bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic and Prognostic Nomograms for Bone Metastasis in Patients With Newly Diagnosed Renal Cell Carcinoma
Authors: Huang Zhangheng , Hu Chuan , Tong Yuexin , Zhao Chengliang 
Published: September 2020

Abstract
BackgroundBone metastasis (BM) is one of the common sites of renal cell carcinoma (RCC), and patients with BM have a worse prognosis than those without it. We aimed to develop two nomograms to quantify the risk of BM and predict the prognosis of RCC patients with BM.MethodsWe reviewed patients with newly diagnosed RCC with BM in the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2015. Multivariate logistic regression analysis was used to determine independent predictors of BM in RCC patients. Univariate and multivariate Cox proportional hazards regression analysis was used to determine independent prognostic factors for BM in RCC patients. Diagnostic and prognostic nomograms were established and evaluated by calibration curve, receiver operating characteristic (ROC) curve, and decision curve analysis (DCA).ResultsThe study included 37554 patients newly diagnosed with RCC in the SEER database, 537 of whom were BM patients. Risk factors for BM in RCC patients included sex, tumor size, liver metastasis, lung metastasis, brain metastasis, N stage, T stage, histologic type, and grade. Independent prognostic factors for RCC with BM were grade, histologic type, N stage, surgery, brain metastasis, and lung metastasis. Calibration, ROC curve, and DCA showed that both diagnostic and prognostic nomograms showed good performance.ConclusionsDiagnostic and prognostic nomograms were established to predict the risk of BM in RCC and the prognosis of RCC with BM, respectively. These nomograms strengthen each patient's prognosis-based decision making, which is of great significance in improving the prognosis of patients.
Bioinformatic Characteristics and Therapeutic Mechanisms of Calycosin-Anti-Bisphenol A-related Osteosarcoma
Authors: Tan Jiachang , Wu Zhenjie , Chen Jun , Mo Hao , Liu Bin , Yuan Zhenchao 
Published: September 2020

Abstract
BackgroundEnvironmentally, bisphenol A (BPA) is well-known as a pollutant caused human health risk, such as osteosarcoma (OS). OS, a deadly bone neoplasia, may occur in children and adults. Recently, the anti-OS pharmacotherapy prescribes limitedly. Interestingly, our previous experiments evidence that calycosin exerts the potential anti-OS action in vitro. Thus, in this report, we aimed to characterize and detail the therapeutic targets and mechanisms of calycosin-anti-BPA-related OS by means of network pharmacology and molecular docking analyses. ResultsIn details, the bioinformatic data revealed the mapped, core targets, biological functions, molecular pathways of calycosin to treat BPA-related OS. The computational analysis indicated that molecular docking ability and characteristic of core targets in calycosin to treat BPA-related OS were identified. Meanwhile, all optimal functions and pathways of calycosin-anti-BPA-related OS were revealed, as detailed in pathway networks. ConclusionsTaken together, the network pharmacology and structural biology findings illustrate the core biotargets, pharmacological functions and pathways of calycosin-anti-BPA-related OS. Potentially, these identified core targets may attribute to the scientific development of calycosin against BPA-related OS.
Correlation Between COVID-19 Severity, Body Mass Index and Hepatic Steatosis: A Retrograde Cohort Study
Authors: Qandeel Haitham , Tayyem Raed , Fataftah Jehad , Qasem Muhannad , Sami Rawan , Ashour Haneen , Hasanat Subreen , Tayyem Rand , Alqassieh Rami 
Published: September 2020

Abstract
Background Obesity and fatty liver steatosis are already considered metabolic risk factors that may aggravate the severity of COVID-19. This study aims to investigate the correlation between COVID-19 severity, body mass index, and hepatic steatosis. MethodsConsecutive patients with laboratory-confirmed COVID-19, admitted to a hospital devoted to COVID-19 patients, were enrolled in the study. COVID-19 severity was classified as severe versus non-severe based on the condition at time of admission to ICU. Obesity was assessed by Body Mass Index (BMI). CT-scan of the patient liver was used to check for the hepatic steatosis. Fibrosis-4 score was calculated.Results230 patients were enrolled in this study. Obesity strongly and positively correlated with severe COVID-19 illness. Hepatic steatosis had rather less of a correlation with COVID-19 severity. Multivariable-adjusted association between hepatic steatosis or obesity, or both (as exposure) and COVID-19 severity (as the outcome) revealed an increased risk of severe COVID-19 illness with obesity, with hepatic steatosis, and with hepatic steatosis among obese patients. ConclusionsBMI remained the most noticeable factor that strongly correlated with COVID-19 severity. Obesity even in the absence of hepatic steatosis greatly increased the risk of severe COVID-19. This association remained significant after adjusting for likely confounders. The presence of liver steatosis even in non-obese patients increased the risk of severe COVID-19 but to a much lesser degree compared to obesity. The risk of steatosis to COVID-19 severity was greater in those with than those without obesity. This association also remained significant after adjusting for likely confounders
Development and Validation of the Cognitive Behavioral Therapy Skills Scale Among Japanese College Students
Authors: Sakata Masatsugu , Toyomoto Rie , Yoshida Kazufumi , Luo Yan , Nakagami Yukako , Aoki Shuntaro , Irie Tomonari , Sakano Yuji , Suga Hidemichi , Sumi Michihisa , Muto Takashi , Shiraishi Nao , Sahker Ethan , Uwatoko Teruhisa , Furukawa Toshi A. 
Published: September 2020

Abstract
Background: There are many different skill components used in cognitive-behavioral therapy (CBT). However, there is currently no comprehensive way of measuring these skills in patients. Assessing pretreatment CBT skills will contribute to prediction of treatment responses in the context of CBT for depression.Methods: We developed the CBT Skills Scale from five pre-existing instruments measuring major CBT components: self-monitoring, behavioral activation, cognitive restructuring, assertiveness training, and problem-solving. University students (N = 847) who participated in a fully factorial randomized controlled trial of smartphone CBT were assessed with the CBT Skills Scale, the Patient Health Questionnaire-9 (PHQ-9), the Generalized Anxiety Disorder 7 (GAD-7), and the short form of the Japanese Big Five Scale. Structural validity was estimated with exploratory factor analysis (EFA) and confirmatory factor analysis (CFA), and internal consistency evaluated with Cronbach’s α coefficients. Construct validity was evaluated with the correlations between each factor of the CBT Skills Scale, the PHQ-9, the GAD-7, and the Big Five Scale.Results: The EFA supported a five-factor solution based on the original instruments assessing each CBT skill component. The CFA showed sufficient goodness-of-fit indices for the five-factor structure. The Cronbach’s α of each factor was 0.75-0.81. Each CBT skills factor was specifically correlated to the PHQ-9, GAD-7, and the Big Five Scale.Conclusions: The CBT Skills Scale has a stable structural validity and internal consistency with a five-factor solution and appropriate content validity concerning the relationship with depression, anxiety, and personality. Trial registration: UMIN, CTR-000031307. Retrospectively registered on February 14, 2018.
Developing a Short-Form Version of the HIV Disability Questionnaire (SF-HDQ) for Use in Clinical Practice:&nbsp;A Rasch Analysis
Authors: O'Brien Kelly K , Dzingina Mendwas , Harding Richard , Gao Wei , Namisango Eve , Avery Lisa , Davis Aileen M 
Published: September 2020

Abstract
Background: Disability is an increasingly important health-related outcome to consider as more individuals are now aging with HIV and multimorbidity. The HIV Disability Questionnaire (HDQ) is a patient-reported outcome measure (PROM), developed to measure the presence, severity and episodic nature of disability among adults living with HIV. The 69-item HDQ includes six domains: physical, cognitive, mental-emotional symptoms and impairments, uncertainty and worrying about the future, difficulties with day-to-day activities, and challenges to social inclusion. Our aim was to develop a Short-Form version of the HIV Disability Questionnaire (SF-HDQ) to facilitate use in clinical and community-based practice among adults living with HIV.Methods: We used Rasch analysis to inform item reduction using an existing dataset of adults living with HIV in Canada (n=941) and Ireland (n=96) who completed the HDQ (n=1037). We evaluated overall model fit with Cronbach’s alpha and Person Separation Indices (PSIs) (≥ 0.70 acceptable). Individual items were evaluated for item threshold ordering, fit residuals, differential item functioning (DIF) and unidimensionality. For item threshold ordering, we examined item characteristic curves and threshold maps merging response options of items with disordered thresholds to obtain order. Items with fit residuals >2.5 or less than -2.5 and statistically significant after Bonferroni-adjustment were considered for removal. For DIF, we considered removing items with response patterns that varied according to country, age group (≥50 years versus <50 years), and gender. Subscales were considered unidimensional if ≤5% of t-tests comparing possible patterns in residuals were significant. Results: We removed 34 items, resulting in a 35-item SF-HDQ with domain structure: physical (10 items); cognitive (3 items); mental-emotional (5 items); uncertainty (5 items); difficulties with day-to-day activities (5 items) and challenges to social inclusion (7 items). Overall models’ fit: Cronbach’s alphas ranged from 0.78 (cognitive) to 0.85 (physical and mental-emotional) and PSIs from 0.69 (day-to-day activities) to 0.79 (physical and mental-emotional). Three items were rescored to achieve ordered thresholds. All domains demonstrated unidimensionality. Three items with DIF were retained because of their clinical importance.Conclusion: The 35-item SF-HDQ offers a brief, comprehensive disability PROM for use in clinical and community-based practice with adults living with HIV.
Vietnamese people’s well-being during the COVID-19 pandemic: an online survey&nbsp;
Authors: Hoang Tuyen Dinh , Colebunders Robert , Fodjo Joseph Nelson Siewe , Nguyen Nhan Phuc Thanh , Tran Trung Dinh , Vo Thang Van 
Published: September 2020

Abstract
Background: The COVID-19 pandemic, alongside the restrictive measures implemented for its control, may considerably affect people’s lives particularly vulnerable persons such as children, elderly and people with underlying diseases. This study aimed to assess the well-being of Vietnamese people after COVID-19 lockdown measures were lifted and life gradually returned to normal in Vietnam.Methods: An online survey was organized from 21st to 25th April 2020 among Vietnamese residents aged 18 and over. Data were collected concerning the participants’ health status, COVID-19 preventive behaviour, and consequences of the preventive measures. The WHO-5 Well-Being Index was used to score participants’ well-being.Results: A total of 1922 responses were analyzed (mean age was 31 years; range: 18-76). Factors associated with a high well-being score included older age, eating healthy food, practising physical exercise, working from home, and adherence to the COVID-19 preventive measures. Female participants, persons worried about their relatives’ health, and smokers were more likely to have a low well-being score.Conclusions: The Vietnamese people continued to follow COVID-19 preventive measures even after the lockdown was lifted. Most respondents scored high on the well-being scale. However, the emergence of a new COVID-19 outbreak with an epicenter in Da Nang city is expected to increase public anxiety and mental health problems. It is clear that together with preventive measures, developing strategies to guarantee the well-being of the Vietnamese people’s is equally important.
An Analysis of the Services Provided by Municipal Ward Based Primary Health Care Outreach Teams in an Urban District in South Africa: A Key Contribution Towards Universal Access to Care.
Authors: Thomas Leena Susan , Buch Eric , Pillay Yogan 
Published: September 2020

Abstract
Introduction: Municipal Ward based PHC Outreach Teams are potential game-changers in ensuring access to care in vulnerable communities. Who are they? What do they actually do? Can they help South Africa realize universal health coverage?Methods:Descriptive secondary data analysis of team activities in the Ekurhuleni health district, South Africa covering approximately 280 000 households with one million people. This was part of a larger study exploring the effectiveness of these teams.Results:Study findings illustrated that CHWs in these teams provided early screening and referrals for pregnant women and malnourished children. They distributed condoms and chronic medication to homes. They screened and referred for hypertension, diabetes mellitus, HIV and TB. The teams also undertook defaulter and contact tracing, the majority of which was for HIV & TB clients. Psychosocial support provided was in the form of access to social grants, access to child and gender based violence protection services, food parcels and other services.Conclusion:Community Health Workers form the core of these teams and perform several health and psychosocial services in households and to poor communities in South Africa, in addition to general health education. The teams studied provided a range of activities across many health conditions (mother & child related, HIV & TB, non-communicable diseases), as well as social services. Ward based outreach teams provided comprehensive care in a large-scale urban setting and can improve access to care.
Effect of marketable ages on meat quality through fiber characteristics in goose
Authors: Weng Kaiqi , Huo Weiran , Gu Tiantian , Bao Qiang , Hou Li-e , Zhang Yu , Zhang Yang , Xu Qi , Chen Guohong 
Published: September 2020

Abstract
Background: Goose meat is more and more popular among consumers because of its good quality. The fiber characteristics, as a key determinant factor, contributing to meat quality has been well demonstrated, and the marketable ages are also closely related to meat quality in livestock and chicken. However, little is known about the effect of different marketable ages on the meat quality through fiber characteristics in goose. Results: Here, 1-day, 28-day and three market-age old (70, 90 & 120 days) Yangzhou geese were selected and their fiber characteristics were investigated. The results showed that only fast-twitch fibers were observed in the breast muscle irrespective of the ages, while little slow-twitch fibers could be identified in leg muscle in three marketable ages, especially in gastrocnemius and extensor digitorum longus. As for the fiber diameter, a rapid upward trend was observed in breast muscle from 70 days to 90 days, and the corresponding values were 19.88 to 26.27μm, respectively, and it remained stable 90d thereafter. While the diameter and cross-sectional area of muscle fiber in leg muscle increased with ages. In addition, the proximate composition and physical properties was measured at different ages. 120-day-old geese had richer intramuscular fat and protein content both in breast and leg meat, as well as lower moisture content among three marketable ages. The higher lightness and pressing loss and the lower redness and shear force was observed in the breast and leg meat of 70-day-old geese compared with the 90 and 120-day-old geese. Conclusions: Taken together, although longer marketable age did not affect muscle fiber type in geese, it resulted in a thicker muscle fiber area, richer intramuscular fat and protein content, redder and chewier meat. As a result, the reasonable marketable age should be taken into account to improve the meat quality in the goose production.
Evaluation of the Online Virtual Reality 360° World Cultural Heritage Tourism under the Charter on Interpretation and Presentation of Cultural Heritage during the Covid-2019 Outbreak
Authors: Ren Wei , Chen Xianhong 
Published: September 2020

Abstract
This study has formulated an evaluation framework for the interpretation and presentation performance of Online virtual reality 360°world cultural heritage tourism (OVRWCHT) approach during the covid-2019 break. The research framework is based on seven main principles of the Charter of the World Cultural Heritage Interpretation and Presentation theory, and establishes evaluation criteria for each principle. The World Cultural Heritage Site Hailongtun Tusi was selected as the case study, the Online virtual reality 360° system was for this site was established and evaluated accordingly. A collection of 1062 effective online questionnaires were support the evaluation. The results show that the OVRWCHT made by the research team which has received relatively wide recognition from stakeholders during the COVID-2019 outbreak period. However, it still needs more data support to improve technology and theory, especially transferability of OVRWCHT in other countries besides China. Finally, this study suggests that the ICOMOS should continue to issue relevant charters (documents) on how emerging technologies which may activate cultural heritage interpretation and presentation.
The Comparison of Water Intake Patterns and Hydration Biomarkers among Young Adults with Different Hydration Statuses in Hebei, China
Authors: Zhang Jianfen , Zhang Na , Liu Shufang , Du Songming , He Hairong , Ma Guansheng 
Published: September 2020

Abstract
Background: Water is essential for maintaining the functions of human body properly. Studies have shown that the amounts and contributions of fluids were associated with health and hydration status. The objectives of the study was that to explore the differences of water intake pattern and hydration biomarkers among young males and females in different hydration statuses.Methods: A cross-sectional study was implemented among 159 young adults aged 18-23 years in Hebei, China. The total drinking fluids and water from food were obtained by 7-day 24-h fluid intake questionnaire and duplicate portion method, respectively. The osmolality and electrolyte concentrations of the 24h urine and plasma were tested. Differences in optimal hydration (OH), middle hydration (MH) and hypohydration (HH) groups, divided by the osmolality of 24h urine, were compared. Results: Totally, 156 participants (80 males and 76 females) completed the study. OH group had highest proportions of participants met the recommendations of TWI (total water intake) and total drinking fluids of China (34.5%, 36.2%), while HH group had lowest (7.7%, 0.0%). OH group had higher amounts of TWI, total drinking fluids, water and lower amounts of SSBs (sugar-sweetened-beverages) (p<0.05). The percentage of total drinking fluids in TWI decreased from 54.1% in OH group to 42.6% in HH group (p<0.05). OH group had higher and lower contributions of water and SSBs (sugar-sweetened-beverages) to total drinking fluids (p<0.05); produced 551~950 mL more, excreted significantly less quantity of solutes of urine (p<0.05). No significant differences were found in plasma osmolality among the three groups (p>0.05). Among both males and females, the amounts of TWI and water were higher in OH group than others (p<0.05). Males had 4.3% lower, 5.4% and 1.1% higher contributions of milk and milk products, SSBs and alcohol to total drinking fluids than females (p<0.05); males had higher volume of urine than females only in MH group (p<0.05). There were no significant differences of plasma osmolality between males and females in the same group (p>0.05). Conclusions: Young adults with optimal hydration status had better water intake pattern and less concentrated urine. Females maybe have better water intake pattern than males.Trial registration: Chinese clinical trial registry. Name of the registry: Relationship of drinking water and urination. Trial registration number: ChiCTR-ROC-17010320. Date of registration: 01/04/2017. URL of trial registry record: http://www.chictr.org.cn/edit.aspx?pid=17601&htm=4.
Estimation of vector competence of Moroccan Sand fly Populations Using a Proteomic Approach
Authors: Daoudi Mohamed , Dong George , Boussaa Samia , Martel Caroline , Hafidi Mohamed , Boumezzough Ali , Olivier Martin 
Published: September 2020

Abstract
Background Phlebotomine vector born disease are distributed throughout the world, and different pathogens are associated with varying degrees of disease severity. In Morocco, sand fly populations are incriminated in the transmission of several pathogens, such Leishmania spp. and phlebovirus, in particular the most relevant sand fly species as the case of Phlebotomus papatasi. This species is the main vector of Leishmania major in Morocco, and incriminated in phlebovirus transmission. Not to pass over without investigating its possible role on the transmission of entomopathogenic parasite already reported in literature. Methodology and finding The present study focused on proteomic analysis in Phlebotomus papatasi from four localities in Morocco. Proteomic analysis in female P. papatasi was performed with Liquid chromatography-tandem mass spectrometry (LC-MS/MS). A total of 239 identified proteins for Leishmania spp., 26 identified proteins for phlebovirus and 1132 identified proteins for nematode were detected in the 20 pools of P. papatasi from investigated localities. The microscopic examination of 1752 sandflies collected showed, the infection of two specimens of female’s P. sergenti with Tetranematid Didilia spp. and potential Microfilariae in Imintanout locality (Z2).Conclusion This study presents the first report of nematodes in sand flies of Africa. Also, the first use of proteomic tools for estimation of vector competence of P. papatasi which could be a specific tool to a better understanding of the vectorial capacity of Moroccan sandflies population.
Oval Forceps Assisted with Small Incision for Minimally Invasive Treatment of Acute Achilles Tendon Rupture
Authors: Zhao Yan-Rui , Liu Yang , Yin Bo , Li Yihan , Guo Meng , Zhou Junlin 
Published: September 2020

Abstract
Purpose: To review the clinical outcomes of treatment acute Achilles tendon rupture using oval forceps assisted with small incision.Methods: This was a retrospective study of 23 patients with acute Achilles tendon rupture treated with this technique. Distance from calcaneal insertion to rupture site and the operation time were recorded. During follow-up, all the occurrence of complications was recorded. The AOFAS score and the ROM of the repaired ankle joint were recorded at 3 and 6 months.Results: All patients were followed up for 7-15 months. There have no cases of Achilles tendon re-rupture and sural nerve injury were found. All incisions healed by first intention, except for one case of delayed suture knot irritation. The AOFAS score was 82–100 (median, 92) at 3 months and 92–100 (median, 98) at 6 months. The 3-month ROM was 28–37, and the 6-month ROM was 36–49.Conclusion: The technique of oval forceps assisted with small incision for minimally invasive treatment of acute Achilles tendon rupture is a safe, reliable, and have an extremely low complication rate. Furthermore, this technique is easy to learn, utilizes simple instruments, and is cost-effective, making this technique an attractive alternative to traditional techniques.