bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pattern theory of self and situating moral aspects: the need to include authenticity, autonomy and responsibility in understanding the effects of deep brain stimulation
Authors: Zawadzki Przemysław 
Published: November 2020

AbstractThe aims of this paper are to: (1) identify the best framework for comprehending multidimensional impact of deep brain stimulation (DBS) on the self; (2) identify weaknesses of this framework; (3) propose refinements to it; (4) in pursuing (3), show why and how this framework should be extended with additional moral aspects and demonstrate their interrelations; (5) define how moral aspects relate to the framework; (6) show the potential consequences of including moral aspects on evaluating DBS’s impact on patients’ selves. Regarding (1), I argue that the pattern theory of self (PTS) can be regarded as such a framework. In realizing (2) and (3), I indicate that most relevant issues concerning PTS that require resolutions are ontological issues, including the persistence question, the “specificity problem”, and finding lacking relevant aspects of the self. In realizing (4), I identify aspects of the self not included in PTS which are desperately needed to investigate the full range of potentially relevant DBS-induced changes—authenticity, autonomy, and responsibility, and conclude that how we define authenticity will have implications for our concept of autonomy, which in turn will determine how we think about responsibility. Concerning (5), I discuss a complex relation between moral aspects and PTS—on one hand, they serve as the lens through which a particular self-pattern can be evaluated; on the other, they are, themselves, products of dynamical interactions of various self-aspects. Finally, I discuss (6), demonstrating novel way of understanding the effects of DBS on patients’ selves.
Science and Religious Education Teachers’ Views of Argumentation and Its Teaching
Authors: Erduran Sibel , Guilfoyle Liam , Park Wonyong 
Published: November 2020

AbstractArgumentation, the justification of claims with reasons and/or evidence, has emerged as a significant educational goal in science education in recent years. It has also been noted as an important pedagogical approach in numerous school subjects. Yet, there is limited understanding of how teachers’ views of argumentation and its teaching compare in different school subjects. In order to ensure coherence in the implementation of the school curriculum, it is important to understand such views particularly in the context of subjects that are often positioned to be in conflict with each other, for example in the context of science versus religious education. In this paper, we present an empirical study on how science and religious education teachers view argumentation and its teaching. The data are drawn from a survey of secondary school teachers of 11–16-year-old students in England. Twenty-nine teachers were presented with an online survey in order to collect data on various aspects of their views including pedagogical strategies that support argumentation. Qualitative and quantitative results suggest that teachers of both subjects consider argumentation to be a significant aspect of their subject although particular nuances exist in how the teachers interpret argumentation. Furthermore, the data suggest that there are statistically significant differences in terms of the perceived frequency of pedagogical strategies used to support argumentation in lessons.
Fluid Leakage in Metallic Seals
Authors: Fischer F. J. , Schmitz K. , Tiwari A. , Persson B. N. J. 
Published: November 2020

AbstractMetallic seals are crucial machine elements in many important applications, e.g., in ultrahigh vacuum systems. Due to the high elastic modulus of metals, and the surface roughness which exists on all solid surfaces, if no plastic deformation would occur one expects in most cases large fluid flow channels between the contacting metallic bodies, and large fluid leakage. However, in most applications plastic deformation occurs, at least at the asperity level, which allows the surfaces to approach each other to such an extent that fluid leakage often can be neglected. In this study, we present an experimental set-up for studying the fluid leakage in metallic seals. We study the water leakage between a steel sphere and a steel body (seat) with a conical surface. The experimental results are found to be in good quantitative agreement with a (fitting-parameter-free) theoretical model. The theory predicts that the plastic deformations reduce the leak-rate by a factor$$\approx 8$$≈8.
Are we ignoring a black elephant in the Anthropocene? Climate change and global pandemic as the crisis in health and equality
Authors: Asayama Shinichiro , Emori Seita , Sugiyama Masahiro , Kasuga Fumiko , Watanabe Chiho 
Published: November 2020

AbstractClimate change and coronavirus pandemic are the twin crises in the Anthropocene, the era in which unsustainable growth of human activities has led to a significant change in the global environment. The two crises have also exposed a chronic social illness of our time—a deep, widespread inequality in society. Whilst the circumstances are unfortunate, the pandemic can provide an opportunity for sustainability scientists to focus more on human society and its inequalities, rather than a sole focus on the natural environment. It opens the way for a new normative commitment of science in a time of crises. We suggest three agendas for future climate and sustainability research after the pandemic: (1) focus on health and well-being, (2) moral engagement through empathy, and (3) science of loss for managing grief.
Bariatric Surgery Is Protective Against Renal Function Decline in Severely Obese Patients in the Long-Term
Authors: Lautenbach Anne , Wienecke Jan-Wilhelm , Stoll Fabian , Riedel Nina , Mann Oliver , Huber Tobias B. , Busch Philipp , Aberle Jens 
Published: November 2020

Abstract
Purpose
This study aims to assess the long-term renal effects of bariatric surgery (BS) in severely obese patients over a follow-up period of up to 11 years.

Materials and Methods
In a retrospective cohort study including 102 patients, patients were stratified by eGFR at baseline and divided into three groups: (1) reduced, (2) normal, and (3) increased filtration rate. Adjustments for age- and sex-related decline in eGFR were performed. We used uni- and multivariate regression analysis to identify variables that were thought to determine change in eGFR.

Results
Over a median follow-up of 8.5 years (interquartile range 2.7), eGFR declined from 96.1 ± 20.7 to 84.9 ± 21.0 ml/min (p < 0.001). Among patients with (1), eGFR remained stable (69.1 ± 19.3 ml/min). Among patients with (2), eGFR declined from 99.7 ± 13.3 ml/min to 88.7 ± 19.4 ml/min (p < 0.001). Among patients with (3), eGFR decreased to normal levels (94.2 ± 17.7 ml/min, p < 0.001). Age- and sex-adjusted eGFR increased (6.4 ± 14.4 ml/min; p < 0.05) among patients with reduced filtration rate. Among patients with normal filtration rate, adjusted eGFR remained stable during follow-up (−1.3 ± 15.2 ml/min; n.s.). Among patients with increased filtration rate, adjusted eGFR decreased and remained within the normal range (−13.2 ± 12.2 ml/min; p < 0.001). Change in eGFR showed a negative correlation with eGFR at baseline (B = −0.31; p < 0.001), change in LDL-cholesterol (B = -0.09; p < 0.05), and a negative correlation with treatment requiring hypertension (B = -9.36; p = 0.001).

Conclusion
BS is protective against renal function decline in severely obese patients in the long term.
Interactive freehand sketching as the means for online communication of design intent in conceptual design conducted by Brainwriting
Authors: Rizzuti Sergio , De Napoli Luigi 
Published: November 2020

AbstractSketching is becoming an irrelevant activity of engineering studies. The availability of many software that aids designers in all phases of design, not only analytic but synthetic, push technicians, designers to use such tools, giving up the employment of a simple pencil and eraser on a sheet of paper. The productivity of software tools is obliged to speed and manage the whole design process; even freehand sketching remains the fundamental means to communicate the first ideas immediately. During Brainwriting sessions, the ability to explain by sketches first elaborations of a possible solution, that must be understood by co-designers, is the first step that allows more fruitful discussion and immediate adjustment towards a quick embodiment of valid proposals. The paper describes how such techniques has been introduced in the mechanical engineering curriculum. The case of study reports the experience of the Brainwriting online, which has been tested during lockdown due to the pandemic disease of COVID-19. Further in the paper it is suggested a new interpretation of the de Saussure general linguistic studies, in term of a communication that is associated to a drawing.
1H, 13C, and 15N backbone chemical shift assignments of coronavirus-2 non-structural protein Nsp10
Authors: Kubatova N. , Qureshi N. S. , Altincekic N. , Abele R. , Bains J. K. , Ceylan B. , Ferner J. , Fuks C. , Hargittay B. , Hutchison M. T. , de Jesus V. , Kutz F. , Wirtz Martin M. A. , Meiser N. , Linhard V. , Pyper D. J. , Trucks S. , Fürtig B. , Hengesbach M. , Löhr F. , Richter C. , Saxena K. , Schlundt A. , Schwalbe H. , Sreeramulu S. , Wacker A. , Weigand J. E. , Wirmer-Bartoschek J. , Wöhnert J. 
Published: November 2020

AbstractThe international Covid19-NMR consortium aims at the comprehensive spectroscopic characterization of SARS-CoV-2 RNA elements and proteins and will provide NMR chemical shift assignments of the molecular components of this virus. The SARS-CoV-2 genome encodes approximately 30 different proteins. Four of these proteins are involved in forming the viral envelope or in the packaging of the RNA genome and are therefore called structural proteins. The other proteins fulfill a variety of functions during the viral life cycle and comprise the so-called non-structural proteins (nsps). Here, we report the near-complete NMR resonance assignment for the backbone chemical shifts of the non-structural protein 10 (nsp10). Nsp10 is part of the viral replication-transcription complex (RTC). It aids in synthesizing and modifying the genomic and subgenomic RNAs. Via its interaction with nsp14, it ensures transcriptional fidelity of the RNA-dependent RNA polymerase, and through its stimulation of the methyltransferase activity of nsp16, it aids in synthesizing the RNA cap structures which protect the viral RNAs from being recognized by the innate immune system. Both of these functions can be potentially targeted by drugs. Our data will aid in performing additional NMR-based characterizations, and provide a basis for the identification of possible small molecule ligands interfering with nsp10 exerting its essential role in viral replication.
A groundwater potential zone mapping approach for semi-arid environments using remote sensing (RS), geographic information system (GIS), and analytical hierarchical process (AHP) techniques: a case study of Buffalo catchment, Eastern Cape, South Africa
Authors: Owolabi Solomon Temidayo , Madi Kakaba , Kalumba Ahmed Mulakazi , Orimoloye Israel Ropo 
Published: November 2020

AbstractTheme unsuitability is noted to have inhibited the accuracy of groundwater potential zones (GWPZs) mapping approach, especially in a semi-arid environment where surface water supply is inadequate. This work, therefore presents a geoscience approach for mapping high-precision GWPZs peculiar to the semi-arid area, using Buffalo catchment, Eastern Cape, South Africa, as a case study. Maps of surficial-lithology, lineament-density, drainage-density, rainfall-distribution, normalized-difference-vegetation-index, topographic-wetness-index, land use/land cover, and land-surface-temperature were produced. These were overlaid based on analytical hierarchical process weightage prioritization at a constituency ratio of 0.087. The model categorizes GWPZs into the good (187 km2), moderate (338 km2), fair (406 km2), poor (185 km2), and very poor (121 km2) zones. The model validation using borehole yield through on the coefficient of determination (R2 = 0.901) and correlation (R = 0.949) indicates a significant replication of ground situation (p value < 0.001). The analysis corroboration shows that the groundwater is mainly hosted by a fractured aquifer where the GWPZs is either good (9.3 l/s) or moderate (5.5 l/s). The overall result indicates that the model approach is reliable and can be adopted for a reliable characterization of GWPZs in any semi-arid/arid environment.
Evaluation of the drainage system of Zagros Basin (Greater Zab River, northern Iraq) and insights into tectonic geomorphology
Authors: Elias Ziyad , Sissakian Varoujan K. , Al-Ansari Nadhir 
Published: November 2020

AbstractGeomorphological evaluation was carried out for three drainage basins named Hareer, Dwaine, and Hijran, which are tributaries of the Greater Zab River in the northern part of Erbil Governorate, the Iraqi Kurdistan Region, north Iraq. The exposed rocks in the three basins are mainly clastic rocks (sandstone, claystone, and conglomerate, with subordinate gypsum and limestone beds). However, in the uppermost parts of the basins, thick and massive carbonate rocks are exposed. Tectonically, the three basins are located in the Low Folded and High Folded Zones, which belong to the Zagros Fold–Thrust Belt. The main aim of the current study is to deduce the tectonic activity of the area occupied by the studied three basins. We have used and interpreted Radar Topography Mission (SRTM) data to perform the geomorphological evaluation. Different geomorphological indices and forms were used to deduce the tectonic activity of the area occupied by the three basins. Accordingly, seven orders of streams were identified in the three basins. The number of the streams with low order (i.e., 1) joining with higher order (i.e., 6 and 7) is considerably higher in the three basins. The Hat values of the three basins are 12,971, 10,479, and 7014 in Hareer, Dwaine, and Hijran basins, respectively. The values of hierarchical anomaly index (Δa) of the three basins are 1.87, 1.35, and 2.37 in Hareer, Hijran, and Dwaine basins, respectively. It was observed that the shape of Hareer and Shakrook anticlines has a significant impact on the main trunk of the channel. Therefore, when an anticline and syncline are close to each other (due to thrust faulting), then the hierarchical anomaly increases because the river trunk receives a lot of first-order streams, e.g., in Dwaine and Hijran basins. The lateral growth in the eastern part of Safin anticline had caused increasing of the Δa. The increased hierarchical anomaly index is attributed to the existence of faults and lineaments, which represent weakness zones. The hypsometric curves of the three basins have a typical shape of old stage with rejuvenation in their central and terminal portions which is changed into mature stage, most probably due to the local uplift which is caused by normal, thrust, and strike–slip (oblique) faults which exist in the study area and the near surroundings. The Bs and Hat values in Hareer, Dwaine, and Hijran basins indicate that the basins exhibit low, medium, and high tectonic activity, respectively.
Mixture Kernel Density Estimation and Remedied Correlation Matrix on the EEG-Based Copula Model for the Assessment of Visual Discomfort
Authors: Zheng Yawen , Zhao Xiaojie , Yao Li 
Published: November 2020

AbstractSince electroencephalogram (EEG) signals can directly provide information on changes in brain activity due to behaviour changes, how to assess visual discomfort through EEG signals attracts researchers’ attention. However, previous assessments based on time-domain EEG features lack sufficient consideration of the dependence among EEG signals, which may affect the discrimination to visual discomfort. Although the copula model can explore the dependence among variables, the EEG-based copula models still have the following deficiencies: (1) the methods ignoring the fine-grained information hidden in EEG signals could make the estimated marginal density function improper, and (2) the approaches neglecting the pseudo-correlation among data may inappropriately estimate the correlation matrix parameter of the copula density function. The mixture kernel density estimation (MKDE) and remedied correlation matrix (RCM) on the EEG-based copula model are proposed to mitigate the mentioned shortcomings. The simulation experiments show that MKDE can not only better estimate the marginal density function but also explore fine-grained information. The RCM can be closer to the real correlation matrix parameter. With the favourable quality of the proposed EEG-based model, it is used to extract time-domain EEG features to assess visual discomfort further. To our best knowledge, the extracted features present better discrimination to visual discomfort compared with the features extracted by the state-of-the-art method.
Anticancer Properties of Lobetyolin, an Essential Component of Radix Codonopsis (Dangshen)
Authors: Bailly Christian 
Published: November 2020

AbstractLobetyolin (LBT) is a polyacetylene glycoside found in diverse medicinal plants but mainly isolated from the roots of Codonopsis pilosula, known as Radix Codonopsis or Dangshen. Twelve traditional Chinese medicinal preparations containing Radix Codonopsis were identified; they are generally used to tonify spleen and lung Qi and occasionally to treat cancer. Here we have reviewed the anticancer properties of Codonopsis extracts, LBT and structural analogs. Lobetyolin and lobetyolinin are the mono- and bis-glucosylated forms of the polyacetylenic compound lobetyol. Lobetyol and LBT have shown activities against several types of cancer (notably gastric cancer) and we examined the molecular basis of their activity. A down-regulation of glutamine metabolism by LBT has been evidenced, contributing to drug-induced apoptosis and tumor growth inhibition. LBT markedly reduces both mRNA and protein expression of the amino acid transporter Alanine-Serine-Cysteine Transporter 2 (ASCT2). Other potential targets are proposed here, based on the structural analogy with other anticancer compounds. LBT and related polyacetylene glycosides should be further considered as potential anticancer agents, but more work is needed to evaluate their efficacy, toxicity, and risk–benefit ratio.
Abdominal Wall Transplantation: Indications and Outcomes
Authors: Honeyman Calum , Dolan Roisin , Stark Helen , Fries Charles Anton , Reddy Srikanth , Allan Philip , Vrakas Giorgios , Vaidya Anil , Dijkstra Gerard , Hofker Sijbrand , Tempelman Tallechien , Werker Paul , Erdmann Detlev , Ravindra Kadiyala , Sudan Debra , Friend Peter , Giele Henk 
Published: November 2020

Abstract
Purpose of Review
This article aims to review published outcomes associated with full-thickness vascularized abdominal wall transplantation, with particular emphasis on advances in the field in the last 3 years.

Recent Findings
Forty-six full-thickness vascularized abdominal wall transplants have been performed in 44 patients worldwide. Approximately 35% of abdominal wall transplant recipients will experience at least one episode of acute rejection in the first year after transplant, compared with rejection rates of 87.8% and 72.7% for hand and face transplant respectively. Recent evidence suggests that combining a skin containing abdominal wall transplant with an intestinal transplant does not appear to increase sensitization or de novo donor-specific antibody formation.

Summary
Published data suggests that abdominal wall transplantation is an effective safe solution to achieve primary closure of the abdomen after intestinal or multivisceral transplant. However, better data is needed to confirm observations made and to determine long-term outcomes, requiring standardized data collection and reporting and collaboration between the small number of active transplant centres around the world.
Clinical Longevity of Zirconia Implants with the Focus on Biomechanical and Biological Outcome
Authors: Kohal Ralf-Joachim , Dennison David K. 
Published: November 2020

Abstract
Purpose of Review
The goal of the present review is to update the reader on the scientific background of zirconia ceramic implants. Clinical investigations using zirconia ceramic implants over the last couple of years have brought up some new developments and questions. Can we be confident in placing zirconia ceramic implants given the recently published data? Is there a difference in the application of one- and two-piece implants?

Recent Findings
Systematic reviews on preclinical investigations of zirconia implants revealed that one-piece zirconia implants (> 4 mm) are sufficiently stable for clinical use. The same is true for some clinically available two-piece implant systems. Osseointegration and soft tissue integration are, according to the reviews, similar between titanium and zirconia implants with similar surface topographies. Regarding the clinical outcome, a meta-review exists evaluating systematic reviews. The findings of the systematic reviews and the meta-review are that there are good short-term clinical results for one-piece zirconia implants. However, the data for two-piece implants is not robust.

Summary
In certain applications (single tooth restorations and small bridges), the results of zirconia implants are comparable with titanium implants in short-term studies. Some mid-term investigations support the short-term results. However, according to the current scientific data available, zirconia implants cannot yet be considered an alternative to titanium implants because there are many areas where there is a lack of clinical studies on zirconia implants. Currently, they are an addendum to the titanium implant armamentarium for situations where they are useful (patient request, known hypersensitivity to titanium, or questions of esthetics when titanium might appear inappropriate for a certain situation/condition), but long-term studies are needed. Without a doubt, there is a need for two-piece zirconia implants, but limited research exists to support their clinical use at the moment.
Predictors for functional decline after an injurious fall: a population-based cohort study
Authors: Ek Stina , Rizzuto Debora , Xu Weili , Calderón-Larrañaga Amaia , Welmer Anna-Karin 
Published: November 2020

Abstract
Background
The functional consequences of injurious falls are well known. However, studies of the factors that can modify trajectories of disability after an injury from a fall are scarce.

Aims
We aimed to investigate whether sociodemographic and health-related factors may impact this association.

Methods
The study population consisted of 1426 community-dwelling older adults (≥ 60 years) from the SNAC-K cohort study in Stockholm, Sweden. Functional status over 12 years of follow-up was assessed using the number of limitations in basic and instrumental activities of daily living. Sex, cohabitation status, physical activity, and self-rated health were assessed at baseline. Injurious falls were defined as falls requiring healthcare and were assessed over 3 years starting at baseline. Data were analyzed using linear-mixed effects models.

Results
The fastest increase in the number of disabilities was observed in those who had endured an injurious fall and were living alone (β coefficient = 0.408; p < 0.001), been physically inactive (β coefficient = 0.587; p < 0.001), and had poor self-rated health (β coefficient = 0.514; p < 0.001). The negative impact of these factors was more pronounced among fallers compared to non-fallers.

Discussion
Living alone, being physically inactive, and having poor self-rated health magnifies the negative effect of an injurious fall on functional status. Among individuals who endure an injurious fall, the heterogeneity in long-term functional status is substantial, depending on the individuals’ characteristics and behaviors.

Conclusions
These findings emphasize the need for a person-centered approach in care provision and can guide secondary prevention within health care.