bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Benefit of Advanced Inflammatory Bowel Disease Training: Challenges and Solutions
Authors: Cushing Kelly C , Adar Tomer , Ciorba Matthew , Ananthakrishnan Ashwin N 
Published: March 2020

AbstractBackgroundAdvanced inflammatory bowel disease (IBD) fellowships are available for gastroenterologists who wish to increase their expertise in complex IBD. However, little is known about the outcomes of such training. The aims of this study were to assess clinical and academic outcomes following advanced training in IBD.MethodsWe surveyed gastroenterologists who completed advanced IBD fellowships and compared competency and outcomes to gastroenterologists focusing in IBD who completed gastroenterology training alone. Participants completed a survey via REDCap. Continuous variables were compared using the Wilcoxon rank-sum test. Categorical variables were compared using chi-square or Fisher’s exact tests.ResultsA total of 104 physicians participated in the study. IBD fellowships were completed by 31 physicians (30%), of whom 29 (94%) felt their training was excellent. Management of complicated IBD (84%), research mentoring (74%), and career mentoring (71%) were felt to contribute most highly to professional development. Compared to non-advanced trained physicians, advanced trained physicians expressed higher levels of comfort with management of IBD during pregnancy (P = 0.003), complicated IBD (P = 0.057), and peri-operative IBD (P = 0.057). No significant advantage was detected in academic productivity. Common barriers to participation in IBD fellowships included feeling it was unnecessary (45%) and desire to begin a faculty position (42%).ConclusionsThis study suggests there may be clinical benefit to advanced IBD training. Importantly, this study identified that there are also unique challenges to the assessment of clinical competency in IBD training. Efforts by the IBD community to establish a registry of advanced trainees and improve competency assessments are needed.
Reversing the Tide: Improving the Recruitment of Patients With Inflammatory Bowel Disease in Clinical Trials in the United States
Authors: Deepak Parakkal 
Published: March 2020

AbstractWhile the number of inflammatory bowel disease (IBD) clinical trials has been increasing, there is decreasing participation in these trials with under-representation of younger patients and those with milder disease and in community settings. Innovative methods to increase recruitment and participation through the use of social media tools, apps, electronic medical record-based patient finding algorithms, and remote monitoring methods are suggested.
Composite damage zones in the subsurface
Authors: Liao Zonghu , Li Wei , Zou Huayao , Hao Fang , Marfurt Kurt J , Reches Ze'ev 
Published: March 2020

SUMMARYThe cumulative displacement by multiple slip events along faults may generate composite damage zones (CDZ) of increasing width, and could modify the hydraulic and mechanical properties of the faults. The internal architecture and fracture distribution within CDZs at the subsurface are analysed here by using seismic attributes of variance, curvature and dip-azimuth of the 3-D seismic reflection data from tight sandstone reservoirs in northeast Sichuan, China. The analysed faults intersect the reservoir within a depth range of 2.4–3.0 km. The damage intensity mapping revealed multiple CDZs with thicknesses approaching 1 km along faults ranging 3–15 km in length, and up to 1000 m of cumulative slip. The identification of numerous fault cores and associate damage zones led us to define three classes of CDZs: banded shape, box shape and dome shape. The mechanical strength contrasts and distortion of fault cores suggest potential weakening and strengthening (healing) mechanisms for formation of CDZs that can be extended to faulting processes and earthquake simulations.
One-dimensional deep learning inversion of electromagnetic induction data using convolutional neural network
Authors: Moghadas Davood 
Published: March 2020

SUMMARY
Conventional geophysical inversion techniques suffer from several limitations including computational cost, nonlinearity, non-uniqueness and dimensionality of the inverse problem. Successful inversion of geophysical data has been a major challenge for decades. Here, a novel approach based on deep learning (DL) inversion via convolutional neural network (CNN) is proposed to instantaneously estimate subsurface electrical conductivity (σ) layering from electromagnetic induction (EMI) data. In this respect, a fully convolutional network was trained on a large synthetic data set generated based on 1-D EMI forward model. The accuracy of the proposed approach was examined using several synthetic scenarios. Moreover, the trained network was used to find subsurface electromagnetic conductivity images (EMCIs) from EMI data measured along two transects from Chicken Creek catchment (Brandenburg, Germany). Dipole–dipole electrical resistivity tomography data were measured as well to obtain reference subsurface σ distributions down to a 6 m depth. The inversely estimated models were juxtaposed and compared with their counterparts obtained from a spatially constrained deterministic algorithm as a standard code. Theoretical simulations demonstrated a well performance of the algorithm even in the presence of noise in data. Moreover, application of the DL inversion for subsurface imaging from Chicken Creek catchment manifested the accuracy and robustness of the proposed approach for EMI inversion. This approach returns subsurface σ distribution directly from EMI data in a single step without any iterations. The proposed strategy simplifies considerably EMI inversion and allows for rapid and accurate estimation of subsurface EMCI from multiconfiguration EMI data.
Vertical Transmission of Gut Microbiome and Antimicrobial Resistance Genes in Infants Exposed to Antibiotics at Birth
Authors: Li Weizhong , Tapiainen Terhi , Brinkac Lauren , Lorenzi Hernan A , Moncera Kelvin , Tejesvi Mysore V , Salo Jarmo , Nelson Karen E 
Published: March 2020

Abstract
Vertical transmission of maternal microbes is a major route for establishing the gut microbiome in newborns. The impact of perinatal antibiotics on vertical transmission of microbes and antimicrobial resistance is not well understood. Using a metagenomic approach, we analyzed the fecal samples from mothers and vaginally delivered infants from a control group (10 pairs) and a treatment group (10 pairs) receiving perinatal antibiotics. Antibiotic-usage had a significant impact on the main source of inoculum in the gut microbiome of newborns. The control group had significantly more species transmitted from mothers to infants (P = .03) than the antibiotic-treated group. Approximately 72% of the gut microbial population of infants at 3–7 days after birth in the control group was transmitted from their mothers, versus only 25% in the antibiotic-treated group. In conclusion, perinatal antibiotics markedly disturbed vertical transmission and changed the source of gut colonization towards horizontal transfer from the environment to the infants.
Variation in the Relative Isomer Abundance of Synthetic and Biologically Derived Phosphatidylethanols and Its Consequences for Reliable Quantification
Authors: Luginbühl Marc , Young Reuben S E , Stoeth Frederike , Weinmann Wolfgang , Blanksby Stephen J , Gaugler Stefan 
Published: March 2020

Abstract
Phosphatidylethanol (PEth) in human blood samples is a marker for alcohol usage. Typically, PEth is detected by reversed-phase liquid chromatography coupled with negative ion tandem mass spectrometry, investigating the fatty acyl anions released from the precursor ion upon collision-induced dissociation (CID). It has been established that in other classes of asymmetric glycerophospholipids, the unimolecular fragmentation upon CID is biased depending on the relative position (known as sn-position) of each fatty acyl chain on the glycerol backbone. As such, the use of product ions in selected-reaction-monitoring (SRM) transitions could be prone to variability if more than one regioisomer is present in either the reference materials or the sample. Here, we have investigated the regioisomeric purity of three reference materials supplied by different vendors, labeled as PEth 16:0/18:1. Using CID coupled with ozone-induced dissociation, the regioisomeric purity (% 16:0 at sn-1) was determined to be 76, 80 and 99%. The parallel investigation of the negative ion CID mass spectra of standards revealed differences in product ion ratios for both fatty acyl chain product ions and ketene neutral loss product ions. Furthermore, investigation of the product ion abundances in CID spectra of PEth within authentic blood samples appears to indicate a limited natural variation in isomer populations between samples, with the cannonical, PEth 16:0/18:1 (16:0 at sn-1) predominant in all cases. Different reference material isomer distributions led to variation in fully automated quantification of PEth in 56 authentic dried blood spot (DBS) samples when a single quantifier ion was used. Our results suggest caution in ensuring that the regioisomeric compositions of reference materials are well-matched with those of the authentic blood samples.
Health Insurance Coverage Disruptions and Cancer Care and Outcomes: Systematic Review of Published Research
Authors: Yabroff K Robin , Reeder-Hayes Katherine , Zhao Jingxuan , Halpern Michael T , Lopez Ana Maria , Bernal-Mizrachi Leon , Collier Anderson B , Neuner Joan , Phillips Jonathan , Blackstock William , Patel Manali 
Published: March 2020

Abstract

Background
Lack of health insurance coverage is associated with poor access and receipt of cancer care and survival in the United States. Disruptions in coverage are common among low-income populations, but little is known about associations of disruptions with cancer care, including prevention, screening, and treatment, as well as outcomes of stage at diagnosis and survival.

Methods
We conducted a systematic review of studies of health insurance coverage disruptions and cancer care and outcomes published between 1980 and 2019. We used the PubMed, EMBASE, Scopus, and CINAHL databases and identified 29 observational studies. Study characteristics and key findings were abstracted and synthesized qualitatively.

Results
Studies evaluated associations between coverage disruptions and prevention or screening (31.0%), treatment (13.8%), end-of-life care (10.3%), stage at diagnosis (44.8%), and survival (20.7%). Coverage disruptions ranged from 4.3% to 32.8% of patients age-eligible for breast, cervical, or colorectal cancer screening. Between 22.1% and 59.5% of patients with Medicaid gained coverage only at or after cancer diagnosis. Coverage disruptions were consistently statistically significantly associated with lower receipt of prevention, screening, and treatment. Among patients with cancer, those with Medicaid disruptions were statistically significantly more likely to have advanced stage (odds ratios = 1.2-3.8) and worse survival (hazard ratios = 1.28-2.43) than patients without disruptions.

Conclusions
Health insurance coverage disruptions are common and adversely associated with receipt of cancer care and survival. Improved data infrastructure and quasi-experimental study designs will be important for evaluating the associations of federal and state policies on coverage disruptions and care and outcomes.
Deriving stellar parameters from GALANTE photometry: bias and precision
Authors: Lorenzo-Gutiérrez A , Alfaro E J , Maíz Apellániz J , Barbá R H , Marín-Franch A , Ederoclite A , Cristóbal-Hornillos D , Varela J , Vázquez Ramió H , Cenarro A J , Lennon D J , García-Lario P , Daflon S , Borges Fernandes M 
Published: March 2020

ABSTRACT
In this paper, we analyse how to extract the physical properties from the GALANTE photometry of a stellar sample. We propose a direct comparison between the observational colours (photometric bands normalized to the 515 nm central wavelength) and the synthetic colours derived from different stellar libraries. We use the reduced χ2 as the figure of merit for selecting the best fitting between both colour sets. The synthetic colours of the Next Generation Spectral Library (NGSL) provide a valuable sample for testing the uncertainty and precision of the stellar parameters derived from observational data. Reddening, as an extrinsic stellar physical parameter becomes a crucial variable for accounting for the errors and bias in the derived estimates: the higher the reddenings, the larger the errors and uncertainties in the derived parameters. NGSL colours also enable us to compare different theoretical stellar libraries for the same set of physical parameters, where we see how different catalogues of models can provide very different solutions in a, sometimes, non-linear way. This peculiar behaviour makes us to be cautious with the derived physical parameters obtained from GALANTE photometry without previous detailed knowledge of the theoretical libraries used to this end. In addition, we carry out the experiment of deriving physical stellar parameters from some theoretical libraries, using some other libraries as observational data. In particular, we use the Kurucz and Coelho libraries, as input observational data, to derive stellar parameters from Coelho + TLUSTY and Kurucz + TLUSTY stellar libraries, respectively, for different photometric errors and colour excesses.
Robust sulfonated poly (ether ether ketone) nanochannels for high-performance osmotic energy conversion
Authors: Zhao Yuanyuan , Wang Jin , Kong Xiang-Yu , Xin Weiwen , Zhou Teng , Qian Yongchao , Yang Linsen , Pang Jinhui , Jiang Lei , Wen Liping 
Published: March 2020

Abstract
The membrane-based reverse electrodialysis (RED) technique has a fundamental role in harvesting clean and sustainable osmotic energy existing in the salinity gradient. However, the current designs of membranes cannot cope with the high output power density and robustness. Here, we construct a sulfonated poly (ether ether ketone) (SPEEK) nanochannel membrane with numerous nanochannels for a membrane-based osmotic power generator. The parallel nanochannels with high space charges show excellent cation-selectivity, which could further be improved by adjusting the length and charge density of nanochannels. Based on numerical simulation, the system with space charge shows better conductivity and selectivity than those of a surface-charged nanochannel. The output power density of our proposed membrane-based device reaches up to 5.8 W/m2 by mixing artificial seawater and river water. Additionally, the SPEEK membranes exhibit good mechanical properties, endowing the possibility of creating a high-endurance scale-up membrane-based generator system. We believe that this work provides useful insights into material design and fluid transport for the power generator in osmotic energy conversion.
A systematic review of the influences of food store product placement on dietary-related outcomes
Authors: Shaw Sarah C , Ntani Georgia , Baird Janis , Vogel Christina A 
Published: March 2020

Abstract

Context
Product placement strategies have been used to influence customers’ food purchases in food stores for some time; however, assessment of the evidence that these techniques can limit unhealthy, and promote healthy, food choices has not been completed.

Objective
This systematic review aimed to determine how product placement strategies, availability, and positioning, in physical retail food stores located in high-income countries, influence dietary-related behaviors.

Data Sources
From a search of 9 databases, 38 articles, 17 observational studies, and 22 intervention studies met the study inclusion criteria.

Data Extraction
Two reviewers independently extracted data relating to study design, study population, exposures, outcomes, and key results. Each study was also assessed for risk of bias in relation to the research question.

Data Analysis
Meta-analysis was not possible owing to heterogeneous study designs and outcomes. As recommended by Cochrane, results were synthesized in effect direction plots using a vote-counting technique which recorded the direction of effect and significance level according to the expected relationship for health improvement.

Conclusions
The majority of studies showed that greater availability and more prominent positioning of healthy foods, or reduced availability and less prominent positioning of unhealthy foods, related to better dietary-related behaviors. A large number of results, however, were nonsignificant, which likely reflects the methodological difficulties inherent in this research field. Adequately powered intervention studies that test both the independent and additive effects of availability and positioning strategies are needed.

Systematic Review Registration
PROSPERO registration no. 42016048826
Preclinical cardiac organ damage during statin treatment in patients with inflammatory joint diseases: the RORA-AS statin intervention study
Authors: Os Hanna A , Rollefstad Silvia , Gerdts Eva , Kringeland Ester , Ikdahl Eirik , Semb Anne Grete , Midtbø Helga 
Published: March 2020

Abstract

Objective
Statin treatment has been associated with reduction in blood pressure and arterial stiffness in patients with inflammatory joint diseases (IJD). We tested whether statin treatment also was associated with regression of preclinical cardiac organ damage in IJD patients.

Methods
Echocardiography was performed in 84 IJD patients (52 RA, 20 ankylosing spondylitis, 12 psoriatric arthritis, mean age 61 (9) years, 63% women) without known cardiovascular disease before and after 18 months of rosuvastatin treatment. Preclinical cardiac organ damage was identified by echocardiography as presence of left ventricular (LV) hypertrophy, LV concentric geometry, increased LV chamber size and/or dilated left atrium.

Results
At baseline, hypertension was present in 63%, and 36% used biologic DMARDs (bDMARDs). Preclinical cardiac organ damage was not influenced by rosuvastatin treatment (44% at baseline vs 50% at follow-up, P = 0.42). In uni- and multivariable logistic regression analyses, risk of preclinical cardiac organ damage at follow-up was increased by higher baseline body mass index [odds ratio (OR) 1.3, 95% CI: 1.1, 1.5, P = 0.01] and presence of preclinical cardiac organ damage at baseline (OR 6.4, 95% CI: 2.2, 18.5, P = 0.001) and reduced by use of bDMARDs at follow-up (OR 0.3, 95% CI: 0.1, 0.9, P = 0.03).

Conclusion
Rosuvastatin treatment was not associated with a reduction in preclinical cardiac organ damage in IJD patients after 18 months of treatment. However, use of bDMARDS at follow-up was associated with lower risk of preclinical cardiac organ damage at study end, pointing to a possible protective cardiac effect of bDMARDs in IJD patients.

ClinicalTrials.gov
https://clinicaltrials.gov/NCT01389388
Systematic review and phylogeny of the firefly genus Dilychnia (Lampyridae: Lampyrinae), with notes on geographical range
Authors: Vaz Stephanie , Mermudes José Ricardo M , Paiva Paulo C , Da Silveira Luiz Felipe L 
Published: March 2020

Abstract
Dilychnia (Lampyridae: Lampyrinae) is a poorly known Neotropical genus of lampyrid firefly. Descriptions of Dilychnia species were traditionally based on differences in colour pattern, which are usually not reliable for species discrimination. Here, we review and redescribe the genus Dilychnia and its species, after examining the type material of all species, and we present the first phylogenetic analysis for the group, including 70 morphological characters and 15 species. After the proposal of new taxonomic combinations, Dilychnia was recovered as monophyletic with high support. We provide a key to species identification, updated geographical ranges and illustrations of diagnostic features for all species. We transfer Lucidota propinqua and Photinus succensus to Dilychnia and describe the new species Dilychnia dumasi sp. nov. We report, for the first time, that these three taxa are nocturnal and flash with an orange-yellow light. Phenotypic diversity within the genus is most pronounced in characters involved in mate tracking (i.e. antennae, eyes and light organs).
The Novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Directly Decimates Human Spleens and Lymph Nodes
Authors: Feng Zeqing , Diao Bo , Wang Rongshuai , Wang Gang , Wang Chenhui , Tan Yingjun , Liu Liang , Wang Changsong , Liu Ying , Liu Yueping , Yuan Zilin , Ren Liang , Wu Yuzhang , Chen Yongwen 
Published: March 2020

AbstractWhile lymphocytopenia is a common characteristic of patients infected by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the mechanisms responsible for this depletion are unclear. Through careful inspection of the spleens and lymph nodes (LNs) from six cases with postmortem examinations, we observed that SARS-CoV-2 could directly infect secondary lymphoid organs to induce cell death. Immunohistochemistry demonstrated ACE2 (angiotensin-converting enzyme 2), the potential receptor of SARS-CoV-2, expresses on tissue-resident CD169+macrophages in spleens and LNs. Immunofluorescent staining confirmed that viral nucleocaspid protein (NP) can be found in ACE2+cells, CD169+macrophages, but not in CD3+T cells or B220+B cells in spleens and LNs. SARS-CoV-2 infection induces severe tissue damage including lymph follicle depletion, splenic nodule atrophy, histiocyte hyperplasia and lymphocyte reductions. Moreover,in situTUNEL staining illustrated that viral infection leads to severe lymphocyte apoptosis, which might be mediated by viral antigens inducing Fas upregulation. Furthermore, SARS-CoV-2 also triggers macrophages to produce IL-6, a proinflammatory cytokine that directly promotes lymphocyte necrosis. Collectively, these results demonstrate that SARS-CoV-2 directly neutralizes human spleens and LNs through infecting tissue-resident CD169+macrophages.
In vivophotopharmacology enabled by multifunctional fibers
Authors: Frank James A. , Antonini Marc-Joseph , Chiang Po-Han , Canales Andres , Konrad David B. , Garwood Indie , Rajic Gabriela , Koehler Florian , Fink Yoel , Anikeeva Polina 
Published: March 2020

ABSTRACTTo reversibly manipulate neural circuits with increased spatial and temporal control, photoswitchable ligands can add an optical switch to a target receptor or signaling cascade. This approach, termed photopharmacology, has been enabling to molecular neuroscience, however, its application to behavioral experiments has been impeded by a lack of integrated hardware capable of delivering both light and compounds to deep brain regions in moving subjects. Here, we devise a hybrid photochemical genetic approach to target neurons using a photoswitchable agonist of capsaicin receptor (TRPV1),red-AzCA-4. Using the thermal drawing process we created multifunctional fibers that can deliver viruses, photoswitchable ligands, and light to deep brain regions in awake, freely moving mice. We implanted our fibers into the ventral tegmental area (VTA), a midbrain hub of the mesolimbic pathway, and used them to deliver a transgene coding for TRPV1. This sensitized excitatory VTA neurons tored-AzCA-4, and allowed us to optically control conditioned place preference using a mammalian ion-channel, thus extending applications of photopharmacology to behavioral experiments. Applied to endogenous receptors, our approach may accelerate studies of molecular mechanisms underlying animal behavior.