bluuebunny/crossref_metadata_2025_split huggingface dataset:
FIDO‐SIT: The First Forward Model for the In Situ Magnetic Field of CME‐Driven Sheaths
Authors: Kay C. , Nieves‐Chinchilla T. , Jian L. K. 
Published: February 2020

AbstractWe have shown previously that the in situ magnetic field of coronal mass ejections (CMEs) can be well reproduced by simple, physics‐driven flux rope models using the ForeCAT In situ Data Observer (FIDO, Kay et al., 2017). Here, we show that a similar approach can be taken to forward model the shock and sheath of a CME (Sheath Induced by Transient [SIT]). We develop a relation between the downstream density and magnetic field strength that only depends on the upstream properties and downstream speed. Next, we establish a set of well‐observed CME‐driven shocks combining results from several online catalogs. We establish a baseline using the observed downstream speed and show that the mean absolute errors only increase slightly to 3.4 cm
and 3.8 nT when using a predicted downstream velocity. We also develop a model for the sheath duration or the standoff distance of the CME‐driven shock. While there is certainly room for improvement, our model does perform better than those currently available, reducing the error from 7.0 to 4.6 hr. We couple our flux rope and sheath models as FIDO‐SIT and present results for four observed cases. For three of the four cases, FIDO‐SIT reproduces the sheath magnetic field with an error of one third the total magnitude for each individual vector component.
Paleomagnetism of Middle Triassic Lavas From Northern Qiangtang (Tibet): Constraints on the Closure of the Paleo‐Tethys Ocean
Authors: Song Peiping , Ding Lin , Lippert Peter C. , Li Zhenyu , Zhang Liyun , Xie Jing 
Published: February 2020

AbstractWe present results from a paleomagnetic study of Middle Triassic lavas (~242–240 Ma) from the northern Qiangtang block to improve our understanding of the timing and kinematics of the closure of the eastern Paleo‐Tethys Ocean. Characteristic remanent magnetization directions carried by magnetite and hematite formed during high‐temperature oxidation during initial cooling of the lavas are successfully isolated by progressive thermal and alternating field demagnetizations. We bin 28 site mean directions into 20 independent direction groups that pass the fold test, average secular variation, and show no rock magnetic or petrographic evidence of weathering. These data establish the first lava‐based paleomagnetic pole of Middle Triassic age for the northern Qiangtang block (62.2°N, 196.4°E, A95 = 5.6°). We compare this pole to coeval poles from the North China Block and Tarim and estimate that the remnant Paleo‐Tethys or Hoh‐Xil‐Songpan‐Ganzi Ocean could have been up to 700 km at ~240 Ma. A comparison of the Triassic latitudinal history between the northern Qiangtang block and the North China Block and Tarim shows that the closure of the Paleo‐Tethys Ocean most likely occurred during the latest Triassic. Our review of published Permian‐Triassic poles from the northern Qiangtang block show that the average south‐north plate velocity of the terrane decelerated from ~8.5 cm/yr during ~300–240 Ma to ~3.6 cm/yr during ~240–210 Ma. We suggest that an arc‐continent collision between the northern Qiangtang block and a Paleo‐Tethys or Yidun arc around or before 240 Ma contributed to this change in plate velocity.
Quantifying Postrift Lower Crustal Flow in the Northern Margin of the South China Sea
Authors: Dong Miao , Zhang Jian , Brune Sascha , Wu Shiguo , Fang Gui , Yu Lei 
Published: February 2020

AbstractPostrift subsidence of sedimentary basins in the northern margin of the South China Sea exceeds more than 2,.000 m, which points toward anomalous postrift crustal deformation. Previous studies have proposed lower crustal flow to explain this observation; however, this hypothesis has never been confirmed quantitatively. Here, we calculate the initial crustal structure and thermal lithospheric thickness of the northern margin of the South China Sea on the basis of recently measured heat flow data, tectonic subsidence curves, and present‐day crustal structure. Crustal thinning processes during rifting and reduced thickness of the lower crust in the postrift are also calculated by the strain rate inversion method and thermal isostasy. Our results show that the initial (Early Cenozoic) crustal thickness of the northern margin of the South China Sea varies between 27.7 and 36.3 km, and the average proportion of the lower crust is 67%. The initial thermal lithospheric thicknesses decrease from ~118 to ~81 km from the shelf to the sea, which indicates that the offshore margin has high temperatures and low strength and is more easily stretched and deformed. The average stretching factor the margin during rifting is 1.24. The lower crust reduces in thickness during the postrift phase by values between 1 and 11 km, which increases gradually from the shelf to deep water. We suggest that the thicker weak crust and hot lithospheric structure therefore make positive contribution to the lower crustal flow, the direction of which is from the oceanic basin to the shelf.
Near‐Future Anthropogenic Aerosol Emission Scenarios and Their Direct Radiative Effects on the Present‐Day Characteristics of the Indian Summer Monsoon
Authors: Das Sushant , Giorgi Filippo , Giuliani Graziano , Dey Sagnik , Coppola Erika 
Published: February 2020

AbstractVarious air pollution mitigation scenarios have been proposed to improve the existing severe air quality problem over South Asia. Here we use a regional climate model to examine the response of the Indian summer monsoon (ISM) to two projected anthropogenic aerosol emission scenarios (a) short‐lived climate pollutant “mitigation” scenario (2020–2030) and (b) current legislation “baseline” scenario (2005–2015). In the mitigation scenario, carbonaceous aerosol (black carbon and organic carbon) emissions are projected to decrease while sulfate emissions are projected to increase. This is expected to result in a marginal increase in anthropogenic aerosol optical depth over India (by 0.04–0.08). The dominating effect of scattering aerosols over absorbing aerosols in the mitigation scenario is expected to enhance atmospheric cooling over the Indian landmass, which in turn dampens the latitudinal thermal gradient and leads to a weakening of the ISM. This effect also reduces dust emissions over the Arabian Peninsula and transport across the Arabian Sea, decreasing the influence of the dust radiative feedback on the ISM. In addition, the increased amounts of sulfate and decreased amounts of carbonaceous aerosols are expected to result in drier conditions over the central parts of India. We also show that changes in emissions of different types of anthropogenic aerosols induce a chain of feedbacks, which can modulate the space‐time variability of dust, thereby affecting the magnitude of dust radiative effects on the ISM dynamics. We conclude that it is critical from the policy point of view to implement strategies to cut the currently increasing sulfate emissions.
Improvement of the Irrigation Scheme in the ORCHIDEE Land Surface Model and Impacts of Irrigation on Regional Water Budgets Over China
Authors: Yin Z. , Wang X. H. , Ottlé C. , Zhou F. , Guimberteau M. , Polcher J. , Peng S. S. , Piao S. L. , Li L. , Bo Y. , Chen X. L. , Zhou X. D. , Kim H. , Ciais P. 
Published: February 2020

AbstractIn China, irrigation is widespread in 40.7% cropland to sustain crop yields. By its action on water cycle, irrigation affects water resources and local climate. In this study, a new irrigation module, including flood and paddy irrigation technologies, was developed in the ORCHIDEE‐CROP land surface model which describes crop phenology and growth in order to estimate irrigation demands over China from 1982 to 2014. Three simulations were performed including NI (no irrigation), IR (with irrigation limited by local water resources), and FI (with irrigation demand fulfilled). Observations and census data were used to validate the simulations. Results showed that the estimated irrigation water withdrawal (
) based on IR and FI scenarios bracket statistical
with fair spatial agreements (
;
). Improving irrigation efficiency was found to be the dominant factor leading to the observed
decrease. By comparing simulated total water storage (TWS) with GRACE observations, we found that simulated TWS with irrigation well explained the TWS variation over China. However, our simulation overestimated the seasonality of TWS in the Yangtze River Basin due to ignoring regulation of artificial reservoirs. The observed TWS decrease in the Yellow River Basin caused by groundwater depletion was not totally captured in our simulation, but it can be inferred by combining simulated TWS with census data. Moreover, we demonstrated that land use change tended to drive
locally but had little effect on total
over China due to water resources limitation.
Inducible expression of Wnt7b promotes bone formation in aged mice and enhances fracture healing
Authors: Song Deye , He Guangxu , Song Fangfang , Wang Zhepeng , Liu Xiaochen , Liao Lele , Ni Jiangdong , Silva Matthew J. , Long Fanxin 
Published: February 2020

AbstractThere remain unmet clinical needs for safe and effective bone anabolic therapies to treat aging-related osteoporosis and to improve fracture healing in cases of nonunion or delayed union. Wnt signaling has emerged as a promising target pathway for developing novel bone anabolic drugs. Although neutralizing antibodies against the Wnt antagonist sclerostin have been tested, Wnt ligands themselves have not been fully explored as a potential therapy. Previous work has demonstrated Wnt7b as an endogenous ligand upregulated during osteoblast differentiation, and that Wnt7b overexpression potently stimulates bone accrual in the mouse. The earlier studies however did not address whether Wnt7b could promote bone formation when specifically applied to aged or fractured bones. Here we have developed a doxycycline-inducible strategy where Wnt7b is temporally induced in the bones of aged mice or during fracture healing. We report that forced expression of Wnt7b for 1 month starting at 15 months of age greatly stimulated trabecular and endosteal bone formation, resulting in a marked increase in bone mass. We further tested the effect of Wnt7b on bone healing in a murine closed femur fracture model. Induced expression of Wnt7b at the onset of fracture did not affect the initial cartilage formation but promoted mineralization of the subsequent bone callus. Thus, targeted delivery of Wnt7b to aged bones or fracture sites may be explored as a potential therapy.
MARCH5-dependent degradation of MCL1/NOXA complexes defines susceptibility to antimitotic drug treatment
Authors: Haschka Manuel D. , Karbon Gerlinde , Soratroi Claudia , O’Neill Katelyn L. , Luo Xu , Villunger Andreas 
Published: February 2020

AbstractCells experiencing delays in mitotic progression are prone to undergo apoptosis unless they can exit mitosis before proapoptotic factors reach a critical threshold. Microtubule targeting agents (MTAs) arrest cells in mitosis and induce apoptotic cell death engaging the BCL2 network. Degradation of the antiapoptotic BCL2 family member MCL-1 is considered to set the time until onset of apoptosis upon MTA treatment. MCL1 degradation involves its interaction with one of its key binding partners, the proapoptotic BH3-only protein NOXA. Here, we report that the mitochondria-associated E3-ligase MARCH5, best known for its role in mitochondrial quality control and regulation of components of the mitochondrial fission machinery, controls the levels of MCL1/NOXA protein complexes in steady state as well as during mitotic arrest. Inhibition of MARCH5 function sensitizes cancer cells to the proapoptotic effects of MTAs by the accumulation of NOXA and primes cancer cells that may undergo slippage to escape death in mitosis to cell death in the next G1 phase. We propose that inhibition of MARCH5 may be a suitable strategy to sensitize cancer cells to antimitotic drug treatment.
Erythropoietin and its derivatives: from tissue protection to immune regulation
Authors: Peng Bo , Kong Gangcheng , Yang Cheng , Ming Yingzi 
Published: February 2020

AbstractErythropoietin (EPO) is an evolutionarily conserved hormone well documented for its erythropoietic role via binding the homodimeric EPO receptor (EPOR)2. In past decades, evidence has proved that EPO acts far beyond erythropoiesis. By binding the tissue-protective receptor (TPR), EPO suppresses proinflammatory cytokines, protects cells from apoptosis and promotes wound healing. Very recently, new data revealed that TPR is widely expressed on a variety of immune cells, and EPO could directly modulate their activation, differentiation and function. Notably, nonerythropoietic EPO derivatives, which mimic the structure of helix B within EPO, specifically bind TPR and show great potency in tissue protection and immune regulation. These small peptides prevent the cardiovascular side effects of EPO and are promising as clinical drugs. This review briefly introduces the receptors and tissue-protective effects of EPO and its derivatives and highlights their immunomodulatory functions and application prospects.
Ferroptosis: past, present and future
Authors: Li Jie , Cao Feng , Yin He-liang , Huang Zi-jian , Lin Zhi-tao , Mao Ning , Sun Bei , Wang Gang 
Published: February 2020

AbstractFerroptosis is a new type of cell death that was discovered in recent years and is usually accompanied by a large amount of iron accumulation and lipid peroxidation during the cell death process; the occurrence of ferroptosis is iron-dependent. Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. Recent studies have shown that ferroptosis is closely related to the pathophysiological processes of many diseases, such as tumors, nervous system diseases, ischemia-reperfusion injury, kidney injury, and blood diseases. How to intervene in the occurrence and development of related diseases by regulating cell ferroptosis has become a hotspot and focus of etiological research and treatment, but the functional changes and specific molecular mechanisms of ferroptosis still need to be further explored. This paper systematically summarizes the latest progress in ferroptosis research, with a focus on providing references for further understanding of its pathogenesis and for proposing new targets for the treatment of related diseases.
Ferroptosis involves in intestinal epithelial cell death in ulcerative colitis
Authors: Xu Minyi , Tao Jin , Yang Yidong , Tan Siwei , Liu Huiling , Jiang Jie , Zheng Fengping , Wu Bin 
Published: February 2020

AbstractFerroptosis has recently emerged as an iron-dependent form of nonapoptotic cell death, which is also a regulated necrosis process and a response to tumor suppression. However, whether ferroptosis is involved in ulcerative colitis (UC) is unknown. The aims of this study were to investigate whether the ferroptosis is involved in UC, particularly intestinal epithelial cell (IEC) death, and to analyze the effect of the nuclear factor kappa Bp65 subunit (NF-κBp65) on ferroptosis. The gene expression of ferroptosis-related proteins was assessed in intestinal mucosal samples from human UC. The experimental model of UC was induced with dextran sulfate sodium (DSS). Ferroptosis of IECs was evaluated, the effect of NF-κBp65 on ferroptosis was analyzed by using IEC-specific NF-κBp65-deleted mice (p65IEC-KO), and the ferroptosis signaling pathway was investigated in vitro and in vivo. The results showed that ferroptosis was significantly induced in the IECs from UC patients and mice with colitis, and the ferroptosis was mediated by endoplasmic reticulum (ER) stress signaling. The specific deletion of IEC NF-κBp65 clearly upregulated ferroptosis and exacerbated colitis, and the result showed that phosphorylated-NF-κBp65 significantly inhibited ER stress signaling by directly binding eukaryotic initiation factor 2α. These data indicate that ferroptosis contributes to UC via ER stress-mediated IEC cell death, and that NF-κBp65 phosphorylation suppresses ER stress-mediated IEC ferroptosis to alleviate UC. The results suggest that ferroptosis involves in IEC death in UC, NF-κBp65 play a critical role in the ferroptotic inhibition, and ferroptosis is a potential therapeutic target for UC.
A rare gain of function mutation in a wheat tandem kinase confers resistance to powdery mildew
Authors: Lu Ping , Guo Li , Wang Zhenzhong , Li Beibei , Li Jing , Li Yahui , Qiu Dan , Shi Wenqi , Yang Lijun , Wang Ning , Guo Guanghao , Xie Jingzhong , Wu Qiuhong , Chen Yongxing , Li Miaomiao , Zhang Huaizhi , Dong Lingli , Zhang Panpan , Zhu Keyu , Yu Dazhao , Zhang Yan , Deal Karin R. , Huo Naxin , Liu Cuimin , Luo Ming-Cheng , Dvorak Jan , Gu Yong Qiang , Li Hongjie , Liu Zhiyong 
Published: February 2020

AbstractPowdery mildew, caused by Blumeria graminis f. sp. tritici (Bgt), is one of the most destructive diseases that pose a great threat to wheat production. Wheat landraces represent a rich source of powdery mildew resistance. Here, we report the map-based cloning of powdery mildew resistance gene Pm24 from Chinese wheat landrace Hulutou. It encodes a tandem kinase protein (TKP) with putative kinase-pseudokinase domains, designated WHEAT TANDEM KINASE 3 (WTK3). The resistance function of Pm24 was validated by transgenic assay, independent mutants, and allelic association analyses. Haplotype analysis revealed that a rare 6-bp natural deletion of lysine-glycine codons, endemic to wheat landraces of Shaanxi Province, China, in the kinase I domain (Kin I) of WTK3 is critical for the resistance function. Transgenic assay of WTK3 chimeric variants revealed that only the specific two amino acid deletion, rather than any of the single or more amino acid deletions, in the Kin I of WTK3 is responsible for gaining the resistance function of WTK3 against the Bgt fungus.
Familial/inherited cancer syndrome: a focus on the highly consanguineous Arab population
Authors: AlHarthi Fawz S. , Qari Alya , Edress Alaa , Abedalthagafi Malak 
Published: February 2020

AbstractThe study of hereditary cancer, which accounts for ~10% of cancer cases worldwide is an important subfield of oncology. Our understanding of hereditary cancers has greatly advanced with recent advances in sequencing technology, but as with any genetic trait, gene frequencies of cancer-associated mutations vary across populations, and most studies that have located hereditary cancer genes have been conducted on European or Asian populations. There is an urgent need to trace hereditary cancer genes across the Arab world. Hereditary disease is particularly prevalent among members of consanguineous populations, and consanguineous marriages are particularly common in the Arab world. There are also cultural and educational idiosyncrasies that differentiate Arab populations from other more thoroughly studied groups with respect to cancer awareness and treatment. Therefore, a review of the literature on hereditary cancers in this understudied population was undertaken. We report that BRCA mutations are not as prevalent among Arab breast cancer patients as they are among other ethnic groups, and therefore, other genes may play a more important role. A wide variety of germline inherited mutations that are associated with cancer are discussed, with particular attention to breast, ovarian, colorectal, prostate, and brain cancers. Finally, we describe the state of the profession of familial cancer genetic counselling in the Arab world, and the clinics and societies dedicated to its advances. We describe the complexities of genetic counselling that are specific to the Arab world. Understanding hereditary cancer is heavily dependent on understanding population-specific variations in cancer-associated gene frequencies.
Clozapine-induced transcriptional changes in the zebrafish brain
Authors: Viana Joana , Wildman Nick , Hannon Eilis , Farbos Audrey , Neill Paul O’ , Moore Karen , van Aerle Ronny , Paull Greg , Santos Eduarda , Mill Jonathan 
Published: February 2020

AbstractClozapine is an atypical antipsychotic medication that is used to treat schizophrenia patients who are resistant to other antipsychotic drugs. The molecular mechanisms mediating the effects of clozapine are not well understood and its use is often associated with severe side-effects. In this study, we exposed groups of wild-type zebrafish to two doses of clozapine (‘low’ (20 µg/L) and ‘high’ (70 µg/L)) over a 72-h period, observing dose-dependent effects on behaviour. Using RNA sequencing (RNA-seq) we identified multiple genes differentially expressed in the zebrafish brain following exposure to clozapine. Network analysis identified co-expression modules characterised by striking changes in module connectivity in response to clozapine, and these were enriched for regulatory pathways relevant to the etiology of schizophrenia. Our study highlights the utility of zebrafish as a model for assessing the molecular consequences of antipsychotic medications and identifies genomic networks potentially involved in schizophrenia.
Physical and chemical descriptors for predicting interfacial thermal resistance
Authors: Wu Yen-Ju , Zhan Tianzhuo , Hou Zhufeng , Fang Lei , Xu Yibin 
Published: February 2020

AbstractHeat transfer at interfaces plays a critical role in material design and device performance. Higher interfacial thermal resistances (ITRs) affect the device efficiency and increase the energy consumption. Conversely, higher ITRs can enhance the figure of merit of thermoelectric materials by achieving ultra-low thermal conductivity via nanostructuring. This study proposes a dataset of descriptors for predicting the ITRs. The dataset includes two parts: one part consists of ITRs data collected from 87 experimental papers and the other part consists of the descriptors of 289 materials, which can construct over 80,000 pair-material systems for ITRs prediction. The former part is composed of over 1300 data points of metal/nonmetal, nonmetal/nonmetal, and metal/metal interfaces. The latter part consists of physical and chemical properties that are highly correlated to the ITRs. The synthesis method of the materials and the thermal measurement technique are also recorded in the dataset for further analyses. These datasets can be applied not only to ITRs predictions but also to thermal-property predictions or heat transfer on various material systems.