bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of an Electronic Health Management Program for Patients With Cardiovascular Risk: Randomized Controlled Trial
Authors: Yun Young Ho , Kang EunKyo , Cho Young Min , Park Sang Min , Kim Yong-Jin , Lee Hae-Young , Kim Kyae Hyung , Lee Kiheon , Koo Hye Yeon , Kim Soojeong , Rhee YeEun , Lee Jihye , Min Jeong Hee , Sim Jin-Ah 
Published: October 2019

Background
In addition to medication, health behavior management is crucial in patients with multiple risks of cardiovascular mortality.

Objective
This study aimed to examine the efficacy of a 3-month Smart Management Strategy for Health–based electronic program (Smart Healthing).

Methods
A 2-arm randomized controlled trial was conducted to assess the efficacy of Smart Healthing in 106 patients with at least one indicator of poor disease control and who had hypertension, diabetes, or hypercholesterolemia. The intervention group (n=53) took part in the electronic program, which was available in the form of a mobile app and a Web-based PC application. The program covered 4 areas: self-assessment, self-planning, self-learning, and self-monitoring by automatic feedback. The control group (n=53) received basic educational material concerning disease control. The primary outcome was the percentage of participants who achieved their clinical indicator goal after 12 weeks into the program: glycated hemoglobin (HbA1c) <7.0%, systolic blood pressure (SBP) <140 mmHg, or low-density lipoprotein cholesterol <130 mg/dL.

Results
The intervention group showed a significantly higher success rate (in comparison with the control group) for achieving each of 3 clinical indicators at the targeted goal levels (P<.05). Only the patients with hypertension showed a significant improvement in SBP from the baseline as compared with the control group (72.7% vs 35.7%; P<.05). There was a significant reduction in HbA1c in the intervention group compared with the control group (difference=0.54%; P≤.05). In the intervention group, 20% of patients with diabetes exhibited a ≥1% decrease in HbA1c (vs 0% among controls; P≤.05).

Conclusions
A short-term self-management strategy-based electronic program intervention may improve clinical outcomes among patients with cardiovascular risks.

Trial Registration
ClinicalTrials.gov NCT03294044; https://clinicaltrials.gov/ct2/show/NCT03294044
The Use of Web-Based Support Groups Versus Usual Quit-Smoking Care for Men and Women Aged 21-59 Years: Protocol for a Randomized Controlled Trial
Authors: Pechmann Cornelia Ann , Calder Douglas , Phillips Connor , Delucchi Kevin , Prochaska Judith J 
Published: October 2019

Background
Existing smoking cessation treatments are challenged by low engagement and high relapse rates, suggesting the need for more innovative, accessible, and interactive treatment strategies. Twitter is a Web-based platform that allows people to communicate with each other throughout the day using their phone.

Objective
This study aims to leverage the social media platform of Twitter for fostering peer-to-peer support to decrease relapse with quitting smoking. Furthermore, the study will compare the effects of coed versus women-only groups on women’s success with quitting smoking.

Methods
The study design is a Web-based, three-arm randomized controlled trial with two treatment arms (a coed or women-only Twitter support group) and a control arm. Participants are recruited online and are randomized to one of the conditions. All participants will receive 8 weeks of combination nicotine replacement therapy (patches plus their choice of gum or lozenges), serial emails with links to Smokefree.gov quit guides, and instructions to record their quit date online (and to quit smoking on that date) on a date falling within a week of initiation of the study. Participants randomized to a treatment arm are placed in a fully automated Twitter support group (coed or women-only), paired with a buddy (matched on age, gender, location, and education), and encouraged to communicate with the group and buddy via daily tweeted discussion topics and daily automated feedback texts (a positive tweet if they tweet and an encouraging tweet if they miss tweeting). Recruited online from across the continental United States, the sample consists of 215 male and 745 female current cigarette smokers wanting to quit, aged between 21 and 59 years. Self-assessed follow-up surveys are completed online at 1, 3, and 6 months after the date they selected to quit smoking, with salivary cotinine validation at 3 and 6 months. The primary outcome is sustained biochemically confirmed abstinence at the 6-month follow-up.

Results
From November 2016 to September 2018, 960 participants in 36 groups were recruited for the randomized controlled trial, in addition to 20 participants in an initial pilot group. Data analysis will commence soon for the randomized controlled trial based on data from 896 of the 960 participants (93.3%), with 56 participants lost to follow-up and 8 dropouts.

Conclusions
This study combines the mobile platform of Twitter with a support group for quitting smoking. Findings will inform the efficacy of virtual peer-to-peer support groups for quitting smoking and potentially elucidate gender differences in quit rates found in prior research.

Trial Registration
ClinicalTrials.gov NCT02823028; https://clinicaltrials.gov/ct2/show/NCT02823028

International Registered Report Identifier (IRRID)
DERR1-10.2196/16417
A Comprehensive Review on Pharmaceutical Oral Dissolving Films
Authors: Priyanka , , Kumar Kapil , Teotia Deepak 
Published: October 2019

Oral fast dissolving films are novel approach which are used now a days due to better patient compliance, rapid dissolution, onset of action . It was designed to overcome the disadvantages of orally disintegrating tablets. This technology is now found to be more effective and convenient as comparison to conventional dosage forms . These oral films are having water soluble polymers that quickly hydrate through saliva got disintegrate and starts its effect. Now a days this formulation is found to be more beneficial for both gediatric and pediatric patients . These films have greater advantage that it bypass the first pass effect due to which it directly reaches to its maximum concentration and produces good therapeutic effect.
Keywords: Dissolution, Conventional dosage form, gediatric, pediatric.
SÍNDROME METABÓLICA E DOENÇAS PERIODONTAIS
Authors: Spezzia Sérgio 
Published: October 2019

Resumo Doenças periodontais (DPs) constituem uma doença multifatorial, infecto-inflamatória e crônica que caracteristicamente possui quadro imuno-inflamatório. Essa patologia decorre da ação de bactérias que acham-se aderidas à superfície dos dentes e que afligem os tecidos periodontais. Na síndrome metabólica (SM) convive-se com determinadas manifestações fisiopatológicas conjuntamente, são elas: dislipidemia; resistência à insulina; obesidade; hipertensão arterial; hiperinsulinemia e intolerância à glicose. O objetivo do presente artigo foi averiguar como as DPs podem influir no andamento da SM e verificar como a SM pode manifestar-se, afligindo o transcurso das DPs. SM e DP apresentam elevados níveis séricos de produtos oriundos do estresse oxidativo, nessa situação ocorre que, concomitantemente havendo inflamação pode ocorrer influência de uma doença sobre a outra. Relacionado a pacientes possuidores de ambas as doenças, DPs e SM conjuntamente, sabe-se que existe expressão de caráter inflamatório nas duas e que comumente convive-se com a presença do marcador de inflamação fator de necrose tumoral alfa. A terapia periodontal realizada em pacientes com SM e DPs pode agir, minimizando o desconforto ocasionado pelas manifestações inflamatórias das duas doenças, instaladas concomitantemente, melhorando a qualidade de vida dos pacientes doentes. Palavras-chave: Doenças Periodontais. Síndrome Metabólica. Obesidade. Resistência à Insulina. Inflamação. Keywords: Periodontal Diseases. Metabolic Syndrome. Obesity. Insulin Resistance. Inflammation.
Insulin Sensitivity and Renal Hemodynamic Function in Metformin-Treated Adults With Type 2 Diabetes and Preserved Renal Function
Authors: van Bommel Erik J.M. , Ruiter Danique , Muskiet Marcel H.A. , van Baar Michaël J.B. , Kramer Mark H.H. , Nieuwdorp Max , Joles Jaap A. , Bjornstad Petter , van Raalte Daniël H. 
Published: October 2019

OBJECTIVE
Impaired insulin sensitivity is associated with hyperfiltration (i.e., elevated glomerular filtration rate [GFR]) in adolescents with type 2 diabetes (T2D) and adults with prediabetes. Yet, these relationships are based on studies that relied on estimated GFR (eGFR), estimates of insulin sensitivity, or both. We aimed to verify the relationship between insulin sensitivity and renal hemodynamic function by gold standard methods in adults with T2D.

RESEARCH DESIGN AND METHODS
Insulin sensitivity was assessed by hyperinsulinemic-euglycemic clamp (M value) (glucose infusion rate in mg/kglean/min) and renal hemodynamic function by urinary inulin (GFR) and para-aminohippuric acid (effective renal plasma flow [ERPF]) clearances in participants with T2D without overt kidney disease. Filtration fraction (FF) (GFR/ERPF) was calculated. Relationships between insulin sensitivity and renal hemodynamic parameters were examined by multivariable linear regression. Renal hemodynamic parameters were examined across tertiles of M values.

RESULTS
We tested 44 adults with T2D, of whom 77% were male, with mean ± SD age 63 ± 7 years, BMI 31.2 ± 4.0 kg/m2, and HbA1c 7.4 ± 0.6%. Average GFR was 110 ± 26 mL/min, with an FF of 22.1 ± 2.8% and median 24-h urinary albumin excretion of 11.3 mg (interquartile range 5.8–17.0). Average M value was 5.6 ± 2.9 mg/kglean/min. Insulin sensitivity inversely correlated with GFR (r = −0.44, P &lt; 0.01) and FF (r = −0.40, P &lt; 0.01), and these associations remained significant after multivariable adjustments for age, sex, renin-angiotensin system inhibitor use, and HbA1c. In addition, GFR, FF, and urinary albumin excretion were highest in the participants in the lowest M value tertile.

CONCLUSIONS
For the first time, we demonstrate that impaired insulin sensitivity is associated with intrarenal hemodynamic dysfunction by gold standard techniques in adults with T2D treated with metformin monotherapy.
Negocios para la creación de una empresa dermatológica y estética
Authors: Sánchez-Hidalgo Luis Danilo , Pontiles-García Ilmara Alejandra 
Published: October 2019

El estudio documental es el tipo de investigación que se escogió para el desarrollo de este artículo, en él, se refiere como los autores han desglosado desde distintas aristas y perspectivas, los temas de investigación relacionados a la implementación de un plan de negocio para la creación de una empresa dermatológica-estética. Para ello fueron revisados y analizados, textos, libros y trabajos de autores, como, Fleitman (2000), Vega (2005), Moreno, (2016), Boveda (2015), Liksenberg (2009), Sosa (2015), Ogliastri (2017). En cuanto a la metodología, fue asumida la investigación documental, definida por Morales, (2000) “Como, el proceso de investigación documental se dispone, esencialmente, de documentos, que son el resultado de otras investigaciones, de reflexiones de teóricos, lo cual representa la base teórica del área objeto de investigación, el conocimiento se construye a partir de su lectura, análisis, reflexión e interpretación de dichos documentos”, de igual manera este artículo presenta una investigación de tipo descriptiva, la cual fue definida, según Hernández, Fernández y Baptista (2006).De la observación, se dedujo que un plan de negocio integral les permite identificar y analizar todos los factores que deben tenerse en cuenta, al momento de poner en marcha un negocio, tales como el presupuesto, el marketing, la planificación, el estudio de mercado, entre otros, tener en claro todos estos elementos, conllevan con seguridad al logro de los objetivos planteados. Por ello en las conclusiones se menciona que no se debe poner en marcha ningún tipo de negocio, sin antes realizar un análisis profundo y exhaustivo en donde confluyan todos los elementos mencionados anteriormente en un plan de negocio
Implementasi Deep Learning berbasis Keras untuk Pengenalan Wajah
Authors: Santoso Aditya , Ariyanto Gunawan 
Published: October 2019

Sistem pengenalan wajah merupakan aspek penting dalam bidang computer vision yang mendukung terhadap perkembangan teknologi yang serba canggih seperti era sekarang ini. Penggunaan wajah sendiri digunakan karena wajah memiiki keunikan dan merupakan identitas bagi setiap manusia. Dalam pengembangannya, sistem pengenalan wajah masih memiliki permasalahan dalam faktor pencahayaan, ekpresi wajah dan perubahan atribut pada wajah. Sehingga, dalam penelitian ini penulis menggunakan Convoutional Neural Network(CNN) untuk mencoba mengatasi hal tersebut. CNN merupakan bagian dari deep learning yang digunakanuntuk melakukan proses pembelajaran pada komputer untuk mencari reprentasi terbaik. CNN terdiri 3 tahapan, yaitu Input data , Feature Learning, dan Classification. Setiap data masukan akan melaui ketiga tahapan tersebut dengan proses filtering. Pengimplementasian CNN pada penelitian ini menggunakan library keras yang menggunakan bahasa pemrograman python . Keras merupakan framework yang dibuat untuk mempermudah pembelajaran terhadap komputer.Dataset yang digunakan pada penelitian ini adalah face94 dengan mengambil 10 subject face pria. Proses pelatihan CNN dengan menggunakan data ukuran 28x28 px dengan 7 lapisan menghasilkan akurasi yang lebih baik dibandingkan dengan menggunakan 5 lapisan dengan selisih hasil 8,0 % pada saat pengujian. penggunaan 7 lapisan pada saat pengujian terhadap data testing memperoleh hasil yang baik dengan tingkat akurasi mencapai 98.57%.
Desain Prototipe Kompor Listrik Tenaga Surya
Authors: Asyari Hasyim , Umar Umar , Irawan Angga Purna 
Published: October 2019

Pemakaian bahan bakar yang bersumber dari fosil setiap tahunnya mengalami peningkatan drastis seiring bertambahnya jumlah penduduk. Bahan bakar fosil semakin menipis stoknya sehingga para peneliti mengkaji penggunaan bahan bakar yang bersifat terbarukan, sebagai upaya mengganti bahan bakar fosil dan gas. Indonesia sendiri pemanfaatan energi terbarukan saat ini belum optimal dalam menunjang kebutuhan masyarakat. Salah satu energi terbarukan yang dapat dimanfaatkan yakni energi matahari yang akan diaplikasikan pada kompor listrik. Saat ini proses untuk memasak oleh masyarakat secara umum masih menggunakan bahan bakar fosil dan gas. Tujuan peneliti ini adalah mendesain prototype kompor listrik berbasis energi terbarukan berupa sel surya. Metode yang digunakan oleh dalam penelitian ini yakni mendesain kompor listrik yang tersusun atas 3 buah glow plug dan sebuah kawat nikelin (berdiameter 1 mm) yang memiliki daya hantar tegangan yang tinggi dengan inputan sumber energi yang memanfaatkan 4 buah panel surya dengan kapasitas masing-masing 120 Wp yang disusun secara paralel. Hasil penelitian yang menunjukkan bahwa kompor listrik hasil desain dapat dimanfaatkan menggoreng sebiji telur dengan waktu 4 menit, dengan besaran arus yang mengalir 19.02 A, pada kondisi tegangan 17.0 V. Suhu panasnya berkisar pada angka 60ᴼC.
Sistem Informasi Pelanggan pada Bengkel Marno Jaya Motor
Authors: Fitri Khilyatin Ulin , Fatmawati Azizah 
Published: October 2019

Sistem informasi pelanggan digunakan untuk membantu perusahaan dalam mengelola data setiap pelanggan yang ada baik itu yang baru ataupun lama. Seperti yang dialami pada Marno Jaya Motor yaitu terhambatnya proses pencarian data terhadap pelanggan lama ataupun dalam proses menambahkan data pada pelanggan lama dikarenakan masih dilakukan secara manual meskipun sudah menggunakan bantuan aplikasi yaitu Microsoft Excel dan Microsoft Word. Bahkan masih menggunakan media kertas sebagai tempat penyimpanan data yang menyebabkan banyak waktu terbuang karena harus mencari dan memilah terlebih dahulu satu persatu. Tujuan penelitian ini adalah ingin mengembangkan sistem informasi pelanggan yang akan membantu kinerja Marno Jaya Motor dalam mengelola data setiap pelanggannya. Metode yang digunakan dalam pengembangan sistem informasi ini adalah metode wawancara, metode observasi, metode dokumentasi dan metode waterfall yang meliputi analisis kebutuhan, desain, pemrograman, uji coba, dan implementasi. Hasil dari pengembangan berupa sistem informasi pelanggan pada bengkel Marno Jaya Motor dapat membantu karyawan dalam mengelola data dengan waktu yang efektif dan efisien. Berdasarkan pengujian black box, sistem dapat berjalan sesuai dengan fungsinya. Sedangkan hasil pengujian kuisioner memperoleh presentase 90% sesuai dengan harapan awal perancangan.
Pembuatan Game Edukasi Tata Surya dengan Construct 2 berbasis Android
Authors: Nuqisari Rina , Sudarmilah Endah 
Published: October 2019

Tata surya adalah sekumpulan dari beberapa benda langit yang terdiri dari matahari sebagai pusatnya serta semua benda yang terkait dengan gaya gravitasinya. Objek tersebut merupakan planet, meteor, asteroid dan lainnya. Banyak benda yang mengitari matahari, dan salah satunya yang terpenting adalah planet. Planet yang ada ditata surya berjumlah delapan, dengan masing-masing memiliki ukuran yang berbeda-beda dengan orbit yang berbeda, oleh karena itu banyak orang yang terkadang salah untuk membedakan antara satu planet dengan planet yang lainnya. Pembelajaran tentang tata surya perlu diterapkan sejak dini, oleh karena itu pembelajaran tata surya tercantum dalam kurikulum materi pada sekolah dasar. Perkembangan teknologi yang semakin meningkat akan memudahkan pembelajaran, yaitu dengan adanya game edukasi. Banyaknya game edukasi saat ini akan memudahkan untuk menyampaikan materi pembelajaran dengan metode yang menyenangkan. Oleh karena itu, maka peneliti bertujuan untuk merancang dan menciptakan game edukasi tata surya. Pembuatan game dilakukan dengan menggunakangame engine Construct 2, dengan metode yang digunakan yaitu waterfall. Dengan adanya game edukasi ini diharapkan dapat membantu pembelajaran siswa dalam memahami materi tentang tata surya.
Optimal Power Flow Menggunakan Metode Interior Point yang Disempurnakan
Authors: Budiman Aris 
Published: October 2019

Permasalahan OPF terdiri dari banyaknya objective function, an/ara lain economic dispatch, perencanaan VAR, dan juga minimisasi rugi-rugi. Untuk perencanaan VAR perlu mempertimbangkan biaya operasional rugi-rugi, sehingga membentuk sua/u permasalahan perencanaan dan operasiyang simultan.Di tulisan ini secara khusus hanya membahas metode OPF ImprovedQuadratic Interior Point (IQIP). Metode !QIP ini memiliki unjuk kerja yang secara umum lebih baik dibanding me/ode generasi sebelumnya, yaitu EQJP (Extended Quadratic Interior Point), antara lain karena bisa menggunakan titik awal general dan pada beberapa pengujian lebih cepat konvergen dibandingkan EQJP. Hal ini menyebabkan me/ode IQIP mampu menawarkan perbaikan besar di dalam kecepatan,keakuratan, dan konvergensi di dalam pemecahan masalah optimisasi yang multi• objective function dan multi-constraint. Kemampuan memecahkan optimisasi global dari sistem terinterkoneksi dan sis/em terpartisi untuk optimisasi /oka/juga lebih baik dari generasi sebelumnya.Metode ini telah melalui pengujian terhadap sis/em 14 bus, 30 bus, dan 118 busIEEE. Efektivilas dari metode ini telah dieva/uasi dengan cara dibandingkan denganprogram OPF yang berbasis EQIP (Extended Quadratic Interior Point) dan programMINOSyang cukup dikenal di dunia perencanaan sis/em
Capital Structure and the Shareholder Value of Commercial Banks in Nigeria
Authors: Binaebi Bariweni , Frank Bingilar Paymaster 
Published: October 2019

This research paper evaluated the effect of capital structure on the shareholders' value of commercial banks in Nigeria. Data for the study was collected from the annual financial statement of ten (10) commercial banks for a period of nine (9) years spanning 2009 to 2017. The Panel least square regression method was utilized as the method of data analyses. From the results recorded, it was shown that there is a negative and non-significant relation between leverage ratio and the earnings per share of commercial banks in Nigeria. The findings also showed that there is a positive but non-significant relationship between leverage ratio and the dividend payout. From the findings, it it concluded that gearing has a negative effect on the shareholders value of commercial banks in Nigeria. This manifests in reduced profitability which by extension leads to reduction in earnings to shareholders. However, this may not lead to reduction in dividend payout to shareholders as new debt financing will likely mean that more of the earnings will be distributed as dividends as opposed to being retained in the business since debt has filled the financing gap. Drawing from the above, we conclude that commercial banks in Nigeria do not operate optimal capital structures. It is our recommendation that banks conduct an in depth study of their capital mixes in order to understnad how best to optimze their capital structures for better performance in the future.
Influence of Emergent Strategic Management Mode on Performance of Small and Medium Enterprises in Machakos Town, Kenya
Authors: Osinde Truphena Nyang'ara , Arasa Robert , Kinyili Jacinta Munyiva 
Published: October 2019

The objective of the study was to investigate influence of emergent strategic management mode on performance (sales) of SMEs in Machakos Town, Machakos County. Descriptive research design was employed to ensure a complete description of the situation of SMEs performance in Machakos town. The target population was 16,399 licensed SMEs in Machakos Town.These SMEs where grouped into eight categories.Using stratified random sampling method,a sample of 390 respondents was selected from the target population.Data was collected using questionnaires design to obtain accurate information from respondents. Collected data was analyzed using both qualitative and quantitative techniques. Due to non-normality and non-homogeneity of the dependent variable,a non-parametric test (Mann-Whitney U test) was prefered instead of a parametric test (t-test).Under this test,the data was categorized into low users of each strategy and high users of each strategy. The findings were presented using tables, figures, pie charts and graphs.The results indicated that SMEs which applies emergent strategy practices tend to have higher performance.Thus we conclude that emergent strategy practices positively influence performance of SMEs in Machakos Town. The study findings help SMEs strengthen their operations to ensure that the SMEs have a competitive edge to match their counterparts across other counties. The study recommends the need to have owners/managers of the small and medium enterprises undertake basic business and management skills training. Training the senior managers give opportunity to learn strategic management skills which will be valuable in their daily operations.