bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Early and Long-Term Effects of Piezosurgery With Conventional Techniques for Osteotomies in Rhinoplasty
Authors: Aydoğdu Imran , Bayram Ali Alper 
Published: March 2020

Objective:
Osteotomy is a critical step of rhinoplasty. Various osteotomy techniques have been developed to reduce postoperative edema and ecchymosis and achieve optimal aesthetic results. In this study, we aimed to compare the early and long-term effects of piezoelectric surgery with conventional osteotomy.

Methods:
In this prospective study, 72 rhinoplasty patients were randomly divided into 2 groups according to osteotomy technique used, either conventional osteotomy or piezosurgery. These 2 groups were compared for postoperative edema, ecchymosis, and pain on the first and seventh postoperative days. The sinonasal outcome test-22 (SNOT-22), peak nasal flowmetry, and Connecticut Chemosensory Clinical Research Center test were applied to all patients before and 8 weeks after surgery.

Results:
The study consisted of 72 patients, 42 of whom were female and 30 were male. The mean age was 28.1 ± 6.5 (range 18–49 years). On the first postoperative day, edema and ecchymosis were significantly less in the piezosurgery group (P < 0.001). VAS results showed that only the piezosurgery group experienced less pain on the first postoperative day (P < 0.001). Nasal airflow of the patients was evaluated preoperatively and postoperatively, nasal airflow decreased postoperatively in both groups, but this decrease was not statistically significant, and no significant difference was found between the groups. The preoperative and postoperative comparison of odor functions was similar in both groups after the operation, and there was no significant difference between the groups.

Conclusion:
Piezosurgery in the early period after rhinoplasty has been shown to decrease eyelid edema, periorbital ecchymosis, and pain compared to conventional osteotomy techniques. However, the superiority of piezosurgery in terms of nasal airflow, olfactory functions and quality of life were not found in the long term.
Hyoid Bone Position and Head Posture in Patients With Richieri-Costa Pereira Syndrome (EIF4A3 Mutations)
Authors: Pinto Rayane de Oliveira , Peixoto Adriano Porto , Pinto Ary dos Santos , Richieri-Costa Antonio , Raveli Dirceu Barnabé , Tonello Cristiano , Dalben Gisele da Silva 
Published: March 2020

Abstract
Robin sequence with cleft mandible and limb anomalies, known as Richieri-Costa-Pereira syndrome (RCPS), is an autosomal recessive acrofacial dysostosis characterized by mandibular cleft and other craniofacial anomalies and respiratory complications. The aim of this cross-sectional study was to describe the hyoid and head posture of 9 individuals with RCPS using cephalometric measurements and provide a discussion about its implications in obstructive sleep apnea syndrome (OSAS). The study was conducted on lateral cephalograms of patients with RCPS and 9 selected age-matched controls in tertiary cleft center in Brazil. The cephalograms were digitized and analyzed on a software to obtain the vertical and horizontal hyoid position, its relationship with the mandible and the relation of the cranial base and postvertebral line. The t test was used for analysis of means and Levene's test for equality of variances.
Cephalometric measurements H-S (vertical distance between hyoid bone and sella) (Supplemental Digital Content, Figure 1, http://links.lww.com/SCS/B247) and H-C4lp (horizontal position of the hyoid in relation to the post-pharyngeal space) showed statistically significant difference compared to controls (P < 0.05). Therefore, the hyoid bone was more inferiorly and posteriorly positioned in the study group compared with the control group. The vertebrae measurements did not present differences compared to controls. The described position of hyoid bone could be involved in the severe OSAS of RCPS patients.
Shrapnel Injuries on Regions of Head and Neck in Syrian War
Authors: Ucak Murat 
Published: March 2020

Background:
Perforating and cutting injuries to the head and neck due to shrapnels are largely life-threatening and require immediate medical attention. In the present article, the surgical conditions in the war-related head and neck injuries were presented in terms of war surgery with mortality rates.

Materials and Methods:
The study was designed as a retrospective clinical case-control study including primarily 179 head and neck injuries that occurred due to shrapnels in the Syrian Civil War. The records of 2015–2019 years were analyzed according to demographics, injury types, injury location, plastic surgery approaches and postoperative outcomes.

Results:
Injury mechanism of all wounds was penetrating type, which was commonly secondary to an explosive device, collapse due to shrapnels of the explosion, gunshot or grenade. While 43(24%) of the wounded were soldiers, 136 (76%) were civilians. Considering the reason for the shrapnel injury, 83% was due to the explosion and 17% was due to gunshot injuries. The 32% showed facial fractures. As the most common fractures of the face were around the maxilla-zygoma (28.4%), orbita (22%), and teeths (18.5%). Considering neck injury zones, region-2 was mostly affected by the region. The third zone had the lowest rate of injury with 10%. In 89 (49%) patients, the authors preferred primary, while 15 gained secondary reconstruction (8%). The authors used Limberg flap for 24 (32%) patients, rotation flap for 39 (52%) patients, and bilobe flap for 12 (16%) patients.

Conclusion:
The most important cause of mortality was not the destruction, tissue loss caused by shrapnel injury, or experience of the surgeon, but the severe states of sepsis or multiple different trauma when brought for treatment from long range from the war zone.
Isolated Frontosphenoidal Suture Craniosynostosis: Treatment Approaches and Literature Review for a Unique Condition
Authors: Puente-Espel Jordi , Kozusko Steven D. , Konofaos Petros , Boop Frederick A. , Wallace Robert D. 
Published: March 2020

Background:
Craniosynostosis isolated to the frontosphenoidal suture is an extremely rare entity, distinct from other types of synostotic anterior plagiocephaly, from the embryologic, phenotypic and endocranial morphology viewpoints. Embryologically, the sphenoid bone has two origins, which morphogenetically represent 2 distinct subunits. Depending on the region involved, unique craniofacial features involving the forehead, temporal region and orbit will be demonstrated. A case of frontosphenoidal suture synostosis depicting these features is presented. In addition, a literature review was performed and a treatment algorithm is proposed.
Effectiveness of Interprofessional Manikin-Based Simulation Training on Teamwork Among Real Teams During Trauma Resuscitation in Adult Emergency Departments
Authors: Lapierre Alexandra , Bouferguene Sabrina , Gauvin-Lepage Jérôme , Lavoie Patrick , Arbour Caroline 
Published: March 2020

Summary Statement
This systematic review synthesizes the relevant evidence about the effectiveness of interprofessional manikin-based simulation training on teamwork among real teams during trauma resuscitation in adult civilian emergency departments. A systematic literature search was conducted in MEDLINE, CINAHL, EMBASE, EBM reviews, PsycINFO, and Web of Science with no time limit. Only experimental and quasi-experimental studies were included. Effects of the simulation intervention on teamwork were categorized according to a modified version of the Kirkpatrick's model. From the 1120 studies found, 11 studies were included for synthesis. All studies showed immediate improvement in teamwork after training, but divergent results were found regarding skills retention. Although this review focused on interprofessional manikin-based simulations in real trauma teams, the results are similar to previous systematic reviews including different types of simulation. This raises significant questions regarding the importance of simulation design characteristics to improve teamwork in trauma care.
Reasons Behind Preferences for Community-Based Continence Promotion
Authors: Brown Heidi W. , Wise Meg E. , LeCaire Tamara J. , Braun Emilie J. , Drewry Anna M. , Buttigieg Emily M. , Macco Maria , Barnet Jodi H. , Bersch Andrew , Peppard Paul E. , Malecki Kristen M.C. , Nieto F. Javier , Mahoney Jane E. 
Published: March 2020

Objectives
This study aimed to understand the potential reach of continence promotion intervention formats among incontinent women.

Methods
The Survey of the Health of Wisconsin conducts household interviews on a population-based sample. In 2016, 399 adult women were asked about incontinence and likelihood of participation in continence promotion via 3 formats: single lecture, interactive 3-session workshop, or online. Descriptive analyses compared women likely versus unlikely to participate in continence promotion. To understand format preferences, modified grounded theory was used to conduct and analyze telephone interviews.

Results
One hundred eighty-seven (76%) of 246 incontinent women reported being likely to attend continence promotion: 111 (45%) for a single lecture, 43 (17%) for an interactive 3-session workshop, and 156 (64%) for an online program. Obesity, older age, nonwhite race, prior health program participation, and Internet use for health information were associated with reported continence promotion participation. Cited advantages of a single lecture included convenience and ability to ask questions. A workshop offered accountability, hands-on learning, and opportunity to learn from others; online format offered privacy, convenience, and self-directed learning.

Conclusions
Most incontinent women are willing to participate in continence promotion, especially online.
Direct to operating room trauma resuscitation: Optimizing patient selection and time-critical outcomes when minutes count
Authors: Johnson Amelia , Rott Michael , Kuchler Andrea , Williams Emma , Cole Fredrick , Ramzy Ameen , Barbosa Ronald , Long William , Martin Matthew J. 
Published: March 2020

BACKGROUND
Although several trauma centers have developed direct to operating room (DOR) trauma resuscitation programs, there is little published data on optimal patient selection, practices, and outcomes. We sought to analyze triage criteria and interventions associated with optimal DOR outcomes and resource utilization.

METHODS
Retrospective review of all adult DOR resuscitations for a 6-year period was performed. Triage criteria were analyzed individually and grouped into categories: mechanism, physiology, anatomy/injury, or other. The best univariate and multivariate predictors of requiring lifesaving interventions (LSIs) or emergent surgery (ES) were analyzed. Actual and predicted mortality were compared for all patients and for predefined time-sensitive subgroups.

RESULTS
There were 628 DOR patients (5% of all admissions) identified; the majority were male (79%), penetrating mechanism (70%), severely injured (40% ISS >15), and 17% died. Half of patients required LSI and 23% required ES, with significantly greater need for ES and lower need for LSI after penetrating versus blunt injury (p < 0.01). Although injury mechanism criteria triggered most DOR cases and best predicted need for ES, the physiology and anatomy/injury criteria were associated with greater need for LSI and mortality. Observed mortality was significantly lower than predicted mortality with DOR for several key subgroups. Triage schemes for both ES and LSI could be simplified to four to six independent predictors by regression analysis.

CONCLUSION
The DOR program identified severely injured trauma patients at increased risk for requiring LSI and/or ES. Different triage variable categories drive the need for ES versus LSI and could be simplified or optimized based on local needs or preferences. Direct to operating room was associated with better than expected survival among specific time-sensitive subgroups.

LEVEL OF EVIDENCE
Therapeutic/Care Management, Level IV.
“My Parent’s Body Is Sacred”
Authors: Montoya Yadira , Balbim Guilherme M. , Glover Crystal M. , Marquez David X. 
Published: March 2020

Introduction:
Brain donation is a critical part of advancing research addressing Alzheimer disease and related dementias (ADRD). Studies on ADRD with an option for brain donation are reliant on family members to fulfill the research participant’s plan for brain donation. Thus, family members play a pivotal role in increasing brain donation rates, particularly among under-represented groups.

Methods:
This study examines knowledge, attitudes, and beliefs about brain donation for research among Latinos. Latino men (N=4) and Latina women (N=11) 18 years of age or older with a parental figure age 65 years and over were invited to participate in a focus group.

Results:
Data analyses revealed 3 themes. Two themes focused on factors influencing a family’s willingness to support brain donation: (a) social and cultural contexts, and (b) lack of knowledge and information about the brain donation process. The last theme provided recommendations for engaging older Latino adults in ADRD research and brain donation.

Discussion:
Results suggest being inclusive of family members during all stages of the research process, from recruitment to dissemination. In addition, addressing information gaps among Latinos about the process and benefits of brain donation may help mitigate mistrust and misperceptions and increase participation rates in brain donation.
Preventing respiratory illness in older adults aged 60 years and above living in long-term care
Authors: Rios Patricia , Radhakrishnan Amruta , Thomas Sonia M. , Darvesh Nazia , Straus Sharon E. , Tricco Andrea C. 
Published: March 2020

ABSTRACTBackgroundThe overall objective of this rapid overview of reviews (overview hereafter) was to identify evidence from systematic reviews (SRs) for infection control and prevention practices for adults aged 60 years and older in long-term care settings.MethodsComprehensive searches in MEDLINE, EMBASE, the Cochrane Library, biorxiv.org/medrxiv.org, clinicaltrials.gov and the Global Infectious Disease Epidemiology Network (GIDEON) were carried out in early March 2020. Title/abstract and full-text screening, data abstraction, and quality appraisal (AMSTAR 2) were carried out by single reviewers.ResultsA total of 6 SRs published between 1999 and 2018 were identified and included in the overview. The SRs included between 1 and 37 primary studies representing between 140 to 908 patients. All of the primary studies included in the SRs were carried out in long-term care facilities (LTCF) and examined pharmacological, non-pharmacological, or combined interventions. One high quality SR found mixed results for the effectiveness of hand hygiene to prevent infection (2 studies statistically significant positive results, 1 study non-statistically significant results). One moderate quality SR with meta-analysis found a moderate non-statistically significant effect for personal protective equipment (PPE) in preventing infection and found no statistically significant results for the effectiveness of social isolation. One moderate quality SR reported statically significant evidence for the effectiveness of amantadine and amantadine + PPE to prevent infection with respiratory illness in LTCF.ConclusionThe current evidence suggests that with antiviral chemoprophylaxis with adamantine is effective in managing respiratory illness in residents of long-term care facilities. The rest of the strategies can be used in long-term care facilities, yet have limited evidence supporting their use from systematic reviews.
Identify potent SARS-CoV-2 main protease inhibitors via accelerated free energy perturbation-based virtual screening of existing drugs
Authors: Li Zhe , Li Xin , Huang Yi-You , Wu Yaoxing , Liu Runduo , Zhou Lingli , Lin Yuxi , Wu Deyan , Zhang Lei , Liu Hao , Xu Ximing , Yu Kunqian , Zhang Yuxia , Cui Jun , Zhan Chang-Guo , Wang Xin , Luo Hai-Bin 
Published: March 2020

AbstractCoronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global crisis. There is no therapeutic treatment specific for COVID-19. It is highly desirable to identify potential antiviral agents against SARS-CoV-2 from existing drugs available for other diseases and, thus, repurpose them for treatment of COVID-19. In general, a drug repurposing effort for treatment of a new disease, such as COVID-19, usually starts from a virtual screening of existing drugs, followed by experimental validation, but the actual hit rate is generally rather low with traditional computational methods. Here we report a new virtual screening approach with accelerated free energy perturbation-based absolute binding free energy (FEP-ABFE) predictions and its use in identifying drugs targeting SARS-CoV-2 main protease (Mpro). The accurate FEP-ABFE predictions were based on the use of a new restraint energy distribution (RED) function designed to accelerate the FEP-ABFE calculations and make the practical FEP-ABFE-based virtual screening of the existing drug library possible for the first time. As a result, out of twenty-five drugs predicted, fifteen were confirmed as potent inhibitors of SARS-CoV-2 Mpro. The most potent one is dipyridamole (Ki=0.04 μM) which has showed promising therapeutic effects in subsequently conducted clinical studies for treatment of patients with COVID-19. Additionally, hydroxychloroquine (Ki=0.36 μM) and chloroquine (Ki=0.56 μM) were also found to potently inhibit SARS-CoV-2 Mprofor the first time. We anticipate that the FEP-ABFE prediction-based virtual screening approach will be useful in many other drug repurposing or discovery efforts.Significance StatementDrug repurposing effort for treatment of a new disease, such as COVID-19, usually starts from a virtual screening of existing drugs, followed by experimental validation, but the actual hit rate is generally rather low with traditional computational methods. It has been demonstrated that a new virtual screening approach with accelerated free energy perturbation-based absolute binding free energy (FEP-ABFE) predictions can reach an unprecedently high hit rate, leading to successful identification of 16 potent inhibitors of SARS-CoV-2 main protease (Mpro) from computationally selected 25 drugs under a threshold of Ki= 4 μM. The outcomes of this study are valuable for not only drug repurposing to treat COVID-19, but also demonstrating the promising potential of the FEP-ABFE prediction-based virtual screening approach.
Are there Physical Linkages between Genes that have Synergistic Fitness Effects?
Authors: Byrnes Juliet , Murray John , Tanaka Mark M. , Goldys Ben , Bellanto Antony , Cayetano Luis , Sherwin William 
Published: March 2020

AbstractMany of the effects on fitness in population genetics are due not to single locations in the genome, but to the interaction of genetic variants at multiple locations in the genome. Of particular interest are ‘completely epistatic’ interactions, where a combination of genetic variants is required to produce an effect, and the effect cannot occur with any other combination. In diploids, epistasis is strongly connected to meiotic recombination, a process which can both assemble and destroy beneficial combinations of genetic variants. Additionally, epistatic interactions can be hard to detect in empirical studies, and mathematical models of epistasis and recombination are challenging to analyse, so despite their ubiquity epistatic interactions are regularly not considered. As a result, there is little consensus on when high levels of recombination might be expected, or how strongly recombination affects beneficial or deleterious fitness effects controlled by epistatic interactions. We address this question by conducting a meta-analysis and simulations. The meta-analysis used data drawn and curated fromDrosophila melanogasterstudies in Flybase. We extracted studies relating genetic combinations and phenotypically detectable effects on fitness, then analysed the relationship between the rate of recombination and effect on fitness with a statistical model. We also ran simulations under a two-locus Wright-Fisher model with recombination and epistatic selection. The results of both approaches indicated a tendency for genetic combinations with an epistatic effect on fitness to occur in an environment of reduced meiotic recombination. Two possible explanations for this are that the variants controlling such interactions are selected for in regions where there is little recombination, or that such interactions lead to selection for lower rates of recombination in the regions where those variants appear.
CHARACTERIZATION OF THE PROPORTION OF CLUSTERED TUBERCULOSIS CASES IN GUATEMALA, CA: INSIGHTS FROM A MOLECULAR EPIDEMIOLOGY STUDY, 2010-2014
Authors: Castellanos María Eugenia , Lau-Bonilla Dalia , Moller Anneliese , Arathoon Eduardo , Quinn Frederick D. , Ebell Mark H. , Dobbin Kevin K. , Samayoa Blanca , Whalen Christopher C. 
Published: March 2020

ABSTRACTBackgroundThere is little information about the proportion of clustering of tuberculosis cases from low-income settings, which can represent ongoing transmission events. We investigated for the first time the proportion of clustered tuberculosis cases based on genotypic matching in Guatemala City, Guatemala between 2010 and 2014 and potential risk factors associated with these clustered cases in HIV-infected subjects. Moreover, the genetic diversity of M. tuberculosis isolates in this country is presented.Design and methodsThis study was a retrospective observational study conducted on Mycobacterium tuberculosis isolates from HIV-infected and non-HIV infected tuberculosis cases that submitted samples to a referral tuberculosis laboratory in Guatemala City, Guatemala from 2010-2014. Genotyping results were compared with the international spoligotyping database, SITVIT2 and classified accordingly. We generated a spoligoforest using the MERCAT program. We categorized spoligotype patterns as clustered or non-clustered depending of their genotype and estimated the proportion of clustering and the recent transmission index (RTIn-1). We analyzed the crude association between demographic, clinical and behavioral variables and clustering in the HIV-population.ResultsFrom 2010 to 2014, a total of 479 patients were confirmed as tuberculosis cases by culture at the study site. Spoligotype patterns were available from 391 patients (82%), nine of them with two isolates included in the study. We detected 71 spoligotype patterns and overall, the most frequent spoligotyping families were LAM (39%), followed by T (22%), Haarlem (14%), X (13%), Unknown (6%) and Beijing (3%), representing 97% of the isolates. Out of the 400 isolates, 365 (91%) were grouped in 36 clusters (range: 2-92). The recent transmission index (RTIn-1) was 82%. Pulmonary tuberculosis was strongly associated with clustering in the 113 HIV-infected group with available data (OR=4.3, 95% CI 1.0-17.7).ConclusionThere might be high levels of ongoing transmission of M. tuberculosis in Guatemala City, Guatemala as indicated by clustering in a convenience sample. Among HIV-infected patients, clustering was more likely in pulmonary disease.