bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced performance of dye-sensitized solar cell with thermally stable natural dye-assisted TiO2/MnO2 bilayer-assembled photoanode
Authors: Datta Shyamal , Dey Argha , Singha Nayan Ranjan , Roy Subhasis 
Published: November 2020

AbstractThis study reports the performance analysis of an organic dye-sensitized solar cell (DSSC), introducing MnO2 as an electron transport layer in TiO2/MnO2 bilayer assembly. The DSSCs have been fabricated using TiO2 and TiO2/MnO2 layer-by-layer architecture films onto fluorine-doped tin oxide (FTO) glass and sensitized with natural dye extracted from Malvaviscus penduliflorus flower in ethanol medium. The counter electrode was prepared to layer copper powder containing paste onto FTO's conductive side by the doctor's blade method. The optical, morphological, and structural properties of photoanodes were explored via ultraviolet–visible, field emission scanning electron microscopy, and X-ray diffraction analyses. Moreover, dye complexity and thermostability of dyes were characterized via Fourier-transform infrared spectroscopy and thermogravimetric analyses. The iodide/triiodide (i.e., I−/I3−) redox couple of electrolyte solution was employed as a charge transport medium between the electrodes. Finally, photoanode and counter electrode sandwiches were assembled to envisage the photovoltaic performance potential under simulated AM 1.5G solar illumination using 100 mW cm–2 light intensity. The as-fabricated DSSC comprising TiO2/MnO2 bilayer assembly exhibited 6.02 mA cm–2 short circuit current density (Jsc), 0.38 V open-circuit voltage (Voc), 40.38% fill factor, and 0.92% conversion efficiency, which is about 200% higher compared to the assembly devoid of MnO2 layer.
Embedded YARA rules: strengthening YARA rules utilising fuzzy hashing and fuzzy rules for malware analysis
Authors: Naik Nitin , Jenkins Paul , Savage Nick , Yang Longzhi , Boongoen Tossapon , Iam-On Natthakan , Naik Kshirasagar , Song Jingping 
Published: November 2020

AbstractThe YARA rules technique is used in cybersecurity to scan for malware, often in its default form, where rules are created either manually or automatically. Creating YARA rules that enable analysts to label files as suspected malware is a highly technical skill, requiring expertise in cybersecurity. Therefore, in cases where rules are either created manually or automatically, it is desirable to improve both the performance and detection outcomes of the process. In this paper, two methods are proposed utilising the techniques of fuzzy hashing and fuzzy rules, to increase the effectiveness of YARA rules without escalating the complexity and overheads associated with YARA rules. The first proposed method utilises fuzzy hashing referred to as enhanced YARA rules in this paper, where if existing YARA rules fails to detect the inspected file as malware, then it is subjected to fuzzy hashing to assess whether this technique would identify it as malware. The second proposed technique called embedded YARA rules utilises fuzzy hashing and fuzzy rules to improve the outcomes further. Fuzzy rules countenance circumstances where data are imprecise or uncertain, generating a probabilistic outcome indicating the likelihood of whether a file is malware or not. The paper discusses the success of the proposed enhanced YARA rules and embedded YARA rules through several experiments on the collected malware and goodware corpus and their comparative evaluation against YARA rules.
Amphiphilic peptide dendrimer-based nanovehicles for safe and effective siRNA delivery
Authors: Ma Chi , Zhu Dandan , Chen Yu , Dong Yiwen , Lin Wenyi , Li Ning , Zhang Wenjie , Liu Xiaoxuan 
Published: November 2020

AbstractSmall interfering RNA (siRNA)-based RNA interference has emerged as a promising therapeutic strategy for the treatment of a wide range of incurable diseases. However, the safe and effective delivery of siRNA therapeutics into the interior of target cells remains challenging. Here, we disclosed novel amphiphilic peptide dendrimers (AmPDs) that composed of hydrophobic two lipid-like alkyl chains and hydrophilic poly(lysine) dendrons with different generations (2C18-KK2 and 2C18-KK2K4) as nanovehicles for siRNA delivery. These AmPDs are able to self-assemble into supramolecular nanoassemblies that are capable of entrapping siRNA molecules into nanoparticles to protect siRNA from enzymatic degradation and promote efficient intracellular uptake without evident toxicity. Interestingly, by virtue of the optimal balance of hydrophobic lipid-like entity and hydrophilic poly(lysine) dendron generations, AmPD 2C18-KK2K4 bearing bigger hydrophilic dendron can package siRNA to form stable, but more ready to disassemble complexes, thereby resulting in more efficient siRNA releasing and better gene silencing effect in comparison with AmPD 2C18-KK2 bearing smaller dendron. Additional studies confirmed that 2C18-KK2K4 can capitalize on the advantages of lipid and peptide dendrimer vectors for effective siRNA delivery. Collectively, our AmPD-based nanocarriers indeed represent a safe and effective siRNA delivery system. Our findings also provide a new perspective on the modulation of self-assembly amphiphilic peptide dendrimers for the functional and adaptive delivery of siRNA therapeutics.
The Release Behavior, Biocompatibility and Physical Properties of Ald-loaded Strontium Doped Calcium Phosphate Cement
Authors: Mohammadi Maryam , Rabiee Sayed Mahmood , Hesaraki Saeed 
Published: November 2020

AbstractThe effect of concurrent attendance of two inhibitors of bone degradation, namely Alendronate (Ald) sodium trihydrate and Strontium (Sr), on Calcium Phosphate Cement (CPC) characteristics was explored. To this aim, 5 wt% Strontium and 21 mM Alendronate sodium trihydrate were used in calcium phosphate cement and setting time, ion and drug release were analyzed. RAW264.7 and G cell were cultured on cement samples and Tartrate-Resistant Acid Phosphatase (TRAP), Alkaline phosphatase (ALP) activity and MTT assay were studied. The results of structural analysis indicated that 21 mM Ald did not let the cement set. Therefore, colloidal silica was added to the cement formula and successfully decreased the setting time.In vitrotests showed Sr-loaded sample had a greater inhibitory effect on biocompatibility of G cells than Ald-loaded and Sr-Ald-loaded samples. In addition, the findings about osteoblast MTT and ALP activity indicated that Sr was more effective in osteogenic activity of G cells. The simultaneous presence of Ald and Sr in Calcium Phosphate Cement (CPC) was not as effective in its biocompatibility as the presence of Sr alone.
New Drug and Biologics Approvals in 2019: A Systematic Analysis of Patient Experience Data in FDA Drug Approval Packages and Product Labels
Authors: Schultz-Knudsen Katrine , Sabaliauskaite Ugne , Hellsten Johan , Lassen Anders Blaedel , Morant Anne Vinther 
Published: November 2020

Abstract
Background
The FDA Patient-Focused Drug Development Initiative was launched to ensure the incorporation of the patient voice into drug development and evaluation. Since 2017, the FDA must publish a statement outlining patient experience data (PED) considered in the approval of new drugs. This study investigated the presence and role of PED in drug approval and translation into product label claims.

Methods
PED reported in approval packages of the 48 drugs approved by FDA’s Center for Drug Evaluation and Research in 2019 was identified and categorized. PED in the form of clinical outcome assessments (COAs) was characterized by endpoint positioning and outcome. The product labels were analyzed for PED-related claims.

Results
PED was reported as relevant for 39 of 48 (81.3%) drugs approved in 2019. COAs were the predominant PED type; other PED was identified for only 9 (18.8%) drugs, and none included qualitative or patient preference studies. COAs were the only type of PED for which associated claims were identified in the product labels. 27 out of 48 (56.3%) labels contained one or more efficacy claims based on COAs; of these, patient-reported outcomes were the most prevalent with claims identified in 19 labels (39.6%).

Conclusion
There are ample opportunities for incorporating PED beyond COAs to inform drug development and facilitate availability of medicines tailored to patient needs. A higher level of transparency on the role of PED in regulatory decision-making and a clear path to PED-based label claims could incentivize sponsors and enable patient empowerment in treatment decisions.
Expressive Embodiment: Hegel, Habitual Agency and the Shortcomings of Normative Expressivism
Authors: Testa Italo 
Published: November 2020

AbstractIn this paper I tackle the normative re-appropriation of the legacy of Charles Taylor's expressivist understanding of Hegel's theory of action. I argue that a normative understanding of Hegel's expressivist notion of agency by interpreters such as Robert Pippin, Terry Pinkard, Michael Quante and Robert Brandom, has been obtained at the price of losing sight of the principle of embodiment and of its relevance for our and Hegel's understanding of social action. I aim at relocating Hegel's notion of expressive embodiment at the core of his explanation of action. Rather than following Taylor's hermeneutical reconstruction of the principle of embodiment, I try to reconstruct it by putting at its core the notion of habit formation with the help of conceptual tools taken from contemporary embodied cognition approaches. I first discuss theAnthropologyand argue that habit, understood as a sensorimotor embodied life form, is not only an enabling condition for agency, but in fact an ontological constitutive condition for all its levels of manifestation. According to this reading, the Hegelian approach to embodiment offers a model that not only assigns to habit a positive constitutive role in the formation of human mindedness, but also overcomes the dualism between habitual motor routine and intentional activities. If we approach Hegel's understanding of agency from this vantage point, we can gain a perspective which allows us to appreciate a naturalist strand of Hegel's expressivism about action and to free it from certain basic anti-naturalistic assumptions of contemporary normative expressivist interpretations of Hegel on social action.
A psychoeducational intervention increases use of a delirium protocol by Neurologists and Neurosurgeons in patients with brain disorders
Authors: Patel S. , Carey C. , Cotter D. , Murphy K. C. 
Published: November 2020

Objectives:Over 50% of inpatients with neurological disorders may present with a co-morbid psychiatric illness. Delirium has a reported point prevalence of 20% in hospital inpatients and is frequently undetected. We aimed to (1) examine inpatient referrals to a Liaison Neuropsychiatry service and (2) review the diagnosis and management of delirium before and after an educational intervention.Methods:An initial 6-month audit of referrals to the inpatient Liaison Neuropsychiatry service was conducted in 2018. We then undertook a psychoeducational intervention to raise awareness of the diagnosis and management of delirium. We conducted a re-audit of referrals to the service in 2019.Results:On initial audit, of 84 referrals, the most common referral was for mood (38%; n = 32). Just 4% (n = 3) had a specific delirium query. Following assessment by Neuropsychiatry, organic disorders (43%; n = 32), including delirium (33%; n = 25), were the most common diagnoses. On re-audit, of 86 referrals, mood assessment remained the most common reason for referral (38%; n = 33) and 2% (n = 2) were referred for possible delirium. Organic disorders remained the most common diagnoses (53%; n = 45) including delirium (38%; n = 32). We found a significant increase in the use of the delirium protocol from 12% (n = 3) on initial audit to 47% (n = 15); p < 0.01 on re-audit despite no increase in the number of specific delirium queries.Conclusions:A psychoeducational intervention improves the management of delirium by Neurologists and Neurosurgeons in patients with brain disorders.
Geomorphological evolution of the Petrovaradin Fortress Palaeolithic site (Novi Sad, Serbia)
Authors: Marković Slobodan B. , Vandenberghe Jef , Stevens Thomas , Mihailović Dušan , Gavrilov Milivoj B. , Radaković Milica G. , Zeeden Christian , Obreht Igor , Perić Zoran M. , Nett Janina J. , Lehmkuhl Frank 
Published: November 2020

AbstractTwo phases of archaeological investigation were performed in the Novi Sad City Museum at Petrovaradin Fortress. In this study, we summarize the results of geo-archaeological investigations of the second period of excavation inside the Novi Sad City Museum building. The fortress is situated on a Danube terrace with the top of the bedrock at ca.123 m asl. The investigated section consists of undisturbed fine-sandy silt. The grain-size distribution of the sediments indicates clearly its alluvial reworking but shows also a general similarity with typical primary loess in the region. All analyzed proxies indicate slightly stronger weathering in the upper part of the profile. Luminescence ages suggest that the investigated sequence covers the last glacial period and the terrace presumably formed during MIS 4. Subsequently, the Danube started its incision at the start of the next warmer period (MIS 3) onward. This terrace age and elevation enable us to derive an uplift rate of the terrace of ca. 0.73 mm/a for the last 60 ka, which seems to increase towards the present. Basal loessic material, in which artifacts occur, likely in the reworked position, indicate that the area close to today's Petrovaradin Fortress was already inhabited in MIS 5.
Peat Properties and Holocene Carbon and Nitrogen Accumulation Rates in a Peatland in the Xinjiang Altai Mountains, Northwestern China
Authors: Zhang Yan , Yang Ping , Gao Chuanyu , Tong Chuan , Zhang Xinyan , Liu Xingtu , Zhang Shaoqing , Meyers Philip A. 
Published: November 2020

AbstractA high‐resolution study of bulk properties in a peat sequence from the Xinjiang Altai Mountains of northwestern China has allowed reconstruction of local variations in peat properties and peat C and N accumulation rates (CAR and NAR) during the Holocene. Analyses of peat bulk density, loss on ignition, and concentrations of total organic carbon (TOC) and total nitrogen (TN) and their elemental ratios and stable isotopic values suggest that changes in peat‐forming vegetation types during different parts of this epoch are the major factors responsible for the variations of peat properties in this sequence. The long‐term peat CAR has been 25.4 ± 7.7 (SD) g C/m2/yr, with lower values during the early Holocene and higher accumulations during the late Holocene, which is opposite to the Holocene variations in CAR in other northern peatlands. In contrast, the long‐term peat NAR is 1.5 ± 0.5 (SD) g N/m2/yr and is higher during the early and middle Holocene and lower during the late Holocene as in other northern peatlands. However, unlike other northern peatlands, long‐term peat NAR does not vary with the CAR, which is influenced by the peat density and accumulation rate. Variations in long‐term peat C and N accumulations in the Altai Mountains can be attributed to changes in primary productivity, in the dominant plant types and in peat decomposition caused by changes in both regional Holocene climate and local conditions.
Comparing Flood Projection Approaches Across Hydro‐Climatologically Diverse United States River Basins
Authors: Schlef Katherine E. , François Baptiste , Brown Casey 
Published: November 2020

AbstractThe challenge of estimating design flood magnitude under climate change has led to the development of multiple approaches to long‐term flood projection: stationarity, informed‐parameter (composed of both trend informed and climate informed), and hydrologic simulation. This is the first study to compare these approaches across a large set of hydro‐climatologically diverse basins located throughout the contiguous United States, grouped into distinct clusters based on catchment and flood characteristics. The comparison is achieved using a split‐sample test conducted over the historic period; the climate (specifically, precipitation) informed and hydrologic simulation (specifically, Sacramento Soil Moisture Accounting model) approaches are forced with observations and downscaled general circulation model (GCM) simulations. The results provide a quantitative perspective on key long‐term flood projection issues. The precipitation informed approach can be informative for projections of regional change; the hydrologic simulation approach can be informative for direction of change for a single basin. When forced with GCM outputs, precipitation informed is both more accurate and more precise than hydrologic simulation, after accounting for model error. For hydrologic simulation, forcing with GCMs will add positive bias for basins in the Rocky Mountains and Southwest and will add negative bias with large uncertainty across GCMs for basins in the lower Midwest, the South, and the mid‐Atlantic seaboard. The results illustrate the need for continued improvement in long‐term flood projection approaches and for design paradigms incorporating uncertainty.
Distinguishing Variability Regimes of Hawaiian Summer Rainfall: Quasi‐Biennial and Interdecadal Oscillations
Authors: Luo Xiao , Wang Bin , Frazier Abby G. , Giambelluca Thomas W. 
Published: November 2020

AbstractSummer precipitation in Hawai'i accounts for 40% of the annual total and provides important water sources. However, our knowledge about its variability remains limited. Here we show that statewide Hawai'i summer rainfall (HSR) variability exhibits two distinct regimes: quasi‐biennial (QB, ~2 years) and interdecadal (~30–40 years). The QB variation is linked to alternating occurrences of the Western North Pacific (WNP) cyclone and anticyclone in successive years, which is modulated by the intrinsic El Niño–Southern Oscillation biennial variability and involves a positive feedback between atmospheric Rossby waves and underlying sea surface temperature (SST) anomalies. The interdecadal variation of HSR is largely modulated by the Pacific Decadal Oscillation through affecting upstream low‐level humidity that affects topographic rainfall. HSR shows weak long‐term drying trend during 1920–2019. This first description of the major physical drivers of summer rainfall variability provides key information for seasonal rainfall prediction in Hawai'i.
Formation of Igneous Layering in the Lower Oceanic Crust From the Samail Ophiolite, Sultanate of Oman
Authors: Mock D. , Neave D. A. , Müller S. , Garbe‐Schönberg D. , Namur O. , Ildefonse B. , Koepke J. 
Published: November 2020

AbstractAs the largest and best exposed example of paleo fast‐spreading oceanic crust on land, the Samail ophiolite in the Sultanate of Oman represents an ideal natural laboratory for investigating deep crustal processes at fast‐spreading mid‐ocean ridges. We studied two layered gabbro sequences from different stratigraphic depths: one from the middle of the plutonic crust showing decimeter‐scale modal layering (i.e., varying phase proportions) with olivine abundances gradually decreasing from layer bases to tops (Wadi Somerah, Sumail block) and one located near the crust‐mantle boundary showing millimeter‐scale olivine‐rich layers (Wadi Wariyah, Wadi Tayin block). Our multimethod approach of field, petrographic, geochemical, and microstructural observations focuses on documenting layered textures that are widely observed within the lower oceanic crust as well as understanding their formation mechanisms within the context of small scale crustal accretion processes beneath fast‐spreading mid‐ocean ridges. Results from the mid‐crustal sequence indicate moderate cooling rates (Ca‐in‐olivine: log[dT/dt; °C yr−1] = −2.21 ± 0.7) and correlated variations in mineral compositions and microstructures. We infer that decimeter‐scale layers in Wadi Somerah were deposited by density currents of crystal‐laden magma within a sill environment that potentially experienced occasional magma replenishment. The millimeter layering in Wadi Wariyah is best explained by Ostwald ripening emphasizing initial heterogeneities possibly being provoked by cyclical nucleation of olivine through the competing effects of element diffusion and rapid cooling. Fast cooling is recorded for the crustal base (Ca‐in‐olivine: log[dT/dt; °C yr−1] = −1.19 ± 0.5, Mg‐in‐plagioclase: log[dT/dt; °C yr−1] = −1.35°C ± 0.6) demonstrating that heat locally can be lost very efficiently from the lowermost crust.
Climate Variability Impacts on Global Extreme Wave Heights: Seasonal Assessment Using Satellite Data and ERA5 Reanalysis
Authors: Patra Anindita , Min Seung‐Ki , Seong Min‐Gyu 
Published: November 2020

AbstractThis study examines the influences of major climate variability modes on global extreme significant wave height (SWH) during 1992–2016 using merged satellite altimeter records and ERA5 reanalysis data set. El Niño‐Southern Oscillation (ENSO), North Atlantic Oscillation (NAO), North Pacific Oscillation (NPO), and Southern Annular mode (SAM) are considered during December–February (DJF), March–May (MAM), June–August (JJA), and September–November (SON). A nonstationary generalized extreme value analysis is applied to seasonal maxima of SWH (Hmax) to identify the regions with significant impacts of climate variability. In addition to major impacts over the northeastern North Pacific (NP) and Maritime Continent during DJF, signature of ENSO in Hmax is observed over the southeast South Pacific during all seasons associated with the Pacific South America pattern and over the western NP during JJA and SON through the El Niño‐East Asian teleconnection mechanism. Notable contribution of NAO to North Atlantic Hmax, resulting from north‐south movement of storm track, is observed during DJF and MAM. Increased Hmax is concentrated around the northeast NP during the positive phase of NPO during DJF, which accompanies Aleutian low strengthening and suggests possible combined influence with ENSO. SAM influences on Hmax are characterized by a zonal pattern in the Southern mid‐ and high latitudes around the year, with seasonally distinct zonal extent and meridional shifts. Overall, the satellite and reanalysis data exhibit consistent results. Hmax responses are generally in accord with extreme wind and sea‐level pressure gradient amplitude, supporting the wind‐driven extreme wave mechanisms.