bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of environmental condition on the creation of organic compounds in Pinus sylvestris L. rhizosphere, roots and needles
Authors: Magdziak Zuzanna , Gąsecka Monika , Waliszewska Bogusława , Zborowska Magdalena , Mocek Andrzej , Cichy Wojciech J. , Mazela Bartłomiej , Kozubik Tomisław , Mocek-Płóciniak Agnieszka , Niedzielski Przemysław , Goliński Piotr , Mleczek Mirosław 
Published: October 2020

Abstract
Key message
Studied organic molecules in Pinus sylvestris L. seem to have acted as a safety net for metal transport, chelation and sequestration, allowing adaptation and growth under highly polluted conditions.

Abstract
Pinus sylvestris L. is known for its ability to survive in areas of highly elevated metal pollution, such as flotation tailings. The aim of the study was to estimate the content of selected organic molecules (including aliphatic low molecular weight organic acids (ALMWOAs), phenolic compounds and terpenes) and the physiological mechanisms underlying differences in metal/metalloid tolerance of P. sylvestris growing in unpolluted (soil) and polluted (flotation tailings) areas. The dominant ALMWOAs in rhizosphere soil extracts were citric acid followed by malic and oxalic acids, whereas in flotation tailings malic and oxalic acids. In roots and needles, the content of ALMOWAs was significantly higher in P. sylvestris L. tissue from flotation tailings in comparison to soil. Phenolic compounds were detected only in roots and needles, with a generally higher content of nearly all detected compounds from flotation tailings. The composition of roots did not contain all the compounds detected in needles. The profile of needles additionally contained four hydroxybenzoic, protocatechuic and salicylic acids. In pine needles, 24 volatile terpenes were identified in total. The content of these compounds in pine needles from the polluted area was markedly different from the unpolluted area. The dominant volatile monoterpenes in P. sylvestris L. needles from the unpolluted area was three carene, while in pine needles from the polluted area monoterpenes α-pinene was dominant.
Geomechanical characterisation of organic-rich calcareous shale using AFM and nanoindentation
Authors: Graham S. P. , Rouainia M. , Aplin A. C. , Cubillas P. , Fender T. D. , Armitage P. J. 
Published: October 2020

AbstractThe geomechanical integrity of shale overburden is a highly significant geological risk factor for a range of engineering and energy-related applications including CO$$_2$$

2

storage and unconventional hydrocarbon production. This paper aims to provide a comprehensive set of high-quality nano- and micro-mechanical data on shale samples to better constrain the macroscopic mechanical properties that result from the microstructural constituents of shale. We present the first study of the mechanical responses of a calcareous shale over length scales of 10 nm to 100 $$\upmu$$
μ
m, combining approaches involving atomic force microscopy (AFM), and both low-load and high-load nanoindentation. PeakForce quantitative nanomechanical mapping AFM (PF-QNM) and quantitative imaging (QI-AFM) give similar results for Young’s modulus up to 25 GPa, with both techniques generating values for organic matter of 5–10 GPa. Of the two AFM techniques, only PF-QNM generates robust results at higher moduli, giving similar results to low-load nanoindentation up to 60 GPa. Measured moduli for clay, calcite, and quartz-feldspar are $$22 \pm 2\,\hbox { GPa}$$

22
±
2

GPa

, $$42 \pm 8\,\hbox { GPa}$$

42
±
8

GPa

, and $$55 \pm 10\,\hbox { GPa}$$

55
±
10

GPa

respectively. For calcite and quartz-feldspar, these values are significantly lower than measurements made on highly crystalline phases. High-load nanoindentation generates an unimodal mechanical response in the range of 40–50 GPa for both samples studied here, consistent with calcite being the dominant mineral phase. Voigt and Reuss bounds calculated from low-load nanoindentation results for individual phases generate the expected composite value measured by high-load nanoindentation at length scales of 100–600 $$\upmu$$
μ
m. In contrast, moduli measured on more highly crystalline mineral phases using data from literature do not match the composite value. More emphasis should, therefore, be placed on the use of nano- and micro-scale data as the inputs to effective medium models and homogenisation schemes to predict the bulk shale mechanical response.
Thrombotic Complications in Patients with COVID-19: Pathophysiological Mechanisms, Diagnosis, and Treatment
Authors: Gąsecka Aleksandra , Borovac Josip A. , Guerreiro Rui Azevedo , Giustozzi Michela , Parker William , Caldeira Daniel , Chiva-Blanch Gemma 
Published: October 2020

Abstract
Introduction
Emerging evidence points to an association between severe clinical presentation of COVID-19 and increased risk of thromboembolism. One-third of patients hospitalized due to severe COVID-19 develops macrovascular thrombotic complications, including venous thromboembolism, myocardial injury/infarction and stroke. Concurrently, the autopsy series indicate multiorgan damage pattern consistent with microvascular injury.

Prophylaxis, diagnosis and treatment
COVID-19 associated coagulopathy has distinct features, including markedly elevated D-dimers concentration with nearly normal activated partial thromboplastin time, prothrombin time and platelet count. The diagnosis may be challenging due to overlapping features between pulmonary embolism and severe COVID-19 disease, such as dyspnoea, high concentration of D-dimers, right ventricle with dysfunction or enlargement, and acute respiratory distress syndrome. Both macro- and microvascular complications are associated with an increased risk of in-hospital mortality. Therefore, early recognition of coagulation abnormalities among hospitalized COVID-19 patients are critical measures to identify patients with poor prognosis, guide antithrombotic prophylaxis or treatment, and improve patients’ clinical outcomes.

Recommendations for clinicians
Most of the guidelines and consensus documents published on behalf of professional societies focused on thrombosis and hemostasis advocate the use of anticoagulants in all patients hospitalized with COVID-19, as well as 2-6 weeks post hospital discharge in the absence of contraindications. However, since there is no guidance for deciding the intensity and duration of anticoagulation, the decision-making process should be made in individual-case basis.

Conclusions
Here, we review the mechanistic relationships between inflammation and thrombosis, discuss the macrovascular and microvascular complications and summarize the prophylaxis, diagnosis and treatment of thromboembolism in patients affected by COVID-19.
Determinants and predictors for the long-term disease burden of intracranial meningioma patients
Authors: Zamanipoor Najafabadi Amir H. , van der Meer Pim B. , Boele Florien W. , Taphoorn Martin J. B. , Klein Martin , Peerdeman Saskia M. , van Furth Wouter R. , Dirven Linda ,   on behalf of the Dutch Meningioma Consortium, Boele Florien W. , Dirven Linda , van Furth Wouter R. , Klein Martin , Koekkoek Johan , Lagerwaard Frank , van der Meer Pim B. , Peerdeman Saskia M. , Taphoorn Martin J. B. , Zamanipoor Najafabadi Amir H. , Moojen Wouter A. , Reijneveld Jaap C. 
Published: October 2020

Abstract
Introduction
Meningioma is a heterogeneous disease and patients may suffer from long-term tumor- and treatment-related sequelae. To help identify patients at risk for these late effects, we first assessed variables associated with impaired long-term health-related quality of life (HRQoL) and impaired neurocognitive function on group level (i.e. determinants). Next, prediction models were developed to predict the risk for long-term neurocognitive or HRQoL impairment on individual patient-level.

Methods
Secondary data analysis of a cross-sectional multicenter study with intracranial WHO grade I/II meningioma patients, in which HRQoL (Short-Form 36) and neurocognitive functioning (standardized test battery) were assessed. Multivariable regression models were used to assess determinants for these outcomes corrected for confounders, and to build prediction models, evaluated with C-statistics.

Results
Data from 190 patients were analyzed (median 9 years after intervention). Main determinants for poor HRQoL or impaired neurocognitive function were patients’ sociodemographic characteristics, surgical complications, reoperation, radiotherapy, presence of edema, and a larger tumor diameter on last MRI. Prediction models with a moderate/good ability to discriminate between individual patients with and without impaired HRQoL (C-statistic 0.73, 95% CI 0.65 to 0.81) and neurocognitive function (C-statistic 0.78, 95%CI 0.70 to 0.85) were built. Not all predictors (e.g. tumor location) within these models were also determinants.

Conclusions
The identified determinants help clinicians to better understand long-term meningioma disease burden. Prediction models can help early identification of individual patients at risk for long-term neurocognitive or HRQoL impairment, facilitating tailored provision of information and allocation of scarce supportive care services to those most likely to benefit.
Developing inclusive education in Portugal: Evidence and challenges
Authors: Alves Ines , Campos Pinto Paula , Pinto Teresa Janela 
Published: October 2020

AbstractThis article assesses evidence of and challenges to the development of inclusive education in Portugal, which is built on three pillars: access to, participation in, and achievement in education for all children and young people. It presents an overview of the present policy framework, followed by an analysis of available statistical data on Portuguese students with disabilities in mainstream schools. The article also discusses significant achievements at the policy and practice levels, namely the attempt to align curriculum and pedagogy and the presence of almost 100% of students with disabilities in mainstream schools. It also considers challenges, such as the issue of monitoring achievement (both at the student and system level) and investments in the system and in teacher education.
Observations of the Solar Corona from Space
Authors: Antonucci Ester , Harra Louise , Susino Roberto , Telloni Daniele 
Published: October 2020

AbstractSpace observations of the atmosphere of the Sun, obtained in half a century of dedicated space missions, provide a well established picture of the medium and large-scale solar corona, which is highly variable with the level of solar activity through a solar cycle and evolves with the long-term evolution of the magnetic cycles. In this review, we summarize the physical properties and dynamics of the medium and large-scale corona, consisting primarily of active regions, streamers and coronal holes; describe the dependence of coronal patterns on the magnetic field patterns changing through the solar cycle and the properties of the regions of open magnetic flux channeling the solar wind; the ubiquitous presence of fluctuations in the outer corona; the rotational properties of the large-scale corona; and the persistent hemispheric asymmetries in the emergence of magnetic fields and the distribution of the coronal emission.
Precision medicine in acute lymphoblastic leukemia
Authors: Pui Ching-Hon 
Published: October 2020

AbstractThe cure rate of childhood acute lymphoblastic leukemia (ALL) has exceeded 90% in some contemporary clinical trials. However, the dose intensity of conventional chemotherapy has been pushed to its limit. Further improvement in outcome will need to rely more heavily on molecular therapeutic as well as immuno-and cellular-therapy approaches together with precise risk stratification. Children with ETV6-RUNX1 or hyperdiploid > 50 ALL who achieve negative minimal residual disease during early remission induction are suitable candidates for reduction in treatment. Patients with Philadelphia chromosome (Ph)-positive or Ph-like ALL with ABL-class fusion should be treated with dasatinib. BH3 profiling and other preclinical methods have identified several high-risk subtypes, such as hypodiplod, early T-cell precursor, immature T-cell, KMT2A-rearranged, Ph-positive and TCF-HLF-positive ALL, that may respond to BCL-2 inhibitor venetoclax. There are other fusions or mutations that may serve as putative targets, but effective targeted therapy has yet to be established. For other high-risk patients or poor early treatment responders who do not have targetable genetic lesions, current approaches that offer hope include blinatumomab, inotuzumab and CAR-T cell therapy for B-ALL, and daratumumab and nelarabine for T-ALL. With the expanding therapeutic armamentarium, we should start focus on rational combinations of targeted therapy with non-overlapping toxicities.
Kann Jungenarbeit queer sein?
Authors: Rieske Thomas Viola 
Published: October 2020

ZusammenfassungDas Konzept queer steht für die Kritik geschlechts- und sexualitätsbezogener Normen, sofern diese gesellschaftliche Marginalisierungen begründen. Für die geschlechterreflektierte Pädagogik mit Jungen – kurz: Jungenarbeit – bietet es eine Reflexionsperspektive, mit der Annahmen über Jungen hinterfragt werden können. Sie stärkt Jungenarbeit darin, sich an den vielfältigen Bedürfnissen und Problemlagen von Jungen zu orientieren und dabei Jungen wie auch Pädagog_innen von unnötigen normativen Erwartungen zu entlasten.
Effect of Amount of DNA on Digital PCR Assessment of Genetically Engineered Canola and Soybean Events
Authors: Demeke Tigst , Eng Monika , Holigroski Michelle , Lee Sung-Jong 
Published: October 2020

AbstractLow-level detection and quantification of genetically engineered (GE) traits with polymerase chain reaction (PCR) is challenging. For unapproved GE events, any level of detection is not acceptable in some countries because of zero tolerance. Droplet digital PCR (ddPCR) has been successfully used for absolute quantification of GE events. In this study, reliability of low level quantification of GE events with ddPCR was assessed using a total of 50, 100, 200, 400, and 600 ng DNA spiked at 0.01% and 0.1% concentration levels. Genetically engineered canola (GT73 and MON88302 events) and soybean (A2704-12 and DP305423 events) events were used for the study. For samples spiked at 0.1% level, reliable quantification was achieved for the four GE events using 50 or 100 ng DNA. Few target droplets were generated for 0.01% spiked GE samples using 50 and 100 ng DNA. Increasing the amount of DNA for ddPCR generated more number of target droplets. For GE canola events, the use of 400 and 600 ng DNA for ddPCR resulted in saturation. The use of multiple wells of 200 ng DNA (instead of 400 and 600 ng per well) helped to overcome the saturation problem. Overall, the use of high amount of DNA for ddPCR was helpful for the detection and quantification of 0.01% GE samples.
Informed preference consequentialism, contractarianism and libertarian paternalism: on Harsanyi, Rawls and Robert Sugden’s The Community of Advantage
Authors: Qizilbash Mozaffar 
Published: October 2020

AbstractRobert Sugden abandons certain central tenets of traditional welfare economics and recommends a contractarian alternative. He rejects ‘Libertarian Paternalism’ (LP) and related ‘paternalistic’ proposals. The seeds of ‘paternalism’ inspired by the findings of behavioural economics can be found in informed preference views associated with J.S. Mill and John Harsanyi. Nonetheless, those who endorse a combination of the informed preference view of welfare, consequentialism and welfarism—‘informed preference consequentialists’—have good reasons to resist the agenda of LP. John Rawls adopts a variation of the informed preference view. Contracting parties in his theory accept ‘paternalistic principles’. Sugden’s claim that contractarians cannot be ‘paternalists’ does not generalise to all contractarian theories. Sugden’s and Rawls’ contractarian positions are in important respects different.
Nuclear global spaces of ultradifferentiable functions in the matrix weighted setting
Authors: Boiti Chiara , Jornet David , Oliaro Alessandro , Schindl Gerhard 
Published: October 2020

AbstractWe prove that the Hermite functions are an absolute Schauder basis for many global weighted spaces of ultradifferentiable functions in the matrix weighted setting and we determine also the corresponding coefficient spaces, thus extending the previous work by Langenbruch. As a consequence, we give very general conditions for these spaces to be nuclear. In particular, we obtain the corresponding results for spaces defined by weight functions.
Freerolls and binds: making policy when information is missing
Authors: DUKE ANNIE , SUNSTEIN CASS R. 
Published: October 2020

AbstractWhen policymakers focus on costs and benefits, they often find that hard questions become easy – as, for example, when the benefits clearly exceed the costs, or when the costs clearly exceed the benefits. In some cases, however, benefits or costs are difficult to quantify, perhaps because of limitations in scientific knowledge. In extreme cases, policymakers are proceeding in circumstances of uncertainty rather than risk, in the sense that they cannot assign probabilities to various outcomes. We suggest that in difficult cases in which important information is absent, it is useful for policymakers to consider a concept from poker: ‘freerolls.’ A freeroll exists when choosers can lose nothing from selecting an option but stand to gain something (whose magnitude may itself be unknown). In some cases, people display ‘freeroll neglect.’ In terms of social justice, John Rawls’ defense of the difference principle is grounded in the idea that, behind the veil of ignorance, choosers have a freeroll. In terms of regulatory policy, one of the most promising defenses of the Precautionary Principle sees it as a kind of freeroll. Some responses to climate change, pandemics and financial crises can be seen as near-freerolls. Freerolls and near-freerolls must be distinguished from cases involving cumulatively high costs and also from faux freerolls, which can be found when the costs of an option are real and significant, but not visible. ‘Binds’ are the mirror-image of freerolls; they involve options from which people are guaranteed to lose something (of uncertain magnitude). Some regulatory options are binds, and there are faux binds as well.
Cash transfer and professional care for tackling child poverty and neglect in Italy
Authors: Bezze Maria , Canali Cinzia , Geron Devis , Vecchiato Tiziano 
Published: October 2020

AbstractThere has been a general increase in poverty over the last decade in Italy, which has mainly affected the younger generations, with children and youth experiencing the worst economic conditions. This is primarily not due to a lack of available economic resources but to the way in which these resources are allocated: mainly in the form of cash transfers rather than services. The provision of adequate services based on professional work needs to be implemented by overcoming two main obstacles which are highlighted by the results of two studies presented here. The first study concerns the quality of professional care and the systematic use of outcome evaluation, the second concerns the vision of professionals and their ability to integrate the provision of services with economic support aimed at improving children’s growth and parenting skills. The two studies were carried out as part of an international debate on how to effectively fight poverty and social exclusion of children which was promoted by the International Association for Outcome-based Evaluation and Research on Family and Children’s Services (iaOBERfcs).
Milestones and Directions: Socio-Legal Studies in Germany and the United Kingdom
Authors: Machura Stefan 
Published: October 2020

AbstractUnder the headings of “Rechtssoziologie” in Germany and “sociolegal studies” in the UK, scholarly traditions have developed that relate law to its social environment. This Article identifies key stages in the development the subject took in both countries and the directions of travel. Comparable milestones were passed, and directions were taken in Germany and the UK. This includes the institutionalization of the subject along the lines of programmatic texts; becoming part of university education; and the establishment of research institutes, academic associations, and specialized journals. The development tells us something beyond sociology of law or sociolegal studies, namely about the relation of law and sociology, the parent disciplines themselves, as well as about academic studies and professional and institutional practice. However, in contrast to the UK, there is still more of a distance between the sociology of law and jurisprudence in Germany.
The Left and universal basic income: the role of ideology in individual support
Authors: Schwander Hanna , Vlandas Tim 
Published: October 2020

AbstractFew studies to date have analysed individual support for universal basic income (UBI). This article theorizes and explores empirically the relationship between different strands of left ideology and support for UBI across European countries. We delineate three types of concerns about capitalism: “Labourist Left” worry aboutexploitation; “Libertarian Left” aboutrepressionand “Social Investment Left” aboutinefficiencies. Contrary to expectations we derive from political theory and welfare state literature, our results based on data from the European Social Survey suggest that having high concerns about exploitation is positively correlated with support for UBI, whereas repression concerns are negatively correlated with support. In line with our hypothesis about social investment ideology, left-leaning individuals with efficiency concerns are more likely to support UBI. Our findings call for more detailed surveys as well as further research on the different ideologies within the Left and how these relate to variation in support for UBI, which crucially shapes the potential political coalition behind the introduction of UBI.
The Role of Disability and Accessibility in Corporate Sustainability Reporting
Authors: Vogelauer Christian , Herold David M. , Fuerst Elmar 
Published: October 2020

Abstract
Although companies increasingly focus on the social dimension in corporate sustainability, there seems to be a lack of understanding how and to what extent disability and accessibility frameworks and activities are integrated in corporate sustainability reports. In this article, we aim to close this gap by (a) analysing the disability and accessibility (D&A) activities from the largest 50 companies in Europe based on their corporate sustainability reports, and (b) advancing a simplified conceptual framework for D&A that can be used in corporate reporting. In particular, we provide an overview about corporate D&A reporting and associated activities according to three identified areas: (a) workforce, (b) workplace, and (c) products and services. Our findings are twofold: First, the majority of the companies address D&A in their corporate sustainability reports mainly under the diversity umbrella, but lack a detailed debate about the three identified areas. Second, we found that existing frameworks for D&A are hardly used because either they are not focused on corporate reporting or seem too difficult or complicated to complete. Thus, our framework not only represents a first opportunity to foster the implementation of a D&A framework within the social dimension of corporate sustainability reports, but also presents a holistic yet flexible management tool that takes into account the most critical elements while shaping implementation, directing evaluation and encouraging future planning of D&A initiatives. As such, this study contributes to and extends the limited amount of research of D&A activities in the social dimension in corporate sustainability reporting.