bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of plasma pentraxin 3 concentration with angiographic and clinical outcomes in patients with acute ST‐segment elevation myocardial infarction treated by primary angioplasty
Authors: Dharma Surya , Sari Novi Y. , Santoso Anwar , Sukmawan Renan , Rao Sunil V. 
Published: November 2019

AbstractObjectiveTo evaluate the association of plasma long pentraxin 3 (PTX3) concentration with angiographic and clinical outcomes in patients with acute ST‐segment elevation myocardial infarction (STEMI) treated by primary angioplasty.BackgroundWhether concentration of PTX3, a sensitive marker of inflammation, associates with angiographic and clinical outcomes in STEMI patients treated by primary angioplasty is unknown.MethodsWe prospectively enrolled 335 consecutive patients with acute STEMI undergoing primary angioplasty. Blood samples for plasma PTX3 measurement were drawn in all patients at the emergency department before primary angioplasty, and were measured by ELISA method.ResultsThe median PTX3 concentrations were higher in patients with thrombus burden grade 4 and 5 versus grade <4 on initial coronary angiogram (0.29 ng/ml vs. 0.24 ng/ml, p = .02), thrombolysis in myocardial infarction (TIMI) grade <3 vs. TIMI grade‐3 flow after primary angioplasty (0.31 ng/ml vs. 0.24 ng/ml, p < .001), incomplete versus complete ST‐segment resolution within 12 hr after angioplasty (0.29 ng/ml vs. 0.22 ng/ml, p = .001) and in patients who did not survive versus those who survived at 30 days (0.44 ng/ml vs. 0.26 ng/ml, p = .001). A linear correlation was observed between PTX3 concentration and baseline leukocyte count (Spearman correlation = 0.21, p < .001). After adjustment for laboratory and selected clinical variables, patients in the highest quartile of PTX3 concentration (≥0.4 ng/ml) were associated with increased risk of 30‐day mortality (hazard ratio = 11.83; 95% confidence interval = 1.52–92.27, p = .01).ConclusionThis study suggests that higher plasma PTX3 concentration associates with worse angiographic and clinical outcomes in STEMI patients treated by primary angioplasty.
Enhanced Sensitivity to Local Dynamics in Peptides by Use of Temperature‐Jump IR Spectroscopy and Isotope Labeling
Authors: Scheerer David , Chi Heng , McElheny Dan , Keiderling Timothy A. , Hauser Karin 
Published: November 2019

AbstractSite‐specific isotopic labeling of molecules is a widely used approach in IR spectroscopy to resolve local contributions to vibrational modes. The induced frequency shift of the corresponding IR band depends on the substituted masses, as well as on hydrogen bonding and vibrational coupling. The impact of these different factors was analyzed with a designed three‐stranded β‐sheet peptide and by use of selected 13C isotope substitutions at multiple positions in the peptide backbone. Single‐strand labels give rise to isotopically shifted bands at different frequencies, depending on the specific sites; this demonstrates sensitivity to the local environment. Cross‐strand double‐ and triple‐labeled peptides exhibited two resolved bands that could be uniquely assigned to specific residues, the equilibrium IR spectra of which indicated only weak local‐mode coupling. Temperature‐jump IR laser spectroscopy was applied to monitor structural dynamics and revealed an impressive enhancement of the isotope sensitivity to both local positions and coupling between them, relative to that of equilibrium FTIR spectroscopy. Site‐specific relaxation rates were altered upon the introduction of additional cross‐strand isotopes. Likewise, the rates for the global β‐sheet dynamics were affected in a manner dependent on the distinct relaxation behavior of the labeled oscillator. This study reveals that isotope labels provide not only local structural probes, but rather sense the dynamic complexity of the molecular environment.
Do mutual fund networks affect corporate social responsibility? Evidence from China
Authors: Qi Lujun , Wang Lixiang , Li Wei'an 
Published: November 2019

AbstractThe mutual fund plays an important role in corporate governance and corporate social responsibility. From the perspective of the social network, using data from A‐listed companies in China from 2009 to 2016, this paper empirically tests the influence of mutual fund networks on corporate social responsibility behaviours. To solve the sample selection bias in this study, we utilize propensity score matching to find the different social responsibility behaviours between firms with or without highly concentrated mutual funds. Our results suggest that mutual fund investors positively impact a firm's corporate social responsibility performance, as predicted. The fund network centrality and pressure mechanism have a positive impact on corporate social responsibility performance because they provide more peer pressure and network information to firms in which they are heavily invested. This paper provides new evidence on how mutual fund investors affect corporate social responsibility performance, which is meaningful to examine in corporate green governance.
Synthesis, evaluation, molecular docking, and molecular dynamics studies of novel N‐(4‐[pyridin‐2‐yloxy]benzyl)arylamine derivatives as potential antitubercular agents
Authors: Verma Ruchi , Boshoff Helena I. M. , Arora Kriti , Bairy Indira , Tiwari Mradul , Varadaraj Bhat G. , Shenoy G. Gautham 
Published: November 2019

AbstractA new series of novel triclosan (2,4,4′‐trichloro‐2′‐hydroxydiphenylether) analogues were designed, synthesized, and screened for their in vitro antimycobacterial and antibacterial activities. Most of the compounds showed significant activity against Mycobacterium tuberculosis H37Rv strain with minimum inhibitory concentration (MIC) values in 20–40 μM range in GAST/Fe medium when compared with triclosan (43 μM) in the first week of assay, and after additional incubation, seven compounds, that is, 2a, 2c, 2g, 2h, 2i, 2j, and 2m, exhibited MIC values at the concentration of 20–40 μM. The compounds also showed more significant activity against Bacillus subtilis and Staphylococcus aureus. The synthesized compounds showed druggable properties, and the predicted ADME (absorption, distribution, metabolism, and excretion) properties were within the acceptable limits. The in silico studies predicted better interactions of compounds with target protein residues and a higher dock score in comparison with triclosan. Molecular dynamics simulation study of the most active compound 2i was performed in order to further explore the stability of the protein–ligand complex and the protein–ligand interaction in detail.
Distinct seasonal dynamics of responses to elevated CO2in two understorey grass species differing in shade‐tolerance
Authors: Holub Petr , Klem Karel , Linder Sune , Urban Otmar 
Published: November 2019

AbstractUnderstorey plant communities are crucial to maintain species diversity and ecosystem processes including nutrient cycling and regeneration of overstorey trees. Most studies exploring effects of elevated CO2concentration ([CO2]) in forests have, however, been done on overstorey trees, while understorey communities received only limited attention.The hypothesis that understorey grass species differ in shade‐tolerance and development dynamics, and temporally exploit different niches under elevated [CO2], was tested during the fourth year of [CO2] treatment. We assumed stimulated carbon gain by elevated [CO2] even at low light conditions in strongly shade‐tolerantLuzula sylvatica, while its stimulation under elevated [CO2] in less shade‐tolerantCalamagrostis arundinaceawas expected only in early spring when the tree canopy is not fully developed.We found evidence supporting this hypothesis. While elevated [CO2] stimulated photosynthesis inL. sylvaticamainly in the peak of the growing season (by 55%–57% in July and August), even at low light intensities (50 µmol m−2 s−1), stimulatory effect of [CO2] inC. arundinaceawas found mainly under high light intensities (200 µmol m−2 s−1) at the beginning of the growing season (increase by 171% in May) and gradually declined during the season. Elevated [CO2] also substantially stimulated leaf mass area and root‐to‐shoot ratio inL. sylvatica, while only insignificant increases were observed inC. arundinacea.Our physiological and morphological analyses indicate that understorey species, differing in shade‐tolerance, under elevated [CO2] exploit distinct niches in light environment given by the dynamics of the tree canopy.
Environmental DNA surveys help to identify winter hibernacula of a temperate freshwater turtle
Authors: Feng Wenxi , Bulté Grégory , Lougheed Stephen C. 
Published: November 2019

AbstractBackground and aimsOverwintering is a critical part of the annual cycle of animals living at high latitudes, and selection of overwintering sites (hibernacula) is important to population persistence. Identifying the overwintering sites of aquatic species is challenging in areas where water bodies are frozen for significant parts of the year. We tested whether environmental DNA (eDNA) approaches could help to locate them.Materials and methodsWe conducted environmental DNA surveys of underwater overwintering sites of the northern map turtle (Graptemys geographica), a species of conservation concern in Canada. We collected water samples under the ice in winter across a mid‐sized temperate lake and used quantitative PCR with a species‐specific probe to quantify concentrations of map turtle eDNA.Results and discussionWe found localized eDNA signals consistent with known overwintering sites and one previously suspected site. The latter was further confirmed using underwater remote operated vehicle (ROV) visual surveys.ConclusionsOur study confirms that eDNA can offer insights on a critical part of the annual cycle of aquatic species, for which we know very little.
Thermally Induced Spin Transition in a 2D Ferrous Nitroprusside
Authors: Avila Yosuan , Plasencia Yosdel , Osiry Hernandez , Martínez‐dlCruz Lorena , González Montiel Marlene , Reguera Edilso 
Published: November 2019

AbstractInvited for the cover of this issue is Edilso Reguera from Instituto Politécnico Nacional, Unidad Legaria, Ciudad México, Mexico. The cover image shows the magnetization curves and Mössbauer spectra for temperature‐induced spin crossover in a 2D ferrous nitroprusside.
Comparison of efficacy of diclofenac and tramadol in relieving pain in patients of acute pancreatitis: A randomized parallel group double blind active controlled pilot study
Authors: Kumar Nadipalli S. , Muktesh Gaurav , Samra Tanvir , Sarma Phulen , Samanta Jayanta , Sinha Saroj K. , Dhaka Narendra , Yadav Thakur D. , Gupta Vikas , Kochhar Rakesh 
Published: November 2019

AbstractBackgroundOpioids and non steroidal anti inflammatory drugs (NSAIDs) are commonly used for pain relief in acute pancreatitis (AP). Opioids carry risk of sphincter of oddi constriction. Although diclofenac prevents post endoscopic retrograde cholangio‐pancreatography (ERCP) pancreatitis, few reports of diclofenac associated AP are also present. Although, both tramadol and diclofenac are commonly used for pain relief in AP, no study has evaluated their comparative efficacy and safety.Materials and MethodsForty‐six eligible participants were randomized to either diclofenac or tramadol. Primary objectives of our study were improvement in pain intensity on visual analogue scale (VAS pain score after 1 hr of drug administration) and number of patients requiring supplementary analgesia. The secondary objectives were total number of times of supplementary analgesia requirement, time to significant decrease (33%) in VAS pain score from baseline, number of painful days (VAS pain score >5), VAS pain score on 7th day, side effects, all cause death and complications of pancreatitis between the two groups.ResultsAlthough 46 patients were randomized, the final analysis included 41 participants. Five patients were withdrawn from the study (intubation = 3, altered sensorium = 2). No significant difference was seen in terms of VAS score after 1 hr of drug administration, number of patients requiring supplementary analgesic and number of painful days. However, time taken to significant reduction of pain was lower in the diclofenac group (p = .028). Both the agents were comparable in terms of safety. Although complications were less in the diclofenac group, the difference was not statistically significant.ConclusionBoth diclofenac and tramadol are equally effective in controlling pain in AP with similar safety profile.SignificanceThere are no studies that have compared the safety and efficacy of two commonly used analgesics for pain relief in patients with AP. We found that both diclofenac and tramadol are equally effective in decreasing the pain associated with AP. There is also no significant difference in the incidence of side effects between both the groups. Hence both diclofenac and tramadol can be used safely and effectively for pain control in AP.Trial registration: The trial was registered with clinical trials registry India (Number‐ CTRI/2018/05/014309).
The role of professional groups in policy change: Physician's organizations and the issue of local medical provision shortages in France and Germany
Authors: Hassenteufel Patrick , Schweyer François‐Xavier , Gerlinger Thomas , Henkel Rüdiger , Lückenbach Caspar , Reiter Renate 
Published: November 2019

AbstractThis article proposes an endogenous perspective on policy change, combining the analysis of the policy process (policy framing, decision and implementation) with the analysis of the transformation of professional groups and their organizational representation. It deals with the case of territorial undersupply in primary care provision, which has become a key issue in healthcare policies in France and Germany since 2000 (the analysis goes up to 2018). Policy changes in these two health insurances systems cannot be explained only by the salience of the problem, framed as “medical deserts” in France and as “lack of physicians” in Germany. We propose an explanation based on the internal fragmentation of the medical profession, playing a paradoxical role: as limiters of change (for the established and institutionalized organizations) and as promoters of change (for the medical entrepreneurs shaping new organizations defining and supporting new primary care service structures).
Foreign exchange risk in stock returns
Authors: Rendón Jairo Andrés 
Published: November 2019

AbstractThis paper examines whether regional currency premiums explain foreign stock returns in a multifactor global asset pricing model for four different geographical regions. In the model, the regional currency premium is the spread between the return of a portfolio of currency investments from a given region and the average global currency return. The estimation is performed by adding the regional currency premium to a global four‐factor model that includes momentum and the Fama and French factors (market, size, and book‐to‐market factors). Tests of the model's ability to explain both the time series and the cross section of stock returns show that currency risk premium improves the fitness of global factors in explaining domestic returns, although models with domestic factors still outperform the model with global factors and currency risk. The results indicate that the regional currency premium factor captures dimensions of risks not captured by the Fama and French and momentum factors.
Do long‐term swap rate and stock price give an impact on Japanese Real Estate Investment Trust market under quantitative and qualitative easing and negative interest rate policy?
Authors: Ito Takayasu 
Published: November 2019

AbstractAn increase in stock price has a positive impact on the Real Estate Investment Trust (REIT) market, but an increase in interest rate has a negative impact on the REIT market in the regime of quantitative and qualitative easing (QQE). The wealth effect holds. As for the impact of interest rate, swap rate of 30 years is larger than that of 20 years in the period of QQE. On the other hand, all the negative coefficients of stock price are statistically significant at the 1% level in the period of negative interest rate policy (NIRP). But none of the negative coefficients of interest rate are significant even at the 10% level. This result is very rare in the analysis of REIT market not only in Japan, but also in other countries such as USA. Investors tend to buy REITs to compensate for the sluggish stock market and reduced gains in the fixed income market. When the Bank of Japan adopts QQE, normal function of REIT market is maintained. But after they introduce NIRP, normal function of REIT market is lost. This phenomenon is a negative effect of NIRP.
Evaluation of ionic liquid separation ability for the benzene–methanol mixture by extractive distillation
Authors: Li Wenxiu , Zhang Yu , Wang Lida , Feng Huisheng , Zhang Tao 
Published: November 2019

AbstractBACKGROUNDBenzene–methanol azeotrope can be formed at atmospheric pressure. Extractive distillation is widely used in the separation of azeotrope. The key factor for extractive distillation is the selection of entrainer. The minimal total annual cost of extractive distillation process can be used as objective function to evaluate the separation performance of ionic liquid entrainer. Intermolecular interaction energy can be used to analyze separation mechanisms.RESULTAn Aspen Plus software database belonging to the three ionic liquids 1‐hexyl‐3‐methylimidazolium acetate, 1‐octyl‐3‐methylimidazolium acetate and 1‐decyl‐3‐methylimidazolium acetate was established. The minimal total annual costs of three extractive distillation processes for the separation of benzene–methanol mixture with different ionic liquids were obtained by sequential iterative method. The feed rate of entrainer was also obtained under the optimized conditions. Among the three extractive distillation processes with different ionic liquid, the total annual cost and the entrainer feed rate of the extractive distillation process with 1‐hexyl‐3‐methylimidazolium acetate as entrainer are the smallest. The intermolecular interaction energies in the ternary system of benzene–methanol–ionic liquid were obtained using the Gaussian 09 software package based on the density functional theory. The separation mechanisms and the extractive distillation process of benzene–methanol azeotrope with ionic liquid as entrainer was interpreted by the intermolecular interaction energy.CONCLUSIONThe results show that the separation ability of 1‐hexyl‐3‐methylimidazolium acetate is higher than that of 1‐octyl‐3‐methylimidazolium acetate or 1‐decyl‐3‐methylimidazolium acetate. Intermolecular interaction energy analysis can be used in the screening and design of ionic liquid entrainer. © 2019 Society of Chemical Industry
A convenient green synthetic approach to the synthesis of novel bioactive selenolo[2,3‐c]pyrazoles as antibacterial and antifungal agents
Authors: Zaki Remon M. , El‐Ossaily Yasser A. , Geies Ahmed A. 
Published: November 2019

AbstractA series of new pyrimidine, triazine, and isoindole heterocycles fused to the selenolopyrazole ring system was synthesized by various condensation reactions of the amino selenolopyrazole carboxamide 1, which was performed by a new green methodology. The pyrimidinone compound 6 was used as a versatile precursor for several aromatic nucleophilic substitution reactions to produce the sulfanyl pyrimidines 10a‐c and the corresponding amines 11a‐c and 12a, b. Assignment of the chemical structures for the newly synthesized compounds was confirmed by elemental and spectral analyses including Fourier transform infrared (FTIR), 1H‐NMR, and 13C‐NMR and mass spectroscopy for some of them. Furthermore, some of these compounds were screened against various pathogenic bacterial and fungal strains. Their results demonstrated that some of them revealed remarkable antimicrobial activities.
Transfer‐learning‐based Raman spectra identification
Authors: Zhang Rui , Xie Huimin , Cai Shuning , Hu Yong , Liu Guo‐kun , Hong Wenjing , Tian Zhong‐qun 
Published: November 2019

AbstractDeep‐learning‐based spectral identification received intensive interests benefiting from the availability of large scale spectral databases. However, for the identification of spectroscopic data such as Raman, the massive experimental data remained challenging, impeding the application of deep neural networks. Here, we describe a new approach with a transfer‐learning model pretrained on a standard Raman spectral database for the identification of Raman spectra data of organic compounds that are not included in the database and with limited data. Our results show that, with transfer learning, classification accuracy improvement of our convolutional neural network reaches 4.1% and that of our fully connected deep neural network reaches 5.0%. By investigating the influence of the source datasets, we find that our transfer learning method is able to incorporate both relevant and seemingly irrelevant source datasets for pretraining, and the relevant source dataset brings better classification accuracy than that of the seemingly irrelevant source dataset. This study demonstrates that the transfer learning technique has great potential in the effective identification of Raman spectra when the number of Raman data is limited.
Synthesis of high added value compounds through catalytic oxidation of 2‐phenylethanol: A Kinetic study
Authors: Ben Hmida Rania , Frikha Nourzed , Bouguerra Neji Soumaya , Kit Geoffrey , Medina Francisco , Bouaziz Mohamed 
Published: November 2019

AbstractAn effective procedure was developed to produce high‐value added phenolic compounds through the conversion of 2‐phenylethanol (2‐PhEt) by using acid‐activated clays KSF for the hydrogen peroxide. Owing to KSF's ability to catalyze a variety of complex oxidations, it was likely to convert 2‐PhEt to hydroxytyrosol (HTY) and tyrosol (TY) derivatives. The analyses of catalytic solution revealed that the optimum conditions, giving a higher concentration of oxidation products such as HTY, were as follows: 2‐PhEt concentration 10−2 mol/L, the hydrogen peroxide concentration 5.05 × 10−2 and 0.6 g L–1 of KSF clays . The yield during the conversion reaction into HTY was around 25%. All compounds in the reaction mixture were identified by mass spectrophotometry using a LC‐MS apparatus. HTY, TY, meta‐tyrosol and ortho‐tyrosol were the major compounds. The antioxidant activity was realized by 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) method. In fact, it is revealed that the strongest inhibition percentage (PI = 96) was detected with the increase in the concentration of HTY. The approach proposed in the present work presents an environment friendly method.