bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intellectual capital based reputation for market internationalization
Authors: Ulubeyli Serdar , Yorulmaz Dilek 
Published: November 2019

PurposeThe purpose of this paper is to report the possible impact of intellectual capital (IC) on firm reputation (FR) and investigates if there is a relationship between FR and market internationalization (MI).Design/methodology/approachThe data were collected from engineering consultancy firms (ECFs) in Turkey. The study employed structural equation modeling to examine the hypothesized relationships between IC, FR, and MI of ECFs.FindingsECFs with strong human and structural capital can have a good FR. However, healthy relational capital may not lead to the same effect on FR. On the contrary, FR can create high-quality relational capital for ECFs. Lastly, a good FR, based on robust human and structural capital, can provide the success of ECFs’ MI process.Research limitations/implicationsThis model may be analyzed for other knowledge-intensive business services. Also, subsequent researches may investigate potential variations in results about other sectors and geographical areas. Moreover, various constructs may be included in the model. However, a greater number of samples could lead to distinctive outcomes.Practical implicationsThe research may be a general guide for related professionals and their companies to build long-term strategies, given IC, FR and MI. In this respect, they should take into account human and structural capital for MI.Social implicationsECFs that can be active in the international arena may maintain their services by financial sustainability. Thus, the advantage may result in a prosperous society.Originality/valueThe study is first to suggest a model joining IC and FR for the MI process of ECFs. This is suitable for competition of ECFs that are willing to be sustainable firms.
Does postgraduate degree make any difference in job performance of information professionals?
Authors: Hashmi Farhana , Ameen Kanwal , Soroya Saira 
Published: November 2019

Purpose
Since 2005, various public and private sector institutions have been offering a postgraduate degree in Library and Information Management (LIM) in Pakistan and a good number of professionals working in different sectors have got MPhil degree. However, locally, no study has been conducted to measure the impact of higher education on the job performance of information professionals (IPs) in any aspect. The purpose of this paper is to measure job performance of MPhil degree (18 years of education) holder IPs.

Design/methodology/approach
It is a quantitative study based on the theoretical framework of job performance comprised of its four constructs, i.e. task performance, contextual performance, counterproductive work behaviors (CWB) and adaptive performance. An adopted self-administered questionnaire was used to collect data from professionals who have graduated from any LIM schools of the Punjab province with at least one-year work experience after completion of MPhil degrees. For the purpose of the present study, demographic information like age, job experience and library context was also asked about to explore their impact on job performance.

Findings
Findings revealed that MPhil degree has a significant positive impact on the job performance of IPs. The professionals reported a significant positive change in their CWB regarding experience after getting a degree. Furthermore, results revealed that professionals were capable of technical skills but needed training regarding time management, teamwork and improving emotional intelligence.

Originality/value
This is the first study reported from Pakistan on the subject. The results of the study may help the LIM schools to review their MPhil programs for the desired results. It may also help organizations to encourage their personnel for higher education.
Effects of nature-based mindfulness training on resilience/symptom load in professionals with high work-related stress-levels: findings from the WIN-Study
Authors: Lücke Caroline , Braumandl Sylvia , Becker Bernhard , Moeller Sebastian , Custal Christina , Philipsen Alexandra , Müller Helge H.O. 
Published: November 2019

Purpose
The levels of work-related stress and the incidence rates of subsequent related illnesses are increasing in our society, leading to high individual and socioeconomic burdens. Mindfulness training has been shown to be an effective method of improving stress resilience. This paper aims to investigate the efficacy of nature-based mindfulness training in professionals with high levels of work-related stress.

Design/methodology/approach
In this controlled pilot study, a total of 56 volunteers completed a nature-based mindfulness training progam and were compared to 8 participants (waitlist controls). Psychometric assessments were performed at baseline and after two and four months of training.

Findings
After two months of training, the scores for self-efficacy, sense of coherence, level of mindfulness and overall psychiatric symptom load had significantly improved in the intervention group, while the control group did not show any significant improvements. A comparison between the intervention and control groups showed a significant difference regarding the sense of coherence only.

Research limitations/implications
Since this was an exploratory study with a small control group, further studies are needed to verify our findings.

Practical implications
In conclusion, nature-based mindfulness training seems to be a promising tool for the improvement of resilience and overall psychological health in professionals.

Originality/value
This was the first study to systematically investigate effects of nature-based mindfulness training in people with high work-related stress.
An applied model for predicting memory effects of flexible polyurethane foams
Authors: Elfarhani Makram , Mkaddem Ali , Alzahrani Ahmed A. , Bin Mahfouz Abdullah S. , Jarraya Abdessalem , Haddar Mohamed 
Published: November 2019

Purpose
The efficiency of fractional derivative and hereditary combined approach in modeling viscoelastic behavior of soft foams was successfully addressed in Elfarhani et al. (2016a). Since predictions obtained on flexible polyurethane foam (FPF) type A (density 28 kg m−3) were found very promoting, the purpose of this paper is to apply the approach basing on two other types of foams. Both soft polyurethane foams type B of density 42 kg m−3 and type C of density 50 kg m−3 were subjected to multi-cycles compressive tests.

Design/methodology/approach
The total foam response is assumed to be the sum of a non-linear elastic component and viscoelastic component. The elastic force is modeled by a seven-order polynomial function of displacement. The hereditary approach was applied during the loading half-cycles to simulate the short memory effects while the fractional derivative approach was applied during unloading cycles to simulate the long memory effects. An identification methodology based on the separation of the measurements of each component force was developed to avoid parameter admixture problems.

Findings
The proposed model reveals good reliability in predicting the responses of the two considered flexible foams. Predictions as measurements establish that residual responses were negligible compared to elastic and viscoelastic damping responses.

Originality/value
The development of a new combined model reveals good reliability in predicting the responses of the two polyurethane foams type A and B.
Supporting parents of children aged 2–13 with toileting difficulties: Group‐based workshops versus individual appointments
Authors: Collis Dianne , Kennedy‐Behr Ann , Kearney Lauren 
Published: December 2019

AbstractIntroductionToileting is a key activity of daily living and an important milestone in children’s development. Difficulties with this process can cause stress to both child and parents and negatively affect their wellbeing. This study compared the perceived parental competence and child wellbeing of families attending a group‐based workshop on toileting issues with families attending an individual appointment at a continence clinic.MethodsAll parents attending the workshops and attending the clinic between July 2016 and December 2017 were invited to participate in the study. The children were aged between 2 and 13 years. Three measures were used: 1) Parenting Sense of Competence Scale; (2) the Revised Quality of Life Questionnaire for Children (KINDLR) and (3) Parent self‐assessment of information and support needs. Participants completed all measures at three points: prior to intervention, 1 week and 1 month post‐intervention.ResultsData were collected from 89 parents attending the workshops and 46 parents attending the clinic. Children were not assessed. Non‐parametric tests were used to examine between group differences. Within group changes overtime were examined using Friedman’s two‐way analysis of variance. Parents who attended the workshop showed significant increases in parenting sense of competence and perceived child quality of life post‐intervention.Although there were significant differences between and pre‐ and post‐measures for workshop attendees, there were no significant differences found between the two groups indicating that both forms of intervention had beneficial results.ConclusionThese results suggest that group‐based workshops can positively impact parents’ perceived competence in managing their child’s toileting issues and wellbeing. Further research is recommended to explore the relationship between parenting competence and child wellbeing and to determine which aspects of the workshops were most beneficial.
Parents’ constructions of normality and pathology in child mental health assessments
Authors: O'Reilly Michelle , Muskett Tom , Karim Khalid , Lester Jessica N. 
Published: November 2019

AbstractCentral to a contemporary understanding of childhood is the developmental and clinical‐medical construct of the ‘normal’ child. When judged to fall outside of culturally, socially and historically situated parameters of ‘normality’, children become labelled as ‘deviant from the norm’; for instance, in mental health contexts where this may provide the basis for psychiatric diagnosis. However, judgements of a child's ‘normality’ are further complicated by the range of individuals who may have a stake in that construction, including parents/carers, professionals and the child themselves. Using discursive psychology, we analysed 28 video‐recorded UK child mental health assessments, to examine ways that parents presented concerns about their children's development. They did this by drawing on notions of ‘ab/normal’, in ways that functioned to legitimise their need for services and built a rhetorical case to demonstrate clinical need; often by contrasting the child with other ‘typical’ children and/or contrasting the same child's behaviour in different settings or contexts. We concluded that given the growing crisis in child mental health, initial assessments play a crucial clinical role in determining diagnosis and labelling, and therefore, a critical discussion of these concepts and processes is essential.
Maternal lipids are associated with newborn adiposity, independent of GDM status, obesity and insulin resistance: a prospective observational cohort study
Authors: Samsuddin S , Arumugam PA , Md. Amin Md.S , Yahya A , Musa N , Lim L‐L , Paramasivam SS , Ratnasingam J , Ibrahim L , Chooi KC , Tan ATB , Tan PC , Omar SZ , Samingan N , Ahmad Kamar A , Anuar Zaini A , Jalaluddin MY , Vethakkan SR 
Published: November 2019

ObjectiveTo determine the association between maternal lipaemia and neonatal anthropometrics in Malaysian mother–offspring pairs.DesignProspective observational cohort study.SettingSingle tertiary multidisciplinary antenatal clinic in Malaysia.PopulationA total of 507 mothers: 145 with gestational diabetes mellitus (GDM); 94 who were obese with normal glucose tolerance (NGT) (pre‐gravid body mass index, BMI ≥ 27.5 kg/m2), and 268 who were not obese with NGT.MethodsMaternal demographic, anthropometric, and clinical data were collected during an interview/examination using a structured questionnaire. Blood was drawn for insulin, C‐peptide, triglyceride (Tg), and non‐esterified fatty acid (NEFA) during the 75‐g 2‐hour oral glucose tolerance test (OGTT) screening, and again at 36 weeks of gestation. At birth, neonatal anthropometrics were assessed and data such as gestational weight gain (GWG) were extracted from the records.Main outcome measuresMacrosomia, large‐for‐gestational‐age (LGA) status, cohort‐specific birthweight (BW), neonatal fat mass (NFM), and sum of skinfold thickness (SSFT) > 90th centile.ResultsFasting Tg > 95th centile (3.6 mmol/L) at screening for OGTT was independently associated with LGA (adjusted odds ratio, aOR 10.82, 95% CI 1.26–93.37) after adjustment for maternal glucose, pre‐gravid BMI, and insulin sensitivity. Fasting glucose was independently associated with a birthweight ratio (BWR) of >90th centile (aOR 2.06, 95% CI 1.17–3.64), but not with LGA status, in this well‐treated GDM cohort with pre‐delivery HbA1c of 5.27%. In all, 45% of mothers had a pre‐gravid BMI of <23 kg/m2 and 61% had a pre‐gravid BMI of ≤ 25 kg/m2, yet a GWG of >10 kg was associated with a 4.25‐fold risk (95% CI 1.71–10.53) of BWR > 90th centile.ConclusionMaternal lipaemia and GWG at a low threshold (>10 kg) adversely impact neonatal adiposity in Asian offspring, independent of glucose, insulin resistance and pre‐gravid BMI. These may therefore be important modifiable metabolic targets in pregnancy.Tweetable abstractMaternal lipids are associated with adiposity in Asian babies independently of pre‐gravid BMI, GDM status, and insulin resistance.
Development and validation of a model to predict the need for emergency front‐of‐neck airway procedures in trauma patients
Authors: Okada Y. , Hashimoto K. , Ishii W. , Iiduka R. , Koike K. 
Published: December 2019

SummaryThe present study aimed to develop and validate a model for predicting the need for emergency front‐of neck airway (eFONA) procedures among trauma patients. This was a multicentre retrospective cohort study using data from the Japan Trauma Data Bank between January 2004 and December 2017. Only adult trauma patients were included. The cohort was divided into development and validation cohorts. A simple scoring system was developed to predict the necessity for emergency front‐of neck airway procedures in the development cohort using a logistic regression model. The external validity and diagnostic ability of the scoring system was assessed in the validation cohort. In total, 198,182 out of 294,274 patients were included; emergency front‐of‐neck airway occurred in 467 patients (0.24%) they were divided into development (n = 100,120 with 0.22% undergoing emergency front‐of neck airway) and validation (n = 98,062 with 0.25% undergoing emergency front‐of neck airway) cohorts. The ‘eFONA’ prediction scoring system was developed in the development cohort, with a score of +1 for each of the following: Eye opening (no eye opening in response to any stimuli); Fall from height or motor bike; Oral–maxillofacial injury; Neck tracheal injury; and Airway management by paramedics. In the validation cohort, the C‐statistic of the scoring system was 0.820. Setting the cut‐off value at one for rule‐out, the sensitivity and negative likelihood ratios were 0.86 and 0.22, respectively. Setting the cut‐off value at two for rule‐in, the specificity and positive likelihood ratios were 0.91 and 6.6, respectively. The present scoring system may assist in predicting the need for emergency front‐of neck airway procedures among the general trauma population.
Phase 1 study of capmatinib in MET‐positive solid tumor patients: Dose escalation and expansion of selected cohorts
Authors: Bang Yung‐Jue , Su Wu‐Chou , Schuler Martin , Nam Do‐Hyun , Lim Wan Teck , Bauer Todd M. , Azaro Analia , Poon Ronnie Tung Ping , Hong David , Lin Chia‐Chi , Akimov Mikhail , Ghebremariam Samson , Zhao Sylvia , Giovannini Monica , Ma Brigette 
Published: November 2019

AbstractCapmatinib is an oral, ATP‐competitive, and highly potent, type 1b MET inhibitor. Herein, we report phase 1 dose‐escalation results for capmatinib in advanced MET‐positive solid tumor patients and dose expansion in advanced non‐lung tumors. Capmatinib was well tolerated with a manageable safety profile across all explored doses. Dose‐limiting toxicities (DLT) occurred at 200 mg twice daily (bid), 250 mg bid, and 450 mg bid capsules; however, no DLT were reported at 600 mg bid (capsules). Capmatinib tablets at 400 mg bid had comparable tolerability and exposure to that of 600 mg bid capsules. Maximum tolerated dose was not reached; recommended phase 2 dose was 400 mg bid tablets/600 mg bid capsules; at this dose, Ctrough >EC90 (90% inhibition of c‐MET phosphorylation in animal models) is expected to be achieved and maintained. Among the dose‐expansion patients (N = 38), best overall response across all cohorts was stable disease (gastric cancer 22%, hepatocellular carcinoma 46%, other indications 28%); two other indication patients with gene copy number (GCN) ≥6 achieved substantial tumor reduction. Near‐complete immunohistochemically determined phospho‐MET inhibition (H‐score = 2) was shown following capmatinib 450 mg bid capsule in paired biopsies obtained from one advanced colorectal cancer patient. Incidence of high‐level MET GCN (GCN ≥6) and MET‐overexpressing (immunohistochemistry 3+) tumors in the expansion cohorts was 8% and 13%, respectively; no MET mutations were observed. Thus, the recommended phase 2 dose (RP2D) of capmatinib was 600 mg bid capsule/400 mg bid tablet. Capmatinib was well tolerated and showed antitumor activity and acceptable safety profile at the RP2D.(ClinicalTrials.gov Identifier: NCT01324479).
The expanding spectrum of movement disorders in genetic epilepsies
Authors: Papandreou Apostolos , Danti Federica Rachele , Spaull Robert , Leuzzi Vincenzo , Mctague Amy , Kurian Manju A 
Published: December 2019

An ever‐increasing number of neurogenetic conditions presenting with both epilepsy and atypical movements are now recognized. These disorders within the ‘genetic epilepsy‐dyskinesia’ spectrum are clinically and genetically heterogeneous. Increased clinical awareness is therefore necessary for a rational diagnostic approach. Furthermore, careful interpretation of genetic results is key to establishing the correct diagnosis and initiating disease‐specific management strategies in a timely fashion. In this review we describe the spectrum of movement disorders associated with genetically determined epilepsies. We also propose diagnostic strategies and putative pathogenic mechanisms causing these complex syndromes associated with both seizures and atypical motor control.What this paper adds

Implicated genes encode proteins with very diverse functions.

Pathophysiological mechanisms by which epilepsy and movement disorder phenotypes manifest are often not clear.

Early diagnosis of treatable disorders is essential and next generation sequencing may be required.
Persistent whole day meal effects of three dipeptidyl peptidase‐4 inhibitors on glycaemia and hormonal responses in metformin‐treated type 2 diabetes
Authors: Alsalim Wathik , Göransson Olga , Tura Andrea , Pacini Giovanni , Mari Andrea , Ahrén Bo 
Published: December 2019

AbstractAimDipeptidyl peptidase‐4 (DPP‐4) inhibition has effects on both fasting and postprandial glucose. However, the extent of this effect over the whole day and whether different DPP‐4 inhibitors have the same effects have not been established. We therefore explored the whole day effects of three different DPP‐4 inhibitors versus placebo on glucose, islet and incretin hormones after ingestion of breakfast, lunch and dinner in subjects with metformin‐treated and well‐controlled type 2 diabetes.MethodsThe study was single‐centre and crossover designed, involving 24 subjects [12 men, 12 women, mean age 63 years, body mass index 31.0 kg/m2, glycated haemoglobin 44.7 mmol/mol (6.2%)], who underwent four test days in random order. Each whole day test included ingestion of standardized breakfast (525 kcal), lunch (780 kcal) and dinner (560 kcal) after intake of sitagliptin (100 mg) or vildagliptin (50 mg twice), or saxagliptin (5 mg) or placebo.ResultsCompared with placebo, DPP‐4 inhibition reduced glucose levels, increased beta‐cell function (insulin secretory rate in relation to glucose), suppressed glucagon, increased intact glucagon‐like‐peptide‐1 (GLP‐1) and glucose‐dependent insulinotropic polypeptide (GIP) but suppressed total GLP‐1 and GIP after all three meals. The effects were sustained throughout the daytime period with similar changes after each meal and did not differ between the DPP‐4 inhibitors.ConclusionsDPP‐4 inhibition has persistent daytime effects on glucose, islet and incretin hormones with no difference between three different DPP‐4 inhibitors.
Clinical correlates of hand‐held ultrasound‐guided assessments of the inferior vena cava in patients with acute decompensated heart failure
Authors: Patnaik Soumya , Davila Carlos D. , Lu Marvin , Alhamshari Yaser , Shah Mahek , Jorde Ulrich P. , Pressman Gregg S. , Banerji Sourin 
Published: December 2019

AbstractBackgroundAccurately assessing volume status in acutely decompensated heart failure (ADHF) can be challenging. Inferior vena cava (IVC) dynamics by echocardiography allow indirect assessment of volume status in these patients. Recently introduced hand‐held ultrasound devices are promising. We aimed to describe the clinical correlates of volume status assessment using a hand‐held ultrasound device in ADHF.MethodsIn this prospective study, we evaluated 106 patients admitted with ADHF. First scan was performed within 24 hours of admission and timed in reference to first dose of intravenous diuretic. Daily resting and inspiratory (sniff) IVC diameters were measured according to standard echocardiography methods during hospitalization including the day of discharge. IVC collapsibility index (IVC‐CI = Maximum IVC diameter‐Inspiratory IVC diameter/maximum diameter; <0.5 representing hypervolemia) was calculated. Primary study endpoint was 30‐day readmission. Research activities were independent of clinical decision‐making.ResultsData for 106 patients was analyzed. Mean age was 66.7 ± 13.8 years, of which 53.8% were females, and a mean ejection fraction was 39 ± 18%. Initial scan of the IVC was obtained at an average time of 5.2 ± 8.04 hours from first diuretic dose. 81.2% of patients at admission had an IVC‐CI <0.5. 63.2% patients had an IVC‐CI <0.5 at discharge. There were no significant differences in age, length of stay, diuretic dose, or 30‐day readmissions between patients with a discharge IVC‐CI <0.5 vs ≥ 0.5.ConclusionHand‐held ultrasound assessment of IVC‐CI in ADHF patients, although a feasible concept, is unable to predict 30‐day readmissions in our study. Further prospective studies are necessary.