bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parental monitoring and adolescent health risk behaviors: A comparative analysis of nine Southeast Asian countries
Authors: Vo Thang 
Published: April 2020

Abstract
Background: Strong parental monitoring is thought to protect adolescents from engaging in health risk behaviors. However, differing levels of economic development and regulatory systems suggest that findings from Western countries may not generalize to Southeast Asia. This study analyzed the relationship between parental monitoring and health risk behaviors among adolescents in nine Southeast Asian countries.Methods: Cross-sectional data for 52,803 adolescents (aged 11–18 years; 51.4% female) were obtained from the World Health Organization’s Global School-Based Student Health Survey. Data collected between 2007 and 2015 was available for Indonesia, Myanmar, Thailand, The Philippines, Malaysia, Vietnam, Brunei, Timor-Leste, and Laos. Univariate and multivariate logistic regression analyses were conducted to assess the relationships between parental monitoring, sexual risk behaviors, and substance use. Age, gender, country differences in sexual risk behaviors, and substance use were also examined.Results: The results revealed that adolescents who reported regular parental monitoring had a lower probability of engaging in sexual risk behaviors and substance use. Using alcohol, prohibited substances, and tobacco was significantly associated with engaging in sexual risk behaviors. Males and older participants were more likely than females and younger participants to report all forms of health risk behavior. Significant differences existed in risk behavior between countries, with participants in Timor-Leste the most likely to engage in most forms of health risk behavior.Conclusion: We considered the results in the context of the economic and regulatory environments in each country. In developing countries, particularly those with relatively strong economic growth and relaxed drug and alcohol regulations, parental monitoring, and other factors such as culture, education, and the health system play a crucial role in protecting adolescents from risky behaviors.
An Inconvenient Relationship of Hemoglobin A1c Level with Endothelial Function in Type 2 Diabetes
Authors: Yamaji Takayuki , Harada Takahiro , Hashimoto Yu , Takaeko Yuji , Kajikawa Masato , Han Yiming , Maruhashi Tatsuya , Kishimoto Shinji , Kihara Yasuki , Hida Eisuke , Chayama Kazuaki , Goto Chikara , yusoff Farina Mohamad , Nakashima Ayumu , Higashi Yukihito 
Published: April 2020

Abstract
Background Diabetes is associated with endothelial dysfunction. However, there is little information on the relationship between hemoglobin A1c (HbA1c) level and endothelial function. This study evaluated the relationship between HbA1c level and flow-mediated vasodilation (FMD).Methods We measured FMD in 1215 patients with type 2 diabetes including 349 patients not taking antidiabetic drugs and 866 patients taking antidiabetic drugs. The patients were divided into four groups based on HbA1c levels: <48 mmol/mol, 48–52 mmol/mol, 53–63 mmol/mol, and ≥ 64 mmol/mol. (< 6.5%, 6.5–6.9%, 7.0-7.9%, ≥ 8.0%)Results An inverted U-shaped pattern of association between HbA1c level and FMD was observed at the peak of HbA1c of about 53 mmol/mol (7%). FMD was significantly smaller in the HbA1c < 48 mmol/mol (6.5%) group than in the HbA1c 48–52 mmol/mol (6.5–6.9%) group and HbA1c 53–63 mmol/mol (7.0-7.9%) group (p < 0.001 and p < 0.001), and FMD values were similar in the HbA1c < 48 mmol/mol (6.5%) group and HbA1c ≥ 64 mmol/mol (8.0%) group. There were no significant differences in nitroglycerine-induced vasodilation (NID) values among the four groups. After adjustments for confounding factors, FMD was significantly smaller in the HbA1c < 48 mmol/mol (6.5%) group than in the HbA1c 48–52 mmol/mol (6.5–6.9%) and HbA1c 53–63 mmol/mol (7.0-7.9%) group (p = 0.002 and p = 0.04). In patients not taking antidiabetic drugs, FMD was also significantly smaller in the HbA1c < 48 mmol/mol (6.5%) group than in the HbA1c 48–52 mmol/mol (6.5–6.9%) group and HbA1c 53–63 mmol/mol (7.0-7.9%) group (p < 0.001 and p = 0.02), and there were no significant differences in NID values among the four groups.Conclusions These findings suggest that a low HbA1c level of < 48 mmol/mol (6.5%) is associated with endothelial dysfunction. An HbA1c level of 48–52 mmol/mol (6.5–6.9%) may be appropriate for maintenance of endothelial function.
Predictive values of ANGPTL8 on risk of all-cause mortality in diabetic patients: from the REACTION Study
Authors: Zou Huajie , Chen Xi , Li Danpei , Li Wenjun , Xie Junhui , Shao Shiying , Yu Xuefeng 
Published: April 2020

Abstract
Background: ANGPTL8, an important regulator of glucose and lipid metabolism, is increased in diabetes and associated with insulin resistance. However, the role of ANGPTL8 in diabetes outcomes remains unclear. The study aimed to investigate circulating levels of ANGPTL8 in participants with and without diabetes and its potential association with death and ﻿cardiovascular and renal outcomes in a 5-year cohort study.Methods: Propensity-matched cohorts of subjects with and without diabetes from the ﻿Risk Evaluation of Cancers in Chinese Diabetic Individuals: A longitudinal (REACTION) study was generated on the basis of age, sex and body mass index at baseline. The primary outcome was death from any cause. The secondary outcome was ﻿a composite of new-onset major adverse cardiovascular events, hospitalization for heart failure and ﻿renal dysfunction (eGFR < 60/min/1.73 m2).Results: We identified 769 matched pairs of patients from the diabetes group and the control group. Serum ANGPTL8 levels were elevated in patients with diabetes compared to subjects in the control group﻿ (618.82 318.08 vs. 581.20 299.54, p = 0.03). Furthermore, increasing quartiles of ANGPTL8 were associated with increased all-cause mortality in both the control and diabetes groups (all p values < 0.05). Binary logistic regression analysis showed that ﻿elevated ANGPTL8 levels were associated with greater risk ratios (RRs) of death (RR in quartile 4 vs quartile 1, 3.47; 95% CI 1.30 – 9.29) and renal dysfunction (RR in quartile 4 vs quartile 1, 10.50; 95% CI 1.32 – 83.60) only in diabetic patients. Multivariable-adjusted restricted cubic spline analyses suggested a significant linear ﻿relationship between ANGPTL8 and all-cause mortality in diabetic patients (p for nonlinear trend = 0.99, p for linear trend = 0.01) but not in the controls (p for nonlinear trend = 0.26, p for linear trend = 0.80). According to the ROC curves, the QMortality and QFrailty scores, combined with ANGPTL8, showed better performance in predicting death, especially in diabetic patients.Conclusion: Serum ANGPTL8 levels were associated with an increased risk for all-cause mortality and renal dysfunction in subjects with diabetes. Furthermore, ANGPTL8 had good performance in predicting all-cause mortality in diabetic patients, which may contribute to the early detection of individuals with diabetes at high risk.
Landslide susceptibility mapping using GIS and Remote Sensing: A case study of the Rangamati District, Bangladesh
Authors: Begum Afruja , Islam Md Shofiqul , Hasan Md. Muyeed 
Published: April 2020

Abstract
The landslide is a natural phenomenon and one of the most commonplace disasters in the Rangamati Hill tract area which appeals for better forecasting and specify the landslide susceptible zonation. This research work examines the application of GIS and Remote Sensing techniques based on different parameters such as altitude, slope angle, slope aspect, rainfall, land-use land-cover (LULC), geology and stream distance by heuristic model to identify the landslide susceptible zones for the study area. Among the parameters, rainfall, steep slope, geology and LULC are the dominant factor that triggering the landslide. Clayey or silty soils of the study area during heavy and prolong rainfall behave a flow of debris due to water pressure within the soil, resulting landslides. Steep slope has greater influences for weather zones of the rock-masses for susceptible landslides. Result and field observation indicate that the population density and LULC has a vital effect on landslide within the study area. However, landslide susceptible zones were created based on the susceptibility map of the study area which shows that about 19.43% of the area are at low susceptible zone, 56.55% of the area are at medium susceptible zone, 19.19% of the area are in the high susceptible zone and 4.81% of the area is at the very high susceptible zone.
Lower expression of the RASSF10 gene induces myeloma cell proliferation due to hypermethylation of the gene promoter in multiple myeloma
Authors: Chen Jin , Liu Hui , Liu Zhaoyun , Shao Qing , Jiang Fengjuan , Yan Siyang , Li Lijuan , Song Jia , Ding Kai , Fu Rong 
Published: April 2020

Abstract
Background

Multiple myeloma (MM) is an incurable malignant neoplasm of plasma cells, in which genetic defects, epigenetic aberrations and bone marrow microenvironment are involved in the pathogenesis. RASSF10 acts as a tumor suppressor gene by methylation in glioma and several other cancers, but its role in MM remains unknown.
Methods

In order to explore the role of RASSF10, mRNA expression was detected in MM patients and analyzed with overall survival.
Results

Expression of the RASSF10 gene significantly decreased in newly diagnosed MM patients, and was positively correlated with overall survival. RPMI-8226 and OPM-2 cell lines with lower RASSF10 expression were selected for further study. Overexpression of RASSF10 in these two cell lines inhibited proliferation and induced apoptosis. The RASSF10 gene promoter in MM cell lines was hypermethylated, and downregulated after decitabine treatment. Meanwhile, expression of the RASSF10 gene was upregulated. MM cells with overexpression of RASSF10 were injected into nude mice and exerted anti-MM activity in vivo.
Conclusions

Low expression of RASSF10 contributed to the proliferation of myeloma cells by hypermethylation of its promoter.
Phylogenetic analysis and In silico Screening of drug targets for ACE2 in Human and Spike Glycoprotein in Sars-CoV-2 for control of COVID19
Authors: Dowluru Kaladhar SVGK , Rao Krothapalli. R. S. Sambasiva 
Published: April 2020

Abstract
Coronaviruses are the large group of infectious viruses that affect the respiratory tract and damages lungs. Large part to early Chinese efforts to genome sequencing of Sars-CoV-2, the virus that causes the Covid-19 disease, shared in early January 2020. The sequences from Wuhan seafood market pneumonia virus had different point mutations and are showing non-conserved patterns in between sequences from different regions of world. The present experimentation has shown that bioactive compounds like Nimbin present in Neem plant and Amlaic acid present in Amla are shown as best in the control COVID19. The bioactive compounds like Vitexin present in Bermuda grass and Curcumin present in turmeric powder were also shown good results. Hence usage of Neem, Amla, Bermuda grass and turmeric can boosts immunity and control COVID19. In anti-viral compounds, Remdesivir was found best and effective drug. Lopinavir also find effective drug next to Remdesivir. Hence in higher conditions, combination of remdesivir and lopinavir may be the best way of treatment for COVID19 patients. As antiviral compounds have side effects, Nimbin, Amlaic acid, Vitexin or Curcumin may be better molecules in the treatment of COVID19.
Analysis and research of wireless network simulation technology in swimming sports mechanics
Authors: Xu Zhiwen 
Published: April 2020

Abstract
In order to improve the quantitative teaching level of swimming sports, it is necessary to carry out quantitative analysis of swimming sports mechanics. A method of swimming mechanics analysis based on computer simulation technology is proposed. The ARMA model is used to analyze the mechanics of the limb movement of swimming, the Lagrange dynamics model is used to model the characteristics of the mechanics of swimming movement, and the distributed characteristic parameter model of the dynamics of swimming is analyzed in the space of six degrees of freedom. The dynamic distribution space of swimming motion is obtained by using the forward kinematics analysis model, and the inverse kinematics of multiple degrees of freedom is solved by analytic method, and the global and local joint force and force parameters in swimming are estimated. The model of swimming mechanics is realized. The simulation results show that the proposed method is accurate and accurate in estimating the mechanical parameters of swimming movement, and it can effectively guide swimming training.
The lipid Status and linear relationship between TC and TG in Glycogen Storage Disease Ia
Authors: Zhang Zhenjie , Yuan Yuheng , Ma Mingsheng , Hong Yuehui , Sun Zhixing , Zhang Mengqi , Qiu Zhengqing 
Published: April 2020

Abstract
Background

Glycogen storage disease type I(GSDI) is a glucose metabolic disorder caused by glucose-6-phosphatase deficiency. GSDIa patients are characterized by hypoglycemia, hepatomegaly, hyperlipidemia and lactic acidemia. This study aims to review the lipid status in patients with GSDIa, explores the lipid treatment targets and preferable lipid-lowering drugs.
Methods

The clinical data of GSDIa patients characteristics were collected. Diet control, raw cornstarch were used to maintain normal blood glucose and lipid level. Some patients were given lipid-lowering drugs. We compared the lipid levels before and after each treatment.
Results

A total of 163 GSDIa patients were enrolled in this study and 773 times of lipid levels were detected. TG was normal in only 13 times of detection from 10 patients(2%). There were 26 patients who took atorvastatin or fibrates (fenofibrate or gemfibrozil) regularly for more than one year. The lipid levels could be improved after lipid-lowering drugs treatment. The therapeutic effect of atorvastatin was better than fibrates. The total cholesterol(TC) was positively correlated with total triglycerides(TG) after treatment. A regression equation was established for TC and TG, TG=-2.86 + 1.63TC. The complication of hyperlipidemia was mainly caused by TC. As long as TC maintained normal, TG did not have to be maintained normal and a certain degree of hypertriglyceridemia can be accepted. The lower bound of China Children's TC abnormal level (5.18 mmol/L) was substituted into the established regression equation to obtain TG = 5.58 mmol/L. We set a target that when the TG level was lower than 5.58 mmol / L after treatment, TC could maintain normally. There was no need for further increasing the dosage of lipid-lowering drug.
Conclusion

Patients with GSDIa had significant abnormalities in blood lipid metabolism. We found that there was a linear correlation between TC and TG, which was TG=-2.86 + 1.63*TC. We made a point that as long as the TC remained normal, a certain degree of hypertriglyceridemia could be accepted. We set a target that when the TG level was lower than 5.58 mmol / L after treatment, TC could maintain normally. This study found that the therapeutic effect of atorvastatin was better than fibrates.
Add-on effect of postural instructions to abdominopelvic exercise on urinary symptoms in climacteric women with stress urinary incontinence: A pilot randomized controlled trial.
Authors: Aparicio Laura Fuentes , Bernat Merce Balasch i , Bueno Laura López 
Published: April 2020

Abstract
BackgroundThe aim of this study was to investigate the add-on effect of postural instructions to an abdominopelvic exercise program on urinary symptoms and QoL in perimenopausal, menopausal and postmenopausal women with stress urinary incontinence (SUI).MethodsA randomized controlled trial was performed with a total of 40 perimenopausal, menopausal and postmenopausal women with SUI aged between 46 and 75 years old. Participants were randomly assigned to two groups: a group performing an abdominopelvic exercise program (AEP) (n = 20) and a group performing abdominopelvic exercise with the addition of postural instructions (AEPPI) (n = 20). Primary outcome measures were UI symptoms, UI impact and QoL, measured by 48 h Pad Test and ICIQ-UI-SF, which were assessed at baseline, post-intervention and 3 months follow-up. Secondary outcome was patient’s satisfaction measured by VAS scale only after the intervention.ResultsBetween-groups differences were observed in terms of ICIQ-UI-SF scores inmediately after intervention. Within-groups differences were observed between baseline to 3 months follow-up and between post-intervention to 3 months follow-up in AEPPI group (p < 0.05) for ICIQ-UI-SF and UI impact. UI symptoms were improved in both groups between baseline to 3-months follow-up (p < 0.05). Patient’s satisfaction was higher in AEPPI group (p < 0.05).ConclusionThe addition of postural instructions to an abdominopelvic exercise program improves QoL and patients’ satisfaction in women with SUI.Trial registrationThis study was retrospectively registered at ClinicalTrials.gov under the number NCT03727945, https://clinicaltrials.gov/ct2/show/NCT03727945
Number of parity/live birth(s) and cardiovascular disease among Iranian women and men: Results of over 15 years of follow-up.
Authors: Moazzeni Seyyed Saeed , Toreyhi Hoseein , Asgari Samaneh , Azizi Fereidoun , Tehrani Fahimeh Ramezani , Hadaegh Farzad 
Published: April 2020

Abstract
Background
Most previous studies, conducted in non-Middle Eastern populations, have suggested that increase in the number of parity/live birth(s) leads to cardiovascular disease (CVD) development, although this issue is still controversial among both sexes. Biologic and socioeconomic pathways were suggested to explain this association. We studied this issue among urban Iranian men and women.
Methods
In this population-based cohort study, included 3929 women and 2571 men aged ≥ 30 years, Data for number of parity/live birth(s) were obtained by standard questionnaire. Participants were then annually followed for CVD events. Multivariate Cox proportional hazard models were used to estimate hazard ratios (HRs), and 95% confidence intervals (CIs) for the number of parity/live birth(s) and other traditional CVD risk factors.
Results
During more than 15 years of follow-up, 456 and 524 CVD events have occurred among women and men, respectively. Among women, a J-shaped association was found between the number of live births and incident CVD with the lowest risk for women with 2 live births. Among women in multivariate analyses, each unit increase in parity had a HR of 1.05 (CI: 1.01–1.10) and having ≥ 4 parities was associated with a HR of 1.86 (0.97–3.56, p-value = 0.061). Among men, in comparison with participants who had 1 child, multivariate HRs of having 2, 3 and ≥ 4 children were 1.97 (1.24–3.12), 2.08 (1.31–3.31) and 2.08 (1.30–3.34), respectively.
Conclusion
To the best of our knowledge, the current study is the first report of this issue in the Middle East and North Africa region, a region with high burden of CVD. It can now be suggested that the number of parity/live birth(s) is linked to CVD among the Iranian population, with this issue being more prominent among men. Further research is needed to support our results and clarify the pathways between the number of parity/live birth(s) and CVD development among Iranian populations by considering potential factors, especially psycho-socio-economic factors.
From Dyad to Triad: a Survey on Fathers’ Knowledge and Attitudes Toward Breastfeeding
Authors: Crippa Beatrice Letizia , Consales Alessandra , Morniroli Daniela , Lunetto Flavia , Bettinelli Maria Enrica , Sannino Patrizio , Rampini Serena , Zanotta Lidia , Marchisio Paola , Mosca Fabio , Plevani Laura , Giannì Maria Lorella , Colombo Lorenzo 
Published: April 2020

Abstract
Background
Maternal social support has a critical impact on breastfeeding outcomes. Fathers in particular are known to be especially influential. However, little is known about what they know and how they feel about breastfeeding. We aimed to explore paternal knowledge and attitude toward breastfeeding and possible association with breastfeeding rates at discharge.
Methods
We enrolled fathers of healthy term neonates born at our hospital from March to May 2019. At discharge, a self-administered structured questionnaire was proposed to fathers. Fathers were required to rate their degree of agreement to 12 items on a 5-point Likert scale. A total score was obtained from their answers. Subjects’ basic characteristics and mode of feeding at discharge were collected.
Results
Fathers showed a generally solid knowledge of maternal (87%) and neonatal (98%) benefits of breastfeeding, skin-to-skin contact (99.5%), rooming-in practice (79%) and responsive feeding (67.5%); conversely, only 51% of them knew about the recommended use of pacifiers. Fathers felt personally involved in their babies’ feeding in 79% of cases, regardless of type of feeding. A positive correlation was found between total score and exclusive breastfeeding rates at discharge (p = 0.04, OR 1.07; 95%C.I 1.002–1.152). ROC analysis showed a trend toward statistical significance (AUC 0.58, p = 0.083, 95%C.I 0.485–0.683).
Conclusions
This study underlines the importance of including fathers in the promotion of breastfeeding, expanding the classic mother-baby dyad to a more modern mother-father-baby triad. This may ultimately impact breastfeeding outcomes, although further studies are needed to confirm our results.
Prognostic impact of the prognostic nutritional index in cases of resected oral squamous cell carcinoma: a retrospective study
Authors: Abe Atsushi , Hayashi Hiroki , Ishihama Takanori , Furuta Hiroshi 
Published: April 2020

Abstract
Background
The systemic inflammatory response and nutritional status of the patients are related to postoperative results in malignant tumors. We examined the usefulness of the prognostic nutritional index (PNI) as a prognostic factor in patients with oral squamous cell carcinoma who underwent radical surgery.
Methods
From 2008 to 2019, 102 patients (73 males, 29 females, age, 65.6 ± 9.8 years) who visited our hospital and underwent surgical therapy were included in this study. The endpoint was the total survival period, and the evaluation items included the lymphocyte count and albumin levels in the peripheral blood obtained within 4 weeks preoperatively, as well as age, sex, alcohol consumption and smoking history, site of the tumor, pathological stage, and surgery status. The PNI was calculated using serum albumin levels and the peripheral blood lymphocyte count. The relationships between the PNI and patient characteristics were analyzed using Fisher's exact test. The Kaplan–Meier method was used to evaluate the survival rate. The survival periods were compared using the log-rank method. We evaluated the prognostic factors for the overall survival (OS) in a logistic regression model.
Results
The tumor sites included the maxilla (n = 12), buccal mucosa (n = 11), mandible (n = 17), floor of the mouth (n = 9), and tongue (n = 53). The number of patients with stage I, II, III, and IV oral cancers was 28 (27.5%), 34 (27.5%), 26 (33.3%), and 14 (13.7%), respectively. During the observation period, 21 patients died of head and neck cancer. The optimal cut-off PNI value was 42.9 (range: 38.8–49.4) according to the receiver operating characteristic analysis. The proportion of patients with a short OS was lower in those with PNI higher than 42.9, and the 5-year OS in patients with PNI higher and lower than the cut-off value was 62.3% and 86.0%, respectively (P = 0.0105).
Conclusions
The OS of patients with PNI ≤ 42.9 was lower than that of patients with PNI greater than 42.9. The PNI, which is a preoperative head-to-foot inflammatory marker, can help estimate the prognosis of oral cancer.