bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral sodium phenylbutyrate for hyperammonemia associated with congenital portosystemic shunt: a case report
Authors: Sato Takeshi , Ishii Tomohiro , Kato Mototoshi , Oyanagi Takayuki , Nakatsuka Seishi , Kuroda Tatsuo , Hasegawa Tomonobu 
Published: December 2020

Abstract

Objectives
The efficacy of sodium phenylbutyrate (SPB) for hyperammonemia associated with congenital portosystemic shunt (CPSS) remains unknown. We show the effectiveness of oral SPB.

Case presentation
Our patient had CPSS with severe hypoplasia of extrahepatic portal veins. At 9 months of age, to assess the efficacy of oral SPB, we evaluated the 24 h fluctuations of venous ammonia levels. In the first two days without SPB, ammonia levels were above 80 μmol/L for half a day. On the third and fourth days, administration of oral SPB three times a day decreased ammonia to acceptable levels, except at midnight. On the fifth day, another oral SPB administration at 8 pm decreased ammonia at midnight. Low levels of branched-chain amino acids, as well as coagulation disturbances, were observed without apparent symptoms. At 12 months of age, he showed normal psychomotor development.

Conclusions
Oral SPB may be effective for hyperammonemia associated with CPSS.
Representing Uncertainty in Property Valuation Through a Bayesian Deep Learning Approach
Authors: Lee Changro , Park Keith Key-Ho 
Published: December 2020

Abstract
Although deep learning-based valuation models are spreading throughout the real estate industry following the artificial intelligence boom, property owners and investors continue to doubt the accuracy of the results. In this study, we specify a neural network for predicting house prices. We suggest a standard feed-forward network with two hidden layers, and show that it is sufficiently reasonable to apply its prediction to real-world projects such as property valuation. In addition, we propose a Bayesian neural network for describing uncertainty in house price predictions while providing a means to quantify uncertainty for each prediction. We choose Gangnam-gu, Seoul for the analysis, and predict house prices in the area using both networks. Although the Bayesian neural network did not perform better than the conventional network, it could provide a tool to measure the uncertainty inherent in predicted prices. The findings of this study show that a Bayesian approach can model uncertainty in property valuation, thereby promoting the adoption of deep learning tools in the real estate industry.
The Incremental Launching Construction Technology of Pontoon Pivot Conversion of Large-span Steel Arch Bridge
Authors: Wang Jin 
Published: December 2020

Abstract
With the progress of building materials and building technology, the span of bridges is becoming larger and larger. This paper briefly introduces the incremental launching construction technology of a bridge and the incremental launching construction technology of pontoon fulcrum conversion, makes an instance analysis on a large-span steel arch bridge that adopted the incremental launching technology of pontoon fulcrum conversion in Shaoyang, Hunan, China, and makes a simulation calculation on the construction process using Midas civil software. The construction process was monitored using stress sensors and total station. The results showed that the simulation results of the stress and deformation changes of the steel arch bridge in the construction process were close to the actual monitoring data, and the variation trend was basically the same. The finite element model effectively simulated the stress and deformation changes of the steel arch bridge in incremental launching. With the progress of construction conditions, the maximum stress and deformation degree of the arch rib increased first and then decreased, the maximum stress and deformation degree of the main longitudinal beam showed an increase tendency, the maximum stress of the front guide beam increased first and then decreased, and the deformation degree gradually decreased.
Teleophthalmology and its impact- An eye disease pattern analysis in central India’s hot spot during COVID-19 pandemic
Authors: Agarwal Mahesh , Agrawal Teena 
Published: December 2020

COVID-19 pandemic has put all of us in astonishment and concern about its management and survival of human being since there is a great risk of human to human transmission. Teleophthalmology can play a great role to overcome this situation. Earlier teleophthalmology was mainly limited to diagnoistic reachout camps for diabetic eye disease mainly without treatment benefit to the patient. Now with advancement in media technology and availability of good quality smart phones, it is possible to extend scope of teleophthalmlogy for the treatment of superficial ailments of an eye. Our aim of the study was to analyse the eye disease pattern and impact of teleophthalmology on its management in one of the hot centre of India, i.e. Indore, during pandemic period.This study is a retrospective, interventional data analysis of patients seen in one month of Lockdown in India, from 26 March to 25 April 2020. All the patients were given teleconsultation with the help of voice calls and still pictures; video call was used wherever it was feasible. In our study, we have divided patients in two groups, first is Tele OSD (Tele Ocular Surface Disorders) where diagnosis on 2D image or video was possible and second group were OED (Other Eye Disease) where in-person consultation was required before making diagnosis or offering treatment.We have done analysis of total 119 patients records who made a call for eye problems between 26 March2020 to 25 April 2020. Out of 119 patients, 107 patients (89.91%) were in Tele OSD and 12 patients (10.08%) were in OED group. Telemedicine was prescribed in 103 patients (103/107, of tele OSD group- 96.26%), of which 102 patients (95.32%) showed marked improvement or are cured on follow-up. Among the Tele OSD group who received the treatment (103 patients), 79 patients (76.99%) were of conjunctivitis, varying from infectious to allergic origin who responded very well to treatment offered.COVID-19 pandemic has changed the understanding of medical science. Previously telemedicine (more precisely teleophthalmology) used to be a tool for outreach patient diagnosis mainly in rural or suburb area, but now with the advancement of digital media and easy availability of smart phones, it can also be used in the management of common eye diseases, even in urban population.
Central corneal thickness and intraocular pressure in primary open angle glaucoma suspects in a south Indian population. Is it time for “corneal anthropology”?
Authors: Sharma Ashok , Sharma Rajan , K S Nagaraja , Sujatha Rani , C N Prashant 
Published: December 2020

To study correlation between central corneal thickness (CCT) and intraocular pressure (IOP) in the primary open angle glaucoma (POAG) suspects and to assess the importance of the local population reference CCT in pachymetry adjusted IOP.Prospective, cross sectional study.A total of 100 patients aged 40-70 years of age diagnosed as POAG suspects were included. CCT measurements using ultrasound pachymetry and IOP measurement with Goldmann applanation tonometer (GAT) was done. IOP was corrected to the local south-Indian baseline CCT and also to the International CCT and comparison was done.The study included 100 patients (58 male and 42 female) with mean age of 51.7 ± 6.1 years. The mean CCT was 518.91 ± 24.26 μm, 522.19 ± 21.56 μm among females, males respectively. The mean uncorrected IOP (GAT) was 19.50 mmHg, 20.14 mmHg (right, left sides). Significant, moderate positive correlation between CCT and IOP was observed. The two groups i.e mean IOP corrected for South-Indian CCT (Mean_CX_IOP) versus IOP corrected for CCT international (Mean_CX_INT_IOP) showed significant difference. The mean IOP in Indian CCT corrected group was 19.76 ± 2.81 mmHg and in international CCT group was 21.51 ± 2.83 mmHg. Levene's test indicated significant difference in mean IOP of 2 groups (p=0.000).CCT is an important parameter in glaucoma management and known to vary in different ethnic groups. Local ethnicity specific CCT should be used in IOP correction with the help of anthropologists.
AGRONOMIC TRAITS EVALUATION IN IRRIGATED SORGHUM IN THE BRAZILIAN SEMI-ARID
Authors: NETO AMADEU REGITANO , SANTOS RAFAEL DANTAS DOS 
Published: December 2020

Green and dry matter production, along with grain yield and otheragronomic traits, were assessed in 44 sorghum genotypes. Two sets of genotypes were formed based on known plant height, aiming to evaluate green and dry matter production and grain yield, as well as to separate forage and grain sorghum genotypes. The evaluations were performed based on experiments with three replications, being one irrigated (drip system) in Petrolina, State of Pernambuco, and the other rainfed, in Nossa Senhora da Glória, state of Sergipe, Brazil. Sowing dates were July 30, 2016, in Nossa Senhora da Glória; July 13, 2017, and October 24, 2018, in Petrolina; with 117 and 128 days from sowing to harvest, respectively. Expressive forage production was observed in genotypes EP-17 and SF-11, which exceeded 120 t ha-1. BRS 506 produced 108 t ha-1, while 13F03(1141572), P-294, P-288, 2502 x 467, BRS Ponta Negra, and SF-15 presented green matter production ranging from 94 to 98.5 t ha-1. Dry matter production was highly correlated with green matter production, and SF-11 had the best performance of 45.5 t ha-1. The observed plant height was more expressive for forage sorghum genotypes, being this trait highly correlated with the green and dry matter. The best grain yield performance reached 13.4 and 10.3 t ha-1, values observed for 9910032 and BRS Ponta Negra, respectively. The results demonstrate the full adaptability of sorghum to the semi-arid environment and the feasibility to produce roughage and grains under irrigation in the Brazilian semi-arid region.
TOP-DRESSING NITROGEN DOSES IN MAIZE SOWN IN SINGLE AND DOUBLE ROWS AND CULTIVATED IN WINTER
Authors: COELHO ANDERSON PRATES , SOUSA JÚNIOR INÁCIO DE , LEAL FÁBIO TIRABOSCHI , LEMOS LEANDRO BORGES 
Published: December 2020

Due to the intensification of production in irrigated areas, maize hasbeen sown in winter, enabling three seasons in one agricultural year. The objective of this study was to evaluate the agronomic performance of maize under irrigation and cultivated in winter under different plant arrangements (single and doublerow) under top-dressing nitrogen doses. The experimental design used was in randomized blocks in a split-plot scheme, with four replicates. Plots were formed by sowing systems single and double rows and subplots were formed by four top-dressing N doses: 0 kg ha-1 of N; 80 kg ha-1 of N with single application in phenological stage V3; 160 kg ha-1 of N with application of 80 kg ha-1 in V3 and V6, and 240 kg ha-1 of N with application of 80 kg ha-1 in stages V3, V6 and V8. The single-row sowing system led to higher grain yield compared to maize grown in the double-row system. Maize grain yield showed progressive linear increments with increasing top-dressing N doses, reaching 11,089 kg ha-1 of grains with the maximum studied dose of 240 kg ha-1 of N. Sowing systems in single and double rows do not differ with respect to the use of top-dressing N.
Delta-range coupling between prefrontal cortex and hippocampus supported by respiratory rhythmic input from the olfactory bulb in freely behaving rats
Authors: Mofleh Rola , Kocsis Bernat 
Published: December 2020

Abstract
An explosion of recent findings firmly demonstrated that brain activity and cognitive function in rodents and humans are modulated synchronously with nasal respiration. Rhythmic respiratory (RR) coupling of wide-spread forebrain activity was confirmed using advanced techniques, including current source density analysis, single unit firing, and phase modulation of local gamma activity, creating solid premise for investigating how higher networks use this mechanism in their communication. Here we show essential differences in the way prefrontal cortex (PFC) and hippocampus (HC) process the RR signal from the olfactory bulb (OB) allowing dynamic PFC-HC coupling utilizing this input. We used inter-regional coherences and their correlations in rats, breathing at low rate (~ 2 Hz) at rest, outside of the short sniffing bouts. We found strong and stable OB-PFC coherence, contrasting OB-HC coherence which was low but highly variable. PFC-HC coupling, however, primarily correlated with the latter, indicating that HC access to the PFC output is dynamically regulated by the responsiveness of HC to the common rhythmic drive. This pattern was present in both theta and non-theta states of waking, whereas PFC-HC communication appeared protected from RR synchronization in sleep states. The findings help to understand the mechanism of rhythmic modulation of non-olfactory cognitive processes by the on-going regular respiration, reported in rodents as well as humans. These mechanisms may also be important to understand how OB-pathology may lead to neurological consequences, similar to known olfactory disturbances in COVID-19.
Systematic Description of the Expression and Prognostic Value of M6A Regulators in Human Ovarian Cancer
Authors: Chen Yuwei , Sun Yang , Chen Xinbei , Li Siming , Xia Hongmei 
Published: December 2020

Abstract
Background: N6-methyladenine (m6A) methylation, known as a kind of RNA methylation regulator, has become a hotspot for research in the life sciences in recent years. The existing studies revealed that m6A regulators helped to regulate the progression of several malignant tumors. However, the expression mode and prognostic value of m6A regulators in ovarian cancer have not been fully elucidated.Methods: ONCOMINE, GEPIA, Human protein atlas, Kaplan-meier, UALCAN, cBioPortal, GeneMANIA, DAVID, Sring, and Metascape were utilized in this study.Results: In this study, through a comprehensive use of multiple database systems, m6A regulators-induced mRNA and protein expression levels and their prognostic value in the epithelial ovarian cancer of various histological types were analyzed. Moreover, the interaction, epigenetic changes and functional enrichment of m6A regulators in ovarian cancer were also discussed. By analyzing the transcription levels and survival curves of m6A regulators in serous and endometrioid ovarian cancer s, it was found that FTO, YTHDF1, YTHDF2 and IGF2BP1 could be used as the therapeutic target for serous ovarian cancer. YTHDC2 and IGF2BP2 could serve as endometrioid ovarian cancer’s therapeutic target and potential prognostic biomarker, respectively.Conclusions: Our results may provide novel insights for the selection of therapeutic targets and prognostic biomarkers for serous and endometrioid ovarian cancers.
Effect of Al2O3/SiO2 on the structure and properties of blast furnace slag glass-ceramics
Authors: Li Zuhao , He Feng , Zhang Wentao , Xie Junlin 
Published: December 2020

Abstract
Different Al2O3/SiO2 glass-ceramics were prepared from blast furnace slag by traditional sintering method. The structure and properties of glasses or glass-ceramics were investigated by DSC, XRD, SEM, FTIR, 27Al MAS NMR. The DSC results showed that with the increase of Al2O3/SiO2, the glass transition temperature (Tg) first increased and then decreased, reached the minimum when Al2O3/SiO2 was 0.34. The volume density, bending strength and microhardness of glass-ceramics also showed the same variation rule. The FTIR and 27Al MAS NMR spectra results revealed this phenomenon. When Al2O3/SiO2 was 0.19, a large amount of Si4+ was added to the glass network to make the structure dense. With Al2O3/SiO2 increased from 0.24 to 0.34, the amount of [AlO6] in the glass increased while [AlO4] decreased, and the degree of network polymerization of the glass decreased; as Al2O3/SiO2 further increased from 0.34 to 0.39, [AlO4] increased and [AlO6] decreased in the glass, and the degree of network polymerization of the glass increased. The XRD results showed that the crystal phase of the glass-ceramics was composed of gehlenite, diopside and hyalophane. Moreover, with the increase of Al2O3/SiO2, the gehlenite content in the glass-ceramics increased, while the content of diopside and hyalophane decreased.
The Historical Views on the Disease Name, Etiology and Pathogenesis for Gastroesophageal Reflux Disease in Traditional Chinese Medicine with Combined Knowledge Graph and Qualitative analysis
Authors: HOU Kun Zheng , Pu Si-qi , LIU Feng-bin , Zhang Mei , Tao Shuang-you , Chen Bin , LIU Zong-xin , LI Shuang-yan , Xin Yi-jun 
Published: December 2020

Abstract
Background

To clarify the historical views on disease name, etiology and pathogenesis for Gastroesophageal reflux disease (GERD) in ancient Traditional Chinese Medicine (TCM).
Methods

A comprehensive literature search was performed in < Zhong Hua Yi Dian > database with keywords ‘Acid regurgitation’, ‘Epigastric upset’ and ‘Bilious vomiting’. All the information about disease names, etiology and pathogenesis were included and extracted by two independent reviewers. The Citespace software was used for data analysis. After data importing and purging, the analysis was performed in two steps with 1000 years interval. This study mainly used descriptive statistics, co-occurrence analysis, and cluster analysis, accompanied with qualitative analysis.
Results

A total of 187 disease name, 286 etiology and 429 pathogenesis records related to GERD were final identified. The authors and bibliographies co-occurrence analysis showed there were 13 main nodes and 6 lines before 1000 A.D., 151 nodes and 65 lines after 1000 A.D.. As for disease name, ‘Ou Ku’ and ‘Ou Dan’, the earliest names related to GERD in TCM appeared in the Han and Jin dynasties. In disease etiology analysis, 8 nodes appeared during 1-1000 A.D. and increased rapidly until 1900 A.D.; the cluster analysis identified 9 research hotspots which contains Internal injury diet, Pathogenic factor of gallbladder, Internal injury due to emotional disorder, Food retention, Heat stagnation of body fluid, Incoordination between the spleen and stomach, Damp-heat syndrome of stomach, Phlegm-fire, Cold evil invading the stomach. As for disease pathogenesis, the earliest explanation ‘the evil in gallbladder and ascendant rising of stomach qi’ was appeared in the 3rd century; the cluster analysis identified 8 research hotspots which contains Spleen qi deficiency and adverse rising of phlegm and fluid retention, Pathogenic factor invading upper-jiao, Heat stagnation of body fluid at lung and stomach, Insufficiency-cold of middle qi, Phlegm moving due to fire, Phlegm and fluid retention in upper-jiao and cold food retention of stomach, Sufficient wood and insufficient soil, Food retention of middle-jiao.
Conclusions

There are many treatises focused on GERD related symptoms and signs in TCM. This study clarified its name, etiology and pathogenesis, which provides a good reference for further theoretical and clinical research.
The Value of Three-Dimensional Printing Spine Model in Severe Spine Deformity Correction Surgery
Authors: Pan Aixing , Ding Hongtao , Hai Yong , Hai Junrui Jonathan , Yin Peng , Han Bo 
Published: December 2020

Abstract
Objective. We aimed to evaluate the value of 3-dimensional printing (3DP) spine model in the surgical treatment of severe spinal deformity since the prosperous development of 3DP technology.Materials and Methods. Severe scoliosis or hyper-kyphosis patients underwent posterior fixation and fusion surgery using the 3DP spine models were reviewed (3DP group). Spinal deformity surgeries operated by free-hand screw implantation during the same period were selected as the control group after propensity score matching (PSM). The correction rate, pedicle screw accuracy, and complications were analyzed. Class A and B screws were defined as accurate according to Gertzbein and Robbins criteria.Results. 35 patients were enrolled in the 3DP group and 35 matched cases were included in the control group. The perioperative baseline data and deformity correction rate were similar between both groups (P>0.05). However, the operation time and blood loss were significantly less in the 3DP group (296.14±66.18 min vs. 329.43±67.16 min, 711.43±552.28 mL vs. 1322.29±828.23 mL, P<0.05). More three-column osteotomies (Grade 3-6) were performed in the 3DP group (30/35, 85.7% vs. 21/35, 60.0%. P=0.016). The screw placement accuracy was significantly higher in the 3DP group (422/582, 72.51% vs. 397/575, 69.04%. P=0.024). The screw misplacement related complication rate was significantly higher in the free-hand group (6/35 vs. 1/35, P=0.046).Conclusion. The study provided solid evidence that 3DP spine models can enhance surgeons' confidence in performing higher grade osteotomies and improve the safety and efficiency in severe spine deformity correction surgery. 3D printing technology has a good prospect in spinal deformity surgery.
Identifying the Purposes of Biological Materials in Everyday Designs
Authors: Ahmad Sayuti Nurul 'Ayn , Sommer Bjorn , Ahmed-Kristensen Saeema 
Published: December 2020

The exploration of new materials has provided new insights into the progressive use of living biological materials in everyday designs. Living biological materials are expected to have the potential to overcome the depletion of non-renewable resources. Through bio-design and biophilic design in the urban environment, designers apply living systems as appropriate solutions to everyday designs. This paper aims to classify the biological materials and the sense of ownership towards biological materials embedded in products in terms of a) Function, b) Aesthetic and Semantic, and c) Emotion and Experience. A survey was conducted from 173 respondents through an online questionnaire.
Keywords: biological materials; biophilic design; product designs; purposes and ownership
eISSN: 2398-4287© 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v5i15.2479
Direito Autoral e Contrato de Representação
Authors: E Silva Oliveira 
Published: December 2020

Várias teses, de alta relevância, aí são discutidas e decididas, demonstrando o relator des. João Coelho Branco profundeza e agudeza no conhecimento do direito do autor em face do empresário que lhe contrata a representação da peça teatral. Daí o seu voto luminoso que servirá de roteiro na jurisprudência que se vai formando, a respeito, no Brasil.
Em primeiro lugar, discute o Acórdão de 3 de novembro de 1954 se a representação da obra teatral, nos têrmos das leis em vigor, está ou não, subordinada à existência de contrato entre as partes interessadas e ende se expressem os direitos dominicais do autor. Ainda se, havendo autorização preliminar, precisa esta aperfeiçoar-se, concluir-se em convenção definitiva para que haja um contrato orgânico.