bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human islet amyloid polypeptide (hIAPP) - a curse in type II diabetes mellitus: insights from structure and toxicity studies
Authors: Bishoyi Ajit Kumar , Roham Pratiksha H. , Rachineni Kavitha , Save Shreyada , Hazari M. Asrafuddoza , Sharma Shilpy , Kumar Ashutosh 
Published: August 2020

AbstractThe human islet amyloid polypeptide (hIAPP) or amylin, a neuroendocrine peptide hormone, is known to misfold and form amyloidogenic aggregates that have been observed in the pancreas of 90% subjects with Type 2 Diabetes Mellitus (T2DM). Under normal physiological conditions, hIAPP is co-stored and co-secreted with insulin; however, under chronic hyperglycemic conditions associated with T2DM, the overexpression of hIAPP occurs that has been associated with the formation of amyloid deposits; as well as the death and dysfunction of pancreatic β-islets in T2DM. Hitherto, various biophysical and structural studies have shown that during this process of aggregation, the peptide conformation changes from random structure to helix, then to β-sheet, subsequently to cross β-sheets, which finally form left-handed helical aggregates. The intermediates, formed during this process, have been shown to induce higher cytotoxicity in the β-cells by inducing cell membrane disruption, endoplasmic reticulum stress, mitochondrial dysfunction, oxidative stress, islet inflammation, and DNA damage. As a result, several research groups have attempted to target both hIAPP aggregation phenomenon and the destabilization of preformed fibrils as a therapeutic intervention for T2DM management. In this review, we have summarized structural aspects of various forms of hIAPP viz. monomer, oligomers, proto-filaments, and fibrils of hIAPP. Subsequently, cellular toxicity caused by toxic conformations of hIAPP has been elaborated upon. Finally, the need for performing structural and toxicity studiesin vivoto fill in the gap between the structural and cellular aspects has been discussed.
Redox-dependent and independent effects of thioredoxin interacting protein
Authors: Cao Xiankun , He Wenxin , Pang Yichuan , Cao Yu , Qin An 
Published: August 2020

AbstractThioredoxin interacting protein (TXNIP) is an important physiological inhibitor of the thioredoxin (TXN) redox system in cells. Regulation of TXNIP expression and/or activity not only plays an important role in redox regulation but also exerts redox-independent physiological effects that exhibit direct pathophysiological consequences including elevated inflammatory response, aberrant glucose metabolism, cellular senescence and apoptosis, cellular immunity, and tumorigenesis. This review provides a brief overview of the current knowledge concerning the redox-dependent and independent roles of TXNIP and its relevance to various disease states. The implications for the therapeutic targeting of TXNIP will also be discussed.
From the Middle Ages Back to Antiquity: The Reception of the Idea of Dynamic Unity in the Gospel of John as Entanglement of Intellectual Traditions
Authors: Casteigt Julie 
Published: August 2020

Abstract
This article studies Albert the Great’s conception of reciprocal interiority in the exposition of John 14:10: “Do you not believe that I am in the Father and the Father is in me? The words that I say to you I do not speak on my own; but the Father who dwells in me does his works” (Bible quotes from the New Revised Standard Version (NRSV)). Firstly, the article explores how Albert the Great understands reciprocal interiority as an element of the debate concerning the equality of the Father and of the Son, who, although identical in nature, are different according to the relation, like the one who begets and the one who is begotten. Secondly, it emphasizes the metaphysical solution that Albert borrows from Greek-Arabic neoplatonism, especially from the Liber de causis, so as to refute an objection based on Aristotle’s conception of place. This cultural transfer brings to light how Albert the Great’s Super Iohannem is an innovative melting pot in which Albert imports a new framework from profane sciences, with which to interpret the Gospel of John.
A nonsense variant in FGFR1: a rare cause of combined pituitary hormone deficiency
Authors: Erbaş İbrahim Mert , Paketçi Ahu , Acar Sezer , Kotan Leman Damla , Demir Korcan , Abacı Ayhan , Böber Ece 
Published: August 2020

Abstract

Objectives
Variants in fibroblast growth factor receptor-1 (FGFR1) may either cause isolated hypogonadotropic hypogonadism (IHH) or Kallmann syndrome (KS). Although the relationship of genes classically involved in IHH with combined pituitary hormone deficiency (CPHD) is well established, variants in FGFR1 have been presented as a rare cause of this phenotype recently.

Case presentation
Herein, we report an adopted 16-year-old male presented with delayed puberty and micropenis. He had undergone surgery for bilateral undescended testes in childhood. He was normosmic, and the pituitary imaging was normal. However, hypogonadotropic hypogonadism and growth hormone deficiency were detected, associated with a heterozygous nonsense variant (c.1864 C>T, p.R622X) in FGFR1.

Conclusions

FGFR1 variants are among the causes of IHH and KS, which are inherited in an autosomal dominant manner and can be associated with midline defects. It should also be kept in mind that CPHD may be associated with FGFR1 variants in a subject with normal olfactory function.
Association between handgrip strength and cardiovascular risk factors among Korean adolescents
Authors: Kim Kyoung Kon , Lee Kyu Rae , Hwang In Cheol 
Published: August 2020

Abstract

Background
It remains unclear whether muscle strength, which reduces cardiovascular (CV) risk in adults, is associated with similar protection in Asian adolescents. This study investigated the association between handgrip strength and CV health in a large Korean sample of school-age adolescents.

Methods
We performed a cross-sectional analysis of adolescents aged 10–18 years (n=4,018) from the Korean National Health and Nutrition Survey between 2014 and 2017. Handgrip strength was measured using a dynamometer. CV risk factors include waist circumference, blood pressure, fasting glucose or hemoglobin A1c, and lipid levels. Logistic regression models were applied with adjustment for potential confounders.

Results
The mean age of participants was 14.0 years, and 53.6% were boys. Mean handgrip strength was 30.4 kg for boys and 22.0 kg for girls. Boys more frequently had high systolic blood pressure and impaired fasting glucose, whereas girls more frequently had low high-density lipoprotein cholesterol. Multivariate logistic regression analysis revealed that in boys only, handgrip strength was negatively associated with central obesity and hypertriglyceridemia and positively associated with higher systolic blood pressure.

Conclusion
Handgrip strength is independently associated with some CV risk factors only in boys.
First record of a Nathusius’ pipistrelle (Pipistrellus nathusii) overwintering at a latitude above 60°N
Authors: Blomberg Anna S. , Vasko Ville , Salonen Saku , Pētersons Gunārs , Lilley Thomas M. 
Published: August 2020

Abstract
Highly mobile species are considered to be the first to respond to climate change by transforming their ranges of distribution. There is evidence suggesting that Pipistrellus nathusii, a species capable of long-distance migration, is expanding both its reproduction and overwintering ranges to the North. We recorded the echolocation calls of bats at 16 sites in South-Western Finland on two consecutive winters, and detected calls of P. nathusii at one of the sites throughout the second winter. To our knowledge, this is the northernmost record of an overwintering P. nathusii, and contributes to evidence that the species is already responding to climate change.
Jordan {g,h}-derivations on triangular algebras
Authors: Kong Liang , Zhang Jianhua 
Published: August 2020

Abstract
In this article, we give a sufficient and necessary condition for every Jordan {g,h}-derivation to be a {g,h}-derivation on triangular algebras. As an application, we prove that every Jordan {g,h}-derivation on

τ
(
N
)

\tau ({\mathscr{N}})

is a {g,h}-derivation if and only if

dim

0

+

≠
1

\dim {0}_{+}\ne 1

or

dim

H

−

⊥

≠
1

\dim {H}_{-}^{\perp }\ne 1

, where

N

{\mathscr{N}}

is a non-trivial nest on a complex separable Hilbert space H and

τ
(
N
)

\tau ({\mathscr{N}})

is the associated nest algebra.
The crystal structure 2,2′-bipyridine-κ2
N,N′-(2-(3-amino-4-chlorobenzoyl)benzoato-κ1
O)-(2-(3-amino-4-chlorobenzoyl)benzoato-κ2
O,O′)zinc(II) — ethanol (1/1), C40H32Cl2N4O7Zn
Authors: Li-Hua Wang , Lei Liang , Xi-Shi Tai 
Published: August 2020

Abstract
C40H32Cl2N4O7Zn, monoclinic, P21/c (no. 14), a = 13.5114(8) Å, b = 16.5735(7) Å, c = 17.0403(9) Å, β = 107.528(6)°, V = 3638.7(3) Å3, Z = 4, R
gt(F) = 0.0398, wR
ref(F
2) = 0.0831, T = 100 K.
Crystal structure of catena-poly[(μ2-1-((benzotriazol-1-yl)methyl)-1H-1,3-imdazole-κ2
N:N′)-(1-((benzotriazol-1-yl)methyl)-1H-1,3-imdazole-κ1N)-(methanol-κ1
O)mercury(II)] dinitrate, C21H22N12O7Hg
Authors: Sun Shu-Xiang , Lu Zhi-Min , Zhang Ke-Qing , Yao Pei 
Published: August 2020

Abstract
C21H22N12O7Hg, monoclinic, P2/n (no. 13), a = 13.655(3) Å, b = 8.7038(17) Å, c = 23.260(5) Å, β = 102.51(3)°, V = 2698.8(10) Å3, Z = 4, R
gt(F) = 0.0446, wR
ref(F
2) = 0.0875, T = 293(2) K.
Crystal structure of 3-ethyl-1-[(E)-[(2E)-3-phenylprop-2-en-1-ylidene]amino]thiourea, C12H15N3S
Authors: Tan Ming Yueh , Ho Sheng Zhou , Tan Kong Wai , Tiekink Edward R.T. 
Published: August 2020

Abstract
C12H15N3S, orthorhombic, Pbca (no. 61), a = 11.9612(5) Å, b = 8.1215(3) Å, c = 27.5865(12) Å, V = 2679.83(19) Å3, Z = 8, R
gt(F) = 0.0520, wR
ref(F
2) = 0.1514, T = 293(2) K.
Crystal structure of 4,4′-bipyridin-1,1′-dium poly[bis(μ4-benzene-1,3,5-triyltris(hydrogen phosphonato-κ4
O:O′:O′′:O′′′))zinc(II)], C11H11NO9P3Zn
Authors: Sun Yabin , Chen Yan , Wang Daguang 
Published: August 2020

Abstract
C11H11NO9P3Zn, monoclinic, P21/n (no. 14), a = 12.619(2) Å, b = 8.4948(12) Å, c = 13.954(2) Å, β = 90.588(3)°, V = 1495.7(4) Å3, Z = 4, R
gt(F) = 0.0413, wR
ref(F
2) = 0.0965, T = 120(2) K.
Crystal structure of 2-(pyridin-2-ylamino)pyridinium chloride dibenzyldichlorostannane, [C10H10N3]Cl, C14H14Cl2Sn
Authors: Lee See Mun , Lo Kong Mun , Tiekink Edward R.T. 
Published: August 2020

Abstract
C24H24Cl3N3Sn, triclinic, P1̄ (no. 2), a = 10.2029(2) Å, b = 10.6071(2) Å, c = 12.1389(3) Å, α = 71.395(2)°, β = 82.665(2)°, γ = 73.340(2)°, V = 1191.84(5) Å3, Z = 2, R
gt(F) = 0.0175, wR
ref(F
2) = 0.0447, T = 100(2) K.
Infrastructure, Urban Sprawl, and Naturally-Occurring Asbestos: An Ontological Thought Model for Wicked and Saving Technologies
Authors: Epting Shane 
Published: August 2020

Abstract
Recently, geologists in Southern Nevada discovered new deposits of naturally occurring asbestos and microscopic fibers in rocks and soil. The danger is that inhaling them can lead to mesothelioma. One problem is that this rare cancer often takes decades to manifest. This discovery abruptly stalled a highway project near Las Vegas. Due to this condition, management developed numerous protocols to keep workers safe. Using this case as a “thought model,” the author challenges an established way of categorizing kinds of technologies as they relate to the concept of being. In turn, this thought model reveals that climate change alters the conditions for being, as recognized in the literature. Advancing this conversation requires that we must reclassify some technologies and develop a categorization for those that reflect a different way of thinking as it concerns being.
Technique of neuromonitoring during pelvic peritonectomy
Authors: Macrì Antonio , Badessi Giorgio , Mazzeo Carmelo , Galati Marica , Cucinotta Eugenio , Rizzo Vincenzo 
Published: August 2020

AbstractObjectivesPelvic peritonectomy can induce anorectal and urogenital dysfunctions. To reduce this type of complications during the procedure, we propose to use intraoperative neuromonitoring (IONM).ContentStimulation with a bipolar probe allows the identification of the obturator and ilioinguinal and pudendal nerves. At the end of the cytoreductive surgery, the motor and somatosensory evoked potentials must be evaluated to confirm the preservation of pelvic innervation.SummaryThe use of IONM during pelvic peritonectomy is technically feasible, and it can help to preserve pelvic nerves.OutlookObviously, its definitive value remains to be elucidated.
Influence of Images in Online Reviews for Search Goods on Helpfulness
Authors: Osterbrink Lars , Alpar Paul , Seher Alexander 
Published: August 2020

AbstractReviewing and rating are important features of many social media websites, but they are found on many e-commerce sites too. The combination of social interaction and e-commerce is sometimes referred to as social commerce to indicate that people are supporting each other in the process of buying goods and services. Rgeviews of other consumers have a significant effect on consumer choice because they are usually considered authentic and more trustworthy than information presented by a vendor. The collaborative effort of consumers helps to make the right purchase decision (or prevent from a wrong one). The effect of reviews has often been researched in terms of helpfulness as indicated by their readers. Images are an important factor of helpfulness in reviews of experience goods where personal tastes and use play an important role. We extend this research to search goods where objective characteristics seem to prevail. In addition, we analyze potential interaction with other variables. The empirical study is performed with regression analyses on 3,483 search good reviews from Amazon.com followed by a matched pair analysis of 186 review pairs. We find that images have a significant positive effect on helpfulness of reviews of search goods too. This is especially true in case of short and ambiguous reviews.
Mixed Matrix Membranes prepared from polysulfone and Linde Type A zeolite
Authors: Jacas-Rodríguez A. , Rodríguez-Pascual P. , Franco-Manzano D. , Contreras L. , Polop C. , Rodriguez M. A. 
Published: August 2020

Abstract
This work focuses on dip coating and further phase inversion prepared polysulfone/LTA zeolite mixed matrix membranes (MMMs). The Linde Type A (LTA) zeolite synthesized under hydrothermal conditions by the organic free method was introduced as fillers at 10 and 20 wt.% loadings into the polysulfone polymer matrix to obtain MMMs. The x-ray diffraction (XRD) and scanning electron microscopy (SEM) analysis indicated that the as-synthesized LTA zeolite samples were crystalline and mainly composed of crystal of predominantly cubic shape. Textural characterisation using Ar adsorption/desorption data of LTA zeolite shown the existence of mesoporous. Atomic force microscopy (AFM) in combination with the SEM characterised the membrane morphology and the dispersion of zeolite fillers. The effect of the zeolite loading on the performance of the MMMs was analysed. It points out that N2 permeability was increased with the increment of zeolite filler, also the high membranes permeability and the weak dependence upon transmembrane pressure and therefore its high selectivity. The average membrane thickness was 150 μm.
L2 Acquisition of Spanish VOT by English-Speaking Immigrants in Spain
Authors: Face Timothy L. , Menke Mandy R. 
Published: August 2020

AbstractPrevious studies of native English speakers learning Spanish as a second language (L2) document compromise voice onset time (VOT) values; however, the focus has been predominantly on voiceless stops and has almost exclusively investigated beginning and intermediate learners. This study fills a gap in the literature by considering the acquisition of VOT in both voiceless and voiced Spanish stops by long-time native English-speaking residents of Spain. Overall, the results show that the L2 speakers’ VOT values differ from those of native speakers across all stop consonants; yet L2 speakers’ productions of voiceless, as opposed to voiced, stops more closely approximate those of native speakers. Considerable individual variation is observed as no speaker achieves native-like performance overall, and no consonant is mastered by more than half of the speakers. Results are considered in light of what they contribute to our understanding of ultimate attainment of Spanish VOT, specifically, and L2 phonology more generally.
A diachronic and areal typology of agreement in Germanic
Authors: Birkenes Magnus Breder , Fleischer Jürg , Leser-Cronau Stephanie 
Published: August 2020

AbstractIn a comparison of a passage from the New Testament (Luke 2:1–2:20), we explore diachronic developments and areal distributions of agreement in Germanic quantitatively by taking into account 33 different Bible versions, spanning from Wulfila’s Gothic version to all modern standard languages and selected dialects. This allows us to establish a thorough typological profile of agreement and its differing developments in Germanic. Our method involves a quantification of all agreement relations, allowing for precise comparisons.
Kasus im Namdeutschen
Authors: Zimmer Christian 
Published: August 2020

AbstractThis paper focusses on case marking in informal Namibian German (so calledNamdeutsch). Whilst the use of nominative and accusative case is stable and similar to Standard German, there is a considerable amount of variation with regard to the dative case. This phenomenon is analysed in detail using corpus and questionnaire data. Multifactorial analyses reveal that several sociolinguistic and grammatical factors have a significant impact on the language use in this particular domain. Subsequently, the results are compared with other extraterritorial varieties of German and various similarities are found. This supports the idea that there are variety/language overarching principles at work.
Syntheses and crystal structures of the manganese hydroxide halides Mn5(OH)6Cl4, Mn5(OH)7I3, and Mn7(OH)10I4
Authors: Falkowski Viktoria , Zeugner Alexander , Seidel Stefan , Pöttgen Rainer , Wurst Klaus , Ruck Michael , Huppertz Hubert 
Published: August 2020

Abstract
Single-crystals of the new manganese hydroxide halides Mn5(OH)6Cl4, Mn5(OH)7I3, and Mn7(OH)10I4 were obtained by means of high-pressure/high-temperature synthesis in a Walker-type multianvil apparatus. The chloride crystallizes in the monoclinic space group P21/c (no. 14) with the lattice parameters (single-crystal data) a = 592.55(8), b = 1699.7(2), c = 597.33(8) pm, and β = 112.58(1)°. The iodides crystallize in the triclinic space group P

1
‾

$\bar{1}$

(no. 2) with a = 653.16(2), b = 905.98(3), c = 1242.98(4) pm, α = 114.21(1)°, β = 99.91(1)°, and γ = 94.37(1)° for Mn5(OH)7I3 and a = 656.90(3), b = 906.59(4), c = 909.32(4) pm, α = 119.29(1)°, β = 97.99(1)°, and γ = 95.03(1)° for Mn7(OH)10I4. The crystal structures consist of edge-sharing Mn(OH)6–n
X
n (X = Cl, I; n = 1, 2, 3) octahedra arranged in stacked sheets. Adjacent layers are connected by hydrogen bonds of type O–H···X, confirmed by further characterization of single-crystals by IR-spectroscopy. The crystal chemical relationship with the aristotype Mg(OH)2 (brucite) is discussed on the basis of Bärnighausen trees (group–subgroup relations).
Syntheses and crystal structures of solvate complexes of alkaline earth and lanthanoid metal iodides with N,N-dimethylformamide
Authors: Hoch Constantin 
Published: August 2020

Abstract
The solvate complexes that can be obtained by either dissolving metal iodides in N,N-dimethylformamide (DMF) or by synthesising them in DMF have the general composition [M(DMF)
x
]I
y
. DMF shows to behave as simple monodentate ligand with low sterical impact, so that x in the composition follows the radius of M

y+. We present here the crystal structures of the alkaline earth and lanthanoid metal iodide complexes [Mg(DMF)6]I2, [Ca(DMF)6]I2, [Sr(DMF)7]I2, [Ba(DMF)8]I2, [La(DMF)9]I3, [Ln(DMF)8]I3 (isotypic series for Ln = Nd, Sm, Eu, Dy, Gd, Er, Yb and Lu) and for the tris-triiodide complex salt [Sc(DMF)6](I3)3. Their different crystal structure types can be compared on the basis of the packing topologies of the nearly spherical cationic entities which show simple sphere packing motifs.
Das Sondergericht Kattowitz 1939–1945, Organisation und Besetzung
Authors: Graczyk Konrad 
Published: August 2020

Abstract

The Special Court in Katowice 1939–1945. Organizational structure and cadres. The article is devoted to the Special Court in Katowice operating in a specific area of Upper Silesia during World War II. In the basic scope, the issue of special courts created in the Third Reich and the creation of the title ‘special court’ is discussed. Then its structure and judges are analyzed in detail.
Ziel des Artikels ist es, die Organisationsstruktur und die Besetzung des Sondergerichts in Kattowitz zu skizzieren. Den für dieses Gericht spezifischen Überlegungen, die sich in erster Linie auf die Primärquellenforschung stützen, sollten jedoch einleitende Bemerkungen vorausgehen. Diese können das Wesen der nationalsozialistischen Sondergerichte erklären. Die Quellengrundlage der eingehenden Erwägungen bilden Personalakten der deutschen Richter, die im Bundesarchiv Berlin, im Bestand R 3001: Reichsjustizministerium, und im Geheimen Staatsarchiv Preußischer Kulturbesitz Berlin-Dahlem, im Bestand der XVII. Hauptabteilung [HA]: Schlesien, Rep. 222a: Oberamtsregierung, Appellationsgericht bzw. Oberlandesgericht Breslau [zit. GStAPK XVII/222a], aufbewahrt werden. Die Identität der Mitarbeiter des Sondergerichts war dagegen auf Grund von Archivalien des Sondergerichts feststellbar, die das Staatsarchiv in Kattowitz im Bestand Nr. 134 Sondergericht Kattowitz (nur Strafsachenakten)
Im Lichte des zur Verfügung stehenden Aktenmaterials, das nicht nur die in Kattowitz aufbewahrten Archivalien, sondern auch in Berlin aufbewahrte Urteilsabschriften umfasste, ist festzustellen, dass das Sondergericht Kattowitz mindestens 2394 Sachen erledigt hat, in denen 3625 Personen angeklagt waren. Verurteilt wurden 3180 Personen, davon 1391 Personen zu einer Gefängnisstrafe (ggf. zu gleichwertiger Straflagerstrafe), 1506 zu einer Zuchthausstrafe (ggf. zu gleichwertiger verschärfter Straflagerstrafe) und 247 Personen zur Todesstrafe. Freigesprochen wurden 333 Personen, in Bezug auf 49 Personen wurde das Verfahren eingestellt und gegenüber 42 vorläufig eingestellt. Aufgrund des Zustands der meisten Urteile konnten detaillierte Rechtsprechungsstudien durchgeführt werden, deren Ergebnisse eine gesonderte Veröffentlichung verdienen. Die Rechtsprechung des Sondergerichts wurde vom Autor in der Doktorarbeit zum Thema „Sondergericht Kattowitz 1939–1945“ bearbeitet. Die Doktorarbeit wurde am 16. September 2019 verteidigt und am 30. September 2019 durch den Rat der Fakultät für Rechtswissenschaften und Verwaltung der Schlesischen Universität in Kattowitz mit Auszeichnung behandelt. Der Autor beabsichtigt, die Dissertation zu ergänzen, zu verbessern und in deutscher Sprache zu veröffentlichen.
) verwahrt. Da diese Archivalien keine Organisations- und Verwaltungsakten umfassen, wurden die diesbezüglichen Feststellungen auf der Grundlage des Inhalts der Personalakten getroffen.
Defining Boundaries in the Treaty of Apamea. A Note on a New Edition of Livy’s Fourth Decade
Authors: Gygax Marc Domingo 
Published: August 2020

Abstract
This contribution deals with Livy’s account of the peace treaty of Apamea between Rome and Antiochus III (189/188 BC), and in particular with Liv. 37,56,1–6, which treats the division of the Seleucid dominions in Asia Minor between Eumenes II and the Rhodians. With attention to Yardley’s new Loeb edition and translation of Livy’s fourth decade, it discusses grammatical problems and questions of textual transmission, translation, and historical and geographical interpretation.