bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surface hydrophobicity: effect of alkyl chain length and network homogeneity
Authors: Chen Wenqian , Karde Vikram , Cheng Thomas N. H. , Ramli Siti S. , Heng Jerry Y. Y. 
Published: November 2020

AbstractUnderstanding the nature of hydrophobicity has fundamental importance in environmental applications. Using spherical silica nanoparticles (diameter = 369 ± 7 nm) as the model material, the current study investigates the relationship between the alkyl chain network and hydro-phobicity. Two alkyl silanes with different chain length (triethoxymethylsilane (C1) vs. trimethoxy(octyl)silane (C8)) were utilised separately for the functionalisation of the nanoparticles. Water contact angle and inverse gas chromatography results show that the alkyl chain length is essential for controlling hydrophobicity, as the octyl-functionalised nanoparticles were highly hydrophobic (water contact angle = 150.6° ± 6.6°), whereas the methyl-functionalised nanoparticles were hydrophilic (i.e., water contact angle = 0°, similar to the pristine nanoparticles). The homogeneity of the octyl-chain network also has a significant effect on hydrophobicity, as the water contact angle was reduced significantly from 148.4° ± 3.5° to 30.5° ± 1.0° with a methyl-/octyl-silane mixture (ratio = 160:40 µL·g−1 nanoparticles).
Characterising populations living close to intensive farming and composting facilities in England
Authors: Douglas Philippa , Fecht Daniela , Jarvis Deborah 
Published: November 2020

Abstract
Bioaerosol exposure has been linked to adverse respiratory conditions. Intensive farming and composting facilities are important anthropogenic sources of bioaerosols. We aimed to characterise populations living close to intensive farming and composting facilities. We also infer whether the public are becoming more concerned about anthropogenic bioaerosol emissions, using reports of air pollution related incidents attributed to facilities. We mapped the location of 1,257 intensive farming and 310 composting facilities in England in relation to the resident population and its characteristics (sex and age), area characteristics (deprivation proxy and rural/urban classification) and school locations stratified by pre-defined distance bands from these bioaerosol sources. We also calculated the average number of air pollution related incidents per year per facility. We found that more than 16% of the population and 15% of schools are located within 4,828 m of an intensive farming facility or 4,000 m of a composting facility; few people (0.01 %) live very close to these sites and tend to be older people. Close to composting facilities, populations are more likely to be urban and more deprived. The number of incidents were attributed to a small proportion of facilities; population characteristics around these facilities were similar. Results indicate that populations living near composting facilities (particularly>250 to ⩽ 4,000 m) are mostly located in urban areas (80%–88% of the population), which supports the need for more community health studies to be conducted. Results could also be used to inform risk management strategies at facilities with higher numbers of incidents.
Long-term effects of intensive B cell depletion therapy in severe cases of IgG4-related disease with renal involvement
Authors: Quattrocchio Giacomo , Barreca Antonella , Demarchi Andrea , Fenoglio Roberta , Ferro Michela , Del Vecchio Giulio , Massara Carlo , Rollino Cristiana , Sciascia Savino , Roccatello Dario 
Published: November 2020

AbstractIgG4-related disease (IgG4-RD) is an immune-mediated disorder often showing elevated serum IgG4 concentrations, dense T and B lymphocyte infiltration, and IgG4-positive plasma cells and storiform fibrosis. We prospectively evaluated for 4 years 5 patients with histologically proven IgG4-RD of whom 3 had tubulointerstitial nephritis (TIN) and 2 had retroperitoneal fibrosis (RPF). They received an intensive B depletion therapy with rituximab. The estimated glomerular filtration rate of TIN patients after 1 year increased from 9 to 24 ml/min per 1.73 m2. IgG/IgG4 dropped from 3236/665 to 706/51 mg/dl, C3/C4 went up from 49/6 to 99/27 mg/dl, and the IgG4-RD responder index fell from 10 to 1. CD20+ B cells decreased from 8.7 to 0.5%. A striking drop in interstitial plasma cell infiltrate as well as normalization of IgG4/IgG-positive plasma cells was observed at repeat biopsy. Both clinical and immunological improvement persisted over a 4-year follow-up. Treating these patients who were affected by aggressive IgG4-RD with renal involvement in an effort to induce a prolonged B cells depletion with IgG4 and cytokine production decrease resulted in a considerable rise in eGFR, with IgG4-RD RI normalization and a noteworthy improvement in clinical and histological features. Furthermore, the TIN subgroup was shown not to need for any maintenance therapy.
Association between the CEBPA and c-MYC genes expression levels and acute myeloid leukemia pathogenesis and development
Authors: Krygier Adrian , Szmajda-Krygier Dagmara , Sałagacka-Kubiak Aleksandra , Jamroziak Krzysztof , Żebrowska-Nawrocka Marta , Balcerczak Ewa 
Published: November 2020

AbstractCEBPA and c-MYC genes belong to TF and play an essential role in hematologic malignancies development. Furthermore, these genes also co-regulate with RUNX1 and lead to bone marrow differentiation and may contribute to the leukemic transformation. Understanding the function and full characteristics of selected genes in the group of patients with AML can be helpful in assessing prognosis, and their usefulness as prognostic factors can be revealed. The aim of the study was to evaluate CEBPA and c-MYC mRNA expression level and to seek their association with demographical and clinical features of AML patients such as: age, gender, FAB classification, mortality or leukemia cell karyotype. Obtained results were also correlated with the expression level of the RUNX gene family. To assess of relative gene expression level the qPCR method was used. The expression levels of CEBPA and c-MYC gene varied among patients. Neither CEBPA nor c-MYC expression levels differed significantly between women and men (p=0.8325 and p=0.1698, respectively). No statistically significant correlation between age at the time of diagnosis and expression of CEBPA (p=0.4314) or c-MYC (p=0.9524) was stated. There were no significant associations between relative CEBPA (p=0.4247) or c-MYC (p=0.4655) expression level and FAB subtype and mortality among the enrolled patients (p=0.5858 and p=0.8437, respectively). However, it was observed that c-MYC and RUNX1 expression levels were significantly positively correlated (rS=0.328, p=0.0411). Overall, AML pathogenesis involves a complex interaction among CEBPA, c-MYC and RUNX family genes.
The Four Levels of Awakening
Authors: Anālayo Bhikkhu 
Published: November 2020

AbstractThe early discourses present the realization of four levels of awakening as the chief purpose of mindfulness practice. A survey of the opinions of various scholars, alleging these four levels to be a later development, shows that the main arguments proposed in support of this assessment are unconvincing. The testimony provided by a comparative study of the early discourses instead conveys the impression that these four levels of awakening are an integral part of the teachings of early Buddhism in the form in which they have been preserved in the textual records. These four levels depict a gradual purification of the mind which can be achieved through the cultivation of insight based on the practice of mindfulness.
Robotic rectal resection: oncologic outcomes
Authors: Fiorillo Claudio , Quero Giuseppe , Menghi Roberta , Cina Caterina , Laterza Vito , De Sio Davide , Longo Fabio , Alfieri Sergio 
Published: November 2020

AbstractRobotic surgery has progressively gained popularity in the treatment of rectal cancer. However, only a few studies on its oncologic effectiveness are currently present, with contrasting results. The purpose of this study is to report a single surgeon’s experience on robotic rectal resection (RRR) for cancer, focusing on the analysis of oncologic outcomes, both in terms of pathological features and long-term results. One-hundred and twenty-two consecutive patients who underwent RRR for rectal cancer from January 2013 to December 2019 were retrospectively enrolled. Patients’ characteristics and perioperative outcomes were collected. The analyzed oncologic outcomes were pathological features [distal (DM), circumferential margin (CRM) status and quality of mesorectal excision (TME)] and long-term outcomes [overall (OS) and disease-free survival (DFS)]. The mean operative time was 275 (± 60.5) minutes. Conversion rate was 6.6%. Complications occurred in 27 cases (22.1%) and reoperation was needed in 2 patients (1.5%). The median follow-up was 30.5 (5.9–86.1) months. None presented DM positivity. CRM positivity was 2.5% (2 cases) while a complete TME was reached in 94.3% of cases (115 patients). Recurrence rate was 5.7% (2 local, 4 distant and 1 local plus distant tumor relapse). OS and DFS were 90.7% and 83%, respectively. At the multivariate analysis, both CRM positivity and near complete/incomplete TME were recognized as negative prognostic factors for OS and DFS. Under appropriate logistic and operative conditions, robotic surgery for rectal cancer proves to be oncologically effective, with adequate pathological results and long-term outcomes. It also offers acceptable peri-operative outcomes, further confirming the safety and feasibility of the technique.
Soil erosion risk and sediment yield assessment with universal soil loss equation and GIS: in Dijo watershed, Rift valley Basin of Ethiopia
Authors: Bekele Bagegnehu , Gemi Yenealem 
Published: November 2020

AbstractSoil erosion is the main drivers in the world and Ethiopia in particular. This study has been conducted at Dijo watersheds in the Rift valley Basins of Ethiopia to estimate soil erosion rate and identify erosion hotspot areas for proper planning using Geographic Information System and Universal Soil Loss Equation adapted to Ethiopian condition. 64 years mean annual rainfall data for estimating erosivity factor, digital soil map for estimating soil erodibility factor, Digital Elevation Model for estimating topographic (LS) factor, Land use land cover for cover factor detection from Ethiopian ministry of water resources. The result reveals that the soil loss ranges from 0 ton/ha/year in flat slope to 38.09 ton/ha/year from steep slopes. The average soil loss rate is 2.2 tons per hectare per year and has been classified into three erosion severity classes as very low, low and moderate. The result also reveals that most of the watershed erosion severity evaluated under very low and low soil erosion severity classes covering 97.3% of the watershed areas which is due to the effect of mixed plantation of various tree and terraces. However, moderate soil erosion in the upper parts of the watershed could be due to the inherent characteristics of vertisols, lack of vegetation cover and terraces which should be given first priority for conservation interventions. From the gross soil erosion, 43,762 ton/year sediment yields have been estimated at watershed outlet. Policy aim at keeping land productivity will need to focus to reduce low and moderate soil erosion through terracing, inter-cropping, contour farming, strip cropping, conservation tillage, mulching and biological stabilizers based on their slope range, soil type and land use type. The current finding on erosion was evaluated based on the past 10 years land use land cover scenario; therefore, soil erosion might be reduced if the current land use land cover scenario considered. Finally, the integration of USLE and GIS is an effective tool in mapping the spatial distribution of soil erosion from the entire watershed. The moderate and low soil erosion severity areas should be managed through terracing, inter-cropping, contour farming, strip cropping, conservation tillage, mulching and biological stabilizers based on their slope range, soil type and land use type. Free grazing and cultivation of steep slope(Northern parts) contributed for moderate soil erosion in the watershed should be managed by cut–carry system, limiting the number of cattle units to be grazed in the specific plot of land and leaving the marginal steep slope areas with no ground covers for natural regeneration. Finally, the current finding on erosion was evaluated based on the past 10-year land use land cover scenario. Therefore, the soil erosion could be reduced if the current land use land cover scenario is considered.
Solubility of Precursors and Carbonation of Waterglass-Free Geopolymers
Authors: Werling N. , Dehn F. , Krause F. , Steudel A. , Schuhmann R. , Emmerich K. 
Published: November 2020

AbstractGeopolymers have the potential to function as an environmentally friendly substitute for ordinary Portland cement, with up to 80% less CO2 emission during production. The effect is best utilized for geopolymers prepared with amorphous silica instead of waterglass (Na2xSiyO2y+x) to adjust the Si:Al ratio. The reactivity of the precursors with the alkaline activator affects the final mineralogical properties of the binder. The purpose of the present study was to investigate the amount of different phases formed during geopolymerization and to understand the quantitative evolution of carbonation during geopolymer synthesis by determining the solubility of metakaolinite and amorphous SiO2 in NaOH at various concentrations. The solubility was studied by ICP-OES measurements. X-ray diffraction was used for qualitative and quantitative phase analysis of the geopolymers. The solubility of the precursors increased with calcination temperature of metakaolinite, reaction time for amorphous SiO2, and at higher NaOH concentrations. Partial dissolution resulted in free Na+, which is a source for the formation of carbonates in the geopolymers. Thermonatrite occurred prior to trona formation in all samples.
Metabolic Profile of Patients with Severe Endometriosis: a Prospective Experimental Study
Authors: Murgia Federica , Angioni Stefano , D’Alterio Maurizio Nicola , Pirarba Silvia , Noto Antonio , Santoru Maria Laura , Tronci Laura , Fanos Vassilios , Atzori Luigi , Congiu Francesca 
Published: November 2020

AbstractEndometriosis is a common disease affecting women in reproductive age. There are several hypotheses on the pathogenesis of this disease. Often, its lesions and symptoms overlap with those of many other medical and surgical conditions, causing a delay in diagnosis. Metabolomics represents a useful diagnostic tool for the study of metabolic changes during a different physiological or pathological status. We used1H-NMR to explore metabolic alteration in a cohort of patients with endometriosis in order to contribute to a better understanding of the pathophysiology of the disease and to suggest new useful biomarkers. Thirty-seven patients were recruited for the metabolomic analysis: 22 patients affected by symptomatic endometriosis and 15 not affected by it. Their serum samples were collected and analyzed with1H-NMR. Multivariate statistical analysis was conducted, followed by univariate and pathway analyses. Partial Least Square Discriminant Analysis (PLS-DA) was performed to determine the presence of any differences between the non-endometriosis and endometriosis samples (R2X = 0.596,R2Y = 0.713,Q2 = 0.635, andp < 0.0001). β-hydroxybutyric acid and glutamine were significantly increased, whereas tryptophan was significantly decreased in the endometriosis patients. ROC curves were built to test the diagnostic power of the metabolites (β-hydroxybutyric acid: AUC = 0.85 CI = 0.71–0.99; glutamine: AUC = 0.83 CI = 0.68–0.98; tryptophan: AUC = 0.75 CI = 0.54–0.95; β-hydroxybutyric acid + glutamine + tryptophan AUC = 0.92 CI = 0.81–1). The metabolomic approach enabled the identification of several metabolic alterations occurring in women with endometriosis. These findings may provide new bases for a better understanding of the pathophysiological mechanisms of the disease and for the discovery of new biomarkers. Trial registration number NCT02337816
Lumen and mucosa-associatedLactobacillus rhamnosusfrom the intestinal tract of organ donors
Authors: Marsh Alan J. , Yaya Al-Mounawara A. , Ng Sandy , Chandrashekhar Kshipra , Roach Jeff , Magness Scott T. , Azcarate-Peril M. Andrea 
Published: November 2020

ABSTRACTKnowledge of the intra-individual spatial and regional distribution of intestinal microbial populations is essential to understand gut host–microbial interactions. In this study, we performed a compositional analysis of luminal and mucosal samples from the small and large intestine of four organ donors by 16S rRNA amplicon sequencing and high-throughput quantitative polymerase chain reaction. Since the human microbiota is subject to selection pressure at lower taxonomic levels, we isolated over 400 bacterial strains and investigated strain-level variation of 11Lactobacillus rhamnosusfrom different intestinal regions. Results substantiate reported inter-individual variability as well as intra-individual differences along the gastrointestinal tract. Although the luminal and mucosal-associated communities were similar within individuals, relative abundance reflected the donors’ demographic and potential pathologies. The total bacterial load of all donors increased from small intestine to colon, whileBifidobacteriumwas in greater abundance in the small intestine. Comparative genomic analysis ofL. rhamnosusshowed the strains segregated into two distinct clusters and identified no features specific to location. Analysis revealed genetic differences for exopolysaccharide production, carbohydrate utilization, pilus formation and vitamin K biosynthesis between clusters. This study contributes to the understanding of niche-specific microbial communities, encouraging subsequent studies to better understand microbial signatures at lower taxonomic levels.
Expanding mandatory healthcare personnel immunization beyond influenza: Impact of a broad immunization program with enhanced accountability
Authors: Talbot Thomas R. , Schimmel Ruth , Swift Melanie D. , Rolando Lori A. , Johnson Rochelle T. , Muscato Jannis , Sternberg Paul , Dubree Marilyn , McGown Paula W. , Yarbrough Mary I. , Hickson Gerald B. 
Published: November 2020

AbstractObjective:Evaluation of a mandatory immunization program to increase and sustain high immunization coverage for healthcare personnel (HCP).Design:Descriptive study with before-and-after analysis.Setting:Tertiary-care academic medical center.Participants:Medical center HCP.Methods:A comprehensive mandatory immunization initiative was implemented in 2 phases, starting in July 2014. Key facets of the initiative included a formalized exemption review process, incorporation into institutional quality goals, data feedback, and accountability to support compliance.Results:Both immunization and overall compliance rates with targeted immunizations increased significantly in the years after the implementation period. The influenza immunization rate increased from 80% the year prior to the initiative to >97% for the 3 subsequent influenza seasons (P < .0001). Mumps, measles and varicella vaccination compliance increased from 94% in January 2014 to >99% by January 2017, rubella vaccination compliance increased from 93% to 99.5%, and hepatitis B vaccination compliance from 95% to 99% (P < .0001 for all comparisons). An associated positive effect on TB testing compliance, which was not included in the mandatory program, was also noted; it increased from 76% to 92% over the same period (P < .0001).Conclusions:Thoughtful, step-wise implementation of a mandatory immunization program linked to professional accountability can be successful in increasing immunization rates as well as overall compliance with policy requirements to cover all recommended HCP immunizations.
BUSINESS AND LOCAL TAXATION IN THE PHILIPPINES
Authors: Tans Ryan 
Published: November 2020

AbstractThis article argues that weak local governments increase levels of taxation by “borrowing” institutional capacity from certain types of businesses. While many businesses lobby against taxation, businesses that are locally owned, nationally connected, and logistically complex build robust associations that support taxation. These types of businesses benefit from improvements in public infrastructure, so they empower their associations to monitor members’ tax compliance and to pressure officials to uphold their spending commitments. The article demonstrates the necessity of business support for taxation in the absence of state capacity by comparing two Philippine cities that differ in their ability to tax despite a number of similarities between them. The case studies show that tax increases co-varied with business support, and that business support waxed and waned depending on over-time variation in the capability of business associations to discourage tax evasion and to enforce official commitments to spend on infrastructure.
Female sex and femininity independently associate with common somatic symptom trajectories
Authors: Ballering Aranka V. , Wardenaar Klaas J. , olde Hartman Tim C. , Rosmalen Judith G. M. 
Published: November 2020

AbstractBackgroundMultiple predictors have been associated with persistent somatic symptoms. However, previous studies problematically defined the persistence of symptoms, conflated participants' sex and gender, and focused on patient populations. Therefore, we studied associations between predictors, especially sex and gender, and longitudinal patterns of somatic symptoms in the general adult population. We also assessed whether predictors for persisting symptoms differ between sexes.MethodTo identify developmental trajectories of somatic symptoms, assessed by the SCL-90 SOM, we used latent class trajectory modeling in the Dutch Lifelines Cohort Study [N = 150 494; 58.6% female; median time to follow-up: 46.0 (min–max: 22.0–123.0) months]. To identify predictors of trajectories, we applied multiple logistic regression analyses. Predictors were measured by surveys at baseline and a composite gender index was previously developed.ResultsA five-class linear LCGA model fitted the data best: 93.7% of the population had a stable symptom trajectory, whereas 1.5% and 4.8% of the population had a consistently increasing or decreasing symptom trajectory, respectively. Female sex predicted severe, stable symptom severity (OR 1.74, 95% CI 1.36–2.22), but not increasing symptom severity (OR 1.15, 95% CI 0.99–1.40). Femininity was protective hereof (OR 0.60, 95% CI 0.44–0.82 and OR 0.66, 95% CI 0.51–0.85, respectively). Merely a few predictors of symptom severity, for instance hours of paid employment and physical functioning, differed in strength between sexes. Yet, effect sizes were small.ConclusionFemale sex and femininity predict symptom trajectories. No large sex differences in the strength of additional predictors were found, thus it may not be clinically useful to distinguish between predictors specific to male or female patients of persistent somatic symptoms.