bluuebunny/crossref_metadata_2025_split huggingface dataset:
La dualidad en el relato La noche boca arriba de Julio Cortázar desde la gramática pedagógica
Authors: Paulo Selvi Isabel Amparo 
Published: December 2020

La enseñanza de la gramática en el aula de ELE no está exenta de controversia y de dificultades. El estudiante de ELE necesita una instrucción formal, una enseñanza gramatical explícita que le permita interiorizar las normas y convertir ese conocimiento explícito en implícito.
El relato de Cortázar propone una transgresión temporal (un juego con analepsis y prolepsis), dentro de una estructura narrativa que se desarrolla a través de dos deícticos temporales -aquí / allá- y una compleja red de morfología verbal. Este artículo ofrece actividades realizadas desde la perspectiva de una gramática pedagógica, en la que el alumno participa activamente en su proceso de aprendizaje, para lograr una mejor comprensión de los tiempos verbales, uno de los problemas gramaticales recurrentes en el aula de ELE.
Chemical Composition of Serendipity Berry (Dioscoreophyllum cumminsii) and Miracle Fruit (Thaumatococcus daniellii)
Authors: Ojo A. , Enujiugha V. N. , Omogie H. N. Ayo- , Abiodun O. A. 
Published: December 2020

Aims: To determine the chemical composition of serendipity berry (Dioscoreophyllum cumminsii) and miracle fruit (Thaumatococcus daniellii).
Study Design: The mean and standard deviation of the data obtained were analyzed.
Place and Duration of Study: Samples were prepared in Department of Food Science and Technology, Osun State Polytechnic, between November 2018 and December 2019.
Methodology: Chemical properties of two natural sweeteners namely the miracle fruit (Thaumatococcus danielli) and serendipity berry (Dioscoreophyllum cumminsii) were studied in this work. The fresh fruits were obtained from a farm, sorted, washed and the tissues were scraped, dried in the oven at 45°C for 12 hrs, milled and packed in airtight plastic containers. Proximate, vitamins and amino acid contents of the sweeteners were determined.
Results: The results revealed that the protein contents of miracle fruit and serendipity berry were 75.57% and 62.54% respectively. Moisture contents of the sweeteners ranged from 56.95-58.33% while ash contents ranged from 19.33-22.90%. The sweeteners had low carbohydrate and lipid contents. Crude fiber was not detected in miracle fruit but serendipity berry had crude fibre of 5.38%. The fruits had β-carotene contents ranging from 8.44 mg/100 g and 23.00 mg/100 g, vitamin C (20.40 mg/100 g and 22.01 mg/100 g) and vitamin D (17.02 mg/100 g and 19.02 mg/100 g) in miracle fruit and serendipity berry respectively. However, low values were recorded for vitamin E 0.55 mg/100 g and 0.89 mg/100 g in miracle fruit and serendipity berry respectively. The fruits had appreciable amount of essential amino acid which was above 50% of the total amino acid content. Miracle fruit had 51.96% and serendipity berry had 58.07% of the essential amino acid. Aromatic essential amino were 10.78 and 12.79% in miracle fruits and serendipity respectively.
Conclusion: This study showed that the two natural sweeteners are good source of essential nutrients and could be used as food supplements in our diet.
Challenges in the Process of Development and Maintenance of a Modern Bulgarian Food Composition Database: FAO’s Project – Real Achievements
Authors: Gyurova Desislava K. 
Published: December 2020

High-quality food composition data should be representative of national food habits and consumption patterns. They should be generated according to established standard international guidelines so that they are comparable and reliable. Well-designed tables and databases should include a good selection of food components and majority of commonly consumed foods. However, this is often not the case as many tables only include raw foods and a small number of nutrients while processed and fortified foods are lacking.
The aim of this review is to focus on the importance of national food composition databases; to show the current status of the problem in Bulgaria; and priorities in the development of a new modern database; in order to attract the attention of stakeholders (government institutions, universities, research institutes, manufacturers and independent specialized laboratories).
Development Liquid and Solid Self Microemulsifying Drug Delivery System (L-SMEDDS and S-SMEDDS) Containing Black Seed Oil (Nigella sativa L.)
Authors: Priani Sani Ega , Maulidina Septiani Siti , Darusman Fitrianti 
Published: December 2020

Aims: The aims of this research were to develop and characterize liquid and solid micro emulsifying drug delivery system (L-SMEDDS and S-SMEDDS) containing black seed oil.
Study Design: Experimental Research Design (laboratory).
Place and Duration of Study: The study was conducted at research laboratory of pharmacy department UNISBA, between August 2018- August 2019.
Methodology: The optimization of L-SMEDDS was carried out using various comparison of oil, surfactant, and cosurfactant. All formulations were evaluated for percent transmittance, emulsification time, dispersibility, robustness, and thermodynamic stability. The best formula of L-SMEDSS was evaluated for globule size distribution and converted to S-SMEDDS by spray drying method using aerosil 200 as adsorbent. S-SMEDDS were evaluated for organoleptic, flowability, compressibility, emulsification time, dispersibility, robustness and surface morphology.
Results: The best formula of L-SMEDDS contains tween 80 as a surfactant and PEG 400 as cosurfactant (2:1) with a ratio of oil and Smix (2:8). The L-SMEDDS preparation meets the requirement of percent transmittance (95.77%), emulsification time (37.67 seconds), grade A of dispersibility, stable of robustness and thermodynamics study with the average of globule size was 231 nm. S-SMEDDS preparation meets the requirement of the moisture content, flowability, emulsification time, and stable on robustness testing with a spherical shape.
Conclusion: L-SMEDDS and S-SMEDDS of black seed oil have been developed and have good physical characteristics and stability.
Recovered memories of child abuse outside of therapy
Authors: Dodier Olivier , Patihis Lawrence 
Published: December 2020

SummaryWe examined the incidence of recovered memories of child abuse in a large French general public sample (N = 3346). Of the 905 (27% of total sample) who reported having memories of abuse, 211 (23%) reported recovered memories of child abuse that they had no previous memory of, with 82 of these (9% of the 905) reporting that they did not know they were abused beforehand. Ninety percent of the latter reported having recovered their memories when not in a therapy at the time. Those who reported recovered memories outside of therapy often reported discussions with peers and/or media exposure related to childhood abuse that occurred either before or during memory recovery. Our prevalence results are discussed in light of the hypothesis that many recovered memories are in fact reinterpreted continuous memories. The findings on context are discussed in relation to the work on the malleability of memory.
Review of Stimulated Raman Scattering Microscopy Techniques and Applications in the Biosciences
Authors: Li Yanping , Shen Binglin , Li Shaowei , Zhao Yihua , Qu Junle , Liu Liwei 
Published: December 2020

AbstractStimulated Raman scattering (SRS) microscopy is a nonlinear optical imaging method for visualizing chemical content based on molecular vibrational bonds. Featuring high speed, high resolution, high sensitivity, high accuracy, and 3D sectioning, SRS microscopy has made tremendous progress toward biochemical information acquisition, cellular function investigation, and label‐free medical diagnosis in the biosciences. In this review, the principle of SRS, system design, and data analysis are introduced, and the current innovations of the SRS system are reviewed. In particular, combined with various bio‐orthogonal Raman tags, the applications of SRS microscopy in cell metabolism, tumor diagnosis, neuroscience, drug tracking, and microbial detection are briefly examined. The future prospects for SRS microscopy are also shared.
Wearable Sensors‐Enabled Human–Machine Interaction Systems: From Design to Application
Authors: Yin Ruiyang , Wang Depeng , Zhao Shufang , Lou Zheng , Shen Guozhen 
Published: December 2020

AbstractIn comparison to traditional bulky and rigid electronic devices, the human–machine interaction (HMI) system with flexible and wearable components is an inevitable future trend. To achieve effective, intuitive, and seamless manipulation of high‐performance wearable HMI systems, it is important to develop effective strategies for designing material microstructures on flexible sensors and electric devices with excellent mechanical flexibility and stretchability. The real‐time acquisition of human physiology and surrounding signals through accurate and flexible sensors is the basis of wearable HMIs. Herein, the construction of a wearable HMI system that utilizes sensors, communication modes, and actuators is reviewed. The mechanisms and strategies for designing various flexible sensors based on different mechanisms are analyzed and discussed. The functional mechanism, material selection, and novel design strategies of each part are summarized in detail. The different communication modes in interactive systems and the manufacturing technology of soft machines are also introduced. Additionally, the most advanced applications of wearable HMI systems in intelligent identification and security, interactive controls for robots, augmented reality, and virtual reality have been highlighted. The review concludes with an overview of the remaining key challenges and several ideas regarding the further improvement of wearable HMI systems.
The evolving ethics of analysis, publication, and transparency in applied economics
Authors: Lybbert Travis J. , Buccola Steven T. 
Published: December 2020

AbstractCredible economic research demands discipline and defensible modeling assumptions—both theoretical and empirical—but incentives to strategically shape findings (e.g., p‐hack) can be strong. We examine recent waves of empiricism in economics and the ethical concerns and responses they prompted. Statistical abuses that opportunistically search for significance are often inseparable from conceptual abuses of opportunistic model identification (i.e., p‐hacking writ large). We compare neoclassical with positivist hacking proclivities and explore associated implications for empirical analysis and peer review. Drawing on our experiences, 25 years apart, as AJAE editors we reflect on efforts to evaluate research quality and enhance research transparency.
Self‐assembly and tunable optical properties of intramolecular charge transfer molecules
Authors: Shen Han , Li Yongjun , Li Yuliang 
Published: December 2020

AbstractCrystalline aggregates formed by self‐assembly of organic small molecules have aroused intensive attention in many fields due to their controllable morphologies and functionalization. The advantages of intramolecular charge transfer (ICT) compounds endow them with the ability to self‐assemble into diverse dimensional crystalline microstructures, as potential candidates for advanced materials and smart miniatures in practical applications. In this review, the recent progresses of self‐assembled microstructures of functional ICT molecules in our group for a decade are summarized. The factors influencing the fabrication of the microstructures in solvent‐involved processes are fully discussed. Distinct optical properties induced by self‐assembly behaviors are also depicted. We try to give an outlook of structure‐property relationships in functional microstructure engineering and clarify the crucial issues to be addressed in the future scientific research.
DNA nanostructure‐encoded fluorescent barcodes
Authors: Zhai Tingting , Li Qian , Shen Jianlei , Li Jiang , Fan Chunhai 
Published: December 2020

AbstractIdentification and differentiation of various bioanalytes with high spatial and temporal resolution have spawned fluorescent barcode‐based detection and imaging. DNA nanostructures with excellent structure programmability, addressability, and near‐atomic structure accuracy have emerged as a versatile platform to develop fluorescent barcodes through finely controlled dye numbers, relative distances, and compositions. A variety of DNA fluorescent barcodes with distinguishable spectral colors, geometries and digitized fluorescence intensities have been constructed and favorably implemented in the field of bioimaging, multiplex bioassay, and information security. In this review, we first summarize the state of the art of self‐assembled DNA nanostructures. Next, the utilization of DNA nanostructure to develop fluorescent barcodes and the photophysical properties of DNA‐templated fluorophores are reviewed. Finally, the applications of DNA fluorescent barcodes for biosensing and imaging, and the challenges and outlook of DNA nanostructure‐engineered fluorescent barcodes are discussed.
Hyperbolicity of reaction‐transport processes
Authors: Ozorio Cassol Guilherme , Dubljevic Stevan 
Published: December 2020

AbstractIn this manuscript, common chemical engineering transport‐reaction systems are modeled by taking into consideration the inertia in the transport phenomena, leading to hyperbolic partial differential equations (PDEs), which have finite speed of propagation. The findings provide the derivation of the hyperbolic transport‐reaction PDEs and a direct comparison with their corresponding dissipative parabolic PDEs. The stability analysis of the dynamical systems is considered and complemented by numerical simulations for typical processes, such as the heat diffusion in a slab, transport‐reaction inside a chemical reactor, and a phase change problem. The results demonstrate the effects associated with the modeling and/or limits of the approximation used in the derivation and application of the hyperbolic PDE for transport‐reaction systems, and the difference between the dynamics of this type of equation and the generally used parabolic PDEs.
Newborn anthropometry, maternal capital, and altitude in the highland population from the province of Jujuy, Argentina
Authors: Martínez Jorge I. , Figueroa Marcelo I. , Alfaro Gómez Emma L. , Dipierri José E. 
Published: December 2020

AbstractObjectiveTo analyze variability in newborn (NB) anthropometry among Jujenean NBs as a function of geographic altitude (500 m to ≈4000 masl), maternal anthropometry and other maternal characteristics within the maternal capital framework.Materials and methodsData obtained from 41,371 mother/child pairs recorded in the Jujuy Perinatal Information System (SIP) between 2009 and 2014, including: NB and maternal weight, length/height and BMI; gestational age (corrected); maternal age, educational level, nutritional status, and marital status; birth interval; and planned pregnancy. Based on the declared place of residence, the prevalence of unsatisfied basic needs (% UBN) was determined and the data was split into two altitudinal groups: highlands (HL, >2500 masl) and lowlands (LL, <2500 masl). ANOVA, Chi‐squared and Pearson tests were applied as needed. Statistical associations between the response variables—NB weight, length and BMI—and maternal and environmental variables were tested using a Generalized Additive Mixed Model (GAMM).ResultsAll NB and maternal anthropometric variables were lower in HL compared to LL; they also presented negative correlations with altitude, except NB length. Apart from gestational age and birth interval, HL and LL presented statistically significant differences in all study variables. GAMM results showed that maternal anthropometry was the main influence on NB weight and length.DiscussionOf all the maternal capital features examined, only maternal anthropometric variables were found to protect offspring against the negative impact of HL environments.
Techno‐economic assessment of heterotrophic microalgae biodiesel production integrated with a sugarcane bio‐refinery
Authors: Sano Coelho Renato , Cuellar Maria C. , Franco Telma T. , van der Wielen Luuk A. M. 
Published: December 2020

AbstractThe use of diesel fuel in crop and transportation operations is responsible for one third of the carbon emissions in sugarcane biorefineries. A possible solution is to replace it with biodiesel from lipids, directly produced from sugarcane by highly productive heterotrophic microalgae. In this study a heterotrophic microalgae biodiesel plant, integrated with a typical Brazilian sugarcane bio‐refinery, was designed and evaluated. Molasses, steam, and electricity from sugarcane processing were used as inputs for microalgae production. For a non‐integrated plant, the production cost of the microalgae biodiesel was estimated at 2.51 and 2.27 $/liter for fed‐batch and continuous processes, respectively. Equipment for cultivation and carbon sources was the highest cost affecting the financial feasibility of the proposed design. For the integrated plant, at present ethanol and biodiesel selling prices, the profitability would be lower than a first‐generation sugarcane bio‐refinery using fossil diesel fuel for its operations. However, the CO2 emissions would be reduced by up to 50 000 × 103 kg per year at a cost of $83 10−3 kg−1 CO2‐eq. If carbon credits are considered, the process becomes economically profitable even at present fuel prices. © 2020 The Authors. Biofuels, Bioproducts, and Biorefining published by Society of Chemical Industry and John Wiley & Sons, Ltd
Role of coxsackie‐adenovirus receptor in cardiac development and pathogenesis of congenital heart disease
Authors: Sharma Vipul , Perry Daniel J. , Eghtesady Pirooz 
Published: December 2020

AbstractThe coxsackie‐adenovirus receptor (CAR) is a cell surface transmembrane protein originally recognized for its role as a binding site for coxsackie‐ and adeno‐viruses. As such, it is believed to play an important role in pathogenesis of myocarditis. Other studies have suggested that CAR also plays an important role in embryonic development, which is not surprising given the strong expression of the receptor in heart, brain, liver, pancreas, kidney, small intestine, and various epithelia during development. A number of studies have looked at downregulation and upregulation of CAR and have confirmed the central role of CAR during critical periods of development. These studies all demonstrated embryonic lethality with variable phenotypes: electrophysiological abnormalities, cardiac structural deformations, and extracardiac abnormalities, such as lymphatic malformations. The purpose of this review is to summarize the existing literature about CAR and formulate some questions for future studies, with an emphasis on the role of CAR during embryonic heart development.
Microscopy‐based assay for semi‐quantitative detection of SARS‐CoV‐2 specific antibodies in human sera
Authors: Pape Constantin , Remme Roman , Wolny Adrian , Olberg Sylvia , Wolf Steffen , Cerrone Lorenzo , Cortese Mirko , Klaus Severina , Lucic Bojana , Ullrich Stephanie , Anders‐Össwein Maria , Wolf Stefanie , Cerikan Berati , Neufeldt Christopher J. , Ganter Markus , Schnitzler Paul , Merle Uta , Lusic Marina , Boulant Steeve , Stanifer Megan , Bartenschlager Ralf , Hamprecht Fred A. , Kreshuk Anna , Tischer Christian , Kräusslich Hans‐Georg , Müller Barbara , Laketa Vibor 
Published: December 2020

AbstractEmergence of the novel pathogenic coronavirus SARS‐CoV‐2 and its rapid pandemic spread presents challenges that demand immediate attention. Here, we describe the development of a semi‐quantitative high‐content microscopy‐based assay for detection of three major classes (IgG, IgA, and IgM) of SARS‐CoV‐2 specific antibodies in human samples. The possibility to detect antibodies against the entire viral proteome together with a robust semi‐automated image analysis workflow resulted in specific, sensitive and unbiased assay that complements the portfolio of SARS‐CoV‐2 serological assays. Sensitive, specific and quantitative serological assays are urgently needed for a better understanding of humoral immune response against the virus as a basis for developing public health strategies to control viral spread. The procedure described here has been used for clinical studies and provides a general framework for the application of quantitative high‐throughput microscopy to rapidly develop serological assays for emerging virus infections.
Fluorimetric determination of the enantiomers of vigabatrin, an antiepileptic drug, by reversed‐phase HPLC with a novel diastereomer derivatization reagent
Authors: Uekusa Shusuke , Onozato Mayu , Sakamoto Tatsuya , Umino Maho , Ichiba Hideaki , Fukushima Takeshi 
Published: December 2020

AbstractHerein, determination of an antiepileptic drug, (±)‐vigabatrin (VB), was performed by reversed‐phase HPLC with fluorimetric detection using a newly designed and synthesized fluorescence derivatization reagent, 2,5‐dioxopyrrolidin‐1‐yl (4‐{[(2‐nitrophenyl)sulfonyl]oxy}‐6‐(3‐oxomorpholino)quinoline‐2‐carbonyl)prolinate [Ns‐MOK‐(R)‐ or (S)‐Pro‐OSu]. During the derivatization of VB with Ns‐MOK‐(R)‐Pro‐OSu at 60°C, the nosyl (Ns) group, which was introduced to protect a phenolic hydroxy group, was released within 30 min to produce MOK‐(R)‐Pro‐VB, which was detected fluorimetrically at 448 nm with an excitation wavelength of 333 nm. The VB enantiomers were separated on an octadecylsilica (ODS) column with a resolution value of 5.57, because Ns‐MOK‐(R)‐Pro‐OSu bears an optically active D‐proline structure. A complete separation of MOK‐(R)‐Pro‐(R)‐ and ‐(S)‐VB enantiomers was achieved on the ODS column within 40 min using stepwise gradient elution, and the detection limits were ~0.80 and 0.37 pmol on the column, respectively. The proposed HPLC with fluorimetric detection method was successfully used for determining VB enantiomers in VB‐spiked human serum following solid‐phase extraction with an anion‐exchange cartridge.
A review of business models for decentralised renewable energy projects
Authors: Piterou Athena , Coles Anne‐Marie 
Published: December 2020

AbstractThe diffusion of renewable energy technologies has often been suggested as a means to reduce the emission of greenhouse gases, but emphasis tends to be placed on large scale projects. Adoption of renewable energy at the local level provides opportunities for both distributed energy schemes and domestic microgeneration. However, alternative models of ownership, governance and operation are not well developed. Locally managed energy solutions need to respond to varied end users' requirements to ensure that needs are met, so understanding of different types of end users is a prerequisite to the development of robust business models. This paper presents a review of existing models of decentralised energy generation in which actors such as community groups, energy cooperatives, charities and municipalities participate as owners and coproducers. End users can become involved in the design, development and delivery of energy services in a variety of ways. The focus is active user engagement through coconstruction, coproduction and coprovision of energy services. The following categories will be reviewed with reference to current understandings of both sustainable entrepreneurship and social enterprise: (a) energy service companies (ESCos) as commercial actors that undertake management of these projects, (b) energy cooperatives and (c) municipal energy. This analysis is used to reflect on and refine understanding of the relationship between technical, financial and operational constructs in models of decentralised energy generation which can contribute to social and environmental gains.