bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case discussions using WeChat: Are they reliable?
Authors: Li Yongwei , Hu Shugang , Alkhatatbeh Tariq , Wang Jialin , Song Jidong , Ma Rui , Wang Wei 
Published: January 2020

Abstract
Background : At present, more and more clinicians in China are partaking in case discussions using WeChat groups for the purposes of communication, diagnosis, treatment planning, and information sharing. However, the reliability of discussions using WeChat groups remains debatable. This study aimed to analyze case discussions in WeChat groups and evaluate their significance. Methods : By taking screenshots of the chat records from the most-used WeChat groups by orthopedic surgeons, all of the data related to the cases were collected from June to August in 2019. We analyzed the purpose, participation, and completeness of each case. Furthermore, we analyzed whether the conclusion reached in each case discussion, which was supported by the majority of members, was consistent with the opinion of three experts after evaluating all of the data from the case records. Results : Seven WeChat groups and 60 cases were included. WeChat group members often discussed cases to show surgical results (40.0%), to obtain treatment advice (39.0%), and to seek diagnostic advice (9%). The rate of ‘likes’ for ‘surgical results show’ was greater than the rate of ‘likes’ for alternative purposes (P<0.05). The percentage of complete, relatively complete and incomplete cases was 23%, 32%, and 45%, respectively. The relatively complete cases received more effective comments than the other cases (P<0.05). The cases for diagnostic purposes were more complete than those for other purposes (P<0.05). Among 60 cases, only 29 cases led to the same conclusions being reached among the three experts and WeChat group members. The consistency rate of conclusions relating to treatment was higher than that associated with the other purposes (P<0.05). The consistency rate of the complete cases was higher than that of the relatively complete and incomplete cases (P<0.05). Conclusions : Clinicians should treat discussions in WeChat groups for clinical decision-making with caution. Online discussions using WeChat groups should be standardized in respect to the cases presented and the comments that are generated.
Impact of patient-perceived quality of primary health care on the patients' bypass behaviour in China
Authors: Zhang WeiWei , Huang Yuankai , Li Gaojie , Zhou Hongjie , Xi Xiaoyu 
Published: January 2020

Abstract
Background Patient bypass often occurs under the loose gatekeeper system. Additionally, patients’ perceived quality of primary health care (PHC) is one of the important factors affecting bypass behaviour. Objective to explore individuals’ bypass behaviour in China and the associations between patients’ perceived quality of PHC and their bypass behaviour. MethodIn 2019, this study investigated Chinese bypass behaviour and the potential influencing factors. The questionnaire that was used assessed the following: the perceived quality of primary care using the Primary Care Assessment Tool; bypass experience; age; health insurance; and other factors. A logit regression model was used to analyse the impact of perceived quality of PHC on bypass behaviour. Results The data of 2070 residents in 706 health care facilities in China were collected. The results show that perceived quality of PHC is significantly associated with bypass behaviour in China. After adjustments were made for patients’ sociodemographic and other characteristics, an increase of one standard deviation (SD; odds ratio (OR) per 1-SD increase) in the PCAT scores led to a 2% decrease in bypass behaviour (OR 0.98, p<0.05). Gender, hukou and cold fee for PHC were negatively associated with bypass behaviour. Conclusion Patients' perceptions of PHC service quality play an active role in reducing their bypass behaviour, which may provide a new perspective for the design of PHC health policies.
Genomics of tailless bacteriophages in a complex lactic acid bacteria starter culture
Authors: Alexeeva Svetlana , Liu Yue , Zhu Jingjie , Kaczorowska Joanna , Kouwen Thijs R. H. M. , Abee Tjakko , Smid Eddy J. 
Published: January 2020

Abstract
Background Our previous study on a model microbial community originating from artisanal cheese fermentation starter revealed that bacteriophages not only co-exist with bacteria but also are highly abundant. To gain more insight into the potential role of prophages in the microbial community, we analysed the genomic content of 6 phage crops released by different strains in the starter culture, performed comparative genome analysis, and demonstrated their roles in phage defence of respective hosts. Results The identified prophages belong to three different subgroups of the Siphoviridae P335 phage group. Remarkably, most analysed prophages show disruptions in different tail encoding genes, resulting in a common tailless phenotype. Furthermore, a number of potentially beneficial features for the host carried by prophages were identified. The prophages carry up to 3 different phage defence systems per genome that are functional in protecting the host from foreign phage infection. Conclusion We suggest that the presumably defective prophages are a result of bacteria-phage coevolution and convey advantages to host bacteria; knowledge on the ecological role of such (defective) prophages may contribute to a refreshed look in strain selection criteria in (dairy) industry.
Vertebroplasty in patients with prostate cancer raises skeletal morbidity characterized by bone loss
Authors: Lallier Julie , Buy Xavier , Barthelemy Philippe , Palussiere Jean , Brouste Véronique , Sargos Paul , Cazeau Anne-Laure , Hoepffner Jean-Luc , Houédé Nadine , Krakowski Ivan , Gross-Goupil Marine , Cazzato Robert , Roubaud Guilhem 
Published: January 2020

Abstract
Background: Prostate cancer (PCa) is associated with high skeletal morbidity especially vertebral compression fractures (VCF) occurring on bone loss. We aimed to characterize benign (bVCF) versus malignant VCF (mVCF), in PCa patients who underwent vertebroplasty, and describe respective populations. Methods: An observational retrospective study was conducted in two French cancer centers. Characterization of VCF was made using a composite criterion (bone scan, CT scan, MRI +/- bone biopsy). Results: From 2008 to 2016, 100 patients, mean age 73.5 (45-94) and 128 VCFs were reported: 66 (52%) mVCF and 62 (48%) bVCF. Among bVCF, 17 (27%) occured in bone metastatic patients. Among mVCF, 28 (42%) of bone metastases were purely osteolytic and 38 (58%) with osteolytic component. Regarding bVCF, continuous androgen deprivation therapy and high doses of corticosteroids (> 6 months, ≥7.5 mg/day prednisone equivalent) were given in respectively 85% and 24% of cases. Dual X-ray Absorptiometry was performed in 13% of pts. Vitamin D supplementation was prescribed in 38% of patients. Conclusion: These data suggest the necessary prevention of bVCF even in patients with bone metastases with consequences on patient management, while studies for bone targeted agents approval used skeletal related events with no definition of the cause, i.e. benign or malignant. Occurrence of bVCF is a rising concern since these pts are experiencing longer survival. Malignant VCF were mostly with osteolytic component, which constitutes one feature of rising dedifferentiated phenotype. Vertebroplasty may play a major role in these newly defined populations.
The Influence of Adipose-derived Stromal Vascular Fraction Cells on the Treatment of Knee Osteoarthritis
Authors: Tsubosaka Masanori , Matsumoto Tomoyuki , Sobajima Satoshi , Matsushita Takehiko , Iwaguro Hideki , Kuroda Ryosuke 
Published: January 2020

Abstract
Background Adipose-derived stromal vascular fraction (SVF) cells are a mixed cell population that includes cells with multilineage potential, similar to bone marrow-derived mesenchymal stem cells. Our purpose is to investigate the influence of SVF cells in patients with knee osteoarthritis (OA) and the short-term treatment effects. Methods Fifty-seven patients were enrolled and treated with intra-articular injection of 5.0×10 7 SVF cells into the knee joint between September 2017 and March 2018. All patients were followed up for 12 months or longer. Mean age at treatment and follow-up period were 69.4±6.9 years and 13.7±2.0 months, respectively. The mean preoperative HKA angle was 6.7±3.6°. SVF cells were prepared using the Celution®800/CRS system from the patients’ abdominal or breech subcutaneous fat. The mean SVF cell viability was 90.6±2.7%. Clinical evaluations were performed for range of motion, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), visual analog scale (VAS) for pain, and the Knee injury and Osteoarthritis Outcome Score (KOOS). Imaging evaluations, which included the HKA angle assessed via radiography, and T2 mapping value using a 3.0-T magnetic resonance imaging unit were also assessed. Both clinical and imaging evaluations were performed preoperatively, 1, 3, 6, and 12 months postoperatively, and compared among all timepoints (p<0.05). Results Knee extension angle at 6 and 12 months postoperatively was significantly better than the preoperative angle. Total WOMAC, VAS, and KOOS scores at 1, 3, 6 and 12 months postoperatively were significantly better than preoperative scores. There was no significant difference in HKA angle among the five time periods. T2 mapping values of lateral femur and tibia were significantly higher 12 months postoperatively than preoperatively. Conclusions The short-term clinical effects of intra-articular SVF cell injection on knee OA were excellent. Intra-articular SVF cell injection is a novel and innovative approach for treating patients with knee OA.
Dynamics on the field: A focused ethnographic study of pediatric pain management at four Ghanaian hospitals
Authors: Amponsah Abigail Kusi , Oduro Evans , Bam Victoria , Kyei-Dompim Joana , Ahoto Collins Kwadwo , Axelin Anna 
Published: January 2020

Abstract
BackgroundAs part of efforts to develop and implement a short course educational program on pediatric pain management, the current study sought to understand the culture and contextual factors that influence children’s pain management in order to improve the practice in pediatric care settings.MethodsGuided by Bourdieu’s theory of practice, a focused ethnographic study was conducted from October, 2018 to February, 2019. The study was contextualized at four Ghanaian hospitals among purposefully sampled nurses, physicians, hospitalized children and their families. During the 20-week study period, three ethnographers spent 144 hours conducting participant-observation sessions. Formal and informal interviews were held with participants in addition to review of hospital records. Results Analysis of the field data resulted in four themes. “Children’s pain expression and response of caregivers” described the disposition (habitus) of both children and caregivers to act in particular ways due to children’s incomplete health status (bodily capital) which caused them pain and also resulted in discomforting procedures. “Pharmacological pain management practices and attitudes” elucidated the use of analgesics as the mainstay disposition (habitus) in children’s pain management due to high level of respect (symbolic capital) given to such interventions on the pediatric units (field). “Managing pain without drugs” illustrated healthcare providers and family caregivers’ disposition (habitus) of using diverse nonpharmacological methods in managing children’s pain. “Communication and interaction between pain actors” depicted how children’s access to care givers (social capital) can serve as a powerful tool in influencing pediatric pain assessment and management disposition (habitus) on the pediatric units (field). ConclusionsThe habitus of pediatric pain actors toward pain assessment and management practices are influenced by various forms of capital (social, cultural, symbolic, bodily and economic) operating at different levels on the pediatric care field. Quality improvement programs that seek to enhance pediatric pain management should use the insights obtained in this study to guide the development, implementation and evaluation stages.
Psychological characteristics and associations between kidney transplant recipients and biologically related or unrelated living donors: a retrospective observational study
Authors: Park Hyewon , Lee Yujin , Jee Hee-Jung , Lee Heon-Jeong , Gwon Jun Gyo , Min Hyeonjin , Jung Cheol Woong , Kim Myung-Gyu , Cho Chul-Hyun 
Published: January 2020

Abstract
Background : Although recipients and donors in living kidney transplantation are exposed to psychological distress, including depression and anxiety during the pre-operative period, only a few studies have evaluated their psychological relationship. This study aimed at determining the psychological characteristics and correlation between transplant recipients and donors as well as at investigating it in relation to biologically related and unrelated donors. Methods : This retrospective study on living kidney transplantation at the Korea University Anam Hospital was conducted from April 2008 to June 2019. While participants’ personality patterns were assessed using the Minnesota Multiphasic Personality Inventory-2(MMPI-2), their mood states before transplantation were evaluated via both the State-Trait Anxiety Inventory (STAI) and The Center for Epidemiologic Studies Depression Scale (CES-D). Statistical analysis was performed using a paired t-test and Spearman’s correlation analyses. Results : The recipient group showed a significantly higher sub-score in hypochondriasis (t =-4.49, P=.0001), depression (t =-3.36, P=.0015), hysteria (t =-3.30, P=.0018), STAI-T (t =-2.14, P=0.0372), and CES-D (t =-3.93, P=.0003) than donor group. A comparison of the psychological association between the recipient and donor groups revealed a significant positive correlation in the STAI-S (r=.357, P=.009) and CES-D (r=.362, P=.008). When assessing the difference in correlation based on the biological relationship between the recipients and donors, there is a positive correlation in CES-D (r=.415, P=.0202) in biologically related donors and recipients. In biologically unrelated but emotionally related group, recipients’ STAI-S score and donors’ STAI-S (r=0.413, P=.163), STAI-T (r=.559, P=009) score is positively correlated, and recipients’ STAI-T score and donors’ STAI-S (r=.466, P=.033), STAI-T (r=.520, P=.016) score is also positively correlated. Besides, recipients’ CES-D and donors’ STAI-S (r=.529, P=.014) and STAI-T (r=.560, P=.008) score show a positive correlation. Conclusions : The study indicated that transplantation recipients suffered from a higher level of depression and anxiety compared to the donors before transplantation. The findings suggest that recipients are more depressive and anxious than donors, and psychological problems like depression and anxiety can be shared in living kidney transplantation donors and recipients, especially in biologically unrelated but emotionally related groups.
The efficacy of tamoxifen in the treatment of thin endometrium in frozen-thawed embryo transfer cycle
Authors: Ji Jingjuan , Luo Lihua , Huang Lingli 
Published: January 2020

Abstract
Background: Thin endometrium is known to adversely affect reproductive performance. There is no agreement about a consensus treatment on thin endometrium. Tamoxifen(TAM) has a positive effect on endometrium when used as ovulation induction agent. Little information is available regarding its use in patients with thin endometrium during frozen-thaw embryo transfer (FET) cycles. This study was designed to evaluate the effectiveness of TAM on women with thin endometrium in frozen-thaw embryo transfer cycles. Methods: A total of 345 thin endometrium women were retrospectively analyzed during their FET cycles. Among them 190 received TAM protocol (TAM 20 mg per day for 5 days) and 155 hormone replacement therapy (HRT) protocol (estradiol val­erate 6 mg/d for 14 to 21days). Endometrial thickness and pregnancy outcome were compared between the two groups. Result(s): The endometrial thickness in TAM group was significantly higher compared with HRT group. The clinical pregnancy rate, implantation rate, ongoing pregnancy rate and live birth rate were significantly higher in TAM group than HRT group. Conclusion(s): In patients of recurrent thin endometrium, tamoxifen treatment in endometrium preparation may be a successful alternative approach
Detailed experimental and numerical characterization of turbulent flow in components of a water treatment plant
Authors: Ragessi Ivan Matías , García Carlos Marcelo , Márquez Damián Santiago , Pozzi Piacenza Cecilia , Cantero Mariano Ignacio 
Published: January 2020

Abstract
This paper presents a detailed characterization of turbulence in the incoming flow to the clarification component of a water treatment plant, ‘Los Molinos’ (Córdoba, Argentina). The main problems were related to the presence of turbulent flow patterns throughout the treatment, affecting the proper development of the physical processes required for water clarification. Namely: (a) a poor hydraulic design that could produce a non-homogeneous spatial distribution of the flow, recirculation zones and flow stagnation, and a non-uniform discharge distribution among the sedimentation units as a result of different cross-sectional dimensions of the transverse-channel, and (b) high turbulence intensity that affect the flocs' size as well as the efficiency of the settling tanks and filters. Firstly, a detailed in-situ experimental characterization of the turbulent flow was undertaken. An acoustic Doppler velocimeter (ADV) was used to characterize the flow turbulence, whereas for discharge measurements and mean flow velocity field an acoustic Doppler current profiler (ADCP) was employed. Secondly, a numerical model, based on the Reynolds-averaged Navier–Stokes (RANS) equations and the - turbulence closure model, was validated with the experimental data. Finally, based on the results, a diagnosis and recommendations were made for the optimization of the hydraulic design of the water treatment plant.
Annotating Narrative Levels: Review of Guideline No. 7
Authors: Martens Gunther 
Published: January 2020

The guideline under review builds on the acquired knowledge of the field of narrative theory. Its main references are to classical structuralist narratology, both in terms of definitions (Todorov, Genette, Dolezel) and by way of its guiding principles, which strive for simplicity, hierarchy, minimal interpretation and a strict focus on the annotation of text-intrinsic, linguistic aspects of narrative. Most recent attempts to do “computational narratology” have been similarly “structuralist” in outlook, albeit with a stronger focus on aspects of story grammar: the basis constituents of the story are to some extent hard-coded into the language of any story, and are thus more easily formalized. The present guideline goes well beyond this restriction to story grammar. In fact, the guideline promises to tackle aspects of narrative transmission from the highest level (author) to the lowest (character), but also demarcation of scenes at the level of plot, as well as focalisation. Thus, the guideline can be said to be very wide in scope.
Requerimiento de hemostasia endoscópica en pacientes de una unidad de cuidado intensivo con hemorragia de vías digestivas altas
Authors: Medina Torres Daniel Eduardo , Otero Regino William , Otero Ramos Elder Ramiro 
Published: January 2020

Introducción: los pacientes hospitalizados en la unidad de cuidados intensivos (UCI) tienen riesgo de hemorragia digestiva alta (HVDA). La endoscopia digestiva alta (EVDA) es el examen de elección en esos pacientes y es diagnóstica y terapéutica. Muchas lesiones identificadas endoscópicamente no requieren tratamiento endoscópico. En Colombia no hay estudios sobre la prevalencia de las diferentes lesiones sangrantes digestivas altas en pacientes de la UCI, ni sobre la utilización de EVDA terapéutica en esos pacientes.
Materiales y métodos: estudio de corte transversal realizado en la Clínica Fundadores de Bogotá, Colombia, entre enero del 2003 a febrero del 2017. Se incluyeron pacientes adultos de la unidad de cuidado intensivo con EVDA indicada por HVDA.
Resultados: en el análisis final se incluyeron 156 EVDA. Los hallazgos fueron los siguientes: gastritis crónica 76,62% (118), esofagitis erosiva (grado A-grado D) 57,79% (89), gastritis erosiva 47,4% (73), duodenitis erosiva 21,43% (33), úlcera gástrica 18,18% (28), varices esofágicas 11,69% (18), úlcera duodenal 11,04% (17) y desgarro de Mallory-Weiss 4,55% (8). Solo el 15% de los pacientes requirió manejo endoscópico, incluidos los que tenían várices esofágicas.
Conclusión: en el presente estudio, el 15% de los pacientes con HVDA requirió tratamiento endoscópico. Se deben realizar trabajos prospectivos que permitan establecer factores de riesgo que puedan predecir la necesidad de EVDA terapéutica en pacientes con HVDA. Quien no tenga esos predictores se debe tratar empíricamente con IBP y evitar gastos innecesarios en EVDA diagnósticas.
Enfermedades hepáticas y embarazo
Authors: Toro Rendon Luis Guillermo , Correa Gutiérrez Elizabeth María , Calle Tavera Luisa Fernanda , Ocampo Mesa Adriana , Vélez Cuervo Sandra María 
Published: January 2020

La prevalencia de las enfermedades hepáticas en el embarazo no es despreciable, ya que estas se presentan en 3%-5% de todas las gestaciones. Entre las múltiples causas se encuentran cambios fisiológicos del embarazo; enfermedad hepática preexistente, siendo las más comunes las enfermedades colestásicas (colangitis biliar primaria y colangitis esclerosante primaria), hepatitis autoinmune, enfermedad de Wilson, hepatitis virales crónicas, cirrosis establecida de cualquier etiología y paciente con historia de trasplante hepático; enfermedad hepática adquirida durante el embarazo, siendo las principales las hepatitis virales, la toxicidad inducida por medicamentos y la hepatolitiasis; hepatopatía relacionada con el embarazo, en la cual se encuentran 5 entidades principales: hiperémesis gravídica, colestasis intrahepática del embarazo, preeclampsia, síndrome HELLP e hígado graso del embarazo.
La severidad de estas entidades tiene una amplia gama de presentaciones, desde la paciente que es completamente asintomática, hasta la falla hepática aguda e incluso la muerte. La gravedad del cuadro se asocia con una morbilidad y mortalidad significativas tanto para la madre como para el feto, lo cual hace que una evaluación rápida, diagnóstico certero y manejo apropiado por un equipo multidisciplinario (incluida obstetricia de alto riesgo, hepatología, gastroenterología y radiología intervencionista), en un servicio que tenga la posibilidad de ofrecer trasplante hepático, sean fundamentales para obtener buenos desenlaces.