bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-Awareness Moderates the Association Between Executive Dysfunction and Functional Independence After Acquired Brain Injury
Authors: Villalobos Dolores , Caperos José M , Bilbao Álvaro , Bivona Umberto , Formisano Rita , Pacios Javier 
Published: June 2020

Abstract

Objective
Impaired self-awareness (SA) is a common symptom after suffering acquired brain injury (ABI) which interferes with patient’s rehabilitation and their functional independence. SA is associated with executive function and declarative memory, two cognitive functions that are related to participants’ daily living functionality. Through this observational study, we aim to explore whether SA may play a moderator role in the relation between these two cognitive processes and functional independence.

Method
A sample of 69 participants with ABI completed a neuropsychological assessment focused on executive function and declarative memory which also included a measure of SA and functional independence. Two separated linear models were performed including functional independence, SA, and two neuropsychological factors (declarative memory and executive function) derived from a previous principal component analysis.

Results
Moderation analysis show a significant interaction between SA and executive function, reflecting an association between lower executive functioning and poorer functional outcome, only in participants with low levels of SA. Notwithstanding, declarative memory do not show a significant interaction with SA, even though higher declarative memory scores were associated with better functional independence.

Conclusions
SA seems to play a moderator effect between executive function, but not declarative memory, and functional independence. Accordingly, participants with executive deficits and low levels of SA might benefit from receiving specific SA interventions in the first instance, which would in turn positively impact on their functional independence.
Predicting human microbe–drug associations via graph convolutional network with conditional random field
Authors: Long Yahui , Wu Min , Kwoh Chee Keong , Luo Jiawei , Li Xiaoli 
Published: June 2020

AbstractMotivationHuman microbes play critical roles in drug development and precision medicine. How to systematically understand the complex interaction mechanism between human microbes and drugs remains a challenge nowadays. Identifying microbe–drug associations can not only provide great insights into understanding the mechanism, but also boost the development of drug discovery and repurposing. Considering the high cost and risk of biological experiments, the computational approach is an alternative choice. However, at present, few computational approaches have been developed to tackle this task.ResultsIn this work, we leveraged rich biological information to construct a heterogeneous network for drugs and microbes, including a microbe similarity network, a drug similarity network and a microbe–drug interaction network. We then proposed a novel graph convolutional network (GCN)-based framework for predicting human Microbe–Drug Associations, named GCNMDA. In the hidden layer of GCN, we further exploited the Conditional Random Field (CRF), which can ensure that similar nodes (i.e. microbes or drugs) have similar representations. To more accurately aggregate representations of neighborhoods, an attention mechanism was designed in the CRF layer. Moreover, we performed a random walk with restart-based scheme on both drug and microbe similarity networks to learn valuable features for drugs and microbes, respectively. Experimental results on three different datasets showed that our GCNMDA model consistently achieved better performance than seven state-of-the-art methods. Case studies for three microbes including SARS-CoV-2 and two antimicrobial drugs (i.e. Ciprofloxacin and Moxifloxacin) further confirmed the effectiveness of GCNMDA in identifying potential microbe–drug associations.Availability and implementationPython codes and dataset are available at: https://github.com/longyahui/GCNMDA.Supplementary informationSupplementary data are available at Bioinformatics online.
Analysing phenotypic variation in barn swallows (Hirundo rustica) across China to assess subspecies status
Authors: Liu Yu , Scordato Elizabeth S C , Zhang Zhengwang , Evans Matthew , Safran Rebecca J 
Published: June 2020

AbstractPhenotypic variation is often used to delineate species and subspecies boundaries. Statistical analysis of phenotypic variation within a species is helpful both for understanding biodiversity and for its conservation. At least three named subspecies of barn swallows (Hirundo rustica) have distributions that span China, yet, to date, no systematic study of phenotypic differentiation has been applied to understand the delineation of these subspecies. In this study, we collected 510 samples of barn swallow from 23 populations in China, including two recognized subspecies, H. r. rustica and H. r. gutturalis, and one potential subspecies, H. r. mandschurica. With these samples, we examined and found morphometric and colour differences among different populations. Western Chinese barn swallows (H. r. rustica) have larger body size and could be clearly differentiated from eastern H. r. gutturalis and H. r. mandschurica, while north-eastern populations (named H. r. mandschurica) have darker, redder ventral plumage than H. r. rustica and H. r. gutturalis. However, we inferred that although there were phenotypic differences between H. r. mandschurica and H. r. gutturalis, they were not sufficiently distinct to assign them to separate subspecies based on the 75% rule for defining subspecies.
Protection as a Human Fundamental Need: Re-Conceiving Signs of Safety for Social Work in the Republic of Ireland
Authors: Flynn Susan 
Published: June 2020

AbstractLarge-scale reform of statutory child protective services in the Republic of Ireland is underway, prompted by adoption of the national strengths-based and safety-organised practice approach, known as ‘Signs of Safety’ (SoS). Despite the radical change it impels, critical commentary from the academy on the conventions of SoS remains conspicuous by its absence. One reading of the ecological systems approach is that to appreciate implications of SoS for children and families at risk, we must surpass a sequestered concern with child protection and welfare alone. To substantiate this, and embed a reconceived Signs of Safety, human scale development theory is critically deployed through an augmented, rather than exclusive focus, on the axis of protection needs within the typology of fundamental human needs. To aid this, critical application of theory is partially reworked and appropriated through a life course perspective, to better account for lifespan positioning. Overall, the sustaining proposition of the paper is that academic interrogation of SoS is both a practical and ethical imperative, and a necessary complement to large-scale organisational change underway.
Embeddedness dilemma and alternative commoditization of social economy in rural China: a case study
Authors: He Yufei , Chui Ernest Wing Tak 
Published: June 2020

AbstractThis article identifies different aspects of the embeddedness dilemma in a rural social economy project in South China. The term ‘alternative commodification’ is proposed to summarize the practitioners’ strategy. This strategy highlighted social embeddedness of economic development, but on the other hand involved the village deeper into the commodification process. Participants of the project only focused on newly emerged economic opportunities, with little concern of the embeddedness goal. Based on social transformation theory of Wright, the article also identifies two social reproduction mechanisms brought by marketization reform as structural barriers for realizing embeddedness goal: universal commodification and consumerism, both of which intensify villagers’ demand for cash income and ignorance of social dimensions of the project. Future research also needs to identify more barriers and methods to overcome obstacles in the process of developing social economy.
Distributed Motor Control of Limb Movements in Rat Motor and Somatosensory Cortex: The Sensorimotor Amalgam Revisited
Authors: Halley Andrew C , Baldwin Mary K L , Cooke Dylan F , Englund Mackenzie , Krubitzer Leah 
Published: June 2020

Abstract
Which areas of the neocortex are involved in the control of movement, and how is motor cortex organized across species? Recent studies using long-train intracortical microstimulation demonstrate that in addition to M1, movements can be elicited from somatosensory regions in multiple species. In the rat, M1 hindlimb and forelimb movement representations have long been thought to overlap with somatosensory representations of the hindlimb and forelimb in S1, forming a partial sensorimotor amalgam. Here we use long-train intracortical microstimulation to characterize the movements elicited across frontal and parietal cortex. We found that movements of the hindlimb, forelimb, and face can be elicited from both M1 and histologically defined S1 and that representations of limb movement types are different in these two areas. Stimulation of S1 generates retraction of the contralateral forelimb, while stimulation of M1 evokes forelimb elevation movements that are often bilateral, including a rostral region of digit grasping. Hindlimb movement representations include distinct regions of hip flexion and hindlimb retraction evoked from S1 and hip extension evoked from M1. Our data indicate that both S1 and M1 are involved in the generation of movement types exhibited during natural behavior. We draw on these results to reconsider how sensorimotor cortex evolved.
Why does classical reception need disability studies?
Authors: Silverblank Hannah , Ward Marchella 
Published: June 2020

AbstractMany of the ableist tropes around disability and disabled people in the modern world find their antecedents in ancient mythology and its reception, but the seemingly ‘traditional’ nature of these harmful tropes and reflexes of storytelling is not established by accident or in the absence of readers. We argue here that classical reception needs to look to disability studies for a methodology that will allow the field to begin to theorize the role of the reader in the perpetuation of the ideology of ableism and ideas of bodily normativity. The field of classical reception studies engages in the process of investigating how the ‘traditional’ comes to be accepted as pre-existing; as such, it is vital that classical reception look to disability studies for the tools with which to lay bare the ways in which the apparatus of ableism comes to seem traditional. This article sets out some strategies for bringing classical reception and disability studies together with the aim of developing a more critical philology, an ethically-invested method for doing classical reception, and the theoretical and practical tools to create a more inclusive field. In short, this article makes the case for ‘cripping’ classical reception studies.
The Cost of Human Capital Depreciation During Unemployment
Authors: Laureys Lien 
Published: June 2020

Abstract
This paper argues that human capital depreciation during unemployment generates an externality in job creation: firms ignore how their hiring decisions affect the skill composition of the future unemployment pool, and hence the output produced by new hires. As a consequence, job creation is too low from a social point of view. But the extent to which it is too low varies over the cycle. The reason is that the increase in the expected productivity of a new hire from next period’s unemployment pool caused by hiring an additional worker today, depends on the pool’s composition, which varies over the cycle.
Characterization of Roseibacterium persicicum sp. nov., and emended description of the genus Roseibacterium
Authors: Yoon Jaewoo 
Published: June 2020

ABSTRACT
A novel alphaproteobacterium, designated as KMU-115T, was isolated from seawater collected on the coast of Chuam Beach, Republic of Korea, and subjected to a polyphasic characterization. The cells were pale apricot-colored, strictly aerobic, Gram-staining-negative, rod-shaped, non-motile and chemoorganoheterotrophic. The novel isolate grew at NaCl concentrations of 0–7%, pH 6.0–9.5 and 10–45°C. A phylogenetic analysis based on the 16S rRNA gene sequence revealed that strain KMU-115T belongs to the family ‘Rhodobacteraceae’, and that it had the greatest sequence similarity (96.8%) with ‘Roseibacterium beibuensis’ JLT1202rT. The major respiratory quinone system of the novel isolate was ubiquinone-10 (Q-10) and the main (&gt;10%) cellular fatty acid was C18:1 ω7c. The assembled draft genome size of strain KMU-115T was 3.71 Mbp. The genomic DNA G + C content was 70.8 mol%. Strain KMU-115T had phosphatidylglycerol, four unidentified aminolipids, an unidentified aminophospholipid and seven unidentified lipids as polar lipids. From the distinct polyphasic taxonomic characteristics, the strain is considered to represent a novel species of the genus Roseibacterium for which the name Roseibacterium persicicum sp. nov. is proposed. The type strain of R. persicicum sp. nov. is KMU-115T (= KCCM 90339T = NBRC 114190T). An emended description of the genus Roseibacterium is also provided.
Adjudicating the troubles: violence, memory, and criminal justice at the end of the Wars of Religion
Authors: Hamilton Tom 
Published: June 2020

Abstract
This article provides a new perspective on the themes of violence, memory and criminal justice at the end of the Wars of Religion by focusing on a particularly well-documented criminal case tried by the Parlement de Paris. Previous studies of the end of the troubles have often focused on the politics and personality of Henri IV or studied the memory culture of elites. This article instead examines how the witnesses who confronted the royalist military captain Mathurin de La Cange made use of a broad social memory of the civil wars and shows how their use of the courts formed part of a larger pattern of post-war conflict resolution. This was a time when people in France endured decades of warfare and confessional division, but nevertheless emerged determined to put an end to the violence by committing to resolve their disputes through the law.
Coping Patterns Among Primary Informal Dementia Caregivers in Singapore and Its Impact on Caregivers—Implications of a Latent Class Analysis
Authors: Yuan Qi , Wang Peizhi , Tan Tee Hng , Devi Fiona , Poremski Daniel , Magadi Harish , Goveas Richard , Ng Li Ling , Chong Siow Ann , Subramaniam Mythily 
Published: June 2020

AbstractBackground and ObjectivesExisting studies typically explore the factor structure of coping strategies among dementia caregivers. However, this approach overlooks the fact that caregivers often use different coping strategies simultaneously. This study aims to explore the coping patterns of primary informal dementia caregivers in Singapore, examine their significant correlates, and investigate whether different patterns would affect the depressive symptoms of caregivers.Research Design and MethodsTwo hundred eighty-one primary informal caregivers of persons with dementia (PWD) were assessed. Coping strategies were measured by the Brief Coping Orientation to Problem Experienced inventory. A latent class analysis was performed to explore caregivers’ coping patterns, followed by logistic regressions to identify the significant correlates and the relationships between coping patterns and caregiver depression.ResultsThe latent class analysis suggested a three-class solution that was featured by the frequency and variety of coping strategies used by caregivers—high coping (36.3%), medium coping (37.7%), and low coping (26.0%). Factors influencing the coping patterns of our sample were mainly related to caregivers’ individual resources such as personal characteristics and caregiving stressors like PWD’s problematic behaviors and caregiving burden. Compared to caregivers in the low coping group, those in the medium coping group had significantly higher risks of potential depression.Discussion and ImplicationsThe current study confirmed that there are distinct coping patterns among primary informal dementia caregivers, and caregivers with the low coping pattern had fewer depressive symptoms. Future research is needed to explore if coping patterns from our sample are generalizable to dementia caregivers elsewhere.
PICALM rescues glutamatergic neurotransmission, behavioural function and survival in a Drosophila model of Aβ42 toxicity
Authors: Yu Yifan , Niccoli Teresa , Ren Ziyu , Woodling Nathaniel S , Aleyakpo Benjamin , Szabadkai Gyorgy , Partridge Linda 
Published: June 2020

Abstract
Alzheimer’s disease (AD) is the most common form of dementia and the most prevalent neurodegenerative disease. Genome-wide association studies have linked PICALM to AD risk. PICALM has been implicated in Aβ42 production and turnover, but whether it plays a direct role in modulating Aβ42 toxicity remains unclear. We found that increased expression of the Drosophila PICALM orthologue lap could rescue Aβ42 toxicity in an adult-onset model of AD, without affecting Aβ42 level. Imbalances in the glutamatergic system, leading to excessive, toxic stimulation, have been associated with AD. We found that Aβ42 caused the accumulation of presynaptic vesicular glutamate transporter (VGlut) and increased spontaneous glutamate release. Increased lap expression reversed these phenotypes back to control levels, suggesting that lap may modulate glutamatergic transmission. We also found that lap modulated the localization of amphiphysin (Amph), the homologue of another AD risk factor BIN1, and that Amph itself modulated postsynaptic glutamate receptor (GluRII) localization. We propose a model where PICALM modulates glutamatergic transmission, together with BIN1, to ameliorate synaptic dysfunction and disease progression.
C1orf194 deficiency leads to incomplete early embryonic lethality and dominant intermediate Charcot–Marie–Tooth disease in a knockout mouse model
Authors: Huang Cheng , Shen Zong Rui , Huang Jin , Sun Shun Chang , Ma Di , Li Mei Yi , Wang Zhi Kui , Zheng Ying Chun , Zheng Zhuo Jun , He Fei , Xu Xiaoyuan , Li Ziang , Zheng Bo Yang , Li Yue Mao , Xu Xiang Min , Xiong Fu 
Published: June 2020

Abstract
Charcot–Marie–Tooth (CMT) disease is the most common inherited peripheral neuropathy and shows clinical and genetic heterogeneity. Mutations in C1orf194 encoding a Ca2+ regulator in neurons and Schwann cells have been reported previously by us to cause CMT disease. In here, we further investigated the function and pathogenic mechanism of C1or194 by generating C1orf194 knockout (KO) mice. Homozygous mutants of C1orf194 mice exhibited incomplete embryonic lethality, characterized by differentiation abnormalities and stillbirth on embryonic days 7.5–15.5. Heterozygous and surviving homozygous C1orf194 KO mice developed motor and sensory defects at the age of 4 months. Electrophysiologic recordings showed decreased compound muscle action potential and motor nerve conduction velocity in the sciatic nerve of C1orf194-deficient mice as a pathologic feature of dominant intermediate-type CMT. Transmission electron microscopy analysis revealed demyelination and axonal atrophy in the sciatic nerve as well as swelling and loss of mitochondrial matrix and other abnormalities in axons and Schwann cells. A histopathologic examination showed a loss of motor neurons in the anterior horn of the spinal cord and muscle atrophy. Shorter internodal length between nodes of Ranvier and Schmidt–Lanterman incisures was detected in the sciatic nerve of affected animals. These results indicate that C1orf194 KO mice can serve as an animal model of CMT with a severe dominant intermediate CMT phenotype that can be used to investigate the molecular mechanisms of the disease and evaluate the efficacy of therapeutic strategies.
A systematic evaluation on reporting quality of modern studies on pulmonary heart valve implantation in large animals
Authors: Uiterwijk Marcelle , Vis Annemijn , de Brouwer Iris , van Urk Debora , Kluin Jolanda 
Published: June 2020

Abstract

OBJECTIVES
Before new heart valves can be implanted safely in humans, animal experiments have to be performed. These animal experiments have to be clearly designed, analysed and reported to assess the accuracy and importance of the findings. We aimed to provide an overview of the reporting and methodological quality of preclinical heart valve research.

METHODS
We conducted a systematic literature search on biological and mechanical pulmonary valve implantations in large animals. We used the Animals in Research: Reporting In Vivo Experiments (ARRIVE) guidelines to score the quality of reporting in each article. We compared the scores before and after the introduction of the ARRIVE guidelines (2010).

RESULTS
We screened 348 articles, of which 31 articles were included. The included articles reported a mean of 54.7% adequately scored ARRIVE items (95% confidence interval 52.2–57.3%). We did not identify a difference in reporting quality (54.7% vs 54.8%) between articles published before and after 2010. We found an unclear (lack of description) risk of selection bias, performance bias and detection bias.

CONCLUSIONS
The reporting quality of studies that implanted bioprosthetic or mechanical valves in the pulmonary position in the large animal model is not on the desired level. The introduction of the ARRIVE guidelines in 2010 did not improve the reporting quality in this field of research. Hereby, we want to emphasize the importance of clearly describing the methods and transparently reporting the results in animal experiments. This is of great importance for the safe translation of new heart valves to the clinic.

Clinical trial registration number
PROSPERO (CRD42019147895).
Monolingual Online Dictionaries for Learners of English and the Opportunities of the Electronic Medium: A Critical Survey
Authors: Heuberger Reinhard 
Published: June 2020

Abstract
Online dictionaries provide unique possibilities to both dictionary makers and users, in particular in the following areas (cf. Granger 2012: 4ff): Accessibility of data, multimedia functions, customization, hybridization, user-input and storage space. This article investigates the extent to which these opportunities have been exhausted in current online learner’s dictionaries. It demonstrates that the vast technological opportunities of the internet are only beginning to be fully exploited. While storage space, for example, is already being used effectively to provide additional example sentences and collocations, the dictionaries under investigation offer partly unsatisfactory functionality in terms of data accessibility and several other areas.