bluuebunny/crossref_metadata_2025_split huggingface dataset:
A drug repurposing screen identifies hepatitis C antivirals as inhibitors of the SARS-CoV-2 main protease
Authors: Baker Jeremy D. , Uhrich Rikki L. , Kraemer Gerald C. , Love Jason E. , Kraemer Brian C. 
Published: July 2020

AbstractThe SARS coronavirus type 2 (SARS-CoV-2) emerged in late 2019 as a zoonotic virus highly transmissible between humans that has caused the COVID-19 pandemic1,2. This pandemic has the potential to disrupt healthcare globally and has already caused high levels of mortality, especially amongst the elderly. The overall case fatality rate for COVID-19 is estimated to be ∼2.3% overall3and 32.3% in hospitalized patients age 70-79 years4. Therapeutic options for treating the underlying viremia in COVID-19 are presently limited by a lack of effective SARS-CoV-2 antiviral drugs, although steroidal anti-inflammatory treatment can be helpful. A variety of potential antiviral targets for SARS-CoV-2 have been considered including the spike protein and replicase. Based upon previous successful antiviral drug development for HIV-1 and hepatitis C, the SARS-CoV-2 main protease (Mpro) appears an attractive target for drug development. Here we show the existing pharmacopeia contains many drugs with potential for therapeutic repurposing as selective and potent inhibitors of SARS-CoV-2 Mpro. We screened a collection of ∼6,070 drugs with a previous history of use in humans for compounds that inhibit the activity of Mproin vitro. In our primary screen we found ∼50 compounds with activity against Mpro (overall hit rate <0.75%). Subsequent dose validation studies demonstrated 8 dose responsive hits with an IC50 ≤ 50 μM. Hits from our screen are enriched with hepatitis C NS3/4A protease targeting drugs including Boceprevir (IC50=0.95 μM), Ciluprevir (20.77μM). Narlaprevir (IC50=1.10μM), and Telaprevir (15.25μM). These results demonstrate that some existing approved drugs can inhibit SARS-CoV-2 Mpro and that screen saturation of all approved drugs is both feasible and warranted. Taken together this work suggests previous large-scale commercial drug development initiatives targeting hepatitis C NS3/4A viral protease should be revisited because some previous lead compounds may be more potent against SARS-CoV-2 Mpro than Boceprevir and suitable for rapid repurposing.
Obesity, walking pace and risk of severe COVID-19: Analysis of UK Biobank
Authors: Yates Thomas , Razieh Cameron , Zaccardi Francesco , Seidu Samuel , Davies Melanie J , Khunti Kamlesh 
Published: July 2020

Unstructured abstractObesity is an emerging risk factor for coronavirus disease-2019 (COVID-19). Simple measures of physical fitness, such as self-reported walking pace, could also be important risk factors, but have not been well documented. This analysis includes 414,201 UK Biobank participants with complete covariate and linked COVID-19 data. We analysed the risk of severe (in-hospital) COVID-19 across categories of obesity status and walking pace. As of June 20th 2020 there were 972 cases of severe COVID-19 that had occurred within the cohort. Compared to normal weight individuals, the adjusted odds ratio (OR) for severe COVID-9 in those with obesity was 1.49 (1.24, 1.78). Compared to those with a brisk walking pace, the OR in slow walkers was 1.84 (1.49, 2.27). Slow walkers had the highest risk of severe COVID-19 regardless of obesity status. For example, compared to normal weight brisk walkers, the odds of severe COVID-19 in obese brisk walkers was 1.39 (0.99, 1.98), whereas the odds in normal weight slow walkers was 2.48 (1.56, 3.93). Self-reported walking pace, a simple measure of functional fitness, appears to be a risk factor for severe COVID-19 that is independent of obesity. This may help inform simple pragmatic public health risk stratification and preventative strategies.
Estimating the distribution of time to extinction of infectious diseases in mean-field approaches
Authors: Aliee Maryam , Rock Kat S. , Keeling Matt J. 
Published: July 2020

AbstractA key challenge for many infectious diseases is to predict the time to extinction under specific interventions. In general this question requires the use of stochastic models which recognise the inherent individual-based, chance-driven nature of the dynamics; yet stochastic models are inherently computationally expensive, especially when parameter uncertainty also needs to be incorporated. Deterministic models are often used for prediction as they are more tractable, however their inability to precisely reach zero infections makes forecasting extinction times problematic. Here, we study the extinction problem in deterministic models with the help of an effective “birth-death” description of infection and recovery processes. We present a practical method to estimate the distribution, and therefore robust means and prediction intervals, of extinction times by calculating their different moments within the birth-death framework. We show these predictions agree very well with the results of stochastic models by analysing the simplified SIS dynamics as well as studying an example of more complex and realistic dynamics accounting for the infection and control of African sleeping sickness (Trypanosoma brucei gambiense).
Neutralizing Antibody Responses in COVID-19 Convalescent Sera
Authors: Lee William T. , Girardin Roxanne C. , Dupuis Alan P. , Kulas Karen E. , Payne Anne F. , Wong Susan J. , Arinsburg Suzanne , Nguyen Freddy T. , Mendu Damodara Rao , Firpo-Betancourt Adolfo , Jhang Jeffrey , Wajnberg Ania , Krammer Florian , Cordon-Cardo Carlos , Amler Sherlita , Montecalvo Marisa , Hutton Brad , Taylor Jill , McDonough Kathleen A. 
Published: July 2020

AbstractPassive transfer of antibodies from COVID-19 convalescent patients is being used as an experimental treatment for eligible patients with SARS-CoV-2 infections. The United States Food and Drug Administration’s (FDA) guidelines for convalescent plasma recommends target antibody titers of 160. We evaluated SARS-CoV-2 neutralizing antibodies in sera from recovered COVID-19 patients using plaque reduction neutralization tests (PRNT) at low (PRNT50) and high (PRNT90) stringency thresholds. We found that neutralizing activity increased with time post symptom onset (PSO), reaching a peak at 31-35 days PSO. At this point, the number of sera having neutralizing titers of at least 160 was ∼93% (PRNT50) and ∼54% (PRNT90). Sera with high SARS-CoV-2 antibody levels (>960 ELISA titers) showed maximal activity, but not all high titer sera contained neutralizing antibody at FDA recommended levels, particularly at high stringency. These results underscore the value of serum characterization for neutralization activity.
Magnitude and time-course of excess mortality during COVID-19 outbreak: population-based empirical evidence from highly impacted provinces in northern Italy
Authors: Conti Sara , Ferrara Pietro , Mazzaglia Giampiero , D’Orso Marco I. , Ciampichini Roberta , Fornari Carla , Madotto Fabiana , Magoni Michele , Sampietro Giuseppe , Silenzi Andrea , Sileo Claudio V. , Zucchi Alberto , Cesana Giancarlo , Manzoli Lamberto , Mantovani Lorenzo G. 
Published: July 2020

AbstractBackgroundThe real impact of SARS-CoV-2 on overall mortality remains uncertain and surveillance reports attributed to COVID-19 a limited amount of deaths during the outbreak. Aim of this study is to assess the excess mortality (EM) during COVID-19 outbreak in highly impacted areas of northern Italy.MethodsWe analyzed data on deaths occurred in the first four months of 2020 in health protection agencies (HPA) of Bergamo and Brescia (Lombardy), building a time-series of daily number of deaths and predicting the daily standardized mortality ratio (SMR) and cumulative number of excess deaths (ED) through a Poisson generalized additive model of the observed counts in 2020, using 2019 data as a reference.ResultsWe estimated 5740 (95% Credible Set (CS): 5552–5936) ED in the HPA of Bergamo and 3703 (95% CS: 3535 – 3877) in Brescia, corresponding to 2.55 (95% CS: 2.50–2.61) and 1.93 (95% CS: 1.89–1.98) folds increase in the number of deaths. The ED wave started a few days later in Brescia, but the daily estimated SMR peaked at the end of March in both HPAs, roughly two weeks after the introduction of lock-down measures, with significantly higher estimates in Bergamo (9.4, 95% CI: 9.1–9.7).ConclusionEM was significantly larger than that officially attributed to COVID-19, disclosing its hidden burden likely due to indirect effects on health system. Time-series analyses highlighted the impact of lockdown restrictions, with a lower EM in the HPA where there was a smaller delay between the epidemic outbreak and their enforcement.
Drivers of soccer fan loyalty: Australian evidence on the influence of team brand image, fan engagement, satisfaction and enduring involvement
Authors: Yun Jin Ho , Rosenberger Philip J. , Sweeney Kristi 
Published: July 2020

PurposeThe purpose of the paper is to contribute to the extant sport marketing literature by positing fan engagement, team brand image and cumulative fan satisfaction with the team as factors influencing attitudinal and behavioural soccer (football) fan loyalty, with enduring involvement with the team as a moderator.Design/methodology/approachA convenience sample of Australian A-League soccer fans completed a paper-and-pencil, self-administered survey to evaluate their team on the focal constructs. A total of 207 participants were recruited from a major Australian east-coast university.FindingsUsing partial least squares-structural equation modelling (PLS-SEM), the study found that fan engagement influences both team brand image and cumulative fan satisfaction, while team brand image also influences cumulative fan satisfaction, and both of these constructs influence attitudinal loyalty and behavioural loyalty. The moderating role of enduring involvement was also found for two relationships: team brand image → attitudinal loyalty and team brand image → behavioural loyalty, along with a mediating role of attitudinal loyalty.Originality/valueThis study increases our understanding of the reasons why soccer fans are committed to and exhibit fan-related behaviours for a team, thus contributing to the sports-marketing literature on the relationships amongst fan engagement, team brand image, cumulative fan satisfaction, attitudinal loyalty and behavioural loyalty, along with the moderating role of enduring involvement. The findings also assist sports-marketing practitioners to formulate more effective, fan-centric marketing-communication strategies leading to a larger loyal fan base.
Systematic literature review of project manager's leadership competencies
Authors: Ahmed Riaz , Philbin Simon P. , Cheema Farooq-e-Azam 
Published: July 2020

PurposeOver the last few decades, a large number of research studies have been carried out on project manager's leadership competencies. However, systematic literature reviews are still scarce in the project management literature. Therefore, the purpose of this article is to conduct a systematic literature review on project manager's leadership competencies based on published empirical research studies.Design/methodology/approachThe authors employed a systematic literature review (SLR) methodology to synthesize research in a rigorous manner and a total of 1,780 articles were identified in the first step and a final sample of 60 research studies were synthesized.FindingsSynthesis of the findings in this SLR on project manager's leadership competencies revealed: (a) there is a lack of categorization or ranking of leadership competencies; (b) 20 research studies (46%) were conducted with sample sizes of less than 100; (c) only a few research studies (<10%) used interview data for analysis; and (d) none of the research studies reported adoption of a triangulation method.Research limitations/implicationsThis study synthesized clusters of leadership competencies and prioritized project manager's leadership competencies as “high priority”, “moderate priority” and “low priority”. We recommend a sample size between 200 and 300 to produce sophisticated results and enhance the credibility, generalizability and validity of clusters and priorities of project manager's leadership competencies through future research.Originality/valueFuture research studies are suggested to consider systematic literature review combined with face-to-face and group interview in addition to employing triangulation methods. Besides highlighting implications for practitioners, this SLR has advanced the understanding of how to conduct systematic literature reviews in a robust manner.
Development and validation of the Expanded Mindful Eating Scale
Authors: Kawasaki Yui , Akamatsu Rie , Omori Mika , Sugawara Masumi , Yamazaki Yoko , Matsumoto Satoko , Fujiwara Yoko , Iwakabe Shigeru , Kobayashi Tetsuyuki 
Published: July 2020

PurposeTo develop and validate the Expanded Mindful Eating Scale (EMES), an expanded mindful eating model created for the promotion of health and sustainability.Design/methodology/approachA cross-sectional study using self-administered questionnaire surveys on Ochanomizu Health Study (OHS) was conducted. The survey was provided to 1,388 female university students in Tokyo, Japan. Exploratory factor analysis (EFA), confirmatory factor analysis (CFA) and a partial correlation analysis were used to confirm construct and criterion validity. Internal consistency of the EMES was confirmed to calculate Cronbach's alpha.FindingsThe response rate was 38.7 % (n = 537). Mean BMI was 20.21 ± 2.12, and 18.8% of them were classified as “lean” (BMI < 18.5). The authors listed 25 items and obtained a final factor structure of five factors and 20 items, as a result of EFA. Through CFA, the authors obtained the following fit indices for a final model: GFI = 0.914, AGFI = 0.890, CFI = 0.870 and RMSEA = 0.061. The total EMES score was significantly correlated with BMI, mindfulness, body dissatisfaction, drive for thinness and life satisfaction (r = −0.138, −0.315, −0.339, −0.281 and 0.149, p < 0.01, respectively). Cronbach's alpha for all items in this scale was 0.687.Practical implicationsThe authors suggest the possibility that practitioners and researchers of mindful eating that includes this new concept can use authors’ novel scale as an effective measurement tool.Originality/valueThe EMES, which can multidimensionally measure the concept of the expanded model of mindful eating was first developed in this study.
Identification and prioritization of stage-level KPIs for BOT projects – evidence from Turkey
Authors: Budayan Cenk , Okudan Ozan , Dikmen Irem 
Published: July 2020

PurposeThe purpose of this paper is to identify and prioritize key performance indicators (KPIs) that can be used for stage-based performance assessment of build-operate-transfer (BOT) projects.Design/methodology/approachThis research was conducted through focus group discussions and face-to-face questionnaires. Firstly, stage-level KPIs for BOT projects were identified by conducting a literature survey. The list of KPIs that can be used for measuring performance at different stages of a BOT project was finalized by conducting focus group discussions with 12 participants. The data related to the importance of identified KPIs were collected via a face-to-face questionnaire in which 30 high-level managers participated. Based on these data, KPIs were prioritized considering eight different stages of a BOT project by using Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS).FindingsThe research findings reveal that 63 stage-level KPIs can be used for measuring the performance of BOT projects at eight different stages, which are “feasibility study and preliminary plan,” “announcement and submission of application,” “evaluation and selection,” “negotiation and signing of concession agreement,” “design,” “construction,” “operation” and “transfer.” The most important KPIs were determined as “comprehensiveness of project technical feasibility,” “detailed tendering procedure,” “effectiveness of concessionaires' technical knowledge/capability evaluation,” “good relationships between government and concessionaire,” “technology transfer,” “effectiveness of quality control,” “effectiveness of facility management” and “effectiveness of hand-back management” for each stage. The findings can be used by companies to evaluate performance at each stage of a BOT project and, if necessary, take the necessary actions for performance improvement at the stage level.Research limitations/implicationsThe main limitation is the size of the sample, which represents the perspectives of 30 Turkish high-level managers on KPIs in BOT projects. Besides, the selected method, namely, TOPSIS, does not provide quality measures related to the outputs; therefore, it is difficult to see the inconsistencies among the experts.Practical implicationsThe study findings will help in devising appropriate performance evaluation practices for BOT projects to overcome the shortfalls of the existing practices and systems proposed in the literature and help in achieving the superior performance while developing infrastructure through the BOT route.Originality/valueThis paper proposes a process-based approach for measuring the performance of a BOT project considering eight different stages. It fills a research gap in the public–private partnership literature by focusing on stages rather than phases. The results can be used by practitioners to establish stage-level performance management systems for BOT projects.
Consumers' perceptions and responses towards online retailers' CSR
Authors: Dang Van Thac , Nguyen Ninh , Wang Jianming 
Published: July 2020

PurposeAnchored on social trust theory, social identity theory and signalling theory, this study investigates the process of how consumers respond to online retailers' corporate social responsibility (CSR).Design/methodology/approachFollowing the hypo-deductive research design, a unique model was developed to link online retailers' CSR with consumer purchase intention through brand identification and word of mouth (WOM). This model was subsequently tested and validated by conducting an online survey to 239 customers of a major online retailer in China, that is, JD.com.FindingsAnalysis using structural equation modelling demonstrates that online retailers' CSR is positively associated with consumer purchase intention, and brand identification positively mediates such an association. In addition, WOM exhibits a mediating effect on the relationship between perceived online retailers' CSR and consumer purchase intention and between brand identification and consumer purchase intention.Practical implicationsOnline retailers must endeavour to employ CSR as a strategy to enhance consumer purchase intention and behaviour. Moreover, they should develop communication programmes that highlight their engagement in CSR activities to improve their brand image and facilitate consumers' positive WOM.Originality/valueTo the best of the researchers' knowledge, this study is the first to examine the mediating roles of brand identification and WOM in the relationship between online retailers' CSR and customer purchase intention. Furthermore, this study extends current knowledge about online retailers' CSR and its potential impact in emerging economies by focussing on the context of China.
Firms enabling responsible consumption: a netnographic approach
Authors: Kumar Bipul , Dholakia Nikhilesh 
Published: July 2020

PurposeThis study explores enablers that firms could use to motivate consumers toward responsible consumption behavior. Completing the loop of responsible consumption – linking firms and consumers –helps firms to attain responsible consumption targets as part of the sustainable development goals (SDGs).Design/methodology/approachThe study uses netnography as the qualitative research methodology.FindingsThe important enablers of responsible consumption behavior are choice editing, design intervention, addressing consumers' environmental identity, brand assurance, promoting innovation mindset and consumer empowerment – at the level of consumers and at the crosslevel of interaction between firms and consumers. Such enablers can help the firms in nudging their consumers toward responsible consumption.Research limitations/implicationsUsing the lens of the expectancy–value theory of achievement motivation, this study extends the theoretical domain of responsible consumption.Practical implicationsThe enablers of responsible consumption behaviors found here serve as a useful guide for the strategies to attain the SDGs.Social implicationsThe SDG goal 12 of responsible consumption is the focus of this study. The entire fabric of responsible consumption is woven around anthropocentric views, and hence the findings of this study have clear social implications.Originality/valueThis is a first study to explore how firms can facilitate consumers to consume responsibly, to attain the SDGs. This is also one of the first studies on responsible consumption, using netnography as the research methodology. Additionally, it also extends the applicability of the expectancy–value theory of achievement motivation to the context of responsible consumption behavior.
Sustainability, responsibility and ethics: different concepts for a single path
Authors: Torelli Riccardo 
Published: July 2020

Purpose
The purpose of this paper is to analyse the concepts of sustainability, responsibility and ethics focussing on their links and differences, also to understand how companies move respectively in these field; to understand how companies sometimes move away from the basic and deep meaning of these concepts, landing in a merely utilitarian sphere of personal advantage where ethics, instead of being an irreplaceable and essential stronghold, is found to be a fiction or just an instrument.

Design/methodology/approach
The methodology used assumes a theoretical critical approach and, based on the vast literature on the items, is based on a conceptual analysis of the themes of sustainability, corporate social responsibility (CSR) and ethics and of the behaviour that companies can adopt in the three contexts. A critical approach to these issues and concepts can effectively help us to understand how companies are responding to external demands and to the challenges of responsibility and sustainability, which are becoming increasingly pressing.

Findings
Ethics, sustainability, CSR and social and environmental reporting are distinct constructs with different meanings but linked by important conceptual and operational relationships.

Research limitations/implications
The results of the research are the consequence of the application of a critical approach based on a theoretical analysis of the concepts under study. It would be interesting to support the results achieved with empirical research studies.

Practical implications
This conceptual path helps scholars and companies themselves to understand the difference between the three key concepts analysed. Only by understanding the basic meaning will it be possible to really make one’s own and pursue it in the correct way.

Social implications
Nowadays, the authors are overwhelmed by these three concepts which are used as synonyms and incorrectly. This leads to confusion and misunderstandings. Knowledge of the characteristics and differences between these concepts and their concrete applications is of great importance.

Originality/value
This study tries to provide a critical discussion of how the three concepts intersect and differentiate, leading to concrete results or results that have nothing to do with their meaning. There are no conceptual papers in the literature that deal with the three concepts and also analyse the implications on the real world.