bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proposal to extend the PROMIS® item bank v2.0 ‘Ability to Participate in Social Roles and Activities’: item generation and content validity
Authors: van Leeuwen Lisette M. , Tamminga Sietske J. , Ravinskaya Margarita , de Wind Astrid , Hahn Elisabeth A. , Terwee Caroline B. , Beckerman Heleen , Boezeman Edwin J. , Hoving Jan L. , Huysmans Maaike A. , Nieuwenhuijsen Karen , de Boer Angela G. E. M. , van der Beek Allard J. 
Published: June 2020

AbstractPurposePrevious research indicated that the Patient-Reported Outcomes Measurement Information System (PROMIS®) item bank v2.0 ‘Ability to Participate in Social Roles and Activities’ may miss subdomains of social participation. The purpose of this study was to generate items for these missing subdomains and to evaluate their content validity.MethodsA three-step approach was followed: (1) Item generation for 16 International Classification of Functioning Disability and Health subdomains currently not covered by the item bank; (2) Evaluation of content validity of generated items through expert review (n = 20) and think-aloud interviews with a purposeful sample of people with and without (chronic) health conditions (n = 10), to assess item comprehensibility, relevance, and comprehensiveness; and 3) Item revision based on the results of step 2, in a consensus procedure.ResultsFirst, 48 items were generated. Second, overall, content experts indicated that the generated items were relevant. Furthermore, based on experts’ responses, items were simplified and ‘participation in social media’ was identified as an important additional subdomain of social participation. Additionally, ‘participating in various social roles simultaneously’ was identified as a missing item. Based on the responses of the interviewed adults items were simplified. Third, in total 17 items, covering 17 subdomains, were proposed to be added to the original item bank.DiscussionThe relevance, comprehensibility and comprehensiveness of the 17 proposed items were supported. Whether the proposed extension of the item bank leads to better psychometric properties of the item bank should be tested in a large-scale field study.
Can the provision of sexual healthcare for oncology patients be improved? A literature review of educational interventions for healthcare professionals
Authors: Albers L.F. , Palacios L.A. Grondhuis , Pelger R.C.M. , Elzevier H.W. 
Published: June 2020

Abstract
Purpose
Sexual health is an important quality-of-life concern for cancer patients and survivors, but a difficult discussion topic for patients and healthcare professionals. The most important barriers causing healthcare professionals to avoid the topic are lack of education and lack of knowledge. How effective education about sexual health is for oncology healthcare professionals is not clear. The aim of this review is to examine the effectiveness of interventions in improving the provision of sexual healthcare for cancer patients.

Methods
A systematic literature review was conducted according to PRISMA guidelines using the following data sources: PubMed, PsychInfo, Embase and Emcare. Quantitative research was included which contained pre-intervention and post-intervention outcomes. The assessment of the studies was conducted independently by two reviewers. A third reviewer was involved if there was no consensus.

Results
Seven studies were included. In total, 572 oncology healthcare professionals participated, including physicians, nurses and allied healthcare professionals. Interventions consisted of 6 face-to-face sessions and one online program. Primary objectives of the studies were the assessment of improvement in knowledge about sexual health, improvement of practice, frequency of discussing sexual health and comfort level and the decline of perceived barriers to discussing sexual health. Studies showed that interventions resulted in improved realization of the objectives.

Conclusions
Although improvement in the knowledge of healthcare professionals was achieved, it was not possible to give an overall recommendation for the development of interventions due to the limited number of studies and heterogeneity of the data.

Implications for Cancer Survivors
Sexual health is an important area of survivorship that is often neglected. Many oncology healthcare professionals lack training and knowledge to provide such care. More evidence-based practices are needed to improve sexual healthcare for cancer survivors.
Prognostic impact of Claudin 18.2 in gastric and esophageal adenocarcinomas
Authors: Arnold A. , Daum S. , von Winterfeld M. , Berg E. , Hummel M. , Rau B. , Stein U. , Treese C. 
Published: June 2020

Abstract
Introduction
The tight junction molecule Claudin 18.2 is selectively expressed in healthy and malignant gastric epithelial tissue and is a promising therapy target for high Claudin 18.2 expressing adenocarcinomas of the esophagogastric junction and stomach (AEG/S).

Methods
This study analyzed the prevalence, characteristics and prognostic impact of Claudin 18.2 expression in primary tumor, lymph node and distant metastasis in a large Caucasian AGE/S cohort with 414 patients.

Results
Claudin 18.2 was highly expressed in 17.1% of primary tumors, 26.7% of lymph node metastasis and 16.7% of distant metastasis. High Claudin 18.2 expression in lymph node metastasis and primary tumors correlated significantly (p < 0.001). High expression of Claudin 18.2 was neither associated with histomorphogical subtype, or tumor state, nor with overall survival.

Conclusion
In Caucasian AEG/S patients, 17.1% appeared to be eligible for an anti-Claudin 18.2 therapy. Claudin 18.2 expression itself has no impact on prognosis and is not related to any tumor subtype.
Energy Use Efficiency of Biogas Production Depended on Energy Crops, Nitrogen Fertilization Level, and Cutting System
Authors: Oleszek Marta , Matyka Mariusz 
Published: June 2020

AbstractThe paper evaluates the relation between energy input (Ei) and output (Eo) of biogas production from six energy crops: maize, sorghum, sunflower, triticale, reed canary grass (RCG), and Virginia mallow (VM), cultivated in three different nitrogen fertilization levels. Furthermore, in the case of RCG, the impact of cutting system was examined. The results showed that raised N fertilization dose (in the range of 40–120 kg ha−1and 80–160 kg ha−1, depending on the crops) increased biomass yield and methane productivity (MP) but simultaneously caused also the increase in Ei. Nonetheless, the application of higher N doses did not cause drastic decrease in energy use efficiency (EUE). The Eiwas significantly lower for perennials than for annual crops. For this reason, EUE for RCG harvested in two cuts (5.0–5.2 GJ GJ−1) was close to EUE for maize (5.7–6.8 GJ GJ−1), despite the much lower MP (2027–2903 m3 ha−1and 4409–5692 m3 ha−1, respectively) and Eo(73–105 GJ ha−1and 159–205 GJ ha−1, respectively). Furthermore, the collection of RCG in more than two cuts turned out to be unjustified, due to increase in Eiand, simultaneously, decrease in MP.
Breast-conserving surgery with intraoperative radiotherapy in recurrent breast cancer: the patient’s perspective
Authors: Elfgen Constanze , Güth U. , Gruber G. , Birrer S. , Bjelic-Radisic V. , Fleisch M. , Tausch C. J. 
Published: June 2020

Abstract
Purpose
When ipsilateral breast-tumor recurrence (IBTR) following breast-conserving surgery (BCS) occurs, the cure of a potentially life-threatening disease is the main goal. If, however, this is diagnosed early, prognosis is still good and patient-reported outcomes become more important. Despite the fact that many patients would prefer a further BCS, international breast cancer guidelines still recommend mastectomy, mainly because previous radiation implies limited options. Our comparative study evaluates the long-term quality-of-life and outcome in patients with IBTR who received BCS plus intraoperative radiotherapy (IORT) versus mastectomy.

Methods
Patients with IBTR were retrospectively divided into three groups according to the local treatment: group 1 (n = 26) was treated with BCS + IORT; group 2 (n = 35) received a standard mastectomy; group 3 (n = 52) had a mastectomy with subsequent reconstruction. Outcomes were analyzed after a mean follow-up of 5 years after IBTR. Quality-of-life was evaluated by the validated questionnaire BREAST-Q in 50 patients who fulfilled the inclusion criteria.

Results
Quality-of-life scores varied within the groups, ranging from 51.4 to 91.3 (out of 100 points). We observed satisfactory scores in all items, with no statistical difference within the groups. Disease-free survival of all groups did not statistically differ, and overall mortality was very low (0.9%). The postinterventional complication rate was lower after BCS (19.2% versus 34.3% after mastectomy and 30.8% after mastectomy with reconstruction).

Conclusion
For patients with previous surgery and radiation who demand a second BCS in the recurrent situation, this surgical technique can be offered in combination with IORT. Our long-term results imply oncological safety, lower complication rate, and good patient satisfaction.
Categorisation of building data in the digital documentation of heritage buildings
Authors: Khalil Ahmed , Stravoravdis Spyridon , Backes Dietmar 
Published: June 2020

AbstractThe documentation of heritage buildings is the preliminary action to deal with any problem related to the built heritage. The procedure of documentation requires a very diverse range of data (quantitative and qualitative) to be obtained and investigated in order to produce an accurate digital representation of the building. This type of work of data capture and interpretation is often conducted in isolation by different stakeholders and for a range of purposes, leading to a lack of communication between different data types, repeated effort and incomplete documentation. Heritage Building Information Modelling (H-BIM) is set to play a key role in the digital documentation of heritage buildings, as it can combine quantitative and qualitative data and facilitate the integration of different stakeholders and specialised data into the digital management of the different phases of dealing with heritage buildings. This paper aims to review the multitude of data types that could be included in the documentation and investigation process of the built heritage, in order to assess the breadth and depth by which heritage buildings can be documented. Four main categories that span the whole documentation data areas are being suggested which vary from outer geometry surveys, to subsurface materials and structural integrity investigations, to data concerning the building performance, as well as the historic records concerning the building’s morphology over time, which can help to create a more in-depth knowledge about the heritage building’s status and performance and can create a solid base for any required restoration and retrofitting processes (Khalil and Stravoravdis 2019a).
Sharks, rays and skates (Chondrichthyes, Elasmobranchii) from the Upper Marine Molasse (middle Burdigalian, early Miocene) of the Simssee area (Bavaria, Germany), with comments on palaeogeographic and ecological patterns
Authors: Villafaña Jaime A. , Marramà Giuseppe , Klug Stefanie , Pollerspöck Jürgen , Balsberger Markus , Rivadeneira Marcelo , Kriwet Jürgen 
Published: June 2020

AbstractElasmobranch remains are quite common in Miocene deposits and were the subject of numerous studies since the middle of the nineteenth century. Nevertheless, the taxonomic diversity of the Marine Molasse sharks, rays and skates is still largely unknown. Here, we describe 37 taxa from the lower Miocene of the Molasse Basin: 21 taxa could be identified at species level, whereas 15 taxa could only be assigned to genus and one taxon is left as order incertae sedis. The material was collected from deposits of the Auwiesholz Member of the Achen Formation (middle Burdigalian, middle Ottnangian age, ca. 17.8 Ma) exposed near Simssee, Upper Bavaria. This faunal assemblage is a mixture of shallow marine, near-coastal, pelagic and deep-water taxa. The fauna from Simssee displays different biogeographic dynamics at local and regional scales, possibly related to the intense climatic, oceanographic and tectonic events that occurred during the Eggenburgian–Ottnangian stages. The faunal relationships of the early Miocene chondrichthyan faunas from the Mediterranean Sea and Paratethys with others regions are established on the basis of qualitative (presence/absence) data. The beta diversity (Sørensen–Dice coefficient) of the Miocene Molasse elasmobranchs was used to characterize the taxonomic differentiation between localities and regions. According to our results, the fauna from Simssee shows close similarities with those from Switzerland, Austria, France and northern Germany. Faunal similarities and differences are mainly related to tectonic events and oceanographic variables (i.e. migration through seaway passages) or might represent collecting biases.
Modeling of the immune response in the pathogenesis of solid tumors and its prognostic significance
Authors: Zadka Łukasz , Grybowski Damian J. , Dzięgiel Piotr 
Published: June 2020

Abstract
Background
Tumor initiation and subsequent progression are usually long-term processes, spread over time and conditioned by diverse aspects. Many cancers develop on the basis of chronic inflammation; however, despite dozens of years of research, little is known about the factors triggering neoplastic transformation under these conditions. Molecular characterization of both pathogenetic states, i.e., similarities and differences between chronic inflammation and cancer, is also poorly defined. The secretory activity of tumor cells may change the immunophenotype of immune cells and modify the extracellular microenvironment, which allows the bypass of host defense mechanisms and seems to have diagnostic and prognostic value. The phenomenon of immunosuppression is also present during chronic inflammation, and the development of cancer, due to its duration, predisposes patients to the promotion of chronic inflammation. The aim of our work was to discuss the above issues based on the latest scientific insights. A theoretical mechanism of cancer immunosuppression is also proposed.

Conclusions
Development of solid tumors may occur both during acute and chronic phases of inflammation. Differences in the regulation of immune responses between precancerous states and the cancers resulting from them emphasize the importance of immunosuppressive factors in oncogenesis. Cancer cells may, through their secretory activity and extracellular transport mechanisms, enhance deterioration of the immune system which, in turn, may have prognostic implications.
Zielgerichtete Therapie beim metastasierten Mammakarzinom – welche molekularen Tests sind notwendig?
Authors: Schmidt Marcus 
Published: June 2020

ZusammenfassungIn den letzten Jahren ist die zielgerichtete Therapie beim Mammakarzinom immer mehr in den Fokus gerückt. Neben den Hormonrezeptoren und dem humanen epidermalen Wachstumsfaktor 2 (HER2) sind derzeit für die Festlegung einer gezielten Therapie vor allem der immunhistochemische Nachweis des „programmed cell death ligand 1“ (PD-L1) bei fortgeschrittenen triple-negativen Mammakarzinomen sowie der Nachweis von Mutationen im Breast-cancer-1(BRCA1)- oder BRCA2-Gen in der Keimbahn der Patientinnen und von Mutationen im Phosphatidylinositol-3-Kinase(PI3K)-Weg relevant.
Key factors determining biochar sorption capacity for metal contaminants: a literature synthesis
Authors: Thomas Evert , Borchard Nils , Sarmiento Christian , Atkinson Rachel , Ladd Brenton 
Published: June 2020

AbstractThe sorption capacity and affinity of biochar for metals are both important attributes that determine biochar’s suitability as a soil amendment for contaminant mitigation, yet few analyses have considered both characteristics simultaneously. We present a systematic review of literature published between 2010 and 2018 to test the hypothesis that sorption capacity and affinity are affected by biochar properties, attributes of the metal contaminant, and experimental conditions, in that order. We used random forest (RF) and multi-objective optimization to analyze data of 559 individual Langmuir adsorption isotherms extracted from 133 studies covering the sorption capacity (Cmax) and affinity (KL) of biochar for 17 different metals, elaborated from six different feedstock classes, three different types of feedstock pretreatment, and five types of post-pyrolysis treatment. Highest sorption values were obtained for Pb(II), Cr(IV), and Cd(II). The feedstock used was the key determinant influencing biochar’s capacity and affinity to sorb metal contaminants (first and fourth most important variable in RF models for Cmax and KL, respectively) with best results obtained for biochar elaborated from nutrient-dense feedstocks (animal biowaste, sludge, and manure). Biochars that had both high sorption capacity and affinity were the result of a longer duration of pyrolysis; they had lower C and higher N and O content, as well as lower C/N and higher O/C and H/C ratios, higher pore volumes and higher pH. Applying some form of pretreatment was better than none, whereas chemical modification was the best of the post-treatment methods analyzed. This review demonstrates clearly that multiple parameters during the preparation process influence the effectiveness of biochar to immobilize metal contaminants. Future research that focuses on mechanisms and the underlying factors for the correlations observed should allow the development of biochar formulations that are even more effective at immobilizing metal contaminants in soils and sediments.
No Way Back – Reflections on the Future of the African Photographic Archive
Authors: Schneider Jürg , Weinberg Paul 
Published: June 2020

Abstract:The article examines from a global perspective the phenomenon of digital photographic archiving and questions its impact on African archives both on the continent and outside it. The authors deal with the multi-layered consequences of information technologies for African photographic archives, asking to what degree they have connected Africa to the world. They consider too how much access they have given Africans to materials that were previously either unknown to them, or beyond their reach. Finally, the article explores how much opportunity digitization offers to agents of African photographic archives, empowered by technological developments.
“Curating Kisumu” and “Curating East Africa:” Academic Collaboration and Public Engagement in the Digital Age
Authors: Owino Meshack , Souther J. Mark 
Published: June 2020

AbstractThis essay examines the origin, permutations, potentials, challenges, and implications of two successive, collaborative public history research, teaching, and learning projects undertaken by the Department of History at Cleveland State University, Cleveland, Ohio, and the Department of History and Archeology at Maseno University, Kisumu, Kenya between 2014 and 2018. The two projects explored how opportunities created by the mobile revolution in Africa could be leveraged to generate new ways of acquiring historical information and knowledge between students and faculty in universities separated by enormous distances and by disparate social, economic, and political experiences. Specifically, the projects examined how the cellphone revolution could reshape the production and dissemination of knowledge about important sites, places, events, and people in modern Africa. The essay examines the conception and permutations of the two projects; identifies and explores their potentials and challenges; and proffers thoughts and suggestions that may guide similar future endeavors.
Prospective monitoring of carbapenem use and pseudomonal resistance across pediatric institutions
Authors: Miyairi Isao , Shoji Kensuke , Kinoshita Noriko , Saitoh Junpei , Sugahara Yoshie , Watanabe Yasushi , Komura Makoto , Kasai Masashi , Horikoshi Yuho , Shinjoh Masayoshi , Igarashi Takashi 
Published: June 2020

AbstractObjective:To determine whether carbapenem consumption andPseudomonas aeruginosaresistance rates can be used as benchmarks to compare and improve antimicrobial stewardship programs across multiple pediatric hospitals.Design:A prospective study.Setting and participants:Healthcare institutions in Japan with >100 pediatric beds.Methods:An annual survey of the total days of therapy (DOT) per 1,000 patient days for carbapenem antibiotics (meropenem, imipenem-cilastatin, panipenem-betamipron, doripenem) and susceptibility rates ofPseudomonas aeruginosato meropenem and imipenem-cilastatin from each institution was conducted over a 7-year period. Data were reported to the administration, as well as to the infection control team, of each institution annually.Results:Data were obtained from 32 facilities. The median total carbapenem DOT per 1,000 patient days was 16.6 and varied widely, with a range of 2.7 to 59.0. The median susceptibility to meropenem was 86.6%, ranging from 78.6% to 96.6%. We detected an inverse correlation between total carbapenem DOT versus susceptibility (r= – 0.36;P< .01). Over the 7-year period, the DOT per 1,000 patient days of carbapenem decreased by 27% from a median of 16.0 to 11.7 (P< .01). We also observed an improvement in susceptibility to meropenem from a median of 87% to 89.7% (P= .01) and to imipenem-cilastatin from 79% to 85% (P< .01). The decreases in the use of carbapenem were greater in institutions with antimicrobial stewardship programs led by pediatric infectious disease specialists.Conclusions:Antimicrobial use and resistance, targeting carbapenems andP. aeruginosa, respectively, can serve as benchmarks that can be utilized to promote antimicrobial stewardship across pediatric healthcare institutions.
DATING ADOPTION AND INTENSIFICATION OF FOOD-CROPS: INSIGHTS FROM 4MSR (BINJOR), AN INDUS (HARAPPAN) SITE IN NORTHWESTERN INDIA
Authors: Sharma Shalini , Manjul Sanjay Kumar , Manjul Arvin , Pande Puran Chand , Pokharia Anil K 
Published: June 2020

ABSTRACTHere we present direct dates of food grains and insights into agricultural strategies adopted by Harappans from a newly excavated Indus site 4MSR (Binjor) in northwestern India. The site revealed Early and Mature Harappan phases delimited by a Transitional phase based on ceramics and archaeological artifacts. The macro-botanical remains revealed that the site was occupied by an agricultural society during the Early phase (~2900−2600 BCE), whereas diversification of the economy including more craft specialization, along with an agricultural advancement was witnessed during the Mature phase (~2500−1800 BCE). The advent of summer crops during the Transitional phase (~2600−2500 BCE) indicates climate amelioration attributed to inception of strong Indian Summer Monsoon (ISM). By the end of Mature phase, millet was recorded due to a change in climatic (relatively lower moisture) conditions or drying of the river channel, which forced the settlers to shift the cropping (agricultural) strategy in the region. Plausibly, this unavailability of water during the end of Mature phase led the settlers to abandon the site in order to migrate somewhere else. The subsistence pattern indicates continuity and change in temporal domain likely owing to changing climatic/environmental conditions, resources and knowledge gained by exchange/trade of cultures over a time period between ~2900 BCE to 1800 BCE.