bluuebunny/crossref_metadata_2025_split huggingface dataset:
Theoretical and applied aspects of creating a unified information accounting system of pharmaceutical and medical products in Ukraine
Authors: Revyatskyy I. Yu. , Boiko A. I. 
Published: December 2020

In modern conditions of reforming the Ukrainian Health Care system based on the introduction of innovative digital information technologies, the development of a methodology for the computerization of pharmaceutical information exchange processes is relevant.
The purpose of our study was to develop a methodology for creating a unified accounting system (UAS) of information on pharmaceutical and medical products (Ph&MP) in Ukraine (taking into account the current standards of computer systems for structuring and fixing information, as well as in accordance with international standards for automated identification of information about Ph&MP.
The objects of the research were: scientific and specialized publications devoted to the issue of the implementation of a system of accounting and tracking of medical and health care in the EU, USA, Canada;pharmaceutical information with tracking and recording the established information flows in computer databases.The main research is based on the methodology of pharmaceutical informatics: creation of pharmaceutical computer databases, coding of pharmaceutical products. The method of system analysis processed publications on the types of Ph&MP encodings in the EU, USA, Canada.
In the scientific work, the international standards for the sale of information in two-dimensional shaded codes of the DataMatrixECC 200 standard are highlighted, which is one of the information blocks on the basis of which the development of the UAS Ph&MP database structure should be based.The structure and interconnection of information blocks for the accounting of Ph&MP units using GTIN and serial numbers in the database of structural units of business entities of the pharmaceutical market of Ukraine have been developed.
A systematic analysis of the types of Ph&MP encodings in the EU countries, the USA, and Canada has been carried out.Highlighted rational approaches to the formation of coding and accounting for Ph & MP, taking into account national characteristics. The basis of the integral structure of the UAS Ph&MP with basic information blocks has been developed.Approaches and principles to the methodology of its formation are given, taking into account the current standards of computer systems for the structuring and fixing of information, as well as in accordance with international standards for automated identification of information about Ph&MP. The requirements for the compliance of computer databases of structural units of business entities with modern standards for preserving pharmaceutical information necessary about medicines when accounting are presented.
Authors: Fadilah Mariatul , Jiawei Alyssa Poh , Cakra Muhammad Prima , Syakurah Rizma Adlia 
Published: December 2020

Introduction: SARS-CoV-2 is an ongoing outbreak of pneumonia, SARS-CoV-2 originally originated in bats, was transmitted to humans via pangolins or other wild animals. The latest data reported on May 6, 2020, globally confirmed cases were 16,341,920 and cases died as many as 650,805 people. This study aims to determine family knowledge of comorbid diseases in the Covid-19 era through online seminars. Methods: This study used a quasi experimental pre and post-test design. A total of 379 samples were collected using a questionnaire before and after the online seminar, covering age, gender, education, religion and occupation. Descriptive and analytical analysis used the Wilcoxon test and Mcnemar test to determine changes in the role of the family towards comorbid diseases before and after the online seminar. Results: The majority of respondents were 24-30 years old (33.5%), female (60.9%), Muslim (94.5%). The Wilcoxon test results showed there was no significant difference in the mean family knowledge before and after online seminar (p value = 0.893). The statistical test results using the Mcnemar test also found no significant difference before and after the online seminar (p = 0.115). Conclusion: Online methods such as online seminars can provide participants with satisfaction and measurable changes in their knowledge and behavior. This study concludes that the level of family knowledge about comorbidities in the Covid-19 era through online seminars is still not good.;
Key words: Family Knowledge; Complementary Diseases; Covid-19; Online seminar
Authors: Sulistyawati Wiwin , Rahayu Kun Ika Nur , Dhanti Adelia Yogi Pratiwi Rama 
Published: December 2020

Intoduction: Effective communication enhancement is a component of patient safety. The application of SBAR communication on handover and the performance of nurses in providing nursing care at inpatient room are factors that affect the quality of health services. This study aims to identify the relation between SBAR communication in handovers and the performance of nurses in implementing nursing care at inpatient room of the hospital. Methode:Research design correlation analysis with the cross-sectional approach. Sampling techniques used consecutive sampling. Respondents were given informed consent, dissemination of questionnaires about the implementation of SBAR communication and nurses performance. The health department researcher has developed through a google form. The independent variable is the SBAR communication in handover, while the nurse's performance in implementing nursing care is the dependent variable. Data tested using spearman rank test. Result: Based on statistical test results obtained, p-value = 0.000 < α 0.005 so that H0 is rejected H1 is accepted .Conclusion:It means there is a relationship between SBAR communication in handovers and the performance of nurses in implementing nursing care at Inpatient Room.Based on the results of this study, the Head of Nursing is expected to motivates nurse to implement SBAR communication at handover in order to improve the performance of nurses in providing nursing care at Inpatient Room. ;
Keywords: SBAR communication, handover, nurse performance, nursing care
Cyborgs en Centroamérica: Ciberespacio, Políticas Oposicionales y Pensamiento Feminista Decolonial
Authors: Reyes-Rivas Roxana 
Published: December 2020

El contexto centroamericano se caracteriza por una situación periférica tanto en la producción tecnocientífica, como en lo que se refiere al acceso desigual a los productos tecnocientíficos. Esto es particularmente evidente en cuanto a las Tecnologías de la Información y Comunicación (TIC). Se discutirán las características de esta región en lo que concierne al ciberespacio facilitado por la Internet y su apropiación por las mujeres, en particular en grupos organizados. Se utilizará un enfoque teórico decolonial ciberfeminista, pues la región centroamericana no solamente ocupa un lugar periférico dentro del sistema-mundo, sino que, por razones culturales y económicas, el acceso de las mujeres al uso de las tecnologías computacionales e informáticas ha sido aún más restringido, constituyéndolas así en la periferia de la periferia. A través de dicho enfoque se podrá comprender la manera particular en que se utilizan las TIC en nuestra región como instrumento para ejercer sus capacidades y políticas oposicionales que, como diría la pensadora chicana Chela Sandoval, dan pie a conformar el cyborg centroamericano, como expresión de la imaginería propuesta por Haraway (1985). Este enfoque teórico podrá verse funcionando mediante la discusión del ejemplo de un grupo que se opone a situaciones que precarizan la existencia, como el golpe de Estado en Honduras (Feministas en Resistencia).
A história da pessoa com deficiência e da educação especial em tempos de inclusão
Authors: Rodrigues Ana Paula Neves , Lima Cláudia Araujo de 
Published: December 2020

O presente artigo teve por objetivo, realizar uma breve exposição acerca da história das pessoas/estudantes com deficiência, para entender os “reflexos” no campo educacional, assim como, levantar a importância trazida através da garantia de Direitos tangentes a essa população, até então, antes esquecida. Atualmente, a Educação Especial na Perspectiva da Educação Inclusiva é respaldada através de leis, documentos internacionais e políticas voltadas à inclusão, que subsidiarão o texto do referido artigo e que respaldam, tanto o acesso como a permanência de estudantes com deficiência. Entender a história das pessoas/estudantes com deficiência, ao longo dos tempos, torna-se valoroso, pois, as lutas e a garantia dos seus direitos “provocam” possibilidades de mudanças para o contexto educacional de uma forma geral. Afinal, TODOS possuem o direito à educação, mediante a qualidade de ensino, que foi por muito tempo, negada à grande parte da população.Pessoas com Deficiência. Educação Especial. Educação Inclusiva. Direitos HumanosThe history of the disabled people and the special education in times of inclusionAbstractThe present article’s had as objective to accomplish a short exposition about the history of the disabled people/students to understand the reflections in the educational field, as well as, to bring up the importance throughout the guarantee of the rights tangents to the population, theretofore forgotten. Nowadays, the Special Education in the Inclusive Education Perspective is supported through the law, international documents and policies aimed at the inclusion, for them will be given the subsidies to this article and also back up both the access and the stay of the disabled students. To understand the history of the disabled people/students over times become so relevant for the fights and the assurance of their rights that provoke possibilities of changes to the educational context in a general way. After all, ALL have the right to education, through the teaching quality, that a long time was denied to the most of the population.Disabled People. Special Education. Inclusive Education. Human Rights
Investigation of duck plague virus in hoar areas of Bangladesh
Authors: Hossen A , Rahman MH , Ali MZ , Yousuf MA , Hassan MZ , Giasuddin M 
Published: December 2020

Duck plague (DP) is the most important infectious disease of geese, ducks and free-ranging water birds. The present study was conducted to determine the prevalence of duck plague virus followed by isolation and identification. For these purposes, a total of 155 cloacal swabs samples were collected randomly from duck of different haor areas of Bangladesh including 45 (41 surveillance and 4 clinical) samples from Netrokona; 42 (40 surveillance and 2 clinical) samples from Kishoregonj; 30 samples from Brahmanbaria and 38 samples from Sunamganj. The samples were processed and pooled (1:5 ratio) for initial screening of target polymerase gene of duck plague virus by polymerase chain reaction (PCR) method. All the samples of a positive pool were then tested individually for identifying the individual positive samples. The result showed that out of 155 samples, 41 (26.45%) were found positive in which 17 were from Netrokona, where 15 (36.58%) were from surveillance samples and 2 (50%) were from clinical sample; 16 were from Kishoregonj, where 14 (35%) were from surveillance samples and 2 (100%) were from clinical sample; 2 (6.6%) were from Brahmanbaria and 5 (13.15%) were from Sunamganj. These positive samples were inoculated into 9-10 days embryonated duck eggs (EDE) through chorioallantoic membrane (CAM) route for the isolation of virus. The EDE died earlier was also chilled, and in a similar way, the CAMs were collected and again performed PCR for id entification of virus. Out of 41 PCR positive samples, 26 samples were isolated and reconfirmed by PCR. Subsequently, DPV was isolated in primary duck embryo fibroblasts cell culture and confirmed by observing cytopathic effect (CPE).
Bang. J. Livs. Res. Vol. 26 (1&2), 2019: P. 73-78
Interaction of drugs with lipid raft membrane domains as a possible target
Authors: Tsuchiya Hironori , Mizogami Maki 
Published: December 2020

Introduction: Plasma membranes are not the homogeneous bilayers of uniformly distributed lipids but the lipid complex with laterally separated lipid raft membrane domains, which provide receptor, ion channel and enzyme proteins with a platform. The aim of this article is to review the mechanistic interaction of drugs with membrane lipid rafts and address the question whether drugs induce physicochemical changes in raft-constituting and raft-surrounding membranes.
Methods: Literature searches of PubMed/MEDLINE and Google Scholar databases from 2000 to 2020 were conducted to include articles published in English in internationally recognized journals. Collected articles were independently reviewed by title, abstract and text for relevance.
Results: The literature search indicated that pharmacologically diverse drugs interact with raft model membranes and cellular membrane lipid rafts. They could physicochemically modify functional protein-localizing membrane lipid rafts and the membranes surrounding such domains, affecting the raft organizational integrity with the resultant exhibition of pharmacological activity. Raft-acting drugs were characterized as ones to decrease membrane fluidity, induce liquid-ordered phase or order plasma membranes, leading to lipid raft formation; and ones to increase membrane fluidity, induce liquid-disordered phase or reduce phase transition temperature, leading to lipid raft disruption.
Conclusion: Targeting lipid raft membrane domains would open a new way for drug design and development. Since angiotensin-converting enzyme 2 receptors which are a cell-specific target of and responsible for the cellular entry of novel coronavirus are localized in lipid rafts, agents that specifically disrupt the relevant rafts may be a drug against coronavirus disease 2019.
O impacto da pandemia de COVID-19 nas emoções dos trabalhadores da saúde e na aprendizagem profissional
Authors: Neves Vanusa Nascimento Sabino , Sabino Raquel do Nascimento , Assis Valdegil Daniel de , Santos Stefany Thyene  Albuquerque dos 
Published: December 2020

O objetivo foi problematizar sobre as emoções mais prevalentes nos profissionais de saúde que estão atuando na linha de frente da assistência aos pacientes portadores de COVID-19 e sobre a maneira como os sentimentos por eles experimentados se relacionam com as necessidades de aprendizagem profissional qualificadora ao enfrentamento da pandemia. Realizou-se uma pesquisa qualitativa, descritiva e exploratória a partir da transcrição e análise de vídeos jornalísticos de acesso público hospedados na plataforma You Tube no primeiro semestre do ano de 2020. O conteúdo dos vídeos selecionados se referiu a entrevistas fornecidas pelos profissionais de saúde da linha de frente do combate à pandemia para as empresas jornalísticas brasileiras. Dentre os resultados, evidenciou-se que o medo é um sentimento prevalente entre os profissionais da saúde. Mesmo diante de jornada de trabalho extenuante e do medo, os profissionais tem buscado a qualificação profissional através das estratégias que conciliem o trabalho e aprendizagem. Conclui-se que a crise sanitária atual tem impactado os profissionais que procuram conciliar o sentimento de medo com o dever funcional, mantendo-se firmes na assistência aos doentes portadores de COVID-19 e procurando se capacitar para o enfrentamento.
L-Citrulline Supplementation Increases Plasma Nitric Oxide Levels and Reduces Arginase Activity in Patients With Type 2 Diabetes
Authors: Shatanawi Alia , Momani Munther S. , Al-Aqtash Ruaa , Hamdan Mohammad H , Gharaibeh Munir N. 
Published: December 2020

Type 2 diabetes mellitus (T2DM) is becoming a major contributor to cardiovascular disease. One of the early signs of T2DM associated cardiovascular events is the development of vascular dysfunction. This dysfunction has been implicated in increasing the morbidity and mortality of T2DM patients. One of the important characteristics of vascular dysfunction is the impaired ability of endothelial cells to produce nitric oxide (NO). Additionally, decreases in the availability of NO is also a major contributor of this pathology. NO is produced by the activity of endothelial NO synthase (eNOS) on its substrate, L-arginine. Reduced availability of L-arginine to eNOS has been implicated in vascular dysfunction in diabetes. Arginase, which metabolizes L-arginine to urea and ornithine, competes directly with NOS for L-arginine. Hence, increases in arginase activity can decrease arginine levels, reducing its availability to eNOS and decreasing NO production. Diabetes has been linked to elevated arginase and associated vascular endothelial dysfunction. We aimed to determine levels of plasma NO and arginase activity in (T2DM) patients and the effects of L-citrulline supplementation, a natural arginase inhibitor, on inhibiting arginase activity in these patients. Levels of arginase correlated with HbA1c levels in diabetic patients. Twenty-five patients received L-citrulline supplements (2000 mg/day) for 1 month. Arginase activity decreased by 21% in T2DM patients after taking L-citrulline supplements. Additionally, plasma NO levels increased by 38%. There was a modest improvement on H1Ac levels in these patients, though not statistically significant. The effect of L-citrulline on arginase activity was also studied in bovine aortic endothelial cells (BAECs) grown in high glucose (HG) conditions. HG (25 mM, 72 h) caused a 2-fold increase in arginase activity in BAECs and decreased NO production by 30%. L-citrulline (2.5 mM) completely prevented the increase in arginase activity and restored NO production levels. These data indicate that L-citrulline can have therapeutic benefits in diabetic patients through increasing NO levels and thus maintaining vascular function possibly through an arginase inhibition related pathway.
Alkannin-Induced Oxidative DNA Damage Synergizes With PARP Inhibition to Cause Cancer-Specific Cytotoxicity
Authors: Chang Mingxin , Wang Hongge , Niu Jiajing , Song Yan , Zou Zhihua 
Published: December 2020

Background:Oncogenic transformation is associated with elevated oxidative stress that promotes tumor progression but also renders cancer cells vulnerable to further oxidative insult. Agents that stimulate ROS generation or suppress antioxidant systems can drive oxidative pressure to toxic levels selectively in tumor cells, resulting in oxidative DNA damage to endanger cancer cell survival. However, DNA damage response signaling protects cancer cells by activating DNA repair and genome maintenance mechanisms. In this study, we investigated the synergistic effects of combining the pro-oxidative natural naphthoquinone alkannin with inhibition of DNA repair by PARP inhibitors.Methods and Results:The results showed that sublethal doses of alkannin induced ROS elevation and oxidative DNA damage in colorectal cancer but not normal colon epithelial cells. Blocking DNA repair with the PARP inhibitor olaparib markedly synergized with alkannin to yield synergistic cytotoxicity in colorectal cancer cells at nontoxic doses of both drugs. Synergy between alkannin and olaparib resulted from interrupted repair of alkannin-induced oxidative DNA damage and PARP-trapping, as it was significantly attenuated by NAC or by OGG1 inhibition and the non-trapping PARP inhibitor veliparib did not yield synergism. Mechanistically, the combination of alkannin and olaparib caused intense replication stress and DNA strand breaks in colorectal cancer cells, leading to apoptotic cancer cell death after G2arrest. Consequently, coadministration of alkannin and olaparib induced significant regression of tumor xenograftsin vivo, while each agent alone had no effect.Conclusion:These studies clearly show that combining alkannin and olaparib can result in synergistic cancer cell lethality at nontoxic doses of the drugs. The combination exploits a cancer vulnerability driven by the intrinsic oxidative pressure in most cancer cells and hence provides a promising strategy to develop broad-spectrum anticancer therapeutics.
Blood–Brain Barrier Leakage Is Increased in Parkinson’s Disease
Authors: Al-Bachari Sarah , Naish Josephine H. , Parker Geoff J. M. , Emsley Hedley C. A. , Parkes Laura M. 
Published: December 2020

BackgroundBlood–brain barrier (BBB) disruption has been noted in animal models of Parkinson’s disease (PD) and forms the basis of the vascular hypothesis of neurodegeneration, yet clinical studies are lacking.ObjectiveTo determine alterations in BBB integrity in PD, with comparison to cerebrovascular disease.MethodsDynamic contrast enhanced magnetic resonance images were collected from 49 PD patients, 15 control subjects with cerebrovascular disease [control positive (CP)] and 31 healthy control subjects [control negative (CN)], with all groups matched for age. Quantitative maps of the contrast agent transfer coefficient across the BBB (Ktrans) and plasma volume (vp) were produced using Patlak analysis. Differences in Ktrans and vp were assessed with voxel-based analysis as well as in regions associated with PD pathophysiology. In addition, the volume of white matter lesions (WMLs) was obtained from T2-weighted fluid attenuation inversion recovery (FLAIR) images.ResultsHigher Ktrans, reflecting higher BBB leakage, was found in the PD group than in the CN group using voxel-based analysis; differences were most prominent in the posterior white matter regions. Region of interest analysis confirmed Ktrans to be significantly higher in PD than in CN, predominantly driven by differences in the substantia nigra, normal-appearing white matter, WML and the posterior cortex. WML volume was significantly higher in PD compared to CN. Ktrans values and WML volume were similar in PD and CP, suggesting a similar burden of cerebrovascular disease despite lower cardiovascular risk factors.ConclusionThese results show BBB disruption in PD.
ANALISIS INOVASI PENGEMBANGAN ORGANISASI PADA PEMERINTAH DESA WUKIRSARI KABUPATEN SLEMAN
Authors: Nugroho Hanantyo Sri , Rahmawati Agustina 
Published: December 2020

Studi ini mengkaji faktor-faktor keberhasilan dari pengembangan organisasi pada pemerintahan desa. Sasaran penelitian ini adalah inovasi sistem administrasi pemerintahan, inovasi sistem pelayanan masyarakat, inovasi ekonomi wisata, inovasi bidang pendidikan di Pemerintah Desa Wukirsari Kabupaten Sleman. Dalam memahami proses inovasi tersebut, peneliti menggunakan teori implementasi inovasi. Titik tekan teori tersebut adalah faktor individu, faktor struktur dan faktor budaya. Artinya, strategi inovasi pengembangan organisasi Pemerintah Desa Wukirsari dapat dilihat dari bagaimana individu yang ada pada pemerintah desa dan masyarakat desa tersebut berjalan dengan baik, maka dapat memengaruhi struktur dan budaya yang ada. Hasil penelitian adalah pelaksanaan inovasi pengembangan organisasi secara elektronik dapat meningkatkan kecakapan pemerintah desa dan masyarakat Desa Wukirsari. Adapun, beberapa inovasi program pelayanan publik tersebut, yakni inovasi sistem administrasi pemerintahan berupa Sistem Data Administrasi Kependudukan (Sidampak), inovasi sistem pelayanan masyarakat berupa sistem Lukadesi, Ulangtahunku dan Sidanik, inovasi ekonomi dan wisata berupa program konservasi burung hantu, Tyto Alba, inovasi bidang pendidikan berupa program sekolah pintar.
Kata kunci: Pengembangan Organisasi, Inovasi sistem administrasi pemerintahan, Inovasi sistem pelayanan masyarakat, Inovasi ekonomi wisata, Inovasi bidang pendidikan.