bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wearable Systems of Reconfigurable Microneedle Electrode Array for Subcutaneous Multiplexed Recording of Myoelectric and Electrochemical Signals
Authors: Liu Zhengjie , Yao Chuanjie , Xu Xingyuan , Huang Xinshuo , Huang Shuang , Zheng Shantao , Zhang Tao , Li Yan , Liu Fanmao , Wu Yuxiang , Liu Jing , Chen Hui‐jiuan , Xie Xi 
Published: December 2024

AbstractThe real‐time monitoring of in vivo electrophysiological and biochemical signals provides critical insights into the activities of tissues and organs. As the activity and metabolic state of different sites in the muscle vary, multichannel detection is necessary to capture the functional state of the whole muscle, yet the access to the bio‐information in subcutaneous space remained challenging. This work reports the development of a reconfigurable microneedle electrode array integrated system designed to achieve painless and minimally invasive monitoring of subcutaneous electromyogram (EMG), oxygen species, and pH through an array of thumbtack‐shaped microneedle (TSMN) electrode. By assembling discrete TSMNs into an array, the system enables multi‐parameter detection with single microneedle resolution. The PEDOT: PSS layer is electrochemically deposited on the TSMNs, enhancing their signal‐sensing capabilities and electrochemical properties. Additionally, the design of the pogo pin interface ensures reliable signal transmission and stable device performance, while allowing flexible replacement of the TSMNs, which enhances system maintainability and longevity. Validation experiments conducted on in vivo animal models demonstrate the system's capability in real‐time monitoring of muscle fatigue and indicators related to sciatic nerve injury. These results advance the development of wearable technologies for monitoring subcutaneous physiological and biochemical information for diagnosing neuromuscular disorders.
Activatable Sulfur Dioxide Nanosonosensitizer Enables Precisely Controllable Sono‐Gaseous Checkpoint Trimodal Therapy for Orthotopic Hepatocellular Carcinoma
Authors: Liang Jing , Cheng Guangwen , Qiu Luping , Xue Liyun , Xu Huning , Qiao Xiaohui , Guo Na , Xiang Huijing , Chen Yu , Ding Hong 
Published: December 2024

AbstractImmune checkpoint blockade (ICB) is combined with sonodynamic therapy (SDT) to increase response rates and enhance anticancer efficacy. However, the “always on” property of most sonosensitizers in reducing tumor microenvironment (TME) compromises the therapeutic outcome of sonoimmunotherapy and exacerbates adverse side effects. Precisely controllable strategies combining sulfur dioxide (SO2) gas therapy with cancer immunotherapy can address these issues but remain lacking. Herein an “activatable SO2 nanosonosensitizer” for precise sono‐gaseous checkpoint trimodal therapy of orthotopic hepatocellular carcinoma (HCC) is reported, whose full activity is initiated by ultrasound (US) irradiation in the reducing TME. This “activatable SO2 nanosonosensitizer,” Aza‐DNBS nanoparticles (NPs), are established by self‐assembling Aza‐boron‐dipyrromethene based sonosensitizer molecules and 2,4‐dinitrobenzenesulfonate (DNBS)‐caged SO2 prodrug. The activity of Aza‐DNBS NPs is initially silenced, and the sonodynamic, gaseous, and immunosuppressive TME reprogramming activities are precisely awakened under US irradiation. Due to the glutathione‐responsiveness of Aza‐DNBS NPs, Aza‐DNBS NPs can generate large amounts of SO2 for gas therapy‐enhanced SDT, which triggers robust immunogenic cell death activation and reprogramming of the immunosuppressive TME, thereby significantly suppressing orthotopic tumor growth and delaying lung metastasis. Thus, this study represents a strategy for designing a generic nanoplatform for precisely combined immunotherapy of orthotopic HCC.
Targeted Delivery of c(RGDfk)‐Modified Liposomes to Bone Marrow Through In Vivo Hitchhiking Neutrophils for Multiple Myeloma Therapy
Authors: Liu Huiwen , Zhang Bo , Chen Hongrui , Wang Honglan , Qin Xifeng , Sun Chunyan , Pang Zhiqing , Hu Yu 
Published: December 2024

AbstractMultiple myeloma (MM) is a prevalent bone marrow disorder. The challenges in managing MM include selecting chemotherapy regimens that effectively modulate the myeloma microenvironment and delivering them to the bone marrow with high efficacy and minimal toxicity. Herein, a novel bone marrow targeting strategy using c(RGDfk) peptide‐modified liposomes loaded with chemotherapeutics is developed, which can specifically recognize and hitchhike neutrophils following systemic administration, capitalizing on their natural aging process to facilitate precise drug delivery to the bone marrow, thus minimizing off‐target effects. On the one hand, c(RGDfk)‐functionalized liposomes containing carfilzomib (CRLPs) successfully transformed macrophages from M2 phenotype to M1 phenotype, enhancing immunotherapeutic responses. On the other hand, c(RGDfk)‐functionalized liposomes encapsulating BMS‐202 (BRLPs), a small molecule checkpoint inhibitor, interrupted the PD‐1/PD‐L1 axis and promoted the infiltration of cytotoxic T cells. The co‐administration of CRLPs and BRLPs successfully delivered drugs to bone marrow, leading to significant modulation of the myeloma microenvironment, reduced tumor growth, and improved survival time of MM‐bearing mouse models. These findings introduced an alternative approach to modulating the myeloma microenvironment and underscored the efficacy of hitchhiking neutrophils for bone marrow drug delivery. This strategy show advantages over traditional drug delivery methods in terms of improved efficacy and lowered toxicity.
Ternary Logic Transistors Using Multi‐Stacked 2D Electron Gas Channels in Ultrathin Oxide Heterostructures
Authors: Choi Ji Hyeon , Seok Tae Jun , Kim Sang June , Dae Kyun Seong , Jang Jae Hyuck , Cho Deok‐Yong , Lee Sang Woon , Park Tae Joo 
Published: December 2024

Abstract2D electron gas field‐effect transistors (2DEG‐FETs), employing 2DEG formed at an interface of ultrathin (≈6 nm) Al2O3/ZnO heterostructure as the active channel, exhibit outstanding drive current (≈215 µA), subthreshold swing (≈132 mV dec−1), and field effect mobility (≈49.6 cm2 V−1 s−1) with a high on/off current ratio of ≈107. It is demonstrated that the Al2O3 upper layer in Al2O3/ZnO heterostructure acts as the source/drain resistance component during transistor operations, and the applied potential to the 2DEG channel is successfully modulated by Al2O3 thickness variations so that the threshold voltage (Vth) is effectively tuned. Remarkably, double‐stacked 2DEG‐FETs consisting of two Al2O3/ZnO heterostructured 2DEG channels with a single gate exhibit multiple Vth, enabling a ternary logic state in a single device. By inducing a voltage difference between the stacked channels, a sequential operation of the upper and lower FETs is achieved, successfully realizing a stable ternary logic operation.
Dipeptidyl Peptidase 4 (DPP4) Exacerbates Osteoarthritis Progression in an Enzyme‐Independent Manner
Authors: Li Xinyu , Zhang Zhao , Jiang Wenyu , Ju Yucan , Guo Weihua , Huang Zeyu 
Published: December 2024

AbstractChondrocyte senescence is a key driver of osteoarthritis (OA). Mitochondrial dysfunction and oxidative stress can induce chondrocyte senescence. However, the specific mechanisms by which senescence contributes to OA progression are not fully understood. Here, it is attested that Dipeptidyl peptidase 4 (DPP4) is significantly upregulated in osteoarthritic chondrocytes in both humans and mice. DPP4 promotes oxidative stress and cellular senescence in chondrocytes through excessive mitochondrial fission in an enzyme‐independent manner. Intra‐articular injection of adeno‐associated virus 2 to upregulate DPP4 in chondrocytes promotes post‐traumatic and aging‐induced OA in mice in an enzyme‐independent manner. Mechanistically, DPP4 competitively binds to Myosin heavy chain 9 (MYH9), interfering with its E3 ubiquitin ligase Carboxyl terminus of Hsc70‐interacting protein (CHIP), and thereby upregulates MYH9 expression. Finally, a small molecule, 4,5‐Dicaffeoylquinic acid is identified, which disrupts the interaction between DPP4 and MYH9, thereby ameliorating post‐traumatic and aging‐induced OA in mice caused by DPP4 upregulation. The study indicates that the non‐enzymatic activity of DPP4 is a promising target for OA treatment.
Substantial Heritability Underlies Fairness Norm Adaptation Capability and its Neural Basis
Authors: Jin Yuening , Zheng Dang , Gu Ruolei , Fan Qingchen , Dietz Martin , Wang Changshuo , Li Xinying , Chen Jie , Hu Yuanyuan , Zhou Yuan 
Published: December 2024

AbstractThe present research uncovers the shared genetic underpinnings of fairness norm adaptation capability, its neural correlates, and long‐term mental health outcomes. One hundred and eighty‐six twins are recruited and played as responders in the Ultimatum Game (UG) while undergoing fMRI scanning in their early adulthood (Study‐1) and are measured on depressive symptoms eight years later (Study‐2). With computational modeling, the process of norm adaptation is differentiated from that of fairness valuation in UG. The two processes both have moderate levels of heritability. The anterior insula has a significant phenotypic correlation, whereas the Supplementary Motor Area/Medial Frontal Gyrus (SMA/mSFG) shows both a significant phenotypic correlation and a shared genetic influence with the learning rate, an index for norm adaptation. The dopaminergic DRD2 polymorphisms correlate with both the learning rate and the SMA/mSFG encoding of prediction error, constituting of their common genetic basis. Regional gene expression analysis reveals the high expression of dopamine‐related genes in the SMA/mSFG. Moreover, the learning rate can predict depressive symptom severity eight years later, with the DRD2 polymorphisms constituting their shared genetic basis. This suggests that heritability is a non‐negligible driving force behind norm adaptation, which facilitates the learning of social norms in changing environments and preserves long‐term mental health.
Mesenchymal Stem Cells Prevent SLC39A14‐Dependent Hepatocyte Ferroptosis through Exosomal miR‐16‐5p in Liver Graft
Authors: Deng Zhizhao , Zeng Weiqi , Gao Yingxin , Yang Zhenyu , Luo Xinling , Li Xianlong , Sun Guoliang , Xiong Erfeng , Huang Fei , Luo Gangjian , Hei Ziqing , Yuan Dongdong 
Published: December 2024

AbstractIschemia‐reperfusion injury (IRI) is the leading cause of hepatic graft dysfunction, resulting from hepatocyte damage. Nevertheless, given the few specialized therapeutics available in hepatic IRI, additional mechanistic insights into hepatocyte damage are required. Here, the protein solute carrier family 39 member 14 (SLC39A14) is identified as a pro‐ferroptosis target in hepatocytes of human liver allografts through single‐cell RNA sequencing analysis. SLC39A14 knockdown significantly mitigated hepatic IRI by preventing hepatocyte ferroptosis in vivo and in vitro. Mechanistically, the inhibition of SLC39A14 suppressed non‐transferrin‐bound iron (NTBI) uptake by hepatocytes, thereby reducing iron overload and cell ferroptosis. Moreover, human bone marrow‐derived mesenchymal stem cells (hBMSCs) are found to exhibit a notable therapeutic effect on hepatic IRI by downregulating SLC39A14 expression. Exosomes derived from hBMSCs delivered abundant miR‐16‐5p into hepatocytes, which post‐transcriptionally suppressed the expression of SLC39A14 and reduced cell ferroptosis induced by hepatic IRI. In conclusion, SLC39A14 triggers hepatic IRI by mediating NTBI uptake into hepatocytes and inducing hepatocyte ferroptosis. Moreover, hBMSC‐based therapy is promising to reverse this progression of hepatic IRI.
Entropy‐Mediated Crystallization Manipulation in Glass
Authors: Feng Xu , Gao Guanfeng , Lin Quanhua , Yang Yongkang , Tan Jiajia , Liu Ziang , Qiu Jianrong , Jiang Xiaofang , Zhou Shifeng 
Published: December 2024

AbstractThe entropy mediated temperature‐structure evolution has attracted significant interest, which is used for the development of functional alloys and ceramics. But such strategy has not yet been demonstrated for development of non‐metallic glasses. Herein, the successful application of the entropy engineering concept to non‐metallic glass to manipulate its in situ crystallization process is demonstrated. The comparison of the entropy concept in alloys, ceramics, and non‐metallic glass is discussed. As a typical example, the activation and preservation of the entropy stabilized effect of a typical niobosilicate glass system at different temperatures are studied. The relation between the micro‐configurations and the entropic property is analyzed. Via the entropy engineering strategy, the crystallization of the niobosilicate glass can be manipulated. As a result, the LiNbO3 nanocrystal‐in‐glass (NiG) composite with high crystallinity is developed, which exhibits 8 times higher nonlinearity compared with the β‐BBO crystal. The developed NiG composite is demonstrated for practical application in precise measurement of the duration and phase of ultra‐short femtosecond pulse.
Suppressed Protein Translation Caused by MSP‐8 Deficiency Determines Fungal Multidrug Resistance with Fitness Cost
Authors: Zhou Mi , Yu Pengju , Hu Chengcheng , Fang Wenxia , Jin Cheng , Li Shaojie , Sun Xianyun 
Published: December 2024

AbstractAntifungal resistance, particularly the rise of multidrug‐resistance strains, poses a significant public health threat. In this study, the study identifies a novel multidrug‐resistance gene, msp‐8, encoding a helicase, through experimental evolution with Neurospora crassa as a model. Deletion of msp‐8 conferred multidrug resistance in N. crassa, Aspergillus fumigatus, and Fusarium verticillioides. However, the transcript levels of genes encoding known drug targets or efflux pumps remain unaltered with msp‐8 deletion. Interestingly, MSP‐8 interacted with ribosomal proteins, and this mutant displays compromised ribosomal function, causing translational disturbance. Notably, inhibition of protein translation enhances resistance to azoles, amphotericin B, and polyoxin B. Furthermore, MSP‐8 deficiency or inhibition of translation reduces intracellular ketoconazole accumulation and membrane‐bound amphotericin B content, directly causing antifungal resistance. Additionaly, MSP‐8 deficiency induces cell wall remodeling, and decreases intracellular ROS levels, further contributing to resistance. The findings reveal a novel multidrug resistance mechanism independent of changes in drug target or efflux pump, while MSP‐8 deficiency suppresses protein translation, thereby facilitating the development of resistance with fitness cost. This study provides the first evidence that MSP‐8 participates in protein translation and that translation suppression can cause multidrug resistance in fungi, offering new insights into resistance mechanisms in clinical and environmental fungal strains.
High‐Spin States of Manganese(III) Enable Robust Cold‐Adapted Activity of MnO2 Nanozymes
Authors: Tian Qing , Huangfu Shuaiqi , Kang Ge , Wang Haoyu , Liu Huile , Wang Xuejing , Li Aipeng , Chen Yao , Fan Kelong , Zhang Lianbing 
Published: December 2024

AbstractDeveloping novel cold‐adapted nanozymes and elucidating their mechanisms of action remains a great challenge. Inspired by natural oxidases that utilize high‐spin and high‐valent metal‐oxygen intermediates to achieve high efficiency at low temperatures, in this study, a series of MnOx nanomaterials with varied valence and spin states are synthesized. The activity assay revealed that the oxygen vacancy‐engineered ε‐MnO2 nanozyme displayed excellent cold‐adapted oxidase‐like properties, and no observable activity loss is observed in the temperature range of −20 to 45 °C. The superior performance is attributed to the high‐spin Mn(III)–O species coupled with its induced Jahn–Teller effect, which facilitates the dissociation and activation of oxygen at low temperatures. As a proof of concept, an excellent cold‐adapted δ‐MnO2 nanozyme can be obtained using Mn3O4 as the precursor by regulating the spin state of Mn(III). Moreover, a novel and effective degradation strategy for corn stalk at low temperature is built based on the robust cold‐adapted oxidase‐like activity of ε‐MnO2. These results not only provide new insights for the rational design of cold‐adapted nanozymes but also broaden the application of nanozymes in low‐temperature industrial processes.
Photoinduced Melting of V4O7 Correlated State
Authors: Bartenev Alexander , Verbel Camilo , Wu Qin , Camino Fernando , Rúa Armando , Lysenko Sergiy 
Published: December 2024

AbstractThe compound V4O7 is one of the Magnéli phase (VnO2n − 1, n = 3, 4, …, 9) correlated vanadium oxides with distinct intriguing electronic and structural properties. The possibility to manipulate the phase state of V4O7 on an ultrafast time scale by light makes this material promising for potential applications in photonics, optoelectronics, quantum, and neuromorphic circuit design. In this work, the ultrafast spectroscopy of V4O7 reveals the second‐order nature of the photoinduced insulator‐to‐metal transition, emphasizing electronic and lattice contributions. The findings reveal the influence of the laser excitation level and temperature on these dynamics, providing a comprehensive understanding of V4O7 structural changes and response to external stimuli. The phenomenological model based on the Landau–Ginzburg formalism provides a robust framework for explaining the photoinduced transition dynamics, showing a detailed picture of the light interaction with the electronic and lattice subsystems. This integrated approach significantly enhances the understanding of V4O7 complex behavior upon photoexcitation, opening new possibilities for developing new optoelectronic devices and noninvasive optical control of the phase transition pathways in vanadates.
Ferroelectric‐Assisted Ion Dynamics for Prolonged Tactile Cognizance in a Biomimetic Memory‐in‐Sensor System
Authors: Bhunia Ritamay , Kim Joo Sung , Oh Hayoung , Kim Dong Jun , Lee Seokyeong , Park Cheolmin , Kim Do Hwan 
Published: December 2024

AbstractThe advancements in developing low‐powered artificial tactile cognition devices, inspired by the iontronic‐reliant human haptic sensory system, show great potential in future robotics and prosthetics. However, poor tactile memory and the complexity of integrating diverse modules for tactile sensing and neuromorphic functionalities pose a formidable challenge. Here, a mechanoreceptor‐inspired tactile memory‐in‐sensor (TMIS) device is presented, employing ferroelectric‐assisted ion dynamics (FAID) in FAID‐based synaptic tactile transistor (FAID‐STT). This approach improves the long‐term memory (LTM) of tactile information while minimizing power consumption, all within a unified device architecture of TMIS. The FAID mechanism intricately combines the release of trapped ions solely under mechanical stress with remnant ferroelectric polarization induced by voltage stimulation, ensuring prolonged memory retention. Consequently, the FAID‐STT exhibits a voltage‐dependent memory effect stemming from the augmentation of ferroelectric dipole polarization, offering uninterrupted tactile memory for over 12 min without requiring additional power inputs for memory retention.
Regulating and Stabilizing Strong Metal‐Support Interactions on Ni/TiO2 by Crystal Phase for Ultra‐Stable Ethanol Reforming
Authors: Zhu Songshan , Ma Shimin , Song Di , He Sufang , Wang Yunzhu , Lu Jichang , Ai Tianhao , Luo Yongming 
Published: December 2024

AbstractThe regulation and stabilization of strong metal‐support interactions (SMSI) in high temperature hydrogen‐rich reaction condition remains a huge challenge due to its structural sensitivity. Herein, tunable SMSI is constructed and stabilized on TiO2 supported Ni catalysts by TiO2 crystal phase engineering strategy, and then a SMSI‐degree‐depended ethanol stream reforming (ESR) performance is demonstrated. Rutile supported Ni exhibited a weakened SMSI with 48.6% coverage, exposing more metallic Ni and Ni‐TiO2 perimeter interface sites, and displayed exceptional H2 yield of 4.7 molH2/molethanol and an ultra‐long stability of 420 h without deactivation at 500 °C. The low reaction energy and high resistance to carbon deposition (0.9 mgc/gcat·h) and Ni0 sintering on Ni/r‐TiO2 catalyst explained its excellent catalytic performance. Furthermore, the effect of well‐defined SMSI structures on the reaction pathway and deactivation mechanism of the ESR is clarified. This work provides a precedent for the tailor and application of SMSI in high temperature hydrogen‐rich reaction conditions.
Microstructure of Lithium Metal Electrodeposited at the Steel|Li6PS5Cl Interface in “Anode‐Free” Solid‐State Batteries
Authors: Becker Juri , Fuchs Till , Ortmann Till , Kremer Sascha , Richter Felix H. , Janek Jürgen 
Published: December 2024

AbstractRecent research shows that integrating lithium metal anodes can enhance battery energy density, but the high reactivity of lithium requires handling under inert conditions to avoid degradation. To overcome this, reservoir‐free cells (RFCs) are explored, where lithium metal is electrodeposited at the current collector (CC) and solid electrolyte (SE) interface during initial charging. The electrochemical properties of electrodeposited lithium are influenced by its morphology and microstructure, which impact lithium discharge capacity and pore formation. However, little is known about how to control the microstructure of electrodeposited lithium. This work experimentally characterizes the lithium microstructure at the steel|Li6PS5Cl interface using cryogenic ion beam milling, scanning electron microscopy (SEM), and electron backscatter diffraction (EBSD), focusing on the effects of electrodeposition current density and lithium layer thickness. The results show that layer thickness, not current density, primarily governs the lithium microstructure. This “specimen thickness effect” is qualitatively described using a Monte Carlo Potts model and indicates that electrodeposited lithium metal quickly equilibrates at room temperature.
Calciumchemie als ein neues Mitglied der Post‐Lithium‐Batteriefamilie: Was können wir von Natrium‐ und Magnesium‐Systemen lernen
Authors: Li Zhenyou , Cui Shuangshuang , Häcker Joachim , Nojabaee Maryam , Fichtner Maximilian , Cui Guanglei , Zhao‐Karger Zhirong 
Published: December 2024

AbstractBei der Entwicklung von Batterietechnologien der nächsten Generation müssen die Umweltauswirkungen während der gesamten Lebensdauer berücksichtigt werden, was neue Batteriechemie auf der Basis von häufig auf der Erde vorkommenden Elementen ins Rampenlicht gerückt hat. Wiederaufladbare Calciumbatterien sind eine solche vielversprechende Technologie, die das Potenzial zeigt, eine hohe Zellspannung und eine hohe Energiedichte zu liefern, die denen von Lithium‐Ionen‐Batterien nahekommt. Darüber hinaus ist die Verwendung von Ca2+ als Ladungsträger sehr nachhaltig. Obwohl seit mehr als einem halben Jahrhundert Pionierarbeit in der Elektrochemie von Ca geleistet wird, gelang es erst im letzten Jahrzehnt, reversible Ca0/Ca2+ Redoxchemie in nicht‐wässrigen Medien zu zeigen. In dieser Übersicht werden wir die jüngste Entwicklung wiederaufladbarer Calciumbatterien vorstellen und uns dabei hauptsächlich auf die Ähnlichkeiten, aber auch auf die Unterschiede zwischen der Ca‐Chemie und anderer Post‐Lithium‐Chemie konzentrieren. Gemäß der periodischen Natur der Elemente haben Magnesium (ein Erdalkalielement wie Ca) und Natrium (ein diagonal benachbartes Element zu Ca) in vielerlei Hinsicht ähnliche chemische Eigenschaften wie Ca. Wir werden erläutern, wie die Lösungschemie, das Metallverhalten und die Transportmechanismen von Ca‐Ionen im Lichte der etablierten Prinzipien in den jeweiligen Mg/Na‐Systemen besser verstanden werden können. Wir hoffen, dass die Diskussion zu einer synergetischen Entwicklung zwischen Ca‐Batterien und anderen Post‐Lithium‐Systemen anregen wird.