bluuebunny/crossref_metadata_2025_split huggingface dataset:
Competency Alignment and Certification for Preservice Home Visitors
Authors: Walsh Bridget A. , Mortensen Jennifer A. , Peterson Carla A. , Cassidy Dawn ,   Collaborative for Understanding the Pedagogy of Infant/Toddler Development (CUPID)
Published: December 2019

ObjectiveTo explore home visitor expanded competencies aligned with family life education (FLE) competencies to inform the knowledge, skills, and attitudes addressed in preservice home visitor training.BackgroundHome visitor preparation in higher education should be informed by widely accepted competencies.MethodWe aligned FLE competencies with the Collaborative for Understanding the Pedagogy of Infant/Toddler Development (CUPID) competencies into a framework of knowledge, skills, and attitudes to promote practices in the field while preparing to earn the Certified Family Life Educator (CFLE) credential. This framework was developed through an iterative process with stakeholders.ResultsThe full alignment includes 10 competencies.ImplicationsThis comprehensive alignment may inform the scholarship of teaching and learning in home visiting coursework and FLE content area coursework. This alignment may also promote developing new courses on home visiting, enhancing existing courses to address home visiting competencies, or modifying existing pedagogy. In the future, National Council on Family Relations CFLE‐approved programs may want to incorporate the content of this alignment into their courses to promote the ability of preservice home visitors to apply for the CFLE credential.
Crystal structures and calorimetry reveal catalytically relevant binding mode of coproporphyrin and coproheme in coproporphyrin ferrochelatase
Authors: Hofbauer Stefan , Helm Johannes , Obinger Christian , Djinović‐Carugo Kristina , Furtmüller Paul G. 
Published: December 2019

Coproporphyrin ferrochelatases (CpfCs, EC 4.99.1.9) insert ferrous iron into coproporphyrin III yielding coproheme. CpfCs are utilized by prokaryotic, mainly monoderm (Gram‐positive) bacteria within the recently detected coproporphyrin‐dependent (CPD) heme biosynthesis pathway. Here, we present a comprehensive study on CpfC from Listeria monocytogenes (LmCpfC) including the first crystal structure of a coproheme‐bound CpfC. Comparison of crystal structures of apo‐LmCpfC and coproheme‐LmCpfC allowed identification of structural rearrangements and of amino acids involved in tetrapyrrole macrocycle and Fe2+ binding. Differential scanning calorimetry of apo‐, coproporphyrin III‐, and coproheme‐LmCpfC underline the pronounced noncovalent interaction of both coproporphyrin and coproheme with the protein (ΔTm = 11 °C compared to apo‐LmCpfC), which includes the propionates (p2, p4, p6, p7) and the amino acids Arg29, Arg45, Tyr46, Ser53, and Tyr124. Furthermore, the thermodynamics and kinetics of coproporphyrin III and coproheme binding to apo‐LmCpfC is presented as well as the kinetics of insertion of ferrous iron into coproporphyrin III‐LmCpfC that immediately leads to formation of ferric coproheme‐LmCpfC (kcat/KM = 4.7 × 105 m−1·s−1). We compare the crystal structure of coproheme‐LmCpfC with available structures of CpfCs with artificial tetrapyrrole macrocycles and discuss our data on substrate binding, iron insertion and substrate release in the context of the CPD heme biosynthesis pathway.Enzyme
EC 4.99.1.9
Databasepdb‐codes of structural data in this work: 6RWV, 6SV3.
The IFITM protein family in adaptive immunity
Authors: Yánez Diana C. , Ross Susan , Crompton Tessa 
Published: December 2019

SummaryInterferon‐inducible transmembrane (IFITM) proteins are a family of small homologous proteins, localized in the plasma and endolysosomal membranes, which confer cellular resistance to many viruses. In addition, several distinct functions have been associated with different IFITM family members, including germ cell specification (IFITM1–IFITM3), osteoblast function and bone mineralization (IFITM5) and immune functions (IFITM1–3, IFITM6). IFITM1–3 are expressed by T cells and recent experiments have shown that the IFITM proteins are directly involved in adaptive immunity and that they regulate CD4+ T helper cell differentiation in a T‐cell‐intrinsic manner. Here we review the role of the IFITM proteins in T‐cell differentiation and function.
Conception narratives and third party reproduction in lesbian‐parented families in France
Authors: Gross Martine , Richardot Sophie 
Published: December 2019

AbstractLesbian mothers and gay fathers cannot conceal the existence of a third party for reproduction purposes: a sperm donor, an egg cell donor or a surrogate mother, all of whom have contributed, without being a parent as such, to the birth of their child. This article focuses on what is said about these third parties and what the child is told about his or her conception, by lesbian mothers who used sperm donation, either through the means of MAP or with the help of a known donor, outside the medical field. The inquiry, both qualitative and quantitative, uses a sample of 118 female couples to whom a child was born in France between 2011 and 2013. Analysis shows that the mothers employ different terms by which they wish to be known by their child and by which to refer to a donor according to whether he is known or not. The study exposes not only a common structure to most of the conception stories but also certain variations revealing four types of narratives. The narratives produced by couples who have used a known donor insist less on the love story between the two mothers. The entirety of these narratives, however, offer the chance to reconcile a transgressive family model with society: to normalise and valorise the family set‐up.
Revealing transactions data to third parties: Implications of privacy regimes for welfare in online markets
Authors: Baye Michael R. , Sappington David E. M. 
Published: December 2019

AbstractWe examine the effects of privacy policies regarding transactions (e.g., price/quantity) data on online shopping platforms. Disclosure of transactions data induces consumer signaling behavior that affects merchant pricing decisions and the welfare of platform participants. A profit‐maximizing platform prefers the disclosure policy that maximizes total welfare. Although this policy benefits sophisticated consumers, it harms unsophisticated (myopic) consumers. Consequently, the welfare effects of alternative privacy policies, data breaches, deceptive privacy policies, and opt‐in/opt‐out requirements can differ sharply, depending on the level of consumer sophistication and on other factors such as the prevailing status quo.
Physical and mechanical properties of three varieties of cucumber: A mathematical modeling
Authors: Moradi Mehdi , Balanian Hossein , Taherian Arian , Mousavi Khaneghah Amin 
Published: December 2019

AbstractThe current investigation was devoted to determining some properties, such as physical dimensions, surface area, sphericity, density, stiffness, and terminal velocity of cucumber. For this purpose, different cultivars of cucumber which commonly consumed in Iran, namely, Nagin, Shahab, and Shahin were selected. Also, in order to propose a new model for the terminal velocity of cucumber, a dimensionless model was established. The obtained results showed that varieties of Shahab, Shahin, and Nagin had an average length of 163.4, 118.97, and 133.89 mm, respectively. Corresponding values for average diameter for varieties mentioned earlier were measured as 26.99, 57.811, and 27.59 mm, respectively. Moreover, the density determined from the measurement of mass and volume for Shahab, Shahin, and Nagin varieties were calculated as 956, 1042, and 990 kg m−3, respectively, while the compressive and shear bio‐yield point of them were reported as 628.38 and 74.094, 505.11 and 89.33, and 652.2 and 64.79 N, respectively. Additionally, the assessment of the dimensionless model, regarding the coefficient, mean relative deviation, and root means the square error of comparison between predicted and measured terminal velocity were 0.9, 0.15, and 0.013, respectively. Therefore, the obtained characteristics may be useful in the design of different unit operations of post‐harvesting technologies.Practical applicationsMeasurement of physical properties of different common cucumber fruits can be accounted for as a useful tool to design the post‐harvesting unit operations. Therefore, the proposed mathematical model for the description of the terminal velocity of cucumber could be approached in pickle production units. Also, the obtained properties are usable in hydro transport and sorting of the fruit.
Quality issues identified in systematic reviews on platelet‐rich plasma therapy for pattern hair loss—A method study
Authors: Peinemann Frank , Dervishi Gezim 
Published: December 2019

AbstractBackgroundSystematic reviews of healthcare interventions aim to evaluate the quality of clinical studies, but they might have quality issues in their own right.ObjectiveWe aimed to evaluate methodological inconsistencies in systematic reviews.MethodsWe searched the database MEDLINE and included systematic reviews and/or meta‐analyses on platelet‐rich plasma therapy for pattern hair loss.ResultsWe identified 15 relevant systematic reviews and/or meta‐analyses, and we identified various overt methodological inconsistencies in five of those systematic reviews. These inconsistencies concerned including duplicate data, mixing data from various study designs, misclassifying study designs and treatment comparisons, misinterpreting heterogeneity, and mistaking reporting standards.ConclusionThe identification of various inconsistencies in previous systematic reviews on platelet‐rich plasma therapy for pattern hair loss should prompt future authors to consult the Cochrane Handbook and to implement the PRISMA statement.
Patients’ lived experiences of waiting for and undergoing endovascular aortic repair in a hybrid operating room: A qualitative study
Authors: Bazzi May , Lundèn Maud , Ahlberg Karin , Bergbom Ingegerd , Hellström Mikael , Lundgren Solveig M. , Fridh Isabell 
Published: December 2019

AbstractAims and objectivesThe overall aim of the study was to illuminate the patients’ lived experiences of waiting for and undergoing an endovascular aortic repair (EVAR) in a hybrid operating room (OR).BackgroundThe hybrid OR is an example of the technological advancements within hospitals. The environmental impact on humans is well recognised but is rarely taken into account when hospitals are designed or rebuilt. The patient's experience of a hybrid OR is not earlier described.DesignA qualitative design based on hermeneutic phenomenology was implemented.MethodsInterviews were conducted with 18 patients. A thematic interpretation based on van Manen's approach was then used to analyse the findings. The consolidated criteria for reporting qualitative studies (COREQ) were used (Data S1).ResultsThe following three themes emerged from the interviews: (a) being scheduled for surgery induced both anxiety and hopefulness; (b) feeling watched over and surrendering to others in the technology intense environment and (c) feeling relief but unexpected exhaustion after surgery. In the discussion, the results were additionally reflected upon out from the four lifeworld existentials: lived body, lived space, lived time and lived others.ConclusionsThe hybrid OR technology did not frighten the patients, but it was also not an environment that promoted or was conductive to having a dialogue with the staff. The disease and surgery brought feelings of anxiety, which was largely associated with the uncertainty of the situation. We suggest that continuity in contact with staff and patient‐centred information could be solutions to further calm the patients.Relevance to clinical practiceThe hybrid OR environment itself did not seem to frighten the patient, but the way the high‐tech environment increased the distance between the patient and the multiple staff members needs further investigation.
The ABA intervention for improving breastfeeding initiation and continuation: Feasibility study results
Authors: Clarke Joanne L. , Ingram Jenny , Johnson Debbie , Thomson Gill , Trickey Heather , Dombrowski Stephan U. , Sitch Alice , Dykes Fiona , Feltham Max , MacArthur Christine , Roberts Tracy , Hoddinott Pat , Jolly Kate 
Published: December 2019

AbstractThe UK has low breastfeeding rates, with socioeconomic disparities. The Assets‐based feeding help Before and After birth (ABA) intervention was designed to be inclusive and improve infant feeding behaviours. ABA is underpinned by the behaviour change wheel and offers an assets‐based approach focusing on positive capabilities of individuals and communities, including use of a Genogram. This study aimed to investigate feasibility of intervention delivery within a randomised controlled trial (RCT). Nulliparous women ≥16 years, (n = 103) from two English sites were recruited and randomised to either intervention or usual care. The intervention – delivered through face‐to‐face, telephone and text message by trained Infant Feeding Helpers (IFHs) – ran from 30‐weeks' gestation until 5‐months postnatal. Outcomes included recruitment rates and follow‐up at 3‐days, 8‐weeks and 6‐months postnatal, with collection of future full trial outcomes via questionnaires. A mixed‐methods process evaluation included qualitative interviews with 30 women, 13 IFHs and 17 maternity providers; IFH contact logs; and fidelity checking of antenatal contact recordings. This study successfully recruited women, including teenagers, from socioeconomically disadvantaged areas; postnatal follow‐up rates were 68.0%, 85.4% and 80.6% at 3‐days, 8‐weeks and 6‐months respectively. Breastfeeding at 8‐weeks was obtained for 95.1% using routine data for non‐responders. It was possible to recruit and train peer supporters to deliver the intervention with adequate fidelity. The ABA intervention was acceptable to women, IFHs and maternity services. There was minimal contamination and no evidence of intervention‐related harm. In conclusion, the intervention is feasible to deliver within an RCT, and a definitive trial required.
Investigating the root plasticity response of Centaurea jacea to soil water availability changes from isotopic analysis
Authors: Kühnhammer Kathrin , Kübert Angelika , Brüggemann Nicolas , Deseano Diaz Paulina , van Dusschoten Dagmar , Javaux Mathieu , Merz Steffen , Vereecken Harry , Dubbert Maren , Rothfuss Youri 
Published: December 2019

Summary

Root water uptake is a key ecohydrological process for which a physically based understanding has been developed in the past decades. However, due to methodological constraints, knowledge gaps remain about the plastic response of whole plant root systems to a rapidly changing environment.

We designed a laboratory system for nondestructive monitoring of stable isotopic composition in plant transpiration of a herbaceous species (Centaurea jacea) and of soil water across depths, taking advantage of newly developed in situ methods. Daily root water uptake profiles were obtained using a statistical Bayesian multisource mixing model.

Fast shifts in the isotopic composition of both soil and transpiration water could be observed with the setup and translated into dynamic and pronounced shifts of the root water uptake profile, even in well watered conditions.

The incorporation of plant physiological and soil physical information into statistical modelling improved the model output. A simple exercise of water balance closure underlined the nonunique relationship between root water uptake profile on the one hand, and water content and root distribution profiles on the other, illustrating the continuous adaption of the plant water uptake as a function of its root hydraulic architecture and soil water availability during the experiment.
Up‐regulation of plasma lncRNA CACS15 distinguished early‐stage oral squamous cell carcinoma patient
Authors: Zhang Xinyu , Guo Bing , Zhu Yun , Xu Wanlin , Ning Shangbo , Liu Liu 
Published: December 2019

AbstractObjectiveTo study the role of LncRNA CASC15 in oral squamous cell carcinoma.ResultsIn the present study, we showed that plasma CASC15 was up‐regulated in stage I and II oral squamous cell carcinoma patients than in oral ulcer patients and healthy controls, while no significant correlation was found between oral ulcer patients and healthy controls. Up‐regulation of plasma CASC15 distinguished oral squamous cell carcinoma patients from oral ulcer patients and healthy controls. LncRNA MEG3 was inversely correlated with CASC15 in oral squamous cell carcinoma tissues. In oral squamous cell carcinoma cells, CASC15 over‐expression led to the inhibited expression of MEG3, and MEG3 over‐expression did not alter CASC15 expression. MEG3 over‐expression decreased, while CASC15 over‐expression increased the proliferation rate of oral squamous cell carcinoma cells. In addition, MEG3 over‐expression attenuated the effects of CASC15 over‐expression.ConclusionTherefore, CASC15 over‐expression may serve as a potential diagnostic biomarker for oral squamous cell carcinoma, and CASC15 may promote oral squamous cell carcinoma cell proliferation by down‐regulating MEG3.
Treatment of nitric oxide supplemented with nitrogen and sulfur regulates photosynthetic performance and stomatal behavior in mustard under salt stress
Authors: Jahan Badar , AlAjmi Mohamed F. , Rehman Md Tabish , Khan Nafees A. 
Published: December 2019

Nitric oxide (NO) is a hormone that connects numerous reactions in plant cells under normal and environmental stress conditions. The application of 100 µM NO as sodium nitroprusside (SNP; NO donor) applied individually or in combination with  N or  S in different combinations (i.e. 100 mg N or S kg−1 soil applied at the time of sowing [100 N + 100S]0d or with split, 50 mg N or S kg−1 soil at the time of sowing and similar dose at 20 d after sowing [50 N + 50S]0d + [50 N + 50S]20d) was tested to alleviate salt stress in mustard (Brassica juncea L.). Application of 100 µM NO plus split application of N and S more significantly promoted stomatal behavior, photosynthetic and growth performance in the absence of salt stress and maximally alleviated effects of salt stress through increased N‐ and S‐use efficiency, proline and antioxidant system. The combined application of N and S at the time of sowing was lesser effective in promoting photosynthesis and growth under salt or no salt stress conditions in presence or absence of NO. The study suggests that salt stress effects on the photosynthetic performance are mitigated more efficiently when NO was applied together with the split application of N and S given at two stages, and the photosynthetic activity was promoted under salt stress through increased N and S assimilation and antioxidant system. This strategy may be adopted in agricultural system for overcoming salt stress effects on performance of mustard.
Chronology and sequence of deciduous teeth eruption in children with microcephaly associated to the Zika virus
Authors: D'Agostino Érica Santana , Chagas Janeusa Rita Leite Primo , Cangussu Maria Cristina Teixeira , Vianna Maria Isabel Pereira 
Published: December 2019

AbstractIntroductionDeciduous teeth eruption is connected to children's growth and development. In Brazil, with the increase in the occurrence of children born with microcephaly associated to exposure to Zika virus, studies about orofacial alterations were necessary.ObjectiveDescribe the chronology and sequence of deciduous teeth in children with microcephaly due to the fetal exposure to Zika virus.MethodologyA cross‐sectional study involving 74 children of a neuropediatric reference unit in Salvador, Bahia, in 2017 was conducted. Through use of secondary data, interviews with mothers and children's exam, the population was characterized, the chronology and sequence of deciduous teeth eruption was registered, and the analysis of the variables was proceeded.ResultsThe first eruption happened between 4 and 17 months of age and 52.70% had a delay in the eruption of incisors. The average eruption time for the maxilla varies from 17.92 (16.56‐19.28; 95% CI) to 20.43 (19.35‐21.51; 95% CI) months, and the jaw from 11.57 (6.85‐18.99; 95% CI) to 20.20 (19.09‐21.31; 95% CI) months. In 77.94% of population, the eruption of the first teeth was in the lower arch and in 33.82%, molars and/or canines erupted before the incisors.ConclusionsThere were alteration in the chronology and sequence of deciduous teeth eruption.
Optical coherence tomographic (OCT) evaluation of intraoral non‐ablative erbium: YAG laser (SMOOTH mode) in rejuvenation of nasolabial folds; A prospective randomized split face comparative pilot study
Authors: Moftah Nayera , Samy Nevien , Allam Riham S. H. M. , El Tagy Shaza A. H. , Abdelghani Rania 
Published: December 2019

AbstractBackgroundThere are both few non‐comparative studies investigating the efficacy of intraoral Er: YAG laser (SMOOTH mode) in rejuvenating nasolabial folds (NLFs) and lack of valid and objective wrinkles scales. In this prospective randomized split face comparative pilot study, we investigated the safety and efficacy of intraoral Er: YAG laser (SMOOTH MODE) compared with extraoral approach in rejuvenating NLFs using OCT as an objective evaluating tool.Materials and MethodsTwenty adult women with notable NLFs were randomized in this study. The patients received 5 monthly sessions of Er: YAG laser (SMOOTH mode) using intraoral approach on one side and extraoral approach on the other side. Outcome was evaluated 2 weeks and 4 months post‐treatment by Global Aesthetic Improvement Scale (GAIS), OCT, and patients’ satisfaction. Side effects were also evaluated.ResultsIntraoral sides had significant increase in OCT evaluated dermal thickness at 4 months post‐treatment (P = .03) without side effects compared with extraoral sides. Extraoral approach had significantly higher patients’ satisfaction compared with intraoral approach at 2 weeks and 4 months post‐treatment (P = .03, .02, respectively). Insignificant differences between both approaches were found regarding GAIS scoring, OCT evaluated epidermal thickness at 2 weeks and 4 months post‐treatment, and OCT evaluated dermal thickness at 2 weeks post‐treatment (P < .05).ConclusionIntraoral Er: YAG laser (SMOOTH mode) is safer and more effective than extraoral approach in rejuvenating NLFs. OCT is a promising objective tool for evaluating facial wrinkles. Further studies are still needed.
Mantle resistance against Gibraltar slab dragging as a key cause of the Messinian Salinity Crisis
Authors: Capella Walter , Spakman Wim , van Hinsbergen Douwe J. J. , Chertova Mariya V. , Krijgsman Wout 
Published: December 2019

AbstractThe Messinian Salinity Crisis (5.97–5.33 Ma) was caused by the closure of the Atlantic‐Mediterranean gateways that cut through the Gibraltar orogenic system. The geodynamic drivers underlying gateway closure and re‐opening are still debated. Here, we interrogate the gateway successions to find the imprints of surface deformation, infer the timing and nature of associated geodynamic drivers, and test such inferences against numerical simulations of slab dynamics. We find that since the latest Miocene, a tectonic framework was established in the gateway region dominated simultaneously by (a) relative plate convergence, (b) slab tearing under the eastern Betic Cordillera and (c) mantle resistance against north‐northeastward dragging of the Gibraltar slab by the African plate's absolute motion. We propose that mantle‐resisted slab dragging and slab tearing operated in concert closing the gateways that caused the Messinian Salinity Crisis, whereas sinking of heavy oceanic lithosphere located between buoyant continental plates re‐opened the Strait of Gibraltar at 5.33 Ma.