bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frey Procedure Combined with Biliary Diversion for the Treatment of Chronic Pancreatitis‐Related Biliary Obstruction: Impact of the Types of Diversion
Authors: Ray Sukanta , Das Kshaunish , Jana Koustav , Das Roby , Kumar Dilip , Khamrui Sujan 
Published: March 2020

AbstractBackgroundFrey procedure (FP) has become the standard of treatment for patients with painful chronic pancreatitis and inflammatory head mass. Biliary diversion (BD) is necessary when there is persistent biliary obstruction after adequate head coring. The aim of the present study was to assess the impact of types of biliary diversion on short‐term outcome and rates of stricture recurrence.MethodsAll the patients, who underwent FP combined with BD between August 2007 and July 2017 in the Department of Surgical gastroenterology, Institute of Postgraduate Medical Education and Research, Kolkata, India, were retrospectively reviewed. The types of BD performed were choledochojejunostomy (Group A) or opening of the CBD in the resection cavity (Group B).ResultsDuring the study period, 36 patients underwent FP with BD. Choledochojejunostomy was performed in 21 patients and opening of the CBD in the resection cavity in 15 patients. Preoperative characteristics and early surgical outcomes were comparable except the postoperative stay which was longer in those who underwent choledochojejunostomy (p = 0.044). Pain control was similar. Over a median follow‐up of 72 months, five patients in the Group B developed stricture recurrence which was significantly higher than those of Group A (p = 0.008).ConclusionCholedochojejunostomy combined with FP achieves efficient BD with a lower rate of restricture compared with opening of the CBD in the resection cavity.
Improved covering-based collaborative filtering for new users’ personalized recommendations
Authors: Zhang Zhipeng , Kudo Yasuo , Murai Tetsuya , Ren Yonggong 
Published: March 2020

AbstractUser-based collaborative filtering (UBCF) is widely used in recommender systems (RSs) as one of the most successful approaches, but traditional UBCF cannot provide recommendations with satisfactory accuracy and diversity simultaneously. Covering-based collaborative filtering (CBCF) is a useful approach that we have proposed in our previous work, which greatly improves the traditional UBCF and could provide satisfactory recommendations to an active user which often has sufficient rating information. However, different from an active user, a new user in RSs often has special characteristics (e.g., fewer ratings or ratings concentrating on popular items), and the previous CBCF approach cannot provide satisfactory recommendations for a new user. In this paper, aiming to provide personalized recommendations for a new user, through a detailed analysis of the characteristics of new users, we reconstruct a decision class to improve the previous CBCF and utilize the covering reduction algorithm in covering-based rough sets to remove redundant candidate neighbors for a new user. Furthermore, unlike the previous CBCF, our improved CBCF could provide personalized recommendations without needing special additional information. Experimental results suggest that for the sparse datasets that often occur in real RSs, the improved CBCF significantly outperforms those of existing work and can provide personalized recommendations for a new user with satisfactory accuracy and diversity simultaneously.
Diamide resistance: 10 years of lessons from lepidopteran pests
Authors: Richardson Ewan B. , Troczka Bartlomiej J. , Gutbrod Oliver , Davies T. G. Emyr , Nauen Ralf 
Published: March 2020

AbstractDiamide insecticides selectively acting on insect ryanodine receptors (RyR) were launched to the market more than 10 years ago, particularly targeted for the control of lepidopteran pest species in diverse agronomic and horticultural cropping systems. They are now globally registered in many countries and provide reliable control levels in most settings. However, their frequent application, due to alternative mode of action chemistries often not providing sufficient levels of control, has resulted in the selection of diamide resistance in some of the world’s most destructive lepidopteran species, including populations of diamondback moth, tomato leafminer, rice stem borer and more recently beet armyworm. High levels of diamide resistance, compromising diamide efficacy at recommended field rates, has been shown to be conferred by RyR target-site mutations affecting diamide binding. The present work reviews the global status of diamide insecticide resistance in lepidopteran pests, with special reference to RyR target-site alterations. Furthermore, we discuss principles enabling the prediction of the impact and spread of diamide resistance, based on population genetics and associated fitness costs as influenced by the known target-site mutations recently described. In this context, we reiterate calls by the Insecticide Resistance Action Committee to implement effective diamide insecticide resistance management by following a three-step strategy of resistance identification, tracking and prediction according to the protocols discussed in this article.
Current role of ultrasound in the diagnosis of hepatocellular carcinoma
Authors: Tanaka Hironori 
Published: March 2020

AbstractUltrasonography (US) is a major, sustainable hepatocellular carcinoma (HCC) surveillance method as it provides inexpensive, real-time, and noninvasive detection. Since US findings are based on pathological features, knowledge of pathological features is essential for delivering a correct US diagnosis. Recent advances in US equipment have made it possible to provide more information, such as malignancy potential and accurate localization diagnosis of HCC. Evaluation of malignancy potential is important to determine the treatment strategy, especially for small HCC. Diagnosis of blood flow dynamics using color Doppler and contrast-enhanced US is one of the most definitive approaches for evaluating HCC malignancy potential. Recently, a new Doppler microvascular imaging technique, superb microvascular imaging, which can detect Doppler signals generated by low-velocity blood flow, was developed. A fusion imaging system, another innovative US technology, has already become an indispensable technology over the last few years not only for US-guided radiofrequency ablation but also for the detection of small, invisible HCC. This article reviews the evidence on the use of ultrasound and contrast-enhanced ultrasound with Sonazoid for the practical management of HCC.
Differential effects of Cu2+ and Fe3+ ions on in vitro amyloid formation of biologically-relevant α-synuclein variants
Authors: Lorentzon Emma , Kumar Ranjeet , Horvath Istvan , Wittung-Stafshede Pernilla 
Published: March 2020

AbstractAlterations in metal ion homeostasis appear coupled to neurodegenerative disorders but mechanisms are unknown. Amyloid formation of the protein α-synuclein in brain cells is a hallmark of Parkinson’s disease. α-Synuclein can bind several metal ions in vitro and such interactions may affect the assembly process. Here we used biophysical methods to study the effects of micromolar concentrations of Cu2+ and Fe3+ ions on amyloid formation of selected α-synuclein variants (wild-type and A53T α-synuclein, in normal and N-terminally acetylated forms). As shown previously, Cu2+ speeds up aggregation of normal wild-type α-synuclein, but not the acetylated form. However, Cu2+ has a minimal effect on (the faster) aggregation of normal A53T α-synuclein, despite that Cu2+ binds to this variant. Like Cu2+, Fe3+ speeds up aggregation of non-acetylated wild-type α-synuclein, but with acetylation, Fe3+ instead slows down aggregation. In contrast, for A53T α-synuclein, regardless of acetylation, Fe3+ slows down aggregation with the effect being most dramatic for acetylated A53T α-synuclein. The results presented here suggest a correlation between metal-ion modulation effect and intrinsic aggregation speed of the various α-synuclein variants.
Image-based stroke rat brain atrophy volume and infarct volume computation
Authors: Chan Yung-Kuan , Hong Chun-Fu , Tsai Meng-Hsiun , Chang Ya-Lan , Sun Ping-Hsuan 
Published: March 2020

AbstractStroke is one of the leading causes of death as well as results in a massive economic burden for society. Stroke is a cerebrovascular disease mainly divided into two types: ischemic stroke and hemorrhagic stroke, which, respectively, refer to the partial blockage and bleeding inside brain blood vessels. Both stroke types lead to nutrient and oxygen deprivation in the brain, which ultimately cause brain damage or death. This study focuses on ischemic stroke in rats with middle cerebral artery occlusion (MCAO) as experimental subjects, and the volumes of infarct and atrophy are calculated based on the brain slice images of rat brains stained with 2,3,5-triphenyl tetrazolium chloride. In this study, a stroke rat brain infarct and atrophy volumes computation system (SRBIAVC system) is developed to segment the infarcts and atrophies from the rat brain slice images. Based on the segmentation results, the infarct and atrophy volumes of a rat brain can be computed. In this study, 168 images of brain slices cut from 28 rat brains with MCAO are used as the test samples. The experimental results show that the segmentation results obtained by the SRBIAVC system are close to those obtained by experts.
Visfatin as a predictor of obstructive sleep apnea in atrial fibrillation patients
Authors: Szymanska Anna , Platek Anna E. , Sierdzinski Janusz , Szymanski Filip M. 
Published: March 2020

Abstract
Background
Obstructive sleep apnea (OSA) often coexists with atrial fibrillation (AF) and makes the course of AF worse. The negative impact of OSA on AF may be due to atrial stretch, hypoxia, hypertension, obesity, fibrosis, and inflammation. Several mediators are thought to be responsible for this correlation, among them adipokines such as visfatin. This study aimed to assess the association between visfatin concentrations and OSA in patients with AF.

Aims
This study aimed to assess the association between visfatin concentrations and OSA in AF patients.

Methods
In a tertiary Cardiology Department, hospitalized patients previously diagnosed with AF were enrolled in the study. Diagnosis of OSA was made based on a respiratory polygraphy and patients had blood samples taken for assessment of plasma visfatin concentration.

Results
A total of 266 patients with AF (65% men, age 57.6 ± 10.1) were enrolled, and 121 (45%) were diagnosed with OSA. Patients with OSA had higher visfatin concentrations than those without OSA (2.13 ± 0.17 vs. 1.70 ± 0.21 ng/mL; p = 0.04). Patients with mild OSA had visfatin levels equal to 1.77 ± 0.17 ng/mL, moderate OSA 2.38 ± 0.18 ng/mL, and severe OSA 3.55 ± 0.61 ng/mL (p for trend = 0.017). Multivariate regression analysis showed that increased visfatin concentrations were associated with the risk of OSA (odds ratio 1.92; 95% confidence interval 1.09–3.40).

Conclusions
Patients with AF who were diagnosed with OSA had significantly higher plasma visfatin levels which increased according to the severity of OSA. Furthermore, multivariate regression analysis identified visfatin concentration over 1.25 ng/mL, male sex, age over 59.1 years, and permanent AF as the factors showing independent correlation with OSA.
Status of contaminated marine sediments in four Nordic countries: assessments, regulations, and remediation approaches
Authors: Lehoux Alizée P. , Petersen Karina , Leppänen Matti T. , Snowball Ian , Olsen Marianne 
Published: March 2020

Abstract
Purpose
Since the 1960s, pollution of the marine environment has been observed around the world, and a general awareness of the potential environmental hazards from contaminants arose. This general awareness was followed by implementation of environmental regulations at the national and international levels regarding industrial discharges, and forcing the development of management programs to improve the environmental quality. This overview focuses on the status of assessments, regulations, and remediation actions of contaminated marine sediments in four North European countries: Sweden, Norway, Finland, and Denmark.

Results and discussion
We found that the extent of assessment surveys and the implementation of sediment remediation actions vary between the countries, with Norway the most advanced. Norway has initiated national pilot remediation tests, followed by full-scale site remediation by dredging and in situ capping in several projects along the coast. Sweden is following Norway’s example, although with fewer completed projects. In Finland, the tradition of maintenance dredging is still very strong although the main purpose has not been cleanup actions. Accordingly, in Denmark, dredging is primarily used to maintain sailing depths. All four countries have implemented the Water Framework Directive in addition to national regulations that provide the authority for imposing and implementing sediment remediation measures. However, only Norway has implemented a national strategy on remediation of contaminated sediments.

Conclusions
This overview highlights the need for enhanced communication and exchange of experiences between the four Nordic countries of concern with regard to sediment remediation strategy and management.
Sediment load variability in response to climate and land use changes in a Carpathian catchment (Raba River, Poland)
Authors: Szalińska Ewa , Orlińska-Woźniak Paulina , Wilk Paweł 
Published: March 2020

Abstract
Purpose
This study analyzes the variability of sediment loads under variant climate change and land use scenarios in a Carpathian catchment with a dam reservoir. The areas with the highest share of sediment loads are tracked to establish possible indications for future catchment management plans.

Materials and methods
Analyses were performed for the Raba River catchment (Poland, Carpathian Mountains) with use of the Macromodel DNS/SWAT. The RCP 4.5 climate forecast predictions (2021–2050 and 2071–2100), downscaled for the area of Poland, and land use predictions from the DYNA-Clue model for the Carpathian area, were taken into consideration. A total of seven scenarios were created, accounting for precipitation (P1 and P2), temperature (T1 and T2), land use (LU) changes, and combined effects (COMB1 and COMB2).

Results and discussion
The average load delivered to the dam reservoir was estimated as 2.43 Gg y−1, and its seasonal/yearly variability was followed by local meteorological phenomena. Among the tested factors, precipitation change, in terms of total amount and intensity, exerted the most impact on sediment loads causing their increase. Temperature and land use changes resulted in a slight decrease. Combined scenarios implied that changes of the catchment area use, such as increase of forest cover, can noticeably reduce sediment loads delivered into a dam reservoir.

Conclusions
The performed simulations revealed the importance of incorporating variant scenarios for catchment management plans, development of land use mitigation measures (erosion), and operational procedures for the dam reservoir. Particular attention should be paid to warmer winters with heavy rainfalls and temperatures above zero, which together with a lack of plant vegetation result in elevated annual sediment loads reaching the dam reservoir. Further changes must be mitigated by anti-erosion investments.
Fairness criteria for allocating scarce resources
Authors: Singh Bismark 
Published: March 2020

AbstractWe develop an optimization model to provide a fair allocation of multiple resources to multiple users. All resources might not be suitable to all users. We develop a notion of fairness, and then provide a general class of functions achieving it. Next, we develop more restricted notions of fairness—special cases of which exist in literature. Finally, we distinguish between scarce and abundant resources, and show that if a resource is abundant, all users seeking it achieve the maximum possible coverage.
Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection
Authors: Zou Xin , Chen Ke , Zou Jiawei , Han Peiyi , Hao Jie , Han Zeguang 
Published: March 2020

AbstractIt has been known that, the novel coronavirus, 2019-nCoV, which is considered similar to SARS-CoV, invades human cells via the receptor angiotensin converting enzyme II (ACE2). Moreover, lung cells that have ACE2 expression may be the main target cells during 2019-nCoV infection. However, some patients also exhibit non-respiratory symptoms, such as kidney failure, implying that 2019-nCoV could also invade other organs. To construct a risk map of different human organs, we analyzed the single-cell RNA sequencing (scRNA-seq) datasets derived from major human physiological systems, including the respiratory, cardiovascular, digestive, and urinary systems. Through scRNA-seq data analyses, we identified the organs at risk, such as lung, heart, esophagus, kidney, bladder, and ileum, and located specific cell types (i.e., type II alveolar cells (AT2), myocardial cells, proximal tubule cells of the kidney, ileum and esophagus epithelial cells, and bladder urothelial cells), which are vulnerable to 2019-nCoV infection. Based on the findings, we constructed a risk map indicating the vulnerability of different organs to 2019-nCoV infection. This study may provide potential clues for further investigation of the pathogenesis and route of 2019-nCoV infection.
A Combined Proteomics and Bioinformatics Approach Reveals Novel Signaling Pathways and Molecular Targets After Intracerebral Hemorrhage
Authors: Dasari Rajaneekar , Zhi Wenbo , Bonsack Frederick , Sukumari-Ramesh Sangeetha 
Published: March 2020

AbstractIntracerebral hemorrhage (ICH) is a non-traumatic cerebrovascular disorder with very high morbidity and mortality and regarded as one of the deadliest stroke subtypes. Notably, there is no effective treatment for ICH. Despite an overall increase in preclinical studies, the pathophysiology of ICH is complex and remains enigmatic. To this end, ICH was induced in male CD-1 mice and the ipsilateral brain tissue was characterized in an unbiased manner using a combination of proteomics and bioinformatics approaches. A total of 4833 proteins were revealed by quantitative proteomic analysis. Of those, 207 proteins exhibited significantly altered expression after ICH in comparison to sham. It was found that 46 proteins were significantly upregulated and 161 proteins were significantly downregulated after ICH compared to sham. The quantitative proteomics approach combined with bioinformatics revealed several novel molecular targets (cyclin-dependent-like kinase 5, E3 ubiquitin-protein ligase, protein phosphatase 2A-alpha, protein phosphatase 2A-beta, serine/threonine-protein kinase PAK1, alpha-actinin-4, calpain-8, axin-1, NCK1, and septin-4), and related signaling pathways, which could play roles in secondary brain injury and long-term neurobehavioral outcomes after ICH warranting further investigation.
Hominid sexual nature
Authors: Mogielnicki Christopher , Pearl Katherine 
Published: March 2020

AbstractThe aim of the paper is to identify psychosomatic evolutionary adaptations of hominids, which direct them at maximizing their reproductive success, and on the basis of which their various social structures are built. Selected features of the hominid last common ancestor were extracted; by reducing the influence of the social structure, they were defined as the hominid “sexual nature”; these considerations were supported by the analysis of sexual jealousy as a function of socio-environmental conditions. The “sexuality core” of a hominid female was defined as “selective polyandry”—the female selects the best males among those available; and of a hominid male as “tolerant promiscuity”—the male strives for multi-male and multi-female copulations with sexually attractive females. The extracted “sexuality cores” condemn hominids to a patriarchal social structure and thus to sexual coercion and jealousy. The source of male sexual jealousy is limited access to females. Hominid female jealousy of the male results mainly from the need for protection and support. Hominids’ social structures are determined by females’ sexual selectivity or opportunism and by their continuous or periodic proceptivity and estrus signaling. Evolutionary functions developed by women: out-estrus sexuality, copulation calls, multiple orgasms, allow them to obtain the best possible spermatozoid. The institution of marriage blocks the influence of sexual selection in the species Homo sapiens.
Obstipation and diarrhoea in palliative care—a pharmacist’s view
Authors: Aretin Marie-Bernadette 
Published: March 2020

SummaryThis article is a brief overview of drugs, which are of use in the treatment of constipation and diarrhoea in palliative care. Whereas most of the drugs mentioned are widely used and known, the aspect of gastrointestinal symptoms as side effect of pharmacological treatments is often underestimated. Therefore, the article highlights the approach of deprescribing, as a tool to reduce both, pill burden and symptoms.
IoT-commerce - opportunities for customers through an affordance lens
Authors: Bayer Sarah , Gimpel Henner , Rau Daniel 
Published: March 2020

AbstractRetail commerce is influenced by digital technologies at large scale. After electronic commerce and its evolution into mobile commerce, we now see that the Internet of Things (IoT), one of the most disruptive developments in recent times, is about to radically transform retail commerce from need recognition to post-purchase engagement and service. Extant literature mainly investigates technical features of IoT, missing out on a customer-centric perspective. Theoretically founded in Activity and Affordance Theories, this paper conceptualizes IoT-commerce, identifies opportunities for customers, and links them to the customer buying process. Based on an extensive literature review, twelve affordances are derived and evaluated with a sample of real-world IoT devices. All affordances offered by electronic and mobile commerce are still valid for IoT-commerce but extended by three affordances unique to IoT-commerce: context-aware services, natural interactions, and automated customer processes. Affecting all steps of the customer buying process, IoT-commerce is worth to be understood by researchers, customers, and companies.
Numerical and ANFIS modeling of flow over an ogee-crested spillway
Authors: Yildiz Ali , Yarar Alpaslan , Kumcu S. Yurdagul , Marti Ali Ihsan 
Published: March 2020

AbstractThe main aim of this study was to investigate the flow over an ogee spillway experimentally and simulating by both ANFIS and numerical model. An experimental study was conducted in order to obtain discharges and flow depths over an ogee spillway. Discharges and flow depths of flow in physical model were measured for 16 different total heads. A computational fluid dynamics program, which uses the Reynolds averaged Navier–Stokes equations to solve fluid problems, was used to simulate the flow over ogee spillway. As artificial intelligence methods have also been used with increasing the computer technology in all engineering problems, it was also used in this study in estimating the flow over the spillway. Finally, the flow parameters observed by physical study, numerical simulation and ANFIS model were compared with each other. Nondimensional discharge and flow depth curves are used to compare the results. Numerical and ANFIS models provide a cost-efficient simulating flow over spillways. The results show that there is reasonably good agreement between the physical, numerical and ANFIS models. Numerical solution methods and ANFIS models are also useful tools to design and analyze flow over an ogee spillway.