bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH EKSTRAK BAWANG PUTIH (Allium sativum) TERHADAP TINGKAT PENCEGAHAN INFEKSI BAKTERI Vibrio harveyi DAN KELULUSHIDUPAN IKAN NILA SALIN (Oreochromis niloticus)
Authors: Simorangkir Raynol , Sarjito Sarjito , Haditomo Alfabetian Harjuno Condro 
Published: December 2020

Vibrio harveyi merupakan salah satu agen pembawa penyakit vibriosis yang menjadi penyebab kematian masal dalam budidaya ikan bersalinitas baik pembenihan maupun pembesaran. Bawang putih (Allium sativum) sebagai salah satu tanaman obat terbukti memiliki aktivitas antibakteri terhadap spektrum luas bakteri Gram positif maupun Gram negatif, sehingga berpotensi dijadikan antibiotik alami. Penelitian ini bertujuan untuk mengkaji pengaruh penambahan ekstrak bawang putih (A. sativum) pada pakan terhadap kelulushidupan ikan nila salin (Oreochromis niloticus) yang diinfeksi oleh bakteri V.harveyi. Penelitian dilakukan dengan metode eksperiman menggunakan Rancangan Acak Lengkap (RAL) dengan 4 perlakuan dan 3 ulangan. Parameter yang diamati yaitu kelulushidupan (survival rate/SR), total leukosit, dan gejala klinis secara morfologi ikan nila salin yang diinfeksi bakteri V.harveyi. Total ikan uji sebanyak 120 ekor dengan panjang rata-rata ± 10 cm. Perlakuan yang diberikan yaitu A (0 ppm), B (50 ppm), C (100 ppm), dan D (150 ppm) didapat berdasarkan hasil uji pendahuluan berupa uji zona hambat. Pergantian air dilakukan setiap 3 kali sehari sebanyak 30% dari air pemeliharaan selama 14 hari. Hasil penelitian menunjukkan bahwa penambahan ekstrak bawang puith berpengaruh nyata terhadap kelulushidupan (p<0,05). Perlakuan D (150 ppm) menunjukkan kelangsungan hidup tertinggi (68,15%), diikuti perlakuan C (66,67%), B (62,96%) dan A (48,15%). Konsentrasi terbaik ditunjukkan oleh perlakuan D yaitu 150 ppm.
EXPLICIT-IMPLICIT DISCREPANCY IN MACRO-LEVEL MENTAL ILLNESS STIGMA IS LINKED TO PREVALENCE AND CARE
Authors: Beltzer Miranda L. , Moulder Robert G. , Starns Abigail L. , Teachman Bethany A. 
Published: December 2020

Introduction: This study explores the associations in the United States between each state's stereotypes about the dangerousness of people with mental illness and important outcomes for people with mental illness.Methods: Implicit association test and questionnaire data from 17,312 online participants were aggregated within states and years. Each state's annual average implicit and explicit stereotypes were used to predict state differences in prevalence, and treatment, unemployment, and homelessness among people with mental illness.Results: Implicit and explicit perceived dangerousness interact such that in states with low explicit perceived dangerousness, implicit perceived dangerousness is positively associated with all outcomes. In states with high explicit perceived dangerousness, implicit perceived dangerousness is negatively associated with homelessness.Discussion: Explicit-implicit discrepancy in macro-level perceived dangerousness is generally associated with worse outcomes for people with mental illness, but the effects are small. Macro-level stereotypes might have larger effects in smaller regions, like counties, than in states.
In memoriam: Doctor Fernando Gilbert Quevedo Ganoza
Authors: Bravo Orellana Gustavo 
Published: December 2020

Agradecerte Maestro por tu ejemplo de vida y probidad.
La que hidalgamente en el fecundo camino de tu vida has llevado con orgullo de hombre honesto y sencillo e inmaculada trayectoria que honran tu buen nombre y el de tu familia.
Agradecerte por tu enseñanzas no solo las del docente presente , siempre preocupado por aprender más y enseñar; sino también por la lecciones de vida, las tuyas y las que con anécdotas sin par nos transmitías a los que nos consideramos tus discípulos y amigos.
Caracterización de las neoplasias caninas diagnosticadas por histopatología en el Laboratorio de Histología y Patología Veterinaria de la Universidad Peruana Cayetano Heredia: periodo 2003-2015
Authors: Aco Alburqueque Renato , Mamani Javier , Grandez Ricardo 
Published: December 2020

El presente estudio tuvo como objetivo caracterizar la frecuencia de neoplasias caninas diagnosticadas por histopatología durante el periodo del 2003 al 2015 en el Laboratorio de Histología y Patología Veterinaria de la Universidad Peruana Cayetano Heredia. Se analizaron un total de 2620 casos, de los cuales solo el 46.3% fueron incluidos en el estudio. El diagnóstico morfológico fue reclasificado de acuerdo con la "Clasificación Histológica Internacional de Tumores de Animales Domésticos" (OMS-AFIP), excluyendo los tumores mamarios que fueron clasificados de acuerdo con Goldschmidt et al. (2011). El sexo, la edad, la raza, la ubicación anatómica de la muestra, las características morfológicas o clínicas y el grado de malignidad se registraron y analizaron mediante análisis estadístico. El Carcinoma de células escamosas fue la neoplasia más frecuente (7.7%), siendo las hembras y los pacientes geriátricos los más afectados (60.7 y 54.4 % respectivamente). La raza cruzada presento mayor prevalencia de neoplasias (35.7%); además, la presencia de tumor fue la presentación clínica más frecuente (93.7%), ubicándose principalmente en el sistema tegumentario (51.2%) y la glándula mamaria (23.6%). El 72,1% de las neoplasias exhibieron características malignas, encontrándose una asociación con la presencia de un proceso inflamatorio. Se requiere una evaluación adicional por medio de inmunoquímica para obtener un diagnóstico preciso.
Los Pre-ALAS y ALAS en América Latina y El Caribe. Entrevista a Marcelo Arnold, Presidente de la Asociación Latinoamericana de Sociología (ALAS)
Authors: Ríos Burga Jaime 
Published: December 2020

Jaime Ríos: Profesor Marcelo Arnold, ¿Qué importancia científica y social tienen hoy para América Latina y El Caribe los Encuentros Pre Alas previo al Congreso de Costa Rica 2015?
Estos encuentros son el legado de una antigua práctica de la Asociación. De hecho, las Asociaciones Nacionales de Sociología, desde los comienzos, se hicieron parte de la Asociación y acoplaron sus propios congresos con las actividades de ALAS. Actualmente, entre otras funciones, los eventos nacionales permiten el re-encuentro de las comunidades de ciencias sociales locales y alinearlas con las temáticas y discusiones previstas para el Congreso Bienal de la Asociación. También, por lo que he podido apreciar, son un espacio para el dialogo intergeneracional, donde jóvenes maestros y sus estudiantes se vinculan con “figuras” internacionales en un contexto de discusión crítica, respetuosa y transparente.
Comentario de la revista ALAS: Controversias y Concurrencias Latinoamercanas
Authors: Ríos Burga Jaime 
Published: December 2020

Mi agradecimiento al Director y los editores de la revista: César Ricardo Siqueira Bolaño, Carlos Arcila Calderón, Eduardo Andrés Sandoval Forero y Alicia Itati Palermo y a todos los que han contribuido con su publicación los miembros de la Asociación Latinoamericana de Investigadores de la Comunicación.
Destacar la labor del Programa Editorial de la Presidencia de ALAS con Marcelo Anold por promover este esfuerzo creativo.
Una visión de conjunto de la Revista nos hace ver su riqueza de contenido. Nos ubica frente a la centralidad de la problemática de los enfoques o teoría o teorías de la colonialidad y su relación con los estudios e investigaciones poscoloniales.
Trends in Epidemiology and Microbiology of Severe Sepsis and Septic Shock in Children
Authors: Sehgal Mukul , Ladd Hugh J. , Totapally Balagangadhar 
Published: December 2020

BACKGROUND AND OBJECTIVES:
To explore the microbiologic etiology and trends in incidence and survival of nonneonatal pediatric sepsis in the United States by using the 2006, 2009, and 2012 Kids’ Inpatient Database.

METHODS:
Children with sepsis were identified by using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes for severe sepsis and septic shock (ICD-9-CM cohort) and by the modified Angus method, which incorporates ICD-9-CM codes for infection and organ dysfunction (Angus cohort). Temporal trends in incidence and microbiologic etiology were evaluated.

RESULTS:
Among 8 830 057 discharges, 26 470 patients in the ICD-9-CM cohort were diagnosed with severe sepsis and septic shock (29.97 per 10 000 discharges) and 89 505 patients in the Angus cohort (101.34 per 10 000 discharges). The incidence of sepsis increased in both cohorts from 2006 to 2012 (P &lt; .01). In the Angus cohort, the case-fatality rate was the highest for methicillin-resistant Staphylococcus aureus (14.42%, P &lt; .01) among Gram-positive organisms and for Pseudomonas (21.49%; odds ratio: 2.58 [95% confidence interval: 1.88–3.54]; P &lt; .01) among Gram-negative organisms.

CONCLUSIONS:
The incidence of sepsis has increased, and the sepsis case-fatality rate has decreased, without a decrease in the overall sepsis-associated mortality rate among hospitalized children. Also, bacterial and fungal organisms associated with the pediatric sepsis have changed over these years. These findings are important for focusing the allocation of health care resources and guiding the direction of future studies.
Exploring the Application of Mathematical Modeling in Solving Mathematical Application Problems in Junior High School
Authors: Huang Jing 
Published: December 2020

<p>The idea of mathematical modeling has an important educational function and has a far-reaching impact on students’ learning and growth. Based on this, this paper studies in detail the application of mathematical modeling thought in the teaching of practical problems in junior middle schools, aiming at improving students’ problem-solving efficiency, cultivating students’ mathematical literacy and continuously improving students’ mathematical learning ability.</p><p> </p>
Towards the institutionalisation of community engagement in higher education in South Africa
Authors: Bhagwan Raisuyah 
Published: December 2020

Although discourse related to the salience of community engagement in higher education has proliferated, little has focussed on the process of institutionalisation of community engagement, in South Africa. This paper presents findings from a national study, which focussed on how community engagement can be institutionalised within higher education institutions locally. A qualitative research approach was used to guide the study and in-depth interviews were conducted with members of executive management, members from the directorate and office of community engagement and academics from six universities nationally. Data revealed that there were eight key factors deserving of consideration, in order to institutionalise community engagement within teaching and research and through student involvement, transforming institutional infrastructure and through community partnerships.
Pengaruh Dukungan Endorser Dan Brand Familiarity Terhadap Perception Of Purchase Risk Dan Dampaknya Pada Niat Beli Produk Brand Extension
Authors: Mayangsari Lialutfi , Rudianto Y. Lilik 
Published: December 2020

At this time, the firms faced tight competition. The firms expected to manage the resources possessed to be able to win the competition. One method used to develop the brand with the expansion of related or unrelated to the parent brand. This strategy is done by utilizing the parent brand advertising campaign media. In the advertising, usually raises the figure endorser such as a celebrityor not to display the endorser with a familiar brand or unfamiliar brand. By looking at the ads with display support different endorser and brands make different consumer response to the perception of risk purchase that ultimately led to purchase intention the product extension.This study was conducted to investigate the effect of endorser support and brand familiarity to perception of purchase risk and its impact on purchase intention of brand extension products. This study tried to see the main effect of the variables and its interactions with the effect that using a factorial experimental design 2 (endorser support) x 2 (brand familiarity) with between subject methods. Data were obtained from 120 respondents who are students of S1 Management Faculty of Economics and Business, University of Airlangga.The analysis showed that there were no significant difference from the endorser support and there are significant differences from the brand familiarity on perception of purchase risk and there is no interaction effect between the endorser support and brand familiarity for reduces the perception of risk perceived by consumers. Perception of risk purchase also significantly influence consumer purchase intentions on the product brand extension.
Analisis Pengaruh Integrative Leadership Terhadap Organizational Justice, Employee Engagement Dan Organizational Citizenship Behavior
Authors: Srimulyani Veronika Agustini 
Published: December 2020

Organizations have long been interested in how employees think and feel his work and what causes employees are willing to dedicate themselves to the organization. The researchers found a variable motivational leadership style that leads to the formation of positive attitudes of the officials who in turn can improve employee job performance. The objective of this research are to study the effect integrative leadership on organizational justice, employee engagement, and organizational citizenship behavior (OCB), with teachers at SMA/SMK/MAN/MAS di kota Madiun as respondents. This research used the quantitative approach with the survey method. The samples of this research were 409 teachers, selected non-randomly. The data were obtained by distributing questionnaires and analyzed by using the descriptive statistics and path analysis in inferential statistics. The results of the research can be concluded that: integrative leadership has a positive significant effect on organizational justice; integrative leadership significant positive effect on employee engagement; integrative leadership significant positive effect on employee engagement on OCB.
IMPLEMENTASI HONEYPOT PADA JARINGAN INTERNET LABOR FAKULTAS TEKNIK UNIKS MENGGUNAKAN DIONAEA SEBAGAI KEAMANAN JARINGAN
Authors: Siregar Muhammad Hasim , Dermawati Rosi 
Published: December 2020

AbstractLack of knowladge of computer user about system security problem is one of the cause of computer problems. There are many computers that do not update their antivirus and some even do not use an antivirus. Network security techniques usually block attacks using a firewall or detect attack with IDS (Intruction Detection System), which is in charge of guarding against axisting attacks. However, by only using IDS the network administrator will be overwhelmed checking every notification given by IDS. This IDS works almost the same as an antivirus, unable to work in an encrypted environment or an IPv6 environment. For that, additional security is needed such as a dionaea honeypot. A honeypot is a fake system the signed to trap attacker, as if it were a real system. Based on these problems, a research will be conducted on the Analysis And Implementation Of Honeypot Using Dionaea as Network Security Support. Keywords: Honeypot, Dionaea, IDS, Firewall, Malware
Conductivity Study of DTAB in Water and Ethanol-Water Mixture in the Presence and Absence of ZnSO4
Authors: Acharya Sangita , Niraula Tulasi , Bhattarai Ajaya 
Published: December 2020

The physicochemical behaviour of dodecyltrimethylammonium bromide (DTAB) in water and ethanol-water mixture in the presence and absence of ZnSO4 were studied by measuring the conductivity at 298.15 K. The pre-micellar (S1) and post-micellar slopes (S2) were obtained and calculated the degree of dissociation (α) and the critical micelle concentration (cmc). With an increase in ethanol content, the cmc and α of DTAB increased whereas, in the presence of ZnSO4, the cmc and α decreased. By using cmc and α, thermodynamic properties as the standard free energy of micellization ( ) were evaluated. With an increase in ethanol content, the negative values of are decreased indicating less spontaneous in the micellization which makes micellization less favourable. The correlation of the pre-micellar and post-micellar slopes with the volume fraction of ethanol were discussed. DTAB micellization was tested in contexts of specific solvent parameters and solvophobic parameter.
Fractional Local Metric Dimension of Comb Product Graphs
Authors: Aisyah Siti , Utoyo Mohammad Imam , Susilowati Liliek 
Published: December 2020

The local resolving neighborhood of a pair of vertices for and is if there is a vertex in a connected graph where the distance from to is not equal to the distance from to , or defined by . A local resolving function of is a real valued function such that for and . The local fractional metric dimension of graph denoted by , defined by In this research, the author discusses about the local fractional metric dimension of comb product are two graphs, namely graph and graph , where graph is a connected graphs and graph is a complate graph and denoted by We get
Real-Time Cloth Simulation on Virtual Human Character Using Enhanced Position Based Dynamic Framework Technique
Authors: Ali Itimad , Mohammed Mazin , Al-Sharify Talib , Kolivand Hoshang 
Published: December 2020

Cloth simulation and animation has been the topic of research since the mid-80's in the field of computer graphics. Enforcing incompressible is very important in real time simulation. Although, there are great achievements in this regard, it still suffers from unnecessary time consumption in certain steps that is common in real time applications. This research develops a real-time cloth simulator for a virtual human character (VHC) with wearable clothing. This research achieves success in cloth simulation on the VHC through enhancing the position-based dynamics (PBD) framework by computing a series of positional constraints which implement constant densities. Also, the self-collision and collision with moving capsules is implemented to achieve realistic behavior cloth modelled on animated characters. This is to enable comparable incompressibility and convergence to raised cosine deformation (RCD) function solvers. On implementation, this research achieves optimized collision between clothes, syncing of the animation with the cloth simulation and setting the properties of the cloth to get the best results possible. Therefore, a real-time cloth simulation, with believable output, on animated VHC is achieved. This research perceives our proposed method can serve as a completion to the game assets clothing pipeline.
Topology GeometRics for the generation of the RoccustyrnaTM molecule, a ligand targeted COVID-19-D614G sites.
Authors: Grigoriadis Ioannis 
Published: December 2020

Abstract
SARS coronavirus 2 (SARS-CoV-2) encoding a D614G mutation in the viral spike (S) protein predominate over time in locales where it is found, implying that this change enhances viral transmission. It has also been observed that retroviruses pseudotyped with SG614 infected ACE2-expressing cells markedly more efficiently than those with SD614. The availability of newer modeling techniques, powerful computational resources, and good-quality data have made it possible to generate reliable predictions for new chemical entities, impurities, chemicals, natural products, and a lot of other substances fuelling further development and growth of the field to balance the trade-off between the molecular complexity and the quality of such predictions that cannot be obtained by any other method. In this article, we effectively use a decision tree to obtain an optimum number of small chemical active chemical features from a collection of thousands of them utilizing a shallow neural network and jointly free energy cumulative feature ranking method with decision tree taking both network parameters and input toxicity benchmark features into account. In this paper, we strongly combine the toxic models and ADMET methods that are simple in machine learning characteristics, efficient in computing resource usage, and powerful to achieve very high accuracy levels for the in-silico generation of the RoccustyrnaTM small molecule, a less toxic nano-ligand targeted the COVID-19-D614G mutation using Topology Euclidean Geometric and Artificial Intelligence-Driven Predictive Neural Networks. To demonstrate this, we also develop a Gravitational Topological (UFs) based Quantum-Parallel Particle Swarm Inspired framework using only 2D chemical features that are less compute- intensive.
Systematic analysis of RNAi-accessible SARS-CoV-2 replication steps identifies ORF1 as promising target
Authors: Ambike Shubhankar , Cheng Cho-Chin , Afridi Suliman , Feuerherd Martin , Hagen Philipp , Grass Vincent , Merkel Olivia , Pichlmair Andreas , Ko Chunkyu , Michler Thomas 
Published: December 2020

Abstract
A promising approach to tackle the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) could be small interfering (si)RNAs. The proof of concept that SARS-CoV-2 can be inhibited with siRNAs, however, is missing. Here, we report that siRNAs can target genomic RNA (gRNA) of SARS-CoV-2 after cell entry, terminating replication before start of transcription and preventing cytopathic effects. Coronaviruses replicate via negative sense intermediate transcripts using a unique discontinuous transcription process. As a result, each viral RNA contains identical sequences at the 5’ and 3’ end. Surprisingly, siRNAs were not active against intermediate negative sense transcripts. Targeting sequences shared by different viral transcripts allowed simultaneous suppression of gRNA and subgenomic (sg)RNAs by a single siRNA. The most effective suppression of viral replication and spread, however, was achieved by siRNAs targeting open reading frame 1 (ORF1) which is solely part of gRNA. We propose two independent mechanisms for this: An increased accessibility of translational-active ORF1 before the start of transcription, as well as highly abundant sgRNAs out-competing siRNAs that target common sequences of transcripts. Our work encourages the development of siRNA-based therapies for COVID-19 and suggests that an early therapy start, together with targeting ORF1, might be key for high antiviral efficacy.
Identification of SRGAP2 as a Potential Oncogene and a Prognostic Biomarker in Hepatocellular Carcinoma Using Bioinformatics Analyses and Biological Experiments
Authors: Li Yan , Qiao Lu , Bai Yuru , Xiao Cailan , Wu Jian , Gao Xiaoliang , Qiao Chenyang , Shi Yongquan , Hou Wei , Wang Jinhai , Xie Ning , Liu Na 
Published: December 2020

Abstract
Background: Hepatocellular carcinoma (HCC) is one of the common malignancies worldwide. Slit-Robo GTPase-activating proteins (SRGAPs) have been shown to regulate the occurrence and development of various tumors. However, their specific role in HCC remains elusive.Methods: The expression pattern, genetic alteration and prognostic value of SRGAPs in HCC are analyzed by bioinformatics tools. The biological functions of SRGAP2 in HCC cells are demonstrated by in vitro experiments. The high-throughput RNA sequencing is conducted to explore the underlying molecular mechanisms of SRGAP2 in HCC cells.Results: The expression levels of SRGAP1 and SRGAP2 are significantly elevated in HCC tissues compared to the normal both in Oncomine and TCGA datasets, and SRGAP2 are dramatically upregulated both in mRNA and protein levels. Moreover, higher SRGAP2 is significantly related to the clinical stages of HCC. Meanwhile, SRGAP2 might be an independent prognostic indicator, as it correlates negatively with the clinical outcomes of HCC patients. Further SRGAP2-silencing experiments imply that SRGAP2 might remarkably promote the migration and invasion of HCC cells in EMT-independent manners. Based on the high-throughput RNA sequencing of SRGAP2-knockdown HCC cells, enrichment and network analyses demonstrate that SRGAP2 is closely associated with cellular metabolic signaling.Conclusions: Our study firstly illustrates the crucial role of SRGAP2 in the metastasis of HCC and explores its underlying molecular mechanisms. We identify SRGAP2 as a promising prognostic biomarker and a novel therapeutic target for HCC patients.