bluuebunny/crossref_metadata_2025_split huggingface dataset:
Model-based vibration control for optical lenses
Authors: Störkle Johannes , Eberhard Peter 
Published: January 2020

AbstractThis work presents a contribution to the active image stabilization of optical systems, involving model development, control design, and the hardware setup. A laboratory experiment is built, which demonstrates the vibration sensitivity of a mechanical-optical system. In order to stabilize the undesired image motion actively, a model-based compensation of the image vibration is developed, realized and tested. Beside a linear actuator motion system, a force sensor system and a position sensor system are introduced and analyzed. In particular, various low-cost hardware components of the Arduino platform are used, which support the deployment of the controller software based on Matlab-Simulink. The remaining image motion is measured with a high-speed vision sensor system and the performance of the overall system is assessed.
The effects of traffic noise on tadpole behavior and development
Authors: Castaneda Erica , Leavings Vernell R. , Noss Reed F. , Grace Molly K. 
Published: January 2020

AbstractTraffic noise is known to negatively affect many wildlife species by interfering with foraging behavior. Frogs often lay their eggs in roadside ditches because they are predator-free, but it is possible that traffic noise could reduce the survival and fitness of tadpoles, creating an ecological trap. In a series of lab experiments, we tested whether traffic noise has a negative impact on tadpole feeding behavior, whether this is mediated by changes in tadpole activity, and whether there is any impact on tadpole growth rate or metamorphosis. Traffic noise exposure significantly reduced the amount of food consumed by Cuban Treefrog (Osteopilus septentrionalis) tadpoles. Traffic noise exposure also increased the activity level of both Southern Toad (Anaxyrus terrestris) and Cuban Treefrog tadpoles, which could possibly make them more noticeable to predators in the wild. However, these behavioral changes were not associated with changes in growth rate or timing of metamorphosis. We caution, however, that this study aimed to isolate the specific impact of traffic noise, and did not investigate other road effects that may be damaging to tadpoles.
Preclinical Evaluation and Dosimetry of [111In]CHX-DTPA-scFv78-Fc Targeting Endosialin/Tumor Endothelial Marker 1 (TEM1)
Authors: Cicone Francesco , Denoël Thibaut , Gnesin Silvano , Riggi Nicolo , Irving Melita , Jakka Gopinadh , Schaefer Niklaus , Viertl David , Coukos George , Prior John O. 
Published: January 2020

AbstractPurposeEndosialin/tumor endothelial marker-1 (TEM1) is an attractive theranostic target expressed by the microenvironment of a wide range of tumors, as well as by sarcoma and neuroblastoma cells. We report on the radiolabeling and preclinical evaluation of the scFv78-Fc, a fully human TEM1-targeting antibody fragment cross-reactive with mouse TEM1.ProceduresThe scFv78-Fc was conjugated with the chelatorp-SCN-Bn-CHX-A”-DTPA, followed by labeling with indium-111. The number of chelators per molecule was estimated by mass spectrometry. A conventional saturation assay, extrapolated to infinite antigen concentration, was used to determine the immunoreactive fraction of the radioimmunoconjugate. The radiopharmaceutical biodistribution was assessed in immunodeficient mice grafted with Ewing’s sarcoma RD-ES and neuroblastoma SK-N-AS human TEM1-positive tumors. The full biodistribution studies were preceded by a dose-escalation experiment based on the simultaneous administration of the radiopharmaceutical with increasing amounts of unlabeled scFv78-Fc. Radiation dosimetry extrapolations to human adults were obtained from mouse biodistribution data according to established methodologies and additional assumptions concerning the impact of the tumor antigenic sink in the cross-species translation.Results[111In]CHX-DTPA-scFv78-Fc was obtained with a radiochemical purity > 98 % after 1 h incubation at 42 °C and ultrafiltration. It showed good stability in human serum and > 70 % immunoreactive fraction. Biodistribution data acquired in tumor-bearing mice confirmed fast blood clearance and specific tumor targeting in both xenograft models. The radiopharmaceutical off-target uptake was predominantly abdominal. After a theoretical injection of [111In]CHX-DTPA-scFv78-Fc to the reference person, the organs receiving the highest absorbed dose would be the spleen (0.876 mGy/MBq), the liver (0.570 mGy/MBq) and the kidneys (0.298 mGy/MBq). The total body dose and the effective dose would be 0.058 mGy/MBq and 0.116 mSv/MBq, respectively.Conclusions[111In]CHX-DTPA-scFv78-Fc binds specifically to endosialin/TEM1in vitroandin vivo. Dosimetry estimates are in the range of other monoclonal antibodies radiolabeled with indium-111. [111In]CHX-DTPA-scFv78-Fc could be potentially translated into clinic.
Is it meaningful to distinguish between Facebook addiction and social networking sites addiction? Psychometric analysis of Facebook addiction and social networking sites addiction scales
Authors: Balcerowska Julia M. , Bereznowski Piotr , Biernatowska Adriana , Atroszko Paweł A. , Pallesen Ståle , Andreassen Cecilie Schou 
Published: January 2020

AbstractStudies conducted on Social Networking Sites (SNSs) addiction have to a large extent focused on Facebook as a prototypical example of SNS. Nonetheless, the evolution of SNSs has spawn conceptual and methodological controversies in terms of the operationalization of SNS addiction. In order to bring more clarity to this field the present study aimed to investigate the construct validity of the Bergen Social Media Addiction Scale (BSMAS) in comparison to the Bergen Facebook Addiction Scale (BFAS) among 1099 young subjects (146 Facebook-only users and 953 who had an account on Facebook and at least one additional SNS). Furthermore, the study aimed to investigate the unique contribution of SNS addiction to stress and general well-being above and beyond personality characteristic and Facebook addiction specifically. Participants completed a survey assessing SNS addiction, Facebook addiction, demography, Big Five personality traits, perceived stress, and general subjective well-being. BSMAS had acceptable fit with the data and demonstrated good reliability. Results showed that the scores of BSMAS were strongly associated with those of BFAS and that the relationship between the two measures was stronger in the group of Facebook-only users than in the group of multisite-social networkers. Moreover, SNS addiction was positively associated with perceived stress and negatively associated with subjective well-being after controlling for Facebook addiction and other study variables. Theoretical and methodological implications of the findings are discussed.
Prevalence and antibiotic resistance of rectal Mollicutes in HIV-infected men who have sex with men at the University Hospital of Dresden, Germany
Authors: Spornraft-Ragaller Petra , Dumke Roger 
Published: January 2020

Abstract
Background
Rectal sexually transmitted infections (STI) are common in men having sex with men (MSM). Mycoplasma genitalium is increasingly being reported in this localization, but due to frequent lack of symptoms at this site, clinical significance is still unclear. Rectal prevalence of Mycoplasma hominis and Ureaplasma species is not well studied so far. We aimed to investigate the prevalence and antibiotic sensitivity of rectal Mollicutes in our HIV-cohort.

Methods
In 227 MSM presenting for annual STI-screening, 317 anorectal swabs were collected from January 2017 to December 2018. PCR was performed for detection of Chlamydia trachomatis, Neisseria gonorrhoeae, M. genitalium and also culture for M. hominis and Ureaplasma spec.

Results
Prevalence for M. genitalium, M. hominis, Ureaplasma spec., C. trachomatis and N. gonorrhoeae was 8.2%, 7.3%, 12.0%, 5.1% and 1.9%, respectively. Patients were asymptomatic with few exceptions. Seroprevalence of syphilis in 227 MSM was 41.9%. In 20 strains of M. genitalium, resistance-associated mutations to macrolides and quinolones were found in 60% and 30%, respectively; in five strains (25%) to both. M. hominis and Ureaplasma spec. frequently occurred combined, mostly in significant quantity consistent with infection. M. hominis and Ureaplasma spec. regularly showed sensitivity to tetracycline.

Conclusion
At screening, rectal colonization with Mollicutes was common in our patients, but rarely caused symptoms. Due to rising antibiotic resistance of M. genitalium against quinolones, therapeutic options are increasingly limited. Treatment should be guided by antibiotic resistance testing including quinolones. In persisting anorectal symptoms, M. hominis and Ureaplasma spec. should also be taken into account.
Not all Speed-Accuracy Trade-Off Manipulations Have the Same Psychological Effect
Authors: Katsimpokis Dimitris , Hawkins Guy E. , van Maanen Leendert 
Published: January 2020

AbstractIn many domains of psychological research, decisions are subject to a speed-accuracy trade-off: faster responses are more often incorrect. This trade-off makes it difficult to focus on one outcome measure in isolation – response time or accuracy. Here, we show that the distribution of choices and response times depends on specific task instructions. In three experiments, we show that the speed-accuracy trade-off function differs between two commonly used methods of manipulating the speed-accuracy trade-off: Instructional cues that emphasize decision speed or accuracy and the presence or absence of experimenter-imposed response deadlines. The differences observed in behavior were driven by different latent component processes of the popular diffusion decision model of choice response time: instructional cues affected the response threshold, and deadlines affected the rate of decrease of that threshold. These analyses support the notion of an “urgency” signal that influences decision-making under some time-critical conditions, but not others.
MakeHub: Fully Automated Generation of UCSC Genome Browser Assembly Hubs
Authors: Hoff Katharina Jasmin 
Published: January 2020

Abstract
Novel genomes are today often annotated by small consortia or individuals whose background is not from bioinformatics. This audience requires tools that are easy to use. Such need has been addressed by several genome annotation tools and pipelines. Visualizing resulting annotation is a crucial step of quality control. The UCSC Genome Browser is a powerful and popular genome visualization tool. Assembly Hubs, which can be hosted on any publicly available web server, allow browsing genomes via UCSC Genome Browser servers. The steps for creating custom Assembly Hubs are well documented and the required tools are publicly available. However, the number of steps for creating a novel Assembly Hub is large. In some cases, the format of input files needs to be adapted, which is a difficult task for scientists without programming background. Here, we describe MakeHub, a novel command line tool that generates Assembly Hubs for the UCSC Genome Browser in a fully automated fashion. The pipeline also allows extending previously created Hubs by additional tracks. MakeHub is freely available for downloading at https://github.com/Gaius-Augustus/MakeHub.
Interpreting the Subsurface Lithofacies at High Lithological Resolution by Integrating Information From Well‐Log Data and Rock‐Core Digital Images
Authors: Jeong Jina , Park Eungyu , Emelyanova Irina , Pervukhina Marina , Esteban Lionel , Yun Seong‐Taek 
Published: January 2020

AbstractSpectral facies interpretation and classification methods have been proposed to improve the sophistication of interpretation of the subsurface heterogeneity. In the spectral facies interpretations, the intensity values of the RGB spectrum and the local entropy from rock‐core digital images are used, and the results are compared to conventional electrofacies and expert petrophysical interpretations. During the classification, a practically applicable model that identifies the more detailed types of lithofacies is constructed by using a multilayer neural network model, with the interpreted spectral facies and well‐log data from the corresponding depths used as response and explanatory variables, respectively. Core digital images and five types of well‐log data from the Satyr 5 well in Western Australia are applied for the actual implementation. Through comparative interpretations, three spectral facies are identified as separable lithofacies (i.e., shale, shaly‐sandstone, and sandstone lithofacies), which is supported by detailed HyLogger mineralogy along the tested cores. On the other hand, two electrofacies (i.e., shale‐dominant and sand‐dominant facies) are identified by a conventional method. In the classification based on the spectral facies, the trained multilayer neural network model showed high prediction accuracy for all the lithofacies. Based on these observations, it is confirmed that more precise lithofacies interpretation and classification can be conducted with the developed methods. The developed methods have the potential to improve subsurface characterization when high lithological resolution is essential.
When Do Complex Transport Dynamics Arise in Natural Groundwater Systems?
Authors: Wu J. , Lester D. R. , Trefry M. G. , Metcalfe G. 
Published: January 2020

AbstractIn a recent paper (Trefry et al., 2019, https://doi.org/10.1029/2018wr023864), we showed that the interplay of aquifer heterogeneity and poroelasticity can produce complex transport in tidally forced aquifers, with significant implications for solute transport, mixing, and reaction. However, what was unknown was how broadly these transport dynamics can arise in natural groundwater systems and how these dynamics depend upon the aquifer properties and tidal and regional flow characteristics. In this study we answer these questions through parametric studies of these governing properties. We uncover the mechanisms that govern complex transport dynamics and the bifurcations between transport structures that depend upon changes in the governing parameters, and we determine the propensity for complex dynamics to occur in natural aquifer systems. These results clearly demonstrate that complex transport structures and dynamics may arise in natural tidally forced aquifers around the world, producing solute transport and mixing behavior that is very different to that of the conventional Darcy flow picture.
Effectiveness and cost-effectiveness of The Daily Mile on childhood weight outcomes and wellbeing: a cluster randomised controlled trial
Authors: Breheny Katie , Passmore Sandra , Adab Peymane , Martin James , Hemming Karla , Lancashire Emma R. , Frew Emma 
Published: January 2020

Abstract
Background
The Daily Mile is designed to increase physical activity levels with children running or walking around school grounds for 15-min daily. It has been adopted by schools worldwide and endorsed as a solution to tackle obesity, despite no robust evidence of its benefits. We conducted a cluster randomised controlled trial to determine its clinical and cost-effectiveness.

Methods
Forty schools were randomly assigned (1:1) to either the Daily Mile intervention or control group in which only the usual school health and wellbeing activities were implemented. The primary outcome was BMI z-score (BMIz) at 12 months follow-up from baseline, with planned subgroup analysis to examine differential effects. Primary economic analysis outcome was incremental cost per Quality-Adjusted-Life-Year (QALY) gained.

Results
Using a constrained randomisation approach, balanced on school size, baseline BMIz and proportion of pupils eligible for free school meals, 20 schools were allocated to intervention (n = 1,153 participants) and 20 to control (n = 1,127); 3 schools withdrew (2 intervention, 1 control). At 12 months, BMIz data were available for 18 intervention schools (n = 850) and 19 control schools (n = 820 participants). Using intention-to-treat analysis the adjusted mean difference (MD) in BMIz (intervention − control) was −0.036 (95% CI: −0.085 to 0.013, p = 0.146). Pre-specified subgroup analysis showed a significant interaction with sex (p = 0.001) suggesting a moderate size benefit of The Daily Mile in girls (MD −0.097, 95% CI −0.156 to −0.037). This was consistent with the exploratory economic results that showed The Daily Mile to be highly cost-effective in girls (£2,492 per QALY), but not in boys, and overall to have a 76% chance of cost-effectiveness for the whole sample, at the commonly applied UK threshold of £20,000 per QALY.

Conclusions
Overall the Daily Mile had a small but non-significant effect on BMIz, however, it had a greater effect in girls suggesting that it might be considered as a cost-effective component of a system-wide approach to childhood obesity prevention.
Multiscale landscape genetics of American marten at their southern range periphery
Authors: Aylward Cody M. , Murdoch James D. , Kilpatrick C. William 
Published: January 2020

AbstractAmerican marten (Martes americana) are a conservation priority in many forested regions of North America. Populations are fragmented at the southern edge of their distribution due to suboptimal habitat conditions. Facilitating gene flow may improve population resilience through genetic and demographic rescue. We used a multiscale approach to estimate the relationship between genetic connectivity and landscape characteristics among individuals at three scales in the northeastern United States: regional, subregional, and local. We integrated multiple modeling techniques and identified top models based on consensus. Top models were used to parameterize resistance surfaces at each scale, and circuit theory was used to identify potential movement corridors. Regional gene flow was affected by forest cover, elevation, developed land cover, and slope. At subregional and local scales, the effects were site specific and included subsets of temperature, elevation, developed land cover, and slope. Developed land cover significantly affected gene flow at each scale. At finer scales, lack of variance in forest cover may have limited the ability to detect a relationship with gene flow. The effect of slope on gene flow was positive or negative, depending on the site examined. Occupancy probability was a relatively poor predictor, and we caution its use as a proxy for landscape resistance. Our results underscore the importance of replication and multiscale approaches in landscape genetics. Climate warming and landscape conversion may reduce the genetic connectivity of marten populations in the northeastern United States, and represent the primary challenges to marten conservation at the southern periphery of their range.
Efficient symmetry-preserving state preparation circuits for the variational quantum eigensolver algorithm
Authors: Gard Bryan T. , Zhu Linghua , Barron George S. , Mayhall Nicholas J. , Economou Sophia E. , Barnes Edwin 
Published: January 2020

AbstractThe variational quantum eigensolver is one of the most promising approaches for performing chemistry simulations using noisy intermediate-scale quantum (NISQ) processors. The efficiency of this algorithm depends crucially on the ability to prepare multi-qubit trial states on the quantum processor that either include, or at least closely approximate, the actual energy eigenstates of the problem being simulated while avoiding states that have little overlap with them. Symmetries play a central role in determining the best trial states. Here, we present efficient state preparation circuits that respect particle number, total spin, spin projection, and time-reversal symmetries. These circuits contain the minimal number of variational parameters needed to fully span the appropriate symmetry subspace dictated by the chemistry problem while avoiding all irrelevant sectors of Hilbert space. We show how to construct these circuits for arbitrary numbers of orbitals, electrons, and spin quantum numbers, and we provide explicit decompositions and gate counts in terms of standard gate sets in each case. We test our circuits in quantum simulations of the $${H}_{2}$$

H

2

and $$LiH$$

L
i
H

molecules and find that they outperform standard state preparation methods in terms of both accuracy and circuit depth.
Estradiol/GPER affects the integrity of mammary duct-like structures in vitro
Authors: Deng Yu , Miki Yoshio , Nakanishi Akira 
Published: January 2020

AbstractHigh estrogen concentration leads to an inflammatory reaction in the mammary gland tissuein vivo; however, the detailed mechanism underlying its specific effects on the breast duct has not been fully clarified. We used 3D-cultured MCF-10A acini as a breast duct model and demonstrated various deleterious effects of 17-β estradiol (E2), including the destruction of the basement membrane surrounding the acini, abnormal adhesion between cells, and cell deathviaapoptosis and pyroptosis. Moreover, we clarified the mechanism underlying these phenomena: E2 binds to GPER in MCF-10A cells and stimulates matrix metalloproteinase 3 (MMP-3) and interleukin-1β (IL-1β) secretionviaJNK and p38 MAPK signaling pathways. IL-1β activates the IL-1R1 signaling pathway and induces continuous MMP-3 and IL-1β secretion. Collectively, our novel findings reveal an important molecular mechanism underlying the effects of E2 on the integrity of duct-like structuresin vitro. Thus, E2 may act as a trigger for ductal carcinoma transitionin situ.
AMPA receptor deletion in developing MGE-derived hippocampal interneurons causes a redistribution of excitatory synapses and attenuates postnatal network oscillatory activity
Authors: Akgül Gülcan , McBain Chris J. 
Published: January 2020

AbstractInhibitory interneurons derived from the medial ganglionic eminence represent the largest cohort of GABAergic neurons in the hippocampus. In the CA1 hippocampus excitatory synapses onto these cells comprise GluA2-lacking, calcium-permeable AMPARs. Although synaptic transmission is not established until early in their postnatal life, AMPARs are expressed early in development, however their role is enigmatic. Using the Nkx2.1-cre mouse line we genetically deleted GluA1, GluA2, GluA3 selectively from MGE derived interneurons early in development. We observed that the number of MGE-derived interneurons was preserved in mature hippocampus despite early elimination of AMPARs, which resulted in >90% decrease in spontaneous excitatory synaptic activity. Of particular interest, excitatory synaptic sites were shifted from dendritic to somatic locations while maintaining a normal NMDAR content. The developmental switch of NMDARs from GluN2B-containing early in development to GluN2A-containing on maturation was similarly unperturbed despite the loss of AMPARs. Early network giant depolarizing potential oscillatory activity was compromised in early postnatal days as was both feedforward and feedback inhibition onto pyramidal neurons underscoring the importance of glutamatergic drive onto MGE-derived interneurons for hippocampal circuit function.