bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trajectory and early predictors of apathy development in first-episode psychosis and healthy controls: a 10-year follow-up study
Authors: Lyngstad Siv Hege , Gardsjord Erlend Strand , Engen Magnus Johan , Haatveit Beathe , Ihler Henrik Myhre , Wedervang-Resell Kirsten , Simonsen Carmen , Melle Ingrid , Færden Ann 
Published: March 2020

AbstractApathy is prevalent in first-episode psychosis (FEP) and associated with reduced global functioning. Investigations of the trajectory of apathy and its early predictors are needed to develop new treatment interventions. We here measured the levels of apathy over the first 10 years of treatment in FEP and in healthy controls (HC). We recruited 198 HC and 198 FEP participants. We measured apathy with the Apathy Evaluation Scale, self-report version, psychotic symptoms with the Positive and Negative Syndrome Scale, depression with the Calgary Depression Scale for Schizophrenia, functioning with the Global Assessment of Functioning Scale, and also estimated the duration of untreated psychosis (DUP). The longitudinal development of apathy and its predictors were explored using linear mixed models analyses. Associations to functioning at 10 years were investigated using multiple hierarchical linear regression analyses. In HC, mean apathy levels were low and stable. In FEP, apathy levels decreased significantly during the first year of treatment, followed by long-term stability. High individual levels of apathy at baseline were associated with higher apathy levels during the follow-up. Long DUP and high baseline levels of depression predicted higher apathy levels at follow-ups. The effect of DUP was persistent, while the effect of baseline depression decreased over time. At 10 years, apathy was statistically significantly associated with reduced functioning. The early phase of the disorder may be critical to the development of apathy in FEP.
Other primary headaches—thunderclap-, cough-, exertional-, and sexual headache
Authors: Bahra Anish 
Published: March 2020

AbstractThis article reviews the disorders of thunderclap, cough, exertional and sexual headache. These are a group of paroxysmal and precipitated headaches, which often occur in bouts with prolonged remissions. Indometacin seems to be the most effective preventative. Each can occur in primary and secondary form. Thunderclap headache is the most frequently reported headache syndrome associated with a secondary pathology. Discussed are the complexities of whether all patients with thunderclap headache should have further investigation if timely computerised tomography is normal and, the relevance of abnormal imaging in these disorders, differentiating what is deemed to be secondary and managing the pain.
Drooling in Parkinson’s Disease: Prevalence and Progression from the Non-motor International Longitudinal Study
Authors: van Wamelen Daniel J. , Leta Valentina , Johnson Julia , Ocampo Claudia Lazcano , Podlewska Aleksandra M. , Rukavina Katarina , Rizos Alexandra , Martinez-Martin Pablo , Chaudhuri K. Ray 
Published: March 2020

AbstractSialorrhoea in Parkinson’s disease (PD) is an often neglected yet key non-motor symptom with impact on patient quality of life. However, previous studies have shown a broad range of prevalence figures. To assess prevalence of drooling in PD and its relationship to quality of life, we performed a retrospective analysis of 728 consecutive PD patients who had a baseline and follow-up assessment as part of the Non-motor International Longitudinal Study (NILS), and for whom drooling presence and severity were available, assessed through the Non-Motor Symptoms Scale (NMSS). In addition, we analysed the prevalence of associated dysphagia through self-reported outcomes. Quality of life was assessed through the PDQ-8 scale. Baseline (disease duration 5.6 years) prevalence of drooling was 37.2% (score ≥ 1 NMSS question 19), and after 3.27 ± 1.74 years follow-up, this was 40.1% (p = 0.17). The prevalence of drooling increased with age (p < 0.001). The severity of drooling, however, did not change (p = 0.12). While in 456 patients without drooling at baseline, only 16% (n = 73) had dysphagia (question 20 of the NMSS), in those with drooling this was 34.3% (p < 0.001). At follow-up, the number of patients with dysphagia had increased, 20.4% with no drooling had dysphagia, and 43.6% with drooling had dysphagia. Both at baseline and follow-up, drooling severity was significantly positively associated with quality of life (PDQ-8; r = 0.199; p < 0.001). In moderately advanced PD patients, subjective drooling occurs in over one-third of patients and was significantly associated with decreased quality of life. Dysphagia occurred significantly more often in patients with drooling.
Trends in incidence of anal cancer in Austria, 1983–2016
Authors: Heer Emily , Hackl Monika , Ferlitsch Monika , Waldhoer Thomas , Yang Lin 
Published: March 2020

Summary
Background
Recent reports have noted increasing rates of anal cancer among high-income countries worldwide; however, little is known about these trends in Austria.

Methods
Data on anal cancer from 1983 to 2016 were obtained from Statistics Austria. All tumors (n = 3567) were classified into anal squamous cell carcinomas (ASCC), anal adenocarcinomas (AADC), and others (unspecified carcinoma and other specific carcinoma). Anal cancer incidence rates were calculated in 5‑year cycles and incidence average annual percentage change (AAPC) to evaluate trends by sex, histology and age group.

Results
The incidence rate of anal cancer was higher among females than males (relative risk, RR = 1.66, 95% confidence interval, CI: 1.55–1.79, p < 0.0001). From 1983 through 2016, incident anal cancer increased significantly (0.92 per 100,000 person-years to 1.85 per 100,000 person-years, AAPC = 1.93, 95% CI: 1.52 to 2.34, p < 0.0001), particularly among those 40–69 years old. From 1983 through 2016, the increasing anal cancer incidence was primarily driven by ASCC (0.47–1.20 per 100,000 person-years, AAPC = 2.23, 95% CI: 1.58 to 2.88, p < 0.0001) and others (other than ASCC and AADC, AAPC = 1.78, 95% CI: 1.01–2.55), yet stable in AADC (AAPC = 0.88, 95% CI: −0.48–2.25).

Conclusions
Despite being a rare cancer in Austria, the increase in anal cancer incidence rate from 1983 to 2016 was substantial, particularly in ASCC. The observed rising trends reflect the need to investigate associated risk factors that have increased over time to inform preventive measures.
Semi-invariant Riemannian metrics in hydrodynamics
Authors: Bauer Martin , Modin Klas 
Published: March 2020

AbstractMany models in mathematical physics are given as non-linear partial differential equation of hydrodynamic type; the incompressible Euler, KdV, and Camassa–Holm equations are well-studied examples. A beautiful approach to well-posedness is to go from the Eulerian to a Lagrangian description. Geometrically it corresponds to a geodesic initial value problem on the infinite-dimensional group of diffeomorphisms with a right invariant Riemannian metric. By establishing regularity properties of the Riemannian spray one can then obtain local, and sometimes global, existence and uniqueness results. There are, however, many hydrodynamic-type equations, notably shallow water models and compressible Euler equations, where the underlying infinite-dimensional Riemannian structure is not fully right invariant, but still semi-invariant with respect to the subgroup of volume preserving diffeomorphisms. Here we study such metrics. For semi-invariant metrics of Sobolev $$H^k$$Hk-type we give local and some global well-posedness results for the geodesic initial value problem. We also give results in the presence of a potential functional (corresponding to the fluid’s internal energy). Our study reveals many pitfalls in going from fully right invariant to semi-invariant Sobolev metrics; the regularity requirements, for example, are higher. Nevertheless the key results, such as no loss or gain in regularity along geodesics, can be adopted.
Improved quality assessment of colour surfaces for additive manufacturing based on image entropy
Authors: Okarma Krzysztof , Fastowicz Jarosław 
Published: March 2020

AbstractA reliable automatic visual quality assessment of 3D-printed surfaces is one of the key issues related to computer and machine vision in the Industry 4.0 era. The colour-independent method based on image entropy proposed in the paper makes it possible to detect and identify some typical problems visible on the surfaces of objects obtained by additive manufacturing. Depending on the quality factor, some of such 3D printing failures may be corrected during the printing process or the operation can be aborted to save time and filament. Since the surface quality of 3D-printed objects may be related to some mechanical or physical properties of obtained objects, its fast and reliable evaluation may also be helpful during the quality monitoring procedures. The method presented in the paper utilizes the assumption of the increase of image entropy for irregularly distorted 3D-printed surfaces. Nevertheless, because of the local nature of distortions, the direct application of the global entropy does not lead to satisfactory results of automatic surface quality assessment. Therefore, the extended method, based on the combination of the local image entropy and its variance with additional colour adjustment, is proposed in the paper, leading to the proper classification of 78 samples used during the experimental verification of the proposed approach.
Take-over expectation and criticality in Level 3 automated driving: a test track study on take-over behavior in semi-trucks
Authors: Lotz Alexander , Russwinkel Nele , Wohlfarth Enrico 
Published: March 2020

AbstractWith the introduction of advanced driving assistance systems managing longitudinal and lateral control, conditional automated driving is seemingly in near future of series vehicles. While take-over behavior in the passenger car context has been investigated intensively in recent years, publications on semi-trucks with professional drivers are sparse. The effects influencing expert drivers during take-overs in this context lack thorough investigation and are required to design systems that facilitate safe take-overs. While multiple findings seem to cohere in passenger cars and semi-trucks, these findings rely on simulated studies without taking environments as found in the real world into account. A test track study was conducted, simulating highway driving with 27 professional non-affiliated truck drivers. The participants drove an automated Level 3 semi-truck while a non-driving-related task was available. Multiple time critical take-over situations were initiated during the drives to investigate four main objectives regarding driver behavior. (1) With these results, comparison of reaction times and behavior can be drawn to previous simulator studies. The effect of situation criticality (2) and training (3) of take-over situations is investigated. (4) The influence of warning expectation on driver behavior is explored. Results obtained displayed very quick time to hands on steering and time to first reaction all under 2.4 s. Highly critical situations generate very quick reaction times M = 0.81 s, while the manipulation of expectancy yielded no significant variation in reaction times. These reaction times serve as a reference of what can be expected from drivers under optimal take-over conditions, with quick reactions at high speed in critical situations.
Genetic diversity of provitamin-A cassava (Manihot esculenta Crantz) in Sierra Leone
Authors: Kamanda I. , Blay E. T. , Asante I. K. , Danquah A. , Ifie B. E. , Parkes E. , Kulakow P. , Rabbi I. , Conteh A. , Kamara J. S. , Mensah H. K. , Whyte J. B. A. , Sesay Sayo 
Published: March 2020

AbstractUnderstanding the genetic diversity among accessions and germplasm is an important requirement for crop development as it allows for the selection of diverse parental combinations for enhancing genetic gain in varietal selection, advancement and release. The study aimed to characterize 183 provitamin A cassava (Manihot esculentaCrantz) accessions and five Sierra Leonean varieties using morphological traits, total carotenoid content and SNP markers to develop a collection for conservation and further use in the cassava breeding program. Both morphological parameters and 5634 SNP markers were used to assess the diversity among the provitamin-A cassava accessions and varieties. Significant differences were observed among the accessions for most of the traits measured. The first five PCs together accounted for 70.44% of the total phenotypic variation based on yield and yield components among the 183 provitamin-A cassava accessions and five Sierra Leonean varieties. The present study showed that provitamin-A cassava accessions in Sierra Leone have moderate to high diversity based on morphological and molecular assessment studies. The similarity index among the 187 and 185 cassava accessions grouped them into 6 and 9 distinct clusters based on morphological and molecular analyses, respectively. A significant positive, but low correlation (r = 0.104;p < 0.034), was observed between the two dendrograms. The results obtained will serve as a guide and basis of germplasm management and improvement for total carotenoid content, yield and African cassava mosaic disease resistance in Sierra Leone.
Type 2 diabetes – unmet need, unresolved pathogenesis, mTORC1-centric paradigm
Authors: Bar-Tana Jacob 
Published: March 2020

AbstractThe current paradigm of type 2 diabetes (T2D) is gluco-centric, being exclusively categorized by glycemic characteristics. The gluco-centric paradigm views hyperglycemia as the primary target, being driven by resistance to insulin combined with progressive beta cells failure, and considers glycemic control its ultimate treatment goal. Most importantly, the gluco-centric paradigm considers the non-glycemic diseases associated with T2D, e.g., obesity, dyslipidemia, hypertension, macrovascular disease, microvascular disease and fatty liver as ‘risk factors’ and/or ‘outcomes’ and/or ‘comorbidities’, rather than primary inherent disease aspects of T2D. That is in spite of their high prevalence (60–90%) and major role in profiling T2D morbidity and mortality. Moreover, the gluco-centric paradigm fails to realize that the non-glycemic diseases of T2D are driven by insulin and, except for glycemic control, response to insulin in T2D is essentially the rule rather than the exception. Failure of the gluco-centric paradigm to offer an exhaustive unifying view of the glycemic and non-glycemic diseases of T2D may have contributed to T2D being still an unmet need. An mTORC1-centric paradigm maintains that hyperactive mTORC1 drives the glycemic and non-glycemic disease aspects of T2D. Hyperactive mTORC1 is proposed to act as double-edged agent, namely, to interfere with glycemic control by disrupting the insulin receptor-Akt transduction pathway, while concomitantly driving the non-glycemic diseases of T2D. The mTORC1-centric paradigm may offer a novel perspective for T2D in terms of pathogenesis, clinical focus and treatment strategy.
Formal institution building in financialized capitalism: the case of repo markets
Authors: Wansleben Leon 
Published: March 2020

AbstractMoney markets are at the heart of financialized capitalism, as those markets that provide the funding liquidity needed for credit creation and leveraged trading. How have these markets evolved, grown, and become critical for larger financial flows? To answer this question, I distinguish an early period of financial globalization marked by regulatory arbitrage, offshoring, deregulation, and informal trading practices from a period of regime-consolidation marked by formal institutionalization. Concentrating on repo markets as the key funding sources for market-based banking, I demonstrate that new institutional arrangements for these markets were initiated by private sector associations, but supported and authorized by public authorities. Bond trader groups codified new contractual arrangements and these were validated via reforms of bankruptcy codes and changes in central banks’ policy frameworks in the United States and European Union. Through these modifications and re-articulations in institutional conditions, transactions and large exposures on money markets became routine affairs—for shadow banking actors like money market funds as well as for commercial banks. The article concludes by discussing the continuity of regime-consolidation efforts after the transatlantic financial crisis and hypothesizes that they reveal “neo-patrimonial” features.
Effect of Bariatric Surgery on Diagnosed Chronic Kidney Disease and Cardiovascular Events in Patients with Insulin-treated Type 2 Diabetes: a Retrospective Cohort Study from a Large UK Primary Care Database
Authors: Alkharaiji Mohammed , Anyanwagu Uchenna , Donnelly Richard , Idris Iskandar 
Published: March 2020

Abstract
Aims
To compare the effect of bariatric surgery on renal, chronic kidney disease (CKD) and cardiovascular (CV) outcomes among obese patients with insulin-treated type 2 diabetes (T2D) with and without microalbuminuria (i.e., uACR > 3.0 mg/mmol).

Methods
A retrospective cohort study was conducted among 11,125 active patients with T2D from The Health Improvement Network (THIN) database. Propensity score matching (up to 1:6 ratio) was used to identify patients who underwent bariatric surgery (N = 131) with a non-bariatric cohort (N = 579). Follow-up was undertaken for 10 years (6487 person-years) to compare differences in risk of cardiovascular events and in renal outcomes.

Results
For the matched cohort at baseline: mean age 52 ± 13 years (60% female); weight 116 ± 25 kg, body mass index (BMI) 41 ± 9kg/m2, estimated glomerular filtration rate (eGFR); 70.4 ± 20 mL/min/1.73 m2, and median albumin-creatinine ratio (uACR) 2.0 mg/mmol (interquartile range (IQR): 0.9–5.2 mg/mmol). Bariatric surgery was associated with a 54% reduction in developing CKD compared to their matched non-bariatric cohort (adjusted hazard ratio [aHR]: 0.46; 95%CI: 0.24–0.85, P = 0.02). Among patients with microalbuminuria at baseline, bariatric surgery was protective against CKD (aHR: 0.42, 95%CI: 0.18–0.99, P = 0.050). eGFR was significantly increased from baseline favouring the bariatric group during 75% of the follow-up time (calculated mean difference between groups: 4.1 mL/min/1.73 m2; P < 0.05), especially at 5-year point (74.2 vs 67.8 mL/min/1.73 m2; P < 0.001). However, no significant change was observed with non-fatal CVD episodes (aHR: 0.36, 95%CI: 0.11–1.13, P = 0.079). Albumin levels were significantly reduced throughout the 2 years following the surgery (3.9 vs 4.1 g/dL, P < 0.001). uACR and total protein levels had little or no statistical association to the intervention.

Conclusion
Bariatric surgery may protect patients with diabetes with or without microalbuminuria against the risk of CKD and with a modest protective effect on non-fatal CVD risk. Bariatric surgery is also associated with improvements in overall renal outcomes such as eGFR.
Multicenter, Phase 1, Open Prospective Trial of Gastric Electrical Stimulation for the Treatment of Obesity: First-in-Human Results with a Novel Implantable System
Authors: Paulus G.F. , van Avesaat M. , van Rijn S. , Alleleyn A.M.E , Swain J.M. , Abell T.L , Williams D.B. , Bouvy N.D. , Masclee A.A.M. 
Published: March 2020

AbstractBackground and AimsTo assess safety of the Exilis™ gastric electrical stimulation (GES) system and to investigate whether the settings can be adjusted for comfortable chronic use in subjects with morbid obesity. Gastric emptying and motility and meal intake were evaluated.MethodIn a multicenter, phase 1, open prospective cohort study, 20 morbidly obese subjects (17 female, mean BMI of 40.8 ± 0.7 kg/m2) were implanted with the Exilis™ system. Amplitude of the Exilis™ system was individually set during titration visits. Subjects underwent two blinded baseline test days (GES ON vs. OFF), after which long-term, monthly follow-up continued for up to 52 weeks.ResultsThe procedure was safe, and electrical stimulation was well tolerated and comfortable in all subjects. No significant differences in gastric emptying halftime (203 ± 16 vs. 212 ± 14 min,p > 0.05), food intake (713 ± 68 vs. 799 ± 69 kcal,p > 0.05), insulin AUC (2448 ± 347 vs. 2186 ± 204,p > 0.05), and glucose AUC (41 ± 2 vs.41 ± 2,p > 0.05) were found between GES ON and OFF. At week 4, 13, and 26, a significant (p < 0.01) reduction in weight loss was observed but not at week 52. At this time point, the mean excess weight loss (EWL) was 14.2 ± 4.5%.ConclusionGastric electrical stimulation with the Exilis™ system can be considered as safe. No significant effect on food intake, gastric emptying, or gastric motility was observed. The reduction in weight loss with Exilis™ GES was significant but short lasting. Further electrophysiological research is needed to gain more insight in optimal stimulation parameters and lead localization.
Lipoprotein insulin resistance score and branched-chain amino acids increase after adrenalectomy for unilateral aldosterone-producing adenoma: a preliminary study
Authors: Adolf Christian , Berends Annika M. A. , Connelly Margery A. , Reincke Martin , Dullaart Robin P. F. 
Published: March 2020

AbstractBackground and aimsPrimary aldosteronism (PA) due to unilateral aldosterone-producing adenoma (APA) is preferentially treated by unilateral adrenalectomy (ADX), but little is known about the changes in lipid and glucose metabolism that may occur after ADX.MethodsWe studied 19 non-diabetic patients who did not use lipid-lowering drugs with PA due to APA before and 6 months after unilateral ADX. Fasting plasma lipids, lipoprotein subfractions, branched-chain amino acids (BCAA), and GlycA, a pro-inflammatory glycoprotein biomarker, were measured by nuclear magnetic resonance (NMR) spectroscopy. The Lipoprotein Insulin Resistance (LP-IR) score, which is based on six lipoprotein variables, was calculated.ResultsIn all patients, hyperaldosteronism was resolved after ADX. Body mass index and fasting plasma glucose were unchanged, but HbA1c increased (p = 0.002). Plasma triglycerides, large triglyceride-rich lipoprotein (TRL) cholesterol, and large TRL particles were increased (p < 0.01), resulting in an increase in TRL size (p = 0.027). High-density lipoprotein size was decreased (p = 0.015). LP-IR scores (p = 0.001) and total BCAA (p = 0.017) were increased, but GlycA remained unaltered.ConclusionsBased on increases in LP-IR scores and BCAA, which each have been shown to predict new onset type 2 diabetes mellitus independent of conventional risk factors in the general population, this preliminary study suggests that diabetes risk is not improved but may even be increased after ADX for APA despite remission of PA.