bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alternative learning system program's implementation landscape of a division in the Philippines
Authors: Abad Grace , Galleto Patrick 
Published: October 2020

The study aimed to determine the Alternative Learning System (ALS) Program's implementation landscape in the Division of Dapitan City, Philippines, through the support mechanism's lens to instruction, teachers' attitude, and best practices. It utilized survey and correlational methods of research using a questionnaire checklist. Results revealed that ALS instruction's high support mechanism was small and positively low but significantly related to the teachers' highly positive attitudes towards work and the teachers' best practices in implementing the program. However, room for more significant improvement is deemed essential to raise the high to very high support since the teachers as implementers of the program possessed high disposition and registered best practices in embracing the program's implementation in the city. Hence, the division's administration should look for the best ways to raise funds and not rely only on the government's budget. The effort may be moderated by the proposed Enhanced Alternative Learning System Development Plan.

Keywords: Support mechanism, attitude, best practices
Upaya Meningkatkan Kemampuan Pemahaman Konsep Matematika Siswa dengan Model Pembelajaran Jigsaw Berbantuan Geogebra di Kelas XI IPS 1 SMA Diponegoro 1 Jakarta
Authors: Ananda Muhamad Irfany , Makmuri  , Lukman El Hakim  
Published: October 2020

ABSTRAK
Penelitian ini bertujuan untuk mengetahui peningkatan kemampuan pemahaman konsep matematika siswa kelas XI melalui model pembelajaran jigsaw berbantuan geogebra di SMA Diponegoro 1 Jakarta dengan subjek penilitian siswa kelas XI, dengan jumlah siswa 25 orang yang terdiri dari 13 siswa laki-laki dan 12 siswa perempuan. Subjek penelitian diambil secara acak purposive. Prosedur pelaksanaan tindakan merupakan suatu siklus yang terdiri dari 4 (empat) tahap yaitu: 1) Perencanaan, 2) Pelaksanaan, 3) Analisis, dan 4) Refleksi. Pengumpulan data dilakukan dengan observasi dan evaluasi tes. Hasil observasi aktivitas menunjukkan bahwa adanya peningkatan pada setiap siklus. Hal ini berdasarkan hasil rata-rata nilai tes akhir tiap siklus, pada siklus I nilai rata-rata 64,44, mengalami peningkatan pada siklus II menjadi 65,9, kemudian meningkat kembali pada siklus III menjadi 75,7. Kemudian pada siklus I hanya 32% siswa yang memperoleh nilai kriteria ketuntasan minimal (KKM), pada siklus II meningkat menjadi 44% dan pada siklus III meningkat menjadi 80%.
Kata kunci: Kemampuan Pemahaman Konsep Matematika, Model Pembelajaran Jigsaw, Geogebra.
Pengaruh Model Pembelajaran Kooperatif Tipe Think Talk Write (TTW) dengan Pendekatan Kontekstual terhadap Kemampuan Koneksi Matematis Siswa SMP Negeri 97 Jakarta
Authors: Rafidah Rana , Purwanto Swida , Dwi Antari Wijayanti  
Published: October 2020

Penelitian ini bertujuan untuk mengetahui apakah terdapat pengaruh model pembelajaran kooperatif tipe Think Talk Write (TTW) dengan pendekatan kontekstual terhadap kemampuan koneksi matematis siswa SMP Negeri 97 Jakarta. Metode penelitian yang digunakan adalah eksperimen semu dengan desain penelitian yaitu Posttest Only Control Group Design. Populasi pada penelitian ini adalah seluruh siswa kelas VIII SMP Negeri 97 Jakarta, sedangkan sampelnya yaitu siswa kelas VIII-E sebagai kelas kontrol yang menerapkan model pembelajara langsung dan siswa kelas VIII-F sebagai kelas eksperimen yang menerapkan model pembelaran kooperatif tipe Think Talk Write (TTW) dengan pendekatan kontekstual. Instrumen yang digunakan pada penelitian ini adalah tes kemampuan koneksi matematis pada materi sistem persamaan linear dua variable berupa uraian sebanyak lima butir soal yang sebelumnya sudah dinyatakan valid. Analisis data menggunakan uji-t untuk dua sampel independen dengan taraf signifikansi pada data yang berdistribusi normal dan homogen. Berdasarkan hasil perhitungan diperoleh dan sehingga maka ditolak yang berarti rata-rata skor tes kemampuan koneksi matematis siswa kelas eksperimen lebih tinggi dari kelas kontrol. Pengujian dilanjutkan dengan Cohen-Test untuk melihat besar pengaruh model pembelajaran kooperatif tipe Think Talk Write (TTW) dengan pendekatan kontekstual terhadap kemampuan koneksi matematis siswa. Berasarkan hasil perhitungan, diperoleh nilai dengan persentasi 88% yang berada pada kategori besar. Hal ini menunjukkan bahwa model pembelajaran Think Talk Write (TTW) dengan pendekatan kontekstual berpengaruh terhadap kemampuan koneksi matematis siswa SMP Negeri 97 Jakarta.
ОСОБЕННОСТИ ИММУННОГО РЕАГИРОВАНИЯ НА ВИРУС SARS-COV-2.
Authors: Гришаева Антонина , Турапова Александра , Понежева Жанна , Алешина Нина , Малеев Виктор 
Published: October 2020

Клинические проявления новой коронавирусной инфекции разнообразны, от бессимптомного течения до развития острого респираторного дистресс-синдрома и мультиорганной дисфункции. В настоящее время доказано, что тяжесть состояния коррелирует с повышением уровня воспалительных цитокинов, таких как IL6, IL2, IL7, IL10,
GCSF, IP10, MCP1, MIP1A и TNFa. Данное явление получило название «цитокинового шторма». В данном обзоре рассмотрены современные представления об особенностях иммунного ответа на SARS-COV2.
Wildlife and Ecotourism Contributions for Sustainable Natural Resource Management In and Around Bale Mountains National Park, Southeastern Ethiopia
Authors: Ertiban Sefi Mekonen , Maru Belay 
Published: October 2020

Abstract
Wildlife and ecotourism resources were assessed in and around Bale Mountains National Park (BMNP) to examine their contribution for sustainable use of natural resources which will improve the livelihood of local communities and conservation of park. Survey questionnaires, interview, field observation and literature reviews were employed to collect primary and secondary data. The analyses of the study revealed that natural and cultural resources such as abundance and diversity of mammals and birds, scenic landscape, cultural and historical attractions and some hotels or lodges at nearby areas are the main ecotourism potential in BMNP. The study also revealed some income generating alternatives or ecotourism potentials which could help to reduce the present degradations of natural resources of the park. About 37.2% of sampled households expressed their interests for diversified livelihood or ecotourism activities. Offering tourist facilities and services and creating job opportunities for members of local communities are the positive impacts of the tourism activities whereas, cutting trees, occurrences of seasonality and leakages are the negative impacts. Reinforcing existing off-agricultural livelihoods, introducing additional alternative options or ecotourism are important strategic directions for sustainable management of natural resources for BMNP and related protected areas.
Professionals’ perceptions of the establishment of a specialized brief therapy unit in a district psychiatric centre - a qualitative study.
Authors: Markussen Hilde Våbenø , Aasdahl Lene , Rise Marit By 
Published: October 2020

Abstract
Background: Increasing mental health problems and scarce treatment resources put pressure on mental health services to make innovations in service provision, such as developing differentiated services adapted to different needs. One innovation in differentiated service provision is brief or short-term treatment to patients with moderate mental health problems. Implementing a new unit in an organization usually faces many potential barriers and facilitators, and knowledge on how the professionals providing the services perceive the implementation of innovative approaches in mental health services is scarce. The aim of this study was therefore to explore the professionals’ perceptions of how the establishment of a specialized brief therapy unit had affected the organization, especially the everyday work in the outpatient clinics. Methods: Eleven professionals, five men and six women, took part in individual interviews. All participants were between 40 and 60 years old and had leading or coordinating positions in the organization. Their professional backgrounds were within psychology, nursing and medicine, most of them specialists in their field. Data was analyzed according to Systematic text condensation Results: The professionals’ experiences represented four main themes: (1) The brief therapy unit was perceived as successful and celebrated. (2) The general outpatient clinics, on the other hand, were described as “forgotten”. (3) The establishment process had elucidated different views on treatment in the outpatient clinics - and had set off (4) a discussion regarding the criteria for prioritizing in mental health services. Conclusion: Providing targeted treatment to patients with moderate mental health problems, while having a concurrent aim to solve broader problems in mental health services, entails a discussion regarding resource use and the appropriate level of treatment provision. Professionals should be more involved when innovative efforts are implemented, and the criteria for success must be conceptualized and evaluated. Longitudinal research on the implementation of innovative efforts in the services should include professionals’ and service users’ perspectives.
WNK1&nbsp;Antagonist Decreased Sevoflurane-induced Neurotoxicity in HT22 Hippocampal Neurons via the WNK1/NKCC1 Signalling Pathway
Authors: Bai Ya-Fan , Li Wen-Jing , Zhang Li , Li Jun-Fa , An Li-Xin 
Published: October 2020

Abstract
Background: . The GABAAR plays an important role in the neurotoxicity caused by sevoflurane, but the mechanism of its regulation in this context is unknown. The present study aimed to reveal the WNK1/NKCC1 pathway as a regulator of the neurotoxicity caused by sevoflurane on the HT22 hippocampal neuron cell line. Methods: HT22 cultured hippocampal neurons were divided into three groups: control group, 4.1% sevoflurane treatment group for 6h, WNK-463 (specific antagonist of WNK1, 1µmol) + sevoflurane treatment group. Cell viability and the optimum concentration of WNK-463 were measured by MTS method. Cell apoptosis was detected by Tunel method, and the content of cleaved caspase-3 protein apoptosis factor was detected by Western blot. Pathway protein detection including the expression of WNK1, NKCC1 were detected. Calcium imaging measures intracellular calcium ion concentration and verifies downstream targets.Results: The neurotoxic effects of sevoflurane on hippocampal neurons were observed. As setting the results of control group is “1”, compared with sevoflurane group, WNK-463 downregulated the protein expression of cleaved caspase-3 (1.96±0.49 vs 1.29±0.38), increased cell viability (0.68 vs 0.96) and decreased apoptosis (13.31±4.67/vision vs 7.05±3.82/vision, ***P < 0.001). Compared with the control group, sevoflurane treatment increased the expression of WNK1 kinase and NKCC1 protein, whereas WNK-463 reversed this increase without affecting the control HT22 cells (****P < 0.0001). Compared with the control group, sevoflurane exposure in HT22 cells increased intracellular Ca2+ concentrations, while WNK-463 reversed this change (1.0 vs 2.08±1.36 vs 1.26±0.77, **P < 0.01). Conclusion: This study demonstrated a neuroprotective role of the WNK1 antagonist WNK-463 in sevoflurane-induced neurotoxicity. WNK-463 promoted hippocampal neuron viability and reduced the apoptosis and intracellular calcium overload caused by sevoflurane on HT22 hippocampal neurons, possibly via the modulation of the WNK1/NKCC1 pathway.
Medication-related problems among hospitalized pregnant women in a tertiary teaching hospital in Ethiopia: A prospective observational study
Authors: AHMED SEID MUSSA , Sundby Johanne , Aragaw Yesuf Ahmed , Nordeng Hedvig 
Published: October 2020

Abstract
Background Studies on medication-related problems (MRPs) among pregnant women are scarce, despite the potential consequences for both mother and child. This study aimed to describe the prevalence, clinical significance, and risk factors for MRPs among hospitalized pregnant or postpartum women at Jimma University Medical Centre (JUMC) in Ethiopia. Methods A prospective follow-up and clinical audit of 1,117 hospitalized pregnant or postpartum women in the maternity and gynaecology wards at JUMC was carried out between February and June 2017. Patients were followed throughout their stay in the hospital to assess the presence and development of MRPs. Pre-tested data extraction form and an interview-guided structured questionnaire were used to collect data. Descriptive statistics were used to describe MRPs. Logistic regression analysis was used to identify factors associated with MRPs. Results One or more MRPs occurred among 323 (28.9%) study participants, mostly in relation to lack of iron supplementation. A total of 278 (70.6%) of all MRPs were considered to be of moderate to high clinical significance. When excluding MRPs due to iron from the analysis, chronic disease (adjusted OR 1.91; 95% CI 1.02, 3.58), medication use prior to admission (adjusted OR 2.38; 95% CI 1.24, 4.56), nulliparity (adjusted OR 1.99; 95% CI 1.22, 3.24) and multiparity (adjusted OR 1.91; 95% CI 1.17, 3.12) were significantly associated with experiencing an MRP. Conclusions Nearly 3 out of 10 hospitalized pregnant women at JUMC had one or more MRPs. The need for additional iron therapy was by far the most common type of MRP. Improved adherence to guidelines on iron supplementation are required. Multidisciplinary approaches including physicians, nurses, anesthesia professionals and clinical pharmacists in the maternity and gynaecology wards could possibly prevent MRPs and promote patient safety for women and children.
Clinical effect of minimally invasive surgery for inguinal cryptorchidism
Authors: Wang Yunjin , Chen Liu , Cui Xu , Zhou Chaoming , Zhou Qing , Zhang Zhengmian 
Published: October 2020

Abstract
Background: The purpose of this study was to investigate the clinical effect of minimally invasive surgery for inguinal cryptorchidism.Methods: The patients were divided into the minimally invasive surgery group (n=100) and the traditional surgery group (n=58). In the minimally invasive surgery group, patients with low inguinal cryptorchidism (n=54) underwent surgery with a transscrotal incision, and patients with high inguinal cryptorchidism (n=46) underwent laparoscopic surgery.Results: For low inguinal cryptorchidism, the operative duration in the minimally invasive surgery group was significantly shorter than that in the traditional surgery group (P<0.05). For high inguinal cryptorchidism, there was no difference in the operative duration, the postoperative hospital stay duration or hospital costs between the two groups (P>0.05). Additionally, there were no cases of testicular atrophy, testicular retraction, inguinal hernia or hydrocele in either group. There was no significant difference in the incidence of poor wound healing between the two groups (P>0.05). Although there was no significant difference in the incidence of scrotal hematoma between the two groups (P>0.05), the incidence in the minimally invasive surgery group was higher than that in the traditional surgery group.Conclusions: Minimally invasive surgery including a transscrotal incision for low inguinal cryptorchidism and laparoscopic surgery for high inguinal cryptorchidism is as safe and effective as traditional surgery, and could also provide a good cosmetic effect for children.
Comparison of Methylation Capture Sequencing and Infinium EPIC Methylation Array in Peripheral Blood Mononuclear Cells
Authors: Shu Chang , Zhang Xinyu , Aouizerat Bradley E. , Xu Ke 
Published: October 2020

Abstract
Background: Epigenome-wide association studies (EWAS) have been widely applied to identify methylation CpG sites associated with human disease. To date, the Infinium Methylation EPIC array (EPIC) is commonly used for high-throughput DNA methylation profiling. However, the EPIC array covers only 30% of the human methylome. Methylation Capture bisulfite sequencing (MC-seq) captures target regions of methylome and has advantages of extensive coverage in the methylome at an affordable price. Methods: Epigenome-wide DNA methylation in four peripheral blood mononuclear cell samples was profiled by using SureSelectXT Methyl-Seq for MC-seq and EPIC platforms separately. CpG site-based reproducibility of MC-seq was assessed with DNA sample inputs ranging in quantity of high (> 1000ng), medium (300-1000ng), and low (150ng-300ng). To compare the performance of MC-seq and the EPIC arrays, we conducted a Pearson correlation and methylation value difference at each CpG site that was detected by both MC-seq and EPIC. We compared the percentage and counts in each CpG island and gene annotation between MC-seq and the EPIC array. Results: After quality control, an average of 3,708,550 CpG sites per sample was detected by MC-seq with DNA quantity >1000ng. Reproducibility of MC-seq detected CpG sites was high with strong correlation estimates for CpG methylation among samples with high, medium, and low DNA inputs (r > 0.96). The EPIC array captured an average of 846,464 CpG sites per sample. Compared with the EPIC array, MC-seq detected more CpGs in coding regions and CpG islands. Among the 472,540 CpG sites captured by both platforms, methylation of a majority of CpG sites was highly correlated in the same sample (r: 0.98~0.99). However, methylation for a small proportion of CpGs (N=235) differed significantly between the two platforms, with differences in beta values of greater than 0.5. Conclusions: Our results show that MC-seq is an efficient and reliable platform for methylome profiling with a broader coverage of the methylome than the array-based platform. Although methylation measurements in majority of CpGs are highly correlated, a number of CpG sites show large discrepancy between the two platforms, which warrants further investigation and needs cautious interpretation.
Can voucher scheme enhance primary care provision for older adults: cross-sectional study in Hong Kong
Authors: Cheung Johnny , Wong Samuel Y.S. , Chan Dicken C. C. , Zhang Dexing , Luk Lawrence H.F. , Chau Patsy Y.K. , Yip Benjamin H.K. , Lee Eric K.P. , Wong Eliza L.Y. , Yeoh E.K. 
Published: October 2020

Abstract
Background The Hong Kong government has launched the Elderly Health Care Voucher (EHCV) scheme to facilitate primary care in the private sector for older adults. This study aimed to examine whether voucher use was associated with a shift of healthcare burden from the public to the private sector, vaccine uptake and continuity of care.Methods This cross-sectional survey recruited older adults with ≥3 chronic diseases through convenience sampling from seven general outpatient clinics, seven geriatric day hospitals, and five specialist outpatient clinics of the public healthcare sector in Hong Kong. We used multiple logistic regression to address the study objective.Results A total of 1032 patients participated in the survey. We included 714 participants aged 70 or above in the analysis. EHCV use was associated with higher utilization of private primary care services, including general practitioner and family doctor (Adjusted Odds Ratio (AOR) 2.67, 95% Confidence Interval (95%CI) 1.51–4.72) and Chinese medicine clinic (AOR 3.53, 95%CI 1.47–8.49). There were no significant associations of EHCV use with public general outpatient clinic attendance, Accident & Emergency attendance, and hospitalization. Furthermore, EHCV users were more likely to receive pneumococcal vaccination (AOR 2.17, 95%CI 1.22–3.85) and were less likely to visit the same doctors for chronic disease management (AOR 0.10, 95%CI 0.01–0.73).Conclusions While the EHCV may promote private primary care utilization and preventive care, older patients continue to rely on public services and the EHCV may worsen continuity of care. Policy-makers should designate voucher usage for chronic disease management and continuity of care.
Surgical treatment of 125 cases of congenital diaphragmatic eventration in a single institution
Authors: Zhao Shengliang , Pan Zhengxia , Li Yonggang , An Yong , Zhao Lu , Jin Xin , Fu Jian , Wu Chun 
Published: October 2020

Abstract
Background: This study sought to investigate the clinical characteristics of congenital diaphragmatic eventration (CDE) and to compare the efficacies of thoracoscopy and traditional open surgery in infants with CDE.Methods: We retrospectively analyzed the clinical data of 125 children with CDE (90 boys, 35 girls; median age: 12.2 months, range: 1 h-7 years; body weight: 1.99-28.5 kg, median body weight: 7.87±4.40 kg) admitted to our hospital in the previous 10 years,　and we statistically analyzed their clinical manifestations and surgical methods.Results: A total of 108 children in this group underwent surgery, of whom 67 underwent open surgery and 41 underwent thoracoscopic diaphragmatic plication. A total of 107 patients recovered well postoperatively, except for 1 patient who died due to respiratory distress after surgery. After 1-9.5 years of follow-up, 107 patients had significantly improved preoperative symptoms. During follow-up, the location of the diaphragm was normal, and no paradoxical movement was observed. Eleven of the 17 children who did not undergo surgical treatment did not have a decrease in diaphragm position after 1-6 years of follow-up. The index data on the operation time, intraoperative blood loss, chest drainage time, postoperative mechanical ventilation time, postoperative hospital stay and postoperative CCU admission time were better in the thoracoscopy group than in the open group. The difference between the two groups was statistically significant (P<0.05).Conclusions: The clinical symptoms of congenital diaphragmatic eventration vary in severity. Patients with severe symptoms should undergo surgery. Both thoracoscopic diaphragmatic plication and traditional open surgery can effectively treat congenital diaphragmatic eventration, but compared with open surgery, thoracoscopic diaphragmatic plication has the advantages of a short operation time, less trauma, and a rapid recovery.　Thus, thoracoscopic diaphragmatic plication should be the first choice for children with congenital diaphragmatic eventration.