bluuebunny/crossref_metadata_2025_split huggingface dataset:
A high performance adaptive on-time controlled valley-current-mode DC–DC buck converter
Authors: Jiang Chanrong , Chai Changchun , Han Chenxi , Yang Yintang 
Published: June 2020

Abstract
This paper presents an AOT-controlled (adaptive-on-time, AOT) valley-current-mode buck converter for portable application. The buck converter with synchronous rectifier not only uses valley-current-mode control but also possesses hybrid-mode control functions at the same time. Due to the presence of the zero-current detection circuit, the converter can switch freely between the two operating modes without the need for an external mode selection circuit, which further reduces the design difficulty and chip area. The converter for the application of high power efficiency and wide current range is used to generate the voltage of 0.6–3.0 V with a battery source of 3.3–5.0 V, while the load current range is 0.05–2 A. The circuit can work in continuous conduction mode with constant frequency in high load current range. In addition, a stable output voltage can be obtained with small voltage ripple. In pace with the load current decreases to a critical value, the converter transforms into the discontinuous conduction mode smoothly. As the switching period increases, the switching loss decreases, which can significantly improve the conversion efficiency. The proposed AOT controlled valley current mode buck converter is integrated with standard 0.18 μm process and the simulation results show that the converter provides well-loaded regulations with power efficiency over 95%. When the circuit switches between the two conduction modes drastically, the response time can be controlled within 30 μs. The undershoot voltage is controlled within 25 mV under a large current hopping range.
Mathematical analysis of organic-pass transistor using pseudo-p-OTFTs
Authors: Pal Shagun , Kumar Brijesh 
Published: June 2020

Abstract
Steady state behavior analysis of organic thin film transistor (OTFTs) has been thoroughly researched in the past few decades. Yet, this static logic analysis has drawbacks of high power dissipation and high power consumption, and a large number of prerequisites in the number of transistors for the digital logic circuit application. Hence, to overcome these basic fundamental drawbacks of static logic, the dynamic logic study of organic thin film transistor has been analyzed in this paper. The fundamental basic of dynamic logic is a pass transistor for which logic high and logic low model is designed at an operating voltage of 5 V and frequency of 5 kHz. Additionally, the novel approach of analytical model for organic pass transistor (OPT) circuit is included and verified using MATLAB. The transient individualities of organic pass transistor OPT are examined through Atlas 2-D numerical device simulator. The reduction in the power dissipation along with additional voltage scaling and reduction in the clock frequency such as pipelining may further enable the applications into more complex VLSI ICs.
Numerical study of mono-crystalline silicon solar cells with passivated emitter and rear contact configuration for the efficiency beyond 24% based on mass production technology
Authors: Wang Peng , Li Gaofei , Wang Miao , Li Hong , Zheng Jing , Yang Liyou , Chen Yigang , Li Dongdong , Lu Linfeng 
Published: June 2020

Abstract
Mono-crystalline silicon solar cells with a passivated emitter rear contact (PERC) configuration have attracted extensive attention from both industry and scientific communities. A record efficiency of 24.06% on p-type silicon wafer and mass production efficiency around 22% have been demonstrated, mainly due to its superior rear side passivation. In this work, the PERC solar cells with a p-type silicon wafer were numerically studied in terms of the surface passivation, quality of silicon wafer and metal electrodes. A rational way to achieve a 24% mass-production efficiency was proposed. Free energy loss analyses were adopted to address the loss sources with respect to the limit efficiency of 29%, which provides a guideline for the design and manufacture of a high-efficiency PERC solar cell.
CO2 emissions from forest degradation in Brazilian Amazon
Authors: Assis Talita Oliveira , de Aguiar Ana Paula Dutra , von Randow Celso , Melo de Paula Gomes Diego , Kury Juliana Nunes , Ometto Jean Pierre H B , Nobre Carlos A 
Published: June 2020

Abstract
Forest degradation is widespread around the world, due to multiple factors such as unsustainable logging, agriculture, invasive species, fire, fuelwood gathering, and livestock grazing. In the Brazilian Amazon forest degradation from August 2006 to July 2016 reached 1,1 869 800 ha. The processes of forest degradation are still poorly understood, being a missing component in anthropogenic CO2 emission estimates in tropical forests. In this work, we analyzed temporal trajectories of forest degradation from August 2006 to July 2016 in the Brazilian Amazon and assessed their impact on the regional carbon balance. We combined the degradation process with deforestation-related processes (clear-cut deforestation and secondary vegetation dynamics), using the spatially-explicit INPE-EM carbon emission model. The trajectory analysis showed that 13% of the degraded area ended up being cleared and converted in the period and 61% of the total degraded area experienced only one event of degradation throughout the whole period. Net emissions added up to 5.4 GtCO2, considering the emissions from forest degradation and deforestation, absorption from degraded forest recovery, and secondary vegetation dynamics. The results show an increase in the contribution of forest degradation to net emissions towards the end of the period, related to the decrease in clear-cut deforestation rates, decoupled from the forest degradation rates. The analysis also indicates that the regeneration of degraded forests absorbed 1.8 GtCO2 from August 2006 and July 2016—a component typically overlooked in the regional carbon balance.
Get Parkinson’s medications on time: the Leeds QI project
Authors: Corrado Joanna , Jackson Oliver , Baxandall David , Robson Jeremy , Duggan-Carter Philippa , Throssell Jane , Westgarth Tracy , Chhokar Gurjit , Alty Jane , Cracknell Alison 
Published: June 2020

Abstract
Parkinson’s disease (PD) is a common neurodegenerative disease. Delayed administration of PD medications is associated with increased risk of life-threatening complications including choking, aspiration pneumonia and neuroleptic malignant syndrome.
In 2016, the spouse of a patient with PD wrote to Leeds Teaching Hospitals Trust (LTHT) to highlight that multiple medication delays and omissions had occurred during his recent admission. In response, LTHT formed a PD quality improvement (QI) Collaborative of multidisciplinary members committed to ensuring timely PD medication administration.
The faculty used Institute for Healthcare Improvement Model for Improvement QI methodology. Interventions were tested on pilot wards and the most successful were scaled up and spread across all 90 adult inpatient wards as an ‘intervention bundle’.
Between January 2016 and June 2020 mean delays in the time from admission to first dose of medication dropped from over 7 to under 1 h. The mean percentage of omitted PD medications reduced from 15.1 to 0.6%.
Project success was multifactorial but due to: Simplicity of interventions.Multiprofessional ownership by frontline teams to make changes and take prompt action.The spouse of the patient taking a leading role in the Collaborative, bringing her unique personal insight and experience, which facilitated behavioural change.
Towards precision medicine: Therapeutic drug monitoring–guided dosing of vancomycin and β-lactam antibiotics to maximize effectiveness and minimize toxicity
Authors: Cusumano Jaclyn A , Klinker Kenneth P , Huttner Angela , Luther Megan K , Roberts Jason A , LaPlante Kerry L 
Published: June 2020

AbstractPurposeThe goal of this review is to explore the role of antimicrobial therapeutic drug monitoring (TDM), especially in critically ill, obese, and older adults, with a specific focus on β-lactams and vancomycin.SummaryThe continued rise of antimicrobial resistance prompts the need to optimize antimicrobial dosing. The aim of TDM is to individualize antimicrobial dosing to achieve antibiotic exposures associated with improved patient outcomes. Initially, TDM was developed to minimize adverse effects during use of narrow therapeutic index agents. Today, patient and organism complexity are expanding the need for precision dosing through TDM services. Alterations of pharmacokinetics and pharmacodynamics (PK/PD) in the critically ill, obese, and older adult populations, in conjunction with declining organism susceptibility, complicate attainment of therapeutic targets. Over the last decade, antimicrobial TDM has expanded with the emergence of literature supporting β-lactam TDM and a shift from monitoring vancomycin trough concentrations to monitoring of the ratio of area under the concentration (AUC) curve to minimum inhibitory concentration (MIC). PK/PD experts should be at the forefront of implementing precision dosing practices.ConclusionPrecision dosing through TDM is expanding and is especially important in populations with altered PK/PD, including critically ill, obese, and older adults. Due to wide PK/PD variability in these populations, TDM is vital to maximize antimicrobial effectiveness and decrease adverse event rates. However, there is still a need for studies connecting TDM to patient outcomes. Providing patient-specific care through β-lactam TDM and transitioning to vancomycin AUC/MIC monitoring may be challenging, but with experts at the forefront of this initiative, PK-based optimization of antimicrobial therapy can be achieved.
Clinical pharmacy programmatic perspectives on use of direct-acting antivirals for acquired hepatitis C infection in solid organ transplant recipients
Authors: Crona Lana , Berry Holly , Byrns Jennifer , Campbell Udobi 
Published: June 2020

Abstract

Purpose
An institutional workflow developed by clinical pharmacists for initiation of directing-acting antiviral (DAA) therapy for patients who receive solid organ transplants from hepatitis C (HCV)–positive donors is described; programmatic challenges in providing pharmaceutical care to these patients are reviewed.

Summary
In recent years the introduction of new oral DAAs, coupled with faster screening of donor organs for HCV infection through use of a nucleic acid test (NAT), has facilitated transplants of organs from HCV-seropositive donors to HCV-seronegative recipients. The solid organ transplant program of a North Carolina health system began performing such transplants in December 2017. In the pharmacist-developed workflow, patients are initiated on DAA therapy in the outpatient clinic setting, and clinic pharmacists are consulted regarding drug selection. Prescriptions for DAA therapy are sent to an on-site specialty pharmacy, where pharmacists and pharmacy technicians work to obtain prior authorization and, if necessary, payment assistance through manufacturer-sponsored programs. The medical team is notified at the time of patient approval to begin treatment. Pharmacists provide counseling at the time of DAA therapy initiation and follow up with patients every 2 weeks to confirm adherence. As of June 2019, about 100 transplants of HCV NAT–positive organs had been performed (approximately 50% were kidney transplants; 15%, lung transplants; 20%, heart transplants; and 15%, liver transplants). Many challenges are encountered in the process of providing pharmaceutical care to this patient population, including challenges in patient selection and counseling, overcoming financial barriers and insurance restrictions, and coordinating with an internal specialty pharmacy to ensure timely delivery of medication to patients.

Conclusion
Within a solid organ transplantation program, clinical pharmacists and other pharmacy personnel can play vital roles in ensuring safe and effective DAA therapy for recipients of transplanted HCV NAT–positive organs.
Impact of PhORCAS references on overall application score for postgraduate year 1 pharmacy residency candidates
Authors: Atyia Sara A , Paloucek Frank P , Butts Allison R , Oyler Douglas R , Martin Craig A , Schadler Aric D , Cook Aaron M 
Published: June 2020

Abstract

Purpose
The disparity between the number of applicants for postgraduate year 1 (PGY1) pharmacy residency positions and the number of available residency positions increases the need to optimize how applicants are evaluated. The purpose of the study described here was to evaluate the correlation of ratings of residency candidate characteristics by academic and professional references listed on residency applications with overall application score, applicant ranking, and the likelihood of candidates receiving an invitation to interview.

Methods
A multicenter, retrospective study was conducted to evaluate the correlation of reference writers’ ratings of 13 candidate characteristics and their overall recommendations with program-determined outcomes (eg, final application score, applicant ranking, and invitation to interview) through analysis of PGY1 applications submitted through the Pharmacy Online Residency Centralized Application System (PhORCAS) from 2015 through 2018. Keywords and themes within the open-ended section of letters of reference were also analyzed for correlation with overall application score.

Results
A total of 5,923 references listed on 1,867 applications to 4 PGY1 pharmacy residency programs processed by PhORCAS were included in the analysis. For the majority of applicant characteristic ratings (ie, 74% of 56,872 ratings overall), reference writers rated candidates as exceeding expectations, and applicants were “highly recommended” by these evaluators in 91% of cases. References’ average characteristic ratings and overall recommendations were poorly correlated with final application score (R2 = 0.12 [P &lt; 0.0001] and R2 = 0.08 [P &lt; 0.0001], respectively), final ranking (R2 = 0.02 [P &lt; 0.0001] and R2 = 0.03 [P &lt; 0.0001], respectively), and invitation to interview (R2 = 0.07 [P &lt; 0.0001] and R2 = 0.04 [P &lt; 0.0001], respectively). For the themes evaluated, references’ use of teaching words best correlated with normalized final application score, although the correlation was poor (R2 = 0.007, P = 0.0001).

Conclusion
Reference writers’ ratings of PGY1 residency candidate characteristics in PhORCAS are poorly correlated with application score, applicant ranking, and invitation to interview. The results of this study suggest that the existing PhORCAS standardized form for submitting references is of limited utility in its current state.
XIII—Dutch Book and Accuracy Theorems
Authors: Mahtani Anna 
Published: June 2020

Abstract
Dutch book and accuracy arguments are used to justify certain rationality constraints on credence functions. Underlying these Dutch book and accuracy arguments are associated theorems, and I show that the interpretation of these theorems can vary along a range of dimensions. Given that the theorems can be interpreted in a variety of different ways, what is the status of the associated arguments? I consider three possibilities: we could aggregate the results of the differently interpreted theorems in some way, and motivate rationality constraints based on this aggregation; we could be permissive, and accept the conclusions of the Dutch book and accuracy arguments under all interpretations of the associated theorems; or we could select one uniquely correct interpretation of the Dutch book or accuracy theorem, and use that to justify certain rationality constraints. I show that each possibility faces problems, and conclude that Dutch book and accuracy theorems cannot be used to justify any principle of rationality.
BioModels Parameters: a treasure trove of parameter values from published systems biology models
Authors: Glont Mihai , Arankalle Chinmay , Tiwari Krishna , Nguyen Tung V N , Hermjakob Henning , Malik-Sheriff Rahuman S 
Published: June 2020

Abstract

Motivation
One of the major bottlenecks in building systems biology models is identification and estimation of model parameters for model calibration. Searching for model parameters from published literature and models is an essential, yet laborious task.

Results
We have developed a new service, BioModels Parameters, to facilitate search and retrieval of parameter values from the Systems Biology Markup Language models stored in BioModels. Modellers can now directly search for a model entity (e.g. a protein or drug) to retrieve the rate equations describing it; the associated parameter values (e.g. degradation rate, production rate, Kcat, Michaelis–Menten constant, etc.) and the initial concentrations. Currently, BioModels Parameters contains entries from over 84,000 reactions and 60 different taxa with cross-references. The retrieved rate equations and parameters can be used for scanning parameter ranges, model fitting and model extension. Thus, BioModels Parameters will be a valuable service for systems biology modellers.

Availability and implementation
The data are accessible via web interface and API. BioModels Parameters is free to use and is publicly available at https://www.ebi.ac.uk/biomodels/parameterSearch.

Supplementary information
Supplementary data are available at Bioinformatics online.
The Jaw Epidemic: Recognition, Origins, Cures, and Prevention
Authors: Kahn Sandra , Ehrlich Paul , Feldman Marcus , Sapolsky Robert , Wong Simon 
Published: June 2020

AbstractContemporary humans are living very different lives from those of their ancestors, and some of the changes have had serious consequences for health. Multiple chronic “diseases of civilization,” such as cardiovascular problems, cancers, ADHD, and dementias are prevalent, increasing morbidity rates. Stress, including the disruption of traditional sleep patterns by modern lifestyles, plays a prominent role in the etiology of these diseases, including obstructive sleep apnea. Surprisingly, jaw shrinkage since the agricultural revolution, leading to an epidemic of crooked teeth, a lack of adequate space for the last molars (wisdom teeth), and constricted airways, is a major cause of sleep-related stress. Despite claims that the cause of this jaw epidemic is somehow genetic, the speed with which human jaws have changed, especially in the last few centuries, is much too fast to be evolutionary. Correlation in time and space strongly suggests the symptoms are phenotypic responses to a vast natural experiment—rapid and dramatic modifications of human physical and cultural environments. The agricultural and industrial revolutions have produced smaller jaws and less-toned muscles of the face and oropharynx, which contribute to the serious health problems mentioned above. The mechanism of change, research and clinical trials suggest, lies in orofacial posture, the way people now hold their jaws when not voluntarily moving them in speaking or eating and especially when sleeping. The critical resting oral posture has been disrupted in societies no longer hunting and gathering. Virtually all aspects of how modern people function and rest are radically different from those of our ancestors. We also briefly discuss treatment of jaw symptoms and possible clinical cures for individuals, as well as changes in society that might lead to better care and, ultimately, prevention.
Pronounced differences in visitation by potential pollinators to co-occurring species of Fabaceae in the Southwest Australian biodiversity hotspot
Authors: Scaccabarozzi Daniela , Dixon Kingsley W , Tomlinson Sean , Milne Lynne , Bohman Björn , Phillips Ryan D , Cozzolino Salvatore 
Published: June 2020

AbstractDespite their diversity and the potential for specialized pollination systems, Australian Fabaceae have received little attention in pollination studies. In the Southwest Australian Floristic Region (SWAFR), a recognized biodiversity hotspot, co-occurring and abundant species of Faboideae exhibit a range of floral colours and forms, suggestive of adaptation to different groups of pollinators. For four communities of Fabaceae in the SWAFR we investigated whether co-occurring species overlap in pollinator genera, whether these pollinators show differences in behaviour on the pea flower and whether variations in stamen length and nectar composition among species are associated with different pollinator types. Species of Fabaceae were visited by one to four genera of native bees, suggesting varying levels of ecological specialisation. In Fabaceae with more specialized interactions, co-occurring species showed marked differences in the bee genera attracted. Unexpectedly, some Fabaceae frequently attracted beetles, which may play an important role in their pollination. There was no evidence for an association between stamen length or nectar composition and the type of pollinator. The introduced honeybee, visited all studied species of Fabaceae, suggesting that they may act both as a pollinator and a potential competitor with native pollinators.