bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase III trial of gemcitabine (30-minute infusion) versus gemcitabine (fixed-dose-rate infusion [FDR]) versus gemcitabine + oxaliplatin (GEMOX) in patients with advanced pancreatic cancer (E6201)
Authors: Poplin E. , Levy D. E. , Berlin J. , Rothenberg M. L. , O’Dwyer P. J. , Cella D. , Mitchell E. , Alberts S. , Benson A. 
Published: March 2020

LBA4004 Background: Gemcitabine (GEM) is the cornerstone of treatment of metastatic pancreatic cancer (PANCA). FDR GEM or GEMOX are promising, but have yet to convincingly demonstrate a survival advantage over GEM alone. E6201 compares overall survival (OS) of standard GEM 1000 mg/m2/30 min wkly ×7 over 56 days then wkly ×3 q28 d (ARM A) vs. FDR GEM 1500 mg/m2/150 min wkly ×3 q28 days (ARM B) or GEM 1000 mg/m2/100-min/d1 + oxaliplatin 100 mg/m2/d2 q14d (ARM C). Secondary endpoints are the comparison of the experimental regimens, toxicity, response, patterns of failure, progression-free survival and quality-of-life. Methods: This multi-institutional trial included patients (pts) with measurable and non-measurable advanced, unresectable PAN CA, normal organ function and PS 0–2. Pts were chemonaive, although prior adjuvant radiosensitizing 5FU was permitted. Pts were stratified by PS 0–1 vs 2 and locally advanced vs metastatic disease The study was designed to detect a 33% difference in median survival (hazard ratio 1.33) with 81% power while maintaining a significance level of 2.5% in a two-sided test for each of the two primary comparisons, assuming exponential failure and median survival of 6 mo for Arm A and 8 mo for Arm B and C (N = 750 eligible). Results: Accrual started in 3/03 and completed in 3/05. Median follow up is 5.8 mo. 833 pts (53% men; 88% PS 0–1; 88% metastatic), were randomized with 280, 277 and 276 pts in Arms A, B and C. The third interim analysis was conducted with 89.5% information on 3/2006. The predominant toxicity, available for 758 pts, was grade 3/4 myelosuppression and fatigue. Two deaths from ARDS and infection occurred. Median OS for ARMS A, B, and C are 4.96, 6.01 and 6.47 months, respectively. Hazard ratio A vs B is 1.21 with stratified log rank of 0.053 and for A vs C is 1.22 with stratified log rank of 0.045, neither statistically significant. Conclusion: E6201 final OS results will be available in June, 2006. [Table: see text] [Table: see text]
Randomized phase III trial of standard D2 versus D2 + para-aortic lymph node (PAN) dissection (D) for clinically M0 advanced gastric cancer: JCOG9501
Authors: Sasako M. , Sano T. , Yamamoto S. , Nashimoto A. , Kurita A. , Furukawa H. , Tsujinaka T. , Kinoshita T. , Arai K. 
Published: March 2020

LBA4015 Background: The INT-0116 study proved the efficacy of radiochemotherapy after R0 resection for gastric cancer and thus the importance of the local control and the insufficiency of D0/1 surgery. Recently D2 surgery was for the first time proven to improve the survival compared with D1 in a Taiwanese RCT (Lancet Oncol 2006). In our study, D2+PAND was compared with D2 in a RCT. Low operative mortality has been reported (Sano et al. J Clin Oncol 2004) and we now present the survival results. Methods: Eligibility criteria included; histologically proven adenocarcinoma, cT2b-T4, cM0, no macroscopic metastasis to the PAN, negative lavage cytology, adequate organ function, and age <76. Linitis plastica was excluded. Eligible pts were randomly assigned to D2 with or without PAND during surgery. All patients were followed without adjuvant therapy until recurrence. The primary endpoint was overall survival (OS) to be compared by stratified log-rank test. Assuming 256 eligible pts in each arm, the study had 75% power to detect 0.73 hazard ratio for D2+PAND to D2 in OS at 0.05 one-sided alpha. Results: Between 07/1995 and 04/2001, 523 pts were randomized (263 to D2 and 260 to D2+PAND). Baseline characteristics were well balanced between the arms. At the time of the final analysis on 23/03/06, 191 (96 and 95, in D2 and D2+PAND, respectively) had died. The 3- and 5-year OS were 76% and 69% in D2 and 76% and 70% in D2+PAND, respectively (p = 0.57, Hazard ratio was 1.03 (95% CI: 0.77–1.37)). Disease free survival did not show any difference between the groups as well. Median operation time was 63 minutes longer and median blood loss was 230 ml larger in D2+PAND than in D2. There was no difference in the incidence of major surgical complications and hospital mortality (0.8% in both arms). Conclusions: D2 or D2+PAND could be carried out safely and showed excellent survival for advanced gastric cancer treated with curative intent. PAND could not improve the survival achieved by D2. General use of PAND should be avoided. No significant financial relationships to disclose.
First mature analysis of the Intergroup Exemestane Study
Authors: Coombes R. C. , Paridaens R. , Jassem J. , Van de Velde C. J. , Delozier T. , Jones S. E. , Hall E. , Kilburn L. S. , Snowdon C. F. , Bliss J. M. 
Published: March 2020

LBA527 Background: We have previously shown that switching to exemestane (E) after 2–3 years tamoxifen (T) improves disease free survival (DFS) in postmenopausal (PM) women with early breast cancer (BC). We report results with 95% of patients (pts) having ≥3 years follow-up. Methods: 4724 PM pts (2352 E vs 2372 T) with ER +ve/unknown unilateral BC, disease-free after 2–3 years T, were randomized to continue T or switch to E to complete a total of 5 years adjuvant endocrine therapy. 122 pts (56 E vs 66 T) originally reported as ER unknown were later found to be ER −ve. In addition to intention to treat (ITT), we repeated analyses excluding ER −ve pts. Adverse events (pre relapse) by treatment received were analysed on treatment (TRT) and also including follow-up (TRTFU). In safety analyses P < 0.01 was taken as significant due to multiple testing. Results: With median follow up of 58 months there were 808 first events (disease relapse, contralateral breast cancer (CLBC), intercurrent death) and 483 deaths. See table for unadjusted hazard ratios (HR). In ER +ve/unknown pts, adjusting for pre-specified prognostic factors of nodal status, chemo use, HRT use, gave HR for DFS of 0.74 (0.64, 0.85); p < 0.0001 and for overall survival (OS) of 0.83 (0.69, 0.99); P = 0.04. There were 145 intercurrent deaths (65 E vs 80 T), including deaths from cardiac (14 E vs 13 T), vascular (17 E vs 11 T) and other cancers (20 E vs 35 T). No statistically significant differences in myocardial infarctions, angina, or cerebrovascular accidents were observed. In T pts there were more thromboembolic (TRT p = 0.006, TRTFU p = NS) and serious gynaecologic events (TRT p < 0.001, TRTFU p < 0.001) and less fractures (TRT p = NS, TRTFU p = 0.003). Conclusions: Switching to E following 2–3 years of T significantly improves DFS, reducing chance of first event, CLBC and distant recurrence. In ER +ve/unknown pts, the switching strategy with E significantly reduces the risk of dying. [Table: see text] [Table: see text]
GLP-2, EGF, and the Intestinal Epithelial IGF-1 Receptor Interactions in the Regulation of Crypt Cell Proliferation
Authors: Fesler Zivit , Mitova Emilia , Brubaker Patricia L 
Published: March 2020

Abstract
Glucagon-like peptide-2 (GLP-2) is an intestinotrophic hormone that promotes intestinal growth and proliferation through downstream mediators, including epidermal growth factor (EGF) and insulin-like growth factor-1 (IGF-1). EGF synergistically enhances the proliferative actions of IGF-1 in intestinal cell lines, and both of these factors are known to be essential for the trophic effects of GLP-2 in vivo. However, whether EGF and IGF-1 interact to mediate the proliferative actions of GLP-2 in vivo remains unknown. Normal and knockout (KO) mice lacking the intestinal epithelial IGF-1 receptor (IE-IGF-1R) were therefore treated chronically with EGF and/or long-acting human hGly2GLP-2, followed by determination of intestinal growth parameters. Intestines from control and IE-IGF-1R KO mice were also used to generate organoids (which lack the GLP-2 receptor) and were treated with EGF and/or IGF-1. Combination treatment with EGF and hGly2GLP-2 increased small intestinal weight and crypt-villus height in C57Bl/6 mice in an additive manner, whereas only hGly2GLP-2 treatment increased crypt cell proliferation. However, although combination treatment also increased small intestinal weight and crypt-villus height in IE-IGF-1R KO mice, the proliferative responses to hGly2GLP-2 alone or with EGF were diminished in these animals. Finally, IGF-1 treatment of organoids undergoing EGF withdrawal was not additive to the effect of EGF replacement on proliferation, but could restore normal proliferation in the absence of EGF. Together, these findings demonstrate that the intestinal proliferative effects of hGly2GLP-2 are augmented by exogenous EGF in a manner that is partially dependent upon IE-IGF-1R signaling.
Assessment Scores of a Mock Objective Structured Clinical Examination Administered to 99 Anesthesiology Residents at 8 Institutions
Authors: Tanaka Pedro , Park Yoon Soo , Liu Linda , Varner Chelsia , Kumar Amanda H. , Sandhu Charandip , Yumul Roya , McCartney Kate Tobin , Spilka Jared , Macario Alex 
Published: March 2020

BACKGROUND:
Objective Structured Clinical Examinations (OSCEs) are used in a variety of high-stakes examinations. The primary goal of this study was to examine factors influencing the variability of assessment scores for mock OSCEs administered to senior anesthesiology residents.

METHODS:
Using the American Board of Anesthesiology (ABA) OSCE Content Outline as a blueprint, scenarios were developed for 4 of the ABA skill types: (1) informed consent, (2) treatment options, (3) interpretation of echocardiograms, and (4) application of ultrasonography. Eight residency programs administered these 4 OSCEs to CA3 residents during a 1-day formative session. A global score and checklist items were used for scoring by faculty raters. We used a statistical framework called generalizability theory, or G-theory, to estimate the sources of variation (or facets), and to estimate the reliability (ie, reproducibility) of the OSCE performance scores. Reliability provides a metric on the consistency or reproducibility of learner performance as measured through the assessment.

RESULTS:
Of the 115 total eligible senior residents, 99 participated in the OSCE because the other residents were unavailable. Overall, residents correctly performed 84% (standard deviation [SD] 16%, range 38%–100%) of the 36 total checklist items for the 4 OSCEs. On global scoring, the pass rate for the informed consent station was 71%, for treatment options was 97%, for interpretation of echocardiograms was 66%, and for application of ultrasound was 72%. The estimate of reliability expressing the reproducibility of examinee rankings equaled 0.56 (95% confidence interval [CI], 0.49–0.63), which is reasonable for normative assessments that aim to compare a resident’s performance relative to other residents because over half of the observed variation in total scores is due to variation in examinee ability. Phi coefficient reliability of 0.42 (95% CI, 0.35–0.50) indicates that criterion-based judgments (eg, pass-fail status) cannot be made. Phi expresses the absolute consistency of a score and reflects how closely the assessment is likely to reproduce an examinee’s final score. Overall, the greatest (14.6%) variance was due to the person by item by station interaction (3-way interaction) indicating that specific residents did well on some items but poorly on other items. The variance (11.2%) due to residency programs across case items was high suggesting moderate variability in performance from residents during the OSCEs among residency programs.

CONCLUSIONS:
Since many residency programs aim to develop their own mock OSCEs, this study provides evidence that it is possible for programs to create a meaningful mock OSCE experience that is statistically reliable for separating resident performance.
Relación entre el ángulo de la base craneal y las clases esqueletales en una población adulta de Paraguay
Authors: Amarilla Cristell , Maldonado Renault Clara , Galeano Leticia , Pratt Giosa Julio , Díaz-Reissner Clarisse 
Published: March 2020

Introducción: numerosos estudios mencionan que las variaciones del crecimiento y orientación del ángulo de la base craneal pueden alterar la posición de ambos maxilares en relación con la base craneal. En este estudio, se busca relacionar el ángulo de la base craneal con las clases esqueletales, en telerradiografías laterales de pacientes adultos que acudieron a la Clínica Odontológica del Instituto Latinoamericano de Estudios Superiores, de la ciudad de Asunción, Paraguay, entre los años 2010 y 2018. Materiales y métodos: estudio transversal retrospectivo. Para clasificar la clase esqueletal, se utilizó el ángulo ANB de Steiner, y para determinar el ángulo de la base craneal posterior, el NSBa de Varjanne y Koski. Luego, se aplicó la prueba chi-cuadrado para relacionar el ángulo de la base craneal y las clases esqueletales, con un nivel de confianza del 95 %. Resultados: formaron parte del estudio 185 telerradiografías laterales de cráneo de pacientes que acudieron a la clínica. La media del ángulo NSBa fue 128.4 ° ± 5.17 °; la clase I fue de 128.27 ° ± 5.27 °; la clase II, de 129.1 ° ± 4.7 °; y la clase III, de 127.84 ° ± 5 °. El 65.95 % posee valores del ángulo NSBa fuera de la norma, de los cuales el 87.7 % presentan un ángulo cerrado. Conclusión: el promedio del ángulo de la base craneal estaba fuera de la norma en todas las clases esqueletales, siendo más frecuente la flexión craneal, en orden decreciente para las clases III, I y II.
Seasonal Effects of Strength Endurance vs. Power Training in Young Female Soccer Athletes
Authors: Lesinski Melanie , Prieske Olaf , Chaabene Helmi , Granacher Urs 
Published: March 2020

Abstract
Lesinski, M, Prieske, O, Chaabene, H, and Granacher, U. Seasonal effects of strength endurance vs. power training in young female soccer athletes. J Strength Cond Res 35(12S): S90–S96, 2021—This study examined the seasonal effects of strength endurance training (SET) vs. power training (PT) on physical fitness and body composition in young female soccer players. Thirty-six young female elite soccer players (15 ± 1 years; maturity offset +3 ± 1 years) were allocated to progressive SET (n = 19) or PT (n = 17). Over the course of one soccer season, SET performed slow movement velocity, moderate intensity (50–60% of the 1 repetition maximum [1RM]; 20–40 repetitions) strength exercises while PT performed moderate-to-high intensity (50–95% of the 1RM; 3–8 repetitions), high movement velocity strength exercises (2 sessions·wk−1). Before and after training, tests were performed for the assessment of muscle strength (1RM leg press), jump performance (countermovement jump [CMJ], drop jump [DJ]), muscular endurance (ventral Bourban test), linear speed (10 m, 20 m), change-of-direction (CoD) speed (T-test), dynamic balance (Y-balance test), sport-specific performance (kicking velocity), and body composition (lean body mass and fat mass). An analysis of covariance was used to test for between-group differences at post-test with baseline values as covariate. No significant between-group differences were observed in terms of total training volume over the respective soccer seasons (p = 0.069; d = 0.68). At post-test, SET showed significantly better ventral Bourban and T-test performances (d = 1.28–2.28; p = 0.000–0.001) compared with PT. However, PT resulted in significantly better 1RM leg press, DJ, 10-m, and 20-m sprint performances (d = 0.85–1.44; p = 0.000–0.026). No significant between-group differences were observed at post-test for CMJ, Y-balance test, kicking performance, and body composition (d = 0.20–0.74, p = 0.051–0.594). Our findings are mainly in accordance with the principle of training specificity. Both SET and PT are recommended to be implemented in young female elite soccer players according to the respective training period.
Jump and Change of Direction Speed Asymmetry Using Smartphone Apps: Between-Session Consistency and Associations With Physical Performance
Authors: Bishop Chris , Perez-Higueras Rubio Mario , Gullon Igor Lopez , Maloney Sean , Balsalobre-Fernandez Carlos 
Published: March 2020

Abstract
Bishop, C, Perez-Higueras Rubio, M, Gullon, IL, Maloney, S, and Balsalobre-Fernandez, C. Jump and change of direction speed asymmetry using smartphone apps: between-session consistency and associations with physical performance. J Strength Cond Res 36(4): 927–934, 2022—The aims of this study were to (a) quantify the magnitude and direction of asymmetry from jump and change of direction speed (CODS) tests and (b) determine the relationship between these asymmetries and jump and CODS performance, in a test-retest design. Thirty Spanish national-level youth basketball athletes performed single leg countermovement jumps (SLCMJs), single leg drop jumps (SLDJs), and 505 CODS tests, all assessed using the My Jump 2 and CODTimer smartphone applications. All tests showed good to excellent reliability, with no significant differences identified between test sessions in jump, CODS, or asymmetry data. The direction of asymmetry showed substantial levels of agreement between test sessions for jump height during the SLDJ (Kappa = 0.72), but only fair levels of agreement for reactive strength during the SLDJ (Kappa = 0.25), fair levels of agreement for jump height during the SLCMJ (Kappa = 0.29), and slight levels of agreement for total time during the 505 test (Kappa = 0.18). Jump height asymmetry from the SLDJ was significantly associated with reduced jump height (ρ = −0.44), reactive strength (ρ = −0.46) and 505 times (ρ = 0.45–0.48) in test session 1, and reactive strength (ρ = −0.42) and 505 times (ρ = 0.40) in test session 2. These data show that jump height asymmetry from the SLDJ was associated with reduced jump and CODS performance in youth basketball athletes during repeated test sessions. In addition, the same asymmetry metric was the only one to show substantial levels of agreement between test sessions. Owing to the consistency of these data, SLDJ height asymmetry may be a useful metric to measure when monitoring interlimb asymmetries.
Shared Physiological Correlates of Multisensory and Expectation-Based Facilitation
Authors: Kayser Stephanie J. , Kayser Christoph 
Published: March 2020

AbstractPerceptual performance in a visual task can be enhanced by simultaneous multisensory information, but can also be enhanced by a symbolic or amodal cue inducing a specific expectation. That similar benefits can arise from multisensory information and within-modality expectation raises the question of whether the underlying neurophysiological processes are the same or distinct. We investigated this by comparing the influence of the following three types of auxiliary probabilistic cues on visual motion discrimination in humans: (1) acoustic motion, (2) a premotion visual symbolic cue, and (3) a postmotion symbolic cue. Using multivariate analysis of the EEG data, we show that both the multisensory and preceding visual symbolic cue enhance the encoding of visual motion direction as reflected by cerebral activity arising from occipital regions ∼200–400 ms post-stimulus onset. This suggests a common or overlapping physiological correlate of cross-modal and intramodal auxiliary information, pointing to a neural mechanism susceptive to both multisensory and more abstract probabilistic cues. We also asked how prestimulus activity shapes the cue–stimulus combination and found a differential influence on the cross-modal and intramodal combination: while alpha power modulated the relative weight of visual motion and the acoustic cue, it did not modulate the behavioral influence of a visual symbolic cue, pointing to differences in how prestimulus activity shapes the combination of multisensory and abstract cues with task-relevant information.
Tafsîr Khuluqun ‘Adzîm: A Methodological Studies
Authors: Jannah Saadatul 
Published: March 2020

Since 16th century until the recent age, study commentary is increasing gradually in Indonesia. It was characterized by the spirit of produce commentaries from scholars of Indonesia (pre-modern) such as works of Abd al-Raûf al-Sinkilî (Tarjumân al-Mustafid), Syaikh Nawawî (Tafsir Maraẖ Labid) and Aẖmad Sanusî (Tafsir al-Qurân al-Karîm), and modern era explicitly Quraish Shihab (Tafsir al-Misbah) and Didin Hafidhudddin (Tafsir al-Hijri). On the other hand, Quranic exegesis is magnetizing the modern society, academia, and the government. Two things are a sign that Indonesia necessitates developing new outlooks contained in the works of interpretation, so the view of Indonesian society are to be more extensive and varied without being limited by one of his Indonesian commentators. Yunan Yusûf , one of the Indonesian Muslim philosopher, within Tafsir Khuluqun 'Adzîm endeavors coloring Indonesian elucidation by creating distinctive work that is an interpretation of the Quran from the short chapters (Madanî) to the extended chapters (Makî). This article discovers specifically the explanation of the al-Mulk to find a methodology, sources, references and pattern of his works. This paper depicts qualitative method with the analytical comparative approach through the two references commentaries Indonesia Tafsîr al-Azhâr and al-Miṣbah. Yunan interprets the Quran critically and decisively utilizing the color philosophy. He is able to convey the message of the Qur'an by using the correlation of the Quran (munâsabah al-Qurân bi al-Qurân) either on his work title or his clarification content. This article concludes that the better sources is preferred the more authentic the exegesis is and the more dominant the type of commentaries is the more pattern work is.
Queda entre idosos: preditores e distribuição espacial
Authors: Araújo Ingrid Vitória de Sousa , Gomes Nayara Cândida , Nascimento Janaína Santos , Ribeiro Camila Cristina Neves Romanato , Tavares Darlene Mara dos Santos 
Published: March 2020

Objetivos Calcular a prevalência de quedas, nos últimos 12 meses, entre idosos da comunidade; verificar a ocorrência de quedas em idosos da comunidade, segundo características sociodemográficas e de saúde e identificar clusters de quedas, entre idosos no município de Uberaba.Métodos Estudo transversal conduzido com 612 idosos residentes na zona urbana de Uberaba. Procederam-se às análises descritiva e bivariada com o teste qui-quadradom (p<0,05). Para estimar a intensidade dos eventos utilizou-se o Kernel estimation. Projeto aprovado pelo Comitê de Ética em Pesquisa, parecer Nº 573.833.Resultados Constatou-se que 24,7% dos idosos tiveram quedas nos últimos 12 meses. A maior proporção dos idosos que sofreu quedas era do sexo feminino (p=0,004); com 80 anos ou mais (p=0,001); sem escolaridade (p=0,026); morava só (p=0,049); sem companheiro (p=0,002); com autopercepção de saúde negativa (p<0,001); dependente para as ABVD (p=0,049) e AIVD (p=0,027); com menor participação nas AAVD (p=0,003); pré-frágeis/frágeis p<0,001) e com desempenho físico baixo/ruim(p<0,001). Os maiores aglomerados de ocorrência de quedas foram na região centro-oeste do município, seguido pela região sudeste.Conclusão Conhecer o perfil e os fatores associados à ocorrência de quedas entre idosos possibilita que os profissionais de saúde desenvolvam ações direcionadas a prevenção, ao monitoramento e controle desses fatores.