bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case analysis of service‐member trauma processing related to art therapy within a military‐intensive outpatient program
Authors: Maltz Brenda , Hoyt Tim , Uomoto Jay , Herodes Megan 
Published: January 2020

AbstractObjectivesArt therapy has been widely used in clinical settings and has shown preliminary success in military trauma. This case study describes a mask‐making art therapy directive facilitated by a board‐certified art therapist as an adjunct to group posttraumatic stress disorder (PTSD) treatment in a military‐intensive outpatient program.MethodsDescribed are clinical outcome measures, linguistic analysis of a personal journal, evaluation of this service‐member's artwork, and experiences in the program.ResultsMask‐making, as a trauma‐focused group‐art therapy directive, expanded the understanding of treatment progress reflected in journal notes, mask imagery, and by a change in linguistic indices of trauma processing, despite an overall increase in PTSD symptoms as he confronted his traumatic experiences. He reported improvement in coping and successfully returned to full military duty following treatment.ConclusionsThis case study suggests that art therapy and written narrative, combined with standardized self‐report assessments, may more accurately indicate improvement in overall PTSD treatment.
Suitability of the multidimensional scale of perceived social support as a measure of functional social support among incarcerated adults with major depressive disorder
Authors: Wittenborn Andrea K. , Natamba Barnabas K. , Rainey Melinda , Zlotnick Caron , Johnson Jennifer 
Published: January 2020

AbstractThe multidimensional scale of perceived social support (MSPSS) is a 12‐item measure of functional social support (SS); however, the psychometric properties of the MSPSS have not been evaluated in prisoners. We used measures of known‐groups validity, convergent and discriminant validity, internal consistency reliability and factor structure to assess the suitability of the MSPSS for measuring SS among 184 individuals in prison in the U.S., who were diagnosed with depression. The MSPSS was correlated with scores on scales measuring related constructs (i.e., loneliness), and uncorrelated with unrelated constructs (i.e., verbal ability). Correlations among items of the MSPSS on the same subscale were large, and small to moderate among items of different subscales. The overall Cronbach's α for the scale was 0.93. Confirmatory factor analysis showed that the theorized three‐factor solution for the MSPSS (i.e., significant other, family, and friends) provided a good fit for the data. We recommend using the MSPSS to measure perceived SS among incarcerated individuals.
Narrative identities of overseas Filipino domestic worker community in Macao (SAR) China
Authors: Vargas Marenel C. , Garabiles Melissa R. , Hall Brian J. 
Published: January 2020

AbstractDomestic workers comprise roughly one‐fourth of the total number of overseas Filipino workers (OFWs). They leave the Philippines primarily to provide financial assistance to their families they leave behind. Most of the existing studies investigated the problems they experience at work and with their families. Some studies focused on how they cope with these problems. However, little is known about the narrative identities of this group of labor migrants. This study addresses this gap by identifying the narrative identities of the community of Filipino domestic workers in Macao Special Administrative Region, China. This study utilized qualitative interviews to plot the identities into a three‐part timeline: Premigration, during migration, and imagined future. Results show that, before migration, the community of domestic workers identifies as hands‐on mothers and inadequate mothers. During migration, work‐ and family‐related identities are present: Modern‐day slave, inadequate, fighter, self‐sacrificing, employer's family, and hands‐on mother. In an imagined future, the community of domestic workers identifies as successful retired OFWs, reconciled life partners, hands‐on mothers, and inadequate mothers. Findings highlight the multiple, interacting identities in community narratives and their corresponding effects on experiences. Implications on policies and programs for this labor migrant group are discussed.
LncRNA NKILA inhibits the proliferation and promotes the apoptosis of CSCC cells by downregulating miRNA‐21
Authors: Wang Jinou , Zhu Zhi , Qiu Hui , Liu Chang , Chang Xiaoying , Qi Yafei , Lv Qingjie 
Published: January 2020

AbstractLong noncoding RNA (lncRNA) NKILA has been well studied in several types of human tumors as a tumor suppressor, while its involvement in cervical squamous cell carcinoma (CSCC) remains unclear. In our studies, we found that serum NKILA was at lower levels and serum microRNA‐21 (miRNA‐21) was at higher levels in patients with early stage CSCC than in the healthy female. Altered expression of NKILA and miRNA‐21 can effectively separate patients with CSCC at an early stage from healthy controls. Serum levels of NKILA were significantly and negatively correlated with miRNA‐21 in patients with CSCC but not in normal controls. Overexpression of NKILA mediated the inhibited expression of miRNA‐21 in CSCC cells, but mimic transfection of miRNA‐21 did not significantly change the expression level of NKILA. Overexpression of NKILA repressed the proliferation and promoted the apoptosis of CSCC cells, while miRNA‐21 showed opposite functions. In addition, miRNA‐21 mimic transfection reduced the effects of NKILA on CSCC cells. Collectively, lncRNA NKILA could repress the proliferation and promote the apoptosis of CSCC cells by downregulating miRNA‐21.
Identification of potential miRNA biomarkers for traumatic osteonecrosis of femoral head
Authors: Liu Guan‐Zhi , Chen Chen , Kong Ning , Tian Run , Li Yi‐Yang , Li Zhe , Wang Kun‐Zheng , Yang Pei 
Published: January 2020

AbstractTraumatic osteonecrosis of femoral head (TONFH) is a common orthopedic disease caused by physical injury in hip. However, the unclear pathogenesis mechanism of TONFH and lacking of simple noninvasive early diagnosis method cause the necessity of hip replacement for most patients with TONFH. In this study, we aimed to identify circulating microRNAs (miRNAs) by integrated bioinformatics analyses as potential biomarker of TONFH. mRNA expression profiles were downloaded from the Gene Expression Omnibus database. Then we combined two miRNA screen methods: Weighted gene co‐expression network analysis and fold change based differentially expressed miRNAs analysis. As a result, we identified 14 key miRNAs as potential biomarkers for TONFH. Besides, 302 target genes of these miRNAs were obtained and the miRNA–mRNA interaction network was constructed. Furthermore, the results of Kyoto Encyclopedia of Gene and Genome pathway analysis, Gene Ontology function analysis, protein–protein interaction (PPI) network analysis and PPI network module analysis showed close correlation between these 14 key miRNAs and TONFH. Then we established receiver operating characteristic curves and identified 6‐miRNA signature with highly diagnosis value including miR‐93‐5p (area under the curve [AUC] = 0.93), miR‐1324 (AUC = 0.92), miR‐4666a‐3p (AUC = 0.92), miR‐5011‐3p (AUC = 0.92), and miR‐320a (AUC = 0.89), miR‐185‐5p (AUC = 0.89). Finally, the results of quantitative real‐time polymerase chain reaction confirmed the significantly higher expression of miR‐93‐5p and miR‐320a in the serum of patients with ONFH. These circulating miRNAs could serve as candidate early diagnosis markers and potential treatment targets of TONFH.
Facing the surgeon's nightmare: Incidence and management of postoperative pancreatic fistulas grade C after pancreaticoduodenectomy based on the updated definition of the International Study Group of Pancreatic Surgery (ISGPS)
Authors: Luu Andreas Minh , Krasemann Lukas , Fahlbusch Tim , Belyaev Orlin , Janot‐Matuschek Monika , Uhl Waldemar , Braumann Chris 
Published: January 2020

AbstractBackgroundPostoperative pancreatic fistulas (POPF) grade C represent a rare but feared complication following pancreaticoduodenectomy (PD). They can contribute significantly to postoperative morbidity and mortality.MethodsWe performed a retrospective chart review for all patients who had undergone pancreatic head resection between 2007 and 2016 to identify those who suffered from POPF grade C according to the updated definition of the International Study Group of Pancreatic Surgery (ISGPS).ResultsA total of 722 patients underwent PD. Twenty‐three patients (3.19%) developed a POPF grade C. Cardiovascular diseases, soft pancreatic texture and main pancreatic duct diameter were identified as risk factors (P < .05). Reoperation was necessary in all affected patients on postoperative day 12 ± 9 on average. Mortality was significantly associated with POPF grade C (P < .05) being present in 39.1% (9/23).ConclusionsPOPF grade C after PD remains a serious complication with a high level of morbidity and mortality. Surgical treatment is the sole curative therapy and thus the treatment of choice.
Liver function test abnormalities in a longitudinal cohort of Thai individuals treated since acute HIV infection
Authors: Peluso Michael J , Colby Donn J , Pinyakorn Suteeraporn , Ubolyam Sasiwimol , Intasan Jintana , Trichavaroj Rapee , Chomchey Nitiya , Prueksakaew Peeriya , Slike Bonnie M , Krebs Shelly J , Jian Ningbo , Robb Merlin L , Phanuphak Praphan , Phanuphak Nittaya , Spudich Serena , Ananworanich Jintanat , Kroon Eugène ,   on behalf of the SEARCH010/RV254 Study Group
Published: January 2020

AbstractIntroductionLiver disease is a common cause of non‐AIDS morbidity and mortality in people living with HIV (PLHIV), but the prevalence and significance of liver function test (LFT) abnormalities in early HIV infection is unknown. This study aimed to characterize LFTs in a large cohort of participants with acute HIV infection initiating immediate antiretroviral therapy (ART) and examine the association between LFTs and biomarkers of HIV infection and inflammation.MethodsWe measured LFTs at the time of HIV diagnosis and at 4, 12, 24 and 48 weeks after ART initiation in 426 Thai individuals with acute HIV infection from 2009 to 2018. A subset of individuals had data available at 96 and 144 weeks. We excluded individuals with concomitant viral hepatitis. Alanine aminotransferase (ALT) was the primary outcome of interest; values greater than 1.25 times the upper limit of normal were considered elevated. Analyses utilized descriptive statistics, non‐parametric tests and multivariate logistic regression.ResultsSixty‐six of the 426 individuals (15.5%) had abnormal baseline ALT levels; the majority (43/66, 65.5%) had Grade 1 elevations. Elevated baseline ALT correlated with Fiebig stages III to V (p = 0.001) and baseline HIV RNA >6 log10 copies/mL (p = 0.012). Baseline elevations resolved by 48 weeks on ART in 59 of the 66 individuals (89%). ALT elevations at 24 and 48 weeks correlated with Fiebig stages I to II at diagnosis (p < 0.001), baseline plasma HIV RNA levels <6 log10 copies/mL (p < 0.001), abnormal baseline ALT (p < 0.001), baseline CD4 >350 cells/μL (p = 0.03) and older age (p = 0.03). Individuals initiating efavirenz‐based regimens were more likely to have elevated ALT levels at 48 weeks compared with those on non‐efavirenz‐based regimens (p = 0.003).ConclusionsOne in six people with acute HIV infection have elevated LFTs. Clinical outcomes with ART started in acute HIV are generally good, with resolution of ALT elevations within 48 weeks on ART in most cases. These results suggest a multifactorial model for hepatic injury involving a combination of HIV‐associated and ART‐associated processes, which may change over time.
Transcriptional regulation of neutrophil differentiation and function during inflammation
Authors: Ai Zhichao , Udalova Irina A. 
Published: January 2020

AbstractNeutrophils are the most abundant leukocytes in innate immunity where they elicit powerful effector functions to eliminate invading pathogens and modulate the adaptive as well as the innate immune response. Neutrophil function must be tightly regulated during inflammation and infection to avoid additional tissue damage. Increasing evidence suggests that transcription factors (TFs) function as key regulators to modulate transcriptional output, thereby controlling cell fate decision and the inflammatory responses. However, the molecular mechanisms underlying neutrophil differentiation and function during inflammation remain largely uncharacterized. Here, we provide a comprehensive overview of TFs known to be crucial for neutrophil maturation and in the signaling pathways that control neutrophil differentiation and activation. We also outline how emerging genomic and single-cell technologies may facilitate further discovery of neutrophil transcriptional regulators.
Time perspective balance and team adaptation in dynamic task contexts
Authors: Waller Mary J. , Franklin Ashley E. , Parcher Dana B. 
Published: January 2020

SummaryThe concept of time perspective balance has attracted increased attention from scholars in the past decade, reflected in published evidence suggesting positive outcomes ranging from enhanced mood to life satisfaction for those individuals possessing balance among their past, present, and future time perspectives, and assumedly able to shift their time perspective to match situational demands. In this paper, we consider the notion of time perspective balance in an organizational setting within which much consequential adaptation often occurs—the team environment—and explore different configurations of time perspective balance in teams facing dynamic task contexts. Drawing from work on situational awareness, we first consider the mechanism by which time perspective balance likely influences individual adaptation in dynamic task‐focused situations. Next, we postulate what types of team configurations—ones with more balanced time perspective uniformity or ones with more time perspective variety—might be more appropriate in dynamic contexts given key team conditions. We illustrate our analysis with examples from healthcare team settings and offer ideas for future research.
A male infant with Xq22.2q22.3 duplication containing PLP1 and MID2
Authors: Chanchani Swati R. , Xie Hongyan , Sekhon Gurbax , Melikishvili Ana M. , Moyer Harasink Sue , Pall Harpreet , Giampietro Philip F. 
Published: January 2020

AbstractBackgroundThe Xq22.2 q23 is a complex genomic region which includes the genes MID2 and PLP1 associated with FG syndrome 5 and Pelizaeus–Merzbacher disease, respectively. There is limited information regarding the clinical outcomes observed in patients with deletions within this region.MethodsWe report on a male infant with intrauterine growth retardation (IUGR) who developed head titubation and spasticity during his postnatal hospital course.ResultsChromosome microarray revealed a 6.7 Mb interstitial duplication of Xq22.2q22.3. Fluorescence in situ hybridization showed that the patient's mother also possessed the identical duplication in the Xq22.3q22.3 region. Among the 34 OMIM genes in this interval, the duplication of the PLP1 (OMIM# 300401) and MID2 (OMIM# 300204) appears to be the most significant contributors to the patient's clinical features. Mutations and duplications of PLP1 are associated with X‐linked recessive Pelizaeus–Merzbacher disease (PMD). A single case of a Xq22.3 duplication including the MID2 has been reported in boy with features of FG syndrome. However, our patient's clinical features are not consistent with the FG syndrome phenotype.ConclusionOur patient's clinical features appear to be influenced by the PLP1 duplication but the clinical effect of other dosage sensitive genes influencing brain development cannot be ruled out.
Compound heterozygous mutations in FBN1 in a large family with Marfan syndrome
Authors: McInerney‐Leo Aideen M. , West Jennifer , Wheeler Lawrie , Leo Paul J. , Summers Kim M. , Anderson Lisa , Brown Matthew A. , West Malcolm , Duncan Emma L. 
Published: January 2020

AbstractBackgroundMarfan syndrome (MFS) is a dominant monogenic disorder caused by mutations in fibrillin 1 (FBN1). Rarely, compound heterozygosity for FBN1 mutations has been described.MethodsA large kindred with MFS was assessed clinically over decades, and genetically using exome and/or Sanger sequencing.ResultsA previously identified FBN1 missense variant (p.Tyr754Cys) was confirmed in all subjects with MFS. An additional variant (p.Met2273Thr), previously associated with incomplete MFS, was identified in three siblings. These three compound heterozygous individuals had aortic dilatation at early age (all <30 years): one also had cerebral and ocular aneurysms; and one, who had undergone surgical repair aged 18 years, died from aortic dissection at 31 years. In contrast, their heterozygous father (p.Tyr754Cys) with MFS died at 57 years (myocardial infarction) without requiring surgical intervention and one heterozygous (p.Tyr754Cys) sibling has aortic dilatation presenting >40 years but not requiring surgical intervention. Another heterozygous (p.Tyr754Cys) sibling did require aortic root repair (28 years). The heterozygous (p.Met2273Thr) mother had aortic dilatation diagnosed at age 68 years but has not required surgical repair.ConclusionAlthough compound heterozygosity or homozygosity is rare in MFS, it should be considered when there is an unusually severe phenotype in a subset of family members.
Technical Note: Radiotherapy dose characterization of gel dosimetry using shear wave elasticity imaging
Authors: Xie Wei‐Huan , Su Chun‐Ting , Kao Yu‐Chieh Jill , Chang Tung‐Hao , Chang Yuan‐Jen , Yao Chun‐Hsu , Hsieh Bao‐Yu 
Published: January 2020

PurposeRadiotherapy is an effective treatment for many types of cancer in clinical settings. Gel dosimetry has the potential to record three‐dimensional (3D) dose distribution compared to a conventional ion chamber. As the elasticity of the gel is altered after irradiation due to gel polymerization, we aim to measure the dose recorded in gel dosimetry with ultrasonic shear wave elasticity imaging (SWEI), a nondestructive and quantitative elasticity imaging tool.MethodsIn this study, a cylindrical N‐isopropylacrylamide (NIPAM) polymer gel with a diameter of 10 cm and a height of 10 cm and with cellulose as an ultrasonic scatterer was irradiated by a linear accelerator with the irradiation parameters of 6 MV x‐ray, dose rate of 100 cGy/min and field size of 10 20 mm2. The six gel phantoms were irradiated with the dose of 0, 1, 3, 5, 8, or 10 Gy. The gel phantoms were measured with SWEI at 24, 36, and 48 h after x‐ray irradiation. The two‐dimensional (2D) shear wave velocity and Young’s modulus maps corresponding to x‐ray dose distribution were reconstructed following a time‐of‐flight reconstruction from a set of time‐series displacement maps. The spatial resolution of the reconstructed SWEI image is ~1 mm.ResultsOur results show that the elastic modulus increases linearly as irradiation dose increases (R2 = 0.94 at 24 h, R2 = 0.98 at 36 h, R2 = 0.98 at 48 h), suggesting that the gel elasticity is highly associated with x‐ray irradiation dose at 36 h post irradiation, and the dose resolution was 0.66 kPa/Gy. From the 3D elastic modulus maps, the dose distribution along the depth and lateral direction can be reflected in the NIPAM gel dosimetry using SWEI as well.ConclusionsIn this study, the irradiated NIPAM gel phantom was quantitatively measured with SWEI for the first time to read the dose distribution recorded in the gel dosimetry. The results suggest that the gel elasticity is highly associated with x‐ray irradiation dose. In the future, 2D/or 3D dose distribution from intensity modulated radiotherapy (IMRT) or other potential particle radiotherapy will be measured and reconstructed with SWEI and compared with the dose map from a treatment planning system (TPS) in the clinic.
Quality measures in electrodiagnosis: Carpal tunnel syndrome—An AANEM Quality Measure Set
Authors: Zivkovic Sasha , Gruener Gregory , Arnold Michele , Winter Carrie , Nuckols Teryl , Narayanaswami Pushpa ,   and the Quality Improvement Committee of the American Association of Neuromuscular & Electrodiagnostic Medicine
Published: January 2020

AbstractCarpal tunnel syndrome (CTS) is a common neuromuscular condition and a major cause of work‐related disability. As healthcare in the United States transitions toward a value‐based system from fee‐for‐service, quality measures assume importance in the evaluation of care provided. This report from the American Association of Neuromuscular & Electrodiagnostic Medicine Quality Improvement Committee provides an introduction to quality measures and outlines a quality measurement set for the electrodiagnosis of CTS. The measures attempt to standardize technical requirements for electrodiagnostic (EDX) studies of CTS, the criteria for diagnosing median neuropathy at the wrist and assessing its severity, and the role of operative EDX testing. The assumption is that implementation of these measures will improve the accuracy of CTS diagnosis when EDX is performed, help exclude mimics, and, therefore, improve care of patients with CTS with the ultimate goal of improving outcomes. Postimplementation assessment of outcomes will refine these measures.
Burst‐modulated wide‐pulse neuromuscular electrical stimulation enhances H‐reflex recruitment in rats
Authors: Qu Wen , Hou Wensheng , Zhao Yun , Shu Bin , Chen Lin , Zheng Xiaolin , Wang Xing , Wu Xiaoying 
Published: January 2020

AbstractIntroductionIn this study we investigated whether burst‐modulated wide‐pulse neuromuscular electrical stimulation (NMES) can improve the H‐reflex and activation efficiency of sensory fibers.MethodsNMES‐induced electromyography (EMG) was recorded from hindpaw plantar muscles in 11 anesthetized rats. A burst‐modulated wide pulse (mWP) with three carrier frequencies (2 kHz, 5 kHz, and 10 kHz) and a continuous wide‐pulse (WP) were delivered to the tibial nerve of each rat. The evoked Hoffman (H)‐reflexes were measured to evaluate nerve activation efficiency using the H‐reflex recruitment curve (HRC).ResultsRelative to WP simulation, mWP stimulation required less electrical charge to excite sensory fibers and improved the H‐reflex recruitment. Greater electrical charge and smaller recruitment gains were obtained with increased carrier frequency of mWP.DiscussionmWP NMES can improve stimulation efficiency and improve recruitment of sensory fibers on tibial nerve stimulation, which may help to optimize NMES stimulus parameters.