Hepatoprotective Activities of Colocasia esculenta (L.) Schottin Mice Model with Liver Injury Induced by Paracetamol
Authors: Quang Huy Nguyen , Quy Thuong Le , Xuan Huy Hoang , Quoc Hung Tran , Thi Mai Huong Phan , Quoc Viet Tran , Thi Phuong Hoa Le 
Published: September 2020

This paper uses the model of experimental mouse liver damage with paracetamol to evaluate the liver protective effects of the methanol extract (Colocasia esculenta (L.) Schott) (MCE). After 8 days, the hepatoprotective activities of MCE in mice (damaged by paracetamol) at doses of 500, 1,000 and 2,000 mg/kg/day proved effective as the AST enzyme content decreased by 6.98, 22.84 and 26.59%, respectively; and ALT decreased by 53.17, 56.46 and 57.93%, respectively. MCE at a dose of 1,000 mg/kg/day had a protective effect equivalent to that of silymarin (used in liver treatment) at a dose of 50 mg/kg/day and MCE at a dose of 2,000 mg/kg/day had better effect. Observation of the microscopic liver tissue cross section also revealed that the mice treated with MCE of C. esculenta at doses of 1,000 and 2,000 mg/kg/day showed significantly improvement in their liver tissues compared to the non-treated control group.
Keywords:
Colocasia esculenta, hepatoprotective, paracetamol.
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