bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving clinic utilization and workload capture for clinical pharmacy specialists
Authors: Steen Allison , Bovio Franck Jessica 
Published: February 2020

AbstractPurposeTo assess a quality improvement initiative aimed at improving clinic utilization and encounter and intervention workload capture for clinical pharmacy specialists. This initiative aided in justification of clinical pharmacy services, identification of clinical areas for intervention, and incorporation of all modalities to appropriately document clinical care.MethodsIn order to objectively demonstrate clinical pharmacy service value to stakeholders, pharmacy administrators and clinical pharmacy specialists at the North Florida/South Georgia Veterans Health System performed clinic scheduling and profile reviews using data extracted from the Veterans Health Administration electronic health record and analytic software. Outpatient clinical pharmacy specialty practice areas were primarily investigated; the specialty areas included are as follows: cardiology, infectious disease, mental health, oncology, pain management/palliative care, and specialty clinics (a collection of medical and surgical subspecialties). The first intervention entailed completing a worksheet and assessing clinic utilization data. Then, an evaluation was performed to assess the number of encounters, clinical interventions, clinic modalities, and coding for each clinic. Next, a meeting was arranged with each like clinical pharmacy specialist practice group to discuss this collected data. During these meetings, the delineation of where workload was generated and the activities taking place in an average workday were discussed. Finally, clinics were adjusted to reflect appropriate clinic coding and mapping of the average workday. Metrics were evaluated pre intervention (October through December 2017) and post intervention (July through September 2018).ResultsAfter intervention, there were statistically significant increases in clinic utilization, total encounters completed, and total interventions recorded in the composite group of clinical pharmacy specialists.ConclusionThe increases in clinic utilization, total encounters, and interventions observed for the clinical pharmacy specialists suggest the beneficial role of pharmacy administrators’ collaboration with clinical pharmacy specialists to improve workload capture and access to quality care, to justify clinical pharmacy services, and to identify opportunities for pharmacy clinical intervention.
Drug repositioning by prediction of drug’s anatomical therapeutic chemical code via network-based inference approaches
Authors: Peng Yayuan , Wang Manjiong , Xu Yixiang , Wu Zengrui , Wang Jiye , Zhang Chao , Liu Guixia , Li Weihua , Li Jian , Tang Yun 
Published: February 2020

Abstract
Drug discovery and development is a time-consuming and costly process. Therefore, drug repositioning has become an effective approach to address the issues by identifying new therapeutic or pharmacological actions for existing drugs. The drug’s anatomical therapeutic chemical (ATC) code is a hierarchical classification system categorized as five levels according to the organs or systems that drugs act and the pharmacology, therapeutic and chemical properties of drugs. The 2nd-, 3rd- and 4th-level ATC codes reserved the therapeutic and pharmacological information of drugs. With the hypothesis that drugs with similar structures or targets would possess similar ATC codes, we exploited a network-based approach to predict the 2nd-, 3rd- and 4th-level ATC codes by constructing substructure drug-ATC (SD-ATC), target drug-ATC (TD-ATC) and Substructure&Target drug-ATC (STD-ATC) networks. After 10-fold cross validation and two external validations, the STD-ATC models outperformed the SD-ATC and TD-ATC ones. Furthermore, with KR as fingerprint, the STD-ATC model was identified as the optimal model with AUC values at 0.899 ± 0.015, 0.916 and 0.893 for 10-fold cross validation, external validation set 1 and external validation set 2, respectively. To illustrate the predictive capability of the STD-ATC model with KR fingerprint, as a case study, we predicted 25 FDA-approved drugs (22 drugs were actually purchased) to have potential activities on heart failure using that model. Experiments in vitro confirmed that 8 of the 22 old drugs have shown mild to potent cardioprotective activities on both hypoxia model and oxygen–glucose deprivation model, which demonstrated that our STD-ATC prediction model would be an effective tool for drug repositioning.
Toward Intersectional Ecofeminist Communication Studies
Authors: Singer Norie Ross 
Published: February 2020

AbstractAfter many years of sluggish engagement between environmental and feminist communication studies, scholarship in this area is gaining momentum. Ecofeminist theory informs much of the literature at this nexus. Yet what makes ecofeminist communication research timely and uniquely important within the discipline, and what core principles guide or should guide it, have not been adequately addressed. This essay covers these questions and advocates for intersectional ecofeminist communication approaches.
Interactions Between the Aging Gut Microbiome and Common Geriatric Giants: Polypharmacy, Frailty, and Dementia
Authors: Gemikonakli Gizem , Mach John , Hilmer Sarah Nicole 
Published: February 2020

AbstractThe gut microbiome has pervasive bidirectional relationships with pharmacotherapy, chronic disease, and physical and cognitive function. We conducted a narrative review of the current literature to examine the relationships between the gut microbiome, medication use, sarcopenia and frailty, and cognitive impairment. Data from in vitro experiments, in vivo experiments in invertebrates and complex organisms, and humans indicate associations between the gut microbiome and geriatric syndromes. Better understanding of the direct and indirect roles of the microbiome may inform future prevention and management of geriatric syndromes.
Deletion of PPARγ in Mesenchymal Lineage Cells Protects Against Aging-Induced Cortical Bone Loss in Mice
Authors: Cao Jay , Ding Kehong , Pan Guodong , Rosario Raysa , Su Yun , Bao Yonggang , Zhou Hongyan , Xu Jianru , McGee Lawrence Meghan E , Hamrick Mark W , Isales Carlos M , Shi Xingming 
Published: February 2020

AbstractBone loss in aging is linked with chronic low-grade inflammation and the accumulation of marrowfat in animals and humans. Peroxisome proliferator-activated receptor gamma (PPARγ), an adipogenic regulator, plays key roles in these biological processes. However, studies of the roles of PPARγ in age-related bone loss and inflammation are lacking. We hypothesized that deletion of PPARγ in bone marrow mesenchymal lineage cells would reduce bone loss with aging, potentially through a reduction in fat-generated inflammatory responses and an increase in osteoblastic activity. In the present study, we show that mice deficient of PPARγ in Dermo1-expressing mesenchymal lineage cells (Dermo1-Cre:PPARγ fl/fl) have reduced fat mass and increased cortical bone thickness but that deficiency of PPARγ had limited effect on protection of trabecular bone with aging as demonstrated by dual-energy X-ray absorptiometry, µCT, and histomorphometric analyses. Conditional knockout of PPARγ reduced serum concentrations of adipokines, including adiponectin, resistin, and leptin, and reduced marrow stromal cell expression levels of inflammation-related genes. Inflammation genes involved in the interferon signaling pathway were reduced the most. These results demonstrate that disruption of the master adipogenic regulator, PPARγ, has a certain protective effect on aging-induced bone loss, suggesting that regulation of adipose function and modulation of interferon signaling are among the key mechanisms by which PPARγ regulates bone homeostasis during aging process.
Exploring Dementia Care Systems Across the African Caribbean Diaspora: A Scoping Review and Consultation Exercise
Authors: Lasrado Reena , Baker Sophie , Zubair Maria , Kaiser Polly , Lasrado Veena Janith , Rizzo Matilda , Govia Ishtar , Edge Dawn 
Published: February 2020

Abstract

Background and Objectives
Understanding the influences of marginalized cultural and social identities as experienced by the African Caribbean diaspora within the context of dementia care is essential to minimize the gaps in current practice and policy in the health care setting. This study explores the impact of marginalized identities upon the meaning-making process, access to services and experience of care provisions through a scoping review and consultancy exercises with key stakeholders.

Research Design
Fourteen databases were searched using key terms. Primary studies in English, any year, study design, and country of origin were eligible. Titles, abstracts, and full texts were screened for inclusion and data were extracted in stages. Thematic analysis was performed and the findings were discussed in a series of consultation meetings with people with dementia, carers, and health care professionals in Manchester (United Kingdom) and Jamaica.

Results
The scoping review retrieved n = 1,989 research articles. Nineteen were included, most were qualitative (n = 14), 3 quantitative, and 2 mixed-method. The findings revealed limited insight into cultural and multiple individual identities in explaining conceptualization and service access. Consultation meetings confirmed these findings and highlighted differences in health care services and systems in the United Kingdom and Jamaica.

Discussion and Implications
This study suggests there is a complex interaction of sociocultural processes that marginalize African Caribbean persons in and across various national settings within the context of dementia care. The study highlights the importance of acknowledging and addressing how prevalent racialized- and class-based divides and related marginalized social locations are reflected in inequities in access to and use of dementia services.
A Familial Cluster of Infection Associated With the 2019 Novel Coronavirus Indicating Possible Person-to-Person Transmission During the Incubation Period
Authors: Yu Ping , Zhu Jiang , Zhang Zhengdong , Han Yingjun 
Published: February 2020

Abstract
An ongoing outbreak of pneumonia associated with 2019 novel coronavirus was reported in China. It is unclear whether the virus is infective exists during the incubation period, although person-to-person transmission has been reported elsewhere. We report the epidemiological features of a familial cluster of 4 patients in Shanghai, including an 88-year-old man with limited mobility who was exposed only to asymptomatic family members whose symptoms developed later. The epidemiological evidence has shown possible transmission of 2019 novel coronavirus during the incubation period.
It’s time to step it up. Why safety investigations in healthcare should look more to safety science
Authors: Wiig Siri , Braithwaite Jeffrey , Clay-Williams Robyn 
Published: February 2020

AbstractAccident models and theoretical foundations underpinning safety investigations are key to understanding how investigators construct causality and make recommendations. Safety science has devoted large efforts to investigating and theorizing about accidents. Why doesn’t healthcare pay more interest to these theories when investigating healthcare accidents? We use established accident theories to suggest how these can support safety investigations in healthcare and provide new lenses to investigatory bodies. We reflect on examples from research and practice in healthcare systems and other high-risk industries. Investigation processes and reports serve multiple purposes. We argue there is an untapped improvement potential for healthcare safety investigations and suggest new ways of integrating different accident theoretical reflections with investigatory practice.
This Time It's Personal
Authors: Runciman Brian 
Published: February 2020

Abstract
Is everyone talking ethics in IT right now? Combinations of anger, worry and helplessness are surely not the feelings computing wants to generate. But in 2020, there are justifiable fears about technology and plenty of misunderstanding about what it can and can't do. This year, BCS is focusing its research and main conference on what personal responsibility means in IT. Brian Runciman MBCS writes.
BCS ICT Conference UAE 2019
Authors: Al Hashmi Adel Salam Alkaff 
Published: February 2020

Abstract
Under the patronage of HE Shaikh Nahyan bin Mubarak Al Nahyan, Minister of Tolerance, the BCS ICT Conference 2019 was launched, at the Anantara Eastern Mangroves Hotel, Abu Dhabi on 27th Oct under the theme: ‘Tolerance, Sustainability & Women's Empowerment’.
Determination of Ethanol in Wine by Chemical Oxidation: 1969 Studies
Authors: Caputi Arthur 
Published: February 2020

Abstract
The micro dichromate procedure for ethanol in wine was subjected to a successful collaborative study in 1968 and adopted as official first action. In 1969 all analyses using this method were run in duplicate at the Gallo laboratories and results for a number of different wine types were selected at random and tabulated. From 23 to 34 sets of duplicate determinations were evaluated for 14 different wine types. Average alcohols ranged from 11.55 to 23.47% and standard deviations varied from 0.039 to 0.070%. Nine different analysts participated in the study and no one analyst performed both determinations on a given sample. In view of the fact that these results correspond very closely to those obtained in the 1968 collaborative study and that many members of the wine industry are now successfully using this method, it is recommended that the method be adopted as official final action.
GLC Determination of the Optical Isomers of Amphetamine
Authors: Wells Clyde E 
Published: February 2020

Abstract
A method is described for the quantitative determination of the ratio of d- and l-amphetamine stereoisomers by GLC. A derivative formed with N-trifluoroacetyl-(l)-prolyl chloride is chromatographed and the isomeric ratio is read from a standard calibration curve. The method is applicable to crystalline salts of amphetamine and to commercial tablet dosage forms. It is recommended that this method be subjected to collaborative study.
Fluorometric Determination of Quinacrine Hydrochloride in Drug Preparations: Collaborative Study
Authors: Roberts Laura A 
Published: February 2020

Abstract
A fluorometric method has been developed for the quantitative and qualitative determination of quinacrine hydrochloride in drug preparations. The method consists of a preliminary dispersion of the sample in dilute HCl, filtration if necessary, appropriate dilutions of the sample to a final concentration of 0.5 μg quinacrine.HCl/ml in 0.1N HCl, and finally, measurement of its fluorescence on a suitable spectrophotofluorometer. Nine collaborators obtained 100-102% recovery of quinacrine.HCl and the fluorometric determination of quinacrine. HCl is recommended as official first action.
Separation and Determination of Trace Amounts of Tin Present as Organotin Residues on Fruits
Authors: Corbin Homer B 
Published: February 2020

Abstract
The dithiol colorimetric method has been applied to the determination of trace amounts of tin as residues from the spray treatment of fruit with a miticide containing tricyclohexyltin hydroxide. The samples are prepared by an initial wet combustion to give a sulfuric acid solution of tin in the inorganic form. The tin is separated from other elements in the acid digest by one of two methods. One involves distillation of stannic bromide with a mixture of HBr and HCl. In the second separation method stannic iodide is extracted into n-hexane. Both separation procedures result in a solution of tin in a few milliliters of concentrated H2SO4, which is then measured spectrophotometrically. Data are presented for sensitivity and precision of the measuring system; accuracy and precision of both separation methods are illustrated by duplicate analyses and recovery tests on apples and pears treated with various cyclohexyltin compounds and inorganic tin. The extraction method has been tested for compatibility with 35 elements. Only arsenic (&gt;0.15 mg or 1.5 ppm) and antimony (&gt;2 mg or 20 ppm) are likely to interfere. Procedures are given for elimination of greater amounts of these elements.
The High Resolution NMR Spectra of Pesticides. III. The Carbamates
Authors: Keith L H , Alford A L 
Published: February 2020

Abstract
The high resolution nuclear magnetic resonance spectra of 35 carbamate pesticides and a major metabolite of one pesticide are discussed. The chemical shifts and coupling constants are tabulated and reproductions of the more complex or unusual spectra are included. A concentration and solvent dependence of both the NH-proton and the NCH3-proton resonances of an N-monosubstituted carbamate is discussed. Hindered rotation is observed in the N,N-dimethylcarbamates, the thiolcarbamates and the dithiocarbamates, but not in the N-methylcarbamates.
Xanthophylls and Carotenes in Feeds and Feed Materials: Collaborative Study
Authors: Quackenbush F W 
Published: February 2020

Abstract
Eight laboratories showed satisfactory agreement in analysis of three pairs of samples (corn gluten, alfalfa meal, and mixed feed) by a proposed method for xanthophylls and carotenes. The method permits separation of monohydroxy pigments from dihydroxy pigments and excludes the non-pigmenting (avian) polyoxy pigments. It is recommended for adoption as official first action.
Collaborative Study of a Rapid Electrophoretic Method for Fish Species Identification. II. Authentic Flesh Standards
Authors: Learson Robert J 
Published: February 2020

Abstract
The cellulose acetate method of fish species identification was collaboratively studied a second time, using authentic flesh samples as standards. Eleven collaborators were asked to identify ten unknown fish samples from a set of nine standard flesh samples. The collaborators identified the unknown samples with 91% accuracy. It is recommended that the method be adopted as official first action.
Collaborative Study on the GLC Determination of Propylene Glycol in Cosmetics
Authors: Margaree H. Champion 
Published: February 2020

Abstract
A method for the determination of propylene glycol in cosmetics by GLC, using Chromosorb 101 as a column packing, was submitted to collaborative study. Four samples were analyzed at two levels of concentration. Results for the six collaborators show recoveries of 95-108% for samples containing from 20.0 to 40.0 mg propylene glycol. The standard deviation varied from 0.54 to 1.67 and the coefficient of variance from 2.8 to 4.7%. It is recommended that the method be adopted as official first action.
Effect of Moisture and Incubation Time on Ochratoxin A Production by an Isolate of Aspergillus ochraceus
Authors: Schindler A F , Nesheim Stanley 
Published: February 2020

Abstract
Experiments were conducted to determine the culture requirements that would insure a probability of high ochratoxin production with a given isolate. Experiments at ambient temperatures (72 ± 2°F) determined the levels of the two most readily controlled variables, time and moisture content, during the growth of a high toxin-producing isolate (M298) of Aspergillus ochraceus. Tests were conducted in 2.8 L - Fernbach flasks containing 100 g shredded wheat and inoculated with spores on a transfer needle. Amounts of ochratoxin A/flask were determined by comparison against standards on TLC after chloroform extraction. Statistical analysis showed a relation between ochratoxin yield, water levels, and incubation periods. A water level of 40–70 ml/flask with an incubation period of 19-21 days at ambient temperatures should give a near to maximum yield of ochratoxin A.
Drained Weight Determination of Frozen Alaska King Crabmeat
Authors: Miller George A 
Published: February 2020

Abstract
A limited collaborative study is presented which evaluated two methods for drained weight of Alaska king crabmeat: the Alaska King Crab Marketing and Control Board method and the Werren-Weik drained weight method for shrimp. One variable concerning the effect of added flood water and surface glazing of frozen cut units was studied by both methods. Four collaborators, two performing determinations according to each method, reported average recovered drained crabmeat in close agreement with results reported previously. Both methods are recommended for adoption as official first action for frozen glazed Alaska king crabmeat.
Application of Atomic Absorption Spectroscopy to Pharmaceutical Analysis
Authors: Leaton J R 
Published: February 2020

Abstract
Procedures are described for analysis of minerals and element-containing drugs in various pharmaceutical preparations by atomic absorption spectroscopy. Sample preparation of liquids, powders, tablets, and ointments is reduced to a minimum by employing the technique of acid-dissolution and a releasing agent of lanthanum chloride. There are little or no elemental interferences or losses as shown by high recoveries and low standard deviations. Recoveries from commercial preparations ranged from 94 to 106% of theory or declared amount. Guidelines and operating instrumental conditions are given.
Absorptivity and Solid State and Solution Fluorescence of Mixed Aflatoxin Standards Stored in Solution and as Dry Films
Authors: Pons W A , Robertson J A , Cucullu A F , Goldblatt L A 
Published: February 2020

Abstract
Mixed anatoxin B1, B2, G1, and G2 standards were stored 1 year in chloroform and benzene solutions and as dry films at 28 and – 18°C. Weighted average molar absorptivity and solution and TLC plate fluorescence were used as indices of deterioration. Changes in all three indices were greater for standards stored at 28°C than for those stored at –18°C. Storage at 28°C resulted in appreciable deterioration of dry film standards. Both solution and plate fluorescence were more sensitive indices than molar absorptivity for detecting changes in the properties of stored standards. A good correlation was obtained between anatoxin concentration as measured by UV molar absorptivity and the plate fluorescence of the stored standards. An accelerated storage study of anatoxins B1 and G1 stored 34 days in benzeneacetonitrile (98 + 2) at 51°C showed no detectable change in molar absorptivity or plate fluorescence.
Rapid Colorimetric Method for Estimation of Thiram Residues on Grains
Authors: Rangaswamy J R , Poornima P , Majumder S K 
Published: February 2020

Abstract
A rapid and relatively simple method has been developed for the colorimetric determination of thiram residues on grains. Cuprous chloride is used to form a yellow complex with thiram, which is measured at 420 nm. The method is satisfactory for analyses of 4–200 Mg thiram.
GLC Determination of Hexachlorophene in Several Agricultural Samples
Authors: Gutenmann W H , Lisk D J 
Published: February 2020

Abstract
A method is described for analysis of the fungicide hexachlorophene in agricultural samples after cleanup on a Celite-H2S04 column. It is based on electron affinity gas chromatography of the methyl ether and is sensitive to about 0.02 ppm of the fungicide. The procedure has been applied to analysis of hexachlorophene in tomatoes, sweet corn, cucumbers, and milk.
Microbiological Assay of Vitamin He and Its Components
Authors: Toepfer Edward W , Polansky Marilyn M 
Published: February 2020

Abstract
Nine collaborators studied a method for determining vitamin B6 and pyridoxine, pyridoxal, and pyridoxamine in foods and like materials. The 3 vitamin B6 components in food extracts were eluted in separate fractions from an ion exchange column and determined separately by microbiological assay, using the yeast S. carlsbergensis as the test organism. It is recommended that the method be adopted as official first action.