bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of the Source Encryption Algorithm Model in the Power Industry
Authors: Longbing Jiao 
Published: January 2020

Abstract
With the development of Internet technology and Internet of Things technology, the Internet of Everything has become a hot topic, and in March 2019, the National Grid for the first time clarified the definition of the Pan-In Power Internet of Things, pointing out that the company’s most urgent and important task is to accelerate the construction of the Pan-In Power Internet of Things. The security of Data Transfer on-line at any time is particularly important, in order to ensure the security of data, in the process of data transmission, data needs to be encrypted. This paper expounds a model of the information source data encryption algorithm, analyzes the encryption algorithm and the encryption method, and then provides a reference basis for the data transmission data security of power system.
A Solution to Incompatibility Between IPv6 and IPv4 Communications
Authors: Ibrahim Omar Khaled Omar 
Published: January 2020

Abstract
It has been about one year since last hearing anything about the Internet Protocol v10 (IPv10) proposal while this week it’s now available in draft form. While IPv6 isn’t widely-adopted around the globe yet, IPv10 is already in development and helps to address some of the woes of IPv6. IPv10 is designed to allow IPv6 addresses to communicate to/from IPv4 addresses. IPv10 hopes to speed the adoption to IPv6 addressing by making it more backwards compatible with IPv4 with allowing the two Internet Protocol standards to better coexist.
From the draft specification: “It solves the issue of allowing IPv6 only hosts to communicate to IPv4 only hosts and vice versa in a simple and very efficient way, especially when the communication is done using both direct IP addresses and when using hostnames between IPv10 hosts, as there is no need for protocol translations or getting the DNS involved in the communication process more than its normal address resolution function. IPv10 allows hosts from two IP versions (IPv4 and IPv6) to be able to communicate, and this can be accomplished by having an IPv10 packet containing a mixture of IPv4 and IPv6 addresses in the same IP packet header.”
Philosophical Basis of the Compulsory Company Manpower Report toward Pancasila Industrial Relation
Authors: Sarira Iron 
Published: January 2020

The research aimed to find out the intrinsic meaning and pragmatic interests of the concept of Compulsory Company Manpower Report (CCMR) and how the principle basis of Law Number 7 Year 1981 affected philosophical validity in realizing industrial relation in accordance with Pancasila. The research applied a qualitative method with textual analysis. The media of research was CCMR, which was one of the minimum macro aspects (work norm) in labor inspection as regulated in Law Number 7 Year 1981 aiming to implement the policy of work opportunity expansion and work protection as mandated by Article 27 paragraph (1) of the 1945 Constitution. The results report the conditions of employment within a company having historical and meaningful substances as the 1945 Constitution states the existence of equality in law and government for every citizen, and each citizen shall uphold the law and government as a manifestation of an active role of citizenship. The applicability of a positive norm cannot be separated from its juridical, sociological, and philosophical requirements. Many opinions reveal that CCMR is only for operational administrative fulfillment. Meanwhile, there is a philosophical basis of CCMR that reaches to the idea about conceptions in work opportunity and labor protection to realize harmonious, dynamic, and fair industrial relations in accordance with Pancasila.
Functional Characterization of a Novel Hybrid Peptide with High Potency against Gram-negative Bacteria
Authors: Tall Yara Al , Al-Rawashdeh Baha’a , Abualhaijaa Ahmad , Almaaytah Ammar , Masadeh Majed , Alzoubi Karem H. 
Published: January 2020

Background:Multi-drug resistant infections are a growing worldwide health concern. There is an urgent need to produce alternative antimicrobial agents.Objective :The study aimed to design a new hybrid antimicrobial peptide, and to evaluate its antimicrobial activity alone and in combination with traditional antibiotics.Methods:Herein, we designed a novel hybrid peptide (BMR-1) using the primary sequences of the parent peptides Frog Esculentin-1a and Monkey Rhesus cathelicidin (RL-37). The positive net charge was increased, and other physicochemical parameters were optimized. The antimicrobial activities of BMR-1 were tested against control and multi-drug resistant gram-negative bacteria.Results:BMR-1 adopted a bactericidal behavior with MIC values of 25-30 µM. These values reduced by over 75% upon combination with conventional antibiotics (levofloxacin, chloramphenicol, ampicillin, and rifampicin). The combination showed strong synergistic activities in most cases and particularly against multi-drug resistance P. aeruginosa and E. coli. BMR-1 showed similar potency against all tested strains regardless of their resistant mechanisms. BMR-1 exhibited no hemolytic effect on human red blood cells with the effective MIC values against the tested strains.Conclusion:BMR-1 hybrid peptide is a promising candidate to treat resistant infectious diseases caused by gramnegative bacteria.
Flavonoids as Multi-Target Compounds: A Special Emphasis on their Potential as Chemo-adjuvants in Cancer Therapy
Authors: Namdeo Ajay G. , Boddu Sai H.S. , Amawi Haneen , Ashby Charles R. , Tukaramrao Diwakar B. , Trivedi Piyush , Babu R. Jayachandra , Tiwari Amit K. 
Published: January 2020

:Flavonoids are low molecular weight, polyphenolic phytochemicals, obtained from secondary metabolism of various plant compounds. They have a spectrum of pharmacological efficacies, including potential anticancer efficacy. Natural flavonoids are present in fruits, vegetables, grains, bark, roots, stems, flowers, tea and wine. Flavonoids can attenuate or inhibit the initiation, promotion and progression of cancer by modulating various enzymes and receptors in diverse pathways that involve cellular proliferation, differentiation, apoptosis, inflammation, angiogenesis and metastasis. Furthermore, in vitro, flavonoids have been shown to reverse multidrug resistance when used as chemo-adjuvants. Flavonoids (both natural and synthetic analogues) interact with several oncogenic targets through dependent and independent mechanisms to mediate their anticancer efficacy in different types of cancer cells.
In-vitro Release Evaluation of Growth Hormone from an Injectable In-Situ Forming Gel Using PCL-PEG-PCL Thermosensitive Triblock
Authors: Khodaverdi Elham , Delroba Khadijeh , Mohammadpour Fatemeh , Khameneh Bahman , Sajadi Tabassi Sayyed A. , Tafaghodi Mohsen , Kamali Hossein , Hadizadeh Farzin 
Published: January 2020

Objective:
An injectable long acting In-Situ Forming Gel (ISFG) of human Growth Hormone
(hGH) was prepared by using triblock PCL-­‐PEG-­‐PCL
(Mw 1500-1500-1500). Ring-Opening Polymerization
(ROP) of triblock using microwave was applied.

Methods:
The BCA protein assay Kit was used to determine the concentration of hGH in the in-vitro
release medium. Finally, Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis (SDS-PAGE)
tests and Circular Dichroism (CD) spectrum were done to approve the stability of released hGH. The
result of ROP demonstrated that the proportion of PCL to PEG accorded with the initial molar ratio of
the monomers. The cross-section of the Surface Electron Microscopy (SEM) indicated the porous
framework of the hydrogel could load the drug into its tridimensional matrixes structure. There is the
low initial burst release of hGH from the supramolecular hydrogel.

Results:
The maximum in-vitro release of hGH was 71.2 % ± 1.5 that were due to hGH degrading after
this time (21 days). The CD spectrum and SDS-PAGE results confirmed the stability of hGH during invitro
release evaluation.

Conclusion:
The results suggest that the sustained-release formulation using PCL-PEG-PCL can be
applied to control the release of hGH.
Collocating Novel Targets for Tuberculosis (TB) Drug Discovery
Authors: Gandhi Karan , Patel Mehul 
Published: January 2020

Background:Mycobacterium tuberculosis, being a resistive species is an incessant threat to the world population for the treatment of Tuberculosis (TB). An advanced genetic or a molecular level approach is mandatory for both diagnosis and therapy as the prevalence of multi drug-resistant (MDR) and extensively drug- resistant (XDR) TB.Methods:A literature review was conducted, focusing essentially on the development of biomarkers and targets to extrapolate the Tuberculosis Drug Discovery process.Results and Discussion:In this article, we have discussed several substantial targets and genetic mutations occurring in a diseased or treatment condition of TB patients. It includes expressions in Bhlhe40, natural resistance associated macrophage protein 1 (NRAMP1) and vitamin D receptor (VDR) with its mechanistic actions that have made a significant impact on TB. Moreover, recently identified compounds; imidazopyridine amine derivative (Q203), biphenyl amide derivative (DG70), azetidine, thioquinazole, tetrahydroindazole and 2- mercapto- quinazoline scaffolds for several targets such as adenosine triphosphate (ATP), amino acid and fatty acid have been briefed for their confirmed hits and therapeutic activity.
Best Practices of Social Media for the Clinician
Authors: Alasnag Mirvat , Ahmed Waqar , Mamas Mamas 
Published: January 2020

:
Over recent years, social media use has substantially expanded not only for millennials,
but across all generations. Today, it no longer remains a means for simple social networking. It has
evolved into a powerful tool that can be used for career development, continued professional development
and global scientific engagement. Medical professionals, have employed social media platforms
to search for job opportunities, advertise meetings, participate in case discussions and network
with the medical community at large.

:

However, some caveats limit its widespread application amongst the clinical community.
The purpose of this review is to discuss the utility of social media, its drawbacks and best practices
for the clinicians.
Fast and Effective Confiscation of Methylene Blue Dye from Aqueous Medium by Luffa aegyptiaca Peel
Authors: Mashkoor Fouzia , Khan Mohd A. , Nasar Abu 
Published: January 2020

Background:
Dye contamination of natural water system is a severe problem due to the
considerable enhancement in the industrial activities. As the dyes are highly visible, nonbiodegradable,
and toxic in nature, they are considered as a severe source of water pollution. Therefore,
it is imperative to develop an inexpensive, simple, effective, and easy technique for their elimination
from wastewater.

Methods:
Luffa aegyptiaca peel (LuAP), kitchen waste was exploited as a low-priced biosorbent for
the adsorptive elimination of cationic methylene blue (MB) dye. The influence of several batch parameters,
i.e., adsorbent dose, pH of the solution, initial dye concentration, adsorbate/adsorbent contact
time, and temperature were optimized for maximum adsorption of MB from aqueous media. Furthermore,
thermodynamics, kinetics, and isotherm studies were also carried out in order to comprehend
the dominant mechanism for the adsorptive elimination of MB.

Results:
The kinetic data for the adsorption of MB onto the LuAP followed closely by the pseudosecond-
order (PSO) kinetics, and the adsorption equilibrium data were observed to be well demonstrated
by Langmuir isotherm. The equilibrium was attained in 180 min with maximum sorption capacity
of 52.63 mg/g at an adsorbent dose of 3 g/L, pH of 7, and temperature of 303 K. Thermodynamic
study reveals that the removal of MB by LuAP is spontaneous and endothermic.

Conclusion:
It has been concluded that LuAP can be efficiently utilized for the confiscation of cationic
MB dye from polluted water.
Identification, Isolation and Characterization of a Pharmaceutical Impurity in Levocetirizine Hydrochloride
Authors: Pei Shuchen , Chen Junlin , Xia Shihao , Wang Jieyu , Xue Buyin , Wang Qunliang , Chen Jun 
Published: January 2020

Background:
Levocetirizine is chemically know as (R)-(-)-2-[4-(4-chlorobenzhydryl)-1-
piperazinyl]-ethoxy acetic acid dihydrochloride. Many publications have reported the synthetic routes
of levocetirizine. Several related substances have been detected in levocetirizine hydrochloride drug
substances. In our study, a pharmaceutical impurity, at the level of >0.1% w/w, was isolated, purified
and identified. It is not included in the European Pharmacopoeia (EP).

Objective:
Identification, isolation and characterization of a new pharmaceutical impurity in levocetirizine
hydrochloride.

Methods:
The impurity was enriched by normal phase silica gel, and was further purified by semipreparative
HPLC. It was separated from the crystallization mother liquor of levocetirizine hydrochloride
for the first time. Mass spectrometry and nuclear magnetic resonance spectroscopy are the ultimate
tools in structure elucidation.

Results:
The structure was identified as levocetirizine quaternary ammonium. The formation mechanisms
of the impurity are also presented. The method was applied to the determination of the impurity
in levocetirizine hydrochloride in real samples.

Conclusion:
The method was applied to the determination the impurity of levocetirizine hydrochloride
in real samples.
Treatment of Psoriasis: A Comprehensive Review of Entire Therapies
Authors: Bakshi Harman , Nagpal Manju , Singh Manjinder , Dhingra Gitika Arora , Aggarwal Geeta 
Published: January 2020

Background:Psoriasis is an autoimmune disease that ingeminates itself with the repeated proliferation of keratinocytes. It globally strikes a 2-5 % population on an average. Management of psoriasis remains a daunting task with various challenges influencing treatment, such as patient conformity and adherence to therapy, delicate patient profiles, psychological aspects, and skin as a barrier to topical delivery. The first part reviewed pathophysiology, triggering factors, and clinical classification. The second part reviewed all the therapies, such as topical, oral, biological, parenteral therapy, phototherapy, and the phyto-pharmaceuticals.Methods:The research data related to the existing and upcoming therapies for psoriasis treatment, several nanocarriers, existing marketed formulations, and detailed description of phytopharmaceuticals with their mechanism.Results:Topical therapy is the mainstay treatment option with limited adverse effects. Biological therapy has reformed conventional psoriasis treatment by being more efficacious and has increased patient acceptance due to decreased adverse events. Nanoformulations present an edge over conventional therapy due to improved anti-psoriatic effect and decreased side effects. Phyto-pharmaceuticals act as a complementary and alternative therapy for diminishing psoriasis symptoms.Conclusion:A rationalized cost-effective patient compliant therapy is required for effective management and complete cure of psoriasis.
Effect of Mechanical Activation on Leachability of Fayalite in Sulfuric Acid Solution
Authors: Nadirov Rashid , Mussapyrova Lyazzat 
Published: January 2020

Background:
Being by-products of non-ferrous metallurgy, slags contain fayalite
(Fe2SiO4) as the major component. Since hydrometallurgical methods are considered as
the most promising for processing such material to obtain valuable metals, increasing the
leachability of fayalite in sulfuric acid as a widely used leaching agent is an important task.

Objective :
The present work was devoted to increasing the reactivity of fayalite by using
mechanical activation.

Methods:
Fayalite, synthesized with the use of powders of metallic Fe, Fe2O3, and SiO2,
was subjected to mechanical activation in the planetary ball mill at 400 rpm with a
ball/powder ratio of 5 for 45 minutes. Then, activated and non-activated fayalite samples
were subjected to sulfuric acid leaching. Before leaching, solid samples were characterized
by XRD and Dynamic Light Scattering (DLS). Quantitative analysis of Fe and Si in the
leachate was determined by Inductively Coupled Plasma-Atomic Emission Spectroscopy.

Results:
Mechanical activation led to partial amorphization of the initial fayalite sample. It
was found that the leaching rate constants of the treated samples in sulfuric acid solution
(50-80 g×L-1) at 298, 338, and 368 K increased and the activation energy of the leaching
process decreased, i.e. mechanical activation enhances the reactivity of fayalite in H2SO4
solution.

Conclusion:
Mechanical activation can be applied to improve fayalite leachability in sulfuric
acid solution. The results obtained can be used in the development of methods for
leaching slag of non-ferrous metallurgy, in particular, copper smelter slags, the major
component of which is fayalite.
Polymer Anchored Gold Nanoparticles: Synthesis, Characterization and Antimicrobial Activities
Authors: Chowdhury Pranesh , Roy Bishnupada , Mukherjee Suprabhat , Mukherjee Niladri , Joardar Nikhilesh , Roy Debiprasad , Chowdhury Shreyashi , Babu Santi P.S. 
Published: January 2020

Background::
Gold nanoparticles (GNPs) have diverse optical and photo-thermal properties.
It is used for diagnostic imaging because of their ability to absorb near infrared (NIR) and
X-rays, and their surface enhanced Raman scattering properties. Recently they are used for drug
delivery and more particularly photothermal treatment. Their ability to absorb NIR energy and
convert it to heat by a Surface Plasmon Resonance mechanism has made these materials promising
for the treatment of tumors. GNPs having diameter higher than 1.4-1.5 nm is found nontoxic to the
environment.

Methods::
In the present work, polymer anchored GNPs are synthesized by reducing AuIII to Au0
in presence of either chitosan or polyvinyl alcohol, which act as in situ reducers cum stabilizers.
Microscopic techniques (TEM, SEM and DLS) are used to analyse the size, surface morphology
and size distribution respectively. The unique mucoadhesive properties of chitosan particularly
make the system promising with respect to antimicrobial (anti-bacteria as well as anti-fungus) activities.
An attempt has been made to understand the mechanistic path involved in antimicrobial
activities. Antimicrobial potential of chitosan anchored gold nanoparticles (GNPc) are noticed
even at very low dose.

Results::
The results of bio-chemical analysis (MDA, NBT, DNA fragmentation and overexpression
of heat shock protein) clearly explain antimicrobial activities. Additionally, gold chitosan
systems interact with microbial DNA and inhibit the action of DNA repair enzyme. Interestingly,
in vitro (rat peritoneal MФ) or in vivo (Wistar rat) analysis exhibits negligible cytotoxicy.

Conclusion::
Thus the synthesized material (particularly GNPc) is promising as an effective nano
therapeutic agent.
Coexistence of Metallo Beta Lactamase Resistant Gene Variants Among Clinical Isolates in Tertiary Care Hospital
Authors: K. Santhiya , S. Jayanthi , M. Ananthasubramanian , B. Appalaraju 
Published: January 2020

Background:Carbapenem-resistant Enterobacteriaceae (CRE) has emerged as a global threat with mortality risk ranging from 48%-71% worldwide. The emergence of MBL resistance is threatening as carbapenem is one of the last line antibiotics. A total 24 variants of NDM resistance raises a concern to the clinicians and epidemiologists worldwide.Objective:The study aims at identifying MBL resistance (NDM, IMP, VIM, GIM, SPM, and SIM) and its coexistence in clinical isolates in a single tertiary care center.Methodology:Forty five clinical isolates characterized phenotypically for Carbapenem resistance obtained from PSG Institute of Medical Science and Research (PSG IMSR), Coimbatore, between February to March 2018 were taken for analysis.Result:Out of the 45 Clinical isolates, 38 isolates (84%) were detected as MBL carriers. VIM, NDM, GIM, and SPM were the predominant resistance genes, with detection rates of 48.8%, 28.8%, 24.4%, and 22.2% respectively. Fifteen isolates were observed to harbor more than one MBL gene in coexistence. Two isolates - U42 and R714 (K. pneumoniae) were found to harbor all 5 MBL variants in combination.Conclusion:33% of clinical isolates harboring multiple MBL variants is a concern in clinical settings. The presence of SPM and GIM gene amongst isolates in this geographical location within India is an indicator demanding continuous monitoring of these resistance determinants.
Cyberphysical Human Sexual Behavior Acquisition System (SeBA): Development and Implementation Study in China
Authors: Zhou Xiaoping , Zhao Jichao , Liang Xun 
Published: January 2020

Background
Sexual health is one of the principal components of human well-being. Traditional methods for observing human sexual behavior typically adopt manual intervention approaches (eg, interviews). However, the data obtained by such traditional approaches suffer from intrinsic bias and limited sample sizes.

Objective
To address the limitations of traditional human sexual behavior data observation methods, a novel cyberphysical system is proposed to capture natural human sexual behavior data in China at the nationwide level.

Methods
A cyberphysical human sexual behavior acquisition system (SeBA) was designed and implemented. SeBA jointly utilizes state of the art information and communication technologies such as smart sex toys, smartphones, and mobile social networks. Smart sex toys enable objective collection of data on human sexual behavior, while the mobile social network provides the possibility of partnered sex in a cyberphysical manner. The objectives and function settings are discussed, and the overall framework of the system architecture is presented.

Results
Operation and privacy policies are proposed and the technical solution of SeBA is described. The effectiveness of SeBA was verified based on analysis of users’ human sexual behavior data collected from January 2016 to June 2017. A total of 103,424 solo sexual behaviors were recorded involving 13,047 users, and 61,007 partnered sexual behaviors from 7,140 users were observed. The proportions of males and females in the solo and partnered sex groups were fairly consistent with recent statistics on unmarried individuals in China. We also found that only a small portion of individuals provided information on at least one other attribute besides the required input of gender, such as age, height, location, job, sex preferences, purposes, and interests.

Conclusions
To the best of our knowledge, this is the first study to analyze objective human sexual behavior data at the nationwide level. Although the data are restricted to China, this study can provide insight for further research on human sexual behavior based on the huge amount of data available from wireless smart sex toys worldwide. It is anticipated that findings from such objective big data analyses can help deepen our understanding of sexual behavior, as well as improve sexual health and sexual wellness.