bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subtropical specialists dominate a coral range expansion front
Authors: Chong Fiona , Soong Giun Yee , Hakim Agus Alim , Burke Camille , De Palmas Stéphane , Gösser Fabian , Hsiao Wanchien Victoria , Kise Hiroki , Nishijima Miyuki , Iguchi Akira , Sommer Brigitte , Joyce Domino , Beger Maria , Reimer James Davis 
Published: December 2024

AbstractPotential range expansion of scleractinian corals in high-latitude reefs is critically dependent on the coral host-symbiont relationship that determines coral growth and survival. Although increases in coral cover have been observed at higher latitudes, the identities of habitat-building reef corals and their symbionts are underreported. Here, we examine how scleractinian host and symbiont Symbiodiniaceae diversity changes along a tropical–temperate environmental gradient. We use Pocillopora spp. and associated symbiont communities as a model to understand whether they are expanding their range poleward and the role of symbionts in this process. Along the Kuroshio Current, which carries warm equatorial waters northward along the Pacific coast of Japan, we collected coral tissues from 23 (sub)tropical-to-temperate reefs, from southern Iriomote in the Ryukyu Islands (24°N) to northernmost Kushimoto on mainland Japan (33°N). We examined host identities through direct sequencing of the mitochondrial open reading frame (mtORF) and symbiont identities with next-generation sequencing of the internal transcribed spacer 2 (ITS2) region of the ribosomal DNA. Our results show a dramatic reduction of Pocillopora haplotypes and a marked change in dominant symbiont types northward (poleward) from Cape Sata (30°N), Kagoshima. ‘Tropical’ Pocillopora haplotypes were absent from mainland Japan sites. We also demonstrate high host specificity between the subtropical Pocillopora haplotype and Cladocopium symbiont types. Our findings question how common ‘coral tropicalisation’ is, and the location of the coral range expansion front. The specificity of hosts and symbionts in high-latitude corals suggests that high-latitude reefs are unlikely to support the persistence of tropical zooxanthellate corals.
Fabrication of a ferrite microcrystal using optical vortex laser induced forward transfer
Authors: Kaneko Akihiro , Iwata Muneaki , Yuyama Ken-ichi , Omatsu Takashige 
Published: December 2024

Abstract
Optical vortex induced forward transfer (OV-LIFT) allows the crystallization of magnetic nanoparticles enabling the fabrication of a 2-dimensional array of monocrystalline structures with a high spatial resolution. We herein investigate the optimum experimental conditions, such as the viscosity range of the donor and the energy range of the optical vortex pulse required for the crystallization of magnetic nanoparticles through a cavitation processes, including the flight dynamics of donor.
Clinical and radiologic criteria to predict endoscopic third ventriculostomy success in non-communicating pediatric hydrocephalus
Authors: Tatoshvili Davit , Schaumann Andreas , Tietze Anna , Pennacchietti Valentina , Cohrs Gesa , Schulz Matthias , Thomale Ulrich-W. 
Published: December 2024

Abstract
Objective
Endoscopic third ventriculocisternostomy (ETV) became the relevant treatment option for non-communicating pediatric hydrocephalus. ETV success was predicted in relation to age, diagnosis, and previous shunt implantation. Radiological factors are usually taken for indication decision-making. The aim of this study is to investigate radiological signs of non-communicating hydrocephalus for ETV success in a single-center retrospective analysis.

Patients and methods
ETV interventions were collected from a 10-year period (2010–2019) from our institution. Clinical patient characteristics such as prematurity, age, diagnosis, and previous shunt treatment and follow-up in terms of possible shunt implantation or revision surgeries were investigated. Radiological data was retrieved from the in-house PACS system to analyze preoperative signs for non­communicating hydrocephalus such as ventricular size, pressure gradients at the third ventricle, and any signs of obstruction from internal towards external cerebral spinal fluid communication. Fisher’s test was used to demonstrate the significance of each individual predictor. A multivariable model was built using the backward elimination method with multiple logistic regression.

Results
From 136 ETV interventions, 95 met the inclusion criteria (age < 18 years; > 6-month follow-up; MR image data availability, treatment goal for shunt independence). In chi-square statistical evaluation of single parameters age > 6 months (OR 32.5; 95% CI 4.8–364), ventricular width (FOHR < 0.56; OR 6.1; 95% CI 2.2–16.3) and non-post-hemorrhagic hydrocephalus as underlying diagnosis (OR 13.1; 95% CI 1.9–163) showed significant increased odds ratio for shunt independence during follow-up. Logistic regression analysis for multiple parameters showed age > 6 months (OR 29.3; 95% CI 4.1–606) together with outward bulged lamina terminalis (OR 4.6; 95% CI 1.2–19.6), smaller FOHR (continuous parameter; OR 2.83 × 10−5; 95% CI 4.7 × 10−9–0.045), and non-4th-ventricular-outlet obstruction (4thVOO; OR 0.31; 95% CI 0.09–1.02) as significant factors for ETV success.

Conclusion
ETV has become a relevant treatment for non-communicating hydrocephalus, with typical MR image characteristics. Analyzing radiological markers as predictors for success smaller ventricular width and outward displaced lamina terminalis was relevant in combination with age > 6 months. Since the analysis is based on single-center experience, a larger cohort of patients with a multi-center approach should further investigate the combined clinical and radiological criteria.
Patient-specific scaphoid prosthesis: surgical technique
Authors: Honigmann Philipp , Oonk Joris , Dobbe Johannes , Strackee Simon , Streekstra Geert , Haefeli Mathias 
Published: December 2024

AbstractThe scaphoid bone is essential for wrist stability, force transmission, and movement, being crucial for maintaining carpal kinematics. In cases where the scaphoid is non-reconstructable, a complete replacement can serve as a treatment option to preserve carpal alignment and motion. This approach has evolved since its first descriptions in 1945, benefiting significantly from advancements in patient-specific implant design, additive manufacturing/3D printing, and material use in recent years. We present a technique for scaphoid replacement using a patient-specific prosthesis and reconstruction of intrinsic and extrinsic ligaments to achieve optimal stability and mobility.
Management of osteochondritis dissecans lesions of the elbow including return to sport remains variable among orthopaedic surgeons
Authors: Bowman Eric N. , Lane Gabriel , Goldfarb Charles F. , Smith Matthew V. 
Published: December 2024

Abstract
Introduction
Management of osteochondritis dissecans (OCD) lesions of the capitellum is challenging. Historically, variability exists between surgeons in the evaluation, treatment, and return to sport criteria. The purpose of this study was to define the current trends regarding evaluation, nonoperative and surgical management, and return to sport criteria for capitellar OCD lesions among surgeons.

Methods
A 21-question cross-sectional survey was administered to 24 Orthopaedic surgeons specializing in elbow OCDs. The survey included questions concerning imaging, specific non-operative treatments trialed, indications for surgery for stable and unstable lesions, preferred surgical techniques, osteochondral autograft utilization, and factors determining return to sport.

Results
Twenty-one surgeons responded (88%). The most common surgical indications for stable lesions were time (≥ 6 months, 68%) and mechanical symptoms (52%). Drilling (45%) and fragment fixation (35%) were most preferred. For unstable lesions, factors in order of importance for determining surgical procedure were lesion size, lateral wall integrity, location on capitellum, skeletal maturity, and sport. For small (< 1 cm2), centralized lesions, 81% preferred debridement with microfracture. For large (> 1 cm2), lateralized lesions, 52% preferred debridement and microfracture and 48% preferred osteochondral autograft transfer (OAT). OAT was considered for 80% of failed procedures, 47% with lateral wall involvement, and 27% > 1 cm2. Return to sport after debridement was typically 2–3 months (52%), fragment fixation was 4 months (52%), and OAT was 4–6 months, while microfracture had wide variability (3–6 months). The factors in order of importance were lack of pain, time, then imaging. Two-thirds of surgeons wait longer to release overhead athletes or gymnasts.

Conclusions
There is significant variability in the management of capitellar OCD in athletes. Small, centralized lesions are likely to be treated with debridement and microfracture with faster return to sport. Treatment of large, lateral lesions remains variable. Regarding OAT procedures, perceived morbidity, reimbursement, and limited evidence dissuade use. There is no consensus on return to sport, though lack of pain and time were most important; overhead athletes and gymnasts are restricted longer from returning to sport.
Level of Evidence
Level 5, diagnostic, cross-sectional survey.
Utility of routine X-ray surveillance following hip sonography for developmental dysplasia in children: a single-center study spanning a decade
Authors: Wolf Matthias , Haas Leon , Tsitlakidis Stefanos , Deisenhofer Julian , Horsch Axel , Hagmann Sébastien , Gather Katharina Susanne 
Published: December 2024

Abstract
Introduction
This study evaluates the necessity of routine X-ray follow-ups in children with developmental dysplasia of the hip (DDH), identified through Graf hip ultrasound, a standard component of screening in Germany. The purpose of this study was to investigate the occurrence of radiological deterioration in hips that were initially diagnosed and treated according to established guidelines within a university-based risk-enriched cohort and to identify associated risk factors.

Materials and methods
Patients diagnosed with developmental DDH from 2009 to 2018 with sonographically healthy hips (alpha > 64°) post conservative therapy and at least one follow-up X-ray by the age of two were analysed. Patients with significant comorbidities, syndromes, malformations, non-compliance with treatment, or missing X-ray data were excluded. Descriptive analysis of sonography, X-ray, and patient records were followed by univariate analysis and subsequent multiple logistic regression, identifying risk factors for severe and extreme dysplasia in X-rays.

Results
Of the 450 included hips, 254 were classified as Graf Type 2a or higher, leading to treatment. Subsequent X-rays revealed severe dysplasia in 53 hips and extreme dysplasia in seven hips. Univariate analysis identified sex, initial Graf-Type, therapy type and duration as significantly associated with pathological radiographs. A regression model identified the initial Graf type as the predominant predictor with hip types 3a and 4, cast therapy and overhead extension as independent predictors.

Conclusions
The data demonstrate pathological findings even after successful conservative treatment of DDH. Worsening of X-ray findings appear less frequent in mild dysplasia. These insights support routine radiographic follow-up assessments after successful conservative therapy. However, further dedicated studies are needed to determine whether patients with initially normal radiographs require radiographic follow-up.
The prognostic influence of hospital type, method of first histological confirmation and time to chemotherapy in patients with advanced primary ovarian cancer
Authors: Starke Olivia , Wimberger Pauline , Klotz Daniel Martin 
Published: December 2024

Abstract
Purpose
Ovarian cancer is the fifth most common cancer in women and the leading cause of death of all gynecological malignancies. Prognosis is determined by optimal surgical outcome (macroscopic complete resection) most commonly achieved in tertiary hospitals. We investigated whether tertiary versus non-tertiary hospital as the location of an initial diagnostic intervention for histological confirmation before cytoreductive surgery versus immediate primary debulking surgery impacts outcome in patients with advanced ovarian cancer.

Methods
We analyzed 115 patients who underwent cytoreductive surgery at a German tertiary center: 60 patients underwent primary debulking surgery (PDS) and 55 patients had a diagnostic intervention for histological confirmation before debulking surgery (PHC).

Results
Although there was no prognostic difference between the two subgroups, the median time to chemotherapy was longer in the PHC group (46 days) compared to the PDS group (26 days; p < 0.0001), equally seen comparing non-tertiary versus tertiary PHC groups (p: 0.0001), its impact confirmed in a multivariate analysis (PFS: HR: 1.03, 95%CI: 1.01–1.05, p: 0.007; OS: HR: 1.04, 95%CI: 1.02 –1.06, p: < 0.001) of the PHC group only. In total, 9/10 patients with port-site metastases after diagnostic laparoscopy were initially treated at non-tertiary hospitals, resulting in a lower PFS compared to patients without port-site metastases after laparoscopy (HR 0.21, 95%CI 0.06–0.733, p: 0.014).

Conclusions
In conclusion, patients with ovarian cancer undergoing treatment solely at a tertiary center have some clinical benefits and improved outcome, given the shorter time to chemotherapy and potential impact of port-site metastases. This supports centralization of oncological treatment.
Giant axonal neuropathy (GAN): cross-sectional data on phenotypes, genotypes, and proteomic signature from a German cohort
Authors: Gangfuß Andrea , Goj Guido , Polz Silke , Della Marina Adela , Hentschel Andreas , Ahlbory Katja , Deba Timo , Kotzaeridou Urania , Schuler Elisabeth , Pechmann Astrid , Diebold Uta , Kurlemann Gerhard , Heinzkyll Lucas , Schmitt Dirk , Rostasy Kevin , Ruck Tobias , Böhm Johann , Roos Andreas , Schara-Schmidt Ulrike 
Published: December 2024

Abstract
Giant axonal neuropathy (GAN) is a progressive neurodegenerative disease affecting the peripheral and central nervous system and is caused by bi-allelic variants in the GAN gene, leading to loss of functional gigaxonin protein. A treatment does not exist, but a first clinical trial using a gene therapy approach has recently been completed. Here, we conducted the first systematic study of GAN patients treated by German-speaking child neurologists. We collected clinical, genetic, and epidemiological data from a total of 15 patients representing one of the largest cohorts described thus far. Average age of patients was 11.7 years at inclusion. The most frequently reported symptoms (HPO coded) were gait disturbance and muscle weakness, abnormality of muscle size, and abnormal reflexes. In line with the frequency of homozygous variants, in five families, parents reported being at least distantly related. In 14 patients, diagnosis was confirmed by molecular genetic testing, revealing eight different GAN variants, four being reported as pathogenic in the literature. Proteomics of white blood cells derived from four patients was conducted to obtain unbiased insights into the underlying pathophysiology and revealed dysregulation of 111 proteins implicated in diverse biological processes. Of note, diverse of these proteins is known to be crucial for proper synaptic function and transmission and affection of intermediate filament organisation and proteolysis, which is in line with the known functions of gigaxonin.
Anterior segment OCT for imaging PAUL® glaucoma implant patch grafts: a useful method for follow-up and risk management
Authors: Schipper Pascal , Weber Constance , Lu Ke , Fan Siqi , Prokosch Verena , Holz Frank G. , Mercieca Karl 
Published: December 2024

Abstract
Aim
To evaluate a useful, non-contact method for the follow-up of pericardium patch graft changes in patients undergoing PAUL® Glaucoma Implant (PGI) surgery using high-resolution anterior segment optical coherence tomography (OCT) to predict tube erosions.

Methods
Prospective analysis over six months of tube pericardium patch graft thickness of PGI surgical cases at the University Eye Hospital Bonn, Germany, from November 2021 to August 2022. In all eyes, Tutopatch® (RTI Surgical, United States) pericardium was used to cover the implant intra-operatively. Anterior segment OCT (AS-OCT, Heidelberg ANTERION® Swept-Source-OCT) examinations were performed following a standardized protocol to measure quantitative and qualitative aspects of the patch grafts before surgery, and at three and six months after surgery.

Results
Twenty-six eyes of 26 patients were included. Thickness of the patch material was 1188 µm (IQR 415 µm) directly after implantation and decreased over time to 1068 µm (IQR 478 µm) at 3 months and 846 µm (IQR 677 µm) at 6 months. No significant differences between groups were shown concerning gender (p = 0.128), ethnicity (p = 1.000), age (p = 0.741), glaucoma type (p = 0.173), other concurrent diseases (p = 0.302), former glaucoma surgeries (p = 1.000) and the quadrant of implantation (p = 0.555). Five eyes developed implant exposure. When comparing eyes with and without tube exposure, no significant differences were shown in average patch thickness above the tube directly after implantation (p = 0.476). However, significant differences in average thickness were observed at 3 months (p = 0.013) and 6 months (p = 0.005).

Conclusions
Pericardial patch grafts tend to thin over time which can be assessed by AS-OCT, the latter proving to be a useful method to follow-up patients who undergo patch graft implantation during PGI surgery. This investigation could potentially help identify patients at risk of tube exposure which in turn could lead to modification of patient management. It could also possibly be used in future studies to find more suitable patch materials.
Curative treatment for oligometastatic gastroesophageal cancer– results of a prospective multicenter study
Authors: Norén N. , Rouvelas I. , Lundell L. , Nilsson M. , Sunde B. , Szabo E. , Edholm D. , Hedberg J. , Smedh U. , Hermansson M. , Lindblad M. , Klevebro F. 
Published: December 2024

Abstract
Purpose
Oligometastatic gastroesophageal cancer is a clinical entity with no standard treatment recommendation. Treatment with curative intent has recently emerged as an option for selected patients in contrast to the traditional palliative treatment strategy. This prospective study aimed to assess the safety and efficacy of combined systemic and local treatment with curative intent for patients with oligometastatic gastroesophageal cancer.

Methods
In a multicenter study, consecutive patients with gastroesophageal cancer and metastases in the liver and/or extra-regional lymph nodes were screened for inclusion. Eligible patients were offered curatively intended perioperative chemotherapy followed by surgical resection or liver ablation. Primary endpoints were treatment safety and feasibility. Secondary outcomes included postoperative mortality, treatment response, progression-free survival, and overall survival. Subgroup analyses were stratified based on oligometastatic location.

Results
A total of 29 (82.9%) patients completed treatment with surgical resection (93.1%), liver ablation (3.4%), or definitive chemoradiotherapy (3.4%). Postoperative complications were found in 19 (73.1%) patients, whereas postoperative mortality was 0%. The most common complications included infection (34.6%) and respiratory complications (34.6%). Median overall survival was 20.9 months (interquartile range 11.2–42.6) from diagnosis and 17.0 months (interquartile range 6.4–35.9) from surgery in patients who were treated with neoadjuvant chemotherapy followed by surgery. Median progression-free survival was 5.8 months (interquartile range 3.1–11.3).

Conclusion
This study found curative treatment to be a relatively safe option, with an overall survival of 20.8 months and no postoperative mortality.
Is tumour location a dominant risk factor of recurrence in early rectal cancer?
Authors: Rosén Roberto , Thorlacius Henrik , Rönnow Carl-Fredrik 
Published: December 2024

Abstract

Background
Impact of rectal tumour location on risk of lymph node metastases (LNM) and recurrence in early RC is poorly studied and elusive. Tumour location as a prognostic factor may contribute to optimise management of early RC in the future. The aim of this study was to investigate rectal tumour location as an independent predictor of oncologic outcome in early rectal cancer (RC).

Methods
Retrospective multicentre national cohort study on prospectively collected data on all patients with T1-T2 RC, undergoing surgical resection between 2009 and 2021. Tumour location was categorised as distal (0–5 cm), mid (5–10 cm), and proximal (10–16 cm), measured from the anal verge.

Results
Incidence of LNM in the 2424 included T1–T2 RC patients was 18.2%, 17.3% and 21.6% for distal, mid and proximal tumours, respectively. Recurrence was detected in 130 (7.6%) out of 1705 patients available for recurrence analyses (60-month median follow-up). Incidence of recurrence was twice as high in distal (11.4%) compared to proximal (5.6%) tumours and was 8.3% in mid located tumours. Distal (HR 2.051, CI 1.248–3.371, P < 0.05) and mid (HR 1.592, CI 1.061–2.388, P < 0.05) tumour location were significant risk factors of recurrence in uni- and multivariate Cox regression analyses.

Conclusions
This study shows that tumour location significantly affects incidence of recurrence in early RC, with an increasing risk for mid and especially distal location, found to be a predominant risk factor of recurrence. Our findings stress the need for an increased awareness on differences in oncologic outcome related to tumour location in early RC.
Comparison of intraoperative versus preoperative ERCP with laparoscopic cholecystectomy for cholecystocholedocholithiasis: a 3-year study at Kepler University Hospital
Authors: Raab Sandra , Jagoditsch Alexander , Kurz Franz , Pimingstorfer Philipp , Schimetta Wolfgang , Schöfl Rainer , Schrenk Peter , Schwinghammer Christoph , Ziachehabi Alexander , Shamiyeh Andreas 
Published: December 2024

Abstract

Background
Preoperative ERCP followed by cholecystectomy is a common treatment for cholecystocholedocholithiasis. However, intraoperative ERCP has been used more frequently over the last two decades, with few studies assessing various aspects of both methods. We evaluated and compared the management and outcomes of intraoperative ERCP and preoperative ERCP.

Methods
This is a retrospective cohort study of a prospective registry. A total of 169 patients with cholecystocholedocholithiasis underwent either intraoperative ERCP or preoperative ERCP followed by cholecystectomy. Between January 2020 and June 2023 patients were further analysed for morbidity, surgical technique, ERCP and surgical indications, length of stay and success rate of ERCP.

Results
103 patients (60.9%) underwent intraoperative ERCP and 66 patients (39.1%) an ERCP later followed by cholecystectomy. Patients with intraoperative ERCP tended to have a lower rate of post-ERCP pancreatitis (3.9% vs. 6.1%; P = 0.537), fewer ERCP complications (3.9% vs. 10.6%; P = 0.116), a reduced hospital stay (8 vs. 13.8 days; P < 0.001) and a lower cannulation failure rate of the common bile duct during ERCP (1.9% vs. 6.1%; P = 0.088).

Conclusions
Our study identified several advantages of intraoperative simultaneous ERCP over upfront ERCP, suggesting that intraoperative ERCP may be a viable and safe option for the comprehensive management of cholecystocholedocholithiasis.