bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19: relationship between atmospheric temperature and daily new cases growth rate
Authors: Rouen A. , Adda J. , Roy O. , Rogers E. , Lévy P. 
Published: August 2020

AbstractPurpose: The novel coronavirus (severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)) first appeared in Wuhan, China, in December 2019, and rapidly spread across the globe. Since most respiratory viruses are known to show a seasonal pattern of infection, it has been hypothesised that SARS-CoV-2 may be seasonally dependent as well. The present study looks at a possible effect of atmospheric temperature, which is one of the suspected factors influencing seasonality, on the evolution of the pandemic. Basic procedures: Since confirming a seasonal pattern would take several more months of observation, we conducted an innovative day-to-day micro-correlation analysis of nine outbreak locations, across four continents and both hemispheres, in order to examine a possible relationship between atmospheric temperature (used as a proxy for seasonality) and outbreak progression. Main findings: There was a negative correlation between atmospheric temperature variations and daily new cases growth rates, in all nine outbreaks, with a median lag of 10 days. Principal conclusions: The results presented here suggest that high temperatures might dampen SARS-CoV-2 propagation, while lower temperatures might increase its transmission. Our hypothesis is that this could support a potential effect of atmospheric temperature on coronavirus disease progression, and potentially a seasonal pattern for this virus, with a peak in the cold season and rarer occurrences in the summer. This could guide government policy in both the Northern and Southern hemispheres for the months to come.
Antral follicular count and its relationship with ovarian volume, preantral follicle population and survival, oocyte meiotic progression and ultrastructure of in vitro matured bovine cumulus–oocyte complexes
Authors: de Vasconcelos Gisvani Lopes , Maculan Renata , da Cunha Ellen Vasconcelos , Silva Anderson Weiny Barbalho , Batista Ana Liza Souza , Donato Mariana Aragão Matos , Peixoto Christina Alves , Silva José Roberto Viana , de Souza José Camisão 
Published: August 2020

SummaryThis study aimed to evaluate the relationship between antral follicular count (AFC) and ovarian volume (OV), preantral follicular population and survival, meiotic progression and ultrastructure of cumulus–oocyte complexes (COCs) after in vitro maturation. In experiment 1, the relationship between AFC and preantral follicle population and survival was evaluated by classical histology. In experiment 2, the relationship among AFC, OV, ability of oocytes to resume meiosis and ultrastructure of in vitro matured bovine COCs was studied. A positive correlation (P < 0.05) between AFC and the numbers of healthy primordial, degenerate and total follicles was observed, as well as with healthy secondary follicles and total follicles. The numbers of grades I and II oocytes in ovaries of high AFC class were higher compared with those with intermediate or lower AFC. After in vitro maturation, COCs from ovaries of high AFC had a higher percentage of oocytes in metaphase II compared with those of intermediate and low AFC (P < 0.0001). Ovaries of intermediate AFC had a higher percentage of oocytes in metaphase II compared with ovaries with low AFC (P < 0.0001). The proportion of oocytes in metaphase I, telophase I and anaphase I in COCs from ovaries of intermediate AFC (26.04%) was higher (P < 0.05) compared with that seen in COCs of ovaries with high (8.55%) and low (14.15%) AFC. No differences in the ultrastructure of oocytes were seen. In conclusion, after in vitro maturation, cow ovaries with high AFC have higher numbers of oocytes that reach in metaphase II (MII), but they also have higher numbers of degenerated primordial and primary follicles.
Emotion Recognition and Traffic-Related Risk-Taking Behavior in Patients with Neurodegenerative Diseases
Authors: van den Berg Nils S. , Reesink Fransje E. , de Haan Edward H.F. , Kremer Hubertus P.H. , Spikman Jacoba M. , Huitema Rients B. 
Published: August 2020

AbstractObjectives:Neurodegenerative diseases (NDDs), such as Alzheimer’s disease, frontotemporal dementia, dementia with Lewy bodies, and Huntington’s disease, inevitably lead to impairments in higher-order cognitive functions, including the perception of emotional cues and decision-making behavior. Such impairments are likely to cause risky daily life behavior, for instance, in traffic. Impaired recognition of emotional expressions, such as fear, is considered a marker of impaired experience of emotions. Lower fear experience can, in turn, be related to risk-taking behavior. The aim of our study was to investigate whether impaired emotion recognition in patients with NDD is indeed related to unsafe decision-making in risky everyday life situations, which has not been investigated yet.Methods:Fifty-one patients with an NDD were included. Emotion recognition was measured with the Facial Expressions of Emotions: Stimuli and Test (FEEST). Risk-taking behavior was measured with driving simulator scenarios and the Action Selection Test (AST). Data from matched healthy controls were used: FEEST (n= 182), AST (n= 36), and driving simulator (n= 18).Results:Compared to healthy controls, patients showed significantly worse emotion recognition, particularly of anger, disgust, fear, and sadness. Furthermore, patients took significantly more risks in the driving simulator rides and the AST. Only poor recognition of fear was related to a higher amount of risky decisions in situations involving a direct danger.Conclusions:To determine whether patients with an NDD are still fit to drive, it is crucial to assess their ability to make safe decisions. Measuring emotion recognition may be a valuable contribution to this judgment.
“WE’RE JUST SEPARATE FROM EVERYBODY”
Authors: Leo Aaron 
Published: August 2020

AbstractRecent scholarly work has explored the experiences of racialization among Muslim immigrants in the United States. Such work has challenged a static view of race strictly tied to phenotype by highlighting the significance of culture and religion to racial ascription as well as the varied ways individuals respond to their own racialized position. While valuable, much of this scholarship has analyzed the racialization of Muslim immigrants as it relates to Whiteness thereby neglecting their relationship with other racialized minorities such as African Americans. Moreover, such work has focused on culture and religion without discussing the role that social class plays in the process of racialization. This article seeks to address these gaps by drawing on ethnographic data gathered among a group of Muslim newcomer youth in an urban, multiracial high school in upstate New York. The findings presented here show how these youth are racialized along cultural and religious lines yet actively respond to this process in various ways. In addition, participants articulated racializing comments towards African Americans with significant class connotations. Despite the tensions between Muslim newcomers and African Americans, moments of solidarity were evident and drew attention to the potential for establishing cross-racial alliances.
RING THE ALARM
Authors: Clark Jelisa S. 
Published: August 2020

AbstractIn this research, I use theories of framing and social construction to investigate how race and gender are featured in national news coverage of the school-to-prison pipeline, and how policies and practices funnel students from school to the criminal justice system. Results indicate that there are three primary narratives surrounding the school-to-prison pipeline. The first is a narrative that harsh disciplinary practices in schools are irrational and negatively impact all students. The second narrative crafts the school-to-prison pipeline as a social problem for all Black students irrespective of gender. The final narrative emphasizes the impact of exclusionary discipline on Black boys. Each of these narratives functions to erase the experiences of Black girls. Ultimately, I argue that we need to take a more intersectional approach to school discipline policies and take into account how Black women and girls are situated within popular and policy discussions.
Linguistic Assimilation Does Not Reduce Discrimination Against Immigrants: Evidence from Germany
Authors: Choi Donghyun Danny , Poertner Mathias , Sambanis Nicholas 
Published: August 2020

AbstractMany western liberal democracies have witnessed increased discrimination against immigrants and opposition to multiculturalism. Prior research identifies ethno-linguistic differences between immigrant and native populations as the key source of such bias. Linguistic assimilation has therefore been proposed as an important mechanism to reduce discrimination and mitigate conflict between natives and immigrants. Using large-scale field experiments conducted in 30 cities across Germany – a country with a high influx of immigrants and refugees – we empirically test whether linguistic assimilation reduces discrimination against Muslim immigrants in everyday social interactions. We find that it does not; Muslim immigrants are no less likely to be discriminated against even if they appear to be linguistically assimilated. However, we also find that ethno-linguistic differences alone do not cause bias among natives in a country with a large immigrant population and state policies that encourage multiculturalism.
Compassionate use of JAK1/2 inhibitor ruxolitinib for severe COVID-19: a prospective observational study
Authors: Vannucchi Alessandro M. , Sordi Benedetta , Morettini Alessandro , Nozzoli Carlo , Poggesi Loredana , Pieralli Filippo , Bartoloni Alessandro , Atanasio Alessandro , Miselli Filippo , Paoli Chiara , Loscocco Giuseppe G. , Fanelli Andrea , Para Ombretta , Berni Andrea , Tassinari Irene , Zammarchi Lorenzo , Maggi Laura , Mazzoni Alessio , Scotti Valentina , Falchetti Giorgia , Malandrino Danilo , Luise Fabio , Millotti Giovanni , Bencini Sara , Capone Manuela , Piccinni Marie Pierre , Annunziato Francesco , Guglielmelli Paola ,   for the RUXO-COVID Study Group, Mannelli Francesco , Coltro Giacomo , Fantoni Duccio , Borella Miriam , Ravenda Enrica , Peruzzi Benedetta , Caporale Roberto , Cosmi Lorenzo , Liotta Francesco , Lombardelli Letizia , Logiodice Federica , Vanni Anna , Salvati Lorenzo , Lazzeri Chiara , Bonizzoli Manuela , Peris Adriano , Cianchi Giovanni , Bosi Alberto , Pucatti Michela , Fontanari Paolo , Benemei Silvia , Matucci Cerinic Marco , Turco Lucia 
Published: August 2020

AbstractOverwhelming inflammatory reactions contribute to respiratory distress in patients with COVID-19. Ruxolitinib is a JAK1/JAK2 inhibitor with potent anti-inflammatory properties. We report on a prospective, observational study in 34 patients with COVID-19 who received ruxolitinib on a compassionate-use protocol. Patients had severe pulmonary disease defined by pulmonary infiltrates on imaging and an oxygen saturation ≤ 93% in air and/or PaO2/FiO2 ratio ≤ 300 mmHg. Median age was 80.5 years, and 85.3% had ≥ 2 comorbidities. Median exposure time to ruxolitinib was 13 days, median dose intensity was 20 mg/day. Overall survival by day 28 was 94.1%. Cumulative incidence of clinical improvement of ≥2 points in the ordinal scale was 82.4% (95% confidence interval, 71–93). Clinical improvement was not affected by low-flow versus high-flow oxygen support but was less frequent in patients with PaO2/FiO2 < 200 mmHg. The most frequent adverse events were anemia, urinary tract infections, and thrombocytopenia. Improvement of inflammatory cytokine profile and activated lymphocyte subsets was observed at day 14. In this prospective cohort of aged and high-risk comorbidity patients with severe COVID-19, compassionate-use ruxolitinib was safe and was associated with improvement of pulmonary function and discharge home in 85.3%. Controlled clinical trials are necessary to establish efficacy of ruxolitinib in COVID-19.
Direct observation of photonic Landau levels and helical edge states in strained honeycomb lattices
Authors: Jamadi Omar , Rozas Elena , Salerno Grazia , Milićević Marijana , Ozawa Tomoki , Sagnes Isabelle , Lemaître Aristide , Le Gratiet Luc , Harouri Abdelmounaim , Carusotto Iacopo , Bloch Jacqueline , Amo Alberto 
Published: August 2020

AbstractWe report the realization of a synthetic magnetic field for photons and polaritons in a honeycomb lattice of coupled semiconductor micropillars. A strong synthetic field is induced in both the s and p orbital bands by engineering a uniaxial hopping gradient in the lattice, giving rise to the formation of Landau levels at the Dirac points. We provide direct evidence of the sublattice symmetry breaking of the lowest-order Landau level wavefunction, a distinctive feature of synthetic magnetic fields. Our realization implements helical edge states in the gap between n = 0 and n = ±1 Landau levels, experimentally demonstrating a novel way of engineering propagating edge states in photonic lattices. In light of recent advances in the enhancement of polariton–polariton nonlinearities, the Landau levels reported here are promising for the study of the interplay between pseudomagnetism and interactions in a photonic system.
Lensless light-field imaging through diffuser encoding
Authors: Cai Zewei , Chen Jiawei , Pedrini Giancarlo , Osten Wolfgang , Liu Xiaoli , Peng Xiang 
Published: August 2020

AbstractMicrolens array-based light-field imaging has been one of the most commonly used and effective technologies to record high-dimensional optical signals for developing various potential high-performance applications in many fields. However, the use of a microlens array generally suffers from an intrinsic trade-off between the spatial and angular resolutions. In this paper, we concentrate on exploiting a diffuser to explore a novel modality for light-field imaging. We demonstrate that the diffuser can efficiently angularly couple incident light rays into a detected image without needing any lens. To characterize and analyse this phenomenon, we establish a diffuser-encoding light-field transmission model, in which four-dimensional light fields are mapped into two-dimensional images via a transmission matrix describing the light propagation through the diffuser. Correspondingly, a calibration strategy is designed to flexibly determine the transmission matrix, so that light rays can be computationally decoupled from a detected image with adjustable spatio-angular resolutions, which are unshackled from the resolution limitation of the sensor. The proof-of-concept approach indicates the possibility of using scattering media for lensless four-dimensional light-field recording and processing, not just for two- or three-dimensional imaging.
Trophic cooperation promotes bacterial survival of Staphylococcus aureus and Pseudomonas aeruginosa
Authors: Camus Laura , Briaud Paul , Bastien Sylvère , Elsen Sylvie , Doléans-Jordheim Anne , Vandenesch François , Moreau Karen 
Published: August 2020

Abstract
In the context of infection, Pseudomonas aeruginosa and Staphylococcus aureus are frequently co-isolated, particularly in cystic fibrosis (CF) patients. Within lungs, the two pathogens exhibit a range of competitive and coexisting interactions. In the present study, we explored the impact of S. aureus on the physiology of P. aeruginosa in the context of coexistence. Transcriptomic analyses showed that S. aureus significantly and specifically affects the expression of numerous genes involved in P. aeruginosa carbon and amino acid metabolism. In particular, 65% of the strains presented considerable overexpression of the genes involved in the acetoin catabolic (aco) pathway. We demonstrated that acetoin is (i) produced by clinical S. aureus strains, (ii) detected in sputa from CF patients and (iii) involved in P. aeruginosa’s aco system induction. Furthermore, acetoin is catabolized by P. aeruginosa, a metabolic process that improves the survival of both pathogens by providing a new carbon source for P. aeruginosa and avoiding the toxic accumulation of acetoin on S. aureus. Due to its beneficial effects on both bacteria, acetoin catabolism could testify to the establishment of trophic cooperation between S. aureus and P. aeruginosa in the CF lung environment, thus promoting their persistence.
Suspended scattering particles in motion using OCT angiography in branch retinal vein occlusion disease cases with cystoid macular edema
Authors: Choi Kwang-Eon , Han Sangheon , Yun Cheolmin , Kim Seong-Woo , Oh Jaeryung 
Published: August 2020

AbstractWe aimed to investigate the clinical implication of suspended scattering particles in motion (SSPiM) using optical coherence tomography angiography (OCTA) among branch retinal vein occlusion disease (BRVO) cases with macular edema (ME). Medical records of BRVO patients were reviewed. Central retinal thickness (CRT), ME type, and cyst size on optical coherence tomography images were evaluated before and after intravitreal bevacizumab injection. Nonperfusion area, SSPiM, and microvascular abnormalities in OCTA images were evaluated using a Heidelberg machine. SSPiM was identified in 24 of 56 cases. There were no differences in baseline characteristics between groups with and without SSPiM. Disease duration, disease-free duration, previous injection number, microaneurysms in the superficial vascular complex, and microaneurysms in the deep vascular complex (DVC) (p = 0.003, 0.013, 0.028, 0.003, < 0.001, respectively) differed significantly between the two groups. After multivariate logistic analysis, microaneurysms in the DVC were the only different factor between the two groups (odds ratio [OR]: 0.091; p = 0.001). Furthermore, SSPiM in the DVC (OR 10.908; p = 0.002) and nonperfusion grade (OR 0.039; p < 0.001) were significantly associated with cyst response after intravitreal injection. SSPiM may be correlated with microaneurysms in the DVC and a poor anatomical response after intravitreal injection.
Comparisons of sampling methods for assessing intra- and inter-accession genetic diversity in three rice species using genotyping by sequencing
Authors: Gouda Arnaud Comlan , Ndjiondjop Marie Noelle , Djedatin Gustave L. , Warburton Marilyn L. , Goungoulou Alphonse , Kpeki Sèdjro Bienvenu , N’Diaye Amidou , Semagn Kassa 
Published: August 2020

AbstractTo minimize the cost of sample preparation and genotyping, most genebank genomics studies in self-pollinating species are conducted on a single individual to represent an accession, which may be heterogeneous with larger than expected intra-accession genetic variation. Here, we compared various population genetics parameters among six DNA (leaf) sampling methods on 90 accessions representing a wild species (O. barthii), cultivated and landraces (O. glaberrima, O. sativa), and improved varieties derived through interspecific hybridizations. A total of 1,527 DNA samples were genotyped with 46,818 polymorphic single nucleotide polymorphisms (SNPs) using DArTseq. Various statistical analyses were performed on eleven datasets corresponding to 5 plants per accession individually and in a bulk (two sets), 10 plants individually and in a bulk (two sets), all 15 plants individually (one set), and a randomly sampled individual repeated six times (six sets). Overall, we arrived at broadly similar conclusions across 11 datasets in terms of SNP polymorphism, heterozygosity/heterogeneity, diversity indices, concordance among genetic dissimilarity matrices, population structure, and genetic differentiation; there were, however, a few discrepancies between some pairs of datasets. Detailed results of each sampling method, the concordance in their outputs, and the technical and cost implications of each method were discussed.
Hedgehog-GLI signalling promotes chemoresistance through the regulation of ABC transporters in colorectal cancer cells
Authors: Po Agnese , Citarella Anna , Catanzaro Giuseppina , Besharat Zein Mersini , Trocchianesi Sofia , Gianno Francesca , Sabato Claudia , Moretti Marta , De Smaele Enrico , Vacca Alessandra , Fiori Micol Eleonora , Ferretti Elisabetta 
Published: August 2020

AbstractColorectal cancer (CRC) is a leading cause of cancer death. Chemoresistance is a pivotal feature of cancer cells leading to treatment failure and ATP-binding cassette (ABC) transporters are responsible for the efflux of several molecules, including anticancer drugs. The Hedgehog-GLI (HH-GLI) pathway is a major signalling in CRC, however its role in chemoresistance has not been fully elucidated. Here we show that the HH-GLI pathway favours resistance to 5-fluorouracil and Oxaliplatin in CRC cells. We identified potential GLI1 binding sites in the promoter region of six ABC transporters, namely ABCA2, ABCB1, ABCB4, ABCB7, ABCC2 and ABCG1. Next, we investigated the binding of GLI1 using chromatin immunoprecipitation experiments and we demonstrate that GLI1 transcriptionally regulates the identified ABC transporters. We show that chemoresistant cells express high levels of GLI1 and of the ABC transporters and that GLI1 inhibition disrupts the transporters up-regulation. Moreover, we report that human CRC tumours express high levels of the ABCG1 transporter and that its expression correlates with worse patients’ prognosis. This study identifies a new mechanism where HH-GLI signalling regulates CRC chemoresistance features. Our results indicate that the inhibition of Gli1 regulates the ABC transporters expression and therefore should be considered as a therapeutic option in chemoresistant patients.
Emerging predictors of femoral artery occlusion after pediatric cardiac catheterization
Authors: Kou Lei , Wang Qian , Long Whitney Annie , Tang Feng , Li Lei 
Published: August 2020

AbstractThe Objective was to review the prevalence of femoral artery occlusion (FAO) after cardiac catheterization in children up to 12 years old from two centers in China and identify its related risk factors. After collecting clinical data from patients who had undergone pediatric cardiac catheterization, univariate and multivariate analysis were used to evaluate the correlations between FAO and clinical factors, including sex, age, height, weight, sheath size, operation time, therapeutic strategy, sheath/age, sheath/height and sheath/weight. The ROC curve was also used to assess the influence of risk factors to predict FAO. FAO occurred in 19 (0.9%) out of 2,084 children following cardiac catheterization. Patients with younger age, lower height, longer operation time, electrophysiological (EP) diagnosis or/and therapy for arrhythmias, higher Sheath/Age, higher Sheath/Height and higher Sheath/Weight ratios had higher risk for FAO compared to their respective control groups (p < 0.05). In the multivariate analysis, sheath/age and operation time were independent risk factors for FAO. Patients with operation time > 77.5 min or sheath/age > 0.5334 had a significantly higher risk for FAO. Operation time and sheath/age were confirmed as significant and independent risk factors associated with FAO. Operation time > 77.5 min and sheath/age > 0.5334 could effectively predict high risk of FAO after pediatric cardiac catheterization.