bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effektivität stationär-psychosomatischer Behandlung:
Kurz- und mittelfristige klinische und versorgungsbezogene
Effekte
Authors: Valdes-Stauber Juan , Beck Alexandra , Krämer Sabine , Bachthaler Susanne 
Published: April 2020

Zusammenfassung
Fragestellung Hält die durch stationär-psychosomatische
Behandlung erreichte klinische Besserung ein bzw. 2 Jahre nach der Entlassung
an? Wie verändert sich die medizinische Inanspruchnahme nach der
Entlassung verglichen mit dem Jahr vor der stationär-psychosomatischen
Behandlung?
Methode Die einwilligende Stichprobe zum Entlasszeitpunkt (N=250)
wird anhand von 6 klinischen, 2 ressourcenbezogenen und 11
versorgungsmedizinischen Variablen zu 6 Messzeitpunkten (Aufnahme, Entlassung
und jeweils 6, 12, 18, 24 Monate nach Entlassung) untersucht. Die
adhärente Teilstichprobe (n=86) und die nicht adhärente
(n=164) Teilstichprobe werden anhand von 25 Variablen verglichen. Der
Verlauf der Zielvariablen wird graphisch anhand von Box-Plots dargestellt.
Bivariate Vergleiche werden mit Mann-Withney-, Wilcoxon- und t-Tests mit
Bonferroni-Korrektur durchgeführt, Vergleiche aller Messzeitpunkte
für die Zielvariablen unter statistischer Kontrolle mit
ausgewählten Kovariaten anhand von multivariaten
Random-Effects-Regressionsmodellen unter Einsatz von multipler Imputation
für Zeitreihen (MICE).
Ergebnisse Die adhärente und die nichtadhärente
Teilstichprobe unterscheiden sich kaum nach Korrektur der Alpha-Inflation. Zwei
Jahre nach der Entlassung sind bei der adhärenten Teilstichprobe alle
Zielvariablen im Vergleich zum Aufnahmezeitpunkt signifikant gebessert
(p<0,001; durchschnittliche Gesamteffektstärke 1,12). Psychische
Symptombelastung und Depressivität haben nach der Entlassung weiter
signifikant abgenommen, Selbstwirksamkeit und Lebenszufriedenheit haben
signifikant zugenommen. In bivariaten Modellen sinken Krankenhaustage,
Arbeitsunfähigkeitstage, Arztbesuche und Medikation ein und 2 Jahre nach
der Entlassung verglichen mit dem Jahr vor der Aufnahme. Multivariate Modelle
mit der Gesamtstichprobe zum Entlasszeitpunkt bestätigen den positiven
Verlauf der klinischen Variablen, zeigen jedoch geringere Unterschiede
für die versorgungsmedizinischen Variablen.
Diskussion Die Limitation durch progressive Dropouts zeigte sich unter
dem Einsatz multipler Imputation verringert. Die anhaltende klinische Besserung
und die Verringerung der medizinischen Inanspruchnahme 2 Jahre nach der
Entlassung sprechen für eine mittelfristige Effektivität der
stationären psychosomatischen Behandlung. Strukturniveau der
Persönlichkeitsorganisation und Neurotizismus sind die besten
Prädiktoren für Ausmaß der psychischen Belastung
über alle Messzeitpunkte hinweg.
Safety and Tolerability of the Anxiolytic and Nootropic Drug Phenibut: A Systematic Review of Clinical Trials and Case Reports
Authors: Kupats Einars , Vrublevska Jelena , Zvejniece Baiba , Vavers Edijs , Stelfa Gundega , Zvejniece Liga , Dambrova Maija 
Published: April 2020

AbstractPhenibut is a nootropic drug that exerts anxiolytic and antinociceptive effects by acting on the GABAB receptor and the α2-δ subunit of voltage-dependent calcium channels. An increased number of reports of dependence to and intoxication by phenibut purchased online on the one hand and the wide prescription of phenibut in Eastern Europe for more than half a century on the other hand have resulted in a number of controversies regarding its use. In this review, we have summarized currently available information from case reports of phenibut dependence and intoxication and safety data from clinical trials. We included 14 dependence and intoxication case reports (16 patients) and reviewed 11 phenibut clinical trials (583 patients). The clinical symptoms in the case reports included cardiovascular effects, insomnia, anxiety and agitation, hallucinations, and depressed level of consciousness. In addition, the doses used (0.5–100 g/day) were much higher than the recommended daily dose (0.25–2 g/day). An analysis of phenibut side effects described in the clinical trials showed adverse events in only 5.66% of patients, and the most reported side effect was somnolence (1.89%). There are discrepancies in the reported side effects of phenibut in clinical trials compared to those reported in cases of online-purchased phenibut dependence and intoxication. The current systematic review provides evidence that, at therapeutic doses, phenibut is safe and well tolerated with minor adverse effects, but questions regarding the quality of phenibut obtained online and the contribution of alcohol and other drug abuse to phenibut dependence and intoxication remain open.
Psychische Belastung und Resilienz im Rahmen schwerer körperlicher Erkrankungen: eine Analyse dyadischer Zusammenhänge
Authors: Rosendahl Jenny , Jaenichen Doreen , Schmid Selina , Färber Francesca , Strauß Bernhard 
Published: April 2020

Zusammenfassung
Ziele In diesem Beitrag werden 3 Studien vorgestellt, in denen Patienten mit einer aktuellen oder vergangenen schweren körperlichen Erkrankung und ihre Partner in Hinblick auf dyadische Konkordanz sowie Geschlechts- und Rollenunterschiede in psychischer Belastung und Resilienz untersucht worden sind.
Methoden In Studie 1 wurden 55 Patienten und deren Partner im Mittel 4,5 Jahre nach einer schweren Sepsis untersucht. Studie 2 berücksichtigte 49 Lungenkrebspatienten, mehrheitlich im metastasierenden Tumorstadium, und ihre Partner. In Studie 3 wurden 69 Krebspatienten mit unterschiedlichen Tumorentitäten und Tumorstadien, die sich einer ambulanten homöopathischen Zusatzbehandlung unterzogen, und ihre Partner eingeschlossen. Zur Erfassung der psychischen Belastung wurde in allen Studien die Hospital Anxiety and Depression Scale (HADS) und zur Messung von Resilienz als Persönlichkeitsmerkmal die Kurzform der Resilienzskala RS-13 eingesetzt. Die jeweiligen Befunde wurden über die 3 Studien hinweg meta-analytisch zusammengefasst.
Ergebnisse Es zeigte sich eine dyadische Konkordanz zwischen Patient und Partner hinsichtlich Angst (r=0,29 [0,06; 0,48], I2=55%) und Depressivität (r=0,44 [0,31; 0,55], I2=0%), nicht jedoch für Resilienz. Geschlechtsunterschiede zeigten sich für Angst konsistent über alle 3 Studien hinweg, sowohl Patientinnen als auch Partnerinnen wiesen eine stärkere Angstsymptomatik auf als Patienten und Partner (d=0,58 [0,26; 0,91], I2=0% für Patienten; d=0,53 [− 0,06; 1,12], I2=69% für Partner). Heterogene Befunde lagen dagegen für Geschlechtsunterschiede in der Depressivität als auch für Rollenunterschiede vor. Eine höher ausgeprägte Resilienz geht mit geringerer psychischer Belastung sowohl bei Patienten als auch bei Partnern einher. Darüber hinaus gibt es Hinweise, dass Resilienz auch einen protektiven Effekt für die psychische Belastung des Partners haben kann.
Diskussion und Schlussfolgerung Basierend auf den vorliegenden Erkenntnissen zu dyadischen Zusammenhängen in der psychischen Belastung zwischen Patienten und deren Partnern sollten körperliche Erkrankungen grundsätzlich immer aus systemischer Perspektive betrachtet werden. Die psychische Belastung sowohl von Patienten als auch von deren Partnern bedarf einer besonderen Beachtung im psychosozialen Unterstützungsprozess, ebenso sollten partnerschaftliche Ressourcen in der Bewältigung der Erkrankung Berücksichtigung finden.
DIAGNOSTIC HYSTEROSCOPY IN ABNORMAL UTERINE BLEEDING & IT'S HISTOPATHOLOGIC CORRELATION: OUR EXPERIENCE
Authors: Nandan Neetha , Manjeera Lakshmi , Rai Supriya , Gowri Mangala 
Published: April 2020

Abstract
Aims & objectives: 1) To study the accuracy of hysteroscopy in evaluation of abnormal uterine bleeding in perimenopausal and postmenopausal women. 2) To correlate hysteroscopic findings with histopathologic results.
Materials and methods: It is a retrospective study done in the department of OBG at K. S.Hegde Medical Academy, Mangalore. All patients who underwent diagnostic hysteroscopy for abnormal uterine bleeding in the past 6 years were included in this study. Patients underwent clinical and sonographical evaluation. Following hysteroscopic evaluation, patients had undergone dilatation and curettage and endometrial curetting were sent for histopathological examination (HPE). The correlation between findings on hysteroscopy & HPE were tabulated.
Results: On hysteroscopy, endometrium was classified as suggestive of normal, hyperplasia, atrophic, polyp, fibroid, cancer. Histopathological diagnosis was taken as gold standard to determine the efficacy of hysteroscopy in diagnosing endometrial pathologies. Out of 175 patients, 108 patients were diagnosed to have endometrial hyperplasia on hysteroscopy, however only 53 confirmed to have on histopathologically. Similarly 25 patients were said to have normal findings on hysteroscopy but by histopathology 85 were having normal endometrium. Hysteroscopy was highly specific for diagnosis of polyp (95.9%), cancer (100.0%), and atrophy (96. 9%), normal endometrium (92.2%) but low specificity for diagnosing hyperplasia (48.4%). The sensitivity of hysteroscopy in diagnosing polyp and endometrial hyperplasia were 100% and 84.9% respectively but it was low in case of cancer (16.7%) and normal endometrium (21.2%).
Conclusion: Hysteroscopy is a highly accurate diagnostic tool in diagnosing intrauterine lesions like endometrial polyp and submucous fibroid. In fact, it was also found to be highly specific in conditions like endometrial cancer, polyp, atrophic and normal endometrium.
TRENDS OF POISONING AMONG CHILDREN AT KASTURBA HOSPITAL, MANIPAL
Authors: Tarvadi Pratik Vijay , Bakkannavar Shankar M. , S. Manjunath , Palimar Vikram , Kumar G. Pradeep , Shetty Mahabalesh 
Published: April 2020

Abstract
Background: Pediatric poisoning is a common medical emergency and also associated with a high morbidity and mortality in children. In developing countries like India, poisoning emergencies are becoming a major cause of mortality in infants and toddlers. Among the various studies conducted on poisoning in our country, the study on poisoning is predominantly on adults and hence this study is taken up to understand the incidence of childhood poisoning cases.
Method: A ten year retrospective study from January 1999 to December 2008 was conducted at the Department of Forensic Medicine & Toxicology, Kasturba Medical College, Manipal, to comprehend the magnitude of childhood poisoning cases at Kasturba Hospital, Manipal.
Results: Insecticide poisoning was the most predominant poisoning followed by venomous bites.
Conclusion: Our study examines the most common poison involved and route of intake among children to identify specific ages at risk and give suggestions so as to reduce the morbidity and mortality.
VALIDATION METRICS OF THE MASTOID TRIANGLE
Authors: B. Bhagya , N. Hema , A. Ramakrishna 
Published: April 2020

AbstractThe purpose of this study was to validate the technique developed by Paiva and Segre for sex identification using the mastoid process. Total mastoid area is calculated by adding the right and left triangular areas defined by three distinct craniometric points: the Asterion, Porion and the Mastoidale. Eight skulls (40 males and 40 females) were analysed and total area calculated using Heron's formula. The mean total area of the male skulls is higher compared to females (1461.06 mm2 vs 1222.79 mm2). Independent t-tests reveal that there are significant differences between males and females, with p-values less than 0.0001.
KNOWLEDGE REGARDING RCH SERVICES AMONG HEALTH WORKERS, PREGNANT MOTHERS AND ADOLESCENTS IN RURAL FIELD PRACTICE AREA
Authors: Rashmi Anusha , Kiran N. Udaya ,   Rashmi
Published: April 2020

AbstractMaternal mortality and morbidity are significant health problems in developing countries. Improving maternal health has been an essential element for achieving health for all and has been included in MDG to be achieved by 2010. Apart from mothers and children, the health of adolescents came into light as one of the important area mainly because of their role as future or immediate mothers. Role of health care providers especially the grass root level workers becomes particularly important not just in imparting the intending services, but also in imparting knowledge about reproductive health.To assess the knowledge about RCH services among the health care workers, pregnant women, mothers and adolescent girls.A cross sectional study was conducted in the rural field practice areas of K. S. Hegde Medical Academy. A total of 37 health workers, 50 pregnant women and mothers and 56 adolescents were interviewed using a pre tested questionnaire for assessing their knowledge regarding RCH services. Descriptive statistics was used in the analysis.Knowledge regarding high risk pregnancy identification, normal birth weight and identifying anaemia in the field was good among health workers. Only 10.8% of them knew the minimum strength of medical officers in a FRU and only 5.4% knew about fast breathing in less than 2 months old infant. With regard to mothers knowledge 64% were aware of the number of ANC visits, 44% knew about correct interval between 2 pregnancies, 38% knew about methods to prevent STI transmission. 82% of adolescents had good knowledge regarding legal age for marriage. 75% were aware of various methods of contraception.
MENOPAUSAL TRANSITION AMONG NORTHERN INDIAN WOMEN
Authors: S. Vijayalakshmi , Chandrababu Ramesh , L. Eilean Victoria 
Published: April 2020

AbstractAccording to Indian menopause society research there are about 65 million Indian women over the age of 45. Average age of menopause in around 48 yrs but it strikes Indian women as young as 30-35 years.The main aim of the study is to assess the menopausal transition among women residing at selected rural community, Punjab. The study was conducted from July 2012 to December 2012.The sample from the selected rural community and the research design used for this study was Non experimental design – descriptive survey method. The sample size selected for this study consists of 30 rural women 40-55 years of age from selected rural community at Amritsar. Purposive sampling method was used to select the samples. The tool used in this study was ZEG Berlin menopause rating scale to assess the menopausal transition. The data analysis was done using both descriptive and inferential statistics.The results reported that more prevalent symptoms were feeling tired (92.90%), headache (88.80%), joint and muscular discomfort (76.20%), physical and mental exhaustion (60.09%), sleeplessness (54.40%), depressive mood (37.30%), irritability (36%), dryness of vagina (36%), hot flushes and sweating (35.80%) and anxiety (34.50%).The rural women of Amritsar, Punjab experience high prevalence of menopausal symptoms. The high percentage and scores of MRS were observed in perimenopausal and postmenopausal women.
FABRICATION OF SINGLE PIECE HOLLOW BULB INTERIM OBTURATOR WITH PALATAL RAMP FOR TREATMENT OF HEMIMAXILLECTOMY AND HEMIMANDIBULECTOMY - A CASE REPORT
Authors: D. Anupama Prasad , D. Krishna Prasad , Hegde Chethan 
Published: April 2020

AbstractA male patient aged 45 years reported with squamous cell carcinoma of palate. Patient was seen presurgically and an immediate surgical obturator provided followed by an interim maxillary obturator by a novel method wherein hollowing the obturator bulb was planned which also had a palatal ramp to correct jaw relation lost due to hemimandibulectomy.The treatment was done in sequential order to correct the deviation of mandible to provide aesthetics to the subject and also for a comfortable social life with improved mastication and appearance.
BIOFILMS PRODUCED BY CANDIDA YEASTS AND ITS CONSEQUENCES: A REVIEW
Authors: D. Anupama Prasad , Prasad B. Rajendra , Shetty Veena , Shastry C.S 
Published: April 2020

AbstractThis paper aimed to gather information regarding mechanism of biofilm formation and development of resistance of the fungi mainly the candida species to antifungal therapy from literature through 1996-2012. We have carried out a detailed search in the National Library of Medicine's PubMed database, Google search and Science Direct to include all studies and reviews published in English language. The key words used for the search were biofilm, Candida, antimicrobial resistance, denture stomatitis and Candidiasis. This paper tries to explain the mechanism of biofilm formation, factors which initiate and propagate biofilm production and certain special features like thigmotropism and quorum sensing which are responsible for development of resistance in these yeasts.
Correction of Carpal Valgus and Flexural Deformity with z-Tenotomy and Anastomosis Procedure in a Dog
Authors: Gondolfe Mikaela , Garneau Mark 
Published: April 2020

AbstractThis study aimed to describe a staged bilateral z-tenotomy and anastomosis procedure of flexor carpi ulnaris and superficial digital flexor tendons for the correction of carpal valgus and flexural deformity in a 1-year-old male-neutered Akita dog. Bilateral carpal valgus and flexural deformity were observed with palpably taut flexor carpi ulnaris tendons. The dog had a mild, weight-bearing bilateral forelimb lameness with the left forelimb more severely affected. Both forelimbs were treated with staged z-tenotomy and anastomosis procedure of both flexor carpi ulnaris and superficial digital flexor tendons. Successful tendon lengthening and correction of carpal valgus were achieved via z-tenotomy and anastomosis of affected tendons. No complications were observed. An 18-month follow-up revealed no evidence of lameness or carpal valgus. Though tendon injuries commonly occur in small animal patients, there is a shortage of reported cases, especially involving musculotendinous contractures. There are even fewer reports of successful tenotomy procedures. This case report supports successful outcome of the z-tenotomy procedure in a canine patient.
High-energy ion (He+, Si++, Ga+, Au++) interactions with PMMA in ion beam lithography
Authors: Zhang Lei , Thomas Joseph P , Guan Xiaoyi , Heinig Nina F , Leung Kam Tong 
Published: April 2020

Abstract
Resist-based ion beam lithography has been studied by exposing different species of ions (He+, Si++, Ga+ and Au++) on 700 and 2000 Å thick poly(methyl methacrylate) (or PMMA) films supported on Si substrates. By comparing the resist sensitivities to different ions and the cross-sectional shapes of the developed features with the simulation outputs from the TRIM (TRansport of Ions in Matter) software, long-chain scissoring in PMMA can be largely attributed to ion-initiated electron cascades (as evaluated by ion energy loss to the electrons) and recoil atom cascades (as evaluated by vacancy distribution in TRIM). The ion-initiated electron cascades contribute more to the resist sensitivity for the lighter ions, while the recoil atom cascades are more important for the heavier ions. A proportional relation between the resist sensitivity and the product of the ion energy loss to electrons and vacancy number is obtained semi-empirically for heavy ions. The He+ ion is the only ion species that can travel through and therefore expose the entire 2000-Å thick PMMA resist film, while the heaviest ion, Au++, provides the highest resist sensitivity. The effective energy and momentum impartment to the resist by the ion, as revealed by recoil atom cascades and vacancy formation, is important to significantly expanding the material types suitable for ion beam lithography.
Efficient photocatalytic inactivation of E. coli by Mn-CdS/ZnCuInSe/CuInS2 quantum dots-sensitized TiO2 nanowires
Authors: Geng Hongchao , Jiang Ning , Li Chenyi , Zhu Xingqi , Qiao Yan , Cai Qingyun 
Published: April 2020

Abstract
A novel visible light-driven photocatalyst (represented as Mn-CdS/ZCISe/CIS/TiO2) for the passivation of E. coli was prepared with TiO2 nanowires as support and using CuInS2 (CIS) and ZnCuInSe (ZCISe) quantum dots (QDs), as well as Mn-doped CdS (Mn-CdS) nanoparticles (NPs) as sensitizers. The use of CIS and ZCISe QDs and Mn-CdS NPs extends the light harvest region to visible light. The photoelectric conversion efficiency was consequently improved, with a photocurrent density of 12.5 mA cm−2, about 60 times that of pure TiO2 nanowires. The germicidal efficiency of the photocatalyst was assessed by passivation of E. coli, 96% bacteria in 50 ml 105 colony forming units (CFU) ml−1 solution were killed within 50 min. Besides the high efficiency, the composite has good stability and satisfactory recycling performance. The antibiotic mechanism was also performed by using photoluminescence and a scavenging agent of different active matter, revealing that the photo-generated holes play a major role in the sterilization process.
Projection micro stereolithography based 3D printing and its applications
Authors: Ge Qi , Li Zhiqin , Wang Zhaolong , Kowsari Kavin , Zhang Wang , He Xiangnan , Zhou Jianlin , Fang Nicholas X 
Published: April 2020

Abstract
Projection micro stereolithography (PμSL) is a high-resolution (up to 0.6 μm) 3D printing technology based on area projection triggered photopolymerization, and capable of fabricating complex 3D architectures covering multiple scales and with multiple materials. This paper reviews the recent development of the PμSL based 3D printing technologies, together with the related applications. It introduces the working principle, the commercialized products, and the recent multiscale, multimaterial printing capability of PμSL as well as some functional photopolymers that are suitable to PμSL. This review paper also summarizes a few typical applications of PμSL including mechanical metamaterials, optical components, 4D printing, bioinspired materials and biomedical applications, and offers perspectives on the directions of the further development of PμSL based 3D printing technology.
What We Talk About When We Talk About Binge Drinking: Towards an Integrated Conceptualization and Evaluation
Authors: Maurage Pierre , Lannoy Séverine , Mange Jessica , Grynberg Delphine , Beaunieux Hélène , Banovic Ingrid , Gierski Fabien , Naassila Mickaël 
Published: April 2020

AbstractRationaleBinge drinking (BD), characterized by recurring alternations between intense intoxication episodes and abstinence periods, is the most frequent alcohol consumption pattern in youth and is growing in prevalence among older adults. Many studies have underlined the specific harmful impact of this habit by showing impaired abilities in a wide range of cognitive functions among binge drinkers, as well as modifications of brain structure and function.AimsSeveral controversies and inconsistencies currently hamper the harmonious development of the field and the recognition of BD as a specific alcohol consumption pattern. The main concern is the absence of consensual BD conceptualization, leading to variability in experimental group selection and alcohol consumption evaluation. The present paper aims at overcoming this key issue through a two-step approach.Methods and conclusionsFirst, a literature review allows proposing an integrated BD conceptualization, distinguishing it from other subclinical alcohol consumption patterns. Six specific characteristics of BD are identified, namely, (1) the presence of physiological symptoms related to BD episodes, (2) the presence of psychological symptoms related to BD episodes, (3) the ratio of BD episodes compared to all alcohol drinking occasions, (4) the frequency of BD episodes, (5) the consumption speed and (6) the alternation between BD episodes and soberness periods. Second, capitalizing on this conceptual clarification, we propose an evaluation protocol jointly measuring these six BD characteristics. Finally, several research perspectives are presented to refine the proposed conceptualization.