bluuebunny/crossref_metadata_2025_split huggingface dataset:
UV/Vis Spectroscopy of Copper Formate Clusters: Insight into Metal‐Ligand Photochemistry
Authors: Pascher Tobias F. , Ončák Milan , van der Linde Christian , Beyer Martin K. 
Published: March 2020

AbstractThe electronic structure and photochemistry of copper formate clusters, CuI2(HCO2)3− and CuIIn(HCO2)2n+1−, n≤8, are investigated in the gas phase by using UV/Vis spectroscopy in combination with quantum chemical calculations. A clear difference in the spectra of clusters with CuI and CuII copper ions is observed. For the CuI species, transitions between copper d and s/p orbitals are recorded. For stoichiometric CuII formate clusters, the spectra are dominated by copper d–d transitions and charge‐transfer excitations from formate to the vacant copper d orbital. Calculations reveal the existence of several energetically low‐lying isomers, and the energetic position of the electronic transitions depends strongly on the specific isomer. The oxidation state of the copper centers governs the photochemistry. In CuII(HCO2)3−, fast internal conversion into the electronic ground state is observed, leading to statistical dissociation; for charge‐transfer excitations, specific excited‐state reaction channels are observed in addition, such as formyloxyl radical loss. In CuI2(HCO2)3−, the system relaxes to a local minimum on an excited‐state potential‐energy surface and might undergo fluorescence or reach a conical intersection to the ground state; in both cases, this provides substantial energy for statistical decomposition. Alternatively, a CuII(HCO2)3Cu0− biradical structure is formed in the excited state, which gives rise to the photochemical loss of a neutral copper atom.
Enhanced Stability of Peptide Nanofibers Coated with a Conformal Layer of Polydopamine
Authors: Ji Mingyang , Parquette Jon R. 
Published: March 2020

AbstractThe susceptibility of self‐assembled materials to changes of environmental conditions and mechanical forces often limits their utility for many applications. In this work, the surface of nanofibers formed by β‐sheet peptide self‐assemblies were coated by polydopamine (PDA) deposition. This conformal coating process rendered the nanofiber dimensions and internal π‐stacking chirality impervious to changes in pH, temperature, and physical processing by spin‐coating onto a silicon wafer. Whereas sonication‐induced shearing of the dopamine/naphthalenediimide–dilysine (DA/NDI–KK) composite irreversibly shortened the nanofibers into 100–200 nm segments, the uncoated nanofibers unraveled into single strands upon similar treatment. Additionally, the PDA‐coated nanofibers could be wrapped by an additional layer comprised of a positively charged polyelectrolyte polymer.
Inverse Produktion für nachhaltige Wertstoffkreisläufe – Aktuelle Entwicklungen zur automatisierten Demontage und Entstückung von Elektronikplatinen
Authors: Noll Reinhard , Bergmann Klaus , Fricke‐Begemann Cord , Schreckenberg Frederik 
Published: March 2020

AbstractAm Ende der Lebensdauer elektronischer Produkte gehen immer noch viele der darin enthaltenen Wertstoffe verloren. Mithilfe moderner produktionstechnischer Methoden könnten diese Produkte gezielt zerlegt werden, um hochwertige Sortierfraktionen zu gewinnen. Der Beitrag zeigt Ansätze zu diesen Herausforderungen der inversen Produktion auf. Beispielhaft werden aktuelle Entwicklungen zur automatisierten Demontage und Entstückung von Elektronikplatinen vorgestellt. Moderner Sensor‐ und Lasertechnologie kommt dabei eine Schlüsselrolle für Mess‐ und Entstückungsaufgaben zu. Eine Demontage‐ und Sortierlinie für die stückbezogene Verarbeitung von Mobiltelefonen und Elektronikplatinen mit sieben verketteten Maschinen wurde aufgebaut und in einem Recyclingbetrieb erprobt.
Prevalence of decisional regret among patients who underwent allogeneic hematopoietic stem cell transplantation and associations with quality of life and clinical outcomes
Authors: Cusatis Rachel N. , Tecca Heather R. , D’Souza Anita , Shaw Bronwen E. , Flynn Kathryn E. 
Published: March 2020

BackgroundAllogeneic hematopoietic stem cell transplantation (alloHCT) is potentially curative but with known negative effects on quality of life. In the current study, the authors investigated whether patients expressed regret after undergoing HCT and the relationships between clinical outcomes and quality of life.MethodsCenter for International Blood and Marrow Transplant Research data from 184 adults who completed the Functional Assessment of Cancer Therapy–Bone Marrow Transplant (FACT‐BMT) before undergoing alloHCT and at day 100 were used. Additional time points were 6 months and 12 months. Regret was measured using a FACT‐BMT item not included in scoring: “I regret having the bone marrow transplant.” The authors evaluated FACT‐BMT scores and regret using Studentt‐tests. Covariance pattern models were used to determine predictors of regret over time, including baseline characteristics and post‐alloHCT outcomes (acute or chronic graft‐versus‐host‐disease, disease recurrence).ResultsAt 100 days, 6 months, and 12 months, approximately 6% to 8% of patients expressed regret; a total of 15% expressed regret at any time point. Regret was found to be associated with lower FACT‐BMT scores at 6 months and 12 months (P < .001). Higher baseline FACT‐BMT and social well‐being scores were associated with a reduced risk of expressing regret. The risk of regretting transplantation was 17.5 percentage points (95% confidence interval, 5.5‐29.7 percentage points) greater in patients who developed disease recurrence after HCT compared with patients who did not.ConclusionsAmong patients who underwent alloHCT and lived to 100 days, the majority did not report regretting their transplantation. Regret was found to be related to disease recurrence. Social connectedness may serve as a protective factor against later regret. Future work should explore regret in other patient groups and use qualitative methods to inform best practices for reducing regret.
Genomic landscape of acquired resistance to third‐generation EGFR tyrosine kinase inhibitors in EGFR T790M‐mutant non–small cell lung cancer
Authors: Lee Jiyun , Kim Hong Sook , Lee Boram , Kim Hee Kyung , Sun Jong‐Mu , Ahn Jin Seok , Ahn Myung‐Ju , Park Keunchil , Lee Se‐Hoon 
Published: March 2020

BackgroundEGFR tyrosine kinase inhibitors (TKIs) have shifted the treatment paradigm in advanced EGFR‐mutant non–small cell lung cancer (NSCLC). However, patients who are treated with TKIs inevitably develop acquired resistance by mechanisms that are not fully understood. The purpose of this study was to investigate the mechanism of acquired resistance after treatment with third‐generation EGFR TKIs.MethodsAdvanced EGFR‐mutant NSCLC patients treated with olmutinib or osimertinib who underwent a rebiopsy before treatment or after progression were analyzed retrospectively. Targeted sequencing was performed on 113 specimens (77 pretreatment and 36 posttreatment, including 15 paired samples) obtained via tissue biopsy.ResultsA total of 98 patients were included, 53 (54%) of whom were treated with osimertinib and 45 (46%) of whom were treated with olmutinib. Of the 36 patients with posttreatment biopsies, EGFR‐dependent mechanisms, including C797S and L718Q mutations, were observed in 10 (28%) patients: 29% (5/17) in the osimertinib group and 26% (5/19) in the olmutinib group. EGFR‐independent mechanisms were detected in 21 patients (21/36, 58%): 65% (11/17) in the osimertinib group and 53% (10/19) in the olmutinib group. The disappearance of EGFR T790M was detected in 14 patients (39%); of these patients, 59% (10/17) were treated with osimertinib and 21% (4/19) were treated with olmutinib. Patients who lost the T790M mutation were more inclined to show EGFR‐independent pathways as a secondary resistance mechanism.ConclusionResistance acquired after third‐generation EGFR TKIs is associated with diverse pathways; however, treatment with osimertinib is primarily associated with a loss of EGFR T790M and the subsequent emergence of EGFR‐independent resistance mechanisms.
Retinal topography in two species of flamingo (Phoenicopteriformes: Phoenicopteridae)
Authors: Lisney Thomas J. , Potier Simon , Isard Pierre‐François , Mentek Marielle , Mitkus Mindaugas , Collin Shaun P. 
Published: March 2020

AbstractIn this study, we assessed eye morphology and retinal topography in two flamingo species, the Caribbean flamingo (Phoenicopterus ruber) and the Chilean flamingo (P. chilensis). Eye morphology is similar in both species and cornea size relative to eye size (C:A ratio) is intermediate between those previously reported for diurnal and nocturnal birds. Using stereology and retinal whole mounts, we estimate that the total number of Nissl‐stained neurons in the retinal ganglion cell (RGC) layer in the Caribbean and Chilean flamingo is ~1.70 and 1.38 million, respectively. Both species have a well‐defined visual streak with a peak neuron density of between 13,000 and 16,000 cells mm−2 located in a small central area. Neurons in the high‐density regions are smaller and more homogeneous compared to those in medium‐ and low‐density regions. Peak anatomical spatial resolving power in both species is approximately 10–11 cycles/deg. En‐face images of the fundus in live Caribbean flamingos acquired using spectral domain optical coherence tomography (SD‐OCT) revealed a thin, dark band running nasotemporally just dorsal to the pecten, which aligned with the visual streak in the retinal topography maps. Cross‐sectional images (B‐scans) obtained with SD‐OCT showed that this dark band corresponds with an area of retinal thickening compared to adjacent areas. Neither the retinal whole mounts, nor the SD‐OCT imaging revealed any evidence of a central fovea in either species. Overall, we suggest that eye morphology and retinal topography in flamingos reflects their cathemeral activity pattern and the physical nature of the habitats in which they live.
Controls on microbial and oolitic carbonate sedimentation and stratigraphic cyclicity within a mixed carbonate‐siliciclastic system: Upper Cambrian Wilberns Formation, Llano Uplift, Mason County, Texas, USA
Authors: Lehrmann Daniel J. , Droxler André W. , Harris Paul (Mitch) , Minzoni Marcello , Droxler Dylan A. , Hopson Heath H. , Kelleher Caroline , Khanna Pankaj , Lehrmann Asmara A. , Lhemann Adrien , Mabry Grace , Mercado Lauren , Proctor Jacob M. , Singh Pulkit , Yazbek Lindsey 
Published: March 2020

AbstractThe upper Cambrian Wilberns Formation in central Texas records deposition on a low‐gradient shelf within a mixed carbonate–siliciclastic tidal‐flat system that changes offshore to subtidal shelf and open‐marine oolitic skeletal shoals with large microbial mounds. Siliciclastic sediment is interpreted to have been delivered to the tidal flat by aeolian processes because of the narrow range in grain size and paucity of clay. Tidal influence is dominant as evidenced by reversing currents and desiccation on the tidal flat, and megaripples with reversing current indicators in offshore shoals. Intraclastic conglomerates were deposited in broad channels on the tidal flats during storm surges. Microbialite deposition is interpreted to be controlled by accommodation favouring amalgamated thin biostromes developed in the tidal flat vs. larger mounds with greater synoptic relief in the offshore, and current energy resulting in preferential elongation of offshore mounds in a NE–SW orientation. Intertidal mounds and biostromes grew in the presence of significant siliciclastic flux and trapped it within their structure, whereas offshore large buildups incorporated little siliciclastic component. Oolite and skeletal grainstone formed in tide agitated shoals associated with large subtidal microbial mounds. Storms extensively recycled and redistributed skeletal and oolitic sands from the offshore shoals across the shelf as thin sand sheets. Spatial mixing of siliciclastic and carbonate sediment occurred across the tidal flat and shelf. Low‐frequency and intermediate‐frequency stratigraphic cycles were driven by shifts in the shoreline and changes in rate of siliciclastic flux in response to relative sea‐level fluctuation. Random facies stacking and the lack of metre‐scale cyclicity are interpreted to reflect stratigraphic incompleteness and an episodic signal introduced by storms.
Food addiction and symptoms of depression among inhabitants of the European North of Russia: Associations with sleep characteristics and photoperiod
Authors: Borisenkov Mikhail F. , Popov Sergey V. , Tserne Tatyana A. , Bakutova Larisa A. , Pecherkina Anna A. , Dorogina Olga I. , Martinson Ekaterina A. , Vetosheva Valentina I. , Gubin Denis G. , Solovieva Svetlana V. , Turovinina Elena F. , Symanyuk Elvira E. 
Published: March 2020

AbstractThe purpose of this investigation was to study the sleep‐wake rhythm characteristics of young persons with food addiction (FA) and symptoms of depression. A total of 2,360 young persons living in northern European Russia were included in the study. The average age of the respondents (± standard deviation [SD]) was 17.9 [4.6] years (66.6% female). Each participant provided personal data and filled in three questionnaires: the Munich Chronotype Questionnaire, the Zung Self‐Rating Depression Scale, and the Yale Food Addiction Scale. FA was detected in 8.9% of respondents, and moderate‐to‐severe symptoms of depression were detected in 16.7% of respondents. FA and depressive symptoms were more often detected in females. Age and body mass index were shown to be significantly associated with FA. There were positive associations between the time of sunrise and FA and depressive symptoms. Persons who had symptoms of depression also tended to have a later chronotype, lower sleep efficiency, later sleep onset, higher sleep inertia, and greater sleep latency on school days. A positive relationship between FA and the time of sleep onset on school days was also revealed. Thus, the results indicate that prolonged wakefulness in the evening after sunset was associated with FA.
Damage caused by freeze‐thaw treatment with liquid nitrogen on pore and fracture structures in a water‐bearing coal mass
Authors: Lin Haifei , Li Jinliang , Yan Min , Li Shugang , Qin Lei , Zhang Yizhen 
Published: March 2020

AbstractThe purpose of the study was to explore the microscopic and mesoscopic damage mechanisms of water‐bearing coal mass in the freeze‐thaw process with liquid nitrogen. For this purpose, by using a Zeiss microscope, a nonmetal ultrasonic velocity detector and a nuclear magnetic resonance (NMR) spectrometer, the changes in the structures of surface fractures and pores before and after coal masses with different moisture contents when subjected to freeze‐thaw treatment with liquid nitrogen (FTTLN) were tested. The result showed that under the freeze‐thaw effect of liquid nitrogen, the structures of surface fractures and internal pores of coal mass were both changed. Upon increasing the moisture content of the coal, the width of surface fractures increased; the surface fractures showed significant fractal characteristics: The higher the moisture content of the coal, the greater the rate of change of fractal dimension after FTTLN; the ultrasonic wave velocity in the coal mass gradually decreased after FTTLN, and the greater the moisture content, the more significant the decrease in ultrasonic wave velocity; under the freeze‐thaw effect of liquid nitrogen, the pore structure in the coal mass was transformed from micropores and small pores to mesopores and macropores and certain new micropores and small pores were generated. Upon increasing the moisture content of the coal mass, the peak area of micropores and small pores and their proportion decreased at first and then increased (reaching the minimum at 9.12% of moisture content); the peak area, peak area proportion, and porosity of mesopores and macropores always increased. The damage factor attained based on the width of fractures, longitudinal wave velocity, fractal dimension of surface fractures, and porosity was favorably correlated with the moisture content: With increasing moisture content, the coal mass became more severely damaged.
A theoretical and experimental study of passive computational radio frequency identification tags
Authors: Muralter Florian , Arjona Laura , Landaluce Hugo , Perallos Asier 
Published: March 2020

AbstractThe investigation and optimization of the RF frontend of radio frequency identification (RFID) tags represents a crucial topic when looking for an increased tag performance. This work studies the RF frontend of three state‐of‐the‐art passive computational RFID tags: AMS SL900a Dev Kit, Farsens Spider Eval, and WISP 5.1. Given a module‐based approach, the antenna, the matching network, the RF energy harvesting, and the load modulation are reviewed both theoretically and experimentally. The influence of a set of properties, corresponding to these modules, on the overall RFID tag performance is evaluated using a tag read range measurement.
Uptake prediction of ten heavy metals by Corchorus olitorius L. cultivated in soil mixed with sewage sludge
Authors: Eid Ebrahem M. , Shaltout Kamal H. , Alamri Saad A. M. , Sewelam Nasser A. , Galal Tarek M. 
Published: March 2020

AbstractThis study was carried out to develop mathematical regression equations for predicting the uptake of selected heavy metals (HMs: Cd, Co, Cr, Cu, Fe, Mn, Mo, Ni, Pb, and Zn) by Corchorus olitorius L. cultivated in soil mixed with sewage sludge based on the concentration of these HMs in the soil–sludge mixture, soil organic matter (OM), and soil pH. The resultant regression equations reflected that the three soil factors were significant predictors for the uptake of the ten HMs in the plant tissues. Applying the t test, there are no significant differences between the actual and predicted values of the ten HMs in C. olitorius root and shoot (p > .05), which reflect the best‐fitting of these equations for predicting the uptake of these HMs. Such types of equations may be helpful for evaluating the risk of cultivation due to precise prediction of C. olitorius (leafy vegetable) uptake of HMs, in soil mixed with sewage sludge.
Systemic chemotherapy and sequential locoregional radiotherapy in initially metastatic nasopharyngeal carcinoma: Retrospective analysis with 821 cases
Authors: Huang Tianying , Su Ning , Zhang Xuanye , Ma Shuyun , Zhong Guangzheng , Tian Xiaopeng , Chen Qiuyan , Tang Linglong , Lu Lixia , Fang Yu , Cai Jun , Cai Qingqing 
Published: March 2020

AbstractBackgroundWe designed this retrospective study to explore the best treatment modality for patients with initially metastatic nasopharyngeal carcinoma (NPC).MethodsFrom 2008 to 2017, 821 patients were enrolled. Treatment modalities and prognostic factors were analyzed.ResultsCompared with chemotherapy alone and radiotherapy‐based treatment, systemic chemotherapy‐sequential locoregional radiotherapy to the nasopharyngeal primary tumor site were associated with a significantly increased 3‐year overall survival (OS) rate (40.3%, 11.7%, and 22.9%, P < .001). The overall response rate of the paclitaxel combined with platinum and fluorouracil (TPF) regimen as first‐line chemotherapy was higher than that of the paclitaxel plus platinum (TP) regimen (78.2% vs 70.0%, P = .038). A better OS was achieved in the TPF group compared to doublet drug regimens (3‐year OS, 35.7% vs 25.3%, P < .001).ConclusionsSystemic chemotherapy‐sequential locoregional radiotherapy may prolong OS and progression‐free survival for selected patients with initially metastatic NPC.
SIRT1 Regulates N6‐Methyladenosine RNA Modification in Hepatocarcinogenesis by Inducing RANBP2‐Dependent FTO SUMOylation
Authors: Liu Xiaoming , Liu Jianye , Xiao Wen , Zeng Qinghai , Bo Hao , Zhu Yuxing , Gong Lian , He Dong , Xing Xiaowei , Li Ruhong , Zhou Ming , Xiong Wei , Zhou Yanhong , Zhou Jianda , Li Xiaohui , Guo Fei , Xu Canxia , Chen Xiong , Wang Xiaoyan , Wang Fen , Wang Qiang , Cao Ke 
Published: March 2020

Background and Aims
Hepatocellular carcinoma (HCC) is associated with high malignancy rates. Recently, a known deacetylase silent information regulator 1 (SIRT1) was discovered in HCC, and its presence is positively correlated with malignancy and metastasis. N6‐methyladenosine (m6A) is the most prominent modification, but the exact mechanisms on how SIRT1 regulates m6A modification to induce hepatocarcinogenesis remain unclear.

Approach and Results
Here we demonstrate that SIRT1 exerts an oncogenic role by down‐regulating fat mass and obesity‐associated protein (FTO), which is an m6A demethylase. A crucial component of small ubiquitin‐related modifiers (SUMOs) E3 ligase, RANBP2, is activated by SIRT1, and it is indispensable for FTO SUMOylation at Lysine (K)‐216 site that promotes FTO degradation. Moreover, Guanine nucleotide‐binding protein G (o) subunit alpha (GNAO1) is identified as m6A downstream targets of FTO and tumor suppressor in HCC, and depletion of FTO by SIRT1 improves m6A+ GNAO1 and down‐regulates its mRNA expression.

Conclusions
We demonstrate an important mechanism whereby SIRT1 destabilizes FTO, steering the m6A+ of downstream molecules and subsequent mRNA expression in HCC tumorigenesis. Our findings uncover a target of SIRT1 for therapeutic agents to treat HCC.
A wearable noncontact free‐rotating hybrid nanogenerator for self‐powered electronics
Authors: Jiang Dongjie , Ouyang Han , Shi Bojing , Zou Yang , Tan Puchuan , Qu Xuecheng , Chao Shengyu , Xi Yuan , Zhao Chaochao , Fan Yubo , Li Zhou 
Published: March 2020

AbstractSelf‐powerability is a new trend in the development of portable devices. Harvesting biomechanical energy to power personal information electronics is of great significance. In this work, we report a wearable noncontact free‐rotating hybrid nanogenerator (WRG), which is constituted by a triboelectric nanogenerator and an electromagnetic generator. A continuous output over 2 seconds can be achieved during one instantaneous incentive by external force, which is improved by two orders of magnitude compared to other wearable nanogenerators due to its unique mechanical energy storage design. The WRG can be integrated into shoes to generate an output energy of 14.68 mJ in each stepping, which meets the power requirements of most personal information electronics. The wireless sensor, GPS, and smartphone can be powered by the WRG continuously. The WRG is expected to be applied in self‐powered information electronics extensively in the future.image
How Does Obesity Influence the Risk of Vertebral Fracture? Findings From the UK Biobank Participants
Authors: Luo Jin , Lee Raymond YW 
Published: March 2020

ABSTRACTObesity and osteoporotic‐related fractures are two common public health problems, although it is unclear how obesity affects the risk of vertebral fractures. The purpose of this study was to examine the association between different measures of obesity and the risk of vertebral fracture, and to establish the various clinical factors that can predict such risk. We analyzed data obtained from 502,543 participants in the UK Biobank (229,138 men and 273,405 women), aged 40 to 69 years. Imaging information was available in a subset of this cohort (5189 participants: 2473 men and 2716 women). We further examined how BMD and geometry of the vertebrae were related to body fat measures. It was shown that a larger waist circumference (WC), but not BMI, was associated with an increase in fracture risk in men, but in women, neither BMI nor WC affected the risk. Trunk fat mass, visceral adipose tissue (VAT) mass, and limb fat mass were negatively associated with vertebral body BMD and geometry in men and women. BMD and geometry are related to vertebral strength, but may not be directly related to the risk of fractures, which is also influenced by other factors. The binary logistic regression equation established in this study may be useful to clinicians for the prediction of vertebral fracture risks, and may provide further information to supplement the fracture risk assessment tool, which assesses general fracture risks. © 2020 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.