bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolution of gas disc–embedded intermediate mass ratio inspirals in theLISAband
Authors: Derdzinski A , D’Orazio D , Duffell P , Haiman Z , MacFadyen A 
Published: December 2020

ABSTRACTAmong the potential milliHz gravitational wave (GW) sources for the upcoming space-based interferometer LISA are extreme- or intermediate-mass ratio inspirals (EMRI/IMRIs). These events involve the coalescence of supermassive black holes in the mass range 105M⊙ ≲ M ≲ 107M⊙ with companion BHs of much lower masses. A subset of E/IMRIs are expected to occur in the accretion discs of active galactic nuclei (AGNs), where torques exerted by the disc can interfere with the inspiral and cause a phase shift in the GW waveform. Here we use a suite of 2D hydrodynamical simulations with the moving-mesh code disco to present a systematic study of disc torques. We measure torques on an inspiralling BH and compute the corresponding waveform deviations as a function of the binary mass ratio q ≡ M2/M1, the disc viscosity (α), and gas temperature (or equivalently Mach number; $\mathcal {M}$). We find that the absolute value of the gas torques is within an order of magnitude of previously determined planetary migration torques, but their precise value and sign depends non-trivially on the combination of these parameters. The gas imprint is detectable by LISA for binaries embedded in AGN discs with surface densities above $\Sigma _0\ge 10^{4-6} \rm \, g cm^{-2}$, depending on q, α, and $\mathcal {M}$. Deviations are most pronounced in discs with higher viscosities, and for E/IMRIs detected at frequencies where LISA is most sensitive. Torques in colder discs exhibit a noticeable dependence on the GW-driven inspiral rate as well as strong fluctuations at late stages of the inspiral. Our results further suggest that LISA may be able to place constraints on AGN disc parameters and the physics of disc–satellite interaction.
On the formation and stability of fermionic dark matter haloes in a cosmological framework
Authors: Argüelles Carlos R , Díaz Manuel I , Krut Andreas , Yunis Rafael 
Published: December 2020

ABSTRACT
The formation and stability of collisionless self-gravitating systems are long-standing problems, which date back to the work of D. Lynden-Bell on violent relaxation and extends to the issue of virialization of dark matter (DM) haloes. An important prediction of such a relaxation process is that spherical equilibrium states can be described by a Fermi–Dirac phase-space distribution, when the extremization of a coarse-grained entropy is reached. In the case of DM fermions, the most general solution develops a degenerate compact core surrounded by a diluted halo. As shown recently, the latter is able to explain the galaxy rotation curves, while the DM core can mimic the central black hole. A yet open problem is whether these kinds of astrophysical core–halo configurations can form at all, and whether they remain stable within cosmological time-scales. We assess these issues by performing a thermodynamic stability analysis in the microcanonical ensemble for solutions with a given particle number at halo virialization in a cosmological framework. For the first time, we demonstrate that the above core–halo DM profiles are stable (i.e. maxima of entropy) and extremely long-lived. We find the existence of a critical point at the onset of instability of the core–halo solutions, where the fermion-core collapses towards a supermassive black hole. For particle masses in the keV range, the core-collapse can only occur for $M_{\rm vir} \gtrsim 10^{9}{\, \mathrm{M}_\odot}$ starting at zvir ≈ 10 in the given cosmological framework. Our results prove that DM haloes with a core–halo morphology are a very plausible outcome within non-linear stages of structure formation.
Metabolomic and secretomic approach to the resistance features of the fungus Aspergillus niger IOC 4687 to copper stress
Authors: Perdigão Cota de Almeida Silas , Rozas Enrique Eduardo , Oller do Nascimento Cláudio Augusto , Dias Meriellen , Mendes Maria Anita 
Published: December 2020

Abstract
Metabolomic and secretomic analyses of Aspergillus niger IOC 4687 indicated the features of resistance of this strain to copper stress. To investigate the metabolites produced under oxidative stress conditions, gas chromatography–mass spectrometry analysis was performed. The secretome principal component analysis results showed that mannitol could be the main metabolite responsible for conferring resistance to the fungus, and gluconic acid is the possible cause of copper desorption because of its chelating ability. The meta-analysis of the metabolome of A. niger IOC 4687 indicated that a low concentration of sorbitol and ribonolactone during growth may be an indicator of oxidative stress.
The role of inflammation in mesenchymal stromal cell therapy in osteoarthritis, perspectives for post-traumatic osteoarthritis: a review
Authors: Theeuwes Wessel F , van den Bosch Martijn H J , Thurlings Rogier M , Blom Arjen B , van Lent Peter L E M 
Published: December 2020

Abstract
OA is a complex and highly prevalent degenerative disease affecting the whole joint, in which factors like genetic predisposition, gender, age, obesity and traumas contribute to joint destruction. ∼50–80% of OA patients develop synovitis. OA-associated risk factors contribute to joint instability and the release of cartilage matrix fragments, activating the synovium to release pro-inflammatory factors and catabolic enzymes in turn damaging the cartilage and creating a vicious circle. Currently, no cure is available for OA. Mesenchymal stromal cells (MSCs) have been tested in OA for their chondrogenic and anti-inflammatory properties. Interestingly, MSCs are most effective when administered during synovitis. This review focusses on the interplay between joint inflammation and the immunomodulation by MSCs in OA. We discuss the potential of MSCs to break the vicious circle of inflammation and describe current perspectives and challenges for clinical application of MSCs in treatment and prevention of OA, focussing on preventing post-traumatic OA.
The effect of sleep deprivation and restriction on mood, emotion, and emotion regulation: three meta-analyses in one
Authors: Tomaso Cara C , Johnson Anna B , Nelson Timothy D 
Published: December 2020

AbstractStudy ObjectivesNew theory and measurement approaches have facilitated nuanced investigation of how sleep loss impacts dimensions of affective functioning. To provide a quantitative summary of this literature, three conceptually related meta-analyses examined the effect of sleep restriction and sleep deprivation on mood, emotion, and emotion regulation across the lifespan (i.e. from early childhood to late adulthood).MethodsA total of 241 effect sizes from 64 studies were selected for inclusion, and multilevel meta-analytic techniques were used when applicable.ResultsThere was a moderate, positive effect of sleep loss on negative mood (g = 0.45), which was stronger for studies with younger samples, as well as a large, negative effect of sleep loss on positive mood (g = −0.94). For negative mood only, studies that used total sleep deprivation had larger effect sizes than studies that restricted sleep. After correcting for publication bias, a modest but significant negative effect for sleep loss on emotion (g = −0.11) was found; the valence of emotional stimuli did not change the direction of this effect, and type of sleep manipulation was also not a significant moderator. Finally, sleep restriction had a small, negative effect on adaptive emotion regulation (g = −0.32), but no significant impact on maladaptive emotion regulation (g = 0.14); all studies on adaptive emotion regulation were conducted with youth samples.ConclusionsSleep loss compromises optimal affective functioning, though the magnitude of effects varies across components. Findings underscore the importance of sleep for healthy affective outcomes.
How do children with autism spectrum disorder form gist memory during sleep? A study of slow oscillation–spindle coupling
Authors: Kurz Eva-Maria , Conzelmann Annette , Barth Gottfried Maria , Renner Tobias J , Zinke Katharina , Born Jan 
Published: December 2020

Abstract
Sleep is assumed to support memory through an active systems consolidation process that does not only strengthen newly encoded representations but also facilitates the formation of more abstract gist memories. Studies in humans and rodents indicate a key role of the precise temporal coupling of sleep slow oscillations (SO) and spindles in this process. The present study aimed at bolstering these findings in typically developing (TD) children, and at dissecting particularities in SO-spindle coupling underlying signs of enhanced gist memory formation during sleep found in a foregoing study in children with autism spectrum disorder (ASD) without intellectual impairment. Sleep data from 19 boys with ASD and 20 TD boys (9–12 years) were analyzed. Children performed a picture-recognition task and the Deese–Roediger–McDermott (DRM) task before nocturnal sleep (encoding) and in the next morning (retrieval). Sleep-dependent benefits for visual-recognition memory were comparable between groups but were greater for gist abstraction (recall of DRM critical lure words) in ASD than TD children. Both groups showed a closely comparable SO-spindle coupling, with fast spindle activity nesting in SO-upstates, suggesting that a key mechanism of memory processing during sleep is fully functioning already at childhood. Picture-recognition at retrieval after sleep was positively correlated to frontocortical SO-fast-spindle coupling in TD children, and less in ASD children. Critical lure recall did not correlate with SO-spindle coupling in TD children but showed a negative correlation (r = −.64, p = .003) with parietal SO-fast-spindle coupling in ASD children, suggesting other mechanisms specifically conveying gist abstraction, that may even compete with SO-spindle coupling.
Diagnostic Yield of Bronchoalveolar Lavage in Immunocompromised Children
Authors: Wong Jeff Chin Pang , Hon Kam Lun Ellis , Leung Karen Ka Yan , Qian Suyun , Leung Alexander K C 
Published: December 2020

Abstract
Results from early studies in the diagnostic yield of bronchoalveolar lavage (BAL) in immunocompromised adults and children were variable. This prospective study aimed to determine the diagnostic yield of BALs in immunocompromised children over the first 18 months of service at a newly established children’s hospital. Relationship between BAL results and changes in antimicrobial management was also studied. Twenty-one bronchoscopic BALs were performed on 18 children; 14 BALs (66.7%) yielded at least 1 pathogen and 7 (33.3%) yielded no pathogen. Two pathogens were found in 2 samples, and 1 pathogen was identified in 12 samples. Bacteria (n = 7 patients), viruses (n = 8 patients) and fungus (Pneumocycstis jirovecii in one patient) were yielded. Of the 21 BALs, 8 (38.1%) were associated with changes in antimicrobial management (Fisher’s exact test, p = 0.018). No significant side effects such as pneumothorax or pulmonary hemorrhages were observed in this series. In conclusion, BAL in immunocompromised children is rewarding and has potential to impact on antimicrobial management.
Emerging global novelty in phyllobothriidean tapeworms (Cestoda: Phyllobothriidea) from sharks and skates (Elasmobranchii)
Authors: Caira Janine N , Bueno Veronica , Jensen Kirsten 
Published: December 2020

AbstractNew genera are erected for three clades of tapeworms originally discovered using molecular sequence data. The morphological features of each are characterized after examination of specimens with light and scanning electron microscopy. Rockacestus gen. nov. parasitizes skates. Ruhnkebothrium gen. nov. parasitizes hammerhead sharks. Yamaguticestus gen. nov. parasitizes small squaliform sharks and catsharks. The novelty of these genera is supported by a taxonomically comprehensive molecular phylogenetic analysis of the D1–D3 region of the 28S rDNA gene, which, with the addition of newly generated sequence data, is the first to include representation of 15 of the 18 genera of phyllobothriideans plus the three new genera. Five new species are described from elasmobranchs in the western Atlantic Ocean, the Gulf of California, Chile, the Falkland Islands and South Africa to help circumscribe the new genera. Two of the genera provide appropriate generic homes for ten species of phyllobothriideans from catsharks and skates with uncertain generic affinities and thus resolve longstanding taxonomic issues. Given that these genera parasitize some of the most poorly sampled groups of elasmobranchs (i.e. hammerhead sharks, squaliform sharks, catsharks and skates), based on the strict degree of host specificity observed, we predict that further work on other members of these groups will yield as many as 200 additional species in these three genera of tapeworms globally. This brings the total number of genera in the Phyllobothriidea to 21.
Hearing Status Affects Children’s Emotion Understanding in Dynamic Social Situations: An Eye-Tracking Study
Authors: Tsou Yung-Ting , Li Boya , Kret Mariska E. , Frijns Johan H. M. , Rieffe Carolien 
Published: December 2020

Objectives:
For children to understand the emotional behavior of others, the first two steps involve emotion encoding and emotion interpreting, according to the Social Information Processing model. Access to daily social interactions is prerequisite to a child acquiring these skills, and barriers to communication such as hearing loss impede this access. Therefore, it could be challenging for children with hearing loss to develop these two skills. The present study aimed to understand the effect of prelingual hearing loss on children’s emotion understanding, by examining how they encode and interpret nonverbal emotional cues in dynamic social situations.

Design:
Sixty deaf or hard-of-hearing (DHH) children and 71 typically hearing (TH) children (3–10 years old, mean age 6.2 years, 54% girls) watched videos of prototypical social interactions between a target person and an interaction partner. At the end of each video, the target person did not face the camera, rendering their facial expressions out of view to participants. Afterward, participants were asked to interpret the emotion they thought the target person felt at the end of the video. As participants watched the videos, their encoding patterns were examined by an eye tracker, which measured the amount of time participants spent looking at the target person’s head and body and at the interaction partner’s head and body. These regions were preselected for analyses because they had been found to provide cues for interpreting people’s emotions and intentions.

Results:
When encoding emotional cues, both the DHH and TH children spent more time looking at the head of the target person and at the head of the interaction partner than they spent looking at the body or actions of either person. Yet, compared with the TH children, the DHH children looked at the target person’s head for a shorter time (b = −0.03, p = 0.030), and at the target person’s body (b = 0.04, p = 0.006) and at the interaction partner’s head (b = 0.03, p = 0.048) for a longer time. The DHH children were also less accurate when interpreting emotions than their TH peers (b = −0.13, p = 0.005), and their lower scores were associated with their distinctive encoding pattern.

Conclusions:
The findings suggest that children with limited auditory access to the social environment tend to collect visually observable information to compensate for ambiguous emotional cues in social situations. These children may have developed this strategy to support their daily communication. Yet, to fully benefit from such a strategy, these children may need extra support for gaining better social-emotional knowledge.
Cigarettes smoking and androgen receptor-positive breast cancer
Authors: Pizzato Margherita , Carioli Greta , Rosso Stefano , Zanetti Roberto , Negri Eva , La Vecchia Carlo 
Published: December 2020

Objectives
Cigarette smoking is related to higher levels of circulating androgens, but its association with androgen receptor (AR) status is still unaddressed.

Methods
We analysed, with a case-only approach, smoking habits according to AR status in 112 cases of invasive female breast cancer, from the Piedmont Cancer Registry. We used a multivariate logistic regression model to estimate the odds ratio (OR) and the corresponding confidence interval (CI).

Results
The OR of AR-positive breast cancer (versus AR-negative) for ever smokers (versus never) was 2.85 (95% CI 1.02–7.96).

Conclusion
Smoking is related to AR-positive breast cancer.
Family Planning Performance in Selected States and Union Territories of India: Evidence from NFHS 2019-20
Authors: Chaurasia Aalok Ranjan 
Published: December 2020

AbstractThis paper uses a new composite index to measure family planning performance in 22 states/Union Territories of India for which latest data on family planning use are available from NFHS 2019-2020. The analysis reveals that family planning performance in meeting the family planning needs of the people remains poor and there are significant inter-state/Union Territory variation in the performance. The paper calls for reinvigorating family planning efforts by treating family planning as a development strategy.
Early start of oral clarithromycin is associated with better outcome in COVID-19 of moderate severity: the ACHIEVE open-label trial
Authors: Tsiakos Konstantinos , Tsakiris Antonios , Tsibris Georgios , Voutsinas Pantazis , Panagopoulos Periklis , Kosmidou Maria , Petrakis Vasileios , Gravvani Areti , Gkavogianni Theologia , Klouras Eleftherios , Katrini Konstantina , Koufargyris Panagiotis , Rapti Iro , Karageorgos Athanassios , Vrentzos Emmanouil , Damoulari Christina , Zarkada Vagia , Sidiropoulou Chrysanthi , Artemi Sofia , Ioannidis Anastasios , Papapostolou Androniki , Michelakis Evangelos , Georgiopoulou Maria , Myrodia Dimitra-Melia , Tsiamalos Panteleimon , Syrigos Konstantinos , Chrysos George , Nitsotolis Thomas , Milionis Haralampos , Poulakou Garyphallia , Giamarellos-Bourboulis Evangelos J. 
Published: December 2020

ABSTRACTBackgroundTo study the efficacy of oral clarithromycin in moderate COVID-19.MethodsAn open-label non-randomized trial in 90 patients with COVID-19 of moderate severity was conducted between May and October 2020. The primary endpoint was defined at the end-of-treatment (EOT) as no need for hospital re-admission and no progression into lower respiratory tract infection (LRTI) for patients with upper respiratory tract infection; and as at least 50% decrease of the respiratory symptoms score the without progression into severe respiratory failure (SRF) for patients with LRTI. Viral load, biomarkers, the function of mononuclear cells, and safety were assessed.ResultsThe primary endpoint was attained in 86.7% of patients treated with clarithromycin (95% CIs 78.1-92.2%); this was 91.7% and 81.4% among patients starting clarithromycin the first 5 days from symptoms onset or later (odds ratio after multivariate analysis 6.62; p: 0.030). The responses were better for patients infected by non-B1.1 variants. Clarithromycin use was associated with decreases in circulating C-reactive protein, tumour necrosis factor-alpha and interleukin (IL)-6; by increase of Th1 to Th2 mononuclear responses; and by suppression of SARS-CoV-2 viral load. No safety concerns were reported.ConclusionsEarly clarithromycin treatment provides most of clinical improvement in moderate COVID-19 (Trial Registration: ClinicalTrials.gov, NCT04398004)
Marine community metabolomes carry fingerprints of phytoplankton community composition
Authors: Heal Katherine R. , Durham Bryndan , Boysen Angela K. , Carlson Laura T. , Qin Wei , Ribalet François , White Angelicque E. , Bundy Randelle M. , Armbrust E. Virginia , Ingalls Anitra Eiding 
Published: December 2020

ABSTRACTPhytoplankton transform inorganic carbon into thousands of biomolecules that represent an important pool of fixed carbon, nitrogen, and sulfur in the surface ocean. Metabolite production differs between phytoplankton, and the flux of these molecules through the microbial food web depends on compound-specific bioavailability to members of a wider microbial community. Yet relatively little is known about the diversity or concentration of metabolites within marine plankton. Here we compare 313 polar metabolites in 21 cultured phytoplankton species and in natural planktonic communities across environmental gradients to show that bulk community metabolomes reflect chemical composition of the phytoplankton community. We also show that groups of compounds have similar patterns across space and taxonomy suggesting that the concentrations of these compounds in the environment are controlled by similar sources and sinks. We quantify several compounds in the surface ocean that represent substantial understudied pools of labile carbon. For example, the N-containing metabolite homarine was up to 3% of particulate carbon and is produced in high concentrations by culturedSynechococcus, and S-containing gonyol accumulated up to 2.5 nM in surface particles and likely originates from dinoflagellates. Our results show that phytoplankton composition directly shapes the carbon composition of the surface ocean. Our findings suggest that in order to access these pools of bioavailable carbon, the wider microbial community must be adapted to phytoplankton community composition.IMPORTANCEMicroscopic phytoplankton transform 100 million tons of inorganic carbon into thousands of different organic compounds each day. The structure of each chemical is critical to its biological and ecosystem function, yet, the diversity of biomolecules produced by marine microbial communities remained mainly unexplored, especially small polar molecules which are often considered the currency of the microbial loop. Here we explore the abundance and diversity of small biomolecules in planktonic communities across ecological gradients in the North Pacific and within 21 cultured phytoplankton species. Our work demonstrates that phytoplankton diversity is an important determinant of the chemical composition of the highly bioavailable pool of organic carbon in the ocean, and we highlight understudied yet abundant compounds in both the environment and cultured organisms. These findings add to understanding of how the chemical makeup of phytoplankton shapes marine microbial communities where the ability to sense and use biomolecules depends on the chemical structure.
MHC Haplotyping of SARS-CoV-2 patients: HLA subtypes are not associated with the presence and severity of Covid-19 in the Israeli population
Authors: Ben Shachar Shay , Barda Noam , Manor Sigal , Israeli Sapir , Dagan Noa , Haber Adam , Carmi Shai , Balicer Ran , Zisser Bracha , Louzoun Yoram 
Published: December 2020

ABSTRACTHLA haplotypes were found to be associated with increased risk for viral infections or disease severity in various diseases, including SARS. Several genetic variants are associated with Covid-19 severity. However, no clear association between HLA and Covid-19 incidence or severity has been reported. We conducted a large scale HLA analysis of Israeli individuals who tested positive for SARS-CoV-2 infection by PCR. Overall, 72,912 individuals with known HLA haplotypes were included in the study, of whom 6,413 (8.8%) were found to have SARS-CoV-2 by PCR. a Total of 20,937 subjects were of Ashkenazi origin (at least 2/4 grandparents). One hundred eighty-one patients (2.8% of the infected) were hospitalized due to the disease. None of the 66 most common HLA loci (within the five HLA subgroups; A, B, C, DQB1, DRB1) was found to be associated with SARS-CoV-2 infection or hospitalization. Similarly, no association was detected in the Ashkenazi Jewish subset. Moreover, no association was found between heterozygosity in any of the HLA loci and either infection or hospitalization.We conclude that HLA haplotypes are not a major risk/protecting factor among the Israeli population for SARS-CoV-2 infection or severity.