bluuebunny/crossref_metadata_2025_split huggingface dataset:
Responsive Fluorophore Aggregation Provides Spectral Contrast for Fluorescence Lifetime Imaging
Authors: Schleyer Kelton A. , Datko Benjamin D. , Burnside Brandon , Cui Chao , Ma Xiaowei , Grey John K. , Cui Lina 
Published: March 2020

AbstractFluorophores experience altered emission lifetimes when incorporated into and liberated from macromolecules or molecular aggregates; this trend suggests the potential for a fluorescent, responsive probe capable of undergoing self‐assembly and aggregation and consequently altering the lifetime of its fluorescent moiety to provide contrast between the active and inactive probes. We developed a cyanobenzothioazole‐fluorescein conjugate (1), and spectroscopically examined the lifetime changes caused by its reduction‐induced aggregation in vitro. A decrease in lifetime was observed for compound 1 in a buffered system activated by the biological reducing agent glutathione, thus suggesting a possible approach for designing responsive self‐aggregating lifetime imaging probes.
Ethinylestradiol and its effects on the macrophages in the prostate of adult and senile gerbils
Authors: Castro Nayara F. C. , Falleiros‐Júnior Luiz R. , Zucão Mariele I. , Perez Ana P. S. , Taboga Sebastião R. , Santos Fernanda C. A. , Vilamaior Patrícia S. L. 
Published: March 2020

AbstractPrenatal and neonatal exposure to estrogenic compounds, such as ethinylestradiol (EE), promotes a variety of developmental disorders, including malformations and alterations in the morphology of glands, such as the prostate gland. Therefore, the aim of this study was to evaluate the morphological effects of neonatal exposure to EE on prostatic tissue and on the identification and quantification of gerbil gland macrophages in adult and senile Mongolian gerbils. The animals were exposed to EE (10 μg/kg/day) and to the vehicle, mineral oil (100 μL) (control group) during the first 10 days of postnatal life (lactation period). Adult gerbils were euthanized at 120 days and senile gerbils at 12 months of age. Our findings permitted verification of the presence of areas with proliferative foci in the prostate glandular portions in the adult and senile animals exposed to EE. There was also an increase in macrophages in the prostate tissue of adult and senile gerbils; these cell types alter the stromal microenvironment and possibly modify the interactions between the epithelium and stroma. Neonatal exposure to EE changes the pattern of prostatic development, leading to alterations in the arrangement of cells, including macrophages, and may be related to the onset of proliferative disorders in the prostate of adult gerbils and during aging.
Comparison of post‐stent optical coherence tomography findings among three subtypes of calcified culprit plaques in patients with acute coronary syndrome
Authors: Nakajima Akihiro , Araki Makoto , Kurihara Osamu , Minami Yoshiyasu , Soeda Tsunenari , Yonetsu Taishi , Crea Filippo , Takano Masamichi , Higuma Takumi , Kakuta Tsunekazu , Adriaenssens Tom , Lee Hang , Nakamura Sunao , Jang Ik‐Kyung 
Published: March 2020

AbstractObjectivesTo compare the postprocedural optical coherence tomography (OCT) findings and in‐hospital outcomes among the three subtypes of calcified plaques: eruptive calcified nodules, superficial calcific sheet, and calcified protrusion.BackgroundRecently, three subtypes of calcified culprit plaques were reported in patients with acute coronary syndrome (ACS). How these subtypes respond to stenting is unknown.MethodsACS patients with calcified plaque at the culprit lesion were selected from our database. OCT findings at baseline and after stent implantation were compared.ResultsIn the final analysis, 87 cases were included. Preprocedural OCT showed eruptive calcified nodules in 19 (21.8%) cases, superficial calcific sheet in 63 (72.4%), and calcified protrusion in 5 (5.7%). Stent edge dissection (SED) and incomplete stent apposition (ISA) were frequently observed in the eruptive calcified nodules group compared to superficial calcific sheet or calcified protrusion (SED; 47.4% vs. 17.5% vs. 20.0%; p = .032, ISA; 94.7% vs. 58.7% vs. 0.0%; p < .001). The superficial calcific sheet group had the smallest minimal stent area (MSA) among the three groups (eruptive calcified nodules vs. superficial calcific sheet vs. calcified protrusion: 6.29 ± 2.41 vs. 4.72 ± 1.37 vs. 6.56 ± 1.13; p = .007). The superficial calcific sheet group had a higher rate of periprocedural myocardial infarction compared to the eruptive calcified nodules group (60.3% vs. 31.6%; p = .028).ConclusionsThis study demonstrated eruptive calcified nodules are associated with higher incidence of SED and ISA, whereas superficial calcific sheets are associated with small MSA and higher periprocedural myocardial infarction.
Institutional learning experience for combined edge‐to‐edge tricuspid and mitral valve repair
Authors: Mahowald Madeline K. , Pislaru Sorin V. , Reeder Guy S. , Padang Ratnasari , Michelena Hector I. , Mankad Sunil V. , Maalouf Joseph F. , Guerrero Mayra , Alkhouli Mohamad , Rihal Charanjit S. , Eleid Mackram F. 
Published: March 2020

AbstractBackgroundTranscatheter edge‐to‐edge repair with MitraClip is only approved for treatment of mitral regurgitation but is increasingly used to treat concomitant tricuspid regurgitation (TR) due to its common coexistence and association with poor outcomes. This study aimed to describe the learning curve associated with the challenge of off‐label treatment of concomitant TR.MethodsThis is a retrospective review of initial and consecutive patients who underwent combined edge‐to‐edge repair of mitral and tricuspid valves (TVs) at our institution from August 2017 to October 2019.ResultsRepair of both valves with MitraClip was performed in 22 patients (median age 81.5 years, 32% female). Mean procedure time was 176 ± 47 min; mean fluoroscopy time was 65 ± 24 min. Procedure duration in the first tertile was significantly longer (223 ± 13 min) than in the third tertile (143 ± 23 min, p = .0003). Median number of total clips placed per case was 3; in 15 patients (68%), the anterior and septal leaflets of the TV were clipped. The average changes in mean right atrial (RA) and left atrial (LA) pressures were −1.7 ± 2.5 mmHg (p = .0080) and −3.2 ± 4.6 mmHg (p = .0045), respectively. The average changes in RA and LA V‐wave heights were −3.3 ± 4.0 mmHg (p = .0009) and −8.1 ± 9.9 mmHg (p = .038), respectively. There was a significant trend toward decreasing residual TR over the course of the series (p = .046). At 30 days, survival was 100% and mean NYHA class decreased from 2.8 to 1.8 (p < .0001).ConclusionsCombined edge‐to‐edge tricuspid and mitral valve repair is safe and feasible. With experience, procedure duration and residual TR decreased.
Sub‐5 nm Intermetallic Nanoparticles Confined in Mesoporous Silica Wells for Selective Hydrogenation of Acetylene to Ethylene
Authors: Maligal‐Ganesh Raghu V. , Pei Yuchen , Xiao Chaoxian , Chen Minda , Goh Tian Wei , Sun Weijun , Wu Jiashu , Huang Wenyu 
Published: March 2020

AbstractWe report the synthesis and catalytic application of intermetallic PtSn nanoparticles confined in MSWs (Mesoporous Silica Wells) in the semi‐hydrogenation of acetylene. Platinum nanoparticles with a size of 2.9 nm supported on amine‐functionalized ∼180 nm silica spheres were enmeshed in a mesoporous silica shell. After the addition of tin via a polyol synthesis method, we obtained the final PtSnx@MSW (x=0.30, 0.50, 0.70, 1.0 and 2.0). Owing to the mesoporous encapsulation the sub‐5 nm bimetallic particles are shown to be monodisperse and well protected against aggregation on the silica sphere even under high‐temperature treatment conditions. In the gas phase semi‐hydrogenation of acetylene, the PtSn@MSW with Sn/Pt molar ratios equal to or greater than one displayed higher selectivity to ethylene. Meanwhile, increasing Sn content decreases acetylene conversion. The intermetallic PtSn@MSW catalysts also displayed long‐term stability and regenerability due to the confined environment provided by MSW.
Plasmonic Electrons‐Driven Solar‐to‐Hydrocarbon Conversion over Au NR@ZnO Core‐Shell Nanostructures
Authors: Shen Jinni , Chen Zhenye , Han Shitong , Zhang Hongwen , Xu Hailing , Xu Chao , Ding Zhengxin , Yuan Rusheng , Chen Jinquan , Long Jinlin 
Published: March 2020

AbstractThis work demonstrates the long‐range redox reactivity of gold plasmon‐generated hot electrons for solar‐driven CO2 conversion. A series of Au NR@ZnO core‐shell photocatalysts with a tunable shell thickness are rationally designed to achieve the solar‐to‐CH4 conversion, where the hot plasmonic electrons‐induced photoreduction takes place on the polar oxide moiety. The shell thickness‐independent activity implies that the core, gold nanorods, plays a dominant role in the CH4 generation. The ZnO metal oxide semiconductor shell is beneficial to prolong the lifetime of hot electrons, thereby enhancing the photocatalytic efficiency. However, the thickness of ZnO shell is not relevant to the production rate. Both of these two parts are co‐excited by solar light and synergetic enhance the photocatalytic activity.
Electride‐Sponsored Radical‐Controlled CO2Reduction to Organic Acids: A Computational Design
Authors: Qi Mengyu , Tang Chuankai , Zhou Zhongjun , Ma Fang , Mo Yirong 
Published: March 2020

AbstractConverting CO2into high‐value chemicals has been regarded as an important solution for a sustainable low‐carbon economy. In this work, we have theoretically designed an innovative strategy for the absorption and activation of CO2by the electride N3Li, that is, 1,3,5(2,6)‐tripyridinacyclohexaphane (N3) intercalated by lithium. DFT computations showed that the interaction of CO2with N3Li leads to the catalytic complex N3Li(η2‐O2C), which can initiate the radical‐controlled reduction of another CO2to form organic acids through radical reactions in the gas phase. The CO2reduction consists of four steps: (1) The formation of N3Li(η2‐O2C) through the combination of N3Li and CO2, (2) hydrogen abstraction from RH (R=H, CH3, and C2H5) by N3Li(η2‐O2C) to form the radical R.and N3Li(η2‐O2C)H, (3) the combination of CO2and the radical R.to form RCOO., and (4) intermolecular hydrogen transfer from the intermediate N3Li(η2‐O2C)H to RCOO.. In the whole reaction process, the CO2moiety in the complex N3Li(η2‐O2C) maintains a certain radical character at the carbon atom of CO2and plays a self‐catalyzing role. This work represents the first example of electride‐sponsored radical‐controlled CO2reduction, and thus provides an alternative strategy for CO2conversion.
An Easy Access to Oxime Ethers byPd‐CatalyzedC—OCross‐Couplingof Activated Aryl Bromides with Ketoximes and Chalcone Oximes
Authors: Reeta  , Rangarajan T. M. , Singh Raj Pal , Singh R. P. , Singh Manjula 
Published: March 2020

Summary of main observation and conclusionAn efficient Pd‐catalyzed method for C—O cross‐coupling of ketoximes and chalcone oximes with activated aryl bromides and bromo‐chalcones has been developed. All oxime ethers were obtained in good to excellent yields by [(π‐allyl)PdCl]2/tBuXPhos (L7) catalyst system. TrixiePhos (L11) was also found to be effective for the oxime coupling. This method offers an easy and smooth coupling of chalcone oximes with activated aryl bromides and bromo‐chalcones, which has not been previously explored.
Substituent Effect Parameters: Extending the Applications to Organometallic Chemistry
Authors: Remya Geetha S. , Suresh Cherumuttathu H. 
Published: March 2020

AbstractTypically, metal complexes are constituted of an acceptor metal ion and one or more Iigands containing the donor atoms. Accordingly, the properties of a metal complex are equally dependent on the nature of the metal ion and the ligands. Minute structural variations in the ligand will may result in linear changes in the respective energetic parameters and such linear relationships have paramount importance in organometallic chemistry. The variation in ligands is virtually limitless and substantial because of the extent of organic chemistry available for the modelling of desirable ligands, apart from the variation in metal ions. Anyhow, there is still a need for new parameters for the design and quantification of new ligands which in turn leads to the synthesis of metal complexes with possibly predictable chemical properties. Previous studies have demonstrated that quantum chemically derived molecular electrostatic potential (MESP) parameters can be listed as one of the superior quantifiers in this regard, which can act as an effective ligand electronic parameter. The interaction between the ligand part and metal‐containing part will be crucial in assessing the reactivity of organometallic complexes. Here we are applying MESP based substituent constants derived from substituted benzenes to forecast the interaction energies in (pyr*)W(CO)5, (NHC*)Mo(CO)5 and (η6‐arene*)Cr(CO)3 complexes. Ligands and metal ions are varied in each case for better understanding and transparency.
Fluorescein‐Containing Superoxide Probes with a Modular Copper‐Based Trigger
Authors: Tang Fung Kit , Yu Zuo Hang , Wong Thomas Hin‐Fung , Chung Clive Yik‐Sham , Hirao Hajime , Au‐Yeung Ho Yu 
Published: March 2020

AbstractFluorescein‐derived superoxide probes featuring a copper(II) complex that can be activated by superoxide to initiate ether bond cleavage and uncage a fluorescein reporter for imaging in live cells are described. Compared to other superoxide sensing moieties, this bond cleavage strategy can be modularly adapted to fluorescent reporters with different properties without compromising the superoxide reactivity and selectivity. A green‐emitting probe and its lysosome‐targeting analogue have been successfully developed. Both probes are sensitive with more than 30‐fold fluorescence enhancement towards superoxide and are highly selective with no significant response towards other reactive oxygen species. A structure–activity relationship study of the copper‐based superoxide trigger showed that the secondary coordination environment of the copper(II) center is important for the superoxide reactivity and selectivity. The probes have been applied in imaging changes in intracellular superoxide level in live HeLa and HEK293T cells upon menadione stimulation and also in a cellular inflammation model in RAW 264.7 cells.
CO2‐Reductive, Copper Oxide‐Based Photobiocathode for Z‐Scheme Semi‐Artificial Leaf Structure
Authors: Kuk Su Keun , Jang Jinha , Kim Jinhyun , Lee Youngjun , Kim Young Sin , Koo Bonhyeong , Lee Yang Woo , Ko Jong Wan , Shin Byungha , Lee Jung‐Kul , Park Chan Beum 
Published: March 2020

AbstractGreen plants convert sunlight into high‐energy chemicals by coupling solar‐driven water oxidation in the Z‐scheme and CO2 fixation in the Calvin cycle. In this study, formate dehydrogenase from Clostridium ljungdahlii (ClFDH) is interfaced with a TiO2‐coated CuFeO2 and CuO mixed (ClFDH–TiO2|CFO) electrode. In this biohybrid photocathode, the TiO2 layer enhances the photoelectrochemical (PEC) stability of the labile CFO photocathode and facilitates the transfer of photoexcited electrons from the CFO to ClFDH. Furthermore, inspired by the natural photosynthetic scheme, the photobiocathode is combined with a water‐oxidizing, FeOOH‐coated BiVO4 (FeOOH|BiVO4) photoanode to assemble a wireless Z‐scheme biocatalytic PEC device as a semi‐artificial leaf. The leaf‐like structure effects a bias‐free biocatalytic CO2‐to‐formate conversion under visible light. Its rate of formate production is 2.45 times faster than that without ClFDH. This work is the first example of a wireless solar‐driven semi‐biological PEC system for CO2 reduction that uses water as an electron feedstock.
Layered data aggregation with efficient privacy preservation for fog‐assisted IIoT
Authors: Li Yalan , Chen Siguang , Zhao Chuanxin , Lu Weifeng 
Published: March 2020

SummaryThe emergence of fog computing facilitates industrial Internet of Things (IIoT) to be more real‐time and efficient; in order to achieve secure and efficient data collection and applications in fog‐assisted IIoT, it usually sacrifices great computation and bandwidth resources. From the low computation and communication overheads perspective, this paper proposes a layered data aggregation scheme with efficient privacy preservation (LDA‐EPP) for fog‐assisted IIoT by integrating the Chinese remainder theorem (CRT), modified Paillier encryption, and hash chain technology. In LDA‐EPP scheme, the entire network is divided into several subareas; the fog node and cloud are responsible for local and global aggregations, respectively. Specially, the cloud is able to obtain not only the global aggregation result but also the fine‐grained aggregation results of subareas, which enables that can provide fine‐grained data services. Meanwhile, the LDA‐EPP realizes data confidentiality by the modified Paillier encryption, ensures that both outside attackers and internal semi‐trusted nodes (such as, fog node and cloud) are unable to know the privacy data of individual device, and guarantees data integrity by utilizing simply hash chain to resist tempering and polluting attacks. Moreover, the fault tolerance is also supported in our scheme; ie, even though some IIoT devices or channel links are failure, the cloud still can decrypt incomplete aggregation ciphertexts and derive expected aggregation results. Finally, the performance evaluation indicates that our proposed LDA‐EPP has less computation and communication costs.
Profiles of autonomic stress responsivity in a sample of justice‐involved youth: Associations with childhood trauma exposure and emotional and behavioral functioning
Authors: Lin Betty , Kidwell Mallory C. , Kerig Patricia K. , Crowell Sheila E. , Fortuna Anthony J. 
Published: March 2020

AbstractA limited number of studies have begun to investigate how the coordinated actions of distinct physiological systems may be related to the development of psychopathology. However, the form taken by these patterns of coordination as well as their antecedents and developmental implications remain to be clarified. The Adaptive Calibration Model (ACM) proposes four prototypical patterns of physiological stress responsivity and corresponding behavioral patterns, which are further tied to varying levels of childhood adversity. The current study is among the first to investigate whether patterns of sympathetic and parasympathetic stress responsivity predicted by the ACM generalize to a sample of justice‐involved youth with disproportionately high rates of childhood trauma exposure. Psychophysiological and self‐report data were collected from 822 justice‐involved youth (182 girls) ages 12–19 years. Latent profile analyses yielded five profiles of physiological responsivity that largely corresponded to the patterns proposed by the ACM. Further, these profiles demonstrated predicted associations with self‐reported emotionality and adjustment. Trauma exposure was associated with a lower likelihood of membership in one of the profiles showing blunted physiological responsivity. Our discussion highlights ways in which insights from the ACM may inform understanding about linkages between physiology and adjustment.
Do dried blood spots (DBS) have the potential to support result management processes in routine sports drug testing?
Authors: Thevis Mario , Kuuranne Tiia , Dib Josef , Thomas Andreas , Geyer Hans 
Published: March 2020

AbstractDried blood spots (DBS) have been considered as complementary matrix in sports drug testing for many years. Especially concerning substances prohibited in‐competition only, the added value of DBS collected concomitantly with routine doping control urine samples has been debated, and an increasing potential of DBS has been discussed in the scientific literature. To which extent and under which prerequisites DBS can contribute to enhanced anti‐doping efforts is currently evaluated. As a proof‐of‐principle, two analytical applications, one targeting cocaine/benzoyl ecgonine and the other prednisone/prednisolone, are presented in this perspective to indicate potential added value but also presently existing limitations of the DBS approach.
Habitat fragmentation influences genetic diversity and differentiation: Fine‐scale population structure ofCercis canadensis(eastern redbud)
Authors: Ony Meher A. , Nowicki Marcin , Boggess Sarah L. , Klingeman William E. , Zobel John M. , Trigiano Robert N. , Hadziabdic Denita 
Published: March 2020

AbstractForest fragmentation may negatively affect plants through reduced genetic diversity and increased population structure due to habitat isolation, decreased population size, and disturbance of pollen‐seed dispersal mechanisms. However, in the case of tree species, effective pollen‐seed dispersal, mating system, and ecological dynamics may help the species overcome the negative effect of forest fragmentation. A fine‐scale population genetics study can shed light on the postfragmentation genetic diversity and structure of a species. Here, we present the genetic diversity and population structure ofCercis canadensisL. (eastern redbud) wild populations on a fine scale within fragmented areas centered around the borders of Georgia–Tennessee, USA. We hypothesized high genetic diversity among the collections ofC. canadensisdistributed across smaller geographical ranges. Fifteen microsatellite loci were used to genotype 172 individuals from 18 unmanaged and naturally occurring collection sites. Our results indicated presence of population structure, overall high genetic diversity (HE = 0.63,HO = 0.34), and moderate genetic differentiation (FST = 0.14) among the collection sites. Two major genetic clusters within the smaller geographical distribution were revealed by STRUCTURE. Our data suggest that nativeC. canadensispopulations in the fragmented area around the Georgia–Tennessee border were able to maintain high levels of genetic diversity, despite the presence of considerable spatial genetic structure. As habitat isolation may negatively affect gene flow of outcrossing species across time, consequences of habitat fragmentation should be regularly monitored for this and other forest species. This study also has important implications for habitat management efforts and future breeding programs.
Electrocatalytic Investigations of Cu(II) and Fe(III) Complexes of Salophen Derivative Schiff Bases on the Pencil Graphite Electrode
Authors: Cakmak D. , Bulut T. , Uzun D. 
Published: March 2020

AbstractThis present study describes a pencil graphite electrode surface covered with Cu(II) and Fe(III) complexes based on Salophen derivative Schiff bases in acetonitrile solution containing LiClO4 as a supporting electrolyte. Cyclic voltammetry method was used for the surface modification procedure with 25 cycle at a sweep rate of 50 mV s−1. Some characterization methods were used to identify of the prepared modified surfaces including cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), Ultraviolet‐visible Spectroscopy (UV‐Vis), and Scanning Electron Microscopy/Energy Dispersive X‐ray Spectroscopy (SEM/SEM‐EDX). The catalytic activity of these modified surfaces on the electrochemical oxidation of catechol (CC) was investigated and they compared with each other. The results demonstrated that these modified electrodes showed perfect electrocatalytic activity on the catechol determination, however the modified electrode prepared with the Cu(II) complex has higher catalytic activity than this prepared with the Fe(III) complex thanks to its the lower detection limit.