bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discovering the sustainable hotel brand personality on TripAdvisor
Authors: Paiva Neto Aureo , Lopes da Silva Elaine Aparecida , Ferreira Lissa Valéria Fernandes , Araújo José Felipe Ribeiro 
Published: July 2020

Purpose
This paper aims to explore a hotel brand personality performance through electronic word-of-mouth. A complementary attribute is designed and tested in addition to the already existing five dimensions from the brand personality scale, denominated sustainability.

Design/methodology/approach
A sample of 16,175 reviews from the rating session of three hotel properties behind a brand was retrieved from TripAdvisor for a data mining procedure. A complementary list of associated words was considered in addition to the 42 personality traits of Aaker’s model, and a brief inventory was developed based on the 17 sustainable development goals (SDGs) to compose the sustainability dimension.

Findings
This study registered sincerity as the most representative dimension in its results, and ruggedness as the lowest. This is evidence that the latter is not suitable for representing a brand personality scale for hotels and could be replaced by sustainability.

Research limitations/implications
Despite the relevant findings, new surveys and tests are recommended to provide better support to the new proposed dimension.

Practical implications
This investigation enables hotel managers to work more effectively on their brand strategies based on sustainability-oriented brand personality, which could deliver economic, social and environmental benefits to the world by influencing consumption behavior in association with the SDGs.

Originality/value
This study differs from existing literature by attempting to fill a gap on the limitations of studies focused on linking brand personality to sustainability, and using data mining to reach this goal.
Sustainable development of the business environment in smart cities: a hierarchical framework
Authors: Jiang Mingnan , Gao Yang , Jin Mingwei , Liu Sitong 
Published: July 2020

Purpose
The purpose of this study is to explore a sustainable hierarchical framework for the business environment in smart cities. However, this hierarchical framework must consider unnecessary attributes and interrelationships between criteria to capture the difference between smart cities and traditional cities.

Design/methodology/approach
Hence, the fuzzy set theory is used for screening unnecessary attributes, the decision-making and trial evaluation laboratory (DEMATEL) is applied to manage the complex interrelationships among the aspects and attributes and interpretive structural modeling (ISM) is used to divide the hierarchy and construct a hierarchical theoretical framework. Ultimately, this research is applied to develop a sustainable hierarchical framework of the business environment in smart cities.

Findings
The results show that traditional social problems are still at the core of business environment development in smart cities, new smart opportunities may be discovered, but they are still limited by traditional social factors, the economy is still the main aspect of the business environment and there are still obstacles to solving social problems with smart technologies.

Originality/value
This theoretical hierarchical framework aims to guide smart cities toward sustainability. This study also proposes creating a predictable business environment by improving administrative efficiency, transparency, social mobility and infrastructure services and cultivating new business opportunities with intelligent technology.
Research watch: Coronavirus (COVID-19), mental health and social inclusion in the UK and Ireland
Authors: Holttum Sue 
Published: July 2020

Purpose
This paper aims to examine recent papers on the effects of the COVID-19 pandemic on mental health, including implications for some of the groups of people already less included in society.

Design/methodology/approach
A search was carried out for recent papers on mental health and the COVID-19 pandemic.

Findings
Two papers describe surveys of adults in the UK and Irish Republic in the first days of lockdown. Low income and loss of income were associated with anxiety and depression. These surveys could not examine distress in Black and minority ethnicities, who have higher death rates from COVID-19. Two surveys of children and young people report distress and what can help. One paper summarises a host of ways in which the pandemic may affect mental well-being in different groups, and what might help. Another calls for research to understand how to protect mental well-being in various groups.

Originality/value
These five papers give a sense of the early days of the pandemic, especially in the UK. They also highlight the needs of some specific groups of people, or the need to find out more about how these groups experience the pandemic. They suggest some ways of trying to ensure that everyone has the best chance to thrive in the aftermath of the pandemic.
Unsettling Knowledge: Irony and Education
Authors: Smith Richard 
Published: July 2020

Abstract
Philosophy is sometimes thought of as having two principal dimensions: one that aims to build systems and doctrines, and another that is concerned to unsettle fixed ways of thinking. Richard Peters seems to position himself in both camps. I suggest that education in the UK today increasingly bears the marks of rigid thinking, largely as a result of the domination of neoliberal fundamentalism, and is in particular need of unsettling. This, I argue, was a major part of western philosophy's mission at what we think of as its birth in the work of Socrates and Plato's dialogues. In these texts too we see depicted the arrogance and complacency of characters who may sometimes remind us of our contemporaries. The Socratic irony that is evident everywhere in the dialogues is their undoing.
Prenatal visualisation of the torcular herophili by means of a Doppler technology highly sensitive for low‐velocity flow in the expert assessment of the posterior fossa: a prospective study
Authors: Dall'Asta A , Grisolia G , Volpe N , Schera GBL , Sorrentino F , Frusca T , Ghi T 
Published: July 2020

ObjectiveTo evaluate the usefulness of a Doppler technology highly sensitive for low‐velocity flow in the antenatal imaging of the torcular herophili (TH) in the second trimester of pregnancy.DesignProspective study.SettingReferral Fetal Medicine Unit.PopulationNon‐consecutive series of singleton pregnancies submitted to antenatal neurosonogram between 20 and 28 weeks of gestation.MethodsA midsagittal section of the fetal brain was obtained by insonating through the anterior fontanelle, then the MV‐Flow™ and LumiFlow™ presets were selected to visualise the TH as the posterior confluence of the superior sagittal sinus and the straight sinus.Main outcome measuresEvaluation of the anatomic relationship of the TH with the ‘transpalatal line’ joining the upper bony palate to the fetal skull.ResultsA total of 99 pregnant women were recruited, including one fetus with open spina bifida, one with Dandy–Walker malformation (DWM) and two with Blake's pouch cysts. In normal fetuses, the TH appeared to lie on or just below the ‘transpalatal line’. In the cases of Blake's pouch cyst, the position of the TH appeared normal if compared with controls, whereas in DWM a supra‐elevated position of the TH in respect of the transpalatal line was demonstrated. Finally, in the fetus with Chiari II malformation the TH was identified below the ‘transpalatal plane’.ConclusionsPrenatal ultrasound visualisation of the TH by means of newly developed Doppler technologies characterised by high sensitivity for low‐velocity flow is feasible and allows the indirect evaluation of the insertion of cerebellar tentorium in the second trimester.Tweetable abstractPrenatal imaging of the torcular herophili using a Doppler technology highly sensitive for low‐velocity flow.
Holistic vision of the patient with chronic kidney disease in a universalistic healthcare system
Authors: Clementi Anna , Coppolino Giuseppe , Provenzano Michele , Granata Antonio , Battaglia Giovanni Giorgio 
Published: July 2020

AbstractChronic kidney disease (CKD) is an increasing public health problem. Aging is one of the leading causes, particularly in Western countries, but several comorbidities, such as hypertension and diabetes are involved in its pathogenesis. Thus, the treatment of CKD patient is very complex and requires an integrated strategy. In this context, the holistic approach to the CKD patient and not to the disease itself should be the answer. General practitioners, specialists, voluntary associations, and nonprofit organizations, in addition to the family of the patient, all contribute to the patient care. Moreover, due to the low sensitivity of creatinine values in the early stages of renal failure, its diagnosis often occurs in the advanced phases of the disease. Therefore, the health costs for CKD patients are hardly sustainable by health systems. The reorganization of economic and epidemiological data through new models is necessary to allow the sustainability of the system and to ensure medical care for all patients. In this review, we aim to deal with all the issues about patient care, standards of care, and the impact of chronicity from a global perspective in light of the current state of the Italian healthcare system.
Effects of forced taxonomic transitions on metabolic composition and function in microbial microcosms
Authors: Louca Stilianos , Rubin Ilan N. , Madilao Lufiani L. , Bohlmann Jörg , Doebeli Michael , Wegener Parfrey Laura 
Published: July 2020

SummarySurveys of microbial systems indicate that in many situations taxonomy and function may constitute largely independent (‘decoupled’) axes of variation. However, this decoupling is rarely explicitly tested experimentally, partly because it is hard to directly induce taxonomic variation without affecting functional composition. Here we experimentally evaluate this paradigm using microcosms resembling lake sediments and subjected to two different levels of salinity (0 and 19) and otherwise similar environmental conditions. We used DNA sequencing for taxonomic and functional profiling of bacteria and archaea and physicochemical measurements to monitor metabolic function, over 13 months. We found that the taxonomic composition of the saline systems gradually but strongly diverged from the fresh systems. In contrast, the metabolic composition (in terms of proportions of various genes) remained nearly identical across treatments and over time. Oxygen consumption rates and methane concentrations were substantially lower in the saline treatment, however, their similarity either increased (for oxygen) or did not change significantly (for methane) between the first and last sampling time, indicating that the lower metabolic activity in the saline treatments was directly and immediately caused by salinity rather than the gradual taxonomic divergence. Our experiment demonstrates that strong taxonomic shifts need not directly affect metabolic rates.
The impact of roller pump‐assisted cardiotomy suction unit on hemolysis
Authors: Jahren Silje Ekroll , Jenni Hansjoerg , Roesch Yannick , Arn Rafael , Tevaearai Hendrik , Obrist Dominik , Carrel Thierry , Erdoes Gabor 
Published: July 2020

AbstractHemolysis in cardiac surgery is often related to the contact of blood with air or artificial surfaces. Variations of negative pressure in the suction cannulas may represent an additional factor. Limited data exist on the contribution of a roller pump‐assisted (RPA) cardiotomy suction unit to hemolysis. Elevation of free hemoglobin (fHb) following air suction (AS) or suction tip occlusion (STO) events of a pump‐assisted cardiotomy suction unit was investigated in a mock circuit filled with blood from slaughtered domestic pigs. AS‐associated hemolysis was measured over 240 minutes with 2 minutes of AS occurring every 10 minutes. STO‐associated hemolysis was analyzed over 80‐minute periods: configuration 1 (c1) comprised a cycle of 20 minutes (min) occlusion and 60 minutes RPA flow (20/60 minutes); c2 comprised 20 cycles of 1/3 minutes; c3 comprised 40 cycles of 0.5/1.5 minutes; and c4 comprised 80 cycles of 0.25/0.75 minutes. The AS setup did not lead to significant hemolysis after 2 (P = .97), 3 (P = .40) or 4 (P = .11) hours. The STO setup showed the greatest hemolysis (ΔfHb of 30 mg/dL) in c1 after 20 minutes. ΔfHb was different in c1 from all other configurations at 20 minutes (P < .0001) and 80 minutes (P < .05). Ex vivo generation of large negative pressures by STO events is the main cause of cardiotomy suction‐associated hemolysis. The clinical relevance of this mechanism needs further investigations.
Effects of dietary phytol on tissue accumulation of phytanic acid and pristanic acid and on the tissue lipid profiles in mice
Authors: Nakanishi Tomonori , Kagamizono Kazuhiro , Yokoyama Sayaka , Suzuki Ryoji , Sakakibara Hiroyuki , Erickson Laurie , Kawahara Satoshi 
Published: July 2020

AbstractRecent in vitro evidence suggests that the phytol‐derived fatty acids, phytanic acid (PA) and pristanic acid (PrA), are components of animal products with the potential to cause both beneficial and harmful effects on human health. In this study, we investigated the in vivo tissue accumulation of PA and PrA and the changes in tissue lipid profiles, using mice fed a phytol‐containing diet. After 4 weeks of treatment with a diet containing 1.0% phytol, plasma, adipose tissue, liver, and brain were collected and their lipid profiles were biochemically and gas‐chromatographically determined. Dietary phytol caused PA and PrA accumulation in the adipose tissue and liver but not in the brain, and reduced plasma and liver triacylglycerol levels. Phytol intake also decreased the fatty acid concentrations in the adipose tissue, especially polyunsaturated fatty acids such as linoleic acid, but increased the concentrations of these fatty acids in the liver. However, dietary phytol had a low impact on the brain lipid profile. This study suggests that dietary phytol intake caused accumulation of PA and PrA and modified lipid profiles in the adipose tissue and liver, but that the brain is an insusceptible tissue to dietary phytol‐induced changes.
Coffin‐Siris syndrome with bilateral macular dysplasia caused by a novel exonic deletion in ARID1B
Authors: Fujita Takako , Ihara Yukiko , Hayashi Hitomi , Ishii Atsushi , Ideguchi Hiroshi , Inoue Takahito , Imaizumi Taichi , Yamamoto Toshiyuki , Hirose Shinichi 
Published: July 2020

AbstractCoffin‐Siris syndrome (CSS) is a congenital anomaly syndrome characterized by developmental delay, coarse facial features, and hypoplasia of the fifth digit's nail or phalanges. Herein, we report a case of the 8‐year‐old female patient who showed developmental delay associated with dysplasia in the macular and large toe area. Comprehensive genomic analysis showed no possible candidate variants, but the subsequent genomic copy number analysis revealed a novel exonic deletion in the coding region of AT‐rich interactive domain‐containing protein 1B (ARID1B), a gene responsible for CSS. Genomic copy number analysis can aid in diagnosing CSS by confirming undiagnosed exonic deletions in ARID1B. Furthermore, this is the first report of CSS associated with bilateral macular dysplasia.
Patch test results of the European baseline series among 1309 patients in Turkey between 2013 and 2019
Authors: Boyvat Ayse , Kalay Yildizhan Incilay 
Published: July 2020

AbstractBackgroundPrevalences of sensitivity to contact allergens change over time as a result of variations in allergen exposure.ObjectivesThe aim of the study was to describe trends in sensitisation to allergens of the European baseline series in Turkey between 2013 and 2019.MethodsThe patch test results of 1309 patients with suspected allergic contact dermatitis (ACD) were analysed retrospectively, and the prevalence of contact allergies to European baseline series allergens was compared with previous data (for 1998‐2005).ResultsA total of 534 (40.8%) patients exhibited one or more positive patch test reaction. The five most frequent allergens were nickel sulfate (19.6%), potassium dichromate (6.5%), cobalt chloride (6%), Myroxylon pereirae resin (5%), and p‐phenylenediamine (PPD; 3.7%). Statistically significant increases in the prevalence of sensitisation to methylchloroisothiazolinone/methylisothiazolinone (MCI/MI; P < .001), Myroxylon pereirae resin (P < .001), PPD (P = .008), and fragrance mix I (P = .036) were observed in the 2013 to 2019 period compared with the 1998 to 2005 period. Conversely, positive reactions to neomycin sulfate (P = .029), clioquinol (P = .031), and primin (P = .001) decreased significantly.ConclusionThis study provides a comprehensive profile of ACD in Turkey. The remarkable increase in the MI and MCI/MI contact allergy observed underlines the urgent need for regulatory measures to reduce exposure to MI and MCI/MI in Turkey.
Sotagliflozin added to optimized insulin therapy leads to HbA1c reduction without weight gain in adults with type 1 diabetes: A pooled analysis of inTandem1 and inTandem2
Authors: Rodbard Helena W. , Giaccari Andrea , Lajara Rosemarie , Stewart John , Strumph Paul S. , Oliveira Juliana , Lapuerta Pablo , Castro Rita 
Published: July 2020

AbstractAimTo evaluate whether the addition of sotagliflozin to optimized insulin significantly increases the proportion of adults with type 1 diabetes who achieve HbA1c goals without weight gain.Materials and methodsIn a patient‐level pooled analysis (n = 1575) of data from two phase 3, 52‐week clinical trials (inTandem1 and inTandem2), the change from baseline in HbA1c and weight as well as the proportion of participants achieving an HbA1c of less than 7% without weight gain were compared between groups treated with placebo, sotagliflozin 200 mg and sotagliflozin 400 mg.ResultsFrom a mean baseline HbA1c of 7.7%, mean HbA1c changes at week 24 were −0.36% (95% CI −0.44% to −0.29%) and −0.38% (−0.45% to −0.31%) with sotagliflozin 200 and 400 mg versus placebo (P = .001 for both), respectively, with sustained effects through week 52. Weight significantly decreased at weeks 24 and 52 in both sotagliflozin groups compared with placebo. At week 52, the proportion of patients who achieved an HbA1c of less than 7% without weight gain was 21.8% with sotagliflozin 200 mg, 26.1% with sotagliflozin 400 mg and 9.1% with placebo (P < .001). Other HbA1c, weight and safety composite variables showed similar significant trends.ConclusionWhen added to optimized insulin therapy, sotagliflozin improved glycaemic control and body weight and enabled more adults with type 1 diabetes to achieve HbA1c goals without weight gain over 52 weeks, although there was more diabetic ketoacidosis relative to placebo.
Temporal‐plus epilepsy in children: A connectomic analysis in magnetoencephalography
Authors: Martire Daniel J. , Wong Simeon , Workewych Adriana , Pang Elizabeth , Boutros Sarah , Smith Mary Lou , Ochi Ayako , Otsubo Hiroshi , Sharma Roy , Widjaja Elysa , Snead O. Carter , Donner Elizabeth , Ibrahim George M. 
Published: July 2020

AbstractObjectiveSeizure recurrence following surgery for temporal lobe (TL) epilepsy may be related to extratemporal epileptogenic foci, so‐called temporal‐plus (TL+) epilepsy. Here, we sought to leverage whole brain connectomic profiling in magnetoencephalography (MEG) to identify neural networks indicative of TL+ epilepsy in children.MethodsClinical and MEG data were analyzed for 121 children with TL and TL+ epilepsy spanning 20 years at the Hospital for Sick Children. Resting‐state connectomes were derived using the weighted phase lag index from neuromagnetic oscillations. Multidimensional associations between patient connectomes, TL versus TL+ epilepsy, seizure freedom, and clinical covariates were performed using a partial least squares (PLS) analysis. Bootstrap resampling statistics were performed to assess statistical significance.ResultsA single significant latent variable representing 66% of the variance in the data was identified with significant contributions from extent of epilepsy (TL vs TL+), duration of illness, and underlying etiology. This component was associated with significant bitemporal and frontotemporal connectivity in the theta, alpha, and beta bands. By extracting a brain score, representative of the observed connectivity profile, patients with TL epilepsy were dissociated from those with TL+, independent of their postoperative seizure outcome.SignificanceBy analyzing 121 connectomes derived from MEG data using a PLS approach, we find that connectomic profiling could dissociate TL from TL+ epilepsy. These findings may inform patient selection for resective procedures and guide decisions surrounding invasive monitoring.
Phenotypic suppression of acral peeling skin syndrome in a patient with autosomal recessive congenital ichthyosis
Authors: Mohamad Janan , Nanda Arti , Pavlovsky Mor , Peled Alon , Malchin Natalia , Malovitski Kiril , Pramanik Rashida , Weissglas‐Volkov Daphna , Shomron Noam , McGrath John , Sprecher Eli , Sarig Ofer 
Published: July 2020

AbstractAutosomal recessive congenital ichthyosis (ARCI) manifests with generalized scaling often associated with generalized erythema. Mutations in at least 13 different genes have been reported to cause ARCI. Acral peeling skin syndrome (APSS) is a rare autosomal recessive disorder manifesting with peeling over the distal limbs and dorsal surfaces of hands and feet. APSS is mostly due to mutations in TGM5, encoding transglutaminase 5. Both ARCI and APSS are fully penetrant genetic traits. Here, we describe a consanguineous family in which one patient with mild ARCI was found to carry a homozygous mutation in ALOXE3 (c.1238G > A; p.Gly413Asp). The patient was also found to carry a known pathogenic homozygous mutation in TGM5 (c.1335G > C; p.Lys445Asn) but did not display acral peeling skin. Her uncle carried the same homozygous mutation in TGM5 but carried the ALOXE3 mutation in a heterozygous state and showed clinical features typical of APSS. Taken collectively, these observations suggested that the ALOXE3 mutation suppresses the clinical expression of the TGM5 variant. We hypothesized that ALOXE3 deficiency may affect the expression of a protein capable of compensating for the lack of TGM5 expression. Downregulation of ALOXE3 in primary human keratinocytes resulted in increased levels of corneodesmosin, which plays a critical role in the maintenance of cell‐cell adhesion in the upper epidermal layers. Accordingly, ectopic corneodesmosin expression rescued the cell‐cell adhesion defect caused by TGM5 deficiency in keratinocytes as ascertained by the dispase dissociation assay. The present data thus provide evidence for phenotypic suppression in a human hereditary skin disorder.
Bone age estimation from carpal radiography images using deep learning
Authors: Ding Yih An , Mutz Filipe , Côco Klaus F. , Pinto Luiz A. , Komati Karin S. 
Published: July 2020

AbstractBone age estimation has been used in medicine to verify whether the bone structure development degree of a person corresponds to their chronological age. Such estimate is useful for prognosis about the development of children and adolescents, as well as for the diagnosis of endocrinological diseases. This work proposes a fully automated methodology for bone age estimation from carpal radiography images. The methodology comprises two steps, the preprocessing of the image and the classification using a convolutional neural network. The system accuracy for different types of preprocessing is evaluated. We compare the accuracy achieved using the full radiography image as input for the neural network and using only parts of the image corresponding to the Phalangeal region, the Epiphyseal region, and the concatenation of these parts with a crop around the wrist. Digital image processing techniques are employed to segment these regions. Experiments are performed using radiography images from the California University Database. The impact of using different pre‐trained neural networks for transfer learning is evaluated.