bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of interventions to increase uptake and completion of treatment for diabetic retinopathy in low- and middle-income countries: a rapid review protocol.
Authors: Bascaran Covadonga , Mwangi Nyawira , D’Esposito Fabrizio , Cleland Charles , Gordon Iris , Ulloa Juan Alberto Lopez , Maswadi Ranad , Md Shaffi , Ramke Jacqueline , Evans Jennifer R , Burton Matthew 
Published: December 2020

Abstract
BackgroundVision loss due to diabetic retinopathy can largely be prevented or delayed through treatment. Patients with vision-threatening diabetic retinopathy are typically offered laser or intravitreal injections which often require more than one treatment cycle. However, treatment is not always initiated, or it is not completed, resulting in poor visual outcomes. Interventions aimed at improving the uptake or completion of treatment for diabetic retinopathy can potentially help prevent or delay visual loss in people with diabetes. MethodsWe will search MEDLINE, Embase, Global Health and Cochrane Register of Studies for studies reporting interventions to improve the uptake of treatment for diabetic retinopathy (DR) and/or diabetic macular oedema (DMO), compared with usual care, in adults with diabetes. The review will include studies published in the last 20 years in the English language. We will include any study design that measured any of the following outcomes in relation to treatment uptake and completion for DR and/or DMO: 1) Proportion of patients initiating treatment for DR and/or DMO among those to whom it is recommended, 2) Proportion of patients completing treatment for DR and/or DMO among those to whom it is recommended, 3)Proportion of patients completing treatment for DR and/or DMO among those initiating treatment, 4) Number and proportion of DR and/or DMO rounds of treatment completed per patient, as dictated by the treatment protocol. For included studies we will also report any measures of cost-effectiveness when available. Two reviewers will screen search results independently. Risk of bias assessment will be done by two reviewers and data extraction will be done by one reviewer with verification of 10% of the papers by a second reviewer. The results will be synthesised narratively.DiscussionThis rapid review aims to identify and synthesise the peer-reviewed literature on the effectiveness of interventions to increase uptake and completion of treatment for DR and/or DMO in LMICs. The rapid review methodology was chosen in order to rapidly synthesise the available evidence to support program implementers and policy makers in designing evidence-based health programs, public health policy, and inform the allocation of resources. Rapid review registration: OSF: osf.io/h5wgr
The impact of individual creativity, psychological capital, and leadership autonomy support on hospital employees’ innovative behaviour
Authors: Slåtten Terje , Mutonyi Barbara Rebecca , Lien Gudbrand 
Published: December 2020

Abstract
Background: There is growing interest in and focus on healthcare services research to identify factors associated with innovation in healthcare organizations. However, previous innovation research has concentrated primarily on the organizational level. In contrast, this study focuses on innovation by individual employees. The specific aim is to examine factors with potential impact on individual employee innovation in hospital organizations. Thus, the study significantly deepens and broadens previous research on innovation in the domain of health services.Methods: A conceptual model was developed and tested on a sample of hospital employees (n=1008). Partial least-squares structural equation modelling (PLS-SEM) was used to analyse the data with SmartPLS 3 software in two steps involving a measurement model and a structural model. Mediation analysis was used to test the proposed indirect effects.Results: Hospital employees’ individual innovative behaviour is directly and positively associated with individual creativity (b = 0.440), psychological capital (b = 0.34) and leadership autonomy support (b = 0.07). The relationships between leadership autonomy support, psychological capital and individual innovative behaviour are all mediated by employees’ creativity. Psychological capital mediates the relationship between leadership autonomy support and individual innovative behaviour. Overall, the proposed model explains 50% of the variance in hospital employees’ innovative behaviour.Conclusions: This study reveals a complex pattern of links between innovative behaviour and leadership autonomy support, employees’ creativity and employees’ psychological capital. However, the findings indicate that leadership autonomy support has an influential and multifaceted impact on hospital employees’ innovative behaviour.
Safely reducing haemodialysis frequency during the COVID-19 pandemic
Authors: Lodge Michelle da Silva , Abeygunaratne Thilini , Alderson Helen , Ali Ibrahim , Brown Nina , Chrysochou Constantina , Donne Rosie , Erekosima Ibi , Evans Philip , Flanagan Emma , Gray Simon , Green Darren , Hegarty Janet , Hyde Audrey , Kalra Philip A , Lamerton Elizabeth , Lewis David , Middleton Rachel , New David , Nipah Robert , O’Donoghue Donal , O’Riordan Edmond , Poulikakos Dimitrios , Rainone Francesco , Raman Maharajan , Ritchie James , Sinha Smeeta , Wood Grahame , Tollitt James 
Published: December 2020

Abstract
Background:Patients undergoing haemodialysis (HD) are at higher risk of developing worse outcomes if they contract COVID-19. In our renal service we reduced HD frequency from thrice to twice-weekly in selected patients with the primary aim of reducing COVID 19 exposure and transmission between HD patients.Methods:Dialysis unit nephrologists identified 166 suitable patients (38.4% of our HD population) to temporarily convert to twice-weekly haemodialysis immediately prior to the peak of the COVID-19 pandemic in our area. Changes in pre-dialysis weight, systolic blood pressure (SBP) and biochemistry were recorded weekly throughout the 4-week project. Hyperkalaemic patients (serum potassium > 6.0mmol/L) were treated with a potassium binder, sodium bicarbonate and received responsive dietary advice.Results:There were 12 deaths (5 due to COVID-19) in the HD population, 6 of which were in the twice weekly HD group; no deaths were definitively associated with change of dialysis protocol. A further 19 patients were either hospitalised and/or developed COVID-19 and thus transferred back to thrice weekly dialysis as per protocol. 113 (68.1%) were still receiving twice-weekly HD by the end of the 4-week project. Indications for transfer back to thrice weekly were; fluid overload (19), persistent hyperkalaemia (4), patient request (4) and compliance (1). There were statistically significant increases in SBP and pre-dialysis potassium during the project. Conclusions:Short term conversion of a large but selected HD population to twice-weekly dialysis sessions was possible and safe. This approach could help mitigate COVID-19 transmission amongst dialysis patients in centres with similar organisational pressures.
Frequent avoidable admissions amongst Aboriginal and non-Aboriginal people with chronic conditions in New South Wales, Australia: a historical cohort study
Authors: Jayakody Amanda Anne , Oldmeadow Christopher , Carey Mariko , Bryant Jamie , Evans Tiffany , Ella Stephen , Attia John , Towle Simon , Sanson-Fisher Robert 
Published: December 2020

Abstract
Background: Aboriginal and Torres Strait Islander people have high rates of avoidable hospital admissions for chronic conditions, however little is known about the frequency of avoidable admissions for this population. This study examined trends in avoidable admissions among Aboriginal and non-Aboriginal people with chronic conditions in New South Wales (NSW), Australia. Methods: A historical cohort analysis using de-identified linked administrative data of Aboriginal patients and an equal number of randomly sampled non-Aboriginal patients between 2005/06 to 2013/14. Eligible patients were admitted to a NSW public hospital and who had one or more of the following ambulatory care sensitive chronic conditions as a principal diagnosis: diabetic complications, asthma, angina, hypertension, congestive heart failure and/or chronic obstructive pulmonary disease. The primary outcomes were the number of avoidable admissions for an individual in each financial year, and whether an individual had three or more admissions compared with one to two avoidable admissions in each financial year. Poisson and logistic regression models and a test for differences in yearly trends were used to assess the frequency of avoidable admissions over time, adjusting for sociodemographic variables and restricted to those aged ≤75 years.Results: Once eligibility criteria had been applied, there were 27,467 avoidable admissions corresponding to 19,025 patients between 2005/06 to 2013/14 (71.2% Aboriginal; 28.8% non-Aboriginal). Aboriginal patients were 15% more likely than non-Aboriginal patients to have a higher number of avoidable admissions per financial year (IRR=1.15; 95% CI: 1.11, 1.20). Aboriginal patients were almost twice as likely as non-Aboriginal patients to experience three or more avoidable admissions per financial year (OR=1.90; 95% CI=1.60, 2.26). There were no significant differences between Aboriginal and non-Aboriginal people in yearly trends for either the number of avoidable admissions, or whether or not an individual experienced three or more avoidable admissions per financial year (p=0.859; 0.860 respectively). Conclusion: Aboriginal people were significantly more likely to experience frequent avoidable admissions over a nine-year period compared to non-Aboriginal people. These high rates reflect the need for further research into which interventions are able to successfully reduce avoidable admissions among Aboriginal people, and the importance of culturally appropriate community health care.
How implementation of a national strategy for nursing homes is experienced by the healthcare personnel: A qualitative study with content analysis of interviews.
Authors: Andre Beate , Grønning RN. Kjersti , Jacobsen Frode F. , Haugan Gørill 
Published: December 2020

Abstract
Background: Nursing homes are under strong pressure to provide good care to the residents. In Norway, municipalities have applied the ‘Joy-of-Life-Nursing-Home’ strategy to increase a health-promoting perception that focuses on the older persons` resources. Implementations represent introducing changes to the healthcare personnel; however, changing one’s working approaches, routines and working culture may be demanding. On this background, we explored how the ‘Joy-of-Life-Nursing-Home’ strategy is perceived by the employees in retrospective, over a period after the implementation and which challenges the employees experience with this implementation.Method: We used a qualitative approach and interviewed 14 healthcare personnel working in nursing homes in one Norwegian municipality, which had implemented the ‘Joy-of-Life-Nursing-Home’ strategy. The analysis was conducted following Kvale’s approach to qualitative content analysis.Results: The main categories were: (a) the characteristics of care activities before implementations of ‘Joy-of-Life-Nursing-Home’, (b) how ‘Joy-of-Life-Nursing-Home’ influenced the care activities, and (c) challenges with the implementation of ‘Joy-of-Life-Nursing-Home’. Some of the informants spoke well about the implementation concerning the care quality stating “to see the joy in the eyes of the resident then I feel we have succeeded”. For informants who experienced resistance toward the implementation, they felt it was too much to document, it was too complicated, and the requirements were too many. Conclusions: Quality of care seems to have increased after the implementation, as perceived by the informants. Nevertheless, the fact that the informants seemed to be divided into two different groups related to their main perspective of the implementation is concerning. One group has positive experiences with the implementations process and the benefits of it, while the other group focuses on lack of benefits and problems with the implementation process. In order to understand what facilitates and hinders the implementation, research on contextual factors like work environment and leadership is recommended.
The effect of preoperative chemotherapy on liver regeneration after portal vein embolization/ligation or liver resection in patients with colorectal liver metastasis: a systematic review protocol
Authors: Pavel Mihai-Calin , Casanova Raquel , Estalella Laia , Memba Robert , Llàcer-Millán Erik , Achalandabaso Mar , Julià Elisabet , Geoghegan Justin , Jorba Rosa 
Published: December 2020

Abstract
Introduction: Liver resection (LR) in patients with liver metastasis from colo-rectal cancer remains the only curative treatment. Perioperative chemotherapy improves prognosis of these patients. However, there are concerns regarding the effect of preoperative chemotherapy on liver regeneration, which is a key event in avoiding liver failure after LR. The primary objective of this systematic review is to assess the effect of neoadjuvant chemotherapy on liver regeneration after (LR) or portal vein embolization (PVE) in patients with liver metastasis from colo-rectal cancer. The secondary objectives are to evaluate the impact of the type of chemotherapy, number of cycles and time between end of treatment and procedure (LR or PVE) and to investigate whether there is an association between degree of hypertrophy and postoperative liver failure.Methods: This meta-analysis will include studies reporting liver regeneration rates in patients submitted to LR or PVE. Pubmed, Scopus, Web of Science, Embase and Cochrane databases will be searched. Only studies comparing neoadjuvant vs no chemotherapy, or comparing chemotherapy characteristics (bevacizumab administration, number of cycles and time from finishing chemotherapy until intervention) will be included. We will select studies from 1990 to present. Two researchers will individually screen the identified records, according to a list of inclusion and exclusion criteria. Primary outcome will be future liver remnant regeneration rate. Bias of the studies will be evaluated with the ROBINS-I tool and quality of evidence for all outcomes will be determined with the GRADE system. The data will be registered in a predesigned database. If selected studies are sufficiently homogeneous, we will perform a meta-analysis of reported results. In the event of a substantial heterogeneity, a qualitive systematic review will be performed.Discussion: The results of this systematic review may help to better identify the patients affected by liver metastasis that could present low regeneration rates after neoadjuvant chemotherapy. These patients are at risk to develop liver failure after extended hepatectomies and therefore are not good candidates for such aggressive procedures.Systematic Review Registration: PROSPERO registration number: CRD42020178481 (July 5th 2020).
Characteristics of the completed chloroplast genome sequence of Xanthium spinosum: Comparative analyses, identification of mutational hotspots and phylogenetic implications
Authors: Raman Gurusamy , Park KyuTae , Kim Joo Hwan , Park SeonJoo 
Published: December 2020

Abstract
Background: The invasive species Xanthium spinosum has been used as a traditional Chinese medicine for many years. Unfortunately, no extensive molecular studies of this plant have been conducted. Results: Here, the complete chloroplast (cp) genome sequence of X. spinosum was assembled and analyzed. The cp genome of X. spinosum was 152,422 base pairs (bp) in length, with a quadripartite circular structure. The cp genome contained 115 unique genes, including 80 PCGs, 31 tRNA genes, and 4 rRNA genes. Comparative analyses revealed that X. spinosum contains a large number of repeats (999 repeats) and 701 SSRs in its cp genome. Fourteen divergences (Π > 0.03) were found in the intergenic spacer regions. Phylogenetic analyses revealed that Parthenium is a sister clade to both Xanthium and Ambrosia and an early-diverging lineage of subtribe Ambrosiinae, although this finding was supported with a very weak bootstrap value. Conclusion: The identified hotspot regions could be used as molecular markers for resolving phylogenetic relationships and species identification in the genus Xanthium.
H2V, a database for human genes and proteins in response to SARS-CoV-2, SARS-CoV, and MERS-CoV infection
Authors: Zhou Nan , Bao Jinku , Ning Yuping 
Published: December 2020

Abstract
The ongoing COVID-19 pandemic in the world is caused by SARS-CoV-2, a new coronavirus first discovered in the end of 2019. It has led to more than 50 million confirmed cases and more than 1 million deaths across 219 countries by 11 November 2020, according to the WHO statistics. SARS-CoV-2, SARS-CoV, and MERS-CoV are alike. They are highly pathogenic, and they threaten public health, impair economy, and inflict long-term impacts on the society. No drug or vaccine has been approved as a cure for these viruses. The efforts to develop antiviral measures are hampered by the insufficient understanding of how the human body responds to viral infections at the cellular and molecular levels. In this study, journal articles and transcriptomic and proteomic data that survey coronavirus infections were collected. Response genes and proteins were then identified via differential analyses which compared the gene/protein between the infected sample and control. A database, H2V, was finally created for human genes/proteins responding to SARS-CoV-2, SARS-CoV, and MERS-CoV infection. H2V provides the molecular information about human response to infection. It can be a powerful tool to discover cellular pathways and processes relevant for viral pathogenesis to identify potential drug targets. It is expected to speed up the process of developing antiviral agents and to shed light on the preparation for potential coronavirus emergency in the future.
Mixed Halide Perovskites for High-Efficiency and Spectrally Stable Blue Light-Emitting Diodes
Authors: Karlsson Max , Yi Ziyue , Reichert Sebastian , Luo Xiyu , Lin Weihua , Lin Zeyu , Bao Chunxiong , Zhang Rui , Bai Sai , Zheng Guanhaojie , Teng Pengpeng , Duan Lian , Lu Yue , Zheng Kaibo , Pullerits Tonu , Deibel Carsten , xu weidong , Friend Richard , Gao Feng 
Published: December 2020

Abstract
Bright and efficient blue emission is key to further development of metal halide perovskite light-emitting diodes. Although modifying bromide/chloride composition is straightforward to achieve blue emission, practical implementation of this strategy has been challenging due to poor colour stability and severe photoluminescence quenching. Both detrimental effects become increasingly prominent in perovskites with the high chloride content that is desired to produce blue emission. Here, we solve these critical challenges in mixed halide perovskites and demonstrate spectrally stable blue perovskite light-emitting diodes (PeLEDs) over a wide range of emission wavelengths from 490 to 451 nanometres. The emission colour is directly tuned by modifying the halide composition. Particularly, our blue and deep-blue PeLEDs based on three-dimensional perovskites show high EQE values of 11.0% and 5.5% with emission peaks at 477 and 467 nm, respectively. These achievements are enabled by a vapour-assisted crystallization technique, which largely mitigates local compositional heterogeneity and ion migration.
Selective catalysis remedies polysulfide shuttling in lithium-sulfur batteries
Authors: Hua Wuxing , Li Huan , Pei Chun , Xia Jingyi , Sun Yafei , Zhang Chen , Lv Wei , Tao Ying , Jiao Yan , Zhang Bingsen , Qiao Shizhang , Wan Ying , Yang Quan-Hong 
Published: December 2020

Abstract
The shuttling of soluble lithium polysulfides between the electrodes leads to serious capacity fading and excess use of electrolyte, which severely bottlenecks practical use of Li-S batteries. Here selective catalysis is proposed as a fundamental remedy for the consecutive solid-liquid-solid sulfur redox reactions. The proof-of-concept In2O3 catalyst targetedly slows down the solid-liquid conversion, dissolution of elemental sulfur to polysulfides, while accelerates the liquid-solid conversion, deposition of polysulfides into insoluble Li2S, which basically reduces accumulation of polysulfides in electrolyte, finally inhibiting the shuttle effect. The selective catalysis is revealed, experimentally and theoretically, by changes of activation energies and kinetic currents, modified reaction pathway together with the probed LiInS2 intermediates, and gradual deactivation of the catalyst. The In2O3-catalysed Li-S battery works steadily over 1000 cycles at 4.0 C and yields an initial areal capacity up to 9.4 mAh cm−2 with a sulfur loading of ~9.0 mg cm−2.
In-line coagulation assessment for ultrafiltration fouling reduction to treat secondary effluent for water reuse
Authors: Aly Samia A. , Anderson William B. , Huck Peter M. 
Published: December 2020

Abstract
Low pressure membranes are attracting attention for their potential to improve secondary effluent quality, but membrane fouling can limit their widespread applicability. In this study, in-line coagulation as pre-treatment to ultrafiltration (UF) was investigated using a bench-scale hollow fiber membrane at a constant flux of 33 L/m2 h. Membrane fouling was monitored by observing change in trans-membrane pressure when the membrane was fed with secondary effluent and in-line coagulated secondary effluent over a 24-h period. The impact of four coagulants at different dosages on reversible and irreversible membrane fouling and permeate quality was studied. It was found that in-line coagulation improved UF performance to varying degrees depending on coagulant type and dosage. Generally, higher reduction of fouling was achieved by increasing coagulant dosage within the 0.5–5.0 mg/L range investigated. Ferric-based coagulants were better than aluminum-based coagulants with respect to improving membrane performance for the secondary effluent investigated, even at low dosages (0.5 mg/L). Further investigations are required to determine how in-line coagulation affects removal of organic compounds through UF membranes.