bluuebunny/crossref_metadata_2025_split huggingface dataset:
Activities of regulatory RNAs that affect development of tumor cells in patients with laryngeal cancer
Authors: Салеева Д.В. , Михайлов В.Ф. , Шуленина Л.В. , Виноградов В.В. , Бахтин А.А. , Акопян К.В. , Незнанова М.В. , Засухина Г.Д. 
Published: December 2020

Цель. Определение прогностической значимости и роли экспрессии некодирующих РНК (длинные РНК и микроРНК), и белка кодирующих генов в патогенезе рака гортани. Методика. Исследован биопсийный материал и периферическая кровь 35 пациентов с диагнозом плоскоклеточный рак гортани (ПРГ) с классификацией от T1N0M0 до T4N1M0. Контролем служили образцы близлежащей гистологически неизмененной ткани гортани тех же больных. Для оценки экспрессии генов исследовали кровь 27 здоровых доноров. Содержание мРНК генов ( р53, CCND1, ORAOV1, hPTEN ), длинных некодирующих РНК (днРНК): NEAT1, MALAT1, ROR , а также зрелых микроРНК (miR-21, miR-27a, miR-34a, miR-101, miR-124, miR-125b, miR-181а) в опухолевой ткани и крови определяли методом ПЦР в реальном времени (ПЦР-РВ). Результаты. Выявлено увеличение содержания мРНК генов CCND1, hPTEN , днРНК NEAT1, MALAT1 и miR-21, miR-27a в крови у пациентов с ПРГ. Установлено, что уровень мРНК генов CCND1, ORAOV1 был значимо выше при исследовании биоптатов у больных 3-й - 4-й стадии, чем у больных 1-й - 2-й стадии заболевания. Такая же закономерность выявлена для днРНК NEAT1, MALAT1 и для miR-101. Экспрессия miR-27a и miR-124 на более поздних стадиях болезни была ниже, чем у пациентов 1-2 стадии. Заключение. Выявлена возможность использования исследованных днРНК, микроРНК и мРНК белоккодирующих генов для индивидуального прогноза заболевания при создании панели биомаркеров.
Aim. To study the role of non-coding RNA (long RNAs and microRNAs) expression and protein-coding genes in the pathogenesis of laryngeal cancer to determine their prognostic significance for oncotransformation. Methods. The expression of long non-coding RNAs, microRNAs and protein-coding genes was examined in biopsy samples (fresh frozen tissue) and peripheral blood samples from 35 patients with laryngeal squamous cell cancer (LSCC) at T1N0M0 - T4N1M0 stages. Samples of surrounding, histologically unchanged tissues collected from the same patients were used as control. Gene expression was evaluated in blood samples from 27 healthy donors. Contents of gene mRNAs ( p53, CCND1, ORAOV1, hPTEN ), long non-coding RNAs (IncRNA) ( NEAT1, MALAT1, ROR ), and mature miRNAs (miR-21, miR-27a, miR-34a, miR-101, miR-124, miR -125b, miR-181a) were measured in tissue and blood using real-time PCR. Results. Contents of CCND1 and hPTEN gene mRNAs, lncRNAs ( NEAT1, MALAT1), miR-21, and miR-27a were increased in blood of patients with LSCC. Levels of CCND1 and ORAOV1 gene mRNAs were significantly higher in biopsy samples from stage 3-4 patients compared to stage 1-2 patients. A similar expression pattern was observed for lncRNAs NEAT1 and MALAT1 and miR-101. On the other hand, expression of miR-27a and miR-124 was lower at later stages than at stages 1-2. Conclusion. The studied lncRNAs, microRNAs and protein-coding genes can be used in development of a biomarker panel for individual prognosis of the disease.
Effects of fibrinogen concentrate, factor XIII, and thrombin-activatable fibrinolysis inhibitor on clot firmness and fibrinolytic resistance in the model of hyperfibrinolysis
Authors: Будник И.А. , Морозова О.Л. , Цымбал А.А. , Шенкман Б. , Эйнав Ю. 
Published: December 2020

Цель исследования - изучение возможности коррекции формирования кровяного сгустка и его фибринолитической устойчивости с помощью концентратов фибриногена, фактора XIII и активируемого тромбином ингибитора фибринолиза (TAFI) в модели гиперфибринолиза in vitro . Методика. В образцы цитратной крови, полученной от 24 взрослых здоровых добровольцев, добавляли концентрат фибриногена, фактора XIII и/или TAFI. Фибринолиз индуцировали добавлением тканевого активатора плазминогена. Свертывание крови индуцировали рекальцификацией и добавлением препарата тканевого фактора. Формирование и лизис сгустка изучали методом ротационной тромбоэластометрии. Результаты. Индукция фибринолиза не влияла на время свертывания и скорость формирования сгустка, но значительно уменьшала максимальную плотность сгустка и вызывала его лизис. Концентрат фибриногена замедлял скорость лизиса сгустка; концентрат фактора XIII усиливал механическую прочность сгустка и замедлял скорость его лизиса, не влияя при этом на время начала лизиса; TAFI усиливал механическую прочность и значительно отдалял время начала лизиса, оказывая тем самым наибольший корригирующий эффект. Заключение. Полученные данные демонстрируют потенциальную возможность коррекции гемостатического потенциала крови при гиперфибринолизе с помощью концентратов фибриногена, фактора XIII и TAFI, которые могут стать альтернативой традиционным антифибринолитикам.
Aim. To investigate effects of fibrinogen concentrate, factor XIII, and thrombin-activatable fibrinolysis inhibitor (TAFI) on clot formation and fibrinolytic resistance using an in vitro model of hyperfibrinolysis. Methods. Citrated whole blood from 24 adult healthy volunteers was supplemented with fibrinogen concentrate, factor XIII, and/or TAFI. Fibrinolysis was induced by tissue plasminogen activator. Clotting was induced by recalcification and addition of tissue factor and monitored using rotation thromboelastometry. Results. Induction of fibrinolysis did not affect clotting time and the rate of clot formation but significantly reduced the maximum clot firmness and caused lysis of a clot. Addition of fibrinogen concentrate to blood reduced the rate of clot lysis without affecting clot firmness or lysis onset time; addition of factor XIII improved clot firmness and reduced clot lysis rate without affecting lysis onset time; TAFI improved clot firmness and considerably delayed the onset of clot lysis thereby providing the greatest antifibrinolytic effect. Conclusion. Fibrinogen concentrate, factor XIII, and TAFI may potentially serve as an alternative to traditional antifibrinolytic agents and be beneficial for the treatment of patients with hyperfibrinolysis.
O ACESSO À INFORMAÇÃO COMO INSTRUMENTO À EDUCAÇÃO INCLUSIVA: UM OLHAR A PARTIR DO DESENVOLVIMENTO SUSTENTÁVEL
Authors: Lazaretti Isadora , Both Voos Yana Paula , Stecanella Elouise Mileni 
Published: December 2020

O presente trabalho tem como tema central os direitos fundamentais no que se refere ao acesso à informação como instrumento à educação inclusiva, a partir da perspectiva da Agenda 2030 da Organização das Nações Unidas (ONU). Para tanto, fora proposta uma análise acerca da Agenda 2030, bem como um estudo bibliográfico sobre o direito humano fundamental ao acesso à informação e seu impacto na educação. A pesquisa utilizou a técnica de pesquisa bibliográfica, por sua natureza exploratória, por meio da utilização de artigos da base de dados da CAPES, além da legislação brasileira, documentos internacionais oficiais e outros artigos e obras sobre a temática.
ТРАНСФОРМАЦИЯ ИНСТРУМЕНТАРИЯ СТРАТЕГИЧЕСКОГО УПРАВЛЕНИЯ РАЗВИТИЕМ ЭКСПОРТНОГО ПОТЕНЦИАЛА РЕГИОНА В УСЛОВИЯХ НЕОПРЕДЕЛЕННОСТИ ЭКОНОМИЧЕСКОЙ СИТУАЦИИ
Authors: Уварова Галина Геннадьевна , Мащенко Юлия Александровна , Садовникова Юлия Юрьевна , Тимейчук Людмила Николаевна 
Published: December 2020

Цель работы. На основе анализа современных мировых тенденций в развитии внешнеторговой деятельности предложить направления трансформации стратегического управления развитием экспортного потенциала агропромышленного комплекса региона в условиях неопределенности экономической ситуации в стране. Метод или методология проведения работы. В исследовании использованы общенаучные методы систематизации, индукции, анализа данных о развитии экспортного потенциала агропромышленного комплекса Ростовской области. Результаты. Обосновано, что внешнеторговая деятельность –важнейший стратегический приоритет развития субъектов РФ в условиях глобализации, развитие которой способствует общему социально-экономическому росту, стимулированию развития инновационной экономики. Региональный внешнеэкономический комплекс выступает, с одной стороны, как подсистема национальной внешнеэкономической системы. С другой стороны, он является подсистемой регионального территориального производственно-хозяйственного комплекса, который обеспечивает рост доли валового регионального продукта, обусловленной внешнеэкономическими связями субъекта Российской Федерации и хозяйствующих субъектов, которые находятся на его территории. Проведенный анализ показывает, что стратегическим направлением государственного регулирования развития экспортного потенциала РФ и ее регионов в современных условиях является поддержка экспорта, а также улучшение доступа на внешние рынки посредством субсидирования процентных ставок по экспортным кредитам и иным инструментам финансирования, аналогичным кредиту. Также актуальным направлением государственного регулирования формирования и развития экспортного потенциала российских регионов остается совершенствование торговых режимов с зарубежными партнерами, многостороннее сотрудничество и взаимодействие с международными организациями. Область применения результатов. Результаты проведенного исследования могут быть использованы при разработке стратегии развития экспортного потенциала регионов страны. Выводы. Повышение эффективности государственного управления обусловливает необходимость выявления стратегических направлений в развитии экономики российских регионов, что позволит обеспечить переход к динамичному экономическому росту на региональном уровне, в том числе за счет эффективного использования имеющегося и формируемого мерами государственной поддержки экспортного потенциала отраслей агропромышленного комплекса.
The Effect of Product Diversification on Corporate Social Performance in the Non-Renewable Energy Industry: Exploring the moderating effects of host country development and the Sustainable Development Goals
Authors: Jongsma Renske , Pennink Bart Jan (Bartjan) 
Published: December 2020

Aim: Building upon stakeholder and institutional theory, this paper investigates the relationship between product diversification and corporate social performance (CSP), thereby attempting to make essential contributions to the current literature. Based on an extensive literature review, it was expected that related, unrelated and total product diversification are positively related to CSP. Moreover, it was hypothesized that the exposure to weak institutional host country environments negatively affects the relationship between diversification and CSP, and that the Sustainable Development Goals (SDGs) have a positive effect on the relationship.
Design / Research methods: The sample selected for this research is the non-renewable energy industry, since the industry shows great divergence in terms of corporate social responsibility (CSR) performance. In addition, the industry is highly susceptible to regulatory changes, while the Sustainable Development Goals have an enormous focus on the reliability and sustainability of energy, making it a highly relevant industry to study. This study analyzed 40 a 40 non-renewable energy firms over a time frame of seven years, by using OLS regression.
Conclusions / findings: The results reveal that unrelated diversification is positively related to CSP, while the other forms of diversification show insignificant results. Contrary to expectations, the Sustainable Development Goals negatively affect the relationship between product diversification and CSP, while the moderating effect of exposure to weak institutional environments is insignificant.
Originality / value of the article: Research on the relationship between product diversification on corporate financial performance is well-established, but the way in which product diversification influences a firm’s behavior towards stakeholder demands and social concerns remains largely unexplored. Accordingly, the results of this study challenge existing theories while adding more context to the existing relationship, and in turn provide promising avenues for future research.
RENT EXTRACTION PADA PERUSAHAAN DENGAN STRUKTUR KEPEMILIKAN TERKONSENTRASI DI BURSA EFEK INDONESIA
Authors: Surasni Ni Ketut , Hermanto Hermanto , Hermanto Hermanto 
Published: December 2020

This study aims to examine the existence of rent extraction by examining the market reaction to the increase and decrease in dividends. For this purpose, the method used is an event study. Market reaction is measured using cumulative average abnormal return (CAAR). If CAAR is high> CAAR is low. hence rent extraction is proven, dividends are proven to relieve conflict between majority and minority. By using the difference test, it was not proven that high CAAR> low CAAR. These results indicate that investors do not react to increases or decreases in dividends. In companies with a concentrated ownership structure, dividends do not function as a reliever for conflicts between majority and minority. Kata kunci: Concentrated ownership structure, rent extraction, dividends.
PENERAPAN PENDEKATAN KONSTRUKTIVISME UNTUK MENINGKATKAN KEMAMPUAN PENALARAN MATEMATIS PESERTA DIDIK PADA MATERI STATISTIKA KELAS 12 SMA NEGERI 4 BOJONEGORO
Authors: Ilmiyah Nurul , Suyoto Suyoto 
Published: December 2020

Salah satu ciri matematika adalah menekankan pada proses deduktif aksiomatik yang memerlukan penalaran logis. Penalaran masuk dalam kompetensi dasar yang harus dikuasai siswa, sehingga diharapkan siswa dapat menganalisis suatu permasalahan sebelum mengambil suatu keputusan sebagai bekal untuk menghadapi tantangan perkembangan dan perubahan. Fakta menunjukkan bahwa kemampuan siswa dalam bernalar belum diperhatikan secara mendalam. Untuk itu diperlukan pembelajaran yang didesain menurut pandangan konstruktivisme karena menurut pandangan tersebut pembelajaran bertujuan untuk membantu peserta didik untuk membangun konsep-konsep/ prinsip-prinsp matematika dengan kemampuannya sendiri melalui asimilasi dan akomodasi.
Penelitian ini merupakan Penelitian Tindakan Kelas (PTK) dengan tujuan meningkatkan kemampuan penalaran matematika melalui pendekatan konstruktivisme. Subjek pada penelitian ini adalah peserta didik kelas XII IPA 2 SMA Negeri 4 Bojonegoro sebanyak 33 orang. Prosesur dalam penelitian ini meliputi perencanaan, pelaksanaan, observasi, dan refleksi. Perangkat pembelajaran dalam penelitian ini adalah Rencana Pelaksanaan Pembelajaran (RPP), bahan ajar, dan Lembar Kerja Peserta Didik (LKPD) sedangkan instumen penelitian yang digunakan adalah Tes Kemampuan Penalaran (TKP).
Dari hasil analisis data, dapat disimpulkan bahwa kemampuan penalaran matematis peserta didik kelas XII IPA 2 telah memenuhi indicator keberhasilan penelitian setelah siklus kedua, yaitu sebanyak 67% (24 peserta didik) memenuhi kriteria baik dalam bernalar. Keterlaksanaan pembelajaran tergolong baik pada siklus kedua yaitu seluruh pembelajaran terlaksana dengan prosentase 88,5%.
Meningkatkan Hasil Belajar Matematika Melalui Model Discovery Learning Pada Materi Limit Fungsi Aljabar Di Kelas XI SMA Darul Ulum 1 Peterongan
Authors: Perdana Rizkia Putri , Fauziyah Nur , Suyoto Suyoto 
Published: December 2020

Penelitian ini bertujuan untuk mengetahui: apakah penerapan Model Discovery Learning pada materi pokok limit fungsi aljabar dapat meningkatkan hasil belajar peserta didik kelas XI SMA Darul Ulum 1 Peterongan. Penelitian ini menggunakan Penelitian Tindakan Kelas (Classroom Action Research) pada peserta didik kelas XI IPA1 dengan jumlah peserta didik sebanyak 34 peserta didik. Metode pengumpulan data yang digunakan adalah documenter dan tes. Penelitian tindakan kelas ini dirancang dalam 2 (dua) siklus, setiap siklus ada 4 (empat) tahap yaitu perencanaan (planning), tindakan (action), Pengamatan(observation), dan refleksi (reflection
Dengan menerapkan model belajar Discovery Learning dalam pengajaran mata pelajaran Matematika diperoleh nilai rata–rata hasil pembelajaran yaitu sebelum siklus diperoleh nilai rata-rata sebanyak 58,24, pada siklus pertama sebanyak 69,9, dan pada siklus kedua sebanyak 84.01.
Dari data tersebut, dapat disimpulkan bahwa model pembelajaran Discovery Learning dengan melalui delapan langkah- langkahnya dapat meningkatkan hasil belajar peserta didik pada pokok pada materi pokok limit fungsi aljabar kelas XI SMA Darul Ulum 1 Peterongan. Keberhasilan penggunaan metode tersebut diharapkan bisa digunakan sebagai alternatif pendekatan pembelajaran yang inovatif. Selanjutnya para guru dapat lebih berkreasi dalam menggunakan model pembelajaran yang sesuai dengan tujuan pembelajaran.
PENERAPAN DISCOVERY LEARNING DENGAN STRATEGI REACT UNTUK MENINGKATKAN AKTIVITAS DAN HASIL BELAJAR PESERTA DIDIK KELAS XI-B SMA PLUS AR-RAHMAT BOJONEGORO MATERI POLINOMIAL
Authors: Saifurrisal Ahmad Hasan , Suyoto Suyoto , Uchtiawati Sri , Fauziyah Nur 
Published: December 2020

Hasil pengamatan yang dilakukan di kelas XI-B SMA Plus Ar-Rahmat Bojonegoro menunjukkan bahwa sebagian besar peserta didik mengalami kesulitan pada materi polinomial. Kesulitan yang dialami peserta didik diduga karena guru lebih sering mengajar dengan model pembelajaran ekspositori sehingga peserta didik kurang aktif dalam proses belajar mengajar dan menyebabkan hasil belajar peserta didik kurang maksimal. Maka, perlu diterapkan metode pembelajaran yang dapat meningkatkan aktivitas dan hasil belajar peserta didik, yaitu discovery learning dengan strategi REACT. Penelitian ini dilaksanakan dengan tujuan untuk mendeskripsikan langkah-langkah pembelajaran discovery learning dengan strategi REACT yang dapat meningkatkan aktivitas dan hasil belajar peserta didik kelas XI-B SMA Plus ArRahmat Bojonegoro materi polinomial.
Penelitian ini merupakan Penelitian Tindakan Kelas (PTK). Data penelitian berupa daftar nilai peserta didik pada tes di tiap akhir siklus dan data hasil observasi yang didapatkan dari observer. Pengumpulan data dilakukan dengan teknik observasi, angket, lembar penilaian aktivitas peserta didik, tes, catatan lapangan, dan dokumentasi. Data yang terkumpul dianalisis secara kualitatif dan kuantitatif.
Berdasarkan hasil analisis tersebut, diperoleh dua kesimpulan sebagai berikut. Pertama, bahwa penerapan discovery learning dengan strategi REACT pada materi polinomial yang dapat meningkatkan aktivitas dan hasil belajar peserta didik kelas XI-B SMA Plus Ar-Rahmat Bojonegoro memiliki langkah-langkah: 1) guru memberikan apersepsi dan motivasi; 2) menerapkan discovery learning dengan strategi REACT dengan tahapan: stimulation, problem statement, data collection, data processing, dan verification; 3) peserta didikmengomunikasikan hasil diskusi kelompok kemudian bersama-sama guru membuat kesimpulan. Kedua, bahwa pembelajaran dengan discovery learning dengan strategi REACT meningkatkan aktivitas dan hasil belajar peserta didikkelas XI-B SMA Plus Ar-Rahmat Bojonegoro. Skor rata-rata aktivitas peserta didik pada siklus I sebesar 27,5 dengan kategori baik, tetapi masih ada poin pengamatan yang bernilai 2. Skor rata-rata aktivitas peserta didik pada siklus II sebesar 35,5 dengan kategori sangat baik, dan setiap poin pengamatan mencapai minimal nilai 3. Hasil tes peserta didik pada siklus I menunjukkan bahwa 60% peserta didik yang memperoleh nilai mencapai KKM dengan rata-rata hasil tes yang diperoleh adalah sebesar 78,25. Hasil tes peserta didik pada siklus II menunjukkan bahwa 90% peserta didik yang memperoleh nilai mencapai KKM dengan rata-rata hasil tes yang diperoleh adalah sebesar 85,45.
СУТНІСНИЙ ЗМІСТ КОНКУРЕНТНИХ ПЕРЕВАГ У ДОСЯГНЕННІ СТРАТЕГІЧНИХ ЦІЛЕЙ
Authors: Шмалій Наталія Анатоліївна 
Published: December 2020

The article seeks to explore the contemporary issues of meaningful content of a competitive advantage in achieving strategic goals. The study offers an attempt to provide a deeper understanding of competitive advantage origin and generation and suggests two patterns: competitive advantage as an outcome of effective resource management and the performance efficiency (activity success) as an outcome of gaining a competitive advantage. The relationship between the organizational knowledge categories and enterprise strategy is presented. It is argued that innovative knowledge shapes a favourable environment for building competitive advantages. The literature review on modern approaches to building company competitive advantages has allowed identifying three main areas: market-based approach, resource-based approach and partnership-based approach. It is suggested to differentiate each of the above approaches to generating competitive advantages from the three basic perspectives: in terms of the source of competitive advantage, barriers to imitation of competitive advantages and from the position of the company strategic goals. A retrospective analysis of the meaningful content of a competitive advantage concept contributed to providing the author’s interpretation of this category with an emphasis on the relevance of its consideration within three projections – market position, unique resources / opportunities and partnership interaction with further focus on specific drivers of competitive advantages as an impetus for partnership collaboration in the business environment. Among the factors able to boost competitive advantages the study considers the following: innovative knowledge exchange possibilities and building the capacity to create additional resources / opportunities (tangible and intangible). A competitive advantage within the scope of this study is viewed as company's ability to respond quickly to market demands through the effective use of unique resources / opportunities (own and derived from partnerships in the current business environment) in order to most effectively meet the customer needs and expectations.
Benefit Cost Analysis of Small Farm Machineries Used for Rice Cultivation in Nepal
Authors: Acharya Prakash , Regmi Punya Prasad , Gauchan Devendra , KC Dilli Bahadur , KC Gopal Bahadur 
Published: December 2020

A study was conducted in Jhapa, Sunsari and Bardiya district of Nepal to assess the benefit cost (BCA) analysis of small farm machineries (transplanter, reaper and power tiller) used for rice cultivation. Out of total respondents of 274 under mechanized farm category selected using Raosoft Software of sample size determination, 74% reaper owner (20), 67% power tiller owner (20) and 100% transplanter owner (09) were selected for analyzing benefit cost analysis using simple random sampling. BCA analysis showed that the NPV, B/C ratio, IRR and Payback Period of investing in transplanter were NRs 452743.62, 1.61, 24% and 2.75 years at 12% discount rate respectively. Similarly, NPV, B/C ratio, IRR and Payback period for reaper and power tiller were NRs 422541.93, 2.89, 123% and 1.14 years and NRs 619,719.34, 2.32, 65% and 1.46 years at 12% of discount rate respectively. The investment on reaper and power tiller would be profitable for their higher Benefit Cost ratio and IRR, and lower payback period. The results of sensitivity analysis showed that investments in reaper and power tiller would be profitable even if decrease in benefit or increase in cost or decrease in benefit and increase in cost by 20% is considered. However, in case of transplanter, the IRR would be less than the discount rate when benefit decreases by 20% and cost increases by 20%. Due to high investment at the initial stage, the payback period was longer and IRR was also less than 30% per annum in transplanter which indicated that investment would not be made for transplanter unless price of transplanter is lowered through regulation of price and provision of subsidy. It is suggested to motivate farmers for adoption of small farm machineries in rice cultivation through provision of differentiated rates of subsidy and technical capacity build up.