bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mineralogical and lithological properties of Domanikites from the south-east of Tatarstan Republic
Authors: Khayuzkin A S , Morozov V P , Kolchugin A N , Eskin A A , Eskina G M , Korolev E A , Zakharova N S 
Published: June 2020

Abstract
The article was described main types of rocks – mudstones, carbonate-siliceous rocks, containing organic matter and carbonate breccia, based on detailed analysis of rock samples from Semiluksky horizons of Upper Devonian black shale formations, Volga-Ural region, Russian Federation. Different structures and texture features, mineral composition, and content of organic matter characterized selected types of rocks. Only in the carbonate-siliceous type of rocks is the high content of organic matter, about 9%. It was found direct dependence between the content organic matter and content in rocks silica minerals (quartz and chalcedony). Such dependence caused by joint precipitation silica minerals and accumulation of organic matter in the seafloor in conditions of active seepage of hydrothermal fluids. The presence of an abundance of biophilic elements in ascending fluids led to an explosion of biota and widespread of silica organisms. This hypothesis doesn’t disagree with any authors but considers the significant contribution of fluid factor to the deposition of Semiluksky formations.
Hydrogeological systems of landslides in central part of the Volga-Ural region
Authors: Korolev E A , Eskin A A , Petrova D I , Korolev A E , Barieva E R 
Published: June 2020

Abstract
The study of landslide massifs made it possible to identify two types of hydrogeological systems that differ by feeding area structure and transit zone. In landslide bodies of Urzhuminan stage, composed by dolomites and marls, hydrogeological systems are simple stratal. The aquifers are localized in fractured marls, which, under the influence of infiltration water seeping through them, have turned into a poorly structured gruss-rock cover, which lies on dense dolomites - water-resistant. The inclined bedding of dolomite layers creates the prerequisites for directed filtration of groundwater towards natural lowering. Here forming areas of ground water discharge as low-water springs. In landslides composed of the Upper Jurassic series clays and marls, hydrogeological systems are distinguished by the prevailing vertical groundwater infiltration in transit zone. Theirs’s water source is shallow lakes formed on the surfaces of landslide terraces. Under water pressure influence of in the lake basins and gravity, infiltration groundwaters leaking through the systems of cracks in clays penetrate to a more dense clay layers which are fluid trap. Here, directly under the lake basin, a dome of groundwater is formed. The flow of groundwater from the dome towards inclined depressions leads to creation of unloading areas. They are presented by permanently wet land (flarks) or low-water infiltration springs that come to the surface at the same hypsometric level.
In situ formed carboxylic acids effect on light hydrocarbons oxidation in a carbonate reservoir
Authors: Shageev A , Ganeeva Y , Lukyanov O , Erokhin A , Ziganshina M 
Published: June 2020

Abstract
Enhancing heavy oil recovery is attracting a considerable interest due to the depletion of conventional oil resources. In fact, thermal enhanced oil recovery methods are presenting a potential impact on improving heavy oil recovery especially for terrigenous reservoirs, where they are able to increase oil mobility due to heating (steam and thermal exposure) or due to its in-situ conversion to light fractions during ignition of the reservoir. At the same time, it is worthy to note that steam-thermal methods are accompanied by a significant heat loss when injecting steam into great depths heat. Moreover, oil deposits in heterogeneous low-permeability reservoirs (for example, carbonate) are among the potential unconventional oil resources. Along with geological heterogeneity, low porosity and permeability, fracturing, these reservoirs contain, in most cases, heavy oils with a high content of resins, asphaltenes and hard paraffins, characterized by a non-Newtonian fluid property. All this taken together makes the extraction of oil from such reservoirs a hard task to implement.
Modeling of hydrothermal processes of transformation of super-viscous oil of the Ekaterinovsky deposit in the presence of clay minerals
Authors: Kayukova G , Mikhailova A , Nasyrova Z , Gerasimov A , Ziganshin I , Vandyukova I , Gareev B 
Published: June 2020

Abstract
Using a set of physicochemical methods, the influence of hydrothermal effects on the composition of super-heavy oil of the Ekaterinovsky field in a carbon dioxide medium in the presence of a composition of catalysts - metals of variable valence in model experiments on clay rock-forming minerals was studied. Peculiarities of the transformation of the oil composition associated with the destruction of its high molecular weight components - resins and asphaltenes, and the formation of light saturated and aromatic hydrocarbons are revealed. Changes in the structural-group composition indicate an increase in the aromaticity of the products of the experiments. The greatest changes occur in the composition of resins and asphaltenes, which is reflected in a change in their structural-group composition and their paramagnetic properties. The high sorption ability of the rock to metals included in the composition of the used catalyst composition was revealed.
Modern modifiers for obtaining polymer-bitumen binders
Authors: Khaibullina A , Vagapov B , Galimullin I , Mukhamatdinov I 
Published: June 2020

Abstract
Currently, studying additives to petroleum road bitumen for improving their quality generates a growing interest in research field. Actually, this is related to the requirements for polymer-bitumen materials which are constantly becoming tougher, and therefore the need to develop and produce new polymer-bitumen binders. In this paper we considered the most frequently used effective additives and analyzed their positive and negative sides.
Production of binding materials based on high-viscosity oils and natural bitumens
Authors: Kutlizamaev R , Ivanova I , Popkov A , Tajik A 
Published: June 2020

Abstract
Due to the growing market demand for road bitumen, there is a need to increase the rate of its production. Among the promising technologies currently available, the oxidation of heavy hydrocarbon raw materials with air oxygen is the most optimal technology for producing bituminous binders. In turn, substandard oil reserves are suitable raw materials for this process. Thus, the study of the regularities between the composition of the oxidation products of ultra-viscous oil and the physicochemical properties of the oxidation conditions will contribute to the development of the binding materials production technology.
Using of ethylene-vinyl acetate copolymer for manufacture of road surfaces
Authors: Ivanova I , Kutlizamaev R , Popkov A , Tajik A 
Published: June 2020

Abstract
The trend of European road companies to use an ethylene-vinyl acetate (EVA) copolymer is related to its ability to provide the necessary properties for the road surface, as well as its comparative cheapness and safety. The paper presents a study of bitumen modified by EVA, changes in the physicochemical properties of binders modified by EVA in concentrations from 1 to 10% and the influence of the number of vinyl acetate groups in the polymer composition on the properties of bitumen have been studied. Changes in physicochemical properties of bitumen in dependence on the molecular weight of EVA have been explored, as well as physicomechanical properties of asphalt mixtures with different contents of EVA have been evaluated.
Loss of Taste and Smell as Distinguishing Symptoms of Coronavirus Disease 2019
Authors: Dawson Patrick , Rabold Elizabeth M , Laws Rebecca L , Conners Erin E , Gharpure Radhika , Yin Sherry , Buono Sean A , Dasu Trivikram , Bhattacharyya Sanjib , Westergaard Ryan P , Pray Ian W , Ye Dongni , Nabity Scott A , Tate Jacqueline E , Kirking Hannah L 
Published: June 2020

Abstract
In a household study, loss of taste and/or smell was the fourth most reported symptom (26/42 [62%]) among coronavirus disease 2019 (COVID-19) case patients and had the highest positive predictive value (83% [95% confidence interval [CI], 55%–95%) among household contacts. Olfactory and taste dysfunctions should be considered for COVID-19 case identification and testing prioritization.
1321From high-density mapping to low-density mapping: an approach to delineate the active circuit in complex atrial reentrant tachycardias
Authors: Alonso C , Rodriguez Font E , Guerra Ramos J , Campos Garcia B , Mendez Zurita F , Moreno Weidman Z , Espinosa Viamonte H , Garcia Mancebo S , Mogro J , Gonzalez Matos C , Maldonado Chavez J , Vinolas Prat X 
Published: June 2020

Abstract

Funding Acknowledgements
NA

OnBehalf
NA

Background
High-density activation maps during complex atrial reentrant tachycardias are challenging to interpret as they include the activation patterns of active and passive circuits. Entrainment mapping provides the identification of the active tachycardia circuit. However, current electroanatomic mapping systems are not capable to color-coded the information obtained from entrainment maneuvers.

Objectives
We sought to describe a mapping approach for ablation of complex atrial reentrant tachycardias in which high-density activation maps are transformed into low-density activation maps only displaying the active part of the tachycardia circuit.

Methods
We included consecutive patients with atypical atrial flutter. A high-density activation map was acquired during the index tachycardia. Subsequently, entrainment maneuvers were performed to generate a low-density activation map in which only the activation of the atria directly involved in the flutter circuit was displayed.

Results
Seventeen patients were included 82% male, mean age was 62 ± 7 years. Structural heart disease was present in 59% and 53% had a prior left atrial ablation procedure. Low-density activation maps were successfully generated from an average of 14 ± 3 entrainment points. Twenty circuits (95%) were identified in the left atrium and 1 (5%) in the right atrium. Ablation guided by low-density mapping successfully terminated all ARTs in 267 ± 353 seconds of radiofrequency application.

Conclusion
Low-density mapping based on entrainment maneuvers provides a precise delineation of the active circuit during complex ARTs and resulted in successful arrhythmia termination. This approach can be easily incorporated into clinical practice.
P549CIED infection risk score validation using US health claims data
Authors: Ahmed F Z , Blomstrom Lundqvist C , Bloom H , Cooper C , Ellis C , Goette A , Greenspon A , Love C , Johansen J B , Philippon F , Tarakji K , Holbrook R , Sherfesee L , Xia Y , Krahn A 
Published: June 2020

Abstract

Funding Acknowledgements
This work was supported by Medtronic
Background/Introduction: The increasing number of cardiac implantable electronic device (CIED) infections has led to increased interest in the identification of patients who may benefit from additional infection prevention measures.

Purpose
The purpose of this evaluation was to validate the predictive value of the Prevention of Arrhythmia Device Infection Trial (PADIT) risk score to identify patients at increased risk of CIED infection using a U.S. health claims data set.

Methods
A retrospective analysis using the Optum® Clinformatics® claims database was conducted to create a dataset of index procedures which either did or did not result in an infection. The study population included both commercial and Medicare Advantage patients aged ≥18 years with at least one record of a CIED procedure between January 2011 and September 2014. Major CIED infections, defined as an infection associated with system removal, invasive procedure without system removal, or death attributable to infection, were identified through diagnosis and procedure codes. The dataset was randomized (stratified by PADIT score, which included prior procedures, age, depressed renal function, immunocompromised, and procedure type) into a Development Dataset (60%) and a Validation dataset (40%). A frailty model allowing multiple procedures per patient was fit using the Development Dataset, with PADIT score as the only predictor, excluding patients with prior infection. Prior CIED infection, which was not available in the original PADIT data, was examined for additional predictive value.

Results
The data extraction resulted in a dataset of 53,554 index procedures among 51,583 patients, with 30,950 patients randomized to the Development Dataset. The distribution of procedures was pacemakers (52%), ICD (20%), CRT (12%), and Revision/Upgrade (16%), while prior procedures were none (62%), 1 (37%), and 2 (1%). Among patients with no history of prior CIED infection, the frailty model showed that a 1 unit increase in the PADIT score predicts higher infection risk (20%) in the U.S. claims data set (Table 1). Prior CIED infection was associated with strong additional predictive value (HR 4.77, p &lt; 0.0001) after adjusting for PADIT score.

Conclusion
In the largest external validation of a CIED risk score, the PADIT risk score predicts increased CIED infection risk, identifying higher risk patients that can benefit from targeted interventions to reduce the risk of CIED infection. Prior CIED infection brings additional predictive value to the PADIT score.
P323Triage-HF Plus: identification of heart failure and non-heart failure events in an ambulatory population using remote monitoring and the triage heart failure risk score Algorithm
Authors: Ahmed F , Taylor J , Green C , Wickwar L , Zaidi A , Cunnington C , Motwani M 
Published: June 2020

Abstract

Background/introduction
Previous studies examining the utility of cardiac implantable electronic devices (CIEDs) to remotely monitor heart failure patients for decompensation have not demonstrated an impact on hard end-points. However, a key limitation of these prior studies (REM-HF and MORE-CARE) has been the failure to stratify patients according to their risk of worsening heart failure (WHF) prior to randomization (usual care vs active monitoring). We examined a different approach, using a single manufacturer’s remote monitoring platform, whereby only patients with CIED-derived data indicating the highest risk of WHF are contacted for assessment. The validated ‘Triage Heart Failure Risk Score’ (Triage-HFRS) is a medical algorithm within Medtronic CIEDs that can risk-stratify patients as low-, medium- or high-risk of WHF in the next 30 days based on integrated monitoring of physiological parameters.

Purpose
This study is the largest prospective evaluation of the Triage-HFRS, and examines the additional role of contacting those patients with a ‘High-Risk’ Triage-HFRS alert by telephone (Triage-HF Plus pathway).

Methods
Prospective, real-world evaluation of the Triage-HF Plus pathway undertaken between June 2016 and September 2019. 326 high-risk Triage-HFRS transmissions were contacted for telephone triage assessment. Screening questions were designed to identify episodes of WHF and non-heart failure events. Interventions were at the discretion of the clinical practitioner and in line with guideline-directed practice. An additional 3-month consecutive sample of low and medium Triage-HFRS transmissions (control group) were also contacted for telephone triage assessment (n= 98).

Results
Successful telephone contact was made following 245 high-risk Triage-HFRS alerts. Following contact, 194 (79.1%) patients reported an acute medical issue: 137 (70.6%) reported symptoms consistent with worsening heart failure (WHF) requiring intervention; and 57 (29.4%) had an alternative acute medical problem. 51 (26.2%) had no apparent reason for the high score. The sensitivity and specificity of CIED-based remote monitoring to identify any HF and non-HF events requiring intervention was 99.5% (97.2-99.9%) and 65.5% (57.3-73.2%) respectively; positive predictive value was 79.2%. The negative predictive value of a non-high risk score to rule out an acute event was 98.9%. Overall accuracy of the pathway to identify an acute issue (HF or non-HF related) was 84.8%.

Conclusion
The Triage-HF Plus clinical pathway is a potentially useful remote monitoring tool for patients with heart failure. The pathway has high diagnostic accuracy to identify patients with WHF and a wide range of non-HF issues which are just as relevant in a population who often have multiple complex co-morbidities and are known for their high health care utilisation.
P1061Incidence and location of PVI gaps identified post-cryoballoon ablation for atrial fibrillation
Authors: Eldadah Z , Jons C , Hollis Z , Dekker L , Mathew S , Schmitt J , Gora P , Porterfield C 
Published: June 2020

Abstract

Background
Successful delivery of continuous and durable pulmonary vein isolation (PVI) lesion sets is recognized as being critical to long-term clinical outcomes following ablation for atrial fibrillation (AF). Confirmation of PVI following cryoballoon ablation is commonly achieved using a 3.3F circular mapping catheter (CMC) which can be delivered through the central lumen of the cryoballoon, but other diagnostic tools may be used alone or in conjunction with the 3.3F CMC. A high-density, grid-style mapping catheter is now available in multiple geographies; use in cryoballoon ablation procedures and associated outcomes has not been previously reported.

Purpose
To evaluate diagnostic catheter usage patterns in cryoablation procedures and identify associated trends in procedural characteristics and acute outcomes.

Methods
Self-reported procedural data was prospectively collected in AF cryoablation cases utilizing various diagnostic catheter tools, including the 3.3F CMC and high-density, grid-style mapping catheter (HD Grid). Procedural characteristics and acute outcomes, including the incidence and location of gaps post-ablation, were recorded and analyzed.

Results
Data was collected in 23 cryoablation procedures performed in 7 centers across the United States and Europe. De novo and repeat ablations represented 65.2% and 21.7% of cases, respectively (13.0% not reported). 3D mapping was employed in 95.7% of cases. A left common pulmonary vein was present and ablated in 8.7% (2/23). The 28mm cryoballoon was utilized in all cases, with a single case using both a 23mm and 28mm cryoballoon. The 3.3F CMC was used to confirm isolation in all cases using a variety of techniques: voltage mapping (60.9%), exit block (56.5%), entrance block (30.4%), propagation mapping (4.3%), and activation mapping (4.3%); note: total exceeds 100% as more than one technique may be employed in a single case. In 18 cases, PVI was confirmed using a 3.3F CMC followed by secondary confirmation with HD Grid, enabling a direct comparison of the two technologies. The HD Grid identified a total of 12 gaps in 4 (22.2%) patients, which were missed by the 3.3F CMC (Figure 1). No adenosine or isoproterenol use was documented in any case.
Conclusion(s): The 3.3F CMC is routinely used to confirm PVI following cryoballoon ablation for atrial fibrillation, but it may fail to identify gaps in some patients. Subsequent assessment of PVI using the HD Grid identified residual gaps in nearly a quarter of patients, suggesting that sensitivity for gap detection may be improved with this tool. Limitations of this analysis include the small sample size and workflows which consistently assessed PVI with the high-density mapping catheter after confirming isolation with the 3.3F CMC. Despite these limitations, the incidence of residual gaps observed is noteworthy and may warrant additional study.
Abstract Figure.
P338Dystrophin deficient cardiomyopathy: predictors associated with the cardiac phenotype in a Duchenne registry population - A guide for device therapy
Authors: Carron J , Fitzgerald S J , Costello R , Sheahan R 
Published: June 2020

Abstract

Background
Patients with Duchenne muscular dystrophy (DMD) typically exhibit cardiac dysfunction. With increasing life expectancy due to advances in respiratory support, cardiomyopathy and associated dsyrhythmia are fast becoming the primary cause of morbidity and mortality in this patient group. Despite advances, the correlation between genotype and cardiac phenotype remains poorly understood and individual registries small, with implementation of device therapy often delayed due to poor diagnostic imaging.
Methods and Aims: A single-center registry for DMD patients was established and data including genotyping, medical therapy and investigations such as cardiac MRI, nt-Pro BNP levels, echocardiogram were analysed. The aim was to potentially identify predictors associated with a more severe cardiac phenotype and thus help to guide provision of device therapy.

Results
A total of 19 patients (age 17 - 31) with DMD were reviewed (demographics table 1). All patients were evaluated with echocardiography on at least one occasion (mean EF 46.5%). Cardiac MRI was attempted in 6 patients however only completed in 2 due to contractures preventing access to scanning. 11 of 19 patients (58%) demonstrated an impaired left ventricular ejection fraction (EF) &lt;50% (mean EF 42%). Proximal "hot spot" mutations/deletions (exon 2-19) were associated with a more pronounced reduction in EF, all patients with proximal mutations demonstrating an EF &lt; 45% (mean 41%). 5 of 6 (83%) of those with &gt;1 exon deletion mutations demonstrated more severely impaired EF (mean EF 41%) compared to those with single exon deletions (mean EF 52%). Interestingly, one patient with a proximal mutation (exon 3-6 deletion) remains mobilising to distances of 70 meters, however cardiac MRI revealed a moderate degree of fibrosis with an EF of 43%. Correlation between nt-Pro BNP levels with reduced EF was not uniform, however a level &lt; 100 was associated with an EF &gt;55% in 89% of patients studied. of those on steroid regimes, 6 (54%) had impaired LVEF compared to 5 (83%) of those not on steroid therapy. All patients were on at least one class of heart failure modification, with 79% on two and 37% on three agents. Only one patient in the registry has had an ICD implanted. He has had a device for 10 years in and in this time there have been no therapies delivered however runs of non-sustained ventricular tachycardia have been noted.

Conclusions
Correlation between predictors and cardiac phenotype in a Duchenne population remains unreliable. Location and size of exon alteration appears to be indicative of more markedly impaired LV function, however larger studies are required to characterise this further and challenges remain with regard to accurate assessment of EF. The use of predictors in future may help to guide appropriate provision of device therapy.