bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rocking the boat while staying in it: connecting ends and means in radical community work
Authors: Ardle Oonagh Mc 
Published: June 2020

AbstractAt a time when the term ‘radical’ is predominantly associated with intolerance and violence, this article explicitly interrogates its meaning and application in community development praxis. Based on a qualitative inquiry, influenced by community development principles, community workers with rich experience at both micro- and macro-levels in Ireland were interviewed individually, then collectively to elicit their perspectives on the possibilities and challenges for radical community work in Ireland. While specifically located, its conclusions have relevance for community work and community development globally.Findings show that being a professional and a radical are not incompatible. Some radical community workers recognize their dual role in service of the state and their obligation to work with others to change it. Acknowledging that marginalized communities do not have the access to power available to more privileged communities necessitates strategies to maximize influence. At the same time, there is an intimate connection between the methods used to transform society and the nature of the subsequent society. As workers accountable to communities, funders and the profession itself, the strategies engaged with and tactics adopted warrant careful consideration.This article seeks to challenge the dichotomy of either conflict or consensus approaches as overly simplistic. Its suggests that some community workers can hold a radical agenda and conflictual ideology while pro-actively engaging with decision-makers who, although part of systems, which perpetuate inequality, can also be agents of change.
The Effectiveness of Individual and Environmental Infection Control Measures in Reducing the Transmission of Mycobacterium tuberculosis: A Systematic Review
Authors: Fox Greg J , Redwood Lisa , Chang Vicky , Ho Jennifer 
Published: June 2020

Abstract

Background
Transmission of Mycobacterium tuberculosis in healthcare settings is a preventable driver of the global tuberculosis epidemic. We aimed to assess the evidence for infection control interventions, including cough etiquette, engineering and personal respiratory protection measures, to prevent transmission of M. tuberculosis in healthcare settings.

Methods
Three independent systematic reviews were performed using 6 databases and clinical trials websites. Randomized trials, cohort studies, before-after studies, and case-control studies were included. Searches were performed for controlled studies evaluating respiratory hygiene, engineering, and personal respiratory protection measures. Outcome measures included the incidence of tuberculosis infection and disease. Studies involving transmission to either humans or animals were included.

Results
Evaluation of respiratory hygiene and cough etiquette interventions identified 4 human studies, with 22 855 participants, and 1 guinea pig study. Studies in humans evaluated the effects of multiple concurrent interventions. Patient use of surgical masks reduced infection by 14.8%, and tuberculosis disease was reduced by between 0.5% and 28.9%. Engineering and environmental interventions were evaluated in 10 studies of humans, including 31 776 human participants, and 2 guinea pig studies. Mechanical ventilation was associated with between 2.9% and 14% less infection. Nine studies of personal respiratory protection were included, including 33 913 participants. Infection was reduced by between 0% and 14.8% in studies where particulate respirators were used. The quality of included studies was assessed as low.

Conclusions
Respiratory hygiene, engineering, and environmental infection controls and personal respiratory protection interventions were associated with reduced transmission of M. tuberculosis and reduced tuberculosis disease in healthcare settings.
HOME2 Study: Household Versus Personalized Decolonization in Households of Children With Methicillin-Resistant Staphylococcus aureus Skin and Soft Tissue Infection—A Randomized Clinical Trial
Authors: Hogan Patrick G , Parrish Katelyn L , Mork Ryan L , Boyle Mary G , Muenks Carol E , Thompson Ryley M , Morelli John J , Sullivan Melanie L , Hunstad David A , Bubeck Wardenburg Juliane , Rzhetsky Andrey , Gehlert Sarah J , Burnham Carey-Ann D , Fritz Stephanie A 
Published: June 2020

Abstract

Background
A household approach to decolonization decreases skin and soft tissue infection (SSTI) incidence, though this is burdensome and costly. As prior SSTI increases risk for SSTI, we hypothesized that the effectiveness of decolonization measures to prevent SSTI when targeted to household members with prior year SSTI would be noninferior to decolonizing all household members.

Methods
Upon completion of our 12-month observational Household Observation of Methicillin-resistant Staphylococcus aureus in the Environment (HOME) study, 102 households were enrolled in HOME2, a 12-month, randomized noninferiority trial. Pediatric index patients with community-associated methicillin-resistant Staphylococcus aureus (MRSA) SSTI, their household contacts, and pets were enrolled. Households were randomized 1:1 to the personalized (decolonization performed only by household members who experienced SSTI during the HOME study) or household (decolonization performed by all household members) approaches. The 5-day regimen included hygiene education, twice-daily intranasal mupirocin, and daily bleach-water baths. At 5 follow-up visits in participants’ homes, swabs to detect S. aureus were collected from participants, environmental surfaces, and pets; incident SSTIs were ascertained.

Results
Noninferiority of the personalized approach was established for the primary outcome 3-month cumulative SSTI: 23 of 212 (10.8%) participants reported SSTI in household approach households, while 23 of 236 (9.7%) participants reported SSTI in personalized approach households (difference in proportions, −1.1% [95% confidence interval, −6.7% to 4.5%]). In multivariable analyses, prior year SSTI and baseline MRSA colonization were associated with cumulative SSTI.

Conclusions
The personalized approach was noninferior to the household approach in preventing SSTI. Future studies should interrogate longer durations of decolonization and/or decontamination of the household environment to reduce household MRSA burden.

Clinical Trials Registration
NCT01814371.
Delamanid Resistance: Update and Clinical Management
Authors: Nguyen Thi Van Anh , Anthony Richard M , Cao Thi Thu Huyen , Bañuls Anne-Laure , Nguyen Van Anh Thi , Vu Dinh Hoa , Nguyen Nhung Viet , Alffenaar Jan-Willem C 
Published: June 2020

Abstract
Delamanid, a-first-in-class bicyclic nitroimidazole, was recently approved for multidrug-resistant tuberculosis treatment. Pitted against the hope for improving treatment outcomes is the threat of the rapid resistance emergence. This review provides information on the mechanisms of action, resistance emergence, and drug susceptibility testing (DST) for delamanid. Delamanid resistance has already been reported in both in vitro experiments and clinical settings. Although mutations conferring delamanid resistance have been identified in fbiA, fbiB, fbiC, ddn, and fgd1 genes of Mycobacterium tuberculosis, knowledge about the molecular resistance mechanisms is limited, and there remains no standardized DST method. The rapid acquisition of delamanid resistance emphasizes the need for optimal use of new drugs, the need for drug resistance surveillance, and a comprehensive understanding of drug resistance mechanisms. Further studies are necessary to investigate genetic and phenotypic changes that determine clinically relevant delamanid resistance to help develop a rapid delamanid DST.
Two-Factor Decryption: A Better Way to Protect Data Security and Privacy
Authors: Cui Hui , Paulet Russell , Nepal Surya , Yi Xun , Mbimbi Butrus 
Published: June 2020

Abstract
Biometric information is unique to a human, so it would be desirable to use the biometric characteristic as the private key in a cryptographic system to protect data security and privacy. In this paper, we introduce a notion called two-factor decryption (TFD). Informally speaking, a TFD scheme is a variant of the public-key encryption (PKE) scheme. In a TFD scheme, messages are encrypted under public keys as that in a standard PKE scheme, but both private keys (i.e. the first factor) and biometric inputs (i.e. the second factor) are required to decrypt the ciphertexts and obtain the underlying plaintexts. We first describe a framework of TFD, and then define a formal security model for TFD. Thereafter, we present a generic construction on TFD based on the cryptographic primitives of linear sketch and functional encryption (FE) with certain properties and analyse its security. In addition, we give instantiations of TFD by applying concrete FE schemes into the generic construction and show their applications.
Transcatheter aortic valve implantation in patients with a left ventricular assist device: a word of caution
Authors: Ali Jason , Catarino Pedro , Abu-Omar Yasir 
Published: June 2020

Abstract
We describe a patient with a HeartMate 3 left ventricular assist device in whom we attempted transcatheter aortic valve implantation for severe aortic regurgitation. The valve migrated into the left ventricle and lodged on the left ventricular assist device inflow cannula. Caution should be exercised when considering the use of transcatheter aortic valve implantation in patients with an implanted left ventricular assist device, with pure aortic regurgitation.
A comparative environmental life cycle assessment of hatchery, cultivation, and preservation of the kelpSaccharina latissima
Authors: Thomas J -B E , Sodré Ribeiro M , Potting J , Cervin G , Nylund G M , Olsson J , Albers E , Undeland I , Pavia H , Gröndahl F 
Published: June 2020

AbstractSeaweed cultivation and processing industries could contribute to sustainable blue growth and the European bioeconomy. This article contributes a case study evaluation of environmental sustainability of preserved brown seaweed Saccharina latissima by means of environmental life cycle assessment of a pilot facility in Sweden. The study accounts for nutrient bioremediation and carbon capture and includes two alternative hatchery processes, a 2-ha longline cultivation, and four alternative preservation methods (hang-drying outdoors, heated air-cabinet drying, ensiling, and freezing). The study found that as a result of carbon capture and nitrogen and phosphorus uptake (bioremediation) by seaweed, more CO2 and PO4 equivalents are (temporarily) absorbed than emitted by the supply chain. The extent of emissions is most affected by preservation methods undertaken. Impact profiles of the supply chain show that the greatest impact shares result from freezing and air-cabinet drying, both the two most energy-intensive processes, followed by the cultivation infrastructure, highlighting strategic optimization opportunities. Hatchery processes, harvesting, and the low-energy ensilage and hang-drying outdoors were found to have relatively small impact shares. These findings presage the environmentally friendliness of seaweed-based products by documenting their potential to mitigate eutrophication and climate change, even when taking a life cycle perspective.
A multiplex assay for characterization of antimicrobial resistance in Neisseria gonorrhoeae using multi-PCR coupled with mass spectrometry
Authors: Li Yamei , Xiu Leshan , Liu Jingwei , Zhang Chi , Wang Feng , Yin Yueping , Peng Junping 
Published: June 2020

Abstract

Background
Complicated mechanisms and variable determinants related to drug resistance pose a major challenge to obtain comprehensive antimicrobial resistance (AMR) profiles of Neisseria gonorrhoeae. Meanwhile, cephalosporin-resistant mosaic penA alleles have been reported worldwide. Therefore, it is urgent to monitor the expansion of cephalosporin-resistant mosaic penA alleles.

Objectives
To develop a comprehensive high-throughput method to efficiently screen AMR determinants.

Methods
We developed a method based on multiplex PCR with MALDI-TOF MS, which can simultaneously screen for 24 mutations associated with multiple antimicrobial agents in 19 gonococcal AMR loci (NG-AMR-MS). The performance of the NG-AMR-MS method was assessed by testing 454 N. gonorrhoeae isolates with known MICs of six antibiotics, eight non-gonococcal Neisseria strains, 214 clinical samples and three plasmids with a confirmed mosaic penA allele.

Results
The results show that NG-AMR-MS had a specificity of 100% with a sensitivity as low as 10 copies per reaction (except for PorB A121D/N/G, 100 copies per reaction). For clinical samples with gonococcal load &gt;5 copies/μL, the method can accurately identify 20 AMR mutations. In addition, the method successfully detected specific cephalosporin-resistant strains with the A311V mutation in the penA allele.

Conclusions
Our high-throughput method can provide comprehensive AMR profiles within a multiplex format. Furthermore, the method can be directly applied to screening for AMR among clinical samples, serving as an effective tool for overall monitoring of N. gonorrhoeae AMR and also provides a powerful means to comprehensively improve the level of monitoring.
Dried yeast cell walls high in beta-glucan and mannan-oligosaccharides positively affect microbial composition and activity in the canine gastrointestinal tract in vitro
Authors: Van den Abbeele Pieter , Duysburgh Cindy , Rakebrandt Maike , Marzorati Massimo 
Published: June 2020

AbstractThe outer cell wall of yeast is characterized by high levels of β-glucans and mannan-oligosaccharides (MOS), which have been linked with beneficial effects on intestinal health and immune status in dogs. In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota. The S. cerevisiae-based product was tested at three different dosages, i.e., 0.5, 1.0, and 2.0 g/d. A dose-dependent fermentation pattern was observed along the entire length of the colon, as shown by the increased production of the health-related acetate, propionate, and butyrate for the three concentrations tested (0.5, 1.0, and 2.0 g/d). A consistent finding for all three tested concentrations was the increased propionate production (P &lt; 0.05) in the simulated proximal and distal colon. These changes in terms of fermentative metabolites could be linked to specific microbial alterations at the family level, such as the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product. Other consistent changes in community composition upon repeated exposure included the decrease in the Enterobacteriaceae and the Fusobacteriaceae families, which both contain several potentially opportunistic pathogens. Altogether, the generated data support a possible health-promoting role of a product high in β-glucans and MOS when supplemented to the dogs’ diet.
Comprehensive analysis of the transient X-ray pulsar MAXI J1409−619
Authors: Dönmez Ç K , Serim M M , İnam S Ç , Şahiner Ş , Serim D , Baykal A 
Published: June 2020

ABSTRACT
We probe the properties of the transient X-ray pulsar MAXI J1409−619 through RXTE and Swift follow-up observations of the outburst in 2010. We are able to phase-connect the pulse arrival times for the 25 d episode during the outburst. We suggest that either an orbital model (with Porb ≃ 14.7(4) d) or a noise process due to random torque fluctuations (with Sr ≈ 1.3 × 10−18 Hz2 s−2 Hz−1) is plausible to describe the residuals of the timing solution. The frequency derivatives indicate a positive torque–luminosity correlation, which implies temporary accretion disc formation during the outburst. We also discover several quasi-periodic oscillations in company with their harmonics whose centroid frequencies decrease as the source flux decays. The variation of the pulsed fraction and spectral power-law index of the source with X-ray flux is interpreted as the sign of transition from a critical to a sub-critical accretion regime at the critical luminosity within the range of 6 × 1037–1.2 × 1038 erg s−1. Using pulse-phase-resolved spectroscopy, we show that the phases with higher flux tend to have lower photon indices, indicating that the polar regions produce spectrally harder emission.
Chemical abundances in active galaxies
Authors: Flury Sophia R , Moran Edward C 
Published: June 2020

ABSTRACT
The Sloan Digital Sky Survey (SDSS) has proved to be a powerful resource for understanding the physical properties and chemical composition of star-forming galaxies in the local Universe. The SDSS population of active galactic nuclei (AGNs) remains as of yet less explored in this capacity. To extend the rigorous study of H ii regions in the SDSS to AGNs, we adapt methods for computing direct-method chemical abundances for application to the narrow-line regions (NLR) of AGNs. By accounting for triply ionized oxygen, we are able to more completely estimate the total oxygen abundance. We find a strong correlation between electron temperature and oxygen abundance due to collisional cooling by metals. Furthermore, we find that nitrogen and oxygen abundances in AGNs are strongly correlated. From the metal–temperature relation and the coupling of nitrogen and oxygen abundances, we develop a new, empirically and physically motivated method for determining chemical abundances from the strong emission lines commonly employed in flux-ratio diagnostic diagrams (BPT diagrams). Our approach, which for AGNs reduces to a single equation based on the BPT line ratios, consistently recovers direct-method abundances over a 1.5 dex range in oxygen abundance with an rms uncertainty of 0.18 dex. We have determined metallicities for thousands of AGNs in the SDSS, and in the process have discovered an ionization-related discriminator for Seyfert and LINER galaxies.
Revealing the intermediate-mass black hole at the heart of the dwarf galaxy NGC 404 with sub-parsec resolution ALMA observations
Authors: Davis Timothy A , Nguyen Dieu D , Seth Anil C , Greene Jenny E , Nyland Kristina , Barth Aaron J , Bureau Martin , Cappellari Michele , den Brok Mark , Iguchi Satoru , Lelli Federico , Liu Lijie , Neumayer Nadine , North Eve V , Onishi Kyoko , Sarzi Marc , Smith Mark D , Williams Thomas G 
Published: June 2020

ABSTRACT
We estimate the mass of the intermediate-mass black hole at the heart of the dwarf elliptical galaxy NGC 404 using Atacama Large Millimetre/submillimetre Array (ALMA) observations of the molecular interstellar medium at an unprecedented linear resolution of ≈0.5 pc, in combination with existing stellar kinematic information. These ALMA observations reveal a central disc/torus of molecular gas clearly rotating around the black hole. This disc is surrounded by a morphologically and kinematically complex flocculent distribution of molecular clouds, that we resolve in detail. Continuum emission is detected from the central parts of NGC 404, likely arising from the Rayleigh–Jeans tail of emission from dust around the nucleus, and potentially from dusty massive star-forming clumps at discrete locations in the disc. Several dynamical measurements of the black hole mass in this system have been made in the past, but they do not agree. We show here that both the observed molecular gas and stellar kinematics independently require a ≈5 × 105 M⊙ black hole once we include the contribution of the molecular gas to the potential. Our best estimate comes from the high-resolution molecular gas kinematics, suggesting the black hole mass of this system is 5.5$^{+4.1}_{-3.8}\times 10^5$ M⊙ (at the 99 per cent confidence level), in good agreement with our revised stellar kinematic measurement and broadly consistent with extrapolations from the black hole mass–velocity dispersion and black hole mass–bulge mass relations. This highlights the need to accurately determine the mass and distribution of each dynamically important component around intermediate-mass black holes when attempting to estimate their masses.
Bayesian approach to constraining the properties of ionized bubbles during reionization
Authors: Ghara Raghunath , Choudhury T Roy 
Published: June 2020

ABSTRACT
A possible way to study the reionization of cosmic hydrogen is by observing the large ionized regions (bubbles) around bright individual sources, e.g. quasars, using the redshifted 21 cm signal. It has already been shown that matched filter-based methods are not only able to detect the weak 21 cm signal from these bubbles but also aid in constraining their properties. In this work, we extend the previous studies to develop a rigorous Bayesian framework to explore the possibility of constraining the parameters that characterize the bubbles. To check the accuracy with which we can recover the bubble parameters, we apply our method on mock observations appropriate for the upcoming SKA1-low. For a region of size ≳50 cMpc around a typical quasar at redshift 7, we find that ≈20 h of integration with SKA1-low will be able to constrain the size and location of the bubbles, as well as the difference in the neutral hydrogen fraction inside and outside the bubble, with $\lesssim 10$ per cent precision. The recovery of the parameters are more precise and the signal-to-noise ratio of the detected signal is higher when the bubble sizes are larger and their shapes are close to spherical. Our method can be useful in identifying regions in the observed field that contain large ionized regions and hence are interesting for following up with deeper integration times.
Cosmic variance of z &gt; 7 galaxies: prediction from bluetides
Authors: Bhowmick Aklant K , Somerville Rachel S , Di Matteo Tiziana , Wilkins Stephen , Feng Yu , Tenneti Ananth 
Published: June 2020

ABSTRACT
In the coming decade, a new generation of telescopes, including JWST and WFIRST, will probe the period of the formation of first galaxies and quasars, and open up the last frontier for structure formation. Recent simulations and observations have suggested that these galaxies are strongly clustered (with large-scale bias ≳6), and therefore have significant cosmic variance. In this work, we use bluetides, the largest volume cosmological simulation of galaxy formation, to directly estimate the cosmic variance for current and upcoming surveys. Given its resolution and volume, bluetides can probe the bias and cosmic variance of z &gt; 7 galaxies between magnitude MUV ∼ −16 and MUV ∼ −22 over survey areas ∼0.1 arcmin2 to ∼10 deg2. Within this regime, the cosmic variance decreases with survey area/ volume as a power law with exponents between ∼−0.25 and ∼−0.45. For the planned 10 deg2 field of WFIRST, the cosmic variance is between $3{{\ \rm per\ cent}}$ and $10{{\ \rm per\ cent}}$. Upcoming JWST medium/ deep surveys with areas up to A ∼ 100 arcmin2 will have cosmic variance ranging from ${\sim}20\,\mathrm{ to}\,50{{\ \rm per\ cent}}$. Lensed surveys have the highest cosmic variance ${\gtrsim}40{{\ \rm per\ cent}}$; the cosmic variance of MUV ≲ −16 galaxies is ${\lesssim}100{{\ \rm per\ cent}}$ up to z ∼ 11. At higher redshifts such as z ∼ 12 (14), effective volumes of ≳ (8 Mpc h−1)3 (≳(12 Mpc h−1)3) are required to limit the cosmic variance to within $100{{\ \rm per\ cent}}$. Finally, we find that cosmic variance is larger than Poisson variance and forms the dominant component of the overall uncertainty in all current and upcoming surveys. We present our calculations in the form of simple fitting functions and an online cosmic variance calculator (CV_AT_COSMIC_DAWN) that we publicly release.