bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between nature exposure, screen use, and parent-child relations: a scoping review
Authors: Torjinski Marina , Cliff Dylan , Horwood Sharon 
Published: December 2024

Abstract
Background
Recent research suggests that children spend increasing amounts of time engaging in screen-based activities and less time outdoors in natural environments. There is a growing body of theory-driven literature evidencing that child screen use and exposure to nature are associated with wellbeing outcomes in contrasting ways. However, few studies have explored their combinative effects, and the relational family context has been largely overlooked.

Objective
This scoping review explored associations between early-late childhood nature exposure, screen use, and parent-child relations to identify research gaps and inform future research direction.

Methods
This review was guided by Arksey and O’Malley’s five-stage methodological framework and other relevant guidelines for scoping reviews. A search of five electronic databases (PsycINFO, MEDLINE complete, ERIC, EMBASE, and Cochrane library) was conducted along with additional hand-searches from inception to 9/08/2024. Peer-reviewed articles published in English between 2012 and 2024 were included.

Results
A total of 390 articles were screened by title and abstract and full text review of 96 articles was conducted. Following additional searches (hand-search and reference lists), a total of 23 eligible articles were identified. Evidence is presented in tabular and textual form and described using qualitative thematic analysis. The synthesis revealed that the relevant body of research is novel, heterogenous, and fragmented. There are various pathways through which children’s screen use and engagement with nature interact within the family context; however, research exploring their synchronous and bidirectional effects on relational family processes is limited.

Conclusion
Findings emphasize the importance of investigating children’s screen use and engagement with nature from a relational paradigm. Future studies should explore the mechanisms underpinning the reciprocal influences of nature and screen use on dyadic family processes and relational outcomes across early-late childhood.

OSF registration
https://doi.org/10.17605/OSF.IO/TFZDV.
NOX proteins and ROS generation: role in invadopodia formation and cancer cell invasion
Authors: Quilaqueo-Millaqueo Nelson , Brown-Brown David A. , Vidal-Vidal Jetzabel A. , Niechi Ignacio 
Published: December 2024

AbstractNADPH oxidases (NOX) are membrane-bound proteins involved in the localized generation of reactive oxygen species (ROS) at the cellular surface. In cancer, these highly reactive molecules primarily originate in mitochondria and via NOX, playing a crucial role in regulating fundamental cellular processes such as cell survival, angiogenesis, migration, invasion, and metastasis. The NOX protein family comprises seven members (NOX1-5 and DUOX1-2), each sharing a catalytic domain and an intracellular dehydrogenase site. NOX-derived ROS promote invadopodia formation, aberrant tyrosine kinase activation, and upregulation of matrix metalloproteinases (MMPs). Specifically, NOX5 modulates adhesion, motility, and proteolytic activation, while NOX1 likely contributes to invadopodia formation and adhesive capacity. NOX2 and NOX4 are implicated in regulating the invasive phenotype, expression of MMPs and EMT markers. DUOX1-2 participate in epithelial-mesenchymal transition (EMT), crucial for invasive phenotype development. Soluble molecules such as TGF-β and EGF modulate NOX protein activation, enhancing cell invasion through localized ROS production. This review focuses on elucidating the specific role of NOX proteins in regulating signaling pathways promoting cancer cell spread, particularly EMT, invadopodia formation and invasive capacity.
A decade of genetic makeup in the aerial seed bank of a fire-evader tree
Authors: Callejas-Díaz Marta , Climent José M. , Grivet Delphine 
Published: December 2024

Abstract
Background
Aerial seed banks occur in plants that postpone the release of viable seeds, thereby providing a mechanism for population maintenance in unpredictable environments. Seeds retained on the mother trees offer a reservoir of genetic diversity across years, but the pattern and evolutionary consequences of such accumulated diversity are poorly understood. We characterize the genetic layout of an aerial seed bank composed of serotinous cones formed in 2003 and in 2014 in a historically fire-prone area. Our hypothesis is that within this timeframe, recurrent fires could have modified the genetic makeup of the seed bank.

Results
Our results did not reveal any genetic difference along the 12-year period, but indicated a significant genetic variation (13%) of seed banks among trees within the same year. Moreover, progeny from the seed bank showed a 4% increase of observed heterozygosity, together with 14 new alleles, compared to mother trees. Finally, a strong homogenization effect of pollen flow on the genetic diversity was detected, with a very high effective number of fathers in 2003 and 2014.

Conclusions
Our results highlight the temporal stability of the genetic makeup of aerial seed banks in this fire-prone area. The maternal genetic differences and an increase of genetic diversity (linked to effective pollen flow) in new generations compared to their maternal progenitors are also noteworthy. Together, these characteristics represent key assets for serotinous forest adaptation and persistence in the face of increasing wildfire activity.
Serum levels of auto-antibodies (rheumatoid factor and anti-double stranded DNA) in Nigerian COVID-19 patients
Authors: Oladokun Haleemat Yejide , Rahamon Sheu Kadiri , Yaqub Surajudeen Adebayo , Onifade AbdulFattah Adekunle , Arinola Ganiyu Olatunbosun 
Published: December 2024

Abstract
Background
A thorough understanding of how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contributes to autoantibody development is essential to clarify the possibility of autoimmune disorders in COVID-19 patients. Consequently, this study measured serum levels of rheumatoid factor (RF) and anti-double stranded DNA antibody (dsDNA ab), two key markers of autoimmune disorders, in COVID-19 patients and in apparently healthy controls.

Methods
Serum levels of rheumatoid factor and anti-dsDNA antibody were determined using turbidimetric immunoassay and enzyme linked immunosorbent assay (ELISA) respectively in both COVID-19 patients (n = 40) and healthy controls (n = 28).

Results
Serum levels of RF and anti-dsDNA antibody were similar in COVID-19 patients compared with controls. A significant positive correlation was observed between RF and anti-dsDNA antibody in healthy controls. The correlation between RF and anti-dsDNA antibody in COVID-19 patients was not significant.

Conclusion
SARS-CoV-2 infection did not significantly impact serum RF and anti-dsDNA antibody levels in the present infected individuals. Thus, autoimmune disorders are not indicated in these COVID-19 patients, and using therapeutic antagonists to target auto-antibodies may not be beneficial in managing COVID-19, as these patients are unlikely to develop an autoimmune disorder related to COVID-19.
Radiating South
Authors: Rath Thomas 
Published: December 2024

Abstract
From the 1960s to the 1990s, the US Department of Agriculture led a campaign across North America to eradicate a notorious livestock pest known as the screwworm. It did so by breeding flies in factories, sterilizing them with radiation, and scattering them from the air. Based on original multisite archival research, this article examines the overlooked role of Mexico in what was a flagship application of the “sterile male technique.” It argues that three main factors shaped this role: Mexico's long-term projects of agricultural and atomic modernization; diplomatic leverage provided by a shared border; and an earlier tradition of bilateral cooperation and conflict over animal disease that stretched back to the 1940s. The analysis deepens our understanding of how Mexico shaped science and agriculture at home and abroad. It also helps explain why this particular project of atomic agriculture succeeded on the scale it did.
Cardiac magnetic resonance imaging in repaired tetralogy of Fallot: A longitudinal midterm follow-up study
Authors: Houshmand Golnaz , Rahmati Rahem , Meftah Elahe , Zarimeidani Fatemeh , Khorgami Mohammadrafi , Ghorashi Seyyed Mojtaba , Fazeli Amir , Omidi Negar , Saedi Sedigheh , Motevalli Marzieh , Maleki Majid , Pouraliakbar Hamidreza 
Published: December 2024

Background
Biventricular dysfunction is frequent in patients with repaired tetralogy of Fallot, necessitating routine imaging to monitor for worsening conditions and determine whether procedures like pulmonary valve replacement (PVR) are needed. This study aimed to highlight the parameters of cardiac magnetic resonance imaging (CMR) and their association with adverse outcomes in the midterm follow-up of these patients.

Methods
This longitudinal study recruited all patients with a history of tetralogy of Fallot total correction (TFTC) who had two CMR images at a minimum three-month interval at Rajaie Center from 2007 through 2017.

Results
Fifty-six patients at a mean age of 15.23 ± 11.66 years at TFTC and a 1:1 gender distribution were assessed. Regarding adverse events, PVR was done on 18 patients (32%). Right and left ventricular dysfunction occurred in 43 (76.8%) and 18 (32.1%) patients, respectively. Death did not occur in the present study. RVOT fibrosis was present in 47 (92.2%). The stroke volume of both ventricles increased during the follow-up (P <0.05), although end-diastolic volume indices, end-systolic volume indices, ejection fractions, strain parameters, and ventriculoarterial coupling did not change significantly. Patients requiring PVR had a significantly higher end-systolic volume index in both ventricles (P <0.05) and a lower right-sided ejection fraction (P <0.01) and coupling ratio (P <0.05). The ejection fraction in the left ventricle correlated with global circumferential strain (P <0.01), while in the right ventricle, it correlated with global longitudinal strain (P <0.05) and the right-sided coupling ratio (P <0.01).

Conclusion
Myocardial strain and ventriculoarterial coupling parameters could underscore personalized-approached therapy and follow-up to improve outcomes.
Self-reported dyspareunia and outcome satisfaction after spontaneous second-degree tear compared to episiotomy: A register-based cohort study
Authors: Josefsson Mette L. , Sohlberg Sara , Ekéus Cecilia , Uustal Eva , Jonsson Maria 
Published: December 2024

Introduction
Symptoms after second-degree tears and in particular episiotomies are common. Our aim was to investigate the prevalence and degree of dyspareunia and level of satisfaction with the outcome of the perineal repair after a spontaneous second-degree tear compared to an episiotomy. Further, we aimed to identify risk factors for dyspareunia and dissatisfaction with the outcome.

Material and methods
This register-based cohort study included 5 328 primiparous women who sustained a spontaneous second-degree tear (n = 4 323) or an episiotomy (n = 1005) between 2014 and 2019 in Sweden. The primary outcomes were self-reported degree of dyspareunia and level of satisfaction with the outcome of the perineal repair at one year. Data were collected from national health and quality registers and online questionnaires at eight weeks and one year. Logistic regression was used and results are presented by Odds Ratios (OR) with 95% confidence intervals (CI) after adjustment for age, body mass index and mode of delivery.

Results
30.0% of women with a spontaneous tear and 29.1% of women with an episiotomy reported mild or moderate dyspareunia, while 2.4% of women with a spontaneous tear compared to 3.8% of women with an episiotomy reported strong or unbearable dyspareunia (aOR 1.5; CI 0.9–2.4). 73.4% of women with a spontaneous tear and 67.1% with episiotomy were satisfied or very satisfied with their outcome, while 6.7% with an episiotomy compared to 3.7% with a spontaneous tear were dissatisfied (aOR 1.8; CI 1.2–2.6). Postpartum infection, scar dehiscence, re-suturing and perineal pain at eight weeks were risk factors for dyspareunia and dissatisfaction at one year.

Conclusions
Approximately one-third of women with either a spontaneous tear or an episiotomy reported mild or moderate dyspareunia at one year, while strong or unbearable pain was uncommon in both groups. The majority of women were satisfied or very satisfied with the outcome although episiotomy more often predicted dissatisfaction.
Primerjava krajše ležalne dobe in stopnje ponovnih sprejemov v terciarni bolnišnici pri otročnicah, pozitivnih na covid-19, v antenatalnem obdobju
Authors: Višič Uroš 
Published: December 2024

Uvod: Pandemija virusa covid-19 je predstavljala veliko tveganje tudi na perinatalnem področju. Namen pričujoče raziskave je bil preučiti trajanje bivanja otročnic, pozitivnih na covid-19, po vaginalnem porodu v zgodnjem poporodnem obdobju v primerjavi s standardnim trajanjem in stopnjo njihovih ponovnih sprejemov v primerjavi s standardnimi sprejemi pri zdravi populaciji.Metode: Uporabljena je bila retrospektivna kohortna raziskava s pregledom trajanja ležalne dobe po vaginalnemporodu in po carskem rezu. Vključenih je bilo 322 otročnic. Podatke, pridobljene iz informacijskega sistema Hipokrat, smo analizirali z opisno statistiko in t-testom ob upoštevani statistični značilnosti p < 0,05.Rezultati: V povprečju je ležalna doba po vaginalnem porodu (Me = 2,45) in po carskem rezu (Me = 4,05) trajala dlje od zastavljenega trajanja. Maksimalna ležalna doba po vaginalnem porodu je bila približno tri dni (Maks = 3,06), po carskem rezu pa štiri dni (Maks = 4,38). Rezultati niso pokazali statistično značilnih razlik med ležalno dobo po vaginalnem porodu (p = 0,38) in carskem rezu (p = 0,21). Diskusija in zaključek: Ugotovljeno je bilo, da je kljub predvideni krajši ležalni dobi otročnic, pozitivnih na covid-19, njihova obravnava zanemarljivo daljša. Potrebne so nadaljne raziskave v zgodnjem postnatalnem obdobju.
Jogo, prática corporal e processo de formação do sujeito/critico
Authors: Rodrigues Rogério 
Published: December 2024

O jogo é um fenômeno social praticado amplamente pelos sujeitos, independentemente da idade ou da posição social que estes ocupem na sociedade. As características pertinentes da amostra não se aplicam, pois a referida análise é algo que trata diretamente da experiencia de vida. Os nossos resultados indicam que o gosto pela prática do jogo é algo independente de idade ou posição que o sujeito ocupe na sociedade. Temos como conclusão que a escolha do jogo pelo sujeito pode ser algo consciente em razão do nosso gosto, portanto, podemos optar por um determinado tipo de jogo. Contudo, nesta escolha estão presentes determinantes inconscientes, dos quais o sujeito nada quer saber. Estas escolhas realizadas pelo gosto dos sujeitos por determinados jogos é que lhe permitem investir em determinados afetos que possibilitariam ou não a elaboração de sua própria existência e a condição do seu eu – o processo de formação do sujeito/critico.
Editorial
Authors: Iriondo Otero Walter Ruben 
Published: December 2024

Temos imenso prazer em apresentar uma nova edição da Revista Prociências, periódico científico de natureza multidisciplinar, que tem por finalidade a divulgação de artigos sobre a temática Ciência, Tecnologia e Sociedade e a sua relação com conceitos de Inovação, Cidadania, Ética e a Responsabilidade Social.
Essa nova edição da Revista apresenta trabalhos submetidos por pesquisadores de instituições do Brasil e do exterior. Dentre os artigos que abordam temas da área da educação, encontramos a discussão relativa ao papel dos tutores em ambientes virtuais de ensino e aprendizagem, enfatizando as funções da concepção de espaços de aprendizagem e a mediação na comunicação; assim como a relação entre juventude, qualificação profissional e inserção no trabalho; e os principais condicionantes ergonômicos impostos aos professores da rede de ensino no que se refere à organização do trabalho.
A preocupação de pesquisadores com a questão ambiental e a sustentabilidade também está presente nessa edição da Revista, que apresenta um projeto para a concepção de uma estrutura vertical para o cultivo de plantas alimentícias em ambiente urbano; assim como um estudo que utiliza a metodologia de Dinâmica de Sistemas para modelar e comparar cenários de reciclagem de plásticos, avaliando seus impactos ambientais, financeiros e suas oportunidades dentro de uma economia circular.
Parabenizamos aos autores pela publicação dos artigos, e agradecemos à Comissão Científica pela inestimável contribuição nas avaliações dos trabalhos que apresentamos nesta edição.
Gostaríamos também de mencionar que a Revista Prociências recebe contribuições em fluxo contínuo, ação que contempla a submissão, recebimento e avaliação de artigos durante o ano todo; e também aceita propostas da comunidade científica internacional para publicação de Edições Especiais, no formato Dossiê ou Edição Temática. Aguardamos, portanto, o recebimento de trabalhos inéditos para as próximas edições da Revista.
Desejamos a todos uma proveitosa leitura!
Prof. Dr. Walter R. Iriondo Otero (Editor)
Primary hyperparathyroidism due to a giant parathyroid adenoma presenting with pathological fractures and multiple brown tumors
Authors: Meng Jassy , Aboznadah Wedyan M , Pusztaszeri Marc , Larouche Vincent 
Published: December 2024

SummaryPrimary hyperparathyroidism (PHPT) is a disorder in which excessive parathyroid hormone (PTH) is secreted from the parathyroid glands. The cause of PHPT is most commonly parathyroid lesions such as parathyroid adenoma. The clinical manifestations of PHPT include hypercalcemia, nephrolithiasis, bone disease and rarely pathological fractures and brown tumors, which arise within the foci of osteitis fibrosa. Brown tumors are benign intraosseous tumors that occur because of excessive osteoclast activity. Because of advances in medical care, early diagnosis and treatment have meant that diagnosing PHPT in the setting of multiple brown tumors is particularly rare. Here, we present a case of a young man with prolonged PHPT from a giant parathyroid adenoma with multiple brown tumors causing pathological fractures. Definitive treatment of PHPT is parathyroidectomy with particular attention to the risks for hungry bone syndrome (HBS) postoperatively.Learning pointsPathological fractures from brown tumors are a rare but significant concern in prolonged PHPT, and a multidisciplinary approach is required including orthopedic surgery, otolaryngology and endocrinology.It is important to assess PTH and calcium in the context of hypercalcemia with bone lesions to avoid potential diagnostic delays.Postoperative parathyroidectomy patients with large parathyroid adenomas, elevated alkaline phosphatase, elevated PTH and the presence of brown tumors are at particularly high risk for HBS.Very high levels of PTH, calcium, alkaline phosphatase and multiple brown tumors should raise concern for a potential case of parathyroid carcinoma.Indications for genetic testing for inheritable parathyroid disease include patients younger than 30 years old, those with multigland disease, those with a family history of hypercalcemia or syndromic disease and those with atypical parathyroid adenoma and parathyroid carcinoma.
Teaching and learning medical English for international medical graduates: A scoping review
Authors: Ng Chiew Hong , Cheung Yin Ling 
Published: December 2024

This paper reviews research on teaching and learning English for international communication in diverse contexts for international medical graduates (IMGs) using medical English as a lingua franca. Through keyword searches in Scopus and EBSCOhost research databases of English-medium peer-reviewed refereed journals from 2008 to 2022, 33 articles were selected to answer three research questions for the present study. The findings highlight the complexity, diversity and challenges of teaching and learning medical English for international communication for IMGs in terms of learners' needs and difficulties in learning medical English (e.g., low proficiency levels and issue of communicative competence), specific courses implemented for IMGs to enhance English (e.g., English for medical purposes, English medium international project, and interdisciplinary collaboration using multimedia) and conceptual frameworks guiding teaching and learning in international multilingual environments (e.g., clinical communication skills and genre approach). Future directions in researching the teaching and learning of medical English as a lingua franca are suggested for practitioners teaching medical English for specific purposes, IMGs and prospective IMGs in international multilingual contexts and researchers specializing in interlingual medical communication.
HARNESSING ARTIFICIAL INTELLIGENCE WITH HIGHER EDUCATION IN VIETNAM
Authors: Nhung Doan Hong , Bao Nguyen Xuan , Ha Vu Thi Hong 
Published: December 2024

The purpose of the current research was to use artificial intelligence with higher education in Vietnam: opportunities, challenges and recommendations for legal undergraduate studies, Research method: the current library research method using articles from PubMed, Embase, Scopus databases., Medline and Web of Science using the keywords of artificial intelligence, higher education of Vietnam, was an expert in law. Results: The reviews of articles in the fields of artificial intelligence and higher education in educational fields, especially law in Vietnam, showed that in the present era, the use of artificial intelligence (AI) has become increasingly popular in Vietnam. Artificial intelligence is being used in higher education in general, and law schools show particular promise. However, this software has significant differences compared to other domains. Conclusion, according to the research results, we conclude that artificial intelligence offers many transformative opportunities for higher education in Vietnam. And by effectively using the power of artificial intelligence, Vietnamese universities can improve the quality of their educational offerings and align them with the evolving demands of society, uniting technology developers and students across Vietnam.