bluuebunny/crossref_metadata_2025_split huggingface dataset:
Auxetic two-dimensional transition metal selenides and halides
Authors: Pan Jinbo , Zhang Yan-Fang , Zhang Jingda , Banjade Huta , Yu Jie , Yu Liping , Du Shixuan , Ruzsinszky Adrienn , Hu Zhenpeng , Yan Qimin 
Published: October 2020

AbstractAuxetic two-dimensional (2D) materials provide a promising platform for biomedicine, sensors, and many other applications at the nanoscale. In this work, utilizing a hypothesis-based data-driven approache, we identify multiple materials with remarkable in-plane auxetic behavior in a family of buckled monolayer 2D materials. These materials are transition metal selenides and transition metal halides with the stoichiometry MX (M = V, Cr, Mn, Fe, Co, Cu, Zn, Ag, and X = Se, Cl, Br, I). First-principles calculations reveal that the desirable auxetic behavior of these 2D compounds originates from the interplay between the buckled 2D structure and the weak metal–metal interaction determined by their electronic structures. We observe that the Poisson’s ratio is sensitive to magnetic order and the amount of uniaxial stress applied. A transition from positive Poisson’s ratio (PPR) to negative Poisson’s ratio (NPR) for a subgroup of MX compounds under large uniaxial stress is predicted. The work provides a guideline for the future design of 2D auxetic materials at the nanoscale.
On the mechanistic origins of maximum strength in nanocrystalline metals
Authors: Gupta Ankit , Gruber Jacob , Rajaram Satish S. , Thompson Gregory B. , McDowell David L. , Tucker Garritt J. 
Published: October 2020

AbstractThe maximum strength of polycrystalline metals/alloys has been suggested to occur at nanoscale grain sizes where the governing deformation mechanism transitions from dislocation plasticity to grain boundary mediated deformation. Despite tremendous progress recently uncovering links between transitions in nanoscale mechanisms and peak strength, the scientific literature is mostly devoid of any quantitative support, owing to the difficulty in measuring the resolved contribution of individual mechanisms to microstructural strain accommodation. In this study, the contribution of individual nanoscale mechanisms to the overall deformation of nanocrystalline Ni is calculated from atomistic simulations leveraging continuum-based kinematic metrics to compute mechanistic contributions to microstructural strain. By employing such a quantitative approach to analyze deformation behavior, it is shown that the realization of maximum strength in nanocrystalline metals corresponds to a grain size regime where the operative nanoscale mechanisms transition, and are thus equally competing to accommodate strain. However, the transition occurs between intergranular and intragranular mediated mechanisms, as it is found that dislocation plasticity alone is not the governing mechanism at all grain sizes above the peak strength regime.
Coulomb blockade effects in a topological insulator grown on a high-Tc cuprate superconductor
Authors: Rachmilowitz Bryan , Zhao He , Ren Zheng , Li Hong , Thomas Konrad H. , Marangola John , Gao Shang , Schneeloch John , Zhong Ruidan , Gu Genda , Flindt Christian , Zeljkovic Ilija 
Published: October 2020

AbstractThe evidence for proximity-induced superconductivity in heterostructures of topological insulators and high-Tc cuprates has been intensely debated. We use molecular-beam epitaxy to grow thin films of topological insulator Bi2Te3 on a cuprate Bi2Sr2CaCu2O8+x, and study the surface of Bi2Te3 using low-temperature scanning tunneling microscopy and spectroscopy. In few unit-cell thick Bi2Te3 films, we find a V-shaped gap-like feature at the Fermi energy in dI/dV spectra. By reducing the coverage of Bi2Te3 films to create nanoscale islands, we discover that this spectral feature dramatically evolves into a much larger hard gap, which can be understood as a Coulomb blockade gap. This conclusion is supported by the evolution of dI/dV spectra with the lateral size of Bi2Te3 islands, as well as by topographic measurements that show an additional barrier separating Bi2Te3 and Bi2Sr2CaCu2O8+x. We conclude that the prominent gap-like feature in dI/dV spectra in Bi2Te3 films is not a proximity-induced superconducting gap. Instead, it can be explained by Coulomb blockade effects, which take into account additional resistive and capacitive coupling at the interface. Our experiments provide a fresh insight into the tunneling measurements of complex heterostructures with buried interfaces.
Serum changes in pyridinoline, type II collagen cleavage neoepitope and osteocalcin in early stage male brucellosis patients
Authors: Li Qiang , Hu Lansheng , Zhao Zhijun , Ma Li , Li Jiquan , Xu Liqing , Wang Jiming 
Published: October 2020

AbstractMusculoskeletal changes are the most common clinical manifestation of brucellosis. The main objective of this study was to provide a better understanding of this disease, while also attempting to identify potential markers that can identify the early stage musculoskeletal changes associated with human brucellosis. In this case–control study, 41 male early-stage brucellosis patients (within 6 months of diagnosis) who had not received drug therapy and 44 matched controls were examined. Venous blood samples were collected and serum pyridinoline (PYD), type II collagen cleavage neoepitope (C2C) and osteocalcin (OC) levels were quantified using an enzyme-linked immunosorbent assay (ELISA). In the brucellosis group, the median serum levels of PYD (278.53 µg/L), C2C (82.23 µg/L) and OC (8.41 µg/L) were significantly elevated relative to the control group (Z = 5.686, 3.997, 3.579;P = 0.000). Serum PYD, C2C, and OC levels were increased in early-stage male brucellosis patients, and these factors appear to have promise as potential indicator biomarkers that can reflect the osteoarticular changes that occur in the early stage of human brucellosis.
Differential rotation in cholesteric pillars under a temperature gradient
Authors: Yoshioka Jun , Araoka Fumito 
Published: October 2020

AbstractSteady rotation is induced in cholesteric droplets dispersed in a specific liquid solvent under a temperature gradient. In this phenomenon, two rotational modes have been considered: (1) collective rotation of the local director field and (2) rigid-body rotation of the whole droplet structure. However, here we present another rotational mode induced in a pillar-shaped cholesteric droplet confined between substrates under a temperature gradient, that is, a differential rotation where the angular velocity varies as a function of the radial coordinate in the pillar. A detailed flow field analysis revealed that every pillar under a temperature gradient involves a double convection roll. These results suggested that the differential rotation in the cholesteric pillars was driven by the inhomogeneous material flow induced by a temperature gradient. The present experimental study indicates that the coupling between the flow and the director motion plays a key role in the rotation of the cholesteric droplets under the temperature gradient.
Elevated perfusate [Na+] increases contractile dysfunction during ischemia and reperfusion
Authors: King D. Ryan , Padget Rachel L. , Perry Justin , Hoeker Gregory , Smyth James W. , Brown David A. , Poelzing Steven 
Published: October 2020

AbstractRecent studies revealed that relatively small changes in perfusate sodium ([Na+]o) composition significantly affect cardiac electrical conduction and stability in contraction arrested ex vivo Langendorff heart preparations before and during simulated ischemia. Additionally, [Na+]o modulates cardiomyocyte contractility via a sodium-calcium exchanger (NCX) mediated pathway. It remains unknown, however, whether modest changes to [Na+]o that promote electrophysiologic stability similarly improve mechanical function during baseline and ischemia–reperfusion conditions. The purpose of this study was to quantify cardiac mechanical function during ischemia–reperfusion with perfusates containing 145 or 155 mM Na+ in Langendorff perfused isolated rat heart preparations. Relative to 145 mM Na+, perfusion with 155 mM [Na+]o decreased the amplitude of left-ventricular developed pressure (LVDP) at baseline and accelerated the onset of ischemic contracture. Inhibiting NCX with SEA0400 abolished LVDP depression caused by increasing [Na+]o at baseline and reduced the time to peak ischemic contracture. Ischemia–reperfusion decreased LVDP in all hearts with return of intrinsic activity, and reperfusion with 155 mM [Na+]o further depressed mechanical function. In summary, elevating [Na+]o by as little as 10 mM can significantly modulate mechanical function under baseline conditions, as well as during ischemia and reperfusion. Importantly, clinical use of Normal Saline, which contains 155 mM [Na+]o, with cardiac ischemia may require further investigation.
Improving maximal safe brain tumor resection with photoacoustic remote sensing microscopy
Authors: Ecclestone Benjamin R. , Bell Kevan , Abbasi Saad , Dinakaran Deepak , van Landeghem Frank K. H. , Mackey John R. , Fieguth Paul , Haji Reza Parsin 
Published: October 2020

AbstractMalignant brain tumors are among the deadliest neoplasms with the lowest survival rates of any cancer type. In considering surgical tumor resection, suboptimal extent of resection is linked to poor clinical outcomes and lower overall survival rates. Currently available tools for intraoperative histopathological assessment require an average of 20 min processing and are of limited diagnostic quality for guiding surgeries. Consequently, there is an unaddressed need for a rapid imaging technique to guide maximal resection of brain tumors. Working towards this goal, presented here is an all optical non-contact label-free reflection mode photoacoustic remote sensing (PARS) microscope. By using a tunable excitation laser, PARS takes advantage of the endogenous optical absorption peaks of DNA and cytoplasm to achieve virtual contrast analogous to standard hematoxylin and eosin (H&E) staining. In conjunction, a fast 266 nm excitation is used to generate large grossing scans and rapidly assess small fields in real-time with hematoxylin-like contrast. Images obtained using this technique show comparable quality and contrast to the current standard for histopathological assessment of brain tissues. Using the proposed method, rapid, high-throughput, histological-like imaging was achieved in unstained brain tissues, indicating PARS’ utility for intraoperative guidance to improve extent of surgical resection.
Impaired left amygdala resting state functional connectivity in subthreshold depression individuals
Authors: Peng Xiaoling , Lau Way K. W. , Wang Chanyu , Ning Lingfang , Zhang Ruibin 
Published: October 2020

AbstractSubthreshold depression (StD) affects people who experience clinically relevant depressive symptoms, which does not meet the diagnostic criteria for major depressive disorder (MDD). StD represents an ideal model for understanding the pathophysiological mechanisms of depression. Impaired emotion processing is a core feature of depression; careful investigation is required to better understand the neural correlates of emotion processing in depressed populations. In the current study, we explored whether the resting-state functional connectivity of the amygdala, a hub that taps a wide range of brain areas involved in emotion processing, is altered in individuals with StD when compared with healthy controls. Resting-state imaging data was collected from 59 individuals with StD and 59 age- and gender-matched controls. We found that the resting-state functional connectivity of the left amygdala with the cognitive control network and the left insula was significantly lower in people with StD than that in healthy controls. Such association was not observed in the right amygdala. Furthermore, functional connectivity strength between the left amygdala and the left precuneus was positively associated with depressive symptoms in individuals with StD. Our findings are in line with those reported in subjects with MDD, which may assist in further elucidating the pathophysiological mechanisms of depression, and contribute to the development of tailored treatments for individuals with StD who are at high risk of developing MDD.
Computer-generated moiré profilometry based on fringe-superposition
Authors: Li Chengmeng , Cao Yiping , Wang Lu , Wan Yingying , Li Hongmei , Xu Cai , Zhang Hechen 
Published: October 2020

AbstractA computer-generated moiré profilometry based on algebraic addition instead of algebraic multiplication is proposed. Firstly, the two AC components of the captured fringe patterns on the reference plane with $$\pi /2$$

π
/
2

phase difference are retrieved and saved in advance. While measuring, two sinusoidal gratings with $$\pi$$
π
phase difference are projected onto the measured object alternatively, and the corresponding deformed patterns are captured. Then the AC component of the captured deformed pattern can be separated exactly. When the positive and negative AC component of the captured deformed pattern are added to the two prestored AC components respectively, two moiré fringes only reflect sine and cosine of the object’s phase information can be successfully generated via a series of data processing procedures. Finally, the phase distribution of the measured object can be extracted by arctangent of the ratio of these two moiré fringes. Compared with computer-generated moiré profilometry based on algebraic multiplication, this proposed method can reduce the effect of high frequency noise and residual DC component on measurement and improve the measurement accuracy. While compared with $$\pi$$
π
phase shifting FTP, this method can measure more complex objects with better measurement capability. Experimental results verify the feasibility and validity of the proposed method.
Unique dynamic mode between Artepillin C and human serum albumin implies the characteristics of Brazilian green propolis representative bioactive component
Authors: Wu Fan , Song Xin-Mi , Qiu Yi-Lei , Zheng Huo-Qing , Hu Fu-Liang , Li Hong-Liang 
Published: October 2020

AbstractAs a representative bioactive component in Brazil green propolis, Artepillin C (ArtC; 3, 5-diprenyl-4-hydroxycinnamic acid) has been reported a wide variety of physiological activities including anti-tumor, anti-inflammatory, and antimicrobial activity etc. However, it seems incompatible that ArtC in vivo was characterized as low absorption efficiency and low bioavailability. In order to obtain the elucidation, we further investigated the physicochemical basis of ArtC interacting with human serum albumin (HSA) in vitro. We found a unique dynamic mode interaction between ArtC and HSA, which is completely different from other reported propolis bioactive components. Thermodynamic analysis showed that hydrophobic interactions and electrostatic forces are the main driving force. The competitive assay indicates that the binding site of ArtC with HSA is close to the Sudlow’s site I. The findings of this study reveal the unique physicochemical transport mechanism of ArtC in the human body, which helps to further understand the uniqueness of the representative functional components of Brazilian green propolis in the human body.
High sensitive label-free optical sensor based on Goos–Hänchen effect by the single chirped laser pulse
Authors: Benam Elnaz Rezaei , Sahrai Mostafa , Bonab Jafar Poursamad 
Published: October 2020

AbstractWe consider a four-level molecular system with two ground-state vibrational levels and two excited-state vibrational levels inside a constant cavity configuration. We discuss the reflected and transmitted Goos–Hänchen (GH) shifts of a positive and negative single-chirped laser pulse. The impacts of the laser field detuning, intensity of applied laser field, and appropriately tuning the chirp rate on GH shifts are then analyzed. It is also found that this sensor is very sensitive to the refractive index of the intracavity medium, which can coherently be controlled by the medium parameters. The results show that such a sensor can be most effective for detecting biological molecules with low concentration than the large number density, where a bit variation in the concentration of sample will lead to a great variation on the GH shifts.
Multi-variant differential evolution algorithm for feature selection
Authors: Hassan Somaia , Hemeida Ashraf M. , Alkhalaf Salem , Mohamed Al-Attar , Senjyu Tomonobu 
Published: October 2020

AbstractThis work introduces a new population-based stochastic search technique, named multi-variant differential evolution (MVDE) algorithm for solving fifteen well-known real world problems from UCI repository and compared to four popular optimization methods. The MVDE proposes a new self-adaptive scaling factor based on cosine and logistic distributions as an almost factor-free optimization technique. For more updated chances, this factor is binary-mapped by incorporating an adaptive crossover operator. During the evolution, both greedy and less-greedy variants are managed by adjusting and incorporating the binary scaling factor and elite identification mechanism into a new multi-mutation crossover process through a number of sequentially evolutionary phases. Feature selection decreases the number of features by eliminating irrelevant or misleading, noisy and redundant data which can accelerate the process of classification. In this paper, a new feature selection algorithm based on the MVDE method and artificial neural network is presented which enabled MVDE to get a combination features’ set, accelerate the accuracy of the classification, and optimize both the structure and weights of Artificial Neural Network (ANN) simultaneously. The experimental results show the encouraging behavior of the proposed algorithm in terms of the classification accuracies and optimal number of feature selection.
Active site competition is the mechanism for the inhibition of lipoprotein-associated phospholipase A2 by detergent micelles or lipoproteins and for the efficacy reduction of darapladib
Authors: Zhuo Shaoqiu , Yuan Chong 
Published: October 2020

AbstractLipoprotein associated phospholipase A2 (Lp-PLA2) has been characterized for its interfacial activation as well as inhibition by detergent micelles and lipoprotein particles. The enzyme has been shown to bind on the surfaces of hydrophobic aggregates, such as detergent micelles, lipoprotein particles and even polystyrene latex nanobeads. Binding to hydrophobic aggregates stimulates the activity of Lp-PLA2 but may not be the necessary step for catalysis. However, at higher concentrations, detergent micelles, latex nanobeads or lipoprotein particles inhibit Lp-PLA2 possibly by blocking the access of substrates to the active site. The competition mechanism also blocks inhibitors such as darapladib binding to Lp-PLA2 and reduces the efficacy of the drug. Darapladib has very low solubility and mainly exists in solutions as complexes with detergents or lipoprotein particles. The inhibition of Lp-PLA2 by darapladib is dependent on many factors such as concentrations of detergents or lipoproteins, incubation time, as well as the order of mixing reaction components. The in vitro Lp-PLA2 activity assays used in clinical studies may not accurately reflect the residual Lp-PLA2 activity in vivo. Darapladib has been found mainly bound on HDL and albumin when it is incubated with human serum. However, Lp-PLA2 is more sensitive to darapladib when bound on LDL and relatively resistant to darapladib when bound on HDL. Therefore, high cholesterol levels may decrease the efficacy of darapladip and cause the drug to be less effective in high risk patients. Our study will help to design better inhibitors for Lp-PLA2. The discoveries also contribute to understanding the mechanism of interfacial activation and inhibition for Lp-PLA2 and provide a new concept for researchers in building better kinetic model for interfacial enzymes.
Pan-cancer driver copy number alterations identified by joint expression/CNA data analysis
Authors: Wang Gaojianyong , Anastassiou Dimitris 
Published: October 2020

AbstractAnalysis of large gene expression datasets from biopsies of cancer patients can identify co-expression signatures representing particular biomolecular events in cancer. Some of these signatures involve genomically co-localized genes resulting from the presence of copy number alterations (CNAs), for which analysis of the expression of the underlying genes provides valuable information about their combined role as oncogenes or tumor suppressor genes. Here we focus on the discovery and interpretation of such signatures that are present in multiple cancer types due to driver amplifications and deletions in particular regions of the genome after doing a comprehensive analysis combining both gene expression and CNA data from The Cancer Genome Atlas.
Comparison of acid exfoliators in carbon nanosheets synthesis from stinging nettle (Urtica dioica) for electrochemical applications
Authors: Nuilek Kanokon , Wongwiriyapan Winadda , Sattayarut Vichuda , Simon Andrea , Koncz-Horváth Daniel , Ferenczi Tibor , Kristály Ferenc , Baumli Peter 
Published: October 2020

AbstractCarbon nanosheets (CNs) were successfully synthesized from nettle stem (NS) which is an inexpensive material with a high carbon content that is abundantly available in nature. CNs were produced using chemical (potassium hydroxide activation and acid exfoliation) and thermal treatments. Sulfuric (H2SO4), phosphoric (H3PO4) and nitric (HNO3) acid solutions were used for exfoliation. CNs exfoliated by H3PO4 have higher specific surface area (789 m2 g−1) compared to CNs exfoliated by H2SO4 (705 m2 g−1) and HNO3 (106 m2 g−1). In this work, NSCNs were found to be a potential candidate for electrode material in electrochemical capacitors. The maximum specific capacitance of the NSCNs exfoliated by H3PO4 is found to be 27.3 F g−1 at a current density of 0.05 A g−1, while the specific capacitance of NSCNs exfoliated by H2SO4 and HNO3 is 9.34 F g−1 and 1.71 F g−1, respectively. Energy density (0.06–0.95 Wh kg−1) and power density (20.9–26.7 W kg−1) of NSCNs are confirmed to be supercapacitor materials and can be applied in energy storage devices.
X-ray nanotomography of dry colloidal packings
Authors: Kim Yeseul , Lee Sangsul , Lim Jun , Weon Byung Mook 
Published: October 2020

AbstractRandom packings are crucial in understanding arrangement and geometry of particles. Random packings of dry small particles may be subject to adhesion or friction, as expected theoretically and numerically. We explore experimentally random packings of dry colloids with X-ray nanotomography that directly provides three-dimensional structural and geometric information of dry colloidal packings. We find that dry colloidal packings, as characterized by contact number and packing density, are quite consistent with adhesive loose packings that significantly deviate from random loose packings for hard spheres. This study may offer direct evidence for adhesive loose packings comprising dry small particles, as proven by X-ray nanotomography.