bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reconciling Ground Motions and Stress Drops for Induced Earthquakes in the Western Canada Sedimentary Basin
Authors: Holmgren Joanna M. , Atkinson Gail M. , Ghofrani Hadi 
Published: March 2020

ABSTRACTA regional ground-motion prediction equation (GMPE) is defined for earthquakes in the western Canada sedimentary basin. The stress parameter model that is input to the GMPE, which controls high-frequency amplitudes, is developed based on an empirical Green’s function (EGF) study in the same region (Holmgren et al., 2019). The GMPE is developed using the generic GMPE approach of Yenier and Atkinson (2015a,b); regional parameters, including attenuation and site response, are calibrated using a database of response spectra. The ground-motion database comprises 726 records from 92 earthquakes with magnitudes 2.3–4.4, at distances to 200 km; most events are believed to be related to hydraulic fracturing. To investigate discrepancies between the values of GMPE stress parameter and EGF stress drop for individual earthquakes, stress parameters are computed for each event by fitting the GMPE to observed response spectra. There is a large scatter in the EGF versus GMPE stress estimates, even though the GMPE estimates were implicitly calibrated to equal the EGF values on average. The discrepancies can be attributed to two methodological factors. First, the EGF approach removes the site and path terms through spectral division, whereas the GMPE approach relies on an average regional model as determined from regression of the source and path attenuation. The use of an average regional model results in greater uncertainty, in particular, due to directivity effects (which are better accommodated in the EGF approach). Second, the EGF approach is performed in the Fourier domain, whereas the GMPE fitting is done in the response spectral domain. We conclude that EGF stress-drop models provide useful constraints for GMPE development, when used in combination with calibration to a ground-motion database.
Percepciones de los estudiantes frente a la satisfacción personal desde el enfoque del desarrollo humano
Authors: Alvarez Gallego Monica Maria , Montoya López Ana Maria 
Published: March 2020

El presente artículo tiene como objetivo comprender las percepciones de los estudiantes frente a la satisfacción personal y su relación con los procesos educativos desde un enfoque de desarrollo humano. Metodológicamente se fundamenta en el paradigma histórico hermenéutico desde una perspectiva cualitativa, a través del estudio de caso. Para la recolección de la información se trabaja con técnicas como el grupo focal, la entrevista semiestructurada y la observación no participante. Los resultados dan cuenta de cómo el desarrollo humano y la satisfacción que sienten y viven los docentes se convierte en una estrategia, no solo de mejoramiento personal, sino también a decir de los estudiantes se refleja en la calidad de los procesos educativos. Como conclusión resalta la vinculación que realizan los estudiantes entre la gestión académica, el desarrollo humano de los docentes, su evolución personal y académica con los procesos de mejoramiento continuo al interior del aula y la calidad educativa.
DETERMINATION OF THE CONTENT OF HYOSCYAMUS RETICULATUS SEEDS BY XRF METHOD AND ANTIBACTERIAL CHARACTERISTICS OF ETHYL ALCOHOL EXTRACT
Authors: AKBAŞ Perihan , KAYA Elife , ALKAN Hicran , CEYLAN Gökhan 
Published: March 2020

Hyoscyamus reticulatus is a member of the Solanaceae family and is
represented by six species in Turkey. Hyoscyamus species contain important
tropane alkaloids, which have antispasmodic, anticholinergic, analgesic and
sedative effects. In this study, we aimed to determinate content of Hyoscyamus reticulatus plant seed by XRF
(X-ray Fluorescence Spectrometry) and investigate the antibacterial activity of
the ethanol extract of H. reticulatus seed.
Energy dispersive X-ray fluorescence (XRF) spectrometry is one of the important
instruments which used to determine the elemental and chemical composition of
all types of liquids and solids, allows quick and accurate qualitative and
quantitative analysis of elements. In this study, content of H. reticulatus plant seeds were
determined by XRF method; While the seeds have content rates % 1.98 K2O
(%1.65 K), %1.22 P2O5 (%0.53 P), % 0.80 SO3 (%
0.32 S), % 0.49 CaO (%0.35 Ca), %0.26 Fe2O3 ( %0.18
Fe), %0.13 Cl, %0.11 MgO (%0.07 Mg), %0.10 ZnO ( %0.08 Zn), %0.06 MoO3 (
%0.04 Mo),%0.05 SiO2 (%0.02 Si), %0.02 Cu, %0.02 MnO (%0.01
Mn), NiO (67 ppm) and Al2O3 (94 ppm) rates were
determined at the ppm level. H.
reticulatus seeds were extracted with for antibacterial activity test and Escherichia coli, Pseudomonas aeruginosa,
Pasteurella multocida, Yersinia enterocolitica, Klebsiella pneumoniae,
Staphylococcus aureus and Salmonella
enteridis bacteria were used. The extract did affect no bacteria except Pasteurella multocida (10 mm).
Assessment of vibratory QST abnormality in diabetic patients with special correlation to duration of diabetes
Authors: Saha Kaushik , Saha Dipa 
Published: March 2020

Background: Peripheral Neuropathy is one of the common microvascular complications in diabetes mellitus affecting both large and small nerve fibres. In present study we have assessed the impairment of vibration perception threshold (VPT) QST that enables evaluation of affection of large myelinated (Aα and Aβ) fibres. Methods: Authors used Biothesiometer in our study that served a satisfactory tool for quantitating vibratory sense. In our study 120 diabetic patients between 30 to 60 yrs age group with duration of illness ≤10 yrs, 10-20 years and more than 20 years were subjected to Vibratory QST by instrument (Vibrotherm Dx) at several specific points of feet.Results: The result observed is, 73.2% (n=22) diabetics with clinical neuropathy show impairment of vibration sense, while 60% of diabetic patients without clinical neuropathy also show impairment of vibration sense. Result suggests involvement of nerve fibres in a subclinical stage in diabetic patients. Relation between vibratory QST and duration of diabetes is also established, Chi-square trend test is done and it shows there is positive trend with duration of diabetes and it is statistically significant p≤0.001.Conclusions: This study suggests that Vibratory QST should be carried out in every diabetic patient irrespective of clinical neuropathy and duration of diabetes, for early detection, progression & institution of therapy.
Fatigue, Nonrestorative Sleep and Associated Factors Among Sudanese Patients with Type 2 Diabetes: A Case-Control Study
Authors: Mirghani Hyder Osman 
Published: March 2020

Background: Fatigue, nonrestorative sleep, and other sleep disorders could be pointers to serious medical problems like obstructive sleep apnea; when present in patients with diabetes, they exacerbate each other deleterious consequences. The present study aimed to assess fatigue, nonrestorative sleep, sleep duration, and daytime sleepiness among patients with type 2 diabetes.
Methods: This cross-sectional descriptive study was conducted among 103 consecutive patients with type 2 diabetes and 121 healthy controls attending an outpatient clinic in Omdurman, Sudan during the period from December 2015 to June 2016. All participants signed a written informed consent and were interviewed using a questionnaire based on Epworth Sleepiness Scale to assess subjective nonrestorative sleep, sleep duration, and snoring. A blood sample was taken for the HbA1c. The local ethical committee approved the research, and chi-square test and t-test were used for data analysis.
Results: Highly significant statistical differences were observed between the diabetic patients and the control subjects regarding fatigue, nonrestorative sleep, sleep duration, snoring, and excessive daytime sleepiness (P-value < 0.001). Patients with fatigue had higher nonrestorative sleep than those without, no significant differences were found between patients with the symptoms of fatigue and those without regarding excessive daytime sleepiness, snoring, sleep duration, and the HbA1c (P-value > 0.05).
Conclusions: Fatigue, nonrestorative sleep, sleep duration, excessive daytime sleepiness, and snoring were common among patients with type 2 diabetes than their healthy counterparts, diabetic patients with fatigue had more nonrestorative sleep than those without. The reliance on a self-administered questionnaire is a limitation of the study.
Keywords: fatigue, nonrestorative sleep, excessive daytime sleepiness, diabetes mellitus, Sudan
MODEL AKTAN GREIMAS DALAM NOVEL MENCARI PEREMPUAN YANG HILANG KARYA IMAD ZAKI
Authors: Megawati Erna 
Published: March 2020

The aim of this research is to discover the structure of fabula within the novel of Mencari Perempuan Yang Hilang. The method used in the research was narratology. Data is collected using library. Research is analyzed based on the theory of actantial model by Greimas. The result shows if the novel has six actants as suggested by Greimas which are subject, object, sender, receiver, helper, and opponent.
EKSPRESI PENOLAKAN PRAGMATIK ANAK USIA 2—3 TAHUN
Authors: Rosita Farida Yufarlina , Kuniasih Dwi 
Published: March 2020

This study aims to explore the forms of expression of pragmataik rejection in children aged 2—3 years. In addition, this study also aims to explain the factors that influence the acquisition of the language of the child so as to act pragmatic speech. The method used in this research is qualitative descriptive. Qualitative descriptive method is a method that attempts to describe and interpret objects as they are. Data collection methods are carried out with several techniques, namely, see, record, and note. The results of this study indicate the existence of two forms of expression of rejection that is explicit and implicit. The form of exclusion is classified into nonverbal and declarative rejection. There are several forms of implicit refusal: implicit refusal by reason of, interrogative implicit refusal, alternative implicit rejection, implicit declarative rejection, implicit rejection with demand. In addition, the results of this study indicate a factor that affects the pragmatic ability of children 2—3 years, namely natural factors, cognitive development, socioeconomic, and family.
Statistical Optimization of Parameters for the Enhancement of Lipase Activity
Authors: Das Prama , Chattopadhyay Soham 
Published: March 2020

Abstract
In this present study, lipase producing bacteria were isolated and screened from an indigenous soil sample and was used for lipase production with high enzyme activity. Different production media were screened and lipase production was found to be induced by olive oil, 14 mL/L, in the production medium. It was observed from Luedeking and Piret model that the lipase production was mixed growth associated with its maximum activity at 37 °C and pH 7. To understand the interaction of different parameters, statistical optimization using Response Surface Methodology was performed and the standardized conditions obtained were as follows: Peptone 10 g/L, yeast extract 7.5 g/L and olive oil 14 mL/L. The predicted data were validated and the model predicted was significant with maximum specific activity of 1.1 µmole/min/mg proteins. The lipase specific activity was found to be enhanced by 10% and 23% after a single parameter and statistical optimization respectively.
Early prodromal sensory neuropathy in Pink1-SNCA double mutant Parkinson mice
Authors: Valek Lucie , Tran Bao , Wilken-Schmitz Annett , Trautmann Sandra , Heidler Juliana , Schmid Tobias , Brüne Bernhard , Thomas Dominique , Deller Thomas , Geisslinger Gerd , Auburger Georg , Tegeder Irmgard 
Published: March 2020

Abstract
BACKGROUND: Parkinson's Disease (PD) is frequently associated with a prodromal sensory neuropathy, which manifests as sensory loss and eventually chronic pain. METHODS: The present study assessed somatosensory functions and the pathology of somatosensory neurons in Pink1-/-SNCAA53T double mutant mice (Pink1SNCA) who develop a PD-like disease > 15 months of age. RESULTS: Pink1SNCA mice showed the first manifestations of sensory dysfunctions at 6 months of age, which were characterized by a loss of thermal sensitivity but sparing of mechanical sensation, and decline of olfactory perception of pleasant odors. Mechanistically, the loss of thermal sensitivity was attributed to a strong reduction of transient receptor potential TRPV and TRPA channels at mRNA, protein and functional levels in the dorsal root ganglia (DRGs). Primary sensory neurons responded much less to stimulations with capsaicin, formalin or depolarization as assessed by calcium imaging. RNA sequencing pointed to additional deregulations of voltage dependent potassium channel subtypes, lowering of acidic fibroblast growth factor driven support, and alterations of sphingolipid metabolism. Analyses of sphingolipids of multiple classes revealed an accumulation of glucosylceramides mainly in the DRGs and loss of sphingosines and sphinganines in the sciatic nerve. Transmission electron microscopy of the DRGs revealed a higher frequency of neurons with swollen mitochondria, which was associated with a decrease of mitochondrial respiration in sensory ganglia, but not in the brain. CONCLUSION: The data support the view of a prodromal sensory disease in PD resulting from a combination of lipid allostasis and mitochondrial damage. Hence, Pink1SNCA mice phenocopy the PD-associated prodromal sensory neuropathy and reveal novel mechanistic insight.
Global analysis insights into coupling relationship between lignan and lignin metabolism of flax
Authors: Xie Dongwei , Dai Zhigang , Yang Zemao , Tang Qing , Sun Jian , Su Jianguang 
Published: March 2020

Abstract
Background: Flax ( Linum usitatissimum L.) is one of the most important economic crops in the world. The lignin content of flax stems directly determines the quality of flax fibers. Flax seeds contain lignans of highly beneficial for human health.Results: To elucidate the metabolic relationship between these compounds and the regulatory nodes of their metabolic processes, third generation (PacBio Iso-Seq) and second generation (Illumina) sequencing technologies were used to sequence the transcriptomes of a pair of flax cultivars with significant differences in lignan content. It was discovered that the differential expressed genes (DEGs) are significantly enriched in the lignin and lignan biosynthesis pathways. Furthermore, there are seven genes with significant differences in expression that were annotated as UDP-glucosyl transferases ( UGTs ). We found that lignan and lignin content is significantly negatively correlated with each other. SEM observations on flax bast fibers provided further evidence of this relationship.Conclusions: This is the first full-length transcriptome analysis on flax plants using third-generation sequencing technologies, and it is also the first study to observe a negative correlation between lignin and lignan content of flax plants. Furthermore, it was found that UGTs are likely to be regulatory node genes for lignan and lignin metabolism.
The miRNA COMPLEXES AGAINST CORONAVIRUSES COVID-19, SARS-CoV, and MERS-CoV
Authors: Ivashchenko Anatoliy , Rakhmetullina Aizhan , Akimniyazova Aigul , Aisina Dana , Pyrkova Anna 
Published: March 2020

Abstract
The possibility of using miRNA (mRNA-inhibiting RNA) to inhibit infections caused by the coronaviruses COVID-19, SARS-CoV, and MERS-CoV has been shown. Using bioinformatics approaches, completely complementary miRNA (cc-miRNA) complexes were predicted to be able to bind and inhibit the translation of coronavirus proteins and the replication of COVID-19, SARS-CoV, and MERS-CoV genomes. For complexes of seven cc-miRc for COVID-19, seven cc-miRs for SARS-CoV, and eight cc-miRm for MERS-CoV, the interactions with the RNA genomes (gRNAs) of the corresponding coronaviruses was evaluated. The free energy of the interactions of cc-miRNAs with binding sites was significantly higher than the free energy of the interactions with other regions in gRNA, which ensures high selectivity of the binding of cc-miRNAs. Weak binding of cc-miRNAs to the mRNAs of 17508 human genes was shown, which suggests the absence of side effects of the cc-miRNAs in humans. A feature of this method is the simultaneous inhibition of translation and replication by several cc-miRNAs binding from the 5' end to the 3' end of gRNA. The use of several cc-miRNAs to suppress infections allows each of them to be used at a lower concentration to avoid side effects when one cc-miRNA is introduced into humans at a high concentration.
Prognostic Implications of Preoperative Pneumonia to Patients Undergoing Hip Fracture Surgery or Arthroplasty
Authors: Shen Jiawei , Zhang Peixun , An Youzhong , Jiang Baoguo 
Published: March 2020

Abstract
BACKGROUND: Preoperative pneumonia is one of the underlying comorbidities of patients undergoing hip fracture surgery or arthroplasty, which had been reported with an increased 30-day mortality. However, the influences that preoperative pneumonia or its different severity had to long term survival were hardly been reported. METHODS: In this retrospective observational study, we reported outcomes of patients undergoing hip fracture surgery or arthroplasty with or without a diagnosis of preoperative pneumonia. We analyzed risk factors of 1-year mortality for patients with preoperative pneumonia and calculated the adjusted risk of 1-year mortality that stratified for pneumonia severity evaluated with CURB-65 score. Survival rates of patients free of pneumonia or with different pneumonia severity were also reported with COX regression. RESULTS: The incidence of preoperative pneumonia was 7.86% in our cohort. Compared to patients without preoperative pneumonia, patients with this condition had longer hospital stay (15 vs. 12, p<0.001）and ICU length of stay (7 vs. 0, p<0.001), higher 30-day mortality (11.9% vs. 5%, p=0.002) and 1-year mortality(33.9% vs. 16.3%, p<0.001). BMI<18.5 kg/m 2 , CURB-65 score ≥3 were risk factors of 1-year mortality in patients with preoperative pneumonia, while regional anesthesia was a protective factor for 1-year mortality. There was a linear trend of CURB-65 score to 1-year mortality after adjustment for BMI and anesthesia type (p for trend = 0.006). when CURB-65 score ≥3, patients had significant risk of 1-year mortality (OR: 3.85-7.87). COX regression reveals a higher risk of mortality over time in patient with preoperative pneumonia, as severity increases (CURB-65 score ≥3), the difference of risk to patients without preoperative pneumonia became significant. CONCLUSION: In this single center retrospective study that consists of patients undergoing hip fracture surgery or arthroplasty, patients with preoperative pneumonia had worse prognoses than patients without this condition. BMI<18.5 kg/m 2 , CURB-65 score ≥3 were risk factors of 1-year mortality in patients with preoperative pneumonia, while regional anesthesia was a protective factor for 1-year mortality. In patients with preoperative pneumonia, CURB-65 score ≥3 indicated higher risk of mortality over time.
Associated factors with reaching a scientific publication during medical training: evidence from 40 medical schools surveyed in Latin America.
Authors: Valladares-Garrido Mario J. , Mejia Christian R. , Rojas-Alvarado Annel B. , Araujo-Chumacero Mary M. , Córdova-Agurto Jhacksson S. , Fiestas Jessica , Rojas-Vilar Feeder J. , Culquichicon Carlos 
Published: March 2020

Abstract
Background

Scientific publication during medical training is key to promote an enduring cutting-edge knowledge. The promotion of science among medical students in Latin America is a multi-sphere issue hampered by the unawareness of governments to invest in national research, as well as a lack of support from local universities. This study aims to determine the factors associated to reach a scientific publication during medical training among Latin American medical students of local scientific societies.

Methods

This is a secondary-data-analysis of a study conducted in 2016 to evaluate the use of information and communications technologies (TICs) among medical students of 40 local scientific societies of medical students affiliated to the Latin American Federation of Medical Students Scientific Societies (FELSOCEM, in Spanish). Local teams in each local scientific society surveyed self-reported scientific publications and explored its association with socioeconomic, academic, and research training conditions. We included medical students enrolled in the 2016-I term and excluded medical interns. We implemented nested models to identify covariates associated with self-reported scientific publication until reaching a parsimonious mixed-effect multilevel model clustered by medical scientific society.

Results

We surveyed 11,587 medical students. The prevalence of scientific publications increased in 36% among medical students affiliated to a Scientific Society of Medical Students [parsimonious prevalence ratio (PRp)=1.36, 95%CI=1.16–1.59], 51% among medical students with advanced English proficiency [PRp=1.51, 95%CI=1.21 – 1.87], 85% among medical students who attended a scientific writing skills course [PRp=1.85, 95%CI=1.59–2.15], 81% among medical students who use Sci-hub [PRp=1.81, 95%CI=1.50–2.20], and 108% among medical students who have access to a pirated academic account [PRp=2.08, 95%CI=1.83–2.36].

Conclusions

Reaching a scientific publication among medical students is associated with being affiliated to a Scientific Society of Medical Students, English proficiency, training in scientific writing, use of Sci-Hub, and pirated academic accounts.
<b>CURADORIA DIGITAL PARA DEMOCRATIZAÇÃO DO ACESSO À EDUCAÇÃO SUPERIOR</b>: o caso do Projeto Ciber-Cidadania
Authors: Costa Heloisa , Eli Maria Carolina , Vianna William Barbosa 
Published: March 2020

Gerenciar as informações em meio digital visando seu uso e reuso é um desafio que os profissionais que lidam com o ambiente digital precisam enfrentar. A Curadoria Digital, por meio das etapas de seleção, preservação, manutenção e arquivamento dos objetos digitais, vem auxiliar nessa tarefa. O objetivo deste estudo é aplicar a curadoria digital na gestão da informação, no contexto de uma plataforma educacional digital, para atender a uma escola pública da cidade de Florianópolis. A pesquisa é decorrente de um projeto de extensão em que foram disponibilizadas na plataforma informações sobre o ENEM e sobre as obras literárias do Vestibular da UFSC. Os procedimentos metodológicos adotados para este estudo partiram do método indutivo, da pesquisa bibliográfica, exploratória e descritiva, aplicada à escola estudada, por meio da pesquisa-ação, com o objetivo de resolver o problema relacionado à disponibilização da informação na plataforma digital. Como resultado destaca-se que é possível utilizar uma plataforma digital com investimento mínimo e seu uso auxilia no processo de ensino-aprendizagem, tendo em vista que serve como uma ferramenta complementar às aulas presenciais. As etapas de Gestão da Informação junto às de curadoria digital possibilitaram ter uma visão mais clara a respeito de quais cuidados deve-se ter com a informação digital, compreendendo que o ciclo de curadoria pode ser adaptado para aplicações específicas. O resultado da primeira etapa do projeto se mostrou positivo, pois teve a adesão dos usuários da comunidade, com a qual já foram delineados os passos seguintes do projeto.Palavras-chave: Curadoria digital. Gestão da Informação. Plataforma digital. Recurso educacional.