bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional parameters indicative of Mild Cognitive Impairment: a Systematic Review using Instrumented Kinematic Assessment
Authors: Fuentes-Abolafio Iván José , Stubbs Brendon , Pérez-Belmonte Luis Miguel , Bernal-López María Rosa , Gómez-Huelgas Ricardo , Vargas Antonio Cuesta 
Published: January 2020

Abstract

BackgroundSubjects with mild cognitive impairment (MCI) experience alterations of functional parameters, such as impaired balance or gait. The current systematic review set out to investigate whether functional objective performance may predict a future risk of MCI; to compare functional objective parameters in confirmed MCI people with a control group; and to assess longitudinal changes in these parameters after different physical interventions.MethodsA systematic review of relevant literature was conducted. Literature were searched in PubMed, AMED, CINAHL, EMBASE, PEDro and Web of Science as well as grey literature databases. Cohort studies and Randimized Controlled Trials (RCTs) were included. Quality of reviewed studies were assessed independently by reviewers using quality assessment checklists.ResultsFifteen studies met inclusion criteria including mild cognitive impairment people. Results from RCTs suggested that gait speed, gait variability and balance may be improved by different physical interventions. Cohort studies showed that gait speed, gait variability and gait symmetry, especially in Dual Task (DT) conditions, were parameters impaired in confirmed MCI patients in comparison with a Control Gorup. Furthermore, cohort studies suggested that gait variability could be a predictor of MCI. However, RCTs showed an unclear risk of bias and all studies included in this systematic review had a low quality of evidence.ConclusionsExisting studies suggest that gait variability may predict incident MCI, moreover different gait parameters, especially during DT conditions, could be impaired in MCI. These parameters could be improved by some interventions. Further studies are required to refute our findings.
Postoperative visits by dedicated anesthesiologists in patients with elevated troponin: a retrospective cohort study evaluating postoperative care utility and early detection of complications
Authors: Akkermans Annemarie , Vernooij Lisette M. , Klei Wilton A. van , Waes Judith A. van 
Published: January 2020

Abstract
Background An elevated cardiac troponin level after noncardiac surgery is associated with both morbidity and mortality. Guidelines suggest routine troponin monitoring in high-risk patients. We implemented a dedicated anesthesia team to conduct follow-up on patients with postoperative troponin elevation. We hypothesized that these visits would facilitate early detection of complications. Therefore, the aim of this study was to evaluate the effect of postoperative visits by dedicated anesthesiologists on early detection of complications and care utility. Methods This retrospective observational study included patients aged ≥60 years with an elevated troponin within the first three days after noncardiac surgery. Troponin elevation was detected by routine biomarker monitoring. The primary outcome was early detected myocardial infarctions by the dedicated anesthesiologist. Other outcomes were overall detected complications, additional diagnostic tests and treatment advised by the anesthesiologist, consultation of another medical specialist, and advised postoperative follow-up at the outpatient cardiac clinic within one week after surgery. Results Of the 811 patients, 509 (63%) received a postoperative consultation by the anesthesiologist. Anesthesiologists were involved in the early detection of 59% of all myocardial infarctions and in 12% of all complications. Besides cardiac ischemia, patients were also often diagnosed with noncardiac complications, including respiratory failure (8.9%), pneumonia (13.2%) and acute kidney injury (17.5%) within one week after surgery. In 75% of patients, anesthesiologists ordered additional diagnostics, most frequently existing of electrocardiograms and additional cardiac enzyme testing. Additionally, change in treatment was advised, most often a medication change, in 16% of patients. Conclusions Standard consultation of a dedicated anesthesiologist resulted in an early detection of 59% of all myocardial infarctions and involved a change in treatment in a considerable number of patients with postoperative troponin elevation. Whether this may improve patient outcomes remains to be elucidated.
Hospital Managers Skills Required and Onward Challenges: A Qualitative Study
Authors: Moradi Farideh , ziapour arash , Abbas Jaffar , Baharirad Nadya , Soroush Ali 
Published: January 2020

Abstract
Aims: The qualification of managers in terms of management skills is one of the most important factors in the continuous success of each organization and utilizing such skills can have a positive contribution in the effectiveness of the organization while improving the performance of the employees in line with the objectives and goals of the organization. The main objective of the current study was to explore the necessary skills and the challenges of hospital managers from the point of view of managers at different levels of a hospital. Methods: This study is a qualitative one where the statistical population includes the mid-level and senior-level managers of the hospital. The sample size was 22 individuals. The interviews were analyzed by a MAXQDA software application after transcription. Results This study includes 5 main themes and 15 secondary themes. The strategic skill, the perceptive skill, the human relation skill, work experience, and personal characteristics were among the skills necessary for hospital managers. Some of the challenges facing the hospital managers included rapid changes in the policies, the limitations of financial resources, and lack of proportion between the educational and occupational spheres. Conclusion: Because of their existential philosophy and differences with other service sectors, managing hospitals poses a particular sensitivity. In this regard, the role of the hospital manager is very important. Therefore, in order to meet the satisfaction of those receiving services, decision makers, and policy makers must think twice when selecting and appointing hospital managers and evaluate and appraise this group in terms of abilities and skills necessary for managing such an important service section.
The Prevalence of Type D Personality and Correlations between Medication Self-Efficacy and Self-Care Behavior in Patients with Hypertension
Authors: Wongsuriyanan Chayanee , Phattharayuttawat Sucheera , Ratta-apha Woraphat 
Published: January 2020

Abstract
Background: Type D personality is a combination of 2 traits which are negative affectivity and social inhibition. In health care situation, type D patients are more likely to have non-medication adherence, pessimistic about their ability to cope with illness and believe that it will be long-lasting which lead them to present worse health outcomes. This study aimed to examine the prevalence of type D personality and associations among medication self-efficacy and self-care behaviors in patients with hypertension.
Methods: This is a descriptive cross-sectional study. Patients with hypertension (n = 383) who attended a primary care unit were recruited. Volunteering participants completed the Type D-Scale (DS14) questionnaire for the evaluation of the prevalence of type D personality. To evaluate medication self-efficacy and self-care behavior, Self-efficacy for Appropriate Medication Use Scale Thai version and Self-care behaviors scale for patients with hypertension were employed. Descriptive statistics, t-test, and Pearson’s correlations were used in data analysis.
Results: Fifty-six participants (14.6%) were classified with type D personality (26 males and 30 females). A positive relationship between medication self-efficacy and self-care behavior was found (r = 0.294, p < 0.01). In contrast, type D personality had a negative association with medication self-efficacy and self-care behavior (r = -0.251, r = -0.138, p < 0.01).
Conclusion: Compare to the previous studies, the present study illustrated quite lower prevalence of type D personality. Type D personality is a psychological health risk factor which negatively affects health both directly and indirectly, especially self-efficacy and self-care behavior. Even just one of the two type D personality traits can lead to a similar detrimental result. Positive relationship between medication self-efficacy and self-care behavior can be applied to develop health promotion programs for patient with hypertension.
Identifying NAHR mechanism between two distinct Alu elements through breakpoint junction mapping by NGS
Authors: Filho Gil Monteiro Novo , Carvalho Gleyson Francisco da Silva , Nascimento Amom Mendes , Montenegro Marilia Moreira , Damasceno Julian Gabriel , Zanardo Évelin Aline , Chehimi Samar Nasser , Oliveira Yanca Gasparini , Dias Alexandre Torchio , Kim Chong Ae , Kulikowski Leslie Domenici 
Published: January 2020

Abstract
Background:
Genomic rearrangements encompass deletions, duplications, inversions, insertions and translocations and may be the cause of several genetic diseases. One of the most frequent mechanisms that generates these rearrangements is the Non-Allelic Homologous Recombination (NAHR). They are caused by a misalignment between regions of high level of similarity, like Low Copy Repeats (LCRs) and Alu sequences. We aimed to sequence the breakpoint of a patient with a single deletion on chromosome 22q13.2 in order to understand the genomic structure of the region involved as well as elucidate the mechanism behind this rearrangement. Investigating breakpoints are of the utmost importance in the understanding the influence of the genomic architecture in clinical assays.
Results:
We flanked the breakpoint detected by array and then we captured the regions using Illumina Nextera Rapid Capture Custom to sequence with Illumina MiSeq. We found a chimeric read on Chr22:41,026,090, setting a 624,688 bp deletion on Chr22:41,026,112-41,650,780 (hg19).
This deletion merges the intronic region of MKL1 and RANGAP1 genes, on two different Alu sequences ( AluSx and AluY, respectively ).
Conclusions: The sequence of the breakpoint reveals that Alu elements are an important characteristic of the human genome on generating rearrangements.
ApoE and apoC-III-defined HDL subtypes: A descriptive study of their LCAT and CETP content and activity
Authors: Amaya-Montoya Mateo , Pinzón-Cortés Jairo A , Silva-Bermúdez Lina S , Ruiz-Manco Daniel , Perez-Matos Maria C , Jimenez-Mora Mario A , Mendivil Carlos O 
Published: January 2020

Abstract
Background High-density lipoproteins (HDL) in plasma are strongly and negatively associated with cardiovascular risk, yet interventions to raise HDL have not improved cardiovascular outcomes. HDL functionality and heterogeneity may hold the clue to this paradox. The apolipoprotein composition of HDL may be an important determinant of their functionality. Lecithin-cholesterol acyl transferase (LCAT) and cholesterol-ester transfer protein (CETP) are key enzymes for HDL-mediated reverse cholesterol transport. We assessed the distribution and activity of LCAT and CETP in HDL subspecies defined by their content of apolipoproteins E (apoE) and C-III (apoC-III) in humans. Methods We isolated in adult humans of both sexes (mean age 55.6, BMI 26.9 Kg/m2, HbA1c 5.4%), four subspecies of HDL containing respectively: No apoE and no apoC-III (E-C-), apoE but not apoC-III (E+C-), apoC-III but no apoE (E-C+) and both apoE and apoC-III (E+C+). In each HDL subspecies, we measured LCAT and CETP concentration and activity using immunoenzymatic and fluorometric methods. Additionally, we determined the size distribution of HDL in each apolipoprotein-defined fraction using non-denaturing electrophoresis and anti-ApoA-I western blot. Results Similar to previous studies, HDL in the E-C- fraction was the predominant subtype. The size distribution of HDL was very similar across all four apolipoprotein-defined fractions. LCAT was most abundant in E-C- HDL (3.58 mg/mL, 59.6 % of plasma LCAT mass), while HDL with apoE or apoC-III had much less LCAT (19.8%, 12.2% and 8.37% of plasma LCAT respectively for E+C-, E-C+ and E+C+). Despite a much lower LCAT mass, LCAT activity in E+C- HDL was comparable to that in E-C- HDL. Both CETP mass and CETP activity showed only slight variations across HDL subspecies. There was an inverse correlation between plasma LCAT activity and both E-C+ pre-beta HDL (r=-0.55, p=0.017) and E-C- alpha 1 HDL (r=-0.49, p=0.041). Conversely, there was a direct correlation between E-C+ alpha 1 HDL and CETP activity in plasma (r=0.52, p=0.025). Conclusions Our results suggest that LCAT activity in humans is influenced by the presence of small interchangeable apolipoproteins. The presence of apoE in small HDL is correlated with increased LCAT activity and esterification of plasma cholesterol.
Antimicrobial, antioxidant and anti-EBV activities of olive leaf (Olea Europea) extracts from Tunisia
Authors: Gargouri Bochra , Amor Ichrak Ben , Tlili Khaoula , Kallel Imen , Attia Hammadi , Lassoued Saloua 
Published: January 2020

Abstract
Background: Olive tree leaves ( Olea europaea ) are widely used in traditional medicine in the Mediterranean Region. Interest in the olive leaf and its chemical constituents has recently been increasing. Its benefits, however, have been known for centuries, and it has been traditionally used to prevent and treat different diseases. The aim of this study was the determination of antimicrobial, antioxidant activities and anti-EBV effects of olive leaves. Methods : The present study was focused on extraction of leaves of olea europea cultivated and wild type from two different geographical tunisian zone: Sfax and El Kef, and the determination of antimicrobial activities against Gram- and Gram+ bacteria and fungi. Olive leaves was analyzed for antioxidant power in chemical system by the DPPH test and the chemiluminescence and in biological system by lipid peroxydation tests (MDA and DC) in Raji cells lines. The antiviral (anti-EBV) effects of olive leaves were assessed using indirect immunofluorescence technique. Results: The antioxidant effect was studied by chemiluminescence where a significant decrease on reactive oxygen species production was observed after leaves olive extract treatment. Antioxidant activities were studied by direct reactive oxyden species assay using chemical systems. The results very interesting for both wild type and cultivated in the two regions since we obtained IC50s of the order of 20.79 μg / ml (cultivated sfax) with DPPH scavening radical. The best result obtained when used olive leaves extract cultivated from Sfax. Our results showed a protection against oxidative stress, highlighted by a significant decrease in MDA and DC levels (p <0.05). Also, a significant antiviral effect of leaves of olive cultivated in Sfax against Epstein-Barr virus (EBV) was determined. Conclusion: The olive leaves extracts analyzed in this work showed a potent antimicrobial activity, an antioxidant activity was expressed by a significant decrease in the production of ERO in the Raji cell line and an anti-EBV effect.
Transcatheter Patent Foramen Ovale Closure Guided Only by Transesophageal Echocardiography Without fluoroscopy
Authors: Zhao Tianli , Wu Qin , Ruge Hendrik , Lange Rüdiger , Yang Yifeng , Jiang Zheng , Zhang Weizhi , Jin Wancun , Bu Haisong , hu shijun 
Published: January 2020

Abstract
Background Standby of transesophageal echocardiography (TEE) is necessary for any PFO closure in case of some cases with complicated anatomy of patent foramen ovale (PFO). The safety and effectiveness of Transcatheter PFO closure guided only by TEE navigation without fluoroscopy is unclear.Methods From 2017.06 to 2019.11, we included 38 patients who were recommended for PFO closure by the department of neurology at our hospital. The procedure was performed in a regular operating room by TEE navigation without fluoroscopy. Follow-up was given at 1st month, 3rd month, 6th month, 1st year and 2nd year after operation for each patient.Results All 38 patients were successfully performed PFO-closure guided by TEE. Procedural and intrahospital survival was 100%. Survival after a mean follow-up of 17.1±1.6months was 100%. "Catheter in sheath” technique was adopted in 16 cases. After the procedure, all 28 migraines with aura alleviated at different degree. All 10 patients suffering from pre-operational cryptogenic stroke survived and showed no evidence for recurrence of stroke (fatal or non-fatal), peripheral embolism or transient ischemic attack during follow-up. No serious adverse events in the PFO closure procedure and during the follow-up period.Conclusion First clinical experiences showed that percutaneous TEE guided PFO closure is safe and effective and might be promoted.
Systolic Aortic Root Motion and Angle as novel indices of Left Ventricular Systolic Function
Authors: soltan ghada m , kersh ahmed m el , sami nevien e , yehia ghadeer m , soliman mahmoud ali 
Published: January 2020

Abstract
Background Aortic root motion was used only as a surrogate parameter of global left ventricular systolic function depending on its direct proportion to cardiac output. We hypothesize that aortic root motion angle and aortic root motion amplitude may overcome many limitations of EF calculation by M mode and two dimensional methods and are easier and reproducible.Objective The aim of this study is to asses systolic aortic root motion measured by M mode and aortic root motion angle as novel indices of global left ventricular systolic function.Patients and methods one hundred patients were enrolled in this study and divided into four groups: according to their age (above and below 60 years) and EF (above and below50%). They were subjected to full history taking, careful clinical examination, and conventional echo-Doppler study .Systolic aortic root motion obtained from long axis parasternal view by M-mode echo guided by 2D echo, and aortic root motion angle was traced off line and mathematically measured. Also global logitudinal strain (GLS) and global longitudinal strain rate (GLSR) from apical 4,3 and 2 chamber views were measured offline.Results Statistical analysis of collected data show that there are significant differences between control groups and patient groups in aortic root motion angle (t= 16.9 and p value <0.001, and in aortic root motion amplitude (t= 20.1 and p value <0.001). Aortic root motion (cm) and aortic root motion angle have significant positive correlation with EF(Mm), EF(2D), Fs, global longitudinal strain(GLS) and global Strain rate . The best cutoff value of aortic root motion angle was 19.5 degree, with sensitivity of 93.9%, specificity of 96.1.Aortic root motion angle >19.5 predicts systolic function >50% and that<19.5 predicts systolic function <50% The best cutoff value of aortic root SAM was 8.5 mm. An aortic root SAM of ˂ 8.5 mm predicts an LVEF of ˂ 50% with sensitivity of 95.9%, specificity of 96.1%.Conclusion The amplitude of systolic aortic root motion (SARM) by (M-mode) and aortic root motion angle are well- correlated with the EF and GLS and could be considered as novel indices of global left ventricular systolic function with high accuracy and reproducibility .
Long term crop rotation effect on soybean yield explained by soil- and root-associated microbiome and soil health indicators
Authors: Neupane Achal , Bulbul Izzet , Wang Ziyi , Lehman R. Michael , Nafziger Emerson , Marzano Shin-Yi Lee 
Published: January 2020

Abstract
Background Crop rotation is an important management tactic that farmers use to manage crop production and reduce pests and diseases. Long-term crop rotations may select groups of microbes that form beneficial or pathogenic associations with the following crops, which could explain observed crop yield differences with different crop sequences. To test this hypothesis, we used two locations each with three long-term (14 year), replicated, crop rotation treatments: continuous corn ( Zea mays ) (CCC), corn/corn/soybean (SCC), and corn/soybean (CSC); both CSC and SCC had each phase present each year. In Year 15, we grew soybean ( Glycine max ) in each plot, so that soybean replaced corn in CCC and in the CSC phase where soybean grew in Year 14, and took data from soybeans following CCC (14 years of corn), SCC (two years of corn), CSC (one year of corn), and SCS (one year of soybean). Soybean yield and soil health indicators were measured, along with the bulk soil microbiome and soybean root-associated microbiome.Results Soybean yields were significantly higher following CCC than in the other three treatments at both locations. Soil protein as a soil health indicator was also higher following CCC than in the other treatments. Differential abundances of bacterial and fungal taxa were related to yield differences in a site-specific manner. Uncultured bacterial taxa in family JG30-KF-AS9 was enriched in the high-yielding CCC plots in Monmouth, whereas Microvirga , Rhodomicrobium , and Micromonosporaceae were enriched in the low-yielding SCS plots. Members of the fungal phylum Ascomycota were informative in explaining yield differences among treatments mostly as pathogens, but Tumularia , Pyrenochaetopsis and Schizothecium were enriched in the CCC plots, suggesting a role as either corn pathogens or beneficial fungal taxa for soybean. Multivariate analysis associated soil health indicators with the rotation regimes and some of the differentially abundant microbial taxa.Conclusions Our finding of associations between soil health indicators related to soil microbial populations and soybean yield following different cropping sequences has wide-ranging implications, opening the possibility of both monitoring and manipulating soil microbial populations as a way to improve crop yield potential.
The long noncoding RNA-30162 is regulated by commensal microbiota and modulates CCL24 and ARG1 in macrophages
Authors: Mu Yingjie , Chen Wen , Hu Shilian , Cheng Min 
Published: January 2020

Abstract
Background Alveolar macrophages (AMs) are the largest number of innate immune cells in the distal lung. AMs have critical roles in maintaining immunological homoeostasis and host defense in the lung and are inherently suppressive. Immune homeostasis depends on the integrity of microbiome, which contribute to appropriate maturation and priming of the immune system. The absence of commensal microbiota can lead to changes in AM function; however, little is known about the effect of long non-coding RNA (lncRNA) molecules in this process. Results Here, by lncRNA microarray analysis using AM samples from antibiotic-treated (Abt) mice, we found that treatment with antibiotics resulted in differential expression of numerous lncRNAs in AMs. Target genes of differentially expressed lncRNAs were associated with several biological pathways, including regulation of immune system processes, angiogenesis, cell differentiation, and chemotaxis, among others. Notably, lncRNA-30162 expression levels were up-regulated in AMs from Abt mice. Moreover, knockdown of lncRNA-30162 expression significantly reduced CCL24 and ARG1 levels in macrophages. Conclusions These findings indicate that microbiome can regulate the expression of lncRNA-30162 in AMs, identifying a molecular mechanism underlying lncRNA-mediated regulation of macrophage functions.