bluuebunny/crossref_metadata_2025_split huggingface dataset:
Internet banking service quality, e-customer satisfaction and loyalty: the modified e-SERVQUAL model
Authors: Raza Syed Ali , Umer Amna , Qureshi Muhammad Asif , Dahri Abdul Samad 
Published: July 2020

PurposeThis study explores the service quality dimensions in Internet banking and their impact on e-customer’s satisfaction and e-customer’s loyalty. This study tries to inspect the structural association between Internet banking service quality, electronic customer satisfaction and electronic customer loyalty based on separate constructs.Design/methodology/approachIn this present research, quantitative approach is applied. The data is gathered from 500 bank clients in Pakistan by using structured questionnaires, and the theoretical model is tested by partial least square structured equation modeling (PLS-SEM). Moreover, convergent validity and discriminant validity were assessed.FindingsResults show that all the dimensions are found to have a positive and significant influence on customer satisfaction while customer’s satisfaction has a significant and positive impact on customer’s loyalty. Findings indicate that service quality plays a very important role in every society, as it has become the basis for how customers interpret online banking and, in the end, how it interacts and operates with online services.Practical implicationsThis research adds up considerably to the literature of bank marketing, and it is also fruitful for the academicians since it demonstrates the way Internet banking service quality determinants predict e-satisfaction of clients which ultimately raises the e-loyalty of clients. This study is useful for those E-retailers and managers who want to grab e-retailing market.Originality/valueThis research suggests a model which ultimately enhances customer loyalty towards Internet banking service quality through customer satisfaction in Pakistan. It involves modified model of E-SERVQUAL (user friendliness, efficiency of websites, personal need, and site organization) which connects it to electronic customer satisfaction and electronic customer loyalty. Therefore, it will assist the Internet banking sector in building effective marketing tactics, establishing long lasting relationships with clients and acquiring the competitive edge in the market.
Effects of Clinical Reasoning Prompts on Nursing Students’ Clinical Judgment for a Patient Experiencing Respiratory Distress
Authors: Tesoro Mary Gay , Simmons Anne Marie , de Barros Alba Lucia Bottura Leite , Lopes Camila Takao , Guandalini Lidia Santiago , Cruz Elaine Drehmer de Almeida , Maurício Aline Batista 
Published: July 2020

PURPOSETo test the effects of clinical reasoning prompts on students’ clinical judgment of a written case study.METHODSAn experimental pre‐ and posttest study with second semester nursing students (N = 163).FINDINGSThe intervention was insufficient to significantly improve clinical judgment. Students identified that the prompts would help them “narrow… down the problem” and “slow… the decision‐making process” to improve analysis. The most accurate patient problem was identified by 28% of students in pretest and 35% in posttest.CONCLUSIONSThis study provides evidence of variations in nursing students’ clinical judgment and students’ desire to use decision‐making algorithms.NURSING IMPLICATIONSNurse educators should provide students with additional education and practice to identify and solve these types of problems.
Association between transfusion of blood products and acute kidney injury following cardiac surgery
Authors: Rasmussen Sebastian R. , Kandler Kristian , Nielsen Rikke V. , Jakobsen Peter C. , Ranucci Marco , Ravn Hanne B. 
Published: July 2020

BackgroundAcute kidney injury (AKI) is a serious complication following cardiac surgery associated with increased mortality. Red blood cell transfusion enhances the risk of developing AKI. However, the impact of other blood products on AKI is virtually unexplored. The aim of this study was to explore if transfusion of red blood cells, fresh frozen plasma and platelets alone or in combination were associated with postoperative AKI.MethodsPatients undergoing elective on‐pump cardiac surgery were included (n = 1960) between 2012 to 2014. Transfusion data were collected intraoperatively and until the first postoperative day. AKI was classified according to the KDIGO criteria. Data were analysed using univariate and stepwise multiple logistic regression with adjustment for clinical risk factors and complementary blood products.ResultsAKI was observed in 542 patients (27.7%). In univariate analysis and following adjustment for clinical risk factors, administration of red blood cells, freshfrozen plasma and platelets were all independently associated with KDIGO stage 2‐3. Following additional adjustment for complementary blood products, only red blood cell transfusion remained significantly associated with AKI. A dose‐dependent association between volume of red blood cells and degree of AKI severity was observed.ConclusionTransfusion of all blood products in a dose‐dependent manner increased the risk for AKI. However, in multivariate analysis combining all blood products, only red blood cell transfusion remained significantly associated with AKI development.
The inherited methylome landscape is directly altered with paternal aging and associated with offspring neurodevelopmental disorders
Authors: Denomme Michelle M. , Haywood Mary E. , Parks Jason C. , Schoolcraft William B. , Katz‐Jaffe Mandy G. 
Published: July 2020

AbstractPaternal aging and the prevalence of neurodevelopmental disorders in offspring are well documented. Yet, the underlying mechanism and the mode of inheritance have not been conclusively established. Advancing paternal age is a subtle and varying phenotype. As such, it is likely that a threshold for cumulative risk may exist that, if surpassed, culminates in a predisposition to disease and ultimately an observed phenotype in offspring. Epigenetic regulation provides a plausible explanation for the nongenetic paternal transmission of disease susceptibility. With the use of whole‐genome methylation sequencing, the data described herein substantiate an increasingly compromised DNA methylation profile as sperm ages and, for the first time, also demonstrate a generational correlation in sperm and blastocyst of an altered methylome associated with advanced paternal age. Methylation alterations are not randomly distributed across the genome, but appear clustered at certain chromosomal locations, and significantly colocalize with regions of nucleosome retention. Genes associated with autism spectrum disorder, schizophrenia, and bipolar disorder are significantly enriched with causative methylation aberrations in both sperm and embryos from aged fathers. The long‐term health burden and societal economic impact of these conditions are substantial and will continue with increasingly prevalent diagnosis. This work provides a mechanistic link between the paternal age effect and offspring neurodevelopmental disorders leading to a better understanding of causation and investigation into potential future therapy.
Interactions between cannabidiol and Δ9‐tetrahydrocannabinol in modulating seizure susceptibility and survival in a mouse model of Dravet syndrome
Authors: Anderson Lyndsey L. , Low Ivan K. , McGregor Iain S. , Arnold Jonathon C. 
Published: July 2020

Background and PurposeExtracts from the cannabis plant can dramatically improve the health of children suffering from refractory epilepsies such as Dravet syndrome. These extracts typically contain cannabidiol (CBD), a phytocannabinoid with well‐documented anticonvulsant effects, but may also contain Δ9‐tetrahydrocannabinol (Δ9‐THC). It is unclear whether the presence of Δ9‐THC modulates the anticonvulsant efficacy of CBD. Here, we utilized the Scn1a+/− mouse model of Dravet syndrome to examine this question.Experimental ApproachScn1a+/− mice recapitulate core features of Dravet syndrome, including hyperthermia‐induced seizures, early onset spontaneous seizures and sudden death. We assessed the effects on CBD and Δ9‐THC alone, and in combination on hyperthermia‐induced seizures, spontaneous seizures and premature mortality.Key ResultsAdministered alone, CBD (100 mg·kg−1 i.p.) was anticonvulsant against hyperthermia‐induced seizures as were low (0.1 and 0.3 mg·kg−1 i.p.) but not higher doses of Δ9‐THC. A subthreshold dose of CBD (12 mg·kg−1) enhanced the anticonvulsant effects of Δ9‐THC (0.1 mg·kg−1). Sub‐chronic oral administration of Δ9‐THC or CBD alone did not affect spontaneous seizure frequency or mortality while, surprisingly, their co‐administration increased the severity of spontaneous seizures and overall mortality.Conclusion and ImplicationsLow doses of Δ9‐THC are anticonvulsant against hyperthermia‐induced seizures in Scn1a+/− mice, effects that are enhanced by a sub‐anticonvulsant dose of CBD. However, proconvulsant effects and increased premature mortality are observed when CBD and Δ9‐THC are sub‐chronically dosed in combination. The possible explanations and implications of this are discussed.
Inhibition of heparanase protects against pancreatic beta cell death in streptozotocin‐induced diabetic mice via reducing intra‐islet inflammatory cell infiltration
Authors: Song Wen‐Yu , Jiang Xiao‐Han , Ding Ying , Wang Yan , Zhou Ming‐Xuan , Xia Yun , Zhang Chen‐Yu , Yin Chong‐Chong , Qiu Chen , Li Kai , Sun Peng , Han Xiao 
Published: July 2020

Background and PurposeIntra‐islet heparan sulfate (HS) plays an important role in the maintenance of pancreatic islet function. The aim of this study was to investigate the effect mechanism of HS loss on the functioning of islets in diabetic mice.Experimental ApproachThe hypoglycaemic effect of a heparanase inhibitor, OGT2115, was tested in a streptozotocin‐induced diabetic mouse model. The islets in pancreatic sections were also stained to reveal their morphology. An insulinoma cell line (MIN6) and primary isolated murine islets were used to investigate the effect of OGT2115 in vitro.Key ResultsIntra‐islet HS was clearly lost in streptozotocin‐induced diabetic mice due to the increased heparanase expression in damaged islets. OGT2115 prevented intra‐islet HS loss and improved the glucose profile and insulin secretion in streptozotocin‐treated mice. The apoptosis of pancreatic beta cells and the infiltration of mononuclear macrophages, CD4‐ and CD8‐positive T‐cells in islets was reduced by OGT2115 in streptozotocin‐treated mice, but OGT2115 did not alter the direct streptozotocin‐induced damage in vitro. The expression of heparanase was increased in high glucose‐treated isolated islets but not in response to direct streptozotocin stimulation. Further experiments showed that high glucose stimuli could decreased expression of PPARγ in cultured islets, thereby relieving the PPARγ‐induced inhibition of heparanase gene expression.Conclusion and ImplicationsHyperglycaemia could cause intra‐islet HS loss by elevating the expression of heparanase, thereby aggravating inflammatory cell infiltration and islet damage. Inhibition of heparanase might provide benefit for pancreatic beta cell protection in Type 1 diabetes.
DockVis: Visual Analysis of Molecular Docking Trajectories
Authors: Furmanová Katarína , Vávra Ondřej , Kozlíková Barbora , Damborský Jiří , Vonásek Vojtěch , Bednář David , Byška Jan 
Published: July 2020

AbstractComputation of trajectories for ligand binding and unbinding via protein tunnels and channels is important for predicting possible protein–ligand interactions. These highly complex processes can be simulated by several software tools, which provide biochemists with valuable information for drug design or protein engineering applications. This paper focuses on aiding this exploration process by introducing the DockVis visual analysis tool. DockVis operates with the multivariate output data from one of the latest available tools for the prediction of ligand transport, CaverDock. DockVis provides the users with several linked views, combining the 2D abstracted depictions of ligands and their surroundings and properties with the 3D view. In this way, we enable the users to perceive the spatial configurations of ligand passing through the protein tunnel. The users are initially visually directed to the most relevant parts of ligand trajectories, which can be then explored in higher detail by the follow‐up analyses. DockVis was designed in tight collaboration with protein engineers developing the CaverDock tool. However, the concept of DockVis can be extended to any other tool predicting ligand pathways by the molecular docking. DockVis will be made available to the wide user community as part of the Caver Analyst 3.0 software package (www.caver.cz).
Operational Risks and Firm Market Performance: Evidence from China*
Authors: Bai Chunguang , Gao Wenlian , Sarkis Joseph 
Published: July 2020

ABSTRACTThis study investigates how different operational risks impact firm stock market performance. By using a sample of 762 operational risk events published by 543 listed Chinese firms over the period of 2010–2017, we document an overall significantly negative market reaction to operational risks. Specifically, we find that the stock market reaction differs across operational risk types. Man‐made operational risk and disruption operational risk events are associated with greater negative market reaction than nature‐caused and nondisruption operational risk events, respectively. We further find that regulatory violations (external risks) have a smaller negative market reaction than operational incidents (internal risks). Finally, we show that different determinants of competitive forces, namely, a firm's market share and product substitutability, have contrasting effects on the market reaction of all operational risks. These findings can aid various stakeholders to understand the impact of different operational risks and advance cost‐effective mechanisms aimed at mitigating operational risks in China, with potential application to other regions.
Predicting complex spikes in striatal projection neurons of the direct pathway following neuromodulation by acetylcholine and dopamine
Authors: Lindroos Robert , Hellgren Kotaleski Jeanette 
Published: July 2020

AbstractThe input structure of the basal ganglia, striatum, receives dense neuromodulatory input in the form of dopamine and acetylcholine. The two systems are tightly connected, for example, synchronized activity of cholinergic interneurons, leading to increased acetylcholine release, has been shown to directly trigger dopamine release from dopaminergic terminals in striatum. Both signals are further needed for induction of locomotion. High dopamine concentration leads to increased excitability of the direct pathway striatal projection neurons. High cholinergic tone inhibits various potassium channels further increasing the excitability of striatal projection neurons. Here, we investigate the combined effect of concurrent high acetylcholine and dopamine using biophysically detailed models based on rodent data. The aim of the study is to investigate how neuromodulation affects dendritic integration. The result shows that neuromodulation paired with synaptic activation of dendrites can give rise to complex spiking patterns, resembling spike shapes seen in the hippocampus. In the hippocampus, these complex spikes are associated with behavioral time scale plasticity and place cell tuning. We further investigate the mechanisms behind the complex spikes and find that there are two components, one axo‐somatic and one dendritic in origin.
Identification of functional long non‐coding RNAs in gastric cancer by bioinformatics analysis
Authors: Li Yang , Ma Dongyang , Li Tang , Yin Yuan 
Published: July 2020

SummaryLong non‐coding RNAs (lncRNAs) have been proven to play important roles in various cancers, including gastric cancer (GC). However, detailed knowledge about lncRNAs in GC is limited. Therefore we carried out an in‐depth study of public data and found 83 differently expressed lncRNAs in GC. To further confirm the target genes of these lncRNAs, we constructed a co‐expression network between lncRNAs and mRNAs and found three lncRNAs (MBNL1‐AS1, HAND2‐AS1 and MIR100HG) were at the core of the network. By coalition analysis of clinical information and the three lncRNAs’ expression level from The Cancer Genome Atlas (TCGA) and GSE15459 data sets, we found MIR100HG could be a potential prognostic factor. Clinical samples showed patients with higher MIR100HG expression had poorer prognosis, and further experiments demonstrated that MIR100HG was associated with proliferation, migration and invasion of GC cells. Hopefully, MIR100HG might be considered as a novel prognostic factor and biomarker for GC.
Supraventricular bigeminy originating from the mitral annulus: What is the mechanism?
Authors: Yokoyama Masaaki , Yamashita Seigo , Tokuda Michifumi , Mahida Saagar , Yoshimura Michihiro , Yamane Teiichi 
Published: July 2020

AbstractWe present a case of a 67‐year‐old female with a previous history of pulmonary vein isolation for paroxysmal atrial fibrillation who presented with supraventricular bigeminy with a constant coupling interval. The supraventricular bigeminy originated from the anterior mitral annulus with initial mapping suggestive of a focal mechanism. However detailed mapping using an ultrahigh resolution mapping system (with the manual shifting of the annotation window) revealed very low amplitude potentials connecting the previous sinus beat with continuous activation along the mitral annulus. Our observations were indicative of a re‐entry mechanism underlying the supraventricular bigeminy.
Secretion of proteins and antibody fragments from transiently transfected endothelial progenitor cells
Authors: Heller Loree , Thinard Reynald , Chevalier Melanie , Arpag Sezgi , Jing Yu , Greferath Ruth , Heller Richard , Nicolau Claude 
Published: July 2020

AbstractIn neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, multiple sclerosis and amyotrophic lateral sclerosis, neuroinflammation can lead to blood‐brain barrier (BBB) breakdown. After intravenous or intra‐arterial injection into mice, endothelial progenitor cells (EPCs) home to the damaged BBB to promote neurovascular repair. Autologous EPCs transfected to express specific therapeutic proteins offer an innovative therapeutic option. Here, we demonstrate that EPC transfection by electroporation with plasmids encoding the reporter protein GFP or an anti‐β‐amyloid antibody fragment (Fab) leads to secretion of each protein. We also demonstrate the secreted anti‐β‐amyloid Fab protein functions in β‐amyloid aggregate solubilization.
Obstructive monitoring
Authors: Finkle Aaron , Shin Dongsoo 
Published: July 2020

AbstractWe consider a principal–agent relationship in which the principal's monitoring can be obstructive to the agent, reducing the agent's productivity. We show that, with obstructive monitoring, the optimal output schedule is distorted in all directions—the high‐cost agent produces less, and the low‐cost agent produces more than the first‐best levels. Moreover, if the principal has a choice, she will make monitoring deliberately obstructive, because when monitoring is obstructive, although the agent's productivity decreases, his information rent is extracted more effectively. We also show that obstruction is optimal even when the principal is unable to commit to her monitoring strategy ex ante.
Sarcopenia and myosteatosis in patients undergoing curative radiotherapy for head and neck cancer: Impact on survival, treatment completion, hospital admission and cost
Authors: Findlay M. , Brown C. , De Abreu Lourenço R. , White K. , Bauer J. 
Published: July 2020

AbstractBackgroundComputed tomography (CT) is the gold standard of body composition analysis at the tissue‐organ level. The present study aimed to determine the impact of CT‐defined sarcopenia and myosteatosis on outcomes, including overall survival, unplanned hospital admissions and related costs, in patients who had completed treatment of curative intent for head and neck cancer (HNC).MethodsRetrospective observational study of patients undergoing radiotherapy of curative intent ± other treatment modalities for HNC. Tissue density data derived at the third lumbar vertebra (L3) were evaluated with sarcopenia defined per sex‐specific published threshold values for skeletal muscle index, stratified by body mass index and mean skeletal muscle attenuation in HU (Hounsfield units).ResultsPre‐ or post‐treatment images were available for 79/98 patients (80.6%) and 61/98 patients (62.2%), respectively. Sarcopenia was present in 42/79 patients pre‐treatment and 36/61 patients post‐treatment, whereas myosteatosis was present in 63/79 patients pre‐treatment and 48/61 patients post‐treatment. In patients with pre‐ and post‐treatment images (n = 60), the median (range) percentage weight change was −8.5% (−29.9 to +11.7). On multivariable analysis, a post‐treatment sarcopenia hazard ratio of 3.87 (95% confidence interval = 1.22–12.24, P = 0.021) and a pre‐treatment myosteatosis hazard ratio of 8.86 (95% confidence interval = 1.12–69.88, P = 0.038) were independent predictors of reduced overall survival. There was no difference in radiotherapy or chemotherapy treatment completion based on pre‐treatment sarcopenia status. The mean (SD) difference unplanned hospital admission cost was $15 846 ($17 707) for patients without sarcopenia versus $47 945 ($82 688) for patients with sarcopenia at any time point (P = 0.077).ConclusionsAs CT‐defined sarcopenia and myosteatosis hold clinically meaningful prognostic value, muscle status evaluation is recommended in routine clinical practice.
“We Don't Exactly Fit In, but We Can't Opt Out”: Gay Fathers' Experiences Navigating Parent Communities in Schools
Authors: Goldberg Abbie E. , Allen Katherine R. , Carroll Megan 
Published: July 2020

AbstractObjectiveThis qualitative study, which was guided by an integrative theoretical lens incorporating ecological, intersectional, and minority stress frameworks, examined the heteronormative and gendered contexts of gay fathers' relationships with other parents in their children's schools.BackgroundParents' interactions with other parents in the school environment can be a source of support, connection, tension, and/or alienation, and are significant to parents' overall school involvement, which in turn has implications for child academic and psychosocial adjustment. Little work has examined gay fathers' experiences in schools, and with other parents specifically, despite the potential salience of their gender and sexuality.MethodThe sample consisted of 40 gay fathers from 20 couples with adopted elementary school‐aged children (M = 9 years). The in‐depth interviews were analyzed via thematic analysis.ResultsFour main themes were evident: (a) school environments are heteronormative, homonormative, and gendered domains that gay fathers must navigate; (b) parent communities in schools are sometimes sites of disconnection, exclusion, and hostility around intersections among gender and sexuality, and race and class; and (c) parent communities in schools are also environments in which gay fathers experience connection, inclusion, and social support despite the prevalence of stigma.ConclusionThe school parent community is an important microcosm for children's academic and psychosocial outcomes. These gay fathers, who were actively involved in their children's schools, experienced both inclusion and exclusion in this heteronormative, gendered context. Their intersections of privilege and marginalization reveal the need to change institutional norms and advocate on behalf of diverse families in the educational environment.