bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dysregulation of CO2-Driven Heart-Rate Chemoreflex Is Related Closely to Impaired CO2 Dynamic Vasomotor Reactivity in Mild Cognitive Impairment Patients
Authors: Marmarelis Vasilis Z. , Shin Dae C. , Zhang Rong 
Published: April 2020

Background: Significant reduction of dynamic vasomotor reactivity (DVR) was recently reported in patients with amnestic mild cognitive impairment (MCI) relative to age-matched controls. These results were obtained via a novel approach that utilizes data-based predictive dynamic models to quantify DVR. Objective: Using the same methodological approach, we seek to quantify the dynamic effects of the CO2-driven chemoreflex and baroreflex upon heart-rate in order to examine their possible correlation with the observed DVR impairment in each MCI patient. Methods: The employed approach utilizes time-series data to obtain subject-specific predictive input-output models of the dynamic effects of changes in arterial blood pressure and end-tidal CO2 (putative “inputs”) upon cerebral blood flow velocity in large cerebral arteries, cortical tissue oxygenation, and heart-rate (putative “outputs”). Results: There was significant dysregulation of CO2-driven heart-rate chemoreflex ( p = 0.0031), but not of baroreflex ( p = 0.5061), in MCI patients relative to age-matched controls. The model-based index of CO2-driven heart-rate chemoreflex gain (CRG) correlated significantly with the DVR index in large cerebral arteries ( p = 0.0146), but not with the DVR index in small/micro-cortical vessels ( p = 0.1066). This suggests that DVR impairment in small/micro-cortical vessels is not mainly due to CO2-driven heart-rate chemoreflex dysregulation, but to other factors (possibly dysfunction of neurovascular coupling). Conclusion: Improved delineation between MCI patients and controls is achieved by combining the DVR index for small/micro-cortical vessels with the CRG index ( p = 2×10–5). There is significant correlation ( p < 0.01) between neuropsychological test scores and model-based DVR indices. Combining neuropsychological scores with DVR indices reduces the composite diagnostic index p-value ( p∼10–10).
The Efficacy of COGnitive tRaining in patiEnts with Amnestic mild coGnitive impairmENT (COG-REAGENT): Protocol for a Multi-Center Randomized Controlled Trial
Authors: Xing Yi , Zhu Zude , Du Yifeng , Zhang Junjian , Qu Qiumin , Sun Li , Li Yang , Guo Yanjun , Peng Guoping , Liu Yong , Yu Yueyi , Qiao Yuchen , Xie Beijia , Shi Xinrui , Lu Jie , Jia Jianping , Tang Yi 
Published: April 2020

Background: Amnestic mild cognitive impairment (aMCI) is often the prodromal stage of Alzheimer’s disease (AD). Although previous studies have suggested that computerized cognitive training is an effective non-pharmacological intervention for aMCI, large-sample, randomized controlled studies are warranted to provide a high level of evidence. Objective: To identify the efficacy of computerized cognitive training for aMCI. Methods: This study will include 260 patients diagnosed with aMCI from 8 centers in China. A computerized multi-domain adaptive training program will be used in this study, and the targeted cognitive domains include memory, attention, language, and executive function. The patients will be randomized into either a cognitive-training group or an active-control group. The intervention is a 12-week internet-based cognitive training performed for 40 minutes per day, 4 days a week. Neuropsychological assessments and structural and functional MRI will be obtained at baseline, at the end of the intervention, and 6 months after randomization. The primary outcome will be the global cognitive function score assessed by Montreal Cognitive Assessment. The secondary outcomes include changes in other neuropsychological assessments and neuroplasticity changes measured by structural and functional MRI. Results: The trial is currently ongoing, and it is anticipated that recruitment will be completed in December 2020. Conclusion: This multi-center, large-sample, randomized controlled trial will investigate the short and long-term effects of computerized cognitive training in patients with aMCI. Furthermore, the combination of functional and structural MRI results will also reveal the underlying mechanisms of the effect of intervention.
High Plasma Resistin Levels Portend the Insulin Resistance-Associated Susceptibility to Early Cognitive Decline in Patients with Type 2 Diabetes Mellitus
Authors: Wang Chenchen , Huang Xi , Tian Sai , Huang Rong , Guo Dan , Lin Hongyan , Wang Jiaqi , Wang Shaohua 
Published: April 2020

Background: Metabolic disorders, including insulin resistance, obesity, and hyperlipidemia occur frequently prior to hyperglycemia in patients with type 2 diabetes mellitus (T2DM) and cause mild cognitive impairment (MCI). Objective: We investigated the involvement of resistin in these metabolic abnormalities contributes to MCI in patients with T2DM. Methods: A total of 138 hospitalized patients with T2DM were enrolled and categorized into MCI and non-MCI groups according to the Montreal Cognitive Assessment (MoCA) score. Metabolic indicators and cognitive state were assessed, and plasma resistin levels were determined by ELISA. Results: The resistin levels and homeostasis model assessment of insulin resistance (HOMA-IR) scores of MCI and gender-stratified subgroups were significantly higher than those of controls without MCI (all p < 0.01). Correlation analysis showed that the resistin level was negatively associated with majority of cognitive domains, e.g., MoCA ( r = –0.693, p < 0.001) and Mini-Mental State Examination ( r = –0.571, p < 0.001), and was related to HOMA-IR ( r = 0.667, p < 0.001) but not to obesity and lipid indices. Multivariable regression analysis indicated that resistin ( β= –0.675, p < 0.001) and educational level ( β= 0.177, p = 0.003) were independent risk factors of MoCA in patients with T2DM. Conclusions: High plasma resistin levels portend the insulin resistance-related susceptibility to early cognitive decline in Chinese patients with T2DM. The involvement of this adipokine in other metabolic disorders leading to diabetic MCI and its clinical value for early disease screening must be further studied.
Combination percutaneous and medical management of cardiac rhabdomyomas obstructing tricuspid valve inflow: Case report
Authors: Knadler J.J. , Lawrence E. , Iacobas I. , Justino H. , Sheth S. 
Published: April 2020

BACKGROUND: Cardiac rhabdomyomas can be prenatally diagnosed in patients with tuberous sclerosis complex. Many neonates require no intervention in early life other than close monitoring for regression of tumor over the period of months to years. In rare instances, cardiac rhabdomyomas can result in obstruction to blood flow or decreased ventricular function. CASE REPORT: We describe the case of a neonate who was prenatally diagnosed with multiple large cardiac rhabdomyomas, one of which caused clinically significant obstruction to prograde blood flow across the tricuspid valve in the newborn period. To address the disturbance to prograde pulmonary blood flow, the patient underwent successful ductal stent placement in the neonatal period. A troponin elevation was noted shortly after birth, but no evidence of coronary compression or involvement was demonstrated by coronary angiography. The patient has subsequently been treated with sirolimus over a period of three months, with noted regression in tumors and improvement in tricuspid valve inflow. CONCLUSIONS: A brief review of the literature regarding the diagnosis, treatment, and management of neonatal patients with cardiac rhabdomyomas is presented. A combined percutaneous and medical management approach may be of benefit in future cases of rhabdomyomas causing obstruction to pulmonary blood flow.
Formação de professores no ensino de ciências e matemática: os desvios correntes da profissão na crise estrutural do capital
Authors: Luz Greycianne Felix Cavalcante , Barroso Maria Cleide da Silva , Holanda Francisca Helena de Oliveira 
Published: April 2020

A formação dos professores é parte essencial para a efetivação do objetivo da educação, tendo em vista que o docente é o agente responsável pela transmissão de conhecimento é necessário que este tenha acesso a uma boa formação. Com uma aproximação a rede pública de ensino, mais especificamente de alunos das 1ª séries do Ensino Médio, em que se verifica a dificuldade que esses alunos trazem de conhecimentos já adquiridos em séries anteriores. Que reflete na dificuldade de aprender conteúdos mais específicos que tem como pré-requisito assuntos bases que os alunos não conseguiram ter domínio no Nível Fundamental. Pode-se observar a carência na formação docente, desta forma faz-se necessário analisar como a educação é inserida no sistema capitalista, qual o papel, a função que a educação desempenha neste sistema ao qual se vive. Para isto, apoia-se em argumentações de diversos autores que compartilham de uma base comum: a igualdade entre todos, uma sociedade sem distinção entre classes, sendo que todos sejam tratados da mesma forma, e com os mesmos direitos e deveres.
Fatores de risco e complicações da tuberculose em decorrência do abandono do tratamento
Authors: Silva Lorena Farias da , Carvalho Nayara Silva de , Souza Bárbara Willyane Lopes de , Castro Raniely da Costa , Feitosa Ana Paula Andrade Ramos , Martins Victor Hugo da Silva 
Published: April 2020

Este trabalho tem como objetivo identificar e analisar fatores de risco, complicações e perfil de indivíduos perante abandono do tratamento da tuberculose. Trata-se de uma revisão integrativa da literatura de estudos entre 2015 a 2020. Para o levantamento dos estudos foi utilizada fonte disponibilizada pela consulta à base de dados da Biblioteca Virtual em Saúde com os descritores “Tuberculose”, “Fator de Risco” e “Adesão ao Tratamento”. Autores corroboram que fatores de risco como consumo de drogas licitas e ilícitas, melhora clínica durante o tratamento, efeitos adversos dos medicamentos e descontinuidade do cuidado influenciam na falta de adesão ao tratamento, bem como o perfil de homens, adultos-jovens e baixa escolaridade serem os mais citados nos estudos. Observou-se a necessidade dos serviços de saúde buscarem novas estratégias para suas práticas desenvolvidas, humanização de sua assistência e fortalecimento do vínculo com o usuário.
Avaliação sensorial de iogurte caprino prebiótico adicionado de geleia da polpa de mandacaru e maracujá
Authors: Ramos Jailton de Araújo , Jerônimo Heloísa Maria Ângelo , Nóbrega Jéssica Patrícia de Medeiros , Soares Juliana Késsia Barbosa , Oliveira Maria Elieidy Gomes de , Viera Vanessa Bordin , Martins Ana Cristina Silveira 
Published: April 2020

O iogurte é considerado uma boa fonte de proteína, cálcio, riboflavina e vitamina B12, que apresenta efeitos benéficos para os seres humanos. Diante do exposto, objetivou-se, com o presente estudo, elaborar um iogurte caprino prebiótico, adicionado de geleia do maracujazeiro (Passiflora edulis), e da polpa do mandacaru (Cereus jamacaru) e avaliar os parâmetros sensoriais. Para isso, foram desenvolvidas 2 formulações de iogurtes caprinos: IC (Iogurte Caprino Controle), adicionado da cultura starter Streptococcus salivarius subsp. thermophillus e Lactobacillus delbrueckii subsp. Bulgaricus e IPREB (Iogurte Caprino Prebiótico) adicionado da fibra prebiótica oligofrutose (FOS), além da cultura starter, todos iogurtes adicionados de 15% de geleia. O processamento dos iogurtes foram realizados em triplicatas e analisados nos tempos 1, 7, 14, 21 e 28 dias de armazenamento refrigerado (4 ±1 °C). Pode-se observar, a partir dos resultados encontrados que não houve diferença estatística (p>0,05) entre as formulações, referente aos atributos aparência, cor, aroma, sabor, consistência e avaliação global. De modo geral, pode-se observar que todos os parâmetros sensoriais, as formulações foram bem aceitas, visto que as notas variaram entre os termos hedônicos “gostei moderadamente” (nota = 7) à “gostei muito” (nota = 8). Com isso, percebe-se que o desenvolvimento do iogurte caprino prebiótico adicionado de geleia de mandacaru e maracujá tem grande potencial de comercialização, agregando em um mesmo produto características funcionais e sensoriais atrativas.
A arborização melhora o conforto térmico em áreas urbanas: O caso de Juazeiro do Norte, Ceará
Authors: Barboza Eliezio Nascimento , Alencar Girlaine Souza da Silva , Alencar Francisco Hugo Hermógenes de 
Published: April 2020

Os espaços urbanos no Brasil vêm sendo alterados ao longo do tempo, as cidades se tornaram um meio artificial e provocaram amplas mudanças no clima urbano. A retirada da cobertura vegetal e as propriedades dos materiais que constituem as superfícies modificadas como o asfaltamento, aumentou o escoamento superficial, diminuiu a umidade e modificou da velocidade dos ventos, aumentando a temperatura e causando desconforto térmico. Nesse contexto, é importante que sejam dadas alternativas para mitigar os impactos gerados. O objetivo deste artigo é verificar as oscilações das variáveis climatológicas: temperatura mínima, temperatura máxima, umidade relativa do ar e velocidade dos ventos em dois Bairros da cidade de Juazeiro do Norte/CE. Para a realização da pesquisa, foram realizadas medições no Bairro Pirajá e no Parque Ecológico das Timbaúbas. Foram selecionados 12 pontos para realização das coletas. Utilizou-se o Termo-Higro-Anemômetro digital portátil marca Instrutherm, modelo THAR-185. Os dados foram coletados nos meses de: agosto, setembro, outubro, novembro e dezembro de 2019, por ser o período mais quente do ano. Os resultados evidenciaram que a presença de arborização interfere nas variáveis climáticas e desempenha uma função essencial na melhoria do conforto térmico.
Perancangan Desain Sistem Informasi Geografis Pemetaan Desa Mandiri Energi Kec. Pangalengan Kab. Bandung
Authors: Targa Sapanji R. A. E. Virgana , Hamdani Dani 
Published: April 2020

Kecamatan Pangalengan mempunyai keunikan dan kekhasan, seperti faktor ketinggian, kelompok pertanian, kelompok perternakan, perkebunan rakyat maupun perkebunan besar/negara. Peternakan sapi yang dimiliki secara individu tersebar di semua desa kecuali desa Lamajang,setiap peternak hampir memiliki reaktor biogas tetapi pengelolaan tidak maksimal sehingga hasil biogas tidak terlalu signifikan terhadap rumah tangga. Perkebunan rakyat yang tersebar hampir disetiap desa, ada potensi energi biomassa, sampah serpihan atau hasil kayu yang dibuang, belum dapat dimanfaatkan secara maksimal. Danau atau situ besar di Kecamatan Pangalengan, seperti situ Cileunca yang aliran airnya digunakan oleh sekitar 3 perusahaan listrik negara (Indonesia Power) sampai di daerah Cikalong, hasil energi yang dihasilkan cukup besar dengan daftar sebagai berikut : Sub Unit PLTA Plengan 6,87 MW, Sub Unit PLTA Lamajan 19,56 MW, Sub Unit PLTA Cikalong 19,20 MW. Juga ada PLTU yang dihasilkan oleh Gunung Windu atau Wayang di Desa Banjarsari. Perkebunan besar/negara yang beroperasi di Kecamatan Pangalengan ratusan hektar, tetapi apakah hasil biomassa perkebunannya sudah di optimalkan untuk kepentingan energi. Dapat disimpulkan bahwa Kecamatan Pangalengan mempunyai potensi desa mandiri energi, hasil alam yang melimpah tanah, air, dan udara, seharusnya pengelolaan energi di kecamatan ini harusnya lebih baik lagi, untuk sebaik-baiknya digunakan bagi kesejahteraan rakyat.
Layanan Informasi Penerimaan Mahasiswa Baru Melalui Aplikasi Email Autoresponder
Authors: Rubedo Hendar , Suwandi Herwan , Mauluddin Syahrul 
Published: April 2020

Penelitian ini bertujuan untuk membuat media alternatif berupa layanan informasi penerimaan mahasiswa baru (PMB) yang bersifat otomatis di Universitas Wanita Internasional. Hal ini karena panitia PMB memerlukan waktu yang lama untuk mengirimkan satu persatu pengumuman hasil ujian saringan masuk (USM) melalui Short Message Services (SMS). Selain itu, layanan informasi PMB seperti profil universitas, kurikulum, pembayaran PMB perlu memiliki media alternatif selain penyampaian melalui website kampus yang memungkinkan adanya gangguan. Solusi yang ditawarkan melalui penelitian ini yaitu membangun aplikasi email autoresponder yang dapat melayani permintaan informasi terkait PMB secara otomatis. Untuk mencapai itu semua, dalam penelitian ini menggunakan metode pengembangan sistem prototipe dengan pendekatan berorientasi objek. Aplikasi email autoresponder ini dibangun menggunakan java SE dan database MySQL. Dengan adanya aplikasi email autoresponder maka peserta PMB mempunyai media alternatif untuk mendapatkan informasi PMB. Aplikasi tersebut akan mengirimkan balasan secara otomatis sesuai permintaan. Berdasarkan pengujian sebanyak 10 kali, lamanya proses mendapatkan balasan adalah antara 19 detik sampai 27 detik dengan rata-rata 24,19 detik
Sharī‘a Scripts: A Historical Anthropology
Authors: Gingrich Andre 
Published: April 2020

While the Yemen seems to be stumbling from one disaster into the next, it is good to see how some of the best experts in Yemeni studies continue their work in ways that will be useful in the country’s future. The present volume is not only bound to become recognized soon as the magnum opus by Brinkley Messick, professor of anthropology and Middle Eastern, South Asian and African studies at Columbia University and one of the world’s leading experts in Yemeni studies today. More importantly still, Sharī‘a Scripts features all the qualities required for a true academic milestone in Yemen-related scholarship for decades to come, with potential ramifications for the historical and legal anthropology of the Middle East at large. This volume is based on half a lifetime of analytical and comparative studies that began during the author’s first fieldwork period in the central and southern highlands of northern Yemen during the 1970s. Messick meticulously examines the structures of jurisprudence (the “library” in his terms) with the methodologies and techniques of textual scholarship, while relating it to the “archive” of records concerning everyday interactions in legal life as embedded within the practical interplay of fields between orality and scriptural statements.
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Islam without Europe: Traditions of Reform in Eighteenth-Century Islamic Thought
Authors: Lawrence Bruce B. 
Published: April 2020

It is hard to exaggerate the scope or scale of this major monograph from one of the foremost Arab Muslim scholars of his generation, Ahmad Dallal, formerly Provost at the American University of Beirut, and now Dean of Georgetown University Qatar.In carefully orchestrated arguments, with massive documentary evidence, Dallal addresses eighteenth century theological/juridical issues across the span of the Muslim world. He touches on intellectual giants and reform movements from Senegal to Syria, from Yemen to India, delving deeply into complex debates that continue to resonate. Islam without Europe catapults Dallal into the company of revisionists who are also global historians, those looking for a way to redefine Islam outside the parameters of European historical conventions.
To download full review, click on PDF.
Images of the Prophet Muhammad in English Literature
Authors: Parray Tauseef Ahmed 
Published: April 2020

‘Literary Orientalism’, a significant and fast-emerging sub-genre, is simply defined as “the study of the (mis)representation of Islam and Muslims in the English (literary) works.” In this field, one of the prominent Muslim writers from India is Abdur Raheem Kidwai (Professor of English, and Director, K.A. Nizami Centre for Quranic Studies, Aligarh Muslim University, India). Some of his previous works in this genre include Orientalism in Lord Byron’s Turkish Tales (1995); The Crescent and the Cross (1997); Stranger than Fiction (2000); Literary Orientalism (2009); Believing and Belonging (2016); and Orientalism in English Literature (2016).
To download full review, click on PDF.
Mediating Islam and Modernity: Sir Syed, Iqbal, and Azad
Authors: Dar Owais Manzoor 
Published: April 2020

The question of Islam’s compatibility with modernity (and other interrelated aspects like democracy, rationality, nationalism, etc.) has been debated for more than two centuries. In the Subcontinent, this debate started with British imperialism (the so-called British Raj, 1857-1947). Scholars like Chirag Ali (d. 1895), Sir Syed Ahmad Khan (d. 1898), Allama Iqbal (d. 1938), Abul Kalam Azad (d. 1958), Shibli Numani (d. 1914), Mumtaz Ali (d. 1974), Syed Mawdudi (d. 1979), Amin Ihsan Islahi (d. 1997), and Abul Hassan Ali Nadwi (d. 1999) offered various critical responses. The debate still manifests in different forms, whether regarding nationalism or secularism, rationality or progressive politics. A plethora of mostly apologetic literature has been produced on the question. A recent addition to this literature is Parray’s Mediating Islam and Modernity.
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Rationale for a strategic framework to create a competitive space in the domestic consumer market
Authors: Chorna Marina , Buhrimenko Roman , Zonwire Austin 
Published: April 2020

Introduction. Increased competition in the domestic consumer market requires retailers to find new methods of competition on the base of new market spacescreation. Purpose. Formation of strategic bases for creation of retail enterprises by new non-competitive market space. Methods. Analysis and synthesis, SPACE analysis, graphic construction, scientific abstraction. Results. The author’s vision of the strategic thinking concept as a basis for strategic transformation of an enterprise to new market space, which forms on the base of the needs of strategic self-identification, awareness of strategic risk and strategic protection, is presented. The role of strategic intuition and its essence in decision making is clarified. The comprehensive approach is proposed for determining the degree of market environment compaction and, accordingly, of competition (market lever), in which the existence of an enterprise under traditional competition laws is unlikely. On the base of comparative analysis, the feasibility of applying the principles of the SPACE coordinate system for constructingthe market lever in the following areas: market saturation, influencebranching, intellectual capacity, innovativeness is substantiated. Each direction is interpreted in meaningful criteria which are determined by the relevant indices. All indices of the market lever system are unified and standardized in their architecture, which allows their generalizing into single system and forming integral values in each of the four directions. Discussion. Interpreting the results of the market leverposition assessment, determining the necessary and sufficient boundaries of the market space (the formation of the blue and red oceans), are worth doing as they will determine the enterprise’sstrategic alternatives.