bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postprandial zinc stable isotope response in human blood serum
Authors: Sullivan Kaj , Moore Rebekah E T , Rehkämper Mark , Layton-Matthews Daniel , Leybourne Matthew I , Puxty John , Kyser T Kurt 
Published: June 2020

Abstract
In recent years, considerable advances have been made in the field of medical isotope metallomics, but numerous fundamental physiological processes remain to be investigated. Past studies report that blood serum Zn concentrations decrease by between about 10 and 25%, depending on the size of meal, approximately three hours postprandially (i.e. after eating), before returning to baseline values if no meals are consumed over the following four to five hours. Nine participants were recruited for this study to investigate whether this postprandial Zn concentration decrease is accompanied by a stable isotope response. A baseline serum sample was collected from participants in the morning after overnight fasting. A 576 kcal meal was then provided and additional serum samples were taken 90 and 180 minutes post-meal to coincide with the postprandial response. Serum Zn concentrations decreased postprandially by an average of 21 ± 9% (1SD), but this was not accompanied by a change in stable Zn isotope composition (mean Δ66Zn180-minute-baseline = 0.01 ± 0.09‰, 2SD). We propose that hemodilution and the rapid, efficient postprandial transfer of albumin-bound Zn from serum to the liver and pancreas is responsible for the lack of postprandial serum Zn isotopic response. These results indicate that studies examining solely the distribution of Zn isotopes in serum may obtain samples without considering timing of the most recent meal. However, future studies seeking to compare serum Zn concentrations with δ66Zn values should draw blood samples in the morning after overnight fasting.
Comprehensive analysis of the effect of rs2295080 and rs2536 polymorphisms within the mTOR gene on cancer risk
Authors: Qi Guang-Hui , Wang Chun-Hui , Zhang Hong-Ge , Yu Jian-Guo , Ding Fei , Song Zhi-Chao , Xia Qing-Hua 
Published: June 2020

Abstract
There is still no conclusion on the potential effect of the rs2295080 and rs2536 polymorphisms of mTOR (mammalian target of rapamycin) gene on different cancers. Herein, we performed a comprehensive assessment using pooled analysis, FPRP (false-positive report probability), TSA (trial sequential analysis), and eQTL (expression quantitative trait loci) analysis. Eighteen high-quality articles from China were enrolled. The pooled analysis of rs2295080 with 9502 cases and 10,965 controls showed a decreased risk of urinary system tumors and specific prostate cancers [TG vs. TT, TG+GG vs. TT and G vs. T; P&lt;0.05, OR (odds ratio) &lt;1]. FPRP and TSA data further confirmed these results. There was an increased risk of leukemia [G vs. T, GG vs. TT, and GG vs. TT+TG genotypes; P&lt;0.05, OR&gt;1]. The eQTL data showed a potential correlation between the rs2295080 and mTOR expression in whole blood samples. Nevertheless, FPRP and TSA data suggested that more evidence is required to confirm the potential role of rs2295080 in leukemia risk. The pooled analysis of rs2536 (6653 cases and 7025 controls) showed a significant association in the subgroup of “population-based” control source via the allele, heterozygote, dominant, and carrier comparisons (P&lt;0.05, OR&gt;1). In conclusion, the TG genotype of mTOR rs2295080 may be linked to reduced susceptibility to urinary system tumors or specific prostate cancers in Chinese patients. The currently data do not strongly support a role of rs2295080 in leukemia susceptibility. Large sample sizes are needed to confirm the potential role of rs2536 in more types of cancer.
Elevated expression of minichromosome maintenance 3 indicates poor outcomes and promotes G1/S cell cycle progression, proliferation, migration and invasion in colorectal cancer
Authors: Zhou He , Xiong Yongfu , Zhang Guangjun , Liu Zuoliang , Li Lifa , Hou Songlin , Zhou Tong 
Published: June 2020

Abstract
Background: The minichromosome maintenance (MCM) family, a core component of DNA replication, is involved in cell cycle process. Abnormal proliferation has been identified as a crucial process in the evolution of colorectal cancer (CRC). However, the roles of the MCM family in CRC remain largely unknown.
Methods: Here, the expression, prognostic significance and functions of the MCM family in CRC were systematically analyzed through a series of online databases including CCLE, Oncomine, HPA, cBioPortal and cancerSEA.
Results: We found all MCM family members were highly expressed in CRC, but only elevation of MCM3 expression was associated with poor prognosis of patients with CRC. Further in vitro and in vivo experiments were performed to examine the role of MCM3 in CRC. Analysis of CCLE database and qRT-PCR assay confirmed that MCM3 was overexpressed in CRC cell lines. Moreover, knockdown of MCM3 significantly suppressed transition of G1 to S phase in CRC cells. Furthermore, down-regulation of MCM3 inhibited CRC cell proliferation, migration, invasion and promoted apoptosis.
Conclusion: These findings reveal that MCM3 may function as an oncogene and a potential prognosis biomarker. Thus, the association between abnormal expression of MCM3 and the initiation of CRC deserves further exploration.
Recovery and Relapse: Perspectives From Adults Who Stutter
Authors: Tichenor Seth E. , Yaruss J. Scott 
Published: June 2020

PurposeRecovery and relapse relating to stuttering are often defined in terms of the presence or absence of certain types of speech disfluencies as observed by clinicians and researchers. However, it is well documented that the experience of the overall stuttering condition involves more than just the production of stuttered speech disfluencies. This study sought to identify what recovery and relapse mean to people who stutter based on their own unique experiences to account for both the stuttering behaviors and the broader adverse impact of the condition.MethodIn this study, 228 adults who stutter participated in a mixed-methods exploration of the terms “recovery” and “relapse.” Participants categorized themselves on whether they considered themselves to have recovered or experienced relapse. Data were analyzed thematically through the lens of the speaker self-categorizations to determine how adults who stutter define recovery and relapse regarding stuttering.ResultsResults indicate that, to adults who stutter, recovery from stuttering is associated with increases in positive affective/emotional, behavioral, and cognitive reactions to the condition and simultaneous decreases in associated negative constructs. These group-level definitions did not change as a function of whether respondents reported that they had experienced recovery or relapse themselves.DiscussionRecovery or relapse from stuttering behaviors can occur independently from recovery or relapse from the broader adverse impact related to the condition, suggesting that researchers and clinicians should consider recovery and relapse as involving more than just a reduction or an increase in observable behaviors. These findings support recent research evidence further specifying the many individual phenotypes of stuttering, in that pathways to recovery and relapse can be experienced in different ways for people with different stuttering phenotype profiles.
Radio and X-ray connection in radio mini-halos: Implications for hadronic models
Authors: Ignesti A. , Brunetti G. , Gitti M. , Giacintucci S. 
Published: June 2020

Context. A large fraction of cool-core clusters are known to host diffuse, steep-spectrum radio sources, called radio mini-halos, in their cores. Mini-halos reveal the presence of relativistic particles on scales of hundreds of kiloparsecs, beyond the scales directly influenced by the central active galactic nucleus (AGN), but the nature of the mechanism that produces such a population of radio-emitting, relativistic electrons is still debated. It is also unclear to what extent the AGN plays a role in the formation of mini-halos by providing the seeds of the relativistic population.
Aims. In this work we explore the connection between thermal and non-thermal components of the intra-cluster medium in a sample of radio mini-halos and we study the implications within the framework of a hadronic model for the origin of the emitting electrons.
Methods. For the first time, we studied the thermal and non-thermal connection by carrying out a point-to-point comparison of the radio and the X-ray surface brightness in a sample of radio mini-halos. We extended the method generally applied to giant radio halos by considering the effects of a grid randomly generated through a Monte Carlo chain. Then we used the radio and X-ray correlation to constrain the physical parameters of a hadronic model and we compared the model predictions with current observations.
Results. Contrary to what is generally reported in the literature for giant radio halos, we find that the mini-halos in our sample have super-linear scaling between radio and X-rays, which suggests a peaked distribution of relativistic electrons and magnetic field. We explore the consequences of our findings on models of mini-halos. We use the four mini-halos in the sample that have a roundish brightness distribution to constrain model parameters in the case of a hadronic origin of the mini-halos. Specifically, we focus on a model where cosmic rays are injected by the central AGN and they generate secondaries in the intra-cluster medium, and we assume that the role of turbulent re-acceleration is negligible. This simple model allows us to constrain the AGN cosmic ray luminosity in the range ∼1044−46 erg s−1 and the central magnetic field in the range 10–40 μG. The resulting γ-ray fluxes calculated assuming these model parameters do not violate the upper limits on γ-ray diffuse emission set by the Fermi-LAT telescope. Further studies are now required to explore the consistency of these large magnetic fields with Faraday rotation studies and to study the interplay between the secondary electrons and the intra-cluster medium turbulence.
Neural network reconstruction of the dense matter equation of state derived from the parameters of neutron stars
Authors: Morawski F. , Bejger M. 
Published: June 2020

Context. Neutron stars are currently studied with an rising number of electromagnetic and gravitational-wave observations, which will ultimately allow us to constrain the dense matter equation of state and understand the physical processes at work within these compact objects. Neutron star global parameters, such as the mass and radius, can be used to obtain the equation of state by directly inverting the Tolman-Oppenheimer-Volkoff equations. Here, we investigate an alternative approach to this procedure.
Aims. The aim of this work is to study the application of the artificial neural networks guided by the autoencoder architecture as a method for precisely reconstructing the neutron star equation of state, using their observable parameters: masses, radii, and tidal deformabilities. In addition, we study how well the neutron star radius can be reconstructed using only the gravitational-wave observations of tidal deformability, that is, using quantities that are not related in any straightforward way.
Methods. The application of an artificial neural network in the equation-of-state reconstruction exploits the non-linear potential of this machine learning model. Since each neuron in the network is basically a non-linear function, it is possible to create a complex mapping between the input sets of observations and the output equation-of-state table. Within the supervised training paradigm, we construct a few hidden-layer deep neural networks on a generated data set, consisting of a realistic equation of state for the neutron star crust connected with a piecewise relativistic polytropes dense core, with its parameters representative of state-of-the art realistic equations of state.
Results. We demonstrate the performance of our machine-learning implementation with respect to the simulated cases with a varying number of observations and measurement uncertainties. Furthermore, we study the impact of the neutron star mass distributions on the results. Finally, we test the reconstruction of the equation of state trained on parametric polytropic training set using the simulated mass–radius and mass–tidal-deformability sequences based on realistic equations of state. Neural networks trained with a limited data set are capable of generalising the mapping between global parameters and equation-of-state input tables for realistic models.
Meta-analysis: Resistance Training Improves Cognition in Mild Cognitive Impairment
Authors: Zhang Lulu , Li Bin , Yang Jingjing , Wang Fengling , Tang Qianyun , Wang Shuhong 
Published: June 2020

AbstractThis study investigated the benefits of resistance training on cognition in patients with mild cognitive impairment. We searched the PubMed, Embase and Cochrane Library databases, and seven randomized controlled trials were reviewed. We evaluated the risk of bias using the Cochrane Collaboration’s bias assessment tool. Standard mean differences with 95% confidence intervals were calculated for statistical analysis. This meta-analysis assessed three variables: general cognitive function, executive function and working memory. The results indicate that general cognitive function improved significantly (standardized mean difference: 0.53, P=0.04), and further subgroup analyses on frequency and duration per session showed that the subgroups ‘twice a week’ (P=0.01) and ‘duration per session >60 min’ (P=0.0006) exhibited better performance than the subgroups ‘three time a week’ (P=0.47) and ‘duration per session <60 min’ (P=0.53). Additionally, a moderate effect size was found in executive function (standardized mean difference: 0.50, P=0.0003), and there was non-significant effect in working memory (P=0.14). In summary, resistance training may mitigate mild cognitive impairment by improving cognition. Larger-scale studies are recommended to demonstrate the relationship between resistance training and cognition in mild cognitive impairment.
Hemostatic Modification of the Bentall Procedure Using an Overlap Suture Technique
Authors: Kasai Mio , Yoshitake Akihiro , Shimizu Hideyuki 
Published: June 2020

AbstractBleeding from the proximal suture line after replacement of the aortic root can be very difficult to control. Such bleeding is an important predictor of morbidity and mortality. Here, we detail a reliable method that is simple to perform and effectively prevents surgical bleeding. We adopted a technique of overlapping the pledgeted interrupted U-stitches of the proximal sutures on the prosthetic graft, which can eliminate the bleeding from the proximal suture line.
Abdominal Aortic Occlusion by Hydatid Cysts
Authors: Debi Uma , Bhatia Vikas , Sandhu M.S. 
Published: June 2020

AbstractHydatid disease is a parasitic infestation caused by the larval stage of Echinococcus. It can infest any part of the body; however, aortic hydatid disease is rare. Involvement of the abdominal aorta is usually due to embolization from cardiac hydatid cysts or direct invasion and can be present at intravascular or intramural locations. Aortic hydatid disease may present with fatal complications, such as anaphylaxis, pseudoaneurysm formation, systemic embolism, and arterial occlusion.
TO COMPARE AND EVALUATE THE EFFICACY OF BIFLUORID 12, DIODE LASER AND THEIR COMBINED EFFECT IN TREATMENT OF DENTINAL HYPERSENSITIVITY - A CLINICAL STUDY
Authors: Tailor Ankur , Shenoy Nina , Thomas Biju 
Published: June 2020

Abstract:
Background: To evaluate the immediate efficacy in the reduction of dentine hypersensitivity (DH) when applying an 808±10 nm diode laser (DL) with topical Bifluorid 12® (6%NaF and 6%CaF).
Materials and Methods: The study was conducted on 90 teeth with DH assessed by tactile and cold air stimuli measured by Numeric Rating Scale(NRS). Teeth were randomly divided into G1(30 teeth) treated by Bifluorid 12®; G2(30 teeth) lased at 0.5 W with continuous, noncontact mode with 400μ fibre. Each tooth received one application; G3(30 teeth) received Bifluorid 12® plus laser at same G2 th parameters. NRS was checked before starting the treatment and 15 to 30 mins after irradiating and on the 7 day.
Results: Significant pain reduction was seen. The NRS reduction percentages were calculated, and there was a significant decrease of DH in G3 than G2 and G1.
Conclusion: Diode laser is a useful device for DH treatment if used alone and in combination with Bifluorid 12®
Incels, in-groups, and ideologies
Authors: Heritage Frazer , Koller Veronika 
Published: June 2020

Abstract
We present a study of the online forum Reddit, specifically a sub-forum for (typically heterosexual) men who identify as
involuntary celibates or incels. Incels are an online imagined community/community of practice who wish
to, but do not, have sexual relations with women. Owing to this identity, they view themselves as non-normative within broader society and
see women and societal standards of masculinity as the cause of their problems. In this paper, we take a small corpus of 67,000 words
generated from 50 threads created, and commented on, by incels. We analyse keywords, word frequencies, and concordance lines to explore the
representation of gendered social actors. Keyword analysis reveals that references to gendered social actors are particularly salient within
this community, leading to an analysis of all such social actors in the corpus. The findings suggest that incels position different groups
of men in a hierarchy in which conventionally attractive men occupy the top position. Notably, we find that female social actors are not
placed in a similar hierarchy. An additional appraisal analysis of the most frequently occurring male and female social actors shows that
men are judged as incapacitated while women are seen as immoral, dishonest and capable of hurting men. Members of the online community also
seem preoccupied with physical attractiveness. The study opens up a number of avenues for future research, especially into the complexities
with which members of non-normative heterosexual groups simultaneously orient to and reject social norms.
“Thaz how u kno ur dum”
Authors: Chambers Eric 
Published: June 2020

Abstract
This study analyzes language use among a group of gay men who participate on an online messageboard (OnYourKnees), focused
on the attainment of a ‘dumb jock’ identity. Posters align with a series of qualities that largely conform to ideologies of American jock
masculinity, but at the same time satirize those ideologies: in particular, many posters view as an integral quality of dumb-jock identity
‘dumbness:’ an unwillingness/inability to engage in scholarly/academic pursuits. The repeated citationality of dumbness as a positive
quality creates a distinct identity-type that posters link with erotic desire. Orthographic variation contributes to the attainment and
recognition of a jock identity: posters who identify as jocks are more likely to display non-standard American English spelling than those
who do not. This study thus highlights the importance of orthographic variation in maintaining distinct identities among local communities,
especially in a space where traditional ideologies of masculinity are recontextualized.
Activewear and other vaguery
Authors: Cohen Dana 
Published: June 2020

Abstract
In the literature on the mass-count distinction,
some nominals that denote groupings of objects (e.g. English
furniture) are known to display hybrid properties,
exhibiting syntactic distribution akin to prototypical non-count nominals
(substance-denoting, e.g. mud), but showing certain
semantic properties associated with plurals. This paper aims to broaden our
perspective on the properties of such nouns, focusing on their morphological
composition in three languages, English, French, and Hebrew, where nouns of this type are
frequently created through specific derivational processes. This systematic
derivation suggests that the combination of properties associated with these
nouns should not be seen as an idiosyncratic exception to the mass-count
distinction, but as a systematic category between the two.
Countability and grammatical number
Authors: Ojeda Almerindo E. 
Published: June 2020

Abstract
The purpose of this paper is to define number categories as government classes, and to interpret said categories semantically against models which are rich enough to support the desired interpretations. Defining number categories as government classes in terms of their cooccurrence with numerals leads to a system of five pairs of binary categories in complementary opposition: SINGULAR/COSINGULAR, DUAL/CODUAL, PAUCAL/COPAUCAL, MESAL/COMESAL, and UNIVERSAL/COUNIVERSAL. To support the interpretation of these ten categories we focus on Boolean models and compare those that split dualistically into atomistic and atomless portions with those that are uniformly atomless instead. After arguing that models for the interpertation of number should be uniformly atomless, we show how these models can support the interpretation of all count nouns regardless of number category. Particularly their cooccurrence with numerals. Key to such interpretations will be the ability to refer to atomistic structures embedded deeply within atomless models.
Comparatives in Brazilian Portuguese
Authors: Rothstein Susan , Pires De Oliveira Roberta 
Published: June 2020

Abstract
Comparatives in Brazilian Portuguese show that Bale and Barner’s (2009)
generalizations do not hold cross-linguistically; this leads to
reconsidering the role of cardinality in mass and count syntax. The paper
discusses contrasts in the use of naturally atomic, or object, mass nouns in
Brazilian Portuguese and English. Brazilian Portuguese has a productive bare
singular, which is analysed, following Pires de Oliveira and Rothstein (2011) as an object mass noun
with a count counterpart. However, in comparative constructions it does not
behave as Bale and Barner predict. We give an account of the relation
between counting and measuring which explains the data and we show, using
data from Hungarian, that the contrasts with English are not unique to
Brazilian Portuguese.
Countability shifts and abstract nouns
Authors: Zamparelli Roberto 
Published: June 2020

Abstract
The paper examines the mass-count distinction in abstract nouns, starting
from the corpus-derived observation that most of the nouns that can be used
in count or mass syntactic contexts (“elastic nouns”) are (arguably)
abstract. The paper evaluates various tests for mass-count status and
different criteria for “abstractness”, proposing seven semi-productive
meaning shifts that can result in a transition from mass to count or
vice-versa. Section 4.2
addresses the relation between abstract nouns and kinds (are bare abstract
terms “names of kinds”? What are their instances? Are they always kinds, even
as predicates? What types of meaning shifts are applicable to them?). The
possibility of a degree argument is also discussed: some count quantifiers
over abstract mass nouns range over degrees, but not all abstract nouns have
this option. We use the Bochum Countability Lexicon to detect elastic nouns
and classify them via morphological affixes, identifying some possible
meaning alternations.