bluuebunny/crossref_metadata_2025_split huggingface dataset:
FABP7 Regulates Acetyl-CoA Metabolism Through the Interaction with ACLY in the Nucleus of Astrocytes
Authors: Kagawa Yoshiteru , Umaru Banlanjo Abdulaziz , Shima Hiroki , Ito Ryo , Zama Ryo , Islam Ariful , Kanno Shin-ichiro , Yasui Akira , Sato Shun , Jozaki Kosuke , Shil Subrata Kumar , Miyazaki Hirofumi , Kobayashi Shuhei , Yamamoto Yui , Kogo Hiroshi , Shimamoto-Mitsuyama Chie , Sugawara Akira , Sugino Norihiro , Kanamori Masayuki , Tominaga Teiji , Yoshikawa Takeo , Fukunaga Kohji , Igarashi Kazuhiko , Owada Yuji 
Published: August 2020

AbstractFatty acid binding protein 7 (FABP7) is an intracellular fatty acid chaperon that is highly expressed in astrocytes, oligodendrocyte-precursor cells, and malignant glioma. Previously, we reported that FABP7 regulates the response to extracellular stimuli by controlling the expression of caveolin-1, an important component of lipid raft. Here, we explored the detailed mechanisms underlying FABP7 regulation of caveolin-1 expression using primary cultured FABP7-KO astrocytes as a model of loss of function and NIH-3T3 cells as a model of gain of function. We discovered that FABP7 interacts with ATP-citrate lyase (ACLY) and is important for acetyl-CoA metabolism in the nucleus. This interaction leads to epigenetic regulation of several genes, including caveolin-1. Our novel findings suggest that FABP7-ACLY modulation of nuclear acetyl-CoA has more influence on histone acetylation than cytoplasmic acetyl-CoA. The changes to histone structure may modify caveolae-related cell activity in astrocytes and tumors, including malignant glioma.
The state of the art in scale inhibitor squeeze treatment
Authors: Kan Amy T. , Dai Zhaoyi , Tomson Mason B. 
Published: August 2020

AbstractThe mechanistic understanding of the reactions that govern the inhibitor retention and release, modeling, and the state-of-the-art innovation in squeeze treatment are reviewed. The retention and release are governed by (1) the amount of calcite that can dissolve prior to inhibitor-induced surface poisoning; (2) calcite surface poisoning after ~ 20 molecular layers of surface coverage by the adsorbed inhibitors to retard further calcite dissolution; (3) less base,$${\text{CO}}_{3}^{2 - }$$CO32-, is released into the aqueous solution; (4) formation of the more acidic inhibitor precipitates; (5) phase transformation and maturation of the more acidic inhibitor precipitates; and (6) dissolution of the less soluble crystalline inhibitor precipitates. The trend to advance squeeze technologies is through (1) enhancing scale inhibitor retention, (2) optimizing the delivery of scale inhibitors to the target zone, and (3) improving monitoring methods. Lastly, a prototype yardstick for measuring the squeeze performance is used to compare the squeeze life of 17 actual squeeze treatments. Even though the various squeeze treatments appear to be different, all published squeeze durations can be rated based on the normalized squeeze life per unit mass of inhibitors.
Plant iconography and its message: realism and symbolic message in the Bernini fountain of the four rivers in Rome
Authors: Caneva G. , Altieri A. , Kumbaric A. , Bartoli F. 
Published: August 2020

AbstractThe use of symbols in architecture of the past centuries is evident, even if sometimes cryptic. The reasons behind the representation of plants in artistic and architectural contexts are of great interest as they help in their understanding. We analysed the plants carved in the Fountain of Four Rivers (Rome), designed by G.L. Bernini (mid-seventeenth century), through iconographic and historical documents. The carved plants (about 34 species) creates a natural and symbolic association with the selected rivers and continents. Some species are chosen to characterise various geographic contexts or fluvial and rupestrian habitats or are referred to the papal coats of arms (Innocent X Pamphilj). A certain number has auspicious connotation and takes a strong symbolic salvific meaning and protective against the evil’s threat. The Kircherian influence emerges in several iconographic choices, as well as the river selection and orientation, in a philosophical-religious logic linked to the Papacy and Christianity role.
Multi-modal Approach for Benthic Impact Assessments in Moraine Habitats: a Case Study at the Block Island Wind Farm
Authors: Guarinello Marisa L. , Carey Drew A. 
Published: August 2020

AbstractBenthic assessment techniques utilized in soft sediment areas are of limited utility in glacial moraine habitats that are structurally complex and largely composed of hard substrata. We present a multi-modal approach consisting of multibeam bathymetry, video, and still imagery that collectively provides the knowledge base necessary to perform impact assessments in these habitats. Baseline and post-construction surveys were conducted adjacent to the Block Island Wind Farm to develop and test these methodologies within the context of offshore wind development, specifically for detecting and documenting anchoring-related impacts to moraine habitats. Habitat data were evaluated using the substrate and biotic components of the national classification standard, the Coastal and Marine Ecological Classification Standard, recommended by federal regulators, with modifications to present results in terms of predicted vulnerability to disturbance. Habitats near the wind farm were diverse and patchy, ranging from rippled gravelly sand to continuous cobble/boulder fields with high biotic cover. Anchor furrows were detected in moderate value habitats in bathymetric and video data. The multi-modal survey approach tested at the Block Island Wind Farm and presented here is now specifically recommended by federal agencies and is being used to inform efforts currently underway to map and assess benthic habitats for a number of U.S. projects seeking federal permits.
Altered Cerebrospinal Fluid (CSF) in Children with Ataxia Telangiectasia
Authors: Woelke S. , Schrewe R. , Donath H. , Theis M. , Kieslich M. , Duecker R. , Auburger G. , Schubert R. , Zielen S. 
Published: August 2020

AbstractAtaxia telangiectasia (A-T) is a devastating multi-system disorder characterized by progressive cerebellar ataxia and immunodeficiency. The neurological decline may be caused by multiple factors of which ongoing inflammation and oxidative stress may play a dominant role. The objective of the present investigation was to determine cerebrospinal fluid (CSF) proteins and possible low-grade inflammation and its relation to age and neurological deterioration. In the present study, we investigated 15 patients with A-T from 2 to 16 years. Our investigation included blood and CSF tests, clinical neurological examination, A-T score, and MRI findings. The albumin ratio (AR) was analyzed to determine the blood–brain-barrier function. In addition, inflammatory cytokines (IL-1α, IL-6, IL-8, IL-12 p40, IL-17A, IFN-γ, TNF-α) were measured by the multiplex cytometric bead array. We compared the results with those from an age-matched control group. Three of the A-T patients were analyzed separately (one after resection of a cerebral meningioma, one after radiation and chemotherapy due to leukemia, one after stem cell transplantation). Patient had significantly more moderate and severe side effects due to CSF puncture (vomiting, headache, need for anti-emetic drugs) compared with healthy controls. Total protein, albumin, and the AR increased with age indicating a disturbed blood barrier function in older children. There were no differences for cytokines in serum and CSF with the exception of IL-2, which was significantly higher in controls in serum. The AR is significantly altered in A-T patients, but low-grade inflammation is not detectable in serum and CSF.
Self-compassion and Perceived Criticism in Adults with Attention Deficit Hyperactivity Disorder (ADHD)
Authors: Beaton Danielle M. , Sirois Fuschia , Milne Elizabeth 
Published: August 2020

Abstract
Objectives
Attention deficit hyperactivity disorder (ADHD) is associated with increased criticism from others. To date, there is little research considering the consequences of how others respond to people with ADHD. Self-compassion is a positive way of relating to oneself during difficulty. Here, we investigate whether levels of self-compassion differ between people with and without ADHD, and whether perceived criticism mediates any differences in self-compassion between people with and without ADHD.

Methods
A cross-sectional design was used to conduct natural group comparisons. A sample of 1203 adults (46% with a self-reported ADHD diagnosis) recruited via social media, online forums and posters completed online self-report measures of diagnostic status, ADHD traits, self-compassion and perceived criticism. Between-group comparisons of self-compassion and perceived criticism were conducted on participants grouped by diagnosis, then grouped by ADHD trait severity. Perceived criticism was tested as a mediator variable between ADHD diagnosis and self-compassion.

Results
Adults with an ADHD diagnosis showed significantly lower self-compassion and higher perceived criticism than the participants without ADHD. Participants high in ADHD traits but without a diagnosis had significantly similar levels of self-compassion to the diagnosed group. Mediation analysis found that higher perceived criticism partially explained the relationship between ADHD diagnosis and self-compassion, even after accounting for co-occurring mood disorder diagnosis.

Conclusions
Adults with ADHD are less self-compassionate than adults without ADHD. This is partially explained by the higher level of criticism they perceive from others.
Formulation of cellulose using groundnut husk as an environment-friendly fluid loss retarder additive and rheological modifier comparable to PAC for WBM
Authors: Patidar Atul Kumar , Sharma Anjali , Joshi Dev 
Published: August 2020

AbstractThe hydrocarbon extraction and exploitation using state-of-the-art modern drilling technologies urge the use of biodegradable, environment-friendly drilling fluid and drilling fluid additives to protect the environment and humanity. As more environmental laws are enacted and new safety rules implemented to oust the usage of toxic chemicals as fluid additives, it becomes inevitable that we re-evaluate our choice of drilling fluid additives. Drilling fluids and its additives play a crucial role in drilling operations as well as project costing; hence, it is needed that we develop cost-effective environment-friendly drilling fluid additives that meet the requirements for smooth functioning in geologically complex scenarios as well as have a minimal ecological impact. The current research work demonstrates key outcomes of investigations carried out on the formulation of a sustainable drilling fluid system, where groundnut husk is used as a fluid loss additive and a rheological modifier having no toxicity and high biodegradability. Cellulose was generated from groundnut husk at two varying particle sizes using mesh analysis, which was then compared with the commercially available PAC at different concentrations to validate its properties as a comparable fluid loss retarder additive as well as a rheological modifier. In the present work, various controlling characteristics of proposed groundnut husk additive are discussed, where comparison at different concentrations with a commercially available additive, PAC, is also validated. The API filtration losses demonstrated by the (63–74) µm and the (250–297) µm proposed additive showed a decrease of 91.88% and 82.31%, respectively, from the base mud at 4% concentration. The proposed husk additives acted as a filtrate retarder additive without much deviation from base rheology and with considerably higher pH than the base mud. This investigation indicates that the proposed fluid loss additive and rheological modifier can minimize the environmental hazards and have proved to be a cost-effective eco-friendly alternative in this challenging phase of the hydrocarbon exploration industry.
Endobronchial Treatment of Bronchial Carcinoid in the Elderly
Authors: Daniels Johannes M. A. , Reuling Ellen M. B. P. , Dickhoff C. 
Published: August 2020

AbstractPurpose of the ReviewAlthough surgical resection is considered the gold standard of curative treatment for bronchial carcinoid, endobronchial treatment (EBT) can serve as a less invasive curative or palliative treatment in a selection of patients. It is unclear whether elderly patients with bronchial carcinoid should be treated in the same way as younger patients. In order to study the characteristics and treatment of elderly patients with bronchial carcinoid, we analyzed data from a cohort of patients that have been treated for bronchial carcinoid with EBT, surgical resection, or a combination of both. We used our existing database of patients referred for EBT and defined two groups of patients: ≥ 65 and < 65 years. We compared the characteristics, treatment, and causes of death between these groups. Successful EBT was defined as definitive treatment without signs of recurrence during follow-up with CT and bronchoscopy.Recent FindingsThirty-five patients (19%) were ≥ 65 years. The incidence of atypical carcinoid was the same in both age groups (31%). Thirty-six of 184 patients (20%) were directly referred for surgical resection and 148 (80%) underwent EBT. There was no significant difference in success of EBT between patients <65 years (58/122, 48%) and patients ≥ 65 years (15/26, 58%) (p = 0.347). Complication rates were similar in both groups. After unsuccessful EBT, only 70% (14/20) of the elderly patients was operated, whereas 93% (85/91) of the patients < 65 years was operated (p = 0.001). Disease specific mortality was 6% (2/35) in the group ≥ 65 years and 2% (3/149) in the group < 65 years.SummaryThe incidence of atypical carcinoid is similar between the elderly and younger patients. Success rate and complication rate of EBT do not differ significantly between the age groups. After unsuccessful EBT, elderly patients were less likely to undergo surgical resection, which does not seem associated with excess disease specific mortality, although the number of events in this study is low.
Conflicts Between Trade Mark Rights and Freedom of Expression Under EU Trade Mark Law: Reality or Illusion?
Authors: Bohaczewski Michal 
Published: August 2020

AbstractThe issue of reconciling trade mark rights and freedom of expression is a classic question discussed by European scholars which has recently been reopened because of the express reference to “fundamental rights and freedoms, and in particular the freedom of expression” in the preambles of Directive 2015/2436 and of Regulation 2017/1001. In this article, the author argues that, in the light of the EU legislation, conflicts between the freedom of expression and trade mark rights are often illusory. Indeed, in this debate we focus too quickly on the question of resolving a potential conflict, while EU trade mark law itself provides for limits that guarantee respect of the freedom of expression. It should also be borne in mind that commercial expressions enjoy a more restricted freedom since they serve private economic interests and not the interests of society as a whole. The freedom of commercial expression therefore needs to be limited by trade mark rights which are also fundamental rights, having equivalent value. Consequently, it seems unnecessary to envisage use related to the freedom of expression, of a sign reproducing or imitating a trade mark, as a specific limitation of trade mark rights, either in the speciality or in the field of enhanced protection of trade marks with a reputation.
Managing endpoints, the weakest link in the security chain
Authors: Waterson Dave 
Published: August 2020

Endpoint security is a term open to interpretation. Traditionally, an endpoint would be any device or node connected to the LAN or WAN, such as a workstation or end-user PC, or a modem, a hub or a switch. But now endpoints incorporate a multitude of additional digital devices from laptops, tablets and mobile phones, which sit on the edge of the network, through to network printers, consumer and industrial IoT devices and point-of-sale systems. Endpoints include a multitude of additional digital devices from laptops, tablets and mobile phones through to network printers, IoT devices and point-of-sale systems. Securing this ever-expanding portfolio of endpoint technology has become an urgent necessity, not least because these devices represent a significant risk to the cloud ecosystem. By securing the input of sensitive data and by wrapping security around the applications that handle sensitive data, organisations can add another layer, boosting the protection of endpoint devices, explains Dave Waterson of SentryBay.
The Access Technology Program of the Indiana Clinical Translational Sciences Institute (CTSI): A model to facilitate access to cutting-edge technologies across a state
Authors: Orschell Christie M. , Skaar Todd C. , DeFord Melanie E. , Ybe Joel , Driscol Julie , Drury Christine , Reeves Lilith , Willis Monte S. , Reiter Jill L. , York Jenna , Orr Rob , McClintick Jeanette N. , Sors Thomas G. , Hunt Joe , Cornetta Kenneth , Shekhar Anantha 
Published: August 2020

Abstract

Introduction:
Access to cutting-edge technologies is essential for investigators to advance translational research. The Indiana Clinical and Translational Sciences Institute (CTSI) spans three major and preeminent universities, four large academic campuses across the state of Indiana, and is mandate to provide best practices to a whole state.

Methods:
To address the need to facilitate the availability of innovative technologies to its investigators, the Indiana CTSI implemented the Access Technology Program (ATP). The activities of the ATP, or any program of the Indiana CTSI, are challenged to connect technologies and investigators on the multiple Indiana CTSI campuses by the geographical distances between campuses (1–4 hr driving time).

Results:
Herein, we describe the initiatives developed by the ATP to increase the availability of state-of-the-art technologies to its investigators on all Indiana CTSI campuses, and the methods developed by the ATP to bridge the distance between campuses, technologies, and investigators for the advancement of clinical translational research.

Conclusions:
The methods and practices described in this publication may inform other approaches to enhance translational research, dissemination, and usage of innovative technologies by translational investigators, especially when distance or multi-campus cultural differences are factors to efficient application.
Evaluation of an exercise physiology service in a youth mental health service
Authors: Pearce M. , Foote L. , Brown E. , O’Donoghue B. 
Published: August 2020

BackgroundIndividuals who experience serious mental health disorders are at an increased risk of physical illness co-morbidity and early intervention is crucial. Recommendations to embed an exercise physiologist service into a mental health service have not been fully evaluated.ObjectivesThis study aimed to determine (i) demographics and clinical characteristics of the young people referred to exercise physiology, (ii) adherence to metabolic monitoring, (iii) baseline physical health and (iv) level of engagement after referral.MethodsThis is a naturalistic cohort study and included all young people referred to the exercise physiology service between 2015 and 2019 at Orygen, a specialist youth mental health service in the north-western region of Melbourne.ResultsDuring the study period of 45 months, 312 young people were referred to exercise physiology, and of those, 51.3% were male. The mean age was 19.8 years. In regard to primary diagnoses, 47.4% had a psychotic disorder and 33.7% an affective disorder. Baseline weight measurements were completed for 71.8% of young people. The proportion of young people who were classified as overweight or obese increased from 55.1% to 70.4% (p< 0.001). For those referred, 61.5% attended either an individual session or a group session. A total of 29.5% did not attend their appointment following referral.ConclusionsAs over half of young people had poor physical health at presentation, integrating an exercise physiology service into a youth mental health service is a novel and needed intervention. However, there still needs to be an emphasis on metabolic monitoring and engagement.
ASSESSING THE STRATIGRAPHIC INTEGRITY OF PLANKTIC AND BENTHIC 14C RECORDS IN THE WESTERN PACIFIC FOR Δ14C RECONSTRUCTIONS AT THE LAST GLACIAL TERMINATION
Authors: Stott Lowell D 
Published: August 2020

ABSTRACTThere is a growing database of radiocarbon (14C) reconstructions from biogenic carbonate taken from marine sediment cores being used to investigate changing ocean circulation and carbon cycling at the end of the last great ice age. Reported here are 14C results from a marine core taken in the Makassar Straits of the western equatorial Pacific that was intended to test whether there was evidence of geologic carbon release to the ocean during the glacial termination. A thorough investigation of planktic and benthic 14C ages with stable isotopes and CT-scans revealed extensive burrowing in the upper 2 m of the core that displaced younger sediments downward by more than half a meter into the glacial section of the core. The vertical displacement is evident in both planktic and benthic fossils. However, the extent of displacement and the stratigraphic disturbance became evident only after multiple measurements of different species and genera. A CT-scan prior to sampling would be an effective screening tool to avoid sampling problem cores such as this.
DATING OF REMAINS OF THE MEDIEVAL CHURCH SANTA MARIA DI CAMPOGROSSO IN SICILY IN THE LIGHT OF MULTIDISCIPLINARY STUDIES
Authors: Krąpiec Marek , Moździoch Sławomir , Moździoch Ewa 
Published: August 2020

ABSTRACTExcavations of the remains of the medieval church of Santa Maria di Campogrosso (Sicily) were conducted by the Institute of Archaeology and Ethnology of the Polish Academy of Sciences as part of scientific cooperation with Soprintendenza per i Beni Culturali ed Ambientali di Palermo. Based on the records of post-medieval historians, the construction of the church was placed in the second half of the 11th century, which contradicts the findings of architectural historians, who dated the building to the 13th-century and even later. As a result of archaeological excavations carried out in 2015–2018, it was possible to locate unknown fragments of the church’s structure and the remains of the cemetery adjacent to it. The 14C dating carried out for samples obtained from the walls of the existing building as well as from bone remains from the churchyard in combination with stratigraphic information from archaeological trenches and the chronology of coins indicates a high probability of the church construction in the second half of the 12th century and confirms the end of the monastery complex existence at the end of the 13th century.