bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic sentinel node navigation surgery versus laparoscopic gastrectomy with lymph node dissection for early gastric cancer: short-term outcomes of a multicentre randomized controlled trial (SENORITA)
Authors: An J Y , Min J-S , Hur H , Lee Y J , Cho G S , Park Y-K , Jung M R , Park J-H , Hyung W J , Jeong S-H , Kim Y-W , Yoon H M , Eom B W , Kook M-C , Han M R , Nam B-H , Ryu K W 
Published: June 2020

Abstract

Background
Sentinel node navigation surgery reduces the extent of gastric and lymph node dissection, and may improve quality of life. The benefit and harm of laparoscopic sentinel node navigation surgery (LSNNS) for early gastric cancer is unknown. The SENORITA (SEntinel Node ORIented Tailored Approach) trial investigated the pathological and surgical outcomes of LSNNS compared with laparoscopic standard gastrectomy (LSG) with lymph node dissection.

Methods
The SENORITA trial was an investigator-initiated, open-label, parallel-assigned, non-inferiority, multicentre RCT conducted in Korea. The primary endpoint was 3-year disease-free survival. The secondary endpoints, morbidity and mortality within 30 days of surgery, are reported in the present study.

Results
A total of 580 patients were randomized to LSG (292) or LSNNS (288). Surgery was undertaken in 527 patients (LSG 269, LSNNS 258). LSNNS could be performed according to the protocol in 245 of 258 patients, and a sentinel node basin was detected in 237 (96·7 per cent) Stomach-preserving surgery was carried out in 210 of 258 patients (81·4 per cent). Postoperative complications occurred in 51 patients in the LSG group (19·0 per cent) and 40 (15·5 per cent) in the LSNNS group (P = 0·294). Complications with a Clavien–Dindo grade of III or higher occurred in 16 (5·9 per cent) and 13 (5·0 per cent) patients in the LSG and LSNNS groups respectively (P = 0·647).

Conclusion
The rate and severity of complications following LSNNS for early gastric cancer are comparable to those after LSG with lymph node dissection. Registration number: NCT01804998 (http://www.clinicaltrials.gov).
Short‐ And medium‐term outcomes of reduced‐port laparoscopic surgery in elderly patients with upper rectal cancer: A retrospective cohort study
Authors: Wu Huawen , Zheng Zhijian , Xu Lewei , Wu Yingying , Guan Ziyi , Li Wenhuan , Chen Guofu 
Published: June 2020

ABSTRACTBackgroundTo investigate the short‐ and medium‐term outcomes of using a reduced‐port laparoscopic surgery (RPLS), compared to multi‐port laparoscopic surgery (MPLS), for the treatment of upper rectal cancer (URC) among elderly patients.MethodsWe conducted a retrospective analysis of the clinical and follow‐up data of 181 elderly patients with URC, who underwent radical laparoscopic surgery at our hospital, between January 2015 and January 2019. Among these 181 cases, 62 underwent RPLS and 119 MPLS.ResultsCompared to MPLS, RPLS decreased the length of surgical incision, lower pain on postoperative days 1 and 2, decreased the time to first flatus after surgery, as well as the time to mobilization after surgery. There was no difference between the short‐term outcomes between the two laparoscopic approaches, and no difference in the 3‐year disease‐free and overall survival rate.ConclusionCompared to MPLS, RPLS provides several advantages for the treatment of URC among elderly individuals, including a shorter length of surgical incision, reduced postoperative pain, shorter time to first flatus after surgery, earlier mobilization, and better cosmetic outcomes. These advantages are achieved with no difference in the length of surgery, nor in the 3‐year disease‐free and overall survival rate, compared to MPLS.
Comprehensive analysis of RNA binding motif protein 3 (RBM3) in non‐small cell lung cancer
Authors: Salomonsson Annette , Micke Patrick , Mattsson Johanna S. M. , La Fleur Linnea , Isaksson Johan , Jönsson Mats , Nodin Björn , Botling Johan , Uhlén Mathias , Jirström Karin , Staaf Johan , Planck Maria , Brunnström Hans 
Published: June 2020

AbstractAimsHigh expression of the RNA‐binding motif protein 3 (RBM3) correlates with improved prognosis in several major types of cancer. The aim of the present study was to examine the prognostic value of RBM3 protein and mRNA expression in non‐small cell lung cancer (NSCLC).Methods and resultsImmunohistochemical expression of RBM3 was evaluated in surgically treated NSCLC from two independent patient populations (n = 213 and n = 306). Staining patterns were correlated with clinicopathological parameters, overall survival (OS), and recurrence‐free interval (RFI). Cases with high nuclear RBM3 protein expression had a prolonged 5‐year OS in both cohorts when analyzing adenocarcinomas separately (P = .02 and P = .01). RBM3 remained an independent prognostic factor for OS in multivariable analysis of cohort I (HR 0.44, 95% CI 0.21‐0.90) and for RFI in cohort II (HR 0.38, 95% CI 0.22‐0.74). In squamous cell carcinoma, there was instead an insignificant association to poor prognosis. Also, the expression levels of RBM3 mRNA were investigated in 2087 lung adenocarcinomas and 899 squamous cell carcinomas assembled from 13 and 8 public gene expression microarray datasets, respectively. The RBM3 mRNA levels were not clearly associated with patient outcome in either adenocarcinomas or squamous cell carcinomas.ConclusionsThe results from this study support that high protein expression of RBM3 is linked to improved outcome in lung adenocarcinoma.
Measuring Electrochemical Surface Area of Nanomaterials versus the Randles−Ševčík Equation
Authors: Paixão Thiago R. L. C. 
Published: June 2020

AbstractThis Viewpoint article is to call the attention of the nanomaterials community to a standard error when using the Randles−Ševčík equation to calculate the electrode surface area, as this error is continuously reported in the literature and the idea is to complete the conversation about the critical discussion based on the duality of electrocatalytic performance of nanomaterials and surface area in order to understand the electrocatalytic effect of these materials and not to simply attribute the current enhancement on the basis of an increase in surface area.
Design and construction of a three‐dimensional electrode with biomass‐derived carbon current collector and water‐soluble binder for high‐sulfur‐loading lithium‐sulfur batteries
Authors: Wang Pengfei , Gong Zhe , Ye Ke , Kumar Vipin , Zhu Kai , Sha Linna , Yan Jun , Yin Jinling , Cheng Kui , Wang Guiling , Cao Dianxue 
Published: June 2020

AbstractLithium‐sulfur batteries attract lots of attention due to their high specific capacity, low cost, and environmental friendliness. However, the low sulfur utilization and short cycle life extremely hinder their application. Herein, we design and fabricate a three‐dimensional electrode by a simple filtration method to achieve a high‐sulfur loading. Biomass porous carbon is employed as a current collector, which not only enhances the electronic transport but also effectively limits the volume expansion of the active material. Meanwhile, an optimized carboxymethyl cellulose binder is chosen. The chemical bonding restricts the shuttle effect, leading to improved electrochemical performance. Under the ultrahigh sulfur load of 28 mg/cm2, the high capacity of 18 mAh/cm2 is still maintained, and stable cycling performance is obtained. This study demonstrates a viable strategy to develop promising lithium‐sulfur batteries with a three‐dimensional electrode, which promotes sulfur loading and electrochemical performance.
Triphenylphosphine‐Based Covalent Organic Frameworks and Heterogeneous Rh‐P‐COFs Catalysts
Authors: Liu Yubing , Dikhtiarenko Alla , Xu Naizhang , Sun Jiawei , Tang Jie , Wang Kaiqiang , Xu Bolian , Tong Qing , Heeres Hero Jan , He Songbo , Gascon Jorge , Fan Yining 
Published: June 2020

AbstractThe synthesis of phosphine‐based functional covalent organic frameworks (COFs) has attracted great attention recently. Herein, we present two examples of triphenylphosphine‐based COFs (termed P‐COFs) with well‐defined crystalline structures, high specific surface areas, and good thermal stability. Furthermore, rhodium catalysts with these P‐COFs as support material show high turnover frequency for the hydroformylation of olefins, as well as excellent recycling performance. This work not only extends the phosphine‐based COF family, but also demonstrates their application in immobilizing homogeneous metal‐based (e.g., Rh‐phosphine) catalysts for application in heterogeneous catalysis.
Bioorthogonal Phosphorogenic Rhenium(I) Polypyridine Sydnone Complexes for Specific Lysosome Labeling
Authors: Shum Justin , Zhang Pei‐Zhi , Lee Lawrence Cho‐Cheung , Lo Kenneth Kam‐Wing 
Published: June 2020

AbstractInvited for this month's cover is the group of Prof. Kenneth Kam‐Wing Lo at City University of Hong Kong, Hong Kong, P. R. China. The cover picture shows the selective landing of a bioorthogonal spacecraft on a lysosomal planet modified with a strained cyclooctyne moiety in an intracellular environment with other organelles and a plethora of biomolecules. A sydnone moiety is appended to a luminescent rhenium(I) diimine unit as both an emission quencher and a bioorthogonal handle. Selective strain‐promoted sydnone–alkyne cycloaddition (SPSAC) of the complex with a strained alkyne leads to impressive emission turn‐on, which can be exploited in bioimaging and phototherapeutic applications. Read the full text of the article at 10.1002/cplu.202000029.
Wild emmer chromosome arm substitution lines: Useful resources for wheat genetic study and breeding
Authors: Yu Jinsheng , Zhao Yanhao , Ding Mingquan , Yu Zitong , Jiang Yurong , Ma Wujun , Rong Junkang 
Published: June 2020

AbstractAs the progenitor of durum wheat (Triticum durum Desf.) and common wheat (T. aestivum L.), wild emmer wheat (T. turgidum L. subsp. dicoccoides, TTD) has many valuable alleles for enlarging the genetic pool of common wheat. Chromosome arm substitution lines (CASLs) are useful genetic resources producing genome‐wide variations in the background of certain cultivars, with each CASL containing a pair of an individual chromosome arms from the donor parent. Therefore, CASLs can be used to identify a broad range of phenotypes that are usually different from the parental lines, to map causal genes or quantitative trait loci and to broaden the genetic pools of existing cultivars as prebreeding materials. In this review we summarize recent progress in wheat genetic studies and breeding using two sets of CASLs of the wild emmer accession TTD140 in two common wheat backgrounds of ‘Chinese Spring’ and ‘Bethlehem’. We report the production of CASLs, confirmation of their chromosome structure using molecular markers, and their application in discovering and mapping agronomically important genes. We propose that, together with the release of high‐quality reference genomes of wild emmer and common wheat, wild emmer CASLs are useful resources for genetic study and breeding of wheat.
Analysis of FGF20‐regulated genes in organ of Corti progenitors by translating ribosome affinity purification
Authors: Yang Lu M. , Stout Lisa , Rauchman Michael , Ornitz David M. 
Published: June 2020

AbstractBackgroundUnderstanding the mechanisms that regulate hair cell (HC) differentiation in the organ of Corti (OC) is essential to designing genetic therapies for hearing loss due to HC loss or damage. We have previously identified Fibroblast Growth Factor 20 (FGF20) as having a key role in HC and supporting cell differentiation in the mouse OC. To investigate the genetic landscape regulated by FGF20 signaling in OC progenitors, we employ Translating Ribosome Affinity Purification combined with Next Generation RNA Sequencing (TRAPseq) in the Fgf20 lineage.ResultsWe show that TRAPseq targeting OC progenitors effectively enriched for RNA from this rare cell population. TRAPseq identified differentially expressed genes (DEGs) downstream of FGF20, including Etv4, Etv5, Etv1, Dusp6, Hey1, Hey2, Heyl, Tectb, Fat3, Cpxm2, Sall1, Sall3, and cell cycle regulators such as Cdc20. Analysis of Cdc20 conditional‐null mice identified decreased cochlea length, while analysis of Sall1‐null and Sall1‐ΔZn2‐10 mice, which harbor a mutation that causes Townes‐Brocks syndrome, identified a decrease in outer hair cell number.ConclusionsWe present two datasets: genes with enriched expression in OC progenitors, and DEGs downstream of FGF20 in the embryonic day 14.5 cochlea. We validate select DEGs via in situ hybridization and in vivo functional studies in mice.
A virtual issue highlighting animal studies of eating disorders as valuable tools for examining neurobiological underpinnings and treatment of eating disorders
Authors: Fowler Natasha , Klump Kelly L. 
Published: June 2020

AbstractWhile studies in humans suggest a role for psychosocial factors as well as biological and genetic processes in the development of eating disorders, the specific etiologic mechanisms remain largely unknown. In this virtual issue, we present a collection of 14 archived articles from the International Journal of Eating Disorders to highlight the utility of animal studies of eating disorders to advance our understanding of eating disorder etiology. Selected articles establish animal studies as valid tools to study disordered eating behavior, offer insight into potential neurobiological mechanisms, and highlight novel targets for future pharmacological treatments. Clinical implications of each article's findings are included to demonstrate the translational value of animal studies for the eating disorders field. We hope that the exciting concepts and findings in this issue inspire future animal studies of eating disorders.
Antimony‐based nanomaterials for high‐performance potassium‐ion batteries
Authors: Gao Hong , Guo Xin , Wang Shijian , Zhang Fan , Liu Hao , Wang Guoxiu 
Published: June 2020

AbstractPotassium‐ion batteries (PIBs) present great potential for large‐scale energy storage applications owing to their high energy density and the abundance of potassium reserve. However, the large radius of K+ and super‐reactive metallic nature of potassium make it difficult to realize electrochemically reversible storage with most conventional electrode materials. Currently, it remains a great challenge to develop appropriate anode materials with high specific capacities, long cycle life, and low cost for PIBs. Antimony‐based materials are recognized as a promising anode candidate because of their high theoretical capacities, appropriate potassiation potential, and relatively low cost. Herein, we review the recent progress of antimony‐based anode materials for PIBs, including metallic antimony, antimony‐based alloys, antimony chalcogenides, and composite combinations. Meanwhile, this review also focuses on the electrochemical reaction mechanisms, strategies for design and synthesis of electrode materials, and the advances of electrolyte modulation and electrode formulation. Finally, we present the critical challenges to be addressed and perspectives for ways forward to promote the development of PIBs.image
Nanobiopesticides: Silica nanoparticles with spiky surfaces enable dual adhesion and enhanced performance
Authors: Zhang Jun , Brown Geoff , Fu Jianye , James Peter , Mukandiwa Lillian , Huang Xiaodan , Yu Chengzhong 
Published: June 2020

AbstractBiopesticides, such as spinosad, are a new‐generation of ecofriendly pesticides in livestock industry. However, spinosad suffers from short duration of effectiveness and low potency in field conditions. Herein we report the development of a new nanospinosad design with dual adhesion and protection functions. Silica nanoparticles with spiky nanotopography loaded with spinosad possess rough surfaces. When applied topically, this nanospinosad formulation exhibited enhanced adhesion to both cattle hair and pest surface. The dual adhesion property led to significantly higher pest mortality toward tick (Rhipicephalus microplus, an ectoparasite) than a nanospinosad formulation using nanoparticles with smooth surface and a benchmark commercial product. The adhesion performance was further quantitatively measured using rainfastness test. Moreover, solar radiation test revealed that the nanospinosad exhibited >10 times higher photostability over the commercial product. This work paves the way toward the development of high performance nanobiopesticides for sustainable agricultural applications.image
Characteristics of imbibition in tight oil reservoirs from the perspective of physical experiments and theory
Authors: Cao Renyi , Wu Zhiyu , Liang Xiaowei , Cheng Linsong , Xu Zhongyi , Guan Yun , Guo Zhuoliang , Jia Zhihao 
Published: June 2020

AbstractImbibition is an important recovery mechanism for tight oil reservoirs, which occurs during hydraulic fracturing and development. Due to the massive distribution of micro‐nano scale pore throats and the existence of a boundary layer in tight formation, agreement consensus has not been reached on the imbibition mechanism. Based on the effect of the boundary layer, experiments were conducted to study the imbibition in tight sandstone, and NMR was used to determine the efficiency of imbibition. The results reveal that the imbibition rate is related to the connection area of the matrix‐fracture, throat connection, and radius. Then, the effective capillary pressure was modified by describing the thickness of the boundary layer in the micro‐nano pore throats. The calculation results show that the existence of boundary layer in micro‐nano throats makes the capillary pressure much larger than those of reservoirs without boundary layer. And the boundary layer reduces the effective flow radius, which dramatically decreases the imbibition quantity. The final result of existence of a boundary layer dramatically weakens the imbibition ability of a tight oil reservoir, and thus, the existence of a boundary layer cannot be ignored. Finally, the effective throat radius limit was analyzed during imbibition in a water‐oil‐rock system of a tight oil reservoir. Without a boundary layer, the effective radius of the pore throats in the water‐oil‐rock system during imbibition is greater than 200 nm, which is due to the advantages of the large capillary force and pore throats that are not too small. With a boundary layer, the main radius of the pore throats used for the water‐oil‐rock imbibition is approximately 400 nm. Thus, the imbibition occurs in the pore throats larger than 200 nm in the water‐oil‐rock system, and a surfactant could reduce the limit of the throat radius during imbibition in tight oil reservoirs.
Social exclusion modulates dual mechanisms of cognitive control: Evidence from ERPs
Authors: Xu Mengsi , Li Zhiai , Qi Senqing , Fan Lingxia , Zhou Xiaolin , Yang Dong 
Published: June 2020

AbstractMany studies have investigated how social exclusion influences cognitive control but reported inconsistent findings. Based on the dual mechanisms of control framework, this study investigated how social exclusion influences proactive and reactive modes of control (Experiment 1) and the underlying mechanisms (Experiment 2). The Cyberball game was used to manipulate social exclusion. Eighty‐six female participants (about 40 for each experiment) performed cognitive control tasks while event‐related potentials were recorded. In Experiment 1, an AX Continuous Performance Task (AX‐CPT) was adopted to differentiate between proactive and reactive control. Results showed that social exclusion weakened proactive control but enhanced reactive control, as reflected by the weaker proactive control indicators (i.e., P3b and CNV), but strengthened reactive control indicators (accuracy and N2) in excluded individuals. More importantly, in Experiment 2, through varying in whether task cues were available before or after target onset in a cued‐flanker task, we further manipulated the possibility of engaging proactive control, and found the weakened proactive control could be attributed to both impaired cognitive ability and lowered motivation to engage proactive control in excluded individuals. Together, these results provide insight on how social exclusion influences cognitive control and suggest promising implications for designing effective interventions to relieve the negative impact of social exclusion.
Negative illness perceptions are related to poorer health‐related quality of life among thyroid cancer survivors: Results from the PROFILES registry
Authors: Schoormans Dounya , Wijnberg Laura , Haak Harm , Husson Olga , Mols Floortje 
Published: June 2020

AbstractBackgroundDifferentiated thyroid cancer (DTC) reports a poorer health‐related quality of life (HRQoL) than a norm population. Patients' illness perceptions are modifiable and known associates of HRQoL in other cancers. The aim was to examine the relationship between illness perceptions and HRQoL among DTC survivors.MethodsDTC survivors registered in the Netherlands Cancer Registry diagnosed between 1990 and 2008, received a survey on illness perceptions (Brief‐Illness Perception Questionnaire; B‐IPQ) and HRQoL (European Organisation for Research and Treatment of Cancer, Quality of Life Questionnaire‐Core 30; EORTC QLQ‐C30). Multiple regression analyses were conducted investigating the relation between illness perceptions and HRQoL, while controlling for sociodemographic and clinical characteristics.ResultsTwo hundred and eighty‐four DTC survivors were included. DTC survivors who believed their illness had many negative consequences; who perceived their illness as controllable by treatment; who had strong beliefs symptoms could be attributed to their illness; and who had strong beliefs their illness causes negative emotions, reported a poorer HRQoL.ConclusionsStronger negative illness perceptions are related to a poorer HRQoL among DTC survivors.
Identifying an Optimal Liver Frailty Index Cutoff to Predict Waitlist Mortality in Liver Transplant Candidates
Authors: Kardashian Ani , Ge Jin , McCulloch Charles E. , Kappus Matthew R. , Dunn Michael A. , Duarte‐Rojo Andres , Volk Michael L. , Rahimi Robert S. , Verna Elizabeth C. , Ganger Daniel R. , Ladner Daniela , Dodge Jennifer L. , Boyarsky Brian , McAdams‐DeMarco Mara , Segev Dorry L. , Lai Jennifer C. 
Published: June 2020

Background and Aims
Frailty, as measured by the Liver Frailty Index (LFI), is associated with liver transplant (LT) waitlist mortality. We sought to identify an optimal LFI cutoff that predicts waitlist mortality.

Approach and Results
Adults with cirrhosis awaiting LT without hepatocellular carcinoma at nine LT centers in the United States with LFI assessments were included. Multivariable competing risk analysis assessed the relationship between LFI and waitlist mortality. We identified a single LFI cutoff by evaluating the fit of the competing risk models, searching for the cutoff that gave the best model fit (as judged by the pseudo‐log‐likelihood). We ascertained the area under the curve (AUC) in an analysis of waitlist mortality to find optimal cutoffs at 3, 6, or 12 months. We used the AUC to compare the discriminative ability of LFI+Model for End Stage Liver Disease‐sodium (MELDNa) versus MELDNa alone in 3‐month waitlist mortality prediction. Of 1,405 patients, 37 (3%), 82 (6%), and 135 (10%) experienced waitlist mortality at 3, 6, and 12 months, respectively. LFI was predictive of waitlist mortality across a broad LFI range: 3.7‐5.2. We identified an optimal LFI cutoff of 4.4 (95% confidence interval [CI], 4.0‐4.8) for 3‐month mortality, 4.2 (95% CI, 4.1‐4.4) for 6‐month mortality, and 4.2 (95% CI, 4.1‐4.4) for 12‐month mortality. The AUC for prediction of 3‐month mortality for MELDNa was 0.73; the addition of LFI to MELDNa improved the AUC to 0.79.

Conclusions
LFI is predictive of waitlist mortality across a wide spectrum of LFI values. The optimal LFI cutoff for waitlist mortality was 4.4 at 3 months and 4.2 at 6 and 12 months. The discriminative performance of LFI+MELDNa was greater than MELDNa alone. Our data suggest that incorporating LFI with MELDNa can more accurately represent waitlist mortality in LT candidates.