bluuebunny/crossref_metadata_2025_split huggingface dataset:
ЗНАЧЕНИЕ АНГИОГЕНЕЗА В ПРОГНОЗЕ РЕЦИДИВИРОВАНИЯ И ПРОГРЕССИИ НЕИНВАЗИВНОГО УРОТЕЛИАЛЬНОГО РАКА МОЧЕВОГО ПУЗЫРЯ.
Authors: Яковцова И. И. , Титов Е. В. , Ивахно И. В. 
Published: October 2019

Резюме. Целью работы являлось изучение ангиогенеза в неинвазивных уротелиальных раках мочевого пузыря (НУРМП) для выявления критериев рецидивирования и прогрессии заболевания.
Материалы и методы. Материалом послужили оперативно удаленные в Харьковском областном клиническом центре урологии и нефрологии им. В. И. Шаповалова уротелиальные раки мочевого пузыря стадии T1, то есть без инвазии в мышечный слой стенки органа, числом 42 случая. Средний возраст пациентов составил 66,4±7,2 лет, мужчин было 83,3% (35/42), женщин –16,7% (7/42).
Материал был распределён на группы: НУРМП без рецидивирования – I группа (14 случаев), НУРМП с рецидивированием без прогрессии – II группа (14 случаев) и НУРМП с рецидивированием и прогрессией в виде инвазии в мышечный слой стенки – III группа (14 случаев).
Результаты и их обсуждение. ПМС в НУРМП составила 32,71±4,22 и варьировала от 12,8 до 44,6. ПМС в строме НУРМП повышалась при возрастании степени злокачественности опухоли, но уровень васкуляризации не оказывал прямого влияния на прогноз заболевания. В НУРМП высокой степени злокачественности отмечалась более интенсивная экспрессия VEGF и большее значение ПМС, чем в НУРМП низкой степени злокачественности (р<0,03 и р<0,01 соответственно). Различия между группами исследования по показателям ПМС и экспрессии VEGF не достоверны (р>0,05).
Выводы. Подтверждена роль VEGF в неоангиогенезе НУРМП, что определяется прямой корреляционной зависимостью между уровнем экспрессии VEGF и ПМС (r=0,677, р<0,05). По мере снижения дифференцировки НУРМП отмечается возрастание васкуляризации опухоли (р<0,01), что обусловлено возрастанием экспрессии VEGF опухолевыми клетками (р<0,03). Исследованные показатели неоангиогенеза – ПМС и VEGF – имеют ограниченное значение для прогноза рецидивирования и прогрессии НУРМП.
Evidence on User-Led Innovation in Diabetes Technology (The OPEN Project): Protocol for a Mixed Methods Study
Authors: O'Donnell Shane , Lewis Dana , Marchante Fernández María , Wäldchen Mandy , Cleal Bryan , Skinner Timothy , Raile Klemens , Tappe Adrian , Ubben Tebbe , Willaing Ingrid , Hauck Bastian , Wolf Saskia , Braune Katarina 
Published: October 2019

Background
Digital innovations in health care have traditionally followed a top-down pathway, with manufacturers leading the design and production of technology-enabled solutions and those living with chronic conditions involved only as passive recipients of the end product. However, user-driven open-source initiatives in health care are becoming increasingly popular. An example is the growing movement of people with diabetes, who create their own “Do-It-Yourself Artificial Pancreas Systems” (DIYAPS).

Objective
The overall aim of this study is to establish the empirical evidence base for the clinical effectiveness and quality-of-life benefits of DIYAPS and identify the challenges and possible solutions to enable their wider diffusion.

Methods
A research program comprising 5 work packages will examine the outcomes and potential for scaling up DIYAPS solutions. Quantitative and qualitative methodologies will be used to examine clinical and self-reported outcome measures of DIYAPS users. The majority of members of the research team live with type 1 diabetes and are active DIYAPS users, making Outcomes of Patients’ Evidence With Novel, Do-It-Yourself Artificial Pancreas Technology (OPEN) a unique, user-driven research project.

Results
This project has received funding from the European Commission’s Horizon 2020 Research and Innovation Program, under the Marie Skłodowska-Curie Action Research and Innovation Staff Exchange. Researchers with both academic and nonacademic backgrounds have been recruited to formulate research questions, drive the research process, and disseminate ongoing findings back to the DIYAPS community and other stakeholders.

Conclusions
The OPEN project is unique in that it is a truly patient- and user-led research project, which brings together an international, interdisciplinary, and intersectoral research group, comprising health care professionals, technical developers, biomedical and social scientists, the majority of whom are also living with diabetes. Thus, it directly addresses the core research and user needs of the DIYAPS movement. As a new model of cooperation, it will highlight how researchers in academia, industry, and the patient community can create patient-centric innovation and reduce disease burden together.

International Registered Report Identifier (IRRID)
PRR1-10.2196/15368
Decisiones penales en la Constitución mexicana
Authors: García Ramírez Sergio 
Published: October 2019

<p>En la Constitución mexicana no existe un “capítulo penal”. La materia se plantea en diversas series normativas, que conforman el “sistema penal constitucional” sobre el que es preciso proyectar la ideología que inspira la ley suprema, los valores que la presiden y le confieren sentido. En este artículo se busca rastrear dichas disposiciones penales fundamentales. Aquellas series abordan: a) la legalidad penal; b) la sanción jurídica, que fija el “proyecto penal” del Estado; c) el “cuerpo de la justicia” en este ámbito; d) el debido proceso legal: juicio justo; e) el régimen cautelar, que pretende el equilibrio entre los derechos del individuo y la protección de la sociedad, a través de un complejo elenco de medidas; f) los órdenes penales especiales o especializados; y g) instituciones de control y tutela, comunes a todos los sectores, con modalidades o matices en materia penal.</p><div> </div>
Faktor-Faktor yang Berhubungan dengan Partisipasi Ibu dalam Penimbangan Balita
Authors: Hermawan Nur Sefa Arief 
Published: October 2019

ABSTRACT
The coverage of weighing toddlers in West Lampung Regency in 2016 has not met the target. From the 11 of health center in West Lampung Regency, The Srimulyo Suoh health center (Puskesmas) is a health center with underfive weighing coverage because the achievement of underfive weighing coverage has decreased, from 62.8% in 2015 to 52.5% in 2016, this figure is still low means has not met the achievement target of 75%.. The purpose of this study was to determine the relationship between knowledge and attitudes with maternal participation in weighing toddlers in the Working Area of ​​the Puskesmas Srimulyo Suoh in West Lampung 2017. The purpose of this study was to determine the factors related to maternal participation in weighing toddlers in the working area of ​​The Srimulyo Suoh health center in West Lampung in 2017. In this case, the researchers looked at the variable knowledge and attitudes of mothers. This type of research is quantitative, with the cross sectional approach. The population in this study were all mothers who had children under five who were in the Working Area of ​​the Puskesmas Srimulyo Suoh West Lampung amounting to 54 respondents. In this study the sampling technique used uses the total population. The results in the study found that p value for the knowledge variable p value = 0.04 and attitude p value = 0.025 so that p value <0.05, which means there is a relationship between knowledge and attitudes with maternal participation in weighing toddlers in the Puskesmas Srimulyo Suoh West Lampung. Suggestions for mothers of children under five so that they can continue to improve their activity in participating in good posyandu activities by asking health workers about weighing toddlers and using health services as well as possible.
Keywords : Participation, Mother, Weighing Toddlers
Hubungan antara Perilaku Hidup Bersih dan Sehat (PHBS) Tatanan Rumah Tangga dengan Kejadian Diare pada Balita
Authors: Jamil Laila 
Published: October 2019

ABSTRACT
Diarrhea is a public health problem, especially in infants. Diarrhea can be prevented if the community have a good implement Clean and Healthy Behavior (PHBS). This study aims to determine The Relationship Between Clean And Healthy Behavior (PHBS) Of The Household Part With The Incidence Of Childhood Diarrhea. Subjects in this study were the mother In The Working Area Of Puskesmas Mangunjaya Tambun Selatan Bekasi who have children aged 12- 59 months. The research design used is analytic survey research with cross sectional approach, data taken from respondent by using questionnaire. The analysis used for this reseach is univariate, bivariate, and multivariate. The results of univariate analysis in this study where most respondents didnt experience diarrhea occurence in infants in the last three months (62%), PHBS household arrangement (71,3%), have children 25-59 months old (73,1%), have male toddler (50,9%), ≥ 26 years old (80,6%), had recent high education (63,9%), has a family income month < UMR (68,5%), and has 1 toddler (80,6%). The results of bivariate test showed that there is a significant relationship between the behavior of clean and healthly live (PHBS) of the household order with the incidence of diarrhea in infacts In The Working Area Of Puskesmas Mangunjaya Tambun Selatan Bekasi 2018 (Pvalue 0,000). Puskesmas officers must be intensive and continuous in providing health counseling about the factors related to the incidence of chilhood diarrhe, especially Clean And Healthy Behavior (PHBS) Of The Household Part to community In The Working Area Of Puskesmas Mangunjaya Tambun Selatan Bekasi.
Keyword : The Relationship Between Clean And Healthy Behavior, Childhood Diarrhea
Generalizabilty Probability: Importance in Clinical Research
Authors: Santosh Kumar Rada , Sai Kiran S. 
Published: October 2019

International conference on harmonization (ICH) suggested that bridging study is important to extrapolate clinical results. and also us food and drug administration requires Substantial evidences regarding safety. The review explains about different approaches that are necessary for obtaining clinical results, various clinical results were performed between similar patient population within same or different regions. moreover no criteria on the evaluation of similarity of clinical results between regions is given .It is important in regulatory submission of new drug application .Mainly this review explains about how clinical results are reproducible.
Keywords: ICH, Generalizability, probability Reproducibility, clinical trails, bridging study.
GC–MS Analysis of Bioactive Compounds Present in Marketed Herbal Formulation Pykure Capsule
Authors: Firdouse Seema , Begum Humaira Fatima , Alam Parwez 
Published: October 2019

It is more acceptable to believe that natural remedies are safer than synthetic subjects that with fewer side effects. The global market demand was increasing due to fusion of herbs. Standardization parameters and evaluation of herbal formulation is essential in order to assess the quality of drug of therapeutic value. This study was carried out in order to determine the bioactive compounds present in the marketed herbal formulation pykure capsule by using the GC–MS instrument. The extract was prepared by using 20 capsules by removing the capsule shell with ethanol solvent by simple maceration method. Capsule extract was analyzed by using Agilent 6890 GC with 59739N MSD and GC -MS equipped with Elite–I fused with silica capillary column (Cpsil 8cb:30mm×25mm×0.25mm). The result of GC-MS analysis confirmed the presence of 74 compounds.
Keywords: Pykure capsule, Ethanolic extract, GC-MS analysis.
Study of the Association between Hypothyroidism and Non-Alcoholic Fatty Liver Disease
Authors: Uniyal Anoop , Mathur Prashant , Joshi Yogesh 
Published: October 2019

Aim: The aim of the present study was to investigate the association between hypothyroidism and non-alcoholic fatty liver disease (NAFLD).
Methods: In a prospective observational study, the hypothyroidism patients were evaluated for NAFLD using ultrasonography. The participant’s characteristics such as age, gender, thyroid profile, history of diabetes, hypertension, ischemic heart disease (IHD) were recorded using a data gathering form.
Results: A total of 51 participants were included in this study. From 51 participants, 47 (92.18%) individuals were females whereas 4 (7.82%) individuals were males. Out of 51 participants 27 individuals had NAFLD. There was statistically significant difference in FT4 levels with the participants with NAFLD.
Conclusion: Results from this study suggested that low FT4 concentration is associated with increased risk of NAFLD.
Keywords: Hypothyroidism, NAFLD, ultrasonography, FT4.
Ayurvedic Management of Infertility W.S.R. Anovulation: A Case Study
Authors: Pandya Neha , Baraiya Hetal P. 
Published: October 2019

Patient was anxious to conceive after active married life of 5 years. The present case study was done to evaluate the role of Ayurvedic Shodhana therapy i.e. Yogabasti for two consecutive menstrual cycles in the management of anovulation. After completing two courses of Yogabasti, improvement was noticed i.e. Ovulation study (during treatment - anovulatory cycle, After treatment - ovulatory cycle). The line of treatment was followed in this case was to treat the provoked Vata Dosha and vitiated Rasa Dhatu. There were no adverse effects found during the Ayurvedic Panchakarma procedure i.e. Yogabasti.
Keywords: Anovulation, Panchakarma, Shodhana, Yogabasti
Evaluation of Analgesic Activities of 80% Methanol Leaf Extract of Solanum incanum L. (Solanaceae) in Mice
Authors: Abera Binyam , Hailu Abebe Ejigu 
Published: October 2019

Solanum incanum Linnaeus is traditionally used for treatment of pain and other ailments. But there is no scientific evidence on its analgesic activity to-date. Thus the aim of this study was to evaluate the analgesic activities of 80% methanol leaf extract of S.incanum in mice. After extraction of the crude using 80% methanol, S.incanum extract was evaluated for analgesic activity in hot plate test and acetic-acid induced writhing test. Mice were randomly assigned to different groups and treated with 100, 200 and 400 mg/kg doses of the extract and reference control groups (morphine 5mg/kg and Aspirin 150 mg/kg) and negative control were treated with 2% tween 80. In the hot-plate method, all doses of the extract and the standard drug of morphine prolonged the reaction time significantly (p<0.05, or p<0.01 or p<0.001) as compared to negative control throughout the observation period. Prolongation of reaction time produced by 100mg/kg of the extract was lower (p<0.01) compared to morphine, 200mg/kg, and 400mg/kg at 90 and 120 min. However, middle and higher dose exerts comparable result at 30, 60 and 90and 120 min in relation to the standard drug. In addition 80% methanol extract of S.incanum showed a significant protection (p<0.05) against acetic acid induced writhing compared to negative control. The extract produced a significant analgesic activity with 55.6, 38.2 and 44.8% inhibition of number of writhing at 100, 200 and 400 mg/kg dose levels, respectively. In conclusion, this study clearly suggests that 80% methanol leaf extract of S. incanum is endowed with central and peripheral analgesic activity. Hence, the findings collectively uphold the traditional use of the plant for pain treatment.
Keywords: Analgesic, S.incanum , Hot plate, Acetic acid
New regimen for treatment of irritable bowel syndrome with emphasis on Sulpride as the sole maintenance therapy
Authors: El-Reshaid Kamel , Al-Bader Shaikha 
Published: October 2019

The efficiency and safety of Sulpirid (50 mg twice/daily) was assessed in 563 adult patients with 6 groups of patients with irritable bowel syndrome (IBS) who had failed dietary therapy. The groups included; patients without previous treatment (n: 137), patients who had received a muscarinic antagonists (n: 65), an anticholinergic/benzodiazepine combination (n: 187), a tricyclic antidepressants (n: 62), a selective serotonin reuptake inhibitors (SSRIs) (n: 48) and an antiflatulent (n: 64). Patients were assessed for 6 weeks. Sulpirid was effective and safe in safe in relieving the abdominalgia, anxiety, depression and bowel function. The overall success of Sulpride in treatment of IBS was 84%. Most patients who had failed muscarinic antagonists, antiflatulent and tricyclic antidepressants had > 95% improvement with Sulpride. The success was 88% in those who did not receive prior therapy while it was just 77% and 72% in those who had failed SSRIs and anticholinergic/benzodiazepine combination. In treatment-failures, a further 9.8% improvement was achieved with addition of a SSRI (Escitalopram) and an extra 3.4% with subsequent increase in Sulpride dose to 100 mg X 2 limiting failures to only 2.3%. Tolerance of treatment was good and side-effects developed in 11% patients. In conclusion: Sulpride is an effective and safe drug in IBS.
Keywords: Antidepressants, anxiolytics, irritable bowel syndrome, treatment, Sulpride
PHYTOCHEMICAL SCREENING AND ANTIDIABETIC, ANTIHYPERLIPIDEMIC PROPERTIES OF LEAVES OF Filicium decipiens IN STREPTOZOTOCIN INDUCED DIABETIC RATS.
Authors: Akila Elias , Geetha Priya C 
Published: October 2019

The Present study was undertaken with a view to evaluate the Phytochemical & Pharmacological activities of the leaves of Filicium decipiens (Sapindaceae). The shade dried powdered plant material was subjected to successive soxhlet extraction with Petroleum Ether, Chloroform, Ethyl acetate and Ethanol. The various extracts were then subjected to preliminary phytochemical screening which revealed the presence of flavanoids, saponins, tannins, phenols, sugars, lipids, alkaloids & steroids. Selection of active extract for in vivo studies was based on preliminary phytochemical tests and in vitro glucose diffusion inhibition potential and accordingly ethanolic and chloroform extracts were chosen for further studies. Pharmacological screening included evaluation of antidiabetic and hypolipidemic activity of chloroform and ethanolic extracts (200mg/kg b.w) on Streptozotocin induced diabetic rats. The ethanolic extract was found to be more effective and brought about significant antidiabetic & hypolipidemic potential. This was due to the presence of one or more phytoconstituents present in ethanol extract. Thus, the present study validates the traditional claim of the plant and endorses a scientific proof in future.
Release of dipicolinic acid from spores of Geobacillus stearothermophilus
Authors: Reyes Alvin T , Ambita Dave , Batalon Jamie Louise , Aba Berna Lou , Cortes Angelbert , Macabecha Cherray Gabrielle , Montecillo Andrew 
Published: October 2019

The effect of eight pH suspensions (2, 4, 6, 7, 8, 10, 12 and 14) and four heating times (5, 15, 30 and 60 minutes) on the release of dipicolinic acid (DPA) from spores of Geobacillus stearothermophilus was evaluated. The pattern of DPA release from spores of the bacterium exhibited two peaks, one at pH 4 (41.75 ug/mL) and the second at pH 7 (43.25 ug/mL). One-way ANOVA showed that the DPA released at pH 4 and pH 7 was significantly higher as compared to other pH DPA values (p<0.05). Maximum release of the acid from the spores of G. stearothermophilus was achieved after 30 minutes of autoclaving at 121 °C. The maximum level of DPA obtained was 177 ug/mL which was four times higher as compared to the maximum DPA released in the pH experiment. One-way ANOVA showed that the DPA released after 30 minutes autoclaving was significantly higher as compared to DPA released in other heating times (p<0.05). Basing from the result obtained in the study of Rotman and Fields (1969), the variant that was used in this exercise was the smooth type because of the comparable peak of DPA at pH 7 and lower heat resistant with maximum release of DPA after 30 minutes of autoclaving at 121 °C.
Keywords: Dipicolinic acid, Geobacillus stearothermophilus, spores, temperature, pH
Formulation and Evaluation of Liquid Filled Hard Gelatin Capsule of Febuxostat
Authors: Sonar S. P. , Gondkar S.B. , Saudagar R.B. 
Published: October 2019

Liquid filled hard gelatin capsule are well recognized as a solid dosage form for convenient administration of drugs orally in a liquid form. This liquid composition available help the most challenging drug compounds in capsules has increased significantly in recent years. The drugs which have low solubility, poor bioavailability, low melting point, critical stability are the perfect candidate for liquid filling in capsule. The current study presents the formulation aspects, filling and sealing aspects of capsule, evaluation parameters of the liquid filled hard gelatin capsule using Febuxostat as drug, oils (Arachis oil, Coconut oil, Olive oil) as solvents, Glyceryl monostearate as solubilizing agent, Butylated hydroxy toluene as antioxidant, Methyl paraben & Propyl paraben as preservatives. A capsule formed F3 formulation shows maximum drug release and drug content among all the formulations.
Keywords: Liquid filled hard gelatin capsule, Febuxostat, Arachis oil, Coconut oil, Olive oil, Glyceryl monostearate, Butylated hydroxy toluene, Methyl paraben, Propyl paraben.
Formulation, Development and Evaluation of Fast Dissolving Oral Film of a Atenolol Drug and validation by RP-HPLC Method using ICH Q2 guidelines
Authors: KHANDARE BALU S. , Wagh Komal S. 
Published: October 2019

Now a days, fast dissolving dosage forms are gaining popularity, as this dosage form can be administered without water. Rapid dissolving property, avoiding first pass metabolism and majority of the drug is absorbed through buccal/oral mucosa in to systemic circulation. On oral administration of atenolol undergoes first pass metabolism results in reduced bioavailability up to (60%), so the objective of the present study was to formulate and evaluate fast dissolving oral films of atenolol to overcome the limitation of bioavailability and increase patient’s compliance. In recent studies oral films were prepared by solvent casting method using HPMC K15 as a film formers and PEG 400, glycerin as plasticizers and evaluated for mechanical properties, disintegration and in vitro dissolution. Good mechanical properties and in vitro drug release were shown by all formulations. The Comparing to other formulations, the optimized (F5) Formulation (HPMC K15, CCS and PEG 400) Exhibited drug release of 92.12% in 15 minutes which was significantly high. RP-HPLC is simple, fast, precise, sensitive, and reproducible (liquid chromatography) method was developed and validated for the analysis of atenolol drug formulation. Using C-18 HPLC column separation was carried out. This was maintained at ambient temperature. Analysis was carried out by using UV detector at the wavelength 228 nm. The RP-HPLC method was found to be linear over the concentration ranges from 50-100 μg/mL (r2 =0.999). Retention time for atenolol drug formulation was found to be 5.496min. LOQ of method was 5.7308μg/mL and LOD 2.5036μg/mL.
Keywords: Atenolol, Fast dissolving oral film, Bioavailability, Mechanical properties, C18, RP-HPLC, Methanol