bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anticancer Potential of Ficus religiosa (Linn) Against Human Breast Cancer Cell Line MDA-MB-231 and its Phytoconstituents by HR-LCMS
Authors: Shaikh Ayesha , Patel Muftedar , Padul Manohar 
Published: December 2020

Abstract
Background: Ficus religiosa is widely present in India especially in northern region and has been traditionally used for various indications. We investigated the anticancer potential of leaf extract against human breast cancer cell line MDA-MB-231. The anticancer potential was further supported by identifying potential phytoconstituents of the extract by HR-LCMS analysis.Methods: Amongst the collected fractions, subfraction of chloroform was selected for anticancer screening in parallel for identification of phytochemicals by using HR-LCMS. Extract showed positive results in a battery of two tests employed in the current study by using MDA-MB231 breast cancer cell lines. In trypan blue exclusion dye test, 50% of cell killing was observed at 110 µg/ML. In vitro anticancer activity by using SRB assay showed dose dependent growth inhibition at 62.5, 125, 250 and 500 µg/mL concentrations. The parameters LC50, GI and TGI50 found from the assay were 100, 200, 300 µg/mL respectively. Assay parameter In case of HR-LCMS analysis several active phytochemicals were identified in the extract.Results: F. religiosa leaf extract showed promising anticancer activity against human breast cancer cell MDA-MB-231. Conclusion: F. religiosa leaf extract has promising anticancer potential against human breast cancer cells MDA-MB-231 and numerous phytochemicals further warrants evaluating it for multi-therapeutic potential.
Comparing Low and High-Temporal Resolution DCE-MRI Texture Analysis for Discrimination of Breast Lesions from Background Enhancement
Authors: Liu Yufeng , Li Jiaying , Qu Jingjing , Tang Rui , Lv Kun , Wang Chundan , Xiao Fengchun , Zhou Jiali , Ge Min , Ding Xuewei , Ding Hong , Wang Shiwei , Xu Maosheng 
Published: December 2020

Abstract
Background

Breast cancer is the most common cancer in women worldwide, high-resolution dynamic contrast-enhanced MRI (DCE-MRI) can better evaluate the tissue microenvironment and texture characteristics. The purpose of this study was to investigate the value of the texture-based analysis for breast DCE-MRI in the diagnosis of breast lesions and background enhancement.
Methods

This study prospectively enrolled 128 patients with clinically suspected breast lesions in our hospital from April 2015 to June 2017. Among them, 62 patients underwent preoperative high temporal resolution DCE-MRI (1 + 26 phases) scan with 39 malignant and 23 benign lesions. The control group retrospectively and randomly contained 78 patients who underwent preoperative low temporal resolution DCE-MRI (1 + 5 phases) scans with 46 malignant and 32 benign lesions. Quantitative parameters were obtained using a two-compartment Extended Tofts and volume of interest model for the lesion center, surrounding peripheral area and background enhancement, including pharmacokinetic parameters (Ktrans, Kep, Ve and Vp) and texture features based on the Ktrans map. The Student’s t-test was used to compare the differences of means. LASSO was used for dimension reduction and logistic regression analysis was used for model construction. A receiver operating characteristic (ROC) analysis was used to evaluate the diagnostic performance.
Results

Pharmacokinetic parameters were significantly different between high temporal resolution and low temporal resolution DCE-MRI (P < 0.05). In the malignant group, the average Ktrans of the lesion area on high temporal resolution DCE-MRI was significantly correlated to the pathological grading (r = 0.400, P = 0.012). In the differentiation between benign and malignant lesions, the ROC analysis demonstrated that the diagnostic value of high temporal resolution DCE-MRI offered slightly significant advantages in the realms of the lesion, peripheral areas and background enhancement.
Conclusions

The use of texture analysis based on high temporal resolution DCE-MRI may potentially improve breast cancer diagnostic performance. Specifically, combining the lesion, peripheral, BE area, and Ktrans-mean parameters can contribute to the diagnosis of breast lesions, background enhancement and the pathological grading of malignant tumors.
El archivo joven
Authors: Luna Rodríguez Guadalupe E. 
Published: December 2020

<p class="p1">Los archivos de arquitectura se diferencian de los otros desde su generación hasta su conservación. Es posible analizar el comportamiento y las posibilidades de colaboración entre diferentes archivos que resguardan acervos físicos de finales del siglo <span class="s2">xix </span>y principios del <span class="s2">xx </span>con el uso de las herramientas digitales contemporáneas. La generación de conocimiento se relaciona con la posibilidad de visitar los acervos, pero con el uso de la tecnología digital contemporánea la movilidad ya no restringe la investigación. Este cambio en la manera de generar y divulgar el conocimiento modificará inevitablemente la conformación de los archivos futuros, pues los acervos ya no serán seleccionados por su valor, sino que quedarán inmersos en la vastedad del internet esperando a ser encontrados.<span class="Apple-converted-space"> </span></p>
Funciones cognitivas en la descendencia de pacientes con trastorno bipolar I
Authors: Bertieri Arcila Humberto Carlos , Julio De La Rosa Adonilso , Lemos Buitrago Rocío 
Published: December 2020

Objetivo: Describir las características neuropsicológicas de niños y adolescentes descendientes de padres con antecedentes de TB I, respecto a la aplicación de una prueba estandarizada de inteligencia.
Materiales y métodos: Estudio observacional descriptivo de corte transversal, en donde los autores investigaron el Coeficiente Intelectual Total; Índice de compresión verbal; Índice de Razonamiento Perceptual; Índice de Memoria de trabajo; Índice de Velocidad de Procesamiento. Se evaluaron (n=30) descendientes al aplicar varias subpruebas de la Escala de inteligencia de Weschler para niños, (WISC –IV).
Resultados: El Coeficiente Intelectual Total de los participantes con un 63,3% está por debajo del promedio de la curva de distribución normal, según la estandarización del test de inteligencia aplicado. Clasificando la tendencia de la muestra como un promedio normal bajo, en cuanto a la muestra evaluada. Los índices de memoria de trabajo y compresión verbal fueron las funciones cognitivas con puntuaciones más bajas en la muestra.
Discusión: Nuestros hallazgos sugieren un riesgo en hijos de pacientes con TBI, que puede contribuir a un incremento cuantitativo de las alteraciones cognitivas, especialmente el índice de memoria de trabajo y compresión verbal. Estos hallazgos pueden sugerir un posible endofenotipo del TB I y su descendencia, en relación a la presentación temprana de alteraciones cognitivas en este grupo de riesgo. Dichos hijos podrían ser un punto de partida para realizar estudios que determinen predicción y realizar así un abordaje temprano.
Tantangan Dan Peluang Penerapan Kebijakan Mandatory Sertifikasi Halal (Studi Implementasi Uu No. 33 Th. 2014 dan Pp No. 31 Th. 2019)
Authors: Muhamad Muhamad 
Published: December 2020

Penelitian bertujuan untuk mengetahui peluang dan tantangan dengan adanya penerapan kebijakan mandatory sertifikasi halal setelah pengeluaran UU No.33 Th 2014 dan PP No. 31 Th 2019. Penelitian ini dilakukan dengan menggunakan jenis penelitian mixed yaitu penelitian lapangan dan penelitian hukum, dengan pendekatan pendekatan eksploratoris. Teknik pengumpulan data yang digunakan adalah teknik: Wawancara, dokumentasi dan observasi. Data yang dikumpulkan di olah dan dianalisis dengan menggunakan analisis kualitatif dengan tahapan analisis; pemeriksaan Data (editing), penandaan data (coding), dan penyusunan data (constructing/systematizing). Hasil penelitian menunjukkan bahwa partisipasi pelaku UMKM terkait dengan pelaksanaan kebijakan mandatory sertifikasi halal masih rendah. Kemudian tantangan yang dihadapi UMKM dengan adanya kebijakan mandatori sertifikasi halal, dimulai dari: a) Kebijakan sertifikasi halal memberikan tuntutan bagi pelaku usaha agar produknya tersertifikasi halal; b) Persyaratan kelengkapan dokumen yang harus dilengkapi UMKM; c) Modal yang minim yang dimiliki dan belum beraninya berproyeksi dengan modal pinjaman menjadikan ada ketergantungan pelaku usaha khususnya mikro-kecil kepada pemerintah; d) Proses yang masih manual dan belum menggunakan aplikasi online; e) Pemenuhan kriteria halal terkait bagaimana pelaku usaha mempersiapkan bahan, produk, fasilitas produksi, prosedur tertulis untuk aktivitas kritis, dan kemampuan telusur; f) Masalah dalam internal UMKM termasuk rendahnya SDM yang dimiliki menjadikan rasa malas dan tidak antusias terhadap kebijakan yang diberlakukan (UMKM kurang tergerak mandiri) dan g) Paradigma pelaku usaha: sertifikasi halal bagi perusahaan yang beromset besar.
Equilibrium and Kinetic Studies of Liquid Phase Adsorption of Methylene Blue Onto Phosphoric Acid Modified Bambaranut Shell
Authors: Olivia Eze Nkechinyere , Adimchinobi Ejimofor Samuel , Uzoma Onuegbu Theresa 
Published: December 2020

Abstract
In view of the global need to curb the effect of contaminants in waste water on our environment, the adsorption potentials of modified carbon from bambaranut (Vigna subterranean) shell was investigated for its efficiency in the removal of methylene blue from waste water. The adsorbent morphology and surface chemistry were established by Brunauer-Emmett-Teller (BET) determination and Scanning Electron Microscopy (SEM), as well as other standard laboratory procedures. The prepared material was used for the uptake of MB from aqueous solution in a batch process, using UV spectrophotometer Model 752 at 620nm to analyze for the residual dye concentration. The effect of operational parameters such as contact time, adsorbent dosage, initial dye concentration and pH were analyzed to determine the factors controlling the rate of adsorption. Results from the study showed that the active carbon prepared was a porous material, with surface area of 193 m2/g, average pore size of about 10.98nm, and pore volume of 0.530cm3/g. With increase in initial dye concentration from 15mg/l to 75mg/l, a decrease in percent adsorption from 95.4% to 72.19% was observed. Increase in adsorbent dosage (from 0.1g to 0.5g), contact time (from 5 min to 40 min) and pH from 2 to 10 resulted in increase in percent adsorption from 84.03% to 98.83%, 54.24% to 84% and 48.17% to 84.03% respectively. About 98.83% removal of MB dye was achieved after 20 min, at pH of 6, temperature of 27±2oC, 0.5g weight of adsorbent and initial concentration of 60mg/l of 50ml MB dye solution. Langmuir isotherm best fits the equilibrium adsorption data with R2 = 0.996; the adsorption intensity obtained from Freundlich model (n>1) and the energy of adsorption obtained from the D-R model (< 8kJ/mol) suggested that physisorption dominates the adsorption of methylene blue onto the prepared activated carbon. Adsorption kinetic data was best described using Pseudo second order kinetic model (R2 = 0.996), giving equilibrium rate constant (k2) of 7690g mg-1 min-1. The characteristic results showed that bambaranut shell can be employed as an alternative to commercial adsorbents in the removal of methylene blue dye from aqueous solutions and waste water.
Comparative Effects of Different Organic and Inorganic Fertilisers on Soil Fertility, Plant Growth, Soil Microbial Community, and Storage Ability of Lettuce
Authors: El-Mogy Mohamed M. , Abdelaziz Suzy M. , Mahmoud Abdel Wahab M. , Elsayed Tarek R. , Abdel-Kader Noha H. , Mohamed Mohamed I. A. 
Published: December 2020

Abstract
The current study was conducted to assess whether organic fertilisation could replace mineral fertilisation in lettuce production without adverse effects on yield, quality, and postharvest behaviour. The effect of either mineral or organic fertiliser on soil fertility or the microbial community was also studied. Control plots were fertilised with recommended rates of mineral fertiliser (150: 45: 65 kg/ha NPK) and the other treatments were 15 t/ha compost, 10 t/ha rabbit manure, and 10 t/ha chicken manure. Our results indicated that all sources of organic fertiliser significantly increased total nitrogen, organic carbon, total fungi, and bacteria contents of soils compared with mineral fertiliser. Rabbit and chicken manure fertilisers resulted in a significant increase in yield. Compared with conventional fertiliser and other organic treatments, plots receiving rabbit manure showed a lower weight loss and microbial load on fresh lettuce head. Moreover, rabbit manure significantly reduced polyphenol oxidase and peroxidase activity. Hence, these results suggest that rabbit manure fertiliser could be an alternative to conventional production without significant reduction in yield and with low enzymatic browning and better storability.
Buckling Analysis of Innovative Corrugated Column by using Response Surface Methodology
Authors: Rahim Mohd Reyaz Ur , Bharti Prem Kumar 
Published: December 2020

Abstract
Tubular steel structures with slender compression cross-sections are prone to local buckling. In this paper the axial compression is investigation of the innovative fabricated structural steel column consisting of sinusoidal corrugated pattern. When it comes to the design of compressive individuals, buckling is a crucial layout provision. The paper describes the effect of variation in the sectional properties like mean diameter, thickness, amplitude, and frequency of corrugation on the buckling axial load. A quadratic model was developed to correlate the independent variables for maximum buckling load by using central composite design (CCD) method. Subsequently ANOVA, a statistical tool is used to analyse and compare the different combinations and finding the most influential factor on buckling load. Response surface methodology is adopted to review the interaction models between the different combinations.
Methods in Complexity Analysis of Discrete Time Signals
Authors: Germán-Salló Zoltán , Germán-Salló Zoltán 
Published: December 2020

Abstract
Discrete time signals carry information about systems and their internal functional mechanisms which characterize their complexity. Complexity measures are strongly related to information content and evaluations have been made on various signals in many ways in last few years. This paper uses information theory estimates of complexity as different types of entropies in order to estimate the complexity of various time discrete synthesized signals. Results show that this kind of indices can be a useful tool in diagnostic, fault detection and further development.
Assessment of dental anxiety and the prevalence of dental caries in a group of 6-9 years old children.
Authors: Vlad Ramona , Stoica Oana Elena , Stoica Alexandra Mihaela , Monea Monica 
Published: December 2020

Abstract
Children`s dental anxiety is responsible for increasing dental health problems, as patients avoid seeking treatment. The aim of our study was to evaluate the level of dental anxiety and its correlation with dental health status in a group of children aged between 6-9 years.
Material and Methods. Our study included 56 children: first, they completed a questionnaire and then the decay-missing-filled teeth index was measured (DMFT).
Results. From a total of 59 children, 29 children had dental anxiety (51.78%) and the prevalence of caries was 69%. The mean and SD for the DMFT index was 1.76+/- 1.54 (2.04 +/- 1.98 for boys and 1.69 +/- 1.72 for girls, with p= 0.0391, p<0.05).
In conclusion, the level of dental anxiety can be reduced by frequent visits to the dental office. A favorable personal experience might help children increasing their confidence for dental treatment. There was a significant negative association between the value of filled teeth and the level of child's anxiety.
Use of discriminant analysis method to identify sex by morphological traits in adult rabbits in Nigeria
Authors: Rotimi Emmanuel Abayomi , Ati Maryam Hassana 
Published: December 2020

Abstract
Sex assessment plays an important role in rabbit production, but it can be very difficult to determine, especially in the young ones. In this study, canonical discriminant analysis was used to determine which of the morphological traits are the most effective in sex determination in rabbits. Data were taken on 160 rabbits and used for this study on body weight (BWG), body length (BDL), ear length (EAL), heart girth (HTG), and abdominal circumference (ABC). The results from the univariate analysis show manifestation of sexual dimorphism with higher values observed in females for all the morphometric measurements. The canonical discriminant analysis revealed that ABC was the most significant morphological trait as a discriminating variable between the sexes in rabbits. The discriminant function, D = – 8.673 + 1.865 BWG + 0.013 BDL + 0.291 EAL – 0.318 HTG + 0.463 ABC, obtained correctly classified 72.5% of individuals of rabbits. In conclusion, the abdominal circumference of the rabbits in a population could be an important tool for the conservation and improvement of the rabbits’ population.
BlockChain Platforms in Financial Services: Current Perspective
Authors: Bringas Pablo Garcia , Pastor-López Iker , Psaila Giuseppe 
Published: December 2020

Abstract

Background
BlockChain technology was invented to support bitcoin, currently the most popular virtual currency.

Objectives
The purpose of this paper is to investigate contemporary BlockChain platforms in financial services.

Methods/Approach
An unstructured literature review has been used.

Results
BlockChain in financial services is mostly associated with bitcoin exchange. However, this is a partial view of both BlockChain technology and its possible adoption for financial services: in fact, many BlockChain platforms are now available and many different financial services can be effectively supported by BlockChain platforms, even though they are not based on virtual-money exchange. Furthermore, people are attracted by the concept of smart contract, i.e., a contract that is automatically executed by computer technology, without human intervention.

Conclusions
The contribution of this paper is twofold: first of all, we introduce the four BlockChain platforms that are now most popular, discussing how they support the smart contract concept; second, we identify some typical categories of financial services, matching each of them with the platform that provides the best support for each category.
Intelligent Personal Assistant in Business-Context: Key-feature Evaluation for User Acceptance
Authors: Hüsson Daniel , Holland Alexander , Sánchez Rocío Arteaga 
Published: December 2020

Abstract

Background
The usage of intelligent personal assistants (IPA), such as Amazon Alexa or Google Assistant is increasing significantly, and voice-interaction is relevant for workflows in a business context.

Objectives
This research aims to determine IPA characteristics to evaluate the usefulness of specific functions in a simulated production system of an Enterprise Resource Planning (ERP) software. A new function called explanation-mode is introduced to the scientific community and business world.

Methods/Approach
As part of a design science research, an artefact, i.e. an add-on for speech-interaction in business software, was developed and evaluated using a survey among ERP users and researchers.

Results
In the area of IPA-features, the search-function and speech input for textual fields were recognised as most useful. The newly introduced feature, the explanation mode, was positively received too. There is no significant correlation between the usefulness of features and participant-characteristics, affinity to technology or previous experience with IPAs in a private context, which is in line with previous studies in the private environment leading to the conclusion that the task attraction is the most important element for usefulness.

Conclusions
Most of the participants agreed that the speech-input is not able to fully substitute standard input devices, such as a keyboard or a mouse, so the IPA is recognised as an addition to traditional input methods. The usefulness is rated high especially for speech-input for long text fields, calling up masks and search-functions.
Molecular Detection and Genetic Analysis of Theileria equi Detected in Apparently Healthy Horses in Nigeria
Authors: Takeet M. I. , Ademola I. O. , Adejinmi J. O. , Mosaku E. I. , Abakpa S. A. V. , Peters S. O. 
Published: December 2020

Abstract
Equine theileriosis, an apicomplexan debilitating tick-borne parasitic disease of horses has caused considerable havoc to equine production all over the world. There is a dearth of information on the molecular characteristic of the parasites, Theileria equi Laveran, 1901, in Nigeria. Thus, in this study microscopy techniques and PCR were used to detect the T. equi of horses in Ogun, Oyo and Lagos States of Nigeria. We also characterized the partial region of 18S ribosomal RNA gene by sequencing and sequences analysis. One hundred and two horses consisting of Argentine 34 (33.3 %), Sudanese 21 (20.6 %) and local breeds 47 (46.1 %) including 2 females and 100 males were randomly sampled from the Polo Clubs in Ibadan, Lagos and from privately owned horse stables in Abeokuta. Blood samples were collected from the jugular vein, thin smears were prepared and stained with a field stain. The DNA was extracted from the blood and a partial region of the 18S ribosomal RNA gene was amplified. The amplified products were sequenced unidirectionally and subjected to phylogenetic analysis with those sequences obtained from the Gen-Bank. Of the 102 horses tested, 12 (11.7 %) were positive for T. equi by microscopy which included 9 (19.1 %) local breeds, 2 (5.8 %) Argentine breed and 1 (4.8 %) Sudanese breed. In contrast, 7 (6.8 %) were positive by the PCR method; out of which 5 (10.6 %) of these samples were from the local breed of horses while the remaining 2 (5.8 %) were from the Argentine breed. The Packed Cell Volume (PCV) of the infected and non-infected horses did not show any significant (P < 0.05) difference. The sequences lengths obtained were 311 bp and they had 97.43—98.07 % homologies with available sequences in the GenBank. The phylogenetic analysis of the sequences suggested that the strain of T. equi detected in the study area formed a new genotype different from the established genotypes around the world. In conclusion, the prevalence of T. equi was very low in the study area and one strain of the parasite may be in circulation among the studied horses.