bluuebunny/crossref_metadata_2025_split huggingface dataset:
Teatro Inverso’s Rosaura: Recasting La vida es sueño through Storytelling
Authors: Nieto-Cuebas Glenda Y. , Cowling Erin Alice 
Published: April 2020

Abstract
In a world where, paradoxically, increased communication via social networks has caused a rise in physical isolation, stories bring people back together. The theater, however, still allows people to partake in a shared experience. To this end Teatro Inverso has created a theory of Bodily Poetics: the understanding of how the actors’ bodies create the space onstage in connection with the poetry of the words and their actions. The theory was used to create an adaptation of La vida es sueño by Calderón de la Barca, Rosaura, which focuses on the female characters and their connections to each other, the action of the play, and their raw emotions. This article discusses the different ways in which storytelling is being used by Teatro Inverso to create adaptations that speak to their modern audiences.
The Historical and Its Discontents: Nietzsche and Benjamin Against “Historicism”
Authors: Wu Yi 
Published: April 2020

ABSTRACT
Representations of historicism as the loss of meaning in history and critiques of historicism as the critique of such a loss had been pervasive from the late nineteenth century until World War II. Among historicism’s most powerful and representative critics were the young Friedrich Nietzsche and Walter Benjamin in his Parisian exile. This essay seeks to trace from Nietzsche to Benjamin an unbroken yet growing line of critique of historicism—as the “sickness of time” from which modernity both suffers and has been trying to recover. Two attempts at such a recovery will be examined and juxtaposed: Nietzsche’s “On the Uses and Disadvantages of History for Life” and Benjamin’s “Theses on the Philosophy of History.” By thus situating both historicism and its critiques within the desires and anxieties of modernity, this essay tries to delineate and to understand the peculiarly modernist shapes assumed by the historical and its discontents.
Effectiveness of Otago Exercise on Health Status and Risk of Fall Among Elderly with Chronic Illness
Authors: Kiik Stefanus Mendes , Vanchapo Antonius Rino , Elfrida Maria Fitrya , Nuwa Muhammad Saleh , Sakinah Siti 
Published: April 2020

Falls are a serious consequence of declining physical function. Otago exercise is a strength and balance training program designed to prevent falls and enhance health status among the elderly. This study aimed to investigate the effect of a 12-week Otago exercise intended to reduce the risk of falls and health status among the elderly with chronic illness in the social elderly institution. This quasi-experimental study employed a pre- and post-test design using a control group. The study involved an intervention group (21 respondents) and a control group (21 respondents). The sample used in this study were elderly living in a social elderly institution. The sample was selected using simple random sampling. The data were analyzed using Mann–Whitney test, independent t-test, and Chi-square test. Otago exercise significantly reduced the respondents’ risk of falling and enhanced their health status. Significant differences were observed between the two groups in terms of the risk of fall (p= 0.041) and health status (p= 0.011). Otago exercise significantly improves the health status and reduces the risk of falling among elderly with chronic illness. The exercise can be recommended for older adults with chronic illness in social elderly institutions and communities. Abstrak Efektivitas Latihan Otago terhadap Status Kesehatan dan Risiko Jatuh pada Lansia dengan Penyakit Kronik. Jatuh adalah konsekuensi serius dari penurunan fungsi fisik. Latihan Otago adalah program latihan kekuatan dan keseimbangan yang didesain untuk mencegah jatuh dan meningkatkan status kesehatan pada lansia. Penelitian ini bertujuan untuk menginvestigasi efek 12 minggu latihan Otago untuk menurunkan risiko jatuh dan meningkatkan status kesehatan pada lansia dengan penyakit kronik di Panti Sosial lansia. Penelitian Quasi-eksperimental ini menggunakan pre-post dengan kelompok kontrol. Kelompok intervensi dan kontrol masing-masing terdiri dari 21 responden. Sampel dalam penelitian ini adalah lansia yang tinggal di UPT Kesejahteraan Sosial Lanjut Usia Budi Agung Kupang. Teknik sampling yang digunakan adalah simpel random sampling. Data dianalisis menggunakan Mann-Whitney test, Independent t-test dan Chi-square test. Latihan Otago secara signifikan menurunkan risiko jatuh dan meningkatkan status kesehatan. Ada perbedaan signifikan antara kedua kelompok dalam hal risiko jatuh (p= .041) dan status kesehatan (p= 0.011). Latihan Otago secara signifikan menurunkan risiko jatuh dan meningkatkan status kesehatan pada lansia dengan penyakit kronik. Kata Kunci: lansia, latihan Otago, penyakit kronik, risiko jatuh, status kesehatan
The interaction between ubiquitin and yeast polymerase η C terminus does not require the UBZ domain
Authors: Duong Phuong Thi Mai , Bui Anh Thi Ngoc , Kim Seong‐Ok , Park Hee‐Sung , Seo Yeon‐Soo , Choi Byong‐Seok 
Published: April 2020

Polymerase η (Polη) is one of the Y‐family polymerases that is recruited by monoubiquitinated proliferating cell nuclear antigen (Ub‐PCNA) to DNA damage sites during translesion synthesis (TLS). This interaction is mediated by an ubiquitin‐binding zinc‐finger (UBZ) domain and a PCNA‐interacting protein (PIP) box in Polη, which binds to ubiquitin and PCNA, respectively. Here, we show that without the UBZ domain, the PIP box of yeast Polη has a novel binding function with ubiquitin. Furthermore, the UBZ domain and the PIP box share the same binding surfaces for ubiquitin. The interaction with ubiquitin via the PIP box stabilizes the Ub‐PCNA/Polη complex. Moreover, the PIP residues I624 and L625 contribute to Polη function in TLS in vivo.
Stimuli‐Responsive MXene‐Based Actuators
Authors: Nguyen Van Hiep , Tabassian Rassoul , Oh Saewoong , Nam Sanghee , Mahato Manmatha , Thangasamy Pitchai , Rajabi‐Abhari Araz , Hwang Won‐Jun , Taseer Ashhad Kamal , Oh Il‐Kwon 
Published: April 2020

AbstractMXenes, a member of 2D inorganic compounds that contain few‐atom‐thick layers of transition metal carbides, nitrides, and polar surface functional groups, are extraordinary materials for many applications including stimuli‐responsive actuators. Here, an extensive review on MXene‐based actuators in comparison with other 2D materials‐based actuators is reported, highlighting the main differences in view of chemical structure, mechanical properties, and electrical functionalities. First, since MXenes are newcomers in the field of actuators, their properties are explained including cation and ionic liquid intercalation, high capacitance, good electrical and thermal conductivity, excellent electromagnetic wave absorption, hydrophilicity, and outstanding dispersion in many polar solvents. Second, electro‐ionic, electrochemical, electrothermal, photothermal, and humidity‐responsive MXene‐based actuators are comprehensively addressed with detailed actuation mechanisms, focusing on electro‐ionic soft actuators. Third, several applications of those actuators are summarized with an emphasis on soft robotics and future directions of MXene‐based actuators are suggested.
Ionic‐Association‐Assisted Viscoelastic Nylon Electrolytes Enable Synchronously Coupled Interface for Solid Batteries
Authors: Zhao Zhiming , Li Fan , Zhao Jingwen , Ding Guoliang , Wang Jinzhi , Du Xiaofan , Zhou Qian , Hou Guangjin , Cui Guanglei 
Published: April 2020

AbstractElectrolyte/electrode heterointerfaces activated by unhindered charge transfer play an important role in solid‐state and flexible batteries. However, continuous electrochemical cycling and mechanical deformations cause structural dislocation and unwanted reactions. An important challenge is to ensure enduring accurate contact between the battery components. The customization of a highly viscoelastic polyamide (PA, nylon)‐based solid electrolyte to address this key issue is presented. The approach involves the use of concentrated aqueous solutions of bis(trifluoromethane)sulfonimide lithium (LiTFSI) to structurally “unzip” and relink pristine hydrogen‐bonded PA chains by bridged cation–anion association. This elaborately tailored crosslinking technique confers upon the resultant electrolyte a combination of the preferred mechanical characteristics including high viscoelasticity and reversible stretchability, together with outstanding electrochemical performance represented by high ion conductivity (2.7 × 10−4 S cm−1) and high anodic stability (>3 V vs Zn/Zn2+). Flexible batteries with a well‐integrated configuration in which synchronous electrolyte/electrode movement guarantees intimate and compatible interfaces even during extreme deformations and electrochemical stimulations, are further demonstrated. These results reveal a promising opportunity to overcome the bottleneck caused by interfacial defects for next‐generation solid batteries by reconstituting the structure of classical polymers and developing functional electrolytes.
Porous Pd‐PdO Nanotubes for Methanol Electrooxidation
Authors: Wang Tian‐Jiao , Li Fu‐Min , Huang Hao , Yin Shi‐Wei , Chen Pei , Jin Pu‐Jun , Chen Yu 
Published: April 2020

AbstractPalladium (Pd) nanostructures are highly active non‐platinum anodic electrocatalysts in alkaline direct methanol fuel cells (ADMFCs) and their electrocatalytic performance relies highly on their morphology and composition. Herein, a facile high‐temperature pyrolysis method to synthesize high‐quality Pd‐palladium oxide (PdO) porous nanotubes (PNTs) by using Pd(II)‐dimethylglyoxime complex (Pd(II)‐DMG) nanorods as a self‐template is reported. The chemical component of pyrolysis products highly correlates with pyrolysis temperature. The electrochemical measurements and density functional theory calculations show the existence of PdO enhances the electroactivity of metallic Pd for both methanol oxidation reaction (MOR) and carbon monoxide oxidation reaction in alkaline media. Benefiting from its one‐dimensionally porous architecture and evident synergistic effect between PdO and Pd (e.g., electronic effect and bifunctional mechanism), Pd‐PdO PNTs achieve a 3.7‐fold mass activity enhancement and improved durability for MOR compared to commercial Pd nanocrystals. Considering the simple synthesis, excellent activity, and long‐term stability, Pd‐PdO PNTs may be highly promising anodic electrocatalysts in ADMFCs.
MXene Printing and Patterned Coating for Device Applications
Authors: Zhang Yi‐Zhou , Wang Yang , Jiang Qiu , El‐Demellawi Jehad K. , Kim Hyunho , Alshareef Husam N. 
Published: April 2020

AbstractAs a thriving member of the 2D nanomaterials family, MXenes, i.e., transition metal carbides, nitrides, and carbonitrides, exhibit outstanding electrochemical, electronic, optical, and mechanical properties. They have been exploited in many applications including energy storage, electronics, optoelectronics, biomedicine, sensors, and catalysis. Compared to other 2D materials, MXenes possess a unique set of properties such as high metallic conductivity, excellent dispersion quality, negative surface charge, and hydrophilicity, making them particularly suitable as inks for printing applications. Printing and pre/post‐patterned coating methods represent a whole range of simple, economically efficient, versatile, and eco‐friendly manufacturing techniques for devices based on MXenes. Moreover, printing can allow for complex 3D architectures and multifunctionality that are highly required in various applications. By means of printing and patterned coating, the performance and application range of MXenes can be dramatically increased through careful patterning in three dimensions; thus, printing/coating is not only a device fabrication tool but also an enabling tool for new applications as well as for industrialization.
A Scalable Interfacial Engineering Strategy for a Finely Tunable, Homogeneous MoS2/rGO‐Based HER Catalytic Structure
Authors: Xu Linan , Zhang Yihe , Feng Lili , Li Xin , An Qi 
Published: April 2020

AbstractThe electronic structures and catalytic efficacies of molybdenum disulfide (MoS2)‐based catalysts are sensitive to embedding environment. In order to develop a finely tunable strategy, a “layer‐by‐layer and Nafion capping” strategy for the scalable preparation of interfacial (MoS2)‐based catalytic structures is developed. The study shows that the assembly partner influences the electronic structures of the Zn&N co‐doped (MoS2) (Zn‐N‐(MoS2)) catalysts. Poly(allylamine hydrochloride) (PAH) decreases the catalytic efficacy, whereas when PAH‐rGO (rGO [reduced graphene oxide]) is the assembly partner, effective interfacial catalysts are prepared. The superior catalytic efficacy of (PAH‐rGO/Zn‐N‐(MoS2))n can be attributed to the fact that rGO effectively activates the basal plane S2− as the active sites. The catalytic efficacy of the multilayers at 16 assembly cycles due to a balance between the number of active sites and low resistance. After capping with Nafion layer, the interfacial catalysts exhibit high stability. Compared with the widely used drop‐casting methods, the layer‐by‐layer strategy possesses unique benefits, including fine‐tune the structures, free choice of the partner, and planar homogeneity. It is expected that this layer‐by‐layer catalyst immobilization strategy will benefit fundamental understandings regarding the finely controlled scalable interfacial immobilization of catalysts with superior efficacy, and assist in promoting the practical utilization of various catalysts.
Nanopaper‐Based Organic Inkjet‐Printed Diodes
Authors: Conti Silvia , Martínez‐Domingo Carme , Lay Makara , Terés Lluís , Vilaseca Fabiola , Ramon Eloi 
Published: April 2020

AbstractThe rise of internet of things (IoTs) applications has led to the development of a new generation of light‐weight, flexible, and cost‐effective electronics. These devices and sensors have to be simultaneously easily replaceable and disposable while being environmentally sustainable. Thus, the introduction of new functionalized materials with mechanical flexibility that can be processed using large‐area and facile fabrication methods (as, for example, printing technologies) has become a matter of great interest in the scientific community. In this context, cellulose nanofibers (CNFs) are renewable, affordable, robust, and nontoxic materials that are rapidly emerging as components for eco‐friendly electronics. Their combination with conductive polymers (CPs) to obtain conductive nanopapers (CNPs) allows moving their functionality from just substrates to active components of the device. In this work, a route for the inkjet‐printing of organic diodes is outlined. The proposed strategy is based on the use of CNPs as both substrates and bottom electrodes onto which insulator and organic semiconducting layers are deposited to fabricate novel diode structures. Remarkable rectification ratios of up to 1.2 × 103 at |3 V| and a current density up to 5.1 µA cm−2 are achieved. As a proof‐of‐concept of the potentiality of the approach for versatile, low‐temperature, and disposable sensing applications, an NO2 gas sensor is presented.
Bench‐Stable Manganese NHC Complexes for the Selective Reduction of Esters to Alcohols with Silanes
Authors: Sousa Sara C. A. , Realista Sara , Royo Beatriz 
Published: April 2020

AbstractSelective reduction of esters to alcohols was accomplished through Mn(I)‐mediated hydrosilylation reaction. The manganese tricarbonyl complex [Mn(bis‐NHC)(CO)3Br] resulted an active pre‐catalyst for the reduction of a variety of esters using phenylsilane and the cheap and readily available polymethylhydrosiloxane. An in situ examination of the catalytic reaction using 55Mn NMR spectroscopy allowed us to detect the formation of Mn(I) intermediate active species.magnified image
Copper‐Catalyzed Enantioselective Cyano(Fluoro)Alkylation of Alkenes
Authors: Israr Muhammad , Xiong Haigen , Li Yajun , Bao Hongli 
Published: April 2020

AbstractA copper‐catalyzed asymmetric cyano(fluoro)alkylation reaction of alkenes is reported. A range of chiral fluoroalkyl cyanides were obtained in high yields and excellent enantiomeric excess from readily available chemicals. The method uses fluoroalkyl iodides as the fluoroalkyl source and employs mild conditions. The peroxide LPO plays a significant role in promotion of this radical asymmetric reaction.magnified image
Chronic myeloid leukemia: 2020 update on diagnosis, therapy and monitoring
Authors: Jabbour Elias , Kantarjian Hagop 
Published: April 2020

AbstractDisease overviewChronic myeloid leukemia (CML) is a myeloproliferative neoplasm with an incidence of 1‐2 cases per 100 000 adults. It accounts for approximately 15% of newly diagnosed cases of leukemia in adults.DiagnosisCML is characterized by a balanced genetic translocation, t(9;22)(q34;q11.2), involving a fusion of the Abelson gene (ABL1) from chromosome 9q34 with the breakpoint cluster region (BCR) gene on chromosome 22q11.2. This rearrangement is known as the Philadelphia chromosome. The molecular consequence of this translocation is the generation of a BCR‐ABL1 fusion oncogene, which in turn translates into a BCR‐ABL oncoprotein.Frontline therapyFour tyrosine kinase inhibitors (TKIs), imatinib, nilotinib, dasatinib, and bosutinib are approved by the United States Food and Drug Administration for first‐line treatment of newly diagnosed CML in chronic phase (CML‐CP). Clinical trials with second generation TKIs reported significantly deeper and faster responses, but they had no impact on survival prolongation, likely because of the existence of highly effective salvage therapies for patients who have a cytogenetic relapse with frontline TKI.Salvage TherapyFor CML post failure on frontline therapy, second‐line options include second and third generation TKIs. Although potent and selective, these exhibit unique pharmacological profiles and response patterns relative to different patient and disease characteristics, such as patientsʼ comorbidities, disease stage, and BCR‐ABL1 mutational status. Patients who develop the T315I “gatekeeper” mutation display resistance to all currently available TKIs except ponatinib. Allogeneic stem cell transplantation remains an important therapeutic option for patients with CML‐CP who have failed at least 2 TKIs, and for all patients in advanced phase disease. Even among older patients who have a cytogenetic relapse post failure on all TKIs, they can maintain long‐term survival if they continue on a daily most effective/less toxic TKI, with or without the addition of non‐TKI anti‐CML agents (hydroxyurea, omacetaxine, azacitidine, decitabine, cytarabine, busulfan, others).
Predicting 19F NMR Chemical Shifts: A Combined Computational and Experimental Study of a Trypanosomal Oxidoreductase–Inhibitor Complex
Authors: Dietschreit Johannes C. B. , Wagner Annika , Le T. Anh , Klein Philipp , Schindelin Hermann , Opatz Till , Engels Bernd , Hellmich Ute A. , Ochsenfeld Christian 
Published: April 2020

AbstractThe absence of fluorine from most biomolecules renders it an excellent probe for NMR spectroscopy to monitor inhibitor–protein interactions. However, predicting the binding mode of a fluorinated ligand from a chemical shift (or vice versa) has been challenging due to the high electron density of the fluorine atom. Nonetheless, reliable 19F chemical‐shift predictions to deduce ligand‐binding modes hold great potential for in silico drug design. Herein, we present a systematic QM/MM study to predict the 19F NMR chemical shifts of a covalently bound fluorinated inhibitor to the essential oxidoreductase tryparedoxin (Tpx) from African trypanosomes, the causative agent of African sleeping sickness. We include many protein–inhibitor conformations as well as monomeric and dimeric inhibitor–protein complexes, thus rendering it the largest computational study on chemical shifts of 19F nuclei in a biological context to date. Our predicted shifts agree well with those obtained experimentally and pave the way for future work in this area.
Nanoformulated Single‐Stranded RNA‐Based Adjuvant with a Coordinative Amphiphile as an Effective Stabilizer: Inducing Humoral Immune Response by Activation of Antigen‐Presenting Cells
Authors: Park Hyo‐Jung , Bang Eun‐Kyoung , Hong Jung Joo , Lee Sang‐Myeong , Ko Hae Li , Kwak Hye Won , Park Hyelim , Kang Kyung Won , Kim Rhoon‐Ho , Ryu Seung Rok , Kim Green , Oh Hanseul , Kim Hye‐Jung , Lee Kyuri , Kim Minjeong , Kim Soo Young , Kim Jae‐Ouk , El‐Baz Karim , Lee Hyukjin , Song Manki , Jeong Dae Gwin , Keum Gyochang , Nam Jae‐Hwan 
Published: April 2020

AbstractAs agonists of TLR7/8, single‐stranded RNAs (ssRNAs) are safe and promising adjuvants that do not cause off‐target effects or innate immune overactivation. However, low stability prevents them from mounting sufficient immune responses. This study evaluates the adjuvant effects of ssRNA derived from the cricket paralysis virus intergenic region internal ribosome entry site, formulated as nanoparticles with a coordinative amphiphile, containing a zinc/dipicolylamine complex moiety as a coordinative phosphate binder, as a stabilizer for RNA‐based adjuvants. The nanoformulated ssRNA adjuvant was resistant to enzymatic degradation in vitro and in vivo, and that with a coordinative amphiphile bearing an oleyl group (CA‐O) was approximately 100 nm, promoted effective recognition, and improved activation of antigen‐presenting cells, leading to better induction of neutralizing antibodies following single immunization. Hence, CA‐O may increase the efficacy of ssRNA‐based adjuvants, proving useful to meet the urgent need for vaccines during pathogen outbreaks.
Fluoro‐Substituted Methyllithium Chemistry: External Quenching Method Using Flow Microreactors
Authors: Colella Marco , Tota Arianna , Takahashi Yusuke , Higuma Ryosuke , Ishikawa Susumu , Degennaro Leonardo , Luisi Renzo , Nagaki Aiichiro 
Published: April 2020

AbstractThe external quenching method based on flow microreactors allows the generation and use of short‐lived fluoro‐substituted methyllithium reagents, such as fluoromethyllithium, fluoroiodomethyllithium, and fluoroiodostannylmethyllithium. Highly chemoselective reactions have been developed, opening new opportunities in the synthesis of fluorinated molecules using fluorinated organometallics.
Taming the Reactivity of Phosphiranium Salts: Site‐Selective C‐Centered Ring Opening for Direct Synthesis of Phosphinoethylamines
Authors: Gasnot Julien , Botella Clément , Comesse Sébastien , Lakhdar Sami , Alayrac Carole , Gaumont Annie‐Claude , Dalla Vincent , Taillier Catherine 
Published: April 2020

AbstractAdvances in the field of phosphorus chemistry are documented, by revealing the synthetic utility of previously underutilized quaternary phosphiranium salts (QPrS) as three‐chain‐atom electrophilic building blocks. Notably, control of their challenging C‐centered electrophilicity is disclosed with an expedient synthesis of tertiary β‐anilino phosphines as a proof‐of‐concept.