bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of the pattern, intent behind and outcome of acute poisoning in a tertiary care centre
Authors: Srinivas G. , Aashik Y. S. , Muthalik Manoj 
Published: December 2020

Background: Acute poisoning is one of the major medical emergencies with significant morbidity and mortality. Appropriate planning, prevention and management techniques can be designed by knowing the nature, severity and outcome of acute poisoning cases. Most of the poisoning is due to the intention of deliberate self-harm. This study aimed to study the pattern and outcome of acute poisoning and the intent behind poisoning. Methods: This is a cross sectional study which included 100 acute poisoning cases in a tertiary care hospital. The study includes data regarding age, sex, time elapsed after intake of poison; name of the poisonous substance, duration of hospitalization, severity and outcome were collected in the prestructured proforma. Intent behind poisoning was calculated using Beck’s suicide intent score. Results: Incidence was more common among males (69%) but there was no significant correlation between gender and mortality. Mean age of presentation was 35.66 years but age of presentation and mortality correlation was not statistically significant (t=0.92, p=0.3). Organophosphorous compound poisoning (36%) was the most common type of poisoning. Total mortality was found to be 12%. Beck’s suicide intent scores were higher in patients who died and statistically significant (t=8.96, p=0.0001). Maximum patients expired when there was a delay in admission to hospital by more than 8 hours after exposure. Conclusions: Poisoning is more common in young males. The overall mortality depends on type of poison, time elapsed since exposure to hospital arrival, suicidal intent and many other factors. Early care in a tertiary care center may help to reduce mortality in India.
Pseudo scapula alata: a case report of a scapular osteochondroma
Authors: Sousa Rita M. , Sapage Rita , Branco Carlos , Sousa Diogo , Reis Joao , Geraldes Ricardo , Branco Ricardo , Cruz António Gomes 
Published: December 2020

<p class="abstract">An osteochondroma is a type of cartilaginous tumour, that frequently affects long bones. In the scapula, although rare, this benign tumour is the most frequently encountered. The symptoms at this location are usually related to the mass effect that it can produce. Surgery is recommended when symptoms of compression, pain or an increase in size are noticed. The authors present a case of a 11 year-old-boy with an osteochondroma on the ventral surface of the scapula, that cause a pseudo winging of this bone and pain, with indication for surgical excision. Pseudo scapula alata should be differentiated from the true one, which is a dynamic dyskinesia. In the presence of this static deformity the surgeon must keep in mind other diagnosis as a scapular osteochondroma or other mass effect lesions. This benign tumour does not frequently suffer malignant transformation. Surgery can lead to a complete resolution of the symptoms, and if done properly decrease to almost zero the rate of recurrence. The diagnosis of the tumour in this location can be delayed due to its atypical location and presentation. With this case report the authors expect to raise awareness of the unusual manifestations of osteochondroma, especially in the paediatric setting.</p><p class="abstract"> </p>
Contrasting presentation of solitary scapular osteochondroma: a report of three cases and review of literature
Authors: Varughese Ajay Alex , Pandey Ritesh Arvind , Paul Rajesh , John Bobby 
Published: December 2020

<p class="abstract">Scapular osteochondroma can have unusual manifestations like pseudo-winging and snapping syndrome in ventrally located lesions. Dorsally located lesions cause a cosmetic blemish and difficulty in lying supine. We present a series of 3 cases of scapular osteochondroma with varying presentations. One was a ventral surface (subscapular) osteochondroma which presented with pseudo winging and snapping syndrome and 2 were dorsal surface osteochondromas which presented with prominence at the back and difficulty in lying supine. All were treated surgically with good functional and cosmetic results. Surgical resection of tumor is the treatment of choice. An appropriate surgical approach should be chosen depending on the location of tumor. We propose the use of trapezius sparing approach and splitting the scapular apophysis for subscapular osteochondroma in children as it produces less soft tissue damage, is easy to repair and allows early rehabilitation.</p><p class="abstract"> </p>
Un etnomusicólogo en «escucha» (kûrûchobea) con los emberá chamí: una performance chamánica en los Andes
Authors: Molano Zuluaga Juan Carlos 
Published: December 2020

Este artículo se enmarca desde una provocación de carácter teóricometodológico basado en la experiencia intercultural de audición que tuvo en la década de 1970 el antropólogo colombiano Luis Guillermo Vasco con las prácticas chamánicas de los emberá chamí. Este lineamiento permite determinar algunos cuestionamientos con respecto a la posicionalidad en campo de este antropólogo en lo que respecta a la escucha, como un oído que atendió y tradujo ciertas significaciones auditivas a ciertos parámetros culturales. Ahora bien, estas interpretaciones etnomusicológicas, están dadas a partir de estas directrices y confrontadas por la inserción y participación en campo en un evento de «toma» o ingesta de ayahuasca en el resguardo indígena emberá chamí de San Lorenzo. La discusión ahonda en la imaginación y conceptualización indígena sobre el sonido, que merece especial atención en la etnomusicología/antropología auditiva y que podría problematizar algunas teorías, como por ejemplo el perspectivismo amerindio. Sin embargo, la intención acá y basada en esa concedida intersubjetividad en el territorio indígena, es provocar consideraciones en torno a un concepto ontológico que llamaría «percepcionismo sónico», que es atribuido, como su nombre lo indica, a las percepciones de un determinado paisaje sonoro y su intangibilidad de territorio(s) y que podría complementar la teoría perspectivista que cimenta sus interpretaciones en una corporalidad tangible definida solo por su visibilidad.
A Note on Multiset Dimension and Local Multiset Dimension of Graphs
Authors: Alfarisi Ridho , Lin Yuqing , Ryan Joe , Dafik Dafik , Agustin Ika Hesti 
Published: December 2020

All graphs in this paper are nontrivial and connected simple graphs. For a set W = {s1,s2,...,sk} of verticesof G, the multiset representation of a vertex v of G with respect to W is r(v|W) = {d(v,s1),d(v,s2),...,d(v,sk)} whered(v,si) is the distance between of v and si. If the representation r(v|W)̸= r(u|W) for every pair of vertices u,v of a graph G, the W is called the resolving set of G, and the cardinality of a minimum resolving set is called the multiset dimension, denoted by md(G). A set W is a local resolving set of G if r(v|W) ̸= r(u|W) for every pair of adjacent vertices u,v of a graph G. The cardinality of a minimum local resolving set W is called local multiset dimension, denoted by µl(G). In our paper, we discuss the relationship between the multiset dimension and local multiset dimension of graphs and establish bounds of local multiset dimension for some families of graph.
Metode Pendidikan Ahlak Anak Usia Dini dan Relevansinya Terhadap Pendidikan Nasional
Authors: Sanusi Ahmadsanusi 
Published: December 2020

This research is a research-based on library research (Library Research). The progress and sophistication of the times and technology have resulted in many children falling into the abyss of error resulting in moral decadence such as brawls between students, promiscuity, consuming drugs, free sex, and so on. Based on this problem, it is certainly a responsibility for all elements, especially parents and educators to provide the right solution for the next generation of this nation. On that basis, the focus and purpose of this study are to explain the method of moral education according to Imam Al-Ghazali and Abdullah Nashih Ulwan. The relevance of moral education between the two figures' thoughts and the national education system is clearly seen in the definition of education itself, the aims of education, and the educational methods used.
Improving Management of Adult Ankle Fractures in Malawi
Authors: Agarwal-Harding Kiran J. , Kapadia Ami , Banza Leonard Ngoie , Chawinga Mabvuto , Mkandawire Nyengo , Kwon John Y. 
Published: December 2020

Background:
The burden of musculoskeletal trauma is increasing worldwide, especially in low-income countries such as Malawi. Ankle fractures are common in Malawi and may receive suboptimal treatment due to inadequate surgical capacity and limited provider knowledge of evidence-based treatment guidelines.

Methods:
This study was conducted in 3 phases. First, we assessed Malawian orthopaedic providers’ understanding of anatomy, injury identification, and treatment methods. Second, we observed Malawian providers’ treatment strategies for adults with ankle fractures presenting to a central hospital. These patients’ radiographs underwent blinded, post hoc review by 3 U.S.-based orthopaedic surgeons and a Malawian orthopaedic surgeon, whose treatment recommendations were compared with actual treatments rendered by Malawian providers. Third, an educational course addressing knowledge deficits was implemented. We assessed post-course knowledge and introduced a standardized management protocol, specific to the Malawian context.

Results:
In Phase 1, deficits in injury identification, ideal treatment practices, and treatment standardization were identified. In Phase 2, 17 (35%) of 49 patients met operative criteria but did not undergo a surgical procedure, mainly because of resource limitations and provider failure to recognize unstable injuries. In Phase 3, 51 (84%) of 61 participants improved their overall performance between the pre-course and post-course assessments. Participants answered a mean of 32.4 (66%) of 49 questions correctly pre-course and 37.7 (77%) of 49 questions correctly post-course, a significant improvement of 5.2 more questions (95% confidence interval [CI], 3.8 to 6.6 questions; p < 0.001) answered correctly. Providers were able to identify 1 more injury correctly of 8 injuries (mean, 1.1 questions [95% CI, 0.6 to 1.6 questions]; p < 0.001) and to identify 1 more ideal treatment of the 7 that were tested (mean, 1.0 question [95% CI, 0.5 to 1.4 questions]; p < 0.001).

Conclusions:
Adult ankle fractures in Malawi were predominantly treated nonoperatively despite often meeting evidence-based criteria for surgery. This was due to resource limitations, knowledge deficits, and lack of treatment standardization. We demonstrated a comprehensive approach to examining the challenges of providing adequate orthopaedic care in a resource-limited setting and the successful implementation of an educational intervention to improve care delivery. This approach can be adapted for other conditions to improve orthopaedic care in low-resource settings.
Comparison of Intravenous and Periarticular Administration of Corticosteroids in Total Knee Arthroplasty
Authors: Hatayama Kazuhisa , Terauchi Masanori , Oshima Atsufumi , Kakiage Hibiki , Ikeda Keiko , Higuchi Hiroshi 
Published: December 2020

Background:
Corticosteroids are widely used in total knee arthroplasty (TKA) to relieve postoperative pain and prevent postoperative nausea. The aim of this prospective, randomized controlled study was to compare the effects of intravenous and periarticular administration of corticosteroids on pain control, prevention of postoperative nausea, and inflammation and thromboembolism markers following TKA.

Methods:
One hundred patients undergoing TKA were randomly allocated to either the intravenous administration or periarticular injection group. The intravenous administration group received 10 mg dexamethasone 1 hour before and 24 hours after the surgical procedure, as well as a periarticular injection placebo during the procedure. The periarticular injection group received a 40-mg injection of triamcinolone acetonide during the surgical procedure, as well as an intravenous administration placebo 1 hour before and 24 hours after the procedure. Postoperative pain scores at rest and during walking and nausea scores were recorded according to the 0-to-10 Numerical Rating Scale. Interleukin-6 (IL-6), C-reactive protein (CRP), and prothrombin fragment 1.2 (PF1.2) were measured preoperatively and postoperatively.

Results:
Pain scores at rest and during walking 24 hours postoperatively were significantly lower in the periarticular injection group than in the intravenous administration group. Nausea scores showed no significant difference between groups. IL-6 at 24 and 48 hours postoperatively also showed no significant difference between groups. CRP at 24 and 48 hours postoperatively was significantly lower in the intravenous administration group than in the periarticular injection group. In contrast, CRP at 1 week postoperatively was significantly higher in the intravenous administration group than in the periarticular injection group. The mean PF1.2 was significantly lower in the intravenous administration group than in the periarticular injection group at 4 hours postoperatively. Two cases of deep venous thrombosis in each group were detected with use of ultrasonographic examination.

Conclusions:
Periarticular injection of corticosteroids showed a better pain-control effect at 24 hours postoperatively than did intravenous administration, whereas the antiemetic effect was similar between treatments. Although intravenous administration had a better anti-thromboembolic effect than periarticular injection, the incidence of deep venous thrombosis was low in both groups.

Level of Evidence:
Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
Traumatic Posterior Hip Dislocation and Epiphysiolysis in a High School Football Player with Successful Outcome at 4 Years Follow-up
Authors: Nazareth Alexander , Cooper Benjamin , Hollenbeck Steven Matt 
Published: December 2020

Case:
We describe a case of posterior hip dislocation in a 13-year-old boy after a contact football injury with attempted closed reduction resulting in complete separation of the epiphysis from the femoral neck metaphysis with associated femoral head fracture and posterior dislocation of the femoral head. Treatment was emergently performed with a greater trochanteric osteotomy, open reduction internal fixation using cannulated screws, and additional small diameter drill holes in the femoral head to promote blood flow. The patient did well postoperatively and at over 4 years follow-up had no evidence of avascular necrosis and returned to full athletics participation.

Conclusion:
Particular attention should be taken when reducing hip dislocations in the adolescent population who may be predisposed to epiphysiolysis. Preservation of periosteal soft-tissue attachments and the use of small diameter drill holes to promote femoral head blood flow may have contributed to the excellent outcome.
Anterior Capsular Reconstruction with Dermal Allograft in Combination With Anatomic Glenohumeral Arthroplasty
Authors: Bernstein Derek T. , Kluemper Chase T. , Kearns Kenneth A. 
Published: December 2020

Case:
A 43-year-old man with chronic right shoulder pain and dysfunction due to recurrent anterior instability, irreparable subscapularis tear, and glenohumeral arthritis presented to our practice. After workup and counseling, he was treated with anatomic total shoulder arthroplasty augmented by anterior capsular reconstruction using human acellular dermal allograft. At 15 months postoperatively, his forward elevation, external rotation, and internal rotation were 160, 45, and T12, nearly equal to contralateral values. His glenohumeral joint remained reduced, and no complications were encountered.

Conclusion:
We report the first known anterior capsular reconstruction performed in combination with anatomic shoulder arthroplasty.
Concomitant Dislocation of the Hallucal Interphalangeal Joint and Extra-Articular Dislocation of Its Sesamoid
Authors: Lynch-Wong Matthew , Hashem Feras , Al-Baqali Mohammed , Wong-Chung John 
Published: December 2020

Case:
A 22-year-old man sustained closed dislocation of the hallucal interphalangeal joint (HIPJ). Painful limitation of movements persisted 2 months after closed reduction. Magnetic resonance imaging revealed dislocation of the hallucal interphalangeal joint sesamoid (HIPJS) from its intra-articular attachment on the superior surface of the plantar plate to an extra-articular subcutaneous location, plantar and lateral to the flexor hallucis longus tendon. The HIPJS was enucleated through a plantar approach, and the foot remains pain-free 18 months later.

Conclusions:
This case represents an unusual combination of HIPJ dislocation and extra-articular dislocation of its sesamoid. Raised awareness of the HIPJS, its normal anatomical location, and configuration will avoid delayed diagnosis.
In Silico Studies Reveal Antiviral Effects of Traditional Indian Spices on COVID-19
Authors: Kumar Brijesh , Zaidi Sama , Haque Shafiul , Dasgupta Nandita , Hussain Arif , Pramodh Sreepoorna , Singh Vineeta , Mishra Bhartendu N. 
Published: December 2020

Background:
The global health emergency due to SARS-CoV-2 causing the COVID-19 pandemic
emphasized the scientific community to intensify their research work for its therapeutic solution. In this study,
Indian traditional spices owing to various medicinal properties were tested in silico for their inhibitory activity
against SARS-CoV-2 proteins. SARS-CoV-2 spike proteins (SP) and main proteases (Mpro) play a significant
role in infection development were considered as potential drug targets.

Methods:
A total of 75 phytochemicals present in traditional Indian spices retrieved from the published literature
and Dr. Duke’s Phytochemical and Ethnobotanical Database, were docked with Mpro (PDB IDs: 6YNQ),
and the SP (PDB IDs: 6LXT and 6YOR).

Results:
Through the screening process, 75 retrieved phytochemicals were docked with spike protein (PDB
IDs: 6LXT and 6YOR) and main protease (PDB ID: 6YNQ) of SARS-CoV-2. Among them, myricetin, a flavonoid
(rank score: 6LXT: -11.72383; 6YOR: -9.87943; 6YNQ: -11.68164) from Allium sativum L and Isovitexin,
an example of flavone (rank score: 6LXT: -12.14922; 6YOR: -10.19443; 6YNQ: -12.60603) from Pimpinella
anisumL were the most potent ligands against SP and Mpro of SARS-CoV-2. Whereas, Astragalin from Crocus
sativus L.; Rutin from Illicium verum, Oxyguttiferone from Garcinia cambogia; Scopolin from Apium
graveolens L, Luteolin from Salvia officinalis, Emodin, Aloe-emodin from Cinnamomum zeylanicium and
Apigenin from Allium sativum L showed better inhibition against Mpro than SP of SARS-CoV-2. The amino acid
residues like SER, LYS, ASP and TYR were found playing important role in protein-ligand interactions via
hydrogen bonding and Vander Waals forces.

Conclusion:
Optimal use of traditional spices in our daily meals may help fight against COVID-19. This study
also paves the path for herbal drug formulation against SARS-CoV-2 after wet lab validation.
Machine Learning-Based Virtual Screening Strategy RevealsSome Natural Compounds as Potential PAK4 Inhibitors in Triple Negative Breast Cancer
Authors: Iwaloye Opeyemi , Elekofehinti Olusola O. , Kikiowo Babatomiwa , Oluwarotimi Emmanuel A. , Fadipe Toyin M. 
Published: December 2020

Background:
P-21 activating kinase 4 (PAK4) is implicated in the poor prognosis of
many cancers, especially in the progression of Triple Negative Breast Cancer (TNBC). The present
study was aimed at designing some potential drug candidates as PAK4 inhibitors for breast cancer
therapy.

Objective:
This study aimed to finding novel inhibitors of PAK4 from natural compounds using
computational approach.

Methods:
An e-pharmacophore model was developed from docked PAK4-co-ligand complex and
used to screen over a thousand natural compounds downloaded from BIOFACQUIM and NPASS
databases to match a minimum of 5 sites for selected (ADDDHRR) hypothesis. The robustness of
the virtual screening method was accessed by well-established methods including EF, ROC, BEDROC,
AUAC, and the RIE. Compounds with fitness score greater than one were filtered by applying
molecular docking (HTVS, SP, XP and Induced fit docking) and ADME prediction. Using Machine
learning-based approach QSAR model was generated using Automated QSAR. The computed
top model kpls_des_17 (R2= 0.8028, RMSE = 0.4884 and Q2 = 0.7661) was used to predict the
pIC50 of the lead compounds. Internal and external validations were accessed to determine the predictive
quality of the model. Finally, the binding free energy calculation was computed.

Results:
The robustness/predictive quality of the models was affirmed. The hits had better binding
affinity than the reference drug and interacted with key amino acids for PAK4 inhibition. Overall,
the present analysis yielded three potential inhibitors that are predicted to bind with PAK4 better
than the reference drug tamoxifen. The three potent novel inhibitors, vitexin, emodin and ziganein
recorded IFD score of -621.97 kcal/mol, -616.31 kcal/mol and -614.95 kcal/mol, respectively while
showing moderation for ADME properties and inhibition constant.

Conclusion:
It is expected that the findings reported in this study may provide insight for designing
effective and less toxic PAK4 inhibitors for triple negative breast cancer.
Thoughts of Death, Depression and Guilt in a Healthcare Worker Who Infected Her Husband with SARS-CoV-2: A Case Report
Authors: Berardelli Isabella , Vaia Antonio , Pompili Maurizio 
Published: December 2020

Background:
The worldwide spread of the novel coronavirus (SARS-CoV-2) has exposed
healthcare workers (HCWs) to physical and mental disorders both directly and indirectly related
to the pandemic. Italy was the first European country affected by the SARS-CoV-2 pandemic,
and Italian HCWs have presented adverse psychological outcomes related to work and emotional
overload and the fears of becoming infected and infecting others, particularly loved ones.

Case Presentation:
We report the case of a 61-year-old HCW who likely infected her husband
with SARS-CoV-2, leading to his death. We assessed the depressive and anxious symptoms that
the patient experienced after the death of her husband, which were characterized by a deep sense of
guilt, psychological pain, and thoughts of death.

Conclusion:
In our opinion, our case emphasizes the fact that HCWs need greater mental health assistance,
particularly those who are heavily involved in the care of patients and who have possible
risk factors for psychiatric symptoms.