bluuebunny/crossref_metadata_2025_split huggingface dataset:
KAJIAN PENGGUNAAN METODE IP, STORET, dan CCME WQI DALAM MENENTUKAN STATUS KUALITAS AIR
Authors: Romdania Yuda , Herison Ahmad , Susilo Gatot Eko , Novilyansa Elza 
Published: February 2020

Pemantauan kualitas air perlu dilakukan pada air sungai, laut, danau, rawa dan tanah sehingga dapat dimanfaatkan sesuai dengan kegunaannya bagi makhluk hidup. Kajian ini bertujuan untuk membandingkan beberapa metode perhitungan indeks kualitas air yang paling efektif, sensitif dan obyektif dalam menentukan status kualitas air permukaan. Metode perhitungan Indeks Kualitas Air (IKA) diperlukan untuk menyederhanakan banyaknya nilai dari berbagai jenis parameter menjadi sebuah angka tunggal yang mampu mendeskripsikan kualitas air, sehingga lebih mudah dipahami oleh masyarakat. Perhitungan IKA dengan menggunakan metode Storet, IP, dan CCME WQI (Canadian Council of Ministers of The Environment) dilaksanakan di beberapa penelitian di berbagai negara. Kajian ini akan membandingkan hasil literatur dari penelitian IKA di beberapa negara. Metode tersebut akan dibandingkan dengan beberapa indikator. Hasil kajian menunjukkan Metode IP lebih unggul jika memakai data tunggal karena memiliki kelebihan dari segi biaya dan waktu, namun hanya mempresentasikan status mutu air pada saat itu saja, tidak dalam periode tertentu. Metode Storet dan CCME menggunakan data perulangan sepanjang waktu (time series data) sehingga menggambarkan status mutu air dalam periode tertentu. CCME WQI lebih unggul dari Metode Storet dan Metode IP karena memperhitungkan besarnya selisih hasil pengujian yang melebihi baku mutu melalui F3 (Amplitude). Dari kajian di atas disimpulkan, Metode CCME merupakan metode yang paling tepat untuk menganalisis kualitas air baik pada air permukaan maupun air tanah dengan tingkat efektivitas dan sensitivitas yang lebih tinggi dibandingkan dengan metode lainnya serta penggunaan jumlah dan jenis parameter yang fleksibel.
Implementasi Penataan Ruang di Kawasan Dataran Tinggi Dieng Kabupaten Banjarnegara
Authors: Mukaromah Vina Fadhrotul , Handoyo Joni Purwo 
Published: February 2020

Dataran Tinggi terletak di 6 wilayah, yaitu Banjarnegara, Wonosobo, Pekalongan, Batang, Temanggung, dan Kendal. Kawasan yang diprioritaskan berada di Kabupaten Banjarnegara. Pemrioritasan ini didasarkan pada potensi kerusakan lingkungan dan pemanfaatan ruang di dalamnya. Penelitian ini bertujuan untuk menganalisis kondisi penggunaan lahan eksisting beserta peruntukan ruang kawasan sesuai RTRW Kabupaten Banjarnegara Tahun 2011-2031. Selain itu, dianalisis juga kesesuaian antara keduanya, berpedoman pada kriteria dalam Permen ATR/BPN Nomor 6 Tahun 2017 beserta faktor-faktor yang menyebabkan. Metode yang digunakan adalah metode kualitatif. Kondisi eksisting diinterpretasi melalui Citra Quickbird dan survey lapangan. Hasil penelitian menunjukan 11 jenis penggunaan lahan eksisting yang teridentifikasi dengan luasan terbesar kebun sayur dan ada 10 jenis peruntukan ruang dengan luasan terbesar lahan pertanian hortikultura. Tingkat kesesuaian keduanya tergolong tinggi. Dari kriteria jenis dan besaran, ketidaksesuaian memiliki persentase sebesar 9,36%. Dari segi dampak, pemanfaatan ruang menimbulkan dampak lokal dan regional. Kondisi ini dipengaruhi oleh faktor alami, faktor sosial, serta faktor lainnya (faktor teknis dan faktor regulasi).
Kata-Kata Kunci : penggunaan lahan, peruntukan ruang, implementasi penataan ruang
MEMAHAMI PERTALIAN DESA PAKRAMAN DI BALI DENGAN KARANG AYAHAN SEBAGAI BAGIAN DARI PALEMAHAN BERDASARKAN KONSEP TRI HITA KARANA
Authors: Wiguna Made Oka Cahyadi 
Published: February 2020

Desa Pakraman in Bali is included in the category of territorial customary law community and at the same time religious customary law community. On that basis, it should be understood that actually desa pakraman has autonomy in regulating the order of life and social life of its members. The existence of desa pakraman in Bali is very much needed for its members, as an institution that has the authority to regulate the life arrangements of indigenous law communities, including regulating, management, designation, maintenance and preservation of karang ayahan as the customary land of desa pakraman. The existence of karang ayahan is very dependent on the existence of a desa pakraman. Mastery of karang ayahan by krama desa who has the right, is used as a place of residence or other interests with the obligation to pay attention to certain general provisions set by desa pakraman in awig-awig and perarem. Besides that, the karang ayahan is also an integral part of the territory or wewengkon of a desa pakraman. For village people, the area is an important part of sovereignty from a desa pakraman that must be maintained.

Keywords: the existence of desa pakraman, the function of the karang ayahan
Implementasi Pengawasan dan Pengendalian Minuman Beralkohol Melalui Cukai Di Kabupaten Sleman
Authors: Wicaksono Tio Tegar 
Published: February 2020

Tujuan dari penelitian ini adalah untuk mengetahui upaya yang dilakukan oleh Kantor Pengawasan dan Pelayanan Bea dan Cukai Yogyakarta dalam mengawasi dan mengendalikan minuman beralkohol melalui cukai di Kabupaten Sleman, juga untuk mengetahui kendala yang ditemui dalam melakukan pengawasan serta solusi untuk mengatasi hambatan tersebut.
Metode penelitian yang digunakan dalam penulisan hukum ini adalah normatif empiris dengan sifat deskriptif. Penelitian ini diawali dengan penelitian kepustakaan untuk memperoleh data sekunder dilanjutkan dengan penelitian lapangan untuk memperoleh data primer. Data yang diperoleh dari hasil penelitian kepustakaan dan lapangan dianalisis secara kualitatif. Hasil analisis data kemudian diuraikan secara deskriptif.
Kesimpulan dari hasil penelitian penulis adalah: PERTAMA, pengawasan dan pengendalian dilakukan melalui pencegahan dan penindakanberupa kegiatan intelijen, operasi pasar dan ketiga bekerjasama dengan instansi lain. KEDUA, hambatan yang terjadi adalah belum maksimalnya peran masyarakat, kurangnya personel yang bertanggungjawab langsung terhadap pengawasan minuaman beralkohol, kurangnya koordinasi antara instansi pemerintah daerah, dan kualitas informan di tingkat penjual yang belum kuat.
Augmented Reality untuk Sistem Pernafasan pada Manusia
Authors: Amalia Eka Larasati , Suryani H Dhebys 
Published: February 2020

Teknologi maju dengan cepat karena banyak hal yang tidak mungkin beberapa tahun yang lalu menjadi mungkin sekarang. Augmented Reality adalah sintetis, realitas simulasi komputer atau rekreasi dari lingkungan waktu-nyata di mana pengguna dapat berinteraksi dengan lingkungan nyata yang direplikasi
Biologi hanya diajarkan dengan cara konvensional melalui buku sehingga membuat siswa hanya memperhatikan teks dan gambar. Untuk menarik minat mereka, pelajaran akan menjadi lebih menarik dan interaktif jika siswa dapat melihat proses secara langsung dalam bentuk 3D sebagai itu membuat siswa menghafalkannya dengan nyaman. Sistem pernapasan dan sirkulasi darah adalah contoh dari Biologi untuk kelas dua SMP. Dengan menerapkan Augmented Reality, mereka dapat mengambil pelajaran secara interaktif melalui objek digital dalam kenyataan.
Desain Augmented Reality dalam sistem pernapasan dan sirkulasi darah untuk siswa SMP dibuat dengan aplikasi Blender. Pembuatan aplikasi AR dengan platform android menggunakan kesatuan engine game. Berdasarkan uji fungsional yang dilakukan oleh para peneliti, dapat disimpulkan bahwa dengan menerapkan aplikasi tersebut, pengguna dapat memperoleh informasi terkait sistem pernapasan dan sirkulasi darah manusia yang dapat disampaikan secara menarik dan interaktif kepada para siswa
Identification of KIF23 as a prognostic signature for ovarian cancer based on large scale samples and clinical validation
Authors: Hu Yuexin , Zheng Mingjun , Wang Caixia , Wang Shuang , Gou Rui , Liu Ouxuan , Li Xiao , Liu Juanjuan , Lin Bei 
Published: February 2020

Abstract
Background: Ovarian cancer is one of the common malignant tumors in gynecology. Although the treatment strategy for ovarian cancer has been greatly improved in recent years, due to the metastasis, recurrence and drug resistance, the 5-year overall survival rate of patients is still less than 47%. However, at present, there is no specific markers for clinical application. The purpose of this study is to verify the expression and clinical significance of KIF23 in ovarian cancer and identify potential targets for the clinical treatment of ovarian cancer. Methods: The expression of KIF23 in ovarian cancer tissues and its relationship between survival prognosis and clinical pathological parameters were analyzed in Oncomine, GEO, and TCGA databases. KIF23 expression was analyzed by Kaplan-Meier plotter database and its relationship with chemo-resistance was studied. The molecular mechanism involved in KIF23 was analyzed from the perspective of gene mutation, copy number variation and other genomics. Finally, immunohistochemistry experiment was used to verify the expression of KIF2, and its relationship between the clinical pathological parameters and prognosis of ovarian cancer patients was analyzed by single factor and multivariate Cox regression models. Results: Bioinformatic and experimental results have demonstrated that KIF23 is highly expressed in ovarian cancer, and its high expression is positively correlated with poor prognosis. Overexpression of KIF23 can cause chemotherapy resistance in ovarian cancer and affect the overall survival of patients. Genomics analysis showed that KIF23 expression was associated with mutations such as FLG2 and TTN, and it was significantly enriched in tumor signaling pathways such as DNA replication and cell cycle. Conclusions: KIF23 can not only be used as a biomarker of poor prognosis in patients with various stages of ovarian cancer, but also be used as a molecular targeted drug and an independent prognostic biomarker for the treatment of ovarian cancer patients.
Integrated analysis of long non-coding RNA and mRNA expression in endometrial stromal cells induced by poly (I:C) identifies immune response genes
Authors: Zhang Ming , Zhang Yan , Wu Qiuying , Xu Ling , Zeng Yutian , Lu Chuanzhi , Ren Yan , Wang Zhicheng , Zhou Guangbin , Zeng Changjun , Zuo Zhicai , Song Tianzeng 
Published: February 2020

Abstract
Background The uterus of an animal is relatively easily infected by pathogenic microorganisms, which can cause serious reproductive disorders and economic loss to animal husbandry. The presence of long noncoding RNA (lncRNA) is closely related to many diseases. Poly(I:C) is a synthetic double-stranded RNA that is often used as a substitute for dsRNA viral infection. In this study, we analyzed the mRNA and lncRNA expression profiles of in vitro cultured rabbit endometrial stromal cells (ESCs) after poly(I:C)-induction, to explore the role of these RNAs in the immune response. Results We identified 10,927 lncRNAs and 20,494 mRNAs, of which 291 lncRNAs and 1311 mRNAs were significantly differentially expressed (DE) between the control and poly(I:C) groups ( p <0.05). GO and KEGG analysis showed that DE genes and target genes of DE lncRNAs were enriched in relation to the occurrence of various diseases, development of tissues and organs, metabolic processes, and the immune response. Moreover, these genes were also enriched in many pathways related to immune and inflammatory responses, such as the toll-like receptor and the NF-κB and Jak-STAT signaling pathways. Co-expression analysis of lncRNA and mRNA revealed that there were significant relationships between a number of lncRNAs including MSTRG.153189.1, MSTRG.102664.8, MSTRG.39626.1, MSTRG.68469.1, MSTRG.137189.4, MSTRG.32118.5 and MSTRG.76080.1, and the immune system genes, CCL2, CCL5, IL-1, IL-6, IFN and ISG15, which suggested that lncRNAs in ESCs might be involved in regulation of the immune response to poly(I:C) through genes related to immune signaling pathways. Conclusions Our results provide both transcriptomic and epigenetic insights into the immune response of uterine cells to dsRNA virus infection. Comprehensive lncRNA and mRNA transcriptomes in rabbit ESCs exposed to poly(I:C) were profiled. Co-expression analysis identified an integrated lncRNA-mRNA interaction network, implying that key genes or lncRNAs exerted critical influences on the immune response to virus infection.
Omics-based identification of shared and gender disparity routes in Hras12V-induced hepatocarcinogenesis: an important role for Dlk1-Dio3 genomic imprinting region
Authors: Li Huiling , Zhang Jing , Dong Jianyi , Zheng Xu , Lei Chuanyi , Wang Hong , Zhang Nan , Liu Yang , Luo Xiaoqin , Chen Jun , Wang Jingyu , Wang Aiguo 
Published: February 2020

Abstract
Background: The phenomenon of gender disparity is very profound in hepatocellular carcinoma (HCC). Although previous research has revealed important roles of microRNA (miRNA) in HCC, there are no studies investigating the role of miRNAs in gender disparity observed hepatocarcinogenesis. Results: In the present study, we investigated the global miRNAomics changes related to Ras -induced male-prevalent hepatocarcinogenesis in a Hras12V -transgenic mouse model ( Ras -Tg) by next-generation sequencing (NGS). We identified shared by also unique changes in miRNA expression profiles in gender-dependent hepatocarcinogenesis. 264 differentially expressed miRNAs ( DEMIRs) with q value ≤ 0.05 and fold change ≥ 2 were identified. A vertical comparison revealed that the lower numbers of DEMIRs in the hepatic tumor (T) compared with the peri-tumor precancerous tissue (P) of Ras -Tg and normal liver tissue of wild-type C57BL/6J mice (W) in males indicated that males are more susceptible to develop HCC. The expression pattern analysis revealed 43 common HCC-related miRNAs and 4 Ras -positive-related miRNAs between males and females. By integrating the mRNA transcriptomic data and using 3-node FFL analysis, a group of significant components commonly contributing to HCC between sexes were filtered out. A horizontal comparison showed that the majority of DEMIRs are located in the Dlk1-Dio3 genomic imprinting region (GIR) and that they are closely related to not only hepatic tumorigenesis but also to gender disparity in hepatocarcinogenesis. This is achieved by regulating multiple metabolic pathways, including retinol, bile acid, and steroid hormones. Conclusions: In conclusion, the identification of shared and gender-dependent DEMIRs in hepatocarcinogenesis provides valuable insights into the mechanisms that contribute to male-biased Ras -induced hepatic carcinogenesis.
Large-scale integrated evaluation of salt tolerance in japonica rice at the germination stage
Authors: Jing Xiu , Mi Ping , Xie Xianzhi , Wang Baoshan 
Published: February 2020

Abstract
Background: Salt stress, one of the most important abiotic stresses, severely reduces crop yields. Identifying salt-tolerant rice germplasm resources at the germination stage, developing salt tolerance indicators, and cultivating salt-tolerant rice cultivars are crucial for improving rice production in saline soil.Results: We measured the germination parameters of 140 japonica rice cultivars on the 7 day after sowing (DAS) in 0 and 150 mmol L−1 NaCl. To accurately assess salt tolerance and identify reliable indicators of salt tolerance, we measured the shoot length (SL), root length (RL), root fresh weight (RFW), shoot fresh weight (SFW), total fresh weight (TFW) and salt tolerance (STI) index after 7 days of salt-stress treatment. The 140 rice cultivars were divided into four categories based on the mean MFVs: highly salt tolerant (HST: 19 cultivars), salt tolerant (ST: 74 cultivars), weakly salt tolerant (WST: 43 cultivars), and salt sensitive (SS: 4 cultivars). Based on the physiological indicators, we established a mathematical model to accurately evaluate salt tolerance in japonica rice cultivars. STI of TFW under 150 mmol L−1 NaCl treatment showed the highest correlation with salt tolerance during the germination stage.Conclusions: We determined the optimum NaCl concentration (150 mmol L−1) for evaluating salt tolerance in japonica rice at the germination stage. We identified 19 HST, 74 ST, 43 WST, and 4 SS japonica rice cultivars during the germination stage and proposed a mathematical model to evaluate salt tolerance. STI of TFW is a reliable, accurate indicator for evaluating salt tolerance in japonica rice. These findings should greatly facilitate the evaluation of japonica rice cultivars during seed germination and the breeding of salt-tolerant rice cultivars.
Three-dimensional versus two-dimensional derived strain echocardiography for assessing right ventricular myocardial deformation in patients with chronic left ventricular heart failure: A proof-of-concept study
Authors: Gao Fei , Liu Chong , Guo Qiang , Jiang Shuang-quan , Wang Zhen-zhen , Liu Li , Li Hai-Ru , Du Guo-Qing , Tian Jia-wei 
Published: February 2020

Abstract
Background A novel three-dimensional echocardiography (3DE)-derived strain analysis software specialized for right ventricular (RV) monitoring is emerging that could definitely evaluate RV free wall and interventricular septum longitudinal strain. The aim of this study was to compare the diagnostic performance in evaluating RV function between 3DE and two-dimensional echocardiography (2DE)-derived longitudinal strain. Methods Echocardiographic examinations were performed in 82 patients with RV dysfunction associated with chronic left-sided heart failure and 40 control subjects. RV dysfunction was defined as a 3DE-derived RV ejection fraction (EF) <45%. Both 2DE and 3DE-derived strain analyses were performed in all the patients to measure the longitudinal strain of RV. Results 3DE-derived peak systolic longitudinal strain of RV free wall (RV-fwLS) was significantly lower in patients with RV dysfunction compared to control subjects (-14.0±4.1 vs. -26.7±4.7%; p<0.001), and it correlated well with cardiac magnetic resonance-derived RVEF (r=0.74, p<0.001). On receiver operator characteristic analysis, a 3DE-derived RV-fwLS cutoff value of >-21.1% was most useful in identifying patients at higher risk of RV dysfunction (sensitivity: 90% and specificity: 85%), also higher than 2DE-derived strain parameters. Additionally, RV dysfunctional patients with pulmonary hypertension (PH) had significantly reduced 3DE-derived RV-fwLS value than the subgroup without PH (-13.1±3.8 vs. -15.0±4.2; p<0.05). Conclusion Assessment of RV myocardial function by 3DE-derived longitudinal strain is better than 2DE in identifying patients with impaired RV systolic function. 3DE-derived strain analysis for RV should be considered as a complementary tool for assessing RV systolic function in terms of accuracy.
A rare case of maxillary ameloblastoma with lung metastasis: a case report
Authors: Sohal Karpal Singh , Mlaga Salvatory M , Vuhahula Edda A 
Published: February 2020

Abstract
Background

Ameloblastomas are low-grade neoplasms of odontogenic epithelium that account for about 1% of all oral tumours and about 10% of odontogenic tumours. Rarely, these tumours have a potential of distance metastasis, and once they do metastasize, they are termed as metastatic ameloblastoma.

Case presentation

A 24-year-old African man presented with a massive swelling on the right side of the face for 2 years in 2018. He was previously operated for a swelling in the right side of the maxilla in 2012, which was histologically diagnosed as ameloblastoma. Clinical and radiological evaluation revealed a massive maxillary tumour that had a local extension to the brain. X-ray and CT scan of chest pointed out to metastatic mass in the lungs. Histology of the recurrent tumour mass revealed it to be follicular ameloblastoma and CT-guided fine-needle aspiration cytology of the lung mass showed microscopic features of ameloblastoma similar to primary jaw tumour.

Conclusion

A Close and long-term follow-up is mandatory in patients diagnosed with ameloblastoma even years after primary resection.
WITHDRAWN: Pharmacist-led interventions might improve quality of life among older adult patients receiving warfarin treatment in rural areas: results from a randomized controlled trial
Authors: Falamić Slaven , Hadziabdic Maja Ortner , Lucijanić Marko , Marušić Srećko , Vrca Vesna Bačić 
Published: February 2020

Abstract
Background: Available literature supports the role of a pharmacist in the management of patients on warfarin therapy. However, randomized controlled trials on the influence of pharmacists’ interventions on the quality of life (QoL) in elderly patients on warfarin are missing. The aim of this study was to investigate the effect of pharmacists’ interventions on QoL of older adult patients receiving warfarin therapy in rural areas. The study aimed also to explore factors influencing QoL in these patients. Methods: We conducted a prospective randomized trial in a community pharmacy setting in a rural area. Eligible patients were randomized into intervention and control groups. Repeated education and a follow up plan were provided to the participants in the intervention group, and, if needed, pharmacist intervened to optimize warfarin therapy in collaboration with GP. QoL was measured using the DASS (Duke Anticoagulation Satisfaction Scale) questionnaire in both groups after 6 months. Results: In total, 131 participants finished the study (median age 73 years; 51.1% men). Participants in the intervention group scored significantly lower in all 3 domains of the DASS questionnaire at 6 months, namely limitations, hassles and burden, and psychological impact, as well as in overall scores (median score 86.5 and 66.0 in control and intervention group, respectively; p<0.001), indicating higher QoL in the intervention group. Adverse drug reactions (ADRs) and pharmacist’s intervention were predictive of QoL (r 2 =65.5%, P<0.001). Experience of ADRs was the strongest negative predictor of QoL (P<0.001). Conclusions: The study demonstrated that pharmacist’s intervention had positive impact on the QoL among older adult patients in rural areas. ADRs and pharmacist’s intervention were identified as predictive factors for QoL, whereby experience of ADRs was the strongest negative predictor. These results suggest that older adult patients receiving warfarin in rural areas could benefit from a community pharmacist intervention.