bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chinese visceral adiposity index, a novel indicator of visceral obesity for assessing the risk of incident hypertension in a prospective cohort study
Authors: Han Minghui , Qie Ranran , Li Quanman , Liu Leilei , Huang Shengbing , Wu Xiaoyan , Zhang Dongdong , Cheng Cheng , Zhao Yang , Liu Dechen , Guo Chunmei , Zhou Qionggui , Tian Gang , Zhang Yanyan , Wu Yuying , Li Yang , Yang Xingjin , Zhao Yang , Feng Yifei , Qin Pei , Hu Fulan , Zhang Ming , Hu Dongsheng 
Published: November 2020

AbstractThe present study aimed to investigate the association of the Chinese visceral adiposity index (CVAI) and its 6-year change with hypertension risk and compare the ability of CVAI and other obesity indices to predict hypertension based on the Rural Chinese Cohort Study. Study participants were randomly recruited by a cluster sampling procedure, and 10 304 participants ≥18 years were included. Modified Poisson regression was used to derive adjusted relative risks (RR) and 95 % CI. We identified 2072 hypertension cases during a median of 6·03 years of follow-up. The RR for the highest v. lowest CVAI quartile were 1·29 (95 % CI 1·05, 1·59) for men and 1·53 (95 % CI 1·22, 1·91) for women. Per-sd increase in CVAI was associated with hypertension for both men (RR 1·09, 95 % CI 1·02, 1·16) and women (RR 1·14, 95 % CI 1·06, 1·22). Also, the area under the receiver operating characteristic curve value for hypertension was higher for CVAI than the four other obesity indices for both sexes (all P < 0·05). Finally, per-sd increase in CVAI change was associated with hypertension for both men (RR 1·26, 95 % CI 1·16, 1·36) and women (RR 1·23, 95 % CI 1·15, 1·30). Similar results were observed in sensitivity analyses. CVAI and its 6-year change are positively associated with hypertension risk. CVAI has better performance in predicting hypertension than other visceral obesity indices for both sexes. The current findings suggest CVAI as a reliable and applicable predictor of hypertension in rural Chinese adults.
Interplay between productive traits, the social rank and the cow's stability in the order of entrance to the milking parlour
Authors: Vargas-Bello-Pérez E. , Bastías-Ruz J. , Toro-Mujica P. , Teixeira D.L. , Enriquez-Hidalgo D. 
Published: November 2020

AbstractThe aim of this study was to investigate whether social rank (SR) and stability in the order of entrance to the milking parlour are associated with production traits. The study was conducted on a dairy farm where cows (n= 215) were managed in three groups according to lactation stage (group 1: 78 cows, 0–100 days in milk (DIM); group 2: 65 cows, 101–200 DIM and group 3: 72 cows, >200 DIM). SR was calculated from observations made from agonistic behaviour performed at the water troughs and feed bunks of each pen (n= 3). The animals were classified into three levels of dominance based on at least five clear interactions, resulting in: 61 dominant, 75 intermediate and 69 subordinate cows based on SR. Stability in the order of entry was estimated as the standard deviation of the entry position. SR was weakly correlated with milk yield, urea and protein content in milk. The results showed that stable cows had higher milk production and entered the milking parlour after the non-stable animals. Stability in the order of entry to the milking parlour was not affected by SR. Overall, the use of milking facilities appears to be associated with production traits rather than SR.
Endonasal surgery in the coronavirus era – Birmingham experience
Authors: Naik P P , Tsermoulas G , Paluzzi A , McClelland L , Ahmed S K 
Published: November 2020

AbstractBackgroundThe World Health Organization declared coronavirus disease 2019 a pandemic on 11th March 2020. There is concern regarding performing endonasal surgical procedures because of a high viral load in the nasopharynx. This paper describes our experience in conducting emergency and urgent endonasal operations during the peak of the coronavirus disease 2019 pandemic in the UK.ObjectivesTo show the outcome of endonasal surgery during the peak of the coronavirus disease 2019 pandemic and to assess the post-operative rate of nosocomial coronavirus disease 2019 infection.MethodsA retrospective cohort study was conducted of all patients who underwent high priority endoscopic nasal surgery or anterior skull base surgery between 23rd March and 15th June 2020 at University Hospitals Birmingham NHS Trust.ResultsTwenty-four patients underwent endonasal surgery during the study period, 12 were males and 12 were females. There was no coronavirus-related morbidity in any patient.ConclusionThis observational study found that it is possible to safely undertake urgent endonasal surgery; the nosocomial risk of coronavirus disease 2019 can be mitigated with appropriate peri-operative precautions.
Development of a recombinase polymerase amplification (RPA-EXO) and lateral flow assay (RPA-LFA) based on the ITS1 gene for the detection of Angiostrongylus cantonensis in gastropod intermediate hosts
Authors: Jarvi Susan I. , Atkinson Elizabeth S. , Kaluna Lisa M. , Snook Kirsten A. , Steel Argon 
Published: November 2020

AbstractAngiostrongylus cantonensis is a parasitic nematode known to infect humans through the ingestion of third stage larvae which can cause inflammation and damage to the central nervous system. Currently, polymerase chain reaction (PCR) is one of the most reliable diagnostic methods for detecting A. cantonensis in humans as well as in gastropod hosts, but requires expensive and specialized equipment. Here, we compare the sensitivity and accuracy of a recombinase polymerase amplification Exo (RPA-EXO) assay, and a recombinase polymerase amplification lateral flow assay (RPA-LFA) with a traditional quantitative PCR (qPCR) assay currently available. The three assays were used to test 35 slugs from Hawai‘i for the presence of A. cantonensis DNA. Consistent results among the three tests were shown in 23/35 samples (65.7%), while 7/35 (20%) were discordant in low infection level samples (<0.01 larvae per mg tissue), and 5/35 (14.3%) were equivocal. To evaluate sensitivity, a partial ITS1 gene was cloned, and serial plasmid dilutions were created ranging from 100 copies μL−1 to ~1 copy μL−1. All three assays consistently detected 50–100 copies μL−1 in triplicate and qPCR was able to detect ~13 copies μL−1 in triplicate. RPA-EXO was able to detect 25 copies μL−1 in triplicate and RPA-LFA was not able to amplify consistently below 50 copies μL−1. Thus, our RPA-EXO and RPA-LFA assays do not appear as sensitive as the current qPCR assay at low DNA concentrations; however, these tests have numerous advantages that may make them useful alternatives to qPCR.
Does providing personalized depression risk information lead to increased psychological distress and functional impairment? Results from a mixed-methods randomized controlled trial
Authors: Wang JianLi , Eccles Heidi , Nannarone Molly , Schmitz Norbert , Patten Scott , Lashewicz Bonnie 
Published: November 2020

AbstractBackgroundMultivariable risk algorithms (MVRP) predicting the personal risk of depression will form an important component of personalized preventive interventions. However, it is unknown whether providing personalized depression risk will lead to unintended psychological harms. The objectives of this study were to evaluate the impact of providing personalized depression risk on non-specific psychological distress and functional impairment over 12 months.MethodsA mixed-methods randomized controlled trial was conducted in 358 males and 354 females who were at high risk of having a major depressive episode according to sex-specific MVRPs, and who were randomly recruited across Canada. Participants were assessed at baseline, 6 and 12 months.ResultsOver 93% of participants were interested in knowing their depression risk. The intervention group had a greater reduction in K10 score over 12 months than the control group; complete-case analysis found a significant between-group difference in mean K10 change score (d = 1.17, 95% CI 0.12–2.23) at 12 months. Participants in the intervention group also reported significantly less functional impairment in the domains of home and work/school activities, than did those in the control group. A majority of the qualitative interviewees commented that personalized depression risk information does not have a negative impact on physical and mental health.ConclusionsThis study found no evidence that providing personalized depression risk information will lead to worsening psychological distress, functional impairment, and absenteeism. Provision of personalized depression risk information may have positive impacts on non-specific psychological distress and functioning.Trial registrationClinicalTrials.gov NCT02943876
A debris-covered glacier at Kerguelen (49°S, 69°E) over the past 15 000 years
Authors: Charton Joanna , Jomelli Vincent , Schimmelpfennig Irene , Verfaillie Deborah , Favier Vincent , Mokadem Fatima , Gilbert Adrien , Brun Fanny , Aumaître Georges , Bourlès Didier L. , Keddadouche Karim 
Published: November 2020

AbstractDebris-covered glaciers constitute a large part of the world's cryosphere. However, little is known about their long-term response to multi-millennial climate variability, in particular in the Southern Hemisphere. Here, we provide first insights into the response of a debris-covered glacier to multi-millennial climate variability in the sub-Antarctic Kerguelen Archipelago, which can be compared to that of recently investigated debris-free glaciers. We focus on the Gentil Glacier and present 13 new 36Cl cosmic-ray exposure ages from moraine boulders. The Gentil Glacier experienced at least two glacial advances: the first one during the Late Glacial (19.0–11.6 ka) at ~14.3 ka and the second one during the Late Holocene at ~2.6 ka. Both debris-covered and debris-free glaciers advanced broadly synchronously during the Late Glacial, most probably during the Antarctic Cold Reversal event (14.5–12.9 ka). This suggests that both glacier types at Kerguelen were sensitive to abrupt temperature changes recorded in Antarctic ice cores, associated with increased moisture. However, during the Late Holocene, the advance at ~2.6 ka was not observed in other glaciers and seems to be an original feature of the debris-covered Gentil Glacier, related to either distinct dynamics or to distinct sensitivity to precipitation changes.
Neurodevelopmental evaluation for school-age children with congenital heart disease: recommendations from the cardiac neurodevelopmental outcome collaborative
Authors: Ilardi Dawn , Sanz Jacqueline H. , Cassidy Adam R. , Sananes Renee , Rollins Caitlin K. , Ullman Shade Catherine , Carroll Gretchen , Bellinger David C. 
Published: November 2020

AbstractIn 2012, the American Heart Association and the American Academy of Paediatrics released a scientific statement with guidelines for the evaluation and management of the neurodevelopmental needs of children with CHD. Decades of outcome research now highlight a range of cognitive, learning, motor, and psychosocial vulnerabilities affecting individuals with CHD across the lifespan. The number of institutions with Cardiac Neurodevelopmental Follow-Up Programmes and services for CHD is growing worldwide. This manuscript provides an expanded set of neurodevelopmental evaluation strategies and considerations for professionals working with school-age children with CHD. Recommendations begin with the referral process and access to the evaluation, the importance of considering medical risk factors (e.g., genetic disorders, neuroimaging), and the initial clinical interview with the family. The neurodevelopmental evaluation should take into account both family and patient factors, including the child/family’s primary language, country of origin, and other cultural factors, as well as critical stages in development that place the child at higher risk. Domains of assessment are reviewed with emphasis on target areas in need of evaluation based on current outcome research with CHD. Finally, current recommendations are made for assessment batteries using a brief core battery and an extended comprehensive clinical battery. Consistent use of a recommended assessment battery will increase opportunities for research collaborations, and ultimately help improve the quality of care for families and children with CHD.
Re-examining the effect of phonological similarity between the native- and second-language intonational systems in second-language speech segmentation
Authors: Tremblay Annie , Kim Sahyang , Shin Seulgi , Cho Taehong 
Published: November 2020

AbstractThis study investigates how phonological and phonetic aspects of the native-language (L1) intonation modulate the use of tonal cues in second-language (L2) speech segmentation. Previous research suggested that prosodic learning is more difficult if the L1 and L2 intonations are phonologically similar but phonetically different (French–Korean) than if they are phonologically different (English–French/Korean) (Prosodic-Learning Interference Hypothesis; Tremblay, Broersma, Coughlin & Choi, 2016). This study provides another test of this hypothesis. Korean listeners and French-speaking and English-speaking L2 learners of Korean in Korea completed an eye-tracking experiment investigating the effects of phrase tones in Korean. All groups patterned similarly with the phrase-final tone, but, unlike Korean and French listeners, English listeners showed early benefits from the phrase-initial tone (signaling word-initial boundaries in English). Importantly, French listeners patterned like Korean listeners with both tones. The Prosodic-Learning Interference Hypothesis is refined to suggest that prosodic learning difficulties may not be persistent for immersed L2 learners.
Unhealthy food options in the school environment are associated with diet quality and body weights of elementary school children in Canada
Authors: Sim Shannon , Veugelers Paul J , Prowse Rachel , Nykiforuk Candace IJ , Maximova Katerina 
Published: November 2020

AbstractObjective:Increasing evidence links unhealthy food environments with diet quality and overweight/obesity. Recent evidence has demonstrated that relative food environment measures outperform absolute measures. Few studies have examined the interplay between these two measures. We examined the separate and combined effects of the absolute and relative densities of unhealthy food outlets within 1600 m buffers around elementary schools on children’s diet- and weight-related outcomes.Design:This is a cross-sectional study of 812 children from thirty-nine schools. The Youth Healthy Eating Index (Y-HEI) and daily vegetables and fruit servings were derived from the Harvard Food Frequency Questionnaire for Children and Youth. Measured heights and weights determined BMI Z-scores. Food outlets were ranked as healthy, somewhat healthy and unhealthy according to provincial paediatric nutrition guidelines. Multilevel mixed-effects regression models were used to assess the effect of absolute (number) and relative (proportion) densities of unhealthy food outlets within 1600 m around schools on diet quality and weight status.Setting:Two urban centres in the province of Alberta, Canada.Participants:Grade 5 students (10–11 years).Results:For children attending schools with a higher absolute number (36+) of unhealthy food outlets within 1600 m, every 10 % increase in the proportion of unhealthy food outlets was associated with 4·1 lower Y-HEI score and 0·9 fewer daily vegetables and fruit.Conclusions:Children exposed to a higher relative density of unhealthy food outlets around a school had lower diet quality, specifically in areas where the absolute density of unhealthy food outlets was also high.
Services Trade Policies and Economic Integration: New Evidence for Developing Countries
Authors: Hoekman Bernard , Shepherd Ben 
Published: November 2020

AbstractThis paper applies machine learning to recreate to a high degree of accuracy the OECD's Services Trade Restrictiveness Index (STRI) to provide quantitative evidence on the restrictiveness of services policies in 2016 for a sample of developing countries, using regulatory data collected by the World Bank and WTO. Resulting estimates are used to extend the OECD STRI approach to 23 additional countries, producing what we term a Services Policy Index (SPI). Converting the SPI to ad valorem equivalent terms shows that services policies are typically much more restrictive than tariffs on imports of goods, in particular in professional services and telecommunications. The SPI has strong explanatory power for bilateral trade in services at the sectoral level, as well as for aggregate goods and services trade.
Cardiorespiratory fitness is positively associated with both healthy and western dietary pattern in Iranian middle-aged
Authors: Shahinfar Hossein , Djafari Farhang , Babaei Nadia , Davarzani Samira , Ebaditabar Mojdeh , Clark Cain C. T. , Djafarian Kurosh , Imani Hossein , Shab-Bidar Sakineh 
Published: November 2020

Abstract. Background: The association between dietary patterns and cardiorespiratory fitness (CRF) is not well established. Objective: We sought to investigate association between a posteriori dietary pattern and CRF in middle-aged adults. Design: Adults (n = 276), aged 20–74 years, who were residents of Tehran, Iran were recruited. Diet was assessed by using a validated 168-item semi-quantitative food frequency questionnaire. Principal component analysis was used to derive dietary patterns. Socio-economic status, anthropometric measures, body composition, and blood pressure were recorded. CRF was assessed by using a graded exercise treadmill test. Analysis of variance and linear regression models were used to discern the association between dietary patterns and CRF. Results: Higher scores of the healthy dietary pattern had no association with VO2max(p = 0.13 ). After controlling for potential confounders, VO2maxwas positively associated across tertiles of healthy dietary patterns (p < 0.001). Higher adherence to the “mixed” dietary pattern was inversely related to VO2max(p < 0.01). After adjusting for confounders, the significant association disappeared (p = 0.14). Higher scores of the “Western” dietary pattern was not associated with VO2max(p = 0.06). However, after controlling for potential confounders, VO2maxwas positively associated with the “Western” dietary pattern (p = 0.01). A positive linear association between the “healthy” dietary pattern and CRF for the total sample (R2 = 0.02; p < 0.01) were presented. Conclusions: Overall, our findings suggest that higher adherence to a “healthy” and “Western” dietary pattern was positively associated with CRF. However, further studies are required to examine and clarify the causal relationship between dietary patterns and CRF.
Experimental Simulations of Hypervelocity Impact Penetration of Asteroids Into the Terrestrial Ocean and Benthic Cratering
Authors: Nishizawa Manabu , Matsui Yohei , Suda Konomi , Saito Takuya , Shibuya Takazo , Takai Ken , Hasegawa Sunao , Yano Hajime 
Published: November 2020

AbstractSeafloor cratering is an important process that records the impact history of the Earth, affects projectile survivability, and determines the mass of ejecta from benthic rock that is transported to the atmosphere. We report experimental hypervelocity impacts of chondrite and other projectiles (olivine, stainless‐steel, polycarbonate) on a water‐covered iron target to derive a scaling relationship for benthic cratering. In situ observations of 5‐km/s impacts quantify the deceleration of projectiles in the water column by shock‐induced deformation and fragmentation. The minimum water depths at which multiple craters appeared on the benthic target were two and four times the projectile diameter for chondrite and stainless steel, respectively. Based on the observed deceleration of projectiles in water, the cratering efficiency of a benthic target for a given impact velocity is predicted to follow an exponential decay law in terms of water depth normalized by projectile diameter (H/d), given by πv ∝ exp(−(H/d)/κ), when a projectile of original mass collides with the target. Comparing the volume of the largest crater in the experiments and that derived from the scaling relation, mass ratios of the largest projectile fragment to original projectile in the 5‐km/s impact were calculated to be 0.1–0.3 (H/d = 2–6) and 1.0 ± 0.3 (H/d = 5.5) for chondrite and stainless steel, respectively. Using the scaling relationship, the volume of the transient crater on oceanic crust by an asteroid impact is estimated to be smaller than previously predicted by hydrocode simulation when the asteroid fragmentation in the water column controls seafloor cratering.
Global Ocean Mass Change From GRACE and GRACE Follow‐On and Altimeter and Argo Measurements
Authors: Chen Jianli , Tapley Byron , Wilson Clark , Cazenave Anny , Seo Ki‐Weon , Kim Jae‐Seung 
Published: November 2020

AbstractSatellite altimeter sea surface heights, in combination with Argo ocean temperature and salinity observations, provide an independent measure of global mean ocean mass (GMOM) change. Over the period January 2005 to April 2020, GMOM rates observed by the Gravity Recovery and Climate Experiment (GRACE) and GRACE Follow‐On (GFO) range from 1.88 ± 0.10 to 2.63 ± 0.10 mm/year, compared to 2.85 ± 0.37 mm/year from Altimeter‐Argo. Over much of the GRACE era, GRACE GMOM estimates agree well with Altimeter‐Argo over a broadband of frequencies. However, during the late stage of the GRACE mission (after August 2016) and into the GFO era, differences between GRACE/GFO and Altimeter‐Argo GMOM estimates become substantially larger and systematic, which may be related to the single accelerometer mode of operation during late‐stage GRACE and GFO missions and/or errors of Argo and altimeter data.
Mutant TP53 interacts with BCAR1 to contribute to cancer cell invasion
Authors: Guo Alvin Kunyao , Itahana Yoko , Seshachalam Veerabrahma Pratap , Chow Hui Ying , Ghosh Sujoy , Itahana Koji 
Published: November 2020

Abstract
Background
Mutant TP53 interacts with other proteins to produce gain-of-function properties that contribute to cancer metastasis. However, the underlying mechanisms are still not fully understood.

Methods
Using immunoprecipitation and proximity ligation assays, we evaluated breast cancer anti-estrogen resistance 1 (BCAR1) as a novel binding partner of TP53R273H, a TP53 mutant frequently found in human cancers. The biological functions of their binding were examined by the transwell invasion assay. Clinical outcome of patients was analysed based on TP53 status and BCAR1 expression using public database.

Results
We discovered a novel interaction between TP53R273H and BCAR1. We found that BCAR1 translocates from the cytoplasm into the nucleus and binds to TP53R273H in a manner dependent on SRC family kinases (SFKs), which are known to enhance metastasis. The expression of full-length TP53R273H, but not the BCAR1 binding-deficient mutant TP53R273HΔ102–207, promoted cancer cell invasion. Furthermore, among the patients with mutant TP53, high BCAR1 expression was associated with a poorer prognosis.

Conclusions
The interaction between TP53R273H and BCAR1 plays an important role in enhancing cancer cell invasion. Thus, our study suggests a disruption of the TP53R273H–BCAR1 binding as a potential therapeutic approach for TP53R273H-harbouring cancer patients.