bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of structural and process quality indicators on the outcomes of acute aortic dissection
Authors: Yamaguchi Tetsuo , Nakai Michikazu , Sumita Yoko , Miyamoto Yoshihiro , Matsuda Hitoshi , Inoue Yousuke , Yoshino Hideaki , Okita Yutaka , Minatoya Kenji , Ueda Yuichi , Ogino Hitoshi 
Published: July 2020

AbstractOBJECTIVESThe mortality of acute aortic dissection (AAD) remains high, and evidence-to-practice gaps exist in real-world treatment. We explored the first quality indicators (QIs) for AAD management and evaluated the associations between the achievement of these QIs and the outcome in a nationwide administrative database.METHODSA systematic search was performed to establish initial index items for QIs. An evaluation was performed through an expert consensus meeting using the Delphi method. We studied 18 348 patients who had AAD (type A: 10 131; type B: 8217) in the Japanese Registry of All Cardiac and Vascular Diseases database between April 2012 and May 2015. The associations between the achievement of QIs [categorized into tertiles (low, middle and high)] and in-hospital mortality were determined by multivariable mixed logistic regression analyses.RESULTS AND CONCLUSIONWe developed a total of 9 QIs (5 structural and 4 process). Lower achievement rates of QIs were significantly associated with higher in-hospital mortality in both types [type A = middle: odds ratio (OR) 4.03; 95% confidence interval (CI) 3.301–4.90; P &lt; 0.001; low: OR 15.68; 95% CI 11.67–21.06; P &lt; 0.001 vs high; type B = middle: OR 3.48; 95% CI 2.19–5.53; P &lt; 0.001; low: OR 7.79; 95% CI 4.65–13.06; P &lt; 0.001 vs high]. Various sensitivity analyses showed consistent results. High achievement rates of QIs were significantly associated with reduced in-hospital mortality. Evaluating each hospital’s management using QIs would help to equalize treatment quality and demonstrate the evidence-to-practice gaps in real-world treatments for AAD.
Superior vena cava aneurysm: an unusual mediastinal mass
Authors: Soares Souza Luciana Volpon , Souza Arthur Soares , Morales Márcia Maria , Marchiori Edson 
Published: July 2020

Abstract
Superior vena cava aneurysms are rare mediastinal vascular lesions. Aneurysms are classified as fusiform and saccular, with the latter being rarer than the former. We report the case of an asymptomatic 75-year-old woman who presented with a superior mediastinal mass. She underwent chest computed tomography angiography, which demonstrated a saccular aneurysm in the superior vena cava.
Late-Life Preparedness and Its Correlates: A Behavioral Perspective on Preparation
Authors: Kim-Knauss Yaeji , Lang Frieder R 
Published: July 2020

Abstract

Objectives
The present study examined the extent of late-life preparedness and its correlates. In accordance with behavior theories, we postulated that those who have prior experience with caregiving and who perceive such activities as more useful and less risky are more likely to engage in late-life preparatory activities. Because the perceived distance until aging-related life challenges become prevalent may play a role in late-life preparedness, we hypothesized that the effects of the correlates would vary depending on one’s subjective remaining life expectation (SRLE).

Methods
Building upon cross-sectional data including 581 German adults from 18 to 93 years, we fitted a hurdle model that separately analyzes the presence and variety of self-reported action engagement to better handle the zero-inflated count measure of preparatory activities.

Results
The results revealed that the effects of perceived utility, caregiving experience, and SRLE were significant for both the presence and variety of activities. SRLE was found to moderate the observed effects in the models: The effect of perceived utility on the presence of at least one late-life preparatory activity was larger for those with lower SRLE. In contrast, among those with higher SRLE, having provided care increased the variety of preparatory activities.

Discussion
Findings suggest that some of the examined psychosocial factors are similarly associated with both the presence of at least one and the variety of late-life preparatory activities, although the extent of their effects varies depending on one’s subjective life stage.
Development and Validation of a Workplace Age-Friendliness Measure
Authors: Eppler-Hattab Raphael , Doron Israel , Meshoulam Ilan 
Published: July 2020

AbstractBackground and ObjectivesMeasuring the extent to which the culture of organizations can be considered age-friendly is a significant anchor in the constructive inclusion process of older workers in workplaces, given the consistent aging of the workforce. Hence, the purpose of this research was to develop a novel, comprehensive, and theoretically driven measure of workplace age-friendliness.Research Design and MethodsThree multiphased, multisourced studies were conducted: a qualitative assessment procedure and 2 separate quantitative field surveys of individual-level perceptions.ResultsA 24-item scale of workplace age-friendliness was developed, consisting of 4 dimensions that represent the different ways in which organizational culture aligns with an aging and older workforce: age-friendly core culture, development, wellness, and flexibility. Confirmatory factor analysis verified that a 4-factor structure is the most appropriate solution, with all dimensions having acceptable internal consistency. Preliminary evidence of construct validity is also presented.Discussion and ImplicationsThe measure developed in this study may serve researchers as well as practitioners in the field of aging and work. Further implications and limitations of using this instrument in future empirical study on workplace age-friendliness are discussed.
What Keeps Them Going, and What Gets Them Back? Older Adults’ Beliefs About Physical Activity Maintenance
Authors: Huffman Mary Katherine , Amireault Steve 
Published: July 2020

Abstract

Background and Objectives
The overall purpose of this article was to investigate beliefs related to physical activity maintenance among adults aged 60 years or older.

Research Design and Methods
Study 1 identified modal, salient behavioral, normative, and control beliefs using a free-response format. Study 2 was designed to gain a deeper understanding about these beliefs through in-depth semistructured interviews.

Results
Findings indicate that perceived physical and emotional benefits, scheduling and having a physical activity routine, social support, and features of indoor and outdoor locations are facilitating of maintenance. Some beliefs appear more relevant to sustained engagement in physical activity, while others may be more helpful for reengagement after 1 week of inactivity.

Discussion and Implications
This investigation raises new hypotheses for future research and provides insight for the use and adaptation of behavior change strategies that are potentially more acceptable and effective for the promotion of physical activity maintenance for older adults.
Relative survival scenarios: an application to undersized common sole (Solea solea L.) in a beam trawl fishery in the Mediterranean Sea
Authors: Masnadi Francesco , Armelloni Enrico Nicola , Guicciardi Stefano , Pellini Giulio , Raicevich Saša , Mazzoldi Carlotta , Scanu Martina , Sabatini Laura , Tassetti Anna Nora , Ferrà Carmen , Grati Fabio , Bolognini Luca , Domenichetti Filippo , Cacciamani Roberto , Calì Federico , Polidori Piero , Fabi Gianna , Luzi Francesca , Giovanardi Otello , Bernarello Valentina , Pasanisi Eugenia , Franceschini Gianluca , Breggion Cristina , Bozzetta Elisa , Sambo Andrea , Prioli Giuseppe , Gugnali Andrea , Piccioni Elena , Fiori Fabio , Caruso Fabrizio , Scarcella Giuseppe 
Published: July 2020

Abstract
Fishery discard survival depends on multiple conditions; caution is essential when survival study outputs are employed to support management decisions. The study presents a stepwise procedure, devised to estimate discard survival, that accounts for the variability characterizing commercial fishing practices. The procedure was applied to the first survival study performed onboard rapido trawlers targeting Solea solea in the Mediterranean Sea. Undersized specimens collected during sorting were assessed for vitality; some were retained for captive observation. The main drivers affecting discard survival at the time of catch sorting (immediate survival) were identified and used to outline four different operational conditions set (scenarios). Immediate survival in each scenario was subsequently modified by applying a hazard coefficient of survival after 5 days of captive observation in relation to each vitality class, thus obtaining relative survival estimates following discarding. Temperature and air exposure duration were found to exert a major effect on survival, with catch weight and seabed type being additional important factors. The relative survival rate showed an aggregate value of 22.9% (10.5–33.4%). Scenario approach can enhance our understanding of the stressors influencing discard survival. The outcomes are discussed to explore the potential applications of the procedure to the identification of mitigation strategies.
Comparison between the Khorana prediction score and Caprini risk assessment models for assessing the risk of venous thromboembolism in hospitalized patients with cancer: a retrospective case control study
Authors: Hu Yuehong , Li Xiaoqian , Zhou Haixia , Lin Ping , Zhang Jiarui , Huang Dong , Qi Min , Tang Yongjiang , Yi Qun , Liang Zong’an , Wang Maoyun 
Published: July 2020

AbstractOBJECTIVESThis study aimed to evaluate the optimal risk assessment model (RAM) to stratify the risk of venous thromboembolism (VTE) in hospitalized patients with cancer. We examined and compared the VTE predictive ability of the Khorana score (KS) and the Caprini RAM in hospitalized cancer patients.METHODSWe performed a retrospective case–control study among hospitalized cancer patients admitted to a comprehensive hospital in China from January 2015 to December 2016. A total of 221 cases were confirmed to have VTE during hospitalization and 221 controls were selected randomly. The Caprini RAM and KS were implemented and the individual scores of each risk factor were summed to generate a cumulative risk score. Meanwhile, the sensitivity, specificity, areas under curve of the receiver operating characteristic curve and calibration of these 2 models were analysed.RESULTSSignificant differences were observed in risk factors between VTE and non-VTE hospitalized cancer patients and the VTE risk increased significantly with an increase in the cumulative KS or Caprini RAM score. A classification of ‘high risk’ according to KS and Caprini RAM was associated with 2.272-fold and 3.825-fold increases in VTE risk, respectively. However, the Caprini RAM could identify 82.4% of the VTE cases that required preventive anticoagulant therapy according to American College of Chest Physicians guidelines, whereas the KS could only identify 35.3% of the VTE cases. In addition, the areas under curve of Caprini RAM were significantly higher than those of the KS (0.705 ± 0.024 vs 0.581 ± 0.025, P &lt; 0.001), with a best cut-off value of 5 score, which happened to be the cut-off value for high risk of VTE in Caprini RAM. Both Caprini RAM and KS showed an excellent calibration curve (0.612 vs 0.141, P &gt; 0.05), but the risk of VTE events predicted by Caprini seemed closer to the observed risk of VTE events.CONCLUSIONSThe Caprini RAM was found to be more effective than the KS in identifying hospitalized patients with cancer at risk of VTE.
Natural gas development, flaring practices and paediatric asthma hospitalizations in Texas
Authors: Willis Mary , Hystad Perry , Denham Alina , Hill Elaine 
Published: July 2020

Abstract

Background
Recent advancements in drilling technology led to a rapid increase in natural gas development (NGD). Air pollution may be elevated in these areas and may vary by drilling type (conventional and unconventional), production volume and gas flaring. Impacts of NGD on paediatric asthma are largely unknown. This study quantifies associations between specific NGD activities and paediatric asthma hospitalizations in Texas.

Methods
We leveraged a database of Texas inpatient hospitalizations between 2000 and 2010 at the zip code level by quarter to examine associations between NGD and paediatric asthma hospitalizations, where our primary outcome is 0 vs ≥1 hospitalization. We used quarterly production reports to assess additional drilling-specific exposures at the zip code-level including drilling type, production and gas flaring. We developed logistic regression models to assess paediatric asthma hospitalizations by zip code-quarter-year observations, thus capturing spatiotemporal exposure patterns.

Results
We observed increased odds of ≥1 paediatric asthma hospitalization in a zip code per quarter associated with increasing tertiles of NGD exposure and show that spatiotemporal variation impacts results. Conventional drilling, compared with no drilling, is associated with odds ratios up to 1.23 [95% confidence interval (CI): 1.13, 1.34], whereas unconventional drilling is associated with odds ratios up to 1.59 (95% CI: 1.46, 1.73). Increasing production volumes are associated with increased paediatric asthma hospitalizations in an exposure–response relationship, whereas associations with flaring volumes are inconsistent.

Conclusions
We found evidence of associations between paediatric asthma hospitalizations and NGD, regardless of drilling type. Practices related to production volume may be driving these positive associations.
Tandospirone, a Partial 5-HT1A Receptor Agonist, Administered Systemically or Into Anterior Cingulate Attenuates Repetitive Behaviors in Shank3B Mice
Authors: Dunn Jeffrey T , Mroczek Jessica , Patel Harsh R , Ragozzino Michael E 
Published: July 2020

Abstract

Background
Several cases of autism spectrum disorder have been linked to mutations in the SHANK3 gene. Haploinsufficiency of the SHANK3 gene contributes to Phelan-McDermid syndrome, which often presents an autism spectrum disorder phenotype along with moderate to severe intellectual disability. A SHANK3 gene deletion in mice results in elevated excitation of cortical pyramidal neurons that alters signaling to other brain areas. Serotonin 1A receptors are highly expressed on layer 2 cortical neurons and are known to have inhibitory actions. Serotonin 1A receptor agonist treatment in autistic cases with SHANK3 mutations and possibly other cases may restore excitatory and inhibitory balance that attenuates core symptoms.

Methods
A series of experiments investigated the effects of acute tandospirone treatment on spatial learning and self-grooming, subchronic treatment of tandospirone on self-grooming behavior, and the effect of tandospirone infusion into the anterior cingulate on self-grooming behavior.

Results
Only male Shank3B+/− mice exhibited a spatial learning deficit and elevated self-grooming. Acute i.p. injection of tandospirone, 0.01 and 0.06 mg/kg in male Shank3B+/− mice, attenuated a spatial acquisition deficit by improving sensitivity to positive reinforcement and reduced elevated self-grooming behavior. Repeated tandospirone (0.06 mg/kg) treatment attenuated elevated self-grooming behavior in male Shank3B+/− mice. Tandospirone injected into the anterior cingulate/premotor area reduced self-grooming behavior in male Shank3B+/− mice.

Conclusions
These results suggest that stimulation of cortical serotonin 1A receptors may reduce repetitive behaviors and cognitive impairments as observed in autism spectrum disorder, possibly by attenuating an excitation/inhibition imbalance. Further, tandospirone may serve as a treatment in autism spectrum disorder and other disorders associated with SHANK3 mutations.
Signatures of Topological Branched Covers
Authors: Geske Christian , Kjuchukova Alexandra , Shaneson Julius L 
Published: July 2020

Abstract
Let $X^4$ and $Y^4$ be smooth manifolds and $f: X\to Y$ a branched cover with branching set $B$. Classically, if $B$ is smoothly embedded in $Y$, the signature $\sigma (X)$ can be computed from data about $Y$, $B$ and the local degrees of $f$. When $f$ is an irregular dihedral cover and $B\subset Y$ smoothly embedded away from a cone singularity whose link is $K$, the second author gave a formula for the contribution $\Xi (K)$ to $\sigma (X)$ resulting from the non-smooth point. We extend the above results to the case where $Y$ is a topological four-manifold and $B$ is locally flat, away from the possible singularity. Owing to the presence of points on $B$ which are not locally flat, $X$ in this setting is a stratified pseudomanifold, and we use the intersection homology signature of $X$, $\sigma _{IH}(X)$. For any knot $K$ whose determinant is not $\pm 1$, a homotopy ribbon obstruction is derived from $\Xi (K)$, providing a new technique to potentially detect slice knots that are not ribbon.
Liquid Biopsy to Detect Circulating Tumor Cells: Is It Ready for a Value Proposition in Laboratory Medicine?
Authors: Cortés-Hernández Luis Enrique , Eslami-S Zahra , Alix-Panabières Catherine 
Published: July 2020

Abstract
The long-term effects of cancer on patient quality of life and its economic burden are important issues that need to be addressed. Therefore, it is critical to assess patient priorities and investigate the value proposition of clinical tests in this field. The minimally invasive liquid biopsy has attracted much attention because it allows serial sampling during cancer progression, and provides valuable biological information on the tumor biology and treatment response through the analysis of analytes in the blood, such as circulating tumor cells (CTCs). To introduce CTC analysis in daily clinical practice, it is still necessary to firmly establish its clinical benefits and extra value for clinical decision-making. A laboratory medicine value proposition of CTC medical applications can help to address these issues. In this review, we discuss the current evidence for a value proposition of CTC detection, isolation, and characterization using the available technologies, and we summarize the unmet requirements for the full integration of CTCs in the care pathway.
An application to support COVID-19 occupational health and patient tracking at a Veterans Affairs medical center
Authors: Fillmore Nathanael R , Elbers Danne C , La Jennifer , Feldman Theodore C , Sung Feng-Chi , Hall Robert B , Nguyen Vinh , Link Nicholas , Zwolinski Robert , Dipietro Svitlana , Miller Stephen J , Aleksanyan Anahit , Goryachev Sergey D , Corcoran Paul , Bergstrom Steven J , Parenteau Michael A , Sprague Robert S , Thornton David J , Driver Jane A , Strymish Judith M , Evans Stewart , Colonna Benjamin , Brophy Mary T , Do Nhan V 
Published: July 2020

Abstract

Objective
Reducing risk of coronavirus disease 2019 (COVID-19) infection among healthcare personnel requires a robust occupational health response involving multiple disciplines. We describe a flexible informatics solution to enable such coordination, and we make it available as open-source software.

Materials and Methods
We developed a stand-alone application that integrates data from several sources, including electronic health record data and data captured outside the electronic health record.

Results
The application facilitates workflows from different hospital departments, including Occupational Health and Infection Control, and has been used extensively. As of June 2020, 4629 employees and 7768 patients and have been added for tracking by the application, and the application has been accessed over 46 000 times.

Discussion
Data captured by the application provides both a historical and real-time view into the operational impact of COVID-19 within the hospital, enabling aggregate and patient-level reporting to support identification of new cases, contact tracing, outbreak investigations, and employee workforce management.

Conclusions
We have developed an open-source application that facilitates communication and workflow across multiple disciplines to manage hospital employees impacted by the COVID-19 pandemic.
Distribution of Fluvoxamine and Identification of the Main Metabolite in a Fatal Intoxication
Authors: Vignali Claudia , Moretti Matteo , Quaiotti Jessica , Freni Francesca , Tajana Luca , Osculati Antonio Marco Maria , Morini Luca 
Published: July 2020

Abstract
Fluvoxamine is a selective serotonin reuptake inhibitor, with a half-life of about 30 hours, that is commonly prescribed in the treatment of depression and obsessive and compulsive disorders. Though its more favorable adverse effect profile in comparison to tricyclic antidepressants, overdosages could lead to severe central nervous system depression. We hereby report the case of a 48-year-old woman with psychiatric disorders, who died in the Protected Community where she lived. An autopsy, during which multiorgan congestion and aspiration of gastric content were found, was performed 9 days after the death. Femoral and cardiac blood, urine and bile were collected for toxicological analysis. GC–MS, LC–MS-MS and LC–HRMS screenings were performed on blood samples. The analysis allowed to identify the following drugs: fluvoxamine, clotiapine, 7-aminoclonazepam, propranolol, gabapentin and haloperidol. Quantification of the detected drugs in blood was performed by means of a validated LC–MS-MS analytical procedure, and the following results were achieved: fluvoxamine (2.20 mg/L), gabapentin (41.00 mg/L), 7-aminoclonazepam (0.24 mg/L), clotiapine (0.07 mg/L), haloperidol (&lt;0.01 mg/L) and propranolol (0.24 mg/L). Fluvoxamine concentration in blood exceeded ~10 times the upper limit of therapeutic blood levels (0.23 mg/L). Contributory causes of death, such as due to multiple drug use, however, cannot be excluded. The distribution of fluvoxamine in all biological fluids was evaluated and a postmortem redistribution effect was observed (C/P blood ratio: 1.86). Fluvoxamine acid metabolite was identified in urine, bile and in cardiac blood, through an LC–QTOF analytical procedure.
Registration method for maintenance-work support based on augmented-reality-model generation from drawing data
Authors: Lee Won-Hyuk , Lee Kyung-Ho , Lee Jung-Min , Nam Byeong-Wook 
Published: July 2020

Abstract
The importance of operations and maintenance (O&M) and piping inspection in shipbuilding and offshore plant industries has significantly increased recently. Therefore, this study proposes a system that uses augmented reality (AR) to support these operations. AR in O&M and inspection systems can increase work comprehension and efficiency by utilizing 3D graphics, instead of drawings, to describe specific work functions. To realize this improvement, the augmented model should correspond to the reality; if accurate registration is not achieved, it can disrupt the work functions. Therefore, marker-based AR is used to generate specific recognition objects and correct the location of the augmented model. However, owing to certain characteristics of the shipbuilding and offshore plant industries, the markers are likely to be damaged, and thus the cameras fail to clearly detect them. In this study, a 3D camera was used to generate a point cloud based on 3D image information. Accordingly, the area around the model to be detected was designated as the region of interest (ROI). Furthermore, it is difficult to support a high-end device environment because it is tested as a portable device that can be used in a working environment; therefore, superfluous data were removed by detecting the 3D edges in the ROI, thereby minimizing data operation. The scalability of this work was enhanced using the computer-aided design (CAD) file information extracted from the CAD tool (used in the shipbuilding industry) and converting it into a point cloud. The proposed system is expected to eliminate the issues related to understanding the O&M work by addressing registration errors that might occur in constrained environments and to improve the torsional phenomenon of the augmented models.