bluuebunny/crossref_metadata_2025_split huggingface dataset:
A ergonomia cognitiva aplicada a interfaces de máquina de lavar: uma proposta de redesign inclusivo | Ergonomics applied to washing machine interfaces: an inclusive redesign proposal focused on the elderly
Authors: Kumagai Deborah Naomi , Tomazzia Pâmela Greice , De Medeiros Ivan Luiz 
Published: December 2020

O envelhecimento populacional, um efeito da transição demográfica acelerada no Brasil, evidencia a necessidade de projetar para atender as demandas deste segmento da população que, embora compreenda um extremo etário, mantêm-se ativo, com autonomia nas atividades cotidianas. Deste modo, o presente estudo teve como propósito a problematização, sob a ótica da ergonomia cognitiva, dos padrões de interface nos modelos de máquinas de lavar residenciais disponíveis no mercado, e a apresentação de uma proposta de um redesign alinhado aos princípios do Design Universal para, assim, proporcionar melhores experiências de uso, de forma inclusiva e sem estigmatização de qualquer segmento do público usuário. *****The population ageing, an effect of the accelerated demographic transition in Brazil, highlights the necessity of designing to fulfill the demands from this population segment, which, despite comprising the senior age range, stays active and maintains its autonomy in day-to-day activities. Thus, this study had the intent of discussing, from the perspective of ergonomics, the interface design standards in residential washing machine models available on the Brazilian market, in order to present a redesign proposal envisioning better experiences for elderly users.
TUBERCULOSE BOVINA EM PROPRIEDADE RURAL NO MUNICÍPIO DE SEROPÉDICA, RIO DE JANEIRO, BRASIL: RELATO DE CASO
Authors: Da Silva Lília Aparecida Marques , De Freitas Marina Sereno , Cicarino Julio Cesar Da Silva , De Almeida Jaci 
Published: December 2020

A tuberculose é uma das principais doenças infecciosas de importância econômica em bovídeos, podendo acometer outras espécies de animais e inclusive o homem, causando perdas econômicas ao setor de produção, além de ocasionar agravos à saúde pública. É uma zoonose de notificação obrigatória que no Brasil possui um programa de controle e erradicação instituído pelo Ministério da Agricultura, Pecuária e Abastecimento (MAPA), o Programa Nacional de Controle e Erradicação da Brucelose e Tuberculose (PNCEBT) dos bovídeos, que tem por objetivo principal a redução da prevalência e da incidência da brucelose e tuberculose nessas espécies. O Núcleo de Defesa Agropecuária (NDA) do Rio de Janeiro da Secretaria de Estado de Agricultura, Pecuária, Pesca e Abastecimento (SEAPPA) do Rio de Janeiro é responsável pelas ações de vigilância veterinária oficial no município de Seropédica. O presente trabalho tem por objetivo relatar a ocorrência de um foco de tuberculose no município de Seropédica e as ações executadas pelo serviço de vigilância oficial da SEAPPA. No ano de 2020, os técnicos do NDA Rio de Janeiro receberam o informe de notificação com laudo laboratorial positivo para tuberculose, pela técnica de histoquímica em seções de pulmão e encéfalo, de uma fêmea bovina da raça Girolando, com aproximadamente seis anos, necropsiada numa propriedade rural localizada no município de Seropédica. Após a notificação, o serviço oficial realizou a vistoria da propriedade e solicitou ao produtor que realizasse a tuberculinização nos demais animais conforme prevê o regulamento do PNCEBT. Houve a notificação imediata às Secretarias Municipais de Saúde e Agricultura domunicípio de Seropédica para as providências junto ao produtor e demais envolvidos, haja vista que as medidas com relação aos animais na propriedade já haviam sido executadas pelo serviço oficial de modo a debelar o foco. Com a apresentação do atestado de exames negativos ao teste de tuberculinização comparativo simples dos demais bovinos do plantel, foi encerrado o foco napropriedade. Conclui-se que a tuberculose bovina está presente no estado do Rio de Janeiro, e que necessita da conscientização tanto por parte dos médicos veterinários quanto dos produtores para maior adesão do PNCEBT, controlando assim a enfermidade nos rebanhos. Há a necessidade da realização de um estudo epidemiológico para conhecimento da prevalência da tuberculose no estado por se tratar de uma questão de saúde pública, uma vez que os testes de tuberculinização são obrigatórios apenas para fins de trânsito para as finalidades reprodução e participação em eventos agropecuários, existindo vários criatórios que não realizam exames e assim, outros focos podem existir devido à prática da troca de animais principalmente entre os pequenos produtores.
MEGAESÔFAGO SECUNDÁRIO A PERSISTÊNCIA DO ARCO AÓRTICO DIREITO EM CÃO DA RAÇA PASTOR ALEMÃO – RELATO DE CASO
Authors: Meira Júlia , Garcia Cinthia , Borges Isadora Scherer , Dos Reis Lucas Dornelles , Lopes Wesley Renosto 
Published: December 2020

RESUMO: O megaesôfago é um transtorno relacionado a dilatação e hipomotilidade esofágica e é considerado a principal causa de regurgitação em cães. Pode ocorrer de forma primária ou secundária, classificado em congênito, adquirido idiopático e adquirido secundário. A forma secundária adquirida pode ocorrer em inúmeras circunstâncias, e dentre elas evidencia-se as anomalias de anel vascular, como a persistência do arco aórtico direito (KOZU et al., 2015). Estas anomalias são malformações congênitas dos principais vasos da base do coração, os quais, por estarem em posições errôneas, comprimem o esôfago ou a traqueia, acarretando obstrução física desses órgãos e ocasionando afecções digestivas ou respiratórias (MENZEL; DISTL, 2011). O objetivo deste resumo é descrever o caso de um cão, macho, com quatro meses de idade que foi atendido na Clínica Ducão Veterinária, Caxias do Sul/RS, pesando 8,6 kg, da raça Pastor Alemão com histórico de êmese recorrente. Ao exame físico do paciente foi observado baixo escore corporal, 5 em uma escala de 0-10, retardo no crescimento e desidratação de 3%. Mucosas apresentavam-se normocoradas, tempo de perfusão capilar de dois segundos, linfonodos não reativos, frequência cardíaca, frequência respiratória e temperatura retal dentro dos parâmetros fisiológicos da espécie. Foi solicitado hemograma e exame radiográfico simples e contrastado de região cérvico-torácica. No exame hematológico constatou-se em aumento nos valores de eritrócitos, hematócrito, hemoglobina e diminuição de proteínas totais caracterizando assim, uma policitemia relativa devido ao estado de desidratação e hipoproteinemia por desnutrição. No exame radiográfico simples foi observado lúmen traqueal deslocado cranialmente em sua porção torácica e perda da conformação normal da silhueta cardíaca, sugerindo anomalia por aneladura vascular e na radiografia contrastada, observou-se esôfago dilatado cranialmente a base do coração, levando ao diagnóstico de megaesofâgo. Desta forma, foi indicado oferecer alimentação pastosa de forma elevada, aproximadamente 45 cm do chão. O tratamento clínico é realizado, mas o procedimento cirúrgico é preconizado por haver uma melhora significativa dos sinais clínicos (MENZEL; DISTL, 2011). O paciente aqui relatado demonstrou melhoras após a mudança no manejo alimentar, porém não de forma satisfatória, sendo encaminhado precocemente para a correção cirúrgica através da secção do ducto arterioso, garantindo um prognóstico satisfatório.
LA PROTECCIÓN DE LAS PAREJAS HOMOSEXUALES FRENTE A LA DISCRIMINACIÓN EN LA EVOLUCIÓN DE LA JURISPRUDENCIA DEL TRIBUNAL EUROPEO: PASADO, PRESENTE Y UNAS PREVISIONES PARA EL FUTURO
Authors: Romboli Silvia 
Published: December 2020

El artículo pretende presentar, en ocasión del sesenta aniversario de la puesta en marcha del TEDH, un atento estudio de la jurisprudencia del Tribunal de Estrasburgo en materia de protección de las personas y de las parejas homosexuales frente a la discriminación por orientación sexual, proporcionando algunas consideraciones críticas sobre la aplicación del art. 14 CEDH en este ámbito y sobre los posibles escenarios futuros. El propósito de la investigación es comprobar las efectivas aportaciones del TEDH en la configuración de un espacio europeo de protección de los derechos y, en particular, si, después de varias décadas, el Consejo de Europa ha realmente creado las bases para una concreta y sustancial igualdad entre personas y parejas heterosexuales y homosexuales.
The aim of the article is to present, on the occasion of the 60th anniversary of the ECtHR, an attentive study of the jurisprudence of the Court of Strasbourg on the protection of homosexual persons and couples against discrimination based on sexual orientation, providing some critical considerations on the application of art. 14 ECHR in this area and on possible future scenarios. The purpose of the research is to verify the effective contributions of the ECtHR in shaping a European area of protection of rights and, in particular, if, after several decades, the Council of Europe has really created the basis for a concrete and substantial equality between heterosexual and homosexual persons and couples.
Hamsuns <i>I Æventyrland</i> sett i et «grenselandsperspektiv»
Authors: Loria Kakhaber 
Published: December 2020

At Hamsun er opptatt av grensetematikk, er vel kjent. Han krysser, bryter, oppløser eller trekker opp nye grenser, både geografisk, sjangermessig og biografisk. Hamsuns I Æventyrland. Oplevet og drømt i Kaukasien (1903) er karakteristisk i så måte. Verket beskriver reisen gjennom Russland og Kaukasus, men samtidig følger vi også en reise inn i fortellerens indre natur. I boken finnes ingen reell grense mellom virkelighet og fantasi. Alt er blandet sammen med hamsunsk estetisk kløkt. Grenseperspektivet manifesterer seg i boken på en rekke nivåer. Geografisk, fordi han krysser Store Kaukasus, dernest hans utvisking av grensen mellom drøm og virkelighet i fremstillingen av seg selv som bokens jeg-person, mm.
På Hamsuns tid var Sørkaukasus en del av Det russiske imperium og delt i guvernementer. Tbilisi var administrasjonssenter for hele Kaukasus og sete for tsarens stattholder. Guvernementsgrensene eksisterer ikke for Hamsun. Han trekker opp sine egne grenser mellom det han opplever som orientalsk og det han opplever som vestlig, både topografisk, religiøst og kulturelt. Han viser en åpenbar forkjærlighet for alt ikke-vestlig og ikke-kristent. Slik skaper han så å si sin egen «Orientalisme» i boken.
Determination of pKa and Degradation Products of the Mutated BRAF Inhibitor Vemurafenib and UPLC Assay in Human Urine
Authors: Şanli Senem , Özdemir Ayşe , Güven Gülşen , Gökçe Süleyman 
Published: December 2020

In this study, the pKa value of vemurafenib was determined by the dependence of the retention factor on the pH of the mobile phase. The change of pKa in the different acetonitrile fraction ranging between 57.5 and 62.5% (v/v) was studied by using an LC-UV method. Additionally, a simple, reliable, and rapid UPLC method has been developed for the determination of vemurafenib in human urine. Efavirenz was used as an internal standart. For vemurafenib and efavirenz, selectivity factors were found as 1.204. The asymmetry and capacity factors were obtained as 1.100 and 7.532 for vemurafenib.
Vemurafenib was exposed to thermal, photolytic, hydrolytic, and oxidative stress conditions, and the stressed samples were detected by LC/MS/MS method.
Actigraphic sleep patterns and cognitive decline in the Hispanic Community Health Study/Study of Latinos
Authors: Agudelo Christian , Tarraf Wassim , Wu Benson , Wallace Douglas M. , Patel Sanjay R. , Redline Susan , Kaur Sonya , Daviglus Martha , Zee Phyllis C. , Simonelli Guido , Mossavar‐Rahmani Yasmin , Sotres‐Alvarez Daniela , Zeng Donglin , Gallo Linda C. , González Hector M , Ramos Alberto R. 
Published: December 2020

AbstractIntroductionWe determined if actigraphy‐derived sleep patterns led to 7‐year cognitive decline in middle‐aged to older Hispanic/Latino adults.MethodsWe examined 1035 adults, 45 to 64 years of age, from the Hispanic Community Health Study/Study of Latinos. Participants had repeated measures of cognitive function 7 years apart, home sleep apnea studies, and 1 week of actigraphy. Survey linear regression evaluated prospective associations between sleep and cognitive change, adjusting for main covariates.ResultsLonger sleep‐onset latency was associated with declines in global cognitive function, verbal learning, and verbal memory. Longer sleep‐onset latency was also cross‐sectionally associated with verbal learning, verbal memory, and word fluency. Sleep fragmentation was not associated with cognitive change.ConclusionIn a cohort of mostly middle‐aged Hispanic/Latinos, actigraphy‐derived sleep‐onset latency predicted 7‐year cognitive change. These findings may serve as targets for sleep interventions of cognitive decline.
Statistical method for modeling sequencing data from different technologies in longitudinal studies with application to Huntington disease
Authors: Fuady Angga M. , van Roon‐Mom Willeke M. C. , Kiełbasa Szymon M. , Uh Hae‐Won , Houwing‐Duistermaat Jeanine J. 
Published: December 2020

AbstractAdvancement of gene expression measurements in longitudinal studies enables the identification of genes associated with disease severity over time. However, problems arise when the technology used to measure gene expression differs between time points. Observed differences between the results obtained at different time points can be caused by technical differences. Modeling the two measurements jointly over time might provide insight into the causes of these different results. Our work is motivated by a study of gene expression data of blood samples from Huntington disease patients, which were obtained using two different sequencing technologies. At time point 1, DeepSAGE technology was used to measure the gene expression, with a subsample also measured using RNA‐Seq technology. At time point 2, all samples were measured using RNA‐Seq technology. Significant associations between gene expression measured by DeepSAGE and disease severity using data from the first time point could not be replicated by the RNA‐Seq data from the second time point. We modeled the relationship between the two sequencing technologies using the data from the overlapping samples. We used linear mixed models with either DeepSAGE or RNA‐Seq measurements as the dependent variable and disease severity as the independent variable. In conclusion, (1) for one out of 14 genes, the initial significant result could be replicated with both technologies using data from both time points; (2) statistical efficiency is lost due to disagreement between the two technologies, measurement error when predicting gene expressions, and the need to include additional parameters to account for possible differences.
Low molecular weight fucoidan inhibits hepatocarcinogenesis and nonalcoholic fatty liver disease in zebrafish via ASGR/STAT3/HNF4A signaling
Authors: Wu Szu‐Yuan , Yang Wan‐Yu , Cheng Chun‐Chia , Lin Kuan‐Hao , Sampurna Bonifasius Putera , Chan Suat‐Ming , Yuh Chiou‐Hwa 
Published: December 2020

AbstractBackgroundHepatocellular carcinoma ranks fourth in cancer‐related mortality currently lacks effective therapeutics. Fucoidan is sulfated polysaccharide that is mainly found in brown seaweeds. In this study, we investigated the effects and mechanisms of low molecular weight fucoidan (i.e. oligo‐fucoidan [OF]) preventing hepatocarcinogenesis.MethodsWe used [HBx,src], [HBx,src,p53−/+], and [CD36] transgenic zebrafish liver cancer model treated with OF, and performed molecular and histopathological analysis. Transcriptomic and pathways analysis was performed.ResultsDecreased expression of lipogenic enzymes, fibrosis markers, and cell cycle/proliferation markers by OF in [HBx,src] and [HBx,src,p53−/+] transgenic fish. Liver fibrosis was decreased as revealed by Sirius Red staining, and the liver cancer formation was eventually reduced by feeding OF. OF was also found to be capable of reducing lipid accumulation and cancer formation in non‐B non‐C Hepatocellular carcinoma (HCC) model in CD36 transgenic zebrafish. Whole‐genome expression analysis showed that 661 genes were up‐regulated, and 451 genes were downregulated by feeding OF. Upregulated genes were mostly found in protein transporter activity, and downregulated genes were enriched with response to extracellular stimulus and metal binding in gene ontology analysis. The driver gene was HNF4A revealed by NetworkAnalyst from OF differential regulated genes at various insults. OF is able to bind the asialoglycoprotein receptor (ASGR) in hepatoma cells, and increased the phosphorylation of signal transducer and activator of transcription 3 (STAT3) in both hepatoma cells and [HBx,src,p53−/+] transgenic fish liver cancer model. Using chromatin‐immunoprecipitation, we found pSTAT3 could associate with the P1 promoter of HNF4A. Knockdown of either ASGR or HNF4A reversed OF mediated anti‐cancer cell proliferation.ConclusionsTaken together, we provide evidence that OF exhibits the anti‐HCC, anti‐steatosis, and anti‐fibrosis effect for liver in zebrafish models, and the anti‐cancer potential of OF attributed to the binding to ASGR and activation of STAT3/HNF4A signaling. OF might be potentially valuable for the management of HCC.
Corpora amylacea in pleural effusion
Authors: Mani Haresh , Wang Brant G. 
Published: December 2020

AbstractCorpora amylacea are predominantly found in the brain, prostate, and lung. Recent characterizations of their components suggest an important role in protection and clearing. We report the presence of corpora amylacea in pleural effusion in a patient with lupus. The differential diagnoses and potential significance are discussed.
The phylogeny, phylogeography, and diversification history of the westernmost Asian cobra (Serpentes: Elapidae: Naja oxiana) in the Trans‐Caspian region
Authors: Kazemi Elmira , Nazarizadeh Masoud , Fatemizadeh Faezeh , Khani Ali , Kaboli Mohammad 
Published: December 2020

AbstractWe conducted a comprehensive analysis of the phylogenetic, phylogeographic, and demographic relationships of Caspian cobra (Naja oxiana; Eichwald, 1831) populations based on a concatenated dataset of two mtDNA genes (cyt b and ND4) across the species' range in Iran, Afghanistan, and Turkmenistan, along with other members of Asian cobras (i.e., subgenus Naja Laurenti, 1768). Our results robustly supported that the Asiatic Naja are monophyletic, as previously suggested by other studies. Furthermore, N. kaouthia and N. sagittifera were recovered as sister taxa to each other, and in turn sister clades to N. oxiana. Our results also highlighted the existence of a single major evolutionary lineage for populations of N. oxiana in the Trans‐Caspian region, suggesting a rapid expansion of this cobra from eastern to western Asia, coupled with a rapid range expansion from east of Iran toward the northeast. However, across the Iranian range of N. oxiana, subdivision of populations was not supported, and thus, a single evolutionary significant unit is proposed for inclusion in future conservation plans in this region.
Using principal component analysis to explore consumers' perception toward quinoa health and nutritional claims in Gweru, Zimbabwe
Authors: Muziri Tavagwisa , Chaibva Paul , Chofamba Anyway , Madanzi Tendai , Mangeru Pepukai , Mudada Nhamo , Manhokwe Shephard , Mugari Amiel , Matsvange Diego , Murewi Cyril Tapiwa Farai , Mwadzingeni Liboster , Mugandani Raymond 
Published: December 2020

AbstractQuinoa is one of the ancestral grains now considered as the “superfoods of the future” due to their characteristics as functional foods with great environmental adaptability. The Zimbabwe Resilience Building Fund has introduced quinoa in Zimbabwe to increase resilience of farming systems in light of environmental shocks. In order to improve adoption of the crop, it is important to understand the combined effects of socio‐demographic variables on consumer perceptions of the crop. However, there is limited literature on the combined effects of socio‐demographic variables on quinoa health and nutritional benefits in Zimbabwe. In this study, we used principle component analysis to identify consumers' perception about health and nutritional benefits of quinoa in Gweru Urban District, Gweru, Zimbabwe. A questionnaire was designed and applied to 200 participants. However, only 167 forms were valid for analysis. Age, education, and income level are main factors that determine consumer perceptions on health and nutritional claims. The results indicate that quinoa need to be promoted a as a crop that goes beyond food and income security by placing additional emphasis on health and nutritional aspects. This is very insightful in light of the need to improve the uptake of the crop by smallholder farmers in Zimbabwe. However, the use of self‐reporting survey method has received criticism for failing to get detailed information on perceptions of individuals. These findings could be handy to promote quinoa as a climate smart crop with additional health and nutritional benefits. This is one of the novel research studies exploring the motives of Zimbabwean consumers towards quinoa as a functional food crop. The work also contributes to knowledge on consumer food preferences.
Sequential attack salvo size is monotonic nondecreasing in both time and inventory level
Authors: Kalyanam Krishna , Clarkson Jake 
Published: December 2020

AbstractAn attacker with homogeneous weapons aims to destroy a target via sequential engagements over a finite planning horizon. Each weapon, with an associated cost, has a nonzero probability of destroying the target. At each decision epoch, the attacker can allocate a salvo of weapons to increase its chances, however this comes at the increasing linear cost of allocating additional weapons. We assume complete information in that the target status (dead or alive) is known. The attacker aims to maximize its chances of destroying the target while also minimizing the allocation cost. We show that the optimal salvo size, which is a function of time and inventory levels, is monotonic nondecreasing in both variables. In particular, we show that the salvo size either stays the same or decreases by one when the inventory level drops by one. The optimal allocation can be computed by solving a nonlinear stochastic dynamic program. Given the computational burden typically associated with solving Bellman recursions, we provide a scalable linear recursion to compute the optimal salvo size and numerical results to support the main ideas.