bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Profile, Response to therapy and outcomes of post-ischemic intestinal stenosis Secondary to Acute Mesenteric Venous Thrombosis: a retrospective case series study
Authors: Sun Shilong , Wang Xinyu , Chu Chengnan , Duan Zehua , Yang Chao , Zong Jiao , Liu Baochen , Wu Xingjiang , Li Qiurong , Ding Weiwei 
Published: June 2020

Abstract
Background

Acute mesenteric venous thrombosis (AMVT) can not only cause acute bowel infarction but result in post-ischemic intestinal stenosis (PIIS), which is rarely reported.
Methods

Consecutive patients diagnosed with PIIS secondary to AMVT (during the post-thrombotic course, confirmed segmental bowel stenosis) from January 2010 to June 2018 were enrolled. We evaluated the clinical profile, response to therapy, and outcomes of this complication managed at the intestinal stroke center in China. Clinical data are retrospectively analyzed and Wilcoxon signed-rank test was used to evaluate the efficiency of conservative treatment.
Results

42 patients with PIIS secondary to AMVT were evaluated. 20 (5-150) days after discharge for AMVT, symptoms of PIIS appeared, and the interval between symptom onset and consultation was 29.5 (2-180) days. In addition, abdominal pain (90.5%), abdominal distension (76.2%), weight loss (71.4%), and nausea or vomiting (54.8%) were the common presentations. Hypoproteinemia was observed in 61.9% of patients, while leukocytosis, anemia and electrolyte disorders were present in 11.9%, 45.2% and 35.7% of patients, respectively. CT excluded thrombosis recurrence and revealed extensive collateral circulation or portal cavernous transformation in 83.3% of patients. Enterography was required only in 81.0% of patients, with positive findings in all patients, including complete obstruction (23.5%), intestinal stricture (64.7%), and extensive mucosal erosion (11.8%). Prompt conservative treatment achieved significantly increases of albumin and pre-albumin levels and correction of electrolyte disorders (all p < 0.05). However, only 4 (9.5%) patients improved after conservative therapy and laparotomy was required in other patients. A median length of 20 (2-100) cm of involved bowel was resected, mainly involving the jejunum (76.3%). Only 1 patient died due to uncontrolled transverse colon bleeding, and other patients’ postoperative courses were uneventful.
Conclusion

During the post-thrombotic course, clinicians should be aware of the possibility of PIIS in patients with symptoms of ileus and hypoproteinemia. Patients may respond to conservative therapy; however, the majority of patients warrant surgical resection.
Relationship between the atlantodental interval and T1 slope after atlantoaxial fusion in patients with rheumatoid arthritis
Authors: Ha Byeong Jin , Won Yu Deok , Ryu Jeil , Han Myung-Hoon , Cheong Jin Hwan , Kim Jae Min , Chun Hyoung-Joon , Bak Koang-Hum , Bae In-Suk 
Published: June 2020

Abstract
Background
Atlantoaxial fusion has been widely used for the treatment of atlantoaxial instability (AAI). However, atlantoaxial fusion sacrifices the motion of atlantoaxial articulation, and postoperative loss of cervical lordosis and aggravation of cervical kyphosis are observed. We investigated various factors under the hypothesis that the atlantodental interval (ADI) and T1 slope may be associated with sagittal alignment after atlantoaxial fusion in patients with rheumatoid arthritis (RA).
Methods
We retrospectively investigated 64 patients with RA who underwent atlantoaxial fusion due to AAI. Radiological factors, including the ADI, T1 slope, Oc-C2 angle, cervical sagittal vertical axis, and C2-C7 angle, were measured before and after surgery.
Results
The various factors associated with atlantoaxial fusion before and after surgery were compared according to the upper and lower preoperative ADIs. There was a significant difference in the T1 slope 1 year after surgery (p = 0.044) among the patients with lower preoperative ADI values. The multivariate logistic regression analysis showed that the preoperative ADI (> 7.92 mm) defined in the receiver-operating characteristic curve analysis was an independent predictive factor for the increase in the T1 slope 1 year after atlantoaxial fusion (odds ratio, 4.66; 95% confidence interval, 1.37–15.84; p = 0.014).
Conclusion
We found an association between the preoperative ADI and difference in the T1 slope after atlantoaxial fusion in the patients with RA. A preoperative ADI (> 7.92 mm) was an independent predictor for the increase in the T1 slope after atlantoaxial fusion. Therefore, performing surgical treatment when the ADI is low would lead to better cervical sagittal alignment.
Total Versus Conventional Laparoscopic Cyst Excision and Roux-en-Y Hepaticojejunostomy in Children with Choledochal Cysts: A Case-Control Study
Authors: Liu Fei , Xu Xiaogang , Lan Menglong , Tao Boyuan , Li Le , Wu Qiang , Chai Chengwei , Zeng Jixiao 
Published: June 2020

Abstract
Background: To compare the efficacy of total and conventional laparoscopic hepaticojejunostomy (TLH and CLH) in children with choledochal cysts (CDCs).Methods: Patients undergoing TLH and CLH between August 2017 and December 2018 were retrospectively analyzed. Intraoperative blood loss, time for jejunum-co-jejunum anastomosis, time to oral intake, postoperative hospital stay, hospitalization expenses, postoperative complications and perioperative laboratory values were compared.Results: All 55 patients (TLH=30, CLH=25) were successfully treated without conversion to open surgery. In the TLH and CLH groups, the time to oral intake was 3.57±0.19 d and 4.56±0.27 d, respectively (t=3.07, P<0.01), the postoperative hospital stay was 5.50±0.28 d and 7.00±0.74 d (t=2.03, P<0.05), the hospitalization expenses were CNY 40085±2447 and CNY 26084±2776 (t=3.79, P<0.001). There were no significant differences in intraoperative blood loss (9.57±3.28ml vs 8.2±1.13 ml, t=0.37, P=0.72) and time for jejunum-co-jejunum anastomosis (80.5±2.46 min vs 75.00±2.04 min, t=1.68, P=0.10). The median follow-up periods of TLH and CLH group were 17 and 16 months respectively. Overall comlication rates were comparable between two groups (10% vs 8%, c²=0.07, P=0.79).Conclusions: TLH in children with CDCs has the advantages of rapid gastrointestinal functional recovery and short hospitalization. However, hospitalization is relatively expensive.
Characteristics and Trends of Chronic Pain Among Chinese Middle Aged and Elderly People in the Past Decades: Based on China Health and Retirement Longitudinal Study
Authors: Wang Yao , Luo Erdan , Bian Ying 
Published: June 2020

Abstract
Background: As one of the most common symptoms perplexing aged people, an understanding about chronic pain is needed with the aging of population in China. This study aimed to figure out the characteristics and trends of chronic pain among Chinese middle aged and elderly people in the past decades. Methods: The nationwide survey data of China Health and Retirement Longitudinal Study from 2008 to 2015 were analyzed to describe the characteristics of chronic pain, including its prevalence, intensity and location, pain patients’ quality of life, treatment, and recognitions on pain. Chi-square test and t test were used to compare chronic pain in different years and among participants in different demographic groups. Binary logistic regression was applied to explore factors affecting chronic pain. Result: A total of 62481 middle aged and elderly participants were investigated on chronic pain in 2008, 2011, 2012, 2013 and 2015, and 30.13% of them suffered from chronic pain. The factors affecting chronic pain included age, gender,education, living area, disability, chronic disease, occupation, and food expenditure. Chronic pain located mostly in waist, accounting 13.60% of body pain, followed by legs and knees. Patients with mild, moderate, and severe pain accounted 37.38%, 29.70% and 32.92%, respectively. Pain patients slept 5.86 (±2.05) hours one night in average, which was significantly shorter than overall participants. There were 75.20% of pain patients suffered from depression, which was significantly more than that among overall participants. From 2013 to 2015, the proportion of pain patients receiving no treatment decreased from 39.35% to 26.80%, and the prevalence of taking traditional Chinese medicine, western medicine, acupuncture, and professional massage therapy all increased. Patients’ recognition on pain became diversified by time. Conclusion: There were 30.13% of Chinese middle age and elderly people suffering from chronic pain, which were more likely to happen in female, rural, and chronic diseases patients. Chronic pain interfered significantly on patients’ quality of life, and mainly located in waist, legs, and knees. In recent years, more patients received treatment to relieve pain, which might indicate a gradual awareness of chronic pain among middle age and elderly in China.
“We’re in Good Hands There.” - Acceptance, Barriers and Facilitators of a Primary Care-based Health Coaching Programme for Children With Mental Health Problems: A Qualitative Study (Prima-quo)
Authors: Decke Siona , Deckert Karina , Lang Martin , Laub Otto , Loidl Verena , Schwettmann Lars , Grill Eva 
Published: June 2020

Abstract
Background:About 17 % of children aged 3-17 years are affected by a mental health problem (MHP). Office-based paediatricians are the first in line to be contacted. Nevertheless, even for less severely affected patients, referral rates to specialised care are constantly high. A major statutory health insurance fund introduced a Health Coaching (HC) programme, including a training concept for paediatricians, standardized guidelines for actions, and additional payments to strengthen primary care consultation for MHP and to decrease referrals to specialized care. The aim of this study was to examine how the HC is perceived and implemented in daily practice to indicate potential strengths and challenges.Methods:In 2017 and 2018, a series of guideline-based interviews were conducted by phone with HC-developers, HC-qualified paediatricians, parents and patients (≥14 years) treated according to the HC programme. Paediatricians were selected from a Bavarian practice network. Parents of patients with the four most common MHP diagnoses were approached by their health insurance. All interviews were recorded and transcribed verbatim. Structuring content analysis derived from Mayring was used for analysis. Sample size was determined by saturation.Results:11 paediatricians, 3 developers, 22 parents and four adolescents were included. Families were generally satisfied with paediatric care received in the programme’s context. The HC supported paediatricians’ essential role as consultants and improved their diagnostic skills. Time and financial restrictions as well as patients’ challenging family structures were reported as major barriers to success.Conclusion: The HC programme is perceived as a facilitator for more patient-centeredcare, however, structural barriers remain.
Protective Factors and Risk Factors in Patients with COVID-19 Pneumonia and/or Infection
Authors: Li Jia-Xia , Wan Li , Feng Yuan , Zuo Huilin , Ren Jiecheng , Zhao Qian , Xia Mingwu , Zhang Xiaochu 
Published: June 2020

Abstract
This study examined 50 COVID-19 patients who have been cured in Anhui Province, China. The protective factors and risk factors for these patients were investigated. By comparing CT-negative and CT-positive patients, we found protective factors in blood: lymphocytes, eosinophils number and %, basophils%, reticulocyte%, high fluorescence reticulocyte ratio, and reticulocyte absolute value. Comparing patients with underlying disease and without underlying disease, we found protective factors in blood: lymphocytes%, basophils%, large platelets, and low-fluorescent reticulocyte ratio. Regarding the biochemistry indicators, albumin/globulin, apolipoprotein and prealbumin can be considered as protective factors for patients without lung symptoms. Urea, glucose, total bile aicd, creatinine and hypersensitivity CRP can be considered as risk factors for patients with underlying diseases. For patients with repeatedly negative and positive results in nucleic acid tests, they were at a medium level in terms of both protective and risk factors, explaining the mild symptoms and repeatedly results in nucleic acid tests.
Hyperferritinemia and Gallbladder Wall Oedema as Early Markers of a Severe Dengue Infection in a Developing Nation.
Authors: Moras Errol Christopher , Raj Naveen , Achappa Basavaprabhu , Holla Ramesh , Madi Deepak , Mahalingam Soundarya 
Published: June 2020

Abstract
Background: Several chemokines, cytokine and biomarkers have previously been depicted in the pathogenesis of severe dengue fever. Despite the presence of clinical parameters, there have been no proven markers, during the period of defervescence to predict the progression of non-severe dengue cases to the severe dengue phase in the adult population. This study was undertaken to determine the likelihood of serum ferritin levels and gallbladder wall thickness measured within four days of febrile illness, as potential early predictors of severe dengue illness.Methods: A prospective study was conducted among people visiting tertiary care hospitals in Mangalore, India. 131 participants who presented within 4 days of fever and who had Dengue NS1 antigen card test positive and confirmed Dengue IgM by ELISA were recruited in the study. Blood was tested for serum ferrritin levels and gallbladder wall thickness was measured using ultrasonography. Results: 33.6% (44) of the cases had severe dengue and had a hospital stay of 6-8 days. Serositis, shock, hepatitis and renal failure were some of the significant complications associated with severe dengue cases. Rising transaminases, serum ferritin, H score and thrombocytopenia correlated well with the dengue severity.66 cases had evidence of gallbladder oedema and 89% of these cases developed severe dengue. Ferritin levels greater than 3825 ng/dl was established as a good cut-off for the severity of dengue with a sensitivity of 72.7%. Conclusion: In poor socioeconomic and developing nation like India there exists the need for low priced laboratory and radiological tests to predict the severity of dengue cases so that they can be optimally treated to have a good outcome. We demonstrated the use of serum ferritin levels and gallbladder wall thickness >3mm detected early, during the third or fourth day of febrile illness, as potential markers of progression of dengue to its severity
Long-term effects of ambient PM2.5 on hypertension in multi-ethnic population from Sichuan province, China: a study based on 2013 and 2018 health service surveys
Authors: Xu Jiayue , Zhang Yuqin , Yao Minghong , Wu Gonghua , Duan Zhanqi , Zhao Xing , Juying Zhang 
Published: June 2020

Abstract
Background
Hypertension, a major risk factor of many sever chronic diseases and leading cause of global disease burden, is reported associated with exposure to PM2.5. China’s high PM2.5 pollution level has become a major public health issue. However, existing studies from China on the effect of PM2.5 exposure on hypertension have got inconsistent results with very limited investigation into the multi-ethnic people. This study adds multi-ethnic evidence from Sichuan Province, southwestern China, and assesses ethnic differences of PM2.5 exposure effect on hypertension.
Methods
We pooled large cross-sectional data from two surveys conducted in Sichuan province in 2013 and 2018 to exam the effect of long-term exposure to PM2.5 on prevalence of hypertension in adults aged 30 years old and above. Community-specified annual PM2.5 concentration was estimated using satellite data. Logistic regression was applied to examine the association between long-term exposure to PM2.5 and hypertension prevalence in the whole population, specific ethnic populations and population (including Han and ethnic minority people) living in same areas.
Results
31462 participants with an average age of 56 years old were included. The average exposure concentration was 32.8 µg/m3. The proportions of the Han, the Tibetan, the Yi, and other ethnic people were 89.2%, 7.3%, 3.2%, and 0.3%, respectively. The adjusted odds ratio (OR) was 1.08 (95% CI, 1.04–1.12) for a 10 µg/m3 PM2.5 concentration increment for the whole population. The adjusted ORs for the Han, the Tibetan, and the Yi were 1.08 (95% CI, 1.04–1.12), 0.03 (95% CI, 0.00-0.27), and 1.75 (95% CI, 1.28–2.38) for a 10 µg/m3 PM2.5 concentration increment, respectively. Stratification analysis found stronger associations in participants with chronic diseases and Yi minority population.
Conclusion
Long-term exposure to PM2.5 may increase the risk of hypertension prevalence in Chinese multi-ethnic adults. Stronger associations were found in people with chronic disease and Yi minority group.
Hyaluronic Acid versus Alpha-2-Macroglobulin Intra-Articular Injections for Amelioration of Knee Posttraumatic Osteoarthritis: A Rat Model
Authors: Wang Shaowei , Zhu Mengbo , Guo Yanjing , Yang Ruijia , Chang Yaqiong , Zhao Bin , Wang Zhenyu , Wei Lei 
Published: June 2020

Abstract
Background: The study was performed to evaluate whether intra-articular injection of A2M has better effect than current commonly used Hyaluronic Acid (HA) injection therapy to attenuate cartilage degeneration in a rat anterior cruciate ligament transection (ACLT) osteoarthritis (OA) model.Method: In vivo effects of A2M and HA on cartilage degeneration were evaluated in rat surgery induced ACLT OA models. 100 rats were randomly divided into four groups: (a) Sham surgery + saline (Sham + S), (b) ACLT + A2M, (c) ACLT+HA, or (d) ACLT + saline (ACLT+S). The animals were sacrificed at 12 weeks after surgery. Histological staining was performed to assess cartilage damage. The concentration of MMP-13 and sGAG in synovial fluid lavages was measured using ELISA and spectrophotometric quantitative determination. OA-related gene expression was quantified by qPCR.Result: Indian ink staining showed that articular cartilage surface treated by A2M was relatively intact compared with the animals treated by ACLT with saline or HA injection. Histological staining indicated that early supplemental intra-articular injection of A2M attenuated OA pathogenesis in the rat ACLT model compared with the animals treated with saline and HA. However, supplemental intra-articular injection of HA showed no significant effect on cartilage protection for post traumatic OA compared with saline treatment. Elisa results showed A2M reduced the concentration of MMP-13 in synovial fluid compared with HA treatment group and other groups. RT-qPCR indicated that supplemental intra-articular A2M inhibits catabolism and enhances anabolic metabolism, while there was no significant difference in the expression of OA-related genes between ACLT+HA group and ACLT+S group. Conclusion: In rat model, intra-articular injection of A2M had obvious protective effects on cartilage degeneration compared with HA treatment. Major indexes of joint degeneration decreased, providing strong evidence for its intra-articular inhibitory effect. Meanwhile, we found no significant alleviation of articular cartilage pathogenesis in HA treated group, which suggests that the efficacy of HA is questionable and possibly transient, although it is extensively used to improve syndromes.
Coagulation-Flocculation: A potential Application for Mosquito Larval Source Management (LSM) with No Insecticide Resistance
Authors: Li XinRan , Huang Minsheng , Leng PeiEn , Lu XinYu , Xiao Bing 
Published: June 2020

Abstract
Background: Mosquito control is an essential step to eliminate mosquito-borne diseases. Larval mosquitoes have a more limited home range and lower resistance to adverse environment than adults, thus can be ideal targets for vector control in some cases. Coagulation-flocculation technology, which could be used for water treatment in breeding sites of several vector mosquito species, can significantly change both the distribution of organic particles and surface sediment characteristics in water environment. The aim of this study was to explore the effect, principle and possibility of using coagulation-flocculation technology in immature mosquitoes killing.Method: In laboratory, chlorine-free tap water was treated with Poly Aluminum Chloride (PACl, sewage treatment using). The oviposition preference of gravid Culex pipiens pallens, the hatching of mosquito eggs and the survival amount of mosquito larvae were observed, and the pupa amounts were recorded each day.Results: Coagulation-flocculation treatment could improve the oviposition preference of Culex pipiens pallens to some extent (compared with ordinary chlorine-free tap water), but not significantly (p=0.345). After treatment, mosquitoes laid eggs in chlorine-free tap water were 31.88% more than those laid in untreated water. Coagulation-flocculation affected the larvae’s survival by physical means: Ⅰ) alum floc layer increases the difficulty of larvae foraging, leads larvae starving to death; (Ⅱ) the little floc particles adhere to the surface of larvae, which stops larvae from floating upward to breathe. As a result, the alum floc layer had a good killing effect on the mosquito larvae, presented the half lethal time (LT50) of 2d, the 90% lethal time (LT90) of 8.7±7.3 ~ 14±4.5 d, and the pupation rate of 0 ~ (6.5±0.5)%, respectively.Conclusions: PACl coagulation-flocculation produced lots of alum flocs, which may attract more gravid mosquitoes for laying eggs, and was shown to be highly active against 1st~2nd instar larvae. The principle of this technology illustrates this method won’t develop insecticide resistance. In this study, coagulation-flocculation technology is considered to be a new potential approach to a sustainable, low-impact and low-cost mosquito control method.
Unemployment and health-related quality of life in melanoma patients during the COVID-19 pandemic: A web-based cross-sectional study
Authors: Guo Yeye , Shen Minxue , Zhang Xu , Xiao Yi , Zhao Shuang , Yin Mingzhu , Bu Wenbo , Wang Yan , Chen Xiang , Su Juan 
Published: June 2020

Abstract
Background

The outbreak of coronavirus disease-2019 (COVID-19) ineluctably caused social distancing and unemployment, which may bring additional health risks for patients with cancer. To investigate the association of the pandemic-related impacts with the health-related quality of life (HRQoL) among patients with melanoma during the COVID-19 pandemic, we conducted a cross-sectional study among Chinese patients with melanoma.
Methods

A self-administered online questionnaire was distributed to melanoma patients through social media. Demographic and clinical data, and pandemic-related impacts (unemployment and income loss) were collected. HRQoL was determined by the Functional Assessment of Cancer Therapy-General (FACT-G) and its disease-specific module (the melanoma subscale, MS).
Results

A total of 70 patients with melanoma completed the study. The mean age of the patients was 55.2 ± 14.8 years, 45.7% (32/70) were male, and 21.4% (15/70) were unemployed since the epidemic. Unemployment of the patients and their family members and income loss were significantly associated with a lower FACT-G score, while the MS score was associated with the unemployment of the patients’ family members.
Conclusions

Our findings suggested that unemployment is associated with impaired HRQoL in melanoma patients during the COVID-19 epidemic.