bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serial correlation structures in latent linear mixed models for analysis of multivariate longitudinal ordinal responses
Authors: Tran Trung Dung , Lesaffre Emmanuel , Verbeke Geert , Molenberghs Geert 
Published: October 2020

AbstractWe propose a latent linear mixed model to analyze multivariate longitudinal data of multiple ordinal variables, which are manifestations of fewer continuous latent variables. We focus on the latent level where the effects of observed covariates on the latent variables are of interest. We incorporate serial correlation into the variance component rather than assuming independent residuals. We show that misleading inference may be drawn when misspecifying the variance component. Furthermore, we provide a graphical tool depicting latent empirical semi‐variograms to detect serial correlation for latent stationary linear mixed models. We apply our proposed model to examine the treatment effect on patients having the amyotrophic lateral sclerosis disease. The result shows that the treatment can slow down progression of latent cervical and lumbar functions.
A two‐dimensional quantitative parametric investigation of simplified surface imperfections on the aerodynamic characteristics of a NACA 633‐418 airfoil
Authors: Krog Kruse Emil , Sørensen Niels N. , Bak Christian 
Published: October 2020

AbstractThe aerodynamic performance of a NACA 633‐418 airfoil has been analyzed with disturbances in approximately 1000 different configurations focused on the frontal 10% of the airfoil. The configuration parameters are based on field test samples and rain erosion test specimens. The most important trends are presented by 500 configurations each simulated for 6°, 8°, and 10° angle of attack. The simulations are performed with the DTU Wind Energy in‐house 2D CFD Reynolds‐averaged Navier–Stokes solver, EllipSys2D, combined with the eN transition model for the laminar‐turbulent boundary layer transition. The configurations are modeled by a direct geometrical modification of the airfoil shape. The results show that the most important parameters are the position and the depth/height of the disturbance, with up to 35% lift reduction and 90% lift/drag reduction within the specified angle of attacks and disturbance parameter ranges.
Introduction
Authors: Beck Hans Peter , Charitos Panagiotis 
Published: October 2020

Abstract
The present volume collects the proceedings of the workshop “The Economics of Science” that was held in June 2019 in Brussels in the framework of the FCC Week with the support of the H2020 EuroCirCol and EASITrain projects and the Belgium Charter of the LSE Alumni Association. The goal of the meeting was threefold: First to explore the role of public investments in research infrastructures and Big Science projects for economic development, review ways to access their financial impact beyond their core scientific mission and thirdly create a forum for exchanging best practices that can maximize the impact of such projects. The collected essays focus on Big Science Organizations that participated in the workshop while we should clarify to readers that by “Science” we mainly refer to curiosity-driven research. However, we hope that some of the ideas and tools discussed by the participants of the workshop can find applications in many ways.
Towards a Sustainable European Research Infrastructures Ecosystem
Authors: Ribeiro Margarida 
Published: October 2020

Abstract
Research Infrastructures (RIs) are of fundamental strategic importance for Europe’s global competitiveness and remain at the heart of the knowledge triangle of research, education and innovation. Of paramount importance is to coordinate the development and use of top infrastructures for data collection, management, processing and analysing while also ensuring the long-term sustainability of research infrastructures. The following essay touches on some of the key goals and available tools to develop world-class sustainable Research Infrastructures open and accessible to all researchers in Europe and beyond.
The European Spallation Source: Designing a Sustainable Research Infrastructure for Europe
Authors: Womersley John 
Published: October 2020

Abstract
The paper briefly outlines some of the key challenges in building sustainable support for any science megaproject, using the European Spallation Source (ESS) as an example. Beyond the project’s imminent socio-economic impact the essay also reflects on the broader question of how public investments in large-scale “Big Science” projects can tackle the present global inequalities by reshaping the current forces of globalization, offering more opportunities for participation and empowering marginalized groups that often feel excluded.
Socio-Economic Impact Assessments of ESA Programmes: A Brief Overview
Authors: Mathieu Charlotte 
Published: October 2020

Abstract
The European Space Agency (ESA) is an intergovernmental organisation established in the seventies with today 22 Member States. Its purpose is to promote cooperation between Member States, in space research and technology as well as in space applications. ESA’s Member States wish to ensure maximum benefits to the economy and society from their investments in space activities. The Agency, as any other modern public administration, has a responsibility to ensure the creation of value for society, in an end-to-end perspective (i.e. from technology research to service development). The paper briefly summarizes the outcome of ESA’s previous socio-economic impact assessment studies of its programmes and provides useful references.
Managing patient flows in radiation oncology during the COVID-19 pandemic
Authors: Akuamoa-Boateng Dennis , Wegen Simone , Ferdinandus Justin , Marksteder Regina , Baues Christian , Marnitz Simone 
Published: October 2020

AbstractPurposeThe described work aimed to avoid cancellations of indispensable treatments by implementing active patient flow management practices and optimizing infrastructure utilization in the radiation oncology department of a large university hospital and regional COVID-19 treatment center close to the first German SARS-CoV‑2 hotspot region Heinsberg in order to prevent nosocomial infections in patients and personnel during the pandemic.Patients and methodsThe study comprised year-to-date intervention analyses of in- and outpatient key procedures, machine occupancy, and no-show rates in calendar weeks 12 to 19 of 2019 and 2020 to evaluate effects of active patient flow management while monitoring nosocomial COVID-19 infections.ResultsActive patient flow management helped to maintain first-visit appointment compliance above 85.5%. A slight appointment reduction of 10.3% daily (p = 0.004) could still significantly increase downstream planning CT scheduling (p = 0.00001) and performance (p = 0.0001), resulting in an absolute 20.1% (p = 0.009) increment of CT performance while avoiding overbooking practices. Daily treatment start was significantly increased by an absolute value of 18.5% (p = 0.026). Hypofractionation and acceleration were significantly increased (p = 0.0043). Integrating strict testing guidelines, a distancing regimen for staff and patients, hygiene regulations, and precise appointment scheduling, no SARS-CoV‑2 infection in 164 tested radiation oncology service inpatients was observed.ConclusionIn times of reduced medical infrastructure capacities and resources, controlling infrastructural time per patient as well as optimizing facility utilization and personnel workload during treatment evaluation, planning, and irradiation can help to improve appointment compliance and quality management. Avoiding recurrent and preventable exposure to healthcare infrastructure has potential health benefits and might avert cross infections during the pandemic. Active patient flow management in high-risk COVID-19 regions can help Radiation Oncologists to continue and initiate treatments safely, instead of cancelling and deferring indicated therapies.
Complex patellofemoral reconstruction leads to improved physical and sexual activity in female patients suffering from chronic patellofemoral instability
Authors: Lutz Patricia M. , Winkler Philipp W. , Rupp Marco-Christopher , Geyer Stephanie , Imhoff Andreas B. , Feucht Matthias J. 
Published: October 2020

AbstractPurposeTo analyze postoperative physical and sexual activity as well as Quality of Life (QoL) after complex patellofemoral reconstructions in female patients suffering from chronic patellofemoral instability (PFI).MethodsFemale patients aged > 18 years undergoing complex patellofemoral reconstruction for chronic PFI were included. Complex patellofemoral reconstruction was defined as medial patellofemoral ligament reconstruction (MPFL-R) combined with at least one major bony procedure (distal femoral osteotomy, high tibial osteotomy, and trochleoplasty). Outcome was evaluated retrospectively after a minimum follow-up of 12 months using Tegner activity scale, Banff Patellofemoral Instability Instrument 2.0 (BPII 2.0), EuroQol-5D-3L (EQ-5D-3L), EuroQol Visual analog scale (EQ-VAS), and a questionnaire about sexual activity.ResultsA total of 34 females (mean age, 26 ± 5 years) with a mean follow-up of 45 ± 16 months were included. Seventy-seven percent had one major bony correction + MPFL-R and 24% had at least two major bony corrections + MPFL-R. The re-dislocation rate was 6%. Median Tegner activity scale improved from 3 (range 0–10) to 4 (range 2–6) (n.s.) and an improved activity level was observed in 49% of subjects. QoL scores showed an EQ-5D-3L Index Value of 0.89 ± 0.15, EQ-VAS of 80.3 ± 11.4, and BPII of 68.3 ± 19.1. Thirty-four percent of patients reported restrictions of sexual activities due to PFI preoperatively with an improved sexual function observed in 60% postoperatively due to less pain, improved mobility, and less apprehension. Postoperative return to sexual activity was 91%, whereof 19% reported current restrictions of sexual function because of pain and/or limited range of motion.ConclusionDespite the complexity and invasiveness of complex patellofemoral reconstruction, combined bony procedures and MPFL-R resulted in a low redislocation rate, improved physical activity and QoL comparable to values reported after isolated MPFL-R. Furthermore, sexual activity was improved in 60% of females with preoperative restrictions.Level of evidenceIV.
Incidence of concomitant chondral/osteochondral lesions in acute ankle fractures and their effect on clinical outcome: a systematic review and meta-analysis
Authors: Darwich Ali , Adam Julia , Dally Franz-Joseph , Hetjens Svetlana , Jawhar Ahmed 
Published: October 2020

Abstract
Introduction
Despite successful osteosynthesis, some patients report residual symptoms after ankle fractures. One of the reasons behind the postoperative complaints might be traumatic concomitant chondral lesions (CL) and/or osteochondral lesions (OCL) within the ankle joint. The study aims to systematically review the incidence of CL and/or OCL in ankle fractures and to assess their effect on the clinical outcome.

Materials and methods
This work was conducted according to PRISMA checklists. A systematic literature search was performed using following keywords: “Ankle Fractures” OR “Trimalleolar Fracture” OR “Bimalleolar Fracture” OR “Maisonneuve fracture” OR “Malleolus Fracture” AND “Cartilage” OR “Cartilage Diseases” OR “Cartilage, Articular” OR “chondral” up to March 2020. The identified articles were analysed to determine the incidence of CL and/or OCL. Included studies in the meta-analysis assessed possible cartilage damage through arthroscopy or MRI immediately after traumatic ankle fractures and described the postoperative clinical outcome.

Results
The search identified a total of 111 publications; 19 described the incidence of CL and/or OCL after ankle fractures; six met the criteria to be included in the meta-analysis: five (n = 293) diagnosed CL and/or OCL through arthroscopy during ORIF and one study (n = 153) used preoperative MRI. The clinical outcome was evaluated in four studies (n = 177) using AOFAS score and in two (n = 269) using FAOS score. The mean incidence of arthroscopically detected CL and/or OCL was 65 ± 21% [95% CI 53.9 to 76.72]. The cumulative meta-analysis sample size comprised a total of 400 Patients (170 with and 230 without CL and/or OCL) available for a mean follow-up of 23.9 ± 11.5 months [95% CI 11.79 to 36.07]. The average age was 44.3 ± 5.5 years [95% CI 38.57 to 50.13]. The meta-analysis revealed a mean AOFAS score of 91.2 ± 4.8 [95% CI 83.53 to 98.93] with versus 94.4 ± 4.7 [95% CI 86.81 to 102.07] without CL and/or OCL (p = 0.15) and a mean FAOS score of 73.2 ± 11.31 [95% CI − 28.44 to 174.85] with versus 79.0 ± 18.4 [95% CI − 86.77 to 244.87] without CL and/or OCL (p = 0.18).

Conclusions
CL and/or OCL appear very frequently after ankle fractures. A tendency towards a favourable short- to mid-term clinical outcome was noticed in ankle fractures without CL and/or OCL, however without reaching statistical significance.

Level of evidence
Level I.
Cucullanus carettae Baylis, 1923, in a loggerhead sea turtle (Caretta caretta) from the Adriatic sea: first detection and molecular characterization
Authors: Di Renzo L. , Di Gialleonardo L. , Marchiori E. , Di Francesco G. , Curini V. , Cocco A. , Guccione S. , Ferri N. , Marcer F. , Cammà C. , Pascucci I. 
Published: October 2020

AbstractCucullanus carettae Baylis, 1923 (Nematoda: Cucullanidae) is found worldwide in loggerhead turtles (Caretta caretta). Regarding the Mediterranean, C. carettae has been identified in the Tyrrhenian and the Ionian Sea and a unique description of a Cucullanus sp. specimen in loggerheads from the Adriatic Sea has been reported in the literature so far. In the framework of a bio-monitoring project of the Abruzzo and Molise coasts, a parasitological survey was performed on stranded and by-caught sea turtles, at the Istituto Zooprofilattico of Abruzzo and Molise “G. Caporale.” During necropsy, the gastrointestinal system of 72 stranded loggerhead turtles was analyzed for the presence of endoparasites and fecal samples were collected for coprological examination. Adult C. carettae (n = 123) was found in the upper intestine of one loggerhead turtle, associated with chronic lymphoplasmocytic enteritis. Additionally, five stool samples (6.9%) were positive for Cucullanus sp. eggs. Molecular characterization of adult nematodes was carried out to study phylogenetic relationships among the Cucullanus species. To our knowledge, this is the first morphological and molecular identification of C. carettae in loggerhead turtles from the Adriatic Sea. Additional studies on the distribution of this parasite in the Mediterranean are encouraged.
On the topological convergence of multi-rule sequences of sets and fractal patterns
Authors: Caldarola Fabio , Maiolo Mario 
Published: October 2020

AbstractIn many cases occurring in the real world and studied in science and engineering, non-homogeneous fractal forms often emerge with striking characteristics of cyclicity or periodicity. The authors, for example, have repeatedly traced these characteristics in hydrological basins, hydraulic networks, water demand, and various datasets. But, unfortunately, today we do not yet have well-developed and at the same time simple-to-use mathematical models that allow, above all scientists and engineers, to interpret these phenomena. An interesting idea was firstly proposed by Sergeyev in 2007 under the name of “blinking fractals.” In this paper we investigate from a pure geometric point of view the fractal properties, with their computational aspects, of two main examples generated by a system of multiple rules and which are enlightening for the theme. Strengthened by them, we then propose an address for an easy formalization of the concept of blinking fractal and we discuss some possible applications and future work.
Developing Personalized Education: A Dynamic Framework
Authors: Tetzlaff Leonard , Schmiedek Florian , Brod Garvin 
Published: October 2020

AbstractPersonalized education—the systematic adaptation of instruction to individual learners—has been a long-striven goal. We review research on personalized education that has been conducted in the laboratory, in the classroom, and in digital learning environments. Across all learning environments, we find that personalization is most successful when relevant learner characteristics are measured repeatedly during the learning process and when these data are used to adapt instruction in a systematic way. Building on these observations, we propose a novel, dynamic framework of personalization that conceptualizes learners as dynamic entities that change during and in interaction with the instructional process. As these dynamics manifest on different timescales, so do the opportunities for instructional adaptations—ranging from setting appropriate learning goals at the macroscale to reacting to affective-motivational fluctuations at the microscale. We argue that instructional design needs to take these dynamics into account in order to adapt to a specific learner at a specific point in time. Finally, we provide some examples of successful, dynamic adaptations and discuss future directions that arise from a dynamic conceptualization of personalization.
The quantity-quality tradeoff: a cross-national, longitudinal analysis of national student-faculty ratios in higher education
Authors: Buckner Elizabeth , Zhang You 
Published: October 2020

AbstractThis article analyzes cross-national trends in national student-faculty ratios (SFRs) over the past five decades. In descriptive analyses, we find that SFRs have increased globally, driven by particularly large increases in low-income countries. We analyze two cross-national datasets to examine factors associated with national SFRs. We find that national SFRs are positively associated with gross tertiary enrollment rates and particularly so in low-income countries. In contrast, both the female share of faculty and research spending are associated with having lower national SFRs. The findings shed light on how national higher education systems are responding to massification pressures and suggest that differentiating faculty roles is one way that countries curb their rising SFRs as enrollments grow.
I Would like to, but I can’t. An Online Survey on the Moral Challenges of German Farm Veterinarians
Authors: Dürnberger Christian 
Published: October 2020

AbstractThe job of veterinarians is often described as morally challenging. This online survey (n = 123) investigated how farm veterinarians in Germany perceive these challenges. Most participants described their job in accordance with the literature: as a profession that regularly has to deal with morally difficult decisions. The majority assumed that their moral challenges were greater than the ones of small animal practitioners. The results indicate that the typical moral challenges are (a) situations in which the farm veterinarians are convinced to know what is morally right, however, specific external obstacles prevent them from implementing their convictions. Therefore, the central moral problem from the veterinarians’ point of view can be described with the following words: “I would like to, but I can’t.” Other ideal types of moral challenges like (b) open ethical questions, (c) ethical dilemmas or (d) “duty vs. inclination” conflicts play a less prominent role. With regard to dealing with these challenges, the study shows that farm veterinarians are looking for exchange, for example with colleagues. Most participants see the current social debate about livestock farming as something that stresses them, arguing that their university’s curriculum did not adequately prepare them to participate in these controversies.
Photo-Seebeck study of amorphous germanium–tellurium-oxide films
Authors: Gholizadeh A. Baset , Walton Alex S. , Smith Richard , England Jonathan , Craig Christopher , Hewak Dan , Curry Richard J. 
Published: October 2020

AbstractThe measurement of the Seebeck coefficient of thin film (100 nm) amorphous germanium telluride containing ~ 31% oxygen under dark conditions and when exposed to monochromatic light in the 400 nm to 1800 nm wavelength region is reported. Exposure of the films to light is found to reduce the absolute value of the Seebeck coefficient compared to that measured in the dark. Furthermore, the magnitude of this reduction displays a distinctive spectral dependence over the wavelength range covered. The observed behaviour suggests that these measurements provide a method determining the optical bandgap of thin amorphous chalcogenide films. Further analysis of the data, along with that of X-ray photoelectron spectroscopy and photoconductivity studies, is used to determine the presence of sub-bandgap defect states and their role in determining the optical response of the Seebeck coefficient.
Awakening Compassion in Managers—a New Emotional Skills Intervention to Improve Managerial Compassion
Authors: Paakkanen Miia , Martela Frank , Hakanen Jari , Uusitalo Lotta , Pessi Anne 
Published: October 2020

AbstractCompassion is in high demand within organizational research, with important implications for leadership, well-being, and productivity. However, thus far only meditation-based interventions have been implemented to increase compassion in organizations. Our aim was to explore whether compassion could be increased among managers through improving their emotional skills. We implemented a quasi-randomized controlled trial with pre-test and post-test design of a new emotional skills cultivation training among managers, measuring the treatment group (N = 68), the control group (N = 90), and their followers (N = 85 and N = 72). Compared to the control group, the managers exhibited significantly increased sense of emotional skills, with some evidence for an improved sense of compassion. We also found that emotional skills mediated the impact of participating in the intervention group and compassion. Additionally, servant leadership behaviors in the intervention group improved following the intervention. These results demonstrate that instead of being something innate, compassion is a skill that can be increased through training emotional skills, with observable benefits for the organization.