bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic and clinicopathological significance of long non-coding RNA UCA1 in colorectal cancer
Authors: Liu Xiaoqun , Liu Xiangdong , Qiao Tiankui , Chen Wei 
Published: November 2019

Abstract

Objective:
Urothelial cancer-associated 1 (UCA1), an oncogenic long non-coding RNA, was aberrantly upregulated in colorectal cancer (CRC). This study aimed to further explore the clinical value of UCA1 in CRC.

Methods:
Eligible studies were retrieved by searching Pubmed, Embase, Cochrane Library, Web of Science, Chinese National Knowledge Infrastructure, and Wanfang databases. Pooled hazard ratio (HR) and odds ratio (OR) with 95% confidence interval (CI) were applied to assess the prognostic role and clinical significance of UCA1.

Results:
A total of 7 eligible studies with 775 cancer patients were recruited in the meta-analysis. The results showed that UCA1 overexpression was significantly correlated with poor overall survival in patients with CRC (HR = 2.25, 95% CI: 1.77–2.87, P < .001). There was also a significantly negative association between high UCA1 levels and tumor differentiation (OR = 2.84, 95% CI: 1.87–4.31, P < .001), lymph node metastasis (OR = 3.48, 95% CI: 2.24–5.41, P < .001), distant metastasis (OR = 2.67, 95% CI: 1.32–5.38, P = .006), tumor node metastasis stage (OR = 3.01, 95% CI: 2.16–4.18, P < .001), tumor invasion depth (OR = 2.18, 95% CI: 1.03–4.61, P = .04), and tumor size (OR = 2.27, 95% CI: 1.56–3.32, P < .001).

Conclusions:
Our study revealed that UCA1 overexpression was associated with poor prognosis and more advanced clinicopathological features, suggesting that UCA1 may serve as an indicator for unfavorable outcome of patients with CRC.
Scalp acupuncture for children with cerebral palsy
Authors: Lee Go-Eun , Lee Pei-Ting , Ran Ni , Zhou Jianwei 
Published: November 2019

Abstract

Background:
Cerebral palsy (CP) describes a group of permanent disorders of movement and posture causing activity limitations, leading the most common movement disorder to children. Scalp acupuncture (SA) is one of several specialized acupuncture techniques, and it has been used widely in China to alleviate several CP symptoms, despite the deficiency of high-quality evidence related to this practice. Therefore, we plan to conduct a protocol of systematic review aimed at systematically reviewing all the clinical evidence on the effectiveness of scalp acupuncture for treating CP in children.

Methods:
The following electronic databases will be searched from inception to May 1, 2019 MEDLINE, PubMed, Web of Science, EMBASE, the Cochrane Central Register of Controlled Trials (Cochrane Library), Chinese National Knowledge Infrastructure (CNKI), Chinese Scientific Journals Database (VIP), Wan-fang Database, and Chinese Biomedical Literature Database (CBM). All published English and Chinese articles randomized controlled trials (RTCs) will be included. All types of CP of children in the trials will be included in this study and these individuals will be involved as core searchers to evaluate the efficacy of scalp acupuncture. Rev Man V.5.3 software will be implemented for the assessment of bias risk, data synthesis, subgroup analysis, and meta-analyses if inclusion conditions are met. Continuous outcomes will be presented as mean difference (MD) or standard mean difference (SMD), while dichotomous data will be expressed as a relative risk.

Results:
The systematic review will synthesize the available knowledge surrounding scalp acupuncture for children with CP. The findings will be synthesized to determine the efficacy and safety of scalp acupuncture for children with CP.

Conclusion:
This protocol will present the evidence of whether scalp acupuncture is an effective intervention for children with CP.
Combining micro-plasma radio-frequency with hypofractionated electron-beam radiation as a novel treatment of keloids
Authors: Zhang Wenchao , Liu Zhifei , Zhu Lin , Zeng Ang , Ting Wenyun , Wang Xiaojun , Yu Nanze , Xia Guangpeng 
Published: November 2019

Abstract

Rationale:
Micro-plasma radio-frequency (MPR) technology has been demonstrated a safe and effective treatment for kinds of scars, but there is no report about the application of the MPR on keloids. In this investigation, we creatively use MPR technology combining with hypofractionated electron-beam radiation to cure keloids.

Patient concerns and Diagnoses:
From February 2013 to December 2016, 22 Asian patients (16 male, 6 female, age 19–46 years, mean age 28.14 ± 7.31 years) with keloids over half a year were enrolled in this study.

Interventions and Outcomes:
All patients received a single MPR technology treatment by roller tip at 80–100 watt, and then hypofractionated electron-beam radiation of 6 MeV were performed twice, within 24 hours and one week after the operation with 9 Gy per time. Improvement were determined by the Vancouver Scar Scales (VSS) according to digital photographs. The results show that the volume of keloids reduced significantly among most patients. Only 3 patients encountered with mild to moderate hyperpigmentation, and none of malignance and worsening or recurrence of scars was observed.

Lessons:
MPR technology combined with post-operative hypofractionated electron-beam radiation therapy is an effective method for patients with multiple keloids distributed widely on the body with minimal complications, especially for patients with widely distributed keloids.
Failure of standard methods for retrieving an unusual foreign body in esophagus
Authors: Li Dongjie , Nan Ling , Niu Kai , Yin Wanzhong , Zhu Wei , Wang Xin 
Published: November 2019

Abstract

Rationale:
The ingestion of a foreign body (FB) with complete impaction of the esophagus is not common. Here we report a rare case of successful retrieval of a spherical stone in the esophagus of a man with mental retardation, using gallbladder grasping forceps and rigid endoscope.

Patient concerns:
A mental retarded man came to the emergency department presenting with recurrent nausea, vomiting, and dysphagia after swallowing a spherical stone. He had previously undergone an FB extraction under general anesthesia by fiberoptic esophagoscopy, which failed.

Diagnosis:
The diagnosis of FB ingestion was confirmed by anteroposterior plain film x-ray of the chest and chest computed tomography (CT), which showed the ingested spherical FB in the upper esophagus.

Interventions:
After multiple failed attempts using other instruments, the FB was successfully removed with gallbladder grasping forceps through a rigid esophagoscope.

Outcomes:
The patient was discharged without any complications. The nasogastric tube was extubated at the 10-day follow-up.

Lessons subsections as per style:
For esophageal retrieval of uncommon FBs, the instrument used is crucial. We report our experience retrieving a large and spherical FB in the upper esophagus using gallbladder grasping forceps. This proved to be an effective strategy, eliminating the need for thoracotomy.
Epiphora after nasolacrimal duct fracture in patients with midfacial trauma
Authors: Shim Woo Sub , Cho Min Jai , Kim Jisung , Jung Hahn Jin 
Published: November 2019

Abstract
The aim of this study was to identify the factors related to occurrence of epiphora or requirement of dacryocystorhinostomy (DCR) in patients with midfacial trauma.
We performed a retrospective analysis of the medical records of 1038 patients with midfacial trauma from January 2005 to December 2015. Fifty-one patients (55 cases) diagnosed with nasolacrimal duct (NLD) fracture using facial bone computed tomography were enrolled. Correlation analysis was performed of patient- and injury-related factors, including age, sex, facial trauma etiology, accompanying injury, type and level of the NLD fracture, and time from injury to initial surgery, with the occurrence of epiphora and requirement for DCR.
Epiphora occurred in 14.5% and DCR was performed in 5.5% of the patients with NLD fracture. The correlation analysis revealed no significant relationship among the factors with the occurrence of epiphora and requirement for DCR.
In patients with midfacial trauma and NLD fracture, epiphora occurred in 14.5% and endoscopic DCR was performed due to persistent epiphora in 5.5% and its result was all successful.
Medical management of a child with congenital generalized lipodystrophy accompanied with progressive myoclonic epilepsy
Authors: Zhang Yi , Chen Xiaofei , Luo Feixiang , Jiang Lihua , Xu Jialu , Chen Shuohui 
Published: November 2019

Abstract

Rationale:
Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive hereditary disease. It is associated with metabolic complications and epilepsy is rare.

Patient Concerns and Diagnoses:
One child with BSCL2 mutation and CGL accompanied by progressive myoclonic epilepsy
Diagnosis: He was diagnosed with epilepsy, CGL, and severe malnutrition.

Interventions:
He was treated with sodium valproate, baclofen, aripiprazole, benzhexol, and lamotrigine for epilepsy.

Outcomes:
After 16 days of medical treatment for epilepsy, the disease was improved and the child was discharged with gastric tube inserted for the management of malnutrition.

Lessons:
CGL and progressive myoclonic epilepsy is rare, and the epilepsy is partially refractory to treatments. In this particular case, the nutritional status was compromised as a complication of progressive myoclonic epilepsy and had to be managed.
Association between colorectal cancer and zolpidem use in a case-control study
Authors: Lai Shih-Wei , Lin Cheng-Li , Liao Kuan-Fu 
Published: November 2019

Abstract
This study aimed to examine the association between colorectal cancer and zolpidem use in Taiwan.
A case-control study was conducted using the database of Taiwan National Health Insurance Program from 2000 to 2013. Participants aged 20 to 84 years with newly diagnosed colorectal cancer were selected as the cases. Sex-matched and age-matched participants without colorectal cancer were randomly selected as the matched controls. The odds ratio and 95% confidence interval for colorectal cancer associated with zolpidem use were calculated by the multivariable logistic regression model.
There were 4912 cases with colorectal cancer and 4912 matched controls without colorectal cancer. The mean age was 63 years and 58% were male participants. After adjustment for co-variables, the multivariable logistic regression model disclosed that there was no statistical association between colorectal cancer and zolpidem use (adjusted OR 1.05, 95% CI 0.95–1.15).
No statistical association can be detected between colorectal cancer and zolpidem use in Taiwan.
Effect of Balint training in gastroenterology intern nurse practitioners
Authors: Liu Wan-lu , Zhu Zheng-ri , Chen Chen , Li Jing , Moreno Olga 
Published: November 2019

Abstract

Background:
This study aims to assess the effect of Balint training (BT) in gastroenterology intern nurse practitioners (GINP) systematically.

Methods:
This study will search EMBASE, MEDLINE, PsycINFO, Web of Science, Cochrane Library, Cumulative Index to Nursing and Allied Health Literature, Allied and Complementary Medicine Database, and China National Knowledge Infrastructure from inception to the September 30, 2019 with no language limitation. In addition, we will also search grey records, such as conference abstracts and dissertations. Study quality will be checked using Cochran risk of bias tool. Statistical analysis will be performed using RevMan 5.3 software.

Results:
This study will systematically evaluate the effect of BT in GINP and will provide evidence to judge whether BT is effective for GINP clinically.

Conclusion:
The results of this study may provide helpful evidence of BT in GINP in the clinical training.
Exercise, headache, and factors associated with headache in chronic whiplash
Authors: Landén Ludvigsson Maria , Peterson Gunnel , Widh Simon , Peolsson Anneli 
Published: November 2019

Abstract

Background:
Almost 40% of individuals with chronic whiplash-associated disorders (WAD) report headache after 5 years, making it one of the most common persistent symptoms besides neck pain, but randomized treatment studies are lacking. This study aimed to evaluate the effect of 3 different exercise approaches on headache in chronic WAD grades 2 and 3, and to identify potential factors associated with such headache, and whether they differ depending on 3 different aspects of such headache (current headache, maximum headache, or headache bothersomeness).

Methods:
This was an analysis of a randomized clinical trial of people with chronic WAD and headache (n = 188), who were randomized to either 12 weeks of neck-specific exercise without (NSE) or with a behavioral approach (NSEB) or physical activity prescription (PPA). Data were collected at baseline and at 3, 6, and 12 months. Physical and psychosocial factors were tested for association with headache. Multivariate regression models and linear mixed models were used.

Results:
The NSE/NSEB groups reported reduced headache both over time and compared to PPA. Up to 51% (NSE) and 61% (NSEB) reported at least 50% reduction in their headache at 12 months. The PPA group was not improved over time. Neck pain and dizziness were associated with headache regardless of aspect of headache. The only associated psychosocial factor was anxiety, which was associated with headache bothersomeness. Other factors were mainly physical, and up to 51% of the variance was explained.

Conclusion:
Headache in chronic WAD, may be reduced with neck-specific exercise with or without a behavioral approach. Chronic headache was associated with neck pain and dizziness regardless of aspect tested. Other factors associated with headache in chronic WAD were mainly physical rather than psychosocial.

Trial registration number:
Clinical Trials.gov, no: NCT015285
Are safe guards at trampoline parks safe enough?
Authors: Lee Jae Eun , Kim Ju Hyun , Park Chan Hee , Gwak Dae Won , Kim Chul-Hyun , Park Donghwi , Hwang Jong-Moon 
Published: November 2019

Abstract

Rationale:
Recently, commercial indoor trampoline parks have been opened around the globe, and both the number of venues and the park users are increasing. Academic literatures have largely focused on home trampoline related injuries, and less is known about the injuries associated with trampoline parks due to the limited number of studies or cases reported. In this report, we present a complete spinal cord injury sustained at a commercial indoor trampoline park.

Patient Concerns:
A 26-year old male developed tetraplegia after plainly jumping on the trampolines and diving into one of the foam pits head first.

Diagnosis:
C-spine CT revealed bilateral interfacetal dislocation on C6-7, and his C-spine MRI showed anterior translational injury at C6-7 with severe cord encroachment and complete discoligamentous complex disruption. He was diagnosed with complete spinal cord injury.

Interventions:
The patient underwent 30 minutes each of physical therapy and occupational therapy twice a day for a total of 25 days of in-patient rehabilitation. Interventions included tilt table, passive range of motion exercises, functional electrical stimulation, sitting balance training, upper extremity strengthening exercise, and hand manipulation exercises.

Outcome:
Despite intensive rehabilitation and the patient's good spirit, there was no functional change in all physical examinations between evaluations at initial and at discharge.

Lessons:
In conclusion, we aim to alert the risks associated with improper use of trampolines, promote safer entertainment environment, and aid in developing mandatory safety measures. We hope to alert the risks associated with improper use of trampolines, promote safer entertainment environment, and aid in developing mandatory safety measures.
Contemporary full-mouth rehabilitation using a digital smile design in combination with conventional and computer-aided design/manufacturing restorative materials in a patient with bruxism
Authors: Lee Jae-Hyun , Kim Sung-Hun , Han Jung-Suk , Yeo In-Sung Luke , Yoon Hyung-In 
Published: November 2019

Abstract

Rationale:
Full-mouth rehabilitation of patients with bruxism and severely worn dentition poses a great challenge to clinicians. Several treatment planning methods and restorative materials are used to treat tooth wear in modern dentistry. Clinicians should be able to select the most suitable treatment planning methods and materials for individual patients depending on their specific situation.

Patient concerns:
A 47-year-old male was referred for evaluation of a severely worn dentition.

Diagnoses:
Clinical and radiographic evaluation revealed tooth wear in the entire dentition. The interocclusal distance at rest was 4 mm, and the patient had a parafunctional habit of bruxism.

Interventions:
A digital smile design was used to formulate a treatment plan. Full-mouth rehabilitation was performed using a combination of conventional and digital materials and methods.

Outcomes:
The full-mouth restoration showed satisfactory functions and esthetics. No complications were observed in the restorations, supporting tissues, and temporomandibular joints during 2-year follow-up.

Lessons:
In clinical practice, it is important to determine the optimal combination of the available methods for treatment planning. This case report details the formulation of a unique treatment plan for the dental rehabilitation of a severely worn out dentition, which is considered challenging due to the limitations imposed by biological tissues and restorative materials. The use of conventional and digital tools for treatment planning, patient education, and treatment execution was demonstrated.
Acute mental change as the presenting sign of posthepatectomy hepatic failure
Authors: Chon Jin Young , Moon Hye Young , Han Sangbin , Kwak Jueun , Lee Ji Young , Kim Eun Sung , Chung Hyun Sik 
Published: November 2019

Abstract

Rationale:
Hepatectomy is a treatment to increase survival and curability of patients with intrahepatic lesions or malignant tumors. However, posthepatectomy liver failure (PHLF) can occur. This case is a patient showing acute mental change in postanesthetic care unit (PACU) as an uncommon symptom of PHLF after extended right hepatectomy.

Patient concerns:
A 68-year-old male patient was admitted for surgery of Klatskin tumor. He had hypertension and atrial fibrillation. His model for end-stage liver disease score was 16 pts. His serum bilirubin and ammonia levels were 4.75 mg/dL and 132.8 mcg/dL, respectively. Other laboratory data were nonspecific. He underwent extended right hepatic lobectomy including segments IV-VIII for 9 hours. Weight of liver specimen was 1028 g which was about 58% of total liver volume based on computed tomographic volumetry. The patient was extubated and moved to the PACU with stable vital sign and regular self-breathing. He could obey verbal commands. Fifteen minutes after admission to the PACU, the patient showed abruptly decreasing mental status and self-breathing.

Diagnoses:
Brain computed tomography, blood culture, and sputum culture were performed to diagnose brain lesions and sepsis for evaluating the sudden onset comatous mental status. Results showed nonspecific finding.

Interventions:
He was intubated for securing airway and applying ventilatory care. The patient was moved to the intensive care unit. He received intensive conservative therapy including continuous renal replacement therapy and broad-spectrum antibiotics.

Outcomes:
The patient's condition was worsened. He expired on postoperative day 3.

Lessons:
Acute mental change is uncommon and rare as initial symptoms of PHLF. Therefore, clinician may overlook the diagnosis of PHLF in patients with acute mental change after hepatectomy. Thus, clinician should plan an aggressive treatment for PHLF including liver transplantation by recognizing any suspicious symptom, although such symptom is rare.
Tonic–clonic seizure during the ultrasound-guided stellate ganglion block because of an injection into an unrecognized variant vertebral artery
Authors: Lu Fan , Tian Jie , Dong Jifu , Zhang Kexian 
Published: November 2019

Abstract

Rationale:
Recent years have witnessed a marked improvement in the safety and accuracy of nerve blocks with the help of ultrasound and other visualization technologies. This study reports a challenging case of a severe complication during the ultrasound-guided stellate ganglion block.

Patient concerns:
A 28-year-old male patient with refractory migraine complained episodic pulsatile pain with photophobia, haphalgesia of the scalp for 3 years.

Interventions:
Ultrasound-guided stellate ganglion block with 4 ml of 1% lidocaine was administrated.

Outcomes:
A sudden loss of consciousness and tonic–clonic seizure was occurred after negative aspiration and test dose. Further sonographic examination revealed a variation in the left vertebral artery, which remained unrecognized during the needle insertion because of its sliding ability under the differential pressure applied by the probe.

Lessons:
Inadvertent intra-arterial injection of a local anesthetic agent could be minimized under the ultrasound guidance with various protective strategies, including the determination of any prior variation, optimizing the block route, maintaining a constant probe pressure, and using saline for the test dosage. This case resulted in the implementation of new protocols of the ultrasound-guided stellate ganglion block in our department.
Sinus of Valsalva aneurysm protruding into the mitral anterior leaflet causing dyspnea
Authors: Wang Baogang , Ma Dashi , Qu Limei , Cao Dianbo , Man Xiaxia 
Published: November 2019

Abstract

Introduction:
Sinus of Valsalva aneurysm (SVA) protruding into the mitral anterior leaflet is an extremely rare clinical condition; herein, we present a case of unruptured noncoronary SVA protruding into the mitral anterior leaflet.

Patient's concerns:
A 46-year-old male was referred to hospital for exertional dyspnea.

Diagnosis:
Transthoracic echocardiography (TTE) and coronary computed tomography angiography (CTA) suggested a noncoronary SVA protruding into the mitral anterior leaflet, causing mitral regurgitation and aortic insufficiency.

Interventions:
The aneurysm was resected and the aortic and mitral valves were replaced with mechanical valves via a transaortic approach.

Outcomes:
Postoperative recovery was uneventful.

Conclusions:
A rare noncoronary SVA protruding into the mitral anterior leaflet can be diagnosed via TTE and CTA. Transaortic mitral surgery is feasible in patients with a dilated aortic annulus ring and mitral valve diseases
Association between iron metabolism and cognitive impairment in older non-alcoholic fatty liver disease individuals
Authors: Xu Jing , Sun Weihao , Yang Li 
Published: November 2019

Abstract
Sparse is the research on the relationship between iron metabolism and mild cognitive impairment (MCI) in adults aged over 60 years with non-alcoholic fatty liver disease (NAFLD). The soluble transferrin receptor (sTfR), serum iron (SI), serum ferritin (SF), transferrin (TRF) and hemoglobin (HB) are indicators of iron metabolism.
This study examined whether iron metabolism is associated with cognitive impairment in older individuals.
A cross-sectional study was held in patients from a Chinese center. Individuals with NAFLD aged over 60 years were included if they did not have excessive alcohol intake and were free of stroke or dementia. Their cognitive function was assessed by the same neurologist. 3.0T H proton magnetic resonance spectroscopy (1H-MRS) was performed to evaluate the hippocampus of the participants without contraindication. t test and Chi-square test were used to analyze the data. Binary logistic regression was used for correlation analysis.
Fifty four (54%) of participants were diagnosed with MCI by the psychiatrist. MCI was significantly associated with higher sTfR after adjustment of all the covariates (OR = 2.565, 95%CI: 1.334∼4.934; P = .005). No statistically significant associations were observed between MCI and age or blood glucose or choline (Cho) /creatine (Cr) of theright hippocampus head.
Increased age and low levels of sTfR and HB were associated with MCI in NAFLD individuals aged over 60 years.