bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zona incerta neurons projecting to the ventral tegmental area promote action initiation towards feeding
Authors: de Git Kathy C.G. , Hazelhoff Esther M. , Nota Minke H.C. , Schele Erik , Luijendijk Mieneke C.M. , Dickson Suzanne L. , van der Plasse Geoffrey , Adan Roger A.H. 
Published: December 2020

Key points
The zona incerta (ZI) and ventral tegmental area (VTA) are brain areas that are both implicated in feeding behaviour. The ZI projects to the VTA, although it has not yet been investigated whether this projection regulates feeding.
We experimentally (in)activated the ZI to VTA projection by using dual viral vector technology, and studied the effects on feeding microstructure, the willingness to work for food, general activity and body temperature.
Activity of the ZI to VTA projection promotes feeding by facilitating action initiation towards food, as reflected in meal frequency and the willingness to work for food reward, without affecting general activity or directly modulating body temperature.
We show for the first time that activity of the ZI to VTA projection promotes feeding, which improves the understanding of the neurobiology of feeding behaviour and body weight regulation.
AbstractBoth the zona incerta (ZI) and the ventral tegmental area (VTA) have been implicated in feeding behaviour. The ZI provides prominent input to the VTA, although it has not yet been investigated whether this projection regulates feeding. Therefore, we investigated the role of ZI to VTA projection neurons in the regulation of several aspects of feeding behaviour. We determined the effects of (in)activation of ZI to VTA projection neurons on feeding microstructure, food‐motivated behaviour under a progressive ratio schedule of reinforcement, locomotor activity and core body temperature. To activate or inactivate ZI neurons projecting to the VTA, we used a combination of canine adenovirus‐2 in the VTA, as well as Cre‐dependent designer receptors exclusively activated by designer drugs (DREADD) or tetanus toxin (TetTox) light chain in the ZI. TetTox‐mediated inactivation of ZI to VTA projection neurons reduced food‐motivated behaviour and feeding by reducing meal frequency. Conversely, DREADD‐mediated chemogenetic activation of ZI to VTA projection neurons promoted food‐motivated behaviour and feeding. (In)activation of ZI to VTA projection neurons did not affect locomotor activity or directly regulate core body temperature. Taken together, ZI neurons projecting to the VTA exert bidirectional control overfeeding behaviour. More specifically, activity of ZI to VTA projection neurons facilitate action initiation towards feeding, as reflected in both food‐motivated behaviour and meal initiation, without affecting general activity.
Adding Energy Storage to the Combined Cycle
Authors: Conlon William M. , Venetos Milton J. 
Published: December 2020

Abstract
The efficient natural gas Combined Cycle Power Plant (CCPP) has driven a substantial reduction in Greenhouse Gas (GHG) emissions, while gas turbine peaking plants also provide backup for variable renewable resources. As more wind and solar generation is added to grids around the world, there is a need for more flexible CCPPs with faster startup and ramping capability, storage of increasingly over-abundant renewable energy, and lower GHG emissions from dispatchable power plants. Novel integration of energy storage with the CCPP can meet these needs at lower cost than alternatives like batteries.
Inspection of Electronics Components for Cryogenic Temperature Operations
Authors: Poonthottathil N. , Krennrich F. , Weinstein A. , Eisch J. , Bond L. J. , Barnard D. , Zhang Z. , Koester L. 
Published: December 2020

AbstractElectronics operating at cryogenic temperatures play a critical role in future science experiments and space exploration programs. The Deep Underground Neutrino Experiment (DUNE) uses a cold electronics system for data taking. Specifically, it utilizes custom-designed Application Specific Integrated Circuits (ASICs). The main challenge is that these circuits will be immersed in liquid Argon and that they need to function for 20+ years without any access. Ensuring quality is critical, and issues may arise due to thermal stress, packaging, and manufacturing-related defects: if undetected, these could lead to long-term reliability and performance problems. This paper reports an investigation into non-destructive evaluation techniques to assess their potential use in a comprehensive quality control process during prototyping, testing, and commissioning of the DUNE cold electronics system. Scanning acoustic microscopy (SAM) was used to investigate permanent structural changes in the ASICs associated with thermal cycling between room and cryogenic temperatures. Data are assessed using a correlation analysis, which can detect even minimal changes happening inside the ASICs.
On the Macroscopic Response and Field Statistics in Particulate Composites With Elasto-Plastic Phases and Random Microstructures
Authors: Agoras Michalis , Garyfallogiannis Konstantinos , Aravas Nikolaos 
Published: December 2020

Abstract
In this article, we carry out a theoretical investigation of the macroscopic response and field statistics in two-phase particulate composites with elasto-plastic constituents and random microstructures under cyclic loading conditions. To this end, we make use of the “incremental variational homogenization” (IVH) procedure of Agoras et al. (2016, “Incremental Variational Procedure for Elasto-Viscoplastic Composites and Application to Polymer- and Metal-Matrix Composites Reinforced by Spheroidal Elastic Particles,” Int. J. Solid Struct., 97–98, pp. 668–686) and corresponding unit cell finite element simulations. Results are obtained for statistically isotropic distributions of spherical particles and for “spheroidal distributions” of spheroidal particles. It is shown analytically that the IVH estimate of Agoras et al. and that of Lahellec and Suquet (2013, “Effective Response and Field Statistics in Elasto-Plastic and Elasto-Visco-Plastic Composites Under Radial and Non-Radial Loadings,” Int. J. Plasticity, 42, pp. 1–30) are equivalent. In addition, it is illustrated by means of specific numeral comparisons that the IVH estimate is also equivalent (to within numerical accuracy) to the corresponding estimates of Idiart and Lahellec (2016, “Estimates for the Overall Linear Properties of Pointwise Heterogeneous Solids With Application to Elasto-Viscoplasticity,” J. Mech. Phys. Solids, 97, pp. 317–332) and Lucchetta et al. (2019, “A Double Incremental Variational Procedure for Elastoplastic Composites With Combined Isotropic and Linear Kinematic Hardening,” Int. J. Solid Struct., 158, pp. 243–267). Furthermore, it is shown in the context of specific exact results for composite materials with lamellar microstructures that the elastic–plastic coupling and the Bauschinger effect are the macroscopic manifestations of the incompatibility of the local elastic strains. Local strain hardening is incorporate in the IVH model. The predictions of the IVH model for the macroscopic response of particulate composites are found to be in good agreement with the corresponding numerical results, in general. For the extreme cases of rigidly reinforced composites and porous materials, however, the IVH model fails to capture the elastic–plastic coupling and the Bauschinger effect. The underlying reasons for this shortcoming are discussed and a strategy toward the improvement of the IVH model is proposed.
Characterizing strain between rigid crustal blocks in the southern Cascadia forearc: Quaternary faults and folds of the northern Sacramento Valley, California
Authors: Angster Stephen , Wesnousky Steven , Figueiredo Paula , Owen Lewis A. , Sawyer Thomas 
Published: December 2020

AbstractTopographic profiles across late Quaternary surfaces in the northern Sacramento Valley (California, USA) show offset and progressive folding on series of active east- and northeast-trending faults and folds. Optically stimulated luminescence ages on deposits draping a warped late Pleistocene river terrace yielded differential incision rates along the Sacramento River and indicate tectonic uplift equal to 0.2 ± 0.1 and 0.6 ± 0.2 mm/yr above the anticline of the Inks Creek fold system and Red Bluff fault, respectively. Uplift rates correspond to a total of 1.3 ± 0.4 mm/yr of north-directed crustal shortening, accounting for all of the geodetically observed contractional strain in the northern Sacramento Valley, but only part of the far-field contraction between the Sierra Nevada–Great Valley and Oregon Coast blocks. These structures define the southern limit of the transpressional transition between the two blocks.
New geodetic constraints on southern San Andreas fault-slip rates, San Gorgonio Pass, California
Authors: Guns Katherine A. , Bennett Richard A. , Spinler Joshua C. , McGill Sally F. 
Published: December 2020

AbstractAssessing fault-slip rates in diffuse plate boundary systems such as the San Andreas fault in southern California is critical both to characterize seismic hazards and to understand how different fault strands work together to accommodate plate boundary motion. In places such as San Gorgonio Pass, the geometric complexity of numerous fault strands interacting in a small area adds an extra obstacle to understanding the rupture potential and behavior of each individual fault. To better understand partitioning of fault-slip rates in this region, we build a new set of elastic fault-block models that test 16 different model fault geometries for the area. These models build on previous studies by incorporating updated campaign GPS measurements from the San Bernardino Mountains and Eastern Transverse Ranges into a newly calculated GPS velocity field that has been removed of long- and short-term postseismic displacements from 12 past large-magnitude earthquakes to estimate model fault-slip rates. Using this postseismic-reduced GPS velocity field produces a best-fitting model geometry that resolves the long-standing geologic-geodetic slip-rate discrepancy in the Eastern California shear zone when off-fault deformation is taken into account, yielding a summed slip rate of 7.2 ± 2.8 mm/yr. Our models indicate that two active strands of the San Andreas system in San Gorgonio Pass are needed to produce sufficiently low geodetic dextral slip rates to match geologic observations. Lastly, results suggest that postseismic deformation may have more of a role to play in affecting the loading of faults in southern California than previously thought.
Two-year follow up of a cluster randomised controlled trial for women experiencing intimate partner violence: effect of screening and family doctor-delivered counselling on quality of life, mental and physical health and abuse exposure
Authors: Hegarty Kelsey , Valpied Jodie , Taft Angela , Brown Stephanie Janne , Gold Lisa , Gunn Jane , O'Doherty Lorna 
Published: December 2020

ObjectivesThis was a 2-year follow-up study of a primary care-based counselling intervention (weave) for women experiencing intimate partner violence (IPV). We aimed to assess whether differences in depression found at 12 months (lower depression for intervention than control participants) would be sustained at 24 months and differences in quality in life, general mental and physical health and IPV would emerge.DesignCluster randomised controlled trial. Researchers blinded to allocation. Unit of randomisation: family doctors.SettingFifty-two primary care clinics, Victoria, Australia.ParticipantsBaseline: 272 English-speaking, female patients (intervention n=137, doctors=35; control n=135, doctors=37), who screened positive for fear of partner in past 12 months. Twenty-four-month response rates: intervention 59% (81/137), control 63% (85/135).InterventionsIntervention doctors received training to deliver brief, woman-centred counselling. Intervention patients were invited to receive this counselling (uptake rate: 49%). Control doctors received standard IPV information; delivered usual care.Primary and secondary outcome measuresTwenty-four months primary outcomes: WHO Quality of Life-Bref dimensions, Short-Form Health Survey (SF-12) mental health. Secondary outcomes: SF-12 physical health and caseness for depression and anxiety (Hospital Anxiety Depression Scale), post-traumatic stress disorder (Check List-Civilian), IPV (Composite Abuse Scale), physical symptoms (≥6 in last month). Data collected through postal survey. Mixed-effects regressions adjusted for location (rural/urban) and clustering.ResultsNo differences detected between groups on quality of life (physical: 1.5, 95% CI −2.9 to 5.9; psychological: −0.2, 95% CI −4.8 to 4.4,; social: −1.4, 95% CI −8.2 to 5.4; environmental: −0.8, 95% CI −4.0 to 2.5), mental health status (−1.6, 95% CI −5.3 to 2.1) or secondary outcomes. Both groups improved on primary outcomes, IPV, anxiety.ConclusionsIntervention was no more effective than usual care in improving 2-year quality of life, mental and physical health and IPV, despite differences in depression at 12 months. Future refinement and testing of type, duration and intensity of primary care IPV interventions is needed.Trial registration numberACTRN12608000032358.
Safety and feasibility evaluation of planning and execution of surgical revascularisation solely based on coronary CTA and FFRCT in patients with complex coronary artery disease: study protocol of the FASTTRACK CABG study
Authors: Kawashima Hideyuki , Pompilio Giulio , Andreini Daniele , Bartorelli Antonio L , Mushtaq Saima , Ferrari Enrico , Maisano Francesco , Buechel Ronny R , Tanaka Kaoru , La Meir Mark , De Mey Johan , Schneider Ulrich , Doenst Torsten , Teichgräber Ulf , Stone Gregg W , Sharif Faisal , de Winter Robbert , Thomsen Brian , Taylor Charles , Rogers Campbell , Leipsic Jonathon , Wijns William , Onuma Yoshinobu , Serruys Patrick W 
Published: December 2020

IntroductionThe previously published SYNTAX III REVOLUTION trial demonstrated that clinical decision-making between coronary artery bypass graft (CABG) and percutaneous coronary intervention based on coronary CT angiography (CCTA) had a very high agreement with the treatment decision derived from invasive coronary angiography (ICA). The study objective of the FASTTRACK CABG is to assess the feasibility of CCTA and fractional flow reserve derived from CTA (FFRCT) to replace ICA as a surgical guidance method for planning and execution of CABG in patients with three-vessel disease with or without left main disease.Methods and analysisThe FASTTRACK CABG is an investigator-initiated single-arm, multicentre, prospective, proof-of-concept and first-in-man study with feasibility and safety analysis. Surgical revascularisation strategy and treatment planning will be solely based on CCTA and FFRCT without knowledge of the anatomy defined by ICA. Clinical follow-up visit including CCTA will be performed 30 days after CABG in order to assess graft patency and adequacy of the revascularisation with respect to the surgical planning based on non-invasive imaging (CCTA) with functional assessment (FFRCT) and compared with ICA. Primary feasibility endpoint is CABG planning and execution solely based on CCTA and FFRCT in 114 patients. Primary safety endpoint based on 30 day CCTA is graft assessment and topographical adequacy of the revascularisation procedure. Automatic non-invasive assessment of functional coronary anatomy complexity is also evaluated with FFRCT for functional Synergy Between percutaneous coronary intervention With Taxus and Cardiac Surgery Score assessment on CCTA. CCTA with FFRCT might provide better anatomical and functional analysis of the coronary circulation leading to appropriate anatomical and functional revascularisation, and thereby contributing to a better outcome.Ethics and disseminationEach patient has to provide written informed consent as approved by the ethical committee of the respective clinical site. Results will be submitted for publication in peer-reviewed journals and will be disseminated at scientific conferences.Trial registration numberNCT04142021.
Protocol for an implementation and realist evaluation of a new organisational model for primary care practices in the canton of Vaud, Switzerland
Authors: Schutz Leuthold Muriel , Schwarz Joelle , Marti Joachim , Perraudin Clémence , Hudon Catherine , Peytremann-Bridevaux Isabelle , Senn Nicolas , Cohidon Christine 
Published: December 2020

IntroductionContinuity of care, especially for patients with complex needs, is a major challenge for healthcare systems in many high-income countries, including Switzerland. Since 2015, a collaborative project between Unisanté-Department of Family Medicine (DMF), some general practitioners (GPs) and canton of Vaud’s public health authorities has sought to develop a new organisational model for the provision of primary care to ensure better care coordination and to provide adapted care deliveries to patients’ healthcare needs. The model’s main component is the addition of a primary care nurse to GPs practices. Three additional tools are individualised patient care plans, electronic medical records and patient empanelment. To assess this model, a 2-year pilot study has begun in nine GPs’ practices in the canton. This paper presents the protocol for an evaluation of the implementation and effectiveness of the new organisational model.Method and analysisWe will conduct a before-and-after study using a mixed-methods and a realist approach. First, we will use quantitative and qualitative data to assess the new organisational model’s implementation (feasibility, fidelity, acceptability and costs) and effectiveness (healthcare services use, patient experience, staff experience and patient-level costs). Combining this data with focus group data will enable a realist evaluation of the pilot project, which will help understand the elements of context and mechanism that affect implementation.Ethics and disseminationThe evaluation will inform the canton of Vaud’s health authorities about the limits of and perspectives for this organisational model. All results will also be made available to the practices and the patients involved. At the end of the project, we will propose organisational adaptations and a sustainable financial model for extending the model to other practices in the canton and potentially to the national level.The canton of Vaud’s Human Research Ethics Committee approved the study, and Data Protection and Information Law Authority gave a favourable opinion concerning data processing procedures.
Quality appraisal of clinical guidelines for venous thromboembolism prophylaxis in patients undergoing hip and knee arthroplasty: a systematic review
Authors: Wang Yu , Zhu Li-Yun , Deng Hai-Bo , Yang Xu , Wang Lei , Xu Yuan , Wang Xiao-Jie , Pang Dong , Sun Jian-Hua , Cao Jing , Liu Ge , Liu Ying , Ma Yu-Fen , Wu Xin-Juan 
Published: December 2020

IntroductionVenous thromboembolism (VTE) occurs in up to 40%–80% of patients after hip and knee arthroplasty. Clinical decision-making aided by guidelines is the most effective strategy to reduce the burden of VTE. However, the quality of guidelines is dependent on the strength of their evidence base. The objective of this article is to critically evaluate the quality of VTE prevention guidelines and the strength of their recommendations in VTE prophylaxis in patients undergoing hip and knee arthroplasty.MethodsRelevant literature up to 16 March 2020 was systematically searched. We searched databases such as Web of Science, PubMed, EMBASE, Cumulative Index of Nursing and Allied Health Literature, China National Knowledge Infrastructure and WanFang and nine guidelines repositories. The identified guidelines were appraised by two reviewers using the Appraisal of Guidelines for Research and Evaluation II and appraised the strength of their recommendations independently. Following quality assessment, a predesigned data collection form was used to extract the characteristics of the included guideline.ResultsWe finally included 15 guidelines. Ten of the included guidelines were rated as ‘recommended’ or ‘recommended with modifications’. The standardised scores were relatively high in the domains of Clarity of Presentation, and Scope and Purpose. The lowest average standardised scores were observed in the domains of Applicability and Stakeholder Involvement. In reference to the domains of Rigour of Development and Editorial Independence, the standardised scores varied greatly between the guidelines. The agreement between the two appraisers is almost perfect (intraclass correlation coefficients higher than 0.80). A considerable proportion of the recommendations is based on low-quality or very-low-quality evidence or is even based on working group expert opinion.ConclusionsIn summary, the majority of the recommendations are based on low-quality evidence, and further confirmation is needed. Furthermore, guideline developers should pay more attention to methodological quality, especially in the Stakeholder Involvement domain and the Applicability domain.
Early detection of COVID-19 in China and the USA: summary of the implementation of a digital decision-support and disease surveillance tool
Authors: Hswen Yulin , Brownstein John S , Xu Xiang , Yom-Tov Elad 
Published: December 2020

ObjectivesRapid detection and surveillance of COVID-19 is essential to reducing spread of the virus. Inadequate screening capacity has hampered COVID-19 detection, while traditional infectious disease response has been delayed due to significant demands for healthcare resources, time and personnel. This study investigated whether an online health decision-support tool could supplement COVID-19 surveillance and detection in China and the USA.SettingDaily website traffic to Thermia was collected from China and the USA, and cross-correlation analyses were used to assess the designated lag time between the daily time series of Thermia sessions and COVID-19 case counts from 22 January to 23 April 2020.ParticipantsThermia is a validated health decision-support tool that was modified to include content aimed at educating users about Centers for Disease Control and Prevention recommendations on COVID-19 symptoms. An advertising campaign was released on Microsoft Advertising to refer searches for COVID-19 symptoms to Thermia.ResultsThe lead times observed for Thermia sessions to COVID-19 case reports was 3 days in China and 19 days in the USA. We found negative cross-correlation between the number of Thermia sessions and rates of influenza A and B, possibly due to the decreasing prevalence of influenza and the lack of specificity of the system for identification of COVID-19.ConclusionThis study suggests that early deployment of an online campaign and modified health decision-support tool may support identification of emerging infectious diseases like COVID-19. Researchers and public health officials should deploy web campaigns as early as possible in an epidemic to detect, identify and engage those potentially at risk to help prevent transmission of the disease.