bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Life Stress, Frontoamygdala Connectivity, and Biological Aging in Adolescence: A Longitudinal Investigation
Authors: Miller Jonas G , Ho Tiffany C , Humphreys Kathryn L , King Lucy S , Foland-Ross Lara C , Colich Natalie L , Ordaz Sarah J , Lin Jue , Gotlib Ian H 
Published: February 2020

Abstract
Early life stress (ELS) may accelerate frontoamygdala development related to socioemotional processing, serving as a potential source of resilience. Whether this circuit is associated with other proposed measures of accelerated development is unknown. In a sample of young adolescents, we examined the relations among ELS, frontoamygdala circuitry during viewing of emotional faces, cellular aging as measured by telomere shortening, and pubertal tempo. We found that greater cumulative severity of ELS was associated with stronger negative coupling between bilateral centromedial amygdala and the ventromedial prefrontal cortex, a pattern that may reflect more mature connectivity. More negative frontoamygdala coupling (for distinct amygdala subdivisions) was associated with slower telomere shortening and pubertal tempo over 2 years. These potentially protective associations of negative frontoamygdala connectivity were most pronounced in adolescents who had been exposed to higher ELS. Our findings provide support for the formulation that ELS accelerates maturation of frontoamygdala connectivity and provide novel evidence that this neural circuitry confers protection against accelerated biological aging, particularly for adolescents who have experienced higher ELS. Although negative frontoamygdala connectivity may be an adaptation to ELS, frontoamygdala connectivity, cellular aging, and pubertal tempo do not appear to be measures of the same developmental process.
Serious Infectious Events and Immunoglobulin Replacement Therapy in Patients With Autoimmune Disease Receiving Rituximab: A Retrospective Cohort Study
Authors: Stabler Sarah , Giovannelli Jonathan , Launay David , Cotteau-Leroy Angélique , Heusele Marion , Lefèvre Guillaume , Terriou Louis , Lambert Marc , Dubucquoi Sylvain , Hachulla Eric , Sobanski Vincent 
Published: February 2020

Abstract

Background
Rituximab (RTX) is widely administered to patients with autoimmune disease (AID). This study aimed to estimate the incidence of serious infectious events (SIEs) after RTX initiation in patients with AID. We also described the characteristics and risk factors of SIEs, and immunoglobulin replacement therapy (IgRT) strategies.

Methods
Patients treated between 2005 and 2016 were included in this retrospective monocentric cohort study. An RTX course was defined as the complete RTX treatment regimen received by a given patient for AID. SIEs and IgRT were right-censored at 24 months after RTX initiation.

Results
Two hundred twenty-one patients were included (corresponding to 276 RTX courses). Reasons for RTX initiation included connective tissue disease (38%), systemic vasculitis (36%), and autoimmune cytopenia (22%). The 1- and 2-year incidences of SIEs were 17.3 (95% confidence interval [CI], 12.0–22.5) and 11.3 (95% CI, 8.1–14.5) per 100 person-years, respectively. Forty-seven SIEs were observed, mostly comprising pneumonias (45%) and bacteremias (21%). When documented, the microorganisms were bacterial (55%) and fungal (12%). Identified risk factors of SIEs were age, history of diabetes, history of cancer, concomitant steroid treatment, and low CD4 lymphocyte count at RTX initiation. IgRT was started in 22 RTX courses (8%).

Conclusions
In patients with AID treated with RTX, the 1- and 2-year incidence of SIE was 17.3 and 11.3 per 100 person-years, respectively. Reports of SIE characteristics, risk factors, and IgRT strategies highlight the need for an appropriate and individualized assessment prior to and following RTX to prevent SIEs, particularly in patients with comorbidities.
Modeling Combination Hepatitis C Virus Treatment and Prevention Strategies in a Network of People Who Inject Drugs in the United States
Authors: Zelenev Alexei , Li Jianghong , Shea Portia , Hecht Robert , Altice Frederick L 
Published: February 2020

Abstract

Background
Hepatitis C virus (HCV) treatment as prevention (TasP) strategies can contribute to HCV microelimination, yet complimentary interventions such as opioid agonist therapies (OAT) with methadone or buprenorphine and syringe services programs (SSPs) may improve the prevention impact. This modeling study estimates the impact of scaling up the combination of OAT and SSPs with HCV TasP in a network of people who inject drugs (PWID) in the United States.

Methods
Using empirical data from Hartford, Connecticut, we deployed a stochastic block model to simulate an injection network of 1574 PWID. We used a susceptible-infected model for HCV and human immunodeficiency virus to evaluate the effectiveness of several HCV TasP strategies, including in combination with OAT and SSP scale-up, over 20 years.

Results
At the highest HCV prevalence (75%), when OAT coverage is increased from 10% to 40%, combined with HCV treatment of 10% per year and SSP scale up to 40%, the time to achieve microelimination is reduced from 18.4 to 11.6 years. At the current HCV prevalence (60%), HCV TasP strategies as low as 10% coverage per year may achieve HCV microelimination within 10 years, with minimal impact from additional OAT scale-up. Strategies based on mass initial HCV treatment (50 per 100 PWID the first year followed by 5 per 100 PWID thereafter) were most effective in settings with HCV prevalence of 60% or lower.

Conclusions
Scale-up of HCV TasP is the most effective strategy for microelimination of HCV. OAT scale-up, however, scale-up may be synergistic toward achieving microelimination goals when HCV prevalence exceeds 60% and when HCV treatment coverage is 10 per 100 PWID per year or lower.
Time-Course of Grammatical Processing in Deaf Readers: An Eye-Movement Study
Authors: Gómez-Merino Nadina , Fajardo Inmaculada , Ferrer Antonio , Arfé Barbara 
Published: February 2020

Abstract
Twenty participants who were deaf and 20 chronological age-matched participants with typical hearing (TH) (mean age: 12 years) were asked to judge the correctness of written sentences with or without a grammatically incongruent word while their eye movements were registered. TH participants outperformed deaf participants in grammaticality judgment accuracy. For both groups, First Pass and Total Fixation Times of target words in correct trials were significantly longer in the incongruent condition than in the congruent one. However, whereas TH students showed longer First Pass in the target area than deaf students across congruity conditions, deaf students made more fixations than their TH controls. Syntactic skills, vocabulary, and word reading speeds (measured with additional tests) were significantly lower in deaf students but only syntactic skills were systematically associated to the time-course of congruity processing. These results suggest that syntactic skills could have a cascading effect in sentence processing for deaf readers.
Probabilistic forecasting of bubbles and flash crashes
Authors: Banerjee Anurag , Chevillon Guillaume , Kratz Marie 
Published: February 2020

SummaryWe propose a near-explosive random coefficient autoregressive model (NERC) to obtain predictive probabilities of the apparition and devolution of bubbles. The distribution of the autoregressive coefficient of this model is allowed to be centred at an O(T−α) distance of unity, with α ∈ (0, 1). When the expectation of the autoregressive coefficient lies on the explosive side of unity, the NERC helps to model the temporary explosiveness of time series and obtain related predictive probabilities. We study the asymptotic properties of the NERC and provide a procedure for inference on the parameters. In empirical illustrations, we estimate predictive probabilities of bubbles or flash crashes in financial asset prices.
Abundance of the Sugarcane Borer (Lepidoptera: Crambidae) and Foraging Ants (Hymenoptera: Formicidae) in Sugarcane Grown on Organic and Mineral Soils in Florida
Authors: Roldán Erik L , Beuzelin Julien M , VanWeelden Matthew T , Cherry Ronald H 
Published: February 2020

AbstractA study was conducted in Florida to determine sugarcane borer, Diatraea saccharalis (F.), injury and infestation levels in sugarcane (Saccharum spp. hybrids), D. saccharalis parasitism rates, and ant foraging activity in 32 commercial fields as affected by soil type (shallow organic vs deep organic vs mineral). In 2017 and 2018, each field was sampled four times during the summer for D. saccharalis by inspecting 100 sugarcane stalks and for foraging ants using plastic tubes baited with hot dog at 12 locations. One non-parasitized D. saccharalis larva was collected in 2017 and in 2018 out of 12,100 and 12,600 stalks sampled, respectively. Additional sampling of 50 stalks per field in October showed that 0.6% (2017) and 0.1% (2018) of the sugarcane stalks had bored internodes, and one Cotesia flavipes (Cameron) (Hymenoptera: Braconidae) cocoon mass was observed. Seven ant species foraged in sugarcane fields, including the red imported fire ant, Solenopsis invicta Buren, which was the most abundant ant. Solenopsis invicta was not affected by soil type; however, sugarcane fields on shallow organic soils might represent a more suitable environment. The third most abundant foraging ant, Nylanderia bourbonica (Forel), was more abundant in mineral soil fields than in shallow and deep organic soil fields. Results suggest that D. saccharalis population levels in Florida sugarcane are extremely low under current production conditions regardless of soil type. In addition, the observation of C. flavipes, S. invicta, and six other ant species suggest that biological control contributes to these low D. saccharalis population levels.
Difficult diagnosis of cardiac haemochromatosis: a case report
Authors: Sudmantaitė Vaida , Čelutkienė Jelena , Glaveckaite Sigita , Katkus Rimgaudas 
Published: February 2020

Abstract

Background
Primary iron overload cardiomyopathy is an important and potentially preventable cause of heart failure (HF), usually manifesting in the 4–5th decade of life. Patients may be asymptomatic early in the disease with hidden progression of cardiac dysfunction. The challenge of timely detection is an awareness of this systemic disorder and an adequate degree of clinical vigilance.

Case summary
A 48-year-old man was referred to the university clinic due to the episode of atrial fibrillation. The specific features of bronze skin and yellow eyes together with a combination of syndromes (cardiomyopathy, cirrhosis, ascites and portal hypertension, diabetes mellitus, and chronic kidney disease) stimulated the testing of iron metabolism markers, which were far above the normal range. Echocardiography and cardiac magnetic resonance (CMR) showed the dilatation of all cardiac cavities and biventricular systolic dysfunction. CMR T2* mapping was consistent with the diagnosis of myocardial and hepatic siderosis. Hereditary Type I haemochromatosis was confirmed by a genetic test. After 6 months of standard HF treatment, chelation therapy with deferiprone and regular phlebotomies imaging tests showed a reduction of ventricular and atrial volumes, an improvement in the cardiac systolic function and a decrease of iron accumulation.

Discussion
In this case, complicating syndromes were detected earlier than underlying disease of primary haemochromatosis. Cardiac haemochromatosis should be considered in any patient with unexplained HF, especially in the case of a positive family history, abnormal liver enzymes, endocrinopathies, or evidence of involvement of other organ systems. Screening for systemic iron overload with transferrin saturation and serum ferritin is the first step. Further non-invasive imaging tests should be done to confirm organ involvement.
Operationalizing triple bottom line harvest strategies
Authors: Dichmont Catherine M , Dowling Natalie A , Pascoe Sean , Cannard Toni , Pears Rachel J , Breen Sian , Roberts Tom , Leigh George M , Mangel Marc 
Published: February 2020

Abstract
Over the past 50 years, the diversity of fisheries types being actively managed has changed from mainly data-rich, industrial sectors to more socially, economically, and environmentally complex multispecies and multisector fisheries. Accompanying this change has been a broadening of management objectives to include social and economic considerations with traditional resource sustainability objectives, the so-called triple bottom line, and the need to include these considerations into harvest strategies. The case of a line fishery in Australia’s Great Barrier Reef is used as a demonstration of the first steps in implementing triple bottom line harvest strategies. This fishery has several disparate sectors including commercial, tourism, and recreation; targets multiple but important reef species; and is undertaken in a World Heritage Site. This work highlights the need for a much-expanded set of objectives elicited from stakeholders that are either included in the trade-off analyses of the different harvest strategies or directly in an optimization. Both options demonstrated that a paradigm shift is required to emphasize representative participatory management systems that assemble teams from quite different backgrounds and viewpoints; use much broader set of objectives; and modify tools and (especially) the data collected within revised monitoring programmes to underpin these tools.
The Elliptic Tail Kernel
Authors: Cuenca Cesar , Gorin Vadim , Olshanski Grigori 
Published: February 2020

AbstractWe introduce and study a new family of $q$-translation-invariant determinantal point processes on the two-sided $q$-lattice. We prove that these processes are limits of the $q$–$zw$ measures, which arise in the $q$-deformation of harmonic analysis on $U(\infty )$, and express their correlation kernels in terms of Jacobi theta functions. As an application, we show that the $q$–$zw$ measures are diffuse. Our results also hint at a link between the two-sided $q$-lattice and rows/columns of Young diagrams.
Disposable Cartridge Extraction of Retinol and Alpha-Tocopherol from Fatty Samples
Authors: Bourgeois Claude Fernand , Ciba Nadine 
Published: February 2020

Abstract
A new approach is proposed for liquid/solid extraction of retinol and α-tocopherol from samples, using a disposable kieselguhr cartridge. The substitution of the mixture methanol-ethanol-n-butanol (4 + 3 + 1) for methanol in the alkaline hydrolysis solution makes it now possible to process fatty samples. Methanol is necessary to solubilize the antioxidant ascorbic acid, and a linear chain alcohol such as n-butanol is necessary to reduce the size of soap micelles so that they can penetrate into the kieselguhr pores. In comparisons of the proposed method with conventional methods on mineral premixes and fatty feedstuffs, recovery and accuracy are at least as good by the proposed method. Advantages are increased rate of determinations and the ability to hydrolyze and extract retinol and α-tocopherol together from the same sample.
Determination of Ammonium Ion in Povidone by Derivatization and Square Wave Voltammetry
Authors: Ianniello Robert M 
Published: February 2020

Abstract
A rapid and precise method is described for the determination of residual ammonium ion in povidone (polyvinylpyrrolidone). Formaldehyde reacts with ammonium ion at pH 4 to yield hexamethylenetetramine, which is reducible at ca −0.9 V vs Ag/AgCl. The derivative is detected using square wave voltammetry and is quantitated by the method of standard additions.
Rapid Determination of Aflatoxins in Raw Peanuts by Liquid Chromatography with Postcolumn Iodination and Modified Minicolumn Cleanup
Authors: Dorner Joe W , Cole Richard J 
Published: February 2020

Abstract
A method is described for rapid cleanup followed by reverse-phase liquid chromatographic (LC) quantitation of aflatoxins in raw peanuts. A modified minicolumn cleanup is used for sample preparation, and a preliminary estimation of aflatoxin content by minicolumn can be made so that highly contaminated samples can be diluted before LC analysis. The use of the simple, quick minicolumn cleanup eliminates the need for further column or cartridge cleanup, thus greatly reducing sample preparation time. Sensitive quantitation is achieved using a phenyl column, a mobile phase of water-tetrahydrofuran (80 + 20, v/v), and postcolumn derivatization with water-saturated iodine followed by fluorescence detection. The recoveries of aflatoxins B1, B2, G1, and G2 from peanut meal spiked at 3 levels ranged from 71.7 to 88.3% (average 80%) with coefficients of variation from 2.7 to 10.4%.
Spectrophotometric Method for the Microdetermination of Bendiocarb Standard Residues in Water
Authors: Handa Swadesh K 
Published: February 2020

Abstract
A spectrophotometric method has been developed for the microdetermination of bendiocarb in water. The method is based on the reaction of bendiocarb phenol resulting from the hydrolysis of bendiocarb with nitric acid to form a yellow complex with an adsorption maximum at 420 nm. The method is applicable for estimation of residues of bendiocarb in the range of 10-100 μg/5 mL solution.
Bacterial Numbers on Penicylinders Used in Disinfectant Testing: Use of 24 Hour Adjusted Broth Cultures
Authors: Cole Eugene C , Rutala William A 
Published: February 2020

Abstract
The current AOAC use-dilution methods of disinfectant efficacy testing require the use of 48-54 h unadjusted broth cultures of Salmonella choleraesuis, Staphylococcus aureus, and Pseudomonas aeruginosa for the inoculation of stainless steel penicylinders. The use of unadjusted broth cultures contributes to noncomparable numbers of organisms on penicylinders among the test strains due to relative efficacy of bacterial attachment to penicylinders and to bacterial numbers in broth. To achieve comparable numbers of cells on the penicylinders among the 3 test strains, the cell densities of S. aureus and P. aeruginosa in broth culture were visually adjusted. Growth studies were conducted using S. choleraesuis and P. aeruginosa to determine the numbers of cells in broth at timed intervals and the corresponding numbers of cells attaching to the penicylinders. Results showed that the use of the 24 h broth cultures for all 3 test strains, with adjustment of S. aureus and P. aeruginosa broths, contributes to more comparable numbers of organisms attached to the penicylinders used in disinfectant testing.
Ion-Pair Reverse-Phase Liquid Chromatographic Determination Of Amprolium
In Complete Feeds And Premixes
Authors: Kentzer Elzbieta J , Cottingham Layna S , Smallidge Robert L 
Published: February 2020

Abstract
Amprolium is extracted with methanol-water (2 + 1) containing 5mM dioctylsulfosuccinate (DOSS) and lOmM CaCl2. The analyte is separated from coextracted materials by isocratic ion-pair reversephase liquid chromatography, following removal of late-eluting materials on an acid alumina cleanup column, and is detected at 270 nm. The mobile phase contains 4mM DOSS with 0.3% diethylamine and 1% acetic acid in 40% acetonitrile. Linearity is satisfactory over the range of 2.5-50 /xg/mL. Mean recovery, as determined by standard addition to commercial samples, is 100.1%. Accuracy was further tested in studies comparing the LC method to the official AOAC colorimetric method, using commercial samples, and was found to be satisfactory. Studies show that common poultry feed additives, grass meals, and some pelletization aids do not interfere with the analysis; however, when bentonite is present, recovery is decreased. The precision of the method, measured over several experiments on commercial samples, is satisfactory as indicated by coefficients of variation ranging from 1 to 4.5. A ruggedness test resulted in an overall CV of 3.2%, indicating the probable success of the method in a collaborative study.
Simultaneous Determination of Diazinon and Chlorpyrifos Pesticide Formulations
by Liquid Chromatography
Authors: Bushway Rodney J , Perkins L Brian , Joan King M 
Published: February 2020

Abstract
A liquid chromatographic (LC) method has been developed to analyze simultaneously separate formulations of diazinon and chlorpyrifos. Samples of each formulation were mixed in a Polytron mixer with the internal standard butylated hydroxytoluene and were diluted with acetonitrile. An aliquot was injected into an Ultremex LC column. The mobile phase was acetonitrile-water-tetrahydrofuran-glacial acetic acid-monoethanolamine (480 + 230 + 55 + 2 + 0.75); all 3 compounds were monitored at 230 nm. Total analysis time was 11 min. Combinations of 11 different samples of each formulated pesticide were analyzed 9 times for coefficients of variation generally less than 3%. Purity of the diazinon, chlorpyrifos, and butylated hydroxytoluene was checked by using a photodiode array detector in the spectrum and absorbance ratio modes. No interferences were noted at 230 nm.
Analysis of Rotenone in Cube and Derris Root Powders and Formulations by Liquid
Chromatography
Authors: Bushway Rodney J , Yang Angela , AL-Yamany Ali 
Published: February 2020

Abstract
A modified liquid chromatographic (LC) procedure, including an improved extraction, has been developed to analyze rotenone in root powders of derris and cube. The procedure is also applicable to formulations. Samples are sonicated for 5 min in chloroform or a mixed solvent of tetrahydrofuran-acetonitrile-water-glacial acetic acid, followed by liquid chromatography. Rotenone content of 4 lots of root powder samples showed good agreement between the new extraction and the AOAC official extraction; coefficients of variation ranged from 5 to 1.2%. Five formulations were also analyzed and showed good agreement with results for methanol extraction. Coefficients of variation were 4.5% or less. Purity of the rotenone peaks was tested by using a photodiode array detector in the spectrum and UV ratio modes. It is recommended that the new method be tested collaboratively.
Gas Chromatographic Determination of N-Nitrosodialkanolamines in Herbicide Di- or
Trialkanolamine Formulations
Authors: Wigfield Yuk Y , Lacfloix Mario D , Lanouette Monique , Gurprasad Narine P 
Published: February 2020

Abstract
A modified method is presented to determine trace quantities of N-nitrosodiethanolamine (NDE1A) and yV-nitrosodiisopropanolamine (NDiPlA) in the triisopropanolamine (TiPlA) formulation of a mixture of picloram and 2,4-D. Aqueous sample is extracted with dichloromethane to remove organic interferences, and then the aqueous layer is passed sequentially through chloride anion exchange column, hydrogen cation exchange column, and Clin-Elut extraction tube. The final eluate, 10% acetone in ethyl acetate, is concentrated. The isolated nitrosamines are converted to the corresponding trimethylsilyl (TMS) derivatives and determined by gas chromatography (GC) on a DB1 column coupled with a thermal energy analyzer (GC-TEA). Eight samples of commercial TiPlA formulations are analyzed. Maximum detected levels of NDE1A and NDiPlA were 0.6 and 0.9 ppm, respectively, expressed relative to total weight of active ingredients. Analysis of 13 samples of herbicide DEIA formulation using a previously established method and a DB225 column gave NDE1A results of 0.7-6.0 ppm. NDiPlA was not detected in those samples. Results are confirmed by GC-mass spectrometry (GC/MS) with oxygen negative chemical ionization (ONCI) detection. Dectection limits for both nitrosamines are 0.05 or 0.07 ng (0.1 or 0.17 ppm) for GC-TEA detection, depending on the analytical columns used, and 20 pg (0.04 ppm) for GC/MS detection. Recoveries of NDE1A are 87-109% for DEIA formulation spiked at 2.6 and 3.9 ppm and 90-115% for TiPlA formulation spiked at 0.2-0.3 ppm. Similarly, recoveries of NDiPlA are 95.7-100% for the DEIA formulation spiked at 0.24 and 0.48 ppm, and 82-118% for the TiPlA formulation spiked at 0.2-0.3 ppm.