bluuebunny/crossref_metadata_2025_split huggingface dataset:
Provider visual attention on a respiratory function monitor during neonatal resuscitation
Authors: Herrick Heidi , Weinberg Danielle , Cecarelli Charlotte , Fishman Claire E , Newman Haley , den Boer Maria C , Martherus Tessa , Katz Trixie A , Nadkarni Vinay , te Pas Arjan B , Foglia Elizabeth E 
Published: July 2020

BackgroundA respiratory function monitor (RFM) provides real-time positive pressure ventilation feedback. Whether providers use RFM during neonatal resuscitation is unknown.MethodsAncillary study to the MONITOR(NCT03256578) randomised controlled trial. Neonatal resuscitation leaders at two centres wore eye-tracking glasses, and visual attention (VA) patterns were compared between RFM-visible and RFM-masked groups.Results14 resuscitations (6 RFM-visible, 8 RFM-masked) were analysed. The median total gaze duration on the RFM was significantly higher with a visible RFM (29% vs 1%, p<0.01), while median total gaze duration on other physical objects was significantly lower with a visible RFM (3% vs 8%, p=0.02). Median total gaze duration on the infant was lower with RFM visible, although not statistically significantly (29% vs 46%, p=0.05).ConclusionProviders’ VA patterns differed during neonatal resuscitation when the RFM was visible, emphasising the importance of studying the impact of additional delivery room technology on providers’ behaviour.
Who sells tobacco, who stops? A comparison across different tobacco retailing schemes
Authors: Burton Suzan , Phillips Fiona , Watts Christina , Kennington Kelly , Scollo Michelle , Lindorff Kylie , Egger Sam 
Published: July 2020

BackgroundLicensing of tobacco retailers has been proposed as a mechanism to encourage retailers to stop selling tobacco. However, previous studies of tobacco licensing and/or of retailers who have stopped selling have been restricted to one legislative environment. This study examines patterns of tobacco retailing across three legislative environments with three different licensing schemes (an annual fee-based licence, a zero-cost, one-off notification scheme and no notification/licensing scheme).MethodA telephone survey was conducted of 2928 potential tobacco retailers who could personally choose whether or not to sell tobacco (rather than the decision being made at a head office).ResultsUnexpectedly, the annual licence fee to sell tobacco was not significantly associated with a lower rate of selling tobacco or a higher rate of stopping. After allowing for other factors, probability of selling, stopping selling and reported importance of tobacco sales varied across outlet types (p<0.001 for all three outcomes), and according to the remoteness of the retailer (p<0.001, p trend=0.041 and p=0.025 respectively).ConclusionA fee of $A286 was not associated with a lower rate of selling, or a higher rate of stopping. The effect of licensing on retailer numbers will presumably be greater for higher licence fees, but will also depend on the perceived importance of tobacco sales to the retailer. In turn, importance of tobacco sales appears to depend on market factors, including proximity to major urban centres and low-cost competitors. A higher licence fee is likely to have a larger effect on discouraging retailers from selling.
The transverse momentum spectrum of low mass Drell–Yan production at next-to-leading order in the parton branching method
Authors: Martinez A. Bermudez , Connor P. L. S. , Damiani D. Dominguez , Banos L. I. Estevez , Hautmann F. , Jung H. , Lidrych J. , Lelek A. , Mendizabal M. , Schmitz M. , Monfared S. Taheri , Wang Q. , Wening T. , Yang H. , Žlebčík R. 
Published: July 2020

Abstract
It has been observed in the literature that measurements of low-mass Drell–Yan (DY) transverse momentum spectra at low center-of-mass energies $$\sqrt{s}$$s are not well described by perturbative QCD calculations in collinear factorization in the region where transverse momenta are comparable with the DY mass. We examine this issue from the standpoint of the Parton Branching (PB) method, combining next-to-leading-order (NLO) calculations of the hard process with the evolution of transverse momentum dependent (TMD) parton distributions. We compare our predictions with experimental measurements at low DY mass, and find very good agreement. In addition we use the low mass DY measurements at low $$\sqrt{s}$$s to determine the width $$q_s$$qs of the intrinsic Gauss distribution of the PB-TMDs at low evolution scales. We find values close to what has earlier been used in applications of PB-TMDs to high-energy processes at the Large Hadron Collider (LHC) and HERA. We find that at low DY mass and low $$\sqrt{s}$$s even in the region of $$p_\mathrm{T}/m_\mathrm{DY}\sim 1$$pT/mDY∼1 the contribution of multiple soft gluon emissions (included in the PB-TMDs) is essential to describe the measurements, while at larger masses ($$m_\mathrm{DY}\sim m_{{\mathrm{Z}}}$$mDY∼mZ) and LHC energies the contribution from soft gluons in the region of $$p_\mathrm{T}/m_\mathrm{DY}\sim 1$$pT/mDY∼1 is small.
The Hamiltonian dynamics of Hořava gravity
Authors: Devecioğlu Deniz O. , Park Mu-In 
Published: July 2020

AbstractWe consider the Hamiltonian formulation of Hořava gravity in arbitrary dimensions, which has been proposed as a renormalizable gravity model for quantum gravity without the ghost problem. We study the full constraint analysis of the non-projectable Hořava gravity whose potential, $$\mathcal{V}(R)$$V(R), is an arbitrary function of the (intrinsic) Ricci scalar R but without the extension terms which depend on the proper acceleration $$a_i$$ai. We find that there exist generally three distinct cases of this theory, A, B, and C, depending on (i) whether the Hamiltonian constraint generates new (second-class) constraints or just fixes the associated Lagrange multipliers, or (ii) whether the IR Lorentz-deformation parameter $${\lambda }$$λ is at the conformal point or not. It is found that, for Cases A and C, the dynamical degrees of freedom are the same as in general relativity, while, for Case B, there is one additional phase-space degree of freedom, representing an extra (odd) scalar graviton mode. This would achieve the dynamical consistency of a restricted model at the fully non-linear level and be a positive result in resolving the long-standing debates about the extra graviton modes of the Hořava gravity. Several exact solutions are also studied as some explicit examples of the new constraints. The structure of the newly obtained, “extended” constraint algebra seems to be generic to Hořava gravity and its general proof would be a challenging problem. Some other challenging problems, which include the path integral quantization and the Dirac bracket quantization are discussed also.
Deforming charged black holes with dipolar differential rotation boundary
Authors: Hu Tong-Tong , Sun Shuo , Li Hong-Bo , Wang Yong-Qiang 
Published: July 2020

AbstractMotivated by the recent studies of the novel asymptotically global$$\hbox {AdS}_4$$AdS4black hole with deformed horizon, we consider the action of Einstein–Maxwell gravity in AdS spacetime and construct the charged deforming AdS black holes with differential boundary. In contrast to deforming black hole without charge, there exists at least one value of horizon for an arbitrary temperature. The extremum of temperature is determined by chargeqand divides the range of temperature into several parts. Moreover, we use an isometric embedding in the three-dimensional space to investigate the horizon geometry. The entropy and quasinormal modes of deforming charged AdS black hole are also studied in this paper. Due to the existence of chargeq, the phase diagram of entropy is more complicated. We consider two cases of solutions: (1) fixing the chemical potential$$\mu $$μ; (2) changing the value of$$\mu $$μaccording to the values of horizon radius and charge. In the first case, it is interesting to find there exist two families of black hole solutions with different horizon radii for a fixed temperature, but these two black holes have same horizon geometry and entropy. The second case ensures that deforming charged AdS black hole solutions can reduce to standard RN–AdS black holes.
Increasing Penetration of DERs in Smart Grid Framework: A State-of-the-Art Review on Challenges, Mitigation Techniques and Role of Smart Inverters
Authors: Wankhede Sumeet Kumar , Paliwal Priyanka , Kirar Mukesh K. 
Published: July 2020

The world is witnessing a transformation from the conventional electrical grid into the smart grid. The smart grid can provide an effective solution to alarming problems associated with a conventional grid with increased reliability, efficiency, and sustainability. Integration of distributed energy resources (DERs) comprising of renewable energy sources (RESs) is a vital component of the smart grid. DERs not only can provide a viable solution for environmental concerns arising due to conventional fossil fuel-based plants, but can also contribute towards the system reliability. However, the integration of DERs is associated with several challenges. Thus, the successful deployment of DERs in smart grid framework calls for a comprehensive analysis. This paper presents an exhaustive review of various challenges associated with increased penetration of DERs. An organized classification of various technical challenges along with their mitigation measures has been critically reviewed. Smart inverters equipped with advanced control structure are emerging as a potential solution to address these challenges effectively. Hence, a review of smart inverter along with its functional capabilities has also been discussed in this paper.
First-in-Human Study of AT13148, a Dual ROCK-AKT Inhibitor in Patients with Solid Tumors
Authors: McLeod Robert , Kumar Rajiv , Papadatos-Pastos Dionysis , Mateo Joaquin , Brown Jessica S. , Garces Alvaro H. Ingles , Ruddle Ruth , Decordova Shaun , Jueliger Simone , Ferraldeschi Roberta , Maiques Oscar , Sanz-Moreno Victoria , Jones Paul , Traub Stephanie , Halbert Gavin , Mellor Sarah , Swales Karen E. , Raynaud Florence I. , Garrett Michelle D. , Banerji Udai 
Published: July 2020

Abstract

Purpose:
AT13148 is an oral AGC kinase inhibitor, which potently inhibits ROCK and AKT kinases. In preclinical models, AT13148 has been shown to have antimetastatic and antiproliferative activity.

Patients and Methods:
The trial followed a rolling six design during dose escalation. An intrapatient dose escalation arm to evaluate tolerability and a biopsy cohort to study pharmacodynamic effects were later added. AT13148 was administered orally three days a week (Mon–Wed–Fri) in 28-day cycles. Pharmacokinetic profiles were assessed using mass spectrometry and pharmacodynamic studies included quantifying p-GSK3β levels in platelet-rich plasma (PRP) and p-cofilin and p-MLC2 levels in tumor biopsies.

Results:
Fifty-one patients were treated on study. The safety of 5–300 mg of AT13148 was studied. Further, the doses of 120–180–240 mg were studied in an intrapatient dose escalation cohort. The dose-limiting toxicities included hypotension (300 mg), pneumonitis, and elevated liver enzymes (240 mg), and skin rash (180 mg). The most common side effects were fatigue, nausea, headaches, and hypotension. On the basis of tolerability, 180 mg was considered the maximally tolerated dose. At 180 mg, mean Cmax and AUC were 400 nmol/L and 13,000 nmol/L/hour, respectively. At 180 mg, ≥50% reduction of p-cofilin was observed in 3 of 8 posttreatment biopsies.

Conclusions:
AT13148 was the first dual potent ROCK-AKT inhibitor to be investigated for the treatment of solid tumors. The narrow therapeutic index and the pharmacokinetic profile led to recommend not developing this compound further. There are significant lessons learned in designing and testing agents that simultaneously inhibit multiple kinases including AGC kinases in cancer.
Glutamyl-Prolyl-tRNA Synthetase Regulates Proline-Rich Pro-Fibrotic Protein Synthesis During Cardiac Fibrosis
Authors: Wu Jiangbin , Subbaiah Kadiam C. Venkata , Xie Li Huitong , Jiang Feng , Khor Eng-Soon , Mickelsen Deanne , Myers Jason R. , Tang Wai Hong Wilson , Yao Peng 
Published: July 2020

Rationale:
Increased protein synthesis of profibrotic genes is a common feature in cardiac fibrosis and heart failure. Despite this observation, critical factors and molecular mechanisms for translational control of profibrotic genes during cardiac fibrosis remain unclear.

Objective:
To investigate the role of a bifunctional ARS (aminoacyl-tRNA synthetase), EPRS (glutamyl-prolyl-tRNA synthetase) in translational control of cardiac fibrosis.

Methods and Results:

Results from reanalyses of multiple publicly available data sets of human and mouse heart failure, demonstrated that EPRS acted as an integrated node among the ARSs in various cardiac pathogenic processes. We confirmed that EPRS was induced at mRNA and protein levels (≈1.5–2.5-fold increase) in failing hearts compared with nonfailing hearts using our cohort of human and mouse heart samples. Genetic knockout of one allele of
Eprs
globally (
Eprs
+/−
) using CRISPR-Cas9 technology or in a Postn-Cre-dependent manner (
Eprs
flox/+
;
Postn
MCM/+
) strongly reduces cardiac fibrosis (≈50% reduction) in isoproterenol-, transverse aortic constriction-, and myocardial infarction (MI)-induced heart failure mouse models. Inhibition of EPRS using a PRS (prolyl-tRNA synthetase)-specific inhibitor, halofuginone, significantly decreases translation efficiency (TE) of proline-rich collagens in cardiac fibroblasts as well as TGF-β (transforming growth factor-β)-activated myofibroblasts. Overexpression of EPRS increases collagen protein expression in primary cardiac fibroblasts under TGF-β stimulation. Using transcriptome-wide RNA-Seq and polysome profiling-Seq in halofuginone-treated fibroblasts, we identified multiple novel Pro-rich genes in addition to collagens, such as Ltbp2 (latent TGF-β-binding protein 2) and Sulf1 (sulfatase 1), which are translationally regulated by EPRS. SULF1 is highly enriched in human and mouse myofibroblasts. In the primary cardiac fibroblast culture system, siRNA-mediated knockdown of SULF1 attenuates cardiac myofibroblast activation and collagen deposition. Overexpression of SULF1 promotes TGF-β-induced myofibroblast activation and partially antagonizes anti-fibrotic effects of halofuginone treatment.

Conclusions:
Our results indicate that EPRS preferentially controls translational activation of proline codon rich profibrotic genes in cardiac fibroblasts and augments pathological cardiac remodeling.

Graphical Abstract:
A graphical abstract is available for this article.
First‐Trimester Maternal Folic Acid Supplementation Reduced Risks of Severe and Most Congenital Heart Diseases in Offspring: A Large Case‐Control Study
Authors: Qu Yanji , Lin Shao , Zhuang Jian , Bloom Michael S. , Smith Maggie , Nie Zhiqiang , Mai Jinzhuang , Ou Yanqiu , Wu Yong , Gao Xiangmin , Tan Hongzhuan , Liu Xiaoqing 
Published: July 2020

Background
Maternal folic acid supplementation (FAS) reduces the risk of neural tube defects in offspring. However, its effect on congenital heart disease (CHDs), especially on the severe ones remains uncertain. This study aimed to assess the individual and joint effect of first‐trimester maternal FAS and multivitamin use on CHDs in offspring.

Methods and Results

This is a case‐control study including 8379 confirmed CHD cases and 6918 controls from 40 healthcare centers of 21 cities in Guangdong Province, China. Adjusted odds ratios (aORs) of FAS and multivitamin use between CHD cases (overall and specific CHD phenotypes) and controls were calculated by controlling for parental confounders. The multiplicative interaction effect of FAS and multivitamin use on CHDs was estimated. A significantly protective association was detected between first‐trimester maternal FAS and CHDs among offspring (aOR, 0.69; 95% CI, 0.62–0.76), but not for multivitamin use alone (aOR, 1.42; 95% CI, 0.73–2.78). There was no interaction between FAS and multivitamin use on CHDs (
P
=0.292). Most CHD phenotypes benefited from FAS (aORs ranged from 0.03–0.85), especially the most severe categories (ie, multiple critical CHDs [aOR, 0.16; 95% CI, 0.12–0.22]) and phenotypes (ie, single ventricle [aOR, 0.03; 95% CI, 0.004–0.21]).

Conclusions
First‐trimester maternal FAS, but not multivitamin use, was substantially associated with lower risk of CHDs, and the association was strongest for the most severe CHD phenotypes. We recommend that women of childbearing age should supplement with folic acid as early as possible, ensuring coverage of the critical window for fetal heart development to prevent CHDs.
Alteplase for Acute Ischemic Stroke in Patients Aged >80 Years
Authors: Bluhmki Erich , Danays Thierry , Biegert Gabriele , Hacke Werner , Lees Kennedy R. 
Published: July 2020

Background/Purpose:
Expert guidelines specify no upper age limit for alteplase for thrombolysis of acute ischemic stroke (AIS) but, until recently, European regulatory criteria restricted its use to patients aged 18 to 80 years. We performed pooled analyses of randomized controlled trial (RCT) and registry data to evaluate the benefit-risk profile of alteplase for AIS among patients aged >80 years to support a regulatory application to lift the upper age restriction.

Methods:
Individual patient data were evaluated from 7 randomized trials of alteplase (0.9 mg/kg) versus placebo or open control for AIS, and the European SITS-UTMOST registry database. Clinical outcomes, including good functional outcome (score 0–1, modified Rankin Scale day 90 or Oxford Handicap Score day 180), were evaluated in the full RCT and registry populations, and specified age-based subgroups (≤80 or >80 years) who met existing European regulatory criteria for alteplase, excluding upper age restriction.

Results:

Regardless of treatment allocation, 90-day mortality was lower among RCT patients aged ≤80 versus >80 years who otherwise met existing European regulatory criteria (246/2405 [10.2%] versus 307/1028 [29.9%], respectively). Among patients aged >80 years, alteplase versus placebo was associated with a higher proportion of good stroke outcome (modified Rankin Scale score 0–1; 99/518 [19.1%] versus 67/510 [13.1%];
P
=0.0109) and similar 90-day mortality (153/518 [29.5%] versus 154/510 [30.2%];
P
=0.8382). The odds of a good stroke outcome following alteplase allocation in the full RCT population were independent of age (
P
=0.7383). Good stroke outcome was reported for almost half (4821/11 169 [43.2%]) of the patients who received alteplase in routine practice. Outcomes in routine practice supported those achieved in RCTs.

Conclusions:
Alteplase for AIS has a positive benefit-risk profile among patients aged >80 years when administered according to other regulatory criteria. Alteplase for AIS should be evaluated on an individual benefit-risk basis.
Irony and Metapoetics in Theocritus’ Idyll 18
Authors: Walker Guy 
Published: July 2020

Abstract
Although scholarship has identified multiple ironic elements throughout Theocritus’ Idyll 18, his epithalamium for Helen, this paper offers a new perspective on Theocritus’ ambiguity, his allusive puns, and his ironic comparisons that masquerade as generic hymeneal topoi. Additionally, the embedded aetiology of Helen’s tree-cult has long eluded interpretation. This paper proposes a metapoetic reading for the plane-tree and its arboreal inscription. As a mise en abyme, it forms a metatextual link between the imagined internal reader and the external audience to reflect on the power of the author and the text over the reader.
Cochlear Implantation as a Treatment for Sudden Autoimmune Sensorineural Hearing Loss in a Patient Affected by Eosinophilic Granulomatosis with Polyangiitis: A Case Report and A Review of Literature
Authors: Cacco Tommaso , Castello Eolo , Canevari Frank Rikki Mauritz , Laborai Andrea , Grillone Alessandra , Zanetti Diego , Peretti Giorgio 
Published: July 2020

Objective: To report presentation, diagnostic process, management and outcome of a case of autoimmune inner ear disease (AIED) related with Churg-Strauss syndrome, also known as eosinophilic granulomatosis with polyangiitis (EGPA), treated with cochlear implantation, and review of relevant literature. Case presentation and management: A retrospective case report of AIED associated with EGPA treated with cochlear implantation was described. A multi-step approach for diagnosis and confirmation of AIED and hearing rehabilitation was conducted, eventually leading to left cochlear implantation. Results: The surgery was without complications and postoperative course was uneventful. Two years after surgery, pure-tone and speech soundfield audiometry with left cochlear implant switched on showed a good improvement in pure-tone threshold and a word recognition score of 50% at 60 dB nHL. Literature review does not report any previous case of AIED EGPA-related. Conclusions: Cochlear implantation in AIED EGPA-related have been shown to be a viable treatment option in a stabilized phase of disease.
The importance of sociodemographic characteristics of psychotherapy patients in institutional conditions on the Balkan territory
Authors: Vezmar Milica , Colovic Olga , Meskovic Daniel , Paunovic Marina , Dukanac Vesna 
Published: July 2020

Objectives: The effects of psychotherapy are proven, compelling and far-reaching. The aim was to evaluate sociodemographic characteristics and clinical diagnosis of psychotherapeutic patients who were treated at the Institute of Mental Health in Belgrade. Design and Methods: Retrospective clinical study was composed of 334 patients. Patients data related to the gender, age, education, employment, marital status and clinical diagnose were processed by descriptive statistics methods and chi-square test. Results: Psychotherapy services were mostly used by female patients (64.1%), aged 30 to 39 years, majority finished secondary school (47.6%) and were employed (54.8%). Half of the patients were single (49.7%) with unipolar depressive non-psychotic disorder (60.5%). Conclusions: The research of this kind and with this volume of patients, coming from institutional conditions, has never been done among Balkan nationalities and thus represent encouragement for future studies.