bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beam manipulations with barrier buckets in the CERN PS
Authors: Vadai M , Alomainy A , Damerau H , Gilardoni S , Giovannozzi M , Huschauer A 
Published: December 2019

Abstract
A barrier bucket scheme is being considered to reduce losses during the Multi-Turn Extraction from the CERN Proton Synchrotron to the Super Proton Synchrotron for the fixed- target physics programme. For effective loss reduction, the extraction kicker has to be triggered during the gap at the time of the longitudinal barrier. Initial beam studies at injection energy and with low intensity beams allowed to fully qualify an existing wide-band cavity to generate one or multiple beam synchronous pulses per turn. Bunch-length stretching and shortening have been exercised with barriers moving in azimuth with respect to the beam. The encouraging results obtained at injection energy guided the implementation of a de-bunching manipulation at higher energy to move all bunches into a single barrier bucket. Beam measurements at a momentum of 14GeV/c, varying intensity and the width of the barrier, demonstrate that a quasi-constant longitudinal line density and an almost fully depleted gap can be achieved at highest intensities. The contribution summarises the results of the beam studies at high energy together with some observations related to the Multi-Turn Extraction.
Hardware Commissioning of the Refurbished ALPI Linac at INFN-LNL to Serve as SPES Exotic Beam Accelerator
Authors: Bisoffi G , Bellan L , Bellato M , Borille D , Bortolato D , Carletto O , Chiurlotto F , Comunian M , Conte A , Contran T , De Lazzari M , Fagotti E , Giacchini M G , Lollo M , Marcato D , Miglioranza M O , Modanese P , Moisio MF , Montis M , Munaron E , Nigrelli G , Pavinato S , Pengo M , Pisent A , Poggi M , Pranovi L , Roncolato C , Rossignoli M , Scarpa D 
Published: December 2019

Abstract
The ALPI linac at INFN-LNL was substantially refurbished in 2018, especially in view of its use as secondary accelerator for exotic species in the framework of the SPES project. In particular: 10 magnetic triplets were replaced with higher gradient ones; two cryomodules with quarter wave resonator were moved from the PIAVE injector to ALPI, so as to make them available both for exotic and stable beams; the cryogenic plant was renovated; the whole linac, its injector and its beam lines were eventually realigned via LASER tracking (LT). The expected outcome of the refurbishment project is a larger beam transmission (crucial for the efficient transport of the unavoidably low current exotic beams) and improved overall reliability so as to further extend the lifetime of an already 25 years old machine. The hardware commissioning of this new configuration will be reported.
Commissioning Results of the Tertiary Beam Lines for the CERN Neutrino Platform Project
Authors: Booth A. , Charitonidis N. , Chatzidaki P. , Karyotakis Y. , Nowak E. , Ortega Ruiz I. , Rosenthal M. , Sala P. 
Published: December 2019

Abstract
For many decades the CERN North Area facility at the Super Proton Synchrotron (SPS) has delivered secondary beams to various fixed target experiments and test beams. In 2018, two new tertiary extensions of the existing beam lines, designated “H2-VLE” and “H4-VLE”, have been constructed and successfully commissioned. These beam lines have been designed to provide charged particles of both polarities in the momentum range from 0.3GeV/c to 12GeV/c. During the design phase, multiple simulation tools and techniques have been employed to optimize the tertiary beam line layout in terms of particle production, transverse beam dynamics and particle identification on an event-by-event basis. In this paper, a comparison of the simulated performance and the first measurement results obtained during the commissioning phase are presented.
SPIRAL2 RFQ bunch lengths and longitudinal emittance measurements
Authors: Normand G. , Di Giacomo M. , Ferdinand R. , Kamalou O. , Lagniel JM. , Savalle A. , Uriot D. 
Published: December 2019

Abstract
The SPIRAL2 beam commissioning has started and the superconducting linac installation is being finalized. The conditioning of the Radio Frequency Quadrupole (RFQ) [1] begun in 2015, and the beam commissioning soon after. Among the beam parameters checked at the RFQ output, the energy, bunch length and longitudinal emittance have been measured for the 3 referenced particles.
Extraction System of Upgraded AVF Cyclotron of RCNP
Authors: Nakao M , Fukuda M , Hara S , Hara T , Hatanaka K , Kamakura K , Kanda H , Koay H W , Morinobu S , Morita Y , Nagayama K , Saito T , Takeda K , Tamura H , Yasuda Y , Yorita T 
Published: December 2019

Abstract
At the Research Center for Nuclear Physics (RCNP) of Osaka University, the demand for both high-intensity and high-quality beam has been increasing. New injection, acceleration, and extraction system of the AVF cyclotron are under development to meet the demand. Extraction system was designed to increase the extraction efficiency since beam loss at electrodes or apertures makes unacceptable radio activation of apparatus when the beam intensity increased. Simulation study confirmed that 10 MeV protons, 65 MeV protons and 140 MeV 4He2+ particles with emittance of 2 mm × 3 mrad can pass through the newly designed extraction system and the existing beam transport line.
Beam Dynamics And Diagnostics For The High Energy Beam Transport Line of Minerva Project At Sck-Cen
Authors: Kraft H. , Perrot L. 
Published: December 2019

Abstract
MYRRHA will be a research infrastructure highlighted by the first prototype of a sub-critical nuclear reactor driven by a 600 MeV particle accelerator (ADS). This project aims at exploring the transmutation of long-lived nuclear wastes. A first phase is planned to validate the reliability of a 100 MeV/4 mA Protons LINAC carrying the beam toward an ISOL facility, prefiguring the real MYRRHA demonstrator at 600 MeV [1]. This project is called MINERVA [2]. This paper presents the status of the beam dynamic studies for the high energy beam transport lines at 100 MeV. In agreement with the project requirements, we describe the specificities of these beam lines for which it is needed to implement a fast kicker-septum. This system will separate the beam between two main lines: toward the beam dump or the ISOL facility [3]. We also describe the studies on the Beam Position Monitor (BPM) selected for MYRRHA. Part of this work was support by the MYRTE project of the European Union [4].
Residual orbits estimation of the injection painting bumps for CSNS
Authors: Huang Ming-Yang , Wang Sheng , Xu Shou-Yan 
Published: December 2019

Abstract
There are three bumps (one chicane bump and two painting bumps) in the injection system of the China Spallation Neutron Source (CSNS). They are the core parts of the injection system and the important guarantee that the Linac beam injecting into the rapid cycling synchrotron (RCS). During the beam commissioning, to check the effect of the residual orbits of the three bumps in the injection region was an important problem. In this paper, the residual orbits of BH and BV painting bumps were studied and estimated in the beam commissioning. The data analysis results showed that the residual orbits of BH and BV painting bumps were very small and they didn't need to be corrected.
Field-Map And Beam Transport Calculations of The Magnetic Separator At Alto Facility At Orsay
Authors: Perrot L , Ollier R 
Published: December 2019

Abstract
The Institute of Nuclear Physics at Orsay (IPNO) has always been a major player in building accelerators for nuclear physics. The Accelerator Linear Tandem Orsay (ALTO) facility is powered by a 50 MeV/10uA linear electron accelerator dedicated to the production of radioactive beams [1]. The production mode is based on the photo-fission process of a thick UCx target heated up to 2000°C and using the Isotopes Separation On-Line (ISOL) technique [2]. For the ionization of the released fission fragments, three ion source types can be coupled to the target: a Febiad ion source, surface ion source, and laser ion source. The facility can deliver the radioactive ions beams (RIB) to six different experimental setups. The mass of the produced mono-charged Radioactive Ions Beam is selected using a magnetic dipole in order to select a nucleus before its transmission through electrostatic devices up to the experimental setups [3]. This paper is focused on the separator that was built and exploited with success since 43 years. The separator is located closely to the exit of the source of RIB production. We propose to revisit this dipole with a precise field-map calculation and particles transport simulations. These results will be used as a first brick for the understanding and reliability of the transmission along the RIB lines at the ALTO facility.
An algorithm for automated lattice design of transfer lines
Authors: Reimann S , Droba M , Meusel O , Podlech H 
Published: December 2019

Abstract
Since the last 20 years, modern heuristic algorithms and machine learning have been increasingly used for several purposes in accelerator technology and physics. Since computing power has become less and less of a limiting factor, these tools have become part of the physicist community’s standard toolkit [1][2] [3] [4] [5]. This paper describes the construction of an algorithm that can be used to generate an optimised lattice design for transfer lines under the consideration of restrictions that usually limit design options in reality. The developed algorithm has been applied to the existing SIS18 to HADES transfer line in GSI.
Minimising the loss of biodiversity and ecosystem services in an intact landscape under risk of rapid agricultural development
Authors: Williams Brooke A , Grantham Hedley S , Watson James E M , Alvarez Silvia J , Simmonds Jeremy S , Rogéliz Carlos A , Da Silva Mayesse , Forero-Medina Germán , Etter Andrés , Nogales Jonathan , Walschburger Tomas , Hyman Glenn , Beyer Hawthorne L 
Published: December 2019

Abstract
As humanity’s demand for resources continues to rise and productive arable lands become increasingly scarce, many of Earth’s remaining intact regions are at heightened risk of destruction from agricultural development. In situations where agricultural expansion is inevitable, it is important to manage intact landscape transformation so that impacts on environmental values are minimised. Here, we present a novel, spatially explicit, land use planning framework that addresses the decision making needed to account for different, competing economic-environment objectives (agricultural production value, biodiversity conservation, ecosystem service retention) when land use change is inevitable within an intact landscape. We apply our framework to the globally significant savannahs of the Orinoquia (Colombia), which in a post-conflict era is under increased agricultural development pressure. We show that while negative environmental impacts can be reduced through planning, the total area of land converted to agriculture is the unavoidable principal driver of biodiversity and ecosystem service loss. We therefore identify planning solutions that perform well across all objectives simultaneously, despite trade-offs among them. When 15%, 20%, 30% and 40% of the study area is allowed to be converted to agriculture, on average planning can improve species persistence and ecosystem service retention by up to 16%, 15%, 12%, and 9%, respectively, when compared to agricultural-focused solutions. Development in the region so far has had an unnecessarily large impact on environmental objectives due to a lack of effective land use planning, creating an ‘opportunity debt’. Our study provides an evidence base to inform proactive planning and the development of environmentally sensible agricultural development policy and practice in the region. This framework can be used by stakeholders to achieve agriculture expansion goals and maximise economic profit while minimising impacts on the environment in the Orinoquia, or any relatively intact region that is being developed.
Recent advances in modeling organic electrochemical transistors
Authors: Colucci Renan , Barbosa Henrique Frulani de Paula , Günther Florian , Cavassin Priscila , Faria Gregório Couto 
Published: December 2019

Abstract
Organic electrochemical transistors (OECTs) have been successfully used as transducers in applications requiring the conversion of ion fluxes to electronic current. These applications range from regular biosensors to sophisticated devices for neuron recording and stimulation. For the rational optimization and understanding of the fundamentals of OECTs and OECT-based applications, however, it is essential to develop in-depth theoretical predictions of experimental data. Here, we review seminal works on modeling both the steady state and transient behavior of OECTs and discuss their strengths and weaknesses. Given that OECTs have been used and applied by a diverse community with very different backgrounds, our intention is to clarify and to extend most of the theoretical developments established so far. Special attention is given to the early models, while trying to make them accessible for everyone in the field of organic bioelectronics.
Quantitative Three-Dimensional Reconstructions of Excitatory Synaptic Boutons in the “Barrel Field” of the Adult “Reeler” Mouse Somatosensory Neocortex: A Comparative Fine-Scale Electron Microscopic Analysis with the Wild Type Mouse
Authors: Prume Miriam , Rollenhagen Astrid , Yakoubi Rachida , Sätzler Kurt , Lübke Joachim Hr 
Published: December 2019

AbstractSynapses are key structural determinants for information processing and computations in the normal and pathologically altered brain. Here, the quantitative morphology of excitatory synaptic boutons in the “reeler” mutant, a model system for various neurological disorders, was investigated and compared with wild-type (WT) mice using high-resolution, fine-scale electron microscopy (EM) and quantitative three-dimensional (3D) models of synaptic boutons. Beside their overall geometry, the shape and size of presynaptic active zones (PreAZs) and postsynaptic densities (PSDs) forming the active zones and the three pools of synaptic vesicles (SVs), namely the readily releasable pool (RRP), the recycling pool (RP), and the resting pool, were quantified. Although the reeler mouse neocortex is severely disturbed, no significant differences were found in most of the structural parameters investigated: the size of boutons (~3 μm2), size of the PreAZs and PSDs (~0.17 μm2), total number of SVs, and SVs within a perimeter (p) of 10 nm and p20 nm RRP; the p60 nm, p100 nm, and p60–p200 nm RP; and the resting pool, except the synaptic cleft width. Taken together, the synaptic organization and structural composition of synaptic boutons in the reeler neocortex remain comparably “normal” and may thus contribute to a “correct” wiring of neurons within the reeler cortical network.
Mas receptor is translocated to the nucleus upon agonist stimulation in brainstem neurons from spontaneously hypertensive rats but not normotensive rats
Authors: Cerniello Flavia M , Silva Mauro G , Carretero Oscar A , Gironacci Mariela M 
Published: December 2019

Abstract

Aims
Activation of the angiotensin (Ang)-(1-7)/Mas receptor (R) axis protects from sympathetic overactivity. Endocytic trafficking is an essential process that regulates receptor (R) function and its ultimate cellular responses. We investigated whether the blunted responses to Ang-(1-7) in hypertensive rats are associated to an alteration in MasR trafficking.

Methods and results
Brainstem neurons from Wistar-Kyoto (WKY) or spontaneously hypertensive rats (SHRs) were investigated for (i) Ang-(1-7) levels and binding and MasR expression, (ii) Ang-(1-7) responses (arachidonic acid and nitric oxide release and Akt and ERK1/2 phosphorylation), and (iii) MasR trafficking. Ang-(1-7) was determined by radioimmunoassay. MasR expression and functionality were evaluated by western blot and binding assays. MasR trafficking was evaluated by immunofluorescence. Ang-(1-7) treatment induced an increase in nitric oxide and arachidonic acid release and ERK1/2 and Akt phosphorylation in WKY neurons but did not have an effect in SHR neurons. Although SHR neurons showed greater MasR expression, Ang-(1-7)-elicited responses were substantially diminished presumably due to decreased Ang-(1-7) endogenous levels concomitant with impaired binding to its receptor. Through immunocolocalization studies, we evidenced that upon Ang-(1-7) stimulation MasRs were internalized through clathrin-coated pits and caveolae into early endosomes and slowly recycled back to the plasma membrane. However, the fraction of internalized MasRs into early endosomes was larger and the fraction of MasRs recycled back to the plasma membrane was smaller in SHR than in WKY neurons. Surprisingly, in SHR neurons but not in WKY neurons, Ang-(1-7) induced MasR translocation to the nucleus. Nuclear MasR expression and Ang-(1-7) levels were significantly greater in the nuclei of Ang-(1-7)-stimulated SHR neurons, indicating that the MasR is translocated with its ligand bound to it.

Conclusion
MasRs display differential trafficking in brainstem neurons from SHRs, which may contribute to the impaired responses to Ang-(1-7).
Pseudo-chromosome–length genome assembly of a double haploid “Bartlett” pear (Pyrus communis L.)
Authors: Linsmith Gareth , Rombauts Stephane , Montanari Sara , Deng Cecilia H , Celton Jean-Marc , Guérif Philippe , Liu Chang , Lohaus Rolf , Zurn Jason D , Cestaro Alessandro , Bassil Nahla V , Bakker Linda V , Schijlen Elio , Gardiner Susan E , Lespinasse Yves , Durel Charles-Eric , Velasco Riccardo , Neale David B , Chagné David , Van de Peer Yves , Troggio Michela , Bianco Luca 
Published: December 2019

Abstract

Background
We report an improved assembly and scaffolding of the European pear (Pyrus communis L.) genome (referred to as BartlettDHv2.0), obtained using a combination of Pacific Biosciences RSII long-read sequencing, Bionano optical mapping, chromatin interaction capture (Hi-C), and genetic mapping. The sample selected for sequencing is a double haploid derived from the same “Bartlett” reference pear that was previously sequenced. Sequencing of di-haploid plants makes assembly more tractable in highly heterozygous species such as P. communis.

Findings
A total of 496.9 Mb corresponding to 97% of the estimated genome size were assembled into 494 scaffolds. Hi-C data and a high-density genetic map allowed us to anchor and orient 87% of the sequence on the 17 pear chromosomes. Approximately 50% (247 Mb) of the genome consists of repetitive sequences. Gene annotation confirmed the presence of 37,445 protein-coding genes, which is 13% fewer than previously predicted.

Conclusions
We showed that the use of a doubled-haploid plant is an effective solution to the problems presented by high levels of heterozygosity and duplication for the generation of high-quality genome assemblies. We present a high-quality chromosome-scale assembly of the European pear Pyrus communis and demostrate its high degree of synteny with the genomes of Malus x Domestica and Pyrus x bretschneideri.
Decolonial Sketches and Intercultural Approaches to Truth: Corporeal Experiences and Testimonies of Indigenous Women in Colombia
Authors: Santamaría Angela , Muelas Dunen , Caceres Paula , Kuetguaje Wendi , Villegas Julian 
Published: December 2019

Abstract
This article explores the corporeal and testimonial memories of a group of female indigenous ex-combatants and victims in the Colombian Caribbean and Amazon. Although these groups have often been analyzed in the transitional justice literature, our primary objective is to analyze two local processes for retrieving indigenous women’s memories and possible feminist participatory action research methodologies in the Colombian postconflict context. We examined empowering intercultural and intersectional methodologies to promote the political participation of indigenous women – both ‘victims’ and ‘perpetrators’ – in the Colombian Truth Commission implemented after the peace agreement was enacted. We explain how participatory action research should be used, including techniques such as indigenous women’s body mapping, creating testimonial spaces and conducting ethnographic observations. The article is based on a transitional justice ‘from below’ perspective as well as local transitional justice practices.
Development and Utility of the Observational Research in Oncology Toolbox: Cancer Medications Enquiry Database-Healthcare Common Procedure Coding System (HCPCS)
Authors: Rivera Donna R , Lam Clara J K , Enewold Lindsey , Petkov Valentina I , Tran Quyen , Brennan Sean , Dickie Lois , McNeel Timothy S , Noone Annie M , Ohm Bradley , White Dolly P , Warren Joan L , Mariotto Angela B , Penberthy Lynne 
Published: December 2019

Abstract

Purpose
Health-care claims are of increasing utility as a rich, real-world data resource for conducting treatment-related cancer research. However, multiple dynamic coding nomenclatures exist, leading to study variability. To promote increased standardization and reproducibility, the National Cancer Institute (NCI) developed the Cancer Medications Enquiry Database (CanMED)-Healthcare Common Procedure Coding System (HCPCS) within the Observational Research in Oncology Toolbox.

Methods
The CanMED-HCPCS includes codes for oncology medications that a) have a US Food and Drug Administration-approved indication for cancer treatment or treatment-related symptom management; b) are present in National Comprehensive Cancer Network guidelines; or c) carry an orphan drug designation for treatment or management of cancer. Included medications and their HCPCS codes were primarily identified based on Center for Medicare and Medicaid Services annual HCPCS Indices (2012–2018). To demonstrate the utility of the CanMED-HCPCS, use of systemic treatment for stage II–IV colorectal cancer patients included in the Surveillance, Epidemiology, and End Results-Medicare data (2007–2013) was assessed.

Results
The CanMED-HCPCS (v2018) includes 332 HCPCS codes for cancer-related medications: chemotherapy (156), immunotherapy (74), hormonal therapy (54), and ancillary therapy (48). Observed treatment trends within the NCI Surveillance, Epidemiology, and End Results-Medicare data were as expected; utilization of each treatment type increased with stage, and immunotherapy was largely confined to use among stage IV patients.

Conclusion
The CanMED-HCPCS provides a comprehensive resource that can be used by the research community to facilitate systematic identification of medications within claims or electronic health data using the HCPCS nomenclature and greater reproducibility of cancer surveillance and health services research.