bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing structured mix and random rotation procedures to teach receptive labeling to children with autism
Authors: DiSanti Brittany M. , Eikeseth Svein , Eldevik Sigmund , Conrad Jenna M. , Cotter‐Fisher Kortnie L. 
Published: November 2019

ABSTRACTWe compared two procedures using an alternating treatments design to teach receptive labeling to children with autism. The structured mix procedure followed seven steps entailing mass trials, intermixing, and random rotation. In the random rotation procedure, we trained all stimuli from the start. Study 1 included four children with a repertoire of four to 50 receptive labels and who primarily communicated with an alternative communication device. Results showed that the two conditions were comparable for one participant, structured mix was effective and random rotation was not effective for one participant, and that both conditions were ineffective for two participants. Study 2 included five children with over 200 receptive labels in their repertoire and with vocal speech as the primary form of communication. Four participants acquired the labels in both procedures, but random rotation was more effective. Results indicate that structured mix may be more effective for participants with a limited language repertoire and random rotation is more effective for participants with a larger language repertoire.
Varying effects of tyrosine kinase inhibitors on platelet function—A need for individualized CML treatment to minimize the risk for hemostatic and thrombotic complications?
Authors: Deb Suryyani , Boknäs Niklas , Sjöström Clara , Tharmakulanathan Anjana , Lotfi Kourosh , Ramström Sofia 
Published: November 2019

AbstractSince their introduction, tyrosine kinase inhibitors (TKIs, eg, imatinib, nilotinib, dasatinib, bosutinib, ponatinib) have revolutionized the treatment of chronic myeloid leukemia (CML). However, long‐term treatment with TKIs is associated with serious adverse events including both bleeding and thromboembolism. Experimental studies have shown that TKIs can cause platelet dysfunction. Herein, we present the first side‐by‐side investigation comparing the effects of currently used TKIs on platelet function and thrombin generation when used in clinically relevant concentrations. A flow cytometry multiparameter protocol was used to study a range of significant platelet activation events (fibrinogen receptor activation, alpha granule, and lysosomal exocytosis, procoagulant membrane exposure, and mitochondrial permeability changes). In addition, thrombin generation was measured in the presence of TKIs to assess the effects on global hemostasis. Results show that dasatinib generally inhibited platelet function, while bosutinib, nilotinib, and ponatinib showed less consistent effects. In addition to these general trends for each TKI, we observed a large degree of interindividual variability in the effects of the different TKIs. Interindividual variation was also observed when blood from CML patients was studied ex vivo with whole blood platelet aggregometry, free oscillation rheometry (FOR), and flow cytometry. Based on the donor responses in the side‐by‐side TKI study, a TKI sensitivity map was developed. We propose that such a sensitivity map could potentially become a valuable tool to help in decision‐making regarding the choice of suitable TKIs for a CML patient with a history of bleeding or atherothrombotic disease.
Intensive Transactional Analysis Psychotherapy (ITAP): A case series study
Authors: Messina Irene , Scottà Francesco , Benelli Enrico , Marchi Arianna , Sambin Marco 
Published: November 2019

AbstractIntensive Transactional Analysis Psychotherapy (ITAP) is a new therapeutic approach based on the integration of Transactional Analysis and brief psychodynamic approaches. ITAP is based on two key therapeutic tools—the intrapsychic triangle and the interpersonal triangle—which the therapist uses to focus patients’ attention on moment‐by‐moment therapy processes. The aim of the present study was to provide early empirical documentation of ITAP effectiveness. To this aim, six patients (four females, two males) were longitudinally evaluated using an A‐B‐A mixed quantitative and qualitative design, with evaluations at Baseline, Treatment and Follow‐up phases. Each patient received 16 50‐min weekly sessions of ITAP therapy over 4 months. For quantitative evaluations, patients filled out the Clinical Outcome in Routine Evaluation‐Outcome Measure (CORE‐OM) at each evaluation. Effects size values were estimated to evaluate quantitative changes comparing mean scores of Baseline, Treatment and Follow‐up phases. At the first follow‐up, the Change Interview was used to qualitatively evaluate patients’ perceived changes. In the quantitative data, four of the six patients reported a very good outcome, with large to very large effect sizes in Baseline versus Treatment and/or Baseline versus Follow‐up scores comparisons, whereas two patients reported variable fluctuations within the non‐clinical range of outcome scores. In the qualitative evaluations, all patients reported several moderately to extremely important perceived changes attributed to psychotherapy.
When motivation is not enough: Effects of prosociality and organizational socialization in volunteers’ intention to continue volunteering
Authors: Livi Stefano , De Cristofaro Valeria , Theodorou Annalisa , Rullo Marika , Piccioli Valerio , Pozzi Maura 
Published: November 2019

AbstractRetention of volunteers is a main issue for no‐profit organizations. In the present study, using a cross‐sectional design, determinants of volunteers’ intentions to continue their service were investigated in a sample of 116 volunteers at different Italian organizations (Mage = 42.32, SDage = 15.91). Guided by the conceptual model of the volunteer process, we hypothesized that organizational socialization should mediate the link between prosocial personality and intention to continue volunteering. Results confirmed our prediction. Findings provide suggestions for organizations concerned about volunteers’ dropout that focus on ameliorating the socialization process of less prosocial volunteers in order to support their intention to remain in the organization.
Chemical Composition and in Vitro Cytotoxic Screening of Sixteen Commercial Essential Oils on Five Cancer Cell Lines
Authors: Najar Basma , Shortrede Jorge Eduardo , Pistelli Luisa , Buhagiar Joseph 
Published: November 2019

AbstractThe in vitro cytotoxic activity on human cancer cell lines of sixteen commercial EOs such as Aloysia citriodora, Boswellia sacra, Boswellia serrata, Cinnamomum zeylanicum, Cistus ladanifer, Citrus × aurantium, Citrus limon, Citrus sinensis, Cymbopogon citratus, Foeniculum vulgare, Illicium verum, Litsea cubeba, Satureja montana, Syzygium aromaticum, Thymus capitatus and Thymus vulgaris was performed using the MTT reduction assay. The screening was carried out on human cancer cells of breast adenocarcinoma (MCF7, T47D and MDA‐MB‐231), chronic myelogenous erythroleukemia (K562) and neuroblastoma cell lines (SH‐SY5Y). C. zeylanicum and L. cubeba EOs were the most active on almost all the cell lines studied and thus could be promising as an anticancer agent. These two species showed a difference in their composition even though they belong to the Lauraceae family. Almost 57 % of the true cinnamon composition was made of (E)‐cinnamaldehyde, while L. cubeba showed citral as the major compound (68.9 %). The K562 cells were the most sensitive to these oils with an IC50 ranging from 5.2 parts‐per million (ppm) (C. zeylanicum) to 11.1 ppm (L. cubeba). The latter oil also showed an important cytotoxicity on MDA‐MB‐231 (13.4 ppm).
Initial experience of a self‐expanding transcatheter aortic valve with an outer pericardial wrap: The United Kingdom and Ireland Implanters' registry
Authors: Dowling Cameron , Firoozi Sami , Panoulas Vasileios , Dalby Miles , Kashyap Mavin N. , Kabir Tito , Kalogeras Konstantinos , Buch Mamta H. , Levy Richard , Chowdhary Saqib , Saraf Smriti , Roberts David , More Ranjit , Wiper Andrew , Abdelaziz Hesham K. , Neylon Antoinette , Mylotte Darren , Pisaniello Anthony D. , Fraser Douglas G. W. , Anderson Richard , Cunnington Michael S. , Malkin Christopher J. , Blackman Daniel J. , Brennan Paul F. , Owens Colum G. , Manoharan Ganesh , Spence Mark S. , Brecker Stephen J. 
Published: November 2019

AbstractObjectivesThe United Kingdom and Ireland Implanters' registry is a multicenter registry which reports on real‐world experience with new transcatheter heart valves.BackgroundThe Evolut PRO (Medtronic, Minneapolis, MN) transcatheter aortic valve is a self‐expanding transcatheter aortic valve with an outer pericardial wrap, designed to minimize paravalvular regurgitation.MethodsBetween July 2017 and December 2018, clinical, procedural, and 30‐day outcome data were prospectively collected from all patients receiving the Evolut PRO valve across nine participating centers in the United Kingdom and Ireland. The primary efficacy outcome was the Valve Academic Research Consortium‐2 (VARC‐2)‐defined endpoint of device success. The primary safety outcome was the VARC‐2‐defined composite endpoint of early safety at 30 days.ResultsA total of 317 patients underwent implantation. Mean age was 81.8 ± 6.4 years and Society of Thoracic Surgeons Predicted Risk of Mortality Score 5.5 ± 1.8%. Iliofemoral access was used in 99.1% of patients. Device success was 91.2%. Mean gradient was 7.6 ± 4.7 mmHg and effective orifice area 1.9 ± 0.7 cm2. The incidence of moderate paravalvular regurgitation was 1.7% and there was no severe paravalvular regurgitation. A new permanent pacemaker was implanted in 17.8% of patients without a pacemaker at baseline. Early safety was demonstrated in 92.7%. At 30 days, all‐cause mortality was 0.6%, stroke 3.8%, and major vascular complication 2.8%.ConclusionsReal‐world experience of the Evolut PRO transcatheter aortic valve demonstrated favorable procedural success, safety, valve function, and incidence of new permanent pacemaker implantation.
The utilization of single versus double Perclose devices for transfemoral aortic valve replacement access site closure: Insights from Cleveland Clinic Aortic Valve Center
Authors: Bazarbashi Najdat , Ahuja Keerat , Gad Mohamed M. , Sammour Yasser M. , Kaur Manpreet , Karrthik Antonette , Saad Anas M. , Khubber Shameer , Dhaliwal Kamalpreet , Mick Stephanie L. , Navia Jose L. , Puri Rishi , Reed Grant W. , Krishnaswamy Amar , Kapadia Samir R. 
Published: November 2019

AbstractIntroductionPercutaneous femoral access is the preferred access route for transcatheter aortic valve replacement (TAVR). The majority of experienced TAVR centers use two 6F Perclose ProGlide™ devices to close the primary vascular access site, deployed prior to upsizing sheath size with closure completed at the end of the case (the “preclose” approach). A strategy of utilizing a single Perclose device to preclose may have advantages including fewer complications, complexity, and cost, but the safety of this is unknown. This study examines in the safety and efficacy of using a single Perclose versus double Perclose for perclosure of large bore access during TAVR.MethodsPatients undergoing Transfemoral (TF) TAVR from January 2014 to December 2017 within the Cleveland Clinic Aortic Valve Center were identified. A retrospective review of medical charts was conducted. Vascular complications were defined according to the VARC‐2 criteria.ResultsA total of 740 patients were included; 487 (65.8%) received a single Perclose device while 253 (34.2%) received double Perclose devices. Baseline characteristics were similar with no differences between the single versus double Perclose groups, respectively. The access sheath size was similar in both groups with (14, 16, and 18 F) being the most common sizes utilized. Of the total 487 patients with single Perclose, 75.6% needed additional closure device (AngioSeal). With double Perclose strategy, additional closure device (AngioSeal) was used in 40.3% patients with 470 (63.5%) patients being successfully perclosed. Vascular complication rates including hematoma, stenosis requiring stenting, pseudoaneurysm, and other major vascular complications were similar between both groups.ConclusionSingle 6F ProGlide use for preclosure is a safe strategy for TF TAVR using the S3 valve. Additional closure device was not needed in almost one‐quarter of the patients. When necessary, residual bleeding can be controlled with the AngioSeal Device at the end of the procedure. This single device preclose strategy can help to reduce the cost of TAVR procedure without increasing risk.
Evaluation of a novel mesh‐covered stent for treatment of carotid stenosis in patients at high risk for endarterectomy: 1‐year results of the SCAFFOLD trial
Authors: Gray William A. , Levy Elad , Bacharach J. Michael , Metzger David Christopher , Randall Bryan , Siddiqui Adnan , Schonholz Claudio , Alani Firas , Schneider Peter A. 
Published: November 2019

AbstractObjectiveThe SCAFFOLD trial evaluated the GORE® Carotid Stent (GCS), a novel, mesh‐covered device and evaluated outcomes at 1 year.BackgroundSCAFFOLD was a prospective, multicenter, single‐arm clinical trial in patients with severe carotid artery stenosis (angiographically defined as symptomatic ≥50% or asymptomatic ≥80%) at increased risk for adverse events from carotid endarterectomy. Interim 30‐day analysis demonstrated low rates of death/stroke/myocardial infarction (DSMI; 3.0%) and stroke (1.1%) in a high surgical risk population.MethodsThe rate of DSMI within 30 days plus ipsilateral stroke between 31 days and 1 year (primary endpoint) was compared to a predetermined performance goal. Secondary outcomes of freedom from clinically driven target lesion revascularization (CD‐TLR; diameter stenosis ≥80% by core lab angiography, or ≥50% with clinical symptoms) and restenosis (≥80% diameter stenosis by core lab angiography) are reported as Kaplan–Meier (KM) estimates.ResultsOf the 312 patients enrolled and treated, 264 were eligible per protocol and evaluable for major adverse events at 30 days, and 244 (92%) of these were evaluable at 1 year. The proportion of patients with DSMI at 1 year was 4.5% and was significantly lower than the prespecified performance goal of 16.9% (p < .00001). The proportion with ipsilateral stroke from 31 to 365 days was 1.2%. The KM estimates of 1‐year event probability were 1.6% for CD‐TLR and 1.2% for restenosis.ConclusionsUse of the mesh‐covered GCS in the SCAFFOLD trial demonstrated 100% technical success and low rates of both periprocedural and late stroke, with durable patency at 1 year.ClinicalTrials.gov Identifier: NCT01901874 (redacted).
Antegrade transcatheter closure of a dehiscence of pulmonary bioprosthesis after pulmonary valve replacement with the Occlutech paravalvular leak device
Authors: Godart François , Baudelet Jean‐Benoit , Soquet Jerome , Onorato Eustaquio 
Published: November 2019

AbstractWe report a case of antegrade transcatheter occlusion of a paravalvular leak (PVL) after bioprosthetic pulmonary valve replacement in a 31‐year‐old patient with tetralogy of Fallot. The leak resulted in severe pulmonary regurgitation with right ventricle volume overload. This case is the first‐ever report of a successful percutaneous closure of PVL using the Occlutech paravalvular leak device.
Temporal trends in the utilization and outcomes of percutaneous coronary interventions in patients with liver cirrhosis
Authors: Alqahtani Fahad , Balla Sudarashan , AlHajji Mohamed , Chaudhary Fahad , Albeiruti Ridwaan , Kawsara Akram , Alkhouli Mohamad 
Published: November 2019

AbstractObjectivesWe sought to assess the national trends in the utilization and outcomes of percutaneous coronary interventions (PCI) in patients with cirrhosis.BackgroundContemporary data on PCI in patients with liver cirrhosis are limited.MethodsThe National‐Inpatient‐Sample was used to identify patients who underwent PCI between 2003 and 2016. We examined the annual PCI rate, and compared the in‐hospital morbidity, mortality, resource utilization, and cost following PCI in patients with and without cirrhosis.ResultsA total of 8,860,178 PCI hospitalizations were identified, of those, 20,339 (0.2%) were performed in patients with cirrhosis. Annual PCI rates decreased overtime in patients without liver cirrhosis but increased in those with cirrhosis (Ptrend < .001). Patients with cirrhosis had a characteristic clinical, demographic, and socioeconomic profile compared with those without cirrhosis. The use of bare‐metal stents decreased from 69.1 to 11.4% in the noncirrhosis group, and from 81.9 to 21.3% in the cirrhosis group. Compared with propensity‐matched patients without cirrhosis, PCI in cirrhotic patients was associated with higher in‐hospital mortality across all indications (STEMI 19.1 vs. 11.5%, p = .002; NSTEMI 8.7 vs. 5.6%, p = .002; and UA/SIHD 7.7 vs. 4.3%, p < .001). Cirrhotic patients also had significantly higher rates of acute kidney injury, but similar rates of vascular complications and stroke. Additionally, cirrhotic patients had longer hospitalizations, were less likely to be discharged home, and accrued higher cost across all PCI indications.ConclusionsPatients with cirrhosis who are deemed “suitable PCI candidates” in current practice remain at high‐risk for worse short‐term morbidity and mortality, and higher cost of care.
Descriptors to Predict Dye‐Sensitized Semiconductor Based Photocatalyst for Hydrogen Evolution Reaction
Authors: Sappati Subrahmanyam , George Leena , Swamy Vincent Paul , Devi R. Nandini , Ghosh Prasenjit 
Published: November 2019

AbstractDiscovering efficient photocatalysts for hydrogen production from water splitting is highly desirable. Computational studies can help in rational designing of such catalysts through high throughput screening of materials. However, for that purpose one needs to identify descriptors that not only connects material properties with their functionality but are easy and inexpensive to compute. Using a combination of density functional theory based calculations and experiments we show two descriptors, namely, charge injection efficiency and electron hole separation, that can be used for in silico design of new and efficient dye‐sensitized‐semiconductor composites as catalysts for hydrogen evolution reaction.
Mechanism of Methanol‐to‐hydrocarbon Reaction over Zeolites: A solid‐state NMR Perspective
Authors: Wang Chao , Xu Jun , Deng Feng 
Published: November 2019

AbstractThe versatile methanol‐to‐hydrocarbon (MTH) process on acidic zeolites allows for a production of olefins, aromatics and gasoline from a wide range of non‐fossil resources. Elucidation of the MTH reaction mechanism is helpful to improve product selectivity as well as develop high performance catalysts. The application of solid‐state NMR in the investigation of MTH reaction has significantly contributed to get insight into the MTH chemistry. In this review, we summarize mechanistic insight that has been gained into the MTH reaction by using solid‐state NMR spectroscopy. Special emphasis is given to the observation and determination of C1 species and active intermediates particularly cyclic carbocations to uncover the exact reaction route for the initial C−C bond formation and the hydrocarbon pool mechanism. The detection of host‐guest interactions involved in the MTH reaction with the advanced 13C‐27Al double‐resonance NMR is discussed for a better understanding of the active sites and the reactivity of hydrocarbon pool species.
Luminescent Gold Nanorods To Enhance the Near‐Infrared Emission of a Photosensitizer for Targeted Cancer Imaging and Dual Therapy: Experimental and Theoretical Approach
Authors: Nair Resmi V. , Nair Lakshmi V. , Govindachar Divya Maldepalli , Santhakumar Hema , Nazeer Shaiju S. , Rekha Charuvil Radhakrishnapillai , Shenoy Sachin J. , Periyasamy Ganga , Jayasree Ramapurath S. 
Published: November 2019

AbstractStrong plasmon absorption in the near‐infrared (NIR) region renders gold nanorods (GNRs) amenable for biomedical applications, particularly for photothermal therapy. However, these nanostructures have not been explored for their imaging potential because of their weak emission profile. In this study, the weak fluorescence emission of GNRs is tuned to match that of the absorption of a photosensitizer (PS) molecule, and energy transfer from the GNR to PS enhances the emission profile of the GNR–PS combination. GNR complexes generally quench the fluorescence emission of nearby chromophores. However, herein, the complex retains or rather enhances the fluorescence through competition in energy transfer. Excitation‐dependent energy transfer has been explained experimentally and theoretically by using DFT calculations, the CIE chromaticity diagram, and power spectrum. The final GNR–PS complex modified for tumor specificity serves as an excellent organ‐specific theranostic probe for bioimaging and dual therapy both in vitro and in vivo. Principal component analysis designates photodynamic therapy a better candidate than that of photothermal therapy for long‐term efficacy in vivo.
The efficacy of a technology‐based information and coaching/support program on pain and symptoms in Asian American survivors of breast cancer
Authors: Im Eun‐Ok , Kim Sangmi , Yang You Lee , Chee Wonshik 
Published: November 2019

BackgroundPain is a common problem, especially in the first few years of breast cancer survivorship. Asian American survivors of breast cancer reportedly have inadequate cancer pain management, and subsequently report a lower quality of life compared with other racial/ethnic groups. Technology‐based programs could improve the cancer pain management process. The purpose of the current study was to examine the efficacy of a technology‐based information and coaching/support program on cancer pain and its accompanying symptoms among Asian American survivors of breast cancer.MethodsThe current study adopted a randomized pretest/posttest group design. The sample included 115 Asian American survivors of breast cancer (49 in the control group and 66 in the intervention group). The participants' background features, pain (frequency and distress), accompanying symptom distress (global, physical, and psychological), and 4 theory‐based mediators (attitude, self‐efficacy, perceived barriers, and social influence) were measured using multiple instruments at 3 time points (pretest, after 1 month, and after 3 months). The current study used an intent‐to‐treat approach and conducted linear mixed model growth curve analyses.ResultsThere were significant decreases noted in all outcome variables, including pain and symptoms over time in both groups. There were greater decreases in physical symptom distress scores among the intervention group compared with the control group (P = .0229). The mediators as a whole significantly explained overall decreases in general, physical, and psychological symptom distress scores after 3 months in both groups and the intervention group's greater decreases in general, physical, and psychological symptom distress scores after 1 month.ConclusionsThe technology‐based program described herein could help to reduce cancer pain and its accompanying symptoms among Asian American survivors of breast cancer.