bluuebunny/crossref_metadata_2025_split huggingface dataset:
Data analysis and simulation of the Lillgrund wind farm
Authors: Sebastiani Alessandro , Castellani Francesco , Crasto Giorgio , Segalini Antonio 
Published: November 2020

AbstractThe power production of the Lillgrund wind farm has been investigated by means of SCADA data covering almost 10 years of operation, wake models and numerical simulation tools, such as WindSim, OpenFOAM and ORFEUS. The analysis of the SCADA data provided the quantification of wake losses and of blockage effects, results that enable a benchmark to assess the uncertainty of other numerical methods of industrial use. The results have been analysed in terms of global array efficiency for different wind directions, wind velocity and stratification conditions. A comparison of the present results with the Jensen and Ainsle models indicated that the two used wake models are affected by an error of about 8–10% in the estimation of the array efficiency, while the error does not vary significantly when using numerical tools such as ORFEUS, WindSim and OpenFOAM. By comparing wind statistics available before the park construction, an assessment of the blockage of the Lillgrund farm was performed with contrasting results from the other numerical tools, highlighting how challenging is to assess farm blockage with current industrial settings.
Use and Impact of Artificial Intelligence on Climate Change Adaptation in Africa
Authors: Rutenberg Isaac , Gwagwa Arthur , Omino Melissa 
Published: November 2020

AbstractAlthough Climate Change is a global phenomenon, the impact in Africa is anticipated to be greater than in many other parts of the world. This expectation is supported by many factors, including the relatively low shock tolerance of many African countries and the relatively high percentage of African workers engaged in the agricultural sector. High-income countries are increasingly turning their focus to climate change adaptation, and Artificial Intelligence (AI) is a critical tool in those efforts. Algorithms using AI are making better predictions on the short- and long-term effects of climate change, including predictions related to weather patterns, floods and droughts, and human migration patterns. It is not clear, however, that Africa is (or will be) maximally benefitting from those AI tools, particularly since they are largely developed by highly developed countries using data sets that are specific to those same countries. It is therefore important to characterize the efforts underway to use AI in a way that specifically benefits Africa in climate change adaptation. These efforts include projects undertaken physically in Africa as well as those that have Africa as their focus. In exploring AI projects in or about Africa, this chapter also looks at the sufficiency of such efforts and the variety of approaches taken by researchers working with AI to address climate change in Africa.
Indirect $$ \mathcal{CP} $$ probes of the Higgs-top-quark interaction: current LHC constraints and future opportunities
Authors: Bahl Henning , Bechtle Philip , Heinemeyer Sven , Katzy Judith , Klingl Tobias , Peters Krisztian , Saimpert Matthias , Stefaniak Tim , Weiglein Georg 
Published: November 2020

AbstractThe$$ \mathcal{CP} $$CPstructure of the Higgs boson in its coupling to the particles of the Standard Model is amongst the most important Higgs boson properties which have not yet been constrained with high precision. In this study, all relevant inclusive and differential Higgs boson measurements from the ATLAS and CMS experiments are used to constrain the$$ \mathcal{CP} $$CP-nature of the top-Yukawa interaction. The model dependence of the constraints is studied by successively allowing for new physics contributions to the couplings of the Higgs boson to massive vector bosons, to photons, and to gluons. In the most general case, we find that the current data still permits a significant$$ \mathcal{CP} $$CP-odd component in the top-Yukawa coupling. Furthermore, we explore the prospects to further constrain the$$ \mathcal{CP} $$CPproperties of this coupling with future LHC data by determiningtHproduction rates independently from possible accompanying variations of the$$ t\overline{t}H $$tt¯Hrate. This is achieved via a careful selection of discriminating observables. At the HL-LHC, we find that evidence fortHproduction at the Standard Model rate can be achieved in the Higgs to diphoton decay channel alone.
SL(2, ℤ) action on QFTs with ℤ2 symmetry and the Brown-Kervaire invariants
Authors: Bhardwaj Lakshya , Lee Yasunori , Tachikawa Yuji 
Published: November 2020

AbstractWe consider an analogue of Witten’s SL(2,ℤ) action on three-dimensional QFTs with U(1) symmetry for 2k-dimensional QFTs with ℤ2(k −1)-form symmetry. We show that the SL(2,ℤ) action only closes up to a multiplication by an invertible topological phase whose partition function is the Brown-Kervaire invariant of the spacetime manifold. We interpret it as part of the SL(2,ℤ) anomaly of the bulk (2k+ 1)-dimensional ℤ2gauge theory.
Shared extracellular vesicle miRNA profiles of matched ductal pancreatic adenocarcinoma organoids and blood plasma samples show the power of organoid technology
Authors: Zeöld Anikó , Sándor Gyöngyvér Orsolya , Kiss Anna , Soós András Áron , Tölgyes Tamás , Bursics Attila , Szűcs Ákos , Harsányi László , Kittel Ágnes , Gézsi András , Buzás Edit I. , Wiener Zoltán 
Published: November 2020

AbstractExtracellular vesicles (EV) are considered as a promising diagnostic tool for pancreatic ductal adenocarcinoma (PDAC), a disease with a poor 5-year survival that has not improved in the past years. PDAC patient-derived 3D organoids maintain the intratumoral cellular heterogeneity, characteristic for the tumor in vivo.Thus, they represent an ideal in vitro model system to study human cancers. Here we show that the miRNA cargo of EVs from PDAC organoids largely differs among patients. However, we detected a common set of EV miRNAs that were present in matched organoids and blood plasma samples of individual patients. Importantly, the levels of EV miR-21 and miR-195 were higher in PDAC blood EV preparations than in healthy controls, albeit we found no difference compared to chronic pancreatitis (CP) samples. In addition, here we report that the accumulation of collagen I, a characteristic change in the extracellular matrix (ECM) in both CP and PDAC, largely increases EV release from pancreatic ductal organoids. This provides a possible explanation why both CP and PDAC patient-derived plasma samples have an elevated amount of CD63 + EVs. Collectively, we show that PDAC patient-derived organoids represent a highly relevant model to analyze the cargo of tumor cell-derived EVs. Furthermore, we provide evidence that not only driver mutations, but also changes in the ECM may critically modify EV release from pancreatic ductal cells.
Postorthodontic lower incisor and canine inclination and labial gingival recession in adult patients
Authors: Kalina Edyta , Zadurska Małgorzata , Górski Bartłomiej 
Published: November 2020

Abstract
Purpose
The goal was to determine whether changes in the inclination of lower incisors and canines upon orthodontic treatment with fixed appliances poses a threat for labial gingival recession in adult patients.

Methods
The sample of this prospective clinical trial consisted of 32 adult patients (mean age 25.08 ±6.50 years) treated with fixed appliances. Plaque and bleeding indices, probing pocket depth, clinical attachment level, gingival recession height (GR) and width (GRW), gingival thickness (GT), and keratinized tissue width were clinically recorded, while cone beam computed tomography (CBCT) was used to evaluate teeth inclination before (T1) and after treatment (T2). Oral hygiene, brushing habits, and smoking were controlled.

Results
During orthodontic treatment on 15 (8.33%) teeth (10 incisors and 5 canines), spontaneous complete improvement of pre-existing GR was observed. On 2 incisors, GR decreased and on 3 teeth GR did not change. Moreover, 1 incisor presented an increased GR, while 2 teeth developed new defects. Mean GR, GRW, and GT decreased significantly only on the incisors. Proclination of incisors and canines during treatment (compared with retroclination of the teeth) implicated a lower reduction in GR at T2: 0.19 mm (p = 0.034) and 0.18 mm (p = 0.037), respectively. Multiple regression analysis confirmed that more tooth proclination was associated with a higher risk for an increase in GR (p < 0.00).

Conclusion
Properly planned changes in lower incisor and canine inclination can be carried out in adult patients without posing a high risk to labial gingival recessions if the individual periodontal biotype is respected. The reported outcomes underscore the orthodontic principle to keep tooth roots inside the alveolar bone.
A thermodynamic approach to rate-type models in deformable ferroelectrics
Authors: Giorgi Claudio , Morro Angelo 
Published: November 2020

AbstractThe purpose of the paper is to establish vector-valued rate-type models for the hysteretic properties in deformable ferroelectrics within the framework of continuum thermodynamics. Unlike electroelasticity and piezoelectricity, in ferroelectricity both the polarization and the electric field are simultaneously independent variables so that the constitutive functions depend on both. This viewpoint is naturally related to the fact that an hysteresis loop is a closed curve in the polarization–electric field plane. For the sake of generality, the deformation of the material and the dependence on the temperature are allowed to occur. The constitutive functions are required to be consistent with the principle of objectivity and the second law of thermodynamics. Objectivity implies that the constitutive equations are form invariant within the set of Euclidean frames. Among other results, the second law requires a general property on the relation between the polarization and the electric field via a differential equation. This equation shows a dependence fully characterized by two quantities: the free energy and a function which is related to the dissipative character of the hysteresis. As a consequence, different hysteresis models may have the same free energy. Models compatible with thermodynamics are then determined by appropriate selections of the free energy and of the dissipative part. Correspondingly, major and minor hysteretic loops are plotted.
A model identifying characteristics predictive of successful pelvic floor muscle training outcomes among women with stress urinary incontinence
Authors: Brooks Kaylee C. L. , Varette Kevin , Harvey Marie-Andrée , Robert Magali , Brison Robert J. , Day Andrew , Baker Kevin , Della Zazzera Vincent , Sauerbrei Eric , McLean Linda 
Published: November 2020

Abstract
Introduction and hypothesis
The aim of this study was to prospectively identify aspects of baseline demographic, clinical, and pelvic morphology of women with stress urinary incontinence (SUI) that are predictive of cure with physiotherapist-supervised pelvic floor muscle training (PFMT).

Methods
Women ≥18 years old with SUI were recruited from urogynecology and pelvic health physiotherapy clinics. Participants completed a 3-day bladder diary, the International Consultation on Incontinence Questionnaire Urinary Incontinence Short Form (ICIQ-UI-SF), a standardized pad test, manual assessment of pelvic floor muscle (PFM) strength and tone, and transperineal ultrasound (TPUS) assessment of their urogenital structures at rest while in a supine position and standing, and during contraction, straining, and coughing. Participants attended six physiotherapy sessions over 12 weeks and performed a home PFMT program. The assessment was repeated after the intervention; cure was defined as a dry (≤2 g) pad test.

Results
Seventy-seven women aged 50 (±10) years completed the protocol; 38 (49%) were deemed cured. Based on univariate testing, four predictors were entered into a binary logistic regression model: ICIQ-UI-SF, PFM tone, bladder neck (BN) height in a quiet standing position, and BN height during a cough in a standing position. The model was significant (p < 0.001), accurately classifying outcome in 74% of participants. The model, validated through bootstrapping, performed moderately, with the area under the receiver operating characteristic curve = 0.80 (95% CI: 0.69–0.90; p = 0.00), and with 70% sensitivity and 75% specificity.

Conclusions
Women with better bladder support in a standing position and less severe symptoms were most likely to be cured with PFMT.

Clinical trial registration
#NCT01602107.
Fluorescence polarization immunoassay for the determination of diclofenac in wastewater
Authors: Raysyan Anna , Moerer Robin , Coesfeld Bianca , Eremin Sergei A. , Schneider Rudolf J. 
Published: November 2020

AbstractPharmacologically active compounds are often detected in wastewater and surface waters. The nonsteroidal anti-inflammatory drug diclofenac (DCF) was included in the European watch list of substances that requires its environmental monitoring in the member states. DCF may harmfully influence the ecosystem already at concentrations ≤ 1 μg L−1. The fast and easy quantification of DCF is becoming a subject of global importance. Fluorescence polarization immunoassay (FPIA) is a homogeneous mix-and-read method which does not require the immobilization of reagents. FPIA can be performed in one phase within 20–30 min, making it possible to analyse wastewater without any complicated pre-treatment. In this study, new tracer molecules with different structures, linking fluorophores to derivatives of the analyte, were synthesized, three homologous tracers based on DCF, two including a C6 spacer, and one heterologous tracer derived from 5-hydroxy-DCF. The tracer molecules were thoroughly assessed for performance. Regarding sensitivity of the FPIA, the lowest limit of detection reached was 2.0 μg L−1 with a working range up to 870 μg L−1. The method was validated for real wastewater samples against LC-MS/MS as reference method with good agreement of both methods.
Impact of processing degree on fermentation profile and chemopreventive effects of oat and waxy barley in LT97 colon adenoma cells
Authors: Schlörmann W. , Keller F. , Zetzmann S. , Lorkowski S. , Dawczynski C. , Glei M. 
Published: November 2020

AbstractThe chemopreventive effects of β-glucan-rich cereals such as oat and barley (beta®barley) have been examined previously, but studies comparing fermentation characteristics and chemopreventive effects of oat and barley of different processing stages are rare. Therefore, the present study aims at investigating the fermentation end points (pH values, concentrations of short-chain fatty acids (SCFA) and ammonia) in fermentation supernatants (FS) obtained from differently processed oat and barley samples (kernels, thick and thin flakes). Chemopreventive effects of FS, such as growth inhibition, apoptosis, and induction of cell cycle- and redox-relevant genes (p21, SOD2), were analysed in LT97 colon adenoma cells. After fermentation, pH values were reduced (∆ pH − 1.3, on average) and SCFA concentrations were increased (∆ + 59 mmol/L, on average) with a shift towards butyrate formation in FS obtained from oat and barley samples compared to the fermentation negative control (FS blank). Ammonia was reduced more effectively in FS obtained from barley (∆ − 4.6 mmol/L, on average) than from oat samples (∆ − 1.0 mmol/L, on average). Treatment of LT97 cells with FS resulted in a time- and dose-dependent reduction of cell number, an increase in caspase-3 activity (up to 9.0-fold after 24 h, on average) and an induction of p21 (2.1-fold, on average) and SOD2 (2.3-fold, on average) mRNA expression, while no genotoxic effects were observed. In general, the results indicate no concrete effect of the type of cereal or processing stage on fermentation and chemopreventive effects of oat and barley.
Properties and structure of high temperature resistant cyanate ester/polyethersulfone blends using solvent-free toughening approach
Authors: Amirova Lyaysan , Schadt Fabian , Grob Markus , Brauner Christian , Ricard Thomas , Wille Tobias 
Published: November 2020

AbstractA high temperature resistant novolac cyanate ester was blended with polyethersulfone (PES) with different molecular weights using the solvent-free approach. The phase separation, curing behavior and thermal properties were studied using hot stage microscopy, differential scanning calorimetry and dynamic mechanical analysis. Results showed the difference in the morphology for blends with different molecular weight PES explained by possible network formation. The influence of PES content on the glass transition temperature and mechanical properties was investigated. The most significant toughening effect (increase of 132% in fracture toughness) was achieved on a functionalized low molecular weight PES (20 parts per hundred of resin, phr). Rheology investigation allowed to estimate the optimal content of PES (15 phr) for further prepreg manufacturing.
Evaluating anemia using contrast-enhanced spectral detector CT of the chest in a large cohort of 522 patients
Authors: Zopfs D. , Rinneburger M. , Pinto dos Santos D. , Reimer R. P. , Laukamp K. R. , Maintz D. , Lennartz S. , Große Hokamp N. 
Published: November 2020

Abstract
Objectives
The blood of patients with anemia demonstrates distinctly lower attenuation in unenhanced CT images. However, the frequent usage of intravenous contrast hampers evaluation of anemia. Spectral detector computed tomography (SDCT) allows for reconstruction of virtual non-contrast images (VNC) from contrast-enhanced data (CE). The purpose of this study was to evaluate whether VNC allow for prediction of anemia.

Methods
Five hundred twenty-two patients with CE-SDCT of the chest and accessible serum hemoglobin (HbS) were retrospectively included. Patients were assigned to three groups (severe anemia, moderate/mild anemia, and healthy) based on recent lab tests (≤ 7 days) for HbS following gender and the WHO definition of anemia. CT attenuation was determined using two ROI in the left ventricular lumen and one ROI in the descending thoracic aorta. ROI were placed on CE and copied to VNC. ANOVA, linear regression, and receiver operating characteristics were used for statistic evaluation.

Results
Average HbS was 11.6 ± 2.4 g/dl. Attenuation on VNC showed significant differences between healthy patients, patients with mild/moderate anemia, and severely anemic patients (all p ≤ 0.05). Applying cutoffs of 39.2/37.6 HU and 33.6/32.7 HU allowed to differentiate between healthy, mild/moderately, and severely anemic men/women (AUC 0.857/0.833 and 0.879/0.932). A linear relationship between HbS and attenuation on VNC was established (r2 = 0.54, HbS = − 0.875 + 0.329 × HU).

Conclusions
An approximation of HbS and presence of anemia can be conducted based on simple attenuation measurements in contrast-enhanced SDCT examinations enabled by VNC imaging.

Key Points
• While the attenuation of blood is a previously described biomarker for anemia in non-contrast images, virtual non-contrast images from spectral detector CT circumvent this limitation and allow for diagnosis of anemia in contrast-enhanced scans.
• Attenuation of blood in virtual non-contrast images derived from spectral detector CT shows a moderate correlation to serum hemoglobin levels.
• Presence of anemia be estimated in virtual non-contrast images using proposed cutoffs of 39.2 HU and 37.6 HU for men and women, respectively, to differentiate between healthy and anemic patients.
Dynamics and buckling loads for a vibrating damped Euler–Bernoulli beam connected to an inhomogeneous foundation
Authors: Abramian Andrei K. , Vakulenko Sergei A. , van Horssen Wim T. , Lukichev Dmitry V. 
Published: November 2020

AbstractIn this paper, the dynamics and the buckling loads for an Euler–Bernoulli beam resting on an inhomogeneous elastic, Winkler foundation are studied. An analytical, asymptotic method is proposed to determine the stability of the Euler–Bernoulli beam for various types of inhomogeneities in the elastic foundation taking into account different types of damping models. Based on the Rayleigh variation principle, beam buckling loads are computed for cases of harmonically perturbed types of inhomogeneities in the elastic foundation, for cases of point inhomogeneities in the form of concentrated springs in the elastic foundation, and for cases with rectangular inclusions in the elastic foundation. The investigation of the beam dynamics shows the possibility of internal resonances for particular values of the beam rigidity and longitudinal force. Such types of resonances, which are usually typical for nonlinear systems, are only possible for the beam due to its inhomogeneous foundation. The occurrence of so-called added mass effects near buckling instabilities under the influence of damping have been found. The analytical expressions for this “added mass” effect have been obtained for different damping models including space hysteresis types. This effect arises as a result of an interaction between the main mode, which is close to instability, and all the other stable modes of vibration.
Compactness and convergence rates in the combinatorial integral approximation decomposition
Authors: Kirches Christian , Manns Paul , Ulbrich Stefan 
Published: November 2020

AbstractThe combinatorial integral approximation decomposition splits the optimization of a discrete-valued control into two steps: solving a continuous relaxation of the discrete control problem, and computing a discrete-valued approximation of the relaxed control. Different algorithms exist for the second step to construct piecewise constant discrete-valued approximants that are defined on given decompositions of the domain. It is known that the resulting discrete controls can be constructed such that they converge to a relaxed control in the $$\hbox {weak}^*$$

weak
∗

topology of $$L^\infty $$

L
∞

if the grid constant of this decomposition is driven to zero. We exploit this insight to formulate a general approximation result for optimization problems, which feature discrete and distributed optimization variables, and which are governed by a compact control-to-state operator. We analyze the topology induced by the grid refinements and prove convergence rates of the control vectors for two problem classes. We use a reconstruction problem from signal processing to demonstrate both the applicability of the method outside the scope of differential equations, the predominant case in the literature, and the effectiveness of the approach.
A novel identification procedure from ambient vibration data
Authors: Di. Matteo A. , Masnata C. , Russotto S. , Bilello C. , Pirrotta A. 
Published: November 2020

AbstractAmbient vibration modal identification, also known as Operational Modal Analysis, aims to identify the modal properties of a structure based on vibration data collected when the structure is under its operating conditions, i.e., no initial excitation or known artificial excitation. This procedure for testing and/or monitoring historic buildings, is particularly attractive for civil engineers concerned with the safety of complex historic structures.
However, since the external force is not recorded, the identification methods have to be more sophisticated and based on stochastic mechanics. In this context, this contribution will introduce an innovative ambient identification method based on applying the Hilbert Transform, to obtain the analytical representation of the system response in terms of the correlation function. In particular, it is worth stressing that the analytical signal is a complex representation of a time domain signal: the real part is the time domain signal itself, while the imaginary part is its Hilbert transform. A 3DOF numerical example will be presented to show the accuracy of the proposed procedure, and comparisons with data from other methods assess the reliability of the approach. Finally, the identification method will be extended to the real case study of the Chiaramonte Palace, a historic building located in Palermo and known as “Steri”.