bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective multicentre open-label randomised controlled trial of 3-month versus 12-month dual antiplatelet therapy after implantation of the new generation biodegradable polymer sirolimus TARGET-eluting coronary stent: protocol of the TARGET DAPT trial
Authors: Yang Hongbo , Zhang Feng , Yang Ji'e , Zheng Ming , Cao Ruifen , Dai Yuxiang , Li Chenguang , Yao Kang , Qian Juying , Ge Junbo 
Published: December 2019

IntroductionDual antiplatelet therapy (DAPT) with aspirin and thienopyridine is required after placement of coronary stents to prevent thrombotic complications. However, current recommendation for duration of DAPT remains controversial. Firehawk is a biodegradable polymer applied to recessed abluminal grooves, sirolimus target-eluting stent associated with early excellent healing response and almost complete strut coverage, as well as possibly reduced myocardial ischaemic events. But the optimal DAPT duration for such a new generation stent is less known. Therefore, the present trial seeks to evaluate the safety and efficacy of 3-month versus 12-month DAPT in broad patients receiving Firehawk stents.Methods and analysisThe TARGET DAPT study is designed to access the benefits and risks of short-term (3 months) versus long-term (12 months) DAPT in preventing stent thrombosis or major adverse cardiovascular and cerebrovascular events in subjects undergoing percutaneous coronary intervention for the treatment of coronary artery obstructive lesions. The TARGET DAPT trial is a large, prospective, multicentre, randomised (1:1) non-inferiority clinical trial that will enrol 2446 subjects treated with Firehawk stents. The primary endpoint is net adverse clinical and cerebral events, a composite of all-cause death, myocardial infarction, cerebral vascular accident and major bleeding (BARC 2,3 or 5) at 18 months clinical follow-up postindex procedure.Ethics and disseminationEthics approval was obtained from the Ethics Committee of Zhongshan Hospital, Shanghai. The reference number is B2018-146R. Study findings will be made available to interested participants. Study results will be submitted for publication in a peer-reviewed journal. Also the protocol will be submitted and approved by the institutional Ethics Committee at each participating clinical centre.Trial registrationNCT03008083
Diagnostic accuracy of dynamic ultrasound imaging in partial and complete anterior cruciate ligament tears: a retrospective study in 247 patients
Authors: Breukers Manon , Haase Dorieke , Konijnenberg Stephan , Klos Tiburtius V S , Dinant Geert-Jan , Ottenheijm Ramon P G 
Published: December 2019

ObjectivesDynamic ultrasound (US) imaging shows promising possibilities for accurate imaging in diagnosing anterior cruciate ligament (ACL) tears and can be used as a point-of-care test. The aim of this study is to determine the diagnostic accuracy of dynamic US imaging for detecting partial and complete ACL tears.Methods247 patients presenting with knee complaints, who underwent dynamic US imaging as well as arthroscopy for any intra-articular knee pathology, were retrospectively evaluated. We differentiated between partial and complete ACL tears.ResultsDynamic US imaging revealed 95 of 108 arthroscopically confirmed ACL tears (sensitivity 88%, specificity 82%, positive predictive value (PPV) 79%, negative predictive value (NPV) 90%, and diagnostic OR (DOR) of 33.3). Sensitivity of US in the detection of partial ACL tears was 52%, specificity 85%, PPV 52%, NPV 84% and DOR 5.8. Complete ACL tears were depicted with a sensitivity of 79%, specificity of 89%, PPV of 63%, NPV of 95% and DOR 29.8. Multivariate regression analysis adjusting for age (dichotomised per 5 years) and previous knee surgery showed similar DOR.ConclusionThe excellent NPV for complete ACL tears indicates that dynamic US imaging can be used as an initial imaging point-of-care test. However, the clinical presentation should be taken into account, especially in case of subtotal tears. Whereas it seems relatively easy to differentiate between (small) partial ACL tears, complete ACL tears and no tears, it seems to be difficult to differentiate subtotal tears from complete tears.
Development of a conversion model between mechanical and electrical vestibular stimuli
Authors: Chen A. , Khosravi-Hashemi N. , Kuo C. , Kramer J. K. , Blouin J.-S. 
Published: December 2019

The vestibular end-organs encode for linear and angular head accelerations in space contributing to our internal representation of self-motion. Activation of the vestibular system with transmastoid electrical current has recently grown in popularity; however, a direct relationship between electrically evoked and mechanically evoked vestibular responses remains elusive in humans. We have developed and tested a mechanical-to-electrical vestibular stimulus conversion model incorporating physiological activation of primary vestibular afferents identified in nonhuman primates. We compared ocular torsional responses between mechanical (chair rotation) and model-derived electrical (binaural-bipolar) stimuli in separate experiments for an angular velocity step change (±10 deg/s over 1 s, ±4-mA peak amplitude; n = 10) and multisine angular velocities (±10 deg/s, 9.7 mA peak to peak, 0.05–1 Hz; n = 5), respectively. Perception of whole body rotation ( n = 18) to our step-change stimuli was also evaluated. Ocular torsional slow-phase velocity responses between stimulation types were similar (paired two one-sided tests of equivalence: multiple P < 0.002; one-sample t test: P = 0.178) and correlated (Pearson’s coefficient: multiple P < 0.001). Bootstrap analysis of perceived angular velocity likewise showed similarity in perceptual decay dynamics. These data suggest that central processing between stimuli was similar, and our vestibular stimulus conversion model with a conversion factor of ∼0.4 mA per deg/s for an angular velocity step change can generate electrical stimuli that replicates dynamic vestibular activation elicited by mechanical whole body rotations. This proposed vestibular conversion model represents an initial framework for using electrical stimuli to generate mechanically equivalent activation of primary vestibular afferents for use in biomedical applications and immersive reality technologies.NEW & NOTEWORTHY With the growing popularity of electrical vestibular stimulation in biomedical and immersive reality applications, a direct conversion model between electrical and mechanical vestibular stimuli is needed. We developed a model to generate electrical stimuli mimicking the physiological activation of vestibular afferents evoked by mechanical rotations. Ocular and perceptual responses evoked by mechanical and model-derived electrical stimuli were similar, thus providing a critical first step toward generation of electrically induced vestibular responses that have a realistic mechanical equivalent.
КОМБІНОВАНА ОБРОБКА ДАНИХ САМОСТІЙНОГО МОНІТОРИНГУ РІВНЯ ГЛЮКОЗИ В КРОВІ
Authors: Chuiko G. P. , Dvornik O. V. , Darnapuk Y. S. 
Published: December 2019

Самостійний моніторинг рівня глюкози в крові протягом довгого періоду є одним із засобів моніторингу стану здоров'я. Дані представленого дослідження дозволяють корегувати лікування та спосіб життя людей, хворих на діабет. Тренди, мінливість та сезонність серій є базовими для запровадження таких рішень, для чого пропонується використовувати комбіновану обробку даних. Така обробка включає в себе сингулярно-спектральний аналіз (ССА) з використанням графіків Пуанкаре та дослідження статистичної автокореляційної функції (АКФ).
Об'єкт дослідження — 67-річний чоловік з довгою історією хвороби на діабет другого типу (T2D). Тести проводились три рази на тиждень за схемою «Понеділок-Середа-П'ятниця». Загальний час виміру складає 176 тижнів, тому часова серія має довжину в N=528 семплів.
У результаті автокореляційна функція спрогнозувала сезонність серії. Сума плавного тренду, найменші коливання та залишки (шуми) і є моделлю серії. Такий підхід є стандартним для ССА. Знайдено плавний тренд із зміною. Найменший період (плюс сезонність) близький до шести місяців. Аналіз графіку Пуанкаре показує випадкову природу короткострокової варіабельності серій, тоді як довгострокова має сезонність як основне джерело.
Тренд має випуклу форму. Виявлено затримку між початком лікування інсуліном та точкою зміни. Ця затримка близька до періоду найменших коливань (близько шести місяців). Результати сингулярно-спектрального аналізу, графіків Пуанкаре та досліджень автокореляційної функції узгоджуються між собою.
Prognostic Significance of Serum Cholinesterase Level in Patients With Acute Decompensated Heart Failure With Preserved Ejection Fraction: Insights From the PURSUIT‐HFpEF Registry
Authors: Seo Masahiro , Yamada Takahisa , Tamaki Shunsuke , Hikoso Shungo , Yasumura Yoshio , Higuchi Yoshiharu , Nakagawa Yusuke , Uematsu Masaaki , Abe Haruhiko , Fuji Hisakazu , Mano Toshiaki , Nakatani Daisaku , Fukunami Masatake , Sakata Yasushi 
Published: December 2019

Background

Malnutrition is one of the most important comorbidities in patients with heart failure with preserved ejection fraction. We recently reported the prognostic significance of serum cholinesterase level and superior predictive power of
cholinesterase
level to other objective nutritional indices such as the controlling nutritional status score, prognostic nutritional index, and geriatric nutritional risk index in patients with acute decompensated heart failure. The aim of this study was to clarify the prognostic role of cholinesterase in patients with heart failure with preserved ejection fraction/acute decompensated heart failure and investigate incremental cholinesterase value.

Methods and Results

We prospectively studied 274 consecutive patients from the PURSUIT‐HFpEF (Prospective Multicenter Observational Study of Patients with Heart Failure With Preserved Ejection Fraction) study. During a follow‐up period of 1.2±0.6 years, 56 patients reached the composite end points (cardiovascular death and readmission for worsening heart failure). In the multivariable Cox analysis, cholinesterase level was significantly associated with the composite end points after adjustment for major confounders. A Kaplan–Meier analysis revealed that patients with low cholinesterase levels (stratified by tertile) had significantly greater risk of reaching the composite end points than those with middle or high cholinesterase levels (
P
=0.0025).
C
holinesterase level showed the best C‐statistics (0.703) for prediction of the composite end points among the objective nutritional indices. C‐statistics of the Meta‐Analysis Global Group in Chronic Heart Failure (MAGGIC) risk score for prediction of the composite end points were improved when cholinesterase level was added (C‐statistics, from 0.601 to 0.705;
P
=0.0408).

Conclusions

Cholinesterase
was a useful prognostic marker for prediction of adverse outcome in patients with heart failure with preserved ejection fraction/acute decompensated heart failure.
Anodal High-definition Transcranial Direct Current Stimulation over the Posterior Parietal Cortex Modulates Approximate Mental Arithmetic
Authors: Hartmann Matthias , Singer Sarah , Savic Branislav , Müri René M. , Mast Fred W. 
Published: December 2019

Abstract
The representation and processing of numerosity is a crucial cognitive capacity. Converging evidence points to the posterior parietal cortex (PPC) as primary “number” region. However, the exact role of the left and right PPC for different types of numerical and arithmetic tasks remains controversial. In this study, we used high-definition transcranial direct current stimulation (HD-tDCS) to further investigate the causal involvement of the PPC during approximative, nonsymbolic mental arithmetic. Eighteen healthy participants received three sessions of anodal HD-tDCS at 1-week intervals in counterbalanced order: left PPC, right PPC, and sham stimulation. Results showed an improved performance during online parietal HD-tDCS (vs. sham) for subtraction problems. Specifically, the general tendency to underestimate the results of subtraction problems (i.e., the “operational momentum effect”) was reduced during online parietal HD-tDCS. There was no difference between left and right stimulation. This study thus provides new evidence for a causal involvement of the left and right PPC for approximate nonsymbolic arithmetic and advances the promising use of noninvasive brain stimulation in increasing cognitive functions.
When Black Female Presence in Beauvoir’s L’ Invitée Is (Seemingly) Not Invited to The Second Sex
Authors: Jones Janine 
Published: December 2019

Abstract
This paper argues that in L’ Invitée and in The Second Sex, Black presence, especially “Black female presence,” functions as the fundamental field against which White female consciousnesses are able to make sense of themselves as subjects and objects in their relationships with Others, including when the Others are themselves. Considering The Second Sex and L’ Invitée as together providing Beauvoir’s understanding of gender allows for an account of how “Black female presence”—in the form of the White imaginary’s idea of Black women—is present and operational in The Second Sex.
“The Past Is an Appeal”
Authors: Altman Meryl 
Published: December 2019

Abstract
As the International Simone de Beauvoir Society celebrates the relaunch of Simone de Beauvoir Studies, the author looks back with gratitude to longtime editor Yolanda Patterson and reviews what the journal’s thirty-year history has to tell us about Beauvoir scholarship, past, present, and future. Topics discussed include the history of the Society; engagements with Beauvoir from the perspectives of literary criticism, philosophy, and the social sciences; and controversies over Beauvoir’s character, her response to the Occupation, her relationship to Sartre, and her legacy for feminism.
Il “nome” nel Maqṣad di al-Ġazālī: Note di grammatica araba e logica aristotelica sulla tradizione dei commenti al Peri Hermeneias
Authors: la Martire Corrado 
Published: December 2019

Abstract
In his famous treatise “The ultimate scope in the explanation of the meanings of God’s beautiful names” (al-Maqṣad al-asnā fī šarḥ maʿānī asmāʾ Allāh al-ḥusnā), al-Ġazālī (d. 1111) presents a broad introduction on the concept of “name”. As is well known, the topic of the names of God represents an important moment in Muslim theology and mysticism. The argument uses philosophical concepts, starting from the discussion about the relationship between name and named subject. These concepts can be traced directly to the tradition of the commentaries on Aristotle’s De interpretatione (Περὶ ἑρµηνείας), which allowed al-Ġazālī to provide a logic-semantic solution to the identity between name and named subject, and subtends his indebtedness to the Peripatetic tradition.
Readiness for delivering early palliative care: A survey of primary care and specialised physicians
Authors: Sorensen Anna , Le Lisa W , Swami Nadia , Hannon Breffni , Krzyzanowska Monika K , Wentlandt Kirsten , Rodin Gary , Zimmermann Camilla 
Published: December 2019

Background: Evidence supporting early palliative care is based on trials of specialised palliative care, but a more sustainable model might involve mainly primary providers. Aim: The aim of this study was to compare the characteristics of physicians providing primary and specialised palliative care, their attitudes towards early palliative care and their perception of having sufficient resources for its provision. Design: Survey distributed by mail and e-mail. Specialised providers were defined as both receiving palliative care referrals from other physicians and not providing palliative care only for their own patients. Setting/participants: A total of 531 physicians providing palliative care in Canada (71% participation) participated in the study. Results: Of the participants, 257 (48.4%) provided specialised and 274 (51.6%) primary care. Specialists were more likely to have palliative care training (71.8% vs 35.2%), work in urban areas (94.1% vs 75.6%), academic centres (47.8% vs 26.0%) and on teams (82.4% vs 16.8%), and to provide mainly cancer care (84.4% vs 65.1%) (all p < 0.001). Despite strongly favouring early palliative care, only half in each group agreed they had resources to deliver it; agreement was stronger among family physicians, those working on teams and those with greater availability of community and psychosocial support. Primary providers were more likely to agree that renaming the specialty ‘supportive care’ would increase patient comfort with early palliative care referral (47.4% vs 35.5%, p < 0.001). Conclusion: Despite strongly favouring the concept, both specialists and primary providers lack resources to deliver early palliative care; its provision may be facilitated by team-based care with appropriate support. Opinions differ regarding the value of renaming palliative care.
Comparison of laparoscopic surgery versus traditional laparotomy for the treatment of emergency patients
Authors: Cui Ning , Liu Jun , Tan Haiyan 
Published: December 2019

Objective To investigate the clinical efficacy of laparoscopic gastrointestinal emergency surgery and postoperative complications. Methods Data for 604 patients undergoing emergency gastrointestinal surgery between January 2013 and December 2018 were analyzed retrospectively. Treatment efficacy and postoperative complications were compared between 300 patients (control group) undergoing traditional laparotomy and 304 patients (observation group) undergoing laparoscopic surgery. Results Clinical features were significantly better in the observation group than in the control group, including duration of surgery (59.12 ± 10.31 minutes vs. 70.34 ± 12.83 minutes), intraoperative blood loss (41.21 ± 10.45 mL vs. 61.38 ± 9.97 mL), postoperative pain score (1.25 ± 0.25 points. vs. 5.13 ± 0.43 points), length of hospital stay (5.13 ± 0.24 days vs. 7.05 ± 0.13 days), and time to free activity (13 ± 2.96 hours vs. 22 ± 3.02 hours). The total complication incidence in the observation group was 3.9%, compared with 16% in the control group (16%). No significant differences in direct medical costs were recorded between the observation and control groups. Conclusions For patients undergoing emergency gastrointestinal surgery, laparoscopic surgery resulted in better clinical outcomes than traditional laparotomy without incurring additional costs. The potential clinical benefits of emergency laparoscopic gastrointestinal surgery warrant further study.
Elite Ice Hockey Goalkeepers Have a High Prevalence of Hip and Groin Problems Associated With Decreased Sporting Function: A Single-Season Prospective Cohort Study
Authors: Wörner Tobias , Clarsen Benjamin , Thorborg Kristian , Eek Frida 
Published: December 2019

Background: The modern style of goalkeeping in ice hockey is thought to predispose athletes to hip and groin problems. However, little is known about the magnitude of these problems in elite goalkeepers. Purpose: To describe the incidence, prevalence, and severity of hip and groin problems in elite ice hockey goalkeepers over the course of a single season. Study Design: Descriptive epidemiology study. Methods: We invited all elite Swedish ice hockey goalkeepers (n = 128) to participate in this prospective cohort study. Every second week, players reported hip and groin problems experienced within the past 14 days on the Oslo Sports Trauma Research Center Overuse Injury Questionnaire (OSTRC-O), classifying problems into “all” and “substantial” hip and groin problems. Three times during the season (pre-, mid-, and end-season), players reported hip and groin function on the Hip and Groin Outcome Score (HAGOS) as well as on the OSTRC-O. Results: A total of 101 goalkeepers participated in the study (83.3% male [seniors, 44.1%; juniors, 39.2%], 16.7% female). The cumulative incidences of all hip and groin problems and substantial hip and groin problems were 69% (95% CI, 59%-79%) and 36% (95% CI, 26%-46%), respectively. The average biweekly prevalence for all hip and groin problems and substantial hip and groin problems was 28.1% (95% CI, 25.0%-31.3%) and 10% (95% CI, 8.7%-11.4%), respectively. Among all the reported hip and groin problems, 16.9% (n = 70) were acute, 83.1% (n = 343) were because of overuse, and 15.5% (n = 64) led to time loss. HAGOS did not differ in the pre-, mid-, or end-season. Players reporting hip and groin problems on the OSTRC-O had significantly worse HAGOS scores than players without problems ( P < .01). Conclusion: Hip and groin problems are highly prevalent in elite ice hockey goalkeepers. During a competitive season, 69% of players experienced hip and groin problems and 36% of players suffered from substantial problems. The vast majority of problems were because of overuse, not leading to time loss but related to reduced self-reported hip and groin function.
Overexpression of rice jacalin-related mannose-binding lectin (OsJAC1) enhances resistance to ionizing radiation in Arabidopsis
Authors: Jung In Jung , Ahn Joon-Woo , Jung Sera , Hwang Jung Eun , Hong Min Jeong , Choi Hong-Il , Kim Jin-Baek 
Published: December 2019

Abstract
Background
Jacalin-related lectins in plants are important in defense signaling and regulate growth, development, and response to abiotic stress. We characterized the function of a rice mannose-binding jacalin-related lectin (OsJAC1) in the response to DNA damage from gamma radiation.

Results
Time- and dose-dependent changes of OsJAC1 expression in rice were detected in response to gamma radiation. To identify OsJAC1 function, OsJAC1-overexpressing transgenic Arabidopsis plants were generated. Interestingly, OsJAC1 overexpression conferred hyper-resistance to gamma radiation in these plants. Using comparative transcriptome analysis, genes related to pathogen defense were identified among 22 differentially expressed genes in OsJAC1-overexpressing Arabidopsis lines following gamma irradiation. Furthermore, expression profiles of genes associated with the plant response to DNA damage were determined in these transgenic lines, revealing expression changes of important DNA damage checkpoint and perception regulatory components, namely MCMs, RPA, ATM, and MRE11.

Conclusions
OsJAC1 overexpression may confer hyper-resistance to gamma radiation via activation of DNA damage perception and DNA damage checkpoints in Arabidopsis, implicating OsJAC1 as a key player in DNA damage response in plants. This study is the first report of a role for mannose-binding jacalin-related lectin in DNA damage.