bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measles in children. Weren’t you waiting? What should a pediatrician know
Authors: Zakharova I. N. , Osmanov I. M. , Berezhnaya I. V. , Maykova I. D. , Dubovets N. F. , Aysanova M. R. , Trukhina A. V. 
Published: July 2020

From a long time ago to the present day, measles remains one of the leading health problems in the world. The main reason for this is high mortality from measles – 1/500. Despite the availability of an effective and safe vaccine, which was discovered in 1963, there are still epidemic outbreaks of measles. According to WHO, there were 413,308 confirmed cases in 187 countries and 764 deaths during 2019. Most measles deaths are due to complications associated with the disease.Complications are most common in children under five or in adults over 30 years of age. The most serious complications include blindness, encephalitis leading to cerebral edema, severe diarrhoea and associated dehydration, purulent otitis and severe lower respiratory tract infections such as pneumonia. In a study from 2019, Michael J. Mina and colleagues showed that after measles in the group of unprivileged people, 11 to 73% of previous immune memory is “erased”. Currently, there is no specific etiotropic therapy for measles. One of the pathogenetic links in therapy is the use of interferon replacement therapy. According to the Federal Clinical Recommendations and WHO recommendations, the use of recombinant interferon α-2B and vitamin A is recommended. The effectiveness of interferonotherapy for measles was first shown in 1992 by the Leopardi R team. This study showed that the secretion of measles virus in human peripheral blood mononuclear cells was gradually reduced by increasing the concentrations and blocked at the concentration of interferon α-2B in 1000 units/ml. Moreover, at the XXIV World Congress of Neuroscientists (WCN) it was noted that the safest and most effective method of treatment of subacute sclerosing panencephalitis, one of the severe complications of measles, is recombinant human α-2B interferon.
Study of EGFR expression in tumor tissue in patients with locally advanced oral cavity cancer receiving cetuximab therapy
Authors: Lyanova A. A. , Vladimirova L. Yu. , Ulianova E. P. , Storozhakova A. E. , Abramova N. A. , Popova I. L. , Teplyakova M. A. , Tikhanovskaya N. M. , Myagkova V. S. , Novoselova K. A. , Ryadinskaya L. A. , Strakhova L. K. , Kalabanova E. A. 
Published: July 2020

Introduction:Squamous cell carcinoma of the oral cavity is one of the most common head and neck cancers with an aggressive course and high mortality rates.The aimof the study was to determine the EGFR expression levels in tumor tissues in patients with squamous cell carcinoma of the tongue and oral mucosa depending on the efficacy of the therapy.Material and methods:The study included 60 patients with squamous cell carcinoma of the tongue and oral mucosa T3-4N0-1M0. The main group included 30 patients receiving chemotherapy (cisplatin/fluorouracil) in combination with targeted therapy with cetuximab. The control group included 30 patients receiving chemotherapy without cetuximab. Both groups were divided into two subgroups: sensitive and resistant.Results:In treatment-resistant patients of the main group with cetuximab, the average EGFR expression was twice lower than the initial levels (p = 0.0080) and 1.7 times higher than in treatment-resistant patients of the control group (p = 0.0157). In treatment-sensitive patients, the average EGFR expression was 19.8 times lower (p = 0.0020) than initial values and 14.9 times higher (p = 0.0067) than in treatment-sensitive controls.Conclusions:A natural decrease in the EGFR expression in tumor tissues due to the targeted therapy was revealed. However, some patients were resistant to cetuximab, which dictates the need to search for predictors of targeted therapy efficacy in patients with locally advanced squamous cell carcinoma of the tongue and oral mucosa.
A EXPERIÊNCIA COMO PRÁTICA FORMATIVA DE ESTUDANTES ATRAVÉS DA EXTENSÃO UNIVERSITÁRIA
Authors: Cunha Ana Luiza Salgado , Barletto Marisa , Costa Glauber Barros Alves 
Published: July 2020

Este trabalho teve como tema a experiência enquanto prática formativa de estudantes envolvidos em atividades de Extensão Universitária. O principal objetivo foi qualificar a dimensão da experiência construída por estudantes universitários, compreendendo como estas incidem em suas trajetórias e como as tratam na sua formação acadêmica. Apresentamos os resultados de um dos quatro grupos focais realizados e a metodologia utilizada enquanto instrumento de produção de informações sobre as experiências extensionistas, com destaque aos discursos construídos coletivamente pelos estudantes. Os resultados permitiram-nos qualificar as experiências dos universitários na perspectiva da historicidade das práticas de Extensão, compreendendo a existência de outras formas de tecer conhecimentos, nos quais a Extensão Universitária aparece como uma das possibilidades de abertura de espaços para o que anunciam os novos paradigmas.
Extended Spectrum Beta Lactamase (ESBL), blaTEM,blaSHV and blaCTX-M, Resistance Genes in Community and Healthcare Associated Gram Negative Bacteria from Osun State, Nigeria
Authors: Shitta Ganiyat , Makanjuola Olufunmilola , Adefioye Olusolabomi , Olowe Olugbenga Adekunle 
Published: July 2020

Background:
Extended Spectrum Beta Lactamase (ESBL) production in gram negative
bacteria confers multiple antibiotic resistance, adversely affecting antimicrobial therapy in infected
individuals. ESBLs result from mutations in β-lactamases encoded mainly by the blaTEM,blaSHV and
blaCTX-M genes. The prevalence of ESBL producing bacteria has been on the increase globally, especially
its upsurge among isolates from community-acquired infections has been observed.

Aim:
To determine ESBL prevalence and identify ESBL genes among clinical isolates in Osun
State, Nigeria.

Material and Methods:
A cross-sectional study was carried out from August 2016 – July 2017 in
Osun State, Nigeria. Three hundred and sixty Gram-negative bacteria recovered from clinical samples
obtained from both community and healthcare-associated infections were tested. They included
147 Escherichia coli (40.8%), 116 Klebsiella spp (32.2%), 44 Pseudomonas aeruginosa
(12.2%) and 23 Proteus vulgaris (6.4%) isolates. Others were Acinetobacter baumannii, Serratia
rubidae, Citrobacter spp, Enterobacter spp and Salmonella typhi. Disk diffusion antibiotic susceptibility
testing was carried out, isolates were screened for ESBL production and confirmed using
standard laboratory procedures. ESBLs resistance genes were identified by Polymerase Chain
Reaction (PCR).

Results:
All isolates demonstrated multiple antibiotic resistance. Resistance to ampicillin, amoxicillin
with clavulanate and erythromycin was 100%, whereas resistance to Imipenem was very low
(5.0%).

:
The overall prevalence of ESBL producers was 41.4% with Klebsiella spp as the highest ESBL producing
Enterobacteriacaea. ESBL producers were more prevalent among the hospital pathogens
than community pathogens, 58% vs. 29.5% (p=0.003). ESBL genes were detected in all ESBL producers
with the blaCTX-M gene predominating (47.0%) followed by blaTEM (30.9%) and blaSHV gene
was the least, 22.1%. The blaCTX-M gene was also the most prevalent in the healthcare pathogens
(62%) but it accounted for only 25% in those of community origin.

Conclusion:
A high prevalence of ESBL producing gram-negative organisms occurs both in healthcare
and in the community in our environment with the CTX-M variant predominating. Efforts to
control the spread of these pathogens should be addressed.
Evaluation of Biological Activity of Derivatives of 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and 1,2,4-Triazole
Authors: Doshi Gaurav M. , Bansode Mayuresh U. , Somani Rakesh R. 
Published: July 2020

Objectives:
1,3,4-thiadiazole (A), 1,3,4-oxadiazole (B) and 1,2,4-triazole (C) derivatives
have been known for their immense pharmacotherapeutic potential. The current research article attempts
to further explore and understand the probable biochemical mechanism related to antiinflammatory
activity of derivatives.

Methods:
The screened A, B and C derivatives were investigated for both in-vitro (Erythrocyte Membrane
stabilization activity, Proteinase enzyme inhibitory activities) and in-vivo correlation using acute
and chronic anti-inflammatory potential by carrageenan induced rats paw edema and cotton pellet
granuloma methods, respectively. The activity was studied after interpreting acute toxicity studies results.

Results:
In vitro studies in the case of Erythrocyte Membrane stability and Proteinase enzyme inhibitory
activities exhibited by A, B, and C at 100 ppm were found to be 48.89%, 51.08% and 50.08% and
66.78%, 76.91% and 57.41%, respectively. The maximum toxic dose was found to be 2000 mg/kg.
The derivatives were studied for two-dose levels viz; Lower (100 mg/kg) and higher dose (200 mg/kg).
In rat paw edema, maximum decrease was obtained for A (50.05%), B (50.05%) and C (51.06%) at
lower and higher dose at 68.76%, 55.61%, and 65.26%, respectively for effect up to 24 h. In the
chronic model of cotton pellet granuloma viz; higher and lower doses of A, B and C exhibited 38.15%,
33.19% and 30.25 % and 19.45%, 18.55% and 17.55 %, respectively.

Conclusion:
The studied models depicted that derivatives A, B and C have the probable potential as
anti-inflammatory agents. Further studies need to be undertaken to explore their potential in the different
therapeutic areas.
PENGARUH PEMBERITAAN BENCANA 28 SEPTEMBER 2018 DI KOMPAS TV TERHADAP TINGKAT KECEMASAN KERABAT KORBAN DI KOTA MAKASSAR
Authors: Sukmawati Anwar  , Mahpuddin  
Published: July 2020

Gempa bumi yang melanda Kota Palu dan sekitarnya pada tanggal 28 september 2018, mengguncang dengan kekuatan 7,4 SR pada pukul 17.02 WIB. Gempa bumi juga disertai gelombang tsunami yang menerjang Pantai Talise di Kota Palu dan Pantai Donggala, total korban jiwa mencapai kurang lebih 2.113 orang. Televisi sebagai media informasi yang merekam kejadian tersebut, memiliki kekuatan yang ampuh untuk menyampaikan pesan secara cepat, sehingga informasi dapat segera tersampaikan pada keluarga, teman atau kerabat korban yang berada di sekitar Kota Palu maupun yang jauh dari lokasi kejadian, yang kemudian menghasilkan berbagai emosi bagi kerabat korban, salah satu efek yang muncul adalah kecemasan.Dengan menggunkana teori Jarum Hipodermik sebagai alat ukur penelitian ini berusaha untuk menemukan hubungan terpaan media terhadap kecemasan pada kerabat korban gempa dan likuifaksi di Kota Palu-Donggala., melalui metode kuantitatif yang menggunakan responden sebanyak 45 orang yang masing-masing merupakan kerabat korban yang berdomisili di Kota Makassar. Dengan melakukan analisis regresi linear sederhana maka ditemukan bahwa terpaan media berpengaruh terhadap kecemasan sebesar 0.687 (p=0.00; F=94.58), dan dapat dikatakan bahwa terpaan media televisi memberikan kontribusi terhadap kecemasan kerabat korban sebesar 68.7% atau hubungan yang kuat.
Pengaruh Tata Kelola Perusahaan, Reputasi KAP, Karakteristik Perusahaan dan Opini Audit terhadap Audit Delay
Authors: David M Hilda Azalia , Butar Sansaloni Butar 
Published: July 2020

Abstract
Financial statements may help investors in estimating firm’s future performance. The sooner they are published, the more relevant the information for making investment decision. A delay in the release of financial statements may result from audit delay. Audit delay is a period of time the process of auditing measured from the date book company up to date stated in a report auditor independent. This study examines the factors that can influence the audit delay period for public companies on Indonesia Stock Exchange in 2014 to 2018. The independent variables used in this study are the existence of the governance committee, the size of the audit committee, the reputation of the firm (KAP), the company's complexity, profits and audit opinion. Employing purposive sampling method, this study collect final sample of 1866 companies which used to test the hypotheses. Using logistic regression. the evidents show that the existence of the governance committee, KAP reputation, and profit were negatively associated with audit delay. Meanwhile, firm complexity was positively associated with audit delay. In addition, the size of the audit committee has no effect on audit delay.
Keywords: audit delay, corporate governance, KAP reputation, company complexity, audit opinion.

Abstrak
Laporan keuangan membantu investor mengestimasi kinerja perusahaan di masa depan. Semakin cepat laporan keuangan dipublikasikan maka semakin relevan digunakan dalam pengambilan keputusan investasi. Keterlambatan pelaporan keuangan bisa dipucu oleh audit delay. Audit delay adalah jangka waktu penyelesaian proses audit yang diukur dari tanggal tutup buku perusahaan hingga tanggal yang tertera pada laporan auditor independen. Penelitian ini menguji kembali faktor-faktor yang dapat mempengaruhi masa audit delay pada perusahaan publik yang terdapat di BEI tahun 2014 hingga 2018. Variabel independen yang digunakan dalam penelitian ini adalah keberadaan komite tata kelola, ukuran komite audit, reputasi KAP, kompleksitas perusahaan, laba dan opini audit. Penentuan sampel menggunakan metode purposive sampling dengan jumlah sampel akhir yang digunakan yaitu 1866 perusahaan. Analisis menggunakan regresi logistik. Hasil pengujian menunjukkan bahwa keberadaan komite tata kelola, reputasi KAP, dan laba berpengaruh negatif terhadap audit delay, dan kompleksitas perusahaan berpengaruh positif terhadap audit delay, sedangkan ukuran komite audit tidak berpengaruh terhadap audit delay.
Kata kunci: audit delay, tata kelola perusahaan, reputasi KAP, kompleksitas perusahaan, opini audit.
Pengaruh Kepemilikan Institusional, Ukuran Komite Audit, Kualitas Audit, Dan Komite Remunerasi Terhadap Pengungkapan Kompensasi Manajemen Kunci
Authors: Yulianata Erlinda 
Published: July 2020

Abstract
This study examine the effect of institutional ownership, audit committee size, audit quality, and remuneration committee on disclosure of key management compensation. The population used in this study is the financial statements of all companies listed on the Indonesia Stock Exchange (IDX) for the period 2013-2017. The type of data used in this study is secondary data. The data analysis technique in this study is the logistic regression analyst. The results of this study show that audit committee size, audit quality, and remuneration committee have positive effects on disclosure of key management compensation. On the contrary, institutional ownership has no effect on the disclosure of key management compensation in the financial statements,
Keywords: institutional ownership, audit committee size, audit quality, remuneration committee, disclosure of key management compensation

Abstrak
Penelitian ini bertujuan untuk mengetahui pengaruh kepemilikan institusional, ukuran komite audit, kualitas audit, dan komite remunerasi terhadap pengungkapan kompensasi manajemen kunci. Populasi yang digunakan dalam penelitian ini adalah laporan keuangan dari semua perusahaan yang terdaftar di Bursa Efek Indonesia (BEI) periode tahun 2013-2017. Jenis data yang digunakan dalam penelitian ini adalah data sekunder. Teknik analisis data pada penelitian ini adalah analis regresi logistik. Hasil penelitian menunjukkan kepemilikan institusional tidak berpengaruh terhadap pengungkapan kompensasi manajemen kunci di laporan keuangan, ukuran komite audit berpengaruh positif terhadap pengungkapan kompensasi manajemen kunci di laporan keuangan, kualitas audit berpengaruh positif terhadap pengungkapan kompensasi manajemen kunci di laporan keuangan, dan komite remunerasi berpengaruh positif terhadap pengungkapan kompensasi manajemen kunci di laporan keuangan.
Kata kunci: kepemilikan institusional, ukuran komite audit, kualitas audit, komite remunerasi, pengungkapan kompensasi manajemen kunci
Analisis Pengaruh Kinerja Keuangan dan Tata Kelola Perusahaan Terhadap Kondisi Kesehatan Keuangan Perusahaan
Authors: Sanny Sanny , Warastuti Yusni 
Published: July 2020

Abstract
Company’s financial health is one of the important factors that must be maintained by the company to maintain the sustainability of its business. The objective of the study is to examine the effect of financial performance and corporate governance on financial health. Financial performance is reflected by three indeps: leverage, liquidity, and profitability. While corporate governance is reflected by managerial ownership, institutional ownership, the proportion of independent commissioners, and the size of audit committee. This study used financial report of listed manufacturing companies in Indonesia Stock Exchange (IDX) during 2013-2017. The data was collected by purposive sampling. This study used logistic regression analysis to examine seven of independent variables on financial health. The result indicate leverage and institutional ownership were significant and negatively affected the company’s financial health. While liquidity and profitability were significant and positively affected the company’s financial health.
Keywords: financial health, financial distress, financial performance, corporate governance.

Abstrak
Kesehatan keuangan perusahaan merupakan salah satu faktor penting yang harus dijaga oleh perusahaan untuk mempertahankan keberlanjutan usahanya. Tujuan dari penelitian ini adalah untuk menganalisis pengaruh dari kinerja keuangan dan tata kelola perusahaan terhadap kondisi kesehatan perusahaan. Kinerja keuangan di cerminkan oleh tiga variabel: leverage, likuiditas, dan profitabilitas. Sedangkan tata kelola perusahaan dicerminkan oleh kepemilikan manajerial, kepemilikan institusional, proporsi dewan komisaris independen, dan ukuran komite audit. Penelitian ini menggunakan laporan keuangan perusahaan manufaktur yang terdaftar di BEI tahun 2013-2017. Data dikumpulkan menggunakan metode purposive sampling. Penelitian ini menggunakan analisis regresi logistik dan hasil penelitian menemukan bahwa leverage dan kepemilikan institusional berpengaruh secara signifikan dan negatif terhadap kondisi kesehatan keuangan perusahaan yang berarti perusahaan dengan leverage dan kepemilikan institusional tinggi cenderung berada pada kondisi financial distress, sedangkan likuiditas dan profitabilitas berpengaruh signifikan dan positif terhadap kondisi kesehatan keuangan perusahaan yang berarti bahwa perusahaan dengan likuiditas dan profitabilitas tinggi akan cenderung pada kondisi finansial sehat.
Kata Kunci: Kondisi kesehatan keuangan, kesulitan keuangan, kinerja keuangan, tata kelola perusahaan.
Caring Climate, Komitmen Organisasi, Dan Kepuasan Kerja
Authors: Priliyanto Yunus Ardian , Murniati Monika Palupi 
Published: July 2020

Abstract
This study aims to analyze the effect of caring climate on employee performance by mediating variable job satisfaction and organizational commitment according to gender proportions. Caring climate is a way for people to make decisions that prioritize the welfare of all people. The sample of this study was 96 employees of Soegijapranata Catholic University Semarang. Fit test is conducted to find out whether the research model meets the structural equation model assumptions or not, the data is said to be fit after deleting 10 data, so that the remaining 86 sample data. This study uses SEM (Structural Equation Modeling) with the AMOS program. The results of this study are that Caring climate influences organizational commitment through the mediating role of job satisfaction, Caring climate influences employee performance through the mediating role of job satisfaction, but Caring climate does not affect employee performance through the mediating role of organizational commitment, Job satisfaction does not affect employee performance through the mediating role of organizational commitment, and Gender becomes a differentiator in the perception of male and female respondents towards caring climate, employee performance, job satisfaction and organizational commitment.
Keywords: caring climate, job satisfaction, organizational commitment, job performance, gender

Abstrak
Penelitian ini bertujuan untuk menganalisis pengaruh caring climate terhadap kinerja karyawan dengan mediasi variabel kepuasan kerja dan komitmen organisasi menurut proporsi gender. Caring climate merupakan cara orang dalam mengambil keputusan yang mengutamakan kesejahteraan semua orang. Sampel penelitian ini adalah 96 karyawan Universitas Katolik Soegijapranata Semarang. Uji fit dilakukan pertama untuk mengetahui model penelitian memenuhi asumsi model persamaan struktural atau tidak, data dikatakan fit setelah menghapus 10 data, sehingga tersisa 86 data sampel. Penelitian ini menggunakan SEM (Structural Equation Modelling) dengan program AMOS. Hasil penelitian ini adalah Caring climate berpengaruh terhadap komitmen organisasi melalui peran mediasi kepuasan kerja, Caring climate berpengaruh terhadap kinerja karyawan melalui peran mediasi kepuasan kerja, tetapi Caring climate tidak berpengaruh terhadap kinerja karyawan melalui peran mediasi komitmen organisasi, Kepuasan kerja tidak berpengaruh terhadap kinerja karyawan melalui peran mediasi komitmen organisasi, dan Gender menjadi pembeda persepsi responden laki-laki dan perempuan terhadap caring climate, kinerja karyawan, kepuasan kerja dan komitmen organisasi.
Kata kunci: caring climate, kepuasan kerja, komitmen organisasi, kinerja karyawan, Gender.
Pengaruh Risiko Keuangan, Dividen, Kepemilikan Manajerial dan Reputasi Auditor Terhadap Perataan Laba
Authors: Karina Sinta Nadya 
Published: July 2020

Abstract
This study reexamine the effect of financial risk, dividen, managerial ownership, auditor reputation on income smoothing practice by taking firm samples from Indonesia Stock Exchange. Eckel Index is used as a measure of income smoothing. Firms samples were drawn from companies listed on Indonesia Stock Exchange in the period of 2011-2015. Using logistic regression, the evidence showed that financial risk has an effect on income smoothing. On the contrary, dividen, managerial ownership, and auditor reputation have no significant effect on the income smoothing. Several control variables were also tested and the results show that leverage and profitability have significant effect on income smoothing.
Keywords: Finance Risk, Dividen, Managerial Ownership, Auditor Reputation, Income Smoothing.

Abstrak
Penelitian ini bertujuan untuk mengetahui pengaruh Risiko Keuangan, Dividen, Kepemilikan Manajerial dan Reputasi Auditor terhadap Perataan Laba yang menggunakan seluruh tipe perusahaan yang terdaftar di Bursa Efek Indonesia. Indeks Eckel digunakan untuk menentukan praktik perataan laba. Populasi dalam penelitian ini adalah semua perusahaan yang terdaftar di Bursa Efek Indonesia pada tahun 2011-2015. Hasil pengujian hipotesis menunjukkan bahwa risiko keuangan berpengaruhi signifikan terhadap perataan laba. Sementara, dividen, kepemilikan manajerial dan reputasi auditor tidak berpengaruh signifikan terhadap praktik perataan laba. Dalam penelitian ini juga ditambahkan variabel kontrol yaitu ukuran perusahaan, profitabilitas, dan tingkat utang. Hasil pengujikan menunjukkan hanya tingkat utang dan profitabilitas yang berpengaruh terhadap perataan laba.
Kata Kunci: Risiko Keuangan, Dividen, Kepemilikan Manajerial, Reputasi Auditor, Perataan Laba.