bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accumulation of Skeletal Muscle T Cells and the Repeated Bout Effect in Rats
Authors: DEYHLE MICHAEL R. , CARLISLE MEGHAN , SORENSEN JACOB R. , HAFEN PAUL S. , JESPERSON KYLIE , AHMADI MOHADESEH , HANCOCK CHAD R. , HYLDAHL ROBERT D. 
Published: December 2019

ABSTRACT

Purpose
The purpose of this investigation was to characterize skeletal muscle T-cell accumulation after contraction-induced muscle damage and test the hypothesis that T cells contribute to postdamage muscle protection (i.e., the repeated bout effect) in a way reminiscent of their role in adaptive immunity.

Methods

In vivo lengthening contractions were used to model the repeated bout effect and contralateral repeated bout effect in rats. Intramuscular T-cell subsets were characterized by flow cytometry after single and repeated bouts of lengthening contractions, and an adoptive T-cell transfer experiment was done to test whether T cells from muscle damage-experienced rats can confer protection from injury to damage-naive rats.

Results
Electrically stimulated lengthening contractions elicited the repeated bout effect, but not the contralateral repeated bout effect. Although leukocytes (CD45+) were scarce in undamaged muscle (2.1% of all cells), substantially more (63% of all cells) were observed after a single bout of lengthening contractions. Within the leukocyte population were several subsets of T cells, including conventional CD4+, CD8+, memory, and regulatory T cells. In contrast, a minimal increase in T cells was observed after a second bout of lengthening contractions. Conventional CD4+ T cells (FoxP3−) were the most abundant subset in muscle after lengthening contractions. Adoptive T-cell transfer from damage-experienced rats did not confer protection to damage-naive recipient rats.

Conclusions
The robust T-cell accumulation, particularly the CD4 subset, after contraction-induced damage suggests a role for these cells in muscle repair and adaptation to muscle damaging contractions. Moreover, T cells are unlikely to mediate the protective adaptations of the repeated bout effect in a manner similar to their role in adaptive immunity.
Hyperbaric Oxygen Therapy in Sports Musculoskeletal Injuries
Authors: MOGHADAM NAVID , HIEDA MICHINARI , RAMEY LINDSAY , LEVINE BENJAMIN D. , GUILLIOD RENIE 
Published: December 2019

ABSTRACT
Hyperbaric oxygen therapy (HBOT) is a well-established treatment for a variety of conditions. Hyperbaric oxygen therapy is the administration of 100% oxygen breathing in a pressure vessel at higher than atmospheric pressure (1 atmosphere absolute = 101 kPa). Typically, treatment is given daily for between 1 and 2 h at pressures of 2.0 to 2.8 ATA, depending on the indication. Sporting injuries are often treated over 3 to 10 sessions. Hyperbaric oxygen therapy has been documented to be effective and is approved in 14 medical indications by the Undersea and Hyperbaric Medical Society, including, but not limited to, carbon monoxide poisoning, compromised skin grafts and flaps, crush injuries, necrotizing soft tissue infections, and nonhealing ulcers with arterial insufficiencies. Recently, HBOT for sports musculoskeletal injuries is receiving increased attention. Hyperbaric oxygen therapy may allow injured athletes to recover faster than normal rehabilitation methods. Any reduction in collegiate and professional athletes’ rehabilitation period can be financially significant for top-level sports teams; however, further research is required to confirm HBOT’s benefits on sports musculoskeletal injuries. The purpose of this review to discuss the current understanding of HBOT as a treatment modality for common musculoskeletal injuries in sport medicine. Moreover, we will highlight the advantages and disadvantages of this modality, as well as relevant clinical and research applications.
Heavy Resistance Training in Breast Cancer Patients Undergoing Adjuvant Therapy
Authors: CEŠEIKO RŪDOLFS , THOMSEN SIMON NØRSKOV , TOMSONE SIGNE , EGLĪTIS JĀNIS , VĒTRA AIVARS , SREBNIJS ANDREJS , TIMOFEJEVS MIHAILS , PURMALIS EGĪLS , WANG EIVIND 
Published: December 2019

ABSTRACT

Background and Purpose
Adjuvant breast cancer therapy may reduce maximal muscle strength, muscle mass, and functional performance. Although maximal strength training (MST) has the potential to counteract this debilitating outcome and is shown to be superior to low- and moderate-intensity strength training, it is unknown if it can elicit effective adaptations in patients suffering treatment-induced adverse side effects.

Methods
Fifty-five newly diagnosed stage I to III breast cancer patients (49 ± 7 yr) scheduled for adjuvant therapy were randomized to MST or a control group. The MST group performed 4 × 4 repetitions of dynamic leg press at approximately 90% of one-repetition maximum (1RM) twice a week for 12 wk.

Results
In the MST group, improvements in 1RM (20% ± 8%; P < 0.001) were accompanied by improved walking economy (9% ± 8%) and increased time to exhaustion during incremental walking (9% ± 8%; both P < 0.01). Moreover, the MST group increased 6-min walking distance (6MWD; 10% ± 7%), and chair rising (30% ± 20%) and stair climbing performance (12% ± 7%; all P < 0.001). All MST-induced improvements were different from the control group (P < 0.01) which reduced their 1RM (9% ± 5%), walking economy (4% ± 4%), time to exhaustion (10% ± 8%), 6MWD (5% ± 5%), chair rising performance (12% ± 12%), and stair climbing performance (6% ± 8%; all P < 0.01). Finally, although MST maintained estimated quadriceps femoris muscle mass, a decrease was observed in the control group (7% ± 10%; P < 0.001). The change in 1RM correlated with the change in walking economy (r = 0.754), time to exhaustion (r = 0.793), 6MWD (r = 0.807), chair rising performance (r = 0.808), and stair climbing performance (r = 0.754; all P < 0.001).

Conclusions
Lower-extremity MST effectively increases lower-extremity maximal muscle strength in breast cancer patients undergoing adjuvant therapy and results in improved work economy, functional performance, and maintenance of muscle mass. These results advocate that MST should be considered in breast cancer treatment.
Evaluating the Risks and Benefits of Genetic and Pharmacologic Interventions for Down Syndrome: Views of Parents
Authors: Riggan Kirsten A. , Nyquist Christina , Michie Marsha , Allyse Megan A. 
Published: December 2019

AbstractResearchers are investigating new technologies to mitigate or prevent symptoms of Down syndrome (DS), including chromosome silencing and pharmacotherapy. We surveyed parents of individuals with DS to assess their opinions on two hypothetical scenarios describing prenatal chromosome silencing and pediatric pharmacological intervention to improve neurocognition in children with DS. Although a slim majority of participants supported the availability of both therapies, respondent support was contingent on the risks presented, including the risk of miscarriage in the prenatal intervention and the impact of pharmaceuticals on their children's personality. Many parents expressed ambivalence, articulating a desire to improve their children's quality of life but requiring more safety and efficacy research before agreeing to a genetic or pharmacological intervention.
Adverse Medication Events Related to Hospitalization in the United States: A Comparison Between Adults With Intellectual and Developmental Disabilities and Those Without
Authors: Erickson Steven R. , Kamdar Neil , Wu Chung-Hsuen 
Published: December 2019

Abstract
This study examined the proportion of hospitalizations associated with adverse medication events (AMEs) for adults with intellectual and developmental disabilities (IDD) and adults from the general population in the United States using the 2013 National Inpatient Sample (NIS) dataset of the Healthcare Cost and Utilization Project (HCUP). Adults with IDD had greater odds of having a hospitalization associated with an AME than the general adult population. Unadjusted odds ratios (95% CI) for hospitalization due to any medication for IDD was 2.47 (2.31–2.65). In the multivariate logistic regression model, IDD was significantly associated, with an odds ratio of 1.28 (1.19–1.38). Adults who have IDD are at greater risk of having a hospital admission due to an AME.
ANALISIS NILAI-NILAI TOLERANSI DALAM KURIKULUM PENDIDIKAN AGAMA
Authors: Mustaqim Mujahidil 
Published: December 2019

Today's religious tolerance is a very sexy problem with a high sensitivity shock in the midst of a pluralistic society. Religion can be a field of inner conditioning as well as an object of propaganda by certain parties to destroy a civilization. So this article examines what the Islamic Religious Education curriculum looks like in an effort to strengthen religious tolerance. This article was prepared using the library research method. The results showed that the objectives and content of the curriculum in strengthening the attitude of religious tolerance have accommodated the needs and conditions of today's age. The content of the Religious Education curriculum is not dominated by the content of beliefs and worship, but also the content of human relationships such as religious tolerance. Curriculum 2016 Religious Education is considered to have been present to overcome the problem of religious intolerance. So it is not only guarded by citizenship education subjects only. This curriculum analysis is done by examining from two points of view, First, the rationalization of the 2016 curriculum syllabus in religious education. Second, core competencies and material distribution maps are taught as an embodiment of the formation of religious tolerance.
Abstrak
Sikap tolerasi beragama pada hari ini merupakan permasalahan yang sangat seksi dengan daya kejut sensitifitas yang tinggi di tengah-tengah masyarakat yang majemuk. Agama bisa menjadi ladang penyejuk batin sekaligus objek propaganda pihak-pihak tertentu untuk menghacurkan suatu peradaban. Maka artikel ini mengkaji seperti apa kurikulum Pendidikan Agama Islam dalam upaya penguatan sikap toleransi beragama. Artikel ini disusun menggunakan metode library research. Hasil penelitian menunjukkan bahwa tujuan dan konten kurikulum dalam penguatan sikap toleransi agama sudah mengakomodasi kebutuhan dan kondisi zaman hari ini. Konten kurikulum Pendidikan Agama tidak didomonasi oleh konten keyakinan dan ibadah semata akan tetapi juga konten hubungan sesama manusia seperti toleransi agama. Kurikulum 2016 Pendidikan Agama dinilai sudah hadir untuk mengatasi persoalan intoleransi agama. Sehingga tidak hanya dikawal oleh mata pelajaran pendidikan kewarganegaraan semata. Analisis kurikulum ini dilakukan dengan menelaah dari dua sudut pandang, yaitu Pertama, rasionalisasi silabus kurikulum 2016 mata pelajaran pendidikan agama. Kedua, kompetensi inti dan peta sebaran materi yang diajarkan sebagai perwujudan pembentukan sikap toleransi agama.
Biocomposite scaffold preparation from hydroxyapatite extracted from waste bovine bone
Authors: Ho Quoc-Phong , Tao The-Duong , Huynh Lien-Huong , Wang Meng-Jiy 
Published: December 2019

AbstractThis study was conducted to fabricate scaffold from polylactic acid (PLA) and hydroxyapatite (HA) extracted from waste bovine bone for enhancing both mechanical and biocompatible properties. After pretreatment in dilute NaOH solution, the bone was calcined at 900°C for 6 h, ball milled and converted to HA. Factors that affect the formation of HA were investigated. Experimental results showed that HA particles with crystal size < 100 nm and 99% crystallinity could be obtained at 90°C, pH 11 and 35 mM H3PO4 solution followed by 4 h calcination at 900°C. By using non-solvent induced phase separation method, PLA scaffolds with pore size and surface area of 22.6 μm and 25.7 m2/g, respectively, containing different hydroxyapatite were successfully prepared. Tensile strength of scaffolds increased due to effective support by HA grafted collagen. PLA scaffolds containing HA were more degradable than PLA scaffolds and PLA scaffolds containing HA grafted collagen. Cell culture results showed that cell density increased significantly on porous scaffolds than that on the dense scaffolds. Moreover, cell density also increased significantly on the scaffold containing HA grafted collagen than that on the scaffold with pure HA.
Biofabrication of zinc oxide nanoparticles, characterization and cytotoxicity against pediatric leukemia cell lines
Authors: Liu Zuliang , Chen Fang , Lu Zhongde 
Published: December 2019

AbstractIn this work, we showed the synthesis of zinc oxide nanoparticles (ZnO NPs) using leaf extract of Punica granatum. Characterization results showed the synthesis of stable ZnO NPs with average size of 7 nm. Fourier transform infrared (FT-IR) and zeta potential results confirmed the capping of ZnO NPs with plant extract polyphenols. X-ray diffraction (XRD) and selected area electron diffraction (SAED) examinations showed the crystalline nature of prepared ZnO NPs. Further, the cytotoxic properties of the green synthesized ZnO NPs are examined against pediatric leukemia cells and the morphology of cells was studies under microscope. The results of cytotoxicity and microscopic images revealed the dose dependent cytotoxicity, indicating their prospects for the development of novel techniques and materials for pediatric leukemia cancer therapy.
Isolation of biosurfactant producing bacteria from Potwar oil fields: Effect of non-fossil fuel based carbon sources
Authors: Sohail Rafeya , Jamil Nazia 
Published: December 2019

AbstractBiosurfactants are surface-active metabolites produced by microorganisms. Biosurfactants tend to solubilize hydrocarbons in the surrounding environment, by reducing surface tension and increasing carbon uptake. In this study, isolation of biosurfactant producing bacteria and effect of renewable, non-fossil fuel based carbon sources on production were assessed. Oil field produced water was collected from Potwar oil fields and thirteen strains were isolated. Strains were screened for biosurfactant production by hemolysis test, emulsification index test, emulsification assay, oil displacement test, drop collapse test, tilted glass slide test and oil coated agar emulsification test. Strains were further screened for maximum production on cost effective renewable carbon source e.g. glucose, waste glycerol and animal fat. Promising strains were identified as Bacillus subtilis (MH142143), Pseudomonas aeruginosa (MH142144), Bacillus tequilensis (MH142145) and Bacillus safensis (MH142146) by 16S rRNA gene sequencing. Among all isolates, highest biosurfactant production on glucose (37%), glycerol (48%) and animal fat oil (49%), after 24 h cultivation was by Pseudomonas aeruginosa. Biosurfactant showed similarity to rhamnolipids by Thin Layer Chromatography (TLC). Assessment of bioactive propertiaes of rhamnolipid showed strong antimicrobial activity against Bacillus spp. Future investigations can be focused on application of these strains in environmental as well as industrial sectors.
Fournier’s gangrene and intravenous drug abuse: an unusual case report and review of the literature
Authors: Zingaro Michele Del , Boni Andrea , Vermandois Jacopo Adolfo Rossi De , Paladini Alessio , Lepri Emanuele , Ursi Pietro , Cirocchi Roberto , Turco Morena , Gaudio Gianluca , Nogara Andrea , Mearini Ettore 
Published: December 2019

AbstractFournier’s gangrene is a potentially fatal emergency condition characterized by necrotizing fasciitis and supported by an infection of the external genital, perineal and perianal region, with a rapid and progressive spread from subcutaneous fat tissue to fascial planes.In this case report, a 52-year-old man, with a history of hepatitis C-virus (HCV)-related chronic liver disease and cocaine use disorder for which he was receiving methadone maintenance therapy, was admitted to the Emergency Department with necrotic tissue involving the external genitalia.Fournier’s gangrene is usually due to compromised host immunity, without a precise cause of bacterial infection; here it is linked to a loco-regional intravenous injection of cocaine. A multimodal approach, including a wide surgical debridement and a postponed skin graft, was needed. Here we report this case, with a narrative review of the literature.
Exploring Preference to Avoid or Seek Help in Person and Online Among College Students with Suicidal Ideation
Authors: Wilks Chelsey R. , Yee Ang Sin , Wang Xiyao , Arunagiri Vinushini , Ward-Ciesielski Erin F. 
Published: December 2019

Objectives: Suicidal thoughts, for which college students are at risk, tend to be negatively associated with intentions to seek therapy, particularly among college-aged men. Emerging research suggests college students may seek psychological help online; however, factors that explain why they avoid help and/or may prefer online help remain unknown. Method: 816 college students completed measures of suicidal ideation, help-seeking intentions, and theoretical mediators and moderators of their relationship. Results: Suicidal ideation was associated with stronger preference for online help among female, but not male respondents. The indirect effect of suicidal ideation on help negation via interpersonal difficulties was positive where self-concealment was high but negative where it was low. This pattern, however, was not found for online help preference. Conclusions: Online interventions can augment suicide prevention and intervention for college students. However, suicidal male students may be less likely to utilize online help sources. The mechanisms underlying this gender difference remain unclear. More research is needed to understand how help-negation in college-aged men can be addressed in online intervention platforms.
Social Support Versus Emotion Regulation: Mediators of Attachment and Psychological Problems After Social Exclusion
Authors: Szkody Erica , Mckinney Cliff 
Published: December 2019

Introduction: Secure parental attachment improves the perception of available social support and the socialization of emotion regulation strategies. Research has suggested that both perceived social support and emotion regulation help individuals reappraise stressful situations as less stressful. Individuals under stress are at an increased risk for psychological problems. Method: The current study examined whether social support, emotion regulation, and psychological inflexibility mediated the relation between parental attachment and psychological problems after a social exclusion task. Results: Results indicated that secure parental attachment was associated with an increased ability to up-regulate emotions and with an increase in the perception of available social support. Secure attachment to either parent was indirectly associated with psychological problems reported after social exclusion. Discussion: Indirect effects were found only for pathways from attachment through emotion regulation strategies, which suggests that emotion regulation may be a driving factor between attachment to parental figures and stress induced psychological problems. Further results, limitations, and implications were discussed.
A Texting Intervention in Latino Families to Reduce ED Use: A Randomized Trial
Authors: DeCamp Lisa Ross , Godage Sashini K. , Valenzuela Araujo Doris , Dominguez Cortez José , Wu Linxuan , Psoter Kevin J. , Quintanilla Kassandra , Rivera Rodríguez Tatiahna , Polk Sarah 
Published: December 2019

BACKGROUND AND OBJECTIVES:
Latino children in immigrant families experience health care disparities. Text messaging interventions for this population may address disparities. The objective of this study was to evaluate the impact of a Spanish-language text messaging intervention on infant emergency department use and well care and vaccine adherence.

METHODS:
The Salud al Día intervention, an educational video and interactive text messages throughout the child’s first year of life, was evaluated via randomized controlled trial conducted in an urban, academic pediatric primary care practice from February 2016 to December 2017. Inclusion criteria were publicly insured singleton infant &lt;2 months of age; parent age &gt;18, with Spanish as the preferred health care language; and at least 1 household cellular phone. Primary outcomes were abstracted from the electronic medical record at age 15 months. Intention-to-treat analyses were used.

RESULTS:
A total of 157 parent-child dyads were randomly assigned to Salud al Día (n = 79) or control groups (n = 78). Among all participants, mean parent age was 29.3 years (SD: 6.2 years), mean years in the United States was 7.3 (SD: 5.3 years), and 87% of parents had limited or marginal health literacy. The incidence rate ratio for emergency department use for the control versus intervention group was 1.48 (95% confidence interval: 1.04–2.12). A greater proportion of intervention infants received 2 flu vaccine doses compared with controls (81% vs 67%; P = .04).

CONCLUSIONS:
This Spanish-language text messaging intervention reduced emergency department use and increased flu vaccine receipt among a population at high risk for health care disparities. Tailored text message interventions are a promising method for addressing disparities.
Slovaks on Display. Otherness of the ‘Eastern Brothers’ at the Czechoslavic Ethnographic Exhibition in Prague 1895
Authors: Ducháček Milan 
Published: December 2019

Abstract
This paper is devoted to how the Slovaks were staged, encountered and recognized by the Czechs at the Czechoslavic Ethnographic Exhibition organized in Prague in 1895. The Slovaks, living during the last period of the Hungarian Kingdom, were perceived by the Czechs as an ostensibly familiar collective of ‘Slavic relatives.’ The less the Czech urban society in the last decades of the 19th century kept its ties with the slowly, but inevitably modernized countryside, the more the picture of the ‘Czechoslavic’ imagined community required a different area for placing its ‘native cottages’ into. In reconceptualizing the modern Czech ‘geography of knowledge’, even the most notable Czech specialists in Slavic studies have adopted the notion that Slovaks were in fact an ‘eastern branch’ of the ‘Czechoslavic people settled in Bohemia, Moravia, Silesia as well as the Northwest of Hungary’. Consequently, the idea of an ethnocentric, ‘national’ exhibition needed a demonstrative extension of the ‘Czech territory’ on to the East. To achieve a public demonstration of the idea, the later renowned architect Dušan Jurkovič invited a small group of people from the Trenčín and Zvolen/Detva regions to act as ‘Slovaks’ at the exhibition and so they did, wearing ‘typical’ folk costumes, singing and dancing in a peculiar style. They were viewed as a strangely exotic ‘Slovak colony’ by visitors and Czech journalists alike. The public response to the show only reinforced the petrification of the Czech collective stereotype of the ‘Slovak people’ as an underdeveloped poor community, ‘unspoiled’ by ‘western’ civilization, yet still resisting Hungarization. This ingrained discourse of ‘otherness’ survived among most of the Czechs until the establishment of the Czechoslovak republic in 1918, resulting in a growing wave of mutual misunderstandings.
The Buddhist Temple in the Imperial City of Saint Petersburg. A Different Way of Cultural Integration
Authors: Tangad Oyungerel 
Published: December 2019

Abstract
This article intends to examine the founding and functioning of the Buddhist temple in Saint Petersburg at the turn of the 20th century presented within the context of a cosmopolitan urban landscape. Moreover, it demonstrates the forms and aims of the sociopolitical activity of scholars originating from the Rozen School, which contributed to the emergence of the temple. As an example of specifically Russian orientalism, this scholarly activity enabled thinking in the categories of ethnic pluralism and principles of multiculturalism in the national policy of the Russian Empire in the discussed period, thus constituting one of the key elements which enabled the foundation of the temple.