bluuebunny/crossref_metadata_2025_split huggingface dataset:
RELATIVE POTENCY OF ANTI-DIABETIC COSTUS SPECIOSUSPLANT EXTRACT IN MOUSE FIBROBLAST CELL LINE
Authors: Bindu  , Bhat Rama , Girish  , Prasad Krishna 
Published: January 2021

Plant-derived compounds have been used clinically to treat type 2 diabetes for many years as they also exert additional beneficial effects on various other disorders. PI3K pathway is the major pathway activated by insulin receptor (IR). It induces glucose uptake, glycogen synthesis, protein synthesis, cell growth and differentiation. Hence metabolic assay was employed to assess glucose uptake based on the property of 3T3-L 1 cells to differentiate into adipocytes which can take up the glucose in medium due to the effect of insulin or insulin like molecules. The results of the current study showed that plants extract probably exerts its anti-diabetic properties by stimulating glucose uptake in adipocytes with significant inhibition of adipogenesis demonstrating reliable relative potency in comparision to the commercial insulin. The ability of existing therapies to target various aspects of the insulin resistance syndrome induces other metabolic abnormalities, chiefly those involved in lipid metabolism.
In this preliminary in-vitro study Costusspeciosus plant extract demonstrated to have significant relative potency in comparison to commercial Insulin which can be exploited to treat diabetes using natural herbal extracts
Current study leads researchers to elucidate the chemical structures, isolate active ingrediatents in the crude extract for such biological activities in reference to commercial and recombinant insulins.
Perbaikan Stabilitas Dinamik Sistem Tenaga Terintegrasi Pembangkit Listrik Tenaga Mikro Hidro dan Diesel Menggunakan PSS Berbasis ANFIS
Authors: Ginarsa I Made , Nrartha I Made Ari , Sultan Sultan , Muljono Agung Budi , Nababan Sabar 
Published: January 2021

Power generating units should be built closed to load centers according to electric power company regulation. These units are generally small in capacity, so that makes power transfer among inter- and outer-areas is easier to be done. This study aims to improve dynamic stability of a Micro Hydro Power Plant (MHPP) on perspective of 5% load increased in Diesel Power Plant (DPP). The DPP is equipped by an ANFIS-based Power System Stabilizer (PSS) in this scheme. Two inputs with Gauss2mf membership function (MF) type and 5-number of the each MF are used to implement the ANFIS model. Simulation results show that overshoot of MHPP power angle deviation is reduced to the values of 0.023, 0.0138 and 0.0132°, for the DPP without PSS, conventional and ANFIS PSS, respectively. Also, reduction in setting time is achieved at times >6, 4.051 and 3.553 s. It is shown that the ANFIS PSS is more effective to enhance the dynamic stability compared to other PSS
Surgical Treatment Spine Tuberculosis by Decompression and Posterior Stabilization via Transpedicular Approach: a Retrospective Study
Authors: Rahim Agus Hadian , Ramdan Ahmad , Hadar Abdul Kadir , Silitonga Arnold David Pardamean , Sudjana Doddy Putra Pratama 
Published: January 2021

Clinical intervention has a central role in the outcome of spondylitis tuberculosis cases. Surgical procedures indicate to prevent neurological collapse, preservation of stability, and early mobilization. The study aims to analyze the outcome of surgical intervention in spinal tuberculosis by using a transpedicular approach. This research was a retrospective study on the Department of Orthopaedics and Traumatology in Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, during 2016–2018. There were 64 subjects in this study; 35 were male, and 29 were female, ages ranged 21–60 years with a follow-up period of 12 months to 18 months. A more common site of tubercular lesion was at the thoracal lesion (44%). In this research, the patients were preoperatively categorized by the American Spinal Injury Association (ASIA) Impairment Assessment. Among them four were ASIA-A, 10 were ASIA-B, 30 were ASIA-C, 15 were ASIA-D, and five were ASIA-E. After the operative procedure, two patients were ASIA-B, five patients were ASIA-C, 17 patients were ASIA-D, and 40 were ASIA-E. Maximum patients (62%) had bony fusion grade 1. Greater than 80% of subjects had a satisfactory result. In conclusion, posterior decompression and preservation of stability with transpedicular fusion are an excellent surgical way of posterior lumbar spinal tuberculosis treatment. TINDAKAN OPERASI DEKOMPRESI DAN STABILISASI POSTERIOR MELALUI PENDEKATAN TRANSPEDIKULAR PADA TUBERKULOSIS TULANG BELAKANG: STUDI RETROSPEKTIFTindakan medis berperan penting pada manajemen akhir kasus tuberkulosis tulang belakang. Prosedur operasi dilakukan untuk mencegah perburukan defisit neurologis, menjaga kestabilan tulang belakang, dan mobilisasi dini. Tujuan penelitian ini adalah menganalisis luaran hasil tindakan operatif pada tuberkulosis tulang belakang dengan pendekatan transpedikular. Penelitian ini merupakan studi retrospektif pada Departemen Orthopaedi dan Traumatologi RSUP Dr. Hasan Sadikin, Bandung, Indonesia, periode tahun 2016–2018. Terdapat 64 subjek dalam penelitian ini yang terdiri atas 35 laki-laki dan 29 perempuan, serta usia berkisar 21–60 tahun dengan masa tindak lanjut 12–18 bulan. Pada penelitian ini, lesi tuberkuler paling banyak terjadi di regio torakal (44%). Subjek penelitian dikategorikan menurut Impairment Assessment dari American Spinal Injury Association (ASIA). Preoperatif terdapat empat pasien ASIA-A, 10 pasien ASIA-B, 30 pasien ASIA-C, 15 pasien ASIA-D, dan lima pasien ASIA-E. Setelah tindakan operasi terdapat dua pasien ASIA-B, lima pasien ASIA-C, 17 pasien ASIA-D, dan 40 pasien ASIA-E. Mayoritas pasien memiliki fusi tulang grade 1 (62%). Lebih dari 80% subjek penelitian menyatakan puas setelah operasi dilakukan. Simpulan, tindakan operatif dekompresi dan stabilisasi dengan fusi transpedikular merupakan metode yang unggul dalam manajemen tuberkulosis tulang belakang.
Measuring Envy Level among Students of Faculty of Medicine
Authors: Nurhayati Eka , Fitriyana Susan , Indrasari Eva Rianti 
Published: January 2021

Envy is a negative emotion that painful and unpleasant, caused by feelings of inferiority when someone compared themselves to others. Envy is divided into benign and malicious envy. Benign envy could be leverage to motivate someone to improve themselves until they reach or even exceed the envied person’s level. In contrast, malicious is destructive that someone could do anything to pull the envied person down to the same level as themselves or even lower. This study aimed to measure benign and malicious envy among the students of the Faculty of Medicine Universitas Islam Bandung. It was a descriptive study involving 152 students. Measurement made using the Benign and Malicious Envy Scale (BeMaS), which uses 6 points Likert scale during November 2019. Data analysis using Microsoft Excel. The study results showed envy among the students dominated by positive or productive envy, the mean value for benign envy (4.57), and malicious envy (1.92). It showed that benign envy push students to be more competitive rather than destructive envy. The conclusion of this study that the level of envy students of the Faculty of Medicine Universitas Islam Bandung dominated by benign envy. The faculty is responsible for developing strategies to increase the benign envy level and control the malicious envy level. PENGUKURAN TINGKAT IRI PADA MAHASISWA SEBUAH FAKULTAS KEDOKTERANIri adalah emosi negatif menyakitkan dan tidak menyenangkan yang diakibatkan oleh perasaan inferior ketika membandingkan diri dengan orang lain. Iri terbagi atas benign envy dan malicious envy. Benign envy bersifat memotivasi seseorang untuk terus memperbaiki diri sampai mencapai bahkan melebihi apa yang dimiliki kompetitornya. Sebaliknya, malicious envy bersifat destruktif ketika seseorang berupaya untuk menarik kompetitornya ke level yang sama dengan dirinya atau bahkan lebih rendah. Penelitian ini bertujuan mengukur tingkat benign dan malicious envy pada mahasiswa Fakultas Kedokteran Universitas Islam Bandung. Penelitian ini merupakan penelitian deskriptif dengan melibatkan 152 mahasiswa sebagai subjek penelitian. Pengukuran dilakukan menggunakan Benign and Malicious Envy Scale (BeMaS) selama November 2019 menggunakan 6 poin skala Likert dan analisis data menggunakan Microsoft Excel. Hasil penelitian menunjukkan bahwa rerata benign envy (4,57) lebih tinggi dibanding dengan malicious envy (1,92). Hal ini menunjukkan bahwa iri yang bersifat positif atau produktif jauh lebih tinggi dibanding dengan nilai iri yang bersifat destruktif. Simpulan penelitian ini adalah bahwa tingkat iri pada mahasiswa Fakultas Kedokteran Universitas Islam Bandung lebih dominan pada benign envy dibanding dengan malicious envy. Tugas fakultas adalah mengembangkan strategi agar dapat meningkatkan nilai benign envy serta berupaya mengendalikan tingkat malicious envy.
Factors Affecting Surgical Waiting Time in Cancer Patients at Referral Hospitals of West Java Province
Authors: Susanti Yuli , Irasanti Siska Nia , Akbar Ieva Baniasih , Sukarya Wawang S. 
Published: January 2021

A challenge for hospitals in facing the high number of patient visits is to provide quality services. One of the vital services in dealing with patients, especially those who will have cancer surgery considering the high rate of mortality cancer, is an improvement in waiting time (WT). Waiting time for elective surgery is one indicator of service quality with a standard of ≤2 days. This research aimed to determine the average WT for surgery, influencing factors, and optimal queuing models. The method used was quantitative and qualitative methods applied to 207 samples with consecutive sampling at West Java Provincial Al-Ihsan Regional General Hospital Bandung from October to December 2016. The analysis used partial least squares (PLS). The results of the study showed that the average WT for surgery was 32 days. Factors that influence WT were inpatient rooms, number of medical personnel, condition of patients, and health insurance. The optimal queue model to reduce surgical waiting time are adding inpatient beds, oncologist doctor, and creating an online system for registration and confirmation of inpatient rooms and operating. FAKTOR YANG MEMENGARUHI WAKTU TUNGGU OPERASI PASIEN KANKER DI RUMAH SAKIT RUJUKAN JAWA BARATTantangan bagi rumah sakit dalam menghadapi jumlah kunjungan pasien yang tinggi adalah mampu memberikan pelayanan berkualitas. Salah satu pelayanan signifikan bagi pasien kanker yang akan menjalani operasi adalah perbaikan waktu tunggu karena mortalitas pasien kanker yang tinggi. Waktu tunggu operasi elektif merupakan salah satu indikator mutu pelayanan dengan standar ≤2 hari. Penelitian bertujuan mengetahui waktu tunggu operasi rerata, faktor yang memengaruhi, dan model antrean yang optimal. Metode yang digunakan adalah kuantitatif dan kualitatif yang diterapkan pada 207 sampel secara consecutive sampling di RSUD Al-Ihsan Provinsi Jawa Barat Bandung dari Oktober hingga Desember 2016. Analisis menggunakan partial least squares (PLS). Hasil penelitian menunjukkan bahwa waktu tunggu operasi rerata adalah 32 hari. Faktor yang berpengaruh terhadap waktu tunggu operasi adalah ruang rawat inap, jumlah tenaga medis, kondisi pasien, dan jaminan kesehatan. Model antrean yang optimal untuk menurunkan waktu tunggu operasi adalah penambahan tempat tidur rawat inap, penambahan dokter spesialis bedah onkologi, serta pembuatan sistem daring untuk pendaftaran dan konfirmasi kesiapan ruang rawat inap dan ruang operasi.
Probability of Hypertension in Advancing Ages of Women
Authors: Yulianto Fajar Awalia , Romadhona Nurul , Rosarianto Febyana , Rahmanda Vihannis , Barlian Salman , Tania Tresya Anggi , Gunawan Romy Reynaldi , Ul Haque Sumayya Nuri Fuadana Aulia , Nataputri Rifa , Amalia Aulia Nur , Maresta Paulina , Nugroho Haris 
Published: January 2021

Hypertension is a problem in Indonesia, with 34.1% prevalence. The number reflected the number of hypertensive patients in the 2016 clinic report of Pasirjambu Public Health Center as the most prominent non-communicable disease. This research aimed to discover the specific age of onset and risk factors of hypertension in the village where the health center located. A rapid survey collected the data in May 2017, where 210 women (representing their household) were chosen by randomization inside their respective clusters. Risk factors were analyzed by a robust and parsimonious logistic regression model along with probability count on age as the final prediction. The prevalence of hypertension was 59.5% (95%CI: 52.9, 66.2%). Risk factors for hypertension were age (OR=1.06, p=0.00), stress (OR=1.74, p=0.09) and family history (OR=1.99, p=0.03) but the protective factor was consumption frequency of salty food (OR=0.64, p=0.10). In conclusion, a woman would have a 42.9% chance (95%CI: 33.7, 52.1%) for having hypertension at 40 years old of age after adjusted by other risk factors. Despite only two modifiable risk factors that can be intervened with, it would be worth trying to decrease the pace of onset in hypertension and the prevalence. KEMUNGKINAN HIPERTENSI BERDASAR ATAS USIA PADA WANITAHipertensi merupakan sebuah masalah di Indonesia dengan prevalensi sebesar 34,1%, angka tersebut terlihat dalam laporan tahunan Puskesmas Pasirjambu sebagai penyakit tidak menular terbanyak di wilayah kerjanya. Tujuan penelitian ini adalah mengetahui usia munculnya hipertensi dan faktor risikonya. Pengumpulan data dilakukan melalui survei cepat di bulan Mei 2017, melibatkan 210 wanita yang mewakili rumah tangganya dipilih secara random. Faktor risiko dianalisis menggunakan regresi logistik dengan hasil akhir berupa prediksi kemungkinan. Hasil penelitian menunjukkan prevalensi hipertensi sebesar 59,5% (IK95%: 52,9; 66,2%). Usia (OR=1,06; p=0,00), stress (OR=1,74; p=0,09) dan riwayat hipertensi dalam keluarga (OR=1,99; p=0,03) menjadi faktor risiko, sedangkan frekuensi konsumsi makanan asin (OR=0,64; p=0,10) menjadi faktor protektif. Setelah adjusted terhadap variabel lain, kemungkinan untuk hipertensi seorang wanita usia 40 tahun sebesar 42,9% (IK95%: 33,7; 52,1%). Pencegahan untuk menurunkan prevalensi dan laju insidensi dapat dilakukan dalam usia tersebut walaupun hanya ada dua faktor risiko yang dapat dimodifikasi.
Pilot Study of Lung Function Improvement in Peak Expiratory Flow (PEF) Value Using Fish Oil Containing Omega-3 Therapy in Asthma
Authors: Lorensia Amelia , Suryadinata Rivan Virlando , Ratnasari Richa 
Published: January 2021

Fish oil contains omega-3 as an anti-inflammatory effect that can inhibit the production of arachidonic acid 5-lipoxygenase (ALOX5), an enzyme that aggravates the inflammation of the lungs that cause asthma. This study aims to determine the effect of omega-3 from fish oil on improving lung function with peak expiratory flow (PEF) value in patients with outpatient asthma in Surabaya. The research design used in this research is pre-post test design and lung function examination by using a peak flow meter. Then follow up every week for four weeks during the use of fish oil, and the results of his research were analyzed by t test. The study was conducted from April 2017 until January 2018 in Surabaya. The sample of the study was 27 adult asthma patients. The results showed that most of the study subjects had an increase in PEF value every week. Besides, there was a significant increase of PEF values gradually at T0 (before intervention) to T4 (intervention for four weeks), indicating an improved effect after the use of fish oil in a four-week study sample. In conclusion, fish oil containing omega-3 is effective in improving lung function in outpatient asthma patients. PILOT STUDI PERBAIKAN FUNGSI PARU MENURUT NILAI PEAK EXPIRATORY FLOW (PEF) MENGGUNAKAN TERAPI MINYAK IKAN MENGANDUNG OMEGA-3 PADA ASMAMinyak ikan mengandung omega-3 sebagai efek antiinflamasi yang dapat menghambat produksi asam arakidonat 5-lipoksigenase (ALOX5) merupakan enzim yang memperburuk peradangan paru yang menyebabkan asma. Penelitian ini bertujuan mengetahui pengaruh omega-3 dari minyak ikan terhadap perbaikan fungsi paru dengan nilai peak expiratory flow (PEF) pada pasien asma dewasa rawat jalan di Surabaya. Desain penelitian yang digunakan dalam penelitian ini adalah pre-post test dan pemeriksaan fungsi paru menggunakan peak flow meter. Kemudian dilakukan follow up setiap minggu selama empat minggu selama penggunaan minyak ikan dan hasilnya dianalisis dengan uji t. Penelitian dilakukan pada April 2017 hingga Januari 2018 di Surabaya. Sampel penelitian sebanyak 27 pasien asma dewasa. Hasil penelitian menunjukkan bahwa sebagian besar subjek penelitian mengalami peningkatan nilai PEF setiap minggunya. Selain itu, terdapat peningkatan signifikan nilai PEF secara bertahap pada T0 (sebelum intervensi) sampai T4 (intervensi selama empat minggu) yang menunjukkan efek membaik setelah penggunaan minyak ikan pada sampel penelitian selama empat minggu. Simpulan, minyak ikan yang mengandung omega-3 terbukti efektif dalam perbaikan fungsi paru pada pasien asma rawat jalan.
Soil-Transmitted Helminths Contamination on the Yard's Soil of the Public Elementary Schools in Bandung City
Authors: Astuti Ratna Dewi Indi , Ismawati Ismawati , Rathomi Hilmi Sulaiman 
Published: January 2021

Soil contamination by soil-transmitted helminths (STH) on the schoolyard can act as reservoir STH infection for students. The STH contamination on soil due to contamination of human and animal waste which was disposed of inappropriately. This study aimed to determine the presence of STH eggs in the yard's soil of public elementary schools in Bandung city. This research was an analytic observational study with a cross-sectional approach. This study's samples were 97 surface soil of the public elementary schoolyard in Bandung city, selected randomly. Microscopic identification is made for identifying the STH contamination on soil samples. STH contaminates about 66% yard's soil of public elementary schools in Bandung city. We identified larva nematode, Ascaris eggs, Trichuris eggs, Toxocara eggs, and Capillaria eggs. The most common STH we had found was larvae nematode (53%). There is a correlation between flood and human STH contamination on soil (p=0.015). We concluded that STH contaminates the yard's soil of the public elementary schools in Bandung city. The source of STH contamination is from human and animal waste. Flood has a role in spreading human waste on the soil. KONTAMINASI SOIL-TRANSMITTED HELMINTH PADA TANAH PEKARANGAN SEKOLAH DASAR NEGERI KOTA BANDUNGPencemaran tanah oleh soil-transmitted helminth (STH) di halaman sekolah dapat menjadi reservoir penularan STH bagi siswa. Pencemaran ini dapat terjadi akibat pengelolaan kotoran manusia dan hewan yang tidak tepat. Penelitian ini bertujuan mengetahui keberadaan telur STH di tanah pekarangan sekolah dasar negeri di Kota Bandung. Penelitian ini merupakan penelitian observasional analitik dengan pendekatan cross-sectional. Sampel penelitian berjumlah 97 tanah permukaan halaman sekolah dasar negeri di Kota Bandung yang dipilih secara acak. Identifikasi mikroskopis dilakukan untuk mengidentifikasi kontaminasi STH pada sampel tanah. Data banjir didapatkan dari wawancara dengan penduduk sekitar. Pencemaran STH terjadi pada 66% sampel. Kami mengidentifikasi larva nematoda, telur Ascaris, telur Trichuris, telur Toxocara, dan telur Capillaria. Jenis STH yang paling banyak ditemukan adalah larva nematoda (53%). Terdapat korelasi antara banjir dan pencemaran STH manusia di tanah (p=0,015). Kami menyimpulkan bahwa tanah pekarangan sekolah dasar negeri di Kota Bandung tercemar STH. Sumber pencemaran STH berasal dari kotoran manusia dan hewan. Banjir berperan dalam menyebarkan kotoran manusia di tanah.
Statistical Process Control Vibrasi Bearing untuk Identifikasi Degradasi
Authors: Desriawati Riyani , Darwis Sutawanir , Hajarisman Nusar , Suliadi Suliadi , Widodo Achmad 
Published: January 2021

Statistical Process Control (SPC) is usually applied to the production process of goods, with the aim of detecting the quality of a production item that is within or beyond the specified specifications. In this study, SPC was applied to the bearing vibration signal to detect the first observable defect on a machine that functions as part of a prognostic tool for maintenance decision making. The detection of damage and prognostic are two important aspects in machine maintenance based on current conditions or better known as Condition (data) Based Maintenance (CBM). This paper discusses the shewhart average level chart and adaptive shewhart average level chart to detect the first observable defect. The shewhart chart is built with two assumptions, i.e. that the data must vary randomly around an established mean and follows a normal distribution. However, the adaptive Shewhart chart there is no need for normal assumption. The exploration of our data shows that the assumption of normality is not fulfilled, so that the Shewhart average level chart is not implemented. The adaptive Shewhart chart shows that the warning line for bearing 1 amounted to 5.547 and 3.631, for bearing 2 amounted to 5.491 and 3.635, for bearing 3 amounted to 5.762 and 3, 573, for bearing 4 of 5.604 and 33.615. The action line for bearing 1 is 6.026 and 3.152, for bearing 2 is 5.955 and 3.171, for bearing 3 is 6.309 and 3.026, for bearing 4 is 6.101 and 3.118. The first observable defect was t = 81 for bearing 1, t = 146 for bearing 2, t = 40 for bearing 3 and t = 61 for bearing 4. The adaptive Shewart chart can be used as a toll to estimate the initiation of transition state from normal to degenerate.
Dampak Covid-19 Terhadap Harga Saham dan Kinerja Keuangan Perusahaan
Authors: Rahmani Annisa Nadiyah 
Published: January 2021

The purpose of this study to determine the impact of Covid-19 on stock prices and financial performance of companies on LQ-45 issuers listed on the IDX. This study examines the impact of Covid-19 on stock prices and financial performance before being exposed to Covid-19 for Q3 2019 and after being exposed to Covid-19 for Q1 2020. Stock prices are measured using closing stock prices and financial performance is measured using a ratio formula that is Return on Assets (ROA), Operating Profit Margin (OPM), and Net Profit Margin (NPM). This study uses a sample of LQ-45 companies that have published their financial statements on the Indonesia Stock Exchange (IDX). This research uses multiple linear regression methods using SPSS 25. The results of this study indicate that (a) Pandemic Covid-19 has an impact on stock prices and (b) Pandemic Covid-19 has an impact on financial performance.