bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eye tracking and virtual reality in the rehabilitation of mobility of hemianopia patients: a user experience study
Authors: Gestefeld Birte , Koopman Jan , Vrijling Anne , Cornelissen Frans W. , de Haan Gera 
Published: July 2020

Abstract
Purpose: To test the usability of eye tracking and virtual reality during vision rehabilitation training of hemianopia patients.
Methods: Individuals with hemianopia (n = 13) and normal-sighted controls (n = 4) performed various exercises that are commonly used in vision rehabilitation for mobility, while wearing a head-mounted eye tracker or a head-mounted virtual reality (VR) display. Occupational therapists (n = 4) guided them through the exercises. All participants (including therapists) filled out a questionnaire, assessing their experience with the used device. Individuals with hemianopia were split into three groups according to their stage in vision rehabilitation therapy and performed 1 (beginner), 2 (intermediate) or 3 (advanced) different exercises.
Results: Individuals with hemianopia rated the mobile eye tracker with a score of 3.97 ± 0.5 points (beginner), 3.8 ± 0.5 points (intermediate) and 4 ± 0 points (advanced) the corresponding occupational therapists with a score of 3.6 ± 0.6, 3.4 ± 0.9 and 3.87 ± 0.6 points (out of a maximum of 4 points). The VR headset was rated with 3.9 ± 0.5 points by individuals with hemianopia, 3.8 ± 0.5 points by normal-sighted controls and 2.5 ± 1.4 points by the occupational therapist in a virtual hallway scenario. In a street-crossing scenario, it was rated with 3.7 ± 0.5 points by individuals with hemianopia, 3.7 ± 0.8 points by controls and 2.8 ± 1.2 by occupational therapists. In a walking along a pavement scenario the individual with hemianopia gave 4 ± 0 points and the controls 3.8 ± 0.4 points on average.
Conclusions: Both devices were seen as useful additions to vision rehabilitation therapy, as they enable better feedback to patients and the opportunity to do different exercises at different levels of difficulty.
Application of RUSLE integrated with GIS and remote sensing techniques to assess soil erosion in Anambra State, South-Eastern Nigeria
Authors: Ajibade Fidelis Odedishemi , Nwogwu Nathaniel Azubuike , Adelodun Bashir , Abdulkadir Taofeeq Sholagberu , Ajibade Temitope Fausat , Lasisi Kayode Hassan , Fadugba Olaolu George , Owolabi Titilayo Abimbola , Olajire Olabanji Olatona 
Published: July 2020

Abstract
Soil erosion and mass movement processes spread across Anambra State in Nigeria, therefore making management and conservation techniques expensive and difficult in execution across the entire state. This study employed the Revised Universal Soil Loss Equation (RUSLE) model with the integration of geographic information system (GIS) and remote sensing techniques to assess the risk of soil erosion and hotspots in the area. Remotely sensed data such as Landsat 8 imagery, Shuttle Radar Topography Mission (SRTM) imagery, Era-Interim coupled with world soil database were used as digital data sources for land use map, digital elevation model, rainfall and soil data, respectively, to generate the Universal Soil Loss Equation (USLE) parameters. The results indicated vulnerability levels in low, medium and high cover areas of 4,143.62 (91%), 332.29 (7%) and 84.06 (2%) km2, respectively, with a total soil loss between 0 and 181.237 ton/ha/yr (metric ton per hectare per year). This study revealed that high rainfall erosivity, steep and long slopes, and low vegetation cover were the main factors promoting soil loss in the area. Thus, the amount of soil loss in Anambra State is expected to increase with climate change and anthropogenic activities.
Monitoring point optimization in lake waters
Authors: Liu Gaoxuan , Ai Jiaoyan , Xu Jun , Zheng Jianwu , Yao Dongyi 
Published: July 2020

Abstract
In order to grasp the distribution of water quality index in lake water, taking Jinghu Lake of Guangxi University as the experimental object, an radial basis function (RBF) neural network was combined with a genetic algorithm on the basis of an unmanned ship to study the optimal selection of monitoring points. The single-objective and multi-objective optimization of water quality parameters were tested respectively and used to make the fitting distribution map. The results show that the genetic neural network has obvious advantages over the traditional isometric monitoring in the distribution error of water quality parameters, and the data reflected by the results are still accurate and effective at least six weeks after optimization. The results show that a genetic neural network can significantly improve the efficiency of water quality monitoring.
Correlation Between BCL2 and Mcl1 Single Nucleotide Polymorphisms and Chemotherapy Response in Jordanian Patients with Colorectal Cancer
Authors: Mhaidat Nizar M. , Amawi Haneen , Alzoubi Karem H. 
Published: July 2020

Background:
Colorectal cancer is one of the most common types of cancer worldwide and a
leading cause of death in Jordan. BCL-2 and MCL-1 are anti-apoptotic proteins that inhibit programmed
cell death and their over-expression has been shown to be associated with reduced sensitivity
to chemotherapy and poor survival in cancer patients.

Objective:
In the present study, three SNPs in the promoter region of antiapoptotic genes were investigated
in an effort to inspect the occurrences of SNPs (rs2279115, rs4987852) in the promoter region
of BCL2 and SNP (rs9803935) in the promoter region of MCL1 in Jordanian patients with CRC, and
investigate correlations between BCL2 and MCL1 SNPs and clinical outcomes.

Methods:
PCR-restriction fragment length polymorphism (RFLP)-based analysis was used for samples
genotyping.

Results:
The BCL2 rs2279115 and MCL1 rs9803935 SNPs showed significant distribution where mutant
and hetero genotypes are more prominent in CRC patients. Additionally, the rs2279115 genotypes
and alleles were associated with stages of disease, its recurrence and metastasis. The MCL1 rs9803935
genotypes were associated disease metastasis. However, for BCL2 rs4987852 SNP, there was no association
of genotypes or alleles with any of the disease variables.

Conclusion:
The BCL2 SNPs (rs2279115) and MCL1 SNP (rs9803935) present as important determinants
of the progress of CRC in Jordanian patients.
Long Term Prognostic Utility of Matrix Metalloproteinase-9 in Patients with Acute Coronary Syndrome - A Systematic Review
Authors: Das Anamika , George Melvin , Jha Durga , Goenka Luxitaa 
Published: July 2020

Background:
Acute Coronary Syndrome (ACS) is the leading cause of morbidity and mortality
in developed countries. Numerous groups have explored single and multiple biomarker strategies
to identify diagnostic prognosticators of ACS, which will improve our ability to identify high-risk individuals.
Matrix Metalloproteinase (MMP-9) is one potential biomarker, which has been widely studied
in ACS. Recent reports have showed the prognostic utility of MMP-9, but due to inconsistent results,
it has not been possible to draw firm conclusions.

Objective:
This review aims to explore the ability of MMP-9 to predict long-term prognosis of ACS. To clarify this issue,
we conducted a literature review to provide a comprehensive assessment of MMP-9 levels in ACS patients.

Method:
We retrieved a total of 1501 articles from PubMed and Google Scholar. After thorough scrutiny, 12 original research articles were found fulfilling the inclusion exclusion criteria. MMP-9’s ability as a biomarker of prognostication post
ACS was reviewed. PRISMA guidelines were used for reporting.

Result:
The results revealed that MMP-9, apart from being an efficient diagnostic biomarker for ACS, helps in predicting
the future risk of ACS with disease outcome. Positive correlation was found between plasma MMP-9 and left ventricular
remodeling. A positive association was also found between cardiovascular death and higher MMP-9 levels.

Conclusion:
MMP-9 can be a potential prognostic marker for ACS and aid in identifying high risk patients for intensive
management during follow -up.
Cosmetic Fat Transplantation: A Review
Authors: Davis Sarah , Rizk Joseph , Gunton Jenny E. 
Published: July 2020

Aim:
To review current techniques used in fat grafting to optimise graft
persistence and achieve optimal cosmetic outcomes.

Background:
Fat transplantation has been used extensively in the reconstruction and
cosmetic industry for many years. However, there is significant adipocyte loss and
reabsorption rates, leading to the loss of external cosmetic volume and the need for
repeat procedures. Adipocyte loss can occur at all four stages of transplantation and this
review discusses each of these methods with the aim being to optimise graft outcome.

Results:
Several new techniques have been discussed including liposuction techniques,
fat processing, and assisted fat grafting which show an improvement in adipocyte
survival, revasculisation and graft outcomes.

Conclusions:
There have been many improvements in fat grafting and the
implementation of these will optimise surgical outcomes but there are still strategies to
improve further. However, there is still a lack of standardised techniques and training.
More research is needed in the areas of fat processing and the use of additives to the fat
graft. More clinical research is needed in the fat placement technique, which has very
little published evidence and current techniques are mostly anecdotal by cosmetic
surgeons.
Synthesis and Molecular Simulation Studies of Mandelic Acid Peptidomimetic Derivatives as Aminopeptidase N Inhibitors
Authors: Chen Jiawei , Lv Qiaoli , Tu Guogang 
Published: July 2020

Background:
The aminopeptidase N (APN) over-expressed in tumor cells plays a critical
role in angiogenesis which makes the development of APN inhibitors an attractive strategy for
cancer research.

Aims and Objectives:
It is clinically significant to develop potential APN inhibitors for cancer
treatment. The design, synthesis, biological evaluation and molecular simulation of mandelic acid
peptidomimetic derivatives as APN inhibitors are reported.

Materials and Methods:
Analysis of the binding mode of bestatin to APN led to the design and
synthesis of mandelic acid peptidomimetic derivatives. APN inhibitory activities in vitro were
evaluated by the spectrophotometric method. The binding mode of the target compounds with the
APN binding site was studied relying on docking studies, molecular dynamics simulation experiments
and binding energies calculation.

Results:
The structures of target compounds were confirmed by IR, 1H-NMR and MS. All compounds
exhibited a different range of inhibitory ability with IC50 values lying in the micromolar
level. The compound 9m was found to be most potent as compared to other target derivatives. The
molecular simulation revealed that ligand coordinating with the catalytic zinc ion is very important
for inhibitory activities.

Conclusion:
The compound 9m might represent a promising scaffold for the further development
of novel anti-cancer drugs.
Screening of Drug Efficacy of Rosmarinic Acid Derivatives as Aurora Kinase Inhibitors by Computer-Aided Drug Design Method
Authors: Sarkar Kaushik , Sarkar Subhajit , Das Rajesh Kumar 
Published: July 2020

Background:
Aurora kinases (AKs) belong to serine/threonine kinase family, play a crucial role in regulating the
cell cycle. Therefore, AKs are the hopeful target for anticancer therapies and these finding have appreciated researchers to
rigorous hunting of small molecule aurora kinase inhibitors, not only for research articles but also use as therapeutic agent.

Objective:
The present study helps us to identify and screen best phytochemicals as potent inhibitors against AKs. These
potent inhibitors are coming from various substitution of rosmarinic acid (RA).

Methods:
In this paper, we choose different tested derivative compounds for designing anticancer
drugs by substituting various functional groups of standard drug RA. In silico studies were carried
out to appreciate better drug candidature of some of these derivative compounds. This study was
performed on 56 derived compounds of the standard RA. DFT study was conducted using the
UB3LYP/6-311++G(d,p) basis set to study HOMO-LUMO energies, dipole moments, using the
Gaussian16 suite. Some of the derived parameters, like ionization potential, electron affinity, softness-
hardness, chemical potential, and electrophilicity index were noted. A docking study was performed
with AKs inhibiting receptor using AutoDock 4.2. ADME prediction was made with the
preADMET web tool. Molecular descriptor properties were predicted with molinspiration and
OSIRIS property explorer.

Results:
Out of 56 derivatives, 11 have passed all the rules of drug candidature, to serve as best AKs inhibitor, in a theoretical
manner.

Conclusions:
This study should be supported a new proposal to explore future studies with these 11 compounds against cancer.
The Impact of Opioid Analgesics and the Pharmacogenomics of ABCB1 in Opioid Dependence and Pharmacotherapies: A Short Review
Authors: Parchure Akshay S. , Peng Yuan B. 
Published: July 2020

Pain is extremely multifaceted in nature, with physical injury being just one of its causes. The most commonly prescribed therapeutic intervention for acute as well as chronic pain (postoperative or otherwise) is Opioids. Opioid analgesics act via the opioid receptors (G protein coupled), that are widely distributed in the central and peripheral nervous system as well as the gastrointestinal tract, producing pain relief. The opioid analgesics are divided into distinct categories depending on the receptor type and their potency. Three major types of receptors mediate analgesic effects, namely, mu (μ), delta (δ) and kappa (κ). These are also further subdivided into different subtypes depending on the duration and onset as rapid-onset, short-acting and long-acting. The neurobiology behind opioid analgesia involves the mesolimbic (midbrain) reward system. There is also increasing scientific evidence that plasma pharmacokinetics, along with the CNS distribution of opioids, is greatly influenced by the P-glycoprotein (P-gp) efflux transporter. The ABCB1 gene is responsible for coding P-gp hence it was postulated that variability in the ABCB1 gene could potentially play an important role in determining why there is interindividual variability towards opioids therapeutic interventions
Hence the primary purpose of this review was to compile and understand the research regarding the mechanisms of opioid actions and the effect of genetic variability (ABCB1 gene), on the P-gp transporters regarding their expression/function while also examining the opioid use, abuse and dependence and possibly coming up with some strategies to use pharmacogenomics as a potential tool for solving these issues
Caracterización morfoagronómica de la colección de germoplasma de ají dulce (Capsicum spp.) del caribe colombiano
Authors: Correa-Álvarez Ender M. , León-Pacheco Rommel I. , Lobato-Ureche Miguel A. , García-Davila Mario A. , Muñoz-Perea Carlos G. , Aramendiz-Tatis Hermes 
Published: July 2020

El ají dulce tipo topito es considerado una las principales hortalizas en la región Caribe de Colombia debido a su tradición productiva y consumo cotidiano en al menos seis de los siete departamentos de la costa atlántica. En este sentido el desarrollo de líneas investigación en mejoramiento genético que conduzcan a la obtención de cultivares de mayor productividad cobran gran relevancia. Por ello, con el fin de determinar la variabilidad morfológica y agronómica de la colección de germoplasma de ají dulce del Caribe colombiano y utilizarla en programas de mejoramiento genético, se evaluaron 45 descriptores (cualitativos y cuantitativos) de Capsicum spp. en 125 accesiones procedentes de los siete departamentos de la región Caribe de colombia. Para ello, se empleó un diseño completamente al azar en nueve plantas. El análisis de los datos se realizó a través del método de clasificación de Ward utilizando la distancia de Gower. Los resultados revelan polimorfismo en 19 características cualitativas, con una variabilidad del 67,9%. El análisis mixto de los datos permitió separar las especies del género Capsicum de la colección en estudio; así mismo, la variabilidad fenotípica de la colección muestra potencial para su uso en programas de fitomejoramiento genético en caracteres de interés como calidad de fruto, arquitectura de planta y producción.
Democratização da Administração Pública e os perigos do fascismo no Brasil
Authors: Monteiro Mariano Cynara 
Published: July 2020

<p>O artigo versa sobre um fenômeno muito presente na América latina de retorno cíclico de políticas de austeridade fiscal e de autoritarismo em todas as esferas da vida política e econômica, sempre que, paradoxamente, a Administração pública caminha por uma maior ampliação das políticas públicas visando a inclusão e a democratização econômica e social. Esse fenômeno, em que pese não ser particularidade brasileira, assume uma especificidade no contexto latino americano por sua natureza estrutural, o que torna os movimentos de democratização redundantes no retorno do que Florestan Fernandes chama de fascismo, impedindo a emancipação econômica, política e cultural da América latina. </p>
PENGARUH PELATIHAN, DUKUNGAN MANAJEMEN PUNCAK DAN KEJELASAN TUJUAN TERHADAP EFEKTIVITAS SISTEM AKUNTANSI KEUANGAN DAERAH (Studi Empiris Pada Pemerintah Kabupaten Badung)
Authors: Dewi Cok Istri Ratna Sari , Surya Luh Putu Lusi Setyandarini , Yudha Cokorda Krisna 
Published: July 2020

Abstrcat
This study aims to determine the effect of training, top management support and clarity of objectives on the effectiveness of the Regional Financial Accounting System (SAKD) in Regional Implementing Organizations (OPD) in the Government of Badung Regency. A successful implementation of the system is not only determined by mere technical mastery, the behavioral factors of individual system users can also determine the success of implementation. Training factors, top management support and clarity of objectives are needed to increase the effectiveness of the Regional Financial Accounting System (SAKD) in an organization to support the application of the system in meeting the demands of the public regarding transparency and accountability of public sector institutions. This study uses 132 civil servants who have a main duty to manage finances in the OPD at the Badung Regency Government as a research sample. Determination of the sample in this study using simple random sampling technique. The analysis technique used is multiple linear regression analysis. The results of the study found that training, top management support and clarity of objectives on the Regional Implementing Organization (OPD) in the Badung Regency Government had a positive effect on the effectiveness of the Regional Financial Accounting System (SAKD).
Keywords: Clarity of purpose; effectiveness of the regional financial accounting system; top management support; training

Abstrak
Penelitian ini bertujuan untuk mengetahui pengaruh pelatihan, dukungan manajemen puncak dan kejelasan tujuan terhadap efektivitas Sistem Akuntansi Keuangan Daerah (SAKD) pada Organisasi Pelaksana Daerah (OPD) di Pemerintah Kabupaten Badung. Suatu keberhasilan implementasi sistem tidak hanya ditentukan pada penguasaan teknis belaka, faktor perilaku dari individu pengguna sistem juga dapat menentukan kesuksesan implementasi. Faktor pelatihan, dukungan manajemen puncak dan kejelasan tujuan diperlukan untuk meningkatkan efektivitas Sistem Akuntansi Keuangan Daerah (SAKD) dalam suatu organisasi untuk mendukung penerapan sistem tersebut dalam memenuhi tuntutan masyarakat tentang transparasi dan akuntabilitas lembaga sektor publik. Penelitian ini menggunakan 132 pegawai negeri sipil yang memiliki tupoksi untuk mengelola keuangan di OPD pada Pemerintah Kabupaten Badung sebagai sampel penelitian. Penentuan sampel dalam penelitian ini menggunakan teknik simple random sampling. Teknik analisis yang digunakan adalah analisis regresi linier berganda. Hasil penelitian menemukan bahwa pelatihan, dukungan manajemen puncak dan kejelasan tujuan pada Organisasi Pelaksana Daerah (OPD) di Pemerintah Kabupaten Badung berpengaruh positif terhadap terhadap efektivitas Sistem Akuntansi Keuangan Daerah (SAKD).
Kata Kunci: Kejelasan tujuan; efektivitas sistem akuntansi keuangan daerah; dukungan manajemen puncak; pelatihan
Influence of Renin-Angiotensin System Inhibitors on Lower–Respiratory Tract Infections in Type 2 Diabetes: The Fremantle Diabetes Study Phase II
Authors: Davis Timothy M.E. , Davis Wendy A. 
Published: July 2020

OBJECTIVE
To determine whether ACE inhibitors (ACEi) and angiotensin receptor blockers (ARB) protect against lower–respiratory tract infections complicating type 2 diabetes.

RESEARCH DESIGN AND METHODS
Of 1,732 participants with diabetes recruited to the longitudinal observational Fremantle Diabetes Study Phase II (FDS2) between 2008 and 2011, 1,482 had confirmed type 2 diabetes (mean age 65.8 years and median diabetes duration 9.0 years; 51.6% were male). All were followed for hospitalizations for or with, or deaths from, pneumonia/influenza, ascertained from validated administrative data linkage from study entry to end of 2016. Cox regression and competing risk regression were used to identify independent predictors of this outcome.

RESULTS
Two-thirds of participants (n = 982) were taking an ACEi and/or ARB at study entry (498 [33.6%] ACEi, 408 [27.5%] ARB, 76 [5.1%] both). During 9,511 person-years of follow-up (mean ± SD 6.4 ± 2.0 years), 174 participants had incident pneumonia/influenza (156 hospitalizations and 18 deaths without hospitalization). In Cox regression analysis, baseline ACEi/ARB use was independently associated with a reduced risk of incident pneumonia/influenza (cause-specific hazard ratio [HR] 0.64 [95% CI 0.45, 0.89], P = 0.008). Allowing for the competing risk of death did not change this finding (subdistribution HR 0.67 [0.48, 0.95], P = 0.024), and similar reductions were seen for ACEi, ARB alone, and ACEi/ARB combination therapy. There was no significant change in use of ACEi/ARB during follow-up [interaction with ln(time), P = 0.70]. Other significant predictors of incident pneumonia/influenza were previously reported, clinically plausible variables.

CONCLUSIONS
ACEi/ARB reduce the risk of pneumonia/influenza in people with type 2 diabetes.
Pertanggungjawaban Pidana Partai Politik dalam Tindak Pidana Korupsi
Authors: Setyawan Vincentius patria 
Published: July 2020

ABSTRAKPenelitian ini bertujuan untuk mengetahui pengaturan mengenai pertanggungjawaban pidana korporasi bagi partai politik dalam hal terjadinya tindak pidana korupsi, dan formulasi pertanggungjawaban pidana tersebut serta bentuk sanksi yang akan dijatuhkan kepada partai politik selaku korporasi. Hasil dari penelitian ini adalah rekomendasi untuk penerapan pertanggungjawaban pidana koporasi bagi partai politik dan jenis-jenis sanksi yang dapat diterapkan kepada partai politik selaku korporasiKata Kunci: partai politik, pertanggungjawaban pidana. korporasi ABSTRACTThis study aims to determine the arrangements regarding corporate criminal liability for political parties in the event of criminal acts of corruption, and the formulation of these criminal liabilities and the form of sanctions to be imposed on political parties as corporations. The results of this study are recommendations for the application of corporate criminal liability for political parties and types of sanctions that can be applied to political parties as corporationsKeywords: political parties, criminal liability. corporation