bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between gastric content fluidity and pars oesophageal ulcers in nursery pigs: a cross-sectional study of high-risk Danish herds using commercial feed ad libitum
Authors: Peralvo-Vidal Juan Miguel , Weber Nicolai Rosager , Nielsen Jens Peter , Denwood Matthew , Haugegaard Svend , Pedersen Anni Øyan 
Published: November 2020

Abstract
Background: The objective of this cross-sectional study was to assess the within-herd prevalence of pars oesophageal ulcers (POU) in high-risk Danish herds using commercial diets fed ad libitum. Furthermore, we aimed to estimate the association between gastric content fluidity and POU using a generalised additive model (GAM). The study included 200 clinically healthy nursery pigs randomly selected from ten farms (20 pigs from each farm). The 10 farms were selected based on a suspected high prevalence of gastric ulcers. Post-mortem gastric ulcer assessment was based on macroscopic lesions, and gastric content fluidity was assessed based on the solid particle sedimentation percentage (solid phase). Results: We observed an overall prevalence of 35.5% for POU in nursery pigs. Within-herd prevalence varied considerably among farms, with values ranging from 0% in Farm 1 to 84% in Farm 4. Our model showed strong associations between POU and gastric content fluidity (P<0.001), as well as between POU and farm of origin (P<0.001). In addition, we observed that the risk of POU decreased non-linearly as the gastric content solid phase percentage increased, i.e. as the gastric content became more solid. Conclusion: We have demonstrated that pars oesophageal ulcers are present in Danish herds with nursery pigs fed commercial diets ad libitum. Furthermore, we have established that gastric content fluidity is strongly associated with POU in nursery pigs. Even so, we cannot conclude that gastric content fluidity is solely responsible for POU. Future research should look into the association between pars oesophageal ulcers and both farm management activities and individual pig factors.
Dynamic Changes in Plasma Mitochondrial DNA Concentration in Patients with Severe Acute Pancreatitis
Authors: Duan Zepeng , Wang Yujing , Ling Hua , Li Qiong , Dai Xingui 
Published: November 2020

Abstract
Background: The elevated plasma mitochondrial DNA (mtDNA) is associated with prognosis in patients with severe acute pancreatitis (SAP). However, it is not clear that the dynamic process of plasma mtDNA during the early stage of SAP and the correction between mtDNA and clinical features.Methods: Twenty-six eligible patients with SAP in the general intensive care unit of our institution were enrolled in this study. The mtDNA concentration were assessed at admission and on days 3, 5, and 7.Results: The mtDNA concentration of the patients with SAP was elevated at each time point compared with that in the healthy controls. The mtDNA levels increased rapidly, peaking on day 3 after admission, and began to decrease on day 5. The trend remained statistically consistent among the acute physiology and chronic health evaluation (APACHE II) score, the sequential organ failure assessment (SOFA) score, C-reactive protein (CRP) levels and mtDNA levels. Contrastingly, the changes were not statistically consistent among the procalcitonin (PCT), calciumion (Ca2+) and mtDNA concentrations. The mtDNA level correlated significantly with the APACHE II score, SOFA score, and Ranson score, but not with the CRP, PCT, and Ca2+ concentrations. Conclusions: The dynamic change of plasma mtDNA correlated significantly with SAP development. The elevated mtDNA levels could be used as a biomarker for the early stage of SAP.Trial registration: NCT: 04079777. Registered 4 September 2019 - Retrospectively registered, https://register.clinicaltrials.gov/prs/app/action/SelectProtocol?sid=S00096E5&selectaction=Edit&uid=U0002O5I&ts=2&cx=-e6bci8
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Oral Doses of Bi 187004, an Inhibitor of 11beta-hydroxysteroid Dehydrogenase-1, in Healthy Male Volunteers With Overweight or Obesity
Authors: Bianzano Susanna , Heise Tim , Jungnik Arvid , Schepers Cornelia , Schoelch Corinna , Gräfe-Mody Ulrike 
Published: November 2020

Abstract
BackgroundThe study characterizes safety, tolerability, pharmacokinetic and pharmacodynamic profiles of single rising doses of the 11beta-hydroxysteroid dehydrogenase-1 (11beta-HSD1) inhibitor BI 187004 in healthy men with overweight or obesity.MethodsThis was a randomized, double-blind, parallel group, placebo-controlled study with administration of 2.5-360 mg BI 187004 or placebo once daily as single dose in 72 healthy volunteers with overweight or obesity.Assessments included 11beta-HSD1 inhibition in the liver (assessed indirectly by urinary tetrahydrocortisol/tetrahydrocotisone ratio) and in subcutaneous adipose tissue ex vivo and determination of hypothalamus-pituitary-adrenal axis hormones.ResultsBI 187004 was well tolerated and safe in all tested dose groups. The incidence of drug-related adverse events was 16.7% (n=9) for all 9 BI 187004 dose groups and 5.9% (n=1) for placebo. All treatment groups were similar concerning kind and intensity of adverse events. No clinically relevant deviations in clinical laboratory or ECG parameters were reported. Exposure of BI 187004 increased non‑proportionally over the entire dose range tested. The geometric mean apparent terminal half-life decreased from 33.5h (5 mg) to 14.5h (160 mg) remaining stable up to 360 mg. Renal excretion of BI 187004 was low (3-5%). Urinary tetrahydrocortisol/tetrahydrocotisone ratio decreased, indicating liver 11beta-HSD1 inhibition. Median inhibition of 11beta-HSD1 in subcutaneous adipose tissue biopsies following single dosing ranged from 86.8% (10 mg) to 99.5% (360 mg) after 10h and from 59.4% (10 mg) to 98.6% (360 mg) after 24h. ConclusionsBI 187004 as single dose was safe and well tolerated and is suitable for once daily dosing. There was significant, sustained 11beta-HSD1 inhibition in liver and adipose tissue. Trial registry number: ClinicalTrials.gov, NCT01587417, registered on 26-Apr-2012, https://clinicaltrials.gov/ct2/show/study/NCT01587417
WITHDRAWN: Effects of Lizardite Addition on Technological Properties of Forsterite-Monticellite Rich White Ceramics Prepared From Natural Magnesite and Dolomite
Authors: Manni Ahmed , Harrati Achraf , Haddar Abdelilah El , Chari Abdelwahed , Sdiri Ali , Hassani Fahd Oudrhiri , Bouari Abdeslam El , Hassani Iz-Eddine El Amrani El , Sadik Chaouki 
Published: November 2020

Abstract
Lizardite rich peridotite has never been used to prepare ceramic specimens, especially in Morocco. For this raison, potential use of naturally abundant lazirditic material from the Rif domain (NW morocco), as a supply for ceramic industry, has been evaluated. The effects of lizardite addition to magnesite and dolomite mixtures on the thermomechanical properties of the calcined ceramics were also detailed. To achieve this target, natural lizardite, magnesite and dolomite samples were collected in ultrabasic Beni Bousra massif. Those raw samples were used for the synthesis of a forsterite-monticellite rich ceramics. Both raw and sintered samples were characterized by x-ray diffraction (XRD), scanning electron microscope (SEM) and fourier transform infrared (FTIR). Main physical and mechanical properties were assessed and correlated to their respective microstructural changes. The obtained results showed that both magnesite and dolomite were mainly composed of MgCO3 and CaCO3. In contrast, lizardite sample showed high amounts of silica, magnesia and iron oxide. Technological tests indicated that the prepared mixtures had increased flexural strengths. An increased amount of lizardite in the initial mixtures enhanced mechanical properties of the prepared ceramic specimens. The same data showed that lizardite has led to a decrease in linear shrinkage during calcination and subsequently, the production of ceramics with the required technological properties. Thus, the preparation of lizardite-based ceramics from the raw material deposits of the Rif area, Morocco, is technically feasible, economically justifiable and socially desirable due to the contribution to the economic growth of the raw materials sector, especially ceramic industry.
iTRAQ-Based Sperm Proteomic&nbsp;Analyses Reveals Candidate Proteins Affecting the Quality of Spermatozoa From Boar on Plateaus
Authors: Zhao Yanling , Wang Yaomei , Guo Feipeng , Lu Bo , Sun Jiale , Wang Jianzhou , Ren Zili 
Published: November 2020

Abstract
Background: Tibetan pigs (TP) exhibit heritable adaptations to their hypoxic environments as a result of natural selection. Whereas, what candidate proteins affecting the sperm quality of boar on plateaus has not been clearly investigated yet. Methods: In this study, to reveal the candidate proteins affecting the quality of spermatozoa from boar on plateaus, we analyzed the sperm quality by Computer-assisted semen analysis (CASA) system and Reactive oxygen species (ROS) levels, compared the sperm proteomes between TP and Yorkshire pigs (YP) raised at high altitudes using the isobaric tags for relative and absolute quantitation (iTRAQ) in combination with the liquid chromatography-tandem mass spectrometry (LC-MS/MS) proteomic method, and confirmed the relative expression levels of the four proteins by western blot. Results: The sperm quality of the TP was superior to that of the YP on plateaus. Of 1,555 quantified proteins, 318 differentially expressed proteins (DEPs) were identified. Gene ontology (GO) analysis revealed that the DEPs were predominantly associated with the sorbitol metabolic process, removal of superoxide radicals, cellular response to superoxide, response to superoxide and regulation of the mitotic spindle assembly. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were mainly enriched in pathways involved in the regulation of the actin cytoskeleton, glutathione metabolism, oxidative phosphorylation, and estrogen signaling. And based on the protein-protein interaction (PPI) network analysis, we identified 8 candidate proteins (FN1, EGF, HSP90B1, CFL1, GPX4, NDUFA6, VDAC2, and CP) that might play important roles that affect the sperm quality of boar on plateaus. Moreover, the relative expression levels of the proteins (CFL1, EGF, FN1, and GPX4) were confirmed by western blot. Conclusions: Our results reveal 8 candidate proteins (FN1, EGF, HSP90B1, CFL1, GPX4, NDUFA6, VDAC2, and CP) affecting the sperm quality of boar on plateaus, providing a reference for studies on improving sperm quality and the molecular breeding of boar on plateaus.
Insights into Preventing Female Genital Mutilation/cutting in Sri Lanka: A Qualitative Interpretative Study.
Authors: Dawson Angela , Wijewardene Kumudu 
Published: November 2020

Abstract
Background: FGM/C is a cultural practice associated with adverse health outcomes that involves the partial or complete removal of the external female genitalia or injury to the genitalia. FGM/C is a form of violence against women and girls. There are no laws that specifically outlaw FGM/C in Sri Lanka and no national prevalence data. There is a lack of evidence about this practice to inform prevention efforts required to achieve the Sustainable Development Goal (SDG) target 5.3.2, that focuses on the elimination of all harmful practices including FGM/C. Methods: We undertook a qualitative interpretative study to explore the knowledge and perceptions of community members, religious leaders and professionals from the health, legal and community work sectors in five districts across Sri Lanka. We aimed to identify strategies to end this practice. Results: Two-hundred-and twenty one people participated in focus group discussions and key informant interviews. A template analysis identified five top-level themes: Providers, procedures and associated rituals; demand and decision-making; the role of religion; perceived benefits and adverse outcomes; ways forward for prevention. Conclusions: This study delivered detailed knowledge of FGM/C related beliefs, perceptions and practitioners and provided opportunities for the development of an integrated programming strategy that incorporates interventions across three levels of prevention.
The Development of the WHO Labour Care Guide: An International Survey of Maternity Care Providers
Authors: Pingray Veronica , Bonet Mercedes , Berrueta Mabel , Mazzoni Agustina , Belizán María , Keil Netanya , Vogel Joshua , Althabe Fernando , Oladapo Olufemi T. 
Published: November 2020

Abstract
BackgroundThe partograph is the most commonly used labour monitoring tool globally. However, it is used incorrectly or inconsistently in many settings. In 2018, a WHO expert group reviewed and revised the design of the partograph in view of emerging evidence and developed the first version of the Labour Care Guide (LCG). The objective of this study was to explore views and opinions of skilled health personnel on the first version of the WHO Labour Care Guide.MethodsSkilled health personnel (including obstetricians, midwives and general practitioners) of any age and gender from Africa, Asia, Europe and Latin America were identified through a large global research network. Country coordinators from the network invited 5 to 10 mid-level and senior skilled health personnel who have worked in labour wards anytime in the last 5 years. A self-administered, anonymous, structured, online questionnaire including closed and open-ended questions was designed to assess the clarity, relevance, appropriateness of the frequency of recording, and the completeness of the variables on the LCG. ResultsA total of 110 respondents from 23 countries completed the survey between December 2018 and January 2019. Variables included in the LCG were generally considered clear, relevant and with appropriate recording frequency. Most sections of the LCG were considered complete. Respondents agreed or strongly agreed with the overall design, structure of the LCG, and the usefulness of reference thresholds to trigger further assessment and actions. They also agreed that LCG will potentially impact positively on clinical decision-making and respectful maternity care. Respondents disagreed with the value of some variables including coping, urine, and neonatal status.ConclusionsFuture end-users of WHO next generation partograph considered the variables to be clear, relevant and appropriate, and to have the potential to positively impact on clinical decision-making and respectful maternity with minor improvements.
A Systematic Review on International Health Policy and Services Research: A Bibliometric Analysis
Authors: He Anqi , Yu Yan , Zheng Si , kelifa Mohammedhamid Osman , Jiang Junfeng , Wang Peigang 
Published: November 2020

Abstract
Background: The number of research publications on health policy and services has been strikingly increasing. This study aimed to reveal the current status and trends of global research on health policy and services and provide insights for health policy and services research. Methods: Based on the Social Science Citation Index (SSCI) database, research on health policy and services published between 1999 and 2018 were identified. The published journals, temporal trends, collaboration between countries/territories and research institutions, and hotspots in health policy and services’ research were analyzed using bibliometric analysis. Results: The number of health policy and services publications has been continuously increasing since 1999, especially after 2008. Health Affairs, Medical Care, and Health Services Research were the most active journals in this field. Scholars from the United States (US), the United Kingdom (UK) and Canada have published more related publications than other countries. Further, The US produced the largest number of independent and collaborative articles, and it took a central position in the collaboration network and had the greatest number of prolific institutions. Harvard University was the largest contributor of single-institution and collaborative publications and occupied a key position in collaborative networks. A keywords analysis demonstrated that medicare, quality of care, and primary care have always been researched hotspots in this field. The rankings of implementation, patient safety, and disparities have risen the most, suggesting a new research trend in the field since the 21st century. Conclusions: Our study identified the temporal and spatial characteristics, academic collaborations, and hotspots in scientific research output in the area of health policy and services. It can provide insights for health policy and services research and global health governance.
Epidemiological Patterns of Hypertension and Type 2 Diabetes Mellitus in Vietnam. Ecological Study
Authors: Sivčo Patrik , Hoang Giang Nguyen , Melichová Juliana , Plančíková Dominika , Majdan Marek , Rusnák Martin 
Published: November 2020

Abstract
Vietnam is a SEA country with a high burden of NCD and hypertension and diabetes are among the top contributors to premature mortality. The recent reviews reported the rapidly growing prevalence of these two chronic conditions in Vietnam. To investigate the epidemiological burden of HT and DM type 2 in Vietnam an ecological study employing secondary data analysis was conducted. The study was a part of the SUNI SEA project implementation with the aim to put the basis for the research hypothesis for the SUNI SEA project in Vietnam. Data from the Institute of Health Metrics and Evaluation and Vietnamese Health statistics years books were analysed by linear and polynomial regression analyses, Kendall rank correlation and Pearson correlation. On average 19% of all deaths and 9% of all DALYs were associated with high SBP and 2% of all deaths and 2% of all DALYs were attributable to DM type 2 between 1990-2017 in Vietnam. Differences between genders were recognizable mainly in CVDs and high SBP death rates. The decrease in the number of elementary nurses, as well as the increase in health insurance expenditures per inpatient, seems to be with the highest certainty correlated with HT and type 2 DM death and DALYs rates. If the tracked progress remains at the same pace, in the category of Good health and well-being Vietnam seems not to be able to achieve the desired threshold by 2030 as committed by United Nations Member States in 2015. Developing regulatory frameworks and social demand for professionalism in Vietnam could encourage nurses to pursue higher education but the essential role of elementary nurses became more sensible. The health financing reform that shifts resources from hospital care to primary care should be developed to improve access to early diagnosis and chronic care.
Effects of Subjective Successful Aging on Emotional and Coping Responses to the COVID-19 Pandemic
Authors: Yeung Dannii , Chung Edwin , Lam Alfred , Ho Alvin 
Published: November 2020

Abstract
Background: Middle-aged and older adults are more vulnerable to hospitalization and mortality if they are infected with the COVID-19 virus. The present study investigates the longitudinal effects of subjective successful aging on middle-aged and older adults’ emotional and coping responses to the COVID-19 pandemic, and explores an underlying mechanism through perceived time limitation during the pandemic. Methods: A sample of 311 Hong Kong Chinese middle-aged and older adults (Mage=64.58, SD=10.14, Range=45–90 years) were recruited from an Adult Development and Aging Project and participated in a questionnaire study via an online platform or phone interview. Their levels of subjective successful aging, perceived time limitation, and emotional and coping responses to the pandemic were measured.Results: The respondents who perceived themselves as more successful in aging process reported more positive and fewer negative emotions compared with their counterparts with lower levels of subjective successful aging. The mediation analysis showed that perceived time limitation could partially account for the effects of subjective successful aging on emotional and coping responses. Conclusions: Findings of this study unveil the beneficial effects of subjective views of successful aging on emotional and coping responses to the pandemic through alleviating their perception of time limitation.
The potential impact of the COVID-19 pandemic on HIV, tuberculosis, and malaria control in Africa: a systematic review of modelling studies and population surveys
Authors: Amimo Floriano , Lambert Ben , Magit Anthony , Hashizume Masahiro 
Published: November 2020

Abstract
Background We reviewed current evidence on the impact of COVID-19 on HIV, tuberculosis, and malaria across Africa.Methods We searched medical databases up to 15 September 2020 for epidemiological studies that investigated the impact of COVID-19 on HIV, tuberculosis, and malaria in terms of morbidity, mortality, or healthcare accessibility, covering African countries. We consulted global health and government sources for population surveys providing relevant primary data. We employed meta-study to assess evidence. This study is registered with PROSPERO, number CRD42020209265.Results Of the 128 records screened, 14 epidemiological studies were included in the analysis. We identified 5 population surveys. The largest effect of COVID-19 related disruption of HIV, TB, and malaria services is projected to result from interruption of ART, decline in TB case detection, and interruption of insecticide treated bed nets distribution campaigns, respectively. However, most modelling studies substantially underestimated the potential implications of COVID-19 on HIV, TB, and malaria in Africa and focused on the disruption of healthcare resulting from reduction in the capacity of healthcare provider. Reduced capacity of patients to use health services and adhere to treatment may also contribute to poor outcomes even when health systems capabilities are restored or unaffected. Moreover, these models do not account for any potential interaction of HIV, TB, and malaria with COVID-19, although empirical evidence shows that coinfection between HIV and TB with COVID-19 is significantly associated with increased mortality risk in Africa.Conclusions Current evidence is largely speculative. Innovative COVID-19 resilient solutions calibrated to local vulnerabilities are vital to ensure continuity of care and prevent the emergence of further potentially larger crises.