bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between physiological responses after exercise at low altitude and acute mountain sickness upon ascent is sex-dependent
Authors: Shen Yang , Yang Yuan-Qi , Liu Chuan , Yang Jie , Zhang Ji-Hang , Jin Jun , Tan Hu , Yuan Fang-Zheng-Yuan , Ke Jing-Bin , He Chun-Yan , Zhang Lai-Ping , Zhang Chen , Yu Jie , Huang Lan 
Published: November 2020

Abstract

Background
Acute mountain sickness (AMS) is the mildest form of acute altitude illnesses, and consists of non-specific symptoms when unacclimatized persons ascend to elevation of ≥2500 m. Risk factors of AMS include: the altitude, individual susceptibility, ascending rate and degree of pre-acclimatization. In the current study, we examined whether physiological response at low altitude could predict the development of AMS.

Methods
A total of 111 healthy adult healthy volunteers participated in this trial; and 99 (67 men and 32 women) completed the entire study protocol. Subjects were asked to complete a 9-min exercise program using a mechanically braked bicycle ergometer at low altitude (500 m). Heart rate, blood pressure (BP) and pulse oxygen saturation (SpO2) were recorded prior to and during the last minute of exercise. The ascent from 500 m to 4100 m was completed in 2 days. AMS was defined as ≥3 points in a 4-item Lake Louise Score, with at least one point from headache wat 6–8 h after the ascent.

Results
Among the 99 assessable subjects, 47 (23 men and 24 women) developed AMS at 4100 m. In comparison to the subjects without AMS, those who developed AMS had lower proportion of men (48.9% vs. 84.6%, P < 0.001), height (168.4 ± 5.9 vs. 171.3 ± 6.1 cm, P = 0.019), weight (62.0 ± 10.0 vs. 66.7 ± 8.6 kg, P = 0.014) and proportion of smokers (23.4% vs. 51.9%, P = 0.004). Multivariate regression analysis revealed the following independent risks for AMS: female sex (odds ratio (OR) =6.32, P < 0.001), SpO2 change upon exercise at low altitude (OR = 0.63, P = 0.002) and systolic BP change after the ascent (OR = 0.96, P = 0.029). Women had larger reduction in SpO2 after the ascent, higher AMS percentage and absolute AMS score. Larger reduction of SpO2 after exercise was associated with both AMS incidence (P = 0.001) and AMS score (P < 0.001) in men but not in women.

Conclusions
Larger SpO2 reduction after exercise at low altitude was an independent risk for AMS upon ascent. Such an association was more robust in men than in women.

Trial registration
Chinese Clinical Trial Registration, ChiCTR1900025728. Registered 6 September 2019.
Evaluating the effectiveness of a multi-faceted inpatient diabetes management program among hospitalised patients with diabetes mellitus
Authors: Kao Shih Ling , Chen Ying , Ning Yilin , Tan Maudrene , Salloway Mark , Khoo Eric Yin Hao , Tai E Shyong , Tan Chuen Seng 
Published: November 2020

Abstract

Background
Diabetes mellitus (DM) is one of the most common chronic diseases. Individuals with DM are more likely to be hospitalised and stay longer than those without DM. Inpatient hypoglycemia and hyperglycemia, which are associated with adverse outcomes, are common, but can be prevented through hospital quality improvement programs.

Methods
We designed a multi-faceted intervention program with the aim of reducing inpatient hypoglycemia and hyperglycemia. This was implemented over seven phases between September 2013 to January 2016, and covered all the non-critical care wards in a tertiary hospital. The program represented a pragmatic approach that leveraged on existing resources and infrastructure within the hospital. We calculated glucometric outcomes in June to August 2016 and compared them with those in June to August 2013 to assess the overall effectiveness of the program. We used regression models with generalised estimating equations to adjust for potential confounders and account for correlations of repeated outcomes within patients and admissions.

Results
We observed significant reductions in patient-days affected by hypoglycemia (any glucose reading < 4 mmol/L: OR = 0.71, 95% CI: 0.61 to 0.83, p <  0.001), and hyperglycemia (any glucose reading > 14 mmol/L: OR = 0.84, 95% CI: 0.71 to 0.99, p = 0.041). Similar findings were observed for admission-level hypoglycemia and hyperglycemia. Further analyses suggested that these reductions started to occur four to 6 months post-implementation.

Conclusions
Our program was associated with sustained improvements in clinically relevant outcomes. Our described intervention could be feasibly implemented by other secondary and tertiary care hospitals by leveraging on existing infrastructure and work force.
Functional evaluation of gene mutations in Long QT Syndrome: strength of evidence from in vitro assays for deciphering variants of uncertain significance
Authors: Hancox Jules C. , Stuart Alan G. , Harmer Stephen C. 
Published: November 2020

AbstractBackgroundGenetic screening is now commonplace for patients suspected of having inherited cardiac conditions. Variants of uncertain significance (VUS) in disease-associated genes pose problems for the diagnostician and reliable methods for evaluating VUS function are required. Although function is difficult to interrogate for some genes, heritable channelopathies have established mechanisms that should be amenable to well-validated evaluation techniques.The cellular electrophysiology techniques of ‘voltage-’ and ‘patch-’ clamp have a long history of successful use and have been central to identifying both the roles of genes involved in different forms of congenital Long QT Syndrome (LQTS) and the mechanisms by which mutations lead to aberrant ion channel function underlying clinical phenotypes. This is particularly evident forKCNQ1,KCNH2andSCN5A, mutations in which underlie > 90% of genotyped LQTS cases (the LQT1-LQT3 subtypes). Recent studies utilizing high throughput (HT) planar patch-clamp recording have shown it to discriminate effectively between rare benign and pathological variants, studied through heterologous expression of recombinant channels. In combination with biochemical methods for evaluating channel trafficking and supported by biophysical modelling, patch clamp also provides detailed mechanistic insight into the functional consequences of identified mutations. Whilst potentially powerful, patient-specific stem-cell derived cardiomyocytes and genetically modified animal models are currently not well-suited to high throughput VUS study.ConclusionThe widely adopted 2015 American College of Medical Genetics (ACMG) and Association for Molecular Pathology (AMP) guidelines for the interpretation of sequence variants include the PS3 criterion for consideration of evidence from well-established in vitro or in vivo assays. The wealth of information on underlying mechanisms of LQT1-LQT3 and recent HT patch clamp data support consideration of patch clamp data together (for LQT1 and LQT2) with information from biochemical trafficking assays as meeting the PS3 criterion of well established assays, able to provide ‘strong’ evidence for functional pathogenicity of identified VUS.
Human reliability analysis of bronchoscope-assisted percutaneous dilatational tracheostomy: implications for simulation-based education
Authors: Lavelle Aoife , White Mary , Griffiths Mark J.D. , Byrne Dara , O’Connor Paul 
Published: November 2020

AbstractBackgroundTeaching and assessing clinical procedures requires a clear delineation of the individual steps required to successfully complete the procedure. For decades, human reliability analysis (HRA) has been used to identify the steps required to complete technical procedures in higher risk industries. However, the use of HRA is uncommon in healthcare. HRA has great potential supporting simulation-based education (SBE) in two ways: (1) to support training through the identification of the steps required to complete a clinical procedure; and (2) to support assessment by providing a framework for evaluating performance of a clinical procedure. The goal of this study was to use HRA to identify the steps (and the risk associated with each of these steps) required to complete a bronchoscope-assisted percutaneous dilatational tracheostomy (BPDT). BPDT is a potentially high-risk minimally invasive procedure used to facilitate tracheostomy placement at the bedside or in the operating theatre.MethodsThe subgoals, or steps, required to complete the BPDT procedure were identified using hierarchical task analysis. The Systematic Human Error Reduction and Prediction Approach (SHERPA) was then used to identify potential human errors at each subgoal, the level of risk and how these potential errors could be prevented.ResultsThe BPDT procedure was broken down into 395 subgoals, of which 18% were determined to be of high-risk. The most commonly identified remediation strategies for reducing the risk of the procedure included: checklist implementation and audit, statutory and mandatory training modules, simulation training, consultant involvement in all procedures, and fostering a safety-focused hospital culture.ConclusionThis study provides an approach for how to systematically identify the steps required to complete a clinical procedure for both training and assessment. An understanding of these steps is the foundation of SBE. HRA can identify ‘a correct way’ for teaching learners how to complete a technical procedure, and support teachers to give systematic and structured feedback on performance.
Automated, cassette-based isolation and formulation of high-purity [61Cu]CuCl2 from solid Ni targets
Authors: Svedjehed Johan , Kutyreff Christopher J. , Engle Jonathan W. , Gagnon Katherine 
Published: November 2020

Abstract

Background
A need for improved, cassette-based automation of 61Cu separation from irradiated Ni targets was identified given the growing interest in theranostics, and generally lengthy separation chemistries for 64Cu/64Ni, upon which 61Cu chemistry is often based.

Methods
A method for separating 61Cu from irradiated natNi targets was therefore developed, with provision for target recycling. Following deuteron irradiation, electroplated natNi targets were remotely transferred from the cyclotron and dissolved in acid. The dissolved target solution was then transferred to an automated FASTlab chemistry module, where sequential TBP and TK201 (Triskem) resins isolated the [61Cu]CuCl2, removed Ni, Co, and Fe, and concentrated the product into a formulation suitable for anticipated radiolabelling reactions.

Results
61Cu saturation yields of 190 ± 33 MBq/μA from energetically thick natNi targets were measured. The average, decay-corrected, activity-based dissolution efficiency was 97.5 ± 1.4% with an average radiochemical yield of 90.4 ± 3.2% (N = 5). The isolated activity was collected approximately 65 min post end of bombardment in ~ 2 mL of 0.06 M HCl (HCl concentration was verified by titration). Quality control of the isolated [61Cu]CuCl2 (N = 5) measured 58Co content of (8.3 ± 0.6) × 10− 5% vs. 61Cu by activity, Ni separation factors ≥ (2.2 ± 1.8) × 106, EoB molar activities 85 ± 23 GBq/μmol and NOTA-based EoB apparent molar activities of 31 ± 8 MBq/nmol and 201 MBq/nmol for the 30 min and 3.3 h (N = 1) irradiations, respectively.

Conclusion
High purity 61Cu was produced with the developed automated method using a single-use, cassette-based approach. It was also applicable for 64Cu, as demonstrated with a single proof-of-concept 64Ni target production run.
Adapting implementation science for higher education research: the systematic study of implementing evidence-based practices in college classrooms
Authors: Soicher Raechel N. , Becker-Blease Kathryn A. , Bostwick Keiko C. P. 
Published: November 2020

Abstract
Finding better ways to implement effective teaching and learning strategies in higher education is urgently needed to help address student outcomes such as retention rates, graduation rates, and learning. Psychologists contribute to the science and art of teaching and learning in higher education under many flags, including cognitive psychology, science of learning, educational psychology, scholarship of teaching and learning in psychology, discipline-based educational research in psychology, design-based implementation research, and learning sciences. Productive, rigorous collaboration among researchers and instructors helps. However, translational research and practice-based research alone have not closed the translation gap between the research laboratory and the college classroom. Fortunately, scientists and university faculty can draw on the insights of decades of research on the analogous science-to-practice gap in medicine and public health. Health researchers now add to their toolbox of translational and practice-based research the systematic study of the process of implementation in real work settings directly. In this article, we define implementation science for cognitive psychologists as well as educational psychologists, learning scientists, and others with an interest in use-inspired basic cognitive research, propose a novel model incorporating implementation science for translating cognitive science to classroom practice in higher education, and provide concrete recommendations for how use-inspired basic cognitive science researchers can better understand those factors that affect the uptake of their work with implementation science.
An initial accuracy focus reduces the effect of prior exposure on perceived accuracy of news headlines
Authors: Calvillo Dustin P. , Smelter Thomas J. 
Published: November 2020

AbstractThe illusory truth effect occurs when the repetition of a claim increases its perceived truth. Previous studies have demonstrated the illusory truth effect with true and false news headlines. The present study examined the effects that different ratings made during initial exposure have on the illusory truth effect with news headlines. In two experiments, participants (totalN = 575) rated a set of news headlines in one of two conditions. Some participants rated how interesting they were, and others rated how truthful they were. Participants later rated the perceived accuracy of a larger set of headlines that included previously rated and new headlines. In both experiments, prior exposure increased perceived accuracy for participants who made initial interest ratings, but not for participants who made initial truthfulness ratings. The increase in perceived accuracy that accompanies repeated exposure was attenuated when participants considered the accuracy of the headlines at initial exposure. Experiment 2 also found evidence for a political bias: participants rated politically concordant headlines as more accurate than politically discordant headlines. The magnitude of this bias was related to performance on a cognitive reflection test; more analytic participants demonstrated greater political bias. These results highlight challenges that fake news presents and suggest that initially encoding headlines’ perceived truth can serve to combat the illusion that a familiar headline is a truthful one.
Evaluation of the safety and efficacy of beta blockers in septic patients: a randomized control trial
Authors: Gadallah Raouf Ramzy , Aboseif Eman Mohamed Kamal , Ibrahim Dalia Ahmed , Zaki Hany Victor , Abdelmaksoud Mohamed Nabil Mohamed 
Published: November 2020

Abstract

Background
Sepsis is a common fatal complication of an infection. As part of the host response, sympathetic stimulation can result in many serious complications such as septic myocardial depression and metabolic, hematological, and immunological dysfunction. Treatment with beta blockers may reduce this pathophysiological response to infection, but the clinical outcomes are not clear.

Results
Our study showed a significant difference as regards decrease in heart rate in group B with P value < 0.001 compared to group A, besides a reduction in 28-day mortality (P value 0.0385) and ICU stay (P value < 0.001) in group B compared to group A.

Conclusion
This study supports the role of intravenous beta blockers in sepsis patients by decreasing heart rate without affecting the hemodynamics, in addition to decreasing 28-day mortality and ICU stay.
The role of optical coherence tomography guidance in scaffold versus stent optimization
Authors: Al Nooryani Arif A. , Abdelrahman Nagwa A. , Helmy Hatem A. , Kishk Yehia T. , Hassan Ayman K. M. 
Published: November 2020

Abstract

Background
Optical coherence tomography showed a great ability to identify adverse features during percutaneous coronary intervention with drug-eluting stents and resulted in better clinical outcomes. The study aimed to assess the impact of optical coherence tomography on intraoperative decision-making during implantation of Absorb bioresorbable scaffolds versus everolimus drug-eluting stents.

Results
We performed an observational study that included 223 consecutive patients post optical coherence tomography-guided implantation of either Absorb bioresorbable scaffolds (162 patients) or everolimus drug-eluting stents (61 patients). We studied the influence of optical coherence tomography on intraoperative decision-making during implantation of bioresorbable scaffolds versus drug-eluting stents by analyzing the total rate of optical coherence tomography-dependent modifications in each device.
After satisfactory angiographic results, the total rate of required intervention for optical coherence tomography detected complications was significantly higher in the bioresorbable scaffolds arm compared to drug-eluting stents arm (47.8% versus 32.9%, respectively; p = 0.019). The additional modifications encompassed further optimization in the case of device underexpansion or struts malapposition, and even stenting in the case of strut fractures, or significant edge dissection.

Conclusions
Compared to drug-eluting stents, Absord scaffold was associated with a significantly higher rate of optical coherence tomography-identified intraprocedural complications necessitating further modifications. The study provides some hints on the reasons of scaffolds failure in current PCI practice; it offers a new insight for the enhancement of BRS safety and presents and adds to the growing literature for successful BRS utilization.
Fetal magnetic resonance imaging in the evaluation of congenital diaphragmatic anomalies
Authors: Mahalingam Harshavardhan , Babu Biji , Rangasami Rajeswaran , Suresh Sudarshan , Suresh Indrani , Andrew Chitra 
Published: November 2020

AbstractBackgroundCongenital abnormalities of the diaphragm cause impairment of lung development and are an important cause of post-natal morbidity and mortality. Congenital diaphragmatic eventration (CDE), a less sinister diaphragmatic anomaly compared to the more common congenital diaphragmatic hernia (CDH), often tends to mimic CDH on prenatal imaging. This study evaluates the role of fetal magnetic resonance imaging (MRI) in differentiating these two entities.ResultsThis was a retrospective study which included fetal MRI studies done in patients with ultrasound diagnosis of fetal diaphragmatic anomaly. MRI exam was performed with a 1.5 T superconducting system with eight-element torso array coil. The images were studied by two radiologists experienced in fetal imaging in consensus. Diagnosis of CDE was made if the dome of the diaphragm was visualized as a thin hypointense line separating the lung from abdominal structures on coronal and sagittal MRI sequences. If this thin hypointense line was not visualized, a diagnosis of CDH was made. The findings were then correlated with autopsy/intra-operative findings/post-natal imaging follow-up. A total of 12 patients were included in the study. In these 12 patients, 13 diaphragmatic abnormalities were diagnosed on MRI (1 fetus had bilateral diaphragmatic anomaly). Of the 13 diaphragmatic anomalies detected, 7 (54%) were CDH and 6 (46%) were CDE. The type of diaphragmatic anomaly was correctly identified on MRI in all except one fetus in which CDE was misdiagnosed as CDH. The Fisher exact test statistic value was 0.0047. The result was significant atp< 0.01.ConclusionFetal MRI is a useful tool for assessing congenital diaphragmatic anomalies. Visualization of the diaphragm on coronal and sagittal images helps in diagnosis of complete CDE and differentiating it from the more sinister CDH.
The Political Aesthetics of Vulnerability and the Feminist Revolt
Authors: Sabsay Leticia 
Published: November 2020

AbstractContemporary transnational times are characterized by renewed struggles over the meaning of democracy. In this postdemocratic moment, political and cultural practices and popular mobilizations and demands have exceeded, and ultimately questioned, some of representative democracy's core conventions, from the mass feminist demonstrations and strikes, to the rise of populist politics both in Europe and the Americas. Importantly, these struggles attest to the tension between failing democratic institutions and the heightening of increasingly authoritarian and cruel forms of social precarization and exclusion. Against these murderous trends, which this article characterizes as marked by an aesthetics of cruelty, some of these struggles foreground the vulnerable character of life and the embodied dimension of politics and its affective domains. This article focuses on the social movement Ni Una Menos to examine the ways in which vulnerability has been mobilized by some contemporary feminist popular struggles, focusing on the current investment in cultural activism opposing the curtailment of bodily life along gendered, sexualized, and racialized lines. Ultimately, this intervention seeks to ponder the emancipatory potential of a political aesthetics that weaves vulnerability into the gendering of democratic claims.
At Odds with the Temporalities of the Im-possible; or, What Critical Theory Can (Still) Do
Authors: Athanasiou Athena 
Published: November 2020

Abstract
This essay engages with the question of critical possibility—or, the possibility of critique—and, more specifically, the political temporalities that sustain critical potential in the present and for the future. The essay asks whether and how the aesthetic can serve as a resource for making sense of the question of possibility and for developing a conception of critical subjectivity. To question what critical theory might still do in the present treats critique as an experience of the im-possible, and yet as a transformative force for shifting the conditions of possibility for knowledge production. In this way, this essay seeks to address the aporetic elements in the utopian thinking of critical theory.
Analysis of the Interaction between a Protein and Polymer Membranes Using Steered Molecular Dynamics Simulation to Interpret the Fouling Behavior
Authors: Mieda Shunsuke 
Published: November 2020

Abstract
In this study, I aimed to interpret fouling phenomena by calculating water mobility and absorption free energy of four types of polymer membranes. Although water mobility could partially represent the experimental interaction forces, it was difficult to estimate the fouling phenomena using only this index. However, the free energies computed using steered molecular dynamic simulations could estimate the experimental results quantitatively. In addition to the interaction energies, detailed interaction analyses of protein desorption from the polymer membrane were required to predict protein absorption. The series of computational analyses undertaken here would serve as a handy tool to predict the fouling ability of proteins and polymer membranes.