bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structure, Morphology, and Electrochemical Properties of Carbon-Coated Lithium-Manganese Orthosilicate with Sucrose as a Carbon Source
Authors: Boczar Maciej , Krajewski Michal , Hamankiewicz Bartosz , Ratynski Maciej , Buchberger Dominika , Czerwinski Andrzej 
Published: February 2020

AbstractLithium-manganese orthosilicate powders were synthesized via a modified solvothermal method. Three different weight ratios of sucrose used as a carbon source were investigated for finding an effective carbon coating process. Synthesized materials were analyzed by structural and morphological (X-ray powder diffraction, scanning electron microscopy, N2 adsorption/desorption, thermogravimetry analysis) and electrochemical (chronopotentiometry, cyclic voltammetry) methods. By increasing the sucrose content, the electrochemical performance improvement of lithium-manganese orthosilicate powder was observed, such as an increase in its specific capacity (132%) and cyclability (5%) compared with uncoated sample. The enhancement in Li2MnSiO4 performance is related to an increase in its electrical conductivity and enlargement in the electrochemically active surface area due to carbon coating process.
Simulation study of relative permeability and the dynamic capillarity of waterflooding in tight oil reservoirs
Authors: Mohammad Rashid S. , Tareen Mohammad Yaqoob Khan , Mengel Abdullah , Shah Syed Ali Raza , Iqbal Javid 
Published: February 2020

AbstractRelative permeability (kr) and the capillary pressure (Pc) are the central key elements defining the multiphase fluids flow behavior in the porous media. However, the dynamic capillarity should consider the dynamic relative permeability and the dynamic capillary pressure while performing waterflooding process in extremely low permeable formations. In order to improve the oil production, the advanced horizontal well drilling along with multiple hydraulic fracturing is generally instigated to penetrate the unconventional resources. The aim of this study is to consider the dynamic capillarity in a commercial reservoir simulation, while utilizing the data gained from the dynamic and steady experiments of the relative permeability and the capillary pressure impacts during waterflooding process in the core plugs of unconventional tight oil reservoirs. The commercial reservoir simulation conducted sensitivity analyses using Computer Modeling Group simulator. The outcomes show that the well production of the reservoir is overestimated while implementing steady data for forecasting due to which the oil saturation decreases more equally and further rapidly. Additionally, the forecast of the well production estimated to breakthrough sooner. However, neglecting the dynamic capillarity causes a huge breakthrough of water influx. Therefore, the core objective of this study is to probe the consequences of taking into consideration the dynamic capillarity in ultra-low permeable formations while giving an alternative perspective to forecast the production of the hydraulically fractured unconventional tight oil reservoirs.
Holocene variability in sea ice and primary productivity in the northeastern Baffin Bay
Authors: Saini Jeetendra , Stein Ruediger , Fahl Kirsten , Weiser Jens , Hebbeln Dierk , Hillaire-Marcel Claude , de Vernal Anne 
Published: February 2020

AbstractArctic sea ice is a critical component of the climate system, known to influence ocean circulation, earth’s albedo, and ocean–atmosphere heat and gas exchange. Current developments in the use of IP25(a sea ice proxy with 25 carbon atoms only synthesized by Arctic sea ice diatoms) have proven it to be a suitable proxy for paleo-sea ice reconstructions over hundreds of thousands to even millions of years. In the NE Baffin Bay, off NW Greenland, Melville Bugt is a climate-sensitive region characterized by strong seasonal sea ice variability and strong melt-water discharge from the Greenland Ice Sheet (GIS). Here, we present a centennial-scale resolution Holocene sea ice record, based on IP25and open-water phytoplankton biomarkers (brassicasterol, dinosterol and HBI III) using core GeoB19927-3 (73° 35.26′ N, 58° 05.66′ W). Seasonal to ice-edge conditions near the core site are documented for most of the Holocene period with some significant variability. In the lower-most part, a cold interval characterized by extensive sea ice cover and very low local productivity is succeeded by an interval (~ 9.4–8.5 ka BP) with reduced sea ice cover, enhanced GIS spring melting, and strong influence of the West Greenland Current (WGC). From ~ 8.5 until ~ 7.8 ka BP, a cooling event is recorded by ice algae and phytoplankton biomarkers. They indicate an extended sea ice cover, possibly related to the opening of Nares Strait, which may have led to an increased influx of Polar Water into NE-Baffin Bay. The interval between ~ 7.8 and ~ 3.0 ka BP is characterized by generally reduced sea ice cover with millennial-scale variability of the (late winter/early spring) ice-edge limit, increased open-water conditions (polynya type), and a dominant WGC carrying warm waters at least as far as the Melville Bugt area. During the last ~ 3.0 ka BP, our biomarker records do not reflect the late Holocene ‘Neoglacial cooling’ observed elsewhere in the Northern Hemisphere, possibly due to the persistent influence of the WGC and interactions with the adjacent fjords. Peaks in HBI III at about ~ 2.1 and ~ 1.3 ka BP, interpreted as persistent ice-edge situations, might correlate with the Roman Warm Period (RWP) and Medieval Climate Anomaly (MCA), respectively, in-phase with the North Atlantic Oscillation (NAO) mode. When integrated with marine and terrestrial records from other circum-Baffin Bay areas (Disko Bay, the Canadian Arctic, the Labrador Sea), the Melville Bugt biomarker records point to close ties with high Arctic and Northern Hemispheric climate conditions, driven by solar and oceanic circulation forcings.
Measurements and calculations of the equilibrium adsorption amounts of CO2–N2, CO–N2, and CO2–CO mixed gases on 13X zeolite
Authors: Shigaki Nobuyuki , Mogi Yasuhiro , Haraoka Takashi , Furuya Eiji 
Published: February 2020

AbstractPressure swing adsorption (PSA) is one practical process for CO2 separation from the exhaust gases in various industries, such as blast furnace gas in steel works. For optimum design of the PSA process, precise estimation of the adsorption equilibrium of mixed gases is desired. The ideal adsorbed solution (IAS) model is a reliable model for this estimation. However, the IAS model requires convergent calculations, which significantly increase the calculation load, especially in dynamic PSA simulations. An analytical formula such as the extended Langmuir (EX-LM) equation is more useful for calculation of the equilibrium adsorption amounts of mixed gases. A drawback of this equation, however, is the uncertainty of the thermodynamic consistency and consequently the accuracy of the calculation results. In order to clarify the necessary conditions for application of the EX-LM equation as an approximation of the IAS model with Langmuir equation (IAS-LM model), both the analytical features and the estimation accuracy of these different methods were evaluated. To evaluate the accuracy of the equations, the equilibrium adsorption amount of mixed gases consisting of CO2, N2, and CO, which are the major gas components of blast furnace gas in steel works, on 13X zeolite were measured experimentally. The results confirmed that the accuracy of the EX-LM equation varies depending on the gas pressure and also the affinities of the adsorbates. Under higher gas pressure conditions, more reliable calculation results were obtained by the IAS-LM model.
K-core robustness in ecological and financial networks
Authors: Burleson-Lesser Kate , Morone Flaviano , Tomassone Maria S. , Makse Hernán A. 
Published: February 2020

AbstractIn many real-world networks, the ability to withstand targeted or global attacks; extinctions; or shocks is vital to the survival of the network itself, and of dependent structures such as economies (for financial networks) or even the planet (for ecosystems). Previous attempts to characterise robustness include nestedness of mutualistic networks or exploration of degree distribution. In this work we present a new approach for characterising the stability and robustness of networks with all-positive interactions by studying the distribution of the k-shell of the underlying network. We find that high occupancy of nodes in the inner and outer k-shells and low occupancy in the middle shells of financial and ecological networks (yielding a “U-shape” in a histogram of k-shell occupancy) provide resilience against both local targeted and global attacks. Investigation of this highly-populated core gives insights into the nature of a network (such as sharp transitions in the core composition of the stock market from a mix of industries to domination by one or two in the mid-1990s) and allow predictions of future network stability, e.g., by monitoring populations of “core” species in an ecosystem or noting when stocks in the core-dominant sector begin to move in lock-step, presaging a dramatic move in the market. Moreover, this “U-shape” recalls core-periphery structure, seen in a wide range of networks including opinion and internet networks, suggesting that the “U-shaped” occupancy histogram and its implications for network health may indeed be universal.
Genomic prediction and GWAS of yield, quality and disease-related traits in spring barley and winter wheat
Authors: Tsai Hsin-Yuan , Janss Luc L. , Andersen Jeppe R. , Orabi Jihad , Jensen Jens D. , Jahoor Ahmed , Jensen Just 
Published: February 2020

AbstractGenome-wide association study (GWAS) and genomic prediction (GP) are extensively employed to accelerate genetic gain and identify QTL in plant breeding. In this study, 1,317 spring barley and 1,325 winter wheat breeding lines from a commercial breeding program were genotyped with the Illumina 9 K barley or 15 K wheat SNP-chip, and phenotyped in multiple years and locations. For GWAS, in spring barley, a QTL on chr. 4H associated with powdery mildew and ramularia resistance were found. There were several SNPs on chr. 4H showing genome-wide significance with yield traits. In winter wheat, GWAS identified two SNPs on chr. 6A, and one SNP on chr. 1B, significantly associated with quality trait moisture, as well as one SNP located on chr. 5B associated with starch content in the seeds. The significant SNPs identified by multiple trait GWAS were generally the same as those found in single trait GWAS. GWAS including genotype-location information in the model identified significant SNPs in each tested location, which were not found previously when including all locations in the GWAS. For GP, in spring barley, GP using the Bayesian Power Lasso model had higher accuracy than ridge regression BLUP in powdery mildew and yield traits, whereas the prediction accuracies were similar using Bayesian Power Lasso model and rrBLUP for yield traits in winter wheat.
Nonstationary flood coincidence risk analysis using time-varying copula functions
Authors: Feng Ying , Shi Peng , Qu Simin , Mou Shiyu , Chen Chen , Dong Fengcheng 
Published: February 2020

AbstractThe coincidence of flood flows in a mainstream and its tributaries may lead to catastrophic floods. In this paper, we investigated the flood coincidence risk under nonstationary conditions arising from climate changes. The coincidence probabilities considering flood occurrence dates and flood magnitudes were calculated using nonstationary multivariate models and compared with those from stationary models. In addition, the “most likely” design based on copula theory was used to provide the most likely flood coincidence scenarios. The Huai River and Hong River were selected as case studies. The results show that the highest probabilities of flood coincidence occur in mid-July. The marginal distributions for the flood magnitudes of the two rivers are nonstationary, and time-varying copulas provide a better fit than stationary copulas for the dependence structure of the flood magnitudes. Considering the annual coincidence probabilities for given flood magnitudes and the “most likely” design, the stationary model may underestimate the risk of flood coincidence in wet years or overestimate this risk in dry years. Therefore, it is necessary to use nonstationary models in climate change scenarios.
Inactivation of Listeria and E. coli by Deep-UV LED: effect of substrate conditions on inactivation kinetics
Authors: Cheng Yifan , Chen Hanyu , Sánchez Basurto Luis Alberto , Protasenko Vladimir V. , Bharadwaj Shyam , Islam Moududul , Moraru Carmen I. 
Published: February 2020

AbstractIrradiation with deep-ultraviolet light-emitting diodes (DUV LEDs) is emerging as a low energy, chemical-free approach to mitigate microbial contamination, but the effect of surface conditions on treatment effectiveness is not well understood. Here, inactivation of L. innocua and E. coli ATCC25922, as examples of Gram-positive and Gram-negative bacteria, respectively, by DUV LED of 280 nm wavelength was studied. Surface scenarios commonly encountered in environmental, clinical or food processing environments were used: nutrient rich surfaces, thin liquid films (TLF), and stainless steel surfaces (SS). DUV LED exposure achieved 5-log reduction for both strains within 10 min in most scenarios, except for TLF thicker than 0.6 mm. Inactivation kinetics in TLF and on dry SS followed the Weibull model (0.96 ≤ R2 ≤ 0.99), but the model overestimated inactivation by small-dose DUV on wet SS. Confocal microscopy revealed in situ that bacteria formed a dense outer layer at the liquid-air interface of the liquid droplet, protecting the cells inside the droplet from the bactericidal DUV. This resulted in lower than anticipated inactivation on wet SS at small DUV doses, and deviation from the Weibull model. These findings can be used to design effective DUV LED disinfection strategies for various surface conditions and applications.
Combination of chemotherapy and PD-1 blockade induces T cell responses to tumor non-mutated neoantigens
Authors: Grimaldi Alessio , Cammarata Ilenia , Martire Carmela , Focaccetti Chiara , Piconese Silvia , Buccilli Marta , Mancone Carmine , Buzzacchino Federica , Berrios Julio Rodrigo Giron , D’Alessandris Nicoletta , Tomao Silverio , Giangaspero Felice , Paroli Marino , Caccavale Rosalba , Spinelli Gian Paolo , Girelli Gabriella , Peruzzi Giovanna , Nisticò Paola , Spada Sheila , Panetta Mariangela , Letizia Cecere Fabiana , Visca Paolo , Facciolo Francesco , Longo Flavia , Barnaba Vincenzo 
Published: February 2020

AbstractHere, we developed an unbiased, functional target-discovery platform to identify immunogenic proteins from primary non-small cell lung cancer (NSCLC) cells that had been induced to apoptosis by cisplatin (CDDP) treatment in vitro, as compared with their live counterparts. Among the multitude of proteins identified, some of them were represented as fragmented proteins in apoptotic tumor cells, and acted as non-mutated neoantigens (NM-neoAgs). Indeed, only the fragmented proteins elicited effective multi-specific CD4+and CD8+T cell responses, upon a chemotherapy protocol including CDDP. Importantly, these responses further increased upon anti-PD-1 therapy, and correlated with patients’ survival and decreased PD-1 expression. Cross-presentation assays showed that NM-neoAgs were unveiled in apoptotic tumor cells as the result of caspase-dependent proteolytic activity of cellular proteins. Our study demonstrates that apoptotic tumor cells generate a repertoire of immunogenic NM-neoAgs that could be potentially used for developing effective T cell-based immunotherapy across multiple cancer patients.
The proximity of aluminium atoms influences the reaction pathway of ethanol transformation over zeolite ZSM-5
Authors: Gołąbek Kinga , Tabor Edyta , Pashkova Veronika , Dedecek Jiri , Tarach Karolina , Góra-Marek Kinga 
Published: February 2020

AbstractThe organization of aluminium atoms in zeolites affects their catalytic properties. Here we demonstrate that the aluminium distribution is a key parameter controlling the reaction pathway of acid catalysed reactions over ZSM-5 zeolites. We study ethanol transformation over two ZSM-5 samples with similar Si/Al ratios of ~15, and with aluminium atoms located mainly at the channel intersections but differently distributed in the framework. One of the samples contains mostly isolated aluminium atoms while the other has a large fraction of two aluminium atoms located in one ring. The FT-IR time-resolved operando study, supported by catalytic results, reveals that the reaction pathway in ethanol transformation over ZSM-5 is controlled by the proximity of aluminium atoms in the framework. ZSM-5 containing mostly isolated Al atoms transforms ethanol in the associative pathway, and conversely ZSM-5 containing a dominating fraction of two aluminium atoms in one ring transforms ethanol in the dissociative pathway.
Efficacy and safety of PARP inhibitors as the maintenance therapy in ovarian cancer: a meta-analysis of nine randomized controlled trials
Authors: Shao Fengping , Liu Jun , Duan Yaoyun , Li Li , Liu Liqun , Zhang Cai , He Shanyang 
Published: February 2020

Abstract
Purpose: Poly ADP ribose polymerase (PARP) inhibitors can effectively kill cancer cells by restraining the activity of DNA repair enzymes and utilizing the characteristics of BRCA mutations. This article evaluates the efficacy and safety of PARP inhibitors (PARPis) in the maintenance treatment of ovarian cancer.
Method: We searched for clinical trials in electronic databases. PARPis efficacy were evaluated by the hazard ratios (HR) and its 95% confidence intervals (95% CI) of overall survival (OS) and progression-free survival (PFS) between the PARPis groups and placebo groups, while the PARPis’ safety was assessed by relative risk (RR) values of adverse events (AEs) between the two arms.
Results: The immature OS data manifested that patients with BRCA mutation receiving PARPis therapy versus placebo therapy appeared to have longer OS (HR = 0.78, 95%CI = 0.61–1.01; P = 0.06). Compared with placebo group, PARP group had a significant advantage in PFS in ovarian cancer patients with BRCA wild-type (BRCAwt), BRCA mutation (BRCAm), BRCA status unclassified, BRCA1 mutation subgroup and the BRCA2 mutation subgroup (BRCAwt: HR = 0.53, 95%CI = 0.42–0.68, P &lt; 0.00001; BRCAm: HR = 0.30, 95%CI = 0.26–0.34, P &lt; 0.00001; BRCA status unclassified: HR = 0.52, 95%CI = 0.41–0.66, P &lt; 0.00001; BRCA1m: HR = 0.38, 95%CI = 0.29–0.48, P &lt; 0.00001; BRCA2m: HR = 0.23, 95%CI = 0.10–0.57, P = 0.001). Our analysis revealed the incidence rates for AEs of grade ≥3 (grades 3 to 4) and serious AEs in PARPis group were 55.19% and 26.29%, respectively.
Conclusion: Our meta-analysis demonstrates that PARPis therapy can significantly improve PFS in ovarian cancer patients, but it has no benefit in OS. However, the therapy is associated with a significant increase in the risk of AEs of grade ≥ 3 and serious AEs.
Role of the Nox4/AMPK/mTOR signaling axe in adipose inflammation-induced kidney injury
Authors: Njeim Rachel , Farhat Theresa , Alkhansa Sahar , Youssef Natalie , Dia Batoul , Slika Rasha , Diab Radwan , Azar Sami T. , Eid Assaad A. 
Published: February 2020

AbstractDiabetic kidney disease is one of the most serious complications of diabetes worldwide and is the leading cause of end-stage renal disease. While research has primarily focused on hyperglycemia as a key player in the pathophysiology of diabetic complications, recently, increasing evidence have underlined the role of adipose inflammation in modulating the development and/or progression of diabetic kidney disease. This review focuses on how adipose inflammation contribute to diabetic kidney disease. Furthermore, it discusses in detail the underlying mechanisms of adipose inflammation, including pro-inflammatory cytokines, oxidative stress, and AMPK/mTOR signaling pathway and critically describes their role in diabetic kidney disease. This in-depth understanding of adipose inflammation and its impact on diabetic kidney disease highlights the need for novel interventions in the treatment of diabetic complications.
VLTI-PIONIER imaging of the red supergiant V602 Carinae
Authors: Climent J. B. , Wittkowski M. , Chiavassa A. , Baron F. , Marcaide J. M. , Guirado J. C. , Freytag B. , Höfner S. , Haubois X. , Woillez J. 
Published: February 2020

Context. Red supergiant stars possess surface features and extended molecular atmospheres. Photospheric convection may be a crucial factor of the levitation of the outer atmospheric layers. However, the mechanism responsible is still poorly understood.
Aims. We image the stellar surface of V602 Carinae (V602 Car) to constrain the morphology and contrast of the surface features and of the extended atmospheric layers.
Methods. We observed V602 Car with the Very Large Telescope Interferometer PIONIER instrument (1.53–1.78 μm) between May and July 2016, and April and July 2019 with different telescope configurations. We compared the image reconstructions with 81 temporal snapshots of 3D radiative-hydrodynamics (RHD) CO5BOLD simulations in terms of contrast and morphology, using the Structural Similarity Index.
Results. The interferometric data are compatible with an overall spherical disk of angular diameter 4.4 ± 0.2 mas, and an extended molecular layer. In 2016, the reconstructed image reveals a bright arc-like feature toward the northern rim of the photospheric surface. In 2019, an arc-like feature is seen at a different orientation and a new peak of emission is detected on the opposite side. The contrasts of the reconstructed surface images are 11% ± 2% and 9% ± 2% for 2016 and 2019, respectively. The morphology and contrast of the two images are consistent with 3D RHD simulations, within our achieved spatial resolution and dynamic range. The extended molecular layer contributes 10–13% of the total flux with an angular diameter of 6–8 mas. It is present but not clearly visible in the reconstructed images because it is close to the limits of the achieved dynamic range. The presence of the molecular layer is not reproduced by the 3D RHD simulations.
Conclusions. 3D RHD simulations predict substructures similar to the observed surface features of V602 Car at two different epochs. We interpret the structure on the stellar surface as being related to instationary convection. This structure is further convolved to larger observed patches on the stellar surface with our observational spatial resolution. Even though the simulations reproduce the observed features on the stellar surface, convection alone may not be the only relevant process that is levitating the atmosphere.
Chirurgie Orthognathique des patients séniors : repoussons les limites
Authors: Charrier Jean-Baptiste 
Published: February 2020

Le patient sénior tel qu’il est défini dans les modalités de cette monographie est âgé de 55 à 75 ans.
La chirurgie orthognathique s’est considérablement développée ces dernières années. Les techniques chirurgicales, les techniques d’anesthésie, le matériel d’ostéosynthèse, la prise en charge orthodontique et les capacités de réhabilitation parodontales et implanto-portées se sont fortement améliorées et ont permis un développement de cette chirurgie avec un élargissement remarquable, tant concernant les indications que la tranche d’âge de patients susceptibles de bénéficier de ce type de chirurgie.
Dans cet article nous définissons les modalités, avantages et inconvénients spécifiques, inhérents à la prise en charge d’un patient sénior.
L’accent est mis sur les dimensions physiologique, psychologique et esthétique, dont il faut tout particulièrement tenir compte pour optimiser cette chirurgie.