bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Classic Lobe Eye Phenotype of Drosophila Is Caused by Transposon Insertion-Induced Misexpression of a Zinc-Finger Transcription Factor
Authors: Son Wonseok , Choi Kwang-Wook 
Published: July 2020

Abstract
Dr osophila Lobe (L) alleles were first discovered ∼100 years ago as spontaneous dominant mutants with characteristic developmental eye defects. However, the molecular basis for L dominant eye phenotypes has not been clearly understood. A previous work reported identification of CG10109/PRAS40 as the L gene, but subsequent analyses suggested that PRAS40 may not be related to L. Here, we revisited the L gene to clarify this discrepancy and understand the basis for the dominance of L mutations. Genetic analysis localized the L gene to Oaz, which encodes a homolog of the vertebrate zinc finger protein 423 (Zfp423) family transcriptional regulators. We demonstrate that RNAi knockdown of Oaz almost completely restores all L dominant alleles tested. Lrev6-3, a revertant allele of the L2 dominant eye phenotype, has an inframe deletion in the Oaz coding sequence. Molecular analysis of L dominant mutants identified allele-specific insertions of natural transposons (roo[ ]L1, hopper[ ]L5, and roo[ ]Lr) or alterations of a preexisting transposon (L2-specific mutations in roo[ ]Mohr) in the Oaz region. In addition, we generated additional L2-reversion alleles by CRISPR targeting at Oaz. These new loss-of-function Oaz mutations suppress the dominant L eye phenotype. Oaz protein is not expressed in wild-type eye disc but is expressed ectopically in L2/+ mutant eye disc. We induced male recombination between Oaz-GAL4 insertions and the L2 mutation through homologous recombination. By using the L2-recombined GAL4 reporters, we show that Oaz-GAL4 is expressed ectopically in L2 eye imaginal disc. Taken together, our data suggest that neomorphic L eye phenotypes are likely due to misregulation of Oaz by spontaneous transposon insertions.
Autonomia do usuário na implementação de práticas integrativas complementares
Authors: Ferraz Ivana Santos , Cardoso Climaco Layres Canuta , Silva de Oliveira Boery Rita Narriman , Yarid Sérgio Donha , Da Silva Sena Edite Lago , Martins Filho Ismar Eduardo 
Published: July 2020

Esse estudo teve como objetivo desenvolver uma reflexão bioética acerca da autonomia dos usuários submetidos às Práticas Integrativas Complementares no contexto do Sistema Único de Saúde, à luz da concepção de Bioética da Proteção. Trata-se de revisão integrativa da literatura com recorte temporal de 2007 a 2017, cuja busca do material ocorreu no mês de abril de 2018, na Biblioteca Virtual em Saúde. Como resultado, foi identificado que a maior parte do material analisado é recente, entre 2010 e 2017, escrita por diferentes profissionais que se preocupam em estudar o tema, em periódicos de nível nacional no idioma português, sendo o interesse predominante entre farmacêuticos e enfermeiros. Foi possível perceber que, na concepção dos usuários, as Práticas Integrativas Complementares investigadas influenciam positivamente na autonomia do usuário. Embora as Práticas Integrativas Complementares sejam consideradas estratégias eficazes na promoção da saúde, surgem desafios ao integrá-las em um contexto onde a biociência domina nos aspectos epistemológicos e culturais. Recomenda-se, assim, que se ampliem as pesquisas sobre Prática Integrativa Complementar, e se invista em metodologias para a sensibilização dos atores envolvidos, visando ampliar a interface com a promoção da saúde, favorecendo a compreensão e a consolidação dessas práticas no cenário do fazer em saúde.
KTSP TRANSITION TOWARDS 2013 CURRICULUM AT JUNIOR HIGH SCHOOL OF TAMAN DEWASA IBU PAWIYATAN TAMANSISWA, YOGYAKARTA
Authors: Husna US Atik Nidaul , Wijayanti Wiwik 
Published: July 2020

All of schools policy will surely reap different reactions. 2013 curriculum which was allegedly reformer of KTSP is now a big question about the success of its implementation. This study aims to describe the process of implementing the curriculum 2013 transition at Junior High School of Taman Dewasa Ibu Pawiyatan Tamansiswa, Yogyakarta. The method of this study was qualitative with the type of case study approach. The results of this study indicate that (1). Curriculum planning involves all relevant stakeholders, including: the principal, deputy head of curriculum, deputy head of students’ affairs, deputy head of facilities and infrastructure, teacher teams and school committees. (2). The implementation of the curriculum was carried out in stages. Starting with applying the 2 013 curriculum in grades 7 and 8, meanwhile grade 9 still uses the KTSP. (3). Evaluation of curriculum has two categories of assessment that come from internal and external schools. The results describe that 2013 curriculum can be implemented gradually well. The conclusion is transition from KTSP to 2013 curriculum gradually. In the near future, the school will implement the 2013 curriculum thoroughly in every class without leaving the school’s specificity with the values of art, culture and character.
Mondialisation et violence sexiste
Authors: Moffette David 
Published: July 2020

Plusieurs indices laisse supposer l’existence d’un lien entre avancée de la mondialisation capitaliste et augmentation de la violence sexiste. Cet article contribue à la réflexion sur le sujet en présentant le cas des travailleuses domestiques migrantes au Canada. L’auteur suggère que l’augmentation des inégalités économiques et sociales liées à la mondialisation affecte particulièrement les individus appauvris et les femmes. Dans ce contexte, plusieurs femmes migrent pour travailler dans des conditions précaires, s’exposant ainsi à diverses formes de violence. Présentant la situation de travailleuses migrantes inscrites au « Programme concernant les aides familiaux résidants » (PAFR) du gouvernement canadien, l’auteur soutient que leurs conditions de travail relève de ce qu’il convient d’appeler la « traite de femmes ».
Az egészséges táplálkozás fogyasztói megítélése – Egy feltáró kutatás eredményei
Authors: Farkas Noémi Dóra , Kiss Marietta 
Published: July 2020

Jelen kutatás legfőbb célkitűzése az volt, hogy feltárja a debreceni, vagy Debrecenben élő fogyasztók attitűdjeit az egészséges táplálkozással kapcsolatban, illetve az egészséges táplálkozás kivitelezhetőségét mindennapi életükben. A primer adatgyűjtés módszere a fókuszcsoportos interjú volt, két fókuszcsoportban eltérő (egészségpreventív és egészségrizikó) egészségmagatartással rendelkező, Debrecenben élő fogyasztók vettek részt. A két csoport eredményei rendkívül jól tükrözik, hogy a különböző egészségmagatartást mutató fogyasztók milyen eltérő véleménnyel rendelkeznek azonos kérdésekben. Az egészségpreventív csoport tagjai szerint az egészséges táplálkozás nagy szerepet játszik az egészségmegőrzésben és segít fenntartani testi, lelki jólétünket. Ezen csoport tagjairól elmondható, hogy igen tudatosak, ha az egészségük megőrzéséről van szó. Lehetőség szerint változatosan étkeznek, különös figyelmet fordítva az élelmiszerek összetételére, minőségére és frissességére, rendszeresen végeznek valamilyen sporttevékenységet és kerülik az egészségre ártalmas viselkedésformákat. Ezzel szemben az egészségrizikó magatartású fogyasztók úgy vélik, hogy az egészséges táplálkozás drága és rendkívül körülményes, mind a beszerzést, mind az elkészítést illetően. Emellett – habár elismerik, hogy szerepe egyre inkább felértékelődik és a médiában is egyre nagyobb figyelmet kap – szerintük ezt a fajta táplálkozást manapság szinte lehetetlen kivitelezni. Jelen kutatás korlátja, hogy feltáró jellegű, ennek megfelelően kismintás fókuszcsoportos vizsgálat történt, amely kvalitatív információkat szolgáltatott. Így az eredmények nem általánosíthatók a teljes sokaságra, viszont jól megalapoznak további jövőbeli kvantitatív vizsgálatokat, melynek során a feltárt összefüggéseket kérdőív segítségével lehet majd számszerűsíteni.
JEL besorolás: I12, M31
Relationship between Plasma Lipidomics and Carotid Atherosclerotic Plaque
Authors: Xie Gaoqiang , Myint Phyo Kyaw , Fang Zhongze , Yang Ying , Ma Wenyao , Huo Yong , Gao Wei , Wu Yangfeng 
Published: July 2020

Abstract
Background: The rapidly growing discipline of lipidomics allows the study of a wide spectrum of lipid species in human plasma and provides new insights into the pathogenesis of atherosclerosis. Objective: To explore the roles of plasma lipid components in relation to atherosclerotic plaques.Methods: Ten non-symptomatic persons (age 62.42±3.45) with 2 or more carotid plaques (soft or mixed) and ten apparently healthy controls without any carotid plaque (age 62.82±4.38), were randomly selected as cases and controls from a community-based sample of 1312 persons. Ultra-performance liquid chromatography coupled with electrospray ionization quadrupole mass spectrometry (UPLC-ESI-QTOF MS)-based lipidomics was used to measure lipid components. The difference of lipid species between cases and controls was analyzed by t-test and general linear regression. Results: Among 53 lipid components, significantly elevated plasma levels of one novel individual ceramide species (ceramide 22: 0) were observed in cases compared to the controls (0.59±0.18 versus 0.41±0.10μg/mL, p values<0.05). After adjusting for confounding factors, such as total cholesterol and low-density lipoprotein cholesterol, the results remained significant (p<0.05). 22:0 ceramide was significantly negatively correlated with vegetable intake (r=-0.74, p=0.014).Conclusion: High level of plasma ceramide 22:0 may be a novel risk factor for carotid atherosclerosis in human which independent of cholesterol and low-density lipoprotein cholesterol, it deserves future studies with larger sample size to confirm.
Fault Instability in a Geothermal Reservoir Facilitated by Low-grade Metamorphism
Authors: An Mengke , Zhang Fengshou , Min Ki-Bok , Elsworth Derek , Marone Chris 
Published: July 2020

Abstract
Occurrence of earthquakes related with geothermal reservoirs highlights the possibility that subsurface fluid injection may reactivate critically stressed faults and trigger seismicity. We report on laboratory experiments conducted at T = 100-250 °C, σc = 110 MPa and Pf = 42-63 MPa and show that two prevalent minerals, epidote and chlorite, impact frictional properties and fault stability under conditions relevant to typical geothermal reservoirs. Numerous geothermal reservoirs worldwide exhibit metamorphic epidotization and chloritization. Shear experiments on simulated epidote-rich fault gouges indicate potentially unstable frictional behavior - more pronounced at elevated temperatures and pore pressures. Increased proportions of chlorite in fault gouges stabilize the faults, which indicates that gouge composition exerts significant control on fault stability. Our results imply a high potential for induced seismicity on faults containing epidote found in many geothermal reservoirs.
Prevalence of Peripheral Neuropathic Pain among Adult Diabetic Patients (T2DM) with Peripheral Neuropathy and Quality of Life of the Patients with Peripheral Neuropathic Pain
Authors: Abu-Shennar Jawad AHMAD , Bayraktar Nurhan Bayraktar , Bebis Hatice Bebis 
Published: July 2020

Abstract
Aims: This study aims to assess the prevalence and characteristics of diabetic peripheral neuropathic pain (DPNP) among adult type 2 diabetes mellitus (T2DM) patients with diabetic peripheral neuropathy (DPN ) and to determine the effects of DPNP on their quality of life (QoL).Materials and methods: A cross-sectional study was conducted at the Jordanian Ministry of Health in Amman, Jordan during the period from the 15th of June 2019 to the 5th of October 2019. A total of 400 adult T2DM patients with DNP were recruited. Data were collected through a structured interview questionnaire and face- to- face interview. The DPNP was assessed using the translated version of Douleur Neuropathique4 (DN4), Besides, using the quality of life questionnaire entitled ( EQ-5D ) and Numeric Pain Rating Scale ( NRS ). Descriptive and inferential statistics were used for data analysis.Results: The overall prevalence of DPNP based on DN4 was 47.8%, more than half of the participants 50.3% were having mild pain, 45% were having moderate pain and 4.7% were having severe pain. The participants who have DPNP reported having problems in mobility, self-care, usual activity, and anxiety were reported in (r = 0.606) moderate (50-69). Logistic regression analysis revealed that patients with an HbA1c ≥7% were predictors to the increases/develop incidence of DPNP in adult T2DM patients with DPN. Conclusion: The study showed a high prevalence of DPNP among adult T2DM patients with DPN. Early detection and intervention are important for DPNP patients. Moreover, efforts should be made by the health care provider to prevent the occurrence of DPNP using initial measures such as glycemic control.
Shape and Position Design of Two-Step Micro-Channel on Plate During Rubber Pad Forming Process Based on Simulation
Authors: Teng Fei , Wang Hongyu , Wang Guodong , Jiang Lei , Li Jirui , Shi Shengnan , Sun Juncai , Sun Jie 
Published: July 2020

Abstract
Rubber pad forming is an advanced processing technology. The micro-channel is formed on the plate by both rubber pad and the metal mold. With the development of micro-channel, a two-step micro-channel has been applied in more and more fields. However, little attention was given to the geometric design and forming process of this unique channel. In this paper, the process of forming multi-row two-step micro-channels on plate by rubber pad forming is studied. At the same time, the length, width, height ratio and the edge chamfer of two-step micro-channel are discussed as the main parameters of geometry. The number and distance of the second-step structures are also studied in this paper. The influence of these geometric parameters on the forming results is analyzed in the finite element simulation. The plates are designed according to these geometric parameters and structures. Moreover, a novel shape and position design of two-step micro-channel are provided. In addition, forming experiments are also carried out for further study. Finally, a design strategy is provided by forming results in conclusions.
Co-designing a Self-Management App Prototype to Support People With Spinal Cord Injury in the Prevention of Pressure Injuries: Mixed Methods Study
Authors: Amann Julia , Fiordelli Maddalena , Brach Mirjam , Bertschy Sue , Scheel-Sailer Anke , Rubinelli Sara 
Published: July 2020

BackgroundSpinal cord injury is a complex chronic health condition that requires individuals to actively self-manage. Therefore, an evidence-based, self-management app would be of value to support individuals with spinal cord injury in the prevention of pressure injuries.ObjectiveThe main objectives of this study were to (1) establish a co-design approach for developing a high-fidelity prototype app for the self-management of individuals with spinal cord injury, (2) design the prototype that resulted from this process, and (3) conduct the first usability assessment of the prototype app.MethodsWe adopted a co-design approach to develop an evidence-based app prototype. Starting from a preliminary content model (based on clinical guidelines for the prevention of pressure injuries) and three research-based user personas, we conducted an ideation workshop involving individuals with spinal cord injury and health care professionals. The ideation workshop formed the basis for two consecutive design sprints. The result of this co-design phase was an interactive app prototype. The prototype was evaluated in two rounds of usability testing (N=4 and N=15, respectively) using a combination of qualitative and quantitative methods.ResultsThe co-design process resulted in a high-fidelity prototype with two key components: a self-management component and a communication component. The final prototype included a combination of features to support individuals with spinal cord injury in the prevention of pressure injuries, namely a smart camera, pressure injury diary, expert consultation, reminders, and knowledge repository. Findings of the usability testing showed that most participants navigated the app fluently with little back and forth navigation and were able to successfully complete a set of assigned tasks. These positive results are supported by the average system usability score achieved (78.5/100; range 47.5-95.0) and our qualitative analysis of the semistructured interviews. Despite an overall positive evaluation of the app prototype, we identified areas for improvement (eg, inclusion of a search function).ConclusionsIndividuals with spinal cord injury often need to navigate competing interests and priorities, paired with uncertainty about the accuracy and relevance of clinical recommendations. Understanding what matters to individuals with spinal cord injury can help guide the design of behavioral interventions that are useful and acceptable to these individuals in their daily lives. This study shows that involving individuals with spinal cord injury and health care professionals in co-designing a self-management app can foster knowledge cocreation at the intersection of lived experience, medical expertise, and technical solutions.
Causal Effect of Honorary Titles on Physicians’ Service Volumes in Online Health Communities: Retrospective Study
Authors: Yu Haiyan , Wang Yali , Wang Jying-Nan , Chiu Ya-Ling , Qiu Hang , Gao Mingyue 
Published: July 2020

Background
An OHC online health community (OHC) is an interactive platform for virtual communication between patients and physicians. Patients can typically search, seek, and share their experience and rate physicians, who may be involved in giving advice. Some OHC providers provide incentives in form of honorary titles to encourage the web-based involvement of physicians, but it is unclear whether the award of honorary titles has an impact on their consultation volume in an OHC.

Objective
This study is designed to identify the differential treatment effect of the incentive policy on the service volumes for the subgroups of treatment and control in an OHC. This study aims to answer the following questions: Does an honorary title for physicians impact their service volumes in an OHC? During the period of discontinuity, can we identify the sharp effect of the incentive award on the outcomes of physicians’ service volumes?

Methods
We acquired the targeted samples based on treatment, namely, physicians with an honorary title or not and outcomes measured before and after the award of the 2 subgroups. A regression discontinuity design was applied to investigate the impact of the honorary titles incentive as a treatment in an OHC. There was a sharply discontinuous effect of treatment on physicians’ online health service performance. The experimental data set consisted of 346 physicians in the treatment group (with honorary titles). Applying the propensity score matching method, the same size of physicians (n=346) was matched and selected as the control group.

Results
A sharp discontinuity was found at the time of the physician receiving the honorary title. The results showed that the parametric estimates of the coefficient were significantly positively (P<.001) associated with monthly home page views. The jump in the monthly volumes of home page views was much sharper than that of the monthly consultations.

Conclusions
The changes in the volumes of monthly consultations and home page views reflect the differential treatment effect of honorary titles on physicians’ service volumes. The effect of the incentive policy with honorary titles is objectively estimated from both the perspective of online and offline medical services in an OHC. Being named with honorary titles significantly multiplied monthly home page views, yet it did not significantly impact monthly consultations. This may be because consultation capacity is limited by the physician's schedule for consultations.
Pengaruh Kualitas Produk dan Persepsi Harga Terhadap Kepuasan Konsumen Studio Fotografi Calista Yogyakarta
Authors: Retno Dwi 
Published: July 2020

ABSTRAKPenelitian ini bertujuan untuk menguji pengaruh kualitas produk dan persepsi harga terhadap kepuasan konsumen studio Calista Yogyakarta. Penelitian ini dilakukan di studio Calista Kota Yogyakarta dengan menyurvei 100 responden. Teknik pengambilan sampel dengan metode survei, menggunakan kuesioner dengan teknik. Metode analisis menggunakan analisis regresi berganda. Hasil penelitian ini, menemukan adanya pengaruh positif dan signifikan antara kualitas produk dan persepsi harga terhadap kepuasan konsumen. Kualitas poduk berpengaruh terhadap kepuasan konsumen dengan tingkat kepuasan 10,568 dengan signifikan sebesar 0,000 kurang dari 5% (0,0000,050). Persepsi harga tidak signifikan karena, apabila suatu produk memiliki kualitas bagus maka secara langsung konsumen tidak mempermasalahkan harga dan tidak memengaruhi kepuasan konsumen. ABSTRACT This study aims to examine the effect of product quality and price perceptions on consumer satisfaction at the Yogyakarta Calista studio. This research was conducted in the Calista studio of Yogyakarta City by surveying 100 respondents. The sampling technique using the survey method, using a questionnaire with techniques. The method of analysis uses multiple regression analysis. The results of this study found a positive and significant effect between product quality and price perception on consumer satisfaction. Product quality has an effect on consumer satisfaction with a level of satisfaction of 10,568 with a significance of 0,000 less than 5% (0,0000,050). Perception of the price is not significant because if the product has a price issue and does not affect customer satisfaction. Good quality, then directly consumers are not.
HAK KOMUNAL ATAS TANAH SEBAGAI HAK ATAS TANAH DESA PAKRAMAN DI BALI
Authors: Cahyadi Wiguna Made Oka 
Published: July 2020

The government has indeed provided legal protection and certainty to indigenous peoples regarding their ulayat lands, through a Ministerial Regulation. However, it needs to be studied more deeply about the concept of communal rights to land and Pakraman village as the subject of communal rights holders on land. Communal rights to land are conceptualized as models of land rights that have just been raised in the national land law system. The consequence is that indigenous and tribal peoples as communal rights holders are authorized to use and benefit from their communal land. Pakraman village qualifies as a subject of communal rights to land because Pakraman village in Bali is classified into the community of the community, has a system of customary government referred to as the traditional prajuru led by a customary village leader. Then Pakraman village has a legal area called the Palemahan Pakraman village. As an instrument that regulates the life and social interaction of the community, awig-awig is the customary law of the community in a Pakraman village in Bali.