bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antitumor Effects of Triterpenes in Hepatocellular Carcinoma
Authors: Sureda Antoni , Martorell Miquel , Capó Xavier , Monserrat-Mesquida Margalida , Quetglas-Llabrés Maria Magdalena , Rasekhian Mahsa , Nabavi Seyed M. , Tejada Silvia 
Published: June 2020

Background:
Triterpenes are a large group of secondary metabolites mainly produced by
plants with a variety of biological activities, including potential antitumor effects. Hepatocellular carcinoma
(HCC) is a very common primary liver disease spread worldwide. The treatment can consist of
surgical intervention, radiotherapy, immunotherapy and chemotherapeutic drugs. These drugs mainly
include tyrosine multikinase inhibitors, although their use is limited by the underlying liver disease and
displays side effects. For that reason, the utility of natural compounds such as triterpenes to treat HCC is
an interesting line of research. No clinical studies are reported in humans so far.

Objective:
The aim of the present work is to review the knowledge about the effects of triterpenes as a possible coadjuvant tool to treat HCC.

Results:
In vitro and xenograft models have pointed out the cytotoxic and anti-proliferative effects as
well as improvements in tumor growth and development of many triterpenes. In addition, they have also
shown to be chemosensitizing agents when co-administered with chemotherapeutic agents. The mechanisms
of action are diverse and involve the participation of mitogen-activated protein kinases, including
JNK, p38 MAPK and ERK, and the survival-associated PI3K / Akt signaling pathway. However, no
clinical studies are still reported in humans.

Conclusion:
Triterpenes could become a future strategy to address HCC or at least improve results
when administered in combination with chemotherapeutic agents.
Pyrazole Derivatives of Medically Relevant Phenolic Acids: Insight into Antioxidative and Anti-LOX Activity
Authors: Milovanović Vesna , Petrović Zorica D. , Novaković Slađana , Bogdanović Goran A. , Simijonović Dušica , Mladenović Milan , Branković Jovica , Petrović Vladimir P. 
Published: June 2020

Background:
From the point of view of medicinal chemistry, compounds containing phenolic
and pyrazolic moiety are significant since they are often constituents of bioactive compounds.

Objective:
The aims of this study were to synthesize pyrazole derivatives of medically relevant phenolic
acids, confirm their structure, and evaluate their antioxidative and anti-LOX activities.

Methods:
Phenolic pyrazole derivatives were obtained, starting from esters of medically relevant phenolic
acids. The structures of all obtained compounds were determined by NMR and IR spectroscopy, and
UV-Vis spectrophotometry. In addition, the single-crystal X-ray diffraction was used. Pyrazole derivatives
were tested for their in vitro antioxidative (DPPH assay), and lipoxygenase (LOX) inhibitory activities.
Radical quenching mechanism was estimated using DFT and thermodynamic approach, while
molecular docking was used to estimate the binding mode within the enzyme.

Results:
Pyrazole derivatives were obtained in high yields. The crystal structure of a new compound 3e
was determined. Pyrazole derivative with catechol moiety 3d exhibited excellent radical scavenging activity,
while compound 3b exhibited the best anti-LOX activity. Molecular docking study revealed that
there is no direct interaction of any ligand with the active site of LOX-Ib, but pyrazoles 3a-e behave as
inhibitors blocking the approach of linoleic acid to the active site.

Conclusion:
In this research, protocatechuic and vanillic acid pyrazole derivatives have been obtained for the first time. In vitro antioxidative assay suggests that pyrazole derivate of protocatechuic acid is a powerful radical scavenger, while anti-LOX assay indicates
a pyrazole derivative with 4-hydroxyphenyl moiety.
Socio-Economic Situation and Substance Use Disorder Influences on Safety Practices among Truckers
Authors: Ajayi Adeyinka P. , Mazinyo Sonwabo P. 
Published: June 2020

Background:The study examined the nexus between Social Economic Situation (SES) and Substance Use Disorder (SUD) and the influence the two exerted on willingness to comply with Health Safety and Environment (HSE) guiding the conveyance of petroleum products among truckers in Ibadan metropolis, Nigeria.Methods:Multistage and simple random sampling techniques were utilized to obtain the 265 respondents who are professional haulers and necessary information on the study objectives were obtained through self-reporting designed questionnaire. Bivariate statistical analysis and Logistic Regression Model were also used in ascertaining the existence of relationships among the dependent and independent variables.Results:The result from the bivariate analysis showed the existence of an association between two SES variables of age [X2(9) 17.05, p=0.04] and literacy level[X2 (9) 41.36 p=0.00] and SUD. While the marital status of the respondents did not significantly influence the incidences of SUD [X2(9) 9.841p=0.36].Furthermore, a Logistic Regression Model (LRM) examined the relationship between dichotomous dependent variable (compliance or non-compliance to HSE stipulations guiding the conveyance of petroleum products) and the different independent explanatory variables (Age, Marital Status, Educational Status and SUD). The Wald criterion demonstrated that marital status (p=.000), educational status (p=.000) and attitude to SUD (p=.000) all made significant contributions to the prediction (compliance) while age (p=.861) was not a significant predictor.Conclusion:The study recommends the importance of non-economic factors (like literacy and marital status) in the achievement of sustainable HSE stipulations guiding the conveyance of petroleum products.
Apelin/Apelin Receptor System: Molecular Characteristics, Physiological Roles, and Prospects as a Target for Disease Prevention and Pharmacotherapy
Authors: Kinjo Toshihiko , Higashi Hiroshi , Uno Kyosuke , Kuramoto Nobuyuki 
Published: June 2020

Background:
Among the various orphan G protein-coupled receptors, apelin receptor (APJ), originally identified in the
human genome as an orphan G-protein-coupled receptor, was deorphanised in 1998 with the discovery of its endogenous ligand, apelin. Apelin and APJ mRNA are widely expressed in peripheral tissues and the central nervous system in mammals.

Objective:
In this review, we discuss the characteristics, pharmacology, physiology, and pathology of the apelin/APJ system in mammals.

Conclusion:
Several physiological roles of the apelin/APJ system have been reported, including in homeostasis, cardiovascular
maintenance, angiogenesis, and neuroprotection. In cellular signaling, apelin has been shown to drive the PI3K/Akt, MAPK, and PKA
signaling pathways, leading to cell proliferation and protection from excitotoxicity. Apelin is also found in breast milk; therefore,
apelin is believed to contribute to the establishment of the infant immune system. Furthermore, activation of the apelin/APJ system is
reported to restore muscular weakness associated with aging. Thus, the apelin/APJ system represents a novel target for the prevention
of several important cardiovascular and neurodegenerative diseases and the maintenance of health during old age.
Energy Efficient Configurable Layout of Logic Block in QCA Frame Work for an FPGA
Authors: Das Kunal , Sadhu Arindam , Sarkar Rimpa Dey , De Debashis , Kanjilal Maitreyi Ray 
Published: June 2020

Aims:
Embedded system plays a vital role in today’s life. Hence, our interest is in areadelay-
energy efficient embedded system design in post-CMOS technology, i.e., QCA.

Objectives:
The research is focused on efficient area-delay-energy Configurable Logic Block (CLB)
design for Field-Programmable Gate Array architecture (FPGA) with successful simulation-based on
next-generation technology, Quantum-dot cellular automata.

Methods:
Each proposed circuit is designed on post CMOS 4 dot 2 electron technology, i.e. QCA
(Quantum dot Cellular Automata), is adopted in circuit implementation due to low power dissipation,
high clock frequency and high package density. QCADesigner is used to verify the functionality of
every circuit. QCAPro tool is used for determining power dissipation.

Results:
In contrast, a new approach of using de-multiplexer replacing the decoder has been introduced
that results in the reduction of the average energy dissipation by almost 57%. A NOR based D
flip-flop memory architecture and multiplexer are also used in the lookup table for the configurable
logic block. The proposed architecture thus reduces the overall latency. The proposed CLB consists of
6356 QCA cells covering 7.44 um2 area. Write and read latency of proposed CLB are 12 and 7.25
QCA clock, respectively.

Conclusion:
The present paper concludes that read and write latency reduction occurs; average energy
dissipation, leakage, and switching energy dissipation are reduced in a large amount resulting in an
advantage of the overall minimization of the latency for the proposed CLB in the process.
Whither the Protection for Cyberstalking Victims? Some evidence from Malaysia
Authors: Hamin Zaiton , Wan Rosli Wan Rosalili 
Published: June 2020

Cyberstalking leads to a chain of reactions such as identity theft, rape, and even murder. Despite the severe ramifications of cyberstalking, the perception of the adequacy of the law and the legal protection for victims remain ambiguous. This paper aims at examining the perception of the criminalisation of such crime, the gendered nature of such crime and the attendant legal protection for its victims. This paper adopts a qualitative methodology. The preliminary findings revealed that such crime is not considered as a gendered crime and there exists ambivalence on the perception of the crime and the legal protection of victims.
Keywords: Cyber Stalking, Criminalisation, Gender, Secondary Victimisation, Victim-Blaming Mentality.
eISSN: 2398-4287 © 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.DOI: https://doi.org/10.21834/ebpj.v5iSI1.2297
A Conceptual Framework of Design and Material Process of Bagasse for Furniture Application
Authors: Safian Shahril , Ahmad Mohammad Azroll , Bahari Shahril Anuar , Hassan Oskar Hasdinor 
Published: June 2020

This conceptual framework uses bagasse as potential material for furniture design application. Bagasse has been used as an industrial material manufacturing process, some information detected in furniture manufacturing literature. Aims, to identify bagasse in the form of biocomposite material that able used in furniture application. This research was undertaken, where research methods were developed and the material was tested, documented and analysed to inform this biocomposite in furniture design development process. The objective provided new knowledge on bagasse as potential material for furniture design application. This paper acts as material processing outlines and provides preliminary evaluation for final phase results.
Keywords: Conceptual framework; material process; bagasse; furniture design.
eISSN: 2398-4287 © 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open-access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. DOI: https://doi.org/10.21834/ebpj.v5iSI1.2304
Characteristic of Local Pelangi Cloth Motifs
Authors: Samin Mohd Azhar , Legino Rafeah 
Published: June 2020

‘Pelangi’ cloth flourished locally circa 18th century. Began to decline then extinct due to the development of the Batik industry around the 1930s. In the 1960s, the tie and dye textiles were spread across the world that often mistaken by the community as ‘Pelangi’ cloth, although the design characteristics were different. The objectives of this study are to identify the elements and to show how the textile motifs design features are. This research used field study methods, interviews and library studies. The novelty of this study is to reveal the actual character to avoid misinterpretation and misperception of the community.
Keywords: Characteristic, Cloth, Local ‘Pelangi’, Motif.
eISSN: 2398-4287 © 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. DOI: https://doi.org/10.21834/ebpj.v5iSI1.2308
Individualized Apartment Accommodation for People With Intellectual Disability: Protocol for a Qualitative Study Examining the Well-Being and Support Outcomes Linking Housing and Health
Authors: Carnemolla Phillippa 
Published: June 2020

Background
Understanding the outcomes associated with both receiving and providing support to people with intellectual disability in specific settings can facilitate the alignment of health providers, community care providers, architects, and urban planners to strengthen levels of autonomy and community participation of people with intellectual disability living in the community. This study explores the impact of providing support (available 24 hours a day) for people with intellectual disability in a high-density apartment. It seeks the perspectives of people with intellectual disability who have moved into an apartment from a group home (where 4-6 people with disability live), their families, and support staff. It will enable comparison between two models of supported accommodation, group homes and individualized apartments, in a community setting.

Objective
The aims of this study are to explore the impact of an individualized apartment model of supported accommodation in a high-density setting on the well-being, autonomy, and participation of people with intellectual disability living and receiving support; the experience of providing care or support; and how this setting impacts the logistics of how quality support is provided.

Methods
Qualitative research methods were employed as the primary means of collecting and analyzing data. There are two main sources of data in this study: (1) semistructured interviews with participants in up to 3 waves (pre, post 1, and post 2) and (2) pre- and postoccupancy evaluation data on the design, layout, and location details of the built environments. Coded interview data will be paired with pre- and postoccupancy evaluations of the two accommodation settings.

Results
As of May 2020, we have recruited 55 participants. There have been 96 interviews conducted in 2 waves with people who have moved into supported accommodation, families, and staff. Collected data are currently being analyzed. We expect the results of the trial to be published in a peer-reviewed journal in late 2020.

Conclusions
This paper sets out a study of an alternative housing and support model for people with intellectual disability. It will capture personal experiences of people with intellectual disability receiving support in an apartment compared to their experiences in a group home. It will also capture the experiences of support staff working in the new setting and reveal how this differs from a group home setting. The inclusion of pre (group home) and post (apartment integrated into a community setting) measures addresses evaluative and comparative questions around the nature and impacts of the small-scale apartment and support model for both those who live and receive support, and those who support them.

International Registered Report Identifier (IRRID)
DERR1-10.2196/18248
FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF LAMOTRIGINEUSING DISCRETE SUPER DISINTEGRANTS AND COPROCESSED EXCIPIENTS
Authors: POONURU RAJASEKHAR , CHERUKU ROHINI , JULURI PAVAN , JABEEN KHADEERA , SREERAMULA SWETHA , BANDARI SNEHA , MADUPU AKHILA 
Published: June 2020

Objective: The present study was designed to formulate and evaluate the orodispersible tablets of lamotrigine after enhancing its solubility.
Methods: Lamotrigine was made into an inclusion complex with eudragit E 100 my kneading and mass extrusion method and later this mixture is compressed into orodispersible tablet using various super disintegrants and co-processed excipients to reduce the disintegration time for providing prompt action through rapid drug release.
Results: Lamotrigine ODTs containing F-melt (F1-3%, F2-5%) dispersed in lesser time of (9±0.11) and (21±0.58) compared to formulations with polyplasdone XL-10 and primellose as super disintegrants respectively with F1 showing short wetting time. The water absorption was also was found to be more for formulation with 3% F-Melt.
Conclusion: Lamotrigine orodispersible tablets were prepared by direct compression technique by using 3% and 5% of three super disintegrants (f-melt, primellose and polyplasdone XL-10). Disintegration time of F1 (3% f-melt) formulation was found to be least (7 sec).
STUDY OF POTENTIAL DRUG INTERACTIONS AMONG EIGHT MAJOR DEPARTMENTS-GENERAL MEDICINE, ORTHOPEDICS, GYNECOLOGY, PULMONOLOGY, GENERAL SURGERY, PSYCHIATRY, OTOLARYNGOLOGY AND DERMATOLOGY OF A TERTIARY CARE TEACHING HOSPITAL IN SOUTHERN INDIA
Authors: JABEEN TALHA , KHADER MOHD ABDUL , BABU A. V. KISHORE , RAO A. SRINIVASA 
Published: June 2020

Objective: To identify frequency, type, severity and predictors of potential drug-drug interactions(pDDIs), potential drug-food interactions(pDFIs), potential drug-alcohol interactions(pDAIs) and potential drug-tobacco interactions(pDTIs) and most frequently interacting drug combination pairs in hospitalized patients from departments(depts) of General Medicine(GM), Orthopedic(Ortho), Gynecology(OBG), Pulmonology(Pulmo), General Surgery (GS), Psychiatry (Psych), Otolaryngology(ENT) and Dermatology (Derm) of study population.
Methods: A Prospective Observational Study was conducted in eight major dept's of a tertiary care teaching hospital for a period of 6 mo. A sample size of 650 prescriptions reflecting admission no's for each department were used.
Results: A total of 650 patients were included in the study. Among them, 282(43.4%) were males and 368(56.6%) were females. The mean age of the study population was 39.67±15.23. A total of 487 pDDIs, 734 pDFIs, 586 pDAIs and 159 pDTIs were found out of 650 hospitalized episodes. OBG showed the highest pDDIs and pDAIs. Highest pDFIs and pDTIs were seen in Pulmo. The majority of DDIs were minor, DFIs and DAIs were moderate and DTIs were of major in severity. Pharmacokinetic types of interactions were seen in the majority of the depts. Logistic regression analysis showed that Polypharmacy was associated with the occurrence of DIs. Most of the DIs repeated several times in particular depts and a list of these combinations was prepared.
Conclusion: With the high occurrence of overall DIs and characteristic patterns of DIs combination pairs among different departments of the hospital, the presence of clinical pharmacists in hospitals can play a great role, especially in developing nations like India where their role in hospitalized settings is always controversial.
Medición del clima organizacional en una Pyme del sector servicios de la región centro de Hidalgo
Authors: Rodríguez Martínez Jocelyn Estrella , Martínez Muñoz Enrique , Duana Avila Danae , Hernández Gracia Tirso Javier 
Published: June 2020

En los últimos años, se han incrementado las Pymes, principalmente las del sector servicios, las cuales ofrecen innumerables oportunidades para estimular el crecimiento y el empleo en un país. Sin embargo, pese a que las Pymes son el pilar fundamental de las organizaciones modernas, en los últimos años se ha frenado su crecimiento debido a la baja productividad que han tenido.
Una de las debilidades de los directivos de las Pymes, es el no considerar a sus empleados como clientes internos, olvidan que ellos reflejan la filosofía, los valores, la calidad y el servicio que brinda la empresa; por lo tanto, dejan de lado el ambiente laboral y los empresarios dan por hecho que les proporcionan a sus empleados las herramientas necesarias para que desarrollen sus funciones y se desempeñen adecuadamente.
En la presente investigación, se plantea el estudio para medir el clima organizacional en una Pyme del sector de servicios del estado de Hidalgo, mediante la aplicación de un cuestionario a sus trabajadores, con la finalidad de conocer la percepción que estos tienen acerca del ambiente que les rodea en la empresa. Una vez procesada la información, se obtuvieron resultados alarmantes, los cuales indicaron que la empresa tiene un clima organizacional con un nivel bajo, esto quiere decir que los empleados carecen de motivación, compromiso y no están satisfechos.
Ante este análisis, sus dirigentes podrían implementar acciones para conducir la gestión de cambios en su clima laboral y logren planificar técnicas que influyan en los trabajadores para que en estos exista un sentimiento de pertenencia que los motive a mejorar su desempeño y con ello, se incremente la productividad, se optimicen los servicios para ser más competitivos y se aseguren la permanencia de la empresa en el mercado.
Attitudes towards technology among distance education students: Validation of an explanatory model
Authors: Romero Martínez Sonia J. , Ordóñez-Camacho Xavier G. , Guillen-Gamez Francisco David , Bravo Agapito Javier 
Published: June 2020

Attitudes towards technology are preconceived notions that have an effect on the teaching-learning process and on the academic-professional performance of students, in particular those who use technology as a means of study. This investigation has two objectives: on the one hand, to test the measuring properties (reliability, factorial structure) of an instrument to measure attitudes and, on the other hand, to propose and validate a model that hypothesizes that digital competence and frequency of use of technologies have a positive impact on same. 1251 students of the Madrid Open University participated. It is a non-experimental, explanatory study using structural equation methodology. The results show adequate psychometric properties for the test and good adjustment of the proposed model (χ²=163.91, df=37, p<.001) allowing for further exploration of the relationship between use, skill and attitudes in the distance education context and improving the properties of measuring instruments proposed in Spanish.
KEMAMPUAN LITERASI SAINS PADA MATERI ZAT MELALUI MODEL PEMBELAJARAN INKUIRI TERBIMBING BERBANTUAN MULTIMEDIA
Authors: Agustina Inai Ria , Andinasari Andinasari , Lia Linda 
Published: June 2020

Penelitian ini bertujuan untuk mengetahui kemampuan literasi sains pada materi zat melalui model inkuiri terbimbing berbatuan multimedia. Sampel penelitian ini adalah siswa kelas VII C dan VII D SMP Negeri 1 Banyuasin II. Penelitian ini dilakukaan menggunakan quasi eksperimental dengan tipe non-quivalent control group design. Data diuji dengan analisis uji normalitas, uji homogenitas, dan uji hipotesis. Berdasarkan hasil analisis data diketahui bahwa kemampuan literasi sains dengan uji hipotesis menunjukkan t-hitung = 3,40 > t-tabel. Maka dapat disimpulkan bahwa H0 diterima sehingga kemampuan literasi sains pada materi zat terdapat pengaruh positif melalui model pembelajaran inkuiri terbimbing berbantuan multimedia di SMP Negeri 1 Banyuasin II.