bluuebunny/crossref_metadata_2025_split huggingface dataset:
The inhibiting effects of resistance to change of disability determination system: a status quo bias perspective
Authors: Chi Wen-Chou , Lin Po-Jin , Chang I-Chiu , Chen Sing-Liang 
Published: April 2020

Abstract
Background
Information systems implementation projects have been historically plagued by failures for which user resistance has consistently been identified as a salient reason. Most prior studies investigated either the causes or the consequences of Resistance to Change (RTC) of medical related Information Systems. In this study, we simultaneously explore the causes and impacts of RTC of Disability Determination System (DDS).

Methods
This study adopts the Status Quo Bias perspective and combines the information systems usage model and Technology Acceptance Model (TAM) as theoretical foundation to investigates the causes and impacts of users’ RTC on their intention to use the DDS. Data were obtained through internet questionnaire survey. Totally, 326 respondents from 22 local governments and 142 hospitals were collected, of which 252 were valid samples and were analyzed using structure model analysis.

Results
The research model is proved with eight out of 11 hypotheses being supported. The antecedents of RTC can explain 21.4% of the RTC variation, and the RTC impacts can explain 57.5% of the variation of intention to use DDS.

Conclusions
Combining the Status Quo Bias perspective and key component of TAM provides an adequate explanation of adopting intention of changing systems and extend the existing knowledge of information systems adoption. The results provide as a reference for managing users’ RTC and enhance the effects and efficiency of new systems adoption.
Home care quality indicators based on the Resident Assessment Instrument-Home Care (RAI-HC): a systematic review
Authors: Wagner Aylin , Schaffert René , Möckli Nathalie , Zúñiga Franziska , Dratva Julia 
Published: April 2020

Abstract
Background
One way of measuring the quality of home care are quality indicators (QIs) derived from data collected with the Resident Assessment Instrument-Home Care (RAI-HC). In order to produce meaningful results for quality improvement and quality comparisons across home care organizations (HCOs) and over time, RAI-HC QIs must be valid and reliable. The aim of this systematic review was to identify currently existing RAI-HC QIs and to summarize the scientific knowledge on the validity and reliability of these QIs.

Methods
A systematic review was performed using the electronic databases PubMed, CINAHL, Embase, PsycINFO and Cochrane Library. Studies describing the development process or the psychometric characteristics of RAI-HC QIs were eligible. The data extraction involved a general description of the included studies as well as the identified RAI-HC QIs and information on validity and reliability. The methodological quality of the identified RAI-HC QI sets was assessed using the Appraisal of Indicators through Research and Evaluation (AIRE) instrument.

Results
Four studies out of 659 initial hits met the inclusion criteria. The included studies described the development and validation process of three RAI-HC QI sets comprising 48 unique RAI-HC QIs, which predominantly refer to outcome of care. Overall, the validity and reliability of the identified RAI-HC QIs were not sufficiently tested. The methodological quality of the three identified RAI-HC QI sets varied across the four AIRE instrument domains. None of the QI sets reached high methodological quality, defined as scores of 50% and higher in all four AIRE instrument domains.

Conclusions
This is the first review that systematically summarized and appraised the available scientific evidence on the validity and reliability of RAI-HC QIs. It identified insufficient reporting of RAI-HC QIs validation processes and reliability as well as missing state-of-the-art methodologies. The review provides guidance as to what additional validity and reliability testing are needed to strengthen the scientific soundness of RAI-HC QIs. Considering that RAI-HC QIs are already implemented and used to measure and compare quality of home care, further investigations on RAI-HC QIs reliability and validity is recommended.
Macromolecular crowding links ribosomal protein gene dosage to growth rate in Vibrio cholerae
Authors: Soler-Bistué Alfonso , Aguilar-Pierlé Sebastián , Garcia-Garcerá Marc , Val Marie-Eve , Sismeiro Odile , Varet Hugo , Sieira Rodrigo , Krin Evelyne , Skovgaard Ole , Comerci Diego J. , Rocha Eduardo P. C. , Mazel Didier 
Published: April 2020

AbstractBackgroundIn fast-growing bacteria, the genomic location of ribosomal protein (RP) genes is biased towards the replication origin (oriC). This trait allows optimizing their expression during exponential phase sinceoriCneighboring regions are in higher dose due to multifork replication. Relocation ofs10-spc-αlocus (S10), which codes for most of the RP, to ectopic genomic positions shows that its relative distance to theoriCcorrelates to a reduction on its dosage, its expression, and bacterial growth rate. However, a mechanism linking S10 dosage to cell physiology has still not been determined.ResultsWe hypothesized that S10 dosage perturbations impact protein synthesis capacity. Strikingly, we observed that inVibrio cholerae, protein production capacity was independent of S10 position. Deep sequencing revealed that S10 relocation altered chromosomal replication dynamics and genome-wide transcription. Such changes increased as a function oforiC-S10 distance. Since RP constitutes a large proportion of cell mass, lower S10 dosage could lead to changes in macromolecular crowding, impacting cell physiology. Accordingly, cytoplasm fluidity was higher in mutants where S10 is most distant fromoriC. In hyperosmotic conditions, when crowding differences are minimized, the growth rate and replication dynamics were highly alleviated in these strains.ConclusionsThe genomic location of RP genes ensures its optimal dosage. However, besides of its essential function in translation, their genomic position sustains an optimal macromolecular crowding essential for maximizing growth. Hence, this could be another mechanism coordinating DNA replication to bacterial growth.
Recent insights into eukaryotic translation initiation factors 5A1 and 5A2 and their roles in human health and disease
Authors: Wu Gao-Qi , Xu Yan-Ming , Lau Andy T. Y. 
Published: April 2020

AbstractThe eukaryotic translation initiation factor 5A1 (eIF5A1) and its homolog eIF5A2 are the only two human proteins containing the unique post-translational modification–hypusination, which is essential for the function of these two proteins. eIF5A1 was initially identified as a translation initiation factor by promoting the first peptide bond formation of protein during translation; however, recent results suggest that eIF5A1 also functions as a translation elongation factor. It has been shown that eIF5A1 is implicated in certain human diseases, including diabetes, several human cancer types, viral infections and diseases of neural system. Meanwhile, eIF5A2 is overexpressed in many cancers, and plays an important role in the development and progression of cancers. As multiple roles of these two factors were observed among these studies, therefore, it remains unclear whether they act as oncogene or tumor suppressor. In this review, the recent literature of eIF5As and their roles in human diseases, especially in human cancers, will be discussed.
The use of a task through virtual reality in cerebral palsy using two different interaction devices (concrete and abstract) – a cross-sectional randomized study
Authors: Leal Andréa Fernanda , da Silva Talita Dias , Lopes Priscila Bianchi , Bahadori Shayan , de Araújo Luciano Vieira , da Costa Murillo Vinicius Brandão , de Moraes Íbis Ariana Peña , Marques Ricardo Henrique , Crocetta Tania Brusque , de Abreu Luiz Carlos , Monteiro Carlos Bandeira de Mello 
Published: April 2020

Abstract
Background
Cerebral Palsy (CP) is characterised by variable difficulties in muscular action, resulting in inability of the individual to perform functional movement. An option to provide functionality to the individual with CP is the use of computer innovation. The aim of this paper was to verify if there was any performance improvement in a task performed in a virtual environment and if there was transfer to the task performed in the real environment and vice versa in this population.

Methods
A computer program was developed comprising a motor task, but with two possibilities of user interaction: a) concrete interface (with physical contact): in which the individual touches the computer screen to finish the task and b) abstract interface (no physical contact): in which the individual performs a hand movement in front of the Kinect device. Participants were split into two groups. The experimental group consisted of 28 individuals with CP within the ages of 6 and 15 years old. The control group included 28 typically developing individuals mirroring the age and sex of the experimental group.

Results
Individuals from both groups were able to improve task performance and retain acquired information. The CP group presented worse performance than the control group in all phases of the study. Further findings showed that the CP group presented better performance in the abstract interface than in the concrete interface, whereas, in the control group, the opposite occurred: their best performance was in the concrete.

Conclusions
Motor tasks performed by individuals with CP through an interface with a more virtual environment feature (abstract interface: Kinect) provided better performance when compared to an interface with a more real characteristic (concrete interface: Touchscreen).

Trial registration
ClinicalTrials.gov Identifier - NCT03352440; Date of registration - November 17, 2017.
Psychological, social, and motivational factors in persons who use drugs
Authors: Shahrabadi Sana , Jalali Amir , Jalali Rostam , Gholami Ali 
Published: April 2020

Abstract
Background
Persons who use drug need family and society’s support in the process of treatment and rehabilitation. Therefore, it is imperative to determine the psychological, social, and motivational factors that can help them in the treatment process. The present study was an attempt to determine the relationship between psychological, social, and motivational factors and the demographics of persons who use drugs (PWUD).

Methods
An analytical cross-sectional study was carried out. TCU psychological functioning and motivation scales for the PWUD was first translated into Farsi and validated after securing permission from the copyright holder of the tool. Participants were 250 PWUDs under methadone therapy who were selected through convenient sampling. Before analyzing the collected data, validity and reliability of the tool were confirmed using confirmatory and exploratory factor analyses. Given the scale of demographical data, descriptive and analytic statistics were used to analyze the relationship between demographical variables and psychological, social, and motivational factors.

Results
The results of exploratory and confirmatory factor analyses showed that out of 83 statements in the original questionnaire, 55 statements categorized into 11 aspects were usable for Iranian population. The results showed that gender, income, and marital status affect psychological functioning of the PWUD (P < 0.05). However, education level, place of residence, and type of drug and consumption did not have a significant relationship with social functioning of the participants (p > 0.05). There was a significant relationship between age, number of children, and history of using drug and psychological functioning of the participants (P < 0.01). The results showed that the demographics did not have a notable effect on the participants’ motivation for treatment; only marital status had a significant relationship with the participants’ treatment readiness (P < 0.05).

Conclusion
As the results showed, the demographical variables could affect physical, psychological, and social functioning in the participants.
Risk factors and treatments for disseminated intravascular coagulation in neonates
Authors: Go Hayato , Ohto Hitoshi , Nollet Kenneth E. , Kashiwabara Nozomi , Ogasawara Kei , Chishiki Mina , Hiruta Shun , Sakuma Ichiri , Kawasaki Yukihiko , Hosoya Mitsuaki 
Published: April 2020

Abstract
Background
Although disseminated intravascular coagulation (DIC) is a critical disease, there is few gold standard interventions in neonatal medicine. The aim of this study is to reveal factors affecting neonatal DIC at birth and to assess the effectiveness of rTM and FFP for DIC in neonates at birth.

Methods
We retrospectively evaluated DIC score on the first day of life in neonates with underlying conditions associated with DIC. DIC in neonates was diagnosed according to Japan Society of Obstetrical, Gynecological & Neonatal Hematology 2016 neonatal DIC criteria.

Results
Comparing neonates with DIC scores of ≥3 (n = 103) to those < 3 (n = 263), SGA, birth asphyxia, low Apgar score, hemangioma, hydrops, PIH, and PA were statistically increased. Among 55 neonates underwent DIC treatment, 53 had birth asphyxia and 12 had intraventricular hemorrhage. Forty-one neonates received FFP or a combination of FFP and antithrombin (FFP group), while 14 neonates received rTM or a combination of rTM, FFP, and antithrombin (rTM group). DIC score before treatment in the rTM group was significantly higher than in the FFP group (4.7 vs 3.6, P < 0.05). After treatment, DIC scores in both groups were significantly reduced on Day 1 and Day 2 (P < 0.05).

Conclusions
Among various factors associated with DIC in neonates at birth, birth asphyxia is particularly significant. Furthermore, rTM in combination with FFP therapy was effective for neonatal DIC at birth.
Expectations and psychological issues before genetic counseling: analysis of distress determinant factors
Authors: Ballatore Zelmira , Bracci Raffaella , Maccaroni Elena , Svarca Lucia , Bianchi Francesca , Belvederesi Laura , Brugiati Cristiana , Pagliaretta Silvia , Murrone Alberto , Bini Federica , Pistelli Mirco , Ricci Giulia , Berardi Rossana 
Published: April 2020

Abstract
Background
Hereditary non-polyposis colorectal cancer (HNPCC) and Hereditary Breast and Ovarian Cancer Syndrome (HBOC) are the most common hereditary cancer syndromes in which a genetic test is available. Potential risks associated with testing include psychological harm, emotional distress and insurance problems.

Methods
The aim of the present study is to investigate determinants of distress in a sample of Italian subjects undergoing genetic counseling. Demographic information and psychological distress were assessed by using a self-reported questionnaire and the “Hospital Anxiety and Depression Scale” (HAD), before attending the first counseling session.

Results
Of the all subjects referred for the first time to our Center (January 2012–June 2013), a total of 227 were eligible (female/male = 174/53) for the survey, 134 (59%) were oncologic patients and of these, 116 received genetic test (36 for HNPCC and 80 for HBOC). The remaining 93 (41%) were healthy subjects referred for suspected familiar history and of this group, 65 subjects performed predictive test in a family with a known pathogenic mutation (53 for HBOC and 12 for HNPCC). Affected subjects had a significantly higher level of anxiety (p = 0.02) and HAD global score (p = 0.01) than healthy ones. There was no difference in HAD score between individuals testing for different syndromes (p = 0.3). In the affected subgroup, there was a significant linear correlation between the HAD anxiety score and how much subjects perceived their disease as hereditary (p = 0.01). Female and younger subjects had higher levels of anxiety (p = 0.05). Also healthy single subjects show more general distress (p = 0.02) than those with a partner.

Conclusions
Greater level of distress identified on females, single and younger subjects.
A study on Copson operator and its associated sequence space
Authors: Roopaei Hadi 
Published: April 2020

AbstractIn this research, we investigate two types of Copson matrices, the generalized Copson matrix and the Copson matrix of order n, and their associated sequence spaces generated by these matrices. We also investigate the topological properties, inclusions, and dual spaces of these new Banach spaces as well as compute the norm of Copson operators on the well-known matrix domains such as Hilbert and difference sequence spaces. Moreover, in a reverse manner, we investigate the norm of well-known operators on the Copson matrix domains generated with Copson matrices. Through this study we introduce several new inequalities, inclusions, and factorizations for well-known operators.
Chirped optical soliton perturbation of Fokas–Lenells equation with full nonlinearity
Authors: Al-Ghafri K. S. , Krishnan E. V. , Biswas Anjan 
Published: April 2020

AbstractThe present paper focuses on the chirped soliton solutions of the Fokas–Lenells equation in the presence of perturbation terms. A complex envelope traveling-wave solution is used to reduce the governing equation to an ordinary differential equation (ODE). An auxiliary equation in the form of a first-order nonlinear ODE with six-degree terms is implemented as a solution method. Various types of chirped soliton solutions including bright, dark, kink and singular solitons are extracted. The associated chirp is also determined for each of these optical pulses. Restrictions for the validity of chirped soliton solutions are presented.
Overexpressed immunoglobulin-like transcript (ILT) 4 in lung adenocarcinoma is correlated with immunosuppressive T cell subset infiltration and poor patient outcomes
Authors: Li Qing , Li Juan , Wang Shuyun , Wang Jingnan , Chen Xiaozheng , Zhou Dongmei , Fang Yuying , Gao Aiqin , Sun Yuping 
Published: April 2020

Abstract
Background
The poor response to current PD-1/PD-L1 inhibitors in lung cancer patients requires development of novel immunotargets. Immunoglobulin-like transcript (ILT)4 is an immunosuppressive molecule mainly expressed in myeloid innate cells. Recent studies showed that ILT4 was highly expressed in multiple malignant cells and regulated tumor biologies including proliferation, invasion and metastasis. However, the immunomodulatory role of tumor cell-derived ILT4 is unclear. Here we aimed to analyze the correlation of tumor cell ILT4 expression with T cell infiltration and subset distribution, illustrate ILT4-regulated immunosuppressive microenvironment, and raise tumor cell-derived ILT4 as a novel immunotherapeutic target and prognostic biomarker for lung adenocarcinoma (LUAD) patients.

Methods
We collected the tissue samples and corresponding clinicopathological data from 216 primary LUAD patients. Using immunohistochemical staining and public database analyses we investigated the relationship between ILT4 expression and different T cell subset density as well as patient outcomes.

Results
Enriched ILT4 expression in tumor cells of LUAD tissues indicated reduced T cell infiltration in the tumor microenvironment (TME), advanced diseases and poor patient overall survival (OS). Further T cell subset analyses revealed that ILT4 expression was correlated with decreased CD8+T cell and increased Treg frequency in both cancer nest and stroma, but not with altered CD4+T cell frequency. High ILT4 level combined with low CD8+T cell/high Treg density predicted markedly poorer clinical outcomes compared with any of these biomarkers alone.

Conclusions
Tumor cell-derived ILT4 is correlated with immunosuppressive T cell subset infiltration and poor clinical outcomes, and might be a potential immunotherapeutic target and prognostic biomarker for LUAD patients. Combined ILT4 expression and CD8+ T cell/Treg frequency in tumor infiltrating lymphocytes (TILs) are stronger predictors for patient outcomes.
Innovative methods for the removal, and occasionally care, of pressure sensitive adhesive tapes from contemporary drawings
Authors: Mirabile Antonio , Chelazzi David , Ferrari Pamela , Montis Costanza , Berti Debora , Bonelli Nicole , Giorgi Rodorico , Baglioni Piero 
Published: April 2020

Abstract
Aged pressure sensitive tapes (PSTs) can compromise the integrity and readability of drawings and paper artworks. Typically, PSTs on contemporary artifacts are difficult to remove owing to degradation processes and to the intrinsic sensitiveness of paper, inks and dyes to the solvents and tools used in the traditional conservation practice. Alternatively, we provide here a critical overview and expansion on the use of two recently developed methodologies for the removal of PSTs, based on the confinement of cleaning fluids in retentive gels. Various combinations of PSTs backings and adhesives were addressed on paper mock-ups containing different types of artistic media (inks, dyes), monitoring the ability of a hydrogel and an organogel to gradually exchange, respectively, an oil-in-water microemulsion or diethyl carbonate through the PSTs backings, swelling the adhesive layers and enabling safe PST removal. It was shown that the two methodologies are complementary as they target the removal of tapes with different components. In all cases, selective tape removal was carried out without uncontrolled bleeding of inks or transport of dissolved matter through the paper matrix, thanks to the retentiveness of the gels. The two cleaning systems were then assessed on four completely different artworks on paper, where they proved to be versatile tools to remove aged PSTs, or re-adhere detackified tapes that were part of the original artwork. Overall, the two methodologies complement each other and allowed overcoming the limitations of traditional cleaning approaches.
Fasting insulin level and Homatest IR as predictors of acute kidney injury in critically ill patients
Authors: Fayed Ahmed , Soliman Ahmed , Badr Mohamed , Abdelmoniem Mohamed , Drwesh Hesham , Fakher Mohamed , Soliman Mahmoud Salem 
Published: April 2020

Abstract
Background
Kidney dysfunction is a major cause of morbidity and mortality whose prevalence, mainly because of population ageing, is rising worldwide. Also the epidemics of abnormalities clustering with insulin resistance might have played a role in increasing the prevalence of kidney dysfunction. Insulin resistance has been associated with increased risk of cardiovascular events and mortality in multiple large community-based cohort studies.

Objective
The aim of the study is to prove that insulin resistance not only may have a role in the development of chronic kidney disease but also may have a role in acute kidney injury.

Methods
This was a case-control study. The cases of the study were taken from the medical intensive care unit (ICU) of the Faculty of Medicine Cairo University, 100 control patients stratified by age and gender and 219 critically ill ICU patients with AKI.

Results
In the current study, we find that there is statistically significant higher fasting insulin levels and higher levels Homa IR in patients with AKI than patients without AKI. These results signify that patients with AKI had insulin resistance. In our study, the Homa IR showed non-significant correlation with APACHE and SOFA score. While fasting insulin level shows significant correlation only with SOFA score after 96 h.

Conclusion
Our present observations indicate that patients with acute kidney injury have statistically significant higher insulin resistance.