bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of previous shoulder pain on supraspinatus tendon thickness changes following swimming practice
Authors: Porter Kirsten N. , Blanch Peter D. , Walker Helen M. , Shield Anthony J. 
Published: April 2020

ObjectivesTo assess if swimming practice results in changes in supraspinatus tendon thickness, acromiohumeral distance, and occupational ratio in shoulders of elite swimmers with and without a history of shoulder pain.DesignCase‐Control study.MethodsA convenience sample of fifty elite swimmers (14‐22 years) were recruited for this study. Groups were defined by the presence (history of pain, N = 37) or absence (pain free, N = 63) of significant interfering shoulder pain within the previous 6 months. The current study analyzed supraspinatus tendon thickness, acromiohumeral distance, and the occupational ratio, through the use of ultrasound. Measures were taken prior to swim practice; immediately after practice; and 6 hours post‐practice.ResultsNo statistically significant difference in supraspinatus tendon thickness, acromiohumeral distance or ratio between shoulders with and without a history of pain were found at rest. Following a swimming practice, both shoulders with and without a history of pain had a significant increase in tendon thickness (0.27 & 0.17 mm; P ≤ .001 & <.001). The increase in thickness was significantly greater in the history of pain shoulders compared to pain‐free shoulders (P = .003). At 6‐hour post‐practice, the history of pain shoulders was still significantly thicker than their pre‐practice (rested) levels (P = .007). Despite changes in tendon thickness, the occupational ratio remained non‐significant between groups.ConclusionShoulders with a history of pain show an altered response to swimming practice. The results of the current study have implications for training load and injury management. It should prompt investigation into how the tendon reacts under varying load conditions.
The importance of uninterrupted albendazole treatment in patients with unresectable alveolar echinococcosis undergoing liver transplantation
Authors: Zavoikin Valerij D. , Zelya Olga P. , Tumolskaya Nelli I. 
Published: April 2020

AbstractBackgroundThis study focused on the monitoring of patients who had undergone liver transplantation (LT) because of unresectable alveolar echinococcosis (AE). The role of long‐term administration of albendazole (ABZ) in patients with residual/recurrent AE lesions and without AE lesions was evaluated.MethodsAlbendazole therapy was prescribed to patients diagnosed with AE 4‐6 weeks after LT on the background of continuous suppressive therapy while following the protocol for managing patients after LT. Clinical data (general condition, blood counts, and level of hepatic transaminases), ultrasound scans (USs), magnetic resonance imaging (MRI) or multispiral computed tomography (MSCT), and serological data were collected from four patients with residual/recurrent AE lesions and without AE lesions. The results of the USs, MRI, and MSCT examinations at diagnosis and at the end of follow‐up were retrospectively reviewed for all patients.ResultsObservation of patients over a long period (up to 10 years) showed that the continuous (without interruption) use of ABZ restrained the development of metacestodes. Interruptions in taking the drug, associated with the manifestation of hepatotoxicity in some patients, led to the development of lesions in other organs in which the parasite had not previously been detected. No new foci were found in the transplanted livers of the patients.ConclusionLiver transplantation, together with continuous anti‐relapse chemotherapy, prolongs the patient's life, both in the absence and in the presence of metastases in other organs.
Mothers and fathers improve immature baboon foraging success
Authors: Lynch Emily C. , Johnson Caley A. , Lynch Robert F. , Rothman Jessica M. , Di Fiore Anthony , Palombit Ryne A. 
Published: April 2020

Abstract
For many animal species, immatures are less efficient foragers than their adult counterparts and must use multiple strategies to fulfill their nutritional needs through effective learning of social and feeding behaviour. To overcome these challenges, young animals are predicted to rely on adult relatives to gain foraging competency, partly because kin are more likely to tolerate the proximity of immatures, upon which socially facilitated learning of food selection and foraging skills depends. While evidence suggests that mothers improve the foraging success of their offspring, little is known about the potential contribution of fathers to the development of feeding skills. Here, we investigate the influence of both mothers and fathers on the foraging behaviour of young olive baboons (Papio anubis) in Laikipia, Kenya. Behavioural data were gathered via focal animal sampling and genetic relatedness was determined by microsatellite genotyping of non-invasively collected faecal DNA samples. We also conducted analyses to assess the nutritional and energetic content of staple foods consumed by the baboons. We found that, compared to when feeding near unrelated adults or alone, immatures were more likely to consume high energy foods when they were near their mothers and preliminary results suggest access to similar effects when near fathers. These data advance well-documented maternal influences on the foraging competence of offspring in a matrilocal society, and additionally suggest the importance (and possible long-term fitness benefits) of associations between offspring and their fathers.
Fashioning the Materiality of the Pilgrimage: The ḥajj Travelogue of Muḥammad Labīb al-Batanūnī
Authors: Kateman Ammeke 
Published: April 2020

Abstract
In 1911, the Egyptian travel writer Muḥammad Labīb al-Batanūnī published a highly informative account of his pilgrimage journey, al-Riḥla al-Ḥijāziyya. This article is interested in al-Batanūnī’s representation (or fashioning) of the ḥajj and its materiality, as it reflects the conventions of his time and with which the author simultaneously hopes to shape the interpretations and practices of his contemporaries. Specifically, the article focuses on the way al-Batanūnī represents the objects and matters of the ḥajj (for example, Zemzem water) in opposition to interpretations and practices of his contemporaries within, as well as beyond, Islam.
Khomeini and Muḥammad al-Shīrāzī: Revisiting the Origins of the “Guardianship of the Jurisconsult” (wilāyat al-faqīh)
Authors: Scharbrodt Oliver 
Published: April 2020

Abstract
This article revisits the origins of Khomeini’s concept of the guardianship of the jurisconsult (wilāyat al-faqīh) and argues that his own formulation of this concept needs to be embedded in debates around the clerical mandate in the state among clerical activists in Iraq he encountered during his exile. Focus will be on the so-called Shīrāzī network around the brothers Muḥammad (1928-2001), Ḥasan (1927-80) and Ṣādiq al-Shīrāzī (b. 1942) and their nephew Muḥammad Taqī al-Mudarrisī (b. 1945) The article discusses the close relationship between Khomeini and Muḥammad al-Shīrāzī and the important role the religio-political networks associated with the Shīrāzī brothers played in early post-revolutionary Iran. A detailed discussion of the writings of the Shīrāzī brothers and Taqī al-Mudarrisī, written between 1960 and 1970, is undertaken to illustrate that debates around wilāyat al-faqīh among Iraqi clerical activists preceded Khomeini’s own lectures on the concept in Najaf in 1970.
Nāzik al-Malāʾikah and Edgar Allan Poe: Their Poetry and Related Poetics
Authors: Khaldi Boutheina 
Published: April 2020

Abstract
This study argues that Nāzik al-Malāʾikah’s poetics—as indicated in her “Introduction” to her collection Shaẓāyā wa-ramād and her book Qaḍāyā al-shiʿr al-muʿāṣir—is in conversation with the famous American poet, critic, and short story writer Edgar Allan Poe’s poetics. This affinity has not been properly noted by critics, as their discussions have been limited to issues of form, content, or borrowings from Poe’s poems. This article argues that al-Malāʾikah’s elaborations on Poe are more profound than hitherto assumed since they articulate a different kind of formal poetics altogether. The chief characteristics of this poetics can be identified as sound/rhythm, concision, refrain (or repetition, with variation). While these innovative instances are foundational in her literary criticism, her poetry also conveys other venues of indebtedness and conversation.
“Zahra’s Uncle, or Where Are Men in Women’s War Stories?”
Authors: Hartman Michelle 
Published: April 2020

Abstract
Scholarship in modern Arabic literary studies has treated the literature of the Lebanese Civil War, particularly novels written by women, in some depth. One of the most important texts used in both scholarship and teaching about this war is Ḥanān al-Shaykh’s Ḥikāyat Zahrah, translated as The Story of Zahra. This article focuses specifically on the one chapter in the novel narrated from the point of view of the protagonist’s uncle in order to explore how the English translation dramatically changes a number of elements in the original text. It uses insights from translation studies to show how significant changes to the novel in translation produce a text that serves particular ideological functions in English, consistent with a horizon of expectations that constructs Arab women as oppressed and passive victims of war. The article analyzes specific translation choices—most notably the extensive editing out of words, sentences, and passages—to demonstrate how the character of Zahrah’s uncle is changed in English and depicted as an unsavory and abusive man with little background, context, or history that would help the reader to better understand the character’s actions and motivations. It also shows how cutting out elements of the uncle’s story serves to depoliticize the text in English, divesting it of its local political context and changing its meaning and function as a novel about the Lebanese Civil War. The article is grounded in postcolonial, feminist translation studies, especially those dealing with Arabic fiction, to argue that the English-language novel The Story of Zahra functions within an ideological field that recycles stereotypes and tropes about Arab women. It will propose that the translation changes here depict Arab men against Arab women, rather than in relation to them, and subordinate the analysis of politics and communal relations to a more individual and individualized story of one exceptional woman.
Tamoxifen-induced acute mania: A case report
Authors: Duman Berker , Kuşman Adnan , Çolak Burçin , Şenler Filiz Çay , Kumbasar Hakan 
Published: April 2020

Introduction Tamoxifen is widely used for the treatment of hormone-responsive breast cancer, osteoporosis, and post-menopausal symptoms. Also, tamoxifen is currently under investigation for its anti-manic properties. In this article, we report a case who developed manic episode following the initiation of tamoxifen and remitted with discontinuation of the medication. Case Report A 58-year-old woman was diagnosed with breast cancer. Pathologic diagnosis was invasive ductal carcinoma. Following bilateral total mastectomy operation, trastuzumab was initiated with intervals of 21 days. Five days before the fourth application of trastuzumab, tamoxifen was added. On the sixth day following the initiation of tamoxifen, manic symptoms were developed and she was diagnosed as acute mania. Management and Outcome The oncology department suggested withdrawing tamoxifen due to a possible association between tamoxifen initiation and behavioral symptoms. Manic symptoms were rapidly (approximately 24 h) improved following cessation of tamoxifen. Psychiatric evaluation on the fifth day following cessation of tamoxifen revealed no manic symptoms. An aromatase inhibitor-exemestane was initiated and she showed no side effects with this medication since then. Discussion To our knowledge, this is the first case report of probable tamoxifen-induced mania. Our case report at least indicates that there were possibly some patients who were sensitive to the tamoxifen’s nervous system effects, mainly to manic effects. In conclusion, clinicians should be aware of these rare behavioral adverse effects of tamoxifen.
Selection On synonymous Mutations Revealed by 1135 Genomes of Arabidopsis thaliana
Authors: Wei Lai 
Published: April 2020

Synonymous mutations do not change the amino acid but do change the synonymous codon usage. In genomes of different organisms, the gene conversion process is biased toward GC, which is irrespective of mutation bias. In the coding region, this trend is especially obvious and it is possibly caused by the preference on G/C-ending codons over the A/T-ending ones. If the G/C-ending codons are advantageous, then the synonymous mutations that change A/T to G/C would be “optimal” compared to the opposite ones. In theory, one should observe signals of positive selection on these optimal synonymous mutations. The recently released single-nucleotide polymorphism (SNP) data from the 1001 genome project of Arabidopsis thaliana provided researchers with an unprecedented opportunity to verify this assumption. I fully take advantage of the SNP data from 1,135 A thaliana lines and came to the conclusion that synonymous mutations in natural populations are not strictly neutral: the synonymous mutations that increase GC content (from A/T to G/C) tend to have higher derived allele frequencies (DAFs) and, therefore, are likely to be positively selected. My current study broadens our knowledge of the selection patterns of synonymous mutations and should be appealing to evolutionary biologists. One sentence summary: In 1135 genomes of Arabidopsis thaliana, the synonymous mutations that increase the GC content tend to have higher derived allele frequencies (DAFs) and are likely to be positively selected.
Non-genetic risk factors for atrial fibrillation are equally important in both young and old age: A nationwide population-based study
Authors: Kim Yun Gi , Han Kyung-Do , Choi Jong-Il , Choi Yun Young , Choi Ha Young , Boo Ki Yung , Kim Do Young , Lee Kwang-No , Shim Jaemin , Kim Jin-Seok , Park Yong Gyu , Kim Young-Hoon 
Published: April 2020

Abstract

Aims
There are several non-genetic risk factors for new-onset atrial fibrillation, including age, sex, obesity, hypertension, diabetes, and alcohol consumption. However, whether these non-genetic risk factors have equal significance among different age groups is not known. We performed a nationwide population-based analysis to compare the clinical significance of non-genetic risk factors for new-onset atrial fibrillation in various age groups.

Methods and results
A total of 9,797,409 people without a prior diagnosis of atrial fibrillation who underwent a national health check-up in 2009 were included. During 80,130,090 person-years of follow-up, a total of 196,136 people were diagnosed with new-onset atrial fibrillation. The impact of non-genetic risk factors on new-onset atrial fibrillation was examined in different age groups. Obesity, male sex, heavy alcohol consumption, smoking, hypertension, diabetes and chronic kidney disease were associated with an increased risk of new-onset atrial fibrillation. With minor variations, these risk factors were consistently associated with the risk of new-onset atrial fibrillation among various age groups. Using these risk factors, we created a scoring system to predict future risk of new-onset atrial fibrillation in different age groups. In receiver operating characteristic curve analysis, the predictive value of these risk factors ranged between 0.556 and 0.603, and no significant trends were observed.

Conclusions
Non-genetic risk factors for new-onset atrial fibrillation may have a similar impact on different age groups. Except for sex, these non-genetic risk factors can be modifiable. Therefore, efforts to control non-genetic risk factors might have relevance for both the young and old.
Discordant responses of plasma low-density lipoprotein cholesterol and lipoprotein(a) to alirocumab: A pooled analysis from 10 ODYSSEY Phase 3 studies
Authors: Mahmood Tahir , Minnier Jessica , Ito Matthew K , Li Qian H , Koren Andrew , Kam Ivy W , Fazio Sergio , Shapiro Michael D 
Published: April 2020

AbstractAimsProprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors consistently reduce low-density lipoprotein cholesterol (LDL-C) by 50–60% and lipoprotein(a) (Lp(a)) by 20–30%, but the mechanism of Lp(a) lowering remains unclear. If Lp(a) is cleared by the LDL receptor, similar to LDL-C, then one would expect PCSK9 inhibition to induce a concordant LDL-C/Lp(a) response in an approximately 2:1 ratio. We aim to determine the prevalence of discordant plasma LDL-C/Lp(a) response to the PCSK9 inhibitor alirocumab.MethodsThis is a post hoc, pooled analysis of 10 randomized controlled trials from the ODYSSEY Phase 3 clinical trial program for alirocumab. Patients enrolled in the trials were high cardiovascular risk and/or with heterozygous familial hypercholesterolemia. The primary end point was prevalence of discordant LDL-C/Lp(a) response to alirocumab at 24 weeks. Discordant response was defined as LDL-C reduction &gt;35% and Lp(a) reduction ≤10%, or LDL-C reduction ≤35% and Lp(a) reduction &gt;10%.ResultsOf the 1709 patients in the pooled study cohort, 62.4% were male, and the mean age was 59.2 (SD: 11.0) years. Baseline mean LDL-C was 126.5 (SD: 46.3) mg/dL and baseline median Lp(a) was 46.9 (interquartile range: 21.8-89.0) mg/dL. Total prevalence of discordant LDL-C/Lp(a) response was 21.5% (12.6% with LDL-C &gt;35% reduction and Lp(a) ≤10% reduction; 8.9% with LDL-C ≤35% reduction and Lp(a) &gt;10% reduction). Baseline Lp(a) and familial hypercholesterolemia status did not affect discordance.ConclusionA high prevalence of discordant LDL-C/Lp(a) response was observed with alirocumab, further suggesting that PCSK9 inhibitor therapy with alirocumab reduces plasma Lp(a) through alternative pathways to LDL receptor clearance.
Caco-2 Cells for Measuring Intestinal Cholesterol Transport - Possibilities and Limitations
Authors: Hiebl Verena , Schachner Daniel , Ladurner Angela , Heiss Elke H. , Stangl Herbert , Dirsch Verena M. 
Published: April 2020

Abstract
Background
The human Caco-2 cell line is a common in vitro model of the intestinal epithelial barrier. As the intestine is a major interface in cholesterol turnover and represents a non-biliary pathway for cholesterol excretion, Caco-2 cells are also a valuable model for studying cholesterol homeostasis, including cholesterol uptake and efflux. Currently available protocols are, however, either sketchy or not consistent among different laboratories. Our aim was therefore to generate a collection of optimized protocols, considering the different approaches of the different laboratories and to highlight possibilities and limitations of measuring cholesterol transport with this cell line.

Results
We developed comprehensive and quality-controlled protocols for the cultivation of Caco-2 cells on filter inserts in a single tight monolayer. A cholesterol uptake as well as a cholesterol efflux assay is described in detail, including suitable positive controls. We further show that Caco-2 cells can be efficiently transfected for luciferase reporter gene assays in order to determine nuclear receptor activation, main transcriptional regulators of cholesterol transporters (ABCA1, ABCB1, ABCG5/8, NPC1L1). Detection of protein and mRNA levels of cholesterol transporters in cells grown on filter inserts can pose challenges for which we highlight essential steps and alternative approaches for consideration. A protocol for viability assays with cells differentiated on filter inserts is provided for the first time.

Conclusions
The Caco-2 cell line is widely used in the scientific community as model for the intestinal epithelium, although with highly divergent protocols. The herein provided information and protocols can be a common basis for researchers intending to use Caco-2 cells in the context of cellular cholesterol homeostasis.
A prospective cohort study of MTHFR C677T gene polymorphism and its influence on the therapeutic effect of homocysteine in stroke patients with hyperhomocysteinemia
Authors: Du Xiaoxia , Xiao Lin , Sun Rong , Li Kunpeng , Liang Lin , Song Luping , Liu Zhizhong 
Published: April 2020

Abstract
Background
Hyperhomocysteinemia (HHCY) is a risk factor for cardiovascular and cerebrovascular diseases. The C677T 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism increases homocysteine (HCY) levels. This study analyzed the relationship between C677T MTHFR polymorphism and the therapeutic effect of lowering HCY in stroke patients with HHCY.

Methods
Baseline data were collected from stroke patients with HHCY for this prospective cohort study. The C677T MTHFR genotype was detected by polymerase chain reaction-restriction fragment length polymorphism and the therapeutic effect to reduce HCY was compared.

Results
Of 200 stroke patients 162 (81.0%) completed follow-up and were evaluated. Most of them responded well to treatment (103 cases, 63.5%), but 59 (36.4%) patients were in the poor efficacy group. There was a significant difference in terms of age (P < 0.001), hypertension (P = 0.041), hyperuricemia (P = 0.042), HCY after treatment (P < 0.001), and MTHFR genotype (P < 0.001) between the poor efficacy and effective groups, with increased frequency of the TT genotype in the poor efficacy group. Logistic regression showed that the T allele was associated with poor efficacy (OR = 0.733, 95%CI: 0.693, 0.862, P < 0.001). In the codominant model the TT genotype was associated with poor outcome (OR = 0.862, 95%CI: 0.767, 0.970, P = 0.017) and this was also the case in the recessive model (OR = 0.585, 95%CI: 0.462, 0.741, P < 0.001) but there was no association between CT and TT in the dominant model.

Conclusions
The T allele and TT genotype of the MTHFR C677T polymorphism was associated with poor HCY reduction treatment efficacy in stroke patients with HHCY.

Trial registration
The registration number of the clinical trial is ChiCTR1800020048. Registration date: December 12, 2018.