bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of sandblasting on the surface roughness and residual stress of 3Y-TZP (zirconia)
Authors: Finger Christin , Stiesch Meike , Eisenburger Michael , Breidenstein Bernd , Busemann Sarah , Greuling Andreas 
Published: September 2020

AbstractA defined surface roughness is important for the adhesive bonding of veneering ceramic to zirconia frameworks. Thus, we investigated the effects that sandblasting has upon the surface roughness and residual stress of zirconia. So as to achieve well-defined blasting parameters and also generate highly reproducible results; a custom-made, automated sandblasting machine was constructed (based on a 3D-printer construction kit). Thirty-two samples (measuring 30 mm × 35 mm × 0.2 mm) were cut from densely sintered 3Y-TZP blanks and then ground with a 45 µm grinding disc. After undergoing regeneration firing, the samples were sandblasted with varying working parameters: blasting angle (45°, 60° and 90°); blasting pressure (2 bar, 4 bar and 6 bar); and working distance (0.5 cm, 1.0 cm and 1.5 cm). The sandblasting path was chosen so as to create samples with an even surface roughness. Changes in blasting pressure resulted in the greatest changes in the surface roughness, the highest surface roughness values were achieved with sandblastings perpendicular to the sample surface. Furthermore, a correlation was found between the mean surface roughness and the residual stress.
Application of classification neural networks for identification of damage stages of degraded low alloy steel based on acoustic emission data analysis
Authors: Krajewska-Śpiewak Joanna , Lasota Igor , Kozub Barbara 
Published: September 2020

AbstractThe paper presents the influence of low alloy steel degradation on the acoustic emission (AE) generated during static tension of notched specimen. The material was cut from a technological pipeline long-term operated in the oil refinery industry. Comparative analysis of AE activity generated by damage process of degraded and new material has been carried out. The different AE parameters were used to detect different stages of fracture process of low alloy steel under quasi-static tensile test. Neural networks with three layers were created with Broyden–Fletcher–Goldfarb–Shanno learning algorithm for a database analysis. The different AE parameters were included in the input layer. Classification neural networks were created in order to determine the stages of material degradation. The results obtained from the carried out studies will be used as the basis for new methodology development of the assessment of the structural condition of in-service equipment.
Comparative analysis of anxiety and depression prevalence between individuals with and without inflammatory bowel disease
Authors: Santos Carlos Henrique Marques dos , Galindo Amanda Cristine Alcântara , Silva Bárbara Alencar da , Dantas Camila Rodrigues , Guilherme Isadora Albuquerque de Araújo , Gomes José Elias Basmage Nunes , Dallacqua Kayque Michel , Souza Mariana Pereira de , Senna Patricia Szlachta 
Published: September 2020

Abstract
Rationale Inflammatory bowel diseases − Crohn's Disease (CD) and Ulcerative Colitis (UC) − are chronic disorders associated, for several reasons, with psychological symptoms and stigmatization of patients.
Aim To compare individuals with and without inflammatory bowel diseases in relation to the prevalence of anxiety and depression.
Method The psychological aspect was analyzed using two globally validated questionnaires − the Patient Health Questionnaire (PHQ-9) and the General Anxiety Disorder questionnaire (GAD-7) − in addition to a sociodemographic questionnaire. Data collection was carried out in three groups, each one consisting of 100 individuals; the first comprising outpatients with a diagnosis of inflammatory bowel diseases, the second comprising outpatients without a diagnosis of inflammatory bowel diseases and the third by non-outpatients without a diagnosis of inflammatory bowel diseases.
Results The groups were similar regarding gender, ethnicity, marital status and tobacco use. As for social class, the IBD group showed a predominance of class E (46%), the outpatient group a predominance of class D (44%) and the non-outpatient group, class C (44%) (p < 0.001). The non-outpatient group also had a higher number of young individuals (mean = 36.69 years) (p < 0.001). There was a higher number of individuals with depression and anxiety in the IBD and outpatient control groups when compared to the non-outpatients’ group (p < 0.001), but with no difference between the two first groups. There was a higher number of individuals with severe degree anxiety in the IBD group (36%) compared to the non-outpatients’ group (8%) (p < 0.001).
Conclusion Greater severity and a prevalence of anxiety and depression were observed in the group with inflammatory bowel diseases.
Informal learning of popular music: gender monoglossia and heteroglossia
Authors: Butler Alison , Bylica Kelly , Wright Ruth 
Published: September 2020

AbstractThis paper reports on a small-scale study in an elementary school in Southern Ontario, Canada. The study investigated relationships between students’ perceptions and practices of gender in popular music education with particular attention given to communication, instruments and technology and development of freedoms and constraints. The findings present a more opaque picture than previous research, suggesting that students frequently transgress binary gendered patterns of practice and perception in this particular field. Gender monoglossia and heteroglossia provide a useful explanatory framework for analysis, indicating that further application of these concepts to issues in popular music education might be most fruitful.
A multiple levels of analysis examination of the performance goal model of depression vulnerability in preadolescent children
Authors: Bendezú Jason José , Wodzinski Alaina , Loughlin-Presnal John E. , Mozeko Jesse , Cobler Sierra , Wadsworth Martha E. 
Published: September 2020

AbstractIf performance goals (i.e., motivation to prove ability) increase children's vulnerability to depression (Dykman, 1998), why are they overlooked in the psychopathology literature? Evidence has relied on self-report or observational methods and has yet to articulate how this vulnerability unfolds across levels of analysis implicated in stress–depression linkages; for example, hypothalamic–pituitaryadrenal axis (HPA), sympathetic nervous system (SNS). Utilizing a multiple-levels-of-analysis approach (Cicchetti, 2010), this experimental study tested Dykman's goal orientation model of depression vulnerability in a community sample of preadolescents (N = 121, Mage = 10.60 years, Range = 9.08–12.00 years, 51.6% male). Self-reports of performance goals, attachment security, and subjective experience of internalizing difficulties were obtained in addition to objective behavioral (i.e., task persistence) and physiologic arousal (i.e., salivary cortisol, skin conductance level) responses to the Trier Social Stress Test (TSST) and two randomly assigned coping conditions: avoidance, distraction. Children with performance goals reported greater internalizing difficulties and exhibited more dysregulated TSST physiologic responses (i.e., HPA hyperreactivity, SNS protracted recovery), yet unexpectedly displayed greater TSST task persistence and more efficient physiologic recovery during avoidance relative to distraction. These associations were stronger and nonsignificant in the context of insecure and secure attachment, respectively. Findings illustrate a complex matrix of in-the-moment, integrative psychobiological relationships linking performance goals to depression vulnerability.
Ultrastructure of the Bacteriocytes in the Midgut of the Carpenter ant Camponotus rufipes: Endosymbiont Control by Autophagy
Authors: Gonçalves Wagner G. , Fernandes Kenner M. , Silva Ana Paula A. , Gonçalves Danilo G. , Fiaz Muhammad , Serrão José Eduardo 
Published: September 2020

AbstractThe carpenter ant Camponotus rufipes has intracellular bacteria in bacteriocytes scattered in the midgut epithelium, which have different amounts of endosymbionts, according to the developmental stages. However, there are no detailed data about the midgut cells in adult workers. The present work aimed to evaluate the morphology and cellular events that coordinate the abundance of endosymbionts in the midgut cells in C. rufipes workers. The midgut epithelium has digestive cells, bacteriocytes, and cells with intermediate morphology. The latter is similar to bacteriocytes, due to the abundance of endosymbionts, and similar to digestive cells, due to their microvilli. The digestive and intermediate cells are rich in autophagosomes and autolysosomes, both with bacteria debris in the lumen. These findings suggest that midgut cells of C. rufipes control the endosymbiont level by the autophagy pathway.
A randomized clinical trial assessing a pragmatic intervention to improve supportive care for family caregivers of patients with lung cancer
Authors: Aubin Michèle , Vézina Lucie , Verreault René , Simard Sébastien , Desbiens Jean-François , Tremblay Lise , Dumont Serge , Dogba Maman Joyce , Gagnon Pierre 
Published: September 2020

AbstractObjectiveFamily caregivers (FCs) of cancer patients often experience high distress. This randomized clinical trial assessed the feasibility and preliminary effects of an intervention to improve FC supportive care.MethodA pragmatic and minimal intervention to improve FC supportive care was developed and pretested with FCs, oncology team, and family physicians to assess its relevance and acceptability. Then, FCs of lung cancer patients were randomized to the intervention or the control group. The intervention included (1) systematic FC distress screening and problem assessment in the first months after their relative cancer diagnosis, and every 2 months after; (2) privileged contact with an oncology nurse to address FC problems, provide emotional support and skills to play their caregiving role; (3) liaison with the family physician of FCs reporting high distress (distress thermometer score ≥4/10) to involve them in the provision of supportive care. Distress, the primary outcome, was measured every 3 months, for 9 months. Secondary outcomes included quality of life, caregiving preparedness, and perceived burden. At the end of their participation, a purposive sample of FC from the experimental group was individually interviewed to assess the intervention usefulness. Content analysis was performed.ResultsA total of 109 FCs participated in the trial. FC distress decreased over time, but this reduction was observed in both groups. Similar results were found for secondary outcomes. However, FCs who received the intervention felt better prepared in caregiving than controls (p= 0.05). All 10 interviewed FCs valued the intervention, even though they clearly underused it. Knowing they could contact the oncology nurse served as a security net.Significance of resultsAlthough the intervention was not found effective, some of its aspects were positively perceived by FCs. As many of them experience high distress, an improved intervention should be developed to better support them.
A compact double-band planar printed slot antenna for sub-6 GHz 5G wireless applications
Authors: Ishteyaq Insha , Shah Masoodi Issmat , Muzaffar Khalid 
Published: September 2020

AbstractA planar rectangular slot antenna with dual-band operation and realized higher peak gain is proposed, designed, and fabricated for sub-6 GHz 5G applications. The antenna possesses a rectangular radiating slot with the inverted stub on its upper edge excited simultaneously by a micro-strip feed line having a double folded T-shaped structure. The fabricated design is of compact size with the radiating portion of 0.3 λ0 × 0.17 λ0 (λ0 represents free-space wavelength) and profile of 0.009 λ0. The measured results show the operating frequency bands of 3.29–3.63 GHz and 4.3–5.2 GHz, with a peak gain of around 7.17 dBi. The higher frequency band is generated by the feed patch and the slot whereas lower resonant frequency band is generated by the stub loaded on the slot. The measured results are in a good agreement with the simulated results. The proposed design is suitable for the International Telecommunications Union sub 6 GHz applications.
On the Money: Parental Perspectives About Finances and Type 1 Diabetes in Youth
Authors: Eshtehardi Sahar S. , Anderson Barbara J. , Cao Viena T. , McKinney Brett M. , Thompson Deborah I. , Marrero David G. , Hilliard Marisa E. 
Published: September 2020

Objective: Given the costs of diabetes care, finances may be a source of stress for parents of youth with type 1 diabetes. The purpose of this study was to characterize the perspectives of parents of youth with type 1 diabetes about diabetes-related expenses and any potential relationship with quality of life. Methods: Parents ( n = 23, 96% mothers) of youth with type 1 diabetes (aged 5–17 years; 35% female, mean HbA1c = 8.7%) each completed a semistructured qualitative interview. Verbatim transcripts were coded using thematic analysis to derive central themes related to diabetes-related finances. Results: Two primary themes emerged: (a) sacrifices and hardships—Parents described making decisions about household finances to accommodate diabetes-related expenses and employment choices based on salary and benefits; many described prioritizing spending for diabetes supplies, healthy foods, and medical bills and forgoing spending related to family vacations, recreation, and personal needs; and (b) gratitude—Parents discussed feeling thankful for employment and insurance coverage, which help reduce diabetes-related financial stressors or hardships. Conclusions: Care of families of youth with type 1 diabetes should consider parents’ financial experiences and effects on family. Routinely asking about diabetes-specific financial issues in relation to family stress and coping may help inform behavioral and medical care and can facilitate referrals to social work. Implications for Impact Statement Type 1 diabetes care is expensive, and finances can be a significant source of distress for families. Consideration of how parents may need to make sacrifices to afford diabetes expenses and their gratitude for the resources they are able to access can inform pediatric psychologists’ care of families living with type 1 diabetes.
Chitinase-3 like-protein-1 function and its role in diseases
Authors: Zhao Ting , Su Zhongping , Li Yingchang , Zhang Xiaoren , You Qiang 
Published: September 2020

AbstractNon-enzymatic chitinase-3 like-protein-1 (CHI3L1) belongs to glycoside hydrolase family 18. It binds to chitin, heparin, and hyaluronic acid, and is regulated by extracellular matrix changes, cytokines, growth factors, drugs, and stress. CHI3L1 is synthesized and secreted by a multitude of cells including macrophages, neutrophils, synoviocytes, chondrocytes, fibroblast-like cells, smooth muscle cells, and tumor cells. It plays a major role in tissue injury, inflammation, tissue repair, and remodeling responses. CHI3L1 has been strongly associated with diseases including asthma, arthritis, sepsis, diabetes, liver fibrosis, and coronary artery disease. Moreover, following its initial identification in the culture supernatant of the MG63 osteosarcoma cell line, CHI3L1 has been shown to be overexpressed in a wealth of both human cancers and animal tumor models. To date, interleukin-13 receptor subunit alpha-2, transmembrane protein 219, galectin-3, chemo-attractant receptor-homologous 2, and CD44 have been identified as CHI3L1 receptors. CHI3L1 signaling plays a critical role in cancer cell growth, proliferation, invasion, metastasis, angiogenesis, activation of tumor-associated macrophages, and Th2 polarization of CD4+T cells. Interestingly, CHI3L1-based targeted therapy has been increasingly applied to the treatment of tumors including glioma and colon cancer as well as rheumatoid arthritis. This review summarizes the potential roles and mechanisms of CHI3L1 in oncogenesis and disease pathogenesis, then posits investigational strategies for targeted therapies.
Activation of Wnt signaling by amniotic fluid stem cell-derived extracellular vesicles attenuates intestinal injury in experimental necrotizing enterocolitis
Authors: Li Bo , Lee Carol , O’Connell Joshua S. , Antounians Lina , Ganji Niloofar , Alganabi Mashriq , Cadete Marissa , Nascimben Francesca , Koike Yuhki , Hock Alison , Botts Steven R. , Wu Richard Y. , Miyake Hiromu , Minich Adam , Maalouf Michael F. , Zani-Ruttenstock Elke , Chen Yong , Johnson-Henry Kathene C. , De Coppi Paolo , Eaton Simon , Maattanen Pekka , Delgado Olguin Paul , Zani Augusto , Sherman Philip M. , Pierro Agostino 
Published: September 2020

AbstractNecrotizing enterocolitis (NEC) is a devastating intestinal disease primarily affecting preterm neonates and causing high morbidity, high mortality, and huge costs for the family and society. The treatment and the outcome of the disease have not changed in recent decades. Emerging evidence has shown that stimulating the Wnt/β-catenin pathway and enhancing intestinal regeneration are beneficial in experimental NEC, and that they could potentially be used as a novel treatment. Amniotic fluid stem cells (AFSC) and AFSC-derived extracellular vesicles (EV) can be used to improve intestinal injury in experimental NEC. However, the mechanisms by which they affect the Wnt/β-catenin pathway and intestinal regeneration are unknown. In our current study, we demonstrated that AFSC and EV attenuate NEC intestinal injury by activating the Wnt signaling pathway. AFSC and EV stimulate intestinal recovery from NEC by increasing cellular proliferation, reducing inflammation and ultimately regenerating a normal intestinal epithelium. EV administration has a rescuing effect on intestinal injury when given during NEC induction; however, it failed to prevent injury when given prior to NEC induction. AFSC-derived EV administration is thus a potential emergent novel treatment strategy for NEC.
Compound heterozygous variants in the ABCG8 gene in a Japanese girl with sitosterolemia
Authors: Hashimoto Nobuhiro , Dateki Sumito , Suzuki Eri , Tsuchihashi Takatoshi , Isobe Aiko , Banno Sari , Kageyama Tomoka , Maeda Naonori , Hatabu Naomi , Sato Rieko , Miharu Masashi , Fujita Hisayo , Komiyama Osamu , Shimizu Hitomi , Hasegawa Tomonobu , Yamazawa Kazuki 
Published: September 2020

AbstractSitosterolemia is an autosomal recessive disorder that affects lipid metabolism and is characterized by elevated serum plant sterol levels, xanthomas, and accelerated atherosclerosis. In this study, we report a novel nonsense single-nucleotide variant, c.225G > A (p.Trp75*), and an East Asian population-specific missense multiple-nucleotide variant, c.1256_1257delTCinsAA (p.Ile419Lys), in the ABCG8 gene in a compound heterozygous state observed in a Japanese girl with sitosterolemia.
Vertical organic synapse expandable to 3D crossbar array
Authors: Choi Yongsuk , Oh Seyong , Qian Chuan , Park Jin-Hong , Cho Jeong Ho 
Published: September 2020

AbstractRecently, three-terminal synaptic devices have attracted considerable attention owing to their nondestructive weight-update behavior, which is attributed to the completely separated terminals for reading and writing. However, the structural limitations of these devices, such as a low array density and complex line design, are predicted to result in low processing speeds and high energy consumption of the entire system. Here, we propose a vertical three-terminal synapse featuring a remote weight update via ion gel, which is also extendable to a crossbar array structure. This synaptic device exhibits excellent synaptic characteristics, which are achieved via precise control of ion penetration onto the vertical channel through the weight-control terminal. Especially, the applicability of the developed vertical organic synapse array to neuromorphic computing is demonstrated using a simple crossbar synapse array. The proposed synaptic device technology is expected to be an important steppingstone to the development of high-performance and high-density neural networks.
Chromatin accessibility mapping of the striatum identifies tyrosine kinase FYN as a therapeutic target for heroin use disorder
Authors: Egervari Gabor , Akpoyibo Diana , Rahman Tanni , Fullard John F. , Callens James E. , Landry Joseph A. , Ly Annie , Zhou Xianxiao , Warren Noël , Hauberg Mads E. , Hoffman Gabriel , Ellis Randy , Ferland Jacqueline-Marie N. , Miller Michael L. , Keller Eva , Zhang Bin , Roussos Panos , Hurd Yasmin L. 
Published: September 2020

AbstractThe current opioid epidemic necessitates a better understanding of human addiction neurobiology to develop efficacious treatment approaches. Here, we perform genome-wide assessment of chromatin accessibility of the human striatum in heroin users and matched controls. Our study reveals distinct neuronal and non-neuronal epigenetic signatures, and identifies a locus in the proximity of the gene encoding tyrosine kinase FYN as the most affected region in neurons. FYN expression, kinase activity and the phosphorylation of its target Tau are increased by heroin use in the post-mortem human striatum, as well as in rats trained to self-administer heroin and primary striatal neurons treated with chronic morphine in vitro. Pharmacological or genetic manipulation of FYN activity significantly attenuates heroin self-administration and responding for drug-paired cues in rodents. Our findings suggest that striatal FYN is an important driver of heroin-related neurodegenerative-like pathology and drug-taking behavior, making FYN a promising therapeutic target for heroin use disorder.
Caspase-8 mediates inflammation and disease in rodent malaria
Authors: Pereira Larissa M. N. , Assis Patrícia A. , de Araújo Natalia M. , Durso Danielle F. , Junqueira Caroline , Ataíde Marco Antônio , Pereira Dhelio B. , Lien Egil , Fitzgerald Katherine A. , Zamboni Dario S. , Golenbock Douglas T. , Gazzinelli Ricardo T. 
Published: September 2020

AbstractEarlier studies indicate that either the canonical or non-canonical pathways of inflammasome activation have a limited role on malaria pathogenesis. Here, we report that caspase-8 is a central mediator of systemic inflammation, septic shock in the Plasmodium chabaudi-infected mice and the P. berghei-induced experimental cerebral malaria (ECM). Importantly, our results indicate that the combined deficiencies of caspases-8/1/11 or caspase-8/gasdermin-D (GSDM-D) renders mice impaired to produce both TNFα and IL-1β and highly resistant to lethality in these models, disclosing a complementary, but independent role of caspase-8 and caspases-1/11/GSDM-D in the pathogenesis of malaria. Further, we find that monocytes from malaria patients express active caspases-1, -4 and -8 suggesting that these inflammatory caspases may also play a role in the pathogenesis of human disease.