bluuebunny/crossref_metadata_2025_split huggingface dataset:
Centrilobular zonal necrosis is a unique subtype of autoimmune hepatitis A cohort study
Authors: Ueda Kaoru , Aizawa Yoshio , Kinoshita Chika , Nagano Tomohisa , Ishida Jinya , Saeki Chisato , Oikawa Tsunekazu , Harada Toru , Hokari Atsushi , Saruta Masayuki 
Published: February 2020

Abstract
BACKGROUND Centrilobular zonal necrosis (CZN) is advocated as a histological hallmark present in a small number of patients with autoimmune hepatitis (CZN-AIH). Moreover, CZN has been detected in the absence of significant interface hepatitis, one of the most important histological findings of AIH. The concept of CZN-AIH as a distinctive subtype of AIH remains controversial, due to the rarity of CZN-AIH and the ambiguous definition of CZN. To elucidate the clinicopathological and immunogenetic features of CZN-AIH, and to evaluate the significance of co-existent interface hepatitis in CZN-AIH. METHODS A total of 102 biopsy samples of AIH, obtained at The Jikei University Katsushika Medical Center and Jikei University Hospital, were reviewed. The 32 patients whose biopsies showed CZN were selected as the CZN-AIH group and the remaining 70 were grouped as the non-CZN-AIH controls. In the CZN-AIH group, interface hepatitis was histologically present in 37.5% (n=12; mixed-type) and absent in 62.5% (n=20; pure-type). Data on clinical, histopathologic and immunogenetic features were statistically compared between the CZN-AIH group and the non-CZH-AIH controls. Additionally, significance of interface hepatitis in CZN-AIH was determined by comparative analysis of the mixed-type and pure-type subgroups. RESULTS Cases of CZN-AIH were more frequently of acute-onset hepatitis (56.2% vs chronic: 32.9%, P=0.031), lower immunoglobulin G level (P<0.001), lower antinuclear antibodies titer (P<0.001), and lower AIH score (P<0.001). Compared to the non-CZN-AIH cases, the CZN-AIH cases also tended to lack the typical histological characteristics of AIH and of the immunogenetic disproportionate distribution of HLA-DR genotypes in AIH (increased HLA-DR4 and decreased HLA-DR9), and responded more favorably to first-line therapy (P=0.054). For the acute-onset CZN-AIH cases, the clinical and histological features were indistinguishable from the non-acute cases. In contrast, the acute-onset non-CZN-AIH cases were distinguishable from the non-acute cases by lower antinuclear antibodies titer, lower immunoglobulin G level, and less advanced histological stage. The presence of interface hepatitis generally did not influence the morbidity of CZN-AIH, except for comorbid autoimmune diseases, higher gamma-glutamyltranspeptidase level, and increased immunoglobulin M level. CONCLUSION CZN-AIH is clinicopathologically and immunogenetically distinguishable. CZN can characterize a distinct AIH subtype, regardless of onset-pattern or co-existent interface hepatitis.
Distribution of Anopheles species in malaria endemic areas of Honduras in an elimination setting
Authors: Escobar Denis , Ascencio Krisnaya , Ortiz Andrés , Palma Adalid , Fontecha Gustavo 
Published: February 2020

Abstract
Background: Anopheles mosquitoes are the vectors of malaria, one of the most important infectious diseases in the tropics. More than 500 Anopheles species have been described worldwide, and more than 30 are considered a public health problem. In Honduras, information on the distribution of Anopheles spp. and its genetic diversity is scarce. This study aimed to update information on the diversity of Anopheles mosquitoes in Honduras with a morphological and molecular approach. Methods: Mosquitoes were captured in 8 locations in 5 malaria endemic departments during 2019. Two collections methods were used. Adult anophelines were captured outdoors using CDC light traps and by aspiration of mosquitoes at rest. The morphological identification was performed using taxonomic keys. Genetic analyses included the sequencing of a partial region of the cytochrome oxidase I gene (COI) and the ribosomal internal transcribed spacer 2 (ITS2). Results: A total of 1320 anophelines were collected and identified through morphological keys. Seven Anopheles species were identified. An. albimanus was the most widespread and abundant species (74.02%). To confirm the morphological identification of the specimens, 175 and 122 sequences were obtained for COI and ITS2 respectively. Both markers confirmed the morphological identification. COI showed a greater nucleotide diversity than ITS2 in all species. High genetic diversity was observed within the populations of An. albimanus while An. darlingi proved to be a highly homogeneous population. Phylogenetic analyses revealed clustering patterns in An. darlingi and An. neivai in relation to specimens from South America. New sequences for An. crucians, An. vestitipennis, and An. neivai are reported in this study. Conclusions: Here we report the distribution of Anopheles species in endemic areas of malaria in Honduras. According to our results, both taxonomic and molecular approaches are useful tools in the identification of anopheline mosquitoes. However, both molecular markers differ in their ability to detect intraspecific genetic diversity. These results provide supporting data for a better understanding of the distribution of malaria vectors in Honduras.
­Rotavirus group A genotype circulation patterns across Kenya before and after nationwide vaccine introduction, 2010-2018
Authors: Mwanga Mike , Owor Betty , Ocheing John , Ngama Mwanajuma , Ogwel Billy , Onyango Clayton , Juma Jane , Njeru Regina , Gicheru Elijah , Otieno Grieven , Khagayi Sammy , Agoti Charles , Bigogo Godfrey , Omore Richard , Addo Yaw , Mapaseka Seheri , Tate Jacqueline , Parashar Umesh , Hunsperger Elizabeth , Verani Jennifer , Breiman Robert , Nokes James 
Published: February 2020

Abstract
Background: Kenya introduced the monovalent G1P[8] Rotarix® vaccine into the infant immunization schedule in July 2014. We examined trends in rotavirus group A (RVA) genotype distribution pre- (January 2010 - June 2014) and post- (July 2014-December 2018) RVA vaccine introduction.Methods: Stool samples were collected from children aged <13 years from four surveillance sites across Kenya: Kilifi County Hospital, Tabitha Clinic, Lwak Mission Hospital, and Siaya County Referral Hospital (children aged <5 years only). Samples were screened for RVA using enzyme linked immunosorbent assay (ELISA) and G and P genes sequenced to infer genotypes.Results: We genotyped 614 samples in pre-vaccine and 261 in post-vaccine introduction periods. During the pre-vaccine introduction period, the most frequent RVA genotypes were G1P[8] (45.8%), G8P[4] (15.8%), G9P[8] (13.2%), G2P[4] (7.0%) and G3P[6] (3.1%). In the post-vaccine introduction period, the most frequent genotypes were G1P[8] (52.1%), G2P[4] (20.7%) and G3P[8] (16.1%). Predominant genotypes varied by year and site in both pre and post-vaccine periods. Temporal genotype patterns showed an increase in prevalence of heterotypic commonly DS-1-like G2P[4] (7.0 to 20.7%, P <.001) and G3P[8] (1.3 to 16.1%, P< .001) genotypes in the post-vaccine introduction period. Additionally, we observed a decline in prevalence of genotypes G8P[4] (15.8 to 0.4%, P <.001) and G9P[8] (13.2 to 5.4%, P <.001) in the post-vaccine introduction period.Conclusion: Genotype prevalence varied from before to after vaccine introduction. Such observations emphasize the need for long-term surveillance to monitor vaccine impact. These changes may represent natural secular variation or possible immuno-epidemiological changes arising from the introduction of the vaccine. Full length sequencing could provide insights into post-vaccine evolutionary pressures and antigenic diversity.
Changes in choroidal thickness in advanced diabetic retinopathy treated with pan-retinal photocoagulation using a pattern scanning laser versus a conventional laser
Authors: Park Nari , Lee In Gul , Kim Jee Taek 
Published: February 2020

Abstract
Background : To compare the effect of pan-retinal photocoagulation (PRP) using pattern scanning or conventional laser on subfoveal choroidal thickness (SFChT).
Methods : Thirty-eight patients (64 eyes) with advanced diabetic retinopathy (DR) who underwent PRP using pattern scanning or conventional laser were included. Changes in SFChT were compared with baseline values at 1, 3, 6, and 12 months after PRP using swept-source optical coherence tomography.
Results : The conventional laser group showed statistically significant decrease in SFChT at 1, 3, 6, and 12 months after PRP ( P <0.001). SFChT was significantly decreased at 3 ( P = 0.025), 6 ( P = 0.004), and 12 months ( P < 0.001) after treatment in the pattern laser group.
Conclusion : Eyes with advanced DR showed a significant reduction in SFChT over 12 months regardless of the type of laser used; however, the reduction was sooner after conventional laser than after pattern laser.
Tracing the Decisions That Shaped the Development of MyChart, an Electronic Patient Portal in Alberta, Canada: Historical Research Study
Authors: Avdagovska Melita , Stafinski Tania , Ballermann Mark , Menon Devidas , Olson Karin , Paul Pauline 
Published: February 2020

Background
Understanding how health organizations decide on information technology (IT) investments is imperative to ensure successful implementation and adoption. There is a high rate of failure and a tendency to downplay the complexity of implementation progression. Alberta Health Services introduced a patient portal called MyChart. Although MyChart allows patients to view appointments and selected laboratory results and to communicate with their providers, its uptake varies.

Objective
The study aimed to examine the institutional decision-making processes that shaped the development and implementation of MyChart.

Methods
A historical study was conducted based on the 7-step framework, where one engages in a rigorous archival critical analysis (including internal and external criticism) of documents and analysis of interviews. We reviewed and analyzed 423 primary and secondary sources and interviewed 10 key decision makers.

Results
Supportive leadership, project management, focused scope, appropriate technology and vendor selection, and quick decision making were some of the facilitators that allowed for the growth of proof of concept. The planning and implementation stages did not depend much on the technology itself but on the various actors who influenced the implementation by exerting power. The main barriers were lack of awareness about the technology, proper training, buy-in from diverse system leaders, and centralized government decision making.

Conclusions
Organizational priorities and decision-making tactics influence IT investments, implementation, adoption, and outcomes. Future research could focus on improving the applicability of needs assessments and funding decisions to health care scenarios.
Involvement of People With Dementia in the Development of Technology-Based Interventions: Narrative Synthesis Review and Best Practice Guidelines
Authors: Rai Harleen Kaur , Cavalcanti Barroso Aline , Yates Lauren , Schneider Justine , Orrell Martin 
Published: February 2020

Background
Technology can be helpful in supporting people with dementia in their daily lives. However, people with dementia are often not fully involved in the development process of new technology. This lack of involvement of people with dementia in developing technology-based interventions can lead to the implementation of faulty and less suitable technology.

Objective
This systematic review aims to evaluate current approaches and create best practice guidelines for involving people with dementia in developing technology-based interventions.

Methods
A systematic search was conducted in January 2019 in the following databases: EMBASE (Excerpta Medica database), PsycINFO, MEDLINE (Medical Literature Analysis and Retrieval System Online), CINAHL (Cumulated Index to Nursing and Allied Health Literature), and Web of Science. The search strategy included search terms in 3 categories: dementia, technology, and involvement in development. Narrative synthesis wove the evidence together in a structured approach.

Results
A total of 21 studies met the inclusion criteria. Most studies involved people with dementia in a single phase, such as development (n=10), feasibility and piloting (n=7), or evaluation (n=1). Only 3 studies described involvement in multiple phases. Frequently used methods for assessing involvement included focus groups, interviews, observations, and user tests.

Conclusions
Most studies concluded that it was both necessary and feasible to involve people with dementia, which can be optimized by having the right prerequisites in place, ensuring that technology meets standards of reliability and stability, and providing a positive research experience for participants. Best practice guidelines for the involvement of people with dementia in developing technology-based interventions are described.
The development of Kolb Learning Style and 4c's 21st century skill integration e-book in Pedagogy Subject
Authors: Santika Tiara , Ganefri Ganefri , Jalinus Nizwardi , Syahril Syahril , Rizal Fahmi , Sukardi Sukardi , Rispendra Rispendra , Nabawi Rahmat Azis 
Published: February 2020

This research was based on the demands of the 21st century in which teachers should have 4 skills (critical thinking, creativity, collaboration, and communication). Teachers are required to change the way of teaching that initially (teacher-centered) turns into (student-centered) and able to participate to follow the development of technology. Therefore, E-book learning is needed that can present material pedagogy integrated with kolb learning and 4C's. This research aims to produce the final product in the form of valid e-book media learning, practical and effective in pedagogy subject. This was a research and development (Research and Development) research. This development research used ADDIE development model consisting of 5 stages which were Analysis, Design, Development, Implementation and Evaluation). Based on the results, e-book validation testing conducted by three validators, it obtained Aiken's score 0.9 with a valid category. The test results practicalities of the teachers and the students were 86% in the practical category. The effectiveness test results was 89.65%. Thus, it can be concluded that this research has produced a pedagogical e-book which is valid, practical and effective.
Implikasi Erupsi Gunung Agung Terhadap Usaha Pariwisata Di Daya Tarik Wisata Bahari Tulamben, Kecamatan Kubu, Kabupaten Karangasem
Authors: Putri Ida Ayu Karina , Adikampana I Made 
Published: February 2020

Tulamben Marine Tourist Attraction it has a variety of tourism business such as, tourist accommodations, diving and snorkeling occupations, porter professions also food and beverage services. Mount Agung status alert, on October 22nd, 2017 some residents within radius of 12 km are evacuated to several areas in Bali. The evacuated people are living in 28 villages in Karangasem regency, one of them is Tulamben Village. Mount Agung eruption has a direct impact on tourism bussiness. This study aims to analyze the implication of Mount Agung Eruption on Tourism Business at Tulamben Marine Attraction, Kubu Sub-District, Karangasem Regency. The research method used is qualitative study with descriptive analysis technique to examine the implications of Mount Agung eruption on tourism business. Source data from primary knowledges and secondary documents. Data are collected through observation methods, interviews, literature study, and research instruments in the form of interview guidelines. The informants are determinated by using purposive sampling technique to obtain accurate data about the type of tourism business and the implications of eruption of Mount Agung to the tourism business service in Tulamben Marine Tourist Attraction.
Keywords: Marine Tourist Atrraction, Eruption, and Tourism Bussines
Analisis Peran Stakeholder Desa Wisata Carangsari, Kecamatan Petang, Kabupaten Badung
Authors: Cahyana Shafa Raya , Nugroho Saptono 
Published: February 2020

Carangsari tourism Village is one of the tourist villages in Badung Regency, with various natural and cultural potentials. This study aims to determine the role of the three pillars of tourism in carrying out its right and responsibilitiestowards of Carangsari Tourism Village.The metode used in this study is a qualitative method with qualitative descriptive techniques understand the role of stakeholders in Carangsari Tourism Village, Petang District, Badung Regency. Used some sources of data including primary data and secondary data. The collection data technique, in this study, is using observation, interviews, library studies, and several interviewguidance instrument. Determination of informant in the study of the role of stakeholder in Carangsari Tourism Village used purposive sampling to obtain accurate data on the role of three tourism pillar actor on management in Carangsari Tourism Village, Petang District, Badung Regency. The results of this study obtained the active aspectf, status, right, and
obligation Carangsari Tourism Village, Petang District, Badung Regency.Keywords: Stakeholder, Role, Village Tourism, and Badung.
ANALISIS RISIKO PAJANAN NH3 DAN H2S TERHADAP GANGGUAN PERNAPASAN PADA PENDUDUK DI SEKITAR TEMPAT PEMBUANGAN AKHIR SAMPAH BUKIT PINANG SAMARINDA
Authors: Firdaus Ade Rahmat 
Published: February 2020

The air pollution in the garbage dump gave the bad effect for the environmental health , NH3, H2S and the other polluted gases were the causes of air pollution that could give the bad effect for health, especially respiratory disorders. The garbage dump of bukit pinang was located in samarinda and still used open dumping method that could cause environmental pollution. Research design used cross sectional approach. The sample of NH3 and H2S was taken at 3 points and there were 34 respondents that were chosen using purposive sampling. Data collection included in the measurement of NH3 and H2S, interview, and observation of respiratory disorders. Data analysis used t-independent test with 95% of confidence level.Result of the study showed that the concentration of NH3 and H2S at garbage dump of Bukit Pinang at sample points I, II, and III was still under quality standard. Result of T - Independent showed that there was relationship among concentration of NH3 (?-value= 0,005), concentration H2S (?-value=0,042), exposure period of NH3 and H2S (?-value=0,000), and Risk Quotient NH3 (?-value=0,000), H2S (?-value=0,000) with the respiratory disorders of the people around the garbage dump of bukit pinang. Result of Mann-Whitney test showed that there was no relationship between exposure frequency of NH3 and H2S (?-value=0,284) with the respiratory disorders of the people around the garbage dump of bukit pinang
ANALISIS FAKTOR YANG BERHUBUNGAN DENGAN KUNJUNGAN NEONATAL DI PUSKESMAS KAMPUNG BAQA SAMARINDA TAHUN 2018
Authors: Salasiah Siti 
Published: February 2020

At the age of less than 28 days newborns are very span to death, so at this time need to be aware of some signs and dangers in the newborn. One of the efforts undertaken to reduce the infant mortality rate is neonatal visits conducted in health services. This study aims to determine several factors related to Neonatal Visits (KN) in the work area of Puskesmas Kampung Baqa in 2018. This study uses Analytical Survey, with cross sectional approach. Respondents of this study were all mothers who had babies aged 0-28 days as many as 87 respondents with sampling techniques using puposive sampling. Data analysis performed was univariate and bivariate with Chi-Square test. The results of this study found that all the variables studied were associated with neonatal visits in the work area of Puskesmas Kampung Baqa in 2018, namely knowledge (p value 0,000), attitude (p value 0,000) and family support (p value 0,006). The conclusion in this research is that knowledge, attitude, and support of mother's family can influence visit of neonatal mother to conduct Neonatal Visit (KN). Therefore, it is necessary to be counseled about the importance of conducting neonatal visits to the public by health workers intensively so that the knowledge of the community especially the mothers who have babies 0-28 days to increase. Keywords : Visit Neonatal, Knowledge, Attitude, Family SupportBibliograpy : 25 (1991-2017).
Detection of Anomalies in the Computer Network Behaviour
Authors: Protić Danijela , Stanković Miomir 
Published: February 2020

Abstract
The goal of anomaly-based intrusion detection is to build a system which monitors computer network behaviour and generates alerts if either a known attack or an anomaly is detected. Anomaly-based intrusion detection system detects intrusions based on a reference model which identifies normal behaviour of the computer network and flags an anomaly. Basic challenges in anomaly-based detection are difficulties to identify a ‘normal’ network behaviour and complexity of the dataset needed to train the intrusion detection system. Supervised machine learning can be used to train the binary classifiers in order to recognize the notion of normality. In this paper we present an algorithm for feature selection and instances normalization which reduces the Kyoto 2006+ dataset in order to increase accuracy and decrease time for training, testing and validating intrusion detection systems based on five models: k-Nearest Neighbour (k-NN), weighted k-NN (wk-NN), Support Vector Machine (SVM), Decision Tree, and Feedforward Neural Network (FNN).
Correlations between the Hysteresis Parameters Determining the Rolling Resistance in Rubber Composites
Authors: Xu T.-W. , Jia Z.-X. , Chen Y.-J. , Jia D.-M. , Wang Y.-Q. 
Published: February 2020

Abstract
Recently, the research on low rolling resistance tires attracted interest for its reduction of petrol consumption, which is related to the hysteresis loss of rubber composites. Here, four common methods representing the hysteresis loss of rubber composites in lab were contrasted to explore the potential connections between them. The results indicated that tan δ obtained by DMA showed good positive linearity with that obtained by RPA without distinguishing the rubber species and filler types, also for the positive relation between tan δ and hysteresis loop area (HLA). The rolling power loss (L) captured by the rolling resistance testing machine appeared to have a positive correlation with tan δ from DMA or RPA in NR composites, while a negative connection showed up in SBR composites. Further, considering the influence of strain on rolling energy loss, the 100% modulus was introduced leading to a good positive quadratic equation connection between tan δ/100% modulus and L in all common rubber composites.