bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tales of Landings and Legacies: African Americans in Georgia's Coastal Fisheries
Authors: Hoskins‐Brown Dionne L. 
Published: June 2020

AbstractPost‐civil war, African Americans developed communities in Georgia where traditional fishing practices created family fleets, processing plants, and other self‐sustaining fisheries work. The decline in African American fishermen since that period has been attributed to increased fishing costs, little access to capital, and a reluctance to have children work in labor‐intensive fisheries professions (Blount,MAST (Maritime Studies), 5, 2007, 5). Additionally, fluctuations in commercial landings may have had a negative influence. This study tested these hypotheses by comparing first‐hand accounts from current and former African American fishermen and their families with trends in Georgia fisheries data (1950–2015). Analyses of the histories and landings data indicated that African Americans fished the most abundant species during the years described by the participants (1950–1985) and that reasons for fishing or not fishing could be classified into 8 major themes related to work experience, Gullah Geechee values, and generational shifts.
Antennal sensory organs and glands of the harlequin ladybird, Harmonia axyridis
Authors: Sevarika Milos , Rondoni Gabriele , Conti Eric , Romani Roberto 
Published: June 2020

AbstractHarmonia axyridis (Pallas) (Coleoptera: Coccinellidae) is a sub‐cosmopolitan species. Native to Asia, it has been released during the 20th century for classical and augmentative biological control of several herbivorous insects, mostly aphids and coccids. Despite its recognized positive impact on biological control, H. axyridis is now considered among the most dangerous invasive species in Europe and in most places where it has established. This is mostly due to its ability to reduce the populations of native predatory species of the same trophic guild. When exploring a new area, H. axyridis adults use semiochemical cues to acquire information about the habitat. Presumably, these cues are perceived by the sensilla located on the antennae. Surprisingly, in spite of the huge literature existing on H. axyridis, the antennal sensory organs have been poorly characterized. Here, we used scanning and transmission electron microscopy (SEM, TEM) techniques to study H. axyridis antennae, with focus on the various types of sensilla and their distribution in male and female individuals. The presence of various classes of antennal sensilla belonging to the main types described in insects (chemoreceptors, mechanoreceptors, and thermo‐hygroreceptors) was highlighted, as well as the widespread presence of antennal glands. The investigations showed some peculiar characteristics not known in Coccinellidae, such as the concentration of sensory structures at the level of the distal part of the apical antennomere and the discovery of antennal glands associated with it. No sexual dimorphism was revealed, neither for the general structure of the antenna (similar number of antennomeres and presence of modifications), nor for the total length and width of the antenna, the relative size of the antennomeres, the types of antennal sensilla, of their distribution and abundance. The potential relevance of these sensory structures and antennal glands, reported for the first time in Coccinellidae, is discussed in the context of intra‐ and interspecific communication.
Effectiveness and safety of apixaban and rivaroxaban for acute venous thromboembolism therapy in patients with extremes in bodyweight
Authors: Wysokinski Waldemar E. , Froehling David A. , Houghton Damon E. , McBane Robert D. , Vlazny Danielle T. , Bott‐Kitslaar Dalene M. , Kuczmik Wiktoria , Sutkowska Karolina , Bator Kaja , Hodge David O. , Peterson Lisa G. , Casanegra Ana I. 
Published: June 2020

AbstractObjectivesTo investigate the association of extremes in bodyweight (EBW) and outcomes in patients with acute venous thromboembolism (VTE). Recurrent VTE, major bleeding, and clinically relevant non‐major bleeding were compared between patients with bodyweight <60 kg, 60‐120 kg, and >120 kg.MethodsConsecutive patients enrolled in the Mayo Clinic VTE Registry (03/28/2013‐8/31/2019) with acute VTE were followed prospectively. Patient status was assessed in person, by mailing a written questionnaire, or by a scripted phone interview.ResultsAmong 2577 patients with weight ranging from 27.0 kg to 263.2 kg, 2123 (82%) had a bodyweight between 60 and 120 kg, 223 (8.7%) had bodyweight < 60 kg, and 230 (8.9%) had bodyweight >120 kg. Patients with bodyweight <60 kg treated with DOACs had higher 3‐ and 6‐month incidence of major bleeding compared to the bodyweight 60‐120kg group (4.4% vs 1.1%, P = .03, and 4.4% vs 1.4%, P = .05, respectively). Patients with bodyweight >120 kg and cancer on rivaroxaban had higher VTE recurrence compared to bodyweight 60‐120kg group (P = .01).ConclusionsTreatment of acute VTE is associated with a higher incidence of bleeding in patients with bodyweight <60 kg. A higher VTE recurrence rate occurred only in cancer patients with bodyweight >120 kg on rivaroxaban.
Assessment of tumour proliferation by use of the mitotic activity index, and Ki67 and phosphohistone H3 expression, in early‐stage luminal breast cancer
Authors: van Steenhoven Julia E C , Kuijer Anne , Kornegoor Robert , van Leeuwen Gijs , van Gorp Joost , van Dalen Thijs , van Diest Paul J 
Published: June 2020

AimsPhosphohistone H3 (PhH3) has been proposed as a novel proliferation marker in breast cancer. This study compares the interobserver agreement for assessment of the mitotic activity index (MAI), Ki67 expression, and PhH3 in a cohort of oestrogen receptor (ER)‐positive breast cancer patients.Methods and resultsTumour samples of 159 luminal breast cancer patients were collected. MAI and PhH3 scores were assessed by three breast cancer pathologists. Ki67 scores were assessed separately by two of the three pathologists. PhH3‐positive cells were counted in an area of 2 mm2, with a threshold of ≥13 positive cells being used to discriminate between low‐proliferative and high‐proliferative tumours. Ki67 expression was assessed with the global scoring method. Ki67 percentages of <20% were considered to be low. The intraclass correlation coefficient (ICC) and Cohen's κ statistics were used to evaluate interobserver agreement. The impact on histological grading of replacing the MAI with PhH3 was assessed. Counting PhH3‐positive cells was highly reproducible among all three observers (ICC of 0.86). The κ scores for the categorical PhH3 count (κ = 0.78, κ = 0.68, and κ = 0.80) reflected substantial agreement among all observers, whereas agreement for the MAI (κ = 0.38, κ = 0.52, and κ = 0.26) and Ki67 (κ = 0.55) was fair to moderate. When PhH3 was used to determine the histological grade, agreement in grading increased (PhH3, κ = 0.52, κ = 0.48, and κ = 0.52; MAI, κ = 0.43, κ = 0.35, and κ = 0.32), and the proportion of grade III tumours increased (14%, 18%, and 27%).ConclusionPhH3 seems to outperform Ki67 and the MAI as a reproducible means to measure tumour proliferation in luminal‐type breast cancer. Variation in the assessment of histological grade might be reduced by using PhH3, but would result in an increase in the proportion of high‐grade cancers.
PCNP promotes ovarian cancer progression by accelerating β‐catenin nuclear accumulation and triggering EMT transition
Authors: Dong Pengzhen , Fu Hao , Chen Lin , Zhang Shihui , Zhang Xin , Li Huimin , Wu Dongdong , Ji Xinying 
Published: June 2020

AbstractEver reports showed that PCNP is associated with human cancers including neuroblastoma and lung cancer. However, the role and underlying molecular mechanism of PCNP in ovarian cancer have not been plenty elucidated. Herein, we first investigated the expression of PCNP in ovarian cancer tissues and cells, the effects of PCNP in ovarian cancer proliferation, apoptosis, migration and invasion, and determined the molecular mechanism of PCNP in ovarian cancer progression. The results indicated that PCNP was significantly overexpressed in human ovarian cancer tissues and cells, and related to poor prognosis in ovarian cancer patients. In addition, we also detected that PCNP promoted ovarian cancer cells growth, migration and invasion, as well as inhibited ovarian cancer cells apoptosis. Mechanistically, PCNP binding to β‐catenin promoted β‐catenin nuclear translocation and further activated Wnt/β‐catenin signalling pathway. Moreover, PCNP regulated the expression of genes involved in EMT and further triggered EMT occurrence. Conclusionally, PCNP may promote ovarian cancer progression through activating Wnt/β‐catenin signalling pathway and EMT, acting as a novel and promising target for treating ovarian cancer.
Systemic therapies for Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: a SCORTEN‐based systematic review and meta‐analysis
Authors: Torres‐Navarro I. , Briz‐Redón Á. , Botella‐Estrada R. 
Published: June 2020

AbstractBackgroundThe SCORTEN score is a specific predictor of mortality for patients with Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). There is little evidence in support of the common immunomodulating therapies for SJS/TEN.ObjectivesTo systematically assess the effectiveness of several therapies for SJS/TEN through the SCORTEN score.MethodsDatabases were searched for original studies on the use of SCORTEN. Six meta‐analyses were carried out on patients with SJS/TEN who received supportive care only or in combination with immunomodulating drugs: corticosteroids, cyclosporine, etanercept, immunoglobulins or a combination of corticosteroids with immunoglobulins. A multivariate meta‐regression and a network meta‐analysis were also performed.ResultsOf 3893 studies identified, fifty‐two involving 2466 patients with SJS/TEN were preselected. Data from thirty‐eight of these studies (1827 patients) were finally pooled, and results [log(SMR)] from meta‐analyses were as follows: −0.13 (95% CI, −0.42,0.16) for corticosteroids, −0.39 (95% CI, −0.87,0.09) for immunoglobulins, 0.13 (95% CI, −0.15,0.40) for supportive treatment, −0.88 (95% CI, −1.47, −0.29) for cyclosporine, −0.95 (95% CI, −1.82, −0.07) for etanercept and − 0.56 (95% CI, −0.94, −0.19) for immunoglobulins plus corticosteroids. The meta‐regression analysis confirmed that cyclosporine and immunoglobulins plus corticosteroids were associated with less deaths than predicted by SCORTEN. In the network meta‐analysis, no treatment achieved a significant reduction in the SMR.LimitationsHeterogeneity and quality of the included studies.ConclusionsSome treatments for SJS/TEN show a better performance, but there is not sufficient evidence to recommend its widespread use in all patients.
Botox rechallenge—An additional tool in the management of an incompletely emptying bladder and inadequate overactive symptom control following sacral neuromodulation
Authors: Timm Brennan , Jayarajan Jyotsna , Chan Garson , Bolton Damien 
Published: June 2020

AbstractTwo female patients aged 70 and 72 with video‐urodynamics‐confirmed detrusor overactivity and detrusor underactivity (DO‐DU) were treated. Patients were refractory to medical therapies and had previously failed intravesical botulinum toxin type A (BoNT‐A) at other centers secondary to urinary retention and difficulty with self‐catheterization. Placement of an Interstim II device (Medtronic, Minneapolis, Minnesota) for sacral neuromodulation (SNM) as alternative third‐line treatment partially improved overactive bladder (OAB) symptoms while significantly improving voiding symptoms. Postvoid residual (PVR) of patients improved from a median of 118 mL (110‐125 mL) to 20 mL (18‐26 mL) and 213 mL (195‐230 mL) to 70 mL (60‐73 mL), respectively. Addition of medical therapies post SNM failed to modify OAB symptoms further and a rechallenge with dose‐reduced BoNT‐A was undertaken.OAB symptoms were significantly improved by addition of BoNT‐A, while urinary retention was avoided (median PVR post BoNT‐A 38 mL [34‐40 mL] and 185 mL [150‐205 mL], respectively). Reduction in incontinence pad use as well as resolution of nighttime incontinence in both patients and daytime incontinence in one patient was achieved. DO‐DU patients treated by SNM who have improved bladder emptying (PVR <100 mL) but incomplete resolution of OAB symptoms should be trialed on adjunct medical therapies to improve OAB symptoms. If OAB symptoms are still inadequately controlled, consideration of a rechallenge with BoNT‐A, particularly with dose reduction, appears to be efficacious and avoids symptomatic retention in this challenging cohort.
UK mothers' experiences of bottle refusal by their breastfed baby
Authors: Maxwell Clare , Fleming Kate M. , Fleming Valerie , Porcellato Lorna 
Published: June 2020

AbstractLittle is known about bottle refusal by breastfed babies; however, an informal review of global online forums and social media suggested large numbers of mothers experiencing the scenario. This study aimed to explore UK mothers' experiences of bottle refusal by their breastfed baby in order to provide understanding of the scenario and enhance support for mothers experiencing it. A 22‐point online questionnaire was developed and completed by 841 UK mothers. Findings suggest that mothers introduced a bottle to their breastfed baby due to physical, psychological and socio‐cultural factors. Advice and support for mothers experiencing bottle refusal was not always helpful, and 27% of mothers reported bottle refusal as having a negative impact on their breastfeeding experience. When compared with eventual bottle acceptance, bottle refusal was significantly associated with previous experience of bottle refusal (p < .001), how frequently mothers intended to feed their baby by bottle and babies being younger at the first attempt to introduce a bottle (p < .001). This study provides a unique insight into the complexities of bottle refusal by breastfed babies and the impact it can have upon mothers' breastfeeding experiences. It generates knowledge and understanding that can help to inform practice and policies. In addition, a ‘normalising’ of the scenario could enable mothers, and those supporting them, to view and manage it more positively.
Erich Przywara’s Theology of Israel: A Critical Response to “Historical Criticism”
Authors: Betz John R. 
Published: June 2020

AbstractIn the Anglophone world the Jesuit philosopher and theologian Erich Przywara (1889‐1972) tends to be known almost exclusively to Balthasar and Barth scholars (as an important mentor to the former and a formidable nemesis of the latter). In recent years, however, interest in Przywara has grown beyond these circles, owing in part to the English translation of his magnum opus, Analogia Entis (2014), and a handful of articles and monographs on his thought. Indeed, it is gradually being recognized that Przywara was an important philosopher and theologian in his own right – of no less stature, and arguably profounder, than the most recognized names in modern theology – even if he did not possess the same oratorical gifts. At the same time, however, a shadow has been cast over this recovery effort since an American church historian named Paul Peterson accused Przywara, along with Balthasar and even Barth, of varying degrees of anti‐Semitism and fascist sympathies – charges that, were they true, would make one reluctant to read him or find out why Edith Stein, Balthasar, Rahner, Josef Pieper et al. thought so highly of him. The point of this article, accordingly, is to set the record straight, at least as far as Przywara’s supposed “anti‐Semitism” is concerned (his view of National Socialism will be treated separately). It is understandable, of course, that Peterson is troubled that theologians could have contributed to the conditions that led to the horrors of the Shoah; and this alone justifies the zeal of his investigations. But the unfortunate way he has conducted them has also come with a cost: in this case, the misrepresentation of the intentions and the unjust impugning of the character of an eminent theologian, from whom, according to Rahner and Balthasar – indeed, according to John Paul II, Benedict XVI, and Pope Francis – the church still has much to learn. But, as regrettable as this may be, Peterson’s investigations have also done a service for modern theology: not only have they occasioned a closer look at Przywara’s cultural and political views, which was overdue; they have also helped to uncover, however inadvertently, a distinctly Pauline theology of Israel, aspects of which may yet prove fruitful.
A pilot study on efficacy and tolerability of diaphragm pacing for amyotrophic lateral sclerosis
Authors: Ito Hisashi , Odake Sanae , Fukutake Shigeru , Kohriki Shunsaku , Kawachi Jun , Kamei Tetsumasa 
Published: June 2020

AbstractBackgroundThe efficacy and safety of diaphragm pacing (DP) for amyotrophic lateral sclerosis (ALS) patients has not been elucidated.AimTo investigate the efficacy and safety of DP for ALS in Japan.Materials and MethodsWe implanted the NeuRx RA/4 Diaphragm Pacing SystemR (NeuRx) in 5 ALS patients without tracheostomy mechanical ventilation and conditioned subsequently. Participants could combine NeuRx with non‐invasive ventilation such as biphasic positive airway pressure (BIPAP). The primary endpoint was overall survival, defined as the period from implantation to the administration of mechanical ventilation with tracheostomy or death.ResultsThree men and 2 women (59.6 ± 9.6 years old, 44 to 70 years old) underwent laparoscopic implantation of NeuRx. The survival differed considerably among individuals (20.7 ± 18.6 months, 5.0‐48.7 months). However, 2 patients with BIPAP showed longer survival. Breakage of the external cord connector occurred in 3 patients and focal epidermal infection occurred in two patients: however, these complications did not lead to serious conditions. An autopsy of one patient revealed no severe damage to the adjacent diaphragm tissue.ConclusionThe efficacy of NeuRx varied between individuals. The combination use of NeuRx with BIPAP might lead to longer survival than NeuRx alone. No serious safety issues were observed.
Child health care nurses’ use of teaching practices and forms of knowledge episteme, techne and phronesis when leading parent education groups
Authors: Forslund Frykedal Karin , Rosander Michael , Barimani Mia , Berlin Anita 
Published: June 2020

AbstractThis study explores child health care nurses’ pedagogical knowledge when supporting parents in their parenthood using various teaching practices, that is how to organise and process the content during parent education groups in primary health care. The aim is to identify teaching practices used by child health care nurses and to analyse such practices with regard to Aristotle's three forms of knowledge to comprehensively examine child health care nurses’ use of knowledge in practice. A qualitative methodological design alongside the analysis of video‐recordings was used. The results showed that child health care nurses used four teaching practices: lecturing, demonstration, conversation and supervision. Their use of episteme was prominent, but they also seemed to master techne in combination with episteme during the first three teaching practices. During the conversation teaching practice, the child health nurses rarely succeeded. Consequently, they missed opportunities to identify mothers’ expressed concerns and to act in the best interests of both the mothers and their infants by the use of phronesis. In health care, however, theoretical episteme is superordinate to productive knowledge or phronesis, which also became evident in this study. Nevertheless, more interactive pedagogical practices are needed if more use of phronesis is to become a reality in parent education groups.
Percutaneous endoscopic gastrostomy in small infants unable to swallow safely
Authors: Durakbasa Cigdem Ulukaya , Ozumut Sibel Hatice , Orhon Zeynep Nur , Caglar Oskayli Meltem , Aksu Burhan 
Published: June 2020

AbstractBackgroundData about percutaneous endoscopic gastrostomy (PEG) insertions in small infants are limited, and most studies include older children. We aimed to evaluate the safety of PEG placement in infants weighing ≤5 kg together with their follow‐up results.MethodsA retrospective evaluation was made of records between January 2005 and December 2019.ResultsA total of 43 infants were ≤5 kg at the time of PEG insertion. The mean age was 5 ± 3 (19 days–16 months) months and the mean weight was 4.3 ± 0.6 (2.7–5.0) kg. The primary diagnoses were neurological disorders in 25, metabolic disorders in nine, cleft palates in four, muscular disorders in four, and a cardiac disorder in one. All procedures were completed successfully. A self‐resolving pneumoperitoneum developed in one (2.3%). The tube was extruded in six (14%) patients postoperatively which required suture‐approximation of the skin and subcuticular tissues. The tube was removed in four (9%) patients with achievement of oral feeds on the long‐term. Eighteen (42%) died of primary diseases. The tubes were in situ for a median of 12.4 (17 days–73 months) months in these patients. A total of 20 (46.5%) patients are currently being followed up and their tubes are in situ for a median of 50.3 (4.7 month‐9.8 years) months.ConclusionsPercutaneous endoscopic gastrostomy placement is safe in small infants with associated morbidities. Complications related to the procedure are within acceptable limits. The accidental extrusion of the tube was a special consideration in this patient group. The overall mortality was high because of underlying primary diseases.
Proposing a new approach to measuring birth size asymmetry
Authors: Betts Kim S. , Kisely Steve , Alati Rosa 
Published: June 2020

AbstractBackgroundExisting methods of measuring birth size asymmetry based on ratios of growth parameters are clinically useful but simplistic, and as such may have limited usefulness in studies of aetiology.ObjectivesWe aimed to develop a novel method of measuring asymmetric fetal growth at birth and demonstrate its utility in characterising the perturbed growth associated with a number of prenatal exposures and neonatal outcomes.MethodsData were drawn from the Queensland (QLD) Perinatal Data Collection, which included all livebirths in the Australian state of QLD between July 2010 and December 2015, with analyses restricted to babies born between 32 and 42 weeks of gestation (n = 280 084). Novel measures of asymmetric birthweight, length, and head circumference were developed using a weighted average, representing “how far” an individual's given birth size measure deviated from the sample average and their other birth size measures. Associations among prenatal exposures and neonatal outcomes with the new asymmetry measures and traditional ratio measures (ie ponderal index, brain‐to‐body weight ratio, and birth length divided by head circumference) were then compared using log‐binomial and multinomial regressions.ResultsThe new asymmetry measures clearly indicated that prenatal smoking was linked to a disproportionate decrease in all birth size measures and that low birthweight asymmetry and low birth head circumference asymmetry were specifically associated with neonatal respiratory distress and chromosomal abnormalities, respectively. When these same associations were tested using the traditional ratios, the estimates were weak, imprecise, and non‐specific.ConclusionsWe developed a new approach to measuring fetal growth asymmetry which provides complimentary insights against the existing ratios approach. Associations with the new asymmetry measures were more precise and easier to interpret than the associations obtained using the ratios, and may better reflect the underlying pathological processes, providing an advantage when investigating the aetiologies of perturbed fetal growth.