bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antiproliferative Effects of Ocimum basilicum Methanolic Extract and Fractions, Oleanolic Acid and 3-epi-Ursolic Acid
Authors: Qamar Kehkashan Arshad , Farooq Ahsana Dar , Siddiqui Bina S. , Kabir Nurul , Begum Sabira 
Published: November 2019

Aims:
The aim of the current study was to identify active compound(s) responsible
for the antiproliferative effects of O. basilicum and explore their underlying mechanism/s.
Background: Plants have been the source of medicines for the treatment of various diseases
since ancient times. Ocimum basilicum (Sweet Basil, Bobai Tulsi) has been used in the folk
medicine for the treatment of human liver, spleen and stomach cancers.

Background:
Plants have been the source of medicines for the treatment of various diseases
since ancient times. Ocimum basilicum (Sweet Basil, Bobai Tulsi) has been used in the folk
medicine for the treatment of human liver, spleen and stomach cancers.

Objective:
To emphasize the importance of O. basilicum as a potential novel non-toxic alternative
to the conventional anticancer therapy.

Method:
O. basilicum (aerial parts) methanolic extract and fractions were screened against
HT-144, MCF-7, NCI-H460 and SF-268 human cancer cell lines using sulforhodamine B
assay. The more active Petroleum Ether Insoluble (PEI) fraction was fractionated into six
sub-fractions (OB-1 to OB-6). Four pure compounds (3-O-methyl ursolic acid, oleanolic acid,
3-epi-ursolic acid and ursolic acid) were isolated from the more potent sub-fraction OB-
6. Triple channel immunofluorescence microscopy was employed to observe the effects of
methanolic extract, PEI fraction, sub-fractions OB-5 and OB-6, 3-epi-ursolic acid and
oleanolic acid on the cytoskeleton and nuclei of MCF-7 cells.

Result:
The methanolic extract and the PEI fraction exhibited selectively greater growth inhibition
against MCF-7 cell line (TGI: 56 and 36.2 µg/ml, respectively). By using triple
channel immunofluorescence microscopy, it was observed that the methanolic extract, PEI
fraction, sub-fraction OB-5 and 3-epi-ursolic acid induced irregular mitotic spindle formation
and slowing of mitotic progression in MCF-7 cells while sub-fraction OB-6 induced
mitotic arrest in the prophase stage. F-actin aggregation was also visible in PEI fraction, subfraction
OB-5 and 3-epi-ursolic acid treated MCF-7 cells.

Conclusion:
These results emphasize the importance of O. basilicum as a potential novel
non-toxic alternative to the conventional anticancer therapy and suggest that it inhibits the
growth of MCF-7 cancer cells via multiple mechanisms such as interaction with the microtubules
and mitotic spindle apparatus, and F-actin aggregation.
Microencapsulation of Crude Folic Acid Extract from Chayote (Sechium edule Jacq. Swartz) with Ionic Gelation Method
Authors: Purba Johana Novita Paulina , Rusmarilin Herla , Lubis Zulkifli 
Published: November 2019

Chayote is a plant which grow and develop throughout the year, contains of 93 mcg/100g folic acid. The aim of this research was to determine the ratio of sodium alginate with pectin and CaCl2 concentration coating to produce microcapsules of crude folic acid extract. Four phases of study was done, namely the manufacture of folic acid extract, manufacture of microcapsules with ionic gelation, analysis of folic acid content in the microcapsules, and the analysis of folic acid after storage of one week. Folic acid extract was made by maceration using alcohol 70% at pH 6, preparation of the microcapsules was using sodium alginate with pectin and folic acid was analysed using HPLC. Folic acid extract showed antioxidant activity of 98,1% with folic acid of 0,16 mg/kg. Microencapsulation of folic acid extract results showed the highest antioxidant activity was formed in alginate ratio of 70% to 30% pectin and CaCl2 concentration of 0.1 M i.e. 62.77 mg/kg. Folic acid is an antioxidant, highest antioxidant value folic acid was analyzed, treatment was in alginate ratio of 70% to 30% pectin and CaCl2 concenration at 0.1 M i.e. 3.06 mg/kg, after one week at room temperature is became 2.39 mg/kg.
Análise quantitativa das sorologias das Hepatites B e C em 2017, em uma capital do Nordeste
Authors: Costa Emannuelle Pessoa Costa Pessoa , Coêlho Hitalo Roberto de Araújo , Fernandes Alice Januário Guedes , Ferraz Jéssica Ohana de Alencar , Silva Moura Laísa Sheffany da Cruz , Silva Lara Kamylla Queiroz , Da Silveira Luana Nascimento , Sousa Mariana de Andrade , De Souza Suyene Maria Lima , Da Silva Fabiano Vieira , Da Silva Machado Herion Alves , Marques Rosemarie Brandim , Martins Liline Maria Soares 
Published: November 2019

As Hepatites Virais dos tipos B e C são uma preocupação constante de saúde pública, devido às suas manifestações agudas e possibilidade de cronificação. Muito se fala sobre as melhores formas de se dar seguimento a um paciente diagnosticado com Hepatite Viral, porém pouco se aborda sobre a eficácia e as rotinas de diagnósticos que são realizadas, as quais refletem na observação de casos de subnotificação e cronificação de quadros agudos que, caso tivessem adequado diagnóstico e tratamento, poderiam não se direcionar para a cronificação. Foram analisados 4.294 exames sorológicos realizados em laboratório de referência em Teresina-Pi. Dos exames analisados, 3.333 eram de avaliação imunológica (bancada), enquadrando-se como as pesquisas de rotina no caso de pacientes com quadros clínicos e epidemiológicos compatíveis. Dos 4.294, 3.248 foram dados como não reagentes, figurando uma alta taxa de não diagnóstico. Os resultados do presente estudo nos permitem concluir que há uma deficiência significativa na atualização de dados nos meios oficiais de acesso aos mesmos, evidenciando uma demonstração destoante da realidade epidemiológica da cidade de Teresina (PI) em relação aos casos de Hepatite B e Hepatite C.
PRÓTESE DENTÁRIA METAL FREE
Authors: Spezzia Sérgio 
Published: November 2019

Resumo Os materiais protéticos detém um papel de relevância, a escolha de um determinado material para uso deve levar em conta vários fatores. Muitas vezes, têm-se um material resistente, mas com poucas características favoráveis quanto a opalescência e translucidez. Deve-se considerar materiais restauradores com propriedades que possibilitem restituir a função e a estética do sorriso. Restaurações livres de metal também chamadas de metal free constituem um desses materiais, que são escolhidos para uso, principalmente, devido características estéticas favoráveis. O sistema metal free permite a obtenção de características estéticas similares as da dentição, no que tange a textura, cor, translucidez e opalescência. O objetivo deste artigo foi verificar como pode-se empregar as próteses dentárias metal free nos procedimentos odontológicos. A procura pelas restaurações cerâmicas livres de metal pelos pacientes tem aumentado nos consultórios odontológicos, uma vez que as mesmas possibilitam a obtenção de uma estética dental satisfatória. Pode-se indicar o emprego das próteses metal free em indivíduos adultos, que detém higienização bucal satisfatoriamente realizada. Pode-se utilizá-las no planejamento e instalação das restaurações tipo overlay, onlay, inlay, para facetas estéticas, entre outros. O planejamento odontológico deve ser executado corretamente e para que obtenha-se desfecho estético favorável, os passos ou procedimentos clínicos para instalação das próteses livres de metal devem ser realizados sequencialmente. Palavras-chave: Sorriso. Estética. Cerâmica. Planejamento. Keywords: Smiling. Esthetics. Ceramics. Planning.
A EXPERIÊNCIA DO PROJETO ABEPSS ITINERANTE: A ATUALIDADE DO PROJETO DE FORMAÇÃO PROFISSIONAL FRENTE À CONTRARREFORMA DA EDUCAÇÃO.
Authors: Abreu Maria Helena Elpidio 
Published: November 2019

O artigo se apresenta como parte da sistematização do Projeto intitulado ABEPSS Itinerante, implementado pela Associação Brasileira de Ensino e Pesquisa em Serviço Social (ABEPSS). Parte da experiência como docente e da análise de elementos avaliativos organizados nos relatórios regionais da Entidade. Trata-se de uma expressão ou apreensão limitada da magnitude do que representou a elaboração, a materialização e os desdobramentos do projeto nas suas dimensões política e pedagógica. Buscou-se articular os pressupostos teóricos que norteiam a análise da realidade e o projeto de formação profissional do Serviço Social no contexto da contrarreforma do ensino superior com os objetivos, possibilidades e desafios levantados com a materialização do Abepss Itinerante. Interessa-nos realçar a experiência como estratégia na defesa Formação Profissional consubstanciada nas Diretrizes Curriculares. Palavras-chave: Serviço Social. Formação Profissional. Projeto ABEPSS Itinerante. Contrarreforma do ensino.
«ЖИВОЕ СЛОВО», Isegoria and the politics of deliberation in revolutionary Russia
Authors: Brandist Craig 
Published: November 2019

This article aims to refl ect on the notion of ‘living word’ from an historical trajectory, recognizing that although this subject has been very current among many intellectuals in the ‘east’ and the ‘west ’it is still object of multiple questions which refer to different readings about this notion.
Tradução e as interfaces na pesquisa
Authors: Zipser Meta Elisabeth , De Abreu Juliana 
Published: November 2019

A grande gama de objetos de pesquisa trabalhados no Programa de Pós-Graduação em Estudos da Tradução (PGET) da Universidade Federal de Santa Catarina (UFSC) assegura a interdisciplinaridade do campo dos Estudos da Tradução com as diferentes áreas do conhecimento. Considerando as diversas interfaces tradutórias, apontamos para alguns dos estudos desenvolvidos no Grupo de Pesquisa Tradução e Cultura (TRAC-CNPq-UFSC), como tradução e ensino, tradução e jornalismo, tradução de artigos científicos, tradução e gastronomia, tradução e publicidade e tradução de quadrinhos. Com base na Análise Textual em Tradução (NORD, 2016) e nos preceitos Funcionalistas de Tradução (REISS, 1983, VERMEER, 1986; NORD, 1991; [1988] 2009; 2016), mostramos a tradução alcançando seu objetivo, quando tratada como ato comunicativo, qual seja, viabilizando a compreensão em um novo contexto de cultura, contemplando o leitor em prospecção, sem perder as características de origem. Traduzir em interfaces significa respeitar os gêneros textuais, as culturas de partida e de chegada, sem perder de vista os objetivos tradutórios.
Looking beyond ejection fraction: what we have in echocardiography
Authors: Baysan Oben , Akyıldız İlke 
Published: November 2019

Left ventricular ejection fraction (LVEF) is the most frequently used echocardiographic parameter. LVEF based heart failure classification, timely intervention in a patient with valvular disease (e.g. aortic stenosis, mitral regurgitation), deterioration of myocardial function in a patient treated with chemotherapy; all need a simple LVEF value for decision-making process. An echocardiographic examination also contains several parameters with invaluable importance. Measurement and evaluation of these parameters should be made in every patient suspected of having myocardial disease.
Experience of transcatheter implantation of CoreValve aortic valve bioprostheses in Clinic of Advanced Medical Technologies named after Nikolay I. Pirogov
Authors: Vasilev A. S. , Shmatov D. V. , Stolyarov M. S. , Sorokin A. A. , Ivanov D. V. , Novikov M. A. , Zyryanova A. V. , Mikhal’chikova N. A. 
Published: November 2019

Background. Every year the number of operations of transcatheter aortic valve implantation increases, and the number of centers performing this intervention increases too. In this article we present the results of the operation of transcatheter aortic valve implantation at the Clinic of Advanced Medical Technologies named after Nikolay I. Pirogov St. Petersburg State University.Material and Methods. From December 2015 to December 2018, the specialists of the Clinic implanted 46 self-expanding transcatheter aortic valves of 2 generations – CoreValve and CoreValve Evolute R. All patients were patients of high and extremely high surgical risk for severe aortic stenosis. The decision on the implementation of TAVI was taken collectively as part of the “Heart Team”.Results. Most operations were performed under general anesthesia with transfemoral access (89%). In 2 cases (4.3%) the conversion of transcatheter surgery into an open cardiac surgery was required due to the development of intraoperative complications. Hospital mortality was 6.5%, non-fatal complications were 21.7%. Now we have mid-term results of CoreValve valves implantation. The functional class of heart failure is estimated to be no higher than II (by NYHA), the observation period is from 6 months to 2.5 years, and the hemodynamic parameters of the valve are satisfactory. Medterm results from the use of CoreValve Evolute R are expected.Conclusion. The TAVI procedure in patients of high and extremely high surgical risk is an alternative to open operation, showing not-worse (non-inferiority) early and medium-term results. Treatment of patients with intraoperative aortic insufficiency of the 2nd degree requires further improvement. Further research is planned with a view to obtaining long-term TAVI results.
Interrelations between heart rate, hypertension, and the other cardiovascular risk factors in Krasnoyarsk Krai population
Authors: Shabalin V. V. , Grinshtein Yu. I. , Ruf R. R. , Shtrikh A. Yu. 
Published: November 2019

Aim. To evaluate the heart rate in the state of rest and to find its interrelations with gender, age, blood pressure level, estimated glomerular filtration rate, and metabolic syndrome components in the representative sample of Krasnoyarsk Krai population.Material and Methods. Within the framework of ESSE-RF study, the representative sample consisted of 1 411 Krasnoyarsk Krai inhabitants aged 25–64 with no history of beta-blocker intake. With IBM SPSS v. 22, we calculated the descriptive statistics and checked group disparities for statistical significance (significant at p≤0.05).Results. The median heart rate in the sample was 72 (66; 78) beats per minute. We found no significant disparities neither in gender (p = 0.182) nor in age groups (p = 0.084). The heart rate in hypertensive people (73 (68; 80) beats per minute) was significantly higher (p < 0.001) compared to those with normal blood pressure (71 (65; 76) beats per minute). Besides, the heart rate over 80 beats per minute was more prevalent in hypertension and prehypertension compared to normal blood pressure. Renal dysfunction was associated with a slight heart rate decrement, while hyperglycemia (blood glucose over 7 mmol/L), hyperuricemia, and obesity (both general and abdominal) were associated with increased heart rate. Dyslipidemia had no association with heart rate.Conclusion. In Krasnoyarsk Krai population, the heart rate significantly increased in people with hypertension, prehypertension, or at least one component of metabolic syndrome (hyperglycemia, obesity, or hyperuricemia). In patients with prehypertension and hypertension, the heart rate over 80 beats per minute was significantly more prevalent compared to people with normal blood pressure.
Association of the I/D polymorphism of angiotensinconverting enzyme gene with the development of essential hypertension
Authors: Pavlova O. S. , Ogurtsova S. E. , Liventseva M. M. , Lakotko T. H. , Korobko I. Y. , Shyshko V. I. , Mrochek A. G. 
Published: November 2019

Objective. To determine the impact of the I/D polymorphism of the angiotensin-converting enzyme (ACE) gene on the development of essential hypertension, taking into account gender differences.Material and Methods. Clinical data were assessed and a molecular genetic study was performed in 602 people including 401 patients with essential hypertension and 201 individuals of the control group, representing the Belarusian ethnic group. Genotyping was performed using the method of polymerase chain reaction and restriction fragment length polymorphism.Results. The distribution of genotypes of the I/D polymorphism of the ACE gene did not differ between patients with hypertension and normotensive individuals: II, ID, and DD genotypes were detected in 100 (24.9%), 192 (47.9%), and 109 (27.2%) patients and in 52 (25.9%), 108 (53.7%), and 41 (20.4%) people of the comparison group, respectively. Differences were found between the distribution of DD genotype in men with hypertension and in the control group, where the frequencies were 28.4% and 17.3% (p  =  0.04), respectively, in contrast to no differences in women: 25.8% and 23.3% (p  =  0.64), respectively. Carrying the DD genotype in men compared with the ID and DD genotypes (recessive model) of the I/D polymorphism of the ACE gene increased the probability of developing essential hypertension by 1.9 times (OR   =   1.89; 95% CI  =  1.04-3.44). The analysis of the prevalence of risk factors depending on the I/D polymorphism of the ACE gene showed that male patients with the DD genotype more often had burdened heredity in regard to the development of premature cardiovascular diseases (23 patients (37.7%)) compared with the individuals with II and ID genotypes: 13 (21.7%) and 14 (14.9%) patients, respectively (χ2  =  1.16; p  =   0.005), and mainly through the paternal line.Conclusions. Development of essential hypertension is associated with the carriership of the mutant DD genotype of I/D polymorphism of the ACE gene in men.
Protocol for the Photogrammetric Survey of Buildings using Unmanned Aerial Vehicles
Authors: Hernández Castro José Roberto 
Published: November 2019

Photogrammetry encompasses imagery interpretative and measurement method to obtain the shape and location of an object. Since the beginning of the Digital Photogrammetry era (late 80’s), the three-dimensional reconstruction of objects has become one of its fundamental goals [Luhmann et al., 2014]. In the last few years, the professional use of Unmanned Aerial Vehicles (UAVs, also known as drones) focused on this goal has increased and matured relatively fast.The purpose of this work was to know if and how the UAVs have changed Photogrammetry: how they have modified the Photogrammetric Process and what the necessary bases are to establish a Protocol that provides the necessary steps to make high quality Photogrammetric Surveys of build-ings.Thanks to the CentroGeo-INEGI project “Desarrollo y Evaluación de Técnicas Avanzadas de Percepción Remota para Alimentar un Catastro Tridimensional”, a team and the author performed a Photogrammetric Survey (of the Ajusco Unit of the National Pedagogical University [UPN] in Mexico City) to evaluate the Protocol.The author prepared this work as a thesis to obtain the degree of Geomatics Engineer from the National Autonomous University of Mexico (UNAM). For more information, check the TesiUNAM website: shorturl.at/fkBQX
Students’ Difficulties in Comprehending Narrative Text
Authors: Khoirunnisa Aulia , Widodo Estu 
Published: November 2019

Reading skill has been found to be one of difficult skills to achieve for many learners of English as a Foreign Language (EFL). Importantly, based on the preliminary study, narrative texts are deemed to be difficult. This study was conducted to investigate the students’ difficulties in reading text at a private primary school in Batu, involving 29 ninth grade students in the academic year of 2018-2019 as the samples. Employing the purposive sampling method by which the best class was selected, the researcher used10-items of a closed-ended questionnaire to collect the data. In the analysis, some aspects of the narrative text such as words, structure, language feature, character, setting, plot, moral value, and point of view were highlighted. Consistently, narrative texts were found to be the most difficult text faced by students at school. According to the English teacher, students got the difficulties because of lack of vocabulary, the use of simple past tense, and the instruction to make sense of the moral values. Further, difficulties pertain to the effort to comprehend the structure, point of view, and the words.
MUHAFAZAKÂR DÜŞÜNCEDE KADININ TOPLUMSAL KONUMU
Authors: DEMİRKANOĞLU Yahya 
Published: November 2019

Her düşünce yapısında olduğu gibi, muhafazakâr düşünce
de toplumsal öğelerin birçoğuna farklı boyutlarda az ya da çok tesirde
bulunmaktadır. Bu düşünce yapısı içinde kadını diğer toplumsal öğelerden ayıran
temel fark, muhafazakâr düşünce öğelerinin her birinin kadının toplumsal konumu
üzerinde etkili olması, hatta büyük oranda bu konumu biçimlendirmesidir. Bu
bağlamda muhafazakâr düşüncede kadının toplumsal konumunu ortaya çıkarmayı
amaçlayan bu çalışma, üç ana boyutta tasarlanmıştır. Birinci bölümde, muhafazakârlık
kavramsal ve tarihsel açıdan; ikinci bölümde ise, öğeleri bakımından irdelenmeye
çalışılmıştır. Son bölümde de söz konusu öğeler esas alınarak kadının toplumsal
konumu, tarihsel ve betimsel araştırma yöntemlerinden yararlanılarak analiz
edilmiştir. Çalışmanın sonunda, muhafazakâr düşüncede kadının toplumsal konumunun
muhafazakârlığa ait din, gelenek, mülkiyet, aile ve düzen gibi öğeler etrafında
şekillendiği; kadına atfedilen patriarkal rollerin, kadının kamusal alandaki görünürlüğünü
‘kadın tabiatıyla uyumlu’ sınırlı bir alanla kısıtladığı sonucuna varılmıştır.

Anahtar Kelimeler: Muhafazakârlık, Kadın, Toplumsal
Cinsiyet

Jel Kodu: Z19, Y80.
KAVRAMSAL OLARAK YOKSULLUK VE TÜRKİYE’DE YOKSULLUKLA MÜCADELE POLİTİKALARININ ETKİLERİ
Authors: YAŞAR Sema , TAŞAR Mehmet Okan 
Published: November 2019

ÖZGünümüzde yoksulluk tüm dünyada çok önemli bir sorun haline gelmiştir. Yoksulluk
hem gelişmiş hem de gelişmekte olan ülkeler için bir sorundur. Yoksulluğun
üzerinde fikir birliğine varılan net bir tanımı yoktur. Genel olarak insanların
yaşaması için gerekli olan mal ve hizmetlere sahip olamaması olarak
tanımlanabilir. Dünya nüfusunun yaklaşık yarısı 2
dolarlık yoksulluk sınırının altında yaşamaktadır. Yoksulluk tüm dünyada olduğu gibi Türkiye’de de göz
ardı edilemeyecek bir sorundur. 1980’li yıllar sonrasında
Türkiye’de gelir dağılımı eşitsizliği ve yoksulluk artış göstermiştir. Türkiye’de
yoksulluk oranları hanehalkı kullanılabilir fert gelirine, gelire dayalı kent
ve kır ayrımına, hanehalkı tipine ve eğitim durumuna göre farklılıklar
göstermektedir. Yoksullukla mücadele politikaları doğrudan ve dolaylı yöntemler
olmak üzere ikiye ayrılır. Türkiye’de son yıllara kadar yoksullukla mücadelede
dolaylı yöntemler hakim olmuştur. Fakat dolaylı yöntemlerin yetersiz olduğunun
anlaşılması ile doğrudan yöntemler uygulanmaya başlanmıştır. Bu amaçla bir
takım sivil toplum örgütlerinin faaliyetleri ön plana çıkmaktadır. Sosyal
Yardımlaşma ve Dayanışma Teşvik Fonu, Yeşil Kart uygulaması, kadınlara yönelik
verilen mikrokrediler bu uygulamalardan bazılarıdır.Anahtar
Kelimeler: Yoksulluk, yoksullukla mücadele, yoksulluğun
ölçülmesi, yoksullukla mücadele yöntemleri Jel Kodları:I32, I38, H53
KÜRESEL KENTE ALTERNATİF OLARAK SAKİN ŞEHİR: TÜRKİYE SAKİN ŞEHİRLERİ ÜZERİNDEN DEĞERLENDİRME
Authors: Yalçın Enes 
Published: November 2019

ÖZKüreselleşme, iletişim teknolojilerinin hızlı gelişimi ve yaygınlaşmasıyla beraber, dünyayı adeta küresel köy haline getiren bir olgudur. Tektipleştirici ve metalaştırıcı bir yanı olan, yerele ait olanın niteliğini değiştirme özelliği gösteren küreselleşme, bilhassa kentleri kendine sahne edinmektedir. Böylelikle olguya karşı sunulan alternatif modeller de kentsel eksende şekillenmektedir. Bu alternatif kentsel akımlardan biri olan, Yavaş Felsefesi’nin kapsamlı bir takipçisi niteliğindeki Sakin Şehir Hareketi’nin uygulayıcıları da, küreselleşmenin neden olduğu tahrip edici tutumun karşısına yerel değerleri çıkarma, doğal yaşam ile barışık biçimde hayat sürme iddiasındadırlar. Çalışmada öncelikle, küreselleşme olgusunun kuramsal düzeyde incelenmesi ve küresel kente alternatif modellerden söz edilmesi yoluna gidilecektir. Ardından, Sakin Şehirler’e ilişkin kavramsal değerlendirme gerçekleştirilip son olarak, çalışmanın inceleme alanının sınırlandırılabilmesi arzusuyla, Türkiye’deki ilk beş sakin şehir üzerinden, sakin şehir faaliyetlerinin, tanıtımlarının, ne denli küresel kente alternatif oluşturabildiği irdelenecektir. Anahtar Kelimeler: Sakin Şehir, Küresellik, Yerellik, Kent Pazarlama.Jel Kodları: R10