bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of age on the occurrence of adverse events in rheumatic patients at the onset of biological treatment: data from the BIOBADASER III register
Authors: Vela Paloma , Sanchez-Piedra Carlos , Perez-Garcia Carolina , Castro-Villegas María C. , Freire Mercedes , Mateo Lourdes , Díaz-Torné Cesar , Bohorquez Cristina , Blanco-Madrigal Juan M. , Ros-Vilamajo Inmaculada , Gómez Silvia , Caño Rocio , Sánchez-Alonso Fernando , Díaz-González Federico , Gómez-Reino Juan J. 
Published: June 2020

Abstract
Objectives
To assess whether age, at the beginning of biologic treatment, is associated with the time a first adverse event (AE) appears in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), or psoriatic arthritis (PsA).

Methods
All patients in the BIOBADASER registry diagnosed with RA, AS, and PsA, and classified as young (< 25 years old), adult (25–64 years old), elderly (65–75 years old) or very elderly (> 75 years old) at start of biological treatment were included. Factors associated with the appearance of a first AE using adjusted incidence rate ratios (IRR) (Poisson regression) were analyzed. Survival to first AE was studied by Kaplan-Meier analysis and hazard ratios (HR) by Cox regression.

Results
2483 patients were included: 1126 RA, 680 PsA, and 677 AS. Age group stratification was as follows: 63 young, 2127 adults, 237 elderly, and 56 very elderly. Regression model revealed an increased probability of suffering a first AE at age 65 years or older [IRR elderly: 1.42 (CI95% 1.13–1.77)]. Other characteristics associated with AE were female gender, the use of DMARDs, including methotrexate, the presence of comorbidities, and the time of disease duration. Factors that had the greatest impact on survival over a first AE were age > 75 years [HR 1.50 (1.01–2.24)] and female gender [HR 1.42 (1.22–1.64)].

Conclusion
Age at the start of treatment and female gender are key factors associated with the appearance of a first AE with biologics. Other factors related to patient status and treatment were also associated with a first AE in rheumatic patients treated with biologics.
The role of O-polysaccharide chain and complement resistance of Escherichia coli in mammary virulence
Authors: Salamon Hagit , Nissim-Eliraz Einat , Ardronai Oded , Nissan Israel , Shpigel Nahum Y. 
Published: June 2020

AbstractMastitis, inflammation of the mammary gland, is a common disease of dairy animals. The disease is caused by bacterial infection ascending through the teat canal and mammary pathogenic Escherichia coli (MPEC) are common etiology. In the first phase of infection, virulence mechanisms, designated as niche factors, enable MPEC bacteria to resist innate antimicrobial mechanisms, replicate in milk, and to colonize the mammary gland. Next, massive replication of colonizing bacteria culminates in a large biomass of microbe-associated molecular patterns (MAMPs) recognized by pattern recognition receptors (PRRs) such as toll-like receptors (TLRs) mediating inflammatory signaling in mammary alveolar epithelial cells (MAEs) and macrophages. Bacterial lipopolysaccharides (LPSs), the prototypical class of MAMPs are sufficient to elicit mammary inflammation mediated by TLR4 signaling and activation of nuclear factor kB (NF-kB), the master regulator of inflammation. Using in vivo mastitis model, in low and high complements mice, and in vitro NF-kB luminescence reporter system in MAEs, we have found that the smooth configuration of LPS O-polysaccharides in MPEC enables the colonizing organisms to evade the host immune response by reducing inflammatory response and conferring resistance to complement. Screening a collection of MPEC field strains, we also found that all strains were complement resistant and 94% (45/48) were smooth. These results indicate that the structure of LPS O-polysaccharides chain is important for the pathogenesis of MPEC mastitis and provides protection against complement-mediated killing. Furthermore, we demonstrate a role for complement, a key component of innate immunity, in host-microbe interactions of the mammary gland.
High-dose methotrexate in ICU patients: a retrospective study
Authors: Valade Sandrine , Mariotte Eric , Azoulay Elie , Darmon Michael 
Published: June 2020

Abstract
Background
High-dose methotrexate (HD-MTX) is commonly used in the treatment of solid tumors and hematological malignancies. Severe toxicities are frequent, leading to organ dysfunction and death. Risk–benefit ratio of using HD-MTX in critically ill patients is unknown. This study aims to describe MTX-induced toxicities and to assess outcome in ICU patients. We conducted a retrospective single-center study conducted in a university hospital ICU between January 2002 and December 2018. Consecutive patients treated by HD-MTX were included.

Results
33 patients (24 men and 9 women) aged 48 years [34–63], were included. B cell lymphoma had been diagnosed in 31 patients (Burkitt, n = 14; diffuse large B-cell lymphoma with CNS (central nervous system) involvement, n = 9; primary CNS lymphoma, n = 5) and T-cell lymphoma in two patients. Patients were mainly admitted for coma (n = 14; 42%) or acute kidney injury (n = 8; 24%). MTX was administered at a median dose of 6.1 g [5–14]. Fourteen patients had concomitant medication interacting with MTX. Median MTX clearance was 4 days [4–5]. Frequent MTX-related complication were mucositis (n = 21, 64%), diarrhea (n = 14, 44%) or hepatic failure (n = 15, 45%). During ICU stay, 11 patients experienced acute kidney injury (KDIGO stage 3 [2–3]). Two patients received carboxypeptidase and three underwent dialysis. Overall, 19 patients (57%) required mechanical ventilation, 10 (30%) vasopressors. Hospital mortality was 30% (n = 10). Cox model identified MTX concentration 24 h after administration higher than 4.6 µmol/L as associated with hospital mortality (HR 6.7; 95% CI 1.6–27.3).

Conclusions
To our knowledge, this is the first study assessing characteristics and outcome of critically ill patients receiving HD-MTX. MTX concentration at H24 was associated with hospital mortality. Despite underlying malignancy, ICU support of these patients was associated with a meaningful survival.
Fredholm type integral equation in extended $M_{b}$-metric spaces
Authors: Mlaiki Nabil , Hajji Mohamed , Abdeljawad Thabet 
Published: June 2020

AbstractIn this manuscript, we prove some new fixed point results for a self-mapping on extended $M_{b}$Mb-metric spaces, under some new types of contractions, which generalizes many results in the literature. Also, we present some interesting examples to illustrate our work.
Diabetes mellitus in dogs attending UK primary-care practices: frequency, risk factors and survival
Authors: Heeley Angela M. , O’Neill Dan G. , Davison Lucy J. , Church David B. , Corless Ellie K. , Brodbelt Dave C. 
Published: June 2020

AbstractBackgroundDiabetes mellitus (DM) is an important endocrine disorder of dogs. The objectives of this study were to estimate prevalence and incidence of DM in dogs, and to explore risk factors for DM and the survival of DM cases in primary-care clinics in the UK.ResultsA case-control study nested in the cohort of dogs (n = 480,469) aged ≥3 years presenting at 430 VetCompass clinics was used to identify risk factors for DM, using multivariable logistic regression. Overall 409 new and 863 pre-existing DM cases (total 1272) were identified in 2016, giving an apparent annual prevalence of 0.26% (95% confidence interval (CI): 0.25–0.28%), and an annual incidence risk of 0.09% (95%CI: 0.08–0.09%) in dogs aged ≥3 years. Factors associated with increased odds for DM diagnosis were all age categories > 8 years, female entire dogs (odds ratio (OR): 3.03, 95% CI 1.69–5.44,p < 0.001) and male neutered dogs (OR: 1.99, 95% CI 1.18–3.34,p = 0.010) compared to male entire dogs, Border Terriers (OR: 3.37, 95% CI 1.04–10.98,p = 0.043) and West Highland White Terriers (WHWT) (OR: 2.88, 95% CI 1.49–5.56,p = 0.002) compared to crossbreeds. Dogs that had received previous glucocorticoid treatment (OR: 2.19, 95% CI 1.02–4.70,p = 0.044) and those with concurrent conditions (documented obese, pancreatitis, hyperadrenocorticism) also had increased odds for DM diagnosis.Cox regression modelling was used to evaluate factors associated with survival in the 409 incident DM cases in 2016. Increased hazard of death following diagnosis of DM was shown in dogs that were ≥ 10 years age, Cocker Spaniels (HR: 2.06, 95% CI 1.06–4.01,p = 0.034) compared to crossbreeds, had a blood glucose (BG) level at diagnosis > 40 mmol/L (HR: 2.73, 95% CI 1.35–5.55,p = 0.005) compared to < 20 mmol/L at diagnosis, or had received previous glucocorticoid treatment (HR: 1.86, 95% CI 1.21–2.86,p = 0.005). Dogs at reduced hazard of death included neutered dogs (HR: 0.58, 95% CI 0.42–0.79,p = 0.001), Border Collies (HR: 0.39, 95% CI 0.17–0.87,p = 0.022) and those starting insulin treatment (HR: 0.08 95% CI 0.05–0.12,p < 0.001).ConclusionsCertain breeds and concurrent health conditions are associated with an increased risk of DM. In addition to certain signalment factors, a high BG level at diagnosis and prior glucocorticoid treatment were adversely associated with survival of dogs with DM.
Individualized body bioelectrical impedance parameters in newly diagnosed cancer children
Authors: Luna Taira Teresa Batista , González Maraelys Morales , Jarque Manuel Verdecia , González Tamara Rubio , Brooks Soraida Candida Acosta , Castañeda Antonio Rafael Selva , Regüeiferos Justa Carmen Columbié , González Victoriano Gustavo Sierra , Cabrales Luis Enrique Bergues 
Published: June 2020

Abstract
Background
The bioelectric impedance analysis permits to estimate electrical parameters and body composition of subjects who are either apparently healthy or sick with different pathologies. The aim of this study is to individualize the analysis of body bioelectrical impedance parameters in newly diagnosed cancer children, by means of the bioelectrical impedance analysis for each age group, gender and cancer histological variety.

Methods
This retrospective cross-sectional study consisted of 43 pediatric patients with different histological varieties of cancer, ages from 2 to 17. The body electrical resistance and body capacitive electrical reactance were measured with the Bodystat 1500-MDD analyzer. From these two electrical parameters the body electrical impedance modulus and the body phase angle were calculated.

Results
The results showed that 93.02% of cancer children were outside reference rectangles according to age groups and gender were showed. The values of body capacitive electrical reactance (72.5%) and body phase angle (90.70%) of these patients were below the lower limits of their respective rectangles. These findings were noticeable for patients who had solid tumors.

Conclusions
The BIA is feasible to individualize body bioelectrical parameters and body bioelectric state in newly diagnosed cancer children and how differ from those in apparently healthy subjects, for the same age group and gender. Additionally, the tumor electrical properties may have a noticeable role in changes of body bioelectric-physiological parameters of these newly diagnosed cancer children.
Educational innovation projects in Dutch higher education: bottom-up contextual coping to deal with organizational challenges
Authors: Schophuizen Martine , Kalz Marco 
Published: June 2020

AbstractUnderstanding the process of initiation, design, implementation and embedding of educational innovations in higher education is necessary to develop better strategies for sustainable, large-scale educational innovation. Often early initiated educational innovation projects are not evaluated well enough, making it hard to identify lessons learned. The aim of this study is to investigate how project leaders of innovation projects in Dutch higher education institutions are coping with organizational challenges. To address this we analysed qualitative focus group data with innovators that run projects at Dutch higher education institutions through the lens of contextual coping theory. Results show that the innovators identified challenges (primary appraisal), proposed possible solutions (secondary appraisal) and also were able to take concrete steps (coping efforts) to overcome challenges to design and implement open online educational innovations. From these findings it can be concluded that bottom-up initiatives can create awareness and are capable of finding local resources to establish support for embedding innovations locally, yet, appropriate, synchronized and timely top-down action is needed in order to create a sustainable and institution wide support system for experimentation and embedding of educational innovations. These findings will contribute towards developing better strategies to develop innovative educational practices and quality education.
Real-world questions and concerns about disease-modifying antirheumatic drugs (DMARDs): a retrospective analysis of questions to a medicine call center
Authors: EL Masri Hiba , Hollingworth Samantha A. , van Driel Mieke , Benham Helen , McGuire Treasure M. 
Published: June 2020

AbstractBackgroundDisease-modifying antirheumatic drugs (DMARDs) have transformed the treatment of numerous autoimmune and inflammatory diseases but their perceived risk of harm may be a barrier to use.MethodsIn a retrospective mixed-methods study, we analysed conventional (c) and biologic (b) DMARDs-related calls and compared them with rest of calls (ROC) from consumers to an Australian national medicine call center operated by clinical pharmacists from September 2002 to June 2010. This includes the period where bDMARDs became available on the Pharmaceutical Benefits Scheme, the government-subsidized prescription medicines formulary. We compared caller and patient demographics, enquiry types and motivation to information-seek for both cDMARDs and bDMARDs with ROC, using a t-test for continuous data and a chi-square test for categorical data. We explored call narratives to identify common themes.ResultsThere were 1547 calls involving at least one DMARD. The top three cDMARD enquiry types were side effects (27.2%), interactions (21.9%), and risk versus benefit (11.7%). For bDMARDs, the most common queries involved availability and subsidized access (18%), mechanism and profile (15.8%), and side effects (15.1%). The main consumer motivations to information-seek were largely independent of medicines type and included: inadequate information (44%), wanting a second opinion (23.6%), concern about a worrying symptom (18.8%), conflicting information (6.9%), or information overload (2.3%). Question themes common to conventional and biological DMARDs were caller overemphasis on medication risk and the need for reassurance. Callers seeking information about bDMARDs generally overestimated effectiveness and focused their attention on availability, cost, storage, and medicine handling.ConclusionConsumers have considerable uncertainty regarding DMARDs and may overemphasise risk. Patients cautiously assess the benefits and risks of their DMARDs but when new treatments emerge, they tend to overestimate their effectiveness.
Novel C stain-based chemical method for differentiating real and forged fingerprints
Authors: Saharan Sameer , Yadav A. K. , Yadav Bhuvnesh 
Published: June 2020

Abstract
Background
Fingerprints are useful evidence for establishing identities. Development and detection of fingerprints are of immense help in criminal investigation. However, forged fingerprints identical to the real ones are emerging as a worldwide problem. Existing methods for development of fingerprints (powder method/iodine fuming method/ninhydrin test/AgNO3) fail to distinguish between real and forged fingerprints when forged fingerprints are fortified with salts and amino acids. The present study was conducted with the objective to test applicability of C stain for real and forged fingerprint differentiation.

Methodology
C stain was applied on real and forged fingerprints in combination with conventional methods and was evaluated on the basis of development and differentiation of real and forged fingerprints.

Results
The proposed technique is successful in differentiating between real and forged fingerprints. Colour difference between real and forged fingerprints was observed by taking a combination of C stain with ninhydrin, black powder and iodine fuming, one at a time.

Conclusion
C stain method is an effective technique for distinguishing forged fingerprints from the real ones. It works as a distinction tool even when used in combination with existing development methods.
Assessment of semen characteristics and in vivo conception rate of preserved buffalo bull semen extended in tris enhanced with Diospyros kaki
Authors: El-Sheshtawy Reda Ibrahim , El-Nattat Walid Said 
Published: June 2020

AbstractBackgroundThe freeze-thaw process results in structural and functional damages caused by over accumulation of reactive oxygen species (ROS). Addition of exogenous antioxidants to semen extender is of a great importance to overcome the oxidative damage during the freezing process. The present study aimed to clarify the impact ofDiospyros kakion preserved buffalo semen quality. Tris extender enhanced with kaki juice (KEE) at concentrations 0% (control) and 1-10% (v/v). A twenty percent of freshly prepared egg yolk was added to the KEE extender (KEEY), then all tubes were centrifuged to eliminate any debris. Semen was added to the supernatants in other tubes. Semen was evaluated and the conception rate was implemented.ResultsSperm forward motility was significantly (P <0.0001) kept high after 5 days of chilling for the concentrations 3, 4, and 5% with respect to the control and kept high (P <0.01) at the other concentrations till the 4th day of chilling. Addition of KEE had significantly (P <0.03) ameliorated post freezing sperm motility with all the concentrations of the extender except the concentration (10%). The highest spermatozoal motility was obtained with the concentration of 1% with respect to the control. Alive sperm%, abnormalities%, and % of intact spermatozoa membranes (HOST%) were similar to the control with all concentrations of kaki used. The conception rate was higher when 1-6% KEE were used.ConclusionsSome concentrations of Diospyros kaki improved buffalo bull semen quality post-chilling, post-freezing, the conception rate, and the concentration 1% gave the best results.
Physiological and biochemical role of proline, trehalose, and compost on enhancing salinity tolerance of quinoa plant
Authors: Abdallah Maha Mohamed-Shater , El Sebai Talaat N. , Ramadan Amany Abd El-Mohsen , El-Bassiouny Hala Mohamed Safwat 
Published: June 2020

Abstract
Background and objective
Researches on compost introduced the evidence of its benefits to plant productivity and soil fertility. These advantages are noticed in forms of improving soil water holding capacity and nutrient availability for plants. These changes can also improve plants’ capability to overcome salinity stress conditions. The application of osmo-protectant materials (proline and trehalose) and/or compost addition enhances plant antioxidative defense system against stress conditions. This experiment conducted to study the effect of spraying quinoa plants with proline and trehalose with and without soil compost addition under salinity stress on some morphological and physiological aspects.

Materials and methods
Quinoa plant was grown with or without compost in the soil and foliar sprayed with proline or trehalose under salt irrigation. Plant samples were taken after 60 days from sowing and at the end of the experiment for growth, yield, and biochemical measurements.

Results
Growth and yield measurements were decreased with salinity stress. High levels of both proline and trehalose recorded the highest values of total soluble sugars, proline, and free amino acids in both unstressed or salinity stressed plants with or without compost addition. The use of compost in soil for cultivating quinoa plants with either proline or trehalose treatments increased growth parameters, photosynthetic pigments, and yield attributes. In addition, these treatments improved the accumulation of some organic solutes in leaves and promoted antioxidant enzyme activities.

Conclusion
Compost addition to soil with spraying proline or trehalose improved quinoa growth and yield and produced seed nutritional value.
The diversity of traditional Malay kuih in Malaysia and its potentials
Authors: Kamaruzaman Mohd Yusof Bin , Ab Karim Shahrim , Ishak Farah Adibah Binti Che , Arshad Mohd Mursyid Bin 
Published: June 2020

AbstractMalaysia is synonymously known as a multicultural country flourished with gastronomic nuances in abundance. Within the multitude of well-known savory foods available through the history of Malaysia, kuih has always bestowed a special part in the Malaysian diet. Kuih houses varying types of delicacies ranging from sweets to savory treats or snacks. As with its counterparts in the Malay cuisine, kuih has also been influenced by many historical events led by the migration of Chinese, Indians, and other explorers or visitors to Malaysia in the olden days. This casually developed the Malay kuih which now coined as the traditional Malay kuih; traditional as in the way that the classical values and authenticity were respected and established then. As time progresses and changes the lifestyle of Malays, newly innovated products are at the rise and emerged another type of kuih with somewhat similar characteristics to that of traditional Malay kuih, namely Nyonya Kuih. Nyonya kuih noted to be a reformulation of traditional Malay kuih with native Chinese expertise through some tweaks inculcating their palates and culinary library. Further along, the modernization also impacted the traditional Malay kuih in such a way that the overall representations being put at stake of unclear identity through innovations and industrializations. This paper draws out the history, authenticity, identity, and potentials of the traditional Malay kuih. Besides, this article is hoped to contribute to further refining the traditional Malay food knowledge specifically in its kuih sub-genre against the heritage-destructive modernization led by globalization.
Energy efficiency in Indonesia’s manufacturing industry: a perspective from Log Mean Divisia Index decomposition analysis
Authors: Setyawan Dhani 
Published: June 2020

AbstractThis research discusses energy intensity in Indonesia’s manufacturing sector from 1980 to 2015. The manufacturing sector is the second-largest energy-consumer in Indonesia (after the transportation sector) and one of the largest contributors to Indonesia’s output. Thus, it is important to know the energy usage performance of this sector. This study discusses the factors affecting changes in energy consumption in various subsectors of Indonesia’s industry and investigates the energy intensity across manufacturing subsectors. This paper analyses the specific characteristics of energy intensity in the manufacturing sector in Indonesia from 1980 to 2015. This has not been investigated a great deal in the past, particularly when employing the Log Mean Divisia Index II method.The overall energy intensity of Indonesia’s manufacturing sectors has seen a strong and continuous decline, with a reduction of 65% over the 35 yr, reinforced by some limited changes in industry structure towards lower intensity. Over the entire period, this reduction was dominated by increases in energy efficiency within industries, as indicated by a 62% fall in the within-industry intensive index. By contrast, the effect of moving to a less intensive industry structure was much less important (a 9% fall in the structural index). The greatest rise in energy efficiency within the industry happened before the financial crisis (from 1980 to 97). the shock of the financial crisis saw an unexpected reaction when value-added fell by 13% but energy use remained largely unchanged, implying a rise in energy intensity. From 2000 to 2015 the earlier trends resumed, but at a more subdued pace, where over this period aggregate intensity fell by 23%.