bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early prediction of acute kidney injury in neonates with cardiac surgery
Authors: Shi Shanshan , Fan Jiajie , Shu Qiang 
Published: June 2020

BackgroundAcute kidney injury (AKI) occurs in 42%–64% of the neonatal patients experiencing cardiac surgery, contributing to postoperative morbidity and mortality. Current diagnostic criteria, which are mainly based on serum creatinine and hourly urine output, are not sufficiently sensitive and precise to diagnose neonatal AKI promptly. The purpose of this review is to screen the recent literature, to summarize the novel and cost-effective biomarkers and approaches for neonatal AKI after cardiac surgery (CS-AKI), and to provide a possible research direction for future work.Data sourcesWe searched PubMed for articles published before November 2019 with pertinent terms. Sixty-seven articles were found and screened. After excluding 48 records, 19 articles were enrolled for final analysis.ResultsNineteen articles were enrolled, and 18 possible urinary biomarkers were identified and evaluated for their ability to diagnose CS-AKI. Urinary neutrophil gelatinase-associated lipocalin (uNGAL), serum cystatin C (sCys), urinary human kidney injury molecule-1 (uKIM-1), urinary liver fatty acid-binding protein (uL-FABP) and interleukin-18 (uIL-18) were the most frequently described as the early predictors of neonatal CS-AKI.ConclusionsNeonates are vulnerable to CS-AKI. UNGAL, sCys, uL-FABP, uKIM-1 and uIL-18 are potential biomarkers for early prediction of neonatal CS-AKI. Renal regional oxygen saturation by near-infrared spectroscopy is a non-invasive approach for early identification of neonatal AKI. Further work should focus on exploring a sensitive and specific combined diagnostic model that includes novel biomarkers and other complementary methods.
Mass-degenerate Higgs bosons near 125 GeV in the NMSSM under current experimental constraints
Authors: Shang Liangliang , Sun Pengqiang , Heng Zhaoxia , He Yangle , Yang Bingfang 
Published: June 2020

AbstractThe observed Higgs signal at the Large Hadron Collider (LHC) may be derived from the two mass-degenerate resonances. We investigate this scenario in the Next-to-Minimal Supersymmetric Standard Model (NMSSM) in which both the two lightest CP-even Higgs bosons have masses around 125 GeV. We perform a comprehensive scan over the parameters in the NMSSM considering the current experimental constraints, especially the constraints from dark matter direct detection. The surviving samples are featured with relatively small $$\mu $$μ and large $$\tan \beta $$tanβ. The samples with large deviation of double ratios have large mixing between doublet field and singlet field.
No scalar hair behaviors of static massive scalar fields with nodes
Authors: Peng Yan 
Published: June 2020

AbstractWe study no scalar field hair behavior for spherically symmetric objects in the scalar-Gauss–Bonnet gravity. In this work, we focus on static massive scalar fields with nodes. We analytically obtain a bound on the coupling parameter. Below the bound, the static massive scalar field with nodes cannot exist outside the object. In particular, our conclusion is independent of surface boundary conditions.
On bulk viscosity at weak and strong ’t Hooft couplings
Authors: Czajka Alina , Dasgupta Keshav , Gale Charles , Jeon Sangyong , Misra Aalok , Richard Michael , Sil Karunava 
Published: June 2020

Bulk viscosity is an important transport coefficient that exists in the hydrodynamical limit only when the underlying theory is non-conformal. One example being thermal QCD with large number of colors. We study bulk viscosity in such a theory at low energies and at weak and strong ’t Hooft couplings when the temperature is above the deconfinement temperature. The weak coupling analysis is based on Boltzmann equation from kinetic theory whereas the strong coupling analysis uses non-conformal holographic techniques from string and M-theories. Using these, many properties associated with bulk viscosity may be explicitly derived.
Macrophage HIF-1α Is an Independent Prognostic Indicator in Kidney Cancer
Authors: Cowman Sophie J. , Fuja Daniel G. , Liu Xian-De , Tidwell Rebecca S. Slack , Kandula Neelima , Sirohi Deepika , Agarwal Archana M. , Emerson Lyska L. , Tripp Sheryl R. , Mohlman Jeffrey S. , Stonhill Miekan , Garcia Guillermina , Conley Christopher J. , Olalde Adam A. , Sargis Timothy , Ramirez-Torres Adela , Karam Jose A. , Wood Christopher G. , Sircar Kanishka , Tamboli Pheroze , Boucher Kenneth , Maughan Benjamin , Spike Benjamin T. , Ho Thai H. , Agarwal Neeraj , Jonasch Eric , Koh Mei Yee 
Published: June 2020

Abstract

Purpose:
Clear cell renal cell carcinoma (ccRCC) is frequently associated with inactivation of the von Hippel–Lindau tumor suppressor, resulting in activation of HIF-1α and HIF-2α. The current paradigm, established using mechanistic cell-based studies, supports a tumor promoting role for HIF-2α, and a tumor suppressor role for HIF-1α. However, few studies have comprehensively examined the clinical relevance of this paradigm. Furthermore, the hypoxia-associated factor (HAF), which regulates the HIFs, has not been comprehensively evaluated in ccRCC.

Experimental Design:
To assess the involvement of HAF/HIFs in ccRCC, we analyzed their relationship to tumor grade/stage/outcome using tissue from 380 patients, and validated these associations using tissue from 72 additional patients and a further 57 patients treated with antiangiogenic therapy for associations with response. Further characterization was performed using single-cell mRNA sequencing (scRNA-seq), RNA-in situ hybridization (RNA-ISH), and IHC.

Results:
HIF-1α was primarily expressed in tumor-associated macrophages (TAMs), whereas HIF-2α and HAF were expressed primarily in tumor cells. TAM-associated HIF-1α was significantly associated with high tumor grade and increased metastasis and was independently associated with decreased overall survival. Furthermore, elevated TAM HIF-1α was significantly associated with resistance to antiangiogenic therapy. In contrast, high HAF or HIF-2α were associated with low grade, decreased metastasis, and increased overall survival. scRNA-seq, RNA-ISH, and Western blotting confirmed the expression of HIF-1α in M2-polarized CD163-expressing TAMs.

Conclusions:
These findings highlight a potential role of TAM HIF-1α in ccRCC progression and support the reevaluation of HIF-1α as a therapeutic target and marker of disease progression.
IL15 Stimulation with TIGIT Blockade Reverses CD155-mediated NK-Cell Dysfunction in Melanoma
Authors: Chauvin Joe-Marc , Ka Mignane , Pagliano Ornella , Menna Carmine , Ding Quanquan , DeBlasio Richelle , Sanders Cindy , Hou Jiajie , Li Xian-Yang , Ferrone Soldano , Davar Diwakar , Kirkwood John M. , Johnston Robert J. , Korman Alan J. , Smyth Mark J. , Zarour Hassane M. 
Published: June 2020

Abstract

Purpose:
Natural killer (NK) cells play a critical role in tumor immunosurveillance. Multiple activating and inhibitory receptors (IR) regulate NK-cell–mediated tumor control. The IR T-cell immunoglobulin and ITIM domain (TIGIT) and its counter-receptor CD226 exert opposite effects on NK-cell–mediated tumor reactivity.

Experimental Design:
We evaluated the frequency, phenotype, and functions of NK cells freshly isolated from healthy donors and patients with melanoma with multiparameter flow cytometry. We assessed TIGIT and CD226 cell surface expression and internalization upon binding to CD155. We evaluated the role of IL15 and TIGIT blockade in increasing NK-cell–mediated cytotoxicity in vitro and in two mouse models.

Results:
NK cells are present at low frequencies in metastatic melanoma, are dysfunctional, and downregulate both TIGIT and CD226 expression. As compared with TIGIT− NK cells, TIGIT+ NK cells exhibit higher cytotoxic capacity and maturation, but paradoxically lower cytotoxicity against CD155+ MHC class I–deficient melanoma cells. Membrane bound CD155 triggers CD226 internalization and degradation, resulting in decreased NK-cell–mediated tumor reactivity. IL15 increases TIGIT and CD226 gene expression by tumor-infiltrating NK cells (TiNKs) and, together with TIGIT blockade, increases NK-cell–mediated melanoma cytotoxicity in vitro and decreases tumor metastasis in two mouse melanoma models. Specific deletion of TIGIT on transferred NK cells enhances the antimetastatic activity of IL15, while CD226 blockade decreases the effects of IL15 and TIGIT blockade.

Conclusions:
Our findings support the development of novel combinatorial immunotherapy with IL15 and TIGIT blockade to promote NK-cell–mediated destruction of MHC class I–deficient melanoma, which are refractory to CD8+ T-cell–mediated immunity.
See related commentary by Pietra et al., p. 5274
New records of nasutiform termite (Nasutitermitinae: Termitidae: Isoptera) from Meghalaya, India
Authors: Das Khirod Sankar , Choudhury Sudipta 
Published: June 2020

Termites, an important group of insects, present almost everywhere and play a vital role in the modification of their surrounding environment. This taxonomic account is a part of our study on the termite fauna of Meghalaya and deals with two new records of nasutiform termite from the state. The studied samples were identified as Hospitalitermes jepsoni Snyder, 1934 and Nasutitermes matangensis matangensis Haviland, 1898 based on the available morphological keys. The genus Hospitalitermes Holmgren, 1912 is also documented for the first time from the state. The range of the morphometrics for H. jepsoni has been revised.
, Nasutitermes matangensis matangensis, .
A record of gynandromorphism in the libellulid dragonfly Crocothemis servilia (Insecta: Odonata) from India
Authors: R.V. Renjith  , A. Vivek Chandran  
Published: June 2020

Here we report a case of gynandromorphism in the dragonfly Crocothemis servilia (Drury, 1773), (Insecta: Odonata: Anisoptera: Libellulidae) from the Puzhakkal region of Kole wetlands, Thrissur, Kerala, southern India from a single photograph recorded during a survey conducted on 14 July 2019. The individual exhibits bilateral gynandromorphism only in the thoracic region, half of which showed blood red colouration as in males and the other half pale yellow characteristic of females. The base of the wing of the red half was marked with rich amber, in contrast with the other wing base which was paler. The head, legs, and abdomen showed typical female morphology.
Additions to the cicada (Insecta: Hemiptera: Cicadidae) fauna of India: first report and range extension of four species with notes on their natural history from Meghalaya
Authors: Sarkar Vivek , Mahapatra Cuckoo , Mohapatra Pratyush P. , Nair Manoj V. 
Published: June 2020

In order to broaden our understanding about cicada diversity of northeastern India, a comprehensive survey was conducted in the year 2017, in Garo, Khasi, and Jaintia hills of Meghalaya and an occasional opportunistic survey was carried out in northern West Bengal and Arunachal Pradesh. During these surveys, we came across four species of cicadas, viz., Meimuna duffelsi, Dundubia annandalei, Balinta tenebricosa, and Orientopsaltria fangrayae, which were not reported from India earlier and among them the genus Orientopsaltria is being reported for the first time from the country. This work provides an account of the taxonomy, natural history, distribution, and acoustics of these four species of cicadas along with their attribute to the culture and customs of the indigenous tribes of the landscape.
Range extension of the Lilac Silverline Apharitis lilacinus to southern Rajasthan and a review of the literature
Authors: Sundar K.S. Gopi , Kittur Swati , Koli Vijay Kumar , Prajapati Utkarsh 
Published: June 2020

In this note we report the first sighting of the Lilac Silverline butterfly from Kumbalgarh Wildlife Sanctuary in southern Rajasthan. We also conducted a literature review of the sparse number of observations of this species to provide an updated understanding of the natural history, ecology and conservation status of this rare species.
Catheterization Laboratory Activation Time in Patients Transferred With ST-Segment–Elevation Myocardial Infarction: Insights From the Mission: Lifeline STEMI Accelerator-2 Project
Authors: Zeitouni Michel , Al-Khalidi Hussein R. , Roettig Mayme L. , Bolles Michele M. , Doerfler Shannon M. , Fordyce Christopher B. , Hellkamp Anne S. , Henry Timothy D. , Magdon-Ismail Zainab , Monk Lisa , Nelson R. Darrell , O’Brien Peter K. , Wilson B. Hadley , Ziada Khaled M. , Granger Christopher B. , Jollis James G. 
Published: June 2020

Background:
Catheterization laboratory (cath lab) activation time is a newly available process measure for patients with ST-segment–elevation myocardial infarction requiring inter-hospital transfers for primary percutaneous coronary intervention that reflects inter-facility communication and urgent mobilization of interventional laboratory resources. Our aim was to determine whether faster activation is associated with improved reperfusion time and outcomes in the American Heart Association Mission: Lifeline Accelerator-2 Project.

Methods and Results:
From April 2015 to March 2017, treatment times of 2063 patients with ST-segment–elevation myocardial infarction requiring inter-hospital transfer for primary percutaneous coronary intervention from 12 regions around the United States were stratified by cath lab activation time (first hospital arrival to cath lab activation within [timely] or beyond 20 minutes [delayed]). Median cath lab activation time was 26 minutes, with a delayed activation observed in 1241 (60.2%) patients. Prior cardiovascular or cerebrovascular disease, arterial hypotension at admission, and black or Latino ethnicity were independent factors of delayed cath lab activation. Timely cath lab activation patients had shorter door-in door-out times (40 versus 68 minutes) and reperfusion times (98 versus 135 minutes) with 80.1% treated within the national goal of ≤120 minutes versus 39.0% in the delayed group.

Conclusions:
Cath lab activation within 20 minutes across a geographically diverse group of hospitals was associated with performing primary percutaneous coronary intervention within the national goal of ≤120 minutes in >75% of patients. While several confounding factors were associated with delayed activation, this work suggests that this process measure has the potential to direct resources and practices to more timely treatment of patients requiring inter-hospital transfer for primary percutaneous coronary intervention.
Routine Revascularization Versus Initial Medical Therapy for Stable Ischemic Heart Disease
Authors: Bangalore Sripal , Maron David J. , Stone Gregg W. , Hochman Judith S. 
Published: June 2020

Background:
Revascularization is often performed in patients with stable ischemic heart disease. However, whether revascularization reduces death and other cardiovascular outcomes is uncertain.

Methods:
We conducted PUBMED/EMBASE/Cochrane Central Register of Controlled Trials searches for randomized trials comparing routine revascularization versus an initial conservative strategy in patients with stable ischemic heart disease. The primary outcome was death. Secondary outcomes were cardiovascular death, myocardial infarction (MI), heart failure, stroke, unstable angina, and freedom from angina. Trials were stratified by percent stent use and by percent statin use to evaluate outcomes in contemporary trials.

Results:
Fourteen randomized clinical trials that enrolled 14 877 patients followed up for a weighted mean of 4.5 years with 64 678 patient-years of follow-up fulfilled our inclusion criteria. Most trials enrolled patients with preserved left ventricular systolic function and low symptom burden, and excluded patients with left main disease. Revascularization compared with medical therapy alone was not associated with a reduced risk of death (relative risk [RR], 0.99 [95% CI, 0.90–1.09]). Trial sequential analysis showed that the cumulative z-curve crossed the futility boundary, indicating firm evidence for lack of a 10% or greater reduction in death. Revascularization was associated with a reduced nonprocedural MI (RR, 0.76 [95% CI, 0.67–0.85]) but also with increased procedural MI (RR, 2.48 [95% CI, 1.86–3.31]) with no difference in overall MI (RR, 0.93 [95% CI, 0.83–1.03]). A significant reduction in unstable angina (RR, 0.64 [95% CI, 0.45–0.92]) and increase in freedom from angina (RR, 1.10 [95% CI, 1.05–1.15]) was also observed with revascularization. There were no treatment-related differences in the risk of heart failure or stroke.

Conclusions:
In patients with stable ischemic heart disease, routine revascularization was not associated with improved survival but was associated with a lower risk of nonprocedural MI and unstable angina with greater freedom from angina at the expense of higher rates of procedural MI. Longer-term follow-up of trials is needed to assess whether reduction in these nonfatal spontaneous events improves long-term survival.
Multiphasic Computed Tomography Angiography Findings for Identifying Pseudo-Occlusion of the Internal Carotid Artery
Authors: Choi Jai Ho , Jang Jinhee , Koo Jaseong , Ahn Kook-Jin , Sam Shin Yong , Kim Bum-soo 
Published: June 2020

Background and Purpose:
Differentiation between pseudo-occlusion and true occlusion of internal carotid artery (ICA) is important in treatment planning for acute ischemic stroke patients. We compared the findings of multiphasic computed tomography angiography between cervical ICA pseudo-occlusion and true occlusion at the cervical ICA in patients with anterior circulation acute ischemic stroke to determine their diagnostic value.

Methods:

Thirty patients with nonvisualization of the proximal ICA were included. Diagnosis of pseudo- or true occlusion of the ICA was made based on digital subtraction angiography. Diagnostic performances of multiphasic computed tomography angiography findings—(1) a flame-shaped stump and (2) delayed contrast filling at the cervical ICA— were evaluated and compared. The Fisher exact test, χ
2
test, or Wilcoxon rank-sum test and McNemar test were used in the data analysis.

Results:

Twelve patients had true proximal ICA occlusion and 18 had pseudo-occlusion. Delayed contrast filling at the cervical ICA on multiphasic computed tomography angiography was found in all patients with pseudo-occlusion of the ICA, while 1 case of true occlusion showed delayed contrast filling (
P
<0.001). The presence of a flame-shaped stump was not significantly different between the pseudo- and true occlusion groups. The sensitivity of delayed contrast filling (0.94 [95% CI, 0.73–1]) was significantly higher than that of flame-shaped stump (0.75 [95% CI, 0.36–0.83]).

Conclusions:
We demonstrated that the delayed filling sign on multiphasic computed tomography angiography could be a useful and readily available finding for differentiating proximal ICA pseudo-occlusion from true occlusion.
Myth, Allegory and Inspired Symbolism in Early and Late Antique Platonism
Authors: Kutash Emilie 
Published: June 2020

Abstract
The idea that mythos and logos are incompatible, and that truth is a product of scientific and dialectical thinking, was certainly disproven by later Platonic philosophers. Deploying the works of Hesiod and Homer, Homeric Hymns and other such literature, they considered myth a valuable and significant augment to philosophical discourse. Plato’s denigration of myth gave his followers an incentive to read myth as allegory. The Stoics and first-century philosophers such as Philo, treated allegory as a legitimate interpretive strategy. The Middle Platonists incorporated myth, for example, deifying the Monad and Dyad, as did 2nd century Platonists. Plutarch’s Isis and Osiris (2nd century CE), for example, equates Isis and Osiris with form and matter: the god (Osiris) sows in matter (Isis) logoi (forms or ideas) from himself (De Iside. 372F). Porphyry’s allegorizing of Plato’s Cave of the Nymphs is another example. Plotinus is a strong influence on how the late Neoplatonists regarded myth. This paper argues that these philosophers’ use of allegory prepared the way for the Neoplatonists treatment of myth as inspired symbolism. Proclus and Syrianus, as reported by Hermias, did something more extreme by using mythology to construct inspired symbolic argument. Mythos becomes another type of logos, a vehicle for representing the invisible world of being, another kind of truth that can even serve a function in anagogic ascent.
Serum myonectin is increased after laparoscopic sleeve gastrectomy
Authors: Li Lei , Wang Qianqian , Qin Chengkun 
Published: June 2020

Objective Myonectin, a newly discovered myokine, enhances fatty acid uptake in cultured adipocytes and hepatocytes and suppresses circulating levels of free fatty acids in mice. Recent studies showed that serum myonectin concentration is negatively correlated with obesity. This study was undertaken to evaluate the change of serum myonectin in obese patients after laparoscopic sleeve gastrectomy. Methods This study was performed in a population of 42 obese and 58 control subjects from April of 2018 to December of 2019. All obese subjects underwent laparoscopic sleeve gastrectomy. Anthropometric measurements, lipid profiles, HbA1c and serum myonectin were assessed at baseline and six months after laparoscopic sleeve gastrectomy. Results Serum myonectin concentrations were significantly lower in the obese patients than in the controls. Serum myonectin concentrations were increased at six months after laparoscopic sleeve gastrectomy. Simple linear regression analysis indicated that serum myonectin was negatively correlated with weight, waist circumference, hip circumference, body mass index, fasting plasma glucose, homeostasis model assessment of insulin resistance and HbA1c. Only body mass index was still inversely correlated with serum myonectin after multiple linear regression analysis. Conclusion Serum myonectin is correlated with obesity and increased after laparoscopic sleeve gastrectomy.
Remodeler sa vie® (Lifestyle Redesign) : première étude pilote auprès d’aînés franco-canadiens
Authors: Lévesque Marie-Hélène , Trépanier Jordane , Tardif Marie-Ève , Lalanne Kevin , Boudriau Mélanie , Ainsley Sarah , Boislard Charles , Levasseur Mélanie 
Published: June 2020

Description. Récemment traduit et adapté au contexte franco-canadien, le programme Remodeler sa vie ( Lifestyle Redesign) vise le développement de modes de vie sains et porteurs de sens. On connaît toutefois peu l’influence de ce programme chez les aînés francophones. But. Décrire l’influence du programme Remodeler sa vie sur l’équilibre de vie, l’engagement dans les activités signifiantes, la compassion et la gratitude d’aînés franco-canadiens. Méthodologie. Une étude pilote mixte (préexpérimental et qualitatif clinique) a été réalisée auprès de 16 aînés répartis en deux groupes (avec et sans incapacités). Des questionnaires pré et post-intervention ainsi que des entretiens semi-dirigés ont été complétés. Résultats. Une augmentation de l’équilibre de vie de l’ensemble participants ( p = 0,03) et de l’engagement dans des activités signifiantes des aînés sans incapacité ( p = 0,02) a été observée. Les participants rapportaient des améliorations pour l’ensemble des résultantes. Conséquences. Remodeler sa vie est un programme prometteur pour promouvoir la santé des aînés franco-canadiens.