bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal Sevoflurane Exposure Affects Differentiation of Hippocampal Neural Stem Cells by Regulating microRNA-410-3p and ATN1
Authors: ZHANG YI , WU ZIYI , LI XINGYUE , WAN YUXIAO , ZHANG YINONG , ZHAO PING 
Published: June 2020

Abstract
BackgroundCurrently, numerous animal studies have shown that exposure to commonly used general anesthetics during pregnancy may cause neurocognitive impairment in the offspring. Reportedly, exposure to sevoflurane during mid-trimester of pregnancy can inhibit proliferation of neural stem cells (NSCs) and lead to early apoptosis. Whether exposure to sevoflurane during pregnancy affects the differentiation of NSCs remains unclear. MethodsIn the present study, pregnant rats were exposed to 3% sevoflurane once for 2 h on gestational day 14 (G14) or 3 times for 2 h on G13, G14, and G15. Next, the differentiation of NSCs was measured using neuron marker β-tubulin III and astrocyte marker glial fibrillary acidic protein (GFAP) in fetal brain tissues 24 h and 72 h after anesthesia and in hippocampus on postnatal day 28. The same procedures were performed on primary cultured rat NSCs to explore the mechanism. ResultsThe results showed that during mid-trimester, multiple exposure to sevoflurane can cause premature differentiation of NSCs in developing brains of offspring and lead to long-term neuron reduction and astrocyte proliferation in hippocampus. The data from the present study indicated that repeated exposure to sevoflurane downregulated ATN1 expression and caused early differentiation of NSCs. Overexpression of ATN1 via lentivirus transfection attenuated the influence of sevoflurane. Using dual luciferase assay, ATN1 was found to be a target gene of microRNA‐410-3p (miR‐410-3p). MiR-410-3p suppression via lentivirus transfection recovered the ATN1 expression and differentiation of NSCs.ConclusionsThe results from the present study demonstrated that repeated exposure to sevoflurane leads to early differentiation of NSCs and long-term effects via the miR-410-3p/ATN1 pathway.
Sociodemographic profile, clinical characteristics, anxiety, and depression of 74 patients infected with COVID-19: first report from Bangladesh
Authors: Hasan Mohammad Jahid , Khan Md. Abdullah Saeed , Rahman Monjur , Islam Md. Shahnoor , Debnath Sourav , Fardous  , Amin Professor Dr. Mohammad Robed 
Published: June 2020

Abstract
Background: The pandemic of Corona Virus Disease 2019 (COVID-19) has cost a large number of lives and is causing substantial mental stress among people. We conducted a study to identify the sociodemographic and clinical characteristics and prevalence of anxiety and depression among confirmed COVID-19 cases in Bangladesh.Methods: An online cross-sectional survey using a preformed questionnaire adapted in Google form was conducted for data collection. The form was shared along with a brief introduction and rationale via Facebook, Twitter, Facebook Messenger, Viber, and What’s App. Formal ethical clearance was taken from the Biomedical Research Foundation, Bangladesh. Informed consent was ensured before participation.Results: Seventy-four patients with COVID-19 who had an average age of 42.59±14.43 years with male predominance (77%) were included. A total of 29.7% were doing health-care related jobs, and 14.9% lost their jobs due to COVID-19. Patients had a median income of BDT 30000. Of all, 87.8% of patients were symptomatic and presented with fever (77%), cough (58.8%), breathlessness (24.3%), myalgia (24.3%), sore throat (21.6%), fatigue (17.6%), nausea and/or vomiting (12.2%), headache (12.2%), runny nose (9.5%), chest pain (9.5%), diarrhea (8.1%), ARDS (2.7%), stuffy nose (2.7%), conjunctivitis (1.4%) and oral ulcer (1.4%). Overall, the prevalence of anxiety and depression was 60% and 52.9%, respectively. Among the participants, 11.4% had only anxiety, 4.3% had only depression and 48.6% had both.Conclusion: Patients were mostly middle aged, male and healthy workers. Typical presentations were fever and cough. Nearly two-thirds of the patients had either or both anxiety and depression.
Random forest predictive model development with uncertainty analysis capability for the estimation of evapotranspiration in an arid oasis region
Authors: Wu Min , Feng Qi , Wen Xiaohu , Deo Ravinesh C. , Yin Zhenliang , Yang Linshan , Sheng Danrui 
Published: June 2020

Abstract
The study evaluates the potential utility of the random forest (RF) predictive model used to simulate daily reference evapotranspiration (ET0) in two stations located in the arid oasis area of northwestern China. To construct an accurate RF-based predictive model, ET0 is estimated by an appropriate combination of model inputs comprising maximum air temperature (Tmax), minimum air temperature (Tmin), sunshine durations (Sun), wind speed (U2), and relative humidity (Rh). The output of RF models are tested by ET0 calculated using Penman–Monteith FAO 56 (PMF-56) equation. Results showed that the RF model was considered as a better way to predict ET0 for the arid oasis area with limited data. Besides, Rh was the most influential factor on the behavior of ET0, except for air temperature in the proposed arid area. Moreover, the uncertainty analysis with a Monte Carlo method was carried out to verify the reliability of the results, and it was concluded that RF model had a lower uncertainty and can be used successfully in simulating ET0. The proposed study shows RF as a sound modeling approach for the prediction of ET0 in the arid areas where reliable weather data sets are available, but relatively limited.
Does community-wide water chlorination reduce hepatitis E virus infections during an outbreak? A geospatial analysis of data from an outbreak in Am Timan, Chad (2016–2017)
Authors: Lenglet Annick , Ehlkes Lutz , Taylor Dawn , Fesselet Jean-Francois , Nassariman Jean Noel , Ahamat Abdelkhadir , Chen Alexandra , Noh Idriss , Moustapha Abakar , Spina Alexander 
Published: June 2020

Abstract
Hepatitis E Virus (HEV) genotype 1 and 2 infect an estimated 20 million people each year, via the faecal-oral transmission route. An urban outbreak of HEV occurred in Am Timan, Chad, between September 2016 and April 2017. As part of the outbreak response, Médecins Sans Frontières and the Ministry of Health implemented water and hygiene interventions, including the chlorination of town water sources. We aimed to understand whether these water treatment activities had any impact on the number of HEV infections, using geospatial analysis of epidemiological and water treatment monitoring data. By conducting cluster analysis we investigated whether there were areas of particularly high and low infection risk during the outbreak and explored the reasons for this. We observed two high-risk spatial clusters of suspected cases and one high-risk cluster of confirmed cases. Our main finding was that confirmed HEV cases had a higher median number of days of exposure to unsafe water compared to suspected and non-confirmed cases (Kruskal-Wallis Chi Square: 15.5; p &lt; 0.001). Our study confirms the mixed, but shifting, transmission routes during this outbreak. It also highlights the spatial and temporal analytical methods, which can be employed in future outbreaks to improve understanding of HEV transmission.
Multi-objective optimal allocation of water resources based on ‘three red lines’ in Qinzhou, China
Authors: Guan Haopeng , Chen Lihua , Huang Shuping , Yan Cheng , Wang Yan 
Published: June 2020

Abstract
Water shortages and pollution emerge because of anthropogenic demands. Since 2011, ‘China's Most Stringent Water Resources Management’ (CMSWRM) has been comprehensively enacted in the country. This paper presents the characteristics of the ‘three red lines’ (TRL) and a multi-objective optimal allocation model based on the TRL constraint, considering the benefits for society, the economy, and the environment. This model had been applied to the reasonable allocation of water supply and demand in Qinzhou for the planning years of 2020 and 2030. Two water resource allocation scenarios for these years were configured by setting different chemical oxygen demand (COD) concentrations for wastewater discharge in the municipal, secondary, tertiary, and agricultural sectors. The gamultiobj function based on the NSGA-II algorithm was used to solve the model in MATLAB. The results indicate that if COD concentrations in each sector are not reduced, then restrictions on domestic water sources will be necessary, both in 2020 and 2030. The two water resource allocation scenarios in 2020 and 2030 can provide a reference for decision-makers in Qinzhou to implement CMSWRM.
Assessment of medium and small river health based on macroinvertebrates habitat suitability curves: a case study in a tributary of Yangtze River, China
Authors: Su Yifan , Li Weiming , Liu Liu , Li Jinjing , Sun Xuyang , Hu Wei 
Published: June 2020

Abstract
The health of medium and small river ecosystems is threatened by increasing hydropower development and human activities. How to properly diagnose rivers has become a global concern. As a well-accepted theory, the aquatic organism density can be an indicator of river health. A new river health assessment method based on macroinvertebrates habitat suitability curves (M-HSC) was proposed. In this study, the health of Qiaobian River (QBR), a tributary of Yangtze River, China was evaluated by investigating the distribution of macroinvertebrates, chemical and physical parameters during winter 2018 (low flow season) and summer 2019 (high flow season). Based on habitat suitability of dominant macroinvertebrates, the key habitat factors were screened by canonical correspondence analysis (CCA) and Pearson correlation analysis. Suitability curves were determined by Generalized Additive Model (GAM). Ecosystem health comprehensive index method was used to evaluate the health status. The results show most suitable conditions for Corbicula fluminea containing chemical oxygen demand (CODMn) of 1.48 mg L−1, total nitrogen (TN) of 0.27 mg L−1, dissolved oxygen (DO) of 11.17 mg L−1, pH of 8.42, turbidity of 1.76 NTU, and water depth (Dep) of 0.35 m. The health status of QBR is spatially heterogeneous with the apparently better upstream than the downstream. In general, 25, 12.5, 12.5% of the samples were classified as nature, health and sub-health status, respectively and the rest 50% were lower than sub-health. The results are consistent with the environmental quality standards for surface water in China (GB3838-2002), suggesting the applicability of macroinvertebrates habitat suitability for evaluating river health. By minimizing the temporal and spatial limitations of comprehensive evaluation method and indicator species method, this study, for the first time, used macroinvertebrates habitat suitability curves to assess the health of medium and small rivers. The study will provide new insights for future river health assessments.
Efficient degradation of naproxen by persulfate activated with zero-valent iron: performance, kinetic and degradation pathways
Authors: Dong Shuyu , Zhai Xiaoxue , Pi Ruobing , Wei Jinbao , Wang Yunpeng , Sun Xuhui 
Published: June 2020

Abstract
Degradation of naproxen (NAP) by persulfate (PS) activated with zero-valent iron (ZVI) was investigated in our study. The NAP in aqueous solution was degraded effectively by the ZVI/PS system and the degradation exhibited a pseudo-first-order kinetics pattern. Both sulfate radical (SO4•−) and hydroxyl radical (HO•) participate in the NAP degradation. The second-order rate constants for NAP reacting with SO4•− and HO• were (5.64 ± 0.73) × 109 M−1 s−1 and (9.05 ± 0.51) × 109 M−1 s−1, respectively. Influence of key parameters (initial pH, PS dosage, ZVI dosage, and NAP dosage) on NAP degradation were evaluated systematically. Based on the detected intermediates, the pathways of NAP degradation in ZVI/PS system was proposed. It was found that the presence of ammonia accelerated the corrosion of ZVI and thus promoted the release of Fe2+, which induced the increased generation of sulfate radicals from PS and promoted the degradation of NAP. Compared to its counterpart without ammonia, the degradation rates of NAP by ZVI/PS were increased to 3.6–17.5 folds and 1.2–2.2 folds under pH 7 and pH 9, respectively.
Dapsone is not a Pharmacodynamic Lead Compound for its Aryl Derivatives
Authors: Scior Thomas , Abdallah Hassan H. , Salvador-Atonal Kenia , Laufer Stefan 
Published: June 2020

Background:
The relatedness between the linear equations of thermodynamics and
QSAR was studied thanks to the recently elucidated crystal structure complexes between sulfonamide
pterin conjugates and dihydropteroate synthase (DHPS) together with a published set of thirty-
six synthetic dapsone derivatives with their reported entropy-driven activity data. Only a few
congeners were slightly better than dapsone.

Objective :
Our study aimed at demonstrating the applicability of thermodynamic QSAR and to
shed light on the mechanistic aspects of sulfone binding to DHPS.

Methods:
To this end ligand docking to DHPS, quantum mechanical properties, 2D- and 3D-QSAR
as well as Principle Component Analysis (PCA) were carried out.

Results:
The short aryl substituents of the docked pterin-sulfa conjugates were outward oriented into
the solvent space without interacting with target residues which explains why binding enthalpy
(ΔH) did not correlate with potency. PCA revealed how chemically informative descriptors are
evenly loaded on the first three PCs (interpreted as ΔG, ΔH and ΔS), while chemically cryptic ones
reflected higher dimensional (complex) loadings.

Conclusions:
It is safe to utter that synthesis efforts to introduce short side chains for aryl derivatization
of the dapsone scaffold have failed in the past. On theoretical grounds we provide computed
evidence why dapsone is not a pharmacodynamic lead for drug profiling because enthalpic terms do
not change significantly at the moment of ligand binding to target.
Job Search Duration and Business Preparation Duration: An Empirical Study of Micro Data in Indonesia with Cox Regression
Authors: Safitri Hendri Cahyo Dwi , Afiatno Bambang Eko 
Published: June 2020

Abstract: This study aims to analyze the difference in job search duration and business preparation duration based on education level, training, job experience, marital status, age, and sex. The total unit of analysis used in this study is 51,112 individuals sourced from National Labor Force Survey (Sakernas) conducted in August 2017. This study applies the Survival Analysis with Cox Regression. The survival rate results show that unemployed people who prepare a business will get a job faster than their counterparts who are still looking for a job. Cox regression testing shows that education, training, marital status, and age have significantly affected job search duration in Indonesia. Meanwhile, education, training, and marital status have significantly influenced the period of business preparation in Indonesia. Keywords: unemployment, job search duration, business preparation duration, cox regression, survival analysis Lama Mencari Kerja dan Lama Mempersiapkan Usaha: Studi Empiris Data Mikro di Indonesia Abstrak: Penelitian ini bertujuan untuk menganalisis perbedaan lama mencari kerja dan lama mempersiapkan usaha dilihat dari tingkat pendidikan, pelatihan, pengalaman kerja, status perkawinan, umur, serta jenis kelamin. Total unit analisis yang digunakan sebanyak 51.112 individu yang bersumber dari data Survei Angkatan Kerja Nasional (Sakernas) Agustus 2017. Metode analisis yang digunakan adalah Survival Analysis dengan Cox Regression. Hasil survival rate menunjukkan bahwa pengangguran yang mempersiapkan usaha akan lebih cepat memperoleh pekerjaan dibandingkan dengan pengangguran yang mencari pekerjaan. Pengujian dengan cox regression menunjukkan bahwa pendidikan, pelatihan, status perkawinan, dan umur berpengaruh signifikan terhadap lama mencari pekerjaan di Indonesia. Sedangkan pendidikan, pelatihan, dan status perkawinan berpengaruh signifikan terhadap lama mempersiapkan usaha di Indonesia. Kata kunci: pengangguran, lama mencari kerja, lama mempersiapkan usaha, regresi cox, analisis survival
A Digital Companion, the Emma App, for Ecological Momentary Assessment and Prevention of Suicide: Quantitative Case Series Study
Authors: Morgiève Margot , Genty Catherine , Azé Jérôme , Dubois Jonathan , Leboyer Marion , Vaiva Guillaume , Berrouiguet Sofian , Courtet Philippe 
Published: June 2020

Background
Many suicide risk factors have been identified, but traditional clinical methods do not allow for the accurate prediction of suicide behaviors. To face this challenge, emma, an app for ecological momentary assessment (EMA), ecological momentary intervention (EMI), and prediction of suicide risk in high-risk patients, was developed.

Objective
The aim of this case report study was to describe how subjects at high risk of suicide use the emma app in real-world conditions.

Methods
The Ecological Mental Momentary Assessment (EMMA) study is an ongoing, longitudinal, interventional, multicenter trial in which patients at high risk for suicide are recruited to test emma, an app designed to be used as a self-help tool for suicidal crisis management. Participants undergo clinical assessment at months 0, 1, 3, and 6 after inclusion, mainly to assess and characterize the presence of mental disorders and suicidal thoughts and behaviors. Patient recruitment is still ongoing. Some data from the first 14 participants who already completed the 6-month follow-up were selected for this case report study, which evaluated the following: (1) data collected by emma (ie, responses to EMAs), (2) metadata on emma use, (3) clinical data, and (4) qualitative assessment of the participants' experiences.

Results
EMA completion rates were extremely heterogeneous with a sharp decrease over time. The completion rates of the weekly EMAs (25%-87%) were higher than those of the daily EMAs (0%-53%). Most patients (10/14, 71%) answered the EMA questionnaires spontaneously. Similarly, the use of the Safety Plan Modules was very heterogeneous (2-75 times). Specifically, 11 patients out of 14 (79%) used the Call Module (1-29 times), which was designed by our team to help them get in touch with health care professionals and/or relatives during a crisis. The diversity of patient profiles and use of the EMA and EMI modules proposed by emma were highlighted by three case reports.

Conclusions
These preliminary results indicate that patients have different clinical and digital profiles and needs that require a highly scalable, interactive, and customizable app. They also suggest that it is possible and acceptable to collect longitudinal, fine-grained, contextualized data (ie, EMA) and to offer personalized intervention (ie, EMI) in real time to people at high risk of suicide. To become a complementary tool for suicide prevention, emma should be integrated into existing emergency procedures.

Trial Registration
ClinicalTrials.gov NCT03410381; https://clinicaltrials.gov/ct2/show/NCT03410381
Web-Based Interventions for Dietary Behavior in Adults With Type 2 Diabetes: Systematic Review of Randomized Controlled Trials
Authors: Dening Jedha , Islam Sheikh Mohammed Shariful , George Elena , Maddison Ralph 
Published: June 2020

Background
Type 2 diabetes mellitus (T2DM) is among the most prevalent noncommunicable health conditions worldwide, affecting over 500 million people globally. Diet is a key aspect of T2DM management with dietary modification shown to elicit clinically meaningful outcomes such as improved glycemic control, and reductions in weight and cardiovascular disease risk factors. Web-based interventions provide a potentially convenient and accessible method for delivering dietary education, but its effects on dietary behavior in people with T2DM are unknown.

Objective
The objective of this review was to determine the effectiveness of web-based interventions on dietary behavior change and glycemic control in people with T2DM.

Methods
Per PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, systematic literature searches were performed using Medline, Embase, The Cochrane Library, and CINAHL to retrieve papers from January 2013 to May 2019. Randomized controlled trials of web-based interventions in adults with T2DM with reported dietary assessment were included. Population and intervention characteristics, dietary guidelines and assessments, and significant clinical outcomes were extracted. Differences between groups and within groups were assessed for dietary behavior and clinical outcomes.

Results
There were 714 records screened, and five studies comprising 1056 adults were included. Studies measured dietary changes by assessing overall diet quality, changes in specific dietary components, or dietary knowledge scores. Significant improvements in dietary behavior were reported in four out of the five studies, representing healthier food choices, improvements in eating habits, reductions in carbohydrates, added sugar, sodium, saturated fat and overall fat intake, and/or increases in dietary knowledge. Three studies found significant mean reductions for hemoglobin A1c ranging from –0.3% to –0.8%, and/or weight ranging from –2.3 kg to –12.7 kg, fasting blood glucose (–1 mmol/L), waist circumference (–1 cm), and triglycerides (–60.1 mg/dL). These studies provided varied dietary recommendations from standard dietary guidelines, national health program guidelines, and a very low carbohydrate ketogenic diet.

Conclusions
This review provided evidence that web-based interventions may be an effective way to support dietary behavior change in people with T2DM, potentially leading to changes in glycemic control and other clinical outcomes. However, the evidence should be viewed as preliminary as there were only five studies included with considerable heterogeneity in terms of the diets recommended, the dietary assessment measures used, the complexity of the interventions, and the modes and methods of delivery.
Meeting Kids Where They Are At–A Substance Use and Sexual Risk Prevention Program via Telemedicine for African American Girls: Usability and Acceptability Study
Authors: Lopez Cristina , Gilmore Amanda K , Moreland Angela , Danielson Carla Kmett , Acierno Ron 
Published: June 2020

Background
Rural African American youth lack access to drug and sexual risk–taking prevention programs available in more urban areas. Recent data indicate that rural youth now use substances at higher rates and at younger ages than their urban peers.

Objective
This study aims to evaluate the initial usability and acceptability of a low-cost, technology-based approach to delivering effective, culturally tailored, integrated substance use disorder (SUD) and HIV risk behavior prevention programs to African American female youth to inform the use of this intervention via telemedicine for rural youth.

Methods
Effective SUD prevention strategies and emotion regulation skills were integrated into an existing evidence-based HIV risk reduction program culturally tailored for African American female adolescents—Sisters Informing, Healing, Living, and Empowering (SIHLE)—and delivered to 39 African American female youth via group telehealth. The evaluation of the resulting program, 12-session SIHLEplus, was completed by 27 girls who also completed self-report measures that assessed sexual risk behaviors (eg, number of partners and age of sex initiation), substance use, exposure to traumatic events, and emotion regulation.

Results
The descriptive and qualitative results of the pilot study demonstrate the initial usability and acceptability of delivering evidence-based prevention successfully via telehealth to help address health disparities in this vulnerable population.

Conclusions
Although more research is needed, the findings from this study suggest that SIHLEplus has demonstrated initial usability and acceptability.