bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic accuracy of heart rate variability as a screening tool for mild neurocognitive disorder
Authors: Czopek-Rowinska Julia , de Bruin Eling D. , Manser Patrick 
Published: December 2024

BackgroundMild neurocognitive disorder (mNCD) is recognized as an early stage of dementia and is gaining attention as a significant healthcare problem due to current demographic changes and increasing numbers of patients. Timely detection of mNCD provides an opportunity for early interventions that can potentially slow down or prevent cognitive decline. Heart rate variability (HRV) may be a promising measure, as it has been shown to be sensitive to cognitive impairment. However, there is currently no evidence regarding the diagnostic accuracy of HRV measurements in the context of the mNCD population. This study aimed to evaluate the diagnostic accuracy of vagally-mediated HRV (vm-HRV) as a screening tool for mNCD and to investigate the relationship between vm-HRV with executive functioning and depression in older adults who have mNCD.MethodsWe retrospectively analyzed data from healthy older adults (HOA) and individuals with a clinical diagnosis of mNCD with a biomarker-supported characterization of the etiology of mNCD. Diagnostic accuracy was evaluated using receiver operating characteristic curve analysis based on the area under the curve. Sensitivity and specificity were calculated based on the optimal threshold provided by Youden’s Index. Multiple linear regression analyses were conducted to investigate the relationship between vm-HRV and executive functioning and depression.ResultsThis analysis included 42 HOA and 29 individuals with mNCD. The relative power of high frequency was found to be increased in individuals with mNCD. The greatest AUC calculated was 0.68 (with 95% CI: 0.56, 0.81) for the relative power of high frequency. AUCs for other vm-HRV parameters were between 0.53 and 0.61. No consistent correlations were found between vm-HRV and executive functioning or depression.ConclusionIt appears that vm-HRV parameters alone are insufficient to reliably distinguish between HOA and older adults with mNCD. Additionally, the relationship between vm-HRV and executive functioning remains unclear and requires further investigation. Prospective studies that encompass a broad range of neurocognitive disorders, HRV measurements, neuroimaging, and multimodal approaches that consider a variety of functional domains affected in mNCD are warranted to further investigate the potential of vm-HRV as part of a multimodal screening tool for mNCD. These multimodal measures have the potential to improve the early detection of mNCD in the future.
Association between tinnitus and hearing impairment among older adults with age-related hearing loss: a multi-center cross-sectional study
Authors: Chen Zhifeng , Lu Yan , Chen Chenyu , Lin Shaolian , Xie Ting , Luo Xiaoyang , Lin Yanchun , Chen Yuqing , Feng Yong , Xiong Guanxia , Ma Xiulan , Zeng Chaojun , Lin Chang 
Published: December 2024

ObjectiveThe relationship between tinnitus in the elderly with hearing loss remains elusive. This study aimed to reveal the association between tinnitus and hearing impairment among older adults with age-related hearing loss (ARHL).MethodsThis cross-sectional study was conducted among a population of outpatients diagnosed with ARHL at four medical centers in different regions of China, from June 2020 to June 2023. ARHL patients were divided into two groups based on their self-reported tinnitus: tinnitus and non-tinnitus. Multivariable linear regression models were used to assess the association between tinnitus and hearing impairment in ARHL patients. Subgroup analyses, stratified by gender and age, were performed to further evaluate the association.ResultsA total of 418 older adults with ARHL were included in the study. Compared to the non-tinnitus group, ARHL patients with tinnitus had lower hearing thresholds (β = −5.07; 95% confidence interval (CI) −9.32 to −0.81; p = 0.020). On subgroup analyses stratified by gender and age, the male ARHL patients with tinnitus still had lower hearing thresholds compared to those without tinnitus (β = −6.96; 95% CI −12.70 to 1.22; p = 0.018). In females, tinnitus was not associated with hearing thresholds (β = −3.69; 95% CI −10.11 to 2.74, p = 0.262). There was no association between tinnitus and hearing thresholds in both the age group of ≥70 years (β = −4.31; 95% CI −9.65 to 1.03; p = 0.116) and the age group of &lt;70 years (β = −3.54; 95% CI −9.96 to 2.89; p = 0.282).ConclusionBased on this multi-center cross-sectional study, we reveal that there is no evidence for the assumption that tinnitus may exacerbate hearing loss in the elderly for the first time. On the contrary, tinnitus is associated with better hearing in the male elderly with ARHL. More extensive longitudinal studies are needed to give a comprehensive insight of the present findings and the underlying mechanisms.
A good response to furmonertinib fourth-line treatment of an advanced lung adenocarcinoma patient with EGFR exon20in and PIK3CA mutation: a case report and literature review
Authors: Sun Kai , Wang Peng 
Published: December 2024

BackgroundLung cancer, including small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), is the most prevalent cancer globally and remains the leading cause of cancer-related mortality. Epidermal growth factor receptor (EGFR) mutations, frequently observed in female NSCLC patients, have revolutionized treatment strategies with the advent of tyrosine kinase inhibitors (TKIs). These therapies significantly improve survival and are considered the standard of care for patients harboring EGFR mutations. However, most patients eventually develop resistance to EGFR-TKIs, leading to disease progression. Resistance mechanisms are classified as either EGFR-dependent or EGFR-independent, the latter involving bypass pathway activation, including dysregulation of downstream signaling cascades. EGFR-independent resistance often renders all EGFR-TKIs ineffective, necessitating further investigation into resistance mechanisms.Case summaryWe report the case of a 63-year-old Chinese woman diagnosed with synchronous lung adenocarcinoma harboring an EGFR exon 21 far-loop insertion mutation and clear cell renal cell carcinoma (ccRCC). A multidisciplinary team recommended systemic therapy for the lung adenocarcinoma and clinical observation for ccRCC. First-line treatment with bevacizumab plus pemetrexed-carboplatin achieved a progression-free survival (PFS) of 7 months. Second-line treatment with sintilimab and nedaplatin resulted in a PFS of 4.9 months. Third-line therapy with sintilimab and anlotinib proved ineffective. In the fourth line, the patient received furmonertinib, a third-generation EGFR-TKI, based on the FAVOUR trial. This treatment achieved durable disease control with excellent tolerability, yielding a PFS of 27 months and ongoing clinical benefit.ConclusionThis case demonstrates that furmonertinib can provide significant clinical benefit to NSCLC patients with complex resistance mechanisms, including those involving the PIK3CA/mTOR pathway. These findings support its potential to overcome EGFR-TKI resistance and warrant further investigation in similar clinical contexts.
Reduce the application of phosphorus fertilizer in peanut fields and improve its efficiency by using iron modified biochar to adsorb phosphorus recovery products
Authors: Zhang Junxiao , Bu Xiangxi , Huang Zhenyu , Wu Changxue , Xie Xiangwen 
Published: December 2024

IntroductionTo address the scarcity of agricultural phosphorus (P) fertilizers and reduce phosphorus accumulation in wastewater, this study employed iron-modified biochar (Fe-B) to adsorb phosphorus from water. The phosphorus-loaded iron-modified biochar (Fe-BP) was subsequently applied to peanut fields. Batch experiments were conducted to determine the optimal adsorption parameters and mechanism of Fe-B for phosphate ions (PO43−).MethodsThe field experiment utilized a randomized complete block design, comprising the following treatments: no biochar and no P fertilizer (B0P0), no biochar with conventional phosphate fertilizer (B0P1, CK, P2O5 at 144 kg ha−1), biochar with CK (B1P1), Fe-B with CK (FeB-P1), phosphorus-loaded Fe-B with CK (FeBP-P1), and phosphorus-loaded Fe-B with two-thirds CK (FeBP-P2, P2O5 at 96 kg ha-1).ResultsThe results demonstrated that the biochar dosage of 0.05 g (2 g L-1) results in a phosphate removal rate exceeding 80%. Optimal adsorption efficiency occurs within a pH range of 6-9, with a sharp decline observed at pH values above 10. The presence of NO3-, Cl-, and SO42- does not significantly affect the phosphate adsorption capacity of Fe-B, unlike HCO3- and CO32-, which reduce it. After the fifth desorption and recycling process, the adsorption capacity of the biochar decreased to 24%. The peanut yield in the FeB-P1 treatment was 50.8% higher than that in the FeBP-P2 treatment. While the phosphorus recovery efficiency (REP) does not significantly differ between FeBP-P2 and B1P1 treatments, both are superior to B0P1. Moreover, FeBP-P2 facilitated the available phosphorus concentration in the root zone.DiscussionOverall, phosphorus-loaded iron-modified biochar reduced the required amount of phosphorus fertilizer, maintain peanut yield, and enhanced phosphorus fertilizer utilization efficiency.
Psychometric validation of the Cardiac Distress Inventory - Short Form among people with cardiac diseases in Hong Kong
Authors: Fong Ted C. T. , Leung Ian C. H. , Wong Chun Ka , Jackson Alun C. , Ho Rainbow Tin Hung 
Published: December 2024

ObjectivesCardiac patients experience various somatic and psychosocial symptoms and stress is an important prognostic factor of cardiac rehabilitation. This study evaluated the psychometric properties of the 12-item Cardiac Distress Inventory – Short Form (CDI-SF) in the Chinese context.MethodsA total of 227 patients with cardiac diseases were recruited in a specialist outpatient clinic in Hong Kong between Aug 2022 and July 2023. The participants completed the CDI-SF and validated measures on psychosocial functioning and quality of life. Exploratory factor analysis and partial correlation analysis were conducted to examine the factorial validity, reliability, and convergent validity of the CDI-SF with reference to validating measures.ResultsThe 1-factor model showed adequate model fit with excellent composite reliability (ω = .92) and substantial factor loadings (λ = .64 –.94, p &lt;.01). The CDI-SF factor was negatively associated with age (r = –.21, p &lt;.01) and showed positive and strong partial correlations (r = .59 –.69, p &lt;.01) with impact of event, depression, and burnout, and negative partial correlations (r = -.43 to -.54, p &lt;.01) with resilience and quality of life.ConclusionOur study provides the first results on the psychometric properties of the CDI-SF among cardiac patients in Hong Kong. The psychometric results support the CDI-SF as a precise, valid, and reliable measure of cardiac distress in the Chinese context.
Additions to Dictyosporiaceae: Neoxylochrysis typhicola comb. et gen. nov., Two New Species and Four New Host Records from Medicinal Plants in Southwestern China
Authors: Wu Na , Du Hong-Zhi , Chethana Kandawatte Wedaralalage Thilini , Khongphinitbunjong Kitiphong , Maharachchikumbura Sajeewa S. N. , Hyde Kevin D. , Liu Jian-Kui 
Published: December 2024

Medicinal plants serve as vital resources for preventing and treating diseases, with their flowers, fruits, leaves, roots, or entire plants being utilized in the pharmaceutical industry or as direct therapeutic agents. During our investigation of microfungi associated with medicinal plants in Guizhou and Sichuan Provinces, China, several asexual and sexual fungal morphs were collected. Multi-locus phylogenetic analysis based on combined ITS, LSU, SSU and TEF1-α datasets revealed that these taxa are related to the family Dictyosporiaceae. Morphological characteristics, along with multi-locus phylogenetic analysis, supported the establishment of Dictyocheirospora alangii sp. nov. and Pseudocoleophoma rosae sp. nov., as well as the introduction of a novel genus Neoxylochrysis, which accommodates Neoxylochrysis typhicola comb. nov. (≡Pseudocoleophoma typhicola). In addition, four new host records are introduced for Aquadictyospora lignicola from Periploca forrestii, Dendryphiella eucalyptorum from Leonurus japonicus, Ophiopogon japonicus and Sambucus javanica, D. vinosa from Phytolacca americana, and Dictyocheirospora rotunda from Euonymus japonicus and Prinsepia utilis. Detailed descriptions, micrographs of the new taxa and a phylogenetic tree are provided.
The Study on the Propagation of a Driving Laser Through Gas Target Using a Neural Network: Interaction of Intense Laser with Atoms
Authors: Wang Xinyu , Qiu Yuanyuan , Qiao Yue , Guo Fuming , Wang Jun , Chen Gao , Chen Jigen , Yang Yujun 
Published: December 2024

High-order harmonic generation is one of the ways to generate attosecond ultra-short pulses. In order to accurately simulate the high-order harmonic emission, it is necessary to perform fast and accurate calculations on the interaction between the atoms and strong laser fields. The accurate profile of the laser field is obtained from the propagation through the gas target. Under the conditions of longer wavelength driving lasers and higher gas densities, the calculation of the laser field becomes more challenging. In this paper, we utilize the driving laser electric field information obtained from numerically solving the three-dimensional Maxwell’s equations as data for machine learning, enabling the prediction of the propagation process of intense laser fields using an artificial neural network. It is found that the simulation based on frequency domain can improve the accuracy of electric field by two orders of magnitude compared with the simulation directly from time domain. On this basis, the feasibility of the transfer learning scheme for laser field prediction is further studied. This study lays a foundation for the rapid and accurate simulation of the interaction between intense laser and matter by using an artificial neural network scheme.
Estimates of Some Coefficient Functionals for Close-to-Convex Functions
Authors: Trojnar-Spelina Lucyna 
Published: December 2024

For a given starlike function Fα=z1−αz2, α∈[−1,1], the class C0(Fα) is defined as follows: an analytic normalized function f belongs to C0(Fα) if it satisfies Rezf′(z)Fα(z)>0 in the open unit disk ∆. The condition defining this class can be rewritten in the following equivalent form Re{(1−αz2)f′(z)}>0, z∈∆. The family C0(Fα) is a subclass of the class of close-to-convex functions. The main aim of this paper is to maximize the modulus of a functional which is a linear combination with coefficients symmetric with respect to zero and is defined on the subfamily of C0(Fα) of functions with a fixed second coefficient in its Taylor series expansion.
Avaliação dos serviços da Atenção Primária à Saúde na Estratégia Saúde da Família em um município do Nordeste
Authors: Brito Thalanikelson de Oliveira , Farias Mariana Ramalho de , Maciel Jacques Antônio Cavalcante , Azevedo Pedro  Henrique Gomes , Ribeiro Araújo Isabelly , Mayorga Fernando  Daniel de Oliveira , Azevedo Carolina de Holanda , Teixeira Ana Karine Macedo 
Published: December 2024

A Atenção Primária à Saúde (APS) oferece serviços abrangentes que podem resolver a maioria dos problemas de saúde ao longo da vida. Diante disso, objetivou-se avaliar os atributos da Atenção Primária à Saúde na Estratégia Saúde da Família do município. Trata-se de uma pesquisa avaliativa, com delineamento transversal, realizada no período de outubro/2020 a Junho/2022 nos Centros de Saúde da Família (CSFs) da sede de Sobral/CE. A amostra consistiu em 381 usuários adultos, de ambos os gêneros, escolhidos aleatoriamente. As entrevistas foram feitas nos CSF, usando os Instrumentos de Avaliação da Atenção Primária PCATool-Brasil-2020 - Versão Adulto, que contém dados sociodemográficos e questões do tipo Likert para avaliar a APS segundo seus atributos. Os atributos da APS foram calculados pelas médias dos escores obtidos e qualitativamente nas categorias: alto e baixo, referentes à avaliação do serviço. Os resultados mostram os escores globais abaixo do valor esperado (6,6), e os fatores que mais influenciaram essa avaliação foram a falta de atendimento no período noturno e nos fins de semana, a dificuldade de comunicação externa e a condição de gestante. Assim, conclui-se que o município possui baixa orientação para os atributos gerais, essenciais e derivados, mas apresenta alta orientação em afiliação e utilização.
Therapeutically-Induced Lymphangiogenesis is Ineffective in Resolving Established Kidney Disease in Mice
Authors: Kannan Saranya , Phan Thien T. , Creed Heidi A. , Reyna Andrea J. , Baranwal Gaurav , Rich Aubrie L. , Weiss Dawson L. , Rutkowski Joseph M. 
Published: December 2024

Background:
Chronic kidney disease (CKD) counts acute kidney injuries (AKI) as one of its many underlying causes. Lymphatic vessels are important in modulating inflammation post-injury. Manipulating lymphatic vessel expansion thus has the potential to alter CKD progression. Previously, we demonstrated that renal lymphatic expansion prior to injury reduced CKD progression following an AKI. Here we test whether inducing lymphangiogenesis impacts established CKD.

Methods:
Following CKD progression, kidney lymphatics were expanded by transgenic induction of kidney-specific overexpression of vascular endothelial growth factor-D (KidVD) in aristolochic acid (AA) nephropathy and cisplatin injury aggravated with chronic high phosphate diet (CisPi) models or by infusion of kidney-targeting nanoparticles (NP) loaded with the VEGFR-3 specific ligand VEGF-C C156S in a progressive proteinuria (POD) model. Renal fibrosis and lymphatic density were determined by picrosirius red staining and immunofluorescence, respectively. Renal function was assessed by creatinine clearance rate, serum creatinine, blood urea nitrogen, urinary protein creatinine ratio and urinary albumin creatinine ratio. Renal pro-inflammatory and fibrotic markers expression were measured by qRT-PCR.

Results:
KidVD+ mice demonstrated expanded renal lymphatics while NP treatment minimally expanded lymphatics. In neither the AA nor POD model did lymphangiogenesis improve renal function or fibrosis. AA mice showed decreased Tgfb1 expression and POD mice showed increased Col4a1 expression. Expansion worsened function in CisPi CKD and increased fibrosis. CisPi kidneys also demonstrated increased expression of Mcp-1, Il1b, Col1a1, and Tgfb1 and increased macrophage numbers.

Conclusions:
Therapeutically induced lymphatic expansion is ineffective in resolving established CKD and has the potential to further worsen CKD progression.
Casos de recidiva de Hanseníase na região norte do Brasil: análise epidemiológica (2013-2022)
Authors: Rocha Vitória Pereira , Alexandre Bruno Santos 
Published: December 2024

A hanseníase é uma doença infecciosa crônica causada pela bactéria Mycobacterium leprae que afeta a pele, nervos periféricos, olhos e mucosa nasal. Possui maior prevalência em populações que vivem em condições de vulnerabilidade social, cenário de muitos municípios hiperendêmicos da Região Norte. Apesar dos esforços para reduzir a incidência, as recidivas representam um desafio significativo, indicando possíveis falhas no tratamento.
Atualidades em tratamento de artrite idiopática juvenil oligoarticular: uma revisão bibliográfica
Authors: Lucarelli Maria Clara Dornas , Sales Maria Ruth Costa , Brandão Fabíola Sampaio 
Published: December 2024

A artrite idiopática juvenil (AIJ) é uma doença inflamatória crônica com duração superior a 6 semanas, iniciada antes dos 16 anos de idade, de etiologia desconhecida. Dentre os tipos de AIJ - AIJ sistêmica, entesite associada a artrite, oligoartrite, poliartrite fator reumatoide positivo, poliartrite fator reumatoide negativo, artrite psoriásica e artrite indiferenciada - a oligoarticular é a mais comum se caracterizando por mono ou oligoartrite assimétrica, predominando em grandes articulações como joelhos e tornozelos.
Profilaxia de trombose venosa profunda em cirurgia bariátrica
Authors: Boaventura Giovana Ribeiro , Moreira Leandro de Deus , Cardoso Hígor Chagas 
Published: December 2024

Obesidade é considerada uma epidemia mundial, sendo uma patologia caracterizada por aumento de gordura, levando a um estado de inflamação crônico, inflamaging. Existem vários tratamentos não farmacológicos e farmacológicos, mas o método cirúrgico, a é um dos mais eficaz no caso de pacientes que realizaram tratamentos convencionais e não obtiveram sucesso. A trombose venosa profunda (TVP) é causada pela coagulação do sangue no interior das veias, geralmente dos membros inferiores e uma das condições predisponentes é a obesidade e seu tratamento cirúrgico. Consequências graves podem ocorrer em decorrência, como embolias pulmonares, levando a risco de morte, e lesões nos vasos devido à inflamação. Existem diversos métodos de profilaxia para TVP, mas essas são subutilizadas ou são realizadas de maneira correta.
Uso de realidade virtual na redução da ansiedade e dor em procedimentos pediátricos
Authors: Ferreira Mariana Balestra de Andrade , Mendonça Giovana Guedes , Fontes Júlia Marcel Ghannam , Alves Laura de Souza , Pinto Renata Machado 
Published: December 2024

Intervenções em pacientes pediátricos podem causar ansiedade, estresse e dor, em especial quando envolvem punções. Anestesias são aplicadas para reduzir a experiência álgica e métodos lúdicos, como leituras e desenhos, já são tradicionalmente usados como distratores durante os procedimentos. Recentemente, a realidade virtual emergiu como uma alternativa para abrandar a ansiedade nesses pacientes.
Manejo cirúrgico em casos de necrose pancreática e complicações da pancreatite aguda: revisão de estratégias atualizadas
Authors: Silva Guilherme Henrique do Nascimento , Guimarães Neto João Carvalho , Costa Filho João Bosco da , Muniz Ana Carolyne Santos Freitas , Cardoso Diogo Gabriel Mendes Medeiros Silva , Silveira Filho Alex José , Mezzarano Giovanna Vieira , Almeida Louise Lemos , Tavares Maria Fernanda Novaes Rosa , Silva Lara Samira Abreu da , Costa Maria Clara Cruz Moraes 
Published: December 2024

Introdução: A pancreatite aguda (PA) pode progredir para formas graves, como a necrose pancreática, complicação que demanda intervenções cirúrgicas ou percutâneas. O manejo dessa condição evoluiu, com técnicas minimamente invasivas, como drenagem percutânea e necrosectomia vídeo-assistida, substituindo a necrosectomia aberta tradicional. Objetivo: Revisar as estratégias cirúrgicas mais recentes para o manejo da necrose pancreática, com ênfase nas técnicas minimamente invasivas e nos desfechos clínicos. Métodos: Trata-se de uma revisão de literatura na qual foram realizadas buscas na base de dados “Medline” via Biblioteca Virtual de Saúde (BVS). Os descritores utilizados foram “Necrose pancreática” AND “pancreatite aguda” AND “Cirurgia minimamente invasiva". Foram incluídos artigos originais, no idioma inglês, publicados nos últimos 5 anos (2019-2024). Resultados: Foram analisados 10 artigos, os quais preencheram os critérios de elegibilidade e foram selecionados para o resumo. Intervenções minimamente invasivas são preferidas no manejo da necrose pancreática infectada, pois resultam em menores complicações pós-operatórias e menor necessidade de reintervenções. A drenagem percutânea é frequentemente utilizada como primeira linha de tratamento, enquanto a necrosectomia vídeo-assistida é reservada para casos que não respondem à drenagem. O conceito de "espera vigilante", que adia a cirurgia até a estabilização hemodinâmica do paciente e melhor demarcação da necrose, tem sido amplamente aceito, contribuindo para melhores desfechos. Conclusão: O avanço das técnicas minimamente invasivas, associado ao manejo clínico intensivo e multidisciplinar, tem melhorado significativamente o prognóstico de pacientes com necrose pancreática. Novas tecnologias, como a cirurgia robótica e a pesquisa de agentes antimicrobianos, prometem revolucionar ainda mais o tratamento dessa condição complexa.