bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Naringin and Zinc Treatment on Biochemical, Molecular, and Histological Alterations in Stomach and Pancreatic Tissues of STZ‐Induced Diabetic Rats
Authors: Abas Al‐Shimaa M. , Sherif Mohamed H. , Ibrahim Sarah 
Published: February 2025

AbstractDiabetes mellitus is a chronic metabolic disorder that affects multiple organs, including the stomach. This research examines the effects of naringin and/or zinc on stomach and pancreatic tissues of streptozotocin‐induced diabetic rats. Type 2 diabetes is induced by intraperitoneal injection of nicotinamide and streptozotocin. Three weeks after diabetes induction, rats receive eight weeks of treatment. Malondialdehyde and total antioxidant capacity are estimated colorimetrically. Asprosin and P‐selectin levels are assessed via ELISA. Quantitative RT‐PCR analysis of nuclear factor kappa B (NF‐кB), peroxisome proliferator‐activated receptor gamma (PPAR γ), and nuclear factor erythroid 2‐related factor 2 (Nrf‐2) genes is carried out. Tumor necrosis factor‐alpha (TNF‐α) is assessed immunohistochemically, and stomach and pancreatic tissues are examined histologically. Combined naringin and zinc treatment significantly reduces gastric Malondialdehyde, serum asprosin, and P‐selectin levels in serum, stomach, and pancreas compared to diabetic rats. Additionally, gastric NF‐кB expression is significantly lower, while PPAR γ and Nrf‐2 expressions are significantly higher compared to diabetic rats. Immunohistochemical analysis and histopathological examination confirm these findings. In conclusion, combined naringin and zinc treatment significantly improves gastric alterations in diabetic rats by reducing oxidative stress and inflammation. Nonetheless, it shows no additional impacts on pancreatic tissue compared to naringin or zinc alone.
KIF11 Inhibition Induces Retinopathy Progression by Affecting Photoreceptor Cell Ciliogenesis and Cell Cycle Regulation in Development
Authors: Xu Yue , Chen Jie , Wang Xin‐Yao , Huang Min‐Hui , Wei Xiang , Luo Xin‐Rui , Wei Ya‐Lan , She Zhen‐Yu 
Published: February 2025

AbstractMicrocephaly with or without chorioretinopathy, lymphedema, or impaired intellectual development (MCLMR; OMIM 152950) is a rare autosomal dominant disorder, which is primarily characterized by defects in the central nervous system and retinal developmental anomalies. Kinesin‐5 KIF11 has been discovered as a major causative gene for MCLMR. It has been well established that KIF11 is essential for microtubule organization, centrosome separation, and spindle assembly during mitosis. However, cellular and molecular mechanisms in the physiopathology of MCLMR remain largely unknown. In this study, KIF11‐inhibition mouse models are generated, which reveal that chemical inhibition of KIF11 results in defects in retinal development, the formation of rosettes, photoreceptor ciliary alterations, and vision loss. Furthermore, it is demonstrated that KIF11 is essential for the formation, organization, and maintenance of primary cilia in photoreceptor cells, which further contributes to the organization of photoreceptor cells and the development of the retina. Using the developing mouse embryos as a model, it is revealed that KIF11 inhibition induces the formation of monopolar spindle and mitotic arrest, which further results in tetraploidy and apoptotic cell death. These findings uncover cellular mechanisms underlying the loss‐of‐function of KIF11 and retinopathy in MCLMR and further support the functions of KIF11 in development.
Discovery of a Resonant High‐Level Reverse Intersystem Crossing of Hot Exciton from Conventional TTPA Fluorescent Semiconductor and an Attempt on High‐Efficiency TTPA‐Based OLEDs
Authors: Liu Junhong , Chen Jing , Wang Jingjing , Peng Teng , Wang Bo , Zhou Yinqiong , Zhang Keyi , Yang Jun , Chen Feng , Li Yuanjun , Li Qiang , Guo Jinfeng , Chen Xiaoli , Xiong Zuhong 
Published: February 2025

AbstractAlthough high‐efficiency 9,10‐bis[N,N‐di‐(p‐tolyl)‐amino]anthracene (TTPA)‐based organic light‐emitting diodes (OLEDs) are widely reported, their physical origins of excited states in TTPA are still vague. Herein, using the fingerprint magneto‐electroluminescence probing tool, a resonant high‐level reverse intersystem‐crossing (HL‐RISC, S1, TTPA ← T2, TTPA) of hot‐excitons is discovered from the conventional fluorescent TTPA semiconductor whose triplet exciton states are generally ignored in the previous literature. This fascinating HL‐RISC channel is well validated by the optical, electric, and magnetic properties of the undoped TTPA‐based OLEDs. For TTPA‐doped OLEDs, this channel can efficiently occur when triplet energies of the host and the exciton blocking layer are higher than that of T2, TTPA. More importantly, an external quantum efficiency (EQE) as high as 10.14% is achieved from the simple emission layer without using any phosphorescent sensitizer, i.e., just by doping the TTPA emitter into the DMAC‐DPS host with thermally activated delayed fluorescence property. This high EQE is attributed to fully harvesting singlet and triplet excitons of the device via the simultaneous utilization of the newly‐found HL‐RISC from TTPA guest and the low‐level RISC from DMAC‐DPS host. Accordingly, this work paves a novel pathway for designing high‐performance fully fluorescent OLEDs with inherent device stability and low‐cost superiority.
Delivery of A Chemically Modified Noncoding RNA Domain Improves Dystrophic Myotube Function
Authors: Niasse‐Sy Zeinabou , Zhao Bo , Lenardič Ajda , Luong Huyen Thuc Tran , Bar‐Nur Ori , Auwerx Johan , Wohlwend Martin 
Published: February 2025

AbstractFast twitch muscle fibers are prone to degradation in skeletal muscle pathologies, such as sarcopenia and muscular dystrophies. We previously showed that the exercise‐induced long noncoding RNA CYTOR promotes fast‐twitch myogenesis. Here, we identify an independent functional element within human CYTOR, and optimize its RNA delivery. In human primary myoblasts exogenous CYTOR exon 2 recapitulates the effect of full‐length CYTOR by boosting fast‐twitch myogenic differentiation. Furthermore, chemically modified CYTORexon2 RNAΨU (N1‐me‐PseudoU, 7‐methyl guanosine 5′Cap, polyA) enhances RNA stability and reduces immunogenicity to CYTORexon2 RNA. Viral‐ or chemically optimized RNA‐mediated CYTORexon2 administration drives commitment toward myogenic maturation in Duchenne muscular dystrophy‐derived primary myoblasts, myogenic progenitor cells, and mouse embryonic stem cells. Furthermore, CYTORexon2,ΨU improves key disease characteristics in dystrophic myotubes, including calcium handling and mitochondrial bioenergetics. In summary, we identify CYTOR exon 2 as the functional domain of CYTOR that can be delivered in a disease context using chemical modifications. This is of particular importance given the susceptibility of fast muscle fibers in different muscle pathologies such as aging and dystrophies, and the oncogenic effect of CYTOR exon 1. This study, therefore, highlights the potential of identifying functional domains in noncoding RNAs. Delivery, or targeting of RNA domains might constitute next‐generation RNA therapeutics.
Beyond the Extra X and Y Chromosome: The Contribution of Familial Risk for Psychopathology to the Neurodevelopmental Phenotype of Children With Sex Chromosome Trisomy
Authors: van Rijn Sophie , Kuiper Kimberly , Swaab Hanna 
Published: February 2025

ABSTRACTIndividuals with an extra X or Y chromosome (sex chromosome trisomy or SCT) have an increased risk for symptoms of psychopathology and neurocognitive dysfunction. In this study, we evaluated the contribution of family history (FH) of neuropsychiatric or neurocognitive disorders to the phenotype of SCT. One hundred and six children with SCT and 102 nonclinical controls, all aged 1–7 years, and their primary caregiver (parent) participated. Rates of neuropsychiatric and neurocognitive disorders were collected for all first‐degree family members of the children. Neurocognitive tests and parental questionnaires were used to evaluate children's neurobehavioral and neurocognitive phenotypes. Results showed no systematic differences in FH of neuropsychiatric and neurocognitive disorders between the SCT and control groups. No significant effect of a FH of psychiatric disorders was found on any of the child outcomes. FH of neurocognitive disorders had a single significant effect on child outcomes. Inattention problems in SCT were higher with a positive FH of neurocognitive disorders, showing dosage response effects. Familial factors may only minimally contribute to the overall phenotype of SCT on group level, although a positive FH of neurocognitive disorders may contribute to ADHD inattention symptoms in children with SCT, beyond the risk associated with the extra X or Y chromosome.
Description of unilateral kidney embolism and contralateral nephrectomy as a less invasive remnant kidney model in cats; a proof‐of‐concept study
Authors: Schmiedt Chad W. , Lourenço Bianca N. , Markovic Lauren E. , Lancaster Meghan , Gumber Sanjeev , Wannemacher Juliane , Florian Peter , Coleman Amanda E. 
Published: February 2025

AbstractBackgroundRefined models of kidney disease are critical to better understand disease processes and study novel treatments while minimizing discomfort in research animals. The objective of this study was to report a technique for minimally invasive partial kidney embolism in cats and describe outcomes following transcatheter administration of embolic microspheres with subsequent contralateral nephrectomy.MethodsEleven, apparently healthy, male, purpose‐bred cats underwent unilateral kidney embolism with 0.25 or 0.5 mL of embolic microparticle (40–120 μm) suspension (0.2 mL microspheres/mL) delivered into the right renal artery under fluoroscopic guidance, followed 5 months later by contralateral nephrectomy. One month after nephrectomy, blood and urinary markers of kidney function were evaluated, and embolized kidneys were harvested for histopathology evaluation.ResultsRenal artery embolization was possible in all cats. Two cats did not complete the study, one after experiencing congestive heart failure (n = 1) and the other following evidence of complete kidney embolism precluding nephrectomy (n = 1) post‐embolization. At study end, compared to baseline, cats had significant increases in median (range) serum creatinine (159.1 μmol/L [141.4–530.4] versus 128.2 μmol/L [92.8–150.3]; p = 0.0004), urea nitrogen (15.71 mmol/L [9.29–47.85] versus 7.50 mmol/L [6.07–8.57]; p < 0.0001), and symmetric dimethylarginine (0.74 μmol/L [0.59–3.12] versus 0.67 μmol/L [0.54–0.72]; p = 0.0288) concentrations. No differences in markers of kidney function were documented between dose groups.ConclusionsMinimally invasive kidney embolism is a promising technique for modeling kidney disease in cats. Understanding optimal dose, timing of nephrectomy, and longer‐term consequences requires additional work.
Quantum Mechanical Tunnelling Probes with Redox Cycling for Ultra‐Sensitive Detection of Biomolecules
Authors: Yi Long , Jiang Tao , Ren Ren , Cao Ji , Edel Joshua B. , Ivanov Aleksandar P. , Tang Longhua 
Published: February 2025

Quantum mechanical tunnelling sensors (QMTs) have emerged as a promising technology for next‐generation single‐molecule detection. When QMT sensors are combined with redox species, repeated oxidation and reduction (redox cycling) can also be observed. We developed robust QMT probes with electrode gap distances below 2 nm. Using the generator‐collector (GC) mode, we verified that redox cycling of the ferrocyanide/ferricyanide (Fe(CN)63‐/4‐) couple occurs both in the tunnelling regime and on the electrode surface. Our findings indicated that the current enhancement is affected by both the gap distance and surface modifications of the probes. These QMT probes exhibited remarkable sensitivity, capable of detecting Fe(CN)63‐/4‐ concentrations as low as sub‐picomolar levels. Utilising this ability to modulate redox reactions, we adapted the QMT probes to serve as electrochemical sensors for detecting viral proteins. By modifying the electrode surfaces, our functionalised QMT probes achieved sub‐pM detection limits with high selectivity in biofluids such as nasopharyngeal secretions. These findings highlight the potential of QMT probes to develop into a new class of electrochemical tunnelling sensors, offering significant advancements in biomedical diagnostics.
Highly Efficient Ag/Fe3O4@MWCNTs MNCs Catalyzed Green Synthesis of New Derivatives of 1,2,4‐Triazine: The Cytotoxic Activity Investigation of 1,2,4‐Triazines
Authors: Iravani Nasir , Barani Khatereh Khandan , Moradian Majid , Hossaini Zinatossadat 
Published: February 2025

ABSTRACTThis study synthesized 1,2,4‐triazines, a novel class of derivatives, with a high efficiency using a multicomponent reaction. The reaction involved oxoindolinylidene malononitrile, ethyl 2‐arylamino‐4‐dioxo‐4‐arylbutanoates, and hydrazonoyl chlorides in an aqueous solution at room temperature. The reaction was facilitated by the presence of Ag/Fe3O4@MWCNTs MNCs. This study examines the antioxidant properties of 1,2,4‐triazine in addition to the other research undertaken in this work. Using the MTT test, the cytotoxic properties of all the produced compounds were assessed in vitro against cancer cell lines (MCF‐7 and A549) and normal cell lines (BEAS‐2B). It was discovered that the most effective cytotoxic agent, doxorubicin like in its lack of selectivity, was Derivative 4e. On the other hand, Compound 4b might be regarded as an equipotent molecule with greater selectivity in relation to doxorubicin. The production process of 1,2,4‐triazine demonstrated several advantageous features, including rapid reactions, high yields of the final product, and straightforward separation of the catalyst and product from the reaction mixture.
Research on autonomous decision‐making method for spacecraft in the mission of rendezvous and approaching to maneuvering target based on deep reinforcement learning
Authors: Huang Cheng , Xing Aijia , Zeng Quanli , Xiong Fangyu 
Published: February 2025

AbstractIn this paper, an autonomous decision‐making method for close‐range rendezvous and approaching to noncooperative target with strong maneuvering is proposed based on the distributed distributional deep determined policy gradient (D4PG), and ground simulation system of rendezvous and approaching is constructed by the improved YOLOv5s and universal robotic arm to verify the effectiveness and feasibility. The contributions of this paper are as follows: (1) an improved nearest neighbor exploration mechanism including random constant value and logarithmic constant value is proposed to stabilize the convergence for the decision‐making under the uncertainty; (2) a discrete wavelet transform (DWT)‐based preprocessing, a fusion of generalized additive model (GAM), and an optimization scheme are proposed for the dark background and false detection of black objects; and (3) a comparison analysis of simulation result between the traditional noise and proposed state‐based exploration is presented for the superiority and some robot‐based ground experiments are done to verify feasibility of close‐range space rendezvous and approaching.
Reduced Modulation of Theta and Beta Oscillations Mediates Empathy Impairment in Parkinson's Disease
Authors: Han Jinying , Yu Liuzhenxiong , Wang Mengqi , Chen Xin , Zhao Ziye , Liu Pingping , Hu Lili , Lv Lingling , Xing Fengbo , Cao Ruihua , Ye Rong , Wang Kai , Hu Panpan 
Published: February 2025

ABSTRACTBackgroundEmpathy is an inaccessible part of advanced social cognitive functions in humans. Impairment of empathy greatly affects the quality of life of patients with Parkinson's disease (PD) but the underlying neurophysiologic mechanisms have not been established.ObjectivesThe dynamic process of brain oscillations in PD pain empathy was explored and the mechanism of empathy damage was studied.MethodsA total of 27 patients with PD and 13 healthy controls were recruited to undergo a pain judgment task, and the event‐related potentials were recorded. This study compared the changes in theta and beta oscillations among two groups after the presentation of painful and neutral stimuli.ResultsTime–frequency analysis results revealed that patients with PD exhibited event‐related theta oscillation synchronization and beta oscillation desynchronization during pain empathy. Compared to healthy controls, patients with PD exhibited a reduced magnitude of beta oscillation desynchronization in response to painful stimuli and attenuated synchronization of theta oscillations induced by neutral stimuli. There are abnormal beta power differences between painful and neutral stimuli, while no differences were found in theta power in PD. Moreover, a positive correlation existed between the degree of beta oscillation desynchronization associated with painful stimuli and the accuracy of pain judgments.ConclusionPain empathy deficits in PD were associated with reduced dynamic modulation of brain theta and beta oscillations.
Associations Between Elevated Rates of Depression, Anxiety, and PTSD Among ICU Survivors and Increased Mortality and Readmissions
Authors: Chang Chen‐Shu , Tsai Fuu‐Jen , Liao Chun‐Hui 
Published: February 2025

ABSTRACTPurposeIntensive care unit (ICU) mortality has decreased, highlighting improved patient outcomes. However, other critical factors affect post‐ICU survival, including lasting physical, cognitive, and psychological challenges termed postintensive care syndrome (PICS), encompassing depression, anxiety, and posttraumatic stress disorder (PTSD). The prevalence of these conditions among ICU survivors is high and potentially linked to ICU treatment. This study aims to understand these factors using Taiwan's National Health Insurance Research Database (NHIRD), exploring their impact on mortality and readmission rates post‐ICU discharge.MethodsThe National Health Insurance (NHI) program in Taiwan, implemented in 1995, provides healthcare for nearly all residents. Its research arm, NHIRD, contains comprehensive medical data for nationwide studies. This research focuses on ICU patients with specific conditions from 2010 to 2018, using ICD codes for diagnosis. Statistical analyses include Cox proportional hazard models and logistic regression, aiming to assess the incidence and risks of anxiety/depression/PTSD.ResultsICU patients showed a higher risk of anxiety/depression/PTSD compared to non‐ICU patients (adjusted HR = 1.17), with similar trends for anxiety and depression. Females, younger patients, those with higher CCI scores, on mechanical ventilators, and more extended hospital stays had increased odds of anxiety/depression/PTSD. ICU patients with anxiety/depression/PTSD faced increased risks of death and re‐admission, especially among older males with comorbidities.ConclusionThis study discovered higher anxiety and depression rates post‐ICU compared to general ward patients, particularly among younger individuals, females, and those with longer hospital stays. Factors such as higher comorbidity scores and mechanical ventilation use were linked to lower odds. Addressing mental health postdischarge is crucial, especially for at‐risk groups.
To Explore the Relationship Between Sustainability, Digital Technology, and Sustainable Development Goals
Authors: Saha Aditi , Raut Rakesh , Kumar Mukesh , Ghoshal Sudishna 
Published: February 2025

ABSTRACTIn the era of rapid technological advancement and growing global challenges, the interaction between sustainability, digital technology (DT), and sustainable development goals (SDGs) presents a vital opportunity for transformative action. This convergence opens doors to innovative solutions for addressing critical environmental and societal issues while advancing economic progress. Therefore, this study aims to explore the intricate relationship between sustainability, digital technology, and SDGs. A systematic literature review and Preferred Reporting Items for Systematic Review and Meta‐Analyses (PRISMA) protocol have been used to comprehend the impact of DT on promoting SDGs across diverse sectors while enhancing sustainability. By analyzing the 141 articles, it could be concluded that achieving sustainability by adhering to the SDGs requires effective integration of DT and a thorough understanding of the policy reforms and SDG knowledge that support both sustainability goals and digitalization. The findings also indicate that achieving the SDGs in the era of digitalization relies on the collective and collaborative ability to leverage digital technology as a crucial tool and resource for positive transformation while mitigating its adverse impacts. Furthermore, the successful integration of DT with SDGs requires a comprehensive approach that encompasses technological innovation, a supportive governance framework, and capacity building.
Avoiding Harm by Doing Good. The Substantive Role of ESG Payments for Preventing ESG Misconduct
Authors: García‐Meca Emma , Martínez‐Ferrero Jennifer , Hussain Nazim 
Published: February 2025

ABSTRACTThis paper examines whether an ESG‐based compensation policy plays a substantive or symbolic role in the prevention of firm ESG‐related misconduct. We anticipate that companies linking ESG to board compensation will experience fewer ESG‐related misconducts, aiming to avoid adverse consequences, mitigate market reactions, and minimize harm to stakeholders. We also expect that institutional ownership strengthens this relationship. By analyzing a sample of European firms between 2015 and 2020, we found that boards with an ESG‐linked compensation policy reduce irresponsible actions, confirming the substantive role of ESG‐linked compensation in curbing ESG misconduct. Our findings also show a complementary effect of institutional investors in this association. Finally, we found that variations in negative ESG media coverage of misconducts that result from undertaking ESG‐linked compensation policy can be explained by differences in legal systems and stakeholder orientation between countries. Specifically, our results suggest that ESG‐linked compensation only plays a meaningful substantive role in constraining ESG wrongdoing in civil law countries and those characterized by greater public enforcement, increased control over corruption, and higher environmental awareness.
Advancing Bipolar Electrochemistry for Targeted Deposition of Biocompatible Polymers in Electrolyte‐Free Solutions via Finite Element Modeling
Authors: Wagner Michal , Brady Áine , Doyle Oisín F. , Forster Robert J. 
Published: February 2025

AbstractThe spatially controlled, template‐free, deposition of electroactive and biocompatible materials on 3D objects is of great interest for wireless cell stimulation intended for diverse applications ranging from electroceuticals to advanced sensor development. Bipolar electrochemistry provides the possibility of depositing electrically conducting polymers controlled through the (shaped) electric field distribution. A second advantage is that electrochemistry can be performed in electrolyte‐free media potentially removing the “interfering” effect of added electrolyte. Here, poly(3,4‐ethylenedioxythiophene) (PEDOT) films have been deposited on bipolar electrodes directly in ultrapure water. Significantly, the deposition patterns cannot be fully explained using a linear change in the solution‐phase potential, which is a common assumption for bipolar electrochemical systems. 3D finite element modeling and diffusive mass transport considerations have been combined to map the electric field distribution in this very low conductivity medium and demonstrate that homogenous rather than heterogeneous electron transfer is likely to play an important role in polymer deposition. Moreover, modeling predictions were compared to electrochemical impedance and cyclic voltammetry results and non‐linear behaviours qualitatively matched, through film capacitances, and deposition patterns. The proposed framework opens up significant opportunities for the template‐free deposition of various electroactive materials on bipolar electrodes in low‐conductivity solutions.