bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the educational quality of lumbar puncture instruction videos on YouTube.
Authors: Busser Renee De , Groffi Marie , Hoffbauer Kathleen , Borght Elise Van der , Toelen Jaan 
Published: November 2019

Abstract
Background YouTube has become an important educational platform. For biomedical students the site is a primary information source for informational and instructional videos on a variety of medical topics.This study examined the educational quality of instructional lumbar puncture procedure videos on YouTube.Methods The search strings “lumbar puncture medical procedure” and “spinal tap medical procedure” were used. The first 100 videos for each search string were assessed for eligibility. Video characteristics were documented. To evaluate the popularity of the videos the Video Power Index was calculated. Four validated checklists were used for video assessment: Lumbar Puncture Assessment Tool, reliability score, Global Quality Score, Attractiveness and Understandability score.Results Lumbar puncture videos had a median ratio of 8,90 views/day, 0,04 likes/day and a video power index of 14,44, which was lower compared to other categories of instructional videos (CPR and cake baking). The mean LumPAT score was 34/55, with only three videos scoring at least 44/55, the pass ratio of this assessment. The median reliability score was 3/4, the median GQS 3/5 (moderate quality) and the median AU score 6,5/8. Significant correlations were found between the LumPAT score and the video length (p = 0,003), the GQS (p < 0,001) and the AU score (p = 0,01).Conclusions In this study, only three out of the 23 videos passed the LumPAT score. The majority of the instructional videos are not suitable for the training of health care professionals and students in performing a lumbar puncture procedure.
First line in psychiatric emergency: Pre-hospital emergency protocol for mental disorders in Iran
Authors: Shirzad Fatemeh , Hadi Fateme , Mortazavi Seyede Salehe , Biglari Maryam , Sari Hassan Noori , Mohammadi Zeinab , Atoofi Mehrdad Kazemzade , Shariat Seyed Vahid 
Published: November 2019

Abstract
Introduction This article is a report of designing a rapid and effective guide for paramedics who take care of patients in a pre-hospital setting to answer developing demands.Methods The relevant literature was reviewed, and the topics were extracted. Then, the extracted items were discussed in an expert panel. Finally, items were discussed in a meeting including emergency technicians and emergency technical assistants to identify implementation problems.Result Important topics for managing psychiatric patients were categorized at three levels: 1) Patient safety and security issues, 2) Patient status assessment and diagnosis, and 3) Patient management (medical, behavioral management, and referral to a treatment center).Discussion This protocol can be a solution to improve emergency technician training. Such summarized protocols can be used for rapid review immediately before exposure to a patient with an acute psychiatric condition. Due to specific cultural and different access to medicines in Iran, some issues (For instant, access to medications) are different.
Adapting wellbeing research tools for Aboriginal and Torres Strait Islander people with Chronic Kidney Disease
Authors: Nagel Tricia , Sweet Michelle , Dingwall Kylie , Puszka Stefanie , Hughes Jaqueline , Kavanagh David , Cass Alan , Howard Kirsten , Majoni Sandawana 
Published: November 2019

Abstract
Background There is an acute need to develop wellbeing measures and interventions that are appropriate for Aboriginal and Torres Strait Islander people, including residents of remote communities who have chronic physical conditions. The Kessler 10, Patient Health Questionnaire 9, and EuroQoL are valid, reliable, and commonly used tools to assess various aspects of wellbeing but have not yet been translated to Aboriginal and Torres Strait Islander languages. Similarly, the Stay Strong App is a brief, culturally responsive, e-mental health intervention, but has not been used with Aboriginal and Torres Strait Islander people with Chronic Kidney Disease. Methods We aimed to pilot test the above tools with Aboriginal and Torres Strait Islander Australians with Chronic Kidney Disease Stage 5 (CKD-5) and develop revised versions suitable for use in a clinical trial using a four-stage multi-method approach. Stage 1: Pilot testing of outcome measures and Stay Strong App intervention in a purposive sample of five haemodialysis patients and carers to examine acceptability. Stage 2: Translation of outcome measures through collaboration between the Aboriginal Interpreter Service, Aboriginal and Torres Strait Islander research officers and research team. Stage 3: Conversion of revised outcome measures to electronic format. Stage 4: Collaboration of research team and an Expert Panel in an iterative approach to adapt the Stay Strong App. Results Stage 1: Pilot testing of outcome measures identified three areas of difficulty: explanation of time frames and frequency responses, translation of the terms ‘worthless’ and ‘hopeless’, and fatigue and boredom related to the assessment process. Stage 2: Translation of most items was uncontroversial. Discrepancies between team member views and local interpretations of specific terms were addressed. Final drafts were forwarded to the Aboriginal Interpreter Service for translation. Stage 3: Audio translations in 11 languages were integrated into an interactive Outcome Measures App. Stage 4: A new renal version of the Stay Strong App was developed through research team and expert panel consensus. Conclusion The four-stage approach allowed adaptation of the tools for use within a future trial of wellbeing interventions for Aboriginal and Torres Strait Islander people receiving haemodialysis. Trial registration: ACTRN12617000249358 Registered 17 February 2017.
Prophylaxis with trimethoprim-sulfamethoxazole (TMP-SMX) decreases the incidence of interstitial pneumonia in B cell non- Hodgkin lymphoma patients receiving chemotherapy with rituximab
Authors: Li Cong , Lu Fangxiao , Tao Lei , Yu Haifeng , Chen Xi , Peng Shuailing , Han Shuiyun , Yang Haiyan 
Published: November 2019

Abstract
Several studies have reported incidence of interstitial pneumonia (IP) among patients with non-hodgkin lymphoma (NHL) receiving chemotherapy with rituximab, however the best prophylaxis method remains unclear. This retrospective study was intended to identify the effect of prophylactic TMP-SMX once daily on IP and high risk factors effecting IP in patients with NHL. From March 2013 to April 2018, 498 patients (264 male, 53%) with B cell NHL receiving first-line CHOP-like chemotherapy with rituximab were enrolled in this study. The median age of the patients was 56 years old. Among these patients, 311 patients (62.4%) received prophylaxis of TMP-SMX. IP occurred in 65 patients, so the incidence rate of IP was 13.1%. The prophylactic use of TMP-SMX given one tablet daily could significantly decrease the rate of IP from 21.4% to 8.0% (p<0.001). For 311 patients with prophylactic TMP-SMX, 2 (1.2%) had rashes, 38 (12.2%) suffered nausea and vomiting, 52 (16.7%) exhibited neutropenia, and 18 (5.8%) suffered kidney dysfunction. Being male, having a history of diabetes and not receiving TMP-SMX prophylactic therapy were considered as statistically significant risk factors for IP in univariate and multivariate analysis. Disease progression was observed in 55/311 (17.7%) patients with prophylactic TMP-SMX and in 63/187 (33.7%) patients without prophylactic TMP-SMX treatment (p<0.001). The present study concluded that IP occurrence is not rare in B cell non-hodgkin lymphoma patients receiving chemotherapy with rituximab, while prophylaxis of oral TMP-SMX given one tablet daily significantly decreased incidence of IP.
Effect of drought stress during soybean R2-R6 growth stages on sucrose metabolism and its transport from leaf to seed
Authors: Du Yanli , Zhao Qiang , Chen Liru , Yao Xingdong , Zhang Huijun , Zhang Bo , Wu Junjiang , Xie Futi 
Published: November 2019

Abstract
Background Sucrose is the main photosynthesis product of plants and the fundamental carbon skeleton monomer and energy supply for seed formation and development. Drought stress induces decreased photosynthetic carbon assimilation capacity and seriously affects seed weight in soybean. However, little is known about the relationship between decreases in soybean seed yield and disruption of sucrose metabolism and transport balance in leaves and seeds during the reproductive stages of crop growth.Results Three soybean cultivars with similar growth periods, ‘Shennong17’, ‘Shennong8’, and ‘Shennong12’ were subjected to drought stress during reproductive growth for 45 days. Drought stress significantly reduced leaf photosynthetic rate, shoot biomass, and seed weight. Drought stress changed the distribution of carbon assimilation products in leaves, thus decreasing starch content and increasing soluble sugar content. Drought stress increased the activities of sucrose phosphate synthase, sucrose synthase, and acid invertase enzymes, and up-regulated the expression levels of GmSPS1 , GmSuSy2 , and GmA-INV in leaves. Drought stress decreased the contents of starch, fructose, and glucose in seeds during the late seed filling stages, while it induced sucrose accumulated, which resulted in a decreased hexose-to-sucrose ratio. In developing seeds, the activities of sucrose synthesis and decomposition enzymes and the expression levels of genes related to metabolism were enhanced during early seed development under drought stress; however, under prolonged drought stress, all of them decreased. The expression levels of sucrose transporter genes in seeds were up-regulated under drought stress during early seed development, but down-regulated in leaves and seeds during the middle and late seed filling stages.Conclusion These results demonstrated that drought stress enhances the capacity for unloading sucrose into seeds and activated sucrose metabolism in seeds during early seed development. At the middle and late seed filling stages, sucrose flow from leaves to seeds was diminished, and the balance of sucrose metabolism was impaired in seeds, resulting in seed mass reduction. The different regulation strategies in sucrose allocation, metabolism, and transport during different seed development stages may be one of the physiological mechanisms for soybean plants to resist drought stress.
Comparative physiological and biochemical mechanisms of salt tolerance in five contrasting highland quinoa cultivars
Authors: Gao Qi , Cai Zhiquan 
Published: November 2019

Abstract
Background Chenopodium quinoa Willd., a halophytic crop, shows great variability among different genotypes in response to salt. To investigate the salinity tolerance mechanisms, five quinoa cultivars belonging to highland ecotype were compared for their seed germination (under 0, 100 and 400 mM NaCl) and seedling’s responses under five salinity levels (0, 100, 200, 300 and 400 mM NaCl).Results Substantial variations were found in plant size (biomass) and overall salinity tolerance (plant biomass in salt treatment as % of control) among the quinoa cultivars. Plant salinity tolerance was negatively associated with plant size, especially at lower salinity levels (<300 mM NaCl), but salt tolerance between seed germination and seedling growth is not closely correlated. Except for shoot/root ratio, all measured plant traits responded to salt in a genotype-specific way. Salt stress resulted in decreased plant height, leaf area, root length, and root/shoot ratio in each cultivar. With increasing salinity levels, leaf superoxide dismutase (SOD) activity and lipid peroxidation generally increased, but catalase (CAT) and peroxidase (POD) activities showed non-linear patterns. Organic solutes (soluble sugar, proline and protein) accumulated in leaves, whereas inorganic ion (Na + and K + ) increased but K + /Na + decreased in both leaves and roots. Across different salinity levels and cultivars, without close relationships with antioxidant enzyme activities (SOD, POD, or CAT), salinity tolerance was significantly negatively correlated with leaf organic solute and malondialdehyde contents and inorganic ion contents in leaves or roots (not root K + content), but positively correlated with K + /Na + ratio in leaves or roots.Conclusion Our results established that leaf osmoregulation, K + retention, Na + exclusion, and ion homeostasis are the main physiological mechanisms conferring salinity tolerance of these cultivars, rather than the regulations of leaf antioxidative ability. As an index of salinity tolerance, K + /Na + ratio in leaves or roots can be used for the selective breeding of highland quinoa cultivars.
A PILOT CLINICAL TRIAL TO MONITOR RESPONSE TO CHEMOTHERAPY USING THE CA-62 MARKER OF EPITHELIAL CARCINOMAS
Authors: Khakimova G. G. , Cherkasova Zh. R. , Tsurkan S. A. , Fedchikov G. A. , Suganov N. V. , Gorbunova V. A. 
Published: November 2019

The objective of the study was to assess the feasibility of using CA -62 marker of epithelial carcinomas for monitoring treatment response and detecting cancer progression or recurrence during chemotherapy.Material and Methods. A 12-month double-blind clinical trial was conducted by two independent groups: clinical oncologists and biochemists, and involved 89 patients with different cancers confirmed by histopathological findings. The other inclusion criteria were: the presence of at least one measurable lesion according to the RECIST criteria, ECOG performance status 0-2 and satisfactory laboratory parameters. The expression of CA -62 cancer marker was measured by immunochemiluminescent assay used for the detection of epithelial carcinomas.Results. The elevated level of CA -62 marker was observed in 76 patients before starting the treatment. After completion chemotherapy, the level of this marker decreased to the normal reference ranges (<4600 U/ml) in 53 % of patients and remained increased in 24 % of patients. Of 24 % of patients with the initial low level of CA -62 marker (1000–4000 U/ml) before treatment, 12 % had no changes in the level of this marker during chemotherapy; however, 5 % of these patients had disease progression and 7 % had stable disease after starting the treatment. In 12 % of patients with an initial low CA -62 level, it increased during chemotherapy, indicating disease progression.Conclusion. The changes in the level of CA -62 marker during chemotherapy in patients with gastric cancer, small-cell lung cancer, colorectal cancer, neuroendocrine cancer and ovarian cancer showed a high correlation (76–100 % depending on the tumor site) with the performance status of the patients according to RECIST criteria. The CA -62 marker was shown to be feasible for monitoring gastric cancer, small-cell lung cancer, colorectal cancer, neuroendocrine cancer and ovarian cancer as well as for assessing the response to chemotherapy.
Classic Palace Architecture of the Eastern Podillia in Ukraine: Historical Background and Key Factors
Authors: KHOROSHA Oksana , SMOLIAK Volodymyr 
Published: November 2019

Abstract
The article deals with the palace architecture of the style of classicism in the Eastern Podillia in Ukraine of the late 18th and early 20th centuries, in the context of historical and socio-political backgrounds. This issue remains poorly studied, because it was not considered comprehensively for Eastern Podillia. The purpose of the article is to establish the factors and historical preconditions of the architecture of the palace complexes in accordance with the world tendencies and regional features of Eastern Podillia. The complex of general scientific and special research methods was applied in the work. It was established, that the palace architecture of Eastern Podillia was formed dependent on socio-economic and political changes in society, a complex of the main factors and worldview-cultural desires of the owners of estates. Determined, that the principles of the European classicism had an impact on the creation of conceptual features and typical signs of the palace complexes of the Eastern Podilia in the context of regional architectural tendencies and belonging to the territory of the Polish-Lithuanian Commonwealth in the 18 century.
Development of Daphnia Magna Under Exposure to Ampicillin
Authors: VO Thi-My-Chi , PHAM Ngoc-Han , NGUYEN Tan-Duc , BUI Manh-Ha , DAO Thanh-Son 
Published: November 2019

Abstract
In this study, the chronic effects of Ampicillin on survival, reproduction and growth of Daphnia magna was monitored during 21 days exposure test. The results showed that Ampicillin strongly affected on life history traits of Daphnia magna, i.e. 47% reduction of survival proportion, lower 68% reproduction than the control, and reduction in body length and in the intrinsic population rate, especially at its highest concentration. The antibiotics especially Ampicillin should be included int the Vietnam guidelines for environmental and ecological protection.
COMPUTATIONAL DESIGN FOR THE PRESERVATION AND ENHANCEMENT OF HISTORICAL HERITAGE. A PREFABRICATED COVERING PROTOTYPE FOR ARCHAEOLOGICAL SITES IN RURAL CONTEXT
Authors: BEVILACQUA Marco Giorgio , IARDELLA Filippo , PALAZZUOLI Marco , CUADRADO Rodrigo Rubio 
Published: November 2019

Abstract
In Italy, many archaeological sites in peri-urban and rural areas are in a deep state of neglect, with unprotected remains and no prospects of enhancement. The paper shows the results of a study aimed at developing a parametric prototype of a prefabricated coverage, to be adapted to various conditions. The Roman Domus of the Acropolis of Populonia in the archaeological park of Baratti and Populonia in Tuscany was chosen as case study. The prototype was parametrically realized using heuristic algorithms based on natural selection (Genetic Algorithms), associated with multi-objective optimization criteria. The algorithm was conceived to optimize the support pillars’ position and the visiting path, in relation to the main points of interest of the archaeological site. The final product consists of a wooden structural covering with 11 steel circular-section pillars, completed with a casing made of wood slats and opaque white PVC sheets.
GRAPHICAL ANALYSIS OF HISTORICAL MAPS. TRACES OF INDUSTRIAL ARCHEOLOGY IN THE SOUTH-EASTERN SECTOR OF THE CITY OF CAGLIARI. (SARDINIA, ITALY)
Authors: PIRINU Andrea 
Published: November 2019

Abstract
The contribution proposed is a part of a research aimed at the definition of methodologies for the analysis and representation of the landscape of Sardinia, with particular reference to one of its most important and characteristic versions: the landscape of the wetlands. The history of the city of Cagliari is strongly linked to the sea and the lagoons, elements that constituted the authentic “settlement principle” where the lagoons, in particular, were sources of decisive resources as well as for fishing, for the landing (especially the western ponds) and salt extraction (mainly from the Molentargius pond). The case study consists in a part of the regional natural park Molentargius-Saline, a system of considerable environmental and landscape value that hosts examples of industrial archeology. Through a multi-scale approach that links traditional and IT tools it is possible to define some representative graphic models of the studied landscape in order to plan its protection and enhancement. The comparison between historical maps and aerial images here presented is the first step of a path of knowledge that explores, analyzes and wants to highlight the most important transformation that occurred in this area since the nineteenth century and a partial preservation of historical cultural landscape.
MULTI-VARIABLE OPTIMIZATION MODELS FOR BUILDING ENVELOPE DESIGN USING ENERGYPLUS SIMULATION AND METAHEURISTIC ALGORITHMS
Authors: GRYGIEREK Krzysztof , FERDYN-GRYGIEREK Joanna 
Published: November 2019

Abstract
The paper presents the method of optimal design of the building envelope. The influence of four types of windows, their size, building orientation, insulation of external walls, ceiling to unheated attic and ground floor on the life cycle costs in a single-family building in Polish climate conditions is analyzed. The optimization procedure is developed by means of the coupling between MATLAB and EnergyPlus. The results using three metaheuristic methods: genetic algorithms, particle swarm optimization, and algorithm based on teaching and learning are compared. The analyses have shown the possibility of reducing the life cycle costs through the optimal selection of the building structure. The high initial investment (above the required standard) pays off in the long run when using a building.
THE PRELIMINARY UNIAXIAL COMPRESSION BEHAVIOR OF CORRUGATED COLD FORMED STEEL MEMBERS
Authors: KILIÇ Mahmut , MAALI Mahyar , AYDIN Abdulkadir Cüneyt 
Published: November 2019

Abstract
The modern basic civil engineering concept is to design simplistic structures, by using innovative brand new manufacturing and assemblage concepts. As a result of this concept, arch type steel plates are used like the corrugated coatings. The main purpose of this work is to describe the Roll Form Machine (RFM) technology as used for the structures, especially for the roofs. Cold formed arch type steel structures may be fast and simple. These types of structures were used for temporary buildings in the US Army. Nowadays, this technology becomes popular and gets in consideration for civil life. However, the design concept of this technology does not have a theoretical model, and the calculations are evaluated according to the United States Standards. The uniaxial compressive behaviors of corrugated arch type steel members are observed, experimentally within this work.
ENERGY EFFICIENCY ECONOMICS OF CONVERSION OF BIOGAS FROM THE FERMENTATION OF SEWAGE SLUDGE TO BIOMETHANE AS A FUEL FOR AUTOMOTIVE VEHICLES
Authors: CIUŁA Józef , GASKA Krzysztof , ILJUCZONEK Łukasz , GENEROWICZ Agnieszka , KOVAL Viktor 
Published: November 2019

Abstract
The paper presents the analysis of efficiency and energy economics potential applicability of biomethane as an alternative fuel for powering company owned motor vehicles and public transport vehicles produced by the conversion of surplus biogas generated in municipal sewage treatment plants. Biogas produced at municipal wastewater treatment plants in the process of anaerobic fermentation of sewage sludge is a source of renewable energy used for energy generation. Currently in Poland, the most commonly applied management method of biogas produced from sewage sludge involves the production of energy in a cogeneration system. Having in mind the condition of the natural environment, the search for alternative fuels for motor vehicles is underway. One of the types that can be used is biomethane, produced by the conversion of biogas produced in the fermentation process of organic wastes contained in sewage sludge. The biogas purified to contain about 95% of methane can be used in vehicles designed to burn gaseous fuel. In order to implement the conversion process of biogas to biomethane, it is necessary to work out a balance sheet of biogas produced at the sewage treatment plant, to study its chemical composition and to select the optimal technology to obtain high-energy gas fuel that meets required standards. In the course of the biogas conversion process, carbon dioxide is removed, which is regarded here as the so-called energy ballast. The technology used for powering motor vehicles by means of biomethane has been successfully implemented in many countries of the European Union. In view of environmental considerations, the proposed solution is generally supported because biomethane-powered engines have lower levels of emissions harmful to people and the environment.