bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distractions in the cardiac catheterisation laboratory: impact for cardiologists and patient safety
Authors: Mahadevan Kalaivani , Cowan Elena , Kalsi Navneet , Bolam Helena , Arnett Richard , Hobson Alex , Guha Kaushik , Morton Geraint , Brennan Peter A , Kalra Paul R 
Published: December 2020

ObjectiveTo understand human factors (HF) contributing to disturbances during invasive cardiac procedures, including frequency and nature of distractions, and assessment of operator workload.MethodsSingle centre prospective observational evaluation of 194 cardiac procedures in three adult cardiac catheterisation laboratories over 6 weeks. A proforma including frequency, nature, magnitude and level of procedural risk at the time of each distraction/interruption was completed for each case. The primary operator completed a National Aeronautical and Space Administration (NASA) task load questionnaire rating mental/physical effort, level of frustration, time-urgency, and overall effort and performance.Results264 distractions occurred in 106 (55%) out of 194 procedures observed; 80% were not relevant to the case being undertaken; 14% were urgent including discussions of potential ST-elevation myocardial infarction requiring emergency angioplasty. In procedures where distractions were observed, frequency per case ranged from 1 to 16 (mean 2.5, SD ±2.2); 43 were documented during high-risk stages of the procedure. Operator rating of NASA task load parameters demonstrated higher levels of mental and physical workload and effort during cases in which distractions occurred.ConclusionsIn this first description of HF in adult cardiac catheter laboratories, we found that fewer than half of all procedures were completed without interruption/distraction. The majority were unnecessary and without relation to the case or list. We propose the introduction of a ‘sterile cockpit’ environment within catheter laboratories, as adapted from aviation and used in surgical operating theatres, to minimise non-emergent interruptions and disturbances, to improve operator conditions and overall patient safety.
Frontrunners in the race to develop a SARS-CoV-2 vaccine
Authors: Russell Raquel L. , Pelka Peter , Mark Brian L. 
Published: December 2020

Numerous studies continue to be published on the COVID-19 pandemic that is being caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Given the rapidly evolving global response to SARS-CoV-2, here we primarily review the leading COVID-19 vaccine strategies that are currently in Phase III clinical trials. Nonreplicating viral vector strategies, inactivated virus, recombinant protein subunit vaccines, and nucleic acid vaccine platforms are all being pursued in an effort to combat the infection. Preclinical and clinal trial results of these efforts are examined as well as the characteristics of each vaccine strategy from the humoral and cellular immune responses they stimulate, effects of any adjuvants used, and the potential risks associated with immunization such as antibody-dependent enhancement. A number of promising advancements have been made toward the development of multiple vaccine candidates. Preliminary data now emerging from phase III clinical trials show encouraging results for the protective efficacy and safety of at least 3 frontrunning candidates. There is hope that one or more will emerge as potent weapons to protect against SARS-CoV-2.
$$\omega \rightarrow 3\pi $$ and $$\omega \pi ^{0}$$ transition form factor revisited
Authors:   JPAC Collaboration, Albaladejo M. , Danilkin I. , Gonzàlez-Solís S. , Winney D. , Fernández-Ramírez C. , Blin A. N. Hiller , Mathieu V. , Mikhasenko M. , Pilloni A. , Szczepaniak A. 
Published: December 2020

AbstractIn light of recent experimental results, we revisit the dispersive analysis of the $$\omega \rightarrow 3\pi $$

ω
→
3
π

decay amplitude and of the $$\omega \pi ^0$$

ω

π
0

transition form factor. Within the framework of the Khuri–Treiman equations, we show that the $$\omega \rightarrow 3\pi $$

ω
→
3
π

Dalitz-plot parameters obtained with a once-subtracted amplitude are in agreement with the latest experimental determination by BESIII. Furthermore, we show that at low energies the $$\omega \pi ^0$$

ω

π
0

transition form factor obtained from our determination of the $$\omega \rightarrow 3\pi $$

ω
→
3
π

amplitude is consistent with the data from MAMI and NA60 experiments.
From the chair
Authors: West John 
Published: December 2020

In late July of this year, SIGHPC's main conference, Supercomputing (SC) 2020, announced that in light of the pandemic it would switch to a virtual meeting. Since our October issue is normally a preview of SC, we'll keep with tradition but highlight how several elements of the program have changed.
Of course, these unpredictable times mean a lot can still shift. So please be sure to monitor the SC20 website's Virtual Event FAQ page for updates.
Effect of Anacetrapib on Cholesterol Efflux Capacity: A Substudy of the DEFINE Trial
Authors: Metzinger Mark P. , Saldanha Suzanne , Gulati Jaskeerat , Patel Kershaw V. , El‐Ghazali Ayea , Deodhar Sneha , Joshi Parag H. , Ayers Colby , Rohatgi Anand 
Published: December 2020

Background
Anacetrapib is the only cholesteryl ester transfer protein inhibitor proven to reduce coronary heart disease (CHD). However, its effects on reverse cholesterol transport have not been fully elucidated. Macrophage cholesterol efflux (CEC), the initial step of reverse cholesterol transport, is inversely associated with CHD and may be affected by sex as well as haptoglobin copy number variants among patients with diabetes mellitus. We investigated the effect of anacetrapib on CEC and whether this effect is modified by sex, diabetes mellitus, and haptoglobin polymorphism.

Methods and Results

A total of 574 participants with CHD were included from the DEFINE (Determining the Efficacy and Tolerability of CETP Inhibition With Anacetrapib) trial. CEC was measured at baseline and 24‐week follow‐up using J774 macrophages, boron dipyrromethene difluoride–labeled cholesterol, and apolipoprotein B–depleted plasma. Haptoglobin copy number variant was determined using an ELISA assay. Anacetrapib increased CEC, adjusted for baseline CEC, risk factors, and changes in lipids/apolipoproteins (standard β, 0.23; 95% CI, 0.05–0.41). This CEC‐raising effect was seen only in men (
P
interaction=0.002); no effect modification was seen by diabetes mellitus status. Among patients with diabetes mellitus, anacetrapib increased CEC in those with the normal 1‐1 haptoglobin genotype (standard β, 0.42; 95% CI, 0.16–0.69) but not the dysfunctional 2‐1/2‐2 genotypes (
P
interaction=0.02).

Conclusions
Among patients with CHD, anacetrapib at a dose linked to improved CHD outcomes significantly increased CEC independent of changes in high‐density lipoprotein cholesterol or other lipids, with effect modification by sex and a novel pharmacogenomic interaction by haptoglobin genotype, suggesting a putative mechanism for reduced risk requiring validation.
Bankart Repair Versus Latarjet Procedure for Recurrent Anterior Shoulder Instability: A Systematic Review and Meta-analysis of 3275 Shoulders
Authors: Imam Mohamed A. , Shehata Mohamed S.A. , Martin Alexander , Attia Hamdy , Sinokrot Muhammad , Bahbah Eshak I. , Gwilym Stephen , Jacob Joshua , Narvani A. Ali , Meyer Dominik C. 
Published: December 2020

Background: Little consensus is available regarding the standard treatment for recurrent anterior instability of the shoulder. Typically, treatment selection has been based on training and tradition rather than the available evidence. Purpose: This study aimed to compare the clinical outcomes between arthroscopic Bankart procedure and the Latarjet procedure in the treatment of recurrent anterior shoulder instability with emphasis on follow-up time. Study Design: Systematic review and meta-analysis. Methods: We searched PubMed, Cochrane Central Register of Controlled Trials, Scopus, Ovid, and Web of Science up to January 2018 and included studies that compared arthroscopic Bankart versus Latarjet for treatment of anterior shoulder instability. Continuous data, such as operative time and patient-reported outcomes, were pooled as mean differences (MDs), whereas dichotomous data, such as recurrence, revision, redislocation, arthropathy, infection, and hematoma, were pooled as risk ratios (RRs), with 95% CIs. Results: Pooling data from 7 cohort studies (3275 patients) showed that arthroscopic Bankart was associated with a higher risk of redislocation (RR, 2.74; 95% CI, 1.48-5.06; P = .03), a higher risk of recurrence (RR, 2.87; 95% CI, 1.91-4.30; P < .0001), and a lower risk of infection (RR, 0.16; 95% CI, 0.06-0.43; P = .0002) compared with Latarjet, while the effect size did not favor arthroscopic Bankart or Latarjet in terms of Rowe score (MD, 0.22; 95% CI, –5.64 to 6.08; P = .94), revision (RR, 0.34; 95% CI, 0.08-1.39; P = .13), and hematoma (RR, 0.20; 95% CI, 0.03-1.19; P = .07). The effect estimate showed a pronounced advantage for Latarjet from 6 to 10 years postoperatively in terms of recurrence and redislocation (RR, 3.00; 95% CI, 1.98-4.56 and RR, 2.85; 95% CI, 1.51-5.38, respectively). Conclusion: Our results showed that Latarjet had less risk of recurrence and redislocation with longer follow-up time. Both procedures were comparable in terms of Rowe score, the need for revision, and postoperative hematoma formation, whereas Bankart repair was associated with a lower risk of infection.
Atypical periprosthetic femoral fractures of the hip: characterisation of three cases
Authors: Toro Giuseppe , Di Fino Ciro , De Cicco Annalisa , Toro Gabriella , Paoletta Marco , Toro Antonio , Tarantino Umberto , Iolascon Giovanni , Panni Alfredo Schiavone 
Published: December 2020

Introduction: Long-term use of bisphosphonates (BPs) has been associated with a specific type of tensile side femoral stress fracture known as Atypical Femoral Fracture (AFF). Theoretically periprosthetic femoral fractures (PFF) should be excluded from the diagnosis of AFF. However, emerging evidence correlates prolonged BPs use with the occurrence of a type of PFF with an atypical pattern (atypical PFF, APFF). The aim of the present study is to report 3 cases of APFF treated at a single centre. Methods: Clinical and radiographic records of PFF that occurred between January 2016 and August 2018 were retrospectively reviewed. All patients meeting the American Society for Bone and Mineral Research (ASBMR) criteria for definition of PFF were included. Management strategies for APFF and patient outcomes, including fracture healing and hip function (assessed by the Oxford Hip Score [OHS]) were collected. Results: 3 patients in the study period were identified as APFF (1 incomplete, 2 complete). All patients were females with a mean age of 83.3 years. All patients were treated with lateral plating. The application of a contralateral strut allograft resulted in fracture healing in cases of complete fractures. Mean OHS at final follow-up was 34.3. Conclusions: Despite occurring around a hip stem like PFF, APFF had peculiar clinical and radiographic features, making them more similar to AFF. Therefore, the orthopaedic surgeon should also consider the natural history and healing problems associated with AFF prior in order to choose the most appropriate management for APFF.
Knowledge and perceptions regarding triage among human papillomavirus–tested women: A qualitative study of perspectives of low-income women in Argentina
Authors: Victoria Sánchez Antelo , Racquel E Kohler , Lucila Szwarc , Melisa Paolino , Viswanath Kasisomayajula , Silvina Arrossi 
Published: December 2020

Objectives: Among cancer prevention studies, little is known about knowledge, attitudes, and beliefs toward triage adherence in the context of the human papillomavirus self-collection test. This formative research aims to identify knowledge, attitudes, and beliefs related to human papillomavirus and cervical cancer prevention specifically about adherence to Pap triage among women residing in a low-income province in Argentina. Methods: We conducted six focus groups, stratified by residence and age. All participants were aged 30 or older and had performed human papillomavirus self-collection. Data collection and thematic analysis were carried out using constructs from the Health Belief Model. Results: Misinformation regarding human papillomavirus and cervical cancer was common and was a source of distress. Women could not distinguish Pap screening from triage; human papillomavirus risk perception was limited but cervical cancer was perceived as a threatening disease. Women were willing to follow-up after receiving an abnormal screening result. Negative views about clinician-collected screening/triage were common, defined as painful and shameful, and comes with an economic cost (transport/time). Lack of help from family/friends was an obstacle to adhering to triage. Health issues in the family’s records and a physician’s recommendation were a cue to adhere to triage. Conclusion: Lack of knowledge or misinformation of the causes of cervical cancer, human papillomavirus, and the multi-step screening and triage process are barriers to follow-up adherence. Interventions to improve communication between women and health providers about screening results and follow-up are needed. Also, health services should be organized to respond to women’s needs and reduce access barriers to follow-up.
Single rotation CTA of extracranial carotids integrated with cerebral CTP provides sufficient quality for decision making in patients with ischaemic stroke
Authors: Wong Siong Chuong , Hausegger Klaus A , De Paoli Luca 
Published: December 2020

Purpose Large volume computed tomography scanners with 16 cm Z-axis single rotation coverage enable joggle-mode scanning of cerebral computed tomography perfusion and single rotation computed tomography angiography of cervical arteries. Our study aims to evaluate the feasibility of scanning cervical arteries, acquired with single rotation computed tomography angiography during computed tomography perfusion in ischaemic stroke patients. Materials and methods A total of 143 patients were scanned with a single contrast medium injection of 60 ml. Hounsfield units of the cervical arteries and veins were objectively measured and carotid bifurcations were subjectively reviewed. The incidence of artefacts and supra-aortic vessel coverage was recorded. Results Single rotation computed tomography angiography of the neck demonstrated supra-aortic vessels to their origins in 58 (40.6%) patients. Ninety-nine per cent (1140/1152) of arterial segments were adequately opacified (≥150 Hounsfield units). Arteries were adequately contrasted compared to veins in 81.3% (915/1126) of segments. However, the opacification was reversed in 14.0% (158/1126) of segments, indicating a delayed timing of acquisition; 95.5% (273/286) of carotid bifurcations were of good image quality. Measurement of internal carotid artery stenosis in single rotation computed tomography angiography according to the North American Symptomatic Carotid Endarterectomy Trial correlated well with digital subtraction angiography ( R=0.87, P<0.05). Significant artefacts resulted from metal/dental implants (10.5%), contrast in central veins (7.7%) and the shoulder region (4.9%). Conclusion Single rotation computed tomography angiography of the neck incorporated into cerebral computed tomography perfusion with single contrast medium administration revealed adequate image quality for further decision-making in our patient sample. The main drawbacks were inadequate coverage of supra-aortic arteries and possible delay in timing of the joggle.
Diversity of mangrove root-dwelling sponges in a tropical coastal ecosystem in the southern Gulf of Mexico region
Authors: Castellanos-Pérez Pedro de Jesús , Vázquez-Maldonado Laura Elena , Ávila Enrique , Cruz-Barraza José Antonio , Canales-Delgadillo Julio César 
Published: December 2020

AbstractSponges are one of the most conspicuous groups of epibionts in mangrove prop root habitats. However, with the exception of the Caribbean and the Indo-Pacific regions, studies focused on species diversity are lacking in other locations that have high mangrove coverage and are relatively distant from coral reef environments. Because mangrove-root epibiont communities, in general, have been understudied worldwide, this research contributes to filling this knowledge gap. In this study, a total of 30 sponge species (belonging to three subclasses, 14 families and 19 genera) were recorded as epibionts on prop roots of the red mangrove Rhizophora mangle in a tropical coastal ecosystem of the Southern Gulf of Mexico. Of these, five were new records for the Gulf of Mexico, 14 were new for the Mexican coasts of the gulf and 25 were new for the study area. Moreover, a similarity analysis based on presence/absence data of mangrove-associated sponges reported throughout the Western Central Atlantic region revealed that the sponge assemblage from the study area was more similar to those documented in most of the Caribbean locations (Jamaica, Cuba, Martinique, Panama, Venezuela, Belize and Colombia) rather than with those of the Northeast of the Gulf of Mexico, Guadeloupe and Trinidad. This relative intra-regional dissimilarity in the structure of mangrove-associated sponge assemblages may be related to differences in environmental conditions as well as taxonomic effort. The study area, unlike most of the Caribbean locations, is characterized by estuarine conditions and high productivity throughout the year. The inter-site variability recorded in the composition of mangrove-associated sponges was influenced by a set of factors such as salinity, dissolved oxygen and hydrodynamism. This study shows the importance of exploring the mangrove-associated sponge assemblages from different regions of the world as it furthers knowledge of the biodiversity and global distribution of this group.
Prevalence and factors associated with erectile dysfunction among adult men in Moshi municipal, Tanzania: community-based study
Authors: Nyalile Kenan B. , Mushi Emmanuel H. P. , Moshi Epiphania , Leyaro Beatrice J. , Msuya Sia E. , Mbwambo Orgeness 
Published: December 2020

AbstractBackgroundErectile dysfunction (ED) has a negative impact on ones’ relationships with poor quality of life as inevitable result. The effects of ED maybe worse in developing countries setting like Tanzania because men’s sexual health has been forgotten. Men’s sexual and reproductive health needs are not in the national reproductive health strategic. This study aimed to determine the prevalence and factors associated with erectile dysfunction among adult men in Moshi municipality, northern Tanzania.ResultsThe mean age of the 381 men was 39.6 (SD ±16.8) years. The overall prevalence of ED on this study was 29.7%. The severity of ED among study participants was; 13.4% (51), 9.7% (37), 3.7% (14), 2.9% (11) had mild, mild to moderate, moderate and severe erectile dysfunction respectively. Age 40–54 years (Adjusted OR 5.0, 95% CI 2.5–9.9),>55 years (aOR 11.7, 95% CI 5.8–23.7) and hypertension (aOR 2.6, 95% CI 1.1–6.4) were independent predictors of ED respectively.ConclusionThe prevalence of ED is high among men in Moshi municipal as 1 out of 3 men have ED. Age and hypertension were independent predictors of ED. These results point to the need of community awareness and education programs to raise awareness among men about existence of ED problem, its consequence and where they can get advice and care in this setting. Further, health providers taking care of hypertensive and men with DM should be equipped with knowledge and skills on early detection for ED and how to counsel and where to refer patients for help.
Metabolomic and transcriptomic analyses of mutant yellow leaves provide insights into pigment synthesis and metabolism in Ginkgo biloba
Authors: Wu Yaqiong , Guo Jing , Wang Tongli , Cao Fuliang , Wang Guibin 
Published: December 2020

Abstract
Background
Ginkgo (Ginkgo biloba L.) is an excellent landscape species. Its yellow-green leaf mutants are ideal materials for research on pigment synthesis, but the regulatory mechanism of leaf coloration in these ginkgo mutants remains unclear.

Results
We compared the metabolomes and transcriptomes of green and mutant yellow leaves of ginkgo over the same period in this study. The results showed that the chlorophyll content of normal green leaves was significantly higher than that of mutant yellow leaves of ginkgo. We obtained 931.52M clean reads from different color leaves of ginkgo. A total of 283 substances in the metabolic profiles were finally detected, including 50 significantly differentially expressed metabolites (DEMs). We identified these DEMs and 1361 differentially expressed genes (DEGs), with 37, 4, 3 and 13 DEGs involved in the photosynthesis, chlorophyll, carotenoid, and flavonoid biosynthesis pathways, respectively. Moreover, integrative analysis of the metabolomes and transcriptomes revealed that the flavonoid pathway contained the upregulated DEM (−)-epicatechin. Fourteen DEGs from the photosynthesis pathway were positively or negatively correlated with the DEMs.

Conclusions
Our findings suggest a complex metabolic network in mutant yellow leaves. This study will provide a basis for studies of leaf color variation and regulation.
Mapping and understanding the decision-making process for providing nutrition and hydration to people living with dementia: a systematic review
Authors: Anantapong Kanthee , Davies Nathan , Chan Justin , McInnerney Daisy , Sampson Elizabeth L. 
Published: December 2020

Abstract
Background
This systematic review aimed to explore the process of decision-making for nutrition and hydration for people living with dementia from the perspectives and experiences of all involved.

Methods
We searched CINAHL, the Cochrane Library, EMBASE, MEDLINE and PsycINFO databases. Search terms were related to dementia, decision-making, nutrition and hydration. Qualitative, quantitative and case studies that focused on decision-making about nutrition and hydration for people living with dementia were included. The CASP and Murad tools were used to appraise the quality of included studies. Data extraction was guided by the Interprofessional Shared Decision Making (IP-SDM) model. We conducted a narrative synthesis using thematic analysis. PROSPERO registration number CRD42019131497.

Results
Forty-five studies were included (20 qualitative, 15 quantitative and 10 case studies), comprising data from 17 countries and 6020 patients, family caregivers and practitioners. The studies covered a range of decisions from managing oral feeding to the use of tube feeding. We found that decisions about nutrition and hydration for people living with dementia were generally too complex to be mapped onto the precise linear steps of the existing decision-making model. Decision-making processes around feeding for people living with dementia were largely influenced by medical evidence, personal values, cultures and organizational routine. Although the process involved multiple people, family caregivers and non-physician practitioners were often excluded in making a final decision. Upon disagreement, nutrition interventions were sometimes delivered with conflicting feelings concealed by family caregivers or practitioners. Most conflicts and negative feelings were resolved by good relationship, honest communication, multidisciplinary team meetings and renegotiation.

Conclusions
The decision-making process regarding nutrition and hydration for people living with dementia does not follow a linear process. It needs an informed, value-sensitive, and collaborative process. However, it often characterized by unclear procedures and with a lack of support. Decisional support is needed and should be approached in a shared and stepwise manner.