bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic Value of Neutrophil to Lymphocyte Ratio and Mean Platelet Volume on Early Onset Neonatal Sepsis on Term Neonate
Authors: Karabulut Birol , Alatas Silem Ozdem 
Published: September 2020

AbstractBy setting out from increased neutrophil count, decreased lymphocyte count, and increased mean platelet volume (MPV), which is a result of the effect of inflammation on blood cells, we aimed to investigate whether neutrophil to lymphocyte ratio (NLP) and MPV can be used as an auxiliary parameter for the diagnosis of early-onset neonatal sepsis (EOS). This study was conducted by analyzing term neonates with EOS and physiological jaundice who were admitted to the neonatal intensive care unit of Izmir Katip Celebi University Ataturk Training and Research Hospital. A total of 63 neonate files were examined to include 30 term neonates with EOS, and 77 neonate files were examined to include 30 term neonates with physiological jaundice as a control group. NLR had an area under the curve (AUC) of 0.891 for prediction of EOS. At a cut-off level of 1.42, NLR had a likelihood ratio (LR) of 5.5, sensitivity of 88%, a specificity of 84%, a positive predictive value (PPV) of 84.6%, and a negative predictive value (NPV) of 87.5%. MPV had an AUC of 0.666 for the prediction of EOS and at a cut-off level of 9.3 fL, MPV had an LR of 1.23, sensitivity of 84%, a specificity of 32%, a PPV of 55.2%, and an NPV of 66.6%. In conclusion, this study provides evidence that NLR and MPV can be used in addition to conventional parameters in the diagnosis of EOS.
Cerebral Arteriovenous Malformations in Pediatric Patients with Hereditary Hemorrhagic Telangiectasia: Re-evaluating Appearance, Bleeding Risk, and Treatment Necessity in a Selective Meta-analysis
Authors: Mueller Oliver , Kasper Ekkehard , Droege Freya , Goericke Sophia , Stein Klaus-Peter , Sure Ulrich 
Published: September 2020

AbstractPediatric patients suffering from cerebral nidal arteriovenous malformations are a unique population due to the rare occurrence of the disease. Diagnosis of hereditary hemorrhagic telangiectasia (HHT) in children is a rare event and mainly restricted to coincidental detection from screening of possibly afflicted family members. In patients with HHT, it is well known that the incidence of cerebral vascular malformations (CVMs) is higher than expected when compared with the nonafflicted population. Even though CVMs comprise a variety of different distinct anatomical and radiographic entities (e.g., capillary telangiectasia, nidal arteriovenous malformation [AVM], cavernous malformation, dural or pial as well as mixed fistula, and vein of Galen malformation), they are mostly summarized and analyzed all in one category due to the low number of individual cases identified in single centers. Nevertheless, the best treatment algorithm will likely vary significantly between different CVMs as does the clinical presentation and the natural course of the CVM. It is therefore the objective of this article to focus on nidal AVMs in pediatric patients suffering from HHT. To this end, we performed a systematic selective literature research to estimate incidence, clinical and radiological appearance, as well as classification according to established grading system, and to evaluate the necessity of treatment of these lesions in light of their respective outcomes. Our line of arguments explains why we recommend to follow these lesions expectantly and suggest to keep pediatric patients under surveillance with sequential scans until they reach adulthood.
Extensive Pelvic Plexiform Neurofibroma Presenting As Clitoromegaly in a 3-Year-Old Female: Presentation and Management with MEK Inhibitor
Authors: Waldner Richelle C. , Rojas-Vasquez Marta , Metcalfe Peter D. , Haqq Andrea M. 
Published: September 2020

AbstractPlexiform neurofibroma (PN) involvement of the external genitalia in patients with neurofibromatosis type I (NF1) is a rare cause of nonhormonal clitoromegaly. We present a 3-year-old female with known NF1 who presented with clitoromegaly. She was identified with an extensive pelvic mass involving the bladder wall, perineum, labia, clitoris, rectum, and sacral foramina. A partial cystectomy was performed, and histopathology was consistent with PN. She has been initiated on a mitogen activated protein kinase enzyme kinase inhibitor, trametinib, which has been effective in achieving partial radiographic response of the bladder mass over 5 months. Additionally, she has experienced clinical response to trematinib with resolution of urinary urgency and frequency since initiating treatment.
A Novel SETBP1 Gene Disruption by a De Novo Balanced Translocation in a Patient with Speech Impairment, Intellectual, and Behavioral Disorder
Authors: Vrkić Boban Ivona , Sekiguchi Futoshi , Lozić Mirela , Miyake Noriko , Matsumoto Naomichi , Lozić Bernarda 
Published: September 2020

AbstractBalanced chromosomal abnormalities (BCAs) can disrupt gene function resulting in disease. To date, BCA disrupting the SET binding protein 1 (SETBP1) gene has not been reported. On the other hand, de novo heterozygous variants in the highly conserved 11-bp region in SETBP1 can result in the Schinzel–Giedion syndrome. This condition is characterized by severe intellectual disability, a characteristic face, and multiple-system anomalies. Further other types of mutations involving SETBP1 are associated with a different phenotype, mental retardation, autosomal dominant 29 (MRD29), which has mild dysmorphic features, developmental delay, and behavioral disorders. Here we report a male patient who has moderate intellectual disability, mild behavioral difficulties, and severe expressive speech impairment resulting from a de novo balanced chromosome translocation, t(12;18)(q22;q12.3). By whole genome sequencing, we determined the breakpoints at the nucleotide level. The 18q12.3 breakpoint was located between exons 2 and 3 of SETBP1. Phenotypic features of our patient are compatible with those with MRD29. This is the first reported BCA disrupting SETBP1.
Treatment Effects of the Herbst Appliance in Class II Malocclusion Patients after the Growth Peak
Authors: Cançado Rodrigo Hermont , Janson Guilherme , Tompson Bryan , Alvares José Carlos de Castro , Valarelli Fabrício Pinelli , Freitas Karina Maria  Salvatore 
Published: September 2020

Abstract
Objective The aim of this study was to evaluate dentoskeletal changes in the treatment of Class II malocclusion with the Herbst Cantilever Bite Jumper (CBJ) appliance, associated with multibracket appliances after the growth peak, at pretreatment.
Materials and Methods  A sample of 37 individuals was divided into two groups: the experimental group comprised 16 patients treated consecutively for a mean period of 2.52 years with the Herbst CBJ appliance associated with multibracket appliances. A total of 21 subjects (10 males and 11 females) with Class II malocclusion and mean age at T1 of 16.08 years were followed for a mean period of 2.12 years composed the control group. Comparisons between the two groups were performed using initial and final lateral cephalograms. Comparisons between experimental and control groups at pretreatment and of the treatment changes were performed by Mann–Whitney or independent t-tests.
Results Experimental group exhibited a significantly greater labial inclination of the mandibular incisors in comparison to the control group. Additionally, significantly greater corrections in overbite, overjet, and molar relationship were observed in the experimental than in the control groups.
Conclusion The effects of the Herbst CBJ appliance, associated with fixed appliances after the growth peak in Class II malocclusion treatment are correction in molar relationship toward a Class I relationship, decrease of the overjet, decrease of the overbite, and mandibular incisors labial inclination.
The Ideal Microsurgery Fellowship: A Survey of Fellows and Fellowship Directors
Authors: Reghunathan Meera , Zaldana-Flynn Michelle , Rose John , Crisera Christopher A. , Reid Chris M. 
Published: September 2020

Abstract
Background Although microsurgery fellowships have existed since the 1980s, there is no established curriculum. Microsurgery fellowships vary greatly in clinical caseload, case diversity, and training resources, and there is no consensus on the appropriate composition of a microsurgery fellowship. This study surveys fellowship directors (FD) and recent microsurgery fellows (MFs), graduates, to describe the ideal microsurgery fellowship program.
Methods A 15-item questionnaire was sent to 38 FDs and 90 recent microsurgery fellowship graduates. This questionnaire addressed program attributes, case volumes and compositions, ideal experiences, and time allocation to different fellowship experiences. Data were analyzed using descriptive statistics, t-tests, and Chi-squared tests.
Results The FD and MF surveys had a response rate of 47 and 49%, respectively. Both MF and FD agreed that exposure to microsurgical breast reconstruction is the most important characteristic of a microsurgery fellowship (p = 0.94). MF ranked replantation and supermicro/lymphatic surgery as the next most important microsurgical cases, while FD ranked the anterolateral thigh (ALT) flap and free fibula flap (p < 0.001). Both agreed that revisional surgery after microsurgical reconstruction is a very valuable fellowship experience (p = 0.679). Both agreed that 1 day of clinic a week is sufficient.
Conclusion Microsurgical training programs vary in quality and resources. The ideal microsurgery fellowship prioritized breast reconstruction, head and neck reconstruction, and lower extremity reconstruction. Although microsurgical technical expertise is important, a fellowship should also train in revisional surgeries and clinical decision making.
Blue Cone Monochromatism: A Case Report with Opsoclonus and Light Exposure
Authors: Llorente-La-Orden Carlos , Burgos-Blasco Bárbara , Domingo-Gordo Blanca , Hernández-García Elena , Gómez-de-Liaño Rosario 
Published: September 2020

AbstractBlue cone monochromatism (BCM) is a rare X-linked congenital vision disorder that is characterized by a cone dysfunction. We present a case of a 3-year-old boy referred to our department with abnormal eye movements since birth, impaired vision, and difficulties in distinguishing colors. A tendency to stare at the sun was noted. Examination revealed severe loss of visual acuity, high myopia, and opsoclonus. A mutation screening of OPN1LW/OPN1MW gene cluster was performed showing a nucleotide substitution encoding a Cys203Arg (C203R) missense mutation. The diagnosis of BCM in this case was clear and the patient harbored the most frequent genetic alteration. Opsoclonus and continued voluntary light exposure are novel features that have not been previously reported in BCM.
The cultural Cold War in the Middle East
Authors: Haddadian-Moghaddam Esmaeil 
Published: September 2020

AbstractWilliam Faulkner is an interesting case for the history of American cultural diplomacy. Although the State Department hailed him as a Cold War warrior, it had difficulty sponsoring his “modernist” novels in a book program that promoted American ideals during the Cold War. In this article I examine how the Franklin Book Programs arranged for some of Faulkner’s novels to be translated into Arabic and Persian by using sources from the Program’s archive and an interview with a former Franklin editor. The analysis is framed by Faulkner’s rise in status from a marginal to a major world writer. I also assess the cultural forces that led to his inclusion in Franklin’s list of publications. The analysis reveals a tension between American idealism and Cold War imperatives, further challenging the propagandist reading of the program and calling for a more nuanced understanding of the dynamics of the cultural Cold War in the region.
The Relationship between Knowledge, Attitudes, and Practices of Community Pharmacists Regarding Persons with Substance use Disorders
Authors: Rao Deepika , Giannetti Vincent , Kamal Khalid M. , Covvey Jordan R. , Tomko John R. 
Published: September 2020

Background Community pharmacists can play a meaningful role in identification and treatment of substance use disorders (SUD). However, inadequate disease knowledge and negative attitudes are known barriers. The relationship between knowledge, attitudes, and practice of pharmacists regarding persons with SUD has not been evaluated comprehensively in the United States. The objective of the study was to assess knowledge of community pharmacists regarding medications for SUD and evaluate their attitudes, levels of stigma, and clinical practices in SUD. Methods A questionnaire was developed to assess practices, knowledge, screening services, and attitudes toward harm reduction strategies and treatment. A standardized measure of stigma was included along with demographics. A cross-sectional electronic survey was conducted in Pennsylvania, Ohio, and West Virginia among a non-probability sample of community pharmacists working for a retail pharmacy chain (n = 910) and a local alumni network ( n = 50). Scores were calculated for each factor and descriptive analyses, mean differences ( t-tests and ANOVA), correlations with demographics and practice characteristics were performed. Linear and ordinal regressions were utilized to predict knowledge, practice, screening, and stigma scores. Results A total of 134 responses (response rate 13.9%) were collected. On average, the pharmacists were 38 years old, had worked for 15 years, primarily full-time with practice locations in suburban settings. Only 53% reported they received SUD education in pharmacy school. Pharmacists received a mean score of 5.5 and 3.5 out of eight and seven on knowledge and practice scales, respectively. Pharmacists overall had slightly stigmatizing and negative attitudes, with higher stigma significantly related to performing lesser services and considering screenings as important. Number of years worked significantly predicted knowledge and screening. Conclusion Relationships between knowledge, attitudes, and practices indicate a need for experiential education that includes psychosocial aspects of care with increased opportunities for practice.
Truth in Fiction, Underdetermination, and the Experience of Actuality
Authors: Bowker Mark 
Published: September 2020

Abstract
It seems true to say that Sherlock Holmes is a detective, despite there being no Sherlock Holmes. When asked to explain this fact, philosophers of language often opt for some version of Lewis’s view that sentences like ‘Sherlock Holmes is a detective’ may be taken as abbreviations for sentences prefixed with ‘In the Sherlock Holmes stories …’. I present two problems for this view. First, I provide reason to deny that these sentences are abbreviations. In short, these sentences have aesthetic properties that we should not expect of abbreviations. Second, I argue that the apparent truth of these sentences would not be explained even if they were abbreviations. An alternative is presented that avoids these problems. Following Walton, talk about fiction is viewed as a game of make-believe; following Lewis, interpretations of fiction are modelled using possible worlds.
Field Evaluation of the Ultrasonic Personal Aerosol Sampler (UPAS) for Respirable Dust Exposure in a Taconite Mine
Authors: Afshar-Mohajer Nima , Foos Rebecca , Ramachandran Gurumurthy , Volckens John 
Published: September 2020

Abstract
Exposure to respirable dust (RD; the mass fraction of inhaled particles that penetrate to the unciliated airways) is a major health concern in a variety of workplaces. While the estimation of personal exposure is an essential step in protecting worker health from aerosol hazards, the traditional method for assessing personal exposure to RD, suggested by the National Institute for Occupational Safety and Health (NIOSH method 0600), requires equipment that is heavy, bulky, noisy, and has the need of frequent calibration. The ultrasonic personal aerosol sampler (UPAS) is a new personal sampling technology designed to address some of these drawbacks associated with traditional sampling methods. In this study, we field tested and evaluated the performance of the UPAS for assessing worker exposure to RD in a taconite mine. Mineworkers (n = 39) from various job categories were recruited to wear both UPAS and NIOSH 0600 samplers on a work vest to estimate time-weighted exposure to RD. A strong linear relationship was observed (NIOSH method 0600 = 1.06 (UPAS) −9.22 µg m–3, r2 of 0.72, and Pearson correlation coefficient of 0.854). None of the workers were exposed to a RD concentration above the Occupational Safety and Health Administration permissible exposure limit (5 mg m–3). A Bland–Altman analysis revealed that 72% of the valid UPAS samples agreed within ±25% of the traditional method mean. The impact of job category on the correlation of the methods was not statistically significant. This work suggests that the UPAS may present a viable alternative for assessing personal exposure to RD in the workplace.
Why Do Friends Have Similar Educational Expectations? Separating Influence and Selection Effects
Authors: Kretschmer David , Roth Tobias 
Published: September 2020

AbstractThe influence of friends in shaping students’ educational expectations has received considerable theoretical and empirical attention in past research. However, few studies have directly tackled the methodological problems associated with estimating such influence effects. In particular, the separation of selection effects—with students selecting friends with similar educational expectations—from influence effects has remained elusive. In this study, we therefore investigate whether friend influence persists once we account for selection effects and other confounding network-related processes. In addition, we quantify the contribution of selection and influence to the similarity of educational expectations among friends. We rely on two-wave longitudinal data on 1,821 German secondary school students in 77 classrooms and multilevel random-coefficients stochastic actor-oriented models for the coevolution of networks and behaviour. Our results demonstrate that both selection and influence contribute to expectation-based similarity and that selection effects are substantial. This shows that without explicitly accounting for selection, estimates of friend influence effects are likely to be biased.
The Evolution of the Mammalian ABCA6-like Genes: Analysis of Phylogenetic, Expression, and Population Genetic Data Reveals Complex Evolutionary Histories
Authors: Breuss Martin W , Mamerto Allen , Renner Tanya , Waters Elizabeth R 
Published: September 2020

Abstract
ABC membrane transporters are a large and complex superfamily of ATP-binding cassette transporters that are present in all domains of life. Both their essential function and complexity are reflected by their retention across large expanses of organismal diversity and by the extensive expansion of individual members and subfamilies during evolutionary history. This expansion has resulted in the diverse ABCA transporter family that has in turn evolved into multiple subfamilies. Here, we focus on the ABCA6-like subfamily of ABCA transporters with the goal of understanding their evolutionary history including potential functional changes in, or loss of, individual members. Our analysis finds that ABCA6-like genes, consisting of ABCA6, 8, 9, and 10, are absent from representatives of both monotremes and marsupials and thus the duplications that generated these families most likely occurred at the base of the Eutherian or placental mammals. We have found evidence of both positive and relaxed selection among the ABCA6-like genes, suggesting dynamic changes in function and the potential of gene redundancy. Analysis of the ABCA10 genes further suggests that this gene has undergone relaxed selection only within the human lineage. These findings are complemented by human population data, where we observe an excess of deactivating homozygous mutations. We describe the complex evolutionary history of this ABCA transporter subfamily and demonstrate through the combination of evolutionary and population genetic analysis that ABCA10 is undergoing pseudogenization within humans.
Absorption of foreign knowledge: the impact of immigrants on firm productivity
Authors: Bitzer Jürgen , Gören Erkan , Kruse-Becher Sanne 
Published: September 2020

Abstract
What role do immigrants play in firms’ ability to absorb and apply foreign knowledge? Based on a matched employer–employee dataset from Danish manufacturing firms over the period 2001–2011, this study examines the impact of foreign knowledge accessible by firms’ immigrant employees on firm-level total factor productivity (TFP). We construct various firm-specific absorbable foreign knowledge measures that link firms’ immigrant employees to the technological knowledge base of their country of origin. The empirical results suggest that firms employing immigrant employees have higher firm-level TFP outcomes and a higher probability of new firm-level patent applications. The average productivity gain associated with the hiring of one immigrant employee is about 1.5% in the year following the firm’s hiring decision. Additional results show that the estimated productivity increase varies with the level of education and the occupational positions of the immigrant employees. The results are robust to the inclusion of a large range of firm-specific controls and various sensitivity checks.
A framework to investigate fishery dynamics and species size and age spatio-temporal distribution patterns based on daily resolution data: a case study using Northeast Atlantic horse mackerel
Authors: Azevedo Manuela , Silva Cristina 
Published: September 2020

AbstractIn this study, we present an innovative framework to obtain essential biological knowledge on exploited populations, based on fine scale spatio-temporal resolution in biological and fishery data. The framework uses species sales notes by commercial size category, the length and age composition of commercial sizes from onshore sampling and the fishing ground and fishing effort from vessel monitoring system records. We apply the framework to horse mackerel (Trachurus trachurus), one of the most important commercially exploited stocks throughout the Northeast Atlantic, using data collected during 2017 in Portuguese waters. We show that high-resolution mapping of the species annual landings by commercial size category and age group can already reveal different distribution patterns by life stage. We further examined, with daily resolution, the variability in the proportion of adult fish by trip, finding differences along the coast and a seasonal pattern indicating that spawning occurred mainly over the slope and adult horse mackerel dominated in the South zone over the year. The framework can be applied to an extended stock area and for several years to investigate migration patterns across areas as well as intra- and inter-annual changes in the species overall distribution. In addition, its application on a trip basis for the species ensemble landed can provide overriding information for the accuracy of mixed fisheries models and management.