bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Strategi Pemasaran Pada PT. Central International Education
Authors: Pitri Tri Veny , Gunarto Muji 
Published: October 2020

The aim of this study was to decide the marketing strategy of PT. Central International Education by using SWOT analysis ,so it could be conclude that there were some internal factors that had stength such as cleanliness, a large parking area, good and reliable services, and products with good quality. meanwhile, there were some weaknesses such complains handling which was still not maximum, less promotion strategies and employees coming late to the office. some external factors were marketing opportunities, target market, product quality and good relationship with customers. there were also some threats such as business competitor s, government rule and new competitors. some strategies that can be used in future are giving good and quick responses to customers, improving promotion strategies, improving company services to ensure the cumtomers, maximizing promotion and advertisments to attract the customers and extending the market regions.
Pengaruh Pelatihan dan Pengembangan SDM terhadap Prestasi Kerja pada PT Tanjung Enim Lestari Pulp and Paper Unit Chemical Plant
Authors: Pratama M. Rizky Pippo 
Published: October 2020

Penelitian ini bertujuan untuk mengetahui pengaruh pelatihan dan pengembangan sumber daya manusia terhadap prestasi kerja pada PT Tanjung Enim Lestari Unit Chemical Plant. Penelitian ini menggunakan metode penelitian kuantitatif. Penelitian ini melibatkan sebanyak 33 karyawan pada PT Tanjung Enim Lestari Unit Chemical Plant. Sumber data diperoleh melalui data primer dan data sekunder dengan teknik pengumpulan data yang dilakukan melalui observasi dan penyebaran kuesioner kepada seluruh anggota responden. Berdasarkan hasil pengujian hipotesis dengan ketentuan jika thitung > ttabel maka hipotesis diterima. Berdasarkan hasil penelitian menggunakan SPSS V.19 dapat disimpulkan bahwa terdapat pengaruh yang signifikan antara pelatihan dan pengembaran SDM terhadap prestasi kerja secara parsial. Uji F menjelaskan bahwa terdapat pengaruh yang signifikan antara variabel pelatihan dan pengembangan sdm terhadap prestasi. Hasil uji koefisien determinasi (R2) menunjukan Adjusted R Square 0,578. Hal ini menjelaskan bahwa 57,8% variasi variabel prestasi kerja dapat dijelaskan oleh variabel pelatihan dan pengembangan sdm, sisanya 42,2% dijelaskan oleh variabel lain diluar penelitian.
Risperidone-induced bruise-like rash in a child
Authors: Ekinci Ozalp , Gunes Serkan 
Published: October 2020

ABSTRACT
Adverse cutaneous reactions are rarely seen with antipsychotics. Exanthematous eruptions, skin pigmentation changes, photosensitivity, urticaria, and pruritus have been previously reported. We report a bruise-like rash in a 4-year-old boy with risperidone use. The rash disappeared on discontinuation and then reappeared after re-initiating the medication. Clinicians should be aware of a bruise-like skin rash as a rare adverse effect of risperidone. This is especially important for pediatric cases where physical abuse may be suspected.

SIMILAR CASES PUBLISHED:
None.
Bont en blauw: strafbaar en straffeloos geweldgebruik door de politie
Authors: Dolman M.M. (Menno) 
Published: October 2020

Bont en blauw: strafbaar en straffeloos geweldgebruik door de politie
Van de politie wordt in beginsel verlangd dat zij zich vreedzaam van haar taken kwijt. Bij de uitoefening daarvan kan zij echter geconfronteerd worden met personen die deze frustreren, en genoopt worden geweld te gebruiken. Dat levert veelal een strafbaar feit op, dus rijst de vraag hoe recht gedaan moet worden aan de omstandigheid dat geweld gebruikt werd door een overheidsfunctionaris, onder moeilijke omstandigheden. De Wet geweldsaanwending opsporingsambtenaar markeert de keuze voor een nieuw perspectief op politiegeweld.
Empirical Study of Family Conflicts as a Factor of Emotional Burnout of a Woman
Authors: Biletska Iryna O. , Kotlova Liudmyla O. , Kotlovyi Serhii A. , Beheza Liudmyla Ye. , Kulzhabayeva Lyazzat S. 
Published: October 2020

Objective: Conflict issues have always been relevant to any society, but in Ukraine, at all stages of its development, conflicts had not just a noticeable place, but also influenced its history.
Background: Conflicts, of course, adversely affect these processes, because a woman spends most of her life in the family and, of course, the climate inside the family affects the emotional state of all its members.
Method: To study the relationship between the level of conflict in the family and the emotional burnout of a woman, we used the following research methods: empirical – methodologies of Y. Aleshina, L. Hoffmann, E. Dubovskaya "The nature of the interaction of the matrimony in conflict situations” and V. Boiko “Diagnostics of emotional burnout”, statistical – Pearson’s linear correlation coefficient.
Results: The study involved 80 participants. The study also determined the relationship between the evaluation of the work-life balance and organizational parameters. As a result of the study, we determined that the syndrome most characteristic of women is exhaustion, at the average level – stress, at a low level, is a resistance.
Conclusion: The study suggests that in families with a high level of conflict, there is emotional exhaustion in women.
A basilosaurid archaeocete (Cetacea, Pelagiceti) from the Late Eocene of Oregon, USA
Authors: Uhen Mark D. , Taylor David 
Published: October 2020

BackgroundBasilosaurid archaeocetes are known from the Late Eocene of virtually all coastlines bearing coeval marine rocks except the North Pacific Basin, until now. Here we report on three consecutive posterior thoracic vertebrae of a large, basilosaurid archaeocete from a Late Eocene horizon in the Keasey Formation in Oregon.MethodsThese vertebrae were morphologically and morphometrically compared to other vertebrae of similar age from around the world.ResultsThe specimens were determined to be different from all currently named species of fossil cetacean, but most similar to those found in the Gulf Coast region of North America. These vertebrae represent the first confirmed specimen of a Late Eocene basilosaurid from the North Pacific. These and other basilosaurids known only from vertebrae are reviewed here in the context of Late Eocene paleoceanography and cetacean evolution.
A novel dual MEK/PDK1 inhibitor 9za retards the cell cycle at G0/G1 phase and induces mitochondrial apoptosis in non-small cell lung cancer cells
Authors: Liu Rangru , Yu Zutao , Chen Zhuo , Liu Danqi , Huang Fengying , Li Qianbin , Hu Gaoyun , Yi Xinan , Li Xi , Zhou Honghao , Liu Zhaoqian 
Published: October 2020

Background
A novel dual MEK/PDK1 inhibitor named 9za has been synthesized by our research team. Preliminary study showed that 9za possessed potent cytotoxicity and proapoptosis in non-small cell lung cancer (NSCLC) cells. Nevertheless, the precise underlying mechanism is vague.

Methods
In this work, we adopted the MTT assay, the Cell Cycle Detection Kit, and the JC-1 staining assay to detect the cell viability, the cell cycle distribution and the mitochondrial membrane potential (MMP), respectively. Cell apoptosis was measured by the morphology observation under a light microscope, Annexin V-FITC/propidium iodide (PI) apoptosis detection and the colorimetric TUNEL assay. Western blot was used to monitor the cell cycle-, apoptosis-related proteins and relevant proteins involved in the signaling pathways.

Results
The MTT assay demonstrated that 9za sharply decreased the viability of NSCLC cells. Cell cycle analysis revealed that low concentrations of 9za arrested the cell cycle at the G0/G1 phase , which was further confirmed by the decreased levels of Cyclin D1, cyclin-dependent kinase 4 (CDK4) and cyclin-dependent kinase 6 (CDK6). Additionally, morphological observations, Annexin V-FITC/propidium iodide (PI) apoptosis analysis and TUNEL assays indicated that high concentrations of 9za induced cell apoptosis. Furthermore, the JC-1 staining assay revealed that the mitochondrial membrane potential was downregulated following 9za exposure. Western blot also showed that 9za markedly decreased the expression levels of total Bcl-2, Cytochrome C in the mitochondria and BCL2 associated X (BAX) in the cytoplasm. However, the levels of BAX in the mitochondria, Cytochrome C in the cytoplasm, active caspase-9, active caspase-3 and cleaved–PARP showed the opposite changes. Moreover, the dose-dependent decreased phosphorylation levels of PDK1, protein kinase B (Akt), MEK and extracellular signal regulated kinase 1/2 (ERK1/2) after 9za treatment verified that 9za was indeed a dual MEK/PDK1 inhibitor, as we expected. Compared with a single MEK inhibitor PD0325901 or a single PDK1 inhibitor BX517, the dual MEK/PDK1 inhibitor 9za could strengthen the cytotoxic and proapoptotic effect, indicating that the double blocking of the MEK and PDK1 signaling pathways plays stronger cell growth inhibition and apoptosis induction roles than the single blocking of the MEK or PDK1 signaling pathway in NSCLC cells. Our work elucidated the molecular mechanisms for 9za as a novel drug candidate against NSCLC.
The Influence of Tax Education on Obeying Tax Liability: A Statistical Methods and Results
Authors: Shamana Tizazu Toma , Alito Woldeselassie Azige 
Published: October 2020

Backgrounds: In Ethiopia, taxpayers are categorized as small, medium or large depending on their business turnover or levels of income. Irrespective of one's category, taxpayers in Ethiopia, particularly Wolaita Sodo town are required to comply with VAT, TOT, Income Tax, Withholding Taxes and Customs duties in equal measure. Taxpayers will readily accept any new system introduced if they have ample knowledge to understand the system. Thus, education programs organized by custom and duty authority or public education institutions are required to enhance taxpayers' ability to understand the importance of tax on country's economic development and to increase their confidence in fulfilling their responsibilities as taxpayers. By considering the above issues, the researcher interested to investigate the influence of tax education on tax compliance attitude of taxpayers by conducting an experiment on the taxpayer in Wolaita Sodo town. The general objective of the study was to investigate the influence of tax education on tax compliance in Wolaita Sodo town.
Methods: The target population for the survey study was actual taxpayers who are subject for business income tax. Only unincorporated business taxpayers in Wolaiata Sodo town are used as participants in the survey study. The target total population is 11,278 business income taxpayers as of July 2017 which is categorized under A, B and C. Only 160 taxpayers were selected by using simple random sampling from Wolaiata Sodo town. Questions regarding employment income, business income, turn over tax, and excise and value-added taxes are asked. Respondents are also asked to state whether the direct cost of producing the income, such as the direct cost of manufacturing, purchasing and selling costs shall be deductible from gross income in calculating taxable business income. Before and after the experiment (tax education) respondents were asked to check whether they know basic taxation rules. And their marks scored for the 7 basic questions after and before tax education out of 50 marks are recorded.
Results: Majority of the respondents after attending the tax course scored high value regarding the tax knowledge. There is a great difference between the tax compliance attitude of these respondents before and after attending the tax course. Before attending the tax course, majority of respondents showed the plan of not complying with tax laws. But after attending the tax course, the majority of the respondents proves the identification of taxable and non-taxable income types. Generally, it resulted that the tax knowledge of respondents is improved after attending the tax course.
Self‐Deposition of 2D Molybdenum Sulfides on Liquid Metals
Authors: Wang Yifang , Mayyas Mohannad , Yang Jiong , Tang Jianbo , Ghasemian Mohammad B. , Han Jialuo , Elbourne Aaron , Daeneke Torben , Kaner Richard B. , Kalantar‐Zadeh Kourosh 
Published: October 2020

Abstract2D transition metal dichalcogenides (TMDs) play increasingly significant roles in research and future optoelectronics. However, the large‐scale deposition of 2D TMDs remains challenging due to sparse nucleation and substrate dependency. Liquid metals can offer effective solutions to meet these challenges due to their reactive, non‐polarized, and templating properties. Here, self‐deposition of 2D molybdenum sulfide is shown by introducing a molybdenum precursor onto the surface of a eutectic alloy of gallium and indium (EGaIn). EGaIn serves as an ultra‐smooth template and reducing agent for the precursor to form large‐scale planar molybdenum sulfides, which is transferrable to any substrate. The molybdenum sulfides form spontaneously on the surface of EGaIn, which has a sufficient potential to drive the cathodic reactions of the deposition process. A highly crystalline 2H‐MoS2 is obtained after a final annealing step. This work demonstrates a fundamentally new capability for the formation of large‐scale 2D TMDs.
Squeezing a Prism into a Surface: Emulating Bulk Optics with Achromatic Metasurfaces
Authors: Tsilipakos Odysseas , Kafesaki Maria , Economou Eleftherios N. , Soukoulis Costas M. , Koschny Thomas 
Published: October 2020

AbstractMetasurfaces promise to replace bulky prisms and lenses with 2D surfaces, revolutionizing wavefront control with technologically significant advantages in size, weight, and planar fabrication. However, conventional implementations suffer from large chromatic aberrations and cannot sustain performance over practical bandwidths of real‐world signals because of the limited phase modulation margin available in a surface. How can an infinitely thin surface generate the arbitrarily large, broadband phase delay that bulk phase accumulation can provide? Here, equivalence between bulk optics and certain multiresonant metasurfaces is demonstrated, where phase delay arises from trains of multiple resonances in the effective sheet conductivities of the surface itself instead of accumulation of propagation phase. The fundamentally required electromagnetic surface conductivities of a purely achromatic metasurface are derived and general design rules for arbitrarily broadband beam steering and lensing are obtained. Both operation in transmission and reflection can be achieved in a unified way by proper alignment of the resonances, enabling 360° directionality. The arbitrary spectral bandwidth, dual reflection/transmission operation, and complete dispensability of propagation phase constitute a major advance in the state of the art of achromatic metasurfaces for wavefront manipulation.
Near‐Infrared Fluorescence from Silicon‐ and Nickel‐Based Color Centers in High‐Pressure High‐Temperature Diamond Micro‐ and Nanoparticles
Authors: Shames Alexander I. , Dalis Adamos , Greentree Andrew D. , Gibson Brant C. , Abe Hiroshi , Ohshima Takeshi , Shenderova Olga , Zaitsev Alexander , Reineck Philipp 
Published: October 2020

AbstractFluorescent color centers in diamond are invaluable room temperature quantum systems in fundamental scientific studies and vital for many emerging applications from inertial navigation to quantum sensing in biology. Yet, controlled production of specific color centers in synthetic diamond at scale remains challenging. Characteristics of silicon‐ and nickel‐based defects with strong fluorescence in the 700–950 nm spectral region formed in Si‐ and Ni‐doped diamond, created via high‐pressure high‐temperature synthesis in commercial quantities without irradiation, are reported. Using electron paramagnetic resonance spectroscopy and fluorescence spectroscopy, the presence of defects including the negatively charged silicon‐vacancy (SiV−), silicon‐boron (SiB) and positively charged substitutional nickel center (Nis+) in micrometer‐sized particles is identified and quantified. The color centers’ optical properties are investigated via time‐resolved and steady‐state fluorescence spectroscopy below 10 K and at room temperature. In ensemble measurements, the particles show no detectable signals from nitrogen‐vacancy (NV−) defects. The particles’ relative fluorescence brightness is quantified and compared to particles containing ≈1 ppm NV− centers. It is demonstrated that the Nis+ center fluorescence characteristics are preserved in 50 nm nanoparticles. The work paves the way for the use of fluorescent nanodiamonds in the first near‐infrared biological window between 700 nm and 950 nm in biomedical applications.
Copper‐Catalyzed Synthesis of α‐Trifluoromethylacrylates from Trifluoroborylacrylates via Stereoretentive Radical Trifluoromethylation
Authors: Jos Swetha , Santos Webster L. 
Published: October 2020

AbstractWe report the synthesis of α‐trifluoromethylacrylates from α‐trifluoroborylacrylates via a stereoretentive radical trifluoromethylation with inexpensive reagents NaSO2CF3 and TBHP at room temperature. Under these conditions, a wide substrate scope afforded the (E)‐diastereomer exclusively in moderate to good yield. The utility of the reaction products is demonstrated in the synthesis of phenyl‐4H‐pyran, a potent and selective class of IKCa channel blockers.magnified image
Formal Ring Contraction of Cyclic N‐Sulfonamides via C−N Bond Cleavage and α‐Amination by Oxidation of Halides
Authors: Nishiguchi Yuna , Tomizuka Akihiko , Moriyama Katsuhiko 
Published: October 2020

AbstractAn oxidative C−N bond cleavage reaction of substituted cyclic sulfonamides that proceeds via oxidation of bromide ion in hydrogen bromide solution was developed to furnish N‐sulfonamide‐protected acyclic amino ketones in high yields. The subsequent α‐amination of the amino ketones via the oxidation of iodide in tetrabutylammonium iodide provided 2‐acyl cyclic sulfonamides in good yields. The combination of these transformations involving the oxidation of halides resulted in a formal ring contraction of substituted cyclic amides.magnified image
Preventing thrombosis in a COVID‐19 patient by combined therapy with nafamostat and heparin during extracorporeal membrane oxygenation
Authors: Doi Shunichi , Akashi Yoshihiro J. , Takita Mumon , Yoshida Hideki , Morikawa Daiki , Ishibashi Yuki , Higuma Takumi , Fujitani Shigeki 
Published: October 2020

BackgroundPreventing thrombosis in extracorporeal membrane oxygenation (ECMO) can be life‐saving in cases of coronavirus disease (COVID‐19); however, circuit thrombosis is a complication. This report describes a COVID‐19 patient treated with nafamostat and heparin to prevent circuit thrombosis during ECMO support.Case presentationA 63‐year‐old man was transferred to our hospital with respiratory failure due to COVID‐19 pneumonia. He was provided venous‐venous ECMO to maintain oxygenation. During ECMO support, occlusive circuit thrombosis developed despite systemic anticoagulation therapy with heparin. He was subsequently given combination therapy with nafamostat and heparin. Although the combination therapy could prevent circuit thrombosis, it was converted to heparin monotherapy because of hyperkalemia and hemothorax. After tracheostomy and a gradual improvement in oxygenation, ECMO was discontinued. He was transferred to another hospital for further rehabilitation.ConclusionCombination therapy with nafamostat and heparin can prevent circuit thrombosis during ECMO. However, bleeding can still develop with this combination therapy during ECMO.
Rational Assembly of Metallophilic Gold(I)–Lead(II) and Gold(I)–Gold(I) Puzzle Pieces
Authors: López‐de‐Luzuriaga José M. , Monge Miguel , Moreno Sonia , Olmos M. Elena , Rodríguez‐Castillo María 
Published: October 2020

AbstractThe assembly of two different building blocks, [{Au(C6F5)2}{PbCl(terpy)}] (terpy=2,2′:6′:2′′‐terpyridine) and [{Au(C6F5)2}2{Pb(terpy)}]n, acting as terminal or central pieces, respectively, gives rise to a decanuclear complex built via metallophilic and π‐stacking interactions in which the number of AuI⋅⋅⋅AuI and AuI⋅⋅⋅PbII contacts is finely controlled.
Controlled Dimerization and Bonding Scheme of Icosahedral M@Au12 (M=Pd, Pt) Superatoms
Authors: Ito Emi , Takano Shinjiro , Nakamura Toshikazu , Tsukuda Tatsuya 
Published: October 2020

AbstractTargeted syntheses of MM′Au36(PET)24 (M, M′=Pd, Pt; PET=SC2H4Ph) were achieved by hydride‐mediated fusion reactions between [MAu8(PPh3)8]2+ and [M′Au24(PET)18]−. Single‐crystal X‐ray diffraction analysis indicated that the products have bi‐icosahedral MM′Au21 cores composed of M@Au12 and M′@Au12 superatoms. Although the MM′Au21 superatomic molecules correspond to O2 in terms of the number of valence electrons (12 e), the distances between the icosahedrons were larger than that in the bi‐icosahedral Au23 core of Au38(PET)24 corresponding to F2 and the spin state was singlet. These counterintuitive results were explained by a “bent bonding model” based on tilted (non‐orthogonal) bonding interaction between the 1P superatomic orbitals of M@Au12 and M′@Au12 superatoms.
Controlling the Surface Oxidation of Cu Nanowires Improves Their Catalytic Selectivity and Stability toward C2+ Products in CO2 Reduction
Authors: Lyu Zhiheng , Zhu Shangqian , Xie Minghao , Zhang Yu , Chen Zitao , Chen Ruhui , Tian Mengkun , Chi Miaofang , Shao Minhua , Xia Younan 
Published: October 2020

AbstractCopper nanostructures are promising catalysts for the electrochemical reduction of CO2 because of their unique ability to produce a large proportion of multi‐carbon products. Despite great progress, the selectivity and stability of such catalysts still need to be substantially improved. Here, we demonstrate that controlling the surface oxidation of Cu nanowires (CuNWs) can greatly improve their C2+ selectivity and stability. Specifically, we achieve a faradaic efficiency as high as 57.7 and 52.0 % for ethylene when the CuNWs are oxidized by the O2 from air and aqueous H2O2, respectively, and both of them show hydrogen selectivity below 12 %. The high yields of C2+ products can be mainly attributed to the increase in surface roughness and the generation of defects and cavities during the electrochemical reduction of the oxide layer. Our results also indicate that the formation of a relatively thick, smooth oxide sheath can improve the catalytic stability by mitigating the fragmentation issue.
Asymmetric Allylation by Chiral Organocatalyst‐Promoted Formal Hetero‐Ene Reactions of Alkylgold Intermediates
Authors: Dong Guizhi , Bao Ming , Xie Xiongda , Jia Shikun , Hu Wenhao , Xu Xinfang 
Published: October 2020

AbstractAn unprecedented catalytic asymmetric allylation of isatins and isatin‐derived ketimines is reported enabled by a gold and chiral organocatalyst cooperative catalysis strategy. This method offers expeditious access to chiral 2,5‐disubsituted alkylideneoxazolines containing vicinal stereogenic centers, mainly in optically pure form, and which are otherwise impossible to access. Mechanistic evidence reveals the presence of an alkylgold intermediate, and an X‐ray crystal structure of the allylgold species illuminates its unique stability and reactivity. An asymmetric formal hetero‐ene reaction of this gold intermediate, involving a dearomatization process, is enabled with assistance of a quinine‐derived squaramide catalyst. This novel discovery extends the synthetic applications of gold complexes and the versatility of gold catalysis.