bluuebunny/crossref_metadata_2025_split huggingface dataset:
Some interesting features of the rich chemistry around electron-deficient systems
Authors: Mó Otilia 
Published: October 2019

AbstractIn this short review, different phenomena that are triggered by the interaction of different compounds or clusters of compounds with electron-deficient systems, in particular beryllium and boron compounds, have been discussed in some detail. Particular attention was devoted to the huge acidity enhancements that can be induced through the interaction of conventional bases with B or Be containing compounds, which change these conventional bases in extremely strong proton donors. We have paid also attention to the cooperativity between Be bonds with other weak interactions, which results in a substantial increase of their strength, that can lead in some specific cases to the spontaneous formation of ion-pairs in the gas phase. Finally, the behavior of different Be derivatives as electron and anion sponges is discussed as well as the conditions needed to have clusters exhibiting rather strong Be–Be bonds, even though the Be–Be interaction in Be2dimer is extremely weak. Finally, some attention was paid to systems with extremely short Be–Be distances but without a bond.
Foreword for PAC special issue 4th International Conference on the Periodic Table (Mendeleev 150)
Authors: Zhou Qi-Feng 
Published: October 2019

Abstract
The conference Mendeleev 150 was held to join the worldwide celebrations of the 150th Anniversary of the publication of Dmitri I. Mendeleev’s Periodic Table of Chemical Elements and the International Year of the Periodic Table proclaimed by the United Nations. The presentations of the invited speakers were published by the Journal of Pure and Applied Chemistry as a special issue. The papers in this issue formed a broad picture of the Periodic Table: the history, the people, the reasoning, the mathematical description of the law, and the efforts to predict and to create any new elements. The highlights of the presentations are briefly introduced in this article as the Preface to the special issue.
William Barlow’s early publications in the ‘Zeitschrift für Krystallographie und Mineralogie’ and their influence on crystal structure research
Authors: Paufler Peter 
Published: October 2019

Abstract
The English crystallographer William Barlow is famous for two achievements, both published in German, in Zeitschrift für Krystallographie und Mineralogie between 1894 and 1901. They concern the derivation of all possible symmetrical arrangements of points in space and the idea to represent crystal structures by replacing points by spheres. His results had an impact upon crystal structure modelling and describing crystal morphology. Utilizing self-made models, he found the 230 space group types of symmetry obtained earlier by both E. S. Fedorow and A. Schoenflies in a different manner. The structures he proposed before the discovery of X-ray diffraction served in some cases as starting point for the interpretation of diffraction patterns thereafter.
Cerrahi süreçteki sağlık profesyonellerinin kişilerarası iletişim tarzları ve ekip çalışması tutumları
Authors: SALDAMLI Aslı , IŞIK ANDSOY İşıl 
Published: October 2019

Amaç: Araştırmanın amacı, cerrahi girişim sürecinde yer alan sağlık profesyonellerinin kişilerarası ilişki tarzları ve ekip çalışmasına yönelik tutumlarının değerlendirilmesidir.Gereç ve Yöntem: Araştırma tanımlayıcı tiptedir. Örnekleme gönüllü 126 cerrahi ekip üyesi alındı. Veriler “Kişisel Bilgi Formu”, “Kişilerarası İletişim Tarzları Ölçeği (KİTÖ)” ve “Ekip Çalışması Tutumları Ölçeği (EÇTÖ)” ile toplandı. Bulgular: Çalışmada EÇTÖ’den en düşük puanı hemşirelerin, EÇTÖ ve KİTÖ’den en yüksek puanı ise diğer sağlık profesyonellerinin aldığı saptandı. Yine EÇTÖ’nün iletişim alt boyutundan en düşük puanı alan hekimlerdi. Diğer sağlık profesyonellerinin, KİTÖ’nün kaçıngan tarz alt boyutundan aldıkları puan ortalamasının hemşirelere göre anlamlı derecede yüksek, EÇTÖ’nün iletişim alt boyutundan aldıkları puan ortalamalarının hemşire ve hekimlere göre anlamlı derecede yüksek olduğu belirlendi. Çalışmada 21 yıl ve üzeri çalışan cerrahi ekip üyelerinin KİTÖ’nün baskın tarz alt boyutundan aldıkları puan ortalamasının daha az süre çalışan ekip üyelerine göre anlamlı derecede yüksek olduğu bulundu. Sonuç: Bu doğrultuda cerrahi ekip üyelerine yönelik kişilerarası iletişim becerilerini ve ekip çalışması tutumlarını geliştirmeye yönelik eğitimlerin planlanması, var olan sorunların saptanması, giderilmesine yönelik bireysel ve kurumsal girişimlerin yapılması önerilmektedir.
Suturae cranii’nin morfolojik ve morfometrik değerlendirilmesi
Authors: KILIÇ ŞAFAK Nazire 
Published: October 2019

Amaç: Bu çalışmanın amacı, sutura coronalis, sutura sagittalis ve sutura lambdoidea sutural açıklığı morfolojisinin ve morfometrisinin değerlendirilmesidir. Gereç ve Yöntem: Bu amaç ile, cinsiyeti ve yaşı belli olmayan Anadolu populasyonuna ait 17 adet cranium sutural açıklık derecesine göre (Derece 0, 1, 2, 3, 4) analiz edilmiştir ve daha sonra sutura cranii uzunlukları elektronik kumpas ile ölçülmüştür. Bulgular: Çalışmamızda sutura coronalis Derece 0 %0, Derece 1 %67.85, Derece 2 %3.57, Derece 3 ve 4 ise %14.28 ; sutura sagittalis Derece 0 %0, Derece 1 %53.57, Derece 2 ve 3 %14.28, Derece 4 %17.85, sutura lambdoidea Derece 0 %0, Derece 1 %60.71, Derece 2 %14.28, Derece 3 %0, Derece 4 %7.14 olarak gözlenmiştir. Sutura coronalis, sutura sagittalis ve sutura lambdoidea uzunlukları ise sırası ile 116.80±7.70 mm, 106.59±7.18 mm, 109.05±6.76 mm olarak bulunmuştur. Sonuç: Çalışma sonuçlarımızın özellikle anatomi, antropoloji ve osteopatik manipulatif tıp ile ilgili literatüre katkıda bulunacaktır.
El falanks kırıklarında açık redüksiyon ve plak ile fiksasyonun sonuçları
Authors: ÖZCAN Çağrı 
Published: October 2019

Amaç: Multifragmanter, kısalık oluşan ve takiplerinde redüksiyon kaybı görülen falanks kırıklarının açık redüksiyon, mini plak ile fiksasyonunun radyolojik ve fonksiyonel sonuçlarını degerlendirmektir.Gereç ve Yöntem: 2008–2016 Yılları arasında hastanemizde 28 tane falanks kırığı sebebiyle mini plak ile fiksasyon yapılan hastalar retrospektif olarak incelenmiştir. 28 hastanın 30 falanksı çalışmaya dahil edilmiştir. Hastalar son kontrollerine geldiğinde Quick Dash skorları, kavrama kuvvetlerine, fonksiyonel eklem hareket açıklığına bakılmıştır. Hastaların kaynama süresi, yatış süresileri, cerrahi süre ve komplikasyonlar değerlendirilmiştir.Bulgular: Hastaların ortalama yaşları 37.3(23–57) ortalama takip süresi 23 (7–84) aydır. Hastaların son kontrollerindeki Quick Dash skorları ortalama 8,43(0-27,5) olarak değerlendirilmiştir. Kavrama kuvveti kırık elde 43 (25-60) kgW, sağlıklı elde 47 (35-60) kgW olarak ölçüldü. Hastaların 3 ekleminin (MP, PİP, DİP) toplam hareket açıklığı 240°(170 –270) olarak ölçülmüştür. Hastaların ortalama kaynama süresi 34.9 gün (25-50) dür. Hastaların yatış süresi ortalama 1.45 Gün (1-3) dür. Cerrahi süresi ortalama 60.25 dk (45-90) dır. Klinik olarak 28 hastanın 6 tanesinde eklem sertliği 1 tanesinde rotasyon tespit edilmiştir. 6 hasta yapılan cerrahiden memnun olmadığı görülmüştür.18 hasta parmaklarında şişlik kalmasından şikayetçiydi. Sonuç: Falanks kırıklarında açık redüksiyon ve internal fiksasyon yapmanın avantajı rigit bir tespit erken dönemde iş gücü kaybının azalmasıdır. Hastalara cerrahi sonrası erken dönemde hareket başlanması hareket kısıtlılığı açısından önemlidir. Multifragmanter, deplase ve kısalık oluşan falanks kırıklarında cerrahi erken dönemde hareket verme avantajı sağlar. Rotasyon ve eklem sertliği cerrahi sonrası karşılaşabilecek sorunların başında gelmektedir.
Morphometric measurements of the internal acoustic meatus
Authors: ÖZANDAÇ POLAT Sema , UYGUR Ayşe Gül , ÖKSÜZLER Fatma Yasemin , ÖKSÜZLER Mahmut , YÜCEL Ahmet Hilmi 
Published: October 2019

Purpose: This study was aimed to determine the morphometry of internal acoustic meatus in healthy Turkish population aged between 18-60 years.Materials and Methods: This study which was a retrospective study, was carried out from the 142 healthy adult subjects (59 females; 83 males) aged 18-60 years. Subjects had undergone routine test in the Radiology Department. Results: The groups were divided into four groups according to age. The overall means of the measurements were: the internal acoustic meatus length 9.71 mm (R) and 9.92 mm (L); the internal acoustic meatus width 3.97 mm (R) and 3.95 mm (L); the internal acoustic meatus height 4.65 mm (R) and 4.66 mm (L) in females, respectively. The same dimensions were found 9.61 mm (R) and 9.87 mm (L); 4.18 mm (R) and 4.15 mm (L); 5.13 ±0.85 mm (R) and 5.13±0.90 mm (L) in males, respectively. Also, the ratio of IAM’width to height was calculated 0.860±0.125 and 0.825±0.137 in females and males in right side, respectively whereas in left side the corresponding value was 0.855±0.125 and 0.820±0.142 in females and males, respectively.Conclusion: Knowledge of the normal dimensions of the internal acoustic meatus is more important for determination of the clinical and tumor processes.
Relationship between the psychosocial impact of malocclusion and objective orthodontic treatment need
Authors: HALİLOĞLU ÖZKAN Tuğba , YAZICIOĞLU Sabahat 
Published: October 2019

Purpose: The purpose of this study was to evaluate the association between the psychosocial effect of malocclusion and objective orthodontic treatment need in Turkish adolescents and young adults.Materials and Methods: The study sample consisted of 152 adolescents (mean age; 14.91), and 48 young adults (mean age; 21.83). Participants were asked to answer the “Psychosocial Impact of Dental Aesthetics Questionnaire (PIDAQ)”. Objective treatment need was evaluated by an experienced clinician, using the Aesthetic Component (AC) of the Index of Orthodontic Treatment need. (IOTN). Results: Statistical analyzes revealed no significant difference between adolescents and young adults either in PIDAQ and AC scores. There was also no significant gender differences in PIDAQ and AC scores either in adolescents and young adults. A positive correlation was found between the PIDAQ score and the AC value just in adolescent females (r= 0.263, p=0.012).Conclusion: Malocclusion has similar degree of psychosocial impacts in adolescents and young adults. Female adolescents appear more aware of their dental appearance and feel higher psychosocial impacts than adolescent males.
Psychometric properties of the Oral Health Assessment Tool Turkish Version
Authors: ERCAN ŞAHİN Nilay , JABLONSKİ Rita Anne 
Published: October 2019

Purpose: The aims of this study were to conduct validity and reliability assessments of Turkish version of Oral Health Assessment Tool. Materials and Method: The Oral Health Assessment Tool underwent forward and backward Turkish translations and content validity assessments. After modifications, the final instrument was used to assess the oral health of 100 Turkish nursing home residents. Inter-rater reliability and internal consistency assessments were obtained based on its use in this sample. Discriminant validity analyses were conducted using item average points for the top and bottom groups.Results: Content validity indices from 6 experts exceeded 0.80. Discriminative validity, using the top and bottom averaged scores, was supported for all of the categories save dental pain. Inter-rater reliability for the individual categories ranged from 0.54-1.00 (Kappa statistic) and was 0.72 (Spearman’s Correlation Coefficient) for the overall instrument. Conclusion: The Turkish version of Oral Health Assessment Tool was found to be both valid and reliable for cognitively intact nursing home residents. Additional testing with cognitively-impaired nursing home residents is warranted.
Effect of vitamin D deficiency on osteoarthritis and bone mineral density in elderly patients
Authors: ÖZLER Kenan 
Published: October 2019

Purpose: We aimed to determine the effect of inadequate vitamin D level on osteoartritis (OA) and bone mineral density (BMD) in female and male elderly patients with early and late stage OA with different BMD, and also the relationship between vitamin D and knee function scores in female and male OA patients.Materials and Methods: One hundred and fortytwo female and one hundred thirty-five male knee OA patients were enrolled in the study. The knee OA was classified as early and late stage. WOMAC score, KOOS score, BMD and Vitamin D levels were measured. Results: Vitamin D levels patients were statistically significantly lower in female OA than male OA group. Calcium and phosphorus levels were significantly higher in female OA patients than male OA group. There was no difference between vitamin D, vitamin B12, calcium, phosphorus, WOMAC score and KOOS scores in early and late stage OA patients with osteoporosis, osteopenia and normal BMD. WOMAC score was significantly higher in male patients with osteoporosis early stage and late stage OA than patients with osteopenia and normal BMD. The age odds ratio (OR) was 1,047 (95% CI = 1,009-1,086) in female OA patients, and OR was 1.090 (95% CI = 1,021-1,163) in male OA patients.Conclusion: Vitamin D supplementation may be said increase BMD, slow down the progression of osteoporosis, reduce pain, but have no effect on OA progression and knee function scores.
Yoğun bakım ünitesinde bakteriyemi tanısı ile takip edilen hastaların değerlendirilmesi
Authors: AKYILDIZ Özay , BEŞLİ Yeşim , KOCAGÖZ Ayşe Sesin 
Published: October 2019

Amaç: Bu çalışmada, hastanemiz Genel Yoğun Bakım Ünitesi'nde (GYBÜ) yatan hastaların kan kültürlerinden izole edilen mikroorganizmalar ve antibiyotiklere duyarlılıkları retrospektif olarak değerlendirilerek uygun ampirik tedavi seçimine yol gösterici verilerin elde edilmesi amaçlanmıştır.Gereç ve Yöntem: Hastanemizde yatan 18 yaş ve üzeri 152 hastanın kan kültürlerinden izole edilen 163 mikroorganizma ve antibiyotiklere duyarlılık sonuçları retrospektif olarak değerlendirildi. Klinikte yatan hastaların ateşli dönemlerinde alınan kan kültürleri BACTEC otomatize kan kültür sisteminde inkübe edildi. Bulgular: Üreyen mikroorganizmaların %68'ini (n=111) Gram pozitif bakteriler, %25'ini (n=40) Gram negatif bakteriler ve %7'sini (n=12) ise mantarlar oluşturmuştur. En sık izole edilen mikroorganizmalar sırasıyla koagülaz negatif stafilokoklar (KNS), Escherichia coli ve Candida spp.‘dir. Kan kültürlerinden izole edilen Gram negatif etkenlerin %7'si (n=12) E.coli, %6'sı (n=9) Klebsiella spp., %5'i (n=8) Pseudomonas spp., %4'ü (n=6) Acinetobacter spp. olarak belirlendi. Genişlemiş Spektrumlu Beta Laktamaz (GSBL) pozitifliği, E. coli izolatlarında %75 (n=9), Klebsiella spp. izolatlarında ise %78 (n=6) olarak saptandı.Sonuç: İzole edilen enfeksiyon etkenlerinin türü, sıklığı ve antibiyotik direnç durumları hakkında bilgi sahibi olup her merkezin kendi antibiyotik kullanım politikasını bu bilgiler ışığında belirlemesi morbidite ve mortalite oranlarını azaltmaya katkı sağlayacaktır.
Molecular modeling of the interaction of the dihydroquercetin and its metabolites with cyclooxygenase-2
Authors: Terekhov R. P. , Selivanova I. A. 
Published: October 2019

Background.Dihydroquercetin (DHQ) is a natural flavonoid. It has a wide range of pharmacological effects, which includes anti-inflammatory activity. There is a gap in our knowledge about the biochemical mechanisms of the therapeutic potency implementation of this compound. This fact slows down the process of the drug development using DHQ. Molecular modeling is designed to further translate the research from the fundamental experimentation to the real clinical practice. Purpose. The study objective was to estimate DHQ as a cyclooxygenase-2 (COX-2) inhibitor by using in silico analysis.Materials and methods. The information about the COX-2 structure was obtained from the Protein Data Bank (code 5KIR). The 3D-models of DHQ were generated by using the ChemBioDraw Ultra software. Docking was carried out in the GOLD program after the corresponding validation of molecular modeling algorithms based on experimental data of X-ray diffraction analysis.Results. The design of this study is based on the rational selecting of the virtual ligand structures. It gives an opportunity to optimize the quantum-mechanical calculation. By using in silico analysis, it was shown that DHQ and some of its metabolites demonstrate ability of binding to SER353, SER530, and ARG513 of COX-2 at the catalytic site.Conclusion. Important α-amino acids for intermolecular interaction of DHQ and its metabolites with COX-2 were determined during this study. Our data can be used for the development of new antiinflammatory drugs on the base of DHQ.
Alternative scaffolds in radionuclide diagnosis of malignancies
Authors: Bragina O. D. , Chernov V. I. , Zeltchan R. V. , Sinilkin I. G. , Medvedeva A. A. , Larkina M. S. 
Published: October 2019

This review discusses a relatively new class of targeted molecules that is being actively studied for radionuclide diagnosis and treatment of malignancies. The full-size antibodies used so far have non-optimal pharmacological properties, slow distribution in the body, poor penetration into the tissue and kidney excretion, and high immunogenicity, which significantly complicates their use in clinical practice. Over the past decade, a new class of targeted molecules, called “non-immunoglobulin scaffolds” have become popular; they have all the requirements for optimal delivery of a radionuclide to tumor cells. Scaffolds usually are smaller in size in comparison with antibodies, but they are larger than peptides, and are characterized by high affinity and optimal biochemical, biophysical, biological, and economic features. The advantages of such proteins are their stable structure, good penetration into tissues, the possibility of additional functionalization and expression in the bacterial system, which ensures low production costs.The results of preclinical and clinical studies for diagnosis of malignancies using such proteins as affibody, adnectin, DARPins, etc., have demonstrated their high specificity, affinity, good tolerance and low immunogenicity.
The role of linoleic acid in oxidative damage of hemoglobin due to cytomegelavirus infection during pregnancy
Authors: Andrievskaya I. A. , Ishutina N. A. 
Published: October 2019

The goalis to study the mechanisms of linoleic acid-dependent oxidative damage to hemoglobin in blood erythrocytes of pregnant women with cytomegalovirus (CMV) infection during the first trimester.Materials and methods. The study included 55 CMV-seropositive pregnant women at 8–11 weeks pregnant, aged 24,7 ± 0,18 years. 20 women had exacerbated cytomegalovirus infection and in 35 women a latent course of the disease was observed. The control group consisted of 20 CMV-seronegative pregnant women, comparable in age and gestational age with the group of pregnant women with cytomegalovirus infection. The levels of linoleic acid, superoxide dismutase, glutathione peroxidase and methemoglobin in the blood were studied by the spectrophotometry. Glutathione was determined by histochemical methods, the total amount of hemoglobin was measured using the automatic hematological analyzer, and hydrogen peroxide level was calculated by enzyme immunoassay.Results. In cytomegalovirus infection, an increase in the indices of exogenous hydrogen peroxide and linoleic acid in blood erythrocytes of pregnant women is observed. During the period of acute disease in the first trimester of pregnancy it causes oxidative modification and a decrease in the level of not only superoxide dismutase, glutathione peroxidase and glutathione, the processes involved in the redox regulation of thiol-disulfide exchange of erythrocytes, but also hemoglobin with formation of large amount of methemoglobin, which contributes to reduction of oxygen metabolism and development of hemic hypoxia. In the latent course of the disease, the oxidative damage to hemoglobin in the erythrocytes of pregnant women is mitigated by the increase in the activity of redox enzymes, which maintains oxygen homeostasis at the level necessary for the development of pregnancy.
Open and endovascular surgery for stenosis of the peripheral regions of arteriovenous fistula
Authors: Kardanakhishvili Z. B. , Zulkarnaev A. B. 
Published: October 2019

Vascular access is the cornerstone of hemodialysis. With vascular access dysfunction, the results of treatment of patients with stage 5 chronic kidney disease significantly deteriorate. One of the most common causes of vascular access failure is peripheral venous stenosis. Despite the variety of initiating factors, the morphological substrate of stenotic damage to the arteriovenous fistula (or arteriovenous anastomosis) in most cases is neointimal hyperplasia. Stenotic lesions of the arterivenous fistula are strongly associated with an increased risk of thrombosis and loss of vascular access. There are 4 typical localizations of stenosis: arteriovenous or arteriograft anastomosis, stenosis of the juxta-anastomotic segment of the fistula, stenosis of the functional segment of the fistula, and stenosis of the cephalic arc.The most common indication for surgical treatment is vascular access failure; less common indications are clinical symptoms of venous insufficiency.There are various methods of open reconstruction of the stenotic segment of the fistula vein: resection, prosthetics with a synthetic vascular graft, prosthetics or plastic repair of the autologous vein wall, complete or partial drainage of the prestenotic segment of the vein, etc. Currently an alternative method of stenosis repair using endovascular interventions is gaining popularity. In contrast to central vein stenosis, where endovascular interventions are the gold standard, in peripheral vein stenosis it is only an adjuvant method. Complications of endovascular interventions are extremely rare.Despite the fact that endovascular interventions have almost absolute probability of technical success, the primary patency is not high and is about 50% in six months. The use of bare stents is not accompanied by an increase in primary patency. The use of stent-grafts can increase the primary patency, especially in the plastic repair of challenging stenoses of the graft-vein anastomosis or cephalic arch.Many issues related to endovascular interventions remain unresolved, which requires further research.
Helminths and intestinal microbiota interaction: role in the development of noncommunicable diseases
Authors: Sokolova T. S. , Fedorova O. S. , Saltykova I. V. , Petrov V. A. , Fedotova M. M. , Kovshirina Yu. V. , Deev I. A. , Ogorodova L. M. 
Published: October 2019

There is an increase in the prevalence of chronic, noncommunicable diseases, including allergic and autoimmune diseases in developed countries. In this regard, the study of factors modifying the population’s immune response is very important.According to the “old friends” hypothesis , insufficiency of infectious stimulation and decrease in prevalence of helminthiasis are associated with development of noncommunicable diseases. Studies revealed that intestinal parasites modulate the host immune response and alter susceptibility to immunological diseases. It is suggested that one of the pathogenetic mechanisms of immune response modulation by parasites is an increase in the content of gastrointestinal bacteria with anti-inflammatory effect. Advanced technologies of microorganism identification provide a deep insight into the microbiota in different pathologies. The study of changes in the intestine and bile microbiota of the host in helminthiases provides new possibilities for prevention, diagnosis and control of such conditions as chronic inflammatory bowel diseases and allergic diseases. The purpose of this review is to analyze current experimental and clinical data on intestinal microbiota in helminth infections and possible association with development of chronic noncommunicable diseases.