bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digestive tract microbiota of beef cattle that differed in feed efficiency
Authors: Freetly Harvey C , Dickey Aaron , Lindholm-Perry Amanda K , Thallman Richard M , Keele John W , Foote Andrew P , Wells James E 
Published: January 2020

Abstract
We hypothesized cattle that differed in BW gain had different digestive tract microbiota. Two experiments were conducted. In both experiments, steers received a diet that consisted of 8.0% chopped alfalfa hay, 20% wet distillers grain with solubles, 67.75% dry-rolled corn, and 4.25% vitamin/mineral mix (including monensin) on a dry matter basis. Steers had ad libitum access to feed and water. In experiment 1, 144 steers (age = 310 ± 1.5 d; BW = 503 ± 37.2 kg) were individually fed for 105 d. Ruminal digesta samples were collected from eight steers with the greatest (1.96 ± 0.02 kg/d) and eight steers with the least ADG (1.57 ± 0.02 kg/d) that were within ±0.32 SD of the mean (10.1 ± 0.05 kg/d) dry matter. In experiment 2, 66 steers (age = 396 ± 1 d; BW = 456 ± 5 kg) were individually fed for 84 d. Rumen, duodenum, jejunum, ileum, cecum, and colon digesta samples were collected from eight steers with the greatest (2.39 ± 0.06 kg/d) and eight steers with the least ADG (1.85 ± 0.06 kg/d) that were within ±0.55 SD of the mean dry matter intake (11.9 ± 0.1 kg/d). In both studies, DNA was isolated and the V1 to V3 regions of the 16S rRNA gene were sequenced. Operational taxonomic units were classified using 0.03 dissimilarity and identified using the Greengenes 16S rRNA gene database. In experiment 1, there were no differences in the Chao1, Shannon, Simpson, and InvSimpson diversity indexes or the permutation multivariate analysis of variance (PERMANOVA; P = 0.57). The hierarchical test returned six clades as being differentially abundant between steer classifications (P &lt; 0.05). In experiment 2, Chao1, Shannon, Simpson, and InvSimpson diversity indexes and PERMANOVA between steer classified as less or greater ADG did not differ (P &gt; 0.05) for the rumen, duodenum, ileum, cecum, and colon. In the jejunum, there tended to be a difference in the Chao1 (P = 0.09) and Simpson diversity (P = 0.09) indexes between steer classifications, but there was no difference in the Shannon (P = 0.14) and InvSimpson (P = 0.14) diversity indexes. Classification groups for the jejunum differed (P = 0.006) in the PERMANOVA. The hierarchical dependence false discovery rate procedure returned 11 clades as being differentially abundant between steer classifications in the jejunum (P &lt; 0.05). The majority of the OTU were in the Families Corynebacteriaceae and Coriobacteriaceae. This study suggests that intestinal differences in the microbiota of ruminants may be associated with animal performance.
Herbal Products for Treatment of Burn Wounds
Authors: Herman Anna , Herman Andrzej P 
Published: January 2020

Abstract
The purpose of this review is to summarize the current knowledge acquired during preclinical and clinical studies regarding topically used herbal products with burn wound-healing activity. Moreover, antimicrobial, anti-inflammatory, and antioxidant mechanisms of their action as well as adverse effects of herbal therapy will be also described.
Border effects in European public procurement
Authors: Herz Benedikt , Varela-Irimia Xosé-Luís 
Published: January 2020

Abstract
In this paper, we document border effects in the award of public contracts in the European single market. We use a dataset of 1.8 million contract awards, which we match to geolocations to estimate a gravity model of procurement flows between European NUTS3 region pairs. We find very sizable cross-national border effects for all types of goods and services, even after controlling for physical distance, currency, cultural differences and other variables. For example, ‘local’ bidders for IT services contracts are almost 250 times more likely to be awarded a contract than ‘foreign’ bidders. More surprisingly, we find substantial cross-regional border effects within countries. While we document that firms’ bidding decisions are subject to border effects, we cannot exclude a home bias of contracting authorities in the award of public contracts.
Swedish Patent and Market Court of Appeal clarifies rules on influencer marketing
Authors: Fassihi Rebecca , Zenk Kajsa 
Published: January 2020

Abstract
The Consumer Ombudsman v Alexandra Media Sweden AB and Tourn Media AB, Patent and Market Court of Appeal, PMT 2054-18, 5 December 2019
The Swedish Patent and Market Court of Appeal ruled in favour of the Swedish Consumer Ombudsman, setting out guidelines for how Swedish law shall be interpreted in relation to influencer marketing.
Estrogen/estrogen receptor promotes the proliferation of endometrial carcinoma cells by enhancing hMOF expression
Authors: Qi Yue , Tan Mingzi , Zheng Mingjun , Jin Shan , Wang Huimin , Liu Juanjuan , Wang Peiyao , Nie Xin , Gao Lingling , Lin Bei 
Published: January 2020

AbstractBackgroundThis study aims to analyse the expression of human MOF in endometrial carcinoma cells and its relationship with estrogen and estrogen receptor and to investigate the effect of estrogen–human MOF on the malignant biological behaviours of endometrial carcinoma cells.MethodsThe expression of human MOF was detected in different endometrial tissues by immunohistochemistry. The effects of human MOF, human MOF combined with estrogen stimulation and estrogen plus anti-human MOF antibody blocking on the proliferation of endometrial carcinoma cells were evaluated by western blotting, real-time polymerase chain reaction, cell proliferation assay and cell cycle distribution. Bioinformatics was used to identify the correlations of human MOF and estrogen and involved pathways.ResultsThe expression levels of human MOF in endometrial carcinoma tissues were significantly higher than that in atypical hyperplasia and normal endometrial tissues. High expression of human MOF was associated with late-stage cancer, lymph node metastasis and short survival time, and it was also an independent prognostic risk factor for endometrial carcinoma. After human MOF knockdown, the proliferation, migration and invasive capacity of Ishikawa cells decreased and cell apoptosis increased. After stimulation with estrogen, the PI3K/Akt and Ras–Raf–MEK–ERK signalling pathways were activated, and the expression of the human MOF protein was increased. human MOF (KAT8) expression showed a positive correlation with ESR1 expression, and KAT8-associated genes were enriched in the cell cycle pathways and splicing pathways.ConclusionHuman MOF was highly expressed in endometrial carcinoma and associated with proliferation. Estrogen/estrogen receptor enhanced human MOF expression; promoted the proliferation, migration and invasion of Ishikawa cells; and inhibited cell apoptosis by activating the PI3K/Akt and Ras–Raf–MEK–ERK signalling pathways.
An allelic variant of GAME9 determines its binding capacity with the GAME17 promoter in the regulation of steroidal glycoalkaloid biosynthesis in tomato
Authors: Yu Gang , Li Changxing , Zhang Lei , Zhu Guangtao , Munir Shoaib , Shi Caixue , Zhang Hongyan , Ai Guo , Gao Shenghua , Zhang Yuyang , Yang Changxian , Zhang Junhong , Li Hanxia , Ye Zhibiao 
Published: January 2020

AbstractSteroidal glycoalkaloids (SGAs) are cholesterol-derived molecules found in the family Solanaceae. SGA content varies among different plant species and varieties. However, the genetic mechanisms regulating SGA content remain unclear. Here, we demonstrate that genetic variation in GLYCOALKALOID METABOLISM 9 (GAME9) is responsible for the variation in SGA content in tomato (Solanum lycopersicum). During a sequential analysis we found a 1 bp substitution in the AP2/ERF binding domain of GAME9. The 1 bp substitution in GAME9 was significantly associated with high SGA content and determined the binding capacity of GAME9 with the promoter of GAME17, a core SGA biosynthesis gene. The high-SGA GAME9 allele is mainly present in S. pimpinellifolium and S. lycopersicum var. cerasiforme populations and encodes a protein that can bind the GAME17 promoter. In contrast, the low-SGA GAME9 allele is mainly present in the big-fruited varieties of S. lycopersicum and encodes a protein that shows weak binding to the GAME17 promoter. Our findings provide new insight into the regulation of SGA biosynthesis and the factors that affect the accumulation of SGA in tomato.
Aphid fecundity and defenses in wheat exposed to a combination of heat and drought stress
Authors: Xie Haicui , Shi Jianqin , Shi Fengyu , Xu Haiyun , He Kanglai , Wang Zhenying 
Published: January 2020

AbstractPlants are routinely subjected simultaneously to different abiotic and biotic stresses, such as heat, drought, and insect infestation. Plant–insect interactions in such complex stress situations are poorly understood. We evaluated the performance of the grain aphid (Sitobion avenae) in wheat (Triticum aestivum L.) exposed to a combination of heat and drought stresses. We also performed assays of the relative water content, nutritional quality, and responses of phytohormone signaling pathways. Lower relative water content and accumulation of soluble sugars and amino acids were observed in plants exposed to combined heat and drought stress. These conditions increased abscisic acid levels in the absence of aphids, as well as leading to higher levels of jasmonate-dependent transcripts. The grain aphid infestation further increased abscisic acid levels and the abundance of jasmonic acid- and salicylic acid-dependent defenses under the combined stress conditions. Aphids reared on plants grown under drought stress alone showed lower net reproductive rates, intrinsic rates of increase, and finite rates of increase compared with aphids reared on plants in the absence of stress. The heat-treated plants also showed a decreased aphid net reproductive rate. These findings demonstrate that exposure to a combination of stresses enhances plant defense responses against aphids as well as altering nutritional quality.
The H i morphology and stellar properties of strongly barred galaxies: support for bar quenching in massive spirals
Authors: Newnham L , Hess Kelley M , Masters Karen L , Kruk Sandor , Penny Samantha J , Lingard Tim , Smethurst R J 
Published: January 2020

ABSTRACT
Galactic bars are able to affect the evolution of galaxies by redistributing their gas, possibly contributing to the cessation of star formation. Several recent works point to ‘bar quenching’ playing an important role in massive disc galaxies. We construct a sample of six gas-rich and strongly barred disc galaxies with resolved H i observations. This sample of galaxies, which we call H i-rich barred galaxies, was identified with the help of Galaxy Zoo to find galaxies hosting a strong bar, and the Arecibo Legacy Fast Arecibo L-band Feed Array blind H i survey to identify galaxies with a high H i content. The combination of strong bar and high gas fraction is rare, so this set of six galaxies is the largest sample of its type with resolved H i observations. We measure the gas fractions, H i morphology and kinematics, and use archival optical data from the Sloan Digital Sky Survey to reveal star formation histories and bar properties. The galaxies with the lowest gas fractions (still very high for their mass) show clear H i holes, dynamically advanced bars, and low star formation rates, while those with the highest gas fractions show little impact from their bar on the H i morphology, and are still actively star-forming. These galaxies support a picture in which the movement of gas by bars can lead to star formation quenching. How these unusual galaxies came to be is an open question.
The evolution of rest-frame UV properties, Ly α EWs, and the SFR–stellar mass relation at z ∼ 2–6 for SC4K LAEs
Authors: Santos S , Sobral D , Matthee J , Calhau J , da Cunha E , Ribeiro B , Paulino-Afonso A , Arrabal Haro P , Butterworth J 
Published: January 2020

ABSTRACT
We explore deep rest-frame UV to FIR data in the COSMOS field to measure the individual spectral energy distributions (SED) of the ∼4000 SC4K (Sobral et al.) Lyman α (Ly α) emitters (LAEs) at z ∼ 2–6. We find typical stellar masses of 109.3 ± 0.6 M⊙ and star formation rates (SFR) of SFR$_{\rm SED}=4.4^{+10.5}_{-2.4}$ M⊙ yr−1 and SFR$_{\rm Ly\,\alpha }=5.9^{+6.3}_{-2.6}$ M⊙ yr−1, combined with very blue UV slopes of $\beta =-2.1^{+0.5}_{-0.4}$, but with significant variations within the population. MUV and β are correlated in a similar way to UV-selected sources, but LAEs are consistently bluer. This suggests that LAEs are the youngest and/or most dust-poor subset of the UV-selected population. We also study the Ly α rest-frame equivalent width (EW0) and find 45 ‘extreme’ LAEs with EW0 &gt; 240 Å (3σ), implying a low number density of (7 ± 1) × 10−7 Mpc−3. Overall, we measure little to no evolution of the Ly α EW0 and scale length parameter (w0), which are consistently high (EW$_0=140^{+280}_{-70}$ Å, $w_0=129^{+11}_{-11}$ Å) from z ∼ 6 to z ∼ 2 and below. However, w0 is anticorrelated with MUV and stellar mass. Our results imply that sources selected as LAEs have a high Ly α escape fraction (fesc,Ly α) irrespective of cosmic time, but fesc,Ly α is still higher for UV-fainter and lower mass LAEs. The least massive LAEs (&lt;109.5 M⊙) are typically located above the star formation ‘main sequence’ (MS), but the offset from the MS decreases towards z ∼ 6 and towards 1010 M⊙. Our results imply a lack of evolution in the properties of LAEs across time and reveals the increasing overlap in properties of LAEs and UV-continuum selected galaxies as typical star-forming galaxies at high redshift effectively become LAEs.
Gravity and the non-linear growth of structure in the Carnegie-Spitzer-IMACS Redshift Survey
Authors: Kelson Daniel D , Abramson Louis E , Benson Andrew J , Patel Shannon G , Shectman Stephen A , Dressler Alan , McCarthy Patrick J , Mulchaey John S , Williams Rik J 
Published: January 2020

ABSTRACT
A key obstacle to developing a satisfying theory of galaxy evolution is the difficulty in extending analytic descriptions of early structure formation into full non-linearity, the regime in which galaxy growth occurs. Extant techniques, though powerful, are based on approximate numerical methods whose Monte Carlo-like nature hinders intuition building. Here, we develop a new solution to this problem and its empirical validation. We first derive closed-form analytic expectations for the evolution of fixed percentiles in the real-space cosmic density distribution, averaged over representative volumes observers can track cross-sectionally. Using the Lagrangian forms of the fluid equations, we show that percentiles in δ – the density relative to the median – should grow as $\delta (t)\propto \delta _{0}^{\alpha }\, t^{\beta }$, where α ≡ 2 and β ≡ 2 for Newtonian gravity at epochs after the overdensities transitioned to non-linear growth. We then use 9.5 square degress of Carnegie-Spitzer-IMACS Redshift Survey data to map galaxy environmental densities over 0.2 &lt; z &lt; 1.5 (∼7 Gyr) and infer α = 1.98 ± 0.04 and β = 2.01 ± 0.11 – consistent with our analytic prediction. These findings – enabled by swapping the Eulerian domain of most work on density growth for a Lagrangian approach to real-space volumetric averages – provide some of the strongest evidence that a lognormal distribution of early density fluctuations indeed decoupled from cosmic expansion to grow through gravitational accretion. They also comprise the first exact, analytic description of the non-linear growth of structure extensible to (arbitrarily) low redshift. We hope these results open the door to new modelling of, and insight-building into, galaxy growth and its diversity in cosmological contexts.
Berkeley supernova Ia program: data release of 637 spectra from 247 Type Ia supernovae
Authors: Stahl Benjamin E , Zheng WeiKang , de Jaeger Thomas , Brink Thomas G , Filippenko Alexei V , Silverman Jeffrey M , Cenko S Bradley , Clubb Kelsey I , Graham Melissa L , Halevi Goni , Kelly Patrick L , Kleiser Io , Shivvers Isaac , Yuk Heechan , Cobb Bethany E , Fox Ori D , Kandrashoff Michael T , Kong Jason J , Mauerhan Jon C , Wang Xianggao , Wang Xiaofeng 
Published: January 2020

ABSTRACT
We present 637 low-redshift optical spectra collected by the Berkeley Supernova Ia Program (BSNIP) between 2009 and 2018, almost entirely with the Kast double spectrograph on the Shane 3 m telescope at Lick Observatory. We describe our automated spectral classification scheme and arrive at a final set of 626 spectra (of 242 objects) that are unambiguously classified as belonging to Type Ia supernovae (SNe Ia). Of these, 70 spectra of 30 objects are classified as spectroscopically peculiar (i.e. not matching the spectral signatures of ‘normal’ SNe Ia) and 79 SNe Ia (covered by 328 spectra) have complementary photometric coverage. The median SN in our final set has one epoch of spectroscopy, has a redshift of 0.0208 (with a low of 0.0007 and high of 0.1921), and is first observed spectroscopically 1.1 d after maximum light. The constituent spectra are of high quality, with a median signal-to-noise ratio of 31.8 pixel−1, and have broad wavelength coverage, with $\sim\! 95{{\ \rm per\ cent}}$ covering at least 3700–9800 Å. We analyse our data set, focusing on quantitative measurements (e.g. velocities, pseudo-equivalent widths) of the evolution of prominent spectral features in the available early-time and late-time spectra. The data are available to the community, and we encourage future studies to incorporate our spectra in their analyses.
The Swift Bulge Survey: optical and near-IR follow-up featuring a likely symbiotic X-ray binary and a focused wind CV
Authors: Shaw A W , Heinke C O , Maccarone T J , Sivakoff G R , Strader J , Bahramian A , Degenaar N , Kennea J A , Kuulkers E , Rau A , Rivera Sandoval L E , Shishkovsky L , Swihart S J , Tetarenko A J , Wijnands R , in ’t Zand J J M 
Published: January 2020

ABSTRACT
The nature of very faint X-ray transients (VFXTs) – transient X-ray sources that peak at luminosities $L_X\lesssim 10^{36} {\rm \, erg \, s^{-1}}$ – is poorly understood. The faint and often short-lived outbursts make characterizing VFXTs and their multiwavelength counterparts difficult. In 2017 April we initiated the Swift Bulge Survey, a shallow X-ray survey of ∼16 square degrees around the Galactic centre with the Neil Gehrels Swift Observatory. The survey has been designed to detect new and known VFXTs, with follow-up programmes arranged to study their multiwavelength counterparts. Here we detail the optical and near-infrared follow-up of four sources detected in the first year of the Swift Bulge Survey. The known neutron star binary IGR J17445-2747 has a K4III donor, indicating a potential symbiotic X-ray binary nature and the first such source to show X-ray bursts. We also find one nearby M-dwarf (1SXPS J174215.0-291453) and one system without a clear near-IR counterpart (Swift J175233.9-290952). Finally, 3XMM J174417.2-293944 has a subgiant donor, an 8.7 d orbital period, and a likely white dwarf accretor; we argue that this is the first detection of a white dwarf accreting from a gravitationally focused wind. A key finding of our follow-up campaign is that binaries containing (sub)giant stars may make a substantial contribution to the VFXT population.
Microfluidics in male reproduction: is ex vivo culture of primate testis tissue a future strategy for ART or toxicology research?
Authors: Sharma Swati , Venzac Bastien , Burgers Thomas , Le Gac Séverine , Schlatt Stefan 
Published: January 2020

Abstract
The significant rise in male infertility disorders over the years has led to extensive research efforts to recapitulate the process of male gametogenesis in vitro and to identify essential mechanisms involved in spermatogenesis, notably for clinical applications. A promising technology to bridge this research gap is organ-on-chip (OoC) technology, which has gradually transformed the research landscape in ART and offers new opportunities to develop advanced in vitro culture systems. With exquisite control on a cell or tissue microenvironment, customized organ-specific structures can be fabricated in in vitro OoC platforms, which can also simulate the effect of in vivo vascularization. Dynamic cultures using microfluidic devices enable us to create stimulatory effect and non-stimulatory culture conditions. Noteworthy is that recent studies demonstrated the potential of continuous perfusion in OoC systems using ex vivo mouse testis tissues. Here we review the existing literature and potential applications of such OoC systems for male reproduction in combination with novel bio-engineering and analytical tools. We first introduce OoC technology and highlight the opportunities offered in reproductive biology in general. In the subsequent section, we discuss the complex structural and functional organization of the testis and the role of the vasculature-associated testicular niche and fluid dynamics in modulating testis function. Next, we review significant technological breakthroughs in achieving in vitro spermatogenesis in various species and discuss the evidence from microfluidics-based testes culture studies in mouse. Lastly, we discuss a roadmap for the potential applications of the proposed testis-on-chip culture system in the field of primate male infertility, ART and reproductive toxicology.
The Role of Smoking in Country Differences in Life Expectancy Across Europe, 1985–2014
Authors: Janssen Fanny 
Published: January 2020

Abstract

Introduction
Smoking contributes substantially to mortality levels and trends. Its role in country differences in mortality has, however, hardly been quantified. The current study formally assesses the—so far unknown—changing contribution of smoking to country differences in life expectancy at birth (e0) across Europe.

Methods
Using all-cause mortality data and indirectly estimated smoking-attributable mortality rates by age and sex for 30 European countries from 1985 to 2014, the differences in e0 between each individual European country and the weighted average were decomposed into a smoking- and a nonsmoking-related part.

Results
In 2014, e0 ranged from 70.8 years in Russia to 83.1 years in Switzerland. Men exhibited larger country differences than women (variance of 21.9 and 7.0 years, respectively). Country differences in e0 increased up to 2005 and declined thereafter. Among men, the average contribution of smoking to the country differences in e0 was highest around 1990 (47%) and declined to 35% in 2014. Among women, the average relative contribution of smoking declined from 1991 to 2011, and smoking resulted in smaller differences with the average e0 level in the majority of European countries. For both sexes combined, the contribution of smoking to country differences in e0 was higher than 20% throughout the period.

Conclusions
Smoking contributed substantially to the country differences in e0 in Europe, their increases up to 1991, and their decreases since 2005, especially among men. Policies that discourage smoking can help to reduce inequalities in mortality levels across Europe in the long run.

Implications
Smoking contributes substantially to country differences in life expectancy at birth (e0) in Europe, particularly among men, for whom the contribution was highest around 1990 (47%) and declined to 35% in 2014. In line with the anticipated progression of the smoking epidemic, the differences between European countries in e0 due to smoking are expected to further decline among men, but to increase among women. The role of smoking in mortality convergence since 2005 illustrates that smoking policies can help to reduce inequalities in life expectancy levels across Europe, particularly when they target smoking in countries with low e0.