bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bernard Williams as a Philosopher of Ethical Freedom
Authors: Fricker Miranda 
Published: November 2020

AbstractInterpreting Bernard Williams’s ethical philosophy is not easy. His style is deceptively conversational; apparently direct, yet argumentatively inexplicit and allusive. He is moreover committed to evading ready-made philosophical “-isms.” All this reinforces the already distinct impression that the structure of his philosophy is a web of interrelated commitments where none has unique priority. Against this impression, however, I will venture that the contours of his philosophy become clearest if one considers that there is a single, unchanging root conviction from which his ethical philosophy grows. Despite the perpetual motion of his philosophical thought—its erudition, originality, range, and unceasing forward momentum—still, I contend, there is something unchanging at the heart of it. I will show this by reference to three signature theses: internal reasons, the relativism of distance, and the porous borders of philosophy and history. I will argue that the root conviction of which these are the fruits is the conviction that the constraints of universal rationality seriously underdetermine how one should live. This, I believe, is the vision of the human ethical condition that constitutes the largely inexplicit yet utterly fundamental presupposition beneath Williams’s ethical philosophy taken as a whole. I label the object of this root conviction ethical freedom, and thus portray Williams as a philosopher of ethical freedom.
Rights and Powers in the European Union: Towards a Charter that is Fully Applicable to the Member States?
Authors: TORRES PÉREZ Aida 
Published: November 2020

AbstractThis contribution will tackle a central question for the architecture of fundamental rights protection in the EU: can we envision a Charter that fully applies to the Member States, even beyond the limits of its scope of application? To improve our understanding of the boundaries of the Charter and the potential for further expansion, I will examine the legal avenues through which the CJEU has extended the scope of application of EU fundamental rights in fields of state powers. While the latent pull of citizenship towards a more expansive application of the Charter has not been fully realized, the principle of effective judicial protection (Article 19(1) TEU) has recently shown potential for protection under EU law beyond the boundaries of the Charter. As will be argued, effective judicial protection may well become a doorway for full application of the Charter to the Member States. While such an outcome might currently seem politically unsound, I contend that a progressive case-by-case expansion of the applicability of the Charter to the Member States would be welcome from the standpoint of a robust notion of the rule of law in the EU.
The Politics of Loyalty: Understanding Voters’ Attitudes after Primary Elections
Authors: Venturino Fulvio , Seddone Antonella 
Published: November 2020

AbstractWhat happens after primary elections? Strategies of loyalty or defection in general elections have been addressed by US literature mainly by means of aggregate data. However, we lack similar studies in non-US contexts. This article investigates the strategies followed after primary elections by taking the case of the Italian Partito Democratico as an illustration. We addressed the individual drivers of loyalty or defection strategies by considering three different dimensions: (1) the outcome of the primary election, having backed a winning or losing candidate; (2) the strength of partisanship, meant as ideological congruence with the party and partisan involvement; and (3) the leader effect. We relied on four surveys (exit polls) administered during party leadership selections held in 2009, 2013, 2017 and 2019. The results suggest that all three dimensions have an influence on post-primary strategies, but what counts the most is partisan involvement.
Influence of some physico-chemical variables on wild fish richness beneath sea-cage fish farms in the Aegean Sea, Turkey
Authors: Akyol Okan , Özgül Aytaç , Ozan Düzbastılar F. , Şen Halil , Ortiz de Urbina José M. , Ceyhan Tevfik 
Published: November 2020

AbstractThis study aims to determine the relationship between physico-chemical variables on a seasonal basis and wild fish assemblages beneath sea-cage fish farms. Assemblages of wild fish were counted monthly on two separate days at each of six fish farms between August 2015 and July 2017, by six rapid visual counts (RVC) in 5 minutes with scuba by two divers. Seawater samples were simultaneously taken by a Nansen bottle during the RVC from the fish farm barge. SST (°C), salinity (ppm), dissolved oxygen (mg l−1) and pH were measured by YSI multiparameter, while Secchi disk was also used for light transmittance. Wild fish species richness went up with increasing temperature and salinity in the Izmir region, however, this stopped at about 26°C and about 39 ppm. Wild fish richness increased when the DO was at a level of 7 mg l−1 and the pH at about 7.9 in Izmir. Between 10 and 20 m, light transmittance showed greater wild fish species richness in Izmir region. In contrast, the wild fish species richness of the Muğla region fluctuated more. In terms of wild fish species richness, these fluctuations increased with salinity and DO, while they decreased with SST, pH and light transmittance. However, the range of variation of the recorded physico-chemical variables is rather narrow. The results of the correlation matrix indicate that the relationship between wild fish species richness and pH and SST was statistically significant in Izmir region (P < 0.05).
Yemeni Inscriptions, Iraqi Chronicles, Hijazi Poetry: A Reconstruction of the Meaning of Isrāʾ in Qur'an 17:1
Authors: MILLER NATHANIEL 
Published: November 2020

AbstractThe termisrāʾ, based on the first verse ofsūra 17, is typically rendered as ‘Night Journey’. There is little compelling evidence that this was the original meaning of the Qur'anic text, and medieval lexicographers and exegetes preserved a number of alternative meanings, such as thatasrāwas a denominal verb meaning ‘to travel through the uplands(al-sarāh)’. Another explanation is thatasrāis a denominal verb of the nounsariyya (pl. sarāyā), a military expedition. By drawing on early historiographical descriptions ofsarāyāand South Arabian inscriptions, which give evidence that the wordsariyyais of Sabaic origin, the Qur'anic meaning ofasrāwas evidently something like ‘to send on a royal expedition’. Early Islamic Arabic poetic texts also offer extremely compelling evidence that the first Muslims were familiar with some of the key concepts of South Arabian royal authority as they appear in Sabaic inscriptions.
Connectivity and seasonality: the 1918 influenza and COVID-19 pandemics in global perspective
Authors: Chandra Siddharth , Christensen Julia , Likhtman Shimon 
Published: November 2020

AbstractThe goal of this article is to demonstrate the value of a global perspective on pandemics for understanding how global pandemics caused by novel viruses can unfold. Using the example of the 1918 influenza pandemic, two factors that were central to the evolving pattern of global pandemic waves, connectivity and seasonality, are explored. Examples of the influences of these factors on pandemic waves in different locations are presented. Viewing the 1918 pandemic through the lens of compartmental models of infectious diseases, our analysis suggests that connectivity played a dominant role in the initial stages. With the passage of time and the progressive infection and consequent immunization of more and more people, however, the role of seasonality increased in importance, ultimately becoming the driving force behind the emergence of future waves of infection. Implications of these observations for pandemics caused by novel viruses such as the ongoing COVID-19 pandemic are discussed.
Response of grain sorghum to low rates of glufosinate and nicosulfuron
Authors: Bowman Hunter D. , Barber Tom , Norsworthy Jason K. , Roberts Trenton L. , Kelley Jason , Gbur Edward E. 
Published: November 2020

AbstractPrevious research has shown that glufosinate and nicosulfuron at low rates can cause yield loss to grain sorghum. However, research has not been conducted to pinpoint the growth stage at which these herbicides are most injurious to grain sorghum. Therefore, field tests were conducted in 2016 and 2017 to determine the most sensitive growth stage for grain sorghum exposure to both glufosinate and nicosulfuron. Field test were designed with factor A being the herbicide applied (glufosinate or nicosulfuron). Factor B consisted of timing of herbicide application including V3, V8, flagleaf, heading, and soft dough stages. Factor C was glufosinate or nicosulfuron rate where a proportional rate of 656 g ai ha−1 of glufosinate and 35 g ai ha−1 of nicosulfuron was applied at 1/10×, 1/50×, and 1/250×. Visible injury, crop canopy heights (cm), and yield were reported as a percent of the nontreated. At the V3 growth stage visible injury of 32% from the 1/10× rate of glufosinate and 51% from the 1/10× rate of nicosulfuron was observed. This injury was reduced by 4 wk after application (WAA) and no yield loss occurred. Nicosulfuron was more injurious than glufosinate at a 1/10× and 1/50× rate when applied at the V8 and flagleaf growth stages resulting in death of the shoot, reduced heading, and yield. Yield losses from the 1/10× rate of nicosulfuron were observed from V8 through early heading and ranged from 41% to 96%. Yield losses from the 1/50× rate of nicosulfuron were 14% to 16% at the flagleaf and V8 growth stages respectively. The 1/10× rate of glufosinate caused 36% visible injury 2 WAA when applied at the flagleaf stage, which resulted in a 16% yield reduction. By 4 WAA visible injury from either herbicide at less than the 1/10× rate was not greater than 4%. Results indicate that injury can occur, but yield losses are more probable from low rates of nicosulfuron at V8 and flagleaf growth stages.
Practical early cancer detection: distinguishing stable from unstable genomes in pre-cancerous tissues
Authors: Killcoyne Sarah , Fitzgerald Rebecca C. 
Published: November 2020

SummaryBarrett’s oesophagus has been known for many years to display early changes to the genome consistent with the risk for oesophageal adenocarcinoma. Recently we have shown that this information can be used without knowledge of individual gene mutations to accurately predict a patient’s future risk of malignant progression.
HDAC inhibition ameliorates cone survival in retinitis pigmentosa mice
Authors: Samardzija Marijana , Corna Andrea , Gomez-Sintes Raquel , Jarboui Mohamed Ali , Armento Angela , Roger Jerome E. , Petridou Eleni , Haq Wadood , Paquet-Durand Francois , Zrenner Eberhart , de la Villa Pedro , Zeck Günther , Grimm Christian , Boya Patricia , Ueffing Marius , Trifunović Dragana 
Published: November 2020

AbstractCone photoreceptor cell death in inherited retinal diseases, such as Retinitis Pigmentosa (RP), leads to the loss of high acuity and color vision and, ultimately to blindness. In RP, a vast number of mutations perturb the structure and function of rod photoreceptors, while cones remain initially unaffected. Extensive rod loss in advanced stages of the disease triggers cone death by a mechanism that is still largely unknown. Here, we show that secondary cone cell death in animal models for RP is associated with increased activity of histone deacetylates (HDACs). A single intravitreal injection of an HDAC inhibitor at late stages of the disease, when the majority of rods have already degenerated, was sufficient to delay cone death and support long-term cone survival in two mouse models for RP, affected by mutations in the phosphodiesterase 6b gene. Moreover, the surviving cones remained light-sensitive, leading to an improvement in visual function. RNA-seq analysis of protected cones demonstrated that HDAC inhibition initiated multi-level protection via regulation of different pro-survival pathways, including MAPK, PI3K-Akt, and autophagy. This study suggests a unique opportunity for targeted pharmacological protection of secondary dying cones by HDAC inhibition and creates hope to maintain vision in RP patients even in advanced disease stages.
Extending schizophrenia diagnostic model to predict schizotypy in first-degree relatives
Authors: Kalmady Sunil Vasu , Paul Animesh Kumar , Greiner Russell , Agrawal Rimjhim , Amaresha Anekal C. , Shivakumar Venkataram , Narayanaswamy Janardhanan C. , Greenshaw Andrew J. , Dursun Serdar M. , Venkatasubramanian Ganesan 
Published: November 2020

AbstractRecently, we developed a machine-learning algorithm “EMPaSchiz” that learns, from a training set of schizophrenia patients and healthy individuals, a model that predicts if a novel individual has schizophrenia, based on features extracted from his/her resting-state functional magnetic resonance imaging. In this study, we apply this learned model to first-degree relatives of schizophrenia patients, who were found to not have active psychosis or schizophrenia. We observe that the participants that this model classified as schizophrenia patients had significantly higher “schizotypal personality scores” than those who were not. Further, the “EMPaSchiz probability score” for schizophrenia status was significantly correlated with schizotypal personality score. This demonstrates the potential of machine-learned diagnostic models to predict state-independent vulnerability, even when symptoms do not meet the full criteria for clinical diagnosis.
Polymerase delta-interacting protein 38 (PDIP38) modulates the stability and activity of the mitochondrial AAA+ protease CLPXP
Authors: Strack Philip R. , Brodie Erica J. , Zhan Hanmiao , Schuenemann Verena J. , Valente Liz J. , Saiyed Tamanna , Lowth Bradley R. , Angley Lauren M. , Perugini Matthew A. , Zeth Kornelius , Truscott Kaye N. , Dougan David A. 
Published: November 2020

AbstractOver a decade ago Polymerase δ interacting protein of 38 kDa (PDIP38) was proposed to play a role in DNA repair. Since this time, both the physiological function and subcellular location of PDIP38 has remained ambiguous and our present understanding of PDIP38 function has been hampered by a lack of detailed biochemical and structural studies. Here we show, that human PDIP38 is directed to the mitochondrion in a membrane potential dependent manner, where it resides in the matrix compartment, together with its partner protein CLPX. Our structural analysis revealed that PDIP38 is composed of two conserved domains separated by an α/β linker region. The N-terminal (YccV-like) domain of PDIP38 forms an SH3-like β-barrel, which interacts specifically with CLPX, via the adaptor docking loop within the N-terminal Zinc binding domain of CLPX. In contrast, the C-terminal (DUF525) domain forms an immunoglobin-like β-sandwich fold, which contains a highly conserved putative substrate binding pocket. Importantly, PDIP38 modulates the substrate specificity of CLPX and protects CLPX from LONM-mediated degradation, which stabilises the cellular levels of CLPX. Collectively, our findings shed new light on the mechanism and function of mitochondrial PDIP38, demonstrating that PDIP38 is a bona fide adaptor protein for the mitochondrial protease, CLPXP.
Genome editing in plants using CRISPR type I-D nuclease
Authors: Osakabe Keishi , Wada Naoki , Miyaji Tomoko , Murakami Emi , Marui Kazuya , Ueta Risa , Hashimoto Ryosuke , Abe-Hara Chihiro , Kong Bihe , Yano Kentaro , Osakabe Yuriko 
Published: November 2020

AbstractGenome editing in plants has advanced greatly by applying the clustered regularly interspaced short palindromic repeats (CRISPRs)-Cas system, especially CRISPR-Cas9. However, CRISPR type I—the most abundant CRISPR system in bacteria—has not been exploited for plant genome modification. In type I CRISPR-Cas systems, e.g., type I-E, Cas3 nucleases degrade the target DNA in mammals. Here, we present a type I-D (TiD) CRISPR-Cas genome editing system in plants. TiD lacks the Cas3 nuclease domain; instead, Cas10d is the functional nuclease in vivo. TiD was active in targeted mutagenesis of tomato genomic DNA. The mutations generated by TiD differed from those of CRISPR/Cas9; both bi-directional long-range deletions and short indels mutations were detected in tomato cells. Furthermore, TiD can be used to efficiently generate bi-allelic mutant plants in the first generation. These findings indicate that TiD is a unique CRISPR system that can be used for genome engineering in plants.
Ancient DNA reveals monozygotic newborn twins from the Upper Palaeolithic
Authors: Teschler-Nicola Maria , Fernandes Daniel , Händel Marc , Einwögerer Thomas , Simon Ulrich , Neugebauer-Maresch Christine , Tangl Stefan , Heimel Patrick , Dobsak Toni , Retzmann Anika , Prohaska Thomas , Irrgeher Johanna , Kennett Douglas J. , Olalde Iñigo , Reich David , Pinhasi Ron 
Published: November 2020

AbstractThe Upper Palaeolithic double burial of newborns and the single burial of a ca. 3-month-old infant uncovered at the Gravettian site of Krems-Wachtberg, Austria, are of paramount importance given the rarity of immature human remains from this time. Genome-wide ancient DNA shows that the male infants of the double grave are the earliest reported case of monozygotic twins, while the single grave´s individual was their 3rd-degree male relative. We assessed the individuals´ age at death by applying histological and µCT inspection of the maxillary second incisors (i2) in conjunction with C- and N-isotope ratios and Barium (Ba) intake as biomarker for breastfeeding. The results show that the twins were full-term newborns, and that while individual 2 died at birth, individual 1 survived for about 50 days. The findings show that Gravettian mortuary behaviour also included re-opening of a grave and manipulation of its layout and content.
Scanning electrochemical microscopy screening of CO2 electroreduction activities and product selectivities of catalyst arrays
Authors: Mayer Francis D. , Hosseini-Benhangi Pooya , Sánchez-Sánchez Carlos M. , Asselin Edouard , Gyenge Előd L. 
Published: November 2020

AbstractThe electroreduction of CO2 is one of the most investigated reactions and involves testing a large number and variety of catalysts. The majority of experimental electrocatalysis studies use conventional one-sample-at-a-time methods without providing spatially resolved catalytic activity information. Herein, we present the application of scanning electrochemical microscopy (SECM) for simultaneous screening of different catalysts forming an array. We demonstrate the potential of this method for electrocatalytic assessment of an array consisting of three Sn/SnOx catalysts for CO2 reduction to formate (CO2RF). Simultaneous SECM scans with fast scan (1 V s−1) cyclic voltammetry detection of products (HCOO−, CO and H2) at the Pt ultramicroelectrode tip were performed. We were able to consistently distinguish the electrocatalytic activities of the three compositionally and morphologically different Sn/SnOx catalysts. Further development of this technique for larger catalyst arrays and matrices coupled with machine learning based algorithms could greatly accelerate the CO2 electroreduction catalyst discovery.
Diels–Alder reactions and electrophilic substitutions with atypical regioselectivity enable functionalization of terminal rings of anthracene
Authors: Huynh Vinh Ngoc , Leitner Michael , Bhattacharyya Aditya , Uhlstein Lisa , Kreitmeier Peter , Sakrausky Patrick , Rehbein Julia , Reiser Oliver 
Published: November 2020

AbstractReversing the regioselectivity of the renowned Diels–Alder reaction by overriding the usual thermodynamic and kinetic governing factors has always been a formidable challenge to synthetic organic chemists. Anthracenes are well-known to undergo [4 + 2]-cycloadditions with dienophiles at their 9,10-positions (central ring) over 1,4-positions (terminal ring) guided by the relative aromatic stabilization energy of the two possible products, and also by harboring the largest orbital coefficients of the highest occupied molecular orbital (HOMO) at the 9,10-positions. We, herein, report a 1,4-selective [4 + 2]-cycloaddition strategy of 9,10-unsubstituted anthracenes by installing electron-donating substituents on the terminal rings which is heretofore unprecedented to the best of our knowledge. The developed synthetic strategy does not require any premeditated engagement of the 9,10-positions either with any sterically bulky or electron-withdrawing substituents and allows delicate calibration of the regioselectivity by modulating the electron-donating strength of the substituents on the terminal rings. Likewise, the regioselective functionalization of the terminal anthracene ring in electrophilic substitution reactions is demonstrated. A mechanistic rationale is offered with the aid of detailed computational studies, and finally, synthetic applications are presented.
The impact of travel and timing in eliminating COVID-19
Authors: Siegenfeld Alexander F. , Bar-Yam Yaneer 
Published: November 2020

AbstractWhile the spread of communicable diseases such as coronavirus disease 2019 (COVID-19) is often analyzed assuming a well-mixed population, more realistic models distinguish between transmission within and between geographic regions. A disease can be eliminated if the region-to-region reproductive number—i.e., the average number of other regions to which a single infected region will transmit the disease—is reduced to less than one. Here we show that this region-to-region reproductive number is proportional to the travel rate between regions and exponential in the length of the time-delay before region-level control measures are imposed. If, on average, infected regions (including those that become re-infected in the future) impose social distancing measures shortly after experiencing community transmission, the number of infected regions, and thus the number of regions in which such measures are required, will exponentially decrease over time. Elimination will in this case be a stable fixed point even after the social distancing measures have been lifted from most of the regions.