bluuebunny/crossref_metadata_2025_split huggingface dataset:
Qualitative Analysis of the Coordination of Major System Change Within the Colombian Health System in Response to COVID-19: Study Protocol
Authors: Turner Simon , Niño Natalia 
Published: July 2020

Abstract
Background
Coronavirus (COVID-19) is posing a major and unprecedented challenge to health service planning and delivery across health systems internationally. This nationally-funded study is analysing the response of the Colombian health system to the COVID-19 pandemic, drawing on qualitative case studies of three local health systems within the country. The approach will be informed by the concept of 'major system change' - or coordinated change among a variety of healthcare organisations and other relevant stakeholders - in order to identify processes that both enable and inhibit adaptation of health services to the challenges presented by COVID-19. The study will collect information on capacity “bottlenecks” as well as successful practices and forms of innovation that have emerged locally, which have the potential for being 'scaled up' across Colombia's health services.
Methods/design
This qualitative study will be undertaken in two phases. In the first, up to 30 stakeholder interviews will be conducted to ascertain and share immediate challenges and opportunities for improvement in response to COVID-19 that can be shared in a timely way with health service leaders to inform immediate health service planning. The stakeholders will be selected in order to sample a range of planning, provider and intermediary organizations within the health system at the national level. In the second, up to 60 further interviews will be conducted to develop in-depth case studies of three local health systems at the metropolitan area level within Colombia. The interview data will be supplemented with documentary analysis and, where feasible, non-participant observation of meetings directly related to the planning and implementation of actions responding to COVID-19. The study will also establish mechanisms for providing timely, formative feedback to inform health system planning relating to COVID-19 and future pandemics by ascertaining stakeholders' preferences during the interviews and wider scoping discussions.
Discussion
The study's findings will aid evaluation of the relevance of the concept of major system change in a context of 'crisis' decision-making and contribute to international lessons on improving health systems' capacity to respond to COVID-19 and future pandemics. Study findings will be shared among various stakeholders in the Colombian healthcare system in a formative and timely way in order to inform healthcare planning in response to COVID-19 and future pandemics. Conducting the study at a time of COVID-19 raises a number of practical issues (including physical distancing and pressure on health services) which have been anticipated in the study design and research team's ways of working.
COVID-19 induced encephalopathy – a Case Report
Authors: Abdelnaby Ramy , Elsayed Mohamed , Abele-Haupts Francis , Barkin Mehmet E. , Rudek Markus A. , Schmidt Kai 
Published: July 2020

Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also called coronavirus disease 2019 (COVID-19), first appeared in December 2019 in Wuhan, China. It has rapidly spread to multiple countries and has become a global health problem. The effects of COVID-19 on the CNS (Central Nervous System) are reported in low but increasing numbers. We report a case of COVID-19-induced encephalopathy with a biphasic clinical presentation only after a neurologically silent period.
Identification of Key Regulators Responsible for Dysregulated Networks in Osteoarthritis by Large-Scale Expression Analysis
Authors: Shi Song , Wan Fuyin , Zhou Zhenyu , Tao Ran , Lu Yue , Zhou Ming , Liu Fan , Liu Yake 
Published: July 2020

Abstract
Background: Osteoarthritis (OA) is a worldwide musculoskeletal disorder. However, disease-modifying therapies for OA are not available. Here, we aimed to characterize the molecular signatures of OA and to identify novel therapeutic targets and strategies to improve the treatment of OA.Methods: We collected genome-wide transcriptome data performed on 161 OA and 88 normal human cartilage or synovium tissues from 9 independent datasets. Differential gene expression analysis and functional enrichment were performed to identify genes and pathways that were dysregulated in OA. The computational drug repurposing method was used to uncover drugs that could be repurposed to treat OA.Results: We identified several pathways associated with the development of OA, such as extracellular matrix adhesion, inflammation, carbohydrate metabolism, and collagen organization. By protein-protein interaction (PPI) network analysis, we prioritized several hub genes, such as JUN, IL-6, VAMP8, and SOCS3. Moreover, we repurposed several FDA-approved drugs, such as cardiac glycosides, that could be used in the treatment of OA. Conclusions: We proposed that the hub genes we identified will play a role in cartilage homeostasis and could be important diagnostic and therapeutic targets. Drugs such as protein kinase inhibitors and cardiac glycosides could improve the treatment of OA.
Be-careful! Behind the storm of severe COVID-19, could be hidden macrophage activation syndrome. A case report with excellent outcome.
Authors: Gonçalves Rafaela Silva Guimarães , Victor André da Costa , Tavare Ana Carolina Oliveira Cavalcanti , Duarte Angela Luzia Branco Pinto 
Published: July 2020

Abstract
In severe cases of COVID-19, it is important to note that some laboratory signs may alert to the presence of underlying macrophage activation syndrome (MAS), and we ratify that the classic signs of primary MAS are often not present. Here we show a case report of COVID-19 complicated by MAS treated with high doses of methylprednisolone and intravenous Immunoglobulin, with excellent clinical outcome, avoiding orotracheal intubation indeed. The interpretation of laboratory signs leads to early diagnosis and the introduction of effective therapy.
The accuracy of teleradiologists in diagnosing COVID-19 based on a French multicentric emergency cohort
Authors: Nivet Hubert , Crombé Amandine , Schuster Paul , Ayoub Thomas , Pourriol Laurent , Favard Nicolas , Chazot Alban , Alonzo-Lacroix Florian , Youssof Emile , Cheikh Alexandre Ben , Balique Juien , Porta Basile , Petitpierre François , Bouquet Grégoire , Mastier Charles , Bratan Flavie , Bergerot Jean-François , Thomson Vivien , Banaste Nathan , Gorincour Guillaume 
Published: July 2020

Abstract
Objectives: To evaluate the accuracy of diagnoses of COVID-19 based on chest CT as well as inter-observer agreement between teleradiologists during on-call duty and senior radiologists in suspected COVID-19 patients. Materials and Methods: From 03/13/2020 to 04/14/2020, consecutive suspected COVID-19 adult patients who underwent both an RT-PCR test and chest CT from 15 hospitals were included in this prospective study. Chest CTs were immediately interpreted by the on-call teleradiologist and were systematically blind reviewed by a senior radiologist. Readings were categorised using a five-point scale: (1) normal; (2) non-infectious findings; (3) infectious findings but not consistent with COVID-19 infection; (4) consistent with COVID-19 infection; and (5) typical appearance of COVID-19 infection. The diagnostic accuracy of chest CT and inter-observer agreement using the Kappa coefficient were evaluated over the study period.Results: In total, 513 patients were enrolled, of whom 244/513 (47.6%) tested positive for RT-PCR. First readings were scored 4 or 5 in 225/244 (92%) RT-PCR+ patients, and between 1 and 3 in 201/269 (74.7%) RT-PCR- patients. The data were highly consistent (weighted Kappa=0.87) and correlated with RT-PCR (p<0.001, AUC1st-reading=0.89, AUC2nd-reading=0.93). The negative predictive value for scores of 4 or 5 was 0.91–0.92, and the PPV for a score of 5 was 0.89–0.96 at the first and second readings, respectively. Diagnostic accuracy was consistent over the study period, irrespective of a variable prevalence rate.Conclusion: Chest CT demonstrated high diagnostic accuracy with strong inter-observer agreement between on-call teleradiologists with varying degrees of experience and senior radiologists over the study period.
Experimental dataset and numerical simulation of floating bodies transport in open-channel flow
Authors: Persi Elisabetta , Petaccia Gabriella , Sibilla Stefano , Brufau Pilar , García-Palacin José Ignacio 
Published: July 2020

Abstract
Numerical models trying to faithfully represent the movement of floating bodies transport in open-channel flow require experimental data for validation. In order to provide an adequate dataset, flume experiments were carried out to analyse the transport of singular and grouped rigid bodies floating on the water surface. Both cylindrical and spherical samples were employed: they were released in a rectangular channel under steady conditions in one-dimensional (plain channel) and two-dimensional (2D) configurations using one rectangular side obstacle, one smooth side obstacle or two rectangular alternate obstacles. The outcomes of the experiments are the planar displacement and the rotation of the samples, which are related to the flow field in the different configurations. The detailed experimental analysis of the floating body motion provides information for the calibration of numerical models simulating floating bodies transport. This dataset is thus employed for the validation of the Eulerian–Lagrangian model ORSA2D_WT, highlighting its strengths and improvable aspects. Similar applications could be carried out with any 2D model which performs the simulation of discrete elements moving on the water surface.
Identification of Maple Anthocyanin and its Antiproliferative Activity against LLC, T47D and C3H10T1/2 Cells
Authors: Fujiwara Yumi , Miwa Mako , Nagatsu Akito , Honma Atsushi 
Published: July 2020

Background:
The genus Acer contains around 200 species, with more than 400 garden varieties.
There is considerable diversity in these species and garden varieties, and each can be characterized by morphology
and chemical composition. The red appearance of Acer leaves is due to anthocyanin compounds, including
cyanidin glycosides, delphinidin glycosides, and galloylated anthocyanins. Few studies have investigated the
diversity of anthocyanin compounds in garden varieties, and no studies have examined the pharmacological
effects of these compounds.

Objective:
The purpose of this study was to identify the anthocyanins of Acer palmatum cv. ‘Chishio’, a garden
variety of A. palmatum and evaluate their antiproliferative and antioxidant activities.

Methods:
A methanol extract of fresh leaves was partitioned with ethyl acetate. The extract was purified by
column chromatography and compounds were subsequently identified by 1H and 13C NMR and ESI-HRMS.
Antiproliferative activity was evaluated by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-
sulfophenyl)-2H-tetrazolium, inner salt (MTS) colorimetric assay. The antioxidant assay was evaluated by scavenging
activity using the stable radical DPPH.

Results:
The anthocyanins cyanidin-3-O-(6''-O-α-rhamnopyranosyl- β-glucopyranoside), cyanidin-3-O- β-
glucopyranoside, cyanidin-3-O-[2''-O-(galloyl)-6''-O-(rhamnosyl)-β-glucoside], and cyanidin-3-O-[2''-O-(galloyl)-
β-glucopyranoside] were isolated from A. palmatum cv. ‘Chishio’. All four anthocyanin compounds showed
antiproliferative activity against LLC and T47D cells, and galloylated anthocyanin showed antiproliferative
activity against C3H10T1/2 cells. All four anthocyanins inhibited the activity of DPPH radicals in a dosedependent
manner.

Conclusion:
Maple anthocyanins could be a new cancer therapeutic agent or prophylactic medicine.
Quality of Care Perceived by Older Patients and Caregivers in Integrated Care Pathways With Interviewing Assistance From a Social Robot: Noninferiority Randomized Controlled Trial
Authors: Boumans Roel , van Meulen Fokke , van Aalst William , Albers Joyce , Janssen Marèse , Peters-Kop Marieke , Huisman - de Waal Getty , van de Poll Alexandra , Hindriks Koen , Neerincx Mark , Olde Rikkert Marcel 
Published: July 2020

Background
Society is facing a global shortage of 17 million health care workers, along with increasing health care demands from a growing number of older adults. Social robots are being considered as solutions to part of this problem.

Objective
Our objective is to evaluate the quality of care perceived by patients and caregivers for an integrated care pathway in an outpatient clinic using a social robot for patient-reported outcome measure (PROM) interviews versus the currently used professional interviews.

Methods
A multicenter, two-parallel-group, nonblinded, randomized controlled trial was used to test for noninferiority of the quality of care delivered through robot-assisted care. The randomization was performed using a computer-generated table. The setting consisted of two outpatient clinics, and the study took place from July to December 2019. Of 419 patients who visited the participating outpatient clinics, 110 older patients met the criteria for recruitment. Inclusion criteria were the ability to speak and read Dutch and being assisted by a participating health care professional. Exclusion criteria were serious hearing or vision problems, serious cognitive problems, and paranoia or similar psychiatric problems. The intervention consisted of a social robot conducting a 36-item PROM. As the main outcome measure, the customized Consumer Quality Index (CQI) was used, as reported by patients and caregivers for the outpatient pathway of care.

Results
In total, 75 intermediately frail older patients were included in the study, randomly assigned to the intervention and control groups, and processed: 36 female (48%) and 39 male (52%); mean age 77.4 years (SD 7.3), range 60-91 years. There was no significant difference in the total patient CQI scores between the patients included in the robot-assisted care pathway (mean 9.27, SD 0.65, n=37) and those in the control group (mean 9.00, SD 0.70, n=38): P=.08, 95% CI –0.04 to 0.58. There was no significant difference in the total CQI scores between caregivers in the intervention group (mean 9.21, SD 0.76, n=30) and those in the control group (mean 9.09, SD 0.60, n=35): P=.47, 95% CI –0.21 to 0.46. No harm or unintended effects occurred.

Conclusions
Geriatric patients and their informal caregivers valued robot-assisted and nonrobot-assisted care pathways equally.

Trial Registration
ClinicalTrials.gov NCT03857789; https://clinicaltrials.gov/ct2/show/NCT03857789
Impact of the COVID-19 Pandemic on Partner Relationships and Sexual and Reproductive Health: Cross-Sectional, Online Survey Study
Authors: Li Guanjian , Tang Dongdong , Song Bing , Wang Chao , Qunshan Shen , Xu Chuan , Geng Hao , Wu Huan , He Xiaojin , Cao Yunxia 
Published: July 2020

Background
In the past few months, the coronavirus disease (COVID-19) pandemic has caused extensive economic and social damage.

Objective
The purpose of this study was to assess the impact of COVID-19–related measures on partner relationships and sexual and reproductive health in China.

Methods
From May 1 to 5, 2020, 3500 young Chinese individuals were recruited through WeChat or Weibo to participate in a survey to obtain information on sexual and reproductive health (eg, sexual desire, frequency of sexual intercourse, sexual satisfaction, etc). The questionnaire also collected demographic data (eg, age, race, education, current financial status, sexual orientation, relationship status, etc).

Results
In total, 967 participants were included in the sexual health analysis. Due to the COVID-19 pandemic and related containment measures, 22% of participants (n=212) reported a decrease in sexual desire; 41% (n=396) experienced a decrease in the sexual intercourse frequency; 30% (n=291) reported an increase in the frequency of masturbation; 20% (n=192) reported a decrease in alcohol consumption before or during sexual activities, and 31% (n=298) reported a deterioration in partner relationships during the pandemic. The logistic regression analysis indicated that the following influenced partner relationships: accommodations during the pandemic (P=.046; odds ratio [OR] 0.59; 95% CI 0.30-0.86); exclusive relationship status (yes or no) (P<.001; OR 0.44; 95 % CI 0.27-0.73); sexual desire (P=.02; OR 2.01; 95% CI 1.38-2.97); and sexual satisfaction (P<.001; OR 1.92; 95% CI 1.54-2.50). COVID-19 also caused disruptions in reproductive health services such as prenatal and postnatal care, childbirth and abortion services, contraception availability, and the management of sexually transmitted infections.

Conclusions
Our results show that many young people have wide-ranging issues affecting their sexual and reproductive health due to the COVID-19 pandemic and related containment measures. Strategies and guidelines are needed to safeguard the sexual and reproductive health of young people during this pandemic.
Cross-Country Comparison of Public Awareness, Rumors, and Behavioral Responses to the COVID-19 Epidemic: Infodemiology Study
Authors: Hou Zhiyuan , Du Fanxing , Zhou Xinyu , Jiang Hao , Martin Sam , Larson Heidi , Lin Leesa 
Published: July 2020

Background
Understanding public behavioral responses to the coronavirus disease (COVID-19) epidemic and the accompanying infodemic is crucial to controlling the epidemic.

Objective
The aim of this study was to assess real-time public awareness and behavioral responses to the COVID-19 epidemic across 12 selected countries.

Methods
Internet surveillance was used to collect real-time data from the general public to assess public awareness and rumors (China: Baidu; worldwide: Google Trends) and behavior responses (China: Ali Index; worldwide: Google Shopping). These indices measured the daily number of searches or purchases and were compared with the numbers of daily COVID-19 cases. The trend comparisons across selected countries were observed from December 1, 2019 (prepandemic baseline) to April 11, 2020 (at least one month after the governments of selected countries took actions for the pandemic).

Results
We identified missed windows of opportunity for early epidemic control in 12 countries, when public awareness was very low despite the emerging epidemic. China's epidemic and the declaration of a public health emergency of international concern did not prompt a worldwide public reaction to adopt health-protective measures; instead, most countries and regions only responded to the epidemic after their own case counts increased. Rumors and misinformation led to a surge of sales in herbal remedies in China and antimalarial drugs worldwide, and timely clarification of rumors mitigated the rush to purchase unproven remedies.

Conclusions
Our comparative study highlights the urgent need for international coordination to promote mutual learning about epidemic characteristics and effective control measures as well as to trigger early and timely responses in individual countries. Early release of official guidelines and timely clarification of rumors led by governments are necessary to guide the public to take rational action.
Red Queen in the Repository
Authors: Philipson Joakim 
Published: July 2020

One of the grand curation challenges is to secure metadata quality in the ever-changing environment of metadata standards and file formats. As the Red Queen tells Alice in Through the Looking-Glass: â€œNow, here, you see, it takes all the running you can do, to keep in the same place.â€ That is, there is some â€œrunningâ€ needed to keep metadata records in a research data repository fit for long-term use and put in place. One of the main tools of adaptation and keeping pace with the evolution of new standards, formats â€“ and versions of standards in this ever-changing environment are validation schemas. Validation schemas are mainly seen as methods of checking data quality and fitness for use, but are also important for long-term preservation. We might like to think that our present (meta)data standards and formats are made for eternity, but in reality we know that standards evolve, formats change (some even become obsolete with time), and so do our needs for storage, searching and future dissemination for re-use. Eventually, we come to a point where transformation of our archival records and migration to other formats will be necessary. This could also mean that even if the AIPs, the Archival Information Packages stay the same in storage, the DIPs, the Dissemination Information Packages that we want to extract from the archive are subject to change of format. Further, in order for archival information packages to be self-sustainable, as required in the OAIS model, it is important to take interdependencies between individual files in the information packages into account. This should be done already by the time of ingest and validation of the SIPs, the Submission Information Packages, and along the line at different points of necessary transformation/migration (from SIP to AIP, from AIP to DIP etc.), in order to counter obsolescence.
This paper investigates possible validation errors and missing elements in metadata records from three general purpose, multidisciplinary research data repositories â€“ Figshare, Harvardâ€™s Dataverse and Zenodo, and explores the potential effects of these errors on future transformation to AIPs and migration to other formats within a digital archive.
Strategi Dalam Meningkatkan Kompetensi dan Profesionalisme Pustakawan dalam Mengoptimalkan Kembali Reference Service terhadap Pemustaka di Perpustakaan Universitas Negeri Padang
Authors: Sumitra Falian 
Published: July 2020

ABSTRACT
The reference service at the library is currently less than optimal. Therefore, several strategies are needed to improve the competence and professionalism of librarians in reference services. One of the reference services that still needs optimization in improving the competence of librarians is the Padang State University Library. The method used in this article is a qualitative method with a descriptive approach. This type of research in writing this article uses the Research Library method which means a literature or literature study. The purpose of this research is to find out the strategies used by libraries to improve the competence and professionalism of librarians in reference services and to find out what the obstacles are in the Padang State University Library.
DISCOVERY LEARNING MODEL AS A SOLUTION TO DEVELOP STUDENTS’ UNDERSTANDING IN MATRIX CONCEPT
Authors: Khairunnisa Sri Nadia , Putra Harry Dwi , Senjayawati Eka 
Published: July 2020

Abstract:This study aims to examine the increasing mastery of the concept of the matrix through the Discovery Learning model. This research is a class action research. The subjects in this study were students of Class XI TEDK-A at SMK Negeri 1 Cimahi. Data sources are teachers and students. Data collection techniques using tests and observation sheets. Based on data analysis, the average of student learning outcomes has increased by 77.42, from the first test cycle achieved by 10.00 to the last testing cycle achieved by 87.42. From the results, it can be concluded that there is an improvement in students' mathematical understanding of the matrix material in class XI TEDK-A in SMK Negeri 1 Cimahi students who use the discovery learning model. Abstrak:Penelitian ini bertujuan untuk menguji apakah penguasaan konsep matriks melalui model Discovery Learning dapat ditingkatkan. Jenis penelitian ini adalah penelitian tindakan kelas. Subjek dalam penelitian ini adalah siswa kelas XI TEDK-A di SMK Negeri 1 Cimahi. Sumber data diperoleh dari guru dan siswa. Teknik pengumpulan data menggunakan tes dan lembar observasi. Berdasarkan analisis data, rata-rata hasil belajar siswa meningkat sebesar 77,42 dari siklus tes pertama yang dicapai sebesar 10,00 hingga siklus pengujian terakhir yang dicapai oleh 87,42. Dari hasil penelitian dapat disimpulkan bahwa terdapat peningkatan pemahaman matematis siswa pada materi matriks siswa kelas XI TEDK-A di SMK Negeri 1 Cimahi dengan menggunakan model Discovery Learning.