bluuebunny/crossref_metadata_2025_split huggingface dataset:
A PUF Hub Drives Self-Renewal inCaenorhabditis elegansGermline Stem Cells
Authors: Haupt Kimberly A , Law Kimberley T , Enright Amy L , Kanzler Charlotte R , Shin Heaji , Wickens Marvin , Kimble Judith 
Published: November 2019

AbstractThe Caenorhabditis elegans network for germline stem cells (GSCs) was missing key intrinsic regulators of self-renewal. Haupt et al. report that these missing regulators are PUF RNA-binding proteins, PUF-3 and PUF-11, which together with FBF-1 and FBF-2...Stem cell regulation relies on extrinsic signaling from a niche plus intrinsic factors that respond and drive self-renewal within stem cells. A priori, loss of niche signaling and loss of the intrinsic self-renewal factors might be expected to have equivalent stem cell defects. Yet this simple prediction has not been borne out for most stem cells, including Caenorhabditis elegans germline stem cells (GSCs). The central regulators of C. elegans GSCs include extrinsically acting GLP-1/Notch signaling from the niche; intrinsically acting RNA-binding proteins in the PUF family, termed FBF-1 and FBF-2 (collectively FBF); and intrinsically acting PUF partner proteins that are direct Notch targets. Abrogation of either GLP-1/Notch signaling or its targets yields an earlier and more severe GSC defect than loss of FBF-1 and FBF-2, suggesting that additional intrinsic regulators must exist. Here, we report that those missing regulators are two additional PUF proteins, PUF-3 and PUF-11. Remarkably, an fbf-1 fbf-2; puf-3 puf-11 quadruple null mutant has a GSC defect virtually identical to that of a glp-1/Notch null mutant. PUF-3 and PUF-11 both affect GSC maintenance, both are expressed in GSCs, and epistasis experiments place them at the same position as FBF within the network. Therefore, action of PUF-3 and PUF-11 explains the milder GSC defect in fbf-1 fbf-2 mutants. We conclude that a “PUF hub,” comprising four PUF proteins and two PUF partners, constitutes the intrinsic self-renewal node of the C. elegans GSC RNA regulatory network. Discovery of this hub underscores the significance of PUF RNA-binding proteins as key regulators of stem cell maintenance.
“Your Head so Dear to my Heart, I Would Hug Tight to My Chest and I would Tell How Much I Love You”. Letters of Jozefina Hálkova to Czesław Jankowski from 1884
Authors: Fedorovič Irena 
Published: November 2019

The aim of the article is to analyze the three letters written in Czech in 1884 and addressed to Polish poet, writer, literature critic, and translator Czesław Jankowski (1857–1929). The author of the letters is a previously unknown Czech woman, the daughter of a schoolteacher in the city of Kladno. She got acquainted with Cz. Jankowski in Krakow and became the object of his passion. The letters are stored in the Wroblewski Library of the Lithuanian Academy of Sciences in Vilnius. Although the author of this article has already mentioned the existence of these love letters in 2000, J. Hálkova’s letters to Cz. Jankowski have not yet been analyzed.
Pengaruh Lantunan Ayat Al-Quran terhadap Kebutuhan Opioid Tambahan Pascaseksio Sesarea
Authors: Winasty Silvi , Indriasari Indriasari , Kestriani Nurita Dian 
Published: November 2019

Lantunan ayat Al-Quran dapat menstimulasi β endorfin yang dihasilkan hipofisis anterior otak. Penelitian ini bertujuan mengetahui pengaruh lantunan ayat Al-Quran terhadap intensitas nyeri dan kebutuhan opioid tambahan pascaseksio sesarea dengan regional spinal. Metode penelitian adalah eksperimental secara acak terkontrol buta tunggal pada 32 ibu hamil berusia >18 tahun dan beragama islam di RSUP Dr. Hasan Sadikin Bandung pada bulan April–Mei 2019. Data jumlah penggunaan opioid tambahan pascaoperasi selama 24 jam yang diberikan dengan patient controlled analgesia (PCA) dianalisis dengan Uji Mann-Whitney. Hasil perhitungan statistik diperoleh penggunaan opioid tambahan pada kelompok lantunan Al-Quran lebih sedikit dibanding dengan kelompok kontrol (21,87 mcg vs 107,87 mcg) dengan perbedaan yang sangat bermakna (p<0,0001). Simpulan penelitian ini menunjukkan bahwa lantunan ayat Al-Quran sebagai terapi tambahan penatalaksanaan nyeri pascaseksio sesarea menurunkan penggunaan opioid tambahan.Effect of Quran Recital on Additional Opioid Requirement in Post-Cesarean SectionThe recitation of Al-Quran could stimulate β endorfins which is produced by anterior pituitary. This study aimed to identify the effect of listening to Al-Quran recitation on pain intensity and additional opioid requirement in patients after spinal cesarean section surgery. This was a randomized single blind controlled experiment on 32 pregnant moslem women over 18 years old treated in Dr. Hasan Sadikin General Hospital Bandung in April 2019-May 2019. The amount of additional 24-hours post-operative opioid requirement using Patient Controlled Analgesia (PCA) was analyzed by the Mann-Whitney Test. Results showed that the use of additional fentanyl in the Al-Quran recitation group was significantly less than in the controlled group(21.87 mcg vs 107.87 mcg) (p<0.0001). Therefore, Al-Quran recitation as an additional therapy in the management of pain is able to reduce the dose of additional fentamyl needed in postcaesarean section patients.
Laporan Kasus: Anestesi Blok Peribulbar pada Pasien dengan Gagal Jantung Kongestif yang Dilakukan Enukleasi
Authors: Adli Muhamad , Wullur Caroline 
Published: November 2019

Seorang pria berusia 73 tahun datang ke Instalasi Gawat Darurat Pusat Mata Nasional Rumah Sakit Mata Cicendo pada bulan November 2018 dengan keluhan nyeri mata yang mengeluarkan darah dan disertai dengan keluhan sesak. Pemeriksaan mata menunjukkan prolaps okuli dan direncanakan untuk dilakukan enukleasi. Ahli kardiologi mendiagnosis sebagai hypertensive heart disease, congestive heart failure functional class IV, moderate mitral regurgitation, moderate aortic regurgitation. Laporan kasus ini bertujuan memaparkan keberhasilan tata laksana anestesi pada pasien usia lanjut dengan gagal jantung kongestif yang dilakukan enukleasi dalam blok peribulbar. Teknik blok peribulbar dipilih agar tidak memperberat masalah kardiovaskular serta untuk meminimalisir depresi kardiak. Teknik ini dilakukan dengan menyuntikkan obat anestesi lokal levobupivakain 0,5% pada inferotemporal, medial kantus, dan superonasal. Operasi berlangsung tanpa keluhan nyeri dan fluktuasi hemodinamik yang signifikan. Pascaoperasi pasien sadar penuh dengan skala nyeri NRS 60 menit pascaoperasi 0. Hal ini menunjukkan bahwa teknik anestesi blok peribulbar memberikan hasil memuaskan pada tindakan enukleasi. Enucleation under Peribulbar Block Anesthesia in Patients with Congestive Heart Failure: A Case ReportA 73-year-old male patient was presented to the emergency department of the National Eye Center Cicendo Hospital with a painful and bloody eye as well as shortness of breath. Eye examination revealed ocular prolapse and patient was scheduled for enucleation. The cardiologist diagnosed the patient with hypertensive heart disease, congestive heart failure functional class IV, moderate mitral regurgitation, and moderate aortic regurgitation. Patient then underwent treatment for six days. This case report aimed to describe the successful management of anesthesia in elderly patients with congestive heart failure who underwent peribulbar block for enucleation procedure. To prevent further cardiac problems and to minimize the risk of cardiac depression in this patient, the anesthetic technique chosen was peribulbar block with the injection of local anesthetic drug levobupivacaine 0.5% at the inferotemporal, medial canthus, and superonasal. The surgary took place without complaints of intraoperative pain and without significant hemodynamic fluctuations. Postoperatively, the patient was fully conscious and sixty minutes postoperative pain scale (Numeric Rating Scale) in this patient was 0. This shows that the peribulbar block anesthesia technique can provide satisfactory results for enucleation procedure.
Conhecimento e atuação dos profissionais da farmácia sobre a dispensação dos medicamentos
Authors: Freire Izaura Luzia Silvério , Santos Fernanda Rafaela dos , Barbosa Juliana Dos Santos , Silva Bárbara Coeli Oliveira da , Silva Iago Souza da , Freitas Anna Alice Lessa de 
Published: November 2019

Introdução: A dispensação de medicamentos corresponde a entrega de medicação ao paciente, mediante solicitação por meio da prescrição. Uma dispensação adequada colabora com a segurança na terapia medicamentosa. Objetivo: Descrever o conhecimento e a atuação dos profissionais da farmácia sobre a dispensação dos medicamentos. Métodos: Trata-se de estudo exploratório-descritivo, transversal e quantitativo, realizado em uma maternidade escola na Região Nordeste do Brasil, com 25 profissionais da farmácia. Resultados: A maioria dos participantes informou que a farmácia estudada utiliza o sistema misto de distribuição dos medicamentos (96,0%), não possui programa informatizado para a dispensação de medicamentos (52,0%), o ambiente de trabalho se encontra inadequado (84,0%), presenciaram (68,0%) ou cometeram (52,0%) erros relativos a dispensação, nunca realizam a dupla checagem (72,0%), sempre identificam e diferenciam o estoque de medicamentos potencialmente perigosos dos demais (80,0%), nunca utilizam fontes de distrações durante a análise e dispensação dos medicamentos (56,0%) e algumas vezes dispensam medicamentos por ordem verbal (60,0%). Conclusão: Verificou-se a necessidade de se modificar a prática da farmácia estudada por meio de educação permanente e implementação de estratégias que minimizem a ocorrência de erros.
Palavras-Chave: Conhecimento; Preparações Farmacêuticas; Farmácia.
Shallow Structure of the Longmen Shan Fault Zone from a High-Density, Short-Period Seismic Array
Authors: Zhang Yuting , Li Hongyi , Huang Yafen , Liu Min , Guan Yong , Su Jinrong , Wang Tongli 
Published: November 2019

ABSTRACTThe Longmen Shan fault zone that was shocked by the 12 May 2008 M 8.0 Wenchuan earthquake acts as the boundary between the western edge of the Sichuan basin and the steep eastern margin of the Songpan-Ganze block. In this study, continuous seismic data recorded by 176 temporary short-period seismic stations between 22 October and 20 November 2017 are used to study the shallow crustal structure of the Longmen Shan fault zone by applying ambient-noise tomography and horizontal-to-vertical spectral ratio (HVSR) analysis. From ambient-noise analysis, fundamental-mode Rayleigh-wave dispersion curves between 0.25 and 1 Hz are extracted. Then, the direct surface-wave tomographic method is used to invert surface-wave dispersion data for the 3D shallow shear-wave velocity structure. Our results show that low shear-wave velocities are mainly distributed around the surface rupture trace of the Wenchuan earthquake at least down to 2 km. From the HVSR method, the sites are sorted into two types according to the pattern of HVSR curves with single peak or double peak. By converting frequency to depth, the results show that the sediments are thicker near the surface rupture. The low-velocity zone based on ambient-noise tomography agrees well with the distribution of sedimentary cover estimated from HVSR, which are generally consistent with geological information. Our results provide high-resolution shallow crustal velocity structure for future detailed studies of the Longmen Shan fault.
Uwarunkowania i trudności kształcenia zawodowego więźniów w Polsce
Authors: Mydłowska Beata 
Published: November 2019

Niniejszy artykuł dotyczy uwarunkowań i trudności kształcenia zawodowego osób osadzonych/więźniów w Polsce. Skoncentrowano się na takich kwestiach, jak uwarunkowania kształcenia zawodowego, podstawy prawne kształcenia zawodowego więźniów, możliwości kształcenia zawodowego przewidziane dla więźniów, a także warunki kształcenia zawodowego przewidziane dla więźniów oraz trudności w kształceniu zawodowym więźniów. Kształcenie zawodowe osób osadzonych jest w Polsce niezwykle ważną kwestią, dotyczącą zagadnienia ogólnego kształcenia zawodowego. Wsparcie w pozytywnej readaptacji zawodowej osób osadzonych to istotny temat, który skłania do dyskusji społecznej, czy na pewno w tym zakresie nie ma żadnych trudności, na które mogą natrafić więźniowie. Wszystkie organizacje, które świadczą pomoc w kwestii osób wykluczonych społecznie (także tych zagrożonych), czyli również osób osadzonych, wykonują wiele zadań, które mają na celu wsparcie tych osób w odniesieniu sukcesu w obszarze zawodowym. Cały ogólny system pomocy więźniom tworzą: kuratorzy, Służba Więzienna, różne instytucje pomocy społecznej.
Wykluczenie społeczne przestępców standardem kulturowo-normatywnym zdehumanizowanej władzy karania
Authors: Bałandynowicz Andrzej 
Published: November 2019

Proces obiektywnego wykreślania znaczenia pojęć-symboli odgrywa istotną rolę w edukacji, uczeniu, wychowaniu i powszechnej socjalizacji człowieka. Jest terenem zmagań transkulturowych, które powinny zmierzać do obnażenia całkowitej prawdy o człowieku, rozpoznawania jego miejsca w historii świata. Świadome wybory, oparte na wolnej woli i wolności wewnętrznej, pozwalają osobie eliminować socjalizację i wychowanie opierające się na założeniach postantropologicznych, a rozwijać dialog wewnętrzny sublimujący dynamizmy rozwojowe. Przedstawiciele instytucjonalnego porządku kulturowego, interpretując fakty i zjawiska społeczne, w tym przykładowo organizując proces sprawiedliwości karzącej wobec wykluczonych jako sprawców zachowań degeneratywnych, dopuszczają się świadomego wyboru wartości, norm i zasad postępowania oraz systemów odpowiedzialności penalnej dla wszystkich osób wchodzących w konflikt z prawem karnym. Minimalizowanie izolacji wewnętrznej w celu zracjonalizowania karania w stronę cywilizacyjno-kulturowych rozwiązań powinno odbywać się nie przez mechaniczne i symplicystyczne narzucanie wzorów, ale poprzez rzeczowe powiększanie zakresu samokontroli zachowania się skazanych wobec innych osób oraz zachowania się w grupach.
Assessment and selection of source material for creating melon hybrids with integrated resistance to anthracnose and powdery mildew
Authors: Varivoda Olga P. , Maslennikova Ekaterina S. 
Published: November 2019

Relevance. Melon as melon culture is cultivated in many countries of the world and is highly valued for its nutritional and dietary qualities. However, exposure to fungal diseases dramatically reduces the yield and taste of melons. Melon is affected mainly by powdery mildew and Anthracnose. In the conditions of the Bykovskaya melon breeding experimental station, the predominant type of powdery mildew is Sphaerotheca fuliginea. Evaluation and selection of the starting material with the identification of samples with complex resistance to these diseases is an important direction in the selection process, allowing to solve the problem of improving production efficiency and product quality.Methods. The aim of this work is to obtain melon varieties and hybrids with complex resistance to powdery mildew and Anthracnose. Complex stability was determined by artificial infection of melon plants in the phase of 2-3 real leaves by conventional methods.Results. 8 varieties and 10 F 1 hybrids of melon were studied for complex resistance to artificial Anthracnose and powdery mildew infection. Standard grade melon autumn was amazed powdery mildew of 81.2% with score lesion of 1.8 by Anthracnose, respectively, 93.8 per cent if the score is 2.3. The resulting hybrids were superior in stability to the standard. Hybrid x Ethiopian Farmer was amazed powdery mildew on 44% with score of 1.4. The prevalence of hybrid Original x Autumn was 54.4% powdery mildew with a score of 1.4, Anthracnose – 75% with a score of 1.8 (average for three years). The hybrid is fulfilled on economically valuable signs, has stable productivity of 17.5 t/ha, the content of dry substances in fruit juice to 17.2%. The samples and promising hybrids obtained with complex stability will be used in further breeding work.
The results of the comparative evaluation of samples of oat (<i>A. sativa</i> L., <i>A. byzantine</i> C. Koch) for resistance to lodging, yield and adaptability in central Non-chernozem zone of the Russian Federation
Authors: Vargach Julia I. 
Published: November 2019

Relevance. Each sample is characterized by a number of biological features, due to the recombination of genetic material in the process of its selection. These features are manifested in the reaction of plants to soil-climatic and technological conditions, expressed in the change of the elements of the yield structure and indicators of the level of adaptability of plants to growing conditions, as well as resistance to lodging. New samples have little-known properties that need to be studied and compared in specific soil and climatic conditions, to assess them in order to decide on the possibility of their zoning or culling. The main indicators characterizing the level of agricultural production are productivity, resistance to lodging, since the shortage of grain as a result of lodging of cereals can reach 15-40%. The introduction of new high-yielding varieties on the basis of their testing and the use of the most effective technological methods of cultivation on crops will allow to receive a significant gross harvest.Materials and methods. The study was carried out in 2016-2018 to assess models of cultural hexaploid species of oats hulled and naked forms of resistance to lodging, yield and adaptability in the temperate continental climate of Central non-Chernozem zone. Resistance to lodging, yield variability, indices of environmental conditions and adaptability were determined. The main method of evaluation of the field resistance to lodging – visual (in points) that allows you to rank the varieties based on this characteristic. We were calculated potential productivity and adaptability of varieties by method L. A. Zhivotkov et al. [1], an indicator of the stability level of the sample yield (Puss) by the method of E. D. Nettevich et al. [2].Results. Many varieties showed good plasticity and high productivity potential. The best in resistance to lodging, yield and adaptability among the hulled forms were varieties Sig, Mirt, Poseidon, Belinda, Rajtar, and the naked forms – Becas, Vyatsky, Korolek.
New varieties of vegetable cowpea (<i>Vigna unguiculata</i> subsp. <i>sesquipedalis </i>(L.) Verdc.) and prospects of their cultivation in southern Russia
Authors: Burlyaeva Marina O. , Gurkina Mariya V. , Chebukin Pavel A. , Perchuk Irina N. , Miroshnichenko Elena V. 
Published: November 2019

Relevance. Currently, there is an interest in this country in vegetable varieties of Vigna unguiculata subsp. sesquipedalis (L.) Verdc. However, a small number of varieties adapted to different cultivation conditions prevents a wider distribution of this crop. The present work was aimed at creating new vegetable cowpea varieties adapted to the climatic conditions of southern regions of Russia.Materials and methods. The study was carried out in 1998-2018 in the Astrakhan Province (Astrakhan Experiment Station) and in 2012-2018 in Primorsky Territory (Far East Experiment Station). Vegetable cowpea accessions from the global VIR collection were studied.Results. Many years of breeding have resulted in creation of such varieties as ‘Astrakhanskaya krasavitsa’, ‘Kaspiyskaya zarya’, ‘Zhemchyuzhina Kaspiya’ and ‘Lyanchihe’, which were included in the State Register of Breeding Achievements in 2019. All varieties are characterized by earliness, high productivity, excellent quality of vegetable pods, high protein content in pods in the technical ripeness phase (29.5-33.5%), and by low demand to the soil fertility. ‘Zhemchyuzhina Kaspiya’, ‘Astrakhanskaya krasavitsa’ and ‘Kaspiyskaya zarya’ are tolerant to high temperatures, air drought and soil salinity. The growing season for these varieties lasts 62-68 days in the Astrakhan Province under irrigation, while technical ripeness of pods occurs in 46-50 days. The green pod yield is 16.1–28.2 t/ha and the seed yield is 1.91-2.71 t/ha. The ‘Lyanchihe’ variety tolerates humidity well; its growing season in southern Primorsky Territory is 97-110 days, and pods reach technical ripeness in 61-70 days. The green pod yield is 21.0-24.0 t/ha, and that of seeds is 2.38-2.64 t/ha. The released varieties will broaden the range of vegetable crops cultivated in this country and improve the quality of nutrition of the population.
Yield of cabbage depending on the irrigation regime in the foothill subprovince of Dagestan
Authors: Hasayeva Zarema M. 
Published: November 2019

Relevance. The main producers of cabbage in Dagestan are personal subsidiary farms of the Mountain subprovince. An additional reserve of production is the Foothill subprovince (in particular buinak district), soil and climatic conditions which are favorable for growing cabbage. In this regard, studies aimed at studying the adaptive potential of cabbage varieties in this subprovince are relevant.Material and methods. The aim of the work is to develop elements of technology for growing varieties of cabbage in relation to the Foothill sub-province of the Republic of Dagestan. The results of three-year studies on the adaptive potential of cabbage varieties in irrigation conditions of the Foothill sub-province of the Republic of Dagestan are presented.Results. As a result of the conducted researches it is revealed that the variety Nadezhda has formed the greatest productivity on all variants on a mode of irrigation. Quite high data are also noted in the variety Samur 2. Comparative analysis of variants of the experiment the total water consumption showed that, on average, for the studied varieties of cabbage most economical use observed in the irrigation regime providing for irrigation when pre-irrigation moisture threshold 75-85-75% NV. On average, the studied varieties and hybrids of cabbage, the most economical expenditure was observed in the irrigation regime, which provides for the appointment of watering at the pre-watering threshold 7585-75% NV. Compared with the first option (70-80-70% NV) saving irrigation water was 150 m3/ha, and compared with the third option (80-90-80% NV) – 178 m3/ha. On the same option was formed quite high productivity of varieties of cabbage.