bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluations of knowledge, skills and practices of insulin storage and injection handling techniques of patients in Ethiopian primary hospitals
Authors: Netere Adeladlew Kassie , Ashete Eyayaw , Gebreyohannes Eyob Alemayehu , Belachew Sewunet Admasu 
Published: May 2020

Abstract
Background: Insulin is an effective drug for blood sugar controls. Nonetheless, it is very sensitive and destroyed with many external factors if not properly handled. Diabetic patients could be benefited if adhered and properly implemented insulin delivery recommendations. Lack of knowledge, skill, and irrational practices on appropriate insulin delivery techniques can result in therapeutic failure and increases costs of therapy. The primary aim of this study was to evaluate the knowledge, skills and practices of insulin storage and injection technique of patients. Methods: Interview based cross-sectional study was conducted in conveniently selected participants in Northwest Ethiopian primary hospitals from March 1, 2019 to May30, 2019. Knowledge levels were assessed with dichotomous outcomes and practice was measured by administering a 4-point Likert scale structured questionnaire through face-to-face interviews. Finally, a five-point item observational (demonstration) techniques checklist assessed patients’ skills. Results: Of the total 166 participants, 54.8% were males and the mean age was 38.46±13.8 years. The overall patients’ median knowledge and practice levels on insulin storage and handling techniques were moderately adequate (64.3%) and fair (55.4%) respectively. In patients’ skill assessments, 94.6% showed injection sites, 70% indicated injection site rotations, and 60.75% practiced injection sites rotations. Education X2(3) =18.89, p<0.001; years of insulin therapy X2(3) =11.71, p=0.008; and years of disease X2(3) =10.67, p=0.014 had a significant effect on patients’ knowledge level. Education X2(3) =25.86, p<0.001; occupation X2(4) =23.24, p<0.001; and years of disease X2(3) =15.85, p=0.001; years of disease X2(3) =8.55, p=0.036 and patients knowledge levels X2(2) =19.26, p<0.001 were found to have a significant effect on the patients’ practice level. A Mann-Whitney U test also disclosed that residency; ways to get insulin and mocked injection technique during first training had significant effects on patients’ knowledge levels. Conclusion: The current study revealed that patients’ had a moderately adequate knowledge and fair practices levels on insulin storage and handling techniques. In addition, patients demonstrated poorly the administration skills, which were critical steps. The engagements of healthcare professionals and stakeholders in developments of instructions and guidelines are as important as educating and changing the poor knowledge and administration techniques of patients.
‘She must cover up whilst the baby is feeding’: Experiences and attitudes about breastfeeding among female and male informal workers in India and South Africa.
Authors: Horwood Christiane , Surie Aditi , Haskins Lyn , Luthuli Silondile , Hinton Rachael , Chowdhury Antara , Rollins Nigel 
Published: May 2020

Abstract
Background: Worldwide, over 740 million women make their living in the informal economy and do not benefit from formal employment benefits, such as maternity leave, that can improve infant feeding practices. Returning to work is one of the biggest challenges women face to maintaining breastfeeding. This study aimed to explore interactions between informal work and breastfeeding practices. Methods: The study used a qualitative research design. Purposive and snowball sampling was employed. Focus group discussions (FGDs) were conducted among men and women working in different types of informal jobs, in India and South Africa. Data was analysed using a thematic approach and the framework method. Results: Between March and July 2017, 14 FGDs were conducted in South Africa and nine in India. Most women were knowledgeable about the benefits of breastfeeding and reported initiating breastfeeding. However, pressures of family responsibilities and household financial obligations often forced mothers to return to work soon after childbirth. Upon return to work many mothers changed their infant feeding practices, adding breastmilk substitutes like formula milk, buffalo milk, and non-nutritive fluids like Rooibos tea. Some mothers expressed breastmilk to feed the infant while working but many mothers raised concerns about breastmilk becoming ‘spoilt’. Breastfeeding in the workplace was challenging as the work environment was described as unsafe and unhygienic for breastfeeding and childcare. Mothers also described being unable to complete their work tasks while caring for an infant. In contrast, the flexibility of informal work allowed some mothers to successfully balance competing priorities of child care and work. Sociocultural challenges influenced breastfeeding practices. For example, men in both countries expressed mixed views about breastfeeding. Breastfeeding was perceived as good for both mother and child, however it was culturally unacceptable for women to breastfeed in public. This affected the ability of working mothers to breastfeed outside the home and contributed to a lack of respect for women who chose to breastfeed in the workplace. Conclusion: Mothers working in the informal sector face multiple challenges to maintaining breastfeeding. Interventions are required to support optimal feeding and child care if global nutrition and development goals are to be met.
Prevalence of reduced visual acuity among school-aged children and adolescents in 6 districts of Changsha city: a population-based survey
Authors: Liao Menglian , cai zehuai , Khan Muhammad Ahmad , Miao Wenjie , Lin Ding , Tang Qiongyan 
Published: May 2020

Abstract
Background: To calculate and evaluate the prevalence of reduced uncorrected distant visual acuity (UCDVA) in primary and secondary school students in 6 districts of Changsha, Hunan, China. Methods: A population-based retrospective study was conducted in 239 schools in 6 districts of Changsha. After routine eye examination to rule out diseases that can affect refraction, 250,980 eligible students from elementary, middle and high schools were enrolled in the survey. Then the uncorrected distant and near visual acuity of each eye were measured. Categories of schools, districts, grades, eye exercises and sports time were also documented and analyzed. Results: The overall prevalence of reduced UCDVA was 51.8% (95% confidence interval [CI]: 51.6%-52.0%) in 6 districts of Changsha. Results of individual districts were as follows: Furong district 59.9%(95% CI: 57.9%-61.8%), Tianxin district 62.3%(95% CI: 60.5%-64.0%), Wangcheng district 47.8%(95% CI: 46.8%-48.8%), Kaifu district 58.5%(95% CI: 58.0%-58.9%), Yuhua district 47.0%(95% CI: 46.7%-47.4%) and Yuelu district 52.6%(95% CI: 52.3%-52.9%). The proportion of normal VA is seen to decrease from primary grade 3. The proportion of mildly reduced UCDVA is higher in primary grade 1 and 2. The proportion of moderately reduced UCDVA remains similar during 12 grades. The proportion of severely reduced UCDVA increases with grades. Multivariate analysis shows that the prevalence of reduced UCDVA is higher in key schools (odds ratio [OR]= 1.47, 95% CI 1.44-1.50) than non-key schools. Conclusions: According to the existing data analysis results, the prevalence of reduced UCDVA among primary and secondary school students in Changsha is very high. Some effective measures need to be taken to prevent it.
Awareness, treatment, and control of hypertension and related factors in adult Iranian Population
Authors: Mirzaei Mohsen , Mirzaei Masoud , Bagheri-Fahraji Behnam , Dehghani Ali 
Published: May 2020

Abstract
Background: Hypertension, known as the silent killer, is a major risk factor for cardiovascular disease. Awareness and treatment hypertension is not appropriate in the world, and this has led to an increase in mortality and morbidity caused by uncontrolled hypertension.This study aims to estimate awareness, treated, and controlled hypertensive and relevant predictors in an adult Iranian population.Methods: This cross-sectional study was conducted on 10000 adults aged 20-69 years in Yazd, Iran. They were selected through multi-stage random cluster sampling in 2015-2016.Blood pressure was measured three-time with standard protocol by trained health workers. Those with a positive history of hypertension and using anti-hypertensive drugs, prescribed by a physician, were considered hypertensive. Hypertension was defined as systolic blood pressure ≥140 mmHg and/or diastolic BP of ≥90 mmHg. Uncontrolled hypertension was defined in accordance with recommended treatment targets by the Joint National Committee (JNC7). Logistic regression was used to assess the predictors of hypertension awareness, treatment and control.Results: The prevalence of hypertension was 37.3%, and the prevalence of pre-hypertension was 46.4%. 49.7% of People with hypertension were aware of their disease, and 71.5% of them were using antihypertensive drugs prescribed by physicians. Blood pressure was controlled in 38.9% of the treated patients. In the adjusted model, older age, female sex, and history of diabetes mellitus were positively associated with higher awareness. High physical activity, tobacco smoking, and diabetes are the only predictors of treated high blood pressure. Younger age, female sex, and higher education were determinants of controlled hypertension. Having health insurance was significantly correlated with awareness and control of hypertension.Conclusion: Hypertension is a public health problem in this population, which is not well controlled. Half of the patients were unaware. Intervention for increased screening coverage is needed. It should plan to raise public awareness about hypertension and improve hypertension control under supervision of physicians. Implement a family physician program is recommended in the health system.
Sympathetic Ophthalmia Two Weeks After 23-Gauge Vitrectomy
Authors: Khatib Bahaeddin El , Patel Menka S. , Hacopian Alexander , Dalal Monica , Sen H. Nida , Patronas Marena 
Published: May 2020

Abstract
Sympathetic Ophthalmia (SO) is a rare disease that presents as a bilateral, diffuse, granulomatous panuveitis. Sympathetic Ophthalmia is a clinical diagnosis with history of penetrating ocular injury in the inciting eye and presence of panuveitis in the sympathizing eye. Though early enucleation is believed to minimize the risk, there have been reports of SO even after enucleation of inciting eyes. The possible association between vitrectomy and SO has been initially proposed by Gass [9] and later studied extensively in a large cohort in the UK with an estimated SO risk of 1 in 799 vitrectomies [11]. There have been several case series and reports of SO following vitrectomy, however only three documented cases of SO following vitrectomy without use of silicone oil. These cases demonstrated an onset of SO ranging between 4 weeks to 2 months. We present a patient with SO in the sympathizing eye presenting 16 days after an uncomplicated 23-gauge (23G) sutureless pars plana vitrectomy (PPV) without the use of silicone oil.
HIV positive status disclosure to a sexual partner: the influence of marital status and partner communication
Authors: ADENIYI OLADELE VINCENT , Nwogwugwu Charlotte , Ajayi Anthony Idowu , Lambert John 
Published: May 2020

Abstract
Background Disclosure of HIV serostatus to sexual partner does not only facilitate partner's support and testing, but it also correlates with better treatment outcomes. We drew from a cross-sectional survey data conducted among postpartum women with HIV to examine the rate of serostatus disclosure to sexual partners, the influence of relationship status, and knowing one's partner's status on disclosure and reasons for non-disclosure.Methods We conducted telephonic interviews with a final sample of 485 postpartum women with HIV drawn from the East London Prospective Cohort study database between January and May 2018. Disclosure of HIV status to partner was based on self-reporting. We fitted adjusted and unadjusted logistic regression models and also conducted descriptive statistical analyses.Results Overall, 82.5% of the respondents had disclosed their status to their partners. After adjusting for important covariates (age, education level, employment status, number of years since HIV diagnosis, alcohol use and smoking behaviour), being married [adjusted odd ratio (AOR): 2.66; 95% confidence interval (CI):1.17–6.05] and knowing one's partner's status [AOR: 46.91; 95% CI:19.50-112.81] were significantly associated with a higher odds of having disclosed HIV status to sexual partners. Fear of rejection, stigma or being judged, new or casual relationships, and having a violent partner were the main reasons for not disclosing HIV status to sexual partners.Conclusion We found a relatively high rate of HIV status disclosure in the cohort. Being married and having open communication with a partner about HIV status are important factors facilitating disclosure to sexual partners.
The Association of Hair Coloring During Pregnancy with Pregnancy and Neonate Outcomes: A Cross-Sectional Study
Authors: Shishavan Maryamalsadat Kazemi , Sayyah-Melli Manizheh , Rashid Mohammad Reza , Gharabaghi Parvin Mostafa , Ghojazadeh Morteza , Rahmani Vahideh , Tahmasebi Zohreh 
Published: May 2020

Abstract
Background: Hair colorant use has spread globally and rapidly in recent years. Concerns have arisen about the safety of hair dyes usage during pregnancy. The primary goal of this study was to examine the association between hair coloring during pregnancy, intrapartum, and neonatal outcomes.Methods: This explorative cross-sectional study was carried out at Talegani Teaching Hospital of Tabriz University of Medical Sciences from Jan 2017 to Dec 2019. Three trained midwives inquired mothers about the hair coloring history on the admission to the labor room and recorded intrapartum, and neonatal outcomes. Chi-Square test of independence with post hoc tests and Logistic regression analysis were used for data analysis. Odds Ratios with a 95% confidence interval and contributing effect sizes were reported. The significance level was set at α ≤ 0.05Results: We studied 2040 women aged 14 to 48 years. Most of the participants (75.24%) dyed their hair during pregnancy, and the majority (62.67%) colored their hair in the third trimester. There was no statistically significant association between hair coloring and neonate 1-minute (p=0.23) and 5-minute Apgar score (p=0.99). The logistic regression model did not confirm a rise in overall neonatal complications (NC) associated with hair coloring at any time during the pregnancy (OR:0.027 p<0.001). Higher rates of Low birth weight (LBW) were seen among those dyed their hair in the preconception period and third trimester compared to the woman who colored their hair in the first and second trimester (p<0.001).Conclusions: We observed associations between hair coloring and LBW, but there were no increased odds for NC. The evidence for recommending hair dye safety during pregnancy is still limited. Perinatal health professionals should advise their patients on possible adverse outcomes and inform them about the uncertainties about hair dyes.
Application of double needle-double layer continuous manual suture to complete digestive tract reconstruction in totally laparoscopic distal gastrectomy
Authors: Zhang Xinsheng , zhang weibin , yuan menglang , shi xiaomeng , CHEN HONGYI , feng zhen , chen zihao , liu dunbo , yan enjun , ren shuangyi 
Published: May 2020

Abstract
Background

Retrospectively register the clinical data of distal gastric cancer patients who received surgical treatment, discuss the safety and feasibility of double needle-double layer continuous manual suture to complete digestive tract reconstruction in totally laparoscopic distal gastrectomy.
Methods

Review the clinical data of 41 patients with distal gastric cancer from the gastroenterology department of the Second Affiliated Hospital of Dalian Medical University, from September 2018 to August 2019, were accepted the totally laparoscopic distal gastrectomy. During the operation, the method of double needle-double layer continuous manual suture was used for Billroth I type anastomosis to complete digestive tract reconstruction. The peri-operative clinical information and postoperative follow-up information were collected for analysis, and the clinical application value was evaluated.
Results

General Information: Male (n = 27),Female(n = 14)༌Age(65.02 ± 9.94)years, BMI(23.52 ± 2.56)kg/m2; Tumor location: Antrum(32,78.0%), Angle (6,14.6%), Body (3,7.3%); Clinical stage: I (27,65.9%), II (7,17.1%), III (7,17.1%); Operative information: Operation time (154.51 ± 33.37)min, Anastomosis time (26.88 ± 5.11) min; Intraoperative bleeding (66.34 ± 48.81) ml; First postoperative ambulation (1.07 ± 0.26) d, First postoperative flatus(3.07 ± 1.08)d, First postoperative diet(3.41 ± 1.07)d༌Postoperative hospital stay(8.76 ± 6.64)d, Total hospitalization cost (70804.00 ± 14282.05)RMB yuan; Differentiation degree: High and high-moderate(3,7.32%), Moderate and poor-moderate (24,58.54%)༌Poor differentiation (14,34.15%); Dissected lymph node (32.76 ± 13.16), Positive lymph node (2.39 ± 4.06); Pathological stage: IA (20,48.78%), IB (3,7.32%), IIA (4,9.76%), IIB (5,12.20%), IIIA (1,2.44%), IIIB (3,7.32%), IIIC (5,12.20%); Complications(n = 4): Lung infection(1,2.44%)༌Anastomotic leakage (1,2.44%༉༌Gastroparesis (2,4.88%༉;
Conclusion

It is safe and feasible in clinical treatment to apply the method of double needle-double layer continuous manual suture to complete digestive tract reconstruction in totally laparoscopic distal gastrectomy.
Prefrontal dopamine D1 receptor manipulation influences anxiety behavior and induces neuroinflammation within the hippocampus
Authors: Beyer Dominik K E , Mattukat Annika , Freund Nadja 
Published: May 2020

Abstract
Background - Prefrontal dopamine D1 receptor (D1R) mediates behavior related to anxiety, reward and memory, and is involved in inflammatory processes, all of which are affected in bipolar disorder. Patients with bipolar disorder show alternations in the dopamingergic and immune system. Interleukin-6 (IL-6), a pro-inflammatory cytokine, is increased in plasma samples, imaging studies and post mortem tissue. Manipulation of the D1R in the medial prefrontal cortex (mPFC) e.g. results in BD-like behavior. The purpose of the study is the investigation of the influence of D1R over-expression and its termination on the immune system and anxiety behavior in rats.Methods – Expression of the gene for D1R in glutamatergic neurons within the mPFC of male, adult rats was manipulated through an inducible (Tet.On) lentiviral vector. Anxiety behavior was studied in the elevated plus maze and marble burying test in ‘ON’ (D1R over-expression) and ‘OFF’ (termination of D1R over-expression) states. IL-6-positive cells were counted to identify the inflammatory state within several subregions of the hippocampus.Results - D1R ‘OFF’ subjects buried more marbles compared to D1R ‘ON’ and their respective control animals indicating an increased anxiety behavior. D1R ‘OFF’ animals reflected an elevated pro-inflammatory state in the hippocampus, in the CA3 and dentate gyrus especially. Consistently, inflammatory state in the whole hippocampus and anxiety behavior correlated positively, indicating a connection between anxiety and inflammatory state of the hippocampus.Conclusions – Behavioral and molecular findings support the association of D1R’s impact on anxiety and inflammation. In addition, by confirming an involvement of IL-6, the new animal model for bipolar disorder has been further validated.
Correlations between gender, age and the risk of withdrawal from peritoneal dialysis
Authors: Zhang Min Yan , He Miao , Wan Sheng , Ding Qiong Yan , Liu Lei , Xiong Fei , Hu Lin Yang 
Published: May 2020

Abstract
Background With the increasing incidence of end stage renal disease(ESRD),peritoneal dialysis(PD) has become the preferred method of kidney replacement therapy for an increasing number of patients with end stage renal disease due to its many advantages.The intent of this study was to explore the correlations between sex, age and risk of withdrawal from peritoneal dialysis.Methods All patients who underwent PD catheterization and initiated PD at Wuhan No.1 Hospital between 2013 and 2018 were screened.Clinical information of these patients was collected and compared according to gender and age,then was applied to the Cox proportional hazards model to determine the impact of factors of withdrawal from peritoneal dialysis.Results ①Hazard ratios(HRs) of withdrawal of PD associate with gender and age at initiation were 0.736(P = 0.289)、1.151༈P = 0.489༉respectively.Nonetheless,male patients under 60 years old had a 1.58-fold higher risk of withdrawal than others(HR 0.63,P = 0.031).②The withdrawal risk of patients with total Creatinine clearance rate (Ccr) above 60L/W was 82.4% higher than that of patients who did not meet the standard (HR 1.82,P = 0.005).③The withdrawal risk of patients with high D/P Creatinine༈Cr༉value which was calculated from peritoneal equilibration test(PET) were 2.06 times higher than low-average and high-average transport patients(HR2.06,P = 0.008).④Patients with serum albumin above 35 g/L were intended to withdraw from PD than those below 35 g/L (HR 0.56,P = 0.006).Conclusions There were significant differences in total KT/V, total Ccr,serum creatinine(Scr) and blood Urea nitrogen(BUN)among patients with PD of different gender and age.The analysis showed that male patients under 60 years old, Ccr, value of D/Pcr and serum albumin had a high correlation with the technical survival rates.While gender or age at PD initiation were not associated with technique survival,male patients under 60 years old had a 1.58-fold higher risk of withdrawal from PD than others.The outcome that the withdrawal risk of patients with Ccr above 60L/W was 82.4% higher than other patients who did not meet the standard suggested that Ccr was not suitable as an index for evaluating the adequacy of PD,especially for men under 60 years old.And patients with high D/Pcr value or with serum albumin under 35 g/L were related risk factors for technique survival.