bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Correlation Between Cone End Resistance (qc) And California Bearing Ratio (CBR) Of Land In Banjarbaru
Authors: Respati Rida , Cahyadi Hendra 
Published: April 2020

Abstract
All this time, the score of CBR is calculated according to qc score. Generally, planner usually refers to graph / nomogram which published on literature book, but the graph / nomogram on the book may not probably able to apply in all areas, including Banjarbaru. In this particular research, it aimed to make the graph or equation between CBR and Cone test in the cone area of 0.5 in2. The both tests used the same sample of water contents and density. The samples were taken in four areas in Banjarbaru; Balitra, Jalan Semeru (Semeru Street), Mandiangin Circuit, and Banjarbaru Asri Housing. There took soil samples in three points of every areas. By the test, obtained the correlation between CBR and Cone End Resistance (qc) on Banjarbaru area: CBR = 0.0545 qc + 2.618 and the qc score is between 50 kg/cm2 to 300 kg/cm2.
Education Synergism Environmental Based Learning: Nurul Islam Tamidung Batang Context
Authors: Mukhlishi Mukhlishi , Alam Suluh Mardika , Hidayatillah Yetti 
Published: April 2020

Abstract
Environment-based education builds student ability and behavior with the surrounding environment, the environment occupies an important position, the implication is the availaibility of a conducive environment both indoor and outdoor. This must be supported with environment health that is an essential part of the learners to learn and improve their cognitive, motoric and affective capabilities. This is a must to be created in an educational institution. Educational institutions always want to give different nuances that are accompanied by the quality of the institution itself. In essence, creating an educational synergism based on an environmentally-based learning perspective should be supported by environmental health for the sake of creating synergistic learning conditions.
Meaningful Learning Reconstruction for Millennial: Facing competition in the information technology era
Authors: Hanani Nurul 
Published: April 2020

Abstract
The rapidly expanding information age raises a variety of increasingly complex global problems and challenges. Tight competition and a boundless climate of competition will increasingly color the development of the world. To deal with this, the younger generation is required to be able to have a sufficient set of life skills. Meanwhile, education today is still considered too focused on the problem of knowledge. In order for the millennial generation to have sufficient understanding, education must be oriented towards giving meaning to students, as well as providing knowledge. This article will explore the reconstruction efforts of meaningful learning for millennial generations in the face of competition in the information age. Meaningful learning is directed at providing students with critical, innovative and creative thinking skills so that they are able to respond to various problems that will emerge in the future. Learning means constructivist style, where it emphasizes the ability of students to develop a comprehensive meaning from what they learn. Meaningful learning can be pursued by various methods or approaches, provided that they are student-oriented. Some methods that can be used include active learning, collaborative learning, cooperative learning, or problem-based learning. With some of these methods, of course traditional learning hegemony that has been emphasizing more on aspects of cognition will be replaced by constructivistic features that emphasize the skills of students in the learning process. That is, the greater the involvement of students in the learning process, the more skilled they will be in interpreting what they learn. Thus, they will be ready to compete competitively in this information era.
Environmental Cleaning Control Policy: Analyzing Cleanliness and Gardening Control in Pekanbaru, Indonesia
Authors: Dailiati Surya , Irawati Irawati , Marlinda Pebriana 
Published: April 2020

Abstract
The purpose of this study is to analyze the policy of environmental cleaning control in Pekanbaru City. The method used in this study is descriptive qualitative, which aims to analyze the policy of environmental cleaning control in Pekanbaru City. The collected data were analyzed with interactive model of Miles and Huberman. The study results indicated that the policy of Department of Cleanliness and Gardening of Pekanbaru City has been made and arranged as best as possible refer policy theory, but the cleanliness control policies cannot be implemented as maximum as possible because the existing policy is quite difficult to implement. Similarly, waste management through the Garbage Bank program in Pekanbaru City still has not been implemented effectively and optimally. This can be seen from the lack of public participation in the implementation of the Garbage Bank program.
Using POC Azolla Mycrophylla and Urea Fertilizer: Lettuce Plant (Lactuca Sativa L) Context
Authors: Lestari Sri Utami , Mutryarny Enny 
Published: April 2020

Abstract
The aim of the study was to obtain the best dose of POC Azolla microphylla in urea efficiency against the growth and production of lettuce. The study was conducted experimentally with non-factorial completely randomized design with 5 treatments and 4 replications each treatment consisting of 4 plants and 2 plants used as samples: A0 = Control (without treatment), A1 = POC treatment Azolla microphylla 30 ml l−1 + Urea 2 g plant−1, A2 = Treatment of POC Azolla microphylla 60 ml l−1+ Urea 1.5 g plant−1, A3 = Treatment of POC Azolla microphylla 90 ml l + Urea 1 g plant−1, A4 = POC treatment Azolla microphylla 120 ml l−1 + Urea 0.5 g plant−1. The results of the study were concluded; The combination of POC Azolla microphylla was able to streamline the administration of urea to stem diameter, number of leaves, fresh weight, consumption weight and dry weight of lettuce (Lactuca sativa L) and A4 treatment by giving POC Azolla microphylla 120 ml l−1 which was the best for urea efficiency.
Business and Risk Aspects in the era of Digital Information Technology University in Pekanbaru
Authors: Pahlawan Ryan , Widayat Prama 
Published: April 2020

Abstract
Education is a part of the business, if it will also be faced by the world of education, including the development of digital information technology. The ability of universities to manage the resources in adjusting to the progress of the digital world is crucial how they are able to influence students to select universities. All information must be digitally available through accreditation related websites, the existence of regular classes and evening classes for employees, inexpensive tuition fees, the location of the campus and courses offered.
Typical cases of destruction of the main hydraulic cylinders, causes of destruction and engineering solutions adopted for their prevention
Authors: Vorob’yev A , Gribkov A , Akinfiev A , Sinitsyna A 
Published: April 2020

Abstract
The problems of operation of hydraulic actuators in hydraulic press are considered. Design errors of hydraulic cylinders are identified. As the result of the simulation in the AnsysCFX, a new design with better strength properties is obtained, and the operational life of the hydraulic cylinder is increased. Also the pictures of the stressed-deformed state before and after structural changes are obtained.
Obtaining the maximum permissible gas content at the inlet to the ESP by computational fluid dynamics modeling
Authors: Petrov A , Sinitsyna A 
Published: April 2020

Abstract
Methods for increasing the operation stability of the electrical submersible pump (ESP) are listed. Examples of computational fluid dynamics (CFD) applications for designing and studying the flow part of the pump are given. The results of mesh convergence study, Pump performance curve, and dependences of head and hydraulic efficiency on gas content at the inlet, obtained by CFD methods, are presented. The results of CFD modeling are compared with experimental curves.
High-Pressure Positive-Displacement Hydraulic Pumps in Concrete Sample Testing Machines
Authors: Zyubin I , Cherkasskikh S , Akinfiev A , Babikova D 
Published: April 2020

Abstract
This article discusses a way to solve the problem of operational quality control of concrete in the construction of critical structures with the use of small-sized testing machines. To reduce the testing machines size, it is proposed to use a high-pressure hydraulic drive. As a promising way to control the machine, the practical experience is described of using a pump with a constant displacement, the drive of which uses an electronic frequency converter.
Improving the performance of a centrifugal vane pump by installing vortex generators on the suction surfaces of blades
Authors: Teplov O , Lomakin V 
Published: April 2020

Abstract
The influence of vortex generators mounting in the wet part of a centrifugal pump on its characteristics was investigated. Dependents of efficiency, cavitation characteristic, head and capacity are given. The vortex generators were mounted on the front edges of suction sides of the blades, where stall occurs, and a vortex is formed. The simulation results were compared with the characteristics obtained for the usual optimized flow part of the pump.
Obtaining of the optimal speed of the centrifugal pump
Authors: Shablovskiy A , Makhlaeva A , Shikova O 
Published: April 2020

Abstract
The work is devoted to the finding of the formula for calculating the optimal speed of the centrifugal pump. The structure, applications and main types of this vertical tank and its advantages in comparison to the horizontal tank are described. The figuring out of the formula is based on the conditions of maximum pump efficiency and it allows us to quickly assess the degree of non optimality of the pump when its operating frequency differs from the optimal frequency.
Variety of gas-dynamic turbulent configurations at internal flow in channels of structurally complex bodies
Authors: Kochetkov Yu , Borovik I , Podymova O , Protopopov A 
Published: April 2020

Annotation
For the study of turbulent configurations in complex channels, it is proposed to use the experimental method of mass entrainment in combination with theoretical analysis and mathematical description of the results obtained. The paper presents the results of numerous experiments conducted on high-enthalpy gas flows in nozzles of complex shape. Images were obtained that visualize the picture of the torsion-wave dynamic movement of gas flows, the presence of stable structured turbulent flow configurations, and the abrupt transition from one form of flow stability to another.
Investigation of the influence of wear in impeller seals on the axial force in double suction pumps
Authors: Isaev N , Budaev G , Danilov D , Dobrokhodov K 
Published: April 2020

Abstract
This article is devoted to the investigation of axial force on the rotor of the double suction centrifugal pump at unequal wear of impeller seals. The annular seal of the double suction centrifugal pump is considered as an object of the study. The distribution of the fields of velocities and pressure in the seals of the pump are obtained by numerical modeling. The leakage rate resulting from the simulation is compared to the existing formulas.
Improving electrical conductivity of leather surface: a new technology versus industrial applications
Authors: Florio Claudia , Calvanese Gianluigi , Naviglio Biagio , Sarno Maria , Iuliano Mariagrazia , Ciambelli Paolo , De Pasquale Salvatore 
Published: April 2020

Abstract
The present study takes into account the consumer requirement of an even more massive use of touch screen devices, where the leather has to compete with the modern textile fibers in terms of technological performances, with particular reference to the newest technologies for the production of conductive gloves and other kinds of conductive goods, like shoes, garments, and others. Most of the known technologies able to provide materials with a unique ability to discharge static electricity and conductivity comparable with the human body concern the use of textile fibers. On the other hand, the goal of the present work is to delve into the application of technologies for leather matrix, with particular reference to the use of carbon-based nanomaterials, and attention to economical and/or practical aspects.
Early-Life Adversities and Recalcitrant Smoking in Midlife: An Examination of Gender and Life-Course Pathways
Authors: Lee Chioun , Harari Lexi , Park Soojin 
Published: April 2020

Abstract

Background
Little is known about life-course factors that explain why some individuals continue smoking despite having smoking-related diseases.

Purpose
We examined (a) the extent to which early-life adversities are associated with the risk of recalcitrant smoking, (b) psychosocial factors that mediate the association, and (c) gender differences in the associations.

Methods
Data were from 4,932 respondents (53% women) who participated in the first and follow-up waves of the Midlife Development in the U.S. National Survey. Early-life adversities include low socioeconomic status (SES), abuse, and family instability. Potential mediators include education, financial strain, purpose in life, mood disorder, family problems/support, and marital status. We used sequential logistic regression models to estimate the effect of early-life adversities on the risk of each of the three stages on the path to recalcitrant smoking (ever-smoking, smoking-related illness, and recalcitrant smoking).

Results
For women, low SES (odds ratio [OR] = 1.29; 1.06–1.55) and family instability (OR = 1.73; 1.14–2.62) are associated with an elevated risk of recalcitrant smoking. Education significantly reduces the effect of childhood SES, yet the effect of family instability remains significant even after accounting for life-course mediators. For men, the effect of low SES on recalcitrant smoking is robust (OR = 1.48; 1.10–2.00) even after controlling for potential mediators. There are noteworthy life-course factors that independently affect recalcitrant smoking: for both genders, not living with a partner; for women, education; and for men, family problems.

Conclusions
The findings can help shape intervention programs that address the underlying factors of recalcitrant smoking.
Spontaneous Early Withdrawal Behaviors after Chronic 24-hour Free-Choice Access to Ethanol
Authors: Hauser Sheketha R , Smith Rebecca J , Toalston Jamie E , Rodd Zachary A , McBride William J , Bell Richard L 
Published: April 2020

AbstractAimsAbstinence after chronic alcohol consumption leads to withdrawal symptoms, which are exacerbated after repeated cycles of relapse. This study examined withdrawal-like behaviors after chronic ethanol drinking, with or without repeated cycles of deprivation.MethodsMale alcohol-preferring (P) rats had access to continuous ethanol (CE), chronic ethanol with repeated deprivation (RD), or remained ethanol naïve (EN). The RD group experienced seven cycles of 2 weeks of deprivation and 2 weeks of re-exposure to ethanol after an initial 6 weeks of ethanol access. Withdrawal was measured after an initial 24 h of ethanol re-exposure in the RD group, which coincided with the same day of ethanol access in the CE group. Withdrawal-like behavior was measured by (a) ethanol intake during the initial 24 h of re-exposure, (b) locomotor activity (LMA) in a novel field 9–13 h after removal of ethanol at the beginning of the fifth re-exposure cycle and (c) acoustic startle responding (ASR) 8–15 h after removal of ethanol at the beginning of the sixth re-exposure cycle.ResultsThe RD rats displayed a 1-h alcohol deprivation effect (ADE) (temporary ethanol increase), relative to CE rats, during the first to fourth and seventh re-exposure cycles. RD and CE rats displayed significant increases in LMA than EN rats. Regarding ASR, RD rats displayed significantly greater ASR relative to EN rats.ConclusionThis study confirms that P rats meet the animal model criterion for ethanol-associated dependence, without a reliance on either behavioral (limited fluid access) or pharmacological (seizure threshold manipulation) challenges.
An in silico model of LINE-1-mediated neoplastic evolution
Authors: LeBien Jack , McCollam Gerald , Atallah Joel 
Published: April 2020

Abstract

Motivation
Recent research has uncovered roles for transposable elements (TEs) in multiple evolutionary processes, ranging from somatic evolution in cancer to putatively adaptive germline evolution across species. Most models of TE population dynamics, however, have not incorporated actual genome sequence data. The effect of site integration preferences of specific TEs on evolutionary outcomes and the effects of different selection regimes on TE dynamics in a specific genome are unknown. We present a stochastic model of LINE-1 (L1) transposition in human cancer. This system was chosen because the transposition of L1 elements is well understood, the population dynamics of cancer tumors has been modeled extensively, and the role of L1 elements in cancer progression has garnered interest in recent years.

Results
Our model predicts that L1 retrotransposition (RT) can play either advantageous or deleterious roles in tumor progression, depending on the initial lesion size, L1 insertion rate and tumor driver genes. Small changes in the RT rate or set of driver tumor-suppressor genes (TSGs) were observed to alter the dynamics of tumorigenesis. We found high variation in the density of L1 target sites across human protein-coding genes. We also present an analysis, across three cancer types, of the frequency of homozygous TSG disruption in wild-type hosts compared to those with an inherited driver allele.

Availability and implementation
Source code is available at https://github.com/atallah-lab/neoplastic-evolution.

Contact
jlebien@uno.edu

Supplementary information
Supplementary data are available at Bioinformatics online.
scDoc: correcting drop-out events in single-cell RNA-seq data
Authors: Ran Di , Zhang Shanshan , Lytal Nicholas , An Lingling 
Published: April 2020

AbstractMotivationSingle-cell RNA-sequencing (scRNA-seq) has become an important tool to unravel cellular heterogeneity, discover new cell (sub)types, and understand cell development at single-cell resolution. However, one major challenge to scRNA-seq research is the presence of ‘drop-out’ events, which usually is due to extremely low mRNA input or the stochastic nature of gene expression. In this article, we present a novel single-cell RNA-seq drop-out correction (scDoc) method, imputing drop-out events by borrowing information for the same gene from highly similar cells.ResultsscDoc is the first method that directly involves drop-out information to accounting for cell-to-cell similarity estimation, which is crucial in scRNA-seq drop-out imputation but has not been appropriately examined. We evaluated the performance of scDoc using both simulated data and real scRNA-seq studies. Results show that scDoc outperforms the existing imputation methods in reference to data visualization, cell subpopulation identification and differential expression detection in scRNA-seq data.Availability and implementationR code is available at https://github.com/anlingUA/scDoc.Supplementary informationSupplementary data are available at Bioinformatics online.
Human-induced pluripotent stem cells for modelling metabolic perturbations and impaired bioenergetics underlying cardiomyopathies
Authors: Ramachandra Chrishan J A , Chua Jasper , Cong Shuo , Kp Myu Mai Ja , Shim Winston , Wu Joseph C , Hausenloy Derek J 
Published: April 2020

Abstract
Normal cardiac contractile and relaxation functions are critically dependent on a continuous energy supply. Accordingly, metabolic perturbations and impaired mitochondrial bioenergetics with subsequent disruption of ATP production underpin a wide variety of cardiac diseases, including diabetic cardiomyopathy, dilated cardiomyopathy, hypertrophic cardiomyopathy, anthracycline cardiomyopathy, peripartum cardiomyopathy, and mitochondrial cardiomyopathies. Crucially, there are no specific treatments for preventing the onset or progression of these cardiomyopathies to heart failure, one of the leading causes of death and disability worldwide. Therefore, new treatments are needed to target the metabolic disturbances and impaired mitochondrial bioenergetics underlying these cardiomyopathies in order to improve health outcomes in these patients. However, investigation of the underlying mechanisms and the identification of novel therapeutic targets have been hampered by the lack of appropriate animal disease models. Furthermore, interspecies variation precludes the use of animal models for studying certain disorders, whereas patient-derived primary cell lines have limited lifespan and availability. Fortunately, the discovery of human-induced pluripotent stem cells has provided a promising tool for modelling cardiomyopathies via human heart tissue in a dish. In this review article, we highlight the use of patient-derived iPSCs for studying the pathogenesis underlying cardiomyopathies associated with metabolic perturbations and impaired mitochondrial bioenergetics, as the ability of iPSCs for self-renewal and differentiation makes them an ideal platform for investigating disease pathogenesis in a controlled in vitro environment. Continuing progress will help elucidate novel mechanistic pathways, and discover novel therapies for preventing the onset and progression of heart failure, thereby advancing a new era of personalized therapeutics for improving health outcomes in patients with cardiomyopathy.
The Simons Genome Diversity Project: A Global Analysis of Mobile Element Diversity
Authors: Watkins W Scott , Feusier Julie E , Thomas Jainy , Goubert Clement , Mallick Swapon , Jorde Lynn B 
Published: April 2020

AbstractOngoing retrotransposition of Alu, LINE-1, and SINE–VNTR–Alu elements generates diversity and variation among human populations. Previous analyses investigating the population genetics of mobile element insertions (MEIs) have been limited by population ascertainment bias or by relatively small numbers of populations and low sequencing coverage. Here, we use 296 individuals representing 142 global populations from the Simons Genome Diversity Project (SGDP) to discover and characterize MEI diversity from deeply sequenced whole-genome data. We report 5,742 MEIs not originally reported by the 1000 Genomes Project and show that high sampling diversity leads to a 4- to 7-fold increase in MEI discovery rates over the original 1000 Genomes Project data. As a result of negative selection, nonreference polymorphic MEIs are underrepresented within genes, and MEIs within genes are often found in the transcriptional orientation opposite that of the gene. Globally, 80% of Alu subfamilies predate the expansion of modern humans from Africa. Polymorphic MEIs show heterozygosity gradients that decrease from Africa to Eurasia to the Americas, and the number of MEIs found uniquely in a single individual are also distributed in this general pattern. The maximum fraction of MEI diversity partitioned among the seven major SGDP population groups (FST) is 7.4%, similar to, but slightly lower than, previous estimates and likely attributable to the diverse sampling strategy of the SGDP. Finally, we utilize these MEIs to extrapolate the primary Native American shared ancestry component to back to Asia and provide new evidence from genome-wide identical-by-descent genetic markers that add additional support for a southeastern Siberian origin for most Native Americans.