bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of Health-Related Quality of Life in Stroke Survivors After Inpatient rehabilitation
Authors: Rančić Nataša , Mandić Milan , Bogdanović Dragan , Kocić Biljana , Lazarević Konstanca 
Published: December 2019

Abstract
Background. Disordered and decreased quality of life is the most important consequence of stroke for stroke survivors. The aim of the study was to determine the predictors of the health-related quality of life (HRQOL) in stroke survivors six months after discharge from inpatient rehabilitation. Methods. We conducted prospective cohort study which involved 136 (48.5% males and 51.5% females) survivors. We examined seven potential predictors of HRQOL: age, sex, stroke type, stroke side, functional status (Barthel Index-BI and modified Rankin Scale-mRS), cognition (Mini-Mental State Examination; MMSE) and stroke severity (National Institutes of Health Stroke Scale; NIHSS). HRQOL was assessed by Stroke Impact Scale (SIS) 3.0. Using Pearson's correlation and multiple logistic regression analysis we described the relationships between mRS, NIHSS, BI, MMSE and HRQOL. Results. Baseline mRS and NIHSS scores negatively correlated with seven SIS domains except with strength. Baseline BI scores positively correlated with seven SIS domains except mobility and baseline MMSE scores positive correlated with memory, ADL, hand function and participation role and negatively correlated with emotion, communication and mobility domains. Decrease of both mRS and NIHSS scores during the observed period positively correlated with increase of all SIS domains. Ischaemic stroke positively correlated with emotion and communication and stroke in brainstem negatively correlated with communication domain. Memory domain positively correlated with female sex and with stroke in the right hemisphere. Age wasn't significantly associated with any SIS domain. Conclusion. We conclude that major factors in predicting the improvement of strength, physical functioning, mobility, hand function, ADL and participation role were increase of BI and decrease of mRS and NIHSS scores. Female sex, stroke in right hemisphere and increase of BI and MMSE scores predicted better memory. Baseline mRS and NIHSS scores were predictors for improvement of hand function and increase of mRS predicted decrease of hand function and participation role. Key words: stroke, survivors, health-related quality of life, inpatient rehabilitation
A randomised placebo-controlled study into the feasibility and efficacy of working memory training in chronic obstructive pulmonary disease: the study protocol
Authors: Mount Sarah , Houben Katrijn , Gosker Harry , Beers Martijn van , Schuurman Lisanne , Franssen Frits , Janssen Daisy , Schols Annemie 
Published: December 2019

AbstractBackground General cognitive impairment is highly prevalent in patients with chronic obstructive pulmonary disease (COPD). Domain-specific cognitive impairments include deficits in working memory (WM), cognitive flexibility, verbal memory, planning and psychomotor speed. These impairments may be associated with poor health behaviours, such as a sedentary lifestyle and low-quality diet. Cognitive training may reverse these effects. Recent evidence suggests that WM training is linked to self-control and, indirectly, to improved lifestyle behaviour including increased physical activity. We aim to investigate the efficacy of WM training (WMT) in patients with COPD on cognitive performance, cognitive stress susceptibility and perception, self-control, and adherence to personalised physical activity and dietary behaviour goals. Methods A double blind, placebo-controlled randomised trial will be conducted in 60 patients with COPD. The trial will consist of two phases; 12 weeks of active WM training or sham training followed by 12 weeks of maintenance. Prior to the WMT, before the first phase, participants in both the sham (n=30) and training group (n=30) will set dietary and physical activity goals based on their dietary intake and physical activity profile using validated tools. Cognitive performance will be examined using the Cambridge Neuropsychological Test Automated Battery. The primary outcome of this study will be change in cognitive performance. Secondary outcomes will be self-control (impulsivity), compliance, stress susceptibility and perception, change in dietary intake and daily physical activity level and pattern. Discussion This trial will attempt to determine if cognitive performance can be improved in patients with COPD by WMT. Moreover, WM plays a key role in self-regulation of behaviour, i.e. resisting hedonic impulses in exchange for more deliberate evaluations and the achievement of long-term goals. Therefore, we expect that WMT will also have a positive impact on health behaviours. Registration Clinicaltrials.gov registration: NCT03073954, https://clinicaltrials.gov/ct2/show/NCT03073954?term=NCT03073954&rank=1
Platelet count and AST can reliably predict the onset of plasma leakage in dengue, a low-cost triage tool during epidemics
Authors: Medagama Arjuna , Dalugama Chamara , Lakmali Darshani , Meiyalakan Gukes 
Published: December 2019

Abstract
Background:
Dengue is one of the most important mosquito-borne viral infections to affect humans. It is most often a self-limiting febrile illness but in some instances can progress to plasma leakage and in extreme cases culminate in death. The objective of this study was to identify reliable, low-cost, easily-accessible and objective predictors of Dengue hemorrhagic fever (DHF) that can be used as a triage tool in epidemic situations.
Methods
A cohort of dengue fever patients were selected and data on symptoms, clinical signs, routine lab tests, ultrasonography and packed cell volume measurements collected. The demographics and clinical characteristics of severe and non-severe dengue cases were described
Bivariate and regression analysis were used to identify variables significantly correlated with plasma leak.
Results
Serologically confirmed 350 serial adult dengue patients were included in the study. 257 (73.4%) were classified as dengue fever (DF, non leakers) and 93 (26.5%) as DHF with plasma leakage. Bivariate and regression analysis showed platelet count (Pearson r 0.59), and AST (r 0.27) to be significantly correlated with plasma leakage and platelet count to have a moderate predictive association ( R 2 0.35) with plasma leakage. Platelet count <50,000/mm 3 (OR 23.7; 95% CI 12.2-45.9), AST> twice, upper limit of normal (OR 7.5; 95% CI 3.9-14.3) and ALT> twice, upper limit of normal (OR 2.4; 95%CI 1.4-3.6) increased the likelihood of DHF.In the final analysis, logistic regression identified platelet count <50,000/mm 3 (OR 17.2; 95% CI 8.6-34.1) and AST>2ULN (OR 5.1, 95% CI 2.1-12.1) at time of plasma leakage as significant independent predictors of DHF.ROC curve performed for Platelet count had an AUC of .89 and at a platelet count of 50,000/mm 3 predicted DHF with a sensitivity of 87% and specificity of 79%. AUC for AST was 0.72 and at 93Iu/L predicted DHF with a sensitivity of 85% and specificity of 60%.
Conclusion: We have identified 2 laboratory parameters that could be used to identify plasma leakage and might be useful to stratify dengue-infected patients at risk for developing dengue hemorrhagic fever
POWER GENERALIZATION OF CHEBYSHEV’S INEQUALITY – MULTIVARIATE CASE
Authors: Budny Katarzyna 
Published: December 2019

Abstract
In the paper some multivariate power generalizations of Chebyshev’s inequality and their improvements will be presented with extension to a random vector with singular covariance matrix. Moreover, for these generalizations, the cases of the multivariate normal and the multivariate t distributions will be considered. Additionally, some financial application will be presented.
Design of urban runoff pollution control based on the Sponge City concept in a large-scale high-plateau mountainous watershed: a case study in Yunnan, China
Authors: Zhang Zhenyu , Gu Junjie , Zhang Guoshun , Ma Wenjing , Zhao Lei , Ning Ping , Shen Jian 
Published: December 2019

Abstract
China recently commenced the Sponge City initiative for the effective management of urban stormwater runoff. Numerous studies have been carried out to evaluate the cost-effectiveness of low impact development (LID) practices in Sponge City planning and implementation. However, most of the studies were at the site- or subcatchment scale, and few were conducted at the watershed scale, given the dramatically increased routing complexity and number of decision variables. This study demonstrates the cost-effective Sponge City planning process for a 25.90 km2 high-plateau watershed in southwest China. The Stormwater Management Model was coupled with the System for Urban Stormwater Treatment and Analysis Integrated (SUSTAIN) model to perform both continuous simulations and watershed-level optimization analyses, using the reduction of 85% annual runoff volume as the optimization target. Based on over 11,000 optimization runs, a near-optimal aggregated LID scenario was identified for each subcatchment. The aggregated LID size was first converted into a generic LID storage volume for individual subcatchments, and the storage volume was then disaggregated into site-level LID layouts regarding specific site conditions. The disaggregated LID layout yielded an annual average runoff volume reduction of 87.61% and close to 85% reduction for the annual average total suspended solids, total nitrogen, and total phosphorus loads. The systematic approach outlined in this study could be used for watershed-level Sponge City planning and implementation analyses in other cities.
Role of Resveratrol in Modulating microRNAs in Human Diseases: From Cancer to Inflammatory Disorder
Authors: Amiri Atefeh , Mahjoubin-Tehran Maryam , Asemi Zatollah , Shafiee Alimohammad , Hajighadimi Sarah , Moradizarmehri Sanaz , Mirzaei Hamid Reza , Mirzaei Hamed 
Published: December 2019

:
Cancer and inflammatory disorders are two important public health issues worldwide with
significant socio.economic impacts. Despite several efforts, the current therapeutic platforms are
associated with severe limitations. Therefore, developing new therapeutic strategies for the treatment
of these diseases is a top priority. Besides current therapies, the utilization of natural compounds has
emerged as a new horizon for the treatment of cancer and inflammatory disorders as well. Such natural
compounds could be used either alone or in combination with the standard cancer therapeutic modalities
such as chemotherapy, radiotherapy, and immunotherapy. Resveratrol is a polyphenolic compound
that is found in grapes as well as other foods. It has been found that this medicinal agent displays
a wide pharmacological spectrum, including anti-cancer, anti-inflammatory, anti-microbial, and
antioxidant activities. Recently, clinical and pre-clinical studies have highlighted the anti-cancer and
anti-inflammatory effects of resveratrol. Increasing evidence revealed that resveratrol exerts its therapeutic
effects by targeting various cellular and molecular mechanisms. Among cellular and molecular
targets that are modulated by resveratrol, microRNAs (miRNAs) have appeared as key targets. MiRNAs
are short non-coding RNAs that act as epigenetic regulators. These molecules are involved in
many processes that are involved in the initiation and progression of cancer and inflammatory disorders.
Herein, we summarized various miRNAs that are directly/indirectly influenced by resveratrol in
cancer and inflammatory disorders.
Cone Beam CT Evaluation of Maxillary Sinus Floor and Alveolar Crest Anatomy for the Safe Placement of Implants
Authors: Şeker Başak Kuşakçi , Orhan Kaan , Şeker Emre , Ustaoğlu Gülbahar , Ozan Oğuz , Bağiş Nilsun 
Published: December 2019

Background:
Alveolar bone height in the posterior maxillary region is very important
and critical for dental implant planning and placement.

Objective:
This study aimed to evaluate the anatomy of the maxillary sinus floor in relation to the
alveolar crest and to determine variations in the vertical measurements between the maxillary sinus
floor and the alveolar bone crest tip in the posterior edentulous maxilla with the use of cone beam
computerized tomography.

Methods:
This analysis enrolled 234 retrospectively selected patients (123 males with mean age
52.95±11.74 (range 32-76 years) and 111 females with mean age 58.14±11.92 (range 32-75 years))
with edentulous posterior maxillary regions. The maxillary sinus floor was divided into three anatomical
segments (anterior, median and posterior) in relation to the transverse palatine suture. The
measurements were performed on 3D surface rendered volumetric images by using rotation and
translation of the views. Landmarks for measurement were specified by using a cursor driven
pointer. Vertical lines were marked on the cross-sectional images between the alveolar ridge and the
deepest point of the maxillary sinus floor for each of the three regions. P < 0.05 was regarded as
statistically significant.

Results:
The mean distance values between the sinus floor and the alveolar crest in the anterior,
median and posterior regions were 8.74±3.97 mm, 5.37±3.23 mm and 7.06±3.28 mm, respectively.
Measurements in the anterior region were found to be high in both total and gender groups compared
to other regions. Also, subsinus alveolar bone heights decreased with increasing age in both
genders in all three regions.

Conclusion:
This study emphasizes that the mean subsinus alveolar bone height is highest in the
anterior segment of the edentulous posterior maxilla. These results may guide clinicians to make the
decision of implant placement area and lead to less invasive alternative surgery methods for edentulous
posterior segments.
Identification of Key Features of CNS Drugs Based on SVM and Greedy Algorithm
Authors: Zhang Ruilin , Ding Yanrui 
Published: December 2019

Introduction:
The research and development of drugs, related to the central nervous
system (CNS) diseases is a long and arduous process with high cost, long cycle and low success
rate. Identification of key features based on available CNS drugs is of great significance for the
discovery of new drugs.

Methods:
In this paper, based on the PaDEL descriptors of CNS drugs and non-CNS drugs, a support
vector machine (SVM) model was constructed to identify the key features of CNS drugs.
Firstly, the random forest algorithm was used to rank descriptors according to the feature significance
that contributes to the identification of CNS drugs. Then, a reliable SVM model was constructed,
and the optimal combination of descriptors was determined based on greedy algorithm
and recursive feature elimination method.

Results:
It was found, based on the optimal combination of 40 descriptors, the prediction accuracy
of CNS drugs and non-CNS drugs reached 94.2% and 94.4% respectively.

Conclusion:
nF11HeteroRing, AATSC3v, SpMin6_Bhi, maxdssC, AATS4v, E1v, E3e, GATS5s,
minsOH and minHBint4 are the key features to distinguish between CNS drugs and non-CNS drugs.
Is Hepatitis B Surface Antigen (HB s Ag) Enough Alone as a Screening Test for HBV Infection in Rheumatic Disease Patients Before Starting Immunosuppressive Therapies? A Cross-sectional Study
Authors: Abdel-Noor Rasha , Watany Mona , Abd-Elsalam Sherief , ElKhalawany Walaa , Soliman Shaimaa , Badawi Rehab 
Published: December 2019

Background & Objectives:
Prevalence of hepatitis B virus in patients with rheumatic
diseases has been reported differently among studies. The loss of immune control in these patients
may result in the reactivation of HBV replication within hepatocytes. Considering the lifelong use
of multiple anti-rheumatic drugs, screening for HBV is recommended before starting immunosuppressive
or immunomodulatory therapy. The aim of this study was to select the best and simplest
test for screening of HBV in rheumatic patients.

Methods:
This study was carried out in 102 patients with different rheumatic diseases. Screening
to all patients for hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV) antibodies and
human immune deficiency virus antibodies (HIV) was done. HBV core antibodies and real time
PCR to detect HBV DNA were done.

Results:
The mean age of the patients was 37.18 ± 12.37 years, 3.9% of them were males and
96.1% were females. HBsAg had 100% Sensitivity, 100% Specificity, 100% PPV, 100% NPV
and 99.0% accuracy. While, anti-HBc had 100% Sensitivity, 78% Specificity, 8% PPV, 100%
NPV and 78% accuracy in the screening of HBV.

Conclusions:
HBs Ag was found to be superior to antiHBc for screening for HBV infection in
rheumatic patients.
Arthroscopic Standard Anterior and Posteromedial Portal Posterior Cruciate Ligament Reconstruction With Remnant Preservation: 2-Year Follow-up
Authors: Rhatomy Sholahuddin , Saspraditya Erwin , Setyawan Riky 
Published: December 2019

Background:
Grade 3 Posterior Cruciate Ligament (PCL) injury needs surgical intervention, but there is no consensus on the optimal technique in PCL reconstruction. The old technique always removes the remnant for good visualization of tunnel replacement. Recently, many studies proposed the concept of the preservation of PCL remnant with achieving good visualization. The aim of the study is to evaluate PCL reconstruction with remnant preservation using the standard anterior and posteromedial portal at 2-years follow-up.

Methods:
We conducted a cohort retrospective study between January 2013 to December 2015. In this study, 25 patients underwent PCL reconstruction using standard anterior and posteromedial portal with remnant preservation. We used quadrupled hamstring autograft. The patients were assessed using the International Knee Documentation Committee (IKDC) score, Lysholm knee score, Modified Cincinnati Score, and Knee Society Score (KSS) at pre-operative and 2-years post-operative. Range of Motion (ROM) and complication were evaluated post-operatively.

Results:
The mean diameter of the quadruple hamstring graft was 8 mm. Clinical outcomes enhanced significantly (p<0.05). The average Lysholm activity scale improved from 65.12 ± 10.48 to 94.96 ± 4.80. The International Knee Documentation Committee (IKDC) score improved from 60.50 ± 15.10 to 95.60 ± 3.44. The Modified Cincinnati Score improved from 62. 28 ± 13.6 to 96,04 ± 1.62. The KSS also improved from 60.12 ± 18.01 to 94.88 ± 6.36. 22 patients had 0-135° full ROM and 3 patients had 0-110° ROM. Two patients had surgical site infection but recovered with local debridement.

Conclusion:
PCL reconstruction using standard anterior and posteromedial portal with remnant preservation at 2 years follow up resulted in satisfactory clinical and functional outcomes.
Un ejemplo de teatro musical popular novohispano del siglo XVIII. El caso de la tonadilla a solo Los retratos yrónicos
Authors: Vera García Rey Fernando 
Published: December 2019

<p>La tonadilla fue uno de los géneros breves más gustados durante el siglo XVIII en Nueva España. Listas de avalúos y aperos del Coliseo de México muestran una cantidad abrumadora de estas piezas lírico /musicales. Mayoritariamente eran de origen peninsular; sin embargo, algunas de ellas fueron compuestas en el territorio novohispano. El propósito de este trabajo es presentar la transcripción de la letra de una de estas obras: <em>Los retratos irónicos</em>.</p>
Jorge Cañizares-Esguerra (ed.), Entangled Empires. The Anglo-Iberian Atlantic, 1500-1830
Authors: Celaya Nández Yovana 
Published: December 2019

<p>Reseña sobre Jorge Cañizares-Esguerra (ed.), <em>Entangled Empires. The Anglo-Iberian Atlantic, 1500-1830</em>. Philadelphia: University of Pennsylvania Press, 2018.</p>
The Added Effects of Rice Husk Ash Against to Growth and Yield on Basil (Ocimum basilicum)
Authors: Oktaviant Dimas Panji , Purbajanti Endang Dwi , Budiyanto Susilo 
Published: December 2019

Basil is a spice plant that is widely used as a culinary additive, fragrance, atractan, and anti-bacterial because it produces essential oils, basil oil. This research aimed to identifying the affect of adding rice husk ash on different basil’s cultivars on growth and yield of basil (Ocimum basilicum). This research use 4 x 2 factorial experiment pattern with Completely Randomized Design consisting of 5 replication. The first treatment was various type of basil’s cultivars such as Genovese cultivars (K1) and Dark Opal cultivars (K2). The second treatment was doses of rice husk ash such as control or without giving rice husk ash (M0), 30 g/pot (M1), 35 g/pot (M2), dan 40 g/pot (M3). The observed parameters were soil bulk density and porosity, plant height, leaves total, roots length, and leaves simplisia. The results showed that the application of husk ash can affect the increase in physical properties of the soil, but has not directly affected the growth parameters and yield of leaf simplisia. Dark Opal cultivars on all growth parameters showed higher yields, but Genovese cultivars showed higher yields or simplisia.
ESTRATEGIAS DE MERCADEO IMPLEMENTADAS POR LAS EMPRESAS DE SERVICIOS DE LA GRAN ÁREA METROPOLITANA EN COSTA RICA
Authors: Hernández Mainieri Ana , Mora Miranda Geiner 
Published: December 2019

El mercadeo, al igual que muchas áreas del conocimiento humano, ha venido evolucionando a lo largo de los años en la búsqueda de mejores estrategias que contribuyan eficientemente con el logro de los objetivos organizacionales. La gestión mercadológica dentro del quehacer empresarial, exige mayor conocimiento por parte de los administradores, de manera que se posibilite la implementación de estrategias más eficientes.
En este caso, se analiza el modo en que los administradores de servicios de algunas empresas de diversos sectores de la Gran Área Metropolitana costarricense dicen emplear los elementos de las 4 C en sus organizaciones Por lo anterior, se realiza la revisión cualitativa de las estrategias mercadológicas que emplean quince empresas de servicios de la Gran Área Metropolitana, a la luz de la estrategia recomendado por Cobra (2000), conocida como 4 C, y, con base en ello, se realiza una propuesta para ser empleada por las empresas costarricenses en forma funcional.
PRINCIPALES FACTORES DE ÉXITO EN EL ÁMBITO DE LA ADMINISTRACIÓN PÚBLICA
Authors: Fong Jiménez Yelitza 
Published: December 2019

Este trabajo se basa en la metodología de sistematización de experiencias a partir de un enfoque cualitativo, cuyo fin es contribuir a la generación de conocimiento para el análisis y discusión de una cuestión fundamental: la gestión pública.
La propuesta parte del intercambio académico a nivel de organizaciones de América Latina, en el cual se comparten las vivencias que permiten enriquecer la discusión teórica y, con mirada crítica, abordar su aplicabilidad en la cotidianeidad laboral.
Se describe los principales factores de éxito para lograr un mejor desempeño dentro del ámbito de la administración pública. La gestión institucional se ve fortalecida por medio de una reflexión constante con el quehacer individual que aporta a su vez valor agregado al bienestar colectivo. Se aporta una visión general que abarca el conocimiento de los elementos del contexto internacional y nacional, analizando las buenas prácticas de la nueva gestión pública.