bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative identification of cardiac surgery patients at risk of receiving a platelet transfusion: The Australian Cardiac Surgery Platelet Transfusion (ACSePT) risk prediction tool
Authors: Flint Andrew W. J. , Bailey Michael , Reid Christopher M. , Smith Julian A. , Tran Lavinia , Wood Erica M. , McQuilten Zoe K. , Reade Michael C. 
Published: August 2020

BackgroundPlatelet (PLT) transfusions are limited and costly resources. Accurately predicting clinical demand while limiting product wastage remains difficult. A PLT transfusion prediction score was developed for use in cardiac surgery patients who commonly require PLT transfusions.Study Design and MethodsUsing the Australian and New Zealand Society of Cardiac and Thoracic Surgeons National Cardiac Surgery Database, significant predictors for PLT transfusion were identified by multivariate logistic regression. Using a development data set containing 2005 to 2016 data, the Australian Cardiac Surgery Platelet Transfusion (ACSePT) risk prediction tool was developed by assigning weights to each significant predictor that corresponded to a probability of PLT transfusion. The predicted probability for each score was compared to actual PLT transfusion occurrence in a validation (2017) data set.ResultsThe development data set contained 38 independent variables and 91 521 observations. The validation data set contained 12 529 observations. The optimal model contained 23 variables significant at P < .001 and an area under the receiver operating characteristic (ROC) curve of 0.69 (95% confidence interval [CI], 0.68‐0.69). ACSePT contained nine variables and had an area under the ROC curve of 0.66 (95% CI, 0.65‐0.66) and overall predicted probability of PLT transfusion of 19.8% for the validation data set compared to an observed risk of 20.3%.ConclusionThe ACSePT risk prediction tool is the first scoring system to predict a cardiac surgery patientʼs risk of receiving a PLT transfusion. It can be used to identify patients at higher risk of receiving PLT transfusions for inclusion in clinical trials and by PLT inventory managers to predict PLT demand.
Measuring fifty years of trade globalisation
Authors: Palan Nicole , Simoes Nadia , Crespo Nuno 
Published: August 2020

AbstractAlthough trade globalisation is a multi‐faceted phenomenon, researchers often capture its magnitude by trade volume alone. In order to gain a deeper understanding of the phenomenon, we propose measures that also account for the interconnectedness of countries, for geographical distance and for the role of individual sectors in bilateral trade. We also improve upon existing indices by moving from a country‐level analysis (internationalisation) to a truly global perspective (globalisation). We measure trade globalisation using data from CHELEM (CEPII) over a period of 50 years, covering 72 countries for the sub‐period 1967–90 and 84 countries for 1994–2016. The results show substantial increases in all dimensions of globalisation, despite substantial differences between the measures, highlighting the need to analyse globalisation with a comprehensive set of indicators. Regarding the number of positive bilateral trade flows, globalisation was almost completed by 2016. The importance of distance also diminished throughout the period analysed, but neighbouring countries still share stronger trade relations. Results indicate that trade globalisation for high‐tech sectors varies significantly from the evolution seen in other sectors, especially large, low‐tech sectors. The latter tend to show the highest level of trade globalisation over the whole period, but the former group could catch up considerably in the future.
Comparative Study of Thermal and Hydraulic Performance of Three-Fluid Tubular Heat Exchanger With CuO–Water Nanofluid: Single-Phase and Multi-Phase Approaches
Authors: Amanuel Tarikayehu , Mishra Manish 
Published: August 2020

Abstract
Comparative analysis of the thermal and hydraulic performance of three-fluid tubular heat exchanger has been carried out numerically. Single-phase and multi-phase approaches for the turbulent flow of CuO–water nanofluids have been applied. The effect of Reynolds number (2500–10,000) and volume concentration of nanoparticles (0–3%) on the overall performance of the selected heat exchanger has been investigated. The numerical simulation has been performed using a finite volume approach in commercial computational fluid dynamics (CFD) software for two flow arrangements (parallel and counter). Nusselt number was found to increase with the growth in Reynolds number as well as volume concentration of nanoparticles in both the flow arrangements. Particularly, for a maximum volume concentration of nanoparticles (φ = 3%), single-phase approach resulted in an increase of 8.94% for parallel and 11.52% for counterflow arrangements. However, multi-phase approach produced a remarkable increase of 30.37% for parallel and 32.04% for counterflow arrangement. Single-phase approach was applied for treating the nanofluids as homogenous fluids with effective thermophysical properties, meaning that the entire suspension is assumed to act as a single unit with the same velocity. However, the multi-phase model was applied to separately treat the two phases with different velocities.
Joule Heating in Rectangular Conductors
Authors: Wang C. Y. 
Published: August 2020

Abstract
Analytic solution for nonuniform internal Joule heating in a wire of rectangular cross section is obtained. The eigenvalues for convective or weak radiative boundary conditions are accurately estimated by asymptotic expansions. The problem is governed by the aspect ratio, the convection parameter β, and a nonuniform parameter α which relates to the slope of the electric resistivity. There exists a maximum α above which the conductor would fail due to high temperature.
Data-Oriented State Space Discretization for Crowdsourced Robot Learning of Physical Skills
Authors: Zhao Leidi , Lu Lu , Wang Cong 
Published: August 2020

AbstractThis work discusses a crowdsourced learning scheme for robot physical intelligence. Using a large amount of data from crowdsourced mentors, the scheme allows robots to synthesize new physical skills that are never demonstrated or only partially demonstrated without heavy re-training. The learning scheme features a data management method to sustainably manage continuously collected data and a growing knowledge library. The method is validated using a simulated challenge of solving a bottle puzzle. The learning scheme aims at realizing ubiquitous robot learning of physical skills and has the potential of automating many demanding tasks that are currently hard to robotize.
Hypercalcaemia in a dog with lymphoma without increases in parathyroid hormone, parathyroid hormone‐related protein and vitamin D metabolites concentrations
Authors: Mullany Alex , Waddington Abigail , Mellanby Richard J 
Published: August 2020

SUMMARYLymphoma is one of the most common causes of hypercalcaemia in dogs. Typically, the hypercalcaemic state is driven by ectopic production of parathyroid hormone‐related protein by the malignant lymphoma cells. In this case report, the authors describe the diagnosis of lymphoma in a dog with hypercalcaemia which had a plasma parathyroid hormone‐related protein concentration within the reference range. Furthermore, circulating concentrations of the two other main hormones which are known to increase serum calcium concentrations, namely parathyroid hormone and 1,25 dihydroxyvitamin D, were also below the upper limits of their respective reference ranges. This case report highlights that hypercalcaemia is not invariably mediated by increases in circulating concentrations of parathyroid hormone‐related protein. In addition, it emphasises the need to further investigate the pathophysiology of malignancy‐related hypercalcaemia in dogs.
Real and imaginary edge states in stacked Floquet honeycomb lattices
Authors: Fritzsche Alexander , Höckendorf Bastian , Alvermann Andreas , Fehske Holger 
Published: August 2020

Abstract

We present a non-Hermitian Floquet model with topological edge states in real and imaginary band gaps. The model utilizes two stacked honeycomb lattices which can be related via four different types of non-Hermitian time-reversal symmetry. Implementing the correct time-reversal symmetry provides us with either two counterpropagating edge states in a real gap, or a single edge state in an imaginary gap. The counterpropagating edge states allow for either helical or chiral transport along the lattice perimeter. In stark contrast, we find that the edge state in the imaginary gap does not propagate. Instead, it remains spatially localized while its amplitude continuously increases. Our model is well-suited for realizing these edge states in photonic waveguide lattices.

Graphical abstract
Isospin-breaking in $$\varepsilon '/\varepsilon $$: impact of $$\eta _0$$ at the dawn of the 2020s
Authors: Buras Andrzej J. , Gérard Jean-Marc 
Published: August 2020

AbstractFor direct CP-violation in $$K\rightarrow \pi \pi $$K→ππ decays, the usual isospin-breaking effects at the percent level are amplified by the dynamics behind the $$\Delta I=1/2$$ΔI=1/2 rule and conventionally encoded in $$\Omega _\mathrm{IB}$$ΩIB parameters. The updated prediction $$\Omega _\mathrm{IB}^{(8)}=(15.9\pm 8.2)\times 10^{-2}$$ΩIB(8)=(15.9±8.2)×10-2 of the Chiral Perturbation Theory for the strong isospin-breaking due to $$\pi _3-\eta _8$$π3-η8 mixing confirms such a tendency but is quite sensitive to the theoretical input value of the low-energy constant corresponding to the flavour-singlet $$\eta _0$$η0 exchange contribution in this truncated octet scheme. We rather exploit the phenomenological $$\eta _8-\eta _0$$η8-η0 mixing as a probe for the non-negligible flavour-singlet component of the physical $$\eta $$η pole to find $$\Omega _\mathrm{IB}^{(9)}=(35\pm 7)\times 10^{-2}$$ΩIB(9)=(35±7)×10-2 in a complete nonet scheme. A large central value in the nonet scheme is thus substituted for a large uncertainty in the octet one. Including the experimental $$\pi ^+-\pi ^0$$π+-π0 mass difference as the dominant electromagnetic isospin-breaking, we obtain for the effective parameter entering the ratio $$\varepsilon '/\varepsilon $$ε′/ε an improved result $$\hat{\Omega }_\mathrm{eff}^{(9)}=(29\pm 7)\times 10^{-2}$$Ω^eff(9)=(29±7)×10-2 to be compared with $$\hat{\Omega }_\mathrm{eff}^{(8)}=(17\pm 9)\times 10^{-2}$$Ω^eff(8)=(17±9)×10-2 used in recent analyses of $$\varepsilon '/\varepsilon $$ε′/ε. Accordingly, we get a reduction from $$(\varepsilon '/\varepsilon )_\text {SM}^{(8)}=(17.4\pm 6.1)\times 10^{-4}$$(ε′/ε)SM(8)=(17.4±6.1)×10-4 to $$(\varepsilon '/\varepsilon )_\text {SM}^{(9)}=(13.9\pm 5.2)\times 10^{-4}$$(ε′/ε)SM(9)=(13.9±5.2)×10-4 and thereby an effective suppression of $$(\varepsilon '/\varepsilon )_\text {SM}$$(ε′/ε)SM by isospin-breaking corrections as large as $$40\%$$40% relative to the recent RBC-UKQCD value.
Cross-dressing of CD8α+ Dendritic Cells with Antigens from Live Mouse Tumor Cells Is a Major Mechanism of Cross-priming
Authors: Das Mohapatra Alok , Tirrell Isaac , Bénéchet Alexandre P. , Pattnayak Shashmita , Khanna Kamal M. , Srivastava Pramod K. 
Published: August 2020

Abstract
Live cells are the most abundant sources of antigen in a tumor-bearing host. Here, we used live tumor cells as source of antigens to investigate the mechanism underlying their immunogenicity in murine tumor models. The live tumor cells were significantly more immunogenic than irradiated or apoptotic tumor cells. We examined the interaction of live and apoptotic tumor cells with major subsets of antigen-presenting cells, i.e., CD8α+ dendritic cells (DC), CD8α− DCs, plasmacytoid DCs, and CD169+ macrophages at skin draining lymph nodes. The CD8α+ DCs captured cell-associated antigens from both live and apoptotic tumor cells, whereas CD169+ macrophages picked up cell-associated antigens mostly from apoptotic tumor cells. Trogocytosis and cross-dressing of membrane-associated antigenic material from live tumor cells to CD8α+ DCs was the primary mechanism for cross-priming of tumor antigens upon immunization with live cells. Phagocytosis of apoptotic tumor cells was the primary mechanism for cross-priming of tumor antigens upon immunization with apoptotic or irradiated cells. These findings clarify the mechanism of cross-priming of cancer antigens by DCs, allowing for a greater understanding of antitumor immune responses.
Crossmodal Visuospatial Effects on Auditory Perception of Musical Contour
Authors: Lacey Simon , Nguyen James , Schneider Peter , Sathian K. 
Published: August 2020

Abstract
The crossmodal correspondence between auditory pitch and visuospatial elevation (in which high- and low-pitched tones are associated with high and low spatial elevation respectively) has been proposed as the basis for Western musical notation. One implication of this is that music perception engages visuospatial processes and may not be exclusively auditory. Here, we investigated how music perception is influenced by concurrent visual stimuli. Participants listened to unfamiliar five-note musical phrases with four kinds of pitch contour (rising, falling, rising–falling, or falling–rising), accompanied by incidental visual contours that were either congruent (e.g., auditory rising/visual rising) or incongruent (e.g., auditory rising/visual falling) and judged whether the final note of the musical phrase was higher or lower in pitch than the first. Response times for the auditory judgment were significantly slower for incongruent compared to congruent trials, i.e., there was a congruency effect, even though the visual contours were incidental to the auditory task. These results suggest that music perception, although generally regarded as an auditory experience, may actually be multisensory in nature.
Comparative genomic analysis of eutherian fibroblast growth factor genes
Authors: Premzl Marko 
Published: August 2020

AbstractBackgroundThe eutherian fibroblast growth factors were implicated as key regulators in developmental processes. However, there were major disagreements in descriptions of comprehensive eutherian fibroblast growth factors gene data sets including either 18 or 22 homologues. The present analysis attempted to revise and update comprehensive eutherian fibroblast growth factor gene data sets, and address and resolve major discrepancies in their descriptions using eutherian comparative genomic analysis protocol and 35 public eutherian reference genomic sequence data sets.ResultsAmong 577 potential coding sequences, the tests of reliability of eutherian public genomic sequences annotated most comprehensive curated eutherian third-party data gene data set of fibroblast growth factor genes including 267 complete coding sequences. The present study first described 8 superclusters including 22 eutherian fibroblast growth factor major gene clusters, proposing their updated classification and nomenclature.ConclusionsThe integrated gene annotations, phylogenetic analysis and protein molecular evolution analysis argued that comprehensive eutherian fibroblast growth factor gene data set classifications included 22 rather than 18 homologues.
Plasma Ephrin-A1 level in a cohort of diabetic retinopathy patients
Authors: Mao Danna , Hu Ying , Bao Qi , Wu Kewei , Zheng Yaoding , Yang Yukun , Lei Bo , Jiang Ying 
Published: August 2020

Abstract
Background
To determine plasma ephrin-A1 and VEGF165 levels in a cohort of diabetic retinopathy patients.

Methods
Plasma ephrin-A1 and VEGF165 levels in fifty-five subjects including 19 individuals without diabetes (non-DM), 16 patients with diabetes (DM) but without diabetic retinopathy, and 20 patients with diabetic retinopathy (DR), were determined by ELISA. Serum creatinine, total cholesterol, fasting blood glucose and HbA1c were also measured. One-way ANOVA, Kruskal-Wallis Test, Mann-Whitney U Test corrected by Bonferroni, Pearson Correlation Analysis and Spearman Correlation Coefficient Analysis were used for data analysis.

Results
Ephrin-A1 expression could be detected in human plasma with an average of 1.52 ± 0.43 (mean ± SEM) ng/ml. In DR subjects, the plasma ephrin-A1concentration was 3.63 ± 4.63 ng/ml, which was significantly higher than that of the other two groups (non-DM: 0.27 ± 0.13 ng/ml, DM: 0.35 ± 0.34 ng/ml). The expression of VEGF165 in human plasma was 34.00 ± 42.55 pg/ml, with no statistical difference among the three groups. There was no correlation between ephrin-A1 and VEGF165 in human plasma, but there was a correlation between plasma ephrin-A1 and duration of diabetes.

Conclusions
Plasma ephrin-A1 was highly expressed in patients with diabetic retinopathy, and there was no difference of plasma VEGF165 expression in patients with diabetic retinopathy compared to the other two groups, suggesting that changes of plasma ephrin-A1 may be a more sensitive biomarker than plasma VEGF165 in detecting diabetic retinopathy.
Dimensionality and psychometric analysis of DLQI in a Brazilian population
Authors: Jorge Marilia F. S. , Sousa Ticiane D. , Pollo Camila F. , Paiva Bianca S. R. , Ianhez Mayra , Boza Juliana C. , Meneguin Silmara , Schmitt Juliano V. , Nunes Daniel Holthausen , Lastoria Joel C. , Miot Hélio A. 
Published: August 2020

Abstract
Background
The Dermatology Life Quality Index (DLQI) is the most commonly used instrument for clinical evaluation of the impact on health-related quality of life (HRQOL) in dermatological research protocols. The DLQI’s classical psychometric properties have been considered adequate in validation studies from several countries. However, the structure of the DLQI is a matter of discussion, especially concerning the dimensionality and informative properties of its questions according to the item response theory (IRT).

Methods
Pooled data from studies in Brazil that utilized the DLQI to assess HRQOL in 14 dermatoses were reanalyzed. Classical psychometrical analysis, dimensionality assessment through parallel analysis and IRT (Samejima’s ordinal model) analysis were performed.

Results
The sample consisted of 1286 patients with a mean age of 47 years (SD = 16), and the proportion of women was 59% (765). The DLQI scores ranged from 0 to 29, with a median (p25–p75) of 5 (2–11). All items indicated significant correlations with the total DLQI score (rho > 0.54). The Cronbach’s alpha result was 0.90 (CI 95% 0.89–0.91). Parallel analysis indicated a unidimensional factor structure. According to IRT analysis, items q6 (sports) and q7 (work/study) exhibited insufficient fit to the model (p < 0.01), while the items that indicated the best discrimination and information functions were q2 (embarrassment), q3 (shopping/gardening), q4 (clothing) and q5 (social/leisure). The ordination of the scores was confirmed for all items. Most items revealed non-uniform behavior according to sex, age and type of disease.

Conclusions
The DLQI exhibits adequate psychometric reliability and a unidimensional structure for assessing HRQOL in Brazilian dermatological patients. The DLQI’s performance varies in the assessment of HRQOL in heterogeneous samples.
International variation in the management of severe COVID-19 patients
Authors: Azoulay Elie , de Waele Jan , Ferrer Ricard , Staudinger Thomas , Borkowska Marta , Povoa Pedro , Iliopoulou Katerina , Artigas Antonio , Schaller Stefan J. , Shankar-Hari Manu , Pellegrini Mariangela , Darmon Michael , Kesecioglu Jozef , Cecconi Maurizio 
Published: August 2020

Abstract
Background
There is little evidence to support the management of severe COVID-19 patients.

Methods
To document this variation in practices, we performed an online survey (April 30–May 25, 2020) on behalf of the European Society of Intensive Care Medicine (ESICM). A case vignette was sent to ESICM members. Questions investigated practices for a previously healthy 39-year-old patient presenting with severe hypoxemia from COVID-19 infection.

Results
A total of 1132 ICU specialists (response rate 20%) from 85 countries (12 regions) responded to the survey. The survey provides information on the heterogeneity in patient’s management, more particularly regarding the timing of ICU admission, the first line oxygenation strategy, optimization of management, and ventilatory settings in case of refractory hypoxemia. Practices related to antibacterial, antiviral, and anti-inflammatory therapies are also investigated.

Conclusions
There are important practice variations in the management of severe COVID-19 patients, including differences at regional and individual levels. Large outcome studies based on multinational registries are warranted.
Existence result for a Kirchhoff elliptic system with variable parameters and additive right-hand side via sub- and supersolution method
Authors: Haiour Mohamed , Boulaaras Salah , Bouizem Youcef , Guefaifia Rafik 
Published: August 2020

AbstractThe paper deals with the study of the existence result for a Kirchhoff elliptic system with additive right-hand side and variable parameters by using the sub-/supersolution method. Our study is a natural extension result of our previous one in (Boulaaras and Guefaifia in Math. Methods Appl. Sci. 41:5203–5210, 2018), where we discussed only the simple case when the parameters are constant.
Primary chemoradiation with cisplatin versus cetuximab for locally advanced head and neck cancer: a retrospective cohort study
Authors: Jeong Il Seok Daniel , Mo Huan , Nguyen Anthony , Chong Esther G. , Tsai Hsin Hsiang Clarence , Moyers Justin , Kim Matthew , Lacy Curtis , Shah Vivek , Lau Eric , Xu Yi , Cao Huynh 
Published: August 2020

Abstract
Objective
To explore the efficacy of primary chemoradiation with cisplatin versus cetuximab with respect to HPV/p16 and smoking statuses.

Methods
We retrospectively reviewed patients from our center with locally advanced non-nasopharyngeal head and neck squamous cell carcinoma (HNSCC) who received primary chemoradiation with cisplatin or cetuximab between 2006 and 2018.

Results
The median OS for cisplatin (n = 66) was not reached versus 132 months when treated with cetuximab (n = 55) (p = 0.03). For HPV/p16-positive patients, we found the median OS for cisplatin (n = 34) was not reached versus 60 months with cetuximab (n = 21) (p = 0.036). In the smoking group, the median OS was not reached in the cisplatin group (n = 44) versus 60 months when treated with cetuximab (n = 32) (p = 0.03).

Conclusion
HPV/p16-positive and smoking cohorts treated with cisplatin-based chemoradiotherapy had a significantly better OS versus cetuximab.