bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased dose primary thromboprophylaxis in ambulatory patients with advanced pancreatic ductal adenocarcinoma, a single centre cohort study
Authors: Maraveyas Anthony , Haque Farzana , Muazzam Iqtedar Ahmed , Ilyas Waqas , Bozas George 
Published: May 2020

Abstract
Background
Advanced pancreatic ductal adenocarcinoma (aPDAC) patients have a lifetime all type thromboembolic event (ATTE) rate of 25–35%. Efficacy and safety of increased dose primary thromboprophylaxis (IDPTP) with low molecular heparin (LMWH) given for 3 months has been shown in two prospective randomized trials.

Objectives
To report on efficacy -reduction of all type thromboembolic events (ATTE)-, safety -incidence of Major Bleeding (MB)- and compliance in a single-centre cohort of aPDAC patients receiving first line chemotherapy and LMWH-IDPTP.

Methods
From May 2009 to October 2016, 82 patients received IDPTP –LMWH with dalteparin. Schedule: 55 kg and below: 7500 IU, between 55 and 80 kg: 10,000 IU, above 80 kg: 12,500 IU. MB is reported using the International Society of Thrombosis and Haemostasis (ISTH) criteria. ATTE was defined as any arterial or venous event, incidental or clinically symptomatic, including visceral VTE.

Results
Mean and median time on dalteparin was 10.2 (95%CI 8.1, 12.4) and 8.0 (95%CI 6.2, 9.7) months respectively. ATTE was observed in 7 (8.5%) of patients, with a median time on IDPTP of 6.2 months (95% CI 10.0, 13.2). MB was seen in 10 (12.2%) patients with a median time on IDPTP of 4.5 months (95% CI 1.6, 7.4). Six major bleeds (60%) were the direct or indirect result of aPDAC. Eighty-one patients had died at the time of data collection with a median overall survival time of 8.7 months (95%CI 6.4, 11.0). Thromboembolism and bleeding were late events. No impact of thromboembolism or bleeding on overall survival was observed.

Conclusions
IDPTP-dalteparin was associated with lower ATTE occurrence rates than expected and comparable major bleeding rates. ATTE and MB were late events, the majority of MB was from direct or indirect result of locally progressing aPDAC. Since these conditions can frequently arise in aPDAC, IDPTP should be regularly reviewed beyond 3 months.
Comorbidity of disruptive behavior disorders and intermittent explosive disorder
Authors: Radwan Karam , Coccaro Emil F. 
Published: May 2020

Abstract
Background
Aggressive behavior in children and adolescents may be accounted for by several disruptive behavioral disorders (DBD) including attention-deficit/hyperactive (ADHD), conduct (CD), and oppositional defiant (ODD), disorders and intermittent explosive disorder (IED). The comorbidity among the DBDs is well known, but not its comorbidity with IED.

Method
We reanalyzed data from the National Comorbidity Studies (adolescents and adults), and from a large clinical research adult sample, to estimate the comorbidity of IED with each of the DBDs and to explore correlates of these comorbidities.

Results
The rate of current comorbidity between IED and the DBDs ranged from 10 to 19%, in adolescents (5–14% in adults) with odds ratios of about five. The onset of ADHD typically appeared before onset of IED while onset ODD and CD more typically appeared before that of IED in adolescents and about equally before or after IED in adults but IED persisted outside the duration window in many (ADHD) or most (ODD, CD) cases. Measures of impulsive aggression severity were highest in those with IED+DBD but relatively low in those with DBD alone while measures of DBD severity were highest in those with DBD alone and in those with IED+DBD.

Conclusion
Despite the comorbidity of IED with the DBDs, IED can be separated from the DBDs over time and in terms of severity measures of IED and of DBD. Overall, impulsive aggression varies with IED while DBD behaviors vary with DBD. Based on this, clinicians should consider IED in their differential in the workup of impulsively aggressive children and adolescents.
Foot health of Aboriginal and Torres Strait Islander Peoples in regional and rural NSW, Australia
Authors: West Matthew , Sadler Sean , Hawke Fiona , Munteanu Shannon E. , Chuter Vivienne 
Published: May 2020

AbstractBackgroundFoot health of Aboriginal and Torres Strait Islander Australians' has not been established. Additionally, studies have shown that there is a lack of engagement of this population with general preventive foot care services. The aim of this study was to establish foot health in Aboriginal and Torres Strait Islander people attending two recently developed, culturally safe podiatry services in rural and regional New South Wales (NSW), Australia. Secondarily the relationship between self‐perceived foot health and some medical and demographic characteristics was investigated.MethodsThis descriptive cross‐sectional study included participants attending the culturally safe foot health care services managed by the University of Newcastle on the Central Coast or in Wellington, both located in NSW, Australia. At the consultation, participants completed the Foot Health Status Questionnaire (FHSQ) with the assistance of an Aboriginal health care worker, underwent basic vascular and neurological screening, and podiatric treatment.ResultsA total of 111 Aboriginal and Torres Strait Islander Australians (48 from the Central Coast, and 63 from Wellington) were included. FHSQ scores for pain (75.7 ± 26.8), function (80.2 ± 25.2), footwear (53.9 ± 33.4), and general foot health (62.0 ± 30.9) were generally good, but below the optimal score of 100. The presence of diabetes (n = 39 of 111 participants or 35.1%) was associated with lower levels of self‐perceived foot function (r = − 0.20, n = 107, p = 0.04).ConclusionWe found that community‐based foot health care services that are culturally safe are utilised by Aboriginal and Torres Strait Islander Peoples not currently at high risk of foot complications. This supports the use of culturally safe foot care services to improve engagement with preventative foot care. Future research should continue to be driven by Aboriginal and Torres Strait Islander Peoples and investigate ways to implement additional screening measures and undertake prospective evaluation of the impact of such services on health related outcomes in these communities.
Functional production of human antibody by the filamentous fungus Aspergillus oryzae
Authors: Huynh Hung Hiep , Morita Naoki , Sakamoto Toshihiro , Katayama Takuya , Miyakawa Takuya , Tanokura Masaru , Chiba Yasunori , Shinkura Reiko , Maruyama Jun-ichi 
Published: May 2020

AbstractBackgroundMonoclonal antibodies (mAbs) as biopharmaceuticals take a pivotal role in the current therapeutic applications. Generally mammalian cell lines, such as those derived from Chinese hamster ovaries (CHO), are used to produce the recombinant antibody. However, there are still concerns about the high cost and the risk of pathogenic contamination when using mammalian cells.Aspergillus oryzae, a filamentous fungus recognized as a GRAS (Generally Regarded As Safe) organism, has an ability to secrete a large amount of proteins into the culture supernatant, and thus the fungus has been used as one of the cost-effective microbial hosts for heterologous protein production. Pursuing this strategy the human anti-TNFα antibody adalimumab, one of the world’s best-selling antibodies for the treatment of immune-mediated inflammatory diseases including rheumatoid arthritis, was chosen to produce the full length of mAbs byA. oryzae. Generally,N-glycosylation of the antibody affects immune effector functions such as antibody-dependent cell-mediated cytotoxicity (ADCC) via binding to the Fc receptor (FcγR) on immune cells. The CRISPR/Cas9 system was used to first delete theAooch1gene encoding a key enzyme for the hyper-mannosylation process in fungi to investigate the binding ability of antibody with FcγRIIIa.ResultsAdalimumab was expressed inA. oryzaeby the fusion protein system with α-amylase AmyB. The full-length adalimumab consisting of two heavy and two light chains was successfully produced in the culture supernatants. Among the producing strains, the highest amount of antibody was obtained from the ten-protease deletion strain (39.7 mg/L). Two-step purifications by Protein A and size-exclusion chromatography were applied to obtain the high purity sample for further analysis. The antigen-binding and TNFα neutralizing activities of the adalimumab produced byA. oryzaewere comparable with those of a commercial product Humira®. No apparent binding with the FcγRIIIa was detected with the recombinant adalimumab even by altering theN-glycan structure using theAooch1deletion strain, which suggests only a little additional activity of immune effector functions.ConclusionThese results demonstrated an alternative low-cost platform for human antibody production by usingA. oryzae, possibly offering a reasonable expenditure for patient’s welfare.
The impact of summer programming on the obesogenic behaviors of children: behavioral outcomes from a quasi-experimental pilot trial
Authors: Dugger R. , Brazendale K. , Hunt E. T. , Moore J. B. , Turner-McGrievy G. , Vogler K. , Beets M. W. , Armstrong B. , Weaver R. G. 
Published: May 2020

Abstract
Background
Children from low-income families experience accelerated BMI gain and learning loss during summer. Healthy Summer Learners (HSL) addresses accelerated BMI gain and academic learning loss during summer by providing academic- and health-focused programming. This manuscript reports the effects of HSL on underlying obesogenic behaviors (i.e., physical activity, screen time, sleep, diet) that lead to accelerated summer BMI gain, a necessary first step to informing a future randomized controlled trial of HSL.

Methods
In the summer of 2018 and 2019 using a quasi-experimental study design, 180 children (90 per summer, 7.9 years [SD = 1.0], 94% non-Hispanic Black, 40% male) at two schools (i.e., one per summer) who were struggling academically (25–75% on a standardized reading test) were provided a free, school-based 6-week health- and academic-focused summer program (i.e., HSL, n = 60), a 4- to 6-week academic-focused summer program (i.e., 21st Century Summer Learning program (21C), n = 60), or no summer program (n = 60). Children wore the Fitbit Charge 2™ over a 10-week period during the summers (June–Aug) of 2018–2019. Differences within (within child days attend vs. not attend) and between (differences between groups attend vs. not attend) were evaluated using mixed effects linear regression.

Results
Regression estimates indicated that, on days attending, HSL children experienced a greater reduction in sedentary minutes (− 58.6 [95% CI = − 92.7, − 24.4]) and a greater increase in moderate-to-vigorous physical activity (MVPA) (36.2 [95% CI = 25.1, 47.3]) and steps (2799.2 [95% CI = 2114.2, 3484.2]) compared to 21C children. However, both HSL and 21C children were more active (i.e., greater MVPA, total steps) and less sedentary (i.e., less sedentary minutes and total screen time) and displayed better sleeping patterns (i.e., earlier and less variability in sleep onset and offset) on days they attended than children in the control.

Conclusions
HSL produced greater changes in physical activity than 21C. However, attendance at either HSL or 21C leads to more healthy obesogenic behaviors. Based on the behavioral data in this pilot study, a larger trial may be warranted. These results must be considered along with the pending primary outcomes (i.e., academics and BMI z-score) of the HSL pilot to determine if a full-scale trial is warranted.

Trial registration
NIH-NCT03321071. Registered 25 October 2017
Proposal and Verification of a Novel Superhydrophobic-Conductive Anti-Corrosion Polyaniline-Silica Coating
Authors: Xu Haidong , Fan Suohong , Lu Yong , Feng Huixia , Qiu Jianhui 
Published: May 2020

Abstract
There has been a growing interest in stainless steel (SS) corrosion due to massive economic losses. Current efforts are mainly devoted to forming Cr2O3 film or organic coatings on SS surfaces. However, the relevant chromate is a carcinogen and the traditional organic coatings are inefficient for electrochemical corrosion. Here, we prepared a novel superhydrophobic-conductive anti-corrosion polyaniline-silica (PANI-SiO2) coating, the internal conductive polyaniline layer effectively reduces electrochemical corrosion, the external superhydrophobic silica layer obviously reduces chemical corrosion. Compared with 304 stainless steel (304SS), the corrosion potential (Ecorr) of the PANI-SiO2 increases to more than 331 mV (SCE), the corrosion current (Icorr) is reduced by more than one order of magnitude, and the anti-corrosion efficiency reaches 97.51%. Meanwhile, the PANI-SiO2 coating has good long-term anti-corrosion performance for 304SS.
Sodium-Metal-Promoted Reductive 1,2-syn-Diboration of Alkynes with Reduction-Resistant Trimethoxyborane
Authors: Ito Shiori , Fukazawa Mizuki , Takahashi Fumiya , Nogi Keisuke , Yorimitsu Hideki 
Published: May 2020

Abstract
Reductive 1,2-diboration of alkynes has been accomplished by means of sodium dispersion in the presence of trimethoxyborane as a reduction-resistant boron electrophile. Two boron moieties can be introduced onto alkynes with excellent syn selectivity to afford the corresponding (Z)-1,2-diborylalkenes. Bis(borate) species generated in situ can be involved in one-pot Suzuki-Miyaura arylation, formal arylboration of alkynes thus being executed.
Safety and efficacy of endovascular implantation of a portal vein stent combined with iodine-125 seed-strips followed by transcatheter arterial chemoembolization with sorafenib for the treatment of hepatocellular carcinoma with portal vein tumor thrombosis
Authors: Li Shuangxi , Li Lei , Li Baohua , Wang Wenhui 
Published: May 2020

Objective:
To assess the safety and efficacy of endovascular implantation of a portal vein stent combined with iodine-125 seed-strips followed by transcatheter arterial chemoembolization with sorafenib (PVS-125I-TACE-S) for the treatment of hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT).

Methods:
Between January 2015 and July 2017, 18 patients with PVTT caused by HCC that were treated with PVS-125I-TACE-S were reviewed. The technical success, complications, changes in liver function from baseline values due to subsequent endovascular implantation of a portal vein stent combined with iodine-125 seed-strips (PVS-125I), time-to-tumor progression (TTP) and overall survival (OS) were observed.

Results:
The technical success rate was 100%. Adverse events (AEs) were managed successfully, with no occurrence of procedure-related deaths. Liver function test values after PVS-125I were not significantly different than baseline values (P＞0.05). The median TTP was 7.0 months (range: 4.2–9.9 months). In Vp3 PVTT, the TTP was 9.7 months (range: 8.8–10.5 months), and in Vp4 PVTT, the TTP was 4.2 months (range: 2.8–5.6 months). The median OS was 10.0 months (range: 7.0–13.1 months). In Vp3 PVTT, OS was 11.9 months (range: 9.2–14.5 months), and in Vp4 PVTT, OS was 7.2 months (range: 3.8–10.7 months).

Conclusions:
PVS-125I-TACE-S is safe for patients with HCC with PVTT and may extend the TTP and survival of patients with Vp4 PVTT.

Advances in knowledge:
PVS implantation promptly restored flow in the obstructed portal vein, which can reduce the risk of hepatic failure and upper gastrointestinal bleeding. Implantation of iodine-125 seed-strips may directly expose the portal tumor thrombus to radiation and kill cancer cells. Their combined use with TACE-S has a strong scientific rationale.
Giving voice to those directly affected by the COVID-19 pandemic – the experience and reflections of a person with dementia
Authors: Rochford-Brennan Helen , Keogh Fiona 
Published: May 2020

The coronavirus disease 2019 (COVID-19) pandemic presents unprecedented challenges to society. Behind the daily tally of deaths and cases of infection are individuals and families who are experiencing the ultimate consequence of this disease. Every aspect of our lives has been affected and these affects are amplified for those who have to cocoon and have conditions such as dementia. There is little opportunity to directly hear the experience of those ‘vulnerable adults’ who have been self-isolating for many weeks now. This letter takes the form of a reflective conversation with a person living with dementia. Honouring the principles of public and patient involvement (PPI), it is an attempt to give voice to the experience of one of the many thousands of vulnerable people during the COVID-19 pandemic. As well as describing the effect on her daily life, Helen describes what supports would help at this time. While the focus of attention at the moment is rightly on dealing with the effects of the virus in nursing homes, the many thousands of people living with dementia in the community should not be forgotten.
Phonon counting thermometry of an ultracoherent membrane resonator near its motional ground state
Authors: Galinskiy I. , Tsaturyan Y. , Parniak M. , Polzik E. S. 
Published: May 2020

The generation of non-Gaussian quantum states of macroscopic mechanical
objects is key to a number of challenges in quantum information
science, ranging from fundamental tests of decoherence to quantum
communication and sensing. Heralded generation of single-phonon states
of mechanical motion is an attractive way toward this goal, as it is,
in principle, not limited by the object size. Here we demonstrate a
technique that allows for generation and detection of a quantum state
of motion by phonon counting measurements near the ground state of a
1.5 MHz micromechanical oscillator. We detect scattered photons from a
membrane-in-the-middle optomechanical system using an ultra-narrowband
optical filter, and perform Raman-ratio thermometry and second-order
intensity interferometry near the motional ground state (

n
¯

=
0.23
±
0.02

p
h
o
n
o
n
s

). With an effective mass in the
nanogram range, our system lends itself for studies of long-lived
non-Gaussian motional states with some of the heaviest objects to
date.
ADVOKASI BURUH DALAM PEMENUHAN HAK KESELAMATAN DAN KESEHATAN KERJA
Authors: Ramadhan Aroisy 
Published: May 2020

Penelitian ini menjelaskan tentang bagaimana Advokasi SERBUK Indonesia dalam pemenuhan hak keselamatan dan kesehatan kerja dan mengungkapkan tentang hambatan dan tantangan yang dihadapi oleh Federasi SERBUK dalam melakukan advokasi tersebut. Jenis penelitian ini adalah kualitatif dengan menggunakan pendekatan deskriptif. Peneliti mengkumpulkan data menggunakan metode observasi, wawancara, dan dokumentasi. Analisis data yang dilakukan menggunakan reduksi data, penyajian data, dan penarikan kesimpulan. Uji validitas data dalam penelitian ini menggunakan metode keabsahan data triangulasi, dimana metode ini digunakan sebagai pembanding antara hasil wawancara dengan dokumen yang diperoleh peneliti di lapangan. Dalam menjalankan advokasi sebagai serikat buruh menggunakan dua metode advokasi, pertama yaitu advokasi kelas yang dilakukan oleh Federasi SERBUK Indonesia dengan mewakili suatu kelompok dalam penelitian ini adalah kaum buruh yang diperjuangkan untuk mendapatkan hak K3. Kedua adalah advokasi kasus yang dilakukan dengan cara menyelesaikan permasalahan kasus individu yang dihadapi buruh dengan bantuan serikat. Hambatan yang dialami oleh Federasi SERBUK yaitu anggota yang kurang kompeten, pasif dan, tidak prinsipil. Sedangkan tantangan yang dihadapi oleh SERBUK adalah tindak intimidasi dari perusahaan, dan stigma kawan buruh lain yang memandang sebelah mata kepada serikat yang dekat dengan partai.Kata Kunci : Advokasi, Serikat Buruh, Keselamatan dan Kesehatan Kerja
PENGARUH PENERIMAAN ORANG TUA TERHADAP PERKEMBANGAN EMOSI ANAK DIFABEL
Authors: Zahroh Shofiyatuz 
Published: May 2020

Anak difabel adalah anak yang memiliki kemampuan berbeda dari anak pada umunya, namun kenyataannya masyarakat masih memandang difabel sebagai anak yang “cacat”. Sehingga, hal ini berpengaruh pada sikap orang tua terhadap anak difabel. Sikap orang tua yang ditunjukkan terhadap anak difabel ada yang menerima dan ada yang menolak kehadiran anak difabel, yang merupakan bagian dari reaksi psikologis orang tua. Permasalahan yang diteliti adalah apakah penerimaan orang tua mempengaruhi perkembangan emosi anak difabel. Kemudian, dari permasalahan tersebut, ditentukan hipotesis kerja yaitu ada pengaruh antara penerimaan orang tua terhadap perkembangan emosi anak difabel di Desa Bragung. Untuk menelaah masalah tersebut, digunakan variabel penerimaan orang tua (X) sebagai variabel bebas dan perkembangan emosi anak difabel (Y) sebagai variable terikat. Populasi dalam penelitian ini adalah semua orang tua yang memiliki anak difabel di Desa Bragung. Sedangkan teknik sampling yang digunakan adalah sampel populasi yaitu, orang tua dengan anak difabel yang berjumlah 40 orang. Metode pengumpulan data yang digunakan adalah skala penerimaan orang tua dan skala perkembangan emosi anak difabel. Hasil dari penelitian ini yaitu, tingkat penerimaan orang tua adalah 47,5% berada pada kategori rendah. Sedangkan tingkat perkembangan emosi anak difabel (a) tunanetra 45,5% berada pada kategori rendah, (b) tunarungu 33,33% berada pada kategori seimbang, (c) tunagrahita 60% berada pada kategori rendah, (d) tunadaksa 60% berada pada kategori rendah. Analisis data penelitian ini menggunakan bantuan komputer program SPSS 16.0 for windows yang menunjukkan korelasi positif dan signifikan antara penerimaan orang tua dengan perkembangan emosi anak difabel (a) tunanetra 0,723, (b) tunarungu 0,706, (c) tunagrahita 0,780, (d) tunadaksa 0,665. Hal ini menunjukkan bahwa Ha diterima karena Rhitung > Rtabel. Kata kunci: Penerimaan orang tua, perkembangan emosi, anak difabel
Oblicza Ireny Sendlerowej. Wizerunek Sprawiedliwej wśród Narodów Świata w relacjach uratowanych przez nią dzieci oraz w debacie publicznej po roku 2000
Authors: SUSZKIEWICZ KATARZYNA 
Published: May 2020

Artykuł ma na celu analizowanie przemian wizerunku Ireny Sendlerowej – Sprawiedliwej wśród Narodów Świata, działaczki Rady Pomocy Żydom „Żegota”. W pracy uwypuklone zostały dwa oblicza Sendlerowej: matczyne, takie, jakie zachowały w pamięci uratowane przez nią dzieci oraz heroiczne – wykreowane w przestrzeni publicznej po roku 2000. W artykule jej postać ukazana została na tle przemian w postrzeganiu relacji polsko-żydowskich w Polsce.