bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metallothionein 2A gene polymorphisms in relation to diseases and trace element levels in humans
Authors: Sekovanić Ankica , Jurasović Jasna , Piasek Martina 
Published: April 2020

Abstract
Human metallothioneins are a superfamily of low molecular weight intracellular proteins, whose synthesis can be induced by essential elements (primarily Zn and Cu), toxic elements and chemical agents, and stress-producing conditions. Of the four known isoforms in the human body MT2 is the most common. The expression of metallothioneins is encoded by a multigene family of linked genes and can be influenced by single nucleotide polymorphisms (SNPs) in these genes. To date, 24 SNPs in the MT2A gene have been identified with the incidence of about 1 % in various population groups, and three of them were shown to affect physiological and pathophysiological processes. This review summarises current knowledge about these three SNPs in the MT2A gene and their associations with element concentrations in the body of healthy and diseased persons. The most investigated SNP is rs28366003 (MT2A −5 A/G). Reports associate it with longevity, cancer (breast, prostate, laryngeal, and in paranasal sinuses), and chronic renal disease. The second most investigated SNP, rs10636 (MT2A +838G/C), is associated with breast cancer, cardiovascular disease, and type 2 diabetes. Both are also associated with several metal/metalloid concentrations in the organism. The third SNP, rs1610216 (MT2A −209A/G), has been studied for association with type 2 diabetes, cardiomyopathy, hyperglycaemia, and Zn concentrations. Metallothionein concentrations and MT2A polymorphisms have a potential to be used as biomarkers of metal exposure and clinical markers of a number of chronic diseases. This potential needs to be studied and verified in a large number of well-defined groups of participants (several hundreds and thousands) with a focus on particular physiological or pathological condition and taking into consideration other contributing factors, such as environmental exposure and individual genetic and epigenetic makeup.
Numerical aspects of two coupled harmonic oscillators
Authors: Asad Jihad , Florea Olivia 
Published: April 2020

Abstract
In this study an interesting symmetric linear system is considered. As a first step we obtain the Lagrangian of the system. Secondly, we derive the classical Euler- Lagrange equations of the system. Finally, numerical and analytic solution for these equations have been presented for some chosen initial conditions.
Comment On “On some Properties of Tribonacci Quaternion”
Authors: Cerda-Morales Gamaliel 
Published: April 2020

Abstract
This short commentary serves as a correction of the paper by Akkus and Kızılaslan [I. Akkus and G. Kızılaslan, On some Properties of Tribonacci Quaternion, An. Şt. Univ. Ovidius Constanţa, 26(3), 2018, 5–20].
Estimates of the Laplacian Spectrum and Bounds of Topological Invariants for Riemannian Manifolds with Boundary II
Authors: Sabatini Luca 
Published: April 2020

Abstract
We present some estimate of the Laplacian Spectrum and of Topological Invariants for Riemannian manifold with pinched sectional curvature and with non-empty and non-convex boundary with finite injectivity radius. These estimates do not depend directly on the the lower bound of the boundary injectivity radius but on the bounds of the curvatures of the manifold and its boundary.
A modified Tikhonov regularization method for a class of inverse parabolic problems
Authors: Saouli Nabil , Zouyed Fairouz 
Published: April 2020

Abstract
This paper deals with the problem of determining an unknown source and an unknown initial condition in a abstract final value parabolic problem. This problem is ill-posed in the sense that the solutions do not depend continuously on the data. To solve the considered problem a modified Tikhonov regularization method is proposed. Using this method regularized solutions are constructed and under boundary conditions assumptions, convergence estimates between the exact solutions and their regularized approximations are obtained. Moreover numerical results are presented to illustrate the accuracy and efficiency of the proposed method.
The commutative quotient structure of m-idempotent hyperrings
Authors: Zadeh Azam Adineh , Norouzi Morteza , Cristea Irina 
Published: April 2020

Abstract
The α* -relation is a fundamental relation on hyperrings, being the smallest strongly regular relation on hyperrings such that the quotient structure R/α* is a commutative ring. In this paper we introduce on hyperrings the relation ζ
m
, which is smaller than α*, and show that, on a particular class of m-idempotent hyperrings R, it is the smallest strongly regular relation such that the quotient ring R/ζ
*

m
is commutative. Some properties of this new relation and its differences from the α* -relation are illustrated and discussed. Finally, we show that ζ
m
is a new representation for α* on this particular class of m-idempotent hyperrings.
Polish Adaptation of the Cross-Cultural Competence Inventory: An Overview
Authors: Barzykowski Krystian , Majda Anna , Przyłęcki Paweł 
Published: April 2020

Abstract

Introduction. The growing cultural diversity of Polish society creates new challenges for people who, in their professional activities, deal with culturally divergent people. Therefore, on the one hand, there is an urgent need for education and development in cross-cultural competences; on the other hand, there is a need to measure these competences with reliable and accurate methods.

Aim. The goal of the present paper is recommendation of the Polish adaptation of the Cross-Cultural Competence Inventory (CCCI). In addition, the paper discusses the possible usage of the CCCI within the Polish healthcare system.

Methods. The CCCI was adapted to Polish in a multistage process [1]. Briefly, it consisted of two studies, with 455 (Study 1) and 347 (Study 2) participants, in which the psychometric properties of the CCCI were evaluated in terms of reliability, internal consistency, factorial structure, test-retest reliability, and theoretical validity, criterion and convergent validity.

Results. Although the original version of the CCCI was assumed to have a 6-dimensional factor structure, confirmatory factor analysis did not provide strong evidence for this assumption. However, as demonstrated in two studies, the Polish adaptation of the CCCI has satisfactory psychometric properties, such as reliability and validity (theoretical, criterion and convergent).

Conclusions. Results of Study 1 and Study 2 support the conclusion that the CCCI can be successfully used in empirical research among healthcare professionals and students of medical courses. Future work may focus on further improvements of the CCCI by, for example, developing Polish standardized norms for different groups of professionals.
Nursing – why? Students’ motives for choosing nursing as a field of education
Authors: Lemiecha Agnieszka , Leńczuk-Gruba Anna 
Published: April 2020

Abstract

Introduction. The decision on a course of study related to the profession of choice is a milestone in many people’s life. The choice of nursing is determined by various reasons and values which can influence both the involvement and satisfaction of students with their education and later, professional life.

Aim. To learn the reasons and values behind choosing nursing education.

Material and methods. The survey was performed in January 2019 on a group of 223 1st grade nursing students at the Medical University of Warsaw. The survey used an original questionnaire and the standardized List of Personal Values (PVL) by Z. Jurczyński.

Results. Within the group of participating students – 34.1% chose nursing as their first recruitment choice of studies. The majority justified their choice with the will to help others and the need to acquire higher education. The personal values declared by the students were mostly love, friendship and good health, physical and mental fitness. The meaning of ”good material conditions” as a token of personal happiness (p=0.005) was more often declared by students for whom nursing was not the first choice of education.

Conclusions. Only a third of the respondents chose nursing education consciously. The most commonly declared reason behind the choice of nursing profession was the will to help other people. Students, who chose nursing as their one and only education less frequently declared the importance of good material conditions as a symbol of personal happiness.
Analisis Kesalahan Siswa dalam Menilai Kebenaran Suatu Pernyataan
Authors: Setiawan Yayan Eryk 
Published: April 2020

The reasonings students provided in assessing the truth of a statement still show many mistakes. Therefore, this present research aimed to find the students’ errors in judging the truth of a statement. The present research employed a qualitative approach, and the participants were 10th-grade senior high school students in one of Lumajang district. This research instrument consisted of three questions demanding evaluative abilities. The findings showed that the students made three kinds of errors reasoning in judging the truth of the statements, which are conceptual errors, principle errors, and factual errors. This study is implied to the Mathematics teachers to provide students opportunities to construct definitions, distinguish the differences among the characteristics of two and three-dimensional figures, and to explain the meaning of mathematical symbols in various contexts to avoid conceptual errors, principle errors, and factual errors.
Multiplikasi Tunas In Vitro Anggrek Phalaenopsis dan Analisis Keragaman Genetik dengan Marka SNAP
Authors: Mira Humaira  , Agus Purwito  , Sudarsono  , Sukma Dewi 
Published: April 2020

Perbanyakan klonal anggrek melalui kultur in vitro dibutuhkan untuk memperoleh sejumlah besar propagul tanaman yang berkualitas. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh konsentrasi BAP terhadap kemampuan multiplikasi tunas dalam propagasi klonal beberapa anggrek hibrida Phalaenopsis dan menganalisis keragaman genetik menggunakan marka Pto-SNAP pada planlet klonal. Percobaan dilakukan secara terpisah pada 3 populasi tunas anggrek hibrida Phalaenopsis yaitu, tunas hasil perkecambahan biji dari Phal. amabilis x Phal. ‘KHM 421’ dengan 5 taraf perlakuan BAP (0.00, 11.09, 22.19, 33.29, 44.39 µM), tunas klon Phal. ‘Salu Spot’ x Phal. bellina ‘1102-38’ dan Phal. ‘Salu Spot’ x Phal. bellina ‘1102-44’ dengan 4 taraf perlakuan BAP (11.09, 22.19, 33.29, 44.39 µM). Hasil penelitian menunjukkan bahwa konsentrasi BAP terbaik untuk multiplikasi tunas pada tiga populasi yang diuji adalah 22.19 µM dengan jumlah tunas masing-masing 3.7, 4.7 dan 6.0 tunas pada 12 minggu setelah tanam (MST). Protocorm like bodies (PLBs) hanya dihasilkan pada populasi Phal. amabilis x Phal. ‘KHM 421’ dengan jumlah PLBs terbanyak perlakuan BAP 11.09 µM. Evaluasi keragaman genetik menggunakan 11 marker Pto-SNAP (single nucleotide amplified polymorphism) dilakukan pada planlet klonal Phal. ‘Salu Spot’ x Phal. bellina ‘1102-44’. Hasil analisis menunjukkan adanya variasi somaklonal dari planlet yang diuji perlakuan BAP 22.19 µM dengan keragaman 7.7% pada lokus Pto-241 dan perlakuan BAP 44.39 µM dengan persen keragaman 11.1% pada lokus Pto-424.
Kata kunci: marka molekuler, propagasi klonal, Pto, sitokinin, variasi somaklonal
Penghambatan Pertumbuhan Gulma Commelina diffusa oleh Pemberian Ekstrak Segar Daun Mikania micrantha
Authors: Widiastuti Natalia Puteri , Zaman Sofyan , Sudradjat  
Published: April 2020

Commelina diffusa Burm. F. diketahui telah resisten terhadap beberapa jenis herbisida sehingga alternatif pengendalian gulma tersebut perlu diketahui. Mikania micrantha merupakan salah satu jenis gulma yang mengandung senyawa alelopati yang dapat menekan pertumbuhan tanaman di sekitarnya sehingga berpotensi digunakan sebagai bioherbisida. Penelitian ini bertujuan mengetahui potensi ekstrak daun M. micrantha sebagai bioherbisida untuk menghambat pertumbuhan gulma C. diffusa. Penelitian dilaksanakan di Kebun Percobaan Cikabayan dan Laboratorium Pascapanen, Institut Pertanian Bogor pada bulan April-Juni 2019. Rancangan percobaan yang digunakan adalah rancangan kelompok lengkap teracak (RKLT) faktor tunggal yaitu konsentrasi ekstrak daun M. micrantha sebesar 0.00, 0.33, 0.67, 1.00, 1.33, 1.67, dan 2.00 g bobot basah mL-1, dengan 4 ulangan. Aplikasi ekstrak daun M. micrantha mengurangi jumlah daun, meningkatkan skor toksisitas, dan meningkatkan persentase kematian gulma C. diffusa. Hasil penelitian menunjukkan bahwa aplikasi ekstrak daun M. micrantha menekan pertumbuhan daun C. diffusa sampai 2 minggu setelah aplikasi (MSA). Ekstrak daun M. micrantha bersifat toksik bagi pertumbuhan C. diffusa pada 1 MSA dan menyebabkan kematian C. diffusa mulai 10-15 hari setelah aplikasi. Konsentrasi ekstrak daun M. micrantha yang menyebabkan toksisitas pada C. diffusa adalah 1.15 g mL-1.
Kata kunci: bioherbisida, gulma, konsentrasi ekstrak, resisten, senyawa alelopati
Interaksi Genotipe × Musim Karakter Percabangan Malai Tiga Genotipe Padi Sawah
Authors: Hastini Tri , Willy Bayuardi Suwarno  , Munif Ghulamahdi  , Hajrial Aswidinnoor  
Published: April 2020

Percabangan malai merupakan salah satu kunci penentu hasil padi, namun keragaannya antar musim belum banyak dipelajari hingga saat ini. Penelitian ini bertujuan untuk mendapatkan informasi tentang interaksi genotipe × musim karakter percabangan malai padi. Percobaan dilaksanakan dari bulan April 2017 sampai dengan Maret 2018, di Kebun Percobaan IPB Babakan, Dramaga, Bogor. Lima belas genotipe padi sawah sebagai perlakuan ditanam pada musim kemarau dan musim hujan untuk mempelajari interaksi genotipe × musim. Percobaan ditata dalam rancangan acak kelompok lengkap dengan empat ulangan. Analisis yang dilakukan adalah analisis ragam per musim dan analisis ragam gabungan antar musim. Hasil percobaan menunjukkan bahwa genotipe, musim, dan interaksi genotipe × musim berpengaruh nyata pada karakter panjang malai, jumlah cabang primer, panjang cabang primer, dan panjang cabang sekunder. Informasi yang diperoleh dari hasil penelitian ini dapat bermanfaat bagi pemulia padi dalam melakukan seleksi pada karakter percabangan malai.
Kata kunci: genotipe × musim, musim kemarau, musim hujan, pemuliaan padi
Perbedaan Tanggap Morfologi Akar Galur Inbrida Sorgum pada Kondisi P Rendah
Authors: Putri Andini Mandasari  , Wirnas Desta , Trikoesoemaningtyas  , Sopandie Didy 
Published: April 2020

Akar tanaman memiliki respon yang bervariasi sebagai bentuk adaptasi pada kondisi P rendah. Penelitian ini bertujuan untuk memperoleh informasi tanggap morfologi akar dari galur-galur inbrida sorgum pada kondisi P rendah. Percobaan ini menggunakan rancangan kelompok lengkap teracak (RKLT) tersarang dua faktor yaitu genotipe dan dosis pupuk P. Genotipe yang digunakan terdiri atas 11 galur inbrida sorgum (RIL-F8), tetua peka (B-69), tetua toleran (Numbu) dan 2 varietas nasional (WHP dan Kawali). Dosis pupuk yang digunakan terdiri atas dosis P cukup (66.76 kg ha-1 P2O5) dan P rendah (33.38 kg ha-1 P2O5). Hasil penelitian menunjukkan bahwa terdapat perbedaan tanggap morfologi akar di antara galur-galur inbrida (RIL-F8) sorgum pada kondisi P rendah. Galur-galur toleran memiliki panjang akar terpanjang (41.33-61.87 cm), volume akar (8.87-12.87 mL), diameter akar terpanjang (0.88-1.02 mm) dan jumlah akar proteoid (2.4-4.0) yang lebih tinggi dibandingkan galur-galur peka pada kondisi P rendah. Karakter-karakter tersebut mendukung tingginya biomassa galur toleran pada kondisi P rendah, sehingga menjadi karakter penting untuk seleksi adaptasi akar pada kondisi P rendah.
Kata kunci: akar proteoid, biomassa, fosfor, toleran
Stabilitas Laju Fotosintesis dan Produktivitas Rimpang Genotipe Curcuma aeruginosa dan Curcuma zanthorrhiza
Authors: Djarot Sasongko Hami Seno  , Mohamad Rafi  , Maria Bintang  , Popy Asri Kurniatin  , Waras Nurcholis  
Published: April 2020

Curcuma aeruginosa Roxb. rhizome is an essential herb material with significant antimicrobial, anticancer, and antioxidant activities. Thus, it is important to search for C. aeruginosa plant that has the rhizome yield trait with more excellent stability in changing environmental situations. This research aimed to evaluate the genotype x environment interaction using additive main effects and multiple interaction (AMMI) analysis for photosynthetic rate and rhizome yield of C. aeruginosa genotypes. Twenty clones of C. aeruginosa plus three control varieties of C. zanthorrhiza Roxb. were evaluated in three environments (Bogor, Cianjur, and Sukabumi) using a randomized complete block design with three replicates. The photosynthetic rate and rhizome yield showed significantly (p < 0.01) genotype x environment interaction. The AMMI2 explained 100% variability of the photosynthetic rate and rhizome yield parameters. G2, G10, G12, G13, G14, G16, G17, G19, and G20 were stable genotypes for rhizome yield based on AMMI analyses. Meanwhile, the stable genotype in photosynthetic rate recorded in G4, G5, G6, G8, G11, G13, and G14.
Keywords: AMMI, genotypes, multilocation trials, pink and blue ginger, varieties
Green CSR Moderated by Public Visibility and Innovation Performance at Indonesia Companies
Authors: Farah Margaretha Leon Rahmat Hidayat, 
Published: April 2020

This study aims to analyze the green CSR of innovation performance with firms approval variables and public visibility can support moderating the relationship of green CSR and innovation. The research sample was 33 manufacturing companies. The results showed that the green CSR has a positive and significant effect on innovation . Also, the company approval variable has been proven to moderate the direction of a positive relationship between green CSR and innovation . The results also prove that public visibility is proven to moderate the direction of the negative relationship between green CSR and performance. This study provide information that shows great concern for the environment; it will increase the company in making changes through innovation activities. Also, the higher the company's approval and public visibility, the company will get support from various stakeholders to run the firms. The level of company concern for CSR activities will be a misjudgment for investors.
Identifikasi Isolat Klinik Methicillin-resistant Staphylococcus aureus dan Extended-Spectrum Beta-Lactamase Menggunakan Teknik Polimerase Chain Reaction
Authors: Linosefa Linosefa 
Published: April 2020

Bakteri patogen yang resisten terhadap banyak obat seperti Staphylococcus aureus yang kebal terhadap Methicillin (Methicillin-resistant Staphylococcus aureus/MRSA) telah menjadi agen penyebab infeksi baik di lingkungan pelayanan kesehatan maupun di masyarakat. Extended-Spectrum Beta-Lactamase (ESBL) yang berasal dari mutasi β-laktamase juga menjadi masalah utama dalam infeksi terkait pelayanan kesehatan. Tujuan: Menentukan proporsi bakteri penghasil MRSA dan ESBL dari isolat klinis di Rumah Sakit Dr. M. Djamil Padang menggunakan teknik Polimerase Chain Reaction (PCR). Metode: Penelitian ini merupakan studi prospektif dengan mengumpulkan isolat Staphylococcus aureus dan Enterobacteriaceae dari Juli hingga September 2017. Penelitian dilakukan di Fakultas Kedokteran Universitas Andalas untuk mengkonfirmasi bakteri penghasil MRSA dan ESBL. Hasil: Sebanyak 15 dari 27 isolat Staphylococcus aureus (56%) merupakan MRSA dan 21 dari 41 isolat Enterobacteriaceae (51%) adalah penghasil ESBL. Klebsiella sp. paling banyak ditemukan di antara isolat Enterobacteriaceae (59%). Lima puluh persen Klebsiella sp menghasilkan ESBL. Simpulan: Studi ini menunjukkan bahwa setengah isolat klinis dari RSUP Dr. M. Djamil merupakan MRSA dan penghasil ESBL. Deteksi dini MRSA dan Enterobacteriaceae penghasil ESBL perlu dilakukan, untuk mencegah dan mengurangi transmisi bakteri MDR di lingkungan rumah sakit.Kata kunci: Enterobacteriaceae, Klebsiella sp, MDR, Staphylococcus aureus
Posterior Shoulder Instability Classification, Assessment, and Management: An International Delphi Study
Authors: Sadi Jackie , Torchia Erik , Faber Kenneth J. , Macdermid Joy , Lalonde Corinne , Watson Lyn , Weber Marjorie , Wu Nan 
Published: April 2020

Objective To reach consensus among international shoulder experts on the most appropriate assessment and management strategies for posterior shoulder instability (PSI). Design Delphi. Methods In phase 1 of the study, we reviewed the literature, generated the Delphi items, created the survey, and identified clinical experts. In phase 2 of the study, clinical shoulder experts (physical therapists, orthopaedic surgeons, sports medicine physicians, and researchers) participated in a 3-round e-Delphi survey. For consensus, we required a minimum of 70% agreement per round. Descriptive statistics were used to present the characteristics of the respondents, the response rate of the experts in each round, and the consensus for PSI classification, assessment, and management. Results Round 3 was completed by 47 individuals from 5 different countries. The response rate ranged from 57/70 (81%) to 47/50 (94%) per round. Respondents agreed on 3 subgroups to define PSI: traumatic (100% agreement), microtraumatic (98% agreement), and atraumatic (98% agreement). Conclusion International shoulder experts agreed that the clinical presentation, management strategy, and outcome expectations differ for traumatic, microtraumatic, and atraumatic PSI. Their recommendations provide a framework for managing these subgroups, with additional consideration of sport and work participation and subsequent risks. J Orthop Sports Phys Ther 2020;50(7):373–380. Epub 29 Apr 2020. doi:10.2519/jospt.2020.9225
Principais características da ação da melatonina no corpo humano: uma revisão literária
Authors: Britto Diana Babini Lapa de Albuquerque , Costa Luis Filipi Souza de Britto , Tenório Bruno Mendes , Maia Carina Scanoni , Gomes José Anderson  da Silva , Guedes Geovanna Hachyra Facundo , De Oliveira Maria Luísa Figueira , De Medeiros Juliana Pinto , Lapa Vanessa Silva , Tenório Fernanda Chagas Ângelo Mendes 
Published: April 2020

Objetivo: descrever as principais características da ação da melatonina sobre o corpo humano. Revisão Bibliográfica: Atualmente, pesquisas vêm acontecendo com propósito de descobrir cada vez mais sobre as ações da melatonina (MEL) em humanos. A literatura descreve como sendo o hormônio do sono, fundamental no ritmo circadiano do corpo humano. Diversas ações fisiológicas da MEL ocorrem através da sua interação com receptores de membrana, chamados: MT1 e MT2. Além disso, apresenta um papel importante durante o ciclo da vida. Atingem os maiores valores nos niveis séricos no desenvolvimento da criança e fase prépubere. Sofre diminuição progressiva na puberdade, descrescendo bastante com o envelhecimento. Atualmente os estudos relatam que a MEL vem apresentando ação antioxidante, anti-inflamatória, antioncostática e, também, na eliminação de radicais livres. Também apresenta ação otoprotetora, importante ação na placenta no período gestacional e ainda atua no sistema genital feminino. Considerações finais: Conclui-se, desta forma, que a melatonina tem um papel fundamental no ritmo circadiano do corpo humano bem como em tratamento com ações protetoras no corpo, podendo, ser utilizado em pesquisas para que haja um maior avanço científico através da sua aplicabilidade em diversas áreas da saúde que poderão ser aplicadas futuramente em tratamento cada vez mais específico.