bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frontal Hemodynamic Response During Step Initiation Under Cognitive Conflict in Older and Young Healthy People
Authors: Coelho Daniel Boari , Bazán Paulo Rodrigo , Zimeo Morais Guilherme Augusto , Balardin Joana Bisol , Batista Alana Xavier , de Oliveira Claudia Eunice Neves , Los Angeles Emanuele , Bernardo Claudionor , Sato João Ricardo , de Lima-Pardini Andrea C 
Published: May 2020

AbstractGait initiation is a daily challenge even for healthy individuals as it requires the timely coupling between the automatic anticipatory postural adjustment (APA) and the voluntary step according to the context. Modulation of this motor event has been thought to involve higher level brain control, including cognitive inhibitory circuitries. Despite the known participation of the supplementary motor area (SMA) in the modulation of some parameters of APA, the participation of areas controlling inhibition during gait initiation still needs to be investigated. In this study, the hemodynamic responses of the SMA and dorsolateral prefrontal cortex (DLPFC) were assessed using functional near-infrared spectroscopy (fNIRS) during a gait initiation task under cognitive conflict to select the foot to step (congruent [CON] and incongruent [INC] conditions). The older group (OG) showed worse inhibitory control than the young group (YG) along with more impairments in APA parameters. OG also had a lower amplitude of hemodynamic responses in both areas than YG in the INC. The INC increased the correlation between SMA and DLPFC only in the YG. Aging seems to impair the interaction between the hemodynamic responses of SMA and DLPFC, which influences APA performance in gait initiation under cognitive conflict.
The Role of Citrullination in Inflammatory Bowel Disease: A Neglected Player in Triggering Inflammation and Fibrosis?
Authors: Dragoni Gabriele , De Hertogh Gert , Vermeire Séverine 
Published: May 2020

Abstract
Citrullination is a posttranslational modification of proteins mediated by a specific family of enzymes called peptidylarginine deiminases (PAD). Dysregulation of these enzymes is involved in the etiology of various diseases, from cancer to autoimmune disorders.
In inflammatory bowel disease (IBD), data for a role of citrullination in the disease process are starting to accumulate at different experimental levels including gene expression analyses, RNA, and protein quantifications. Most data have been generated in ulcerative colitis, but data in Crohn disease are lacking so far.
In addition, the citrullination of histones is the fundamental process promoting inflammation through the formation of neutrophil extracellular traps (NETs). Interestingly, NETs have also been shown to activate fibroblasts into myofibroblasts in fibrotic interstitial lung disease. Therefore, citrullination merits more thorough study in the bowel to determine its role in driving disease complications such as fibrosis.
In this review we describe the process of citrullination and the different players in this pathway, the role of citrullination in autoimmunity with a special focus on IBD, the emerging role for citrullination and NETs in triggering fibrosis, and, finally, how this process could be therapeutically targeted.
From Hierarchical to Relative Hyperbolicity
Authors: Russell Jacob 
Published: May 2020

Abstract
We provide a simple, combinatorial criteria for a hierarchically hyperbolic space to be relatively hyperbolic by proving a new formulation of relative hyperbolicity in terms of hierarchy structures. In the case of clean hierarchically hyperbolic groups, this criteria characterizes relative hyperbolicity. We apply our criteria to graphs associated to surfaces and prove that the separating curve graph of a surface is relatively hyperbolic when the surface has zero or two punctures. We also recover a celebrated theorem of Brock and Masur on the relative hyperbolicity of the Weil–Petersson metric on Teichmüller space for surfaces with complexity three.
Effects of Ground Transport in Kemp’s Ridley (Lepidochelys kempii) and Loggerhead (Caretta caretta) Turtles
Authors: Hunt K E , Merigo C , Burgess E A , Buck C Loren , Davis D , Kennedy A , Lory L , Wocial J , McNally K , Innis C 
Published: May 2020

SynopsisMany juvenile Kemp’s ridley (Lepidochelys kempii) and loggerhead (Caretta caretta) turtles strand during fall on the beaches of Cape Cod (MA, USA), with total stranding numbers sometimes exceeding 300 turtles per year. Once rehabilitated, turtles must be released at beaches with appropriate water temperatures, often requiring transportation to southeastern coastal states of the USA. These transportation events (transports) may approach or exceed 24 h in duration. Kemp’s ridley turtles are known to exhibit an adrenal stress response during such transports, but the effect of transport duration has been unclear, and no other sea turtle species has been investigated. To assess whether transport duration and/or species affects physiological reactions to transport, we studied pre- and post-transport physiological measures in Kemp’s ridley and loggerhead turtles transported by ground for &lt;6, ∼12, ∼18, or ∼24 h, comparing with matched “control events” in which turtles were studied without transport. Blood samples were analyzed for four stress-associated measures (corticosterone, glucose, total white blood cell [WBC] count, and heterophil/lymphocyte ratio [H/L]) and nine measures of clinical status (pH, pO2, pCO2, HCO3, sodium, potassium, ionized calcium, lactate, and hematocrit). In both species, stress-associated measures elevated significantly during transport, while handling without transport had no significant effects. Loggerheads exhibited a greater stress response than Kemp’s ridleys across all transport durations. These results indicate that sea turtles do react physiologically to ground transport; therefore, minimizing transport time and streamlining transport logistics (where feasible) may help ensure release of rehabilitated turtles to sea in the best possible condition. Nonetheless, both species remained in good clinical condition even after 24 h transport, indicating that current transport protocols are generally safe for sea turtles from a clinical perspective.
Heat stress-induced deficits in growth, metabolic efficiency, and cardiovascular function coincided with chronic systemic inflammation and hypercatecholaminemia in ractopamine-supplemented feedlot lambs
Authors: Swanson Rebecca M , Tait Richard G , Galles Beth M , Duffy Erin M , Schmidt Ty B , Petersen Jessica L , Yates Dustin T 
Published: May 2020

Abstract
Heat stress hinders growth and well-being in livestock, an effect that is perhaps exacerbated by the β1 agonist ractopamine. Heat stress deficits are mediated in part by reduced feed intake, but other mechanisms involved are less understood. Our objective was to determine the direct impact of heat stress on growth and well-being in ractopamine-supplemented feedlot lambs. Commercial wethers were fed under heat stress (40 °C) for 30 d, and controls (18 °C) were pair-fed. In a 2 × 2 factorial, lambs were also given a daily gavage of 0 or 60 mg ractopamine. Growth, metabolic, cardiovascular, and stress indicators were assessed throughout the study. At necropsy, 9th to 12th rib sections (four-rib), internal organs, and feet were assessed, and sartorius muscles were collected for ex vivo glucose metabolic studies. Heat stress increased (P &lt; 0.05) rectal temperatures and respiration rates throughout the study and reduced (P &lt; 0.05) weight gain and feed efficiency over the first week, ultrasonic loin-eye area and loin depth near the end of the study, and four-rib weight at necropsy. Fat content of the four-rib and loin were also reduced (P &lt; 0.05) by heat stress. Ractopamine increased (P &lt; 0.05) loin weight and fat content and partially moderated the impact of heat stress on rectal temperature and four-rib weight. Heat stress reduced (P &lt; 0.05) spleen weight, increased (P &lt; 0.05) adrenal and lung weights, and was associated with hoof wall overgrowth but not organ lesions. Ractopamine did not affect any measured indicators of well-being. Heat stress reduced (P &lt; 0.05) blood urea nitrogen and increased (P &lt; 0.05) circulating monocytes, granulocytes, and total white blood cells as well as epinephrine, TNFα, cholesterol, and triglycerides. Cortisol and insulin were not affected. Heat stress reduced (P &lt; 0.05) blood pressure and heart rates in all lambs and increased (P &lt; 0.05) left ventricular wall thickness in unsupplemented but not ractopamine-supplemented lambs. No cardiac arrhythmias were observed. Muscle glucose uptake did not differ among groups, but insulin-stimulated glucose oxidation was reduced (P &lt; 0.05) in muscle from heat-stressed lambs. These findings demonstrate that heat stress impairs growth, metabolism, and well-being even when the impact of feed intake is eliminated by pair-feeding and that systemic inflammation and hypercatecholaminemia likely contribute to these deficits. Moreover, ractopamine improved muscle growth indicators without worsening the effects of heat stress.
In silico validation of pooled genotyping strategies for genomic evaluation in Angus cattle
Authors: Alexandre Pâmela A , Reverter Antonio , Lehnert Sigrid A , Porto-Neto Laercio R , Dominik Sonja 
Published: May 2020

Abstract
In this study, we aimed to assess the value of genotyping DNA pools as a strategy to generate accurate and cost-effective genomic estimated breeding values (GEBV) of sires in multi-sire mating systems. In order to do that, we used phenotypic records of 2,436 Australian Angus cattle from 174 sires, including yearling weight (YWT; N = 1,589 records), coat score (COAT; N = 2,026 records), and Meat Standards Australia marbling score (MARB; N = 1,304 records). Phenotypes were adjusted for fixed effects and age at measurement and pools of 2, 5, 10, 15, 20, and 25 animals were explored. Pools were created either by phenotype or at random. When pools were created at random, 10 replicates were examined to provide a measure of sampling variation. The relative accuracy of each pooling strategy was measured by the Pearson correlation coefficient between the sire’s GEBV with pooled progeny and the GEBV using individually genotyped progeny. Random pools allow the computation of sire GEBV that are, on average, moderately correlated (i.e., r &gt; 0.5 at pool sizes [PS] ≤ 10) with those obtained without pooling. However, for pools assigned at random, the difference between the best and the worst relative accuracy obtained out of the 10 replicates was as high as 0.41 for YWT, 0.36 for COAT, and 0.61 for MARB. This uncertainty associated with the relative accuracy of GEBV makes randomly assigning animals to pools an unreliable approach. In contrast, pooling by phenotype allowed the estimation of sires’ GEBV with a relative accuracy ≥ 0.9 at PS &lt; 10 for all three phenotypes. Moreover, even with larger PS, the lowest relative accuracy obtained was 0.88 (YWT, PS = 20). In agreement with results using simulated data, we conclude that pooling by phenotype is a robust approach to implementing genomic evaluation using commercial herd data, and PS larger than 10 individuals can be considered.
The Artificial Sweetener, Erythritol, Has Insecticidal Properties Against Pear Psylla (Hemiptera: Psyllidae)
Authors: Wentz Katie , Cooper W Rodney , Horton David R , Kao Robert , Nottingham Louis B 
Published: May 2020

Abstract
Erythritol is a dietary sweetener that is used for low-calorie or diabetic diets. Although safe for human consumption, erythritol is lethal to certain Dipteran pests, but insecticidal effects of erythritol on phloem-feeding insects have yet to be examined. Our goal was to determine whether erythritol has insecticidal activity against pear psylla, Cacopsylla pyricola (Foerster) (Hemiptera: Psyllidae). We first demonstrated that ingestion of erythritol solutions compared with water by pear psylla caused reduced feeding, impaired motor functions, and reduced survival time of adults. We then tested whether foliar treatment of pear leaves with erythritol was also lethal to pear psylla. Foliar treatment of erythritol led to reduced 3-d survival of pear psylla nymphs and adults, and reduced rates of oviposition by pear psylla adults. Psylla adults also preferred to settle on untreated leaves than on erythritol-treated leaves in preference assays. Finally, we conducted field experiments to test whether applications of erythritol provided pear trees with protection against pear psylla under natural field conditions. Those experiments showed a reduction in pear psylla nymphs on erythritol-treated trees compared with untreated trees, but only if the erythritol was completely dissolved into solution by heating. Laboratory trials confirmed the importance of heating. Results of our experiments demonstrate that erythritol is insecticidal to pear psylla nymphs and adults and provide the first report that erythritol is lethal to a phloem-feeding insect. These findings suggest that erythritol may provide a new safe and effective tool for the management of pear psylla.
The effects of the COVID-19 pandemic on oncological surgery
Authors: Kling Sarah M , Philp Matthew M 
Published: May 2020

Abstract
The COVID-19 global pandemic is changing the practice of oncologic surgery. Accustomed to fighting cancer with all available means, surgeons are now being asked to delay treatment or make use of alternate strategies to conserve resources. Telemedicine is being widely employed. We present our thoughts on this topic and where we might be in the next several months.
Auxin-mediated responses under salt stress: from developmental regulation to biotechnological applications
Authors: Ribba Tomas , Garrido-Vargas Fernanda , O’Brien José Antonio 
Published: May 2020

AbstractAs sessile organisms, plants are exposed to multiple abiotic stresses commonly found in nature. To survive, plants have developed complex responses that involve genetic, epigenetic, cellular, and morphological modifications. Among different environmental cues, salt stress has emerged as a critical problem contributing to yield losses and marked reductions in crop production. Moreover, as the climate changes, it is expected that salt stress will have a significant impact on crop production in the agroindustry. On a mechanistic level, salt stress is known to be regulated by the crosstalk of many signaling molecules such as phytohormones, with auxin having been described as a key mediator of the process. Auxin plays an important role in plant developmental responses and stress, modulating a complex balance of biosynthesis, transport, and signaling that among other things, finely tune physiological changes in plant architecture and Na+ accumulation. In this review, we describe current knowledge on auxin’s role in modulating the salt stress response. We also discuss recent and potential biotechnological approaches to tackling salt stress.
Dasypus sabanicola (Cingulata: Dasypodidae)
Authors: Chacón-Pacheco Julio , Aya-Cuero Carlos , Anacleto Teresa Cristina S 
Published: May 2020

Abstract
Dasypus sabanicola Mondolfi, 1968, commonly known as Llanos long-nosed armadillo, is the second smallest armadillo of the genus Dasypus. It is a diurnal-nocturnal insectivorous species endemic to the Orinoco Region of Colombia and Venezuela, where it inhabits natural savannas and riparian forests. D. sabanicola is listed as “Near Threatened” by the International Union for Conservation of Nature and Natural Resources due to its restricted distribution to the floodplains (llanos), an ecosystem that is severely affected by continuing habitat conversion. It is also hunted in several parts of its range.
Ocular Actinomycosis Mimicking Meningioma
Authors: Kobayashi Takaaki , Ford Bradley , Fujita Nobuhiro , Appenheimer A Ben 
Published: May 2020

Abstract
Orbital actinomycosis is an unusual clinical manifestation of orbital infection caused by Actinomyces species. Herein we report a case of orbital actinomycosis in a 67-year-old woman with recurrent swelling and erythema around her left eye with an orbital mass initially thought to be a meningioma.
On Frege’s Assimilation of Sentences with Names*
Authors: Kim Dongwoo 
Published: May 2020

Abstract
I shall discuss some of the issues concerning a notorious doctrine of Frege that sentences are names of truth-values. I am interested in a problem raised by Kripke that the doctrine obscures the distinction between judgeable and unjudgeable contents. I shall present what I take to be Frege’s account of judgeable content: a proper expression of a judgeable content is susceptible to an analysis into a predicate and an argument-word, where a predicate is understood as a concept-word used to attribute a certain property to the referent of the argument-word. In the light of this analysis, I shall argue that the doctrine does not obscure the distinction. The problem will also be discussed within the formal context of Grundgesetze. A new light will be shed on his rather peculiar conception of the symbol ‘ ${\boldsymbol \vdash}$’.
Role of Magnetic Resonance Imaging in Evaluation Of Anterior Knee Pain
Authors: Abbas Y A , Abdulkhalik Y I , Motlaq Y H 
Published: May 2020

Abstract

Background
The knee joint is one of the most commonly injured joints in the body. Because of its complex structure, this joint is subjected to numerous pathologies and due to the recent increase in various sport activities, there has been a parallel increase in sport-induced internal derangements of the knee. The main strength of knee MRI is the assessment of articular and Peri-articular diseases. The specific structures best suited for MRI assessment include tendons, muscles and ligaments, as well as peri-articular soft tissue masses.

Objective
The purpose of this study is to detect the accuracy of MR imaging as a diagnostic tool in the evaluation of different knee joint pathologies that cause anterior knee pain, with emphasis on some of their grades and types for better assessment.

Methodology
This study included 20 patients (6 female and 14 male). Their ages range between 10-60 years (average age 30 years). All presented by anterior knee pain and were referred to radiology department of Ain Shams University hospital or private centers for MRI examination after orthopedic consultation.

Results
5% of the patients presented with anterior knee pain showed MRI evidence of patellar tendinopathy (66% below the age of 30 years and more in females). In all cases the hyperintense focal thickening was at the proximal third of the tendon, with the AP diameter of the patellar tendon greater than 8mm. In our results about 10% of the patients in the study sample, had MRI evidence of tear in the anterior horn of lateral knee meniscus with a female equal to male (50% females and 50% males). Cartilage injuries were detected in 5% of the study sample, showing male predominance (100% were male and 0% were female) with average age 32 years. All have a past history of trauma.

Conclusion
MRI is generally safe, accurate, and specific modality which has been proven to be the modality of choice in the diagnosis of different knee pathologies that cause anterior knee pain in different age groups. Also, it has a high specification in detecting the grades and types of some of these diseases.
Utility of C-Arm CT in Detection Hepatocellular Carcinoma during Trans Arterial Chemoembolization
Authors: Ghazy M S , Soliman A H , Abdelmaksoud M H K , Morsy N M E 
Published: May 2020

Abstract

Background
Transcatheter arterial chemoembolization is one of the effective therapeutic options for hepatocellular carcinoma (HCC). Ultraselective chemoembolization is an alternative approach to improve local control, and is associated with a reduced incidence of adverse effects.

Objective
It was to evaluate the sensitivity of cone beam computed tomography (CBCT) in detecting HCC tumors and their feeding vessels during transarterial chemoembolization (TACE).

Patients and Methods
All patients were suspected of having or confirmed to have HCC on the basis of clinical history, underlying liver disease and/or viral infection, the diagnosis of HCC was made by imaging findings. Between January 2016 and January 2018, Dyna CT was retrospectively used in 19 consecutive patients with HCC tumor with HCC tumor.

Results
The detectability of the tumor with DSA obtained at the common, proper, right, or left hepatic artery (i.e., nonselective DSA) and cone-beam CT was compared as taking pre imaging as a gold standard. Tumor stain and feeding branches were evaluated. The detectability of the tumor-feeding branch with non-selective DSA and Dyna CT HA images was compared.

Conclusion
Tumor detectability on cone-beam CT was significantly greater than on non-selective. Cone beam HA taking pre imaging as a gold standard was (94.4%) and its specificity (71.6%) with accuracy (76.97%). The sensitivity of DSA in detection of additional tumor as taking the pre imaging (CT/MRI) as a gold standard was (88.9%) and its specificity (84.5%) with accuracy (85.53%). Cone-beam CT has satisfactory ability to detect tumors; the detectability of tumor-feeding branches with Dyna CT was significantly higher than that with nonselective DSA (P less than 0.001). We believe the technical success rates of ultraselective transcatheter arterial chemoembolization may be improved by chemoembolization guidance software that uses cone-beam CT technology.
T77. ASSOCIATION BETWEEN INTRACELLULAR INFECTIOUS AGENTS AND SCHIZOPHRENIA
Authors: Kwon Young-Joon , Yoon Bo-Hyun , Lee Kwanghun , Kim Moon-Doo , Nam Beomwoo , Shim Se-Hoon , Lim Eunsung 
Published: May 2020

Abstract

Background
A number of studies have reported association between Toxoplasma gondii (T. gondii) and Chlamydia infection and the risk of schizophrenia. The aim of the present study was to compare the prevalence of T. gondii and Chlamydia infection between the schizophrenia and normal control subjects and to compare the clinical features between seropositive and seronegative schizophrenia patients.

Methods
The rate of serum reactivity to T. gondii, Chlamydia trachomatis (C. trachomatis), Chlamydia pneumonia in 96 schizophrenia and 50 control subjects was investigated using enzyme-linked immunosorbent assay and indirect fluorescent antibody technique. The clinical symptoms of the schizophrenia patients were scored with Positive and Negative Syndrome Scale and a comparative analysis was carried out.

Results
A significant positive association between immunoglobulin G (IgG) antibodies to T. gondii and C. trachomatis in schizophrenia was found, and the odds ratio of schizophrenia associated with IgG antibody was found to be 3.22 and 2.86, respectively. The Toxoplasma-seropositive schizophrenia patient had higher score on the negative subscale N1 and N7 and general psychopathology subscale G13, while C. trachomatis-seropositive schizophrenia patient had higher score on the general psychopathology subscale G10.

Discussion
The results from the present study suggest significant association between T. gondii, C. trachomatis infection and schizophrenia. In future, further studies are needed to elucidate the correlation between the two types of infection and schizophrenia.