bluuebunny/crossref_metadata_2025_split huggingface dataset:
Germination: an alternative source to promote phytonutrients in edible seeds
Authors: Idowu Anthony Temitope , Olatunde Oladipupo Odunayo , Adekoya Ademola Ezekiel , Idowu Solomon 
Published: December 2019

Abstract
Consumption of less phytonutrient foods has shown to cause different chronic diseases, despite over 50,000 edible plant breed available in various countries around the globe. These edible plants consist of seeds that can be consumed which possessed high health benefits. Moreover, nutritive values such as phytochemicals of edible seeds increased after germination. Therefore, germination has been reported to enhance various bioactive compounds such as γ-amino butyric acid, polyphenols, and vitamins which lead to greater bioactivity such as anti-diabetic, anti-bacteria, and anti-cancer effects when these seeds are consumed. Consequently, germination can be regarded as a cheap and effective way to enhance the nutritional value of edible seeds.
INEQUALITIES IN HEALTHY AGING: THE DIFFERENTIAL IMPACT OF EDUCATION AND WEALTH ACROSS COHORT STUDIES
Authors: Wu Yu-Tzu , Daskalopoulou Christina , Terrera Graciela Muniz , Prince Martin , Prina Matthew 
Published: December 2019

Abstract
Several studies have investigated longitudinal changes in health status and functional ability but few have examined whether inequalities in healthy ageing varied across different countries. The aim of this study is to investigate trajectories of health metric scores (generated in previous symposium abstract) over the ageing process and examine the impact of education and wealth on the trajectories across eight cohorts in the ATHLOS consortium (N=135,828) using multilevel regression modelling. After adjusting for age, gender and study, higher levels of education (9.52; 95% CI: 9.30, 9.74) and wealth (8.06; 95% CI: 7.84, 8.28) were associated with higher baseline scores but had minimal impacts on decline rates. These effect sizes varied across different cohort studies and the inequality gradient was found to be strongest in the Health Retirement Study from US. Future research may investigate potential mechanisms which might explain the differential impact of education and wealth in different societies.
STAKEHOLDER ENGAGEMENT IN THE PLENARY AS A MODEL FOR PROFESSIONAL-COMMUNITY PARTNERSHIPS
Authors: Ansello Edward F , Marrs Sarah A , Waters Leland H 
Published: December 2019

Abstract
The Virginia Geriatric Education Center (VGEC), a consortium of four Virginia universities, directs all initiatives in its Geriatrics Workforce Enhancement Program (GWEP) through an “all-in” interprofessional model called the Plenary. Both the structure and the process of the Plenary can serve as a model for building and maintaining successful, interdisciplinary, and intersystem partnerships that work toward shared goals. In addition to faculty and staff from the four institutions who represent nine health professions, representatives from CBOs also serve on the Plenary and attend in-person meetings twice monthly to engage in a continuous, democratic, and hands-on PDSA (Plan-Do-Study-Act) cycle to improve GWEP programs. This allows our community partners to be engaged in all components of identifying and addressing unmet needs in current and emerging interprofessional gerontology and geriatrics training, increasing CBO’s stake in the overall success of the GWEP beyond their specific involvement. Team science principles guide program improvement and growth.
AMERICAN INDIAN FEMALE CAREGIVERS: STRESS AND RESILIENCE
Authors: Cordova-Marks Felina , Harris Robin , Teufel-Shone Nicolette , Norton Beatrice , Mastergeorge Ann , Cunningham James , Gerald Lynn 
Published: December 2019

Abstract
Background/Introduction: Increased stress has been found to be a part of the caregiving experience. However, how stress is handled is important. Resilience has been shown to decrease stress in non-caregivers. There is a lack of information about American Indian (AI) caregiver stress. In this study, we seek to investigate if resilience acts as a stress buffer in this population of AI female caregivers.Methods: The Hopi Adult Caregiver Survey was conducted in 2017 with 44 female Hopi caregivers. Resilience and stress scale questions were asked as well as variables potentially affecting these. Resilience as measured by the Connor Davidson Resilience Scale-10 (CD-RISC) and stress as measured by the Perceived Stress Scale-10 scores were calculated as well as categorical levels of higher and lower stress/resilience. Variables possibly associated with each were assessed using linear regression analyses. Results: Forty-four female caregivers were surveyed. The overall mean stress score for caregivers was 17.9 Â± 6.2 on the PSS. For difference between higher and lower stress, expectation of females to be caregivers, number of times using a traditional healer/traditional medicine person, number of caregiver difficulties, self-perceived health rating, self-perceived changes to eating habits since becoming a caregiver were significant. Average sum resilience score was 28.7 Â± 6.2 on the CD-RISC. In linear regression, it was found that with an increase in the resilience score, stress score decreased.Discussion: In these caregivers, resilience acts as a stress buffer. Increasing resilience and countering factors that decrease resilience may reduce stress experienced by caregivers.
BENEVOLENT AGEISM: THE CORRELATES OF OVERACCOMMODATION TOWARDS OLDER ADULTS
Authors: Sublett Jennifer F , Bisconti Toni L 
Published: December 2019

Abstract
Using the Stereotype Content Model as a framework for understanding ageism, our two objectives are (1) examining the predictive utility of benevolent ageism on well-being outcomes and (2) identifying conditional relationships between sex, perceived age, benevolent ageism, and well-being outcomes. In a snowball sample of 150 older adults who were 65 years old and older, we examined sex, perceived age, ageism, environmental mastery, and depression. Our benevolent ageism scale is an expanded version of the Ambivalent Ageism Scale that included additional items of accommodation created by us. Environmental mastery and depression were assessed by standard, internally valid, measures. Using regression analyses, we found that benevolent ageism predicted depression above and beyond hostile ageism. Additionally, benevolent ageism uniquely predicted environmental mastery for men, whereas hostile ageism uniquely predicted environmental mastery and depression for women. Finally, perceived age was a better predictor of well-being than chronological age. It is essential to consider how benevolent ageism relates to well-being due to the tenets of the Stereotype Content Model. Additionally, delineating the ways that sex and perceived age contribute to double jeopardy vs. crisis competence in the face of benevolence will lead to a more intricate understanding of the paths in which overaccommodative behaviors relate to well-being in older adulthood.
TELEPHONE-BASED COGNITIVE ASSESSMENTS IN A LARGE, MULTISITE RCT: THE COSMOS-MIND STUDY
Authors: Caudle Brad , Espeland Mark M , Rapp Stephen R , Shumaker Sally A , Pleasants Debbie , Baker Laura D 
Published: December 2019

Abstract
Identifying safe, affordable, and well-tolerated interventions that prevent or delay cognitive decline in older adults is of critical importance. There is growing evidence from basic science and small randomized trials that cocoa flavanols may provide protection against this decline. Funded by the NIA, COSMOS-Mind is an ancillary study of COSMOS and was designed to add cognitive outcomes to the parent study, a 2x2 factorial randomized controlled trial testing the effects of cocoa flavanols (600 mg/d) and a multivitamin with matching placebo on cardiovascular disease and cancer endpoints. A validated telephone-based protocol conducted at baseline and then annually for three years measures attention, memory, language, executive function, and global cognitive functioning in 2,262 women and men, ages 65 and older without insulin-dependent diabetes. Cases of mild cognitive impairment and Alzheimer’s and related dementias will be centrally adjudicated. For participants who score below a pre-specified threshold on a test of global cognition, a study partner is interviewed to obtain additional information regarding cognitive and functional status. With &gt;5,000 interviews completed, this presentation will describe the cognitive battery, operational procedures used to ensure high data fidelity, and strategies employed that have maintained retention at &gt;90%. Our experiences in COSMOS-Mind can inform the design and implementation of other large, multi-site RCTs and epidemiological studies. Telephone-based assessments of cognitive function are a cost-efficient method for assessing cognitive function.
A VIEW OF OLDER ADULTS’ DEMOGRAPHIC, HEALTH, AND ECONOMIC PROFILES BY RETIREMENT CHOICE STATUS
Authors: Tavares Jane L , Cohen Marc A 
Published: December 2019

Abstract
Gerontologist, economists, and other scientists have documented that involuntary or forced retirement is a more common occurrence among middle-aged adults than previously thought. Prevailing research has further indicated that involuntary retirement and off-time transitions are associated with poorer physical and mental well-being in later life. However, few studies have sought to gain a comprehensive understanding of who compromises the population of involuntary retirees and how these individuals compare to voluntary retirees. This study used the 2014 wave of the Health and Retirement Study (N=9,409) to analyze a United States representative sample of fully retired individuals aged 55 and older in order to develop a demographic, health, and economic profile of voluntary versus involuntary retirees. Analyses showed that that male, younger age group, minority race, separated/divorced, less educated, and south and west region residing individuals have significantly greater representation in the involuntary retirement group compared to the voluntary retirement group. Further, involuntary retirees reported significantly poorer physical and mental health and fewer financial resources than voluntary retirees. A supplementary longitudinal analyses also revealed that while health steadily declines for both of the retirement choice status groups, involuntary retirees maintained significantly poorer health than voluntary retirees over time. Observations from this study highlight the importance of identifying predictors of involuntary retirement and utilizing longitudinal analyses to gain greater insight into how health and economic characteristics factor into retirement decisions as well as how retirement decisions impact future health and economic characteristics.
CHRONIC DISEASE AND TERMINAL DECLINE IN VERY OLD MEN: THE MANITOBA FOLLOW-UP STUDY
Authors: Tate Robert B , John Philip St , Swift Audrey , Thompson Edward H 
Published: December 2019

Abstract
The Manitoba Follow-up Study is in its 71st year of continuous operation. Since 1948, 3,983 aircrew recruits to the Royal Canadian Air Force during the Second World War have submitted routine medical examinations and completed questionnaires. On May 1, 2006, 1001 of these men (25%) were alive mean age of 86 years. The effects of 7 chronic diseases (CDs) diagnosed before 2006 were modeled with multinomial logistic regression to predict the pattern of decline of living and dying through an 11 year window to 2017. By 2017, 11% were still alive, 10% died very early in the window, 44% experienced a slow decline of a least three years to death, 17% experienced a step decline to death, and 18% experienced a terminal drop, death within six months of decline in functioning. Only 30% were free of CD in 2006; 36% had 1 CD, and 34% had more than 1 CD. As the number of CDs increased, the probability of remaining alive by 2017 decreased: 18% alive if no CD, 10% if 1 CD, 8% if 2 CDs, and 3% of &gt;2 CDs. The chance of death with a terminal drop decreased: 22% if no CD, 20% if 1 CD, 14% if 2 CD, 11% if &gt;2 CD. Conversely, the percent with a gradual decline to death increased with more CDs. Among old men are already in their 80s, a key determinant of the trajectory to end of life is the number of CDs.
WECHAT, WERUN: A GROUP-BASED WALKING STUDY TO ENHANCE PHYSICAL ACTIVITY AMONG COMMUNITY-DWELLING OLDER ADULTS
Authors: Liu Yujun , Lachman Margie E 
Published: December 2019

Abstract
The benefits of physical activity (PA) and social engagement for older adults are well established, yet the majority of adults over age 50 in the U.S. do not engage in regular exercise. We conducted a 4-week pre-post study with a one-month follow-up using a smart phone application called WeChat WeRun to explore the mechanisms of social engagement and competition to increase PA among older adults. Participants (N=40, mean age=65.7) were randomly assigned to one of two conditions. Participants in the activity competition condition used the WeRun to track their daily walking steps and interact via text with their group members for 4 weeks. The daily walking steps were displayed to the group and the participant with the highest daily steps in the group was indicated as the champion each day. Participants in the control group only used WeRun to track their own walking steps. Outcome variables included average weekly steps, exercise self-efficacy, and social engagement. The two-way repeated measures ANOVA results revealed that participants in the competition condition had higher average weekly steps and level of social engagement at the posttest, compared to those in the control group. Post hoc tests using the Bonferroni corrections revealed that the intervention increased their average weekly steps and social engagement from pretest to post-test, while these outcomes did not change in the control group. The effects were maintained at the one-month follow up. Discussion will consider the motivational role of competition and social interactions in increasing PA among older adults.
CHANGES IN COGNITION ARE RELATED TO PERSONALITY CHANGES IN MIDDLE AND LATER ADULTHOOD
Authors: Liu Yujun , Lachman Margie E 
Published: December 2019

Abstract
Previous studies have identified an association between personality and cognition in later life. Those with more stable personalities have better cognitive functioning. And those with more cognitive decline have higher neuroticism. We examined the association between changes in both personality and cognition in the same model, which has not been systematically investigated. Data were from the Midlife in the United States (MIDUS) study, a national survey that included 4268 participants ages 35 to 85 at the second wave. The Big Five Personality traits and cognitive function variables (episodic memory and executive functioning) were from waves two and three. The analysis included a latent change score model and a cross-lagged panel design using Mplus. The results show that personality changes and cognitive changes over 9 years are correlated. Cross-lagged findings indicate that cognitive functioning is positively related to changes in conscientiousness, agreeableness, openness, and extraversion and negatively related to changes in neuroticism. The findings advance our understanding of the association between changes in personality and cognition. The impact of cognitive change on personality stability and the role of personality traits for maintaining cognitive function in later life are discussed. The results have implications for developing interventions to maintain or enhance cognitive functioning and personality in middle and later adulthood.
SOCIAL PARTICIPATION AND GENDER DISPARITY ON DEPRESSIVE SYMPTOMS AMONG INDONESIAN ELDERLY
Authors: Astuti Riska D , Sikoki Bondan 
Published: December 2019

Abstract
A voluminous literature empirically proves the significant relationship between social participation and elderly mental health. Further analysis discovers the different behavior between rural and urban elderly. Despite the importance of taking into account regional inequality, gender disparity which explains the inconsistent empirical results across countries, is sometimes negligible from the discussion. This study aims to investigate the link of social participation in voluntary activity and community regular meeting to depressive symptom among the elderly in Indonesia. Separated analysis based on gender is also conducted to examine the extent to which social activities could explain the depressive symptom disparity between male and female elderly. Data from Indonesia Family Life Survey 2007 and 2014 were analyzed using logistic regression. Sample of 2994 and 2917 respondents aged 60 and over in 2007 and 2014 respectively are combined as pooled cross-sectional data instead of panel data to deal with the large reduction of sample size due to mortality. To minimize the potential endogeneity, covariates are included in the model such as residence location, living arrangement, socio-economic status, and health condition. The results indicate that economic condition, chronic disease, and difficulty on instrumental activity daily living (IADL) play a significant role in depressive symptom among Indonesian elderly, regardless of the gender. Surprisingly, social participation that is widely believed in strengthening mental health is statistically significant for female sample only. Moreover, the contrast sign of voluntary participation and community regular meeting coefficients indicate a special behavior between these two activities.
THE FL-REACH PROJECT: TRANSLATING AN EBP FOR AN OUTPATIENT CLINICAL SETTING TO REACH DIVERSE COMMUNITY MEMBERS
Authors: Wharton Tracy C , Paulson Daniel , Laird Rosemary , Clark Judy , Shepherd Gayle , Bender Felicia 
Published: December 2019

Abstract
With more than 500,000 patients with Alzheimer’s disease, constituting nearly 10% of all cases in the US, the state of Florida spends an estimated $20 billion per year on care and treatment related to this disease. The Florida State Plan on Aging reported that 75% of informal caregivers felt that early education and training should be a high priority for the state, and that difficult behaviors and limited knowledge about dementias were among the most significant challenges that they faced. The REACH II intervention is the gold-standard for evidence-based practices that address burden, well-being, and skills training for dementia caregivers. This presentation describes the partnership of a Memory Disorder Clinic (MDC) team and two university-based researchers working to embed a modified REACH protocol into an outpatient clinic. Critical streamlined components and new material designed to innovations since the REACH trials. The FL-REACH protocol is significantly shorter, adds a structured assessment for both patient and family needs, expands to include advanced care planning and grief modules, and intentionally builds linkages to the medical care team, with a focus on outreach to diverse families. This manualized intervention is offered to families of patients diagnosed through the MDC, thus capitalizing on the rapport and trust that is built, and providing in-house opportunities to engage diverse populations with a program grounded in the evidence base. This intervention provides critical foundational training for families that will bridge to seamless team coordination in the future.
An analysis of antibiotic prescribing practices for enteric bacterial infections within FoodNet Canada sentinel sites
Authors: Dougherty Brendan , Finley Rita , Marshall Barbara , Dumoulin Danielle , Pavletic Amy , Dow Joanne , Hluchy Tara , Asplin Rod , Stone Jason 
Published: December 2019

AbstractObjectivesUnderstanding the current state of antibiotic treatment guidelines and prescribing practices for bacterial enteric infections is critical to inform antibiotic stewardship initiatives. This study aims to add to the current understanding through three objectives: (i) to identify and summarize published treatment guidelines for bacterial enteric infections; (ii) to describe observed antibiotic prescribing practices for bacterial enteric infections across three sentinel sites in Canada; and (iii) to assess concordance between observed antibiotic prescribing and treatment guidelines.MethodsAn environmental scan of treatment guidelines for bacterial enteric infections was conducted and recommendations were collated. A descriptive analysis of cases of bacterial enteric illnesses captured in FoodNet Canada’s sentinel site surveillance system between 2010 and 2018 was performed. Antibiotic-use data were self-reported by cases via an enhanced questionnaire.ResultsTen treatment guidelines were identified in the environmental scan. There was substantial variation between guidelines for both when to prescribe antibiotics and which antibiotics were recommended. Of the 5877 cases of laboratory-confirmed bacterial enteric illness in the three sites, 49% of cases reported having received an antibiotic prescription. Of particular significance was the finding that 21% of verotoxigenic Escherichia coli cases received a prescription. Of the 17 antibiotics recommended in the guidelines, 14 were used in practice. In addition to these, 18 other antibiotics not included in any of the guidelines reviewed were also prescribed.ConclusionsOur study suggests that a substantial proportion of enteric bacterial infections in Canada are prescribed antibiotics. These findings highlight the need to standardize treatment guidelines for enteric illnesses and could be used to inform future stewardship programme development.
Expression of AraC/XylS stress response regulators in two distinct carbapenem-resistant Enterobacter cloacae ST89 biotypes
Authors: Majewski Piotr , Gutowska Anna , Sacha Pawel , Schneiders Thamarai , Talalaj Mariola , Majewska Paulina , Zebrowska Agnieszka , Ojdana Dominika , Wieczorek Piotr , Hauschild Tomasz , Kowalczuk Oksana , Niklinski Jacek , Radziwon Piotr , Tryniszewska Elzbieta 
Published: December 2019

Abstract

Background
The growing incidence of MDR Gram-negative bacteria is a rapidly emerging challenge in modern medicine.

Objectives
We sought to establish the role of intrinsic drug-resistance regulators in combination with specific genetic mutations in 11 Enterobacter cloacae isolates obtained from a single patient within a 7 week period.

Methods
The molecular characterization of eight carbapenem-resistant and three carbapenem-susceptible E. cloacae ST89 isolates included expression-level analysis and WGS. Quantitative PCR included: (i) chromosomal cephalosporinase gene (ampC); (ii) membrane permeability factor genes, e.g. ompF, ompC, acrA, acrB and tolC; and (iii) intrinsic regulatory genes, e.g. ramA, ampR, rob, marA and soxS, which confer reductions in antibiotic susceptibility.

Results
In this study we describe the influence of the alterations in membrane permeability (ompF and ompC levels), intrinsic regulatory genes (ramA, marA, soxS) and intrinsic chromosomal cephalosporinase AmpC on reductions in carbapenem susceptibility of E. cloacae clinical isolates. Interestingly, only the first isolate possessed the acquired VIM-4 carbapenemase, which has been lost in subsequent isolates. The remaining XDR E. cloacae ST89 isolates presented complex carbapenem-resistance pathways, which included perturbations in permeability of bacterial membranes mediated by overexpression of ramA, encoding an AraC/XylS global regulator. Moreover, susceptible isolates differed significantly from other isolates in terms of marA down-regulation and soxS up-regulation.

Conclusions
Molecular mechanisms of resistance among carbapenem-resistant E. cloacae included production of acquired VIM-4 carbapenemase, significant alterations in membrane permeability due to increased expression of ramA, encoding an AraC/XylS global regulator, and the overproduction of chromosomal AmpC cephalosporinase.