bluuebunny/crossref_metadata_2025_split huggingface dataset:
Professional roles of general practitioners, community pharmacists and specialist providers in collaborative drug deprescribing - a qualitative study
Authors: Gerlach Navina , Michiels-Corsten Matthias , Donner-Banzhoff Norbert , Viniol Annika , Schleef Tanja , Junius-Walker Ulrike , Krause Olaf 
Published: April 2020

Abstract
Background: Collaborative care approaches between general practitioners (GPs) and pharmacists have received international recognition for medication optimisation and deprescribing efforts. Although even specialist providers have been shown to influence deprescribing, their profession so far remains omitted from collaborative care approaches for medication optimisation. Similarly, while explorative studies on role perception and collaboration between GPs and pharmacists grow, interaction with specialists for medication optimisation is neglected. Our qualitative study therefore aims to explore GPs`, community pharmacists` and specialist providers` role perceptions of deprescribing, and to identify interpersonal as well as structural factors that may influence collaborative medication optimisation approaches. Method: Seven focus-group discussions with GPs, community pharmacists and community specialists were conducted in Hesse and Lower Saxony, Germany. The topic guide focused on views and experiences with deprescribing with special attention to inter-professional cooperation. We used conventional content analysis following an inductive-deductive approach. Results: Our exploration of role perceptions revealed factors influencing deprescribing collaboration on both interpersonal and structural levels. On interpersonal level, conflicting role positions exposed in clashes of perceived authority, while conflicting role functions were indicated by disagreement on responsibility for deprescribing tasks between stakeholder groups, and resulted in underutilisation of services. Lacking communication was reported as a general barrier to cooperation. On a structural level, missing transparency on medication information across providers and deficient reimbursement for medication optimisation activities emerged as most pronounced obstacles for successful collaborative deprescribing. Also, unclear definition of task division between professional groups provoked difficulties. Conclusion: Revealing relevant stakeholders` role perceptions on their responsibilities and delimitations for joint deprescribing is a prerequisite for collaborative care approaches. Our study revealed several preconditions for joint deprescribing action that emerge from the German setting, but may as well inform other health-systems. As such, necessary medication transparency may be enabled by sector-wide electronic health records. For clarification of role definitions, joint training sessions across stakeholder groups may strengthen future cooperation. Finally, even redefining professional roles should be considered to strengthen GPs` regulatory functions and promote a continuity of care.
The BEACON Study: Protocol for a cohort study as part of an evaluation of the effectiveness of smartphone-assisted problem-solving therapy in men who present with intentional self-harm to Emergency Departments in Ontario
Authors: Hatcher Simon , Heisel Marnin , Ayonrinde Oyedeji , Campbell Julie Kathleen , Colman Ian , Corsi Daniel J. , Edgar Nicole E. , Gillett Lindsay , Kennedy Sidney H. , Hunt Sophia Lakatoo , Links Paul , MacLean Sarah , Mehta Viraj , Mushquash Christopher , Raimundo Alicia , Rizvi Sakina J. , Saskin Refik , Schaffer Ayal , Sidahmed Alaaddin , Sinyor Mark , Soares Claudio , Testa Valerie , Thavorn Kednapa , Thiruganasambandamoorthy Venkatesh 
Published: April 2020

Abstract
Background: Patients who present to Emergency Departments (ED) after intentional self-harm are at an increased risk of dying by suicide. This applies particularly to men, who represent nearly two-thirds of those who die by suicide in Ontario. One way of potentially addressing this gap is to offer a course of blended problem-solving therapy (PST), comprised of a brief course of evidence-based psychotherapy for individuals at-risk for suicide, facilitated by the use of a patient-facing smartphone application and a clinician-facing “dashboard”. This approach has the potential to combine the benefits of face to face therapy and technology to create a novel intervention.Methods: This is a cohort study, nested within a larger pragmatic multicentre pre- and post-design cluster randomized trial (cRCT). Suicidal ideas assessed by the Beck Scale for Suicide Ideation (BSS) is the primary outcome variable. Secondary outcome measures include: depression (PHQ-9); anxiety (GAD-7); PTSD (PC-PTSD); health-related quality of life (EQ-5D-5L); meaning in life (EMIL); perceived social supports (MSPSS); alcohol use (AUDIT); drug use (DAST-10); problem-solving skills (SPSI-R:S); self-reported health care costs; and, health service use measured using Ontario administrative health data. A process evaluation will also be conducted following study completion.Discussion: The cohort study will test whether better adherence to the intervention results in better outcomes. The value of the cohort study design is that we can examine in more detail certain sub-groups or other variables that are not available in the larger cluster randomised trial. This trial will aim to improve standards by informing best practice in management of men who self-harm and present to hospitals in Ontario. Trial registration: ClinicalTrials.gov: NCT03473535, Registered on March 22, 2018, https://clinicaltrials.gov/ct2/show/NCT03473535
Treatment Patterns and Clinical Outcomes in Patients with Metastatic Breast Cancer Treated with Palbociclib-Based Therapies: Real-World Data in the Han Population
Authors: Mo Hongnan , Ma Fei , Li Qing , Zhang Pin , Yuan Peng , Wang Jiayu , Luo Yang , Cai Ruigang , Li Qiao , Xu Binghe 
Published: April 2020

Abstract
Background: Palbociclib combined with endocrine therapy has become the standard treatment for estrogen receptor-positive (ER+) metastatic breast cancer. However, little is known about the effectiveness of diverse palbociclib-based regimens other than letrozole and fulvestrant in the real-world clinical setting. This study aimed to reveal the treatment patterns and clinical outcomes in Han patients in routine clinical practice. Methods: The clinical data of patients with ER+ metastatic breast cancer treated with palbociclib were collected from the China National Cancer Center database. The efficacy profile of palbociclib in this Han population was evaluated, especially in patients younger than 40 years, in those with bone-only metastasis, for various regimen combinations, and as subsequent systemic therapy. Propensity score matching was employed to match patients with or without previous everolimus treatment. Results: A total of 186 patients from 89 cities in 18 provinces in China were enrolled. Patients older than 40 years (P=0.189), those with metastasis other than bone metastasis (P=0.023), and those who received palbociclib as first-line treatment (P<0.001) had prolonged progression-free survival (PFS) compared with other patients. Median PFS was similar among different palbociclib-combined groups (P=0.566): 10.0 months (95% confidence interval [CI] 3.8–16.1) in the exemestane plus palbociclib group, 9.7 months (95% CI 6.3–13.1) in the letrozole plus palbociclib group, 7.8 months (95% CI 5.5–10.2) in the fulvestrant plus palbociclib group, 7.2 months (95% CI 3.2–11.3) in the toremifene plus palbociclib group, and 6.1 months (95% CI 1.2–11.0) in the anastrozole plus palbociclib group. Patients pretreated with everolimus had significantly worse PFS (3.4 months, 95% CI 0.7–6.1) than those in the everolimus-naïve group (8.8 months, 95% CI 6.6–11.0, P=0.001) in the whole population. After propensity score matching, patients pretreated with everolimus had inferior PFS (4.4 months, 95% CI 0.5–8.2) compared with everolimus-naïve patients (6.1 months, 95% CI 4.7–7.5, P=0.439). Conclusions: Various palbociclib-based regimens have promising efficacy in real-world settings, even in patients with bone-only metastasis. Palbociclib resistance is more common in patients younger than 40 years, in those pretreated with everolimus, and in the settings of subsequent treatment compared with first-line treatment.
Microencapsulation of cellular aggregate composed of differentiated insulin and glucagon-producing cells from human mesenchymal stem cells derived from adipose tissue.
Authors: Jara Claudia , Oyarzun-Ampuero Felipe , Carrión Flavio , González-Echeverría Esteban , Cappelli Claudio , Caviedes Pablo 
Published: April 2020

Abstract
Background. In type I diabetes mellitus (T1DM) pancreatic β cells are destroyed. Treatment entails exogenous insulin administration and strict diet control, yet optimal glycemic control is hardly attainable. Islet transplant could be an alternative in patients with poor glycemic control, but inefficient islet purification and autoimmune response of patients still a challenge. Methods Human adipose-derived mesenchymal stem cells (hASC) obtained from lipoaspirated fat tissue from human donors were differentiated in vitro to insulin (Ins) and glucagon (Gcg) producing cells (IPC and GPC respectively). Then, we cocultured IPC and GPC cells in low adhesion conditions to form cellular aggregates, which were encapsulated in a sodium alginate polymer. Expression of pancreatic lineage markers and secretion of insulin or glucagon in vitro were analyzed. Results We demonstrated that multipotent hASC efficiently differentiate to IPC and GPC, which also express pancreatic markers, including insulin or glucagon hormones. In turn, we calculated the Feret diameter of cellular aggregates, finding mean diameters ~80 µm at 72h of incubation. IPC/GPC aggregates were then microencapsulated in sodium-alginate polymer microgels, which were found to be more stable in Ba 2+ stabilized microgels, with average diameters ~300 µm. Interestingly, Ba 2+ -microencapsulated aggregates respond to high external glucose with insulin secretion. Conclusions The IPC/GPC differentiation process from hASC followed by generate cellular aggregates in vitro, that once microencapsulated could represent a possible treatment to T1DM.
Insulin U-500, the Practical Solution for the treatment of Patients with High Insulin Requirements
Authors: Mikhail Nasser 
Published: April 2020

Background:
Human regular insulin 500 (U-500) is 5 five times more concentrated than the
traditional regular human insulin (U-100). Thus, every 1 ml of U-500 contains 500 units of insulin as
opposed to 100 units/ml with most types of insulin.

Methods:
Review of all the relevant clinical studies related to insulin U-500 until February 12, 2020.

Results:
Insulin U-500 is indicated in patients with type 2 diabetes who require more than 200 units of
insulin per day. Insulin U-500 has both prandial and basal actions, and can be injected as monotherapy
in a convenient twice-daily regimen. Available data suggest that insulin U-500 is effective, associated
with better compliance, and decreased injection pain compared with non-concentrated insulins. Its main
limitations are hypoglycemia and weight gain, and the possibility of dosing errors.

Conclusions:
Overall, insulin U-500 is an effective and safe treatment for patients with type 2 diabetes
and insulin resistance. Randomized trials are needed to compare the long-term efficacy and safety of insulin
U-500 with other forms of insulin regimens.
CONTROL OF MHD MICROPOLAR FLUID FLOW
Authors: Kocić Miloš , Stamenković Živojin , Petrović Jelena , Nikodijević Milica 
Published: April 2020

In this paper, the steady flow and heat transfer of an incompressible electrically conducting micropolar fluid through a parallel plate channel is investigated. The upper and lower plate have been kept at the two constant different temperatures and the plates are electrically insulated. The applied magnetic field is perpendicular to the flow, while the Reynolds number is significantly lower than one i.e. the considered problem is in induction-less approximation. The general equations that describe the discussed problem under the adopted assumptions are reduced to ordinary differential equations and closed-form solutions are obtained. The influences of each of the governing parameters on velocity, heat transfer on the plates (Nusselt number), flow rate and skin friction are discussed with the aid of graphs.
Administración de la gestión humana
Authors: Peña Torres Parcival , Vargas Ramírez Adrián David , Rodríguez Ortiz Julián Andres 
Published: April 2020

Introducción: Los cambios en los paradigmas organizacionales a previsto de que las organizaciones deben de estudiar más a fondo el desarrollo de su talento humano con el fin de atraer, retener y mantener al mejor equipo que le permitan generar una ventaja competitiva frente al mercado, es así que se torna imperativo el estudio de las tendencias en gestión del talento humano y por ello se busca identificar y analizar la importancia y aplicabilidad de las tendencias del talento humano que están predominando en el mercado. Metodología: se realizó una investigación de tipo descriptivo con corte transversal y enfoque cuantitativo, se realizó análisis bibliográfico y encuestas semi-estructuradas a los empresarios del sector privado del municipio de Florencia. Resultados: se identificó que la gestión humana en las empresas privadas deben focalizar su accionar en los pilares Administración del talento humano, Desarrollo del talento humano, Relaciones laborales y Calidad de vida laboral y potencializadas con las tendencias de las seis dimensiones centrales que son: Diseño Organizacional, Liderazgo, fuerza laboral, cultura organizacional y captación del talento humano, las cuales representan retos en las organizaciones dado su especificidad y contribución a la gestión humana.
Analisis Postur Kerja Manual Material Handling Pada Aktivitas Pemindahan Pallet Dengan Menggunakan Metode Biomekanika Rula (STUDI KASUS : PT. ALAM PERMATA RIAU)
Authors: Siska Merry 
Published: April 2020

Indonesia merupakan negara berkembang yang banyak sekali ditemukan industri-industri dengan proses kerja masih manual dan menggunakan tenaga manusia atau disebut juga dengan Manual Material Handling (MMH). MMH banyak digunakan di dunia industri karena aktivitas MMH lebih murah dan lebih mudah dilakukan. Akan tetapi aktivitas MMH juga memiliki resiko kecelakaan kerja yang tinggi, yaitu apabila dilakukan dengan cara yang salah. PT. Alam Permata Riau merupakan sebuah perusahaan yang bergerak dibidang produksi pallet, dimana pada perusahaan ini masih ditemukan pekerjaan pengangkutan yang masih manual. Tujuan penelitian ini yaitu untuk mengindentifikasi dan menganalisis postur kerja pekerja pengangkut pallet di PT. Alam Permata Riau dari sisi biomekanika berdasarkan metode RULA. Berdasarkan hasil pengolahan dan analisa data terhadap 10 postur tubuh operator didapatkan hasil sebagai berikut: Postur tubuh pertama, ke tiga, ke lima, ke enam, ke tujuh, dan ke sembilan dengan skor akhirnya yaitu 4 dan nilai action level 2, artinya yaitu kondisi ini berbahaya sehingga pemeriksaan dan perubahan diperlukan dengan segera saat itu juga. Postur tubuh ke dua, ke delapan, dan ke sepuluh dengan skor akhir 4 dan action level 2, artinya yaitu aktivitas ini memerlukan pemeriksaan lanjutan dan juga memerlukan perubahan-perubahan terhadap postur tubuh tersebut. Postur tubuh ke empat dengan skor akhir 2 dan action level 1, artinya postur ini bisa diterima jika tidak dipertahankan atau tidak berulang dalam periode yang lama. Kata kunci : Biomekanika, Manual Material Handling, Postur Tubuh, RULA
Penerapan Green Computing Pada Fakultas Sains dan Teknologi UIN Sunan Ampel Surabaya
Authors: Syahputri Trisha Aida , Amrozi Yusuf 
Published: April 2020

Semakin berkembangnya teknologi, maka akan memberikan dampak pada lingkungan sumber daya alam. Apabila tidak membatasi penggunaan dari teknologi tersebut, akan memberikan dampak yang cukup besar bagi sumber daya alam. Green Computing merupakan langkah yang tepat untuk mengurangi emisi CO2 secara efektif. Fakultas Sains dan Teknologi pada UINSA merupakan fakultas yang memiliki komputer cukup banyak sedang mencoba untuk menerapkan teknologi Green Computing pada laboratoriumnya. Makalah ini membahas tentang beberapa hal yang perlu dilakukan sekaligus manfaat dan cara penerapan Green Computing dalam dunia pendidikan juga akan membahas tentang hal yang dilakukan oleh Fakultas SAINTEK UINSA untuk menerapkan teknologi Green Computing. Kata Kunci: Green Computing, Green ICT, Global Warming
Our people, our food, our planet
Authors: Conn Cath , Cammock Radilaite , Ford Katrina , Faesen Kloet Gloria , Nayar Shoba 
Published: April 2020

Video link: Our people, our food, our planet: Sustainable food systems policy in the Pacific
Pacific Island Countries and Territories are facing a health crisis with non communicable diseases (NCDs) currently accounting for more than 80% of deaths. In the 21st century, advances in health intervention and policy render this figure unacceptable. Multiple risk factors contribute to the NCD crisis; a leading driver being obesity due to changing dietary practices arising from the global food system. A system which is dominated by processed foods high in starch and sugars. This situation is compounded by changes in the natural and built environments relating to climate change. Tackling this issue is beyond the sole domain of public health and is, therefore, more suited to a planetary health approach. This paper applies a sustainable food systems approach to analysing NCD policy developments in the Pacific region. In particular, three domains of policy which impact diets in the Pacific are examined: food production, climate change and sustainability, and trade. It is argued that countering the NCD crisis demands a global multisectoral approach, with governments leading the way, to develop integrated policy and interventions that will secure the future wellbeing and protection of our people, our food, our planet.
La lógica del crimen: Patricia Highsmith
Authors: Ramón Arana José 
Published: April 2020

ResumenDesde la perspectiva de una teoría de la acción hay tres tipos de narrativa criminal: la del detective, que busca la aclaración de un asesinato y en la que el lector se identifica con el detective; la de la víctima, que está aún por escribir, la del criminal: es la de Patricia Highsmith, en donde asistimos a la comisión del crimen. Se estudia su lógica (un crímen lleva siempre a otro crímen)., la función de la cotidianidad, los problemas de la identidad, el sexo, la corrupción, y la dificultad de la identificación del lector con alguno de los componentes de la novela.PALABRAS CLAVEHIGHSMITH-CRIMEN-CORRUPCIÓN-IDENTIDADABSTRACTFrom the perspective of an action - theory, there are three types of criminal narrative: the one from the detective´s point of view, which searches the clarifiction of the murder; the one from the victim´s point of view, which has not been written jet; the one from the criminal: the one of Patricia Highsmith, in which we are present at the murder scene. We study his logic (one murderleads to another), the function of the everyday life, the problems of identity, sex, corruption and difficulties for the reader to be identified with any of the components of the novel. KEYWORDSHIGHSMITH-CRIME-CORRUPTION-INDENTITY
Aprendizaje-servicio en educación física: un modelo de implementación en educación superior
Authors: Franco-Sola M , Figueras S 
Published: April 2020

La finalidad de esta propuesta es presentar un modelo de implementación de la metodología docente de Aprendizaje-servicio (ApS) para favorecer la formación de estudiantes del grado universitario de Educación Primaria en la Facultad de Psicología, Ciencias de la Educación y del Deporte (FPCEE) Blanquerna, Universidad Ramon Llull (URL). Se muestra el procedimiento ApS así como su conveniencia para favorecer competencias docentes relacionadas con habilidades de aprendizaje, como trabajo en equipo o innovación, y con habilidades de desarrollo personal, como respeto a las diferencias sociales o responsabilidad comunitaria. Estas habilidades docentes son presentadas por Framework for 21st Century Learning (Partnership for 21st Century Learning, 2019) y, a su vez, se hallan estrechamente conectadas con la misión que debe labrar la universidad en relación a su responsabilidad y compromiso social. Dicha experiencia se centra en estudiantes que, desde la materia obligatoria “Educación a través del cuerpo y del movimiento”, cursada por todo el alumnado de primer curso, diseñan propuestas didácticas de Educación Física que cumplen con principios inclusivos y cooperativos tanto desde su fundamentación teórica como desde la práctica. El diseño de estas actividades es supervisado desde la universidad y la entidad receptora del servicio: el centro hospitalario Instituto Guttmann. Finalmente, se llevan a cabo en las instalaciones hospitalarias con alumnado de escuelas ordinarias donde tienen algún niño o niña con escasa movilidad y diversidad funcional. Las conclusiones y valoraciones de este ApS por parte de los estudiantes universitarios son positivas ofreciendo así una experiencia enriquecedora para fortalecer la personalidad y profesionalidad de los futuros maestros
Puzzle Plots in TV Serials: The Challenges for Enigma-Driven Storytelling in Long-Running Formats
Authors: Brütsch Matthias 
Published: April 2020

The article conducts a comparative analysis of a feature film (Open your Eyes) and two TV serials (Westworld and Dark) in order to find out how well the narrative complexity characteristic of puzzle plots may work in long-running formats. Given the core constituents of the puzzle effect ‒ disorientation, confusion, and lack of knowledge ‒ the biggest challenge for its viability in a TV serial is the extra-long running time. Both Westworld and Dark prevent audience frustration by already providing partial resolutions before the season ends, and by establishing supplementary attractions of a more classical and easy-to-grasp nature, such as future-oriented suspense-questions, or entertaining intrigues and machinations involving the whole cast of protagonists. Even in the larger structure of the TV serial, puzzle elements may, then, play an important role. However, spectators’ capacities to unravel convoluted plotlines have their limits, and the final revelation of what really happened may only satisfy if the entanglements are not overly construed. Due to these high demands, puzzle plots in TV serials will likely remain a niche phenomenon.
Monumenttien muuttuvat maisemat
Authors: Laine Silja Elina , Hautamäki Ranja 
Published: April 2020

Shifting Landscapes of Monuments – Mannerheim Statues in Tampere, Seinäjoki, Mikkeli, Lahti and Helsinki
The article sets out to look at the statues of C. G. E. Mannerheim (1857–1951) in the cities of Helsinki, Tampere, Seinäjoki, Mikkeli and Lahti. It focuses on the landscapes of the statues and the dialogical relation between the statues and their surroundings. In all cities considered, either the statues have been moved from their original place or moving has been proposed. Statues have often been studied from a point of view of the politics of history and memory. While recognizing this, we propose that urban design has an important role in modifying the ways that statues relate to public space. Statues are not only artefacts that exist in urban space, but they also produce public urban space and hierarchy. Therefore, the article focuses on the role of urban planning and design in producing and cherishing military heritage.