bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic value of a three-dimensional dynamic quantitative analysis system to measure facial motion in acute facial paralysis patients
Authors: Zhao Yang , Feng Guodong , Wu Haiyan , Aodeng Surita , Tian Xu , Volk Gerd Fabian , Guntinas-Lichius Orlando , Gao Zhiqiang 
Published: July 2020

AbstractBackgroundTo investigate the prognostic value of a three-dimensional dynamic quantitative analysis system to measure facial motion (3D ASFM) in acute facial palsy patients and compare it with subjective grading methods and electroneurography.MethodsWe continuously recruited 37 patients with acute (< 1 month) Bell’s palsy. An integrated evaluation of facial palsy was performed for each patient. The integrated evaluation included the House-Brackmann grading system (H-BGS), Sunnybrook Facial Grading System (SFGS), electroneurography and three-dimensional objective measurements. Then, the entire set of evaluations were repeated for each patient 1 month later. The patients were followed up monthly until recovery or for up to more than 6 months. We adopted the SFGS and H-BGS as the representative subjective grading system and final criteria for recovery. Poor recovery was defined as an SFGS score less than 70 or H-BGS score higher than II.ResultsMultiple regression analysis was performed to find the best prognostic indicators. In less than 1 month from onset, ENoG had the highest prognostic value. However, in the second month from onset, the results of SFGS and 3D ASFM were identified as the best prognostic parameters, and a prediction formula with a determination coefficient of 0.673 was established. The receiver operating characteristic curves revealed that a gross score of the 3D ASFM less than 31 in the first evaluation and 49 in the second evaluation had higher sensitivity and specificity to predict poor recovery.ConclusionsIn different phases of Bell’s palsy, the best predictor of prognosis is different. ENOG is the most effective predictor of the prognosis in the first month after onset. In the second month after onset, the combination of SFGS and 3D ADSM is considered to be the best prognostic predictor.
Validation and psychometric properties of the community assessment inventory in Iranian persons who use drug
Authors: Salari Nader , Jalali Amir , Abdam Behzad , Abdi Alireza , Daryoushi Hooman 
Published: July 2020

Abstract
Objective
Social support is a key factor in the treatment and rehabilitation process of persons who use drug (PWUD). This highlights the need for a valid and reliable tool for assessing social support. The cultural and psychometric properties of community assessment inventory (CAI) in PWUDs under methadone therapy were examined in Iran in 2019.

Methods
The study was carried out as a validation and methodological study. At first, the original tool was translated into Farsi using forward-backward method. After ensuring face validity and content validity, construct reliability of the tool was supported using explorative and confirmatory factor analysis (EFA & CFA) using a sample group of 392 participants. The participants were selected through convenient-quota sampling from 24 drug clinics. Reliability of the questionnaire was supported using Pearson correlation coefficient and internal consistency based on Cronbach’s alpha.

Results
To determine content validity of the tool, CVI and CVR of it were obtained, which were on average equal to 0.79 and 0.59 respectively. The EFA supported correlation of the 37itmes of the tool (KMO = 0.975, Chi-square = 15,051.6, Pvalue=0.0001). The main indices of the model, based on CFA were higher than 0.9, which support goodness of fit of the model (χ2/DF = 2.98, CFI = 0.91, NFI, TLI = 0.905 GF = 0.92, REMSEA = 0.07, R2 = 0.99). Reliability of the tool based on internal consistency (Cronbach’s alpha) for the subscales were in 0.8–0.95 interval and equal to 0.85 for the whole tool.

Conclusion
As the results showed, CAI had acceptable indices for Iranian PWUDs under methadone therapy. The tool can be used for assessing social support level in the study population. It is a reliable and valid tool for studies in pertinent fields.
What is the impact of a novel MED12 variant on syndromic conotruncal heart defects? Analysis of case report on two male sibs
Authors: Amodeo Silvia , Vitrano Giuseppe , Guardino Melania , Paci Giuseppe , Corselli Fulvio , Antona Vincenzo , Barrano Giuseppe , Magliozzi Monia , Novelli Antonio , Venezia Renato , Corsello Giovanni 
Published: July 2020

Abstract
Background
Syndromic congenital heart disease accounts for 30% of cases and can be determined by genetic, environmental or multifactorial causes. In many cases the etiology remains uncertain. Many known genes are responsible for specific morphopathogenetic mechanisms during the development of the heart whose alteration can determine specific phenotypes of cardiac malformations.

Case presentation
We report on two cases of association of conotruncal heart defect with facial dysmorphisms in sibs. In both cases the malformations’ identification occurred by ultrasound in the prenatal period. It was followed by prenatal invasive diagnosis. The genetic analysis revealed no rearrangements in Array-CGH test, while gene panel sequencing identified a new hemizygous variant of uncertain significance (c.887G > A; p.Arg296Gln) in the MED12 gene, located on the X chromosome and inherited from the healthy mother.

Conclusion
No other reports about the involvement of MED12 gene in syndromic conotruncal heart defects are actually available from the literature and the international genomic databases. This novel variant is a likely pathogenic variant of uncertain significance and it could broaden the spectrum of genes involved in the development of congenital heart diseases and the phenotypic range of MED12-related disorders.
Aggressive refractory pemphigus vulgaris that responded to plasmapheresis: a case report
Authors: Khaddour Hiba Hasan , Zaher Diana , Kassem Triak , Hasan Ahmad 
Published: July 2020

Abstract
Background
Pemphigus vulgaris is an autoimmune disorder that involves intraepithelial blistering and sores of the skin and mucous membranes. The average age of onset is between 50 and 70 years. Pemphigus rarely occurs in children. It correlates with the level of circulating autoantibodies; therapeutic plasma exchange is hypothesized to remove pathogenic autoantibodies, and this is necessary in refractory severe cases.

Case presentation
A 14-year-old Asian girl came to our hospital with blisters and erosions all over her body and in the oral mucosa. She was diagnosed with pemphigus vulgaris by skin biopsy about 3 months before hospitalization. She was admitted to the intensive care unit due to aggressively worsening symptoms, extensive lesions, dehydration, and electrolyte imbalance secondary to excess fluid loss from the skin wounds and sepsis secondary to infection of the exposed wounds. She did not respond to prednisone and azathioprine therapy but was successfully treated with plasmapheresis.

Conclusion
The purpose of this case report is to describe an aggressive presentation of pemphigus vulgaris, especially because the onset of the disease in our patient was at an early age. The disease rarely begins in childhood, and this case report highlights the importance of plasmapheresis as a useful intervention in patients with pemphigus vulgaris who are not responding to conventional therapy, taking into account that there is a paucity of studies showing the effectiveness of plasmapheresis in inducing partial or complete remission in young patients.
Effectiveness of exergames for improving mobility and balance in older adults: a systematic review and meta-analysis
Authors: Pacheco T. B. F. , de Medeiros C. S. P. , de Oliveira V. H. B. , Vieira E. R. , de Cavalcanti F. A. C. 
Published: July 2020

Abstract
Background
Exergaming is a fun, engaging, and interactive form of exercising that may help overcome some of the traditional exercise barriers and help improve adherence on the part of older adults, providing therapeutic applications for balance recovery and functional mobility. The purpose of this systematic review is to summarize the effects of exergames on mobility and balance in older adults.

Methods
The PRISMA guidelines for systematic reviews were followed. The following databases were searched from inception to August 2019: Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, PEDro, CINAHL, and INSPEC. We selected randomized controlled trials that assessed the effects of exergames on balance or mobility of older adults without neurological conditions, in comparison to no intervention or health education. Two review authors independently screened the trials’ titles and abstracts and identified trials for inclusion according to the eligibility criteria. An almost perfect agreement between the authors was observed with respect to interrater reliability of trial selection (kappa = 0.84; P < 0.001). We performed descriptive analysis of the quantitative data to summarize the evidence. Meta-analysis was carried out using RevMan. A random effects model was used to compute the pooled prevalence with 95% confidence intervals.

Results
After screening 822 records, 12 trials comparing exergames with no intervention were included. A total of 1520 older adults participated in the studies, with a mean age of 76 ± 6 years for the experimental group and 76 ± 5 years for the control group. Quantitative synthesis showed significant improvements in balance and mobility based on the center of pressure sway (SMD = − 0.89; 95%CI = − 1.26 to − 0.51; P = 0.0001; I2 = 58%), Berg Balance Scale (MD = 2.15; 95%CI = 1.77 to 2.56; P = 0.0001; I2 = 96%), and on Timed Up and Go test (MD = − 2.48; 95%CI = − 3.83 to − 1.12; P = 0.0003; I2 = 0).

Conclusions
Exergames improved balance and mobility in older adults without neurological disorders and motivate patients to keep performing balance exercises. High quality studies with standardized assessment protocols are necessary to improve the strength of the evidence.
On generalized fractional integral inequalities for the monotone weighted Chebyshev functionals
Authors: Rahman Gauhar , Nisar Kottakkaran Sooppy , Ghanbari Behzad , Abdeljawad Thabet 
Published: July 2020

AbstractIn this paper, we establish the generalized Riemann–Liouville (RL) fractional integrals in the sense of another increasing, positive, monotone, and measurable function Ψ. We determine certain new double-weighted type fractional integral inequalities by utilizing the said integrals. We also give some of the new particular inequalities of the main result. Note that we can form various types of new inequalities of fractional integrals by employing conditions on the function Ψ given in the paper. We present some corollaries as particular cases of the main results.
Topological degree theory and Caputo–Hadamard fractional boundary value problems
Authors: Amara Abdelkader , Etemad Sina , Rezapour Shahram 
Published: July 2020

AbstractWe study two hybrid and non-hybrid fractional boundary value problems via the Caputo–Hadamard type derivatives. We seek the existence criteria for these two problems separately. By utilizing the generalized Dhage’s theorem, we derive desired results for an integral structure of solutions for the hybrid problems. Also by considering the special case as a non-hybrid boundary value problem (BVP), we establish other results based on the existing tools in the topological degree theory. In the end of the article, we examine our theoretical results by presenting some numerical examples to show the applicability of the analytical findings.
Existence results of fractional delta–nabla difference equations via mixed boundary conditions
Authors: Reunsumrit Jiraporn , Sitthiwirattham Thanin 
Published: July 2020

AbstractIn this article, we purpose existence results for a fractional delta–nabla difference equations with mixed boundary conditions by using Banach contraction principle and Schauder’s fixed point theorem. Our problem contains a nonlinear function involving fractional delta and nabla differences. Moreover, our problem contains different orders in four fractional delta differences, four fractional nabla differences, one fractional delta sum, and one fractional nabla sum. Finally, we present some illustrative examples.
A multimodal intervention to improve hand hygiene compliance in peripheral wards of a tertiary care university centre: a cluster randomised controlled trial
Authors: Aghdassi Seven Johannes Sam , Schröder Christin , Lemke Elke , Behnke Michael , Fliss Patricia Manuela , Plotzki Carolin , Wenk Janina , Gastmeier Petra , Kramer Tobias Siegfried 
Published: July 2020

Abstract
Background
Interventions to improve hand hygiene (HH) compliance are a key element in the practice infection prevention and control. It was our objective to assess the effect of a multimodal intervention on HH compliance at a tertiary care university hospital. As a secondary objective, we investigated the effect of the intervention on the occurrence of device-associated bloodstream infections.

Methods
We performed a single centre cluster randomised controlled trial at a university hospital in Germany. Twenty peripheral wards were invited to participate and randomly assigned to either the intervention (n = 10) or control group (n = 10). Quarterly, specifically trained student employees conducted direct compliance observations in all twenty wards. The intervention entailed dissemination of teaching materials on aseptic procedures, equipment with flexibly mountable alcoholic hand rub dispensers, and quarterly feedback on HH compliance.

Results
In total, 21,424 HH opportunities were observed. Overall, compliance did not change significantly in either group (intervention group: 59% vs. 61% (1482 HH actions for 2494 HH opportunities vs. 5033 HH actions for 8215 HH opportunities), odds ratio (OR) 1.08 (95% confidence interval (CI95) 0.88, 1.33)); control group: 59% vs. 60% (1457 HH actions for 2484 HH opportunities vs. 4948 HH actions for 8231 HH opportunities), OR 1.06 (CI95 0.84, 1.35)). Compliance prior to aseptic procedures improved significantly in the intervention group from 44% (168 HH actions for 380 HH opportunities) to 53% (764 HH actions for 1452 HH opportunities) (OR 1.40 (CI95 1.04, 1.89), p = 0.03), while no significant increase was noted in the control group. In the intervention group, significantly fewer device-associated bloodstream infections per 1000 patient-days occurred than in the control group (84 vs. 123, incidence rate ratio 0.61 (CI95 0.46, 0.81), p < 0.01).

Conclusions
The lack of a significant overall improvement of HH compliance demonstrated that comprehensive implementation of HH interventions in multiple wards simultaneously is difficult. However, through targeted intervention measures, we were able to significantly increase HH compliance before aseptic procedures.
Spatial estimation of soil erosion using RUSLE modeling: a case study of Dolakha district, Nepal
Authors: Thapa Pawan 
Published: July 2020

AbstractBackgroundSoil erosion causes topsoil loss, which decreases fertility in agricultural land. Spatial estimation of soil erosion essential for an agriculture-dependent country like Nepal for developing its control plans. This study evaluated impacts on Dolakha using the Revised Universal Soil Loss Equation (RUSLE) model; analyses the effect of land use and land cover (LULC) on soil erosion.ResultsThe soil erosion rate categorized into six classes based on the erosion severity, and 5.01% of the areas found under extreme severe erosion risk (> 80 Mg ha−1 year−1) addressed by decision-makers for reducing its rate and consequences. Followed by 10% classified between high and severe range from 10 to 80 Mg ha−1 year−1. While 15% and 70% of areas remained in a moderate and low-risk zone, respectively. Result suggests the area of the north-eastern part suffers from a high soil erosion risk due to steep slope.ConclusionsThe result produces a spatial distribution of soil erosion over Dolakha, which applied for conservation and management planning processes, at the policy level, by land-use planners and decision-makers.
Social innovation for health: engaging communities to address infectious diseases
Authors: Dako-Gyeke Phyllis , Amazigo Uche V. , Halpaap Beatrice , Manderson Lenore 
Published: July 2020

AbstractUniversal health coverage emphasises the value of the community-based delivery of health services to ensure that underserved populations have access to care. In areas where infectious diseases are endemic, there are often few resources and limited capacity, and the introduction of effective and accessible strategies require innovation. In this special issue, the contributing authors emphasise the power of local responses to the circumstances that underpin diseases of poverty, and highlight the methodological and programme innovations necessary to support and sustain these responses. Through case studies, the authors illustrate how social innovations can address health inequities, and they identify the role of academics in the Social Innovation in Health Initiative to support this approach.
Orbital Rosai-Dorfman disease initially diagnosed as IgG4-related disease: a case report
Authors: Iyengar Nishanth S. , Golub Danielle , McQuinn Michelle W. , Hill Travis , Tang Karen , Gardner Sharon L. , Harter David H. , Sen Chandranath , Staffenberg David A. , Thomas Kristen , Elkin Zachary , Belinsky Irina , William Christopher 
Published: July 2020

AbstractInflammatory orbital lesions include a broad list of diagnoses, many of them with overlapping clinical and radiographic features. They often present a diagnostic conundrum, even to the most experienced orbital specialist, thus placing considerable weight on surgical biopsy and histopathological analysis. However, histopathological diagnosis is also inherently challenging due to the rarity of these lesions and the overlaps in histologic appearance among distinct disease entities. We herein present the case of an adolescent male with a subacutely progressive orbital mass that generated a significant diagnostic dilemma. Early orbital biopsy was consistent with a benign fibro-inflammatory lesion, but corticosteroid therapy was ineffective in halting disease progression. After an initial substantial surgical debulking, histopathological analysis revealed several key features consistent with IgG4-related disease (IgG4-RD), a systemic fibro-inflammatory process typically accompanied by multifocal tumor-like lesions. Surprisingly, within months, there was clear evidence of clinical and radiographic disease progression despite second-line rituximab treatment, prompting a second surgical debulking. This final specimen displayed distinctive features of Rosai-Dorfman disease (RDD), a systemic inflammatory disease characterized by uncontrolled histiocytic proliferation. Interestingly, certain features of this re-excision specimen were still reminiscent of IgG4-RD, which not only reflects the difficulty in differentiating RDD from IgG4-RD in select cases, but also illustrates that these diagnoses may exist along a spectrum that likely reflects a common underlying pathogenetic mechanism. This case emphasizes the importance of surgical biopsy or resection and histopathological analysis in diagnosing—and, ultimately, treating—rare, systemic inflammatory diseases involving the orbit, and, furthermore, highlights the shared histopathological features between RDD and IgG4-RD.
Clinical outcomes with a new design in multifocal intraocular lens: a pilot study
Authors: Alió Jorge L. , Yébana Pilar , Cantó Mario , Plaza Ana B. , Vega Alfredo , Alió del Barrio Jorge L. , Lugo Francisco 
Published: July 2020

Abstract
Purpose
To evaluate the clinical and visual outcomes, quality of near vision and the influence of photic phenomena in patients bilaterally implanted with a new Precizon Presbyopic multifocal intraocular lens (IOL).

Methods
In this prospective consecutive case series, 20 eyes of 10 patients were included (mean age 63.80 ± 12.55 years). Uncorrected and corrected visual acuity (far, intermediate and near), subjective refraction, binocular defocus curve, contrast sensitivity (CSV-1000) and quality of vision and satisfaction questionnaires were measured. The follow-up was 12 months after surgery.

Results
At 12 months after surgery, uncorrected distance visual acuity (UDVA) improved with surgery (p = 0.001) with a value of 0.08 ± 0.08 logMAR. Uncorrected near visual acuity (UNVA) was 0.22 ± 0.12 logMAR and distance corrected near visual acuity (DCNVA) was 0.16 ± 0.13 logMAR. Intermediate distance visual acuity (UIVA) was 0.22 ± 0.10 logMAR. Contrast sensitivity outcomes were similar to normal population in photopic conditions and slightly reduced in mesopic conditions of lighting. Defocus curve showed that this multifocal IOL was able to provide a visual acuity (VA) equal or better to 0.16 logMAR between defocus levels of + 1.00 to − 2.50 D. Good patient satisfaction was obtained in quality of vision and satisfaction questionnaires outcomes.

Conclusions
The Precizon Presbyopic NVA IOL (OPHTEC BV) provides good visual outcomes. This multifocal IOL provides a high percentage of spectacle independence due to good VA at far, intermediate and near distances and satisfactory contrast sensitivity. High patient satisfaction was observed in quality of vision and satisfaction questionnaires with a low percentage of patients manifesting photic phenomena.
Fertility patients’ use and perceptions of online fertility educational material
Authors: Jones Claire Ann , Mehta Chaula , Zwingerman Rhonda , Liu Kimberly E. 
Published: July 2020

Abstract
Background
Online educational information is highly sought out by patients with infertility. This study aims to assess patient-reported usage and helpfulness of fertility educational material on a clinic website and social media accounts.

Methods
Educational material was created on common fertility topics in text and video format and posted on the clinic website and social media accounts. At the first consultation for infertility, patients were provided with a postcard directing them to material online. At the first follow-up appointment, patients were invited to fill out a survey assessing whether patients viewed the online educational material and if they found the information helpful.

Results
98.4% (251/255) of patients completed the survey, of which 42.6% (106/249) looked at the online material. Of those who viewed the online information, 99.1% (115/116) found the information helpful or somewhat helpful and 67.6% (73/108) found reading the material online better prepared them for making fertility decisions at their doctor’s appointment

Conclusion
Patients found online fertility information on the clinic website and social media accounts useful for making fertility treatment decisions. Providing online educational material has the potential to improve patient care by empowering patients with the knowledge to make more informed treatment decisions, and improving the quality of the time spent with the physician.