bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synovial fluid dual‐biomarker algorithm accurately differentiates osteoarthritis from inflammatory arthritis
Authors: Keter Daniel , Thai‐Paquette Van , Miamidian John , Gulati Simmi , Toler Krista 
Published: December 2024

AbstractOsteoarthritis (OA) prevalence increases as the population ages. Diagnosing osteoarthritis often occurs in the late stages when cartilage degradation is severe, making it difficult to distinguish from other types of arthritis. Accurate differentiation of primary osteoarthritis from other arthritic conditions is crucial for effective treatment planning. A new diagnostic test has been developed that uses a dual‐biomarker algorithm to inform osteoarthritis diagnosis. Synovial fluid from patients with confirmed primary osteoarthritis showed elevated levels of cartilage oligomeric matrix protein. However, this biomarker alone could not distinguish primary osteoarthritis from other inflammatory conditions that also cause cartilage deterioration. Therefore, a combinatorial algorithm using cartilage oligomeric matrix protein and Interleukin‐8 concentrations was developed to differentiate primary osteoarthritis from inflammatory arthritis. Clinical decision limits for cartilage oligomeric matrix protein concentration and the cartilage oligomeric matrix protein to Interleukin‐8 ratio were established and validated using 171 human knee synovial fluid specimens. The osteoarthritis algorithm demonstrated clinical sensitivity and specificity of 87.0% and 88.9%, respectively. This is the first report of a biomarker test that can differentiate primary osteoarthritis from inflammatory arthritis with a high degree of accuracy.
In Situ Forming Hypoxia‐Induced Exosome‐Loaded Hydrogel for Enhanced Diabetic Wound Healing
Authors: Wang Yong‐fei , Zhao Gang , A Sigen , Xu Qian , Wu Xiao‐li , Wang Wen‐Xin , Rui Yong‐jun 
Published: December 2024

AbstractDiabetic wound healing presents unique challenges, including impaired angiogenesis, prolonged inflammation, and delayed re‐epithelialization. Advancements in tissue engineering offer promising solutions through cell/drug‐based therapies. Exosomes (Exo) derived from hypoxia‐preconditioned adipose‐derived stem cells (ADSCs) have gained attention for their potential to address these complex issues in diabetic wounds. Existing strategies for Exo delivery aim to overcome drawbacks associated with conventional administration methods, including rapid loss of activity, frequent dosing, and off‐target effects. However, complexities in fabrication, undesirable components within the delivery system, and unforeseen outcomes have hindered the efficacy of these approaches. Thus, an in situ formed hydrogel is engineered using click chemistry to facilitate the convenient encapsulation of hypoxia‐induced Exo. The hydrogel swiftly transitioned into a gel state upon mixing and facilitated the controlled release of Exo at various loading dosages. Through systematic screening of Exo‐hydrogel formulations, it is demonstrated that the encapsulated Exo retained their bioactivity, exhibits therapeutic efficacy in vitro via scratch and tube formation assays. Further, the optimal Exo‐hydrogel promotes accelerated wound healing while preventing scar formation in a diabetic rat wound model. The Exo‐loaded hydrogel represents a promising approach for efficient Exo delivery in wound healing applications and holds potential for broader applications in diverse medical fields.
The Effect of Gender on the Intestinal Flora of Colorectal Cancer Under Different Stages
Authors: He Fuhai , Huang Xiaoliang , Wang Zhen , Qin Mingjian , Chen Chuanbin , Huang Zigui , Wu Yongzhi , Huang Yongqi , Tang Binzhe , Long Chenyan , Mo Xianwei , Tang Weizhong , Liu Jungang 
Published: December 2024

ABSTRACTThis study aims to determine whether gender is a factor in the interplay between the human intestinal flora and colorectal cancer (CRC), ultimately providing new evidence for the clinical prediction and management of CRC in different genders. In this study, we included 186 untreated CRC patients, and classified them into two groups based on pathological staging: Groups Ⅰ–Ⅱ and Groups Ⅲ–Ⅳ, with male and female groups within each group. We collected preoperative fecal samples from these patients and performed 16S rRNA gene sequencing to analyze their intestinal flora. In the CRC Stages I–II cohort, the gut microbiota of the female group exhibited greater diversity and abundance compared to the male group, with a total of 13 gut microbiota demonstrating significant disparities. Notably, s__Parabacteroides gordonii, s__Bacteroides faecis, and s__Bacteroides nordii were found to be more prevalent in the female group relative to the male group. Within the CRC Stages III–IV cohort, 51 gut microbiota exhibited significant differences between the genders. In the immunocyte composition of fecal samples from patients with CRC, a higher proportion of naive B cells is observed in the male group as compared to the female group. In female CRC patients within the CRC Stages III–IV cohort, Actinomyces exhibited a significant negative correlation with activated dendritic cells, CD4+ memory T cells, and eosinophils. In male CRC patients within the CRC Stages III–IV cohort, Actinomyces demonstrated a significant positive correlation with naive B cells and a significant positive correlation with immune activation genes TNFRSF25 and TMIGD2. In female CRC patients within the CRC Stages III–IV cohort, Actinomyces showed a significant negative correlation with activated dendritic cells, CD4+ memory T cells, and eosinophils, and a significant positive correlation with immune activation genes TNFSF13B, LTA, KLRK1, and CXCL12. In the CRC Stages I–II group, the female group's intestinal flora is more diverse and richer than the male group. In the CRC Stages III–IV group, there are a total of 51 different intestinal flora in both the male and female groups. We also found that Actinomyces affects the occurrence and development of CRC in the male and female groups through different pathways. The results show that the intestinal flora differs between male and female CRC patients and is closely associated with cancer development.
Tracheoesophageal Puncture Outcomes at a Safety Net Hospital
Authors: Palmer Trace T. , Hopper Samuel J. , Murray M. Caroline , Ho John , Oglesby Kacie R. , Sanford Paige , Paul Oishika , Alston Josephine S. , Jefferson Gina D. , Jackson Lana L. , Kane Anne C. 
Published: December 2024

AbstractTracheoesophageal puncture (TEP) is the gold standard for voice rehabilitation after total laryngectomy (TL). Retrospective analysis was performed of TEP outcomes in patients between 2013 and 2020 at a single tertiary hospital. TEP was performed primarily in 79%, secondarily in 6%, and not placed in 15% of 226 patients. Within the study population, 53.4% utilized their TEP, including 52% of primary and 71.4% of secondary TEPs. TEP‐related complication occurred in 50.8%, including 50.8% of primary and 50% of secondary TEPs. Secondary TEP was less likely in Black versus White patients, and more likely in patients undergoing pharyngectomy. Older patients and those with TEP complications were less likely to utilize TEP. Our study, performed in a TL population of predominantly lower socioeconomic status, showed high complication rates and low rates of utilization overall. Our findings suggest secondary TEP may be favorable to allow increased pre‐operatively counseling and patient healing prior to procedure.
Multi‐Party Semi‐Quantum Private Comparison Protocol of Size Relation with d‐Level GHZ States
Authors: Zhou Nan‐Run , Chen Zhen‐Yong , Liu Yan‐Yan , Gong Li‐Hua 
Published: December 2024

AbstractA new multi‐party semi‐quantum private comparison protocol of size relation is designed based on d‐level GHZ states. Multiple classical participants could compare their privacies while keeping them secure under an ideal environment. Compared with some similar protocols, the classical participants in the designed protocol do not need to prepare and measure quantum states. Besides, the qubit efficiency of the protocol reaches 33.33%. It is demonstrated that the output result of the proposed protocol is correct. Finally, security analysis manifests that the proposed protocol behaves well in withstanding intercept‐resend attack, measure‐resend attack, entanglement attack, Trojan horse attack, and so on.
Scientific, bibliometric and biographical analysis of 71 Jewish and dissident pharmacologists persecuted in Germany between 1933 and 1945
Authors: Mispagel Mirja , Seifert Roland 
Published: December 2024

AbstractNaunyn–Schmiedeberg’s Archives of Pharmacology, founded in 1873, is the oldest pharmacological journal. This study sheds light on the influence of persecution and expulsion of Jewish and dissident German pharmacologists during the Nazi era (1933–1945) on their scientific work and publication behaviour. The analysis is based on the German-language book ‘Verfolgte deutschsprachige Pharmakologen (persecuted German-speaking pharmacologists) 1933–1945’ by Trendelenburg and Löffelholz (2008), which contains short biographies of 71 persecuted pharmacologists. We analysed their publication activity from 1900 to 1980, the topics of the publications and the emigration data. Most persecuted pharmacologists emigrated, with two peaks of emigration around 1933 and 1938. Most pharmacologists emigrated to the USA, followed by Great Britain. Five of the scientists who emigrated to Great Britain were elected to the British Pharmacological Society’s Pharmacology Hall of Fame, and one of them was a Nobel Laureate. Very few of the emigrated pharmacologists returned to Germany. After the Nazis came to power in 1933, the share of papers by persecuted pharmacologists in Naunyn–Schmiedeberg’s Archives of Pharmacology dropped sharply. At around 1936, several of the persecuted pharmacologists began to publish increasingly in the American competitor journal, the Journal of Pharmacology and Experimental Therapeutics. The persecuted pharmacologists who emigrated to Great Britain had a major influence on the British Journal of Pharmacology, founded in 1946, as initially, they accounted for a high proportion of publications. We further analysed the papers published in Naunyn–Schmiedeberg’s Archives of Pharmacology by persecuted pharmacologists between 1933 and 1945. About half of these papers were submitted from abroad, indicating that despite the persecution and repression, papers from persecuted pharmacologists previously working at German institutes were still published during this period. Most of the papers by persecuted pharmacologists published from German institutes during this period were published under regime-critical or politically persecuted institute directors. Persecuted pharmacologists covered a huge spectrum of scientific topics, highlighting their immense scientific impact. After World War II, Naunyn–Schmiedeberg’s Archives of Pharmacology lost much of its previous thematic diversity for decades. Overall, our analyses highlight the enormous loss to German pharmacology due to the persecution, exclusion and expulsion of ‘non-Aryan’ pharmacologists. Conversely, pharmacology of the USA and Great Britain benefited greatly from the emigration of distinguished scientists from Germany.
Adverse events associated with the use of cannabis-based products in people living with cancer: a systematic scoping review
Authors: Cheah Irene , Hunter Jennifer , Gelissen Ingrid , Chan Wai-Jo Jocelin , Harnett Joanna E. 
Published: December 2024

Abstract

Purpose
To summarise the extent and type of evidence in relation to adverse events (AEs) associated with the use of cannabis-based products (CBP) in people living with cancer.

Methods
The Joanna Briggs Institute (JBI) methodology for scoping reviews was applied. A search was performed in MEDLINE (Ovid), Embase (Ovid), CINAHL (EBSCOhost), Scopus, Web of Science Core Collections and AMED (Ovid) from their inception to 7 May 2023. Primary studies reporting AEs associated with any form of natural or synthetic CBP use in any cancer care setting and location were included.

Results
One hundred fifty-two studies were included, with the most prevalent being randomised controlled trials (RCTs) (n = 61), followed by non-randomised controlled trials (n = 26) and case reports (n = 23). CBP was mainly used in gastrointestinal, liver, or peritoneal cancer (n = 98) and haematological or lymphoid cancer (n = 92), primarily to manage nausea and vomiting (n = 78) and cancer pain (n = 37). The most common CBP ingredients were combinations of THC and CBD (n = 69), synthetic THC (n = 47), single compounds of THC (n = 42) and CBD (n = 16) with diverse forms, administration routes and doses. The primary methods of administration were oral (n = 94) and inhalation (n = 54). A broad range of AEs were reported; the most common were related to the nervous system (n = 118), psychiatric (n = 101) and gastrointestinal system (n = 81). Diverse patient characteristics, significant under-reporting and low-quality reporting were observed in many studies.

Conclusions
More rigorous research designs that prioritise comprehensive, standardised reporting of AEs and CBP use are required to fully elucidate the safety profile of CBP use in cancer care.
“Hope and Hurdles” in Liver Machine Perfusion: A Review and Future Directions of Machine Perfusion in Liver Transplantation
Authors: O’Kane Lisa , Lee-Riddle Grace S. , Guarrera James V. 
Published: December 2024

Abstract
Purpose of Review
A shortage of donor organs for liver transplant has led to innovations to improve organ preservation via machine perfusion. This review evaluates the latest literature on hypothermic and normothermic machine perfusion, as well as emerging efforts to combine perfusion modalities and logistical considerations.

Recent Findings
Randomized controlled trials utilizing both hypothermic and normothermic machine perfusion establish safety and benefit for organ utilization and outcomes for liver transplant. Data regarding combined perfusion strategies are emerging, with an emphasis on expanding the donor organ pool with extended criteria donors. Logistical considerations such as cost, allocation, policy development, and education will need to be considered to facilitate more widespread adoption.

Summary
Machine perfusion is an important innovation in liver transplant that improves outcomes. Future studies are needed for expanded applications and policy development is necessary for its implementation.
Nested compressive sensing for ECG signals using novel hybrid two-level approach of DWT and DCT sensing and sparsification
Authors: Kumar Subramanyam Shashi , Ramachandran Prakash 
Published: December 2024

AbstractThis paper demonstrates the merits of nested Compressive Sensing (CS) approach for Electrocardiogram (ECG) signals using discrete wavelet transform (DWT) and discrete cosine transform (DCT) as sensing matrix and sparsifying matrix. The implementation of CS framework is done using Gradient Projection for Sparse Reconstruction (GPSR). It is tested on 9 ECG signals of different arrhythmia categories obtained from MITBIH and BIDMC dataset. It is analysed for 3 different combinations, case (1) DCT sensing and DWT sparsification, case (2) DWT sensing and DCT sparsification and case (3) DWT sensing and DWT sparsification. A novel hybrid nested CS approach is proposed as case (4) which is a combination of case (2) in higher level and case (1) in lower level. This nested method yields the best PRD of 1.39 for CR = 0.2 and performs better than all proposed cases. This proposed approach involves a fair method of discarding the measurements in all frequency band and performs better than the state of the art work when the sampling rate is reduced by 4 times for ECG signal 100.dat from MIT-BIH (Massachusetts Institute of Technology-Beth Israel Hospital) database for CR = 0.2. It is shown that the reconstruction time of the proposed nested CS approach is lesser than non-nested CS approach.
Challenges and advances in nanocellulose-based adsorbents for dye removal: mechanisms and future directions
Authors: Nagendran Vasundra , Goveas Louella Concepta , Vinayagam Ramesh , Varadavenkatesan Thivaharan , Selvaraj Raja 
Published: December 2024

AbstractThe rapid growth of the textile industry has led to a sharp increase in dye-filled wastewater, posing a significant environmental concern. Adsorption is a promising method for dye removal, but traditional adsorbents often fall short due to limited capacity, lack of sustainability, and low selectivity. Nanocellulose-based materials have shown great potential, with some achieving high adsorption capacities, such as 3429.23 mg/g for Congo Red on cellulose-based aerogel and 2282.3 mg/g for malachite green on magnetic nanocellulose-based adsorbents. These adsorbents follow various adsorption models, including Langmuir and Freundlich isotherms, and kinetic models such as the pseudo-second-order model indicating strong interactions with target dyes. This review thoroughly examines nanocellulose-based adsorbents, exploring their types, properties, and preparation methods. This review analyses dye interactions, including factors influencing adsorption, and provides an in-depth look at adsorption kinetics, isotherms, and thermodynamics. Also, this review aims to clarify the true potential of nanocellulose-based adsorbents for dye removal, summarizing recent advancements while identifying research gaps and future directions to support further development in this field.
Legendre wavelet based numerical method for the solution of marangoni convective flow of dusty ree-erying fluid over a riga plate with activation energy
Authors: Shiralashetti S. C. , Kulkarni Priyanka I. , Hanaji Savita I. 
Published: December 2024

AbstractLegendre wavelet based numerical method has been developed for the solution of the system of non-linear differential equations arising in the study of a Marangoni convective flow of dusty Ree-Erying fluid over a Riga plate in Darcy-Forchheimer medium with Soret, Dufour, non-linear radiation, activation energy effects and entropy generation analysis. The proposed method is validated by comparing the solutions of the test problem with the Bernoulli wavelet based numerical method and the exact solution and by comparing the results of the considered dusty fluid problem for some fixed parameters with the previously published results. The effects of various factors on the velocity, thermal, concentration attributes are studied by using the proposed method. It is observed that the Ree-Erying fluid parameter and Marangoni ratio parameter escalates the velocity and declines the temperature and concentration. The opposite behaviour is observed for Deborah number. The concentration declines for higher chemical reaction parameter and improves for activation energy. Both entropy generation and Bejan number escalates for radiation parameter and diffusion parameter. The proposed method is reliable, fast computable and powerful tool to solve the differential equations.
Minds and machines: evaluating the feasibility of constructing an advanced artificial intelligence
Authors: Sgantzos Konstantinos , Stelios Spyridon , Tzavaras Panagiotis , Theologou Kostas 
Published: December 2024

AbstractIt is a popular hypothesis for researchers worldwide that if we manage to construct a lifelike intelligence that depicts most aspects of the human brain, it will be easier for us to understand our own existence. This discussion often ends up in polemic altercations between philosophers, neuroscientists, and technologists on the definition of intelligence. It has also been a subject of interest in both academic and industrial societies, with two prominent concepts emanating at the peak of it, often as one and the same: Artificial Intelligence and Natural Intelligence. While these terms are often used interchangeably, we theorize that they represent two totally distinct and often contradictory constructs. This work aims to portray the most significant divergences between Artificial Intelligence and Natural Intelligence and find out if those can converge under the current technological advancements. We focus primarily on their accurate definitions, then their inner workings, and their potentials and limitations enumerating in the process relative sociological and ethical consequences. Finally, we show why under the current methods the probability of creating an advanced form of Artificial Intelligence is minimal.
Increased IDO expression and regulatory T cells in acute myeloid leukemia: implications for immune escape and therapeutic targeting
Authors: Hakak Raziyeh , Poopak Behzad , Majd Ahmad 
Published: December 2024

Abstract
Purpose
This study aimed to determine the frequency of regulatory T cells (Tregs) (CD4+/FOXP3+) and indoleamine 2,3-dioxygenase (IDO) expression in patients with acute myeloid leukemia (AML).

Methods
This cross-sectional case–control study was conducted between Jan 2022 and Dec 2023. Bone marrow samples were collected from 20 healthy individuals and 15 patients with AML. Flow cytometry, real-time polymerase chain reaction (PCR), and western blotting were used to evaluate the frequency of Treg and IDO expression levels.

Results
The Treg percentage among total lymphocytes was lower in the AML group than that in the normal group. However, Treg percentage among T-helper (Th) lymphocytes was significantly higher in the AML group than that in the normal group (p < 0.05). The mean IDO expression in the AML group was significantly higher than that in the normal group (p = 0.004). A significant relationship was observed between IDO expression and Treg percentage among Th lymphocytes in the AML group (correlation = 0.637; p = 0.003). Moreover, western blot analysis showed a significant increase in IDO protein intensity in the AML group compared with that in the control group (p < 0.001). A significant difference was observed between the IDO concentrations in the AML group and that in the control group (p < 0.001). In addition, a significant difference between TGF-β levels in the AML group and those in the control group (p < 0.01) was observed.

Conclusion
IDO inhibition using novel IDO inhibitors along with chemotherapy is a promising approach to overcome the immune escape mechanisms in patients with AML, who exhibit increased levels of IDO expression and Tregs.
Religious involvement and subjective wellbeing among older adults in Taiwan: exploring gender and age differences
Authors: Zhang Keqing , Zhang Wei , Ellison Christopher G. , Wang Wei-Pang 
Published: December 2024

Abstract
This study addresses a significant knowledge gap in the literature by examining the relationship between religious involvement and subjective wellbeing (SWB) among older adults in Taiwan, a cultural context that has been underrepresented in existing research, with a focus on gender and age differences. Using data collected in Taichung City in 2017 (N = 645), this study measured religious involvement through religious affiliation, religiosity and frequency of religious participation, and assessed SWB via life satisfaction and happiness. Findings revealed no significant association between religious involvement and life satisfaction. However, religious participation was positively correlated with happiness. Gender differences were observed: Buddhism and Taoism were positively associated with life satisfaction among males, whereas religiosity and religious participation were significantly related to life satisfaction and happiness among females. Age disparities were also found, with religiosity significantly relating to both life satisfaction and happiness in the old-old group (70–89 years) but not in the young-old group (60–69 years). These findings highlight the nuanced associations between religious involvement and SWB, emphasising the importance of considering gender and age variations in future research. Future studies should further explore the cultural contexts that shape these relationships and examine other potential mediating factors to provide a more comprehensive understanding of how religious involvement influences wellbeing across different demographic groups.