bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advanced technologies in the modern era for augmented patient health care and drug delivery
Authors: Dev Asish , Khanra Soma , Shah Nilay 
Published: January 2020

The objective of the work is to recognize the recent advancements in the modern health care and drug delivery systems. The article describes few recent developments in technology like artificial intelligence, personalized medicines, customized medicines, 3D printing, bioelectronic devices and tele pharmacy, which have the potential to augment health care and drug delivery in coming times. Personalized medication ensures precise health care as per the individual genetic makeup of the patients. The 3D printing technology enables to deliver tailor made solutions to fulfil individual patient requirements. Bioelectronic medicines and devices are new technology where the patient wears a device and its electrical signal cures certain ailments. Tele pharmacy ensures that the technological advances of telecommunications are also passed on to the patient health care sector. Moreover, it can be said that all these modern developments ensure that the quality of life improves and there comes a better control on the health care costs.
Keywords: artificial intelligence, personalized medicines, customized medicines, 3D printing, bioelectronic devices and tele pharmacy
Parámetros meteorológicos, represamiento fluvial y huracanes. Variaciones en la hidrología del golfo de Batabanó, Cuba
Authors: Betanzos-Vega Abel , Capetillo-Piñar Norberto , Lopeztegui-Castillo Alexander , Garcés-Rodríguez Yuliesky , Tripp-Quezada Arturo 
Published: January 2020

El golfo de Batabanó (GB), es la región de la plataforma marina cubana de mayor extensión e importancia pesquera. Afectaciones al hábitat de especies marinas han sido señaladas como consecuencia de factores naturales y antrópicos. El objetivo fue determinar variaciones espacio-temporales significativas en la hidrología del GB en diferentes periodos y situaciones ambientales. Para ello se analizó la variabilidad de la lluvia y la temperatura del aire en 1975-1995 y 1996-2015 periodos de baja y alta actividad ciclónica, las características termohalinas del GB anterior (1959-1970) y posterior (2006-2016) al represamiento fluvial, y el efecto de dos huracanes casi simultaneaos en 2008 (“Gustav” e “Ike”). Diferencias significativas en la variabilidad interanual de parámetros meteorológicos entre el norte y el sur del GB respondieron a características locales, y ocurrieron cambios en la distribución de los meses de máximas precipitaciones. El represamiento fluvial, sumado a déficits de precipitación en primavera, verano e invierno, provocaron aumentos termohalinos en 2006-2016, con incremento de 0,7 °C en la temperatura del agua y de 2,3 en la salinidad promedio del GB, respecto a 1959-1970. La salinidad mostró una ampliación en la distribución de valores hipersalinos, y media > 36 en meses de altas precipitaciones, con promedio general de 35,4 en 1959-1970 y 37,7 en 2006-2016, esto sugiere que el represamiento ha sido un factor principal en las variaciones de salinidad. El impacto termohalino en el GB de dos huracanes en 2008, se restableció en corto plazo, con mayor inercia en la turbidez.
PENGARUH PENAMBAHAN EKSTRAK ETANOL SABUT KELAPA MUDA (Cocos nucifera Linn) DALAM SARI JAGUNG MANIS (Zea mays var. saccharata) TERHADAP BAKTERI Staphylococus aureus DAN Shigella dysenteriae
Authors: Fitriah Askhiatul , Khairuddin Khairuddin , Puspitasari Dwi Juli 
Published: January 2020

Telah dilakukan penelitian tentang pengaruh penambahan ekstrak etanol sabut kelapa muda (cocos nucifera Linn) dalam sari jagung manis (Zea mays var. saccharata) terhadap Staphylococcus aureus (gram positif) dan Shigella dysenteriae (gram negatif). Tujuan penelitian yaitu untuk mengetahui pengaruh penambahan konsentrasi ekstrak etanol sabut kelapa muda terhadap pertumbuhan koloni bakteri pada sari jagung manis, serta total pertumbuhan koloni bakteri terendah pada ekstrak etanol sabut kelapa muda dalam sari jagung manis. Metode maserasi digunakan dalam proses ekstraksi sabut kelapa muda dengan pelarut etanol, selanjutnya ekstrak sabut kelapa muda dicampurkan dengan sari jagung manis sesuai variasi konsentrasi 1%, 2%, 3%, 4% dan 5%. Analisis total pertumbuhan bakteri ekstrak etanol sabut kelapa muda dalam sari jagung manis dilakukan dengan metode TPC. Hasil penelitian menunjukkan bahwa total pertumbuhan koloni bakteri terendah yaitu pada konsentrasi 5% untuk bakteri Shigella dysenteriae sebesar 1,0x107 CFU/mL dan Staphylococus aureus sebesar 1,6x107CFU/mL.Kata kunci: Zea mays var. saccharata, Cocos nucifera Linn, antibakteri, total koloni
FORMULASI PAKAN UNGGUL BERBASIS BIOTEKNOLOGI LIMBAH ORGANIK LOKAL UNTUK IKAN LELE ORGANIK KUALITAS EKSPOR
Authors: Hala Yusafir , Kasim Syahruddin udin , Raya Indah 
Published: January 2020

Research on Superior Feed Formulations Based on Local Organic waste Biotechnology for Export quality organic Catfish. Research Objective: The discovery of feed types of tilapia and organic catfish that have export quality nutritional content based on the best quality local marine organic waste through a touch of biotechnology. Furthermore, the complete chemical composition of the waste used and feed components is obtained. Research Methods: Determine the best composition of biomass of marine organic waste and local onshore organic wastes with the highest levels of protein and carbohydrates and integrated with other wastes. The nutritional content is analyzed, namely: Carbohydrates, fats, proteins, and supporting minerals, namely: Fe, K and Ca. Instrumentation used to support the research objectives is AAS and HPLC. Research Results: Export quality organic catfish pellet feed in the form of waste: marine fish, sea shrimp waste, sea crab waste, rice bran waste, corn waste, mixed organic waste, golden snail waste, seaweed waste and coconut water waste respectively (27; 15; 7.5; 33; 3; 2.5; 5; 2.5 and 2) %b/ b, starch 2% b/b and marine phytoplankton biomass 0.5% b/b. The nutritional content of organic catfish pellets that have been produced, namely: 51% protein b/b, 24% carbohydrate b/b, 9% fat b/b, crude fiber 8%b/b, water content 2 - 2.5%b/b, mineral Fe 1% b/b, mineral K 1% b/b, mineral Ca 1%b/b, ash content 2 - 2.5%b/b. Feed packing for export quality organic catfish pellets is given the "SANTARI-KU" label.
Keywords: Superior feed, local organic waste biotechnology, export quality organic catfish, Santari-ku.
ANALISIS KADAR SERAT DAN KADAR PROTEIN SERTA PENGARUH WAKTU SIMPAN TERHADAP SEREAL BERBASIS TEPUNG AMPAS KELAPA DAN TEPUNG TEMPE
Authors: Mozin Fitrianingsih , Nurhaeni  , Ridhay Ahmad 
Published: January 2020

Research on dissolved protein and crude fiber flour based on coconut pulp and tempe flour has been performed. This study aims to determine the effect of shelf time on levels of dissolved protein and crude fiber flour-based cereal coconut pulp and tempeh flour. Cereals were made from coconut pulp flour and tempe flour as the main ingredients and the ratio of the ingredients was varied to 25:75; 50:50; and 75:25. The ratio of 25:75 produced the highest dissolved protein level of 3.88% and the 75:25 ratio produced the highest crude fiber of 21.96%.
Keywords: Coconut pulp flour, tempe flour, dissolved protein, crude fiber
KAJIAN AKTIVITAS ANTIOKSIDAN MIKROKAPSUL EKSTRAK KULIT TERONG UNGU (Solanum melongena L)
Authors: Lestari Efin , Sumarni Ni Ketut , Mappiratu Mappiratu 
Published: January 2020

Study about antioxidant activity of microcapsule of purple eggplant (Solanum melongena L) peel extract has ben done. The research aimed to find the best pH and coating ratio for yielding microcapsule with the highest antioxidant activity. It was done by applying 5 levels of both pH variation of 2, 3, 4, 5, 6 and maltodextrin ratio of 1:1, 2:1, 3:1, 4:1, 5:1 (w/v). The determination of antioxidant activity was done by DPPH method. The result showed that at pH 2 and 1:1 of maltodextrin coating ratio were the best condition to yield the highest antioxidant activity i.e 32.54 % and 96.31 %, respectively.
Keywords: Purple eggplant peel, maltodextrin, microcapsule, antioxidant activity
Long-term stability of miniscrew anchored maxillary molar distalization in Class II treatment
Authors: Bechtold Till Edward , Park Young-Chel , Kim Kyung-Ho , Jung Heekyu , Kang Ju-Young , Choi Yoon Jeong 
Published: January 2020

ABSTRACT

Objective
To investigate treatment stability of miniscrew-anchored maxillary distalization in Class II malocclusion.

Materials and Methods
This retrospective study included a distalization (n = 19) and a control (n = 19) group; a patient group with minor corrections served the control. Lateral cephalograms of 38 adult patients were taken before (T0), immediately after (T1), and 3–4 years after (T2) treatment. Horizontal and vertical movement and tipping of the maxillary first molars (U6) and central incisors (U1) were measured along with skeletal craniofacial parameters at three time points to compare the two groups regarding the achieved treatment effects and their stability.

Results
Total arch distalization therapy led to 4.2 mm of distal movement of U6 without distal crown tipping (0.6° of axis change) and 3.3° of occlusal plane steepening. Over an average retention period of 42 months, maxillary total arch distalization provided high stability of treatment results, showing the same amount of mesial movement (0.7 mm) as the control group.

Conclusions
In Class II treatment, miniscrew-anchored maxillary total arch distalization can provide stable distal movement of the maxillary first molars and central incisors.
Association of BMI, Fitness, and Mortality in Patients With Diabetes: Evaluating the Obesity Paradox in the Henry Ford Exercise Testing Project (FIT Project) Cohort
Authors: Whelton Seamus P. , McAuley Paul A. , Dardari Zeina , Orimoloye Olusola A. , Brawner Clinton A. , Ehrman Jonathan K. , Keteyian Steven J. , Al-Mallah Mouaz , Blaha Michael J. 
Published: January 2020

OBJECTIVE
To determine the effect of fitness on the association between BMI and mortality among patients with diabetes.

RESEARCH DESIGN AND METHODS
We identified 8,528 patients with diabetes (self-report, medication use, or electronic medical record diagnosis) from the Henry Ford Exercise Testing Project (FIT Project). Patients with a BMI &lt;18.5 kg/m2 or cancer were excluded. Fitness was measured as the METs achieved during a physician-referred treadmill stress test and categorized as low (&lt;6), moderate (6–9.9), or high (≥10). Adjusted hazard ratios for mortality were calculated using standard BMI (kilograms per meter squared) cutoffs of normal (18.5–24.9), overweight (25–29.9), and obese (≥30). Adjusted splines centered at 22.5 kg/m2 were used to examine BMI as a continuous variable.

RESULTS
Patients had a mean age of 58 ± 11 years (49% women) with 1,319 deaths over a mean follow-up of 10.0 ± 4.1 years. Overall, obese patients had a 30% lower mortality hazard (P &lt; 0.001) compared with normal-weight patients. In adjusted spline modeling, higher BMI as a continuous variable was predominantly associated with a lower mortality risk in the lowest fitness group and among patients with moderate fitness and BMI ≥30 kg/m2. Compared with the lowest fitness group, patients with higher fitness had an ∼50% (6–9.9 METs) and 70% (≥10 METs) lower mortality hazard regardless of BMI (P &lt; 0.001).

CONCLUSIONS
Among patients with diabetes, the obesity paradox was less pronounced for patients with the highest fitness level, and these patients also had the lowest risk of mortality.
The Analysis of Toxicological Situation According to Three Specialized Centers of Russian Federation
Authors: Shikalova I. A. , Lodyagin A. N. , Barsukova I. M. , Nasibullina A. R. , Kalloyda D. Y. 
Published: January 2020

The relevance of the study is associated with the exceptional medical and social significance of the issues of toxicological assistance. In order to improve toxicological assistance to the population, we analyzed the dynamics of patient admission to major toxicological centers in St. Petersburg, Novosibirsk and Kazan in 2011–2017, which revealed a significant increase in the number of patients with a toxicological pathology and unidirectional changes in the structure of acute poisoning. We used statistical and analytical research methods. According to the results of the study, in all three centers the proportion of poisoning by narcotic substances increased, and the qualitative characteristics of poisoning changed (compared to 2011). Poisonings with opioid alkaloids and heroin haven’t been substantially found recently; the main proportion of poisonings was associated with the use of synthetic drugs (phencyclidines, piperazines, synthetic cathinones, synthetic cannabinoids, amphetamines, γ-butyrolactone and 1,4-butanediol, etc.). The proportion of patients with ethanol poisoning increased significantly: the number grew by 2.5 times in St. Petersburg, 3.0 times in Novosibirsk and 30% in Kazan. At the same time, the number of drug poisoning decreased in all three centers by an average of 20–30%. The number of carbon monoxide poisoning has also decreased in St. Petersburg and Novosibirsk. Data were obtained on some regional features of poisoning. The prevalence of poisoning by cauterizing agents in Novosibirsk and by plant poisons in Kazan. Despite a decline of mortality, the absolute number of deaths by acute poisoning during the study period increased. The study resulted in an attempt to identify the main problems and tasks of the toxicological service at present and to develop mechanisms for its improvement, taking into account modern changes in the volumes and structure of acute poisonings.Authors declare lack of the conflicts of interests.
The Effect of Telemedicine Consultation on Outcomes in Patients with Intracerebral Hemorrhage
Authors: Alasheyev A. M. , Smolkin A. A. , Prazdnichkova E. V. , Belkin A. A. 
Published: January 2020

RELEVANCE. Telemedicine solves the problem of the availability of highly qualified personnel at the decision-making stage in the management of patients with intracerebral hemorrhage. AIM OF STuDY We set out to evaluate the effect of teleconsultation on outcomes in patients with intracerebral hemorrhage 30 days after the event.MATERIAL AND METHODS. A prospective, open, nonrandomized clinical trial in two parallel groups. The first group included adult patients up to 80 years of age with a hemorrhagic stroke from 4 to 36 points according to NIHSS due to unilateral supratentorial intracerebral hematoma of non-aneurysmal genesis, who were examined by a neurosurgeon and resuscitator of the Regional Vascular Center in a ward. The second group included similar patients, but they received telemedicine consultation of the above specialists. The primary endpoint of the study was mortality 30 days after the onset of the stroke. The hypothesis of non-superiority was tested where the 95% confidence interval (CI) for the difference in mortality between the groups should not go over 15 percentage points.RESULTS. A total of 140 patients (70 in each group) with intracerebral hematomas were studied. Mortality in the bedside group was 14.3% (CI 7.1%; 24.7%), and in the remote group it was 25.7% (16.0%; 37.6%), p=0.091. However, there was no evidence of superiority, since the difference between the groups in mortality was 11.4 with CI from –0.07 to 24.5 percentage points, which was beyond the predefined limit.CONCLUSIONS. At the current level of development of medicine and information technology, telemedicine cannot fully replace the traditional (bedside) consultation of an expert level of neurosurgeon and neuroresuscitator in patients with intracerebral hematomas.Authors declare lack of the conflicts of interests.
Endovascular Treatment of Patients with Popliteal Artery Aneurysms (a Literature Review)
Authors: Prozorov S. A. 
Published: January 2020

The purpose of this review is to evaluate the results endovascular treatment of popliteal artery aneurysms. Endovascular treatment using stent grafts is a safe and effective alternative to open surgical repair, has a lower wound complication rate and shorter length of hospital stay, satisfactory technical and clinical results even at long-term follow-up. In patients requiring long segment coverage or numerous stents, the poor state of distal blood flow may increase the risk of failure. Careful patient selection, proper operative technique and adequate sizes of stent grafts are required for good outcomes.Author declare lack of the conflicts of interests.
O.I. Glazova and Her Contribution to the Development of Domestic Emergency Clinical Toxicology
Authors: Goldfarb Y. S. , Kabanova S. A. , Potskhveriya M. M. , Sleptsov V. I. 
Published: January 2020

The biography of Olga Ivanovna Glazova, doctor of medical sciences, honored doctor of the RSFSR, member of the Scientific Council of the N.V. Sklifosovsky Research Institute, is an example of an exceptionally successful diversification of scientific activity, both in the field of cardiology and clinical toxicology, which is the new direction of Russian medicine.There are suggestions in the works of O.I. Glazova similar to modern ideas of acute poisonings (AP), as confirmed by later publications in this field. The pathogenetic approach to the study of AP was considered by O.I. Glazova from the perspective of the teachings of I.P. Pavlov about the body as a single entity, and the action of the poison hypothetically dependent on its concentration in the blood. She emphasized the need for the early removal of poison from the body to prevent the adverse course of poisoning. The role of antidote therapy as an example of a detoxification approach to the treatment of AP was noted, while antidotes for parenteral administration were recommended in order to increase the effectiveness of detoxification.Some thoughts were expressed about the dependence of the toxic effects of poisons on physical and chemical properties, as well as similar ideas about the quantitative measure of poisoning, selective and situational toxicity, the presence of concentration, space and temporal factors in the pathogenesis of poisoning. The systematization of the AP was presented.Thus, O.I. Glazova made a significant contribution to the study of AP thanks to her enthusiasm, constant creative eagerness and high professional competence, which contributed to a significant growth the role of representatives of the emergency medical clinic in AP treatment, and in turn positively affected the regularity and quality of further research in this area.Authors declare lack of the conflicts of interests.
Clinical Profile and Management of Peritonsillar Abscess in a Sub Saharan Africa
Authors: Adegbiji Waheed Atilade , Olajide Gabriel Toye , Adebayo Aluko AbdulAkeem 
Published: January 2020

Background: Peritonsillar abscess is a common pathology that presents to an otolaryngologist with poor documentation especially in developing countries.
The aim of this study was to describe the clinical profile and management of peritonsillar abscess in our practice.
Material and Method: This was a retrospective study of patients presenting to our Ear, Nose and Throat facility with diagnosis of peritonsillar abscess. Information obtained includes detailed demographic characteristics, clinical findings and management of the patients. All obtained data were collated, entered into computer system and analyzed using SPSS version 18.0.
Results: Prevalence of peritonsillar abscess was 0.2%. There were 38.9% males and male to female ratio was 1:1.6. Duration of illness at presentation with more than 1 week was 75.9% and single episode occurred in 85.2%. Right peritonsillar abscess accounted for 66.7% and aspirated pus of more than 5 ml was recorded in 48.1%. Majority (87.0%) of the patients was referred and 42.6% of such referral is by family physician. Patients seen in ear, nose and throat outpatient clinic were 83.3%.
Common symptoms at presentation were fever, sore throat, odynophagia and otalgia in 100%, 94.4%, 90.7% and 59.3% respectively. All the patients (100%) had enlarged tonsils and with deviated uvula on clinical examination followed by 98.1% exudate on the tonsils and 31.5% trismus. Test aspirate confirmed peritonsillar abscess in 68.5% and all revealed growth of bacteria. Common isolated bacteria were 35.2% Streptococcus species and 11.1% Staphyloccocus aureus.
Isolated Streptococcus species and Staphylococcus aureus had 100% sensitivity to cefuroxime, gentamicin, azithromycin, ceftazidine, Amoxicillin and Streptomycin.
Prior prehospital treatment was received by 81.5% patients. Hospital treatments were surgical intervention and medical treatment in 90.7% and 100% respectively. Recurrences occurred in 3.7% during followed up.
Conclusion: Peritonsillar abscess are common disorder with female preponderance in this study. The prevalence recorded in this study was 0.2%. It usually mimic other causes of fever hence eye index of suspicion is essential. Surgical treatment remains the effective mode of management in our study.
PEMETAAN MIKROZONASI DAERAH RAWAN GEMPABUMI MENGGUNAKAN METODE HVSR DAERAH PAINAN SUMATERA BARAT
Authors: Wulandari Asri , Suharno Suharno , Rustadi Rustadi 
Published: January 2020

Regional Painan, the distric of Pesisir Selatan, the province of west Sumatera is one of the areas with high risk disaster prone. This study aims attempts to maped the disaster prone area of the Painan region based on the dominant frequency value, Vs30, PGA and amplification and to know the value of ground movement from the area. By using the HVSR method (Horizontal to Vertical Spectra Ratio) expected to assist to zone the regions. Based on the research that has been done, it is known that the Painan area, West Sumatera, have values of dominant frequency between 0.6 to 12.07 Hz. As for the value Vs30 between 73.08 to 1449 m/s and the amplification values between 0.47 to 6.01. The PGA value for Painan region between 0.034 to 0.063 g. Based on the analysis that has been done by correlating the four zoning map, it is known that the area which has a high risk of earthquake disaster that is estimated to coastal areas. This is supported by the dominant low frequency value and the value Vs30 small and PGA of high value. The amplification value of this region is divided into four zones, areas that have amplification is very high being around the beach and composed by rock alluvial, the value of amplification of high contained in nearly all the regions Painan while amplification medium and low are the small area of Painan and the small area of Bungo Pasang Salido because based on the geological map of the area is composed of two types of rocks are alluvial and rock Painan Formations.