bluuebunny/crossref_metadata_2025_split huggingface dataset:
The outcome for surgical fixation of distal radial fractures in patients with idiopathic Parkinson’s disease: a cohort study
Authors: Chou Te-Feng Arthur , Chang Chun Yao , Huang Chun-Ching , Chang Ming-Chau , Chen Wei-Ming , Huang Tung-Fu 
Published: April 2020

Abstract
Introduction
Idiopathic Parkinson’s disease (PD) is a progressive neurologic disorder causing postural instability and unsteady gait. These patients are at increased risk for fractures and have inferior outcomes after treatment. Several studies have evaluated the incidence and outcome of PD patients after hip fractures. However, there are limited studies assessing the outcome of upper extremity fractures in these patients. In this study, we evaluated the outcome of PD patients that received surgical intervention for distal radial fractures (DRF). We hypothesize that these patients have an inferior outcome after surgery in comparison with non-PD patients.

Methods
Between May 2005 and May 2017, we retrospectively reviewed all of the patients with DRF and subsequently underwent open reduction and internal fixation (ORIF) at a level 1 trauma center. All of the surgeries were performed by fellowship-trained orthopedic surgeons. The inclusion criteria include patients with a definitive diagnosis of PD, non-pathological DRF, and a minimum follow-up of 1 year or up until the time of treatment failure was noted. Each PD patient was matched for age and gender to 3 non-PD patients. The primary objective was to determine the failure rate after surgical fixation for DRF. The secondary outcomes include time to treatment failure, reoperation rate, readmission rate, length of hospital stay, and postoperative complications.

Results
A total of 88 patients were included in this study (23 PD, 65 non-PD patients). All underwent ORIF and received standard postoperative follow-ups. The overall treatment failure rate in PD was 39.1% vs. 4.6% in the non-PD group (p < 0.05). The time to treatment failure were 9.11 ± 3.86 weeks and 14.67 ± 5.8 weeks for PD and non-PD, respectively (p < 0.05). PD patients had a significantly higher rate of failure when k-wires and ESF were used (p < 0.05%), while loss of reduction was the most common mode of failure in PD (44.4%). The length of hospital stay for PD was 5.3 ± 4.69 days compared with 3.78 ± 0.96 days for non-PD (p = 0.01). There were 3 PD patients readmitted within 30 days after surgery, and 1 patient had pneumonia after the surgery.

Conclusion
This study revealed that patients with PD have a high treatment failure rate despite surgical intervention for DRF. PD patients had a longer hospital stay and had a shorter time to treatment failure. In treating PD patients complicated with DRF, the surgeon must take into consideration the complex disease course of PD and the associated comorbidities such as osteoporosis, frail status, and frequent falls. Rehabilitation and disposition plans should be discussed in advance and longer hospital stays should be expected.
Level of evidenceLevel IV, retrospective cohort study
The usefulness of C-reactive protein as a biomarker in predicting neonatal sepsis in a sub-Saharan African region
Authors: Bunduki Gabriel Kambale , Adu-Sarkodie Yaw 
Published: April 2020

AbstractObjectiveThe early diagnosis of neonatal sepsis remains a challenge for physicians. The initiation or/and discontinuation of the empirical antibiotic therapy at neonates with sepsis is a dilemma due to the lack of definitive diagnosis and the fear of misdiagnosing a case with its serious outcomes, which can follow up. Therefore, this study aimed to assess the usefulness of C-reactive protein (CRP) as an inflammatory biomarker in the prediction of the neonatal sepsis diagnosis in Butembo, the Democratic Republic of the Congo, in sub-Saharan Africa. Blood culture and quantitative CRP measurements were performed for each neonate. Receiver operating characteristics (ROC) analyses were done in the assessment of CRP accuracy in diagnosing neonatal sepsis.ResultsOf the 228 neonates screened for sepsis, 69 (30.3%) had a positive blood culture. Of the 228 neonates with suspected sepsis, 94 (41.2%) had a positive CRP. Among the 69 cases with positive blood culture, CRP identified 66 cases. The sensitivity, specificity, positive and negative predictive values of CRP were 95.7%, 82.4%, 70.2%, and 97.8%, respectively. The area under the curve (AUC) for the CRP ROC analysis was 0.948. CRP showed its usefulness in the diagnosis of neonatal sepsis.
Automated gene data integration with Databio
Authors: Reid Robert W. , Ferrier Jacob W. , Jay Jeremy J. 
Published: April 2020

Abstract
Objective
Although sequencing and other high-throughput data production technologies are increasingly affordable, data analysis and interpretation remains a significant factor in the cost of -omics studies. Despite the broad acceptance of findable, accessible, interoperable, and reusable (FAIR) data principles which focus on data discoverability and annotation, data integration remains a significant bottleneck in linking prior work in order to better understand novel research. Relevant and timely information discovery is difficult for increasingly multi-disciplinary projects when scientists cannot easily keep up with work across multiple fields. Computational tools are necessary to accurately describe data contents, and empower linkage to existing resources without prior knowledge of the various database resources.

Results
We developed the Databio tool, accessible at https://datab.io/, to automate data parsing, identifier detection, and streamline common tasks to provide a point-and-click approach to data manipulation and integration in life sciences research and translational medicine. Databio uses fast real-time data structures and a data warehouse of 137 million identifiers, with automated heuristics to describe data provenance without highly specialized knowledge or bioinformatics training.
Activated phosphoinositide 3-kinase delta syndrome 1 and 2 (APDS 1 and APDS 2): similarities and differences based on clinical presentation in two boys
Authors: Ewertowska Marlena , Grześk Elżbieta , Urbańczyk Anna , Dąbrowska Anna , Bąbol-Pokora Katarzyna , Łęcka Monika , Kołtan Sylwia 
Published: April 2020

Abstract
Background
Activated PI3K delta syndrome (APDS) belongs to the heterogeneous group of primary immunodeficiency disorders (PIDs). Progress in next-generation sequencing (NGS) enabled identification of gain-of-function mutations in phosphoinositide 3-kinase (PI3K) genes. Depending on the type of causative mutation, APDS is classified into two types: APDS 1 and APDS 2. To date, less than 100 cases of APDS have been reported. Clinical symptoms of APDS result from impaired immune regulation and are clinically manifested by recurrent infections, allergies, lymphoproliferation and autoimmunity. They show similarity to other PIDs. Therefore, many patients were diagnosed incorrectly. The availability of genetic testing has allowed establishing the correct diagnosis in increasing number of patients suffering from APDS.

Case presentations
The first male patient presented in infancy with recurrent infections. Subsequently he was found to suffer from hepatosplenomegaly, early portal hypertension, massive lymphoproliferation and hypogammaglobulinemia. The common E1021K mutation in the PI3KCD gene was identified. The patient underwent successful hematopoietic stem cell transplantation with resolution of most symptoms. The second patient suffered from persistent growth retardation since early life, facial dysmorphism and recurrent respiratory infections from early childhood. He was found to have systemic lympho-proliferation, panhypoglobulinemia and impaired antibody responses to vaccines. The introduction of NGS in Poland enabled rapid identification of a mutation in the PI3KR1 gene. Growth hormone administration seemed to have worsened the lymphoproliferation.

Conclusions
Patients with suspected common variable immunodeficiency (CVID) and additional symptoms, such as allergy, facial dysmorphia, short stature, enhanced lymphoproliferation and lack of adequate response to human immunoglobulin replacement therapy, should be considered for NGS-based genetic testing. It may substantially shorten the time needed to establish the correct diagnosis, direct appropriate treatment and avoid potentially harmful therapies. To date, few cases of APDS have been described. It is important to report each of them to establish clinical indices and laboratory biomarkers of APDS 1 and APDS 2, to develop the standards of care in these conditions.
The existence of solutions for nonlinear fractional boundary value problem and its Lyapunov-type inequality involving conformable variable-order derivative
Authors: Wang Jie , Zhang Shuqin 
Published: April 2020

AbstractWe consider a nonlinear fractional boundary value problem involving conformable variable-order derivative with Dirichlet conditions. We prove the existence of solutions to the considered problem by using the upper and lower solutions’ method with Schauder’s fixed-point theorem. In addition, under some assumptions on the nonlinear term, a new Lyapunov-type inequality is given for the corresponding boundary value problem. The obtained inequality provides a necessary condition for the existence of nontrivial solutions to the considered problem and a method to prove uniqueness for the nonhomogeneous boundary value problem. These new results are illustrated through examples.
Letter to the editor regarding the article ‘EFSA’s toxicological assessment of aspartame: was it even-handedly trying to identify possible unreliable positives and unreliable negatives?’
Authors: Kass George E. N. , Lodi Federica 
Published: April 2020

AbstractThis letter is in response to a recent paper by Millstone and Dawson (2019) in which the authors criticise the re-evaluation of the high intensity sweetener aspartame in 2013 by the former EFSA’s Panel on Food Additives and Nutrient Sources added to Food, on the grounds that EFSA did not follow its own procedures for its risk assessment. Moreover, the authors claim that the appraisal of the available studies was asymmetrically more alert to putative false positives than to possible false negatives. In this letter it is shown that the methodology for collection and selection of the scientific information used as a basis for the aspartame risk assessment, and the inclusion/exclusion criteria applied were defined a priori and documented in the published opinion. Furthermore, the Panel applied a Weight-of-Evidence approach combined with an analysis of the biological relevance of the appraised and validated evidence for its analysis, integration and interpretation, followed by an uncertainty analysis. Finally, an analysis of the distribution of negative versus positive outcome of the studies in the context of reliability showed that the claim of bias in the scientific risk assessment of aspartame is not substantiated.
Renal artery stenosis presenting as preeclampsia
Authors: Omar Michael Brandon , Kogler William , Maharaj Satish , Aung Win 
Published: April 2020

Abstract
Background
Renal artery stenosis is a notorious cause of secondary hypertension which classically presents as chronic refractory hypertension, recurrent flash pulmonary edema or renal insufficiency after initiation of an angiotensin converting enzyme inhibitor. Rarely, there have been reported cases of pregnant patients presenting with new onset or superimposed preeclampsia secondary to renovascular hypertension. In this subset of patients, renovascular hypertension carries significantly higher risks including obstetric, fetal and medical emergencies and death. Prompt treatment is required. However, the teratogenic risks of radiological investigations and antihypertensive medications limit diagnostic and management options thus posing quite a dilemma.

Case presentation
A 38-year-old female, at 33 weeks of gestation, was hospitalized for preeclampsia with severe features. A viable neonate had been expeditiously delivered yet the patient’s post-partum blood pressures remained severely elevated despite multi-class anti-hypertensive therapy. Renal artery dopplers revealed greater than 60% stenosis of the proximal left renal artery and at least 60% stenosis of the right renal artery. Renal angiography showed 50% stenosis of the left proximal renal artery for which balloon angioplasty and stenting was performed. The right renal artery demonstrated less than 50% stenosis with an insignificant hemodynamic gradient, thus was not stented. Following revascularization, the patient’s blood pressure improved within 48 h, on dual oral antihypertensive therapy.

Conclusions
Preeclampsia that is refractory to multi-drug antihypertensive therapy should raise suspicion for renal artery stenosis. Suspected patients can be screened safely with Doppler ultrasonography which can be then followed by angiography. Even if renal artery stenosis does not seem severe, early renal revascularization may be considered in patients with severe preeclampsia who do not respond to antihypertensive management.
Workplace-related stress among oncologists: Egyptian single-centered observational study
Authors: Soltan M. R. , Al-Hassanin S. A. , Soliman S. S. , Gohar S. F. 
Published: April 2020

Abstract
Background
The oncologists are facing more challenges than ever before in their work with cancer patients. The aim of the study is to assess the level of work-related stress among oncology clinicians and to compare it with non-oncologists. Thirty oncologists working at clinical oncology department at Menoufia University hospitals, Egypt, were compared to an equal number of non-oncologists matched for the same gender and work duration. After consent, all the participants were interviewed using a structured questionnaire to collect background information and the workplace stress scale (WSS) was used to ascertain their stress level.

Results
The percentage distribution of different grades of WSS among the two groups did not show any significant difference (P = 0.84). Gender had no significant association to the mean score of WSS (P > 0.05). All the juniors (residents) in this study with work duration ≤ 3 years had significantly higher levels of WSS than seniors (> 3 years), P < 0.001. Among oncologists or non-oncologists, juniors showed significantly higher levels of WSS than seniors (P = 0.003 and < 0.001 respectively). However, junior oncologists had no significant difference than junior non-oncologists and seniors in both groups did not show any significant difference regarding the mean score of WSS.

Conclusion
All the workers within the two groups had experienced work-related stress. However, there was no statistically significant difference among them regarding the different grades of work place stress scale.
A compact conductor-backed CPW-based dual bandpass filter for satellite S-band and C-band
Authors: Oudaya Coumar S. , Tamilselvan S. 
Published: April 2020

AbstractAn efficient and compact dual bandpass filter having single narrow rejection band between S-band and C-band using CPW arrangement is proposed. The half wavelength square resonator is used in ground surface to eliminate certain frequency bands. The transmission zero of rejection band is restricted by modifying the dimension of the resonator. The CPW-based DB-BPF is simulated and tested with its equivalent prototype. This work emphasizes DB-BPF with square resonator coupling constructed on CPW process. An innovative integration of circular resonator incorporated with inter-digital line coupling in the top surface of the substrate and square resonator at the bottom surface of the substrate produces wide band and narrow stop band, respectively. The DB-BPF has remarkable bandwidth from 2 to 3.8 GHz and 4.3 to 7.8 GHz as S-band and C-band, respectively. Hence, the overall bandwidth of the filter is 5.3 GHz (1.8 GHz and 3.5 GHz). The filter performances are evaluated and analyzed through the factors like S-parameters, Q-factor and group delay. The overall dimension of DB-BPF is achieved to be (39 × 4.5 × 1.6) mm3, which is very much compact in dimension. The filter characteristics show the return loss of − 35.2 dB and insertion loss of − 1.2 dB which are validated by measured results.
The control of metabolic traits by octopamine and tyramine in invertebrates
Authors: Roeder Thomas 
Published: April 2020

ABSTRACT
Octopamine (OA) and tyramine (TA) are closely related biogenic monoamines that act as signalling compounds in invertebrates, where they fulfil the roles played by adrenaline and noradrenaline in vertebrates. Just like adrenaline and noradrenaline, OA and TA are extremely pleiotropic substances that regulate a wide variety of processes, including metabolic pathways. However, the role of OA and TA in metabolism has been largely neglected. The principal aim of this Review is to discuss the roles of OA and TA in the control of metabolic processes in invertebrate species. OA and TA regulate essential aspects of invertebrate energy homeostasis by having substantial effects on both energy uptake and energy expenditure. These two monoamines regulate several different factors, such as metabolic rate, physical activity, feeding rate or food choice that have a considerable influence on effective energy intake and all the principal contributors to energy consumption. Thereby, OA and TA regulate both metabolic rate and physical activity. These effects should not be seen as isolated actions of these neuroactive compounds but as part of a comprehensive regulatory system that allows the organism to switch from one physiological state to another.
Selective non-operative management for penetrating abdominal injury in a Dutch trauma centre
Authors: Waes OJF Van , Lieshout EMM Van , Silfhout DJ Van , Halm JA , Wijffels MME , Vledder MG Van , Graaff HP De , Verhofstad MHJ 
Published: April 2020

Introduction Selective non-operative management (SNOM) for penetrating abdominal injury (PAI) is accepted in trauma centres in South Africa and the US. Owing to the low incidence of gunshot wounds (GSWs) in Western Europe, few are inclined to practise SNOM for such injuries although it is considered for stab wounds (SWs). This study evaluated the outcome of patients admitted to a Dutch level 1 trauma centre with PAI. Methods A retrospective study was undertaken of all PAI patients treated over 15 years. In order to prevent bias, patients admitted six months prior to and six months following implementation of a treatment algorithm were excluded. Data concerning type of injury, injury severity score and treatment were compared. Results A total of 393 patients were included in the study: 278 (71%) with SWs and 115 (29%) with GSWs. Of the 178 SW patients in the SNOM group, 111 were treated before and 59 after introduction of the protocol. The SNOM success rates were 90% and 88% respectively (p=0.794). There were 43 patients with GSWs in the SNOM cohort. Of these, 32 were treated before and 11 after implementation of the algorithm, with respective success rates of 94% and 100% (p=0.304). The protocol did not bring about any significant change in the rate of non-therapeutic laparotomies for SWs or GSWs. However, the rate of admission for observation for SWs increased from 83% to 100% (p<0.001). There was a decrease in ultrasonography for SWs (from 84% to 32%, p<0.001) as well as for GSWs (from 87% to 43%, p<0.001). X-ray was also used less for GSWs after the protocol was introduced (44% vs 11%, p=0.001). Conclusions SNOM for PAI resulting from either SWs or GSWs can be safely practised in Western European trauma centres. Results are comparable with those in trauma centres that treat high volumes of PAI cases.
YVO4 cascaded Raman laser for five-visible-wavelength switchable emission
Authors: Duan Yanmin , Sun Yinglu , Zhu Haiyong , Mao Tingwei , Zhang Li , Chen Xiang 
Published: April 2020

We report switchable emission of visible light at five wavelengths generated in a

YVO
4

cascaded Raman cavity driven by an acousto-optic

Q

-switched Nd:YAP laser at 1080 nm. The second-harmonic generation and sum-frequency generation of the fundamental, first-Stokes, and second-Stokes waves were realized based on the angle-tuned BBO crystal. The phase-match angle tuning span of a BBO crystal is only approximately 2.3° to allow the frequency mixing to produce five visible wavelengths on demand. At an absorbed pump power of 5.96 W and a pulse repetition frequency of 10 kHz, average output powers of 800, 340, 460, 190, and 326 mW were obtained for 539.9, 567.2, 597.4, 631.0, and 668.5 nm lasers, respectively. The results show that the cascaded Raman laser system with an angle-tuned BBO crystal can provide a convenient and efficient method to achieve wavelength-switchable visible emission for multi-wavelength laser applications.
Polityczne uwarunkowania wschodnioazjatyckiego modelu rozwoju: ustrój, instytucje i warunki zewnętrzne
Authors: Bolesta Andrzej 
Published: April 2020

Artykuł analizuje polityczne uwarunkowania wschodnioazjatyckiego modelu rozwoju, skupiając się na ustroju politycznym, instytucjach oraz warunkach zewnętrznych. Model ów odpowiada za spektakularne osiągnięcia rozwojowe niektórych państw Azji Wschodniej i opiera się na koncepcji państwa rozwojowego, którego głównym celem jest nadrabianie zaległości rozwojowych wobec państw wysoko rozwiniętych. Analiza ma za zadanie odpowiedzenie na pytanie dotyczące preferowanego typu ustroju politycznego dla realizacji celów państwa rozwojowego, określenie kluczowych dla jego funkcjonowania instytucji oraz opisanie specyficznych zewnętrznych warunków politycznych.
W toku analizy stwierdzono, iż koncepcję można wprowadzić zarówno w państwach o ustroju demokratycznym, jak i autorytarnym. Państwo autorytarne może posiadać lepsze środowisko polityczne dla celów państwa rozwojowego, niemniej jednak sam system polityczny ma znaczenie drugorzędne. Kluczowe są natomiast odpowiednie i dobrze funkcjonujące instytucje, takie jak prawa własności i umiejętność korygowania nieprawidłowości w funkcjonowaniu rynku. Państwo rozwojowe jest państwem silnym, zdolnym do zmobilizowania społeczeństwa i sektora biznesowego na rzecz celów rozwojowych. Jego pozycja jest częściowo wynikiem uwarunkowań zewnętrznych. Historyczne państwa rozwojowe powstały w okresie zimnej wojny, a sytuacja międzynarodowa ułatwiała mobilizację społeczeństwa i zapewniała wsparcie polityczne i gospodarcze Stanów Zjednoczonych.
Instytucja referendum ogólnokrajowego na Ukrainie – aspekt normatywny
Authors: Pietnoczka Paweł 
Published: April 2020

Celem artykułu jest przybliżenie rozwiązań prawnych regulujących instytucję referendum ogólnokrajowego na Ukrainie w okresie niepodległości. Z zamiarem jego osiągnięcia wykorzystana została metoda instytucjonalno-prawna. Analizie poddano przepisy poszczególnych aktów prawnych, w tym „Konstytucji Ukraińskiej Socjalistycznej Republiki Radzieckiej” z 1978 r., „Umowy konstytucyjnej pomiędzy Radą Najwyższą Ukrainy a Prezydentem Ukrainy” z 1995 r., „Konstytucji Ukrainy” z 1996 r., „Ustawy o ogólnoukraińskim i lokalnym referendum” z 1991 r., „Ustawy Ukrainy o Centralnej Komisji Wyborczej” z 2004 r. oraz „Ustawy Ukrainy o referendum ogólnoukraińskim” z 2012 roku. Uwaga została skupiona na regulacjach prawnych określających m.in. przedmiot referendum ogólnokrajowego, podmioty uprawnione do jego inicjowania i zarządzania, tryb powoływania komisji referendalnych, sposób ustalania wyników oraz skutki prawne referendum.
Ustawa o referendum ogólnoukraińskim z 2012 r., której przepisy były niejednokrotnie krytykowane przez środowiska eksperckie oraz część polityków, w kwietniu 2018 r., została uznana przez Sąd Konstytucyjny Ukrainy za niezgodną z konstytucją. W związku z tym obecnie brak jest na Ukrainie przepisów ustawowych regulujących zasady i tryb przeprowadzania referendum ogólnokrajowego. Ten stan rzeczy zmieniłoby przyjęcie któregoś z zarejestrowanych w parlamencie projektów. Jednak dotychczasowa praca deputowanych wskazuje, że Radzie Najwyższej VIII kadencji brakuje woli politycznej, aby przyjąć ustawę umożliwiającą obywatelom bezpośrednie decydowanie o ważnych sprawach życia państwowego.