bluuebunny/crossref_metadata_2025_split huggingface dataset:
Osteoporosis Knowledge, Beliefs and Self-efficacy Among Female University Students: A Descriptive Study
Authors: Shawashi Tagreed O. , Darawad Muhammad 
Published: October 2020

Aim:
This study aimed to investigate female university students' knowledge, beliefs and self-efficacy regarding osteoporosis.

Methods:
This is a descriptive cross-sectional study conducted amongst 260 female university students in Jordan. This study utilized a package of instruments to measure different variables of the study, including demographic data, Osteoporosis Knowledge Assessment Tool (OKAT), Osteoporosis Health Belief Scale (OHBS) and Osteoporosis Self-Efficacy Scale (OSES).

Results:
Participants had a relatively low level of knowledge regarding osteoporosis (M=8.1/20, 40.5%). In general, they had fairly positive beliefs towered osteoporosis with a percentage of 70% (M=3.5/5, SD=0.3) and moderate self-efficacy in practicing osteoporosis recommended practices. No significant differences were observed in participants’ knowledge, beliefs, and self-efficacy of osteoporosis based on their demographic variables except their college specialty.

Conclusion:
The current study confirmed that female university students had inadequate knowledge about osteoporosis. There is a gap between the participants' beliefs, self-efficacy about osteoporosis and their daily lifestyle. In view of such lack of knowledge of osteoporosis, efforts should be made to raise the level of osteoporosis awareness among university students through health education intervention programs for all-female university students regardless of their college, specialty or academic program.
In-Silico Structure-Based Drug Discovery of Candidate Drugs against Novel Protein Receptor Complex Nsp10-Nsp16 of SARS-CoV-2 using Drug Repurposing Approach
Authors: Sengupta Abhishek , Vijayaraghavan Pooja , Srivastava Priyansh , Gupta Lovely , Chandwani Chaitanya , Narad Priyanka 
Published: October 2020

Background:
Several therapeutic possibilities have been explored against Severe Acute Respiratory
Syndrome-2 (SARS-CoV-2), such as convalescent plasma (CP), intravenous immunoglobulin
(IVIG) and monoclonal antibodies. Compounds such as hydroxychloroquine have also been found to
have fatal drawbacks. Repurposing of existing antiviral drugs can be an effective strategy, which could
fasten up the process of drug discovery.

Objective:
The present study is designed to predict the computational efficacy of pre-existing antiviral
drugs as inhibitors for the Nsp10-Nsp16 complex protein of SARS-CoV-2.

Methods:
Twenty-six known antiviral drugs along with their similar structures based on Tanimoto similarity,
were screened towards the Nsp10-Nsp16 complex’s active site.

Results:
Our study reports competitive binding of 1-[3-[2-(2-Ethoxyphenoxy) ethylamino]-2-
hydroxypropyl] -9H-carbazol-4-ol against AdoMet binding site in Nsp10-Nsp16 complex. Formation of
the stable ligand-receptor complex with 1-[3-[2-(2-Ethoxyphenoxy) ethylamino]-2-hydroxypropyl] -9Hcarbazol-
4-ol could functionally inhibit the Nsp10-Nsp16 complex, thereby making the SARS-CoV-2
vulnerable to host immuno-surveillance mechanisms.

Conclusion:
We conclude that these computational hits can display positive results in in-vitro trials
against SARS-CoV-2.
Fitness-Tracker Assisted Frailty-Assessment Before Transcatheter Aortic Valve Implantation: Proof-of-Concept Study
Authors: Mach Markus , Watzal Victoria , Hasan Waseem , Andreas Martin , Winkler Bernhard , Weiss Gabriel , Strouhal Andreas , Adlbrecht Christopher , Delle Karth Georg , Grabenwöger Martin 
Published: October 2020

Background
While transcatheter aortic valve replacement (TAVR) has revolutionized the treatment of aortic valve stenosis, wearable health-monitoring devices are gradually transforming digital patient care.

Objective
The aim of this study was to develop a simple, efficient, and economical method for preprocedural frailty assessment based on parameters measured by a wearable health-monitoring device.

Methods
In this prospective study, we analyzed data of 50 consecutive patients with mean (SD) age of 77.5 (5.1) years and a median (IQR) European system for cardiac operative risk evaluation (EuroSCORE) II of 3.3 (4.1) undergoing either transfemoral or transapical TAVR between 2017 and 2018. Every patient was fitted with a wrist-worn health-monitoring device (Garmin Vivosmart 3) for 1 week prior to the procedure. Twenty different parameters were measured, and threshold levels for the 3 most predictive categories (ie, step count, heart rate, and preprocedural stress) were calculated. Patients were assigned 1 point per category for exceeding the cut-off value and were then classified into 4 stages (no, borderline, moderate, and severe frailty). Furthermore, the FItness-tracker assisted Frailty-Assessment Score (FIFA score) was compared with the scores of the preprocedural gait speed category derived from the 6-minute walk test (GSC-6MWT) and the Edmonton Frail Scale classification (EFS-C). The primary study endpoint was hospital mortality.

Results
The overall preprocedural stress level (P=.02), minutes of high stress per day (P=.02), minutes of rest per day (P=.045), and daily heart rate maximum (P=.048) as single parameters were the strongest predictors of hospital mortality. When comparing the different frailty scores, the FIFA score demonstrated the greatest predictive power for hospital mortality (FIFA area under the curve [AUC] 0.844, CI 0.656-1.000; P=.048; GSC-6MWT AUC 0.671, CI 0.487-0.855; P=.42; EFS-C AUC 0.636, CI 0.254-1.000; P=.44).

Conclusions
This proof-of-concept study demonstrates the strong predictive performance of the FIFA score compared to that of the conventional frailty assessments.
Exploring How Older Adults Use a Smart Speaker–Based Voice Assistant in Their First Interactions: Qualitative Study
Authors: Kim Sunyoung 
Published: October 2020

Background
Smart speaker–based voice assistants promise support for the aging population, with the advantages of hands-free and eyes-free interaction modalities to handle requests. However, little is known about how older adults perceive the benefits of this type of device.

Objective
This study investigates how older adults experience and respond to a voice assistant when they first interact with it. Because first impressions act as strong predictors of the overall attitude and acceptability of new technologies, it is important to understand the user experiences of first exposure.

Methods
We conducted semistructured interviews with 18 people 74 years and older who had never used a smart speaker before, investigating the patterns of use, usability issues, and perspectives that older adults have when using a voice assistant for the first time.

Results
The overall first response to a voice assistant was positive, thanks to the simplicity of a speech-based interaction. In particular, a positive and polite response to complete the interaction with a voice assistant was prevalent, such as expressing gratitude or giving feedback about the quality of answers. Two predominant topics of commands made in the first interaction include asking health care–related questions and streaming music. However, most of the follow-up reactions were unfavorable because of the difficulty in constructing a structured sentence for a command; misperceptions about how a voice assistant operates; and concerns about privacy, security, and financial burdens. Overall, a speech-based interaction was perceived to be beneficial owing to its efficiency and convenience, but no other benefits were perceived.

Conclusions
On the basis of the findings, we discuss design implications that can positively influence older adults' first experiences with a voice assistant, including helping better understand how a voice assistant works, incorporating mistakes and common interaction patterns into its design, and providing features tailored to the needs of older adults.
Toward Preparing a Knowledge Base to Explore Potential Drugs and Biomedical Entities Related to COVID-19: Automated Computational Approach
Authors: Khan Junaed Younus , Khondaker Md Tawkat Islam , Hoque Iram Tazim , Al-Absi Hamada R H , Rahman Mohammad Saifur , Guler Reto , Alam Tanvir , Rahman M Sohel 
Published: October 2020

Background
Novel coronavirus disease 2019 (COVID-19) is taking a huge toll on public health. Along with the non-therapeutic preventive measurements, scientific efforts are currently focused, mainly, on the development of vaccines and pharmacological treatment with existing drugs. Summarizing evidences from scientific literatures on the discovery of treatment plan of COVID-19 under a platform would help the scientific community to explore the opportunities in a systematic fashion.

Objective
The aim of this study is to explore the potential drugs and biomedical entities related to coronavirus related diseases, including COVID-19, that are mentioned on scientific literature through an automated computational approach.

Methods
We mined the information from publicly available scientific literature and related public resources. Six topic-specific dictionaries, including human genes, human miRNAs, diseases, Protein Databank, drugs, and drug side effects, were integrated to mine all scientific evidence related to COVID-19. We employed an automated literature mining and labeling system through a novel approach to measure the effectiveness of drugs against diseases based on natural language processing, sentiment analysis, and deep learning. We also applied the concept of cosine similarity to confidently infer the associations between diseases and genes.

Results
Based on the literature mining, we identified 1805 diseases, 2454 drugs, 1910 genes that are related to coronavirus related diseases including COVID-19. Integrating the extracted information, we developed the first knowledgebase platform dedicated to COVID-19, which highlights potential list of drugs and related biomedical entities. For COVID-19, we highlighted multiple case studies on existing drugs along with a confidence score for their applicability in the treatment plan. Based on our computational method, we found Remdesivir, Statins, Dexamethasone, and Ivermectin could be considered as potential effective drugs to improve clinical status and lower mortality in patients hospitalized with COVID-19. We also found that Hydroxychloroquine could not be considered as an effective drug for COVID-19. The resulting knowledgebase is made available as an open source tool, named COVID-19Base.

Conclusions
Proper investigation of the mined biomedical entities along with the identified interactions among those would help the research community to discover possible ways for the therapeutic treatment of COVID-19.
HUBUNGAN METODE PENGASUHAN ORANG TUA PADA ANAK DENGAN PERKEMBANGAN KEPERCAYAAN DIRI (SELF CONFIDENCE) ANAK USIA 6-7 TAHUN DI ANAK AIR KELURAHAN BATIPUH PANJANG KOTA PADANG
Authors: Yovita Yesi 
Published: October 2020

ABSTRACT This research was motivated by the low self-confidence development of children aged 6-7 years in Anak Air, Batipuh Panjang Village, Padang City. It is suspected that the cause of the child's low self-confidence is partly due to the inappropriate application of parenting methods. This study aims to: 1) describe the parenting methods applied by parents to children; 2) describes the self-confidence of children aged 6-7 years; and 3) looking at the relationship between parenting methods and the self-confidence of children aged 6-7 years in Anak Air, Batipuh Panjang Village, Padang City.This research is a correlational quantitative research. The population in this study were children aged 6-7 years and their mothers as many as 50 people with a sample of 75%, namely 38 people with simple random sampling technique. The data technique used a questionnaire and a check for the observation of children's self-confidence development, the data obtained were analyzed using descriptive analysis and formula-data-moment.The results of this study indicate: 1) the parenting methods applied by parents to children aged 6-7 years are still inaccurate and inconsistent; 2) the development of self-confidence of children aged 6-7 years is still low; and 3) there is a significant relationship between parenting methods and the development of self-confidence of children aged 6-7 years in Anak Air, Batipuh Panjang Village, Padang City. Research suggestions are: 1) it is hoped that parents in Anak Air Kelurahan Batipuh Panjang Padang City can pay attention to and apply the application of parenting methods to children so that they can contribute to the development of children's self-confidence as expected; and 2) it is hoped that further researchers can find or examine other variables that affect the development of children's self-confidence. Keywords: self-confidence, parenting methods, family education
Zina dalam Perspektif Tafsir Al-Qur’an
Authors: Talebe Tamrin 
Published: October 2020

This article explores the interpretation of the verse about adultery in the QS. Al-Isra; 32, QS. Al-Nur; 2 in perspective of the Qur'anic Interpretation. The object of the Qur’anic interpretation in this study is the interpretation of al-Tahrir wa al-Tanwir by Ibn ‘Asyur, Tafsir al-Munir by Wahba al-Zuhaili. The study of the interpretation of the Qur'an has a perspective based on asbab al-nuzul, munasabah and the meaning contained in the verse. The results found in the interpretation of the Qur’an showed that the act of adultery is one of the strongly prohibited acts, the law taxt is a strict law and provides the connotation of disclosure loaded with very adverse effects on perpetrators, families and the wider community.
Keywords :adultery and Tafsir
Penafsiran Kontekstual Kesaksian Perempuan
Authors: Arifin Muhammad Patri 
Published: October 2020

The position of women in Islam still holds a problem that is an imbalance or bias between the position of men and women. One of the causes of the emergence of such imbalances is the religious teachings that place the woman in a disadvantaged position compared to the men’s position. Religious teachings can be represented by the content of the Qur'an and Hadith, while the understanding of religious teachings can be found from the sheets of books tafsir fikih and syarah hadith of the Prophet. Among the Qur'anic verses that some have considered to be discriminatory and gender biased are surah Al Baqarah verse 282 on the testimony of women in debt transaction. To contextualize this verse, the understanding of the historical situation, whether the macro situation (State of the Arabian peninsula) as well as micro situations (asbab an nuzul) which is a very appropriate step to eliminate such discriminatory stigma. At that time, the context of women did not have sufficient experience in financial m tters which at that time was dominated by men. So the problem is not on the gender whether male or female, but on credibility when it was given to be a witness.
LA EFECTIVIDAD DE LOS DERECHOS HUMANOS Y SUS GARANTÍAS
Authors: Burgoa Toledo Carlos 
Published: October 2020

Los derechos humanos son una novedad legislativa en México motivo de la reforma constitucional de junio en 2011, lo que ha propiciado una serie de cambios en las decisiones y actos de todas las autoridades estatales, pues tanto el legislador como las autoridades administrativas y jurisdiccional deben respetar y satisfacer los derechos individuales y sociales, ante lo cual surgen dos problemas: la interpretación debida de los derechos y la porción económica de los fondos destinados presupuestalmente para su satisfacción, todo lo cual conforma un reto de suma importancia para este nuevo etapa de la vida jurídica del país, cuyas aristas y complicaciones no se tienen del todo contempladas y por ende, producen eventualmente la efectividad e inefectividad de los derechos humanos y sus garantías.
UNIVERSOS JURÍDICOS, NÚMERO 13
Authors: JURÍDICOS UNIVERSOS 
Published: October 2020

Universos Jurídicos, año 7, No. 13, noviembre 2019-abril 2020, es una publicación semestral editada por la Universidad Veracruzana a través del Instituto de Investigaciones Jurídicas. Lomas del estadio S/N, col. Centro. C.P. 91000. Xalapa, Veracruz, México. Teléfono +52 (228)8186841. http://www.uv.mx/iij, fabaez@uv.mx. Reserva de Derechos al uso exclusivo No. 04-2013-041509530000-203, ISSN 2007-9125, Ambos otorgados por el Instituto Nacional del Derecho de Autor. Responsable de la última actualización de este número: Instituto de Investigaciones Jurídicas, calle Hermenegildo Galeana esquina 7 de noviembre S/N, Zona Centro, C.P. 91000. Fecha de la última modificación de este número: 30 de abril de 2020.Las opiniones expresadas por los autores no necesariamente reflejan la postura del editor de la publicación.Queda prohibida la reproducción total o parcial de los contenidos e imágenes de la publicación sin previa autorización de la Universidad Veracruzana.
Prevalence and molecular genetic features of epidermolysis bullosa in Krasnodar Krai
Authors: Pavlyuchenko I. I. , Gusaruk L. R. , Tekutskaya E. E. , Rubtsova I. T. 
Published: October 2020

Background. Epidermolysis bullosa defi nes a clinically and genetically heterogeneous group of severe orphan disorders manifested with a congenital propensity for bullae (blisters) propagation on skin and mucous membranes of oesophagus, intestine, respiratory and urogenital systems. In the Russian Federation, its incidence rate is 1 per 50 –300 thousand of people. The actual disease prevalence in Krasnodar Krai is undefi ned. The genetic basis of this hereditary pathology has been studied insuffi ciently.Objectives. Epidemiological description of epidermolysis bullosa in Krasnodar Krai and detection of its chemical DNA signatures.Мethods. The prevalence of epidermolysis bullosa in Krasnodar Krai was studied with a relevant patient sample selected in an electronic archive of primary physician visits during 2010–2018. Chemical DNA signatures were detected as levels of blood serum 8-oxoguanine, a common marker of oxidative lesion. The 8-oxoguanine concentration was determined in ELISA assays with monoclonal antibodies. Statistical signifi cance was estimated with the chi-square and Mann–Whitney U test criteria for small samples.Results. A retrospective study revealed the total incidence rate of epidermolysis bullosa in Krasnodar Krai as 0.96 per 100,000 population, with prevalence in people aged under 30 years (75.5% of all patients, p < 0.01). In Krasnodar Krai, epidermolysis bullosa simplex accounts for 54.7% of total observed cases. Lethal form was diagnosed in 13.2%, and dystrophic type — in 5.7%. Diagnosis was incomplete as per type in 26.4% of patients. Serum 8-oxoguanine concentration in pathology comprised 14.8 ± 1.9 ng/mL, which exceeds 1.9-fold the control values of 7.7 ± 1.3 ng/mL (p < 0.01).Conclusion. The epidemiological profi le of epidermolysis bullosa in Krasnodar Krai was described. The disease prevalence, areal occurrence, predominant types and high-risk population groups were determined. A quarter of all patients had incomplete diagnosis as per the disease type. Elevated levels of 8-oxoguanine, the main product of DNA oxidation, indicate both genomic lesion and oxidative stress associated with epidermolysis bullosa.
Biopsychosocial variations in quality of life outcome following microdiscectomy
Authors: Houlihan Lena Mary , Meeke James , Dunlea Orla , O’Sullivan Michael G. J. , Lim Chris , Kaar George 
Published: October 2020

Background:
Lumbar microdiscectomy is one of the most frequently performed neurosurgical procedures. In this review, we ask why patients’ outcomes vary so widely even within the same unit, with the same surgeon performing the procedure and utilizing the technique?

Methods:
In a cohort of 87 patients, we investigated how/whether multiple patient variables impacted outcomes following single-level lumbar microdiscectomy. We studied whether early surgical intervention improved the patients’ quality of life (QOL) versus late intervention. Furthermore, we assessed other variables that could influence patient-perceived improvement. Preoperatively and postoperatively, we additionally utilized the following internationally standardized questionnaires (EQ-5D, Oswestry, and Core Outcome Measures Index [COMI]).

Results:
A generalized substantial improvement in QOL was identified throughout the cohort population (<0.05). There was no difference in health measurement scores for those undergoing early versus late surgery. However, there was a statistically significant improvement in all QOL scores for privately insured patients versus publicly insured patients (e.g., on COMI, EQ-5D, and ODI Scores).

Conclusion:
There was no objective statistically significant difference in QOL health scores between patients undergoing early versus late surgical lumbar microdiscectomy. This would suggest that the length of time patients is symptomatic before surgery did not significantly impact postoperative outcome. Of interest, however, was the difference in QOL health scores for private versus public patients suggesting that there are more subjective, complex, and psychosocial issues that influence outcome.
Exploring the Future of the Teaching Materials Center at Illinois State University: From e-Textbooks to Makerspaces
Authors: Shelley Anne , Derden Julia M. , Gibson Sally 
Published: October 2020

In this project, co-investigators explored how college and university curriculum centers are addressing challenges with K-12 electronic textbooks (particularly acquisition, cataloging, and access) and implementing technology-focused services for pre-service teachers. The results of this research have provided guidance for planning the future of the curriculum center in Milner Library at Illinois State University, which comprises 2.5% of the library’s holdings and accounts for almost 25% of the library’s circulation. We identified service gaps and opportunities for improvement and are in the process of acting upon our findings, such as leveraging campus partnerships, integrating makerspace technologies, and exploring different models for ordering and processing the collection
AN ANALYSIS OF THE CONTENT WORDS USED IN A SCHOOL TEXTBOOK, TEAM UP ENGLISH 3, USED FOR GRADE 9 STUDENTS
Authors: Pijarnsarid Sukontip , Kongkaew Prommintra 
Published: October 2020

The purpose of this study were to study the content words used in a school textbook, Team Up in English 3, used for Grade 9 students and to study the frequency of content words used in a school textbook, Team Up in English 3, used for Grade 9 students. The study found that nouns is used with the highest frequency (79), followed by verb (58), adjective (46), and adverb (24).With the nouns analyzed, it was found that the Modifiers + N used with the highest frequency (92.40%), the compound nouns were ranked in second (7.59 %). Considering the verbs used in the text, it was found that transitive verbs were most commonly used (77.58%), followed by intransitive verbs (12.06%), linking verbs (10.34%). As regards the adjectives used in the text, there were 46 adjectives in total, 30 adjectives were used as attributive (65.21 %) and 16 adjectives were used as predicative (34.78%). As for the adverbs, it was found that adverbs of times were used with the highest frequency (37.5 % ), followed by the adverbs of purpose and degree (33.33%) , the adverbs of frequency (12.5 %) , the adverbs of place ( 8.33% ) and the adverbs of manner ( 8.33 % ).