bluuebunny/crossref_metadata_2025_split huggingface dataset:
Access to maternal healthcare services among Indigenous women in the Chittagong Hill Tracts, Bangladesh: A cross-sectional study
Authors: Akter Shahinoor , Rich Jane Louise , Davies Kate , Inder Kerry Jill 
Published: October 2019

ObjectivesThis study aimed to estimate the prevalence of, and factors associated with, accessing maternal healthcare services (MHC) by Indigenous women in the Chittagong Hill Tracts (CHT), Bangladesh.DesignThis was a cross-sectional survey among Indigenous women of reproductive age.SettingTwo upazillas (subdistricts) of Khagrachhari hill district of the CHT.ParticipantsIndigenous women (15–49 years) within 36 months of delivery were surveyed about accessing MHC services (antenatal care, delivery and postnatal care) for their last pregnancy and delivery.Primary outcome measuresThe primary outcome for this analysis is the prevalence of accessing any MHC service and secondary outcome is factors associated with access to MHC services for Indigenous women during their last pregnancy and childbirth.ResultsOf 438 Indigenous women (220 Chakma, 100 Marma, 118 Tripura) who participated, 75% were aged 16–30 years. With an 89% response rate, a total of 258 (59%) women reported accessing at least one MHC service (Chakma 51.6%, Marma 28%, Tripura 20.5%; p=<0.001). Independent factors associated with accessing MHC after adjusting for clustering were attending secondary school and above (OR 2.4; 95% CI 1.2 to 4.9); knowledge about nearest health facilities (OR 3.8, 95% CI 1.8 to 7.8) and knowledge of pregnancy-related complications (OR 3.0, 95% CI 1.5 to 5.8).ConclusionFindings suggest that the prevalence of accessing MHC services is lower among Indigenous women in the CHT compared with national average. MHC access may be improved through better education and awareness raising of local services.
Improving Mood with Physical ACTivity (IMPACT) trial: a cluster randomised controlled trial to determine the effectiveness of a brief physical activity behaviour change intervention on depressive symptoms in young people, compared with psychoeducation, in addition to routine clinical care within youth mental health services—a protocol study
Authors: Parker Alexandra G. , Markulev Connie , Rickwood Debra J. , Mackinnon Andrew , Purcell Rosemary , Alvarez-Jimenez Mario , Yung Alison R. , McGorry Patrick , Hetrick Sarah E. , Jorm Anthony 
Published: October 2019

IntroductionDepression is highly prevalent and the leading contributor to the burden of disease in young people worldwide, making it an ongoing priority for early intervention. As the current evidence-based interventions of medication and psychological therapy are only modestly effective, there is an urgent need for additional treatment strategies. This paper describes the rationale of the Improving Mood with Physical ACTivity (IMPACT) trial. The primary aim of the IMPACT trial is to determine the effectiveness of a physical activity intervention compared with psychoeducation, in addition to routine clinical care, on depressive symptoms in young people. Additional aims are to evaluate the intervention effects on anxiety and functional outcomes and examine whether changes in physical activity mediate improvements in depressive symptoms.Methods and analysisThe study is being conducted in six youth mental health services across Australia and is using a parallel-group, two-arm, cluster randomised controlled trial design, with randomisation occurring at the clinician level. Participants aged between 12 years and 25 years with moderate to severe levels of depression are randomised to receive, in addition to routine clinical care, either: (1) a physical activity behaviour change intervention or (2) psychoeducation about physical activity. The primary outcome will be change in the Quick Inventory of Depressive Symptomatology, with assessments occurring at baseline, postintervention (end-point) and 6-month follow-up from end-point. Secondary outcome measures will address additional clinical outcomes, functioning and quality of life. IMPACT is to be conducted between May 2014 and December 2019.Ethics and disseminationEthical approval was obtained from the University of Melbourne Human Research Ethics Committee on 8 June 2014 (HREC 1442228). Trial findings will be published in peer-reviewed journals and presented at conferences. Key messages will also be disseminated by the youth mental health services organisation (headspace National Youth Mental Health Foundation).Trial registration numberACTRN12614000772640.
Validity of estimating physical activity intensity using a triaxial accelerometer in healthy adults and older adults
Authors: Nagayoshi Sho , Oshima Yoshitake , Ando Takafumi , Aoyama Tomoko , Nakae Satoshi , Usui Chiyoko , Kumagai Shuzo , Tanaka Shigeho 
Published: October 2019

BackgroundA triaxial accelerometer with an algorithm that could discriminate locomotive and non-locomotive activities in adults has been developed. However, in the elderly, this accelerometer has not yet been validated. The aim were to examine the validity of this accelerometer in the healthy elderly, and to compare the results with those derived in a healthy younger sample.MethodsTwenty-nine healthy elderly subjects aged 60–80 years (Elderly), and 42 adults aged 20–59 years (Younger) participated. All subjects performed 11 activities, including locomotive and non-locomotive activities with a Douglas bag while wearing the accelerometer (Active style Pro HJA-750C). Physical activity intensities were expressed as metabolic equivalents (METs). The relationship between the METs measured using the Douglas bag and METs predicted using the accelerometer was evaluated.ResultsA significant correlation between actual and predicted METs was observed in both Elderly (r=0.85, p<0.001) and Younger (r=0.88, p<0.001). Predicted METs significantly underestimated compared with actual METs in both groups (p<0.001). The mean of the errors was −0.6±0.6 METs in Elderly and −0.1±0.5 METs in Younger. The degree of underestimation increased with increasing METs in Elderly (p<0.001). A stepwise multiple regression analysis revealed that predicted METs, age, and weight were related to actual METs in both groups.ConclusionThe degree of correlation between predicted and actual METs was comparable in elderly and younger participants, but the prediction errors were greater in elderly participants, particular at higher-intensity activities, which suggests that different predicting equations may be needed for the elderly.
Mesothelioma mortality in Great Britain: how much longer will dockyards dominate?
Authors: Reynolds Carl J , Minelli Cosetta , Darnton Andrew , Cullinan Paul 
Published: October 2019

ObjectivesWe aimed to investigate whether there has been a geographic shift in the distribution of mesothelioma deaths in Great Britain given the decline of shipbuilding and progressive exposure regulation.MethodsWe calculated age-adjusted mesothelioma mortality rates and estimated rate ratios for areas with and without a dockyard. We compared spatial autocorrelation statistics (Moran’s I) for age-adjusted rates at local authority district level for 2002–2008 and 2009–2015. We measured the mean distance of the deceased’s postcode to the nearest dockyard at district level and calculated the association of average distance to dockyard and district mesothelioma mortality using simple linear regression for men, for 2002–2008 and 2009–2015.ResultsDistrict age-adjusted male mortality rates fell during 2002–2015 for 80 of 348 districts (23%), rose for 267 (77%) and were unchanged for one district; having one or more dockyards in a district was associated with rates falling (OR=2.43, 95% CI 1.22 to 4.82, p=0.02). The mortality rate ratio for men in districts with a dockyard, compared with those without a dockyard was 1.41 (95% CI 1.35 to 1.48, p<0.05) for 2002–2008 and 1.18 (95% CI 1.13 to 1.23, p<0.05) for 2009–2015. Spatial autocorrelation (measured by Moran’s I) decreased from 0.317 (95% CI 0.316 to 0.319, p=0.001) to 0.312 (95% CI 0.310 to 0.314, p=0.001) for men and the coefficient of the association between distance to dockyard and district level age-adjusted male mortality (per million population) from −0.16 (95% CI −0.21 to −0.10, p<0.01) to −0.13 (95% CI −0.18 to −0.07, p<0.01) for men, when comparing 2002–2008 with 2009–2015.ConclusionFor most districts age-adjusted mesothelioma mortality rates increased through 2002–2015 but the relative contribution from districts with a dockyard fell. Dockyards remain strongly spatially associated with mesothelioma mortality but the strength of this association appears to be falling and mesothelioma deaths are becoming more dispersed.
The utility of impedance cardiography in hemodynamic monitoring of patients with sepsis
Authors: Butz James , Shan Yizhi , Samayoa Andres , Kirton Orlando C , Vu Thai 
Published: October 2019

BackgroundCommonly used biochemical indicators and hemodynamic and physiologic parameters of sepsis vary with regard to their sensitivity and specificity to the diagnosis. The aim of this preliminary study was to evaluate non-invasive impedance cardiography as a monitoring tool of the hemodynamic status of patients with sepsis throughout their initial volume resuscitation to explore the possibility of identifying additional measurements to be used in the future treatment of sepsis.MethodsNine patients who presented to the emergency room and received a surgical consultation during a 3-month period in 2016, meeting the clinical criteria of sepsis defined by systemic inflammatory response syndrome in the 2012 Surviving Sepsis Campaign Guidelines, were included in this study. We applied cardiac impedance monitors to each patient’s anterior chest and neck and obtained baseline recordings. Measurements were taken at activation of the sepsis alert and 1 hour after fluid resuscitation with 2 L of intravenous crystalloid solution.ResultsNine patients met the inclusion criteria. The mean age was 60±17 years and two were female; eight were febrile, five were hypotensive, four were tachycardic, seven were treated for infection, and six had positive blood cultures. Hemodynamic parameters at presentation and 1 hour after fluid resuscitation were heart rate (beats per minute) (97±13 and 93±18; p=0.23), mean arterial pressure (mm Hg) (81±13 and 85±14; p=0.55), systemic vascular resistance (dyne-s/cm−5) (861±162 and 1087±272; p=0.04), afterload measured as systemic vascular resistance index (dyne-s/cm−5/m2) (1813±278 and 2283±497; p=0.04), and left cardiac work index (kg*m/m2) (3.6±1.4 and 3.3±1.3; p=0.69).DiscussionThrough measuring a patient’s systemic vascular resistance and systemic vascular resistance index (afterload), statistical significance is achieved after intervention with a 2 L crystalloid bolus. This suggests that, along with clinical presentation and biochemical markers, impedance cardiography may show utility in providing supporting hemodynamic data to trend resuscitative efforts in patients with sepsis.Level of evidenceLevel IV.
To report, or not to report, animal abuse: the role of perceived self‐efficacy in veterinarians’ decision‐making
Authors: Alleyne Emma , Sienauskaite Ornela , Ford Jade 
Published: October 2019

BackgroundVeterinarians are on the frontline of animal welfare, but little is known about the factors that facilitate their decision to report cases of abuse to authorities. Using perceived self‐efficacy as a basis, the primary aim of this study was to examine the psychological and experiential factors linked to veterinarians’ reporting behaviour.MethodsWe administered questionnaires to 176 veterinarians assessing the amount of training received on detecting/reporting animal abuse, perceived self‐efficacy to report animal abuse, and whether they have reported animal abuse incidents to the relevant authorities.ResultsWe found that perceived self‐efficacy positively correlated with suspecting and reporting animal abuse, number of hours of specialised training, and years working in practice. As hypothesised, we also found that perceived self‐efficacy explained the relationship between specialised training (in hours) and reporting animal abuse.ConclusionsThese findings highlight the psychological impact of specialised training on veterinarians’ reporting behaviour. Simply put, specialist training equips veterinarians with the confidence and self‐efficacy to report suspected cases of animal abuse. The implications for training curriculum and veterinary policy are discussed.
Contrast‐enhanced ultrasound features of hepatocellular carcinoma in dogs
Authors: Banzato Tommaso , Rubini Giuseppe , Orlandi Riccardo , Bargellini Paolo , Bonsembiante Federico , Zotti Alessandro 
Published: October 2019

BackgroundThis study aimed to describe the contrast‐enhanced ultrasound (CEUS) features of canine hepatocellular carcinoma (HCC) in relation to cellular differentiation and lesion size.MethodsSixty dogs with a cytological diagnosis of HCC and that underwent a CEUS examination were retrospectively selected. The wash‐in and wash‐out patterns of contrast enhancement, along with the time to wash‐in and the time to wash‐out, of each lesion were recorded. A dimensional cut‐off value of 3 cm was adopted for classification.ResultsCellular differentiation had a significant influence on both wash‐in (chi‐squared=16.99; P<0.001) and wash‐out (chi‐squared=10.9; P=0.004) patterns of contrast enhancement. Lesion size had a lower, but still significant, influence on both wash‐in (chi‐squared=12.7; P=0.005) and wash‐out (chi‐squared=7.42; P=0.024) patterns. A homogeneous hyperenhancement in the arterial phase followed by homogeneous wash‐out were suggestive of a well‐differentiated HCC. The cellular differentiation of lesions with inhomogeneous hyperenhancement or hypoenhancement/no enhancement as well as an inhomogeneous wash‐out or no wash‐out could not be inferred.ConclusionsNo significant difference in the time to wash‐in and the time to wash‐out in relation to cellular differentiation or lesion size was evident. CEUS has the potential to improve efficiency in the diagnosis of HCCs in dogs.
Brain-derived neurotrophic factor is associated with human muscle satellite cell differentiation in response to muscle-damaging exercise
Authors: McKay Bryon R. , Nederveen Joshua P. , Fortino Stephen A. , Snijders Tim , Joanisse Sophie , Kumbhare Dinesh A. , Parise Gianni 
Published: October 2019

Muscle satellite cell (SC) regulation is a complex process involving many key signalling molecules. Recently, the neurotrophin brain-derived neurotropic factor (BDNF) has implicated in SC regulation in animals. To date, little is known regarding the role of BDNF in human SC function in vivo. Twenty-nine males (age, 21 ± 0.5 years) participated in the study. Muscle biopsies from the thigh were obtained prior to a bout of 300 maximal eccentric contractions (Pre), and at 6 h, 24 h, 72 h, and 96 h postexercise. BDNF was not detected in any quiescent (Pax7+/MyoD−) SCs across the time-course. BDNF colocalized to 39% ± 5% of proliferating (Pax7+/MyoD+) cells at Pre, which increased to 84% ± 3% by 96 h (P < 0.05). BDNF was only detected in 13% ± 5% of differentiating (Pax7−/MyoD+) cells at Pre, which increased to 67% ± 4% by 96 h (P < 0.05). The number of myogenin+ cells increased 95% from Pre (1.6 ± 0.2 cells/100 myofibres (MF)) at 24 h (3.1 ± 0.3 cells/100 MF) and remained elevated until 96 h (cells/100 MF), P < 0.05. The proportion of BDNF+/myogenin+ cells was 26% ± 0.3% at Pre, peaking at 24 h (49% ± 3%, P < 0.05) and remained elevated at 96 h (P < 0.05). These data are the first to demonstrate an association between SC proliferation and differentiation and BDNF expression in humans in vivo, with BDNF colocalization to SCs increasing during the later stages of proliferation and early differentiation. Novelty BDNF is associated with SC response to muscle injury. BDNF was not detected in nonactivated (quiescent) SCs. BDNF is associated with late proliferation and early differentiation of SCs in vivo in humans.
Broad-Spectrum Antibacterial Effects of Human Adipose-Derived Stromal Cells
Authors: Monsarrat Paul , Kémoun Philippe , Casteilla Louis , Planat-Bénard Valérie 
Published: October 2019

Introduction. Many pathological conditions may benefit from cell therapy using mesenchymal stromal cells, particularly from adipose tissue (ASCs). Cells may be grafted in an environment with a remnant polymicrobial component. The aim is to investigate the behavior of ASCs when brought in contact with a large panel of bacteria. Materials and Methods. Carboxyfluorescein-labelled bacterial interaction with ASCs was followed by confocal time-lapse microscopy. Costaining with LAMP-1 was also analyzed. Viability of 4 gram-negative and 4 gram-positive bacterial strains after 6 h of coculture with ASCs was assessed by agar colony counting and by flow cytometry using SYTO-62®/propidium iodide (PI) for membrane permeabilization and DiOC6 for depolarization. A murine model of periodontitis was used to assess in vivo antibacterial capacities of ASCs. Results. A significant increase of PI-positive events for all bacterial strains and an increase of the DiOC6 signal were obtained after contact with ASCs. The number of CFU was also significantly decreased for several bacterial strains. 0.4 μm transwell systems illustrated the necessary direct contact to induce maximal bacterial membrane damages. Some bacteria were observed into phagolysosomes, confirming macrophage-like properties of ASCs. In vivo, the bacterial load was significantly lower in the ASC-grafted side compared to the control. Conclusion. Our results highlight for the first time a broad range of antibacterial actions of ASCs, by phagocytosis, secretion of oxygenated free radicals and antibacterial molecules. These data are in line with the development of new therapeutic strategies based on ASC transplantation, appropriated in immune-dysbiotic tissue context such as periodontitis or chronic wounds.
Differed IL-1 Beta Response between Active TB and LTBI Cases by Ex Vivo Stimulation of Human Monocyte-Derived Macrophage with TB-Specific Antigen
Authors: Lee Meng-Rui , Chang Lih-Yu , Chang Chia-Hao , Yan Bo-Shiun , Wang Jann-Yuan , Lin Wan-Hsin 
Published: October 2019

Background. The difference of macrophage-specific interleukin-1 beta (IL-1b) response between latent tuberculosis infection (LTBI) and active tuberculosis (TB) remains less studied. Method. We performed this prospective study and recruited active TB patients, contacts with LTBI, and uninfected contacts. The gene and protein expression of human monocyte-derived macrophage (hMDM) after ex vivo stimulation by early secretory antigenic target-6KD (ESAT-6) and tuberculin purified protein derivatives (PPD) was studied by real-time PCR and flow cytometry. The effect of caspase-1 inhibitor was also studied. Result. The IL-1b gene expression after 6 hr ESAT-6 1 μg/ml stimulation was different among active TB patients (n=12), LTBI cases (n=12), and uninfected contacts (n=23) (log fold change: 0.98±1.26 vs. 2.20±0.96 vs. 2.20±0.96, P=0.013). The IL-1b gene expression at 24 hours was higher than that at 6 hours in LTBI cases (n=4) and uninfected contacts (n=6). After 24 hr ESAT-6 1 μg/ml stimulation, the percentage of IL-1b-expressed hMDM was borderline lower in the active TB patients (n=9) than in the LTBI cases (n=10) (14.0±11.2% vs. 31.6±22.5%, P=0.065). Compared with ESAT-6 1 μg/ml stimulation but without the addition of caspase-1 inhibitor (CasI) (55.6±16.3%), the percentage of IL-1b-positive hMDMs decreased after addition of CasI (50 μg/ml CasI: 49.8±18.2%, P=0.078; 100 μg/ml CasI: 46.6±20.8%, P=0.030; 150 μg/ml CasI: 33.7±15.5%, P=0.016). Conclusions. This study revealed that macrophage-specific IL-1b response differed among different stages of Mycobacterium tuberculosis infection. The role of IL-1b and inflammasome in the process of LTBI progressing to active TB warrants further investigation.
Color image steganography in YCbCr space
Authors: Alwan Zena Ahmed , Farhan Hamid Mohammed , Mahdi Siraj Qays 
Published: October 2019

Steganography is a best method for in secret communicating information during the transference of data. Images are an appropriate method that used in steganography can be used to protection the simple bits and pieces. Several systems, this one as color scale images steganography and grayscale images steganography, are used on color and store data in different techniques. These color images can have very big amounts of secret data, by using three main color modules. The different color modules, such as
HSV-(hue, saturation, and value), RGB-(red, green, and blue),
YCbCr-(luminance and chrominance), YUV, YIQ, etc. This paper uses unusual module to hide data: an adaptive procedure that can increase security ranks when hiding a top secret binary image in a RGB color image, which we implement the steganography in the YCbCr module space. We performed Exclusive-OR (XOR) procedures between the binary image and the RGB color image in the YCBCR module space. The converted byte stored in the 8-bit LSB is not the actual bytes; relatively, it is obtained by translation to another module space and applies the XOR procedure. This technique is practical to different groups of images. Moreover, we see that the adaptive technique ensures good results as the peak signal to noise ratio (PSNR) and stands for mean square error (MSE) are good. When the technique is compared with our previous works and other existing techniques, it is shown to be the best in both error and message capability. This technique is easy to model and simple to use and provides perfect security with unauthorized.
Speed profile optimization of an electrified train in Cat Linh-Ha Dong metro line based on pontryagin's maximum principle
Authors: Anh An Thi Hoai Thu , Quyen Nguyen Van , Hai Nguyen Thanh , Lien Nguyen Van , Phuong Vu Hoang 
Published: October 2019

An urban railway is a complex technical system that consumes large amounts of energy, but this means of transportation still has been obtained more and more popularity in densely populated cities because of its features of high-capacity transportation capability, high speed, security, punctuality, lower emission, reduction of traffic congestion. The improved energy consumption and environment are two of the main objectives for future transportation. Electrified trains can meet these objectives by the recuperation and reuse of regenerative braking energy and by the energy - efficient operation. Two methods are to enhance energy efficiency: one is to improve technology (e.g., using energy storage system, reversible or active substations to recuperate regenerative braking energy, replacing traction electric motors by energy-efficient traction system as permanent magnet electrical motors; train's mass reduction by lightweight material mass...); the other is to improve operational procedures (e.g. energy efficient driving including: eco-driving; speed profile optimization; Driving Advice System (DAS); Automatic Train Operation (ATO); traffic management optimization...). Among a lot of above solutions for saving energy, which one is suitable for current conditions of metro lines in Vietnam. The paper proposes the optimization method based on Pontryagin's Maximum Principle (PMP) to find the optimal speed profile for electrified train of Cat Linh-Ha Dong metro line, Vietnam in an effort to minimize the train operation energy consumption.