bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low‐Temperature Charge/Discharge of Rechargeable Battery Realized by Intercalation Pseudocapacitive Behavior
Authors: Dong Xiaoli , Yang Yang , Wang Bingliang , Cao Yongjie , Wang Nan , Li Panlong , Wang Yonggang , Xia Yongyao 
Published: June 2020

AbstractConventional intercalation compounds for lithium‐ion batteries (LIBs) suffer from rapid capacity fading and are even unable to charge–discharge with temperature decline, owing to the sluggish kinetics and solvation/desolvation process. In this work, a high‐performance rechargeable battery at ultralow temperature is developed by employing a nanosized Ni‐based Prussian blue (NiHCF) cathode. The battery delivers a high capacity retention of 89% (low temperature of −50 °C) and 82% (ultralow temperature of −70 °C) compared with that at +25 °C. Various characterizations and electrochemical investigations, including operando Fourier transform infrared spectra, in situ X‐ray diffraction, cyclic voltammetry response, and galvanostatic intermittent titration technique are carried out to detect the structural stability and electrochemical behavior at different temperatures. It turns out that the pseudocapacitive behavior drives the desolvation process at the interface, while fast diffusion in the bulk electrode accelerates the movement of Li+ from the interface to the bulk materials. The unique synergistic features of intercalation pseudocapacitance at the electrolyte/electrode interface and high diffusion coefficient in the bulk electrode enables the NiHCF cathode with excellent low temperature performance. These findings offer a new direction for the design of LIBs operated at low temperature.
Ferrofluid Microdroplet Splitting for Population‐Based Microfluidics and Interfacial Tensiometry
Authors: Latikka Mika , Backholm Matilda , Baidya Avijit , Ballesio Alberto , Serve Amandine , Beaune Grégory , Timonen Jaakko V. I. , Pradeep Thalappil , Ras Robin H. A. 
Published: June 2020

AbstractFerrofluids exhibit a unique combination of liquid properties and strong magnetic response, which leads to a rich variety of interesting functional properties. Here, the magnetic‐field‐induced splitting of ferrofluid droplets immersed in an immiscible liquid is presented, and related fascinating dynamics and applications are discussed. A magnetic field created by a permanent magnet induces instability on a mother droplet, which divides into two daughter droplets in less than 0.1 s. During the splitting process, the droplet undergoes a Plateau–Rayleigh‐like instability, which is investigated using high‐speed imaging. The dynamics of the resulting satellite droplet formation is shown to depend on the roughness of the supporting surface. Further increasing the field results in additional splitting events and self‐assembly of microdroplet populations, which can be magnetically actuated. The effects of magnetization and interfacial tension are systematically investigated by varying magnetic nanoparticles and surfactant concentrations, and a variety of outcomes from labyrinthine patterns to discrete droplets are observed. As the splitting process depends on interfacial tension, the droplet splitting can be used as a measure for interfacial tension as low as 0.1 mN m−1. Finally, a population‐based digital microfluidics concept based on the self‐assembled microdroplets is presented.
Multiple‐Frequency High‐Output Triboelectric Nanogenerator Based on a Water Balloon for All‐Weather Water Wave Energy Harvesting
Authors: Xia Kequan , Fu Jiangming , Xu Zhiwei 
Published: June 2020

AbstractEnergy and the environment are two of the main issues facing the world today. As a consequence abundant renewable green energy sources such as wave energy, have become hot topics. Here, a multiple‐frequency triboelectric nanogenerator based on the water balloon (WB‐TENG) is proposed for harvesting water wave energy in any direction. Owing to the high elasticity of the water balloon, the WB‐TENG can realize a multiple‐frequency response to low‐frequency external mechanical simulations to generate high‐frequency electrical output. In addition, the water balloon can achieve self‐support without any additional supporting structure because of its tension, to make WB‐TENG still produce electrical output under slight vibration, which can also bring high energy conversion efficiency. Moreover, the fabricated WB‐TENG generates a maximum instantaneous short‐circuit current and an open‐circuit voltage of 147 µA and 1221 V, respectively. Most noteworthy, under the same conditions, the total transferred charge of WB‐TENG is 28 times than that of traditional TENG based on double plate structure during one working cycle. Therefore, this design can provide an effective way to promote the development of TENGs in blue energy.
A novel risk‐scoring system for predicting lymph node metastasis of rectal neuroendocrine tumors
Authors: Chida Keigo , Watanabe Jun , Hirasawa Kingo , Inayama Yoshiaki , Misumi Toshihiro , Kunisaki Chikara , Endo Itaru 
Published: June 2020

AbstractAimAlthough rectal neuroendocrine tumors (NETs) are considered to be rare low‐grade malignancies when lymph node metastasis (LNM) is present, their degree of malignancy is comparable to that of colorectal cancer (CRC). However, it remains unclear as to which patients require radical lymph node dissection. The aim of this study was to elucidate the risk factors for LNM and develop a risk‐scoring system for LNM to help determine appropriate therapeutic approaches.MethodsIn this study, we examined 103 patients with rectal NETs who underwent local resection (n = 55) or radical resection with LN dissection (n = 48). We evaluated each pathological feature, including the depth of submucosal invasion (SM depth) and tumor budding grade.ResultsAccording to our univariate analyses and previous reports, the significant five risk factors for LNM were weighted with point values: 2 points for tumor size ≥ 15 mm and muscularis invasion, and 1 point each for SM depth ≥ 2000 µm, positive lymphovascular invasion, budding grade 3, and vertical margin. The area under the receiver operating curve for the scoring system was 0.899 (95% CI: 0.843‐0.955). When a score of 2 was used as the cut‐off value, the sensitivity and specificity for the prediction of LNM were 100% and 72.1%, respectively.ConclusionsThe risk‐scoring system for LNM of rectal NETs showed high diagnostic performance. Using this risk‐scoring system, it is possible to predict the risk of LNM and thereby potentially avoid unnecessary surgery. Further prospective external validation studies should be performed. The study was registered in the Japanese Clinical Trials Registry as UMIN000036658.
Near‐Zero‐Sidelobe Optical Subwavelength Asymmetric Focusing Lens with Dual‐Layer Metasurfaces
Authors: Xie Jianlan , Liang Shengnan , Liu Jianjun , Tang Pinghua , Wen Shuangchun 
Published: June 2020

AbstractExisting metasurfaces with ultrathin volume for asymmetric transmission are often constructed from metal with low efficiency in optical frequencies, and cannot realize optical asymmetric transmission and focusing simultaneously. Although acoustic asymmetric focusing in asymmetric focusing lenses (AFL) has been realized, the obtained focal point is accompanied by a large sidelobe. To solve these problems, an AFL with dual‐layer metasurfaces designed by using impedance matching materials can realize optical asymmetric transmission and focusing simultaneously in this paper. Furthermore, through optimizing the design theory of AFL, near‐zero‐sidelobe (NZS) focusing can be realized on the subwavelength scale. NZS asymmetric focusing of the optimized AFL is effective in broadband, which is expected to show tremendous potential in optical micro‐nanoprocessing, quantum communication, optical micromanipulation, etc.
Trehalose against Alzheimer's Disease: Insights into a Potential Therapy
Authors: Khalifeh Masoomeh , Read Morgayn I. , Barreto George E. , Sahebkar Amirhossein 
Published: June 2020

AbstractTrehalose is a natural disaccharide with a remarkable ability to stabilize biomolecules. In recent years, trehalose has received growing attention as a neuroprotective molecule and has been tested in experimental models for different neurodegenerative diseases. Although the underlying neuroprotective mechanism of trehalose's action is unclear, one of the most important hypotheses is autophagy induction. The chaperone‐like activity of trehalose and the ability to modulate inflammatory responses has also been reported. There is compelling evidence that the dysfunction of autophagy and aggregation of misfolded proteins contribute to the pathogenesis of Alzheimer's disease (AD) and other neurodegenerative disorders. Therefore, given the linking between trehalose and autophagy induction, it appears to be a promising therapy for AD. Herein, the published studies concerning the use of trehalose as a potential therapy for AD are summarized, providing a rationale for applying trehalose to reduce Alzheimer's pathology.
Use of acetylacetone for nano‐level assay of fluvoxamine maleate in pure form and pharmaceutical formulation
Authors: Abu‐hassan Ahmed A. , Omar Mahmoud A. , Derayea Sayed M. 
Published: June 2020

AbstractThe present study developed and validated a selective spectrofluorimetric method designed to assay fluvoxamine maleate (FLX). The validated method relied on the condensation reaction between FLX and acetylacetone/formaldehyde using acetate buffer (pH 4.2). The formed fluorescent product was measured at an emission wavelength of 479 nm after excitation at 419 nm. Parameters that influenced the reaction were studied and adjusted accurately. The constructed calibration graph was rectilinear over the range 200–2000 ng ml−1 and the estimated limit of detection was 60 ng ml−1. Two products from an Egyptian market were assayed using the suggested method and the final results agreed with the measurements of the reported method. The selectivity of the proposed approach was evaluated using the standard addition method and results were acceptable and confirmed the reliability of this approach. Finally, directives from the International Council for Harmonisation guidelines were applied to establish the validity of the study.
Radiotherapy followed by DICEP regimen in treatment of newly diagnosed, stage IE/IIE, extranodal NK/T‐cell lymphoma patients
Authors: Liu Yizhen , Xue Kai , Xia Zuguang , Jin Jia , Wang Jiachen , Sun Hui , Lv Fangfang , Liu Xiaojian , Cao Junning , Hong Xiaonan , Guo Ye , Ma Xuejun , Zhang Qunling 
Published: June 2020

AbstractBackgroundThe optimal treatment strategies for extranodal natural killer/ T‐cell lymphoma (ENKTL) have not been defined. We conducted this prospective, open‐label, phase II, single‐center study aimed to explore the efficacy and safety of radiotherapy followed by DICEP (Dexamethasone, ifosfamide, cisplatin, etoposide, and pegaspargase) regimen in the treatment of patients with untreated, stage IE/IIE, extranodal NK/T‐cell lymphoma.MethodsThirty eligible patients were enrolled in this study, receiving radiotherapy of 50Gy/25fx, and followed by chemotherapy with DICEP regimen for 3 cycles if tolerated. Median follow‐up time of this study was 70.8 months. We constructed Kaplan‐Meier survival curves for survival analyses.ResultsThe most common manifestations at the onset of disease were nasal obstruction (80%), with or without fever, and pharyngalgia (20%). The overall response rate (ORR) was 96.7% (29/30). Four patients (13.3%) had progression of the disease (PD), the estimated 5‐year progression‐free survival (PFS) rate was 86%. Four patients (13.3%) died of disease, and the estimated 5‐year cumulative overall survival (OS) was 87%. The most common hematological toxicity was grade 3 or grade 4 neutropenia, which could be successfully managed via using growth‐stimulating factors or dose modifications. Hypoalbuminemia and decreased fibrinogen are the top two nonhematologic toxicities. No treatment‐related death occurred in this study.ConclusionsOur present study showed that radiotherapy followed by DICEP chemotherapy could be an effective and tolerable treatment modality for newly diagnosed, stage IE/IIE ENKTL patients. Adverse events were predictable and manageable.Trial registrationClinicalTrials.gov Identifier: NCT01667302.Registered: 1 July 2012;
Modified gemcitabine plus nab‐paclitaxel regimen in advanced pancreatic ductal adenocarcinoma
Authors: Rogers Jane E. , Mizrahi Jonathan D. , Xiao Lianchun , Mohindroo Chirayu , Shroff Rachna T. , Wolff Robert , Varadhachary Gauri R. , Javle Milind M. , Overman Michael , Fogelman David R. , Raghav Kanwal P. S. , Pant Shubham , McAllister Florencia 
Published: June 2020

AbstractBackgroundGemcitabine (GEM) plus nab‐paclitaxel (NabP) (GEM 1000 mg/m2 IV over 30 minutes + NabP 125 mg/m2 IV given days 1, 8, and 15 every 28 days) is one of the two standard of care combination therapies for metastatic pancreatic ductal adenocarcinoma (PDAC). Our cancer center has utilized GEM‐NabP given every two‐weeks due to tolerability and patient convenience. Here, we review the safety and efficacy of this modified regimen.MethodsMetastatic PDAC patients (pts) who initiated front‐line or second‐line GEM‐NabP during 2013‐2017 were retrospectively reviewed. Primary objective was overall survival. Secondary objectives were disease control rate, progression‐free survival, and the incidence of dose delays and/or adjustments.ResultsFrom a total of 235 patients, 140 pts received GEM‐NabP front‐line while 95 pts received GEM‐NabP second‐line. Median dosing was 600 mg/m2 at fixed‐dose rate for GEM and 125 mg/m2 for NabP given predominantly (~90%) every two‐weeks. Eastern Cooperative Group performance status of 0 and 1 pts had front‐line OS of 12.7 and 9.6 months and when given second‐line had OS of 8 months and 7.3 months, respectively. ECOG 0 and 1 pts had front‐line progression‐free survival (PFS) of 5.3 months and 2.8 months and second‐line PFS was 3.5 months and 2.4 months, respectively. Treatment was well tolerated with limited dose modifications.ConclusionOur analysis revealed safety with every two‐week low dose GEM‐NabP while maintaining efficacy. Patient schedule convenience should factor into metastatic incurable malignancies. We suggest the use of every two‐week GEM‐NabP particularly in patients desiring a modified schedule.
Prognostic implications of baseline 6‐min walk test performance in intermediate risk patients undergoing transcatheter aortic valve replacement
Authors: Sathananthan Janarthanan , Green Philip , Finn Matthew , Wood David A. , Lauck Sandra , Crowley Aaron , Alu Maria , Arnold Suzanne V. , Cohen David , Kapadia Samir , Mack Michael , Thourani Vinod H. , Kodali Susheel , Leon Martin , Webb John G. 
Published: June 2020

AbstractBackgroundWhile slow gait speed is known to be associated with poor outcomes in patients at high surgical risk who undergo transcatheter aortic valve replacement (TAVR), the prognostic significance of slow gait speed in intermediate risk TAVR patients is poorly understood.ObjectivesWe assessed the association between baseline 6‐min walk test (6MWT) performance and both 2‐year mortality and health status in intermediate risk patients undergoing TAVR as a part of the PARTNER II/S3i studies.MethodsThe association of baseline 6MWT with mortality over 2‐years after TAVR was examined using Cox regression; both unadjusted and adjusted for age, left ventricular ejection fraction, coronary artery disease, pulmonary disease, renal insufficiency, and STS score. Patients were divided into four groups according to baseline 6MWT: unable to walk and in three equal tertiles of slow, medium, and fast walkers. Among surviving patients, improvement in 6MWT and quality of life were compared.ResultsAmong 2,037 intermediate risk TAVR patients (mean age 81.7 years, STS score 5.6%), 8.2% were unable to walk. Baseline 6MWT was associated with all‐cause mortality over 2 years (Hazard ratio (HR) 0.87 per 50 m, 95% confidence interval [CI] 0.83 to 0.92, p < .0001). Among surviving patients, the adjusted absolute change in 6MWT at 2 years improved for patients unable to walk (+134.1 m, 95% CI 102.1 to 166 m, p < .0001) and slow walkers (+60.5 m, 95% CI 42.8 to 78.2 m, p < .0001), but was unchanged for medium walkers (−7.3 m, 95% CI −24.3 to 9.6 m, p = .4), and declined for fast walkers (−41.3 m, 95% CI −58.7 to −23.9 m, p < .0001).ConclusionPoor functional capacity is predictive of 2‐year mortality in elderly intermediate risk patients undergoing TAVR. However, surviving patients with poor baseline functional capacity had significant improvement in 6MWT performance and quality of life at 2‐years following TAVR.
Avoidance of bile duct injury during laparoscopic liver cyst fenestration using indocyanine green: A case report
Authors: Hanaki Takehiko , Yagyu Takuki , Uchinaka Ei , Morimoto Masaki , Watanabe Joji , Tokuyasu Naruo , Takano Shuichi , Sakamoto Teruhisa , Honjo Soichiro , Fujiwara Yoshiyuki 
Published: June 2020

AbstractBy administering ICG test immediately before laparoscopic liver cyst fenestration, the biliary tract can be easily identified and intraoperative bile duct damage and postoperative bile fistula formation can be avoided, as demonstrated in this case.
Active Learning A Neural Network Model For Gold Clusters & Bulk From Sparse First Principles Training Data
Authors: Loeffler Troy D. , Manna Sukriti , Patra Tarak K. , Chan Henry , Narayanan Badri , Sankaranarayanan Subramanian 
Published: June 2020

AbstractSmall metal clusters are of fundamental scientific interest and of tremendous significance in catalysis. These nanoscale clusters display diverse geometries and structural motifs depending on the cluster size; a knowledge of this size‐dependent structural motifs and their dynamical evolution has been of longstanding interest. Given the high computational cost of first‐principles calculations, molecular modeling and atomistic simulations such as molecular dynamics (MD) has proven to be an important complementary tool to aid this understanding. Classical MD typically employ predefined functional forms which limits their ability to capture such complex size‐dependent structural and dynamical transformation. Neural Network (NN) based potentials represent flexible alternatives and in principle, well‐trained NN potentials can provide high level of flexibility, transferability and accuracy on‐par with the reference model used for training. A major challenge, however, is that NN models are interpolative and requires large quantities (
or greater) of training data to ensure that the model adequately samples the energy landscape both near and far‐from‐equilibrium. A highly desirable goal is minimize the number of training data, especially if the underlying reference model is first‐principles based and hence expensive. Here, we introduce an active learning (AL) scheme that trains a NN model on‐the‐fly with minimal amount of first‐principles based training data. Our AL workflow is initiated with a sparse training dataset (
1 to 5 data points) and is updated on‐the‐fly via a Nested Ensemble Monte Carlo scheme that iteratively queries the energy landscape in regions of failure and updates the training pool to improve the network performance. Using a representative system of gold clusters, we demonstrate that our AL workflow can train a NN with
500 total reference calculations. Using an extensive DFT test set of ∼1100 configurations, we show that our AL‐NN is able to accurately predict both the DFT energies and the forces for clusters of a myriad of different sizes. Our NN predictions are within 30 meV/atom and 40 meV/Å of the reference DFT calculations. Moreover, our AL‐NN model also adequately captures the various size‐dependent structural and dynamical properties of gold clusters in excellent agreement with DFT calculations and available experiments. We finally show that our AL‐NN model also captures bulk properties reasonably well, even though they were not included in the training data.
Benefit of double‐reading cytology smears as a triage strategy among high‐risk human papillomavirus–positive women in Mexico
Authors: Ramírez‐Palacios Paula , Chen Aiyu , Flores Yvonne N. , Crespi Catherine M. , Lazcano‐Ponce Eduardo , Alvarez‐Escobedo Daniel , Torres‐Ibarra Leticia , Rivera‐Paredez Berenice , León‐Maldonado Leith , Hernández‐López Rubí , Mendiola‐Pastrana Indira R. , Méndez‐Hernández Pablo , Cuzick Jack , Carmona Enrique , Figueroa Héctor , Montiel‐Cordero Fernando , Meneses‐León Joacim , Rao Jianyu , Salmerón Jorge ,   the FRIDA Study Investigators
Published: June 2020

BackgroundThe goal of this study was to determine whether the detection of histologically confirmed cases of cervical high‐grade squamous intraepithelial lesions or worse (HSIL+) can be increased by having each liquid‐based cytology (LBC) slide read by 2 cytotechnologists as part of routine screening.MethodsOver 36,212 women aged 30 to 64 years participated in the Forwarding Research for Improved Detection and Access for Cervical Cancer Screening and Triage (FRIDA) Study in Mexico between 2013 and 2016. For each participant, 2 cervical samples were collected at the same clinic visit, one to test for high‐risk human papillomavirus (hrHPV) and the other for LBC, which was used to triage those with a hrHPV positive result. LBC slides were evaluated by 7 cytotechnologists, with each slide read independently by 2 blinded cytotechnologists. All women with atypical cells of undetermined significance or a worse result were referred to colposcopy for further evaluation and diagnosis. Three pathologists evaluated the biopsy specimens to confirm the final HSIL+ diagnosis. The HSIL+ detection rates for the single versus double reading were estimated and compared.ResultsA total of 3,914 women with a positive hrHPV result were triaged with LBC. The first and second cytology readings resulted in 43 HSIL+ cases detected; the double‐reading strategy detected 9 additional HSIL+ cases, resulting in a total of 52 HSIL+ cases. The HSIL+ detection rate increased from 10.99/1000 with a single reading to 13.29/1000 with the double‐reading strategy (P = .004).ConclusionA 20.9% increase in HSIL+ cases detected was achieved with a double reading of the LBC slides in this sample of hrHPV‐positive women.
Welding flame detection based on color recognition and progressive probabilistic Hough transform
Authors: Chen Weiming , Chen Siqi , Guo Hailin , Ni Xiaoyang 
Published: June 2020

SummaryWelders are widely used in machinery manufacturing and machining industry. In the process of electric welding, accidents are often caused by some unsafe behaviors. This paper focuses on the intelligent recognition method of welding flame, which can reduce the accidents of welding flame to a certain extent. Due to the difficulties in observing workers on job sites, developing an algorithm for intelligent identification of unsafe factors is significant. Firstly, Hue,Saturation and Value (HSV) color space with strong robustness is selected to segment the mark image with threshold value, and the region of interest in which the welding fame is located is segment; secondly, the Progressive Probabilistic Hough transform is used to detect the region of interest, judge the number of existing lines, and finally determine whether there is welding flame in this region. In this way, the welding flame can be better detected, which can reduce the workload of managers and is beneficial to the supervision of the management personnel.