bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling the electrical power and energy consumption of automated guided vehicles to improve the energy efficiency of production systems
Authors: Meißner Matthias , Massalski Lynn 
Published: August 2020

AbstractDue to the advancing energy system transformation and the increasingly complex and dynamic environment in which factories have to operate, the energy efficiency and flexible design of production systems are becoming more important. Since the use of automated guided vehicles is a promising approach to enhance the flexibility of intralogistics, their electrical power requirements are analyzed. Based on the measurement data obtained, different movement modules of an automated guided vehicle are identified and then modeled using physical laws. These movement modules are the translatory movement, rotary movement, and the lifting and lowering of the load-carrying platform. The measurement data show, for example, that the energy requirement for translational and rotational movement increases in relation to the payload weight. At the same time, however, it is also shown that an increase in speed of the automated guided vehicle leads to a lower energy requirement, although the power requirement grows. Consequently, one result is that an automated guided vehicle works most efficiently when the maximum payload is transported at the highest speed. With regard to the lifting and lowering of loads, the result is an increasing energy requirement depending on the payload weight. The comparison between the collected measurement data and the outcomes of the implemented simulation model shows only minor deviations. Thus, the implemented simulation model of automated guided vehicles can be used with regard to their electrical power consumption, for example, in production planning to comprehensively raise the energy efficiency of production systems.
Best integer equivariant estimation for elliptically contoured distributions
Authors: Teunissen P. J. G. 
Published: August 2020

AbstractThis contribution extends the theory of integer equivariant estimation (Teunissen in J Geodesy 77:402–410, 2003) by developing the principle of best integer equivariant (BIE) estimation for the class of elliptically contoured distributions. The presented theory provides new minimum mean squared error solutions to the problem of GNSS carrier-phase ambiguity resolution for a wide range of distributions. The associated BIE estimators are universally optimal in the sense that they have an accuracy which is never poorer than that of any integer estimator and any linear unbiased estimator. Next to the BIE estimator for the multivariate normal distribution, special attention is given to the BIE estimators for the contaminated normal and the multivariatet-distribution, both of which have heavier tails than the normal. Their computational formulae are presented and discussed in relation to that of the normal distribution.
Clinical translation and implementation of optical imaging agents for precision image-guided cancer surgery
Authors: Achterberg F. B. , Deken M. M. , Meijer R. P. J. , Mieog J. S. D. , Burggraaf J. , van de Velde C. J. H. , Swijnenburg R. J. , Vahrmeijer A. L. 
Published: August 2020

Abstract
Introduction
The field of tumor-specific fluorescence-guided surgery has seen a significant increase in the development of novel tumor-targeted imaging agents. Studying patient benefit using intraoperative fluorescence-guided imaging for cancer surgery is the final step needed for implementation in standard treatment protocols. Translation into phase III clinical trials can be challenging and time consuming. Recent studies have helped to identify certain waypoints in this transition phase between studying imaging agent efficacy (phase I–II) and proving patient benefit (phase III).

Trial initiation
Performing these trials outside centers of expertise, thus involving motivated clinicians, training them, and providing feedback on data quality, increases the translatability of imaging agents and the surgical technique. Furthermore, timely formation of a trial team which oversees the translational process is vital. They are responsible for establishing an imaging framework (camera system, imaging protocol, surgical workflow) and clinical framework (disease stage, procedure type, clinical research question) in which the trial is executed. Providing participating clinicians with well-defined protocols with the aim to answer clinically relevant research questions within the context of care is the pinnacle in gathering reliable trial data.

Outlook
If all these aspects are taken into consideration, tumor-specific fluorescence-guided surgery is expected be of significant value when integrated into the diagnostic work-up, surgical procedure, and follow-up of cancer patients. It is only by involving and collaborating with all stakeholders involved in this process that successful clinical translation can occur.

Aim
Here, we discuss the challenges faced during this important translational phase and present potential solutions to enable final clinical translation and implementation of imaging agents for image-guided cancer surgery.
FGOALS-g3 Model Datasets for CMIP6 Flux-Anomaly-Forced Model Intercomparison Project
Authors: Wang Yaqi , Yu Zipeng , Lin Pengfei , Liu Hailong , Jin Jiangbo , Li Lijuan , Tang Yanli , Dong Li , Chen Kangjun , Li Yiwen , Yang Qian , Ding Mengrong , Meng Yao , Zhao Bowen , Wei Jilin , Ma Jinfeng , Sun Zhikuo 
Published: August 2020

AbstractThe Flux-Anomaly-Forced Model Intercomparison Project (FAFMIP) is an endorsed Model Intercomparison Project in phase 6 of the Coupled Model Intercomparison Project (CMIP6). The goal of FAFMIP is to investigate the spread in the atmosphere-ocean general circulation model projections of ocean climate change forced by increased CO2, including the uncertainties in the simulations of ocean heat uptake, global mean sea level rise due to ocean thermal expansion and dynamic sea level change due to ocean circulation and density changes. The FAFMIP experiments have already been conducted with the Flexible Global Ocean-Atmosphere-Land System Model, gridpoint version 3.0 (FGOALS-g3). The model datasets have been submitted to the Earth System Grid Federation (ESGF) node. Here, the details of the experiments, the output variables and some baseline results are presented. Compared with the preliminary results of other models, the evolutions of global mean variables can be reproduced well by FGOALS-g3. The simulations of spatial patterns are also consistent with those of other models in most regions except the North Atlantic and the Southern Ocean, indicating large uncertainties in the regional sea level projections of these two regions.
Homocysteine-induced decrease in HUVEC cells’ resistance to oxidative stress is mediated by Akt-dependent changes in iron metabolism
Authors: Borkowska Andzelika , Ziolkowski Wieslaw , Kaczor Katarzyna , Herman-Antosiewicz Anna , Knap Narcyz , Wronska Agata , Antosiewicz Jedrzej 
Published: August 2020

Abstract
Purpose
Hyperhomocysteinemia is an independent risk factor for cardiovascular diseases and also promotes neuronal death in various neurodegenerative diseases. There is evidence that iron can mediate homocysteine (Hcy) toxicity. Thus, the aim of this study was to investigate the effect of Hcy on iron metabolism in HUVEC and SH-SY5Y cells.

Methods
HUVEC and SH-SY5Y cells were treated with 3 mM Hcy for a defined time.

Results
We demonstrate that Hcy induced the upregulation of ferritins type L and H in HUVEC cells in a time-dependent manner and had no effect on the ferritins in SH-SY5Y cells. The change in ferritin expression was preceded by a significant decrease in the cellular level of the active form of Akt kinase in HUVEC but not in SH-SY5Y cells. An increase in ferritin L and H protein levels was observed in the Akt1, Akt2, Akt3 siRNA transfected cells, while in the cells transfected with FOXO3a siRNA, a decrease in both ferritins levels was noticed. Moreover, in the HUVEC cells treated with Hcy for 6 days, the active form of kinase Akt returned to the control level and it was accompanied by a drop in ferritin L and H protein levels. Cytotoxicity of hydrogen peroxide significantly increased in HUVEC cells pre-treated with Hcy for 24 h.

Conclusions
These data indicate that Hcy induces an increase in cellular ferritin level, and the process is mediated by alterations in Akt-FOXO3a signaling pathway.
Post-mortem genetic investigation of cardiac disease–associated genes in sudden infant death syndrome (SIDS) cases
Authors: Köffer Jasmin , Scheiper-Welling Stefanie , Verhoff Marcel A. , Bajanowski Thomas , Kauferstein Silke 
Published: August 2020

AbstractThe sudden infant death syndrome (SIDS) is one of the leading causes of postneonatal infant death. It has been shown that there exists a complex relationship between SIDS and inherited cardiac disease. Next-generation sequencing and surveillance of cardiac channelopathy and cardiomyopathy genes represent an important tool for investigating the cause of death in SIDS cases. In the present study, targeted sequencing of 80 genes associated with genetic heart diseases in a cohort of 31 SIDS cases was performed. To determine the spectrum and prevalence of genetic heart disease associated mutations as a potential monogenic basis for SIDS, a stringent variant classification was applied and the percentage of rare (minor allele frequency ≤ 0.2%) and ultra-rare variants (minor allele frequency ≤ 0.005%) in these genes was assessed. With a minor allele frequency of ≤ 0.005%, about 20% of the SIDS cases exhibited a variant of uncertain significance (VUS), but in only 6% of these cases, gene variants proved to be “potentially informative.” The present study shows the importance of careful variant interpretation. Applying stringent criteria misinterpretations are avoided, as the results of genetic analyses may have an important impact of the family members involved.
Differences in morphology and visual function of myelin oligodendrocyte glycoprotein antibody and multiple sclerosis associated optic neuritis
Authors: Vicini Rino , Brügger Dominik , Abegg Mathias , Salmen Anke , Grabe Hilary Michelle 
Published: August 2020

Abstract
Background
Myelin oligodendrocyte glycoprotein immunoglobulin G associated optic neuritis (MOG-ON) is a recently described entity. Recent studies have shown that MOG-ON has a more severe clinical presentation than classic optic neuritis (ON).

Objective
This study aimed to define morphological characteristics of MOG-ON, correlate these with clinical characteristics and compare them with multiple sclerosis associated ON (MS-ON) and healthy controls (CTRL).

Methods
In a retrospective study, we included MOG-ON and MS-ON patients seen between 2011 and 2018 at the University Hospital Bern. Data from clinical examination, perimetry, and optical coherence tomography (OCT) were analyzed.

Results
A total of 66 eyes of 43 patients were included; 22 MS-ON and 33 CTRL eyes were sex- and age-matched to 11 MOG-ON eyes. We found significantly worse visual acuity at nadir, but better recovery and thinner global peripapillary retinal nerve fiber layer thickness in MOG-ON patients compared to MS-ON patients. Both groups exhibited irregular thinning of the macular ganglion cell layer. Furthermore, the visual acuity and visual field parameters correlated to retinal layer thickness only in MOG-ON eyes.

Conclusion
In comparison to MS-ON, MOG-ON is associated with more prominent acute vision loss and more pronounced global thinning of the pRNFL. Both entities result in similar final visual acuity and atrophy of the macular ganglion cell layer.
Structural and functional consequences in the amygdala of leptin-deficient mice
Authors: Schepers Jens , Gebhardt Christine , Bracke Alexander , Eiffler Ina , von Bohlen und Halbach Oliver 
Published: August 2020

AbstractOn the one hand, the emotional state can influence food intake and on the other hand, hunger can have an impact on the emotional state. Leptin, which is encoded by the ob gene, is involved in the energy homeostasis and plays a role in development of obesity. Mice deficient for leptin (ob/ob) are obese and display several behavioral alterations. It has been shown that ob/ob mice display striking changes in neuronal plasticity within the limbic system, e.g., hippocampal formation. We focus on alterations in ob/ob mice that can be related to alter processing in another part of the limbic system, the amygdala. ob/ob mice have a higher food consumption than age-matched controls, which might have an impact on the emotional state of these mice. Since the amygdala is involved in emotional processing, we analyze whether ob/ob mice display alterations in plasticity at the electrophysiological and structural level. No changes were seen in dendritic spine densities in the basolateral and lateral (LA) nucleus of the amygdala. Interestingly and in contrast to the hippocampus (Porter et al. 2013), long-term potentiation in the LA was increased in ob/ob mice. Our results indicate that amygdalar and hippocampal synaptic plasticity are regulated in different ways by leptin deficiency in accordance with the different functions of these limbic structures in stress and anxiety.
Variation in susceptibility of rapeseed cultivars to the peach potato aphid
Authors: Kordan Bożena , Wróblewska-Kurdyk Anna , Bocianowski Jan , Stec Katarzyna , Jankowski Krzysztof , Gabryś Beata 
Published: August 2020

AbstractConsidering the need for reduction in insecticide use, we studied the potential for antibiosis and the potential for antixenosis in seven highly yielding winter Brassica napus L. cultivars against Myzus persicae (Sulz.). We found evidence for antixenosis, i.e., disruption in probing in non-phloem tissues and a failure in reaching sieve elements in cultivar ‘Alister’. We found evidence for antibiosis, i.e., reduced ability of the plant to serve as a host, in cultivar ‘Florida’. On ‘Alister’ and ‘Florida’, net reproduction and reproductive period duration of M. persicae were the lowest of all studied cultivars. ‘Adriana’, ‘Andromeda’, ‘Gladius’, and ‘Kolumb’ are intermediately susceptible to M. persicae infestation with medium values of net reproduction and reproduction period duration, and slight disturbances in aphid probing and feeding. ‘Artoga’ is highly susceptible. On ‘Artoga’, reproduction period was the longest, daily fecundity and net reproduction of M. persicae were highest, and probing and feeding behaviors were unaltered. Glucoallysin, glucobrassicanapin, gluconapin, gluconapoliferin, progoitrin, glucobrassicin, and 4-OH-glucobrassicin occurred in the leaves of all rapeseed cultivars in similar quantities and proportions and did not affect aphid performance and phloem sap ingestion by M. persicae.
Neonatal Multisensory Processing in Preterm and Term Infants Predicts Sensory Reactivity and Internalizing Tendencies in Early Childhood
Authors: Maitre Nathalie L. , Key Alexandra P. , Slaughter James C. , Yoder Paul J. , Neel Mary Lauren , Richard Céline , Wallace Mark T. , Murray Micah M. 
Published: August 2020

AbstractMultisensory processes include the capacity to combine information from the different senses, often improving stimulus representations and behavior. The extent to which multisensory processes are an innate capacity or instead require experience with environmental stimuli remains debated. We addressed this knowledge gap by studying multisensory processes in prematurely born and full-term infants. We recorded 128-channel event-related potentials (ERPs) from a cohort of 55 full-term and 61 preterm neonates (at an equivalent gestational age) in response to auditory, somatosensory, and combined auditory-somatosensory multisensory stimuli. Data were analyzed within an electrical neuroimaging framework, involving unsupervised topographic clustering of the ERP data. Multisensory processing in full-term infants was characterized by a simple linear summation of responses to auditory and somatosensory stimuli alone, which furthermore shared common ERP topographic features. We refer to the ERP topography observed in full-term infants as “typical infantile processing” (TIP). In stark contrast, preterm infants exhibited non-linear responses and topographies less-often characterized by TIP; there were distinct patterns of ERP topographies to multisensory and summed unisensory conditions. We further observed that the better TIP characterized an infant’s ERPs, independently of prematurity, the more typical was the score on theInfant/Toddler Sensory Profile(ITSP) at 12 months of age and the less likely was the child to the show internalizing tendencies at 24 months of age. Collectively, these results highlight striking differences in the brain’s responses to multisensory stimuli in children born prematurely; differences that relate to later sensory and internalizing functions.
Accuracy of breast MRI in patients receiving neoadjuvant endocrine therapy: comprehensive imaging analysis and correlation with clinical and pathological assessments
Authors: Reis Joana , Lindstrøm Jonas Christoffer , Boavida Joao , Gjesdal Kjell-Inge , Park Daehoon , Bahrami Nazli , Seyedzadeh Manouchehr , Melles Woldegabriel A. , Sauer Torill , Geisler Jürgen , Geitung Jonn Terje 
Published: August 2020

Abstract
Purpose
To assess the accuracy of magnetic resonance imaging (MRI) measurements in locally advanced oestrogen receptor-positive and human epidermal growth factor receptor 2-negative breast tumours before, during and after neoadjuvant endocrine treatment (NET) for evaluation of tumour response in comparison with clinical and pathological assessments.

Methods
This prospective study enrolled postmenopausal patients treated neoadjuvant with letrozole and exemestane given sequentially in an intra-patient cross-over regimen. Fifty-four patients were initially recruited, but only 35 fulfilled the inclusion criteria and confirmed to participate with a median age of 77. Tumours were scanned with MRI prior to treatment, during the eighth week of treatment and prior to surgery. Additionally, changes in longest diameter on clinical examination (CE) and tumour size at pathology were determined. Pre- and post-operative measurements of tumour size were compared in order to evaluate tumour response.

Results
The correlation between post-treatment MRI size and pathology was moderate and higher with a correlation coefficient (r) 0.64 compared to the correlation between CE and pathology r = 0.25. Post-treatment MRI and clinical results had a negligible bias towards underestimation of lesion size. Tumour size on MRI and CE had 0.82 cm and 0.52 cm lower mean size than tumour size measured by pathology, respectively.

Conclusions
The higher correlation between measurements of residual disease obtained on MRI and those obtained with pathology validates the accuracy of imaging assessment during NET. MRI was found to be more accurate for estimating complete responses than clinical assessments and warrants further investigation in larger cohorts to validate this finding.
Climatic changes and the fate of mountain herbivores
Authors: Lovari Sandro , Franceschi Sara , Chiatante Gianpasquale , Fattorini Lorenzo , Fattorini Niccolò , Ferretti Francesco 
Published: August 2020

AbstractMountains are strongly seasonal habitats, which require special adaptations in wildlife species living on them. Population dynamics of mountain ungulates are largely determined by the availability of rich food resources to sustain lactation and weaning during summer. Increases of temperature affect plant phenology and nutritional quality. Cold-adapted plants occurring at lower elevations will shift to higher ones, if available. We predicted what could happen to populations of mountain ungulates based on how climate change could alter the distribution pattern and quality of high-elevation vegetation, using the “clover community-Apennine chamoisRupicapra pyrenaica ornata” system. From 1970 to 2014, increasing spring temperatures (2 °C) in our study area led to an earlier (25 days) onset of green-up in Alpine grasslands between 1700 and 2000 m, but not higher up. For 1970–2070, we have projected trends of juvenile winter survival of chamois, by simulating trajectories of spring temperatures and occurrence of clover, through models depicting four different scenarios. All scenarios have suggested a decline of Apennine chamois in its historical core range, during the next 50 years, from about 28% to near-extinction at about 95%. The negative consequences of climate changes presently occurring at lower elevations will shift to higher ones in the future. Their effects will vary with the species-specific ecological and behavioural flexibility of mountain ungulates, as well as with availability of climate refugia. However, global shifts in distributional ranges and local decreases or extinctions should be expected, calling for farsighted measures of adaptive management of mountain-dwelling herbivores.
Reactions to (the absence of) control and workplace arrangements: experimental evidence from the internet and the laboratory
Authors: Schmelz Katrin , Ziegelmeyer Anthony 
Published: August 2020

AbstractThis paper reports an experiment designed to assess the influence of workplace arrangements on the reactions to (the absence of) control. We compare behavior in an Internet and a laboratory principal-agent game where the principal can control the agent by implementing a minimum effort requirement. Then the agent chooses an effort costly to her but beneficial to the principal. Our design captures meaningful differences between working from home and working at the office arrangements. Online subjects enjoy greater anonymity than lab subjects, they interact in a less constrained environment than the laboratory, and there is a larger physically-oriented social distance between them. Control is significantly more effective online than in the laboratory. Positive reactions to the principal’s choice not to control are observed in both treatments, but they are significantly weaker online than in the laboratory. Principals often choose the highest control level, which maximizes their earnings.
Thinking with ‘lexical’ features to reconceptualize the ‘grammar’ of schooling: Shifting the focus from school to society
Authors: Courtney Steven J. , Mann Bryan 
Published: August 2020

AbstractAchieving changes to education practices and structures is a significant issue facing reformers internationally, and researchers have confronted how such changes, and the conditions for these, might be conceptualized. These issues resonate particularly as researchers grapple with imagining a post-COVID-19 landscape where social and educational norms may change. Tyack and Tobin, in their 1994 article ‘The “Grammar” of Schooling: Why has it been so hard to change?’ argued that several features of the American education system are so persistent as to warrant being understood as the ‘grammar’ of schooling. In this article, we reconceptualize this ‘grammar’ by taking seriously Tyack and Tobin’s insistence that ‘grammar’ organises meaning. Starting here, we argue that what they took to be grammatical features are the products and not the producers of meaning. We draw on the cases of the United States and England to argue that four international discourses have performed this meaning-making work: industrialization; welfarism; neoliberalism and neoconservatism. These are the ‘grammars’ of schooling—and of society. Their discursive products, including age grading and sorting into subjects are, we suggest, ‘lexical’ features that express the grammar. We use lexical features to explain the multi-directional interplay between discourse and educational feature: the lexical may endure longer than the grammatical, changes to which may be effected and/or legitimated through appealing to a lexical feature. We conclude by outlining key implications for realizing and conceptualizing educational change, including for a post-COVID-19 landscape.