bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vivo MRI Structural and PET Metabolic Connectivity Study of Dopamine Pathways in Alzheimer’s Disease
Authors: Iaccarino Leonardo , Sala Arianna , Caminiti Silvia Paola , Presotto Luca , Perani Daniela ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: May 2020

Background: Alzheimer’s disease (AD) is characterized by an involvement of brain dopamine (DA) circuitry, the presence of which has been associated with emergence of both neuropsychiatric symptoms and cognitive deficits. Objective: In order to investigate whether and how the DA pathways are involved in the pathophysiology of AD, we assessed by in vivo neuroimaging the structural and metabolic alterations of subcortical and cortical DA pathways and targets. Methods: We included 54 healthy control participants, 53 amyloid-positive subjects with mild cognitive impairment due to AD (MCI-AD), and 60 amyloid-positive patients with probable dementia due to AD (ADD), all with structural 3T MRI and 18F-FDG-PET scans. We assessed MRI-based gray matter reductions in the MCI-AD and ADD groups within an anatomical a priori-defined Nigrostriatal and Mesocorticolimbic DA pathways, followed by 18F-FDG-PET metabolic connectivity analyses to evaluate network-level metabolic connectivity changes. Results: We found significant tissue loss in the Mesocorticolimbic over the Nigrostriatal pathway. Atrophy was evident in the ventral striatum, orbitofrontal cortex, and medial temporal lobe structures, and already plateaued in the MCI-AD stage. Degree of atrophy in Mesocorticolimbic regions positively correlated with the severity of depression, anxiety, and apathy in MCI-AD and ADD subgroups. Additionally, we observed significant alterations of metabolic connectivity between the ventral striatum and fronto-cingulate regions in ADD, but not in MCI-AD. There were no metabolic connectivity changes within the Nigrostriatal pathway. Conclusion: Our cross-sectional data support a clinically-meaningful, yet stage-dependent, involvement of the Mesocorticolimbic system in AD. Longitudinal and clinical correlation studies are needed to further establish the relevance of DA system involvement in AD.
Novel Markers of Angiogenesis in the Setting of Cognitive Impairment and Dementia
Authors: Callahan Christopher M. , Apostolova Liana G. , Gao Sujuan , Risacher Shannon L. , Case Jamie , Saykin Andrew J. , Lane Kathleen A. , Swinford Cecily G. , Yoder Mervin C. 
Published: May 2020

Background: Aberrant angiogenesis may play a role in the development of Alzheimer’s disease and related dementia. Objective: To explore the relationship between angiogenesis activity and evidence of neurodegeneration among older adults. Methods: Cross-sectional study of 49 older adults clinically characterized as cognitively normal, mild cognitive impairment, or early Alzheimer’s disease. In addition to neuroimaging, we completed assays on peripheral blood, including: vascular endothelial growth factor, tumor necrosis factor, fibroblast growth factor, and amyloid-β peptide 40. We used advanced polychromatic flow cytometry to phenotype circulating mononuclear cells to assess angiogenesis activity. Results: Although we documented differences in cognitive performance, structural changes on neuroimaging, and burden of amyloid and tau on positron emission tomography, angiogenesis activity did not vary by group. Interestingly, VEGF levels were shown to be increased among subjects with mild cognitive impairment. In ANCOVA models controlling for age, sex, intracranial volume, and monocyte subpopulations, angiogenesis activity was correlated with increased white matter hyperintensities. Conclusion: We demonstrate a significant association between angiogenesis activity and cerebrovascular disease. To better understand the potential of angiogenesis as an intervention target, longitudinal studies are needed.
Flickering Red-Light Stimulus for Promoting Coherent 40 Hz Neural Oscillation: A Feasibility Study
Authors: Sahin Levent , Figueiro Mariana G. 
Published: May 2020

Background: Coherent 40 Hz (gamma) neural oscillation indicates healthy brain activity and is known to be disrupted in Alzheimer’s disease (AD) patients. 40 Hz entrainment by flickering light is known to significantly attenuate AD pathology in mice. Objective: To demonstrate the feasibility of using a lighting intervention to promote coherent 40 Hz neural oscillation, improved working memory performance, and reduced subjective sleepiness among a population of healthy young adults. If successful, the intervention could be extended to address cognitive impairment associated with mild cognitive impairment and AD. Methods: Nine healthy participants (median age 22 years, five females) were exposed to one of two lighting conditions per session in a within-subjects counterbalanced manner. The study’s two sessions were separated by 1 week. Custom-built light masks provided either a 40 Hz flickering red light (FRL) intervention or a dark control condition (i.e., total darkness, light mask not energized) at participants’ eyes. Data were collected four times per session: pre-exposure, after 25-min exposure, after 50-min exposure, and post-exposure. Each data collection period included a Karolinska Sleepiness Scale report, an electroencephalogram, and working memory ( n-back) auditory performance testing. Results: The FRL intervention induced a significant increase in 40 Hz power and a modest increase in low gamma power. The intervention had no significant impact on working memory performance and subjective sleepiness compared to the control. However, increases in 40 Hz power were significantly correlated with reduced subjective sleepiness. Conclusion: The results clearly demonstrate the feasibility of using a flickering light to increase 40 Hz power.
A reference architecture for plausible Threat Image Projection (TIP) within 3D X-ray computed tomography volumes
Authors: Wang Qian , Megherbi Najla , Breckon Toby P. 
Published: May 2020

BACKGROUND: Threat Image Projection (TIP) is a technique used in X-ray security baggage screening systems that superimposes a threat object signature onto a benign X-ray baggage image in a plausible and realistic manner. It has been shown to be highly effective in evaluating the ongoing performance of human operators, improving their vigilance and performance on threat detection. OBJECTIVE: With the increasing use of 3D Computed Tomography (CT) in aviation security for both hold and cabin baggage screening a significant challenge arises in extending TIP to 3D CT volumes due to the difficulty in 3D CT volume segmentation and the proper insertion location determination. In this paper, we present an approach for 3D TIP in CT volumes targeting realistic and plausible threat object insertion within 3D CT baggage images. METHOD: The proposed approach consists of dual threat (source) and baggage (target) volume segmentation, particle swarm optimisation based insertion determination and metal artefact generation. In our experiments, real baggage data collected from airports are used to generate TIP volumes for evaluation. We also propose a TIP quality score metric to automatically estimate the quality of generated TIP volumes. RESULT: In our experiments with real baggage CT volumes and varying threat items, 90.25% of the generated TIP volumes are graded as good by human evaluation, 7% of them are of medium quality with minor flaws and 2.75% of them are bad. CONCLUSION: Qualitative evaluations on real 3D CT baggage imagery show that our approach is able to generate realistic and plausible TIP which are indiscernible from real CT volumes and the TIP quality scores are consistent with human evaluations.
Reseñas
Authors: Romero Rodríguez José Juan , Trechera Herreros José Luis , Prieto Martínez Fernando , Rodero Franganillo Adolfo , Ariza Montes José Antonio , Margenat Peralta José María 
Published: May 2020

Reseña de las obras de:
FARRÉ, M. Y ALLEPUZ, R. (Ed.), (2001), Globalización y dependencia. Efectos de la mundialización sobre el desarrollo de los pueblos, Lleida, Universitat de Lleida, Centre de Cooperació Internacional, 111 págs.
MARTORELL, J. L. (2000), El guión de vida, Bilbao, Desclée de Brouwer, 219 págs.
ORTEGA HEGG, M. (2001), Transición cultural y cambios religiosos en Nicaragua, Managua, Centro de Análisis Sociocultural, Universidad Centroamericana (UCA), 105 págs.
ORTEGA HEGG, M. (2001), Cultura Política, Gobierno Local y Descentralización. Nicaragua, San Salvador, Facultad Latinoamericana de Ciencias Sociales (FLACSO), 231 págs
VALLÉS, J. M. (2000), Ciencia Política. Una introducción, Barcelona, Ariel, 443 págs.
MARGENAT, J. M. (Ed.), (2000), Escritos del Papa Juan XXIII, Bilbao, Desclée de Brouwer, 384 págs.
MORALES GUTIÉRREZ, A. C. (2000), Arquitectura de sistemas organizativos, Córdoba, Publicaciones ETEA, 404 págs.
POMBO, P. y HERRERA, A. (2001), Los sistemas de garantía para la micro y la PYME en una economía globalizada, Sevilla, Dpeditorial, 1.130 págs.
CASTÓN BOYER, P. y RUIZ BECERRIL, D. (2001), Los Religiosos y los Servicios Sociales en Andalucía, Granada, URPA y Adhara, 77 págs.
DAY, D. (2000), La larga soledad (Autobiografía), Santander, Sal Terrae, 303 págs.
"Cambiar las reglas. Comercio, globalización y lucha contra la pobreza" (Recensión)
Authors: Rodero Franganillo Adolfo 
Published: May 2020

Recensión de la obra de: OXFAM INTERNACIONAL (2002), Cambiar las reglas. Comercio, globalización y lucha contra la pobreza. Barcelona, Ed. Oxfam Internacional, 270 págs.
Reseñas
Authors: Camacho Laraña Ildefonso , Romero Rodríguez José Juan , Velasco Portero María Teresa , Rodero Franganillo Adolfo 
Published: May 2020

VIDAL, M., Ética civil y sociedad democrática. Nueva edición, Bilbao, Desclée de Brouwer, 2002, 294 págs.
JÁUREGUI, R. y GARCÍA DE ANDOIN, C. (eds.), (2001), Tender puentes. PSOE y mundo cristiano, Bilbao, Desclée de Brouwer, 484 págs.
TRILLA, C. (2001), La política de vivienda en una perspectiva europea comparada, Barcelona, Fundación La Caixa, Colección Estudios Sociales, nº 9, 208 págs.
MARZAL, A. (Ed.) (2000), Los Derechos Humanos en el mundo, Barcelona, J.M. Bosch y ESADE–Facultad de Derecho, 214 págs.
GONZÁLEZ CANO, V., (2002), Crédito y endeudamiento en las agriculturas andaluzas, Córdoba, Publicaciones ETEA y Universidad de Córdoba, 312 págs.
MARTÍN, C.; HERCE, J.S.; SOSVILLA–RIVERO, S.; VELÁZQUEZ, F.J. (2001), La ampliación de la Unión Europea. Efectos sobre la economía española, Barcelona, Servicio de Estudios La Caixa, Colección Estudios Económicos, nº 27, 160 págs.
CUBERO SALMERÓN, J.I. (Edición y comentarios) (1999), El libro de agricultura de Al Awam, Málaga, Empresa pública para el Desarrollo Agrario y Pesquero de Andalucía, 985 págs.
PRESUPPOSITION AND ITS TRUTH RELATIONS
Authors: Sopha Diana 
Published: May 2020

Penelitian ini berkonsentrasi pada presuposisi yang terdapat di dalam tulisan karya Ernest Hemingway ‘Indian Camp’. Selain menemukan presuposisi yang ada di dalam kalimat, penelitian ini juga membahas hubungan kebenaran kalimat dengan presuposisinya. Dengan menggunakan metode deskriptif qualitatif, presuposisi pada kalimat dan hubungan kebenaran antara kalimat dan presuposisi kalimat tersebut diidentifikasi. Jika kalimat tersebut benar atau salah maka presuposisi kalimat akan menjadi benar. Namun sebaliknya jika presuposisi kalimat tersebut benar atau salah maka kalimat tersebut tidak dapat menjadi benar atau salah sehingga kalimat tersebut tidak mempunyai nilai kebenaran.
MENINGKATKAN HASIL BELAJAR BAHASA INGGRIS SISWA KELAS VII-5 MELALUI STRATEGI PEMBELAJARAN PENINGKATAN KEMAMPUAN BERFIKIR DI SMP NEGERI 1 PANCUR BATU PADA TAHUN PELAJARAN 2019/2020
Authors: Br Purba Nursyam Hasyim 
Published: May 2020

Tujuan penelitian ini adalah untuk: Meningkatkan hasil belajar siswa kelas VII-5 melalui Strategi Pembelajaran Peningkatan Kemampuan Berfikir di SMP Negeri 1 Pancur Batu pada tahun Pelajaran 2019/2020. Metode yang digunakan dalam penelitian adalah Metode Penelitian Tindakan Kelas dengan menggunakan 2 siklus. Subjek penelitian ini adalah siswa Kelas VII-5 SMP Negeri 1 Pancur Batu sebanyak 32 orang. Instrumen yang digunakan untuk memperoleh data adalah menggunakan test, angket dan observasi. Rentang nilai untuk tes adalah 1-100. Teknik analisis data yang digunakan adalah menggunakan jumlah nilai rata rata siswa, persentase jumlah siswa yang tuntas dan persentase jumlah siswa yang belum tuntas. Hasil Penelitian ini menunjukkan terdapat peningkatan hasil belajar dengan menerapkan Strategi Pembelajaran Peningkatan Kemampuan Berfikir dengan hasil sebagai berikut: (1) Terdapat peningkatan rata-rata hasil belajar siswa, dimana pada tes awal rata-rata hasil belajar siswa adalah 39, pada siklus I meningkatkan menjadi 67,5 kemudian pada siklus II meningkat lagi menjadi 77,81, (2).Terdapat peningkatan jumlah siswa yang tuntas, dimana pada tes awal jumlah siswa yang tuntas hanya 0%, meningkat menjadi 75,0% pada siklus I kemudian meningkat lagi menjadi 87,5% pada siklus II,(3). Terdapat penurunan jumlah siswa yang tidak tuntas, dimana pada tes awal jumlah siswa yang tidak tuntas mencapai 100%, pada siklus I menurun menjadi 25,0% kemudian pada siklus II menurun lagi menjadi 12,5% dengan kata lain hanya 4 siswa saja yang memperoleh nilai 60 dan selebihnya (28) siswa memperoleh nilai di atas 70.
IKTIKAD BAIK DALAM KERJA SAMA ANTARA ASOSIASI BONGKAR MUAT DENGAN KOPERASI TENAGA BONGKAR MUAT UPAYA KARYA
Authors: Moertiono R. Juli 
Published: May 2020

Jenis Penelitian yang digunakan dalam penelitian ini adalah penelitian hukum normatif (normatif research) dengan fokus permasalahan terkait bagaiamana iktikad baik dalam perjanjian kerja sama antara asosiasi bongkar muat dengan koperasi tenaga bongkar muat upaya karya 3) Bagaiamana penyelesaian perselisihan kerja sama antara asosiasi bongkar muat dengan koperasi tenaga bongkar muat upaya karya. Berdasarkan hasil penelitian diketahui bahwa pelaksanaan iktikad baik dalam perjanjian kerja sama antara asosiasi bongkar muat dengan koperasi tenaga bongkar muat upaya karya harus didasarkan pada asas-asas perjanjian diatur dalam KUHPerdata, yang sedikitnya terdapat lima asas yang perlu mendapat perhatian dalam membuat perjanjian: asas kebebasan berkontrak, asas konsensualisme, asas kepastian hukum, asas itikad baik dan asas kepribadian.
IMPLIMENTASI MODEL ADDIE DENGAN PENGGUNAAN ENGLISH ECONOMI TERMS DALAM MENINGKATKAN KEMAMPUAN KOMUNIKASI BERBAHASA INGGRIS PADA SISWA SMA ABDI NEGARA BINJAI
Authors: Dewi Nurmala Nila Afningsih, Debbi Chyntia Ovami, 
Published: May 2020

Penggunaan istilah-istilah ekonomi dalam bahasa inggris (Economi English Terms) merupakan suatu kebutuhan dalam berbahasa yang wajib dimiliki para generasi muda. Perkembangan dan kemajuan ekonomi dunia memaksa kita untuk terus bangkit membenahi diri termasuk dengan kemampuan dalam berbahasa inggris. , khususnya di bidang ekonomi. Pada penelitian ini berusaha menyajikan Model ADDIE dalam penggunaan istilah-istilah ekonomi berbahasa Inggris.. Model ini diperlakukan kepada siswa SMA dimana mereka adalah generasi penerus negeri ini yang akan melanjutkan perjuangan bangsa ini di berbagai bidang termasuk dibidang ekonomi. Peng-Implimentasian model ADDIE dalam pembelajaran bahasa inggris bukan saja untuk meningkatkan kemampuan berbahasa Inggris akan tetapi tujuan utamanya adalah mempersiapkan generasi muda yang siap saing tingkat nasional maupun Internasional, dan sebagai modal tambahan bagi calon Intreprenuer muda. Populasi dan sampel pada penelitian ini adalah Siswa SMA Abdi Negara Binjai.Pada penelitian ini diperlakukannya eksperimen dan survey. Berdasarkan hasil uji F yang dilakukan, diketahui bahwa tingkat signifikansi sebesar 0,000 yang lebih kecil dari 0,05. Berdasarkan hasil ini dapat disimpulkan bahwa variabel independen yaitu Model ADDIE dengan penggunaan Economi English Terms berpengaruh cukup signifikan terhadap peningkatan kemampuan berkomukasi bahasa inggris pada siswa-siswa SMA Abdi Negara.
NILAI KEARIFAN LOKAL DAN UPAYA PEMERTAHANAN BUDAYA “MARSALAP ARI” DALAM MENJALIN SOLIDARITAS ANTAR SESAMA DI DESA PARINGGONAN SEBAGAI BAHAN AJAR PEMBENTUKAN KARAKTER MAHASISWA
Authors: Devinna Riskiana Aritonang Lili Herawati Parapat, 
Published: May 2020

Budaya “Marsalapari” adalah budaya masyarakat yang simbiosis mutualisme. Berdasarkan hasil penelitian budaya “marsalap ari” ini dapat dilihat dari paparan berikut ini. Identitas budaya daerah Paringgonan dengan masyarakat yang membedakan dari budaya lain. Meningkatkan suasana masyarakat yang kondusif. Perekat jiwa solidaritas antar sesama masyarakat alam hidup multikultural, mencegah konflik antar sesasama bermasyarakat. Upaya pemertahanan budaya terhadap perubahan zaman tetap terjaga sehingga dapat dijadikan sebagai bahan ajar dan pembelajaran sekaligus pembentuk karakter manusia. Metode penelitian deskriptif. Analisis data menggunakan dengan cara reduksi, penyajian, dan penarikan kesimpulan. Informan penelitian adalah masyarakat Paringgonan. Berdasarkan hasil penelitian diketahui bahawa upanya masyarakat dalam mempertahankan budaya lokal di Desa paringgonan diketahui 85 % dapat dilihat dari keseluruahn karakter tolong menolong antar sesame masyarakat yang secara bergantian untuk menyelesaikan pekerjaan bersama, disawah dan diladang. Kerukunan, kerjasama dalam masyarakan terjalin dan dapat dibertahan. Dengan demikian “Nilai Kearifan Lokal Dan Upaya Pemertahanan Budaya “Marsalap Ari” Dalam Menjalin Solidaritas Antar Sesama dapat dijadikan Sebagai Bahan Ajar Pembentukan Karakter Mahasiswa.
Penyuluhan Melalui Media Tokoh Adat Bayan (WETUTELU) Terhadap Pengetahuan Ibu Balita Tentang Pesan Gizi Seimbang
Authors: Swidari Denda , Abdi Lalu Khairul , Laraeni Yuli , Salam Abdul 
Published: May 2020

Background : Factors of education and knowledge mothers of toddlers can influence nutritional status. One effort to improve nutritional status is to increase knowledge about nutrition with nutrition counseling. Knowledge can be influenced by education, people who are highly educated will have broader knowledge and have openness to accept new things. While people with low education tend to have old thinking patterns and are less open to new things including a strong area of customs and traditional. One of the ways to influence the mindset of community with these condition is to use a communication facilitator who is believed to be a role model for the community. So, in this reseach the role of cultural figure was used, so that people receive more material. Objectives : Knowing the influence of educatuin by cultural figure on knowledge of mothers of toddlers about balance nutritional massages. Methods : This Research is pre-experimental study. Which allows testing of changes that occur after the intervention. This research design was used one grup pretest-posttest design. Results : there is an increase in knowledge in the form of difference in scores from pretest to posttest. Based on the result of the analysis using wilcoxon, the influence of education by cultural figure on the knowledge of mothers of toddlers about balance nutritional massages obtained p=0.00 atau p<0.05 meaning there is influence. Conclusion : There is the influence of education by cultural figure on knowledge of mothers of toddlers about balanced nutrition massages.
Pengaruh Komik Isi Piringku terhadap Asupan Karbohidrat dan Protein pada Anak Gizi Lebih
Authors: Darni Joyeti , Agustina Eva 
Published: May 2020

Background: Communication, Information and Education (IEC) of nutrition for school children can shape children's eating habits from an early age in order to achieve a better individual situation in the future. Comics are able to display simple stories and writing in colloquial so that they are easy to understand. Research Methods. This is a quasi experimental study with control group pretest-posttest design. Subjects were taken with a simple random sample of 60 students who were divided into two groups, the first group was given education with comic Isi Piringku and the second group was given education without comic Isi Piringku. The carbohydrate and protein intake data in two groups were analyzed using the paired t-test. Research Result. The analysis showed that the highest protein intake enhancement occurred in the treatment group with a delta of 16.7 g, while the control group was 6.2 points. The carbohydrate intake before treatment was 191,9 g and increased after given comic Isi Piringku by 193,4 g. The results of different test showed that there were significant differences in the enhancement of protein intake before and after the provision of nutrition education between the control group and the treatment group with p value <0.05, carbohydrate intake was not significantly different before and after treatment.
Pengaruh Penambahan Wortel dan Buncis terhadap Sifat Organoleptik dan Daya Terima Nugget Sitelcis
Authors: Sulastri Rima , Darawati Made , Jaya Ketut Swirya 
Published: May 2020

Background : Utilization of Rice Snails (Pila ampullacea) in the Making of Nugget with the Addition of Vitamins and Minerals (Carrots and Beans) which Contain High Protein to Overcome Nutritional Problems of PEM (Protein Energy Lack) in Toddler Children. Objectives : To determine the effect of carrot and bean addition on organoleptic properties and acceptability of toddlers on the SITELCIS nugget (snail carrot snail). Research Methods: This study used an experimental method in the laboratory with a Completely Randomized Design (CRD) of 1 factor, namely the addition of Carrots and Beans. Performed 5 levels of treatment and repetition 3 times with the addition of different Carrots and Beans. Organoleptic Properties Test Using the hedonic test method. Research Results : Anova Statistical Test Results on Panelists (Tukey) Effect of Carrots and Beans on Flavor (p <0.05). While the parameters of color, aroma and texture have no effect or (p> 0.05). The most preferred treatment for the highest average score is the taste parameter in treatment t4 with the addition of carrots and beans 20%. Conclusion : Based on the results of the test results of the acceptance of the SITELCIS Nugget in toddlers aged 4-5 years at the level of treatment t4 with the addition of carrots and beans (20%). From the results of the acceptance of children under five with given per serving of nuggets, the intake of good intake (≥ 80%) as many as 22 people, while the receiving power is less (<80%), which is as many as 3 people.
Penyuluhan Dan Pendampingan Pencegahan Pernikahan Usia Dini Dengan Model Deep Dialogue Problem Solving Di Madrasah Aliyah Walisongo Gending Probolinggo
Authors: Salamah Umi 
Published: May 2020

The phenomenon of child marriage in Gending Probolinggo is similar to Madurese. The majority of population, is descendants of Madura, made the baligh as the determinant of marriage. This community service aims to prevent the occurrence of child marriage. The import-of-prevention of effort, because child is vulnerable to reproduction, mental stress, and barriers to social interaction. In connection with that, the partisans who were subjected to counseling were MA and MTs Walisongo students, teachers, religious eaders / Kyai, and parents of students. The approach used was social, communication and personal approach with deep dialogue problem solving models. Based on these targets and approaches, was concluded (1) the same way of prevention and child care between persons and participants, (2) forms of collaboration and prevention of child labor and resources communication between participants and (3) agreement to open communication between participants and resource persons.