bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of CD58 polymorphism and multiple sclerosis in Malaysia: a pilot study
Authors: Ching Yee Ming , Viswanathan Shanthi , Mohamed Nor Nurhanani , Shuib Shuwahida , Kamarudin Balqis , Mansor Salawati , Yusof Ainur Yusniza , Arip Masita 
Published: December 2019

AbstractBackgroundMultiple sclerosis is an immune mediated disease targeting the central nervous system. Association of non-human leukocyte antigen gene,CD58, with multiple sclerosis has been reported in several populations but is unclear among Southeast Asians. This pilot study was conducted to explore the association betweenCD58polymorphism and multiple sclerosis among the Malay population in Malaysia.MethodsBlood samples were collected from 27 multiple sclerosis patients, and compared with 58 age- and gender matched healthy individuals. All patients were tested negative for anti-aquaporin 4. DNA was extracted from the blood and genotyped for 3 single nucleotide polymorphisms rs12044852, rs2300747 and rs1335532 of geneCD58by real-time PCR.ResultsThe majority of multiple sclerosis patients were female (85.2%). The general mean age of onset was 30.5 years. Genotyping results showed that frequencies of the alleles were between 40 and 50% for MS patients and healthy individuals. Association (allelic model) between multiple sclerosis andCD58gene polymorphism alleles rs12044852 (p = 0.410), rs2300747 (p = 0.881) and rs1335532 (p = 0.407) were indistinct.ConclusionsThe impact of theCD58gene polymorphism was not prominent in this pilot study, implying that genetic composition contributing to multiple sclerosis may be different between different populations, thus results in a heterogeneity of disease manifestation and distribution.
Controlling Coordination Number of Rhodium(III) Complex by Ligand-Based Redox for Catalytic C–H Amination
Authors: Fujita Daiki , Kaga Akira , Sugimoto Hideki , Morimoto Yuma , Itoh Shinobu 
Published: December 2019

Abstract
The rhodium (III) complexes supported by a di-deprotonated o-phenylenediamido ligand, ([Cp*RhIII(C6H4N2tBu2Ph22−)] ([Cp*RhIII(L2−)], 1), and one-electron and two-electron oxidized ligands, [Cp*RhIII(C6H4N2tBu2Ph2•−)(CN)] ([Cp*RhIII(L•−)(CN)], 2) and [Cp*RhIII(C6H4N2tBu2Ph20)(CN)]+ ([Cp*RhIII(L0)(CN)]+, 3) (H2L = H2C6H4N2tBu2Ph2 = N,N-di-(3,5-di-tert-butylphenyl)benzene-1,2-diamine)), have been synthesized and characterized by 1H NMR, ESI–mass, EPR, UV-vis spectroscopic methods, and cyclic voltammetry as well as single-crystal structure analysis. In complexes 2 and 3, a cyanide ion coordinates to each rhodium(III) center to stabilize the six-coordinate structures. Catalytic activity of these complexes has been examined in the intramolecular C–H amination of trisylazide (2,4,6-triisopropylphenylsulfonyl azide) to find that complex 2 shows the highest activity. The result suggests that single-electron transfer takes place from the anion radical ligand C6H4N2tBu2Ph2•− of 2 to trisylazide to form a nitrene radical bound rhodium(III) active species for the C–H amination.
Validation of in-house knowledge-based planning model for advance-stage lung cancer patients treated using VMAT radiotherapy
Authors: Tambe Nilesh S , Pires Isabel M , Moore Craig , Cawthorne Christopher , Beavis Andrew W 
Published: December 2019

Objectives:
Radiotherapy plan quality may vary considerably depending on planner’s experience and time constraints. The variability in treatment plans can be assessed by calculating the difference between achieved and the optimal dose distribution. The achieved treatment plans may still be suboptimal if there is further scope to reduce organs-at-risk doses without compromising target coverage and deliverability. This study aims to develop a knowledge-based planning (KBP) model to reduce variability of volumetric modulated arc therapy (VMAT) lung plans by predicting minimum achievable lung volume-dose metrics.

Methods:
Dosimetric and geometric data collected from 40 retrospective plans were used to develop KBP models aiming to predict the minimum achievable lung dose metrics via calculating the ratio of the residual lung volume to the total lung volume. Model accuracy was verified by replanning 40 plans. Plan complexity metrics were calculated using locally developed script and their effect on treatment delivery was assessed via measurement.

Results:
The use of KBP resulted in significant reduction in plan variability in all three studied dosimetric parameters V5, V20 and mean lung dose by 4.9% (p = 0.007, 10.8 to 5.9%), 1.3% (p = 0.038, 4.0 to 2.7%) and 0.9 Gy (p = 0.012, 2.5 to 1.6Gy), respectively. It also increased lung sparing without compromising the overall plan quality. The accuracy of the model was proven as clinically acceptable. Plan complexity increased compared to original plans; however, the implication on delivery errors was clinically insignificant as demonstrated by plan verification measurements.

Conclusion:
Our in-house model for VMAT lung plans led to a significant reduction in plan variability with concurrent decrease in lung dose. Our study also demonstrated that treatment delivery verifications are important prior to clinical implementation of KBP models.

Advances in knowledge:
In-house KBP models can predict minimum achievable lung dose-volume constraints for advance-stage lung cancer patients treated with VMAT. The study demonstrates that plan complexity could increase and should be assessed prior to clinical implementation.
Ultrasound-guided caudal epidural steroid injection in chronic radicular low back pain: short-term electrophysiologic benefits
Authors: Ibrahim Maha Emad , Awadalla Magdy Ahmed , Omar Aziza Sayed , al-Shatouri Mohammad 
Published: December 2019

Objective:To assess the short-term efficacy of ultrasound-guided caudal epidural steroid injections (ESIs) in improving pain, and nerve function as measured by electrophysiological testing in chronic radicular low back pain.Methods:Patients diagnosed with chronic radicular low back pain were randomized into one of two groups. The injection group (n = 20) underwent a single ultrasound-guided Caudal ESI of 1 ml of 40 mg ml−1Triamcinolone Acetonide (Kenacort-A), with local anesthetic. The control group (n = 20) underwent a 12-session physiotherapy program. Both groups were evaluated before and 2 weeks after the intervention using visual analog scale for pain and electrophysiological testing comprising peroneal and tibial terminal motor latencies and F-response latencies and chronodispersion.Results:Both groups showed significant pain reduction on the visual analog scale after the intervention. The injection group showed a significant reduction in F wave chronodispersion post-treatment (<0.01). In the control group, there were no significant differences in F wave parameters pre- and post-treatment (p > 0.05).Conclusion:Caudal ESIs were shown to provide short-term improvement of nerve function as evident by improvement in the electrophysiological parameters sensitive to radiculopathy. It was found to be superior to standard physical therapy in this regard.Advances in knowledge:This work shows a novel electrophysiologic evidence of the short-term efficacy ultrasound-guided caudal ESI.
Mandibular radiomorphometric parameters of women with cemento-osseous dysplasia
Authors: Kato Camila NAO , Barra Sâmila G , Pereira Mateus JC , Gomes Lucas TF , Amaral Tânia MP , Abreu Lucas G , Brasileiro Cláudia B , Mesquita Ricardo A 
Published: December 2019

Objective: To compare the radiomorphometric parameters of mandibular trabecular and cortical bone of females with and without cemento-osseous dysplasia (COD). Methods A retrospective cross-sectional paired study was conducted. Digital panoramic radiographs were obtained from females diagnosed in a public service of Oral Medicine. The participants were divided into two groups of 50 subjects each: females with a diagnosis of COD (COD group) and females without a diagnosis of COD (non-COD group), randomly chosen from the image database and paired for age. The radiomorphometric parameters analyzed were: mandibular cortical width (MCW), fractal dimension (FD) and mandibular cortical index (MCI). The paired t-test and Wilcoxon test were used to compare MCW and FD values and the McNemar-Bowker test compared the MCI. Results The mean age of both groups was 46.84 ± 11.38 years. The median MCW index was 3.12 mm (2.15–4.55) for the COD group and 3.52 mm (1.90–4.70) for the non-COD group (p = 0.034). The mean FD value of the COD group (1.2039 ± 0.0926) was lower than that of the non-COD group (1.2472 ± 0.0894) in the anatomical region of the interest of mandibular cortical bone (p = 0.031), while no difference was detected in alveolar trabecular bone. The C3 degree of MCI was more frequent in the COD group (p = 0.009). Conclusion: Females with COD had lower values of radiomorphometric parameters in mandibular cortical bone than females of the same age without COD. These results suggest that, in addition to the dental care recommended in the literature, COD females also require more attention and screening for low bone mineral density.
LA MEMORIA COMO BOOMERANG ¿QUÉ QUEDA DEL CORDOBAZO?
Authors: SERVETTO ALICIA , ORTIZ LAURA 
Published: December 2019

La conmemoración de los 50 años del Cordobazo es una oportunidad para revisar su historia, las condiciones que lo hicieron posible y las consecuencias que produjo. También es una ocasión para examinar la(s) memoria(s), debatir sobre sus significados en el presente y ensayar respuestas a la no siempre cómoda pregunta acerca de ¿Qué queda del Cordobazo? Como volverse sobre un espejo roto, la pregunta despliega antiguas cuestiones revisadas con lecturas actuales, y nuevos interrogantes que abren viejas discusiones: ¿Fue el Cordobazo una respuesta del movimiento obrero a la política conómica de Krieger Vasena que atentaba contra los salarios y condiciones laborales? ¿Fue el Cordobazo la culminación de una etapa de luchas y resistencia iniciada en 1955? o ¿Fue el inicio de un nuevo ciclo marcado por la politización y la radicalización ideológica?, ¿Se trató de una gesta sólo de hombres?, ¿Resultaba una novedad el activismo y la participación de los estudiantes y los jóvenes? Desandar cada una de estas preguntas nos obliga a pensar críticamente el pasado, sin caer en la tentación solo de rememorar o, en su defecto, de hacer de aquel acontecimiento un mito de la gesta popular. Por el contrario, se trata de actualizar y analizar ese pasado que vuelve y nos interpela con preguntas, con paradojas y con contradicciones.
The Influence of Self-Employment on Early-Stage Entrepreneurship in Romania. A Global Entrepreneurship Monitor-Based Analysis
Authors: Györfy Lehel , Madaras Szilárd 
Published: December 2019

Abstract
The self-employment occupational status has a determinant role in the entrepreneurship development, including generally almost all sectors of the national economy. In this paper, we will focus on this topic. The statistical analysis of this occupational status and its implications on entrepreneurship in Romania in 2015 were considered based on the INSE statistical database, followed by an analysis based on a GEM 2015 (Global Entrepreneurship Monitor) database regarding the main factors influencing early-stage entrepreneurship. To describe the start-up intention and start-up effort, setting out from the literature, we included a set of indicators into the logistic regression analysis as follows: age, income, gender, education, working status, existence of entrepreneur acquaintances, confidence in one’s own knowledge, skill, and experience, completing the set with the presence of self-employment, as new research suggests it.
Signal and error assessment of GOCE-based high resolution gravity field models
Authors: Gruber T. , Willberg M. 
Published: December 2019

Abstract
The signal content and error level of recent GOCE-based high resolution gravity field models is assessed by means of signal degree variances and comparisons to independent GNSS-levelling geoid heights. The signal of the spherical harmonic series of these models is compared to the pre-GOCE EGM2008 model in order to identify the impact of GOCE data, of improved surface and altimetric gravity data and of modelling approaches. Results of the signal analysis show that in a global average roughly 80% of the differences are due to the inclusion of GOCE satellite information, while the remaining 20% are contributed by improved surface data. Comparisons of the global models to GNSS-levelling derived geoid heights demonstrate that a 1 cm geoid from the global model is feasible, if there is a high quality terrestrial gravity data set available. For areas with less good coverage an accuracy of several centimetres to a decimetre is feasible taking into account that GOCE provides now the geoid with a centimetre accuracy at spatial scales of 80 to 100 km. Comparisons with GNSS-levelling geoid heights also are a good tool to investigate possible systematic errors in the global models, in the spirit levelling and in the GNSS height observations. By means of geoid height differences and geoid slope differences one can draw conclusions for each regional data set separately. These conclusions need to be considered for a refined analysis e.g. to eliminate suspicious GNSS-levelling data, to improve the global modelling by using full variance-covariance matrices and by consistently weighting the various data sources used for high resolution gravity field models. The paper describes the applied procedures, shows results for these geoid height and geoid slope differences for some regional data sets and draws conclusions about possible error sources and future work to be done in this context.
Association between neck circumference and non-alcoholic fatty liver disease in Mexican children and adolescents with obesity
Authors: Peña-Vélez Rubén , Garibay-Nieto Nayely , Cal-y-Mayor-Villalobos Manuel , Laresgoiti-Servitje Estibalitz , Pedraza-Escudero Karen , García-Blanco María del Carmen , Heredia-Nieto Omar Alfonso , Villanueva-Ortega Eréndira 
Published: December 2019

Abstract

Background
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic hepatic disorder in the pediatric population and has grown along with the obesity pandemic in which we live today. Adipose tissue storage in the upper body segment has been positively correlated with visceral adiposity and metabolic disease, which suggests that neck circumference could represent an easily accessible and replicable anthropometric measurement to identify patients with a higher risk of developing NAFLD. The main purpose of this study is to determine if there is an association between neck circumference and NAFLD. The secondary objectives are to establish cutoff values based on gender and puberty staging.

Methods
We included a sample pediatric population of 112 patients diagnosed with obesity aged between 6 and 18 years. We performed anthropometric and metabolic measurements on every patient, and NAFLD diagnosis was determined with hepatic ultrasound.

Results
The neck circumference was larger in NAFLD pediatric patients compared to those without NAFLD (p = 0.001). In a multivariate analysis, the neck circumference was associated with NAFLD as an independent risk factor (odds ratio [OR] = 1.172; 95% CI = 1.008–1.362; p = 0.038). Tanner 2–3 = 35 cm and Tanner 4–5 = 38 cm were established as risk cutoff values to develop NAFLD in the male adolescent population.

Conclusions
There is an association between the neck circumference and NAFLD in pediatric patients with obesity, particularly in the male population.
The Self and Others: Revisiting Information Needs and Libraries as Public, Social Institutions in a Post-truth World
Authors: Oliphant Tami 
Published: December 2019

Abstract
The post-truth era and the increasing ease with which fake news is disseminated and consumed is a wicked problem that invites re-examination of the media environment, algorithmic authority, library and information science (LIS) professional practice, and what people bring to information interactions in terms of cognitive biases and worldviews. Fake news has social consequences such as undermining civic discourse and democracy, and inciting hatred. Consequently, the role of libraries as public, social institutions embedded in democratic societies and the relational aspects of information needs are important to consider. An alternative framework, the decent society, a society in which its attendant social institutions do not humiliate, is explored. An example from the Toronto Public Library (TPL) is used to illustrate the ways in which a social institution can uphold the principle of non-humiliation in an increasingly politicized world.
TGF-β Prodomain Alignments Reveal Unexpected Cysteine Conservation Consistent with Phylogenetic Predictions of Cross-Subfamily Heterodimerization
Authors: Wisotzkey Robert G , Newfeld Stuart J 
Published: December 2019

Abstract
Evolutionary relationships between prodomains in the TGF-β family have gone unanalyzed due to a perceived lack of conservation. We developed a novel approach, identified these relationships, and suggest hypotheses for new regulatory mechanisms in TGF-β signaling. First, a quantitative analysis placed each family member from flies, mice, and nematodes into the Activin, BMP, or TGF-β subfamily. Second, we defined the prodomain and ligand via the consensus cleavage site. Third, we generated alignments and trees from the prodomain, ligand, and full-length sequences independently for each subfamily. Prodomain alignments revealed that six structural features of 17 are well conserved: three in the straitjacket and three in the arm. Alignments also revealed unexpected cysteine conservation in the “LTBP-Association region” upstream of the straitjacket and in β8 of the bowtie in 14 proteins from all three subfamilies. In prodomain trees, eight clusters across all three subfamilies were present that were not seen in the ligand or full-length trees, suggesting prodomain-mediated cross-subfamily heterodimerization. Consistency between cysteine conservation and prodomain clustering provides support for heterodimerization predictions. Overall, our analysis suggests that cross-subfamily interactions are more common than currently appreciated and our predictions generate numerous testable hypotheses about TGF-β function and evolution.
GASTROMİLLİYETÇİLİK ve GASTRODİPLOMASİ KAVRAMLARI ÜZERİNE BİR DEĞERLENDİRME
Authors: BUCAK Turgay , YİĞİT Serkan 
Published: December 2019

Toplum içerisinde farklı dil ve lehçeler konuşulsa bile,
toplum bilinci için bazı ortak değerler bulunmaktadır. Bu değerler, toplum için
ortak dil özelliği gösterebilmektedir. Ulusal mutfak kültürü de, toplumlar için
ortak bir dil görevi görmektedir. Bu bağlamda, mutfak kültürüne ait herhangi
bir yemeğin hazırlanması, insanlarda milli duyguların tetiklenmesine neden olmaktadır.
Gastromilliyetçilik kavramının temelleri,
bu noktada ortaya çıkmaktadır. Gastromilliyetçilik kavramının en temel
amacı, ulusal mutfağının korunmasında
milli duyguların ön planda tutularak toplum içerisinde bir bilinç uyandırmaya
çalışmaktır. Gastromilliyetçilik kavramı ile ortaya konan mutfak kültürü
değerlerinin, diğer kültürler arasında köprü oluşturması ve bu sayede etkileşim
ve tanıtım aracı olarak kullanılabilmesi ise gastrodiplomasi olarak
adlandırılmaktadır. Bu çalışmanın amacı, gastronomi literatürü için yeni iki
kavram olan; gastromilliyetçilik ve gastrodiplomasi kavramlarını tanımlayarak
ulusal mutfağın korunmasında, tanıtılmasında ve sürdürülebilir hale
getirilmesinde bu iki kavramın önemini ortaya koymaktır. Çalışma kapsamında dünyadan ve
Türkiye’den, gastromilliyetçilik ve gastrodiplomasi faaliyetlerine örnekler
verilerek değerlendirmeler yapılmıştır. Çalışmanın sonuç kısmında; bu iki
kavramın öneminden bahsedilerek, Türk mutfağının tanıtılmasında bu iki kavramın
daha fazla nasıl etkin kullanılabileceği sorusuna cevap aranmıştır. Türk mutfak kültürünün tanıtılmasında, gastromilliyetçilik ve
gastrodiplomasi faaliyetlerinin, tanıtım çalışmalarına olumlu yönde etki edeceği
sonucuna ulaşılmıştır.
Institutionalization of Mentoring as a Resource for Professional Development of Russian Teachers
Authors: Margolis Arkady , Arzhanykh Elena , Khusnutdinova Margarita 
Published: December 2019

Results of a sociological study are used to analyze the major problems of mentoring early-career educators, and arguments are provided to support statutory recognition of mentors for novice school teachers and the mentoring system as such. The study was conducted by members of the MSUPE Center for Applied Psychological and Pedagogical Research jointly with scholars from five regional universities. It involved 25 interviews with school administrators (principals and head teachers) as well as questionnaire surveys of beginning teachers (work experience of under five years, age under 30) and their experienced colleagues. The total sample consisted of 490 teachers (150 new and 430 experienced) employed with federal and municipal institutions of general education.
Findings show that the main barriers to effective mentoring include (i) novice teachers being unaware of their professional deficiencies and the need to be mentored by experts, (ii) experienced teachers being unwilling to mentor because of status, workload and pay uncertainties, and (iii) administrators paying inadequate attention to systematization of novice teacher professional adaptation.
Institutionalization is required to allow further development of the mentoring system in Russian schools. Statutory regulation of mentoring implies introducing relevant job positions, elaborating mentor job duties, determining the size and sources of pay, creating a system of mentor selection and training, and defining the content and major forms of mentoring programs.
EDUCAÇÃO INFANTIL ENQUANTO DIREITO: O ESTADO DA ARTE
Authors: Chamon Edna Maria Querido de Oliveira , Lacerda Pétala Gonçalves , Marcondes Nilsen Aparecida Vieira 
Published: December 2019

No contexto educacional, a garantia do direito à Educação Infantil, primeira etapa da Educação Básica, conforme prevê o artigo 29 da Lei de Diretrizes e Bases da Educação Nacional (LDB) nº 9.394/96, representa uma conquista recente. Com isso, surge o interesse pelo tema da Educação Infantil em estudos e pesquisas com a necessidade de reflexões que proporcionem conhecimentos que minimizem as lacunas existentes sobre o assunto. Para elaboração deste estudo sobre o estado da arte de natureza exploratória e descritiva, utilizou-se de categorias para análise representadas pelos seguintes descritores: educação infantil, qualidade na educação infantil e representações sociais em educação infantil. A abordagem se apresenta como bibliográfica. Neste sentido, analisou-se a literatura acerca dos estudos em Educação Infantil. A tendência da produção científica evidencia que focar questões atinentes à Educação Infantil vem se constituindo como um grande contributo na busca pelo rompimento com uma perspectiva assistencialista que marcou sua existência e trajetória.