bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Language Development Via FOXP2 in Autism Spectrum Disorder: A Review
Authors: Chen Panpan , Li Zhongying , Li Yanfei , Ahmad Syed S. , Kamal Mohammad A. , Huo Xiao 
Published: September 2020

Background:An increasing number of newborn children in numerous nations are enrolled in early childhood education programs, and instructors, in this way, assume a focal job in invigorating language improvement in these youthful kids. Kids with language issues are found to have a higher risk for future scholarly challenges and learning inabilities. Language advancement among kids is an intricate procedure and vital for correspondence. The shortcomings in the utilization of grammatical structures may lessen the useful utilization of language for verbally expressive kids with autism spectrum disorder and exacerbate troubles with academic and social expertise advancement.Results:FOXP2, the single principal gene connected to a speech and language issue, is significant for the right execution of complex motor behaviors used for speech. In any case, changes in FOXP2 lead to a speech/language issue portrayed by childhood apraxia of speech. These days, language learning is fundamentally required for kids who need to move to different nations to pursue the instructive frameworks and be helpful individuals or residents of those nations.Conclusion:The purpose of this study was to explore the role of FOXP2 in language disorder and its management for children’s language and communication development.
Synthesis, Antimicrobial Evaluation and Docking Study of Novel Thiosemicarbazone Clubbed with 1,2,3-Triazoles
Authors: Badar Adinath D. , Sulakhe Shubham M. , Muluk Mahesh B. , Rehman Naziya N. M. A. , Dixit Prashant P. , Choudhari Prafulla B. , Bondle Giribala M. , Haval Kishan P. 
Published: September 2020

Background:
Thiosemicarbazone, 1,2,3-triazole and their derivatives received great
pharmaceutical importance due to their prominent biological activities. In the present study, the
molecular hybrid thiosemicarbazone-1,2,3-triazoles derivatives were synthesized and screened for
their antimicrobial activities.

Methods:
A series of thiosemicarbazone clubbed with 1,2,3-triazole derivatives were synthesized
via click chemistry approach in good yields. The structures of synthesized compounds were assigned
by their spectral data. The in vitro antimicrobial activity was performed by the agar well diffusion
method. A molecular docking study was performed to identify the possible mode of action
of synthesized derivatives.

Results:
The compounds 5d, 5h, 5i and 5k exhibited excellent antimicrobial activities against both
antibacterial and antifungal pathogens. The active thiosemicarbazone-1,2,3-triazole derivatives
showed excellent binding affinity towards DNA gyrase.

Conclusion:
The molecular hybrid thiosemicarbazone-1,2,3-triazole derivatives were synthesized.
The newly synthesized compounds were evaluated for their antimicrobial activities. Few of the
thiosemicarbazone-1,2,3-triazoles derivatives have exhibited good antimicrobial activities. They
have shown excellent binding affinity towards DNA gyrase.
Design and Optimization of Chronotherapeutic Dosage Form for the Treatment of Angina Pectoris
Authors: Singh Rupali , Malviya Rishabha 
Published: September 2020

Background:
The chronotherapy concept attains considerable focus towards itself due
to its pulsatile fashion rather than continuous delivery. The delivery of the right amount of drug to
the target organ at the most appropriate time is fulfilled by using the chronotherapeutic dosage
form.

Aim:
The present study aims to develop and evaluate a chronotherapeutic drug delivery system by
using natural polymer for time-specific drug delivery at the target site.

Methods:
Tamarind seed polysaccharide was extracted and used in the preparation of core tablets.
Nine formulations of core tablets were prepared with nifedipine at 5 tonnes of pressure on a 6 mm
punch. The core tablets were prepared by using the compression coating method. The three batches
F1, F2, and F3 were prepared by using tamarind gum in different concentrations i.e., 45%,
22.5%,and 67.5%, respectively, and compressed at 8 tonnes of pressure on 12 mm of punch. The finally
compressed tablet was coated with different concentrations of ethyl cellulose in which isopropyl
alcohol was used as a solvent. In a controlled medium, a stability study was performed to
evaluate the physical appearance, drug content, and release of the prepared core tablet.

Results and Discussion:
All the nine formulations of tablets were prepared successfully and the
evaluation studies (thickness, weight variation, hardness, friability, etc.) revealed that all the formulations
were within the official range. The release study of the drug revealed that the formulation
F7 containing 67.5% of tamarind polymer, coated with 2%, 4%, and 5% of ethylcellulose solution
released 59.68 ± 1.03% (Q50%) drug within 5 h whereas 87.09 ± 2.08% (Q80%) within 6 h and 97.74
± 2.19% of the drug was released within 12 h. The formulation F7 was found to be more effective
as it released the maximum amount of drug in a short period as compared to other formulations.

Conclusion:
The coating of core tablets allowed to prepare pharmaceutical dosage form for timespecific
drug delivery. These chronotherapeutic core tablets can be used for the treatment of angina
pectoris and hypertension, etc.
Effectiveness of Individual Real-Time Video Counseling on Smoking, Nutrition, Alcohol, Physical Activity, and Obesity Health Risks: Systematic Review
Authors: Byaruhanga Judith , Atorkey Prince , McLaughlin Matthew , Brown Alison , Byrnes Emma , Paul Christine , Wiggers John , Tzelepis Flora 
Published: September 2020

Background
Real-time video communication technology allows virtual face-to-face interactions between the provider and the user, and can be used to modify risk factors for smoking, nutrition, alcohol consumption, physical activity, and obesity. No systematic reviews have examined the effectiveness of individual real-time video counseling for addressing each of the risk factors for smoking, nutrition, alcohol consumption, physical activity, and obesity.

Objective
This systematic review aims to examine the effectiveness of individually delivered real-time video counseling on risk factors for smoking, nutrition, alcohol consumption, physical activity, and obesity.

Methods
The MEDLINE (Medical Literature Analysis and Retrieval System Online), EMBASE (Excerpta Medica Database), PsycINFO, Cochrane Register of Controlled Trials, and Scopus databases were searched for eligible studies published up to November 21, 2019. Eligible studies were randomized or cluster randomized trials that tested the effectiveness of individual real-time video communication interventions on smoking, nutrition, alcohol, physical activity, and obesity in any population or setting; the comparator was a no-intervention control group or any other mode of support (eg, telephone); and an English-language publication.

Results
A total of 13 studies were eligible. Four studies targeted smoking, 3 alcohol, 3 physical activity, and 3 obesity. In 2 of the physical activity studies, real-time video counseling was found to significantly increase physical activity when compared with usual care at week 9 and after 5 years. Two obesity studies found a significant change in BMI between a video counseling and a documents group, with significantly greater weight loss in the video counseling group than the in-person as well as the control groups. One study found that those in the video counseling group were significantly more likely than those in the telephone counseling group to achieve smoking cessation. The remaining studies found no significant differences between video counseling and telephone counseling or face-to-face counseling for smoking cessation, video counseling and face-to-face treatment on alcohol consumption, video counseling and no counseling for physical activity, and video counseling and face-to-face treatment on BMI. The global methodological quality rating was moderate in 1 physical activity study, whereas 12 studies had a weak global rating.

Conclusions
Video counseling is potentially more effective than a control group or other modes of support in addressing physical inactivity and obesity and is not less effective in modifying smoking and alcohol consumption. Further research is required to determine the relative benefits of video counseling in terms of other policy and practice decision-making factors such as costs and feasibility.
Secondary Impact of Social Media via Text Message Screening for Type 2 Diabetes Risk in Kuwait: Survey Study
Authors: Alqabandi Naeema , Al-Ozairi Ebaa , Ahmed Adel , Ross Edgar L , Jamison Robert N 
Published: September 2020

Background
Type 2 diabetes mellitus (T2DM) is an international problem of alarming epidemic proportions. T2DM can develop due to multiple factors, and it usually begins with prediabetes. Fortunately, this disease can be prevented by following a healthy lifestyle. However, many health care systems fail to properly educate the public on disease prevention and to offer support in embracing behavioral interventions to prevent diabetes. SMS messaging has been combined with cost-effective ways to reach out to the population at risk for medical comorbidities. To our knowledge, the use of nationwide SMS messaging in the Middle East as a screening tool to identify individuals who might be at risk of developing T2DM has not been reported in the literature.

Objective
The primary aim of this study was to assess the feasibility of conducting a series of SMS messaging campaigns directed at random smartphone users in Kuwait for the detection and prevention of T2DM. It was predicted that 1% of those receiving the text message would find it relevant and participate in the study. The secondary aim of this study was to assess the incidence of participation of those who were forwarded the initial text message by family members and friends.

Methods
In this study, 5 separate text message screening campaigns were launched inviting recipients to answer 6 questions to determine the risk of developing T2DM. If subjects agreed to participate, a link to the prediabetes screening test devised by the Centers for Disease Control and Prevention was automatically transmitted to their mobile devices. Those identified as high risk were invited to participate in a diabetes prevention program.

Results
A total of 180,000 SMSs were sent to approximately 6% of the adult population in Kuwait. Of these, 0.14% (260/180,000) of the individuals who received the SMS agreed to participate, of whom 58.8% (153/260) completed the screening. Surprisingly, additional surveys were completed by 367 individuals who were invited via circulated SMS messages forwarded by family members and friends. Altogether, 23.3% (121/520) qualified and agreed to participate in a diabetes prevention program. The majority of those who chose to participate in the prevention program were overweight, aged 45-65 years, and reported being less physically active than those who chose not to participate (χ22=42.1, P<.001).

Conclusions
Although health care screening via text messaging was found to have limited effectiveness by itself, it exhibited increased reach through shared second-party social media messaging. Despite the fact a subpopulation at possible risk of developing T2DM could be reached via text messaging, most responders were informed about the screening campaign by family and friends. Future research should be designed to tap into the benefits of social media use in health risk campaigns.
Patient and caregiver experiences at a specialized primary care center for autistic adults
Authors: Hand Brittany N , Coury Daniel L , Darragh Amy R , White Susan , Moffatt-Bruce Susan , Harris Lauren , Longo Anne , Gilmore Daniel , Garvin Jennifer H 
Published: September 2020

Background:
Little is known about the extent to which patient-centered medical homes meet the needs of autistic adults.
Materials & methods:
We conducted a cross-sectional survey of autistic adult patients (n = 47) and caregivers of autistic adult patients (n = 66) receiving care through one patient-centered medical home specifically designed to meet the needs of this population. We performed
post hoc
comparisons of our results to previously published data from a national sample of autistic adults.
Results:
Participants reported high levels of satisfaction with care, frequent preventive healthcare use and few unmet healthcare needs. Autistic adults in our sample reported significantly higher satisfaction and fewer unmet healthcare needs.
Conclusion:
A patient-centered medical home tailored to the needs of autistic adults is a promising approach to healthcare delivery for meeting this population’s needs.
Replication of randomized clinical trial results using real-world data: paving the way for effectiveness decisions
Authors: Sheffield Kristin M , Dreyer Nancy A , Murray James F , Faries Douglas E , Klopchin Megan N 
Published: September 2020

The FDA is preparing guidance about using real-world evidence (RWE) to support decisions about product effectiveness. Several ongoing efforts aim to replicate randomized clinical trial (RCT) results using RWE with the intent of identifying circumstances and methods that provide valid evidence of drug effects. Lack of agreement may not be due to faulty methods but rather to the challenges with emulating RCTs, differences in healthcare settings and patient populations, differences in effect measures and data analysis, bias, and/or the efficacy–effectiveness gap. In fact, for some decisions, RWE may lead to better understanding of how treatments work in usual care settings than a more constrained view from RCTs. Efforts to reconcile the role and opportunities for generating complementary evidence from RWE and RCTs will advance regulatory science.
Training of literacy-oriented teaching material development in MTs Al Ikhlas Soe, East Nusa Tenggara
Authors: Lestari Nurdiyah , Yusuf St. Muthmainnah , Ihwan I. , Mahfud M. , Ernawati E. , Jannah Nur 
Published: September 2020

In accordance with the paradigm of 21st century education, teachers are required to facilitate students with the learning process which addresses the improvement of students’ higher thinking skill. The community service which was conducted in MTs Al Ikhlas Soe, East Nusa Tenggara was aimed at: 1) culturing as well as developing students’ literacy in school; 2) improving students’ capacity in literacy; 3) managing students’ knowledge and higher thinking skill, as considerable as 4) elevating teachers’ professionalism so that learning process can be more effective and efficient. The methods used were lecture, discussion, brainstorming, simulation, and assignment. The materials delivered were about the arrangement and development of literacy-oriented teaching materials. The product produced from the training was implemented in learning process on VII graders. This was aimed to observe whether there was an improvement gained after the training given. The participants of this community service were 13 teachers and 34 students of MTs Al Ikhlas Soe. The results showed that teachers’ skill in arranging teaching materials has been improved. Furthermore, students’ understanding about the concept or their knowledge related to the materials has been upgraded after experiencing the implementation of literacy-oriented learning.
Effect of matrix rhythm therapy in Diabetic foot ulcer healing: A Case Report
Authors: Naik Varun , Khatri Chandra Bahadur , BR Ganesh 
Published: September 2020

Diabetic foot ulcer is one of the major complications following diabetes. In India, 15% of diabetic patient develop DFU once in their lifetime. Neuropathy associated with diabetes is a major factor in development of foot ulcer in such patients. Infection, peripheral arterial diseases, altered functions of white blood cells, stem cells and regenerating tissues and co-morbidities lead to delayed wound healing. Matrix rhythm therapy is a recent advancement in the field of Physiotherapy. It provides external oscillation that activates normal rhythm of cell that is between 8-12 Hz which improves cellular function within cell and extracellular matrix, enhancing tissue healing.
A 70 year female presented with infected diabetic foot ulcer on her right foot in out-patient department of KLE hospital. She had non-healing ulcer since one and half months and undergone conservative treatment of wound care along with strategies of diabetic foot care.
Clinical findings: Subject complained of Pain with score of 2 at rest and 6 while walking which was recorded on the basis of Visual Analogue Scale. Wound appeared ischemic and non-healing. On wound assessment, size of wound was 12mm in diameter and 6 mm depth. It was identified as Type D grade I on the basis of classification of wound provided by University of Texas Health Science center.
Intervention: Matrix rhythm therapy was applied on posterior aspect of leg region extending around wound area once a week for 5 weeks with treatment duration of one hour.
Result: Pain of the subject after 5 weeks of intervention was 0 at rest and 2 while walking on the basis of VAS. Size of wound decreased with dimension of 6mm in diameter and 2 mm depth and categorized as Type A grade 1.
Conclusion: Matrix rhythm therapy could be considered as adjunct in wound healing of diabetic foot ulcer.
Meningkatkan Keterampilan Berbicara Siswa Menggunakan Model Time Token Pembelajaran IPA Kelas V Sekolah Dasar
Authors: Siregar Rafika , Widowati Atri , Ali Muhammad 
Published: September 2020

This study aims to improve students' speaking skills in science learning through time token models in fifth grade students of SDN 43 / IV Jambi City.
This research is a classroom action research (CAR) consisting of two cycles, where the data taken is in the form of observation data through observation sheets of students' speaking skills and observation sheets of teacher activities. This research was conducted in 4 stages: planning, implementing, observing and reflecting. During the teaching and learning process learning activities apply the time token learning model.
The results of this study indicate the application of the time token model can improve students' speaking skills in natural science subjects. Based on the observation sheet the students' speaking skills showed an increase, with the results of the percentage of students speaking skills by 45% with a fairly good category in the first cycle and 68% with a good category in the second cycle.
Based on the findings of the research, it can be concluded that the speaking skills of science learning students in fifth grade students of SDN 43 / IV Jambi City can be improved after applying the time token model.
ANALISIS PERNIKAHAN USIA DINI DITINJAU DARI SUDUT PANDANG EKONOMI, SOSIAL DAN RELIGI : STUDI PADA KECAMATAN PURWODADI KABUPATEN GROBOGAN
Authors: Nurhayati Siti Fatimah , Kurniasasri Indah 
Published: September 2020

This study is entitled "Analysis of Early Age Marriage From an Economic, Social and Religious Perspective: Study in Purwodadi District Grobogan Regency" with the aim of analyzing patterns of early marriage and factors that encourage early marriage. The research data uses primary data with a population of 103 and taken as many as 50 samples. Methods of data collection through observation, interviews, questionnaires and documentation. The analytical tool in this study uses descriptive qualitative analysis. The results showed that there were 2 reasons for early marriage, namely because of their own desires and arranged marriages. There are 3 patterns of early marriage, namely dispensation from the religious court, increasing the age of the KTP and siri marriage, and there are several factors driving the occurrence of early marriage which include economic factors, social factors and religious factors.Penelitian ini bertujuan untuk menganalisis pola pernikahan usia dini dan faktor-faktor yang mendorong terjadinya pernikahan usia dini. Data penelitian menggunakan data primer dengan populasi sebanyak 103 dan diambil sampel sebanyak 50. Metode pengumpulan data melalui observasi, wawancara, angket dan dokumentasi. Alat analisis dalam penelitian ini menggunakan analisis deskriptif kualitatif. Hasil penelitian menunjukkan terdapat 2 alasan dalam melakukan pernikahan usia dini yaitu karena keinginan sendiri dan dijodohkan. Terdapat 3 pola pernikahan usia dini yaitu dispensasi dari pengadilan agama, menuakan umur di KTP dan nikah siri, serta ada beberapa faktor pendorong terjadinya pernikahan usia dini yaitu meliputi faktor ekonomi, faktor sosial dan faktor religi.
STRATEGI PEMBELAJARAN INOVATIF PENDIDIKAN AGAMA ISLAM DENGAN MEDIA POWERPOINT DALAM MENINGKATKAN MUTU PENDIDIKAN DI SDIT MUHAMMADIYAH SINAR FAJAR CAWAS DAN SD MUHAMMADIYAH PK BAYAT
Authors: Trihariyanto Sigit , Supriyanto Eko , Muthoifin Muthoifin , 'Uyun Zahrotul 
Published: September 2020

Penelitian ini dilaksanakan dengan tujuan untuk mengungkap, menganalisis dan menjelaskan strategi pembelajaran dan pemanfaatan media powerpoint yang diterapkan guru pendidikan agama Islam dalam menyampaikan materi pembelajaran di Sekolah Dasar Islam Terpadu Muhammadiyah Sinar Fajar Cawas dan Sekolah Dasar Muhammadiyah Program Khusus Bayat. Jenis Penelitian ini adalah penelitian lapangan (field research) dengan menggunakan pendekatan deskriptif kualitatif. Adapun sumber data dan instrumen yang digunakan dalam penelitian ini adalah observasi, wawancara dan studi dokumentasi. Berdasarkan penelitian yang telah dilakukan diperoleh hasil bahwa Sekolah Dasar Islam Terpadu Muhammadiyah Sinar Fajar Cawas dan Sekolah Dasar Muhammadiyah Program Khusus Bayat telah menerapkan kurikulum 2013. Sehingga guru memiliki peranan yang sangat penting dalam pendidikan. Di antara peranan guru yang ditunjukkan di kedua sekolah tersebut adalah guru sebagai perencana, pengelola, pelaksana dan evaluator. Selain itu, guru juga berperan sebagai pentransfer ilmu, pembina akhlak mulia, mediator dan fasilitator. Dalam penerapan strategi pembelajaran pendidikan agama Islam dengan media powerpoint di kedua sekolah tersebut mampu memberikan motivasi dan meningkatkan semangat belajar peserta didik serta prestasi belajarnya. Dalam pemanfaatan strategi tersebut mampu menjadikan proses pembelajaran semakin lebih menarik, efektif, efisien dan dapat membantu dalam pengkondisian peserta didik dalam proses pembelajaran serta menambah rasa percaya diri bagi guru pendidikan agama Islam. Adapun untuk materi yang disampaikan dengan memanfaatkan strategi ini, maka lebih mudah dipahami dan penyimpanan filenya lebih praktis. Faktor pendukung dalam penerapan strategi pembelajaran pendidikan agama Islam dengan media powerpoint di Sekolah Dasar Islam Terpadu Muhammadiyah Sinar Fajar Cawas dan Sekolah Dasar Muhammadiyah Program Khusus Bayat adalah kemampuan guru dalam mengoperasikan komputer, ketersediaan sumber media, sarana dan prasarana berbasis komputer di sekolah, dukungan dari kepala sekolah, dan kondisi lingkungan sekolah yang kondusif serta budaya saling tolong menolong yang terbangun cukup kuat. Adapun untuk faktor penghambatnya adalah kurang terbiasanya guru dalam menggunakan media powerpoint dalam proses pembelajaran, waktu persiapan yang masih terbatas, dan jumlah sarana dan prasarana berbasis komputer yang masih terbatas juga.