bluuebunny/crossref_metadata_2025_split huggingface dataset:
Additive manufacturing by means of parametric robot programming
Authors: Feucht Thilo , Lange Jörg , Erven Maren , Costanzi Christopher Borg , Knaack Ulrich , Waldschmitt Benedikt 
Published: June 2020

Abstract3D printing or additive manufacturing (AM) is now becoming a common technology in industry. The research activities in this area are constantly increasing, because with the high level of automation and the possibility to produce individual and complex structures, the advantages of additive manufacturing are promising. Most materials used in the construction industry can be used for additive manufacturing, for example steel and concrete. The print head (for example, a welding torch in the AM of steel) is mainly led by industrial robots, whose movements must be transferred from the 3D geometry files to be manufactured. In contrast to all-in-one systems, where hardware, software and printed material are coordinated, most robot-based AM systems are made of components from different manufacturers and branches. The objects to be manufactured are complex and the manufacturing parameters, which significantly influence the geometry and quality of the manufactured part, are manifold. This makes the workflow from the 3D model to the finished object difficult, especially because it is almost impossible to predict the exact manufactured structure geometry or layer height (which would be indispensable for accurate slicing). During the manufacturing process, deviations between the target and actual geometry can occur. In this paper, parametric robot programming (PRP) is presented, which allows flexible motion programming, and a quick and easy reaction to deviations between target and actual geometry during the manufacturing process. Complex geometries are divided into iso-curves whose mathematical functions are determined by means of polynomial regression. The robot can calculate the coordinates to be approached from these functions itself. This allows a simple adjustment of the manufacturing coordinates during the process as soon as target–actual deviations occur. The workflow from the file to the manufactured object is explained. The principle of PRP is transferable and applicable to all robot manufacturers and all conceivable printing processes. In the following article, it will be presented using wire + arc additive manufacturing, in which welding robots or portals can be used to produce steel structures with high deposition rates. Furthermore, the project “AM Bridge 2019” is presented, in which a steel bridge was manufactured in situ over a little creek and the presented PRP was applied.
Regime Change: Education to Work Transitions in England, 1980s–2020s
Authors: Roberts Ken 
Published: June 2020

AbstractThis paper argues the case for viewing a country’s transition regime as a totality in which different career steps and routes assign significance and value to one another. Following the destruction of major sections of Britain’s transition regime in the 1970s and 1980s, the paper explains how the regime has subsequently been reconstructed following the 1988 Education Reform Act, replacing the vocational education and training schemes of the 1980s with government-supported apprenticeships, almost uninterrupted employment growth since 1992, and the financialization of the corporate economy alongside uncapped expansion of higher education. England’s current transition regime keeps rates of youth unemployment and NEET below the European Union averages and delivers the fastest transitions in Europe. However, the reconstructed regime also locks-in features that may well become long-term problems, namely an expensive higher education system which leaves graduates with debts that many do not expect to repay in full, and substantial low wage, low skill, low productivity sectors in the economy and workforce.
AeroVR: An immersive visualisation system for aerospace design and digital twinning in virtual reality
Authors: Tadeja S.K. , Seshadri P. , Kristensson P.O. 
Published: June 2020

ABSTRACTOne of today’s most propitious immersive technologies isvirtual reality(VR). This term is colloquially associated with headsets that transport users to a bespoke, built-for-purpose immersive 3D virtual environment. It has given rise to the field of immersive analytics—a new field of research that aims to use immersive technologies for enhancing and empowering data analytics. However, in developing such a new set of tools, one has to ask whether the move from standard hardware setup to a fully immersive 3D environment is justified—both in terms of efficiency and development costs. To this end, in this paper, we presentAeroVR—an immersive aerospace design environment with the objective of aiding the component aerodynamic design process by interactively visualizing performance and geometry. We decompose the design of such an environment into function structures, identify the primary and secondary tasks, present an implementation of the system, and verify the interface in terms of usability and expressiveness. We deploy AeroVR on a prototypical design study of a compressor blade for an engine.
COVID-19 Susceptibility Mapping Using Multicriteria Evaluation
Authors: Sarkar Showmitra Kumar 
Published: June 2020

ABSTRACTObjective: The purpose of this research was to investigate coronavirus disease (COVID-19) susceptibility in districts of Bangladesh using multicriteria evaluation techniques.Methods: Secondary data were collected from different government organizations, 120 primary surveys were conducted for calculating weights, and results were validated through 12 key people’s interviews. Pairwise comparison matrixes were calculated for 9 factors and subfactors. The analytic hierarchy process used for calculating the susceptibility index and map was prepared based on the results.Results: According to the results, multiple causal factors might be responsible for COVID-19 spreading in Bangladesh. Dhaka might be vulnerable to COVID-19 due to a higher population, population density, and international collaboration. According to the pairwise comparison matrix, the consistency ratio for subfactors and factors was in the permissible limit (ie, less than 0.10). The highest factor weight of 0.2907 was found for the factors type of port. The maximum value for the susceptibility index was 0.435219362 for Chittagong, and the minimum value was 0.076174 for Naogaon.Conclusions: The findings of this research might help the communities and government agencies with effective decision-making.
A Single-Loop MIMO Trajectory Tracking Controller for Autonomous Quadrotors: The Control Point Concept
Authors: Bae Han Woong , Fahimi Farbod 
Published: June 2020

SUMMARYIn this paper, a sliding mode control using a control point concept is proposed for an under-actuated quadrotor. The proposed controller controls the position of the control point, a displaced point from the quadrotor’s geometric center, and the yaw angle. This method solves singularity issues in control matrix inversion and enables the utilization of the multi-input multi-output equation to derive the control inputs. The sliding surface is designed to control four outputs while stabilizing roll and pitch angles. Simulation and experimental results show the effectiveness and robustness of the proposed controller in the tracking of a trajectory under parametric uncertainties.
NICE's evaluations of medicines authorized by EMA with conditional marketing authorization or under exceptional circumstances
Authors: Pinilla-Dominguez Pilar , Naci Huseyin , Osipenko Leeza , Mossialos Elias 
Published: June 2020

ObjectivesTo investigate the impact of the uncertainty stemming from products with European conditional marketing authorization (CMA) or authorization in exceptional circumstances (AEC) on the National Institute for Health and Care Excellence's (NICE) recommendations.MethodsProducts which received CMA/AEC by European Medicines Agency (EMA) up to 1 December 2016 were identified and matched with corresponding NICE decisions issued by August 2017, the status of which was then traced to August 2019. We assessed whether the conversion of CMA to full marketing authorization triggered a review of a NICE decision. The odds of a recommendation carrying a commercial arrangement for products with and without CMA/AEC were calculated.ResultsFifty-four products were granted CMA/AEC by EMA. NICE conducted thirty evaluations of products with CMA/AEC. Twelve products were recommended by NICE by August 2017 and fourteen by August 2019. All recommendations had an associated commercial arrangement. The odds of carrying a commercial arrangement were higher for products with CMA/AEC compared to those with full authorization. Conversions from conditional to full authorization among products not recommended by NICE did not trigger an appraisal review.ConclusionsUncertainty, stemming from the lack of robust clinical data of products authorized with CMA/AEC, has a substantial impact on HTA recommendations, frequently requiring risk mitigation mechanisms such as commercial and data collection arrangements. Further analyses should be conducted to assess whether the benefits of early access strategies outweigh the risks for patients and the healthcare system.
Tricuspid valvuloplasty for isolated tricuspid regurgitation in children
Authors: Wang Guanxi , Ma Kai , Pang Kunjing , Zhang Sen , Qi Lei , Yang Yang , Feng Zicong , Mao Fengqun , Yuan Jianhui , Zhang Hao , Li Shoujun 
Published: June 2020

AbstractBackground:Isolated congenital tricuspid regurgitation other than Ebstein’s anomaly was rare especially for children. The objective of this study was to investigate the clinical characteristics and to assess the results of tricuspid valvuloplasty for children with isolated tricuspid regurgitation.Methods:From January 2010 to June 2019, 10 consecutive patients with isolated tricuspid regurgitation who were unresponsive to drug therapy underwent tricuspid valvuloplasty in our hospital. Patients’ clinical data were analysed retrospectively.Results:Mean age at operation was 48.5 ± 31.0 (range: 9–106) months and mean weight at operation was 16.1 ± 6.9 (range: 8.6–33.0) kg. All patients presented severe isolated tricuspid regurgitation. According to pathological lesions, the main causes accounted for chordae tendinea rupture (3/10), leaflet cleft (2/10), mal-connected chordal tendinea to leaflets (2/10), elongated chordae (1/10) and chordae absent (1/10), and severe anterior leaflet dysplasia (1/10). Individualised tricuspid valvuloplasty was adapted to all of them successfully. Post-operative echocardiography showed no tricuspid regurgitation in two patients and mild regurgitation in eight patients. The cardiothoracic ratios on their chest roentgenograms decreased from 0.59 ± 0.05 to 0.54 ± 0.05. At the latest follow-up (50.4 ± 47.2 months), echocardiography showed that mild to moderate tricuspid regurgitation in seven patients, moderate tricuspid regurgitation in three patients, and no patient with severe tricuspid regurgitation. All patients were in NYHA functional class I.Conclusions:For patients with isolated tricuspid regurgitation who were not well responsive to drug therapy, individualised tricuspid valve repair can achieve an excellent result.
Aortopexy – an effective strategy for relief of left main bronchus compression
Authors: Rajan Saileela , Kalpana Sivasambo , Coelho Robert 
Published: June 2020

AbstractCongenital anomalies of aortic arch and pulmonary arteries can cause airway compression in children. We present a rare case of left main bronchus compression between the right pulmonary artery and descending thoracic aorta, which was successfully treated by aortopexy.
Mental pain and pain-proneness in patients with migraine: results from the PAINMIG cohort-study
Authors: Cosci Fiammetta , Svicher Andrea , Mansueto Giovanni , Benemei Silvia , Chiarugi Alberto , De Cesaris Francesco , Guidi Jenny , Zipfel Stephan 
Published: June 2020

AbstractBackgroundPain has been qualified under four categories: nociception, perception of pain, suffering, and pain behaviors. Most of the literature on migraine has devoted attention to the first two. The aim of the present cohort study was to investigate patients with migraine enrolled at a tertiary care unit to study suffering and mental pain and identify potential risk factors for migraine.MethodsAn observational cross-sectional study was carried out on patients with chronic migraine (CM) and episodic migraine (EM), and healthy subjects (HS). The three groups were matched for age and sex. A comprehensive assessment of migraine disability, pain, psychiatric disorders, psychosomatic syndromes, depressive and anxious symptoms, euthymia, psychosocial variables, mental pain, and pain-proneness (PP) was performed.ResultsThree hundred subjects were enrolled (100 CM, 100 EM, and 100 HS). Based on the multiple regression analyses, those presenting PP (social impairment: odds ratio [OR] = 3.59, 95% confidence interval [CI] = 1.14-11.29; depressive symptoms: OR = 3.82, 95% CI = 1.74-8.41) were more likely to be CM than HS. Those with higher levels of PP (social impairment: OR = 4.04, 95% CI = 1.60-10.22; depressive symptoms: OR = 2.02, 95% CI = 1.26-3.24) were more likely to be EM than HS. Those presenting higher levels of mental pain were more likely to be CM than EM (OR = 1.45, 95% CI = 1.02-2.07).ConclusionMigraine is an unpleasant sensory and emotional experience associated with psychosocial manifestations that might contribute to the level of suffering of the individuals. Mental pain resulted to be the variable that most differentiated patients with CM from EM.
Transoceanic Arabic historiography: sharing the past of the sixteenth-century western Indian Ocean
Authors: Bahl Christopher D. 
Published: June 2020

AbstractThe early modern western Indian Ocean constituted a dynamic space of human interaction. While scholarship has mostly concentrated on trade and commerce, recent studies have shifted the focus to social and cultural mobilities. This article argues for the emergence of a transoceanic Arabic historiography during the sixteenth century, which reflected on the cultural integration of regions from Egypt, the Hijaz, and Yemen in the Red Sea region, to Gujarat, the Deccan, and Malabar in the subcontinent. Historians from the Persian cosmopolis further north observed a strong cultural connection between Arabophone communities of the western Indian Ocean region. Manuscript collections in India show that Arabic historical texts from the Red Sea region had a readership in the subcontinent. Most importantly, mobile scholars began to compose Arabic histories while receiving patronage at the western Indian courts. Scholarly mobilities fostered cultural exchanges, which increasingly built on a shared history, written, read, and circulated in Arabic during the sixteenth century
Analysis of high-order sub-harmonically injection-locked oscillators
Authors: Hernández Silvia , Pontón Mabel , Sancho Sergio , Suárez Almudena 
Published: June 2020

AbstractHigh-order sub-harmonically injection-locked oscillators have recently been proposed for low phase-noise frequency generation, with carrier-selection capabilities. Though excellent experimental behavior has been demonstrated, the analysis/simulation of these circuits is demanding, due to the high ratio between the oscillation frequency and the frequency of the input source. This work provides an analysis methodology that covers the main aspects of the circuit behavior, including the detection of the locking bands and the prediction of the phase-noise spectral density. Initially, the oscillator in the presence of a multi-harmonic input source is described with a reduced-order envelope-domain formulation, at the oscillation frequency, based on an oscillator-admittance function extracted from harmonic-balance simulations. This allows deriving an expression for the oscillation phase shift with respect to the input source, and the average of this phase shift is shown to evolve continuously in the distinct synchronization bands obtained when varying a tuning voltage. This property can be used to detect the locking bands in circuit-level envelope-domain simulations, which, as shown here, can be done through different Fourier decompositions and sampling rates. The phase noise of the high-order sub-harmonic injection-locked oscillator under an arbitrary periodic input waveform is investigated in detail. The frequency response to the noise sources is described with a semi-analytical formulation, relying on the oscillator-admittance function in injection-locked conditions. The input noise is derived from the timing jitter of the injection source and the phase-noise response is shown to exhibit a low-pass characteristic, which initially follows the up-converted input noise and then the oscillator own noise sources. A method is proposed to identify the key parameters of the derived phase-noise spectrum from envelope-domain simulations. The various analysis methodologies have been applied to a prototype at 2.7 GHz at the sub-harmonic order N = 30 which has been manufactured and measured.
Assessing River Basin Development Given Water‐Energy‐Food‐Environment Interdependencies
Authors: Geressu Robel , Siderius Christian , Harou Julien J. , Kashaigili Japhet , Pettinotti Laetitia , Conway Declan 
Published: June 2020

AbstractMany river basins in the Global South are undergoing rapid development with major implications for the interdependent water‐energy‐food‐environmental (WEFE) “nexus” sectors. A range of views on the extent to which such natural‐human systems should be developed typically exists. The perceived best investments in river basins depend on how one frames the planning problem. Therefore, we propose an approach where the best possible (optimized) implementations of different river basin development scenarios are assessed by comparing their WEFE sector trade‐offs. We apply the approach to Tanzania's Rufiji river basin, an area with multiple WEFE interdependencies and high development potential (irrigation and hydropower) and ecosystem services. Performance indicators are identified through stakeholder consultation and describe WEFE sector response under scenarios of river basin development. Results show considerable potential exists for energy and irrigation expansion. Designs that prioritize energy production adversely affect environmental performance; however, part of the negative impacts can be minimized through release rules designed to replicate the natural variability of flow. The reliability of monthly energy generation is more sensitive to environmental‐oriented management than the cumulative annual energy production. Overall results highlight how sectoral trade‐offs change depending on the extent of development, something that may be difficult to regulate in the future, and that there are important basin‐scale interdependencies. Benefits and limitations of the approach and its application are discussed.
Effects of Semistochastic Westerly Wind Bursts on ENSO Predictability
Authors: Tan Xiaoxiao , Tang Youmin , Lian Tao , Zhang Shouwen , Liu Ting , Chen Dake 
Published: June 2020

AbstractWesterly wind bursts (WWBs) occurring over the tropical Pacific play an important role on El Niño‐Southern Oscillation (ENSO) dynamics. Currently, climate models have significant biases in their representation of WWBs, which may limit their ability to predict ENSO. In this study, we explore the possibility of improving ENSO prediction by introducing a semistochastic WWBs parameterization scheme into the Community Earth System Model (CESM). Three ensemble hindcasts, namely, the control run with the original CESM, the WWB run with parameterized WWBs, and the Non_WWB run with built‐in WWBs removed, are conducted for the period 1982–2016. We find that CESM with parameterized WWBs enables better ENSO prediction, especially for both amplitude and spatial distribution of eastern Pacific and central Pacific El Niño events. This improvement is related to more realistic representation of WWBs which leads to better prediction of surface wind stress anomalies and thermocline depth anomalies.
Directional Characteristic of Wind Stress Vector Under Swell‐Dominated Conditions
Authors: Chen Sheng , Qiao Fangli , Xue Yuhuan , Chen Siyu , Ma Hongyu 
Published: June 2020

AbstractThe wind stress vector over the ocean surface is often misaligned with the wind direction; this misalignment in a swell‐dominated regime is not well investigated. Directional characteristic of the wind stress vector under swell‐dominated conditions is analyzed through direct flux observations taken over the coastal region in the northern South China Sea. Observational Ogive curves demonstrate that an additional velocity component induced by a strong swell at wind speeds below 4 m/s can be captured at a height of 17 m away from the sea surface. Our results show that swell can cause a deviation in the wind stress from the wind direction, and the stress vectors mostly reside between the wind direction and the opposite swell direction under low to moderate wind and strong background swell conditions. Further directional analysis indicates that the deviation in the stress vector from the wind vector is mainly governed by the speeds and directions of the wind and swell. With the increase in the wind speed and inverse wave age, this deviation decreases and becomes less scattered; additionally, it increases with the angle between the wind and swell directions, and a linear relation is proposed at wind speeds greater than 6 m/s.
How promising is phototherapy for cancer?
Authors: Shi Huayun , Sadler Peter J. 
Published: June 2020

SummaryOncological phototherapy, including current photodynamic therapy (PDT), developmental photoactivated chemotherapy (PACT) and photothermal therapy (PTT), shows promising photo-efficacy for superficial and internal tumours. The dual application of light and photochemotherapeutic agents allows accurate cancer targeting, low invasiveness and novel mechanisms of action. Current advances in new light sources and photoactive agents are encouraging for future development.
Stabilization of HIF-1α alleviates osteoarthritis via enhancing mitophagy
Authors: Hu Sunli , Zhang Chunwu , Ni Libin , Huang Chongan , Chen Dingwen , Shi Keqing , Jin Haiming , Zhang Kairui , Li Yao , Xie Ling , Fang Mingqiao , Xiang Guangheng , Wang Xiangyang , Xiao Jian 
Published: June 2020

AbstractMitochondrial dysfunction leads to osteoarthritis (OA) and disc degeneration. Hypoxia inducible factor-1α (HIF-1α) mediated mitophagy has a protective role in several diseases. However, the underlying mechanism of HIF-1α mediated mitophagy in OA remains largely unknown. This current study was performed to determine the effect of HIF-1α mediated mitophagy on OA. Therefore, X-ray and tissue staining including HE staining, safranin O-fast green (S-O) and Alcian Blue were used to assess imageology and histomorphology differences of mouse knee joint. Transcriptional analysis was used to find the possible targets in osteoarthritis. Western blot analysis, RT-qPCR and immunofluorescence staining were used to detect the changes in gene and protein levels in the vitro experiment. The expression of HIF-1α was increased in human and mouse OA cartilage. HIF-1α knockdown by siRNA further impair the hypoxia-induced mitochondrial dysfunction; In contrast, HIF-1α mediated protective role was reinforced by prolylhydroxylase (PHD) inhibitor dimethyloxalylglycine (DMOG). In addition, HIF-1α stabilization could alleviate apoptosis and senescence via mitophagy in chondrocytes under hypoxia condition, which could also ameliorate surgery-induced cartilage degradation in mice OA model. In conclusion, HIF-1α mediated mitophagy could alleviate OA, which may serve as a promising strategy for OA treatment.