bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generating asymmetry in a changing environment: cell cycle regulation in dimorphic alphaproteobacteria
Authors: van Teeseling Muriel C. F. , Thanbichler Martin 
Published: September 2020

AbstractWhile many bacteria divide by symmetric binary fission, some alphaproteobacteria have strikingly asymmetric cell cycles, producing offspring that differs significantly in their morphology and reproductive state. To establish this asymmetry, these species employ a complex cell cycle regulatory pathway based on two-component signaling cascades. At the center of this network is the essential DNA-binding response regulator CtrA, which acts as a transcription factor controlling numerous genes with cell cycle-relevant functions as well as a regulator of chromosome replication. The DNA-binding activity of CtrA is controlled at the level of both protein phosphorylation and stability, dependent on an intricate network of regulatory proteins, whose function is tightly coordinated in time and space. CtrA is differentially activated in the two (developing) offspring, thereby establishing distinct transcriptional programs that ultimately determine their distinct cell fates. Phase-separated polar microdomains of changing composition sequester proteins involved in the (in-)activation and degradation of CtrA specifically at each pole. In this review, we summarize the current knowledge of the CtrA pathway and discuss how it has evolved to regulate the cell cycle of morphologically distinct alphaproteobacteria.
Verschwörungsmentalität und Extremismus – Befunde aus Befragungsstudien in der Schweiz
Authors: Baier Dirk , Manzoni Patrik 
Published: September 2020

Zusammenfassung
Im Beitrag wird einerseits der Zusammenhang zwischen der Verschwörungsmentalität und gewaltbereiten extremistischen Einstellungen untersucht. Andererseits werden Einflussfaktoren der Verschwörungsmentalität betrachtet, wobei angenommen wird, dass anomische Einstellungen, eine Distanz zum politischen System und Autoritarismus die Zustimmung zu einer Verschwörungsmentalität erhöhen. Zur Prüfung der Annahmen wird auf zwei Befragungsstudien zurückgegriffen: eine schweizweite Jugendbefragung unter 8.317 Schülerinnen und Schülern und eine schweizweite Repräsentativbefragung unter 2.111 Erwachsenen. In beiden Stichproben zeigen sich weitestgehend vergleichbare Befunde: Anomische Einstellungen, geringes Institutionenvertrauen und politische Deprivation erhöhen die Zustimmung zur Verschwörungsmentalität, Autoritarismus hingegen nicht. Eine stärker ausgeprägte Verschwörungsmentalität wiederum erhöht die Zustimmung zu extremistischen Einstellungen, wobei dieser Zusammenhang in der Jugendstichprobe stärker ausgeprägt ist als in der Erwachsenenstichprobe.
A case of Williams syndrome with suspected coexisting ectopic aldosterone-producing tumor in the liver
Authors: Baba Shuhei , Miyoshi Arina , Obara Shinji , Usubuchi Hiroaki , Terae Satoshi , Sunahara Masao , Oshima Takahiro , Misawa Kazuhito , Tsuji Takahiro , Takahashi Bunya , Yamazaki Yuto , Sasano Hironobu , Wada Norio 
Published: September 2020

Summary
A 31-year-old man with Williams syndrome (WS) was referred to our hospital because of a 9-year history of hypertension, hypokalemia, and high plasma aldosterone concentration to renin activity ratio. A diagnosis of primary aldosteronism (PA) was clinically confirmed but an abdominal CT scan showed no abnormal findings in his adrenal glands. However, a 13-mm hypervascular tumor in the posterosuperior segment of the right hepatic lobe was detected. Adrenal venous sampling (AVS) subsequently revealed the presence of an extended tributary of the right adrenal vein to the liver surrounding the tumor. Segmental AVS further demonstrated a high plasma aldosterone concentration (PAC) in the right superior tributary vein draining the tumor. Laparoscopic partial hepatectomy was performed. The resected tumor histologically separated from the liver was composed of clear cells, immunohistochemically positive for aldesterone synthase (CYP11B2), and subsequently diagnosed as aldosterone-producing adrenal adenoma. After surgery, his blood pressure, serum potassium level, plasma renin activity and PAC were normalized. To the best of our knowledge, this is the first report of WS associated with PA. WS harbors a high prevalence of hypertension and therefore PA should be considered when managing the patients with WS and hypertension. In this case, the CT findings alone could not differentiate the adrenal rest tumor. Our case, therefore, highlights the usefulness of segmental AVS to distinguish adrenal tumors from hepatic adrenal rest tumors.

Learning points:

Williams syndrome (WS) is a rare genetic disorder, characterized by a constellation of medical and cognitive findings, with a hallmark feature of generalized arteriopathy presenting as stenoses of elastic arteries and hypertension.

WS is a disease with a high frequency of hypertension but the renin-aldosterone system in WS cases has not been studied at all.

If a patient with WS had hypertension and severe hypokalemia, low PRA and high ARR, the coexistence of primary aldosteronism (PA) should be considered.

Adrenal rest tumors are thought to arise from aberrant adrenal tissues and are a rare cause of PA.

Hepatic adrenal rest tumor (HART) should be considered in the differential diagnosis when detecting a mass in the right hepatic lobe.

Segmental adrenal venous sampling could contribute to distinguish adrenal tumors from HART.
A case of testicular atrophy associated with cystic fibrosis
Authors: Profka Eriselda , Rodari Giulia , Giacchetti Federico , Berrettini Alfredo , Manzoni Gianantonio , Daccò Valeria , Arosio Maura , Giavoli Claudia , Colombo Carla 
Published: September 2020

Summary
An 8-year-old boy with cystic fibrosis came to our attention for an empty scrotum. General physical examination showed a normal penis and hypoplastic scrotum with non-palpable testes bilaterally. Routine blood investigations showed low levels of LH, testosterone, inhibin B and antiMullerian hormone and elevated levels of FSH. Karyotype was normal. An abdominal ultrasound confirmed the absence of the testes into the scrotum, in the inguinal region and abdomen. At laparoscopy were noted bilaterally hypotrophic spermatic vessels, absence of the vas deferens and a closed inner ring. Inguinal exploration found out a small residual testis and histological examination showed fibrotic tissue. This is the first case of testicular atrophy associated to CFTR mutation described. The process that led to bilateral testicular and vas deferens atrophy remains unexplained, a possible influence of CFTR dysfunction cannot be ruled out, although it is possible that these conditions are independently associated.

Learning points:

Cystic fibrosis produces a multisystemic disease which can affect also the reproductive tract.

Nearly 97–98% of male patients are infertile because of congenital bilateral absence of vas deferens.

A correlation between cystic fibrosis and bilateral testicular atrophy could be possible.
Identification of a TMEM127 variant in a patient with paraganglioma and acromegaly
Authors: Stütz Beryl , Korbonits Marta , Kothbauer Karl , Müller Werner , Fischli Stefan 
Published: September 2020

Summary
The coincidence of a pheochromocytoma or paraganglioma and a pituitary adenoma in the same patient is a rare condition. In the last few years SDHx and MAX mutations have been identified and discussed as a potential causal connection in cases of coincidence. We describe a case of a middle-aged female patient which presented with acromegaly, a growth hormone-secreting pituitary adenoma and a symptomatic neck paraganglioma. The patient was cured by surgery from both the pituitary tumour and the paraganglioma and is well after ten years follow-up. Due to the unusual coexistence of two neuroendocrine tumours, further molecular genetic testing was performed which revealed a variant in the TMEM127 gene (c245-10C>G).

Learning points:

Pheochromocytoma/paraganglioma and coexisting functioning pituitary adenoma are a very rare condition. An appropriate treatment of each tumour entity with a multi-disciplinary approach and regular follow-up is needed.

The possibility of a hereditary disease should be considered and genetic workup is recommended. Genetic testing should focus primarily on the genes with mutations related to pheochromocytomas and paragangliomas.

Next-generation sequencing with multi-gene panel testing is the currently suggested strategy.

Genes associated with paragangliomas and pituitary adenomas are SDHA, SDHB, SDHC, SDHD, SDHAF2, MAX and MEN1, while case reports with VHL, RET and NF1 may represent coincidences.

Variants of uncertain significance may need ongoing vigilance, in case novel data become available of these variants.
Bimbingan Agama Melalui Program Dauroh Qolbiyah Dalam Membentuk Kepribadian Muslim
Authors: Usman Nurul Qomaria , Sumpena Deden , Saepulrohim Asep 
Published: September 2020

ABSTRAK
Tulisan ini bertujuan untuk mengetahui pelaksanaan bimbingan agama melalui program Dauroh Qolbiyah, pengaruh program Dauroh Qolbiyah terhadap pembentukan kepribadian muslim. Metode penelitian ini menggunakan metode deskriptif dengan teknik pengumpulan data yaitu wawancara, observasi, dan studi dokumentasi. Penelitian ini menggunakan analisis data dengan analisis kualitatif. Hasil penelitian ini menunjukkan bahwa bimbingan agama melalui program Dauroh Qolbiyah menggunakan metode ceramah, diskusi, ta’lim bil lu’wah atau simulasi serta metode campuran. Materi yang diberikan dalam program Dauroh Qolbiyah terdiri dari akidah, ibadah, akhlak, dan pembiasaan ibadah wajib maupun ibadah sunnah. Program Dauroh Qolbiyah tidak dapat dianggap berhasil dalam membentuk kepribadian muslim. Namun program Dauroh Qolbiyah dianggap sebagai program pembiasaan yang dapat membentuk kepribadian muslim.
Kata Kunci : Bimbingan Agama; Dauroh Qolbiyah; Kepribadian Muslim

ABSTRACT
This paper aims to find out the implementation of religious guidance through the Dauroh Qolbiyah program, the influence of the Dauroh Qolbiyah program on the formation of Muslim personalities. This research method uses descriptive method with data collection techniques namely interviews, observation, and documentation studies. This study uses data analysis with qualitative analysis. The results of this study indicate that religious guidance through the Dauroh Qolbiyah program uses the lecture method, discussion, ta'lim talk or simulation and mixed methods. The material provided in the Dauroh Qolbiyah program consists of faith, worship, morality, and compulsory worship and sunnah worship. The Dauroh Qolbiyah program cannot be considered successful in shaping the Muslim personality. But the Dauroh Qolbiyah program is considered as a habituation program that can shape Muslim personalities.
Keywords: Religious Guidance; Dauroh Qolbiyah; Muslim personality
Pesan Dakwah dalam Novel Athirah
Authors: Herlina Nina , Amin Dang Eif Saiful , Aziz Rohmanur 
Published: September 2020

ABSTRACTThis paper aims to determine how the macro-structure of the novel Athirah propaganda message, superstructure message Athirah propaganda in the novel, and the microstructure of propaganda messages in the novel Athirah Endah Alberthiene work. The research method using the method of discourse analysis approach is qualitative, in discourse analysis Teun A. Van Dijk models is researching on the search for the macro-structure of thematic text. while the superstructure is discussed in the schematic, and the microstructure of the text that is in terms of semantic, syntactic, stylistic and rhetorical. The results showed that in the structure of the macro in this novel are arranged in the theme of patience, and a woman named Athirah toughness in the face of life's trials. In the superstructure Alberthiene Endah make this novel with the flow back and forth, there are grooves that tell of the past, but still easily understood by the reader. While the microstructure Alberthiene Endah using language that is quite extensive and figurative language or imagery. Tenses used mostly using active voice form.
ABSTRAKTulisan ini bertujuan untuk mengetahui bagaimana struktur makro pesan dakwah dalam novel Athirah, Superstruktur pesan dakwah dalam novel Athirah, dan struktur mikro pesan dakwah dalam novel Athirah karya Alberthiene Endah. Metode penelitian menggunakan metode pendekatan analisis wacana bersifat kualitatif, Dalam analisis wacana model Teun A. Van Dijk ini meneliti tentang mencari struktur makro teks tentang tematik. sedangkan superstruktur dibahas dalam skematik, dan struktur mikro teks yaitu dari segi semantik, sintaksis, stilistik dan retoris. Hasil penelitian menunjukan yaitu secara struktur makro dalam novel ini disusun dalam tema kesabaran, dan ketangguhan seorang perempuan bernama Athirah dalam menghadapi cobaan hidup. Secara superstruktur Alberthiene Endah membuat novel ini dengan alur maju mundur, ada alur yang menceritakan masa lampau, namun tetap mudah dimengerti oleh pembaca. Sedangkan secara struktur mikro Alberthiene Endah menggunakan bahasa yang cukup luas dan bahasa kiasan atau perumpamaan. Bentuk kalimat yang digunakan kebanyakan menggunakan bentuk kalimat aktif.
Komik Sebagai Media Dakwah
Authors: Faza Adilah Siti Ulya , Ridwan Aang , Solahudin Dindin 
Published: September 2020

Komik merupakan media kontenporer yang berkembang dengan pesat pada meda sosial masa kini. Komik strip pada akun instagram @Blackmetalistiqomah, memiliki tujuan untuk menyiarkan dakwah Islam. Tujuan Penelitian ini adalah untuk menjelaskan lebih dalam mengenai komik sebagai media dakwah. Mendalami aspek meteri dakwah dan metode dakwah pada komik strip di akun instagram @Blackmetalistiqomah. Penelitian ini menggunakan analisis deskriptif, semiotika Charles S Pierche. Pada komik @Blackmetalistiqomah memiliki hubungan isyarat, objek dan makna. Tanda berkaitan dengan objek yang meyerupainya dan menghasilkan sebab akibat. Setiap penggambaran dalam komik memiliki unsur ikun, ideks dan simbol yang memiliki unsur dari dakwah. Hasil penelitian menunjukan bahwa Materi dakwah telah digambar oleh komikus, memiliki pola yang berlandaskan Al-Quran dan hadis. Setelah materi sudah terbentuk maka komikus yaitu Achmad Deptian merepresentasikan melalui gambar-gambar yang lebih menarik perhatian anak-anak muda, menggunaka bahasa yang sederhana, materi yang ringan. Metode yang digunakan pada Black Metal Istiqomah dalam menyampaikan pesan islam menggunakan tiga metode yaitu bil hikmah, Al-Mauidzha Alh-Hasanah, Bit-Tadwin.
ABSTRACT
Comics is a content media that is growing rapidly at present. Strip comics on the @Blackmetalistiqomah instagram account have the purpose of broadcasting Islamic propaganda. The purpose of this research is to explain more about comics as a medium of da'wah. Deepening aspects of da'wah method and method of da'wah on comic strips on @Blackmetalistiqomah instagram account. This study uses descriptive analysis, Charles S Pierche's semiotics. In the comic @Blackmetalistiqomah has a signal, object and meaning relationship. The sign is related to the object that resembles it and produces cause and effect. Each depiction in comics has elements of icon, ideks and symbols that have elements of da'wah. The results of the study show that the da'wah material has been drawn by comic artists, has a pattern based on the Quran and hadith. After the material has been formed, the comic artist, Achmad Deptian, represents through drawings that attract the attention of young people, using simple language, light material. The method used in Black Metal Istiqomah in conveying the message of Islam uses three methods, namely bil hikmah, Al-Mauidzha Alh-Hasanah, and Bit-Tadwin.
Pesan Dakwah Dalam Album "Masih Ada Waktu" Karya Ebiet G Ade
Authors: Muhamad Ropik Abdul , Setiana Wiryo , Saepudin Nase 
Published: September 2020

Tujuan dari penelitian ini adalah untuk mengetahui pesan dakwah yang terdapat di dalam lirik-lirik lagu Ebiet G Ade yang terusung didalam album berjudul “ Masih Ada Waktu”, yang mencakup pesan Akidah, Ahlak dan Syariah. Metode yang digunakan adalah penelitian kualitatif dengan pendekatan analisi isi, dan merupakan sebuah usaha yang dilakukan untuk mendapatkan penjelasan dari isi pesan yang ada di dalam bentuk verbal dan non verbal.. Teknik pengumpulan data dalam penelitian ini menggunakan tehnik studi kepustakaan, yaitu dengan cara membaca, mencatat, mengolah data dan mengetahui biografi/kepustakaan. Hasil penelitian menunjukan, lagu-lagu Ebiet yang terdapat pada album “Masih Ada Waktu” menunjukan adanya nilai dan pesan dakwah, pesan Akidah, Ahlak dan Syariah di dalamnya, karena lirik lagu yang dibawakan tidak bertetangan dengan Al-Qur’an dan Hadits. Hal ini terbukti pada bagaimana cara Ebiet menciptakan lirik-lirik lagu yang bermakna kemanusiaan, alam, lingkungan, keTuhanan dan sebagainya.
Kata Kunci: Pesan Dakwah, Lirik Lagu, Ebiet G Ade.

The purpose of this study was to find out the da'wah messages contained in Ebiet G Ade's song lyrics which continued in the album entitled "Masih Ada Waktu", which included the message of Akidah, Ahlak and Sharia. The method used is qualitative research with the content analysis approach, and is an attempt made to get an explanation of the contents of the message that is in the form of verbal and non-verbal. Data collection techniques in this study use library study techniques, namely by reading, record, process data and know biography / literature. The results showed, Ebiet songs contained in the album "Masih Ada Waktu" showed the value and message of da'wah, the message of Akidah, Ahlak and Sharia in it, because the song lyrics that were sung were not in line with the Qur'an and Hadith. This is evident in how Ebiet creates song lyrics that mean humanity, nature, environment, divinity and so onKeywords: Da'wah Message, Song Lyrics, Ebiet G Ade.
Manajemen Majelis Taklim dalam Meningkatkan Fungsi Masjid
Authors: Hakim Arif Rahman , Anwar Saeful , Setiawan Asep Iwan 
Published: September 2020

Wakaf produktif merupakan langkah baru dalam memberdayakan potensi wakaf yang ada di indonesia, pengelolaan wakaf menjadi sebuah hal yang sangat penting dalam mengukur sejauhmana efektifitas dan efisiensi yang didapat dari wakaf produktif tersebut. Oleh karena itu langkah pengorganisasian merupakan langkah awal dalam membangun wakaf produktif yang baik. Penelitian ini menggunakan metode deskriptif, yaitu untuk menggambarkan keadaan secara riil di tempat penelitian secara sistematis fakta, baik data deskriptif berupa kata-kata tertulis atau lisan dari orang-orang yang berkaitan dengan pengorganisasian Badan wakaf Indonesia wilayah Jawa Barat. Berdasarkan hasil penelitian yang dilakukan di Badan Wakaf Indonesia Wilayah Jawa Barat, Langkah pengorganisasian yang dilakukan oleh Badan Wakaf Indonesia Jabar yaitu, Pertama Spesialisasi kerja yang telah disusun dalam peraturan Badan Wakaf Indonesia no 1 tahun 2008 dan dalam UUD No 41 tahun 2004, yang dimana anggota memiliki kompetensi dan ahli pada bidang Hukum, ekonomi syariah, cendekiawan, nazhir dan kewirausahaan. Kedua departementalisasi dimana anggota yang memiliki kompetensi tersebut di bagi kedalam 5 divisi sesuai dengan kompetensi dan keahlian masing-masing. Ketiga pendelegasian wewenang, 5 divisi tersebut diberikan wewenang oleh ketua secara penuh dalam menjalankan tugas tugas yang diembannya. Dan keempat rantai komando, dalam hal ini garis koordinasi yang diterapkan oleh Badan Wakaf Indonesia langsung terhubung dari kelima divisi kepada ketua.

Productive endowments are a new step in empowering the waqf potential in Indonesia, the management of waqf is a very important thing in measuring the extent to which effectiveness and efficiency can be obtained from the productive waqf. Therefore the organizing step is the first step in building a good productive waqf. This study uses a descriptive method, which is to describe the situation in real terms in a systematic place of research, both descriptive data in the form of written or verbal words from people related to the organization of the Indonesian Waqf Board in West Java. Based on the results of research conducted at the Indonesian Waqf Board in West Java, the organizing steps taken by the Indonesian Waqf Board are West Java, namely, the First Specialization work that was compiled in the Indonesian Waqf Agency Regulation No. 1 of 2008 and in the Constitution No. 41 of 2004, which members has competence and expertise in the fields of Law, Islamic economics, intellectuals, Nazhir and entrepreneurship. Both departments where members who have these competencies are divided into 5 divisions according to their respective competencies and expertise. All three delegations of authority, 5 divisions were given full authority by the chairman in carrying out the duties assigned. And the fourth chain of command, in this case the coordination line applied by the Indonesian Waqf Board is directly connected from the five divisions to the chairman.
Manajemen Mutu Outcome Penyelenggaraan Ibadah Haji
Authors: Rohman Cecep Abdu , Kusnawan Aep , Yuliani Yuliani 
Published: September 2020

Penelitian ini menggambarkan mutu kepuasan pelayanan ibadah haji; untuk memperoleh gambaran mutu kemabruran jemaah haji; dan dampak alumni jemaah haji di tengah masyarakat setelah melaksanakan ibadah haji yang diselenggarakan oleh kantor wilayah Kementerian agama Provinsi Jawa Barat. Metode penelitian ini menggunakan metode deskriptif, jenis data yang di gunakan adalah kulitatif, sumber data yang digunakan adalah data primer dan juga sekunder adapun teknik pengumpulan data yang digunakan dalam penelitian adalah observasi, wawancara, dan studi dokumentasi. Adapun analisis data dilakukan melalui penafsiran logika yang dihubungkan dengan konteks Manajemen Dakwah. Hasil penelitian menunjukkan bahwa: Pertama, Kanwil Kemenag Jabar bidang haji dan Umrah dalam meraih kesuksesannya memperhatikan tahapan-tahapan, yaitu: Perencanaan; Pengorganisasian; Pelaksanaan pelayanan pada jemaah haji. Kedua, Mutu kemabruran jemaah haji didasarkan pada perubahan sikap jemaah haji yang lebih baik. Ketiga, Dampak alumni haji ditengah masyarkat. Secara umum penelitian ini dapat disimpulkan bahwa manajemen mutu suatu penyelenggara ibadah haji menghasilkan outcome dari alumni jemaah haji yang mabrur dan memiliki manfaat yang fositif ditengah masyarakat.
This study describes the quality of satisfaction of Hajj services; to obtain a picture of the quality of the pilgrims' journey; and the impact of alumni of pilgrims in the community after performing the pilgrimage held by the office of the Ministry of Religious Affairs of West Java Province. This research method using descriptive method, the type of data that is used is leather, the data source used is primary data and also the secondary data collection techniques used in the research are observation, interview, and documentation study. The data analysis is done through the interpretation of logic that is connected with the context of Da'wah Management. The results showed that: First, Kanwil Kemenag Jabar field of pilgrimage and Umrah in achieving its success attention to the stages, namely: Planning; Organizing; Implementation of service to pilgrims. Second, the quality of the pilgrims' pilgrimage is based on a better attitude of pilgrims. Third, the impact of Hajj alumni in the community. In general, this study can be concluded that the quality management of a pilgrimage provider produces outcomes from alumni pilgrims who mabrur and has a fossil benefits in the community.