bluuebunny/crossref_metadata_2025_split huggingface dataset:
ISOLATION OF ACTINOMYCETES FROM THE SEDIMENTS OF PICHAVARAM MANGROVE FOREST, SOUTH INDIA AND ANALYSING THEIR ANTIBACTERIAL EFFICACY
Authors: M AARTHI , D KAMALANATHAN , V BALAKRISHNAN 
Published: May 2020

Objective: The aim of the present investigation is to isolate actinomycetes from the sediments of Pichavaram mangrove forest, South India, and to screen for their antibacterial efficiency.
Methods: Actinomycetes were isolated by culturing the samples in Starch Casein Agar medium; they were screened primarily for their antibacterial efficiency against Gram-positive and Gram-negative bacterial organisms. Solvent extraction was done with 50% (percentage) ethyl acetate, crude extracts of actinomycetes were prepared at different concentrations using dimethyl sulfoxide and treated against the bacterial organisms. Antibacterial assay was done in Mueller–Hinton agar medium.
Results: Thirteen actinomycetes were isolated; among them, four actinomycete isolates (Pichavaram mangrove actinomycete 2 [PMA2], PMA6, PMA9, and PMA13) exhibited antibacterial activity.
Conclusion: Isolate PMA2 exhibited very strong antibacterial activity and isolate PMA13 is weakly active against the tested bacterial organisms.
PREVALENCE OF 25-HYDROXY VITAMIN D DEFICIENCY AND SOME BIOCHEMICAL PARAMETERS IN IRAQI PATIENTS WITH RHEUMATOID ARTHRITIS AND THEIR ASSOCIATIONS WITH DISEASE ACTIVITY
Authors: AL-GEBORI ABDULNASSER M , MUNSHED ALOSAMI MOHAMMED HADI , AL-HASHIMI NAWAL HAIDER 
Published: May 2020

Objectives: The objectives of the study were to evaluate changes in 25(OH) Vitamin D levels and some biochemical parameters in rheumatoid arthritis (RA) patients compared with healthy controls and assess the correlation of 25-hydroxy Vitamin D, calcium, magnesium, and disease activity. Study the effects of anti-RA drugs on these biochemical parameters and also the role of supplements calcium and 25-OH Vitamin D in RA patients.
Methods: This study conducted between 60 patients for RA and 20 healthy controls according to the American College of Rheumatology standards in 2010. In this study, 25-hydroxy Vitamin D was measured using an enzyme-linked immunosorbent assay, and also some biochemical parameters were measured with a spectrophotometer (Humalyzer 2000).
Results: Serum 25(OH) Vitamin D, calcium, magnesium, and albumin levels were significantly lower in RA patients compared with healthy controls. Serum alanine aminotransferase aspartate aminotransferase levels were significantly increased in RA patients compared with healthy controls. The correlation was non-significantly among 25-hydroxy Vitamin D and clinical disease activity index (CDAI), while the results showed significantly inverse correlation calcium and magnesium concentrations with CDAI.
Conclusion: 25-OH Vitamin D, calcium, albumin, and magnesium deficiency appear to be widespread in patients with RA. Thus, biochemical changes in RA are reflected in the pathogenesis of RA. Furthermore, in these results, there is no relationship between Vitamin D and the disease activity, while there is a relationship between calcium and magnesium with disease activity.
AN OBSERVATIONAL STUDY OF CLINICAL AND HEMATOLOGICAL PROFILE OF CIRRHOSIS OF LIVER
Authors: BEHERA BIBHU PRASAD , Dash Manoranjan 
Published: May 2020

Objective: Efforts can be made to normalize the hematological parameters so that the morbidity and mortality in these patients could be effectively reduced.
Methods: This observational study was carried out among 69 cirrhosis patients that fulfills the inclusion and exclusion criteria, attended the medicine outpatient department, and admitted in medicine ward of PRM Medical College and Hospital, Baripada, Dist. Mayurbhanj, Odisha, India, from June 2018 to January 2019.
Results: In our study, we had 59 male and 10 female patients with an average age of 49.8±13.19 years. About 92.75% of the patients were alcoholic. Abdominal distension (92.75%) and ascites (84.06%) were the most common presenting complaints. Pallor was present in 42 (60.87%) cases. Splenomegaly was present in 35 (50.72%) cirrhotic patients. Renal dysfunction was present in 23 (33.33%) cases. Sixty-six (95.65%) patients had anemia and 47 (68.12%) patients had thrombocytopenia.
Conclusions: From this study, we can conclude that, in cirrhosis of liver patients, various hematological changes are very common which need to be identified and corrected early to reduce morbidity and mortality.
REVERSAL OF CISPLATIN-INDUCED MEMORY IMPAIRMENT BY GALLIC ACID IN EXPERIMENTAL RAT MODEL
Authors: Patel Sucharita , HM Chandan , KL Krishna , HS Nandini , Ghosh Abhinav Raj , AN Bhooshitha 
Published: May 2020

Objective: The objective of the study was to evaluate the protective effect of gallic acid on cisplatin-induced memory impairment (MI) in the rat model.
Methods: Five groups of Wistar albino rats (n=6) were employed and the duration of the study was 22 days, excluding the pre-treatment period. Animals were pretreated with gallic acid for a period of 5 days and continued daily (200 mg/kg) for 22 days. The cisplatin (3 mg/kg) was given once in a week for 3 consecutive weeks to induce MI, whereas donepezil was used as standard. The evaluation was done by a change in body weight, memory activity by Morris water maze (MWM), locomotor activity by actophotometer, antioxidant activity by thiobarbituric acid reactive substance (TBARS), glutathione (GSH), and estimation of acetylcholinesterase (AChE) activity in brain homogenate.
Results: Administration of cisplatin has induced MI by increasing in escape latency time, decrease in time spent in the target quadrant in the MWM task and it was reversed by gallic acid treatment. Decreased locomotor activity by cisplatin was also increased by gallic acid when tested by actophotometer. Cisplatin administration has induced oxidative stress by increasing TBARS and decreasing GSH levels. Gallic acid due to its proven antioxidant activity reversed the effects of cisplatin. The AChE level was significantly increased in the control group, whereas treatment groups have shown a decrease in AChE level.
Conclusion: Gallic acid may serve as a primary agent to treat the cognitive impairment and oxidative stress associated memory dysfunctions. However, more extensive studies are needed before utilization in the clinical trial.
OPTIMIZATION OF DRUG SOLUBILITY USING ASPEN PLUS: ACETYLSALICYLIC ACID (ASPIRIN) SOLUBILITY – A SECOND CASE STUDY
Authors: AL-MALAH KAMAL I 
Published: May 2020

Objective: The objective of the study is to optimize the solubility of a drug or a drug-like molecule using Aspen Plus simulation platform. Aspirin (solute) was taken as the second case study. The following solvents were used in our dry (virtual) laboratory experiment: Water, acetone, ethanol, and ethylene-glycol-mono-propyl-ether (PROPGLYC).
Methods: A simplified process flow sheet made of a single mixing tank where it has five feed streams, representing the solute, the water, and the set of three organic solvents, and one product stream where aspirin is either solubilized (liquid solution) or remains as solid crystal. Minimization of the molar Gibbs free energy of mixing, ΔGmix, was used as an objective function from an optimization point of view. The Non-random Two-liquid property method was used to analyze the solution properties.
Results: Using the molar Gibbs free energy of mixing, ΔGmix, as a criterion of solution thermodynamic stability, it was found that the most stable solution is the quinary mixture made of 24.42% aspirin, 10.22% water, 21.08% acetone, 19.51% ethanol, and 24.77 mole % PROPGLYC.
Conclusions: Exploiting Aspen Plus can be extended to handle the solubility of a new drug-like molecule once it is defined within its molecular editor with a little knowledge such as density and/or melting point.
EFFECTIVE MANAGEMENT OF ODONTOGENIC INFECTIONS THROUGH CONTROLLED FASHION BY POLYMERIC DEVICE CONTAINING MOXYFLOXACIN
Authors: P. Gorle A. , V. Mahale H. , S. Patil C. 
Published: May 2020

Objective: Present work demonstrates the use of film that releases the drug at a pre-programmed manner. Several methods have been explored for management of moxifloxacin in dealing of Odontogenic infections which are mainly caused by necrotic pulp or by bacterial invasion from the periodontal tissue. These are usually mixed bacterial infections, and they penetrate mostly into the soft and bony oromaxillofacial tissues to produce submucosal infiltrates and abscesses.Methods: The films were developed with the intention to minimize the dose of a drug, to deliver definite concentration and to preserve dosage at its site for a longer period by this means gets a better patient compliance. Moxifloxacin films were prepared by solvent casting technique using gellan gumÂ at different concentrations and PEG 400 as plasticizers. Compatibility study such as FT-IR and DSC also performed to check the interaction between drug and excipients used. The formulations were evaluated for their thickness, weight uniformity, folding endurance, content uniformity, surface pH, In vitro drug release. Optimized formulations were subjected to in vitro antibacterial activity and stability studies to assess the effectiveness of the formulations.Results: Formulations shown the good uniformity of drug content, there was no any kind of effect on moisture loss test. Weight and thickness of the films were found to be uniform. Plasticizer like PEG400 was found to influence their effect on drug release as well as characteristics of films.Conclusion: In vitro studies revealed that the formulations provide the best alternative to prolong drug release at the end of 10 h and formulations remained stable with intact at ambient conditions.Â
PHARMACOLOGICAL EVALUATION OF ANTIANXIETY ACTIVITY OF DESMOSTACHYA BIPINNATA LEAVES IN ANIMAL MODELS
Authors: I. Veena Rani , G. Kiranmai , Pulla Ravi Pratap 
Published: May 2020

Objective: Anxiety is a widespread psychiatric disorder affecting around 5% of the population. Furthermore, it is difficult to predict patientâ€™s response to any given treatment. In the traditional systems of medicine, many plants have been used to treat anxiety and depression for thousands of years. Desmostachyabipinnata belongs to the family Poaceae, have pharmacological actions like dysenteryÂ andÂ menorrhagia, and as aÂ diuretic. The present study was designed to evaluate the antianxiety activity of the alcoholic and aqueous extracts of Desmostachyabipinnata leaves in rodents.Methods: Antianxiety activity was screened by different methods like elevated plus maze model and actophotometer.Results: The results infer that reduced aversion fear elicits anti-anxiety activity.Conclusion: It was concluded that alcoholic and aqueous extracts of Desmostachyabipinnata leaves are having anti-anxiety activity among which alcoholic extract of Desmostachyabipinnata leaves showing more significant activity over the aqueous extract.Â
Peranan Bendesa dalam Penyelesaian Sengketa Tanah Waris di Desa Adat Buduk
Authors: Widyantara I Gede Suka , Sukadana I Ketut , Sudibya Diah Gayatri 
Published: May 2020

Abstract-In the inheritance system, people in Bali have a system of inheritance that originates from the male kinship system which causes the relationship to be emphasized more according to the husband's lineage. Generally, any inheritance disputes do not have to end in court, because disputes about inheritance involve adat law in their resolution. Moreover, if the inheritance land dispute is still a family dispute, then the settlement should also be settled amicably through the active role of the Bendesa as the Leader in Pakraman Village. The formulation of the problem in this study is: How is the regulation of inheritance in Pakraman Buduk Village ?, What is the role of Bendesa in the settlement of inheritance land disputes in Pakraman Buduk Village? The problems discussed are examined from an empirical point of view. The results showed that the inheritance arrangement in Pakraman Buduk Village was in accordance with the contents of awig-awig Pakraman Buduk village contained in Palette 4 Pawos 75 to Pawos 78 which included inheritance, heirs, heir obligations, inheritance distribution, and loss of rights to be heir. The role of adat Bendesa in the settlement of inheritance land disputes in Desa Pakraman Buduk as a mediator.
Keywords: Inheritance, Bendesa, Dispute Resolution

Abstrak-Dalam sistem kewarisan, masyarakat di Bali memiliki sistem kewarisan yang bersumber dari sistem kekerabatan laki-laki yang menyebabkan pertalian hubungan lebih dititikberatkan menurut garis keturunan suami. Umumnya pada setiap sengketa tanah waris tidak harus berakhir di pengadilan, karena sengketa tentang waris melibatkan hukum adat dalam penyelesaiannya. Apalagi kalau sengketa tanah waris tersebut masih merupakan sengketa yang bersifat kekeluargaan, maka penyelesaiannya pun seharusnya diselesaikan secara kekeluargaan melalui peranan aktif dari pihak Bendesa selaku Pemimpin di Desa Pakraman. Rumusan masalah dalam penelitian ini adalah Bagaimana pengaturan warisan di Desa Pakraman Buduk ?, Bagaimana peranan Bendesa dalam penyelesaian sengketa tanah waris di Desa Pakraman Buduk ?. Permasalahan yang dibahas dikaji berdasarkan sudut pandang empiris. Hasil penelitian menunjukkan, bahwa Pengaturan warisan di Desa Pakraman Buduk sesuai dengan isi awig-awig Desa Pakraman Buduk termuat dalam Palet 4 Pawos 75 sampai dengan Pawos 78 yang mencakup tentang harta warisan, ahli waris, kewajiban ahli waris, pembagian warisan, dan kehilangan hak untuk menjadi ahli waris. Peranan Bendesa adat dalam penyelesaian sengketa tanah waris di Desa Pakraman Buduk sebagai mediator.
Kata Kunci: Warisan, Bendesa, Penyelesaian sengketa
Ekstradisi Sebagai Upaya Pencegahan Dan Pemberantasan Kejahatan Internasiona
Authors: Dewi Dwi Melia Nirmalananda , Sepud I Made , Sutama I Nyoman 
Published: May 2020

Abstract-The presence of a person to a country to escape resulted in the creation of many criminal crimes on an international scale, this requires special treatment, such as the existence of an international agreement, one of which is Extradition. Then it must be reviewed in advance regarding regulation and then move on to understanding the practice of extradition in preventing and combating international crime. The problems in this study are first, how is the regulation of extradition in preventing and combating international crime, second, how is the practice of extradition between countries in preventing and combating international crime. The research method used is a type of Normative research by using a statutory approach, conceptual approach and case approach which are analyzed using systematic techniques by being presented descriptively-analytically assisted with primary, secondary and tertiary legal sources which are collected and then interpreted. Focused on understanding and fulfilling the principles and procedures for compliance with international laws and conventions governing extradition and also focusing on cooperation between interested countries, in collaboration with ICPO-INTERPOL and NCB-INTERPOL who are competent in carrying out extradition.
Keywords: Between Countries, Extradition, International Crime.

Abstrak-Kehadiran seseorang ke suatu negara untuk melarikan diri mengakibatkan terciptanya banyak kejahatan-kejahatan pidana dengan skala internasional, ini membutuhkan penanganan khusus, seperti adanya perjanjian internasional salah satunya Ekstradisi. Maka wajiblah dikaji terlebih dahulu mengenai pengaturan lalu beranjak ke pemahaman praktek ekstradisi dalam mencegah dan memberantas kejahatan internasional. Adapun permasalah yang didapat dalam penelitian ini pertama, bagaimanakah pengaturan ekstradisi dalam mencegah dan memberantas kejahatan internasional, kedua, bagaimanakah praktek ekstradisi antar negara dalam mencegah dan memberantas kejahatan internasional. Metode penelitian yang digunakan merupakan tipe penelitian Normatif dengan melakukan pendekatan perundang-undangan, pendekatan konseptual dan pendekatan kasus yang dianalisis menggunakan teknik bersifat sistematis dengan disajikan secara deskriptif-analitis dibantu dengan sumber bahan hukum primer, sekunder dan tersier yang dikumpulkan lalu ditafsirkan. Difokuskan kepada pemahaman dan pemenuhan prinsip-prinsip serta tatacara pelaksanaan sesuai Undang-Undang dan konvensi Internasioal yang mengatur tentang Ekstradisi dan difokuskan pula kepada kerjasama antar negara yang berkepentingan, bekerjasama dengan ICPO-INTERPOL dan NCB-INTERPOL yang berkompeten dalam melaksanakan ekstradisi.
Kata Kunci: Antar Negara, Ekstradisi, Kejahatan Internasional.
FATORES DE RISCO E IDEAÇÃO SUICIDA EM PESSOAS COM TENTATIVA DE SUICÍDIO, FORTALEZA, CEARÁ, BRASIL
Authors: Oliveira Maria Ivoneide Veríssimo , Bezerra Filho José Gomes , Feitosa Regina Fátima Gonçalves , Sousa José Edir Paixão 
Published: May 2020

Considerado um problema de saúde pública pela crescente prevalência, o suicídio é uma das maiores causas de mortalidade no mundo, especialmente entre jovens. Anualmente, um milhão de pessoas cometem suicídio. No Brasil, a análise do perfil epidemiológico do suicídio tem demonstrado crescimento nas últimas décadas. Entre os estados brasileiros com as maiores taxas estão Rio Grande do Sul, Santa Catarina, Paraná, São Paulo e Goiás. Fortaleza é a sétima capital em suicídios. Este artigo visa descrever os fatores de risco associados à ideação suicida entre pessoas com história de tentativas de suicídio atendidas em unidades públicas de saúde de Fortaleza, Ceará, Brasil. Trabalhou-se com amostra por conveniência com 360 vítimas, nos centros de atenção psicossocial geral, álcool/drogas e infantil; adolescente, Instituto Doutor José Frota e Projeto Apoio à Vida da Universidade Federal do Ceará. A abordagem foi quantitativa com utilização de um questionário com perguntas estruturadas e escala de ideação suicida de Beck. Na análise estatística, usou-se como desfecho presença de ideação suicida, associado às variáveis independentes. Na análise multivariada mantiveram significância estatística: sentir-se rejeitado, RC = 1,99 (IC95%:1,21-2,57), p = 0,006; não seguir recomendações religiosas, RC = 1,82 (IC95%:1,10-3,0), p = 0,019; fazer tratamento para o problema de saúde, RC = 2,43 (IC95%:1,41-4,19), p = 0,001; e presença de depressão, RC = 1,096 (IC95%:1,07-1,12), p = 0,001. Necessariamente, novos estudos devem melhor explorar os resultados ora relatados e assim contribuir com ações e planejamento para a saúde mental de Fortaleza.
Palavras-chave: Fatores de risco. Ideação suicida. Tentativa de suicídio. Depressão. Saúde mental.
AS PRÁTICAS INTEGRATIVAS E COMPLEMENTARES EM SAÚDE E SUA RELAÇÃO COM AS EPISTEMOLOGIAS DO SUL
Authors: Silva Cleyton Cézar Souto , Medeiros Soraya Maria de 
Published: May 2020

Este trabalho é um ensaio crítico ancorado nas epistemologias do Sul e nas possibilidades que as práticas integrativas e complementares trazem quando ocorrem como política pública a fim de discutir a importância da (co)existência de saberes, conhecimento e práticas na saúde. Partimos da compreensão de que tais práticas são potentes por possibilitarem tanto o encontro real como simbólico dos saberes e das diferenças. As epistemologias do Sul tornam-se uma alternativa reflexiva para o cuidado em saúde pois são uma forma de constatar as dominações e limitações do paradigma dominante da ciência moderna e de suas relações desiguais de saber e poder. Desta forma, a prática e o cuidado em enfermagem podem se reinventar visando à superação dos paradigmas, efetivando uma postura mais abrangente em relação a saúde, doença e terapêutica que ultrapasse o modelo biomédico centrado no aspecto tecnomecanicista da ciência.
Palavras-chave: Terapias complementares. Saúde pública. Epistemologias do sul.
Ichthyofauna of Düzce Province (Turkey): Population and Habitat Evaluation
Authors: Güçlü Salim Serkan 
Published: May 2020

This study aimed to analyze the distribution, endemism-conservation status, habitat features of inland water fish species and some threats in Düzce inland water systems. Fish samples were collected using electrofishing equipment, gill nets, fyke nets, and cast nets between April-October 2016. We have identified 17 fish taxa belonging to 9 families (Salmonidae (1 taxa), Acheilognothidae (1 taxa), Cyprinidae (2 taxa), Gobionidae (1 taxa), Leuciscidae (7 taxa), Tincidae (1 taxa), Cobitidae (1 taxa), Percidae (1 taxa), Gobiidae (2 taxa)). As a result of field observations conducted in Düzce province inland water, we determined 4 endemic (Gobio baliki, Squalius pursakensis, Alburnoides coskuncelebii and Cobitis splendens) and 2 invasive species (Carassius gibelio, Oncorhynchus mykiss). Endemic species were observed in narrow areas and small populations. Fish fauna and habitats were observed to be under the influence of drying, water and sand extraction, dam and pond building, pollution, mining and invasive species pressure.
Características dos peritos contadores judiciais do estado de Pernambuco
Authors: Souza Vitória Regina Alves de , Santos Josaias Santana dos , Junior Florisvaldo Cunha Cavalcante 
Published: May 2020

A perícia contábil é um ramo da contabilidade que visa elaborar uma prova pericial ou laudo pericial. Trata-se de uma forma de garantir a veracidade das informações apresentadas pelas partes envolvidas em um processo judicial. Assim, a problemática deste artigo é investigar quais as particularidades da profissão de peritos contadores e o objetivo geral é caracterizar o perfil dos peritos contadores nas esferas judiciais do estado de Pernambuco. Realizou-se a coleta de dados por meio de questionário misto aplicado entre os peritos constantes no Cadastro Nacional de Peritos Contadores (CNPC) até 31 de dezembro de 2017. Os questionários foram enviados por e-mail para todos os cadastrados e foram obtidas 25 respostas, o que representa 18,65% do universo. A análise dos dados classifica-se como quantitativa e o método utilizado foi o Survey. Não obstante a área civil proporcionar uma remuneração maior, a atividade que apresentou maior demanda foi a área trabalhista. A obtenção de documentos necessários para a realização de perícia é a principal dificuldade citada pelos peritos. Constatou-se que as principais dificuldades dos peritos para se inserir no mercado de trabalho são: a obtenção de documentos necessários para a realização do processo, baixa remuneração, tempo para realização da perícia, nomeação por partes de juízes e apoio das partes envolvidas. De modo geral, os referidos profissionais estão satisfeitos com a profissão e participam de cursos de educação continuada duas vezes a cada seis meses.