bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with typical enteropathogenicEscherichia coliinfection among children <5 years old with moderate-to-severe diarrhoea in rural western Kenya, 2008–2012
Authors: Fagerli K. , Omore R. , Kim S. , Ochieng J. B. , Ayers T. L. , Juma J. , Farag T. H. , Nasrin D. , Panchalingam S. , Robins-Browne R. M. , Nataro J. P. , Kotloff K. L. , Levine M. M. , Oundo J. , Parsons M. B. , Laserson K. F. , Mintz E. D. , Breiman R. F. , O'Reilly C. E. 
Published: November 2020

AbstractTypical enteropathogenicEscherichia coli(tEPEC) infection is a major cause of diarrhoea and contributor to mortality in children <5 years old in developing countries. Data were analysed from the Global Enteric Multicenter Study examining children <5 years old seeking care for moderate-to-severe diarrhoea (MSD) in Kenya. Stool specimens were tested for enteric pathogens, including by multiplex polymerase chain reaction for gene targets of tEPEC. Demographic, clinical and anthropometric data were collected at enrolment and ~60-days later; multivariable logistic regressions were constructed. Of 1778 MSD cases enrolled from 2008 to 2012, 135 (7.6%) children tested positive for tEPEC. In a case-to-case comparison among MSD cases, tEPEC was independently associated with presentation at enrolment with a loss of skin turgor (adjusted odds ratio (aOR) 2.08, 95% confidence interval (CI) 1.37–3.17), and convulsions (aOR 2.83, 95% CI 1.12–7.14). At follow-up, infants with tEPEC compared to those without were associated with being underweight (OR 2.2, 95% CI 1.3–3.6) and wasted (OR 2.5, 95% CI 1.3–4.6). Among MSD cases, tEPEC was associated with mortality (aOR 2.85, 95% CI 1.47–5.55). This study suggests that tEPEC contributes to morbidity and mortality in children. Interventions aimed at defining and reducing the burden of tEPEC and its sequelae should be urgently investigated, prioritised and implemented.
Didactic education in paediatric cardiology during the COVID-19 pandemic: a national fellow survey
Authors: Ganigara Madhusudan , Sharma Chetan , Molina Berganza Fernando , Joshi Krittika , Blaufox Andrew D. , Hayes Denise A. 
Published: November 2020

AbstractThe coronavirus disease 2019 (COVID-19) pandemic has had a profound impact on medical educational curricula. We aimed to examine the impact of these unprecedented changes on the formal education of paediatric cardiology fellows through a nationwide survey. A REDCap™-based voluntary anonymous survey was sent to all current paediatric cardiology fellows in the United States of America in May, 2020. Of 143 respondents, 121 were categorical fellows, representing over one-fourth of all categorical paediatric cardiology fellows in the United States of America. Nearly all (140/143, 97.9%) respondents utilised online learning during the pandemic, with 134 (93.7%) reporting an increase in use compared to pre-pandemic. The percentage of respondents reporting curriculum supplementation with outside lectures increased from 11.9 to 88.8% during the pandemic. Respondents considered online learning to be “equally or more effective” than in-person lectures in convenience (133/142, 93.7%), improving fellow attendance (132/142, 93.0%), improving non-fellow attendance (126/143, 88.1%), and meeting individual learning needs (101/143, 70.6%). The pandemic positively affected the lecture curriculum of 83 respondents (58.0%), with 35 (24.5%) reporting no change and 25 (17.5%) reporting a negative effect. A positive effect was most noted by those whose programmes utilised supplemental outside lectures (62.2 versus 25.0%, p = 0.004) and those whose lecture frequency did not decrease (65.1 versus 5.9%, p < 0.001). Restrictions imposed by the COVID-19 pandemic have greatly increased utilisation of online learning platforms by medical training programmes. This survey reveals that an online lecture curriculum, despite inherent obstacles, offers advantages that may mitigate some negative consequences of the pandemic on fellowship education.
Profiling the Word Reading Abilities of School-Age Children with Neurofibromatosis Type 1
Authors: Arnold Shelley S. , Payne Jonathan M. , McArthur Genevieve , North Kathryn N. , Barton Belinda 
Published: November 2020

AbstractObjective:Reading difficulties are one of the most significant challenges for children with neurofibromatosis type 1 (NF1). The aims of this study were to identify and categorize the types of reading impairments experienced by children with NF1 and to establish predictors of poor reading in this population.Method:Children aged 7–12 years with NF1 (n = 60) were compared with typically developing children (n = 36). Poor word readers with NF1 were classified according to impairment type (i.e., phonological, surface, mixed), and their reading subskills were compared. A hierarchical multiple regression was conducted to identify predictors of word reading.Results:Compared to controls, children with NF1 demonstrated significantly poorer literacy abilities. Of the 49 children with NF1 classified as poor readers, 20 (41%) were classified with phonological dyslexia, 24 (49%) with mixed dyslexia, and 5 (10%) fell outside classification categories. Children with mixed dyslexia displayed the most severe reading impairments. Stronger working memory, better receptive language, and fewer inattentive behaviors predicted better word reading skills.Conclusions:The majority of children with NF1 experience deficits in key reading skills which are essential for them to become successful readers. Weaknesses in working memory, receptive language, and attention are associated with reading difficulties in children with NF1.
TRANSNATIONAL INTEREST CONVERGENCE AND GLOBAL KOREA AT THE EDGE OF RACE AND QUEER EXPERIENCES
Authors: Thomsen Patrick S. 
Published: November 2020

AbstractThis is a story about gay/queer globalization unfolded through the narratives of Korean gay men in Seoul. In this paper, I make use of talanoa dialogues to apprehend the way race and racial hierarchies can provide insights into the conditions in which the gay subject in Seoul is intelligible in intercultural interactions. I present these narratives in the format of a thematic talanoa using Pacific Research Methodologies (PRM). In doing so, I advance a unique way to negotiate communication with participants in a cross-cultural setting, rendering myself visible as a racialized (Sāmoan) researcher. Empirically, I argue that the narratives of Korean gay men party to this study demonstrate how the Korea/local–West/global binary is an important referential, in that there exists a structural connection through immigration policies that facilitates a transnational convergence of local and global racial hierarchies. This connection, I also argue, helps to structure and position Whiteness at the apex of racial hierarchies around foreigner subjectivities in South Korea.
Twins Living Apart: Behavioral Insights/Twin Study Reviews: Managing Monochorionic-Diamniotic Twin Pregnancies; Paternity Testing in Multiple Pregnancies; Twin Research on Resilience; Trisomies in Twin Pregnancies/Human Interest: Reunited Brazilian Twins; Website for Twins with Disabled Co-Twins; Twins Separated in Secret of the Nile Series; Mengele: Unmasking the Angel of Death; Twins Helping Others
Authors: Segal Nancy L. 
Published: November 2020

AbstractA brief review of research findings regarding twins living apart is presented. This review is followed by a look into the lives of a pair of monozygotic male twins who have lived in different continents for many years, but who stay closely connected. The reasons behind their decision and its impact on their behavioral resemblance and social relationship quality are examined. The next section summarizes recent studies that address the management of monochorionic-diamniotic twin pregnancies, paternity testing in multiple pregnancies, trisomies in twin pregnancies and the roots of resilience. The final portion of this article presents human-interest stories involving reunited Brazilian twins, a new resource for twins with disabled co-twins, twins separated in the Secret of the Nile television series, a new book about Dr Josef Mengele and his horrific twin experiments conducted at the Auschwitz–Birkenau concentration camp, and a pair of twins dedicated to helping others.
Comparison of Genome-Wide Association Scans for Quantitative and Observational Measures of Human Hair Curvature
Authors: Ho Yvonne Y. W. , Mina-Vargas Angela , Zhu Gu , Brims Mark , McNevin Dennis , Montgomery Grant W. , Martin Nicholas G. , Medland Sarah E. , Painter Jodie N. 
Published: November 2020

AbstractPrevious genetic studies on hair morphology focused on the overall morphology of the hair using data collected by self-report or researcher observation. Here, we present the first genome-wide association study (GWAS) of a micro-level quantitative measure of hair curvature. We compare these results to GWAS results obtained using a macro-level classification of observable hair curvature performed in the same sample of twins and siblings of European descent. Observational data were collected by trained observers, while quantitative data were acquired using an Optical Fibre Diameter Analyser (OFDA). The GWAS for both the observational and quantitative measures of hair curvature resulted in genome-wide significant signals at chromosome 1q21.3 close to the trichohyalin (TCHH) gene, previously shown to harbor variants associated with straight hair morphology in Europeans. All genetic variants reaching genome-wide significance for both GWAS (quantitative measure lead single-nucleotide polymorphism [SNP] rs12130862, p = 9.5 × 10–09; observational measure lead SNP rs11803731, p = 2.1 × 10–17) were in moderate to very high linkage disequilibrium (LD) with each other (minimum r2 = .45), indicating they represent the same genetic locus. Conditional analyses confirmed the presence of only one signal associated with each measure at this locus. Results from the quantitative measures reconfirmed the accuracy of observational measures.
Present‐Day Deformation Mechanism of the Northeastern Mina Deflection Revealed by the 2020 Mw 6.5 Monte Cristo Range Earthquake
Authors: Zheng Ao , Chen Xiaofei , Xu Wenbin 
Published: November 2020

AbstractThe 15 May 2020 Monte Cristo Range Mw 6.5 earthquake occurred in the northeast of the Mina deflection, which accommodates approximately a quarter of the relatively dextral motion between the Pacific and North American plates. The Monte Cristo Range event provides an opportunity to study the present‐day regional deformation mechanism and active tectonics. In this study, we investigate the source rupture process of the event using joint inversion of interferometric synthetic aperture radar and broadband seismic data. We find that the rupture propagates almost simultaneously on two main segments. The fault motion changes from the predominantly sinistral slip near the epicenter on the eastern segment to the oblique slip on the western segment, with a maximum coseismic slip of 0.8 m. Our results suggest that the accommodation of slip transfer localized in the northeastern Mina deflection tends to transform from the wrench‐ to extension‐dominated transtension.
Primary Joint Statistical Seismic Influence on Ionospheric Parameters Recorded by the CSES and DEMETER Satellites
Authors: Li Mei , Shen Xuhui , Parrot Michel , Zhang Xuemin , Zhang Yan , Yu Chen , Yan Rui , Liu Dapeng , Lu Hengxin , Guo Feng , Huang Jianping 
Published: November 2020

AbstractOppositely to a previous statistical work using a single time resolution of the total ion density measured onboard the Detection of Electro‐Magnetic Emissions Transmitted from Earthquake Regions (DEMETER) satellite, this work deals with statistical seismo‐ionospheric influences by comparing different parameters and various time resolutions. The O+ density and electron density recorded by the China Seismo‐Electromagnetic Satellite (CSES) for more than one year and by the DEMETER satellite for about 6.5 years have been utilized to globally search ionospheric perturbations with different time resolutions. A comparison is automatically done by software between the occurrence of these ionospheric perturbations determined by different data sets, and the occurrence of earthquakes under the conditions that these perturbations occur at less than 1,500 km and up to 15 days before the earthquakes. Combined with statistical results given by both satellites, it is shown that the detection rate r of earthquakes increases as the data time resolution and the earthquake magnitude increase and as the focal depth decreases. On average, the number of perturbations is higher the day of the earthquake, and then smoothly decreases the days before, which is independent of either ionospheric parameters or time resolutions. The number of right alarms is high near the South Atlantic Magnetic Anomaly area but its relationship with seismic activities is weak. The ion density tends to be more sensitive to seismic activities than the electron density but this needs further investigations. This study shows that the CSES could effectively register ionospheric perturbations due to strong EQs as the DEMETER satellite does.
Magnetic Anisotropy of Rocks: A New Classification of Inverse Magnetic Fabrics to Help Geological Interpretations
Authors: Černý J. , Melichar R. , Všianský D. , Drahokoupil J. 
Published: November 2020

AbstractInverse magnetic fabrics defined by anisotropy of magnetic susceptibility with the longest principal axis perpendicular to bedding were identified in the studied samples of Ordovician sedimentary rocks from the Barrandian area, Czech Republic. These fabrics are related to ankerite fibers in association with cone‐in‐cone structures. To understand the meaning of such inverse magnetic fabrics for geological interpretations, a new, more detailed classification of inverse magnetic fabrics' types is formulated in this paper. Distinguishing the structural (i.e., shape) and magnetocrystalline anisotropies in rocks, three new (sub)types of magnetic fabrics were defined in this study based on the combination of structural normal/inverse and magnetocrystalline normal/inverse anisotropies. As a result, normal magnetic fabric is extended by new fabric types associated with inverse anisotropy: simple inverse, pure inverse, and pseudo‐normal magnetic fabrics. The studied fibrous ankerite shows simple inverse magnetic fabric, which results from the combination of normal magnetocrystalline and inverse structural anisotropies.
Atlantic Meridional Overturning Circulation: Reviews of Observational and Modeling Advances—An Introduction
Authors: Srokosz Meric , Danabasoglu Gokhan , Patterson Michael 
Published: November 2020

AbstractThis article provides a brief overview of AMOC science organized collaboratively between the UK RAPID and US AMOC Programs (with partners internationally) during the past 16 years as reflected in the set of synthesis and review articles in the AGU special issue entitled “Atlantic Meridional Overturning Circulation: Reviews of Observational and Modeling Advances.” The article highlights the programs' initial motivations and summarizes the successful implementation of the pan‐Atlantic AMOC observing system, efforts to assess the state, variability, and changes in AMOC, advances in understanding AMOC variability mechanisms and predictability, and illumination of AMOC impacts on global and regional climate, sea level, and ecosystems.
Novel resonant pressure sensor based on piezoresistive detection and symmetrical in-plane mode vibration
Authors: Han Xiangguang , Mao Qi , Zhao Libo , Li Xuejiao , Wang Li , Yang Ping , Lu Dejiang , Wang Yonglu , Yan Xin , Wang Songli , Zhu Nan , Jiang Zhuangde 
Published: November 2020

AbstractIn this paper, a novel resonant pressure sensor is developed based on electrostatic excitation and piezoresistive detection. The measured pressure applied to the diaphragm will cause the resonant frequency shift of the resonator. The working mode stress–frequency theory of a double-ended tuning fork with an enhanced coupling beam is proposed, which is compatible with the simulation and experiment. A unique piezoresistive detection method based on small axially deformed beams with a resonant status is proposed, and other adjacent mode outputs are easily shielded. According to the structure design, high-vacuum wafer-level packaging with different doping in the anodic bonding interface is fabricated to ensure the high quality of the resonator. The pressure sensor chip is fabricated by dry/wet etching, high-temperature silicon bonding, ion implantation, and wafer-level anodic bonding. The results show that the fabricated sensor has a measuring sensitivity of ~19 Hz/kPa and a nonlinearity of 0.02% full scale in the pressure range of 0–200 kPa at a full temperature range of −40 to 80 °C. The sensor also shows a good quality factor >25,000, which demonstrates the good vacuum performance. Thus, the feasibility of the design is a commendable solution for high-accuracy pressure measurements.
Critical roles of FAM134B in ER-phagy and diseases
Authors: Mo Jie , Chen Jin , Zhang Bixiang 
Published: November 2020

AbstractFAM134B (also called JK-1, RETREG1), a member of the family with sequence similarity 134, was originally discovered as an oncogene in esophageal squamous cell carcinoma. However, its most famous function is that of an ER-phagy-regulating receptor. Over the decades, the powerful biological functions of FAM134B were gradually revealed. Overwhelming evidence indicates that its dysfunction is related to pathophysiological processes such as neuropathy, viral replication, inflammation, and cancer. This review describes the biological functions of FAM134B, focusing on its role in ER-phagy. In addition, we summarize the diseases in which it is involved and review the underlying mechanisms.
Regulation of p53 by the 14-3-3 protein interaction network: new opportunities for drug discovery in cancer
Authors: Falcicchio Marta , Ward Jake A. , Macip Salvador , Doveston Richard G. 
Published: November 2020

AbstractMost cancers evolve to disable the p53 pathway, a key tumour suppressor mechanism that prevents transformation and malignant cell growth. However, only ~50% exhibit inactivating mutations of p53, while in the rest its activity is suppressed by changes in the proteins that modulate the pathway. Therefore, restoring p53 activity in cells in which it is still wild type is a highly attractive therapeutic strategy that could be effective in many different cancer types. To this end, drugs can be used to stabilise p53 levels by modulating its regulatory pathways. However, despite the emergence of promising strategies, drug development has stalled in clinical trials. The need for alternative approaches has shifted the spotlight to the 14-3-3 family of proteins, which strongly influence p53 stability and transcriptional activity through direct and indirect interactions. Here, we present the first detailed review of how 14-3-3 proteins regulate p53, with special emphasis on the mechanisms involved in their binding to different members of the pathway. This information will be important to design new compounds that can reactivate p53 in cancer cells by influencing protein–protein interactions. The intricate relationship between the 14-3-3 isoforms and the p53 pathway suggests that many potential drug targets for p53 reactivation could be identified and exploited to design novel antineoplastic therapies with a wide range of applications.
A cellulose synthase-derived enzyme catalyses 3-O-glucuronosylation in saponin biosynthesis
Authors: Chung Soo Yeon , Seki Hikaru , Fujisawa Yukiko , Shimoda Yoshikazu , Hiraga Susumu , Nomura Yuhta , Saito Kazuki , Ishimoto Masao , Muranaka Toshiya 
Published: November 2020

AbstractTriterpenoid saponins are specialised metabolites distributed widely in the plant kingdom that consist of one or more sugar moieties attached to triterpenoid aglycones. Despite the widely accepted view that glycosylation is catalysed by UDP-dependent glycosyltransferase (UGT), the UGT which catalyses the transfer of the conserved glucuronic acid moiety at the C-3 position of glycyrrhizin and various soyasaponins has not been determined. Here, we report that a cellulose synthase superfamily-derived glycosyltransferase (CSyGT) catalyses 3-O-glucuronosylation of triterpenoid aglycones. Gene co-expression analyses of three legume species (Glycyrrhiza uralensis, Glycine max, and Lotus japonicus) reveal the involvement of CSyGTs in saponin biosynthesis, and we characterise CSyGTs in vivo using Saccharomyces cerevisiae. CSyGT mutants of L. japonicus do not accumulate soyasaponin, but the ectopic expression of endoplasmic reticulum membrane–localised CSyGTs in a L. japonicus mutant background successfully complement soyasaponin biosynthesis. Finally, we produced glycyrrhizin de novo in yeast, paving the way for sustainable production of high-value saponins.
Predictive design of sigma factor-specific promoters
Authors: Van Brempt Maarten , Clauwaert Jim , Mey Friederike , Stock Michiel , Maertens Jo , Waegeman Willem , De Mey Marjan 
Published: November 2020

AbstractTo engineer synthetic gene circuits, molecular building blocks are developed which can modulate gene expression without interference, mutually or with the host’s cell machinery. As the complexity of gene circuits increases, automated design tools and tailored building blocks to ensure perfect tuning of all components in the network are required. Despite the efforts to develop prediction tools that allow forward engineering of promoter transcription initiation frequency (TIF), such a tool is still lacking. Here, we use promoter libraries of E. coli sigma factor 70 (σ70)- and B. subtilis σB-, σF- and σW-dependent promoters to construct prediction models, capable of both predicting promoter TIF and orthogonality of the σ-specific promoters. This is achieved by training a convolutional neural network with high-throughput DNA sequencing data from fluorescence-activated cell sorted promoter libraries. This model functions as the base of the online promoter design tool (ProD), providing tailored promoters for tailored genetic systems.
Size-dependent strong metal-support interaction in TiO2 supported Au nanocatalysts
Authors: Du Xiaorui , Huang Yike , Pan Xiaoli , Han Bing , Su Yang , Jiang Qike , Li Mingrun , Tang Hailian , Li Gao , Qiao Botao 
Published: November 2020

AbstractThe strong metal-support interaction (SMSI) has long been studied in heterogonous catalysis on account of its importance in stabilizing active metals and tuning catalytic performance. As a dynamic process taking place at the metal-support interface, the SMSI is closely related to the metal surface properties which are usually affected by the size of metal nanoparticles (NPs). In this work we report the discovery of a size effect on classical SMSI in Au/TiO2 catalyst where larger Au particles are more prone to be encapsulated than smaller ones. A thermodynamic equilibrium model was established to describe this phenomenon. According to this finding, the catalytic performance of Au/TiO2 catalyst with uneven size distribution can be improved by selectively encapsulating the large Au NPs in a hydrogenation reaction. This work not only brings in-depth understanding of the SMSI phenomenon and its formation mechanism, but also provides an alternative approach to refine catalyst performance.