bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparative study of 14‐day dual therapy (esomeprazole and amoxicillin four times daily) and triple plus bismuth therapy for first‐line Helicobacter pylori infection eradication: A randomized trial
Authors: Song Zhiqiang , Zhou Liya , Xue Yan , Suo Baojun , Tian Xueli , Niu Zhanyue 
Published: October 2020

AbstractBackgroundFavorable outcomes in treating H pylori infection using “dual therapy (proton pump inhibitor and amoxicillin four times daily)” have attracted widespread attention. However, there are few reports, and the study results lack agreement. This study aimed to compare the eradication rate, safety, and compliance of naïve‐treatment patients with H pylori infection on “dual therapy” with those on “triple plus bismuth (TPB) therapy.”MethodsThis is a non‐inferior randomized controlled trial conducted on 760 patients with H pylori infection. The participants were randomly assigned to two eradication groups: dual therapy (esomeprazole 20 mg and amoxicillin 750 mg four times daily) and TPB therapy (esomeprazole 20 mg, amoxicillin 1000 mg, clarithromycin 500 mg, and bismuth potassium citrate 220 mg twice daily) for 14 days. Safety and compliance were assessed within 3 days after eradication. Urea breath test was performed about 8 weeks after eradication to evaluate outcome. Antibiotic resistance and CYP2C19 polymorphism were determined.ResultsCompared with TPB therapy, dual therapy had significantly higher eradication rates in intention‐to‐treat (87.1% vs 80.5%, rate difference 6.6%), modified intention‐to‐treat (90.9% vs 85.5%, 5.5%) and per‐protocol (92.4% vs 87.8%, 4.7%) analyses, respectively. Adverse reactions in dual therapy group were significantly lower than TPB therapy group (17.6% vs 25.5%, P = .008), and dual therapy group had better compliance (96.3% vs 92.3%, P = .019). Antibiotic resistance and poor compliance were also associated with treatment failure.ConclusionsDual therapy (esomeprazole and amoxicillin four times daily) was non‐inferior to, and even superior to TPB therapy as first‐line H pylori eradication.
Becoming a Prison Officer: An Analysis of the Early Development of Prison Officer Cultures
Authors: MORRISON KATRINA , MAYCOCK MATTHEW 
Published: October 2020

AbstractDespite the fact that over recent years, imprisonment in Scotland has adopted a bold and aspirational policy direction including proposed reforms to the role of the prison officer, there has been little research into prison officers in Scotland, and by extension, the Scottish Prison Service (SPS) as an organisation. This article offers a unique empirical insight into prison officer recruits and evolving prison officer cultures, by longitudinally tracking 31 prison officer recruits over training and early working experience. The article provides an in‐depth perspective on prison officer recruits’ views and experiences, and it also makes a contribution to the emerging area of research of the SPS through a focus on organisational change and reform. Finally, it incorporates, and further develops, a body of literature on penality and the penal state by interrogating the tensions between policy and practice within the context of the Scottish penal system.
A user‐friendly guide to the ciliates (Protozoa, Ciliophora) commonly used by hydrobiologists as bioindicators in rivers, lakes, and waste waters, with notes on their ecology
Authors: FOISSNER WILHELM , BERGER HELMUT 
Published: October 2020

SUMMARY

A user‐friendly guide to 300 ciliate species (Protozoa, Ciliophora) used as bioindicators by river, lake and waste water ecologists is provided. The guide is an English translation of the flow charts written in German and published by Foissner et al. (1991, 1992, 1994, 1995) in the Ciliate Atlas, a monograph on the ciliates used as bioindicators in the saprobic system. This guide is designed for users not specifically trained in identification of ciliates. Main groups and species are keyed dichotomously on forty‐seven flow charts using simple characters usually recognizable in live specimens. Species with conspicuous characters, e.g. large size or distinct colour, are shown on thirty‐two separate charts designated ‘special keys’. Although the flow charts give a high probability of correct species identifications, these should nevertheless be checked against the detailed figures and descriptions contained in the Ciliate Atlas.
A table with the species keyed and their main ecological characteristics (biomass, food preference, salinity tolerance, preferred occurrence, saprobiological classification) is also provided.
Typical ciliate communities found in natural and polluted habitats are briefly described and figured on thirteen plates.
A detailed systematic index is provided for all taxa mentioned in the flow charts.
circ_SEPT9, a newly identified circular RNA, promotes oral squamous cell carcinoma progression through miR‐1225/PKN2 axis
Authors: Ai Yilong , Tang Zhe , Zou Chen , Wei Haigang , Wu Siyuan , Huang Dahong 
Published: October 2020

AbstractCircular RNAs (circRNAs) represent a newly discovered class of endogenous non‐coding RNAs which are widely expressed and play important roles in disease progression. However, the function of circRNAs in oral squamous cell carcinoma (OSCC) still remains largely unknown. In this research, we found that circ_SEPT9 was highly expressed in OSCC cell lines and tumour tissues. Results showed that circ_SEPT9 promoted OSCC proliferation and tumour growth. And, circ_SEPT9 also enhanced the migration and invasion of OSCC cells. Mechanically, we found that circ_SEPT9 acted as a sponge for miR‐1225 to rescue PKN2 expression in OSCC cells. Inhibition of circ_SEPT9/miR‐1225/PKN2 pathway could effectively block the proliferation and metastasis of OSCC cells. Our study provides strong evidence that circ_SEPT9/miR‐1225/PKN2 axis is a promising target for OSCC treatment.
Missense mutations in CASK, coding for the calcium‐/calmodulin‐dependent serine protein kinase, interfere with neurexin binding and neurexin‐induced oligomerization
Authors: Pan Yingzhou Edward , Tibbe Debora , Harms Frederike Leonie , Reißner Carsten , Becker Kerstin , Dingmann Bri , Mirzaa Ghayda , Kattentidt‐Mouravieva Anja A. , Shoukier Moneef , Aggarwal Shagun , Missler Markus , Kutsche Kerstin , Kreienkamp Hans‐Jürgen 
Published: October 2020

AbstractMutations in the X‐linked gene coding for the calcium‐/calmodulin‐dependent serine protein kinase (CASK) are associated with severe neurological disorders ranging from intellectual disability (in males) to mental retardation and microcephaly with pontine and cerebellar hypoplasia. CASK is involved in transcription control, in the regulation of trafficking of the post‐synaptic NMDA and α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptors, and acts as a presynaptic scaffolding protein. For CASK missense mutations, it is mostly unclear which of CASK’s molecular interactions and cellular functions are altered and contribute to patient phenotypes. We identified five CASK missense mutations in male patients affected by neurodevelopmental disorders. These and five previously reported mutations were systematically analysed with respect to interaction with CASK interaction partners by co‐expression and co‐immunoprecipitation. We show that one mutation in the L27 domain interferes with binding to synapse‐associated protein of 97 kDa. Two mutations in the guanylate kinase (GK) domain affect binding of CASK to the nuclear factors CASK‐interacting nucleosome assembly protein (CINAP) and T‐box, brain, 1 (Tbr1). A total of five mutations in GK as well as PSD‐95/discs large/ZO‐1 (PDZ) domains affect binding of CASK to the pre‐synaptic cell adhesion molecule Neurexin. Upon expression in neurons, we observe that binding to Neurexin is not required for pre‐synaptic localization of CASK. We show by bimolecular fluorescence complementation assay that Neurexin induces oligomerization of CASK, and that mutations in GK and PDZ domains interfere with the Neurexin‐induced oligomerization of CASK. Our data are supported by molecular modelling, where we observe that the cooperative activity of PDZ, SH3 and GK domains is required for Neurexin binding and oligomerization of CASK.
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Tripeptide and hexapeptide topical as adjunct to nonablative fractional resurfacing for photodamage: A randomized split‐face trial
Authors: Wang Jordan V. , Christman Mitalee P. , Feng Hao , Ferzli Georgina , Jeon Hana , Geronemus Roy G. 
Published: October 2020

AbstractBackgroundTopical adjuncts have been investigated to improve clinical outcomes associated with laser resurfacing for photodamage and cutaneous aging. One such product is a tripeptide/hexapeptide serum, which has been shown to increase dermal collagen and elastin as well as improve postprocedural recovery following treatments.AimsA randomized, blinded, split‐face, comparative trial was performed to assess the utility of a tripeptide/hexapeptide serum as a peri‐procedural adjunct to nonablative fractional laser resurfacing.Patients/MethodsA total of 20 subjects were enrolled. Each hemiface was randomized to either tripeptide/hexapeptide serum or bland moisturizer for twice daily application starting 14 days prior to first laser treatment and continuing until 60 days after. All subjects received 2 treatments to entire face approximately 1 month apart with 1927 nm thulium nonablative fractional laser. Clinical measures and immediate postprocedural recovery were assessed.ResultsFor each hemiface, scores improved for all measures, including global photodamage, lentigines, pores, radiance, texture, and tone at 30 and 60 days. The tripeptide/hexapeptide serum had greater improvements for all measures at both time points, except for radiance at 60 days, which was equal. In cases where clinical ratings differed between sides, tripeptide/hexapeptide serum more frequently had the superior outcome. Overall, subjects were satisfied with tripeptide/hexapeptide serum. No significant adverse events were observed.ConclusionAddition of tripeptide/hexapeptide serum as a peri‐procedural adjunct to nonablative fractional laser resurfacing improved various clinical measures of photodamage and cutaneous aging and the immediate postprocedural recovery. The tripeptide/hexapeptide serum was demonstrated to be safe, well‐tolerated, and well‐liked by subjects.
Rapid colour shift by reproductive character displacement in Cupido butterflies
Authors: Hinojosa Joan C. , Koubínová Darina , Dincă Vlad , Hernández‐Roldán Juan , Munguira Miguel L. , García‐Barros Enrique , Vila Marta , Alvarez Nadir , Mutanen Marko , Vila Roger 
Published: October 2020

AbstractReproductive character displacement occurs when competition for successful breeding imposes a divergent selection on the interacting species, causing a divergence of reproductive traits. Here, we show that a disputed butterfly taxon is actually a case of male wing colour shift, apparently produced by reproductive character displacement. Using double digest restriction‐site associated DNA sequencing and mitochondrial DNA sequencing we studied four butterfly taxa of the subgenus Cupido (Lepidoptera: Lycaenidae): Cupido minimus and the taxon carswelli, both characterized by brown males and females, plus C. lorquinii and C. osiris, both with blue males and brown females. Unexpectedly, taxa carswelli and C. lorquinii were close to indistinguishable based on our genomic and mitochondrial data, despite displaying strikingly different male coloration. In addition, we report and analysed a brown male within the C. lorquinii range, which demonstrates that the brown morph occurs at very low frequency in C. lorquinii. Such evidence strongly suggests that carswelli is conspecific with C. lorquinii and represents populations with a fixed male brown colour morph. Considering that these brown populations occur in sympatry with or very close to the blue C. osiris, and that the blue C. lorquinii populations never do, we propose that the taxon carswelli could have lost the blue colour due to reproductive character displacement with C. osiris. Since male colour is important for conspecific recognition during courtship, we hypothesize that the observed colour shift may eventually trigger incipient speciation between blue and brown populations. Male colour seems to be an evolutionarily labile character in the Polyommatinae, and the mechanism described here might be at work in the wide diversification of this subfamily of butterflies.
A walk through the progression of resuscitation medicine
Authors: Shoaib Muhammad , Becker Lance B. 
Published: October 2020

AbstractCardiac arrest (CA) is a sudden and devastating disease process resulting in more deaths in the United States than many cancers, metabolic diseases, and even car accidents. Despite such a heavy mortality burden, effective treatments have remained elusive. The past century has been productive in establishing the guidelines for resuscitation, known as cardiopulmonary resuscitation (CPR), as well as developing a scientific field whose aim is to elucidate the underlying mechanisms of CA and develop therapies to save lives. CPR has been successful in reinitiating the heart after arrest, enabling a survival rate of approximately 10% in out‐of‐hospital CA. Although current advanced resuscitation methods, including hypothermia and extracorporeal membrane oxygenation, have improved survival in some patients, they are unlikely to significantly improve the national survival rate any further without a paradigm shift. Such a change is possible with sustained efforts in the basic and clinical sciences of resuscitation and their implementation. This review seeks to discuss the current landscape in resuscitation medicine—how we got here and where we are going.
Association of serum lipid parameters with the SCORAD index and onset of atopic dermatitis in children
Authors: Kim Ju Hee , Lee Seung Won , Yon Dong Keon , Ha Eun Kyo , Jee Hye Mi , Sung Myongsoon , Sim Hyeon Jeong , Yoon Jung Won , Choi Sun‐Hee , Shin Youn Ho , Seo Seung In , Baek Hey‐Sung , Han Man Yong 
Published: October 2020

AbstractBackgroundThe association between dyslipidemia and atopic dermatitis in children is unclear. This study investigated the association between dyslipidemia and atopic dermatitis in children by analysis of disease onset, risk factors, and disease severity.MethodsSubset I examined 7‐year‐old children in elementary school (n = 248), and Subset II was a retrospective long‐term follow‐up hospital‐based study (n = 52 725) conducted from 1986 to 2016 that used propensity score matching. In the Subset I study, total cholesterol (TC), high‐density lipoprotein cholesterol (HDL‐C), low‐density lipoprotein cholesterol (LDL‐C), and triglycerides (TG) were determined, and the SCORing Atopic Dermatitis (SCORAD) index was determined. In the Subset II study, the time of atopic dermatitis onset was determined for asymptomatic subjects whose TC levels were below or above 170 mg/dL.ResultsOur Subset I study indicated that children with atopic dermatitis (n = 69, 27.8%) had significantly higher levels of TC and TG, and that the SCORAD index had significant associations with high levels of TC and TG, and a low level of HDL‐C. Our Subset II study (1722 with high TC and 6735 with normal TC after propensity score matching) indicated the high TC group had a greater hazard ratio (HR) for the onset of atopic dermatitis (consensus‐based HR: 2.47; 95% CI: 1.23, 5.06, P = .012) during 5 years.ConclusionAn abnormal blood lipid profile in children is associated with the presence of atopic dermatitis and the SCORAD index. The risk of atopic dermatitis onset was significantly greater with high levels of TC.
Type I interferon signaling limits viral vector priming of CD8+ T cells during initiation of vitiligo and melanoma immunotherapy
Authors: Riding Rebecca L. , Richmond Jillian M. , Fukuda Keitaro , Harris John E. 
Published: October 2020

AbstractVitiligo is an autoimmune skin disease in which epidermal melanocytes are targeted for destruction by CD8+ T cells specific for melanocyte/melanoma‐shared antigens. IFNγ is the central cytokine driving disease, but the role of type I IFN in vitiligo remains unclear. We investigated the functional role of type I IFN during vitiligo progression using two different mouse models: one induced with a vaccinia virus (VV) vaccine and one induced with dendritic cells to prime autoimmune T cells. Induction of vitiligo by VV in IFNaR‐deficient mice led to the development of severe vitiligo compared with wild‐type (WT) mice and was characterized by a significantly enhanced effector CD8+ T‐cell response. Severe vitiligo in this model was a result of VV persistence, because exacerbation of disease in IFNaR‐deficient mice was not observed when antigen‐pulsed dendritic cells were used to induce vitiligo instead of virus. Treatment of B16F10 melanoma‐inoculated mice with VV vaccine therapy also induced a significantly enhanced anti‐tumor response in IFNaR‐deficient mice compared with WT. These results not only help define the pathways responsible for vitiligo progression but also suggest that blockade of type I IFNs following administration of a VV vaccine may provide increased immunogenicity and efficacy for melanoma immunotherapy.
Current status of the anger superiority hypothesis: A meta‐analytic review of N2pc studies
Authors: Liu Yanci , Wang Yang , Gozli Davood G. , Xiang Yu‐Tao , Jackson Todd 
Published: October 2020

AbstractNumerous investigators have tested contentions that angry faces capture early attention more completely than happy faces do in the context of other faces. However, syntheses of studies on early event‐related potentials related to the anger superiority hypothesis have yet to be conducted, particularly in relation to the N200 posterior‐contralateral (N2pc) component which provides a reliable electrophysiological index related to orienting of attention suitable for testing this hypothesis. Fifteen samples (N = 534) from 13 studies featuring the assessment of N2pc amplitudes during exposure to angry‐neutral and/or happy‐neutral facial expression arrays were included for meta‐analysis. Moderating effects of study design features and sample characteristics on effect size variability were also assessed. N2pc amplitudes elicited by affectively valenced expressions (angry and happy) were significantly more pronounced than those elicited by neutral expressions. However, the mean effect size difference between angry and happy expressions was ns. N2pc effect sizes were moderated by sample age, number of trials, and nature of facial images used (schematic vs. real) with larger effect sizes observed when samples were comparatively younger, more task trials were presented and schematic face arrays were used. N2pc results did not support anger superiority hypothesis. Instead, attentional resources allocated to angry versus happy facial expressions were similar in early stages of processing. As such, possible adaptive advantages of biases in orienting toward both anger and happy expressions warrant consideration in revisions of related theory.
The Fund for European Aid to the Most Deprived: A Trojan horse dilemma?
Authors: Greiss Johanna , Cantillon Bea , Penne Tess 
Published: October 2020

AbstractAlthough the ‘Fund for European Aid to the Most Deprived’ (FEAD) is a peripheral financing instrument with respect to European cohesion policy, it is a concrete case of a redistributive and highly targeted European anti‐poverty programme. In this sense, it is a unique supranational instrument providing social protection to European citizens, playing on the necessity of food aid in most European Union (EU) countries. With this in mind, we shed light on the Fund's budgetary scope in relation to national welfare state efforts. Also, we argue that there is some indication that FEAD could potentially contribute to shifting responsibilities from the national to the European level. For a better understanding of this phenomenon, we draw parallels to the case of the United States' Supplement Nutrition Assistance Program. We conclude that FEAD bears resemblance to a contemporary ‘Trojan horse’: it is welcomed by the Member States as a deceptively innocent EU gift but it might in the long run support the role of the EU as an agent that plugs gaps within national social protection schemes.
Contextualised resistance: The mediating power of paradigmatic frameworks
Authors: Timor‐Shlevin Shachar 
Published: October 2020

AbstractAn examination of resistance to the neoliberal dominance over public welfare organisations' operation reveals a situation of stagnation, with the call for critical resistance translated into either sporadic minor practices of isolated professionals or theoretical manifestos that demand major change, but have inadequate effect on policy. Drawing from Sanford Schram's framework of radical incrementalism as a possible challenge to neoliberal hegemony, this study traces the implementation of the Poverty‐Aware Social Work paradigm in the Israeli welfare system. Building on 16 interviews with senior agents at the Israeli Ministry of Social Affairs and Social Services, this study demonstrates the significance of this critical framework in allowing different agents to challenge the hegemonic standpoint of the Ministry. Thus, it offers a preliminary conceptualisation of contextualised resistance, which operates in the mediated sphere of power exertion, granting minor practices sufficient presence to pave the way for new opportunities for major policy change.
Lean Operation of a Pulse Detonation Combustor by Fuel Stratification
Authors: Habicht Fabian E. , Yücel Fatma C. , Hanraths Niclas , Djordjevic Neda , Paschereit Christian Oliver 
Published: October 2020

Abstract
Pressure gain combustion is a promising concept to substantially increase the thermal efficiency of gas turbines. One possible implementation that has been frequently investigated is pulse detonation combustors (PDCs), as they permit stable and reliable operation. At the same time, the need for part-load operation and low NOx emissions requires combustion concepts in the lean regime. However, realizing lean combustion is still very challenging in PDCs since the deflagration to detonation transition (DDT) is very sensitive to the reactant composition. This work investigates an approach to realize lean combustion in PDC by applying fuel stratification experimentally. The scope is to find the necessary increase of fuel concentration inside the predetonation chamber to provide reliable DDT with respect to the overall equivalence ratio. Emission measurements in the exhaust of the PDC allow for a quantification of the NOx emissions as a function of the injected fuel profile. A valveless PDC test rig is used, which contains a shock focusing geometry for detonation initiation and is ignited by a spark plug close to the upstream end wall. The subsequent expansion of the burned gas and interaction of the flame front with turbulence leads to the formation of a leading shock inside the predetonation chamber, which is then focused inside a converging-diverging geometry. The successful initiation of a detonation wave by shock focusing is very sensitive to the pressure ratio across the leading shock, which can be influenced by initial pressure, reactant composition and flow velocity. Results reveal that fuel stratification allows for reliable detonation initiation at a global equivalence ratio of φglob=0.65, whereas repeatable successful operation with nonstratified fuel injection is limited to φglob≥0.85.