bluuebunny/crossref_metadata_2025_split huggingface dataset:
TREATMENT OF PATIENTS WITH PANCREATIC NEUROENDOCRINE TUMOURS DEPENDING ON THE DIFFERENTIATION GRADE
Authors: Isyangulova A. Z. , Khasanov R. Sh. , Enikeev R. F. , Gordiev M. G. 
Published: November 2019

The incidence of neuroendocrine tumors has significantly increased over the last years.The purpose of the study was to analyze treatment outcomes in patients with pancreatic endocrine tumors (PETs) with regard to histopathologic diagnosis.Material and Methods. The clinical records of 1077 patients with pancreatic tumors were retrospectively analyzed. Fifty patients were diagnosed with PET. Treatment outcomes were assessed with regard to tumor differentiation grade, tumor stage, extent of surgery and drug therapy.Results. The most common histological grade was G1. Patients with G1 tumors had the best 1-and 3-year survival rates regardless of tumor stage. Factors influencing prognosis in patients with PETs were: radical surgery, Ki67 expression level, histological grade (G1–3), tumor stage at diagnosis.
RETROPERITONEAL NON-ORGAN LIPOSARCOMAS: THE MODERN CONCEPT
Authors: Volkov A. Yu. , Nered S. N. , Lyubchenko L. N. 
Published: November 2019

Objective:to conduct a systematic literature review of the published studies on retroperitoneal non-organ liposarcomas.Material and Methods.A literature search was performed using Pubmed, Elibrary, COSMIC databases. The data of retrospective and prospective clinical trials were analyzed. Results. The article reviews contemporary data on epidemiology, classification, clinicalmorphological and molecular-genetic characteristics, as well as diagnosis and treatment of retroperitoneal non-organ liposarcomas. Conclusion. Retroperitoneal sarcomas account for about 13 % of all types of soft tissue sarcomas. Liposarcoma is the most common retroperitoneal mesenchymal tumor. Diagnosis and treatment of non-organ retroperitoneal liposarcoma remain challenging due to poor long-term treatment outcomes. As experience is gained with the diagnosis and treatment of retroperitoneal nonorganic liposarcomas, changes occur in the system of understanding the problem that determines the strategy for providing medical care in this category of patients. The article presents modern concept of retroperitoneal non-organ liposarcomas.
In Search of Architectural Form – Identification of Place. Design of a City Bench in Students’s Projects (Works)
Authors: RACZYŃSKA-MĄKOWSKA Ewa , FAJTANOWSKI Romuald 
Published: November 2019

Abstract
Identification of a PLACE through conscious application of given forms correlated with spatial conditions is a demanding task for a designer who needs to take into consideration the context and history of the space they are supposed to function within. The authors of this study have presented four application examples for a city bench as a form interacting with a selected space in Bydgoszcz (350-thousand inhabitants, a town in the north-west Poland, situated at the confluence of two rivers The Vistula, Brda and Bydgoszcz Canal). The research results allow to identify the main models to be used for defining a PLACE through selection of the form.
Health-Affirming Everyday Landscapes in Sustainable City. Eco-Neighborhoods in France Case
Authors: TROJANOWSKA Monika , SAS-BOJARSKA Aleksandra 
Published: November 2019

Abstract
This paper discusses the close relationship between the concept of health-affirming everyday landscapes and the idea of sustainable city design. The French National program of eco-neighborhood certification ÉcoQuartier is described and the correlation between the concepts of health-affirming landscapes, sustainable cities, and eco-neighborhoods is explained using the example of a selected eco-neighborhood in France.
Properties of Coarse Mineral Aggregates Against Properties of Concrete
Authors: PIASTA Wojciech , BUDZYŃSKI Waldemar , GÓRA Jacek 
Published: November 2019

Abstract
The paper concerns the effect of coarse aggregate type on the strength and strain properties of concrete under instantaneous loading. The studies deal with properties of the crushed aggregates and their effect on the basic mechanical properties and instant deformability of concretes in comparison to gravel concrete. The paper presents test results of mineral composition, crushing strength, absorption by weight, content of irregular grains and mineral dust as well as bulk and specific density of the 5 coarse aggregates: basalt, granite, dolomite, quartzite and natural aggregate (gravel) derived from the Polish rock beds. Strength and strain properties of concretes under compressive instantaneous loading were analyzed. The analysis showed that strength properties and modules of elasticity of tested concretes are proportional to crushing strength of aggregates. Based on the test results of strains it was concluded that the effect of coarse aggregate type on the modulus of elasticity and the limit strain is more significant than that of concrete strength.
Thermal Improvement in Residential Buildings in View of the Indoor Air Quality – Case Study for Polish Dwelling
Authors: BLASZCZOK Monika , BARANOWSKI Andrzej 
Published: November 2019

Abstract
The widespread thermal improvement in residential buildings involves not only the insulation of outdoor walls but also window replacement. In Poland it is the residents of individual premises who manage the replacement and in order to keep their heating bills low, they seek airtight solutions to minimize the cooling of premises due to air infiltration. In this situation the indoor air quality is not considered at all and no exchange of used air and fresh air occurs. Unawareness on the part of residents and the increased costs of replacing the windows which need additional devices to ensure the inflow of air are the main reason for the deteriorating microclimate conditions in residential dwellings.
The present paper demonstrates the measurement of indoor air quality, the building leakage test and the measurement of air flow in exhaust opening a four-bedroom dwelling located in Gliwice, Poland. In order to evaluate the air exchange within a longer period and in different outdoor climate conditions, the measurements were supplemented with numerical simulation of ventilating airflows. Modifications to improve the indoor air quality in the examined flat were also suggested.
The Reuse of Washings from Pool Filtration Plants After the use of Simple Purification Processes
Authors: WYCZARSKA-KOKOT Joanna , LEMPART Anna 
Published: November 2019

Abstract
The main purpose of the research is to show the possibility of using washings after applying simple processes and devices. It is being considered whether they may be drained to watercourses, to the ground, used for watering plants, sprinkling tennis courts and playing fields, flushing toilets or recycled into pool systems. The research concept consisted of comparing the results of physico-chemical analysis of washings samples with the limit values for pollutants in wastewater discharged to water and ground. The research was carried out for 20 pool water treatment plants. It has been shown that the concentration of TSS (total suspended solids) and free chlorine in washings are the main parameters preventing their drainage to the natural environment. The processes of sedimentation or sedimentation assisted by coagulation allow to reduce the TSS concentration below the limit value and leaving the washings to stand for up to several hours or subjecting them to a few minutes of aeration decreases the concentration of free chlorine to an acceptable level. The obtained research results allow to assume that the management of washings in all tested swimming pools would be possible after applying a settler or a settling tank with a coagulant chamber and then a chamber for aeration.
Prediction of sediment concentration based on the MEEMD-ARIMA model in the lower Yellow River
Authors: Zhang Xianqi , Liu Fei , Song Chao , Wu Xiaoyan 
Published: November 2019

Abstract
There are many factors influencing the evolution of sediment concentration, and it is difficult to determine and extract, which brings great difficulties to the high-precision prediction of sediment concentration. Accurate prediction of annual sediment concentration in the lower Yellow River can provide a theoretical basis for flood control and disaster reduction and rational utilization of water and soil resources in the lower Yellow River. For the defects of pseudo-components in data decomposition of Complementary EEMD, the Modified EEMD (MEEMD) method proposed in this paper has the advantage of eliminating pseudo components of IMF and reducing non-stationarity of sediment bearing sequences. Then, combined with the Autoregressive Integrated Moving Average (ARIMA) model with strong approximation ability to the stationary sequence, the MEEMD-ARIMA model for predicting the annual sediment concentration in the lower Yellow River was constructed. Through fitting and predicting the annual sediment concentration in Gaocun Station, it is shown that the model not only considers the evolution of sediment concentration in various frequency domains, but also solves the problem that the ARIMA model requires sequence to be stable, the relative error of prediction is within ±6%, and the prediction accuracy is high, thus providing a new method for the prediction of sediment concentration.
High Expression of miR-206 Predicts Adverse Outcomes: A Potential Therapeutic Target for Esophageal Cancer
Authors: Du Guobo , Zhou Jing , Cheng Long , Ma Xiaojie , Gui Yan , Tan Bangxian 
Published: November 2019

Background:
MicroRNA-206 (miR-206) inhibits cell proliferation, invasion and
migration in a variety of tumors, but the prognostic value of its Esophageal Cancer (EC) remains
unclear.

Objective:
To study the role of miR-206 in EC.

Methods:
The datasets of RNA-Seq, miRNA-Seq, methylation, copy number variation (CNV), and
clinical follow-up information were download from The Cancer Genome Atlas (TCGA). After
integration and standardization, the prognostic value and potential function of miR-206 were
analyzed. The important roles of miR-206 expression in EC genetic and epigenetic mechanisms
were analyzed by RNA-Seq, miRNA-Seq, and methylation data. The potential mechanism of CNV
in different miR-206 expression groups was analyzed using GISTIC.

Results:
High expression of miR-206 was associated with poor outcome of EC (OS: p=0.005,
AUC=0.69, N=178). Transforming growth factor β (TGF-β) signaling pathway, Wnt signaling
pathway, mitogen-activated protein kinases (MAPK) signaling pathway, mammalian target of
rapamycin (mTOR) signaling pathway were inhibited in high expression group. the aberrant
methylation sites in the high and low expression groups were mainly distributed in the promoter
region containing CpG islands, and there were different copy number patterns in the H and L
samples, and the genes in the differential copy number were mainly enriched in cancer-related
pathways, such as thyroid cancer, central carbon metabolism.

Conclusion:
This study explored the unique genomic and epigenetic landscape associated with the
expression of miR-206, provided evidence of mir-206 as a prognostic biomarker or a potential
therapeutic target for EC patients.
Techniques to Overcome Difficulty in Device Deliverability to Lesion in Complex PCI
Authors: Chawla Raman , Ahamad Wasim , Sharma Vivek 
Published: November 2019

:Percutaneous Coronary Intervention (PCI) has revolutionized the management of Coronary Artery Disease and has become the preferred modality of revascularization in a majority of cases. Nevertheless, situations are encountered frequently where device deliverability to coronary lesions entails technical difficulties due to varied anatomies and lesional complexities like tortuosity, calcifications, length of lesions and vessel morphology. While continuous technological refinements are occurring in PCI hardware armamentarium and stent designs, a number of techniques and their modifications and variations have evolved to increase the applicability of PCI to difficult lesions.:The present article envisages a thorough review of all aspects of improving successful device deliverability in complex PCI with prominent emphasis on increasing the backup support of Guide Catheters which is the primary factor of success in difficult coronary lesions.
Metabolomics in Lipoid Proteinosis
Authors: Gonel Ataman , Koyuncu Ismail , Aksoy Mustafa , Celik Hakim 
Published: November 2019

Background:
Lipoid proteinosis (LP) is an autosomal recessive transfer lysosomal
storage disease that is characterized by the accumulation of hyalin substance in the mucous
membranes, skin, internal organs, and brain. Thus far, no biochemical diagnostic
method has been identified.

Objective:
The aim of this study was to determine the carnitine and acylcarnitine metabolic
profiles of LP patients and to examine the potential of LC-MS/MS as a new biochemical
method for the identification of biochemical markers.

Methods:
In this study, 27 carnitine and acylcarnitine esters were measured with LCMS/
MS in serum samples taken from 14 healthy control subjects and 14 patients. The patients,
who presented at the Skin and Venereal Diseases Polyclinic, were diagnosed with LP
on the basis of clinical, radiological, and histopathological examinations.

Results:
The results of the study showed that the C0 (free carnitine) C3, C4, C4:DC, C5DC,
C6, C8, C14:1, C14:2, C16, and C18 acylcarnitines were statistically significantly reduced in
the LP patients (p < 0.05, p < 0.01).

Conclusion:
It was concluded that the application of carnitine profile screening, an inexpensive,
rapid, and reliable method, as a supporting laboratory test could make a contribution to
the differential diagnosis for individuals with suspected LP.
Validasi Modul Pelatihan Disiplin Positif untuk Meningkatkan Praktik Pengasuhan pada Ibu Anak Prasekolah
Authors: Retnaningsih Wijayanti , Setiyawati Diana 
Published: November 2019

This study aimed to validate Positive Discipline Training Module to improve parenting practice. Module validation is conducted through two stages. The first is of content validation which consisted of: 1) validation of contents on materials, methods, media, activities, worksheets, and time used in module, 2) validation of contents about legibility of module for family planning counselors) and two functional validation stages: 1) training of trainer (ToT) for family planning counselors and 2) training of Positive Discipline in mothers of preschool children. The result of the first stage content validity coefficient ranged between 0.750-0.958. The result of the second stage content validity ranged between 0.70-0.95. The result of ToT indicated that it could improve positive discipline knowledge on family planning counselors (Z = -2.032, p = 0.042). Mann Whitney U test showed that Positive Discipline Training could improve the practice of parenting in the experimental group (U = 0.000, p < 0.01). Thus, the module had sufficient content and functional validity. This research concluded that Positive Discipline Training Module is valid for improving parenting practice for mothers of the preschool children with family planning counselor trainers.
Ossuaries and Charnel Houses: Death, Resurrection and the Living
Authors: Tradii Laura 
Published: November 2019

During my studies on the connections between Black Death and culture during the Renaissance, I have come across more than once with a less known aspect of Renaissance Europe which has particularly attracted my attention. I am speaking about the concept/place of “ossuary”, a room or set of rooms containing hundreds of human bones (often arranged in the most peculiar forms) gradually becoming places of cult charged with symbolic meaning. In this brief article, I would like to illustrate the ways in which ossuaries reflect conceptions of death and resurrection through two relevant examples.
Alimentação e mídia: uma revisão teórica sob a luz da teoria da midiatização
Authors: Llano Linares Nicolás 
Published: November 2019

Este artigo visa articular um panorama sobre pesquisas recentes desenvolvidas no campo da comunicação e dos estudos midiáticos que tem as culturas alimentares como principal objeto de pesquisa. A partir de uma discussão inicial sobre o papel da alimentação como objeto de estudo nos campos supramencionados, apresentamos uma leitura crítica da literatura acadêmica que explora as transformações nas culturas alimentares promovidas pelo chamado processo de midiatização da cultura e sociedade, a partir de três blocos temáticos que dialogam entre si: mediação do conhecimento culinário; consumo alimentar midiatizado, e distinção social e capitais midiáticos.
CERATOCISTO ODONTOGÊNICO EM REGIÃO DE CORPO MANDIBULAR: RELATO DE CASO CLÍNICO
Authors: Cabral Farah Paixão Renan 
Published: November 2019

RESUMOO ceratocisto odontogênico consiste em uma patologia benigna atualmente classificada pela OMS como cisto odontogênico de desenvolvimento. Acredita-se que se desenvolve a partir de restos celulares da lâmina dentária acometendo, principalmente a região posterior de mandíbula. Seu aspecto agressivo e seu potencial de recidiva conferem a esse cisto a necessidade de tratamento adjacente das suas margens, além da enucleação. O objetivo desse trabalho é relatar um caso de ceratocisto odontogênico em região de corpo mandibular de um paciente, sexo masculino de 45 anos. O tratamento cirúrgico estabelecido foi de enucleação da lesão e curetagem associada a ostectomia periférica das margens e o acompanhamento pós-operatório de seis meses não apresentou recidiva da lesão. O paciente foi orientando quanto a necessidade de acompanhamento radiográfico. A enucleação seguida de tratamento complementar do osso adjacente é um dos tratamentos indicados para lesões císticas recidivantes e se mostrou eficiente no caso relatado.Palavras-chave: Patologia bucal; Ceratocisto odontogênico; enucleaçãoABSTRACTOdontogenic keratocyst is a benign pathology currently classified by the WHO as a developmental odontogenic cyst. It is believed that it develops from dental lamina cell debris, affecting mainly the posterior mandible region. Its aggressive aspect and its recurrence potential give this cyst the need for adjacent treatment of its margins, besides enucleation. This paper aims to report a case of odontogenic keratocyst in the mandibular body region of a 45-year-old male patient. The surgical treatment established was lesion enucleation and curettage associated with peripheral osteotomy of the margins and the postoperative follow-up of six months showed no recurrence of the lesion. The patient was advised about the need for radiographic follow-up. Enucleation followed by complementary treatment of adjacent bone is one of the indicated treatments for relapsing cystic lesions and proved to be efficient in the reported case.Key Words: Odontogenic keratocyst; jaw
Analisis Pektin Albedo Buah Jeruk Pamelo sebagai Adsorben Logam Berat Timbal (Pb), Kadmium (Cd) dan Tembaga (Cu)
Authors: Tahir Masdiana , Safitri Ineks , Suhaenah Asriani 
Published: November 2019

Pamelo citrus is a fruit plant having the potential to be developed in Indonesia. One of the centers for producing large oranges or Pamelo citrus in South Sulawesi is Pangkep Regency. One of the components of the Pamelo citrus is pectin. Pectin is a polysaccharide compound with a high molecular weight which is widely found in plants and it can absorb metals because they contain carboxylic groups. This study aimed to analyze pectin from albedo pamelo citrus fruit as an adsorbent for heavy metal plumbum (Pb), cadmium (Cd) and copper (Cu). The method used was atomic absorption spectrophotometer with the equation analysis of heavy metal adsorption by pectin of pamelo citrus determined by Langmuir and Freundlich adsorption isothermal method. The results showed that pectin of albedo pamelo citrus following the isothermal of Freundlich adsorption which showed the adsorbent capacity of Pb, Cd and Cu with the KF values 0.561 mg/g, 0.010 mg/g and 0.066 mg/g, respectively. Meanwhile, n values were 0.823 for Pb, 0.321 for Cd and 1.121 for Cu, and in commercial pectin following the isothermal of Freundlich adsorption with the KF values of Pb, Cd and Cu were 0.650 mg/g, Cd 0.015 and Cu of 0.77 mg/g, respectively. Then the n values were 0.641 for Pb, 0.811 for Cd and 1.183 for Cu.
HUBUNGAN OBESITAS SENTRAL DENGAN MEMORI JANGKA PENDEK MAHASISWA FAKULTAS KEDOKTERAN UNIVERSITAS TADULAKO
Authors: Tinta Iniche , Sumarni Sumarni 
Published: November 2019

Mahasiswa memerlukan memori yang baik sebagai salah satu fungsi kognitif untuk membantu proses belajar. Memori yang baik tergantung pada tingkat aktivasi memori jangka pendek. Perburukan pada memori jangka pendek dapat menyebabkan penurunan kemampuan belajar. Salah satu kondisi yang mempengaruhi pembentukan memori adalah peningkatan profil lipid yang banyak terjadi pada keadaan obesitas sentral. Untuk itu penelitian ini bertujuan untuk mengetahui hubungan obesitas sentral dengan memori jangka pendek pada mahasiswa Fakultas Kedokteran Universitas Tadulako. Penelitian ini merupakan penelitian observasional analitik dengan disain cross sectional. Subjek penelitian berjumlah 87 orang laki-laki dan perempuan usia 16-23 tahun yang diperoleh secara purposive sampling. Penentuan obesitas sentral ditentukan dengan mengukur lingkar perut menggunakan pita pengukur dan penilaian memori jangka pendek menggunakan digit span test. Ukuran rata-rata lingkar perut 91,30 cm dan memori jangka pendek terbanyak adalah kategori sedang. Obesitas sentral memiliki hubungan dengan memori jangka pendek pada mahasiswa Fakultas Kedokteran Universitas Tadulako (p=0.015, r=-0.261). Obesitas sentral berhubungan dengan memori jangka pendek pada mahasiswa Fakultas Kedokteran Universitas Tadulako.
The Impact of Reported Cybersecurity Breaches on Firm Innovation
Authors: He Chris Zhijian , Frost Tracie , Pinsker Robert E. 
Published: November 2019

ABSTRACT
Many firms cite cyber risk as a primary risk factor due to the increase in cybersecurity breach (CSB) incidents. Existing research focuses on the negative, short-term impacts from CSBs, but the longer-term impact is still unknown. Our study investigates firms' levels of innovation following a CSB as an important determinant of firm growth and profitability. Examining reported breaches from 2005–2014, we find a 10 percent decline in research and development spending in the year following a CSB. Further investigation indicates that firms for which R&D is not the primary business model drive the results. We also provide evidence of a decrease in patents two years after a breach, an increase in cash holdings in the year after the breach, and a decrease in investment efficiency four years following the breach. Our aggregate results suggest that CSBs are associated with future strategic decisions involving firm-level innovation and investment decisions.
Data Availability: Data are available from the public sources cited in the text.