bluuebunny/crossref_metadata_2025_split huggingface dataset:
Organizational learning culture and business intelligence systems of health-care organizations in an emerging economy
Authors: Arefin Md. Shamsul , Hoque Md. Rakibul , Rasul Tareq 
Published: September 2020

PurposeThis paper aims to investigate the role of business intelligence systems (BIS) in the relationship between organizational learning culture and organizational performance in the health-care context.Design/methodology/approachA quantitative approach was applied to identify the hypothesized relationships. Data were obtained from a survey of 217 mid- and top-level managers of health-care organizations in Bangladesh. Structural equation modeling was used to analyze the data.FindingsThe findings attest to the effectiveness of the mediating role of BIS in the relationship between organizational learning culture and organizational performance within health-care organizations. The theoretical and practical implications of the findings are also discussed.Research limitations/implicationsThe study data were collected from a single country, which made generalization difficult. Further research should be carried out to replicate the present study with different organizational cultural variables and organizational outcomes, such as patient satisfaction.Practical implicationsThis study provides a clear direction for hospital managers to invest more resources in an effective learning culture, to be positively mediated by BIS and to eventually enhance their hospitals’ performance. In addition, this study also suggests that hospital managers should focus on building a knowledge-based learning culture, to effectively use the information provided by BIS.Originality/valueDespite the prior study on the applications of BIS and their value to an organization, little is known about the impact of organizational learning culture on BIS in health-care organizations. The findings give support to the argument that organizational learning culture plays an important role in BIS that, in turn, affects business performance.
How management control systems enable and constrain integrated thinking
Authors: Dimes Ruth , de Villiers Charl 
Published: September 2020

PurposeThis paper aims to examine how management control systems (MCS) can enable and constrain the successful adoption of integrated thinking in an organisation.Design/methodology/approachThe study adopts a case study approach, involving in-depth interviews and documentary evidence.FindingsThe case study organisation perceived trust to be critical to the successful adoption of integrated thinking, and informal social controls with strong endorsement from senior management frequently substituted for more formal technical controls in helping to develop a trust-based organisational culture. These cultural changes improved collaboration and brought economic benefits by encouraging outcome-based decision-making rather than capital-based decision-making, thereby enabling employees to identify and address poorly performing projects earlier. However, established performance measurement systems geared towards reporting and rewarding accounting profits created tension, constraining the potential benefits of integrated thinking by reinforcing business unit protectionism.Practical implicationsIntegrated thinking can be seen as a form of management with the potential to improve organisational outcomes. An improved understanding of factors that might enable or constrain integrated thinking could facilitate its spread.Originality/valueDespite several calls for research on the practical implementation of integrated thinking, this has not been studied extensively. To the best of the authors’ knowledge, this study is one of the firsts to contribute to a better understanding of the role of MCS in the successful implementation of integrated thinking in an organisation. The study also contributes to the MCS literature.
The effect of vibratory conditioning on tensile strength and microstructure of 1018 mild steel
Authors: Bade Venkata Suresh , P. Srinivasa Rao , P. Govinda Rao 
Published: September 2020

PurposeThe purpose of this paper is to investigate the prominence of mechanical excitations at the time of welding. In the past years, the process of welding technology has expanded its influence in manufacturing. The crucial drawback of conventional welding is prompted by internal stresses and distortions, which is the focal reason for weld defects. These weld defects can be diminished by the process called post-weld heat treatment (PWHT), which consumes more working hours and needs skilled workers. To replace these PWHT processes, mechanical vibrations are introduced during the process of welding to diminish these weld defects.Design/methodology/approachIn the current research, the mechanical vibrations are transferred to weld-pool through vibro-motor and DC motor connected to the electrode. As per standards, the tensile test specimens were prepared for welding with different voltages of vibro-motor and DC motor respectively. The weld joints were tested for tensile strength and analyzed the microstructure at the fusion zone.FindingsMelt-ability at fusion zone of 1018 mild steel was investigated by the single-stroke intense heat process of fusion welding. It is observed that the mechanical vibrations technique has a profound influence on the enhancement of the fusion zone characteristics and grain structure. The peak value of the tensile strength is observed at 100 s of vibration, 190 V of vibro-motor voltage and 18 V of electrode voltage. The tensile strength of the welded joints with vibrations is increased up to 22.64% when it is compared with conventional welding. The enhancement of the tensile strength of the weld bead was obtained because of the formation of fine grain structure. So, mechanical vibrations are identified as the most convenient method for improving the mild steel alloys weld quality.Originality/valueA novel approach called mechanical vibrations during the process of welding is implemented for fusion zone refinement.
Syn-collisional magmatic record of Indian steep subduction by 50 Ma
Authors: Qi Yue , Hawkesworth Chris J. , Wang Qiang , Wyman Derek A. , Li Zheng-Xiang , Dong Han , Ma Tao , Chen Fukun , Hu Wan-Long , Zhang Xiu-Zheng 
Published: September 2020

Abstract
Subduction of Indian continental lithosphere during the Asia-India collision played an important role in the formation and evolution of the Himalaya-Tibetan orogen. However, the geometry of early Indian continental subduction remains debated. Given that the Indian continent is characterized by enriched isotope ratios (87Sr/86Sr &gt; 0.730, εNd(t) &lt; −10), relative to those in subducted oceanic materials (87Sr/86Sr &lt; 0.704, εNd(t) ≈ +8), changes in the composition of magmatic rocks with time, in particular their radiogenic isotope ratios, is used to constrain the timing and nature of continental subduction. This study reports the field relations, zircon U-Pb ages and geochemical composition of a syn-collisional batholith that crosscuts the central Indus-Yarlung Zangbu suture in the Saga area of southern Tibet. Zircon U/Pb ages for the batholith mainly range from 50 to 46 Ma. Samples from the Lopu Range batholith have enriched zircon Hf (εHf(t) = −0.4 to −8.6) and whole rock 87Sr/86Sri = 0.7094–0.7121 and εNd(t) = −7.3 to −9.8, suggesting that they were derived from a mixture of juvenile Gangdese and isotopically enriched Indian crustal materials. This result indicates that subduction of Indian crustal rocks occurred before 50 Ma in the central Himalaya. The geochemical composition and distribution of high volume ca. 51 Ma magmatism in the Gangdese belt, combined with thermal models of the subduction zone, suggests a steepening of the subducted Indian continental lithosphere occurred between the onset of India-Asia collision (59 Ma) and 46 Ma in the central-eastern Himalaya.
Cost-effectiveness of surveillance with CT colonography after resection of colorectal cancer
Authors: Kuntz Karen M , Popp Jonah , Beck J Robert , Zauber Ann G , Weinberg David S 
Published: September 2020

ObjectiveSurveillance following colorectal cancer (CRC) resection uses optical colonoscopy (OC) to detect intraluminal disease and CT to detect extracolonic recurrence. CT colonography (CTC) might be an efficient use of resources in this situation because it allows for intraluminal and extraluminal evaluations with one test.DesignWe developed a simulation model to compare lifetime costs and benefits for a cohort of patients with resected CRC. Standard of care involved annual CT for 3 years and OC for years 1, 4 and every 5 years thereafter. For the CTC-based strategy, we replace CT+OC at year 1 with CTC. Patients with lesions greater than 6 mm detected by CTC underwent OC. Detection of an adenoma 10 mm or larger was followed by OC at 1 year, then every 3 years thereafter. Test characteristics and costs for CTC were derived from a clinical study. Medicare costs were used for cancer care costs as well as alternative test costs. We discounted costs and effects at 3% per year.ResultsFor persons with resected stage III CRC, the standard-of-care strategy was more costly (US$293) and effective (2.6 averted CRC cases and 1.1 averted cancer deaths per 1000) than the CTC-based strategy, with an incremental cost-effectiveness ratio of US$55 500 per quality-adjusted life-year gained. Our analysis was most sensitive to the sensitivity of CTC for detecting polyps 10 mm or larger and assumptions about disease progression.ConclusionIn a simulation model, we found that replacing the standard-of-care approach to postdiagnostic surveillance with a CTC-based strategy is not an efficient use of resources in most situations.
Screening for monoclonal B-lymphocyte expansion in a hospital-based Chinese population with lymphocytosis: an observational cohort study
Authors: Xu Jiadai , Li Jing , Wei Zheng , Wang Yue , Liu Peng 
Published: September 2020

ObjectivesScreening of monoclonal B-cell lymphocytosis (MBL) has improved the early detection of B-cell lymphoproliferative disorders (B-LPDs). This study was designed to find the most cost-effective way to screen for asymptomatic B-LPD.DesignObservational study.SettingA lymphocytosis screening project was conducted at a large-scale hospital among the Chinese population.ParticipantsFor 10 consecutive working days in 2018, 22 809 adult patients who received a complete blood count (CBC) were reviewed. These patients were selected from the outpatient, inpatient and health examination departments of a National Medical Centre in China.ResultsA total of 254 patients (1.1%, 254/22 809) were found to have lymphocytosis (absolute lymphocyte count (ALC) >3.5×109/L). Among them, a population of circulating monoclonal B-lymphocytes were detected in 14 patients, with 4 having chronic lymphocytic leukaemia (CLL) and 10 having MBL, indicating an overall prevalence of 5.5% for B-LPD (3.9% for MBL). The prevalence of CLL among the elderly patients with lymphocytosis (≥60 years) was determined to be 4.3% (4/92). In the patients over 60 years of age, the prevalence of MBL was found to be 8.7%. CD5 (−) non-CLL-like MBL was observed to be the most common subtype (8, 80%), followed by CLL-like phenotype (1, 10.0%) and atypical CLL phenotype (1, 10.0%). The receiver operating characteristic curve analysis for the CBC results revealed that the ALC of 4.7×109/L may serve as the optimal and cost-effective cut-off for screening for early-stage asymptomatic B-LPD.ConclusionIn Chinese patients with lymphocytosis, there was a relatively high proportion of patients with CLL among individuals over 60 years of age. MBL is an age-related disorder. Non-CLL-like MBL was the most common MBL subtype, almost all of whom displayed a pattern of ‘marginal zone lymphoma (MZL)-like’ MBL. Lymphocytosis screening among the elderly would be effective in the detection of B-LPD and MBL.
Climate and size of previous cone crops contribute to large-scale synchronous cone production in balsam fir
Authors: Bouchard Mathieu , Pernot Clémentine 
Published: September 2020

Mast year occurrence in trees is often synchronized across large regions. In this study, we used dendrochronological methods based on cone scar characteristics on tree branches in order to reconstruct male and female cone production in balsam fir (Abies balsamea (L.) Mill.) during the period 1988–2018. Results indicate that mast years generally occur every second year and can be synchronized across distances >1000 km. The main predictors of current-year cone abundance were cone abundance during the two previous years, which can be considered a proxy for resource availability for cone bud development during the current year, together with relatively warm temperature during cone bud development. Presence of aborted male cones was positively correlated with the occurrence of relatively cold episodes during cone bud development. This finding suggests that the influence of weather on cone crop abundance is at least partly mediated by growth cessation in the developing cone buds. We also suggest that a change in weather patterns before and after the 2005–2010 period is responsible for a switch in mast years from even to uneven calendar years around that time.
Data driven flavour model
Authors: Arias-Aragón F. , Bouthelier-Madre C. , Cano J. M. , Merlo L. 
Published: September 2020

AbstractA bottom-up approach has been adopted to identify a flavour model that agrees with present experimental measurements. The charged fermion mass hierarchies suggest that only the top Yukawa term should be present at the renormalisable level. Similarly, describing the lightness of the active neutrinos through the type-I Seesaw mechanism, right-handed neutrino mass terms should also be present at the renormalisable level. The flavour symmetry of the Lagrangian including the fermionic kinetic terms and only the top Yukawa is then a combination of U(2) and U(3) factors. Once considering the Majorana neutrino terms, the associated symmetry is O(3). Lighter charged fermion and active neutrino masses and quark and lepton mixings arise considering specific spurion fields à la Minimal Flavour Violation. The associated phenomenology is investigated and the model turns out to have almost the same flavour protection as the Minimal Flavour Violation in both quark and lepton sectors. Promoting the spurions to dynamical fields, the associated scalar potential is also studied and a minimum is identified such that fermion masses and mixings are correctly reproduced. Very precise predictions for the Majorana phases follow from the minimisation of the scalar potential and thus the neutrinoless-double-beta decay may represent a smoking gun for the model.
Speed Kills: Advancement in Th17 Cell Adoptive Cell Therapy for Solid Tumors
Authors: Fiering Steven N. , Ho Gregory W. 
Published: September 2020

Abstract
IL6 is targeted as part of treatment in adoptive cell therapy (ACT) because of its protumor effects and its role in the cytokine release syndrome. However, another major role of IL6 is to polarize naïve CD4+ T cells from Tregs to Th17 cells. While Th17 T cells are associated with autoimmunity, they are present around many different solid tumor cancers and their role in tumor microenvironments is unclear. In this issue of Cancer Research, Knochelmann and colleagues show that Th17 cells with less in vitro expansion in IL6-driven Th17 ACT provide greater solid tumor control and robust immune memory, highlighting advancement in the field of ACT application to solid tumor immunotherapy.
See related article by Knochelmann et al., p. 3920
Catch and Release: Mutant YAP as a Molecular Driver of Tumor Cell Dissemination
Authors: Davidson Shawn M. 
Published: September 2020

Abstract
The study by Benjamin and colleagues demonstrates that mutant YAP expression is sufficient to enhance tumor cell dissemination in zebrafish and mice. Moreover, the integration of approaches in biology and engineering taken here provides an important framework to link physical, physiological, and molecular properties of disseminated tumor cells (DTC). Similar integrated approaches will pave the way for future studies to generate global cancer cell dissemination maps and provide further insight into the prognostic value of DTCs for metastatic organotropisms.
See related article by Benjamin et al., p. 3867
Radiotheranostic Agent 64Cu-cyclam-RAFT-c(-RGDfK-)4 for Management of Peritoneal Metastasis in Ovarian Cancer
Authors: Jin Zhao-Hui , Tsuji Atsushi B. , Degardin Mélissa , Sugyo Aya , Obara Satoshi , Wakizaka Hidekatsu , Nagatsu Kotaro , Hu Kuan , Zhang Ming-Rong , Dumy Pascal , Boturyn Didier , Higashi Tatsuya 
Published: September 2020

Abstract

Purpose:
Ovarian cancer peritoneal metastases (OCPMs) are a pathophysiologically heterogeneous group of tumors that are rarely curable. αVβ3 integrin (αVβ3) is overexpressed on tumoral neovessels and frequently on ovarian cancer cells. Here, using two clinically relevant αVβ3-positive OCPM mouse models, we studied the theranostic potential of an αVβ3-specific radiopeptide, 64Cu-cyclam-RAFT-c(-RGDfK-)4 (64Cu-RaftRGD), and its intra- and intertumoral distribution in relation to the tumor microenvironment.

Experimental Design:
αVβ3-expressing peritoneal and subcutaneous models of ovarian carcinoma (IGR-OV1 and NIH:OVCAR-3) were established in nude mice. 64Cu-RaftRGD was administered either intravenously or intraperitoneally. We performed intratumoral distribution (ITD) studies, PET/CT imaging and quantification, biodistribution assay and radiation dosimetry, and therapeutic efficacy and toxicity studies.

Results:
Intraperitoneal administration was an efficient route for targeting 64Cu-RaftRGD to OCPMs with excellent tumor penetration. Using the fluorescence surrogate, Cy5.5-RaftRGD, in our unique high-resolution multifluorescence analysis, we found that the ITD of 64Cu-RaftRGD was spatially distinct from, but complementary to, that of hypoxia. 64Cu-RaftRGD–based PET enabled clear visualization of multiple OCPM deposits and ascites and biodistribution analysis demonstrated an inverse correlation between tumor uptake and tumor size (1.2–17.2 mm). 64Cu-RaftRGD at a radiotherapeutic dose (148 MBq/0.357 nmol) showed antitumor activities by inhibiting tumor cell proliferation and inducing apoptosis, with negligible toxicity.

Conclusions:
Collectively, these results demonstrate the all-in-one potential of 64Cu-RaftRGD for imaging guided radiotherapy of OCPM by targeting both tumoral neovessels and cancerous cells. On the basis of the ITD finding, we propose that pairing αVβ3- and hypoxia-targeted radiotherapies could improve therapeutic efficacy by overcoming the heterogeneity of ITD encountered with single-agent treatments.
TSPO-targeted PET and Optical Probes for the Detection and Localization of Premalignant and Malignant Pancreatic Lesions
Authors: Cohen Allison S. , Li Jun , Hight Matthew R. , McKinley Eliot , Fu Allie , Payne Adria , Liu Yang , Zhang Dawei , Xie Qing , Bai Mingfeng , Ayers Gregory D. , Tantawy Mohammed Noor , Smith Jarrod A. , Revetta Frank , Washington M. Kay , Shi Chanjuan , Merchant Nipun , Manning H. Charles 
Published: September 2020

Abstract

Purpose:
Pancreatic cancer is among the most aggressive malignancies and is rarely discovered early. However, pancreatic “incidentalomas,” particularly cysts, are frequently identified in asymptomatic patients through anatomic imaging for unrelated causes. Accurate determination of the malignant potential of cystic lesions could lead to life-saving surgery or spare patients with indolent disease undue risk. Current risk assessment of pancreatic cysts requires invasive sampling, with attendant morbidity and sampling errors. Here, we sought to identify imaging biomarkers of high-risk pancreatic cancer precursor lesions.

Experimental Design:
Translocator protein (TSPO) expression, which is associated with cholesterol metabolism, was evaluated in premalignant and pancreatic cancer lesions from human and genetically engineered mouse (GEM) tissues. In vivo imaging was performed with [18F]V-1008, a TSPO-targeted PET agent, in two GEM models. For image-guided surgery (IGS), V-1520, a TSPO ligand for near-IR optical imaging based upon the V-1008 pharmacophore, was developed and evaluated.

Results:
TSPO was highly expressed in human and murine pancreatic cancer. Notably, TSPO expression was associated with high-grade, premalignant intraductal papillary mucinous neoplasms (IPMNs) and pancreatic intraepithelial neoplasia (PanIN) lesions. In GEM models, [18F]V-1008 exhibited robust uptake in early pancreatic cancer, detectable by PET. Furthermore, V-1520 localized to premalignant pancreatic lesions and advanced tumors enabling real-time IGS.

Conclusions:
We anticipate that combined TSPO PET/IGS represents a translational approach for precision pancreatic cancer care through discrimination of high-risk indeterminate lesions and actionable surgery.
Revealing the Impact of Structural Variants in Multiple Myeloma
Authors: Rustad Even H. , Yellapantula Venkata D. , Glodzik Dominik , Maclachlan Kylee H. , Diamond Benjamin , Boyle Eileen M. , Ashby Cody , Blaney Patrick , Gundem Gunes , Hultcrantz Malin , Leongamornlert Daniel , Angelopoulos Nicos , Agnelli Luca , Auclair Daniel , Zhang Yanming , Dogan Ahmet , Bolli Niccolò , Papaemmanuil Elli , Anderson Kenneth C. , Moreau Philippe , Avet-Loiseau Hervé , Munshi Nikhil C. , Keats Jonathan J. , Campbell Peter J. , Morgan Gareth J. , Landgren Ola , Maura Francesco 
Published: September 2020

Abstract

The landscape of structural variants (SV) in multiple myeloma remains poorly understood. Here, we performed comprehensive analysis of SVs in a large cohort of 752 patients with multiple myeloma by low-coverage long-insert whole-genome sequencing. We identified 68 SV hotspots involving 17 new candidate driver genes, including the therapeutic targets BCMA (TNFRSF17), SLAM7, and MCL1. Catastrophic complex rearrangements termed chromothripsis were present in 24% of patients and independently associated with poor clinical outcomes. Templated insertions were the second most frequent complex event (19%), mostly involved in super-enhancer hijacking and activation of oncogenes such as CCND1 and MYC. Importantly, in 31% of patients, two or more seemingly independent putative driver events were caused by a single structural event, demonstrating that the complex genomic landscape of multiple myeloma can be acquired through few key events during tumor evolutionary history. Overall, this study reveals the critical role of SVs in multiple myeloma pathogenesis.

Significance:
Previous genomic studies in multiple myeloma have largely focused on single-nucleotide variants, recurrent copy-number alterations, and recurrent translocations. Here, we demonstrate the crucial role of SVs and complex events in the development of multiple myeloma and highlight the importance of whole-genome sequencing to decipher its genomic complexity.
See related commentary by Bergsagel and Kuehl, p. 221.
This article is highlighted in the In This Issue feature, p. 215