bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autologous cell-free serum preparations in the management of knee osteoarthritis: what is the current clinical evidence?
Authors: Angadi Darshan S. , Macdonald Hamish , Atwal Navraj 
Published: March 2020

Abstract
Background
There is paucity in the current literature regarding clinical outcomes of autologous cell-free serum preparations. The objective of this paper is to collate the clinical evidence and review the results of intraarticular injections of autologous cell-free serum preparations in the management of knee osteoarthritis (OA).

Methods
A comprehensive English literature search was undertaken using the healthcare database website (https://hdas.nice.org.uk/). The PubMed, Medline, CINAHL, Embase and the Cochrane library databases were searched to identify all studies of autologous protein solution/autologous conditioned serum (ACS/APS) in the management of knee OA. We evaluated the reported clinical outcomes with respect to pain, function, morbidity, adverse effects and complications.

Results
Fifteen relevant articles were identified in the current literature. Outcomes following injection of ACS/APS have been reported in patients with age range (34–87 years) and unilateral or bilateral knee OA. Seven studies reported improvement in visual analog scale (VAS) whereas the Western Ontario and McMaster Universities osteoarthritis instrument (WOMAC) score improved in nine studies. Considerable variation was noted in the injection technique and duration of post-procedure assessment with only one study reporting long-term follow-up beyond 24 months. Joint swelling and injection-site pain were reported to be the most common complications; only one study reported a case of septic arthritis. However, no evidence is available to clearly identify factors that may predict the outcomes following this procedure.

Conclusion
Current data from the clinical studies would suggest that the intraarticular administration of autologous cell-free serum preparations, such as ACS/APS, in patients with knee OA may improve pain and function, with limited morbidity. High-quality clinical trials with stratified patient cohorts, longer follow-up duration and robust reporting of outcome measures are essential to improve the understanding of the indications and clinical effectiveness of these novel products.
Acute appendicitis within incisional hernia sac: a unique case report
Authors: Issa Mohamed G. 
Published: March 2020

Abstract
Background
Incisional hernia appendicitis is a rare form in which the vermiform appendix is located within the hernial sac. It is seen in less than 1% of inguinal hernia. Most often, the cases are misdiagnosed as incarcerated or strangulated hernia.

Case presentation
A 59-year-old female with history of hysterectomy 10 days ago for fibroid, came to the emergency department with diffuse abdominal pain and severe vomiting and absolute constipation for 3 days. Abdominal U/S was done and revealed inflamed fat within the hernia sac along with minimal collection. A defect was seen at the anterior abdominal wall measuring about 2.4 cm passing bowel loops and collection. CT scan with IV contrast revealed an inflamed appendix passing through the incisional hernia.

Conclusions
Appendicitis within a hernia sac is unusual with the incidence being 0.13% of all acute appendicitis. Acute hernia appendicitis is almost never been diagnosed prior to surgery. Most often, the diagnosis is incarcerated or strangulated hernia. The differential diagnosis should include hernia sac appendicitis for patients with signs of inflammatory process ongoing at the hernia sac.
Deterioration mechanism of steam-cured concrete subjected to coupled environmental acid and drying action
Authors: Long Guangcheng , Xie Youjun , Luo Zhiyu , Qu Lu , Zhou John L. , Li Wengui 
Published: March 2020

AbstractIn order to investigate the deterioration mechanism of steam-cured concrete under severe environmental actions such as acid rain corrosion, salt corrosion, and cyclic thermal loading, accelerated corrosion tests were conducted in this study. Surface damage as well as deteriorative kinetics of steam-cured concrete and cement paste suffering from coupled acid-thermal actions was investigated by soaking-drying cycle experiments. The effects of mineral admixture, curing regime and corrosion condition on the durability were all comparatively studied, and the X-ray diffractograms and nanoindentation were applied to analyse the mechanism of corrosion deterioration. The results revealed that compared with the cementitious materials under standard curing, larger depth and faster corrosion were observed for steam-cured concrete and cement paste, which might be partly attributed to the lower content of hydrated production presented in steam-cured specimens. Besides, under acid solution soaking-drying cycle regime, there was significant higher corrosion depth compared to only soaking in acid solution. The corrosion depth under steam curing and soaking-drying condition increased by 156.68% and 44.17%, respectively, compared with those under standard curing and only soaking treatment. In addition, fly ash effectively decreased the corrosion depth of steam-cured cement paste and concrete by 64.98% and 16.33%, respectively.
Keeping the brain in mind: why neuroscience matters to 21st-century psychiatrists
Authors: Tracy Derek K. 
Published: March 2020

SUMMARYPsychiatry intertwines mind and brain, sometimes in a strained marriage. Psychiatrists feel the criticism of a ‘narrow’ biological or medical (and medication) focus, and we are very aware of the limitations of all treatments and diagnostic systems. Many understandably move towards a more social approach, seeing individuals in their wider lives. But there are dangers in losing the brain, something unique to our specialty in the world of mental health. This reflective piece calls for us to rediscover the joy of the science of the brain, which augments, not conflicts with, psychosocial approaches.
The link between formal thought disorder and social functioning in schizophrenia: A meta-analysis
Authors: Marggraf Matthew P. , Lysaker Paul H. , Salyers Michelle P. , Minor Kyle S. 
Published: March 2020

Abstract

Background.
Formal thought disorder (FTD) and social functioning impairments are core symptoms of schizophrenia. Although both have been observed for over a century, the strength of the relationship between FTD and social functioning remains unclear. Furthermore, a variety of methodological approaches have been used to assess these constructs—which may contribute to inconsistency in reported associations. This meta-analysis aimed to: (a) systematically test the relationship between FTD and social functioning and (b) determine if the methodology used to assess FTD and/or social functioning moderates this relationship.

Methods.
Following Preferred Reporting Items for Systematic reviews and Meta-analyses (PRISMA) guidelines, a targeted literature search was conducted on studies examining the relationship between FTD and social functioning. Correlations were extracted and used to calculate weighted mean effect sizes using a random effects model.

Results.
A total of 1,478 participants across 13 unique studies were included in this meta-analysis. A small-medium inverse association (r = −0.23, p < 0.001) was observed between FTD and social functioning. Although heterogeneity analyses produced a significant Q-statistic (Q = 52.77, p = <0.001), the relationship between FTD and social functioning was not moderated by methodology, study quality, demographic variables, or clinical factors.

Conclusions.
Findings illustrate a negative association between FTD and social functioning. Despite differences in the methodological approach used and type of information assessed, measurement type and clinical factors did not moderate the relationship between FTD and social functioning. Future studies should explore whether other variables, such as cognitive processes (e.g., social cognition), may account for variability in associations between these constructs.
β1 integrin-mediated signaling regulates MT1-MMP phosphorylation to promote tumor cell invasion
Authors: Grafinger Olivia R. , Gorshtein Genya , Stirling Tyler , Brasher Megan I. , Coppolino Marc G. 
Published: March 2020

ABSTRACT
Malignant cancer cells can invade extracellular matrix (ECM) through the formation of F-actin-rich subcellular structures termed invadopodia. ECM degradation at invadopodia is mediated by matrix metalloproteinases (MMPs), and recent findings indicate that membrane-anchored membrane type 1-matrix metalloproteinase (MT1-MMP, also known as MMP14) has a primary role in this process. Maintenance of an invasive phenotype is dependent on internalization of MT1-MMP from the plasma membrane and its recycling to sites of ECM remodeling. Internalization of MT1-MMP is dependent on its phosphorylation, and here we examine the role of β1 integrin-mediated signaling in this process. Activation of β1 integrin using the antibody P4G11 induced phosphorylation and internalization of MT1-MMP and resulted in increased cellular invasiveness and invadopodium formation in vitro. We also observed phosphorylation of Src and epidermal growth factor receptor (EGFR) and an increase in their association in response to β1 integrin activation, and determined that Src and EGFR promote phosphorylation of MT1-MMP on Thr567. These results suggest that MT1-MMP phosphorylation is regulated by a β1 integrin-Src-EGFR signaling pathway that promotes recycling of MT1-MMP to sites of invadopodia formation during cancer cell invasion.
This article has an associated First Person interview with the first author of the paper.
The role of stationary intraoral tomosynthesis in reducing proximal overlap in bitewing radiography
Authors: Mauriello Sally M , Broome Angela M , Platin Enrique , Mol André , Inscoe Christina , Lu Jianping , Zhou Otto , Moss Kevin 
Published: March 2020

Objectives: This study examined the utility of stationary intraoral tomosynthesis (s-IOT) in opening proximal contacts in bitewing radiography. Methods: 11 DENTSPLY Rinn Dental X-ray Teaching and Training Replica mannequins (Model #546002, Elgin, Ill) were imaged with a prototype s-IOT device (Surround Medical Systems, Morrisville, NC) and standard bitewing (SBW) technique. Premolar and molar bitewings were acquired with each system. Image receptor holders were used to position receptors and aid in the alignment of the position indicating devices. An expert operator (having more than 5 years of experience in intraoral radiography) acquired the images with the s-IOT prototype and standard intraoral X-ray devices. Images were assessed to analyze percentage overlap of the proximal surfaces using the tools available in ImageJ (NIH, Bethesda Maryland). Results: 253-paired surfaces were included in the analysis. The difference in overlap was statistically significant with standard bitewing (SBW) images resulting in a median overlap of 13%, a minimum of 0%, a maximum of 100% and an interquartile range of 40%. s-IOT resulted in a median overlap of 1%, a minimum of 0%, a maximum of 37% and an interquartile range of 0%. The s-IOT prototype substantially reduced proximal surface overlap compared to conventional bitewing radiography. Conclusions: The use of s-IOT reduced proximal contact overlap compared to standard bitewing radiography for an experienced radiographer. Stationary intraoral tomosynthesis may be a potential alternative to SBW radiography, reducing the number of retakes due to closed contacts.
Controlled administration of cannabis to mitigate cannabis-attributable harm among recreational users: a quasi-experimental study in Germany
Authors: Manthey Jakob , Kalke Jens , Rehm Jürgen , Rosenkranz Moritz , Verthein Uwe 
Published: March 2020

Background:New approaches are required to slow down or reverse increasing trends of levels of delta-9-tetrahydrocannabinol (THC) and cannabis-attributable hospitalizations in Germany. Legal access to cannabis may constitute one viable effective policy response; however, available evidence does not suffice to inform a regulation model for Germany. The proposed study aims to reduce harm for cannabis users through legal access to herbal cannabis through pharmacies.Protocol:A quasi-experimental study comparing cannabis users with legal access to herbal cannabis (Berlin, intervention group) to those without legal access (Hamburg, control group) (total N=698). As the primary outcome, we hypothesize that: 1) illegal THC consumption will reduce by at least 50% in the intervention group and 2) total THC exposure in the intervention group will be reduced by at least 10% lower than that of the control group, taking into account baseline values. Secondary outcomes comprise measures of frequency of use, THC-impaired driving, and mode of administration. Paired t-tests and multilevel regression models will be performed for statistical analyses.Discussion:This study proposal is currently being reviewed by the ‘Federal Institute for Drugs and Medical Devices’ – the body responsible for approving research studies on classified substances, including cannabis. Upon approval and prior to the start of the study, a full ethical review will be undertaken. Results may inform a regulation model for Germany and other jurisdictions and are expected to deepen the understanding of the effects of legal access to cannabis.Pre-registration:German Clinical Trials Register (DRKS), DRKS00020829
Accuracy of short tandem repeats genotyping tools in whole exome sequencing data
Authors: Halman Andreas , Oshlack Alicia 
Published: March 2020

Background: Short tandem repeats are an important source of genetic variation. They are highly mutable and repeat expansions are associated dozens of human disorders, such as Huntington's disease and spinocerebellar ataxias. Technical advantages in sequencing technology have made it possible to analyse these repeats at large scale; however, accurate genotyping is still a challenging task. We compared four different short tandem repeats genotyping tools on whole exome sequencing data to determine their genotyping performance and limits, which will aid other researchers in choosing a suitable tool and parameters for analysis. Methods: The analysis was performed on the Simons Simplex Collection dataset, where we used a novel method of evaluation with accuracy determined by the rate of homozygous calls on the X chromosome of male samples. In total we analysed 433 samples and around a million genotypes for evaluating tools on whole exome sequencing data. Results: We determined a relatively good performance of all tools when genotyping repeats of 3-6 bp in length, which could be improved with coverage and quality score filtering. However, genotyping homopolymers was challenging for all tools and a high error rate was present across different thresholds of coverage and quality scores. Interestingly, dinucleotide repeats displayed a high error rate as well, which was found to be mainly caused by the AC/TG repeats. Overall, LobSTR was able to make the most calls and was also the fastest tool, while RepeatSeq and HipSTR exhibited the lowest heterozygous error rate at low coverage. Conclusions: All tools have different strengths and weaknesses and the choice may depend on the application. In this analysis we demonstrated the effect of using different filtering parameters and offered recommendations based on the trade-off between the best accuracy of genotyping and the highest number of calls.
Determinan Keputusan Pekerja Mandiri menjadi Peserta Jaminan Kesehatan Nasional
Authors: Laila Jumatra , Ainy Asmaripa , Safriantini Dian 
Published: March 2020

Background: National health insurance is mandatory for all Indonesians. In Ogan Ilir Regency, the lowest percentage (24,14%) of its participants in December 2016 was found in Indralaya Utara Sub-district, and self-employed participants in this sub-district were only 6,99%. This study aimed to analyze the determinants of the self-employed’s decision to become national health insurance participants in Indralaya Utara Sub-district. Method: This was a cross-sectional study. The population was self-employed in Indralaya Utara Sub-district. The sample was 108 respondents who were selected using cluster sampling and consecutive sampling techniques. Data analysis was conducted by univariate and bivariate with chi-square statistical test. Results: The results illustrated that 18,52% of respondents decided to become national health insurance participants. Variables with p-value<0,005 were: knowledge about national health insurance (p-value=0,011), trust (p-value=0.000), perception about national health insurance (p-value=0,000), attitude (p-value=0,000), income (p-value=0,002), family support (p-value=0,005). Variables with p-value≥0,005 were: education (p-value=0,234), perception about health facilities (p-value=0,162), distance to health facilities (p-value=0,355), health workers support (p-value=0,112). Conclusion: In conclusion, percentage of self-employed who decided become national health insurance participants was still small. Associated factors to the decision of self-employed as participants were: knowledge about national health insurance, trust, perception about national health insurance, attitude, income and family support. It is suggested that the Social Security Administrative Body for Health should routinely conduct socialization on national health insurance to improve the percentage of its participation for self-employed and the benefits of national health insurance could be felt by the entire community.
Surgical treatment of symptomatic post-slipped capital femoral epiphysis deformity: A comparative study between hip arthroscopy and surgical hip dislocation with or without intertrochanteric osteotomy
Authors: Wylie James D. , McClincy Michael P. , Uppal Nishant , Miller Patricia E. , Kim Young-Jo , Millis Michael B. , Yen Yi-Meng , Novais Eduardo N. 
Published: March 2020

Purpose Our primary research question was to investigate the severity of deformity and articular damage as well as outcomes in patients undergoing hip arthroscopy compared with open surgery for the treatment of symptomatic slipped capital femoral epiphysis (SCFE) deformity. Methods Retrospective review of surgical treatment of symptomatic SCFE deformity with a minimum one-year follow-up. Patients were divided into three groups: the arthroscopic group, surgical hip dislocation(SHD) group and SHD with femoral osteotomy (SHD+ITO) group. Deformity severity was quantified. Hip outcome was assessed by the modified Merle d'Aubigné Postel (MDP) scores. Results There were more severe slips treated by SHD and SHD+ITO. There was more severe deformity in the SHD+ITO group than the arthroscopy group (p < 0.001). There were more full thickness acetabular cartilage defects in the SHD and the SHD+ITO groups (> 40%) compared with the arthroscopy group (11%; p = 0.03). The SHD+ITO and SHD group had lower MDP scores compared with the arthroscopy group both before and after surgery but no difference was detected in the amount of improvement from surgery across groups (p > 0.05). Moderate and severe SCFEs had worse preoperative scores but improvement was not different compared with mild SCFEs (p > 0.05). Conclusion Patients undergoing open treatment had more severe SCFE deformity with more extensive articular damage at reconstructive surgery compared with patients undergoing arthroscopy. All groups with SCFE deformity had improved pain and hip function postoperatively. Level of Evidence III
Single preloaded piezoelectric-ceramic-stack-actuator-based fast steering mirror with an ultrahigh natural frequency
Authors: Zhou Ziye , Feng Zhongyi , Xian Hao , Huang Linhai 
Published: March 2020

To meet the requirements of the adaptive optics systems with high bandwidths and large excursion angles, we propose a fast steering mirror (FSM) with an ultrahigh natural frequency and a large angular range. The proposed FSM is driven by a preloaded piezoelectric ceramic stack actuator (PCSA), which has a higher shear stress limit in the working direction. We describe the structure of the preloading device and analyze the stiffness improvement of the preloaded PCSA. Then we introduce the structure of the proposed FSM and perform theoretical analysis based on the established static model and dynamical model. We also build an experimental setup of the proposed FSM. The experimental results show that the angular range of the proposed FSM is up to 8.4 mrad, and its first natural frequency is 6660 Hz, which surpass the performances of current FSMs.
Multispectral image fusion based pedestrian detection using a multilayer fused deconvolutional single-shot detector
Authors: Chen Yunfan , Shin Hyunchul 
Published: March 2020

Recent research has demonstrated that effective fusion of multispectral images (visible and thermal images) enables robust pedestrian detection under various illumination conditions (e.g., daytime and nighttime). However, there are some open problems such as poor performance in small-sized pedestrian detection and high computational cost of multispectral information fusion. This paper proposes a multilayer fused deconvolutional single-shot detector that contains a two-stream convolutional module (TCM) and a multilayer fused deconvolutional module (MFDM). The TCM is used to extract convolutional features from multispectral input images. Then fusion blocks are incorporated into the MFDM to combine high-level features with rich semantic information and low-level features with detailed information to generate features with strong a representational power for small pedestrian instances. In addition, we fuse multispectral information at multiple deconvolutional layers in the MFDM via fusion blocks. This multilayer fusion strategy adaptively makes the most use of visible and thermal information. In addition, using fusion blocks for multilayer fusion can reduce the extra computational cost and redundant parameters. Empirical experiments show that the proposed approach achieves an 81.82% average precision (AP) on a new small-sized multispectral pedestrian dataset. The proposed method achieves the best performance on two well-known public multispectral datasets. On the KAIST multispectral pedestrian benchmark, for example, our method achieves a 97.36% AP and a 20 fps detection speed, which outperforms the state-of-the-art published method by 6.82% in AP and is three times faster in its detection speed.
Ultracompact optical switch using a single semisymmetric Fano nanobeam cavity
Authors: Cheng Ziwei , Dong Jianji , Zhang Xinliang 
Published: March 2020

We propose and theoretically analyze a generalized four-port waveguide-cavity system with a novel, to the best of our knowledge, semisymmetric Fano structure. By applying the system to a silicon-based photonic crystal nanobeam cavity (PCNC), we experimentally demonstrate an ultracompact crossbar optical switch with high drop port transmission. A low insertion loss of 1.5 dB in the drop port at the cross state is achieved comparing to the 8.5 dB insertion loss in a traditional non-Fano structure. The device is also benefited by the high quality factor and small mode volume for efficient switching and the ultracompact footprint of

14

µ

m

2

in the core structure. The proposed PCNC switch shows great potential in various optical systems on chip to increase the integration and reduce energy consumption.