bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between sleep duration, insomnia, depression, anxiety and registry‐based school grades: A longitudinal study among high‐school students
Authors: Evanger Linn Nyjordet , Pallesen Ståle , Saxvig Ingvild West , Hysing Mari , Sivertsen Børge , Lie Stein Atle , Gradisar Michael , Bjorvatn Bjørn 
Published: December 2024

SummaryThis study explored the prospective associations between sleep patterns, mental health and registry‐based school grades among older adolescents. In the spring of 2019, 1st year high‐school students in Western Norway were invited to a survey assessing habitual sleep duration, insomnia, depression and anxiety. Sleep patterns, depression and anxiety were assessed using the Munich ChronoType Questionnaire, the Bergen Insomnia Scale, the Patient Health Questionnaire‐9, and the Generalized Anxiety Disorder‐7. Students consenting to data linkage with the county school authorities were re‐invited 2 years later. Registry‐based grade point averages for each of the included school years were accessed through the school authorities. The final longitudinal sample included 1092 students (65.1% girls; initial mean age 16.4 years). Data were analysed using linear mixed models. Longer school night sleep duration and less severe symptoms of insomnia, depression and anxiety were all associated with higher grade point averages at baseline in crude analyses. Shorter school night sleep duration, as well as more severe symptoms of insomnia and depression at baseline, all predicted worse grade point averages at 2‐year follow‐up when controlled for baseline grade point averages. [Correction added on 30 December 2024, after first online publication: In the preceding sentence, the word “better” has been corrected to “worse”.] By contrast, anxiety symptomatology at baseline was unrelated to changes in grade point averages over time. The longitudinal associations between school night sleep duration and insomnia symptoms on grade point averages were significant also when adjusted for sex and baseline symptoms of depression and anxiety. These findings indicate that shorter school night sleep duration and more severe insomnia symptoms predict lower grade point averages development over time, irrespective of co‐existing symptoms of depression and anxiety.
Association of obesity or metabolic syndrome with various allergic diseases: An overview of reviews
Authors: Kuniyoshi Yasutaka , Tsujimoto Yasushi , Banno Masahiro , Taito Shunsuke , Ariie Takashi , Kimoto Takeru 
Published: December 2024

SummaryThe relationship between obesity, metabolic syndrome, related disorders, and various allergic diseases remains unclear. An overview of reviews investigating potential associations between obesity or metabolic syndrome and various allergic diseases was conducted. MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were searched. Systematic reviews and meta‐analyses with summary effect size and corresponding 95% confidence intervals for at least one outcome (asthma, atopic dermatitis, and various allergic diseases) were included. This study encompassed 17 systematic review articles and 29 eligible meta‐analyses. All included meta‐analyses indicated a positive association between obesity/overweight and asthma. Three meta‐analyses from one review demonstrated a positive association between obesity/overweight and the risk of atopic dermatitis. However, no meta‐analyses focused on the associations between obesity/overweight or metabolic syndrome and allergic rhinitis, allergic conjunctivitis, or other allergic conditions. All included reviews employed poor methodology according to the AMSTAR‐2 assessment tools. Our findings suggest that obesity likely increases the risk of asthma. However, evidence for associations with other allergic diseases is limited. Furthermore, no meta‐analyses were conducted to assess the relationship between metabolic syndrome and allergic diseases. Further studies are necessary to elucidate the associations between obesity and the full spectrum of allergic diseases.
Overcoming barriers to interreligious peace: Determinants of preferences for religiously similar others in Togo and Sierra Leone
Authors: Köbrich Julia , Stark Tobias H. , Martinović Borja , Adiakpo Yawo Seyram 
Published: December 2024

AbstractPreferences to interact with similar others are a barrier to positive intergroup contact and, thus, peaceful intergroup relations. A growing literature investigated what shapes contact preferences but more research on changeable factors that can be targeted by interventions is needed. In this article, we focused on preferences for interacting with religiously similar others. To create an interface between practice and research, our hypotheses on changeable determinants of preferences are informed by qualitative interviews on everyday practices of peaceful coexistence in Togo and Sierra Leone. We expected inclusive religious ideas, adaptive coping and emotion regulation skills, and knowledge of outgroup religious practices to be related to weaker preferences for similar others. Further, we argued these associations may vary depending on neighborhood levels of interreligious peace. We tested our hypotheses using survey data (N = 1828) collected among Muslims and Christians in 50 neighborhoods of Lomé (Togo) and Freetown (Sierra Leone). We found that inclusive ideas and knowledge of outgroup practices were associated with weaker, and exclusive ideas with stronger, preferences for similar others. These findings mostly held across groups and countries. Coping and emotion regulation skills did not matter systematically and our hypotheses about the role of neighborhood‐level peace was refuted.
A compound of salicylates, copper and zinc increases coffee resistance against infection by Hemileia vastatrix
Authors: Vieira Brás Verônica , Castro Silva Leandro , Silva Bruno Nascimento , Lata‐Tenesaca Luis Felipe , Quadros Leonardo Packer , Rodrigues Fabrício Ávila 
Published: December 2024

AbstractCoffee leaf rust (CLR), caused by the biotrophic fungus Hemileia vastatrix, has greatly impacted coffee production worldwide due to reductions in yield. This study investigated the potential use of Re‐leaf® (salicylates [0.69%], copper [0.5%] and zinc [6%]) to reduce CLR severity by boosting host defence reactions. A 2 × 2 factorial experiment was arranged with plants sprayed with water (control) or Re‐leaf (induced resistance [IR] stimulus) and noninoculated or inoculated with H. vastatrix. In vitro assays showed germ tubes were not formed on urediniospores exposed to IR stimulus at 5–12.5 mL/L and urediniospore germination was significantly lower as rates increased. CLR severity was also significantly reduced compared to the control, with the area under CLR progress curve and intensity of fungal sporulation significantly lower by 96% and 92%, respectively, and incubation period higher by 54% compared to control. The IR stimulus‐sprayed and infected plants showed better photosynthetic performance, preservation of photosynthetic pigments, greater activity of defence‐related enzymes and a more robust antioxidative metabolism compared to water‐sprayed and infected ones. The higher concentration of superoxide anion radical for IR stimulus‐sprayed and infected leaves may intensify cell defence reactions besides having a fungistatic effect. These results strongly support the potential use of IR stimulus to boost defences in coffee tissues and hamper the infection process of H. vastatrix. Its fungistatic effect against germination of fungal urediniospores should also be considered as a strategy to reduce the amount of inoculum required to start a CLR epidemic under field conditions.
Presentación del Dossier Educación de la primera infancia y la ciudadanía
Authors: Adlerstein-Grimberg Cynthia , Vargas-González Ángela Patricia 
Published: December 2024

La ciudadanía se ha convertido en un foco de interés político, social y educativo de las agendas de la primera infancia (Ailwooda et al., 2011; Johansson, 2009; Millei & Imre, 2009). Con la ratificación internacional de la Convención de los Derechos del Niño CDN (UNICEF, 1989) y la consigna de que “no nacemos demócratas: aprendemos a serlo” (OREALC-UNESCO, 2017, p. 7), se impulsa, en el mundo, la educación para la ciudadanía como aspecto consustancial y prioritario de la educación inicial1 (PNUD, 2021). En este contexto, el dossier que presentamos a continuación visibiliza la emergencia reciente de un campo de investigación, no solo de políticas, que reconoce la ciudadanía y la educación ciudadana desde la primera infancia como procesos fundamentales para promover democracias sólidas e inclusivas.
Comparing Patellofemoral Kinematics Assessed With a Novel Muscle Actuator System and an Oxford Rig Using Noncadaveric Knees
Authors: Galley Alexandre , Vakili Samira , Borukhov Ilya , Lanting Brent , Piazza Stephen J. , Willing Ryan 
Published: December 2024

Abstract
Total knee replacement (TKR) failure, low patient satisfaction and high revision surgery rates may stem from insufficient preclinical testing. Conventional joint motion simulators for preclinical testing of TKR implants manipulate a knee joint in force, displacement, or simulated muscle control. However, a rig capable of using all three control modes has yet to be described in literature. This study aimed to validate a novel platform, the muscle actuator system (MAS), that can generate gravity-dependent, quadriceps-controlled squatting motions representative of an Oxford rig knee simulator and is mounted onto a force/displacement-control-capable joint motion simulator. Synthetic knee joint phantoms were created that comprised revision TKR implants and key extensor and flexor mechanism analogues, but no ligaments. The combined system implemented a constant force vector acting from simulated hip-to-ankle coordinates, effectively replicating gravity as observed in an Oxford rig. Quadriceps forces and patellofemoral joint kinematics were measured to assess the performance of the MAS and these tests showed high levels of repeatability and reproducibility. Forces and kinematics measured at a nominal patellar tendon length, and with patella alta and baja, were compared against those measured under the same conditions using a conventional Oxford rig, the Pennsylvania State Knee Simulator (PSKS). There was disagreement in absolute kinematics and muscle forces, but similar trends resulting from changing prosthesis design or patellar tendon length.
Continuous-Context, User-Independent, Real-Time Intent Recognition for Powered Lower-Limb Prostheses
Authors: Bhakta Krishan , Maldonado-Contreras Jairo , Camargo Jonathan , Zhou Sixu , Compton William , Herrin Kinsey R. , Young Aaron J. 
Published: December 2024

Abstract
Community ambulation is essential for maintaining a healthy lifestyle, but it poses significant challenges for individuals with limb loss due to complex task demands. In wearable robotics, particularly powered prostheses, there is a critical need to accurately estimate environmental context, such as walking speed and slope, to offer intuitive and seamless assistance during varied ambulation tasks. We developed a user-independent and multicontext, intent recognition system that was deployed in real-time on an Open Source Leg (OSL). We recruited 11 individuals with transfemoral amputation, with seven participants used for real-time validation. Our findings revealed two main conclusions: (1) the user-independent (IND) performance across speed and slope was not statistically different from user-dependent (DEP) models in real-time and did not degrade compared to its offline counterparts, and (2) IND walking speed estimates showed ∼0.09 m/s mean absolute error (MAE) and slope estimates showed ∼0.95 deg MAE across multicontext scenarios. Additionally, we provide an open-source dataset to facilitate further research in accurately estimating speed and slope using an IND approach in real-world walking tasks on a powered prosthesis.
Tribological Analysis and Thermal Behavior of Gear Tooth Flanks in Polymer Gears During Dry Operation
Authors: Alharbi Khalid Abdulkhaliq M. 
Published: December 2024

Abstract
This study presents comprehensive findings on the tribological and thermal behavior of polymer gears under varying loads and operating conditions. Gear tooth wear-rates and thermal contact behavior were investigated for nylon (PA) and acetal (POM) materials, fabricated using machining (MC). Experimental investigations were performed under loads of 6.5 N m, 8.5 N m, and 9.0 N m, while maintaining a consistent rotational velocity of 1500 rpm. The wear-rates and surface temperatures were systematically monitored utilizing a linear variable differential transformer (LVDT) with a precision of 0.1 µm and a high-resolution thermal imaging apparatus. Results revealed that at 9.0 N m, thermal stabilization reduced wear-rates by 15% compared to 8.5 N m, due to the softened material layer acting as an internal lubricant. Conversely, higher wear-rates at 8.5 N m were attributed to localized debris formation and limited thermal softening. Key findings include the identification of the glass transition temperature of PA at approximately 75 °C and its effect on wear behavior. These insights provide a deeper understanding of polymer gear performance, offering guidance for material selection and operational optimization in high-performance applications.
Taxonomic diversity and functional potential of microbial communities in oyster calcifying fluid
Authors: Unzueta-Martínez Andrea , Girguis Peter R. 
Published: December 2024

ABSTRACT

Creating and maintaining an appropriate chemical environment is essential for biomineralization, the process by which organisms precipitate minerals to form their shells or skeletons, yet the mechanisms involved in maintaining calcifying fluid chemistry are not fully defined. In particular, the role of microorganisms in facilitating or hindering animal biomineralization is poorly understood. Here, we investigated the taxonomic diversity and functional potential of microbial communities inhabiting oyster calcifying fluid. We used shotgun metagenomics to survey calcifying fluid microbial communities from three different oyster harvesting sites. There was a striking consistency in taxonomic composition across the three collection sites. We also observed archaea and viruses that had not been previously identified in oyster calcifying fluid. Furthermore, we identified microbial energy-conserving metabolisms that could influence the host’s calcification, including genes involved in sulfate reduction and denitrification that are thought to play pivotal roles in inorganic carbon chemistry and calcification in microbial biofilms. These findings provide new insights into the taxonomy and functional capacity of oyster calcifying fluid microbiomes, highlighting their potential contributions to shell biomineralization, and contribute to a deeper understanding of the interplay between microbial ecology and biogeochemistry that could potentially bolster oyster calcification.

IMPORTANCE
Previous research has underscored the influence of microbial metabolisms in carbonate deposition throughout the geological record. Despite the ecological importance of microbes to animals and inorganic carbon transformations, there have been limited studies characterizing the potential role of microbiomes in calcification by animals such as bivalves. Here, we use metagenomics to investigate the taxonomic diversity and functional potential of microbial communities in calcifying fluids from oysters collected at three different locations. We show a diverse microbial community that includes bacteria, archaea, and viruses, and we discuss their functional potential to influence calcifying fluid chemistry via reactions like sulfate reduction and denitrification. We also report the presence of carbonic anhydrase and urease, both of which are critical in microbial biofilm calcification. Our findings have broader implications in understanding what regulates calcifying fluid chemistry and consequentially the resilience of calcifying organisms to 21st century acidifying oceans.
Temperature-responsive regulation of the polycyclic aromatic hydrocarbon-degrading mesophilic bacterium
Novosphingobium pentaromativorans
US6-1 with a temperature adaptation system
Authors: Liu Zhuangzhuang , Liu Xinran , Huang Haiyan , Cao Feifei , Meng Qiu , Zhu Tingheng , Yin Jianhua , Song Xiaofei , Yu Zhiliang 
Published: December 2024

ABSTRACT

Survivability and tolerance of polycyclic aromatic hydrocarbon (PAH)-degrading bacteria in harsh environments, especially under varying temperatures, are a bottleneck for the effective application of
in situ
bioremediation. In this study, a temperature adaptation system (TAS) was constructed by combining a customized thermotolerant system with a customized cold-resistant system to realize the temperature-responsive regulation of the PAH-degrading mesophilic bacterium
Novosphingobium pentaromativoran
s US6-1. The innovative dual-pronged TAS strategy enabled the chassis strain to effectively tackle conditions under varying temperatures, ensuring robust biological activities across a broadened temperature spectrum and exhibiting the potential to realize the high-efficiency PAH degradation of
N. pentaromativorans
US6-1 in
in situ
bioremediation. Furthermore, the temperature-responsive regulation achieved using the TAS circuit is likely promising for creating intelligent microbial cell factories and avoiding precise temperature maintenance, making it highly useful for industrial applications.

IMPORTANCE

Environmental temperature is among the extremely important factors that determine the bioactivities of pollutant-degrading microorganisms in
in situ
bioremediation. Effectively maintaining the survivability and tolerance of mesophilic microorganisms under harsh conditions and varying temperatures remains a challenge in the application of pollutant bioremediation. This study, for the first time, developed a temperature adaptation system by combining a customized thermotolerant system with a customized cold-resistant system to realize the temperature-responsive regulation of the polycyclic aromatic hydrocarbon (PAH)-degrading mesophilic bacterium
Novosphingobium pentaromativoran
s US6-1, thus diminishing the need for precise temperature control in PAH bioremediation.
Non-lytic spread of poliovirus requires the nonstructural protein 3CD
Authors: Aponte-Diaz David , Harris Jayden M. , Kang Tongjia Ella , Korboukh Victoria , Sotoudegan Mohamad S. , Gray Jennifer L. , Yennawar Neela H. , Moustafa Ibrahim M. , Macadam Andrew , Cameron Craig E. 
Published: December 2024

ABSTRACT

Non-enveloped viruses like poliovirus (PV) have evolved the capacity to spread by non-lytic mechanisms. For PV, this mechanism exploits the host secretory autophagy pathway. Virions are selectively incorporated into autophagosomes, double-membrane vesicles that travel to the plasma membrane, fuse, and release single-membrane vesicles containing virions. Loading of cellular cargo into autophagosomes relies on direct or indirect interactions with microtubule-associated protein 1B-light chain 3 (LC3) that are mediated by motifs referred to as LC3-interaction regions (LIRs). We have identified a PV mutant with a severe defect in non-lytic spread. An F-to-Y substitution in a putative LIR of the nonstructural protein 3CD prevented virion incorporation into LC3-positive autophagosomes and virion trafficking to the plasma membrane for release. Using high-angle annular dark-field scanning transmission electron microscopy to monitor PV-induced autophagosome biogenesis, for the first time, we show that virus-induced autophagic signals yield normal autophagosomes, even in the absence of virions. The F-to-Y derivative of PV 3CD was unable to support normal autophagosome biogenesis. Together, these studies make a compelling case for the direct role of a viral nonstructural protein in the formation and loading of the vesicular carriers used for non-lytic spread that may depend on the proper structure, accessibility, and/or dynamics of its LIR. The studies of PV 3CD protein reported here will hopefully provoke a more deliberate look at the presence and function of LIR motifs in viral proteins of viruses known to use autophagy as the basis for non-lytic spread.

IMPORTANCE
Poliovirus (PV) and other enteroviruses hijack the cellular secretory autophagy pathway for non-lytic virus transmission. While much is known about the cellular factors required for non-lytic transmission, much less is known about viral factors contributing to transmission. We have discovered a PV nonstructural protein required for multiple steps of the pathway leading to vesicle-enclosed virions. This discovery should facilitate the identification of the specific steps of the cellular secretory autophagy pathway and corresponding factors commandeered by the virus and may uncover novel targets for antiviral therapy.
Supplemental Material: Mesoproterozoic oxygenation event: From shallow marine to atmosphere
Authors: Xie Baozeng , Tang Dongjie , al. et 
Published: December 2024

<p>Table S1: Geochemical data from Member II and III of the Gaoyuzhuang Formation in the Yanqing and Jixian Sections, North China. Table S2: δ34SCAS, CAS, Mg/Ca, δ18Ocarb, Mn/Sr and I/(Ca+Mg) values of carbonates from the Gaoyuzhuang Formation in the Yanqing Section, North China. Mg/Ca, δ18Ocarb, Mn/Sr and I/(Ca+Mg) data are from Shang et al. (2019). </p>
Reduced maternal–fetal cardiac coupling in moderate preterm labor: a high-resolution symbolic dynamics analysis
Authors: Piña-Martínez Michael Moncerrat , Pliego-Carrillo Adriana Cristina , Ledesma-Ramírez Claudia Ivette , Echeverría Juan Carlos , Mendieta-Zerón Hugo , Santiago-Fuentes Laura Mercedes , Abarca-Castro Eric Alonso , Talavera-Peña Ana Karen , Reyes-Lagos José Javier 
Published: December 2024

AbstractThis research explores maternal–fetal heart rhythm coupling (MFHRC) in full-term and moderate preterm labor using high-resolution joint symbolic dynamics (HRJSD) to identify distinct heart rate patterns indicative of physiological system couplings during active labor stages. This study evidences that preterm labor exhibits unique MFHRC patterns compared to full-term labor, potentially reflecting physiological responses and system complexities differences. The analysis involved 25 maternal–fetal RR time series from women in active full-term labor and 18 from those in moderate preterm labor. HRJSD was utilized to dissect the degree of coupling by examining specific maternal–fetal heart rhythm patterns and calculating global Shannon entropy for both groups. We observed that specific dominant heart rate patterns are preserved in both term and moderate preterm labor, suggesting an intrinsic aspect of cardiovascular coupling irrespective of the labor's condition. Additionally, we found variations in non-dominant patterns between term and preterm labor, which may reflect subtle differences in cardiac responses, hinting at possible adaptive fetal strategies in response to preterm labor conditions. An important finding of our research is the overall decrease in MFHRC in preterm labor, as indicated by higher Shannon entropy values. This decrease suggests a reduced synchronization of maternal–fetal heart rate rhythm during labor in preterm conditions. These insights highlight the importance of MFHRC analysis in understanding the distinct physiological interactions between mother and fetus during labor. The study's findings may pave the way for further research on prenatal health and developing interventions that may guide outcomes in preterm labor.