bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced Recovery after Surgery for Cesarean Delivery Decreases Length of Hospital Stay and Opioid Consumption: A Quality Improvement Initiative
Authors: Shinnick Julia K. , Ruhotina Merima , Has Phinnara , Kelly Bridget J. , Brousseau E. Christine , O'Brien James , Peahl Alex Friedman 
Published: June 2020

Objective The aim of this study is to assess the effect of a resident-led enhanced recovery after surgery (ERAS) protocol for scheduled prelabor cesarean deliveries on hospital length of stay and postpartum opioid consumption.
Study Design This retrospective cohort study included patients who underwent scheduled prelabor cesarean deliveries before and after implementation of an ERAS protocol at a single academic tertiary care institution. The primary outcome was length of stay following cesarean delivery. Secondary outcomes included protocol adherence, inpatient opioid consumption, and patient-centered outcomes. The protocol included multimodal analgesia and antiemetic medications, expedited urinary catheter removal, early discontinuation of maintenance intravenous fluids, and early ambulation.
Results A total of 250 patients were included in the study: 122 in the pre-ERAS cohort and 128 in the post-ERAS cohort. There were no differences in baseline demographics, medical comorbidities, or cesarean delivery characteristics between the two groups. Following protocol implementation, hospital length of stay decreased by an average of 7.9 hours (pre-ERAS 82.1 vs. post-ERAS 74.2, p < 0.001). There was 89.8% adherence to the entire protocol as written. Opioid consumption decreased by an average of 36.5 mg of oxycodone per patient, with no significant differences in pain scores from postoperative day 1 to postoperative day 4 (all p > 0.05).
Conclusion A resident-driven quality improvement project was associated with decreased length of hospital stay, decreased opioid consumption, and unchanged visual analog pain scores at the time of hospital discharge. Implementation of this ERAS protocol is feasible and effective.
Key Points
Opções atuais de transferências tendíneas para lesões posterossuperiores irreparáveis do manguito rotador
Authors: Checchia Caio Santos , Silva Luciana Andrade da , Sella Guilherme do Val , Fregoneze Marcelo , Miyazaki Alberto Naoki 
Published: June 2020

ResumoAs grandes lesões posterossuperiores irreparáveis do manguito rotador são debilitantes e, de modo geral, requerem tratamento cirúrgico. Embora não haja consenso sobre a melhor técnica cirúrgica, as transferências tendíneas no ombro são os procedimentos mais realizados. O tendão do grande dorsal continua a ser o mais utilizado, mas diferentes modificações na técnica original têm minimizado as complicações e melhorado os resultados funcionais e a satisfação com o procedimento. Outras técnicas, como a transferência do tendão do trapézio inferior, são promissoras e devem ser consideradas, principalmente em pacientes com perda isolada da rotação externa. Este artigo é uma revisão da literatura a respeito da transferência de tendões para tratamento das lesões posterossuperiores irreparáveis do manguito rotador.
Evaluation of High-Dose Vitamin A Treatment in Postmolar Patients with Low and Plateauing Serum Human Chorionic Gonadotropin Levels
Authors: Uberti Elza Maria Hartmann , Diaz Ruth Karina Escobar , Cardoso Rodrigo Bernardes , Braga Antonio 
Published: June 2020

Abstract
Objective To compare the effect of high-dose vitamin A (HD Vit-A) use during postmolar follow-up of patients with low and plateauing (L&P) serum human chorionic gonadotropin (hCG) levels, from the moment serum hCG plateaued (P-hCG) to the first normal serum hCG value (< 5 IU/L).
Methods The present retrospective series case study compared two nonconcurrent cohorts of patients. Control group (CG): 34 patients with L&P serum hCG levels who underwent expectant management for 6 months after uterine evacuation, from 1992 to 2010; study group (SG): 32 patients in similar conditions who received 200,000 IU of Vit-A daily, from the identification of a P-hCG level to the first normal hCG value or the diagnosis of progression to gestational trophoblastic neoplasia (GTN), from 2011 to 2017. The present study was approved by the Ethics Committee of the institution where it was conducted.
Results In both groups, the prevalence of persistent L&P serum hCG levels was < 5%. In the SG, hCG levels at plateau were higher (CG = 85.5 versus SG = 195 IU/L; p = 0.028), the rate of postmolar GTN was lower (CG = 29.4% versus SG = 6.3%, p = 0.034) and follow-up was shorter (CG = 14 versus SG = 10 months, p < 0.001). During GTN follow-up, there were no differences in GTN staging or treatment aggressiveness in both groups. High-dose Vit-A use did not have any relevant toxic effect. There were no GTN relapses or deaths.
Conclusion The limited use of HD Vit-A seems to have a safe and significant effect on the treatment of postmolar patients with L&P serum hCG levels and may decrease the development of postmolar GTN in this population.
Análise da qualidade metodológica de revisões sistemáticas para tratamento de disfunções do manguito rotador
Authors: Estevam Jhony de Almeida , Franco Eduardo Signorini Bicas , Kriebel Carolina Falconi , Peccin Maria Stella 
Published: June 2020

Resumo
Objetivo Avaliar a qualidade metodológica das revisões sistemáticas para tratamento cirúrgico e não cirúrgico de indivíduos com síndrome do manguito rotador; comparar, através do instrumento Assessingthemethodologicalqualityofsystematic reviews(AMSTAR, na sigla em inglês), a qualidade dos estudos encontrados nas bases de dados Cochrane Library, PubMed (Publisher Medline), EMBASE e Qinsight.
Métodos Trata-se de um estudo transversal descritivo e comparativo, em que dois autores independentes analisaram, por meio do instrumento AMSTAR, a qualidade metodológica das revisões sistemáticas Cochrane e nãoCochrane sobre tratamento de indivíduos com diagnóstico de síndrome do manguito rotador.
Resultados 76 revisões sistemáticas foram avaliadas pelo instrumento AMSTAR. O escore médio geral foi de 6,1(±2,1) e a média por base de dados foi 9,1(±0,9) para as revisões Cochrane e 5,7(±1,8) para as não Cochrane. O item de menor pontuação do AMSTAR foi 11, relacionada à exibição dos conflitos de interesse da publicação. Em uma análise comparativa do escore da variável final, houve uma diferença estatística entre os estudos Cochrane e nãoCochrane.
Conclusão De acordo com o presenteestudo, revisões sistemáticas utilizando a metodologia Cochrane têm uma melhor qualidade metodológica em comparação com estudos nãoCochrane sobre o tratamento de disfunções do manguito rotador.
The Real Impact of the Coronavirus Disease 2019 (covid-19) on the Pregnancy Outcome
Authors: Gonçalves Ana Katherine 
Published: June 2020

AbstractThe COVID-19 outbreak is increasing around the world in the number of cases, deaths, and affected countries. Currently, the knowledge regarding the clinical impact of COVID-19 on maternal, fetal, and placental aspects of pregnancy is minimal. Although the elderly and men were the most affected population, in previous situations, such as the 2009 H1N1 influenza pandemic and the Ebola epidemic, pregnant women were more likely to develop complications than nonpregnant women. There are unanswered questions specific to pregnant women, such as whether pregnant women are more severely affected and whether intrauterine transmission occurs. Additional information is needed to inform key decisions, such as whether pregnant health care workers should receive special consideration, whether to separate infected mothers and their newborns, and whether it is safe for infected women to breastfeed.
Interference in between the acts of pre- and postselection
Authors: Rostom A. 
Published: June 2020

Abstract
As an alternative approach for measuring the weak effects associated with the artificial preparation of rare events in quantum metrology, we propose the study of the interference pattern generated by acts of pre- and postselection of a quantum system. An example of two Mach – Zehnder interferometers connected by a cross-Kerr nonlinearity is considered. Postselection of photon states at the output of one of the interferometers and the application of a controlled phase shift in one of its arms induces interference phenomena in the photodetection statistics at the output of the second interferometer. The nonlinearity parameter determines the shift and width of the structures in the interference pattern. The main features of this pattern are studied depending on the magnitude of the Kerr nonlinearity and the number of photons at the input of the interferometers.
Detection of the clock transition in thulium atoms by using repump laser radiation
Authors: Tregubov D.O. , Golovizin A.A. , Fedorova E.S. , Mishin D.A. , Provorchenko D.I. , Khabarova K.Yu. , Sorokin V.N. , Kolachevsky N.N. 
Published: June 2020

Abstract
A population transfer from the upper level of the clock transition in thulium atoms to the ground level is demonstrated by using radiation with a wavelength of 402 nm. The method for detecting the clock transition excitation that is not affected by technical fluctuations of the number of atoms in an optical lattice is investigated. The hyperfine splitting of the |4f12(3F2)5d5/2 6s2; J = 7/2〉 level in the thulium atom is measured to be 1480(9) MHz. The suggested method for population transfer can be applied to both the hyperfine components of the clock transition intended for compensating Zeeman effect in a thulium optical clock.
Liquid network connectivity regulates the stability and composition of biomolecular condensates with many components
Authors: Espinosa Jorge R. , Joseph Jerelle A. , Sanchez-Burgos Ignacio , Garaizar Adiran , Frenkel Daan , Collepardo-Guevara Rosana 
Published: June 2020

Significance
LLPS plays an important role in the spatiotemporal organization of the numerous molecular constituents of living cells, via formation of biomolecular condensates. Our simulations provide predictive rules governing the stability and composition of multicomponent biomolecular condensates. Biomolecules that increase the molecular connectivity of condensates are present in higher concentrations because connectivity is positively correlated with stability. Greater connectivity within highly multicomponent condensates manifests in higher critical temperatures in the phase diagrams of accessible systems involving just a few components. Hence, composition of highly multicomponent condensates can be predicted from the critical points of reduced-component mixtures. Our findings expand the mechanisms relating phase behavior of multicomponent intracellular mixtures to critical parameters (temperature, pH, salt concentration, etc.) of the constituent biomolecules.
MAML1/2 promote YAP/TAZ nuclear localization and tumorigenesis
Authors: Kim Jiyoung , Kwon Hyeryun , Shin You Keun , Song Gahyeon , Lee Taebok , Kim Youngeun , Jeong Wonyoung , Lee Ukjin , Zhang Xianglan , Nam Gilyeong , Jeung Hei-Cheul , Kim Wantae , Jho Eek-hoon 
Published: June 2020

Significance
The Hippo-YAP/TAZ pathway plays pivotal roles in controlling tissue growth, and its abnormal regulation is frequently implicated in a variety of cancers. We have identified MAML1/2 as critical regulators for YAP/TAZ nuclear retention and transcription activities. Clinical analysis with specimens of a human cancer patient and a public cancer database reveals pathological association between MAML expression and YAP signature. Furthermore, our results suggest that the cell density governing YAP/TAZ subcellular localization can also function as an important intrinsic mechanism for miR30c-dependent regulation of MAML1 level. Our findings provide mechanistic insights of YAP/TAZ-dependent growth control pathway and tumorigenesis.
A Spatiotemporal Trajectory Data Index Based on the Hilbert Curve Code
Authors: Wu YuHao , Cao Xuefeng , An Zipeng 
Published: June 2020

Abstract
Massive trajectory data have been accumulated with the rapid development of global positioning technology and the popularisation of intelligent mobile terminal. However, the generation of massive data does not necessarily lead to the increase in effective data. An index method meeting the efficient management requirements of spatiotemporal trajectory data needs to be designed for the efficient spatiotemporal analysis and calculation of data. This paper proposes a spatiotemporal index method based on the Hilbert curve code to solve this problem. Firstly, the method constructs a multi-scale spatiotemporal grid model covering the whole world by dividing the three-dimensional space composed of time, latitude and longitude. Secondly, the grid cell codes are designed based on the Hilbert curve for hierarchical organisation of the trajectory data. Finally, the corresponding query process based on the code index is proposed in accordance with the different spatiotemporal query requirements of trajectory data. The comparison experiments show that the proposed method is more efficient than the existing spatiotemporal index method and can effectively support the management of massive multi-scale trajectory data.
Research on Urban Building Extraction Method Based on Deep Learning Convolutional Neural Network
Authors: Lv Beiru , Peng Ling , Wu Tong , Chen Ruonan 
Published: June 2020

Abstract
Buildings’ location information is an important basic data for the construction of refined smart city. Using remote sensing images to obtain building information is both high-quality and efficiency. However, urban village building is a very special category in remote sensing image of urban area. The distribution patterns of buildings inside the urban village is quite unique, such as high building density, narrow streets and lanes, concentrated illegal buildings, which brings various high-risk security risks. Therefore, how to use remote sensing technique to detect the structural characteristics and explore the spatial distribution patterns of urban village buildings through massive urban image data is of great significance to both planning and governing urban villages. Traditional remote sensing image building extraction methods have the problems of large workload, low efficiency and slow update, and the buildings in the urban village has complex building types and serious interference of deposits. To tackle the above issues, this paper adopts the deep learning convolutional neural network algorithm which is the advanced method in the field of computer vision, and proposes a building extraction method based on high-resolution remote sensing images. In this paper, Mask R-CNN, an instance segmentation method, is used to extract urban village buildings. After trained on 678 samples, this method reached 66% mAP on test dataset. In addition, spatial distribution patterns of the research area are analysed based on the detection result. The spatial analyzation results show that buildings in the research area are with small average building area and large building density and do not compliance with regulations of People’s Republic of China on the Planning and Design Standards for Urban Residential Areas.
Sensitivity Analysis of Vegetation Coverage to Soil Loss Rate in Red Soil Region of South China
Authors: Yifeng Liu , Xiaoqin Wang , Miaojin Chen 
Published: June 2020

Abstract
Vegetation is an important basic component of terrestrial ecosystem and one of the most sensitive factors affecting soil erosion. How to analyse the quantitative relationship between fractional vegetation cover (FVC) and soil erosion and determine the sensitive coverage of erosion is of great significance for guiding government departments to implement soil and water conservation policies. In this paper, through the variable-controlling mothed, the forest land, grassland and bare land in Changting County, a typical red soil region in southern China, were used as experimental areas to study the sensitivity of FVC change to soil erosion. The soil erosion amount was calculated by RUSLE model, and soil loss rate (rsl) were used to characterize soil erosion. The results show that when FVC changes from 0 to 0.8, the fitting curves rsl are in accordance with the logistic model distributions, with a high coefficient of determination R2, and the sensitivity of rsl is less sensitive in the range of 0∼0.05, it is most sensitive when FVC reaches a certain level, and there is basically no sensitivity when it reaches 0.7 or above; the fitting curves of rsl at different slope levels are similar to their overall distribution, which are consistent with the logistic models, and R2 is above 0.99, the curves of rsl at each slope level are different in the same FVC interval, for areas with poor vegetation coverage (0∼0.2) and high slope (>25°), the curve is less sensitive to terrain; rsl generally has higher sensitivity in the range of 0.2∼0.6 coverage; in areas above 0.6, the sensitivity decreases to zero.
3D printed oxidized alginate-gelatin bioink provides guidance for C2C12 muscle precursor cell orientation and differentiation via shear stress during bioprinting
Authors: Distler Thomas , Solisito Aditya A , Schneidereit Dominik , Friedrich Oliver , Detsch Rainer , Boccaccini Aldo R 
Published: June 2020

Abstract
Biofabrication can be a tool to three-dimensionally (3D) print muscle cells embedded inside hydrogel biomaterials, ultimately aiming to mimic the complexity of the native muscle tissue and to create in-vitro muscle analogues for advanced repair therapies and drug testing. However, to 3D print muscle analogues of high cell alignment and synchronous contraction, the effect of biofabrication process parameters on myoblast growth has to be understood. A suitable biomaterial matrix is required to provide 3D printability as well as matrix degradation to create space for cell proliferation, matrix remodelling capacity, and cell differentiation. We demonstrate that by the proper selection of nozzle size and extrusion pressure, the shear stress during extrusion-bioprinting of mouse myoblast cells (C2C12) can achieve cell orientation when using oxidized alginate-gelatin (ADA-GEL) hydrogel bionk. The cells grow in the direction of printing, migrate to the hydrogel surface over time, and differentiate into ordered myotube segments in areas of high cell density. Together, our results show that ADA-GEL hydrogel can be a simple and cost-efficient biodegradable bioink that allows the successful 3D bioprinting and cultivation of C2C12 cells in-vitro to study muscle engineering.
Improving alginate printability for biofabrication: establishment of a universal and homogeneous pre-crosslinking technique
Authors: Hazur Jonas , Detsch Rainer , Karakaya Emine , Kaschta Joachim , Teßmar Jörg , Schneidereit Dominik , Friedrich Oliver , Schubert Dirk W , Boccaccini Aldo R 
Published: June 2020

Abstract
Many different biofabrication approaches as well as a variety of bioinks have been developed by researchers working in the field of tissue engineering. A main challenge for bioinks often remains the difficulty to achieve shape fidelity after printing. In order to overcome this issue, a homogeneous pre-crosslinking technique, which is universally applicable to all alginate-based materials, was developed. In this study, the Young’s Modulus after post-crosslinking of selected hydrogels, as well as the chemical characterization of alginate in terms of M/G ratio and molecular weight, were determined. With our technique it was possible to markedly enhance the printability of a 2% (w/v) alginate solution, without using a higher polymer content, fillers or support structures. 3D porous scaffolds with a height of around 5 mm were printed. Furthermore, the rheological behavior of different pre-crosslinking degrees was studied. Shear forces on cells as well as the flow profile of the bioink inside the printing nozzle during the process were estimated. A high cell viability of printed NIH/3T3 cells embedded in the novel bioink of more than 85% over a time period of two weeks could be observed.
Multi-layer lithography using focal plane changing for SU-8 microstructures
Authors: Chen Qiming , Zhou Jinyun , Zheng Qi , Hu Yiming 
Published: June 2020

Abstract
In this paper, we report on a type of SU-8 microstructure with vertical sidewalls used for polydimethydiloxane (PDMS) microchannels. Multi-layer lithography using focal plane changing approach is proposed to expose the SU-8 photoresist based on a digital micromirror device (DMD) maskless lithography system. We used a light-emitting diode source with a wavelength of 405 nm. The thickness of the SU-8 is divided into multi-layers according to the depth of focus. Each layer corresponds to a depth of focus, and then, a virtual mask is designed for the layer. Finally, each layer is exposed to changes in the focal plane. The results indicate that the actual profile of the SU-8 mold shows good agreement with the design profile without any T-profiles. Additionally, there is better linewidth in the proposed method compared with multi-exposure by a single fixed focal plane. The PDMS microchannels result also demonstrate the stability of the SU-8 mold.
Investigating the mechanical behavior of hydroxyapatite-reduced graphene oxide nanocomposite under different loading rates
Authors: Nosrati Hassan , Sarraf-Mamoory Rasoul , Le Dang Quang Svend , Ahmadi Amir Hossein , Canillas Perez Maria , Bünger Cody Eric 
Published: June 2020

Abstract
In this study, the hydroxyapatite (HA)-reduced graphene oxide (rGO) nanocomposite was investigated for its mechanical properties. The nanocomposite used in this study was made in two stages. The HA-rGO powders were first synthesized by hydrogen gas injected hydrothermal method, and then consolidated by spark plasma sintering. HA-rGO nanocomposite was subjected to Vickers indentation experiments with different loading rates. Various analyzes have been used in this study, including x-rays diffraction, field emission scanning electron microscopy, high-resolution transmission electron microscopy, fast fourier transform, and inverse fast fourier transform. The findings of this study showed that the HA in this nanocomposite was reinforced with rGO sheets coated with HA. As the loading rate increased, the slope of the curves in the elastic region was increased, indicating that the elastic modulus was increased. Also, the contact depth at higher loading rates was increased. Plastic deformation was higher at higher loading rates and the hardness had increased. As the loading rate increased from 300 mN to 1 N, the hardness and elastic modulus increased with more slope than when the loading rate changed from 1 N to 2 N. The presence of rGO sheets had partially controlled the HA brittleness.
A dilemma for permissibility-based solutions to the paradox of supererogation
Authors: Uzunova Marina , Ferguson Benjamin 
Published: June 2020

Abstract
We argue that permissibility-based solutions to the paradox of supererogation encounter a nested dilemma. Such approaches solve the paradox by distinguishing moral and rational permissions. If they do not also include a bridge condition that relates these two permissions, then they violate a very plausible monotonicity condition. If they do include a bridge condition, then permissibility-based solutions either amount to rational satisficing or they collapse back into the classical account of supererogation and fail to resolve the paradox.