bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibacterial coatings on vegetable ivory obtained by cold plasma jet activation of silicone and copaiba oils
Authors: Ferreira da Silva Yuri , Queiroz Vanessa de M. , Kling Isabelle C. S. , Archanjo Braulio S. , Oliveira Renata N. , Simao Renata A. 
Published: May 2020

AbstractVegetable ivory obtained from the endosperm of jarina seeds (Phytelephas macrocarpa), native to the Amazon region, has been regarded as a sustainable alternative to elephant ivory; however, it is vulnerable to biodegradation due to its mannan polysaccharide composition. In this study, vegetable ivory was coated by atmospheric air plasma jet activation of silicone and copaiba oils. Stable, smooth, and crosslinked micrometric coatings were formed after 80 s of plasma activation. Water contact angle results show that hydrophobicity was enhanced without detrimental effects on the surface reflectance. The best antibacterial performance against Staphylococcus aureus and Escherichia coli was obtained for a 1:1 mixture of both oils due to the synergetic action of silicone hydrophobicity and copaiba bioactivity.
Common mechanism of thermostability in small α‐ and β‐proteins studied by molecular dynamics
Authors: Jana Kalyanashis , Mehra Rukmankesh , Dehury Budheswar , Blundell Tom L. , Kepp Kasper P. 
Published: May 2020

AbstractProtein thermostability is important to evolution, diseases, and industrial applications. Proteins use diverse molecular strategies to achieve stability at high temperature, yet reducing the entropy of unfolding seems required. We investigated five small α‐proteins and five β‐proteins with known, distinct structures and thermostability (Tm) using multi‐seed molecular dynamics simulations at 300, 350, and 400 K. The proteins displayed diverse changes in hydrogen bonding, solvent exposure, and secondary structure with no simple relationship to Tm. Our dynamics were in good agreement with experimental B‐factors at 300 K and insensitive to force‐field choice. Despite the very distinct structures, the native‐state (300 + 350 K) free‐energy landscapes (FELs) were significantly broader for the two most thermostable proteins and smallest for the three least stable proteins in both the α‐ and β‐group and with both force fields studied independently (tailed t‐test, 95% confidence level). Our results suggest that entropic ensembles stabilize proteins at high temperature due to reduced entropy of unfolding, viz., ΔG = ΔH − TΔS. Supporting this mechanism, the most thermostable proteins were also the least kinetically stable, consistent with broader FELs, typified by villin headpiece and confirmed by specific comparison to a mesophilic ortholog of Thermus thermophilus apo‐pyrophosphate phosphohydrolase. We propose that molecular strategies of protein thermostabilization, although diverse, tend to converge toward highest possible entropy in the native state consistent with the functional requirements. We speculate that this tendency may explain why many proteins are not optimally structured and why molten‐globule states resemble native proteins so much.
Effect of the measurement errors on two one‐sided Shewhart control charts for monitoring the ratio of two normal variables
Authors: Du Nguyen Huu , Phuc Tran Kim 
Published: May 2020

AbstractMonitoring the ratio between two random normal variables plays an important role in many industrial manufacturing processes. In this paper, we suggest designing two one‐sided Shewhart control charts monitoring this ratio. The numerical results show that the one‐sided charts have more advantages compared with the two‐sided Shewhart chart proposed previously in the literature. Moreover, we investigate the effect of measurement error on the performance of these control charts where the measurement error is supposed to follow a linear covariate error model. The change of model parameters from an in‐control condition to an out‐of‐control is presented without using a strict assumption about the independence of the shift size from measurement errors. A valuable finding from this study is that taking multiple measurements per item is not an effective way to reduce the negative effect of measurement error on the Shewhart charts' performance.
Adaptive P‐type iterative learning radial basis function control for robot manipulators with unknown varying disturbances and unknown input dead zone
Authors: Bensidhoum Tarek , Bouakrif Farah 
Published: May 2020

SummaryThis article proposes an adaptive iterative learning radial basis function (RBF) scheme to solve the trajectory‐tracking problem for perturbed robot manipulators with unknown iteration varying disturbances and unknown dead‐zone input. It is well known that the presence of the dead zone in actuators and mechatronics devices gives rise to extra difficulty due to the presence of singularity in the input channels. Hence, it is interesting to take this problem into account when synthesizing a controller. This synthesis is made here. In addition, the control design is very simple in the sense that we use, only, the proportional gain. Therefore, the considerable amount noise caused by the sensors for velocity measurements of robot manipulators is avoided. Another advantage of this work is that the unknown disturbances are assumed to be time varying and also varying from iteration to iteration. Thus, the RBF neural network is used to approximate these unknown nonlinear functions. Using the Lyapunov theory, the analysis of the stability of the closed‐loop system is guaranteed when the iteration number tends to infinity. Finally, simulation results on the PUMA 560 arm are provided to illustrate the effectiveness of the proposed method. In order to evaluate the performance of our controller, a comparison of our results with other method is also given.
A tractable method to account for high‐dimensional nonignorable missing data in intensive longitudinal data
Authors: Yuan Chengbo , Hedeker Donald , Mermelstein Robin , Xie Hui 
Published: May 2020

AbstractDespite the need for sensitivity analysis to nonignorable missingness in intensive longitudinal data (ILD), such analysis is greatly hindered by novel ILD features, such as large data volume and complex nonmonotonic missing‐data patterns. Likelihood of alternative models permitting nonignorable missingness often involves very high‐dimensional integrals, causingcurse of dimensionalityand rendering solutions computationally prohibitive to obtain. We aim to overcome this challenge by developing a computationally feasible method, nonlinear indexes of local sensitivity to nonignorability (NISNI). We use linear mixed effects models for the incomplete outcome and covariates. We use Markov multinomial models to describe complex missing‐data patterns and mechanisms in ILD, thereby permitting missingness probabilities to depend directly on missing data. Using a second‐order Taylor series to approximate likelihood under nonignorability, we develop formulas and closed‐form expressions for NISNI. Our approach permits the outcome and covariates to be missing simultaneously, as is often the case in ILD, and can capture U‐shaped impact of nonignorability in the neighborhood of the missing at random model without fitting alternative models or evaluating integrals. We evaluate performance of this method using simulated data and real ILD collected by the ecological momentary assessment method.
Relationships among adverse childhood experiences, posttraumatic stress disorder symptom clusters, and health in women veterans
Authors: Wooldridge Jennalee S. , Bosch Jeane , Crawford Jennifer N. , Morland Leslie , Afari Niloofar 
Published: May 2020

AbstractAdverse childhood experiences (ACEs) increase risk for negative health outcomes. The goal of this study was to examine the relationships among cumulative ACEs, ACEs type, posttraumatic stress disorder (PTSD) symptoms, PTSD symptom clusters, and physical health symptoms in a sample of women veterans (N = 76). Bivariate correlations were used to determine which ACE domains were associated with PTSD and physical health symptoms. Follow‐up linear regressions indicated cumulative ACEs were significantly associated with total PTSD symptoms. Cumulative ACEs were also significantly associated with the avoidance and hyperarousal symptom clusters, but not the re‐experiencing symptom cluster. Total PTSD symptoms were significantly related to physical health symptoms. Of the three symptom clusters, only hyperarousal was significantly associated with physical health symptoms. Cross‐sectional mediation analyses indicated the total and direct effects of ACEs on physical health were not significant. However, the indirect effect through PTSD was significant (b = 0.46, [95% CI: 0.02, 0.91]), as well as through the avoidance (b = 0.47, [95% CI: 0.06, 0.90]), and hyperarousal symptom clusters (b = 0.56, [95% CI: 0.11, 1.04]). This study highlights the potential impact of ACEs on PTSD symptoms and physical health and suggests that hyperarousal symptoms of PTSD, may play a potential role in the development of physical health problems.
Experimental study on seismic performance of steel‐reinforced recycled concrete frame with infill wall
Authors: Liu Zuqiang , Xue Jianyang , Qi Liangjie , Gao Liang 
Published: May 2020

SummaryIn order to investigate the seismic performance of steel‐reinforced recycled concrete (SRRC) frame with infill wall, low cyclic loading tests on four frames with infill wall and one frame without infill wall were conducted. The failure modes, hysteresis loops, skeleton curves, bearing capacity, ductility, stiffness degradation, and energy dissipation capacity of specimens were analyzed. The seismic performance of SRRC frames with and without infill wall was compared. The influence of the aspect ratio of infill wall, the axial compression ratio of column, and the distance of horizontal reinforcements of infill wall were investigated. Test results show that compared to the SRRC frame without infill wall, the SRRC frame with infill wall had higher bearing capacity and initial stiffness, but faster stiffness degradation and worse energy dissipation capacity. With the increase of aspect ratio of infill wall and axial compression ratio of column, the bearing capacity and initial stiffness of SRRC frame with infill wall increased, whereas the ductility decreased. With the decrease of distance of horizontal reinforcements of infill wall, the initial stiffness and energy dissipation capacity of SRRC frame with infill wall increased. After the infill wall fails under earthquake, the remaining SRRC frame has good seismic performance.
Hierarchical multilabel classifier for gene ontology annotation using multihead and multiend deep CNN model
Authors: Yuan Xin , Pang Erli , Lin Kui , Hu Jinglu 
Published: May 2020

AbstractGene ontology annotation is known to be a very complicated multilabel classification task, and the hierarchical multilabel classification (HMC) approaches with local classifiers have been shown to be effective for the task. In a traditional HMC method, a set of hierarchically organized simple local classifiers are usually used, each of which for one hierarchical level separately. In this paper, we propose a novel hierarchical multilabel classifier implementing the whole set of hierarchically organized local classifiers in one deep convolution neural network (CNN) model with multiple heads and multiple ends (MHME). The proposed MHME CNN model consists of three parts: the body part of a deep CNN model shared by different local classifiers for feature extraction and feature mapping; the multiend part of a set of autoencoders performing feature fusion transforming the input vectors of different local classifiers to feature vectors with the same length so as to share the feature mapping part; and the multihead part of a set of linear multilabel classifiers. Furthermore, a sophisticated recursive algorithm is designed to train the MHME CNN model to realize the functions of a set of hierarchically organized local classifiers. In this way, by sharing a deep CNN with multiple local classifiers, we are able to construct more powerful local classifiers for each level with limited training samples, and to achieve better classification performance. Experiment results on various benchmark datasets show that the proposed deep CNN‐based model has better performance than the state‐of‐the‐art traditional models. Moreover, it gives rather good performance even under a transfer learning. © 2020 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
Oxygen transfer and plant‐wide energy assessment of primary screening in WRRFs
Authors: Pasini Federico , Garrido‐Baserba Manel , Ahmed Ahmed , Nakhla George , Santoro Domenico , Rosso Diego 
Published: May 2020

AbstractPrimary screening is gaining interest as a method to achieve removal performances comparable to primary clarification while reducing the footprint and increasing operational elasticity. Aeration efficiency indicators in a pilot sequential batch reactor (SBR) and a full scale water resource recovery facility (WRRF) were investigated after the implementation of rotating belt filters/screens (RBF). To compare the impact between screened (350 μm) and nonscreened primary influent, two identical treatment lines were monitored using off‐gas and respirometric measurements. The study provides the first result on improved oxygen transfer efficiency due to primary screening. Consistent aeration efficiency improvements of 27% and 20% between screened and nonscreened were obtained at pilot and full scale, respectively. Changes in aeration efficiency and carbon redirection were integrated into a set of models to investigate the primary screening impact on the WRRF energy balance. While the plant‐wide assessment for different scenarios improved the energy balance up to 15%, a detailed comparative analysis between various treatment schemes gained insight into the advantages and limitations of the energetic sustainability of primary screening.Practitioner points

Aeration efficiency improved 27% at pilot scale

Aeration efficiency improved 20% at full scale.

Use of primary screening can improve the energy balance up to 15

Assessment of advantages and limitations of primary screening.
Can information and trust about organic food improve consumer's attitude toward buying in Thailand?
Authors: Sriyakul Thanaporn , Sutduean Chutipan , Sirivanh Thongvanh 
Published: May 2020

AbstractThailand is gradually becoming an attractive market for organic food as tourists from different parts of the world try to experience unique food items. However, the attitude of local consumers toward buying organic food is not encouraging. Lack of information and trust on organic food procedures are probably the main factors influencing the local consumers. In this article, the role of information need, information seeking, and consumer’s trust on attitude toward buying organic food were studied. Moreover, this study also checked the moderating role of price barrier in given relationships which was not previously discussed in literature. Data, collected from 292 tourists and residents in Thailand through questionnaire and responses, were analyzed using confirmatory factor analysis and structural equation modeling. Results highlighted that all the three independent variables, information need, information seeking, and consumer’s trust, have significant impact on attitude toward buying organic food. Price barrier only proved as a significant moderator in the relationship between information need and consumer’s attitude toward buying organic food while it proved insignificant in other two relationships. This study also includes implications in industry, consumers, academia, and future research indications.
BPS states for scalar field theories based on $$ \mathfrak{g} $$2 and $$ \mathfrak{su} $$(4) algebras
Authors: Luchini G. , Tassis T. 
Published: May 2020

AbstractWe discuss two models in 1 + 1 dimensional space-time for real scalar field multiplets on the root space of $$ \mathfrak{g} $$
g
2 and $$ \mathfrak{su} $$
su
(4) Lie algebras. The construction of these models is presented and the corresponding BPS solutions are found.
Replica wormholes and the entropy of Hawking radiation
Authors: Almheiri Ahmed , Hartman Thomas , Maldacena Juan , Shaghoulian Edgar , Tajdini Amirhossein 
Published: May 2020

AbstractThe information paradox can be realized in anti-de Sitter spacetime joined to a Minkowski region. In this setting, we show that the large discrepancy between the von Neumann entropy as calculated by Hawking and the requirements of unitarity is fixed by including new saddles in the gravitational path integral. These saddles arise in the replica method as complexified wormholes connecting different copies of the black hole. As the replica number n → 1, the presence of these wormholes leads to the island rule for the computation of the fine-grained gravitational entropy. We discuss these replica wormholes explicitly in two-dimensional Jackiw-Teitelboim gravity coupled to matter.
The metalloproteinase ADAM10 requires its activity to sustain surface expression
Authors: Seifert Anke , Düsterhöft Stefan , Wozniak Justyna , Koo Chek Z. , Tomlinson Michael G. , Nuti Elisa , Rossello Armando , Cuffaro Doretta , Yildiz Daniela , Ludwig Andreas 
Published: May 2020

AbstractThe metalloproteinase ADAM10 critically contributes to development, inflammation, and cancer and can be controlled by endogenous or synthetic inhibitors. Here, we demonstrate for the first time that loss of proteolytic activity of ADAM10 by either inhibition or loss of function mutations induces removal of the protease from the cell surface and the whole cell. This process is temperature dependent, restricted to mature ADAM10, and associated with an increased internalization, lysosomal degradation, and release of mature ADAM10 in extracellular vesicles. Recovery from this depletion requires de novo synthesis. Functionally, this is reflected by loss and recovery of ADAM10 substrate shedding. Finally, ADAM10 inhibition in mice reduces systemic ADAM10 levels in different tissues. Thus, ADAM10 activity is critically required for its surface expression in vitro and in vivo. These findings are crucial for development of therapeutic ADAM10 inhibition strategies and may showcase a novel, physiologically relevant mechanism of protease removal due to activity loss.
The acid–base and redox properties of menaquinone MK-4, MK-7, and MK-9 (vitamin K2) in DMPC monolayers on mercury
Authors: Dharmaraj Karuppasamy , Román Silva Javier Ignacio , Kahlert Heike , Lendeckel Uwe , Scholz Fritz 
Published: May 2020

Abstract
The acid–base and redox properties of the menaquinones MK-4, MK-7, and MK-9 (vitamin K2) have been studied in DMPC monolayers on mercury electrodes. The monolayers were prepared by adhesion-spreading of menaquinone-spiked DMPC liposomes on a stationary mercury drop electrode. All three menaquinones possess $${\text{p}}K_{{\text{a}}}$$pKa constants outside the experimentally accessible range, i.e., they are higher than about 12. The standard potentials of MK-4, MK-7, and MK-9 in the DMPC monolayers are very similar, i.e., 0.351, 0.326, and 0.330 V (corresponding to the biochemical standard potentials − 0.063, − 0.088, and − 0.085 V).

Graphic abstract
Peroneus brevis as source of instability in Jones fracture fixation
Authors: Willegger Madeleine , Benca Emir , Hirtler Lena , Moser Lukas , Zandieh Shahin , Windhager Reinhard , Schuh Reinhard 
Published: May 2020

Abstract
Purpose
Intramedullary screw fixation is currently considered the gold standard treatment for Jones fractures in the athlete. Besides biological factors (i.e., poor vascularization), mechanical instability induced by the pull of the peroneus brevis tendon (PBT) contributes to deficient Jones fracture healing. This biomechanical study aimed to simulate loads induced by the PBT at the fifth metatarsal and to compare the stability of two intramedullary screw constructs in a Jones fracture fixation model.

Methods
Jones fractures were created in 24 human paired specimens, and fixation was achieved with either a solid Jones fracture specific screw (JFXS) (Jones Screw; Arthrex Inc., Naples FL, USA) or a cannulated headless compression screw (HCS) (HCS; DePuySynthes, Solothurn, Switzerland). The PBT was fixed to a mechanical load frame by the use of a cryoclamp. Constructs were loaded in tension for 1000 cycles, followed by an ultimate load test. Construct failure was defined by exceeding 10° of dorsal angulation.

Results
Preliminary failure occurred more often in HCS constructs (33%) compared to JFXS constructs (0%) (P = 0.044). Mean tensile load to failure reached 123.8 ± 91.4 N in the JFXS group and 91.5 ± 62.2 N in the HCS group (P = 0.337). The mean slope of the load-displacement curve was 24.2 ± 10.4 N/mm for JFXS constructs and 24.7 ± 5.5 N/mm for HCS constructs, respectively (P = 0.887).

Conclusion
This is the first study evaluating the effect of PBT pull on the mechanical stability of Jones fracture fixation. Higher preliminary failure rates of HCS were found under cyclic loading conditions compared to JFXS.
Plasma pentraxin 3 is higher in early ovarian hyperstimulation syndrome than in uncomplicated in vitro fertilization cycle of high-risk women
Authors: Korhonen Kati , Unkila-Kallio Leila , Alfthan Henrik , Hämäläinen Esa , Tiitinen Aila , Mikkola Tomi , Tapanainen Juha , Savolainen-Peltonen Hanna 
Published: May 2020

Abstract
Purpose
Pentraxin 3 (PTX3) is a locally secreted, quicker responsive pro-inflammatory protein than C-reactive protein (CRP). We evaluated the value of PTX3 in the prediction of ovarian hyperstimulation syndrome (OHSS), a severe complication of in vitro fertilization (IVF).

Methods
This two-year prospective follow-up study included 27 women with uncomplicated IVF-cycles (IVF group) and 31 patients diagnosed with moderate or severe early OHSS (OHSS group). PTX3 was analysed from follicular fluid (FF) and serial blood samples with enzyme-linked immunoassay and CRP with particle-enhanced immunoturbidimetric assay. The value of PTX3 and CRP in detecting OHSS was examined with receiver operating characteristic (ROC) curve analysis and expressed as the area under the curve (AUC).

Results
The circulating PTX3 level peaked at two days after oocyte pick-up (OPU2), and in the OHSS group the level was 1.9 times higher (P = 0.006) than in the IVF group. However, in ROC curve analysis PTX3 (AUC 0.79, best cut off 1.1 µg/L) was not superior to CRP (AUC 0.87; best cut off 9.5 mg/L) in predicting early OHSS. In the IVF group, the FF-PTX3 concentration was 15–20 times higher than in the plasma. PTX3 level at OPU2 correlated with the number of punctured follicles (r = 0.56, n = 22, P = 0.006). Triggering with human chorionic gonadotrophin or early pregnancy had no effect on PTX3 level.

Conclusion
The elevated PTX3 concentration in OHSS at OPU2, when freeze-all embryos strategy is still possible to consider, indicates that PTX3 level could provide additional benefit in the risk assessment for early OHSS.