bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the 1-year decline in midbrain-to-pons ratio in the differential diagnosis of PSP and IPD
Authors: Kannenberg Silja , Caspers Julian , Dinkelbach Lars , Moldovan Alexia-S. , Ferrea Stefano , Südmeyer Martin , Butz Markus , Schnitzler Alfons , Hartmann Christian J. 
Published: December 2020

Abstract
Background
A reliable measure of PSP-specific midbrain atrophy, the midbrain-to-pons ratio (MTPR) has been reported to support the differential diagnosis of progressive supranuclear palsy (PSP) from idiopathic Parkinson’s disease (IPD). Since longitudinal analyses are lacking so far, the present study aimed to evaluate the diagnostic value of the relative change of MTPR (relΔt_MTPR) over a 1-year period in patients with PSP, IPD, and healthy controls (HC).

Methods
Midsagittal individual MRIs of patients with PSP (n = 15), IPD (n = 15), and healthy controls (HC; n = 15) were assessed and the MTPR at baseline and after 1 year were defined. The diagnostic accuracy of the MTPR and its relative change were evaluated using ROC curve analyses.

Results
PSP-patients had a significantly lower MTPR at baseline (M = 0.45 ± 0.06), compared to both non-PSP groups (F (2, 41) = 62.82, p < 0.001), with an overall predictive accuracy of 95.6% for an MTPR ≤ 0.54. PSP-patients also presented a significantly stronger 1-year decline in MTPR compared to IPD (p < 0.001). Though predictive accuracy of relΔt_MTPR for PSP (M = − 4.74% ± 4.48) from IPD (M =  + 1.29 ± 3.77) was good (76.6%), ROC analysis did not reveal a significant improvement of diagnostic accuracy by combining the MTPR and relΔt_MTPR (p = 0.670). Still, specificity for PSP increased, though not significantly (p = 0.500).

Conclusion
The present results indicate that the relΔt_MTPR is a potentially useful tool to support the differential diagnosis of PSP from IPD. For its relative 1-year change, still, more evaluation is needed.
Experimental evaluation of precision and accuracy of RSA in the lumbar spine
Authors: Keller Marie Christina , Hurschler Christof , Schwarze Michael 
Published: December 2020

Abstract
Purpose
Roentgen stereophotogrammetric analysis is a technique to make accurate assessments of the relative position and orientation of bone structures and implants in vivo. While the precision and accuracy of stereophotogrammetry for hip and knee arthroplasty is well documented, there is insufficient knowledge of the technique’s precision and, especially accuracy when applied to rotational movements in the spinal region.

Methods
The motion of one cadaver lumbar spine segment (L3/L4) was analyzed in flexion–extension, lateral bending and internal rotation. The specific aim of this study was to examine the precision and accuracy of stereophotogrammetry in a controlled in vitro setting, taking the surrounding soft tissue into account. The second objective of this study was to investigate the effect of different focal spot values of X-ray tubes.

Results
Overall, the precision of flexion–extension measurements was found to be better when using a 0.6 mm focal spot value rather than 1.2 mm (± 0.056° and ± 0.153°; respectively), and accuracy was also slightly better for the 0.6 mm focal spot value compared to 1.2 mm (− 0.137° and − 0.170°; respectively). The best values for precision and accuracy were obtained in lateral bending for both 0.6 mm and 1.2 mm focal spot values (precision: ± 0.019° and ± 0.015°, respectively; accuracy: − 0.041° and − 0.035°).

Conclusion
In summary, the results suggest stereophotogrammetry to be a highly precise method to analyze motion of the lumbar spine. Since precision and accuracy are better than 0.2° for both focal spot values, the choice between these is of minor clinical relevance.
Nest-site selection in a fish species with paternal care
Authors: Bakker Theo C. M. , Mundwiler Beat 
Published: December 2020

AbstractFish that perform paternal care may increase their fitness by choosing nest sites that enhance survival and development of embryos. We studied nest-site choice with respect to dissolved oxygen concentration and water temperature in males of the three-spined stickleback (Gasterosteus aculeatus), a small fish species with exclusive male parental care that usually breeds in the littoral zone of freshwaters of the Northern hemisphere. Fathers oxygenate the embryos by fanning movements of their pectoral fins. We expected choice for conditions at potential nest sites that would benefit offspring development, i.e., higher temperature and higher dissolved oxygen concentration. In the laboratory, we offered males a choice between two potential nest sites that differed in dissolved oxygen concentration or water temperature. Males preferred to build a nest at sites with a higher dissolved oxygen level or higher temperature and thus chose sites that would promote embryo development.
Melting SNOW-V: improved lightweight architectures
Authors: Caforio Andrea , Balli Fatih , Banik Subhadeep 
Published: December 2020

Abstract is a stream cipher proposed by Ekdahl et al. at IACR ToSC 2019(3) with an objective to be deployed as the encryption primitive in 5G systems. The stream cipher offers 256-bit security and is ready for deployment in the post-quantum era, in which as a rule of thumb (due to Grover’s algorithm), quantum security will vary as the square root of the classical security parameters. The authors further report good software performance figures in systems supporting the instruction set. However, they only provide a theoretical analysis of the cipher’s hardware efficiency. In this paper, we aim to fill this gap. We look at the three most important metrics of hardware efficiency: area, speed and power/energy, and propose circuits that optimize each of these metrics and validate our results using three different standard cell libraries. The smallest circuit we propose occupies only around 4776 gate equivalents of silicon area. Furthermore, we also report implementations which consume as little as 12.7 pJ per 128 bits of keystream and operate at a throughput rate of more than 1 Tbps.
Dickkopf-3 in the prediction of contrast media induced acute kidney injury
Authors: Seibert Felix S. , Heringhaus Anja , Pagonas Nikolaos , Rohn Benjamin , Bauer Frederic , Trappe Hans-Joachim , Landmesser Ulf , Babel Nina , Westhoff Timm H. 
Published: December 2020

Abstract
Background
Dickkopf-3 (DKK3) has recently been discovered as a urinary biomarker for the prediction of acute kidney injury (AKI) after cardiac surgery. This finding needs to be confirmed for AKI in other clinical settings. The present study investigates whether DKK3 can predict contrast-induced AKI (CI-AKI).

Methods
We performed a prospective study in 490 patients undergoing coronary angiography. Primary endpoint was an increase in serum creatinine concentration ≥ 0.3 mg/dl within 72 h after the procedure. DKK3 was assessed < 24 h before coronary angiography. Predictive accuracy was assessed by receiver operating characteristic (ROC) curves.

Results
CI-AKI was observed in 30 (6.1%) patients, of whom 27 corresponded to stage I and 3 to stage II according to the Acute Kidney Injury Network (AKIN) criteria. Subjects who developed CI-AKI had a 3.8-fold higher urinary DKK3/creatinine ratio than those without CI-AKI (7.5 pg/mg [interquartile range [IQR] 1.2–1392.0] vs. 2.0 pg/mg [IQR 0.9–174.0]; p = 0.047). ROC analysis revealed an area under the curve (AUC) of 0.61. Among subjects without clinically overt chronic kidney disease (estimated glomerular filtration rate [eGFR] > 60 ml/min, urinary albumin creatinine ratio < 30 mg/g), the DKK3/creatinine ratio was 5.4-fold higher in those with subsequent CI-AKI (7.5 pg/mg [IQR 0.9–590.1] vs. 1.38 pg/mg [IQR 0.8–51.0]; p = 0.007; AUC 0.62). Coronary angiography was associated with a 43 times increase in the urinary DKK3/creatinine ratio.

Conclusions
Urinary DKK3 is an independent predictor of CI-AKI even in the absence of overt chronic kidney disease (CKD). The study thereby expands the findings on DKK3 in the prediction of postoperative loss of kidney function to other entities of AKI.

Graphic abstract
Ownership and rent stigma: two experiments
Authors: KRICHELI-KATZ TAMAR , POSNER ERIC A. 
Published: December 2020

AbstractWe provide experimental evidence for the existence of “rent stigma,” a preference for owning goods or real estate to renting them. In one experiment, anonymous respondents preferred owning a car or house to renting them, even though the transaction was constructed to be identical in each case in terms of economic payoffs and risk. In a second experiment, a survey of law students who were asked how much they would pay to own rather than rent a laptop found similar results. However, we found little or no evidence for our hypotheses that rent stigma would decline in conditions in which the advantages of renting were made salient. The existence of rent stigma raises concerns that the framing of a transaction in terms of purchasing rather than rent may be used to manipulate consumers.
A randomized trial shows dose-frequency and genotype may determine the therapeutic efficacy of intranasal oxytocin
Authors: Kou Juan , Zhang Yingying , Zhou Feng , Sindermann Cornelia , Montag Christian , Becker Benjamin , Kendrick Keith M 
Published: December 2020

AbstractBackgroundThe neuropeptide oxytocin is proposed as a promising therapy for social dysfunction by modulating amygdala-mediated social-emotional behavior. Although clinical trials report some benefits of chronic treatment, it is unclear whether efficacy may be influenced by dose frequency or genotype.MethodsIn a randomized, double-blind, placebo-controlled pharmaco-functional magnetic resonance imaging trial (150 male subjects), we investigated acute and different chronic (every day or on alternate days for 5 days) intranasal oxytocin (24 international units) effects and oxytocin receptor genotype-mediated treatment sensitivity on amygdala responses to face emotions. We also investigated similar effects on resting-state functional connectivity between the amygdala and prefrontal cortex.ResultsA single dose of oxytocin-reduced amygdala responses to all face emotions but for threatening (fear and anger) and happy faces, this effect was abolished after daily doses for 5 days but maintained by doses given every other day. The latter dose regime also enhanced associated anxious-arousal attenuation for fear faces. Oxytocin effects on reducing amygdala responses to face emotions only occurred in AA homozygotes of rs53576 and A carriers of rs2254298. The effects of oxytocin on resting-state functional connectivity were not influenced by either dose-frequency or receptor genotype.ConclusionsInfrequent chronic oxytocin administration may be therapeutically most efficient and its anxiolytic neural and behavioral actions are highly genotype-dependent in males.
Ethics analysis of light and vitamin D therapies for seasonal affective disorder
Authors: Stanak Michal , Strohmaier Christoph 
Published: December 2020

AbstractObjectiveThe aim of this ethics analysis was to highlight the overt and covert value issues with regard to two health technologies (light therapy and vitamin D therapy), the health technology assessment (HTA) and the disease of seasonal affective disorder (SAD). The present ethics analysis served as a chapter of a full HTA report that aimed to assist decision makers concerning the two technologies.MethodFirst, we used the revised Socratic approach of Hofmann et al. to build overarching topics of ethical issues, and then, we conducted a hand search and a comprehensive systematic literature search on between 12 and 14 February 2019 in seven databases.ResultsThe concrete ethical issues found concerned vulnerability of the target population and the imperative to treat depressive symptoms for the sake of preventing future harm. Further disease-related ethical issues concerned the questionable nature of SAD as a disease, autonomy, authenticity, and capacity for decision making of SAD patients, and the potential stigma related to the underdiagnosis of SAD, which is contrasted with the concern over unnecessary medicalization. Regarding the interventions and comparators, the ethical issues found concerned their benefit-harm ratios and the question of social inequality. The ethical issues related to the assessment process relate to the choice of comparators and the input data for the selected health economic studies.ConclusionsThe concrete ethical issues related to the interventions, the disease, and the assessment process itself were made overt in this ethics analysis. The ethics analysis provided an (additional) value context for making future decisions regarding light and vitamin D therapies.
Exploring the effect of a visual constraint on students’ design cognition
Authors: Ashrafganjouei Mohammadali , Gero John S. 
Published: December 2020

AbstractThis paper presents the results of a study that explores the effect of a visual constraint on design behaviors of architecture students. To examine this effect, 24 second-year architecture students volunteered to participate. Each of them undertook similar conceptual design briefs in two different conditions, one with and another without a visual constraint. Retrospective reporting was used to collect the verbalization of participants. The FBS ontology was used to model the design cognition of the participants by coding their design protocols. A dynamic analysis was used to study the differences between the two conditions based on the problem–solution index. A further index, the pre-structure–post-structure index, was proposed to measure design behavior differences between the two conditions. The correspondence analysis was used to explore the effect of gender. There were statistically significant differences in the distributions of cognitive effort between the two groups. These differences include in the visual constraint group a decrease in the focus on behavior before structure and in the processes related to it, compared to the non-visual constraint group. The non-visual constraint group changed their focus on problem framing and solving while adding a visual constraint led participants to focus simultaneously on both framing and solving. The visual constraint group had a different attention temporally to pre- and post-structure design processes during designing than the non-visual constraint group. The order of experiencing the two design sessions had only a small effect. The results of correspondence analysis demonstrate that there are categorical gender differences not found using statistical testing.
Habermasian Constructivism: An Alternative to the Constitutivist Argument
Authors: Rees Dafydd Huw 
Published: December 2020

AbstractJürgen Habermas’ discourse theory of morality should be understood, in metaethical terms, as a constructivist theory. All constructivist theories face a Euthyphro-like dilemma arising from how they classify the constraints on their metaethical construction procedures: are they moral or non-moral? Many varieties of Kantian constructivism, such as Christine Korsgaard’s, classify the constraints as moral, albeit constitutive of human reason and agency in general. However, this constitutivist strategy is vulnerable to David Enoch’s ‘shmagency’ objection. The discourse theory of morality, by classifying the constraints on the metaethical construction procedure (principles (D) and (U)) as non-moral, can avoid this problem.
A War Time Love Affair:The Round TableandThe New Republic, c.1914–1919
Authors: Kirkwood Patrick M. 
Published: December 2020

AbstractAgainst the backdrop of the Great War a seemingly unlikely transatlantic romance blossomed between the deeply imperialistRound Tablejournal founded by “Milner’s Kindergarten,” a cadre of young former colonial administrators in Great Britain, and the American progressive standard-bearerThe New Republic. The rhetoric ofThe New Republicin these years was deeply influenced by political Anglo-Saxon thought, as exemplified inThe Round Table. Political Anglo-Saxonism was the belief that Anglo-Saxons were uniquely prepared for both self-governance and colonial governance. Adherents judged others’ capacity to self-govern against idealized Anglo norms. BothThe Round Table(1910) andThe New Republic(1914), from their inaugural issues on, sought national solutions for national problems utilizing a shared rhetoric of national efficiency. During the Great War this shared nationalist-progressivism drew the two groups together facilitatingThe New Republic’s founders’ early (1915) embrace of American intervention in the war. These connections are illuminated here through the interactions ofThe New Republicfounders: Herbert Croly, Walter Lippmann, and Walter Weyl with key members of the British Round Table set, including Lionel Curtis, Philip Henry Kerr, Alfred Zimmern, and the prominent American “imperial school” historian George Louis Beer.
A cautionary note on using Mendelian randomization to examine the Barker hypothesis and Developmental Origins of Health and Disease (DOHaD)
Authors: D’Urso Shannon , Wang Geng , Hwang Liang-Dar , Moen Gunn-Helen , Warrington Nicole M. , Evans David M. 
Published: December 2020

AbstractRecent studies have used Mendelian randomization (MR) to investigate the observational association between low birth weight (BW) and increased risk of cardiometabolic outcomes, specifically cardiovascular disease, glycemic traits, and type 2 diabetes (T2D), and inform on the validity of the Barker hypothesis. We used simulations to assess the validity of these previous MR studies, and to determine whether a better formulated model can be used in this context. Genetic and phenotypic data were simulated under a model of no direct causal effect of offspring BW on cardiometabolic outcomes and no effect of maternal genotype on offspring cardiometabolic risk through intrauterine mechanisms; where the observational relationship between BW and cardiometabolic risk was driven entirely by horizontal genetic pleiotropy in the offspring (i.e. offspring genetic variants affecting both BW and cardiometabolic disease simultaneously rather than a mechanism consistent with the Barker hypothesis). We investigated the performance of four commonly used MR analysis methods (weighted allele score MR (WAS-MR), inverse variance weighted MR (IVW-MR), weighted median MR (WM-MR), and MR-Egger) and a new approach, which tests the association between maternal genotypes related to offspring BW and offspring cardiometabolic risk after conditioning on offspring genotype at the same loci. We caution against using traditional MR analyses, which do not take into account the relationship between maternal and offspring genotypes, to assess the validity of the Barker hypothesis, as results are biased in favor of a causal relationship. In contrast, we recommend the aforementioned conditional analysis framework utilizing maternal and offspring genotypes as a valid test of not only the Barker hypothesis, but also to investigate hypotheses relating to the Developmental Origins of Health and Disease more broadly.
Temperature Effect on the Velocity‐Porosity Relationship in Rocks
Authors: Qi Hui , Ba Jing , Müller Tobias M. 
Published: December 2020

AbstractUnderstanding the effect of temperature on physical properties of rocks is important to develop deep oil, gas, and geothermal resources. Velocity‐porosity relations are essential ingredients for a seismic rock physics model. However, relatively little effort has thus far been made to capture the temperature effect on velocity‐porosity relations. To overcome this limitation, we develop a double‐porosity model based on Biot's theory. This model is complemented with the Batzle‐Wang empirical equations for the pressure and temperature dependence of the pore fluid, as well as the David‐Zimmerman model to quantify temperature‐dependent microcrack density. The combined model is tested on carbonate and hyaloclastite samples, for which the variation of ultrasonic P‐wave velocity with temperature has been measured in the laboratory. Comparison of the predicted P‐wave velocity with the measured velocity shows that the proposed model is capable of quantitatively describing the rock velocity‐temperature and velocity‐porosity relations. We found that, for our rock samples, the temperature‐dependent change of microcrack porosity was not the dominant factor affecting the velocity‐porosity relation and that the temperature‐dependent fluid properties had a greater effect. The proposed model also predicts that the velocity dispersion and the attenuation peak of P‐waves in carbonate rock samples become less pronounced with increasing temperature.
Changes in Biomass Turnover Times in Tropical Forests and Their Environmental Drivers From 2001 to 2012
Authors: Wang Jingmeng , Li Wei , Ciais Philippe , Ballantyne Ashley , Goll Daniel , Huang Xiaomeng , Zhao Zhe , Zhu Lei 
Published: December 2020

AbstractTropical forests store about 70% of the total living biomass on land and yet very little is known about changes in this vital carbon reservoir. Changes in their biomass stock, determined by changes in carbon input (i.e., net primary production [NPP]) and carbon turnover time (τ), are critical to the global carbon sink. In this study, we calculated transient τ in tropical forest biomass using satellite‐based biomass and moderate‐resolution imaging spectroradiometer (MODIS) NPP and analyzed the trends of τ and NPP from 2001 to 2012. Results show that τ and NPP generally have opposite trends across the tropics. Increasing NPP and decreasing τ (“N+T−”) mainly distribute in central Africa and the northeast region of South America, while decreasing NPP and increasing τ (“N−T+”) prevail in Southeast Asia and western Amazon forests. Most of the N+T− tropical forest areas are associated with mean annual precipitation (MAP) below 2,000 mm·y−1 and most N−T+ tropical forests with MAP above 2,000 mm·y−1. The τ and NPP trends in the N+T− region are statistically associated with radiation, precipitation and vapor pressure deficit (VPD), while the τ and NPP trends in the N−T+ region are mainly associated with temperature and VPD. Our results inherit the uncertainties from the satellite‐based datasets and largely depend on the carbon use efficiency from MODIS. We thus systematically assessed the robustness of the findings. Our study reveals regional patterns and potential drivers of biomass turnover time and NPP changes and provides valuable insights into the tropical forest carbon dynamics.
Latitudinal Dependence of Daytime Electron Density Bite‐Out in the Ionospheric F2‐Layer
Authors: Chen Yiding , Liu Libo , Le Huijun , Zhang Hui 
Published: December 2020

AbstractDaytime bite‐out in diurnal variations of the F2‐layer electron density often occurs in the equatorial ionosphere, while it was less reported at mid‐latitudes. In this paper, the climatology of daytime bite‐out was investigated using ionosonde measurements in the East Asia sector. The bite‐out can take place at both low‐ and mid‐latitudes and mainly in summer months; and it significantly depends on latitudes. The bite‐out appears as foF2 stays stable or slightly decreases for hours in early morning and then enhances till late afternoon at equatorial ionization anomaly (EIA) crest latitudes. It becomes more significant and durative at mid‐latitudes; foF2 increases and reaches a peak in the morning and then continuously declines till afternoon. In particular, the diurnal variation pattern of foF2 is nearly opposite to that of photoionization at the higher‐latitude station Yakutsk at solar maximum. Moreover, the bite‐out is more remarkable at solar minimum (maximum) than at solar maximum (minimum) at low‐latitudes (mid‐latitudes). The trans‐equator plasma outflow caused by neutral winds and the upward thermal diffusion can result in the bite‐out in the EIA crest region, while the subsequent field‐aligned plasma influx induced by the fountain effect ceases it. At mid‐latitudes, the diurnal variation magnitudes of the thermospheric composition and photoionization production rate are also important factors determining bite‐out degree in addition to neutral wind‐induced downward transport and the upward thermal diffusion.