bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation and Resolution of Interference in the LC–QTOF-MS Detection of 4-MePPP
Authors: Allen Darren R , Warnholtz Christopher , McWhinney Brett C 
Published: January 2021

Abstract
An interference resulting in the false-positive detection of the synthetic cathinone 4ʹ-methyl-α-pyrrolidinopropiophenone (4-MePPP) in urine was suspected following the recent addition of 4-MePPP spectral data to a liquid chromatography–quadrupole time-of-flightmass spectrometry drug library. Although positive detection criteria were achieved, it was noted that all urine samples suspected of containing 4-MePPP also concurrently contained high levels of tramadol and its associated metabolites. Using quadrupole time-of-flightmass spectrometry software elucidation tools, candidate compounds for the suspected interference were proposed. To provide further confidence in the identity of the interference, in silico fragmentation tools were used to match product ions generated in the analysis with product ions predicted from the theoretical fragmentation of candidate compounds. The ability of the suspected interference to subsequently produce the required product ions for spectral library identification of 4-MePPP was also tested. This information was used to provide a high preliminary confidence in the compound identity prior to purchase and subsequent confirmation with certified reference material. A co-eluting isobaric interference was identified and confirmed as an in-source fragment of the tramadol metabolite, N,N-bisdesmethyltramadol. Proposed resolutions for this interference are also described and subsequently validated by retrospective interrogation of previous cases of suspected interference.
The effect of magnetic fields on properties of the circumgalactic medium
Authors: van de Voort Freeke , Bieri Rebekka , Pakmor Rüdiger , Gómez Facundo A , Grand Robert J J , Marinacci Federico 
Published: January 2021

ABSTRACT
We study the effect of magnetic fields on a simulated galaxy and its surrounding gaseous halo, or circumgalactic medium (CGM), within cosmological ‘zoom-in’ simulations of a Milky Way-mass galaxy as part of the Simulating the Universe with Refined Galaxy Environments (SURGE) project. We use three different galaxy formation models, each with and without magnetic fields, and include additional spatial refinement in the CGM to improve its resolution. The central galaxy’s star formation rate and stellar mass are not strongly affected by the presence of magnetic fields, but the galaxy is more disc dominated and its central black hole is more massive when B &gt; 0. The physical properties of the CGM change significantly. With magnetic fields, the circumgalactic gas flows are slower, the atomic hydrogen-dominated extended discs around the galaxy are more massive and the densities in the inner CGM are therefore higher, the temperatures in the outer CGM are higher, and the pressure in the halo is higher and smoother. The total gas fraction and metal mass fraction in the halo are also higher when magnetic fields are included, because less gas escapes the halo. Additionally, we find that the CGM properties depend on azimuthal angle and that magnetic fields reduce the scatter in radial velocity, whilst enhancing the scatter in metallicity at fixed azimuthal angle. The metals are thus less well-mixed throughout the halo, resulting in more metal-poor halo gas. These results together show that magnetic fields in the CGM change the flow of gas in galaxy haloes, making it more difficult for metal-rich outflows to mix with the metal-poor CGM and to escape the halo, and therefore should be included in simulations of galaxy formation.
Vector modes in ΛCDM: the gravitomagnetic potential in dark matter haloes from relativistic N-body simulations
Authors: Barrera-Hinojosa Cristian , Li Baojiu , Bruni Marco , He Jian-hua 
Published: January 2021

Abstract
We investigate the transverse modes of the gravitational and velocity fields in ΛCDM, based on a high-resolution simulation performed using the adaptive-mesh refinement general-relativistic N-body code gramses. We study the generation of vorticity in the dark matter velocity field at low redshift, providing fits to the shape and evolution of its power spectrum over a range of scales. By analysing the gravitomagnetic vector potential, which is absent in Newtonian simulations, in dark matter haloes with masses ranging from ∼1012.5 h−1M⊙ to ∼1015 h−1M⊙, we find that its magnitude correlates with the halo mass, peaking in the inner regions. Nevertheless, on average, its ratio against the scalar gravitational potential remains fairly constant, below percent level, decreasing roughly linearly with redshift and showing a weak dependence on halo mass. Furthermore, we show that the gravitomagnetic acceleration in haloes peaks towards the core and reaches almost 10−10 h cm/s2 in the most massive halo of the simulation. However, regardless of the halo mass, the ratio between the gravitomagnetic force and the standard gravitational force is typically at around the 10−5 level inside the haloes, again without significant radius dependence. This result confirms that the gravitomagnetic effects have negligible impact on structure formation, even for the most massive structures, although its behaviour in low density regions remains to be explored. Likewise, the impact on observations remains to be understood in the future.
SatGen: a semi-analytical satellite galaxy generator – I. The model and its application to Local-Group satellite statistics
Authors: Jiang Fangzhou , Dekel Avishai , Freundlich Jonathan , van den Bosch Frank C , Green Sheridan B , Hopkins Philip F , Benson Andrew , Du Xiaolong 
Published: January 2021

ABSTRACT
We present a semi-analytical model of satellite galaxies, SatGen, which can generate large statistical samples of satellite populations for a host halo of desired mass, redshift, and assembly history. The model combines dark matter (DM) halo merger trees, empirical relations for the galaxy–halo connection, and analytical prescriptions for tidal effects, dynamical friction, and ram-pressure stripping. SatGen emulates cosmological zoom-in hydrosimulations in certain aspects. Satellites can reside in cored or cuspy DM subhaloes, depending on the halo response to baryonic physics that can be formulated from hydrosimulations and physical modelling. The subhalo profile and the stellar mass and size of a satellite evolve depending on its tidal mass-loss and initial structure. The host galaxy can include a baryonic disc and a stellar bulge, each described by a density profile that allows analytic satellite orbit integration. SatGen complements simulations by propagating the effect of halo response found in simulated field galaxies to satellites (not properly resolved in simulations) and outperforms simulations by sampling the halo-to-halo variance of satellite statistics and overcoming artificial disruption due to insufficient resolution. As a first application, we use the model to study satellites of Milky Way (MW)- and M31-sized hosts, making it emulate simulations of bursty star formation and of smooth star formation, respectively, and to experiment with a disc potential in the host halo. We find that our model reproduces the observed satellite statistics reasonably well. Different physical recipes make a difference in satellite abundance and spatial distribution at the 25 per cent level, not large enough to be distinguished by current observations given the halo-to-halo variance. The MW/M31 disc depletes satellites by ${\sim } 20{{\ \rm per\ cent}}$ and has a subtle effect of diversifying the internal structure of satellites, which is important for alleviating certain small-scale problems. We discuss the conditions for a massive satellite to survive in MW/M31.
Machine Learning the Cosmic Curvature in a Model-independent Way
Authors: Wang Guo-Jian , Ma Xiao-Jiao , Xia Jun-Qing 
Published: January 2021

Abstract
In this work, we achieve the determination of the cosmic curvature ΩK in a cosmological model-independent way, by using the Hubble parameter measurements H(z) and type Ia supernovae (SNe Ia). In our analysis, two nonlinear interpolating tools are used to reconstruct the Hubble parameter, one is the Artificial Neural Network (ANN) method, and the other is the Gaussian process (GP) method. We find that ΩK based on the GP method can be greatly influenced by the prior of H0, while the ANN method can overcome this. Therefore, the ANN method may have more advantages than GP in the measurement of the cosmic curvature. Based on the ANN method, we find a spatially open universe is preferred by the current H(z) and SNe Ia data, and the difference between our result and the value inferred from Planck CMB is 1.6σ. In order to test the reliability of the ANN method, and the potentiality of the future gravitational waves (GW) standard sirens in the measurement of the cosmic curvature, we constrain ΩK using the simulated Hubble parameter and GW standard sirens in a model-independent way. We find that the ANN method is reliable and unbiased, and the error of ΩK is ∼0.186 when 100 GW events with electromagnetic counterparts are detected, which is $\sim 56\%$ smaller than that constrained from the Pantheon SNe Ia. Therefore, the data-driven method based on ANN has potential in the measurement of the cosmic curvature.
Pregnancy outcomes following maternal treatment with rituximab prior to or during pregnancy: a case series
Authors: Perrotta Kirstie , Kiernan Elizabeth , Bandoli Gretchen , Manaster Rachel , Chambers Christina 
Published: January 2021

Abstract

Objective
Rituximab is a CD20-directed cytolytic antibody used for non-Hodgkin lymphoma, chronic lymphocytic leukaemia and RA, and off label for JIA, multiple sclerosis and lupus. Owing to concerns about infant B cell depletion, the manufacturer recommends avoidance of rituximab throughout pregnancy and for 12 months before conception. The aim of this study was to add to the limited data on pregnancy outcomes in women with exposure to rituximab.

Methods
Data were obtained from MotherToBaby Pregnancy Studies. Participants were enrolled prospectively into this observational study between 2007 and 2019. Pregnancy exposure and outcome data were collected from medical records, telephone interviews and dysmorphology examinations. The outcomes examined included spontaneous abortion, stillbirth, premature delivery, pregnancy complications, major and minor anomalies, small for gestational age, neonatal complications and serious infections.

Results
We classified 19 women with exposure to rituximab into three groups. Group A included three women who received rituximab during pregnancy. Group B included three women who received their last infusion before conception but had assumed pregnancy exposure owing to the long half-life of the drug. Group C included 13 women who used rituximab in the 2 years before pregnancy, with the last infusion given no sooner than five half-lives before conception. Three children had a major structural defect. Preterm delivery occurred in two pregnancies, and two infants were small for gestational age on birth weight. No cases of B cell depletion were reported.

Conclusion
No pattern of major structural anomalies or other adverse outcomes was reported in this case series.
Effect of silage source, physically effective neutral detergent fiber, and undigested neutral detergent fiber concentrations on performance and carcass characteristics of finishing steers
Authors: Pereira Murillo C S , Yang Wenzhu Z , Beauchemin Karen A , McAllister Tim A , Wood Katharine M , Penner Gregory B 
Published: January 2021

Abstract
This study was designed to evaluate the effect of silage source (barley vs. wheat silage) when harvested at two chop lengths (low vs. high physically effective neutral detergent fiber [peNDF]) and when barley silage was partially replaced with straw to increase the undigested neutral detergent fiber (uNDF) concentration on performance and carcass characteristics of finishing steers. Four hundred and fifty yearling commercial crossbred steers with an initial body weight (BW) of 432 ± 30.5 kg were allocated to 30 pens and fed diets containing 90% concentrate:10% forage for 123 d in a completely randomized block design with a 2 × 2 + 1 factorial arrangement. Treatments included 1) barley silage (BarS) with low peNDF (LpeNDF); 2) BarS with high peNDF (HpeNDF); 3) BarS with straw to yield a diet with LpeNDF + uNDF; 4) wheat silage (WhS) LpeNDF; and 5) WhS HpeNDF. There were no silage × peNDF interactions for dry matter intake (DMI), average daily gain (ADG), or gain to feed ratio (G:F), but cattle fed WhS LpeNDF had a lower (P &lt; 0.01) proportion of yield grade 3 and a greater proportion in yield grade 2 carcasses than cattle fed BarS LpeNDF or HpeNDF and WhS HpeNDF. Cattle fed WhS LpeNDF had greater (P = 0.02) incidence of severe liver abscesses when compared with cattle fed BarS LpeNDF or HpeNDF and WhS HpeNDF. Cattle fed BarS consumed less (P &lt; 0.01) uNDF as a percentage of BW, had increased (P = 0.02) ADG, heavier (P = 0.02) hot carcass weight, with greater (P = 0.01) back fat thickness, and (P &lt; 0.01) incidence of minor liver abscesses when compared with cattle fed WhS. Feeding HpeNDF did not affect DMI, ADG, or G:F, but increased (P = 0.02) marbling score and reduced (P &lt; 0.01) the proportion AA quality grade and increased (P &lt; 0.01) those classified as AAA when compared with cattle fed LpeNDF. Cattle fed low uNDF had lesser (P &lt; 0.01) uNDF intake as a percentage of BW, greater dressing percentage (P = 0.01), had a lower (P &lt; 0.01) proportion of carcasses in yield grade 2, and a greater (P &lt; 0.01) proportion of carcasses in yield grade 3 when compared with cattle fed high uNDF. Thus, silage source, peNDF, and uNDF content do not impact DMI or G:F when diets contain 10% forage, but BarS relative to WhS as well strategies increasing the peNDF concentration may increase ADG, HCW, back fat thickness, dressing percentage, marbling score, and carcasses classified as quality grade AAA. Future research is needed to evaluate the usefulness of peNDF and uNDF in rations for finishing cattle.
Intramedullary Antibiotic Depot Does Not Preclude Successful Intramedullary Lengthening or Compression
Authors: Rivera Jessica C. , McClure Philip K. , Fragomen Austin T. , Mehta Samir , Rozbruch S. Robert , Conway Janet D. 
Published: January 2021

Summary:
The challenging problem of long bone infection and limb length difference cannot be addressed using only an antibiotic-coated nonmagnetic static nail. The combined use of resorbable calcium sulfate and magnetic lengthening nails offers a possible solution to this dilemma, as well as for infected nonunions that require compression. We present a combined technique to treat or prevent infection using femoral or tibial intramedullary antibiotic delivery with an absorbable calcium sulfate depot and concomitant internal lengthening or compression using a nail. Adequate débridement is required in cases of established infection and is a prerequisite for this technique.
Antimicrobial Activity of Ceftazidime-Avibactam Against Contemporary Pathogens From Urinary Tract Infections and Intra-abdominal Infections Collected From US Children During the 2016–2019 INFORM Surveillance Program
Authors: Lin Lynn-Yao , Riccobene Todd , Debabov Dmitri 
Published: January 2021

Background:
Antibacterial activity of ceftazidime-avibactam (CAZ-AVI) was evaluated against bacterial isolates from children in the United States with a urinary tract infection (UTI) or intra-abdominal infection (IAI) during the 2016–2019 International Network for Optimal Resistance Monitoring program. Prevalence of isolates and susceptibility to CAZ-AVI in pediatric and adult patients were compared.

Methods:
Bacterial isolates were collected from children with a UTI or IAI at 70 US medical centers from 2016 to 2019. The antimicrobial activity of CAZ-AVI and comparator agents was tested by broth microdilution methods.

Results:
The most prevalent Enterobacterales pathogens in children with UTIs were Escherichia coli (62.5%), Klebsiella pneumoniae (12.1%) and Proteus mirabilis (6.2%). Minimum inhibitory concentration 90% values for CAZ-AVI against Enterobacterales (0.25 μg/mL) and Pseudomonas aeruginosa (4 μg/mL) were identical for children and adults. The most prevalent Enterobacterales pathogens in children with IAIs were E. coli (57.4%), K. pneumoniae (11.1%) and Enterobacter cloacae species complex (9.3%). All isolates of Enterobacterales from pediatric patients with UTI and IAI were susceptible to CAZ-AVI, including extended-spectrum β-lactamase phenotypes. Susceptibility of P. aeruginosa isolates to CAZ-AVI was 96.2% in children and 98.4% in adults with a UTI: for IAI it was 100% and 97.2%, respectively.

Conclusions:
Contemporary UTI and IAI pathogens collected from US children from 2016 to 2019 exhibited similar prevalence and susceptibilities as isolates collected from adult patients. CAZ-AVI exhibited potent activity against these pathogens.
Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers and the Risk of SARS-CoV-2 Infection or Hospitalization With COVID-19 Disease: A Systematic Review and Meta-Analysis
Authors: Tleyjeh Imad M. , Bin Abdulhak Aref A. , Tlayjeh Haytham , Al-Mallah Mouaz H. , Sohail M. Rizwan , Hassett Leslie C. , Siller-Matula Jolanta M. , Kashour Tarek 
Published: January 2021

Background:
SARS-CoV-2 infects its target cells via angiotensin converting enzyme 2 receptor, a membrane-bound protein found on the surface of many human cells. Treatment with angiotensin converting enzyme inhibitors (ACEI) or angiotensin receptors blockers (ARB) has been shown to increase angiotensin converting enzyme 2 expression by up to 5-fold.

Areas of uncertainty:
These findings coupled with observations of the high prevalence and mortality among SARS-CoV-2-infected patients with underlying cardiovascular disease have led to a speculation that ACEIs/ARBs may predispose to higher risk of being infected with SARS-CoV-2. Therefore, we systematically reviewed the literature and performed a meta-analysis of the association between prior use of ACEIs and ARBs and the risk of SARS-CoV-2 infection or hospitalization due to COVID-19 disease.

Data sources:
We searched Ovid MEDLINE(R) and Epub Ahead of Print, In-Process & Other Non-Indexed Citations and Daily, Ovid Embase, Ovid Cochrane Central Register of Controlled Trials, Ovid Cochrane Database of Systematic Reviews, Web of Science, Scopus, and Medrxiv.org preprint server until June 18, 2020.

Therapeutic advances:
Ten studies (6 cohorts and 4 case control) that enrolled a total of 23,892 patients and 853,369 controls were eligible for inclusion in our meta-analysis. One study was excluded from the analysis because of high risk of bias. Prior use of ACEIs was not associated with an increased risk of acquiring SARS-CoV-2 or hospitalization due to COVID-19 disease, odds ratio 0.98, 95% confidence interval (0.91–1.05), I2 = 15%. Similarly, prior use of ARBs was not associated with an increased risk of acquiring SARS-CoV-2, odds ratio 1.04, 95% confidence interval (0.98–1.10), I2 = 0%.

Conclusion:
Cumulative evidence suggests that prior use of ACEIs or ARBs is not associated with a higher risk of COVID-19 or hospitalization due to COVID-19 disease. Our results provide a reassurance to the public not to discontinue prescribed ACEIs/ARBs because of fear of COVID-19.
Global bifurcation at isolated singular points of the Hadamard derivative
Authors: Stuart C. A. 
Published: January 2021

Consider

F
∈
C
(

R

×
X
,
Y
)

such that
F
(
λ
, 0) = 0 for all

λ
∈

R

, where
X
and
Y
are Banach spaces. Bifurcation from the line

R

×
{
0
}

of trivial solutions is investigated in cases where
F
(
λ
, · ) need not be Fréchet differentiable at 0. The main results provide sufficient conditions for
μ
to be a bifurcation point and yield global information about the connected component of

{
(
λ
,
u
)
:
F
(
λ
,
u
)
=
0

and

u
≠
0
}
∪
{
(
μ
,
0
)
}

containing (
μ
, 0). Some necessary conditions for bifurcation are also formulated. The abstract results are used to treat several singular boundary value problems for which Fréchet differentiability is not available.

This article is part of the theme issue ‘Topological degree and fixed point theories in differential and difference equations’.
High levels of plasminogen activator inhibitor-1, tissue plasminogen activator and fibrinogen in patients with severe COVID-19
Authors: Cabrera-Garcia David , Miltiades Andrea , Parsons Samantha , Elisman Katerina , Mansouri Mohammad Taghi , Wagener Gebhard , Harrison Neil L. 
Published: January 2021

AbstractWe measured plasma levels of fibrinogen, plasminogen, tissue plasminogen activator (t-PA) and plasminogen activation inhibitor 1 (PAI-1) in blood from 37 patients with severe coronavirus disease-19 (COVID-19) and 23 controls. PAI-1, t-PA and fibrinogen levels were significantly higher in the COVID-19 group. Increased levels of PAI-1 likely result in lower plasmin activity and hence decreased fibrinolysis. These observations provide a partial explanation for the fibrin- mediated increase in blood viscosity and hypercoagulability that has previously been observed in COVID-19. Our data suggest that t-PA administration may be problematic, but that other interventions designed to enhance fibrinolysis might prove useful in the treatment of the coagulopathy that is often associated with severe COVID-19.