bluuebunny/crossref_metadata_2025_split huggingface dataset:
A phase II trial of durvalumab (MEDI4736) and tremelimumab with chemotherapy in metastatic EGFR mutant non-squamous non-small cell lung cancer (NSCLC) following progression on EGFR tyrosine kinase inhibitors (TKIs) (ILLUMINATE).
Authors: Lee Chee Khoon , Subramaniam Shalini , Mersiades Antony , Mitchell Jenna , Jurkovic Hannora , Walker Mariya , Le Loc , Brown Chris , Solomon Benjamin J. , John Tom , Stockler Martin R. , Liao Bin-Chi , Yang James Chih-Hsin , Chiu Chao-Hua 
Published: May 2020

TPS9631 Background: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have proven remarkably effective in the treatment of advanced EGFR mutant non-small cell lung cancer (NSCLC). However, drug resistance is inevitable and outcomes with subsequent platinum-pemetrexed chemotherapy are poor. The role of immune-checkpoint inhibitor monotherapy in EGFR mutant NSCLC remains uncertain with trials demonstrating inferior survival outcomes compared to chemotherapy. However, a recent randomised study with combination checkpoint inhibitor-chemotherapy demonstrated improved survival over chemotherapy alone in this patient population. This study aims to evaluate the efficacy and tolerability of combination dual immune-checkpoint blockade, durvalumab and tremelimumab, with platinum-pemetrexed chemotherapy in metastatic EGFR mutant NSCLC following progression on EGFR-TKIs. Methods: This international phase II cohort study will recruit 100 participants from Australia and Taiwan with advanced EGFR mutant NSCLC following disease progression with EGFR-TKIs [Cohort 1 (n=50): T790M mutation negative on tissue and plasma; Cohort 2 (n=50): T790M mutation positive on tissue and/or plasma, and progression on3rd generation TKIs]. Participants will receive 4 cycles of induction durvalumab 1500mg and tremelimumab 75mg with platinum-pemetrexed chemotherapy every 3 weeks, followed by maintenance durvalumab 1500mg and pemetrexed 500mg/m2 every 4 weeks until disease progression. Response will be assessed at 6 and 12 weeks, then 8-weekly during the first year, and 12-weekly thereafter. Major endpoints include objective tumour response rate (OTRR; RECIST1.1; primary), disease control rate, OTRR (iRECIST), progression-free survival, overall survival, and adverse events. Correlative studies include biomarker assessment as potential predictive/prognostic factors. ILLUMINATE is a collaboration between the Australasian Lung Cancer Trials Group, National Health Research Institutes (Taiwan) and the NHMRC Clinical Trials Centre, University of Sydney. As of 6/2/2020, 11 of planned 100 participants have been recruited. Clinical trial information: NCT03994393 .
Randomized phase III study of first-line pembrolizumab plus pemetrexed/platinum followed by pembrolizumab and maintenance olaparib versus pemetrexed in patients with metastatic nonsquamous non-small cell lung cancer (NSCLC): KEYLYNK-006.
Authors: Gray Jhanelle Elaine , Owonikoko Taofeek Kunle , Kato Terufumi , Cardona Zorrilla Andres Felipe , Wagman Joanne , Chen Xinqun , Zhao Bin , Schulz Christian 
Published: May 2020

TPS9632 Background: First-line treatment with pembrolizumab + pemetrexed/platinum improved clinical outcomes in patients with advanced nonsquamous NSCLC in KEYNOTE-021 and KEYNOTE-189. Poly(ADP-ribose) polymerase inhibitors (PARPi), including olaparib, have been shown to upregulate PD-L1 expression in preclinical studies, and preliminary evidence suggests potential therapeutic benefit and acceptable safety with PARPi plus anti–PD-(L)1 therapy. KEYLYNK-006 (NCT03976323) evaluates first-line pembrolizumab + pemetrexed/platinum followed by pembrolizumab + olaparib vs pembrolizumab + pemetrexed in patients with metastatic nonsquamous NSCLC. Methods: This phase III, randomized, open-label trial enrolls patients aged ≥18 years with histologically/cytologically confirmed treatment-naive, metastatic, nonsquamous NSCLC. Patients (target n = 792) receive induction pembrolizumab 200 mg + pemetrexed 500 mg/m2 + carboplatin AUC 5 mg/mL/min or cisplatin 75 mg/m2 Q3W for 4 cycles. Patients with PR/CR or SD are randomized (target n = 618) 1:1 to pembrolizumab 200 mg Q3W (31 cycles) + maintenance olaparib 300 mg twice daily or pembrolizumab + pemetrexed 500 mg/m2 Q3W stratified by ECOG PS (0 vs 1), PD-L1 tumor proportion score (<50% vs ≥50%), and response (CR/PR vs SD). Tumor imaging per RECIST version 1.1 (≤5 per organ; maximum 10 total lesions) by central review (BICR) is performed at baseline and Q6W until 60 weeks after randomization, then Q9W until disease progression, start of new cancer therapy, study withdrawal, or death. Primary endpoints are PFS (RECIST 1.1 by BICR) and OS estimated by the Kaplan-Meier method, stratified log-rank test, and Cox proportional hazard model with Efron’s method of tie handling. Secondary endpoints are safety and quality of life; ORR and duration of response are exploratory endpoints. AEs are monitored throughout the study until 30 days after the last dose of treatment (90 days for serious AEs) and graded using NCI CTCAE, version 4.0. The study began enrolling in June 2019. Clinical trial information: NCT03976323 .
Biological effects of amniotic membrane on diabetic foot wounds: a systematic review
Authors: Paggiaro André Oliveira , Menezes Andriws Garcia , Ferrassi Alexandra Donizetti , De Carvalho Viviane Fernandes , Gemperli Rolf 
Published: May 2020

Objective: The amniotic membrane has biological properties that are beneficial to the wound healing process of diabetic foot ulcers (DFU). Our aim is to analyse the scientific evidence found in literature on the use of the amniotic membrane to stimulate DFU healing. Method: A systematic review of amniotic membrane's influence was undertaken, using the search terms ‘placenta’ ‘diabetic foot’ ‘amnion’ and biological dressing’, assessing the outcomes ‘wound healing’ and ‘wound healing time’, in DFU. Following the inclusion and exclusion criteria, randomised controlled trials (RCT) were identified, and the risk of bias was analysed according to the Cochrane risk of bias tool. We conducted a meta-analysis of the two outcomes to evaluate the level of evidence. Results: We identified six clinical trials, with a total of 331 patients. The most common risks of bias in the studies were selection, attrition, and detection biases. From the meta-analysis, the difference of the intervention group (amnion) in relation to the control group was statistically significant. We found that wound healing in the group treated with amniotic membrane occurs 2.32 times more often and is 32 days faster in comparison with the group that used conventional dressings. Conclusion: There is statistical evidence to support the effectiveness of amniotic membrane in comparison with other conventional dressings. In addition, there is a clear tendency for the use of amniotic membrane treatment to result in a larger number of DFUs healing at a quicker rate.
The role of nutrition in critical care
Authors: Latimer-Jones Kathryn 
Published: May 2020

Critically ill patients have conditions that are considered life-threatening and require comprehensive care and constant monitoring; nutritional support plays a key role in the recovery of these patients and is an area of veterinary medicine that is very easy for the registered veterinary nurse (RVN) to have an active role in. Critically ill patients are at increased risk of malnutrition; acute and chronic illness, trauma and inflammation induced stress-related catabolism, and drug-induced adverse effects may reduce appetite or increase nausea and vomiting. Challenges exist in the provision of support, especially in the anorexic patient. This article focuses on how severe physiological stress affects animals that are critically ill and how this might lead to malnutrition, how to accurately calculate energy requirements, and discusses the importance of selecting the most appropriate diet to improve patient outcomes.
PERSISTENCIA TEMPORAL DO ARMAZENAMENTO DE ÁGUA NO SOLO PARA DEFINIÇÃO DA REGIÃO DE MONITORAMENTO EM ÁREA IRRIGADA
Authors: Hara Anderson Takashi , Gonçalves Antônio Carlos Andrade , Santos Fernando André  Silva , Rezende Roberto , Domingues João Vitor da Silva 
Published: May 2020

A lâmina de água armazenada no solo, em uma área vegetada, apresenta variação espaço-temporal, o que estabelece incertezas em relação à região a ser monitorada para fins de controle de irrigação. Tendo-se como premissa o fato de que o seu padrão espacial de distribuição é persistente no tempo, pode-se identificar a região que sistematicamente apresenta valores médios representativos de toda a área, empregando as análises de estabilidade temporal. Mas esta persistência temporal em uma região sempre está associada a uma variabilidade em torno da média geral, o que levou à proposição de um indicador da consistência temporal (ICT). Para o desenvolvimento do trabalho, cultivou-se Urochloa decumbens em uma área experimental, solo de textura muito argilosa, durante dois ciclos anuais. Em cada ciclo, foram feitas medidas da lâmina de água armazenada no solo (ARM), durante ciclos de secamento do solo, e também do índice de área foliar (IAF) da cultura. O emprego de técnicas geoestatísticas, associadas à análise de estabilidade temporal foram realizadas. Os resultados evidenciam que é possível caracterizar o ICT como um indicador adequado e conveniente como suporte à tomada de decisão em questões referentes ao monitoramento de água no solo em sistemas agrícolas irrigados.
Construindo o Projeto Cuidadosamente: reflexão sobre a saúde mental dos graduandos de Enfermagem frente ao COVID-19
Authors: Rocha Natália Loureiro , Sora Alcilea Barbosa de Andrade , Lapa Alessandra da Terra , Dos Santos Daniele Durval 
Published: May 2020

O presente relato de experiência visa destacar a vivência dos autores na construção do Projeto Cuidadosamente em uma universidade privada localizada no município do Rio de Janeiro. Objetiva-se com esse estudo apontar a sua inserção prática, bem como, retratar a importância de um projeto desta magnitude no cuidado à saúde psíquica dos acadêmicos de enfermagem, principalmente no contexto atual de isolamento social pela pandemia de COVID-19. Conclui-se que a ação possibilita a construção de uma rede de apoio entre os próprios colegas de classe que estão experenciando as mesmas dificuldades com esse isolamento social e ameniza situações que possam maximizar ou desencadear algum tipo de transtorno mental, a exemplo de ansiedade e depressão, através de uma escuta qualificada, que é atribuição importante do enfermeiro nos diferentes níveis de assistência. Building the Project Mindfully: reflection on the mental health of nursing students in front of COVID-19The present experience report aims to highlight the authors’ experience in the construction of the Project Mindfully in a private university located in the city of Rio de Janeiro. The objective of this study is to point out its practical insertion, as well as, to portray the importance of a project of this magnitude in the care of the psychic health of nursing students, especially in the current context of social isolation by the pandemic of COVID-19. It is concluded that the action makes it possible to build a support network among the classmates themselves who are experiencing the same difficulties with this social isolation and alleviates situations that can maximize or trigger some type of mental disorder, such as anxiety and depression, through qualified listening, which is an important role of nurses at different levels of care.
Keeping the Learner at the Focal Point: The Use of Needs Assessment and Persona Construction to Develop an Instructional Resource Center For Instructional Designers
Authors: Stefaniak Jill , Shah Smruti , Mills Erin , Luo Tian 
Published: May 2020

This design case shares how personas were utilized to create an online career resource center intended to help instructional design students in making informed career decisions. The outcome of this project has helped identify instructional opportunities to improve services currently provided to instructional design students and graduate student members of the Association for Education Communications and Technology (AECT ). By evaluating the mechanisms and supports already in place and contrasting those with the needs of the students who are seeking career guidance, the intent of the project was to bridge the gap between graduate student members’ career needs and the resources available to them within a professional association. We discuss how
we gathered information through a needs assessment for the creation of a Career Resource Center to further educate and inform instructional design students of resources for career decision-making.
Biomarkers of male hypogonadism in childhood and adolescence
Authors: Rey Rodolfo A. 
Published: May 2020

Abstract

Objectives
The objective of this review was to characterize the use of biomarkers of male hypogonadism in childhood and adolescence.

Contents
The hypothalamic-pituitary-gonadal (HPG) axis is active during fetal life and over the first months of postnatal life. The pituitary gland secretes follicle stimulating hormone (FSH) and luteinizing hormone (LH), whereas the testes induce Leydig cells to produce testosterone and insulin-like factor 3 (INSL), and drive Sertoli cells to secrete anti-Müllerian hormone (AMH) and inhibin B. During childhood, serum levels of gonadotropins, testosterone and insulin-like 3 (INSL3) decline to undetectable levels, whereas levels of AMH and inhibin B remain high. During puberty, the production of gonadotropins, testosterone, and INSL3 is reactivated, inhibin B increases, and AMH decreases as a sign of Sertoli cell maturation.

Summary and outlook
Based on our knowledge of the developmental physiology of the HPG axis, these biomarkers can be used in clinical practice to interpret the physiopathology of hypogonadism. Additionally, these markers can have diagnostic value in different forms of hypogonadism that may appear during childhood and adolescence.
Broad spectral lines in AGNs and supermassive black hole mass measurements
Authors: Popović Luka Č. 
Published: May 2020

AbstractThe mass measurement of supermassive black holes (SMBHs) is a very complex task. Between several methods for SMBH mass measurements, some of them use the spectral lines, which indicate the motion of the emitting/absorbing material around an SMBH. Mostly, there is an assumption of virialization of line emitting gas in the region which is close to the central SMBH. In this paper we will give an overview of methods for the SMBH mass measurements using broad emission spectral lines observed in Type 1 AGNs. First we give the basic idea to use the parameters of broad lines to SMBH mass measurements. After that we give an overview of broad lines from X-ray (Fe kα) to the IR (Pashen and Brecket lines) which have been used for SMBH mass estimates. Additionally, we describe and discuss a new method for SMBH mass measurements using the polarization in the broad lines emitted from Type 1 AGNs.
Nonlinear flexural analysis of sandwich beam with multi walled carbon nanotube reinforced composite sheet under thermo-mechanical loading
Authors: Lal Achchhe , Markad Kanif 
Published: May 2020

AbstractNonlinear flexural analysis of sandwich composite beam with multiwall carbon nanotube (MWCNT) reinforced composite face sheet and bottom sheet under the thermo-mechanically induced loading using finite element method is carried out. Solution of current bending analysis is performed using Newton’s Raphson approach by using higher order shear deformation theory (HSDT) and non-linearity with Von Kármán kinematics. The sandwich laminated composite beam is subjected to uniform, linear and nonlinear varying temperature distribution through thickness of the beam. The sandwich beam with MWCNT reinforced composite facesheet and bottom sheet is subjected to point, uniformly distributed (UDL), hydrostatic and sinusoidal loading. The two phase matrix is utilized with E-Glass fiber to form three phase composite face sheet and bottom sheet by Halpin-Tsai model. The static bending analysis is performed for evaluating the transverse central deflection of three and five layered sandwich composite beam. Transverse central deflection is measured by varying CNT volume fraction, uniformly distributed, linearly and nonlinear varying temperature distribution, thickness ratio, boundary condition, number of walls of carbon nanotube by using interactive MATLAB code.
Nouveau fragment arabe du De aeternitate mundi contra Aristotelem de Jean Philopon
Authors: Rashed Marwan 
Published: May 2020

Abstract
This paper presents a new fragment of Philoponus' treatise De aeternitate mundi contra Aristotelem. The fragment, preserved only in an Arabic translation by al-Bīrūnī, derives in all probability from the third book of the treatise, and it deals with the moonstone or selenite. It is hypothesized that this mirabile, which is described by Damascius in his Life of Isidore, was deployed by Philoponus at the point of his polemic against Aristotle.
Pyrrhonism, Inquiry, and Rationality
Authors: Machuca Diego E. 
Published: May 2020

Abstract
In this paper, I critically engage with Casey Perin's interpretation of Sextan Pyrrhonism in his recent book, The Demands of Reason: An Essay on Pyrrhonian Scepticism. From an approach that is both exegetical and systematic, I explore a number of issues concerning the Pyrrhonist's inquiry into truth, his alleged commitment to the canons of rationality, and his response to the apraxia objection.
L'interpretazione del Teeteto e la natura della epistemologia platonica. Alcune osservazioni
Authors: Ferrari Franco 
Published: May 2020

Abstract
This article replies to the critical note by Trabattoni («Elenchos», xxxiii (2012) pp. 69-107). The author defends his interpretation of Plato's Theaetetus against Trabattoni's objections, arguing that the maieutic and peirastic character of the dialogue explains its negative or aporetic conclusion. For the failure of all the attempts to define knowledge in the dialogue doesn't mean that, according to Plato, knowledge is not possible for men or that it can be identified with doxa; on the contrary, Plato clearly states that the philosopher, i.e. the dialectician, is absolutely able to attain the perfect knowledge of the forms. The subsequent failures in the Theaetetus, particularly the last two, depend on the admission of an "additive model'' according to which knowledge is "doxa plus something'', an epistemological attitude that is explicitly rejected in the Meno.
Stasis del alma y psicologización de la política en República IV
Authors: Soares Lucas 
Published: May 2020

Abstract
In Republic 436a-c Plato introduces, for the first time, the problematic postulate of the tripartition of the species-functions of the soul to pass on to justify it by starting from the so-called “Principle of conflict” or “of the impossibility of opposites”. To reach this point in the dialogue, we will firstly place this passage in the conceptual architecture of the work, taking the topic of stasis (sedition, revolt, civil war) as the thread for the reconstruction of the argumentative sequence that leads into the psychological model of the parts in conflict. We actually start from the hypothesis that Plato gets to the tripartition of the soul from the evidence that in the psychological reality of the individual there exists a stasis that is produced in the soul due to injustice, contrasting to the concord and friendship that is a result of justice. On the basis of the psychological model of the parts in conflict, the psycho-political objective looked for in Republic, points to the achievement of the psychic unity as a condition for the political unity; since Plato’s political objective is to make citizens become better, which can only be reached through an improvement of the individual soul. Through the topic of stasis and the lexis of the conflict that derives from it, we uphold that Plato intends to prove not only the political and tripartite constitution of the soul, but first and foremost the priority that the psychic tripartition holds over the political order.
Knowing by Doing: The Role of Geometrical Practice in Aristotle’s Theory of Knowledge
Authors: Ugaglia Monica 
Published: May 2020

Abstract
Aristotle’s way of conceiving the relationship between mathematics and other branches of scientific knowledge is completely different from the way a contemporary scientist conceives it. This is one of the causes of the fact that we look at the mathematical passages we find in Aristotle’s works with the wrong expectation. We expect to find more or less stringent proofs, while for the most part Aristotle employs mere analogies. Indeed, this is the primary function of mathematics when employed in a philosophical context: not a demonstrative tool, but a purely analogical model. In the case of the geometrical examples discussed in this paper, the diagrams are not conceived as part of a formalized proof, but as a work in progress. Aristotle is not interested in the final diagram but in the construction viewed in its process of development; namely in the figure a geometer draws, and gradually modifies, when he tries to solve a problem. The way in which the geometer makes use of the elements of his diagram, and the relation between these elements and his inner state of knowledge is the real feature which interests Aristotle. His goal is to use analogy in order to give the reader an idea of the states of mind involved in a more general process of knowing.
Pyrrhonian Relativism
Authors: Machuca Diego 
Published: May 2020

Abstract
This paper argues that Sextus Empiricus’s Pyrrhonism is a form of relativism markedly different from the positions typically referred to by this term. The scholars who have explored the relativistic elements found in Sextus’s texts have claimed that his outlook is not actually a form of relativism, or that those elements are inconsistent with his account of Pyrrhonism, or that he is confusing skepticism with relativism. The reason for these views is twofold: first, when employing the term “relativism” one hardly has in mind the sort of relativistic stance adopted by the Pyrrhonist; and second, those scholars have misinterpreted Sextus’s relativistic remarks. The purpose of this paper is to show that he adopts a phenomenological kind of relativism that is compatible with his account of Pyrrhonism.
Il confronto di Giovanni Filopono con Alessandro di Afrodisia intorno al problema della conversione delle proposizioni
Authors: Gili Luca 
Published: May 2020

Abstract
In this paper I compare Philoponus’s account of the laws of conversion for categorical and modal propositions with Alexander’s exposition of the same topic. I argue that Philoponus’s main source was Alexander’s commentary on Aristotle’s Prior Analytics and that Philoponus had no access to independent sources to reconstruct Theophrastus’s proof for the conversion of universal negative propositions. I suggest that the different solutions that Alexander and Philoponus offer to the puzzles of the doctrine of the laws of conversion depend on the two commentators’ different exegetical strategies. Alexander tries to solve the puzzles by means of doctrines, which Aristotle expounded elsewhere. Philoponus instead interprets Aristotle’s passage as implying a hierarchy among propositions - a doctrine which is not explicitly present in Aristotle’s text.