bluuebunny/crossref_metadata_2025_split huggingface dataset:
“No drain, no gain”: Validation of novel quinsy simulation model
Authors: Bhalla Sanjana , O'Byrne Lisa , Beegun Issa , Amos Dora , Jones James Arwyn , Awad Zaid , Tolley Neil 
Published: December 2020

AbstractObjectives
To test a novel, low‐cost, home‐made model for needle aspiration of PTA.
To ascertain whether simulation‐based teaching using this model was superior to lecture‐based teaching in increasing confidence and reducing anxiety relating to PTA aspiration.
To assess whether there was an improvement in outcomes for PTA patients at one hospital following the delivery of a simulation‐based training session using our model.
MethodsWe designed two teaching sessions for junior doctors starting work in ENT: a simulation‐based teaching session using a low‐cost home‐made simulation model and a lecture‐based teaching session covering the same content. We asked the participants to complete pre‐ and post‐session surveys regarding confidence and anxiety levels and analyzed this data. We also retrospectively collected data over 3 months for patients referred to ENT with suspected PTA and assessed their outcomes. We assessed patient outcomes before and after the delivery of a simulation‐based training course using our model.ResultsSimulation‐based teaching using our model was shown to be associated with a statistically significant increase in junior doctors' confidence levels. Reaccumulation and reattendance rates for PTA following aspiration were 16.67% and 22.7% respectively preintervention and 0% and 7.14% respectively postintervention.ConclusionA regular simulation‐based teaching session should be introduced using a PTA aspiration model for junior doctors as it leads to increased confidence levels, and reduced reaccumulation and recurrence rates of PTA.Level of evidenceLevel 4.
Investigation of ionic liquids with and without graphene as lubricant additive for metal/metal and metal/PEEK contacts over a wide temperature range
Authors: Amann Tobias , Gatti Felix , Li Ke , Demirel Yakub , Kailer Andreas , Feng Hao , Yuan Chengqing 
Published: December 2020

AbstractThe aim of the work is to improve tribological properties of an ATF oil by means of additives. Two ionic liquids (IL) and one IL with 0.1 wt.% graphene were chosen as candidates. The ILs were selected because of their promising surface interactions and proven synergy with anti‐wear additives. However, little is known about the addition of ILs to fully formulated lubricants, especially in the low temperature range. Therefore, static and sliding friction as well as wear were measured in an application‐relevant temperature range of −30 to 100°C using a rotating ball‐on‐3‐plate test. The best additive for ATF oil for material pairing 100Cr6/polyether ether ketone was 5 wt.% [P66614][TMPP][G] (halogen‐free) and for 100Cr6/sintered iron 3 wt.% [P66614][BTA]. The additives lead to a wear reduction of more than 50%. Furthermore, it could be observed that the selected ILs have different effects on the friction behaviour at the temperatures investigated.
A self‐tracking phase retrieval algorithm used in distributed disturbance sensing
Authors: Mi Qiushi , Yu Houdan , Xiao Qian 
Published: December 2020

AbstractThe phase‐retrieval method with delayed calibration is widely used in fiber‐optic sensing structures to extract the distributed vibration messages. Yet, the performance of this method is not satisfactory when sudden changes are introduced in sensing path, for the DC compensation is not a slow variable under this situation. To improve the adjustment of interferometric fiber‐optic structure, a self‐tracking phase retrieval method is proposed. In the novel algorithm, the static state is tracked by calibrating DC compensation value in each retrieval period. When tested in the real scene with a 20 km‐long sensing fiber, the performance of the novel retrieval algorithm has been proved. Experimental results show that, compared with the conventional delayed calibration method, self‐tracking algorithm brings a better accuracy and uniformity performance in intrusion location test and shows a better adaptability to the environment.
Effects of mexiletine on hyperexcitability in sporadic amyotrophic lateral sclerosis: Preliminary findings from a small phase II randomized controlled trial
Authors: Weiss Michael D. , Macklin Eric A. , McIlduff Courtney E. , Vucic Steve , Wainger Brian J. , Kiernan Matthew C. , Goutman Stephen A. , Goyal Namita A. , Rutkove Seward B. , Ladha Shafeeq S. , Chen I‐Hweii Amy , Harms Matthew B. , Brannagan Thomas H. , Lacomis David , Zivkovic Sasha , Ma Maxwell , Wang Leo H. , Simmons Zachary , Rivner Michael H. , Shefner Jeremy M. , Cudkowicz Merit E. , Atassi Nazem ,   for the Mexiletine‐2 ALS Study Group
Published: December 2020

AbstractBackgroundTo collect preliminary data on the effects of mexiletine on cortical and axonal hyperexcitability in sporadic amyotrophic lateral sclerosis (ALS) in a phase 2 double‐blind randomized controlled trial.MethodsTwenty ALS subjects were randomized to placebo and mexiletine 300 or 600 mg daily for 4 wk and assessed by transcranial magnetic stimulation and axonal excitability studies. The primary endpoint was change in resting motor threshold (RMT).ResultsRMT was unchanged with 4 wk of mexiletine (combined active therapies) as compared to placebo, which showed a significant increase (P = .039). Reductions of motor evoked potential (MEP) amplitude (P = .013) and accommodation half‐time (P = .002), secondary outcome measures of cortical and axonal excitability, respectively, were also evident at 4 wk on mexiletine.ConclusionsThe relative stabilization of RMT in the treated subjects was unexpected and could be attributed to unaccounted sources of error or chance. However, a possible alternative cause is neuromodulation preventing an increase. The change in MEP amplitude and accommodation half‐time supports the reduction of cortical and axonal hyperexcitability with mexiletine.
Effect of molecular weight on mechanical properties and microstructure of 3D printed poly(ether ether ketone)
Authors: Xu Qinfei , Shang Yingshuang , Jiang Zilong , Wang Zhaoyang , Zhou Chenyi , Liu Xin , Yan Qixing , Li Xuefeng , Zhang Haibo 
Published: December 2020

AbstractFused deposition modeling (FDM) has been successfully applied to the manufacturing of poly(ether ether ketone) (PEEK) special engineering plastics. However, due to the unavoidable defects caused by FDM technology and the high melt viscosity of PEEK, 3D printed PEEK parts have poor mechanical properties. In this study, the mechanical properties and microstructure of PEEK printed with different nozzle temperatures and having various molecular weights were researched in detail. The results showed that PEEK‐033G with medium molecular weight had good fluidity. With a nozzle temperature of 410 °C and using a high‐temperature chamber 3D printing system, the defects of 3D printed PEEK‐033G were reduced significantly, and the tensile strength and flexural strength could reach 96 and 115 MPa, which is close to the performance obtained using injection molding. In addition, the tensile strength in the Z‐axis direction was applied to characterize the interlayer bond strength. With a decrease of the viscosity of PEEK, an increase of interlayer bond strength ensued. It is expected that these findings could provide more insight for 3D printing of PEEK. © 2020 Society of Chemical Industry
Breast cancer survivors' satisfying marriages predict better psychological and physical health: A longitudinal comparison of satisfied, dissatisfied, and unmarried women
Authors: Shrout M. Rosie , Renna Megan E. , Madison Annelise A. , Alfano Catherine M. , Povoski Stephen P. , Lipari Adele M. , Agnese Doreen M. , Farrar William B. , Carson William E. , Kiecolt‐Glaser Janice K. 
Published: December 2020

AbstractObjectiveBreast cancer survivors who experience psychological and physical symptoms after treatment have an increased risk for comorbid disease development, reduced quality of life, and premature mortality. Identifying factors that reduce or exacerbate their symptoms may enhance their long‐term health and physical functioning. This study examined how survivors' marital status and marital satisfaction—key health determinants—impacted their psychological and physical health trajectories to understand when, and for whom, marriage offers health benefits.MethodsBreast cancer survivors (n = 209, stages 0–IIIC) completed a baseline visit before treatment and two follow‐up visits 6 and 18 months after treatment ended. Women completed questionnaires assessing their marital status and satisfaction when applicable, as well as their psychological (depressive symptoms, stress) and physical (fatigue, pain) health at each visit.ResultsMarried women—both those in satisfying and dissatisfying marriages—experienced improvements in their depressive symptoms, stress, and fatigue from pretreatment to 6‐ and 18‐month posttreatment. Unmarried (i.e., single, divorced/separated, or widowed) women's depressive symptoms, stress, fatigue, and pain did not change over time, instead remaining elevated 6 and 18 months after treatment ended. Women in satisfying marriages also had fewer psychological and physical symptoms after treatment than those who were unmarried or in dissatisfying marriages.ConclusionsAlthough marriage was associated with improved psychological and physical health, the gains were most notable when survivors' marriages were satisfying. Thus, the quality of survivors' marriages, rather than the marriage itself, provided the most benefits to their psychological and physical health.
Characterizing and predicting sublethal shifts in mobility by multiple stored product insects over time to an old and novel contact insecticide in three key stored commodities
Authors: Morrison William R , Arthur Frank H , Bruce Alexander 
Published: December 2020

AbstractBACKGROUNDThere has been a push to diversify integrated pest management (IPM) programs away from exclusive fumigant use in food facilities. Residual insecticides increasingly have been included among plans. In stored products, sublethal toxicity has been neglected in favor of evaluating direct mortality. Here, we evaluated the movement of Tribolium castaneum, Rhyzopertha dominica, Sitophilus oryzae and Sitophilus zeamais in response to aged residues of an existing (Diacon IGR+® with 11.4% methoprene + 4.75% deltamethrin) and novel (Gravista® with 2.85% methoprene + 1.2% deltamethrin + 33.3% piperonyl butoxide synergist) residual insecticide.RESULTSUsing the maximum labeled rate and two exposure times for each species, we assessed distance moved and velocity on wheat, rice and corn. Assessments were made from commodity residues aged between 0 and 12 months (at 3‐month intervals). We found that after exposure, movement was reduced by 50–88% and equally by adults exposed to each insecticide formulation compared to untreated controls. After initial application, predicted distance moved increased from 4 to 14 m then 28 m in a 24 h period at 3 and 12 months post‐application, respectively. Effectiveness of each insecticide at suppressing movement generally declined by 9–12 month post‐application.CONCLUSIONSGiven the quick and dramatic increases in sublethal movement after initial application, our results suggest that sanitation programs in post‐harvest environments are extremely important and it may be beneficial to pair chemical control with monitoring to prevent dispersal of affected insects to new areas of a facility. Published 2020. This article is a U.S. Government work and is in the public domain in the USA
Reconciling different methods of high‐latitude blocking detection
Authors: Tyrlis Evangelos , Bader Jürgen , Manzini Elisa , Matei Daniela 
Published: December 2020

AbstractBlocking is associated with outbreaks of easterlies induced by a continuum of features including anticyclones, cyclones or both. Blocking identification methods disagree on the levels of high‐latitude blocking (HLB) activity. We investigate the cause of the disagreement in HLB activity over the Northern Hemisphere obtained by two 2D methods: the PV– index and the Absolute Geopotential Height (AGH) reversal method. Although both classify as absolute field methods, the former yields nearly twice the winter HLB activity of the latter method. We show that this discrepancy is caused by the addition of a poleward criterion in the AGH method that requires strong poleward westerlies. The additional criterion in the AGH method shifts the focus on the detection of blocking ridges and thus other blocking circulation patterns are under‐represented. Both methods agree on the climatology of midlatitude blocking because the poleward criterion has been tuned to capture the strong midlatitude blocking, but the discrepancy grows in high latitudes. HLBs are different because they occur on the northern flank of the westerlies and are associated with the equatorward displacement of the midlatitude jet. HLB anticyclones are weaker and do not induce strong poleward westerlies compared to their midlatitude counterparts. The implementation of a strict poleward criterion designed to identify midlatitude blocks rejects many HLBs. The use of the less strict cut‐off threshold (CT) of 0 m (°lat)−1 in the poleward criterion for latitudes higher than 60°N results in the convergence of climatology, interannual variability and trends of HLB between the two methods, especially during winter. The additional HLBs identified by the modified AGH algorithm develop from cyclonic wave breaking that is typical for oceanic blocking. The modified AGH method can be useful in detecting more robust HLB trends in climate model projections.
SAD: Verifying the scale, anisotropy and direction of precipitation forecasts
Authors: Buschow Sebastian , Friederichs Petra 
Published: December 2020

AbstractOne important attribute of meteorological forecasts is their representation of spatial structures. While several existing verification methods explicitly measure a structure error, they mostly produce a single value with no simple interpretation. Extending a recently developed wavelet‐based verification method, this study separately evaluates the predicted spatial scale, orientation and degree of anisotropy. The scale component has been rigorously tested in previous work and is known to assess the quality of a forecast similar to other, established methods. However, directional aspects of spatial structure are less frequently considered in the verification literature. Since important weather phenomena related to fronts, coastlines and orography have distinctly anisotropic signatures, their representation in meteorological models is clearly of interest. The ability of the new wavelet approach to accurately evaluate directional properties is demonstrated using idealized and realistic test cases from the MesoVICT project. A comparison of precipitation forecasts from several forecasting systems reveals that errors in scale and direction can occur independently and should be treated as separate aspects of forecast quality. In a final step, we use the inverse wavelet transform to define a simple post‐processing algorithm that corrects the structural errors. The procedure improves visual similarity with the observations, as well as the objective scores.
The effect of learning curve on perioperative outcomes of robotic gastrectomy in two western high‐volume centers
Authors: Solaini Leonardo , D'Ignazio Alessia , Marrelli Daniele , Marano Luigi , Avanzolini Andrea , Morgagni Paolo , Roviello Franco , Ercolani Giorgio 
Published: December 2020

AbstractIntroductionTo compare outcomes of robotic gastrectomy (RG) performed during the learning curve (P1) with those after its completion (P2).MethodsIn this retrospective study, all consecutive RG patients (n = 92) performed between 2008 and 2018 were included. Primary outcome was conversion rate.ResultsD2 lymphadenectomies were more common in P2 (41, 97.6%) than P1 (41, 82.0%) (p = 0.019). Conversions were 11 (22%) in P1 versus 2 (4.8%) in P2 (p = 0.006). Postoperative morbidity was comparable between the groups. Median hospital stay was significantly shorter in P2. The only factor significantly associated with conversion was P2 (odds ratio = 0.18; 95% confidence interval, 0.04–0.85;p = 0.039). The 5‐year overall survival in P1 was 79.6% versus 79.7% in P2 (p = 0.373).ConclusionsThe learning curve affected operative and postoperative outcomes: during the learning curve, conversion to open surgery was significantly more frequent, the number of D2 was higher and patients were discharged earlier.
Consensus of heterogeneous discrete‐time multi‐agent systems with noise over Markov switching topologies
Authors: Sun Fenglan , Lei Chengyu , Kurths Jürgen 
Published: December 2020

AbstractThis paper considers the mean‐square bounded consensus of heterogeneous discrete‐time multi‐agent systems with noise over fixed and Markov switching topologies. Firstly, a protocol is designed based on the agents' neighbor information with noise. Secondly, by using the Lyapunov function method, matrix analysis and probability theory, sufficient conditions for the mean‐square bounded consensus are given. Finally, several simulations are presented to illustrate the potential correctness of the results.
Secure graphical password based on cued click points using fuzzy logic
Authors: Ghiyamipour Fatemeh 
Published: December 2020

AbstractNowadays authentication technology is the most important means to ensure security. Alphanumeric username and password procedure is the most common authentication method. Users typically choose memorable passwords that are easy for attackers to guess, and assigned passwords by the system are difficult for users to remember. We present a graphical password based on cued recall in which is secured from shoulder surfing attack. Also, we propose an image encryption technique using a 2D cat map and edge detection technique in which it uses fuzzy logic inference to detect the edge of images. Then the user password is encrypted before storing it in the database using this method. Experiments illustrate that the proposed method has good performance in usability and security.
Moving TESOL forward: Increasing educators’ critical consciousness through a racial lens
Authors: Chan Elisabeth L. , Coney Lavette 
Published: December 2020

AbstractTeachers of English to Speakers of Other Languages (TESOL) professionals are immersed in multilingual and multicultural spaces. Thus, many consider TESOL educators innately culturally competent, yet others argue this is not the case (e.g., Lin et al., 2004). Moving the TESOL field from liberal to critical forms of multiculturalism (Kubota & Lin, 2006) requires consideration of power and privilege with increased critical consciousness (Freire, 1973). Using critical approaches through a racial lens, the authors examine the concepts of diversity, equity, and inclusion (DEI) for professional development and fostering a culture of social justice, where TESOL professionals recognize the ongoing reflexive work necessary to embrace diversity in all its forms. To determine educators’ level of critical consciousness, the authors propose using the Glasgow Group’s (2017) levels of inclusive school communities as a framework for locating educators along a continuum of critical consciousness. They guide readers through the six levels, providing self‐reflection questions, and recommending critical consciousness‐raising resources.
Higgs self-coupling measurements using deep learning in the $$ b\overline{b}b\overline{b} $$ final state
Authors: Amacker Jacob , Balunas William , Beresford Lydia , Bortoletto Daniela , Frost James , Issever Cigdem , Liu Jesse , McKee James , Micheli Alessandro , Saenz Santiago Paredes , Spannowsky Michael , Stanislaus Beojan 
Published: December 2020

AbstractMeasuring the Higgs trilinear self-couplingλhhhis experimentally demanding but fundamental for understanding the shape of the Higgs potential. We present a comprehensive analysis strategy for the HL-LHC using di-Higgs events in the fourb-quark channel (hh→ 4b), extending current methods in several directions. We perform deep learning to suppress the formidable multijet background with dedicated optimisation for BSMλhhhscenarios. We compare theλhhhconstraining power of events using different multiplicities of large radius jets with a two-prong structure that reconstruct boostedh→bbdecays. We show that current uncertainties in the SM top Yukawa couplingytcan modifyλhhhconstraints by∼20%. For SMyt, we find prospects of−0.8<$$ {\lambda}_{hhh}/{\lambda}_{hhh}^{\mathrm{SM}} $$λhhh/λhhhSM<6.6 at 68% CL under simplified assumptions for 3000 fb−1of HL-LHC data. Our results provide a careful assessment of di-Higgs identification and machine learning techniques for all-hadronic measurements of the Higgs self-coupling and sharpens the requirements for future improvement.
Design of Flat Vaults with Topological Interlocking Solids
Authors: Lecci Francesca , Mazzoli Cecilia , Bartolomei Cristiana , Gulli Riccardo 
Published: December 2020

AbstractThis paper investigates the principles that regulate complex stereotomic constructions as a starting point for the design of a new two-dimensional floor structure based on the principles of TIM (Topological Interlocking Materials). These interlocking systems use an assembly of identical Platonic solids which, due to the mutual bearing between adjacent units and the presence of a global peripheral constraint, lock together to form pure geometric shapes. This type of structure offers several advantages such as a high energy dissipation capacity and tolerance towards localised failure, which has made it a popular research topic over the last 30 years. The current research project includes a case study of an assembly of interlocking cubes to create a “flat vault”. The resulting vault design features a striking appearance and its geometry may be manipulated to achieve different two-dimensional solutions, provided certain geometric conditions necessary for the stability of the system are followed.
Renal ischemic adverse drug events related to tranexamic acid in women of child-bearing age: an analysis of pharmacovigilance data
Authors: Stämpfli Dominik , Weiler Stefan , Weiniger Carolyn F. , Burden Andrea M. , Heesen Michael 
Published: December 2020

Abstract
Purpose
In response to a large trial, the World Health Organization broadened their recommendation on tranexamic acid to be used for post-partum hemorrhage. A 2013 French periodic safety update report warned of an abnormally high rate of renal cortical necrosis associated with tranexamic acid and other drugs for severe post-partum hemorrhage. We aimed to identify the reporting incidence of adverse thrombo-embolic events among women in child-bearing age who received tranexamic acid, with a focus on renal vascular and ischemic conditions.

Methods
We analyzed individual case safety reports (ICSRs) on renal vascular and ischemic conditions, pulmonary thrombotic and embolic conditions, and peripheral embolism and thrombosis from the database of the World Health Organization – Uppsala Monitoring Centre (WHO-UMC). ICSRs were restricted to reports including tranexamic acid as a suspected drug, sex reported as female, and reported age between 18 and 44 years. Reporting odds ratios (RORs) and 95% confidence intervals (95% CIs) were calculated by comparing ICSRs on tranexamic acid to all other drugs in VigiBase.

Results
Within 2245 included ICSRs on tranexamic acid, we identified 29 reports of adverse renal vascular and ischemic conditions, 42 reports of pulmonary thrombotic and embolic conditions, and 41 reports of peripheral embolism and thrombosis. RORs were statistically significant by 32.6-fold (32.62, 95% CI: 22.50–47.29), 2.5-fold (2.52, 95% CI: 1.85–3.42), and 2.7-fold (2.67, 95% CI: 1.96–3.64), respectively, when compared to any other drug within VigiBase.

Conclusion
Tranexamic acid might bear an increased risk for renal ischemic adverse drug events in women of child-bearing age.