bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of DAXX and ATRX expression on telomere length and prognosis of breast cancer patients
Authors: Hussien Marwa T. , Shaban Shimaa , Temerik Doaa F. , Helal Shaaban R. , Mosad Eman , Elgammal Sahar , Mostafa Abeer , Hassan Eman , Ibrahim Abeer 
Published: August 2020

Abstract
Background
Telomere stability is one of the hallmarks of cancer that promotes cellular longevity, the accumulation of genetic alterations, and tumorigenesis. The loss of death domain-associated protein (DAXX) and α-thalassemia/mental retardation X-linked protein (ATRX) plays a role in telomere lengthening and stability. This study aims to evaluate the prognostic significance of telomere length (TL) and its association with DAXX and ATRX proteins in breast cancer (BC). Our study used the FISH technique to detect peptide nucleic acid (PNA) in the peripheral blood cells of a cohort of BC patients (n = 220) and a control group of apparently healthy individuals (n = 100). Expression of DAXX and ATRX proteins was evaluated using immunohistochemistry (IHC) in all BC tissues.

Results
Patients with a shorter TL had worse disease-free survival (DFS) and overall survival (OS). There were significant associations between shorter TL and advanced disease stages, lymph node metastasis, and positive HER2/neu expression. DAXX protein expression was significantly correlated with TL. Lower DAXX expression was significantly with shorter DFS.

Conclusion
Assessing TL can be used as a worthy prognostic indicator in BC patients. Specifically, short TL had a poor impact on the prognosis of BC patients. Low DAXX expression is associated with poor outcomes in BC. Further mechanistic studies are warranted to reveal the underlying mechanisms of these associations.
Sonopartogram versus conventional partogram for monitoring progress of labor: a prospective observational study
Authors: Sweed Mohamed S. , Allam Ihab F. , Ashoush Sherif A. , Marwan Osama A. , NasrElDin Eman A. 
Published: August 2020

Abstract
Background
Repeated digital vaginal examination during labor may be uncomfortable for women and increases the risk of ascending infection. Transperineal ultrasound can assess fetal head descent, position, and cervical dilatation without these side effects. This study was conducted to evaluate the accuracy of transperineal ultrasound in monitoring labor progress.

Results
The study included 40 primigravida women in labor. Fair correlation was found between the assessment of fetal head station by vaginal examination (VE) and fetal head perineal distance (HPD) by transperineal ultrasound (TPUS) (Kendall’s tau-b (τ) = − 0.299, 95% CI = − 0.479 to − 0.0863, p value = .0063) (Spearman rho = − .3844, p value = .0143; r2 = 0.1478). Strong correlation was found between the cervical dilatation assessed by VE and by TPUS (Pearson’s r = .8601, 95% CI = 0.7493 to 0.9240, p value < .0001, r2 = 0.7396). There is moderate agreement between VE and TPUS as regards the assessment of head position on the face-clock [weighted kappa (κ) = .557, 95% CI = .362 to.753].

Conclusion
Transperineal ultrasound can be used as an alternative to repeated digital examination for assessment of labor progress.
COVID-19–Related Ethics Consultations at a Cancer Center in New York City: A Content Review of Ethics Consultations During the Early Stages of the Pandemic
Authors: Friedman Danielle Novetsky , Blackler Liz , Alici Yesne , Scharf Amy E. , Chin Martin , Chawla Sanjay , James Monique C. , Voigt Louis P. 
Published: August 2020

PURPOSE:The coronavirus disease 2019 (COVID-19) pandemic has raised a variety of ethical dilemmas for health care providers. Limited data are available on how a patient’s concomitant cancer diagnosis affected ethical concerns raised during the early stages of the pandemic.METHODS:We performed a retrospective review of all COVID-related ethics consultations registered in a prospectively collected ethics database at a tertiary cancer center between March 14, 2020, and April 28, 2020. Primary and secondary ethical issues, as well as important contextual factors, were identified.RESULTS:Twenty-six clinical ethics consultations were performed on 24 patients with cancer (58.3% male; median age, 65.5 years). The most common primary ethical issues were code status (n = 11), obligation to provide nonbeneficial treatment (n = 3), patient autonomy (n = 3), resource allocation (n = 3), and delivery of care wherein the risk to staff might outweigh the potential benefit to the patient (n = 3). An additional nine consultations raised concerns about staff safety in the context of likely nonbeneficial treatment as a secondary issue. Unique contextual issues identified included concerns about public safety for patients requesting discharge against medical advice (n = 3) and difficulties around decision making, especially with regard to code status because of an inability to reach surrogates (n = 3).CONCLUSION:During the early pandemic, the care of patients with cancer and COVID-19 spurred a number of ethics consultations, which were largely focused on code status. Most cases also raised concerns about staff safety in the context of limited benefit to patients, a highly unusual scenario at our institution that may have been triggered by critical supply shortages.
A New Therapeutic Approach Using a Calcilytic (AXT914) for Postsurgical Hypoparathyroidism in Female Rats
Authors: Lim Yun-Sung , You Byung Hoon , Kim Hee-Bok , Lim So Hyun , Song Jae Geun , Bae Min Goo , Han Hyo-Kyung , Choi Young Hee , Choi Han Seok 
Published: August 2020

Abstract
Postsurgical hypoparathyroidism is the most common complication of thyroid surgery. Conventional therapy with high-dose calcium and vitamin D can correct hypocalcemia but can increase the risk of hypercalciuria, renal stones, or ectopic calcification. The aim of the present study was to investigate the efficacy of a calcium-sensing receptor antagonist, also called a calcilytic (AXT914), in rat models of postsurgical hypoparathyroidism. Two postsurgical hypoparathyroidism rat models were made by hemi-parathyroidectomy or total parathyroidectomy with autotransplantation in 10-week-old female Wistar rats. AXT914 or vehicle was administered orally for 2 to 3 weeks. Serum PTH, calcium, and phosphorus levels, and the urinary excretion of calcium were measured. Autotransplanted parathyroid tissues were collected and examined histologically. In the hemi-parathyroidectomy model, the oral administration of the calcilytic AXT914 (5 and 10 mg/kg) for 2 weeks increased serum PTH and calcium levels and decreased serum phosphorus levels and urinary calcium excretion. In the total parathyroidectomy with autotransplantation model, the oral administration of AXT914 (10 mg/kg) for 3 weeks increased serum PTH and calcium levels and decreased serum phosphorus levels. The serum PTH and calcium levels increased by AXT914 were maintained for 1 week, even after discontinuation of the drug. In conclusion, AXT914 increased PTH secretion in rat models of postsurgical hypoparathyroidism, thereby correcting abnormal calcium and phosphorus homeostasis. Furthermore, AXT914 improved the functional recovery of autotransplanted parathyroid tissues.
Sex-dependent effect of APOE on Alzheimer's disease and other age-related neurodegenerative disorders
Authors: Gamache Julia , Yun Young , Chiba-Falek Ornit 
Published: August 2020

ABSTRACT
The importance of apolipoprotein E (APOE) in late-onset Alzheimer's disease (LOAD) has been firmly established, but the mechanisms through which it exerts its pathogenic effects remain elusive. In addition, the sex-dependent effects of APOE on LOAD risk and endophenotypes have yet to be explained. In this Review, we revisit the different aspects of APOE involvement in neurodegeneration and neurological diseases, with particular attention to sex differences in the contribution of APOE to LOAD susceptibility. We discuss the role of APOE in a broader range of age-related neurodegenerative diseases, and summarize the biological factors linking APOE to sex hormones, drawing on supportive findings from rodent models to identify major mechanistic themes underlying the exacerbation of LOAD-associated neurodegeneration and pathology in the female brain. Additionally, we list sex-by-genotype interactions identified across neurodegenerative diseases, proposing APOE variants as a shared etiology for sex differences in the manifestation of these diseases. Finally, we present recent advancements in ‘omics’ technologies, which provide a new platform for more in-depth investigations of how dysregulation of this gene affects the development and progression of neurodegenerative diseases. Collectively, the evidence summarized in this Review highlights the interplay between APOE and sex as a key factor in the etiology of LOAD and other age-related neurodegenerative diseases. We emphasize the importance of careful examination of sex as a contributing factor in studying the underpinning genetics of neurodegenerative diseases in general, but particularly for LOAD.
Üks laenuline perekonnanime tüüp: nimed lõpuga -mees
Authors: Kallasmaa Marja , Puss Fred 
Published: August 2020

Kirjutises esitletakse Eesti perekonnanimede tüüpi, kus nime lõpuosiseks on -mees. Perekonnanimede panekul 1822–1835 on nimesid lõpuga -mees (-mes) pandud rohkem kui 140 mõisas. Paljud neist on hääbunud, samas on seda tüüpi perekonnanimesid pandud/võetud ka XX sajandil: 1921–1922 Petserimaal ja Narvatagusel ning 1935–1940 nimede eestistamisel. Kirjutises on ära toodud kõik 63 mees-lõpulist perekonnanime, mis esinesid rahvastikuregistris aastal 2017, nimekandjate hulk sel aastal, nimede päritolu ja tekkekoht, enamasti mõisa täpsusega. Nenditakse, et nimetüüp lõpuga -mees on laen saksa keelest (tõlgitud on saksa perekonnanimede formant -mann ’mees, inimene’), ehkki vastavaid eeskujuks olevaid liitsõnu esineb ka eesti keeles (näiteks aumees, jahimees, kälimees, maamees, põllumees, sannamees, talumees, nimepanemise ajal arvatavasti juba ka laenuline kaupmees). Saksa keelest on enamasti siiski laenatud nii perekonnanimede struktuuritüüp kui ka sageli nimeosade leksika (mugand, laen või otsetõlge eesti keelde). Vaid iga kümnenda nime puhul võiks väita, et aluseks on eestikeelne liitsõna. Huvitaval kombel järgib mees-lõpuline perekonnanimetüüp levikuala, mis on kindlaks tehtud paljude murdenähtuste puhul.
Abstract. Marja Kallasmaa and Fred Puss: A borrowed name type: surnames ending with ‑mees ‘man’. In the Population Register in 2017, there were 63 surnames ending with -mees ‘man’. The article presents the etymology of all these names. The Estonian surname type ending -mees has mostly been borrowed from German surnames with the name formant -mann. Estonian peasants received their surnames in the 19th century (about 31,000 surnames in 1822–1835, of those around 100 ending with -mees). Among those, there were around 5,020 occasions of surnames (around 2,000 different names) ending with -man(n), mostly in North Estonia. In 1935–1940, the peak of the Estonianization of surnames took place and 22 names ending with -mees were added. 1. Most of surnames ending with -mees are translation loans as Jõemees (Bachmann), Majamees (Hausmann), Metsmees (Waldmann), Mäemees (Bergmann), Nõmmemees (Heidemann), etc. In one surname, a partial translation of the first part has been found: Piirimees (Altegrenzmann). 2. Surnames with adapted first part: Valdmees (Waldmann), Kunstimees (Kunstmann). 3. There are different first parts of surnames in the islands of Hiiumaa and Saaremaa: in Hiiumaa, the first parts are toponyms, in Saaremaa, mostly adjectives. 4. Some surnames present the dialectal form versus standard language form: Mõtsmees and Metsmees (dialectal mõts, standard mets ‘forest’), Tepomees and Teppomees (standard male name Tepo, in the coastal dialect Teppo, same in the old spelling), Sannamees (standard saunamees ‘smallholder’). The surname written in 1835 – Maelzemees – has given three different present-day spellings: Mäeltsemees, Mältsamees and Määltsemees. 5. German influence is both structural and lexical (translation, adaptation, word selection). 6. Only around one tenth of the names come from Estonian compound words.
„Meil oli Mihkel Mehka ja ta naise nimi Hipp“ – Hargla kihelkonna tunnuslikest eesnimedest
Authors: Pae Taavi 
Published: August 2020

Siinses artiklis vaatlen Hargla kihelkonna isikunimistut, keskendudes piirkonna tunnusnimedele Mehka ja Hipp. Neist esimese järgi on tekkinud piirkonnanimi Mehkamaa ja ka etnonüüm mehkad piirkonna elanike tähistamiseks. Nimekasutuse uurimiseks koostasin Eesti Rahvusarhiivis säilitatavate Hargla kihelkonna kirikuraamatute põhjal eesnimekorpuse. Eelkõige analüüsin tunnusnimede ajalist ulatust lähtuvalt legendist, mille järgi Põhjasõja aegadel jäid piirkonda elama vaid Mehka ja Hipp ning Mõniste ümbruse rahvas pärineb suuresti sellest kooselust. Arhiiviallikad näitavad, et nimi Mehka ilmub kirikuraamatutesse alles 18. sajandi lõpus, kuid nimi võis olla varem kirikuraamatusse kirjutatud Mihklina. Eelmainitud legendi võib aga pidada kunstlikuks, mille levik on seotud eelkõige Mõniste muuseumiga, kus seda hakati tutvustama. Hargla kihelkonna üldine nimevaramu muutus aga käib kokku ühiskondlike muutustega 19. sajandi lõpukümnenditel ja sealt kadusid koos mitmete teiste toonaste tavaliste nimedega ka piirkonna tunnuseesnimed Mehka ja Hipp.
Abstract. Taavi Pae: “We used Mehka instead Mihkel and his wife’s name was Hipp” – On the characteristic first names of Hargla parish. In this article, I analyse first names in the Hargla parish (Võru county in Southern Estonia), focusing on two historically typical first names for the region: Mehka and Hipp. The first of these has been used to identify the whole area (Mehkamaa) as well as an ethnonym (mehkad). The author compiled a firstname corpus based on the Hargla parish register kept in the Estonian National Archives. One motive for the analysis was to verify the folklore of only two people in the area – a Mehka and a Hipp – surviving the Great Northern War, with the full population of the area descending from this partnership. The archive materials indicate that Mehka appeared in the parish register only in the late 18th century. There are several references to the earlier use of that name, but in the parish record they were marked as Mihkel. Nonetheless, the ‘folklore’ can be considered artificial with its spread primarily related to the Mõniste Museum founded in 1957. The general change in the name system of Hargla parish coincided with the social changes in the late 19th century. The regional first names Mehka and Hipp disappeared and the names became longer and more German-like.
A 45-year follow-up study of adolescent schizophrenia. Part I: Premorbid values of psychological and relational indicators in the context of illness course and long-term social functioning of patients
Authors: Ślosarczyk Mariusz , Ślosarczyk Katarzyna , Furgał Mariusz 
Published: August 2020

Cel pracyW literaturze przedmiotu rzadko spotyka się badania nad predyktorami przebiegu schizofrenii młodzieńczej, zwłaszcza oparte na danych pochodzących z długoterminowych katamnez. W naszej analizie badamy zależności pomiędzy przedchorobowym funkcjonowaniem badanych a wskaźnikami klinicznymi i społecznymi przebiegu choroby.Metoda69 pacjentów hospitalizowanych w wieku średnio 16 lat (punkt 0) z powodu schizofrenii (rediagnozowanej retrospektywnie wg kryteriów ICD-10) i powtórnie zbadanych w 5 lat później (punkt 1 – badanie osobiste dotyczyło 41 osób) zostało po raz kolejny poddanych ocenie pod kątem parametrów klinicznych i społecznych w 45 lat po wyjściowej hospitalizacji (punkt 2 – badanie osobiste dotyczyło 21 osób).WynikiPrzedchorobowe wskaźniki nastroju, napędu życiowego, ekspresji uczuć, poziomu wycofania społecznego, inteligencji, lęku, rozwoju popędowości seksualnej i agresywnej oraz rodzinnego i pozarodzinnego życia relacyjnego ujawniły liczne i różnorodne korelacje zarówno z obrazem objawowym i klinicznym przebiegiem schizofrenii, jak i odległym funkcjonowaniem społecznym badanych. Zmiennymi o największym znaczeniu rokowniczym okazały się być: postawa uczuciowa „od” ludzi i świata oraz bogate życie relacyjne poza rodziną pochodzenia. Zmienne te ujawniły przeciwstawne korelacje zwłaszcza z nasileniem objawów negatywnych, poziomem późnego wglądu i regresji, jakością życia zawodowego i punktacją w skali GAF, przy czym korelacje bogatego życia relacyjnego należy ocenić jako pozytywne, a korelacje postawy „od” jako negatywne. Istotny okazał się również harmonijny rozwój popędowości oraz wysoka inteligencja. Korelacje obu tych zmiennych okazały się korzystne zarówno w wymiarze klinicznym, jak i społecznymWnioskiTak zwana osobowość przedchorobowa opisywana przez szereg wskaźników okazuje się być istotnym czynnikiem prognostycznym w schizofrenii młodzieńczej.
Neologismos em áreas de especialidade
Authors: Oliveira Elvirley Freires Rodrigues de , Minussi Rafael Dias 
Published: August 2020

Os neologismos têm uma forte ligação com a inovação e a criatividade. Os mecanismos de criação e inovação permitem o surgimento de novos vocábulos e não raro este fenômeno surge primeiramente em áreas de especialidade para então passar a fazer parte do vocabulário comum, embora o contrário também ocorra. Este artigo busca descrever a produtividade neológica e, para isso, lançamos mão da análise semiautomática de um corpus de pesquisa, a fim de realizar uma descrição, classificação e quantificação da neologia (neologismo, estrangeirismo e empréstimo linguístico) em relação às áreas de especialidade, tomando como base no corpus de pesquisa composto por revistas voltadas para o público feminino. Como resultado da pequisa, destacamos que o fenômeno linguístico mais produtivo em termos absolutos na amostra estudada foi o estrangeirismo com 58% do total. Por sua vez, encontramos um número reduzido de empréstimos linguísticos, perfazendo 4% do total da amostra.
Apresentação do dicionário multilíngue de termos do setor feirístico
Authors: Godoy Ariane Dutra Fante 
Published: August 2020

O setor feirístico tem grande relevância no cenário econômico nacional e internacional, pois fomenta o intercâmbio de contatos comerciais e novos negócios e está em constante expansão. Ainda que seja uma área forte no Brasil e no mundo, não se encontram disponíveis no mercado materiais terminográficos para os profissionais envolvidos nesse setor (expositores, empresas organizadoras de feiras, promotoras, visitantes, intérpretes e tradutores). Para preencher essa lacuna, considerando a importância da participação em feiras de negócios para o crescimento da economia interna e a expansão das exportações, o objetivo geral deste trabalho é identificar a terminologia multilíngue do domínio das feiras com o objetivo específico de elaborar um dicionário terminológico unidirecional do português para o inglês, o francês e o italiano de termos desse setor. Para tanto, baseamo-nos nos conceitos da Teoria Comunicativa da Terminologia (CABRÉ, 1993, 1999), Equivalência Terminológica (DUBUC, 1985, 1992), Variação Terminológica (FAULSTICH, 1998, 2001) e Linguística de Corpus (BERBER SARDINHA, 2004); reunimos corpora de estudo nas 4 línguas (guias e manuais do expositor); fizemos o levantamento dos candidatos a termo com o auxílio da WordSmith tools (MIKE SCOTT, 2012), elencando-os em fichas terminológicas criadas por meio da ferramenta SDL MultiTerm (2017). Os 311 termos estudados em cada língua foram analisados em seus contextos de uso e os ganchos terminológicos levantados para o estabelecimento das equivalências. Para este artigo, apresentamos as etapas metodológicas, o método de estabelecimento de equivalências, a macro e microestrutura e modelos de verbetes e informações numéricas acerca do dicionário.
Chemotranscriptome analysis indicates the neurotrophic and neuromodulator effects of a citicoline molecule
Authors: Torshin I. Yu. , Gromova O. A. , Stakhovskaya L. V. , Semenov V. A. , Shchukin I. A. 
Published: August 2020

Objective: to investigate the effect of citicoline (CTC) on gene transcription.Material and methods. Chemotranscriptome analysis of the CTC molecule was carried out on an NPC.TAK model, provided that the cells were incubated with CTC for 24 hours.Results and discussion. CTC dose-dependently affected the transcription of 8,838 out of 12,716 annotated human genes, mainly by increasing the transcription of the genes involved: 1) in the neurotransmitter metabolism of serotonin (n=36), dopamine (n=32), GABA (n=14), and acetylcholine (n=27); 2) in showing the effects of neurotrophic factors (n=152), including nerve growth factor (n=11); 3) in maintaining the cardiovascular system (vasodilation and cardiac electrical activity; a total of 76 genes). CTC reduced the transcription of the genes, whose protein activity supported inflammation (n=86) and cell division (n=656). CTC elevated the expression of 60 genes involved in triglyceride processing and decreased the expression of 51 genes whose proteins were involved in cholesterol metabolism. CTC increased the transcription of the genes involved in the body’s response to various drugs, including antiepileptic drugs (n=20), dopaminergic agents (n=19), antipsychotics (n=38), anxiolytics (n=21), sedatives (n=22), antidepressants (n=35), anesthetics (n=23), and antidementia drugs (n=11).Conclusion. Chemotranscriptome analysis indicated the positive effect of CTC on neurotransmission, neuroprotection, lipid profile, and a higher neuronal susceptibility to other neuroactive drugs.
The Aesthetic Taste Representation of Coastal Community
Authors: Wiyoso Joko , Putra Bintang Hanggoro 
Published: August 2020

Aesthetic tastes of a person to an art form are determined by the knowledge and experience that comes from the culture of the community. In this regard, this study aims to determine the aesthetic tastes of coastal communities as reflected in the collaborative packaging of the traditional art of Barong Ngesti Wargo Budoyo. The method used was a qualitative research method with data collection techniques, observation, interviews and documentation, then the data were analyzed based on interactive data analysis which the flow were data reduction, data presentation, drawing conclusions and verification. The results showed that the collaborative packaging of the traditional art of Barong Ngesti Wargo Budoyo received tremendous appreciation from coastal communities, it was shown that every performance of this art was always full of audiences of all ages. The audience in the show as if there is no distance, the audience can also interact with players. The phenomenon that occurs in collaborative performances of traditional arts, indicates that the collaborative packaging of traditional arts represents the packaging of shows that suits the aesthetic tastes of coastal communities. Community tastes based on their characteristics can be categorized into popular taste.
Concert visits with the music class: A Salzburg case study
Authors: Bernhofer Andreas 
Published: August 2020

AbstractMany European cities offer a vivid cultural landscape and numerous live-music opportunities. Some of the events aim at young audiences and develop cooperation projects with schools (Schwanse, 2003). The Schools@Concerts research project focuses on long-established cooperation projects between schools and concert hosts and tries to give insights into the structure of them. This article describes the Salzburg single case study, where besides the music teacher, the school students and the concert host also a didactics course from the music teacher training at the university is involved. By collecting data with interviews and questionnaires with all participating partners, the research group tries to outline the different roles within the cooperation project and compares the varying goals, tasks and expectations of the participating partners.