bluuebunny/crossref_metadata_2025_split huggingface dataset:
TAE Combined with Microwave Ablation in the Treatment of Rare Giant Hepatic Hemangioma:Case Report and Literature Review
Authors: Feng Yi-fu , Chen Xin-yi , Mo Jing-gang , Wu Hai-ling , Zhou Jian-yu , Jin Chong , Jiang Hao , Kun-Peng Wang 
Published: July 2020

Abstract
Background: hepatic hemangioma is the most common benign tumor of the liver. However, patients with large hemangiomas that cause compression symptoms or that are at risk of rupture may need further intervention. It is necessary to explore additional minimally invasive and personalized treatment options.Case presentation: A 47-year-old female was diagnosed with right hepatic hemangioma for more than 10 years. Abdominal contrast-enhanced CT and CEUS revealed that there was a large hemangioma in the right liver, with a size of approximately 95x97x117 mm. Due to the patient's refusal of surgical treatment, hepatic artery embolization was performed in the first stage, then after 25 days of liver protection treatment, the liver function indexes decreased to normal levels. Then, B-ultrasound-guided microwave ablation of the giant hepatic hemangioma was performed. Ten days after the surgery, hepatobiliary ultrasonography showed that the hemangioma of the right liver was smaller than the previous size (the volume was reduced by approximately 30%). Then the patient was discharged from the hospital, and CT suggested that the hepatic hemangioma is significantly smaller two months after discharge. Because of COVID-19, the patient's CT examination was delayed.Conclusions: TAE combined with microwave ablation is a safe and effective minimally invasive treatment for hepatic hemangioma.
Aggravated Primary Lymphedema of Contralateral Upper Limb after the Radical Mastectomy: A Case Report
Authors: Liu Ying , Pan Weiren , Guan Jinghong , Long Xiao 
Published: July 2020

Abstract
Background: Breast cancer-related lymphedema is usually characterized by edema of the affected the ipsilateral upper limb and trunk. We report a case of aggravated primary lymphedema in the contralateral limb and trunk after breast cancer resection and axillary lymph node dissection.Case presentation: A 63-year-old female developed right thorax-back and upper limb swelling since childhood. After the modified mastectomy, the swelling of her right chest, back and upper limb increased. While she had no edema of left torso and limb. There was no relevant supplementary examination data because she refused to take lymphoscintigraphy or MRI scan. However, according to her medical history and physical examination, she was preliminarily diagnosed as primary lymphedema, International Society of lymphedema stage 2.Conclusions: Primary lymphedema and secondary lymphedema may be both results of the interaction of multiple factors and can be induced or aggravated by trauma, surgery or other reasons besides the abnormal lymphatic development of individuals.
Peritoneal Conduit for Superior Mesenteric Vein Defect during Colon Cancer Surgery for Krukenberg Tumor: A Case Report
Authors: Raeeszadeh Mohammad , Hashemi Seyedeh Razieh , Esmailzadeh Arezoo , Maghsoudi Houshyar , Rokhgireh Samaneh , Morshedi Mahdi 
Published: July 2020

Abstract
Background: Venous resection and reconstruction are common during pancreaticoduodenectomy due to pancreatic adenocarcinoma. Multiple treatment options have been offered for venous repair. In this regard, the present study used the peritoneum as a conduit for the superior mesenteric vein (SMV) reconstruction during colon cancer surgery.Case presentation: The case was a 55-year-old woman with colon adenocarcinoma. The SMV damage was 6 cm in length. The defect was replaced with peritoneal conduit originated from parietal peritoneum of the abdominal wall. Coalition and flow of the SMV were confirmed by contrast-enhanced computed tomography. The patient had a good condition during a 6 months follow-up. Conclusions: Due to its availability and lower overall costs, peritoneal conduit might be a promising choice for SMV defects, in emergent conditions.
Efficiency Analysis of Warm Gas Clean up in Integrated Gasification Fuel Cell (IGFC) System
Authors: Hao Peixuan , Zhu Xuancan , Li Shuang , Shi Yixiang , Cai Ningsheng 
Published: July 2020

Abstract
This study investigates the energy consumption of two kinds of pre-combustion CO2 capture technologies, the conventional Selexol process and the elevated temperature pressure swing adsorption (ET-PSA) process, in an integrated gasification fuel cell (IGFC) power plant. Power plant models with and without CO2 capture are built in Aspen Plus and the simulation of ET-PSA process is realized in gPROMS. Specific primary energy consumption for CO2 avoided (SPECCA), a function related to CO2 emission rate and electric efficiency, is used to quantitatively evaluate the CO2 capture energy consumption. ET-PSA technology purifies the syngas at over 150 °C, avoiding the efficiency penalty caused by cooling and reheating processes in conventional purification methods. Adding reflux and rinse to ET-PSA procedures is proved to be effective ways to improve H2 recovery. When the CO2 capture rate is 90% and 99%, the SPECCA of ET-PSA is 1.80 and 2.72 kJ/kg, respectively, while the corresponding outcomes of Selexol is 3.46 and 3.66 kJ/kg, respectively. The reduction of energy consumption is mainly attributed to the saving of sensible heat in the syngas.
Role of Dietary Antioxidants and Vitamins Intake in Semen Quality Parameters: A Cross-sectional Study
Authors: Ghiasvand Reza , Marvast Laleh Dehghan , Nouri Mehran , Jahanbakhsh Aida , haeri farahnaz 
Published: July 2020

Abstract
Objective

Infertility had an increasing trend between couples in Iran. Several factors such as lifestyle, physical activity, unhealthy dietary habits and stress are associated with production of ROS in seminal fluid. The aim of this study was to identify the role of dietary antioxidants and vitamins intake on semen quality parameters, among Iranian infertile men.
Methods

This cross-sectional study was performed on 400 newly diagnosed infertile men in Yazd Reproductive sciences Institute from July 2019 to December 2019. The presence of infertility was confirmed by an expert andrologist, based on WHO criteria. Dietary antioxidants and vitamins intake were assessed using a 168 items semi-quantitative food frequency questionnaire (FFQ).
Results

We found an association between semen volume and Alpha Carotene dietary intake, total motility and Beta Cryptoxanthin dietary intake, and sperm count with riboflavin intake (P = 0.03).
Conclusions

We concluded that dietary intake of Alpha Carotene, Beta Cryptoxanthin, and Riboflavin are related to sperm count, semen volume and total motility in Iranian infertile men, respectively. Our data suggest that that adhering to a diet that is rich in sources of antioxidant and vitamin can have a positive effect on men’s sexual health. However, more research is needed to confirm these relations and provide the evidence needed to exert these findings into clinical practice.
Diagnostic Laboratory Tests for COVID-19 in US: Methodology and Performance
Authors: Bastola Mrigendra M. , Locatis Craig , Fontelo Paul 
Published: July 2020

Abstract
Background: COVID-19 is a global pandemic caused by a new coronavirus strain. Innovative tests have been developed to diagnose and characterize the spread of COVID-19. Only a few studies have reported the diagnostic value of currently available tests. The diagnostic performance of the tests is a major concern after the recent resurgence in COVID-19. Methods: Published papers and FDA data on the currently available tests were used for analysis. Likelihood ratios, and predictive values of tests were computed. Only FDA approved tests were included. RT-PCR performance among different specimen types were also explored.Main results: All the published reports on the COVID-19 tests reported RT-PCR as the validation tool for their results. Not all available COVID-19 tests reported their sensitivity and specificity. Among the publications which reported, the positive likelihood ratio ranged between 0.15 to 0.88 and tests had high negative likelihood ratio (0.99). Conclusion: Although most recent publications showed high positive and negative likelihood ratios and high predictive values, the publications on test accuracy and validity have limited scope primarily due to their small sample size and insufficiencies in methodology and published data. Although most lab tests reported high sensitivity and specificity, false omission and false discovery rates were found notable in several COVID-19 lab tests. These results suggest need for caution on test results’ interpretation. Practitioners also need to integrate evidence that is evolving rapidly.
Knockdown of LncRNA-UCA1 Inhibits Breast Cancer Growth in Association with METTL14/miR-375/SOX12 Axis
Authors: Zhao Chengpeng , Ling Xiaoling , Xia Yunxia , Yan Bingxue , Guan Quanlin 
Published: July 2020

Abstract
Background

Breast cancer is a malignant tumor with high incidence in females. Burgeoning studies have analyzed the relationship between long non-coding RNA (lncRNA) and breast cancer. However, the role of LncRNA UAC1 in the pathogenesis of breast cancer remains unclear.
Methods

LncRNA-UCA1 levels were detected in breast cancer tissues and cells while correlation between LncRNA-UCA1 expression and patient survival was analyzed by the Kaplan-Meier. The proliferation, invasion and apoptosis of cells were measured by CCK-8 assay, Transwell test and flow cytometry, respectively. Protein levels of apoptosis-related factors were assessed by Western blots. RIP test detected the combination of LncRNA-UCA1 and DNA methyltransferases whereas RNA pull-down test showed the interaction of DNA methyltransferases and LncRNA UCA1. Enrichment of DNA transferase of METTL14 promoter in T47D was assessed by ChIP. Interaction between miR-375 and SOX12 was confirmed via dual-luciferase reporter assay. Tumorigenesis was observed in vivo.
Results

LncRNA-UCA1 levels were increased in breast cancer and a high LncRNA-UCA1 level was a risk factor of the poor breast cancer prognosis. Silencing LncRNA-UCA1 inhibited the proliferation and invasion but promoted apoptosis of breast cancer cells. LncRNA-UCA1 recruited DNA methyltransferase to the METTL14 promoter region to inhibit METTL14 expression in breast cancer. Low METTL14 levels were associated with stronger proliferation and invasion abilities, whereas weaker proliferation and invasion abilities were related to low LncRNA-UCA1 levels. METTL14 mediated the low expression of miR-375 by m6A modification in breast cancer.
Conclusion

Depleted LncRNA-UCA1 inhibited breast cancer growth by regulating the METTL14-miR-375-SOX12 axis in vitro and in vivo.
Did Application of Digested Sewage Sludge as Soil Amendment Alter the Abundances of Antibiotic Resistance Genes and Microbial Communities in Soil and Earthworm Gut?
Authors: Li Zheng-Hao , Yuan Li , Shao Wei , Sheng Guo-Ping 
Published: July 2020

Abstract
Background

Digested sewage sludge has been widely applied as soil amendment for enhanced crop production. However, given that digested sludge is abundant with antibiotic resistance genes (ARGs) and antibiotic resistant bacteria, the impact of digested sludge amendment on the abundances of ARGs and microbial communities in soil and soil fauna (e.g., earthworms) remains largely unknown. In this study, the patterns of ARGs and microbial communities in soil and gut of earthworms after 80-days cultivation with digested sewage sludge amendment were investigated to gain insights into this impact.
Results

The results show that the digested sludge amendment increased the initial abundances of ARGs (e.g., tetA, tetQ, and sulII) in soil. However, after 80-days cultivation, the absolute abundances of target ARGs decreased by 62.3–95.4%. The reduction in ARGs absolute abundances was further enhanced by 31.4–84.7% in the presence of earthworms. In contrast, the relative abundances of some ARGs (e.g., tetA, sulI, and blaTEM−1) in the gut of earthworms increased by 41–130 folds. The microbial community structure of soil was greatly altered because of the introduction of digested sewage sludge at initial, but it recovered to its original pattern after 80-days cultivation. This could be attributed to the gradual attenuation of anaerobic microorganisms under aerobic conditions in soil. In particular, the presence of earthworms further enhanced this phenomenon. The reduction of ARGs in the amended soils was likely attributed to microbial community shift based on redundancy analysis. Several bacterial families (e.g., Saprospiraceae, Chitinophagaceae, and Rhodanobacteraceae) were significantly correlated with the target ARGs.
Conclusions

Our results reveal that the enrichment of ARGs in soil caused by digested sludge-amendment would recover to their original levels before amendment, highlighting the contribution of earthworms to reducing the ARG abundances in amended soil via shifting the microbial community. However, we also found that the amended soil could increase ARGs abundance in the earthworm gut, which may enhance the potential risk of ARGs spread via food chain. These results may provide a new sight on the control of ARGs occurrence and dissemination in sludge-amended soil ecosystem with consideration of the impact of earthworms.
Serum immunoglobulin free light chains and their association with clinical phenotypes, serology and activity in patients with IgG4-related disease: a cross-sectional study.
Authors: Martín-Nares Eduardo , Saavedra-González Vanessa , Fagundo-Sierra Reynerio , Santinelli-Núñez Blanca Estela , Romero-Maceda Teresa , Calderón-Vasquez Karla , Hernandez-Molina Gabriela 
Published: July 2020

Abstract
Introduction: The clinical utility of serum immunoglobulin free light chains (sFLC) in IgG4-related disease (IgG4-RD) is unknown. Herein we evaluated their association with clinical phenotypes, serology and activity in patients with IgG4-RD.Methods: Cross-sectional study that included 45 patients with IgG4-RD, and as controls 25 with Sjögren’s syndrome (SS) and 15 with sarcoidosis. IgG4-RD patients were classified in clinical phenotypes: pancreato-hepato-biliary, retroperitoneum/aorta, head/neck-limited and Mikulicz/systemic; as well as proliferative vs. fibrotic phenotypes. We assessed the IgG4-RD Responder Index (IgG4-RD RI) at recruitment and measured IgG1, IgG4, κ and λ sFLC serum levels by turbidometry.Results: sFLC levels were similar among IgG4-RD, SS and sarcoidosis groups. Regarding the IgG4-RD patients, the mean age was 49 years, 24 (53.3%) were men and 55.5% had activity. Eight (17.7%) belonged to pancreato-hepato-biliary, 6 (13.3%) to retroperitoneum/aorta, 14 (31.1%) to head/neck-limited, 16 (35.5%) to Mikulicz/systemic phenotypes, whereas 36 (80%) to proliferative and 9 (20%) to fibrotic phenotypes. High κ sFLC, λ sFLC and κ/λ ratio were present in 29 (64.4%), 13 (28.9%) and 13 (28.9%) patients, respectively. There were no differences in sFLC among phenotypes. κ sFLC and κ/λ ratio correlated positively with the number of involved organs and IgG4-RD RI. Patients with renal involvement had higher k sFLC and λ sFLC. The AUC for k sFLC and λ sFLC, for renal involvement was 0.78 and 0.72, respectively. Active IgG4-RD had higher levels of κ sFLC and more frequently a high κ/λ ratio. The AUC for k sFLC and k/λ ratio for predicting active IgG4-RD was 0.67 and 0.70, respectively. sFLC correlated positively with IgG1 and IgG4 levels.Conclusions: sFLC may be useful as a biomarker of disease activity as well as multiorgan and renal involvement. In particular, a high κ/λ ratio may identify patients with active disease.
Prevention of aerosol dissemination in Orthopaedics while reaming or drilling during COVID 19 pandemic - A technical note
Authors: P Yuvarajan , Paila Surya Prakash Naidu , Chalumuri Navya , Rajshekhar  , Rajan David V 
Published: July 2020

Abstract
SARS-CoV-2 / COVID 19 is the largest health emergency and a global pandemic of recent times. Orthopaedic surgery involves procedures involving routine reaming and drilling the bones that generate substantially high volumes of aerosols and microdroplets creating a huge concern among the operating surgeons, anaesthetists and the supporting staff. We aimed at reducing the amount of aerosol generation and microdroplet spread by a simple and cost-effective technique which can be very well reproducible by anyone, thereby reducing the infection/viral load.
Time course of the sensitivity and specificity of serum anti-SARS-CoV-2 IgM and IgG antibodies for the diagnosis of symptomatic COVID-19 in Japan
Authors: Nakano Yuki , Kurano Makoto , Morita Yoshifumi , Shimura Takuya , Yokoyama Rin , Qian Chungen , Xia Fuzhen , He Fan , Kishi Yoshiro , Okada Jun , Yoshikawa Naoyuki , Nagura Yutaka , Okazaki Hitoshi , Moriya Kyoji , Seto Yasuyuki , Kodama Tatsuhiko , Yatomi Yutaka 
Published: July 2020

Abstract
The accurate and prompt diagnosis of SARS-CoV-2 infection is required for the control and treatment of the coronavirus infection disease 2019 (COVID-19). In this study, we aimed to investigate the time courses of the anti-severe acute corona respiratory syndrome coronavirus 2 (SARS-CoV-2) IgM and IgG titers and to evaluate the sensitivity and specificity of such tests according to the specific day after the onset of COVID-19 among a patient population in Japan. We measured the titers of SARS-CoV-2 IgM and IgG in sera from 100 subjects, including 26 symptomatic COVID-19 patients, using chemiluminescent immunoassay (CLIA) methods utilizing magnetic beads coated with SARS-CoV-2 nucleocapsid protein and spike protein. The results of a ROC analysis suggested the possibility that the cutoff values in Japan might be lower than the manufacturer’s reported cutoff (10 AU/mL): 1 AU/mL for IgM and 5 AU/mL for IgG. The sensitivity of the test before Day 8 after symptom onset was less than 50%; at Days 9-10, however, we obtained a much higher sensitivity of 81.8% for both IgM and IgG. At 15 days or later after symptom onset, the SARS-CoV-2 IgG test had a sensitivity of 100%. These results suggest that if the number of days since disease onset is taken into consideration, these antibody tests could be very useful for the diagnosis of COVID-19 and similar diseases.
ESPERANÇA NO TRABALHO RESULTADOS DE UMA PESQUISA HOPE AT WORK RESULTS OF A RESEARCH
Authors: Costa Elaine De Souza 
Published: July 2020

Elaine de Souza Costa[1] Fernando Toledo Ferraz[2] Resumo: Este artigo é resultante de pesquisa realizada em estudos de mestrado, cujo foco principal esteve sobre a Felicidade e o Bem-Estar na Gestão do Trabalho. Partiu do pressuposto que os trabalhadores precisam encontrar uma dimensão de valor entre as atividades que realizam e os resultados que recebem de seus empregadores e gestores como resposta e espelho sobre este trabalho realizado. Através das publicações científicas consultadas, foram observados indícios de que para as pessoas alcançarem estágios de felicidade e bem-estar, passam por rotas internas de expectativas, resiliência, adaptação e esperança, que são os caminhos de aprendizado e estímulo por onde os indíviduos se movem para o atingimento de metas. A Esperança encontra-se no cerne dos caminhos levantados pela Psicologia Positiva, organizada por Martin Seligman a partir de 1998 ao tomar posse da APA (American Psychological Association). O psicólogo a partir desta data, com a contribuição de diversos pesquisadores, verificou que em todas as culturas e religiões do mundo, há um compartilhamento dos mesmos conceitos sobre as capacidades internas humanas, que foram classificadas pela Psicologia Positiva como Forças e Virtudes. Os caminhos da Esperança encontram-se dentro desses grupos de forças e virtudes estudados por esta psicologia mais recente, em sendas que levam os indivíduos a pensar e analisar as situações por todos os ângulos em busca de resolução de problemas e atingimento de metas que conduzam ao bem-estar, felicidade e qualidade de vida.Palavras-Chave: Esperança. Esperança Disposicional. Bem-Estar [1] Mestre em Sistemas de Gestão pela Universidade Federal Fluminense, UFF, Niterói/RJE-mail: elainemaebineri@gmail.com[2] Doutor em Engenharia de Produção, Professor do Departamento de Engenharia de Produção e Mestrado em Sistemas de Gestão da Universidade Federal Fluminense, UFF, RJ. E-mail: fernandoferraz@id.uff.br
El Mahragan como espacio fronterizo
Authors: García José Sánchez 
Published: July 2020

Este artículo ofrece un enfoque alternativo para analizar experiencias sociales, políticas y culturales como el Mahragan, situadas en estructuras de poder asimétricas históricamente construidas, más allá de las dicotomías epistemológicamente dominantes que contrastan entre islam y modernidad. Me propongo entonces, a partir experiencias etnográficas con grupos juveniles de la ciudad de El Cairo desde el año 1999, un ensayo antropológico-histórico que permitirá comprender, además de la propia marginalización del universo cultural shabi, las relaciones de poder establecidas en la estructura social egipcia. Estos puntos de partida hacen que el Mahragan aparezca como un encuentro histórico, una respuesta de las personas jóvenes egipcias que hunde raíces en tradiciones musicales pasadas, para transcender lo que identificamos como modernidad colonial, dentro de los contextos islámicos. A través de los análisis de la música Mahragan, analizaremos la dinámica de la dialéctica de colonización-descolonización para profundizar en la comprensión de los espacios simbólicos de la frontera como los creados en las periferias cairotas.
Prevalence of and Risk Factors for Low Free Testosterone Levels in Japanese Men with Well-controlled Human Immunodeficiency Virus Infection
Authors: Yoshino Yusuke , Koga Ichiro , Wakabayashi Yoshitaka , Kitazawa Takatoshi , Ota Yasuo 
Published: July 2020

Background:
The change in the prevalence of hypogonadism with age in men with human
immunodeficiency virus (HIV) infection is subject to debate.

Objective:
To address this issue, we diagnosed hypogonadism based on serum levels of free testosterone
(fTST) rather than total testosterone which is thought to be an inaccurate indicator. We also
determined the relationship between age and fTST levels and identified risk factors for hypogonadism
in men with HIV infection.

Method:
We retrospectively reviewed fTST levels and associated clinical factors in 71 wellcontrolled
HIV-infected men who were treated at Teikyo University Hospital between April 2015
and March 2016 and who had data available on serum fTST levels, measured >6 months after starting
antiretroviral therapy. fTST was measured using radioimmunoassay on blood samples collected
in the morning. Risk factors for hypogonadism were identified using Welch’s t-test and multiple regression
analysis.

Results:
The men had a mean (± standard deviation) age of 47.4 ± 13.6 years, and mean (± standard
deviation) serum fTST level of 13.0 ± 6.1 pg/mL. Fifteen (21.1%) men had hypogonadism based on
a fTST <8.5 pg/mL. Serum fTST levels significantly decreased with age (−0.216 pg/mL/year).
Older age and low hemoglobin levels were identified as risk factors for hypogonadism.

Conclusion:
The men in the study experienced a more rapid decline in fTST levels with age than
men in the general population (−0.161 pg/mL/year). Serum fTST levels in men with HIV infection
should be monitored, especially in older men and those with low hemoglobin levels.
A New Precursor for the Radiosynthesis of 6-O-(2-[18F]Fluoroethyl)-6-Odesmethyl- diprenorphine ([18F]FE-DPN) by Nucleophilic Radiofluorination
Authors: Marton János , Cumming Paul , Bauer Beate , Henriksen Gjermund 
Published: July 2020

:
We present the preparation of the new precursor 6-O-(2-tosyloxyethoxy)-6-O-desmethyl-3-
O-trityl-diprenorphine (TE-TDDPN) for a one-pot, two-step nucleophilic radiosynthesis of 6-O-(2-
[18F]fluoroethyl-6-O-desmethyl-diprenorphine ([18F]FE-DPN). The route to the precursor consists of a
five-step synthesis starting from diprenorphine. We also provide alternative synthesis routes for the
cold reference standard and the complete 1H- and 13C-NMR assignment of the prepared derivatives.