bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stem cell therapies for periodontal tissue regeneration: a network meta-analysis of preclinical studies
Authors: Li Qiang , Yang Guangwen , Li Jialing , Ding Meng , Zhou Na , Dong Heng , Mou Yongbin 
Published: October 2020

AbstractBackgroundPeriodontal tissue regeneration (PTR) is the ultimate goal of periodontal therapy. Currently, stem cell therapy is considered a promising strategy for achieving PTR. However, there is still no conclusive comparison that distinguishes clear hierarchies among different kinds of stem cells.MethodsA systematic review and network meta-analysis (NMA) was performed using MEDLINE (via PubMed), EMBASE, and Web of Science up to February 2020. Preclinical studies assessing five types of stem cells for PTR were included; the five types of stem cells included periodontal ligament-derived stem cells (PDLSCs), bone marrow-derived stem cells (BMSCs), adipose tissue-derived stem cells (ADSCs), dental pulp-derived stem cells (DPSCs), and gingival-derived stem cells (GMSCs). The primary outcomes were three histological indicators with continuous variables: newly formed alveolar bone (NB), newly formed cementum (NC), and newly formed periodontal ligament (NPDL). We performed pairwise meta-analyses using a random-effects model and then performed a random-effects NMA using a multivariate meta-analysis model.ResultsSixty preclinical studies assessing five different stem cell-based therapies were identified. The NMA showed that in terms of NB, PDLSCs (standardized mean difference 1.87, 95% credible interval 1.24 to 2.51), BMSCs (1.88, 1.17 to 2.59), and DPSCs (1.69, 0.64 to 2.75) were statistically more efficacious than cell carriers (CCs). In addition, PDLSCs were superior to GMSCs (1.49, 0.04 to 2.94). For NC, PDLSCs (2.18, 1.48 to 2.87), BMSCs (2.11, 1.28 to 2.94), and ADSCs (1.55, 0.18 to 2.91) were superior to CCs. For NPDL, PDLSCs (1.69, 0.92 to 2.47) and BMSCs (1.41, 0.56 to 2.26) were more efficacious than CCs, and PDLSCs (1.26, 0.11 to 2.42) were superior to GMSCs. The results of treatment hierarchies also demonstrated that the two highest-ranked interventions were PDLSCs and BMSCs.ConclusionPDLSCs and BMSCs were the most effective and well-documented stem cells for PTR among the five kinds of stem cells evaluated in this study, and there was no statistical significance between them. To translate the stem cell therapies for PTR successfully in the clinic, future studies should utilize robust experimental designs and reports.
Laccase-catalyzed derivatization of 6-aminopenicillanic, 7-aminocephalosporanic and 7-aminodesacetoxycephalosporanic acid
Authors: Mikolasch Annett , Hammer Elke , Witt Sabine , Lindequist Ulrike 
Published: October 2020

AbstractTrametes spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of 6-aminopenicillanic, 7-aminocephalosporanic, and 7-aminodesacetoxycephalosporanic acid with 2,5-dihydroxybenzoic acid derivatives to form new penicillin and cephalosporin structures, respectively. The heteromolecular hybrid dimers are formed by nuclear amination of the p-hydroquinones with the primary amines and inhibited in vitro the growth of Staphylococcus species, including some multidrug-resistant strains.
On Hyers–Ulam stability of a multi-order boundary value problems via Riemann–Liouville derivatives and integrals
Authors: Ben Chikh Salim , Amara Abdelkader , Etemad Sina , Rezapour Shahram 
Published: October 2020

AbstractIn this research paper, we introduce a general structure of a fractional boundary value problem in which a 2-term fractional differential equation has a fractional bi-order setting of Riemann–Liouville type. Moreover, we consider the boundary conditions of the proposed problem as mixed Riemann–Liouville integro-derivative conditions with four different orders which cover many special cases studied before. In the first step, we investigate the existence and uniqueness of solutions for the given multi-order boundary value problem, and then the Hyers–Ulam stability is another notion in this regard which we study. Finally, we provide two illustrative examples to support our theoretical findings.
Estimation of bulk permittivity of the Moon’s surface using Lunar Radar Sounder on-board Selenological and Engineering Explorer
Authors: Hongo Keigo , Toh Hiroaki , Kumamoto Atsushi 
Published: October 2020

AbstractSite-dependent bulk permittivities of the lunar uppermost media with thicknesses of tens to hundreds meters were estimated based on the data from Lunar Radar Sounder onboard the Selenological and Engineering Explorer (SELENE). It succeeded in sounding almost all over the Moon’s surface in a frequency range around 5 MHz to detect subsurface reflectors beneath several lunar maria. However, it is necessary to estimate the permittivity of the surface regolith of the Moon in order to determine the actual depths to those reflectors instead of apparent depths assuming a speed of light in the vacuum. In this study, we determined site-dependent bulk permittivities by two-layer models consisting of a surface regolith layer over a half-space with uniform, but different physical properties from the layer above. Those models consider the electrical conductivity as well as the permittivity, whose trade-off was resolved by utilizing the correlation between iron–titanium content and measured physical properties of lunar rock samples. Distribution of the iron–titanium content on the Moon’s surface had already been derived by spectroscopic observation from SELENE as well. Four lunar maria, Mare Serenitatis, Oceanus Procellarum, Mare Imbrium, and Mare Crisium, were selected as regions of evident reflectors, where we estimated the following four physical properties of each layer, i.e., bulk permittivity, porosity, loss tangent and electrical conductivity to conclude the actual depths of the reflectors are approximately 200 m on average. The bulk permittivity ranges from 2.96 at Mare Imbrium to 6.37 at Oceanus Procellarum, whereas the porosity takes the values between 1.8 and 41.1% in the respective maria. It was found that although the bulk permittivity of the four lunar maria differs from a mare to a mare, it shows a good correlation with their composition, viz., their iron–titanium content.
The application of texture quantification in hepatocellular carcinoma using CT and MRI: a review of perspectives and challenges
Authors: Masokano Ismail Bilal , Liu Wenguang , Xie Simin , Marcellin Dama Faniriantsoa Henrio , Pei Yigang , Li Wenzheng 
Published: October 2020

AbstractRecently, radiomic texture quantification of tumors has received much attention from radiologists, scientists, and stakeholders because several results have shown the feasibility of using the technique to diagnose and manage oncological conditions. In patients with hepatocellular carcinoma, radiomics has been applied in all stages of tumor evaluation, including diagnosis and characterization of the genotypic behavior of the tumor, monitoring of treatment responses and prediction of various clinical endpoints. It is also useful in selecting suitable candidates for specific treatment strategies. However, the clinical validation of hepatocellular carcinoma radiomics is limited by challenges in imaging protocol and data acquisition parameters, challenges in segmentation techniques, dimensionality reduction, and modeling methods. Identification of the best segmentation and optimal modeling methods, as well as texture features most stable to imaging protocol variability would go a long way in harmonizing HCC radiomics for personalized patient care. This article reviews the process of HCC radiomics, its clinical applications, associated challenges, and current optimization strategies.
RETRACTED ARTICLE: LncRNA HCG11 regulates proliferation and apoptosis of vascular smooth muscle cell through targeting miR-144-3p/FOXF1 axis in atherosclerosis
Authors: Liu Yi , Cui Xiyun , Wang Cong , Zhao Sihai 
Published: October 2020

AbstractBackgroundAtherosclerosis (AS) is the main pathological basis of coronary heart disease, cerebral infarction and peripheral vascular disease, which seriously endanger people’s life and health. In recent years, long non-coding RNA (lncRNA) has been found to be involved in gene expression regulation, but the research on AS is still in the initial stage. In this study, we mainly studied the role of HCG11 in patients with AS. Quantitative Real-time Polymerase Chain Reaction (QRT-PCR) was used to detect the expression of HCG11 and miR-144 in the serum of AS patients and healthy volunteers. Oxidation Low Lipoprotein (Ox-LDL), interleukin-6 (IL-6) and tumor necrosis factor α (TNF α) radiation were used to establish human vascular smooth muscle cells (VSMCs) in vitro model. Cell proliferation was determined by Cell Counting Kit-8 (CCK-8) assay. The apoptosis rate was determined by flow cytometry (FACS) and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling assay (TUNEL) staining. The expression levels of Forkhead box protein F1 (FOXF1), B cell lymphoma-2 (Bcl-2) and BCL2-Associated X (Bax) were detected by qRT-PCR. Luciferase gene reporter and RNA pull down experiments confirmed the relationship between HCG11 and miR-144, miR-144 and FOXF1.ResultsThis study showed that HCG11 was significantly upregulated in patients with AS, while miR-144 was down-regulated in patients with AS. Ox-LDL and IL-6 in VSMCs induced up-regulation of HCG11 and down-regulation of miR-144. Overexpression of HCG11 promoted the proliferation and inhibited apoptosis of VSMCs. Luciferase gene reporter gene assay showed that HCG11 could bind to miR-144, and miR-144 could bind to FOXF1. Overexpression of miR-144 reversed the effect of HCG11 on VSMCs.ConclusionsLncRNA HCG11 regulates proliferation and apoptosis of vascular smooth muscle cell through targeting miR-144-3p/FOXF1 axis.
Four cases of laparoscopic colectomy for sigmoid colon and rectal cancer with persistent descending mesocolon
Authors: Furuichi Yumi , Kumamoto Kensuke , Asano Eisuke , Kondo Akihiro , Uemura Jun , Suto Hironobu , Oshima Minoru , Kishino Takayoshi , Usuki Hisashi , Okano Keiichi , Suzuki Yasuyuki 
Published: October 2020

Abstract
Background
Persistent descending mesocolon (PDM) is a congenital anomaly associated with the failure of fixation of the descending colon to the lateral abdominal wall. In the laparoscopic colectomy for colorectal cancer, it has been noticed that there are extensive adhesions and a distinctive anatomy of colonic vessels in cases with PDM. Therefore, it is necessary to have sufficient knowledge about PDM so that it can be appropriately treated during surgery.

Case presentation
Case 1—a 79-year-old man underwent laparoscopic intersphincteric resection for rectal cancer. Preoperative barium enema (BE) revealed that the sigmoid colon was located at the right side of the abdomen. An enhanced computed tomography (CT) showed that the common trunk of the left colic artery (LCA) and the first sigmoid colonic artery (S1) branched from the inferior mesenteric artery (IMA). Case 2—a 68-year-old man underwent laparoscopic sigmoidectomy for sigmoid colon cancer and laparoscopic distal gastrectomy for gastric cancer synchronously. BE showed that the descending colon ran from the splenic flexure to medial caudal side. An enhanced CT showed that the distance from the LCA to the marginal artery was 1.0 cm. Case 3—a 68-year-old man underwent laparoscopic low anterior resection for rectal cancer. BE showed that the descending colon ran to the medial caudal side. An enhanced CT showed that the mesentery of the descending colon was comparatively shortened. Case 4—a 60-year-old man underwent laparoscopic sigmoidectomy for sigmoid colon cancer. An enhanced CT showed that the descending colon ran to the medial caudal side and predicted that the LCA and S1 formed a common trunk and branched radially from the IMA. We reported four cases with PDM recognized preoperatively as above. Three cases had a shortening of the mesocolon. While dissecting the vessels, although special attention was required to maintain the blood flow to the intestine, none of these cases developed any complications during the postoperative course.

Conclusions
We considered that it is important to have positional awareness of the LCA and the marginal artery to perform the laparoscopic surgery safely when a colorectal cancer with PDM is diagnosed preoperatively using imaging methods.
Simultaneous triple cancer of the esophagus, pancreas and rectum treated with multimodal strategies: a case report
Authors: Imamura Hiroki , Hirose Hajime , Endo Shunji , Hashimoto Yasuji , Takeda Masashi , Kidogami Shinya , Mokutani Yukako , Kishimoto Tomoya , Yoshioka Shinichi , Tamura Shigeyuki , Sasaki Yo 
Published: October 2020

Abstract
Background
Due to the development of diagnostic imaging technology, we have increased chance of detecting multiple primary cancers. However, simultaneous triple cancer is still a very rare finding whose frequency is not yet known. Treatment of simultaneous triple cancer is a clinical challenge because it requires multimodal strategies including surgery, chemotherapy and radiotherapy.

Case presentation
Here, we present the case of a 74-year-old male with triple cancer involving esophageal and pancreatic cancer, and rectal carcinoma. Each cancer was surgically resectable, but simultaneous resection of all cancers seemed to cause too much surgical stress for the patient. First, we performed a laparoscopic Hartmann’s operation for rectal cancer to minimize the risk of postoperative complications. Then treatment for pancreatic cancer was initiated by administering neoadjuvant chemotherapy with gemcitabine plus nab-paclitaxel. The pancreatic tumor shrank in size, so pancreatoduodenectomy was performed. We chose S-1 as adjuvant chemotherapy. The esophageal cancer showed regression during the treatment of the other two cancers, likely because the chemotherapeutic agents administered for pancreatic cancer had some effect on the esophageal cancer. Definitive chemoradiotherapy was selected instead of esophagectomy because the patient had already undergone two major surgeries. The patient is still alive nine months after the whole course of treatment with no sign of recurrence.

Conclusions
The treatment of triple cancer requires an elaborate strategy to determine which cancer has to be dealt with first and which can be treated later. An aggressive multimodal treatment strategy may be an important option for a patient with triple cancer.
Can Physical Activity While Sedentary Produce Health Benefits? A Single-Arm Randomized Trial
Authors: Sackner Marvin A. , Lopez Jose R. , Banderas Veronica , Adams Jose A. 
Published: October 2020

Abstract
Background
Sedentary time poses a risk to health. Substituting physical activity for inactivity is obvious but this requires a behavior change. Interventions advocated to decrease uninterrupted physical inactivity (defined as Metabolic Equivalent of Task (METS) less than 1.5) are important. One such intervention is accomplished with the Gentle Jogger (GJ), a low risk motorized wellness device which produces effortless, rapid motion of the lower extremities simulating locomotion or fidgeting. GJ produces health benefits in type 2 diabetes, heart disease, and high blood pressure. The purpose of this trial was to ascertain whether GJ increases METS above 1.5 to explain its effectiveness despite sedentary behavior or whether tapping is responsible.

Methods
A randomized single-arm trial was conducted. Subjects were randomized to begin the study in either the supine or seated postures and on the same day crossed over with the starting posture reversed. Oxygen consumption was measured at rest and during GJ.

Results
Twenty-six subjects were studied (15 women and 11 men) with a mean age of 44 ± 15 years and BMI 27.9 ± 5.0, 19 were overweight or obese, and 7 had normal BMI. GJ increased oxygen consumption and METS 15% in the seated posture and 13% in the supine posture. No individual receiving GJ achieved METS exceeding 1.5.

Conclusions
In a moderately obese population, GJ in seated or supine posture did not exceed 1.5 METS. The values are comparable to those reported for sit-stand interventions and cannot explain the health benefits of GJ.

Trial registration
ClinicalTrials.gov, NCT03602365. Registered on July 26, 2018
On migration, geography, and epistemic communities
Authors: King Russell 
Published: October 2020

AbstractThis commentary paper starts by questioning the assumption that migration means international migration, and goes on to affirm that migration studies has indeed come of age as a coherent if highly diverse research field. Several emerging epistemic communities are identified: migration and development; gender and migration; lifestyle migration; and youth and student migrations. Finally, I argue that the role of geography in the study of migration has been under-valued.
An IMISCOE effect? The role of a network of excellence in developing European migration research in the twenty-first century
Authors: Levy Nathan 
Published: October 2020

AbstractIMISCOE, it is argued, has played a key role in institutionalising migration studies. This commentary explores the bibliometric data from the opening article of this series to examine this claim more deeply, and finds indications of an ‘IMISCOE effect’. The network is increasingly prominent in the field; it has established a ‘citation community’ among its members; it has been a key part of the internationalisation of the field. Its influence is unlikely to decline, which is also a point of caution, namely, that the ‘IMISCOE effect’ does not belie the diversity of perspectives in migration research that exist within and beyond the network.
Severe COVID-19: what have we learned with the immunopathogenesis?
Authors: Bordallo Bruno , Bellas Mozart , Cortez Arthur Fernandes , Vieira Matheus , Pinheiro Marcelo 
Published: October 2020

AbstractThe COVID-19 outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global major concern. In this review, we addressed a theoretical model on immunopathogenesis associated with severe COVID-19, based on the current literature of SARS-CoV-2 and other epidemic pathogenic coronaviruses, such as SARS and MERS. Several studies have suggested that immune dysregulation and hyperinflammatory response induced by SARS-CoV-2 are more involved in disease severity than the virus itself.Immune dysregulation due to COVID-19 is characterized by delayed and impaired interferon response, lymphocyte exhaustion and cytokine storm that ultimately lead to diffuse lung tissue damage and posterior thrombotic phenomena.Considering there is a lack of clinical evidence provided by randomized clinical trials, the knowledge about SARS-CoV-2 disease pathogenesis and immune response is a cornerstone to develop rationale-based clinical therapeutic strategies. In this narrative review, the authors aimed to describe the immunopathogenesis of severe forms of COVID-19.
Structure, stratigraphy, and petroleum potential of the deepwater Colombian Basin, offshore northern Colombia
Authors: Leslie Stephen C. , Mann Paul 
Published: October 2020

We have defined the structure and stratigraphy of the central area of the Colombian Basin — offshore of the northern Caribbean coast of Colombia — using approximately 8400 line km of depth-converted 2D seismic data assembled from academic and industry sources. We integrate information from offset deep sea drilling program and ocean drilling program wells into a structural and stratigraphic model of the Colombian Basin, identifying the key elements of a petroleum system. These elements are (1) Upper Cretaceous marine shale source rock, (2) Middle to Upper Miocene (16–5.3 Ma) basin-floor fans associated with the Magdalena fan turbidite system, (3) structural traps and stratigraphic traps, and (4) sealing intervals formed by Miocene hemipelagic marine shale associated with sea-level high-stands. We extend a previously recognized trap type for the Colombian margin to include stratigraphic traps within the distal Miocene Magdalena fan section. We base our interpretations upon seismic observations of amplitude anomalies conformant with structures; fluid migration pathways along faults; and bright, laterally continuous, and low-impedance seismic reflectors. The primary risk for the exploration potential of the area is the presence of a laterally extensive Upper Cretaceous source rock within the main Colombian basin depocenter. The 1D burial history models and 3D basin modeling indicate that a source rock of this age and at this stratigraphic level would have expelled hydrocarbons during Middle to Late Miocene from the deepest part of the basin and may continue to expel hydrocarbons in the present day.
Are bright spots always hydrocarbons? A case study in the Taranaki Basin, New Zealand
Authors: Reilly Peter , Clairmont Roberto , Bedle Heather 
Published: October 2020

In the shallower regions of the 3D Nimitz seismic survey, there exist multiple interesting bright seismic amplitude anomalies. These anomalies, or funny looking things, occur in a confined spatial and temporal region of the seismic. They have a concave-up seismic appearance along the cross section. Bright seismic amplitudes can be a direct hydrocarbon indicator, or they can be representative of strong lithologic contrasts and/or acquisition artifacts. We have set out to investigate misinterpreted seismic anomalies along cross-sectional lines. Therefore, we apply seismic attributes to indicate that these bright spot features, which we interpret to be submarine gullies looking along time-slice intersections, can possibly be mistaken for hydrocarbon anomalies in a cross-sectional view. However, we cannot fully rule out the presence of hydrocarbons because it is common for gas sands to create similar anomalies. Previously drilled wells within the survey (Korimako-1 and Tarapunga-1) point to a lack of hydrocarbon potential in the subsurface. Although it is possible that these bright spots are due to hydrocarbon presence, we develop a more likely hypothesis: The lithology of the interfluve sediments is similar to the gully-margin drapes but differs from the gully sediment fill. Funny looking thing (FLT): Submarine gullies Seismic appearance: High-amplitude spotted features Alternative interpretations: Lithologic anomalies, gas seeps, bright spots Features with a similar appearance: Gas accumulation, sediment fills in limestone paleocaves Formation: Giant Foresets Formation Age: Pleistocene Location: Taranaki Basin, New Zealand Seismic data: Nimitz 3D (cropped volume) Analysis tools: Curvature, instantaneous frequency, and sweetness attributes; well reports