bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of a Field Hamstring Eccentric Training on Muscle Strength
and Flexibility
Authors: Delvaux François , Schwartz Cedric , Decréquy Thibault , Devalckeneer Thibault , Paulus Julien , Bornheim Stephen , Kaux Jean-François , Croisier Jean-Louis 
Published: January 2020

AbstractMuscle strength imbalances and poor flexibility are frequently described as
risk factors for hamstring injury. Preventive strategies include eccentric
exercises, but the influence of field eccentric exercises on these risk
factors remains unclear. We investigated the influence of a field hamstring
eccentric program on hamstring strength and flexibility. Twenty-seven
amateur athletes were randomly assigned to an intervention (n=13) or
control group (n=14). In the intervention group, participants were
involved in 15 sessions of four eccentric exercises. Peak torque,
hamstring-to-quadriceps ratios, passive and active flexibility were
analyzed. No significant modifications of strength, passive or active
flexibility were observed in the control group (p>0.05). Hamstring
eccentric peak torque (+7.1%) and functional
hamstring-to-quadriceps ratios (9.3%) were significantly increased
(p<0.05) in the intervention group, but not concentric strength
(p<0.05). Passive straight leg raise was significantly increased by
11.4° (+12.7%, p<0.001), but not active
flexibility (+3.1%, p>0.05). In conclusion, a 6-week
eccentric program, including four field exercises for hamstring muscles, is
an effective method of improving eccentric strength, functional ratios and,
especially, passive flexibility. As this program may be easily implemented
in a real-world context, this association of multiple eccentric exercises
might be useful in an injury prevention strategy.
Total and Regional Body Composition of NCAA Division I Collegiate
Basketball Athletes
Authors: Raymond-Pope Christiana J. , Solfest Anna L. , Carbuhn Aaron , Stanforth Philip R. , Oliver Jonathan , Bach Christopher W. , Bosch Tyler , Dengel Donald R. 
Published: January 2020

AbstractThis study aimed to examine body composition using dual X-ray absorptiometry
(DXA) in male and female NCAA Division I collegiate basketball athletes.
Two-hundred ten (male [M]/female [F]=88/122)
basketball athletes’ total and regional fat mass, lean mass, bone
mineral density, and visceral adipose tissue were measured. Athletes were
classified as: point guards (M/F=27/34), shooting
guards (M/F=18/27), small forwards
(M/F=13/18), power forwards
(M/F=21/27), and centers
(M/F=9/16). ANOVA and Tukey’s HSD assessed
positional differences by sex. In males, centers and power forwards had
greater total fat mass (p<0.025), lean mass (p≤0.001), and
visceral adipose tissue (p<0.001) than other positions. Male centers
had greater arm and leg fat mass and lean mass than point guards, shooting
guards, and small forwards (p≤0.049), and greater arm bone mineral
density than point guards (p=0.015). In females, centers had greater
total fat mass (p<0.001) vs. other positions and greater total lean
mass, arm fat and lean masses, arm and leg bone mineral density, and
visceral adipose tissue vs. point guards and shooting guards
(p≤0.005). Female point guards had lower total bone mineral density
than power forwards (p=0.008). In conclusion, these sex- and
position-specific total and regional body composition measurements in
collegiate basketball players provide population-specific normative
data.
Exercise Interventions and Cardiovascular Health in Childhood Cancer:
A Meta-analysis
Authors: Morales Javier S. , Valenzuela Pedro L. , Herrera-Olivares Alba M. , Baño-Rodrigo Antonio , Castillo-García Adrián , Rincón-Castanedo Cecilia , Martín-Ruiz Asunción , San-Juan Alejandro F. , Fiuza-Luces Carmen , Lucia Alejandro 
Published: January 2020

AbstractThis study analyzed the effects of physical exercise interventions on
cardiovascular endpoints in childhood cancer survivors. Relevant articles
were systematically searched in PubMed, CINAHL, and Web of Science databases
(since inception to 11th September 2019). We performed a meta-analysis
(random effects) to determine the mean difference (expressed together with
95% confidence intervals) between pre- and post-intervention values
for those cardiovascular endpoints reported in more than three studies.
Twenty-seven studies (of which 16 were controlled studies) comprising 697
participants were included. Only three studies reported adverse events
related to exercise interventions. Exercise resulted in an increased
performance on the 6-minute walk distance test (mean
difference=111 m, 95% confidence
interval=39–183, p=0.003) and a non-significant
trend (mean
difference=1.97 ml∙kg−1∙min−1,
95% confidence interval=−0.12–4.06,
p=0.065) for improvement in peak oxygen uptake. Furthermore, left
ventricular ejection fraction was preserved after exercise interventions
(mean difference=0.29%, 95% confidence
interval=−1.41–1.99, p=0.738). In summary,
exercise interventions might exert a cardioprotective effect in childhood
cancer survivors by improving – or attenuating the decline of
– physical capacity and cardiovascular function. Further studies,
particularly randomized controlled trials, are needed to confirm these
benefits.
Early Rupture of a Giant Basilar Artery Aneurysm after LEO Stenting: Case Report and Review of the Literature
Authors: Strange Fabio , Kienzler Jenny , Muehleisen Beda , Diepers Michael , Fandino Javier , Remonda Luca , Marbacher Serge 
Published: January 2020

Background Advances in the endovascular armamentarium, such as flow diversion and stenting devices, provide treatment options for posterior circulation intracranial aneurysms (IAs) with complex angioarchitecture. Delayed IA rupture following flow diversion is a rare but often fatal complication. Giant IAs likely pose a higher risk because of the extensive clot formation and its suspected detrimental effect on the aneurysmal wall. However, mechanisms that lead to delayed rupture are poorly understood, and few cases provide thorough documentation of macroscopic and histologic findings.
Clinical Presentation After our 60-year-old patient with a giant basilar aneurysm underwent treatment with a LEO stent, the postoperative clinical course remained uneventful until day 4 when he suffered an unexpected fatal subarachnoid hemorrhage (SAH). Autopsy demonstrated extensive hemorrhage, large intraluminal thrombus, and ruptured IA wall. The aneurysm, which ruptured linearly, was completely filled with a clot that seemed to have outgrown the thin aneurysm wall. Histologic specimens revealed thinning and degenerative changes of the aneurysm's wall, and sparse neutrophilic and histiocytic inflammatory infiltrate adjacent to the rupture site, a finding consistent with recently published cases of IA rupture.
Conclusions Our case report highlighting the clinical course and autopsy findings of a fatal SAH shortly after stenting this giant basilar artery aneurysm adds to the few previously reported fatal cases of IA rupture after endovascular treatment. Our macroscopic and histologic findings suggested that multimodal changes of inflammation, wall sheer tress (mechanical), and recanalization were involved.
Continuous Dynamic Mapping to Identify the Corticospinal Tract in Motor Eloquent Brain Tumors: An Update
Authors: Seidel Kathleen , Schucht Philippe , Beck Jürgen , Raabe Andreas 
Published: January 2020

Abstract
Objective We recently developed a new subcortical mapping technique based on the concept of stimulating the tissue at the site of and synchronously with resection. Our hypothesis was that instead of performing resection and mapping sequentially, a synchronized resection and mapping could potentially improve deficit rates.
Methods We report our 5-year series of patients who prospectively underwent tumor surgery adjacent to the corticospinal tract (CST) (defined as < 1 cm using diffusion tension imaging and fiber tracking) with simultaneous subcortical short train cathodal monopolar mapping, equipped with a new acoustic motor evoked potential (MEP) alarm. Continuous (temporal coverage) and dynamic (spatial coverage) mapping was realized technically by integrating the mapping probe at the tip of a new suction device. Motor function was assessed using the Medical Research Council scale (from M1 to M5) 1 day after surgery, at discharge, and at 3 months.
Results Technically, the method was successful in all 182 cases. The lowest individual motor thresholds reached during resection were > 10 mA, n = 56; 6–10 mA, n = 31; 4–5 mA, n = 37; and 1–3 mA, n = 58. At 3 months, six patients (3%) had a persisting postoperative motor deficit that was caused by direct mechanical injury in three of these patients (1.7%).
Conclusions Continuous dynamic mapping was found to be a feasible and ergonomic technique for localizing the exact site of the CST and distance to the motor fibers. This new technique may improve the safety of motor eloquent tumor surgery.
Dual Pathologies: Pial Arteriovenous Fistula in Combination with an Arteriovenous Malformation
Authors: Jannelli Gianpaolo , Joswig Holger , Bernava Gianmarco , Meling Torstein R. , Bijlenga Philippe 
Published: January 2020

Abstract
Background A pial arteriovenous fistula (PAVF) is a rare neurovascular pathology consisting of a direct connection between one or more arterial feeders and a single venous channel. A PAVF was previously considered a subtype of an arteriovenous malformation (AVM). In the current literature these are distinguished as two independent entities with different clinical, physiopathologic, and structural characteristics. We report a case of a surgically treated 37-year-old woman with an extremely rare combination of an unruptured PAVF and AVM.
Patient The AVM was mainly supplied by feeders of the middle cerebral artery and drained into the sigmoid sinus via an abnormally dilated and tortuous vein. Following its resection, intraoperative digital subtraction angiography (DSA) in the hybrid operating room revealed the presence of a PAVF that had not been noted during the preoperative planning. Hence the PAVF was completely disconnected as confirmed by DSA again.
Conclusion This is the second reported case of an AVM-associated PAVF. Without the intraoperative DSA in the hybrid operating room, this unusual complex cerebrovascular entity would likely have been missed.
Hot Water Epilepsy
Authors: Torres Alcy R. , Aquino-Cabrera Marleny , Mohanty Mugdha 
Published: January 2020

AbstractHot water epilepsy (HWE) is a type of reflex epilepsy in which seizures are precipitated by pouring water at a higher temperature during bathing onto the head or body. The etiology is still not known and is presumably both genetic and environmental. Focal seizures with impaired awareness are the most common seizure types and generalized tonic-clonic seizures are the second common type of seizures. The diagnosis is clinical. Interictal electroencephalography and neuroimaging are usually normal. Treatment consists of avoidance of the triggering factor. However, in cases where this option is not effective, antiepileptics can be used. Clobazam appears to be the most effective therapy, particularly for pure HWE. This is an up-to-date review of the literature.
Do We Need Chemoprophylaxis to Prevent Venous Thromboembolism following Medial Open-Wedge High Tibial Osteotomy?
Authors: Kim Kang-Il , Kim Gi Beom , Lee Myeong Gu , Song Sang Jun 
Published: January 2020

AbstractThe aim of this study was to investigate the overall incidence of venous thromboembolism (VTE) and to assess the efficacy of chemoprophylaxis to prevent VTE following medial open-wedge high tibial osteotomy (MOWHTO) in Asian patients. A total of 133 patients who consecutively underwent MOWHTO for the treatment of knee osteoarthritis with varus deformity were enrolled. All patients underwent preoperative ultrasonography and computed tomography venography on postoperative day 5 to detect deep vein thrombosis (DVT). Patients were divided into two groups: chemoprophylaxis group included patients (n = 66) who received 2.5 mg fondaparinux for 5 days postoperatively, whereas control group comprised patients (n = 67) who received placebo (67 patients). We evaluated the efficacy and safety outcomes of the treatment. We also assessed the predisposing factors that may affect the occurrence of VTE. The incidence of overall DVT was 14.9% in the control group and 10.6% in the chemoprophylaxis group (p > 0.05). Proximal DVT occurred in one patient in the control group. There was no symptomatic DVT or pulmonary embolism in either group. The patients with DVT had significantly higher mean body mass index (BMI) than the patients without DVT. Multivariate logistic regression showed BMI > 30 kg/m2 that was significantly correlated with the development of DVT (odds ratio = 0.8; p = 0.017). There were no cases of major bleeding; however, minor bleeding episodes occurred in four patients in the chemoprophylaxis group. The current study showed that the overall incidence of VTE following MOWHTO was low in Asian patients even without chemoprophylaxis. Therefore, routine chemoprophylaxis following MOWHTO seems to be not necessary in a population with low-VTE incidence. However, selective chemoprophylaxis should be considered in patients with BMI > 30 kg/m2.
Radiographic Evaluation of Medial Opening-Wedge High Tibial Osteotomy Using a New Internal Fixator with a Wedge-Shaped Spacer Block
Authors: Okimura Shinichiro , Teramoto Atsushi , Watanabe Kota , Nuka Satoshi , Kamiya Tomoaki , Yamashita Toshihiko 
Published: January 2020

AbstractWe developed a new internal fixator: a rigid T-shaped plate with locking screws and wedge-shaped spacer block for high tibial osteotomy. The purpose of the present study was to evaluate the radiographic outcome of opening-wedge high tibial osteotomy (OWHTO) using this new internal fixator. Sixty OWHTOs were performed in patients with medial compartment osteoarthritis and varus deformity (28 males and 23 females). Patients' mean age was 60.4 years. Preoperative and postoperative radiographs were obtained. The paired t-test was used to evaluate the differences over time with respect to radiographic variables. Union of the osteotomy gap was obtained in all patients, and no implant breakage was found. On anterior–posterior radiographs, a significant difference was observed (p < 0.01) between the preoperative and postoperative mean values of femorotibial angles (179.6 ± 3.2 vs. 170.6 ± 2.5 degrees), weight-bearing line ratios (23.8 ± 13.5 vs. 60.5 ± 11.5%), anatomical medial proximal tibial angles (84.8 ± 2.5 vs. 91.0 ± 2.6 degrees), and joint line coverage angles (3.6 ± 2.0 vs. 2.4 ± 1.7 degrees). On lateral radiographs, posterior tibial slopes were 11.5 ± 3.9 degrees preoperatively and 12.2 ± 4.0 degrees postoperatively (p < 0.01), and Insall–Salvati ratios were 1.04 ± 0.12 preoperatively and 1.06 ± 0.13 postoperatively (p = 0.24). Performing OWHTO using a new internal fixator with a wedge-shaped spacer achieves adequate correction of lower limb alignment without implant-related complications. This is a Level IV, case series study.
Posttraumatic Rupture of Branch Pseudoaneurysm of Deep Femoral artery: A Rare Case
Authors: Prasad Rajendra , Luthra Luv , Maruthu Adharsh 
Published: January 2020

Abstract
Introduction Traumatic pseudoaneurysms of deep femoral artery (DFA) are usually seen secondary to sports injuries, postendovascular procedures, trauma to thigh, or after orthopaedic interventions for femur fractures. They usually present as either a pulsatile mass or even as thigh compartment syndrome if not diagnosed early.
Case Report We present a case of a 65-year-old male who was referred for thigh swelling with severe anemia. On angiographic evaluation, patient was diagnosed to have pseudoaneurysm of DFA branch with hematoma in the thigh. Patient underwent an emergency surgery in view of hemodyanamic instability and ligation of ruptured DFA branch pseudoaneurysm.
Conclusion Pseudoaneurysms of the DFA are rare entity and can be asymptomatic or may present with active bleeding in the compartment on rupture. Both surgical and endovascular treatments are available options and mainly depend on the hemodyanamic condition of the patient.
Acute Disseminated Encephalomyelitis followed by Optic Neuritis: A Rare Syndrome of Uncertain Treatment and Prognosis
Authors: Serra Maria , Presicci Anna , Fucci Martina , Margari Mariella , Palumbi Roberto , Peschechera Antonia , Margari Lucia 
Published: January 2020

Abstract
Aim Acute Disseminated Encephalomyelitis followed by optic neuritis (ADEM-ON), first described in 2013, is a rare demyelinating syndrome, typical of the pediatric age. We conducted a mini review of the existing literature, focusing on clinical, laboratory, radiological, therapeutic, and prognostic aspects in order to improve the identification of new cases.
Methods We searched PubMed and Cochrane Library for studies on ADEM-ON between 2013 and 2018.
Results Examination of the reported cases (three case reports and eight observational studies) established the following features. Time between ADEM and ON is highly variable. Almost all patients show antimyelin oligodendrocyte glycoprotein antibody (MOG-abs) seropositivity. High-dose intravenous steroid and plasmapheresis efficacy is reported for the acute phase; oral prednisone and other maintenance drugs may be useful in avoiding relapses. The clinical history may lead to a complete recovery but also to residual deficits.
Conclusion MOG-abs detection strongly supports ADEM-ON diagnosis, confirming this entity as part of MOG-abs spectrum disorder. Owing to the very small number of cases so far reported, predicting clinical evolution is very difficult.
Recurrent Dystonic Crisis and Rhabdomyolysis Treated with Dantrolene in Two Patients with Aromatic L-Amino Acid Decarboxylase Deficiency
Authors: Micallef J. , Stockler-Ipsiroglu S. , van Karnebeek C.D. , Salvarinova-Zivkovic R. , Horvath G. 
Published: January 2020

AbstractAromatic L-amino acid decarboxylase (AADC) deficiency is a rare, autosomal recessive inborn error of metabolism in which several neurotransmitters including serotonin, dopamine, norepinephrine and epinephrine are deficient. Symptoms typically appear in the first year of life and include oculogyric crises and dystonia, hypotonia, and global developmental delay. Dystonia is of particular concern as a dystonic storm can ensue leading to rhabdomyolysis. Rhabdomyolysis can become life-threating and therefore its recognition and prompt management is of significant importance. Here we present two cases of patients with AADC deficiency and a history of dystonic crisis causing rhabdomyolysis. We hypothesize that in addition to the hypodopaminergic, a hypercholinergic state is contributing to the pathophysiology of dystonia in AADC deficiency, as well as to the associated rhabdomyolysis. We were able to prevent rhabdomyolysis in both patients with using Dantrolene and we suggest using a trial of this medication in cases of sustained dystonic crisis in AADC deficiency patients.
Induction Therapy Prior to Surgical Resection for Patients Presenting with Locally Advanced Esthesioneuroblastoma
Authors: Miller Kevin C. , Marinelli John P. , Janus Jeffrey R. , Chintakuntlawar Ashish V. , Foote Robert L. , Link Michael J. , Choby Garret , Van Gompel Jamie J. 
Published: January 2020

AbstractEsthesioneuroblastoma (ENB) is a rare olfactory malignancy that can present with locally advanced disease. At our institution, patients with ENB in whom the treating surgeon believes that a margin-negative resection is initially not achievable are selected to undergo induction with chemotherapy with or without radiotherapy prior to surgery. In a retrospective review of 61 patient records, we identified six patients (10%) treated with this approach. Five of six patients (83%) went on to definitive surgery. Prior to surgery, three of five patients (60%) had a partial response after induction therapy, whereas two of five (40%) had stable disease. Microscopically margin-negative resection was achieved in four of five (80%) of the patients who went on to surgery, while one patient had negative margins on frozen section but microscopically positive margins on permanent section. Three of five patients (60%) recurred after surgery; two of these patients died with recurrent/metastatic ENB. In summary, induction therapy may facilitate margin-negative resection in locally advanced ENB. Given the apparent sensitivity of ENB to chemotherapy and radiotherapy, future prospective studies should investigate the optimal multidisciplinary approach to improve long-term survival in this rare disease.
Video Head Impulse Testing: From Bench to Bedside
Authors: Chen Luke , Halmagyi G. Michael 
Published: January 2020

AbstractOver 30 years ago, the head impulse test (HIT) was measured with search coil recordings and it provided robust evidence for a new test of vestibular function that could detect impairment of a single semicircular canal, that is, the lateral canal. Over the next two decades, the diagnostic spectrum of HIT was expanded to the testing of vertical canals, differentiation of central from peripheral vestibulopathy, and incorporation of visual interaction—the suppressed head impulse. However, HIT measurement was limited to very few specialized laboratories that were able to maintain the time-consuming and expensive operation of the scleral search coil system, which is the gold standard in eye movement recording. The video HIT (vHIT) was validated for the first time over 10 years ago, against the search coils, and its introduction into dizzy clinics worldwide has revolutionized the practice of neuro-otology. Here we review the basic physiology, practical aspects, and clinical application of the vHIT.
Bilateral Vestibular Dysfunction
Authors: Lee Sun-Uk , Kim Hyo-Jung , Kim Ji-Soo 
Published: January 2020

AbstractBilateral vestibular dysfunction (BVD) refers to hypofunction of the vestibular nerves or labyrinths on both sides. Patients with BVD present with dizziness, oscillopsia, and unsteadiness, mostly during locomotion, which worsen in darkness or on uneven ground. Although aminoglycoside ototoxicity, Meniere's disease, infection, and genetic disorders frequently cause BVD, the etiology remains undetermined in up to 50% of the patients. The diagnosis of BVD requires both symptoms and documentation of deficient vestibulo-ocular reflex function using head-impulse, bithermal caloric, and rotatory chair tests. Since various neurologic and systemic disorders may present with BVD, clinicians should be cautious not to overlook the symptoms and signs of central nervous system and systemic involvements. Vestibular rehabilitation, application of vibrotactile and auditory feedbacks, and vestibular prosthesis can aid the patients with BVD along with the correction of the underlying causes.