bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bridging the gap between student instruction and advanced research: Educational software tool for manufacturing learning
Authors: Urbikain Gorka , López de Lacalle Luis Norberto 
Published: July 2020

AbstractCurrently, there is a big gap between industry and the instructions provided by engineers at the University. Manufacturing companies need engineers with specific profiles and skills in machining. Teachers, who face both worlds, must play an active role in shortening the transition times of students. Recently, barrel‐end mills have been the focus of attention of toolmakers and manufacturers due to their excellent production times and surface accuracies. They are outstanding competitors to more traditional ball‐end mills in some applications. This study raises the challenge of translating the developed work for this kind of tool from the research domain into the classroom at the University. For this, a software tool proBARR© was developed and used for learning of the subject of manufacturing. This educational software is capable of predicting cutting forces and surface topography in milling with barrel‐end mills and was successfully introduced as part of the students' learning process. A software tool was created for the analysis and prediction of cutting forces and surface quality in milling processes with barrel‐end mills. This specific problem was addressed from past experience in research projects but was then adapted for academic use. The teachers believe that, if suitably presented to students, the tool provides an excellent opportunity to approach real problems in industry, thus boosting instructions for future engineers. In this way, a pragmatic methodology to computational thinking is presented that transforms traditional difficulties associated with process modeling into more comprehensive tasks, more oriented toward solving specific problems.
Using process simulators in Chemical Engineering education: Is it possible to minimize the “black box” effect?
Authors: Roman Claudia , Delgado Miguel A. , García‐Morales Moisés 
Published: July 2020

AbstractSimulators are instrumental to engineers and scientists, in general, and to chemical engineers,more specifically, which enable the optimization and analysis of alternative solutions in a time‐efficient and cost‐effective way. Thus, their integration into Chemical Engineering studies has gained traction over the years in supporting traditional lectures or as the sole tool for knowledge transmission. However, despite their proven benefits in Higher Education, limitations exist, as the application of the tool may result in deficient learning. In fact, the algorithms and design equations that are used to transform inputs into results are not identifiable by the students, thereby instilling a “superficial understanding” of the problem. Thus, the objective of this paper is to provide some guidelines through three simple case studies, which may help minimize the so‐called “black box” effect. Two different state‐of‐the‐art computational tools were used in parallel. Aspen One simulations provided the reference point, which was used by the students to verify the process models built by them with Mathcad Prime. A survey taken by the students then allowed conclusions to be made, which concurred that the experience had been very successful.
Safety‐net hospitals versus non‐safety centers and clinical outcomes after trans‐catheter aortic valve replacement
Authors: Sheikh Muhammad Adil , Deo Salil V. , Riaz Haris , Raza Sajjad , Altarabsheh Salah E. , Wilson Brigid , Elgudin Yakov , Cmolik Brian , Pelletier Marc , Markowitz Alan H. 
Published: July 2020

AbstractObjectiveTo compare post‐procedural outcomes of trans‐catheter valve replacement (TAVR) among safety‐net (SNH) and non‐safety net hospitals (non‐SNH).BackgroundSNH treat a large population of un‐insured and low income patients; prior studies report worse outcome at these centers. Results of TAVR at these centers is limited.MethodsAdults undergoing TAVR at hospitals in the US participating in the National In‐patient sample (NIS) database from January 2014 to December 2015 were included. A 1:1 propensity‐matched cohort of patients operated at SNH and non‐SNH institutions was analyzed, on the basis of 16 demographic and clinical co‐variates. Main outcome was all‐cause post‐procedural mortality. Secondary outcomes included stroke, acute kidney injury and length of post‐operative stay.ResultsBetween 2014 and 2015, 41,410 patients (mean age 80 ± 0.11 years, 46% female) underwent TAVR at 731 centers; 6,996 (16.80%) procedures were performed at SNH comprising 135/731 (18.4%) of all centers performing TAVR. SNH patients were more likely to be female (49% vs. 46%, p < .001); admitted emergently (31% vs. 21%; p < .001; at the lowest quartile for household income (25% % vs. 20%; p < .001) and from minorities (Blacks 5.9% vs. 3.9%; Hispanic 7.2% vs. 3.2%).Adjusted logistic regression was performed on 6,995 propensity‐matched patient pairs. Post‐procedural mortality [OR 0.99(0.98–1.007); p = .43], stroke [OR 1.009(0.99–1.02); p = .08], acute kidney injury [OR 0.99(0.96–1.01); p = .5] and overall length of stay (6.9 ± 0.1 vs. 7.1 ± 0.2 days; p = .57) were comparable in both cohorts.ConclusionPost‐procedural outcomes after TAVR at SNH are comparable to national outcomes and wider adoption of TAVR at SNH may not adversely influence outcomes.
Impact of a contrast media volume control device on acute kidney injury rate in patients with acute coronary syndrome
Authors: Briguori Carlo , Golino Marco , Porchetta Nicola , Scarpelli Mario , De Micco Francesca , Rubino Carmine , Focaccio Amelia , Signoriello Giuseppe 
Published: July 2020

AbstractBACKGROUNDThe DyeVert™ system (Osprey Medical Inc., Minnesota, MN) may reduce contrast media (CM) volume during coronary procedures while maintaining fluoroscopic image quality. Here, we assessed whether the use of the DyeVert system reduces acute kidney injury (AKI) rate in patients with acute coronary syndrome (ACS) undergoing invasive coronary procedures.METHODSACS patients scheduled for coronary procedure from January 2017 to December 2019 were included. Two groups were identified: (a) Control group (n = 339), including patients in which a conventional manual injection syringe was used; and (b) DyeVert group (n = 112), in which CM injection was handled by the DyeVert™ system. A propensity score matching was performed to reduce the effect of treatment selection bias and potential confounders. In all cases, a low‐osmolar, nonionic CM was administered. The primary objective was the rate of AKI, defined as a serum creatinine increase ≥0.3 mg/dl within 72 hr after CM exposure.RESULTSCM volume was higher in the Control group than in the DyeVert group (130 [120–188] ml vs. 99 [69–136] ml; p <.001). In the DyeVert group the mean percent CM volume saved was 38 ± 13%. AKI occurred in 7/90 patients (8%) in the DyeVert group and in 17/90 (19%) patients in the Control group (odds ratio = 0.37; 95% confidence interval 0.14–0.95; p =.047).CONCLUSIONSThis preliminary result suggests that CM volume reduction obtained by the DyeVert™ system is an effective strategy to prevent AKI in ACS patients undergoing invasive procedure.
The reversed bell‐bottom technique (ReBel‐B) for the endovascular treatment of iliac artery aneurysms
Authors: Mazzaccaro Daniela , Righini Paolo , Zuccon Gianmarco , Modafferi Alfredo , Malacrida Giovanni , Nano Giovanni 
Published: July 2020

AbstractObjectiveTo describe the results of the reversed bell‐bottom (ReBel‐B) technique for the endovascular treatment of iliac aneurysms (IA) involving the origin of hypogastric artery (HA).MethodsThe ReBel‐B technique is a strategy for the occlusion of HA in selected patients presenting with IA, in whom the HA cannot be spared or safely occluded with coils or vascular plugs. When employing this technique, an iliac flared (“bell‐bottom”) extension is deployed in a reverse fashion, through a contralateral crossover femoral access that allows the occlusion of the HA at its origin, by exploiting the flared “bell” part of the reversed endograft. A second limb is then deployed to complete the implant, from the common iliac to the external iliac artery, inside the previous graft.Data of all consecutive patients treated with this technique in our experience were then retrospectively reviewed, and outcomes analyzed.ResultsThe ReBel‐B technique was employed in total of six patients who came in an emergent setting for the rupture of a common IA, from January 2014 to December 2018. Endovascular exclusion was performed using a ReBel‐B graft plus iliac leg in five out of six cases. In the remaining case, a bifurcated aortic endograft was used to complete the aneurysm exclusion. Technical success was 100%. No complications occurred.ConclusionsIn selected cases, the ReBel‐B technique can be used for the complete exclusion of IA preventing type II endoleak from the HA, when the embolization with coils or plug or the preservation of the HA is anatomically unfeasible.
Malnutrition and chyle leakage: A life‐threatening duo in heart transplantation post‐Fontan procedure
Authors: Lezo Antonella , Aidala Enrico , Deorsola Luca , Cascarano Maria Teresa , Rizzo Alberta , Iannandrea Stefania , Peruzzi Licia , Runfola Federica , Pace Napoleone Carlo 
Published: July 2020

AbstractProtein‐losing enteropathy and chyle leakage may lead to severe malnutrition in heart transplantation for failing Fontan. Nutritional management may be challenging from defining nutrient needs to diagnosis of malnutrition enteropathy, and expertise is necessary. Body composition and hematological nutritional indices may help define malnutrition severity and guide nutritional strategy.
Neonatal tetanus in St. Mary’s Hospital Lacor: A case report
Authors: Okidi Ronald , Sambo Vanusa Da Consolação , Eyul Jacob 
Published: July 2020

AbstractUmbilical stump sepsis in a nonpassively immunized neonate poses a high risk to neonatal tetanus. Management of neonatal tetanus is still a great challenge in resource‐limited settings where some health facilities lack tetanus toxoid containing vaccines, ventilator support, and inaccessibility of tetanus immunoglobulin.
Impacts of lower‐leaf removal timing, number, and nitrogen application to flue‐cured tobacco
Authors: Finch Camden E. , Vann Matthew C. , Wells Randy , Fisher Loren R. , Brown A. Blake 
Published: July 2020

AbstractThe removal and exclusion of lower‐stalk tobacco (Nicotiana tobacum L.) from harvest continues to be encouraged by industry. Very little information addresses the timing aspect of leaf removal, specifically when it occurs near floral initiation. Research was conducted in 2016 and 2017 to evaluate each possible treatment combination of two lower‐leaf removal programs (0 and 8 leaves/plant), three removal timings (2 wk before topping, at topping, and 2 wk after topping), and two N application rates (0 and 10 lb/ac). Soil plant analysis development (SPAD) measurements consistently revealed a lighter leaf color in treatments consisting of leaf removal 2 wk before topping, regardless of N application rate. Foliar cured leaf samples from upper‐stalk positions also contained less total N when eight leaves (2.25%) were removed relative to zero leaves (2.32%). These results indicate that subsequent N fertilizer application did not supply N as efficiently as remobilization from lower, older leaves. In the 8‐leaf removal program, both cured leaf yield and value declined by 27% relative to the 0‐leaf program. Despite significant losses in yield and value, the 8‐leaf program completely eliminated lug grades of tobacco. Leaf removal timing and N application rate did not affect yield, quality, value, or grade distribution. Our results suggest that there is no agronomic or cost to removing lower leaves 2 wk before or after topping; however, commercial farmers may find this information to be of use from a time management perspective, should they decide to implement this practice.
Rational Design of a Uranyl Metal–Organic Framework for the Capture and Colorimetric Detection of Organic Dyes
Authors: Surbella Robert G. , Carter Korey P. , Lohrey Trevor D. , Reilly Dallas , Kalaj Mark , McNamara Bruce K. , Schwantes Jon , Abergel Rebecca J. 
Published: July 2020

AbstractA new uranyl containing metal–organic framework, RPL‐1: [(UO2)2(C28H18O8)] . H2O (RPL for Radiochemical Processing Laboratory), was prepared, structurally characterized, and the solid‐state photoluminescence properties explored. Single crystal X‐ray diffraction data reveals the structure of RPL‐1 consists of two crystallographically unique three dimensional, interpenetrating nets with a 4,3‐connected tbo topology. Each net contains large pores with an average width of 22.8 Å and is formed from monomeric, hexagonal bipyramidal uranyl nodes that are linked via 1,2,4,5‐tetrakis(4‐carboxyphenyl)benzene (TCPB) ligands. The thermal and photophysical properties of RPL‐1 were investigated using thermogravimetric analysis and absorbance, fluorescence, and lifetime spectroscopies. The material displays excellent thermal stability and temperature dependent uranyl and TCPB luminescence. The framework is stable in aqueous media and due to the large void space (constituting 76 % of the unit cell by volume) can sequester organic dyes, the uptake of which induces a visible change to the color of the material.
Diazaboryl‐naphthyl‐ketone: A New Scaffold with Bright Fluorescence, Aggregation‐Induced Emission, and Application in the Quantitation of Trace Boronic Acids in Drug Intermediates
Authors: Hackney Hannah E. , Paladino Marco , Fu Hao , Hall Dennis G. 
Published: July 2020

AbstractThis study describes the synthesis, structure, and photophysical properties of a new luminescent polyaromatic boronic acid scaffold, diazaboryl‐naphthyl‐ketones (DNKs). These stable compounds display extremely bright fluorescence, aggregation‐induced emission, positive solvatochromism, and solid‐state fluorescence. DFT calculations and X‐ray crystallographic study revealed notable electronic and structural differences between these compounds and the parent diaminonaphthalene (DAN) adducts. Acylation of the DAN system causes a localization of both HOMO and LUMO onto the DNK unit, which validates the negligible influence of the B‐aryl substituent. The LUMO energy is lowered, and its shape significantly altered. Photophysical data in solution and the solid state revealed blue‐shifted, narrowed, and intense emissions for DNKs (up to 89 % quantum yield). The potential utility of the fluorogenic DNK system was demonstrated with a proof‐of‐concept for the determination of trace boronic acid contaminants in solid samples, down to one‐ppm level, using HPLC with fluorescence detection. This method could be useful in pharmaceutical development for the quantitation of difficult‐to‐detect and potentially mutagenic residual boronic acid from late cross‐coupling reactions in drug syntheses.
Synthesis and Characterization of Fluorodinitrobenzenes with Tunable Melting Point: Potential Low Sensitive Energetic Plasticizer and Melt‐Cast Carrier†
Authors: Li Yunlu , Chen Peng , Liu Yan , Yin Ping , He Chunlin , Pang Siping 
Published: July 2020

Summary of main observation and conclusionIn order to explore the effects of fluoro substituents on the energy and safety of energetic compounds, a series of fluorodinitrobenzenes including 1,3‐difluoro‐2,4‐dinitrobenzene (1), 1,5‐difluoro‐2,4‐dinitrobenzene (2), 1,2,3‐trifluoro‐4,6‐dinitrobenzne (3) and 1,3,5‐trifluoro‐2,4‐dinitrobenzene (4) were prepared. All the compounds were fully characterized. The structures of 2 and 3 were further confirmed by single crystal X‐ray diffraction analysis. The results show that these compounds exhibit comparable detonation properties (D = 6703‐6978 m·s–1, and p = 21.3—23.7 GPa) to those of 2,4,6‐trinitrotoluene (TNT) due to the significantly increased density of fluorine introduced. Low sensitivity (IS > 40 J, and FS > 360 N) of these compounds along with different melting points make them potential candidates for different allocation. Among them, 1 and 4 with the melting point of 42.5 °C and 55.2 °C, respectively, show promise for application in the field of energetic plasticizer. Compounds 2 and 3 are potential low sensitive melt‐cast carrier due to their similar melting point and superior detonation performance to that of TNT.
Optimization of 4‐Substituted Benzenesulfonamide Scaffold To Reverse Acinetobacter baumannii Serum‐Adaptive Efflux Associated Antibiotic Tolerance
Authors: Chojnacki Michaelle , Cao Xufeng , Young Mikaeel , Fritz Rebecca N. , Dunman Paul M. , Flaherty Daniel P. 
Published: July 2020

AbstractAcinetobacter baumannii is a nosocomial pathogen of urgent concern for public health due to rising rates of multidrug and pandrug resistance. In the context of environmental cues such as growth in human serum, A. baumannii is known to display adaptive efflux, in which a multitude of efflux‐associated genes are upregulated, resulting in efflux‐mediated drug tolerance in strains that are otherwise susceptible to antibiotic therapy. Previously, we identified a sulfonamide‐containing scaffold molecule (ABEPI1) that reversed serum‐associated antibiotic tolerance in A. baumannii. Herein, we present structure‐activity relationship studies on 29 newly synthesized analogues. These molecules were characterized for their ability to potentiate multiple antibiotics in serum, reduce serum‐associated ethidium bromide efflux and depolarize bacterial cell membranes. In addition, they were assessed for toxicity to mammalian cells. Collectively, these molecules may represent promising potential adjuvants for use in combination with new and existing antibiotics to treat A. baumannii bacterial infections.
An efficient certificateless public auditing scheme in cloud storage
Authors: Gao Gaimei , Fei Hongxia , Qin Zefeng 
Published: July 2020

AbstractCloud storage is a mode of online storage in which data are stored on multiple virtual servers usually hosted by third parties. Cloud service providers manage and operate data storage as services. The major concern in cloud storage is the integrity of outsourced data. Many public auditing schemes which authorize the third party auditor (TPA) to check the integrity of outsourced data have been proposed. However, most of them are based on traditional public key cryptosystems. This paper proposes an efficient certificateless public auditing Scheme (CL‐PAS) in cloud storage. In the process of challenge and auditing, CL‐PAS ensures that malicious cloud servers cannot forge auditing evidences to deceive TPA to pass the verification, and prevents curious TPA from recovering original data from auditing evidences. So it strengthens privacy preserving. Security analysis shows that CL‐PAS scheme meets the predetermined security requirements. The simulation and performance analysis results show that, compared with similar schemes, CL‐PAS scheme has the higher efficiency.
Doubled haploids in maize: Development, deployment, and challenges
Authors: Maqbool Muhammad Amir , Beshir AbduRahman , Khokhar Ehtisham Shakeel 
Published: July 2020

AbstractHaploids are naturally produced in maize (Zea mays L.) at different rates and can also be induced through different methods. Haploids are used to develop doubled haploids (DHs), which have many potential uses. The development of DH lines in maize involves haploid induction, haploid identification, chromosome doubling, and field sowing for self‐pollination of D0 plants. Different potential methods are used for haploid induction, in‐vivo maternal haploid induction being the most prevalent. Haploid induction is highly reliant on the unambiguous identification of haploids among a mixture of different ploidies. Haploid identification is facilitated by visual morphological markers, chromosome counting, flow cytometry, molecular markers, and many other approaches. Chromosome doubling may be achieved by spontaneous doubling or by induction with different antimicrotubular treatments. Among the potential uses of DH lines are the development of inbred lines, genomic selection (GS), quantitative trait loci (QTL) mapping, and unlocking new genetic variations. Although DH technology can potentially accelerate maize breeding, it still faces challenges at each step of DH line development. This article aims to highlight the importance, procedural steps, potential opportunities, and key challenges in DH line development in maize.
Performance of multiple turfgrass species during prolonged heat stress and recovery in a controlled environment
Authors: Breuillin‐Sessoms Florence , Watkins Eric 
Published: July 2020

AbstractIncreasing temperatures associated with climate change will be the next challenge for crop improvement, especially for turfgrass species that are often grown in urban green spaces. Previous research on turfgrass heat stress tolerance has been limited to a small number of species and cultivars with different heat stress conditions between studies; therefore, we assessed heat stress tolerance of 34 turfgrasses representing 14 species. Four replicates of each entry were established for at least 12 wk and then subjected to 49 d of heat stress (35/25 °C day/night) followed by a 4 wk recovery period (25/15 °C day/night). Turfgrass entries were assessed using the normalized difference vegetative index, the percentage of green obtained with digital image analysis, and membrane stability estimated by electrolyte leakage. Buffalograss [Bouteloua dactyloides (Nutt.) J.T. Columbus], Kentucky bluegrass (Poa pratensis L.), tall fescue [Schedonorus arundinaceus (Schreb.) Dumort], and slender creeping red fescue (Festuca rubra ssp. littoralis) were more tolerant of heat stress than the other species. The Canada bluegrass (Poa compressa L.), blue grama [Bouteloua gracilis (Willd. ex Kunth.) Lag. ex Griffiths], and smooth brome (Bromus inermis Leyss.) cultivars were all tolerant of heat stress; however, only one cultivar for these three species was tested, making species‐wide generalizations difficult. In some cases, the cultivars and/or selections within a given species differed in heat stress response. Almost all entries were able to recover from the heat stress by the end of the recovery period. Altogether, we were able to identify turfgrasses that should perform adequately in high‐temperature urban environments.
Cocultivating rye with berseem clover affects benzoxazinoid production and expression of related genes
Authors: Rakoczy‐Trojanowska Monika , Święcicka Magdalena , Bakera Beata , Kowalczyk Mariusz , Stochmal Anna , Bolibok Leszek 
Published: July 2020

AbstractBenzoxazinoids (BXs) are secondary metabolites synthesized mainly by gramineous plants, including rye (Secale cerealeL.), that play an important role in stress resistance and allelopathy. In the present work, the influence of cocultivation of rye with berseem clover (Trifolium alexandrinumL.) on the expression of BX synthesis‐regulating genes (ScBx1–ScBx5,ScIgl, andScGT) and the content of six BXs (HBOA, DIBOA, GDIBOA, DIMBOA, GDIMBOA, and MBOA) in roots and the aerial portion of three rye inbred lines (ILs) (L318, D33, and D39) was investigated. Cocultivation of rye with berseem clover influenced its gene expression levels and BX contents. The response was strongly affected by rye genotype, plant part, time point, gene, and metabolite. The most frequently observed changes of gene expression concerned IL D33, aerial plant parts, the second time point (4 wk after germination), andScBx3. For BX synthesis, the most frequently observed changes for IL D33 were in roots, the third time point (6 wk after germination), GDIBOA, and DIBOA. In 18.3% of cases, gene expression was correlated with BX synthesis. The coregulation of gene expression and BX synthesis in roots and aerial parts of rye plants affected by clover was observed relatively rarely. Cocultivation of rye with clover led, after 6 wk, to BX increases in roots of all tested ILs. Despite the lack of clearly universal response, the cocultivation of rye with clover may strengthen rye defense capability, at least against soil pathogens.