bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychometric evaluation of the traditional Chinese version of the resilience Scale-14 and assessment of resilience in Hong Kong adolescents
Authors: Chung Joyce Oi Kwan , Lam Katherine Ka Wai , Ho Ka Yan , Cheung Ankie Tan , Ho Long Kwan , Xei Viveka Wei , Gibson Faith , Li William Ho Cheung 
Published: February 2020

Abstract
Background
A reliable and valid instrument that accurately measures resilience is crucial for the development of interventions to enhance the resilience of adolescents and promote their positive mental well-being. However, there is a lack of adolescent resilience assessment tools with good psychometric properties suitable for use with Hong Kong participants. This study aimed to evaluate the psychometric properties of the traditional Chinese version of the Resilience Scale-14.

Methods
Between October 2017 and January 2018, a stratified random sample of 1816 Grade 7 (aged 11–15 years) students from all 18 districts of Hong Kong were invited to participate in the study. Subjects were asked to respond to the traditional Chinese version of the Resilience Scale-14, the Center for Epidemiologic Studies Depression Scale for children, and Rosenberg’s Self-Esteem Scale. The psychometric properties, including the internal consistency, content validity, convergent and discriminant validity, exploratory and confirmatory factor analyses, and test–retest reliability of the Resilience Scale-14 were assessed.

Results
The translated scale demonstrated good internal consistency and test–retest reliability, excellent content validity, and appropriate convergent and discriminant validity. The results of the confirmatory factor analysis supported the two-factor structure of the traditional Chinese version of the Resilience Scale-14.

Conclusions
Results suggest that the translated scale is a reliable and valid tool to assess the resilience of young Hong Kong Chinese adolescents. Healthcare professionals could use the newly translated scale to assess resilience levels among Hong Kong adolescents and develop interventions that can help them combat mental health problems and lead healthier lives.

Trial registration
Clinicaltrials.gov ID NCT03538145 (retrospectively registered on May 15, 2018).
ADAMTS13 ameliorates inflammatory responses in experimental autoimmune encephalomyelitis
Authors: Lu Kaili , Liu Lan , Xu Xiaofeng , Zhao Fei , Deng Jiangshan , Tang Xin , Wang Xiuzhe , Zhao Bing-Qiao , Zhang Xiaojie , Zhao Yuwu 
Published: February 2020

Abstract
Background
ADAMTS13 (a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13) plays a vital role in preventing microvascular thrombosis and inflammation. Reduced ADAMTS13 levels in plasma have been detected in multiple sclerosis (MS) patients. In the present study, we have determined the role of ADAMTS13 in the disease progression of MS using a mouse model of experimental autoimmune encephalomyelitis (EAE).

Methods
Female C57BL/6 mice were immunized with MOG35–55 peptide and then treated with ADAMTS13 or vehicle in preventive and therapeutic settings. Mice were analyzed for clinical deficit, white matter demyelination and inflammatory cell infiltration. To explore the underlying mechanism, VWF expression and blood-spinal cord barriers (BSCB) were determined.

Results
Plasma ADAMTS13 activity was suppressed in EAE mice. ADAMTS13-treated EAE mice exhibited an ameliorated disease course, reduced demyelination, and decreased T lymphocyte, neutrophil and monocyte infiltration into the spinal cord. Consistently, ADAMTS13 treatment reduced VWF levels and inhibited BSCB breakdown in the spinal cords of EAE mice. However, leukocytes in the blood and spleen of EAE mice remained unaffected by ADAMTS13 administration.

Conclusion
Our results demonstrate that ADAMTS13 treatment ameliorates inflammatory responses, demyelination and disease course in EAE mice. Therefore, our study suggests that ADAMTS13 may represent a potential therapeutic strategy for MS patients.
A computational model to design neural interfaces for lower-limb sensory neuroprostheses
Authors: Zelechowski Marek , Valle Giacomo , Raspopovic Stanisa 
Published: February 2020

Abstract
Background
Leg amputees suffer the lack of sensory feedback from a prosthesis, which is connected to their low confidence during walking, falls and low mobility. Electrical peripheral nerve stimulation (ePNS) of upper-limb amputee’s residual nerves has shown the ability to restore the sensations from the missing limb via intraneural (TIME) and epineural (FINE) neural interfaces. Physiologically plausible stimulation protocols targeting lower limb sciatic nerve hold promise to induce sensory feedback restoration that should facilitate close-to-natural sensorimotor integration and therefore walking corrections. The sciatic nerve, innervating the foot and lower leg, has very different dimensions in respect to upper-limb nerves. Therefore, there is a need to develop a computational model of its behavior in response to the ePNS.

Methods
We employed a hybrid FEM-NEURON model framework for the development of anatomically correct sciatic nerve model. Based on histological images of two distinct sciatic nerve cross-sections, we reconstructed accurate FEM models for testing neural interfaces. Two different electrode types (based on TIME and FINE) with multiple active sites configurations were tested and evaluated for efficiency (selective recruitment of fascicles). We also investigated different policies of stimulation (monopolar and bipolar), as well as the optimal number of implants. Additionally, we optimized the existing simulation framework significantly reducing the computational load.

Results
The main findings achieved through our modelling study include electrode manufacturing and surgical placement indications, together with beneficial stimulation policy of use. It results that TIME electrodes with 20 active sites are optimal for lower limb and the same number has been obtained for FINE electrodes. To interface the huge sciatic nerve, model indicates that 3 TIMEs is the optimal number of surgically implanted electrodes. Through the bipolar policy of stimulation, all studied configurations were gaining in the efficiency. Also, an indication for the optimized computation is given, which decreased the computation time by 80%.

Conclusions
This computational model suggests the optimal interfaces to use in human subjects with lower limb amputation, their surgical placement and beneficial bipolar policy of stimulation. It will potentially enable the clinical translation of the sensory neuroprosthetics towards the lower limb applications.
Correction to: Effect of vibration characteristics and vibror arrangement on the tactile perception of the upper arm in healthy subjects and upper limb amputees
Authors: Guemann Matthieu , Bouvier Sandra , Halgand Christophe , Paclet Florent , Borrini Leo , Ricard Damien , Lapeyre Eric , Cattaert Daniel , de Rugy Aymar 
Published: February 2020

The original article [1] contained an error whereby the captions to Fig. 3 and Fig. 8 were mistakenly interchanged.
Recent advances in human stem cell-based modeling of Tuberous Sclerosis Complex
Authors: Afshar Saber Wardiya , Sahin Mustafa 
Published: February 2020

AbstractTuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by epilepsy, intellectual disability, and benign tumors of the brain, heart, skin, and kidney. Animal models have contributed to our understanding of normal and abnormal human brain development, but the construction of models that accurately recapitulate a human pathology remains challenging. Recent advances in stem cell biology with the derivation of human-induced pluripotent stem cells (hiPSCs) from somatic cells from patients have opened new avenues to the study of TSC. This approach combined with gene-editing tools such as CRISPR/Cas9 offers the advantage of preserving patient-specific genetic background and the ability to generate isogenic controls by correcting a specific mutation. The patient cell line and the isogenic control can be differentiated into the cell type of interest to model various aspects of TSC. In this review, we discuss the remarkable capacity of these cells to be used as a model for TSC in two- and three-dimensional cultures, the potential variability in iPSC models, and highlight differences between findings reported to date.
Imaging of mandibular fractures: a pictorial review
Authors: Nardi Cosimo , Vignoli Chiara , Pietragalla Michele , Tonelli Paolina , Calistri Linda , Franchi Lorenzo , Preda Lorenzo , Colagrande Stefano 
Published: February 2020

AbstractMandibular fractures are among the most common maxillofacial fractures observed in emergency rooms and are mainly caused by road accidents. The clinical features of mandibular fractures include malocclusion and loss of mandibular function. Panoramic radiography is usually limited to isolated lesions, whereas computed tomography is the tool of choice for all other facial traumatic events. No reference standard classification system for the different types of mandibular fractures is defined. Therapeutic options include a conservative approach or surgical treatment based on the anatomic area and the severity of fracture. The main purpose of this pictorial review is to illustrate a practical description of the pathophysiology of mandibular fractures and describe both the imaging techniques to recognise them and the therapeutic indications.
Transforming growth factor β1 accelerates and enhances in vitro red blood cell formation from hematopoietic stem cells by stimulating mitophagy
Authors: Kuhikar Rutuja , Khan Nikhat , Philip Joseph , Melinkeri Sameer , Kale Vaijayanti , Limaye Lalita 
Published: February 2020

AbstractBackgroundGeneration of red blood cells (RBCs) from hematopoietic stem cells (HSCs) in vitro takes about 21 days, making it unaffordable for clinical applications. Acceleration of the in vitro erythropoiesis process by using small molecules could eventually make the large-scale production of these cells commercially viable. Transforming Growth Factor β1 (TGF-β1) has been shown to have a dose-dependent activity on the HSCs: at high concentration it inhibits, whereas at low concentration it stimulates the HSCs growth. At high concentration, it also inhibits erythropoiesis but accelerates terminal erythroid differentiation of cell lines and erythroid progenitors. Here we examined whether the use of low concentration of TGF-β1 would be beneficial for increasing RBC production by stimulating HSC growth and also supporting erythroid differentiation. Such a strategy could make RBC production in vitro more efficient and cost-effective for clinical applications.MethodsHSCs isolated from Apheresis samples were differentiated into mature RBCs by the sequential addition of specific combinations of growth factors for 21 days. In the control set, only EPO (3 IU/ml) was added whereas, in the test set, TGF-β1 at a concentration of 10 pg/ml was added along with EPO (3 IU/ml) from day 0.ResultsWe found that a low concentration of TGF-β1 has no inhibitory effect on the proliferation of the early stages of erythropoiesis. Additionally, it significantly accelerates terminal stages of erythroid differentiation by promoting BNIP3L/NIX-mediated mitophagy.ConclusionsIncorporation of TGF-β1 at 10 pg/ml concentration in the differentiation medium accelerates the in vitro erythropoiesis process by 3 days. This finding could have potential applications in transfusion medicine.
Periodicity makes perfect: recovering interfered preamble for high-coexistence wireless systems
Authors: Li Ping , Yang Panlong , Yan Yubo 
Published: February 2020

AbstractRecent researches show that cross technology interference management plays an important role in the emergence of innovative applications for nowadays wireless networks. Existing algorithms either suffer from the constraint on the need of clean preamble or require technological similarities among cross technology systems. In this paper, we ask the question: “whether the packet with interfered preamble can be decoded?" To answer this question, we investigate the property of preamble and propose Narthil, an innovative coexistence algorithm which based on imperfect interference management, handling packet detection, symbol synchronization, and channel estimation with interfered preambles. Narthil applies a simple Butterworth band-stop filter for imperfect interference filtering, and leverages the residual signals for packet detection and symbol synchronization, as well as channel estimation. The insight is the inherent properties of preamble such as periodicity and modulation scheme, and the frequency continuity in OFDM signal could be effectively leveraged for important processes such as packet detection, symbol synchronization, and channel estimation. These favorable properties could be used to further enhance the performance of other cross technology signal coexistence algorithms. We implement Narthil algorithm on our USRP/GNU Radio platform, and evaluate its performance by using 15 USRP-N210 devices through the real deployment experiments. The results demonstrate that Narthil can effectively detect the incoming packet and achieves a high accuracy symbol synchronization, as well as channel estimation of the interfered preamble, and also achieve a good performance on packet decoding.
Sedentary behaviour in hospitalised older people: a scoping review protocol
Authors: Jasper Unyime S. , Yadav Lalit , Jadczak Agathe Daria , Yu Solomon , Visvanathan Renuka , Dollard Joanne 
Published: February 2020

AbstractBackgroundOlder adults spend up to 23 h daily sitting or lying while in hospital. Sedentary behaviour (SB) within a hospital setting is often associated with poor health outcomes including physical and cognitive decline, reduced quality of life and death as well as hospital readmissions. Conversely, replacing SB with mild to moderate levels of physical activity such as walking can significantly reduce hospital readmission risk by 30 days. Given the potentially harmful effects of SB in hospitalised older adults, it is vital to identify current literature by broadly exploring different aspects of SB among older people in hospital. The overall aim of this scoping review is to produce a literature map of current evidence on key domains of sedentary behaviour in hospitalised older people.MethodA search for relevant publications will be undertaken in Pedro, MEDLINE Ovid, Cochrane, Scopus, Cumulative Index to Nursing and Allied Health Literature, PsychInfo, Embase, Ageline, Joanna Briggs Institute (JBI) and clinical trials registries. Publications in English and those where the author can provide the full text in English will be included. Studies conducted in hospitals (including in-patient rehabilitation facilities) or acute and subacute care settings and in people aged ≥ 65 will be included. A three-stage method will be used to identify relevant articles, consisting of database search using keywords, keywords and index words across all databases, and reference searching. Articles will be selected following screening of titles/abstracts succeeded by a full-text appraisal utilising a standardised selection form. Two independent reviewers will extract data using the standardised form that will be tested on two articles. A narrative summary will accompany results presented in tables and figures.
How to achieve the climate targets? Spatial planning in the context of the German energy transition
Authors: Wiehe Julia , von Haaren Christina , Walter Anna 
Published: February 2020

Abstract
Background
The transition of the energy system to renewable energy depends on how successfully the national objectives can be implemented at the lower planning levels. Germany pursues an incentive-oriented policy that is not spatially targeted and lets regional and local stakeholders determine where and how renewable energies are used.
A core question is how to achieve the national goals, in a federal system that allows freedom of planning for the local communities. The aim of this paper is to show the discrepancies between the current expansion of wind energy and the necessary expansion that is derived from a scientific analysis.

Methods
The study examined the policy objectives for the expansion of wind energy, based on a literature analysis. In a second step, the regulatory competences and spatial planning at the various levels and their influence on the expansion were explored. In a third step, the current procedure was compared with scientific scenarios of the energy system in 2050 and concretized using the example of the Hannover Region.

Results
The theoretical and empirical analysis shows that people at regional level underestimate their responsibility for contributing to energy transition. The expansion targets for wind energy in the Hannover Region projected in the scientific scenario are above the minimum demand that the local authorities have assumed. The same applies to the state of Lower Saxony, which underestimates its own wind energy potential and thus its necessary contribution to achieving the national targets.

Conclusions
We propose a nationwide coordinated strategy for the successful implementation of the energy transition. With the methodology described, regional targets can be determined and the responsibility of the region and the local actors can be clarified. With the help of spatial planning and public participation, the energy transition can be achieved with this approach.
Carbapenemase-producing Enterobacteriaceae circulating in the Reunion Island, a French territory in the Southwest Indian Ocean
Authors: Miltgen Guillaume , Cholley Pascal , Martak Daniel , Thouverez Michelle , Seraphin Paul , Leclaire Alexandre , Traversier Nicolas , Roquebert Bénédicte , Jaffar-Bandjee Marie-Christine , Lugagne Nathalie , Cimon Céline Ben , Ramiandrisoa Mahery , Picot Sandrine , Lignereux Anne , Masson Geoffrey , Allyn Jérôme , Allou Nicolas , Mavingui Patrick , Belmonte Olivier , Bertrand Xavier , Hocquet Didier 
Published: February 2020

Abstract
Background
The spread of carbapenemase-producing Enterobacteriaceae (CPE) in the Southwest Indian Ocean area (SIOA) is poorly documented. Reunion Island is a French overseas territory located close to Madagascar and connected with Southern Africa, Indian sub-continent and Europe, with several weekly flights. Here we report the results of the CPE surveillance program in Reunion Island over a six-year period.

Methods
All CPE were collected between January 2011 and December 2016. Demographics and clinical data of the carrier patients were collected. We determined their susceptibility to antimicrobials, identified the carbapenemases and ESBL by PCR and sequencing, and explored their genetic relationship using pulsed-field gel electrophoresis and multi-locus sequence typing.

Results
A total of 61 CPEs isolated from 53 patients were retrieved in 6 public or private laboratories of the island. We found that 69.8% of CPE patients were linked to a foreign country of SIOA and that almost half of CPE cases (47.2%) reached the island through a medical evacuation. The annual number of CPE cases strongly increased over the studied period (one case in 2011 vs. 21 cases in 2016). A proportion of 17.5% of CPE isolates were non-susceptible to colistin. blaNDM was the most frequent carbapenemase (79.4%), followed by blaIMI (11.1%), and blaIMP-10 (4.8%). Autochtonous CPE cases (30.2%) harboured CPE isolates belonging to a polyclonal population.

Conclusions
Because the hospital of Reunion Island is the only reference healthcare setting of the SIOA, we can reasonably estimate that its CPE epidemiology reflects that of this area. Mauritius was the main provider of foreign CPE cases (35.5%). We also showed that autochthonous isolates of CPEs are mostly polyclonal, thus unrelated to cross-transmission. This demonstrates the local spread of carbapenemase-encoding genes (i.e. blaNDM) in a polyclonal bacterial population and raises fears that Reunion Island could contribute to the influx of NDM-carbapenemase producers into the French mainland territory.
Perception of quality of life in people experiencing or having experienced a Clostridioides difficile infection: a US population survey
Authors: Lurienne Lise , Bandinelli Pierre-Alain , Galvain Thibaut , Coursel Charles-Alexis , Oneto Caterina , Feuerstadt Paul 
Published: February 2020

Abstract
Background
Although the incidence, severity and mortality of Clostridioides (Clostridium) difficile infection (CDI) have been increasing, patients’ quality of life changes resulting from CDI have not been studied thoroughly. This study aimed at exploring the consequences of CDI on quality of life through patients’ perspective.

Methods
An observational, cross-sectional study involving 350 participants with a self-reported CDI diagnosis was conducted through an online self-administered survey. Participants were grouped into those who had active disease (“Current CDI”) and those who had a history of CDI (“Past CDI”).

Results
One hundred fifteen participants (33%) reported Current CDI and 235 (67%) reported Past CDI. A large majority of participants admitted that their daily activities were impacted by the infection (93.9% and 64.7% of Current and Past CDI respondents respectively, p < 0.05). Physical and psychological consequences of CDI were experienced by 63.5% and 66.1% of participants with active CDI. Despite the infection being cleared, these consequences were still frequently experienced in Past CDI cohort with similar rates (reported by 73.2% of respondents for both, physical consequences p = 0.08; psychological consequences p = 0.21). After the infection, 56.6% of respondents noted that post-CDI symptoms remained; 40.9% believed they would never get rid of them.

Conclusions
While the societal burden of CDI is well described in the literature, our study is one of the first aimed at understanding the major burden of CDI on quality of life. Our results highlight the long-lasting nature of CDI and further reinforce the need for enhanced therapeutics in the prevention and treatment of this devastating infection.