bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intravitreal Use of a Bone Marrow Mononuclear Fraction (BMMF) Containing CD34+ Cells in Patients with Stargardt Type Macular Dystrophy
Authors: Cotrim Carina Costa , Vieira Messias André M. , Jorge Rodrigo , Siqueira Rubens Camargo 
Published: December 2020

To assess the therapeutic potential and the safety of intravitreous use of a bone marrow mononuclear fraction (BMMF) containing CD34+ cells in patients with Stargardt type macular dystrophy. The study was conducted on 10 patients with Stargardt dystrophy with worse

eye

visual

acuity
≤
20
/
125

. A bone marrow aspirate was obtained from all patients, and after processing in the cell therapy center (CTC), 0.1 ml of the intravitreous BMMF suspension was injected into the eye with worse visual acuity. A sham injection was performed in the contralateral eye. The patients were evaluated at baseline and one, three, and six months after the injection. All of them were submitted to measurement of best corrected visual acuity (BCVA), microperimetry, multifocal electroretinography (mfERG) and full field electroretinography (ffERG), autofluorescence (AF), and optical coherence tomography (OCT). Fluorescein angiography was also performed before and six months after the injection. All patients completed the six-month period of evaluation. Mean visual acuity of the treated eye was 1.1 logMAR (20/250) before intravitreous (IV) injection, 0.96 logMAR (20/200+2) one month after injection, and 0.92 logMAR (20/160-1) 3 months after injection. In the untreated eye, mean VA was 1.0 logMAR (20/200) at baseline and 0.96 logMAR (20/200+2) and 0.94 logMAR (20/160-2) one and three months after injection, respectively. In the treated group, VA at baseline ranged from best acuity of 20/125-1 to worst acuity of 20/640+2, going through 20/100+2 and 20/400 during the first month. In the untreated group, BCVA ranged from 20/100+2 to 20/400 at baseline and from 20/100 to 20/400 after one month. The results for the treated group differed significantly at all follow-up times, whereas no significant difference was observed in the untreated group. Regarding the mean sensitivity of microperimetry, although there was improvement throughout all months, a significant difference occurred only during the first month. In the untreated eye, there was no significant difference in any analysis. Angiofluoresceinography did not reveal neovessel formation or tumor growth. The remaining exams were used in order to aid the diagnosis. The results indicate that the use of intravitreous BMMF in patients with Stargardt dystrophy is safe and is associated with a discrete improvement of BCVA and microperimetry in the treated eye compared to the untreated one.
Anatomical Predictors of Pacemaker Dependency After Transcatheter Aortic Valve Replacement
Authors: Nai Fovino Luca , Cipriani Alberto , Fabris Tommaso , Massussi Mauro , Scotti Andrea , Lorenzoni Giulia , Guerra Maria Chiara , Cardaioli Francesco , Rodinò Giulio , Matsuda Yuji , Masiero Giulia , Leoni Loira , Zorzi Alessandro , Fraccaro Chiara , Tarantini Giuseppe 
Published: December 2020

Background:
Conduction disturbances after transcatheter aortic valve replacement (TAVR) are often transient. Limited data exist on anatomic factors predisposing to pacemaker dependency after TAVR. We sought to assess the rate and the possible predictors of pacemaker dependency after TAVR.

Methods:
Consecutive patients undergoing pacemaker implantation up to 30 days after TAVR between May 2014 and September 2019 were included. Baseline electrocardiographic, computed tomography, and procedural characteristics were collected, including valve implantation depth and membranous septum length, an anatomic surrogate of the distance between the aortic annulus and the His bundle. Pacemaker dependency at 30 days and 1 year and all-cause mortality during follow-up were evaluated.

Results:

Of 728 TAVR patients, 112 (53.5% men; median age, 81 years) underwent pacemaker implantation after TAVR. Of these, 44.6% (50 of 112) were pacemaker dependent at 30 days and 46.7% (36 of 77) at 1 year. By multivariate analysis, independent predictors of 30-day pacemaker dependency included left ventricular outflow tract calcifications under the left coronary cusp (odds ratio, 5.69 [95% CI, 1.45–22.31];
P
=0.013) and a difference between membranous septum length and implantation depth (ΔMSID) ≥3 mm (odds ratio, 7.58 [95% CI, 2.07–27.78];
P
=0.002). Conversely, membranous septum length and implantation depth alone were not associated with pacemaker dependency (odds ratio, 0.79 [95% CI, 0.60–1.05];
P
=0.11 and odds ratio, 1.11 [95% CI, 0.99–1.24];
P
=0.08). At a median follow-up of 28.1 (11.7–48.6) months, pacemaker-dependent patients did not show a worse survival (
P
=0.26).

Conclusions:
Less than half of the patients undergoing pacemaker implantation after TAVR are pacemaker-dependent at midterm follow-up. ΔMSID ≥3 mm and the presence of left ventricular outflow tract calcifications under the left coronary cusp, but not membranous septum length nor implantation depth alone, are predictive of long-term pacemaker dependency after TAVR, thus influencing device selection and programming.
Do Better Prisons Reduce Recidivism? Evidence from a Prison Construction Program
Authors: Tobón Santiago 
Published: December 2020

Abstract
I study the effects of prison quality on recidivism using individual-level data from Colombia. To estimate causal effects, I leverage the quasi-random assignment of inmates to newer, less crowded, and higher service prisons. For inmates assigned to newer facilities, I find that the probability of returning to prison within one year is 36% lower. Criminal capital, access to rehabilitation programs, and negative prison experiences, which could trigger changes in intrinsic preferences over illegal occupations, seem to be important mechanisms. The program led to substantial welfare gains, even when assuming a low social cost per crime.
Pentecostalism as a Theological Tradition
Authors: Vondey Wolfgang 
Published: December 2020

Abstract
The concern for a theological tradition among Pentecostals responds to pressing questions of the recognition, invention, and rejection of tradition in late modern society and religion. Tradition, to put it succinctly, is a concern not for the past but for the future of Pentecostalism. This essay critically examines the challenges of designating pentecostal theology as a global tradition by asking what theological elements constitute Pentecostalism as a tradition, what are the dominant theological patterns of its reenactment, and how these constructs aid or resist the formation of pentecostal theology in the future. The quest for answers follows the five essential patterns of tradition proposed by Anthony Giddens: collective memory, ritual expression, a formulaic conception of truth, guardians of the tradition, and its normative content. The results form an ideological, historical, and institutional critique of Pentecostalism and its existential challenges as a theological tradition.
Prosperity, Prophecy and the COVID-19 Pandemic
Authors: Ukah Asonzeh 
Published: December 2020

Abstract
One of the intractable problems of Africa is socioeconomic development. It is a “wicked problem” that has defied decades of tinkering and tweaking of economic policies and government interventions. Like many African governments that succeeded oppressive colonial governments, many religious organizations frequently promise their members the help of divine power to deliver development. African Pentecostalism, especially the prosperity variant, has been at the forefront of promising to make its members healthy and wealthy through divine means. How the theology of plenty and healing has practically improved the economic and therapeutic systems of Africa is a question of debate. Some scholars, in line with pentecostal self-representation, claim that Pentecostalism inspires development from below. This essay critiques this self-image of African Pentecostalism in the context of African economic indices and the raging and ravaging coronavirus disease pandemic. The COVID-19 pandemic presents an important challenge but also an opportunity to test the doctrines and claims of pentecostal leaders. In the attempt to cater to leaders’ economic self-interest, pentecostal responses to the pandemic have, however, been uncoordinated and have failed adequately to mobilize resources that serve its members and the larger society in their moment of needs.
Mind and Hand: Early Scientific Instruments from al-Andalus, and ʿAbbas ibn Firnas in the Cordoban Umayyad Court
Authors: Anderson Glaire D. 
Published: December 2020

Abstract
This essay explores the symbiotic relationship between visual culture and the exact sciences that is revealed by the career of ʿAbbas b. Firnas (d. circa 876), as recounted in the Cordoban court chronicle compiled by the historian Ibn Hayyan (d. 1076), and by early scientific instruments from al-Andalus. Ibn Firnas is today remembered as a polymath and early scientist, yet neither historians of art nor of science have fully explored the implications of his reputation among medieval intellectuals as the wellspring of an Andalusi tradition of fine scientific instrumentation. This essay considers the Arabic account of Ibn Firnas as a maker of such objects, alongside early scientific instruments, exploring what these reveal about connections between elite intellectual culture and craft, between science and art making. It argues that considering the objects and texts in tandem reveals that intellectuals, especially those working in the exact sciences, were also “makers” of medieval Islamic visual culture.
Shah ʿAbbas’s Patronage of the Dynastic Shrine at Ardabil
Authors: Melville Charles 
Published: December 2020

Abstract
The aim of this paper is to introduce information provided by Fazli Beg Khuzani Isfahani (d. after 1640) in the third volume of his chronicle, Afżal al-tavārīkh (The Best of Histories), concerning the building program and patronage of Shah ʿAbbas I (r. 1587–1629), emphasizing his activities away from the capital Isfahan. In the account of a single year, Fazli Beg documents Shah ʿAbbas’s patronage of the dynastic shrine at Ardabil, providing details on both the architectural development of the shrine and the endowment (waqf) deed drawn up to support its charitable work. In the course of his account, Fazli Beg also mentions various local officials whose existence is otherwise unknown.
Archaeology and Cultural Policy in Ottoman Tunisia Part I: Muhammad Khaznadar (1865–70)
Authors: Moumni Ridha 
Published: December 2020

Abstract
During the period of the “Great Reforms” (1837–81), the Ottoman province of Tunisia underwent major changes in its political, military, and economic arenas. This was also the case in the field of archaeology, where the history of excavations in Tunisia had been characterized by competition among foreign archaeologists seeking to enrich their national museums as a reflection of European imperialism. This dynamic would soon change thanks to Muhammad Khaznadar, the elder son of the grand vizier Mustafa Khaznadar. Through a unique trajectory that led him to study with the French historian Ernest Desjardin in Paris from 1863 to 1865, Muhammad Khaznadar developed a passion for antiquities that he would later apply by being the first Tunisian to excavate Carthage. The young dignitary rapidly gathered an important collection of antiquities that he displayed at the World’s Fair in Paris and acquired an international reputation as a modern man. Soon, he secured a “monopoly over antiquities,” which prevented the export of archaeological artifacts from Tunisia. Based on unpublished archives, this inquiry focuses on the rise of Muhammad Khaznadar as a collector and his role in the major cultural reforms that led Tunisians to claim the material remains of their pre-Islamic heritage.
Introduction to the Special Issue ‘Enlightenment and Modernity’
Authors: Vartija Devin J. 
Published: December 2020

Abstract
These introductory remarks present a brief overview of the question of the Enlightenment’s relationship to modernity. It charts the emergence of a novel sense of historicity connected to eighteenth-century usage of the term ‘enlightened’ and the belated, late twentieth-century attempts to connect this usage to modernity. The three contributions to this special issue are then introduced and the commonalities and divergences between them are highlighted.
Phenomenology and God after Heidegger
Authors: Littlejohn M.E. , Rumpza Stephanie 
Published: December 2020

Abstract
In this concluding reflection, the editors of this special issue reflect on the significance that Heidegger has had for French philosophy, precisely because of the creative and critical engagement of many of the original thinkers demonstrated above. It is not insignificant that Christian thinkers were drawn to Heidegger, seeing promise in his expansion of philosophical questioning, above all an enrichment of the idea of truth. However it is equally important to recognize that Heidegger’s native Christian roots were stripped of their animating spirit, the question of God and the revelation of the Hebraic scriptures. It is thus notable that the criticisms from this conference originating from the side of faith frequently appeal to the Scriptures as they argue that there are truths which Heidegger himself simply does not seem to see.
Agencification revisited: trends in consolidation of central government administration in Europe
Authors: Sześciło Dawid 
Published: December 2020

Agencification was one of the main pillars of the New Public Management reforms in Europe in the 1980s and 1990s. The strong increase in the number of agencies and the extension of their autonomy (especially with regard to independent regulatory agencies) significantly changed the organizational architecture of governments. However, the review of organizational reforms implemented over the past two decades in European administrative systems demonstrates a trend towards the rationalization and consolidation of the agency landscape. This article provides insight into major forms and patterns of consolidation, including comprehensive, cross-sectoral agency rationalization initiatives and more selective reforms regarding specific policy areas or types of government functions. It also explores the background of the consolidation reforms, confirming that economic pressures affecting governments in the era of austerity played a crucial role in redefining the position of agencies in governments’ organizational set-up. Points for practitioners Agencies remain the main vehicle for policy implementation across Europe but the trend towards de-agencification emerged in the decade of the 2010s, represented by both comprehensive, cross-sectoral initiatives reducing the agency stock, and consolidations in specific policy areas or covering agencies of specific types. De-agencification was triggered by the 2008 global financial crisis that increased the pressure on the reduction of administrative expenditure. To a lesser extent, it was a reaction to the adverse effects of agencification, such as coordination and steering problems, or the ambiguous impact of agencification on the efficiency of the public administration.
Benefits of Movement-Integrated Learning Activities in Statistics and Research Methods Courses
Authors: Rhoads Michael C. , Kirkland Rena A. , Baker Crystal A. , Yeats Jeremy T. , Grevstad Nels 
Published: December 2020

Background: College students majoring in psychology often report low interest and engagement in statistics and research methods courses. Objective: The purpose of the current study was to examine potential benefits of integrating movement with learning activities in Introduction to Statistics and Research Methods courses at the college level. Method: A quasi-experimental design examined movement-based learning activities compared to traditional learning activities during class periods. Students’ perceptions of the activities were assessed using an experience sampling method. Result: Hierarchical linear models revealed that students rated the movement-integrated activities higher compared to control activities for the following subscales: physical, affect, enjoyment, concentration, and social states. Conclusion: College students may benefit from integration of the movement learning activities into statistics and research methods classes. Teaching Implications: Movement-integrated learning activities offer the potential to increase physical activity, increase positive affect, enhance concentration, and provide opportunities to socialize with classmates. We offer specific techniques for incorporating movement into the college classroom.
Impact of the COVID-19 Pandemic on Patients With Idiopathic Subglottic Stenosis
Authors: Anderson Catherine , Sandhu Guri , Al Yaghchi Chadwan 
Published: December 2020

Objectives: To determine the number of patients with idiopathic subglottic stenosis (iSGS) who have contracted coronavirus disease 2019 (COVID-19), the impact of the pandemic on patients’ attitudes on seeking help and attending hospitals, as well as the delays in the offer of treatment from the local health care systems. Methods: A 29-question survey was distributed to an international mailing list of patients with subglottic stenosis to assess the patient experience during the COVID-19 pandemic. Results: A total of 543 patients with iSGS participated. Fewer than 1 in 10 patients with iSGS have experienced COVID-19 symptoms, which were predominantly mild to moderate, with only 2 hospitalizations. Most patients with iSGS (80.0%) have not been advised they are high risk for COVID-19, despite 36.5% of patients with iSGS being obese (body mass index of 30+). Delays to surgeries and in-office procedures have impacted 40.1% of patients currently receiving treatment, with 38.8% of patients increasingly struggling to breathe as a result. Anxiety and stress are increasing among patients, with 3 in 4 (75.2%) reporting they are anxious about travelling by public transport, contracting the virus in hospital and infecting loved ones (69.0% and 71.9%, respectively). Of greater concern is that 23.1% with increasing dyspnea state they are staying away from hospital despite their deteriorating health. Conclusions: The COVID-19 pandemic has had an impact on the physical and psychological health of patients with iSGS. Surgeons managing cases of laryngotracheal stenosis need to offer appropriate support and communication to these high risk patients. During the pandemic, this should include self-isolation if they are dyspneic or on treatments that may have reduced their immunity. In addition, they should offer safe clinical pathways to airway assessment and treatments, if they become necessary. To minimize unnecessary travel, much of the clinical monitoring can be carried out remotely, using telephone or video-based consultations, in conjunction with local health professionals.
Association of mammography and ultrasound features with MammaPrint in patients with estrogen receptor-positive, HER2-negative, node-positive invasive breast cancer
Authors: Choi Woo Jung , Sim Hayan , Kim Hee Jeong , Cha Joo Hee , Shin Hee Jung , Chae Eun Young , Kim Hak Hee 
Published: December 2020

Background MammaPrint is a 70-gene signature microarray assay that predicts the likelihood of recurrence of breast cancer and chemotherapeutic benefits. Purpose To investigate the association between mammography and ultrasound (US) features and MammaPrint results in patients with estrogen receptor (ER)-positive, HER2-negative, node-positive invasive breast cancer, and to identify the predictive factors for high risk of recurrence. Material and Methods This retrospective study included 251 patients with ER-positive, HER2-negative, 1–3 node-positive invasive breast cancer. Mammography and US findings were reviewed according to the BI-RADS criteria. The association between MammaPrint results and the clinicopathological and imaging features was evaluated. Logistic regression analysis was performed to identify independent predictors for high risk of recurrence. Results Of the patients, 143 (57.0%) and 108 (43.0%) had low and high risks for recurrence on MammaPrint, respectively. Young age (odds ratio [OR] 1.08; 95% confidence interval (CI) 1.04–1.12; P<0.001), posterior enhancement on US (OR 2.45; 95% CI 1.16–5.20; P = 0.019), absence of posterior shadowing on US (OR 3.19; 95% CI 1.17–8.62; P = 0.023), high histologic grade (OR 113.36; 95% CI 6.79–1893.53; P = 0.001), and high Ki-67 level (OR 4.90; 95% CI 2.62–9.17; P<0.001) were independently associated with high risk of recurrence on multivariate logistic regression analysis. Conclusion Posterior features in US may predict a high risk of recurrence in patients with ER-positive, HER2-negative, node-positive invasive breast cancer, which may be useful in enhancing the diagnostic value of MammaPrint and aid in the decision-making process regarding treatment.
Evaluating a Pharmacist-Led Intervention on Cardiovascular- and Diabetes-Related Quality Measures in a Primary Care-Based Accountable Care Organization
Authors: Joseph Tina , Hale Genevieve , Moreau Cynthia , Rosario Elaina D. , Logan Nichelle , Perez Alexandra 
Published: December 2020

Background: The Centers for Medicare and Medicaid Services (CMS) publishes quality measures to gauge performance in Accountable Care Organizations (ACOs). ACO-27 (Diabetes Mellitus: Hemoglobin A1c Poor Control) and ACO-41 (Diabetes: Eye Exam), are 2 components for the Diabetes Composite measure. ACO-42 focuses on Statin Therapy for the Prevention and Treatment of Cardiovascular (CV) Disease. There are limited studies regarding the pharmacist role in CV and Diabetes Management in the ACO primary care setting. Objective: To evaluate the impact of pharmacist-led interventions on CV- and diabetes-related CMS quality measures within a primary care-based ACO. Methods: This retrospective pre-post intervention study included 3 primary care-based ACO offices. Patients who met eligibility criteria for CMS quality measures ACO-27, -41 and -42 were included. Pharmacist interventions occurred in December 2018. The study co-primary outcomes were the percentage of patient meeting ACO-27/-41 (composite diabetes-related) and -42 (statin-related) CMS quality measures in the pre-intervention compared to the post-intervention phases. Results: Of 105 patients meeting study inclusion criteria, 77.1% were on statin therapy prior to intervention. After pharmacist intervention, the prevalence of patients on statin therapy increased to 80.0% (p = 0.083). All patients had a HbA1c less than 9% pre-intervention. Sixty-one (58.1%) patients had a documented dilated eye exam prior to intervention. Post-intervention, the prevalence of exams increased to 73.3% (p < 0.0005). Conclusions: Pharmacists can assist primary care providers in the ACO setting meet CV- and diabetes-related CMS quality measures, demonstrating the value of the pharmacist in value-based health care settings.