bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the therapeutic effect of high-flow nasal cannula oxygen therapy on patients with aspiration pneumonia accompanied by respiratory failure in the post-stroke sequelae stage
Authors: Xing Dong , Chen Yu-Hong , Wang Lan-Tao , Yu Bin , Ran Zhi-Bin , Chen Li 
Published: July 2020

Abstract
Background: The aim of the present study was to evaluate the therapeutic effect of high-flow nasal cannula (HFNC) oxygen therapy on patients with aspiration pneumonia accompanied by respiratory failure in the post-stroke sequelae stage, with the goal of providing more effective oxygen therapy and improving patient prognosis.Methods: Retrospective analysis was conducted on 103 elderly patients with post-stroke aspiration pneumonia and moderate respiratory failure (oxygenation index: 100–200 mmHg) that had been admitted. The patients were divided into two groups according to the mode of oxygen therapy that was used: the Venturi mask group and the HFNC treatment group. The two groups were analyzed and compared in terms of the changes in the blood gas indices measured at different points in time (4, 8, 12, 24, 48, and 72 h), the proportion of patients that required transition to invasive auxiliary ventilation, and the 28-day mortality rate.Results: 103 patients were retrospectively analyzed; 16 cases were excluded, and 87 patients were included in the final patient group (42 in the HFNC group and 45 in the Venturi group). There was a statistically significant difference in the oxygenation indices of the HFNC group and the Venturi group (F = 546.811, P < 0.05). There was a statistically significant interaction between the monitored oxygenation indices and the mode of oxygen therapy (F = 70.961, P < 0.05), and there was a statistically significant difference in the oxygenation indices for the two modes of oxygen therapy (F = 256.977, P < 0.05). HFNC therapy contributed to the improvement of the oxygenation indices at a rate of 75.1%. The Venturi and HFNC groups also differed significantly in terms of the proportion of patients that required transition to invasive auxiliary ventilation within 72 h (P < 0.05). The HFNC group’s risk for invasive ventilation was 0.406 times that of the Venturi group (P < 0.05). There was no statistical difference in the 28-day mortality rate of the two groups (P > 0.05).Conclusion: HFNC could significantly improve the oxygenation state of patients with post-stroke aspiration pneumonia and respiratory failure, and it may reduce the incidence of invasive ventilation.
The Important Herbal Pair for the Treatment of COVID-19 and Its Possible Mechanisms
Authors: Xia Shujie , Zhong Zhangfeng , Gao Bizhen , Vong Chi Teng , Cai Jin , Lin Xuejuan , Chen Shujiao , Chan Ging , Li CanDong 
Published: July 2020

Abstract
Background: Corona Virus Disease 2019 (COVID-19) is an unprecedented disaster for people around the world. Many studies have shown that traditional Chinese medicines(TCM) are indeed effective in treating COVID-19. However, it is a hard work to find the most effective combination laws among numerous herbs as well as its potential mechanisms. The purpose of this article is to explore the combination laws of traditional Chinses medicine(TCM) prescriptions and pick out the most important herbal pair for treating COVID-19 and analyze the active components and potential mechanisms. Methods: We first systematically sorted out the TCM prescriptions recommended by leading experts for treating COVID-19 and the specific herbs they contained in different stages of disease. Next, the association rule approach was employed to examine the distribution and combination laws among these TCM prescription, and then picked out the most important herbal pair. On this basis, we further investigated the active ingredients and potential targets in the selected herbal pair by a network pharmacology approach. Result: We obtained 32 association rules for herb combinations in the process of TCM treatment for COVID-19. It was found that the combination of Amygdalus Communis Vas(ACV) and Ephedra sinica Stapf (ESS) had the highest confidence degree and lift value as well as high support degree, which can be used in almost all stages of COVID-19, so ACV and ESS (AE) was selected as the most important herbal pair. There were 26 active ingredients and 44 potential targets, which may be relate to the herbal pair of AE against COVID-19. The main active ingredients of AE against COVID-19 are quercetin, kaempferol, luteolin and the potential important targets are Interleukin 6 (IL-6), Mitogen-activated Protein Kinase 1 (MAPK)1, MAPK8, Interleukin-1β (IL-1β), Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) p65 subunit (RELA) and so on. The protein-protein interaction (PPI) cluster demonstrated that IL-6 was the seed in the cluster, which plays an important role in connecting other nodes in the PPI network. The significant pathways mainly involved in tumor necrosis factor (TNF), Toll-like receptor (TLR), hypoxia-inducible factor-1 (HIF-1), nucleotide-binding oligomerization domain (NOD)-like receptor(NLRs). Conclusion: Amygdalus Communis Vas and Ephedra sinica Stapf was the most important herbal pair in the treatment of COVID-19. The main active ingredients of AE against COVID-19 were quercetin, kaempferol, luteolin and the important targets were IL-6，MAPK1, MAPK8, IL-1β, RELA and so on. AE may have therapeutic effects against COVID-19 by affecting the pathological processes such as inflammatory and immune responses, cell apoptosis, hypoxia damage and other pathological processes through multiple components, multiple targets and multiple pathways.
The capacity-building role of Community Liaison Workers with refugee communities in Victoria, Australia
Authors: Chopra Prem , Wei Karen , Strehlow Susie , Stow Mardi , Kaplan Ida , Szwarc Josef , Minas Harry 
Published: July 2020

Abstract
Background

A range of services within Australia and internationally have been developed that are focused on the engagement of individuals who are of refugee background to work as a liaison between their communities and mental health services. The Community Liaison Worker (CLW) role at the Victorian Foundation for Survivors of Torture (VFST) was developed in 2008 in order to engage in such capacity-building initiatives.
Aims

To review and document the establishment, evolution and current status of the VFST CLW role, and examine the perspectives of CLWs on their role in trauma-informed community capacity-building.
Methods

The study comprised of two stages: a historical case study of the development of the CLW role, and a qualitative research study based on interviews with CLWs in order to identify key themes regarding various aspects of their role and understand the facilitators and barriers to their work of trauma-informed capacity-building with their respective communities.
Results

The CLW role has evolved from the provision of direct services through joint work with Counsellor Advocates at VFST to a broader role that is focused on building the capacity of community members. Thematic analysis of interviews with the seven current CLWs identified the complexity of their dual role as members of their community and employees of VFST, their role in addressing short-term goals to meet community needs, and the long-term objective of empowering their community to become integrated and self-sufficient.
Conclusions

CLWs at VFST demonstrate important work of Liaison Workers in facilitating trauma-informed capacity-building initiatives that are of benefit to members of their communities and also to service providers.
Inverse Correlation between Age and Risk of Lymph Node Metastasis in Bladder Cancer
Authors: Ma Wenchao , Wang Tiantian , Guo Yadong , Wang Ruiliang , Liu Ji , Li Cheng , Maskey Niraj , Zhang Wentao , Yao Xudong 
Published: July 2020

Abstract
Background Bladder cancer (BCa) is the most common malignant tumor in humans and brings about a huge burden on the international community and on the families of those it affects. Lymph node metastasis (LNM) is an important factor affecting the prognosis of BCa. This study aimed to investigate the risk factors affecting LNM.Patients and Methods This study involved 5517 patients who underwent BCa-related surgery between 2006 and 2015. The multivariate logistic regression analysis was used to evaluate the association between age and LNM. The overall survival (OS) and cancer-specific survival (CSS) were analyzed using the Kaplan–Meier method. The multivariable Cox regression model was used to evaluate independent risk factors affecting OS and CSS.Results We retrieved 5517 cases from SEER database, including 148 patients aged 40-49 years, 726 aged 50-59 years, 1541 aged 60-69 years, 1538 aged 70-79 years and 1564 aged 80+ years. The rates of LNM were 20.27%, 16.94%, 11.94%, 9.95% and 6.46% for patients aged 40-49, 50-59, 60-69, 70-79 and 80+ years. We found an inverse correlation between age at diagnosis and risk of LNM from the logistic regression analysis in three modules(Module 1: P-value for trend, crude, no adjustment < 0.001; Module 2: P-value for trend adjusted for sex, race, insurance status, and marital status < 0.001; Module 3: P-value for trend adjusted for sex, race, insurance, marital status, size, grade, and metastasis < 0.001). Compared with patients aged 40–49 years, patients aged 50–59 years (OR = 0.752; 95% CI, 0.470–1.204; P = 0.236), 60–69 years (OR = 0.517; 95% CI, 0.329–0.815; P = 0.004), 70–79 years (OR = 0.375; 95% CI, 0.237–0.595; P < 0.001), and 80+ years (OR = 0.248; 95% CI, 0.154–0.398; P < 0.001) had a lower risk of LNM.ConclusionsYounger age at diagnosis was associated with a higher risk of LNM in patients with BCa. Excepting this, grade and metastasis were also risk factors for LNM.
Metabolic Bone Disease in Chronic Kidney Disease Patients (CKD-MBD) and its Associated Factors at Muhimbili National Hospital in Dar es salaam, Tanzania: A Cross-Sectional Study
Authors: MUNGULLUH FELIX FAUSTIN , Ruggajo Paschal , Furia Francis F. 
Published: July 2020

Abstract
Background: Metabolic bone disease in chronic kidney disease patients is associated with high morbidity and mortality, and it has been reported to start early in the course of the disease and worsen as the kidney damage progresses. However, the prevalence and factors associated with metabolic bone disease in chronic kidney disease patients in our setting has not been established, so we aimed to determine the prevalence and factors associated with metabolic bone disease among patients with chronic kidney disease at a tertiary Muhimbili National Hospital in Dar es salaam, Tanzania so as to help physicians recognize the patients at risk, diagnose the problem and prevent complications sooner.Methods: This was a hospital based cross-sectional study involving adult patients with chronic kidney disease attending renal unit Muhimbili National Hospital, a tertiary referral center in Dar es Salaam, Tanzania. Systematic sampling technique was employed to get study participants after being given informed consent. In this study, CKD-MBD was defined basing on the abnormality of serum calcium, phosphate or parathyroid hormone level. Data analysis was done using the SPSS version 23.0 software.Results: A total of 300 participants with chronic kidney disease stage 3 and above were included in this study. Majority were male, 198 (66.0%), with a mean age of 53 years. The prevalence of metabolic bone disease was found to be 75.0%. The most common form of metabolic bone disease was hyperparathyroidism 196 (87.1%), followed by hypocalcemia 174 (77.3%) and hyperphosphatemia 82 (36.4%), which was the least common. Factors which were found to be significantly associated with CKD-MBD were the use of calcium supplements, use of phosphate binders, being on dialysis, a calcium rich diet and a low phosphate diet.Conclusion: Metabolic bone diseases are common in patients with CKD at Muhimbili National Hospital. Patients with CKD should undergo serial assessment of phosphate, calcium and parathyroid hormone level, considered together, so as to diagnose metabolic bone disease early and treat those patients who will be found to have persistently or prolonged abnormalities in these bone mineral biomarkers.
Mitotic arrest affects clustering of tumor cells
Authors: Bonnet Julia , Rigal Lise , Mondesert Odile , Morin Renaud , Corsaut Gaelle , Vigneau Mathieu , Ducommun Bernard , Lobjois Valerie 
Published: July 2020

Abstract
BackgroundCancer cell aggregation is a key process involved in the formation of tumor cells clusters. It has recently been shown that clusters of circulating tumor cells (CTCs) have an increased metastatic potential compared to isolated circulating tumor cells. Several widely used chemotherapeutic agents that target the cytoskeleton microtubules and cause cell cycle arrest at mitosis have been reported to modulate the number of CTCs or the size of CTC clusters.ResultsIn this study, we investigated in vitro the impact of mitotic arrest on the ability of breast tumor cells to form clusters. By using live imaging and quantitative image analysis, we found that MCF-7 cancer cell aggregation is compromised upon incubation with paclitaxel or vinorelbine, two chemotherapeutic drugs that target microtubules. In line with these results, we found that MCF-7 breast cancer cells experimentally synchronized and blocked in metaphase aggregated poorly with strongly reduced cohesion. To monitor clustering at the single-cell scale, we next developed and validated an in vitro assay based on live video-microscopy and custom-designed micro-devices. The study of cluster formation from MCF-7 cells that express the fluorescent marker LifeAct-mCherry using this new assay allowed showing that substrate anchorage-independent clustering of MCF-7 cells was associated with the formation of actin-dependent highly dynamic cell protrusions. Metaphase-synchronized and blocked cells did not display such protrusions, and formed very loose clusters that failed to compact.ConclusionsAltogether, our results suggest that mitotic arrest induced by microtubule-targeting anticancer drugs prevents cancer cell clustering and therefore, could reduce the metastatic potential of circulating tumor cells.
Resistance Development to Diflubenzuron and Bacillus Thuringiensis Subsp. Israelensis of Culex Pipiens f. Pipiens and Culex Pipiens f. Molestus (Diptera: Culicidae) and its Effects on Their Winter Survival
Authors: Ioannou Charalampos , Hadjichristodoulou Christos , Kyritsi Maria A. , Papadopoulos Nikos T. 
Published: July 2020

Abstract
Background: The Culex pipiens mosquito consists of two forms named pipiens and molestus that exhibit substantial differences in their biology including overwintering behavior. Diflubenzuron (DFB) and Bacillus thuringiensis subsp. israelensis (Bti) are among the most widely used larvicides for controlling Cx. pipiens populations. The high dependency on these two larvicides, pose major concerns for resistance development. The evolution and stability of resistance to insecticides has been associated with fitness costs that may be manifested under stressful conditions such as the winter period. The aim of the present study was to explore the resistance development of pipiens and molestus forms to both larvicides and its potential fitness costs on their winter survival.Methods: Colonies of both forms of Cx. pipiens were established from the same area. Following the World Health Organization protocols (WHO), the efficacy of both larvicides was determined for each mosquito population. Then, larvae from each form were selected for three successive generations by applying fixed doses corresponding to IE80 (IE: Inhibition of adult Emergence) and LC80 (LC: Lethal Concentration) for DFB and Bti respectively. At the end of this process, the resistance levels and the winter survival of the selected populations relative to controls (colonies that received no selection) were determined.Results: Contrary to Bti, selection with DFB induced different levels of resistance between the two forms of Cx. pipiens. The selected populations of Cx. pipiens f. molestus to both larvicides exhibited a high fitness cost in terms of reduced winter larval survival rates relative to control. Moreover, the obtained adults of the Bti selected population experienced significantly shorter lifespan compared to control and DFB selected population. On the other hand, selection with both DFB and Bti had no apparent effects on Cx. pipiens f. pipiens female winter survival rates relative to control. Furthermore, the reproductive parameters and the longevity of the overwintered females were similar between the selected populations and the control. Conclusions: Our findings are expected to contribute on the better understanding of the resistance development and evolution of the two forms of Cx. pipiens to DFB and Bti allowing the adoption of appropriate resistance management strategies.
Prenatal exposure to consumer product chemical mixtures and size for gestational age at delivery
Authors: Bommarito Paige A , Welch Barrett M. , Keil Alexander P , Baker George P , Cantonwine Dave E , McElrath Thomas F , Ferguson Kelly K. 
Published: July 2020

Abstract
Background

While fetal growth is a tightly regulated process, it is sensitive to environmental exposures that occur during pregnancy. Many commonly used consumer products contain chemicals that can disturb processes underlying fetal growth. However, mixtures of these chemicals have been minimally examined. We investigated associations between prenatal exposure to 33 consumer product chemicals (nine organophosphate ester flame retardant [OPE] metabolites, 12 phthalate metabolites, and 12 phenols) and the odds of small- or large-for-gestational age (SGA and LGA) births.
Methods

This case-control study was comprised of SGA (N = 31), LGA (N = 28), and appropriate for gestational age control (N = 31) births selected from the larger LIFECODES cohort. Biomarkers of exposure to consumer product chemicals were quantified in maternal urine collected from up to three study visits during pregnancy. In a single-pollutant approach, odds ratios (OR) and 95% confidence intervals (CI) of SGA and LGA associated with an interquartile range (IQR)-increase in exposure biomarkers were estimated using multinomial logistic regression. In a multi-pollutant approach, quantile g-computation was used to jointly estimate the OR (95% CI) of SGA and LGA per simultaneous one quartile-change in all biomarkers belonging to each chemical class.
Results

Among the 33 biomarkers analyzed, 20 were detected in at least 50% of the participants. After adjusting for potential confounders, we observed reduced odds of LGA in association with higher urinary concentrations of several exposure biomarkers. For example, an IQR-increase in the OPE metabolite, diphenyl phosphate, was associated with lower odds of LGA births (OR: 0.40 [95% CI: 0.18, 0.87]). Using quantile g-computation, we estimated lower odds of an LGA birth for lower OPE metabolites (OR: 0.49 [95% CI: 0.27, 0.89]) and phthalate metabolites (OR: 0.23 [95% CI: 0.07, 0.73]). Associations between consumer product chemicals and SGA were largely null.
Conclusions

Joint exposure to OPEs and phthalates was associated with lower odds of delivering LGA. Associations with LGA could indicate a specific impact of these exposures on the high end of the birth weight spectrum. Future work to understand this nuance in the associations between consumer product chemical mixtures and fetal growth is warranted.
Renal cell carcinoma with a pelvicalyceal system tumor thrombus: a case report
Authors: Li Jia-kuan , Liu Xiao-yong , Chen Rui , Chao Lu , Xiang Yu , Cui Zhi-gang , Song Xiao-tong , Han Wen-tao , Qi Heng-zhi , Wu Ji-hua , Shi Lei , Liu Gang 
Published: July 2020

Abstract
Background Renal cell carcinoma (RCCs) is the most common malignancy of the kidney. When RCC progresses, it is known to form tumor thrombus in the renal vein and/or inferior vena cava. However, RCC does not normally form tumor thrombus in the pelvicalyceal system. Case presentation A 56-year-old man presented to our department for the treatment of a renal tumor with asymptomatic gross hematuria. In a dynamic CT study, contrast enhancement revealed a tumor suspected to be RCC, but atypical finding as a tumor thrombus that filled the pelvicalyceal system was also observed. Nephroureterectomy was performed, and the tumor was diagnosed histopathologically as clear cell RCC and papillary RCC. Conclusion We report a rare case of RCC directly invading the pelvicalyceal system as a thrombus mass, with no microscopic individual tumor implants in the pelvicalyceal system wall, invasion of the renal vein, or invasion of adjacent organs. To our knowledge, only six such cases have been reported in English literature, and as a result, very few theories explaining pelvicalyceal system invasion have been presented. This highlights the signiﬁcance of adding invasion of the pelvicalyceal system as part of the most recent, updated tumor metastases classiﬁcation.
Impact of a Model Used to Simulate Socio-Environmental Stressors Encountered During Spaceflight on Murine Intestinal Microbiota
Authors: Alauzet Corentine , Cunat Lisiane , Wack Maxime , Lanfumey Laurence , Legrand-Frossi Christine , Lozniewski Alain , Agrinier Nelly , Cailliez-Grimal Catherine , Frippiat Jean-Pol 
Published: July 2020

Abstract
Background: During deep-space travels, crewmembers face various physical and psychosocial stressors that could alter gut microbiota composition. Since it is well known that intestinal dysbiosis is involved in the onset or exacerbation of several disorders, the aim of this study was to evaluate changes in intestinal microbiota in a ground-based murine model mimicking psychosocial stressors encountered during a long-term space mission.Results: We demonstrate that 3 weeks of exposure to Chronic Unpredictable Mild Stress (CUMS) induce significant change in intracaecal β-diversity characterized by an important increase of the Firmicutes/Bacteroidetes ratio. These stress-induced alterations are associated with a decrease of Porphyromonadaceae, particularly of the genus Barnesiella that is a major member of gut microbiota in mice, but also in human, where it is described as having protective properties.Conclusions: These results raise the question of the impact of stress-induced decrease of beneficial taxa, support recent data obtained with in-flight experimentations or gravity change models, and emphasize the critical need for further studies exploring the impact of spaceflight on intestinal microbiota in order to propose strategies to countermeasure spaceflight-associated dysbiosis and its consequences on health.