bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gut Dysbiosis with Minimal Enteritis Induced by High Temperature and Humidity
Authors: Chen Song , Zheng Yuhua , Zhou Yiqing , Guo Weizhong , Tang Qin , Rong Guangli , Hu Weiwei , Tang Jianbang , Luo Huanhuan 
Published: December 2019

AbstractHigh temperature and humidity (HTH) can cause diarrhea owing to food and drinking water contamination. However, their direct effects on gut microbiota and gastrointestinal inflammation are unknown. This study aimed to investigate the effects of HTH and probiotics on the microbiome. Twenty-one male mice were randomly assigned to normal control (NC), HTH, and broad-spectrum probiotic-treated (PR) groups. HTH and PR groups were regularly housed at 30 ± 0.5 °C with humidity of 85–90% for eight consecutive weeks. A broad-spectrum probiotic was administrated to PR-group mice from day 50 to 56. Clinical signs were observed and gut microbiota were analyzed via 16 S rRNA-based functional metagenomics. Intestinal pathology and the expression of defensins and pro-inflammatory cytokines were also assessed. Mice in the HTH and PR groups gradually developed sticky or loose feces. The HTH group developed a distinct microbiota profile associated with augmented metabolism and human-like pathophysiologies upon suppression of environmental sensing. Pathological assays indicated minimal enteritis, increased bacterial translocation, and elevated intestinal pro-inflammatory cytokine levels. Thus, ambient HTH directly contributes to gut dysbiosis and minimal enteritis, whereas probiotics partially normalized the microbiota and ameliorated gut inflammation. This study provides novel insights into the pathogenesis of environment-associated diseases and offers a potential therapeutic approach.
Genome wide association study of 5 agronomic traits in olive (Olea europaea L.)
Authors: Kaya Hilal Betul , Akdemir Deniz , Lozano Roberto , Cetin Oznur , Sozer Kaya Hulya , Sahin Mustafa , Smith Jenny L. , Tanyolac Bahattin , Jannink Jean-Luc 
Published: December 2019

AbstractOlive (Olea europaea L.) is one of the most economically and historically important fruit crops worldwide. Genetic progress for valuable agronomic traits has been slow in olive despite its importance and benefits. Advances in next generation sequencing technologies provide inexpensive and highly reproducible genotyping approaches such as Genotyping by Sequencing, enabling genome wide association study (GWAS). Here we present the first comprehensive GWAS study on olive using GBS. A total of 183 accessions (FULL panel) were genotyped using GBS, 94 from the Turkish Olive GenBank Resource (TOGR panel) and 89 from the USDA-ARS National Clonal Germplasm Repository (NCGR panel) in the USA. After filtering low quality and redundant markers, GWAS was conducted using 24,977 SNPs in FULL, TOGR and NCGR panels. In total, 52 significant associations were detected for leaf length, fruit weight, stone weight and fruit flesh to pit ratio using the MLM_K. Significant GWAS hits were mapped to their positions and 19 candidate genes were identified within a 10-kb distance of the most significant SNP. Our findings provide a framework for the development of markers and identification of candidate genes that could be used in olive breeding programs.
Computational holographic Maxwellian near-eye display with an expanded eyebox
Authors: Chang Chenliang , Cui Wei , Park Jongchan , Gao Liang 
Published: December 2019

AbstractThe Maxwellian near-eye displays have attracted growing interest in various applications. By using a confined pupil, a Maxwellian display presents an all-in-focus image to the viewer where the image formed on the retina is independent of the optical power of the eye. Despite being a promising technique, current Maxwellian near-eye displays suffer from various limitations such as a small eyebox, a bulky setup and a high cost. To overcome these drawbacks, we present a holographic Maxwellian near-eye display based on computational imaging. By encoding a complex wavefront into amplitude-only signals, we can readily display the computed histogram on a widely-accessible device such as a liquid-crystal or digital light processing display, creating an all-in-focus virtual image augmented on the real-world objects. Additionally, to expand the eyebox, we multiplex the hologram with multiple off-axis plane waves, duplicating the pupils into an array. The resultant method features a compact form factor because it requires only one active electronic component, lending credence to its wearable applications.
Improved survival after early detection of asymptomatic distant metastasis in patients with thyroid cancer
Authors: Kim Hosu , Park So Young , Jung Jaehoon , Kim Jung-Han , Hahn Soo Yeon , Shin Jung Hee , Oh Young Lyun , Chung Man Ki , Kim Hye In , Kim Sun Wook , Chung Jae Hoon , Kim Tae Hyuk 
Published: December 2019

AbstractThe incidence of thyroid cancer (TC) has been increasing in many countries and concerns about overdiagnosis are also widely shared. However, early detection may be helpful in some high-risk TC patients, such as those with initial distant metastasis. We conducted this study to evaluate the usefulness of early detection in TC patients with initial distant metastasis. We retrospectively reviewed the clinical data of 13,249 TC patients, and found 127 patients with initial distant metastasis. Enrolled patients were divided into two groups according to the diagnostic periods; before and after 2004, when the early detection of TC by ultrasonography began in earnest in Korea. Patients were also divided into two groups according to the presence of symptoms. Prior to 2004, 33 patients (1.7% of TC patients) were diagnosed with TC with initial distant metastasis and 16 (48.5%) of them died. After 2004, 94 patients (0.8% of TC patients) were diagnosed with TC with initial distant metastasis and 29 (30.9%) of them died. Prior to 2004, the disease-specific death rates were similar between the asymptomatic and symptomatic groups (46.2% vs. 50.0%, P = 0.566). Conversely, after 2004, the asymptomatic group showed a significantly lower disease-specific death rate as compared with that of the symptomatic groups (17.2% vs. 60.0%; P < 0.001). Early detection had a significant positive impact on survival outcomes only after 2004, especially in asymptomatic TC patients with initial distant metastasis.
Kinematic and metallicity properties of the Aquarius dwarf galaxy from FORS2 MXU spectroscopy
Authors: Hermosa Muñoz L. , Taibi S. , Battaglia G. , Iorio G. , Rejkuba M. , Leaman R. , Cole A. A. , Irwin M. , Jablonka P. , Kacharov N. , McConnachie A. , Starkenburg E. , Tolstoy E. 
Published: December 2019

Context. Dwarf galaxies found in isolation in the Local Group (LG) are unlikely to have interacted with the large LG spirals, and therefore environmental effects such as tidal and ram-pressure stripping should not be the main drivers of their evolution.
Aims. We provide insight into the internal mechanisms shaping LG dwarf galaxies by increasing our knowledge of the internal properties of isolated systems. Here we focus on the evolved stellar component of the Aquarius dwarf galaxy, whose kinematic and metallicity properties have only recently started to be explored.
Methods. Spectroscopic data in the region of the near-infrared Ca II triplet lines has been obtained with FORS2 at the Very Large Telescope for 53 red giant branch (RGB) stars. These data are used to derive line-of-sight (l.o.s.) velocities and [Fe/H] of the individual RGB stars.
Results. We derive a systemic velocity of −142.2+1.8−1.8 km s−1, in agreement with previous determinations from both the HI gas and stars. The internal kinematics of Aquarius appears to be best modelled by a combination of random motions (l.o.s. velocity dispersion of 10.3+1.6−1.3 km s−1) and linear rotation (with a gradient −5.0+1.6−1.9 km s−1 arcmin−1) along a PA = 139+17−27 deg, broadly consistent with the optical projected major axis. This rotation signal is significantly misaligned or even counter-rotating to that derived from the HI gas. We also find the tentative presence of a mild negative metallicity gradient and indications that the metal-rich stars have a colder velocity dispersion than the metal-poor ones.
Conclusions. This work represents a significant improvement with respect to previous measurements of the RGB stars of Aquarius as it doubles the number of member stars already studied in the literature. We speculate that the misaligned rotation between the HI gas and evolved stellar component might have been the result of recent accretion of HI gas, or re-accretion after gas-loss due to internal stellar feedback.
Hydrodynamic simulations unravel the progenitor-supernova-remnant connection in SN 1987A
Authors: Orlando S. , Ono M. , Nagataki S. , Miceli M. , Umeda H. , Ferrand G. , Bocchino F. , Petruk O. , Peres G. , Takahashi K. , Yoshida T. 
Published: December 2019

Context.Massive stars end their lives in catastrophic supernova (SN) explosions. Key information on the explosion processes and on the progenitor stars can be extracted from observations of supernova remnants (SNRs), which are the outcome of SNe. Deciphering these observations, however, is challenging because of the complex morphology of SNRs.Aims.We aim to link the dynamical and radiative properties of the remnant of SN 1987A to the geometrical and physical characteristics of the parent aspherical SN explosion and to the internal structure of its progenitor star.Methods.We performed comprehensive three-dimensional hydrodynamic simulations which describe the long-term evolution of SN 1987A from the onset of the SN to the full-fledged remnant at the age of 50 years, accounting for the pre-SN structure of the progenitor star. The simulations include all physical processes relevant for the complex phases of SN evolution and for the interaction of the SNR with the highly inhomogeneous ambient environment around SN 1987A. Furthermore, the simulations follow the life cycle of elements from the synthesis in the progenitor star through the nuclear reaction network of the SN to the enrichment of the circumstellar medium as a result of the mixing of chemically homogeneous layers of ejecta. From the simulations, we synthesize observables that are to be compared with observations.Results.By comparing the model results with observations, we constrained the initial SN anisotropy causing Doppler shifts, observed in the emission lines of heavy elements from ejecta, and leading to the remnant evolution observed in the X-ray band in the last thirty years. In particular, we found that the high mixing of ejecta unveiled by high redshifts and broadenings of [Fe II] and44Ti lines require a highly asymmetric SN explosion channeling a significant fraction of energy along an axis that is almost lying in the plane of the central equatorial ring around SN 1987A, roughly along the line-of-sight, but with an offset of 40°, with the lobe propagating away from the observer slightly more energetic than the other. Furthermore, we found unambiguously that the observed distribution of ejecta and the dynamical and radiative properties of the SNR can be best reproduced if the structure of the progenitor star was that of a blue supergiant which had resulted from the merging of two massive stars.
Wind of change: retrieving exoplanet atmospheric winds from high-resolution spectroscopy
Authors: Seidel J. V. , Ehrenreich D. , Pino L. , Bourrier V. , Lavie B. , Allart R. , Wyttenbach A. , Lovis C. 
Published: December 2019

Context. The atmosphere of exoplanets has been studied extensively in recent years, making use of numerical models to retrieve chemical composition, dynamical circulation, or temperature from the data. One of the best observational probes in transmission is the sodium doublet thanks to its extensive cross-section. However, modelling the shape of planetary sodium lines has proven to be challenging. Models with different assumptions regarding the atmosphere have been employed to fit the lines in the literature, yet statistically-sound, direct comparisons of different models are needed to paint a clear picture.
Aims. We aim to compare different wind and temperature patterns, as well as to provide a tool to distinguish them based on their best fit for the sodium transmission spectrum of the hot Jupiter HD 189733b. We parametrise different possible wind patterns that have already been tested the in literature and introduce the new option of an upwards-driven vertical wind.
Methods. We construct a forward model where the wind speed, wind geometry, and temperature are injected into the calculation of the transmission spectrum. We embed this forward model in a nested sampling retrieval code to rank the models via their Bayesian evidence.
Results. We retrieve a best-fit to the HD 189733b data for vertical upward winds |vver(mean)| = 40 ± 4 km s−1 at altitudes above 10−6 bar. With the current data from HARPS, we cannot distinguish wind patterns for higher-pressure atmospheric layers.
Conclusions. We show that vertical upwards winds in the upper atmosphere provide a possible explanation for the broad sodium signature in hot Jupiters. We highlight other influences on the width of the doublet and we explore strong magnetic fields acting on the lower atmosphere as one possible origin of the retrieved wind speed.
Apparent superluminal core expansion and limb brightening in the candidate neutrino blazar TXS 0506+056
Authors: Ros E. , Kadler M. , Perucho M. , Boccardi B. , Cao H.-M. , Giroletti M. , Krauß F. , Ojha R. 
Published: December 2019

Context.IceCube has reported a very-high-energy neutrino (IceCube-170922A) in a region containing the blazarTXS 0506+056. Correlated gamma-ray activity has led to the first high-probability association of a high-energy neutrino with an extragalactic source. This blazar has been found to be in a radio outburst during the neutrino event.Aims.Our goal is to probe the sub-milliarcsecond properties of the radio jet right after the neutrino detection and during the further evolution of the radio outburst.Methods.We performed target of opportunity observations at 43 GHz frequency using very long baseline interferometry imaging, corresponding to 7 mm in wavelength, with the Very Long Baseline Array two and eight months after the neutrino event.Results.We produced two images of the radio jet of TXS 0506+056 at 43 GHz with angular resolutions of (0.2 × 1.1) mas and (0.2 × 0.5) mas, respectively. The source shows a compact, high brightness temperature core, albeit not approaching the equipartition limit and a bright and originally very collimated inner jet. Beyond approximately 0.5 mas from the millimeter-VLBI core, the jet loses this tight collimation and expands rapidly. During the months after the neutrino event associated with this source, the overall flux density is rising. This flux density increase happens solely within the core. Notably, the core expands in size with apparent superluminal velocity during these six months so that the brightness temperature drops by a factor of three despite the strong flux density increase.Conclusions.The radio jet of TXS 0506+056 shows strong signs of deceleration and/or a spine-sheath structure within the inner 1 mas, corresponding to about 70–140 pc in deprojected distance, from the millimeter-VLBI core. This structure is consistent with theoretical models that attribute the neutrino and gamma-ray production in TXS 0506+056 to interactions of electrons and protons in the highly relativistic jet spine with external photons originating from a slower moving jet region. Proton loading due to jet-star interactions in the inner host galaxy is suggested as the possible cause of deceleration.
Metal Ion Release after Hip and Knee Arthroplasty – Causes, Biological Effects and Diagnostics
Authors: Lützner Jörg , Günther Klaus-Peter , Postler Anne , Morlock Michael 
Published: December 2019

AbstractAll metal implants in human bodies corrode which results in metal ions release. This is not necessarily a problem and represents for most patients no hazard. However, if a critical metal ion concentration is exceeded, local or rarely systemic problems can occur. This article summarizes the mechanisms of metal ion release and its clinical consequences. Several situations can result in increased metal ion release: metal-on-metal hip arthroplasties with increased wear, increased micromotion at taper interfaces, direct metal-metal contact (polyethylene wear, impingement), erroneously used metal heads after ceramic head fracture. Possible problems are in most cases located close to the concerned joint. Furthermore, there are reports about toxic damage to several organs. Most of these reports refer to erroneously used metal heads in revisions after a broken ceramic head. There is currently no evidence of carcinogenic or teratogenic effects of implants but data is not
sufficient to exclude possible effects. Cobalt and chromium blood levels (favorably in whole blood) should be measured in patients with suspected elevated metal ions. According to current knowledge levels below 2 µg/l seem to be uncritical, levels between 2 and 7 µg/l are considered borderline with unknown biological consequences and levels above 7 µg/l indicate a local problem which should be further diagnosed. Metal ion levels always need to be interpreted together with clinical symptoms and imaging results.
Orthopädische Schuhtechnik
Authors: Greitemann Bernhard , Schievink Frank 
Published: December 2019

AbstractOrthopedic footwear care is a means that orthopedists and traumatologists in the German-speaking regions have at their disposal due to the long-standing tradition in the crafts sector. The prescription for orthopedic care is based on the patient’s functional deficit: e. g. foot deformities, degenerative joint diseases of the foot, knee and hip, trauma, metabolic, neurological and rheumatic diseases, tumors, inflammatory transformation, skin and nail diseases, pressure calluses, static alteration and leg length differences. Orthopedic footwear supplies are an essential component of conservative and postoperative orthopedic and traumatic therapy. Orthopedic shoe modifications include orthopedic insoles, alterations on ready-to-wear shoes, foot orthoses or prosthetic foot orthoses, custom orthopedic footwear, standard orthopedic footwear (training shoes, semi-orthopedic shoes, protective footwear) and orthopedic specialty footwear.
Coexistent adenoma and serrated polyps on index colonoscopy and the risk of metachronous advanced colorectal neoplasia
Authors: Park Soo-Kyung , Kim Hak-Soo , Yang Hyo-Joon , Jung Yoon Suk , Park Jung Ho , Sohn Chong Il , Park Sang Hyun , Sohn Jin Hee , Lee Mi Yeon , Park Dong Il 
Published: December 2019

Abstract
Background and aims The family of serrated polyps (SP) includes hyperplastic polyps (HP), sessile serrated adenomas/polyps, and traditional serrated adenoma. We investigated whether SP synchronous with adenoma at index colonoscopy is associated with metachronous advanced colorectal neoplasia (CRN).
Methods Patients with ≥ 1 adenoma on index colonoscopy and who had undergone a follow-up colonoscopy were included. The patients were divided into four groups according to the presence of SP and advanced adenoma (AA) on index colonoscopy (non-AA, non-AA + SP, AA, AA + SP). The cumulative incidence of metachronous advanced CRN at surveillance colonoscopy was compared between groups.
Results Among a total of 2209 patients, the numbers of patients in the non-AA, non-AA + SP, AA, and AA + SP groups were 922, 441, 625, and 221, respectively. The cumulative incidence of metachronous advanced CRN was higher in patients in the AA + SP group than that in the AA group (P<0.001), and there was no significant difference between the non-AA + SP group and the non-AA group (P = 0.06). The cumulative incidence of metachronous advanced CRN at 3 years was 17.9 % [95 % confidence interval (CI) 8.0–27.6], 10.7 % [95 %CI 7.7–3.6], 3.5 % [95 %CI 1.3–5.6], and 3.4 % [95 %CI 2.0–4.7] in the AA + SP, AA, non-AA + SP, and non-AA group, respectively. In a multivariate analysis, overall SP [hazard ratio (HR) 2.24; 95 %CI 1.38–3.64, P = 0.001], proximal SP (HR 2.31; 95 %CI 1.32–4.08), and HP (HR 2.19; 95 %CI 1.35–3.57) were risk factors for metachronous advanced CRN in patients with AA on index colonoscopy.
Conclusions Coexistent AA and SP on index colonoscopy significantly increased the risk of metachronous advanced CRN compared with AA alone. Further large prospective studies are needed to confirm whether more intensive follow-up improves outcomes in these high risk patients.
Needle-knife fistulotomy vs. standard biliary sphincterotomy for choledocholithiasis: common bile duct stone recurrence and complication rate
Authors: Archibugi Livia , Mariani Alberto , Capurso Gabriele , Traini Mariaemilia , Petrone Maria Chiara , Rossi Gemma , Testoni Sabrina Gloria Giulia , Testoni Pier Alberto , Arcidiacono Paolo Giorgio 
Published: December 2019

Abstract
Background and study aims With common bile duct (CBD) stones, access to the CBD can be achieved through the papilla orifice followed by standard biliary sphincterotomy (SBS), or through precut fistulotomy (PF) in case of difficult cannulation. The two methods alter papilla anatomy differently, potentially leading to a different rate of stone recurrence. No data have been published on stone recurrence after PF in patients with CBD stones. The aim of this study was to evaluate CBD stone recurrence, reintervention rate after PF versus SBS, and complications.
Patients and methods This was a retrospective single-center cohort study including patients undergoing for the first time endoscopic retrograde cholangiopancreatography (ERCP) for CBD stones with PF in case of failed repeated cannulation attempts, matched for sex/age to patients with SBS randomly extracted from our database. T-test and Fisher’s tests were used for continuous and categorical variable comparison. Recurrence probability was calculated with Kaplan–Meier curve. Factors associated with ERCP repetition were evaluated with logistic regression through a Cox’s proportional hazards model.
Results Eighty-five patients with PF were included, with 85 matched controls (mean age 68.7 years, 45.9 % males). Overall, patients with PF had the same reintervention rate as those with SBS (14.1 % vs. 12.9 %) with a hazard ratio (HR) of 1.11 (95 % CI 0.49 – 2.50; P = 0.81), but mean time to reintervention was significantly lower (74.9 ± 74.6 vs. 765.6 ± 961.3 days; P < 0.0001), with 100 % of stones recurring within the first year in the PF group vs. 54.5 % in the SBS group (P = 0.01). The only factor associated with ERCP repetition risk was incomplete CBD clearing. Complications, including pancreatitis, did not differ significantly.
Conclusions The reintervention rate was significantly higher in the short term after PF. Therefore, closer follow-up in the first 6 to 12 months after ERCP might be appropriate for patients underoing PF.