bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mining machines accident problem solving via the Toyota A3 Report
Authors: Papić Ljubia , Gadolina I. V. , Panteli Milorad , Papić Neda 
Published: December 2019

The Aim of the paper is to show the advantages associated with the application of the Toyota A3 Report as a standard method of information exchange. It must be noted that as of today this method has not found widespread application. It deserves better. Using specific examples of accidents involving mining machines, the authors show how a Report is completed hoping that this information will help in the adoption of this system in other enterprises. That may contribute to the solution of many problems of industrial management. This paper will be most useful for operators of mining machines.TheMethodconsists in presenting material on an А3 sheet of paper, that is required in order to set forth all the information needed to solve a problem. Why the А3 format? A3 is the maximum size of a sheet of paper that can be faxed. Before the emergence of personal computers it was the most common tool of communication between Toyota Motor factories. The above example of application of the Toyota A3 Report contains such crucial sections as maintenance and reliability of mining machines, information on prior research, application of the “5 Why?” method and consideration of the human factor. In the example given in the paper, the report describes the circumstances of the accident involving the SRs 1200 24/4 (G2) excavator, that occurred on April 6, 1995 in the open-pit mine Field D, mining basin Kolubara by the Electric Power Industry of Serbia. The report also includes an estimate of the consequences and analysis of the causes of the accident.TheFindingsinclude the methodological approach to the solution of problems, brief format of information presentation, documentation and registration, so that other people involved in the process can review it; assuring the persons involved can form an idea of the operating procedures and outcome of problem resolution. A common language is provided for communication within the company along with a culture of Lean production. The А3 Report is a training process and foundation for future changes in the manufacturing process management.Conclusions.The Toyota A3 Report has two primary functions: submission of proposals and reporting on the approved measures per the submitted proposals. It allows strictly defining the problem and proceeding to the measures aimed at improving the situation. The practical application of the Report as part of communication within the company and with suppliers will enable quick and targeted solution of managerial problems. Initially developed in Japan within the Toyota company, the method currently finds wider application in Serbian enterprises and elsewhere.
Methods for Reducing Contrast Use and Avoiding Acute Kidney Injury During Endovascular Procedures
Authors: Vergadis Chrysovalantis , Festas Georgios , Spathi Eleni , Pappas Paris , Spiliopoulos Stavros 
Published: December 2019

:Iodinated Contrast Media (CM) has a plethora of applications in routine non-invasive or percutaneous invasive imaging examinations and therapeutic interventions. Unfortunately, the use of CM is not without complications, with contrast-induced acute kidney injury (CI-AKI) being among the most severe.:CI-AKI is a syndrome defined as a rapid development of renal impairment after a few days of CM endovascular injection, without the presence of any other underlying related pathologies. Although mostly transient and reversible, for a subgroup of patients with comorbidities related to renal failure, CI-AKI is directly leading to longer hospitalization, elevated rates of morbidity and mortality, as well as the increased cost of funding.:Thus, a need for classification in accordance with clinical and peri-procedural criteria is emerged. This would be very useful for CI-AKI patients in order to predict the ones who would have the greatest advantage from the application of preventive strategies.:This article provides a practical review of the recent evidence concerning CI-AKI incidence, diagnosis, and sheds light on prevention methods for reducing contrast use and avoiding AKI during endovascular procedures.:In conclusion, despite the lack of a specific treatment protocol, cautious screening, assessment, identification of the high-risk patients, and thus the application of simple interventions -concerning modifiable risk factors- can significantly reduce CI-AKI risk.
Synthesized 2-Trifluoromethylquinazolines and Quinazolinones Protect BV2 and N2a Cells against LPS- and H2O2-induced Cytotoxicity
Authors: Nallathamby Neeranjini , Phan Chia-Wei , Sova Matej , Saso Luciano , Sabaratnam Vikineswary 
Published: December 2019

Background:
Microglia are associated with neuroinflammation, which play a key role
in the pathogenesis of neurodegenerative diseases. It has been reported that some quinazolines and
quinazolinones possess anti-inflammatory properties. However, the pharmacological properties of
certain quinazoline derivatives are still unknown.

Objective:
The antioxidant, cytotoxic, and protective effects of a series of synthesized 2-
trifluoromethylquinazolines (2, 4, and 5) and quinazolinones (6-8) in lipopolysaccharide (LPS)-
murine microglia (BV2) and hydrogen peroxide (H2O2)-mouse neuroblastoma-2a (N2a) cells were
investigated.

Method:
The antioxidant activity of synthesized compounds was evaluated with ABTS and DPPH
assays. The cytotoxic activities were determined by MTS assay in BV2 and N2a cells. The production
of nitric oxide (NO) in LPS-induced BV2 microglia cells was quantified.

Results:
The highest ABTS and DPPH scavenging activities were observed for compound 8 with
87.7% of ABTS scavenge percentage and 54.2% DPPH inhibition. All compounds were noncytotoxic
in BV2 and N2a cells at 5 and 50 μg/mL. The compounds which showed the highest protective
effects in LPS-induced BV2 and H2O2-induced N2a cells were 5 and 7. All tested compounds,
except 4, also reduced NO production at concentrations of 50 μg/mL. The quinazolinone
series 6-8 exhibited the highest percentage of NO reduction, ranging from 38 to 60%. Compounds
5 and 8 possess balanced antioxidant and protective properties against LPS- and H2O2-induced cell
death, thus showing great potential to be developed into anti-inflammatory and neuroprotective
agents.

Conclusion:
Compounds 5 and 7 were able to protect the BV2 and N2a cells against LPS and
H2O2 toxicity, respectively, at a low concentration (5 μg/mL). Compounds 6-8 showed potent reduction
of NO production in BV2 cells.
Benzazole Substituted Iminocoumarins as Potential Antioxidants with Antiproliferative Activity
Authors: Perin Nataša , Cindrić Maja , Vervaeke Peter , Liekens Sandra , Mašek Tomislav , Starčević Kristina , Hranjec Marijana 
Published: December 2019

Background:Benzazole and coumarin derivatives are one of the most privileged heterocyclic substructures in the medicinal chemistry with well-known biological features, which include a wide range of versatile biological activities as well as excellent spectroscopic characteristics thus offering their potential application in many research fields.Objective:The prepared iminocoumarins were synthesized to evaluate their antioxidative potential by using ABTS and FRAP assays and in vitro antiproliferative activity.Method:A series of coumarin derivatives containing a 2-benzazole motif were synthesized and evaluated for their antioxidative capacity and antiproliferative activity. Their molecular structure incorporates a push-pull functionality: an electron donor donating group at the 7-position with an electron-withdrawing group, such as benzimidazole, benzothiazole and imidazopyridine fragment at the 3-position.Results:The iminocoumarins bearing different substituents on 7-position were evaluated for their antiproliferative activity on tree cancer cells with only 4 compounds showing the antiproliferative activity. The most active derivative was N,N-diethylamino substituted benzimidazole derivative 4d and imidazo[4,5-b]pyridine analogue 6b, both also displayed selective activity toward CEM with submicromolar inhibitory concentration (0.059 μM; 0.17 ± 0.09, respectively). The inhibitory effect of 4d and 6b derivatives on the cell-cycle progression of HeLa cells was studied. A flow cytometric analysis of the HeLa cells indicated an appreciable cell-cycle arrest in a dose-dependent manner. Antioxidant properties were studied by ABTS and FRAP assays and obtained results revealed that the most promising antioxidant has proven to be compound 3b while other compounds, in general, showed moderate to very low antioxidative capacity in both assays.Conclusion:Unsubstituted benzimidazole derivatives bearing hydroxyl group on iminocoumarin nuclei exhibited the most prominent antioxidant potential in ABTS assay (3b; 40.5 ± 0.01). The most significant and selective antiproliferative activity was displayed by compounds 4d and 6b (0.059 μM; 0.17 ± 0.09, respectively), which were chosen as lead compounds for further optimization and rational design to obtain more active and selective antiproliferative agents.
Wound Healing Management: A Systematic Approach Of Existing Treatment
Authors: Khan Azmi , Chaudhary Manupriya , Gupta Madhu 
Published: December 2019

:
Wound healing is an elaborated and vastly synchronized process that requires intricate coordination between many cell types with an appropriate extracellular microenvironment. The management of wounds represents a key research area due to the vital functional and aesthetic role of this tissue. An auspicious approach in the currently available treatment is the growth factors that imitate the micro environs and active vital regenerative pathways conducive to wound healing. An organized methodology to study, a multi-expert methodology to treatment and enthusiasm to study the patient’s perceptions are some of the principal amendments that have paralleled technical advances and know-how such as debridement, Negative Pressure Therapy, natural drugs etc. These methodologies may be seen as co-operative in wound healing. This article will review pathophysiology, discuss currently available treatment and novel approaches for treating a wound.
Low Complexity Adaptive Nonlinear Models for the Diagnosis of Periodontal Disease
Authors: Satpathy Anurag , Panda Ganapati , Gogula Rajasekhar , Sharma Renu 
Published: December 2019

Background / Objective:The paper addresses a specific clinical problem of diagnosis of periodontal disease with an objective to develop and evaluate the performance of low complexity Adaptive Nonlinear Models (ANM) using nonlinear expansion schemes and describes the basic structure and development of ANMs in detail.Methods:Diagnostic data pertaining to periodontal findings of teeth obtained from patients have been used as inputs to train and validate the proposed models.Results:Results obtained from simulations experiments carried out using various nonlinear expansion schemes have been compared in terms of various performance measures such as Mean Absolute Percentage Error (MAPE), matching efficiency, sensitivity, specificity, false positive rate, false negative rate and diagnostic accuracy.Conclusion:The ANM with seven trigonometric expansion scheme demonstrates the best performance in terms of all measures yielding a diagnostic accuracy of 99.11% compared to 94.64% provided by adaptive linear model.
An Enhanced Multiple Linear Regression Model for Seasonal Rainfall Prediction
Authors: Shaker Reddy Pundra Chandra , Sureshbabu Alladi 
Published: December 2019

Aims & Background:
India is a country which has exemplary climate circumstances
comprising of different seasons and topographical conditions like high temperatures, cold atmosphere,
and drought, heavy rainfall seasonal wise. These utmost varieties in climate make us exact
weather prediction is a challenging task. Majority people of the country depend on agriculture.
Farmers require climate information to decide the planting. Weather prediction turns into an orientation
in farming sector to deciding the start of the planting season and furthermore quality and
amount of their harvesting. One of the variables are influencing agriculture is rainfall.

Objectives & Methods:
The main goal of this project is early and proper rainfall forecasting, that
helpful to people who live in regions which are inclined natural calamities such as floods and it
helps agriculturists for decision making in their crop and water management using big data analytics
which produces high in terms of profit and production for farmers. In this project, we proposed
an advanced automated framework called Enhanced Multiple Linear Regression Model (EMLRM)
with MapReduce algorithm and Hadoop file system. We used climate data from IMD (Indian
Metrological Department, Hyderabad) in 1901 to 2002 period.

Results:
Our experimental outcomes demonstrate that the proposed model forecasting the rainfall with
better accuracy compared with other existing models.

Conclusion:
The results of the analysis will help the farmers to adopt effective modeling approach by
anticipating long-term seasonal rainfall.
Outage Analysis in Underlay OFDMA Based Cooperative Cognitive Radio Networks
Authors: Sawant Rupali , Nema Shikha 
Published: December 2019

Background:
Efficient resource allocation in Cooperative Cognitive Radio Network
(CCRN) is necessary in order to meet the challenges in future wireless networks. With proper resource
allocation, the Quality of Service (QoS) comprising of outage probability and data rate are
evaluated in this paper and sufficiently improved with proper subcarrier allocation.

Objective:
Another important parameter is Signal to Interference Ratio (SIR) which should be
above a threshold called minimum protection ratio to maintain the required QoS.

Results:
The network considered is Orthogonal Frequency Division Multiple Access (OFDMA)
based Hybrid Cooperative Cognitive Radio Network (HCCRN) in downlink in which licensed as
well as unlicensed resources are used by cognitive user depending on it’s availability keeping the
interference constraint in limit. The number of subcarriers required is different for every user depending
upon its distance from the base station to satisfy the requirement of data rate which depends
on the experienced SIR. To avoid outage of users at the boundary of a cell, it is necessary to
allocate more number of subcarriers.

Conclusion:
It is observed that for a given user position and outage probability, as the number of
subcarrier allocation in a subchannel increases high data rates can be achieved. This analysis can
be useful in allocation of subcarriers to users depending upon their position.
Scalability Analysis of Privacy Enabled IPv6 Addressing Protocol for Duty Cycled 6LoWPAN
Authors: Mavani Monali , Asawa Krishna 
Published: December 2019

Background:
The privacy enabled IPv6 addressing mechanism ensures the privacy of the
node's identification in the communication messages. It makes it difficult for adversaries to track nodes
and link any activities with the node's IP or the MAC address. Scalability of the privacy enabled IPv6
addressing scheme for 6LoWPAN may be affected due to underlying MAC layer mechanisms.

Objective:
Hence, this study aims to explore such an impact.

Methods:
Addressing scheme is implemented in the Contiki operating system which uses duty cycling
at the MAC layer along with the CSMA channel access mechanism. ContikiMAC and
CXMAC are widely used duty cycling protocols in Contiki. An analytical study is presented in
this paper, which analyses the IPv6 address configuration delay with ContikiMAC and CXMAC.
Simulation is performed to corroborate the presented analytical model. The address configuration
latency limits the scalability of the network. Hence, this paper studies the impact of duty cycling
of the nodes on the address configuration latency and estimates the size of a single hop PAN.

Results & Conclusion:
It is observed that the ContikiMAC duty cycling protocol can achieve better
performance compared to the CXMAC protocol in terms of address configuration latency. In
order to make up for the delay due to duty cycling, the network can be divided into multiple PANs
of smaller sizes where the addressing process runs simultaneously.
Enantiomeric Separation of Meclizine Hydrochloride in Pharmaceutical Dosage Form by HPLC Method
Authors: Gowramma Byran , Kumar Ramachandran Senthil , Kalirajan Rajagopal , Lakshmanan Kaviarasan , Meyyanathan Subramanian Nainar 
Published: December 2019

Objective:A basic, powerful and isocratic chiral fluid chromatographic technique was created and approved for the enantiomeric partition of meclizine hydrochloride in pharmaceutical dose structure.Methods:The chromatographic partition was accomplished on Phenomenex® Lux Cellulose 1 (250 mm x 4.6 mm i.d, 5 μm molecule size) section utilizing portable stage framework containing acetonitrile: 25mM ammonium bicarbonate (75:25%v /v). The versatile stage was siphoned on the segment at the stream pace of 1.0 mL/min, and UV recognition was done at 230 nm.Result:The breaking points of recognition and measurement were observed to be 0.25 μg/mL and 1.00 μg/mL individually, for 20μL infusion volume. The alignment bend demonstrated phenomenal linearity over the focus scope of 1-5 μg/mL for (±) meclizine enantiomers with a relationship coefficient (r2 = 0.999). The recuperation investigation of meclizine from tablet plan was observed to be 97.33% and 98.81% separately. Meclizine standard arrangement and versatile stage were observed to be steady for in any event 32h. The meclizine enantiomers were very much settled with mean maintenance times of about (+) Meclizine at 13.14 min and (-) Meclizine at 14.33 min individually.Conclusion:The created technique was broadly approved and demonstrated to be hearty, exact, exact and appropriate for the examination of meclizine enantiomers in tablet measurement structure and security investigations of meclizine.
A Comparative Review for Question Answering Frameworks on the Linked Data
Authors: Tasar Ceren O. , Komesli Murat , Unalir Murat O. 
Published: December 2019

Background:
One of the state-of-the-art techniques for question answering frameworks is
using linked data by converting the user input into SPARQL which is the query language for linked
data.

Objective:
The main target is to emphasize the most fundamental issues while developing a question
answering frameworks that accept input in natural language and converting it into SPARQL.

Methods:
The trend of applying linked data as a data source is gaining popularity among the researchers.
In this study, question answering frameworks that combine both natural language processing
techniques and linked data technologies are examined. Common principles of examined
question answering frameworks recognize user intention, enriching natural language input and converting
it to a SPARQL query.

Results:
9 studies are selected for further examination to be compared by using selection criteria defined
in the research methodology.

Conclusion:
Resulting outcomes are represented and compared in detail. In addition to the comparative
review of systems, a general architecture of question answering frameworks on the linked data
is drawn as an outcome of this study to provide a guideline for the researchers who are studying related
research fields.
Identifikasi Serovar Penyebab Leptospirosis pada Anjing di Yogyakarta
Authors: Mulyani Guntari Titik , Hartati Sri , Wuryastuty Hastari , Tjahajati Ida , Yuriadi Yuriadi , Widiyono Irkham , Yanuartono Yanuartono , Purnamaningsih Hary , Indarjulianto Soedarmanto , Raharjo Slamet , Nururozi Alfariza , Ganapragasam Angeline , Jiao Yeo Suan 
Published: December 2019

Leptospirosis is a zoonotic disease of global concern, and is caused by pathogenic serovar Leptospira interrogans. Canine Leptospirososis is widespread worldwide, dogs can act as incidental hosts or maintenance hosts for various serovars. The purpose of this research was to identify leptospire serovars that infect healthy and suspected leptospirosis dogs in Yogyakarta. A total of 56 dogs (36 healthy dogs and 20 suspect leptospirosis dogs) sera were taken from cephalica vein as much as 3 ml. Sera were examined for leptospirosis with Microscopic Aglutination Test (MAT) which conducted at the Research Center for Veterinary Science, Bogor. Microscopic Aglutination Test carried out on various Leptospire serovar, namely: Ichterohaemorrhagiae, Javanica, Celledoni, Ballum, Pyogenes, Cynopeteri, Rachmati, Australis, Pomona, Canicola, Grippotyphosa, Bataviae, Hardjo, and Tarrasovi. The results showed that Celledoni serovars infected 25% of healthy dogs and 5% of suspect leptospirosis dogs, Javanica serovar infected 19% of healthy dogs, Bataviae serovars infected 15% of suspect leptospirosis dogs, Grippotyphosa serovar infected 11% of healthy dogs, Tarrasovi serovar infected 10% of suspect leptospirosis dogs, serovars Cynopteri infects 5% of healthy dogs and 5% of suspect leptospirosis dogs, serovar Pyrogenes infects 5% of healthy dogs and 5% of suspect leptospirosis dogs, and serovar Rachmati infects 5% of suspect leptospirosis dogs. Seven healthy dogs (19%) and 2 suspect leptospirosis dogs (10%) were infected with more than 2 leptospire serovars. From the results of this study it can be concluded that Celledoni serovar of Leptospira interrogans infection causes subclinical leptospirosis, while Bataviae serovar infection causes clinical leptospirosis in dogs in Yogyakarta.
Seroprevalensi Penyakit Egg Drop Syndrome pada Itik di Desa Tumbak Bayuh, Kecamatan Mengwi, Badung, Bali
Authors: Kencana Gusti Ayu Yuniati , Kardena I Made , Shantika Pratistha Ni Wayan Apsari 
Published: December 2019

Egg Drop Syndrome can cause detrimental impacts on breeders due to reducing production and quality of theaffected eggs.This study aim was to determine the seroprevalece ofantibody against Egg Drop Syndrome (EDS) virus in ducks. Antibody titers examination was done from 75blood samplesof ducks thathave not been vaccinatedagainstEDS virus. The duck samples were collected from Tumbak Bayuh Village, Mengwi, Badung. Serological examination was held at the Virology Laboratory,Faculty of Veterinary Medicine, Udayana University by usingHaemagglutination Inhibition (HI) test. HI test results showed that 24 samples were positive contained antibody of the EDS,while 51 samples were negative. Range of EDS antibody titer observed was from24 to 27 HI units. This results indicates that the ducks have protective antibody titer against EDS virus. The positive serum samples were also tested using HI test against Newcastle Disease (ND) virus with negative result. It can be concluded that the ducks in Tumbak Bayuh Village, Mengwi, Badung have 32% of antibody titer against EDS virus whichmight result from being exposed by EDS virus naturally.
Inventarisasi Emisi Gas Rumah Kaca (CH4 dan N2O) Dari Sektor Peternakan Sapi Dengan Metode Tier-1 IPCC di Kabupaten Muaro Jambi
Authors: Syarifuddin Hutwan , Sy A Rahman , Devitriano Dodi 
Published: December 2019

Gas rumah kaca (GRK) dalam bentuk CH4 dan N2O memberikan kontribusi terhadap pemanasan global. Sektor pertanian menyumbang 10-12% dari total GRK antropogenik dari gas CH4 dan N2O. Sedangkan sektor peternakan menyumbang sekitar 18-51% GRK antropogenik. Penelitian bertujuan untuk menganalisis beban emisi gas CH4 dan N2O bersumber dari Peternakan terhadap GRK Di Kabupaten Muara Jambi yang diestimasi dengan menggunakan metode Tier-1 IPCC. Pada metode ini data yang diperlukan adalah populasi ternak dalam satu tahun 2018 dan nilai faktor emisi (FE) setiap gas GRK menurut buku panduan IPCC (2006). Data populasi ternak sapi diambil dari buku statistic peternakan, sedangkan nilai FE diambil dari buku IPCC (2006). Hasil penelitian menunjukkan beban emisi gas CH4 dari fermentasi enterik 1,1227 Gg CH4/tahun, Emisi CH4 dari Pengelolaan kotoran 0,0239 Gg CH4/tahun, emisi N2O langsung dari pengelolaan kotoran 465,85 Kg N2O/tahun dan emisi N2O tidak langsung dari pengelolaan kotoran ternak 69,88 Kg N2O/tahun. Sektor peternakan telah berkontribusi terhadap pemanasan global yang bersumber dari gas CH4 dan NO2 baik dari fermentasi enterik maupun dari pengolaan kotoran ternak sapi.