bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Comparison of Adding Sulfate Magnesium and Dexmedetomidine in Axillary Plexus Block for Prolonging the Duration of Sensory and Motor Block: Study Protocol for a Double-blind Randomized Clinical Trial
Authors: Shahtaheri Seyed Yousef , Rad Mohammad Tavakoli , Yazdi Bijan , Azami Mehran , Kamali Alireza 
Published: March 2020

Background: The purpose of this study was to compare the effect of magnesium sulfate adjunct to dexmedetomidine on increasing the duration of sensory and motor block in axillary block.
&nbsp;
Materials and methods: This study is a double-blind clinical trial. Ninety-nine patients were included in the study. They were undergoing forearm and hand surgery and were referred to Vali-e-Asr Hospital in Arak. The patients were divided into three groups. The first group received lidocaine (1.5%) and dexmedetomidine (0.5 &mu;g/kg). The second group patients were given lidocaine (1.5%) plus magnesium. In the control group, lidocaine &nbsp;(1.5%) was adjusted to 35 cc with normal saline. The final volume was 35 cc in the three groups. Sensory and motor block and pain were measured and data were analyzed using SPSS v. 20. The final volume was 35 cc in the three groups.
&nbsp;
Results: The sensory and motor block onset time and the stabilization time of the sensory and motor block in the magnesium sulfate group were lower (p<0/001). Pain in recovery, 2, 4, 6, 12, and 24 hours after surgery was lower in the magnesium sulfate group when compared with the dexmedetomidine group (p<0.001). The lowest dose of opioid was used in the dexmedetomidine group 24 hours after surgery (p<0.001).
&nbsp;
Conclusion: The results showed that dexmedetomidine decreases pain. Magnesium sulfate increased the sensory and motor block onset time, and the sensory and motor block stabilization time, but dexmedetomidine increases the motor block duration.
Peak Responses during Exercise Treadmill Testing using Individualized Ramp Protocol and Modified Bruce Protocol in Elderly Patients
Authors: Kozlov Sergey , Caprnda Martin , Chernova Olga , Matveeva Marina , Alekseeva Irina , Gazdikova Katarina , Gaspar Ludovit , Kruzliak Peter , Filipova Slavomira , Gabbasov Zufar 
Published: March 2020

Background: Exercise capacity is well known to be an important prognostic factor in patients with cardiovascular disease and among healthy persons.
&nbsp;
Aim: To determine if there are any differences between the peak exercise response during exercise treadmill testing with the individualized ramp protocol and the modified Bruce protocol in elderly patients.
&nbsp;
Materials and methods: The study included 40 patients (both male and female), aged 70 years and older, who had not had a baseline history of the confirmed coronary artery disease or heart failure diagnoses. All patients underwent exercise treadmill testing using modified Bruce protocol and individualized ramp protocol for 2 consecutive days. Peak heart rate, peak systolic and diastolic blood pressure, peak pressure-rate double product, exercise duration, and peak metabolic equivalents were recorded in both tests. Perceived level of exertion was evaluated using the Borg 10-point scale.
&nbsp;
Results: The average duration of exercise was longer for the ramp protocol than for the modified Bruce protocol. When the modified Bruce protocol was used, patients achieved a lower workload than they did in using the ramp protocol. The rating of perceived exertion using the revised Borg scale (0 to 10) was 5.6&plusmn;1.4 for the ramp protocol and 8.7&plusmn;1.4 for the modified Bruce protocol, which indicates that the patients found the ramp protocol easier.
&nbsp;
Conclusion: In elderly patients the individualized ramp treadmill protocol allows to achieve the optimal test duration with higher degrees of workload and greater patient comfort during the test more often than does the modified Bruce protocol.
Evidence-Based Practice for Cardiac Intensive Care Unit Nurses: An Educational Intervention Study
Authors: Rostamnia Leili , Ghanbari Vahid , Shabani Fidan , Farahani Abbas , Dehghan-Nayeri Nahid 
Published: March 2020

Background:
This study examined the effectiveness of two educational methods on nurses' skills and commitment to implementing evidence-based practice (EBP).

Method:
Ninety nurses were randomly assigned to three groups. Participants in the workshop group took part in a 2-day training course, participants in the multimedia group received educational content through video, and participants in the control group did not receive any training content. The nurses' skills and commitment to implement EBP were assessed at baseline and 1 month after the teaching sessions.

Results:

The EBP skills of nurses in the intervention groups were significantly enhanced compared with nurses in the control group (
p
< .05). Mean scores in the multimedia group were slightly better than in the workshop group; however, this difference was not statistically significant. Commitment to EBP implementation did not change significantly over time among the groups (
p
> .05).

Conclusion:

Different methods of training can be useful in improving nurses' EBP skills; however, the participants' commitment to implement EBP did not change considerably. Because of its cost effectiveness, the multimedia method should be considered for use in nurse training.

[
J Contin Educ Nurs
. 2020;51(4):167–173.]
Information Technologies: Leading Innovative Factor for the Development of Independent Tourism
Authors: Polukhina Anna , Tarasova Anna , Arnaberdiyev Avdykerim 
Published: March 2020

<p>Independent travel has blossomed and become an important movement in modern tourism. However, past research has never explored the use and impact information and communication technologies have on independent tourists.</p><p>The purpose of the research is to analyze the results of two surveys held in the Russian Federation that show the way different travel search engines, booking systems change the concept of modern tourism. This study illustrates that independent vacation planning is booming today’s travel market, which is becoming more personalized, digitalized and independent from giant tour operators. The article discusses how internet users’ requests in the search engines have changed within only one year and how these changes influenced people choice of accommodation and destination.</p>
Élites municipales et manufacture en Italie
Authors: Morel Jean-Paul 
Published: March 2020

En dépit des réticences des sources antiques et dans le cadre des débats actuels, on peut s’interroger sur le rapport des élites municipales italiennes à la manufacture. Quel était leur rôle dans ces productions ? Et quel profit leur apportaient celles-ci ? Un “camouflage” évident laisse percer la participation des élites à des activités réputées ignominieuses, mais souvent lucratives, dont seules sont “avouées” celles qui ont un lien au moins théorique avec la propriété foncière.
Due casi di committenza sacra ad Aquileia
Authors: Fontana Federica 
Published: March 2020

L’analisi del materiale epigrafico ed archeologico del contesto sacro di Monastero di Aquileia ha portato ad individuare sul frontone fittile del tempio Apollo, Artemide ed un’altra figura di tipo matronale (Athena; Latona?), cui si associavano, probabilmente come figure marginali, Borea ed Orizia, il cui mito è tradizionalmente legato, nell’Atene di V sec. a.C., all’imperialismo marittimo seguito alla vittoria sui Persiani. La coppia di Apollo e Diana sembra avere, anche ad Aquileia, caratteristiche spiccatamente anti-barbariche. L’atto dedicatorio di Tampia, invece, relativo ad un sacello a Diovis, rivela il probabile intento di recuparare un culto proprio della zona di origine della sua gens, Praeneste.
“Magis alii homines...”
Authors: Perrin Yves 
Published: March 2020

Une étude des origines des consuls néroniens montre que les plus hautes sphères de la société et de l’Etat sont dominées par les notables italiens. Le renouvellement de l’élite ne se fait pas au profit des familles qui ont fondé le régime impérial, mais à celui del boni italiens qui en ont géré l’affermissement depuis Tibère. La nobilitas julio-claudienne et les homines novi néroniens forment un groupe qu’on peut opposer à celui de la nobilitas républicaine et césaro-augustéenne. D’où une hypothèse : le clivage éthico-politique au sein du premier ordo constitue le fondement de la nature monarchique du régime.
Producir más alimentos de forma sostenible es posible: Fertilización biotecnológica y sostenible ante el problema del crecimiento poblacional
Authors: Del Pozo Juan Carlos 
Published: March 2020

El gran aumento de la población mundial previsto para este siglo obligará a incrementar la producción agrícola de forma proporcional para asegurar la alimentación. Sin embargo, actualmente la sociedad demanda nuevos métodos de producción más sostenibles y respetuosos con el medio ambiente. Para poder obtener este incremento sostenible es necesario hacer uso de las nuevas herramientas biotecnológicas, como la edición génica o la biología sintética, y del conocimiento generado por los investigadores durante años. El microbioma del suelo está emergiendo como una poderosa herramienta biotecnológica. Estos microorganismos beneficiosos promueven el crecimiento vegetal a través del aporte de nutrientes, producción de hormonas o metabolitos secundarios. Por ello, el uso de estos microrganismos ayudará a incrementar la producción agrícola de forma sostenible.
Identification of core genes associated with prostate cancer progression and outcome via bioinformatics analysis in multiple databases
Authors: Wang Yutao , Wang Jianfeng , Yan Kexin , Lin Jiaxing , Zheng Zhenhua , Bi Jianbin 
Published: March 2020

AbstractThe morbidity and mortality of prostate carcinoma has increased in recent years and has become the second most common ale malignant carcinoma worldwide. The interaction mechanisms between different genes and signaling pathways, however, are still unclear.MethodsVariation analysis ofGSE38241,GSE69223,GSE46602andGSE104749were realized by GEO2R in Gene Expression Omnibus database. Function enrichment was analyzed by DAVID.6.8. Furthermore, the PPI network and the significant module were analyzed by Cytoscape, STRING and MCODE.GO. Pathway analysis showed that the 20 candidate genes were closely related to mitosis, cell division, cell cycle phases and the p53 signaling pathway. A total of six independent prognostic factors were identified inGSE21032and TCGA PRAD. Oncomine database and The Human Protein Atlas were applied to explicit that six core genes were over expression in prostate cancer compared to normal prostate tissue in the process of transcriptional and translational. Finally, gene set enrichment were performed to identified the related pathway of core genes involved in prostate cancer.ResultHierarchical clustering analysis revealed that these 20 core genes were mostly related to carcinogenesis and development. CKS2, TK1, MKI67, TOP2A, CCNB1 and RRM2 directly related to the recurrence and prognosis of prostate cancer. This result was verified by TCGA database andGSE21032.ConclusionThese core genes play a crucial role in tumor carcinogenesis, development, recurrence, metastasis and progression. Identifying these genes could help us to understand the molecular mechanisms and provide potential biomarkers for the diagnosis and treatment of prostate cancer.
Plantar support adaptations in healthy subjects after eight weeks of barefoot running training
Authors: Sánchez-Ramírez Celso , Alegre Luis M. 
Published: March 2020

BackgroundAlthough the studies of barefoot running have intensified, it is still missing longitudinal work analyzing the effects of barefoot running on the phases of plantar support. The objective of this research was to analyze the modifications undergone by the Total Foot Contact (TFC) phase and its Flat Foot Phase (FFP) in subjects beginning the practice of barefoot running, in its acute and chronic effects.MethodsA total of 28 subjects were divided into the Barefoot Group (BFGr) (n= 16) and the Shod Group (SHGr) (n= 12), evaluated before (Baseline) and after running for 20 min at 3.05 m·s−1(Post 20 min Running), and at the end of a running training protocol with an 8-week long progressive volume (Post-8-week Training). The dynamic plantar support was measured with a baropodoscope. The duration of TFC (ms), the moment at which the FFP occurred, the maximum surface of TFC (MSTFC) (cm2), the FFP surface (SFFP) (cm2), the peak pressure of TFC (PP°TFC) (kg·cm−2), and the peak pressure of FFP (PP°FFP) (kg·cm−2) were recorded. The 3 × 2 ANOVA analysis was made to determine the effects and interactions that the condition produced (Shod/Barefoot), and the time factor (Baseline/Post 20 min Running/Post-8-week Training).ResultsThe condition factor caused more significant effects than the time factor in all the variables. Duration of TFC in BFGr showed significant differences between the Baseline and Post-8-week Training (p= 0.000) and between Post-20-min Running and Post-8-week Training (p= 0.000), with an increasing trend. In the moment at which the FFP occurred a significant increase (p= 0.029) increase was found in Post-20 min Running (48.5%) compared to the Baseline (42.9%). In MSTFC, BFGr showed in Post-8-week Training values significantly higher than the Baseline (p= 0.000) and than Post-20-min Running (p= 0.000). SHGr presented a significant difference between the Baseline and Post-8-week Training (p= 0.040). SFFP in BFGr modified its values with an increasing trend (p= 0.000). PP°TFC in BFGr showed a significant decrease (p= 0.003) in Post-8-week Training (1.9 kg·cm−2) compared to the Baseline (2.4 kg·cm−2). In PP°FFP significant decreases were recorded in BFGr and between Post-8-week Training and Baseline (p= 0.000), and Post-8-week Training and Post 20 min Running (p= 0.035).ConclusionsThe adaptation took place after the 8-week training. The adaptations to running barefoot were characterized by causing an increase of the foot’s plantar support in TFC and in FFP, as well as a decrease of the plantar pressure peak in both phases. Also, there is an increased duration of the TFC and FFP, which may be related to an acquired strategy to attenuate the impacts of the ground’s reaction forces.
Health Information Analysis of Bank OCBC NISP 2015 - 2019
Authors: Mulyadi Hanafi , Virgana T. S. Rae 
Published: March 2020

Aims: Examine the health information of OCBC NISP banks between the relationship of ratio data finance ROA (Return on Assets) between the relationship ROA, NPL, LDR and BOPO data.
Study Design: Statistical methods using the dependent variable is ROA (Return on Assets) and the independent variables namely NPL (Non-Performance Loan), LDR (Loan to Deposit Ratio), and BOPO (Operating Expenditures Operation Income) Data as health information analyzes Quarterly Data from 2015-2019
Place and Duration of Study: Information Systems, Faculty of Engineering, University Widyatama The research was Carried out between October 2019 to January 2020.
Methodology: Collecting the data in this study tries to analyze information between related the data relationships of NPL (Non-Performance Loan), LDR (Loan Deposit Ratio), and BOPO (Operating Expenditures Operation Income) to ROA (Return on Assets) on the bank OCBC NISP in the period 2015-2019 and using the fixed effects method.
Results: The results of this study NPL positive effect on ROA significant with a p-value of 0.6997, the coefficient NPL = +0.0536262, so any increase is in NPL 1% then the the resulting rise in ROA of 0.0536262%. For LDR positive effect on ROA and very significant with a p-value of 0.4301, the coefficient NPL = +0.00210031, so any increase is in NPL 1% then the the resulting rise of 0.00210031% ROA, and vice versa. To BOPO negative effect on ROA significant with a p-value of 0.0002, the coefficient of BOPO = -0.0793051, so any increase is in ROA of 1% then result in a Decrease of 0.0793051% ROA and vice versa.
Conclusion: The correlation between the independent ROA relationship to the NPL, LDR and ROA is related to the bank's health analysis from the coefficient value shown on the R-squared value of 0.980778 to describe a set of independent variables and the dependent variable explained by 98%.
Chemotherapeutic Interaction of Vernonia amygdalina (Delile) Leaf Extract with Artesunate and Amodiaquine in Murine Malaria Model
Authors: Osirim Esthinsheen , Adeyemi Oluwole I. , Igbinoba Sharon I. , Onyeji Cyprian O. 
Published: March 2020

Aim of the Study: Conventional antimalarial drugs are used concurrently with herbal remedies in malarial endemic developing countries. Vernonia amygdalina is one of such popular herbs used in the treatment of malaria. This study aimed at investigating the antimalarial chemotherapeutic interaction of Vernonia amygdalina (VA) when combined with Amodiaquine (AQ) and/or Artesunate (AS) in a murine Plasmodium berghei malaria model.
Methodology: Various doses of aqueous VA leaf extract (100-500 mg/kg/day), AQ (2-10 mg/kg/day) and AS (0.8-4 mg/kg/day) were administered orally to P berghei.-infected Swiss albino mice to determine their sub-therapeutic doses. These doses were subsequently used to investigate the chemotherapeutic interactions of VA with AQ and/or AS in both early and established malaria infection test models. The survival of animals with established infections that received different drug/herb treatments were determined using their mean survival time (days) and Kaplan-Meier survival curves (percentage). Using GraphPad Instat (version 3.10) and PrismR (version 5.01) the data obtained were subjected to One-way ANOVA, followed by Student-Newman-Keuls test. P < .05 was considered statistically significant.
Results: The sub-therapeutic doses of VA, AQ and AS were found to be 100 mg/kg, 2 mg/kg and 2.4 mg/kg, respectively. The chemosuppressive effect of AQ or AS was significantly increased (p< 0.05) when administered in combination with the VA extract. Similarly, combination of VA extract with AQ or AS resulted in significant (P < .05) parasite clearance when compared to the effects of the herb or the conventional drugs administered separately. The mean survival period of animals with established infection was also significantly enhanced by the VA alone or with AQ (or AS) compared to placebo.
Metagenomic Mining for Amine Dehydrogenase Discovery
Authors: Caparco Adam A. , Pelletier Eric , Petit Jean Louis , Jouenne Aurélie , Bommarius Bettina R. , de Berardinis Véronique , Zaparucha Anne , Champion Julie A. , Bommarius Andreas S. , Vergne‐Vaxelaire Carine 
Published: March 2020

AbstractAmine dehydrogenases (AmDHs) catalyze the enzymatic reduction of ketones to amines, serving as a suitable biocatalytic route for amine synthesis. A limited number of experimentally validated native AmDHs (nat‐AmDHs) have been reported recently, expanding the sequences with this function to complement the small set of engineered enzymes. Since researchers can now probe into the vast diversity of enzymes within niche environments by a metagenomics approach, a tandem metagenomic and bioinformatic approach is a powerful tool to identify new members of limited enzyme families to access new features in an iterative fashion. The previously untapped biocatalytic reservoirs of the ocean environment and human microbiome were screened for potential AmDHs using a hidden Markov model. Among the hundreds of hits, a subset of 18 enzymes was selected for further characterization and were confirmed to display AmDH activity. Additional analysis on six enzymes confirmed altered cofactor specificities and variation in substrate scopes, catalytic efficiencies, and active site residues compared to the reference nat‐AmDHs previously described. Particularly, MATOUAmDH2 from an eukaryotic organism demonstrated specific activity of 11.07 and 0.88 U mg−1 toward isobutyraldehyde and 1,2‐cyclohexadione respectively. Their abundance among the screened environments was also described. The protein sequence diversity of validated AmDHs reached by this metagenomics mining strategy highlights the success of such an approach. Metagenomically mined proteins, including eukaryotic ones, stand to increase the reach of biocatalysis towards enviromentally benign processes.magnified image
Ibotenic Acid Biosynthesis in the Fly Agaric Is Initiated by Glutamate Hydroxylation
Authors: Obermaier Sebastian , Müller Michael 
Published: March 2020

AbstractThe fly agaric, Amanita muscaria, is widely known for its content of the psychoactive metabolites ibotenic acid and muscimol. However, their biosynthetic pathway and the respective enzymes are entirely unknown. 50 years ago, the biosynthesis was hypothesized to start with 3‐hydroxyglutamate. Here, we build on this hypothesis by the identification and recombinant production of a glutamate hydroxylase from A. muscaria. The hydroxylase gene is surrounded by six further biosynthetic genes, which we link to the production of ibotenic acid and muscimol using recent genomic and transcriptomic data. Our results pinpoint the genetic basis for ibotenic acid formation and thus provide new insights into a decades‐old question concerning a centuries‐old drug.
Iridium(III) Catalysts with an Amide‐Pendant Cyclopentadienyl Ligand: Double Aromatic Homologation Reactions of Benzamides by Fourfold C−H Activation
Authors: Tomita Eiki , Yamada Kodai , Shibata Yu , Tanaka Ken , Kojima Masahiro , Yoshino Tatsuhiko , Matsunaga Shigeki 
Published: March 2020

AbstractThe synthesis, characterization, and catalytic performance of iridium(III) catalysts that bear an amide‐pendant cyclopentadienyl ligand ([CpAIrI2]2) is reported. These [CpAIrI2]2 catalysts were obtained from the complexation of a CpA ligand precursor with [Ir(cod)OAc]2 followed by oxidation. Double aromatic homologation reactions of benzamides with alkynes by fourfold C−H activation proceeded in good to high yield with these [CpAIrI2]2 catalysts, demonstrating their superior catalytic performance in this challenging transformation.
Hydrophobic Monomers Recognize Microenvironments in Hydrogel Microspheres during Free‐Radical‐Seeded Emulsion Polymerization
Authors: Watanabe Takumi , Nishizawa Yuichiro , Minato Haruka , Song Chihong , Murata Kazuyoshi , Suzuki Daisuke 
Published: March 2020

AbstractThe three‐dimensional structure of nanocomposite microgels was precisely determined by cryo‐electron micrography. Several nanocomposite microgels that differ with respect to their nanocomposite structure, which were obtained from seeded emulsion polymerization in the presence of microgels, were used as model nanocomposite materials for cryo‐electron micrography. The obtained three‐dimensional segmentation images of these nanocomposite microgels provide important insights into the interactions between the hydrophobic monomers and the microgels, that is, hydrophobic styrene monomers recognize molecular‐scale differences in polarity within the microgels during the emulsion polymerization. This result led to the formation of unprecedented multi‐layered nanocomposite microgels, which promise substantial potential in colloidal applications.
Chitin nanocrystals reticulated self‐assembled architecture reinforces deproteinized natural rubber latex film
Authors: Hu Jiarui , Tian Xiaohui , Sun Jinyu , Yuan Jianyong , Yuan Yizhong 
Published: March 2020

AbstractNatural rubber (NR) latex was initially deproteinized, then, the interactions between chitin nanocrystals (ChNCs) and deproteinized natural rubber (DNR) latex particles in an aqueous system and the properties of DNR/ChNCs composites were investigated. Composite films were obtained by casting and evaporating off the prevulcanized DNR/ChNCs complexation rather than simply mixing of DNR latex and ChNCs suspension. The results of DLS and TEM confirmed that this kind of complexation was formed between negative charged DNR and positively charged ChNCs by self‐assembly. The tensile strength of composite films containing 4 wt% ChNCs was 25.00 ± 1.42 MPa, which was 3.11 multiples of the pure pre‐vulcanized DNR. DNR/ChNCs composite films could provide excellent mechanical properties and avoid allergies caused by proteins in NR latex.