bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Structured Review to Assess the Current Status of Cost-Based Burns Research in Nepal
Authors: Lowin Julia L , Poudel Ak Narayan , Price Patricia E , Potokar Tom S 
Published: August 2020

Abstract
The management of burns is costly and complex. The problem is compounded in low and middle income countries (LMICs) where the incidence of burn injuries is high but infrastructure and funding for management and prevention is limited. Cost of illness studies allows for quantification of the costs associated with public health problems. Without cost quantification, focus and allocation of funding is challenging. The authors explored the availability of cost-focused burns research data in a target LMIC. The focus of their research was Nepal. A structured literature review including published papers, Ministry of Health (MOH) and World Health Organization (WHO) statistics was conducted to identify cost of illness studies or evidence relating to burn-related resource and costs. Gaps in the evidence base were highlighted. Research methodologies from other LMICs were reviewed. We found 32 papers related to burn injury in Nepal, one key MOH document and one relevant WHO data source. Most research focused on the epidemiology and etiology of burns in Nepal. Of the papers, only 14 reported any type of burn-related resource use and only 1 paper directly reported (limited) cost data. No studies attempted an overall quantification of the cost of burns. MOH statistics provided no additional insight into costs. Our study found an almost complete lack of cost-focused burns research in Nepal. Primary research is needed to quantify the cost of burns in Nepal. Initial focus could usefully be on the cost of care in tertiary hospitals. A full cost of burns for Nepal remains some way off.
A new pinnotherid crab of the genusPinnixulalaPalacios Theil, Cuesta & Felder, 2016 from uncertain infaunal hosts in the northern Gulf of Mexico, with a rediagnosis and updated synonymy for the polychaete symbiontPinnixulala retinens(Rathbun, 1918) (Decapoda: Brachyura: Pinnotheridae)
Authors: Felder Darryl L , Palacios Theil Emma 
Published: August 2020

AbstractA new infaunal pinnotherid crab, Pinnixulala heardin. sp., is described from muddy substrates of the middle to inner continental shelf of the northern Gulf of Mexico. Molecular genetic analysis supports its separation from P. retinens (Rathbun, 1918), the only other western Atlantic member of the genus and a species most commonly found living as a symbiont of large polychaete worms. Both western Atlantic species are clearly separated from several described and undescribed populations of congeners occurring along shorelines of the eastern Pacific. We herein include a rediagnosis of P. retinens to facilitate morphological comparisons with P. heardin. sp. Unlike P. retinens, which is more common in shallow inshore waters and reaches larger sizes, the new species lacks development of a strong distally directed spine on the fourth pereopod ischium and has chelae that are at least as heavily developed as the second and third pereopods. In addition, the mature male first gonopods in P. heardin. sp. are tapered over their terminal one-third and directed distally, rather than being curved in their terminal one-third with the tips directed mesially, as they are in P. retinens. The new species is invariably collected from samples including infaunal worms and other invertebrates, but the specific hosts remain to be determined
The current state of immunotherapy for primary and secondary brain tumors: similarities and differences
Authors: Nejo Takahide , Mende Abigail , Okada Hideho 
Published: August 2020

Abstract
Treatment and resolution of primary and metastatic brain tumors have long presented a challenge to oncologists. In response to the dismal survival outcomes associated with conventional therapies, various immunotherapy modalities, such as checkpoint inhibitors, vaccine, cellular immunotherapy and viral immunotherapy have been actively explored over the past couple of decades. Although improved patient survival has been more frequently noted in treatment of brain metastases, little progress has been made in improving patient survival in cases of primary brain tumors, specifically glioblastoma, which is the representative primary brain tumor discussed in this review. Herein, we will first overview the findings of recent clinical studies for treatment of primary and metastatic brain tumors with immunotherapeutic interventions. The clinical efficacy of these immunotherapies will be discussed in the context of their ability or inability to overcome inherent characteristics of the tumor as well as restricted antigen presentation and its immunosuppressive microenvironment. Additionally, this review aims to briefly inform clinicians in the field of neuro-oncology on the relevant aspects of the immune system as it pertains to the central nervous system, with special focus on the differing modes of antigen presentation and tumor microenvironment of primary and metastatic brain tumors and the role these differences may play in the efficacy of immunotherapy in eradicating the tumor.
Opioid Use Disorder and Overdose in Older Adults With Breast, Colorectal, or Prostate Cancer
Authors: Roberts Andrew W , Eiffert Samantha , Wulff-Burchfield Elizabeth M , Dusetzina Stacie B , Check Devon K 
Published: August 2020

Abstract

Background
Despite high rates of opioid therapy, evidence about the risk of preventable opioid harms among cancer survivors is underdeveloped. Our objective was to estimate the odds of opioid use disorder (OUD) and overdose following breast, colorectal, or prostate cancer diagnosis among Medicare beneficiaries.

Methods
We conducted a retrospective cohort study using 2007-2014 Surveillance, Epidemiology, and End Results-Medicare data for cancer survivors with a first cancer diagnosis of stage 0-III breast, colorectal, or prostate cancer at age 66-89 years between 2008 and 2013. Cancer survivors were matched to up to 2 noncancer controls on age, sex, and Surveillance, Epidemiology, and End Results region. Using Firth logistic regression, we estimated adjusted 1-year odds of OUD or nonfatal opioid overdose associated with a cancer diagnosis. We also estimated adjusted odds of OUD and overdose separately and by cancer stage, prior opioid use, and follow-up time.

Results
Among 69 889 cancer survivors and 125 007 controls, the unadjusted rates of OUD or nonfatal overdose were 25.2, 27.1, 38.9, and 12.4 events per 10 000 patients in the noncancer, breast, colorectal, and prostate samples, respectively. There was no association between cancer and OUD. Colorectal survivors had 2.3 times higher odds of opioid overdose compared with matched controls (adjusted odds ratio = 2.33, 95% confidence interval  = 1.49 to 3.67). Additionally, overdose risk was greater in those with more advanced disease, no prior opioid use, and preexisting mental health conditions.

Conclusions
Opioid overdose was a rare, but statistically significant, outcome following stage II-III colorectal cancer diagnosis, particularly among previously opioid-naïve patients. These patients may require heightened screening and intervention to prevent inadvertent adverse opioid harms.
Haemophilus haemolyticus: an atypical pathogen of septic arthritis of the knee joint
Authors: Weber Sabrina , Kabelitz Method , Kabelitz Nina , Schoenborn Veit 
Published: August 2020

Abstract
Septic knee arthritis is a common disease, mostly due to bacterial infections. We describe a rare case of Haemophilus haemolyticus causing unilateral septic arthritis of a native knee. The affected patient presented with persistent severe knee pain after repeated intra-articular injections. Patient history included knee arthroscopy and a known rheumatoid arthritis treated by steroids. Since conservative treatment was ineffective and infection could not be excluded, diagnostic arthroscopy was performed. Synovial fluid and biopsies verified the uncommon microorganism and antibiotic therapy was initiated. Clinical findings and blood results showed rapid improvement. The patient was discharged in a good condition after 6 weeks. A review of the current literature describes only one joint infection with H. haemolyticus as underlying cause. In immunocompromised patients with septic knee arthritis also atypical pathogens must be considered. Nevertheless, the established treatment algorithm with arthroscopy and anti-infective therapy seems to be effective leading to satisfactory results.
What does it take to be antiviral? An Argonaute-centered perspective on plant antiviral defense
Authors: Silva-Martins Guilherme , Bolaji Ayooluwa , Moffett Peter 
Published: August 2020

AbstractRNA silencing is a major mechanism of constitutive antiviral defense in plants, mediated by a number of proteins, including the Dicer-like (DCL) and Argonaute (AGO) endoribonucleases. Both DCL and AGO protein families comprise multiple members. In particular, the AGO protein family has expanded considerably in different plant lineages, with different family members having specialized functions. Although the general mode of action of AGO proteins is well established, the properties that make different AGO proteins more or less efficient at targeting viruses are less well understood. In this report, we review methodologies used to study AGO antiviral activity and current knowledge about which AGO family members are involved in antiviral defense. In addition, we discuss what is known about the different properties of AGO proteins thought to be associated with this function.
Effect of Addition of WZB117 as an Inhibitor of Glucose Transporter 1 for Venous Blood Glucose Determination
Authors: Zhang Lei , Ran Yaqiong , Zhu Yan , Zhen Qianna 
Published: August 2020

Abstract

Objective
Sodium fluoride (NaF) has been applied to inhibit glycolysis in venous specimens for decades. However, it has had little effect on the rate of glycolysis in the first 1 to 2 hours, resulting in a decrease of glucose, so a more efficient method is needed. Recently, we discovered that WZB117, a specific Glut1 inhibitor, restricts glycolysis by inhibiting the passive sugar transport of human red blood cells and cancer cells. The purpose of this study was to evaluate the results of intravenous blood glucose determination after the addition of WZB117.

Methods
Venous specimens from 40 pairs of healthy volunteers were collected for several days and placed in tubes containing NaF plus EDTA-disodium (Na2) without WZB117 (the A group); citric acid, trisodium citrate, and EDTA-Na2 without WZB117 (B group); and NaF plus EDTA-Na2 with WZB117 (C group). The glucose concentration was measured after venipuncture and compared with test tubes treated for 1 hour, 2 hours, and 3 hours before centrifugation. Glucose level was determined by the hexokinase method. The paired t-test was used to examine differences in glucose values at baseline and at different time points. The number of misdiagnoses and the misdiagnosis rate were calculated at 2 diagnostic stages: high risk of diabetes (glucose level of 6.1 mmol/L) and diagnosis of diabetes (glucose level of 7.0 mmol/L).

Results
Glucose levels decreased by 1.0% at 1 hour and by 2.1% at 3 hours in the C group tubes and simultaneously decreased by 1.7% at 1 hour and by 2.5% at 3 hours in the B group tubes. In contrast, glucose levels decreased by 4.1% at 1 hour and by 6.3% at 3 hours in the A group tubes. There was a statistically significant difference in glucose levels measured in the A group tubes and B group tubes at 1 hour, 2 hours, and 3 hours. The misdiagnosis rate of clinical diagnosis in diabetes was highest in the A group tubes (7.0‰ at 1 hour, 0.1‰ at 3 hours at 7.0 mmol/L point; 14.6‰ at 1 hour, 0.4‰ at 3 hours at 6.1 mmol/L point) and lowest in the C group tubes (2.95‰ at 1 hour, 0‰ at 3 hours at 7.0 mmol/L point; 4.8‰ at 1 hour, 0.1‰ at 3 hours at 6.1 mmol/L point).

Conclusion
The tube addition of WZB117 is more suitable for minimizing glycolysis and has no effect on glucose levels even if specimens are left uncentrifuged for up to 3 hours.
Multiwavelength modelling of the circumstellar environment of the massive protostar AFGL 2591 VLA 3
Authors: Olguin F A , Hoare M G , Johnston K G , Motte F , Chen H-R V , Beuther H , Mottram J C , Ahmadi A , Gieser C , Semenov D , Peters T , Palau A , Klaassen P D , Kuiper R , Sánchez-Monge Á , Henning Th 
Published: August 2020

ABSTRACT
We have studied the dust density, temperature, and velocity distributions of the archetypal massive young stellar object (MYSO) AFGL 2591. Given its high luminosity ($L=2\times 10^5\, \mbox{L$_{\odot}$}$) and distance (d = 3.3 kpc), AFGL 2591 has one of the highest $\sqrt{L}/d$ ratio, giving better resolved dust emission than any other MYSO. As such, this paper provides a template on how to use resolved multiwavelength data and radiative transfer to obtain a well-constrained 2D axisymmetric analytic rotating infall model. We show for the first time that the resolved dust continuum emission from Herschel 70- μm observations is extended along the outflow direction, whose origin is explained in part from warm dust in the outflow cavity walls. However, the model can only explain the kinematic features from CH3CN observations with unrealistically low stellar masses (&lt;15 M⊙), indicating that additional physical processes may be playing a role in slowing down the envelope rotation. As part of our three-step continuum and line fitting, we have identified model parameters that can be further constrained by specific observations. High-resolution mm visibilities were fitted to obtain the disc mass (6 M⊙) and radius (2200 au). A combination of SED and near-infrared observations were used to estimate the luminosity and envelope mass together with the outflow cavity inclination and opening angles.
Ly α blobs from cold streams undergoing Kelvin–Helmholtz instabilities
Authors: Mandelker Nir , van den Bosch Frank C , Nagai Daisuke , Dekel Avishai , Birnboim Yuval , Aung Han 
Published: August 2020

ABSTRACT
We present an analytic toy model for the radiation produced by the interaction between cold streams thought to feed massive haloes at high redshift and their hot CGM. We begin by deriving cosmologically motivated parameters for the streams, as they enter the halo virial radius, Rv, as a function of halo mass and redshift. For $10^{12}\, {\rm M}_\odot$ haloes at z = 2, we find the stream density to be $n_{\rm H,s}\sim (0.1{\!-\!}5)\times 10^{-2}\, {\rm cm}^{-3}$, a factor of δ ∼ (30–300) times denser than the hot CGM, while stream radii are in the range Rs ∼ (0.03−0.50)Rv. As streams accelerate towards the halo centre, they become denser and narrower. The stream–CGM interaction induces Kelvin–Helmholtz instability (KHI), which leads to entrainment of CGM mass by the stream and to stream deceleration by momentum conservation. Assuming the entrainment rates derived by Mandelker et al. (2020) in the absence of gravity can be applied locally at each halocentric radius, we derive equations of motion for the stream in the halo. Using these, we derive the net acceleration, mass growth, and energy dissipation induced by the stream–CGM interaction, as a function of halo mass and redshift, for different CGM density profiles. For the range of model parameters considered, we find that the interaction induces dissipation luminosities Ldiss &gt; 1042 erg s−1 within ≲0.6Rv of haloes with $M_{\rm v}\gt 10^{12}\, {\rm M}_\odot$ at z = 2. The emission scales with halo mass and redshift approximately as $\propto M_{\rm v}\, (1+z)^2$. The magnitude and spatial extent of the emission are consistent with observed Ly α blobs, though better treatment of the UV background and self-shielding is needed to solidify this conclusion.
Probing the atmosphere of HD189733b with the Na i and K i lines
Authors: Keles E , Kitzmann D , Mallonn M , Alexoudi X , Fossati L , Pino L , Seidel J V , Carroll T A , Steffen M , Ilyin I , Poppenhäger K , Strassmeier K G , von Essen C , Nascimbeni V , Turner J D 
Published: August 2020

ABSTRACT
High spectral resolution transmission spectroscopy is a powerful tool to characterize exoplanet atmospheres. Especially for hot Jupiters, this technique is highly relevant, due to their high-altitude absorption, e.g. from resonant sodium (Na i) and potassium (K i) lines. We resolve the atmospheric K i absorption on HD189733b with the aim to compare the resolved K i line and previously obtained high-resolution Na i-D line observations with synthetic transmission spectra. The line profiles suggest atmospheric processes leading to a line broadening of the order of ∼10 km/s for the Na i-D lines and only a few km/s for the K i line. The investigation hints that either the atmosphere of HD189733b lacks a significant amount of K i or the alkali lines probe different atmospheric regions with different temperature, which could explain the differences we see in the resolved absorption lines.
A search for transiting planets around FGKM dwarfs and subgiants in the TESS full frame images of the Southern ecliptic hemisphere
Authors: Montalto M , Borsato L , Granata V , Lacedelli G , Malavolta L , Manthopoulou E E , Nardiello D , Nascimbeni V , Piotto G 
Published: August 2020

ABSTRACT
In this work, we present the analysis of 976 814 FGKM dwarf and subgiant stars in the Transiting Exoplanet Survey Telescope (TESS) full frame images (FFIs) of the Southern ecliptic hemisphere. We present a new pipeline, DIAmante, developed to extract optimized, multisector photometry from TESS FFIs and a classifier, based on the Random Forest technique, trained to discriminate plausible transiting planetary candidates from common false positives. A new statistical model was developed to provide the probability of correct identification of the source of variability. We restricted the planet search to the stars located in the least crowded regions of the sky and identified 396 transiting planetary candidates among which 252 are new detections. The candidates’ radius distribution ranges between 1 R⊕ and 2.6 RJ with median value of 1 RJ and the period distribution ranges between 0.25 and 105 d with median value of 3.8 d. The sample contains four long period candidates (P &gt; 50 d), one of which is new, and 64 candidates with periods between 10 and 50 d (42 new ones). In the small planet radius domain (4R &lt; R⊕), we found 39 candidates among which 15 are new detections. Additionally, we present 15 single transit events (14 new ones), a new candidate multiplanetary system, and a novel candidate around a known TOI. By using Gaia dynamical constraints, we found that 70 objects show evidence of binarity. We release a catalogue of the objects we analysed and the corresponding light curves and diagnostic figures through the MAST and ExoFOP portals.
Quantifying excess power from radio frequency interference in Epoch of Reionization measurements
Authors: Wilensky Michael J , Barry Nichole , Morales Miguel F , Hazelton Bryna J , Byrne Ruby 
Published: August 2020

ABSTRACT
We quantify the effect of radio frequency interference (RFI) on measurements of the 21-cm power spectrum during the Epoch of Reionization (EoR). Specifically, we investigate how the frequency structure of RFI source emission generates contamination in higher order wave modes, which is much more problematic than smooth-spectrum foreground sources. Using a relatively optimistic EoR model, we find that even a single relatively dim RFI source can overwhelm the EoR power spectrum signal of $\sim 10\, {\rm mK}^2$ for modes $0.1 \ \lt k \lt 2 \, h\, {\rm Mpc}^{-1}$. If the total apparent RFI flux density in the final power spectrum integration is kept below 1 mJy, an EoR signal resembling this optimistic model should be detectable for modes $k \lt 0.9\, h\, {\rm Mpc}^{-1}$, given no other systematic contaminants and an error tolerance as high as 10 per cent. More pessimistic models will be more restrictive. These results emphasize the need for highly effective RFI mitigation strategies for telescopes used to search for the EoR.
Physicochemical models: source-tailored or generic?
Authors: Kulterer Beatrice M , Drozdovskaya Maria N , Coutens Audrey , Manigand Sébastien , Stéphan Gwendoline 
Published: August 2020

ABSTRACT
Physicochemical models can be powerful tools to trace the chemical evolution of a protostellar system and allow to constrain its physical conditions at formation. The aim of this work is to assess whether source-tailored modelling is needed to explain the observed molecular abundances around young, low-mass protostars or if, and to what extent, generic models can improve our understanding of the chemistry in the earliest stages of star formation. The physical conditions and the abundances of simple, most abundant molecules based on three models are compared. After establishing the discrepancies between the calculated chemical output, the calculations are redone with the same chemical model for all three sets of physical input parameters. With the differences arising from the chemical models eliminated, the output is compared based on the influence of the physical model. Results suggest that the impact of the chemical model is small compared to the influence of the physical conditions, with considered time-scales having the most drastic effect. Source-tailored models may be simpler by design; however, likely do not sufficiently constrain the physical and chemical parameters within the global picture of star-forming regions. Generic models with more comprehensive physics may not provide the optimal match to observations of a particular protostellar system, but allow a source to be studied in perspective of other star-forming regions.
The nearby extreme accretion and feedback system PDS 456: finding a complex radio-emitting nucleus
Authors: Yang Jun , Paragi Zsolt , Nardini Emanuele , Baan Willem A , Fan Lulu , Mohan Prashanth , Varenius Eskil , An Tao 
Published: August 2020

ABSTRACT
When a black hole accretes close to the Eddington limit, the astrophysical jet is often accompanied by radiatively driven, wide-aperture and mildly relativistic winds. Powerful winds can produce significant non-thermal radio emission via shocks. Among the nearby critical accretion quasars, PDS 456 has a very massive black hole (about 1 billion solar masses), shows a significant star-forming activity (about 70 solar masses per year), and hosts exceptionally energetic X-ray winds (power up to 20 per cent of the Eddington luminosity). To probe the radio activity in this extreme accretion and feedback system, we performed very long baseline interferometric (VLBI) observations of PDS 456 at 1.66 GHz with the European VLBI Network and the enhanced Multi-Element Remotely Linked Interferometry Network. We find a rarely seen complex radio-emitting nucleus consisting of a collimated jet and an extended non-thermal radio emission region. The diffuse emission region has a size of about 360 pc and a radio luminosity about three times higher than that of the nearby extreme starburst galaxy Arp 220. The powerful nuclear radio activity could result either from a relic jet with a peculiar geometry (nearly along the line of sight) or more likely from diffuse shocks formed naturally by the existing high-speed winds impacting on high-density star-forming regions.