bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum- and glucocorticoid- inducible kinase 2, SGK2, is a novel autophagy regulator and modulates platinum drugs response in cancer cells
Authors: Ranzuglia Valentina , Lorenzon Ilaria , Pellarin Ilenia , Sonego Maura , Dall’Acqua Alessandra , D’Andrea Sara , Lovisa Sara , Segatto Ilenia , Coan Michela , Polesel Jerry , Serraino Diego , Sabatelli Patrizia , Spessotto Paola , Belletti Barbara , Baldassarre Gustavo , Schiappacassi Monica 
Published: August 2020

AbstractFor many tumor types chemotherapy still represents the therapy of choice and many standard treatments are based on the use of platinum (PT) drugs. However, de novo or acquired resistance to platinum is frequent and leads to disease progression. In Epithelial Ovarian Cancer (EOC) patients, PT-resistant recurrences are very common and improving the response to treatment still represents an unmet clinical need. To identify new modulators of PT-sensitivity, we performed a loss-of-function screening targeting 680 genes potentially involved in the response of EOC cells to platinum. We found that SGK2 (Serum-and Glucocorticoid-inducible kinase 2) plays a key role in PT-response. We show here that EOC cells relay on the induction of autophagy to escape PT-induced death and that SGK2 inhibition increases PT sensitivity inducing a block in the autophagy cascade due to the impairment of lysosomal acidification. Mechanistically we demonstrate that SGK2 controls autophagy in a kinase-dependent manner by binding and inhibiting the V-ATPase proton pump. Accordingly, SGK2 phosphorylates the subunit V1H (ATP6V1H) of V-ATPase and silencing or chemical inhibition of SGK2, affects the normal autophagic flux and sensitizes EOC cells to platinum. Hence, we identified a new pathway that links autophagy to the survival of cancer cells under platinum treatment in which the druggable kinase SGK2 plays a central role. Our data suggest that blocking autophagy via SGK2 inhibition could represent a novel therapeutic strategy to improve patients’ response to platinum.
A structured open dataset of government interventions in response to COVID-19
Authors: Desvars-Larrive Amélie , Dervic Elma , Haug Nina , Niederkrotenthaler Thomas , Chen Jiaying , Di Natale Anna , Lasser Jana , Gliga Diana S. , Roux Alexandra , Sorger Johannes , Chakraborty Abhijit , Ten Alexandr , Dervic Alija , Pacheco Andrea , Jurczak Ania , Cserjan David , Lederhilger Diana , Bulska Dominika , Berishaj Dorontinë , Tames Erwin Flores , Álvarez Francisco S. , Takriti Huda , Korbel Jan , Reddish Jenny , Grzymała-Moszczyńska Joanna , Stangl Johannes , Hadziavdic Lamija , Stoeger Laura , Gooriah Leana , Geyrhofer Lukas , Ferreira Marcia R. , Bartoszek Marta , Vierlinger Rainer , Holder Samantha , Haberfellner Simon , Ahne Verena , Reisch Viktoria , Servedio Vito D. P. , Chen Xiao , Pocasangre-Orellana Xochilt María , Garncarek Zuzanna , Garcia David , Thurner Stefan 
Published: August 2020

AbstractIn response to the COVID-19 pandemic, governments have implemented a wide range of non-pharmaceutical interventions (NPIs). Monitoring and documenting government strategies during the COVID-19 crisis is crucial to understand the progression of the epidemic. Following a content analysis strategy of existing public information sources, we developed a specific hierarchical coding scheme for NPIs. We generated a comprehensive structured dataset of government interventions and their respective timelines of implementation. To improve transparency and motivate collaborative validation process, information sources are shared via an open library. We also provide codes that enable users to visualise the dataset. Standardization and structure of the dataset facilitate inter-country comparison and the assessment of the impacts of different NPI categories on the epidemic parameters, population health indicators, the economy, and human rights, among others. This dataset provides an in-depth insight of the government strategies and can be a valuable tool for developing relevant preparedness plans for pandemic. We intend to further develop and update this dataset until the end of December 2020.
Chia, a large annotated corpus of clinical trial eligibility criteria
Authors: Kury Fabrício , Butler Alex , Yuan Chi , Fu Li-heng , Sun Yingcheng , Liu Hao , Sim Ida , Carini Simona , Weng Chunhua 
Published: August 2020

AbstractWe present Chia, a novel, large annotated corpus of patient eligibility criteria extracted from 1,000 interventional, Phase IV clinical trials registered in ClinicalTrials.gov. This dataset includes 12,409 annotated eligibility criteria, represented by 41,487 distinctive entities of 15 entity types and 25,017 relationships of 12 relationship types. Each criterion is represented as a directed acyclic graph, which can be easily transformed into Boolean logic to form a database query. Chia can serve as a shared benchmark to develop and test future machine learning, rule-based, or hybrid methods for information extraction from free-text clinical trial eligibility criteria.
Challenges for the evaluation of digital health solutions—A call for innovative evidence generation approaches
Authors: Guo Chaohui , Ashrafian Hutan , Ghafur Saira , Fontana Gianluca , Gardner Clarissa , Prime Matthew 
Published: August 2020

AbstractThe field of digital health, and its meaning, has evolved rapidly over the last 20 years. For this article we followed the most recent definition provided by FDA in 2020. Emerging solutions offers tremendous potential to positively transform the healthcare sector. Despite the growing number of applications, however, the evolution of methodologies to perform timely, cost-effective and robust evaluations have not kept pace. It remains an industry-wide challenge to provide credible evidence, therefore, hindering wider adoption. Conventional methodologies, such as clinical trials, have seldom been applied and more pragmatic approaches are needed. In response, several academic centers such as researchers from the Institute of Global Health Innovation at Imperial College London have initiated a digital health clinical simulation test bed to explore new approaches for evidence gathering relevant to solution type and maturity. The aim of this article is to: (1) Review current research approaches and discuss their limitations; (2) Discuss challenges faced by different stakeholders in undertaking evaluations; and (3) Call for new approaches to facilitate the safe and responsible growth of the digital health sector.
Cultural Awareness of Students in Communication Sciences and Disorders: A Mixed-Methods Study
Authors: Domsch Celeste , Stiritz Lori , Huff Jay 
Published: August 2020

Purpose
This study used a mixed-methods design to assess changes in students' cultural awareness during and following a short-term study abroad.

Method

Thirty-six undergraduate and graduate students participated in a 2-week study abroad to England during the summers of 2016 and 2017. Quantitative data were collected using standardized self-report measures administered prior to departure and after returning to the United States and were analyzed using paired-samples
t
tests. Qualitative data were collected in the form of daily journal reflections during the trip and interviews after returning to the United States and analyzed using phenomenological methods.

Results

No statistically significant changes were evident on any standardized self-report measures once corrections for multiple
t
tests were applied. In addition, a ceiling effect was found on one measure. On the qualitative measures, themes from student transcripts included increased global awareness and a sense of personal growth.

Conclusions
Measuring cultural awareness poses many challenges. One is that social desirability bias may influence responses. A second is that current measures of cultural competence may exhibit ceiling or floor effects. Analysis of qualitative data may be more useful in examining effects of participation in a short-term study abroad, which appears to result in decreased ethnocentrism and increased global awareness in communication sciences and disorders students. Future work may wish to consider the long-term effects of participation in a study abroad for emerging professionals in the field.
Monitoring of the evolution of H2O vapor in the stratosphere of Jupiter over an 18-yr period with the Odin space telescope
Authors:   The Odin Team, Benmahi B. , Cavalié T. , Dobrijevic M. , Biver N. , Bermudez-Diaz K. , Sandqvist Aa. , Lellouch E. , Moreno R. , Fouchet T. , Hue V. , Hartogh P. , Billebaud F. , Lecacheux A. , Hjalmarson Å. , Frisk U. , Olberg M. 
Published: August 2020

Context. The comet Shoemaker-Levy 9 impacted Jupiter in July 1994, leaving its stratosphere with several new species, with water vapor (H2O) among them.
Aims. With the aid of a photochemical model, H2O can be used as a dynamical tracer in the Jovian stratosphere. In this paper, we aim to constrain the vertical eddy diffusion (Kzz) at levels where H2O is present.
Methods. We monitored the H2O disk-averaged emission at 556.936 GHz with the space telescope between 2002 and 2019, covering nearly two decades. We analyzed the data with a combination of 1D photochemical and radiative transfer models to constrain the vertical eddy diffusion in the stratosphere of Jupiter. Results. Odin observations show us that the emission of H2O has an almost linear decrease of about 40% between 2002 and 2019. We can only reproduce our time series if we increase the magnitude of Kzz in the pressure range where H2O diffuses downward from 2002 to 2019, that is, from ~0.2 mbar to ~5 mbar. However, this modified Kzz is incompatible with hydrocarbon observations. We find that even if an allowance is made for the initially large abundances of H2O and CO at the impact latitudes, the photochemical conversion of H2O to CO2 is not sufficient to explain the progressive decline of the H2O line emission, which is suggestive of additional loss mechanisms.
Conclusions. The Kzz we derived from the Odin observations of H2O can only be viewed as an upper limit in the ~0.2 mbar to ~5 mbar pressure range. The incompatibility between the interpretations made from H2O and hydrocarbon observations probably results from 1D modeling limitations. Meridional variability of H2O, most probably at auroral latitudes, would need to be assessed and compared with that of hydrocarbons to quantify the role of auroral chemistry in the temporal evolution of the H2O abundance since the SL9 impacts. Modeling the temporal evolution of SL9 species with a 2D model would naturally be the next step in this area of study.
Verbesserung der Arzneimitteltherapiesicherheit durch ein
klinikinternes Meldesystem – Analyse der Meldungen über 15 Jahre
einer Kinderklinik
Authors: Toni Irmgard , Neubert Antje , Rascher Wolfgang 
Published: August 2020

Zusammenfassung
Hintergrund Die Patientensicherheit ist eine große
Herausforderung und hat hohe Priorität in der stationären
Behandlung von Patienten. Neben chirurgischen Eingriffen gilt v. a. die
Arzneimitteltherapie als kritisch. Dabei ist der Medikationsprozess bei
Neugeborenen und Kindern besonders diffizil und problematisch.
Methode In einer retrospektiven Analyse wurden klinikinterne
Spontanberichte zu Arzneimitteltherapiebezogenen Problemen (ATBP) einer Kinder-
und Jugendklinik analysiert, die in den Jahren 2000–2014 gemeldet
wurden.
Ergebnisse 229 Spontanmeldungen zu ATBP wurden für die Analyse
berücksichtigt. 72,5% dieser erfolgten aufgrund eines
Medikationsfehlers. Knapp die Hälfte der ATBP ereignete sich
während der Abgabe von Arzneimitteln (44,5%), gefolgt von
Problemen bei der Anwendung (38,0%) und der Verordnung (11,4%).
Medikationsfehler waren zu 61,4% Abgabefehler (v. a.
Verwechslung von Patienten, fehlerhafte Dosis), sonstige Ereignisse wurden
nahezu vollständig der Arzneimittelanwendung zugeordnet (v. a.
Paravasate). 40,6% der ATBP waren mit einem klinisch relevanten
Patientenschaden verbunden und traten primär während der
Arzneimittelanwendung auf.
Schlussfolgerung Die Ergebnisse zeigen, dass die Arzneimitteltherapie in
der Pädiatrie ein komplexer und riskanter Prozess ist. Das System der
klinikinternen Spontanmeldungen führte zu regelmäßigen
Schulungen und zur Sensibilisierung der Mitarbeiter für kritische
Situationen. Zudem fördert es eine Kultur der Sicherheit, Fehler offen
zu berichten. Spontanmeldungen sind geeignet die Arzneimitteltherapie in der
Pädiatrie sicherer zu machen.
A case of primary adenocarcinoma of the seminal vesicle treated by total laparoscopic pelvic exenteration
Authors: Tochigi Kosuke , Matsukawa Yoshihisa , Ishida Shohei , Funahashi Yasuhito , Fujita Takashi , Kato Masashi , Gotoh Momokazu 
Published: August 2020

AbstractAn adenocarcinoma of the seminal vesicle is a rare malignancy with a poor prognosis. Its symptoms are non-specific, rendering diagnosis difficult. We present the case of a 74-year-old male with haematospermia. Magnetic resonance imaging revealed a bulky tumour of the seminal vesicle infiltrating the prostate gland, bladder and rectum. A transrectal ultrasound-guided biopsy revealed an adenocarcinoma. Computed tomography revealed multiple lung metastases. The serum CA-125 level was high. Androgen deprivation therapy and chemotherapy (docetaxel) were prescribed. After 12 courses of docetaxel, the primary tumour and the lung metastases decreased in size and the serum CA-125 level returned to normal. The patient underwent total laparoscopic pelvic exenteration with placement of a neobladder. Histological examination revealed a mucinous adenocarcinoma with negative surgical margins. The patient did not receive adjuvant chemotherapy or radiation. He shows no evidence of recurrence 19 months after surgery.
Caffeine Supplementation or Carbohydrate Mouth Rinse Improves Performance
Authors: Pereira Paulo Eduardo Assis , Azevedo Paulo , Azevedo Katia , Azevedo Warleyson , Machado Marco 
Published: August 2020

AbstractTraining volume is one of the critical variables required to promote resistance training benefits (e. g., hypertrophy, muscular strength). Thus, strategies to improve training volume are required. We tested the hypothesis that there is an increase in performance and reduction in the rate of perceived exertion in strength training with caffeine supplementation, carbohydrate mouth rinse, and a synergistic effect of caffeine supplementation plus carbohydrate mouth rinse. We recruited 29 physically active women: 24±4 years, 60.0±7.9 kg, 161.0±6.0 cm. This study was a double-blind, randomized, placebo-controlled, and crossover one. The subjects performed all sessions of strength training under different conditions: caffeine (6.5 mg·kg−1 body mass); carbohydrate (6 g of maltodextrin rinsed for 10 s); caffeine plus carbohydrate; or placebo. We applied the ANOVA for repeated measures through the null-hypothesis statistical test, and the Bayes factors analyses approach. The subjects showed significant improvement in the total repetitions (P<0.01; BF10 ~99%) for both lower and upper limb exercises in all conditions compared to placebo without difference among interventions. The rate of perceived exertion (P>0.05) did not differ among interventions. However, BF10 analyses showed a higher probability of lower RPE for CAF intervention. We conclude that either caffeine supplementation or carbohydrate mouth rinse can improve performance in resistance training. There is no additional effect of caffeine plus carbohydrate.
Changes in Lung Diffusing Capacity of Elite Artistic Swimmers During
Training
Authors: García Iker , Drobnic Franchek , Pons Victoria , Viscor Ginés 
Published: August 2020

AbstractArtistic swimmers (AS) are exposed to repeated apnoeas in the aquatic environment
during high intensity exercise provoking specific physiological responses to
training, apnoea, and immersion. This study aimed to evaluate the changes in
lung diffusing capacity in AS pre-, mid- and post-training in a combined session
of apnoeic swimming, figures and choreography. Eleven elite female AS from the
Spanish national team were the study’s participants. The single-breath
method was used to measure lung diffusing capacity for carbon monoxide
(DLCO) and one-way repeated measures ANOVA was utilized to
evaluate the statistical analysis. Basal values of DLCO were higher
than normal for their age and height
(33.6±4.9 mL·min−1·mmHg−1;
139±19%) and there were a significant interaction between
DLCO and AS training (ŋ2
p=0.547). After the apnoeic swimming (mid-training) there was
an increase in DLCO from basal to
36.7±7.3 mL·min−1·mmHg−1
(p=0.021), and after the figures and choreography (post-training) there
was a decrease compared to mid-training
(32.3±4.6 mL·min−1·mmHg−1,
p=0.013). Lung diffusing capacity changes occur during AS training,
including a large increase after apnoeic swimming. There were no differences in
lung diffusing capacity from pre- to post-training, although large
inter-individual variability was observed.
Mythri 1.0—Progress of an Indian Surgical Robot
Authors: V. Vikas , Voggu Aravind Reddy , Arumalla Kirit , Doshi Ronak , Ramkumar Aravind , Mahadevan Anita , Rao Madhav 
Published: August 2020

AbstractNeurosurgical procedures are performed using operating microscopes. The technology of most microscopes has not changed much over the past 60 years. The National Institute of Mental Health and Neurosciences and International Institute of Information Technology based at Bengaluru have embarked on joint collaboration for developing robot for neurosurgical applications. As a working prototype, robotic microscope Mythri 1.0 has been developed. An overview of the development process, working, and features of the device is presented in the article.
Nasal High Frequency Oscillatory Ventilation for Respiratory Failure due to Respiratory Syncytial Virus Bronchiolitis: Case Report
Authors: Liberatore Pio , Maffei Gianfranco 
Published: August 2020

AbstractThe authors describe a case of acute respiratory failure due to severe bronchiolitis. During high-flow nasal cannula ventilation, the blood's high levels of hypercapnia had taken them to plan the sedation and the orotracheal intubation. However, before attempting intubation, a nasal high frequency oscillatory ventilation cycle was performed and it led to a marked improvement in the blood gas, avoiding in this way the invasive ventilation.
Imaging Postoperative Abdominal Hernias: A Review with a Clinical Perspective
Authors: Chatterjee Argha , Ramanan Rochita V. , Mukhopadhyay Sumit 
Published: August 2020

AbstractPostoperative internal hernia is a challenging but critical diagnosis in postoperative patients presenting with acute abdomen. Postoperative internal hernias are increasingly being recognized after Roux-en-Y gastric bypass (RYGB) and bariatric surgeries. These internal hernias have a high risk of closed-loop obstruction and bowel ischemia; therefore, prompt recognition is necessary. Computed tomography (CT) is the imaging modality of choice in cases of postoperative acute abdomen. Understanding the types of postoperative internal hernia and their common imaging features on CT is crucial for the abdominal radiologist. Postoperative external hernias are usually a result of defect or weakness of the abdominal wall created because of the surgery. CT helps in the detection, delineation, diagnosis of complications, and surgical planning of an external hernia. In this article, the anatomy, pathophysiology, and CT features of common postoperative hernias are discussed. Afterreading this review, the readers should be able to (1) enumerate the common postoperative internal and external abdominal hernias, (2) explain the pathophysiology and surgical anatomy of Roux-en-Y gastric bypass-related hernia, (3) identify the common imaging features of postoperative hernia, and (4) diagnose the complications of postoperative hernias.
The cochlear outer hair cell speed paradox
Authors: Rabbitt Richard D. 
Published: August 2020

SignificanceMammalian hearing requires outer hair cells for amplification and tuning in the cochlea. The amplification process works at frequencies at least 10 times higher than might be expected based on electrical properties of the cells. The present report demonstrates how protein-dependent membrane piezoelectricity underlies high-frequency function, and why power output is maximum at frequencies much higher than would be predicted based on traditional experimental measurements. The interplay between electrical charge displacement and mechanical strain in the membrane motor is key. The same biophysical principles identify the origins of infrared laser-induced capacitive currents reported previously in hair cells, HEK cells, and neurons.
Nonholomorphic Ramanujan-type congruences for Hurwitz class numbers
Authors: Beckwith Olivia , Raum Martin , Richter Olav K. 
Published: August 2020

SignificanceHurwitz class numbers were introduced over 100 y ago, and they impact different areas of mathematics. In particular, their generating function is a so-called mock modular form. Despite their importance, essentially nothing has been known about the divisibility properties of Hurwitz class numbers on arithmetic progressions. Our work provides results on such divisibility properties, which differ drastically from known divisibility results for coefficients of other mock modular forms.
Novel parasite invasion leads to rapid demographic compensation and recovery in an experimental population of guppies
Authors: Rogowski Emma L.B. , Van Alst Andy D. , Travis Joseph , Reznick David N. , Coulson Tim , Bassar Ronald D. 
Published: August 2020

Significance
Does increased mortality from novel predators or parasites always lead to decreased prey or host population sizes? Theory says no, but we have too few examples of such compensatory effects to answer this question conclusively. We address this gap using long-term data from populations recently invaded by a nematode parasite. We combine analyses of the subsequent changes in population dynamics with comparable data from an uninfected population and laboratory assays of the effect of the parasite on fitness components. Our results show that the negative effect of the novel parasite was short-lived. The host population quickly recovered, even while experiencing high levels of parasite prevalence (72%). Host recovery was a consequence of increased survival and a density-dependent increase in recruitment.
POPOVICH, encoding a C2H2 zinc-finger transcription factor, plays a central role in the development of a key innovation, floral nectar spurs, inAquilegia
Authors: Ballerini Evangeline S. , Min Ya , Edwards Molly B. , Kramer Elena M. , Hodges Scott A. 
Published: August 2020

SignificanceThroughout evolutionary history, organisms have evolved features that allow them to interact with their environment in novel ways. When such features lead to increased rates of speciation in a lineage, we call them key innovations. Understanding the genetic and developmental changes involved in the origin of key innovations is of particular interest. Here we identify a gene,POPOVICH, that is crucial to the development of a key innovation, floral nectar spurs, in the columbine genusAquilegia. While the function ofPOPOVICHorthologs in other plant taxa suggests an ancestral function of the lineage in leaf development, inAquilegia,POPOVICHalso functions to promote cell division in petals, a key cellular step in the development of nectar spurs in the genus.