bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dissecting the phenotypic heterogeneity in sensory features in Autism Spectrum Disorder: a factor mixture modelling approach
Authors: Tillmann Julian , Uljarevic Mirko , Crawley Daisy , Dumas Guillaume , Loth Eva , Murphy Declan , Buitelaar Jan , Charman Tony 
Published: June 2020

Abstract
Background: Heterogeneity in the phenotypic presentation of Autism Spectrum Disorder (ASD) is apparent in the profile and the severity of sensory features. Here we applied Factor Mixture Modelling (FMM) to test a multidimensional factor model of sensory processing in ASD. We aimed to identify homogeneous sensory subgroups in ASD that differ intrinsically in their severity along continuous factor scores. We also investigated sensory subgroups in relation to clinical variables: sex, age, IQ, social communication symptoms, restricted and repetitive behaviours, adaptive functioning and symptoms of anxiety and Attention-Deficit/Hyperactivity Disorder.Methods: 332 children and adults with ASD between the ages of 6 and 30 years with IQs varying between 40 and 148 were included. First, three different confirmatory factor models were fit to the 38 items of the Short Sensory Profile (SSP). Then, latent class models (with two-to-six subgroups) were evaluated. The best performing factor model, the 7-factor structure, was subsequently used in two FMMs that varied in the number of subgroups: a two-subgroup, seven-factor model and a three-subgroup, seven-factor model.Results: The ‘three-subgroup/seven-factor’ FMM was superior to all other models based on different fit criteria. Identified subgroups differed in sensory severity from severe, moderate to low. Accounting for the potential confounding effects of age and IQ, participants in these sensory subgroups had different levels of social-communicative symptoms, restricted and repetitive behaviours, adaptive functioning skills and symptoms of inattention and anxiety.Limitations: Results were derived using a single parent-report measure of sensory features, the SSP, which limits the generalisability of findings.Conclusion: Sensory features can be best described by three homogeneous sensory subgroups that differ in sensory severity gradients along seven continuous factor scores. Identified sensory subgroups were further differentiated by the severity of core and co-occurring symptoms, and level of adaptive functioning, providing novel evidence on the associated clinical correlates of sensory subgroups. These sensory subgroups provide a platform to further interrogate the neurobiological and genetic correlates of altered sensory processing in ASD.
Support Vector Machine Based Feature Extraction For Gender Recognition From Objects Using Lasso Classifier
Authors: Galla Damodara Krishna Kishore , Mukamalla BabuReddy , Chegireddy Rama Prakasha Reddy 
Published: June 2020

Abstract
The blind people has their difficulty to identify the object moving around them, therefore with a high accuracy score object detection and human face recognition system will helps them in identifying the things around them with ease. Facial record images are immobile an difficult assignment for biometric authentication systems due to various types of characteristics are dimensions, pose, expressions, illustrations and age etc. In facial and other united images includes different objects classifications. In this research article, a minimum distance trainer for feature selection by accessing SVM feature optimization process. For feature selection process SVM (support vector machine) was considered for improving its feature interpretability and computational efficiency., then LASSO classifier applied to perform object recognition and gender classification. Original face image database used for the gender classification. This approach was implemented with dual classification model (1) Recognizing or classifying human faces from various objects and (2) Classifying gender through face recognition] is made possible with the help of combining modified SIFT feature in combination with ridge regression (RR), elastic net (EN), lasso regression(LR) and lasso regression with Gaussian Support Vector Machines (LRGS) based classification.
A Momentary Impact Injury of Vertebral Endplates, even without Structural Disruption, Initiates Disc Degeneration In Vitro.
Authors: Sun Zhengang , Wang Xiaoshuai , Jiang Yongjie , Chen Guoliang , Ling Zenmin , Yang Jiaming , Pan Ximin , Liu Xizhe , Liu Shaoyu , Ye Wei , Wei Fuxin 
Published: June 2020

Abstract
Background ： It has been acknowledged that the intervertebral disc degeneration(IDD) is associated with an aberrant cell-medicated response to structural failures, such as vertebral burst fracture, radial fissures, and endplate fracture. However, whether a momentary impact injury of the endplates without structural disruption, is sufficiently to initiate disc degeneration remains elusive. This study was to further evolve an in vitro momentary impact injury model of IDD and to investigate if a momentary impact load of the endplates without structural disruption could initiate IDD.

Methods. Rat spinal segments (from L1/2 to L5/6, n=54) were harvested and randomly assigned into three groups: Control (n=18), Low Impact (12 J/cm 3 , n=18) and High Impact (25 J/cm 3 , n=18). Samples in both of the impact groups were subjected to axial momentary impact load using a custom-made apparatus, and cultured for 14 days. The degenerative process was investigated by using histomorphology and real-time PCR.

Results: The discs in both of the impact groups showed significant degenerative changes at 14 days, both of which showed much higher histological scores and up-regulation of the catabolic (MMP-9, MMP-13) genes transcription than that of the control group ( P ＜0.05). The discs with endplate fracture compared to that with intact endplate also showed strongly up-regulated catabolic (MMP-9, MMP-13) genes transcription, and more significant degenerative changes based on the histological scoring ( P ＜0.05).

Conclusion: This study demonstrated that a momentary impact load (12 J/cm 3 ) on the spinal segments of the rats could initiate IDD at 14 days after injury and not only endplate fracture but also a momentary impact injury without structural disruption could also promote IDD.
Priority domains, aims, and testable hypotheses for implementation research: Protocol for a scoping review and evidence map
Authors: Garner Bryan R , Patel Sheila , Kirk M. Alexis 
Published: June 2020

Abstract
Background: The challenge of implementing evidence-based innovations within practice settings is a significant public health issue the field of implementation research (IR) is focused on addressing. Significant amounts of funding, time, and effort have been invested in IR to date, yet there remains significant room for advancement, especially regarding IR’s development of scientific theories as defined by the National Academy of Sciences (i.e., a comprehensive explanation of the relationship between variables that is supported by a vast body of evidence). Research priority setting (i.e., promoting consensus about areas where research effort will have wide benefits to society) is a key approach to helping accelerate research advancements. Thus, building upon existing IR, general principles of data reduction, and a general framework for moderated mediation, this article identifies four priority domains, three priority aims, and four testable hypotheses for IR, which we organize in the priority aims and testable hypotheses (PATH) diagram..Methods: The objective of this scoping review is to map the extent to which IR has examined the identified PATH priorities to date. Because Implementation Science is the leading journal for publishing IR and receives over 800 submissions annually, our sample will include IR (specifically, original research articles and short reports) published in Implementation Science between its inception in 2006 and December 2019. The protocol for the current scoping review and evidence map has been developed in accordance with the approach developed by Arksey & O’Malley and advanced by Levac, Colquhoun, and O’Brien. Because scoping reviews seek to provide an overview of the identified evidence base rather than synthesize findings from across studies, we plan to use our data-charting form to provide a descriptive overview of implementation research to-date and summarize the research via one or more summary tables. We will use the PATH diagram to organize a map of the evidence to date.Discussion: This scoping review and evidence map is intended to help accelerate IR focused on suggested priority aims and testable hypotheses, which in turn will accelerate IR’s development of National Academy of Sciences-defined scientific theories and, subsequently, improvements in public health.Systematic review registration: Open Science Framework: https://osf.io/3vhuj/
Is all-inside with suspensory cortical button fixation a superior technique for anterior cruciate ligament reconstruction surgery? A systematic review and meta-analysis
Authors: Fu Chun Wei , Chen Wei-Cheng , Lu Yung-Chang 
Published: June 2020

Abstract
Background To compare the clinical results of all-inside anterior cruciate ligament reconstruction (ACLR) using suspensory cortical button fixation and full tibial tunnel drilling Methods Systematic searches were conducted of published literature up to November 2019 on PubMed, Embase, and Cochrane for studies comparing all-inside ACLR using suspensory cortical button fixation and full tibial tunnel ACLR. Two reviewers independently determined eligibility, extracted the outcome data, and assessed the risk of bias of the eligible studies. The clinical outcome and graft reruptures were pooled by using random effects with mean differences and risk ratios for continuous and dichotomous variables, respectively. Result A total of nine studies (five randomized controlled trials and four comparative studies) involving 613 patients were included in the meta-analysis. The postoperative functional outcome, knee laxity measured with arthrometer, and graft reruptures were comparable between patients with all-inside ACLR using suspensory cortical button fixation and full tibial tunnel ACLR. However, a significantly greater thickness of autologous tendon was used and less change in drilling tunnel diameter was noted in patients with suspensory cortical button graft fixation.Conclusions All-inside ACLR with suspensory cortical button fixation was not clinically superior to full tibial tunnel ACLR with interference screw fixation in functional outcomes, knee laxity measured with arthrometer, or rerupture rate. However, the advantage of using suspensory cortical button fixation was that a thicker graft could be used for reconstruction, and brought less tibia tunnel widening compared with bioabsorbable interference screw fixation.
Genetic Determinants of Obesity Heterogeneity in Type II Diabetes
Authors: Khorami Somayeh Alsadat Hosseini , Mutalib Mohd Sokhini Abd , Shiraz Mohammad Feili , Abdullah Joseph Anthony , Rejali Zulida , Ali Razana Mohd , Khaza'ai Huzwah 
Published: June 2020

Abstract
Background: Although obesity is considered as the main cause of Type II diabetes (T2DM), non-obese individuals may still develop T2DM and obese individuals may not. Method: The mRNA expression of PI3K/AKT axis from 100 non-obese and obese participants with insulin sensitivity and insulin resistance states were compared in this study toward the understanding of obesity heterogeneity molecular mechanism. Result: In present study, there was no statistically significant difference in gene expression levels of IRS1 and PTEN between groups, whereas PI3K, AKT2 and GLUT4 genes were expressed at a lower level in obese diabetic group compared to other groups and were statistically significant. PDK1 gene was expressed at a higher level in non-obese diabetic group compared to obese diabetic and non-obese non-diabetics groups. No statistically significant difference was identified in gene expression pattern of PI3K/AKT pathway between obese non-diabetics and non-obese non-diabetics.Conclusion: The components of PI3K/AKT pathway which is related to the fasting state, showed reduced expression in obese diabetic group due to the chronic over-nutrition which may induced insensitivity and reduced gene expression. The pathogenesis of insulin resistance in the absence of obesity in non-obese diabetic group could be due to disturbance in another pathway related to the non-fasting state like gluconeogenesis. Therefore, the molecular mechanism of insulin signalling in non-obese diabetic individuals is different from obese diabetics which more investigations are required to study insulin signalling pathways in greater depth, in order to assess nutritional factors, contribute to insulin resistance in obese diabetic and non-obese diabetic individuals.
Does a ketogenic diet have beneficial effects on quality of life, physical activity or biomarkers in patients with breast cancer: A randomized controlled clinical trial.
Authors: khodabakhshi adeleh , Akbari Mohammad Esmaeil , Seyfried Thomas N. , Mahmoudi Maryam , Kalamian Miriam , Moradi Nariman , beheshti maryam , Davoodi Sayed Hossein 
Published: June 2020

Abstract
Introduction: Despite recent interest in the use of ketogenic diets (KDs) for cancer , evidence of beneficial effects is lacking. This study examined the impact of a randomly assigned KD on quality of life, physical activity and biomarkers in patients with breast cancer. Method: A total of 80 patients with locally advanced or metastatic breast cancer and without a history of renal disease or diabetes were randomly assigned to either a KD or a control group for this 12-week trial. Concurrent with the first, third, and fifth chemotherapy sessions, quality of life, physical activity, and biomarkers (thyroid function tests, electrolytes, albumin, ammonia, ALP, lactate and serum ketones) were assessed. Dietary intake was also recorded on admission and the end of the treatment. Results: No significant differences were seen in quality of life or physical activity scores between the two groups after 12 weeks; however, the KD group showed higher global quality of life and physical activity scores compared to the control group at 6 weeks (P=0.02 P= 0.01). Also, serum lactate and ALP levels decreased significantly in the KD group compared to the control group at the end of the intervention (10.7±3 vs 13.3±4, 149±71 vs 240±164, P=0.02 and P=0.007, respectively). A significant inverse association was observed between total carbohydrate intake and serum beta-hydroxybutyrate at 12 weeks (r= -0.77 P <0.001). No significant differences between groups were observed in thyroid hormones, electrolytes, albumin, LDH or ammonia. Compliance among KD subjects ranged from 66.7% to 79.2% as assessed by dietary intake and serum ketones levels of >0.5. Conclusion: According to our results, chemotherapy combined with 6 weeks of a KD improved global quality of life and physical activity scores but did not result in similar improvements at 12 weeks. There were no significant differences noted in thyroid function or electrolyte levels between the two groups. However, decreases seen in levels of lactate and ALP in the KD group suggest that a KD may benefit patients with breast cancer
A high triglyceride glucose index is more closely associated with hypertension than lipid or glycemic parameters in elderly individuals: a cross-sectional survey from the Reaction Study.
Authors: Zhu Binruo , Wang Jie , Chen Kang , Yan Wenhua , Wang Anping , Wang Weiqing , Gao Zhengnan , Tang Xulei , Yan Li , Wan Qin , Luo Zuojie , Qin Guijun , Chen Lulu , Mu Yiming 
Published: June 2020

Abstract
Background: Both lipid and glucose abnormalities are associated with hypertension (HTN). However, it is unclear whether the triglyceride-glucose (TyG) index is associated with HTN. Therefore the aim of this study is to investigate the association of the TyG index and HTN and to compare the discriminative power of the TyG index, lipid, glycemic parameters for the risk of HTN in elderly individuals.Methods: The present study was nested in a longitudinal (REACTION) study from May 2011 to December 2011, which was designed to demonstrate the association of abnormal glucose metabolism with the risk of cancer in the Chinese population. In total, 47808 participants were recruited in this cross-sectional study. The TyG index was divided into five groups: the <20% group, the 20-39% group, the 40-59% group, the 60-79% group and the ≥80% group, according to quintile division of the subjects. Three multivariate logistic regression models were used to evaluate the association between the TyG vs. lipid parameters, glycemic parameters and HTN.Results: Multivariate logistic regression analysis shows that compared with lipid and glycemic parameters, the TyG index remains significantly associated with HTN in either total subjects or subjects separated into men and women (odds ratio (OR) 1.33, 95% confidence interval (CI) 1.18-1.51, p <0.0001 in total subjects; OR 1.39, 95% CI 1.11-1.74, p=0.0042 in men; OR 1.28, 95% CI 1.11-1.49, p=0.0010 in women). In a stratified analysis, an elevated TyG index is significantly associated with HTN in the subgroup of the oldest age (≥65) (OR 1.67, 95% CI 1.30-2.14, p <0.0001), as well as with obesity (Body mass index (BMI) ≥28 kg/m2) (OR 1.85, 95% CI 1.29-2.66, p=0.0009) or lower estimated glomerular filtration rate (eGFR) (<90 mL/ (min·1.73 m2)) (OR 1.72, 95% CI 1.33-2.21, p <0.0001).Conclusion: The TyG index is significantly associated with HTN and shows the superior discriminative ability for HTN compared with lipid and glycemic parameters in the Chinese elderly population.
Ultrasonic bone scalpel for thoracic spinal decompression: case series and technical note
Authors: Sun Chuiguo , Chen Guanghui , Fan Tianqi , Li Weishi , Guo Zhaoqing , Qi Qiang , Zeng Yan , Zhong Woquan , chen zhongqiang 
Published: June 2020

Abstract
Background: Thoracic spinal stenosis (TSS) is a rare but intractable disease that fails to respond to conservative treatment. Thoracic spinal decompression, which is traditionally performed using high-speed drills and kerrison rongeurs, is a time-consuming and technically challenging task. Unfavorable outcomes and high incidence of complications are the major concerns. The development and adaptation of ultrasonic bone scalpel (UBS) has promoted its application in various spinal operations, but its application and standard operating procedure in thoracic decompression have not been fully clarified. Therefore, the purpose of this study is to describe our experience and technique note of using UBS, and come up with a standard surgical procedure for thoracic spinal decompression.Methods: A consecutive of 28 patients with TSS who underwent posterior thoracic spinal decompression surgery with UBS between December 2014 and May 2015 were enrolled in this study. The demographic data, perioperative complications, operation time, estimated blood loss, pre-and postoperative neurological statuses were recorded and analyzed. Neurological status was evaluated with a modified Japanese Orthopaedic Association (JOA) scale and the neurological recovery rate was calculated using the Hirabayashi’s Method.Results: Thoracic spinal decompression surgery was successfully carried out in all cases via a single posterior approach. The average age at surgery was 49.7±8.5 years. The mean operative time of single-segment laminectomy was 3.0±1.4min and the blood loss was 108.3±47.3ml. In circumferential decompression, the average blood loss was 513.8±217.0ml. Two cases of instrument-related nerve root injury occurred during operation and were cured by conservative treatment. Six patients experienced cerebrospinal fluid (CSF) leakage postoperatively, but no related complications were observed. The mean follow-up period was 39.7±8.9 months, the average JOA score increased from 4.7 before surgery to 10.1 postoperatively, and the average recovery rate was 85.8%. Conclusions: The UBS is an optimal instrument for thoracic spinal decompression, and its application enables surgeons to decompress the thoracic spinal cord safely and effectively. This standard operating procedure is expected to help achieve favorable outcomes, and can be used to treat various pathologies leading to TSS.
External validation of the European risk assessment tool for Chronic Cardio-metabolic disorders in a Middle Eastern population
Authors: Asgari Samaneh , Moosaie Fatemeh , Khalili Davood , Azizi Fereidoun , Hadaegh Farzad 
Published: June 2020

Abstract
Background: High burden of chronic cardio-metabolic disorders including type 2 diabetes mellitus (T2DM), chronic kidney disease (CKD), and cardiovascular disease (CVD) have been reported in the Middle East and North Africa region. We aimed to externally validate a non-laboratory risk assessment tool for the prediction of the chronic cardio-metabolic disorders in the Iranian population. Methods: The predictors included age, body mass index, waist circumference, use of antihypertensive, current smoking, and family history of cardiovascular disease and/or diabetes. For external validation of the model in the Tehran lipids and glucose study (TLGS), the Area under the curve (AUC) and the Hosmer-Lemeshow (HL) goodness of fit test were performed for discrimination and calibration, respectively. Results: Among 1310 men and 1960 women aged 28-85 years, 29.5% and 47.4% experienced chronic cardio-metabolic disorders during the 6 and 9-year follow-up, respectively. The model showed acceptable discrimination, with an AUC of 0.72(95% CI: 0.69-0.75) for men and 0.73(95% CI: 0.71-0.76) for women. The calibration of the model was good for both genders (min HL P=0.5). Considering separate outcomes, AUC was highest for CKD (0.76(95% CI: 0.72-0.79)) and lowest for T2DM (0.65(95% CI: 0.61-0.69)), in men. As for women, AUC was highest for CVD (0.82(95% CI: 0.78-0.86)) and lowest for T2DM (0.69(95% CI: 0.66-0.73)). The 9-year follow-up demonstrated almost similar performances compared to the 6-year follow-up. Using Cox regression in place of logistic multivariable analysis, model’s discrimination and calibration were reduced for prediction of chronic cardio-metabolic disorders; the issue which had more effect on the prediction of incident CKD among women. Moreover, adding data of educational levels and marital status did not improve, the discrimination and calibration in the enhanced model.Conclusion: This model showed acceptable discrimination and good calibration for risk prediction of chronic cardio-metabolic disorders in short and long-term follow-up in the Iranian population.