bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tail dependence in emerging ASEAN-6 equity markets: empirical evidence from quantitative approaches
Authors: Duong Duy , Huynh Toan Luu Duc 
Published: January 2020

AbstractThis study contributes a rich set of quantitative methodologies including a non-parametric approach (Chi-plots and K-plots) as well as copulas (traditional and time-varying with Student’s t-copulas) to the existing literature in terms of determining the dependence structure in ASEAN stock markets. Drawing on the emerging ASEAN equity returns of six countries from January 2001 to December 2017, we found that Student’s t-copulas under time-varying approach is the most appropriate approach to explain these co-movements. Among all research return pairs, the dependence between Vietnam and other ASEAN equity indices has the lowest value. Meanwhile, all couples show left- and right- tail dependence by each pair for pre- and post- financial shocks. Hence, diversification across these pairs of equity markets from ASEAN is still adequate for international investors, though it might trigger contagion risks.
MicroRNAs in bovine milk exosomes are bioavailable in humans but do not elicit a robust pro-inflammatory cytokine response
Authors: Mutai Ezra , Ramer-Tait Amanda E. , Zempleni Janos 
Published: January 2020

Abstract
Background
Bovine milk exosomes are studied for their roles as bioactive food compounds and as vehicles for drug delivery. Both lines of investigation converge on immune function, e.g., immune regulation by absorption of microRNAs encapsulated in milk exosomes across species boundaries, and the possibility of exosomes and their cargos triggering an immune response if used in drug delivery. This study assessed the bioavailability of immune-related microRNAs from bovine milk and changes in plasma cytokine concentrations after milk consumption in humans, and the secretion of cytokines by human peripheral blood mononuclear cells (PBMCs) cultured with milk exosomes transfected with immune-relevant microRNAs.

Results
Human plasma samples were collected before and at timed intervals after a milk meal and analyzed for concentrations of six immune-relevant microRNAs and nine cytokines. The peak plasma concentrations of miR-15b-5p, miR-21-5p, miR-106b-5p, and miR-223-3p were 60 ± 9.80% to 162 ± 31.80% higher after milk consumption (Ct values 23 ± 1.2 to 26 ± 1.1 cycles) compared to baseline values (P < 0.05). Plasma concentrations of TNF-alpha were not significantly different before versus after milk consumption; eight other cytokines were below detection limit. PBMCs were collected before and six hours after milk consumption and cultured with or without concanavalin A (ConA). TNF-alpha, IL-1β, IL-6 and IL-10 were detectable in culture media, but concentrations did not depend on milk consumption prior to PBMC isolation (P > 0.05). When PBMC cultures from fasted subjects were supplemented with milk exosomes that had been transfected with immune-relevant microRNAs, the concentrations of IL-1β, IL-6, IL-10 and TNF-alpha were 29 ± 12% to 220 ± 33% higher than controls cultured with non-transfected exosomes (P < 0.05), but cytokine concentrations were not different compared with control exosomes transfected with scrambled microRNA (P > 0.05).

Conclusions
MicroRNAs in bovine milk exosomes are bioavailable. Milk exosomes do not elicit an increase of plasma cytokines following oral administration.

Trial registration
ISRCTN registry ID: 16329971. Retrospectively registered on February 7th, 2019.
An emerging framework for fully incorporating public involvement (PI) into patient-reported outcome measures (PROMs)
Authors: Carlton J. , Peasgood T. , Khan S. , Barber R. , Bostock J. , Keetharuth A. D. 
Published: January 2020

AbstractPatient-reported outcome measures (PROMs) are widely used in the United Kingdom (UK) and internationally to report and monitor patients’ subjective assessments of their symptoms and functional status and also their quality of life. Whilst the importance of involving the public in PROM development to increase the quality of the developed PROM has been highlighted this practice is not widespread. There is a lack of guidance on how public involvement (PI) could be embedded in the development of PROMs, where the roles can be more complex than in other types of research. This paper provides a timely review and sets out an emerging framework for fully incorporating PI into PROM development.
Patients’ perspectives of outcomes after total knee and total hip arthroplasty: a nominal group study
Authors: Goodman Susan M. , Mehta Bella , Mirza Serene Z. , Figgie Mark P. , Alexiades Michael , Rodriguez Jose , Sculco Peter , Parks Michael , Singh Jasvinder A. 
Published: January 2020

Abstract
Background
While total joint replacements (TJR) are frequently performed, there is little qualitative research to define the outcomes most important to patients.

Methods
Patients who had received total hip (THR) or total knee replacements (TKR) participated in 8 nominal groups to answer the question “What result/results matter the most to a patient undergoing/having a knee or hip replacement?” Total 270 votes were allocated.

Results
Eight nominal groups were performed with 45 patients, 6 groups with mean age (71.1 ± 9.3), and 2 with 9 younger patients (mean age 36.8 ± 7.4). All had TJR between 2016 and 2018; overall, 40% were male, 15.6% were Black, and 75% were performed for osteoarthritis. While all groups ranked the same top 3 outcomes, responses varied with age: 1) relief of pain (46% vs. 35% in the young groups); 2) improved function including mobility (29% vs. 18% in the young groups); 3) restored quality of life (13% vs 33% of votes in the younger group).

Conclusion
Relief of pain and restoration of function, and improved quality of life are the 3 outcomes ranked highest by patients, confirming their inclusion in TJR clinical trials.
The sedimentary dynamics of Sabellaria alveolata bioconstructions (Ostia, Tyrrhenian Sea, central Italy)
Authors: Lisco Stefania Nunzia , Acquafredda Pasquale , Gallicchio Salvatore , Sabato Luisa , Bonifazi Andrea , Cardone Frine , Corriero Giuseppe , Gravina Maria Flavia , Pierri Cataldo , Moretti Massimo 
Published: January 2020

AbstractSabellaria alveolata (Linnaeus 1767) is a polychaete able to build bioconstructions of different thickness, size and patchiness, in intertidal and subtidal environments. Its biological features have been the object of numerous studies worldwide. The worm reefs are formed by millions of tubes built by sand and shells (whole or in fragments) bonded together with a strong glue produced by the worm itself. Hence, Sabellaria alveolata represents a sedimentological asset for the coastal protection, since it contributes to create natural barriers against storm waves and erosion, and supplies the beach with new sandy deposits. This work shows a multidisciplinary approach to studying a bioconstruction of Sabellaria alveolata along the Latium coast (Ostia, Tyrrhenian Sea, central Italy), proposing image analysis as a novel technique to investigate worm reefs, along with classical sedimentological/ecological tools. The Sabellaria bioconstructions have been analysed at different scales of observation, suggesting the more appropriate strategies to develop a reliable model illustrating the different growth steps of these bioconstructions.
Corrected calculation of the overestimated ejection fraction in valvular heart disease by phase-contrast cardiac magnetic resonance imaging for better prediction of patient morbidity
Authors: Yousef Hosam A. , Hamdan Abdulrahman E. S. , Elminshawy Ahmed , Mohammed Nisreen A. A. , Ibrahim Ahmed S. 
Published: January 2020

Abstract
Background
To establish a more accurate technique for the assessment of the left ventricular function correlated with patients’ clinical condition avoiding the miscalculation of the ejection fraction in valvular regurgitation. A prospective study carried out between July 2018 and June 2019. The studied group included 35 subjects, 25 patients with valvular regurgitation, and 10 healthy control subjects. All subjects underwent cardiovascular magnetic resonance examination to evaluate the ejection fraction by two methods: the volumetric method which assesses stroke volume via subtraction of the end-systolic volume from the end-diastolic volume, and phase-contrast method which assesses the aortic stroke volume via a through-plane phase contrast across the aortic valve. The sensitivity, specificity, P value and the area under the curve of both methods were calculated.

Results
In the healthy group, using the volumetric method, the calculated mean ejection fraction was 62.44 ± 6.61, while that calculated by the phase-contrast method was 64.34 ± 5.33, with a non-significant difference (P = 0.62) showing the validity of the phase-contrast method. In the patients’ group, by using the volumetric method, the calculated mean ejection fraction was 47.17 ± 14.31%, which was significantly higher than that calculated by the phase-contrast method (29.39 ± 7.98%) (P = 0.02). According to the results of the calculation of the ejection fraction by the volumetric method, there were 18 patients (72%) having impaired cardiac function and 7 (28%) patients of normal function; while according to the phase-contrast method, all the 25 patients had impaired cardiac function. The current study shows that the phase-contrast cardiac magnetic resonance had 89.29% sensitivity and 85.7% specificity in diagnosing impaired cardiac function with the area under the curve of 0.87 (P = 0.00).

Conclusion
The phase-contrast cardiac magnetic resonance can provide a better assessment of the ejection fraction in valvular regurgitation.
Linking Porter’s generic strategies to firm performance
Authors: Islami Xhavit , Mustafa Naim , Topuzovska Latkovikj Marija 
Published: January 2020

AbstractIn this study, the significance of using Porter’s generic strategies in firms that operate in competitive environments is investigated. The aim is to indicate the effects of Porter’s generic strategies (low-cost strategy, differentiation strategy, and focus strategy) on firm performance. The questionnaires of the study have been prepared, the responses have been obtained, and the econometric model is constructed to measure these relationships. Findings stemmed by data that were taken from 113 firms that operate in the Republic of Kosovo.ttest, Pearson’s correlation analysis, and multivariate regression analysis were used to provide testing of hypotheses. Econometric results suggest that pursuing differentiation strategy provides higher firm performance compared to two other Porter’s generic strategies (low-cost strategy or focus strategy) that have a positive impact as well.
Effects of parenting interventions for mothers with depressive symptoms and an infant: systematic review and meta-analysis
Authors: Rayce Signe B. , Rasmussen Ida S. , Væver Mette Skovgaard , Pontoppidan Maiken 
Published: January 2020

Background
Postpartum depression is common in the perinatal period and poses a risk for the development of the infant and the mother–infant relationship. Infancy is a critical developmental period of life and supportive parenting is crucial for healthy development, however, the effects of interventions aimed at improving parenting among mothers with depression are uncertain.

Aims
To assess the effects of parenting interventions on parent–child relationship and child development among mothers with depressive symptoms with 0–12-month-old infants.

Method
We conducted a systematic review with the inclusion criteria: (a) randomised controlled trials of structured psychosocial parenting interventions for women with depressive symptoms and a child aged 0–12 months in Western Organisation for Economic Co-operation and Development countries, (b) minimum three sessions with at least half of these delivered postnatally and (c) outcomes relating to the parent–child-relationship and/or child development. Publications were extracted from 10 databases in September 2018 and supplemented with grey search and hand search. We assessed risk of bias, calculated effect sizes and conducted meta-analysis.

Results
Eight papers representing seven trials were included. We conducted meta-analysis on the post-intervention parent–child relationship. The analysis included six studies and showed no significant effect. For individual study outcomes, no significant effects on the majority of both the parent–child relationship and child development outcomes were reported.

Conclusions
No evidence of the effect of parenting interventions for mothers with depressive symptoms was found on the parent–child relationship and child development. Larger studies with follow-up assessments are needed, and future reviews should examine the effects in non-Western countries.
Estrogen and Progesterone Receptor Testing in Breast Cancer: ASCO/CAP Guideline Update
Authors: Allison Kimberly H. , Hammond M. Elizabeth H. , Dowsett Mitchell , McKernin Shannon E. , Carey Lisa A. , Fitzgibbons Patrick L. , Hayes Daniel F. , Lakhani Sunil R. , Chavez-MacGregor Mariana , Perlmutter Jane , Perou Charles M. , Regan Meredith M. , Rimm David L. , Symmans W. Fraser , Torlakovic Emina E. , Varella Leticia , Viale Giuseppe , Weisberg Tracey F. , McShane Lisa M. , Wolff Antonio C. 
Published: January 2020

PURPOSETo update key recommendations of the American Society of Clinical Oncology/College of American Pathologists estrogen (ER) and progesterone receptor (PgR) testing in breast cancer guideline.METHODSA multidisciplinary international Expert Panel was convened to update the clinical practice guideline recommendations informed by a systematic review of the medical literature.RECOMMENDATIONSThe Expert Panel continues to recommend ER testing of invasive breast cancers by validated immunohistochemistry as the standard for predicting which patients may benefit from endocrine therapy, and no other assays are recommended for this purpose. Breast cancer samples with 1% to 100% of tumor nuclei positive should be interpreted as ER positive. However, the Expert Panel acknowledges that there are limited data on endocrine therapy benefit for cancers with 1% to 10% of cells staining ER positive. Samples with these results should be reported using a new reporting category, ER Low Positive, with a recommended comment. A sample is considered ER negative if < 1% or 0% of tumor cell nuclei are immunoreactive. Additional strategies recommended to promote optimal performance, interpretation, and reporting of cases with an initial low to no ER staining result include establishing a laboratory-specific standard operating procedure describing additional steps used by the laboratory to confirm/adjudicate results. The status of controls should be reported for cases with 0% to 10% staining. Similar principles apply to PgR testing, which is used primarily for prognostic purposes in the setting of an ER-positive cancer. Testing of ductal carcinoma in situ (DCIS) for ER is recommended to determine potential benefit of endocrine therapies to reduce risk of future breast cancer, while testing DCIS for PgR is considered optional. Additional information can be found at www.asco.org/breast-cancer-guidelines .
Understanding Aboriginal Peoples’ Cultural and Family Connections Can Help Inform the Development of Culturally Appropriate Cancer Survivorship Models of Care
Authors: Ristevski Eli , Thompson Sharyn , Kingaby Sharon , Nightingale Claire , Iddawela Mahesh 
Published: January 2020

PURPOSE To explore the cancer diagnosis, treatment, and survivorship experiences of Aboriginal people in the Gippsland region, Victoria, Australia, and identify factors critical to the development of a culturally appropriate cancer survivorship model of care. PATIENTS AND METHODS Yarning circles were used to capture the stories of 15 people diagnosed with cancer and/or those of family members. Yarning circles were conducted in two locations in the Gippsland region. Sessions were facilitated by an Aboriginal Elder, audio recorded, and transcribed verbatim. Thematic analysis of the data were triangulated among three researchers and incorporated researcher reflexivity. RESULTS Cultural connections and family were critical supports on the cancer journey. Putting the needs of the family first and caring for sick family members were more important than an individual’s own health. There was “no time to grieve” for one’s own cancer diagnosis and look after oneself. Cancer was a private experience; however, the constancy of deaths highlighted the importance of raising family awareness. Health professionals did not always understand the importance of people’s cultural and family supports in their treatment and recovery. There were negatives attitudes in hospitals when family come to visit, seeing family as too large and overstaying visiting times. Health professionals did not seek family assistance with communication of information to family members whose literacy level was low, nor did they include family in treatment decision-making. Access to services depended on family support with transport, finances, and family responsibilities, often resulting in lapses in treatment and follow-up services. CONCLUSION Understanding the importance of Aboriginal peoples’ cultural and family connections can help to inform the development of culturally safe cancer survivorship models of care.
Schizosaccharomyces pombe DNA translocases Rrp1 and Rrp2 have distinct roles at centromeres and telomeres that ensure genome stability
Authors: Barg-Wojas Anna , Muraszko Jakub , Kramarz Karol , Schirmeisen Kamila , Baranowska Gabriela , Carr Antony M. , Dziadkowiec Dorota 
Published: January 2020

ABSTRACT
The regulation of telomere and centromere structure and function is essential for maintaining genome integrity. Schizosaccharomyces pombe Rrp1 and Rrp2 are orthologues of Saccharomyces cerevisiae Uls1, a SWI2/SNF2 DNA translocase and SUMO-targeted ubiquitin ligase. Here, we show that Rrp1 or Rrp2 overproduction leads to chromosome instability and growth defects, a reduction in global histone levels and mislocalisation of centromere-specific histone Cnp1. These phenotypes depend on putative DNA translocase activities of Rrp1 and Rrp2, suggesting that Rrp1 and Rrp2 may be involved in modulating nucleosome dynamics. Furthermore, we confirm that Rrp2, but not Rrp1, acts at telomeres, reflecting a previously described interaction between Rrp2 and Top2. In conclusion, we identify roles for Rrp1 and Rrp2 in maintaining centromere function by modulating histone dynamics, contributing to the preservation of genome stability during vegetative cell growth.
A GTPase-induced switch in phospholipid affinity of collybistin contributes to synaptic gephyrin clustering
Authors: Kilisch Markus , Mayer Simone , Mitkovski Miso , Roehse Heiko , Hentrich Jennifer , Schwappach Blanche , Papadopoulos Theofilos 
Published: January 2020

ABSTRACT
Synaptic transmission between neurons relies on the exact spatial organization of postsynaptic transmitter receptors, which are recruited and positioned by dedicated scaffolding and regulatory proteins. At GABAergic synapses, the regulatory protein collybistin (Cb, also known as ARHGEF9) interacts with small GTPases, cell adhesion proteins and phosphoinositides to recruit the scaffolding protein gephyrin and GABAA receptors to nascent synapses. We dissected the interaction of Cb with the small Rho-like GTPase TC10 (also known as RhoQ) and phospholipids. Our data define a protein–lipid interaction network that controls the clustering of gephyrin at synapses. Within this network, TC10 and monophosphorylated phosphoinositides, particulary phosphatidylinositol 3-phosphate (PI3P), provide a coincidence detection platform that allows the accumulation and activation of Cb in endomembranes. Upon activation, TC10 induces a phospholipid affinity switch in Cb, which allows Cb to specifically interact with phosphoinositide species present at the plasma membrane. We propose that this GTPase-based regulatory switch mechanism represents an important step in the process of tethering of Cb-dependent scaffolds and receptors at nascent postsynapses.
The Problem of Light and Aerial Environment Imaging in an Etude
Authors: Chernova I. , Biktagirov Arslan , Leonova I. 
Published: January 2020

The article reflects the problems arising in the process of teaching painters and designers to create etudes. By the empiric way the authors of the article have come to the conclusion that it is possible to group the problems which students face when reflecting light-and-air environment in etudes. On the basis of vast teaching practice the authors distinguish such most significant problems as:
• difficulty in realizing the limitation of tone range of painting and graphics in comparison with natural surroundings;
• mistakes made in defining the ratio of maximum light and maximum dark elements of the natural surroundings;
• difficulty in reflecting the space depth.
The authors’ vast teaching experience has allowed to formulate a complex approach to eliminating the above mentioned problems combining teaching and technical aspects and providing the following
skills:
• the complex perception of the nature object;
• the ability to establish the ratio of the big main color spots;
• the understanding of the nature objects’ tone and color change mechanism;
• the ability to define the dependence between the visual tone and color and the distance to the object.
To realize the mentioned complex approach the authors suggest implementing a system of different exercises and trainings. In the article they describe two alternative variants of trainings. The first one molds the perception of light-and-air environment by the method of “dyeing”, with the following fixing the molded skills in creating a series of elementary academic settings. The second training is based on the stipulation that watercolor grisaille does not demand any preliminary preparation for perception the influence of light-and-air environment. Thus, according to the training methods, a student automatically gets tone ranging of the whole work area. In the authors’ opinion, in addition to the mentioned exercises, students should be offered less difficult tasks in order to fix the skills and form the dynamic stereotype of defining the light-and-air environment’s influence in etudes.
O wyzwaniach i zadaniach pamięcioznawstwa lingwistycznego
Authors: Chlebda Wojciech 
Published: January 2020

On the Challenges and Tasks of Linguistic Memory Research
The paper summarizes the first stage of development of a new subfield of linguistics known as linguistic memory research, and poses three questions which are important for its further development: what are the mutual relations and tangents between language and memory (both individual and collective), what are the mutual relations between linguistic memory research and the related field of cognitive ethnolinguistics (as well as such disciplines in humanities as historiography and theoretical archaeology), and lastly, in what areas can linguistic memory research and ethnolinguistics support each other most effectively. A greater part of the paper is devoted to a brief overview of the ten problem areas in memory research, and a presentation of specific tasks posed before linguists by questions concentrated in those areas: from the determination of the role of memory in the processes of lexicalization and phraseologization, through the classification of verbal (phonic, lexical, phraseological, syntactic, genre-related, etc.) exponents of memory, and the determination of their role in the learning of aspects of individual and collective memory, up to an analysis of the role of the given ethnic language in the building of large mental constructs interepreting the reality, such as collective memory, linguistic image of the world, and community knowledge.