bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age-dependent differences in functional brain networks are atypical in Tourette syndrome
Authors: Nielsen Ashley N. , Gratton Caterina , Kim Soyoung , Church Jessica A. , Black Kevin J. , Petersen Steven E. , Schlaggar Bradley L. , Greene Deanna J. 
Published: April 2020

AbstractTourette syndrome (TS) is a neurodevelopmental disorder characterized by motor and vocal tics. TS is complex, with symptoms that involve sensory, motor, and top-down control processes and that fluctuate over the course of development. While many have studied atypical brain structure and function associated with TS, the neural substrates supporting the complex range and time-course of symptoms is largely understudied. Here, we used functional connectivity MRI to examine functional networks across the whole-brain in children and adults with TS. To investigate the functional neuroanatomy of childhood and adulthood TS, we separately considered the sets of connections within each functional network and those between each pair of functional networks. We tested whether developmental stage (child, adult), diagnosis (TS, control), or an interaction between these factors was present among these connections. We found that developmental changes for most functional networks in TS were unaltered (i.e., developmental differences in TS were similar to those in typically developing children and adults). However, there were several within-network and cross-network connections that exhibited either “divergent” or “attenuated” development in TS. Connections involving the somatomotor, cingulo-opercular, auditory, dorsal attention, and default mode networks diverged from typical development in TS, demonstrating enhanced functional connectivity in adulthood TS. In contrast, connections involving the basal ganglia, thalamus, cerebellum, auditory, visual, reward, and ventral attention networks showed attenuated developmental differences in TS. These results suggest that adulthood TS is characterized by increased functional connectivity among functional networks that support cognitive control and attention, which may be implicated in suppressing, producing, and attending to tics. In contrast, subcortical systems that have been implicated in the initiation and production of tics may be immature in adulthood TS. Jointly, our results reveal how several cortical and subcortical functional networks interact and differ across development in TS.
Supporting the digital professor: information, training and support
Authors: Coles Shanna , Martin Florence , Polly Drew , Wang Chuang 
Published: April 2020

PurposeThe purpose of this paper is to provide insight into institutions of higher education (IHE) on how to support faculty in the integration of digital technologies. The research explores faculty interest in types of digital technology information and training, and the types of support faculty are likely to participate in related to digital technology integration. The association of demographic factors of primary teaching method, and experience teaching online or hybrid is provided.Design/methodology/approachA sample of 247 faculty from 53 institutions in the USA completed an online survey related to information, training and support for digital technology integration. The analysis included exploring the descriptive ratings overall and by demographic variable and conducting the one-way multivariate analysis of variance (MANOVA) with reported effect sizes and Scheffe post-hoc tests.FindingsFrom a list of digital technologies that included the LMS, Collaboration Tools (social media and online meeting tools), Audio-Visual Tools (video creation and podcasts), and Technology Trends (mobile learning, games and adaptive learning), faculty ranked LMS highest in interest for training and information. Faculty who have taught hybrid are most interested in collaboration tools and trend tools. For support type, faculty ranked web resources slightly higher than other types of support.Practical implicationsIHE units involved in faculty development can use the findings to plan faculty support initiatives for future institutional needs.Originality/valueThis paper gathers insight from faculty on their preferences for information, training, and support for integrating digital technologies.
Siblingship beyond siblings? Cousins and the shadows of social mobility in the central Philippines
Authors: Cruz Resto 
Published: April 2020

AbstractThis article examines cousinship as a border zone that encompasses distance and intimacy, sameness and difference, and which mediates and is mediated by other kinship ties. It investigates how cousinship may bear traces of discord afflicting preceding generations; how it may further or augment them, or allow their repair; and how it is shaped by multiple and contending ideals. It does so in the context of social mobility in post‐1945 central Philippines. Integrating ‘old’ and ‘new’ kinship studies, it analyses cousinship beyond consanguineous marriages; revisits the paradigm of siblingship that has dominated the anthropology of kinship in Southeast Asia; and attends to how inequalities and enmities arise, and are absorbed, within kinship.
“My village fell apart”: Parents' Views on Seeking Informal Mentoring Relationships for Their Children
Authors: Weiler Lindsey M. , Keyzers Angela , Scafe Meredith , Anderson Amber , Cavell Timothy A. 
Published: April 2020

ObjectiveTo assess parents' perceptions of barriers and facilitators to promoting informal mentoring relationships for their children with caring adults in their existing social network.BackgroundSupportive relationships with nonparental adults are critical to positive youth development, social capital, healthy living, and upward mobility, but not all children experience such relationships. Because parents are the primary gatekeepers to children's social networks, we presumed that parents could play a role in shaping children's informal mentoring relationships.MethodWe conducted eight focus groups and used a semistructured interview to ask participants about mentoring and potential barriers or facilitators to connecting children with informal mentors. Participants were 55 parents/caregivers (Mage = 41.43 years; 96.4% female; 77.9% unmarried).ResultsParents were open to the involvement of nonparental adults in children's lives, but they differed in the extent to which their social network offered viable mentor candidates. Other barriers included feeling too proud to ask for help and concerns that informal mentors would be unsafe or inconsistent. Facilitative factors included appreciating the benefits of informal mentoring relationships, feeling connected to one's community, and being able and willing to ask for help in the face of doubt or fear.ConclusionParents were generally positive about children receiving support from informal mentors and acknowledged the potential role they could play in forming those connections; they also recognized potential barriers to making those connections.ImplicationsParents' perception about their “village” suggests the need to develop and evaluate programs that help parents connect children with supportive informal mentors.
Vimentin S‐glutathionylation at Cys328 inhibits filament elongation and induces severing of mature filaments in vitro
Authors: Kaus‐Drobek Magdalena , Mücke Norbert , Szczepanowski Roman H. , Wedig Tatjana , Czarnocki‐Cieciura Mariusz , Polakowska Magdalena , Herrmann Harald , Wysłouch‐Cieszyńska Aleksandra , Dadlez Michał 
Published: April 2020

Vimentin intermediate filaments are a significant component of the cytoskeleton in cells of mesenchymal origin. In vivo, filaments assemble and disassemble and thus participate in the dynamic processes of the cell. Post‐translational modifications (PTMs) such as protein phosphorylation regulate the multiphasic association of vimentin from soluble complexes to insoluble filaments and the reverse processes. The thiol side chain of the single vimentin cysteine at position 328 (Cys328) is a direct target of oxidative modifications inside cells. Here, we used atomic force microscopy, electron microscopy and a novel hydrogen–deuterium exchange mass spectrometry (HDex‐MS) procedure to investigate the structural consequences of S‐nitrosylation and S‐glutathionylation of Cys328 for in vitro oligomerisation of human vimentin. Neither modification affects the lateral association of tetramers to unit‐length filaments (ULF). However, S‐glutathionylation of Cys328 blocks the longitudinal assembly of ULF into extended filaments. S‐nitrosylation of Cys328 does not hinder but slows down the elongation. Likewise, S‐glutathionylation of preformed vimentin filaments causes their extensive fragmentation to smaller oligomeric species. Chemical reduction of the S‐glutathionylated Cys328 thiols induces reassembly of the small fragments into extended filaments. In conclusion, our in vitro results suggest S‐glutathionylation as a candidate PTM for an efficient molecular switch in the dynamic rearrangements of vimentin intermediate filaments, observed in vivo, in response to changes in cellular redox status. Finally, we demonstrate that HDex‐MS is a powerful method for probing the kinetics of vimentin filament formation and filament disassembly induced by PTMs.
Application and challenge of reflectance confocal microscopy in the diagnosis of pigmented nevus
Authors: Tang Zhen , Huang Jian , Lu Jianyun , Chen Jing , Guo Aiyuan , Ding Shu 
Published: April 2020

AbstractObjectiveTo investigate the application and challenge of reflectance confocal microscopy (RCM) in the diagnosis of pigmented nevus.MethodA total of 997 patients with clinical diagnosis of pigmented nevus were included in the study, and RCM imaging was performed on the lesion of each patient. A biopsy was performed in 78 of these patients for histological diagnosis. We retrospectively analyzed the results of RCM diagnosis and histological diagnosis and then found the RCM characteristics of the histologically confirmed lesion.ResultsAccording to the RCM images, 823 of the 997 (82.55%) patients were diagnosed with pigmented nevus, while 113 (11.33%) were not diagnosed by dermatologists using RCM. Of the 78 biopsy lesions, 36 of the 46 (78.26%) cases diagnosed with pigmented nevus were consistent with histological diagnosis, while three were rediagnosed with dermatofibromas, four were seborrheic keratosis, one was malignant melanoma in situ, and two were lentigo.ConclusionRCM exhibits a high diagnostic accuracy for patients with clinical diagnosis of pigmented nevus. However, due to the limitation of RCM scanning depth and the commonality of the microscopic characteristics of related diseases, RCM still faces certain challenges in the diagnosis of pigmented nevus.
Cancer stem cells and oral cancer: insights into molecular mechanisms and therapeutic approaches
Authors: Baniebrahimi Ghazaleh , Mir Fatemeh , Khanmohammadi Razieh 
Published: April 2020

AbstractCancer stem cells (CSCs) have been identified as a little population of cancer cells, which have features as the same as the cells normal stem cells. There is enough knowledge of the CSCs responsibility for metastasis, medicine resistance, and cancer outbreak. Therefore, CSCs control possibly provides an efficient treatment intervention inhibiting tumor growth and invasion. In spite of the significance of targeting CSCs in treating cancer, few study comprehensively explored the nature of oral CSCs. It has been showed that oral CSCs are able to contribute to oral cancer progression though activation/inhibition a sequences of cellular and molecular pathways (microRNA network, histone modifications and calcium regulation). Hence, more understanding about the properties of oral cancers and their behaviors will help us to develop new therapeutic platforms. Head and neck CSCs remain a viable and intriguing option for targeted therapy. Multiple investigations suggested the major contribution of the CSCs to the metastasis, tumorigenesis, and resistance to the new therapeutic regimes. Therefore, experts in the field are examining the encouraging targeted therapeutic choices. In spite of the advancements, there are not enough information in this area and thus a magic bullet for targeting and eliminating the CSCs deviated us. Hence, additional investigations on the combined therapies against the head and neck CSCs could offer considerable achievements. The present research is a review of the recent information on oral CSCs, and focused on current advancements in new signaling pathways contributed to their stemness regulation. Moreover, we highlighted various therapeutic approaches against oral CSCs.
Choice architecture interventions to change physical activity and sedentary behavior: a systematic review of effects on intention, behavior and health outcomes during and after intervention
Authors: Landais Lorraine L. , Damman Olga C. , Schoonmade Linda J. , Timmermans Danielle R. M. , Verhagen Evert A. L. M. , Jelsma Judith G. M. 
Published: April 2020

AbstractBackgroundChoice architecture interventions, which subtly change the environment in which individuals make decisions, can be used to promote behavior change. This systematic review aimed to summarize studies on micro-environmental choice architecture interventions that encouraged physical activity or discouraged sedentary behavior in adults, and to describe the effectiveness of those interventions on these behaviors – and on related intentions or health outcomes – in presence of the intervention and after removal of the intervention (i.e. post-intervention, regardless of the time elapsed).MethodsWe systematically searched PubMed, Embase, PsycINFO and the Cochrane Library for (quasi) experimental studies published up to December 2019 that evaluated the effect of choice architecture interventions on physical activity and sedentary behavior, as well as on intentions and health outcomes related to physical activity/sedentary behavior. Studies that combined choice architecture techniques with other behavior change techniques were excluded. All studies were screened for eligibility, relevant data was extracted and two independent reviewers assessed the methodological quality using the QualSyst tool.ResultsOf the 9609 records initially identified, 88 studies met our eligibility criteria. Most studies (n = 70) were of high methodologic quality. Eighty-six studies targeted physical activity, predominantly stair use, whereas two studies targeted sedentary behavior, and one targeted both behaviors. Intervention techniques identified were prompting (n = 53), message framing (n = 24), social comparison (n = 12), feedback (n = 8), default change (n = 1) and anchoring (n = 1). In presence of the intervention, 68% of the studies reported an effect of choice architecture on behavior, whereas after removal of the intervention only 47% of the studies reported a significant effect. For all choice architecture techniques identified, except for message framing, the majority of studies reported a significant effect on behavioral intentions or behavior in presence of the intervention.ConclusionsThe results suggest that prompting can effectively encourage stair use in adults, especially in presence of a prompt. The effectiveness of the choice architecture techniques social influence, feedback, default change and anchoring cannot be assessed based on this review. More (controlled) studies are needed to assess the (sustained) effectiveness of choice architecture interventions on sedentary behavior and other types of physical activity than stair use.
Daring to share requires intentional and collective commitment to civil discourse
Authors: Beets Michael W. , Weaver R. Glenn , Brazendale Keith 
Published: April 2020

AbstractCommunicating and challenging ideas through written scholarly dialogue is a cornerstone of scientific progress. In the current social and political climate, it is important to reflect upon what constitutes appropriate ways to engage in scholarly dialogues and consider the ramifications of failing to create an environment where individuals are willing to share ideas openly. In this commentary, we provide examples of scholarly dialogues representing antagonistic and collegial tones and discuss the consequences of failing to communicate appropriately in the areas of gatekeeping, mentoring, and most importantly, the silencing of ideas.
The role of Toll-like receptor signaling pathways in cerebrovascular disorders: the impact of spreading depolarization
Authors: Ashayeri Ahmadabad Rezan , Khaleghi Ghadiri Maryam , Gorji Ali 
Published: April 2020

AbstractCerebral vascular diseases (CVDs) are a group of disorders that affect the blood supply to the brain and lead to the reduction of oxygen and glucose supply to the neurons and the supporting cells. Spreading depolarization (SD), a propagating wave of neuroglial depolarization, occurs in different CVDs. A growing amount of evidence suggests that the inflammatory responses following hypoxic-ischemic insults and after SD plays a double-edged role in brain tissue injury and clinical outcome; a beneficial effect in the acute phase and a destructive role in the late phase. Toll-like receptors (TLRs) play a crucial role in the activation of inflammatory cascades and subsequent neuroprotective or harmful effects after CVDs and SD. Here, we review current data regarding the pathophysiological role of TLR signaling pathways in different CVDs and discuss the role of SD in the potentiation of the inflammatory cascade in CVDs through the modulation of TLRs.
Risk factors for pressure ulcers from the use of a pelvic positioner in hip surgery: a retrospective observational cohort study in 229 patients
Authors: Ueno Takuro , Kabata Tamon , Kajino Yoshitomo , Inoue Daisuke , Ohmori Takaaki , Yoshitani Junya , Ueoka Ken , Yamamuro Yuki , Tsuchiya Hiroyuki 
Published: April 2020

Abstract
Background
Intraoperatively acquired pressure ulcers are serious postsurgical complications requiring additional treatment, reoperation, and extended hospitalization. No study has investigated the frequency of the ulcers caused by compression with a pelvic positioner, which is used in hip surgeries to stabilize patients in the lateral decubitus position.

Methods
This retrospective study investigated the risk factors and the frequency of the ulcers caused by the use of pelvic positioners in hip surgeries. The records of patients who underwent surgical procedures under general anesthesia at our institution between January 1, 2016 and March 31, 2018 were reviewed. The inclusion criterion for the assessment of risk factors was hip surgery in the lateral decubitus position stabilized by a pelvic positioner. The exclusion criteria were patients with trauma, missing data, or a pre-existing pressure ulcer. Finally,.the study included 229 patients (265 hip surgeries). All the patients were positioned in the lateral decubitus position with the assistance of either a pelvic positioner, which had a single support fixture located over the pubic symphysis or a double support fixture located over the bilateral anterior superior iliac spine. Intraoperatively acquired pressure ulcers were diagnosed when ulcers were absent on admission and the redness that was observed immediately after surgery remained after 24 h. Multivariate analysis was used to identify factors associated with an increased risk for ulcers.

Results
Ulcers developed in 8 of 1810 (0.44%) patients who underwent orthopedic surgery. Seven of the 265 (2.64%) patients who underwent hip surgery in the lateral decubitus position stabilized by a pelvic positioner developed ulcers. All ulcers were located on areas of the body that were compressed by the pelvic positioner. After identifying controls for patient height (less than 154 cm), surgery duration (longer than 180 min), blood loss (more than 355 ml), and type of pelvic positioner used, we identified the independent risk factors for ulcers to be patient height < 154 cm (adjusted odds ratio, 12.8; p-value, 0.032) and the use of pelvic positioners with pubic bone support (adjusted odds ratio, 10.53; p-value, 0.047).

Conclusion
The use of pelvic positioners with pubic bone support should be avoided in patients with a height of < 154 cm to decrease the risk of ulcers.
Fit to fight – from military hygiene to wellbeing in the British Army
Authors: Bricknell Martin C. M. , Ross Colonel David A. 
Published: April 2020

AbstractThis paper reviews the historical evolution of the language and organization surrounding the health of personnel in the British Army from ‘hygiene’ through to ‘wellbeing’. It starts by considering the health of the army in the mid-nineteenth century and the emergence of military hygiene as a professional subject. It continues by looking at advances in military hygiene in the two world wars. Hygiene was replaced by the term ‘health’ in the 1950s as the collective noun used by professionals working in this field. This unity split when the professions of occupational medicine and public health established separate faculties and training pathways. However, the health issues for the armed forces remain fundamentally unchanged. Going forward, the term ‘wellbeing’ is helping to refresh the close relationships between executives, their medical advisers and those within the population of health professions charged with keeping the British Army healthy. The core theme is the collaborations between civil society, executive leadership and medical services in maximizing the health of the military population from recruitment through to life as a veteran.
The Sequential Radiographic Effects of Preoperative Chemotherapy and (Chemo)Radiation on Tumor Anatomy in Patients with Localized Pancreatic Cancer
Authors: Perri Giampaolo , Prakash Laura , Malleo Giuseppe , Caravati Andrea , Varadhachary Gauri R. , Fogelman David , Pant Shubham , Koay Eugene J. , Herman Joseph , Maggino Laura , Milella Michele , Kim Michael , Ikoma Naruhiko , Tzeng Ching-Wei , Salvia Roberto , Lee Jeffrey E. , Bassi Claudio , Katz Matthew H. G. 
Published: April 2020

Abstract
Background
The incidence and magnitude of indicators of radiographic response of pancreatic cancer to systemic chemotherapy and (chemo)radiation administered prior to anticipated pancreatectomy are unclear.

Methods
Sequential computed tomography scans of 226 patients with localized pancreatic cancer who received chemotherapy consisting of 5-fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFIRINOX) or gemcitabine and nanoparticle albumin-bound paclitaxel (GA) with or without (chemo)radiation and who subsequently underwent surgery with curative intent from January 2010 to December 2018 at The University of Texas MD Anderson Cancer Center and Verona University Hospital were re-reviewed and compared.

Results
Overall, 141 patients (62%) received FOLFIRINOX, 70 (31%) received GA, and 15 (7%) received both; 164 patients (73%) received preoperative (chemo)radiation following chemotherapy and prior to surgery; and 151 (67%), 70 (31%), and 5 (2%) patients had Response Evaluation Criteria in Solid Tumors (RECIST) stable disease, partial response, and progressive disease, respectively. The tumors of 29% of patients with borderline resectable or locally advanced cancer were downstaged after preoperative therapy. Radiographic downstaging was more common with chemotherapy than with (chemo)radiation (24% vs. 6%; p = 0.04), and the median tumor volume loss after chemotherapy was significantly greater than that after (chemo)radiation (28% vs. 17%; p < 0.01).

Conclusions
Less than one-third of patients treated with FOLFIRINOX or GA with or without (chemo)radiation experienced either RECIST partial response or radiographic downstaging prior to surgery. The incidence of tumor downstaging was higher and the magnitude of tumor volume loss was greater following chemotherapy than after (chemo)radiation.