bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postoperative diabetes insipidus: how to define and grade this complication?
Authors: de Vries Friso , Lobatto Daniel J. , Verstegen Marco J. T. , van Furth Wouter R. , Pereira Alberto M. , Biermasz Nienke R. 
Published: September 2020

Abstract
Purpose
Although transient diabetes insipidus (DI) is the most common complication of pituitary surgery, there is no consensus on its definition. Polyuria is the most overt symptoms of DI, but can also reflect several physiological adaptive mechanisms in the postoperative phase. These may be difficult to distinguish from and might coincide with DI. The difficulty to distinguish DI from other causes of postoperative polyuria might explain the high variation in incidence rates. This limits interpretation of outcomes, in particular complication rates between centers, and may lead to unnecessary treatment. Aim of this review is to determine a pathophysiologically sound and practical definition of DI for uniform outcome evaluations and treatment recommendations.

Methods
This study incorporates actual data and the experience of our center and combines this with a review of literature on pathophysiological mechanisms and definitions used in clinical studies reporting of postoperative DI.

Results
The occurrence of excessive thirst and/or hyperosmolality or hypernatremia are the best indicators to discriminate between pathophysiological symptoms and signs of DI and other causes. Urine osmolality distinguishes DI from osmotic diuresis.

Conclusions
To improve reliability and comparability we propose the following definition for postoperative DI: polyuria (urine production > 300 ml/hour for 3 h) accompanied by a urine specific gravity (USG) < 1.005, and at least one of the following symptoms: excessive thirst, serum osmolality > 300 mosmol/kg, or serum sodium > 145 mmol/L. To prevent unnecessary treatment with desmopressin, we present an algorithm for the diagnosis and treatment of postoperative DI.
From Indigenous Customary Law to Diasporic Cultural Heritage: Reappropriations of Adat Throughout the History of Moluccan Postcolonial Migration
Authors: van Engelenhoven Gerlov 
Published: September 2020

AbstractAdat is originally an Arabic term meaning “custom” or “habit”, and was introduced by Islamic merchants in Maluku and throughout the Indonesian archipelago from the 1200s onward. The term was used as a way to refer to indigenous customs that could not be incorporated into Islamic law. Therefore, rather than referring to a particular system of customs or laws, adat denoted Islamic law’s indeterminate opposite: i.e. the wide variety of indigenous practices which, other than this generalizing label of “custom”, remained undefined. Throughout the chapter, I will trace the development of this term from its original usage to its current-day reinterpretation as a form of diasporic cultural heritage by the Moluccan postcolonial migrant community in the Netherlands. As will become clear, the contemporary Moluccan application can be understood as a strategic reappropriation of the term for the construction of their collective identity, which leaves intact the term’s original capacity of having no fixed definition. By placing the Moluccan application of adat within the historical context of their separatist ideology vis-à-vis Indonesia, and their migration to the Netherlands in the early 1950s, I will argue that their reappropriation of adat as a deliberately indefinable form of Moluccan cultural heritage can be understood as a way for them to protect their collective identity as a separatist people from becoming a matter of wider contestation.
Structural and functional comparison of Saccharomonospora azurea strains in terms of primycin producing ability
Authors: Kovács Márk , Seffer Dénes , Pénzes-Hűvös Ágota , Juhász Ákos , Kerepesi Ildikó , Csepregi Kitti , Kovács-Valasek Andrea , Fekete Csaba 
Published: September 2020

AbstractEmerging and re-emerging microbial pathogens, together with their rapid evolution and adaptation against antibiotics, highlight the importance not only of screening for new antimicrobial agents, but also for deepening knowledge about existing antibiotics. Primycin is a large 36-membered non-polyene macrolide lactone exclusively produced by Saccharomonospora azurea. This study provides information about strain dependent primycin production ability in conjunction with the structural, functional and comparative genomic examinations. Comparison of high- and low-primycin producer strains, transcriptomic analysis identified a total of 686 differentially expressed genes (DEGs), classified into diverse Cluster of Orthologous Groups. Among them, genes related to fatty acid synthesis, self-resistance, regulation of secondary metabolism and agmatinase encoding gene responsible for catalyze conversion between guanidino/amino forms of primycin were discussed. Based on in silico data mining methods, we were able to identify DEGs whose altered expression provide a good starting point for the optimization of fermentation processes, in order to perform targeted strain improvement and rational drug design.
Polygonisation of railway wheels: a critical review
Authors: Tao Gongquan , Wen Zefeng , Jin Xuesong , Yang Xiaoxuan 
Published: September 2020

AbstractPolygonisation is a common nonuniform wear phenomenon occurring in railway vehicle wheels and has a severe impact on the vehicle–track system, ride comfort, and lineside residents. This paper first summarizes periodic defects of the wheels, including wheel polygonisation and wheel corrugation, occurring in railways worldwide. Thereafter, the effects of wheel polygonisation on the wheel–rail interaction, noise and vibration, and fatigue failure of the vehicle and track components are reviewed. Based on the different causes, the formation mechanisms of periodic wheel defects are classified into three categories: (1) initial defects of wheels, (2) natural vibration of the vehicle–track system, and (3) thermoelastic instability. In addition, the simulation methods of wheel polygonisation evolution and countermeasures to mitigate wheel polygonisation are presented. Emphasis is given to the characteristics, effects, causes, and solutions of wheel polygonisation in metro vehicles, locomotives, and high-speed trains in China. Finally, the guidance is provided on further understanding the formation mechanisms, monitoring technology, and maintenance criterion of wheel polygonisation.
Integrating Interventions That Can Support a Career-Oriented Recovery for Young Adults: Building on the Supported Education Knowledge Base
Authors: Hillborg Helene , Lövgren Veronica , Bejerholm Ulrika , Rosenberg David 
Published: September 2020

AbstractYoung adults experiencing mental health problems are less educated than their peers, putting them in a more vulnerable position for employment and career possibilities. While Supported employment models have been widely implemented, educational supports may be necessary in order to contribute to longer term and sustainable employment. The aim of this study was to describe the state of current research regarding Supported education services for individuals with mental health problems, with a particular focus on studies that address both educational and vocational goals. A scoping review of articles published between 2000 and July 2020 was conducted. Eight databases were searched, titles/abstracts and full-text articles were reviewed for inclusion. The results, which built on 56 included articles, were analysed both descriptively and thematically. The results suggest that the focus in the literature has primarily been on adapting and implementing models for the needs of different populations and contexts. Many of these build on integrated models focusing on both vocational and educational needs. Despite addressing varied populations and working in varied contexts, it is possible to identify a number of essential components when delivering educational support. The review suggests a need to look at work and studies as equally important from a career development perspective. The knowledge base developed through studying supported education services and the educational components of newly emerging services, can contribute to the further development of integrated models for young adults.
Assessment of coal gasification in a pressurized fixed bed gasifier using an ASPEN plus and Euler–Euler model
Authors: Ismail Tamer M. , Shi Mingliang , Xu Jianliang , Chen Xueli , Wang Fuchen , El-Salam M. Abd 
Published: September 2020

AbstractWith the help of Aspen Plus, a two-dimensional unsteady CFD model is developed to simulate the coal gasification process in a fixed bed gasifier. A developed and validated two dimensional CFD model for coal gasification has been used to predict and assess the viability of the syngas generation from coal gasification employing the updraft fixed bed gasifier. The process rate model and the sub-model of gas generation are determined. The particle size variation and char burning during gasification are also taken into account. In order to verify the model and increase the understanding of gasification characteristics, a set of experiments and numerical comparisons have been carried out. The simulated results in the bed are used to predict the composition of syngas and the conversion of carbon. The model proposed in this paper is a promising tool for simulating the coal gasification process in a fixed bed gasifier.
Critical Care Medical Centers May Play an Important Role in Reducing the Risk of COVID-19 Death in Japan
Authors: Ishikawa Yohei , Hifumi Toru , Urashima Mitsuyoshi 
Published: September 2020

AbstractMarked differences in COVID-19 mortalities have been observed among 47 prefectures in Japan. Here, we explored associations between COVID-19 mortalities and medical and public health capacities in individual prefectures. The following data by prefecture were abstracted from open resources provided by the Ministry of Health, Labour and Welfare in Japan as of May 24, 2020: total number of COVID-19 deaths; polymerase chain reaction (PCR)-positive ratio (i.e., number of patients with PCR-positive results/number of patients aiming diagnosis of COVID-19 or individuals in close contacted with COVID-19 patients); number of call centers, outpatient centers, and hospital beds specifically for patients diagnosed with COVID-19; and others. The primary outcome was COVID-19 mortality per million population. Multiple and simple linear regression models were applied. Two variables were significantly associated with COVID-19 mortality: PCR-positive ratio (P < 0.001) and number of critical care medical centers per million population (P = 0.001). PCR-positive ratio was positively associated with COVID-19 mortality (aR-sqr = 0.522). Low PCR-positive ratio, especially ≤ 4%, was associated with low COVID-19 mortality. Critical care medical centers may also play an important role in reducing the risk of COVID-19 death.
Markov chains with exponential return times are finitary
Authors: ANGEL OMER , SPINKA YINON 
Published: September 2020

AbstractConsider an ergodic Markov chain on a countable state space for which the return times have exponential tails. We show that the stationary version of any such chain is a finitary factor of an independent and identically distributed (i.i.d.) process. A key step is to show that any stationary renewal process whose jump distribution has exponential tails and is not supported on a proper subgroup of
${\mathbb {Z}}$
is a finitary factor of an i.i.d. process.
The Data on Gender Inequality in Philosophy: The Spanish Case
Authors: Torres González Obdulia 
Published: September 2020

AbstractThis article examines gender imbalance in philosophy using statistical analysis of philosophy professionals and students in Spain. It is the only study on an international scope that provides complete, real data of an entire national system. This analysis shows that among teaching and research personnel, women make up 25% of the total, among full professors they represent 12%, and the glass-ceiling index in the field is the same as that in engineering. For the study, I resorted to a normalization of indicators to allow for international comparisons, which I have done using the reports and analyses available in other countries. In the second part of the article, I use the Spanish data to test some recent hypotheses on gender imbalance in philosophy. The data does not confirm the theory of Neven Sesardic and Rafael de Clercq, which attributes the imbalance to differences in cognitive abilities (Sesardic and Clercq 2014). However, the data does partially confirm the study by Molly Paxton, Carrie Figdor, and Valerie Tiberius regarding the dissuasive effect of introductory courses in philosophy (Paxton, Figdor, and Tiberius 2012), as well as that by Sarah Leslie and her colleagues on the field-specific abilities belief hypothesis (Leslie et al. 2015).
Fit for the future? Status of health-related quality of life research in South Africa
Authors: Marsh Sophia E. , Truter Ilse 
Published: September 2020

ObjectiveTo provide insights into the attributes of health-related quality of life (HRQoL) research within the context of economic evaluations for a potential national health technology assessment process in South Africa, and make evidence generation recommendations.MethodsA systematic review was conducted in January 2019 using Medline, the Web of Science (WoS) Core Collection and the South African SciELO collection via the WoS Platform, and in the Cochrane Library. No time restrictions were applied. Duplicate records were removed before first- and second-pass screening by two reviewers working independently.ResultsThe review identified 123 publications representing 104 studies since the first-published article appeared in 1996. Only eight studies were randomized controlled trials, most were cross-sectional (n = 54). The EQ-5D, SF-36, and WHOQOL-BREF were the most used HRQoL instruments (n = 35, n = 23, and n = 10, respectively). Instruments were frequently administered in multiple languages, reflecting the cultural groups in which the study was conducted, with the English version of instruments used most often. Studies were predominantly conducted within the public health sector (n = 67), in the Western Cape province (n = 46), in adults (n = 92) and people with HIV (n = 24).ConclusionSouth African specific HRQoL studies have been conducted in a range of settings and populations using mostly generic HRQoL instruments in multiple languages. These studies may provide generalizable, real-world data due to their observational nature. However, more comparative and longitudinal studies should be conducted as this is preferred for economic evaluations and patient, disease, and treatment characteristics should be reported in full.
Massive application of the SARS-CoV-2 diagnostic test: simulation of its effect on the evolution of the epidemic in Spain
Authors: López-Abente Jacobo , Valor-Suarez Clara , López-Abente Gonzalo 
Published: September 2020

Abstract
In Spain, the epidemic curve caused by COVID-19 has reached its peak in the last days of March. The implementation of the blockade derived from the declaration of the state of alarm on 14th March has raised a discussion on how and when to deal with the unblocking. In this paper, we intend to add information that may help by using epidemic simulation techniques with stochastic individual contact models and several extensions.
Strain Signals Before and During Paroxysmal Activity at Stromboli Volcano, Italy
Authors: Di Lieto Bellina , Romano Pierdomenico , Scarpa Roberto , Linde Alan Trevor 
Published: September 2020

AbstractIn the last decades, Mt. Stromboli produced four vulcanian eruptions, in 2003 and 2007 and July and August 2019, recorded by INGV monitoring network. Specifically, last three events are studied through records from borehole strainmeters, which allow to infer details on source dynamics. These events are preceded by a slow strain buildup, starting several minutes before the paroxysms, which can be used in future for early warning. Eruptions consist of two or more strain pulses, with oscillations ranging from several seconds, as in 2007, to some minutes, as in 2019, and lasting from several minutes to 1 hr after the explosions.
A New Evaluation of the Role of Urbanization to Warming at Various Spatial Scales: Evidence From the Guangdong‐Hong Kong‐Macau Region, China
Authors: Chao Liya , Huang Boyin , Yuanjian Yang , Jones Phil , Cheng Jiayi , Yang Yang , Li Qingxiang 
Published: September 2020

AbstractThe urbanization impacts on surface air temperature (SAT) change in the Guangdong‐Hong Kong‐Macau region (GHMR) from 1979 to 2018 are examined using homogeneous surface observations, reanalysis, and remote sensing. Results show that the warming due to urbanization tends to be smaller or insignificant as the spatial scale increases. The urbanization contribution to the local warming can reach as high as 50% in the center of each metropolis, remains high (~25%) in the Greater Bay Area (GBA), and decreases to about 10% in the whole GHMR. The warming in GHMR is nearly uniform throughout the day, and therefore, the observed trend of the diurnal temperature range (DTR) is not statistically significant. However, the urbanization contribution exhibits distinct seasonal variations, large in summer and autumn while smaller in winter and spring.
The impact of a supranetwork multidisciplinary team (SMDT) on decision-making in testicular cancers: a 10-year overview of the Anglian Germ Cell Cancer Collaborative Group (AGCCCG)
Authors: Shamash Jonathan , Ansell Wendy , Alifrangis Constantine , Thomas Benjamin , Wilson Peter , Stoneham Sara , Mazhar Danish , Warren Anne , Barrett Tristan , Alexander Susanna , Rudman Sarah , Lockley Michelle , Berney Daniel , Sahdev Anju 
Published: September 2020

Abstract
Background
The germ cell supranetwork multidisciplinary team (SMDT) for the Anglian Network covers a population of 7.5 million.

Methods
We reviewed 10 years of SMDT discussion and categorised them into five domains ((1) overall outcome, (2) chemotherapy regimens—untreated disease and salvage therapy, (3) radiology, (4) pathology and (5) complex cases) to assess the impact of the SMDT.

Results
A total of 2892 new cases were reviewed. In the first 5 years, patients with good prognosis disease had poorer survival in low-volume vs high-volume centres (87.8 vs 95.3, p = 0.02), but the difference was no longer significant in the last 5 years (93.3 vs 95.1, p = 0.30). Radiology review of 3206 scans led to rejection of the diagnosis of progression in 26 cases and a further 10 cases were down-staged. There were 790 pathology reviews by two specialised uropathologists, which lead to changes in 75 cases. 18F-fluorodeoxyglucose (18FDG) PET-CT was undertaken during this time period but did not help to predict who would have viable cancer. A total of 26 patients with significant mental health issues who were unable to give informed consent were discussed.

Conclusion
SMDT working has led to an improvement in outcomes and refining of treatment in patients with germ cell tumours.
Quality improvement for cancer multidisciplinary teams: lessons learned from the Anglian Germ Cell Cancer Collaborative Group
Authors: Soukup Tayana , Sevdalis Nick , Green James S. A. , Lamb Benjamin W. 
Published: September 2020

SummaryShamash and colleagues describe how their supra-regional germ cell tumour multidisciplinary team achieved standardisation of treatment and improved survival. We discuss some of the insights the study provides into prioritising complex patients, streamlining processes, the use of telemedicine, and the centrality of good data collection to continuous quality improvement.
Atomic structure of human TOM core complex
Authors: Wang Wenhe , Chen Xudong , Zhang Laixing , Yi Jingbo , Ma Qingxi , Yin Jian , Zhuo Wei , Gu Jinke , Yang Maojun 
Published: September 2020

AbstractThe translocase of the outer mitochondrial membrane (TOM) complex is the main entry gate for mitochondrial precursor proteins synthesized on cytosolic ribosomes. Here we report the single-particle cryo-electron microscopy (cryo-EM) structure of the dimeric human TOM core complex (TOM-CC). Two Tom40 β-barrel proteins, connected by two Tom22 receptor subunits and one phospholipid, form the protein-conducting channels. The small Tom proteins Tom5, Tom6, and Tom7 surround the channel and have notable configurations. The distinct electrostatic features of the complex, including the pronounced negative interior and the positive regions at the periphery and center of the dimer on the intermembrane space (IMS) side, provide insight into the preprotein translocation mechanism. Further, two dimeric TOM complexes may associate to form tetramer in the shape of a parallelogram, offering a potential explanation into the unusual structural features of Tom subunits and a new perspective of viewing the import of mitochondrial proteins.
Early-onset renal cell carcinoma in PTEN harmatoma tumour syndrome
Authors: Kim Raymond H. , Wang Xiangling , Evans Andrew J. , Campbell Steven C. , Nguyen Jane K. , Farncombe Kirsten M. , Eng Charis 
Published: September 2020

AbstractIndividuals with PTEN hamartoma tumour syndrome (PHTS), including Cowden syndrome (CS), are susceptible to multiple benign hamartomas and an increased risk of cancer, particularly breast, endometrial, and thyroid. As a result, individuals undergo enhanced surveillance for early detection of these cancers. However, less commonly occurring cancers, such as colorectal and kidney, have insufficient guidelines for early detection. Currently, screening for kidney cancer via renal ultrasound begins at 40 years of age, because there were only rare cases of elevated risk in prospective series under 40. There have, however, been accumulating reports of kidney cancer in individuals with CS in their 30s, illustrating a need to lower the age of surveillance. We present additional evidence of renal cell carcinoma in two individuals with CS in their early twenties, and propose a reassessment of the abdominal surveillance in patients with PHTS. We propose biannual screening for kidney cancer beginning at 20 years of age.
Origin and structure of liquid crystalline Blue Phase III
Authors: Paul Tanay , Saha Jayashree 
Published: September 2020

AbstractWe report here an off-lattice NVT molecular dynamics simulation study of a system of polar chiral ellipsoidal molecules, which spontaneously exhibits Blue Phase III (BPIII), considering coarse-grained attractive-repulsive pair interaction appropriate for anisotropic liquid crystal mesogens. We have observed that suitable selection of chiral and dipolar strengths not only gives rise to thermodynamically stable BPIII but novel Smectic and Bilayered BPIII as well. Further, we have demonstrated that the occurrence of BPIII and its layered counterparts depend crucially on molecular elongation.