bluuebunny/crossref_metadata_2025_split huggingface dataset:
Da tolerância festiva às intolerâncias contemporâneas: sagrados desafios do patrimônio religioso no urbano
Authors: Silva Rômulo Artur Alves da , Soares Larisse Freitas , Oliveira Christian Dennys Monteiro de 
Published: March 2020

Este trabalho propõe uma discussão sobre as representações da tolerância cultural diante da promoção das festas religiosas como bens patrimoniais nas cidades. Dessa forma o patrimônio, em escala estadual, ganha aparato jurídico das políticas públicas de fortalecimento da cultura de diversidade. Entretanto, essas políticas também sofrem por iniciativas limitadas e posturas de intolerância no uso do espaço público. A pesquisa apresentada desenvolveu-se como estudo qualitativo e documental, complementado por observações de campo, na cidade de Fortaleza (CE) e suas festividades de 15 de agosto. O patrimônio imaterial religioso, objeto central do estudo, foi demarcado pelas representações midiáticas dos grupos direta e indiretamente envolvidos nos festejos de capitais do Norte, Sul e Centro-Oeste do país. O que completou um levantamento já realizado sobre grandes cidades do nordeste e sudeste do Brasil em outra etapa do estudo patrimônio festivo das festas marianas. Como resultado desse percurso, observa-se as fragilidades do reconhecimento da festa religiosas como patrimônio. E confirma-se a percepção de que as estratégias da tolerância religiosa, diante das intolerâncias institucionais e culturais, ampliam-se conforme se efetivam os registros de salvaguarda.
Caracterização da precipitação e sua relação com a evapotranspiração de referência em municípios do Piauí
Authors: Carvalho Marcus Willame , Cortez Catharina Teixeira , Silva Adriana Conceição da , Silva Gabriela Sabrine Franca 
Published: March 2020

A precipitação é uma variável de grande importância para a agricultura, sobretudo na região Nordeste do Brasil que sofre com intensos períodos de déficit hídrico. O objetivo deste trabalho foi caracterizar a precipitação de municípios piauienses e observar a influência desta variável climática sobre a evapotranspiração de referência. Os dados históricos mensais de precipitação de 1994 a 2018 foram obtidos das estações meteorológicas do Instituto Nacional de Meteorologia (INMET) dos municípios de Bom Jesus, Parnaíba, Picos e Teresina. Realizou-se a análise exploratória das precipitações mensais, sendo obtidas, para cada mês do ano, as estatísticas: média aritmética (), desvio-padrão (s), coeficiente de variação (CV), valor mínimo (Min) e valor máximo (Max), a fim de se verificar a dispersão dos dados, bem como a representação gráfica da distribuição das médias mensais da precipitação e a relação entre a precipitação e evapotranspiração de referência (ETo) e da correlação entre os valores médios mensais de precipitação para os municípios. Os resultados evidenciam que há pouca variação entre os períodos secos e chuvosos nos diferentes municípios observados, porém há variação tanto da precipitação quanto da ETo, e que há uma relação inversa entre precipitação e evapotranspiração de referência para essa região.
El último Ortega y el horizonte del exilio
Authors: Fourmont Giustiniani Eve 
Published: March 2020

Este artículo se interroga sobre la forma en que el último Ortega y Gasset, exiliado de 1936 a 1946, vivió, percibió y teorizó su propio exilio; no sólo a través de su obra publicada, sino también de su correspondencia personal y sus notas de trabajo inéditas. Después de recorrer los principales factores condicionantes de este destierro y su significado en términos éticos, se propone una lectura de la interpretación histórica que esboza Ortega del fenómeno del exilio en sus trabajos, antes de volver sobre su definición del ensimismamiento filosófico, como metáfora de la condición exílica.
This article asks about the way in which José Ortega y Gasset, exiled from 1936 to 1946, lived, perceived and theorized his own exile; not only through his published work, but also through his personal correspondence and his unpublished work notes. After reviewing the main conditioning factors of this exile and its ethical signification, the paper proposes a reading of Ortega's historical interpretation of the phenomenon of exile as it stands out of his works, before analyzing his definition of philosophical “ensimismamiento” as a metaphor for the condition of exile.
Impacto y memoria de Ortega y Gasset en Ferrater Mora
Authors: Nieto Carlos 
Published: March 2020

En esta contribución se expone por vez primera la interpretación que José Ferrater Mora hizo de la obra del filósofo José Ortega y Gasset. Tras ofrecer una breve semblanza intelectual del pensador catalán, se estudia a continuación su correspondencia con Ortega y Gasset, analizando también todos los escritos de Ferrater sobre Ortega, para concluir que, en opinión de Ferrater Mora, Ortega y Gasset es un “pensador vivo”, que siempre vuelve.
En esta contribución se expone por vez primera la interpretación que José Ferrater Mora hizo de la obra del filósofo José Ortega y Gasset. Tras ofrecer una breve semblanza intelectual del pensador catalán, se estudia a continuación su correspondencia con Ortega y Gasset, analizando también todos los escritos de Ferrater sobre Ortega, para concluir que, en opinión de Ferrater Mora, Ortega y Gasset es un “pensador vivo”, que siempre vuelve.
Intervención terapéutica y coordinación familiar en los inicios comunicativos de un caso de atención temprana
Authors: Vidal Esteve M.ª Isabel , Peirats Chacón José 
Published: March 2020

En este estudio de caso se aborda la intervención realizada en un centro de diagnóstico y atención temprana, a una alumna de dos años con hemiparesia lateral izquierda y dificultades en la manipulación y comunicación. Aplicando a lo largo de cuatro meses el sistema de Comunicación Total de Benson Schaeffer con el apoyo del método TEACCH, se pretende superar las graves limitaciones comunicativas de la alumna. El procedimiento metodológico utilizado es mixto y las técnicas de investigación empleadas son la aplicación de un test estandarizado, la entrevista, los registros de observación y el análisis documental. A partir del test cumplimentado por la madre que establece la evaluación inicial del caso, se diseña y aplica el programa realizando registros sistemáticos, al final de la intervención se vuelve a cumplimentar y se comparan los datos conseguidos. Además, se entrevista a la cuidadora de la niña y se analiza la documentación aportada por la familia y el centro donde es atendida. Los resultados obtenidos muestran que se han logrado grandes beneficios en cuanto a aprendizaje de los signos, comunicación de necesidades, emisión de verbalizaciones y generalización en los distintos contextos, fomentando en la niña una mayor autonomía y estableciendo unas bases sólidas sobre las que poder sustentar nuevos aprendizajes.
This case study reports on an intervention undertaken at a diagnostic and early attention center with a two-year-old pupil with left lateral hemiparesis and difficulties in handling and communication. By applying for four months the Benson Schaeffer's system (Total Communication) with the support of the TEACCH method, we aimed to overcome this pupil’s serious communicative limitations. The methodological procedure used was mixed and the investigation techniques used were the application of a standardized test, interviews, records of observation and documentary analysis. From the test filled in by the mother, which established the initial evaluation of the case, the program was applied, and daily records were kept. At the end of the intervention, the test was completed again and the information was compared. In addition, we interviewed her nanny and we analyzed the documentation provided by the family and the center where she is tended. Results show clear progress on the part of the baby: learning of signs, communication of needs, emission of verbalizations and generalization in different contexts. This promoted in the baby more autonomy and established a solid base from which she will be able to sustain new learnings.
Máster de secundaria: análisis de situación en la universidad española
Authors: López Ramos Víctor , Yuste Tosina Rocío , Urkidi Elorrieta Pello , Losada Iglesias Daniel 
Published: March 2020

Este artículo pretende dar respuesta a la preocupación surgida en la Conferencia de Decanos de Educación de las Universidades españolas sobre la implantación y desarrollo del Máster que habilita para la profesión docente en la enseñanza secundaria. Hemos tratado de aportar datos que sirvan como mapa de situación acerca de la realidad de estos estudios y las diferencias en su implantación. El trabajo se ha elaborado a partir de las respuestas obtenidas a un cuestionario que cumplimentaron 35 universidades, de las 72 que imparten el Máster en España. Los resultados muestran una gran heterogeneidad, principalmente, en cuatro aspectos: la oferta de plazas y de especialidades, la estructura del plan de estudios, el perfil profesional del profesorado que imparte docencia en el mismo y la realización del Practicum y del Trabajo de Fin de Máster. Del estudio, se concluye la necesidad de que el Máster deba gestionarse académicamente por los centros universitarios responsables de la formación inicial del profesorado, así como la exigencia de una clarificación precisa, por parte de las agencias de evaluación, que homogenice los criterios de acreditación para el conjunto de universidades y comunidades autónomas.
This article aims to respond to the concern raised in the Conference of Deans of Education of Spanish Universities regarding the implementation and development of the Master’s Degree in Secondary Education Teacher Training. We aim to provide data that serve as a situation map about the reality of these studies and the differences in their implementation. Data were obtained through a questionnaire completed by 35 universities, of the 72 that teach this master’s in Spain. The results show a great heterogeneity, mainly in four aspects: the offer of seats and specialties, the structure of the curriculum, the professional profile of the teaching staff and the development of school trainings and master’s theses. The results highlight the need for the master’s to be managed academically by the university faculties in charge of initial teacher training, as well as the need for precise clarifications, on the part of the evaluation agencies, with a view to homogenizing accreditation processes for all universities.
Actitudes de los escolares ante la llegada de población migrante: Estudio comparativo y aproximación al desarrollo de buenas prácticas educativas
Authors: Habib Allah Mohamed Chamseddine , Hernández Martín Azucena 
Published: March 2020

Algunos estudios señalan que los grupos sociales más próximos o en contacto con población migrante pueden desarrollar prejuicios, tanto explícitos como más sutiles que los que se generan entre poblaciones en las que el contacto con miembros de otras culturas es todavía poco significativo (Retortillo y Rodríguez, 2008; Cea D’Ancona, 2009; Checa y Arjona, 2011). Este trabajo tiene como objetivos conocer qué opinan y cuáles son las actitudes de los escolares ante la llegada de migrantes a las aulas y a otros contextos cercanos. Se han comparado dichas opiniones y actitudes en dos zonas españolas con distinta trayectoria en la presencia de migrantes, Salamanca y Murcia; analizando las posibles diferencias en dichas actitudes, atendiendo también al sexo y el nivel educativo. La metodología incluye un estudio de carácter comparativo con una primera aproximación descriptiva, mediante la aplicación de un cuestionario. Los resultados indican la percepción generalizada del trato inadecuado que recibe el colectivo migrante, siendo las escolares quienes lo perciben en mayor medida. Con ciertos matices, la zona geográfica no es una variable que tenga importancia a la hora de considerar la influencia en clase de migrantes, como tampoco lo es el nivel educativo. Aunque las actitudes positivas son más frecuentes entre los escolares de Educación Primaria. El estudio finaliza apuntando algunas líneas de actuación educativa que fomenten la interacción y la convivencia positiva en el centro escolar.
Some studies point out that the social groups closer to or in contact with migrant populations may develop prejudices, both explicit and subtler than those generated between populations in which the contact with members of other cultures is still insignificant (Retortillo y Rodríguez, 2008; Cea D’Ancona, 2009; Checa y Arjona, 2011). The aim of this work is to find out what schoolchildren think about and what their attitudes are towards the arrival of migrant people to the classroom and other nearby settings. These opinions and attitudes have been compared in two Spanish areas with different trajectories in the presence of migrant people, Salamanca and Murcia. The possible differences in these attitudes were examined, also taking into account the gender and the educational level of the participants. The methodology includes a comparative study with a first descriptive approximation, via a questionnaire. The results indicate the widespread perception, especially on the part of school children, that migrant groups are inappropriately treated. With certain nuances, geographic location and educational level are not important variables when it comes to considering the influence of migrant people on the class. However, positive attitudes are more frequent among Elementary Education students. The study concludes by highlighting educational actions that promote interaction and positive coexistence in schools.
Abstract
Authors: Redaktionen - 
Published: March 2020

Torben Bech Dyrberg State and Civil Society - the Po!itica/ Constiution of the Social Order
Jacob Torfing Gramsci and the neo-Gramscians: Towards a Societal Theory of the Primacy of Politics
Uffe Østergård Clientelism as a Possible Form of the Postpolicical Society?
A preliminary study of the effect of a high-salt diet on transcriptome dynamics in rat hypothalamic forebrain and brainstem cardiovascular control centers
Authors: Ramachandran Chitra Devi , Gholami Khadijeh , Lam Sau Kuen , Hoe See Ziau 
Published: March 2020

BackgroundHigh dietary salt intake is strongly correlated with cardiovascular (CV) diseases and it is regarded as a major risk factor associated with the pathogenesis of hypertension. The CV control centres in the brainstem (the nucleus tractus solitarii (NTS) and the rostral ventrolateral medulla (RVLM)) and hypothalamic forebrain (the subfornical organ, SFO; the supraoptic nucleus, SON and the paraventricular nucleus, PVN) have critical roles in regulating CV autonomic motor outflows, and thus maintaining blood pressure (BP). Growing evidence has implicated autonomic regulatory networks in salt-sensitive HPN (SSH), but the genetic basis remains to be delineated. We hypothesized that the development and/ or maintenance of SSH is reliant on the change in the expression of genes in brain regions controlling the CV system.MethodologyWe used RNA-Sequencing (RNA-Seq) to describe the differential expression of genes in SFO, SON, PVN, NTS and RVLM of rats being chronically fed with high-salt (HS) diet. Subsequently, a selection of putatively regulated genes was validated with quantitative reverse transcription polymerase chain reaction (qRT-PCR) in both Spontaneously Hypertensive rats (SHRs) and Wistar Kyoto (WKY) rats.ResultsThe findings enabled us to identify number of differentially expressed genes in SFO, SON, PVN, NTS and RVLM; that are either up-regulated in both strains of rats (SON-Caprin2,Sctr), down-regulated in both strains of rats (PVN-Orc,Gkap1), up-regulated only in SHRs (SFO-Apopt1,Lin52,AVP,OXT; SON-AVP,OXT; PVN-Caprin2,Sclt;RVLM-A4galt,Slc29a4,Cmc1) or down-regulated only in SHRs (SON-Ndufaf2,Kcnv1; PVN-Pi4k2a; NTS-Snrpd2l,Ankrd29,St6galnac6,Rnf157,Iglon5,Csrnp3,Rprd1a; RVLM-Ttr,Faim).ConclusionsThese findings demonstrated the adverse effects of HS diet on BP, which may be mediated via modulating the signaling systems in CV centers in the hypothalamic forebrain and brainstem.
Chronic arsenate exposure affects amphipod size distribution and reproduction
Authors: Visviki Ioanna , Judge Michael L. 
Published: March 2020

Arsenate (As V) is the predominant inorganic species of arsenic in oxic aquatic environments. Chronic water quality criteria for arsenate have not been established due to the scarcity of relevant studies on its impact on aquatic biota. We examined the acute and chronic effects of arsenate on the benthic amphipod Leptocheirus plumulosus, an important test organism for ecotoxicological studies. We determined that a concentration of 1,971 µg/L arsenate induced 50% mortality (LC50) in juveniles in 96-hr water only exposure. Subsequently, we tested the efficacy of a 42-day sediment bioassay to determine chronic population-level effects. Specifically, we analyzed the survivorship, size distribution, reproduction and offspring sex ratio of this amphipod to a sublethal concentration of arsenate. The sublethal concentration was determined based on the results of the acute tests. Arsenate (500 µg/L) was added to seawater (20 psu) overlying natural sediments (particle sizes < 250 µm). Fifteen replicate chambers per treatment were employed, each stocked with 20 stage-sorted juvenile amphipods (500–600 µm). Five replicates per treatment were destructively sampled on week 3 and ten replicates were sampled on week 6. Arsenate exposure did not affect the survivorship of parental amphipods, as expected, but it decreased significantly the number of offspring in the largest size classes. By week 6, arsenate-exposed replicates had statistically fewer sexually mature offspring compared to controls, likely because the overall reproduction was suppressed. Arsenate exposed amphipods had significantly fewer offspring than controls by week 6 (9.3 vs. 19.1 per parent), but the sex ratio of the offspring was not altered. Our results indicate that size distribution and reproduction may be more sensitive endpoints than survivorship for the chronic effects of arsenate in oxic systems. The extended 42-day bioassay with Leptocheirus plumulosus is a very promising tool to study the effects of toxicants on population dynamics.
The Clinical Implication of PTEN and FAK Expression in Gastric Cancer Patients
Authors: Lai Yi-Chen , Huang Kuo-Hung , Chen Ming-Huang , Chao Yee , Lo Su-Shun , Li Anna Fen-Yau , Wu Chew-Wun , Shyr Yi-Ming , Fang Wen-Liang 
Published: March 2020

Objective:
The tumor suppressor gene phosphatase and tensin homolog (PTEN) was reported to inhibit the growth and invasion of gastric cancer (GC) via the downregulation of focal adhesion kinase (FAK). To date, the clinical implication of PTEN and FAK expression in GC has not been well addressed.

Methods:
A total of 200 GC patients receiving curative surgery were enrolled. The clinicopathologic features according to the expression of PTEN and FAK protein using immunohistochemical staining were compared among patients.

Results:
Patients with high PTEN expression were more likely to have smaller tumor size, more well- and moderately differentiated tumors, a more superficial gross appearance, less scirrhous stromal reactions, more likely to have high FAK expression, and have less advanced pathologic tumor (T) category, node (N) category, and tumor, node, metastasis (TNM) stage and more distant metastases than patients with low PTEN expression. Multivariate analysis showed that PTEN/FAK expression status is an independent prognostic factor affecting overall survival (OS) and disease-free survival (DFS). Patients with PTEN(high)/FAK(low) had better OS and DFS, followed by those with PTEN(high)/FAK(high), those with PTEN(low)/FAK(low), and those with PTEN(low)/FAK(high) (OS: 83.3% versus 58.0% versus 46.2% versus 26.5%, respectively, P &lt; 0.001; DFS: 83.3% versus 55.8% versus 30.8% versus 24.4%, respectively, P &lt; 0.001).

Conclusions:
GC patients with high PTEN expression were more likely to have fewer tumor recurrences and a better prognosis than those with low PTEN expression. PTEN and FAK may have opposing effects on GC patient survival. Our results may have clinical impact on treatment of GC patients.
Synthetic Biology and Tissue Engineering: Toward Fabrication of Complex and Smart Cellular Constructs
Authors: Hoffman Tyler , Antovski Petar , Tebon Peyton , Xu Chun , Ashammakhi Nureddin , Ahadian Samad , Morsut Leonardo , Khademhosseini Ali 
Published: March 2020

AbstractTissue engineering approaches, with the goals of replacing or recovering damaged or diseased tissues, or of reconstituting tissues in vitro for disease modeling and drug development, have the potential to make significant contributions to medicine. Advances in stem cell biology, biomaterial synthesis and characterization, and microscale technologies have made engineered tissues a reality. However, the classic tools used to build tissues in the lab do not allow for complete control of cell behaviors. More recently, synthetic biology principles have developed robust and versatile approaches to program cells with artificial genetic circuits, where cell behavior and function can be manipulated. At the interface between synthetic biology and tissue engineering, there is space for a new area of investigation where material engineering and cellular engineering complement and sustain each other. In this progress report, synthetic biology principles and how they have been used to engineer cells with potential to dictate cell behavior and function in tissue constructs of the future are briefly described. It is believed that this research area still needs further exploration to fully exploit synthetic biology to make smart and functional cellular constructs for therapeutic and in vitro applications.
Tumor‐Oriented Telomerase‐Terminated Nanoplatform as Versatile Strategy for Multidrug Resistance Reversal in Cancer Treatment
Authors: Wu Yahui , Zhong Dan , Li Yachao , Wu Huayu , Xu Xianghui , Yang Jun , Gu Zhongwei 
Published: March 2020

AbstractMultidrug resistance is one of the major problems in chemotherapy, and exploiting impactful targets to reverse drug resistance of most tumors remains a difficult problem. In this study, the tumor‐oriented nanoparticle, BIBR1532‐loaded peptide dendrimeric prodrug nanoassembly (B‐PDPN), is used to assist telomerase inhibition for multidrug resistance reversal. B‐PDPN possesses the characteristics of an acid‐activated histidine to promote cellular uptake, a redox‐sensitive poly(ethylene glycol) (PEG) layer to actualize endosomal escape and telomerase inhibitor release, and an acid sensitive chemical bond to facilitate chemotherapeutic drug release. Telomerase termination weakens the protective effect of hTERT protein on mitochondria and enhances reactive oxygen species (ROS) production, which increases DNA damage and apoptosis. The tumor‐oriented nanoparticle B‐PDPN achieves a broad‐spectrum telomerase inhibition to combat multidrug resistance. In vivo experiments support the evidence that B‐PDPN accumulates in the tumor site and reduces the expression of hTERT in tumor tissues to inhibit drug resistant tumor growth. This work introduces an innovative strategy of utilizing features of tumor‐activated nanoplatform to assist telomerase termination. The nanoplatform enhances intracellular drug concentration and nucleus delivery of doxorubicin (DOX), and promotes DNA damage to combat multidrug resistance.