bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing tolerability with the Functional Assessment of Cancer Therapy item GP5: psychometric evidence from LIBRETTO-531, a phase 3 trial of selpercatinib in medullary thyroid cancer
Authors: Regnault Antoine , Bunod Laurine , Loubert Angely , Brose Marcia S. , Hess Lisa M. , Maeda Patricia , Lin Yan , Speck Rebecca M. , Gilligan Adrienne M. , Payakachat Nalin 
Published: December 2024

Abstract
Background
This psychometric analysis generated evidence to support the use of the Functional Assessment of Cancer Therapy item GP5 (GP5) as a measure of tolerability and confirms the appropriateness of categorizing “high side-effect burden” using a rating of 3 or 4 (score ranges 0–4) in patients with advanced/metastatic RET-mutant medullary thyroid cancer (MTC).

Methodology
Blinded, pooled interim data from the safety population (n=290) enrolled in the phase 3 LIBRETTO-531 trial (NCT04211337) were used. Intraclass correlation coefficients (ICC) were calculated for test-retest reliability using data from cycles 1-2 post-baseline. Construct validity was evaluated by examining the correlations of GP5 ratings with (a) symptomatic adverse events (AEs; measured by the PRO-CTCAE), and (b) functioning scores of EORTC QLQ-C30. The ability to detect change over time was examined by Cochrane-Mantel-Haenszel tests for GP5 ratings and PRO-CTCAE. The relationship of “high side-effect burden” categories with QLQ-C30 functioning scores was examined.

Results
ICCs for the GP5 ratings after cycle 1 ranged between 0.80 and 0.85, indicating good reliability. Correlations between GP5 and PRO-CTCAE items ranged from 0.18 to 0.62 and ranged from -0.37 to -0.50 for QLQ-C30 functioning scores, consistent with study assumptions. Post-baseline GP5 ratings showed significant associations with PRO-CTCAE scores (p<0.001). Participants with GP5 ratings of 3 or 4 had worse physical function than those with GP5 ratings of 0 to 2 (p<0.0001).

Conclusions
This analysis generated evidence supportive of the psychometric properties of the GP5 as a fit-for-purpose measure to assess treatment tolerability in patients with advanced/metastatic MTC. The definition of “high side-effect burden” was associated with the clinical feature of tolerability.
Effect of tacrolimus with mycophenolate mofetil or cyclophosphamide on the renal response in systemic lupus erythematosus patients
Authors: Sun Siqin , Zhang Xueyi , Guo Qingqing , Tang Xiaojun , Shen Wei , Liang Jun , Yao Genhong , Geng Linyu , Ding Shuai , Chen Hongwei , Wang Hong , Hua Bingzhu , Zhang Huayong , Feng Xuebing , Jin Ziyi , Sun Lingyun 
Published: December 2024

Abstract
Objective
This study aimed to determine the therapeutic efficacy of tacrolimus (TAC) with mycophenolate mofetil (MMF) or cyclophosphamide (CYC) on the renal response in systemic lupus erythematosus (SLE) patients.

Methods
A retrospective cohort study based on medical data was conducted among SLE patients who took at least one of the following medicines in 2010–2021: TAC, MMF and CYC. The odds ratio (OR) and 95% confidence interval (CI) were calculated, and the synergistic interaction was estimated using logistic regression models.

Results
Among 793 SLE patients, 27.9% patients (221 cases) achieved CR after at least 3 months. The TAC use was positively associated with CR with an adjusted OR (95% CI) of 2.82 (1.89, 4.22) overall and in subgroups of SLE patients with SLEDAI scores > 12, moderate or severe urinary protein and comorbidities. The dose-response effect on CR was also observed at TAC doses greater than 4 mg/d and more than 180 days, with adjusted ORs (95% CIs) of 5.65 (2.35, 13.55) and 3.60 (2.02, 6.41), respectively. Moreover, the combined effect of TAC with MMF or CYC was better than that of monotherapy, there was significant synergistic interactions with adjusted ORs (95% CIs) of 2.43 (1.20, 4.92) and 3.14 (1.49, 6.64), respectively, and similar results were observed for the combination of different doses of TAC with MMF or CYC.

Conclusion
TAC can effectively alleviate the condition of patients with SLE and may interact with MMF or CYC, which suggests that the combination therapy of TAC with MMF or CYC may produce greater benefits for patients with SLE.

Trial registration
This is a purely observational study that does not require registration.
Insecticidal potential of botanical extracts for management of, the oriental fruit fly, Bactrocera dorsalis (Diptera: Tephritidae)
Authors: Akram Wasim , Hussain Azhar , Abbas Qamar , Abbas Aqleem 
Published: December 2024

Abstract
Background
Bactrocera dorsalis (Hendel) poses a significant threat to global fruit production and quality, including in Pakistan, where it causes substantial losses. Traditional control methods have heavily relied on the indiscriminate and imprudent use of insecticides, leading to challenges such as insecticide resistance, environmental pollution, fruit contamination, and health risks. This study explores the insecticidal potential of seven selected botanicals: Artemisia vulgaris L., Capparis spinosa L., Mentha longifolia, Mentha piperita, Peganum harmala, Eucalyptus globulus, and Callistemon viminalis, each at three different concentrations (10mL, 20mL, and 30mL), against Bactrocera dorsalis (B. dorsalis). Two in vitro experiments involving the application of plant extracts mixed with protein bait and direct spray were conducted.

Results
Both experimental results demonstrated a direct correlation between the concentration of plant extract and the mortality of B. dorsalis. In the plant extract mixed with protein bait, results recorded after 96 h at 10 mL ranged from 8.667 ± 1.52–47.000 ± 3.00, at 20 mL from 18.667 ± 1.52–53.667 ± 6.02, and 30 mL from 26.000 ± 5.29- 67.667 ± 2.08. Meanwhile, for direct spray, mortality ranged from 2.333 ± 1.15–32.333 ± 6.80 at 10 mL, 1.000 ± 1.00–42.667 ± 7.02 at 20 mL, and 9.667 ± 2.30–61.333 ± 8.50 at 30 mL, respectively. The plant species exhibiting the highest toxic potential against the respective pests was C. viminalis, followed by A. vulgaris L. In contrast, the least toxic effect was observed in Eucalyptus globulus at all concentrations. The highest mean mortality and repellence % were recorded in C. viminalis and E. globulus in both experimental trials. The results revealed the highest efficacy of C. viminalis with an LC50 value of 9685.15 and 19,909.11 ppm, for the extract mixed with protein bait and sprayed, was obtained, respectively, the most toxic to the pest followed by the extracts E. globulus and C. spinosa L.

Conclusion
Based on our experimental results, it is concluded that C. viminalis and A. vulgaris L. are an effective alternative for the management of B. dorsalis.
Risk factors and comorbidities associated with cardiac arrests and medical emergencies in interventional radiology patients
Authors: AlHarbi Husam Mohammed , Arabi Tarek , Alduribi Yasser Saleh A. , Shah Hassan , Sabbah Ahmad , Othman Khalid , Bashir Omar , Arabi Mohammad 
Published: December 2024

Abstract
Purpose
To investigate the incidence, predictors, and outcomes of medical emergencies in patients undergoing IR procedures at a tertiary care center.

Materials and methods
Seven-year retrospective review of all medical emergencies in patients undergoing IR procedures at King Abdulaziz Medical City, Riyadh, Saudi Arabia. Medical emergencies included Cardiopulmonary arrest (CPA), or emergencies that required activation of the critical care response team (CCRT). Variables included demographics, procedure details and outcome data including complications and 30-day mortality. Multivariate logistic regression analysis was conducted to identify independent predictors of CPA and 30-day mortality.

Results
Ninety-four patients (50% male) were included with a median age of 60.5 years. Recent or current ICU admission was recorded in 39 patients (43.8%). Comorbidities included diabetes (50%), hypertension (59.6%), coronary artery disease (25.5%), heart failure (21.5%), ESRD (28.7%), active infection 28 (31%), with ASA3 in 64 patients (68%) and ASA4 in 23 (24.5%).
The incidence of CPA and CCRT activation was 0.045% and 0.049%, respectively, among 100,000 patients who underwent IR procedures during the study period. Half the events were with venous procedures, followed by non-vascular (33%) and arterial procedures (10.6%). 30-day mortality was 30.5%. Independent predictors of CPA included pulmonary disease (aOR 16.79, 95% CI 2.334–195.3, p = 0.0097), emergency procedures (aOR 11.63, 95% CI 2.517–72.46, p = 0.0035), general anesthesia (aOR 19.41, 95% CI 1.854–491.8, p = 0.0254), and sedation (aOR 13.04, 95% CI 2.081–118.8, p = 0.0108). Predictors of 30-day mortality were CPA (aOR 9.830, 95% CI 2.439–66.66, p = 0.0045) and hypotension as a complication (aOR 16.81, 95% CI 3.766–122.3, p = 0.0009).

Conclusion
Our findings highlight the complexity of patients undergoing IR procedures and the importance of identifying high-risk patients to prevent adverse events in the IR setting.
Aggravated liver steatosis in a modern dietary mouse model via long-term treatment of SiO2 nanoparticles in drinking water
Authors: Ye Tzung Cheng , Chao Shu-Ju , Huang Chihpin , Mai Ru-Tsun 
Published: December 2024

AbstractSiO2 nanoparticles (SNPs), which are abundant in water and are used for various applications, for example, as food additives and anticaking agents, are of growing concern because of rising exposure to human health. Research has reported low potential side effects in animal models treated with SNPs; however, a few in vivo studies have shown cause for concern. Presently, high-fat foods have changed our lives and increased the incidence rates of fatty liver, obesity, and overweight, and high-fat foods issue is prevalent in our modern society. To understand the rising SNPs exposure in life and modern dietary habits combined effect, we design experiments to study this research. Institute of Cancer Research mice fed a normal or high-fat diet were treated with different concentrations of SNPs for long-term effects. Blood and liver tissue were collected and prepared for blood biochemical assays, histology analysis, silicon and triglycerides (TGs) accumulation, immunohistochemistry, fibrosis staining, and terminal deoxynucleotidyl transferase dUTP nick-end labeling staining to analyze the influence of the combination of SNPs and a high-fat diet. This research found that the presence of SNPs in drinking water with the consumption of a high-fat diet was associated with the accumulation of SNPs and TGs in liver tissue, elevated aspartate aminotransferase and alanine aminotransferase levels in serum, activation of fibrosis and inflammation, increased oxidative stress through 4-hydroxynonenal, and the development of liver steatosis. The results showed that the long-term effect of SNPs in drinking water might induce liver steatosis, particularly under modern dietary habits such as a high-fat diet. This study investigated the interactions between environmental nanoparticles, such as the long-term risk of exposure to SNPs, and dietary factors, suggesting a significant risk to liver health, especially in human health.
A conceptual modeling approach of MQTT for IoT-based systems
Authors: Mohammad El-Basioni Basma M. 
Published: December 2024

AbstractThe Message Queuing Telemetry Transport (MQTT) is one of the most commonly used standard messaging protocols that enable the Internet of Things (IoT). The messaging standard specification document defines the transactions, attributes, conventions, timers, values, types, structures, etc. MQTT encounters wide implementation possibilities: hardware vendors need to implement MQTT drivers for their devices, software vendors need to implement it in their solutions, developers and researchers need an MQTT simulation framework, etc. The IoT technology can enable unlimited number of use cases, and each case has its implementation of the messaging protocol. From the above facts, on the basis that any user needs to have a deep understanding of the specification in order to implement the protocol and also developers need to study it well for improving the protocol, there is a need for a standard conceptual way that conveys the messaging standard specifications, integrates the specifications of the use cases built upon with a more abstracted mental representation, improves the communication between developers, and facilitates the protocols and applications developments. This paper addresses this issue by proposing a graphical conceptual modeling approach for MQTT-based IoT applications called Example-oriented System Conceptual Modeling for MQTT use cases (EoSCM-MQTT). The paper explains the EoSCM-MQTT and gives an example of its use in an MQTT simulation implementation for a specific IoT application: smart parking. EoSCM-MQTT was validated using three methods: comparison, analysis, and implementation. The details and results of the implementation and the conclusions from the comparison and analysis indicated that EoSCM-MQTT has the required characteristics of conceptual models: good syntactic semantic, and pragmatic quality, clarity, coherence, accuracy, flexibility, reliability, and effectiveness.
From propensity to action: exploring gender and cognitive influences on Informal Investment Intentions
Authors: Singh Vandana , Khan Nawab Ali , Bhat Mohd Nadeem 
Published: December 2024

AbstractThis study explores the factors influencing Informal Investment Intentions among potential investors, focusing on Risk Propensity and Subjective Norms. It examines the mediating effect of Entrepreneurial Alertness and the moderating role of gender, aiming to understand how these elements shape investment decisions among management students in India. A survey-based cross-sectional research design is followed to evaluate a 340 cross-sectional sample. Global Entrepreneurship Monitor (GEM) database, SEM, and the PROCESS macro have been utilized to understand the synchronization between the variables. CFA, RMSEA, GFI, and TLI tests are employed to check the fitness and validity of the model, and CMB, together with PFA, have been applied for variance testing. The study found that Subjective Norms significantly influence Informal Investment Intentions, mediated by Entrepreneurial Alertness. Gender exuberates the relationship between Risk Propensity and Informal Investment Intentions through Self-Efficacy, with stronger effects observed among male students. Findings offer insights for policymakers and educators to design interventions fostering Informal Investment Intentions by enhancing Entrepreneurial Alertness and addressing gender-specific differences, particularly among management students. This study adds to the literature by examining gender's moderating role in the relationship between Risk Propensity and Informal Investment Intentions, providing a nuanced understanding of informal investment behavior in an Indian context.
Autoimmune mechanisms in Guillain-Barré syndrome subtypes: a systematic review
Authors: Oshomoji O. I. , Ajiroba J. O. , Semudara S. O. , Olayemi M. A. , Adeoye S. O. 
Published: December 2024

Abstract
Guillain-Barré syndrome (GBS) is a complex autoimmune disorder characterized by acute onset of motor weakness, often following an infectious illness. The pathophysiology of GBS involves a multifaceted interplay between immune mechanisms and environmental factors, leading to demyelination or axonal degeneration. This systematic review aims to elucidate the autoimmune mechanisms underlying the various subtypes of GBS, including acute inflammatory demyelinating polyneuropathy (AIDP), acute motor axonal neuropathy (AMAN), acute motor and sensory axonal neuropathy (AMSAN), and Miller Fisher syndrome (MFS). A thorough literature search identified 71 studies published between 2010 and 2024 that provided insights into the immunopathological features, clinical implications, and future directions for research. Key findings indicate that specific autoantibodies, such as anti-GM1 and anti-GQ1b, are associated with distinct subtypes of GBS, contributing to the disease’s heterogeneity. Understanding these autoimmune mechanisms is crucial for improving diagnostic accuracy, therapeutic strategies, and prognostic indicators in GBS. This review highlights significant gaps in current research, emphasizing the need for further studies to explore the genetic and environmental factors that influence GBS susceptibility and the role of vaccinations in triggering autoimmune responses.

Trial registration
PROSPERO CRD42024606718.
DeepDoublet identifies neighboring cell-dependent gene expression
Authors: Liao Linbu , Kim Junyoung , Cho Kanghee , Kim Junil , Lim Byung-Kwan , Won Kyoung Jae 
Published: December 2024

AbstractCells interact with each other for proper function and homeostasis. Often, co-expression of ligand-receptor pairs from the single-cell RNAseq (scRNAseq) has been used to identify interacting cell types. Recently, RNA sequencing of physically interacting multi-cells has been used to identify interacting cell types without relying on co-expression of ligand-receptor pairs. This opens a new avenue to study the expression of interacting cell types. We present DeepDoublet, a deep-learning-based tool to decompose the transcriptome of physically interacting two cells (or doublet) into two sets of transcriptome. Applying DeepDoublet to the doublets of hepatocyte and liver endothelial cells (LECs), we successfully decomposed into the transcriptome of each cell type. Especially, DeepDoublet identified specific expression of hepatocytes when they are interacting with LECs. Among them was Angptl3 which has a role in blood vessel formation. DeepDoublet is a tool to identify neighboring cell-dependent gene expression.
Long-term ambient air pollution and the risk of major mental disorder: A prospective cohort study
Authors: Pan Chuyu , Cheng Bolun , Cheng Shiqiang , Liu Li , Yang Xuena , Meng Peilin , Qi Xin , Zhang Na , Qin Xiaoyue , He Dan , Wei Wenming , Hui Jingni , Wen Yan , Jia Yumeng , Liu Huan , Zhang Feng 
Published: December 2024

Abstract

Background
Despite growing awareness of the mental health damage caused by air pollution, the epidemiologic evidence on impact of air pollutants on major mental disorders (MDs) remains limited. We aim to explore the impact of various air pollutants on the risk of major MD.

Methods
This prospective study analyzed data from 170 369 participants without depression, anxiety, bipolar disorder, and schizophrenia at baseline. The concentrations of particulate matter with aerodynamic diameter ≤ 2.5 μm (PM2.5), particulate matter with aerodynamic diameter > 2.5 μm, and ≤ 10 μm (PM2.5–10), nitrogen dioxide (NO2), and nitric oxide (NO) were estimated using land-use regression models. The association between air pollutants and incident MD was investigated by Cox proportional hazard model.

Results
During a median follow-up of 10.6 years, 9 004 participants developed MD. Exposure to air pollution in the highest quartile significantly increased the risk of MD compared with the lowest quartile: PM2.5 (hazard ratio [HR]: 1.16, 95% CI: 1.09–1.23), NO2 (HR: 1.12, 95% CI: 1.05–1.19), and NO (HR: 1.10, 95% CI: 1.03–1.17). Subgroup analysis showed that participants with lower income were more likely to experience MD when exposed to air pollution. We also observed joint effects of socioeconomic status or genetic risk with air pollution on the MD risk. For instance, the HR of individuals with the highest genetic risk and highest quartiles of PM2.5 was 1.63 (95% CI: 1.46–1.81) compared to those with the lowest genetic risk and lowest quartiles of PM2.5.

Conclusions
Our findings highlight the importance of air pollution control in alleviating the burden of MD.
Anisotropic plasmons in threefold Hopf semimetals
Authors: Ahn Seongjin 
Published: December 2024

Abstract
Threefold Hopf semimetals are a novel type of topological semimetals that possess an internal anisotropy characterized by a dipolar structure of the Berry curvature and an isotropic energy band structure consisting of a Dirac cone and a flat band. In this study, we theoretically investigate the impact of internal anisotropy on plasmons in threefold Hopf semimetals using random-phase approximation. In contrast to the classical intuition that isotropy of the energy band dispersion leads to isotropic plasmons in the classical regime (i.e., in the wavelength limit), we find that plasmons in threefold Hopf semimetals exhibit notable anisotropy even in the long-wavelength limit. We derive an explicit analytical form of the long-wavelength plasmon frequency, and numerically demonstrate the validity of our results in a wide range of situations. Our work reveals that the anisotropy of long-wavelength plasmons can reach 25%, making it experimentally observable.
CD34+ Orbital Fibroblasts Contribute to the Pathogenesis of Thyroid Eye Disease via miR-182-5p
Authors: Yu Baiguang , Wang Yi , Jin Jun , Liu Jin , Huang Yazhuo , Wang Yang , Zhu Chenfang , Li Yinwei , Li Bin , Sun Jing , Li Dan , Fang Sijie , Zhou Huifang 
Published: December 2024

Abstract

Context
CD34+ orbital fibroblasts (OFs) play a pathogenic role in thyroid eye disease (TED). Several micro (mi)RNAs have been shown to promote TED progression.

Objective
This study aims to explore the regulatory effects of miRNAs on CD34+ OFs and to find potential therapeutic targets.

Methods
In this case-control study, orbital connective tissues (OCTs) and OFs were obtained from 25 TED patients and 24 healthy donors. MiRNA-seq was performed to examine differential expression of miRNAs in OCTs, and miR-182-5p was selected for subsequent experiments. MiR-182-5p was detected both in CD34+ and CD34− OFs. The upstream regulators of miR-182-5p were studied. Downstream targets of miR-182-5p were analyzed. The functionality of miR-182-5p in CD34+ OFs was evaluated.

Results
MiR-182-5p was highly expressed in TED OCTs and their derived CD34+ OFs. TED OCTs displayed increased expression of interleukin (IL)-6, IL-17A, CD34, and phosphorylated STAT3 at Ser727 and Tyr705. Activation of IL-6/STAT3 signaling promoted the expression of miR-182-5p in CD34+ OFs. MiR-182-5p enhanced wound repair ability, proliferation, and RANTES expression while inhibiting apoptosis in CD34+ OFs. CD34+ OFs transfected with miR-182-5p were susceptible to TGF-β-initiated myofibroblast differentiation. Luciferase reporter and pull-down assays revealed Smad7 as the downstream target of miR-182-5p, which modulated the proliferation, migration, fibrosis, and apoptosis of CD34+ OFs.

Conclusion
The IL-6/STAT3/miR-182-5p pathway led to activation of CD34+ OFs. MiR-182-5p promoted the proliferation, migration, fibrosis, and anti-apoptosis of CD34+ OFs via targeting Smad7. Our findings suggest that miR-182-5p may potentially serve as a therapeutic target for TED.