bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autobiographical memory as a latent vulnerability mechanism following childhood maltreatment: Association with future depression symptoms and prosocial behavior
Authors: Puetz Vanessa B. , Viding Essi , Hoffmann Ferdinand , Gerin Mattia I. , Sharp Molly , Rankin Georgia , Maguire Eleanor A. , Mechelli Andrea , McCrory Eamon J. 
Published: June 2020

AbstractObjectivesChildhood maltreatment is associated with altered neural reactivity during autobiographical memory (ABM) recall and a pattern of overgeneral memory (OGM). Altered ABM and OGM have been linked with psychopathology and poorer social functioning. The present study investigated the association between altered ABM and subsequent socio-emotional functioning (measured two years later) in a sample of adolescents with (N = 20; maltreatment group, MT) and without (N = 17; non-MT group) documented childhood maltreatment histories.MethodAt baseline, adolescents (aged 12.6 ± 1.45 years) were administered the Autobiographical Memory Test to measure OGM. Participants also recalled specific ABMs in response to emotionally valenced cue words during functional MRI. Adolescents in both groups underwent assessments measuring depressive symptoms and prosocial behavior at both timepoints. Regression analyses were carried out to predict outcome measures at follow-up controlling for baseline levels.ResultsIn the MT group, greater OGM at baseline significantly predicted reduced prosocial behavior at follow-up and showed a trend level association with elevated depressive symptoms. Patterns of altered ABM-related brain activity did not significantly predict future psycho-social functioning.ConclusionsThe current findings highlight the potential value of OGM as a cognitive mechanism that could be targeted to reduce risk of depression in adolescents with prior histories of maltreatment.
Inversion of Longer‐Period OBS Waveforms for P Structures in the Oceanic Lithosphere and Asthenosphere
Authors: Takeuchi Nozomu , Kawakatsu Hitoshi , Shiobara Hajime , Isse Takehi , Sugioka Hiroko , Ito Aki , Utada Hisashi 
Published: June 2020

AbstractWe performed waveform inversion of the P waveforms recorded by our BroadBand Ocean Bottom Seismometers (BBOBSs) deployed in the Northwestern Pacific. Consequently, the depth profile of the P velocity of the oceanic upper mantle, which has not been well resolved by previous surface wave or receiver function analyses, was revealed. We considered the azimuthal anisotropy in the lithosphere, which significantly improved the variance reduction from 34% to 44%. The resulting P model exhibited higher and lower velocities in the lithosphere and asthenosphere, respectively. The velocity contrast was found to be second/third of that observed in the previous S models; however the obtained model appeared to have some trade‐off with the VS structures in the vicinity of the source. We compared our P model with the previous S model obtained using our BBOBSs and obtained the VP/VS model. The resulting VP/VS model has two notable features. First, the lithosphere is characterized by a rapid increase in the VP/VS values with depth, which implies chemical stratification. Second, the VP/VS values in the vicinity of the lithosphere‐asthenosphere boundary (LAB) are larger than the synthetic values of any major upper mantle mineral predicted by considering the anharmonic effects, which suggests the effects of anelasticity or melt.
Demonstrating a High‐Resolution Gulf of Alaska Ocean Circulation Model Forced Across the Coastal Interface by High‐Resolution Terrestrial Hydrological Models
Authors: Danielson Seth L. , Hill David F. , Hedstrom Katherine S. , Beamer Jordan , Curchitser Enrique 
Published: June 2020

AbstractWe demonstrate a linking of moderately high resolution (1 km) terrestrial hydrological models to a 3‐D ocean circulation model having similar resolution in the northern Gulf of Alaska, where a distributed line source of freshwater runoff exerts strong influence over the shelf's hydrographic structure and flow dynamics. The model interfacing is accomplished via mass flux boundary conditions through the ocean model coastal wall at all land‐ocean adjoining grid cells. Despite the high runoff volume and lack of a coastal mixing estuary, the implementation maintains numerical stability by prescribing depth invariant and surface‐intensified inflows at fast and slow discharge grid cells, respectively. Based on comparisons against in situ hydrographic data, the coastal sidewall mass flux boundary condition results in more realistic hindcast surface salinity and salinity gradient fields than models that distribute coastal runoff in the form of spatially distributed precipitation. Correlations with observed thermal and haline monthly anomalies reveal statistically significant hindcast temporal variability during the freshet season when the signal‐to‐noise ratio is large. Comparisons of ocean models forced by high‐ and low‐resolution hydrological models reveal differences in salinity, surface elevation, and velocity fields, highlighting the value and importance of accurate coastal runoff fields. The model results improve our understanding of the regional influence of runoff on sea level elevations and the distribution and fate of fresh water. Our approach has potential applications to biogeochemical modeling in regions where distributed line source freshwater coastal discharges deliver heat, momentum, and chemical constituents that may influence the marine carbon pump.
Changing Mantle Sources and the Effects of Crustal Passage on the Steens Basalt, SE Oregon: Chemical and Isotopic Constraints
Authors: Moore N. E. , Grunder A. L. , Bohrson W. A. , Carlson R. W. , Bindeman I. N. 
Published: June 2020

AbstractContinental flood basalts are more prone to compositional modification from passage through thicker and (or) more felsic crust in comparison to their oceanic counterparts. The Steens Basalt in southeast Oregon (~17 Ma) is among the oldest and most mafic members of the Columbia River Basalt Group and provides a record of the early stages of flood basalt volcanism. We evaluate the balance of mantle sources in time during the onset of Columbia River Basalt Group magmatism and assess the effect of crustal passage using stratigraphically controlled Sr, Nd, Pb, Hf, Os, and O isotopic compositions, as well as whole rock major and trace element data.Mixing models indicate that depleted and enriched mantle sources identified by previous workers contribute in varying proportions during the life of the magmatic system, with the greatest contribution by depleted mantle when eruption rate and presumed intrusion rate increase. During waxing, enrichment of δ18O in some flows signals cryptic deep fractionation of abundant clinopyroxene followed by shallow fractionation of olivine ± clinopyroxene ± plagioclase. Os concentrations are among the highest worldwide at a given MgO (0.29–0.86 ppb at 6.0 to 10.9 wt.%). We argue that high Os results from scavenging of sulfides by recharging magmas passing through earlier crystallized magmas. Elevated 87Sr/86Sr in the latest stage supports modest assimilation of partial melts from mafic accreted terranes, facilitated by thermal priming of crust by persistent magmatism. This work provides a more detailed schematic view of the Steens Basalt magmatic system, from mantle origin through crustal staging.
Insulin receptor endocytosis in the pathophysiology of insulin resistance
Authors: Hall Catherine , Yu Hongtao , Choi Eunhee 
Published: June 2020

AbstractInsulin signaling controls cell growth and metabolic homeostasis. Dysregulation of this pathway causes metabolic diseases such as diabetes. Insulin signaling pathways have been extensively studied. Upon insulin binding, the insulin receptor (IR) triggers downstream signaling cascades. The active IR is then internalized by clathrin-mediated endocytosis. Despite decades of studies, the mechanism and regulation of clathrin-mediated endocytosis of IR remain incompletely understood. Recent studies have revealed feedback regulation of IR endocytosis through Src homology phosphatase 2 (SHP2) and the mitogen-activated protein kinase (MAPK) pathway. Here we review the molecular mechanism of IR endocytosis and its impact on the pathophysiology of insulin resistance, and discuss the potential of SHP2 as a therapeutic target for type 2 diabetes.
Number mismatch between cations and anions as an indicator for low lattice thermal conductivity in chalcogenides
Authors: Deng Tingting , Wei Tian-Ran , Huang Hui , Song Qingfeng , Zhao Kunpeng , Qiu Pengfei , Yang Jiong , Chen Lidong , Shi Xun 
Published: June 2020

AbstractThermal conductivity is one of the most fundamental properties of materials with the value being determined by nearly all-scale structural features and multiple physical processes. Rapidly judging material’s thermal conductivity is extremely important but challenging for the applications. The material genome paradigm offers a revolutionary way to efficiently screen and discover materials with designed properties by using accessible indicators. But such a performance indicator for thermal conductivity is quite difficult to propose due to the existence of multiple mechanisms and processes, especially for the materials with complex structures such as chalcogenides. In this study, the number mismatch between cations and anions is proposed as a practical performance indicator for lattice thermal conductivity in complex copper and silver chalcogenides, which can be used to explain the observed experimental data and find new low thermal conductivity materials. Such a number mismatch brings about rich phenomena to affect thermal conductivity including the complication of the unit cell and the creation of chemical hierarchy, point defects, rattling modes and lone-pair electrons. It is expected that this rich-connotation performance indicator can be also extended to other complex materials to discover designed thermal conductivities.
Genome-wide DNA methylation analysis of KRAS mutant cell lines
Authors: Tew Ben Yi , Durand Joel K. , Bryant Kirsten L. , Hayes Tikvah K. , Peng Sen , Tran Nhan L. , Gooden Gerald C. , Buckley David N. , Der Channing J. , Baldwin Albert S. , Salhia Bodour 
Published: June 2020

AbstractOncogenic RAS mutations are associated with DNA methylation changes that alter gene expression to drive cancer. Recent studies suggest that DNA methylation changes may be stochastic in nature, while other groups propose distinct signaling pathways responsible for aberrant methylation. Better understanding of DNA methylation events associated with oncogenic KRAS expression could enhance therapeutic approaches. Here we analyzed the basal CpG methylation of 11 KRAS-mutant and dependent pancreatic cancer cell lines and observed strikingly similar methylation patterns. KRAS knockdown resulted in unique methylation changes with limited overlap between each cell line. In KRAS-mutant Pa16C pancreatic cancer cells, while KRAS knockdown resulted in over 8,000 differentially methylated (DM) CpGs, treatment with the ERK1/2-selective inhibitor SCH772984 showed less than 40 DM CpGs, suggesting that ERK is not a broadly active driver of KRAS-associated DNA methylation. KRAS G12V overexpression in an isogenic lung model reveals >50,600 DM CpGs compared to non-transformed controls. In lung and pancreatic cells, gene ontology analyses of DM promoters show an enrichment for genes involved in differentiation and development. Taken all together, KRAS-mediated DNA methylation are stochastic and independent of canonical downstream effector signaling. These epigenetically altered genes associated with KRAS expression could represent potential therapeutic targets in KRAS-driven cancer.
Is Pyroglutamic Acid a Prognostic Factor Among Patients with Suspected Infection? A Prospective Cohort Study
Authors: Gueta Itai , Perach Ovadia Yarden , Markovits Noa , Schacham Yehoshua N , Epsztein Avi , Loebstein Ronen 
Published: June 2020

AbstractPyroglutamic acid (PGA) is a compound that accumulates during oxidative stress and hence, elevated levels may be associated with poor prognosis in patients with infection or sepsis. To examine this hypothesis, patients presenting with acute infection were recruited in the emergency department and prospectively followed for 30 days. Sport urine samples were quantified for PGA. Outcomes were mortality and composite outcome of death or organ failure. Thirty two (32%) patients had qSOFA≥2. Median urine PGA was 22.9 (IQR 17.64, 33.53) µmol/mmol creatinine. Four patients demonstrated PGA values ≥ 63 µmol/mmol creatinine. Univariate analysis showed that PGA concentration ≥ 75th percentile (i.e. 33.53 µmol/mmol creatinine) was associated with higher rates of in-hospital mortality (p = 0.041) with similar trend for PGA ≥ 63 µmol/mmol creatinine (p = 0.04). However, multivariate analysis showed that PGA was not associated with worse outcomes, whereas heart rate was associated with both composite outcomes (HR 1.0, p = 0.008 and HR 1.02, p = 0.001 for composite outcome with 30 days and in-hospital mortality, respectively). Among low risk patients, high PGA levels were consistently associated with worse outcomes. In conclusion, urine PGA concentration was not associated with worse outcomes among septic patients. Nevertheless, future studies should evaluate this association in larger cohorts.
Expression profile and bioinformatics analysis of circular RNAs in acute ischemic stroke in a South Chinese Han population
Authors: Li Shenghua , Chen Lan , Xu Chen , Qu Xiang , Qin Zhenxiu , Gao Jinggui , Li Jinpin , Liu Jingli 
Published: June 2020

AbstractRecent studies have found that circular RNAs (circRNAs) play crucial roles not only in the normal growth and the development of different tissues and organs but also in the pathogenesis and progression of various disorders. However, the expression patterns and the function of circRNAs in acute ischemic stroke (AIS) in the South Chinese Han population are unclear. In the present study, RNA sequencing (RNA-seq) data was generated from 3 AIS patients and 3 healthy controls. The circRNAs were detected and identified by CIRI2 and Find_circ software. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) analyses were used to detect the expression of circRNAs. Meanwhile, the potential diagnostic value of the selected circRNAs for AIS was assessed by generating receiver operating characteristic (ROC) curve with area under curve (AUC). The bioinformatic analysis of the host genes of differentially expressed (DE) circRNAs was performed by gene ontology (GO) enrichment, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, KOBAS for pathway analysis and regulatory network analysis. miRNA-circRNA and miRNA-mRNA interactions were predicted by using TargetScan, miRanda and starBase. CircRNA-miRNA-mRNA interaction networks were created with Cytoscape. Our result showed that there were 2270 DE circRNAs between AIS patients and healthy controls. Among them, 659 were found upregulated and 1611 were downregulated. Bioinformatic analysis showed that the DE circRNAs were related to the following biological processes: endocytosis, energy metabolism, apoptosis, FoxO signaling pathway, platelet activation, neurotrophin signaling pathway and VEGF signaling pathway, which may be associated with the pathological of AIS. Three randomly selected circRNAs were successfully validated by qRT‐PCR. The results show that hsa_circ_0005548 was significantly upregulated, while hsa_circ_0000607 and hsa_circ_0002465 were significantly downregulated in AIS. Furthermore, the AUC values for hsa_circ_005548, hsa_circ_0000607 and hsa_circ_0002465 were 0.51, 0.75 and 0.69, respectively, suggesting that hsa_circ_0000607 and hsa_circ_0002465 could be potential biomarkers for AIS. In addition, Bcl2 was predicted to be a direct target of miR-337-3p, and hsa_circRNA_0000607 was predicted to act as a sponge for miR-337-3p. Thus, hsa_circ_0000607 may be involved in AIS by regulating the miR-337-3p/Bcl2 axis. Collectively, our findings indicate that numerous dysregulated circRNAs may play pivotal functional roles in AIS and hsa_circ_0000607 may play a crucial role in the pathogenesis and progression of AIS by regulating the miR-337-3p/Bcl2 axis.
Triggering of eruptions at Axial Seamount, Juan de Fuca Ridge
Authors: Cabaniss Haley E. , Gregg Patricia M. , Nooner Scott L. , Chadwick William W. 
Published: June 2020

AbstractThe submarine volcano Axial Seamount has exhibited an inflation predictable eruption cycle, which allowed for the successful forecast of its 2015 eruption. However, the exact triggering mechanism of its eruptions remains ambiguous. The inflation predictable eruption pattern suggests a magma reservoir pressure threshold at which eruptions occur, and as such, an overpressure eruption triggering mechanism. However, recent models of volcano unrest suggest that eruptions are triggered when conditions of critical stress are achieved in the host rock surrounding a magma reservoir. We test hypotheses of eruption triggering using 3-dimensional finite element models which track stress evolution and mechanical failure in the host rock surrounding the Axial magma reservoir. In addition, we provide an assessment of model sensitivity to various temperature and non-temperature-dependent rheologies and external tectonic stresses. In this way, we assess the contribution of these conditions to volcanic deformation, crustal stress evolution, and eruption forecasts. We conclude that model rheology significantly impacts the predicted timing of through-going failure and eruption. Models consistently predict eruption at a reservoir pressure threshold of 12–14 MPa regardless of assumed model rheology, lending support to the interpretation that eruptions at Axial Seamount are triggered by reservoir overpressurization.
Positive-negative tunable liquid crystal lenses based on a microstructured transmission line
Authors: Algorri J. F. , Morawiak P. , Bennis N. , Zografopoulos D. C. , Urruchi V. , Rodríguez-Cobo L. , Jaroszewicz L. R. , Sánchez-Pena J. M. , López-Higuera J. M. 
Published: June 2020

AbstractIn this work, a novel technique to create positive-negative tunable liquid crystal lenses is proposed and experimentally demonstrated. This structure is based on two main elements, a transmission line acting as a voltage divider and concentric electrodes that distribute the voltage homogeneously across the active area. This proposal avoids all disadvantages of previous techniques, involving much simpler fabrication process (a single lithographic step) and voltage control (one or two sources). In addition, low voltage signals are required. Lenses with switchable positive and negative focal lengths and a simple, low voltage control are demonstrated. Moreover, by using this technique other optical devices could be engineered, e.g. axicons, Powell lenses, cylindrical lenses, Fresnel lenses, beam steerers, optical vortex generators, etc. For this reason, the proposed technique could open new venues of research in optical phase modulation based on liquid crystal materials.
From extraocular photoreception to pigment movement regulation: a new control mechanism of the lanternshark luminescence
Authors: Duchatelet Laurent , Sugihara Tomohiro , Delroisse Jérôme , Koyanagi Mitsumasa , Rezsohazy René , Terakita Akihisa , Mallefet Jérôme 
Published: June 2020

AbstractThe velvet belly lanternshark, Etmopterus spinax, uses counterillumination to disappear in the surrounding blue light of its marine environment. This shark displays hormonally controlled bioluminescence in which melatonin (MT) and prolactin (PRL) trigger light emission, while α-melanocyte-stimulating hormone (α-MSH) and adrenocorticotropic hormone (ACTH) play an inhibitory role. The extraocular encephalopsin (Es-Opn3) was also hypothesized to act as a luminescence regulator. The majority of these compounds (MT, α-MSH, ACTH, opsin) are members of the rapid physiological colour change that regulates the pigment motion within chromatophores in metazoans. Interestingly, the lanternshark photophore comprises a specific iris-like structure (ILS), partially composed of melanophore-like cells, serving as a photophore shutter. Here, we investigated the role of (i) Es-Opn3 and (ii) actors involved in both MT and α-MSH/ACTH pathways on the shark bioluminescence and ILS cell pigment motions. Our results reveal the implication of Es-Opn3, MT, inositol triphosphate (IP3), intracellular calcium, calcium-dependent calmodulin and dynein in the ILS cell pigment aggregation. Conversely, our results highlighted the implication of the α-MSH/ACTH pathway, involving kinesin, in the dispersion of the ILS cell pigment. The lanternshark luminescence then appears to be controlled by the balanced bidirectional motion of ILS cell pigments within the photophore. This suggests a functional link between photoreception and photoemission in the photogenic tissue of lanternsharks and gives precious insights into the bioluminescence control of these organisms.
The association of inflammasome and TLR2 gene polymorphisms with susceptibility to tuberculosis in the Han Taiwanese population
Authors: Liu Chi-Wei , Lin Chou-Jui , Hu Hui-Chun , Liu Hsiu-Jung , Chiu Yu-Chi , Lee Shih-Wei , Wu Lawrence Shih-Hsin 
Published: June 2020

AbstractPulmonary tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is a global public health concern. Although inflammasome and the toll-like receptor 2 (TLR2) genes play an important role in host defense against Mtb, the associations of polymorphisms in these genes with TB risk are incompletely understood. A total of 230 TB patients and 213 individuals without TB were enrolled in this study. A significant difference in the frequencies of different AIM2 rs2276405 genotypes between the non-TB and TB groups was detected. When the patients were stratified by gender or age, significant differences in genotype frequencies at NLRP3 rs34298354 in men and in non-aged (≤65-year-old) subjects and at IFI16 rs1772408 in women were found. OR analysis showed that the TC rs34298354 genotype in NLRP3 was associated with reduced risk of TB. In women, the AG rs1772408 genotype in IFI16 was associated with decreased TB risk. Haplotype analysis showed that, in comparison with the most common haplotype (T-T) of rs3804099-rs3804100 in the TLR2 gene, the C-T haplotype was associated with an increased risk for TB. Our study indicates that rs34298354 in NLRP3 and rs1772408 in IFI16 protect individuals from TB, and that the less common TLR2 haplotype is associated with increased TB susceptibility.
Multidisciplinary analysis of a 750 kW PMSM for marine propulsion including shock loading response
Authors: Prieto Borja , Satrústegui Marco , Elósegui Ibon , Gil‐Negrete Nere 
Published: June 2020

This study presents the electromagnetic, thermal and mechanical analysis of a 750 kW, 1200 rpm, 690 V surface permanent magnet motor aimed at marine propulsion (azimuth thruster). Based on a preliminary machine design, key electromagnetic design aspects including magnet demagnetisation and magnet loss reduction by tangential and axial segmentation are assessed. Then, three different cooling solutions are evaluated via computational fluid dynamics simulations combining the use of a water‐jacket surrounding the stator, wafters attached to the rotor structure and the addition of an inner fan. Subsequently, the dynamic design analysis method is applied in order to check the machine's response to shock loadings due to underwater explosions. Finally, a machine prototype is successfully manufactured and tested, showing the proper fulfilment of the design requirements.