bluuebunny/crossref_metadata_2025_split huggingface dataset:
A model for evaluating the vital factors affecting cloud computing adoption
Authors: Jianwen Cheng , Wakil Karzan 
Published: November 2019

Purpose
Nowadays, the rapid growth of information technology strategies such as cloud computing is very noticeable in organizations. The advantages of the cloud environment are unavoidable because of an increase in innovation, flexibility and economy. Therefore, the critical topic is considering the factors affecting the adoption of cloud computing. This study aims to understand the factors of the adoption of cloud computing and its benefit in companies.

Design/methodology/approach
A research framework with four hypotheses has been developed based on the results of previous studies. Structural equation modeling has been used for data analysis.

Findings
The proposed model is verified by the results. In addition, the results have shown that cloud computing adoption is affected by four variables as follows, including human factor (with sub-indicator personal innovativeness and knowledge), organizational factor (with sub-indicator size, adequacy of resources and top management support), technical factor (with sub-indicator compatibility and security) and environmental factor (with sub-indicator regulatory environment, competitive pressure and trading partner).

Research limitations/implications
There are crucial implications in the findings: they have an essential contribution to the research community, administrators and Information and Communications Technology providers with respect to framing improved tactics for the adoption of cloud computing. The proposed model can enhance the perception of service providers about why some services sectors accept cloud computing amenities, whereas apparently the same ones having the same market situations do not. In addition, the above providers should enhance their interaction with the services sectors contributed to the cloud computing experience to make a well-organized setting for the adoption of cloud computing, and eliminate any ambiguity about this sort of technology. Moreover, the sample has been limited to Iran respondents.

Practical implications
The research studies about the usage of cloud computing have shown its effects on organizations today. Also, the different impacts of cloud computing on other contexts and organizations are in the center of attention. By carefully considering and managing cloud computing adoption logics, organizations could get significant advantages.

Originality/value
Cloud computing’s technical and operational issues have been central in most of the previous studies. Some surveys have referred to the adoption of cloud computing by the organizations in terms of human characteristics or the contextual factor. Therefore, there should be a model and outline to assess the effect of aforesaid factors on cloud computing adoption.
Mapping near surface global marine ecosystems through cluster analysis of environmental data
Authors: Zhao Qianshuo , Basher Zeenatul , Costello Mark J. 
Published: November 2019

AbstractAlmost all classifications of the world ocean are based on expert opinion or ad hoc management areas. A quantitative analysis of environmental variables may provide a more objective basis for mapping and classifying the oceans to support data management, reporting, and conservation efforts. Here, we used long‐term averages of 20 ocean variables to classify the ocean surface waters using PCA and k‐means clustering. We identified seven distinct areas that fit the definition of “ecosystems,” that is, enduring regions demarcated by environmental characteristics. Of all the variables, temperature had the greatest importance and correlated with many other variables. However, some variables had uniquely significant effects on the classification, namely slope, surface current, pH, and wave height. Thus, while the present classification is robust for available data, future analyses with variables not presently available may improve it. How the ecosystems correlate with species richness, endemicity, or abundance will inform on the factors that most influence species' abundance, and thus support global modeling of the effects of climate change, for example, with regard to biological carbon fluxes.
A specific group of patients with diagnostic conversion from depression to bipolar disorder and finally to dementia as a mental GSK‐3 disease: A hypothesis
Authors: Terao Takeshi , Ishii Nobuyoshi , Hirakawa Hirofumi 
Published: November 2019

AbstractObjectivesTo focus on a specific group of patients whose diagnoses were changed from unipolar depression to bipolar disorder, and finally to dementia.MethodsQualitative review of the relevant articles.ResultsA substantial portion of patients with unipolar depression manifest manic and/or hypomanic episodes, resulting in a change of diagnoses to bipolar disorder. Further, a substantial portion of bipolar patients develop dementia. Previous research suggests that genetic variants in the glycogen synthase kinase 3β (GSK‐3β) gene are associated with early onset of unipolar depression, a subset of which may be bipolar depression, with three SNPs (rs334555, rs119258668, and rs11927974) identified. Notably, another promotor SNP (rs334558) of the GSK‐3β gene is reportedly associated with unipolar depression, bipolar disorders, and dementia. Additionally, lithium, which is reported to inhibit GSK‐3, is generally accepted to be effective for bipolar disorder and recently reported to be effective for dementia.ConclusionsThere is a specific group of patients whose diagnoses longitudinally change from depression to bipolar disorder and finally to dementia, and GSK‐3 may be a common etiological factor in these diseases and in diagnostic conversions.
Antitumor activity of cyclin‐dependent kinase inhibitor alsterpaullone in Epstein‐Barr virus‐associated lymphoproliferative disorders
Authors: Watanabe Takahiro , Sato Yoshitaka , Masud H. M. Abdullah Al , Takayama Masahiro , Matsuda Hiroki , Hara Yuya , Yanagi Yusuke , Yoshida Masahiro , Goshima Fumi , Murata Takayuki , Kimura Hiroshi 
Published: November 2019

AbstractEpstein‐Barr virus (EBV) is a well‐established tumor virus that has been implicated in a wide range of immunodeficiency‐associated lymphoproliferative disorders (LPDs). Although rituximab, a CD20 mAb, has proven effective against EBV‐associated LPDs, prolonged use of this drug could lead to resistance due to the selective expansion of CD20− cells. We have previously shown that cyclin‐dependent kinase (CDK) inhibitors are able to specifically suppress the expression of viral late genes, particularly those encoding structural proteins; however, the therapeutic effect of CDK inhibitors against EBV‐associated LPDs is not clear. In this study, we examined whether CDK inhibitors confer a therapeutic effect against LPDs in vivo. Treatment with alsterpaullone, an inhibitor of the CDK2 complex, resulted in a survival benefit and suppressed tumor invasion in a mouse model of LPDs. Inhibition of CDK efficiently induced G1 cell cycle arrest and apoptosis in EBV‐positive B cells. These results suggest that alsterpaullone suppresses cell cycle progression, resulting in the antitumor effect observed in vivo.
Diagnostic testing for Graves' or non‐Graves' hyperthyroidism: A comparison of two thyrotropin receptor antibody immunoassays with thyroid scintigraphy and ultrasonography
Authors: Scappaticcio Lorenzo , Trimboli Pierpaolo , Keller Franco , Imperiali Mauro , Piccardo Arnoldo , Giovanella Luca 
Published: November 2019

AbstractObjectiveGraves' disease (GD) is the most common cause of hyperthyroidism. In many cases, when the aetiological diagnosis of GD is not evident based on the clinical evaluation and thyroid function testing, it may become challenging to distinguish Graves' hyperthyroidism from other forms of thyrotoxicosis.The current study was primarly carried out to compare the diagnostic effectiveness of two TSH receptor antibody immunoassays (IMAs), ultrasonography and thyroid scintigraphy in hyperthyroidism scenario.MethodsWe retrospectively analysed consecutive patients with newly diagnosed and untreated thyrotoxicosis who underwent thyroid functional tests, both TRAb and TSI measurements, thyroid scintigraphy and ultrasonography. TRAb assessment was carried out by Kryptor® compact PLUS, while TSI by Immulite®. Echo pattern 3 corresponded to ‘thyroid inferno’, and the final diagnosis of GD vs non‐Graves' hyperthyroidism was made according to the thyroid scan (qualitative scintigraphy). Receiver operating characteristic (ROC) curves were drawn using the final diagnosis as reference. Clinical sensitivity and specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) were calculated for all the tests.ResultsA total of 124 untreated hyperthyroid patients were included in our study (GD, n = 86 vs non‐Graves' hyperthyroidism, n = 38). ROC curves showed that the optimal cut‐off values associated with the highest diagnostic sensitivity and specificity was 0.7 IU/L for TRAb Kryptor® (93 [85.4‐97.4] and 86.8 [71.9‐95.5]) and 0.1 IU/L for TSI Immulite® (94.2 [86.9‐98.1] and 84.2 [68.7‐93.9]), respectively. For the echo pattern 3, we found a good sensitivity (92.1%) and a high PPV (95.2%) but a quite low specificity value (69.8%) and a relative low NPV (57.5%). For thyroid scintigraphy, the TcTU cut‐off value of 1.3% corresponded to the best limit for sensitivity and specificity in our patients (95.3 [88.5‐98.7] and 96.4 [81.6‐99.4]). The Passing‐Bablok regression equation and the Bland‐Altman test showed a great degree of correlation and agreement existed between TRAb Kryptor® and Immulite® TSI results.ConclusionsThyroid scintigraphy remains the most accurate method to differentiate causes of thyrotoxicosis. However, TRAb assays can be alternatively adopted in this setting, limiting the use of thyroid scintigraphy (TcTU evaluation) to TRAb‐negative patients. Thyoid US is less accurate than both TRAb/TSI and thyroid scintigraphy, but the ‘thyroid inferno’ pattern provides a high PPV for GD.
Maxillary sinus floor elevation using hydroxyapatite nano particles vs tenting technique with simultaneous implant placement: A randomized clinical trial
Authors: Khaled Hossam , Atef Mohammed , Hakam Maha 
Published: November 2019

AbstractPurposeThe present study was conducted to evaluate the amount of bone height gain, density values, and implant stability after maxillary sinus floor elevation using graftless tenting technique or the use of Hydroxyapatite Nanoparticles bone substitute for augmentation with simultaneous implant placement.Materials and MethodsA total of 20 sinuses with a residual alveolar bone height ranging from 4‐6 mm were divided into two groups and underwent sinus augmentation using nano hydroxyapatite bone substitute material and the graftless tenting technique with simultaneous implant placement. Computed tomography CT scans and ISQ measurements were conducted to evaluate bone quality, quantity, and implant stability.ResultsRadiographic analysis revealed that the mean bone height gain of the nano group was (7.0 ± 0.8 mm) compared to (5.0 ± 1.5 mm) in the tent group, which was statistically significant (P = .002) being higher in the nano group. The mean bone density value of the nano group was (548 ± 25 HU) compared to (420 ± 23 HU) in the tent group, which was statistically significant (P < .001) being higher in the nano group. The mean ISQ value after 6 months in the nano group was (78 ± 5) compared to (77 ± 5) in the tent group, which was statistically nonsignificant (P = .901).ConclusionNano hydroxyapatite bone graft offered superior results in terms of the bone height gain and the relative bone density as compared to graftless tenting technique. However, both techniques showed accepted results regarding implant stability.
Double aortic arch with atretic left arch distal to the origin of left subclavian artery accompanied by dyspnea: A case report and literature review
Authors: He Xinjian , Zhao Ning , Chen Jiaoyang , Wei Jiuru , Cui Yun , Li Gaoyang 
Published: November 2019

AbstractDouble aortic arch with atretic left arch distal to the origin of left subclavian artery is a rare type of vascular ring, and it can be easily confused with the right aortic arch with mirror branching. We provided a rare case of a 10‐month‐old infant with dyspnea. Echocardiography showed a suspicious double aortic arch with atretic left arch distal to the origin of left subclavian artery, which was confirmed intra‐operatively. We summarize ultrasonic image characteristics of the disease and combine it with computed tomography angiography, bronchoscopy, and clinical symptoms in order to improve the detection rate and treatment strategy.
Prognostic significance of left ventricular end diastolic pressure using E/E' in patients with hypertrophic cardiomyopathy
Authors: Badran Hala Mahfouz , Soltan Ghada , Almeleigi Reda , Faheem Naglaa , Yacoub Magdi H. 
Published: November 2019

AbstractBackgroundLeft ventricular (LV) diastolic dysfunction is a prominent feature of hypertrophic cardiomyopathy (HCM). Prediction of LV filling pressure using the ratio between early diastolic transmitral flow and mitral annular velocity (E/e') had proved a good accuracy.Aim of this studyWe investigated the value of E/e' to predict cardiovascular (CV) mortality in patients with HCM.MethodsA total of 243 patients with HCM had E/e' measured in combination with clinical evaluation, conventional echocardiographic measurements, cardiopulmonary exercise evaluation, and Holter monitoring.ResultsDuring a mean follow‐up of (3.2 ± 1.2 years), 17 (7%) patients died. Non survivors had significantly higher SBP, DBP, left ventricular outflow tract obstruction (LVOTO) gradient, mitral E, and E/e', but lower e' of mitral annulus and more prevalent restrictive filling pattern. E/e' was directly correlated with age (r = .24, P < .005), left atrial volume index (r = .44, P < .0001), LVMI (r=0.23,P<.005), LVOT gradient (r = .43, P < .0001), NYHA class (r = .19, P < .006), pulmonary artery pressure (r = .24, P < .005), positive family history of HCM (r = .22, P < .005), and inversely related to peak systolic velocity (S) (r = .44, P < .0001). By multivariate analysis, only LVOTO ([RR] 4.11, 95% CI 1.002 to 1.148, P < .04) and E/e' were independent predictors for overall mortality in HCM (relative risk [RR] 5.27, 95% CI 1.002 to 1.024, P < .02). The risk of dying increased with increasing E/e' ratio, being approximately 4 times higher for patients in the highest quartile (HR 3.8 (CI 1.38‐5.12, log‐rank < 0.002)).ConclusionsIn hypertrophic cardiomyopathy, the E/e' ratio remains a powerful predictor of all‐cause mortality, particularly if it is associated with LVOT obstruction.
Trade signing in fast markets
Authors: Carrion Allen , Kolay Madhuparna 
Published: November 2019

AbstractThis study assesses the accuracy of trade signing algorithms in fast trading environments using NASDAQ and NYSE trade and quote data. Using data that contain true trade signs, we show that the Lee and Ready algorithm outperforms the tick rule and classifies trades at least as well as in earlier studies from slower trading environments, even in subsamples where the market is particularly fast. We conclude that trade signing remains viable in fast markets, and that the use of quote data continues to increase trade classification accuracy.
Temperature drives local contributions to beta diversity in mountain streams: Stochastic and deterministic processes
Authors: Wang Jianjun , Legendre Pierre , Soininen Janne , Yeh Chih‐Fu , Graham Emily , Stegen James , Casamayor Emilio O. , Zhou Jizhong , Shen Ji , Pan Feiyan 
Published: November 2019

AbstractAimCommunity variation (i.e. beta diversity) along geographical gradients is of substantial interest in ecology and biodiversity reserves in the face of global changes. However, the generality in beta diversity patterns and underlying processes remains less studied across trophic levels and geographical regions. We documented beta diversity patterns and underlying ecological processes of stream bacteria, diatoms and macroinvertebrates along six elevational gradients.LocationsAsia and Europe.MethodsWe examined stream communities using molecular and morphological methods. We characterised community uniqueness with local contributions to beta diversity (LCBD), and investigated the drivers of its geographic patterns using Mid‐Domain Effect (MDE), coenocline simulation, Raup‐Crick null model approach, and through comparisons to environmental factors. MDE is a stochastic model by considering species elevational range, while coenocline simulation is a deterministic model by considering species niche optima and tolerance. The null model provides possible underlying mechanisms of community assembly with the degree to which deterministic processes create communities deviating from those of null expectations.ResultsAcross all taxa, we revealed a general U‐shaped LCBD‐elevation relationship, suggesting higher uniqueness of community composition at both elevational ends. This pattern was confirmed and could be explained by both stochastic and deterministic models, that is, MDE and coenocline simulation, respectively, and was supported by the dominance of species replacement. Temperature was the main environmental factor underlying elevational patterns in LCBD. The generalists with broad niche breadths were key in maintaining community uniqueness, and the higher relative importance of deterministic processes resulted in stronger U‐shaped patterns regardless of taxonomic group.ConclusionsOur synthesis across both mountains and taxonomic groups clearly shows that there are consistent elevational patterns in LCBD among taxonomic groups, and that these patterns are explained by similar ecological mechanisms, producing a more complete picture for understanding and bridging the spatial variation in biodiversity under changing climate.
Bleeding assessment in haemophilia carriers—High rates of bleeding after surgical abortion and intrauterine device placement: A multicentre study in China
Authors: Li Sen , Fang Yunhai , Li Li , Lee Adrienne , Poon Man‐Chiu , Zhao Yongqiang , Zhang Xinsheng , Wang Shujie , Cheng Yan , Li Kuixing 
Published: November 2019

AbstractIntroductionAn increased bleeding tendency has been shown in female haemophilia carriers compared to healthy females. Bleeding assessment tools (BATs) have mainly been performed in western cultures. It is unclear how they perform in populations with different healthcare, health/wellness concepts and awareness, as well as family planning practices.AimTo (a) describe and compare the bleeding symptoms in carriers with healthy females, particularly for bleeding after surgical abortion and intrauterine device (IUD) placement which are performed frequently for family planning in China; (b) quantify scores of International Society on Thrombosis and Haemostasis Bleeding Assessment Tool (ISTH‐BAT) and Chinese‐BAT (C‐BAT) developed to include surgical abortion and IUD placement as separate categories in Chinese haemophilia carriers; (c) correlate bleeding scores (BS) with factor levels.MethodsWe conducted a multicentre, cross‐sectional study on obligate haemophilia carriers and healthy controls using ISTH‐BAT and C‐BAT.ResultsWe enrolled 125 haemophilia carriers and 106 controls. Carriers, compared to controls, had significantly higher median BS (3 vs 1 by both ISTH‐BAT and C‐BAT) and lower factor level (63.5 vs 101.8 IU/dL). Bleeding after surgical abortion and IUD placement was significantly associated with carrier status. Bleeding scores from neither ISTH‐BAT nor C‐BAT showed significant correlation with factor levels.ConclusionHaemophilia carriers in China experienced abnormal bleeding. Unique to the Chinese carriers is significant bleeding after surgical abortion (3rd highest incidence of bleeding symptom) and IUD placement (4th highest). However, both ISTH‐BAT and C‐BAT exhibited no correlation between BS and factor levels in this population and neither could identify carriers with low factor level (of <50 IU/dL).
Revealing the secret life of skin ‐ with the microbiome you never walk alone
Authors: Sfriso R. , Egert M. , Gempeler M. , Voegeli R. , Campiche R. 
Published: November 2019

AbstractThe human skin microbiome has recently become a focus for both the dermatological and cosmetic fields. Understanding the skin microbiota, that is the collection of vital microorganisms living on our skin, and how to maintain its delicate balance is an essential step to gain insight into the mechanisms responsible for healthy skin and its appearance. Imbalances in the skin microbiota composition (dysbiosis) are associated with several skin conditions, either pathological such as eczema, acne, allergies or dandruff or non‐pathological such as sensitive skin, irritated skin or dry skin. Therefore, the development of approaches which preserve or restore the natural, individual balance of the microbiota represents a novel target not only for dermatologists but also for skincare applications. This review gives an overview on the current knowledge on the skin microbiome, the currently available sampling and analysis techniques as well as a description of current approaches undertaken in the skincare segment to help restoring and balancing the structure and functionality of the skin microbiota.
Determining the quality of life and the sleep quality in patients with benign prostate hyperplasia
Authors: Kulakaç Nurşen , Sayılan Aylin Aydın 
Published: November 2019

AbstractResearch questionHow is the quality of life and quality of sleep affected in patients with benign prostatic hyperplasia?Research problemThe aim of this study was to evaluate the quality of life and quality of sleep in patients with benign prostatic hyperplasia (BPH) and to identify the relationship between them. Nocturia is one of the main symptoms associated to BPH, causing significant sleep disturbances, including sleep interruptions. Such sleep interruptions may significantly impair quality of life.Literature reviewThe assessment of nocturia and its impact on quality of life and sleep quality in patients living with benign prostatic hyperplasia (BPH) has been poor in terms of clinical research; moreover, there is a lack of specific methods to assess this impact.MethodologyThe sample of this descriptive study consisted of all patients with the diagnosis of BPH who were admitted to the urology outpatient clinic of a state hospital in Turkey. The data were collected from 212 patients with BPH who accepted to participate in the study in January‐June 2018. All patients gave consent prior to inclusion in the study. The Pittsburgh Sleep Quality Index and the WHOQOL‐BREF (World Health Organization Quality of Life Scale ‐ Brief Form) were used as the principle data collection tools. Percentage, t test, correlation and one‐way variance analysis test were used to evaluate the data.ResultsThe mean age of the patients was 67.50 ± 8.89 years and 63.2% of them were first diagnosed with benign prostatic hyperplasia 2.13 years ago. The lowest and the highest average scores that the patients obtained from the WHOQOL‐BREF were their social and environmental domains scores, respectively. In all, 20.2% of the patient were found to have poor sleep quality (global score ≥ 5). The results showed that there was a positive correlation between the mean scores of the sleep quality of the patients and their quality of life physical domain subscale. It was also found that there was a significant negative correlation between night urination and the sleep quality in BPH patients (P < .05).ConclusionsIt was determined that low quality of life in BPH patients is associated with low sleep quality. Personal characteristics, frequent night urination and working status are important determinants of the relationship between quality of life and sleep quality.