bluuebunny/crossref_metadata_2025_split huggingface dataset:
An architectonic type principle in the development of laminar patterns of cortico-cortical connections
Authors: Beul Sarah F. , Goulas Alexandros , Hilgetag Claus C. 
Published: December 2019

AbstractStructural connections between cortical areas form an intricate network with a high degree of specificity. Many aspects of this complex network organization in the adult mammalian cortex are captured by an architectonic type principle, which relates structural connections to the architectonic differentiation of brain regions. In particular, the laminar patterns of projection origins are a prominent feature of structural connections that varies in a graded manner with the relative architectonic differentiation of connected areas in the adult brain. Here we show that the architectonic type principle is already apparent for the laminar origins of cortico-cortical projections in the immature cortex of the macaque monkey. We find that prenatal and neonatal laminar patterns correlate with cortical architectonic differentiation, and that the relation of laminar patterns to architectonic differences between connected areas is not substantially altered by the complete loss of visual input. Moreover, we find that the amount of change in laminar patterns that projections undergo during development varies in proportion to the relative architectonic differentiation of the connected areas. Hence, it appears that initial biases in laminar projection patterns become progressively strengthened by later developmental processes. These findings suggest that early neurogenetic processes during the formation of the brain are sufficient to establish the characteristic laminar projection patterns. This conclusion is in line with previously suggested mechanistic explanations underlying the emergence of the architectonic type principle and provides further constraints for exploring the fundamental factors that shape structural connectivity in the mammalian brain.
Functional connectivity differences in early infancy precede autism symptoms: a multivariate pattern analysis
Authors: Dickinson Abigail , Daniel Manjari , Marin Andrew , Goanker Bilwaj , Dapretto Mirella , McDonald Nicole M. , Jeste Shafali 
Published: December 2019

AbstractFunctional brain connectivity is altered in children and adults with autism spectrum disorder (ASD). Mapping pre-symptomatic functional disruptions in ASD could identify infants based on neural risk, providing a crucial opportunity to mediate outcomes before behavioral symptoms emerge.Here we quantify functional connectivity using scalable EEG measures of oscillatory phase coherence (6-12Hz). Infants at high and low familial risk for ASD (N=65) underwent an EEG recording at 3 months of age and were assessed for ASD symptoms at 18 months using the Autism Diagnostic Observation Schedule-Toddler Module. Multivariate pattern analysis was used to examine early functional patterns that are associated with later ASD symptoms.Support vector regression (SVR) algorithms accurately predicted observed ASD symptoms at 18 months from EEG data at 3 months (r=0.76, p=0.02). Specifically, lower frontal connectivity and higher right temporo-parietal connectivity predicted higher ASD symptoms. The SVR model did not predict non-verbal cognitive abilities at 18 months (r=0.15, p=0.36), suggesting specificity of these brain alterations to ASD.These data suggest that frontal and temporo-parietal dysconnectivity play important roles in the early pathophysiology of ASD. Early functional differences in ASD can be captured using EEG during infancy and may inform much-needed advancements in the early detection of ASD.
Transinfection of buffalo flies (Haematobia exigua) with Wolbachia and effect on host biology
Authors: Madhav Mukund , Brown Geoff , Morgan Jess A.T , Asgari Sassan , McGraw Elizabeth A. , James Peter 
Published: December 2019

AbstractA widespread insect endosymbiont Wolbachia is currently of much interest for use in novel strategies for the control of insect pests and blocking transmission of insect-vectored diseases. Wolbachia-induced effects can vary from beneficial to detrimental depending on host biology and the genetic background of the infecting strains. As a first step towards investigating the potential of Wolbachia for use in the biocontrol of buffalo flies (BF), embryos, pupae, and adult female BF were injected with three different Wolbachia strains (wAlbB, wMel and wMelPop). BF eggs were not easily injected because of their tough outer chorion and embryos were frequently damaged resulting in less than 1% hatch rate of microinjected eggs. No Wolbachia infection was recorded in flies successfully reared from injected eggs. Adult and pupal injection gave a much higher survival rate and resulted in somatic infection and germinal tissue infection in surviving flies with transmission to the succeeding generations on a number of occasions. Investigations of infection dynamics in flies from injected pupae confirmed that Wolbachia were increasing in numbers in BF somatic tissues and ovarian infections were confirmed with wMel and wMelPop in some instances, though not with wAlbB. Measurement of fitness traits indicated reduced longevity, decreased and delayed adult emergence, and reduced fecundity in Wolbachia-infected flies in comparison to mock-injected flies. Furthermore, fitness effects varied according to the Wolbachia strain injected with most marked reductions seen in the wMelPop-injected flies and least severe effects seen with the wAlbB strain.
Effects of budget system use on innovation performance
Authors: Beuren Ilse Maria , Souza Guilherme Eduardo de , Bernd Daniele Cristina 
Published: December 2019

PurposeThe purpose of this paper is to analyze the effects of the budget system use on innovation performance concerning products and processes in Brazilian companies.Design/methodology/approachA survey was conducted in companies with economic activities addressed by the Brazilian Industrial Research of Technological Innovation carried out by the Brazilian Institute for Geography and Statistics, which provided 111 valid answers. The structural equation modeling was used to test the hypotheses.FindingsThe results indicate that considering the budget use with control (diagnostic) characteristics as a mechanism able to elide the benefits of innovation does not find support because no negative effect may be detected in the moderation tests. On the other hand, the belief that budget use with (interactive) planning characteristics might potentiate the effects of innovation on performance has also not been confirmed, i.e. rather flexible budget use types, which could be aligned with the elasticity required by creative processes, do not seem to have the positive effect advocated in the literature.Research limitations/implicationsThe sample did not allow a detailed analysis of other contextual characteristics that could evidence heterogeneity. The size difference between companies, based on the number of employees rather than the volume of innovation investments, may have affected the results.Originality/valueThe results show there is no moderation in the relation between technological innovation and performance, both by using interactive budget and diagnostic budget.
Design orientation in new product development and its measurement
Authors: Cantó Mónica , Frasquet Marta , Irene Gil-Saura 
Published: December 2019

Purpose
The purpose of this paper is to define the design orientation construct, proposing a theoretical framework for its analysis and a validated tool for its measurement.

Design/methodology/approach
The process of scale development follows the recommendations of DeVellis (1991). After qualitative research with experts, quantitative research was performed on a sample of 209 SMEs in the furniture and lighting sectors. The results, based on the use of the confirmatory factor analysis technique, yielded a measurement scale with solid psychometric properties, thus confirming its reliability and validity.

Findings
The resulting scale comprised 19 items grouped into seven dimensions: awareness of the benefits of design, design sensibility, basic design skills, specialized design skills, involving others, design organization and innovation skills.

Practical implications
The instrument can be used to quantify the degree of design orientation in a company, thus enabling cross-sectional and longitudinal diagnoses.

Originality/value
By operationalizing the design orientation construct, this scale serves as a starting point for future developments in the field of business design and design management.
Relieving the regret for maximizers
Authors: Hassan Louise May , Shiu Edward , McGowan Miriam 
Published: December 2019

PurposePrior research consistently found maximizers to experience greater regret over their choice than satisficers. Moreover, research also found maximizers to be trapped in a “maximization-regret-maximization” cycle. This paper aims to assess the role of construal level theory in alleviating regret felt by maximizers.Design/methodology/approachThe authors examine the construal level theory (CLT) in conjunction with the choice context (comparable and non-comparable choices). Three experimental studies tested our assertion that a match between CLT mindset and choice set relieves regret for maximizers.FindingsThe authors show maximizers experience similar levels of regret compared to satisficers when considering comparable options in a concrete mindset, and non-comparable options in an abstract mindset. However, maximizers experience heightened regret in comparison to satisficers when considering non-comparable (comparable) options in a concrete (abstract) mindset. Choice difficulty mediates our effect.Research limitations/implicationsFuture research is needed to replicate our results in real-life settings.Practical implicationsIf marketers think that their product is likely to be compared with other comparable products, they should adopt product-specific information that focusses on how the product would be used. However, if marketers think that consumers will compare across non-comparable products, then they should focus on why their product is the most suitable to fulfil consumers’ needs.Originality/valueThis research represents the first attempt at reducing regret for maximizers and answers the call for an examination of the relationship between maximization and CLT. The research adds to the maximization literature by evidencing a CLT-based strategy that attenuates the negative experience of regret for maximizers.
Establishment and solution of governing equation for plana-grooved liquid seals based on three-control-volume theory
Authors: Zhang Xiumin , Yin Mingfu , Sun Huilai 
Published: December 2019

Purpose
This paper aims to study the dynamic characteristics of the straight-through labyrinth seals, which is applied on an oil sealing belt of hydrostatic support system (HSS) oil pocket, the establishment and solution process of seal governing equation is deduced.

Design/methodology/approach
The three-control-volume model theory is an efficient approach that is applied well. This paper starts with three relative governing equations for the flow characteristics of straight-through labyrinth seals in the plane direction. Referring to the establishment process of governing equations for circumferentially-grooved liquid seals, the governing equation based on space rectangular coordinate system is established, which are transformed into dimensionless equations through a nondimensionalized process and solved by a perturbation method. It contains a zeroth-order equation, through which a steady fluid distribution is determined, and a first-order equation, through which the seal’s dynamic coefficients can be acquired.

Findings
The governing equation for plane-grooved straight-through labyrinth seals can be established and solved by the three-control-volume theory.

Practical implications
This study have important guiding significance for further theoretical research and structural design of the straight-through labyrinth seals on the oil sealing belt of HSS oil pocket.

Originality/value
In this paper, a straight-through labyrinth seal is installed in an oil sealing belt. The three-control-volume governing equations is established in space rectangular coordinate system, and the shear force of the fluid Y-direction is different from the previous model.
An investigation of Indian student attitudes towards entrepreneurs and managers
Authors: Barber III Dennis , Ghouse Suhail Mohammad , Batchelor John , Chaher Francesca , Harris Michael L. , Gibson Shanan G. 
Published: December 2019

PurposeThe purpose of this study was to investigate the perceptions of business students in India toward business managers (not self-employed) and entrepreneurs.Design/methodology/approachStudents’ perceptions of the ethical behaviors of business managers and entrepreneurs were measured using the Bucar and Hisrich (2001) model. The scale comprises 20 behavioral descriptors, and the students were asked to indicate the degree to which they believed entrepreneurs and business managers would consider these actions as ethical.FindingsResponses to general items of ethical behavior demonstrated a difference in the perception of Indian students between business managers and entrepreneurs.Originality/valueThis study contributes to the field of entrepreneurship in two ways. One involves the results of the hypothesis testing presented herein to evaluate the perceptions of business students in India toward entrepreneurs and business managers. The second contribution is comparing these results to that of a similar study using a US sample (Batcheloret al., 2011) to compare the differences in perceptions toward entrepreneurs and business managers across these two nations.
An integrated methodology for supporting the development and the performance evaluation of academic spin-offs
Authors: Iazzolino Gianpaolo , Greco Domenico , Verteramo Saverino , Attanasio Andrea Luca , Carravetta Gilda , Granato Teresa 
Published: December 2019

Purpose
This paper aims to propose an integrated methodology for evaluating academic spin-offs (ASOs) for supporting both the development phase and performance evaluation. The ASOs have peculiar characteristics compared to other start-up companies and the debate on their evaluation is still open.

Design/methodology/approach
The proposed methodology, adopting a lean approach, faces the typical problems that characterize the growth of an ASO: the excessive attention to the technological aspects with respect to the commercial and managerial ones; and the need for evaluation systems that try to evaluate all risk areas and to highlight any misalignment. The methodology was built also starting from the results of an Erasmus + research project, co-funded by the European Commission, called spin-off lean acceleration.

Findings
The methodology proposes to monitor the main risk areas (market, technological, implementation, governance and financial). For each of these areas, at first, a framework and a checklist are proposed for supporting the qualitative assessment of the potential of each areas. In the second part, a set of metrics for monitoring the performances and to understand if the spinoff is developing in the right direction is proposed. Moreover, the methodology was applied to the spin-offs at the University of Calabria (Italy), and the paper reports the first results obtained.

Originality/value
A new canvas model (lean acceleration canvas), more specific and suited to the context of ASOs, was developed and tested. A lean approach has been adopted also for understanding the weakness of traditional methods. The proposed methodology could be used by the technology transfer offices in their institutional activity of supporting ASOs.
A conceptualization of factors affecting collaborative knowledge building in online environments
Authors: Ghazal Samar , Al-Samarraie Hosam , Wright Bianca 
Published: December 2019

Purpose
The purpose of this paper is to address the major findings of published research on the factors influencing students’ knowledge building in an online collaborative environment.

Design/methodology/approach
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses was used to review and synthesize existing empirical studies on knowledge building in a collaborative learning context. In total, 24 studies were identified from major electronic bibliographic databases. The research was conducted between 2017 and 2019. Results of these studies were analyzed to determine potential factors that may influence the knowledge-building process among students.

Findings
Factors related to interaction and participation, task, student and support were found to be the major factors driving students’ knowledge building in the online collaborative learning environment. The association between these factors and certain collaborative tasks was mapped.

Originality/value
Findings from this review can help decision makers of higher education in both developing and developed countries to take the necessary steps in order to promote effective knowledge-building practices in online collaborative learning. It may also help educational policy makers to understand the particulars of collaborative knowledge-building practices, so to increase organizational overall effectiveness and performance.
The role of adenosine A1 receptors in the nucleus accumbens during morphine withdrawal
Authors: Jafarova Demirkapu Mahluga , Yananlı Hasan Raci , Kaleli Melisa , Sakalli Halil Eren , Gören Mehmet Zafer , Topkara Betilay 
Published: December 2019

AbstractOpioids are effective analgaesic agents, but serious adverse effects such as tolerance and withdrawal contribute to opioid dependence and limit their use. Opioid withdrawal is a common occurrence in human opiate addicts that is not life‐threatening. Studies have shown that the mesocorticolimbic system, especially the nucleus accumbens, is an important region in drug addiction and adenosine receptors play a modulatory role in the mechanism of action of drug dependence and withdrawal. The aim of this study was to investigate the effects of the selective A1 receptor agonist CPA (N6‐cyclopentyladenosine) on withdrawal symptoms, and the concentration of dopamine and noradrenaline in the nucleus accumbens and locomotor activity behaviour during naloxone‐precipitated withdrawal in morphine‐dependent rats. The local administration of CPA (1.5, 3.0, and 6.0 mmol/L bilateral 250 nL) into the nucleus accumbens decreased the Gellert–Holtzman withdrawal scale, and increased concentrations of dopamine and noradrenaline in the same region during naloxone‐induced withdrawal. Our findings suggest that administration of the A1 receptor agonist significantly decreased withdrawal behaviours and increased dopamine and noradrenaline concentrations in opioid withdrawal in a dose‐dependent manner. These results demonstrate that adenosine receptors should be examined as a potential mechanism that could be exploited for the treatment of morphine withdrawal.
Maternal characteristics and causes associated with refractory postpartum haemorrhage after vaginal birth: a secondary analysis of the WHO CHAMPION trial data
Authors: Widmer M , Piaggio G , Hofmeyr GJ , Carroli G , Coomarasamy A , Gallos I , Goudar S , Gülmezoglu AM , Lin SL , Lumbiganon P , Mugerwa K , Owa O , Qureshi Z , Althabe F 
Published: December 2019

ObjectiveTo assess the maternal characteristics and causes associated with refractory postpartum haemorrhage (PPH).DesignSecondary analysis of the WHO CHAMPION trial data.SettingTwenty‐three hospitals in ten countries.PopulationWomen from the CHAMPION trial who received uterotonics as first‐line treatment of PPH.MethodsWe assessed the association between sociodemographic, pregnancy and childbirth factors and refractory PPH, and compared the causes of PPH between women with refractory PPH and women responsive to first‐line PPH treatment.Main outcome measuresMaternal characteristics; causes of PPH.ResultsWomen with labour induced or augmented with uterotonics (adjusted odds ratio [aOR] 1.35; 95% CI 1.07–1.72), with episiotomy or tears requiring suturing (aOR 1.82; 95% CI 1.34–2.48) and who had babies with birthweights ≥3500 g (aOR 1.33; 95% CI 1.04–1.69) showed significantly higher odds of refractory PPH compared with the reference categories in the multivariate analysis adjusted by centre and trial arm. While atony was the sole PPH cause in 53.2% (116/218) of the women in the responsive PPH group, it accounted for only 31.5% (45/143) of the causes in the refractory PPH group. Conversely, tears were the sole cause in 12.8% (28/218) and 28% (40/143) of the responsive PPH and refractory PPH groups, respectively. Placental problems were the sole cause in 11 and 5.6% in the responsive and refractory PPH groups, respectively.ConclusionWomen with refractory PPH showed a different pattern of maternal characteristics and PPH causes compared with those with first‐line treatment responsive PPH.Tweetable abstractWomen with refractory postpartum haemorrhage are different from those with first‐line treatment responsive PPH.
A missed opportunity to improve practice around the use of restraints and consent in residential aged care: Limitations of the Quality of Care Amendment (Minimising the Use of Restraints) Principles 2019
Authors: Peisah Carmelle , Jessop Tiffany , Breen Juanita 
Published: December 2019

AbstractObjectiveTo explore the meaning and potential role of new Quality of Care Amendment (Minimising the Use of Restraints) Principles 2019, (Principles) which amend Quality of Care Principles 2014 in improving practice around physical and chemical restraint.MethodsWe examined both Principles and accompanying Explanatory Statement in light of best practices around consent and use of chemical and physical restraint.ResultsThe chemical restraint definition is problematic by exclusion of medications for treating mental disorders, physical illness or physical conditions, which is not considered restraint. Inexplicably, physical restraint requirements are more rigorous than chemical restraint requirements, where assessment is optional, and consent sometimes obtained, after use, and from the person's “representative,” rather than the person first, followed by their proxy decision‐maker.ConclusionsAlthough a start in promoting best practice around physical restraint, the Principles do not address the status quo of poor practice around chemical restraint and may instead codify it.
Primates are an important food resource for leopards (Panthera pardus) in Mahale, Tanzania
Authors: Nakazawa Nobuko 
Published: December 2019

AbstractLeopard diets in the Kasoje area of the Mahale Mountains National Park, Tanzania, were analysed by inspecting prey remains in 256 scats. This area is unique as leopard density is high despite a relatively low density of medium‐sized ungulates, regarded as the most preferred prey of leopards. At least eleven prey mammal species were confirmed in the scats. Small prey mammals up to 10 kg comprised 91.4% of the relative biomass consumed; the mean prey biomass in each scat was 7.6 kg. Blue duiker (31.2%) was the most dominant prey species, followed by the red colobus (29.2%), semi‐terrestrial Cercopithecinae (the vervet monkey and yellow baboon combined) (10.5%) and the red‐tailed monkey (9.9%). At the order level, the most consumed prey taxon was Primates (53.8%), followed by Cetartiodactyla (39.6%) and Rodentia (5.8%). Among primates, the blue monkey was the most preferred prey species, followed by the red colobus and semi‐terrestrial Cercopithecinae. High consumption of primates is a unique characteristic of the leopards in Mahale. This trend exemplifies the flexibility of leopards in their choices of prey, and such flexibility may be one of the underlying reasons for leopards exhibiting the broadest global distribution among all wild felid species.