bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of vafidemstat in experimental autoimmune encephalomyelitis highlights the KDM1A/RCOR1/HDAC epigenetic axis in multiple sclerosis
Authors: Cavalcanti Fernando , Gonzalez-Rey Elena , Delgado Mario , Mestre Leyre , Guaza Carmen , Lufino Michele MP , Xaus Jordi , Mascaró Cristina , Lunardi Serena , Sacilotto Natalia , Dessanti Paola , Rotllant David , Navarro Xavier , Herrando-Grabulosa Mireia , Buesa Carlos , Maes Tamara 
Published: November 2020

Abstract
Background Vafidemstat (ORY-2001) is a clinical stage inhibitor of the Lysine Specific Demethylase KDM1A in development for treatment of neurodegenerative and psychiatric diseases. KDM1A demethylates H3K4me1/2 and together with the histone deacetylases HDAC1/2, it forms part of co-repressor complexes recruited by zinc finger factors to control transcription. The exact role of KDM1A in neuroinflammation remained to be explored. Methods Compounds were administered p.o. gavage to mice with MOG35-55 induced experimental autoimmune encephalomyelitis or mice infected with Theiler’s murine encephalomyelitis virus. Immune cell infiltration was analyzed by immunohistochemistry. Cytokine and chemokine levels were analyzed by ELISA. Genome wide gene expression in spinal cord and brain were analyzed by two-color microarray analysis and qRT-PCR.Results ORY-2001 improved the clinical score in mouse experimental autoimmune encephalomyelitis and in mice infected with the Theiler’s murine encephalomyelitis virus. The compound reduced lymphocyte egress and infiltration of immune cells in the spinal cord and prevented demyelination. ORY-2001 was more effective and/or faster acting than a sphingosine 1-phosphate receptor antagonist in the effector phase of the disease and reduced the induction of the inflammatory gene expression signature in the central nervous system more potently. Gene expression changes and axonal protection in animals, and protection against glutamate excitoxicity in spinal cord explants support that ORY-2001 has neuroprotective qualities.Conclusions ORY-2001 exerts therapeutic activity in two mouse models of multiple sclerosis. The anti-inflammatory properties of ORY-2001 are being tested in a Phase IIa clinical trial in patients with relapse remitting and secondary progressive multiple sclerosis, and in severely ill COVID-19 patients at risk for acute respiratory distress syndrome.
Depression and anxiety in the Malaysian urban population and their association with demographic characteristics, quality of life, and the emergence of the COVID-19 pandemic
Authors: Abdullah Mohammad Farris Iman Leong Bin , Yusof Hazwani Ahmad , Shariff Noorsuzana Mohd , Hami Rohayu , Nisman Noor Farahiya , Law Kim Sooi 
Published: November 2020

Abstract
The prevalence of depression and anxiety have been shown to be higher in the urban population compared with the rural population. The present study investigated the prevalence of depression, anxiety, and depression with comorbid anxiety and their associated factors in a random sample drawn from several urban communities in Malaysia. This study also compared the odds of developing depression, anxiety, and depression with comorbid anxiety before and after the emergence of the Coronavirus Disease 2019 (COVID-19) pandemic. We recruited 326 participants who were administered a sociodemographic characteristics questionnaire, the 21-item Depression, Anxiety, and Stress Scale (DASS-21), to assess the presence or absence of depression, anxiety, and depression with comorbid anxiety, and the World Health Organization Quality of Life-BREF (WHOQoL-BREF) to assess their QoL. The following prevalence values were obtained among the participants: depression, 23.9%; anxiety, 41.7%; and depression with comorbid anxiety, 19.9%. The factors significantly associated with higher odds of psychological complications included those assessed after the emergence of COVID-19 as a global pandemic and the presence of comorbid stress. Higher physical health-related QoL, psychological QoL, and environment-related QoL reduced the odds of psychological complications. Based on our findings, we recommended a few measures to curb psychological complications among the urban population, particularly as the battle to contain COVID-19 is still ongoing.
Chronobiology and Chronotherapy in Depression: Current Knowledge and Chronotherapeutic Promises
Authors: Rojas Milagros , Chávez-Castillo Mervin , Pírela Daniela , Ortega Ángel , Salazar Juan , Cano Clímaco , Chacín Maricarmen , Riaño Manuel , Batista María Judith , Díaz Edgar Alexis , Rojas-Quintero Joselyn , Bermúdez Valmore 
Published: November 2020

Background:
Depression is a heavily prevalent mental disorder. Symptoms of depression
extend beyond mood, cognition, and behavior to include a spectrum of somatic manifestations in all
organic systems. Changes in sleep and neuroendocrine rhythms are especially prominent, and disruptions
of circadian rhythms have been closely related to the neurobiology of depression. With the
advent of increased research in chronobiology, various pathophysiologic mechanisms have been
proposed, including anomalies of sleep architecture, the effects of clock gene polymorphisms in
monoamine metabolism, and the deleterious impact of social zeitgebers. The identification of these
chronodisruptions has propelled the emergence of several chronotherapeutic strategies, both pharmacological
and non-pharmacological, with varying degrees of clinical evidence.

Methods:
The fundamental objective of this review is to integrate current knowledge about the role
of chronobiology and depression and to summarize the interventions developed to resynchronize
biorhythms both within an individual and with geophysical time.

Results:
We have found that among the non-pharmacological alternatives, triple chronotherapywhich
encompasses bright light therapy, sleep deprivation therapy, and consecutive sleep phase
advance therapy-has garnered the most considerable scientific interest. On the other hand,
agomelatine appears to be the most promising pharmacological option, given its unique melatonergic
pharmacodynamics.

Conclusions:
Research in chronotherapy as a treatment for depression is currently booming. Novel
interventions could play a significant role in adopting new options for the treatment of depression,
with Tripe Cronotherapy standing out as the most promising treatment.
Information Sources, Risk Perception, and Efficacy Appraisal’s Prediction of Engagement in Protective Behaviors Against COVID-19 in China: Repeated Cross-sectional Survey
Authors: Rui Jian Raymond , Yang Keqing , Chen Juan 
Published: November 2020

Background
As the COVID-19 pandemic has become a major public health threat worldwide, it is critical to understand what factors affect individual engagement in protective actions. Because of its authoritarian political system and state-owned media system, how Chinese individuals engaged in protective actions against COVID-19 might be different compared to other countries.

Objective
The purpose of this study is to examine how the source of information about COVID-19, Chinese individuals’ risk perception of COVID-19 (ie, perceived severity and perceived susceptibility), and their efficacy appraisal in controlling COVID-19 (ie, response efficacy and self-efficacy) affected their engagement in protective actions. Additionally, this study aims to investigate whether there is any difference in these relationships throughout the duration of this pandemic.

Methods
A six-wave repeated cross-sectional survey (N=1942) was conducted in six major cities in China between February 7 and April 23, 2020. Participants’ reliance on expert versus inexpert sources for information about COVID-19, their perceived severity of and susceptibility to COVID-19, their response efficacy and self-efficacy, and their engagement in protective actions (staying at home, wearing a face mask, and washing hands) were measured. Demographic variables (sex, age, income, education, and city of residence), knowledge of COVID-19, and self-rated health condition were controlled.

Results
Reliance on expert sources did not become the major factor that motivated these actions until wave 3, and the negative effect of inexpert sources on these actions was limited to wave 2. Perceived severity encouraged some protective behaviors but its effect varied depending on the specific behavior. In addition, perceived severity exhibited a stronger effect on these behaviors compared to perceived susceptibility. The positive effect of response efficacy was only significant at waves 1 and 2, and limited to certain behaviors.

Conclusions
Chinese individuals’ engagement in protective behaviors might not entirely be their autonomous decision but a result of compliance with executive orders. After the early outbreak, expert sources started to facilitate protective behaviors, suggesting that it might take time to develop trust in these sources. The facilitating effect of perceived severity lasted throughout the duration of the pandemic, but that of response efficacy was limited to the early stage.
Analisis Pergeseran Titik Jaring Pemantau Candi Borobudur Mengacu ke ITRF 2008 Berdasarkan Data Pengamatan GPS pada Tahun 2003 dan 2012
Authors: Lestari Dwi , Dewanto Bondan Galih 
Published: November 2020

Pemantauan posisi Candi Borobudur bertujuan untuk menjaga warisan dunia. Salah satu caranya adalah dengan pembangunan bench mark (BM) atau titik kontrol untuk pemantauan deformasi menggunakan Global Positioning System (GPS). Pengukuran menggunakan teknologi GPS untuk pemantauan stabilitas Candi Borobudur telah dilakukan pada tahun 2002, 2003, dan 2012, menggunakan Global Kalman Filter VLBI dan analisis GPS dan mengacu pada ITRF2000 untuk menganalisis pergeseran horisontal. ITRF menuntut pemutakhiran data koordinat titik-titik kontrol secara periodik. Perbedaan penggunaan versi ITRF pada pengolahan data GPS berdampak pada perbedaan ketelitian estimasi posisi, besar kecepatan dan arah pergeseran titik-titik kontrol. Tujuan dari penelitian ini adalah untuk mengukur estimasi posisi, kecepatan, dan arah pergerakan dari titik control GPS berdasarkan data 2003 dan 2012 dan mengacu pada ITRF2008. Masing-masing kala melalui tahapan regional processing dan local processing. Koordinat dari hasil local processing GAMIT/GLOBK selanjutnya dibandingkan dengan koordinat hasil olahan mengacu ITRF2000 yang telah ditransformasi menjadi koordinat mengacu ITRF2008. Analisis pergeseran titik berdasarkan koordinat dan hasil dari data 2003 dan 2012. Penelitian ini menghasilkan bahwa perbedaan posisi dan akurasi pada pengolahan regional dan lokal mengindikasikan transformasi dari ITRF2000 ke ITRF2008 berada pada standar deviasi yang dihasilkan GAMIT dan GLOBK yang mengacu pada ITRF2008. Selanjutnya, rata-rata nilai pergeseran horisontal periode 2003 dan 2012 adalah 261 mm arah tenggara (SE) yang serupa dengan penggunaan ITRF2000 pada penelitian sebelumnya. Secara umum, perataan jaring Candi Borobudur yang mengacu pada ITRF 2008 lebih akurat dibandingkan penelitian sebelumnya yang mengacu pada ITRF2000.
PHYTOCHEMICAL SCREENING OF INFLORESCENCE OF PIPER BETLE
Authors: KUMAR SUSHMA S. , PAULY SONA V. , G. SOWMYASHREE 
Published: November 2020

Objective: The objective of the current study is to determine the phytoconstituents present in the Inflorescence of Piper betle (IPB).
Methods: Phytochemical screening was performed to analyse the phytoconstituents present in IPB and the same was identified by TLC. The phytoconstituents were also estimated quantitatively.
Results: Phytochemical screening showed the presence of alkaloids, flavonoids, saponins, tannins and polyphenols. TLC results indicated and confirmed the presence of alkaloids, polyphenols, flavonoids and tannins. On quantification IPB was found to contain 4.2±1.661 mg/ml and 1.523±0.156 mg/ml of flavonoids and tannins respectively.
Conclusion: The present study suggests that Inflorescence of Piper betle can be a good source of secondary metabolites.
Analisis Putusan Hakim Pengadilan Tindak Pidana Korupsi Denpasar (Putusan No : 42/Pid.Sus-TPK/2015/PN Dps)
Authors: Suartana I Made , Widyantara I Made Minggu , Sugiartha I Nyoman Gede 
Published: November 2020

The aim and purpose of this research is to analyze “the abuse of authority in official travel orders that have implications for corruption.” The legal issues arising out of this research comprises: What is the Legal Basis of Denpasar Corruption Court Judges in taking into consideration and imposing criminal sanctions under Decision No. 42/Pid.Sus-TPK/2015/PN Dps, and What is the Juridical Analysis toward the Decision No. 42/Pid.Sus-TPK/2015/PN Dps issued by Denpasar Corruption Court Judges. This research is a normative legal research adopting a number of approaches i.e. Statute Approach, Conceptual Approach, and Case Approach. Based on this research’s output may conclude that: 1) Crime/Corruption Offense is a crime specifically governed by Law No. 20 of 2001 of which law was enacted as an amendment to previous Law No. 31 of 1999 that also govern Eradication of Crime or Corruption; 2) By virtue of Decision No. 42/Pid.Sus-TPK/2015/Pengadilan Negeri Denpasar, Defendant was proven to have infringed Article 3 of Law No. 31 of 1999 amended by Law No. 20 of 2001 on Crime/Corruption Eradication that under the decision of which all acts committed by the Defendant have been proven to infringed all elements of crime charged in the subsidiary indictment as follows: 1) Element of “Every person”; 2) Element of “The aim of benefiting themselves or other people or a corporation”; 3) The Element of “Abusing the authority, opportunity or facility provided to him/her due to his/her position or office; and 4) Element of “Probable detrimental to the State's finance or economys.”
Санкт-Петербург - крупномасштабные градостроительные проекты на берегу Финского залива
Authors: Энгель Барбара , Малько Анастасия 
Published: November 2020

Проблемы городского планирования в Санкт-Петербурге носят комплексный характер, к ним относится как необ­ходимость строительства нового жилья и реконструкции микрорайонов панельной застройки, так и преобразование многочисленных промышленных зон, обновление и рас­ширение транспортной инфраструктуры и многое другое. Три крупномасштабных градостроительных проекта меняют силуэт Санкт-Петербурга на Финском заливе: Балтийская жемчужина на юге, Лахта-центр с башней Газпрома на севере и «Голден-Сити» (Golden City) в новом порту для круизных лайнеров. На данный момент не прослеживается общая концепция пространственного развития прибрежной зоны города. Для устойчивого развития Санкт-Петербурга необхо­дим сдвиг парадигмы в городском планировании[1].

[1] Авторская редакция статьи «Golden-City St-Petersburg», опублико­ванной в журнале «Баувельт» (Bauwelt), 2020, № 6 (источник: https://www. bauweit.de/das-heft/heftarchiv/GLaenzende-GoLden-City-St.-Petersburg- BaLtic-Ostsee-3512665.html).
PENINGKATAN HASIL BELAJAR IPS SISWA KELAS V SDN 37 PEKANBARU MELALUI STRATEGI SENTENCE JOURNAL
Authors: Bela Putri , Erni Sukma 
Published: November 2020

Penelitian ini bertujuan untuk mengetahui efektifitas pembelajaran dengan strategi sentence jurnal dalam meningkatkan hasil belajar IPS pada tingkat SD. Dilaksanakan dengan menggunakan metode penelitian tindakan kelas (PTK) dengan 2 siklus dan 4 kali tatap muka. Hasil penelitian menunjukkan terdapat peningkatan hasil belajar secara bertahap dari hasil tes pertama dan kedua. Dalam proses pembelajaran yang dilaksanakan guru terjadi optimalisasi tindakan mengikuti tahapan strategi sebanyak 97,2% pada tatap muka ke 4, diikuti dengan peningkatan kegiatan belajar siswa sebanyak 87,7%. Hasil tes akhir setelah pembelajaran dilaksanakan adalah 83,3 % mencapai ketuntasan sesuai standar yang ditetapkan sekolah yakni 76. Temuan penelitian tersebut menegaskan bahwa strategi sentence jurnal dapat digunakan sebagai salah satu strategi yang dapat meningkatkan hasil belejar IPS siswa tingkat sekolah dasar
Pemetaan Pengembangan Potensi Vokasi Pesantrenpreneur (Studi Kasus di Pondok Pesantren Darussalam Dukuhwaluh Purwokerto)
Authors: Hilyatin Dewi Laela 
Published: November 2020

In the perspective of human resource development, Islamic boarding schools today are no longer seen as religious institutions. More than that, Islamic boarding schools are considered capable of holding broader social and educational functions, namely the professional craters at the same time as Muslim converts. As many researchers have revealed, today most Islamic boarding schools have vocational specifications as institutional branding: cultural centers, language centers, community counseling centers, centers of creative economic development and others. Darussalam Pesantren as one of the developing boarding schools in Purwokerto has quite a lot of potential that has not yet been mapped and developed. This research is directed to focus on discussing the methodology of mapping potentials and developing potential vocational messages for pesantren Darussalam schools.
From the research conducted it was concluded that the potential of Darussalam pesantren included: HR, facilities and infrastructure, the geographical location of the pesantren, the pesantren network and the legality of the pesantren. The mapping methodology includes: data collection, data presentation, data analysis and map usage. Vocational pesantrenpreneur that can be developed focus on economic and language development with three models, namely: Entrepreneurial Extracurricular, Student Internship and Industrial Maturity, Consolidation of Political Politics
PENGARUH KEDISIPLINAN DAN MOTIVASI BELAJAR TERHADAP PRESTASI BELAJAR PESERTA DIDIK KELAS XI SMK NEGERI 3 MAUMERE
Authors: Wisang Imelda 
Published: November 2020

Latar belakang penelitian ini adalah rendahnya disiplin pada peserta didik SMK Negeri 3 Maumere.Penelitian ini bertujuan untuk menganalisis pengaruh Kedisiplinan dan Motivasi Belajar terhadap Prestasi Peserta Didik Kelas XI SMK Negeri 3 Maumere baik secara parsial maupun secara simultan. Populasi dalam penelitian ini adalah peserta didik SMK Negeri 3, berjumlah 170 orang. Karena populasinya terbatas, maka penelitian ini dilakukan secara random sampling. Data dikumpulkan melalui quisioner dan dianalisis menggunakan metode statistik deskriptif dan statistik inferensial yaitu regresi linier berganda. Pengujian hipotesis dilakukan melalui Uji F dan Uji t. Hasil uji statistik menunjukkan bahwa variabel Kedisiplinan nilai thitung sebesar 2.937dengan nilai signifikan sebesar 0.004. Nilai signifikansi ini lebih kecil dari tingkat alpha yang digunakan 5% (0,05), maka keputusannya adalah menolak hipotesis nol (Ho) dan menerima hipotesis alternatif (Ha), bahwa secara parsial variabel Kedisiplinan Belajar(X1) berpengaruh signifikan terhadap variabel Prestasi Belajar. Sedangkan variabel Motivasi Belajar menunjukkan bahwa nilai thitung sebesar 2.888 dengan nilai signifikan sebesar 0.005. Nilai signifikansi ini lebih kecil dari tingkat alpha yang digunakan 5% (0,05), maka keputusannya adalah menolak hipotesis nol (Ho) dan menerima hipotesis alternatif (Ha), bahwa secara parsial variabel Motivasi Belajar berpengaruh signifikan terhadap variabel Prestasi Belajar. Selain itu, hasil koefisien determinasi (R2) sebesar 0.122 yang berarti bahwa kedua variabel bebas dalam penelitian ini (Kedisiplinan Belajar, dan Motivasi Belajar) mampu menjelaskan variasi naik turunnya Prestasi Belajar SMK Negeri 3 Maumere sebesar 12.2%. Peserta didik SMK Negeri 3 Maumere disarankan untuk terus meningkatkan dan memperbaiki beberapa sub indicator disiplin dan Prestasi Belajar yang mempunyai nilai indeks lebih rendah dari nilai indeks Variabel.
EKSISTENSI LELUHUR DALAM KEHIDUPAN MASYARAKAT NIAS
Authors: Wiradnyana Ketut 
Published: November 2020

Masyarakat Nias menganut pola kekerabatan patrilineal, yang dalam berbagai aspek kebudayaannya sangat terkait dengan garis keturunan laki-laki. Konsep patrilineal tersebut sangat terkait dengan ide konsepsi pemujaan terhadap leluhur. Konsepsi pemujaan terhadap leluhur itu merupakan salah satu konsepsi religi pada budaya Megalitik dan berkaitan dengan konsepsi ekonomi dan sosial. Berkenaan dengan itu maka konsepsi pemujaan leluhur menjadi sangat berperan penting dalam berbagai aspek kehidupan masyarakatnya. Jadi, upaya memahami kebudayaan masyarakat Nias itu diantaranya dapat juga dikenali melalui pemahaman tentang eksistensi leluhur, dengan berbagai peranannya di masyarakat. Pencapaiannya melalui alur pemikiran deskriptif-kualitatif yang dilakukan atas hasil penelitian arkeologis, etnografis dan juga mikrobiologi, pada akhirnya data yang terhimpun dianalisis dan dibandingkan dengan berbagai aspek pada kebudayaan dalam kaitannya dengan konsep leluhur pada masyarakat tradisional lainnya. Metode itu akan membantu mengidentifikasi berbagai aspek yang berkaitan dengan leluhur masyarakat Nias, seperti halnya aspek asal muasal dan waktu migrasinya ke Pulau Nias beserta berbagai peran konsepsi leluhur pada kehidupan masyarakatnya.
Gene expression analysis in modeling Parkinson’s disease
Authors: Руденок М.М. , Алиева А.Х. , Колачева А.А. , Угрюмов М.В. , Сломинский П.А. , Шадрина М.И. 
Published: November 2020

Несмотря на очевидный прогресс, достигнутый в изучении молекулярно-генетических факторов и механизмов патогенеза болезни Паркинсона (БП), в настоящее время стало ясно, что нарушения в структуре ДНК не описывают весь спектр патологических изменений, наблюдаемых при развитии заболевания. В настоящее время показано, что существенное влияние на патогенез БП могут оказывать изменения на уровне транскриптома. В работе были использованы мышиные модели досимптомной стадии БП, поздней досимптомной и ранней симптомной (РСС) стадиями БП. Для полнотранскриптомного анализа пулов РНК тканей черной субстанции и стриатума мозга мышей использовались микрочипы MouseRef-8 v2.0 Expression BeadChip Kit («Illumina», США). Полученные данные указывают на последовательное вовлечение транскриптома в патогенез БП, а также на то, что изменения на транскриптомном уровне процессов транспорта и митохондриального биогенеза могут играть важную роль в нейродегенерации при БП уже на самых ранних этапах.
Parkinson’s disease (PD) is a complex systemic disease, mainly associated with the death of dopaminergic neurons. Despite the obvious progress made in the study of molecular genetic factors and mechanisms of PD pathogenesis, it has now become clear that violations in the DNA structure do not describe the entire spectrum of pathological changes observed during the development of the disease. It has now been shown that changes at the transcriptome level can have a significant effect on the pathogenesis of PD. The authors used models of the presymptomatic stage of PD with mice decapitation after 6 hours (6 h-PSS), presymptomatic stage with decapitation after 24 hours (24 h-PSS), advanced presymptomatic (Adv-PSS) and early symptomatic (ESS) stages of PD. For whole transcriptome analysis of RNA pools of the substantia nigra and mouse striatum, the MouseRef-8 v2.0 Expression BeadChip Kit microchips (Illumina, USA) were used. As a result of the analysis of whole transcriptome data, it was shown that, there are a greater number of statistically significant changes in the tissues of the brain and peripheral blood of mice with Adv-PSS and ESS models of PD compared to 6 h-PSS and 24 h-PSS models. In general, the obtained data indicate the sequential involvement of the transcriptome in the pathogenesis of PD, as well as the fact that changes at the transcriptome level of the processes of transport and mitochondrial biogenesis can play an important role in neurodegeneration in PD at an early stage.