bluuebunny/crossref_metadata_2025_split huggingface dataset:
Karakteristik Kimia Biskuit dari Tepung Ubi Jalar Ungu dan Terigu
Authors: Putri Yerika , Julianti Elisa , Ridwansyah Ridwansyah 
Published: June 2020

Penelitian ini dilakukan untuk mengetahui pengaruh perbandingan tepung ubi jalar ungu dan terigu terhadap karakteristik kimia biskuit. Penelitian ini terdiri dari dua tahap, yaitu pembuatan tepung ubi jalar ungu dan pembuatan biskuit. Penelitian ini menggunakan rancangan acak kelompok (RAL) non faktorial dalam pembuatan biskuit, yaitu perbandingan tepung ubi jalar ungu dan terigu (100:0, 70:30, dan 0:100). Hasil penelitian menunjukkan bahwa biskuit dengan perbandingan tepung ubi jalar ungu dan terigu 70:30 memiliki pengaruh berbeda tidak nyata terhadap kadar air, kadar abu, kadar lemak, total karbohidrat, total flavonoid, serat pangan total, serat pangan larut, serat pangan tidak larut, AKG serat pangan biskuit dengan perbandingan tepung ubi jalar ungu dan terigu 100:0 namun memiliki pengaruh berbeda nyata terhadap kadar protein, kalori, kalori per sajian, dan pemenuhan kecukupan energi hariannya. Hasil penelitian juga menunjukkan bahwa biskuit dengan perbandingan tepung ubi jalar ungu dan terigu 70:30 memiliki pengaruh berbeda tidak nyata terhadap kadar abu, kadar protein, kadar lemak, serat pangan total, serat pangan larut, AKG serat pangan, kalori, kalori per sajian, dan pemenuhan kecukupan energi harian biskuit dengan perbandingan tepung ubi jalar ungu dan terigu 0:100 namun memiliki pengaruh berbeda nyata terhadap kadar air, total karbohidrat, dan serat pangan tidak larutnya.
Kajian Pemanfaatan Limbah Kertas Percetakan untuk Pembuatan Bokasi
Authors: Irfan Irfan , Sulaiman Ismail , Werdana M. Odit 
Published: June 2020

Organical material such as animal dung, husk ash, bran, and sawdust is often used in bocation production. In this study, the paper waste of printing company at Syiah Kuala University was enriched in the raw material of bocation production. This study was aimed to determine the proportion of paper waste that can be added and the duration of fermentation process in order to produce a good bocation. The method used was a factorial Completely Randomized Design (CRD) which consisting of 2 factors. The first factor was the proportion of paper waste (K) with 4 levels: K1 = 15%, K2 = 25%, K3 = 35%, and K4 = 45%. The second factor was the fermentation duration (L) with 3 levels: L1 = 0 day, L2 = 10 days, and L3 = 15 days. Each treatment was repeated twice so that there were 24 experimental units. The analysis included: water content, total microorganisms, temperature, pH, C element, N element, C/N ratio, organoleptic (texture, aroma, color) and plant growth test. The result showed that additional paper waste with a proportion of up to 35% generally has a positive effect on the quality of the location in terms of water content, pH, nitrogen, texture, aroma, color, and plant growth. The longer the fermentation took place (up to 15 days) the better was the quality of the bocation produced, especially regarding C element, N element, C/N ratio, texture, aroma, color and plant growth. There were 3 interactions with the best plant height namely K3L3 (112.5cm), K3L2 (104 cm) and K2L3 (104 cm). The K3L3 bocation (35% paper waste proportion, 15 days fermentation) was better than the other two interactions in term of highest water content, N, and color value, and the lowest C/N ratio.
Comparación de la modificación en algunas pruebas de coagulación por el uso de tres anticonceptivos orales
Authors: Castillo José D. , Mendoza César 
Published: June 2020

Se estudian las modificaciones de algunas pruebas de coagulación sanguínea en mujeres que reciben anovulatorios. 284 son seguidas durante un año. Los resultados promedio se encuentran dentro de cifras normales. De los tres grupos en estudio uno mostró ligero aumento de la coagulabilidad sanguínea.En pacientes bien seleccionadas nuestra experiencia permite afirmar que no hubo accidentes trombóticos.
Menopausia
Authors: Cáceres Alvarez Eduardo 
Published: June 2020

La mujer es el único animal sobre la tierra agobiada por la menopausia ya que todos los animales pueden reproducirse prácticamente hasta el ultimo día de su vida. Sin embargo, esta desigualdad tan peculiar no existió siempre. Hasta el año 1 de nuestra era o poco después, la expectativa de vida era de 33 años y la mujer, como todos los otros animales de diferentes especies, moría con sus funciones ováricas en pleno apogeo.
"Determinación de la madurez fetal y neonatal en gestantes de alto riesgo y análisis citoquimico del liquido amniótico"
Authors: Júbiz H Alfonso , Zapata L. Beatriz , Mejía William , Restrepo S. Jorge , Posada Alvaro , Laguado Ivonne 
Published: June 2020

Es de gran interés para el obstetra y el pediatra conocer la edad gestacional y determinar la madurez fetal especialmente en aquellos embarazos con patología que inciden en el desarrollo del producto de la concepción en las cuales la terminación electiva es deseada.
La Membrana Intrauterina (Un Dispositivo Intrauterino Experimental) en el Post-aborto Precoz
Authors: Quan Angel , Edelman David , Ventura Teresa , De Badia Delfina 
Published: June 2020

La eficacia clínica y anticonceptiva de la inserción de la membrana intra-uterina (MIU) después del tratamiento de un aborto, inevitable o incompleto, fue estudiada en 127 casos. A pesar que la inserción del MIU parece ser un procedimiento seguro sin mayores complicaciones, este dispositivo está asociado con altas tasas de embarazo y retiro por metrorragia y/o dolor y no es adecuado para ser usado después de un aborto incompleto o inevitable. Las tasas acumulativas por tipo de terminación por 100 usuarios a los seis meses de uso fueron de 4.3 por embarazo, 3.9 por expulsiones, y 14.4 por retiros por metrorragia y/o dolor.
Role of stilbens in mechanisms hepatoprotective properties of polyphenols Maackia amurensis
Authors: Chuchalin V. S. , Ratkin A. V. , Ratkin Ye. V. , Frolov V. N. , Ivanov V. V. , Fedoreyev S. A. , Bulgakov V. P. , Zorcaltsev S. S. 
Published: June 2020

For finding-out of a role monomer and dimer srilbens in realization hepatoprotective properties of polyphenols maakia amurensis activity of polyphenolic complexes from wood (Maksar), an extract of cellular culture maakia amurensis, and also monomer and dimer srilbens, allocated of a substance Maksar was investigated.Therapeutic efficiency of researched objects was estimated on their influence on survival rate of animals, morphological and biochemical parameters of a liver and wheys of blood of rats with an experimental СCl4-hepatites. It was established, that hepatoprotective influence of Maksar and an extract of cellular culture maakia amurensis is caused by presence of the sums isoflavonoids in their structure. Monomer and dimer srilbens do not show therapeutic activity at an experimental toxic hepatites.
Use the product mares milk in rehabilitation of patients with ischemic heart disease
Authors: Gilmutdinova L. T. , Yanturina N. H. , Kudayarova R. R. , Kamaletdinov S. H. , Yamaletdinov K. S. , Ahmadullin R. V. , Gabdelhakova L. A. 
Published: June 2020

Studied antioxidant and therapeutic efficacy of the product fermented mares milk — kumis in the complex sanatorium treatment of 134 patients with stable angina pectoris I, II functional class (FC). Made kumis derived from fermented mares milk, Lactobacterium bulgaricum and yeasts such as Torula.Kumis contributed to the activation of antioxidant enzymes against inhibition of peroxidation processes of metabolism and lipid-lowering effect. The developed approach is an effective method of complex of regenerative therapy in patients with chronic coronary heart disease.
Peculiarities of people mortality in the Tomsk Region and main ways of its decrease
Authors: Kladov S. Yu. , Konobeyevskaya I. N. , Karpov R. S. 
Published: June 2020

Peculiarities in the structure of mortality of people living in the Tomsk Region have been revealed, and main ways to decrease the mortality have been determined. In 2002 the death rate in the Tomsk Region was 14.3 per 1000 people, which is lower than the average Russian death rate (16.3). The analysis of death causes has shown that the most frequent causes are diseases of the blood system, while the second and third places are occupied by the death from neoplasm, as well as from accidents, poisoning, and traumas.The health factor should become of the high priority in all spheres of human activity. Any measure should favor the formation of the healthy life style and everybody’s personal responsibility for the health. It is worth developing the interbranch demographic concept of the Tomsk Region as an integral part of the concept of the enhancement of life quality for people living in the Tomsk Region.
The experience of oxalate nephrolithiasis therapy by sodium pyrophosphate in experiment
Authors: Zharikov A. Yu. , Zverev Ya. F. , Lampatov V. V. , Bryukhanov V. M. , Azarova O. V. , Talalayeva O. S. , Kudinov A. V. , Motin Yu. G. 
Published: June 2020

The aim of the investigation was studying sodium pyrophosphate’s effect on experimental oxalate nephrolithiasis.Experimental nephrolithiasis modeling by using of 1% ethylenglycole’s solution as a drink for rats during 6 weeks. First group was control. In the second group since the third week was being administrated sodium pyrophosphate in dose 2 g/kg. Was detecting parameters of kidney’s function, markers enzymes activity, was carried out morphological researches.It was concluded that sodium pyrophosphate’s therapy reduce experimental oxalate nephrolithiasis.
Liver injury under chronic viral hepatitis C against the background of opiomania: morphological characters
Authors: Beloborodova Ye. V. , Podgornova D. V. , Purlik I. L. , Beloborodova E. I. , Petrova L. A. , Volchanovskaya M. M. , Shkorlupa S. G. , Goncharova I. A. , Akbasheva O. Ye. 
Published: June 2020

To ascertain the severity of opium-induced liver injury for chronic viral hepatitis C (HCV) patients with detection of morphological characters of hepatocyte impact by opiates.Needle biopsy of liver and the light microscopy of biopsy material were made both for isolated HCV and HCV+opiomania patients.Liver injury (hepatitis activity, fibrosis stage) for HCV patients against the background of opiomania does not differ from the case of isolated HCV. Use of alcohol by opium addicts even in very small doses (10—15 g per day) cause the development of significantly more severe liver injury. Fibrosis of central vein was found significantly more often for HCV against the background of opiomania.Fibrosis of central vein is a differential-diagnostic criterion of being opiates as an etiological factor of liver injury. Opiates as an isolated toxic factor does not cause severe liver injury for HCV patients unlike the use of alcohol even in small doses.
Effect of polyphenolic complexes wood and cellular culture Maackia amurensis on the MR тomography performance of a liver
Authors: Chuchalin V. S. , Ratkin A. V. , Ratkin Ye. V. , Fedoreyev S. A. , Bulgakov V. P. 
Published: June 2020

Comparative evaluation of hepatoprotective properties of polyphenolic fraction from wood (Maksar) and a polyphenolic complex of cell culture of Maakia amurensis.Therapeutic efficacy of the objects was assessed by their effect on the MR tomographic performance of the liver of rats with experimental СCl4-hepatitis. Hepatoprotective activity of polyphenol complex cell culture Maakia amurensis is not inferior to the original effect of the drug Maksar.
RESPIRATORY FUNCTION RECOVERY OF THE POSTSURGICAL PATIENTS BY MEANS OF THE BIOFEEDBACK OF THE CARBON DIOXIDE CONCENTRATION IN EXHALED AIR AND RESPIRATORY RATE
Authors: Brazovskaya N. G. , Melekhin Ye. V. , Svetlik M. V. , Brazovsky K. S. , Vusik A. N. 
Published: June 2020

The methodical, technical and software realization of the biofeedback of expiration parameters are described. The biofeedback training method based on the breath frequency and CO2 concentration regulation is proposed. Preliminary study was conducted in the group of patients after abdominal surgical. It has been shown that the patients master their skills of CO2 concentration self-regulation. Using biofeedback for the postsurgical rehabilitation facilitates the rapid recovery of the expiration parameters.
ATYPICAL FORMS OF MULTIPLE SCLEROSIS IN THE TOMSK REGION
Authors: Alifirova V. M. , Titova M. A. , Terskikh E. V. , Musina N. F. 
Published: June 2020

The study involved 280 patients aged 10 to 70 years old with a valid diagnosis of multiple sclerosis according to the McDonald criteria. There are 6 (2.1%) patients had the first manifestation of disease overthe age of 45, 18 (6.4%) – 20 years earlier. In 7 (2.5%) of patients diagnosed with malignant progressof the MS, in 30 (10.7%) – soft progress.
STUDY CARDIOTOXIC PROPERTIES OF NATIVE PEAT HUMIC ACIDS
Authors: Belousov M. V. , Akhmedzhanov R. R. , Zykova M. V. , Maslov L. N. , Guriyev A. M. , Yusubov M. S. 
Published: June 2020

The earlier pathomorphological studies of toxic properties of peat humic acids (PHAs) at intraperitoneal injection revealed that one of the causes of lethality is the direct cardiotoxic action of PHAs. For the further study of the mechanism of cardiotoxic action, electrocardiogram was recorded and ventricular fibrillation threshold was determined in male rats after intraperitoneal injection of humic acids in knowingly lethal dose – 480 mg/kg bwt. A single intraperitoneal injection of PHA to rats in knowingly lethal dose caused a significant decrease of the ventricular fibrillation threshold in comparison with intact animals. It was found that the PHA injection exerted no significant effect on the heart rate in rats and change of the PQ, QT, and QTc intervals. At the same time, the significant shortening of the QRS complex in comparison with intact animals was observed. Judging from the results obtained, the single injection of humic acids in the lethal dose induced a decrease in the electrical stability of heart, as evidenced by the drop of the ventricular fibrillation threshold. This decrease of the electrical stability of heart can be a cause of sudden cardiac death of trial rats. Disorder of the heart electrical stability is likely connected with the ionophoric action of humic acids and change of electrophysiological properties of cell membranes.
CARDIOVASCULAR MAGNETIC RESONANCE WITH CONTRAST AGENT: PROGNOSTIC ROLE IN DETERMINING ARRHYTMOGENIC FOCUS
Authors: Bogunetsky A. A. , Ussov V. Yu. , Babokin V. Yu. 
Published: June 2020

In order to evaluate the possibilities of MRI in detection of proarrhytmogenic areas of myocardium we did compare directly and quantitatively the local myocardial uptake of paramagnetics to the results of electrophysiologic study of myocardium in twenty-two patients with recent transmural myocardial infarction and frequent ventricular extrasystoles verified by ECG studies.Topic quantitative study of myocardial electric potential has been carried out using Carto XP system (by Biosense Webster).By analysis of the images the measurement of Index of transmurality (IT) for the contrast uptake was calculated as ratio of thickness of paramagnetic uptake to overall thickness of myocardium in a specific segment.The the electrophysiologic and MRI data were analyzed topically as segment vs segment and the significant tendency was revealed with simultaneous grow of pro-arrhythmogenic activity and value of IT. In other words, as bigger the IT increases, as arrhythmogenic the lectrical activity becomes. The best border value of IT that provided separation of electrically normal segments from proarrhythmogenic ones was the IT = 0.3.Therefore we conclude the contrast-enhanced MRI of myocardium deliver additional information on risk of arrhythmias, not only the detection of myocardial damage itself.
ROLE OF NEUROSPECIFIC PROTEINS IN THE DEVELOPMENT OF COGNITIVE DYSFUNCTION IN PATIENTS WITH TYPE 1 DIABETES
Authors: Novosyolova M. V. , Samoilova Yu. G. , Zhukova N. G. , Latypova A. V. 
Published: June 2020

Type 1 (type 1 DM) diabetes mellitus is one of the common chronic metabolic diseases, which currently is a significant problem due to disability at a young age and reduce life expectancy. Despite the fact that type 1 diabetes accounts for only 10% of all patients with diabetes, it occurs particularly hard, with a tendency to progression. One of the targets of type 1 diabetes is the central nervous system with the further formation of cognitive dysfunction in young age leads to diminished quality of life. Cognitive deficits may be the result not only of structural lesions of the brain, but it may be due to the development of metabolic disorders. In the case of timely diagnosis and treatment of cognitive impairment associated with metabolic changes that can partially or completely regress. The aim of this study was to identify biomarkers of the brain damage in young patients with type 1 diabetes. The study involved 58 patients with type 1 diabetes, the control group comprised 29 healthy controls. The complex included a neuropsychological examination which was used for testing the Montreal scale (MoCA test) rapid screening of cognitive impairment, assessment of quality of life using a common questionnaire Medical Outcomes Study Short Form (MOS SF-36) and the specific audit – dependent quality of life (ADDQoL). To evaluateearly markersin the developmentof cognitive dysfunctionwere identifiedneurospecific proteins – S100 protein and glial fibrillary acidic protein (GFAP), myelin basic protein (MBP). Found an increased level of neurospecific protein that was correlated with parameters of carbohydrate metabolism, poor quality of life and severe cognitive deficiency (MoCA test lower than 26 points).
BILE LITHOGENICITY IN PATIENTS WITH TYPE 2 DIABETES AND ITS CORRECTION
Authors: Pavlenko O. A. , Babich Ye. N. 
Published: June 2020

We conducted a study to assess the bile lithogenicity in patients with type 2 diabetes mellitus (DM). We have found increased levels of cholesterol both in the gallbladder and hepatic bile. The study showed a decrease of cholatocholesterol coefficient (HHC), increase of lithogenic index Thomas–Hofmann and Rubens in all patients with type 2 diabetes, particularly in the gallbladder bile, indicating the colloidal destabilization of bile and an increased tendency to stone formation. Especially pronounced lithogenicity bile in patients with type 2 diabetes was associated with age in patients over 40 years of age and concomitant overweight or obese (BMI > 27 kg/m2). After a course of ursodeoxycholic acid (UDCA) at a dose of 15 mg/kg of body weight per day for 2.5–3 months was reduced lithogenicity gallbladder bile in patients with type 2 diabetes mellitus when the duration of disease was up to 5 years in 1.3 times, more than 5 years – in 1.5 times, more than 10 years – 1.7 times according to the index Thomas–Hofmann and Rubens.
SOURCES OF THE ELECTROPHYSIOLOGY AND ELECTROCARDIOGRAPHY
Authors: Tetenev F. F. , Stepanischeva A. N. 
Published: June 2020

The basic stages of development of electro-physiology and electrocardiography, 17 portraits and years of life of scientists, developing the fundamental aspects of electro-physiology, and also applied direction clinical electrocardiography, are presented in the article. By the most large scientists, developing fundamental direction in electro-physiology were P. Arrhenius, V.Yu. Chagovec, Yu. Bernshteyn, A. Khodzhkin and E. Khaksli. In development of the applied direction in electrocardiography the role is great of V. Eyntkhoven, A.V. Samoilov and N. Holter. In period of formation of formation of electrophysiology, electrocardiography and at present scientists in ours country preferently working in applied direction.
POLYMORPHISM OF GENES OF IMMUNOSUPRESSIVE CYTOKINE IL-10 AND TGF-β AT TUBERCULOSIS INFECTION
Authors: Churina Ye. G. , Urazova O. I. , Novitsky V. V. , Filinyuk O. V. 
Published: June 2020

The aim of the work was the study of connection of allelic polymorphism of IL10 and TGFВgenes with changes in the basal and BCG-induced production of immunosuppressive cytokines IL-10 and TGF-β by mononuclear leukocytes in vitro in patients with the first diagnosed pulmonary tuberculosis (TB), depending on the clinical form of the disease. The evaluation of the cytokines production was conducted by measuring its concentration in culture supernatants by ELISA. The allele-specific amplification of specific stretches of the genome was used for the study of polymorphic genes of cytokines. The DNA and supernatants of culture suspensions of blood mononuclear leucocytes in healthy volunteers and patients with TB were the material of the research. It was shown in the research conducted that the basal and BCG-induced over-production of IL-10 in vitro occurs in patients with TB, regardless of the genotype of the locus of C-592AIL10 gene. In addition, genotype AA of polymorphism of IL10gene in patients with infiltrative and disseminated TB is associated with the maximum production of IL-10 in vitroand genotype CC – with the minimum production of this cytokine in vitro. Analysis of the production of TGF-β in vitro in patients with TB showed its increase only in case of carriage of allele T (C-509T) of TGFB gene. In patients with disseminated TB and homosygotic genotype TT the increase in both basal and BCG-induced production of TGF-β was determined, and in patients with infiltrative TB – only after induction of cells by BCG-antigen.Thus, the over-production of cytokines with inhibiting activity in patients with TB is genetically determined and promotes the formation of suppressive mode of immune-regulation. The increase in the secretion of cytokines IL-10 and TGF-β in vitro in patients with TB are associated with carriage of allele A and genotype AA (C-592A) of IL10gene and allele T and genotype TT (C-509T) of TGFB gene.
DEVELOPMENT OF OPTIMAL EXPERIMENTAL THERAPEUTIC REGIMENS ADMINISTRATION OF IMMOBILIZED INTERFERON α-2b
Authors: Shitikova O. G. , Sherstoboev E. Yu. , Masnaya N. V. , Danilets M. G. , Trofimova E. S. , Ligacheva A. A. , Madonov P. G. , Kinsht D. N. , Ershov K. I. , Shilova M. A. 
Published: June 2020

The development of optimal experimental therapeutic schemes of immobilized interferon α-2b (production of JSC «Siberian Center for Pharmacology and Biotechnology», Novosibirsk) administration was conducted in the frame of the common program of pre-clinical study. The drug being studied was administered intragastrically for 3, 5 and 7 days in the therapeutic dose (1.8 × 105 IU/kg). Experimental evaluation of immunotropic properties of immobilized interferon α-2b was carried out at in vivoexperiments in outbred CD1 male mice with using of following tests: the study of drug effect on the phagocytic activity of peritoneal leukocytes (the relative number of phagocytes and the number of bacteria which were assimilated by phagocytes were assessed); the study of drug effect on the humoral immune response (the total number of splenocytes, the relative and absolute number of antibody-forming cells and their functional activity were determined); estimation of drug effect on the cellular immune response with the using of delayed-type hypersensitivity test induced by sheep red blood cells. Based on these data we concluded that course administration of immobilized interferon α-2b in the therapeutic dose for 5 days increased phagocytosis of neutrophils and humoral immune response most effectively. Cell-mediated immune response was significantly increased after 7-fold administration of studied drug.