bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrodiction beyond the Heisenberg uncertainty relation
Authors: Bao Han , Jin Shenchao , Duan Junlei , Jia Suotang , Mølmer Klaus , Shen Heng , Xiao Yanhong 
Published: November 2020

AbstractIn quantum mechanics, the Heisenberg uncertainty relation presents an ultimate limit to the precision by which one can predict the outcome of position and momentum measurements on a particle. Heisenberg explicitly stated this relation for the prediction of “hypothetical future measurements”, and it does not describe the situation where knowledge is available about the system both earlier and later than the time of the measurement. Here, we study what happens under such circumstances with an atomic ensemble containing 1011 rubidium atoms, initiated nearly in the ground state in the presence of a magnetic field. The collective spin observables of the atoms are then well described by canonical position and momentum observables, $${\hat{x}}_{\text{A}}$$

x

̂

A

and $${\hat{p}}_{\text{A}}$$

p

̂

A

that satisfy $$[{\hat{x}}_{\text{A}},{\hat{p}}_{\text{A}}]=i\hslash$$

[

x

̂

A

,

p

̂

A

]

=
i
ℏ
. Quantum non-demolition measurements of $${\hat{p}}_{\text{A}}$$

p

̂

A

before and of $${\hat{x}}_{\text{A}}$$

x

̂

A

after time t allow precise estimates of both observables at time t. By means of the past quantum state formalism, we demonstrate that outcomes of measurements of both the $${\hat{x}}_{\text{A}}$$

x

̂

A

and $${\hat{p}}_{A}$$

p

̂

A

observables can be inferred with errors below the standard quantum limit. The capability of assigning precise values to multiple observables and to observe their variation during physical processes may have implications in quantum state estimation and sensing.
Carbon Monitor, a near-real-time daily dataset of global CO2 emission from fossil fuel and cement production
Authors: Liu Zhu , Ciais Philippe , Deng Zhu , Davis Steven J. , Zheng Bo , Wang Yilong , Cui Duo , Zhu Biqing , Dou Xinyu , Ke Piyu , Sun Taochun , Guo Rui , Zhong Haiwang , Boucher Olivier , Bréon François-Marie , Lu Chenxi , Guo Runtao , Xue Jinjun , Boucher Eulalie , Tanaka Katsumasa , Chevallier Frédéric 
Published: November 2020

AbstractWe constructed a near-real-time daily CO2 emission dataset, the Carbon Monitor, to monitor the variations in CO2 emissions from fossil fuel combustion and cement production since January 1, 2019, at the national level, with near-global coverage on a daily basis and the potential to be frequently updated. Daily CO2 emissions are estimated from a diverse range of activity data, including the hourly to daily electrical power generation data of 31 countries, monthly production data and production indices of industry processes of 62 countries/regions, and daily mobility data and mobility indices for the ground transportation of 416 cities worldwide. Individual flight location data and monthly data were utilized for aviation and maritime transportation sector estimates. In addition, monthly fuel consumption data corrected for the daily air temperature of 206 countries were used to estimate the emissions from commercial and residential buildings. This Carbon Monitor dataset manifests the dynamic nature of CO2 emissions through daily, weekly and seasonal variations as influenced by workdays and holidays, as well as by the unfolding impacts of the COVID-19 pandemic. The Carbon Monitor near-real-time CO2 emission dataset shows a 8.8% decline in CO2 emissions globally from January 1st to June 30th in 2020 when compared with the same period in 2019 and detects a regrowth of CO2 emissions by late April, which is mainly attributed to the recovery of economic activities in China and a partial easing of lockdowns in other countries. This daily updated CO2 emission dataset could offer a range of opportunities for related scientific research and policy making.
Re-irradiation of recurrent glioblastoma using helical TomoTherapy with simultaneous integrated boost: preliminary considerations of treatment efficacy
Authors: Arpa Donatella , Parisi Elisabetta , Ghigi Giulia , Savini Alessandro , Colangione Sarah Pia , Tontini Luca , Pieri Martina , Foca Flavia , Polico Rolando , Tesei Anna , Sarnelli Anna , Romeo Antonino 
Published: November 2020

AbstractAlthough there is still no standard treatment for recurrent glioblastoma multiforme (rGBM), re-irradiation could be a therapeutic option. We retrospectively evaluated the efficacy and safety of re-irradiation using helical TomoTherapy (HT) with a simultaneous integrated boost (SIB) technique in patients with rGBM. 24 patients with rGBM underwent HT-SIB. A total dose of 20 Gy was prescribed to the Flair (fluid-attenuated inversion recovery) planning tumor volume (PTV) and 25 Gy to the PTV-boost (T1 MRI contrast enhanced area) in 5 daily fractions to the isodose of 67% (maximum dose within the PTV-boost was 37.5 Gy). Toxicity was evaluated by converting the 3D-dose distribution to the equivalent dose in 2 Gy fractions on a voxel-by-voxel basis. Median follow-up after re-irradiation was 27.8 months (range 1.6–88.5 months). Median progression-free survival (PFS) was 4 months (95% CI 2.0–7.9 months), while 6-month PFS was 41.7% (95% CI 22.2–60.1 months). Median overall survival following re-irradiation was 10.7 months (95% CI 7.4–16.1 months). There were no cases of re-operation due to early or late toxicity. Our preliminary results suggest that helical TomoTherapy with the proposed SIB technique is a safe and feasible treatment option for patients with rGBM, including those large disease volumes, reducing toxicity.
Kisspeptin-1 regulates forebrain dopaminergic neurons in the zebrafish
Authors: Abdul Satar Nurul M. , Ogawa Satoshi , Parhar Ishwar S. 
Published: November 2020

AbstractThe habenula is a phylogenetically conserved epithalamic structure, which conveys negative information via inhibition of mesolimbic dopamine neurons. We have previously shown the expression of kisspeptin (Kiss1) in the habenula and its role in the modulation of fear responses in the zebrafish. In this study, to investigate whether habenular Kiss1 regulates fear responses via dopamine neurons in the zebrafish, Kiss1 peptides were intracranially administered close to the habenula, and the expression of dopamine-related genes (th1, th2 and dat) were examined in the brain using real-time PCR and dopamine levels using LC–MS/MS. th1 mRNA levels and dopamine levels were significantly increased in the telencephalon 24-h and 30-min after Kiss1 administration, respectively. In fish administered with Kiss1, expression of neural activity marker gene, npas4a and kiss1 gene were significantly decreased in the ventral habenula. Application of neural tracer into the median raphe, site of habenular Kiss1 neural terminal projections showed tracer-labelled projections in the medial forebrain bundle towards the telencephalon where dopamine neurons reside. These results suggest that Kiss1 negatively regulates its own neuronal activity in the ventral habenula via autocrine action. This, in turn affects neurons of the median raphe via interneurons, which project to the telencephalic dopaminergic neurons.
Assessing the protective effects of different surface coatings on NaYF4:Yb3+, Er3+ upconverting nanoparticles in buffer and DMEM
Authors: Saleh Maysoon I. , Rühle Bastian , Wang Shu , Radnik Jörg , You Yi , Resch-Genger Ute 
Published: November 2020

AbstractWe studied the dissolution behavior of β NaYF4:Yb(20%), Er(2%) UCNP of two different sizes in biologically relevant media i.e., water (neutral pH), phosphate buffered saline (PBS), and Dulbecco’s modified Eagle medium (DMEM) at different temperatures and particle concentrations. Special emphasis was dedicated to assess the influence of different surface functionalizations, particularly the potential of mesoporous and microporous silica shells of different thicknesses for UCNP stabilization and protection. Dissolution was quantified electrochemically using a fluoride ion selective electrode (ISE) and by inductively coupled plasma optical emission spectrometry (ICP OES). In addition, dissolution was monitored fluorometrically. These experiments revealed that a thick microporous silica shell drastically decreased dissolution. Our results also underline the critical influence of the chemical composition of the aqueous environment on UCNP dissolution. In DMEM, we observed the formation of a layer of adsorbed molecules on the UCNP surface that protected the UCNP from dissolution and enhanced their fluorescence. Examination of this layer by X-ray photoelectron spectroscopy (XPS) and mass spectrometry (MS) suggested that mainly phenylalanine, lysine, and glucose are adsorbed from DMEM. These findings should be considered in the future for cellular toxicity studies with UCNP and other nanoparticles and the design of new biocompatible surface coatings.
Nucleobase morpholino β amino acids as molecular chimeras for the preparation of photoluminescent materials from ribonucleosides
Authors: Bucci Raffaella , Bossi Alberto , Erba Emanuela , Vaghi Francesco , Saha Abhijit , Yuran Sivan , Maggioni Daniela , Gelmi Maria Luisa , Reches Meital , Pellegrino Sara 
Published: November 2020

AbstractBioinspired smart materials represent a tremendously growing research field and the obtainment of new building blocks is at the molecular basis of this technology progress. In this work, colloidal materials have been prepared in few steps starting from ribonucleosides. Nucleobase morpholino β-amino acids are the chimera key intermediates allowing Phe–Phe dipeptides’ functionalization with adenine and thymine. The obtained compounds self-aggregate showing enhanced photoluminescent features, such as deep blue fluorescence and phosphorescence emissions.
Machine learning and serving of discrete field theories
Authors: Qin Hong 
Published: November 2020

AbstractA method for machine learning and serving of discrete field theories in physics is developed. The learning algorithm trains a discrete field theory from a set of observational data on a spacetime lattice, and the serving algorithm uses the learned discrete field theory to predict new observations of the field for new boundary and initial conditions. The approach of learning discrete field theories overcomes the difficulties associated with learning continuous theories by artificial intelligence. The serving algorithm of discrete field theories belongs to the family of structure-preserving geometric algorithms, which have been proven to be superior to the conventional algorithms based on discretization of differential equations. The effectiveness of the method and algorithms developed is demonstrated using the examples of nonlinear oscillations and the Kepler problem. In particular, the learning algorithm learns a discrete field theory from a set of data of planetary orbits similar to what Kepler inherited from Tycho Brahe in 1601, and the serving algorithm correctly predicts other planetary orbits, including parabolic and hyperbolic escaping orbits, of the solar system without learning or knowing Newton’s laws of motion and universal gravitation. The proposed algorithms are expected to be applicable when the effects of special relativity and general relativity are important.
Effect and mechanism of human umbilical cord mesenchymal stem cells in treating allergic rhinitis in mice
Authors: Kan Xiao-li , Pan Xing-hua , Zhao Jing , He Jie , Cai Xue-min , Pang Rong-qing , Zhu Xiang-qing , Cao Xian-bao , Ruan Guang-ping 
Published: November 2020

AbstractA model of allergic rhinitis (AR) in BALB/c mice was established and evaluated to provide experimental subjects for further research. Preparation of human umbilical cord mesenchymal stem cells (hUCMSCs), including isolation, expansion culture, passaging, cryopreservation, and preparation of cell suspensions, provided materials for experimental research and clinical treatment. The mouse AR model was established by ovalbumin (OVA) intraperitoneal injection and the nasal stimulation induction method, and the model had a good effect and high repeatability. GFP-labeled hUCMSCs had good effects and were stable cells that could be used for tracking in animals. Transplantation of hUCMSCs by intraperitoneal and tail vein injections had a specific effect on the AR model of mice, and tail vein injection had a better effect. Tracking of hUCMSCs in vivo showed that the three groups of mice had the greatest number of hUCMSCs in the nose at week 2. The mouse AR model was used to evaluate the efficacy of hUCMSC transplantation via multiple methods for AR. The distribution of hUCMSCs in vivo was tracked by detecting green fluorescent protein (GFP), and the treatment mechanism of hUCMSCs was elucidated. This study provides technical methods and a theoretical basis for the clinical application of hUCMSCs.
Retention of antibiotic activity against resistant bacteria harbouring aminoglycoside-N-acetyltransferase enzyme by adjuvants: a combination of in-silico and in-vitro study
Authors: Ahmed Shamim , Sony Sabrina Amita , Chowdhury Md. Belal , Ullah Md. Mahib , Paul Shatabdi , Hossain Tanvir 
Published: November 2020

AbstractInterference with antibiotic activity and its inactivation by bacterial modifying enzymes is a prevailing mode of bacterial resistance to antibiotics. Aminoglycoside antibiotics become inactivated by aminoglycoside-6′-N-acetyltransferase-Ib [AAC(6′)-Ib] of gram-negative bacteria which transfers an acetyl group from acetyl-CoA to the antibiotic. The aim of the study was to disrupt the enzymatic activity of AAC(6′)-Ib by adjuvants and restore aminoglycoside activity as a result. The binding affinities of several vitamins and chemical compounds with AAC(6′)-Ib ofEscherichia coli,Klebsiella pneumoniae, andShigella sonneiwere determined by molecular docking method to screen potential adjuvants. Adjuvants having higher binding affinity with target enzymes were further analyzed in-vitro to assess their impact on bacterial growth and bacterial modifying enzyme AAC(6′)-Ib activity. Four compounds—zinc pyrithione (ZnPT), vitamin D, vitamin E and vitamin K-exhibited higher binding affinity to AAC(6′)-Ib than the enzyme’s natural substrate acetyl-CoA. Combination of each of these adjuvants with three aminoglycoside antibiotics—amikacin, gentamicin and kanamycin—were found to significantly increase the antibacterial activity against the selected bacterial species as well as hampering the activity of AAC(6′)-Ib. The selection process of adjuvants and the use of those in combination with aminoglycoside antibiotics promises to be a novel area in overcoming bacterial resistance.
Initial mycophenolate dose in tacrolimus treated renal transplant recipients, a cohort study comparing leukopaenia, rejection and long-term graft function
Authors: Dave Vatsa , Polkinghorne Kevan R. , Leong Khai Gene , Kanellis John , Mulley William R. 
Published: November 2020

AbstractThe evidence supporting an initial mycophenolate mofetil (MMF) dose of 2 g daily in tacrolimus-treated renal transplant recipients is limited. In a non-contemporaneous single-centre cohort study we compared the incidence of leukopaenia, rejection and graft dysfunction in patients initiated on MMF 1.5 g and 2 g daily. Baseline characteristics and tacrolimus trough levels were similar by MMF group. MMF doses became equivalent between groups by 12-months post-transplant, driven by dose reductions in the 2 g group. Leukopaenia occurred in 42.4% of patients by 12-months post-transplant. MMF 2 g was associated with a 1.80-fold increased risk of leukopaenia compared to 1.5 g. Rejection occurred in 44.8% of patients by 12-months post-transplantation. MMF 2 g was associated with half the risk of rejection relative to MMF 1.5 g. Over the first 7-years post-transplantation there was no difference in renal function between groups. Additionally, the development of leukopaenia or rejection did not result in reduced renal function at 7-years post-transplant. Leukopaenia was not associated with an increased incidence of serious infections or rejection. This study demonstrates the initial MMF dose has implications for the incidence of leukopaenia and rejection. Since neither dose produced superior long-term graft function, clinical equipoise remains regarding the optimal initial mycophenolate dose in tacrolimus-treated renal transplant recipients.
A novel screening method for pediatric urinary tract infection using ordinary diapers
Authors: Ohnishi Takuma , Asada Nariaki , Furuichi Munehiro , Sekiguchi Shinichiro , Awazu Midori , Hori Naoaki , Kamimaki Isamu 
Published: November 2020

AbstractUrinary tract infection (UTI) is one of the most common bacterial infections in children. The symptoms of UTI in young children are nonspecific, therefore urine should be examined whenever UTI cannot be ruled out. In clinical settings, however, collecting urine from children who are not toilet trained is sometimes difficult, presenting a challenge in UTI management. Here, we developed a “diaper UTI test”, which enables the quick detection of pyuria in ordinary diapers, and investigated its sensitivity and specificity in a clinical study. The diaper UTI test is based on a leukocyte esterase reaction. Reagent was prepared in liquid form so that it can be absorbed by disposable diapers, where it will produce a violet color in the presence of pyuria. For the clinical study, we enrolled children younger than 3 years with potential UTI who underwent bladder catheterization for urine culture and urinalysis. Of the 65 children included, 21 were diagnosed with UTI. The sensitivity and specificity of the diaper UTI test were 90.5% (95% CI 69.6–98.8) and 93.2% (95% CI 81.3–98.6), respectively. Because of its convenience and good sensitivity, the diaper UTI test may be useful in the screening of pediatric UTI.
Pyramidal metamaterial absorber for mode damping in microwave resonant structures
Authors: Chikhi Nassim , Passarelli Andrea , Andreone Antonello , Masullo Maria Rosaria 
Published: November 2020

AbstractIn many resonant structures the damping of parasitic or higher order modes is indispensable to guarantee a correct and stable performance. This is particularly true in the microwave region in case of cavities or other resonant systems operating in accelerating structures, where the mitigation of spurious resonance effects is mandatory to achieve high quality particle beams. We present the results on the mode suppression in a real pillbox cavity by inserting a properly designed pyramidal metamaterial that acts as light, small volume damper for specific resonances in the range 3–4 GHz, only slightly perturbing other intrinsic modes. Measurements of the cavity response without and with the metamaterial absorber are presented and compared with full wave simulations. Field distribution for the pillbox intrinsic modes under scrutiny is also presented, showing that damping induced by the metamaterial critically depends on its relative position inside the cavity.
Design and characterisation of frequency selective conductive materials for electromagnetic fields control
Authors: Konoplev I. V. , Posthuma De Boer D. W. , Warsop C. M. , John M. 
Published: November 2020

AbstractTo prevent the electromagnetic (EM) wakefields excitation, protect detectors from damage at a range of installations and facilities including particle accelerators the EM field control is required. Conductive foils or wires providing EM protection and required thermal and mechanical properties are normally used. We suggest novel composite materials with uniquely designed frequency selective conductivity enabling them to overcome the properties of the conventional materials, protect from EM fields and supress undesirable phenomena. Theoretical and experimental investigations are carried out and the conductivity of designed and composite (dual-layer) aluminium/graphene metamaterials as well as graphene and aluminium foils is studied. The EM properties of these materials are compared, and conditions of full and partial electromagnetic transparency are discussed. Results observed allow engineering materials capable of EM field control, instability suppression including those observed in high-intensity particle accelerators and enabling control of an EM field generating media including relativistic charge particle beams.
From remote sensing and machine learning to the history of the Silk Road: large scale material identification on wall paintings
Authors: Kogou Sotiria , Shahtahmassebi Golnaz , Lucian Andrei , Liang Haida , Shui Biwen , Zhang Wenyuan , Su Bomin , van Schaik Sam 
Published: November 2020

AbstractAutomatic remote reflectance spectral imaging of large painted areas in high resolution, from distances of tens of meters, has made the imaging of entire architectural interior feasible. However, it has significantly increased the volume of data. Here we present a machine learning based method to automatically detect ‘hidden’ writings and map material variations. Clustering of reflectance spectra allowed materials at inaccessible heights to be properly identified by performing non-invasive analysis on regions in the same cluster at accessible heights using a range of complementary spectroscopic techniques. The world heritage site of the Mogao caves, along the ancient Silk Road, consists of 492 richly painted Buddhist cave temples dating from the fourth to fourteenth century. Cave 465 at the northern end of the site is unique in its Indo-Tibetan tantric Buddhist style, and like many other caves, the date of its construction is still under debate. This study demonstrates the powers of an interdisciplinary approach that combines material identification, palaeographic analysis of the revealed Sanskrit writings and archaeological evidence for the dating of the cave temple paintings, narrowing it down to the late twelfth century to thirteenth century.
Comparative proteomic analysis of serum from nonhuman primates administered BIO 300: a promising radiation countermeasure
Authors: Girgis Michael , Li Yaoxiang , Ma Junfeng , Sanda Miloslav , Wise Stephen Y. , Fatanmi Oluseyi O. , Kaytor Michael D. , Cheema Amrita K. , Singh Vijay K. 
Published: November 2020

AbstractHematopoietic acute radiation syndrome (H-ARS) and delayed effects of acute radiation exposure (DEARE) are detrimental health effects that occur after exposure to high doses of ionizing radiation. BIO 300, a synthetic genistein nanosuspension, was previously proven safe and effective against H-ARS when administered (via the oral (po) or intramuscular (im) route) prior to exposure to lethal doses of total-body radiation. In this study, we evaluated the proteomic changes in serum of nonhuman primates (NHP) after administering BIO 300 by different routes (po and im). We utilized nanoflow-ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (NanoUPLC-MS/MS) methods for comprehensive global profiling and quantification of serum proteins. The results corroborate previous findings that suggest a very similar metabolic profile following both routes of drug administration. Furthermore, we observed minor alterations in protein levels, 2 hours after drug administration, which relates to the Cmax of BIO 300 for both routes of administration. Taken together, this assessment may provide an insight into the mechanism of radioprotection of BIO 300 and a reasonable illustration of the pharmacodynamics of this radiation countermeasure.