bluuebunny/crossref_metadata_2025_split huggingface dataset:
2′-5′-Oligoadenylate synthetase-like protein inhibits intracellular M. tuberculosis replication and promotes proinflammatory cytokine secretion
Authors: Leisching G. , Ali A. , Cole V. , Baker B. 
Published: October 2019

AbstractHost cytoplasmic surveillance pathways are known to elicit type I interferon (IFN) responses which are crucial to antimicrobial defense mechanisms. Oligoadenylate synthetase-like (OASL) protein has been extensively characterized as a part of the anti-viral mechanism, however a number of transcriptomic studies reveal its upregulation in response to infection with a wide variety of intracellular bacterial pathogens. To date, there is no evidence documenting the role (if any) of OASL during mycobacterium tuberculosis infection. Using two pathogenic strains differing in virulence only, as well as the non-pathogenic M. bovis BCG strain, we observed that pathogenicity and virulence strongly induced OASL expression after 24 h of infection. Further, we observed that OASL knock down led to a significant increase in M. tb CFU counts 96 h post-infection in comparison to the respective controls. Luminex revealed that OASL silencing significantly decreased IL-1β, TNF-α and MCP-1 secretion in THP-1 cells and had no effect on IL-10 secretion. We therefore postulate that OASL regulates pro-inflammatory mediators such as cytokines and chemokines which suppress intracellular mycobacterial growth and survival.
A structure equation model of indicators driving BIM adoption in the Bahraini construction industry
Authors: Ahmed Shurooq H.A. , Suliman Saad M.A. 
Published: October 2019

Purpose
This study aims to establish an adoption model using Structural Equation Modeling (SEM) that examines the relationship between several key indicators that drive building information modeling (BIM) adoption.

Design/methodology/approach
The study was carried out using quantitative approaches through the Delphi method and questionnaire survey. A total of 272 completed responses were collected and analyzed through the SEM technique using SPSS 25 and AMOS software.

Findings
The structural model shows that “environment” and partially “people” indicators are the leading indicators driving BIM adoption with path coefficient values of 0.280 and 0.332, respectively.

Originality/value
It is expected that these conclusions will lead the Bahraini construction industry stakeholders to raise the level of BIM adoption.
Aid and terrorism: a dynamic contracts approach with interlinked moral hazard
Authors: Roy Jaideep , Chowdhury Prabal Roy 
Published: October 2019

Purpose
In a global environment where terrorist organisations based in a poor country target a rich nation, this paper aims to study the properties of a dynamically incentive compatible contract designed by the target nation that involves joint counter-terror tasks with costly participation by each country. The counter-terror operations are however subject to ex post moral hazard, so that to incentivise counter-terror, the rich country supplies developmental aid. Development aid also helps avoid unrest arising from counter-terror activities in the target nation. However, aid itself can be diverted to non-developmental projects, generating a novel interlinked moral hazard problem spanning both tasks and rewards.

Design/methodology/approach
The authors use a dynamic model where the aid giving countries and aid receiving countries behave strategically. Then they solve for the sub game perfect Nash equilibrium of this game.

Findings
The authors characterise the optimal contract, showing that the dynamic structure of counter-terror resembles the shock-and-awe discussed by military strategists. The authors then prove that it is not necessarily the case that a more hawkish (resp. altruistic) donor is less pro-development (resp. softer on terror). In addition, the authors show that it may be easier to contract for higher counter-terror inputs when the recipient is more sympathetic to terrorists. The authors also discuss other problems faced by developing nations where this model can be readily adopted and the results can endorse appealing policy implications.

Originality/value
The authors characterise the optimal contract, showing that the dynamic structure of counter-terror resembles the shock-and-awe discussed by military strategists. It is proved that it is not necessarily the case that a more hawkish (resp. altruistic) donor is less pro-development (resp. softer on terror). In addition, the authors show that it may be easier to contract for higher counter-terror inputs when the recipient is more sympathetic to terrorists. Other problems faced by developing nations are also discussed where this model can be readily adopted, and the results can endorse appealing policy implications. These results have important policy implications, in particular in today’s world.
The current status on 3D scanning and CAD/CAM applications in textile research
Authors: Špelic Ivana 
Published: October 2019

Purpose
In order to present a significant usage of the computer-aided design (CAD)/computer-aided manufacturing (CAM) systems in the apparel and textile industry, the current literature has been observed. Although the CAD/CAM systems have also been increasingly applied to all fields apparel and textile manufacturing for the last few decades, improving the precision, productivity and the organization of the information flow, they have not been fully utilized in these industrial fields. The paper aims to discuss these issues.

Design/methodology/approach
The paper is structured in three main sections showing the vast applicability of the CAD/CAM systems, the benefits provided by them and the future trend in their development.

Findings
Although the initial development of the CAD/CAM systems strived to completely eliminate manual and time-consuming operations, they have not been accepted in practice due to their inﬂexibility at making changes and the time needed for regenerating a complex parametric model. The textile and apparel industries show slow progress in acquiring the CAD/CAM systems.

Originality/value
This CAD/CAM technology enabled the customization in the design process according to individual needs and directed the textile and the apparel industry to moving into new directions such as the mass customization to personalization. The paper makes clear that although this technological concept is rather old, the use of the CAD/CAM systems will inevitably broaden in terms of applicability to new production stages.
Economics of seismic safety for earthquake-prone Himalayan province of Uttarakhand in India
Authors: Rautela Piyoosh , Joshi Girish Chandra , Ghildiyal Shailesh 
Published: October 2019

Purpose
The purpose of this study is to estimate the cost of seismic resilience of identified vulnerable lifeline public buildings in earthquake-prone Himalayan province of Uttarakhand in India.

Design/methodology/approach
Built area of the identified vulnerable lifeline buildings together with prevalent rate of construction has been considered for assessing the cost of seismic resilience while improvised rapid visual screening (RVS) technique, better suited to the built environment in the region, has been used for assessing seismic vulnerability.

Findings
Investment of US$250.08m is assessed as being required for ensuring seismic safety of 56.3, 62.1, 52.9, 64.6, 71.9 and 61.7% surveyed buildings, respectively, of fire and emergency services, police, health, education, local administration and other departments that are to become non-functional after an earthquake and result in a major socio-political turmoil. A total amount of US$467.71m is estimated as being required for making all the buildings of these departments seismically resilient.

Research limitations/implications
Actual investment estimates and reconstruction/retrofitting plans have to be prepared after detailed investigations as RVS technique only provides a preliminary estimate and helps in prioritising buildings for detailed investigations.

Practical implications
This study is intended to provide a snapshot of the state of seismic vulnerability together with the financial resources required for corrective measures. This is to help the authorities in planning phased mobilisation of financial and technical resources for making the built environment seismically resilient.

Social implications
This study is to bring forth awareness on this important issue and consequent public opinion in favour of safety of public facilities to ensure allocation of appropriate financial resources together with changes in techno-legal regime for the cause of earthquake safety. At the same time, this study is to motivate masses to voluntarily assess safety of their neighbourhood and undertake corrective measures.

Originality/value
This study is based on primary data collected by the authors.
The individual performance outcome behind e-commerce
Authors: Tam Carlos , Loureiro Ana , Oliveira Tiago 
Published: October 2019

Purpose
While most e-commerce studies focus on the understanding of online customer behaviour, mainly adoption and purchase behaviours. The purpose of this paper is to examine the relationship between e-commerce and individual performance. The authors test the role of systems, information and service quality in e-commerce use and user satisfaction. Trust may become an important aspect for a consumer’s decision making, based on this the authors identify the effect of the role of trust on e-commerce use, user satisfaction and its impact on individual performance. This research has theoretical and managerial implications, since the protagonism of e-commerce is increasing in both academia and industry.

Design/methodology/approach
The authors apply a research model that integrates information systems success dimensions and user behaviour in the form of trust. The empirical approach was based on an online survey questionnaire of 437 individuals from Portugal.

Findings
The results reveal that overall quality and overall trust are important to explain use and user satisfaction in the context of e-commerce, which further leads to individual performance. The findings indicate that a higher level of use and user satisfaction increase individual performance.

Originality/value
The authors integrate information systems success dimensions and overall trust to understand the significance of e-commerce individual performance. The authors expect the results to enrich the understanding of the importance of considering both technological and behavioural factors to increase the success of e-commerce.
Driving innovation in supply chains: an examination of advanced manufacturing and food industries
Authors: Rampersad Giselle C. , Hordacre Ann-Louise , Spoehr John 
Published: October 2019

Purpose
The purpose of this study is to investigate how supply chains can become more resilient through innovation initiatives. It examines the expansion and deepening of relationships between buyers and suppliers and the facilitatory role of the government in this process.

Design/methodology/approach
This study compares supply chains in the advanced manufacturing and food industries. It is based on qualitative research involving case studies and in-depth interviews with buyers, suppliers and facilitators from government.

Findings
The study reveals that innovation is critical in building more resilient supply chains. It uncovers the importance of power distribution, coordination, communication, trust and commitment for innovation within these relationships.

Practical implications
It provides implications about how best to develop effective buyer–supplier relationships through innovation and diversification, for marketing and purchasing managers, CEOs of manufacturing companies and suppliers and government players with responsibility for industry development and innovation.

Originality/value
It advances the industrial buyer–supplier literature by extending the predominantly business-to-business supply chain perspective to include the role of government in supply chains and their innovation.
What drives customer satisfaction and word of mouth in mobile commerce services? A UTAUT2-based analytical approach
Authors: Kalinić Zoran , Marinković Veljko , Djordjevic Aleksandar , Liebana-Cabanillas Francisco 
Published: October 2019

Purpose
The purpose of this paper, which is based on the UTAUT2 model, is to develop and evaluate a predictive model of customer satisfaction related to mobile commerce (m-commerce) and the willingness to recommend this service to others.

Design/methodology/approach
The study was conducted based on a sample of 402 respondents. Confirmative factor analysis was used to evaluate the validity of the model, while structural equation modeling (SEM) was used to test the hypotheses. Finally, artificial neural networks were used to rank the influence of the significant predictors obtained by SEM.

Findings
Trust was found to be the most significant driver of customer satisfaction, followed by performance expectancy and perceived value. In addition, affective commitment and satisfaction were identified as the strongest predictors of word of mouth (WOM).

Originality/value
The originality/value of the paper lies in the establishment of the connection between the independent variables of the UTAUT 2 model – trust, satisfaction, affective and continence commitment and WOM. Additionally, it is one of a small number of studies investigating customer commitments and their influence on WOM in m-commerce.
Cost-effectiveness of TB treatments to Burmese and Laotian patients by Thai hospitals on the border with Myanmar and Laos
Authors: Laingoen Onn , Apidechkul Tawatchai , Upala Panupong , Tamornpark Ratipark , Foungnual Chaleerat , Paramee Rattakarn 
Published: October 2019

Purpose
The purpose of this paper is to estimate the cost-effectiveness of tuberculosis (TB) treatment and care in two Thai hospitals located on the borders with Myanmar and Laos.

Design/methodology/approach
A retrospective data collection was conducted to analyze all costs relevant to TB treatment and care from Mae Sai and Chiang Sean Hospitals. The cost related to TB treatment and care and the number of successful TB treatment from January 1 to December 31, 2017 were used for the calculation. The cost-effectiveness ratio (C/E) and the incremental cost-effectiveness ratio (ICER) were the outcomes.

Findings
In 2017, the total cost of the TB treatment and care program at Mae Sai Hospital was 482,728.94 baht for 57 TB patients. The cast per treated case per year was 8,468.93 baht. The C/E was 10,971.11 baht per successful TB treatment (44 successful cases). The total cost of the TB treatment and care program at Chiang Sean Hospital was 330,578.73 baht for 39 TB patients. The cost per treated case per year was 8,476.38 baht. The C/E was 22,038.58 baht per successful TB treatment (15 successful cases). The ICER was 5,246.56 baht. The Mae Sai Hospital model was more cost-effective in terms of the treatment and care provided to Burmese patients with TB than the Chiang Sean Hospital model for Laotian patients with TB.

Originality/value
To improve the cost-effectiveness of TB treatment and care programs for foreign patients in hospitals located on the Thai border, focus should be placed on patient follow-up at the community or village level.
Reviewing the progress of information and communication technology in the restaurant industry
Authors: Moreno Pilar , Tejada Pilar 
Published: October 2019

Purpose
The purpose of this study is to identify the progress of research of information and communication technologies (ICT) in the restaurant industry. More specifically, this paper reviews the main academic contributions from the area of hospitality and tourism over the past 18 years by addressing the adoption and implementation of ICT in restaurant activities.

Design/methodology/approach
This study analyses 68 full-length ICT research articles that were published in the period 2000-2018 in 29 journals (with Science Journal Citation Reports or Scimago Journal Rankings impact) and eight subject areas.

Findings
The review reveals a number of significant findings. It highlights the scarcity of contributions within academic research related to the area of hospitality and tourism focused on addressing the issue of ICT in restaurants. Moreover, and predictably, several dimensions clearly emerge from the consumer and supply perspectives as being the most prominent. On the one hand, the adoption of ICT has changed the behaviour of consumers in at least three dimensions: information search and evaluation of alternatives purchase decision and post-purchase behaviour. On the other hand, ICT has revolutionised the core business areas of restaurants by dramatically transforming the following areas: operational and strategic management, marketing and Web design, customer services, security, food and nutrition and human resources.

Originality/value
Given the fact that ICT in the restaurant industry remains a largely unexplored subject, this paper can offer a useful tool for researchers who pursue advances in this field, by providing an overview that outlines the main aspects that need further research.
How manufacturing firm characteristics can influence decision making for investing in Industry 4.0 technologies
Authors: Bosman Lisa , Hartman Nathan , Sutherland John 
Published: October 2019

Purpose
Investing in Industry 4.0 is an important consideration for manufacturing firms who strive to remain competitive in this global economy, but the uncertainty and complexity of where to focus technology investments is a problem facing many manufacturers. The purpose of this paper is to highlight a region of manufacturing firms in the Midwest USA to investigate the role of firm size, access to funds and industry type on decision to invest in and deploy various Industry 4.0 technologies.

Design/methodology/approach
A survey was developed, piloted, and deployed to manufacturing companies located in the Midwest USA, specifically, Indiana, USA. A total of 138 manufacturing firms completed the full survey. The survey participants were requested to rank order the various technology categories with respect to previous historical spending, workforce capabilities and anticipated return on investment. The survey was supplemented with publically available data. Due to the use of rank-order data to identify Industry 4.0 priorities, a non-parametric analysis was completed using the Kruskall Wallis test.

Findings
The findings suggest that manufacturers with less than 20 employees and/or less access to funds (sales less than $10m) prioritize digital factory floor technologies (e.g. technology directly impacting productivity, quality and safety of manufacturing processes). Larger manufacturers with 20 or more employees and/or access to more funds (sales greater than or equal to $10m) prioritize enterprise support operations technologies.

Originality/value
Research studies and reports tend to lump manufacturing’s perspective of Industry 4.0 into one homogenous group, and rarely acknowledge the limited participation of “smaller” Small and medium-sized enterprises, which account for the far majority of manufacturing firms in the USA. The value of this study is on the “novelty of approach,” in that the data collection and analysis focuses on heterogeneity of manufacturing firms with respect to size, access to funds and industry type. The findings and recommendations are beneficial and relevant to organizations supporting Industry 4.0 efforts through workforce development and economic development initiatives.
Integrating instrumental and normative stakeholder theories: a systems theory approach
Authors: Valentinov Vladislav , Hajdu Anna 
Published: October 2019

PurposeThe stakeholder theory encompasses instrumental and normative varieties whose mutual relationship remains unclear and exhibits a classic tension between rational self-interest and moral motivation. The purpose of this paper is to develop a strategy for navigating this tension.Design/methodology/approachNiklas Luhmann’s social systems theory is concerned with the limited ability of social systems to codify, and be receptive to, the complexity of the environment. Drawing on this theory, the paper juxtaposes the codification problems of two types of social systems: the for-profit firm and the economic function system.FindingsThis juxtaposition allows to identify four firm behavior patterns, two of which can be aligned with instrumental and normative stakeholder theories. If the codification capacity of the economic function system is assumed to be sufficient, the codification problems of the for-profit firm are shown to specify the range of applicability of the instrumental stakeholder theory. Dropping the above assumption is shown to specify the range of applicability of the normative stakeholder theory.Originality/valueThe argument offers a fresh way of understanding the institutional economics foundations of the stakeholder theory. Given that the systems-theoretic idea of codification reflects the functioning of the real-world institutions, the argument shows that both instrumental and normative stakeholder theories reflect the institutional texture of the modern society in distinct but equally legitimate ways.
Leaf resistance traits influence endophytic fungi colonization and community composition in a South American temperate rainforest
Authors: González‐Teuber Marcia , Vilo Claudia , Guevara‐Araya María José , Salgado‐Luarte Cristian , Gianoli Ernesto 
Published: October 2019

Abstract

Despite the ubiquitous presence of fungal endophytes in woody plants, mechanisms underlying variation in foliar fungal endophyte communities are poorly understood. Given that endophytes in woody plants are predominantly horizontally transmitted, fungal endophyte colonization of foliar tissues is likely to be influenced by plant resistance traits. Here, we evaluated the association between leaf resistance traits and colonization and community composition of horizontally transmitted endophytes (HTE) in 10 dominant trees species in a temperate rainforest in Southern Chile. Because resistance traits might restrict colonization of HTE, it was hypothesized that host trees with similar leaf resistance traits would show similar HTE communities.

We measured leaf traits with reported roles in plant resistance against pathogens and/or herbivores: cell wall polysaccharides, leaf toughness, flavonoids, anthocyanins, terpenoids and chitinases. We also determined variation in fungal read counts, number of operational taxonomic units (OTUs), diversity and community structure across tree species. Foliar fungal endophyte communities were characterized using Illumina MiSeq sequencing of tagged amplicons of the ITS1 region.

Fungal read counts were significantly different among host trees, while number of OTUs and diversity were similar among them. Multivariate analyses showed that community composition of endophytic fungi significantly differed among hosts, and that variation in cell wall, flavonoids, anthocyanins and terpenoids was associated with differences in HTE communities. We found that host trees sharing leaf resistance traits harbour similar HTE communities. Fungal read counts decreased with increasing content of cell wall polysaccharides, while endophyte diversity decreased with increasing anthocyanin levels. Fungal read counts, in contrast, were positively associated with terpenoids. Additionally, culture‐based data indicated that some HTE strains inhibited the growth of the common fungal pathogen Botrytis cinerea.

Synthesis. Overall, we found that leaf resistance traits may influence fungal endophyte colonization and community composition in tree species, likely through deterrent effects of structural and chemical traits. We suggest that endophytic fungi that overcome resistance traits might play a role in plant protection.