bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of gene polymorphism of certain cytokines on echocardiographic parameters in patients with chronic rheumatic heart disease
Authors: Petrov V. S. 
Published: November 2019

Aim.To assess the effect of polymorphism of tumor necrosis factor-а (TNF-α) cytokines and interleukin (IL-17A, IL-17F, IL-10) on echocardiographic parameters in patients with chronic rheumatic heart disease (RHD).Material and methods. A total of 128 patients with RHD were examined, average age was 58,96±0,34 years. Echocardiography was performed on a Philips Affinity 50 machine. Genotyping was carried out using polymorphic TNF-α markers (G308A, IL-10 G1082A, IL-17A G197A, IL-17F А161Н0 by polymerase chain reaction with an electrophoretic scheme for detecting the result of “SNP-EXPRESS”.Results. RHD homozygotes for TNF-а A308A had the largest linear dimensions of the left ventricle (left ventricle end-diastolic dimension (LVED) — 5,80±0,22 cm, left ventricle end-systolic dimension (LVES) — 3,93±0,27 cm), as well as the studied homozygous for IL-17A A197A (LVED — 5,81±0,13 cm, LVES — 3,78±0,11 cm). In group of TNF-α G308G homozygotes, values of right heart (right ventricle — 2,75±0,05 cm, right atrium — 4,80±0,11 cm) were the largest and mitral valve orifice area (MVOA) was smallest — 1,52±0,04 cm2. Heterozygous patients with IL-17F Д161Н also had a greater dilatation of the ventricles compared with homozygotes of IL-17F Н161Н, in which parameters were close to normal (LVED 5,58±0,05 cm, LVES 3,68±0,04 cm). There was no statistically significant difference in linear sizes of the left and right heart in patients with IL-10 polymorphism. IL-10 polymorphism patients had statistically significant MVOA differences: minimum MVOA in G1082A heterozygotes — 1,40±0,06 cm2and maximum — 1,64±0,04 cm2in G1082G homozygotes. IL-10 G1082G homozygotes was characterized by maximum values of interventricular septum — 1,13±0,04 cm, left ventricular posterior wall — 1,10±0,03 cm.Conclusion. Homozygosity of TNF-α A308A and IL-17A A197A in RHD patients leads to the largest linear sizes of the left ventricle, and homozygosity for TNF-а G308G — to the maximum sizes of the right heart and left atrium against the background of the minimum sizes of MVOA. IL-10 polymorphism has not effect on heart linear dimensions, but IL-10 G1082G leads to maximum MVOA size.
Polymorphic variants of genes encoding Ca(2+)-transporting sarcoplasmic reticulum proteins in the progression of chronic heart failure
Authors: Muslimova E. F. , Rebrova T. Yu. , Archakov E. A. , Akhmedov Sh. D. , Budnikova O. V. , Batalov R. E. , Afanasiev S. A. 
Published: November 2019

Aim. To study the association between polymorphic rs1860561 variants of Ca(2+)-ATPase SERCA2a (ATP2A2) gene and rs3766871 of ryanodine receptor (RYR2) gene and the severity of chronic heart failure (CHF).Material and methods. We determined rs1860561 and rs3766871 variants of the ATP2A2 and RYR2 genes, respectively, in 168 patients with coronary artery disease (CAD) and CHF using real-time polymerase chain reaction.Results. A statistically significant (p=0,046) decrease in the left ventricular ejection fraction in AA homozygotes of the ATP2A2 gene compared to carriers of the G allele was shown. But among GG homozygotes, patients with FC II CHF prevailed and participants with FC I CHF were less common than among patients with genotype GA (p=0,041).Conclusion. The association of the AA genotype carriage for the rs1860561 variant of the ATP2A2 gene encoding Ca(2+)-ATPase SERCA2a, with a decrease in the left ventricle ejection fraction in patients with CHF and CAD was revealed. At the same time, among the GG homozygotes, FC I CHF was the least prevalent. There was no association of the rY3766871 variant of the RYR2 gene with CHF severity.
Polymorphic variant rs1739843 of heat shock protein beta-7 (HSPB7) gene and its relationship with on clinical profile and outcomes in patients with hypertrophic cardiomyopathy (results of a 10-year follow-up)
Authors: Streltsova A. A. , Gudkova A. Y. , Poliakova A. A. , Pyko S. A. , Kostareva A. A. 
Published: November 2019

Aim. To determine the impact of polymorphic variant rs1739843 of the HSPB7 gene on clinical profile and outcomes in patients with hypertrophic cardiomyopathy (HCM).Material and methods. The study population consisted of 108 patients with HCM ≥45 years old. The control group included 192 healthy donors. The design of the study included an assessment of the clinical course, determining the outcome of HCM using a new methodological approach proposed by Rowin EJ, et al. (2017). Polymorphic variant rs1739843 of the HSPB7 gene was genotyped by allele-specific real-time polymerase chain reaction (PCR) assay.Results. It was found a significant increase in frequency of TT genotype of rs1739843 of the HSPB7 gene in patients with HCM — 20,4%, compared with control group — 4,2% (ТТ: ТС+СС, odds ratio (OR) =5,88, 95% confidence interval (CI) =2,52-13,75, p<0,001). High prevalence of CC genotype of rs1739843 of the HSPB7 gene was observed in control group — 80,2% vs 31,5% in HCM group (CC: ТС+TT, OR=0,11, 95% CI=0,07-0,19, p<0,001). The allele frequency (С:Т) also differs between HCM and control groups — 55,6:44,4% in HCM vs 88,02:11,98% in control group (OR=5,88, 95% CI=3,91-8,85, p<0,001). It was also found a significant increase in frequency of TT genotype and T allele of rs1739843 of the HSPB7 gene in HCM patients with oligosymptomatic HCM course — 16,7%, compared with control group — 4,2% (ТТ: ТС+СС, OR=4,60, 95% CI=1,63-12,99, p<0,001). HCM patients ≥45 years old showed a significant increase in T allele frequency in cases of presence of 2 (FC III-IV CHF (chronic heart failure)+AF (atrial fibrillation), 18,8% vs 6,6%) and 3 adverse pathways (FC III-IV CHF+AF+SCD (sudden cardiac death), 4,2% vs 1,6%).Conclusion. HCM progression along 2 and more adverse pathways in patients ≥45 years old has been characterized with adverse outcome. The T allele and TT genotype of rs1739843 of the HSPB7 gene were more frequent in patients with HCM ≥45 years old, compared with control group. It was also found a significant increase in frequency of TT genotype and T allele of rs1739843 of the HSPB7 gene in HCM patients with oligosymptomatic HCM course, compared with control group.Allele T of rs1739843 of the HSPB7 gene is associated with 2 and more adverse pathways of HCM progression.
Study of effectiveness and reliability of education on ergonomic risk factors and musculoskeletal complaints in patient-carrier personnel of Shahid Bahonar Hospital of Kerman
Authors: Eskandari nasab N , Mirmohammadi SJ , Mehrparvar AH , Fallah H 
Published: November 2019

Introduction: Lack of awareness of the principles and rules of ergonomics, inappropriate postures and frequent displacement of patients and loads can cause musculoskeletal disorders in medical personnel. The purpose of this study was to evaluate the effectiveness of in-person training and social network education on the ergonomic risk factors and musculoskeletal of patient carrier personnel in the Shahid Bahonar Hospital of Kerman.
Method: This study is an applied and quasi-experimental study. That was performed on 60 participants in Shahid Bahonar Hospital kerman. The participants were randomly divided into two groups of 30. The first group was trained via in-person training method combined with practical work and questionings and the second group was trained via social networks. The data were collected through a self-made questionnaire measuring awareness, Nordic questionnaire along with the scale of the investment rate and the numerical checklist patient transfer assessment index (PTAI) was collected before training for one week, one month and six months after training. For analyzing the data, SPSS software version 24 was used.
Results: Low back pain is more prevalent among sick carriers than other musculoskeletal disorders. There was a significant difference between the knowledge and PTAI scores in both methods before and six months after training (P <0.05). Also, comparing neck (P = 0.014), shoulder (P = 0.006), waist (P = 0.00), knee (P = 0.006), and foot (P = 0.016) complaints in training method There was a significant difference before and six months after training. There was no significant difference in musculoskeletal complaints at the end of six months in education via social media.
Conclusion: According to the results, it seems that both in-person and via social media training had an impact on reducing ergonomic risk factors and musculoskeletal complaints. And the effect of in-person training was significantly greater than that of via social media training. In addition, the reliability of the training effect was significant only In-person training
THE TERROR OF THE PERIOD OF THE FIRST RUSSIAN REVOLUTION IN THE ASSESSMENT OF BRITISH DIPLOMATS (ON THE MATERIALS OF THE BRITISH NATIONAL ARCHIVE)
Authors: Aleksandrovna Portnyagina Natalia , Igorevich Portnyagin Dmitry 
Published: November 2019

Purpose of the study: To explore in detail the terror of the period of the first Russian revolution in the assessment of British diplomats during the revolution of 1905-1907.
Methodology: The research is based on archival documents, most of which are introduced into scientific discourse for the first time, as well as periodical press materials of that time. The research draws from the documents of the British National Archive and the Russian State Historical Archive (fund: 1276 - Office of the Council of Ministers). The article employs chronological, historical-typological, historical-genetic, comparative and illustrative research methods, as well as systematic analysis and synthesis.
Main Findings: The research suggests that in 1905-1907 terror affected not only Russian but also British citizens. British reaction to terror in Russia slowed down the signing of a foreign policy agreement between the countries.
Applications of this study: The study may be used by historians and everyone interested in the questions of the First Russian Revolution as well as the history of diplomatic relations with Britain. The results of the study can be used in universities to study the history of Russia and the history of international relations at the beginning of the 20th century.
Novelty/Originality of this study: Many historians focus on terror in Russia during the revolution of 1905-1907. However, the reflections on revolutionary terror by British diplomats did not become a subject of research in Russian or foreign historiography.
CONSTITUTIONAL EXPERIMENT: REGULATORY APPROACHES IN FRANCE AND SPAIN
Authors: V. Markhgeym Marina , G. Zagaynova Goar , N. Gutorova Alla , N. Nifanov Aleksej , E. Tonkov Evgeniy 
Published: November 2019

Purpose: The article is devoted to the study of the constitutional experiment features in France and Spain. The author analyzes the regulations, including the constitutions and laws of both France and Spain. It also provides the analysis of constitutional regulation methods in these countries.
Methodology: The methodological basis of the study was the set of scientific knowledge leading methods. The methods of analysis and synthesis are widely used among general scientific ones, formal legal and comparative legal methods are among private scientific ones.
Result: The analysis of approaches to the formalization of the constitutional-legal experiment on the example of two European countries - France and Spain - showed the difference in corresponding models and levels. France developed the system of the state constitutional legal experiment regulation at the level of the Constitution and other legal acts (organic law, regulations, etc.), taking into account the corrective law-enforcement practice of constitutional control body - the Constitutional Council. The implementation of constitutional legal experiments in France was associated with the decentralization of power, the activities of public scientific and cultural institutions, criminal justice, social policy, etc.
Applications: This research can be used for universities, teachers, and students.
Novelty/Originality: In this research, the model of Constitutional Experiment: Regulatory Approaches in France and Spain is presented in a comprehensive and complete manner.
Mara’s rising from total submissiveness to absolute emancipation in Beyond The Horizon by Amma Darko
Authors: ALLAMAGBO René-Kinée , HOUNDJO Docteur Théophile 
Published: November 2019

Marital life has usually been almost unbearable for women in African fiction. During the last decades, their status has been changing very fast. In Beyond the Horizon by AmmaDarko, Mara, after having undergone maltreatment, carelessness and domination from her husband Akobi in Africa as well as in Europe, has ended up sending him to prison. This article attempts to explore how somefemale characters are endowed with the necessary courage to report the ill-treatment they have undergone to the right person or authority in order to take a revenge and have things changed for themselves. As pointed out by the study, Marahas proved that change must originate from her not from anybody else.
In order to be able to closely explore how Mara, as the embodiment of empowered women in the contemporary African fiction has improved (herself), it has been thoroughly evidenced such aspects as naivety, illiteracy and most importantly economic dependence of the female characters as the main factors working in an adverse way against them both in fiction and society.
Living Conditions of Sub-Saharan Immigrants in Belgium: A Socio-Economic Approach of Eating Habits
Authors: Ségbé Dr BALLE Guy-Romaric 
Published: November 2019

The objective of this study is to understand the socio-economic relationships in habits among sub-Saharan immigrants in Belgium. The interactions between the new living environment and pre-immigration habits were also a focus of the study. The quantitative survey was carried out in seven Belgian cities on a sample of 180 persons. The qualitative part consisted of interviews with twelve sub-Saharan immigrants. The results showed that the main factors explaining the consumption of African food are: the presence of a spouse in the household, children's interest in African products, household size and the availability (supply) of products from the country of origin. Moreover, it appears that the length of stay on Belgian territory does not significantly affect the consumption of African products. Relationships to African food are variously perceived and expressed by sub-Saharan Africans. Basically, their consumption seems to respond to a need to reinvent the socio-emotional microcosm necessary to preserve sacred links with the land of origin. However, in this new and constraining environment, the economic and financial condition of these immigrants does not represent a major factor in the decision-making process for purchasing exotic products.
The Political Symbolism in George Orwell Writings: With Reference to “Animal Farm” and “Nineteen Eighty Four”
Authors: Albloly Amir Mohammed , Nour Dr. Hala Salih Mohammed 
Published: November 2019

This research article aims to mirror the political symbolism and its significance in George Orwell writings with reference to “Animal Farm” and “Nineteen Eighty Four”. It is an attempt to depict the political ideologies of Orwell’s writings in the abovementioned novels, his message and legitimate fears and warning for future generations against the scandals of totalitarianism and finally to uncover the distortion of power when spoiled by ill-mannered politicians as symbolized by room 101 in “1984” and manifested in the seven commandments prescribed by old major and later amended by Napoleon. In their pursuit to achieve the main objectives of this article, the researchers utilized a blend of approaches to find out clear-cut, evident and tangible justifications beyond Orwell’s use of “political symbolism” in both novels. That is, by virtue of adopting the analytical and critical discourse analysis methodologies along with the novels’ books of “Animal Farm” and “Nineteen Ninety Four” as the primary source of data and collected reviews offered by other writers as the secondary source of data; it could be concluded that for Orwell the political symbolism was not only a sword and shield for protection against totalitarian regimes but also was a platform for liberty and freedom of express when democracy is completely absorbed by such dictators and totalitarian governments.
Uji Aktivitas Antioksidan Ekstrak n-Heksana, Etil Asetat, Metanol Daun dan Akar Bakau Merah (Rhyzophora stylosa) dengan Metode DPPH
Authors: Hanapi Ahmad , Fasya Ahmad Ghanaim , Syakuro Abdan 
Published: November 2019

<p>Red mangrove (<em>Rhizophora stylosa</em>) is one of the mangrove species which is abundance in the coast of Java. The mangrove contains a lot of active compounds that is potent as antioxidant. The objective of this study was to determine antioxidant activity of n-hexane, ethyl acetate, and methanol extract of red mangrove leaves and roots using DPPH (1,1-diphenyl-2-picrylhydrazyl) method. Active compound extraction of red mangrove is conducted by gradual maceration. According to phytochemical analysis, crude root extract showed the presence of flavonoids, tannins, and steroids/triterpenoids, while crude leave extract showed the presence of alkaloids, flavonoids, tannins, saponins, and steroids/triterpenoids. EC<sub>50</sub> value of methanol extract from red mangrove leaves and roots was 5.01 and 2.55 ppm, respectively, whilst of ethyl acetate extracts from red mangrove leaves and roots was 89.94 and 8.51 ppm, respectively. Crude extract n-hexane has antioxidant activity 33.14 ppm (EC<sub>50</sub>). Roots and leaves extracts have high activity of antioxidant.</p><p> </p><p>Keywords: Antioxidant, red mangrove, DPPH method</p><p> </p><p> </p><p>Bakau merah (<em>Rhizophora stylosa</em>) merupakan salah satu spesies bakau yang keberadaannya sangat melimpah di pesisir pantai Pulau Jawa dan mengandung banyak senyawa aktif yang berpotensi sebagai antioksidan. Penelitian ini bertujuan untuk mengetahui aktifitas antioksidan ekstrak n-heksana, etil-asetat, metanol pada akar dan daun bakau merah menggunakan metode DPPH. Ekstraksi senyawa aktif pada akar dan daun dilakukan dengan metode maserasi bertingkat menggunakan n-heksana, etil asetat dan metanol. Ekstrak kasar dilakukan uji fitokimia dan aktivitas antioksidannya menggunakan metode DPPH (<em>1,1-difenil-2-pikrilhidrazil</em>). Hasil pengujian fitokimia dari ekstrak kasar akar menunjukkan adanya senyawa flavonoid, tanin, dan steroid/triterpenoid, sedangkan ekstrak kasar daun menunjukkan adanya alkaloid, flavonoid, tanin, saponin, dan steroid/triterpenoid. Nilai EC<sub>50</sub> (<em>Efficient Concentration</em>) ekstrak metanol daun dan akar berturut-turut sebesar 5,01 dan 2,55 ppm, sedangkan ekstrak etil-asetat daun dan akar berturut-turut sebesar 89,94 dan 8,51 ppm. Adapun ekstrak n-heksana daun menghasilkan nilai EC<sub>50</sub> sebesar 33,14 ppm. Ekstrak akar dan daun bakau merah memiliki aktivitas antioksidan yang tinggi.</p><p><strong> </strong></p><p>Kata kunci: Antioksidan, bakau merah, metode DPPH</p>
PERAN KEMENTERIAN AGAMA KOTA MALANG DALAM MEMBINA KELUARGA MUALLAF
Authors: Syuhadak Faridatus , Farkhanudin M. 
Published: November 2019

<p>Tujuan penelitian ini adalah untuk mengetahui bagaimana kondisi keluarga muallaf dibawah binaan kementerian agama kota malang, dan untuk medeskripsikan bagaimana model pembinaan keluarga muallaf oleh kementerian agama kota malang. Penelitian ini adalah penelitian empiris. Yang diolah secara kualitatif dengan pendekatan studi kasus. Data primer dalam penelitian ini diperoleh dari wawancara dengan keluarga muallaf di Kota Malang. Data sekundernya diperoleh dari wawancara dengan pembina dari Kementerian Agama Kota Malang dan diperkuat dengan beberapa literatur. Analisis data bersifat deskriptif yang menggambarkan keaadan keluarga muallaf dan model pembinaanya. Hasil dari penelitian ini yaitu, Pertama latar belakang masuk islam dari setiap keluarga muallaf dibawah binaan Kementerian Agama Kota Malang itu berbeda beda. banyak dari mereka yang masuk Islam sebab mengikuti agama suami dan panggilan hati. Akhirnya tekanan mental, dan ekonomi dari keluarga sebelumnya adalah keniscayaan bagi para muallaf. Hal ini menjadi problem lanjutan dalam membangun keluarga sakinah. Para keluarga muallaf sudah kuat secara aqidah, mereka sudah bisa sholat dan mengaji. Namun tidak di imbangi dengan ekonomi yang baik. Kedua, model pembinaan muallaf oleh kementerian agama kota malang sudah berjalan dengan baik dengan model ceramah dan penguatan aqidah, namun follow up nya terkait membangun keluarga sakinah dan penguatan ekonomi belum berjalan dengan baik.</p><p> Kata kunci: Pembinaan; Keluarga Sakinah; Muallaf</p>
ANALISIS KETIMPANGAN PEMBANGUNAN EKONOMI DAN KETIMPANGAN DISTRIBUSI PENDAPATAN DI PROVINSI KALIMANTAN SELATAN (STUDI KASUS KOTA BANJARMASIN DAN KABUPATEN TANAH BUMBU)
Authors: Suntari Martin Vegarika , Yunani Ahmad 
Published: November 2019

Abstract - This study aims to find out how the level of economic development inequality and the inequality of income distribution in Banjarmasin City and Tanah Bumbu Regency, and how the comparison of the economic development inequality and the inequality of income distribution in that two regions. This study uses secondary data from the period of 2013-2017. The data is obtained from BPS. The analysis of inequality level of economic development using Williamson index, and analyzing the inequality of income distribution using the index gini ratio. The comparison results of Williamson index and the gini ratio index during 2013-2017 found that each analysis tool had different results. So that, it can be explained that the inequality level of regional economic development in the Tanah Bumbu Regency area with an average of 0.171 occurred due to the economy which relies on natural resources (mining and excavation), the mobility of goods and services is not smooth (distribution of goods and migration). However, the level of inequality in income distribution is low with an average of 0.312. It is because the depreciation of people's work is not much different, so that the income distribution is more evenly distributed. The inequality of economic development in Banjarmasin city is low with an average of 0.021. It occurs because the Banjarmasin city is the center of economy activities in the Province of South Kalimantan (the provincial capital). Banjarmasin city has the better infrastructure availability than other regions. In contrary, the inequality level of income distribution is in high level with an average of 0.354. It occurs because of the differences in types of work and skills of people in Banjarmasin. In addition, it also occurs becauce Banjarmasin City has a small area so that there is an inequality in income distribution.

Keywords: Williamson Index, and Gini Ratio Index.
Admission pattern, Clinical outcome and associated factors among patients admitted in medical intensive care unit at University of Gondar Comprehensive and Specialized Hospital, Northwest Ethiopia, 2019. A retrospective cross-sectional study.
Authors: Tesema Hailemariam Getachew , Lema Girmay Fitiwi , Mesfin Nebiyu , Fentie Demeke Yilkal , Arefayne Nurhussien Rizike 
Published: November 2019

Abstract
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