bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanomedicines for Subcellular Targeting: The Mitochondrial Perspective
Authors: Oladimeji Olakunle , Akinyelu Jude , Singh Moganavelli 
Published: November 2019

Background:
Over the past decade, there has been a surge in the number of mitochondrialactive
therapeutics for conditions ranging from cancer to aging. Subcellular targeting interventions
can modulate adverse intracellular processes unique to the compartments within the cell. However,
there is a dearth of reviews focusing on mitochondrial nano-delivery, and this review seeks to fill this
gap with regards to nanotherapeutics of the mitochondria.

Methods:
Besides its potential for a higher therapeutic index than targeting at the tissue and cell levels,
subcellular targeting takes into account the limitations of systemic drug administration and significantly
improves pharmacokinetics. Hence, an extensive literature review was undertaken and salient
information was compiled in this review.

Results:
From literature, it was evident that nanoparticles with their tunable physicochemical properties
have shown potential for efficient therapeutic delivery, with several nanomedicines already approved
by the FDA and others in clinical trials. However, strategies for the development of nanomedicines
for subcellular targeting are still emerging, with an increased understanding of dysfunctional
molecular processes advancing the development of treatment modules. For optimal delivery, the design
of an ideal carrier for subcellular delivery must consider the features of the diseased
microenvironment. The functional and structural features of the mitochondria in the diseased state are
highlighted and potential nano-delivery interventions for treatment and diagnosis are discussed.

Conclusion:
This review provides an insight into recent advances in subcellular targeting, with a
focus on en route barriers to subcellular targeting. The impact of mitochondrial dysfunction in the
aetiology of certain diseases is highlighted, and potential therapeutic sites are identified.
Biomarkers of Cardiovascular Risk in Obese Women and their Relationship with Zinc Status
Authors: Severo Juliana S. , Morais Jennifer B.S. , Beserra Jessica B. , Clímaco Cruz Kyria J. , de Oliveira Ana R.S. , dos Santos Loanne R. , de Matos Neto Emídio M. , de Macedo George F.S. , de Jesus e Silva de Almendra Freitas Betania , Henriques Gilberto S. , do Nascimento Marreiro Dilina 
Published: November 2019

Background:Excessive adipose tissue, in the case of common obesity, has been associated with an endocrine-metabolic alteration that contributes to a manifestation of dyslipidemia. To identify mechanisms which are involved in disorders of lipid metabolism, several nutrients have been studied, especially zinc, which act by regulating transcription factors that are important for synthesis and oxidation of lipids and act as an anti-inflammatory and antioxidant nutrient. Thus, the study makes an assessment of the zinc status and biomarkers of cardiovascular risk in obese women.Methods:A case-control study enrolling obese (body mass index (BMI) ≥35 kg/m²) and eutrophic (BMI 18.5-24.9 kg/m²) Brazilian women was conducted. Dietary zinc intake was assessed by the three-day food registry. Plasma, erythrocyte and urinary zinc concentrations were determined by inductively coupled plasma optical emission spectrometry. Cardiovascular risk was assessed by plasma concentrations of lipid fractions, and by anthropometric measures.Results:Both groups showed a dietary zinc intake above the recommendations, with no statistical difference between them (p >0.05). Mean plasma and erythrocyte zinc concentrations were significantly reduced in obese women, compared to the control group (p <0.05). Urinary zinc excretion was significantly higher in obese women (p <0.05), who also had a significantly higher cardiovascular risk when compared to the control group (p <0.05). An inverse correlation between dietary zinc intake and waist-hip ratio was found in obese women.Conclusion:Obese women presented zinc redistribution characterized by reduced concentrations in plasma and erythrocytes, dietary zinc intake above the recommended, and increased zinc excretion in the urine. This study shows dyshomeostasis of zinc in obesity, a possible role in adiposity control and, consequently, its protective role against cardiovascular risk, due to its influence on risk biomarkers, such as waist-hip ratio.
A Review of the Impact of Food Policies on Food Security Status and Healthy/Unhealthy Food Consumption
Authors: Mohajeri Mahsa , Pourfarzi Farhad , Ghahremanzadeh Mohammad , Nemati Ali , Barzegar Ali 
Published: November 2019

Background:
Food insecurity refers to a household’s financial inability to access adequate
food. Food subsidy programs are the right strategies that have been undertaken for many years in
some countries.

Aim:
This study aims to summarize and compare the impact of some subsidy programs on food security
as a narrative review.

Methods:
Community-based studies analyzing the impact of food policies on food security status and
healthy/unhealthy food consumption were reviewed. Our search keywords included food tax,
healthy/unhealthy food, food security, food subsidy, targeted subsidy, and Iran.

Results and conclusion:
Some subsidy programs aim to improve food security and nutritional status
of low-income individuals. Developing countries, for the improvement of food security and hunger,
use some food subsidy programs that can improve the food security status. One of the most used programs
is a food subsidy program in schools. Unfortunately, the targeted subsidy policy in Iran has
affected the nutritional status and food security of households, therefore, it is necessary to implement
a food subsidy program for low-income families. Fruits and vegetable subsidies can increase their
consumption. Unhealthy food consumption decreases by implementing food tax programs, especially
if the number of tax increases. In general, cash subsidies are more beneficial in improving the nutritional
status.
Education Into Policy: Embedding Health Informatics to Prepare Future Nurses—New Zealand Case Study
Authors: Honey Michelle , Collins Emma , Britnell Sally 
Published: November 2019

Background
Preparing emerging health professionals for practicing in an ever-changing health care environment along with continually evolving technology is an international concern. This is particularly pertinent for nursing because nurses make up the largest part of the health workforce.

Objective
This study aimed to explore how health informatics can be included in undergraduate health professional education.

Methods
A case study approach was used to consider health informatics within undergraduate nursing education in New Zealand. This has led to the development of nursing informatics guidelines for nurses entering practice.

Results
The process used to develop nursing informatics guidelines for entry to practice in New Zealand is described. The final guidelines are based on the literature and are refined using an advisory group and an iterative process.

Conclusions
Although this study describes the development of nursing informatics guidelines for nurses entering practice, the challenge is to move these guidelines from educational rhetoric to policy. It is only by ensuring that health informatics is embedded in the undergraduate education of all health professionals can we be assured that future health professionals are prepared to work effectively, efficiently, and safely with information and communication technologies as part of their practice.
Pengembangan Model Pengukuran Kesiapan Industri 4.0 Untuk Perusahaan Manufaktur di Indonesia
Authors: Tan Hauw Sen Rimo , Andhika Aditya , Ariyanti Francisca Dini , Soebandrija Khristian Edi Nugroho 
Published: November 2019

Nowadays, manufacturing companies in Indonesia are facing a great challenge in Industry 4.0 era. Manufacturing companies perceive Industry 4.0 is complex and could disturb their business process with uncertainty in results by implementing it. In other side, manufacturing companies also have difficulty in assessing their readiness to start Industry 4.0 transformation process and fail to prepare strategies and action plans clearly. This research developed a measurement model of Industry 4.0 readiness with 2 aspects, 5 dimensions and 20 variables that could be used by manufacturing companies to asses their current state. The dimensions “Awareness” and “Leadership and Strategy” are used to measure company readiness in “Knowledge” aspect, while the dimensions “People and Culture”, “Technology” and “Operation” are used to measure company readiness in “Resources Capability” aspect. The result of the measurement categories the company in 4 level of readiness, i.e.: “Not Ready”, “Conditional Ready”, “Basic Readiness” and “Fully Ready”. This model has been tested and used to measure Industry 4.0 readiness for an electronic manufacturing company located in Jabodetabek and showed that the model is easy and practical to be used in a real manufacturing company. Keywords: Industry 4.0, readiness measurement, readiness model, readiness index
PENERAPAN MANAJEMEN PENINGKATAN MUTU DI MADRASAH ALIYAH NEGERI KABUPATEN KAMPAR
Authors: Mardalisnar M. , Affandi Muslim , Univsritas Islam Negeri Sultan Syarif Kasim Riau I. 
Published: November 2019

Manajemen yang diterapkan Nabi Muhammad SAW memang tidak secanggih manajemen modern, tapi sejarah membuktikan bahwa manajemen yang beliau terapkan itu sangat efektif. M. Ahmad Abdul Jawwad, mengemukakan bahwa terdapat enam rahasia keunggulan manajemen Rasulullah, yaitu:1) kemampuan memotivasi tim, 2) simple dalam memotivasi, 3) kemampuan berkomunikasi, 4) kemampuan mendelegasikan dan membagi tugas, 5) efektif dalam memimpin rapat, dan 6) kemampuan mengontrol dan mengevaluasi.Penelitian ini bertujuan untuk mengetahui penerapan manajemen peningkatan mutu di Madrasah Aliyah Negeri Kabupaten Kampar” Rumusan Masalah yang diajukan adalah: 1) Bagaimana Penerapan Manajemen peningkatan mutu di Madrasah Aliyah Negeri Kabupaten Kampar? 2) Apa sajakah faktor yang menunjang Penerapan Manajemen peningkatan mutu di Madrasah Aliyah Negeri Kabupaten Kampar? 3) Apa sajakah faktor yang menghambat Penerapan Manajemen peningkatan mutu di Madrasah Aliyah Negeri Kabupaten Kampar? Analisa yang digunakan dalam penelitian ini adalah analisa kualitatif, yaitu analisis dan interpretasi dilakukan secara kritis. Dengan menggunakan teknik deskriptif analitis yaitu mendeskripsikan maupun mengklasifikasikan data dan kemudian disusul interpretasi terhadap hasil pemikiran.Hasil penelitian yang dapat penulis identifikasi adalah; Pertama, Untuk tercapainya peningkatan mutu pendidikan dan layanan yang cepat, tepat dan efesien perlu terus diusahakan adanya keteladanan, kesadaran dan kerjasama yang baik dari masing-masing jajaran MAN se-Kabupaten kampa, bahwa apapun yang ada di MAN se-Kabupaten kampar harus menjadi yang terbaik, sebagai manajer kepala MAN Negeri di Kabupaten Kampar telah mampu dalam meningkatkan kompetensi guru di lingkungan MAN mampu mengelola lembaga pendidikan tersebut sehingga tercapai tujuan yang diinginkan. sebagai leader/ pemimpin, kepemimpinan kepala MAN menjadi teladan bagi warga MAN dan mampu menggerakkan warga MAN dalam bekerjasama untuk mencapai tujuan pendidikan Kedua, Faktor yang menunjang Penerapan Manajemen peningkatan mutu di Madrasah Aliyah Negeri Kabupaten Kampar program peningkatan kualifikasi guru, peningkatan personil madrasah secara moril atau dalam hal keagamaan, kekeluargaan antara guru dan masyarakat sekitar yang erat, serta sumbangsih masyarakat sekitar madrasah dalam meningkatkan kualitas madrasah secara menyeluruh. Sedangkan faktor penghambat dalam mencapai keberhasilan kompetensi guru di lingkungan MAN Negeri di Kabupaten Kampar tersebut tidak ada karena sarana prasarana untuk peningkatan bakat siswa, sumber daya manusia atau guru sudah lengkap.
Relationship External Factors with Internet Addiction in Adolescent Age 15-18 Years
Authors: Ibrahim Masdum , Suryani Suryani , Sriati Aat 
Published: November 2019

The internet is one form of evolution in the development of communication and technology that affects humans. One result of the internet is a significant change in the pattern of primary social interactions between individuals. The convenience provided by the internet indirectly causes individuals to have high levels of addiction to the internet and tend to show symptoms of addiction. In Indonesia, internet addiction is mainly found in groups of adolescents aged 15-22 years. This study aims to determine the relationship of external factors: academic stress, family attachments and peers with internet addiction in high school adolescents aged 15-18 years. The study design was carried out using a correlational research design with a cross sectional approach. Respondents who contributed in this study were 97 senior high school students. With sample selection, random sampling is done. The statistical test used was chi-square. The results of this study prove that academic stress has a significant relationship with internet addiction value X2 = 7.91 and P = 0.019 <0.05. Family attachments did not have a relationship with internet addiction, the value of X2 = 0.046 and P 1,000> 0.05 and peers did not have a relationship with internet addiction X2 = 0.241 and P = 0.657. Based on the results of this study, it can be said that the school through the school committee to share information or share about the problem of teenagers who experience academic stress, internet addiction, impact and how to overcome them also evaluate the learning process.
<p>Pengetahuan pekerja sektor informal bukan pemilik kartu Badan Penyelenggara Jaminan Sosial mengenai Badan Penyelenggara Jaminan Sosial Kesehatan </p><p> Knowledge of Social Security Agency (BPJS) non-cardholder informal sector workers regarding the Healthcare and Social Security Agency (BPJS Kesehatan)</p>
Authors: Petrina Yoanita , Zubaedah Cucu , Susilawati Sri 
Published: November 2019

Pendahuluan: Hak untuk sehat merupakan hak asasi manusia yang diakui di Indonesia. Pemerintah melaksanakan program Jaminan Kesehatan Nasional (JKN) untuk mewujudkan hak untuk sehat melalui Badan Penyelenggara Jaminan Sosial (BPJS). Rendahnya partisipasi pekerja sektor informal karena kurangnya kesadaran dan pengetahuan tentang konsep dasar penjaminan kesehatan. Tujuan penelitian adalah mengetahui pengetahuan pekerja sektor informal bukan pemilik kartu BPJS mengenai BPJS Kesehatan. Metode: Penelitian ini merupakan penelitian deskriptif dengan metode survei. Penelitian dilakukan dengan memberikan kuesioner pengetahuan BPJS Kesehatan. Sampel penelitian adalah pekerja sektor informal bukan pemilik kartu BPJS Kesehatan. Hasil: Hasil penelitian menunjukkan sebanyak 7,7% responden berpengetahuan cukup dan 92,3% berpengetahuan kurang tentang BPJS Kesehatan. Nilai rata-rata dari seluruh responden adalah 38,61 yang termasuk kategori kurang). Simpulan: Pengetahuan pekerja sektor informal bukan pemilik kartu BPJS Kesehatan mengenai BPJS Kesehatan tergolong dalam kategori kurang.Kata kunci: BPJS Kesehatan, JKN, pengetahuan, pekerja sektor informal. ABSTRACTIntroduction: The human right to health is a recognised human right in Indonesia. The government implements the Universal Healthcare Program (JKN) to actualise the human right to health through the Social Security Agency (BPJS). The low participation of informal sector workers is caused by lack of awareness and knowledge on the basic concepts of health insurance. The purpose of this study was to determine the knowledge of Social Security Agency (BPJS) non-cardholder informal sector workers regarding the Healthcare and Social Security Agency (BPJS Kesehatan). Methods: This research was a descriptive study with a survey method. The study was conducted by giving questionnaire regarding knowledge of Healthcare and Social Security Agency. The research sample was Social Security Agency (BPJS) non-cardholder informal sector workers. Results: The results showed that 7.7% of respondents had sufficient knowledge and 92.3% had less knowledge regarding the Healthcare and Social Security Agency. The average value of all respondents was 38.61 which included in the less category. Conclusion: Knowledge of Social Security Agency non-cardholder informal sector workers regarding the Healthcare and Social Security Agency belongs to the less knowledge category.Keywords: Healthcare and Social Security Agency, Universal Healthcare Program, knowledge, informal sector workers.
Comparison of glucose concentrations in serum, plasma, and blood measured by a point-of-care glucometer with serum glucose concentration measured by an automated biochemical analyzer for canine and feline blood samples
Authors: Lechner Matthew J. , Hess Rebecka S. 
Published: November 2019

Abstract

OBJECTIVE
To determine the correlation between glucose concentrations in serum, plasma, and blood measured by a point-of-care glucometer (POCG) and serum glucose concentration measured by an automated biochemical analyzer (ABA; gold standard).

SAMPLE
152 canine and 111 feline blood samples.

PROCEDURES
For each sample, the glucose concentration in serum, plasma, and blood was measured by a POCG and compared with the ABA-measured glucose concentration by means of the Lin concordance correlation coefficient. Results were summarized by species for all samples and subsets of samples with hyperglycemia (ABA-measured glucose concentration > 112 mg/dL for dogs and > 168 mg/dL for cats) and pronounced hyperglycemia (ABA-measured glucose concentration > 250 mg/dL for both species). The effect of PCV on correlations between POCG and ABA measurements was also assessed.

RESULTS
Hyperglycemia and pronounced hyperglycemia were identified in 69 and 36 canine samples and 44 and 29 feline samples, respectively. The POCG-measured glucose concentrations in serum, plasma, and blood were strongly and positively correlated with the gold standard concentration. The PCV was positively associated with the correlation between the POCG-measured blood glucose concentration and the gold standard concentration but was not associated with the correlations between the POCG-measured glucose concentrations in serum and plasma and the gold standard concentration.

CONCLUSIONS AND CLINICAL RELEVANCE
Results indicated that POCG-measured glucose concentrations in serum, plasma, and blood were strongly correlated with the ABA-measured serum glucose concentration, even in hyperglycemic samples. Given the time and labor required to harvest serum or plasma from blood samples, we concluded that blood was the preferred sample type for use with this POCG.
Sistem Pendeteksi Kebakaran Menggunakan Raspberry Pi Berbasis Android
Authors: Pande Agustiana Putra I Wayan , Piarsa I Nyoman , Suar Wibawa Kadek 
Published: November 2019

Kebakaran adalah salah satu bencana yang sering terjadi di masyarakat dapat mengakibatkan kerugian yang cukup besar jika tidak ditangani dengan cepat. Kasus kebakaran yang sering terjadi menyebabkan dibutuhkan adanya sistem yang mampu mendeteksi adanya kebakaran dan memberikan informasi kepada pengguna dari jarak jauh untuk mengurangi dampak dari kebakaran. Teknologi yang dapat digunakan adalah teknologi Internet of Things yang merupakan sebuah teknologi yang memungkinkan benda fisik untuk saling berkomunikasi melalui internet. Sistem pendeteksi kebakaran ini menggunakan tiga sensor yang berfungsi untuk mendeteksi adanya api, asap, dan suhu, serta menggunakan Raspberry Pi sebagai mikrokontroler yang berfungsi untuk memproses data masukan dari sensor. Hasil pengujian menunjukkan bahwa sistem mampu memberikan informasi melalui aplikasi Android jika terdeteksi adanya api, asap kebakaran, dan suhu ruangan yang cukup tinggi. Sistem juga melakukan pencegahan awal kebakaran dengan memutuskan aliran listrik dan menyemprotkan air ke sumber api.
Kata kunci: Internet of Things, Deteksi Kebakaran, Raspberry Pi, Mikrokontroller, Android.
Aplikasi Deteksi Tumpahan Minyak dengan Interpretasi Citra Satelit Landsat 8
Authors: Lamrotua Sihombing Veranita , Nurweda Putra I Dewa Nyoman , Arya Sasmita Gusti Made 
Published: November 2019

Tumpahan minyak akibat kebocoran pipa pada tahun 2015 menyebarkan minyak di sepanjang perairan cilacap dan menyebabkan tercemarnya perairan cilacap yang mengancam kelangsungan biota hidup di sekitarnya. Tumpahan minyak berhasil dideteksi oleh satelit Landsat 8 dan melalui sistem penginderaan jauh dapat diketahui persebaran tumpahan minyak untuk mempermudah proses penanggulangan dengan memperhitungkan Oil Spill Dispersant yang dibutuhkan. Tujuan dari penelitian ini adalah merancang sebuah aplikasi penginderaan jauh untuk menghitung luas persebaran tumpahan minyak dengan menerima input berupa data citra Landsat 8 dan metadata. Pengolahan citra menggunakan dua algoritma untuk membandingkan perbedaan hasil visualisasi yang di tampilkan. Algoritma yang digunakan adalah algoritma Thresholding dan Oil Spill Index. Aplikasi bekerja secara otomatis melakukan pengolahan citra untuk menghasilkan visualisasi dan persebaran tumpahan minyak.
Kata Kunci : Oil Spill Index, Algoritma Thresholding, Tumpahan Minyak
Mengetahui Tingkat Kematangan Aplikasi pada Start up IT Menggunakan Metode CMMI dan TMMi
Authors: Made Novita Desak , Made Sukarsa I , Ketut Adi Purnawan I 
Published: November 2019

Perkembangan teknologi informasi menyebabkan perusahaan atau organisasi mengembangkan perangkat lunak secara terus menerus. Salah satunya start up IT yang memperhatikan produk yang dibuat sehingga sesuai dengan kebutuhan pengguna. Proses pembuatan serta proses pengujian menjadi hal penting dalam melakukan pengembangan sistem. CMMI dan TMMi merupakan solusi untuk dapat mengetahui tingkat kematangan dari proses yang telah dilakukan. Penelitian dilakukan pada 11 kelompok start up IT dengan wawancara serta penyebaran kuesioner. Pengukuran terhadap tingkat kematangan mendapatkan hasil yang berbeda antara CMMI dan TMMi. Tingkat kematangan dengan menggunakan CMMI menghasilkan level 2 (Managed) sedangkan dengan TMMi menghasilkan 6 team mendapat level 3, 3 team berada pada level 2 dan 2 team berada pada level 1.
Kata Kunci: Audit TI, Metode CMMI, Metode TMMi, Start up IT, Tingkat Kematangan
Kebutuhan Air untuk Tanaman Terung ( Solanum melongena. L) pada Lempung Liat Berpasir di Tanah Ultisols
Authors: Shanti Ratna 
Published: November 2019

The purpose of this study was to determine optimum water requirement of eggplant (Solanummelongena L) onsandy clay loam soil of Ultisols during it growth period. The experiment was conducted on 5th May to 27thAgust2017 in glass house Faculty of Agiculture, Mulawarman University, Samarinda. The pot experiment was designed Completely Randomized Design that consisted of four treatments level with seven replications. Treatment based on water avaibility (WA), those are : A = 494 ml (50 % WA), B = 670 ml (75 % of WA) C = 846 ml ( 100 % of WA) and D = 1022 ml ( 125 % of WA).Each experiment pot contained 10 kg dried soil. The treated pots(after watering) have weight respectively, A= 10494 g, B = 10670 g, C= 10846 g, and D= 11022 g. These pots will be weighted every daycontinouslyduring plant growth and maintained those pot weight respectively.Vegetative and generative data were collected and statistical analyzed using variance analysis. If the treatments showed significant different effect, the statistical analysis of those treatment continued by Least Significant Different (LSD) test at 5% level to find out the optimum water requirement level. The results of the experiment showed that treatments of watering was significant effect on the average of vegetative parameters, (vegetative growth i.e.plant height at the age 20, 40, and 60 days, blooming after planting.) and significant effect for generative parameters (fruit number, length and fruit weight).The optimum water requirement for eggplant at 506 ml pot-1 therefore during growth period eggplant needs 40,731 ml of waterfor maximum yield.