bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detailed Design Optimization of Three-Fluid Parallel-Flow Plate-Fin Heat Exchanger Using Second Law Analysis
Authors: Aasi Harpreet Kaur , Mishra Manish 
Published: May 2020

Abstract
Compact parallel-flow three-fluid heat exchanger (TFHX) of plate-fin type is optimized for attaining the minimum entropy generation unit. Four different types of plate-fins (plain rectangular, offset strip, corrugated louvered, and wavy fin (WF)) which are embodied within heat exchanger have been selected for the study under both cocurrent and countercurrent flow arrangements. The range of the decision variables are 0.3≤ma, mb, mc≤3, 0.1≤Ø≤0.95, 0.1≤Lx, Ly≤2, 0.015≤H≤0.033, 100≤n≤700, 0.0001≤tf≤0.0002, 0.001≤l≤0.009, 0.01≤Lwav≤0.09, and 0.001≤A≤0.005. Genetic algorithm is selected as an optimization tool that is apt in handling various continuous and discrete variables and the problems with the complexities in the objective function as well as in constraints. Validation of the optimization model is carried out by comparing the optimum results with that obtained from the experiments, particle swarm optimization (PSO) (under without heat duty constraint), and graphical method (under with heat duty constraint). It is observed that for a specified heat duty (180 kW) and given operating conditions, corrugated louvered fin (CLF) with countercurrent flow arrangement offers the minimum entropy generation among all. It is riveting to learn that the optimum results occur for most of the considered cases when the flowrate of the central hot fluid is lower than that of the adjacent fluids. At fixed Re = 3000 for all the fin types, off-set strip fin is the most favorable one, and plain rectangular fin (PRF) offers the worst solution comparatively.
Nonhyperbolicity of Conservation Equations of RELAP5 Two-Fluid Model in Nuclear Reactor Safety Results (Investigation and Eigenvalue Analysis)
Authors: Saraswat S. P. , Munshi P. , Allison C. 
Published: May 2020

Abstract
The RELAP5 code simulates the thermal-hydraulic characteristics of nuclear reactors by the use of a two-fluid one-dimensional, nonequilibrium, nonhomogeneous two-phase flow model. This model consists of six governing equations to describe the mass, energy, and momentum of the two fluids. The scope of this work comprises the study of the mathematical nature of the code model and to predict the accuracy of the model in the nuclear reactor safety analysis. The method of characteristics (MOC) is applied to check the nonhyperbolic nature of conservation equations for all normal and accident conditions of light water reactors (LWRs). The analysis also gives information about the soundness of the model and to identify the regions where the solutions obtained from it will be numerically convergent. The characteristics of equations of nonhyperbolic nature are complex. It implies that results thus obtained (by finite difference method) have to be interpreted very carefully in view of the sensitive nature of reactor safety analysis. The present analysis shows that governing equations of the code exhibit complex characteristics for some operating conditions thus implying nonhyperbolicity under those conditions. Results are less accurate under such conditions, so sensitivity analysis plays an important role. The sensitivity of closure relationship on the conservation equation's stability is also checked. The analysis is performed in matlab environment for three different systems, (a) pressurized water reactor (PWR), boiling water reactor (BWR), and (c) natural circulation reactor or advance heavy water reactor (AHWR). These results can also be extended to other thermal-hydraulic systems. The different values of the coefficient of closure relationship are taken for different flow regimes. It is observed that the coefficient of virtual mass (for momentum equation) has a significant effect on the hyperbolicity of the system. It is recommended that further development of the RELAP5 model be performed to identify changes that would reduce the region of complex characteristics. The importance of MOC (in nuclear reactor thermal-hydraulic safety analysis) is evident here. In addition, a detailed analysis for operating pressures range of 0.1–22.5 MPa is also performed to find out the nonhyperbolic regions of code model and realistic data of the different type of reactors is used as input of the code. It is also observed here that RELAP5 results are less accurate when system pressure exceeds 19.5 MPa.
Comparison of a new versus standard removable offloading device in patients with neuropathic diabetic foot ulcers: a French national, multicentre, open-label randomized, controlled trial
Authors: Potier Louis , François Maud , Dardari Dured , Feron Marilyne , Belhatem Narimene , Nobecourt-Dupuy Estelle , Dolz Manuel , Bordier Lyse , Ducloux Roxane , Chibani Abdelkader , Eveno Dominique-François , Crea Avila Teresa , Sultan Ariane , Baillet-Blanco Laurence , Rigalleau Vincent , Gand Elise , Saulnier Pierre-Jean , Velho Gilberto , Roussel Ronan , Pellenc Quentin , Dupré Jean-Claude , Malgrange Dominique , Marre Michel , Mohammedi Kamel 
Published: May 2020

IntroductionThe offloading is crucial to heal neuropathic diabetic foot ulcer (DFU). Removable offloading are the most used devices.Orthèse diabèteis a new customized removable knee-high offloading device immobilizing foot and ankle joints, with some specific and innovative features that may improve offloading. We aimed to evaluate the efficiency ofthis devicein DFU healing.Research, design and methodsThe evaluation of Offloading using a new removable ORTHOsis in DIABetic foot study is a French multicenter (13 centers) randomized controlled trial with blinded end points evaluation. Adults with neuropathic DFU were randomly assigned to eitherOrthèse Diabète (experimental device), or any type of conventional (usually used in France) removable offloading devices (control group). The primary outcome was the 3-month proportion of patients with fully healed DFU.ResultsAmong 112 randomized patients (men 78%, age 62±10 years), the primary outcome occurred in 19 (33%) participants using conventional device vs 19 (35%)Orthèse Diabèteusers (p=0.79). Study groups were also comparable in terms of prespecified secondary end points including occurrence of new DFU (25% vs 27% in conventional and experimental groups), ipsilateral lower-limb amputation (4% vs 10%) or infectious complications (14% vs 13%) (p>0.05 for all). Adverse events were comparable between groups, including 4 deaths unrelated to study allocation (1 sudden death, 2 ventricular arrhythmias and 1 pancreatic cancer). Adverse events believed to be related to the device were higher in theOrthèse Diabètegroup than in the control group (15% vs 4%).Orthèse Diabètewas less frequently worn than conventional devices (46% vs 66%, p=0.04).ConclusionsOrthèse Diabète, a new removable offloading orthosis immobilizing foot and ankle joints did not show superiority compared with conventional removable devices in neuropathic DFU healing and cannot be recommended to heal DFU.Trial registration numberNCT01956162.
Validation of a simplified score for predicting latent rheumatic heart disease progression using a prospective cohort of Brazilian schoolchildren
Authors: Bechtlufft Bárbara Martins , Nascimento Bruno Ramos , Sable Craig , Fraga Clara Leal , Barbosa Márcia Melo , Reis Susana Drumond , Diamantino Adriana Costa , Meira Zilda Maria Alves , Castilho Sandra Regina Tolentino , Arantes Nayana Flamini , Oliveira Kaciane Krauss , Silva José Luiz Padilha , Rezende Breno De Filippo , Costa Waydder Antônio Aurélio , Mata Mariana Duarte , Pereira Augusto Ferreira , Ribeiro Antonio Luiz Pinho , Beaton Andrea Zawacki , Pereira Nunes Maria Carmo 
Published: May 2020

ObjectivesEchocardiographic (echo) screening is an important tool to estimate rheumatic heart disease (RHD) prevalence, but the natural history of screen-detected RHD remains unclear. The PROVAR+ (Programa de RastreamentO da VAlvopatia Reumática) study, which uses non-experts, telemedicine and portable echo, pioneered RHD screening in Brazil. We aimed to assess the mid-term evolution of Brazilian schoolchildren (5–18 years) with echocardiography-detected subclinical RHD and to assess the performance of a simplified score consisting of five components of the World Heart Federation criteria, as a predictor of unfavourable echo outcomes.SettingPublic schools of underserved areas and private schools in Minas Gerais, southeast Brazil.ParticipantsA total of 197 patients (170 borderline and 27 definite RHD) with follow-up of 29±9 months were included. Median age was 14 (12–16) years, and 130 (66%) were woman. Only four patients in the definite group were regularly receiving penicillin.Primary and secondary outcome measuresUnfavourable outcome was based on the 2-year follow-up echo, defined as worsening diagnostic category, remaining with mild definite RHD or development/worsening of valve regurgitation/stenosis.ResultsAmong patients with borderline RHD, 29 (17.1%) progressed to definite, 49 (28.8%) remained stable, 86 (50.6%) regressed to normal and 6 (3.5%) were reclassified as other heart diseases. Among those with definite RHD, 13 (48.1%) remained in the category, while 5 (18.5%) regressed to borderline, 5 (18.5%) regressed to normal and 4 (14.8%) were reclassified as other heart diseases. The simplified echo score was a significant predictor of RHD unfavourable outcome (HR 1.197, 95% CI 1.098 to 1.305, p<0.001).ConclusionThe simple risk score provided an accurate prediction of RHD status at 2-year follow-up, showing a good performance in Brazilian schoolchildren, with a potential value for risk stratification and monitoring of echocardiography-detected RHD.
Psychological concerns of Indian women with breast cancer in different national contexts: a systematic review and mixed-methods synthesis
Authors: Daniel Sunitha , Clark Joseph , Gnanapragasam Sam , Venkateswaran Chitra , Johnson Miriam J 
Published: May 2020

BackgroundBreast cancer is becoming the most common cancer among women of Indian origin. However, little is known about the psychological impact of the disease and its treatment among this population.AimTo improve understanding of psychological symptoms among Indian women with breast cancer.DesignThis is a systematic literature review and critical interpretive synthesis. Medical Subject Headings(MeSH) terms and keywords for breast cancer, psychological symptoms and treatment were used to search databases from inception to 7 May 2019. The reference lists of the included articles were examined. Search results were screened against the inclusion criteria, data were extracted, and quality was appraised by two independent researchers with recourse to a third. Narrative (quantitative) and thematic qualitative syntheses were applied, followed by critical interpretive synthesis.Data sourcesProQuest, MEDLINE, Ovid EMBASE, EBSCO, Cumulative Index to Nursing and Allied Health Literature, and PsycINFO.Results18 of 763 studies from India or Canada were included (13 quantitative, 5 qualitative). Critical interpretive synthesis found psychological concerns similar to ‘Western’ women, but were framed by the common culture of Indian women in either country. Family structure, religion and community appear to protect against and cause distress in relation to the expected core role of being a wife and a mother and the male dominance in decision making. Stigma was amplified by poor knowledge about the nature of cancer. Migrant Indian women had additional problems due to language barriers.ConclusionsIndian women with breast cancer living in India and Canada experience psychological morbidities which profoundly affect their role in their family and the wider community. Culturally congruent care, including accessible communication and information, may help prevent and alleviate distressing symptoms whether in India or in a migrant community.
The impact of an integrated heart failure service in a medium-sized district general hospital
Authors: Hawley Alasdair , He Jingzhou , Crabtree Alice , Iacovides Stelios , Keeling Phil 
Published: May 2020

ObjectivesAssessing the impact of a new integrated heart failure service (IHFS) in a medium-sized district general hospital (DGH) on heart failure (HF) mortality, readmission rates, and provision of HF care.MethodsA retrospective, observational study encompassing all patients admitted with a diagnosis of HF over two 12-month periods before (2012/2013), and after (2015/2016) IHFS establishment.ResultsTotal admissions for HF increased by 40% (385 vs 540), with a greater number admitted to the cardiology ward (231 vs 121). After IHFS implementation, patients were more likely to see a cardiologist (35.1% vs 43.7%, p=0.009), undergo echocardiography (70.1% vs 81.5%, p<0.001), be initiated on all three disease modifying HF medications (angiotensin-converting enzyme inhibitors (ACEi), angiotensin II receptor blockers (ARB) and mineralocorticoid receptor antagonists (MRA)) in the heart failure with reduced ejection fraction (HFrEF) group (42% vs 99%, p<0.001) and receive specialist HF input (81.6% vs 85.4%, p=0.2). Both 30-day post-discharge mortality and HF related readmissions were significantly lower in patients with heart failure with preserved ejection fraction (HFpEF) (8.9% vs 3.1%, p=0.032, 58% reduction, p=0.043 respectively) with no-significant reductions in all other HF groups. In-patient mortality was similar. Length of stay in Cardiology wards increased from 8.4 to 12.7 days (p<0.001).ConclusionEstablishment of an IHFS within a DGH with limited resources and only a modest service re-design has resulted in significantly improved provision of specialist in-patient care, use of HFrEF medications, early heart failure nurse follow-up, and is associated with a reduction in early mortality, particularly in the HFpEF cohort, and HF related readmissions.
DMARD-free remission as novel treatment target in rheumatoid arthritis: A systematic literature review of achievability and sustainability
Authors: Verstappen M , van Mulligen E , de Jong P H P , van der Helm-Van Mil A H M 
Published: May 2020

ObjectivesAlthough current treatment guidelines for rheumatoid arthritis (RA) suggest tapering disease-modifying anti-rheumatic drugs (DMARDs), it is unclear whether DMARD-free remission (DFR) is an achievable and sustainable outcome. Therefore, we systematically reviewed the literature to determine the prevalence and sustainability of DFR and evaluated potential predictors for DFR.MethodsA systematic literature search was performed in March 2019 in multiple databases. All clinical trials and observational studies reporting on discontinuation of DMARDs in RA patients in remission were included. Our quality assessment included a general assessment and assessment of the description of DFR. Prevalence of DFR and its sustainability and flares during tapering and after DMARD stop were summarised. Also, potential predictors for achieving DFR were reviewed.ResultsFrom 631 articles, 51 were included, comprising 14 clinical trials and 5 observational studies. DFR definition differed, especially for the duration of DMARD-free state. Considering only high- and moderate-quality studies, DFR was achieved in 5.0%–24.3% and sustained DFR (duration>12 months) in 11.6%–19.4% (both relative to the number of patients eligible for tapering). Flares occurred frequently during DMARD tapering (41.8%–75.0%) and in the first year after achieving DFR (10.4%–11.8%), while late flares, >1 year after DMARD-stop, were infrequent (0.3%–3.5%). Many patient characteristics lacked association with DFR. Absence of autoantibodies and shared epitope alleles increased the chance of achieving DFR.ConclusionsDFR is achievable in RA and is sustainable in ~10%–20% of patients. DFR can become an important outcome measure for clinical trials and requires consistency in the definition. Considering the high rate of flares in the first year after DMARD stop, a DMARD-free follow-up of >12 months is advisable to evaluate sustainability.
High prevalence of coinfection of azithromycin-resistantMycoplasma genitaliumwith other STIs: a prospective observational study of London-based symptomatic and STI-contact clinic attendees
Authors: Broad Claire E , Furegato Martina , Harrison Mark A , Pond Marcus J , Tan NgeeKeong , Okala Sandra , Fuller Sebastian S , Harding-Esch Emma M , Sadiq S Tariq 
Published: May 2020

ObjectivesAzithromycin treatment ofChlamydia trachomatis(CT) may not be adequate to treat concomitantMycoplasma genitalium(MG) infection, and particularly if MG has macrolide resistance-associated mutations (MG-MRAMs). We estimated prevalence of coinfections of CT with MG carrying MRAM, and risk factors for MG-MRAM among a sexual health clinic population.Study design and settingAmong symptomatic and STI-contact clinic attendees in London, prevalence of CT-MG coinfection and MG-MRAM were estimated using nucleic acid amplification testing and Sanger sequencing, respectively, and their associated risk factors analysed using logistic regression.ResultsMG prevalence was 7.5% (23/307), 17.3% (30/173), and 11.4% (8/70) in females, men who have sex with women (MSW) and men who have sex with men (MSM), respectively; MG coinfection in CT-infected participants represented 28.0% (7/25), 13.5% (5/37), 0.0% (0/0), respectively. Presence of MG-MRAM was 39.1% (9/23) in female swabs, 70.0% (21/30) in MSW urine and 83.3% (5/6) in MSM rectal swabs. In multivariate analyses, coinfection with another STI was strongly associated with MG-MRAM (OR: 7.19; 95% CI: 2.4 to 21.5).ConclusionA significant proportion of participants in our study of symptomatic patients and STI contacts were infected with macrolide-resistant MG, suggesting that testing for MG and MRAM, for MG positives, might be clinically useful. The findings also suggest services explore potential benefits of testing CT positive samples for MG in these patient groups. Where MG testing is not available, potential high rates of MG coinfection should be borne in mind when considering azithromycin in the treatment of CT among STI contacts and symptomatic patients.
Einstein clusters as models of inhomogeneous spacetimes
Authors: Szybka Sebastian J. , Rutkowski Mieszko 
Published: May 2020

AbstractWe study the effect of small-scale inhomogeneities for Einstein clusters. We construct a spherically symmetric static spacetime with small-scale radial inhomogeneities and propose the Gedankenexperiment. An hypothetical observer at the center constructs, using limited observational knowledge, a simplified homogeneous model of the configuration. An idealization introduces side effects. The inhomogeneous spacetime and the effective homogeneous spacetime are given by simple solutions to Einstein equations. They provide a basic toy-model for studies of the effect of small-scale inhomogeneities in general relativity. We show that within our highly inhomogeneous model the effect of small-scale inhomogeneities remains small for a central observer. The homogeneous model fits very well to all hypothetical observations as long as their precision is not high enough to reveal a tension.
Towards a heavy diquark effective theory for weak decays of doubly heavy baryons
Authors: Shi Yu-Ji , Wang Wei , Zhao Zhen-Xing , Meißner Ulf-G. 
Published: May 2020

AbstractWe construct a leading-order effective field theory for both scalar and axial-vector heavy diquarks, and consider its power expansion in the heavy diquark limit. By assuming the transition from QCD to diquark effective theory, we derive the most general form for the effective diquark transition currents based on the heavy diquark symmetry. The short-distance coefficients between QCD and heavy diquark effective field theory are also obtained by a tree level matching. With the effective currents in the heavy diquark limit, we perform a reduction of the form factors for semi-leptonic decays of doubly heavy baryons, and find that only one nonperturbative function is remaining. It is shown that this soft function can be related to the Isgur–Wise function in heavy meson transitions. As a phenomenological application, we take a single pole structure for the reduced form factor, and use it to calculate the semi-leptonic decay widths of doubly heavy baryons. The obtained results are consistent with others given in the literature, and can be tested in the future.
Magneto-vortical effect in strongly coupled plasma
Authors: Bu Yanyan , Lin Shu 
Published: May 2020

AbstractBased on a holographic model incorporating both the chiral anomaly and the gravitational anomaly, we study the effect of magneto-vortical coupling on the transport properties of a strongly coupled plasma. The focus of present work is on the generation of a vector charge density and an axial current, as response to vorticity in a magnetized plasma. The transport coefficients parameterizing the vector charge density and axial current are calculated both analytically (in the weak magnetic field limit) and also numerically (for general values of the magnetic field). We find the generation of vector charge receives both non-anomalous and anomalous contributions, with the non-anomalous contribution dominating in the limit of a strong magnetic field and the anomalous contribution sensitive to both chiral anomaly and gravitational anomaly. On the contrary, we find the axial current is induced entirely due to the gravitational anomaly, thus we interpret the axial current generation as chiral vortical effect. The corresponding chiral vortical conductivity is found to be suppressed by the magnetic field. By the Onsager relation, these transport coefficients are responsible for the generation of a thermal current due to a transverse electric field or a transverse axial magnetic field, which we call the thermal Hall effect and the thermal axial magnetic effect, respectively.
A first proof of principle booster setup for the MADMAX dielectric haloscope
Authors: Egge Jacob , Knirck Stefan , Majorovits Béla , Moore Christopher , Reimann Olaf 
Published: May 2020

AbstractAxions and axion-like particles are excellent low-mass dark matter candidates. The MADMAX experiment aims to directly detect galactic axions with masses between 40 and $$400\,\upmu \mathrm{eV}$$400μeV by using the axion-induced emission of electromagnetic waves from boundaries between materials of different dielectric constants under a strong magnetic field. Combining many such surfaces, this emission can be significantly enhanced (boosted) using constructive interference and resonances. We present a first proof of principle realization of such a booster system consisting of a copper mirror and up to five sapphire disks. The electromagnetic response of the system is investigated by reflectivity measurements. The mechanical accuracy, calibration process of unwanted reflections and the repeatability of a basic tuning algorithm to place the disks are investigated. We find that for the presented cases the electromagnetic response in terms of the group delay predicted by one-dimensional calculations is sufficiently realized in our setup. The repeatability of the tuning is at the percent level, and would have small impact on the sensitivity of such a booster.