bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancement of tendon-bone interface healing and graft maturation with cylindrical Titanium-Web (TW) in a miniature swine anterior cruciate ligament reconstruction model: Histological and collagen-based analysis
Authors: Ryu Keisho , Saito Mitsuru , Kurosaka Daisaburo , Kitasato Seiichiro , Omori Toshiyuki , Hayashi Hiroteru , Kayama Tomohiro , Marumo Keishi 
Published: December 2019

Abstract
Background: Tendon-bone interface healing and ligamentization of the graft in anterior cruciate ligament (ACL) reconstruction with autografts are important factors affecting treatment outcome. This study aimed to investigate the effectiveness of a cylindrical titanium-web (TW) in tendon-bone interface healing and graft maturation in ACL reconstruction.Methods: Fourteen mature female CLAWN miniature swine underwent bilateral ACL reconstructions with patellar tendon (PT) autografts. In one limb, the TW/tendon complex was placed into the proximal side of the tibial tunnel. Only the graft was transplanted into the tunnel in the control limb. The proximal side of the graft was sutured into the stump of the native ACL and the distal end was stapled to the tibia. The animals were euthanized at 4 and 15 weeks postoperatively, for histological and biochemical analyses. Results: Microscopic images in TW limbs showed that ingrowth of tendon-like tissue and mineralized bone tissue into the TW connected the bone and the tendon directly. In contrast, fibrous tissue intervened between the bone and tendon in the control limbs. The total amount of collagen cross-links (which defines the strength of collagen fibers) and the maturation of collagen cross-links in TW tendons were significantly higher (p<0.05) than those of control limbs. There was no significant difference in the ratio of dihydroxy-lysinonorleucine to hydroxy-lysinonorleucine (an indicator of tissue specific collagen maturation) between TW tendons and that of the native PT. Conclusions: TW promoted the maturation and formation of collagen cross-links in the grafted tendon while maintaining the cross-link pattern of native tendon collagen, and enabled direct binding of tendon to bone.
Association between genetic polymorphism of XRCC7 (G6721T) and acute lymphoblastic leukemia risk
Authors: Farokhian Farnoush , beyzaei zahra , Ramzi Mani , Geramizadeh Bita , Mokhtari Mohamad Javad 
Published: December 2019

Abstract
Background: One of the most important DNA double-strand break (DSBs) repair genes is XRCC7 involved in non-homologous end joining (NHEJ). It is supposed that DNA repair gene malfunction is an important risk factor in various malignancies. The XRCC7 G6721T (rs7003908) polymorphism effect were investigated on the splicing regulation that cause mRNA instability. Objective: The aim of present hospital-based study was to investigate the association between the G6721T common genetic polymorphism of XRCC7 and risk of acute lymphoblastic leukemia (ALL). Methods: This case–control study was performed on 99 ALL patients versus 200 healthy blood donors (children), as the control group. Controls had no history of ALL, and they were frequent-matched by age with cases. The polymorphism of XRCC7 was determined using an RFLP-PCR method. Results: The GT (OR= 1.485, 95% CI: 0.765-2.334, P=0.243) and TT (OR= 1.655, 95% CI: 00.875-3.128, P=0.121) genotypes had no significant effect on risk of ALL, in comparison with the GG genotype. Hence, TT genotype (OR= 1.996, 95% CI: 1.033-3.858, P=0.04) after adjusting for parents smoking pattern showed a significant effect. Conclusion: The presence of the TT genotype may be increase the risk of ALL in children when facing with a Tobacco smoke.
Prognostic value of tumor-infiltrating lymphocytes in patients with triple-negative breast cancer: a systematic review and meta-analysis
Authors: Gao Guoxuan , Wang Zihan , Qu Xiang , Zhang Zhongtao 
Published: December 2019

Abstract
Objective The objective of this systematic review and meta-analysis is to determine prognostic roles of the total tumor-infiltrating lymphocytes (TILs) or subtypes of TILs (CD4+, CD8+, and FOSP3+) for patients with triple-negative breast cancer (TNBC).Methods A systematic literature search was conducted in the databases of MEDLINE, EMBASE, and Web of Science to identified eligible articles before August 2019. Study screening, data extraction, and risk of bias were performed by two independent reviewers. Risk of bias on study level was assessed using an approach based on the ROBINS I tool and the Quality In Prognosis Studies (QUIPS) tool. We performed meta-analyses to obtain a pooled estimate of the prognostic role of TILS using Review Manager 5.3.Results There was total of 37 studies included in the final analysis. Compared to TNBC patients with poor TILs, TNBC patients with rich TILs had a higher pCR to treatments (OR 2.14, 95% CI 1.43-3.19). Along with per 10% increase of the TILs, patients with TNBC had an increased pCR (OR 1.09, 95% CI 1.02-1.16). Compared to TNBC patients with poor TILs, patients with rich TILs had a better OS (HR 0.58, 95% CI 0.48-0.71) and DFS (HR 0.66, 95% CI 0.57-0.76). Addition to, along with a continuous increase of the TILs, patients with TNBC had improved OS (HR 0.90, 95% CI 0.87-0.93) and DFS (HR 0.92, 95% CI 0.90-0.95) as well. CD4+TILs subgroup (rich vs. poor) showed a better OS (HR 0.49, 95%CI 0.32-0.76) and DFS (HR 0.54, 95%CI 0.36-0.80). CD8+TILs subgroup (rich vs. poor) showed a better DFS (HR 0.55, 95% CI 0.38-0.81), but no statistical association was found with OS (HR 0.70, 95% CI 0.46-1.06). FOXP3+TILs subgroup (rich vs. poor) showed a better DFS (HR 0.50, 95% CI 0.33-0.75), but no statistical association was found with OS (HR 1.28, 95% CI 0.24-6.88).Conclusion TNBC with higher levels of TILs showed better short-term and long-term prognosis. The phenotypes of TILs (CD4+TILs, CD8+TILs, and FOXP3+TILs) had positive prediction for long-term prognosis for TNBC.
The association between physicians’presenteeism and job burnout: a cross-sectional survey study in China
Authors: pei pei , Lin Guohua , Li Gaojie , Zhu Yifan , Xi Xiaoyu 
Published: December 2019

Abstract
Background: Research shows that physicians often report job burnout and have a high level of presenteeism, but few studies concerns the relationship between job burnout and presenteeism. The purpose of this study was to explore the relationship between physicians’ presenteeism and three dimensions of job burnout in China, and to identify aspects that can help alleviate presenteeism. Methods: A cross-sectional survey involving physicians in second-and third-class medical institutions was conducted in the interior of China. Using a single presenteeism questionnaire and a 15-item Chinese version of the BMI-GS questionnaire, this study investigated prevalence of physicians' presenteeism behavior and job burnout in three dimensions, and determined the relationship between presenteeism and job burnout by logistical model. Results: Relationships between presenteeism and three dimensions of job burnout were explored, and the influence of demography and work factors were evaluated. The survey was completed by 1376/1547 hospital doctors, with a response rate of 88.9%. 30.7%(n=422) of the subjects reported having presenteeism behavior. Using MBI-GS, 86.8%(n=1195) of physicians were moderately burnout and 6.0%(n=82) were severely job burnout. Logistic regression analysis showed that physicians with moderate, severe emotional exhaustion and severe cynicism were more likely to engage in presenteeism (all p < 0.05). In addition, two other work-related factors, including the physician's department and position, were also more likely to influence their presenteeism (all p < 0.05). Conclusions: At present, there is quite presenteeism among physicians in the second-and third-class medical institutions in China, which is significantly related to emotional exhaustion and cynicism. Considering the modifiable job-related factors, health care institutions must take appropriate measures to relieve physicians' job burnout, help them adjust their self-awareness properly, and ensure occupational mental health to alleviate the prevalence of presenteeism. Keywords: presenteeism, job burnout, emotional exhaustion, cynicism, physicians
Undesirable Perioperative Anesthesia Outcomes at Two National Referral Hospitals, a cross sectional study in Eritrea
Authors: Andemeskel Yonatan Mehari , Elsholz Traudl , Gebreyohannes Ghidey , Tesfamariam Eyasu H. 
Published: December 2019

Abstract
Background: Perioperative undesirable anesthesia outcomes are common among patients undergoing surgery. The aim of this study was to assess the prevalence of undesirable anaesthesia outcomes during the perioperative period. Method: This cross sectional study was conducted on 470 patient who underwent different types of surgeries at two National Referral Hospitals with in a three month period. Patients were interviewed 24 hours after operation using the dimension “Discomfort and needs” of the Leiden preoperative care patient satisfaction questionnaire (LPPSq). Descriptive analysis was done using SPSS (version 22) to compute the percentage of occurrence of these undesirable outcomes. Odds ratio was computed using logistic regression to look for the association of the outcomes with the type of surgery and type of anesthesia. Statistical significance level was set at p<0.05. Results: The prevalence of these outcomes was computed in two sequences; prevalence A and prevalence B. Of all the outcomes, post-operative pain was found to be the most prevalent outcome scoring 82.6% and 43.6% consecutively in both prevalence with a median score of 1. The rest of the post-operative side effects were less frequently reported with a median score of 0. In those who did general surgery, sore throat was observed 5.49 times more among those who took general anesthesia (p <0.001). The occurrence of nausea and vomiting was also higher among the same patients in which nausea occurred 1.74 times more (p<0.05) and vomiting 2.03 more (p<0.05). While back pain occurred 51% less among these patients (p <0.05). In those patients who had orthopedic surgeries significant differences was observed only in the occurrences of sore throat in which it was experienced 5.37 times more (p<0.01) by those patients who took general anaesthesia. While in those patients who did gyn/obs surgery, the occurrence of back pain was significant in which was 67% higher among those who took general anaesthesia Conclusion: The experience of undesirable anesthesia outcomes is generally low except for postoperative pain. More emphasis is needed on the management of postoperative pain. Keywords: Leiden preoperative care patient satisfaction questionnaire (LPPSq), Perioperative care, Surgery, Undesirable anesthesia outcomes.
Low district economic performance presents strong oral health determinant in preschool children: country level analysis
Authors: Vukovic Ana , Soldatovic Ivan , Vukovic Rade , Peric Tamara , Campus Guglielmo , Markovic Dejan 
Published: December 2019

Abstract
Background: Having in mind that macro level factors such as social, political and economic determinants strongly impact occurrence of chronic NCDs, it might be beneficial to enlarge scarce level of data on the influence of these factors on children’s oral health. The aim of the present study was to test association between macro level factors and oral health in a nationally representative sample of preschoolers involving all preschooler’s age groups from the beginning to compulsory Preschool Preparatory Program. Method: Oral health data derived from cross sectional study involving nationally representative sample of preschool children. Dependent, oral health variables included prevalence of primary teeth caries, untreated caries, and caries on permanent first molars. Data on macro level factors included regional information on economic, population, and healthcare factors: population density, density of physicians and dentists, district share in national gross domestic product (GDP), social and health care expenditures, local self-government budget, employment rate in public, private and agricultural sector. In order to have nationally representative sample we used stratified cluster sampling method proposed by World Health Organization. Results: Final sample included 1665 preschoolers aged 36 to 91 months. Observed prevalence of ECC was 57.8%. Of these, 90.4% had untreated caries. Furthermore, 11.1% of examined preschoolers already had lesions on permanent first molar. All ECC related oral health outcomes were statistically significantly associated with regional social economic indicators – poor oral health was more frequently observed in regions and districts with lower economic performance. Conclusions: The results of this study displayed first nationally representative data on prevalence of primary teeth caries in preschool children. Noteworthy findings confirmed highly statistically significant association of economic macro level factors with prevalence of primary teeth caries, untreated caries, and caries on permanent first molars. Upstream preventive interventions especially targeted at population living in districts with lower economic indicators might seem as most appropriate strategy.
Intelligent Cloud Workflow Management and Scheduling Method for Big Data Applications
Authors: Hu Yannian , Wang Hui , Ma Wenge 
Published: December 2019

Abstract
With the application and comprehensive development of big data, the need for effective research on cloud workflow management and scheduling is becoming more and more urgent. However, there are currently suitable methods for effective analysis. In order to find out how to effectively manage and schedule smart cloud workflows, the article studies big data from different aspects and draws the following conclusions: Compared with the original JStorm system, the average response time is shortened by up to 58.26%, and the average is shortened. 23.18%; CPU resource utilization increased by 17.96%, an average increase of 11.39%; memory utilization increased by 88.7%, an average increase of 71.16%. In optimizing the dynamic combination of web services, the overall performance of MOACO algorithm and CCA algorithm is better than GA algorithm, and the average performance of MOACO algorithm is better than CCA algorithm. The paper also proposes a cloud workflow scheduling strategy based on intelligent algorithms and adjusting the perceived cloud service resource combination strategy to realize two-layer scheduling of cloud workflow tasks. We have studied three representative intelligent algorithms (ACO algorithm, PSO algorithm and GA algorithm) and designed and improved them for scheduling optimization. It can be clearly seen that in the same scenario, in different test cases the optimal values of the different algorithms vary greatly. However, the optimal solution curve is substantially consistent with the trend of the mean curve.
THE EAGLE JUGULAR SYNDROME
Authors: Zamboni Paolo , Scerrati Alba , Menegatti Erica , Galeotti Roberto , Lapparelli Marcello , Traina Luca , Tessari Mirko , Ciorba Andrea , De Bonis Pasquale , Pelucchi Stefano 
Published: December 2019

Abstract
Background : The elongation of the styloid process is historically associated with two variants of the Eagle syndrome. The classic one, mainly characterized by pain and dysphagia, and the carotid variant characterized by pain and sometimes by cerebral ischemia. We observed a further variant characterized by a styloid elongation coursing adjacent to the transverse process of C1, causing significant compression of the internal jugular vein.
Methods : We reviewed all the cases of Eagle syndrome, including the jugular variant, admitted in our Hospital in the last six years.
We compared symptomatology, associated comorbidities and imaging. Data were statistically analyzed.
Results : Overall 23 patients were admitted to the Hospital for symptomatic elongation of the styloid process, 11 male and 12 females. The jugular variant of the Eagle syndrome is clinically delineated by significant differences, as compared to the classic variant and carotid variants. Headache was the more prominent symptom (p<.009) as well as a documented peri-mesencephalic hemorrhage was the more significant comorbidity (p<.0003). The group classic-carotid variant was characterized by ipsilateral pain respect to the jugular variant (p<.0003). CT angiography with venous phase extended to the neck veins and imaging reconstruction is highly recommended as imaging technique, complemented by color-Doppler ultrasound.
Conclusions : The elongation of the styloid process may have different paths which creates compression on the surrounding anatomical structures. There may be a possible association of jugular impingement by an elongated styloid process with symptoms.
The Role and Impact of Merger & Acquisition of Banking Sector in Pakistan
Authors: Kishwar A. , Ullah A. 
Published: December 2019

Authors:
Kishwar Ali, School of Finance, Zhongnan University of Economics & Law, Wuhan, China
Atta Ullah, School of management, Huazhong University of Science and Technology, Wuhan China
Pages: 113-121
DOI: http://doi.org/10.21272/fmir.3(3).113-121.2019

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Abstract

The paper summarizes the arguments and counterarguments in the scientific discussion on determining the effects of mergers and acquisitions for banking institutions. The purpose of this article is to conduct an empirical study to identify the nature of the impact of mergers and acquisitions on Pakistan’s financial sector performance. The research in the article is carried out in the following logical sequence: a thorough literature review on the analysis of key aspects of mergers and acquisitions and their impact on the financial and economic performance of banks before and after their practical implementation; the historical basis of the experience of mergers and acquisitions caused by various economic factors, such as: GDP growth, interest rates on loans, monetary policy; financial analysis of bank profitability, solvency and liquidity indicators before and after the merger and acquisition was conducted. Five commercial banks of Pakistan that were involved in the merger and acquisition processes were selected as the subject of study. The study period is presented before and after the merger and includes two years before the acquisition report and two years after the acquisition announcement by analysis of financial ratios of liquidity, solvency and profitability. The results of empirical and theoretical research have shown that there is a positive relationship between merger and acquisition processes and liquidity ratios of banking institutions; and – the negative impact of such processes on banks’ profitability and solvency in the short term. The author states that the main limitation of the study is the unavailability of financial data until 2006 and the use of a small sample size and a low likelihood of data collection technique, which is limited by a certain type of people and lack of generalization.
Keywords: merger, acquisition, bank, solvency risk, liquidity, profitability.
KANDUNGAN BUAH-BUAHAN DALAM ALQUR’AN: BUAH TIN (Ficus carica L), ZAITUN (Olea europea L), DELIMA (Punica granatum L), ANGGUR (Vitis vinivera L), DAN KURMA (Phoenix dactylifera L) UNTUK KESEHATAN
Authors: Khasanah Nur 
Published: December 2019

Aneka ragam buah-buahan segar diciptakan Sang Khalik untuk umat manusia. Di antara sekian banyak buah-buahan itu, salah satu yang disebutkan Allah SWT dalam Alquran. Adalah buah tin, zaitun, delima, anggur, dan kurma. Untuk itulah kita sebagai muslim perlu men- getahui zat-zat yang terkandung dalam buah tersebut, se- hingga dapat memanfaatkan buah tersebut dengan sebaik- baiknya. Tidak ada sekecil apa pun Allah ciptaan jika tidak membawa kemanfaatan bagi manusia.
MODEL PEMBELAJARAN CREATIVE PROBLEM SOLVING DENGAN VIDEO COMPACT DISK UNTUK MENCAPAI KOMPETENSI DASAR DALAM PEMBELAJARAN MATEMATIKA DI MTs
Authors: S Saminanto 
Published: December 2019

Matematika adalah mata pelajaran yang diajarkan dari jenjang pendidikan dasar sampai pendidikan menengah. Selain mempunyai sifat yang abstrak, pemahaman konsep matematika yang baik sangatlah penting karena untuk me- mahami konsep yang baru diperlukan prasarat pemaha- man konsep sebelumnya. Dalam proses belajar mengajar guru mempunyai tugas untuk memilih model pembelaja- ran berikut media yang tepat sesuai dengan materi yang disampaikan demi tercapainya tujuan pembelajaran. Sam- pai saat ini masih banyak ditemui kesulitan siswa untuk mempelajari konsep geometri, antara lain tentang persegi panjang dan persegi pada siswa kelas VII semester 2. Aki- batnya terjadi kesulitan siswa untuk memahami konsep geometri selanjutnya karena konsep prasarat belum dipa- hami. Model pembelajaran Creative Problem Solving dengan Media Video Compact Disk sangat dimungkinkan bisa menin- gkatkan pemahaman konsep, keaktifan, dan hasil belajar siswa. Model pembelajaran ini dapat dijadikan alternatif pada pembelajaran matematika karena sesuai dengan karak- teristik matematika dan tuntutan Kurikulum 2006. Peneli- tian tindakan kelas/penelitian perbaikan pembelajaran ini mengambil obyek Kota Semarang, dan mengambil sampel di MTsN 1 Kota Semarang. Data yang diperoleh diolah se- cara deskriptif.Pelaksanaan penelitian dibagi dalam dua siklus, yang tiap siklusnya terdiri dari perencanaan, pelaksanaan, pen- gamatan dan refleksi. Hasil pengamatan dan refleksi akan dijadikan bahan rujukan untuk pelaksanaan siklus berikut- nya. Sehingga proses dan hasil pelaksanaan siklus berikut- nya diharapkan akan lebih baik dari siklus sebelumnya. Dari tiap siklus akan diukur proses keaktifan dan proses bermain peran, dan keberhasilan siswa dalam pembela- jaran dengan model pembelajaran creative problem solving dengan media video compact disk.Hasil penelitian menunjukan bahwa pembelajaran matematika menggunakan model pembelajaran creative problem solving dengan media video compact disk dapat me- ningkatkan pemahaman konsep, keaktifan, dan hasil bela- jar siswa di MTs.