bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adaptasi dan Validasi Alat Ukur Perilaku Inovatif Karyawan
Authors: Rosyiana Iffah , Suhariadi Fendy , Handoyo Seger , Fajrianthi Fajrianthi 
Published: July 2020

The growth of the hotel business is increasing, along with the development of tourism. This condition encourages hoteliers to compete to advance their business with a variety of service innovation processes. Therefore, it is essential to know and identify the innovative behavior of hospitality employees. This study aims to develop innovative employee behavior measurement tools. We used a quantitative study involving 143 sales marketing employees in hospitality as respondents. The sample selection uses a random sampling technique. The development of innovative behavioral questionnaires was revealed through three dimensions, namely the idea generation dimension, idea championing, and idea implementation. Data analysis used confirmatory factor analysis (CFA) with the help of Amos 22 software. The results of the study revealed that the innovative behavior measurement model met the goodness of fit criteria. These findings indicate that innovative behavior can be measured by the dimensions of idea generation, idea championing, and idea implementation. The results of this study also have implications for several hospitality practitioners to evaluate the innovative behavior of hospitality employees. Keywords: innovative behavior, scale adaptation, validity, Confirmatory Factor Analysis
Posługa myślenia wobec współczesnego stanowiska Ecclesia turpis. Refleksja teologiczno-psychologiczna
Authors: Bukalski Sławomir 
Published: July 2020

Jednym z najważniejszych zadań chrześcijanina jest „posługa myślenia”, o której uczył Jan Paweł II. Zwłaszcza w obliczu antychrześcijańskiej propagandy, która narzuca wizję Kościoła odrażającego, szpetnego, brzydkiego – Ecclesia turpis. Pytanie problemowe brzmi: jak ma reagować chrześcijanin wobec tej propagandy, wykorzystując posługę myślenia?Punktem wyjścia w artykule jest analiza papieskiego pojęcia „posługa myślenia” i zagrożenia wynikającego z odrzucenia tej posługi, tj. kształtowania mentalności niewolnika. Kolejny etap to rozpatrzenie współczesnych mechanizmów zohydzania Kościoła przejawiających się w przypisywaniu mu czynów kryminalnych na ogromną skalę oraz wywoływaniu u odbiorców negatywnych emocji. Na końcu przedstawiono stanowisko wobec powyższego procesu, ze szczególnym uwzględnieniem problemu wykorzystywania seksualnego nieletnich przez duchownych. Artykuł ma charakter teologiczno-psychologiczny.
Jak mówić o Bogu w postateistycznym świecie? Analiza myśli Dietricha Bonhoeffera i jej implikacji dla wiary katolickiej
Authors: Laskowska Ewa 
Published: July 2020

Obecne czasy określić można jako erą postateistyczną, w której ludzie nie zadają już pytań o Boga. Po latach wojującego ateizmu nadszedł czas życia w świecie „tak jakby Boga nie było”. Doskonale zdawał sobie z tego sprawę protestancki pastor Dietrich Bonhoeffer, którego myśl jest dziś w środowiskach protestanckich niezwykle popularna. Przedstawił on tezę życia w świecie „etsi Deus non datetur” oraz wysunął postulat chrześcijaństwa bezreligijnego.Artykuł bada, czy koncepcje Bonhoeffera mogą być pomocne również dla teologów katolickich, czy mogą stać się inspiracją w refleksji nad tym, jak mówić o Bogu we współczesnym świecie. Przy próbie odpowiedzi na powyższe pytania pomocna jest analiza dzieł Bonhoeffera.Artykuł wykazuje, że myśl Bonhoeffera może stać się wskazówką dla mówienia o Bogu, gdyż przypomina ważne, często zapominane aspekty chrześcijaństwa. Może także być pomocna dla chrześcijan w podjęciu refleksji nad własną wiarą.
Genomic Alterations of NTRK, POLE, ERBB2, and Microsatellite Instability Status in Chinese Patients with Colorectal Cancer
Authors: Guo Yun , Guo Xian-ling , Wang Shuang , Chen Xinyu , Shi Jiaochun , Wang Jian , Wang Kai , Klempner Samuel J. , Wang Weifeng , Xiao Min 
Published: July 2020

Abstract

Background
The increasing molecular characterization of colorectal cancers (CRCs) has spurred the need to look beyond RAS, BRAF, and microsatellite instability (MSI). Genomic alterations, including ERBB2 amplifications and mutations, POLE mutations, MSI, and NTRK1–3 fusions, have emerged as targets for matched therapies. We sought to study a clinically annotated Chinese cohort of CRC subjected to genomic profiling to explore relative target frequencies.

Methods
Tumor and matched whole blood were collected from 609 Chinese patients with CRC. Extracted DNA was analyzed for all classes of genomic alterations across 450 cancer-related genes, including single-nucleotide variations (SNVs), short and long insertions and deletions (indels), copy number variations, and gene rearrangements. Next-generation sequencing–based computational algorithms also determined tumor mutational burden and MSI status.

Results
Alterations in TP53 (76%), APC (72%), and KRAS (46%) were common in Chinese patients with CRC. For the first time, the prevalence of NTRK gene fusion was observed to be around 7% in the MSI-high CRC cohort. Across the cohort, MSI was found in 9%, ERBB2 amplification in 3%, and POLE pathogenic mutation in 1.5% of patients. Such results mostly parallel frequencies observed in Western patients. However, POLE existed at a higher frequency and was associated with large tumor T-cell infiltration.

Conclusion
Comparing to the Western counterparts, POLE mutations were increased in our cohort. The prevalence of NTRK gene fusion was around 7% in the MSI-high CRC cohort. Increased adoption of molecular profiling in Asian patients is essential for the improvement of therapeutic outcomes.

Implications for Practice
The increasing use of genomic profiling assays in colorectal cancer (CRC) has allowed for the identification of a higher number of patient subsets benefiting from matched therapies. With an increase in the number of therapies, assays simultaneously evaluating all candidate biomarkers are critical. The results of this study provide an early support for the feasibility and utility of genomic profiling in Chinese patients with CRC.
Farklı Dönemlerde Mimaride Kullanılan Cam Binalar ve Yapısal Özellikleri
Authors: SAĞLIYAN SÖNMEZ Özlem , ÇETİN Suna 
Published: July 2020

19. yy’dan günümüze kadar geçen zaman içerisinde, geniş olanak yelpazesine sahip mimari yapılar, cam duvarların da kullanılmasıyla hafif, şeffaf ve havadar görüntülü yapıların gelişmesine olanak sunmuştur. Cam üzerinde yapılan teknolojik çalışmalar ve bunun sonucundaki olumlu gelişmeler mimarlar için camı daha çekici bir malzeme yapmıştır. Özellikle çelik ve camın mimari yapılarda birleşmesi saydamlık ve hafiflik yolunu açarak bu alanda yeni gelişmeler sağlamıştır. Görünen o ki camın gelişmeye açık bir malzeme olduğu gün geçtikçe daha çok kabul edilmekte ve cam mimari artık strüktürel olarak da yer almaktadır. Bir zamanlar bir ütopyadan ibaret olan cam mimarisi günümüzde artık bir gerçek haline gelmiştir. Bu anlamda bu çalışma içerisinde 9 adet mimari yapı ele alınmış ve yapısal olarak incelenerek cam binalara örnek olarak sunulmuştur.
Antioxidant potential of seminal plasma in normozoospermia and asthenozoospermia
Authors: Proskurnina E. V. , Melnikov N. A. , Dolgikh O. A. , Shtaut M. I. , Chernykh V. B. 
Published: July 2020

The study objective is to evaluate the antioxidant potential of seminal plasma in normozoospermia and asthenozoospermia.Materials and methods. Samples of ejaculate from 57 men of reproductive age were studied. Standard spermiologic examination and determination of the antioxidant potential of the seminal fluid using an original chemiluminescent method were performed. The method allowed to measure duration of the latent period from the moment of a decrease in luminescence of the solution containing reactive oxygen species (ROS) after addition of the seminal fluid until the most dramatic increase in luminescence corresponding to decreased antioxidant effect of the seminal fluid.Results. In the samples, the latent time varies from 4.6 to 17.5 minutes. Compared with normozoospermia, the antioxidant potential is significantly lower (p = 0.05) in men with asthenozoospermia (about 1.4 times), and even lower in patients with asthenoteratozoospermia (about 1.7 times) (p = 0.03). An inverse weak correlation was found between the activity of leukocytes and latent time in pathospermia (r = –0.23 and –0.18 for asthenozoospermia и asthenoteratozoospermia, respectively). A direct strong correlation was found between ROS-producing sperm activity and latent time in normozoospermia (p = 0.79), and inverse correlation in pathospermia (r = –0.26 and –0.62 for asthenozoospermia и asthenoteratozoospermia, respectively).Conclusion. Pathospermia is characterized by antioxidant seminal plasma deficiency, more pronounced for asthenoteratozoospermia. The antioxidant system of seminal plasma correlates with the ROS-producing ability of leukocytes and, to a greater extent, of the sperm. With normozoospermia, the oxidative balance is maintained, with pathospermia, a higher value of ROS production by sperm corresponds to a lower value of antioxidant capacity.
Comparison of the effectiveness of medications containing a combination of zinc and arginine for treatment of male infertility
Authors: Zhukov О. B. , Bragina E. E. , Levina A. V. , Evdokimov V. V. , Terushkin R. A. , Akramov M. M. , Shakhov A. S. , Vasilyev A. E. 
Published: July 2020

The study objective is to perform clinical laboratory evaluation of the effectiveness of Prostatilen® AC and Arginine-zinc in treatment of patients with sperm pathology and concomitant varicocele and chronic nonbacterial prostatitis.Materials and methods. The study included 60 patients between 23 and 46 years of age. The first group included 30 patients (15 patients with varicocele and 15 patients with chronic nonbacterial prostatitis) who received Prostatilen® AC. The second group included 30 patients (15 patients with varicocele and 15 patients with chronic nonbacterial prostatitis) who received Arginine-zinc. Therapy duration was 20 days. Standard clinical and laboratory examination, spermiologic examination as well as measurement of antisperm antibodies, DNA fragmentation, oxidative stress level, cryotest, electron microscopy examination of the ejaculate were performed.Results. Five (5) days after the end of therapy, percentage of progressive motile sperm increased by 62 % in the Prostatilen® AC patient group with chronic nonbacterial prostatitis (р <0.001) compared to the baseline, and by only 10 % in the Arginine-zinc patient group. Administration of Prostatilen® AC lead to a more significant decrease of reactive oxygen intermediates in the ejaculate (р <0.001) and percentage of sperm with fragmented DNA (р <0.001) compared to administration of Arginine-zinc. The applied treatment schemes had no significant effect on the number of sperm with acrosomal hypoplasia. An anti-inflammatory effect of Prostatilen® AC was also identified (decreased number of leukocytes in sperm). During the study, 3 cases of adverse effects were registered: 1 after administration of Prostatilen® AC and 2 after administration of Arginine-zinc.Conclusion. Prostatilen® AC can be considered more effective and safer compared to Arginine-zinc for 20-day administration. In patients with sperm pathology, it more effectively improves sperm characteristics: increases sperm motility, sperm morphology, decreases DNA fragmentation and oxidative stress levels.
Obesity as a factor in spermatogenesis disorders (experimental study)
Authors: Artamonov A. A. , Bogolyubov S. V. , Eliseeva T. I. , Pozdnyakov O. B. , Astakhova A. V. 
Published: July 2020

Introduction. In recent years, the effects of obesity on male fertility have been extensively investigated. The results of existing studies are extremely contradictory.The study objective was to determine the effect of obesity on the male reproductive system using the biological model of laboratory rats as an example.Materials and methods. In vivo modeling of diet-induced obesity. The study was conducted on 22 laboratory sexually mature white rats weighing 140–160 g. The animals were divided into two groups: 1 control (10 animals) and 2 rats with diet-induced obesity (12 animals). After 12 weeks, the animals were removed from the experiment. All rats underwent: calculation of the Lee index (body mass index in rats), determination of the concentration and viability of spermatozoa in a suspension of sperm from the epididymis, determination of glucose level of total cholesterol and triglycerides in the blood, study of sperm DNA fragmentation, histological examination testis: calculating the crosssectional area of the seminiferous tubule; determination of the number of non-functioning tubules and tubules with desquamated spermiogenic epithelium; determination of the average spermatogenesis index.Results. In the study groups there were no differences in glucose and total cholesterol levels. However, a statistically significant, significant difference in the level of triglycerides in the blood was revealed. The concentration of sperm and their viability in the studied groups did not differ. The level of sperm DNA fragmentation in the experimental group is significantly higher than in the control group (31.5 ± 10.1 and ± 1.4 %, respectively, p <0.05). Morphometric evaluation of histological preparations did not establish differences in the cross-sectional area of the seminiferous tubules and the average spermatogenesis index in the studied groups. In rats with obesity, compared with the control group, significantly more non-functioning tubules (2.9 ± 0.3 and 8.4 ± 0.3; p <0.05) and tubules with desquamated spermatogenic epithelium (1.8 ± 0.3 and 8.8 ± 0.5; p <0.05).Conclusion. Diet-induced obesity causes impaired spermatogenesis, and damage to the sperm genetic material in male white rats.
Reno-iliac intrasystem anastomoses of the inferior vena cava
Authors: Kapto A. A. 
Published: July 2020

The study objective is to describe the anastomoses between the left renal and iliac veins in the inferior vena cava system and to classify these anastomoses.Materials and methods. From 2015 to 2020, 340 men with varicose veins of the pelvic organs and bilateral varicocele were examined. Delayed imaging for 10–30 s with phlebotesticulography of 157 patients allowed us to study in more detail the vascular venous x-ray anatomy of the scrotum and various options for collateral circulation.Results. The data obtained by us during phlebography allowed us to offer our own classification of anastomoses between the left renal vein and the common iliac vein in the inferior vena cava system (reno-iliac intrasystemic anastomoses of the inferior vena cava): 1) through the vein of the vas deferens (v. ductus deferens), 2) through the cremasteric vein (v. cremasterica), 3) through the external testicular vein (v. testicularis externa). In addition to the classification, the terms for specific types of anastomoses are also proposed by us for the first time and do not have a name in the medical scientific literature. A new definition of the term “venous anastomotic node (nodus venarum anastomoticus) of the testis and its appendage” is proposed, which describes the anatomical relationship between the 4 veins: the internal testicular vein, external testicular vein, vena cremasterica and veins of the vas deferens. A new term is proposed “pseudo-varicocele” that defines the compensatory expansion of the internal testicular vein during normal antegrade blood flow through it.Conclusion. In this work, we give an X-ray anatomical description of the development of various types of collateral circulation in the system of the inferior vena cava between the left renal vein and iliac vessels in various types of arteriovenous conflicts of both the upper (nutcracker syndrome, posterior nutcracker syndrome) and the lower level (May–Thurner syndrome).
Micronutrient deficiency in men with infertility
Authors: Tsukanov A. Yu. , Turchaninov D. V. , Satybaldin D. A. , Yunatskaya T. A. , Sokolov K. N. 
Published: July 2020

The study objective is to compare the level of micronutrients in men with infertility and men with normal fertility. Materials and methods. The levels of А, В9, D, Е, С vitamins in blood using high-performance liquid chromatography and selenium and zinc in hair using atomic absorption mass-spectrometry were measured in men with diagnosis of male idiopathic infertility (n = 82) and men with normal fertility (n = 93).Conclusion. Absence of a total lack of micronutrient deficiency in men with infertility was observed. Presumably, azoospermia can be associated with deficiency in some micronutrients casting doubt on the necessity of administration of multicomponent vitamin and mineral complexes.Results. Blood levels of А, D and В9 vitamins did not significantly differ in the studied groups, while differences in blood levels of С and Е vitamins and selenium and zinc in hair were statistically significant. While the levels of А, Е, В9 vitamins, selenium and zinc were in the reference ranges, vitamin C deficiency was observed in the test group and vitamin D deficiency in both groups. Higher level of selenium in the test group presumably reflects its higher metabolism due to higher influx of xenobiotics in the organism and indicates pre-deficiency state.
Experience in post-traumatic venous malformation of urethra spongy body treatment
Authors: Demin N. V. , Ladygina Е. A. , Kadyrov Z. A. 
Published: July 2020

The study objective is to present a clinical observation of a 17-year-old boy with post-traumatic venous malformation of the spongy urethra. Clinical case. The patient was hospitalized in an urgent order with complaints of urethrorrhagia. Medical history showed that the first episode of urethrorrhagia happened at 3 years of age and could be caused by a self-injury of the urethra due to mentally traumatic events in the family. After catheterization of the bladder, urethral bleeding stopped, but in the early morning blood seeped past the catheter. Urethroscopy showed an area of modified urethra distally from the penoscrotal junction in the form of pockets with partitions of scar tissue 3 × 1 cm in size that we considered a post-traumatic abnormality. Ultrasound of the corpus spongiosum and magnetic resonance imaging of the genitals didn’t provide additional information. Repeat urethroscopy performed during erection allowed to visualize pathologically dilated vessels bulging into the urethral lumen which were the source of bleeding. Spongiosography allowed to visualize a pathological vascular tree. Diagnosis of post-traumatic venous malformation of the spongy urethra was made. The pathological area was resected with preservation of the fibrous tunic of the corpus spongiosum. The defect was substituted by a flap of the inner preputial leaf. Follow-up observation lasted for 1 year with no urethrorrhagia episodes, the patient didn’t experience any discomfort during sex or micturition.Conclusion. Due to the rarity of this pathology and complexity of diagnosis, the whole spectrum of diagnostic methods should be applied, with urethrocystoscopy and spongiosography being the most informative. Selection of treatment method depends on many factors. If the malformation is located near the urethra, electrocoagulation and angioembolization are ineffective. Resection of the venous malformation within normal tissue and substitution urethroplasty with preputial flap allowed to achieve good clinical and functional result.
L’Utilisation des Comptines dans L’Apprentissage Précoce d’Une Langue Étrangère: Exemples d’Exploitation
Authors: YILMAZ GÜNGÖR Zühre 
Published: July 2020

De nos jours, nombreuses études affirment la nécessité de l’apprentissage précoce des	langues étrangères. Par le biais d’un enseignement d’une langue dès l’âge précoce développe	l’agilité et la flexibilité de la pensée, la capacité d’écoute, l’interaction sociale et la confiance en	soi chez l’enfant. En plus, cela favorise la sensibilité culturelle chez les enfants. L’intérêt de cette	étude théorique est de donner des informations sur les comptines qui s’utilisent souvent dans le	cadre de l’enseignement des langues étrangères aux enfants. Dans ce travail, d’abord, nous	abordons l’apprentissage précoce d’une langue étrangère et l’utilisation des comptines dans les	classes de langue. Ensuite, nous citons brièvement les caractéristiques et les types des comptines	ainsi que leurs rôles dans l’apprentissage de la langue étrangère. Enfin, pour donner une idée aux	chercheurs et aux enseignants de la langue étrangère qui s’intéressent aux comptines et désirent	les utiliser en salle de classe dans le but de motiver leurs apprenants, nous mettons à leur	disposition un exemple d’exploitation à utiliser avec les enfants ainsi que les adultes apprenant le	français comme la langue étrangère. La première comptine s’adresse aux enfants à partir de 7 ans	et qui savent lire et écrire. La deuxième comptine est convenable pour les enfants (5 ou 6ans)	illettrés.
Occurrence of dermatophytes and other fungal agents from clinically suspected cases of superficial mycoses
Authors: Farooq Umar , Altaf Anas , Singh Sudhir , R Sharma Shweta , Sharma Vasundhara 
Published: July 2020

Dermatophytes are group of fungi that infect keratinized tissue. The group consist of three different genera i.e., and , which are distributed around the world. Therefore, the infection of Tinea (dermatophytosis) are one of the most common superficial infections worldwide. Dermatophytes may lead to acute or chronic diseases with high morbidity but not mortality. The main objective of this study was to determine the occurrence of dermatophytosis, isolate and identify the dermatophyte from samples of clinically suspected cases. A total of 220 patients showing lesions typical of dermatophytes infection from outpatient Department of Dermatology were send to Mycology Unit , Department of Microbiology for the period of December 2018 to September 2019 were studied. Diagnosis was confirmed by conventional methods like microscopic, macroscopic examination and culture. Out of 220 KOH mount 61 (27.72%) were found positive. Culture on SDA there were SDA 61 (27.72%) culture positive, 59 (26.81%) DTM culture positive and isolated spp were 39 (17.72%) and 20 (9.06%). Dermatophytosis are distributed worldwide with the increased incidence especially in a tropical country like India. Several factors such as age, sex, illiteracy, poor hygiene, and social economy influence the dermatophyte infection. This study shows that the epidemiological status of the dermatophytes. Tinea corporis (48.65%) was predominant fungal infection in which dermatophytes were isolated. and have been major etiological agents.