bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrogen sulfide protects from cisplatin-induced acute kidney injury via attenuating inflammation activated by necroptosis in canine
Authors: Wang Shuang , Xu Enshuang , Ge Ruidong , Jia Haotian , Fan Yuying , Hu Mengxin , Jin Shengzi , Guan Tongxu , Ren XiaoLi , Liu Yun 
Published: August 2020

Abstract
Background Cisplatin, as an effective anti-cancer drug, has significant effects on a variety of solid tumors such as ovarian cancer and malignant lymphoma. However, cisplatin has strong nephrotoxicity, which greatly limits its clinical application. Unfortunately, the way to validly inhibit cisplatin-induced kidney damage remain poor understood currently. Hydrogen sulfide (H2S) was considered to be the third new gas signal molecules, involved in various physiological functions of the body. This present study was designed to investigate the effect of H2S on cisplatin-induced acute kidney injury (AKI) and the involved mechanisms in canine.Results Cisplatin-inject canine developed severe AKI symptom as indicated by renal dysfunction and pathological changes. Whereas H2S attenuated the serum creatinine (Scr), blood urea nitrogen (Bun) level and renal tubular damage. Cisplatin induced necroptosis and regulated the corresponding protein expression of RIPK1, RIPK3, PARP1, and then activated inflammatory factors expression such as TNF-α, NF-κB, IL-1β in canine kidney tissues. Cisplatin also triggered oxidative stress and affected energy metabolism. However, H2S significantly improved necroptosis and inflammation, manifested by increasing Cas8 activity and the expression of anti-inflammatory factors such as IL-4, IL-10 and IFN-γ. At the same time, the antioxidant capacity and energy metabolism levels of canine kidney were notably improved.Conclusion Collectively, our results suggest that H2S protect kidney from cisplatin-induced AKI via mitigating necroptosis and inflammation. Besides, H2S improved the level of energy metabolism and displayed a potency in cisplatin-induced oxidative stress. These provided a new idea for reducing cisplatin nephrotoxicity.
A new candidate vaccine for human brucellosis based on influenza viral vectors: development of immunization schedule in guinea pig model
Authors: Bugybayeva Dina , Kydyrbayev Zhailaubay , Zinina Nadezhda , Assanzhanova Nurika , Yespembetov Bolat , Kozhamkulov Yerken , Zakarya Kunsulu , Tabynov Kaissar , Ryskeldinova Sholpan 
Published: August 2020

Abstract
Background: A new candidate vector vaccine against human brucellosis based on recombinant influenza viral vectors (rIVV) subtypes H5N1 expressing Brucella Omp16, L7/L12, Omp19 or Cu-Zn SOD proteins has been developed. This paper presents the results of a study of the safety and protective properties of the vaccine with various options of administering, dosing and frequency of use on guinea pigs.Methods: The safety of the vaccine was assessed based on the general condition, behavior and dynamics of a guinea pig weight-gain test. The effectiveness of the new anti-brucellosis vector vaccine was determined by studying its protective effect after conjunctival, intranasal and sublingual administration in doses 105 EID50, 106 EID50 and 107 EID50 during prime and booster vaccinations of animals, followed by challenge with a virulent strain of B. mellitensis 16M infection. For sake of comparison, the commercial B. melitensis Rev.1 vaccine was used as a control. The protective properties of vaccines were assessed by quantitation of Brucella colonization in organs and tissues of infected animals and compared to the control groups.Results: It was found that the vaccine after prime and booster immunization using conjunctival, intranasal and sublingual routes of administration, as well as after using various doses of vaccine were safe for guinea pigs. The most optimal way of using the vaccine has been established: double intranasal immunization of guinea pigs at a dose of 106 EID50, which provides 80% protection of guinea pigs from B. melitensis 16M infection (P < 0.05), comparable to the results of the effectiveness of the commercial B. melitensis Rev.1 vaccine.Conclusions: We developed effective human vaccine against brucellosis and developed its immunization schedule in guinea pig model. We believe that this study is a substantial step for using the vaccine for future pre-clinical and clinical trials in human.
Vanadium-induced coloration in grossite (CaAl4O7) and hibonite (CaAl12O19)
Authors: Ardit Matteo , Cámara Fernando , Hålenius Ulf 
Published: August 2020

AbstractHigh concentrations of vanadium cause very unusual coloration in hibonite (purple) and grossite (light violet) crystals in an exotic mineral assemblage from Sierra de Comechingones (Argentina). In the hibonite (CaAl12O19) structure vanadium ions, in various valence states (divalent, trivalent, and tetravalent), may be distributed over five crystallographic sites with coordinations corresponding to different polyhedra, namely, three unequal octahedra [M1 (D3d), M4 (C3ν), and M5 (Cs)], one M3 tetrahedron (C3ν), and one unusual fivefold-coordinated trigonal bipyramid M2 (D3h). Possible locations of vanadium ions in grossite (CaAl4O7) are limited to two crystallographically distinct sites (T1 and T2, both C1) in tetrahedral coordination.The combination of single-crystal X-ray diffraction and absorption spectroscopy techniques aided by chemical analyses has yielded details on the nature of the vanadium-induced color in both hibonite and grossite crystals. In hibonite, both M4 face-sharing octahedral and M2 trigonal bipyramid sites of the R-block are partially occupied by V3+. Strongly polarized bands recorded at relatively low energies in optical absorption spectra indicate that V2+ is located at the M4 octahedral site of the hibonite R-block. Chemical analyses coupled with an accurate determination of the electron densities at structural sites in hibonite suggest that the vanadium ions occupy about 10 and 5% of the M4 and M2 sites, respectively. For grossite, polarized optical absorption spectra reveal no indications of V2+; all observed absorption bands can be assigned to V3+ in tetrahedral coordination. Although not evident by the observed electron densities at the T sites of grossite (due to the low-V content), longer bond distances, and a higher degree of polyhedral distortion suggest that V3+ is located at the T2 site.
Current Status of SUMOylation Inhibitors
Authors: Brackett Christopher M. , Blagg Brian S. J. 
Published: August 2020

:
SUMOylation has emerged as an important post-translational modification that involves the covalent attachment
of the Small Ubiquitin-like Modifier (SUMO) polypeptide to a lysine residue of a target protein. The enzymatic pathway of
SUMOylation is very similar to ubiquitinylation and involves an activating enzyme, a conjugating enzyme, ligases and deconjugating enzymes. SUMOylation modulates the function of a number of proteins associated with various pathways, and
in fact, dysregulation of the SUMOylation pathway is observed in both cancer and neurological diseases. In many cancers,
the SUMO enzymes are upregulated and SUMO levels correlate directly with prognosis and disease progression. As a result, there has been an emphasis on the discovery and development of inhibitors of SUMOylation. In this review, the latest
advances in SUMOylation inhibitors is described alongside the methods used to discover small molecule SUMOylation inhibitors, which include natural products, peptidomimetics, as well as synthetic derivatives identified via virtual screens.
Role of Glucose Transporters in Drug Membrane Transport
Authors: Wang Xin , Guo Kunkun , Huang Baolin , Lin Zimin , Cai Zheng 
Published: August 2020

Background:Glucose is the main energy component of cellular activities. However, as a polar molecule, glucose cannot freely pass through the phospholipid bilayer structure of the cell membrane. Thus, glucose must rely on specific transporters in the membrane. Drugs with a similar chemical structure to glucose may also be transported through this pathway.Methods:This review describes the structure, distribution, action mechanism and influencing factors of glucose transporters and introduces the natural drugs mediated by these transporters and drug design strategies on the basis of this pathway.Results:The glucose transporters involved in glucose transport are of two major types, namely, Na+-dependent and Na+-independent transporters. Glucose transporters can help some glycoside drugs cross the biological membrane. The transmembrane potential is influenced by the chemical structure of drugs. Glucose can be used to modify drugs and improve their ability to cross biological barriers.Conclusion:The membrane transport mechanism of some glycoside drugs may be related to glucose transporters. Glucose modification may improve the oral bioavailability of drugs or achieve targeted drug delivery.
Nummular Eczema: An Updated Review
Authors: Leung Alexander K.C. , Lam Joseph M. , Leong Kin Fon , Leung Amy A.M. , Wong Alex H.C. , Hon Kam L. 
Published: August 2020

Background:Nummular eczema may mimic diseases that present with annular configuration and the differential diagnosis is broad.Objective:This article aimed to provide an update on the evaluation, diagnosis, and treatment of nummular eczema.Methods:A PubMed search was performed in using the key terms “nummular eczema”, “discoid eczema”, OR “nummular dermatitis”. The search strategy included meta-analyses, randomized controlled trials, clinical trials, observational studies, and reviews. The search was restricted to English literature. The information retrieved from the above search was used in the compilation of the present article. Patents were searched using the key terms “nummular eczema”, “discoid eczema”, OR “nummular dermatitis” in www.google.com/patents and www.freepatentsonline.com.Results:Nummular eczema is characterized by sharply defined, oval or coin-shaped, erythematous, eczematous plaques. Typically, the size of the lesion varies from 1 to 10cm in diameter. The lesions are usually multiple and symmetrically distributed. Sites of predilection include the lower limbs followed by the upper limbs. The lesions are usually intensely pruritic. The diagnosis is mainly clinical based on the characteristic round to oval erythematous plaques in a patient with diffusely dry skin. Nummular eczema should be distinguished from other annular lesions. Dermoscopy can reveal additional features that can be valuable for correct diagnosis. Biopsy or laboratory tests are generally not necessary. However, a potassium hydroxide wet-mount examination of skin scrapings should be performed if tinea corporis is suspected. Because contact allergy is common with nummular eczema, patch testing should be considered in patients with chronic, recalcitrant nummular eczema. Avoidance of precipitating factors, optimal skin care, and high or ultra-high potency topical corticosteroids are the mainstay of therapy. Recent patents related to the management of nummular eczema are also discussed.Conclusion:With proper treatment, nummular eczema can be cleared over a few weeks, although the course can be chronic and characterized by relapses and remissions. Moisturizing of the skin and avoidance of identifiable exacerbating factors, such as hot water baths and harsh soaps may reduce the frequency of recurrence. Diseases that present with annular lesions may mimic nummular eczema and the differential diagnosis is broad. As such, physicians must be familiar with this condition so that an accurate diagnosis can be made, and appropriate treatment initiated.
Amygdalin Decreases Adhesion and Migration of MDA-MB-231 and MCF-7 Breast Cancer Cell Lines
Authors: Mosayyebi Bashir , Mohammadi Leila , Kalantary-Charvadeh Ashkan , Rahmati Mohammad 
Published: August 2020

Background:
Cell adhesion, as dynamic interactions between cell-cell and cell-matrix,
has an essential role in cancer cell migration. Integrins as cell membrane receptors are involved in
cell adhesion and signal transduction. Aberrant expression of integrins is associated with the cancer
cell adhesion.

Objective:
Targeting the process of cell adhesion and migration could be helpful to prevent cancer
cell metastasis. Amygdalin is a cyanoglycoside compound with anti-cancer properties, while its effect
on cancer cell adhesion is not completely clear.

Methods:
The cytotoxic effect of amygdalin on breast cancer cell lines (MCF-7 and MDA-MB-
231) and human skin fibroblast cell line as a normal cell, was evaluated through MTT assay. The
cell adhesion assay and wound healing assay were performed to determine amygdalin effects on adhesion
and migration of cancer cells. Further analysis was carried out to evaluate integrin α and β
levels through real-time PCR.

Results:
We demonstrated that amygdalin diminished the cell viability of both cell lines in a time
and dose-dependent manner, while amygdalin did not have any toxicity on the human skin fibroblast
cell line in the same dosages. Following amygdalin treatment, the adhesion of both studied
cell lines to fibronectin and collagen I decrease, and this reduction is significantly greater in the
case of binding to fibronectin compared to binding to collagen. The MDA-MB-231 cell migration
was decreased greater than MCF-7 cells. The levels of α and β integrin were differentially regulated
by amygdalin in both cancer cell lines.

Conclusion:
These results suggest that depending on cancer cell lines, amygdalin affects cancer
cell adhesion and migration.
Dermal Filler types, Effect on soft tissue and Life Style correlation
Authors: Mohamed Dalia A 
Published: August 2020

One of the most common manifestation in our time, especially among girls, is those procedures on the skin or maintaining or to modify some of the changes in the skin, such as those that come due to aging or any other cosmetic reasons. Fillers and Botox are two of the most popular procedures. Dermal fillers are effective treatments used to soften and reduce wrinkles and deep lines, fill out the cheeks and smooth facial contours. There are four main types of injectable dermal fillers, including fat, collagen, hyaluronic acid, and microsphere-containing carriers of another material such as polymethyl methacrylate (PMMA). So that to understand any type of injection, it is important to look at its history for valuable lessons and for successful progress. Honestly, it is very interesting to see what and where the world gets in the last 40 years of injectable. Today, we will be examining the brief history of dermal fillers from their bovine collagen roots, to the advanced fillers that are available today. In this review, we aimed to show some types of dermal fillers including a variety of its complication in soft tissue. Also, we try to correlate the factor of lifestyle with its variant effects.
Role of Health Literacy in Health-Related Information-Seeking Behavior Online: Cross-sectional Study
Authors: Lee Hee Yun , Jin Seok Won , Henning-Smith Carrie , Lee Jongwook , Lee Jaegoo 
Published: August 2020

Background
The internet has emerged as a main venue of health information delivery and health-related activities. However, few studies have examined how health literacy determines online health-related behavior.

Objective
The aim of this study was to investigate the current level of health-related information-seeking using the internet and how health literacy, access to technology, and sociodemographic characteristics impact health-related information-seeking behavior.

Methods
We conducted a cross-sectional study through a survey with Minnesotan adults (N=614) to examine their health literacy, access to technology, and health-related information-seeking internet use. We used multivariate regression analysis to assess the relationship between health-related information-seeking on the internet and health literacy and access to technology, controlling for sociodemographic characteristics.

Results
Better health literacy (β=.35, SE 0.12) and greater access to technological devices (eg, mobile phone and computer or tablet PC; β=.06, SE 0.19) were both associated with more health-related information-seeking behavior on the internet after adjusting for all other sociodemographic characteristics. Possession of a graduate degree (β=.28, SE 0.07), female gender (β=.15, SE 0.05), poor health (β=.22, SE 0.06), participation in social groups (β=.13, SE 0.05), and having an annual health exam (β=.35, SE 0.12) were all associated with online health-related information-seeking.

Conclusions
Our findings indicate that access to online health-related information is not uniformly distributed throughout the population, which may exacerbate disparities in health and health care. Research, policy, and practice attention are needed to address the disparities in access to health information as well as to ensure the quality of the information and improve health literacy.
Coastal groundwater aquifer characterization from geoelectrical measurements- A case study at Kalapara, Patuakhali, Bangladesh.
Authors: Khalil Mohammad Ibrahim 
Published: August 2020

Vertical electrical sounding has been carried out in a coastal area in the southern part of Bangladesh to locate the groundwater aquifers containing fresh water. The Interpex1X1Dv3 computer program was used to process the field apparent resistivity data sets obtained from the vertical electrical sounding. Geoelectric layers were identified in the context of resistivity and thickness from the vertical electrical sounding data. From the initial parameters layered model was achieved using the inversion technique. Correlation of the obtained layer model with a nearby lithologic log concludes the groundwater aquifer system of the area. From the electrical properties of the subsurface layers, water bearing layers were detected and characterized. Very fine sand geoelectric layer with a thickness varying from 20 to 143 meters is an upper aquifer and has 0.66–14.02 Ωm apparent resistivity value. Fine sand geoelectric layer with 0.21-5.99 Ωm apparent resistivity value is lower aquifer with maximum thickness ~250 meters. From the resistivity value, it is observed that the upper aquifer contains saline to brackish-fresh water while the resistivity value of the lower aquifer indicates that it contains saline water. The water quality of the upper zone varies geographically from the southern to the northern part in the investigated area. The water quality of the upper aquifer is fresh in the northern part of the study while lower aquifer contains saline water there.
The Histological Picture of Indication Biopsies in the First 2 Weeks after Kidney Transplantation
Authors: Van Loon Elisabet , Lerut Evelyne , Senev Aleksandar , Coemans Maarten , Pirenne Jacques , Monbaliu Diethard , Jochmans Ina , Sainz Barriga Mauricio , De Vusser Katrien , Van Craenenbroeck Amaryllis H. , Sprangers Ben , Emonds Marie-Paule , Kuypers Dirk , Naesens Maarten 
Published: August 2020

Background and objectives
In preclinical studies, ischemia-reperfusion injury and older donor age are associated with graft inflammation in the early phase after transplantation. In human kidney transplantation, impaired allograft function in the first days after transplantation is often adjudicated to donor- and procedure-related characteristics, such as donor age, donor type, and ischemia times.

Design, setting, participants, & measurements
In a cohort of 984 kidney recipients, 329 indication biopsies were performed within the first 14 days after transplantation. The histologic picture of these biopsies and its relationship with alloimmune risk factors and donor- and procedure-related characteristics were studied, as well as the association with graft failure. Multivariable Cox models were applied to quantify the cause-specific hazard ratios for early rejection and early inflammatory scores, adjusted for potential confounders. For quantification of hazard ratios of early events for death-censored graft failure, landmark analyses starting from day 15 were used.

Results
Early indication biopsy specimens displayed microvascular inflammation score ≥2 in 30% and tubulointerstitial inflammation score ≥2 in 49%. Rejection was diagnosed in 186 of 329 (57%) biopsies and associated with the presence of pretransplant donor-specific HLA antibodies and the number of HLA mismatches, but not nonimmune risk factors in multivariable Cox proportional hazards analysis. In multivariable Cox proportional hazards analysis, delayed graft function, the graft dysfunction that prompted an early indication biopsy, HLA mismatches, and pretransplant donor-specific HLA antibodies were significantly associated with a higher risk for death-censored graft failure, whereas early acute rejection was not.

Conclusions
Indication biopsies performed early after kidney transplantation display inflammatory changes related to alloimmune risk factors. Nonimmune risk factors for ischemia-reperfusion injury, such as cold and warm ischemia time, older donor age, and donor type, were not identified as strong risk factors for early inflammation after human kidney transplantation.
ANALISIS USAHA IKAN HIAS AIR TAWAR DI KOTA JAMBI
Authors: Hadisaputra Dodi , Ernawati  , Suandi  
Published: August 2020

Ornamental fish is a fish that has a distinctive shape, color and character so as to create an aquarium atmosphere that supports spatial layout and is able to provide a peaceful atmosphere. The purpose of this study was to determine the description of ornamental fish business and analyze the feasibility of ornamental fish business in Jambi City. The qualitative method is used to describe descriptively the general description of the location of the study and the characteristics of ornamental fish farmers, while the quantitative method uses the Analysis of Income and Revenue of ornamental fish business, cost analysis, income analysis and cost balance (R/C Ratio), Net Benefits - Cost Ratios (Net B/C), and institutionally descriptive for the betta fish, guppy and botia ornamental fish business. Overall, the general description of ornamental fish farming business in Jambi City is conducted conventionally. The average R/C ratio of the Betta ornamental fish business is 2.60, guppy is 2.02 and botia is 1.22. The highest average NPV in the betta ornamental fish in the mid-scale farming business is Rp. 60,745,160.71, guppy on a large scale is Rp. 31,385,065.48, and botia on a large scale with a value of Rp. 78,034,144.35. Overall, this ornamental fish business has an NPV value of> 0. The ornamental fish business in Jambi City is feasible to run and develop, betta ornamental fish business on a small scale with an average B/C Ratio of 1.15 and medium with an average value of average 1.60, guppy on a small scale with an average value of 1.02, and botia on a medium scale with an average value of 1.00 and large with a value of an average of 1.22.
Keywords: Ornamental Fish, Jambi City.
STRATEGI ADAPTASI PETANI DALAM MENGHADAPI RENDAHNYA HARGA JUAL KELAPA SAWIT DI KECAMATAN SUNGAI BAHAR KABUPATEN MUARO JAMBI
Authors: Andini Fiona , Muchlis Fuad , Farida Aulia 
Published: August 2020

This study aims to determine the adaptation strategies of farmers in the face of low prices for oil palm in Sungai Bahar District. The data used are primary data obtained from direct interviews with respondents and secondary data obtained from literature and related institutions. The method used in this research is mixed methods. Data analysis is done by collecting data and analyzing quantitative data in the first stage, then collecting data and analyzing qualitative data in the second stage, then analyzing the overall data to then draw conclusions from the analysis of the data. The analysis methods are: (1) Data reduction; (2) Presentation of data and; (3) Drawing conclusions.
The results showed that the adaptation strategies used were: (1) active strategy, becoming an oil palm farm laborer, opening a side business; (2) a passive strategy, utilizing home yards to grow horticultural crops, raising / raising chickens; (3) network strategy, borrowing money from relatives / neighbors, borrowing money from tauke and borrowing / borrowing daily necessities at the shop / shop.