bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inductive general game playing
Authors: Cropper Andrew , Evans Richard , Law Mark 
Published: November 2019

AbstractGeneral game playing (GGP) is a framework for evaluating an agent’s general intelligence across a wide range of tasks. In the GGP competition, an agent is given the rules of a game (described as a logic program) that it has never seen before. The task is for the agent to play the game, thus generating game traces. The winner of the GGP competition is the agent that gets the best total score over all the games. In this paper, we invert this task: a learner is given game traces and the task is to learn the rules that could produce the traces. This problem is central toinductive general game playing(IGGP). We introduce a technique that automatically generates IGGP tasks from GGP games. We introduce an IGGP dataset which contains traces from 50 diverse games, such asSudoku,Sokoban, andCheckers. We claim that IGGP is difficult for existing inductive logic programming (ILP) approaches. To support this claim, we evaluate existing ILP systems on our dataset. Our empirical results show that most of the games cannot be correctly learned by existing systems. The best performing system solves only 40% of the tasks perfectly. Our results suggest that IGGP poses many challenges to existing approaches. Furthermore, because we can automatically generate IGGP tasks from GGP games, our dataset will continue to grow with the GGP competition, as new games are added every year. We therefore think that the IGGP problem and dataset will be valuable for motivating and evaluating future research.
Analysis of transporter associated with antigen presentation (TAP) genes polymorphisms with HIV-1 infection
Authors: Abitew Abaineh Munshea , Sobti Ranbir Chander , Sharma Vijay Lakshmi , Wanchu Ajay 
Published: November 2019

AbstractHuman leukocyte antigen (HLA) class I molecules of the human major histocompatibility complex (MHC) play an important role in modulating immune response. HLA class I molecules present antigenic peptides to CD8+T cells and thereby play a role in the immune surveillance of cells infected with viruses.TAP1andTAP2areMHC-II-encoded genes necessary for the generation of a cellular immune response and polymorphism of these genes can influence the specificity of peptides preferentially presented by the MHC class I molecules and the outcome of the immune response. Several studies implicated genetic variation inTAPgenes to various immune-mediated and infectious diseases. To determine the correlation between HIV-1 infection and theTAP1andTAP2genes polymorphisms, we performed PCR–RFLP assay of these genes in 500 HIV-1 seropositives and the matched seronegative individuals. Statistical analysis of the data disclosed no correlation betweenTAP1(C/T intron 7) gene polymorphism and HIV-1/AIDS disease. However, the current results demonstrated that the heterozygousA/G[OR (95% CI) 1.39 (1.06–1.83),P = 0.0171] and homozygousG/G[OR (95% CI) 3.38(1.56–7.46),P = 0.0010] variants ofTAP2(A/G exon 11) (T665A) gene are positively associated with an increased risk of HIV-1/AIDS infection. This case–control analysis might suggest a possible role ofTAP2(A/G exon 11) (T665A) gene in the susceptibility to HIV-1 infection and disease outcome among North Indian patients.
New uracil analogs as downregulators of ABC transporters in 5-fluorouracil-resistant human leukemia HL-60 cell line
Authors: Długosz-Pokorska Angelika , Pięta Marlena , Janecki Tomasz , Janecka Anna 
Published: November 2019

AbstractOverexpression of ATP-binding cassette (ABC) transporters causing multidrug resistance (MDR) in cancer cells is one of the major obstacles in cancer chemotherapy. The 5-FU resistant subclone (HL-60/5FU) of the human HL-60 promyelocytic leukemia cell line was selected by the conventional method of continuous exposure of the cells to the drug up to 0.08 mmol/L concentration. HL-60/5FU cells exhibited six-fold enhanced resistance to 5-FU than HL-60 cells. RT-PCR and ELISA assay showed significant overexpression of MDR-related ABC transporters, ABCB1, ABCG2 but especially ABCC1 in the HL-60/5FU as compared with the parental cell line. Three novel synthetic 5-methylidenedihydrouracil analogs, U-236, U-332 and U-359, selected as highly cytotoxic for HL-60 cells in MTT test, showed similar cytotoxicity in the resistant cell line. When co-incubated with 5-FU, these analogs were found to down-regulate the expression of all three transporters. However, the most pronounced effect was caused by U-332 which almost completely abolished ABCC1 expression in the resistant HL-60/5FU cells. Additionally, U-332 inhibited the activity of ATPase, an enzyme which catalyzes hydrolysis of ATP, providing energy to efflux drugs from the cells through the cellular membranes. Taken together, the obtained data suggest that acquired 5-FU resistance in HL-60/5FU cells results from overexpression of ABCC1 and that targeting ABCC1 expression could be a potential approach to re-sensitize resistant leukemia cells to 5-FU. The synthetic uracil analog U-332, which can potently down-regulate ABC transporter expression and therefore disturb drug efflux, can be considered an efficient ABCC1 regulator in cancer cells.
Principal vectors and equivalent mass descriptions for the equations of motion of planar four-bar mechanisms
Authors: Meijaard J. P. , van der Wijk V. 
Published: November 2019

AbstractThe use of principal points and principal vectors in the formulation of the equations of motion of a general 4R planar four-bar linkage is shown with two kinds of methods, one that opens kinematic loops and one that does not. The opened kinematic loop approach analyses the moving links as a system with a tree connectivity, introducing reaction forces for closing the loops. Compared with the conventional Newton–Euler method, this approach results in fewer equations and constraint forces, whereas the mass matrix entries remain meaningful, but there is a stronger coupling between the equations. Two equivalent mass formulations for the closed kinematic loop approach are presented, which need not open the loop and introduce loop constraint forces in the equations of motion. With the method of complex joint masses, the mass of the links closing the loops is represented by real and virtual equivalent masses, defining the principal points. The principle of virtual work with the inclusion of inertia terms is used to derive the equations of motion. As an example the dynamic balance conditions of the four-bar linkage are derived. With the method of the equivalent mass matrix it is shown how a constant mass matrix can be used to describe the dynamics of binary links with an arbitrary mass distribution. A four-bar linkage could be modelled with only three truss elements instead of the conventional result with three or more beam elements, which gives a significant reduction of the computational complexity.
Dyadic Norm Besov-Type Spaces as Trace Spaces on Regular Trees
Authors: Koskela Pekka , Wang Zhuang 
Published: November 2019

AbstractIn this paper, we study function spaces defined via dyadic energies on the boundaries of regular trees. We show that correct choices of dyadic energies result in Besov-type spaces that are trace spaces of (weighted) first order Sobolev spaces.
Investigation of Hydrodynamic Dispersion and Intra-pore Turbulence Effects in Porous Media
Authors: Jouybari Nima Fallah , Lundström T. Staffan , Hellström J. Gunnar I. 
Published: November 2019

AbstractThe aim of the present paper is to evaluate and compare the pore level hydrodynamic dispersion and effects of turbulence during flow in porous media. In order to compute these quantities, large eddy simulations of turbulent flow in five unit cells comprised of spherical particles are performed and the results are averaged over the cells. Visualizations of vortical structures reveal that the size of the turbulence structures is of the size of the pores. Investigations furthermore yield that volume-averaged values of the hydrodynamic dispersion are of the same order as the Reynolds stress within the pores. It is also shown that the effect of intra-pore turbulence and hydrodynamic dispersion on the redistribution of macroscopic momentum within the porous medium is negligible compared to Forchheimer term. A discussion is provided on the accuracy of the eddy viscosity hypothesis in the modeling of the volume-averaged intra-pore Reynolds stresses. Finally, the effect of variation in the pore-scale geometry on the turbulence structures and averaged values of hydrodynamic dispersion and Reynolds stress is investigated.
Data Mining Methods for Prediction of Multi-Component Al-Si Alloy Properties Based on Cooling Curves
Authors: Regulski Krzysztof , Wilk-Kołodziejczyk Dorota , Szymczak Tomasz , Gumienny Grzegorz , Pirowski Zenon , Jaśkowiec Krzysztof , Kluska-Nawarecka Stanisława 
Published: November 2019

AbstractThe paper concerns the mechanical properties of hypoeutectic Al-Si alloy (silumin) with the addition of Cr, Mo, V and W. Changes in microstructure under the impact of these elements result in a change in the mechanical properties. Crystallization of Al-Si alloys determines grain size reduction, which causes a significant increase in their strength properties. Crystallization subjected to modifications through the influence of alloying additives can be described by the cooling curve run. Statistical relationships between the characteristic values of cooling curves and mechanical properties are investigated with data mining techniques of regression, especially regression trees. Such knowledge could provide an ability of a property prediction on the basis of cooling curves in terms of the benefits of a short time of the curve registration.
Non-spherical particle mixing behaviors by spherical inert particles assisted in a fluidized bed
Authors: Ren An-Xing , Wang Tian-Yu , Tang Tian-Qi , He Yu-Rong 
Published: November 2019

AbstractFluidized beds are widely used in many industrial fields such as petroleum, chemical and energy. In actual industrial processes, spherical inert particles are typically added to the fluidized bed to promote fluidization of non-spherical particles. Understanding mixing behaviors of binary mixtures in a fluidized bed has specific significance for the design and optimization of related industrial processes. In this study, the computational fluid dynamic–discrete element method with the consideration of rolling friction was applied to evaluate the mixing behaviors of binary mixtures comprising spherocylindrical particles and spherical particles in a fluidized bed. The simulation results indicate that the differences between rotational particle velocities were higher than those of translational particle velocities for spherical and non-spherical particles when well mixed. Moreover, as the volume fraction of the spherocylindrical particles increases, translational and rotational granular temperatures gradually increase. In addition, the addition of the spherical particles makes the spherocylindrical particles preferably distributed in a vertical orientation.
Structures, functions, and mechanisms of filament forming enzymes: a renaissance of enzyme filamentation
Authors: Park Chad K. , Horton Nancy C. 
Published: November 2019

AbstractFilament formation by non-cytoskeletal enzymes has been known for decades, yet only relatively recently has its wide-spread role in enzyme regulation and biology come to be appreciated. This comprehensive review summarizes what is known for each enzyme confirmed to form filamentous structuresin vitro, and for the many that are known only to form large self-assemblies within cells. For some enzymes, studies describing both thein vitrofilamentous structures and cellular self-assembly formation are also known and described. Special attention is paid to the detailed structures of each type of enzyme filament, as well as the roles the structures play in enzyme regulation and in biology. Where it is known or hypothesized, the advantages conferred by enzyme filamentation are reviewed. Finally, the similarities, differences, and comparison to the SgrAI endonuclease system are also highlighted.
Usnic Acid Derivatives as Cytotoxic Agents Against Cancer Cells and the Mechanisms of Their Activity
Authors: Guzow-Krzemińska Beata , Guzow Katarzyna , Herman-Antosiewicz Anna 
Published: November 2019

Abstract
Purpose of Review
This article summarises recent research on modifications of the structure or formula of usnic acid (UA), a lichen secondary metabolite, in order to obtain derivatives with higher bioavailability, potency and selectivity against cancer cells and presents the current knowledge on the mechanisms of action of such compounds.

Recent Findings
Numerous approaches have been undertaken to improve bioactivity of UA concerning its use as an anticancer drug. Among them, the synthesis of UA salts or complexation with 2-hydroxypropyl-β-cyclodextrin to improve its solubility and the encapsulation using different carriers (including various nanomaterials) to stabilise UA in biological fluids and improve their penetrance to, and release in, cancer cells were applied.. Synthetic modification of the UA structure has been explored to obtain more active and cancer-specific derivatives. Recent work indicates that some modifications of the C or A ring of UA selectively increase its antiproliferative potential against cancer cells. Moreover, specific changes in the UA structure allow to obtain derivatives which inhibit enzymes important for the cancer cells’ survival, such as mTOR, Pim, TDP1 or PARP. Some of them have been shown to enhance anticancer activity of the already approved chemotherapeutics, such as topotecan. Others, when used in an animal cancer xenograft model, were superior to UA in retardation of tumour growth and less toxic that the parent compound.

Summary
UA is a promising lead compound for synthesis of anticancer drugs. Further work on its modifications, mechanisms of activity and validation in animal models is critical for development of effective therapeutics.
A cold change: how short low temperature exposure affects primary metabolism in leaves and stems of two eucalyptus species
Authors: Domingues-Junior Adilson Pereira , Daloso Danilo de Menezes , Machado Mariana , Rosado-Souza Laíse , de Souza Leonardo Perez , Fernie Alisdair Robert , Mazzafera Paulo 
Published: November 2019

AbstractPlants often modify their metabolism in order to regain homeostasis and maintain survival in the face of stressful conditions. Here, two species of eucalyptus, E. globulus and E. grandis (adapted and non-adapted to low temperature, respectively), were exposed to either 10 °C or 25 °C over 24 h, and changes in gene expression and metabolite levels were analyzed. The aim of this experiment was to investigate the dynamic of short period changes in the energy metabolism of source (leaves) and sink (stem) tissues in these contrasting species regarding low temperature. We expected to observe a distinct pattern on carbon metabolism and source-to-sink relationship between both species which would be related to their different vegetative responses when facing low temperatures. In that way, E. globulus plants showed a differential expression in leaves and stems of SnRK1 genes system (responsible for energy availability control in plants), that was strongly associated to the changes in carbon metabolism and the main difference between the response when both species face cold. Taken together, the results suggest that low temperatures (10 °C) are able to increase the sink strength of stem tissues and the carbon assimilation in leaves of E. globulus, supporting a higher vegetative growth rate. In E. grandis, on the other hand, exposure to 10 °C promoted a higher consumption of carbon skeletons without better growth rate as a counterpart, suggesting that under cold conditions, these two eucalyptus species differ in the way they coordinate the interaction between the activation of SnRK1 system and primary metabolism in source and sink tissues.
Urban growth modeling using cellular automata model and AHP (case study: Qazvin city)
Authors: Falah Nahid , Karimi Alireza , Harandi Ali Tavakoli 
Published: November 2019

AbstractIrregular growth in the surrounding lands is one of the most important issues for the city managers and programmers at various levels. Whereas nowadays study the process of land use changes to urban use plays the main role in long time decisions and programs, predicting the process of city growth and its modeling in future with precise methods for management and urban expansion control will be necessary more than other times. One of urban growth modeling is cellular automata model. This model has been used widely in urban studies because of its dynamic nature, ability of Integration with other models, ability to modify the model and required data availability. In this article, to maximize the efficiency of the cellular automata model and its constraints, the integration of the AHP automated cell model and cellular automata model have been used; and its accuracy has been evaluated. This article has been practical because its related principles has been collected in a documentary manner and has been used to analyses the issue in comparative and quantitative methods. Initially, the unplanned growth of Qazvin city has been investigated by Holdern and Shannon model. Then main parameters including distance from roads, land prices, distance from faults, distance from the rivers, soil gender, slope, permission to build land, topography, landscape, view to gardens and forest park as parameters involved in the development of Qazvin city are considered. The input data used in this research are Landsat tm and DEM images of the city of Qazvin in 1996 and 2016. Also, to evaluate the correctness of the model responses, the map of the developed regions in 2016 and the Kappa coefficient have been used. The Kappa coefficient is 92.3%, which is considered significant and appropriate and gave the fact that the Kappa number is acceptable. The Qazvin simulation was made in 2026. The results show that the proposed integrated model is suitable for studying urban growth.
Cell Membrane Coating Technology: A Promising Strategy for Biomedical Applications
Authors: Liu Yao , Luo Jingshan , Chen Xiaojia , Liu Wei , Chen Tongkai 
Published: November 2019

AbstractCell membrane coating technology is an approach to the biomimetic replication of cell membrane properties, and is an active area of ongoing research readily applicable to nanoscale biomedicine. Nanoparticles (NPs) coated with cell membranes offer an opportunity to unite natural cell membrane properties with those of the artificial inner core material. The coated NPs not only increase their biocompatibility but also achieve effective and extended circulation in vivo, allowing for the execution of targeted functions. Although cell membrane-coated NPs offer clear advantages, much work remains before they can be applied in clinical practice. In this review, we first provide a comprehensive overview of the theory of cell membrane coating technology, followed by a summary of the existing preparation and characterization techniques. Next, we focus on the functions and applications of various cell membrane types. In addition, we collate model drugs used in cell membrane coating technology, and review the patent applications related to this technology from the past 10 years. Finally, we survey future challenges and trends pertaining to this technology in an effort to provide a comprehensive overview of the future development of cell membrane coating technology.
Selecting the best probability distribution for at-site flood frequency analysis; a study of Torne River
Authors: Ul Hassan Mahmood , Hayat Omar , Noreen Zahra 
Published: November 2019

AbstractAt-site flood frequency analysis is a direct method of estimation of flood frequency at a particular site. The appropriate selection of probability distribution and a parameter estimation method are important for at-site flood frequency analysis. Generalized extreme value, three-parameter log-normal, generalized logistic, Pearson type-III and Gumbel distributions have been considered to describe the annual maximum steam flow at five gauging sites of Torne River in Sweden. To estimate the parameters of distributions, maximum likelihood estimation and L-moments methods are used. The performance of these distributions is assessed based on goodness-of-fit tests and accuracy measures. At most sites, the best-fitted distributions are with LM estimation method. Finally, the most suitable distribution at each site is used to predict the maximum flood magnitude for different return periods.
THE CONSISTENCY STRENGTH OF LONG PROJECTIVE DETERMINACY
Authors: AGUILERA JUAN P. , MÜLLER SANDRA 
Published: November 2019

AbstractWe determine the consistency strength of determinacy for projective games of length ω2. Our main theorem is that $\Pi _{n + 1}^1 $-determinacy for games of length ω2 implies the existence of a model of set theory with ω + n Woodin cardinals. In a first step, we show that this hypothesis implies that there is a countable set of reals A such that Mn (A), the canonical inner model for n Woodin cardinals constructed over A, satisfies $$A = R$$ and the Axiom of Determinacy. Then we argue how to obtain a model with ω + n Woodin cardinal from this.We also show how the proof can be adapted to investigate the consistency strength of determinacy for games of length ω2 with payoff in $^R R\Pi _1^1 $ or with σ-projective payoff.
Canal wall down mastoidectomy with obliteration versus canal wall up mastoidectomy in primary cholesteatoma surgery
Authors: Wilkie M D , Chudek D , Webb C J , Panarese A , Banhegyi G 
Published: November 2019

AbstractObjectiveThis study sought to compare disease recidivism rates between canal wall up mastoidectomy and a canal wall down with obliteration technique.MethodsPatients undergoing primary cholesteatoma surgery at our institution over a five-year period (2013–2017) using the aforementioned techniques were eligible for inclusion in the study. Rates of discharge and disease recidivism were analysed using chi-square statistics.ResultsA total of 104 ears (98 patients) were included. The mean follow-up period was 30 months (range, 12–52 months). A canal wall down with mastoid obliteration technique was performed in 55 cases and a canal wall up approach was performed in 49 cases. Disease recidivism rates were 7.3 per cent and 16.3 per cent in the canal wall down with mastoid obliteration and canal wall up groups respectively (p = 0.02), whilst discharge rates were similar (7.3 per cent and 10.2 per cent respectively).ConclusionOur direct comparative data suggest that canal wall down mastoidectomy with obliteration is superior to a canal wall up technique in primary cholesteatoma surgery, providing a lower recidivism rate combined with a low post-operative ear discharge rate.