bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular, serological, and biochemical diagnosis and monitoring of COVID-19: IFCC taskforce evaluation of the latest evidence
Authors: Bohn Mary Kathryn , Lippi Giuseppe , Horvath Andrea , Sethi Sunil , Koch David , Ferrari Maurizio , Wang Cheng-Bin , Mancini Nicasio , Steele Shannon , Adeli Khosrow 
Published: May 2020

Abstract
The global coronavirus disease 2019 (COVID-19) has presented major challenges for clinical laboratories, from initial diagnosis to patient monitoring and treatment. Initial response to this pandemic involved the development, production, and distribution of diagnostic molecular assays at an unprecedented rate, leading to minimal validation requirements and concerns regarding their diagnostic accuracy in clinical settings. In addition to molecular testing, serological assays to detect antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are now becoming available from numerous diagnostic manufacturers. In both cases, the lack of peer-reviewed data and regulatory oversight, combined with general misconceptions regarding their appropriate use, have highlighted the importance of laboratory professionals in robustly validating and evaluating these assays for appropriate clinical use. The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Task Force on COVID-19 has been established to synthesize up-to-date information on the epidemiology, pathogenesis, and laboratory diagnosis and monitoring of COVID-19, as well as to develop practical recommendations on the use of molecular, serological, and biochemical tests in disease diagnosis and management. This review summarizes the latest evidence and status of molecular, serological, and biochemical testing in COVID-19 and highlights some key considerations for clinical laboratories operating to support the global fight against this ongoing pandemic. Confidently this consolidated information provides a useful resource to laboratories and a reminder of the laboratory’s critical role as the world battles this unprecedented crisis.
Comparison the effects of inhalation and massage aromatherapy with lavender and sweet orange on fatigue in hemodialysis patients: a randomized clinical trial
Authors: Varaei Shokoh , Jalalian Zahra , Yekani Nejad Mir Saeed , Shamsizadeh Morteza 
Published: May 2020

Abstract

Objectives
Fatigue, regardless of the causes, could leave a negative impact on individual performance. The aim of this study was to compare the effects of inhalation and massage aromatherapy with lavender and sweet orange on fatigue among hemodialysis patients.

Methods
This study was a randomized controlled trial. The patients (96 patients) were allocated to three groups (control, an inhalation aromatherapy, and an aromatherapy massage group). A demographic questionnaire as well as the rhoten fatigue scale (RFS) was used to collect the data. The data were analyzed by descriptive and analytical statistics using SPSS version 18.

Results
Before the intervention, there was no significant difference among the groups regarding fatigue level (p=0.54). However, eight and 16 weeks after the study, the levels of fatigue in both experimental groups were significantly lower than the control group (p < 0.05).

Conclusions
Interventions with essential oils are effective in reducing fatigue in hemodialysis patients, although the effects of aromatherapy massage on fatigue are stronger than the effects of inhalation aromatherapy.
Preparation of skeletally diverse quinazoline-2,4(1H,3H)-diones using Na2SiO3/SnFe2O4 catalytic system through a four-component reaction
Authors: Ayambekam Fazilat , Ghashang Majid 
Published: May 2020

Abstract
Sodium silicate with the formula of Na2SiO3 was used for the four-component reaction of ketones, aldehydes and cyanoacetamide. The effect of SnFe2O4 nano-particles on the catalytic potential of Na2SiO3 was investigated. The desired products synthesized by this method are 5-amino-7-aryl-2,4-dioxo-2,3,4,4a,7,7a,8,9,10,11-decahydro-1H-benzo[i]quinazoline-6-carbonitriles, 5-amino-2,4-dioxo-7-aryl-1,2,3,4,4a,7,7a,8,10,11-decahydropyrano[3,4-i] quinazoline-6-carbonitrile, 5-amino-9-methyl-2,4-dioxo-7-aryl-2,3,4,4a,7,7a,8,9,10,11-decahydro-1H-pyrido[3,4-i] quinazoline-6-carbonitrile and 5-amino-2,4-dioxo-7-aryl-1,2,3,4,4a,7,7a,8,10,11-decahydrothiopyrano[3,4-i]quinazo-line-6-carbonitrile derivatives. This method has advantages of high yields, simple procedure and easy work-up.
Negative Dialectics before Object-Oriented Philosophy: Negation and Event
Authors: Novis Kenneth 
Published: May 2020

AbstractAn important question in Object-Oriented Ontology (OOO) and its associated literature is how OOO relates to its competitor theories. This article is a meta-philosophical investigation into OOO and its grounding, which hopes to fully theorise this relation, deriving ultimately a “negative dialectic” that emphasises the irreducible differences between OOO and non-OOO. Beginning by analysing the use of OOO as a “starting point”, I consider Althusser’s various contributions to meta-philosophical debates. This leads me to focus on Harman’s notion of “hyperbolic reading”, and on how attempts to hyperbolically ground OOO force it to immanently include its competitors. Finally, I apply these insights to systematise both the negative dialectical relation between OOO and non-OOO and the becoming-OOO of thinking, by applying Laruelle’s Non-Philosophy.
The sociology of sport in Spain: Development, current situation, and future challenges
Authors: Sánchez-García Raúl , Moscoso-Sánchez David , Piedra Joaquín 
Published: May 2020

SummaryThis article presents the development and current situation of the sociology of sport in Spain. It begins with a brief description of its origins and development as an academic field, which can be divided into three stages: birth, growth, and consolidation and internationalization. It then describes the theoretical and methodological traditions as well as the predominant topics (including the most representative research) in the social scientific studies on physical activity conducted so far in Spain. The main topics have been sports in society, sports controversies, the social sports structure, sports identities and spaces for practicing sports, organization, management, and the job market. The article concludes with an analysis of the possible future challenges for the sociology of sport in Spain and the role that the journalSociología del Deporte(Sociology of Sport) can play in view of these challenges.
Wie weit trägt der Dritte Weg? Gegenwärtige Entwicklungstendenzen der arbeitsmarktpolitischen Programmatik der SPD
Authors: Illan Luis 
Published: May 2020

AbstractDie Orientierung an einem „Dritten Weg“ führte um die Jahrtausendwende zu einer tiefgreifenden Neujustierung sozialdemokratischer Programmatiken. Mit Blick auf den Bereich der Arbeitsmarktpolitik markierte dies eine Hinwendung zum Leitbild eines aktivierenden Wohlfahrtsstaates. Nach anfänglichen Wahlerfolgen legen nun jedoch auch wissenschaftliche Beobachter/-innen nahe, in dieser Reformpolitik einen Grund für die derzeitige Krise der Sozialdemokratie zu sehen. Zugleich fallen auch führende Politiker der SPD in jüngster Zeit durch Bemühungen auf, die Partei vom ehemaligen Reformkurs während der Kanzlerschaft Gerhard Schröders zu distanzieren. Der Artikel untersucht, inwiefern dies zu einer programmatischen Abkehr der SPD vom Dritten Weg mit Blick auf arbeitsmarktpolitische Positionen führt.
Uni-Port Total Thoracoscopic Surgery Versus Median Sternotomy for Redo Tricuspid Valve Replacement: A Retrospective Study
Authors: Yan Licheng , Zheng Fuzhen , Chen Haiyu , Bao Jiayin , Weng Guoxing 
Published: May 2020

Background: This study compared the perioperative and follow-up period data of patients who underwent redo tricuspid valve replacements performed via thoracoscopic surgery or median sternotomy. The purpose was to evaluate the feasibility, safety, and surgical outcomes of redo tricuspid valve replacement via uni-port thoracoscopic surgery.
Methods: Forty-nine patients with severe tricuspid valve regurgitation after left-side valve replacement underwent redo tricuspid valve replacements in our hospital from April 2012 to September 2019. Twenty-six patients underwent uni-port total thoracoscopy surgery, whereas 23 patients had the surgery performed via median sternotomy. We collected perioperative and 3- to 36-month postoperative data.
Results: No deaths occurred in the intraoperative period. Time of cardiopulmonary bypass in the study group significantly was longer than that in the control group (P < .05), but the operative times in the study and control groups were not significantly different. Thoracic drainage, length of ICU stay, postoperative hospital stay, and complication rates in the study group were significantly different from those in the control group (P < .05). Throughout the follow-up period, uni-port total thoracoscopic TVR was not inferior to traditional surgery with respect to cardiac function and recurrence of tricuspid valve regurgitation.
Conclusions: Uni-port total thoracoscopic tricuspid valve replacement is safe, feasible and effective, and that can be considered as a primary treatment strategy for patients with severe TR after previous left-sided valve procedure.
Cash means control
Authors: Bogodistov Yevgen , Moormann Jürgen 
Published: May 2020

Purpose – to investigate reasons and conditions impacting payment preferences.
Design/Method/Approach. In this exploratory study, we apply the Implicit Association Test in order to investigate whether the prejudice of the population of some countries such as Germany preferring cash holds.
Findings. Cash payments still play a major role in a number of countries although other payment options, namely card payments, are promoted heavily. We discover that the type of payment and the level of control are implicitly associated. We manipulate the emotions of fear and joy. The relationship changes when participants experience fear, whereas emotion of joy does not produce statistically significant effects.
Practical implications. The results have major implications for the design of payment processes.
Originality/Value. Our study helps explain preferences with regard to payment types as well as predict preferences as a response to scary or joyful events.
Research limitations/Future research. Generalizability is limited. Future research can focus on other emotions and types of payment (e.g., NFC – based payments).
Paper type – empirical.
A Phase II Trial of Cabozantinib in Hormone Receptor-Positive Breast Cancer with Bone Metastases
Authors: Xu Jing , Higgins Michaela J. , Tolaney Sara M. , Come Steven E. , Smith Matthew R. , Fornier Monica , Mahmood Umar , Baselga Jose , Yeap Beow Y. , Chabner Bruce A. , Isakoff Steven J. 
Published: May 2020

Abstract

Background
We assessed the antitumor activity of cabozantinib, a potent multireceptor oral tyrosine kinase inhibitor, in patients with hormone receptor-positive breast cancer with bone metastases.

Patients and Methods
In this single-arm multicenter phase II study, patients received an initial starting dose of 100 mg, later reduced to 60 mg, per day. The primary endpoint was the bone scan response rate. Secondary endpoints included objective response rate by RECIST, progression-free survival (PFS), and overall survival (OS).

Results
Of 52 women enrolled, 20 (38%) experienced a partial response on bone scan and 6 (12%) had stable disease. Prior to the first repeat bone scan at 12 weeks, 19 (35%) patients discontinued study treatment because of early clinical progression or unacceptable toxicity. RECIST evaluation based on best overall response by computed tomography revealed stable disease in extraosseous tissues in 26 patients (50%) but no complete or partial responses. In 25 patients with disease control on bone scan at 12 weeks, only 3 (12%) patients developed extraosseous progression. The median PFS was 4.3 months, and median OS was 19.6 months. The most common grade 3 or 4 toxicities were hypertension (10%), anorexia (6%), diarrhea (6%), fatigue (4%), and hypophosphatemia (4%).

Conclusion
Bone scans improved in 38% of patients with metastatic hormone receptor-positive breast cancer and remained stable in an additional 12% for a minimum duration of 12 weeks on cabozantinib. Further investigations should assess the activity of cabozantinib in combination with other hormonal and other breast cancer therapies and determine whether bone scan responses correlate with meaningful antitumor effects. ClinicalTrials.gov identifier. NCT01441947

Implications for Practice
Most patients with metastatic hormone receptor-positive (HR+) breast cancer have bone involvement, and many have bone-only disease, which is difficult to evaluate for response. This phase II single-arm study evaluated the clinical activity of the small molecule MET/RET/VEGFR2 inhibitor cabozantinib in patients with metastatic HR+ breast cancer with bone metastases. This study met its primary endpoint, and cabozantinib treatment resulted in a significant bone scan response rate correlating with improved survival. This is the first study to use bone scan response as a primary endpoint in breast cancer. The results support further study of cabozantinib in HR+ breast cancer.
Correlação entre dois testes e a pontuação do Child Health Assessment Questionnaire em crianças com cardiopatia reumática
Authors: Gonçalves Fernanda Souza , Moreira de Almeida Suzana Souza , Santos Juliana Costa , Mendes Carlos Maurício Cardeal 
Published: May 2020

INTRODUÇÃO: As crianças que evoluem para cardiopatia reumática passam a conviver com limitações, tornam-se comumente restritas no desempenho de atividade do cotidiano. OBJETIVO Verificar a existência de correlação entre o desempenho no teste de caminhada de seis minutos (TC6M) e do degrau de três minutos (TD3) e a pontuação do child health assessment questionnaire (CHAQ) em criança com febre reumática. MÉTODOS: Estudo seccional sem grupo de comparação, descritivo e exploratório, realizado com 15 crianças. Foram avaliadas através dos testes submáximos, o TC6M e o TD3 e a avaliação da capacidade física sob a percepção do cuidador foi realizada por meio da aplicação do CHAQ . RESULTADOS: A média de idade 13,7 anos, desvio padrão 1,9 anos. A maioria dos acompanhantes eram mães, 66,7%, e uma parcela considerável dos cuidadores apresentou baixo nível socioeconômico e de escolaridade. O valor obtido na distância percorrida através do TC6M demonstrou um baixo desempenho, mediana (intervalo interquartil) 420 (101) metros que também foi observado no teste do degrau de três minutos, mediana (intervalo interquartil) 68 (6,5) degraus. Em relação ao questionário CHAQ foi observado ausência de comprometimento da capacidade física diante da percepção dos responsáveis com escore final do questionário de 0,1. A correlação entre o questionário e o teste de caminhada de seis minutos (correlação de Sperman = - 0,21) e, entre o questionário e o teste do degrau de três minutos, (correlação de Sperman = - 0,39). CONCLUSÃO: Não foi encontrada correlação dos testes submáximos, em relação à capacidade física obtida através da percepção dos responsáveis avaliada através do questionário. Esse resultado chama a atenção para a importância do fisioterapeuta inserir na sua prática clínica, nesse perfil de pacientes os testes submáximos.
Six Degree-of-Freedom Broadband Ground-Motion Observations with Portable Sensors: Validation, Local Earthquakes, and Signal Processing
Authors: Yuan Shihao , Simonelli Andreino , Lin Chin-Jen , Bernauer Felix , Donner Stefanie , Braun Thomas , Wassermann Joachim , Igel Heiner 
Published: May 2020

ABSTRACTThe additional observation of three components of rotational ground motions has benefits for tilt-seismometer coupling (e.g., ocean-bottom seismometry and volcano seismology), local site characterization, wavefield separation, source inversion, glacial and planetary seismology, as well as the monitoring of structural health. Field applications have been mostly hampered by the lack of portable sensors with appropriate broadband operation range and weak-motion sensitivity. Here, we present field observations of the first commercial portable broadband rotation sensor specifically designed for seismology. The sensor is a three-component fiber-optic gyro strictly sensitive to ground rotation only. The sensor field performance and records are validated by comparing it with both array-derived rotation measurements and a navigation-type gyro. We present observations of the 2018 Mw 5.4 Hualien earthquake and the 2016 central Italy earthquake sequence. Processing collocated rotation and classical translation records shows the potential in retrieving wave propagation direction and local structural velocity from point measurements comparable to small-scale arrays of seismic stations. We consider the availability of a portable, broadband, high sensitivity, and low self-noise rotation sensor to be a milestone in seismic instrumentation. Complete and accurate ground-motion observations (assuming a rigid base plate) are possible in the near, local, or regional field, opening up a wide range of seismological applications.
Dominant factors on selection of contraception toward new family planning acceptors in public health center area in Padang
Authors: Rahmatiqa Chamy , Patricia Helena 
Published: May 2020

Background: The use of family planning or as known as KB in Indonesia from 1970 to 2017 has increased significantly. The most use of KB in non MKJP was injection 70% and pill 21%. The use of this method was very influential on the level of family planning continuity. Viewed from the 2012 SDKI, the dropout rate in the injection method was 40.7%. This phenomenon has contributed to the stagnation of the total fertility rate and ultimately still impact to the high maternal mortality rate in Indonesia.Methods: This analytic study was conducted with a cross sectional approach. The populations in this study were all new family planning acceptors and samples of 114 people were taken by random sampling technique. The data collection was a questionnaire with data analysis using chi-square test.Results: More types of contraception were non MKJP (66.4%), more early adult age (60.8%), education level was more than half of low education (54.4%), and most of the mothers were unemployed (76.8). The parity were more than 1 and 2 children (52.8%), more contraceptive goals who did not want their children (60%), and the low support of their husbands was more than the high support of their husbands (55%). There was a relationship between age, education level, work status, parity, contraceptive goals, and husband support with the selection of contraceptive methods in new family planning acceptors.Conclusions: The dominant factor on selection of contraception toward new family planning acceptors was husband support.
Assisted dying and voluntary euthanasia: awareness and perception among health care professionals in a tertiary care centre, South India
Authors: Kothari Ashutosh , Premarajan K. C. , Adinarayanan Sethuramachandran 
Published: May 2020

Background: On March 2018, the supreme court of India adjudicated passive euthanasia legal which was termed as obsolete by Indian Council of Medical Research. There are varied opinions because of difference in terminologies used in the country. As per the current Indian legislations, the procedure of voluntary euthanasia and assisted dying is illegal. Hence, this study aims in understanding the awareness and perception towards the same. Methods: A descriptive cross-sectional study was conducted among all the 369 health care professionals employed in the selected departments of a tertiary care institute during the study period. The questionnaire used was content validated and pre-tested before administering it to the participants. It consisted of five domains (in a five-point Likert scale) and were summarized as proportions.Results: Most of the doctors (64%) and nurses (59.3%) said that euthanasia is illegal in India. About one fourth of the responders encountered a situation where the patient asked for assisted dying or voluntary euthanasia. A total of 65.3% of the participants agreed that it is helping the patient to die and not killing them.Conclusions: The study demonstrated that the health care professionals had favourable responses for half of the statements. Re-looking into the verdict by the supreme court of India, standardising the terminologies and advocating for ‘advance medical directive’ would be welcoming steps in deciding the future of assisted dying/voluntary euthanasia in the country.
DETERMINANTS OF ENTREPRENEURIAL INTENTIONS: TECHNICAL VOCATIONAL EDUCATION AND TRAINING (TVET) IN SRI LANKA
Authors: Perera HTUK , Nishantha B 
Published: May 2020

Purpose of the study: This study is focused to investigate the determinants of the entrepreneurial intention of Technical Vocational Education and Training (TVET) students in Sri Lanka.
Methodology: The research model comprises seven independent variables i.e. entrepreneurial attitude, perceived self-efficacy, social capital, demographic factors, perceived financial support, perceived regulatory support, perceived technical vocational education, and training and dependent variables of entrepreneurial intention. The primary data was collected through administering structured questionnaires among a hundred and twenty-eight TVET students represented by three TVET sector institutions in Sri Lanka. Linear regression was applied to test the hypotheses.
Main Findings: The findings of the study revealed a positive and significant impact of the variables of entrepreneurial attitudes and perceived technical vocational education and training on entrepreneurial intention of TVET students of Sri Lanka. TVET student attitudes pertaining to entrepreneurship intention are positive since they perceive that TVET enhances their entrepreneurship education and this is very important to the policymakers in entrepreneurship development to initiate effective strategies to foster entrepreneurship for TVET students.
Implications: This research study provides an academic contribution to enhance the entrepreneurial intention among the TVET students in Sri Lanka.
Mortalidad materna en el Instituto Materno Infantil de Bogotá años: 1981-1982
Authors: Becerra Corredor Epifanio 
Published: May 2020

La tasa de mortalidad materna es un fiel indicador de la calidad de los programas que en atención a la embarazada brinda un país o un organismo de salud determinado. Es posible deducir a través de esta tasa el desarrollo cultural, social, económico y tecnológico alcanzado en el lugar donde se analizan sus resultados, (6, 14).