bluuebunny/crossref_metadata_2025_split huggingface dataset:
The presentation of recurrent odontogenic keratocysts of the mandible with an emphasis on the tooth‐bearing area: a systematic review and meta‐analysis
Authors: Slusarenko da Silva Y. , Stoelinga P.J.W. , Naclério‐Homem M.G. 
Published: September 2020

AbstractAimTo gain insight in the actual ratio of recurrent odontogenic keratocysts (OKCs) occurring in the tooth‐bearing area as compared to the posterior region of the mandible in order to come up with reliable data to base upon a rational treatment policy.Material and MethodsWe searched MEDLINE, Web of Science, Scopus, Cochrane Library and Google Scholar databases for studies reporting on the location of recurrent mandibular OKCs. Risk Difference with a confidence interval of 95% of having the lesion in the tooth‐bearing area versus the posterior region was the effect measure.Pvalue for the summary effect of <0.05 was considered statistically significant.ResultsThe 1411 records retrieved were reduced to 13 studies to be qualitative/quantitative assessed. The pooled values showed that the difference in the clinical risk of having recurrent OKCs in the posterior region of the mandible and in the tooth‐bearing area of the maxilla is of 7% (CI: −0.08, 0.22;P = 0.36), the posterior region being more susceptible to develop a recurrent OKC.ConclusionsThe recurrence rate of OKCs in the posterior mandible is not significantly higher than of those located in the tooth‐bearing part of the mandible; however, there is no reason to follow a more aggressive treatment policy for OKCs in the tooth‐bearing area.
Marker‐assisted introgression of QTLs for yield under moisture stress into elite varieties of rice (Oryza sativa)
Authors: Bhukya Jeevula N. , Bollineni Swarajyalakshmi N. , Kadambari Gopalakrishna , Bommisetty Reddiyamini , Gudikati Eswar R. , Darsha Withanawasam M. , Issa Keerthi , Akkareddy Srividhya , Eslavath Suresh N. , Dokuparthi Ajay K. , Eragam Aparna , Moode Vinodkumar N. , Pottepalem Rameshbabu , Chintala Srilakshmi , Narrareddy Eswarareddy P. , Tanti Bahbhen , Nimai Mandal P. , Muniraju Pallavi , Janaki Yeswanth V. , Vemireddy Lakshminarayana R. 
Published: September 2020

AbstractRice production is severely constrained by the moisture stress. The present study was undertaken to transfer two important QTLs viz., (qDTY2.2 and qDTY4.1), which controls yield under moisture stress (DTY) into two elite varieties, that is, MTU1010 and NLR34449 through marker‐assisted breeding. Foreground and background selections of backcross generations, that is, BC1F1, BC2F1 and BC2F2 identified several promising introgression lines (ILs) with two QTLs and single QTLs with an appreciable level of recovery of recipient parent genome. In ILs, the recovery of MTU1010 genome content was estimated to be 83%–93% while the recovery of NLR34449 was 84%–92%. The two‐QTL ILs of MTU1010 and NLR34449 backgrounds (qDTY2.2 and qDTY4.1) have shown substantial yield advantage (32 to 84%) over the single‐QTL ILs (either qDTY2.2 or qDTY4.1) under moisture stress conditions. Among all, two ILs, MBC‐124 and NBC‐127 are the best high yielding lines under moisture stress conditions. These outyielded ILs have the potential to be released as varieties in rainfed ecosystem and also can be used as donors in the existing breeding programme in rice.
Thermal and spatial data integration for recreating rebuilding stages of wooden and masonry buildings
Authors: Lewińska Paulina , Maciuk Kamil 
Published: September 2020

AbstractThis paper describes the means of supporting virtual reconstruction of wooden and masonry buildings with the use of thermal infrared images. Not all remaining architectural heritage can be physically preserved. War, climate change and rapidly growing cities have caused damage and degradation to valuable historical buildings. In order to preserve them virtually, various methods of 3D modelling have been employed. This paper presents information on how to create a full 3D inventory of a building’s exterior. This includes a 3D thermal model of the building, merging thermal camera data with a spatial model, which aids the reconstruction of previous stages of a building’s existence. The authors argue that in cases when it is impossible to force heat transfer from inside the structure (via man‐made heating), 24 hours of observations using only solar heating can be sufficient to find heat bridges and other thermal anomalies that can be used for virtual reconstruction.
Characteristics and long‐term survival of patients with chronic thromboembolic pulmonary hypertension in China
Authors: Deng Limin , Quan Ruilin , Yang Yuanhua , Yang Zhenwen , Tian Hongyan , Li Shengqing , Shen Jieyan , Ji Yingqun , Zhang Gangcheng , Zhang Caojin , Wang Guangyi , Liu Yuhao , Cheng Zhaozhong , Yu Zaixin , Song Zhiyuan , Zheng Zeqi , Cui Wei , Chen Yucheng , Liu Shuang , Xiong Changming , Shan Guangliang , He Jianguo 
Published: September 2020

This is the first multicentre prospective registry reporting baseline characteristics and estimated survival of patients with chronic thromboembolic pulmonary hypertension (CTEPH) in China. A total of 593 patients with CTEPH were included. The long‐term survival rates are similar to those of patients in the international and Spanish registries. Pulmonary endarterectomy is an independent predictor of survival.See related Editorial
Perinatal outcomes and central nervous system abnormalities following intrauterine fetal transfusion: 17 years' experience in a tertiary center
Authors: Sánchez‐Durán María Ángeles , Higueras María Teresa , Avilés‐García Mayte , Maiz Nerea , Rodríguez‐Aliberas Marta , Arévalo Silvia , Vázquez Elida , Ruiz Campillo César W. , Carreras Elena 
Published: September 2020

AbstractBackgroundThis study aimed to describe the perinatal outcome and central nervous system (CNS) anomalies in fetuses undergoing red blood cell (RBC) intrauterine transfusion (IUT).Methods and MaterialsThis was an observational single‐cohort study carried out at Vall d'Hebron University Hospital in Barcelona, Spain, between 2002 and 2018 in women undergoing RBC IUT for suspected fetal anemia. Primary outcomes were adverse perinatal outcome (intrauterine or neonatal death and termination of pregnancy [TOP]), prenatal or postnatal CNS anomalies, and significant neurological impairment.ResultsA total of 145 RBC transfusions were performed in 68 pregnancies of 60 women. The median gestational age for the first transfusion was 26 weeks (range, 18‐32). Twenty‐two (32%) fetuses were hydropic at the first transfusion. Fifty‐eight pregnancies (85.3%) resulted in live births and 10 (14.7%) in adverse perinatal outcomes. Adverse perinatal outcomes were associated with hydrops (odds ratio [OR], 6.69; 95% confidence interval [CI], 1.53‐29.23; P = .012) and gestational age at first transfusion (OR, 0.69; 95% CI, 0.54‐0.89; P = .04). Four (5.9%) cases of cerebellar hemorrhage were diagnosed prenatally. In 14 (35%) of the 41 neonates undergoing brain ultrasound and/or magnetic resonance imaging (MRI) abnormalities were reported. The median follow‐up was 6.5 years (range, 3 months to 19 years). Significant neurological impairment was reported in two cases (4.2%).ConclusionIn fetuses undergoing intrauterine RBC transfusion, the survival rate is high, particularly in the absence of hydrops and if the gestational age at first transfusion is above 22 weeks. Significant neurological impairment is uncommon, despite the fact that postnatal CNS anomalies at ultrasound or MRI are frequent.
Import exposure and welfare effects from the expenditure channel: The case of Mexico
Authors: Blyde Juan 
Published: September 2020

AbstractA rise in import competition can put downward pressure on local prices increasing consumer's welfare, but these gains might be unequal across households depending on the basket of goods consumed. Using a consumer price index that varies at the product and city level from Mexico, this paper analyses the impact of import competition from low‐wage countries, and particularly China, on price growth between 2002 and 2017. I find that the trade shock impacted prices. Had import competition remained unchanged, the 15‐year change in the consumer price index would have been seven percentage points higher, on average across all goods, with a much larger impact on the products highly exposed to the import competition. Second, using microdata from a household expenditure survey I find that all the households benefited from this access to cheaper goods, but the low‐income households benefited more. Finally, I show that the China shock only had a small effect on the evolution of the per capita expenditure inequality observed during this period.
The influence of the choice of preemptive analgesia on long‐term postsurgical pain after tibial plateau leveling osteotomy in dogs
Authors: Pownall William , Rytz Ulrich , Schuepbach Gertraud , Spadavecchia Claudia , Rohrbach Helene 
Published: September 2020

AbstractObjectiveTo evaluate the prevalence of chronic postsurgical pain (CPSP) after tibial plateau leveling osteotomy (TPLO) in dogs and to determine the influence of preemptive locoregional analgesia on CPSP.Study designRetrospective study.AnimalsOne hundred twenty client‐owned dogs.MethodsMedical records of dogs that underwent TPLO between 2012 and 2016 were reviewed for demographic information and type of preemptive analgesia. Owners were contacted to retrospectively assess the quality of life of their dogs by using the Helsinki Chronic Pain Index (HCPI) before and 6 months after surgery and at the time of questioning. An HCPI score > 12 was considered indicative of CPSP. Medical records were reviewed for demographic information and type of preemptive analgesia. A cumulative logit model was used to assess correlation of type of perioperative analgesia, HCPI, and demographic data.ResultsThe HCPI score was consistent with CPSP in 41 of 101 dogs with long‐term follow‐up (2.9 ± 1.5 years after surgery). Chronic postsurgical pain was documented in 11 of 32 and 13 of 28 dogs that received a spinal or epidural injection, respectively, or in 28 of 80 and 25 of 67 dogs with sciatic‐femoral block at 6 months or with long‐term follow‐up after TPLO, respectively (P > .05). A negative correlation was found between HCPI and both weight and age 6 months after surgery. Only weight remained negatively correlated 2.9 years after surgery.ConclusionForty‐one percent of dogs that were evaluated exhibited HCPI values compatible with CPSP long‐term after TPLO, regardless of the type of preemptive analgesia. Increased body weight was a negative prognostic factor for CPSP development.Clinical significance: Additional studies are required to evaluate CPSP development after TPLO.
Multilocus and morphological analysis of south‐eastern Iberian Wall lizards (Squamata, Podarcis)
Authors: Bassitta Marta , Buades Joana M. , Pérez‐Cembranos Ana , Pérez‐Mellado Valentín , Terrasa Barbara , Brown Richard P. , Navarro Pilar , Lluch Javier , Ortega Jesús , Castro Jose A. , Picornell Antònia , Ramon Cori 
Published: September 2020

AbstractThe phylogenetic relationships among the wall lizards of the Podarcis hispanicus complex that inhabit the south‐east (SE) of the Iberian Peninsula and other lineages of the complex remain unclear. In this study, four mitochondrial and two nuclear markers were used to study genetic relationships within this complex. The phylogenetic analyses based on mtDNA gene trees constructed with ML and BI, and a species tree using *BEAST support three divergent clades in this region: the Valencia, Galera and Albacete/Murcia lineages. These three lineages were also corroborated in species delimitation analyses based on mtDNA using bPTP, mPTP, GMYC, ABGD and BAPS. Bayesian inference species delimitation method (BPP) based on both nuclear data and a combined data set (mtDNA + nuclear) showed high posterior probabilities for these three SE lineages (≥0.94) and another Bayesian analysis (STACEY) based on combined data set recovered the same three groups in this region. Divergence time dating of the species tree provided an estimated divergence of the Galera lineage from the other SE group (Podarcis vaucheri, (Albacete/Murcia, Valencia)) at 12.48 Ma. During this period, the Betic–Rifian arc was isolated, which could have caused the isolation of the Galera form distributed to the south of the Betic Corridor. Although lizards from the Albacete/Murcia and Galera lineage are morphologically similar, they clearly represent distinct genetic lineages. The noteworthy separation of the Galera lineage enables us to conclude that this lineage must be considered as a new full species.
Geographic distribution of microsatellite alleles in geladas (Primates, Cercopithecidae): Evidence for three evolutionary units
Authors: Trede Franziska , Lemkul Anna , Atickem Anagaw , Beehner Jacinta C. , Bergman Thore J. , Burke Ryan , Fashing Peter J. , Knauf Sascha , Mekonnen Addisu , Moges Amera , Nguyen Nga , Roos Christian , Zinner Dietmar 
Published: September 2020

AbstractThe subspecific taxonomy and distribution of geladas (Theropithecus gelada Rüppell, 1835) remains uncertain. Recent molecular studies based on mitochondrial sequence data revealed a geographically structured, three‐deme population, suggesting that there are three evolutionary units of geladas. However, mitochondrial distributions do not always recover population relationships, particularly in taxa with a complex history of isolation and gene flow. We therefore analysed the nuclear genetic population structure of the global gelada population based on 20 microsatellite loci in 43 samples from across its geographic range. FST values, a STRUCTURE analysis and a principal coordinate analysis (PCoA) confirmed the three‐deme population structure corresponding to the mitochondrial population structure. Therefore, our analyses provide additional support for three evolutionary units in geladas, corresponding to (a) a northern (north of Lake Tana, primarily in the Simien Mountains, previously classified as Theropithecus gelada gelada Rüppell, 1835), (b) a central (between Addis Ababa and the highlands east of Lake Tana, previously classified as Theropithecus gelada obscurus Heuglin, 1863) and (c) a southern (south of the Rift Valley, previously tentatively classified as Theropithecus gelada arsi Shotake et al., 2016, Anthropological Science, 124, 157) population. These results pave the way for future conservation decisions and highlight that the gelada population boundaries need more fine‐grained genetic sampling and phenotypic analyses, in particular for their taxonomic ranking.
No effect of endoperoxide 4 or thromboxane A2 receptor blockade on static mechanoreflex activation in rats with heart failure
Authors: Butenas Alec L. E. , Rollins Korynne S. , Matney Jacob E. , Williams Auni C. , Kleweno Talyn E. , Parr Shannon K. , Hammond Stephen T. , Ade Carl J. , Hageman Karen S. , Musch Timothy I. , Copp Steven W. 
Published: September 2020

New Findings

What is the central question of this study?
Do endoperoxide 4 and thromboxane A2 receptors, which are receptors for cyclooxygenase products of arachidonic metabolism, on thin fibre muscle afferents play a role in the chronic mechanoreflex sensitization present in rats with heart failure with reduced ejection fraction (HF‐rEF)?

What is the main finding and its importance?
The data do not support a role for endoperoxide 4 receptors or thromboxane A2 receptors in the chronic mechanoreflex sensitization in HF‐rEF rats.

AbstractWe investigated the role of cyclooxygenase metabolite‐associated endoperoxide 4 receptors (EP4‐R) and thromboxane A2 receptors (TxA2‐R) on thin fibre muscle afferents in the chronic mechanoreflex sensitization in rats with myocardial infarction‐induced heart failure with reduced ejection fraction (HF‐rEF). We hypothesized that injection of either the EP4‐R antagonist L‐161,982 (1 µg) or the TxA2‐R antagonist daltroban (80 µg) into the arterial supply of the hindlimb would reduce the increase in blood pressure and renal sympathetic nerve activity (RSNA) evoked in response to 30 s of static hindlimb skeletal muscle stretch (a model of isolated mechanoreflex activation) in decerebrate, unanaesthetized HF‐rEF rats but not sham‐operated control rats (SHAM). Ejection fraction was significantly reduced in HF‐rEF (45 ± 11%) compared to SHAM (83 ± 6%; P < 0.01) rats. In SHAM and HF‐rEF rats, we found that the EP4‐R antagonist had no effect on the peak increase in mean arterial pressure (peak ΔMAP SHAM n = 6, pre: 15 ± 7, post: 15 ± 9, P = 0.99; HF‐rEF n = 9, pre: 30 ± 11, post: 32 ± 15 mmHg, P = 0.84) or peak increase in RSNA (peak ΔRSNA SHAM pre: 33 ± 14, post: 47 ± 31%, P = 0.94; HF‐rEF, pre: 109 ± 47, post: 139 ± 150%, P = 0.76) response to stretch. Similarly, in SHAM and HF‐rEF rats, we found that the TxA2‐R antagonist had no effect on the peak ΔMAP (SHAM n = 7, pre: 13 ± 7, post: 19 ± 14, P = 0.15; HF‐rEF n = 14, pre: 24 ± 13, post: 21 ± 13 mmHg, P = 0.47) or peak ΔRSNA (SHAM pre: 52 ± 43, post: 57 ± 67%, P = 0.94; HF‐rEF, pre: 108 ± 93, post: 88 ± 72%, P = 0.30) response to stretch. The data do not support a role for EP4‐Rs or TxA2‐Rs in the chronic mechanoreflex sensitization in HF‐rEF.
Impairments in path integration, rotational memory and balancing in patients with temporal lobe epilepsy
Authors: Dordevic Milos , Gruber Julia , Schmitt Friedhelm C , Mueller Notger 
Published: September 2020

ObjectivesThe vestibulo-medial temporal lobe (MTL) axis model proposes that the vestibular system and the MTL are tightly linked both structurally and functionally so that alterations of one structure should entail disturbances in the other. Accordingly, patients with temporal lobe epilepsy (TLE) with their functional and possible structural temporal lobe pathology should show deficits in vestibular-related behaviour. This study aimed at assessing behavioural deficits related to a suspected disturbance of the vestibulo-MTL axis in patients with TLE.MethodsTwenty patients with TLE (46.7±15.1 years, seven females) and their age-matched and gender-matched controls (46.7±15.1, seven females) underwent three test batteries that challenged vestibular and MTL functions: balancing, path integration (triangle completion test) and rotational memory. In addition, participants underwent a structural MRI for grey matter analysis using voxel-based morphometry.ResultsCompared with controls, patients with TLE showed significantly inferior performance in all three behavioural tests, with large effect sizes. There were no significant grey matter differences between the two groups.ConclusionThese results indicate a potential disturbance in the vestibulo-MTL axis in TLE; these are to be verified by future large-scale studies. In the current study, these behavioural deficits emerged without evidence of any brain volume differences between the patients and their controls as depicted by high-resolution MRI. This speaks for a dissociation between functional and structural alterations in TLE.
Rationale and description of a lifestyle intervention programme to achieve moderate weight loss in women with non-metastatic breast cancer: the lifestyle intervention part of the SUCCESS C Study
Authors: Hauner Dagmar , Rack Brigitte , Friedl Thomas , Hepp Philip , Janni Wolfgang , Hauner Hans 
Published: September 2020

ObjectiveThere is growing evidence from observational studies that lifestyle factors such as obesity, an unhealthy diet and lack of physical activity are associated with poor long-term outcome in women with breast cancer. The primary objective of the lifestyle modification part of the Simultaneous Study of Docetaxel Based Anthracycline Free Adjuvant Treatment Evaluation, as well as Life Style Intervention Strategies (SUCCESS C) Trial is to investigate the effect of an individualised lifestyle intervention programme aiming at moderate weight loss on disease-free survival in women with HER2/neu-negative breast cancer. Secondary objectives include the effect of the intervention on body weight, cardiovascular risk and quality of life.MethodsThe SUCCESS C Trial is an open-label, multicentre, randomised controlled phase III study using a 2×2 factorial design in women with newly diagnosed HER2/neu-negative intermediate-risk to high-risk breast cancer. The first randomisation served to compare disease-free survival in patients treated with two different chemotherapy regimens (3642 participants). The second randomisation served to compare disease-free survival in patients with a body mass index of 24–40 kg/m² (2292 participants) receiving either a telephone-based individualised lifestyle intervention programme for moderate weight loss or general recommendations for a healthy lifestyle for 2 years. Outcome analyses will be conducted after 5 years of follow-up.PerspectiveThis study will provide information on the efficacy and safety of a comprehensive lifestyle intervention programme on disease-free survival in a large cohort of women with breast cancer. EU Clinical Trials Identifier: 2008-005453-38.
Malignant cell-specific CXCL14 promotes tumor lymphocyte infiltration in oral cavity squamous cell carcinoma
Authors: Parikh Anuraag , Shin JuneHo , Faquin William , Lin Derrick T , Tirosh Itay , Sunwoo John B , Puram Sidharth V 
Published: September 2020

ObjectivesTo explore lymphocyte infiltration as a potential mechanism behind CXCL14-mediated tumor growth suppression in oral cavity squamous cell carcinoma (OSCC).MethodsWe analyzed single cell RNA-sequencing (scRNA-seq) data from OSCC to identify expression changes among malignant cells in lymph nodes (LN) versus primary tumors. CXCL14 expression in murine OSCC cell lines was quantified using qRT-PCR. Short hairpin RNA knockdown of CXCL14 was performed in mouse oral cavity (MOC)1 cells, and CXCL14 overexpression was performed in MOC2 cells. Cells in each condition were injected into C57BL/6 mice with and without T cell depletion, and tumor volume was measured. At 30 days, tumors were dissociated and analyzed by flow cytometry for CD45+CD3+ T cells. CXCL14 expression was correlated with gene expression signatures of tumor infiltrating lymphocytes (TIL) in scRNA-seq data, as well as TCGA tumors.ResultsscRNA-seq revealed CXCL14 as the most significantly downregulated gene among malignant cells in LNs relative to primary tumor, supporting a role in preventing invasion and/or metastasis. In a murine immunocompetent model, CXCL14 expression was higher in indolent MOC1 cells than in more aggressive MOC2 cells. Tumor growth in vivo was significantly increased by CXCL14 knockdown in MOC1 cells relative to control, with a corresponding decrease in TIL. In MOC2 cells, tumor growth was significantly reduced by CXCL14 overexpression relative to control and TIL were increased. Both effects were lost with T cell depletion. In a human tumor scRNA-seq cohort, we found that only malignant cell CXCL14, but not non-malignant cell or fibroblast CXCL14, was associated with TIL. Bulk CXCL14 from the TCGA cohort had no association with TIL.ConclusionsHigher CXCL14 expression by tumor cells is associated with reduced tumor growth and increased TIL, supporting immune-mediated suppression of tumor growth in OSCC. Given that CXCL14 is downregulated in LN metastases compared with primary tumors, our data raise the possibility that CXCL14-mediated immune infiltration may discourage invasion and metastasis. In human scRNA-seq data, only malignant cell-specific CXCL14 was associated with TIL, suggesting a critical context-dependent effect of CXCL14 expression.