bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of the Neuro-Immune-Vascular Plexus in the Ventricular Zone of the Prenatal Rat Neocortex
Authors: Penna Elisa , Mangum Jon M , Shepherd Hunter , Martínez-Cerdeño Veronica , Noctor Stephen C 
Published: October 2020

AbstractMicroglial cells make extensive contacts with neural precursor cells (NPCs) and affiliate with vasculature in the developing cerebral cortex. But how vasculature contributes to cortical histogenesis is not yet fully understood. To better understand functional roles of developing vasculature in the embryonic rat cerebral cortex, we investigated the temporal and spatial relationships between vessels, microglia, and NPCs in the ventricular zone. Our results show that endothelial cells in developing cortical vessels extend numerous fine processes that directly contact mitotic NPCs and microglia; that these processes protrude from vessel walls and are distinct from tip cell processes; and that microglia, NPCs, and vessels are highly interconnected near the ventricle. These findings demonstrate the complex environment in which NPCs are embedded in cortical proliferative zones and suggest that developing vasculature represents a source of signaling with the potential to broadly influence cortical development. In summary, cortical histogenesis arises from the interplay among NPCs, microglia, and developing vasculature. Thus, factors that impinge on any single component have the potential to change the trajectory of cortical development and increase susceptibility for altered neurodevelopmental outcomes.
Chemogenetics Reveal an Anterior Cingulate–Thalamic Pathway for Attending to Task-Relevant Information
Authors: Bubb Emma J , Aggleton John P , O’Mara Shane M , Nelson Andrew J D 
Published: October 2020

AbstractIn a changing environment, organisms need to decide when to select items that resemble previously rewarded stimuli and when it is best to switch to other stimulus types. Here, we used chemogenetic techniques to provide causal evidence that activity in the rodent anterior cingulate cortex and its efferents to the anterior thalamic nuclei modulate the ability to attend to reliable predictors of important outcomes. Rats completed an attentional set-shifting paradigm that first measures the ability to master serial discriminations involving a constant stimulus dimension that reliably predicts reinforcement (intradimensional-shift), followed by the ability to shift attention to a previously irrelevant class of stimuli when reinforcement contingencies change (extradimensional-shift). Chemogenetic disruption of the anterior cingulate cortex (Experiment 1) as well as selective disruption of anterior cingulate efferents to the anterior thalamic nuclei (Experiment 2) impaired intradimensional learning but facilitated 2 sets of extradimensional-shifts. This pattern of results signals the loss of a corticothalamic system for cognitive control that preferentially processes stimuli resembling those previously associated with reward. Previous studies highlight a separate medial prefrontal system that promotes the converse pattern, that is, switching to hitherto inconsistent predictors of reward when contingencies change. Competition between these 2 systems regulates cognitive flexibility and choice.
Strategic Narratives in Global Trade Politics: American Hegemony, Free Trade, and the Hidden Hand of the State
Authors: Hopewell Kristen 
Published: October 2020

Abstract
The characterization of the United States as a liberal hegemon seeking to uphold free-market capitalism against the illiberal state capitalism of China and other emerging powers has become commonplace, along with the attendant notion that American economic openness has been exploited by the unfair trade practices of other states. Given their dominance in US political discourse and role in shaping contemporary policy—including fuelling Trump’s trade wars and aggressive unilateral trade actions against all of the United States’ major trading partners, his attacks on the World Trade Organization, and talk of a “new Cold War” between the United States and China—these claims merit far greater scrutiny. In this article, I challenge the stark dichotomy frequently drawn between American “free-market capitalism” and the “state capitalism” of its emerging challengers, arguing that this forms part of a strategic narrative deployed for political purposes, including legitimating the United States’ use of aggressive trade policy measures. An examination of the American hegemon’s actual trade and industrial policies complicates this characterization. Despite presenting itself as a promoter and defender of free trade, I show that the unifying logic of US trade policy has always been the promotion of American economic interests: the United States has engaged in considerable state intervention and trade protectionism, both to shield vulnerable industries and support others to achieve and maintain their global dominance.
Heart regeneration: beyond new muscle and vessels
Authors: Sayers Judy R , Riley Paul R 
Published: October 2020

AbstractThe most striking consequence of a heart attack is the loss of billions of heart muscle cells, alongside damage to the associated vasculature. The lost cardiovascular tissue is replaced by scar formation, which is non-functional and results in pathological remodelling of the heart and ultimately heart failure. It is, therefore, unsurprising that the heart regeneration field has centred efforts to generate new muscle and blood vessels through targeting cardiomyocyte proliferation and angiogenesis following injury. However, combined insights from embryological studies and regenerative models, alongside the adoption of -omics technology, highlight the extensive heterogeneity of cell types within the forming or re-forming heart and the significant crosstalk arising from non-muscle and non-vessel cells. In this review, we focus on the roles of fibroblasts, immune, conduction system, and nervous system cell populations during heart development and we consider the latest evidence supporting a function for these diverse lineages in contributing to regeneration following heart injury. We suggest that the emerging picture of neurologically, immunologically, and electrically coupled cell function calls for a wider-ranging combinatorial approach to heart regeneration.
Empirical formula for the quality factors of crack resonances and its application to the estimation of source properties of long-period seismic events at active volcanoes
Authors: Taguchi Kimiko , Kumagai Hiroyuki , Maeda Yuta , Torres Roberto 
Published: October 2020

SUMMARYLong-period (LP) seismic events at active volcanoes are thought to be generated by oscillations of fluid-filled resonators. The resonator geometry and fluid properties of LP sources have been estimated by comparing observed frequencies and quality factors (Q) with those calculated by numerical simulations with a crack model. A method to estimate all the parameters of crack geometry and fluid properties using an analytical formula for crack resonance frequencies has recently been proposed, but this method requires long computational times to compare observed and simulated Q values, especially for LP events with large Q. To resolve this problem, we used numerical simulations to systematically investigate the empirical relation between Q and crack model parameters. We found that Q can be calculated with an empirical formula expressed by the crack width-to-length ratio and the ratio of P-wave velocity in the solid medium to sound speed in the fluid. We applied this formula to LP events at Kusatsu–Shirane volcano, Japan, between 1992 August and 1993 January and at Galeras volcano, Colombia, in 1993 January. Assuming misty gas as the fluid in the crack at Kusatsu–Shirane and dusty gas as the fluid at Galeras, the empirical formula provided more detailed estimates of the parameters than those obtained previously using the Q values estimated in numerical simulations. We then applied the empirical formula to LP events with large Q values observed at Galeras between 2006 December and 2007 January. When we assumed dusty gas as the fluid in the crack, we found decreasing trends in both crack volume and the gas-weight fraction of water vapour in the crack. We also found that the dust volume was proportionally related to the product of crack aperture and crack length or width. These trends and relations were similar to those in 1993 January, suggesting that the LP events at Galeras between 2006 and 2007 were triggered by the explosive fragmentation of intruded magma and the production of a dusty gas, as was previously inferred for the LP events in 1993 January. Welding of ash in the dusty gas and dense magma remaining in the conduit after fragmentation led to a decrease in the source crack size prior to the next LP event. These results demonstrate that our empirical formula for Q can be used to estimate the source properties of LP events with large Q values without requiring long computational times. Use of the formula may thus contribute to improved monitoring of fluid states and understanding of LP triggering processes beneath many volcanoes.
Geographical Indications: A Major Challenge for MERCOSUR
Authors: Blasetti Roxana 
Published: October 2020

Abstract
This article focuses on the intellectual property chapter of the EU-MERCOSUR Free Trade Agreement. It is not intended to provide an exhaustive analysis of all the intellectual property rights involved but to go deeply into a specific matter, geographical indications, which is undoubtedly a controversial concession in the chapter.
The entire free trade agreement negotiations took more than 20 years and ended in June 2019 with an ‘Agreement in principle’. From the very beginning it involved a red line for the MERCOSUR countries, namely the intellectual property chapter.
This article will show the complexity of including the private rights of prior users (generic names, plant varieties and trademarks) as a trade-off for agricultural market access in negotiations mainly focused on tariff reduction and trade rules.
In addition, the imbalance between the parties was deepened by the lack of regionally harmonized intellectual property standards within MERCOSUR.
In this regard, the main objective of this article is to identify the legal challenges derived from the overlap of national, regional and bi-regional rules that the Mercosur countries will face when implementing the geographical indication commitments, given the bloc’s legal and institutional structure. Unlike tariff reduction, the commitments derived from the negotiation of private rights are a crucial issue. Against this background, some proposals are outlined to address how to determine a medium- and long-term strategy based on the needs of local producers to add value to their productions.
Comparison of early postoperative cytokine changes in patients undergoing intubated and non-intubated thoracic surgery: a randomized controlled trial
Authors: Jeon Joonpyo , Sung Sookwhan , Moon Youngkyu , Koo Jungmin , Hyun Kwanyong , Han Kyungdo , Hwang Wonjung 
Published: October 2020

Abstract

OBJECTIVES
The inflammatory response after surgery is associated with patient prognosis. Patients who undergo thoracic surgery exhibit a profound systemic inflammatory response due to the surgical procedures used and application of one-lung ventilation. The aim of this study was to compare perioperative inflammatory changes in patients after intubated and non-intubated thoracic surgery for primary lung cancer resection.

METHODS
This prospective randomized controlled study included forty patients who underwent surgical resection for stage I non-small-cell lung cancer. Blood samples for cytokine analysis were collected just before induction, at 1 and 24 h after surgery. Levels of the pro-inflammatory cytokine and anti-inflammatory cytokines were measured using quantitative sandwich enzyme immunoassay kits.

RESULTS
The basal values of cytokines were comparable between 2 groups. Within each group, the postoperative levels of interleukin (IL)-1, IL-6 and tumour necrosis factor-α increased, while those of IL-4 and IL-10 did not change significantly. The levels of IL-6 and tumour necrosis factor-α were significantly lower in group NI at 1 and 24 h postoperatively. Other cytokines did not differ in both groups during postoperative period. The IL-6/IL-10 ratio at 1 h after surgery was lower in non-intubated patients than in intubated patients, but there was no difference at 24 h after surgery

CONCLUSIONS
Non-intubated thoracic surgery may attenuate the early inflammatory cytokine changes following major resection for primary lung cancer compared with intubated conventional surgery.

Clinical trial registration
ClinicalTrials.gov registry number NCT04007354
Can public access to documents support the transparency of automated decision-making? The European Union law perspective
Authors: Mazur Joanna 
Published: October 2020

ABSTRACT
Due to the concerns which are raised regarding the impact of automated decision-making (ADM) on transparency and their potential discriminatory character, it is worth examining the possibility of applying legal measures which could serve to increase transparency of ADM systems. The article explores the possibility to consider algorithms used in ADM systems as documents subjected to the right to access documents in European Union (EU) law. It is focused on contrasting and comparing the approach based on the right to access public documents developed by the Court of Justice of European Union (CJEU) with the approach to the right to access public information as interpreted by the European Court of Human Rights (ECtHR). The analysis shows discrepancies in the perspectives presented by these Courts which result in a limited scope of the right to access public documents in EU law. Pointing out these differences may provide a motivation to clarify the meaning of the right to access information in EU law, the CJEU’s approach remaining as for now incoherent. The article presents the arguments for and ways of bringing together the approaches of the CJEU and the ECtHR in the light of a decreasing level of transparency resulting from the use of ADM in the public sector. It shows that in order to ensure compliance with EU law, it is necessary to rethink the role which the right to access information plays in the human rights catalogue.
Design and development of Referrals Automation, a SMART on FHIR solution to improve patient access to specialty care
Authors: Odisho Anobel Y , Lui Hansen , Yerramsetty Ramakrishna , Bautista Felicisimo , Gleason Nathaniel , Martin Edwin , Young Jerry J , Blum Michael , Neinstein Aaron B 
Published: October 2020

Abstract

Background
Referring patients to specialty care is an inefficient and error-prone process. Gaps in the referral process lead to delays in patients’ access to care, negative patient experience, worse health outcomes, and increased operational costs. While implementation of standards-based electronic referral options can alleviate some of these inefficiencies, many referrals to tertiary and quaternary care centers continue to be sent via fax.

Objective
We describe the design process and architecture for a software application that has been developed and deployed to optimize the referrals intake process by automating the processing and digitization of incoming specialty referral faxes, extracting key data elements and integrating them into the electronic health record (EHR), and organizing referrals.

Methods
A human-centered design approach was used to identify and describe the inefficiencies in the external referral process at our large, urban tertiary care center. Referrals Automation, an application to convert referral faxes to digital referrals in the EHR, was conceptualized based on key stakeholder interviews and time and motion studies. This application was designed using Substitutable Medical Applications and Reusable Technologies (SMART) and Fast Healthcare Interoperability Resource (FHIR) platforms to allow for adaptability into other healthcare organizations.

Results
Referrals Automation software was developed as a healthcare information technology solution to streamline the fax to referral process. The application was implemented into several specialty clinics. Metrics were built-in to the applications to evaluate and guide the further iteration of these features.

Conclusions
Referrals Automation will enhance the referrals process by further streamlining and organizing the patient referral process.
A geometric deep learning approach for checking element-to-entity mappings in infrastructure building information models
Authors: Koo Bonsang , Jung Raekyu , Yu Youngsu , Kim Inhan 
Published: October 2020

Abstract
Data interoperability between domain-specific applications is a key prerequisite for building information modeling (BIM) to solidify its position as a central medium for collaboration and information sharing in the construction industry. The Industry Foundation Classes (IFC) provides an open and neutral data format to standardize data exchanges in BIM, but is often exposed to data loss and misclassifications. Concretely, errors in mappings between BIM elements and IFC entities may occur due to manual omissions or the lack of awareness of the IFC schema itself, which is broadly defined and highly complex. This study explored the use of geometric deep learning models to classify infrastructure BIM elements, with the ultimate goal of automating the prechecking of BIM-to-IFC mappings. Two models with proven classification performance, Multi-View Convolutional Neural Network (MVCNN) and PointNet, were trained and tested to classify 10 types of commonly used BIM elements in road infrastructure, using a dataset of 1496 3D models. Results revealed MVCNN as the superior model with ACC and F1 score values of 0.98 and 0.98, compared with PointNet's corresponding values of 0.83 and 0.87, respectively. MVCNN, which employs multiple images to learn the features of a 3D artifact, was able to discern subtle differences in their shapes and geometry. PointNet seems to lose the granularity of the shapes, as it uses points partially selected from point clouds.
Probing the cluster pressure profile with thermal Sunyaev–Zeldovich effect and weak lensing cross-correlation
Authors: Ma Yin-Zhe , Gong Yan , Tröster Tilman , Van Waerbeke Ludovic 
Published: October 2020

ABSTRACT
We confront the universal pressure profile (UPP) proposed. with the recent measurement of the cross-correlation function of the thermal Sunyaev–Zeldovich (tSZ) effect from Planck and weak gravitational lensing measurement from the Red Cluster Sequence Lensing Survey. By using the halo model, we calculate the prediction of ξy−κ (lensing convergence and Compton-y parameter) and $\xi ^{y-\gamma _{\rm t}}$ (lensing shear and Compton-y parameter) and fit the UPP parameters by using the observational data. We find consistent UPP parameters when fixing the cosmology to either WMAP 9-yr or Planck 2018 best-fitting values. The best constrained parameter is the pressure profile concentration c500 = r500/rs, for which we find $c_{500} = 2.68^{+1.46}_{-0.96}$ (WMAP-9) and $c_{500} = 1.91^{+1.07}_{-0.65}$ (Planck-2018) for the $\xi ^{y-\gamma _t}$ estimator. The shape index for the intermediate radius region α parameter is constrained to $\alpha =1.75^{+1.29}_{-0.77}$ and $\alpha = 1.65^{+0.74}_{-0.5}$ for WMAP-9 and Planck-2018 cosmologies, respectively. Propagating the uncertainties of the UPP parameters to pressure profiles results in a factor of 3 uncertainty in the shape and magnitude. Further investigation shows that most of the signal of the cross-correlation comes from the low-redshift, inner halo profile (r ≤ rvir/2) with halo mass in the range of 1014–$10^{15}{\, {\rm M}_{\odot }}$, suggesting that this is the major regime that constitutes the cross-correlation signal between weak lensing and tSZ.
The [O iii]+H β equivalent width distribution at z ≃ 7: implications for the contribution of galaxies to reionization
Authors: Endsley Ryan , Stark Daniel P , Chevallard Jacopo , Charlot Stéphane 
Published: October 2020

ABSTRACT
We quantify the distribution of [O iii]+H β line strengths at z ≃ 7 using a sample of 20 bright ($\mathrm{M}_{\mathrm{UV}}^{}$ ≲ –21) galaxies. We select these systems over wide-area fields (2.3 deg2 total) using a new colour-selection that precisely selects galaxies at z ≃ 6.63–6.83, a redshift range where blue Spitzer/IRAC [3.6]−[4.5] colours unambiguously indicate strong [O iii]+H β emission. These 20 galaxies suggest a lognormal [O iii]+H β EW distribution with median EW = 759$^{+112}_{-113}$ Å and standard deviation = 0.26$^{+0.06}_{-0.05}$ dex. We find no evidence for strong variation in this EW distribution with UV luminosity. The typical [O iii]+H β EW at z ≃ 7 implied by our sample is considerably larger than that in massive star-forming galaxies at z ≃ 2, consistent with a shift towards larger average sSFR (4.4 Gyr−1) and lower metallicities (0.16 Z⊙). We also find evidence for the emergence of a population with yet more extreme nebular emission ([O iii]+H β EW &gt; 1200 Å) that is rarely seen at lower redshifts. These objects have extremely large sSFR (&gt;30 Gyr−1), as would be expected for systems undergoing a burst or upturn in star formation. While this may be a short-lived phase, our results suggest that 20 per cent of the z ≃ 7 population has such extreme nebular emission, implying that galaxies likely undergo intense star formation episodes regularly at z &gt; 6. We argue that this population may be among the most effective ionizing agents in the reionization era, both in terms of photon production efficiency and escape fraction. We furthermore suggest that galaxies passing through this large sSFR phase are likely to be very efficient in forming bound star clusters.
On the torque reversals of accreting neutron stars
Authors: Ertan Ünal 
Published: October 2020

ABSTRACT
We have extended the analytical model proposed earlier to estimate the inner disc radius of accreting neutron stars in the strong-propeller (SP) phase, and the conditions for the transitions between the strong and weak propeller (WP) phases (Ertan 2017, 2018) to the WP (accretion with spin-down) and the spin-up (SU) phases, and the torque reversals during the WP/SU transitions. The model can account for some basic observed properties of these systems that are not expected in conventional models: (1) accretion on to the star at low X-ray luminosities and the transitions to the SP phase (no accretion) at critical accretion rates much lower than the rate required for the spin-up/spin-down transition, (2) ongoing accretion throughout a large range of accretion rates while the source is spinning down (WP phase), and (3) transitions between the spin-up and spin-down phases with comparable torque magnitudes, without substantial changes in the mass-flow rate. Our results indicate that the magnitudes of the torques on either side of the torque reversal have a ratio similar for different systems independently of their spin periods, magnetic dipole moments, and accretion rates during the transitions. Estimated torque reversal properties in our model are in agreement with the observed torque reversals of 4U 1626–67.