bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flow diverter versus stent-assisted coiling treatment for managing dissecting intracranial aneurysms: A systematic review and meta-analysis
Authors: Brenner Leonardo O. , Prestes Milena Zadra , Soares Cid , Romeiro Pedro , Gomez Victor A. , Rabelo Nicollas Nunes , Welling Leonardo C. , Koester Stefan W. , Pinheiro Agostinho C. , Batista Sávio , Bertani Raphael , Figueiredo Eberval Gadelha , Cavalcanti Daniel Dutra 
Published: December 2024

Background Dissecting intracranial aneurysms (DIAs) have been treated through endovascular reconstructive manners, such as flow diverters (FDs) and stent-assisted coiling (SAC). Notably, no robust evidence has compared both approaches. Hence, the authors conducted a meta-analysis to compare their outcomes. Methods PubMed, Embase and Web of Science were searched for studies employing SAC and FD treatment for DIAs. The following outcomes were considered for extraction: procedure-related mortality, total mortality, postoperative and follow-up complete aneurysm occlusion, complications, good clinical outcomes, recurrence, and retreatment. Odds ratio (OR) with random effects was employed for statistical comparison. Results The meta-analysis included 10 studies. A total of 195 and 222 patients were included in the FD and the SAC group, respectively. Stent-assisted coiling had higher postoperative complete aneurysm occlusion rates (OR 0.03; 95% CI 0.01–0.08). Flow diverter retreatment rate was lower, but without statistical significance (OR 0.35; 95% CI 0.11–1.10). No significant differences were found in follow-up complete aneurysm occlusion (OR 1.18; 95% CI 0.35–3.99); total mortality (OR 0.44; 95% CI 0.09–2.08); intraoperative complications (OR 0.30; 95% CI 0.06–1.45); postoperative complication (OR 0.77; 95% CI 0.35–1.70); good clinical outcomes (OR 0.97; 95% CI 0.43–2.20); and recurrence (OR 0.38; 95% CI 0.13–1.10) between the two groups. Conclusion Stent-assisted coiling shows higher postoperative complete aneurysmal occlusion rates, but both techniques achieve similar rates in angiographic follow-up. Flow diverter has lower, but not statistically significant, retreatment rates than SAC. Both techniques have similar complication rates. Future randomized, multicenter, and prospective studies with larger sample sizes are needed for more conclusive findings.
Digital communication media and maternal health education: Integration of bibliometric analysis, methodological analysis, and meta-synthesis
Authors: Mulyani Erry Yudhya , Rakhmawati Tri , Damayanti Sih , Sumaedi Sik 
Published: December 2024

Introduction Information and communication technology advances have resulted in new communication channels, namely digital communication media, that can support maternal health education. Objective This study examines the current research situation on the use of digital communication media in the context of maternal health education. Methods The papers were collected from the Scopus database. Bibliometric analysis, methodological analysis, and meta-synthesis were performed to achieve the research objectives. Of the 426 papers, 316 were included in the filtering process (published in journals and English). A total of 98 papers were included in the analysis stage, with criteria that the paper must contain empirical studies, discuss digital communication media (maternal-health education), and the research subject is pregnant women. Results The bibliometric analysis results show the top authors (authors with the most publications and citations), top countries, top journals, top papers, and the research collaborations on the topic. The four theme groups in the meta-synthesis show that digital communication media has been widely utilized and is an effective tool for maternal health education. The USA, Australia, and Iran are the countries where most research is on digital communication media (maternal health education). The most researched digital communication media are mobile apps and social media. Most studies on this topic used a quantitative approach with experiments as a data collection procedure. Conclusion Several research gaps proposed in this study were exploring perceptions and acceptance of pregnant women regarding maternal health education, maternal education based on country context, and further research by considering the relevant theories.
Visual analysis of research trends and hotspots in wearable electronic devices in the medical field: A bibliometric study
Authors: Zhang Ni , Peng Yanyang , Guo Qing 
Published: December 2024

Background Healthcare services and functionalities need comprehensive upgrades, and advancements in information technology have driven research in wearable electronic devices (WDs), making them critical tools for this purpose. Objective To conduct a systematic bibliometric analysis of WDs in the medical field and understand research trends. Methods A literature search of articles related to WDs in the medical field was conducted in the Web of Science Core Collection (WoSCC) from 2013 to 2023. Articles were analyzed using CiteSpace 6.1.R6. Results Publications on WDs have increased yearly since 2014, peaking in 2021. The United States leads with 935 articles. PLOS One is the top journal, and Bland et al. have the highest citation frequencies. Hot topics include mobile apps, phones, and neural networks, with research on physical activity, sleep monitoring, and atrial fibrillation. Conclusions This study identifies key journals, countries, institutions, and authors in WDs research, highlighting trends and global interest in health monitoring and assessment. The United States leads in research, with future trends focusing on neural network monitoring, accuracy improvements, cloud storage, and advancements in healthcare management systems.
Chronic Disease Management in a Nurse Practitioner-Led Clinic: An Interpretive Description Study
Authors: Floriancic Natalie , Garnett Anna , Donelle Lorie 
Published: December 2024

Introduction Nurse practitioner-led clinics (NPLC) represent a model of care that has the potential to enhance primary healthcare delivery to community-dwelling adults who are living with chronic disease by providing greater access and continuity of care and reducing the burden on acute care settings. However, there is limited understanding of nurse practitioners’ experiences and perspectives on supporting adults in chronic disease management within an NPLC model of care. Increased understanding would contribute to our ability to evaluate the effectiveness of the NPLC model of care for chronic disease management. Objective This study explored current chronic disease management practices implemented by nurse practitioners within NPLC throughout the Province of Ontario. Methods A qualitative study was implemented using interpretive description. In-depth interviews were conducted between January 2021 and May 2021 with nurse practitioners who were practicing within NPLCs across Ontario. Data was analyzed using thematic analysis. Results Eleven interviews were completed with nurse practitioners who provided care to community-dwelling adults who were managing chronic disease in a range of geographic settings. Resultant themes included: the nurse practitioner role in bridging access to patients who fall between the cracks, benefits of interprofessional care, meeting a patient where they are at, and addressing healthcare system burden. Conclusion Results suggest that NPLCs are well-positioned to support community-based patients living with chronic disease through provision of on-site interprofessional care, continuity in service provision and increased access to primary healthcare services. This article provides insights into the nurse practitioner led primary healthcare model and how it can facilitate access to services, foster patient self-management and provide a successful alternative model of care.
Factors associated with tetanus toxoid vaccine utilization among reproductive-age women in Debre Markos town, Ethiopia, 2021: a cross-sectional study
Authors: Tamiru Yihunnie Dessie , Sendo Endalew Gemechu , Deressa Jembere Tesfaye 
Published: December 2024

Background: The risk of neonatal tetanus infection will be reduced when the pregnant woman takes two doses of the maternal tetanus toxoid vaccine. In Ethiopia, however, low immunization coverage levels, mostly due to missed opportunities, are a concern. The study’s main objective of the study was to assess tetanus toxoid immunization utilization coverage and associated factors among postnatal mothers in Debre Markos town, Ethiopia. Materials and Methods: A community-based cross-sectional study was conducted among 505 mothers who had given birth in the last 12 months. A two-stage stratified sampling technique was applied, and the The participants were selected using a systematic random sampling technique. Data were entered into EpiData manager version 4.6.0 and analyzed using Statistical Package for Social Science (SPSS) version 25 software. Bivariable and multivariable logistic regression analysis was performed. Adjusted odds ratios (AORs) at 95% CIs were used to identify factors associated with tetanus toxoid immunization utilization. Results: The total tetanus vaccine intake (TT+2) doses were 71.2% (95% CI: 67.4–76.2). Mothers who attended primary school (AOR: 0.07, 95% CI: (0.01–0.6)), mothers whose husbands had secondary education (AOR: 0.26, 95% CI: (0.08–0.84)), mothers who attended 2–3 times antenatal care (ANC) visit (AOR: 0.05, 95% CI: (0.01–0.3)), good quality service (AOR: 2.8, 95% CI: (1.05–7.5)), appropriate behavior of health workers (AOR: 6.2, 95% CI: (2.2–18.7)), and who visited health extension workers (AOR: 7.6, 95% CI: (2.3–25.3)) were significantly associated with TT vaccine utilization. Conclusion: Only three out of four pregnant women received the current TT vaccine during their previous pregnancy. The most influencing factors in TT vaccine utilization were the mother and her husband’s low educational level, 2–3 times ANC visits during pregnancy, the standard of healthcare service, the healthcare provider’s behavior, and the mother’s visits with health extension staff.
Over 400 food resources from Brazil: evidence-based records of wild edible mushrooms
Authors: Drewinski Mariana P. , Corrêa-Santos Marina Pires , Lima Vitor X. , Lima Felipe T. , Palacio Melissa , Borges Maria Eduarda A. , Trierveiler-Pereira Larissa , Magnago Altielys C. , Furtado Ariadne N. M. , Lenz Alexandre R. , Silva-Filho Alexandre G. S. , Nascimento Cristiano C. , Alvarenga Renato L. M. , Gibertoni Tatiana B. , Oliveira Jadson J. S. , Baltazar Juliano M. , Neves Maria Alice , Vargas-Isla Ruby , Ishikawa Noemia K. , Menolli Nelson 
Published: December 2024

AbstractMany species of mushroom-forming fungi have been harvested in the wild and used for food and medicine for thousands of years. In Brazil, the knowledge of the diversity of wild edible mushrooms remains scattered and poorly studied. Based on new samples, bibliographic records revision, and searches through the GenBank, we recorded 409 species of wild edible mushrooms in Brazil, of which 350 can be safely consumed and 59 are edible but with conditions. Additionally, other 150 species represent taxa with unclear evidence of consumption or unconfirmed edibility status. A total of 86 of the 409 edible species represents consistent records in Brazil based on molecular data and/or Brazilian nomenclatural types. Other 323 names represent species that need further taxonomic investigations to confirm their identity and occurrence in the country, with 41 of them having some record of consumption by part of the Brazilian population. The remaining 282 species can represent new food resources for the country. We generated 143 DNA sequences, representing 40 species within 29 genera. Edible mushrooms are an important non-wood forest product and the knowledge about them adds value to the local biodiversity and the population, increasing the incentive to conservation allied to sustainable rural development.
Potato steroidal glycoalkaloids: properties, biosynthesis, regulation and genetic manipulation
Authors: Liu Yongming , Liu Xiaowei , Li Yingge , Pei Yanfei , Jaleel Abdul , Ren Maozhi 
Published: December 2024

AbstractSteroidal glycoalkaloids (SGAs), predominantly comprising α-solanine (C45H73NO15) and α-chaconine (C45H73NO14), function as natural phytotoxins within potatoes. In addition to their other roles, these SGAs are crucial for enabling potato plants to withstand biotic stresses. However, they also exhibit toxicity towards humans and animals. Consequently, the content and distribution of SGAs are crucial traits for the genetic improvement of potatoes. This review focuses on advancing research related to the biochemical properties, biosynthesis, regulatory mechanisms, and genetic improvement of potato SGAs. Furthermore, we provide perspectives on future research directions to further enhance our understanding of SGA biosynthesis and regulation, ultimately facilitating the targeted development of superior potato varieties.
Barriers and facilitators to programmatic mass drug administration in persistent schistosomiasis hotspot communities: An ethnographic study along Lake Albert, midwestern Uganda
Authors: Odoi Paskari , Neema Stella , Vennervald Birgitte J. , Tukahebwa Edridah M. , Wilson Shona 
Published: December 2024

Background
The WHO Neglected Tropical Disease Roadmap for 2021–2030 includes the goal of eliminating schistosomiasis as a public health problem in all endemic countries. Despite heightened efforts since 2012, critical action is still required in addressing barriers to Mass Drug Administration, the primary control method. This includes improvement in adherence by the populations in persistent schistosomiasis hotspots. One such hotspot is the shoreline of Lake Albert, Uganda, where schistosomiasis control is provided to school-aged children and adults. An overemphasis on regular treatment, without comprehensively addressing factors that result in low uptake of treatment in these high-risk populations is likely to impact the elimination of schistosomiasis as a public health problem.

Methods
An ethnographic study using in-depth interviews, key informant interviews, focus group discussions and participant observation was conducted at two study sites along Lake Albert. Thematic content analysis was used during data analysis.

Results
The study revealed that the size, taste and smell of the drug, along with its side-effects; poor community integration and occupational behaviour resulting in non-mobilisation; and unfounded rumours and beliefs remain reasons for persistent low uptake of praziquantel by some. Conversely, lived experience of improved health through participation and knowledge of the dangers of the disease if not treated, facilitated treatment uptake. Positive attitudes to localised sensitisation by community drug distributors show social influence facilitates crucial knowledge attainment. Treatment uptake is further facilitated by the delivery of the drug at no cost at home. Crucially, for the majority of participants the facilitating factors were found to outweigh the inhibitory factors related to the drug’s side effects.

Conclusion
We recommend a good community engagement strategy that provides continuous education and sensitisation, with improved recruitment and training provision for Community Drug Distributors to facilitate programme reach to groups with current poor engagement.
Relevance of reporting leprosy related disability at the completion of multi drug therapy: A 5-year retrospective analysis of disability in persons affected by leprosy at ALERT Hospital Ethiopia
Authors: Tegene Bereket Abebayehu , Atnafu Thomas Asfaw 
Published: December 2024

Background
Leprosy is one of the neglected tropical diseases associated with significant morbidity in endemic regions. It causes disability affecting the daily activities and social participation of affected individuals. Understanding the prevalence and trend of leprosy-related disability throughout the world and the accuracy of disability data counted by WHO is crucial in guiding efforts to be made towards the targets set by WHO to be achieved by 2030. This study aims to show the significance of reporting leprosy-related disability at the end of MDT and critique how disability is counted in the context of WHO data.

Methods
This is a mixed method study with a 5-year retrospective analysis of outcomes of newly diagnosed leprosy patients at ALERT Hospital in Ethiopia from 2016 to 2020. A comparative review and analysis of leprosy related G2D (Grade 2 Disability), globally, regionally, and in Ethiopia using WHO data was also done. In addition, semi-structured interview of health workers (HCWs) and professionals working in the field of leprosy at various organizations was conducted.

Results
The trend of G2D among newly diagnosed leprosy patients shows no decline globally for the past 20 years. It is increasing in Africa and stable in the Southeast Asian and American regions where majority of leprosy patients are found showing the gap in early case identification and prompt treatment of leprosy cases. The total number of newly diagnosed leprosy cases at ALERT hospital between January 2016 and December 2020 were 1032 and among those patients who had completed treatment the prevalence of G2D was 33% at diagnosis and 23% at completion. The interview has also shown gaps in the completeness and quality of disability data reported to WHO and how disability is counted.

Conclusion
Leprosy related G2D among newly diagnosed patient is not declining worldwide and even increasing in endemic regions like Ethiopia. More training should be given to health professionals in assessing disability. WHO should make some changes in the way it counts disability as the current definitions are prone to interpretation bias and lacks uniformity among various programmes and health workers. Prospective studies are needed in assessing disability progression post MDT so as design interventions and strategies in preventing worsening of disability after patients are discharged from treatment centre.
A supervised machine learning statistical design of experiment approach to modeling the barriers to effective snakebite treatment in Ghana
Authors: Nyarko Eric , Agyemang Edmund Fosu , Ameho Ebenezer Kwesi , Agyekum Louis , Gutiérrez José María , Fernandez Eduardo Alberto 
Published: December 2024

Background
Snakebite envenoming is a serious condition that affects 2.5 million people and causes 81,000–138,000 deaths every year, particularly in tropical and subtropical regions. The World Health Organization has set a goal to halve the deaths and disabilities related to snakebite envenoming by 2030. However, significant challenges in achieving this goal include a lack of robust research evidence related to snakebite incidence and treatment, particularly in sub-Saharan Africa. This study aimed to combine established methodologies with the latest tools in Artificial Intelligence to assess the barriers to effective snakebite treatment in Ghana.

Method
We used a MaxDiff statistical experiment design to collect data, and six supervised machine learning models were applied to predict responses whose performance showed an advantage over the other through 6921 data points partitioned using the hold-back validation method, with 70% training and 30% validation. The results were compared using key metrics: Akaike Information Criterion corrected, Bayesian Information Criterion, Root Average Squared Error, and Fit Time in milliseconds.

Results
Considering all the responses, none of the six machine learning algorithms proved superior, but the Generalized Regression Model (Ridge) performed consistently better among the candidate models. The model consistently predicted several key significant barriers to effective snakebite treatment, such as the high cost of antivenoms, increased use of unorthodox, harmful practices, lack of access to effective antivenoms in remote areas when needed, and resorting to unorthodox and harmful practices in addition to hospital treatment.

Conclusion
The combination of a MaxDiff statistical experiment design to collect data and six machine learning models allowed the identification of barriers to accessing effective therapies for snakebite envenoming in Ghana. Addressing these barriers through targeted policy interventions, including intensified advocacy, continuous education, community engagement, healthcare worker training, and strategic investments, can enhance the effectiveness of snakebite treatment, ultimately benefiting snakebite victims and reducing the burden of snakebite envenoming. There is a need for robust regulatory frameworks and increased antivenom production to address these barriers.
Identification of druggable targets from the interactome of the Androgen Receptor and Serum Response Factor pathways in prostate cancer
Authors: Azam Haleema , Veale Colin , Zitzmann Kim , Marcone Simone , Gallagher William M. , Prencipe Maria 
Published: December 2024

Background
The Androgen Receptor (AR) pathway is crucial in driving the progression of prostate cancer (PCa) to an advanced state. Despite the introduction of second-generation AR antagonists, such as enzalutamide, majority of patients develop resistance. Several mechanisms of resistance have been identified, including the constitutive activation of the AR pathway, the emergence of AR spliced variants, and the influence of other signalling pathways. The Serum Response Factor (SRF) was previously identified as a possible player of resistance involved in a crosstalk with the AR signalling pathway. Elevated SRF levels in PCa patients were associated with disease progression and resistance to enzalutamide. However, the molecular mediators of the crosstalk between SRF and AR still need to be elucidated. The objective of this study was to identify common interactors of the AR/SRF crosstalk as therapeutic targets.

Methods
Here we used affinity purification mass spectrometry (MS) following immunoprecipitation of SRF and AR, to identify proteins that interact with both SRF and AR. The list of common interactors was expanded using STRING. Four common interactors were functionally validated using MTT assays.

Results
Seven common interactors were identified, including HSP70, HSP0AA1, HSP90AB1, HSAP5, PRDX1 and GAPDH. Pathway analysis revealed that the PI3k/AKT pathway was the most enriched in the AR/SRF network. Moreover, pharmacological inhibition of several proteins in this network, including HSP70, HSP90, PI3k and AKT, significantly decreased cellular viability of PCa cells.

Conclusions
This study identified a list of AR/SRF common interactors that represent a pipeline of druggable targets for the treatment of PCa.