bluuebunny/crossref_metadata_2025_split huggingface dataset:
The novel H10N3 avian influenza virus acquired airborne transmission among chickens: an increasing threat to public health
Authors: Wang Xiaoquan , Yu Huiyan , Ma Yahao , Zhang Pinghu , Wang Xiyue , Liang Jianyu , Zhang Xiuling , Gao Ruyi , Lu Xiaolong , Yang Wenhao , Chen Yu , Gu Min , Hu Jiao , Liu Xiaowen , Hu Shunlin , Peng Daxin , Qi Xian , Bao Changjun , Liu Kaituo , Liu Xiufan 
Published: December 2024

ABSTRACT

Following two human infections with the H10N3 avian influenza virus (AIV) in 2021 and 2022, a third case was discovered in Yunnan, China, in 2024, raising concerns about the potential for future pandemics. Recent studies have indicated that novel H10N3 viruses are highly pathogenic in mice and can be transmitted between guinea pigs via respiratory droplets without prior adaptation. However, the biological characteristics of novel H10N3 in poultry have not been fully elucidated. Our findings revealed that H10 subtype AIVs are predominantly prevalent in waterfowl. Notably, H10N8 and H10N3 viruses that have infected humans were primarily isolated from chickens. For the first time, double basic hemagglutinin cleavage sites (motif PEIKQGR↓GL) were identified in novel H10N3 AIVs, which exhibit enhanced replication in chickens, and can be transmitted between chickens through direct contact and respiratory droplets. Animal experimental studies demonstrated that ducks are also susceptible to H10N3 viruses and that the virus is transmissible through direct contact, suggesting a greater risk of transmission and recombination. Serological studies conducted among poultry workers suggest that while the human population was largely naïve to H10N3 infection, sporadic and undetected human infections did occur, indicating a potential increasing trend. These data further emphasize the growing threat to public health posed by zoonotic H10N3 subtype AIVs.

IMPORTANCE
Exposure to poultry in live poultry markets (LPMs) is strongly associated with human infection with avian influenza viruses (AIVs), with chickens being the most common species found in these markets in China. The prevalence of AIVs in chickens, therefore, increases the risk of human infection. Notably, the main host of the novel H10N3 virus has shifted from waterfowl to chickens, and the virus can be transmitted between chickens via respiratory droplets, posing a potential risk of a pandemic within poultry populations. The novel H10N3 virus also remains sensitive to ducks and can be transmitted through direct contact, which means a greater risk of transmission and recombination. Significantly, the human population remains largely naïve to H10N3 infection, but sporadic seropositivity among poultry workers indicates previous exposure to H10 subtype AIVs. Therefore, a comprehensive surveillance of the novel H10N3 viruses in poultry is imperative. Effective control of the virus within poultry populations could significantly reduce the risk of emerging human infections.
Effect of high-efficiency particulate air filter on children with asthma: a systematic review protocol of RCTs
Authors: Mansoor Javeria , Zia Ul Haq Muhammad , Ahsan Zeeshan , Bilal Muhammad , Fatima Syeda Sadia 
Published: December 2024

IntroductionAsthma has been classified as a major non-communicable disease by the WHO. With the worsening air quality index worldwide, the burden of asthma has increased specifically in children. The focus of the management strategy of asthma has shifted from traditional pharmacological treatments towards non-pharmacological preventive and control therapy in recent decades. The use of high-efficiency particulate air (HEPA) filters is one of the methods to achieve that, despite extensive research, the efficacy of HEPA filters in this context of effectiveness and usage guidelines remains unclear. Our study aims to examine the effect of HEPA filters in (1) reducing clinical visits or hospital admissions or the number of exacerbation events, (2) reducing asthma symptoms, (3) increasing asthma symptom-free days, (4) reducing indoor particulate matter 2.5 levels for children with asthma aged 5–17 years and (5) improving quality of life.MethodsWe will conduct a systematic review using MEDLINE, Google Scholar and Scopus as databases, article selection is planned to be restricted to randomised controlled trials only (2002–2025). We are following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines developed specifically for the protocol(s). Two reviewers will screen the studies independently and assess study quality using the Cochrane Risk of Bias Tool for Randomised Trials, V.2. The results of outcome measure(s) will be summarised in tables. If the studies are sufficient, we will also perform a quantitative analysis by creating forest plots and subgroup analysis will be performed if required. Lastly, publication bias will be assessed using a funnel plot and Egger’s test and reported accordingly.Ethics and disseminationWe will conduct a systematic review, therefore there is no need for a formal ethical review. After successful completion, our results will be published in a peer-reviewed journal.PROSPERO registration numberCR42024494949.
Participatory longitudinal qualitative interview study to understand Autistic gynaecological and obstetric health: the Autism from menstruation to menopause study protocol
Authors: Grant Aimee , Williams Gemma L , Axbey Harriet , Wilkins Abigail , Firth Ellen , Lim Hazel , Cave Helen , Williams Kathryn , Ribbons Kay , Sinfield Madeleine , Craine Monique , Caemawr Selena , Holloway Willow , Brown Amy , Nicolaidis Christina , Kara Helen , Ellis Rebecca 
Published: December 2024

IntroductionAutism is a lifelong minority neurotype present from birth. There is a dearth of credible evidence to suggest gender variation in Autism prevalence, despite historical under-diagnosis of women. Autistic people Assigned Female At Birth (AFAB) have worse physical and mental health compared with non-Autistic peers. To date, the reproductive health experiences of Autistic AFAB people have been under-investigated.Methods and analysisThis study aims to co-develop a quality improvement intervention to improve the reproductive health of Autistic people. The study uses Community Partnered Participatory Research (an approach similar to Community-Based Participatory Research), largely through a Community Council that co-governs the study. To understand reproductive health needs, a longitudinal qualitative investigation using creative methods will be undertaken with 100 Autistic AFAB people with 10 waves of data collection over 5 years (interview n=500–1000). Participants will be purposively selected to include harder-to-reach members of the Autistic community, including those who are non-speaking or semi-speaking, have a learning disability and those from marginalised ethnicities. Data will be analysed thematically with Community Council involvement. Intervention development will be undertaken from 2029 onwards.Ethics and disseminationWe are an Autistic-led team that adopts a social model of disability. However, this study raises ethical issues relating to sensitive topics and marginalised populations. Accordingly, we have robust procedures in place to assess capacity to ensure informed consent and to allow participants to take part without opting into data sharing. Ethical approval has been awarded by the Swansea University School of Health and Social Care Research Ethics Committee. We will publish our findings as open access articles in peer-reviewed journals.
Incidence of pressure injury in patients with moderate and severe traumatic brain injury: a systematic review
Authors: Ribeiro Ranya Nascimento , Oliveira Daniel Vieira de , Paiva Wellingson S , Sousa Regina Marcia C , Vieira Rita de Cassia A 
Published: December 2024

BackgroundPatients with moderate and severe traumatic brain injury (TBI) admitted to the intensive care unit (ICU) may develop pressure injury (PI) due to haemodynamic instability caused by the disease, lack of mobility in bed, as well as intense and prolonged compression in prominent bone areas.ObjectiveThe objective of this review is to assess the incidence and identify risk factor for the development of PI in patients with moderate and severe TBI admitted to the ICU.MethodSearches were conducted in the PubMed, CINAHL, Scopus, Embase, Web of Science, Google Scholar, Trove and Open Grey databases, including all records found up to May 2023. Patients with moderate and severe TBI admitted to the ICU were included in this review.ResultsA total of 368 studies on PI and TBI were identified in the databases. Two authors assessed study bias and extracted data, wit. h a third reviewer as arbitrator. Six studies met the inclusion and exclusion criteria in the review. The incidence of PI varied between 6.5% and 20% among the included studies. Only two studies applied the Braden Scale, which identified stage II lesions (52.6% and 51.5%), located in the sacral region (78.9% and 54.6%). The risk factors identified in the studies for the development of PI were mechanical ventilation, TBI severity, vasoactive drugs, age, fever, use of enteral nutrition, haemoglobin levels and time to perform tracheostomy.ConclusionThe incidence of PI in moderate and severe patients was similar to that found in ICU patients. There were significant differences across the various studies in the ways in which data were collected and reported.Trial registration numberThe protocol has been deposited in the PROSPERO repository (CRD42023428817).
JPEG Column: 99th JPEG Meeting
Authors: Pinheiro Antonio 
Published: December 2024

The 99th JPEG meeting was held online, from 24th to 28th April 2023.
Providing tools suitable for establishing provenance, authenticity and ownership of multimedia content is one of the most difficult challenges faced nowadays, considering the technological models that allow effective multimedia data manipulation and generation. As in the past, the JPEG Committee is again answering the emerging challenges in multimedia. JPEG Trust is a standard offering solutions to media authenticity, provenance and ownership.
All-trans Retinoic Acid Sensitizes Epithelial Ovarian Cancer to PARP Inhibition after Exposure to Cisplatin
Authors: Mei Bingjie , Li Junyang , Wang Dengfeng , Feng Lu , Huang Jianming , Zhang Guonan 
Published: December 2024

Abstract
Epithelial ovarian cancer (EOC) is the most lethal of gynecologic malignancies. The standard-of-care treatment for EOC is platinum-based chemotherapy such as cisplatin (CDDP). Notably, platinum-based chemotherapy induces resistance of EOC to PARP inhibition. However, therapeutic approaches targeting PARP inhibitor (PARPi) resistance remain to be explored. In this study, we show that all-trans retinoic acid (ATRA) reduces PARPi resistance–associated EOC cells induced by CDDP treatment. Clinically applicable ATRA suppressed the outgrowth of CDDP-treated EOC cells both in vitro and in vivo. Moreover, a CDDP treatment followed by niraparib maintenance therapy in combination with ATRA improved the survival of EOC-bearing mice. These phenotypes correlated with the PARPi-resistant EOC signature, which consists of elevated expression of aldehyde dehydrogenase 1 family member A1, nicotinamide phosphoribosyltransferase, PARP1, and checkpoint kinase 1, as well as elevated NAD+ level–mediated high activity of aldehyde dehydrogenase 1 family member A1 and PARP1. Mechanistically, ATRA downregulates the expression of these genes and level of intracellular NAD+. Our results suggest that ATRA in conjunction with PARPi represents a promising maintenance therapeutic strategy for EOC.
ET-3/ETBR Mediates Na
+
-Activated Immune Signaling and Kidney Lymphatic Dynamics
Authors: Mutchler Ashley L. , Zhong Jianyong , Yang Hai-Chun , Zhao Shilin , Crescenzi Rachelle , Taylor Shannon , Rao Roy L. , Shelton Elaine L. , Kirabo Annet , Kon Valentina 
Published: December 2024

BACKGROUND:
Lymphatic collecting vessels in the kidney are critical in clearing interstitial fluid, macromolecules, and infiltrating immune cells. Dysfunction of the lymphatic vessels can disrupt this process and exacerbate injury-associated inflammation in many disease conditions. We previously found that sodium accumulates within the kidney interstitium during proteinuric kidney injury and elevated sodium environments stimulate isolevuglandin production in antigen-presenting cells, stimulating T cells, and modulating inflammatory responses. In the present study, we investigated whether proteinuric injury increases production of isolevuglandin-adduct formation in antigen-presenting cells, their effects on lymphatic endothelial cells (LECs), and the role of the ET-3 (endothelin-3)/ETBR (endothelin type B receptor) on lymphatic vessel function.

METHODS:
We used a mouse model of nephrotoxin-induced proteinuric injury to show that proteinuric injury expanded the kidney lymphatic network and to immunophenotype the infiltrating immune cells. To determine mechanisms, we analyzed the interaction of migratory immune cells and LECs using an in vitro transwell migration assay, bulk RNA sequencing, and flow cytometric analysis. To determine the effect of ET-3/ETBR axis on lymphatic vessel contractility, we analyzed microdissected lymphangions utilizing a vessel perfusion chamber.

RESULTS:
We found that animals with proteinuric injury have increased kidney lymphangiogenesis, isolevuglandin-producing dendritic cells, and IFN (interferon)-γ–producing CD4+T cells. The sodium avid environment present in kidney injury enhances the interaction between LECs and migratory antigen-presenting cells and LEC production of isolevuglandin-adducts. Elevated sodium environment-induced isolevuglandin-adduct formation facilitates the ET-3/ETBR communication between LECs and dendritic cells. In addition, the ET-3/ETBR axis modulates lymphatic collecting vessel pumping dynamics.

CONCLUSIONS:
These findings reveal a novel mechanism linking the isolevuglandin-mediated ET-3/ETBR axis with LECs and infiltrating dendritic cells. ET-3/ETBR signaling in lymphatic vessel dynamics is a novel pathogenic component and a possible therapeutic target in kidney disease.
Differential weighting of information during aloud and silent reading: Evidence from representational similarity analysis of fMRI data
Authors: Bailey Lyam M. , Matheson Heath E. , Fawcett Jonathon M. , Bodner Glen E. , Newman Aaron J. 
Published: December 2024

Abstract
Single-word reading depends on multiple types of information processing: readers must process low-level visual properties of the stimulus, form orthographic and phonological representations of the word, and retrieve semantic content from memory. Reading aloud introduces an additional type of processing wherein readers must execute an appropriate sequence of articulatory movements necessary to produce the word. To date, cognitive and neural differences between aloud and silent reading have mainly been ascribed to articulatory processes. However, it remains unclear whether articulatory information is used to discriminate unique words, at the neural level, during aloud reading. Moreover, very little work has investigated how other types of information processing might differ between the two tasks. The current work used representational similarity analysis (RSA) to interrogate fMRI data collected while participants read single words aloud or silently. RSA was implemented using a whole-brain searchlight procedure to characterise correspondence between neural data and each of five models representing a discrete type of information. Both conditions elicited decodability of visual, orthographic, phonological, and articulatory information, though to different degrees. Compared with reading silently, reading aloud elicited greater decodability of visual, phonological, and articulatory information. By contrast, silent reading elicited greater decodability of orthographic information in right anterior temporal lobe. These results support an adaptive view of reading whereby information is weighted according to its task relevance, in a manner that best suits the reader’s goals.
Monuments to the “Memorable Gale”: Art and Hurricane Memory in Nineteenth-Century New England
Authors: Barrett Ross 
Published: December 2024

Abstract
Reconstructing the controversy that arose around a proposed memorial to the Great September Gale—a Category 4 hurricane that battered Providence, Rhode Island in 1815—this essay explores the differing ways that public leaders and everyday citizens remembered the tropical storms that hit New England in the nineteenth century.
Low-velocity impact resistance and failure characteristics of all thermoplastic woven polymer-fiber-reinforced plastic composites
Authors: Ko Seunghyun , Qiao Yao , Roosendaal Timothy J , Denny Adam C , Ramos Jose L , Shahwan Khaled W , Simmons Kevin L 
Published: December 2024

This study addresses the impact performances of recyclable composites made of all thermoplastic polymer-fiber-reinforced plastics (PFRPs), where the reinforcing fibers and matrix are made of thermoplastic polymers. Three woven PFRPs systems were evaluated, including polypropylene fibers, polypropylene matrix, and high-density polyethylene matrix. In low-velocity impact scenario with an impactor speed of less than 6 m/s, our results demonstrate the energy absorption capabilities of the flat laminate PFRPs compared to woven carbon fiber-reinforced plastics (CFRPs) and aluminum alloy 5052. For the systems studied, the PFRPs can reach the specific energy absorption 89% to 115% of the CFRPs. Even compared with the aluminum alloy 5052, the PFRPs can reach up to 97%. We investigate the failure morphologies of the PFRPs using X-ray µCT scans. They reveal the PFRPs’ unique ductile failure morphologies compared to common CFRPs. In addition, we heal the perforated region in the PFRPs by applying the manufacturing process identical to the initial curing process. The healed panels are perforated again, and they recovered 30% to 38% of their original specific energy absorption, a recovery not achievable with CFRPs. This study provides valuable experimental results, and concrete insights into the potential applications of recyclable PFRPs in various engineering fields. It emphasizes their excellent energy-absorbing capability and repairability.
Correlation between pelvic floor four-dimensional ultrasound parameters and POP-Q score
Authors: Li Zuling , Jiang Li , Xu Fei , Chen Qifang , Wang Fengmei , Lin Lisa 
Published: December 2024

Background Pelvic organ prolapse (POP) is a prevalent ailment that lowers a woman's quality of life and for which precise diagnosis techniques are required for successful treatment. Advanced imaging techniques may be beneficial for traditional clinical assessments like the Pelvic Organ Prolapse Quantification (POP-Q) system. Objectives The purpose of this study was to look into the relationship between the POP-Q score and four-dimensional pelvic floor ultrasonography parameters in women who have been diagnosed with pelvic organ prolapse. Methods We included 120 female patients who presented with symptoms consistent with pelvic floor dysfunction. Pelvic cancers, a history of hysterectomy, and the incapacity to execute Valsalva maneuvers were among the exclusion criteria. The pelvic floor was imaged in three dimensions using a color Doppler ultrasonography equipment (GE, Voluson E8 Edition) both at rest and during Valsalva maneuvers. Important variables, such as the posterior bladder angle and bladder neck distance, were examined and contrasted with POP-Q evaluations. Results According to the study, an ultrasonography was used to detect Green II prolapse in 63 individuals and Green III prolapse in 57 patients. The ultrasonography results and clinical POP-Q diagnosis agreed rather well (Kappa = 0.572). Furthermore, there was a substantial association found between the four-dimensional ultrasound characteristics and the POP-Q stages, suggesting that ultrasonography is a useful tool for visualizing pelvic floor structures. Conclusions According to the results, four-dimensional ultrasonography has a strong correlation with the POP-Q score and is a useful method for evaluating pelvic floor dysfunction. This imaging modality advances our knowledge of the dynamics of the pelvic floor and might lead to more accurate diagnoses for female patients with prolapsed pelvic organs.
Examining the Moderating Role of Affective Commitment on the Influence of Job Satisfaction on Intent to Stay: Evidence from Healthcare Technical Staff
Authors: Bandyopadhyay Chiradip 
Published: December 2024

Background Healthcare technical workers are responsible for service delivery and are indispensable to the organisation. However, being in a client facing role, they perform under client pressures thereby experiencing stress. The enormity of the healthcare industry ensures the existence of multiple competing organisations. Therefore, attrition is a cause of concern for these industries. Not only do organisations suffer as a consequence of such actions, the end users of such services may also be affected by attrition. Purpose The purpose of this study is to examine whether the intent to stay of healthcare workers is influenced by their job satisfaction and affective commitment. It also attempts to understand if affective commitment moderates the influence of job satisfaction on the intent to stay Methods The study has adopted a quantitative survey-based and primary data-based approach. The sample consists of technical healthcare staff such as medical imaging technicians, pathology laboratory technicians and medical equipment technicians. Two stage sampling has been adopted, with convenience sampling being used to approach private sector hospitals, and random sampling being used to select the respondents. Standard and established scales have been used in the study. Results The results indicate a significant correlation among job satisfaction, affective commitment and intent to stay. Further, the findings of analysis indicate that job satisfaction significantly influences the intent to stay. Affective commitment also significantly impacts the intent to stay. Moreover, affective commitment moderates the influence of job satisfaction on the intent to stay. Conclusion Healthcare organisations need to focus not only on enhancing the job satisfaction of healthcare staff but also pay attention effective commitment. They therefore need to focus not only on enhancing job skills and competencies but also provide a congenial organisation climate conducive to growth and development.
Successful Perinatal Management and Resection of Large Sacrococcygeal Teratoma in an Extremely Premature Neonate
Authors: Koe Emily , Elkhwad Mohammed , Bae Jae-O , Bhopal Navin 
Published: December 2024

Objectives Sacrococcygeal teratomas are the most frequently diagnosed fetal neoplasms, with premature birth remaining one of the greatest risk factors for poor prognosis. We report an exceptional case of survival to discharge of an extremely premature infant with a large sacrococcygeal teratoma (SCT). Case Presentation An extremely premature infant with a large SCT was delivered via Cesarean section at 27 weeks gestational age (GA) due to preterm labor. At birth, the SCT measured 14.2 × 11.6 × 8.4 cm, and was ruptured with mild hemorrhage that was controlled with topical hemostatic agent and compression. The infant required positive pressure ventilation and intubation at birth due to apnea. She was transferred from the birth hospital to a level IV neonatal intensive care unit for surgical management. She underwent urgent surgery early on second day of life because of worsening heart failure and ongoing hemorrhage from the capsular rupture. The infant survived to discharge on room air without any major complications. Conclusions Despite multiple negative prognostic factors, we report the success and feasibility of SCT management and repair at 27 weeks GA.