bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterns of patient experience with primary care access in Australia, Canada, New Zealand and Switzerland: a comparative study
Authors: Senn Nicolas , Cohidon Christine , Breton Mylaine , Levesque Jean-Fréderic , Zuchuat Jean-Christophe 
Published: December 2019

Abstract

Objective
Access to primary care (PC) is vital, but complex to define and compare between settings. We aimed to generate a typology of patients’ access patterns across countries using a novel inductive approach.

Design
Cross-sectional surveys.

Setting
Australia, Canada, New Zealand and Switzerland between 2012 and 2014 as part of the QUALICO-PC project.

Participants
Data were collected from 1306 general practices and 10 000+ patients, with nine patients per practice.

Intervention(s)
None.

Main Outcome Measure(s)
Typology of access.

Results
Three axes were retained, explaining 23% of the total variance: (i) ‘temporal and geographical access’; (ii) ‘frequency of access and unmet healthcare needs’; and (iii) ‘affordability and frequency of access’.
Based on the three axes, we identified four clusters of patients: (i) patients reporting overall good access to PC; (ii) frequent users with unmet healthcare needs; (iii) under-users with financial barriers; and (iv) users with poor time/geographical access.
Better access to PC was experienced in Switzerland and New Zealand, while worst access was reported in Canada, where most of the time and geographical barriers were reported. Most financial barriers were observed in Australia and New Zealand. Frequent users with some level of unmet healthcare needs are prevalent in all four countries.

Conclusions
Four main groups of patients with different patterns of access were identified: (i) good access; (ii) geographical and time barriers; (iii) financial barriers; and (iv) frequent users with unmet healthcare needs. Differences in access between the four countries are substantial.
Sensitivity of comorbidity network analysis
Authors: Brunson Jason Cory , Agresta Thomas P , Laubenbacher Reinhard C 
Published: December 2019

Abstract

Objectives
Comorbidity network analysis (CNA) is a graph-theoretic approach to systems medicine based on associations revealed from disease co-occurrence data. Researchers have used CNA to explore epidemiological patterns, differentiate populations, characterize disorders, and more; but these techniques have not been comprehensively evaluated. Our objectives were to assess the stability of common CNA techniques.

Materials and Methods
We obtained seven co-occurrence data sets, most from previous CNAs, coded using several ontologies. We constructed comorbidity networks under various modeling procedures and calculated summary statistics and centrality rankings. We used regression, ordination, and rank correlation to assess these properties’ sensitivity to the source of data and construction parameters.

Results
Most summary statistics were robust to variation in link determination but somewhere sensitive to the association measure. Some more effectively than others discriminated among networks constructed from different data sets. Centrality rankings, especially among hubs, were somewhat sensitive to link determination and highly sensitive to ontology. As multivariate models incorporated additional effects, comorbid associations among low-prevalence disorders weakened while those between high-prevalence disorders shifted negative.

Discussion
Pairwise CNA techniques are generally robust, but some analyses are highly sensitive to certain parameters. Multivariate approaches expose additional conceptual and technical limitations to the usual pairwise approach.

Conclusion
We conclude with a set of recommendations we believe will help CNA researchers improve the robustness of results and the potential of follow-up research.
Co-occurrence of kdr Mutations V1016I and F1534C and Its Association With Phenotypic Resistance to Pyrethroids in Aedes aegypti (Diptera: Culicidae) Populations From Costa Rica
Authors: Zardkoohi Aryana , Castañeda David , Lol Juan C , Castillo Carmen , Lopez Francisco , Marín Rodriguez Rodrigo , Padilla Norma 
Published: December 2019

Abstract
Aedes aegypti (Linnaeus, 1762) is considered the most important mosquito vector species for several arboviruses (e.g., dengue, chikungunya, Zika) in Costa Rica. The primary strategy for the control and prevention of Aedes-borne diseases relies on insecticide-based vector control. However, the emergence of insecticide resistance in the mosquito populations presents a significant threat to these prevention actions. The characterization of the mechanisms driving the insecticide resistance in Ae. aegypti is vital for decision making in vector control programs. Therefore, we analyzed the voltage-gated sodium channel (VGSC) gene for the presence of the V1016I and F1534C kdr mutations in Ae. aegypti populations from Puntarenas and Limon provinces, Costa Rica. The CDC bottle bioassays showed that both Costa Rican Ae. aegypti populations were resistant to permethrin and deltamethrin. In the case of kdr genotyping, results revealed the co-occurrence of V1016I and F1534C mutations in permethrin and deltamethrin-resistant populations, as well as the fixation of the 1534C allele. A strong association between these mutations and permethrin and deltamethrin resistance was found in Puntarenas. Limon did not show this association; however, our results indicate that the Limon population analyzed is not under the same selective pressure as Puntarenas for the VGSC gene. Therefore, our findings make an urgent call to expand the knowledge about the insecticide resistance status and mechanisms in the Costa Rican populations of Ae. aegypti, which must be a priority to develop an effective resistance management plan.
Association Between Outdoor Air Pollution and Risk of Malignant and Benign Brain Tumors: The Multiethnic Cohort Study
Authors: Wu Anna H , Wu Jun , Tseng Chiuchen , Yang Juan , Shariff-Marco Salma , Fruin Scott , Larson Timothy , Setiawan Veronica W , Masri Shahir , Porcel Jacqueline , Jain Jennifer , Chen Thomas C , Stram Daniel O , Marchand Loïc Le , Ritz Beate , Cheng Iona 
Published: December 2019

Abstract

Background
There are increasing concerns about the potential impact of air pollution on chronic brain inflammation and microglia cell activation, but evidence of its carcinogenic effects is limited.

Methods
We used kriging interpolation and land use regression models to estimate long-term air pollutant exposures of oxides of nitrogen (NOx, NO2), kriging interpolation for ozone (O3), carbon monoxide, and particulate matter (PM2.5, PM10), and nearest monitoring station measurements for benzene for 103 308 men and women from the Multiethnic Cohort, residing largely in Los Angeles County from recruitment (1993–1996) through 2013. We used Cox proportional hazards models to examine the associations between time-varying pollutants and risk of malignant brain cancer (94 men, 116 women) and meningioma (130 men, 425 women) with adjustment for sex, race and ethnicity, neighborhood socioeconomic status, smoking, occupation, and other covariates. Stratified analyses were conducted by sex and race and ethnicity.

Results
Brain cancer risk in men increased in association with exposure to benzene (hazard ratio [HR] = 3.52, 95% confidence interval [CI] = 1.55 to 7.55) and PM10 (HR = 1.80, 95% CI = 1.00 to 3.23). Stronger associations with PM10 (HR = 3.02, 95% CI = 1.26 to 7.23), O3 (HR = 2.93, 95% CI = 1.09 to 7.88), and benzene (HR = 4.06, 95% CI = 1.17 to 18.2) were observed among Latino men. Air pollution was unrelated to risk of meningioma except that O3 exposure was associated with risk in men (HR = 1.77, 95% CI = 1.02 to 3.06). Brain cancer risk in women was unrelated to air pollution exposures.

Conclusions
Confirmation of these sex differences in air pollution–brain cancer associations and the stronger findings in Latino men in additional diverse populations is warranted.
China’s International Commercial Court: Background, Obstacles and the Road Ahead
Authors: Zhang Sheng 
Published: December 2019

Abstract
The establishments of international commercial courts reflect the closer alignment of commercial transactions and the development of dispute resolution mechanisms. To mainly facilitate the developments of the ‘Belt and Road Initiative’, China established the China international commercial court (CICC) in 2018. It marked a significant step in the development of China’s judicial system. However, compared with other international commercial courts in the world, the construction of the CICC still has much room for improvement in the areas of jurisdiction, internationalization, and the recognition and enforcement of judgments. The China’s Supreme People’s Court (SPC) needs to consider how to refine the working procedures, enhance the internationalization, and promote the recognition and enforcement of the awards by the CICC. The SPC may need to update the current legal regime for the CICC based on the operation and the experience of trials. In addition to the efforts of the SPC to pave the way for developments, China needs to consider modifying the relevant rules and actively expand its judicial cooperation with other countries.
Low temperature synergistically promotes wounding-induced indole accumulation by INDUCER OF CBF EXPRESSION-mediated alterations of jasmonic acid signaling in Camellia sinensis
Authors: Zhou Ying , Zeng Lanting , Hou Xingliang , Liao Yinyin , Yang Ziyin 
Published: December 2019

AbstractPlants have to cope with various environmental stress factors which significantly impact plant physiology and secondary metabolism. Individual stresses, such as low temperature, are known to activate plant volatile compounds as a defense. However, less is known about the effect of multiple stresses on plant volatile formation. Here, the effect of dual stresses (wounding and low temperature) on volatile compounds in tea (Camellia sinensis) plants and the underlying signalling mechanisms were investigated. Indole, an insect resistance volatile, was maintained at a higher content and for a longer time under dual stresses compared with wounding alone. CsMYC2a, a jasmonate (JA)-responsive transcription factor, was the major regulator of CsTSB2, a gene encoding a tryptophan synthase β-subunit essential for indole synthesis. During the recovery phase after tea wounding, low temperature helped to maintain a higher JA level. Further study showed that CsICE2 interacted directly with CsJAZ2 to relieve inhibition of CsMYC2a, thereby promoting JA biosynthesis and downstream expression of the responsive gene CsTSB2 ultimately enhancing indole biosynthesis. These findings shed light on the role of low temperature in promoting plant damage responses and advance knowledge of the molecular mechanisms by which multiple stresses coordinately regulate plant responses to the biotic and abiotic environment.
Regulation of accretion by its outflow in a symbiotic star: the 2016 outflow fast state of MWC 560
Authors: Lucy Adrian B , Sokoloski J L , Munari U , Roy Nirupam , Kuin N Paul M , Rupen Michael P , Knigge Christian , Darnley M J , Luna G J M , Somogyi Péter , Valisa P , Milani A , Sollecchia U , Weston Jennifer H S 
Published: December 2019

ABSTRACT
How are accretion discs affected by their outflows? To address this question for white dwarfs accreting from cool giants, we performed optical, radio, X-ray, and ultraviolet observations of the outflow-driving symbiotic star MWC 560 (≡V694 Mon) during its 2016 optical high state. We tracked multi-wavelength changes that signalled an abrupt increase in outflow power at the initiation of a months-long outflow fast state, just as the optical flux peaked: (1) an abrupt doubling of Balmer absorption velocities; (2) the onset of a 20 μJy per month increase in radio flux; and (3) an order-of-magnitude increase in soft X-ray flux. Juxtaposing to prior X-ray observations and their coeval optical spectra, we infer that both high-velocity and low-velocity optical outflow components must be simultaneously present to yield a large soft X-ray flux, which may originate in shocks where these fast and slow absorbers collide. Our optical and ultraviolet spectra indicate that the broad absorption-line gas was fast, stable, and dense (≳106.5  cm−3) throughout the 2016 outflow fast state, steadily feeding a lower density (≲105.5 cm−3) region of radio-emitting gas. Persistent optical and ultraviolet flickering indicate that the accretion disc remained intact. The stability of these properties in 2016 contrasts to their instability during MWC 560’s 1990 outburst, even though the disc reached a similar accretion rate. We propose that the self-regulatory effect of a steady fast outflow from the disc in 2016 prevented a catastrophic ejection of the inner disc. This behaviour in a symbiotic binary resembles disc/outflow relationships governing accretion state changes in X-ray binaries.
Characterization of unresolved and unclassified sources detected in radio continuum surveys of the Galactic plane
Authors: Chakraborty Arnab , Roy Nirupam , Wang Y , Datta Abhirup , Beuther H , Medina S-N X , Menten K M , Urquhart J S , Brunthaler A , Dzib S A 
Published: December 2019

ABSTRACT
The continuum emission from 1 to 2 GHz of The H i/OH/Recombination line survey of the inner Milky Way (THOR) at ≲18 arcsec resolution covers ∼132 deg2 of the Galactic plane and detects 10 387 sources. Similarly, the first data release of the Global View of Star Formation in the Milky Way (GLOSTAR) survey covers ∼16 deg2 of the Galactic plane from 4 to 8 GHz at 18 arcsec resolution and detects 1575 sources. However, a large fraction of the unresolved discrete sources detected in these radio continuum surveys of the Galactic plane remain unclassified. Here, we study the Euclidean-normalized differential source counts of unclassified and unresolved sources detected in these surveys and compare them with simulated extragalactic radio source populations and previously established source counts. We find that the differential source counts for THOR and GLOSTAR surveys are in excellent agreement with both simulation and previous observations. We also estimate the angular two-point correlation function of unclassified and unresolved sources detected in THOR survey. We find a higher clustering amplitude in comparison with the Faint Images of the Radio Sky at Twenty-cm (FIRST) survey up to the angular separation of 5°. The decrease in angular correlation with increasing flux cut and the excellent agreement of clustering pattern of sources above 1 mJy with high-z samples (z &gt; 0.5) of the FIRST survey indicates that these sources might be high-z extragalactic compact objects. The similar pattern of one-point and two-point statistics of unclassified and compact sources with extragalactic surveys and simulations confirms the extragalactic origin of these sources.
NVST observations of collision-induced apparent fan-shaped jets
Authors: Li Ting , Hou Yijun , Zhang Jun , Xiang Yongyuan 
Published: December 2019

ABSTRACT
Using high-quality H α observations from the New Vacuum Solar Telescope, we first report apparent fan-shaped jets (AFJs) generated during the interaction between primary fan-shaped jets (FJs) and nearby facula magnetic structure. The primary FJs were intermittently launched from a sunspot penumbra with negative-polarity magnetic fields in active region 12740 on 2019 May 6, accompanied by impulsive brightenings at the base. While the propagating FJ encountered and collided with the negative-polarity magnetic structure of the west facula, the density of jet material was enhanced to the east of the facula. Meanwhile, the jet structures exhibited a deflection towards the north-west at the jet–facula collision location. Then the primary FJ evolved into two parts, with one part being reflected away from the facula and the other part forming an AFJ. Easily distinguished from the primary FJ, the ejecting AFJ was more ordered and had an apparent end at the facula. The AFJ was impulsively accelerated to speeds of 100 km s−1, and reached lengths of up to 40 Mm. The observed AFJ had a similar morphology to the fan-shaped quasi-separatrix layer (QSL) between the penumbra and facula magnetic systems, implying that the material of the AFJ was mainly guided by the fan plane of the QSL. We suggest that the collision does not cause a change in the field-line connectivity and only leads to the redistribution of jet material.
Finding singularities in gravitational lensing
Authors: Meena Ashish Kumar , Bagla J S 
Published: December 2019

ABSTRACT
The number of strong lens systems is expected to increase significantly in ongoing and upcoming surveys. With an increase in the total number of such systems, we expect to discover many configurations that correspond to unstable caustics. In such cases, the instability can be used to our advantage for constraining the lens model. We have implemented algorithms for detection of different types of singularities in gravitational lensing. We apply our approach on a variety of lens models and then go on to test it with the inferred mass distribution for Abell 697 as an example application. We propose to represent lenses using A3-lines and singular points (A4 and D4) in the image plane. We propose this as a compact representation of complex lens systems that can capture all the details in a single snapshot.
Difficulties in mid-infrared selection of AGNs in dwarf galaxies
Authors: Lupi Alessandro , Sbarrato Tullia , Carniani Stefano 
Published: December 2019

ABSTRACT
While massive black holes (MBHs) are known to inhabit all massive galaxies, their ubiquitous presence in dwarf galaxies has not been confirmed yet, with only a limited number of sources detected so far. Recently, some studies proposed infrared emission as an alternative way to identify MBHs in dwarfs, based on a similar approach usually applied to quasars. In this study, by accurately combining optical and infrared data taking into account resolution effects and source overlapping, we investigate in detail the possible limitations of this approach with current ground-based facilities, finding a quite low (∼0.4 per cent) fraction of active MBH in dwarfs that are luminous in mid-infrared, consistent with several previous results. Our results suggest that the infrared selection is strongly affected by several limitations that make the identification of MBHs in dwarf galaxies currently prohibitive, especially because of the very poor resolution compared to optical surveys, and the likely contamination by nearby sources, although we find a few good candidates worth further follow-ups. Optical, X-ray, and radio observations therefore still represent the most secure way to search for MBH in dwarfs.
Potassium channels as potential drug targets for limb wound repair and regeneration
Authors: Zhang Wengeng , Das Pragnya , Kelangi Sarah , Bei Marianna 
Published: December 2019

Abstract

Background
Ion channels are a large family of transmembrane proteins, accessible by soluble membrane-impermeable molecules, and thus are targets for development of therapeutic drugs. Ion channels are the second most common target for existing drugs, after G protein-coupled receptors, and are expected to make a big impact on precision medicine in many different diseases including wound repair and regeneration. Research has shown that endogenous bioelectric signaling mediated by ion channels is critical in non-mammalian limb regeneration. However, the role of ion channels in regeneration of limbs in mammalian systems is not yet defined.

Methods
To explore the role of potassium channels in limb wound repair and regeneration, the hindlimbs of mouse embryos were amputated at E12.5 when the wound is expected to regenerate and E15.5 when the wound is not expected to regenerate, and gene expression of potassium channels was studied.

Results
Most of the potassium channels were downregulated, except for the potassium channel kcnj8 (Kir6.1) which was upregulated in E12.5 embryos after amputation.

Conclusion
This study provides a new mouse limb regeneration model and demonstrates that potassium channels are potential drug targets for limb wound healing and regeneration.
PHOTON FIELD OF ~100–200 KEV FOR ENVIRONMENTAL DOSEMETER CALIBRATION
Authors: Tajudin S M , Namito Y , Sanami T , Hirayama H 
Published: December 2019

Abstract
As a reference photon field, several radionuclides have been used frequently, such as 241Am,137Cs and60 Co for calibration. These nuclides provide mono-energy photons for dosemeters covering few tens of keV–MeV. The main energy around 200 keV is important for both environmental and medical fields since the former should consider scattering photons and the later should measure photons from X-ray generator. In our previous work, a backscattered layout can provide a uniform photon field spectra and dose rate with an energy of 190 keV by using an affordable intensity 137 Cs gamma source. Several other quasi-monoenergetic photon fields in the range of 100–200 keV could be obtained by using several available gamma sources. Two calibrated environmental CsI(Tl) survey meters, Horiba PA-1000 and Mr. Gamma A2700, had been measured with the developed backscattered photon field to understand energy-dependent features in order to confirm dosemeter readings. Consequently, both scintillator instruments are sensitive for measurements of the relatively low dose rates at 190 keV.
PROMIS PF in the Evaluation of Postoperative Outcomes in Workers’ Compensation Patients Following Anterior Cervical Discectomy and Fusion
Authors: Yoo Joon S. , Parrish James M. , Jenkins Nathaniel W. , Brundage Thomas S. , Hrynewycz Nadia M. , Patel Dillon S. , Singh Kern 
Published: December 2019

Study Design:
This was a retrospective cohort study.

Objective:
To determine the improvement of clinical outcomes in Workers’ Compensation (WC) patients compared with non-WC patients utilizing Patient-reported Outcome Measurement Information System Physical Function (PROMIS PF) following anterior cervical discectomy and fusion (ACDF).

Summary of Background Data:
To our knowledge, there has not been a study to evaluate clinical outcomes of WC patients utilizing the PROMIS PF survey.

Methods and Materials:
Patients undergoing a primary, 1 to 3-level ACDF were retrospectively reviewed and stratified according to insurance (WC and non-WC). Demographic and perioperative characteristics were compared using χ2 test and independent t tests. Change in PROMIS PF scores was calculated using paired t tests. Differences in postoperative PROMIS PF scores and changes in PROMIS PF from baseline were compared using linear regression.

Results:
In total, 124 1 to 3-level ACDF patients were included: 36 had WC insurance and 88 had non-WC insurance. WC patients were younger and more likely to be obese. WC patients reported significantly lower PROMIS PF scores preoperatively and at 6 weeks, 12 weeks, and 6 months timepoints. However, both cohorts reported comparable PROMIS PF scores at the 1-year timepoint. WC patients demonstrated similar improvements from baseline through 1-year postoperatively compared with non-WC patients. For both non-WC and WC cohort, the change in the postoperative PROMIS PF score from baseline was significant at 3 months, 6 months, and 1 year. However, in both cohorts, the change in the postoperative PROMIS PF score from baseline was not significantly different at 6 weeks.

Conclusions:
In our study, WC patients had worse baseline physical function as indicated by lower preoperative PROMIS PF scores and reported lower PROMIS PF scores postoperatively. However, there were no significant differences when comparing the postoperative change from baseline between the cohorts. Both cohorts experienced significant postoperative improvements from baseline. This study established that PROMIS PF is an effective tool to evaluate recovery of WC patients following ACDF.