bluuebunny/crossref_metadata_2025_split huggingface dataset:
First evidence of Ixodiphagus hookeri (Hymenoptera: Encyrtidae) parasitization in Finnish castor bean ticks (Ixodes ricinus)
Authors: Sormunen Jani Jukka , Sippola Ella , Kaunisto Kari Mikael , Vesterinen Eero Juhani , Sääksjärvi Ilari Eerikki 
Published: November 2019

AbstractIxodiphagus hookeri (Hymenoptera: Encyrtidae) is a parasitoid wasp specialized in parasitizing the larvae and nymphs of ticks (Acari: Ixodidae). As parasitized ticks die prior to reproduction, I. hookeri is seen as a prime biological control agent candidate. Despite this, little is known of their occurrence or ecology in northern Europe. The main aim of the current study was to determine whether adult wasps or parasitized ticks can be found from a tick-infested island in southwestern Finland, using field collections and molecular methods. Following the initial discovery of an adult I. hookeri female on Seili Island, we set out to collect further specimens via sweep netting and Malaise trappings between May and October 2017. Furthermore, 1310 Ixodes ricinus (1220 nymphs, 90 adults) collected from the island during 2012–2014 were screened for I. hookeri DNA using qPCR. Whereas no further wasp specimens could be collected via sweep netting or Malaise trappings, I. hookeri DNA was consistently detected in I. ricinus nymphs (annual minimum infection rates in 2012, 2013, and 2014: 2.3, 0.4, and 0.5%, respectively), whereas all adult samples were negative. Although the annually repeated detections of parasitized ticks suggest that the wasp inhabits the island, further field and molecular surveys are needed to more comprehensively determine the status and stability of the population.
Comparison of quantitative flow ratio and fractional flow reserve with myocardial perfusion scintigraphy and cardiovascular magnetic resonance as reference standard. A Dan-NICAD substudy
Authors: Sejr-Hansen Martin , Westra Jelmer , Winther Simon , Tu Shengxian , Nissen Louise , Gormsen Lars , Petersen Steffen E. , Ejlersen June , Isaksen Christin , Bøtker Hans Erik , Bøttcher Morten , Christiansen Evald H. , Holm Niels Ramsing 
Published: November 2019

AbstractQuantitative flow ratio (QFR) and fractional flow reserve (FFR) have not yet been compared head to head with perfusion imaging as reference for myocardial ischemia. We aimed to compare the diagnostic accuracy of QFR and FFR with myocardial perfusion scintigraphy (MPS) or cardiovascular magnetic resonance (CMR) as reference. This study is a predefined post hoc analysis of the Dan-NICAD study (NCT02264717). Patients with suspected coronary artery disease by coronary computed tomography angiography (CCTA) were randomized 1:1 to MPS or CMR and were referred to invasive coronary angiography with FFR and predefined QFR assessment. Paired data with FFR, QFR and MPS or CMR were available for 232 vessels with stenosis in 176 patients. Perfusion defects were detected in 57 vessel territories (25%). For QFR and FFR the diagnostic accuracy was 61% and 57% (p = 0.18) and area under the receiver operating curve was 0.64 vs. 0.58 (p = 0.22). Stenoses with absolute indication for stenting due to diameter stenosis > 90% by visual estimate were not classified as significant by either QFR or MPS/CMR in 21% (7 of 34) of cases. The diagnostic performance of QFR and FFR was similar but modest with MPS or CMR as reference. Comparable performance levels for QFR and FFR are encouraging for this pressure wire-free diagnostic method.
Solidago canadensis as a bioaccumulator and phytoremediator of Pb and Zn
Authors: Bielecka Aleksandra , Królak Elżbieta 
Published: November 2019

AbstractCanadian goldenrod (Solidago canadensisL.) is a plant that grows in a variety of environmental conditions. It shows high capability to spread in various habitats, including fallow lands and brownfield land. The research aimed at analyzing the content of Pb and Zn in the underground (roots, rhizomes) and aboveground parts (stems, leaves, inflorences) ofSolidago canadensis(SC) originating from two locations that are clearly different in terms of metal content in soil. Statistically significant differences were determined in the content of Pb and Zn in soil and particular morphological parts of the plant, depending on the sampling location. It has been shown that in the conditions of increased (compared with natural) Pb and Zn content in the soil, SC may serve as a bioaccumulator of these metals. It was determined that SC can be used as a phytostabilizer of Pb and Zn in soils heavily contaminated with these elements. The content of Zn in the aboveground parts of SC indicates that this plant can also be used for phytoextraction of soils contaminated with this metal.
Systematic review of pleural-amniotic shunt insertion vs. conservative management in isolated bilateral fetal hydrothorax without hydrops
Authors: Carson Elaine , Devaseelan Priscilla , Ong Stephen 
Published: November 2019

Abstract
Objective
In the management of bilateral fetal hydrothorax where the fetus is non-hydropic and apparently otherwise normal, we wished to determine if pleural-amniotic shunt insertion was better than conservative management in terms of mortality.

Methods
A systematic review was conducted between 1992 and 2017. Data extracted was inspected for heterogeneity. Where there was comparative data available, the odds ratio (OR) and confidence interval (CI) were calculated.

Results
Seven studies were included in this systematic review. There was a paucity of comparative data where only 2 studies (28 cases) allowed for direct comparison. Within the limitations of the study, there was no difference between shunt insertion vs. conservative management in terms of stillbirth or miscarriage (OR = 1.00, 95% CI 0.12–8.34, heterogeneity I2 = 0%, p = 1.00).

Conclusion
There is insufficient data available to determine whether the outcome is improved by pleural-amniotic shunt insertion compared with conservative management in cases of bilateral fetal hydrothorax where the fetus is non-hydropic and otherwise normal.
Catalogue of the Star graph eigenvalue multiplicities
Authors: Khomyakova Ekaterina , Konstantinova Elena V. 
Published: November 2019

AbstractThe Star graph $$S_n$$

S
n

, $$n\geqslant 2$$

n
⩾
2

, is the Cayley graph over the symmetric group $$\mathrm {Sym}_n$$

Sym
n

generated by transpositions $$(1~i),\,2\leqslant i \leqslant n$$

(
1

i
)
,

2
⩽
i
⩽
n

. This set of transpositions plays an important role in the representation theory of the symmetric group. The spectrum of $$S_n$$

S
n

contains all integers from $$-(n-1)$$

-
(
n
-
1
)

to $$n-1$$

n
-
1

, and also zero for $$n\geqslant 4$$

n
⩾
4

. In this paper we observe methods for getting explicit formulas of eigenvalue multiplicities in the Star graphs $$S_n$$

S
n

, present such formulas for the eigenvalues $$\pm (n-k)$$

±
(
n
-
k
)

, where $$2\leqslant k \leqslant 12$$

2
⩽
k
⩽
12

, and finally collect computational results of all eigenvalue multiplicities for $$n\leqslant 50$$

n
⩽
50

in the catalogue.
Evaluation of Topological Properties of Parallel Manipulators Based on the Topological Characteristic Indexes
Authors: Shen Huiping , Yang Ting-Li , Li Ju , Zhang Dan , Deng Jiaming , Liu Anxin 
Published: November 2019

SUMMARYThe topological structure of a parallel manipulator (PM) determines its intrinsic topological properties (TPs). The TPs further determine essential kinematic and dynamic properties of the mechanism. TPs can be expressed through topological characteristics indexes (TCI). Therefore, defining a set of TCIs is an important issue to evaluate the TPs of PMs. This article addresses the evaluation of topological properties (ETP) of PMs based on TCI. A general and effective ETP method for PMs is proposed. Firstly, 12 TCIs are proposed, including 8 quantitative TCIs, that is, position and orientation characteristics sets (POC), dimension of the POC set, degrees of freedom (DOF), number of independent displacement equations, types and number of an Assur kinematic chain (AKC), coupling degrees of the AKCs, degrees of redundancy and the number of overs; as well as 4 qualitative TCIs, that is, selection of actuated joints, identification of inactive joints, DOF type and Input–Output motion decoupling. Secondly, the ETP method is illustrated by evaluating some well-known PMs including the Delta, Tricept, Exechon, Z3, H4 and the Gough–Stewart platform manipulators, as well as 28 other typical PMs. Via the ETP analysis of these mechanisms also some valuable design knowledge is derived and guidelines for the design of PMs are established. Finally, a 5-DOF decoupled hybrid spraying robot is developed by applying the design knowledge and the design guidelines derived from the ETP analysis.
A Translation or A Revision? The Mandarin Union Version and its use of the Chinese base texts
Authors: TONG CLEMENT TSZ MING 
Published: November 2019

AbstractWhen the plan to translate the Union Version in Guanhua (Mandarin) was announced at the 1890 Conference in Shanghai, it was decided that all three existing Mandarin versions—the 1856 Nanking Version, the 1872 Peking Version, and Griffith John's translation of 1889 - were to be equally used as the Chinese base texts of the new version. The decision was part of an overarching effort of appeasement and compromises, in order to secure the general agreement of the Protestant communities deeply divided over the issues of bible translations since the early days of Morrison and Marshman. In reality the Nanking Version and Griffith John were scarcely consulted, and the Peking Version would be the primary Chinese base text used by the committee. What is not always apparent to scholars and readers of the Mandarin Union Version is the extent it has been modeled after the Peking Version, not only because of the high regard the committee members had for this early Bible translation in Mandarin Chinese, but also as a direct result of the manner by which the Mandarin Union Version was completed in a committee setting. By examining the historical context surrounding the translation of the Mandarin Union Version, and the textual features of it in comparison to the Peking Version, this article calls for a stronger emphasis on the role and influence of the Chinese base text on this widely-used Chinese Bible translation, as its popularity and scholarly interests persist, 100 years after its completion.
AGU Advances Goes Online
Authors: Trumbore Susan , Barros Ana , Davidson Eric , Ehlmann Bethany , Famiglietti James , Gruber Nicolas , Hudson Mary , Illangasekare Tissa , Kang Sarah , Parsons Tom , Rizzoli Paola , Salters Vincent , Stevens Bjorn , Wuebbles Donald , Zeitler Peter , Zhu Tong 
Published: November 2019

AbstractAGU Advances is a premier open access journal with transparent review and with commentary accompanying the research articles that places their results in a wider context.
The Importance of Systematic Spatial Variability in the Surface Heat Flux of a Large Lake: A Multiannual Analysis for Lake Geneva
Authors: Rahaghi A.I. , Lemmin U. , Cimatoribus A.A. , Barry D.A. 
Published: November 2019

AbstractThe spatiotemporal surface heat flux (SurHF) distribution over Lake Geneva, the largest lake in Western Europe, was estimated for a 7‐year period (2008–2014). Data sources included hourly maps of over‐the‐lake assimilated meteorological data from a validated numerical weather model and lake surface water temperature (LSWT) from satellite imagery. A set of bulk algorithms, previously optimized and calibrated at two locations in Lake Geneva, was used. Results indicate a systematic long‐term average spatial range of >40 Wm‐2 between different parts of the lake and little year‐to‐year variability. This variability is mainly due to topographically induced wind sheltering over parts of the lake, which in turn produces spatial variability in the sensible and latent heat fluxes. These results are supported by a systematic spatial heat content variability obtained from long‐term temperature profile measurements in the lake. During spring, a lower SurHF spatial range was evident. Unlike other seasons, the spring spatial variability of air‐water temperature differences and, to a lesser extent, the global radiation variability resulting from sheltering by the mountainous topography were the main drivers of the SurHF spatial variability. Analysis of the atmospheric thermal boundary layer showed stable conditions from March to early June and unstable conditions for the rest of the year. This regime change can explain the low SurHF spatial variability observed during spring. The results emphasize that spatial variability in meteorological and LSWT patterns, and consequently in the spatiotemporal SurHF data, should be considered when assessing the time evolution of the heat budget of large lakes.
Exploring the utility of robots in exposure studies
Authors: Feld-Cook Elisabeth , Shome Rahul , Zaleski Rosemary T. , Mohan Krishnan , Kourtev Hristiyan , Bekris Kostas E. , Weisel Clifford P. , Shin Jennifer 
Published: November 2019

AbstractObtaining valid, reliable quantitative exposure data can be a significant challenge for industrial hygienists, exposure scientists, and other health science professionals. In this proof-of-concept study, a robotic platform was programmed to perform a simple task as a plausible alternative to human subjects in exposure studies for generating exposure data. The use of robots offers several advantages over the use of humans. Research can be completed more efficiently and there is no need to recruit, screen, or train volunteers. In addition, robots can perform tasks repeatedly without getting tired allowing for collection of an unlimited number of measurements using different chemicals to assess exposure impacts from formulation changes and new product development. The use of robots also eliminates concerns with intentional human exposures while removing health research ethics review requirements which are time consuming. In this study, a humanoid robot was programmed to paint drywall, while volatile organic compounds were measured in air for comparison to model estimates. The measured air concentrations generally agreed with more advanced exposure model estimates. These findings suggest that robots have potential as a methodology for generating exposure measurements relevant to human activities, but without using human subjects.
Concurrent activation of growth factor and nutrient arms of mTORC1 induces oxidative liver injury
Authors: Cho Chun-Seok , Kowalsky Allison H. , Namkoong Sim , Park Sung-Rye , Wu Shuangcheng , Kim Boyoung , James Amanda , Gu Bondong , Semple Ian A. , Tohamy Mohamed A. , Solanki Sumeet , Cho Uhn-Soo , Greenson Joel K. , Shah Yatrik M. , Kim Myungjin , Lee Jun Hee 
Published: November 2019

AbstractmTORC1 is a protein kinase important for metabolism and is regulated by growth factor and nutrient signaling pathways, mediated by the Rheb and Rag GTPases, respectively. Here we provide the first animal model in which both pathways were upregulated through concurrent mutations in their GTPase-activating proteins, Tsc1 and Depdc5. Unlike former models that induced limited mTORC1 upregulation, hepatic deletion of both Tsc1 and Depdc5 (DKO) produced strong, synergistic activation of the mTORC1 pathway and provoked pronounced and widespread hepatocyte damage, leading to externally visible liver failure phenotypes, such as jaundice and systemic growth defects. The transcriptome profile of DKO was different from single knockout mutants but similar to those of diseased human livers with severe hepatitis and mouse livers challenged with oxidative stress-inducing chemicals. In addition, DKO liver cells exhibited prominent molecular pathologies associated with excessive endoplasmic reticulum (ER) stress, oxidative stress, DNA damage and inflammation. Although DKO liver pathologies were ameliorated by mTORC1 inhibition, ER stress suppression unexpectedly aggravated them, suggesting that ER stress signaling is not the major conduit of how hyperactive mTORC1 produces liver damage. Interestingly, superoxide scavengers N-acetylcysteine (NAC) and Tempol, chemicals that reduce oxidative stress, were able to recover liver phenotypes, indicating that mTORC1 hyperactivation induced liver damage mainly through oxidative stress pathways. Our study provides a new model of unregulated mTORC1 activation through concomitant upregulation of growth factor and nutrient signaling axes and shows that mTORC1 hyperactivation alone can provoke oxidative tissue injury.
Characteristics of Patent Ductus Arteriosus in Congenital Rubella Syndrome
Authors: Toizumi Michiko , Do Cam Giang T. , Motomura Hideki , Do Tin N. , Fukunaga Hirofumi , Iijima Makiko , Le Nhan NT. , Nguyen Hung Thanh , Moriuchi Hiroyuki , Yoshida Lay-Myint 
Published: November 2019

AbstractThis study investigated the characteristics of congenital rubella syndrome (CRS)-associated cardiac complications, particularly patent ductus arteriosus (PDA). We reviewed the medical records of patients with CRS who were admitted to the Children’s Hospital 1 in Vietnam between December 2010 and December 2012, and patients with CRS who underwent PDA transcatheter occlusion therapy at the cardiology department between December 2009 and December 2015. We compared the characteristics of PDA treated with transcatheter closure between children with CRS (CRS-PDA) and those without CRS (non-CRS-PDA) who underwent PDA transcatheter closure between July 2014 and December 2015. One-hundred-and-eight children with CRS were enrolled. Cardiac defects (99%), cataracts (72%), and hearing impairment (7%) were detected. Fifty CRS-PDA and 290 non-CRS-PDA patients were examined. CRS-PDA patients had smaller median birthweight (p < 0.001), more frequent pulmonary (p < 0.001) and aortic stenosis (p < 0.001), higher main pulmonary artery pressure, and higher aortic pressure in systole/diastole (p < 0.001 for each) than did non-CRS-PDA patients. The proportion of tubular-type PDA was higher in CRS-PDA patients (16%) than in non-CRS-PDA patients (3%) (p = 0.020). Tubular-type PDA was frequently seen in patients with CRS and accompanied by pulmonary/systemic hypertension and pulmonary/aortic stenosis; in these patients, more cautious device selection is needed for transcatheter PDA closure.
Plasticity of histone modifications around Cidea and Cidec genes with secondary bile in the amelioration of developmentally-programmed hepatic steatosis
Authors: Urmi Jeenat Ferdous , Itoh Hiroaki , Muramatsu-Kato Keiko , Kohmura-Kobayashi Yukiko , Hariya Natsuyo , Jain Divyanu , Tamura Naoaki , Uchida Toshiyuki , Suzuki Kazunao , Ogawa Yoshihiro , Shiraki Nobuaki , Mochizuki Kazuki , Kubota Takeo , Kanayama Naohiro 
Published: November 2019

AbstractWe recently reported that a treatment with tauroursodeoxycholic acid (TUDCA), a secondary bile acid, improved developmentally-deteriorated hepatic steatosis in an undernourishment (UN, 40% caloric restriction)in uteromouse model after a postnatal high-fat diet (HFD). We performed a microarray analysis and focused on two genes (Cidea and Cidec) because they are enhancers of lipid droplet (LD) sizes in hepatocytes and showed the greatest up-regulation in expression by UN that were completely recovered by TUDCA, concomitant with parallel changes in LD sizes. TUDCA remodeled developmentally-induced histone modifications (dimethylation of H3K4, H3K27, or H3K36), but not DNA methylation, around the Cidea and Cidec genes in UN pups only. Changes in these histone modifications may contribute to the markedly down-regulated expression of Cidea and Cidec genes in UN pups, which was observed in the alleviation of hepatic fat deposition, even under HFD. These results provide an insight into the future of precision medicine for developmentally-programmed hepatic steatosis by targeting histone modifications.
Changes in Sexual Function Following Uphold Transvaginal mesh Surgery for the Treatment of Urogenital Prolapse
Authors: Hsiao Tsun-Wen , Ker Chin-Ru , Lin Kun-Ling , Juan Yung-Shun , Wu Ming-Ping , Liu Yi-yin , Long Cheng-Yu 
Published: November 2019

AbstractUphold transvaginal mesh implantation is an option for treating pelvic organ prolapse (POP). This prospective cohort study aims to evaluate the effect of Uphold transvaginal mesh implantation on female sexual function. 205 women with symptomatic POP were recruited and evaluated pre-operatively and re- evaluated six months post-operatively in terms of anatomical restoration, quality of life influenced by urinary incontinence and female sexual function. 30 women eventually completed the assessments and been statistically evaluated. The main outcome focused on sexual function. In our study, we found that Uphold transvaginal mesh surgery could achieve effective anatomical restoration of POP and better sexual function regardless of concomitant sling surgery.
Impact of weather seasonality and sexual transmission on the spread of Zika fever
Authors: Dénes Attila , Ibrahim Mahmoud A. , Oluoch Lillian , Tekeli Miklós , Tekeli Tamás 
Published: November 2019

AbstractWe establish a compartmental model to study the transmission of Zika virus disease including spread through sexual contacts and the role of asymptomatic carriers. To incorporate the impact of the seasonality of weather on the spread of Zika, we apply a nonautonomous model with time-dependent mosquito birth rate and biting rate, which allows us to explain the differing outcome of the epidemic in different countries of South America: using Latin Hypercube Sampling for fitting, we were able to reproduce the different outcomes of the disease in various countries. Sensitivity analysis shows that, although the most important factors in Zika transmission are the birth rate of mosquitoes and the transmission rate from mosquitoes to humans, spread through sexual contacts also highly contributes to the transmission of Zika virus: our study suggests that the practice of safe sex among those who have possibly contracted the disease, can significantly reduce the number of Zika cases.
Radiocarbon Production Events and their Potential Relationship with the Schwabe Cycle
Authors: Scifo A. , Kuitems M. , Neocleous A. , Pope B. J. S. , Miles D. , Jansma E. , Doeve P. , Smith A. M. , Miyake F. , Dee M. W. 
Published: November 2019

AbstractExtreme cosmic radiation events occurred in the years 774/5 and 993/4 CE, as revealed by anomalies in the concentration of radiocarbon in known-age tree-rings. Most hypotheses point towards intense solar storms as the cause for these events, although little direct experimental support for this claim has thus far come to light. In this study, we perform very high-precision accelerator mass spectrometry (AMS) measurements on dendrochronological tree-rings spanning the years of the events of interest, as well as the Carrington Event of 1859 CE, which is recognized as an extreme solar storm even though it did not generate an anomalous radiocarbon signature. Our data, comprising 169 new and previously published measurements, appear to delineate the modulation of radiocarbon production due to the Schwabe (11-year) solar cycle. Moreover, they suggest that all three events occurred around the maximum of the solar cycle, adding experimental support for a common solar origin.