bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coronary slow flow is associated with a worse clinical outcome in patients with Takotsubo syndrome
Authors: Montone Rocco A , Galiuto Leonarda , Meucci Maria Chiara , Del Buono Marco Giuseppe , Vergni Federico , Camilli Massimiliano , Sanna Tommaso , Pedicino Daniela , Buffon Antonino , D'Amario Domenico , Giraldi Luca , Trani Carlo , Liuzzo Giovanna , Rebuzzi Antonio G , Niccoli Giampaolo , Crea Filippo 
Published: January 2020

ObjectivePatients with Takotsubo syndrome (TTS) present an acute microvascular dysfunction that leads to an impaired myocardial perfusion and, in more severe forms, an impaired epicardial flow. However, clinical relevance of a delayed coronary flow, the coronary slow flow (CSF), has never been investigated. We studied the prognostic value of CSF occurring in the acute phase of TTS.MethodsThis cohort study prospectively evaluated patients with a diagnosis of TTS. CSF was defined as angiographically non-obstructive coronary arteries with thrombolysis in myocardial infarction-2 flow. The incidence of overall mortality and major adverse cardiovascular events (MACEs), defined as the composite of TTS recurrence, cardiac rehospitalisation, cerebrovascular events and mortality, was assessed at follow-up.ResultsWe enrolled 101 patients (mean age 71.0±11.1 years, 86 (85.1%) female); CSF occurred in 18 (17.8%) patients. At admission, patients with CSF presented more frequently with Killip class III/IV, moderate-to-severe left ventricle systolic dysfunction and right ventricle dysfunction. During the index admission, patients with CSF had a higher rate of intrahospital complications (12 (66.7%) vs 28 (33.7%), p=0.01). At long-term follow-up, patients with CSF had a significantly higher occurrence of overall mortality (9 (50%) vs 19 (22.9%), p=0.011), mainly due to non-cardiac causes (89.3%), and a higher rate of MACE (10 (55.5%) vs 27 (32.5%), p=0.06). At multivariable Cox regression, CSF was independently associated with death from any causes.ConclusionsPatients with TTS presenting with CSF have a worse clinical presentation with a higher rate of intrahospital complications and a poor long-term clinical outcome.
Disparity in implantable cardioverter defibrillator therapy among minority South Asians in the United Kingdom
Authors: Mistry Amar , Vali Zakariyya , Sidhu Bharat , Budgeon Charley , Yuyun Matthew F , Pooranachandran Vivetha , Li Xin , Newton Michelle , Watts Jamie , Khunti Kamlesh , Samani Nilesh J , Ng G Andre 
Published: January 2020

ObjectiveThere are large geographical differences in implantable cardioverter defibrillator (ICD) implantation rates for reasons not completely understood. In an increasingly multiethnic population, we sought out to investigate whether ethnicity influenced ICD implantation rates.MethodsThis was a retrospective, cohort study of new ICD implantation or upgrade to ICD from January 2006 to February 2019 in recipients of Caucasian or South Asian ethnicity at a single tertiary centre in the UK. Data were obtained from a routinely collected local registry. Crude rates of ICD implantation were calculated for the population of Leicestershire county and were age-standardised to the UK population using the UK National Census of 2011.ResultsThe Leicestershire population was 980 328 at the time of the Census, of which 761 403 (77.7%) were Caucasian and 155 500 (15.9%) were South Asian. Overall, 2650 ICD implantations were performed in Caucasian (91.9%) and South Asian (8.1%) patients. South Asians were less likely than Caucasians to receive an ICD (risk ratio (RR) 0.43, 95% CI 0.37 to 0.49, p<0.001) even when standardised for age (RR 0.75, 95% CI 0.74 to 0.75, p<0.001). This remained the case for primary prevention indication (age-standardised RR 0.91, 95% CI 0.90 to 0.91, p<0.001), while differences in secondary prevention ICD implants were even greater (age-standardised RR 0.49, 95% CI 0.48 to 0.50, p<0.001).ConclusionDespite a universal and free healthcare system, ICD implantation rates were significantly lower in the South Asian than the Caucasian population residing in the UK. Whether this is due to cultural acceptance or an unbalanced consideration is unclear.
Similar progression of carotid intima–media thickness in 7-year surveillance of patients with mild SLE and controls, but this progression is still promoted by dyslipidaemia, lower HDL levels, hypertension, history of lupus nephritis and a higher prednisolone usage in patients
Authors: Ajeganova Sofia , Gustafsson Thomas , Lindberg Linnea , Hafström Ingiäld , Frostegård Johan 
Published: January 2020

ObjectiveTo compare progression of subclinical atherosclerosis and factors promoting it in patients with SLE and controls.MethodsConsecutive patients with SLE and age-matched, sex-matched population controls from the SLEVIC cohort were assessed at inclusion and after 7 years with standardised data collection and carotid ultrasound. Effect of risk factors on carotid intima–media thickness (cIMT) progression was examined with adjusted linear mixed models.ResultsA total of 77 patients and 74 controls, 68% and 61% of the original cohort, completed follow-up. The patients were (mean) 47 years old, 90% were women, and controls were 51 years old, 92% women. Patients had disease duration of (mean) 11 years, mild disease activity and low severity at both assessments. Baseline cIMT did not differ between the groups. An average absolute cIMT progression was 0.009 mm/year in patients and 0.011 mm/year in controls, intergroup difference p=0.9.Of factors at inclusion, dyslipidaemia, lower levels of high-density lipoprotein (HDL) and carotid plaque in patients and controls, and higher systolic blood pressure, total cholesterol:HDL and LDL:HDL ratios and triglycerides in patients were associated with cIMT progression. Of factors at follow-up, hypertension and blood lipids in patients and HDL in controls were significantly associated with cIMT progression. History of lupus nephritis and a higher average dose of prednisolone used since diagnosis were associated with cIMT progression in patients. Associations of risk factors with cIMT progression were stronger in presence of plaques.ConclusionWe observed a statistically comparable progression of cIMT in patients with mild SLE and controls over 7 years, which implies that progression of subclinical atherosclerosis in some patients with SLE could follow that of the general population. Traditional cardiovascular (CV) risk factors, history of lupus nephritis and higher use of corticosteroids promote cIMT progression in SLE. Detection of carotid plaque may add to CV risk stratification.
Fallacies on pairing symmetry and intrinsic electronic Raman spectrum in high-Tc cuprate superconductors
Authors: Kim Hyun-Tak 
Published: January 2020

Certain significant fallacies are involved in discussions of the high-[Formula: see text] mechanism unsolved for over 30 years in cuprate superconductors. These fallacies are explored with the aim of unraveling this mechanism. Moreover, using polarized electronic Raman scattering in inhomogeneous underdoped cuprate superconductors, the intrinsic nonlinear Raman spectrum is obtained by subtracting the pseudogap characteristic of a nonlinear from the linear Raman spectrum measured in the [Formula: see text] mode of the node area below the critical temperature. The intrinsic nonlinear behavior implies the existence of the nodal superconducting gap denying [Formula: see text]-wave pairing symmetry. An origin of the nodal superconducting gap is discussed.
Chapter 7 Småland lithotectonic unit dominated by Paleoproterozoic (1.8 Ga) syn-orogenic magmatism, Svecokarelian orogen
Authors: Wahlgren Carl-Henric , Stephens Michael B. 
Published: January 2020

Abstract

The Småland lithotectonic unit in the 2.0−1.8 Ga Svecokarelian orogen, southeastern Sweden, is dominated by a
c.
1.81−1.77 Ga alkali–calcic magmatic suite (the Transscandinavian Igneous Belt or TIB-1). At least in its central part, the TIB-1 suite was deposited on, or emplaced into,
c.
1.83–1.82 Ga calc-alkaline magmatic rocks with base metal sulphide mineralization and siliciclastic sedimentary rocks (the Oskarshamn–Jönköping Belt). Ductile deformation and metamorphism under low- to medium-grade conditions affected the Oskarshamn–Jönköping Belt prior to
c.
1.81 Ga. Both suites were subsequently affected by low-grade ductile deformation, mainly along steeply dipping, east–west to NW–SE shear zones with dip-slip and dextral strike-slip displacement. Sinistral strike-slip NE–SW zones are also present. In the northern part of the lithotectonic unit, 1.9 Ga magmatic rocks,
c.
1.87–1.81 Ga siliciclastic sedimentary rocks and basalt, and
c.
1.86–1.85 Ga granite show fabric development, folding along steep NW–SE axial surfaces and medium- or high-grade metamorphism prior to
c.
1.81 Ga and, at least partly, at
c.
1.86–1.85 Ga; base metal sulphide, Fe oxide and U or U–REE mineralizations also occur. Magmatism and siliciclastic sedimentation along an active continental margin associated with subduction-related, accretionary tectonic processes is inferred over about 100 million years.
Chapter 9 Continental magmatic arc and siliciclastic sedimentation in the far-field part of a 1.7 Ga accretionary orogen
Authors: Ripa Magnus , Stephens Michael B. 
Published: January 2020

Abstract

Trachyandesitic to trachybasaltic lavas, interlayered siliciclastic sedimentary rocks and subaerial ignimbrites with a rhyolitic to trachydacitic composition lie unconformably above metamorphic rocks in west-central Sweden. These volcanic rocks erupted at 1711 + 7/−6 to 1691 ± 5 Ma and belong to a high-K, calc-alkaline to shoshonitic suite deposited in a continental arc setting. Positive ɛ
Nd
values and Nb/Yb ratios in the trachyandesitic to trachybasaltic rocks indicate an enriched mantle source. Coeval, 1710 ± 11 to 1681 ± 16 Ma plutonic and subvolcanic rocks are mainly granitic or quartz syenitic in composition. Subordinate components include quartz monzonite, quartz monzodiorite and monzogabbro or gabbro. ɛ
Nd
values in the range −1.0 to + 1.1 overlap with those in the inferred 1.9–1.8 Ga source rocks. All these rocks belong to the youngest phase of the lithodemic unit referred to as the Transscandinavian Igneous Belt. This magmatic province extends in a roughly NNW direction for at least 900 km, variably deformed and metamorphosed equivalents occurring inside and beneath younger orogenic belts to the south (Sveconorwegian) and north (Caledonian). The part of the province in west-central Sweden addressed here represents a far-field and shallow crustal component in this 1.7 Ga accretionary orogenic system.
Comparative quantification of primary mitral regurgitation by computer modeling and simulated echocardiography
Authors: Mao Wenbin , Caballero Andrés , Hahn Rebecca T. , Sun Wei 
Published: January 2020

Clinical investigations have demonstrated that mitral regurgitation (MR) quantification using echocardiography (echo) may significantly underestimate or overestimate the regurgitant volume, especially for two-dimensional (2D) echo. Computer modeling and simulated echo were conducted to evaluate the fundamental assumptions in the echo quantification of primary MR that is due to posterior mitral leaflet prolapse. The theoretical flaw of the proximal isovelocity surface area (PISA) method originates from the assumption that the MR flow rate is the product of the isovelocity surface area and aliasing velocity, which is only valid when the velocity vectors are perpendicular to the isovelocity surface. Other factors such as the Doppler angle effect, the view planes of 2D echo, and the single time instant of PISA were also analyzed. We find that the hemielliptic PISA method gives the smallest error for moderate and severe MR cases compared with other PISA methods. Compared with the PISA method, the volumetric technique (VT) is theoretically more robust. By considering correction factors that are caused by nonflat velocity profiles and the closing volume of the aortic valve, the accuracy of the VT method can be significantly improved. The corrected volumetric technique provides more accurate results compared with the PISA methods, especially for mild MR. NEW & NOTEWORTHY We evaluate the accuracy of common echocardiography techniques for the quantification of primary mitral regurgitations using computer modeling. The hemielliptic proximal isovelocity surface area (PISA) method gives the smallest error (within 15%) for moderate and severe mitral regurgitation cases compared with other PISA methods. The volumetric method is theoretically more robust than the PISA method. The accuracy of the volumetric method can be improved by a correction factor around 0.7 because of the nonflat velocity profiles and the closing volume of the aortic valve.
Comparison of hemodynamics, cardiac electrophysiology, and ventricular arrhythmia in an open- and a closed-chest porcine model of acute myocardial infarction
Authors: Lubberding Anniek F. , Sattler Stefan M. , Flethøj Mette , Tfelt-Hansen Jacob , Jespersen Thomas 
Published: January 2020

Ventricular fibrillation (VF) during acute myocardial infarction (AMI) is an important contributor to sudden cardiac death. Large animal models are widely used to study AMI-induced arrhythmia, but the mode of AMI induction ranges from thoracotomy and surgical ligation of a coronary vessel (open chest) to minimally invasive techniques, including balloon occlusion (closed chest). How the choice of induction affects arrhythmia development is unclear. The aim of this study was to compare an open-chest and a closed-chest model with regard to hemodynamics, electrophysiology, and arrhythmia development. Forty-two female Danish Landrace pigs (20 open chest, 22 closed chest) were anesthetized, and occlusion of the mid-left anterior descending coronary artery was performed for 60 min. Opening the chest reduced blood pressure and cardiac output (Δ −22 mmHg, Δ −1.5 L/min from baseline, both P < 0.001 intragroup). Heart rate decreased with opening of the chest but increased with balloon placement ( P < 0.001). AMI-induced ST elevation was lower in the open-chest group ( P < 0.001). Premature ventricular contractions occurred in two distinct phases (0–15 and 15–40 min), the latter of which was delayed in the open-chest group ( P = 0.005). VF occurred in 7 out of 20 and 12 out of 22 pigs in the open-chest and closed-chest groups, respectively ( P = 0.337), with longer time-to-VF in the open-chest group (23.4 ± 1.2 min in open chest and 17.8 ± 1.4 min in closed chest; P = 0.007). In summary, opening the chest altered hemodynamic parameters and delayed the onset of ventricular arrhythmias. Hence, in the search for mechanisms and novel treatments of AMI-induced arrhythmia, caution should be taken when choosing between or comparing the results from these two models. NEW & NOTEWORTHY We demonstrated pronounced differences in hemodynamic parameters and time course of ventricular arrhythmias in regard to mode of infarct induction. Inducing myocardial infarction by thoracotomy and subsequent ligation decreased blood pressure and cardiac output and delayed the onset of ventricular arrhythmia, whereas balloon occlusion resulted in higher heart rates during infarct.
Nitric oxide synthase inhibitors negatively regulate respiration in isolated rodent cardiac and brain mitochondria
Authors: Sakamuri Siva S. V. P. , Sperling Jared A. , Evans Wesley R. , Dholakia Monica H. , Albuck Aaron L. , Sure Venkata N. , Satou Ryousuke , Mostany Ricardo , Katakam Prasad V. G. 
Published: January 2020

Nitric oxide (NO) is known to exert inhibitory control on mitochondrial respiration in the heart and brain. Evidence supports the presence of NO synthase (NOS) in the mitochondria (mtNOS) of cells; however, the functional role of mtNOS in the regulation of mitochondrial respiration is unclear. Our objective was to examine the effect of NOS inhibitors on mitochondrial respiration and protein S-nitrosylation. Freshly isolated cardiac and brain nonsynaptosomal mitochondria were incubated with selective inhibitors of neuronal (nNOS; ARL-17477, 1 µmol/L) or endothelial [eNOS; N5-(1-iminoethyl)-l-ornithine, NIO, 1 µmol/L] NOS isoforms. Mitochondrial respiratory parameters were calculated from the oxygen consumption rates measured using Agilent Seahorse XFe24 analyzer. Expression of NOS isoforms in the mitochondria was confirmed by immunoprecipitation and Western blot analysis. In addition, we determined the protein S-nitrosylation by biotin-switch method followed by immunoblotting. nNOS inhibitor decreased the state IIIu respiration in cardiac mitochondria and both state III and state IIIu respiration in brain mitochondria. In contrast, eNOS inhibitor had no effect on the respiration in the mitochondria from both heart and brain. Interestingly, NOS inhibitors reduced the levels of protein S-nitrosylation only in brain mitochondria, but nNOS and eNOS immunoreactivity was observed in the cardiac and brain mitochondrial lysates. Thus, the effects of NOS inhibitors on S-nitrosylation of mitochondrial proteins and mitochondrial respiration confirm the existence of functionally active NOS isoforms in the mitochondria. Notably, our study presents first evidence of the positive regulation of mitochondrial respiration by mitochondrial nNOS contrary to the current dogma representing the inhibitory role attributed to NOS isoforms. NEW & NOTEWORTHY Existence and the role of nitric oxide synthases in the mitochondria are controversial. We report for the first time that mitochondrial nNOS positively regulates respiration in isolated heart and brain mitochondria, thus challenging the existing dogma that NO is inhibitory to mitochondrial respiration. We have also demonstrated reduced protein S-nitrosylation by NOS inhibition in isolated mitochondria, supporting the presence of functional mitochondrial NOS.
Lactic Acidosis Together with GM-CSF and M-CSF Induces Human Macrophages toward an Inflammatory Protumor Phenotype
Authors: Paolini Léa , Adam Clément , Beauvillain Céline , Preisser Laurence , Blanchard Simon , Pignon Pascale , Seegers Valérie , Chevalier Louise-Marie , Campone Mario , Wernert Romuald , Verrielle Véronique , Raro Pedro , Ifrah Norbert , Lavoué Vincent , Descamps Philippe , Morel Alain , Catros Véronique , Tcherkez Guillaume , Lenaers Guy , Bocca Cinzia , Kouassi Nzoughet Judith , Procaccio Vincent , Delneste Yves , Jeannin Pascale 
Published: January 2020

Abstract

In established tumors, tumor-associated macrophages (TAM) orchestrate nonresolving cancer-related inflammation and produce mediators favoring tumor growth, metastasis, and angiogenesis. However, the factors conferring inflammatory and protumor properties on human macrophages remain largely unknown. Most solid tumors have high lactate content. We therefore analyzed the impact of lactate on human monocyte differentiation. We report that prolonged lactic acidosis induces the differentiation of monocytes into macrophages with a phenotype including protumor and inflammatory characteristics. These cells produce tumor growth factors, inflammatory cytokines, and chemokines as well as low amounts of IL10. These effects of lactate require its metabolism and are associated with hypoxia-inducible factor-1α stabilization. The expression of some lactate-induced genes is dependent on autocrine M-CSF consumption. Finally, TAMs with protumor and inflammatory characteristics (VEGFhigh CXCL8+ IL1β+) are found in solid ovarian tumors. These results show that tumor-derived lactate links the protumor features of TAMs with their inflammatory properties. Treatments that reduce tumor glycolysis or tumor-associated acidosis may help combat cancer.
Temporal Trends in the Practice Pattern for Venous Thromboembolism in Japan: Insight From JROAD‐DPC
Authors: Yamashita Yugo , Morimoto Takeshi , Yoshikawa Yusuke , Yaku Hidenori , Sumita Yoko , Nakai Michikazu , Ono Koh , Kimura Takeshi 
Published: January 2020

Background

Recently, direct oral anticoagulants have been introduced for venous thromboembolism (
VTE
), which might change the management strategies of
VTE
. However, there have been limited data on the current real‐world practice pattern for
VTE
in Asian countries.

Methods and Results

The JROAD‐DPC (Japanese Registry of All Cardiac and Vascular Diseases\xF6Diagnosis Procedure Combination) is a nationwide claim database from 1022 hospitals in Japan between April 2012 and March 2017. We identified 54 369 patients who were hospitalized with a diagnosis of
VTE
at admission based on the
International Classification of Diseases, Tenth Revision
(
ICD‐10
) code. The mean age was 69.1±15.6 years, 59% were women, and mean body mass index was 23.5±5.0 kg/m
2
. The proportion of patients with deep vein thrombosis decreased over time from 72% in 2012 to 38% in 2017. After the release of direct oral anticoagulants, the proportion of patients receiving direct oral anticoagulants increased dramatically among patients with anticoagulation therapy at discharge with the use of edoxaban, rivaroxaban, and apixaban in 35%, 22%, and 27% of patients, respectively, in 2017. On the other hand, the proportion of patients receiving warfarin decreased from 94% in 2012 to 15% in 2017. The median length of a hospital stay decreased over time from 20 days in 2012 to 13 days in 2017 in patients with pulmonary embolism, and from 14 days in 2012 to 12 days in 2017 in patients with deep vein thrombosis. The median cost of hospitalization for pulmonary embolism moderately decreased over time, whereas that for deep vein thrombosis slightly decreased over time.

Conclusions

A nationwide claim‐based database provided the current practice pattern for
VTE
in Japan, which revealed dynamic changes after the release of direct oral anticoagulants.

Clinical Trial Registration

URL
:
www.umin.ac.jp
. Unique identifier:
UMIN
000037868.
Martininema semicordatae n. sp. (Nematoda: Aphelenchoididae) associated with Ficus semicordata in China
Authors: Zhao Xiulan , Zhang Dayuan , Zeng Wensheng , Huang Jianfeng , Zeng Yongsan , Peng Yanqiong , Huang Jianghua , Ye Weimin , Ye Yun , Giblin-Davis Robin M. 
Published: January 2020

Summary
A new nematode species was recovered from the syconia of Ficus semicordata from Xishuangbanna Tropical Botanical Garden, Yunnan Province, China. It is described herein as Martininema semicordatae n. sp. and is characterised by having the combined characters of a long post-vulval uterine sac, excretory pore located at nerve ring level, amoeboid sperm, three pairs of subventral papillae on the male tail, rounded male tail tip with mucron, absence of gubernaculum (= apophysis), and a recurved, rose-thorn-shaped spicule lacking a terminal cucullus. Martininema semicordatae n. sp. differs from other sequenced species by differences in the partial small subunit (SSU) rRNA gene and D2-D3 expansion segments of the large subunit (LSU) rRNA gene. Phylogenetic analysis with LSU D2-D3 expansion segment sequences suggested that M. semicordatae n. sp. is clustered in a highly supported monophyletic clade with M. guangzhouense, M. fistulosus and M. baculum, and shares a common ancestor with these three species.