bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors on admission and condition at discharge of 529 consecutive COVID-19 patients at a tertiary care center in Santiago, Chile
Authors: Maquilon Cesar , Gongora Jonas , Antolini Monica , Alvarado Bernardita , Valdes Nicolas , Benavente Angela , Bofill Maria , Urra Macarena , Rojas Diego , Huidobro Javiera , Asenjo Maria Carolina , Gutierrez Cherie , Gajardo Jose , Cisternas Patricia , García Guillermo , Peralta Juan , Loor Lenny , Sepulveda Anneliese , Tapia Cecilia , Mallea Luis , Rivera Felipe , Parodi Ezio , Nien Jyh 
Published: September 2020

Abstract
Background: The first case of COVID-19 was reported in Chile on March 3, 2020. Public and private hospitals were managed in a centralized manner. On May 30, Chile had 99,668 cases, 1054 deaths, 1383 ICU patients, 1174 patients on invasive mechanical ventilation (IMV), and 51 patients on non-invasive ventilation (NIMV). Research question: What are the variables associated with condition at discharge?Method: We performed a retrospective cohort study of 529 patients with a positive RT-PCR for SARS CoV-2who were consecutively discharged between March 14 and June 4, 2020, at Clínica Dávila, Santiago. Patients were analyzed according to laboratory variables on admission, Quality-Adjusted Life Year (QALY) score, health insurance, and type of respiratory support. Condition at discharge was survivor, non-survivor, or transfer to another center. Differences were evaluated by Chi-square test, Student’s t test, or Mann–Whitney U test. Logistic regression analysis was performed to identify variables that were predictive of condition at discharge.Results: Median (interquartile range, IQR) age was 49 (37–62) years, and the median (IQR) stay in the hospital was 6 (3–10) days. A total of 352 patients (66.5%) had respiratory symptoms, 177 (33.4%) had other symptoms or diagnoses on admission, and 116 required ventilatory support; 448 (84.7%) were survivors, 54 (10.2%) were non-survivors, and 27 (5.1%) were transferred. The median ages of the survivors and non-survivors were 46 (36–59) and 75.5 (66–84), respectively.Having state health insurance increased the risk of death by 2.8-fold (OR, 2.825; 95% CI: 1.383–5.772; P = 0.004). Multivariate analysis revealed the following predictive variables: age ≥ 60 years (OR, 15.3; 95% CI: 7.25–32.2; P = .001); PaO2/FiO2 on admission ≤ 200 vs > 200 (OR, 5,205; CI 95%: 1,942–13,94); high-sensitivity troponin, ≥ 15 vs <15 ng /L (OR, 5,163; 95% CI: 1.95–13,64; P = .001); and QALY ≤ 15 vs > 15 points (OR, 14,011; 95% CI: 4,826–40,679; P=.001).Interpretation: The variables analyzed and patient’s clinical evolution may allow assignment of ICU beds to patients with the greatest chance of survival, especially in countries or regions where this resource is limited.
XII Curso de Verão do Programa da Pós-Graduação em Reabilitação Oral FORP-USP/Edição 2020
Authors: Reis Andréa Cândido dos , Araújo Camila Borba de , Parize Hian Nivaldo , Silva Allan Oliveira da , Lima Ana Emanuela Cisne de , Carvalho Brenda Gonçalves de , Freitas Bruna Neves de , Fortes Caroline Vieira , Goyeneche Daniel Zuluaga , Mendes Filipe Santos Ferreira , Montarele Letícia Ferreira , Sobreiro Michelli Menezes , Campos Murilo Rodrigues de , Santos Neto Otavio Marino dos , Vivanco Rocio Geng , Kreve Simone , Vinha Thaís Costa , Costa Thiago Naves Queiroz , Mata Victor Barboza da , Del Rey Yumi Chokyu 
Published: September 2020

EditorialNo decorrer da história do Programa de Pós Graduação em Odontologia (Reabilitação Oral), o Curso de Verão vem promovendo as pesquisas desenvolvidas no Departamento de Materiais Dentários e Prótese, com o intuito de convidar a comunidade odontológica a fazer parte desse ambiente acadêmico. Sendo assim a comissão organizadora da XII Edição do Curso de Verão do Programa de Pós Graduação em Reabilitação Oral ofereceu aos seus participantes de diversos estados do país e de outros países uma gama de oportunidades dentro da Faculdade de Odontologia de Ribeirão Preto, com a sua grade cientifica voltada para pesquisas laboratoriais e clínicas, das quais diversos docentes da unidade expuseram as suas linhas de pesquisa.Essa edição do curso atingiu proporções inimagináveis, com altos números de inscrições, nunca obtido nas versões anteriores. Além disso o engajamento da comissão organizadora juntamente com a qualidade de material apresentado pelos palestrantes proporcionaram uma experiencia que tem sido avaliada pelos participantes como única e imensurável, concretizando ainda mais a existência do curso dentro do programa e aumentando a abrangência das nossas feitorias para a população.Assim, damos início a série de Anais do Curso de Verão, da qual essa é a segunda edição que possibilitou aos seus participantes apresentarem seus trabalhos, garantindo a troca de experiencias entre as diversas universidades. Além de agradecermos a participação de todos no evento, com muita responsabilidade, dedicação e carinho. Comissão OrganizadoraXII Curso de Verão do Programa de Pós Graduação em Reabilitação OralEdição 2020
Photo-catalytic degradation of polyphenolic tannins in continuous-flow reactor using titanium dioxide immobilized on a cellulosic material
Authors: Jouali Abdelhadi , Salhi Anas , Aguedach Abdelkahhar , Lhadi El Kbir , El Krati Mohammed , Tahiri Soufiane 
Published: September 2020

Abstract
Tannins are recalcitrant polyphenolic molecules that resist microbial attack. Their main environmental damage is due to their low biodegradability. This work aims to investigate the photo-catalytic degradation of two commercial tannin extracts, chestnut (hydrolysable tannin) and mimosa (condensed tannin). The experiments were carried out under UV-light irradiation in a continuous-flow reactor using titanium dioxide (TiO2) immobilized on cellulosic fibers. It was highlighted that photo-catalytic degradation is unfavourable in acidic medium and when the pH is too high (pH above 12); it reaches its maximum efficiency at pH 7.5 (99 and 97% for chestnut and mimosa, respectively). Nearly complete degradation of tannins requires an irradiation period of 6 h. The process efficiency is inversely affected by the concentration of tannins essentially above 75 mg/L for chestnut and 60 mg/L for mimosa. Above 240 mL/min, any increase in feed flow negatively affects the performance of the process. Furthermore, a significant decrease of treatment efficiency was seen when increasing the concentration of ethanol and salts in the medium. Obtained results suggest that UV-light irradiation in a continuous-flow photo-reactor using immobilized TiO2 may be considered as an adequate process for the treatment of water containing recalcitrant tannin molecules.
PLANEJAMENTO AMBIENTAL EM BACIAS HIDROGRÁFICAS SEMIÁRIDAS DO NORDESTE BRASILEIRO
Authors: Lima Ernane Cortez 
Published: September 2020

O planejamento categorização e enquadramento de bacias hidrográficas semiáridas no nordeste brasileiro torna-se imprescindível tendo como escopo assegurar às águas qualidade compatibilizada com os usos mais diversificados a que estas forem destinadas. As pesquisas voltadas para o planejamento e ordenamento territorial através de estudos ambientais integrados no contexto de bacias hidrográficas, podem ser fundamentais para as políticas públicas que visem um melhor uso e ocupação do território, procurando adequar-se ao desenvolvimento sustentável. Desta maneira a Política Nacional de Recursos Hídricos vem sendo aprimorada por meio da legislação dos recursos hídricos através da apoio de órgãos estaduais que estabelecem segurança à política dos mananciais dos estados da federação brasileira.
Palavras-chave: Bacias hidrográficas, planeamento ambiental, semiárido.
Gene Expression Profiling Analysis to Identify Key Genes and Underlying Mechanisms in Meniscus of Osteoarthritis Patients
Authors: Wang Bin , Zhong Jun-Long , Xu Xiang-He , Wu Biao , Shang Jie , Jiang Ning , Lu Hua-Ding 
Published: September 2020

Background:
Osteoarthritis (OA) is a degenerative joint disease that seriously affects
the quality of life of elderly. Regrettably, the pathological mechanism for OA has not yet been fully
elucidated.

Methods:
This study is committed to distinguishing key genes and the underlying mechanisms for
OA. Raw data was acquired from the Gene Expression Omnibus (GEO) database. We identified differentially
expressed genes (DEGs), hub genes, and key genes through bioinformatics analysis.
Subsequently, we predicted the microRNAs (miRNAs) and circular RNAs (circRNAs) associated
with these key genes that may play key roles in OA using web tools. We also constructed a protein-
drug network and found potentially effective drugs by analyzing the relationships between the
drugs and the key genes.

Results:
The analysis revealed 360 DEGs, 24 hub genes, and 15 key genes enriched in many categories
potentially related to the pathological mechanism of OA. hsa-miR-29a-3p, hsa-miR-29b-3p,
and hsa-miR-29c-3p were predicted to be important miRNAs for OA, while hsa_circ_0025119,
hsa_circ_0025113, hsa_circ_0009897, and hsa_circ_0002447 were predicted to be the most important
circRNAs. Further studies indicated that Ocriplasmin and Collagenase clostridium histolyticum
may be effective drugs for the treatment of OA. Finally, CD34 and VWF were inferred to
be the most meaningful biomarkers for OA.

Conclusion:
In conclusion, we determined the underlying key genes, miRNAs, and circRNAs for
OA, predicted potentially effective drugs, and identified the most meaningful biomarkers for the
disease. Our findings may provide insight into the pathological mechanism of OA and guide future
research.
Interpretable SMILES-based QSAR Model of Inhibitory Activity of Sirtuins 1 and 2
Authors: Worachartcheewan Apilak , Toropova Alla P. , Toropov Andrey A. , Pratiwi Reny , Prachayasittikul Virapong , Nantasenamat Chanin 
Published: September 2020

Background:
Sirtuin 1 (Sirt1) and sirtuin 2 (Sirt2) are NAD+
-dependent histone deacetylases which play important functional roles in removal of the acetyl group of acetyl-lysine substrates. Considering the dysregulation of Sirt1 and
Sirt2 as etiological causes of diseases, Sirt1 and Sirt2 are lucrative target proteins for treatment, thus there has been great interest in the development of Sirt1 and Sirt2 inhibitors.

Objective:
This study compiled the bioactivity data of Sirt1 and Sirt2 for the construction of quantitative structure-activity
relationship (QSAR) models in accordance with the OECD principles.

Method:
Simplified molecular input line entry system (SMILES)-based molecular descriptors were used to characterize the
molecular features of inhibitors while the Monte Carlo method of the CORAL software was employed for multivariate analysis. The data set was subjected to 3 random splits in which each split separated the data into 4 subsets consisting of training, invisible training, calibration and external sets.

Results:
Statistical indices for the evaluation of QSAR models suggested good statistical quality for models of Sirt1 and
Sirt2 inhibitors. Furthermore, mechanistic interpretation of molecular substructures that are responsible for modulating the
bioactivity (i.e. promoters of increase or decrease of bioactivity) was extracted via the analysis of correlation weights. It exhibited molecular features involved Sirt1 and Sirt2 inhibitors.

Conclusion:
It is anticipated that QSAR models presented herein can be useful as guidelines in the rational design of potential Sirt1 and Sirt2 inhibitors for the treatment of Sirtuin-related diseases.
Molecular Docking Studies of Bioactive Nicotiflorin against 6W63 Novel Coronavirus 2019 (COVID-19)
Authors: Dubey Raghvendra , Dubey Kushagra 
Published: August 2020

Background::
COVID-19 which is known as the novel coronavirus was reported in December
2019 in Wuhan city, China and many people have been contaminated by environmental
contamination and transmission from one human to another until now.

Objective::
The objective of the present work is to establish the inhibitory potential of nicotiflorin, a
Kaempferol 3-O-rutinoside flavonoid, against the deadly coronavirus (COVID-19) 6W63 (main
protease 3Clpro protein), using molecular docking approach.

Method::
The Molegro Virtual Docker software (MVD) with a 30 Å grid resolution was used. The structure was drawn by
Chem 3D software and energy minimization was done by the MM2 force field. The protein 6W63 was downloaded from the
protein data bank. Molegro modeller was used for score calculations.

Result::
The molecular docking studies were carried out on nicotiflorin and standard inhibitor X77, where standard inhibitor
was observed in a co-crystallized state with main protease 3Clpro protein 6W63. The MolDock score, Rerank Sore and H
Bond score of nicotiflorin and standard inhibitor X77 was observed as -173.058, -127.302, -21.9398 and -156.913,-
121.296,-5.7369, respectively.

Conclusion::
Molecular docking studies have confirmed that the affinity of flavonoid nicotiflorin with the amino acids of the
viral protein 6W63 was relatively more than the standard X77. For the effective treatment of novel coronavirus COVID-19,
the effectiveness of the identified flavonoid nicotiflorin can further be evaluated for safety and efficacy parameters at both
preclinical and clinical stages.
Biologic Therapy and Treatment Options in Diabetic Retinopathy with Diabetic Macular Edema
Authors: Nissen Tobias P. H. , Vorum Henrik , Aasbjerg Kristian 
Published: September 2020

Abstract:Proliferative diabetic retinopathy and diabetic macular edema can be a potentially sightthreatening disease if not treated correctly. It is directly correlated to the duration of diabetes and how well managed the patients' diabetes is. In the last 15 years, the treatment of diabetic eye disease has taken a quantum leap in methodology due to the group of biological agents named antivascular endothelial growth factor (anti-VEGF). The introduction of the first biological agent has revolutionized the treatment, not only in diabetic eye disease but also across most inflammatory eye diseases, causing leakage of fluid from the blood vessels i.e., in age-related macular degeneration. The availability of these biological agents, despite their considerable costs, have significantly improved the outcomes measured in visual acuity compared to more traditional treatments of diabetic retinopathy in the form of sole laser treatment and glycemic control. The agents demonstrate a favorable safety profile, but if the rarest and most severe side effects occur, there is a potential total loss of vision.This review aims to make an overview of the current pharmaceutical therapeutic options in the treatment of diabetic macular edema. This includes laser therapy, intravitreal steroids, and a primary focus on intravitreal antivascular endothelial growth factors.
Evidences of Brain Plasticity and Motor Control Modulation after Hemodialysis Session by Helixone Membrane: BOLD-fMRI Study
Authors: Boujraf Saïd , Belaïch Rachida , Housni Abdelkhalek , Alami Badreeddine , Skalli Tariq , Maaroufi Mustapha , Tizniti Siham 
Published: September 2020

Objective:
The aim of this paper is to demonstrate the impact of hemodialysis (HD) using
synthetic Helixone membrane on brain functional control reorganization and plasticity in the cortical
area generated while Oxidative Stress (OS) would be the main impacting agent.

Methods:
Indeed, 9 chronic HD patients underwent identical brain BOLD-fMRI assessment using the
motor paradigm immediately before and after the same HD sessions. To assess the oxidative stress, the
same patients underwent biological-assessment, including Malondialdehyde (MDA) and Total-
Antioxidant-Activity (TAOA) reported in earlier papers.

Results:
BOLD-fMRI maps of motor areas obtained from HD-patients before and after HD sessions
revealed a significant enhancement of activation volume of the studied motor cortex after HD reflecting
brain plasticity. Results were correlated with OS assessed by the measurement of MDA and
TAOA; this correlation was close to 1.

Conclusion:
Indeed, HD enhances the inflammatory state of brain tissues reflected by the increased
OS. The functional brain reaction demonstrated a functional activity reorganization to overcome the
inflammatory state and OS enhanced by HD process. This functional activity reorganization reveals
brain plasticity induced by OS originated by HD.
Performance and egg qualities of old-laying hens fed with diets containing selected phytogenic feed additives
Authors: Ayeni A. O. , Oladedun A. E. , Agbede J. O. 
Published: September 2020

Performance and egg qualities of old-laying hens fed with diets containing ginger, turmeric and garlic were evaluated in a twelve (12) week feeding trial. A total of 135 laying birds of Isa-Brown strain which were sixty-four (64) weeks old were used for the trial and arranged in a completely randomized design. Five diets were formulated for the trial: Diet 1 (control), Diet 2 (3% inclusion level of turmeric), Diet 3 (3% inclusion level of ginger), Diet 4 (turmeric and garlic at 2.25% and 0.75%, respectively) and Diet 5 (ginger and garlic at 2.25% and 0.75%, respectively). Proximate compositions of the Phytogenic Feed Additives (PFAs) were determined with the moisture content ranging between 5.03-7.50%; ash (3.26-6.11%); ether extract (7.39-14.58%); fibre (10.28-13.79%); protein (3.07-7.23%) and Nitrogen Free Extract (58.88-61.54%). The performance indices, though not significantly (P˃0.05) influenced by the test diets except for Hen Day Production (HDP) had the highest weight gained (0.16kg) recorded for birds fed on a diet containing ginger. The highest (62.92 and 62.04 %) HDP were observed in birds fed diets containing ginger and ginger + garlic; respectively. However, the lowest weight gained (0.04kg) was recorded in birds fed a diet containing turmeric + garlic; this diet also recorded the lowest % HDP and FCR with values of 57.50% and 2.37 respectively. The overall values for the qualities of eggs from laying hens fed the PFAs showed that only the Haugh Unit, yolk colour and albumen height were significantly (P˂0.05) affected; with those on Turmeric + Garlic diets having the highest for these parameters. However, the fatty acid variables were not significantly (P˃0.05) affected by the dietary treatments. It could be concluded that the inclusion of PFAs in the diets of laying hens especially at an older age would help to sustain performance with improved quality.
Giant juvenile ossifying fibroma from diagnosis to management: A rare case
Authors: Mokhtar Ejaz Ahmad , Verma Sumit , Alam Shamshad , Fatima Qalbi 
Published: September 2020

Juvenile aggressive ossifying fibroma is a rare, benign tumor of the maxillofacial region that is aggressive and recurrent leading to multiple surgeries causing maxillofacial defect and deformities. The management of patients with ossifying fibroma is controversial. The aim was to report a case of huge ossifying fibroma involving maxilla, zygoma, and orbit in a young female with a duration of 15 years. The patient was operated multiple times but the lesion recurred. Patient-specific implant was fabricated to replace the defect area which would be created after surgery but with meticulous intraoperative decision the high morbid surgery was changed to conservative surgery. No recurrence was seen after two year follow up. The patient aesthetic has also improved. In conclusion it can be said in huge benign ossifying fibroma morbid surgery should be avoided.
Hydraulic efficiency of irrigation channels in the course of operation
Authors: Kosichenko Yurij M. , Baev Oleg A. 
Published: August 2020

Introduction. The co-authors have analyzed different reasons for the reduction of the hydraulic efficiency of irrigation channels comprising hydro-technical reclamation systems. The main factors include plant invasion, siltation and deformation of beds. The co-authors provide data describing changes in the values of bed roughness ratios and efficiency of main and distributary channels in the process of operation in the south of Russia.
Materials and methods. The hydraulic efficiency of irrigation and drainage systems will be called the pro-vision of their high throughput, close to the design, with minimal losses. They are based on throughput capacity and efficiency values, acceptable flow rates and water losses due to the process of filtration. The criteria have been developed in furtherance of the analysis of operation of irrigation channels and previous studies.
Results. Factors reducing throughput capacity and channel efficiency have been identified for normal operating conditions; dependences needed to identify other hydraulic efficiency factors are also provided. Based on the analysis of actual data, the efficiency of main canals in the earthen bed is 0,790, and for canals in the cladding — 0,870, which is significantly lower than the re-quirements of the norms. Computer assisted processing of the field data on roughness and channel efficiency ratios, obtained under normal conditions, was performed to obtain empirical dependences n = f(Q) and η = f(Q). The field data describing changes in the throughput capacity of linings and earth beds of irrigation channels exposed to significant plant invasions (vegetation and algae) are provided for comparison purposes. The influence of these factors is demonstrated in the photos and proven by the values of roughness ratios that are two to four times different from the design ones.
Conclusions. Comparison of the roughness coefficients for 15 canals and sections with strong overgrowth with the design data indicates that for canals in the earthen channel their roughness increases by 2.5...4.0 times, and for canals in the lining — 1.7...2.5 times. Weedy bed roughness ratios were obtained by applying theoretical formulas and the field data, their comparison has demonstrated close convergence in respect of three channels, including Nizhne-Donskoy and Azovsky main channels, as well as distributary channel Bg-R-7.