bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design thinking and radical innovation: enter the smartwatch
Authors: Radnejad Amir Bahman , Ziolkowski Michael F. , Osiyevskyy Oleksiy 
Published: July 2020

Purpose
This paper aims to expand the understanding of the design thinking (DT) field and provides evidence that DT as an innovation mindset centered on user/human needs is able to lead enterprises to the development of radical product innovation.

Design/methodology/approach
The study is based on an illustrative case analysis of four eras of radical innovations in the watch industry, from the mechanical wristwatches to smartwatches.

Findings
The findings from the watch industry substantiate the developed DT triangle framework for designers, managers and executives, enabling the development of radical product innovation.

Originality/value
The study provides evidence for the claim that human-centered approach (rather than design-driven, meaning-changing approach) in DT can successfully lead to radical product innovations. For this, this paper distinguishes between “need” and “meaning” in the DT field and reemphasize the role of creating empathy with users to be able to identify their newly shaped needs. Fulfilling these newly shaped needs would ultimately result in the development of radically new products.
Relationship between role overload and the work–family interface
Authors: Vatharkar Poonam Shripad , Aggarwal-Gupta Meenakshi 
Published: July 2020

PurposeThe purpose of this study is to investigate the relationship between role overload (RO) and the work–family interface (work–life conflict and work–life enrichment) among bank employees and the moderating effects of personal life characteristics and commitments on this relationship. It aimed to bring out the importance of contextual factors in individual's interactions across various roles.Design/methodology/approachA structured questionnaire based on validated instruments was designed and administered to 279 employees from the banking sector in India. The instrument was adapted to the local language to ensure ease of comprehension.FindingsRO was positively correlated with both work interference with personal life (WIPL) and personal life interference with work (PLIW), and negatively correlated with work–personal life enrichment (WPLE). Gender, number of children and age of the youngest child significantly moderated the relationship between RO and WIPL.Research limitations/implicationsThis study was limited by the use of self-reported data and its cross-sectional nature. Future studies will need to include a larger sample with people from across the workplace hierarchy.Practical implicationsThis paper provides valuable insight into the influence of personal life characteristics and commitments on RO and the work–family interface.Originality/valueThe banking sector is among the top 10 most stressful workplaces in India due to high work pressure and the threat of competition. These working conditions make it important to understand employee perceptions of RO and its impact on the work–family interface.
Diatom defence: Grazer induction and cost of shell‐thickening
Authors: Grønning Josephine , Kiørboe Thomas 
Published: July 2020

Abstract

Diatoms account for 40% of the ocean primary production and play a key role in the oceans’ ability to sequester carbon. The evolutionary success of diatoms and their role in ocean biogeochemistry are related to the siliceous shell that provide partial protection against grazing.

The structure and function of phytoplankton communities are governed by environmental constraints and organismal trade‐offs. Defence mechanisms may help explain the high diversity of phytoplankton (incl. diatoms) in the ocean, but only if the defence comes at a cost. Defence costs have been notoriously difficult to demonstrate and quantify in marine phytoplankton.

Here, we demonstrate for seven species of planktonic diatoms that their shell thickens and their growth rate declines when cells are exposed to chemical cues from copepods, important predators of diatoms. The responses are proportional to the concentration of grazer cues, but are also highly variable, both between and within species.

At our standard experimental condition, the typical decline in growth rate is 10%, and the typical increase in cellular biogenic silica is 16%. The latter value corresponds to a decline in grazing mortality due to small copepods of 11%. Thus, silification in response to grazers is exactly warranted.

The similar magnitude of the costs and benefits of silification suggests a flat fitness landscape along the competition‐defence axis. This may help explain the high diversity of coexisting diatoms in the ocean.

The significant but variable contribution of diatoms to the downward flux of organic carbon in the ocean depends to a large extent on the silica content of the cells. This is due less to the ballasting effect of silica, but mainly to the different life histories of more or less defended cells that are governed by evolutionary adaptations and—as demonstrated here—plastic responses to grazers.

A free Plain Language Summary can be found within the Supporting Information of this article.
Plasma volume treated with double filtration plasmapheresis and outcomes of acute antibody‐mediated rejection in kidney transplant recipients: A retrospective cohort study
Authors: Noppakun Kajohnsak , Kittipanyaworakun Thanapat , Ruengorn Chidchanok , Vongsanim Surachet , Saikam Anchalee , Khamlueang Nikhom 
Published: July 2020

AbstractA retrospective cohort study was conducted to evaluate the association between the plasma volume treated by double filtration plasmapheresis and allograft outcomes for the treatment of acute antibody‐mediated rejection in kidney transplant recipients. Patients were divided into two groups: group 1, plasma volume treated between 1 and <1.3 total plasma volume and group 2, plasma volume treated ≥1.3 total plasma volume. Primary outcome was ≥50% reduction of serum creatinine rising from baseline value at 1 month. A total of 32 courses (146 sessions) of double filtration plasmapheresis were performed; 17 and 15 courses in group 1 and group 2, respectively. Primary outcome occurred in 41% of group 1 and 40% of group 2 (adjusted risk ratio 1.15 [95%CI, 0.48‐2.76]). Graft loss at 1 year did not differ between the two groups (adjusted hazard ratio 0.65 [95%CI, 0.23‐1.87]). Infection tendency seemed to be higher in group 2 (40% vs 18%, P = .243).
Learning from animations and computer simulations: Modality and reverse modality effects
Authors: Liu Tzu‐Chien , Lin Yi‐Chun , Hsu Chih‐Yi , Hsu Chung‐Yuan , Paas Fred 
Published: July 2020

AbstractAlthough a modality effect indicating better learning from an animation with spoken learning guidance than from an animation with written learning guidance has often been found in research on learning from animation, the effect has hardly been investigated for learning from computer simulation. This study examined the interaction effects between the multimedia types of animation and computer simulation, and the presentation modes of written and spoken learning guidance. Based on cognitive load theory and the specific characteristics of the multimedia types it was hypothesized that a modality effect would be replicated in the animation condition and a reverse modality effect would be found in the simulation condition. Results partially supported the hypotheses, indicating that participants learned more from animation when it was accompanied with spoken text, and from a simulation when it was accompanied with written text. However, no effect was found for cognitive load. Based on the results, spoken text is recommended to be used to guide learners in animations assisted learning environments, and written text is recommended to be used to guide learners in simulations assisted learning environments.
Practitioner NotesWhat is already known about this topic

Animation and computer simulation have been widely used in different learning fields.
Modality effect means that students learn more from graphical representations when they are accompanied with spoken text instead of written text.
The modality effect has been verified in different learning environments.
What this paper adds

Examined the interaction effects between the multimedia types of animation and computer simulation, and the presentation modes of written and spoken text in a learning guide.
Provided recommendations for designing the leaning guide of animation and simulation based on cognitive load theory.
Implications for practice and/or policy

Modality effect was verified in animation, and thus, spoken text is more suitable for learning from animation.
Reversed modality effect was found in simulation condition, and thus, written text is more suitable for learning from simulation.
Seeing Iconic Gesture Promotes First‐ and Second‐Order Verb Generalization in Preschoolers
Authors: Aussems Suzanne , Kita Sotaro 
Published: July 2020

This study investigated whether seeing iconic gestures depicting verb referents promotes two types of generalization. We taught 3‐ to 4‐year‐olds novel locomotion verbs. Children who saw iconic manner gestures during training generalized more verbs to novel events (first‐order generalization) than children who saw interactive gestures (Experiment 1, N = 48; Experiment 2, N = 48) and path‐tracing gestures (Experiment 3, N = 48). Furthermore, immediately (Experiments 1 and 3) and after 1 week (Experiment 2), the iconic manner gesture group outperformed the control groups in subsequent generalization trials with different novel verbs (second‐order generalization), although all groups saw interactive gestures. Thus, seeing iconic gestures that depict verb referents helps children (a) generalize individual verb meanings to novel events and (b) learn more verbs from the same subcategory.
Etoricoxib‐induced fixed drug eruption: Report of seven cases
Authors: Martínez Antón Maria Dolores , Galán Gimeno Cristina , Sánchez de Vicente Javier , Jáuregui Presa Ignacio , Gamboa Setién Pedro M. 
Published: July 2020

AbstractBackgroundFixed drug eruption (FDE) is a characteristic form of intraepidermal CD8+ T cell‐mediated drug reaction, with repeated appearance of isolated or multiple skin lesions in the same location after receiving the offending drug. Non‐steroidal anti‐inflammatory drugs (NSAID) are the most common cause. Selective inhibitors of inducible cyclooxygenase 2 (COX‐2) provoke a lesser degree of allergic or idiosyncratic adverse reactions than conventional NSAID, but they can cause skin reactions of variable severity.ObjectiveEtoricoxib has been related to a variety of unusual skin reactions, including several reports of FDE.MethodsWe perfomed epicutaneous test to diagnose patients with suspected etoricoxib fixe drug rash due to clinical features and reproducibility on at least two occasions.ResultsWe present seven new cases of etoricoxib‐induced fixed drug eruption, with a diagnosis based on clinical presentation. This diagnosis was confirmed by an etoricoxib‐positive lesional patch test in six cases and by a positive low‐dose oral challenge in the other one. Two patients showed negative patch tests with celecoxib (10% in pet.) on the residual lesions, and oral tolerance was confirmed in one.ConclusionTo our knowledge, this is the largest series on FDE induced by etoricoxib reported to date.
Emicizumab treatment: Impact on coagulation tests and biological monitoring of haemostasis according to clinical situations (BIMHO group proposals)
Authors: Nougier Christophe , Jeanpierre Emmanuelle , Ternisien Catherine , Proulle Valérie , Hezard Nathalie , Pouplard Claire , Lasne Dominique ,   With contributions from the Working Group on Biology of Haemorrhagic Disorders (BIMHO, Under the Aegis of GFHT)
Published: July 2020

AbstractEmicizumab, a bispecific humanised monoclonal antibody restoring to some extent the function of activated FVIII deficient in haemophilia A, represents a major therapeutic advance in the management of haemophilia A patients. No dosage adjustment is required, which leads to a major change for patients used to regular biological monitoring which is particularly burdensome in the case of substitution therapy. In some circumstances, such as before an invasive procedure or in case of bleeding, biological monitoring will be necessary and emicizumab's interference with haemostasis tests, particularly those based on an activated partial thromboplastin times (aPTT), must be known to best interpret the tests and to select the most appropriate methods to guide therapy. The normalisation of aPTT in patients treated with emicizumab is not sufficient to consider haemostasis as normalised. In the event of administration of FVIII to a patient receiving emicizumab, the determination of FVIII should use a chromogenic method using non‐human reagents. Coagulation global tests have been proposed to evaluate the biological response when using bypassing agents in patients treated with emicizumab, but the usefulness must be confirmed. The French group BIMHO presents proposals for biological monitoring of a patient treated with emicizumab according to clinical situations.
Moyamoya disease in a European setting: a Danish population‐based study
Authors: Birkeland P. , Tharmabalan V. , Lauritsen J. , Ganesan V. , Bjarkam C. R. , von Weitzel‐Mudersbach P. 
Published: July 2020

Background and purposeThe incidence of moyamoya disease (MMD) in Europe is not well known. In those affected, the risk of brain hemorrhage is considered low. The present study aimed to investigate the incidence and clinical presentation of MMD in the Danish population.MethodsEligible patients were identified in the Danish National Patient Register from 1994 to 2017. We collected clinical and radiological data from individual patient records from neurological, neurosurgical and paediatric units across Denmark. The diagnosis was validated according to established criteria. We also extracted basic demographic data on the cohort from the Danish Civil Registration System.ResultsA total of 52 patients fulfilled the diagnostic criteria for MMD. Most patients were native Danes and only 15% had an East Asian background. The ratio of female to male patients was 1.8, and the incidence had two peaks: one in childhood and another in young middle age. Until 2007, MMD was only diagnosed sporadically. From 2008 onwards, the incidence rate was 0.07 per 100 000 person‐years (95% confidence interval 0.05–0.09 per 100 000 person‐years). The most common mode of presentation was ischaemic stroke (33%), followed by hemorrhage (23%), headache (17%) and transient ischaemic attack (14%).ConclusionsMoyamoya disease is rare in Denmark, but is associated with a considerable risk of hemorrhage. Thus, MMD should be considered in the evaluation for ischaemic as well as hemorrhagic stroke paediatric and middle‐aged Caucasians.
Are northern mockingbirds classic open‐ended song learners?
Authors: Gammon David E. 
Published: July 2020

AbstractThe northern mockingbird (Mimus polyglottos, Linnaeus) is considered a classic example of a species in which individuals learn songs throughout adulthood, but this assumption has not been tested rigorously. To assess whether mockingbirds should be categorized as open‐ended learners, I conducted a longitudinal study and a field‐based song‐tutoring experiment. I recorded songs from 15 free‐living, banded, adult males in an earlier year and a later year, and I classified 400 mimetic songs per year per individual, based on the species and vocalization type mimicked. For two of these “mimetic types,” I further classified all the song types of all individuals in their early and later samples. The number of song types increased significantly across years for both mimetic types, and the average number of observed mimetic types per individual was 46.4 and 47.7 in the early and late samples (p = .055). I found no evidence adults learned any tutor stimuli after six months of tutoring, but examples from the scientific literature suggest the tutoring regime might not have been adequate to pass the motivational threshold required for learning. I conclude that mockingbirds probably are open‐ended learners, but that future research is needed to verify experimentally that adults can indeed imitate novel song types.
Keeping control of regulation? Domestic constraints on the creation of independent authorities in emerging and developing economies
Authors: Koop Christel , Kessler Philip 
Published: July 2020

AbstractRegulatory independence has become an international norm over the past decades. Yet, governments in some emerging and developing economies have eschewed the model. We argue that this outcome is shaped by the domestic institutional context; in particular, authoritarianism and traditions of state control over the economy. Analyzing new data on the adoption and operation of independent competition authorities between 1990 and 2017, we find that authoritarianism and, to some extent, state‐led economic traditions negatively affect formal adoption. By contrast, these institutional constraints do not have much impact on the start of the operations, which seems to be driven primarily by capacity and economic need. Our findings shed light on domestic institutional constraints on the spread of international norms and the limits of “regulatory transplants” in the Global South.
Unravelling the knowledge, beliefs, behaviours and concerns of Persons with Haemophilia and their carriers in Senegal
Authors: Babington‐Ashaye Awa , Diop Saliou , Geissbuhler Antoine , de Moerloose Philippe 
Published: July 2020

AbstractIntroductionIn many sub‐Saharan countries, haemophilia exists in an environment of poor knowledge and poor access to treatment. To improve the quality of life of Persons with Haemophilia (PWH), understanding their unmet needs and the socio‐cultural realities is essential.AimThis study aims to explore disease knowledge, beliefs, behaviours and concerns of PWH and carriers as a way to find adapted solutions to address the unmet needs.MethodsBased on an interview guide, we performed a qualitative study with in‐depth interviews of 26 PWH and 14 carriers.ResultsEighty per cent of adult PWH were able to name the severity of haemophilia, but only 32% could describe with accuracy the mode of transmission of haemophilia. Only 23% of carriers were able to inform the severity of the disease. All carriers and adult PWH acknowledged at least one visit to a traditional healer. Acceptance of the disease through religion is the dominant coping strategy observed. High costs of treatment, fear of social rejection, difficulty of management of pain and bleeding at home were the main concerns.ConclusionsResults demonstrate important gaps in knowledge, especially within the carrier population, mothers in Africa playing particularly an important role in the survival and empowerment of PWH. Findings also indicate the important weight of cultural determinants in disease management and behaviours of PWH and thus their important role in the development of educational materials taking into account these determinants.
Epidural/spinal anesthesia during delivery in women with factor XI deficiency, a single center experience
Authors: Shacham Abulafia Adi , Yaniv Yuval , Steimatzky Arza , Orbach‐Zinger Sharon , Hadar Eran , Shmueli Anat , Borovich Adi , Ziv Ester , Rozovski Uri , Wiznitzer Arnon , Eidelman Leonid A. , Raanani Pia , Spectre Galia 
Published: July 2020

AbstractIntroductionThe safety of neuro‐axial anaesthesia (epidural/spinal) at labour of women with partial factor XI (FXI) deficiency is uncertain. Although FXI deficiency is frequent in Ashkenazi Jews, it is not routinely measured before labour. Our institute serves a large Ashkenazi population. We assumed that 10% of them have undiagnosed FXI deficiency.AimAssess the incidence, bleeding tendency and coagulation status among Jewish Ashkenazi women with FXI deficiency that underwent neuro‐axial anaesthesia at delivery.MethodsJewish Ashkenazi women who underwent neuro‐axial anaesthesia at labour completed the SSC ISTH bleeding assessment tool (BAT) and had blood drawn for coagulation tests, FXI and thrombin generation after labour. Estimation for 10 years was calculated from the 1‐year sample.ResultsWe recruited 261 women during 12 months. Among them, 39 (15%) had FXI deficiency (<70%) with median FXI levels of 63% (range: 33%‐70%). Around 50% of them underwent amniocentesis in the current pregnancy and prior neuro‐axial anaesthesia with no bleeding complications. BAT score and thrombin generation did not differ between women regardless of FXI status. aPTT was longer in women with partial FXI deficiency (median ‐ 28.6 sec vs 26.3 sec, P < .001, Table 2), although within the normal range in all women. No bleeding complications after neuro‐axial anaesthesia at delivery were reported in our centre in the last decade though, and according to our estimation, at least 2150 women had partial FXI deficiency.ConclusionsA significant number of Jewish Ashkenazi women with undiagnosed partial FXI deficiency undergo neuro‐axial anaesthesia at labour without bleeding complications.
Etiologies of severe acute respiratory infection (SARI) and misdiagnosis of influenza in Indonesia, 2013‐2016
Authors: Aman Abu Tholib , Wibawa Tri , Kosasih Herman , Asdie Rizka Humardewayanti , Safitri Ida , Intansari Umi Solekhah , Mawarti Yuli , Sudarmono Pratiwi , Arif Mansyur , Puspitasari Dwiyanti , Alisjahbana Bachti , Parwati Ketut Tuti Merati , Gasem Muhammad Hussein , Lokida Dewi , Lukman Nurhayati , Hartono Teguh Sarry , Mardian Yan , Liang C Jason , Siddiqui Sophia , Karyana Muhammad , Lau Chuen‐Yen 
Published: July 2020

AbstractBackgroundSevere acute respiratory infection (SARI) accounts for a large burden of illness in Indonesia. However, epidemiology of SARI in tertiary hospitals in Indonesia is unknown. This study sought to assess the burden, clinical characteristics, and etiologies of SARI and concordance of clinical diagnosis with confirmed etiology.MethodsData and samples were collected from subjects presenting with SARI as part of the acute febrile Illness requiring hospitalization study (AFIRE). In tertiary hospitals, clinical diagnosis was ascertained from chart review. Samples were analyzed to determine the “true” etiology of SARI at hospitals and Indonesia Research Partnership on Infectious Diseases (INA‐RESPOND) laboratory. Distribution and characteristics of SARI by true etiology and accuracy of clinical diagnosis were assessed.ResultsFour hundred and twenty of 1464 AFIRE subjects presented with SARI; etiology was identified in 242 (57.6%), including 121 (28.8%) viruses and bacteria associated with systemic infections, 70 (16.7%) respiratory bacteria and viruses other than influenza virus, and 51 (12.1%) influenza virus cases. None of these influenza patients were accurately diagnosed as having influenza during hospitalization.ConclusionsInfluenza was misdiagnosed among all patients presenting with SARI to Indonesian tertiary hospitals in the AFIRE study. Diagnostic approaches and empiric management should be guided by known epidemiology. Public health strategies to address the high burden of influenza should include broad implementation of SARI screening, vaccination programs, clinician education and awareness campaigns, improved diagnostic capacity, and support for effective point‐of‐care tests.