bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute kidney injury in patients with SARS-CoV-2 infection
Authors: Joseph Adrien , Zafrani Lara , Mabrouki Asma , Azoulay Elie , Darmon Michael 
Published: September 2020

AbstractBackgroundAcute Kidney Injury (AKI) is a frequent complication of severe SARS-CoV-2 infection. Multiple mechanisms are involved in COVID-19-associated AKI, from direct viral infection and secondary inflammation to complement activation and microthrombosis. However, data are limited in critically-ill patients. In this study, we sought to describe the prevalence, risk factors and prognostic impact of AKI in this setting.MethodsRetrospective monocenter study including adult patients with laboratory confirmed SARS-CoV-2 infection admitted to the ICU of our university Hospital. AKI was defined according to both urinary output and creatinine KDIGO criteria.ResultsOverall, 100 COVID-19 patients were admitted. AKI occurred in 81 patients (81%), including 44, 10 and 27 patients with AKI stage 1, 2 and 3 respectively. The severity of AKI was associated with mortality at day 28 (p = 0.013). Before adjustment, the third fraction of complement (C3), interleukin-6 (IL-6) and ferritin levels were higher in AKI patients. After adjustment for confounders, both severity (modified SOFA score per point) and AKI were associated with outcome. When forced in the final model, C3 (OR per log 0.25; 95% CI 0.01–4.66), IL-6 (OR per log 0.83; 95% CI 0.51–1.34), or ferritin (OR per log 1.63; 95% CI 0.84–3.32) were not associated with AKI and did not change the model.ConclusionIn conclusion, we did not find any association between complement activation or inflammatory markers and AKI. Proportion of patients with AKI during severe SARS-CoV-2 infection is higher than previously reported and associated with outcome.
Coverless information hiding based on the generation of anime characters
Authors: Cao Yi , Zhou Zhili , Wu Q. M. Jonathan , Yuan Chengsheng , Sun Xingming 
Published: September 2020

AbstractTo fundamentally resist the steganalysis, coverless information hiding has been proposed, and it has become a research hotspot in the field of covert communication. However, the current methods not only require a huge image database, but also have a very low hidden capacity, making it difficult to apply practically. In order to solve the above problems, we propose a coverless information hiding method based on the generation of anime characters, which first converts the secret information into an attribute label set of the anime characters, and then uses the label set as a driver to directly generate anime characters by using the generative adversarial networks (GANs). The experimental results show that compared with the current methods, the hidden capacity of the proposed method is improved by nearly 60 times, and it also has good performance in image quality and robustness.
Regularization of the fractional Rayleigh–Stokes equation using a fractional Landweber method
Authors: Luc Nguyen Hoang , Huynh Le Nhat , O’Regan Donal , Can Nguyen Huu 
Published: September 2020

AbstractIn this paper, we consider a time-fractional backward problem for the fractional Rayleigh–Stokes equation in a general bounded domain. We propose a fractional Landweber regularization method for solving this problem. Error estimates between the regularized solution and the sought solution are also obtained under some choice rules for both a-priori and a-posterior regularization parameters.
On a new fixed point theorem with an application on a coupled system of fractional differential equations
Authors: Afshari Hojjat , Jarad Fahd , Abdeljawad Thabet 
Published: September 2020

AbstractIn this work, new theorems and results related to fixed point theory are presented. The results obtained are used for the sake of proving the existence and uniqueness of a positive solution of a coupled system of equations that involves fractional derivatives in the Riemann–Liouville settings and is subject to boundary conditions in the form of integrals.
Certain new weighted estimates proposing generalized proportional fractional operator in another sense
Authors: Abdeljawad Thabet , Rashid Saima , El-Deeb A. A. , Hammouch Zakia , Chu Yu-Ming 
Published: September 2020

AbstractThe present work investigates the applicability and effectiveness of generalized proportional fractional integral ($\mathcal{GPFI}$
GPFI
) operator in another sense. We aim to derive novel weighted generalizations involving a family of positive functions n ($n\in \mathbb{N}$
n
∈
N
) for this recently proposed operator. As applications of this operator, we can generate notable outcomes for Riemann–Liouville ($\mathcal{RL}$
RL
) fractional, generalized $\mathcal{RL}$
RL
-fractional operator, conformable fractional operator, Katugampola fractional integral operator, and Hadamard fractional integral operator by changing the domain. The proposed strategy is vivid, explicit, and it can be used to derive new solutions for various fractional differential equations applied in mathematical physics. Certain remarkable consequences of the main theorems are also figured.
Effects of decitabine on allogeneic immune reactions of donor lymphocyte infusion via activation of dendritic cells
Authors: Kwon Yong-Rim , Kim Hye Joung , Sohn Min-Jung , Lim Ji-Young , Park Kyung-Shin , Lee Seok , Chung Nack-Gyun , Jeong Dae-Chul , Min Chang-Ki , Kim Yoo-Jin 
Published: September 2020

AbstractBackgroundSuccessful prevention of post-transplantation relapse after donor lymphocyte infusion (DLI) depends on its capability to mediate an effective graft-versus-leukemia (GVL) response while minimizing DLI-related toxicity, including graft-versus-host disease (GVHD).MethodsWe assessed the effects of decitabine (DEC), a hypomethylating agent, upon allogeneic immune reaction in a murine model of DLI.ResultsSignificantly greater tumor growth retardation and survival prolongation occurred in mice administered with 1.0 mg/kg DEC for 5 days (DEC-1.0) than in control or DEC-0.1 mice. Upon prompt DEC and DLI co-administration, dendritic cells (DCs) were activated; DEC-1.0/DLI induced severe GVHD, and survival was significantly lower than with DLI alone or DEC-0.1/DLI treatments. IFN-γ and CD28 levels were higher in splenic DCs of DEC-1.0 mice than in those of control mice. Assessment of delayed DLI co-administration with DEC, when IFN-γ levels were normalized to control levels, revealed that DEC-1.0/DLI successfully facilitated tumor management without causing severe GVHD.ConclusionsOur results suggest that DEC primes allogeneic immune reactions of DLI via DC activation, and GVHD and GVL effects are separable through optimal DLI timing based on DEC-induced increase in IFN-γ expression levels.
“I’m not a teenager, I’m 22. Why can’t I snap out of it?”: a qualitative exploration of seeking help for a first-episode eating disorder during emerging adulthood
Authors: Potterton Rachel , Austin Amelia , Allen Karina , Lawrence Vanessa , Schmidt Ulrike 
Published: September 2020

Abstract
Background
Eating disorders (EDs) typically have their onset during adolescence or the transition to adulthood. Emerging adulthood (~ 18–25 years) is a developmental phase which conceptually overlaps with adolescence but also has unique characteristics (e.g. increased independence). Emerging adults tend to come to ED services later in illness than adolescents, and emerging adulthood’s unique characteristics may contribute to such delays.

Objective
This study aimed to explore attitudes towards ED symptoms, and their implications for help-seeking, amongst emerging adults receiving ED treatment through FREED, an early intervention care pathway.

Method
Participants were 14 emerging adults (mean age 20.9 years; SD = 2.0), all currently receiving specialist treatment for a first-episode, recent-onset (< 3 years) ED. Semi-structured interviews relating to experiences of help-seeking were conducted, and data were analysed thematically.

Results
Symptom egosyntonicity, gradual reappraisal and feelings of exclusion from ED discourse were key attitudinal phases prior to help-seeking, each of which had distinct implications for help-seeking.

Conclusions
Emerging adults with first-episode EDs show a distinct set of help-seeking-related challenges and opportunities (e.g. help-seeking for others; help-seeking at transitions; self-sufficiency). This research might be used to inform the development and evaluation of interventions which aim to facilitate help-seeking amongst emerging adults with first-episode recent-onset EDs.
Validation of the inhaler adherence questionnaire
Authors: Toelle Brett G. , Marks Guy B. , Dunn Stewart M. 
Published: September 2020

AbstractBackgroundAlthough electronic monitoring is the “gold standard” for adherence monitoring, the range of inhaler devices on the market exceeds the availability of appropriate monitoring devices. Simple tools, applicable across a range of inhalers, are needed to assess patients’ adherence to prescribed inhaled medication. This study reports on the validation of an Inhaler Adherence Questionnaire (IAQ).MethodsSeventy-four adults who self-reported doctor diagnosed asthma and who were prescribed daily inhaled corticosteroids (ICS) for asthma contributed data for these analyses. These participants were part of a larger study, investigating factors associated with non-adherence to prescribed daily inhaled corticosteroid medication. Participants were informed the research was investigating asthma management without explicit mention that medication adherence was being monitored. Inhaled corticosteroid medication adherence was measured in two ways. Firstly, participants completed the 6-item IAQ at enrolment. Secondly, ICS via pressurised Metered Dose Inhaler (pMDI) use was monitored electronically using the DoserCT which recorded daily use over 6 weeks. During the 6 weeks of prospective medication monitoring via the DoserCT we did not have contact with participants so that the adherence measure would reflect usual self-management behaviour.ResultsTwo of the six questions in the IAQ had poor face validity and their exclusion from the questionnaire resulted in improved internal consistency. Mean days adherent were 37.1, 29.2 and 33.2% for subjects with IAQ scores of 0, 1 and 2 respectively. Higher IAQ scores of 3 and 4 were associated with greater mean days adherent of 73.7 and 67.4% respectively. A cut-point of 2 or less had a sensitivity of 73% and a specificity of 80% for detecting non-adherence. The area under the ROC curve was 0.764 (p < 0.001).ConclusionsThe modified 4-item IAQ is simple, quick to complete and useful for measuring adherence with prescribed daily inhaled medication. This validation of the IAQ provides evidence for its utility in research and it will be important to validate this simple, inexpensive tool for use in clinical practice.
Untangling the origin and function of granulovacuolar degeneration bodies in neurodegenerative proteinopathies
Authors: Wiersma Vera I. , Hoozemans Jeroen J. M. , Scheper Wiep 
Published: September 2020

AbstractIn the brains of tauopathy patients, tau pathology coincides with the presence of granulovacuolar degeneration bodies (GVBs) both at the regional and cellular level. Recently, it was shown that intracellular tau pathology causes GVB formation in experimental models thus explaining the strong correlation between these neuropathological hallmarks in the human brain. These novel models of GVB formation provide opportunities for future research into GVB biology, but also urge reevaluation of previous post-mortem observations. Here, we review neuropathological data on GVBs in tauopathies and other neurodegenerative proteinopathies. We discuss the possibility that intracellular aggregates composed of proteins other than tau are also able to induce GVB formation. Furthermore, the potential mechanisms of GVB formation and the downstream functional implications hereof are outlined in view of the current available data. In addition, we provide guidelines for the identification of GVBs in tissue and cell models that will help to facilitate and streamline research towards the elucidation of the role of these enigmatic and understudied structures in neurodegeneration.
Impact of rail transit station proximity to commercial property prices: utilizing big data in urban real estate
Authors: Berawi Mohammed Ali , Miraj Perdana , Saroji Gunawan , Sari Mustika 
Published: September 2020

AbstractUrban transport investments have contributed to the exponential increase of value from land and properties around the built infrastructure. Although literature had shown evidence of value uplift from the residential property due to transit development, little is known about the impact on commercial property values. This paper aims to evaluate the impact of rail transit proximity to the commercial property market by taking into account the pre-operation of the LRT project in Jakarta, Indonesia. This study utilizes a big data approach to accelerate research data processing by employing data mining method, as well as geographical information system (GIS) and hedonic price modeling (HPM) to investigate the property prices to formulate empirical evidence for the research. The results show opposite evidence compared to previous studies which argued that accessibility may contribute to the property price when closer to the transit station. The findings indicate that proximity to rail transit has an insignificant impact on the commercial property price compared to other variables such as building size, number of rooms, location, and hospitals. A comparison of the findings between this research with other studies was discussed and recommendation for further research development was proposed.
Large-scale forecasting of information spreading
Authors: Severiukhina Oksana , Kesarev Sergey , Bochenina Klavdiya , Boukhanovsky Alexander , Lees Michael H. , Sloot Peter M. A. 
Published: September 2020

AbstractThis research proposes a system based on a combination of various components for parallel modelling and forecasting the processes in networks with data assimilation from the real network. The main novelty of this work consists of the assimilation of data for forecasting the processes in social networks which allows improving the quality of the forecast. The social network VK was considered as a source of information for determining types of entities and the parameters of the model. The main component is the model based on a combination of internal sub-models for more realistic reproduction of processes on micro (for single information message) and meso (for series of messages) levels. Moreover, the results of the forecast must not lose their relevance during the calculations. In order to get the result of the forecast for networks with millions of nodes in reasonable time, the process of simulation has been parallelized. The accuracy of the forecast is estimated by MAPE, MAE metrics for micro-scale, the Kolmogorov–Smirnov criterion for aggregated dynamics. The quality in the operational regime is also estimated by the number of batches with assimilated data to achieve the required accuracy and the ratio of calculation time in the frames of the forecasting period. In addition, the results include experimental studies of functional characteristics, scalability, as well as the performance of the system.
Inventory management performance for laboratory commodities in public hospitals of Jimma zone, Southwest Ethiopia
Authors: Befekadu Abdi , Cheneke Waqtola , Kebebe Dereje , Gudeta Tadesse 
Published: September 2020

Abstract
Background
Maintaining an efficient and effective inventory management system ensures a reliable supply of laboratory commodities. The aim of this study was, therefore, to assess the performance of inventory management for laboratory commodities in public hospitals in the Jimma zone.

Methods
A facility-based cross-sectional descriptive study, accompanied by a qualitative method, was conducted in seven public hospitals between April 30 and May 29, 2019. We collected data through document reviews (225 bin-cards), physical observation, self-administered questionnaires, and in-depth interviews. The quantitative data were analyzed using Excel spreadsheets and SPSS version 24. Fifteen key informants of different backgrounds took part in the qualitative study. The data were then analyzed using thematic analysis techniques.

Results
All the public hospitals in the zone were included in the study, making a response rate of 100%. Of the total estimated bin-cards, 225 (69.9%) of them held along with the items, and only 30.4% of them filled accurately. In four of the hospitals, pharmacists determined how much to order. Five of the hospitals used average monthly consumption data to calculate purchase quantity. Over the past 6 months, four of the hospitals had placed at least one or two emergency orders. The wastage rate of the commodities in the hospitals was 27.2% and resulted in a loss of about 10,248.5 US dollars. The hospitals had met 70.6% of the criteria for proper storage conditions. Budget constraints, absence of prompt administrative support, lack of staff commitment, and frequent shortages of commodities on the part of suppliers were major bottlenecks of inventory management.

Conclusions
The hospitals had weak inventory management practices, showed by inaccurate records, stock-outs (frequent emergency orders), a high wastage rate compared to national baseline statistics, and the storage conditions below the standard.
Platelet-rich plasma (PRP) as therapy for cartilage, tendon and muscle damage – German working group position statement
Authors: Tischer T. , Bode G. , Buhs M. , Marquass B. , Nehrer S. , Vogt S. , Zinser W. , Angele P. , Spahn G. , Welsch G. H. , Niemeyer P. , Madry H. 
Published: September 2020

Abstract
Purpose
Platelet rich plasma (PRP) is widely used in orthopaedics, but is still heavily debated. Therefore, a survey among the German “Working Group for Clinical Tissue Regeneration” of the German Society of Orthopaedics and Traumatology was conducted to achieve a consensus about the current therapeutical potential of PRP.

Methods
A first survey (n = 65 experts, all orthopaedic/trauma surgeons) was conducted (n = 13 questions). Following, a second round (n = 40 experts) was conducted with 31 questions to achieve consensus in 5 categories: three most common indications, PRP application, future research areas.

Results
Therapeutic PRP application was regarded as useful (89%), possibly even more important in the future (90%). Most common indications were tendon pathologies (77%), osteoarthritis (OA) (68%), muscle injuries (57%) and cartilage damage (51%). Consensus was reached in 16/31 statements. The application of PRP for early knee OA (Kellgren-Lawrence grade II) was regarded as potentially useful, as well as for acute and chronic tendinopathies. For chronic lesions (cartilage, tendons), multiple injections (2–4) were seen preferable to singular injections. However, no sufficient data exists on the time interval between the injections. Standardization of PRP preparation, application, frequency, as well as determining the range of indication is strongly recommended.

Conclusions
There is a need of further standardization of the PRP preparation methods, indication and application protocols for knee OA and other indications, which must be further evaluated in basic science studies and randomized controlled clinical trials.

Level of evidence
Consensus of expert opinion, Level V.
From a PMT-based to a SiPM-based PET system: a study to define matched acquisition/reconstruction parameters and NEMA performance of the Biograph Vision 450
Authors: Carlier Thomas , Ferrer Ludovic , Conti Maurizio , Bodet-Milin Caroline , Rousseau Caroline , Bercier Yanic , Bendriem Bernard , Kraeber-Bodéré Françoise 
Published: September 2020

Abstract
Background
The purpose of this work was to propose an approach based on noise measurement to adapt present clinical acquisition and reconstruction parameters adapted to a PMT-based system (Biograph mCT) to a SiPM-based system (Biograph Vision 450) sharing identical geometrical properties. The NEMA performance (NEMA) of the recently released Biograph Vision 450 PET/CT (Vision) was also derived.

Methods
All measurements were conducted on Vision and Biograph mCT with TrueV (mCT). A full NEMA-based performance was derived for Vision only. The adaptation of acquisition and reconstruction parameters from mCT to Vision was done using the NEMA image quality phantom. The noise level reached using mCT was set as the reference value for six different numbers of net true coincidences. The noise level computed using Vision was matched to the reference noise level (within 0.01%) using a different reconstruction set-up to determine the potential reduction of count numbers for the same noise level.

Results
Vision sensitivity was 9.1 kcps/MBq for a timing resolution of 213 ps at 5.3 kBq/mL. The NEMA-based CR for the 10-mm sphere was better than 75% regardless the reconstruction set-up studied. The mCT reference noise properties could be achieved using Vision with a scan time reduction (STR) of 1.34 with four iterations and a 440 × 440 matrix size (or STR = 1.89 with a 220 × 220 matrix size) together with a 3D CR improvement of 53% for the 10-mm sphere (24% using 220 × 220).

Conclusion
The Vision exhibited improved NEMA performances compared to mCT. Using the proposed approach, the time acquisition could be divided by almost two, while keeping the same noise properties as that of mCT with a marked improvement of contrast recovery.
Estimation of liquefaction potential in Eco-Delta City (Busan) using different approaches with effect of fines content
Authors: Bahari Bahareh , Hwang Woongki , Kim Tae-Hyung , Song Young-Suk 
Published: September 2020

AbstractSoil liquefaction which is a disastrous phenomenon induced by the earthquake, is widely investigated in many researches in geotechnical engineering. In this study, a SPT-N based investigation is carried out to assess the susceptibility of liquefaction in Eco-Delta city, located in the southwestern part of Busan city in South Korea. Data from 229 sites are analyzed for the earthquake of 7.5 magnitude with a peak horizontal acceleration of 0.2 g to carry out the liquefaction potential index (LPI) through two deterministic methods which have different factors of safety (FS). The liquefaction probability is investigated by the deterministic and reliability methods and the liquefaction hazard maps are generated. To observe the effect of fines content and plasticity index on the liquefaction susceptibility, three different cases are considered. It is found that among the four approaches used, Overseas Coastal Area Development Institute of Japan (OCDI) method showed more sensitivity to changes of fines content and plasticity index. The Eco-Delta city is found to be highly vulnerable to liquefaction having 91% of sites with LPI values greater than 15.
Timely mental health services contribute to the containment of COVID-19 pandemic in China
Authors: Zhang Ning , Wu Kankan , Wang Weidan 
Published: September 2020

AbstractThe COVID-19 pandemic is the most severe public health crisis in the 21st century. The pandemic not only posed great challenges to people's physical health but also induced wide-ranging impacts on mental health of infected and suspected patients, frontline healthcare workers, and the general public whose normal life was disrupted by the pandemic. In this commentary, we outline the initiatives and coordinated efforts on providing timely mental health services after the pandemic outbreak in China, including understanding the mental health impact of COVID-19, prioritizing and coordinating mental health services along with medical services in the efforts to contain the pandemic, initiating and implementing specific measures to improve mental wellbeing of frontline healthcare workers, and increasing the accessibility of mental health services to the general public. Theses services, along with other coordinated efforts, contribute to the containment of COVID-19 pandemic in China and could be valuable for other countries to take proactive measures to mitigate the mental health impacts of the pandemic now and in the future.