bluuebunny/crossref_metadata_2025_split huggingface dataset:
Musculoskeletal Consequences of COVID-19
Authors: Disser Nathaniel P. , De Micheli Andrea J. , Schonk Martin M. , Konnaris Maxwell A. , Piacentini Alexander N. , Edon Daniel L. , Toresdahl Brett G. , Rodeo Scott A. , Casey Ellen K. , Mendias Christopher L. 
Published: May 2020

Abstract:
Coronavirus disease 2019 (COVID-19) is an emerging pandemic disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although the majority of patients who become infected with SARS-CoV-2 are asymptomatic or have mild symptoms, some patients develop severe symptoms that can permanently detract from their quality of life. SARS-CoV-2 is closely related to SARS-CoV-1, which causes severe acute respiratory syndrome (SARS). Both viruses infect the respiratory system, and there are direct and indirect effects of this infection on multiple organ systems, including the musculoskeletal system. Epidemiological data from the SARS pandemic of 2002 to 2004 identified myalgias, muscle dysfunction, osteoporosis, and osteonecrosis as common sequelae in patients with moderate and severe forms of this disease. Early studies have indicated that there is also considerable musculoskeletal dysfunction in some patients with COVID-19, although long-term follow-up studies have not yet been conducted. The purpose of this article was to summarize the known musculoskeletal pathologies in patients with SARS or COVID-19 and to combine this with computational modeling and biochemical signaling studies to predict musculoskeletal cellular targets and long-term consequences of the SARS-CoV-2 infection.
Matrix-Induced Autologous Chondrycte Implantation for a Glenoid Chondral Defect
Authors: Steinmetz Garrett , Hamilton John , Fernandes Carl , Bond James 
Published: May 2020

Case:
We describe the case of a 33-year-old man who had a 1.5 × 2 cm chondral defect of the right glenoid that that was discovered on arthroscopy and was successfully treated with matrix-induced autologous chondrocyte implantation (MACI). At 2 years postoperatively, the patient's Constant score and American Shoulder and Elbow Surgeons (ASES) shoulder score improved by 44 and 51.6 points, respectively.

Conclusion:
Chondral lesions of the glenoid are rare and are a challenge to manage. This case represents a successful outcome with MACI, thus providing surgeons with an option for treating these difficult problems.
Antibiotic-Impregnated Intramedullary Cement Nail-Induced Acute Generalized Exanthematous Pustulosis and Septic Shock
Authors: Mitchell Brendon , Girard Paul J. , Kent William T. 
Published: May 2020

Case:
A 28-year-old woman with an infected proximal femur nonunion was treated with an antibiotic-coated intramedullary nail. Shortly after discharge, the patient presented to the emergency department and was readmitted with a morbilliform rash sparing the left lower extremity. She became hemodynamically unstable, despite cessation of intravenous antibiotics, requiring transfer to the intensive care unit and urgent removal of her antibiotic nail. She improved after surgery, and biopsy results from the rash confirmed acute generalized examthematous pustulosis.

Conclusion:
Acute generalized exanthematous pustulosis is a rare, dermatologic crisis that can be precipitated by antibiotics, even in the form of antibiotic cement.
Technical Revisions Reveal Overconfidence in US and Canadian Reserves Estimates
Authors: Gomez Diana , McVay Duane , Lee John 
Published: May 2020

Summary
In this paper, we present methodology to quantify biases in reserves estimates using technical revisions (TRs) listed in reserves-reconciliation reports filed with regulators in the US and Canada. Using this methodology, we assessed the reliability of reserves estimates for 34 companies filing in Canada and 32 companies filing in the US from 2007 to 2017.
Filers in both Canada and the US overestimated proved (1P) reserves, and US filers overestimated 1P reserves (51% positive TRs instead of 90%) more often than Canadian filers (72% positive TRs). Canadian filers underestimated proved-plus-probable (2P) reserves slightly (54% positive TRs instead of 50%). Considering the entire reserves distribution, Canadian filers were moderately overconfident (underestimated uncertainty) and slightly pessimistic. US filers, who report only 1P, were somewhere between the combination of extreme overconfidence and neutral directional bias (DB) and the combination of moderate overconfidence and extreme optimism.
Three groups of professionals can benefit from this study: estimators, who can use the methodology to track their TRs over time, calibrate them, and use this information to improve future estimation procedures; investors, who can analyze reported reserves estimates to compare volumes fairly; and regulators, to whom the paper provides quantitative methodology to suggest to filers to help them ensure compliance with appropriate criteria for 1P and 2P reserves and avoid significant reserves write-downs later.
Three-Dimensional Modeling of Mineral/Elemental Compositions for Shale Reservoirs
Authors: Ma Y. Z. 
Published: May 2020

Summary
Mineral compositional analysis of rocks is important for developing shale resources because the relationships between mineral compositions and petrophysical properties are critical for resource evaluation and completion optimization. Elementary properties are now routinely analyzed at wells in evaluating shale reservoirs. However, these properties have not been modeled in the three-dimensional (3D) reservoir. This is because an elemental composition has a physical constraint that is relatively easily adhered to in data analysis for wells but not in 3D modeling of reservoirs. A critical condition of elemental composition is that the sum of its components is equal to 100% to honor the mass-preservation principle. Traditional modeling methods do not satisfy this physical condition, sometimes producing nonphysical values, such as negative porosity values and fluid-saturation values greater than 100%. To date, only the compositional-modeling methods using a log-ratio transform can consistently satisfy this physical constraint. This paper presents modeling methods using additive log-ratio transform for modeling mineral compositions.
Unsafe child feces disposal status in Ethiopia: what factors matter? analysis of pooled data from four demographic and health surveys
Authors: Sahiledengle Biniyam 
Published: May 2020

Abstract
Background: The only safest way to dispose of a child’s feces is to help the child use a toilet or, for very young children, to put or rinse their feces into a toilet; whereas all other disposals are considered unsafe (feces put/rinsed into a drain or ditch, bush or thrown into the garbage, buried or left on the ground, and not disposed of). The study aims to determine the magnitude and factors associated with unsafe child feces disposal in Ethiopia.Methods: The study is cross-sectional in nature and based on the pooled data from the four rounds of Demographic and Health Surveys (DHS) conducted in Ethiopia (2000-16). Data on child feces disposal practice was collected for all children born during the five years preceding survey. To get detail about the disposal of children’s feces, mothers of under-five children were asked, “The last time passed stools, what was done to dispose of the stools?” with respect to the youngest child born. Descriptive statistics were computed to illustrate the given data. Multivariable logistic regression was performed to identify factors associated with unsafe child feces disposal. Results: The pooled dataset contains data for 40,520 children younger than 5 years, male accounts 20,629 (50.9%). Overall, 77.7% (95%CI: 76.3-79.0) of children feces disposed of unsafely. In the multivariable logistic regression model, those mothers whose child was 13-24 months [AOR: 0.68, 95% CI: (0.60-0.78)] and ≥ 25 months [AOR: 0.66, 95% CI: (0.60-0.72)] were lower odds of unsafe child’s feces disposal. Children born into households having two or fewer children were 33% lower [AOR: 0.67, 95% CI: (0.56-0.79)] odds of unsafe child’s feces disposal than their counterparts. The odds of disposing of feces unsafely among households having improved toilet facility was 76% lower [AOR: 0.24, 95% CI: (0.19-0.29)] that of households lacking such facilities. Further, being an urban resident, having improved drinking water facility, a high level of maternal and paternal education, paternal occupational status (work in non-agriculture), and maternal age (25-34 and ≥ 35 years) were factors associated with lower odds of unsafe child's feces disposal.Conclusions: Three in four Ethiopian children feces disposed of unsafely. Household and socio-demographic factors, such as access to improved water and toilet facility, area of a resident (urban), the child’s age (older age), and both higher maternal and paternal education levels were significantly associated with lower odds of unsafe child feces disposal.
Ethnomedicinal knowledge of a marginal hill community of Central Himalaya: Diversity, usage pattern and conservation concerns
Authors: Ojha S. N. , Tiwari Deepti , Anand Aryan , Sundriyal R.C. 
Published: May 2020

Abstract
Background

Indigenous communities use wild plants to cure human ailments since ancient times, such knowledge has significant potential for formulating new drugs and administering future health care. Considering this the present study was undertaken to assess use value, diversity, and conservation concerns of medicinal plants used in traditional herbal care system of a marginal hill community in Bageshwar district of Uttarakhand in the Central Himalayan region of India.

Methodology

Extensive surveys were made in 73 villages to gather information on ethnomedicinal use of plant species used in traditional herbal healing system. A total of 100 respondents were identified (30 herbal healers called ‘ Vaidyas’ and 70 non-healers/natives) and interviewed using semi-structured questionnaires, target interviews and group discussion. Some important indices such as the use value index (UV), relative frequency citation (RFC), cultural importance index (CI), and informant consensus factor (F ic ) were calculated for the medicinal plants included in the present study.

Result

It was recorded that the community use a total of 70 species with 64 genera and 35 families for curing various ailments. Family Lamiaceae recorded maximum number of medicinal plants. 21 species used most extensively in traditional health care system. The major parts of the identified plants used for treatment of various ailments were root/rhizome and leaf. The most common methods used for preparation of these plants were decoction and infusion. Ocimum basilicum L., Cannabis sativa L., Citrus aurantifolia (Christm) Sw., Curcuma longa L.and Setaria italic L. had the highest rate of use report. RFC value ranged between 0.03 to 0.91 with highest values for Setaria italica, Zingiber officinale, Ocimum basilicum, and Rephanus sativus . The traditional knowledge is passed verbally to generations and needs to be preserved for the future bio-prospecting of plants that could be a potential cure to any future disease.

Conclusion

In recent years the community has access to modern hospitals and medicinal facilities, although a considerable number still prefer medicinal plants for curing select ailments. It is suggested that these ethnomedicial species need to be screened and evaluated further for their effectiveness for pharmacological activity. Also, significant efforts are required to conserve traditional knowledge and natural habitats of wild medicinal plants.
Health inequity in workers of Latin America and the Caribbean
Authors: Silva-Peñaherrera Michael , Lopez-Ruiz María , Merino-Salazar Pamela , Gómez-García Antonio Ramón , Benavides Fernando G. 
Published: May 2020

Abstract
Background: Latin America and the Caribbean (LAC) is the world’s most inequitable region in terms of wealth distribution. The full scale of social inequalities in health has been hidden by the lack of reliable data. This study aimed to measure and compare health inequalities in the working population within and between 15 countries of LAC. Methods: A sample of 180 163 workers aged 18 years and older was drawn from the most recent national surveys of working conditions or health in 15 LAC countries. Poor self-perceived health (P-SPH) was used as a health indicator, and age, education level, and occupational category as inequality stratifiers. We calculated four measures: absolute and relative population-attributable risks, the Kuznets and weighted Keppel indexes.Results: P-SPH prevalence ranged from 9% in men from Uruguay to 50% in women from Nicaragua. It was higher in women than in men in most countries. A clear gradient was shown, in which young people in non-manual skilled jobs and high education had the lowest prevalence. Nearly 45% of cases that reported P-SPH among men and 35% among women could be avoided if all the groups received a higher level of education. Also, approximately 42% of P-SPH reported by men and 31% by women could be avoided if they all shared the working and employment conditions of non-manual skilled jobs. Conclusions: Wide health inequalities were found between occupational and educational groups in LAC. However, country borders appear to be an even more important stratifier in the production of health inequalities. Urgent interventions to improve worker’s health are needed in countries where prevalence of poor self-perceived health is high. Strengthening occupational health surveillance system in LAC countries should become a priority, in order to track the interventions to reduce occupational health inequity.
The “PPI Hawker”: An innovative method for Patient and Public Involvement (PPI) in health research
Authors: Puerta Lidia Luna , Smith Helen E. 
Published: May 2020

Abstract
Background: Patient and Public Involvement (PPI) in health research entails doing research ‘with’ the public. Successful PPI requires a diversity of patients’ perspectives and experiences. In Singapore, including the public’s voice in research is still in its infancy and different ways of involving the public have to be explored. Our aims were to describe a PPI initiative that enables members of the public to share their ideas and opinions about health research, and to assess the feasibility, accessibility and utility of the initiative. Methods: Building on the concept of the PPI Café used in the west we designed a “PPI Hawker” for Singapore. Here Hawker Centres rather than cafes are used frequently for eating and socialising, providing a one-stop destination for a wide section of society. The PPI facilitators approached people sitting at tables and joined them to discuss questions of relevance to a local research study. Observations and reflexive field notes were used to evaluate the “PPI Hawker’s” feasibility, acceptability and utility in the Singaporean community. Results: In three “PPI Hawkers” we approached 96 people and 72 (75%) engaged in discussions about the design of a population-based research study. The majority (75%) of participants willingly discussed all of the questions posed to them by the researchers, indicating the feasibility of PPI. The PPI participants came from the three major ethnic groups in Singapore and appeared to be broad in age, suggesting “PPI Hawkers” are easily accessible. Both participants and researchers recognised the utility of the “PPI Hawker”, reflecting on people’s willingness to talk about the research issues, engaging in informative conversations and posing relevant questions. Conclusion: The “PPI Hawkers” succeeded in engaging the public in conversations about a local population-based study. The public brought to the researchers’ attention a variety of previously unheard perspectives about the research. Each event fostered connectivity between professionals and the public, generating among researchers a more positive perception of the power of public involvement. “PPI Hawkers” provide an opportunity for co-informed conduct of research studies with diverse members of the public. They create a focus within a community setting for researchers to engage with the public. The resources needed (costs and preparatory time) are relatively few. Not only do “PPI Hawkers” have potential in Singapore, but also for the rest of Asia.
Identifying genetic variants and pathways associated with extreme levels of fetal hemoglobin in Sickle Cell Disease in Tanzania.
Authors: Nkya Siana , Mwita Liberata , Mgaya Josephine , Kumburu Happiness , Zwetselaar Marco van , Menzel Stephan , Mazandu Gaston Kuzamunu , Sangeda Raphael Z. , Chimusa Emile R. , Makani Julie 
Published: May 2020

Abstract
Background: Sickle cell disease (SCD) is a blood disorder caused by a point mutation on the beta globin gene resulting in the synthesis of abnormal hemoglobin. Fetal hemoglobin (HbF) reduces disease severity, but the levels vary from one individual to another. Most research has focused on common variants which differ across populations and hence do not fully account for HbF variation. Methods: We investigated rare and common genetic variants that influence HbF levels in 14 SCD patients to elucidate variants and pathways in SCD patients with extreme HbF levels (≥7.7% for high HbF) and (≤2.5% for low HbF) in Tanzania. We performed targeted next generation sequencing (Illumina_Miseq) covering exonic and other significant fetal hemoglobin-associated loci, including BCL11A, MYB, HOXA9, HBB, HBG1, HBG2, CHD4, KLF1, MBD3, ZBTB7A and PGLYRP1.Results: Results revealed a range of genetic variants, including bi-allelic and multi-allelic SNPs, frameshift insertions and deletions, some of which have functional importance. Notably, there were significantly more deletions in individuals with high HbF levels (11% vs 0.9%). We identified deletions with high HbF levels and frameshift insertions in individuals with low HbF. CHD4 and MBD3 genes, interacting in the same sub-network, were identified to have a significant number of pathogenic or non-synonymous mutations in individuals with low HbF levels, suggesting an important role of epigenetic pathways in the regulation of HbF synthesis. Conclusions: This study provides new insights in selecting essential variants and identifying potential biological pathways associated with extreme HbF levels in SCD using multiple genomic variants associated with HbF in SCD.
Study on the Color-Compensation Effect of Composite Orange-Red Quantum Dots in WLED Application
Authors: Hu Xiaoyue , Xie Yangyang , Geng Chong , Xu Shu , Bi Wengang 
Published: May 2020

Abstract
Quantum dots (QDs) as emerging light-converting materials show the advantage of enhancing color quality of white light-emitting diode (WLED). However, WLEDs employing narrow-emitting monochromic QDs usually present unsatisfactory color rendering in the orange region. Herein, composite orange-red QDs (composite-QDs) are developed through mixing CdSe/ZnS based orange QDs (O-QDs) and red QDs (R-QDs) to compensate the orange-red light for WLEDs. We investigated the effect of self-absorption and fluorescence resonance energy transfer (FRET) process in composite-QDs on the spectral controllability and fluorescent quenching in WLEDs. The concentration and donor/acceptor ratios were also taken into account to analyze the FRET efficiency and help identify suitable composite-QDs for color compensation in the orange-red light region. As the result, the optimized composite-QDs effectively improve the color rendering index of the WLED compared with monochromatic QDs.
Best practice guidelines for management of spinal disorders in skeletal dysplasia
Authors: White Klane , Bober Michael B , Cho Tae-Joon , Goldberg Michael J , Hoover-Fong Julie , Irving Melita , Kamps Shawn , Mackenzie William G , Raggio Cathleen , Spencer Samantha S , Bompadre Viviana , Savarirayan Ravi 
Published: May 2020

Abstract
Background: Disorders of the spine present a common and difficult management concern in patients with skeletal dysplasia. Due to the rarity of these conditions however, the literature, largely consisting of small, single institution case series, is sparse in regard to well-designed studies to support clinical decision making in these situations. Methods: Using the Delphi method, an international, multi-disciplinary group of individuals, with significant experience in the care of patients with skeletal dysplasia, convened to develop multi-disciplinary, “best practice” guidelines in the care of spinal disorders in patients with skeletal dysplasia. Results: Starting with 33 statements, the group a developed a list of 31 “best practice” guidelines. Conclusions: The guidelines are presented and discussed to provide context for clinicians in their decision making in this often-challenging realm of care.
Informing the Development of an E-Platform for Monitoring Wellbeing in Schools: Involving Young People in a Co-Design Process.
Authors: Grant Claire , Widnall Emily , Cross Lauren , Simonoff Emily , Downs Johnny 
Published: May 2020

Abstract
Background: The use of new technologies and methodologies in young people’s mental health research is needed to allow more frequent and reliable sampling. Mobile applications and e-platforms create exciting potential for the collection of large-scale cohort data, however there are various feasibility and ethical issues to consider. Consultation with young people is needed to inform the research agenda, and ensure these technologies are engaging, useful and safe. This article describes the process of Public and Patient Involvement (PPI) with a sample of young people in London, with the aim of i) informing the development of a mood-monitoring e-platform, and ii) providing feedback and advice for researchers developing web-based technologies in the mental health field. Methods: A total of 26 young people were consulted across four advisory group co-design sessions. All young people were students enrolled at one of the participating London based sixth form colleges, and voluntarily attended a workshop session. Audio recordings of the sessions were analysed using a thematic analysis framework. Results: Young people were generally receptive to e-health technologies and valued the opportunity to collaborate throughout the development process. The advisory groups identified key considerations for future web-development work to encourage engagement and prolonged use, including, the promotion of trust and transparency, consideration of accessibility, provision of support, production of engaging and functional design, and acknowledgment of specific contextual influences surrounding young people’s wellbeing. Conclusions: Involving young people in the development process of e-health technologies contributes to optimising the successful adoption and prolonged usage of new methodologies. The thematic map and informant examples can be used to guide researchers interested in developing web-based technologies in the mental health field and will be directly applicable to the development of a mood-monitoring e-platform.