bluuebunny/crossref_metadata_2025_split huggingface dataset:
Solvent‐Driven Supramolecular Wrapping of Self‐Assembled Structures
Authors: Moreno‐Alcántar Guillermo , Aliprandi Alessandro , Rouquette Remi , Pesce Luca , Wurst Klaus , Perego Claudio , Brüggeller Peter , Pavan Giovanni M. , De Cola Luisa 
Published: November 2020

AbstractSelf‐assembly relies on the ability of smaller and discrete entities to spontaneously arrange into more organized systems by means of the structure‐encoded information. Herein, we show that the design of the media can play a role even more important than the chemical design. The media not only determines the self‐assembly pathway at a single‐component level, but in a very narrow solvent composition, a supramolecular homo‐aggregate can be non‐covalently wrapped by a second component that possesses a different crystal lattice. Such a process has been followed in real time by confocal microscopy thanks to the different emission colors of the aggregates formed by two isolated PtII complexes. This coating is reversible and controlled by the media composition. Single‐crystal X‐ray diffraction and molecular simulations based on coarse‐grained (CG) models allowed the understanding of the properties displayed by the different aggregates. Such findings could result in a new method to construct hierarchical supramolecular structures.
Ultra‐low‐dose spinal anaesthesia for elective hip arthroplasty in a patient with severe pulmonary hypertension
Authors: Barnwell N. , Padfield K. 
Published: November 2020

SummaryPulmonary hypertension is a complex chronic cardiopulmonary disease. The condition is an independent risk‐factor for peri‐operative morbidity and mortality in patients undergoing non‐cardiac surgery, with mortality rates of up to 18%. Due to this, patients with pulmonary hypertension are frequently counselled against undergoing all but essential surgery. In this report, we describe the use of ultra‐low‐dose spinal anaesthetic delivered via intrathecal catheter to allow a patient with severe pulmonary hypertension to safely undergo an elective primary hip arthroplasty for osteoarthritis which was causing intolerable pain. The use of an intrathecal catheter avoided general anaesthesia in a patient who may not have tolerated positive pressure ventilation. The technique also allowed the use of ultra‐low doses of spinal anaesthesia, with the option of titrating to effect and duration of surgery. Invasive monitoring allowed proactive management of the haemodynamic effects of neuraxial anaesthesia, specifically the fall in systemic vascular resistance that may be associated with higher doses of spinal anaesthesia. While this report describes a patient with severe pulmonary hypertension, the technique may also be considered for patients with other obstructive cardiac lesions including severe aortic or mitral stenosis.
Facile preparation and flame retardancy mechanism of cyclophosphazene derivatives for highly flame‐retardant silicone rubber composites
Authors: Yang Jiacheng , Ma Wenshi , Hu Dechao , Zhang Dongqiao , Wu Li , Yang Bo , Zhang Shuanghong 
Published: November 2020

AbstractA novel and efficient flame retardant cyclophosphazene derivative Hexa (p‐acetamidophenoxy) cyclotriphosphazene (HACP) was successfully prepared via a facile one‐step reaction. The chemical structure of HACP was characterized and confirmed by FT‐IR, 1H and 13C NMR. Then the as‐prepared HACP was incorporated into addition‐cure liquid silicone rubber (ALSR) matrix to prepare highly flame‐retardant rubber composites. It was found that the incorporation of HACP can significantly enhance the flame resistance of ALSR. Typically, the ALSR composites filled with 30 phr HACP achieved UL‐94 V‐0 rating and meanwhile the total heat release and total smoke release were decreased by 26.9% and 41.5%, respectively. Moreover, the flame‐retardant mechanism of ALSR/HACP composites was investigated by TGA, Py‐GCMS, FT‐IR, SEM and EDX, confirming that HACP plays a significant role in capturing free‐radicals and forming protective layers. This work designed a novel cyclophosphazene‐based flame retardant to significantly enhance the flame retardancy of ALSR, which may offer some valuable inspiration for the fabrication of highly flame‐retardant polymer composites.
WISC‐V Profiles and Their Correlates in Children with Autism Spectrum Disorder without Intellectual Developmental Disorder: Report from the ELENA Cohort
Authors: Audras‐Torrent Lee , Miniarikova Ela , Couty Flore , Dellapiazza Florine , Berard Mathilde , Michelon Cécile , Picot Marie‐Christine , Baghdadli Amaria 
Published: November 2020

The intellectual functioning of people with autism spectrum disorder (ASD) without intellectual developmental disorder (IDD) has not been widely studied. However, marked heterogeneity in assessment measures, samples, and results has been an obstacle for the generalization of findings. We aimed to (a) describe WISC‐V intellectual functioning in a sample of children with autism spectrum disorder without intellectual developmental disorder, (b) identify WISC‐V profiles, and (c) explore whether WISC‐V intellectual functioning is related to ASD symptom severity and adaptive skills. Our sample consisted of 121 children from 6 to 16 years of age with ascertained ASD without an intellectual developmental disorder (IDD). The intellectual functioning of the participants was within the average range. Intra‐individual analysis showed that children with ASD performed better on visual than auditory working‐memory tasks. Moreover, the intellectual functioning of the participants correlated negatively with ASD symptom severity but positively with adaptive communication skills. Overall, we identified six intellectual profiles according to verbal and reasoning skills. These findings highlight the relevance of WISC‐V assessment for children with ASD without an IDD to individualize intervention, especially remediation.Lay SummaryThis study examined WISC‐V intellectual functioning in 121 children with autism spectrum disorder (ASD) without an intellectual developmental disorder (IDD). We found their intellectual functioning to be within the average, as was that of their peers with typical development (TD), and their verbal and reasoning skills were the most discriminant. In addition, the better their intellectual functioning was, the better their adaptive communication skills and the less severe their ASD symptoms. These findings highlight the relevance of WISC‐V assessment in ASD to individualize early psychological remediation. Autism Res 2021, 14: 997–1006. © 2020 International Society for Autism Research, Wiley Periodicals, LLC
Assessing bio‐oil co‐processing routes as CO2 mitigation strategies in oil refineries
Authors: Yáñez Édgar , Meerman Hans , Ramírez Andrea , Castillo Édgar , Faaij Andre 
Published: November 2020

AbstractThe oil industry needs to reduce CO2 emissions across the entire lifecycle of fossil fuels to meet environmental regulations and societal requirements and to sustain its business. With this goal in mind, this study aims to evaluate the CO2 mitigation potential of several bio‐oil co‐processing pathways in an oil refinery. Techno‐economic analysis was conducted on different pathways and their greenhouse gas (GHG) mitigation potentials were compared. Thirteen pathways with different bio‐oils, including vegetable oil (VO), fast pyrolysis oil (FPO), hydro‐deoxygenated oil (HDO), catalytic pyrolysis oil (CPO), hydrothermal liquefaction oil (HTLO), and Fischer–Tropsch fuels, were analyzed. However, no single pathway could be presented as the best option. This would depend on the criteria used and the target of the co‐processing route. The results obtained indicated that up to 15% of the fossil‐fuel output in the refinery could be replaced by biofuel without major changes in the core activities of the refinery. The consequent reduction in CO2 emissions varied from 33% to 84% when compared with pure equivalent fossil fuels replaced (i.e., gasoline and diesel). Meanwhile, the production costs varied from 17 to 31€/GJ (i.e., 118–213$/bbleq). Co‐processing with VO resulted in the lowest overall performance among the options that were evaluated while co‐processing HTLO in the hydrotreatment unit and FPO in the fluid catalytic cracking unit showed the highest potential for CO2 avoidance (69% of refinery CO2 emissions) and reduction in CO2 emissions (84% compared to fossil fuel), respectively. The cost of CO2 emissions avoided for all of the assessed routes was in the range of €99–651 per tCO2. © 2020 The Authors. Biofuels, Bioproducts, and Biorefining published by Society of Chemical Industry and John Wiley & Sons, Ltd.
A multi‐institutional randomized controlled trial comparing first‐generation transrectal high‐resolution micro‐ultrasound with conventional frequency transrectal ultrasound for prostate biopsy
Authors: Pavlovich C. P. , Hyndman M. E. , Eure G. , Ghai S. , Caumartin Y. , Herget E. , Young J. D. , Wiseman D. , Caughlin C. , Gray R. , Wason S. , Mettee L. , Lodde M. , Toi A. , Dujardin T. , Lance R. , Schatz S. M. , Fabrizio M. , Malcolm J. B. , Fradet V. 
Published: November 2020

AbstractObjectivesTo study high‐frequency 29 MHz transrectal side‐fire micro‐ultrasound (micro‐US) for the detection of clinically significant prostate cancer (csPCa) on prostate biopsy, and validate an image interpretation protocol for micro‐US imaging of the prostate.Materials and methodsA prospective randomized clinical trial was performed where 1676 men with indications for prostate biopsy and without known prostate cancer were randomized 1:1 to micro‐US vs conventional end‐fire ultrasound (conv‐US) transrectal‐guided prostate biopsy across five sites in North America. The trial was split into two phases, before and after training on a micro‐US image interpretation protocol that was developed during the trial using data from the pre‐training micro‐US arm. Investigators received a standardized training program mid‐trial, and the post‐training micro‐US data were used to examine the training effect.ResultsDetection of csPCa (the primary outcome) was no better with the first‐generation micro‐US system than with conv‐US in the overall population (34.6% vs 36.6%, respectively, P = .21). Data from the first portion of the trial were, however, used to develop an image interpretation protocol termed PRI‐MUS in order to address the lack of understanding of the appearance of cancer under micro‐US. Micro‐US sensitivity in the post‐training group improved to 60.8% from 24.6% (P < .01), while specificity decreased (from 84.2% to 63.2%). Detection of csPCa in the micro‐US arm increased by 7% after training (32% to 39%, P < .03), but training instituted mid‐trial did not affect the overall results of the comparison between arms.ConclusionMicro‐US provided no clear benefit over conv‐US for the detection of csPCa at biopsy. However, it became evident during the trial that training and increasing experience with this novel technology improved the performance of this first‐generation system.
The diagnostic accuracy of multiparametric MRI for detection and localization of prostate cancer depends on the affected region
Authors: Martins Martina , Regusci Stefano , Rohner Stephane , Szalay‐Quinodoz Ildiko , De Boccard Georges‐Antoine , Strom Louise , Hannink Gerjon , Ramos‐Pascual Sonia , Henry Rochat Charles 
Published: November 2020

AbstractObjectivesTo determine the diagnostic accuracy of 3T multiparametric magnetic resonance imaging (mpMRI) for detecting and locating prostate cancer (PCa) on Dickinson's 27‐sector map, using histopathology specimens from radical prostatectomy (RP) as the reference standard.Patients and methodsThe authors studied a continuous series of 140 patients who underwent RP over three consecutive years. Prior to RP, all patients had mpMRI for detection and localization of PCa and further assessment by biopsy. To minimize the potential of disease progression, 25 patients were excluded because the interval between mpMRI and RP exceeded 6 months, which left 115 patients eligible for analysis. The mpMRI findings were reported using the Prostate Imaging‐Reporting and Data System (PI‐RADS) v2, considering PI‐RADS ≥ 3 to indicate PCa. The histopathology findings from RP specimens were graded using the Gleason scoring system, considering Gleason ≥ 6 to indicate PCa. The location of the tumors was mapped on Dickinson's 27‐sector map for both mpMRI and histopathology and compared by rigid sector‐by‐sector matching.ResultsThe cohort of 115 patients eligible for analysis was aged 66.5 ± 6.0 years at RP. Of the 3105 sectors analyzed, there were 412 true positives (13%), 28 false positives (1%), 68 false negatives (2%), and 2597 true negatives (84%). Across the 27 sectors of the prostate, mpMRI sensitivity ranged from 50% to 100% and specificity from 96% to 100%, while PPV ranged from 50% to 100%, and NPV from 91% to 100%. For the anterior prostate, mpMRI had a sensitivity of 80% (CI, 71%‐86%), specificity of 99% (CI, 99%‐100%), PPV of 91% (CI, 83%‐95%), and NPV of 99% (CI, 98%‐99%). For the posterior prostate, mpMRI had a sensitivity of 88% (CI, 84%‐91%), specificity of 98% (CI, 97%‐99%), PPV of 94% (CI, 92%‐96%), and NPV of 96% (CI, 94%‐97%). Overall, mpMRI had a sensitivity of 86%, specificity of 99%, PPV of 94%, and NPV of 97%.ConclusionsThe accuracy of mpMRI in detecting and locating prostate tumors depends on the affected region, but its high NPV across all sectors suggests that negative findings may not need corroboration by other techniques.
Associations between MTHFR gene polymorphisms and the risk of intracranial hemorrhage: Evidence from a meta‐analysis
Authors: Wang Fenghui , Xu Zhendong , Jiao Haiyan , Wang Aixiang , Jing Youbin 
Published: November 2020

AbstractIntroductionPreviously, a number of genetic epidemiological studies have evaluated associations between MTHFR gene polymorphisms and the risk of intracranial hemorrhage (ICH), with controversial results. Accordingly, we carried out this meta‐analysis to more conclusively evaluate associations between MTHFR gene polymorphisms and the risk of ICH.MethodsMEDLINE, EMBASE, Wanfang, VIP, and CNKI were searched comprehensively, and thirty‐one genetic association studies were finally selected to be included in this meta‐analysis.ResultsEight literatures (963 cases and 2,244 controls) assessed relationship between MTHFR rs1801131 (A1298C) polymorphism and the risk of ICH, and thirty‐one literatures (3,679 cases and 9,067 controls) assessed relationship between MTHFR rs1801133 (C677T) polymorphism and the risk of ICH. We found that AA genotype of rs1801131 polymorphism was significantly associated with a decreased risk of intraventricular hemorrhage (IH) compared with AC/CC genotypes (OR = 0.63; p = .003), AC genotype was significantly associated with an increased risk of IH compared with AA/CC genotypes (OR = 1.55; p = .005), and A allele was significantly associated with a decreased risk of IH compared with C allele (OR = 0.75; p = .02). Additionally, CC genotype of rs1801133 polymorphism was significantly associated with a decreased risk of cerebral hemorrhage (CH) compared with CT/TT genotypes (OR = 0.75; p = .04), TT genotype was significantly associated with an increased risk of CH compared with CC/CT genotypes (OR = 1.27; p = .02), and C allele was significantly associated with a decreased risk of CH compared with T allele (OR = 0.85; p = .007).ConclusionsThis meta‐analysis shows that rs1801131 polymorphism may influence the risk of IH, while rs1801133 polymorphism may influence the risk of CH.
Impact of COVID‐19 pandemic lockdown on narcolepsy type 1 management
Authors: Postiglione Emanuela , Pizza Fabio , Ingravallo Francesca , Vignatelli Luca , Filardi Marco , Mangiaruga Anastasia , Antelmi Elena , Moresco Monica , Oriolo Claudia , Pagotto Uberto , Plazzi Giuseppe 
Published: November 2020

AbstractStudy ObjectivesNarcolepsy type 1 (NT1) is a chronic rare hypersomnia of central origin requiring a combination of behavioral and pharmacological treatments. During the coronavirus disease 2019 (COVID‐19) pandemic, in Italy the population was forced into a lockdown. With this study, we aimed to describe the lockdown impact on NT1 symptom management, according to different patients' working schedule.MethodsIn the period between 10 April and 15 May 2020, we performed routine follow‐up visits by telephone (as recommended during the COVID‐19 emergency) to 50 patients >18 years old (40% males) under stable long‐term treatment. We divided patients into three groups: unchanged working schedule, forced working/studying at home, and those who lost their job (“lost occupation”). Current sleep–wake habit and symptom severity were compared with prelockdown assessment (six months before) in the three patient groups.ResultsAt assessment, 20, 22, and eight patients belonged to the unchanged, working/studying at home, and lost occupation groups, respectively. While in the lost occupation group, there were no significant differences compared with prepandemic assessment, the patients with unchanged schedules reported more nocturnal awakenings, and NT1 patients working/studying at home showed an extension of nocturnal sleep time, more frequent daytime napping, improvement of daytime sleepiness, and a significant increase in their body mass index. Sleep‐related paralysis/hallucinations, automatic behaviors, cataplexy, and disturbed nocturnal sleep did not differ.ConclusionsNarcolepsy type 1 patients working/studying at home intensified behavioral interventions (increased nocturnal sleep time and daytime napping) and ameliorated daytime sleepiness despite presenting with a slight, but significant, increase of weight.
Do firm characteristics affect environmental sustainability? A literature review‐based assessment
Authors: Balasubramanian Sreejith , Shukla Vinaya , Mangla Sachin , Chanchaichujit Janya 
Published: November 2020

AbstractCombating environmental pollution and climate change mandates strong commitment and participation of all firms across sectors. However, the environmental conduct of firms is seen to vary as per their characteristics, especially their size, ownership, and age. Current understanding of these characteristics' influence on environmental sustainability is limited, fragmented, and scattered across the literature, which this study seeks to improve and contribute to. Based on a rigorous screening of the last 25 years' literature (1996–2020), the study develops a comprehensive understanding of firm characteristics' implications for environmental sustainability, namely, environmental practices implementation, environmental drivers, environmental barriers, and associated (environmental, cost/economic, operational, and organizational) performance implications. Several meaningful and generalizable trends, conflicts, and consensus, or lack thereof, are revealed. For instance, the extent of environmental practices' implementation can be seen to be greater at large firms' (vis‐à‐vis small ones) and at foreign firms' (vis‐à‐vis local ones), though not much difference is seen between old and new firms. Also, several metafactors such as resources availability, innovation propensity, and bureaucracy and organizational inertia are identified that explain the differential influence of firm characteristics on environmental sustainability and dispel erroneous stereotypes. Finally, gaps in the literature offering avenues for future research are highlighted along with implications for research, theory, and practice. Results are expected to help policymakers and practitioners develop policies/interventions that ensure all firms, irrespective of their characteristics contribute to environmental sustainability. A comprehensive review of this kind has not been previously undertaken and constitutes the novelty of this work.
Environmental policies and financial performance: stock market reaction to firms for their proactive environmental practices recognized by governmental programs
Authors: Chen Yuan , Singhal Vinod , Zhu Qinghua 
Published: November 2020

AbstractFirms implement proactive environmental practices (PEPs), and governments in developing countries such as China implement environmental policies such as pilot and demonstration programs to promote these PEPs. However, it remains unclear whether and when firms recognized by such governmental programs improve financial performance. Using a sample of 233 firms recognized by a national Chinese government environmental program, event study is employed to estimate stock market reaction of recognized firms. The Heckman two‐stage procedure is followed to examine the moderating effects. We find that the average stock market reaction is not significant. Cross‐sectional analyses indicate that firms with earlier recognitions, recognized for demonstration projects (compared with pilot ones), and operating in more‐polluting industries have greater market reactions, while types of PEPs (internal versus external), export intensity and government ownership (state‐owned or not) do not moderate the market reaction. This paper provides implications for firms about whether and when they should participate in a government environmental program.
Risk of breast cancer in women after a salivary gland carcinoma or pleomorphic adenoma in the Netherlands
Authors: Valstar Matthijs H. , Schaapveld Michael , van den Broek Esther C. , van Velthuysen Marie‐Louise F. , de Ridder Mischa , Schmidt Marjanka K. , van Dijk Boukje A.C. , Balm Alfons J.M. , Smeele Ludi E. 
Published: November 2020

AbstractSalivary and mammary gland tumors show morphological similarities and share various characteristics, including frequent overexpression of hormone receptors and female preponderance. Although this may suggest a common etiology, it remains unclear whether patients with a salivary gland tumor carry an increased risk of breast cancer (BC). Our purpose was to determine the risk of BC in women diagnosed with salivary gland carcinoma (SGC) or pleomorphic adenoma (SGPA). BC incidence (invasive and in situ) was assessed in two nationwide cohorts: one comprising 1567 women diagnosed with SGC and one with 2083 women with SGPA. BC incidence was compared with general population rates using standardized incidence ratio (SIR). BC risk was assessed according to age at SGC/SGPA diagnosis, follow‐up time and (for SGC patients) histological subtype. The mean follow‐up was 7.0 years after SGC and 9.9 after SGPA diagnosis. During follow‐up, 52 patients with SGC and 74 patients with SGPA developed BC. The median time to BC was 6 years after SGC and 7 after SGPA. The cumulative risk at 10 years of follow‐up was 3.1% after SGC and 3.5% after SGPA (95% Confidence Interval (95%CI) 2.1%–4.7% and 2.6%–4.6%, respectively). BC incidence was 1.59 times (95%CI 1.19–2.09) higher in the SGC‐cohort than expected based on incidence rates in the general population. SGPA‐patients showed a 1.48 times (95%CI 1.16–1.86) higher incidence. Women with SGC or SGPA have a slightly increased risk of BC. The magnitude of risk justifies raising awareness, but is no reason for BC screening.