, cohort study, based on consecutive patients’ candidates for an oncological surgical intervention. Sequential preoperative screening for COVID-19-infection: two-time medical history (telematic and face-to-face), PCR and chest CT, 48 h before of surgical intervention. COVID-19-infection was considered positive if the patient had a suggestive medical history and/or PCR-positive and/or CT of pneumonia.

Results:
Between April 15th and May 4th, 2020, 179 patients were studied, 97 were male (54%), mean (sd) age 66.7 (13,6). Sequential preoperative screening was performed within 48 h before to surgical intervention. The prevalence of preoperative COVID-19-infection was 4.5%, 95%CI:2.3–8.6% (8 patients). Of the operated patients (171), all had a negative medical history, PCR and chest CT. The complications was 14.8% (I-II) and 2.5% (III-IV). There was no mortality. The hospital stay was 3.1 (sd 2.7) days.
In the 8 patients with COVID-19-infection, the medical history was suggestive in all of them, 7 presented PCR-positive and 5 had a chest CT suggestive of pneumonia. The surgical intervention was postponed between 15 and 21 days.

Conclusion:
Preoperative screening for COVID-19-infection using medical history and PCR helped the surgeon to decide whether to go ahead or postpone surgery in oncological patients. The chest CT may be useful in unclear cases.

Highlights:
Beyond choice architecture: a building code for structuring climate risk management decisions
Authors: ÁRVAI JOSEPH , GREGORY ROBIN 
Published: August 2020

AbstractAlthough the need for urgent climate change action is clear, insights about how to make better climate risk management decisions are limited. While significant attention from behavioral researchers has focused on choice architecture, we argue that many of the contexts for addressing climate risks require increased attention to the needs of a deliberative and dynamic choice environment. A key facet of this kind of decision is the need for decision-makers and stakeholders to identify and balance conflicting economic, social and environmental objectives. This recognition of difficult, context-specific trade-offs highlights the need for structuring the decision-making process so that objectives are clearly articulated and prioritized. Equally, policy analyses and deliberations must effectively link priorities with climate risk management options. This restructuring of decision-making about climate change calls for more than a nudge. Scientific and technical efforts must be redirected to help stakeholders and decision-makers better understand the diverse implications of climate change management alternatives and to become better equipped to take actions commensurate with the urgency of the problem.
‘An Irish Louvain’: memories of 1914 and the moral climate in Britain during the Irish War of Independence
Authors: Madigan Edward 
Published: August 2020

AbstractWhen the British government declared war against Germany in August 1914, a great drive to gain popular support by presenting the conflict to the public as a morally righteous endeavour began in earnest. Stories of German violence against French and Belgian civilians, largely based in fact, were central to this process of ‘cultural mobilisation’. The German serviceman thus came to be widely regarded in Britain as inherently cruel and malevolent while his British counterpart was revered as the embodiment of honour, chivalry and courage. Yet by the autumn of 1920, less than two years after the Armistice, the conduct of members of the crown forces in Ireland was being publicly drawn into question by British commentators in a manner that would have been unthinkable during the war against Germany. Drawing on contemporary press reports, parliamentary debates and personal narrative sources, this article explores and analyses the moral climate in Britain in 1920 and 1921 and comments on the degree to which memories of atrocities committed by German servicemen during the Great War informed popular and official responses to events in Ireland.
Sacco and Vanzetti, Mary Donovan and transatlantic radicalism in the 1920s
Authors: Whelehan Niall 
Published: August 2020

AbstractIn 1927 the Italian anarchists Nicola Sacco and Bartolomeo Vanzetti were executed in Boston following a murder trial that was widely denounced for its anti-labour and anti-immigrant bias. From 1921 the campaign to save the two men powerfully mobilised labour internationalism and triggered waves of protests across the world. This article examines the important contributions made by Irish and Irish-American radicals to the Sacco-Vanzetti campaign. Mary Donovan was a leading member of the Sacco-Vanzetti Defense Committee, and a second-generation Irish union organiser and member of Boston's James Connolly Club. In the 1920s she travelled to Ireland twice and appealed to Irish and Irish American labour to support the campaign. At the same time, Donovan and many of the activists considered here held ambiguous personal and political relationships with Ireland. Transnational Irish radicalism in the early-twentieth century is most commonly considered in nationalist terms. Taking a distinctly non-Irish cause – the Sacco-Vanzetti case of 1920–7 – allows us to look from a different perspective at the global Irish Revolution and reveals how radical labour currents reached into Irish and Irish-American circles during the revolutionary era, though the response to the campaign also indicates a receding internationalism in the immediate aftermath of Irish independence.
Ensemble matching of repeat satellite images applied to measure fast-changing ice flow, verified with mountain climber trajectories on Khumbu icefall, Mount Everest
Authors: Altena Bas , Kääb Andreas 
Published: August 2020

AbstractVelocities within an icefall are typically the fastest within a glacier system and experience complex flow. The combination of convergent and fast flow, and steep slope generate a quickly changing and intensely fractured surface. This complicates velocity extraction from repeat satellite images, especially when common pattern matching procedures are used. In this study, we exploit the high temporal revisit of medium-resolution satellite images using a novel image matching technique, ensemble matching, making it possible to generate a high-resolution (30 m) velocity field from high-repeat image sequences despite challenging image conditions. We demonstrate this technique for the first time in the glaciology domain using repeat Sentinel-2 optical data over the famous Khumbu icefall, situated on the southern slopes of Mount Everest. Estimates of velocity go just over 1 m d−1, which is slower than summer velocities from noisy single pair image matching. This icefall is frequently crossed by high-altitude mountaineers who use a route confined by fixed ropes and ladders set out every season. The mountain climbers typically record their trajectory on their personal satellite navigation device. We use such volunteered geographic information to verify our velocity estimates, confirming our underestimation with ensemble matching. Besides unprecedented remotely sensed surface velocities over the icefall, we also note that the generated velocity field can aid with the planning of a safe passage through this icefall.
Varying ensiling conditions affect the fermentation quality and abundance of bacterial key players in lucerne silages
Authors: Hartinger T. , Kube K. , Gresner N. , Südekum K.-H. 
Published: August 2020

AbstractThe successful ensiling of lucerne (Medicago sativa L.) depends on a rapid acidification in the silo and consequently relies on a sufficient proliferation of, particularly homofermentative, lactic acid bacteria. Similarly, growth of spoilage bacteria, such as enterobacteria and clostridia, must be suppressed and silage additives are therefore frequently applied to promote favourable conditions during ensiling. Three silage additives or soil were applied during lucerne ensiling and investigated for their effects on silage quality characteristics and abundances of total bacteria as well as the bacterial key players Lactobacillus spp., homofermentative Lact. plantarum, heterofermentative Lact. buchneri, Clostridium spp. and Enterobacteriaceae after 30 days of storage. Inoculation with viable Lact. plantarum resulted in highest concentration of this species and excellent silage quality, i.e. high lactic acid concentration coupled with low acetic acid and ammonia-nitrogen concentrations. A sodium nitrite and hexamine-based additive did not support growth of lactic acid bacteria, which was also apparent by higher pH and low lactic acid concentration. No effect of treatments was found on spoilage-related enterobacteria and clostridia, even not when adding soil to lucerne to increase initial clostridial contamination. However, soil treatment resulted in increased ammonia-nitrogen and acetic acid concentrations. Consequently, among the bacterial key players, lactic acid bacteria concentrations were related to silage quality. Regarding spoilage bacteria, however, alterations in silage quality characteristics were not reflected in the abundances of enterobacteria and clostridia. Future investigations should underpin the present findings and help to understand how silage additives affect microbial key players and silage fermentation.
Evaluation of cellulolytic exogenous enzyme-containing microbial inoculants as feed additives for ruminant rations composed of low-quality roughage
Authors: Zayed M. S. , Szumacher-Strabel M. , El-Fattah D. A. A. , Madkour M. A. , Gogulski M. , Strompfová V. , Cieślak A. , El-Bordeny N. E. 
Published: August 2020

AbstractThe supplementation of ruminant diets with exogenous cellulolytic enzymes can improve their digestibility and feeding value. The objective of this study was to determine the effect of supplementing roughage (rice straw) and concentrate with inoculants containing four fungal strains (Pleurotus ostreatus, Phanerochaete chrysosporium, Trichoderma reesei and Trichoderma viride) and four bacterial strains (Paenibacillus polymyxa, Bacillus megaterium, Bacillus circulans and Bacillus subtilis), given separately or as a mixture, as a source of exogenous cellulolytic enzymes, on basic rumen parameters in vitro, including digestibility and methane production. A batch culture trial was used to select the best supplements, and a long-term rumen simulation technique (RUSITEC) was used to evaluate the effects of P. chrysosporium, B. subtilis, and a 1 : 1 mixture of these two on dietary component digestibility and fermentation parameters. In the batch culture evaluation, there were significant increases in the organic matter (OM) digestibility, the total gas production expressed as ml/g of dry matter, the OM, the neutral detergent fibre (NDF) and the acid detergent fibre (ADF) of the supplemented rations, as compared to the control, excluding the rations supplemented with T. viride and B. circulans. In the RUSITEC, the ration supplemented with mixed inoculants showed significantly higher digestibility of crude protein, ether extract, NDF and ADF than did the ration supplemented with the P. chrysosporium and B. subtilis inoculants. It can be concluded that the simultaneous use of fungal and bacterial exogenous cellulases on rice straw roughage improves its digestibility, without negative effects on other rumen parameters.
Genetic load and biological changes to extant humans
Authors: Saniotis Arthur , Henneberg Maciej , Mohammadi Kazhaleh 
Published: August 2020

AbstractExtant humans are currently increasing their genetic load, which is informing present and future human microevolution. This has been a gradual process that has been rising over the last centuries as a consequence of improved sanitation, nutritional improvements, advancements in microbiology and medical interventions, which have relaxed natural selection. Moreover, a reduction in infant and child mortality and changing societal attitudes towards fertility have led to a decrease in total fertility rates (TFRs) since the 19th century. Generally speaking, decreases in differential fertility and mortality have meant that there is less opportunity for natural selection to eliminate deleterious mutations from the human gene pool. It has been argued that the average human may carry ~250–300 mutations that are mostly deleterious, as well as several hundred less-deleterious variants. These deleterious alleles in extant humans mean that our fitness is being constrained. While such alleles are viewed as reducing human fitness, they may also have had an adaptive function in the past, such as assisting in genetic complexity, sexual recombination and diploidy. Saying this, our current knowledge on these fitness compromising alleles is still lacking.
Diet composition and some observations on the feeding ecology of the rhizostome Rhopilema nomadica in Israeli coastal waters
Authors: Kuplik Z. , Angel D. L. 
Published: August 2020

AbstractSince the mid-1980s, swarms of the rhizostome Rhopilema nomadica have been an annual phenomenon in Israeli Mediterranean coastal waters during the summer months. Despite its annual prominence and the potential impact on food webs and ecosystem services, studies concerning its feeding ecology and its interactions with other biota in the marine food web have not been conducted. During summer 2015 gut contents of 41 R. nomadica were analysed as well as ambient plankton assemblages. More than 60% of the medusae diet was found to consist of microzooplankton <150 μm. Size correlations revealed that larger R. nomadica consumed faster swimming prey while smaller medusae relied more on the slower swimming taxa. The medusan diet reflected most of the ambient plankton taxa, but no statistically significant correlations between the relative abundance in diet and ambient plankton were found. As summer progressed, there was a gradual decrease in both mean medusa bell diameter (from 42.2–16 cm) and integrity of feeding structures. These findings suggest that R. nomadica, at least at the time of its appearance in Israeli coastal waters, may exert less predatory pressure on the plankton than we might otherwise expect.