bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk‐stratifying clinicopathologic criteria for ovarian preservation in premenopausal women with early stage low‐risk endometrial cancer
Authors: Khadraoui Wafa , Tierney Christina , Chung Sophie , Mutlu Levent , Lu Lingeng , Azodi Masoud , Ratner Elena , Menderes Gulden 
Published: June 2020

AbstractObjectiveTo establish the rate of occult ovarian micro‐metastases in early stage disease and to provide an eligibility framework for providers to consider ovarian preservation in a patient population with presumed early stage disease.MethodsA retrospective review from January 2005 to December 2010 identified women with presumed early stage endometrial cancer from a single institutional database. Inclusion criteria included: (1) FIGO grade 1 endometrioid endometrial cancer on endometrial biopsy; or (2) the same pathology as (1) on frozen section specimen with less than 50% myometrial biopsy; and (3) no evidence of metastatic disease on preoperative imaging or visible metastatic disease in the peritoneal cavity.ResultsOf the 52 patients, 86.5% were diagnosed with stage IA and 11.5% were diagnosed with stage II disease. One patient (1.9%) had microscopic adnexal involvement in a fallopian tube, which upstaged her to stage IIA disease. None of the patients had ovarian involvement.ConclusionPreservation of the ovaries appears to be a safe and viable option for premenopausal women who are diagnosed with presumed early stage endometrioid endometrial cancer. It is believed that ovarian preservation in this select population will provide them with significant health benefits and improve their quality of life.
Antecedents of fathers’ perception of child behavior at child age 12 months
Authors: Skjothaug Thomas , Smith Lars , Wentzel‐Larsen Tore , Stänicke Erik , Moe Vibeke 
Published: June 2020

ABSTRACTThis study investigates whether fathers’ adverse childhood experiences (ACE) and attachment style reported during pregnancy predict fathers’ perception of child behavior assessed 12 months postpartum, expressed by the Parenting Stress Index (PSI), Child Domain. Prospective fathers (N = 835) were recruited to “The Little in Norway (LiN) study” (Moe & Smith) at nine well‐baby clinics in Norway, with data collection composed of five time points during pregnancy and two time points postpartum (6 and 12 months). The main analyses included linear regression, path‐analysis modeling, and intraclass correlation based on mixed effects modeling. First, linear regression analyses showed that neither fathers’ ACE nor attachment style significantly predicted perceived child behavior postpartum directly. Furthermore, path analyses showed that ACE and less secure attachment style (especially avoidant attachment) measured early in pregnancy strongly predicted negatively perceived child behavior, mediated by fathers’ mental health symptoms during pregnancy and partner disharmony postpartum. Second, intraclass correlation analyses showed that fathers’ perceived child behavior showed substantial stability between 6 and 12 months postpartum. Family interventions beginning in pregnancy may be most beneficial given that fathers’ early experiences and perceptions of attachment in pregnancy were associated with later partner disharmony and stress.
Machine learning of diffraction image patterns for accurate classification of cells modeled with different nuclear sizes
Authors: Liu Jing , Xu Yaohui , Wang Wenjin , Wen Yuhua , Hong Heng , Lu Jun Q. , Tian Peng , Hu Xin‐Hua 
Published: June 2020

AbstractMeasurement of nuclear‐to‐cytoplasm (N:C) ratios plays an important role in detection of atypical and tumor cells. Yet, current clinical methods rely heavily on immunofluroescent staining and manual reading. To achieve the goal of rapid and label‐free cell classification, realistic optical cell models (OCMs) have been developed for simulation of diffraction imaging by single cells. A total of 1892 OCMs were obtained with varied nuclear volumes and orientations to calculate cross‐polarized diffraction image (p‐DI) pairs divided into three nuclear size groups of OCMS, OCMO and OCML based on three prostate cell structures. Binary classifications were conducted among the three groups with image parameters extracted by the algorithm of gray‐level co‐occurrence matrix. The averaged accuracy of support vector machine (SVM) classifier on test dataset of p‐DI was found to be 98.8% and 97.5% respectively for binary classifications of OCMS vs OCMO and OCMO vs OCML for the prostate cancer cell structure. The values remain about the same at 98.9% and 97.8% for the smaller prostate normal cell structures. The robust performance of SVM over clustering classifiers suggests that the high‐order correlations of diffraction patterns are potentially useful for label‐free detection of single cells with large N:C ratios.
Contraction of fibrin‐derived matrices and its implications for in vitro human skin bioengineering
Authors: Montero Andrés , Acosta Sonia , Hernández Rebeca , Elvira Carlos , Jorcano José Luis , Velasco Diego 
Published: June 2020

AbstractIt is well‐known that fibroblasts play a fundamental role in the contraction of collagen and fibrin hydrogels when used in the production of in vitro bilayered skin substitutes. However, little is known about the contribution of other factors, such as the hydrogel matrix itself, on this contraction. In this work, we studied the contraction of plasma‐derived fibrin hydrogels at different temperatures (4, 23, and 37°C) in an isotonic buffer (phosphate‐buffered saline). These types of hydrogels presented a contraction of approximately 30% during the first 24 hr, following a similar kinetics irrespectively of the temperature. This kinetics continued in a slowed down manner to reach a plateau value of 40% contraction after 10–15 days. Contraction of commercial fibrinogen hydrogels was studied under similar conditions and the kinetics was completed after 8 hr, reaching values between 20 and 70% depending on the temperature. We attribute these substantial differences to a modulatory effect on the contraction due to plasma proteins which are initially embedded in, and progressively released from, the plasma‐based hydrogels. The elastic modulus of hydrogels measured at a constant frequency decreased with increasing temperature in 7‐day gels. Rheological measurements showed the absence of a strain‐hardening behavior in the plasma‐derived fibrin hydrogels. Finally, plasma‐derived fibrin hydrogels with and without human primary fibroblast and keratinocytes were prepared in transwell inserts and their height measured over time. Both cellular and acellular gels showed a height reduction of 30% during the first 24 hr likely due to the above‐mentioned intrinsic fibrin matrix contraction.
Anionic behavior and single‐molecule crystal in fullerene confinements: A contribution from DFT energy decomposition and cooperativity analyses
Authors: Alipour Mojtaba , Kargar Kimia 
Published: June 2020

AbstractThe recently proposed systems of various anions (A) confined inside C60, A− @ C60, which in turn behave as large and stable anions, (A @ C60)−, can find potential applications in various fields. On the other hand, it has earlier been shown that from the dihalogens (X2) encapsulated C60, X2 @ C60, only F2 @ C60 can be introduced as a system in which the cage acts as a cation C60+ and interacts with an endohedral anion, F2−, forming the F2− @ C60+ as a single‐molecule crystal compound. In this work, two density functional theory energy decomposition analysis (EDA) schemes, where in one of them the noninteracting kinetic, electrostatic, and exchange‐correlation energies come into play while another scheme, called as EDA‐SBL, includes the steric, electrostatic, and quantum effects as essential ingredients (S. Liu, J. Chem. Phys. 2007, 126, 244103), are utilized to find out what energetic components govern the unique characteristics of the (A @ C60)− and X2 @ C60 confinements. It is shown that the noninteracting kinetic energy and steric energies have important contributions to the total interaction energies for the considered systems. However, there are other confinements for which the electrostatic and exchange‐correlation contributions play also imperative roles. Furthermore, we find reasonable correlations between interaction energies and their components as well as the energetic components themselves, leading to an alternative EDA scheme including the noninteracting kinetic, steric, and electrostatic energies for investigations on other endohedral fullerenes. Extending our analyses to large size confinements, Cl− @ Cn with n up to 90 as illustrative examples, the quantitative cooperativity concept is also explored, where the positive and negative cooperativity profiles unveil a specific size of the anionic confinements to form the most stable large anion.
Symmetric designs and projective special linear groups of dimension at most four
Authors: Alavi Seyed Hassan , Bayat Mohsen , Daneshkhah Asharf 
Published: June 2020

AbstractIn this article, we study symmetric designs admitting a flag‐transitive and point‐primitive automorphism group whose socle is isomorphic to a projective special linear group of dimension at most four. We, in particular, determine all such possible parameters and show that such a design belongs to one of two infinite families of point‐hyperplane designs or it is isomorphic to a design with parameters (7, 3, 1), (7, 4, 2), (11, 5, 2), (11, 6, 3), (15, 8, 4), (35, 18, 9), or (56, 45, 18).
Clinical features of COVID‐19 convalescent patients with re‐positive nucleic acid detection
Authors: Zhu Hui , Fu Liyun , Jin Yinhua , Shao Jiale , Zhang Shun , Zheng Nanhong , Fan Lingyan , Yu Zhe , Ying Jun , Hu Yaoren , Chen Tongen , Chen Yanglingzi , Chen Min , Chen Mingjue , Xiong Zi , Kang Junfei , Jin Jiachang , Cai Ting , Ye Honghua 
Published: June 2020

AbstractBackgroundCoronavirus disease 2019 (COVID‐19) is a pandemic that has rapidly spread worldwide. Increasingly, confirmed patients being discharged according to the current diagnosis and treatment protocols, follow‐up of convalescent patients is important to knowing about the outcome.MethodsA retrospective study was performed among 98 convalescent patients with COVID‐19 in a single medical center. The clinical features of patients during their hospitalization and 2‐week postdischarge quarantine were collected.ResultsAmong the 98 COVID‐19 convalescent patients, 17 (17.3%) were detected positive severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) nucleic acid during 2‐week postdischarge quarantine. The median time from discharge to SARS‐CoV‐2 nucleic acid re‐positive was 4 days (IQR, 3‐8.5).The median time from symptoms onset to final respiratory SARS‐CoV‐2 detection of negative result was significantly longer in re‐positive group (34 days [IQR, 29.5‐42.5]) than in non‐re‐positive group (19 days [IQR, 16‐26]). On the other hand, the levels of CD3‐CD56 + NK cells during hospitalization and 2‐week postdischarge were higher in re‐positive group than in non‐re‐positive group (repeated measures ANOVA, P = .018). However, only one case in re‐positive group showed exudative lesion recurrence in pulmonary computed tomography (CT) with recurred symptoms.ConclusionIt is still possible for convalescent patients to show positive for SARS‐CoV‐2 nucleic acid detection, but most of the re‐positive patients showed no deterioration in pulmonary CT findings. Continuous quarantine and close follow‐up for convalescent patients are necessary to prevent possible relapse and spread of the disease to some extent.
Feasibility of CANON process for treating nitrogenous wastewater containing heavy metals
Authors: Chen Zhao , Zhang Xiaojing , Ma Yongpeng , Li Shilei , Pang Qi , Wang Haoxu , Sun Gaochao 
Published: June 2020

AbstractThe appearance of heavy metals in wastewater brings a major burden to wastewater treatment plants, due to the high toxicity to microorganisms. Several commonly used heavy metals, including Zn(II), Cd(II), Hg(II), and Pb(II) were adopted to clear the individual and joint toxicity to the completely autotrophic nitrogen removal over nitrite (CANON) process in six sequencing batch reactors. The obtained results suggested that the nitrogen removal performances were transiently inhibited, but rapidly recovered. The restoration period under the stress of Hg(II) and Pb(II) was shorter than that under Zn(II), Cd(II), and the joint heavy metals. During the long‐term exposure, Cd(II) in 1mg L−1 slightly inhibited the nitrogen removal, while Zn(II), Hg(II), Pb(II), and mixture showed a negligible impact on CANON process. The defense of extracellular polymeric substances (EPS), the good adaptability of functional bacteria, and the inducement of resistant genera by heavy metals all contributed to the robustness and stability of CANON process. Therefore, it is feasible to treat nitrogenous wastewater containing low heavy metals using CANON process. © 2020 Society of Chemical Industry
Prenatal sonographic features of fetal mediastinal teratoma
Authors: Srisupundit Kasemsri , Sukpan Kornkanok , Tongsong Theera , Traisrisilp Kuntharee 
Published: June 2020

AbstractMediastinal teratoma can cause severe hydrops fetalis, which worsens the effects of the mass compression on the vital mediastinal organs. A careful sonographic examination is mandatory to demonstrate the characteristic features suggestive of this congenital tumor. We describe these features at 20 weeks gestation. The most prominent finding was the heterogeneous echogenicity of a large cystic‐solid mass with hyperechoic dots, seen as a part of the anterior mediastinum immediately posterior to the sternum. Additional diagnostic features included posterior displacement of the heart, low cardiac output, and hypoplasia of the normally structured heart and lungs due to the direct mass compression. These sonographic findings were confirmed at autopsy which confirmed a nonmetastatic immature teratoma. Sonography may enable accurate diagnosis of mediastinal teratoma considering the anterior location and heterogeneous appearance of the mass, posterior displacement of the heart, normal lung morphology, and compression effects on these organs.
Sternal osteomyelitis and infective endocarditis after old trivial chest trauma in untreated diabetes mellitus: A case report
Authors: Kurihara Ibuki , Kashiura Masahiro , Moriya Takashi , Sugawara Hitoshi 
Published: June 2020

AbstractAn 82‐year‐old man with untreated diabetes mellitus (DM) had anterior chest wall swelling and ulcers 2 years following blunt chest trauma. Contrast‐enhanced computed tomography revealed sternal fracture with osteolytic change and subcutaneous abscess. Blood and sternal cultures were positive for methicillin‐susceptible Staphylococcus aureus (MSSA). Transesophageal echocardiogram showed vegetation on the right coronary cusp and moderate aortic regurgitation. The patient received a diagnosis of infective endocarditis associated with chronic sternal osteomyelitis complicated by subcutaneous abscess because of MSSA. This case report showed that trivial trauma in patients with uncontrolled DM can cause chronic sternal osteomyelitis resulting in infective endocarditis.
Risk factors for dysfunction of preoperative endoscopic biliary drainage for malignant hilar biliary obstruction
Authors: Sugiura Ryo , Kuwatani Masaki , Kato Shin , Kawakubo Kazumichi , Kamachi Hirofumi , Taketomi Akinobu , Noji Takehiro , Okamura Keisuke , Hirano Satoshi , Sakamoto Naoya 
Published: June 2020

AbstractBackgroundFew studies have focused on the risk factors for dysfunction of endoscopic biliary drainage (EBD) in preoperative patients with malignant hilar biliary obstruction (MHBO).MethodsWe searched the database between February 2011 and December 2018 and identified patients with MHBO who underwent radical operation. The rate of dysfunction of the initial EBD, risk factors for dysfunction of the initial EBD and survival after surgery were retrospectively evaluated.ResultsWe analyzed a total of 131 patients [95 males (72.5%); mean age, 69.5 (±7.3) years; Bismuth‐Corlette classification (BC) I/II/IIIa/IIIb/IV, 50/26/22/17/16; hilar cholangiocarcinoma/gall bladder cancer, 115/16]. Dysfunction of the initial EBD occurred in 28 patients (21.4%). The cumulative incidences of dysfunction of the initial EBD in all patients were 18.4%, 38.2% and 47.0% at 30, 60 and 90 days, respectively (Kaplan–Meier method). The rate of dysfunction of the initial EBD increased in patients with BC‐IV (P = .03). Multivariate analysis showed that BC‐IV and pre‐EBD cholangitis were significantly associated with the occurrence of dysfunction of the initial EBD. Survival rates were not significantly different according to the initial biliary drainage methods and presence/absence of the initial EBD dysfunction.ConclusionsDysfunction of the initial EBD frequently occurs in patients with the BC‐IV and those with pre‐EBD cholangitis.
Modification of a new subclassification of Grade B postoperative pancreatic fistula: A bicenter retrospective cohort study
Authors: Xu Jingyong , Zhang Aoran , Tang Bingjun , Tian Xiaodong , Ma Yongsu , Song Jinghai , Qiao Jiangchun , Wei Junmin , Chen Jian , Yang Yinmo 
Published: June 2020

AbstractAimTo propose a modified subclassification of grade B postoperative pancreatic fistula (POPF) based on management approaches in Chinese patients.MethodsData of consecutive pancreatoduodenectomy at two hospitals in China from 2013 to 2018 were collected, and outcomes were compared across different groups of POPF. Subclassification of B‐POPF was made based on intervention to B1: non‐interventional subclass and B2: interventional subclass.ResultsA total of 142 of 522 patients had biochemical leaks (BLs) (27.2%), and POPFs developed in 106 of 522 patients (20.3%), with 81 B‐POPFs (15.5%) and 25 C‐POPFs (4.8%). BL did not differ from the non‐fistula condition in almost all outcomes. The differences of outcomes among the non‐fistula/BL, B‐POPF and C‐POPF groups were significant. The prevalence of subclass B1 and B2 was 56.8% (46/81) and 43.2% (35/81), respectively. Compared to the B1 group, patients in the B2 group had worse outcomes, such as post‐pancreatectomy hemorrhage (15.2% vs 34.3%, P = .045), biliary fistula (13.0% vs 34.3%, P = .023), postoperative hospital stay (32 vs 39 days, P = .011), and cost ($US28 601.0 vs $US39 314.5, P < .001).ConclusionThe recently reported B‐POPF subclassification method was modified in Chinese patients according to the intervention, and is more practical, simpler and fits Chinese patients.
New insight into the association between bile infection and clinically relevant pancreatic fistula in patients undergoing pancreatoduodenectomy
Authors: Nakamura Kota , Sho Masayuki , Kinoshita Shoichi , Akahori Takahiro , Nagai Minako , Nakagawa Kenji , Takagi Tadataka , Ikeda Naoya 
Published: June 2020

AbstractBackgroundThe association between bacterial infection and clinically relevant postoperative pancreatic fistula (CR‐POPF) after pancreatoduodenectomy (PD) has not been fully elucidated.MethodsMicrobiological data for intraoperative bile culture (BC) and drain culture on postoperative day 4 (DC) were collected. The study population was classified into the following three groups: P1 (positive BC and DC), P2 (positive BC and negative DC), and N (negative BC). A total of 209 patients (P1: 38, P2: 72, and N: 99) who underwent PD between May 2013 and May 2018 met the inclusion criteria of the study.ResultsThe rate of CR‐POPF was significantly higher in the P1 group (34.2%) than in the P2 (12.5%; P = .007) and N groups (14.1%; P = .008). Between P1 and P2 groups, a significant difference was observed in the proportion of Enterococcus faecalis grown in BC (42.1% vs 4.2%; P < .001). Multivariable logistic regression analysis showed that the presence of E faecalis in bile was independently associated with CR‐POPF.ConclusionsThe detection of both bile and postoperative abdominal fluid infections can be more accurate in predicting CR‐POPF. Furthermore, the presence of E faecalis in bile may serve as a novel surrogate marker for CR‐POPF.
Risk factors for walled‐off necrosis associated with severe acute pancreatitis: A multicenter retrospective observational study
Authors: Ikarashi Satoshi , Kawai Hirokazu , Hayashi Kazunao , Kohisa Junji , Sato Toshifumi , Nozawa Yujiro , Morita Shinichi , Oka Hiromitsu , Sato Munehiro , Aruga Yukio , Yoshikawa Seiichi , Terai Shuji 
Published: June 2020

AbstractBackgroundThis study aimed to identify the risk factors for walled‐off necrosis (WON) associated with severe acute pancreatitis (SAP).MethodsThis retrospective study was conducted in eight institutions in Japan between 2014 and 2017. We analyzed WON incidence, patient characteristics, and risk factors for WON in patients with SAP who were observed for >28 days.ResultsOf 134 patients with SAP, WON occurred in 40 (29.9%). Male sex (P = .045), body mass index (BMI) ≥25 (P < .001), post‐endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (P = .020), and disseminated intravascular coagulation (DIC) (P = .001) were more frequent in the WON group than in the non‐WON group. On admission, the frequency of white blood cell counts ≥ 12 000/µL (P = .037) and hypoenhanced pancreatic lesion on computed tomography (P = .047) were significantly higher in the WON group. In multivariate analysis, BMI ≥ 25 (odds ratio [OR] 5.73, 95% confidence interval [CI] 1.95‐16.8; P = .002), post‐ERCP (OR 8.08, 95% CI 1.57‐41.7; P = .013), and DIC (OR 3.52, 95% CI 1.20‐10.4; P = .022) were independent risk factors for WON.ConclusionsHigh BMI, post‐ERCP pancreatitis, and DIC are risk factors for the development of WON associated with SAP.
Immunosuppressive tumor microenvironment in occupational cholangiocarcinoma: Supportive evidence for the efficacy of immune checkpoint inhibitor therapy
Authors: Sato Yasunori , Tanaka Shogo , Kinoshita Masahiko , Takemura Shigekazu , Shinkawa Hiroji , Kokudo Takashi , Hasegawa Kiyoshi , Tanaka Hiromu , Yoshimoto Hidero , Mori Akira , Yamamura Minako , Sasaki Motoko , Harada Kenichi , Kubo Shoji 
Published: June 2020

AbstractBackgroundOccupational cholangiocarcinoma (CCA) was first described in patients who were working at a printing company in Osaka, Japan. Recently, the therapeutic efficacy and safety of a PD1 inhibitor nivolumab are being evaluated in patients with occupational CCA in an investigator‐initiated clinical trial. The therapeutic effects of immune checkpoint inhibitors are closely associated with immune cells.MethodsImmunohistochemical analysis was performed to characterize immune cells in the tumor microenvironment of occupational CCA. The status of mismatch repair (MMR)/microsatellite instability (MSI) was also examined.ResultsThe tumor stroma of occupational CCA was characterized by abundant infiltration of immune cells expressing CD3, CD4, CD8, CD163, FOXP3, and granzyme B. Additionally, lymphocytes expressing immune checkpoint receptors, such as PD1, CTLA4, LAG3, TIM3, and TIGIT, were frequently infiltrated. The loss of immunohistochemical expression of the MMR proteins (MLH1, MSH2, PMS2, and MSH6) was not observed in cases of occupational CCA, and MSI was not detected.ConclusionsThe tumor microenvironment of occupational CCA had features of immunosuppression, and the occurrence of T‐cell dysfunction or exhaustion was suggested. The results provide supportive evidence for the efficacy of immune checkpoint inhibitor therapy for this disease.