bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plasma calcitonin gene-related peptide and nitric oxide predict therapeutic response to amlodipine in pediatric primary hypertension
Authors: Wang Hui , Lin Yao , Wang Yuting , Shen Chen , Li Yaqi , Liu Yang , Shi Lin 
Published: December 2024

BackgroundThere is a lack of suitable predictive markers for assessing the efficacy of amlodipine in treating children with primary hypertension. This study aimed to explore whether plasma calcitonin gene-related peptide (CGRP) and nitric oxide (NO) could predict the effectiveness of amlodipine in pediatric primary hypertension.MethodsThis study enrolled 74 children and adolescents with primary hypertension who were prescribed amlodipine monotherapy, and after 4 weeks of treatment, they were divided into responders and non-responders according to blood pressure. Baseline data differences between the two groups were analyzed, followed by binary logistic regression to assess the correlation between significant variables and therapeutic efficacy. The receiver operating characteristic curve was used to evaluate the predictive efficacy, and the nomogram model was established to predict therapeutic response to amlodipine.ResultsThe responders exhibited lower body mass index, C-peptide and plasma CGRP levels, and higher NO levels compared to the non-responders (p &lt; 0.05). Multivariable logistic analysis revealed that plasma CGRP and NO were independently associated with the therapeutic response to amlodipine, showing a higher predictive performance when used in combination (AUC: 0.814, 95% CI 0.714–0.914) with a predictive sensitivity of 86.5% and specificity of 70.1%. The nomogram model displayed good calibration, and the decision curve analysis indicated this model led to net benefits in a wide range of threshold probability.ConclusionCGRP and NO may be valuable biomarkers for predicting amlodipine effectiveness in the treatment of pediatric primary hypertension, while the nomogram model indicates excellent predictive value.
The impact of eccentric training on athlete movement speed: a systematic review
Authors: Zhang Yugang , Zhuang Yuan , Zhang Lei , Sun Min 
Published: December 2024

Eccentric training has been proposed as a potential method for enhancing athletes' movement speed. However, a systematic review specifically examining the impact of eccentric training on movement speed in athletes has yet to be conducted. This paper aims to fill this gap by evaluating the effects of eccentric training on movement speed in athletes.A systematic search was carried out on May 15, 2024, in accordance with the PRISMA guidelines for systematic reviews and meta-analyses. The search was conducted across multiple databases, including Web of Science, EBSCOhost, PubMed, CNKI, and VIP, using keywords related to eccentric training, athletes, and movement speed. Out of 421 reviews screened, nine met the inclusion criteria. The quality of the studies was assessed using the PEDro scale, with an average score of 3.67 (range 3–4). The results indicated that short-distance sprint speed (n = 7) was the most affected by eccentric training interventions. Sport-specific movement speed (n = 3) and change of direction speed (COD) (n = 5) were also positively influenced, although to a lesser extent.In conclusion, eccentric training significantly enhances sport-specific movement speed and COD speed, with more moderate effects on short-distance sprinting. These findings suggest that eccentric training can be a valuable intervention for improving movement speed in athletes, especially for sports that involve rapid directional changes.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024547112, identifier CRD42024547112.
Theory of mind in schizophrenia through a clinical liability approach: a sib-pair study
Authors: Giralt-López M. , Miret S. , Campanera S. , Moreira M. , Sotero-Moreno A. , Krebs MO. , Fañanás L. , Fatjó-Vilas M. 
Published: December 2024

BackgroundConsistent findings indicate that Theory of Mind (ToM) is impaired in schizophrenia (SZ). To investigate whether such deficits are trait- or state-dependent, we investigated if ToM is modified by clinical liability markers (such as basic symptoms and psychotic-like experiences), focusing on the analysis of unaffected siblings of individuals diagnosed with SZ.MethodsThe study included a total of 65 participants: 38 patients diagnosed with a schizophrenia-spectrum disorder and 27 healthy siblings. ToM was assessed using the Hinting Task (HT), Basic symptoms with The Frankfurt Complaint Questionnaire (FCQ), Psychotic-like-experiences with the Community Assessment of Psychic Experiences (CAPE) and Family history with the Family Interview for Genetic Studies.ResultsFirst, a comparison of HT performance between patients and siblings (linear mixed model adjusted for age, sex and Intelligence Quotient (IQ)) showed that patients presented lower scores than siblings (p = 0.022). These differences did not remain significant after adjusting for clinical vulnerability markers. Second, within siblings, linear regression analyses (adjusted for age, sex, IQ and family history) showed that higher FCQ Depressiveness and CAPE negative scores were related to poorer ToM performance (p = 0.007 and p = 0.032, respectively).ConclusionOur findings suggest that clinical liability markers are valuable for delineating variations in ToM capabilities within healthy individuals. Moreover, our results indicate that ToM deficits are not solely linked to SZ but also extend to its clinical vulnerability, suggesting that ToM could serve as an endophenotypic marker. This implies that ToM could help distinguish particularly susceptible individuals from a population at risk, such as those with a genetic predisposition (siblings).
Voice of a woman: influence of interaction partner characteristics on cycle dependent vocal changes in women
Authors: Lobmaier Janek S. , Klatt Wilhelm K. , Schweinberger Stefan R. 
Published: December 2024

IntroductionResearch has shown that women’s vocal characteristics change during the menstrual cycle. Further, evidence suggests that individuals alter their voices depending on the context, such as when speaking to a highly attractive person, or a person with a different social status. The present study aimed at investigating the degree to which women’s voices change depending on the vocal characteristics of the interaction partner, and how any such changes are modulated by the woman’s current menstrual cycle phase.MethodsForty-two naturally cycling women were recorded once during the late follicular phase (high fertility) and once during the luteal phase (low fertility) while reproducing utterances of men and women who were previously assessed to have either attractive or unattractive voices.ResultsPhonetic analyses revealed that women’s voices in response to speakers changed depending on their menstrual cycle phase (F0 variation, maximum F0, Centre of gravity) and depending on the stimulus speaker’s vocal attractiveness (HNR, Formants 1–3, Centre of gravity), and sex (Formant 2). Also, the vocal characteristics differed when reproducing spoken sentences of the stimulus speakers compared to when they read out written sentences (minimum F0, Formants 2–4).DiscussionThese results provide further evidence that women alter their voice depending on the vocal characteristics of the interaction partner and that these changes are modulated by the menstrual cycle phase. Specifically, the present findings suggest that cyclic shifts on women’s voices may occur only in social contexts (i.e., when a putative interaction partner is involved).
Health behavior and medical insurance under the healthy China strategy: a moral hazard perspective
Authors: Chen Linhong , Zhang Lingyu , Xu Xiaocang 
Published: December 2024

IntroductionHigh medical expenditure is one of the major obstacles to achieving common prosperity in China. As a health risk compensation and protection mechanism, medical insurance has played a good role in alleviating the economic burden of patients. However, due to the existence of moral hazard, medical insurance may also lead to the occurrence of psychological deviation and overtreatment of patients or hospitals’ health treatment expectations, thus generating unnecessary pressure on public financial expenditure.MethodsUsing the China Health and Retirement Longitudinal Survey (CHARLS) and Heckman model, this paper discusses the difference in the impact of medical insurance on outpatient and hospitalization costs. The change of the proportion of out-of-pocket medical expenditure is further analyzed.ResultsThe study found that while medical insurance reduced the probability of outpatient visits and increased the probability of hospitalization, it increased the cost of outpatient visits and hospitalization. Further, it reduces the share of out-of-pocket medical expenditure.DiscussionThis shows that medical insurance does play a role in alleviating the financial pressure of patients, but the overtreatment caused by moral hazard cannot be ignored, especially the over-examination and over-prescribing of drugs in the outpatient process.
Implementation and evaluation of whole-course-based Internet Hospital Outpatient Pharmacy Services: a cross-sectional study in western China
Authors: Gao Yangyang , Lv You , Wang Shiyan , Guo Mengran , Guo Yi , Zheng Minglin , He Lulu , Wu Fengbo , Fan Ping 
Published: December 2024

BackgroundIn recent years, the development of telemedicine and eHealth services has led to the rapid worldwide growth of Internet hospitals, which played a significant role during the coronavirus disease 2019 (COVID-19) pandemic. However, little is known about the characteristics and safety of Internet hospital outpatient pharmacy services (IHOPSs), which represent a new model of pharmaceutical services.ObjectiveThis study aimed to reveal the comprehensive characteristics and safety of whole-course-based IHOPSs in a general tertiary hospital in western China.MethodsWe established a whole-course–based IHOPS model. A total of 373,936 online prescriptions placed from February 1, 2020 to January 31, 2023 were analyzed. These included information on patients, prescriptions, and deliveries; error rates for prescription reviews and medication dispensations; economic value; and degree of patient satisfaction. Over the course of the study, a total of 373,936 prescriptions representing 351,884 patients and 945,172 medications were delivered to 22 provinces, 5 autonomous regions, and 4 municipalities in China.ResultsIHOPSs saved patients more than 320,376 days (7,689,036 h) and RMB (Renminbi) ¥94.05 million in costs. The error rates of prescription review and dispensing were 0.0011% and 0.0008%, respectively. The infectious disease department (n = 63,903; 17.09%) ranked first in the number of prescriptions written for all three consecutive years. Of the 373,936 delivered prescriptions, 90.15% (337,104/373,936) were sent to Sichuan.ConclusionThe IHOPS was found to be efficient, convenient, and safe because it handled the challenge of precisely and safely delivering medications to patients on time during and to the end of the COVID-19 pandemic. It provided patients with safe and convenient pharmaceutical services unlimited by geography or time zones. Widespread use of this service could help alleviate pressure on offline pharmacists, giving them the time and resources to provide other professional services. Our model can therefore serve as a useful reference for policymakers to support the development of Internet pharmaceutical services. Further efforts are needed to regulate and standardize the management of this novel service.
The factors associated with teenage pregnancy among young women aged between 15 and 19 years in Rwanda: a retrospective cross-sectional study on the Rwanda Demographic Health Survey 2019–2020
Authors: Nduhuye Felix , Kubana Emmanuel , Matutina Stella , Mwesigye David , Munyaneza Athanase , Nyirazinyoye Laetitia 
Published: December 2024

BackgroundTeenage pregnancy is a significant public health issue and is strongly associated with risky sexual behaviors such as early sexual initiation, unprotected sex, and multiple sexual partners. According to the 2014 World Health Organization report, 11% of all births worldwide were to teenagers aged 15–19 years, with more than 95% of these pregnancies occurring in low- and middle-income countries, particularly in sub-Saharan Africa, which bears much of this burden. In Rwanda, the prevalence of teenage pregnancy has risen from 4.1% in 2005 to 7.3% in 2014, indicating a growing concern. However, there is limited and inconsistent evidence on the factors contributing to teenage pregnancy. Hence, our study aimed to investigate the factors associated with teenage pregnancy. This research seeks to provide valuable insights for targeted interventions, which are urgently needed in light of the increasing rates.MethodsWe employed a cross-sectional study design, utilizing data from the 2019/2020 Rwanda Demographic Health Survey of 3,258 eligible participants aged 15–19 years. To identify factors associated with teenage pregnancy, we performed a bivariate logistic regression analysis. The significant variables from the bivariate analysis were then exported into multivariate logistic regression models, with the results presented as odds ratios (ORs) along with 95% confidence intervals (CIs) and a significance threshold set at 5%.ResultsOur findings indicated that teenagers aged 18–19 years were more likely to experience pregnancy compared to those younger than 17 (OR = 4.2; 95% CI: 2.16–8.37). Adolescents who had engaged in sexual activity 95 times or more had a significantly higher likelihood of becoming pregnant than those with less frequent sexual activity (OR = 13.53; 95% CI: 5.21–35.12). Furthermore, adolescents with parents with a secondary education were 80% less likely to become pregnant compared to those with parents with a primary or no education (OR = 0.2; 95% CI: 0.07–0.63).ConclusionOur study revealed that teenage pregnancy is shaped by several individual factors including age and sexual behavior, along with parental education levels. These findings underscore the critical need for targeted sexual education and enhanced family support systems to mitigate teenage pregnancies. Further, longitudinal studies are essential for establishing causality and guiding effective policy development.
Response of infrared thermography related parameters to (non-)sport specific exercise and relationship with internal load parameters in individual and team sport athletes—a systematic review
Authors: Masur Lukas , Brand Florian , Düking Peter 
Published: December 2024

IntroductionMonitoring internal load is crucial for athletes but often requires invasive methods for muscle-related parameters, limiting practicality. Infrared thermography (IRT) related parameters might overcome this limitation. This systematic review aimed to examine the available literature on the response of IRT related parameters to (non-)sport specific exercise and reveal relationships with internal load parameters in athletic populations.MethodsFour scientific databases were systematically searched (February 2024) with keywords related to IRT, load, and sports disciplines. Risk of bias was evaluated using QUADAS-2. Main inclusion criteria for studies were i) reporting of IRT related parameters and other internal load parameters prior/post (non-)sport specific exercise ii) inclusion of least Tier 2 athletes ≥ 18 years. After identifying n = 10,538 studies, 13 articles (n = 231 participants) were included.ResultsFollowing (non-)sport specific exercise in athletic populations, the majority of relevant studies showed a decrease in IRT related parameters within 15 min, while studies showed an increase in IRT related parameters following 30 min, 24 h, 48 h, and 72 h after exercise cessation. Relationships between alterations in IRT related parameters and other internal load parameters are inconsistent across the literature.ConclusionWhile the majority of studies show an increase in IRT related parameters following (non-)sport specific exercise, relationships with other internal load parameters and underlying physiological mechanisms evoking IRT related alterations are not conclusively revealed in athletic populations. Future research needs to assess the relationship of IRT related parameters especially with inflammatory parameters in athletic populations following (non-)sport specific exercise. Practitioners might assess IRT related parameters in conjunction with other load parameters.
Case Report: Life-saving embolization: a rare case of post-traumatic retroperitoneal hematoma from deep circumflex iliac artery rupture
Authors: Xu Hong-wei , He Cong 
Published: December 2024

IntroductionRetroperitoneal hematoma with ongoing hemorrhage is a rare but critical condition following blunt abdominal trauma, requiring urgent evaluation and management. This case details a large retroperitoneal hematoma in the right iliac fossa caused by a rupture of the deep circumflex iliac artery (DCIA), successfully treated with transcatheter arterial embolization.Case descriptionA 66-year-old female presented to our hospital six hours after an electric tricycle accident with dizziness, fatigue, hypotension (80/50 mmHg), and tachycardia (105 beats/min). Laboratory tests revealed a hemoglobin level of 9.2 g/dl and a hematocrit level of 27.5%. Contrast-enhanced CT showed an 18 cm × 10 cm × 5 cm retroperitoneal hematoma in the right iliac fossa with active bleeding. Emergent angiography identified the bleeding source as a branch of the right DCIA. Embolization was performed using a microcoil through a coaxial microcatheter positioned proximal to the bleeding site, successfully stopping the hemorrhage. The patient's condition stabilized, and ultrasound monitoring showed a gradual reduction in hematoma size. The patient was discharged two weeks later.ConclusionThis case highlights a rare but severe instance of retroperitoneal hematoma due to DCIA rupture, effectively managed with transcatheter arterial embolization. The utility of contrast-enhanced CT and angiography in diagnosing active bleeding is emphasized, underscoring the efficacy of transcatheter embolization as a critical intervention in such life-threatening situations.
Initial investigation into patellofemoral morphology in hemophilic arthritis patients
Authors: Wang Haohao , Jiang Rendong , Dong Zhishang , Zhao Dongyue , Zhao Jianli , Shi Chao , Yuan Zhen 
Published: December 2024

BackgroundHemophilic arthritis (HA) is associated with significant changes in the morphology of mature knee joints due to abnormal growth plate development. Previous studies have established marked distinctions between the femur and tibia of subjects with Haemophilia and those with osteoarthritis (OA). This study explored the morphological characteristics of the patella and patellofemoral joint in subjects with Haemophilia. These findings can inform the design of knee joint prostheses tailored to this condition, improve the precision of total knee replacement surgery, and reduce postoperative knee pain and patellar dislocation.MethodsBefore surgery, we conducted preoperative measurements of patellar length, patellar diagonal length, patellar ligament length, patellar width, patellar thickness, the INSALL index, the lateral patellofemoral angle, the trochlear groove angle,the patellar lateral displacement rate, and the patellofemoral index using lateral and axial x-ray images in 40 subjects with Haemophilia, 40 OA patients, and 40 normal individuals.ResultsSignificant statistical differences in certain morphological parameters were observed among the three groups of patients (P &lt; 0.05). Compared with the OA and normal control groups, the HA group presented significant disparities in patellar thickness, patellar ligament length, the Insall ratio, the patellar lateral shift rate, the lateral patellar angle, and the patellofemoral index.ConclusionCompared with OA and normal individuals, Subjects with Haemophilia presented with smaller and thinner patellae, more significant patellar ligament contracture, reduced patellar height, and more pronounced patellar dislocation. Consequently, during total knee arthroplasty, we lean toward patellar reshaping in subjects with Haemophilia, exercise caution when considering patellar replacement, and, for those with severe preoperative patellar dislocation, perform intraoperative lateral retinacular release.
Recombinant characteristics and pathogenicity of a novel PRRSV variant in weaned piglets derived from recombination of three clinical epidemic strains
Authors: Yang Yalin , Yao Longshuai , Wang Xinyuan , Dong Xinrong , Wang Gang , Yu Ying 
Published: December 2024

IntroductionThe recent emergence of PRRSV strains NADC30 and NADC34, along with their recombination with HP-PRRSV-like strains, has added complexity to PRRS control strategies on swine farms. Given the high variability and recombination potential of PRRSV, continuous monitoring of the virus’s clinical epidemiology is essential for effective prevention and control.MethodsThis study isolated a PRRSV variant, designated SDVD-NMG2023, from approximately 65-day-old pigs, showing a mortality rate of around 15% within the herd. The whole-genome, ORF5, and NSP2 sequences of the SDVD-NMG2023 isolate were aligned with 42 reference strains using MEGA software. Recombination analysis was performed using SimPlot software and RDP software. Pathogenicity analysis of SDVD-NMG2023 was conducted in four-week-old SPF Yorkshire piglets.ResultsPhylogenetic and molecular evolutionary analyses revealed a natural recombination event involving the NADC30, NADC34, and JXA1 strains. Piglets infected with SDVD-NMG2023 exhibited mild clinical symptoms, including elevated rectal temperatures in two out of five piglets, as well as cough, mild anorexia, weight stunting, interstitial pneumonia, and thymic atrophy in all cases.DiscussionThe findings indicate that the novel crossbred PRRSV isolate SDVD-NMG2023, derived from three prevalent clinical strains, may induce more unusual clinical presentations compared to those associated with HP-PRRS, albeit still impacting the health of the herd by causing immunosuppression. This study provides critical insights into the emergence of multi-strain PRRSV recombination, particularly between NADC30/34-like and HP-PRRSV-like strains, supporting a more strategic and comprehensive approach to PRRS prevention and control.