bluuebunny/crossref_metadata_2025_split huggingface dataset:
A New Day: The Role of Telemedicine in Reshaping Care for Persons With Movement Disorders
Authors: Dorsey E. Ray , Bloem Bastiaan R. , Okun Michael S. 
Published: September 2020

ABSTRACTThe COVID‐19 pandemic has demonstrated the fragility of clinic‐based care for Parkinson's disease and other movement disorders. In response to the virus, many clinics across the world abruptly closed their doors to persons with Parkinson's disease. Fortunately, a niche care model, telemedicine—first described in this journal a generation ago—emerged as the dominant means of providing care. As we adjust to a new normal, we should focus future care not on clinics but on patients. Their needs, guided by clinicians, should determine how care is delivered, whether in the clinic, at home, remotely, or by some combination. Within this patient‐centered approach, telemedicine is an attractive care option but not a complete replacement for in‐person consultations, which are valuable for specific problems and for those who have access. Now that many clinicians and patients have gained exposure to telemedicine, we can better appreciate its advantages (eg, convenience) and disadvantages (eg, restricted examination). We can also create a new future that utilizes the Internet, video conferencing, smartphones, and sensors. This future will bring many clinicians to one patient, connect individual experts to countless patients, use widely available devices to facilitate diagnosis, and apply novel technologies to measure the disease in new ways. These approaches, which extend to education and research, enable a future where we can care for anyone anywhere and will help us stem the tide of Parkinson's disease. © 2020 International Parkinson and Movement Disorder Society
Genetic variants in GHR and PLCE1 genes are associated with susceptibility to esophageal cancer
Authors: Wang Rong , Si Lining , Zhu Derui , Shen Guoping , Long Qifu , Zhao Yanli 
Published: September 2020

AbstractBackgroundEsophageal cancer (EC) is the leading cause of cancer‐related mortality worldwide. The underlying genetic risk factors remain unclear. The association between gene growth hormone receptor (GHR) and phospholipase C epsilon 1 (PLCE1) polymorphisms and the EC risk were identified in this study.MethodsA total of 506 EC cases and 507 controls were included in this research. Two SNPs (rs6898743 of GHR and rs2274223 of PLCE1) were selected and genotyped. The associations between gene polymorphisms and the EC risk were assessed by logistic regression analysis. The databases RegulomeDB, GTEx, and UALCAN were used for functional annotations.ResultsIn the allelic frequencies analysis, the rs6898743 of GHR was associated with decreased susceptibility of EC (OR = 0.83, 95% CI: 0.70–1.00, p = 0.049), while rs2274223 of PLCE1 was associated with increased 0.25‐fold EC risk (OR = 1.25, 95% CI: 1.02–1.53, p = 0.037). The “GC” genotype of rs6898743 was associated with a 0.24‐fold decreased risk of EC under co‐dominant model (OR = 0.76, 95% CI: 0.58–0.99, p = 0.046), and the “GA” genotype of rs2274223 was associated with increased EC risk under co‐dominant model (OR = 1.36, 95% CI: 1.04–1.77, p = 0.023). Using GTEx database, rs2274223 was found to be significant associated with increased PLCE1 expression (p = 4.1 × 10−7) in esophagus muscularis. The UALCAN database demonstrated that the GHR gene was under‐expressed in esophageal cancer tissues (p = 0.017).ConclusionThe gene GHR and PLCE1 polymorphisms are associated with EC in the general population and the results need to be verified in future.
Fecundity is impaired in a mouse model of osteogenesis imperfecta
Authors: Oestreich Arin K. , DeCata Jenna A. , Akers Janae D. , Phillips Charlotte L. , Schulz Laura. C. 
Published: September 2020

AbstractOsteogenesis imperfecta (OI), or brittle bone disease, is most often caused by mutations in genes encoding type I collagen or proteins that process it. Women with OI have a small, but significant increase in risk of serious pregnancy complications including uterine rupture. Here, the OI mouse, Col1a2oim/oim, was used to examine the effects of collagen mutation on establishment and maintenance of pregnancy. Picrosirius birefringence was faint in Col1a2oim/oim uteri, indicating diminished collagen in the myometrium and endometrium. There was some evidence of increased uterine gland number (p = .055) and size (p = .12) in (p = .055) virgin uteri, though the they were not significantly different than controls. There were no differences in the number of corpora lutea, or the time from pairing to delivery of pups between Col1a2oim/oim and control dams, suggesting that ovulation and conception occur normally. However, when examined at Gestation Day 6.5 (postimplantation), gestation Day 10.5 (midpregnancy), and Postnatal Days 1–2, Col1a2oim/oim dams had significantly fewer viable pups than controls overall. In pairwise comparisons, the loss was only significant in the postnatal group, suggesting the gradual loss of pups over time. Overall, the Col1a2oim/oim mouse data suggest that OI impairs uterine function in pregnancy in a way that affects a small but significant number of fetuses.
A long‐lasting biological larvicide against the dengue vector mosquito Aedes albopictus
Authors: Liu Tong , Xie Yu‐Gu , Lin Feng , Xie Li‐Hua , Yang Wen‐Qiang , Su Xing‐Hua , Ou Chun‐Quan , Luo Lei , Xiao Qi , Gan Lu , Chen Xiao‐Guang 
Published: September 2020

AbstractBACKGROUNDAedes albopictus is the primary vector of mosquito‐borne diseases, including dengue and chikungunya, in China. The management of vector mosquitoes is the primary strategy for the control of such infectious diseases. The gravid Ae. albopictus prefers to skip‐oviposit its eggs into different small water containers, and the management of these breeding places is critical for mosquito control. Bacillus thuringiensis subspecies Israelensis (Bti) is a useful biological larvicide, but the effective period of the currently available commercial product is relatively short. This study aimed to develop a long‐lasting formulation of Bti to control the dengue vector mosquito Ae. albopictus.RESULTSWater‐soluble polyethylene glycols and water‐insoluble hexadecanol were mixed with Bti to develop the long‐lasting formulation Bti‐BLOCK, based on the solid dispersion technique. The controlled release of Bti‐BLOCK and its effect on Ae. albopictus were assayed in the laboratory and in the field. The results showed that Bti toxins were slowly released from Bti‐BLOCK into the water and maintained at an effective dose for at least 6 months. Bti‐BLOCK caused high mortality during the immature stage (>90%) and achieved full inhibition during pupation (100%). The efficacy lasted at least 12 weeks in the laboratory and 6 weeks in the field. Furthermore, we confirmed an 89% reduction in Ae. albopictus density and a reduction in the R0 of dengue to a low‐risk level after 6 months of open‐field interventions.CONCLUSIONSWe developed a long‐lasting biological larvicide, Bti‐BLOCK, which displayed very good efficacy in the control of the dengue vector mosquito Ae. albopictus.
A pragmatic adaptive enrichment design for selecting the right target population for cancer immunotherapies
Authors: Nguyen Duc Anh , Heinzmann Dominik , Berge Claude , Wolbers Marcel 
Published: September 2020

SummaryOne of the challenges in the design of confirmatory trials is to deal with uncertainties regarding the optimal target population for a novel drug. Adaptive enrichment designs (AED) which allow for a data‐driven selection of one or more prespecified biomarker subpopulations at an interim analysis have been proposed in this setting but practical case studies of AEDs are still relatively rare. We present the design of an AED with a binary endpoint in the highly dynamic setting of cancer immunotherapy. The trial was initiated as a conventional trial in early triple‐negative breast cancer but amended to an AED based on emerging data external to the trial suggesting that PD‐L1 status could be a predictive biomarker. Operating characteristics are discussed including the concept of a minimal detectable difference, that is, the smallest observed treatment effect that would lead to a statistically significant result in at least one of the target populations at the interim or the final analysis, respectively, in the setting of AED.
Expanding the Knowledge Base in Literacy Instruction and Assessment: Biliteracy and Translanguaging Perspectives From Families, Communities, and Classrooms
Authors: Noguerón‐Liu Silvia 
Published: September 2020

ABSTRACTThis article is a response to claims made by proponents of “science of reading” and “structured literacy” reading instruction approaches, in regard to their effectiveness with emergent bilingual students. The author argues that the strong knowledge base generated from studies examining the dynamic literacy practices of emergent bilingual students should also be included in reading curriculum, assessment, and teacher education decisions. First, the author provides an overview of the contributions and limitations of the knowledge base associated with the science of reading, in relation to bilingual learners. The author explains that the complexity of the instructional, demographic, and sociocultural realities of emergent bilinguals in the United States requires solutions informed by various vantage points and perspectives. Second, the author summarizes family literacy research in households of Latinx bilingual children, documenting parents’ and children’s advocacy efforts, emergent biliteracy practices, and tensions in grappling with English‐dominant instruction in schools. Finally, the author summarizes research extending oral reading assessment procedures to analyze emergent bilingual students’ miscues and retellings. The author cautions against the implications of critiques of the three‐cueing systems and miscue analysis, by explaining how language‐related perspectives, including translanguaging, can help expand miscue analytic approaches. This expansion can help teachers and families understand how emergent bilinguals draw from their multiple language and literacy resources in decoding and retelling. Implications for teacher preparation and professional development are included throughout.
Graphene Oxide Functionalized Zn(II) Salen Complex: An Efficient and New Route for the Synthesis of 1,2,3‐Triazole Derivatives
Authors: Ghadamyari Zohreh , Khojastehnezhad Amir , Seyedi Seyed Mohammad , Taghavi Faezeh , Shiri Ali 
Published: September 2020

AbstractIn this study, for the first time, the functionalized organometallic graphene oxide (GO) catalyst was prepared by covalently grafting of the Schiff base zinc complex on the surface of GO. The chemical and physical structures of the catalyst were completely characterized by different analyses such as FT‐IR, TEM, EDX, TGA, XRD, SEM and ICP. Then, the applications of nano heterogeneous catalyst have been investigated for the synthesis of 1,2,3‐triazolesviaazide‐alkyne cycloaddition reaction. Although, synthesis of 1,2,3‐triazoles derivatives has been reported by a wide variety of copper catalysts, this is the first report for the synthesis of 1,2,3‐triazoles derivatives catalyzed by heterogeneous Schiff base zinc complex.
Conversion Reaction Mechanism for Yolk‐Shell‐Structured Iron Telluride‐C Nanospheres and Exploration of Their Electrochemical Performance as an Anode Material for Potassium‐Ion Batteries
Authors: Park Gi Dae , Kang Yun Chan 
Published: September 2020

AbstractVarious metal chalcogenide materials have been investigated as novel candidate anode materials for K‐ion batteries (KIBs). This pioneering study explores the electrochemical reaction between K‐ions and iron telluride. A detailed analysis is performed using in situ and ex situ methods, including X‐ray diffraction (XRD), X‐ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), and cyclic voltammetry (CV), following the initial discharging and charging processes. The reversible reaction mechanism, from the second cycle of the reaction of FeTe2 with K‐ions, is 2Fe + K5Te3 + K2Te ↔ 2FeTe1.1 + 1.8Te + 7K+ + 7e‐. Hollow carbon nanospheres housing iron telluride nanocrystals (FeTe2‐C) are synthesized via facile infiltration and a one‐step tellurization process to compensate for the substantial volume change of nanocrystals during the potassiation and depotassiation processes. Excellent electrochemical properties arise from the synergistic effect of the heterointerfaced FeTe1.1 and metalloid Te formed after one cycle and the yolk‐shell architecture with uniformly distributed nanocrystals are embedded in a carbon shell. FeTe2‐C electrode demonstrates remarkable long‐term cycle performance (171 mA h g‐1 for the 500th cycle at a high current density of 0.5 A g‐1) and an excellent rate capability (126 mA h g‐1), even at a high current density of 10 A g‐1.
Cotton textile waste valorization for removal of tetracycline and paracetamol alone and in mixtures from aqueous solutions: Effects of H3PO4 as an oxidizing agent
Authors: Akkouche Fadila , Boudrahem Farouk , Yahiaoui Idris , Vial Christophe , Audonnet Fabrice , Aissani‐Benissad Farida 
Published: September 2020

AbstractThe use of waste and by‐products locally available in large quantities and at low cost as adsorbents can be considered an appropriate approach for improving waste management and protecting the environment. Cotton textile waste was used to prepare adsorbents (MC) via pyrolysis followed by a chemical modification with H3PO4. MC samples were characterized by scanning electron microscopy, FTIR spectroscopy, and N2 adsorption–desorption isotherm. The results revealed that MC treated with 1 M H3PO4 (MC1) showed an excellent adsorption performance. The single and binary adsorption of tetracycline (TC) and paracetamol (Pa) onto MC1 were studied. In a single system, TC was better adsorbed than Pa and maximum adsorption capacities qm are 87.7 mg/g and 62 mg/g, respectively. The adsorption follows the Langmuir and pseudo‐second‐order kinetic models. For a binary system, the experimental data indicate that Pa (44.04 mg/g) is better adsorbed than TC (24.13 mg/g). Adsorption equilibrium data of TC and Pa evaluated by the selectivity extended‐Langmuir model in which selectivity factor was introduced provided good correlation results with the binary adsorption data. Cotton textile waste is potentially promising for the preparation of effective adsorbents for the removal of pharmaceutical residues in aqueous solutions.Practitioner points

Valorization of cotton textile waste into adsorbents.

Adsorbents were prepared by pyrolysis at 600°C followed by chemical modification in the presence of H3PO4.

Removal of tetracycline (TC) and paracetamol (Pa) alone or in mixtures by adsorption.

Adsorbent showed high‐capacity adsorption of the TC and Pa even in a mixture from solutions at low concentrations.

The Langmuir and selectivity extended‐Langmuir models describe the adsorption of TC and Pa alone and in mixtures, respectively.
The Future of Particle Physics: The LHC and Beyond
Authors: Peach Ken 
Published: September 2020

AbstractI have been asked to submit a revised version of this chapter, published almost a decade ago. However, I think that it is better to leave the historical record as it was—this was an article written in its time and for its time. If I was writing this article today, I would call it “The Future of Particle Physics—Beyond the LHC”, in recognition of the fact that, when originally written, the LHC was still under construction and now it has been operating for several years. The other key event which informed the original article was the recently-developed European Strategy for Particle Physics, adopted by the CERN Council in July 2006; the strategy was updated in 2013 and formally adopted in May of that year [1]; as I write, the process of updating the strategy is under way.
The Discovery of the Higgs Boson at the LHC
Authors: Jenni Peter , Virdee Tejinder S. 
Published: September 2020

AbstractIn July 2012 the ATLAS and CMS experiments announced the discovery of a Higgs boson, confirming the conjecture put forward in the 1960’s. This article briefly traces the history of the Brout-Englert-Higgs mechanism, its impact on the elucidation of the standard model, the design and construction of the ATLAS and CMS experiments, and finally the discovery of the Higgs boson. The article outlines some of the challenges faced during the construction of the Large Hadron Collider and its experiments, and their operation and performance. In particular, recent results relating to the properties and couplings of the Higgs boson will be discussed as well future prospects at the LHC.
Pflegebedürftigkeit in Deutschland
Authors: Matzk Sören , Tsiasioti Chrysanthi , Behrendt Susann , Jürchott Kathrin , Schwinger Antje 
Published: September 2020

Zusammenfassung

Zusammenfassung
Der Beitrag liefert ein ausführliches Bild zum Stand der Pflegebedürftigkeit und der gesundheitlichen Versorgung der Pflegebedürftigen in Deutschland. Die Analysen basieren auf GKV-standardisierten AOK-Daten. Sie zeigen Prävalenz, Verläufe und Versorgungsformen der Pflege sowie Kennzahlen zur gesundheitlichen Versorgung der Pflegebedürftigen. Im Fokus stehen die Inanspruchnahme von ärztlichen und stationären Leistungen, Polymedikation und Verordnungen von PRISCUS-Wirkstoffen und Psychopharmaka. Die Ergebnisse werden der Versorgung der Nicht-Pflegebedürftigen gleichen Alters gegenübergestellt und differenziert nach Schwere der Pflegebedürftigkeit und Versorgungssetting ausgewiesen.
The article provides empirical insights on the scope and state of long-term care services in Germany. This includes health service provision for persons in need of care. The article lays out key figures regarding the prevalence, pathways and forms of care based on standardised AOK statutory health insurance data. An additional focus lies on the use of out- and inpatient health care services as well as on polypharmacy and prescriptions of PRISCUS medication and psychotropic drugs. Findings are contrasted with data on members of the same age group who are not in need of care and discussed in relation to the severity of the need of care and the care provision setting.
Zur Organisations- und Finanzierungszuständigkeit von häuslicher Krankenpflege (SGB V) und medizinischer Behandlungspflege (SGB XI)
Authors: Schwinger Antje , Tsiasioti Chrysanthi 
Published: September 2020

Zusammenfassung
Während ein ambulant Pflegebedürftiger heute Behandlungspflege als Sachleistung der Krankenversicherung erhält, zahlen vollstationär Versorgte, für welche die Pflegeversicherung Finanzierungsträger ist, die gleichen Leistungen anteilig selbst. Diese seit nunmehr 25 Jahren fortwährende Ungleichbehandlung bedarf einer Lösung. Hinzu kommt ein Auseinanderdriften der Rahmenbedingungen auch innerhalb der durch die Pflegeversicherung finanzierten ambulanten und vollstationären Pflege, welches eine generelle Neuordnung des Leistungsgeschehens unabhängig vom Ort der Leistungserbringung erforderlich macht. Oberstes Ziel aller Reformanstrengungen muss es sein, die medizinische Behandlungspflege sektorübergreifend einheitlich bei der GKV oder der SPV anzusiedeln. Eine automatische Gleichsetzung der medizinischen Behandlungspflege als GKV-Leistung ist aber zu hinterfragen, da diese auch in der SPV als „Vollleistung“ implementiert werden kann. Wünschenswert wäre, dass Fragen nach den Steuerungsmöglichkeiten und der besseren Wirtschaftlichkeit der Leistungserbringung in der Reformdiskussion einen höheren Stellenwert erhalten, als dies heute der Fall ist. Mit Blick auf das Finanzvolumen, welches bei einer Aufhebung der gesplitteten Finanzierungsverantwortung jeweils verlagert würde, ist ferner eine verbesserte Empirie angeraten.
Von der Schwarzarbeit zum „grauen Markt“ – und darüber hinaus? Neuere und künftig notwendige Entwicklungen der sog. 24-Stunden-Pflege
Authors: Emunds Bernhard , Habel Simone 
Published: September 2020

ZusammenfassungIn der häuslichen Pflege durch migrantische Live-in-Pflegekräfte hat sich in den beiden letzten Jahrzehnten neben einem Schwarzmarkt auch ein „grauer Markt“ mit verschiedenen Formen der partiellen rechtlichen Formalisierung etabliert. Hierbei erweisen sich in allen derzeit bestehenden Modellen die extrem ausgedehnten Arbeitszeiten in rechtlicher und ethischer Hinsicht als größte Herausforderung. Daher bedarf es einer Weiterentwicklung hin zu einer arbeits- und sozialrechtlichen Gleichstellung dieser Erwerbstätigkeit. Einer solchen Entwicklung stehen jedoch gesellschaftliche Faktoren – wie die Naturalisierung weiblicher Sorgearbeit – entgegen.
A conformal dispersion relation: correlations from absorption
Authors: Carmi Dean , Caron-Huot Simon 
Published: September 2020

AbstractWe introduce the analog of Kramers-Kronig dispersion relations for correlators of four scalar operators in an arbitrary conformal field theory. The correlator is expressed as an integral over its “absorptive part”, defined as a double discontinuity, times a theory-independent kernel which we compute explicitly. The kernel is found by resumming the data obtained by the Lorentzian inversion formula. For scalars of equal scaling dimensions, it is a remarkably simple function (elliptic integral function) of two pairs of cross-ratios. We perform various checks of the dispersion relation (generalized free fields, holographic theories at tree-level, 3D Ising model), and get perfect matching. Finally, we derive an integral relation that relates the “inverted” conformal block with the ordinary conformal block.
A Variant of the Mountain Pass Theorem and Variational Gluing
Authors: Montecchiari Piero , Rabinowitz Paul H. 
Published: September 2020

AbstractThis paper surveys some recent work on a variant of the Mountain
Pass Theorem that is applicable to some classes of differential equations involving
unbounded spatial or temporal domains. In particular its application to a system
of semilinear elliptic PDEs on $$R^n$$

R
n

and to a family of Hamiltonian systems involving
double well potentials will also be discussed.
$$L^p$$-theory for a fluid–structure interaction model
Authors: Denk Robert , Saal Jürgen 
Published: September 2020

AbstractWe consider a fluid–structure interaction model for an incompressible fluid where the elastic response of the free boundary is given by a damped Kirchhoff plate model. Utilizing the Newton polygon approach, we first prove maximal regularity in$$L^p$$Lp-Sobolev spaces for a linearized version. Based on this, we show existence and uniqueness of the strong solution of the nonlinear system for small data.
Automatic monitoring of steel strip positioning error based on semantic segmentation
Authors: Lemos Aline de Faria , da Silva Leonardo Adolpho Rodrigues , Nagy Balázs Vince 
Published: September 2020

AbstractThe misalignment of steel strips in relation to the roller table centerline still is an impairment for the rolling mill production lines. Nowadays, the strip position correction remains largely in the purview of human analysis, in which the strip steering is traditionally a semi-manual operation. Automating the alignment process could reduce the maintenance costs, damage to the plant, and prevent material losses. The first step into the automatization is to determine the strip position and its referred error. This study presents a method that employs semantic segmentation based on convolution neural networks to estimate steel strips positioning error from images of the process. Additionally, the system mitigates the influences of mechanical vibration on the images. The system performance was assessed by standard semantic segmentation evaluation metrics and in comparison with the dataset ground truth. The results showed that 97% of the estimated positioning errors are within a 2-pixel margin. The method demonstrated to be a robust real-time solution as the networks were trained from a set of low-resolution images acquired in a complex environment.