bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consequences of agricultural total factor productivity growth for the sustainability of global farming: accounting for direct and indirect land use effects
Authors: Villoria Nelson 
Published: October 2019

AbstractMost of the growth in agricultural output in the last thirty years comes from increases in the efficiency with which both land and non-land inputs are used. Recent work calls for a better understanding of whether this efficiency, known as total factor productivity (TFP), contributes to a more sustainable food system. Key to this understanding is the documented phenomenon that, instead of saving lands, the introduction of technologies that improve agricultural productivity encourage cropland expansion. We extend the results of a recently published econometric model of cross-country cropland change and TFP growth to explore the extent to which improvements in technology were associated with lower greenhouse emissions from land conversion to agriculture as well as with lower land conversion pressures in biodiversity-rich biomes. We focus on the decade of 2001–2010, a period in which our sample of 70 countries (≈75% of global croplands) experienced net land contraction. Except in sub-Saharan Africa and South and East Asia, regional TFP growth was associated with regional land expansion, thus confirming the existence of Jevons paradox in most regions of the world. However, such expansion was more than offset by indirect land use effects stemming from increases in productivity somewhere else. These indirect effects are far from trivial. In the absence of TFP growth, our estimates suggest that ≈125 Mha would have been needed to satisfy demand, half of which are in the four most biodiverse biomes of the world; estimated land use emissions from the ensuing changes in land use range from a lower bound of 17 Gt CO2eq to an upper bound of 84 Gt CO2eq, depending on whether the expansion would have occurred on pasturelands or forest, in contrast to the ≈1 to 15 Gt CO2eq imputed to observed cropland expansion. Our projections of the land needed to satisfy projected growth in TFP per capita during 2018–2023 indicate that current rates of TFP growth are insufficient to prevent further land expansion, reversing in most cases the in-sample trends in land contraction observed during 2001–2010.
Sexual goals and perceptions of goal congruence in individuals’ PrEP adoption decisions: A mixed-methods study of gay and bisexual men who are in primary relationships
Authors: Gamarel Kristi E , Golub Sarit A 
Published: October 2019

Abstract

Background
Although health goals are recognized as a central feature of health behavior theories, the relational context through which goals are conceptualized is often overlooked. Interdependence theory represents a valuable framework for understanding goals in the adoption of health behaviors, such as pre-exposure prophylaxis (PrEP), among gay and bisexual men in primary relationships.

Purpose
We examined the content and focus of men’s sexual health goals, as well as whether goal content, goal focus, or perceptions of goal congruence with a primary partner were related to PrEP adoption among gay and bisexual men in primary relationships.

Methods
Mixed-methods data were collected from a PrEP demonstration project from 145 HIV-negative gay and bisexual men in primary relationships. Participants reported their sexual health goals and completed measures of perceptions of goal congruence, relationship factors, and sociodemographic factors.

Results
Three main goal content categories were identified: prevention, satisfaction, and intimacy. In expressing these goals, participants framed them with either a self-focus or a relationship-focus. Men in serodiscordant relationships reported more intimacy goals and greater perceptions of goal congruence. There were no differences in goal content or focus by sexual agreement. In the multivariable logistic regression model, perceived goal congruence was associated with PrEP adoption, over and above covariates.

Conclusions
Intimate relationships play a significant role in the formation of health-related goals. Goal content, focus, and perceived congruence with partners may represent important targets for HIV prevention interventions for gay and bisexual men in primary relationships, especially in the context of PrEP.
The Role of Self-regulation Failures and Self-care in the Link Between Daily Sleep Quality and Blood Glucose Among Adults with Type 1 Diabetes
Authors: Tracy Eunjin Lee , Berg Cynthia A , Kent De Grey Robert G , Butner Jonathan , Litchman Michelle L , Allen Nancy A , Helgeson Vicki S 
Published: October 2019

Abstract

Background
Sleep, a process that restores the body’s ability to self-regulate, may be one important factor affecting self-care behaviors and blood glucose (BG) levels. The link between sleep quality, self-care behaviors, and BG levels may occur by sleep-altering daily self-regulatory failures.

Purpose
This study examined whether the relation between sleep quality and self-care behaviors occurred through self-regulation failures and whether the relation between sleep quality and BG levels occurred through self-regulation failures and self-care behaviors sequentially.

Methods
One hundred and ninety-nine adults with type 1 diabetes (T1D) completed an online questionnaire for 14 days in which they reported sleep quality, self-regulation failures, and self-care behaviors. BG levels were gathered from glucometers. Analyses involved multilevel mediation models and focused on daily within-person and between-person variability of sleep quality.

Results
Better daily sleep quality was associated with higher self-care behaviors at both within-person and between-person levels, and self-regulation failures mediated the association between daily sleep quality and daily self-care behaviors at both within-person and between-person levels. Better daily sleep quality was associated with better BG levels at the within-person level and self-regulation behaviors and self-care behaviors sequentially mediated the association between daily sleep quality and daily BG levels at the within-person level.

Conclusion
This study provides a process account of the importance of daily sleep quality of adults with T1D, as well as one potential mechanism—self-regulation—that may explain the effect of sleep quality on diabetes outcomes.
Mosaicism for KCNJ5 Causing Early-Onset Primary Aldosteronism due to Bilateral Adrenocortical Hyperplasia
Authors: Maria Andrea G , Suzuki Mari , Berthon Annabel , Kamilaris Crystal , Demidowich Andrew , Lack Justin , Zilbermint Mihail , Hannah-Shmouni Fady , Faucz Fabio R , Stratakis Constantine A 
Published: October 2019

Abstract

BACKGROUND
Somatic variants in KCNJ5 are the most common cause of primary aldosteronism (PA). There are few patients with PA in whom the disease is caused by germline variants in the KCNJ5 potassium channel gene (familial hyperaldosteronism type III—FH-III).

METHODS
A 5-year-old patient who developed hypertension due to bilateral adrenocortical hyperplasia (BAH) causing PA had negative peripheral DNA testing for any known genetic causes of PA. He was treated medically with adequate control of his PA but by the third decade of his life, due to worsening renal function, he underwent bilateral adrenalectomy.

RESULTS
Focused exome sequencing in multiple nodules of his BAH uncovered a “hot-spot” pathogenic KCNJ5 variant, while repeated Sanger sequencing showed no detectable DNA defects in peripheral blood and other tissues. However, whole exome, “deep” sequencing revealed that 0.23% of copies of germline DNA did in fact carry the same KCNJ5 variant that was present in the adrenocortical nodules, suggesting low level germline mosaicism for this PA-causing KCNJ5 defect.

CONCLUSIONS
Thus, this patient represents a unique case of BAH due to a mosaic KCNJ5 defect. Undoubtedly, his milder PA compared with other known cases of FH-III, was due to his mosaicism. This case has a number of implications for the prognosis, treatment, and counseling of the many patients with PA due to BAH that are seen in hypertension clinics.
Hymenasplenium volubile: documentation of its gametophytes and the first record of a hemiepiphyte in the Aspleniaceae
Authors: Watts Jacob L , Moran Robbin C , Watkins James E 
Published: October 2019

Abstract

Background and Aims
Through careful field examination of the growth habit of the gametophytes and sporophytes of Hymenasplenium volubile across an ontogenetic series, we aim to understand better the evolution of epiphytism in this poorly understood group of ferns

Methods
We made field observations of H. volubile sporophytes and gametophytes, and brought specimens back to the lab for microscopic analysis. In the field, sporophytes at each ontogenetic stage were photographed to document the species’ growth habit. We used an existing phylogeny to optimize growth form of New World Hymenasplenium.

Key Results
Young sporophytes were at first fully epiphytic and produced one or two long feeding roots that extend to the soil where they branch profusely. The feeding roots remain in contact with the soil throughout the life of the plant. Thus, H. volubile is a hemiepiphyte. While immature, gametophytes are appressed to the tree trunk, but, as their gametangia mature, their lower margin lifts upward, imparting a shelf-like appearance to the thallus. The thallus attaches to the substrate by branched rhizoids produced along the margin of the thallus in contact with the substrate.

Conclusions
Hemiepiphytes are a key link in the evolution of epiphytic ferns and may act as a bridge between the forest floor and the canopy. Our finding is the first report of hemiepiphytism in Aspleniaceae, a large lineage with many epiphytic and terrestrial taxa. This work serves as an important model to understand the evolution of epiphytism in this group specifically and in ferns in general. The majority of our understanding of fern gametophyte biology is derived from laboratory studies. Our efforts represent a fundamental contribution to understanding fern gametophyte ecology in a field setting.
Evaluation of the role of Rhizobacteria in controlling root knot nematode (RKN) infection in Lycopersicon esculentum plants by modulation in the secondary metabolite profiles
Authors: Khanna Kanika , Jamwal Vijay Lakshmi , Sharma Anket , Gandhi Sumit G , Ohri Puja , Bhardwaj Renu , Al-Huqail Asma A , Siddiqui Manzer H , Marraiki Najat , Ahmad Parvaiz 
Published: October 2019

Abstract
Environmental stress imposes negative impacts on the growth and development of the crop plants. The present study was designed to assess the effect of PGPR (Pseudomonas aeruginosa and Burkholderia gladioli) on plant pigments and phenolic compounds in 10-days-old root knot nematode (RKN)-infected Lycopersiconesculentum seedlings. The levels of different osmoprotectants and organic acids were also evaluated in nematode-infected L. esculentum seedlings. Our results revealed that nematode-infected seedlings had reduced levels of plant pigments(chlorophyll (70.5%), carotenoids (64.8%), and xanthophylls (34.3%)) and enhanced levels of phenolic compounds(total phenols (40.3%), flavonoids (80.9%), anthocyanins (28.9%), and polyphenols (366.1%)), osmoprotectants(total osmolytes (15.3%), total carbohydrates (54.9%), reducing sugars (45.3%), trehalose (94.5%), glycine betaine (59.01%) and proline (69.6%) and (citric acid (28.4%), fumaric acid (18.16%), succinic acid (179.9%), and malic acid (21.7%)). The levels of these metabolites increased after inoculation with P. aeruginosa and B. gladioli. The expression of genes encoding different enzymes pertaining to phenols and organic acid metabolism were also studied. The expression of genes was elevated in nematode-infected plants i.e. CHS (chalcone synthase) by 1.32 folds, PAL (phenylalanine ammonia lyase) by 1.16 folds, CS (citrate synthase)1.6 folds, SUCLG1 (succinyl Co-A ligase) by 1.19 folds, SDH (succinate dehydrogenase) by 1.92 folds, FH (fumarate hydratase) by 2.4 foldsand malate synthase (MS) by 1.26 folds and further upregulated after PGPR inoculation. This study demonstrates the importance of PGPR in managing nematode infection in plants through alteration in the synthesis of different secondary metabolites in plants.
A Solutions-Focused Translational Research Framework for Wildlife Health
Authors: Peters Andrew , Carver Scott , Skerratt Lee F , Meredith Anna , Woods Rupert 
Published: October 2019

Abstract
Wildlife health is of emerging relevance for conservation, human health, and domestic animal health. Increased research on wildlife health problems has not been accompanied by a relative increase in effective solutions. Translational research was developed in human health to overcome blocks impeding the development of solutions out of basic research, and a translational research framework is proposed to overcome the same barriers in wildlife health. This framework has four translational phases: problem definition, potential solution development, efficacious solution development, and effective solution development. Implementation of translational research will require a restructuring of the wildlife health research enterprise with a shift, supported by funding sources and journals, to solutions-focused research including later translational phases, the creation of more deeply integrated multidisciplinary and interdisciplinary teams incorporating better representation from human social sciences, and the inclusion of end user and stakeholder participation in all phases of research.
Brain Morphological Dynamics of Procrastination: The Crucial Role of the Self-Control, Emotional, and Episodic Prospection Network
Authors: Chen Zhiyi , Liu Peiwei , Zhang Chenyan , Feng Tingyong 
Published: October 2019

AbstractGlobally, about 17% individuals are suffering from the maladaptive procrastination until now, which impacts individual’s financial status, mental health, and even public policy. However, the comprehensive understanding of neuroanatomical understructure of procrastination still remains gap. 688 participants including 3 independent samples were recruited for this study. Brain morphological dynamics referred to the idiosyncrasies of both brain size and brain shape. Multilinear regression analysis was utilized to delineate brain morphological dynamics of procrastination in Sample 1. In the Sample 2, cross-validation was yielded. Finally, prediction models of machine learning were conducted in Sample 3. Procrastination had a significantly positive correlation with the gray matter volume (GMV) in the left insula, anterior cingulate gyrus (ACC), and parahippocampal gyrus (PHC) but was negatively correlated with GMV of dorsolateral prefrontal cortex (dlPFC) and gray matter density of ACC. Furthermore, procrastination was positively correlated to the cortical thickness and cortical complexity of bilateral orbital frontal cortex (OFC). In Sample 2, all the results were cross-validated highly. Predication analysis demonstrated that these brain morphological dynamic can predict procrastination with high accuracy. This study ascertained the brain morphological dynamics involving in self-control, emotion, and episodic prospection brain network for procrastination, which advanced promising aspects of the biomarkers for it.
A new structural break test for panels with common factors
Authors: Zhu Huanjun , Sarafidis Vasilis , Silvapulle Mervyn J 
Published: October 2019

SummaryThis paper develops new tests against a structural break in panel data models with common factors when T is fixed, where T denotes the number of observations over time. For this class of models, the available tests against a structural break are valid only under the assumption that T is ‘large’. However, this may be a stringent requirement—more commonly so in datasets with annual time frequency, in which case the sample may cover a relatively long period even if T is not large. The proposed approach builds upon existing generalized method of moments methodology and develops Distance-type and Lagrange Multiplier-type tests for detecting a structural break, both when the break point is known and when it is unknown. The proposed methodology permits weak exogeneity and/or endogeneity of the regressors. In a simulation study, the method performed well, in terms of size and power, as well as in terms of successfully locating the time of the structural break. The method is illustrated by testing the so-called ‘Gibrat’s Law’, using a dataset from 4,128 financial institutions, each one observed for the period 2002–2014.
Evaluation of the effectiveness of a tailored mobile application in increasing the duration of wear of thermoplastic retainers: a randomized controlled trial
Authors: Al-Moghrabi Dalya , Pandis Nikolaos , McLaughlin Kieran , Johal Ama , Donos Nikolaos , Fleming Padhraig S 
Published: October 2019

Summary

Background
The ‘My Retainers’ mobile application is a patient-informed intervention designed to enhance removable retainer wear and associated patient experiences during the retention phase.

Objectives
To evaluate the effect of receiving the ‘My Retainers’ application on objectively assessed thermoplastic retainer (TPR) wear time, stability, periodontal outcomes, patient experiences, and knowledge related to retainers.

Materials and methods
Eighty-four participants planned for removable retention with TPRs were assigned either to receive the ‘My Retainers’ application or to control not receiving electronic reminders during the 3-month period. Randomization was based on computer-generated random numbers and allocation was concealed using opaque, sealed envelopes. The primary outcome was objectively assessed retainer wear recorded using an embedded TheraMon® micro-electronic sensor. Secondary outcomes, including irregularity of the maxillary and mandibular incisors, plaque levels, bleeding on probing and probing depth, were assessed at baseline and 3-month follow-up; and analysed using a series of mixed models. Experiences and knowledge related to orthodontic retainers were recorded using questionnaires. The outcome assessor was blinded when possible.

Results
Receipt of the mobile application resulted in slightly higher median wear time (0.91 hours/day); however, this difference was not statistically significant (P = 0.56; 95% confidence interval [CI]: −2.19, 4.01). No significant differences were found between the treatment groups in terms of stability (P = 0.92; 95% CI: −0.03, 0.04), plaque levels (P = 0.44; 95% CI: −0.07, 0.03), bleeding on probing (P = 0.61; 95% CI: −0.05, 0.03) and probing depth (P = 0.79; 95% CI: −0.09, 0.07). Furthermore, similar levels of patient experiences (P = 0.94) and knowledge related to retainers (P = 0.26) were found. However, marginally better levels of knowledge were identified in the intervention group. No harms were observed.

Limitations
A relatively short follow-up period with the study confined to a single-center in a university-based hospital.

Conclusions
Provision of the bespoke ‘My Retainers’ application did not lead to an improvement in adherence with TPR wear over a 3-month follow-up period. Further refinement and research are required to develop and investigate means of enhancing adherence levels.

Clinical registration
NCT03224481.
Mandibular propulsion appliance for adults with Class II malocclusion: a systematic review and meta-analysis
Authors: González Espinosa Daybelis , Santos Milena , Mendes Sissy Maria dos Anjos , Normando David 
Published: October 2019

Summary

Background
The effects of mandibular propulsion appliances in adults have some controversial results. While some authors claim that its use in non-growing patients could produce some dentoskeletal effects, other studies indicate that Class II correction occurs only through significant dental effects.

Objective
To evaluate the effects in non-growing Class II patients with mandibular retrusion, promoted by the treatment with mandibular propulsion appliances and determine if they produce mandibular changes.

Methods
The research was carried out in nine electronic databases and additional manual searches up to July 2019. Selection criteria were no restriction was placed on date and publication language. Randomized or non-randomized clinical trials with/without control were included. They must evaluated non-growing patients with Class II malocclusion, treated with mandibular propulsion appliances; outcomes were assessed before and after treatment.

Data collection and analysis
Data were extracted by two independent examiners in duplicate. The ROBINS-I tool was used to assess the methodological quality of the included studies.

Results
Of the 2824 articles identified, 11 non-randomized clinical articles were selected for qualitative analysis and 8 for quantitative analysis. SNB (0.87°, CI 95% 0.08, 1.66), ANB (−0.82°, CI 95% −1.24 to 0.40) and Pg/OLp [2.3 to 1.2 mm (P &lt; 0.001)] presented smallest but significant mandibular changes with some differences regarding the used appliance. The Herbst appliance showed the largest mandibular changes followed by the SUS appliance when evaluated through Ar-Pg. SNA showed non-significant changes. Overbite (−2.85. CI 95% −3.06, −2.64), Overjet (−5.00.CI 95% −5.45, −4.55) showed significant changes in all devices. Class II correction occurs through a significant labial movement of the mandibular incisors, some lingual inclination of the maxillary incisors and minor skeletal changes.

Conclusions
All mandibular propulsion appliances examined, showed efficiency in normalizing the Class II malocclusion in adult patients; however, changes were acquired mainly through dentoalveolar changes. Some minor mandibular forward changes was noted, mainly in patients treated with the Herbst appliance. Randomized clinical trials are needed to improve scientific evidence.

Registration
PROSPERO (code CRD42017067384).
Correcting wavefield gradients for the effects of local small-scale heterogeneities
Authors: Singh Sneha , Capdeville Yann , Igel Heiner 
Published: October 2019

Summary
Local small-scale heterogeneities, like geological inhomogeneities, surface topographies and cavities are known to affect seismic wavefield gradients. This effect is in fact measurable with current instruments. For example, the agreement between data and synthetics computed in a tomographic model is often not as good for rotation as it is for displacement. Here, we use the theory of homogenization to explain why small-scale heterogeneities strongly affect wavefield gradients, but not the wavefield itself. We show that at any receiver measuring wavefield gradient, small-scale heterogeneities cause the wavefield gradient to couple with strain through a coupling tensor J. Furthermore, we show that this J is (1) independent of source, (2) independent of time, but (3) only dependent on the receiver location. Consequently, we can invert for J based on an effective model for which synthetics fit displacement data reasonably well. Once inverted, J can be used to correct rotations at that receiver for other sources. Results of the correction are shown for synthetic rotational receivers and for the ring laser located in Wettzell, Germany. We find that compared to synthetics, the synthetics corrected through J are a better fit to the rotation data. Although results here are derived for rotations, they can be extended to receivers measuring any wavefield gradient.