bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of a pediatric long‐term Home Ventilation Program in Argentina: 11 years' experience
Authors: Leske Vivian , Guerdile María J. , Gonzalez Adriana , Testoni Fernanda , Aguerre Verónica 
Published: January 2020

AbstractBackgroundPediatric home ventilation (HV) has increased worldwide. A Home Ventilation Program (HVP) was started in the Pulmonary Department of the “Hospital de Pediatría Prof. Dr. J. P. Garrahan,” Argentina, in 2007. This is the largest Argentine national pediatric tertiary care referral center. Limited studies on pediatric HV from Latin American countries have been published.ObjectiveThis study describes and analyzes the cohort of children admitted to the HVP during an 11 years period.MethodsLongitudinal study. Population: all patients (pts) admitted to the HVP between 2007 and 2018. We analyzed demographic and clinical variables, sleep study results, ventilation setting, and start manner collected in a prospective data base.ResultsA total of 244 pts were admitted. Median age at ventilation start was 9.41 (3.47‐14.08) years, 84% of pts had health insurance. The most frequent underlying diseases were neuromuscular disease (43%) and genetic syndromes (23%). Home‐hospital distance was 100‐500 km in 16% of cases and greater than 500 km in 34%. Seventy percent of pts had sleep studies before ventilation initiation. Ventilation was started in our general pediatric ward in 83.6%. Noninvasive ventilation was used in 86.1%. The actual number of pts still on follow up is 133 of 244 (54.5%), 16.8% dropped out, 16.4% were transitioned to adult care, 5.32% resolved their sleep‐disordered breathing, and 5.32% died.ConclusionsThe HVP admitted pts from all the country. Ventilation was started on the basis of clinical and objective sleep measures. This long‐term experience underlines the feasibility of a HVP in an emergent country.
Shock Initiation Microscopy with High Time and Space Resolution
Authors: Bassett Will P. , Johnson Belinda P. , Salvati Lawrence , Nissen Erin J. , Bhowmick Mithun , Dlott Dana D. 
Published: January 2020

AbstractWe describe studies of shock initiation and shock‐to‐detonation transitions in energetic materials using a tabletop shock compression microscope with nanosecond time resolution and micrometer spatial resolution. Planar input shocks with durations of 4–20 ns are produced using 0–4.5 km/s laser‐launched flyer plates. Emphasis is on measurements of temperature, velocities, pressure, and microstructure using photon Doppler velocimetry (PDV), optical pyrometry and high‐speed videography. Techniques are discussed for fabricating disposable shock target arrays of tiny plastic‐bonded explosives (PBX), liquid and powder explosives, and single‐crystal explosives for high‐throughput studies. Optical temperature measurements of shocked triaminotrinitrobenzene (TATB) are discussed. Since TATB is yellow, we developed methods to correct for the blue absorption to obtain more accurate temperatures. Hot spots in shocked polymer‐encased HMX (octahydro‐1,3,5,7‐tetranitro‐1,3,5,7‐tetrazocine) crystals are observed in real‐time, showing a hot spot produced in a collapsing void that ignites a deflagration. Despite the small dimensions of our explosive charges (typically 1 mm diameter and 250 μm length), we produced reproducible detonation states in solid and liquid explosives using short‐duration shocks near the von Neumann spike (VNS) pressure. We show the VNS pressure is associated with a transition to high‐efficiency gas production from the explosives. In studies of NM, prior to detonation, we see reaction originating at hot spots which coalesce to form a superdetonation.
Predicted impacts of proposed hydroelectric facilities on fish migration routes upstream from the Pantanal wetland (Brazil)
Authors: Medinas de Campos Marcel , Tritico Hans M. , Girard Pierre , Zeilhofer Peter , Hamilton Stephen K. , Fantin‐Cruz Ibraim 
Published: January 2020

AbstractThere are 104 hydroelectric facilities proposed to be installed in the watersheds that feed the Pantanal, a vast floodplain wetland located mostly in Brazil. The Pantanal is host to 23 long‐distance migratory fish species that ascend upland tributaries to spawn. A Geographic Information System was used to predict the impact of hydroelectric dams on potential migration routes for these species. Both anthropogenic (hydroelectric dams) and natural barriers were included in the analysis. Natural barriers were identified by river slope. Critical river slopes of 10 and 25%, above which fish were predicted to be incapable of ascending, were modeled as natural barriers. Based on this model, we show that between 2 and 14% of rivers in the Pantanal watershed are naturally blocked to fish migration. An additional 5 to 9% of rivers are currently blocked due to 35 existing hydroelectric facilities. If all proposed dams are built, the area flooded by new reservoirs will triple and the river kilometers blocked will double, blocking 25 to 32% of the river system to fish migration. The Taquari and Cuiabá River sub‐basins will be the most impacted, each having more than 70% of their rivers blocked. The impact of individual proposed facilities on the loss of migration routes is related to their proximity to existing barriers. Fourteen of the proposed dams are upstream from existing barriers and will therefore not further restrict long‐distance fish migration routes while proposed dams are predicted to close an additional 11,000 to 12,000 km of river channels.
Isopropyl Cresols: Synthesis and Herbicidal Activity
Authors: Wang Jing , Dong Huanhuan , Zhang Hongmei , Dai Songlin , Jiang Jianxin , Zhao Zhendong 
Published: January 2020

AbstractIsopropyl cresols were prepared by a two‐step process: monoterpene oxidation catalyzed by CrO3 and terpenone isomerization catalyzed by 13X molecular sieves. 5‐Isopropyl‐3‐methylphenol and carvacrol were prepared from 3‐carene, whereas thymol and 4‐isopropyl‐3‐methylphenol were synthesized from α‐pinene. The two reactions followed an identical procedure, but the reaction of 3‐carene was more efficient, benefiting from the three‐membered ring in the structure. 5‐Isopropyl‐3‐methylphenol, thymol, and carvacrol were found to show higher herbicidal activity than glyphosate toward the root growth of barnyard grass. However, they exhibited slightly lower activity in preventing shoot growth. Moreover, 5‐isopropyl‐3‐methylphenol showed higher herbicidal activity than its isomers, which indicates that the relative position of substitutes is significantly associated with the herbicidal activity of isopropyl cresols.
Identification of Potential Inhibitors from Traditional Chinese Medicine for Fibroblast Growth Factor Receptor 1 Based on Virtual Screening and Molecular Dynamics Analysis
Authors: Sun Peng , Jiang Chen , Zhou GuiFen , Zhang Qiao Yan , Cheng Gang , Qin LuPing 
Published: January 2020

AbstractFibroblast growth factor receptor 1 (FGFR1) is involved in the process of cell proliferation, differentiation and function, especially in bone skeletal development. It is a potential new therapeutic target for osteoporosis and other skeletal‐related diseases. In this study, we aim to identify FGFR1 inhibitors from Traditional Chinese Medicine (TCM) database by the structure‐based virtual screening and MM/GBSA scoring. First, 26450 compounds were filtered by Lipinski rules of five, followed by a hierarchy virtual screen workflow which includes glide docking, ranking, cluster analysis and visual inspection to afford 40 potential compound candidates. Finally, 6 candidates were selected based on MM/GBSA binding energy analysis of the with FGFR1 protein. Our modelling study would provide some clues to the discovery of novel FGFR1 inhibitors as potential therapeutic drugs for osteoporosis. In addition, given multipotency characteristic of FGFR1, these potential inhibitors might provide some reference to other related diseases, such as non‐small cell lung cancer and squamous cell lung cancer.
Predicting Hadoop misconfigurations using machine learning
Authors: Robert Andrew , Gupta Apaar , Shenoy Vinayak , Sitaram Dinkar , Kalambur Subramaniam 
Published: January 2020

SummaryDistributed applications are popular for heavy workloads where the resources of a single machine are not sufficient. These distributed applications come with many parameters to tune so that cluster resources can be effectively utilized. However, any misconfiguration of the available parameters may result in suboptimal performance of one or more machines in the cluster. These events may go unnoticed or can result in crashes. This problem of misconfigured parameters has no straightforward solution due to the variety of parameters and vastly different workloads being processed. In this article, we propose a methodology for machine learning‐based detection of misconfigurations. We collect data mined from system resource utilization, Hadoop logs, and job‐level metrics to train a model using decision tree and support vector machine. The models are used to identify whether a set of configuration parameters could result in a crash or a slowdown for a specific workload. The approach explained in this article can be extended to other distributed big data applications, such as Spark, Hive, Pig, and so on.
Discovery of two novel and adjacent QTLs on chromosome B02 controlling resistance against bacterial wilt in peanut variety Zhonghua 6
Authors: Luo Huaiyong , Pandey Manish K. , Zhi Ye , Zhang Huan , Xu Siliang , Guo Jianbin , Wu Bei , Chen Haiwen , Ren Xiaoping , Zhou Xiaojing , Chen Yuning , Chen Weigang , Huang Li , Liu Nian , Sudini Hari K. , Varshney Rajeev K. , Lei Yong , Liao Boshou , Jiang Huifang 
Published: January 2020

Abstract
Key message
Two novel and adjacent genomics and candidate genes for bacterial wilt resistance were identified on chromosome B02 in peanut variety Zhonghua 6 using both traditional QTL mapping and QTL-seq methods.

Abstract
Peanut (Arachis hypogaea) is an important oilseed crop worldwide. Utilization of genetic resistance is the most economic and effective approach to control bacterial wilt, one of the most devastating plant diseases, in peanut production. To accelerate the genetic improvement of bacterial wilt resistance (BWR) in peanut breeding programs, quantitative trait locus (QTL) mapping has been conducted for two resistant varieties. In this context, we deployed linkage mapping as well as sequencing-based mapping approach, QTL-seq, to identify genomic regions and candidate genes for BWR in another highly resistant variety Zhonghua 6. The recombination inbred line population (268 progenies) from the cross Xuhua 13 × Zhonghua 6 was used in BWR evaluation across five environments. QTL mapping using both SSR- and SNP-based genetic maps identified a stable QTL (qBWRB02-1) on chromosome B02 with 37.79–78.86% phenotypic variation explained (PVE) across five environments. The QTL-seq facilitated further dissection of qBWRB02-1 into two adjacent genomic regions, qBWRB02-1-1 (2.81–4.24 Mb) and qBWRB02-1-2 (6.54–8.75 Mb). Mapping of newly developed Kompetitive allele-specific PCR (KASP) markers on the genetic map confirmed their stable expressions across five environments. The effects of qBWRB02-1-1 (49.43–68.86% PVE) were much higher than qBWRB02-1-2 (3.96–6.48% PVE) and other previously reported QTLs. Nineteen putative candidate genes affected by 49 non-synonymous SNPs were identified for qBWRB02-1-1, and ten of them were predicted to code for disease resistance proteins. The major and stable QTL qBWRB02-1-1 and validated KASP markers could be deployed in genomics-assisted breeding (GAB) to develop improved peanut varieties with enhanced BWR.
Tandem peptide receptor radionuclide therapy using 90Y/177Lu-DOTATATE for neuroendocrine tumors efficacy and side-effects - polish multicenter experience
Authors: Kunikowska Jolanta , Zemczak Anna , Kołodziej Maciej , Gut Paweł , Łoń Izabela , Pawlak Dariusz , Mikołajczak Renata , Kamiński Grzegorz , Ruchała Marek , Kos-Kudła Beata , Królicki Leszek 
Published: January 2020

Abstract
Introduction
One of the concepts of theranostics in nuclear medicine is peptide receptor radionuclide therapy (PRRT), whereby labeled somatostatin analogs are used for imaging and treating inoperable or disseminated neuroendocrine tumors (NET).

Aim
The aim of the study was to determine the therapeutic efficacy and toxicity of tandem 90Y /177Lu-DOTATATE in patients with disseminated NET in a multicenter trial.

Materials and methods
103 patients with NET G1/G2 treated with 90Y/177Lu-DOTATATE (1:1) with amino-acid infusion for nephroprotection were included in the study.

Results
Overall survival from the disease diagnosis (OS-D) was 127.4 months and from the time of PRRT (OS-T) was 89.5 months. Progression-free survival (PFS) was 29.9 months. An analysis based on the proliferation index revealed a statistically significant impact on PFS and OS-T (PFS G1 vs G2, 59.3 vs 24.3 months; OS-T G1 vs G2, not reached vs 79.9 months). The effect of the primary disease site was also analyzed. For pancreatic vs small bowel vs large bowel, the PFS was 30.8 vs 30.3 vs 40.6 months, the OS-T was 94 vs 61.9 vs 131.2 months and OS-D was 130.4 vs 89.2 vs not reached months, respectively. The 2-year risk of progression was 42%. The probability of 2-year and 5-year overall survival was 89% and 62%, respectively. PRRT was well tolerated by all patients. One patient (1%) developed myelodysplastic syndrome. No other grade 3 and 4 hematological or renal toxicity was observed.

Conclusions
This multicenter trial showed that tandem 90Y/177Lu-DOTATATE is highly effective and safe therapy for patients with disseminated NET.
Incidence, diagnostics and treatment algorithm of nerve lesions after traumatic shoulder dislocations: a retrospective multicenter study
Authors: Tiefenboeck T. M. , Zeilinger J. , Komjati M. , Fialka C. , Boesmueller S. 
Published: January 2020

Abstract
Background
The shoulder is the joint most prone to dislocating in the human body and accounts for 45% of all dislocations. In addition to ruptures of the soft tissue and bony injuries, lesions to vascular structures as well as the brachial plexus and its corresponding nerves might occur. With an incidence of up to 65%, nerve lesions are frequently reported after shoulder dislocations. The aim of this study is to obtain information on epidemiology, diagnostics, treatment and duration until remission or late sequelae after shoulder dislocation and concomitant nerve injury in a large patient cohort.

Methods
The patient cohort consisted of 15,739 patients from three centres who had sustained a shoulder dislocation. All patient files were searched for concomitant injury of the brachial plexus or its corresponding nerves. For epidemiological data analysis, demographic data, clinical follow-ups, electromyography and nerve conduction velocity were evaluated.

Results
In total, 60 patients (32 males, 28 females) with a mean age of 60 years (range 19–88 years) met the inclusion criteria. In the majority of patients (n = 51), the trauma mechanism was a trivial fall on the outstretched arm. The most frequent dislocation direction was anterior-caudal in 61.6%, followed by strictly caudal in 16.6%. The brachial plexus was injured in 46 patients (76.6%) and isolated nerve damage was documented in 14 patients (23.3%). Electroneurographic examinations were performed in less than half of the patients (38.3%).

Conclusion
A combination injury of shoulder dislocation and plexus lesion may occur at any age and sometimes has a poor outcome. Electroneurographic examinations should be implemented when managing these patients as a cost-effective and supportive examination.

Level of evidence
Level IV, retrospective study.
An increased bone mineral density is an adverse prognostic factor in patients with systemic mastocytosis
Authors: Riffel Philipp , Schwaab Juliana , Lutz Christopher , Naumann Nicole , Metzgeroth Georgia , Fabarius Alice , Schoenberg Stefan O. , Hofmann Wolf-Karsten , Valent Peter , Reiter Andreas , Jawhar Mohamad 
Published: January 2020

Abstract
Purpose
Systemic mastocytosis (SM) is characterized by the expansion of clonal mast cells that infiltrate various organ systems. The extent of organ infiltration and subsequent organ damage distinguishes between indolent SM (ISM) defined by a nearly normal life expectancy and advanced SM (AdvSM) defined by poor prognosis. In ISM, measurement of the bone mineral density (BMD) frequently reveals osteoporosis. In contrast, the clinical implication of an increased BMD and osteosclerosis remains unclear.

Methods
BMD was evaluated in 61 patients with mastocytosis (ISM, n = 29, 48%; AdvSM, n = 32, 52%). We correlated the prevalence of osteoporosis, increased BMD and osteosclerosis with clinical parameters, disease variant and prognosis.

Results
Osteoporosis was detected in 11/29 (38%) patients with ISM but only in 2/32 (6%) patients with AdvSM (p = 0.004). An increased BMD was detected in 1/29 (3%) patients with ISM and 24/32 (75%) patients with AdvSM (p < 0.001) while osteosclerosis was only detected in AdvSM patients (16/32, 50%). AdvSM patients with increased BMD had higher levels of bone marrow mast cell infiltration, higher serum tryptase and alkaline phosphatase levels compared to ISM as well as higher number of high-molecular risk mutations (p < 0.05). In addition, we found that the prognosis of AdvSM patients with increased BMD is inferior compared to those without increased BMD (median overall survival 3.6 years versus not reached, p = 0.031).

Conclusions
Osteoporosis is a common feature in ISM but not in AdvSM. An increased BMD is frequently present in AdvSM but not in ISM and is associated with more advanced disease and inferior outcome.
Lung function is associated with minimal EQ-5D changes over time in patients with systemic sclerosis
Authors: Ciaffi Jacopo , van Leeuwen Nina M. , Liem Sophie I.E. , Ninaber Maarten K. , Huizinga Tom W.J. , de Vries-Bouwstra Jeska K. 
Published: January 2020

AbstractIn systemic sclerosis (SSc) therapeutic efforts are often directed to prevent progressive respiratory impairment, but it is unclear to what extent changes in pulmonary function tests (PFTs) are associated with health-related quality of life (HRQoL). The aim of our study is to evaluate how modifications in PFTs contribute to longitudinal variations in HRQoL, assessed through the multidimensional questionnaire EQ-5D, in patients with SSc. We included SSc patients with forced vital capacity (FVC%), diffusing capacity of the lungs for carbon monoxide (DLCO%) and EQ-5D assessed in at least two visits. The EQ-5D consists of two parts, a utility score ranging from − 0.59 to 1, and a 0–100 Visual Analogue Scale (VAS). Higher values represent better health. The association between changes in FVC% and DLCO%, and evolution of EQ-5D over time, was investigated using generalized estimating equations. Three hundred seventy-eight patients were included, accounting for a total of 1619 measurements. The models showed that improvement in FVC% is significantly associated with increase in both utility score (β = 0.001; 95% CI 0.000 to 0.002; p = 0.003) and VAS over time (β = 0.188; 95% CI 0.111 to 0.264; p < 0.001). Moreover, improvement in DLCO% is longitudinally associated with increase in utility score (β = 0.001; 95% CI 0.000 to 0.002; p = 0.038), while the results for VAS were non-significant (β = 0.020; 95% CI -0.079 to 0.120; p = 0.690). We show that change in PFTs has a significant, although minor, impact on HRQoL as measured by EQ-5D in SSc.Key Points• In patients with SSc, changes in PFTs have a significant, although minor, impact on HRQoL.• In patients with SSc-ILD, the perception of HRQoL is nearly not influenced by changes in pulmonary function.• The use of generic questionnaires might not be sensitive enough to evaluate the impact on quality of life of therapies targeting specific SSc manifestations.
Japan society of clinical oncology/Japanese society of medical oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors, cooperated by the Japanese society of pediatric hematology/oncology
Authors: Naito Yoichi , Mishima Saori , Akagi Kiwamu , Igarashi Ataru , Ikeda Masafumi , Okano Susumu , Kato Shunsuke , Takano Tadao , Tsuchihara Katsuya , Terashima Keita , Nishihara Hiroshi , Nishiyama Hiroyki , Hiyama Eiso , Hirasawa Akira , Hosoi Hajime , Maeda Osamu , Yatabe Yasushi , Okamoto Wataru , Ono Shigeru , Kajiyama Hiroaki , Nagashima Fumio , Hatanaka Yutaka , Miyachi Mitsuru , Kodera Yasuhiro , Yoshino Takayuki , Taniguchi Hiroya 
Published: January 2020

Abstract
Background
The development of novel antitumor agents and accompanying biomarkers has improved survival across several tumor types. Previously, we published provisional clinical opinion for the diagnosis and use of immunotherapy in patients with deficient DNA mismatch repair tumors. Recently, efficacy of tropomyosin receptor kinase inhibitors against neurotrophic receptor tyrosine kinase (NTRK) fusion gene-positive advanced solid tumors have been established as the second tumor-agnostic treatment, making it necessary to develop the guideline prioritized for these patients.

Methods
Clinical questions regarding medical care were formulated for patients with NTRK-positive advanced solid tumors. Relevant publications were searched by PubMed and Cochrane Database. Critical publications and conference reports were added manually. Systematic reviews were performed for each clinical question for the purpose of developing clinical recommendations. The committee members identified by Japan Society of Clinical Oncology (JSCO) and Japanese Society of Medical Oncology (JSMO) voted to determine the level of each recommendation considering the strength of evidence, expected risks and benefits to patients, and other related factors. Thereafter, a peer review by experts nominated from JSCO, JSMO, and Japanese Society of Pediatric Hematology/Oncology, and the public comments among all Societies’ members was done.

Results
The current guideline describes 3 clinical questions and 15 recommendations for whom, when, and how NTRK fusion should be tested, and what is recommended for patients with NTRK fusion-positive advanced solid tumors.

Conclusion
In the NTRK guideline, the committee proposed 15 recommendations for performing NTRK testing properly to select patients who are likely to benefit from tropomyosin receptor kinase inhibitors.