bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of an incentive‐based prenatal smoking cessation program for low‐income women in Colorado
Authors: Polinski Kristen J. , Wolfe Rachel , Peterson Anne , Juhl Ashley , Perraillon Marcelo Coca , Levinson Arnold H. , Crume Tessa L. 
Published: November 2019

AbstractObjectiveTo assess birth outcomes and cost‐savings of an incentive‐based prenatal smoking cessation program targeting low‐income women in Colorado.DesignProspective observational cohort with nonequivalent population control groups.SampleProgram participants (n = 2,231) linked to the birth certificate to ascertain birth outcomes compared to two reference populations from Pregnancy Risk Assessment Monitoring System (PRAMS) and Colorado live births based on the birth certificate.MeasurementsTobacco cessation metrics in the third trimester of pregnancy, neonatal low birth weight (<2,500 g), preterm birth (birth at <37 weeks gestation), neonatal intensive care unit (NICU) admission and maternal gestational hypertension. Cost‐savings and return on investment (ROI) were projected using average Medicaid reimbursement.ResultsInfants of mothers enrolled in the program had a lower risk of low birthweight (RR = 0.86; 95% CI = 0.75, 0.97), preterm birth (PTB) (RR = 0.76; 95% CI = 0.65, 0.88) and neonatal intensive care unit (NICU) admission (RR = 0.76; 95% CI = 0.66, 0.88) compared to the birth certificate population, corresponding to a ROI of $7.73 and an individual cost savings of $6,040. Compared to PRAMS, infants of enrolled mothers had a lower risk of PTB (RR = 0.72; 95% CI = 0.53, 0.99) and NICU admission (RR = 0.45; 95% CI = 0.32, 0.62), corresponding to an ROI of $2.79 and an individual cost savings of $2,182.ConclusionsWe found a reduction of adverse birth outcomes, and cost savings.
Strained, Photoejecting Ru(II) Complexes that are Cytotoxic Under Hypoxic Conditions
Authors: Roque John , Havrylyuk Dmytro , Barrett Patrick C. , Sainuddin Tariq , McCain Julia , Colón Katsuya , Sparks William T. , Bradner Evan , Monro Susan , Heidary David , Cameron Colin G. , Glazer Edith C. , McFarland Sherri A. 
Published: November 2019

AbstractA series of strained Ru(II) complexes were studied for potential anticancer activity in hypoxic tissues. The complexes were constructed with methylated ligands that were photolabile and an imidizo[4,5‐f][1,10]phenanthroline ligand that contained an appended aromatic group to potentially allow for contributions of ligand‐centered excited states. A systematic variation of the size and energy of the aromatic group was performed using systems containing 1–4 fused rings, and the photochemical and photobiological behaviors of all complexes were assessed. The structure and nature of the aromatic group had a subtle impact on photochemistry, altering environmental sensitivity, and had a significant impact on cellular cytotoxicity and photobiology. Up to 5‐fold differences in cytotoxicity were observed in the absence of light activation; this rose to 50‐fold differences upon exposure to 453 nm light. Most significantly, one complex retained activity under conditions with 1% O2, which is used to induce hypoxic changes. This system exhibited a photocytotoxicity index (PI) of 15, which is in marked contrast to most other Ru(II) complexes, including those designed for O2‐independent mechanisms of action.
Arabidopsis nucleoporin CPR5 controls trichome cell death through the core cell cycle regulator CKI
Authors: Peng S. , Sun K. , Guo Y. , Liu Y. , Wang S. 
Published: November 2019

Abstract

The Arabidopsis trichome is a polyploid epidermal cell resulting from multiple rounds of endocycles. The CYCLIN‐DEPENDENT KINASE INHIBITOR (CKI) family proteins are core cell cycle regulators that promote the endocycle. CONSTITUTIVE EXPRESSION OF PR GENES 5 (CPR5) is a plant‐specific nucleoporin. It has been found that two Arabidopsis CKI, SIAMESE (SIM) and SIAMESE‐RELATED 1 (SMR1), function downstream of CPR5 to activate plant effector‐triggered cell death. The sim smr1 double mutants form multicellular and clustered trichomes, while the cpr5 mutants produce dead and branchless trichomes. This study explored roles of the CPR5‐CKI signalling pathway in trichome cell cycle transition.

To examine the underlying mechanism of how cell cycle transition is regulated in plant trichomes, Trypan blue staining, flow cytometry, scanning electron microscopy (SEM) and nuclear DNA measurement were conducted.

The native promoter‐driven CKI and GUS fusion reporter showed that both SIM and SMR1 proteins were preferentially expressed in trichomes. The cpr5‐induced dead and branchless trichomes were fully suppressed by the sim smr1 double mutant, suggesting that SIM and SMR1 function downstream of CPR5 in trichome development. Flow cytometry analysis showed that as compared to the number of 2C (C = DNA content in a haploid nucleus) cells, the number of 4C cells significantly increased, whereas that of polyploidy cells (8C and 16C) dramatically decreased in the cpr5 mutant. The elevated 4C/2C ratio in the cpr5 mutant is consistent with de‐repression of pro‐endocycle regulators SIM and SMR1. The polyploidy cells (8C and 16C) may be selectively targeted to cell death, which is therefore attributed to the branchless trichomes in the cpr5 mutant. Nuclear DNA content analysis demonstrated that the nuclear DNA content of trichomes in the cpr5 sim mutant was significantly higher than in the sim mutant, indicating that CPR5 is a negative endocycle regulator in trichomes.

This study reveals that the CPR5‐CKI signalling pathway controls trichome cell cycle transition and excessive endocycles are required for cell death in plant trichomes.
Status and recommendations for sustainable freshwater aquaculture in Brazil
Authors: Nobile André B. , Cunico Almir M. , Vitule Jean R. S. , Queiroz Jamile , Vidotto‐Magnoni Ana P. , Garcia Diego A. Z. , Orsi Mário L. , Lima Felipe P. , Acosta Aline A. , da Silva Reinaldo J. , do Prado Fernanda D. , Porto‐Foresti Fábio , Brandão Heleno , Foresti Fausto , Oliveira Claudio , Ramos Igor P. 
Published: November 2019

AbstractBrazil is a megadiverse country and is participant of fundamental environmental agreements for biodiversity conservation. However, the internal politics and the cultures that affect negatively the ecological integrity in Brazilian freshwater need to be improved on the condition of sustainable management. Scientific community, the government and stakeholders are in constant conflicts of goals. Meanwhile, the current model for Brazilian aquaculture shows problems of ecological impact due to the lack of appropriated planning and legislation to the aquatic biota. The non‐recognition of sustainable census incorporated in its environmental politics reflects in an archaic and unsustainable management, with the following characters: a non‐specific approach for technical management, the indiscriminate use of interspecific hybrids and non‐native species and the lack of skilled labour. The potential impact on native species and the introduction of pathogens are the main negative effects on aquatic biota. This way, the aim of this article is to elucidate the conflicts of interests and ecological effects of fish aquaculture in Brazil, besides providing good practices and sustainable alternatives for management.
Penal and welfare conditionality: Discipline or degradation?
Authors: McNeill Fergus 
Published: November 2019

AbstractThis paper aims to complement analyses of welfare conditionality by examining what can be learned from studies of conditional punishment in the criminal justice system. Drawing on a range of recent studies, I explore lived experiences of the conditionality attendant on penal forms of supervision; penal forms that have expanded rapidly in recent decades. I argue that, to paraphrase Stan Cohen, such supervision is as much about the dispersal of degradation as it is about the dispersal of discipline. Indeed, in contemporary western societies, both in punishment and in welfare systems, I suggest that conditionality functions less to discipline poor and marginalised people and more to disqualify them from the entitlements of ordinary citizenship. In so doing, conditionality constructs them as denizens, thus serving to limit the liabilities for the state that arise from social inequalities. Extending Delroy Fletcher and Sharon Wright's metaphor, the abusive slaps now meted out in concert by both hands of the penal state are as much about degrading and denying the entitlements of “needy” denizens as they are about influencing their conduct. But crucially, even within the increasingly restrictive context created by these developments, penal practitioners can and do provide care and assistance.
Gender differences in nutritional status, diet and physical activity among adolescents in eight countries in sub‐Saharan Africa
Authors: Darling Anne Marie , Sunguya Bruno , Ismail Abbas , Manu Abubakar , Canavan Chelsey , Assefa Nega , Sie Ali , Fawzi Wafaie , Sudfeld Chris , Guwattude David 
Published: November 2019

AbstractObjectiveThe objective of this study was to evaluate gender differences in nutritional status, dietary intake, physical activity and hand hygiene among adolescents from diverse geographical settings in sub‐Saharan Africa.MethodsThis study utilised cross‐sectional data from six countries (Burkina Faso, Ethiopia, Ghana, Nigeria, Tanzania and Uganda) within the ARISE Adolescent Health Survey (n = 7625). Body mass index (BMI) was calculated using measured heights and weights, and z‐scores were calculated based on the 2007 WHO growth standards for age and sex. Information on demographics, diet and health behaviours was collected through face‐to‐face interviews using a standardised questionnaire. Site‐specific and pooled prevalence ratios were determined.ResultsThe prevalence of underweight, overweight and stunting pooled across sites was 14.3%, 6.8% and 18.1%, respectively. Female sex was associated with a lower risk of being underweight (pooled prevalence ratio 0.66, 95% 0.57, 0.77) and stunted (pooled PR 0.63, 95% CI 0.55, 0.71), but a higher risk of being overweight (pooled PR 1.60, 95% CI 1.26, 2.06). Females were also less likely to exercise for 1 h or more per day (pooled PR 0.77, 95% CI 0.67, 0.88), and more likely to wash hands after using toilets or latrines and to wash hands with soap (pooled PRs 1.13, 95% CI 1.05, 1.21 and 1.35, 95% CI 1.23, 1.45, respectively).ConclusionOur results emphasise that sex is a key predictor of nutritional status among sub‐Saharan African adolescents and suggest that gender‐specific interventions may be required to reduce the double burden of under‐ and overnutrition.
From Event Representation to Linguistic Meaning
Authors: Ünal Ercenur , Ji Yue , Papafragou Anna 
Published: November 2019

AbstractA fundamental aspect of human cognition is the ability to parse our constantly unfolding experience into meaningful representations of dynamic events and to communicate about these events with others. How do we communicate about events we have experienced? Influential theories of language production assume that the formulation and articulation of a linguistic message is preceded by preverbal apprehension that captures core aspects of the event. Yet the nature of these preverbal event representations and the way they are mapped onto language are currently not well understood. Here, we review recent evidence on the link between event conceptualization and language, focusing on two core aspects of event representation: event roles and event boundaries. Empirical evidence in both domains shows that the cognitive representation of events aligns with the way these aspects of events are encoded in language, providing support for the presence of deep homologies between linguistic and cognitive event structure.
Photoperiod sensing of the circadian clock is controlled by EARLY FLOWERING 3 and GIGANTEA
Authors: Anwer Muhammad Usman , Davis Amanda , Davis Seth Jon , Quint Marcel 
Published: November 2019

SummaryELF3 and GI are two important components of the Arabidopsis circadian clock. They are not only essential for the oscillator function but are also pivotal in mediating light inputs to the oscillator. Lack of either results in a defective oscillator causing severely compromised output pathways, such as photoperiodic flowering and hypocotyl elongation. Although single loss of function mutants of ELF3 and GI have been well studied, their genetic interaction remains unclear. We generated an elf3 gi double mutant to study their genetic relationship in clock‐controlled growth and phase transition phenotypes. We found that ELF3 and GI repress growth differentially during the night and the day, respectively. Circadian clock assays revealed that ELF3 and GI are essential that enable the oscillator to synchronize the endogenous cellular mechanisms to external environmental signals. In their absence, the circadian oscillator fails to synchronize to the light–dark cycles even under diurnal conditions. Consequently, clock‐mediated photoperiod‐responsive growth and development are completely lost in plants lacking both genes, suggesting that ELF3 and GI together convey photoperiod sensing to the central oscillator. Since ELF3 and GI are conserved across flowering plants and represent important breeding and domestication targets, our data highlight the possibility of developing photoperiod‐insensitive crops by adjusting the allelic combination of these two key genes.
Control of Period-Doubling and Chaos in Varying Compliance Resonances for a Ball Bearing
Authors: Zhang Zhiyong , Rui Xiaoting , Yang Rui , Chen Yushu 
Published: November 2019

AbstractVarying compliance (VC) is an inevitable parametrical excitation to rolling bearing systems due to time-varying stiffness from rolling element revolution. Period-doubling instability in the VC primary resonances of ball bearing is presented in many studies. Recently, this instability was demonstrated to be a probable indicator of occurrence of strong one to two internal resonances and chaotic motions, which has potential effects on the stability and safety of the bearing-rotor system. However, few studies have directly attempted to suppress this bifurcation instability. Here, a dynamic stiffness evaluating method is presented for assessing the threshold of the period-doubling and complex motions in VC primary resonances of ball bearings, where the elaborate evolution of the bifurcating process is obtained by harmonic balance and alternating frequency/time domain (HB-AFT) method and using Floquet theory. Our analysis indicates that by introducing certain additional stiffness, the period-doubling and corresponding subharmonic internal resonances can be suppressed. Besides, the evolution and mechanism of type I intermittency chaos in ball bearings will be clarified in depth. It is also shown that extensive chaotic motions for large bearing clearances (e.g., 40 μm) can vanish perfectly by action of additional stiffness.
Dynamic Performance Optimization of a Novel 8-SPU Parallel Walking Mechanism
Authors: Wan Xiao-Jin , Yang Junqiang , Zhang Yan 
Published: November 2019

Abstract
Dynamic performance as one of the important properties of the parallel mechanism cannot be ignored, which is usually illustrated through dynamic performance analysis with the aid of index. Therefore, to develop reasonable dynamic performance indices is of great theoretical and practical significance for the parallel mechanism. In this paper, the above issues are discussed by taking the parallel mechanism designed by our research group as a study object. First, on the basis of considering the driving motor, kinematics dexterity and dynamic dexterity based on the global kinematics condition index and the global dynamic condition index are analyzed, respectively, in the workspace. Second, a novel diagonally dominant index (DDI) is presented in terms of the equivalent inertia parameter in joint space, and the proposed approach gives full consideration to minimize the inter-chain coupling effects. Furthermore, the parallel mechanism is optimized by means of taking the volume of the workspace, the global kinematics condition index, the global dynamic condition index, and the diagonally dominant index as objective functions. The optimization result shows that the larger workspace, higher dexterity, and smaller DDI are obtained to further improve the work capability and dynamic property of the mechanism. Finally, a real and novel 8-SPU (spherical pair, prismatic pair, and universal pair) parallel walking mechanism is manufactured in terms of the optimized architecture parameters.
An Integrated Target Acquisition Approach and Graphical User Interface Tool for Parallel Manipulator Assembly
Authors: Chen Haodong , Teng Zhiqiang , Guo Zheng , Zhao Ping 
Published: November 2019

Abstract
In this paper, two integrated target identification and acquisition algorithms and a graphical user interface (GUI) simulation tool for automated assembly of parallel manipulators are proposed. They seek to identify the target machine part from the workspace, obtain its location and pose parameters, and accomplish its assembling task while avoiding the collision with other items (obstacles). Fourier descriptors (FDs) and support vector machine (SVM) are adopted in this approach. The image of task area of workspace is obtained through machine vision, and the target assembling parts are identified. To acquire the location and pose information of the target, a modulus-shift matching (MSM) algorithm is proposed and integrated into the FD and SVM approaches, which could efficiently obtain the pose parameters while eliminating the effect of choice of starting point. The simulation results of two integrated algorithms, FD-MSM and SVM-MSM, are then compared and analyzed. In addition, a GUI is designed to visualize and assist the assembly process. An application on delta parallel robot with an extra rotational degree of freedom (DOF) is presented.
Formation Mechanisms of Exit-Chippings in Rotary Ultrasonic Drilling and Conventional Drilling of Glass BK7
Authors: Lv Dongxi , Liu Dong , Chen Gang , Song Leilei , Yan Chun , Wu Xiaofei , Zhu Yingdan 
Published: November 2019

Abstract
This paper presented a fundamental investigation on the exit-chipping formation mechanisms involved in rotary ultrasonic drilling (RUD) and conventional drilling (CD) of glass BK7. It was found that the mutual tool-material extrusion initially activated the subsurface crack with the maximum depth (incipient crack) at the margin of the machined surface, and its penetration of the undrilled thickness brought about the emergence of the exit-chipping at Region I. Subsequently, the opposite propagations of two ring-cracks along the circumferential direction of the drilled hole were conducive to the collapse of the machined cylinder, thus leading to the appearance of the exit-chipping at Region II. Ultrasonic superposition significantly decreased the actual undrilled thickness of the machined surface, while slightly increased the exit-chipping width. All the exit-chippings, generated with and without ultrasonic, exhibited the elliptic and symmetrical morphologies accompanied by the corrugated stripes winding the entire chipping surfaces. The quantitative relationship between the instantaneous extrusion pressure and the propagation direction of the incipient crack was proposed, revealing that the propagation angle was inversely proportional to the extrusion pressure. Ultrasonic superimposition augmented the extrusion pressure exerted the machined surface, which reduced the propagation angle of the incipient crack. The elliptic morphology characteristics of the exit-chipping were attributed to the parabolic variation of the additional bending moment with the circumferential spreading of the ring-crack. Ultrasonic superposition increased the propagation angle of the ring-crack, thus deteriorating the exit quality of the drilled hole.
Dynamic Characteristics Analysis and Finite Element Simulation of Steel–BFPC Machine Tool Joint Surface
Authors: Shen Jiaxing , Xu Ping , Yu Yinghua 
Published: November 2019

Abstract
The dynamic performance of the steel–Basalt fiber polymer concrete (BFPC) machine tool joint surface (referred to as the joint surface) has a significant impact on the overall BFPC machine tool performance; however, its dynamic characteristics remain unclear. In order to solve this problem, the influence of roughness and surface pressure on the dynamic performance of joint surface was studied experimentally, and a neural network prediction model for the dynamic performance of the joint surface was established. A BFPC bed was designed and manufactured, and BFPC bed’s dynamic performance was tested experimentally. The finite element simulation model of BFPC bed was established with equivalent spring-damper element. The BFPC bed’s dynamic performance without considering the influence of the joint surface and considering the influence of the joint surface was studied separately. The results show that the maximum error of the natural frequency of the BFPC bed was 6.937% considering the influence of the joint surface, which was much lower than the error without considering the influence of the joint surface. The maximum amplitude error of the X-axis and Z-axis acceleration of the BFPC bed was 6.917% and 5.15%, which were much smaller than the error without considering the influence of the joint surface. It proves the accuracy of the neural network prediction model for dynamic performance of the joint surface and the validity of the finite element simulation method for the joint surface. It provides theoretical support for the design analysis of BFPC machine tool.
Effects of Varying Dynamics of Flexible Workpieces in Milling Operations
Authors: Kiss Adam K. , Bachrathy Daniel , Stepan Gabor 
Published: November 2019

Abstract
In this study, surface error calculations and stability conditions are presented for milling operations in case of slender parts. The dynamic behavior of the flexible beam-type workpiece is modeled by means of finite element method (FEM), while the varying dynamical properties related to the feed motion as well as the material removal process are incorporated in the model. The FEM-generated direct frequency response function is verified through a closed-form solution based on the distributed transfer function method. Relative errors and convergence of the FEM are investigated based on the analytical solutions of the continuum model, from which appropriate element size and mode number can be selected for modal coordinate transformations. The pattern in the variation of the natural frequencies is explored using the analytical model in case of high radial depth of cut relative to the original cross section of the beam-like workpiece. Both the stability conditions and the resulted surface errors are predicted as a function of the tool position. The presented approach and the results are validated by laboratory tests.