bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preliminary Evidence on Measurement Characteristics for the Foundational Assessment of Competencies for Teaching Performance Tasks
Authors: Phelps Geoffrey , Bridgeman Brent , Yan Fred , Steinberg Jonathan , Weren Barbara , Zhou Jiawen 
Published: November 2020

In this report we provide preliminary evidence on the measurement characteristics for a new type of teaching performance assessment designed to be combined with complementary assessments of teacher content knowledge. The resulting test, which we refer to as the Foundational Assessment of Competencies for Teaching (FACT), is designed for use as part of initial teacher licensure. Twenty elementary FACT performance tasks (10 for mathematics [MATH] and 10 for reading language arts [RLA]) were developed and then administered to 59 teacher candidates. The results from the pilot indicate that the performance tasks function as designed with candidates completing the tasks on average in approximately 3.5 min. Human raters were able to score the tasks quickly and accurately. All score points were well represented for all the scored tasks. Total scores for all tasks combined and subscores for reading language arts RLA and MATH had respective alpha reliabilities of .86, .77, and .79, with the scores well distributed across the scale. A large majority of teacher candidates participating in the study strongly endorsed the FACT tasks as authentic, assessing valuable competencies, and suitable for use as part of teacher licensure. These preliminary results indicate that the FACT performance tasks show great promise for use in large‐scale, high‐stakes testing programs that seek to provide evidence of both the knowledge and skills needed for effective teaching.
Is the quality of reviews reflected in editors' and authors' satisfaction with peer review? A cross‐sectional study in 12 journals across four research fields
Authors: Pranić Shelly M. , Malički Mario , Marušić Stjepan Ljudevit , Mehmani Bahar , Marušić Ana 
Published: November 2020

AbstractPerception of review quality by authors and editors may play a vital role in helping to keep the peer review process constructive. Comprehensive studies examining author and editor perceptions of reviews of manuscripts from different disciplines are rare. We assessed satisfaction of corresponding authors and opinions of editors with reviewer‐generated reports and reviewers' recommendations and checked whether there was association between authors' and editors' perceptions and recommendations in 12 Elsevier journals across four disciplines. We used a modified Review Quality Instrument (RQI) to measure review quality for 809 unique manuscripts from which we accessed 1,313 reviews and recommendations, 331 authors' perception of the review's helpfulness before editor's decision, and 541 editor's opinions regarding both review timeliness and impact on decision. Authors were most satisfied with reviews that recommended acceptance compared to revision or rejection. Reviews that recommended revisions had highest quality as reflected by the RQI. Authors highly rated their satisfaction with review constructiveness from natural sciences, and editors for the same subject also highly rated timeliness and reviews' influence on publication. Editors' opinion regarding the impact of review on their publication decision and RQI were associated. Our findings suggest that more constructive reviews may better guide the editorial decision‐making process.
Assessment of carbapenem‐resistant Enterobacteriaceae—plate formula and quality control procedure
Authors: Tran Thanh C. , Pham Binh T. , Pham Van H. , Ngo The A. , Hanberger Håkan , Larsson Mattias , Olson Linus 
Published: November 2020

AbstractAimsTo assess a cost‐effective in‐house selective plate formula for actively screening carbapenem‐resistant Enterobacteriaceae (CRE).Methodology and resultsThe in‐house formula included CHROMagarTM Orientation, meropenem, and ingredients present in the Mac‐Conkey formula, such as bile salts and crystal violet (pH 6.9‐7.2). American Type Culture Collection strains and 200 clinical strains were used to validate the plate formula. The CRE plates had a sensitivity of 97.4% and a specificity of 98.8% with ATCC andor clinical strains used in the quality control procedure. A point prevalence survey among the 18 inpatients at Viet‐Tiep hospital ICU using fecal swabs plated at the in‐house agar plate showed a CRE prevalence of 44.4%.ConclusionThe in‐house plate had high sensitivity and specificity, particularly for Escherichia coli and the KESC group (Klebsiella spp., Enterobacter spp., Serratia marscescens, and Citrobacter spp.), and it may be widely applied as an alternative to other ready‐to‐use commercial plates.Significance and impact of the studyThe formula developed in the present study may facilitate the early detection and isolation of CRE and decrease transmission, particularly in low‐ and middle‐income countries with a high rate of CRE colonization and limited access to ready‐to‐use commercial plates.
Levodopa Versus Dopamine Agonist after Subthalamic Stimulation in Parkinson's Disease
Authors: Picillo Marina , Phokaewvarangkul Onanong , Poon Yu‐Yan , McIntyre Cameron C. , Beylergil Sinem Balta , Munhoz Renato P. , Kalia Suneil K. , Hodaie Mojgan , Lozano Andres M. , Fasano Alfonso 
Published: November 2020

AbstractBackgroundNo clinical trials have been specifically designed to compare medical treatments after surgery in Parkinson's disease (PD).ObjectiveStudy's objective was to compare the efficacy and safety of levodopa versus dopamine agonist monotherapy after deep brain stimulation (DBS) in PD.MethodsThirty‐five surgical candidates were randomly assigned to receive postoperative monotherapy with either levodopa or dopamine agonist in a randomized, single‐blind study. All patients were reevaluated in short‐ (3 months), mid‐ (6 months), and long‐term (2.5 years) follow‐up after surgery. The primary outcome measure was the change in the Non‐Motor Symptoms Scale (NMSS) 3 months after surgery. Secondary outcome measures were the percentage of patients maintaining monotherapy, change in motor symptoms, and specific non‐motor symptoms (NMS). Analysis was performed primarily in the intention‐to‐treat population.ResultsRandomization did not significantly affect the primary outcome (difference in NMSS between treatment groups was 4.88 [95% confidence interval: −11.78–21.53, P = 0.566]). In short‐ and mid‐term follow‐up, monotherapy was safe and feasible in more than half of patients (60% in short‐ and 51.5% in mid‐term follow‐up), but it was more often possible for patients on levodopa. The ability to maintain dopamine agonist monotherapy was related to optimal contact location. In the long term, levodopa monotherapy was feasible only in a minority of patients (34.2%), whereas dopamine agonist monotherapy was not tolerated due to worsening of motor conditions or occurrence of impulse control disorders.ConclusionsThis trial provides evidence for simplifying pharmacological treatment after functional neurosurgery for PD. The reduction in dopamine receptor agonists should be attempted while monitoring for occurrence of NMSs, such as apathy and sleep disturbances. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society
A novel mutation in PLS3 causes extremely rare X‐linked osteogenesis imperfecta
Authors: Hu Jing , Li Lu‐jiao , Zheng Wen‐bin , Zhao Di‐chen , Wang Ou , Jiang Yan , Xing Xiao‐ping , Li Mei , Xia Weibo 
Published: November 2020

AbstractBackgroundOsteogenesis imperfecta (OI) is a phenotypically and genetically heterogeneous bone disease characterized by bone fragility and recurrent fractures. X‐linked inherited OI with mutation in PLS3 is so rare that its genotype–phenotype characteristics are not available.MethodsWe designed a novel targeted next‐generation sequencing (NGS) panel with the candidate genes of OI to detect pathogenic mutations and confirmed them by Sanger sequencing. The phenotypes of the patients were also investigated.ResultsThe proband, a 12‐year‐old boy from a nonconsanguineous family, experienced multiple fractures of long bones and vertebrae and had low bone mineral density (BMD Z‐score of −3.2 to −2.0). His younger brother also had extremity fractures. A novel frameshift mutation (c.1106_1107insGAAA; p.Phe369Leufs*5) in exon 10 of PLS3 was identified in the two patients, which was inherited from their mother who had normal BMD. Blue sclerae were the only extraskeletal symptom in all affected individuals. Zoledronic acid was beneficial for increasing BMD and reshaping the compressed vertebral bodies of the proband.ConclusionWe first identify a novel mutation in PLS3 that led to rare X‐linked OI and provide practical information for the diagnosis and treatment of this disease.
The optimal homotopy analysis method applied on nonlinear time‐fractional hyperbolic partial differential equations
Authors: Bahia Ghenaiet , Ouannas Adel , Batiha Iqbal M. , Odibat Zaid 
Published: November 2020

AbstractIn this article, the most recent version of an optimal homotopy analysis method (HAM), called linearization‐based approach of HAM or simply LHAM, has been applied to obtain a numerical solution of one of the principal nonlinear fractional‐order hyperbolic problems known as the time‐fractional hyperbolic partial differential equation. Such method is constructed based on employing Taylor series linearization method in order to design an optimal auxiliary linear operator with its corresponding optimal initial guessing. These two optimum contributors will accelerate the convergence of series solutions for the problem at hand. Several numerical comparisons have revealed the efficiency of the proposed method in obtaining a numerical solution of the problem rather than that solution presented by using the standard HAM. All theoretical findings in this work have been verified numerically using MATLAB software package.
Maize brace roots provide stalk anchorage
Authors: Reneau Jonathan W. , Khangura Rajdeep S. , Stager Adam , Erndwein Lindsay , Weldekidan Teclemariam , Cook Douglas D. , Dilkes Brian P. , Sparks Erin E. 
Published: November 2020

AbstractMechanical failure, known as lodging, negatively impacts yield and grain quality in crops. Limiting crop loss from lodging requires an understanding of the plant traits that contribute to lodging‐resistance. In maize, specialized aerial brace roots are reported to reduce root lodging. However, their direct contribution to plant biomechanics has not been measured. In this manuscript, we use a non‐destructive field‐based mechanical test on plants before and after the removal of brace roots. This precisely determines the contribution of brace roots to establish a rigid base (i.e. stalk anchorage) that limits plant deflection in maize. These measurements demonstrate that the more brace root whorls that contact the soil, the greater their overall contribution to anchorage, but that the contributions of each whorl to anchorage were not equal. Previous studies demonstrated that the number of nodes that produce brace roots is correlated with flowering time in maize. To determine if flowering time selection alters the brace root contribution to anchorage, a subset of the Hallauer's Tusón tropical population was analyzed. Despite significant variation in flowering time and anchorage, selection neither altered the number of brace root whorls in the soil nor the overall contribution of brace roots to anchorage. These results demonstrate that brace roots provide a rigid base in maize and that the contribution of brace roots to anchorage was not linearly related to flowering time.
The impact of chronic obstructive pulmonary disease in patients' lives: The perception of the health professionals
Authors: Rafaelli de Carvalho Débora , Araújo de Castro Larissa , Morita Andrea Akemi , Loyola Walter Sepúlveda , Fujisawa Dirce Shizuko , Probst Vanessa Suziane 
Published: November 2020

AbstractIntroductionThe perception of health professionals about chronic obstructive pulmonary disease (COPD) has not been thoroughly investigated.ObjectiveTo analyze the perception of health professionals about the impact of COPD on the lives of affected individuals.Materials and methodsQualitative and cross‐sectional study with five health professionals: two nurses, two physiotherapists, and one medical doctor. They participated in a focus group (FG) session, with semistructured questions covering: definition of COPD, activities of daily living (ADL), and physical activity of daily living (PADL), as well as the importance of these outcomes in the lives of individuals with COPD.Data analysisThe FG was recorded, transcribed, and analyzed according to the content analysis.ResultsThe FG highlighted four main themes: physical‐functional and emotional impairment of individuals, the importance of patient‐health professional contact, repercussions of COPD on the patients' physical activity, and strategies for promoting physical activity. Based on the four themes exposed, the health professionals reported that there is a progression in the lives of individuals' with COPD, which is divided into three phases: adaptation, reluctance, and dependence.ConclusionThere was a negative perception of the health professionals regarding the functionality and emotion of patients with COPD. Emotional aspects, family support, and architectural structure can positively or negatively influence patients' ADL and PADL. Finally, there was a perception of progression in the life of patients with COPD, since their initial adaptation, evolving to physical and emotional dependence.
Nanodiscs: A toolkit for membrane protein science
Authors: Sligar Stephen G. , Denisov Ilia G. 
Published: November 2020

AbstractMembrane proteins are involved in numerous vital biological processes, including transport, signal transduction and the enzymes in a variety of metabolic pathways. Integral membrane proteins account for up to 30% of the human proteome and they make up more than half of all currently marketed therapeutic targets. Unfortunately, membrane proteins are inherently recalcitrant to study using the normal toolkit available to scientists, and one is most often left with the challenge of finding inhibitors, activators and specific antibodies using a denatured or detergent solubilized aggregate. The Nanodisc platform circumvents these challenges by providing a self‐assembled system that renders typically insoluble, yet biologically and pharmacologically significant, targets such as receptors, transporters, enzymes, and viral antigens soluble in aqueous media in a native‐like bilayer environment that maintain a target's functional activity. By providing a bilayer surface of defined composition and structure, Nanodiscs have found great utility in the study of cellular signaling complexes that assemble on a membrane surface. Nanodiscs provide a nanometer scale vehicle for the in vivo delivery of amphipathic drugs, therapeutic lipids, tethered nucleic acids, imaging agents and active protein complexes. This means for generating nanoscale lipid bilayers has spawned the successful use of numerous other polymer and peptide amphipathic systems. This review, in celebration of the Anfinsen Award, summarizes some recent results and provides an inroad into the current and historical literature.
Frontlines of COVID‐19: Lead, learn and cure
Authors: Kadri Shakeel , Davis Ana , Clancy Cornelius , Payne James David , Klejst Stephen 
Published: November 2020

AbstractWe are very pleased and privileged to share this article that was developed from the “Frontlines of COVID‐19: Lead, Learn and Cure” panel discussion held at the virtual AIChE 2020 Spring Meeting and GCPS. The intent of this panel was to have a team of diversified experts share their experience in managing COVID‐19 risks through the application of robust corporate leadership and culture, transformational incident investigation techniques, recent learnings from medicinal developments, as well as highlight the important role of the scientific community in the management of COVID‐19 risks.
Localization for precision navigation in agricultural fields—Beyond crop row following
Authors: Winterhalter Wera , Fleckenstein Freya , Dornhege Christian , Burgard Wolfram 
Published: November 2020

AbstractThe growing world population calls for more efficient and sustainable farming technologies. Automating agricultural tasks has great potential to improve farming technologies. A key requirement for full automation is the ability of agricultural vehicles to accurately navigate entire fields without damaging value crops. One important precondition for autonomous navigation is localization, that is, the ability of a vehicle to accurately estimate its pose relative to the crops. A majority of localization approaches detect crop rows to track the heading and lateral offset of the vehicle. This is sufficient to guide the vehicle along crop rows while driving inside the field. However, switching between rows requires a longitudinal pose estimate to determine when to turn at the end of the field. Additionally, at the end of the field sensor data contains less crop row structure and more noise from wild growing vegetation. This can lead to false‐positive crop row detections. In this paper, we present a localization approach that goes beyond state‐of‐the‐art crop row following algorithms by providing robust pose estimates not only inside the field but also at the end of the field. The underlying concept of our approach is to estimate the vehicle pose relative to a global navigation satellite system (GNSS)‐referenced map of crop rows. This allows us to fuse crop row detections with GNSS signals to obtain a pose estimate with the accuracy comparable to a row following approach in the heading and lateral offset, while at the same time maintaining at least GNSS accuracy along the row. Employing a GNSS‐referenced map of crop rows poses several challenges. To relate the detected crop rows to those in the map, we propose a data association strategy that finds correspondences between two sets of lines, that is, crop rows. Furthermore, we improve the GNSS‐based longitudinal pose estimate by detecting the end of the field from vegetation data. Additionally, we introduce a novel method to determine false‐positive crop row detections to increase the overall robustness in particular in challenging scenarios at the end of the field. Extensive real‐world experiments on three different types of crops demonstrate that our localization approach is well suited for fully autonomous navigation in entire fields.
Impact of cancer history on clinical outcome in patients undergoing transcatheter edge-to-edge mitral repair
Authors: Tabata Noriaki , Weber Marcel , Sugiura Atsushi , Öztürk Can , Tsujita Kenichi , Nickenig Georg , Sinning Jan-Malte 
Published: November 2020

AbstractBackgroundLittle is known about the prevalence of a history of cancer and its impact on clinical outcome in mitral regurgitation (MR) patients undergoing transcatheter mitral valve repair (TMVR).ObjectivesThe purpose of this study is to investigate the prevalence of cancer, baseline inflammatory parameters, and clinical outcome in MR patients undergoing TMVR.MethodsConsecutive patients undergoing a MitraClip procedure were enrolled, and the patients were stratified into two groups: cancer and non-cancer. Baseline complete blood counts (CBC) with differential hemograms were collected prior to the procedure to calculate the platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR). All-cause death within a one-year was examined.ResultsIn total, 82 out of 446 patients (18.4%) had a history of cancer. Cancer patients had a significantly higher baseline PLR [181.4 (121.1–263.9) vs. 155.4 (109.4–210.4);P = 0.012] and NLR [5.4 (3.5–8.3) vs. 4.0 (2.9–6.1);P = 0.002] than non-cancer patients. A Kaplan–Meier analysis revealed that cancer patients had a significantly worse prognosis than non-cancer (estimated 1-year mortality, 20.2 vs. 9.2%; log-rankP = 0.009), and multivariable analyses of three models showed that cancer history was an independent factor for 1-year mortality. Patients who died during follow-up had a significantly higher baseline PLR [214.2 (124.2–296.7) vs. 156.3 (110.2–212.1);P = 0.007] and NLR [6.4 (4.2–12.5) vs. 4.0 (2.9–6.2);P < 0.001] than survivors.ConclusionsIn MitraClip patients, a history of cancer was associated with higher inflammatory parameters and worse prognosis compared to non-cancer patients.Graphical AbstractCentral Illustration. Clinical outcomes and baseline PLR and NLR values accord-ing to one-year mortality. (Left) Patients who died within the follow-up period had a significantly higher baseline PLR (214.2 [124.2–296.7] vs 156.3 [110.2–212.1];P= 0.007) and NLR (6.4 [4.2–12.5] vs 4.0 [2.9–6.2];P< 0.001) than patients who survived. PLR, platelet-to-lymphocyte ratio; NLR, neutrophil-to-lymphocyte ratio (Right) A Kaplan-Meier analysis revealed that cancer patients had a significantly worse prognosis than non-cancer patients (estimated one-year mortality, 20.2 vs 9.2%; log-rankP= 0.009).
Do discontinuities in marginal reimbursement affect inpatient psychiatric care in Germany?
Authors: Pott Clara , Stargardt Tom , Schneider Udo , Frey Simon 
Published: November 2020

AbstractThis paper examines the behaviour of mental health care providers in response to marginal payment incentives induced by a discontinuous per diem reimbursement schedule with varying tariff rates over the length of stay. The analyses use administrative data on 12,627 cases treated in 82 psychiatric hospitals and wards in Germany. We investigate whether substantial reductions in marginal reimbursement per inpatient day led to strategic discharge behaviour once a certain length of stay threshold is exceeded. The data do not show gaps and bunches at the duration of treatment when marginal reimbursement decreases. Using logistic regression models, we find that providers did not react to discontinuities in marginal reimbursement by significantly reducing inpatient length of stay around the threshold. These findings are robust in terms of different model specifications and subsamples. The results indicate that if regulators aim to set incentives to decrease LOS, this might not be achieved by cuts in reimbursement over LOS.
Implementing and modifying Broyden class updates for large scale optimization
Authors: Buhmann Martin , Siegel Dirk 
Published: November 2020

AbstractWe consider Broyden class updates for large scale optimization problems in n dimensions, restricting attention to the case when the initial second derivative approximation is the identity matrix. Under this assumption we present an implementation of the Broyden class based on a coordinate transformation on each iteration. It requires only $$2nk + O(k^{2}) + O(n)$$

2
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k
+
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(

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+
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multiplications on the kth iteration and stores $$nK+ O(K^2) + O(n)$$

n
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(

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+
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numbers, where K is the total number of iterations. We investigate a modification of this algorithm by a scaling approach and show a substantial improvement in performance over the BFGS method. We also study several adaptations of the new implementation to the limited memory situation, presenting algorithms that work with a fixed amount of storage independent of the number of iterations. We show that one such algorithm retains the property of quadratic termination. The practical performance of the new methods is compared with the performance of Nocedal’s (Math Comput 35:773--782, 1980) method, which is considered the benchmark in limited memory algorithms. The tests show that the new algorithms can be significantly more efficient than Nocedal’s method. Finally, we show how a scaling technique can significantly improve both Nocedal’s method and the new generalized conjugate gradient algorithm.