bluuebunny/crossref_metadata_2025_split huggingface dataset:
BRD4 Levels Determine the Response of Human Lung Cancer Cells to BET Degraders That Potently Induce Apoptosis through Suppression of Mcl-1
Authors: Zong Dan , Gu Jiajia , Cavalcante Giovanna C. , Yao Weilong , Zhang Guojing , Wang Shaomeng , Owonikoko Taofeek K. , He Xia , Sun Shi-Yong 
Published: March 2020

Abstract

Lung cancer consists of approximately 80% non–small cell lung cancer (NSCLC) and 20% small cell lung cancer (SCLC) and remains the leading cause of cancer-related deaths worldwide despite advances in early diagnosis, targeted therapy, and immunotherapy. Thus, novel therapies are still urgently needed. Bromodomain and extraterminal (BET) proteins, primarily comprised of BRD2, BRD3, and BRD4 proteins, function as epigenetic readers and master transcription coactivators and are now recognized cancer therapeutic targets. BET degraders such as ZBC260 and dBET represent a novel class of BET inhibitors that act by inducing BET degradation. The current study demonstrates the therapeutic efficacies of BET degraders, particularly ZBC260, against lung cancer, as well as understanding the underlying mechanisms and identifying molecular markers that determine cell sensitivity to BET degraders. A panel of NSCLC cell lines possessed similar response patterns to ZBC260 and dBET but different responses to BET inhibitor JQ-1. BRD levels, particularly BRD4, correlated positively with high sensitivity to BET degraders but not to JQ-1. BET degraders potently induced apoptosis in sensitive NSCLC cells and were accompanied by reduction of Mcl-1 and c-FLIP levels, which are critical for mediating induction of apoptosis and enhancement of TRAIL-induced apoptosis. Accordingly, ZBC260 exerted more potent activity than JQ-1 in vivo against the growth of NSCLC xenografts and patient-derived xenografts. These findings warrant future clinical validation of the efficacy of BET degraders in NSCLC, particularly those with high levels of BRD proteins, especially BRD4.

Significance:
The current study demonstrates the potential of novel BET degraders in the treatment of lung cancer and warrants clinical validation of BET degraders in lung cancer with high levels of BRD4.
Contributors to the Growth of Same Day Discharge After Elective Percutaneous Coronary Intervention
Authors: Taxiarchi Paraskevi , Martin Glen P. , Kinnaird Tim , Curzen Nick , Ahmed Javed , Ludman Peter , De Belder Mark , Shoaib Ahmad , Rashid Muhammad , Kontopantelis Evangelos , Mamas Mamas A. 
Published: March 2020

Background:
Financial pressures for reducing hospitalization costs have driven to a move toward same day discharge (SDD) following uncomplicated percutaneous coronary intervention. The UK healthcare system has transitioned to predominantly SDD for elective percutaneous coronary intervention. This study aimed to examine patient’s clinical, procedural, and institutional characteristics that are associated with the increased adoption of SDD adoption over time in the United Kingdom and determine whether these vary by region.

Methods:

The data were derived from the British Cardiovascular Intervention Society including all the elective percutaneous coronary intervention from 2007 to 2014 in the United Kingdom. We structured 8 meaningful groups of variables, and their relative importance was obtained by decomposing the R
2
in each study year.

Results:
The relative importance of Strategic Health Authorities was substantially higher than all other factors every year, with some reduction over time, from 49.2% (95% CI, 45.4%–52.4%) in 2007 to 43.4% (95% CI, 39.9%–46.6%) in 2014. Center volume followed with 8.95% (95% CI, 7.0%–10.9%) to 19.8% (95% CI, 16.7%–22.4%). Between patients’ clinical and procedural characteristics, pharmacology and access site had the highest relative importance values, from 14.3% (95% CI, 12.1%–16.4%) to 7.1% (95% CI, 5.5%–8.8%) and from 3.6% (95% CI, 2.3%–5.1%) to 11.8% (95% CI, 9.4%–14.3%), respectively. Relative importance of different groups varied differently across Strategic Health Authorities.

Conclusions:
Growth of SDD was mainly associated with regional characteristics, while subcontributors varied substantially between different regions. Standardized guidelines would provide more homogenous adoption of SDD nationally. This analysis might be of wider interest in healthcare systems slower in SDD adoption.
Checklist, Bibliography and Quantitative Data of the Arthropods of Hispaniola
Authors: PEREZ-GELABERT DANIEL E. 
Published: March 2020

An updated and extensively revised checklist of the arthropods of Hispaniola (Dominican Republic and Haiti) is presented 11 years after the publication of the original in 2008. It integrates and quantifies all the terrestrial and surrounding marine arthropod species (plus those of Tardigrada and Onychophora), reported in the zoological literature for Hispaniola through the middle of 2019. A total of 9,920 valid species (8,202 extant and 1,718 fossil) are listed, which represents an increase of 1,683 species (1,369 extant and 314 fossil) from the original list. The largest component is Insecta (6,784 extant and 1,136 fossil), including 2,206 extant species of Coleoptera, 1,042 species of Hemiptera, 929 species of Diptera, 913 species of Lepidoptera and 774 species of Hymenoptera. Emphasis is on reviewing and updating the original list, including all newly recorded taxa and all pertinent taxonomic changes proposed since then. Important corrections have been made, and explanatory notes have been added. For example, multiple authors have confused the Lesser Antillean island of Dominica with the Dominican Republic. This error is much more common in the literature than was initially recognized. Erroneous records attributing species from one island to the other have been identified and corrected. The original spelling of the cricket species Scapsipedus bastardoi Otte & Perez-Gelabert, 2009, dedicated to Dominican biologist Ruth H. Bastardo, is corrected to Scapsipedus bastardoae nom. emend. High species endemism is typical of the biota of Caribbean islands. In this checklist, a total of 3,161 arthropod species (38.6%) are considered endemic or unique to Hispaniola. Among the speciose groups with higher levels of endemism are the Diplopoda (91.6%), Orthoptera (90.1%), Trichoptera (82.6%), Coleoptera (49.3%) and Araneae (47.5%). Also, a total of 201 arthropod species (174 insects + 27 non-insects) are identified as introduced to the island. The accompanying bibliography complements the taxonomic information and includes over 5,000 titles.
New species of Silhouettea (Teleostei: Gobiidae) from Qeshm Island, Iran and the DNA barcoding of the Persian Gulf and Oman Sea gobies
Authors: KOVAČIĆ MARCELO , SADEGHI REZA , ESMAEILI HAMID REZA 
Published: March 2020

Silhouettea ghazalae sp. nov. is described from Qeshm Island, Persian Gulf. Silhouettea ghazalae sp. nov. is distinguished from congeners by having: small mental fold present on chin, head length 31.4–32.4% of standard length, head width 24.5% of standard length, second dorsal fin I/11, anal fin I/13, breast with large cycloid scales, predorsal area naked, suborbital row b anteriorly beginning below anterior edge of pupil, posteriorly ending below pore β, suborbital row c anteriorly extending more than row b and posteriorly extending less than row b, suborbital row cp oblique with four papillae, body with four ill-defined midlateral blotches and the fifth a triangular mark on the caudal fin base, no clearly defined pale saddles on back, and the first dorsal fin pigmented with dots and with dark blotch present anteriorly. A key to Silhouettea species is provided. A dataset including novel and publicly available mtDNA COI sequences of 12 species from the Persian Gulf and Oman Sea gobies belonging to eight genera have been assembled in order to provide a reference dataset for DNA barcoding studies. The new species is further characterised by a minimum K2P distance of 21% to its closest relatives in our dataset, Cabillus tongarevae in the mtDNA COI barcode region.
Stroke in systemic lupus erythematosus: epidemiology, mechanism, and long-term outcome
Authors: Guraieb-Chahín P , Cantú-Brito C , Soto-Mota A , Guerrero-Torres L , Flores-Silva F , Chiquete E , Fragoso-Loyo H , González-Duarte A , Valdés-Ferrer SI 
Published: March 2020

Objective To determine stroke prevalence, mechanisms, and long-term outcome in a cohort of Hispanic patients with systemic lupus erythematosus (SLE). Methods We analyzed demographical data, the timing between SLE diagnosis and stroke onset, stroke type, recurrence, and outcomes from an institutional database of 4451 patients with SLE followed from 1993 to 2018. Results We observed 139 strokes (3.1%), for an incidence rate of 1.25 per 1000 person-years: 81 (58.3%) acute ischemic stroke (AIS), 19 (13.7%) subarachnoid hemorrhage (SAH), 17 (12.2%) cerebral venous thrombosis, 13 (9.4%) intracerebral hemorrhage (ICH), and 9 (6.5%) transient ischemic attack. Median time from SLE diagnosis to acute stroke was 60 months (interquartile range 12–132 months). AIS had a bimodal presentation with 26% occurring within the first year and 30% >10 years after SLE diagnosis. In contrast, 75% of ICH cases occurred >3 years (and 34% >10 years) after SLE diagnosis. The most important cause of AIS was secondary antiphospholipid syndrome (48%). Hypertension was associated with 69% of ICH cases, while aneurysmal rupture was observed in 78% of SAH cases. Excellent recovery at hospital discharge was observed in 65%. Stroke recurrence was observed in 7%. The long-term all-cause fatality rate was 8%. Conclusions The prevalence of stroke in this cohort was 3.1%. Ischemic strokes had a bimodal presentation, occurring either early after SLE diagnosis or after a several-year delay. Half of the hemorrhagic strokes occurred >10 years after the diagnosis of SLE. Clinical outcome was usually good with a relatively low recurrence rate.
Exploring the Relationships Among Middle School Students’ Peer Interactions, Task Efficiency, and Learning Engagement in Game-Based Learning
Authors: Moon Jewoong , Ke Fengfeng 
Published: March 2020

Background. Middle school students’ math anxiety and low engagement have been major issues in math education. In order to reduce their anxiety and support their math learning, game-based learning (GBL) has been implemented. GBL research has underscored the role of social dynamics to facilitate a qualitative understanding of students’ knowledge. Whereas students’ peer interactions have been deemed a social dynamic, the relationships among peer interaction, task efficiency, and learning engagement were not well understood in previous empirical studies. Method. This mixed-method research implemented E-Rebuild, which is a 3D architecture game designed to promote students’ math problem-solving skills. We collected a total of 102 50-minutes gameplay sessions performed by 32 middle school students. Using video-captured and screen-recorded gameplaying sessions, we implemented behavior observations to measure students’ peer interaction efficiency, task efficiency, and learning engagement. We used association analyses, sequential analysis, and thematic analysis to explain how peer interaction promoted students’ task efficiency and learning engagement. Results. Students’ peer interactions were negatively related to task efficiency and learning engagement. There were also different gameplay patterns by students’ learning/task-relevant peer-interaction efficiency (PIE) level. Students in the low PIE group tended to progress through game tasks more efficiently than those in the high PIE group. The results of qualitative thematic analysis suggested that the students in the low PIE group showed more reflections on game-based mathematical problem solving, whereas those with high PIE experienced distractions during gameplay. Discussion. This study confirmed that students’ peer interactions without purposeful and knowledge-constructive collaborations led to their low task efficiency, as well as low learning engagement. The study finding shows further design implications: (1) providing in-game prompts to stimulate students’ math-related discussions and (2) developing collaboration contexts that legitimize students’ interpersonal knowledge exchanges with peers.
Towards more credible shams for physical interventions: A Delphi survey
Authors: Braithwaite Felicity A , Walters Julie L , Moseley G Lorimer , Williams Marie T , McEvoy Maureen P 
Published: March 2020

Background/Aims: In clinical trials of physical interventions, participant blinding is often poorly addressed and therapist blinding routinely omitted. This situation presents a substantial barrier to moving the field forward. Improving the success of blinding will be a vital step towards determining the true mechanisms of physical interventions. We used a Delphi approach to identify important elements of shams for physical interventions to maximise the likelihood of participant and therapist blinding in clinical trials. Methods: Two expert groups were recruited: (1) experts in research methodology and (2) experts in deceptive and/or hypnotic techniques including magic. Magicians were included because they were considered a potentially rich source of innovation for developing credible shams due to their unique skills in altering perceptions and beliefs. Three rounds of survey were conducted, commencing with an open-ended question. Responses were converted to single ‘items’, which participants rated in the following two rounds using a 9-point Likert scale, categorised as ‘Not important’ (0–3), ‘Depends’ (4–6) and ‘Essential’ (7–9). Consensus was pre-defined as ≥80% agreement within a 3-point category. Results: Thirty-eight experts agreed to participate (research methodology: n = 22; deceptive and/or hypnotic techniques: n = 16), and 30 experts responded to at least one round (research methodology: n = 19; deceptive and/or hypnotic techniques: n = 11). Of 79 items, five reached consensus in the ‘Essential’ category in both groups, which related to beliefs of participants ( n = 3 items), interactions with researchers ( n = 1 item) and standardisation of clinical assessments ( n = 1 item). Thirteen additional items reached consensus in the ‘Essential’ category in one group. Experts in research methodology had one additional item reach consensus, related to authentic delivery of study information. The remaining 12 additional items that reached consensus in the deceptive and/or hypnotic techniques group related mainly to therapist attitude and behaviour and the clinical interaction. Conclusion: Experts agreed that, for shams to be believable, consideration of cognitive influences is essential. Contrary to the focus of previous shams for physical interventions, replicating the tactile sensation of the active treatment was not considered an essential part of sham development. Therefore, when designing sham-controlled clinical trials, researchers should carefully consider the cognitive credibility of the entire intervention experience, and not just the indistinguishability of the sham intervention itself. The findings provide new guidance to researchers on important contributors to blinding in physical intervention trials.
Analysis of Sinus Balloon Catheter Dilation Providers Based on Medicare Provider Utilization and Payment Data
Authors: Munteanu Teona , Ference Elisabeth H. , Danielian Arman , Talati Vidit M. , Kern Robert C. , Eloy Jean Anderson , Smith Stephanie Shintani 
Published: March 2020

Background The use of balloon catheter dilation (BCD) to treat chronic rhinosinusitis has increased dramatically since its conception, necessitating further characterization of BCD providers and trends in its usage. Medicare data on BCD providers have made it possible to study recent demographic patterns. There has also been an increase in mid-level providers’ scope of otolaryngologic practice that is not well defined. Objective To better understand BCD adoption by studying volume of BCD procedures as well as training, geography, and practice socioeconomic characteristics of BCD providers for Medicare beneficiaries. Methods We reviewed Medicare Provider Utilization and Payment Data Public Use Files for 2014 and 2015 for providers with claims for BCD of the sinuses. We extracted provider zip code, state, gender, and number of services per BCD code. We obtained median household income by zip code and geographic region based on US Census Bureau data. Providers were classified using an Internet search to determine practice setting and type of specialty training/certification. Results In 2014 and 2015, 428 providers performed 42 494 BCDs billed to Medicare beneficiaries. Among BCD providers, 5.1% were female, 98.1% had Doctor of Medicine/Doctor of Osteopathic Medicine credentials, and 1.9% had nurse practitioner/physician assistant credentials. Over the 2-year period, the median number of BCDs was 63 for physicians and 37 for mid-level providers. Fellowship-trained rhinologists performed a median of 38 BCDs over 2 years. The most common subspecialty certification/training was in facial plastics and reconstructive surgery. The majority of providers (63.8%) performed 1 to 99 BCDs over the 2 years. In the South, there were 21.9 BCD procedures performed per 100 000 people compared to 7.3 in the Northeast, 9.3 in the Midwest, and 8.5 in the West. Conclusion There is a large range in total BCD procedures performed by individual providers, and this varies by certain provider characteristics. Mid-level providers have emerged as a significant population performing BCD.
Young GI Societies in Europe: 2019 update
Authors: Heinrich Henriette , Rodríguez‐Lago Iago , Nakov Radislav , Skuja Vita , Acedo Pilar , Nitsche Ulrich , Mikolasevic Ivana , van Herwaarden Yasmijn , Kocollari Adea , Harutyunyan Kristine , Dolak Werner , Loly Jean‐Philippe , Defeu Wiliam Soub , Sleeckx Sofie , Van Hootegem Anneleen , Nakov Radislav , Bokun Tomislav , Kral Jan , Burisch Johan , Eek Aileen , Liukkonen Ville , Hedjoudje Abdellah , Beyer Georg , Voulgaris Theodoros , Farkas Klaudia , O'Reilly Susanne , Ianiro Gianluca , Manfredi Guido , Skuja Vita , Sjomina Olga , Kupcinskas Juozas , Khannoussi Wafaa , Nikolovska Anche Volkanovska , Breder Sigurd , Molnes Sveinung , Salaga Maciej , Ferreira Rosa , Ilie Madalina , Lalosevic Milica Stojkovic , Ďuriček, Martin , Tepes Katja , Murcia Óscar , Moris María , Stenfors Iréne , Schreiner Philipp , van Herwaarden Yasmijn , Wielenga Mattheus , Altan Ege , Nikiforova Yana , Widlak Monika ,   Friends of the UEG Young Talent Group
Published: March 2020

BackgroundOne of the aims of the Young Talent Group (YTG) is to make United European Gastroenterology (UEG) more attractive to young fellows interested in gastroenterology (GI), and to actively involve them in UEG activities and the activities of their respective national societies. In 2017, we conducted a survey among the Friends of the UEG YTG with the aim of identifying the state of organization and needs of Young GI Sections (YGISs) throughout Europe, highlighting areas for further development and improvement.AimsThe aim of the current web‐based survey was to assess the progress of YGISs over 1 year, and persisting hurdles in forming and running a YGIS.ResultsOverall, 38 of 42 Friends answered the survey (91%). The number of YGISs has increased significantly from 12 in 2017 to 25 in 2019. Young gastroenterologists remained supported, but not influenced, by national societies. Results of the survey suggest that a lack of dedicated and motivated fellows has replaced a lack of funding as the most prevalent hurdle in forming these types of sections.ConclusionOur survey shows that the development of YGISs has improved markedly within the last 2 years. However, several limitations, like underrepresentation in subcommittees of national societies, remain and need to be addressed in order to involve young gastroenterologists in their respective national societies and within UEG, to pave the way for future research, education and excellent quality of care, and reduce health inequalities across Europe.
Predictive value of admission D-dimer for contrast-induced acute kidney injury and poor outcomes after primary percutaneous coronary intervention
Authors: Lin Kai-Yang , Chen Han-Chuan , Jiang Hui , Wang Sun-Ying , Chen Hong-Mei , Wu Zhi-Yong , Jiang Feng , Guo Yan-Song , Zhu Peng-Li 
Published: March 2020

Abstract
Background
DD was found to be associated with acute myocardial infarction (AMI) and renal insufficiency. However, it is uncertain whether DD is an independent risk factor of CI-AKI in patients undergoing pPCI.

Methods
We prospectively enrolled 550 consecutive patients with STEMI undergoing pPCI between January 2012 and December 2016. The predictive value of admission DD for CI-AKI was assessed by receiver operating characteristic (ROC) and multivariable logistic regression analysis. CI-AKI was defined as an absolute serum creatinine increase ≥0.3 mg/dl or a relative increase in serum creatinine ≥50% within 48 h of contrast medium exposure.

Results
Overall, the incidence of CI-AKI was 13.1%. The ROC analysis showed that the cutoff point of DD was 0.69 μg/ml for predicting CI-AKI with a sensitivity of 77.8% and a specificity of 57.3%. The predictive value of DD was similar to the Mehran score for CI-AKI (AUCDD = 0.729 vs AUCMehran = 0.722; p = 0.8298). Multivariate logistic regression analysis indicated that DD > 0.69 μg/ml was an independent predictor of CI-AKI (odds ratio [OR] = 3.37,95% CI:1.80–6.33, p < 0.0001). Furthermore, DD > 0.69 μg/ml was associated with an increased risk of long-term mortality during a mean follow-up period of 16 months (hazard ratio = 3.41, 95%CI:1.4–8.03, p = 0.005).

Conclusion
Admission DD > 0.69 μg/ml was a significant and independent predictor of CI-AKI and long-term mortality in patients undergoing pPCI.