bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of AI on Talent Acquisition: Opportunities and Challenges in Modern HR Practices
Authors: Faqih Mustofa , Sukistini Anastasia Sri , Asrianto Asrianto , Siri Abu , Nggandung Yeheskial 
Published: December 2024

The development of artificial intelligence (AI) has changed various aspects of human resource management, including the talent acquisition process to become more efficient and structured. However, the application of AI in recruitment also presents challenges, especially related to the issue of algorithmic and ethical bias, which can affect fairness in the candidate selection process. This study aims to evaluate the impact of AI on talent acquisition, including the potential opportunities and challenges that organizations face in their implementation. This study uses a qualitative method with a literature review approach, which aims to identify, analyze, and synthesize previous studies on the impact of artificial intelligence (AI) in talent acquisition, especially on opportunities and challenges in modern HR practices. The results show that AI has great potential to change the way organizations acquire talent, but its application must be done with caution. By understanding the advantages and disadvantages of AI in this context, organizations can leverage technology to achieve efficiency without sacrificing existing ethical values and social decency.
Optimization of Evaluation Criteria for Energy Research Proposals using the Patton-Sawicki Framework: A Case Study in The Research Organization for Energy and Manufacture
Authors: Setyowati Lia Agustina , Ningrum Sinta , Nurasa Heru , Wardani Lindawati 
Published: December 2024

The global energy crisis has affected energy markets and policies around the world. In addition, the issue of global warming requires the world to switch to clean energy sources. The Indonesian government has committed to switching from fossil energy subsidies to renewable energy to achieve Net Zero Emissions (NZE) by 2060 or sooner. The National Research and Innovation Agency (BRIN) established the Energy and Manufacturing Research Organization (OREM) to support the NZE program. One of OREM's initiatives is the Call For Joint Collaboration (CFJC) which provides an opportunity for researchers to propose research proposals in various energy fields. However, the assessment of the CFJC proposal has not used scientific methods or criteria so that the results of the proposal evaluation are not optimal yet. Therefore, this study proposes optimization of evaluation criteria using the Patton-Sawicki Framework to determine the qualified proposal to be accepted. The research uses a qualitative approach method using CFJC proposal data on OREM in 2023. The results show that the proposed method is able to improve the quality of the proposal evaluation process by only accepting proposals that meet the requirements to support the development of NRE sector in Indonesia.
NUTROMEDICINA E NUTROLOGIA MOLECULAR: ASPECTOS METABÓLICOS DOS NUTRIENTES NA SAÚDE HUMANA GERAL E NA PERFORMANCE FÍSICA.
Authors: Rosa Edson Carlos Zaher 
Published: December 2024

A Nutromedicina Clínica e a Nutrologia Molecular representam áreas em rápida evolução, focadas na interação dos nutrientes com processos bioquímicos, genômicos e metabólicos que regulam a saúde humana.

Este artigo revisa detalhadamente o papel dos macronutrientes, os micronutrientes e compostos bioativos na modulação de vias metabólicas, inflamatórias e epigenéticas. Além disso, explora a aplicação de áreas conexas como a Nutrigenômica, a Farmacologia Nutricional e a Nutrologia do Esporte, com a suplementação na prática esportiva, visando o aumento de desempenho físico de adeptos e atletas profissionais. Assim sendo, combinando ciência básica e prática clínica, busca-se oferecer uma visão abrangente da importância dos nutrientes na manutenção da homeostase e na promoção da longevidade e performance física, com aplicabilidade em áreas como Medicina Interna (Clínica Médica), Medicina do Esporte, Geriatria, Endocrinologia, Gastroenterologia, Psiquiatria, Cirurgia Geral, Cirurgia de Cabeça e Pescoço, Cirurgia Maxilo Facial, dentre outras.
為何你買不起房子？
Authors: Ryan-Collins Josh 
Published: December 2024

住屋是現代人之必須，然而樓價節節上升，千禧世代不靠父幹，難以搭上樓市順風車。

但是，樓價為何一直高企不下？

有人說是「供應不足」，有人說「移民過多」，本書作者、頂尖經濟學家約書．萊恩—柯林斯卻大膽從「土地」與「金錢」的經濟概念出發，提出「金融—房屋反饋循環」理論：銀行信貸無限擴張，金錢流進不可再生、限量供應的土地，推高樓價，更促使房屋從「民生必需品」變成投機的籌碼；金融管制進一步放寬，銀行將按揭貸款組裝成證券公開發售，將全球捆綁進此一循環之中。

如此操作，使經濟體債台高築，脆弱不穩，2008年次按危機即可視為金融—房屋反饋循環演算的Bad End。到底是怎樣的歷史社會環境，令國家政府與普羅大眾一同甘之如飴地參與這場「音樂椅」遊戲？要避免下一波金融危機重臨，我們需要怎樣的改革？

這本輕巧的小書，讓你一次讀懂土地的功能、自置物業的歷史、金融部門與政府如何合作解決公共債務的同時助長按揭貸款無限增加。想知道自己為甚麼買不起房子，收入總追不上樓價？除了「後生吃不了苦」這種偽命題外，你需要本書提供的更準確深入的解說。
Personalized Medicine in Oncology Drug Development
Authors: Dracopoli Nicholas C. , Grewal Iqbal , Takimoto Chris H. , Lebowitz Peter F. 
Published: December 2019

OverviewThe concept of personalized medicine in oncology drug development is no longer an aspiration; it is now, in large measure, the accepted paradigm of how oncology drugs should be developed. In modern oncology drug development, determining which molecularly characterized tumors will benefit the most from a drug is a critical part of the development plan. In addition, another important personalized medicine approach is emerging whereby a therapeutic is specific to an individual patient. Examples of this individualized therapeutic approach include engineering of autologous immune cells with reinfusion into the patient or cancer vaccines that are specific to an individual tumor.A growing number of successful examples have demonstrated that the personalized medicine approach via biomarker selection can provide more benefit to patients and more rapid approval of drugs. The benefits of a personalized medicine strategy in oncology drug development are multiple and include an increased probability of overall success, smaller phase 3 registration trials, and the potential for enhanced clinical benefits for patients. In a recent review, Falconi and colleagues examined the outcome of 676 phase 1, 2, and 3 clinical trials of novel therapeutics for non‐small‐cell lung cancer (NSCLC) conducted from 1998 to 2012.1Overall, the cumulative success rate, as defined by the advancement to the next stage of clinical testing or to approval, was only 11%. However, when a biomarker was utilized for patient selection, the cumulative success rate increased by nearly sixfold to 62%. Thus, there is strong objective evidence for predictive biomarkers to enhance the probability of success in drug development. Using specific genetic and/or protein markers, a number of important drugs have been developed and approved in specific populations. This approach represents a paradigm shift that has proved so powerful that it is now a standard.The European Society for Medical Oncology has published a Glossary on Precision Medicine2with important definitions. Additionally, a workshop regarding “The drug development paradigm in oncology” was held in Washington DC in December 2016 with the participation of multiple stakeholders (researchers, patient advocates and representatives from industry, academia, and government), and multiple strategies to improve drug development in oncology were discussed.3
Neoplasms of the Cervix
Authors: Jhingran Anuja , Rodriguez Ana M. 
Published: December 2019

OverviewCervical cancer is the fourth most common cancer among women worldwide and the fourth leading cause of cancer deaths in females, with an estimated 529,800 new cases and 275,100 deaths in the year 2008. The incidence is declining in the United States with 12,900 new cases and 4100 deaths in 2015. Squamous cell carcinoma is the most common histology, with the human papilloma virus (HPV) being the most common etiology. Cervical cancer can be easily prevented with pap smears, HPV testing, and hopefully the HPV vaccine. Early‐stage cervix cancer can be treated with surgery including now fertility sparing surgery, and there are high cure rates. Local advance cervical cancer is treated with a combination of chemotherapy and radiation therapy with high survival rates, but there is room for improvements with advancing stage. Systemic chemotherapy can be used for treatment of both recurrent and metastatic disease, but careful attention should be paid to balancing benefit and toxicity. The key to success will be the transportation of success seen in the developing countries to success in the areas of the world where advanced‐stage invasive cervical cancer is most common.
Leukocyte telomere length in patients with myotonic dystrophy type I: a pilot study
Authors: Wang Youjin , Best Ana , Fernández‐Torrón Roberto , Alsaggaf Rotana , Garcia‐Puga Mikel , Dagnall Casey L. , Hicks Belynda , Thompson Mone’t , Matheu Fernandez Ander , Zulaica Ijurco Miren , Greene Mark H. , Lopez de Munain Adolfo , Gadalla Shahinaz M. 
Published: December 2019

AbstractMyotonic dystrophy type I (DM1) is an autosomal dominant disease of which clinical manifestations resemble premature aging. We evaluated the contribution of telomere length in pathogenesis in 361 DM1 patients (12 with serial measurements) and 223 unaffected relative controls using qPCR assay. While no differences in baseline leukocyte relative telomere length (RTL) was noted, the data suggested an accelerated RTL attrition in DM1 (discovery cohort: T/S change/year = −0.013 in DM1 vs. −0.005 in controls, P = 0.04); similar trend was noted in validation cohort. Further investigations are needed to examine the role of TL in the pathophysiology of DM1.
Stretching Induces Overexpression of RhoA and Rac1 GTPases in Breast Cancer Cells
Authors: Yadav Sharda , Barton Matthew , Nguyen Nam‐Trung 
Published: December 2019

AbstractRho GTPases are well known for regulating cell morphology and intracellular interactions. They can either be oncogenic or tumor suppressors. However, these proteins are associated with the acquirement of malignant features by cancer cells. It has been reported that the overexpression of protein markers of Rho family members such as RhoA and Rac1 is linked with carcinogenesis and the progression of a variety of human tumors. In this paper, the expression of RhoA and Rac1 activity in various types of breast cancers cell lines is evaluated. These cells are preconditioned by mechanically stretching them to simulate the extracellular physical forces placed upon on cancer cells. It is observed that stretching the cancer cells induces significantly higher expression of RhoA and Rac1 markers when compared to non‐stretched cells and stretched control cells in vitro. This stretching strategy helps to detect and quantify the signal when it is too weak to be detected. Furthermore, stretching enhances the assay by leading to overexpression of markers and makes the assay more sensitive. It is hypothesized that this inexpensive and relatively sensitive assay can potentially aid in the development of a diagnostic tool for cancer screening.
The contribution of hybridization to range‐wide population genetic structure in a Pacific coastal dune plant
Authors: López‐Villalobos Adriana , Eckert Christopher G. 
Published: December 2019

PremiseInterspecific hybridization can cause genetic structure across species ranges if the mating system and degree of sympatry/parapatry with close relatives varies geographically. The coastal dune endemicCamissoniopsis cheiranthifolia(Onagraceae) exhibits genetic subdivisions across its range, some of which are associated with shifts in mating system from outcrossing to selfing, while others are not. For instance, strong differentiation between large‐flowered, self‐incompatible (LF‐SI) and large‐flowered, self‐compatible (LF‐SC) populations occurs without much reduction in outcrossing or obvious barriers to gene flow. We hypothesized thatLF‐SIdiverged fromLF‐SCvia hybridization with the predominantly inlandSIsister speciesC. bistorta.MethodsWe analyzed spatial proximity using 1460 herbarium records and genetic variation at 12 microsatellites assayed for 805 and 404 individuals from 32C. cheiranthifoliaand 18C. bistortapopulations, respectively. We also assayed nine chloroplast microsatellites for 124 and 111 individuals from 27 and 19 populations, respectively.ResultsCloser parapatry was associated with unexpectedly high genetic continuity betweenLF‐SIC. cheiranthifoliaandC. bistorta.LF‐SIgenotypes clustered withC. bistortaexclusive of otherC. cheiranthifoliagenotypes. Similarly, pairwiseFSTamongSIC. cheiranthifoliaandC. bistorta, adjusted for geographic proximity, was not higher between heterospecific than conspecific populations.ConclusionsThe lack of genetic differentiation betweenLF‐SIC. cheiranthifoliaandC. bistortapopulations, even those located away from the zone of parapatry, suggests that, instead of hybridizing withC. bistorta,LF‐SIC. cheiranthifoliais rather an ecotype ofC. bistortathat has adapted to coastal dune habitat independent of other lineages inC. cheiranthifoliaproper.
Ein Fall für die Bindungs‐Netzwerk‐Analyse bei der Synthese verbrückter polycyclischer komplexer Moleküle: Hetidin‐ und Hetisin‐Diterpen‐Alkaloide
Authors: Doering Nicolle A. , Sarpong Richmond , Hoffmann Reinhard W. 
Published: December 2019

AbstractEine zentrale Herausforderung bei der Synthese von Diterpen‐Alkaloiden besteht darin, Strategien zu identifizieren, mit denen sich die mehrfach verbrückten polycyclischen Gerüste schnell aufbauen lassen. Bisherige Ansätze für den Aufbau dieser strukturell komplexen Sekundär‐Metaboliten werden im Rahmen einer “Bindungs‐Netzwerk‐Analyse” von Molekülgerüsten diskutiert, die ursprünglich von Corey vor etwa vierzig Jahren entwickelt wurde. Die Retrosynthesepläne, die sich aus einer topologischen Analyse der hochverbrückten Gerüste der Diterpen‐Alkaloide ergeben, werden im Kontext von acht neueren Synthesen von Hetidin‐ und Hetisin‐Naturstoffen und deren Derivaten diskutiert. Dieser Kurzaufsatz zeigt, inwieweit Netzwerk‐Analysen der hier beschriebenen Art für die Erarbeitung von Syntheseplänen ausreichen und wo sie mit Funktionsgruppen‐orientierten Syntheseüberlegungen zusammengeführt werden mussten.
Selective and Wash‐Resistant Fluorescent Dihydrocodeinone Derivatives Allow Single‐Molecule Imaging of μ‐Opioid Receptor Dimerization
Authors: Gentzsch Christian , Seier Kerstin , Drakopoulos Antonios , Jobin Marie‐Lise , Lanoiselée Yann , Koszegi Zsombor , Maurel Damien , Sounier Rémy , Hübner Harald , Gmeiner Peter , Granier Sébastien , Calebiro Davide , Decker Michael 
Published: December 2019

Abstractμ‐Opioid receptors (μ‐ORs) play a critical role in the modulation of pain and mediate the effects of the most powerful analgesic drugs. Despite extensive efforts, it remains insufficiently understood how μ‐ORs produce specific effects in living cells. We developed new fluorescent ligands based on the μ‐OR antagonist E‐p‐nitrocinnamoylamino‐dihydrocodeinone (CACO), that display high affinity, long residence time and pronounced selectivity. Using these ligands, we achieved single‐molecule imaging of μ‐ORs on the surface of living cells at physiological expression levels. Our results reveal a high heterogeneity in the diffusion of μ‐ORs, with a relevant immobile fraction. Using a pair of fluorescent ligands of different color, we provide evidence that μ‐ORs interact with each other to form short‐lived homodimers on the plasma membrane. This approach provides a new strategy to investigate μ‐OR pharmacology at single‐molecule level.
Facile Synthesis of Hierarchical Nanosized Single‐Crystal Aluminophosphate Molecular Sieves from Highly Homogeneous and Concentrated Precursors
Authors: Tao Shuo , Li Xiaolei , Wang Xiaoge , Wei Ying , Jia Yunling , Ju Jing , Cheng Yuanhui , Wang Huaisheng , Gong Shuwen , Yao Xingjun , Gao Haixu , Zhang Cunyin , Zang Qiqi , Tian Zhijian 
Published: December 2019

AbstractThe synthesis of hierarchical nanosized zeolite materials without growth modifiers and mesoporogens remains a substantial challenge. Herein, we report a general synthetic approach to produce hierarchical nanosized single‐crystal aluminophosphate molecular sieves by preparing highly homogeneous and concentrated precursors and heating at elevated temperatures. Accordingly, aluminophosphate zeotypes of LTA (8‐rings), AEL (10‐rings), AFI (12‐rings), and ‐CLO (20‐rings) topologies, ranging from small to extra‐large pores, were synthesized. These materials show exceptional properties, including small crystallites (30–150 nm), good monodispersity, abundant mesopores, and excellent thermal stability. A time‐dependent study revealed a non‐classical crystallization pathway by particle attachment. This work opens a new avenue for the development of hierarchical nanosized zeolite materials and understanding their crystallization mechanism.
A Case for Bond‐Network Analysis in the Synthesis of Bridged Polycyclic Complex Molecules: Hetidine and Hetisine Diterpenoid Alkaloids
Authors: Doering Nicolle A. , Sarpong Richmond , Hoffmann Reinhard W. 
Published: December 2019

AbstractA key challenge in the synthesis of diterpenoid alkaloids lies in identifying strategies that rapidly construct their multiply bridged polycyclic skeletons. Existing approaches to these structurally intricate secondary metabolites are discussed in the context of a “bond‐network analysis” of molecular frameworks, which was originally devised by Corey some 40 years ago. The retrosynthesis plans that emerge from a topological analysis of the highly bridged frameworks of the diterpenoid alkaloids are discussed in the context of eight recent syntheses of hetidine and hetisine natural products and their derivatives. This Minireview highlights the extent to which network analyses of the type described here sufficed for designing synthesis plans, as well as areas where they had to be amalgamated with functional group oriented synthetic planning considerations.
Synthesis and characterization of thermosetting polyacetylene‐terminated silicone resins
Authors: Liu Zhongqi , Huang Yanchun , Deng Shifeng 
Published: December 2019

ABSTRACTA novel polyacetylene‐terminated silicone (PTS) resins possessing low curing temperature and high heat resistance has been prepared by Grignard reaction using m‐diacetylenylbenzene (DEB), 1,3,5‐triacetylenylbenzene(TEB), and dichlorosilane as original materials. The reaction of the functional groups was characterized by in situ Fourier transform infrared spectrometer. The experimental results indicated that Si─H and C≡CH bonds are almost exclusively involved in the crosslinking reaction, while ─C≡C─ bonds only partially react. Further, Si─H and C≡CH bonds can participate in the curing reaction at relatively low temperatures, but ─C≡C─ bonds require higher temperature, indicating the higher activity of Si─H and C≡CH bonds than ─C≡C─ bonds. As determined by differential scanning calorimetry, PTS resins have low peak exothermic temperature at 184.5 °C, which is lower than MSP resin (~ 210 °C); in addition, rheological test showed that PTS resins have a very wide processing window from 40 to 163.3 °C, indicating that the PTS resins have excellent processability with a low curing temperature and wide processing window. What is more, TGA results of thermal‐cured PTS resins revealed that Td5 (5% weight loss temperature) of PTS‐H10 reached the highest of 684.4 °C. Compared with PTS‐H0 resin, there is an increase of 124.2 °C and the remarkably increased heat resistance correlated with a higher m‐DEB input ratio. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48783.
Discovery of N‐pyridoyl‐Δ2‐pyrazolines as Hsp90 inhibitors
Authors: Kadasi Sundeep , Yerroju Ravali , Gaddam Swetha , Pullanagiri Nikhila , Chary Meghana , Pingili Divya , Raj Shiva , Raghavendra Nulgumnalli Manjunathaiah 
Published: December 2019

AbstractHsp90, as a key molecular chaperone, plays an important role in modulating the activity of many cell signaling proteins and is an attractive target for anticancer therapeutics. Herein, we report the discovery of N‐pyridoyl‐Δ2‐pyrazoline analogs as novel Hsp90 inhibitors by integrated approaches of drug design, organic synthesis, cell biology, and qualitative proteomic analysis. Novel chemical compounds were designed and optimized in the adenosine triphosphate‐binding site of Hsp90; lead optimized compounds were found to have significant interactions with Asp93 and other amino acids crucial for Hsp90 inhibition. The designed compounds were synthesized by a two‐step procedure; different aromatic aldehydes were reacted with various acetophenones to form substituted 1,3‐diphenyl‐prop‐2‐enones (Ic–Io), which upon reaction with isonicotinic acid hydrazide in the presence of glacial acetic acid form N‐pyridoyl‐Δ2‐pyrazoline compounds (PY1–PY13). Compounds PY3, PY2, and PY1 were identified as potential leads amongst the series, with promising anticancer activity against human breast cancer and melanoma cells, and the ability to inhibit Hsp90 similar to radicicol by drug‐affinity responsive target stability proteomic analysis in a whole‐cell assay.
Ancient Genomes Reveal Unexpected Horse Domestication and Management Dynamics
Authors: Orlando Ludovic 
Published: December 2019

AbstractThe horse was essential to past human societies but became a recreational animal during the twentieth century as the world became increasingly mechanized. As the author reviews here, recent studies of ancient genomes have revisited the understanding of horse domestication, from the very early stages to the most modern developments. They have uncovered several extinct lineages roaming the far ends of Eurasia some 4000 years ago. They have shown that the domestic horse has been significantly reshaped during the last millennium and experienced a sharp decline in genetic diversity within the last two centuries. At a time when no truly wild horses exist any longer, this calls for enhanced conservation in all endangered populations. These include the Przewalski's horse native to Mongolia, and the many local breeds side‐lined by the modern agenda, but yet representing the living heritage of over five millennia of horse breeding.
Jupiter microtubule‐associated homolog 1 (JPT1): A predictive and pharmacodynamic biomarker of metformin response in endometrial cancers
Authors: Bateman Nicholas W. , Teng Pang‐Ning , Hope Erica , Hood Brian L. , Oliver Julie , Ao Wei , Zhou Ming , Wang Guisong , Tommarello Domenic , Wilson Katlin , Litzy Tracy , Conrads Kelly A. , Hamilton Chad A. , Darcy Kathleen M. , Casablanca Yovanni , Maxwell George Larry , Bae‐Jump Victoria , Conrads Thomas P. 
Published: December 2019

AbstractPreoperative use of metformin in obese women with endometrioid endometrial cancer (EEC) reduces tumor proliferation and inhibits the mammalian target of rapamycin pathway, though is only effective in select cases. This study sought to identify a predictive and/or pharmacodynamic proteomic signature of metformin response to tailor its pharmacologic use. Matched pre‐ and post‐metformin‐treated tumor tissues from a recently completed preoperative window trial of metformin in EEC patients (ClinicalTrials.gov: NCT01911247) were analyzed by mass spectrometry (MS)‐based proteomic and immunohistochemical analyses. Jupiter microtubule‐associated homolog 1 (JPT1) was significantly elevated in metformin responders (n = 13) vs nonresponders (n = 7), and found to decrease in abundance in metformin responders following treatment; observations that were verified by immunohistochemical staining for JPT1. Metformin response and loss of JPT1 were assessed in RL95‐2 and ACI‐181 endometrial cancer (EC) cell lines. We further identified that silencing of JPT1 abundance does not alter cellular response to metformin or basal cell proliferation, but that JPT1 abundance does decrease in response to metformin treatment in RL95‐2 and ACI‐181 EC cell lines. These data suggest that JPT1 represents a predictive and pharmacodynamic biomarker of metformin response that, if validated in larger patient populations, may enable preoperative EEC patient stratification to metformin treatment and the ability to monitor patient response.