bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proyectos de arte de acción: análisis de una experiencia pedagógica
Authors: Tejo-Veloso Carlos 
Published: January 2020

Tras seis años de docencia continuada en la asignatura Proyectos de Arte de Acción, proponemos ahora un artículo que analice esta materia ofertada dentro del plan de estudios del grado en Bellas Artes de la Universidad de Vigo. Para ello estudiaremos el contexto de la enseñanza del arte de acción en la universidad española, la tipología de arte de acción que ocupa nuestra práctica pedagógica, el tejido académico que rodea nuestra docencia, la demanda de la asignatura entre los estudiantes, la guía docente, el perfil de nuestro alumnado, la metodología docente empleada y las características esenciales de la evaluación.
Fitzgerald's High IQ: An Interview with Colonel Benjamin W. Venable, 45th Regiment, U.S. Army
Authors: Elmore A. E. 
Published: January 2020

Abstract
This interview was conducted in 1973 with Colonel Benjamin Wilson Venable (1894–1980), who served as a captain in the same 45th Regiment in which F. Scott Fitzgerald was a lieutenant. Venable's lively recollections of Fitzgerald and Zelda Sayre in Camp Sheridan outside Montgomery, Alabama, offer insight into daily life and military protocol at the time; his claim that Fitzgerald ranked highest in IQ in the regiment helps substantiate the belief that Fitzgerald's intelligence has been highly underrated—something as true today as it was during the years Elmore spent working on his book-length study of The Great Gatsby from which this is an excerpt. It is published with the permission of both the Elmore and Venable families. We also thank John Kuhnle for his work on the manuscript.
Botrys neboli esej o záludnostech historikovy práce (rozprava o metodě)
Authors: Vykoupil Libor 
Published: January 2020

The elder and more experienced certainly know or at least have a vague idea that there used to be a Greek brandy named Botrys containing 40 % of alcohol. Its name was probably derived from the name of Botrytis cinerea (botrytis bunch rot, more commonly). The Greek term is Βότρυς and its transcription into Latin alphabet is Votrus or Votris. However, if a scholar attempts to verify in such an elementary finding, they can get entangled in very complex and tricky historical facts. After weeks of hard work it turned out that it is probably easier to write a chapter on the history of Greek economy of the second half of 19th century than a few lines on a distillery producing a brandy called Botrys. And so this contribution somehow by the way describes a solution to the „raisin problem“ in order to conclude with some basic information on the label Botrys.
Conectando testamentos: Números como tipo en Biblia Pauperum y Speculum Humanae Salvationis / Connecting Testaments: Numbers as Type in the Biblia Pauperum and the Speculum Humanae Salvationis
Authors: Azanza López José Javier 
Published: January 2020

ABSTRACT: In the close typological relationship established in the Middle Ages between the Old and New Testaments, the Book of Numbers becomes an exemplary Christological and Mariological prefigurative example. The episodes of the Murmuring of Miriam and Aaron, the Spies from Canaan, the Rebellion of Korah, Dathan, and Abiram, the Brazen Serpent, the Budding of Aaron’s Rod and the Prophecy of Balaam, constitute types of New Testament passages collected in the Biblia Pauperum and the Speculum Humanae Salvationis, whose repercussion will be felt in Medieval and Modern Art as a theological visual synthesis present in stained glass windows, sculptures of portals, tapestries, goldsmith works and altarpieces.
KEYWORDS
Book of Numbers; Typological Method; Biblia Pauperum; Speculum Humanae Salvationis; Medieval and Modern Art.
RESUMEN: En la estrecha relación tipológica establecida en la Edad Media entre Antiguo y Nuevo Testamento, el libro de los Números se convierte en exepcional ejemplo prefigurativo cristológico y mariológico. Los episodios de la murmuración de Miriam y Aarón, los exploradores de Canaán, la rebelión de Coré, Datán y Abirón, Moisés y la serpiente de bronce, la vara florida de Aarón y la profecía de Balaam, constituyen otros tantos tipos anunciadores de pasajes neotestamentarios recogidos en Biblia Pauperum y Speculum Humanae Salvationis, cuyo eco se dejará sentir en el arte medieval y moderno como síntesis visual teológica plasmada en vidrieras, portadas, tapices, piezas de plata y retablos.
Moderation effects of food intake on the relationship between urinary microbiota and urinary interleukin-8 in female type 2 diabetic patients
Authors: Liu Fengping , Ling Zongxin , Tang Chulei , Yi Fendi , Chen Yong Q. 
Published: January 2020

Background
Our previous study demonstrated that the composition of the urinary microbiota in female patients with type 2 diabetes mellitus (T2DM) was correlated with the concentration of urinary interleukin (IL)-8. As the composition of urine is mainly determined by diet, diet might mediate the correlation.

Methods
Seventy female T2DM patients and 70 healthy controls (HCs) were recruited. Midstream urine was used for the urine specimens. Urinary IL-8 was determined by enzyme-linked immunosorbent assay. A Chinese Food Frequency Questionnaire was used to collect food intake data. The independent variables in the hierarchical regression analysis were the relative abundances of the bacterial genera and species that were significantly different between the T2DM and HCs and between the T2DM patients with and without detectable urinary IL-8, and the bacterial genera associated with IL-8 concentration in the multiple regression model reported in our previous research. IL-8 concentration was the dependent variable, and nutrient intakes were moderator variables.

Results
Fiber and vitamin B3 and E intake exerted enhancing effects, and water intake exerted a buffering effect, on the positive relationship between the relative abundance of Ruminococcus and IL-8 concentration (p < 0.05). Cholesterol and magnesium intake exerted enhancing effects on the positive relationship between the relative abundance of Comamonas and IL-8 concentration (p < 0.05).

Conclusion
Modulating T2DM patients’ dietary patterns may prevent bladder inflammation.
HIV Disclosure in Children in This Millenium – Should It still be an Issue?
Authors: U. Eneh A. , O. Ugwu R. , I. Paul N. 
Published: January 2020

Background: As more children with HIV survive into adolescence and adulthood, one of the most difficult issues that families with HIV-infected children face is disclosure of their children’s status to them.
Objective: To explore factors associated with disclosure or none disclosure and whether disclosure is beneficial or not.
Methods: The mothers of HIV positive children who brought their children aged 5-18 years to the Paediatric Infectious Disease Clinic of the University of Port Harcourt Teaching Hospital from January to December 2015 were interviewed using a structured investigator administered questionnaire.
Results: Of the 100 caregivers interviewed, 26.0% have disclosed the HIV status to the children. The mean age at disclosure was 14.42 ± 2.45 years. Care givers that have disclosed were significantly older (45.58±8.32 years vs 38.18±9.2 years; p = .0002). The mean age of children whose status have been disclosed was significantly higher than those who were yet to be aware of their status (14.42±2.45years vs 10.97±3.11 years; p = 0.00001). There was no significant difference in the mode of transmission and orphan status between the two groups. Disclosure was significantly more among children who were diagnosed between 5-10 years of age (14; 53.8%) (p=0.013), have taken antiretroviral drugs for over 24 months (22; 84.6%) (p= 0.003) and had at least one HIV-infected sibling (21; 80.8%) (p=0.00001). Among 13 (50.0%) whose status have been disclosed and 59 (79.7%) whose status had not been disclosed, the caregiver had disclosed the child’s status to others (p= 0.004). The major reason for disclosing was because the child was either asking questions on why he/she is taking drugs or he/she is refusing to take drugs (15; 57.7%) respectively. Only 6 (23.1%) caregivers disclosed because they felt the child has a right to know. Most difficult question asked by the children during disclosure was how they got the HIV (22; 84.6%). Reasons given for non-disclosure included fear of disclosure to others (74; 100%), child too young to understand (70; 94.5%) and fear of impact on child’s emotional health (42; 56.7%). Majority 20 (76.9%) of the care givers felt relieved after disclosure. Twenty-four (92.3%) caregivers felt disclosure had improved child’s adherence to antiretroviral therapy and determination to survive (22; 84.6%).
Conclusion: Disclosure is beneficial to both the child and caregiver. Healthcare providers should encourage caregivers to disclose HIV status to their children as soon as possible.
Determinants of Quality of Life among Menopausal Market Women Traders in a South-Western Town, Nigeria
Authors: Adekunbi Farotimi Abosede , Olufunke Akinbade Musiliat , Ogba Okueso Grace 
Published: January 2020

Menopause marks the end of a woman’s reproductive life with associated physical, social, mental and cultural changes. Menopausal symptoms are known to impair the quality of life (QoL) of women. This study assessed the determinants of quality of life among menopausal women traders in a South-Western Town, Nigeria.
Methodology: This study adopted descriptive research design. 421 respondents were purposively selected based on inclusion and exclusion criteria. Standardized Structured Questionnaire that was pretested and validated was used to collect data. The data obtained were analyzed using the statistical package for the social sciences (SPSS) version 23 and P-value were set as 0.05.
Results: Socio-demographic characteristics distribution of respondents showed that 286 respondents (67.9%) were married; 205 respondents (48.7%) were secondary school holders and the menopausal mean age was 48.45±3.78 years. On determinants of QoL, 328 respondents (78.0%) reported good sleep; 301 respondents (71.5%) reported good memory; 138 respondents (32.8%) reported enjoyment of love life; and 215 respondents (51.0%) claimed to work actively. On the overall QoL 223 respondents (53.0%) experienced fair QoL; there is no significant relationship between QoL and selected demographic variables, their P value were, age = 0.48, number of children = 0.13, educational qualification = 0.70, occupation = 0.20 and monthly income = 0.53.
Conclusion: The study concluded that respondents’ love life has the least reported response among the determinants, and little above half has fair QoL. Therefore public health practitioners need to pay special attention to comprehensive sexuality education for menopausal women to improve their QoL.
Oncology Clinical Trial Design Planning Based on a Multistate Model That Jointly Models Progression‐Free and Overall Survival Endpoints
Authors: Erdmann Alexandra , Beyersmann Jan , Rufibach Kaspar 
Published: December 2024

ABSTRACTWhen planning an oncology clinical trial, the usual approach is to assume proportional hazards and even an exponential distribution for time‐to‐event endpoints. Often, besides the gold‐standard endpoint overall survival (OS), progression‐free survival (PFS) is considered as a second confirmatory endpoint. We use a survival multistate model to jointly model these two endpoints and find that neither exponential distribution nor proportional hazards will typically hold for both endpoints simultaneously. The multistate model provides a stochastic process approach to model the dependency of such endpoints neither requiring latent failure times nor explicit dependency modeling such as copulae. We use the multistate model framework to simulate clinical trials with endpoints OS and PFS and show how design planning questions can be answered using this approach. In particular, nonproportional hazards for at least one of the endpoints are a consequence of OS and PFS being dependent and are naturally modeled to improve planning. We then illustrate how clinical trial design can be based on simulations from a multistate model. Key applications are coprimary endpoints and group‐sequential designs. Simulations for these applications show that the standard simplifying approach may very well lead to underpowered or overpowered clinical trials. Our approach is quite general and can be extended to more complex trial designs, further endpoints, and other therapeutic areas. An R package is available on CRAN.
Monitoring Addiction to Pregabalin in Northern Algeria by Using Hair Testing
Authors: Soumia Tehami , Anna Bertaso , Matilde Murari , Rachid Djafer , Bortolotti Federica , Rossella Gottardo 
Published: December 2024

ABSTRACTPregabalin (PGB) is a novel gamma‐aminobutyric acid analog that has been recently approved for the treatment of partial‐onset seizures, neuropathic pain, and fibromyalgia. Although PGB presents a low potential for abuse in comparison to other scheduled drugs, the literature reports its potential misuse, especially among individuals with former or current drug addiction. The present study aimed to develop and validate a novel method for the determination of PGB in hair to perform a retrospective observational study on the misuse of this drug in a population of addicted subjects from Northern Algeria. Hair and urine samples were collected from patients (n = 79) with a history of illicit drug use, monitored by the Intermediate Addiction Care Center of Constantine (Algeria). None of the patients had a medical prescription for PGB. Samples had also been tested for the presence of other drugs of abuse with routine LC–MS/MS methods. Hair samples (∼25 mg) were analyzed for PGB after sonication for 2 h in acetonitrile. The organic phase was dried and reconstituted in 100 µL mobile phase and analyzed by LC–MS/MS. The method was fully validated with LOD and LOQ results of 10 and 20 pg/mg, respectively. The linearity was verified in the 20–1000 pg/mg range. PGB was found in the hair samples of 51/79 subjects, with concentrations ranging from traces to 380 pg/mg. The study revealed that about 65% of the subjects used PGB in the absence of any medical prescription, indicating the potential misuse of this drug.
Correlation between perinatal abnormalities and decreased fetal movement as counted by a fetal movement acceleration measurement recorder: A prospective cohort study
Authors: Ryo Eiji , Kamata Hideo , Yatsuki Keita 
Published: December 2024

AbstractObjectiveThe objective was to study the relationship between a decrease in gross fetal movement during maternal night sleep counted by an objective method and abnormal perinatal outcomes.MethodsThis was a prospective cohort study. A total of 470 pregnant women recorded fetal movement with the fetal movement acceleration measurement recorder weekly after 28 weeks. The ratio of 10‐s epochs with fetal movement to all epochs was calculated as the fetal movement parameter. When the parameter was below the 10th percentile of the previously made reference curve, it was defined as decreased movement. Women who showed a decreased movement at least once were classified into a study group, and the other women were classified into a control group. Abnormal perinatal outcomes between the two groups were compared with the Chi‐square test.ResultsThere were more preterm births (19%) in the study group than in the control group (10%) (P = 0.0210). There was a significant difference for iatrogenic preterm birth (P = 0.0241) but not for spontaneous preterm birth (P = 0.4566). There were more hypertensive disorders of pregnancy (11.6%), small‐for‐gestational‐age newborns (10.7%), and Apgar scores below 7 points at 1 min (7.4%) in the study group than in the control group (5.2%, 4.8%, and 2.6%, respectively) (P = 0.0329, 0.0459, and 0.0487, respectively).ConclusionA decrease in gross fetal movement during maternal night sleep was related to iatrogenic preterm births, small‐for‐gestational‐age newborns, hypertensive disorders of pregnancy, and low Apgar scores at 1 min.
A severe case of the bladder inversion treated by total cystectomy and hysterectomy with ileal conduit
Authors: Akai Taro , Kawamorita Naoki , Shiraiwa Tetsuro , Watanabe Mahoro , Sato Tomonori , Sato Takuma , Yokoyama Emi , Ishibashi Masumi , Watanabe Zen , Ito Akihiro 
Published: December 2024

IntroductionFemale pelvic organ prolapse (POP) is considered a borderline disease between urology and gynecology and is treated by reconstructive surgery, which restores the organs to their original positions.Case presentationAn 82‐year‐old woman with bladder and uterine prolapse at POP‐Q Stage IV was treated with an indwelling catheter for voiding dysfunction. Eventually, the catheter has been often spontaneously removed when pelvic organ prolapse occurs, resulting in a diagnosis of bladder inversion. Because of bladder inversion and low bladder capacity at the time of bladder retraction, the patient underwent total cystectomy, combined with total hysterectomy, colpopexy, and posterior colporraphy, and ileal conduit.ConclusionThe cases of complete bladder and uterine prolapse combined with bladder inversion, total hysterectomy, colpopexy, posterior colporraphy, and ileal conduit were performed safely. Considering urinary function, surgery without organ preservation with urinary diversion may be an option.
A 2D detector array for relative dosimetry and beam steering for FLASH radiotherapy with electrons
Authors: Schönfeld Andreas A. , Hildreth Jeff , Bourgouin Alexandra , Flatten Veronika , Kozelka Jakub , Simon William , Schüller Andreas 
Published: December 2024

AbstractBackgroundFLASH radiotherapy is an emerging treatment modality using ultra‐high dose rate beams. Much effort has been made to develop suitable dosimeters for reference dosimetry, yet the spatial beam characteristics must also be characterized to enable computerized treatment planning, as well as quality control and service of a treatment delivery device. In conventional radiation therapy, this is commonly achieved by beam profile scans in a water phantom using a point detector. In ultra‐high dose rate beams, the delivered dose needed for a set of beam profile scans may exceed the regulatory dose limit specified for a typical treatment room, or degrade components of the scanning system and scanning detector. Point detector scans also cannot quantify the pulse‐to‐pulse stability of a beam profile. Detector arrays can overcome these challenges, but to date, no detector arrays suitable for ultra‐high dose rate beams are commercially available.PurposeThe study presents the development and characterization of a two‐dimensional detector array for measuring pulse‐resolved spatial fluence distributions in real‐time and temporal structure of intra‐pulse dose rate of ultra‐high pulsed dose rate (UHPDR) electron beams used in FLASH radiotherapy.MethodsThe performance of the SunPoint 1 diode was evaluated by measuring the response of the EDGE Detector in a 20 MeV UHPDR electron beam with a dose per pulse of 0.04 Gy – 6 Gy at a pulse duration of 1 µs or 1.9 µs, and instantaneous dose rates of 0.040 – 3.2 MGy·s−1. Based on the findings regarding a suitable signal acquisition technique, a PROFILER 2 detector array made of SunPoint 1 diodes was then modified by minimizing trace resistance, applying a reverse bias, and implementing an RC component to each diode to optimize the transfer of the collected charge during a pulse. The resultant “FLASH Profiler” was then tested in the same UHPDR electron beam.ResultsThe FLASH Profiler exhibited a linear response within ± 3% deviation over the investigated dose per pulse range. The FLASH Profiler array showed good agreement with the absolute dose measured using a flashDiamond point detector and an integrating current transformer for dose‐per‐pulse values of up to 6 Gy. The FLASH Profiler was able to measure lateral beam profiles in real‐time and on a single‐pulse basis. The ability to capture and display the profiles during steering of UHPDR beams was demonstrated. The SunPoint 1 diode was able to measure the pulse duration and the intra‐pulse dose rate with a time resolution of 4 ns.ConclusionThe FLASH Profiler could be used for characterizing UHPDR electron beams and facilitating quality control and beam steering service of electron FLASH irradiators.
Dependence of brain‐tissue R2 on MRI field strength
Authors: van Gelderen Peter , Wang Yicun , de Zwart Jacco A. , Duyn Jeff H. 
Published: December 2024

AbstractPurposeTo quantify T2 relaxation in the brain at 3 T and 7 T to study its field dependence and correlation with iron content, and to investigate whether iron can be separated from other sources of T2 relaxation based on this field dependence.MethodsNine subjects were scanned at both field strengths with the same acquisition technique, which used multiple gradient‐echo sampling of a spin echo. This allowed for separation of T2 relaxation from static dephasing by B0 field inhomogeneities and the effects of radiofrequency refocusing imperfections. The average relaxation rates (R2 = 1/T2) in multiple regions of interest in the brain were fitted with a model linear in B0 and correlated with literature iron values.ResultsThe relationship between the R2 values at the two field strengths appeared to be linear over all regions of interest. The R2 values (in s−1) in the regions of interest for which both an iron and a lipid mass fraction have been documented in the literature were fitted as , where and indicate the putative mass fractions of iron and lipid.ConclusionThe R2 relaxation rate is well described by a constant plus a term linear in B0, with both iron and lipid content contributing to the slope. This indicates that the contributions of lipid and iron to R2 cannot be separated based solely on the field dependence of R2 in the field range of 3–7 T.
Absorption‐coefficient calculation of short‐wavelength photoresist materials: From EUV to BEUV and water window X‐ray
Authors: Peng Yifeng , Chen Pengzhong , Chen Hao , Si YouMing , Peng Xiaojun 
Published: December 2024

AbstractIn photolithography, shortening the exposure wavelength from ultraviolet to extreme ultraviolet (EUV, 13.5 nm) and soft X‐ray region in terms of beyond EUV (BEUV, 6.X nm) and water window X‐ray (WWX, 2.2–4.4 nm) is expected to further miniaturize the technology node down to sub‐5 nm level. However, the absorption ability of molecules in these ranges, especially WWX region, is unknown, which should be very important for the utilization of energy. Herein, the molar absorption cross sections of different elements at 2.4 nm of WWX were firstly calculated and compared with the wavelengths of 13.5 nm and 6.7 nm. Based on the absorption cross sections in these ranges and density estimation results from the density‐functional theory calculation, the linear absorption coefficients of typical resist materials, including metal‐oxy clusters, organic small molecules, polymers, and photoacid generators (PAGs), are evaluated. The analysis suggests that the Zn cluster has higher absorption in BEUV, whereas the Sn cluster has higher absorption in WWX. Doping PAGs with high EUV absorption atoms improves chemically amplified photoresist (CAR) polymer absorption performance. However, for WWX, it is necessary to introduce an absorption layer containing high WWX absorption elements such as Zr, Sn, and Hf to increase the WWX absorption.