bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detecting Social and Behavioral Determinants of Health with Structured and Free-Text Clinical Data
Authors: Feller Daniel J. , Bear Don't Walk IV Oliver J. , Zucker Jason , Yin Michael T. , Gordon Peter , Elhadad Noémie 
Published: March 2020

Abstract
Background Social and behavioral determinants of health (SBDH) are environmental and behavioral factors that often impede disease management and result in sexually transmitted infections. Despite their importance, SBDH are inconsistently documented in electronic health records (EHRs) and typically collected only in an unstructured format. Evidence suggests that structured data elements present in EHRs can contribute further to identify SBDH in the patient record.
Objective Explore the automated inference of both the presence of SBDH documentation and individual SBDH risk factors in patient records. Compare the relative ability of clinical notes and structured EHR data, such as laboratory measurements and diagnoses, to support inference.
Methods We attempt to infer the presence of SBDH documentation in patient records, as well as patient status of 11 SBDH, including alcohol abuse, homelessness, and sexual orientation. We compare classification performance when considering clinical notes only, structured data only, and notes and structured data together. We perform an error analysis across several SBDH risk factors.
Results Classification models inferring the presence of SBDH documentation achieved good performance (F1 score: 92.7–78.7; F1 considered as the primary evaluation metric). Performance was variable for models inferring patient SBDH risk status; results ranged from F1 = 82.7 for LGBT (lesbian, gay, bisexual, and transgender) status to F1 = 28.5 for intravenous drug use. Error analysis demonstrated that lexical diversity and documentation of historical SBDH status challenge inference of patient SBDH status. Three of five classifiers inferring topic-specific SBDH documentation and 10 of 11 patient SBDH status classifiers achieved highest performance when trained using both clinical notes and structured data.
Conclusion Our findings suggest that combining clinical free-text notes and structured data provide the best approach in classifying patient SBDH status. Inferring patient SBDH status is most challenging among SBDH with low prevalence and high lexical diversity.
Unraveling the Influence of Common von Willebrand factor variants on von Willebrand Disease Phenotype: An Exploratory Study on the Molecular and Clinical Profile of von Willebrand Disease in Spain Cohort
Authors: Borràs Nina , Garcia-Martínez Iris , Batlle Javier , Pérez-Rodríguez Almudena , Parra Rafael , Altisent Carme , López-Fernández María Fernanda , Costa Pinto Joana , Batlle-López Fernando , Cid Ana Rosa , Bonanad Santiago , Cabrera Noelia , Moret Andrés , Mingot-Castellano María Eva , Navarro Nira , Pérez-Montes Rocío , Marcellini Shally , Moreto Ana , Herrero Sonia , Soto Inmaculada , Fernández-Mosteirín Núria , Jiménez-Yuste Víctor , Alonso Nieves , de Andrés-Jacob Aurora , Fontanes Emilia , Campos Rosa , Paloma María José , Bermejo Nuria , Berrueco Rubén , Mateo José , Arribalzaga Karmele , Marco Pascual , Palomo Ángeles , Castro Quismondo Nerea , Iñigo Belén , del Mar Nieto María , Vidal Rosa , Martínez María Paz , Aguinaco Reyes , Tenorio Maria , Ferreiro María , García-Frade Javier , Rodríguez-Huerta Ana María , Cuesta Jorge , Rodríguez-González Ramón , García-Candel Faustino , Dobón Manuela , Aguilar Carlos , Corrales Irene , Vidal Francisco 
Published: March 2020

AbstractThe clinical diagnosis of von Willebrand disease (VWD), particularly type 1, can be complex because several genetic and environmental factors affect von Willebrand factor (VWF) plasma levels. An estimated 60% of the phenotypic variation is attributable to hereditary factors, with the ABO blood group locus being the most influential. However, recent studies provide strong evidence that nonsynonymous single nucleotide variants (SNVs) contribute to VWF and factor VIII phenotypic variability in healthy individuals. This study aims to investigate the role of common VWF SNVs on VWD phenotype by analyzing data from 219 unrelated patients included in the “Molecular and Clinical Profile of von Willebrand Disease in Spain project.” To that end, generalized linear mixed-effects regression models were fitted, and additive and epistatic analyses, and haplotype studies were performed, considering five VWD-related measures (bleeding score, VWF:Ag, VWF:RCo, factor VIII:C, and VWF:CB). According to these analyses, homozygotes: for p.Thr789Ala(C) would be expected to show 39% higher VWF:Ag levels; p.Thr1381Ala(C), 27% lower VWF:Ag levels; and p.Gln852Arg(C), 52% lower VWF:RCo levels. Homozygotes for both p.Thr789Ala(C) and p.Gln852Arg(T) were predicted to show 185% higher VWF:CB activity, and carriers of two copies of the p.Thr1381Ala(T)/p.Gln852Arg(T) haplotype would present a 100% increase in VWF:RCo activity. These results indicate a substantial effect of common VWF variation on VWD phenotype. Although additional studies are needed to determine the true magnitude of the effects of SNVs on VWF, these findings provide new evidence regarding the contribution of common variants to VWD, which should be taken into account to enhance the accuracy of the diagnosis and classification of this condition. ClinicalTrials.gov identifier: NCT02869074.
Endothelial CD40 Mediates Microvascular von Willebrand Factor-Dependent Platelet Adhesion Inducing Inflammatory Venothrombosis in ADAMTS13 Knockout Mice
Authors: Tahir Sibgha , Wagner Andreas H. , Dietzel Steffen , Mannell Hanna , Pircher Joachim , Weckbach Ludwig T. , Hecker Markus , Pohl Ulrich 
Published: March 2020

Abstract
Background von Willebrand factor (vWF) plays an important role in platelet activation. CD40–CD40 ligand (CD40L) induced vWF release has been described in large vessels and cultured endothelium, but its role in the microcirculation is not known. Here, we studied whether CD40 is expressed in murine microvessels in vivo, whether CD40L induces platelet adhesion and leukocyte activation, and how deficiency of the vWF cleaving enzyme ADAMTS13 affects these processes.
Methods and Results The role of CD40L in the formation of beaded platelet strings reflecting their adhesion to ultralarge vWF fibers (ULVWF) was analyzed in the murine cremaster microcirculation in vivo. Expression of CD40 and vWF was studied by immunohistochemistry in isolated and fixed cremasters. Microvascular CD40 was only expressed under inflammatory conditions and exclusively in venous endothelium. We demonstrate that CD40L treatment augmented the number of platelet strings, reflecting ULVWF multimer formation exclusively in venules and small veins. In ADAMTS13 knockout mice, the number of platelet strings further increased to a significant extent. As a consequence extensive thrombus formation was induced in venules of ADAMTS13 knockout mice. In addition, circulating leukocytes showed primary and rapid adherence to these platelet strings followed by preferential extravasation in these areas.
Conclusion CD40L is an important stimulus of microvascular endothelial ULVWF release, subsequent platelet string formation and leukocyte extravasation but only in venous vessels under inflammatory conditions. Here, the lack of ADAMTS13 leads to severe thrombus formation. The results identify CD40 expression and ADAMTS13 activity as important targets to prevent microvascular inflammatory thrombosis.
Early Onset Severe Hypertensive Disease in Pregnancy and Screening for Antiphospholipid Syndrome
Authors: Sobhani Nasim C. , Shulman Rachel , Tran Erin E. , Gonzalez Juan M. 
Published: March 2020

Abstract
Objective Although preterm delivery (PTD) before 34 weeks for severe hypertensive disease is a diagnostic criterion for antiphospholipid syndrome (APS), there is no consensus regarding testing for antiphospholipid antibodies (aPL) in this setting. We aim to describe the frequency of and the characteristics associated with inpatient aPL testing in this population.
Study Design In this retrospective study of PTD before 34 weeks for severe hypertensive disease, charts were reviewed for aPL testing, gestational age at delivery, fetal complications, and severity of maternal disease. Wilcoxon rank-sum test, Fisher's exact, and chi-squared tests were used for analyses of continuous and categorical variables, and multivariate logistic regression for adjusted odds ratios.
Results Among 133 cases, 14.3% had APS screening via aPL testing. Screened patients delivered earlier than unscreened patients (28.9 vs. 31.7 weeks, p <0.001). Each additional week of gestation was associated with a 39% decrease in the odds of screening (95% confidence interval: 0.43–0.85). There were no other differences between the groups.
Conclusion APS screening after PTD for severe hypertensive disease is uncommon but more likely with earlier PTD. Despite conflicting recommendations from professional organizations, prior studies demonstrate contraceptive, obstetrical, and long-term risks associated with APS, suggesting that we should increase our screening efforts.
Persistence and Extent of Neonatal Brachial Plexus Palsy: Association with Number of Maneuvers and Duration of Shoulder Dystocia
Authors: Doty Morgen S. , Chauhan Suneet P. , Chang Kate W.-C. , Al-Hafez Leen , McGovern Connie , Yang Lynda J.-S. , Blackwell Sean C. 
Published: March 2020

Abstract
Objective The main objective of this article is to determine if persistence of neonatal brachial plexus palsy (NBPP) following shoulder dystocia was associated with maneuvers used or duration of impacted shoulder.
Study Design Retrospective review of children with NBPP and documented shoulder dystocia. Student t-tests and chi-squared tests were used to compare outcomes when shoulder dystocia resolved with > 3 versus ≤ 3 maneuvers or duration > versus ≤ 120 seconds. Relative risk (RR) with 95% confidence intervals (CI) was calculated.
Results Among 46 children with NBPP and shoulder dystocia, incidence of persistence was significantly higher at 2 years of age when > 3 versus ≤ 3 maneuvers were used (100 vs. 62%; RR: 1.6, 95% CI: 1.2–2.2). When resolution of impacted shoulder lasted >120 versus ≤ 120 seconds, NBPP at 2 years was significantly more likely (100 vs. 63%; RR: 1.6, 95% CI: 1.1–2.2). Injury to all five nerves of the brachial plexus was more likely if standard deviation lasted > 120 versus ≤ 120 seconds (RR: 2.2; 95% CI: 1.03–4.6).
Conclusion Though the number of maneuvers used and duration of shoulder dystocia are associated with persistence of NBPP, the retrospective nature of the study of a selective cohort precludes recommendations changing the current management of shoulder dystocia.
Programming colloidal bonding using DNA strand-displacement circuitry
Authors: Zhou Xiang , Yao Dongbao , Hua Wenqiang , Huang Ningdong , Chen Xiaowei , Li Liangbin , He Miao , Zhang Yunhan , Guo Yijun , Xiao Shiyan , Bian Fenggang , Liang Haojun 
Published: March 2020

Significance
We developed an enthalpy-mediated strategy to control dynamic pathways in colloidal assembly by working at constant temperature, which provides a different option to circumvent metastability that normally causes disordered structures. Using this tractable approach allows colloidal bonding to be programmed for synchronization with colloid assembly, thereby realizing the optimal programmability of DNA-functionalized colloids. Moreover, the dynamic conversion of the colloidal identity can be easily achieved using this method, i.e., the conversion of colloid-A to colloid-B during colloidal assembly. This approach represents an important step for nanoscientists to manipulate colloidal bonds to create complex and functional nanoscale materials, just as chemists manipulate atomic bonds to synthesize complex and functional molecules.
Active volume regulation in adhered cells
Authors: Adar Ram M. , Safran Samuel A. 
Published: March 2020

Significance
Living cells regulate their volume using a diverse set of mechanisms to maintain their structural and functional integrity. The most widely used mechanism to control cell volume is active ion transport. Recent experiments on adhered cells reveal that their volume is significantly reduced as their basal area is increased. Our physical theory includes electrostatics and cell activity to obtain the osmotic pressure within the cell. We predict a generic relation for how adhered cells regulate their volume in response to changes in their basal area. The theory is in agreement with the recent experiments on different cell types.
Robot-Mediated Interviews
Authors: Wood Luke Jai , Dautenhahn Kerstin , Rainer Austen , Robins Ben , Lehmann Hagen , Syrdal Dag Sverre 
Published: March 2020

Abstract
In recent years the possibility of using humanoid robots to perform interviews with children has been explored in
a number of studies. This paper details a study in which a potential real-world user trialled a Robot-Mediated Interviewing system
with children to establish if this approach could realistically be used in a real-world context. In this study a senior
educational psychologist used the humanoid robot Kaspar to interview ten primary school children about a video they had watched
prior to the interview. We conducted a pre and post interview with the educational psychologist before and after using the system
to establish how the system worked for him and the perceived potential for real-world applications. The educational psychologist
successfully used the system to interview the children and believed that principally using a small humanoid robot to interview
children could be useful in a real-world setting provided the system was developed further.
Final report of the CCEM-K2.2012 key comparison of resistance standards at 10 MΩ and 1 GΩ.
Authors: Sanchez Carlos , Wendler Kai 
Published: March 2020

An international comparison of dc resistance at 10 MΩ and 1 GΩ was carried out under the framework of the Mutual Recognition Arrangement (MRA) of the Comité Consultatif d'Électricité et Magnétisme (CCEM). The comparison was piloted by the National Research Council of Canada (NRC) with the participation of 12 National Metrology Institutes (NMIs). Two 10 MΩ resistors (Measurements International, model 9331) and two 1 GΩ resistors (Measurements International, model 9331S) were used as travelling standards. Although the uncertainty at 10 MΩ was limited by the stability of the travelling standards, the comparison achieved a reduction in the uncertainties of the degrees of equivalence relative to the 2002 CCEM-K2 comparison, especially at 1 GΩ where the improvement was quite significant.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCEM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Statistical method in quark combination model *
Authors: Yang Yang-Guang , Song Jun , Shao Feng-Lan , Liang Zuo-Tang , Wang Qun 
Published: March 2020

Abstract
We present a new method for solving the probability distribution for baryons, antibaryons, and mesons at the hadronization of the constituent quark and antiquark system. The hadronization is governed by the quark combination rule in the quark combination model developed by the Shandong Group. We employ the method of the generating function to derive the outcome of the quark combination rule, which is significantly simpler and easier to generalize than the original method. Furthermore, we use the formula of the quark combination rule and its generalization to study the property of the multiplicity distribution of net-protons. Taking a naive case of quark number fluctuations and correlations at hadronization, we calculate ratios of multiplicity cumulants of final-state net-protons and discuss the potential applicability of the quark combination model by studying hadronic multiplicity fluctuations and the underlying phase transition property in relativistic heavy-ion collisions.
Comparative study of the forward and backward methods for calculating jet properties in pp collisions at √s=7 TeV *
Authors: Yan Yu-Liang , Limphirat Ayut , Zhou Dai-Mei , Srisawad Pornrad , Yan Yupeng , Yang Chunbin , Cai Xu , Sa Ben-Hao 
Published: March 2020

Abstract
We propose a forward method based on PYTHIA6.4 to study the jet properties in ultra-relativistic pp collisions. In the forward method, the partonic initial states are first generated with PYTHIA6.4 and then hadronized in the Lund string fragmentation model, and finally the hadronic jets are constructed from the created hadrons. Jet properties calculated with the forward method for pp collisions at

=7 TeV are comparable to those calculated with the usual anti-

algorithm (backward method) in PYTHIA6.4. The comparison between the backward and forward methods may contribute to the understanding of the partonic origin of jets in the backward method.
Modeling the quasi-periodic oscillation of Swift J1644+57
Authors: Zheng Meng-Meng , Yi Shuang-Xi , Wang Fa-Yin , Zou Yuan-Chuan 
Published: March 2020

Abstract
A 200-second X-ray quasi-periodicity in the 2 – 8 keV band from Swift J1644+57 was found by Reis et al. From the onset time of quasi-periodic oscillation (QPO), we show that Swift J1644+57 is a plunging event. This QPO may be related to discrete clumps from the accretion disk falling into a supermassive black hole, then the outflow in the jet may be also discontinuous. We estimate the lifetime of clumps to be about several hundreds seconds and the fraction of clumpy ejecta to be about 30% from the QPO. The other possible model involves the interface between the inflow and jet magnetosphere in the magnetically choked accretion flow. Theory and numerical simulations indicate that a magnetic Rayleigh-Taylor and Kelvin-Helmholtz unstable magnetospheric interface can produce a jet-disk QPO mechanism. This event may be the first evidence of jet-disk QPO. From observations, the two models are comparable.
The global distribution of seagrass meadows
Authors: McKenzie Len J , Nordlund Lina M , Jones Benjamin L , Cullen-Unsworth Leanne C , Roelfsema Chris , Unsworth Richard K F 
Published: March 2020

Abstract
Seagrass meadows globally are under pressure with worldwide loss and degradation, but there is a growing recognition of the global importance of seagrass ecosystem services, particularly as a major carbon sink and as fisheries habitat. Estimates of global seagrass spatial distribution differ greatly throughout the published literature, ranging from 177 000 to 600 000 km2 with models suggesting potential distribution an order of magnitude higher. The requirements of the Paris Climate Agreement by outlining National Determined Contributions (NDC’s) to reduce emissions is placing an increased global focus on the spatial extent, loss and restoration of seagrass meadows. Now more than ever there is a need to provide a more accurate and consistent measure of the global spatial distribution of seagrass. There is also a need to be able to assess the global spread of other seagrass ecosystem services and in their extension, the values of these services. In this study, by rationalising and updating a range of existing datasets of seagrass distribution around the globe, we have estimated with Moderate to High confidence the global seagrass area to date as 160 387 km2, but possibly 266 562 km2 with lower confidence. We break this global estimate down to a national level with a detailed analysis of the current state of mapped distribution and estimates of seagrass area per country. Accurate estimates, however, are challenged by large areas remaining unmapped and inconsistent measures being used. Through the examination of current global maps, we are able to propose a pathway forward for improving mapping of this important resource. More accurate measure of global #seagrass distribution, critical for assessing current state and trends
PI/NCC Carbon Membrane: Effect of Additives loading Towards Hydrogen Separation
Authors: Sazali N , Mamat R , Siregar J P , Gunawan T , Salleh W N W , Nordin N A H M 
Published: March 2020

Abstract
Incorporating thermally labile polymer-based additives is a facile and practical approach in developing superior carbon membranes. In this study, three different thermally labile polymers, microcrystalline cellulose (MCC), nanocrystalline cellulose (NCC), and polyvinylpyrrolidone (PVP), were introduced separately to P84-copolyimide (PI) solution as additive and their impact on membrane performance were investigated. Firstly, NCC was added as the membrane pore former for hydrogen gas (H2) separation. The addition of NCC significantly increased pore channels in the membrane, hence contributed to high gas permeance and selectivity. The tests involving pure H2 and N2 permeation were carried out at room temperature. Carbon membranes carbonized at a final temperature of 800°C with the heating rate of 3°C/min under Ar flow achieved the greatest H2/N2 selectivity of 434.68±1.39, hence proving the potential of NCC as a good additive.
ADVANCED IN CARBON MEMBRANE BY RELATING TO COATING-CARBONIZATION-CYCLES FOR OXYGEN PERFORMANCE
Authors: Sazali N , Salleh W N W , Ismail N H , Kumaran K , Othman M H D , Harun Z 
Published: March 2020

Abstract
This work discusses the creation and assessment of rounded carbon membrane arranged from P84 co-polyimide mixes with Nanocrystalline cellulose (NCC). In light of earlier examinations, it defined the theory that rounded carbon membrane execution can be controlled by controlling the carbonization parameters. The focal point of this investigation is to acquaint compelling dip-coating strategies with deliver superior rounded carbon membrane. In light of the result of this examination, the coating carbonization cycle (1, 2, 3, and multiple times) has been distinguished as real effect on the separation productivity. Gas separation performance and transport instrument of the carbon membranes were enough assessed by single gas permeation of O2, and N2. In this exploration, use of 2-cycles of coating carbonization has brought about carbon membrane with the most elevated selectivity and O2 penetrability which are 9.29±2.54 and 29.92±1.44 GPU, individually.
Growth and yield of Pleurotus ostreatus using sugarcane bagasse as an alternative substrate in Malaysia
Authors: Ahmad Zakil F , Muhammad Hassan K H , Mohd Sueb M S , Isha R 
Published: March 2020

Abstract
This paper looks at the feasibility of using sugarcane bagasse (SGB) for the cultivation of Pleurotus ostreatus (oyster mushrooms) as an alternative for rubber tree sawdust (RS). Three different compositions of oil palm trunk and rubber tree sawdust were studied with each composition having three replicates. A substrate containing only rubber tree sawdust acted as the control variable. The substrates were supplemented with 5% rice bran and 1.5% calcium carbonate. There are four steps involved in the cultivation of P. ostreatus which were bagging, sterilization, spawning and harvesting the substrates. The mycelia growth, spawn run, pin head formation, yield and biological efficiency were observed. The 100% composition of RS gave the best yield in terms of the mean height of stipe, which was 7.75cm. The mean fresh weight of sawdust was the highest with 50.4g with the number of fruiting bodies around 6. The least yield was recorded for 50% composition of substrates with a mean height of stipe 9.12cm. Among the substrates used, the RS showed the highest biological efficiency with 56.3% followed by 45.1% and 44.8% RS having mixed compositions of 25% and 50% SGB substrates, respectively. Hence, it is proven that in terms of quantity and quality, the unmixed substrates produced better edible mushrooms. However, the results obtained by SGB also showed a great potential as an alternative substrate for the cultivation of P. ostreatus when mixed with RS.