bluuebunny/crossref_metadata_2025_split huggingface dataset:
Various Diseases and Clinical Heterogeneity Are Associated With “Hot Cross Bun”
Authors: Zhu Shuzhen , Li Hualing , Deng Bin , Zheng Jialing , Huang Zifeng , Chang Zihan , Huang Yanjun , Wen Zhibo , Liang Yanran , Yu Mengjue , Chan Ling-Ling , Tan Eng-King , Wang Qing 
Published: November 2020

Objective: To characterize the clinical phenotypes associated with the “hot cross bun” sign (HCBs) on MRI and identify correlations between neuroimaging and clinical characteristics.Methods: Firstly, we screened a cohort of patients with HCBs from our radiologic information system (RIS) in our center. Secondly, we systematically reviewed published cases on HCBs and classified all these cases according to their etiologies. Finally, we characterized all HCBs cases in detail and classified the disease spectra and their clinical heterogeneity.Results: Out of a total of 3,546 patients who were screened, we identified 40 patients with HCBs imaging sign in our cohort; systemic literature review identified 39 cases, which were associated with 14 diseases. In our cohort, inflammation [neuromyelitis optica spectrum disorders (NMOSD), multiple sclerosis (MS), and acute disseminated encephalomyelitis (ADEM)] and toxicants [toxic encephalopathy caused by phenytoin sodium (TEPS)] were some of the underlying etiologies. Published cases by systemic literature review were linked to metabolic abnormality, degeneration, neoplasm, infection, and stroke. We demonstrated that the clinical phenotype, neuroimaging characteristics, and HCBs response to therapy varied greatly depending on underlying etiologies.Conclusion: This is the first to report HCBs spectra in inflammatory and toxication diseases. Our study and systemic literature review demonstrated that the underpinning disease spectrum may be broader than previously recognized.
Long Non-coding RNA Expression Profiling Identifies a Four-Long Non-coding RNA Prognostic Signature for Isocitrate Dehydrogenase Mutant Glioma
Authors: Chen Yusheng , Guo Yang , Chen Hang , Ma Fengjin 
Published: November 2020

Background: Isocitrate dehydrogenase (IDH) mutant is one of the most robust and important genetic aberrations in glioma. However, the underlying regulation mechanism of long non-coding RNA (lncRNA) in IDH mutant glioma has not been systematically portrayed.Methods:In this work, 775 IDH mutant glioma samples with transcriptome data, including 167 samples from the Chinese Glioma Genome Atlas (CGGA) RNAseq dataset, 390 samples from The Cancer Genome Atlas (TCGA) dataset, 79 samples from GSE16011 dataset, and 139 samples from CGGA microarray dataset, were enrolled. R language and GraphPad Prism software were applied for the statistical analysis and graphical work.Results: By comparing the differentially lncRNA genes between IDH mutant and IDH wild-type glioma samples, a four-lncRNA (JAG1, PVT1, H19, and HAR1A) signature was identified in IDH mutant glioma patients. The signature model was established based on the expression level and the regression coefficient of the four lncRNA genes. IDH mutant glioma samples could be successfully stratified into low-risk and high-risk groups in CGGA RNAseq, TCGA, GSE16011, and CGGA microarray databases. Meanwhile, multivariate Cox analysis showed that the four-lncRNA signature was an independent prognostic biomarker after adjusting for other clinicopathologic factors. Moreover, the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses revealed that the immune response and cellular metabolism were significantly associated with the four-lncRNA risk signature.Conclusion: Taken together, the four-lncRNA risk signature was identified as a novel prognostic marker for IDH mutant glioma patients and may potentially lead to improvements in the lives of glioma patients.
Identifying Training, Diagnostic and Therapeutic Needs From a Comparison in the Distribution of Vestibular Disorders in Primary Care and in a Neurotology Unit
Authors: Domínguez-Durán Emilio , Moreno-de-Jesús Carolina , Prieto-Sánchez-de-Puerta Lucía , Mármol-Szombathy Irene , Sánchez-Gómez Serafín 
Published: November 2020

Introduction: Several epidemiological studies in Neurotology have been previously carried out in the general population. This approach is useful for learning about the most common disorders in clinical population, but it may fail when one is trying to help professionals to guide their training, to optimize their resources and to decide on the highest-priority research objectives.Objective: To identify which of the neurotological diseases are most common in two different populations, those who attended a consultation in the Neurotology Unit of a tertiary level hospital and those who did so in Primary Care in order to infer which of them requires more attention in each context and their specific needs.Methods: All the diagnoses made in Hospital Care between October 15, 2017 and October 14, 2018 were reviewed. These diagnoses were coded and classified into syndromes and diseases. Later, the proportions of each category were compared with the proportions of the neurotological diagnoses made in five Primary Care centers over the same period of time.Results: BPPV is the most common cause of vestibular symptoms in both contexts. Vestibular migraine, ischemic vestibular symptoms, orthostatic hypotension and side effects of drugs are common in Primary Care, whereas Ménière's disease and undifferentiated episodic vestibular syndrome are common in specialized centers.Conclusion: The proportion of diagnoses in neurotologic patients is different in the general population and in the specialized center population, and therefore they have different needs. Primary Care professionals would benefit from training on maneuvers for repositioning otoliths, the treatment of headache, the identification of cardiovascular risk factors, the orthostatic hypotension and the side effects of the most commonly used drugs. The professionals who work in specialized centers need strategies for dealing with cases of BPPV associated to other vestibular diseases and refractory cases and their research should focus on the development of new diagnostic tools for the diagnosis of undifferentiated episodic vestibular syndrome and new therapeutic options for Ménière's disease.
Comparative Assessment of the WNT/β-Catenin Pathway, CacyBP/SIP, and the Immunoproteasome Subunit LMP7 in Various Histological Types of Renal Cell Carcinoma
Authors: Piotrowska Żaneta , Niezgoda Michał , Młynarczyk Grzegorz , Acewicz Magdalena , Kasacka Irena 
Published: November 2020

ObjectiveThe Wnt/ß-catenin pathway plays an important role in pathogenesis of variety cancers. Most studies on changes in WNT/β-catenin pathway in renal cell carcinoma (RCC) apply only to clear cell RCC, while there are no comparative assessments of this signaling pathway in various histological types of renal tumors in the available literature. Additionally, considering the close relationship between WNT/β-catenin signaling, CacyBP/SIP and proteasomal activity, it seemed worth comparing WNT/β-catenin pathway, CacyBP/SIP and LMP7 immunoproteasome subunit in human samples of clear cell, papillary, and chromophobe RCC.MethodsTests were performed on sections of three types of kidney tumors together with surrounding unchanged tissue fragments collected from 50 patients. Samples were divided into three groups depending on the histological type of cancer: clear cell, papillary and chromophobe RCC. Immunohistochemistry and PCR methods were used to identify WNT10A, Fzd5, β-catenin, GSK-3ß, CacyBP/SIP, LMP7, and gene expression.ResultsImmunoreactivity and expression of WNT10A, Fzd5, β-catenin, GSK-3ß, CacyBP/SIP, LMP7 in clear cell RCC was markedly increased compared to non-cancerous kidney tissue. In papillary RCC, immunoreactivity and expression of WNT/β-catenin pathway, CacyBP/SIP, LMP7 was also increased compared to non-malignant kidneys, but it was less pronounced than in clear cell RCC. The least substantial increase in immunoreactivity and expression of WNT/β-catenin pathway, CacyBP/SIP, LMP7 was found in chromophobe RCC, compared to other RCC histological subtypes studied.ConclusionsStudy results suggest an important role of WNT/β-catenin pathway, CacyBP/SIP and LMP7 in RCC carcinogenesis, and may indicate new aspects of pathomechanisms leading to differences in the biology of clear cell, papillary and chromophobe RCC.
Cancer History and Systemic Anti-Cancer Therapy Independently Predict COVID-19 Mortality: A UK Tertiary Hospital Experience
Authors: Sng Christopher C. T. , Wong Yien Ning Sophia , Wu Anjui , Ottaviani Diego , Chopra Neha , Galazi Myria , Benafif Sarah , Soosaipillai Gehan , Roylance Rebecca , Lee Alvin J. X. , Shaw Heather 
Published: November 2020

BackgroundThe COVID-19 pandemic remains a pressing concern to patients with cancer as countries enter the second peak of the pandemic and beyond. It remains unclear whether cancer and its treatment contribute an independent risk for mortality in COVID-19.MethodsWe included patients at a London tertiary hospital with laboratory confirmed SARS-CoV-2 infection. All patients with a history of solid cancer were included. Age- and sex-matched patients without cancer were randomly selected. Patients with hematological malignancies were excluded.ResultsWe identified 94 patients with cancer, matched to 226 patients without cancer. After adjusting for age, ethnicity, and co-morbidities, patients with cancer had increased mortality following COVID-19 (HR 1.57, 95% CI:1.04–2.4, p = 0.03). Increasing age (HR 1.49 every 10 years, 95% CI:1.25–1.8, p &lt; 0.001), South Asian ethnicity (HR 2.92, 95% CI:1.73–4.9, p &lt; 0.001), and cerebrovascular disease (HR 1.93, 95% CI:1.18–3.2, p = 0.008) also predicted mortality. Within the cancer cohort, systemic anti-cancer therapy (SACT) within 60 days of COVID-19 diagnosis was an independent risk factor for mortality (HR 2.30, 95% CI: 1.16–4.6, p = 0.02).ConclusionsAlong with known risk factors, cancer and SACT confer an independent risk for mortality following COVID-19. Further studies are needed to understand the socio-economic influences and pathophysiology of these associations.
Aspirin Eugenol Ester Protects Vascular Endothelium From Oxidative Injury by the Apoptosis Signal Regulating Kinase-1 Pathway
Authors: Huang Mei-Zhou , Zhang Zhen-Dong , Yang Ya-Jun , Liu Xi-Wang , Qin Zhe , Li Jian-Yong 
Published: November 2020

Aspirin eugenol ester (AEE) is a new potential pharmaceutical compound possessing anti-inflammatory, anti-cardiovascular disease, and antioxidative stress activity. The pharmacological activities of AEE are partly dependent on its regulation of cell apoptosis. However, it is still unclear how AEE inhibits cell apoptosis on the basis of its antioxidative stress effect. This study aimed to reveal the vascular antioxidative mechanism of AEE in response to H2O2-induced oxidative stress in HUVECs and paraquat-induced oxidative stress in rats. In the different intervention groups of HUVECs and rats, the expression of ASK1, ERK1/2, SAPK/JNK, and p38 and the phosphorylation levels of ERK1/2, SAPK/JNK, and p38 were measured. The effects of ASK1 and ERK1/2 on the anti-apoptotic activity of AEE in the oxidative stress model were probed using the corresponding inhibitors ASK1 and ERK1/2. The results showed that in the HUVECs, 200 μM H2O2 treatment significantly increased the phosphorylation of SAPK/JNK and the level of ASK1 but decreased the phosphorylation of ERK1/2, while in the HUVECs pretreated with AEE, the H2O2-induced changes were significantly ameliorated. The findings were observed in vitro and in vivo. Moreover, inhibition of ASK1 and ERK1/2 showed that ASK1 plays a vital role in the protective effect of AEE on H2O2-induced apoptosis. All findings suggested that AEE protects the vascular endothelium from oxidative injury by mediating the ASK1 pathway.
Association of Physical Fitness Performance Tests and Anthropometric Indices in Taiwanese Adults
Authors: Chen Po-Hung , Chen Wei , Wang Cheng-Wei , Yang Hui-Fei , Huang Wan-Ting , Huang Hsiu-Chen , Chou Che-Yi 
Published: November 2020

BackgroundThe association between physical fitness performance tests and anthropometric indices is not clear. The study aims to explore the association between physical fitness performance and anthropometric indices in Taiwanese community-dwelling adults. This may help in monitoring anthropometric indices to improve physical fitness.MethodsWe recruited 2216 participants aged 23–64 years between 2014 and 2017. Physical fitness performance, including abdominal muscular endurance (60-s sit-up test), flexibility (sit-and-reach test), and cardiorespiratory endurance (3-min step test), was evaluated in all participants. The association of the physical fitness performance and anthropometric indices, including body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR), was analyzed using linear regression, with adjustments for age and gender.ResultsBody mass index was negatively associated with abdominal muscular endurance (p &lt; 0.001) and cardiorespiratory endurance (p &lt; 0.001). Neither BMI, WC, WHR, nor WHtR were significantly associated with flexibility. Abdominal muscle endurance, flexibility, and cardiorespiratory endurance were significantly lower in obese participants when obesity was defined using a BMI of ≥27, 30, and 35 kg/m2. Participants with central obesity that was defined as WC ≥ 90 cm in men and 80 cm in women and WHtR ≥ 0.6 had lower abdominal muscular endurance than those without central obesity.ConclusionBody mass index is associated with abdominal muscular endurance and cardiorespiratory endurance in a reverse J-shaped manner. None of the anthropometric indices are significantly associated with flexibility. Obesity defined by BMI is linked to worse physical fitness performance and obesity defined using WHtR is linked to lower abdominal muscular endurance in Taiwanese community-dwelling adults.
Gender Difference in the Prevalence of Insomnia: A Meta-Analysis of Observational Studies
Authors: Zeng Liang-Nan , Zong Qian-Qian , Yang Yuan , Zhang Ling , Xiang Yi-Fan , Ng Chee H. , Chen Li-Gang , Xiang Yu-Tao 
Published: November 2020

Objective: Insomnia is a major health challenge in the general population, but the results of the gender differences in the epidemiology of insomnia have been mixed. This is a meta-analysis to examine the gender difference in the prevalence of insomnia among the general population.Methods:Two reviewers independently searched relevant publications in PubMed, EMBASE, PsycINFO, Web of Science from their inception to 16 April 2019. Studies that reported the gender-based prevalence of insomnia according to the international diagnostic criteria were included for analyses using the random-effects model.Results:Eventually 13 articles were included in the meta-analysis. The pooled prevalence of insomnia in the general population was 22.0% [n = 22,980, 95% confidence interval (CI): 17.0–28.0%], and females had a significantly higher prevalence of insomnia compared with males (OR = 1.58, 95% CI: 1.35, 1.85, Z = 5.63, p &lt; 0.0001). Subgroup analyses showed that greater gender difference was associated with the use of case-control study design and consecutive sampling method. Meta-regression analyses also revealed that higher proportion of females and better study quality were significantly associated with greater gender difference.Conclusions:This meta-analysis found that the prevalence of insomnia in females was significantly higher than males in the included studies. Due to the negative effects of insomnia on health, regular screening, and effective interventions should be implemented in the general population particularly for females.
ANALISA PEMANFAATAN MULTIPROTOCOL LABEL SWITCHING PADA ROUTING PROTOCOL OPEN SHORTEST PATH FIRST
Authors: Friyanto Angga , Bachtiar Adam Mukharil , Baihaqi Abdu Sofyan 
Published: November 2020

Transformasi digital diberbagai sektor membuat peningkatan kebutuhan infrastruktur jaringan untuk menopang tingginya trafik. Ketersedian sumber daya jaringan menjadi komponen penting dalam proses bisnis pada era digital. Selain penambahan infrastruktur, solusi yang dapat dilakukan untuk memenuhi kebutuhan tersebut adalah optimasi. OSPF (Open Shortest Path First) sebagai salah satu mekanisme penentuan jalur pengiriman data secara dinamis memiliki fitur dan performa yang baik dengan kalkulasi secara otomatis menggunakan algoritma yang memperhitungkan lebar bandwith. Dalam transmisi data, MPLS (Multiprotocol Label Switching) merupakan metode pengiriman paket data menggunakan label dalam proses penerusan pengiriman paket data. Penelitian ini menganalisis optimalisasi pemanfaatan MPLS sebagai mekanisme pengiriman paket data untuk komunikasi protokol routing OSPF. Pada penelitian ini, metode yang digunakan adalah dengan eksperimen. Analisa yang dilakukan dengan membandingkan data hasil uji coba sistem jaringan OSPF yang menggunakan MPLS dan sistem jaringan OSPF tanpa MPLS. Dari analisa yang dilakukan dengan membandingkan delay dan packet loss disimpulkan sistem jaringan yang menggunakan MPLS lebih efisien dan lebih cepat dalam komunikasi data.
Kata Kunci: Data Transmisi, MPLS, OSPF, Rekayasa Trafik, Routing
EVALUASI USER INTERFACE APLIKASI GOJEK TERHADAP PENGGUNA APLIKASI DI KOTA AMBON DENGAN METODE HEURISTIC
Authors: Tamtelahitu Trientje Marlein , Lewaharilla Nusye Mozes Y , Patty Joanna Cristy 
Published: November 2020

Pada saat ini aplikasi ojek online di Indonesia telah berkembang dan mengalami pertumbungan yang pesat. Itu terlihat dari banyaknya aplikasi ojek online yang sudah mulai memberikan layanan dan informasi melalui sebuah aplikasi terutama dengan aplikasi mobile. Melalui perkembangan ini kita dapat mengambil manfaat dari keterlibatan pengguna dalam menggunakan aplikasi ojek online yang baik, tentang kegunaan dan kredibilitas diyakini menjadi salah satu factor yang mempengaruhi keterlibatan perkembangan dan pertumbuhan itu. Salah satu ojek berbasis teknologi aplikasi ponsel yang digunakan oleh masyarakat adalah Go-Jek. Oleh karena itu, Makalah ini menyajikan studi empiris dalam mengevaluasi usability aplikasi mobile Go-jek. Pengujian perangkat lunak perlu dilakukan agar dapat diketahui apakah perangkat lunak yang dikembangkan telah memenuhi kebutuhan pengguna akhir. Hasil yang diperoleh menunjukan bahwa dengan mengetahui severity dari aplikasi tersebut, dapat digunakan untuk perbaikan pada aplikasi Go-jek.
Kata Kunci: Ambon, Aplikasi Mobile, Go-jek, Heuristic, Severity
Residência Multiprofissional
Authors: Batista Silva Letícia 
Published: November 2020

O artigo trata dos projetos em disputa na área da saúde que tem impactos efetivo nas Residências Multiprofissionais. Parte do entendimento de que as Residências Multiprofissionais em Saúde são uma modalidade de formação que se realiza através e pelo trabalho em saúde, e ocupa estratégico na qualificação dos trabalhadores para o Sistema Único de Saúde (SUS).
O Serviço Social na História
Authors: Salete Boschetti Ivanete 
Published: November 2020

O texto situa alguns elementos essenciais na trajetória do Serviço Social brasileiro desde o chamado “Congresso da Virada”, que aconteceu em 1979. Trata-se de revisitar 40 anos de história da profissão, embebida em suas determinações econômicas, políticas e sociais, partindo do contexto do regime autocrático instaurado em 1964, passando pelo contexto da democracia burguesa alcançada com a Constituição de 1988 e chegando em 2019 num contexto de avanço fascistizante, que traz à tona o ultraneoliberalismo, o obscurantismo, e o ataque à própria democracia burguesa.
Doença de Rosai-Dorfman em paciente do sexo feminino e idade atípica: relato de caso e revisão de literatura
Authors: Guedes Pires Ana Luíza , Magalhães Apolinário Matheus , Alves de Almeida Lucas , Chehuen Neto José Antônio , Campos Pereira de Assis Emílio Augusto 
Published: November 2020

Introdução: A doença de Rosai-Dorfman (DRD) é um distúrbio histiocítico proliferativo benigno raro, que normalmente se apresenta com linfadenopatia massiva, indolor, bilateral, principalmente na região cervical e submandibular, podendo vir acompanhado de febre, perda de peso, sudorese noturna, leucocitose e aumento da velocidade de hemossedimentação. A prevalência da doença é maior em homens de até 20 anos. Não há consenso quanto à etiologia da doença, apesar de acreditarem existir algumas correlações com herpes vírus humano tipo 6 (HHV6), vírus Epstein-Barr (EBV) ou citomegalovírus. Objetivo: Demonstrar entidade rara em uma apresentação atípica e verificar as condutas tomadas. Relato de Caso: MASC, feminino, 55 anos, queixava-se de massa cervical à direita com compressão há cinco meses. Ainda sem diagnóstico, foi realizada operação para retirada de provável linfonodo cervical. A peça cirúrgica foi enviada para exame anatomopatológico e imunohistoquímico, sendo diagnosticada doença de Rosai-Dorfman. Após um ano e cinco meses de pós-operatório, notou-se recidiva do caso. Resultados: Trata-se de uma paciente de 55 anos, cuja entidade torna-se ainda mais rara pelo sexo e idade acometidos, além de apresentação unilateral. Diagnóstico prévio ao ato operatório não foi possível, sendo confirmado pelas análise anatomopatológica e imunohistoquímica. Paciente apresentou recidiva, tratada com corticoterapia pela equipe clínica. Conclusão: Para minimizar situações de erro ou atraso de diagnóstico, torna-se importante o conhecimento dos principais sintomas apresentados pelos pacientes e suas possíveis variações, colocando-a sempre como diagnóstico diferencial de adenomegaliais cervicais.
Adão, Eva, Caim e Abel sem a letra 'a', por Fulgêncio, o Mitógrafo: tradução do Livro I do lipograma De aetatibus mundi et hominis
Authors: Dos Santos Júnior Cristóvão José , Amarante Santos Sobrinho José 
Published: November 2020

A presente pesquisa aborda o processo tradutório do primeiro livro (Ausente A) da obra De aetatibus mundi et hominis, creditada ao autor norte-africano e tardo-antigo Fábio Plancíades Fulgêncio. Nesta primeira seção da obra, aqui traduzida, Fulgêncio narra o mito do pecado original relativo a Adão e Eva. Ocorre que, em sua descrição, o Mitógrafo adota o mecanismo esteticamente inusitado de supressão de letras (lipograma), evitando palavras que apresentem registro em ‘a’, o que foi mantido na proposta de tradução.
Pelatihan Analisis Data Bivariat Menggunakan SPSS Bagi Dosen STIKES Mandala Waluya Kendari
Authors: Fadmi Fitri Rachmillah , Buton La Djabo 
Published: November 2020

Kegiatan pengabdian masyarakat ini dilakukan untuk meningkatkan wawasan, ilmu pengetahuan dan keterampilan para dosen STIKES Mandala Waluya Kendari dalam melakukan analisis data bivariate menggunakan program Statistical Product for Service Solution (SPSS). Peserta dalam kegiatan pengabdian ini sebanyak 15 orang dosen. Metode pelasakanaan kegiatan pengabdian diawali tahap persiapan, pelaksanaan dan evaluasi. Untuk mengukur keberhasilan pelatihan dilakukan pengukuran pre test dan post test. Hasil pelatihan menujukkan bahwa antara nilai pre test dan post test terjadi kenaikan sebesar 15,27. Hasil uji Paired Sample t test memperoleh nilai p-value < a (0.05), Artinya bahwa pelatihan berpengaruh dalam meningkatkan pemahaman peserta. Dengan demikian dapat disimpulkan bahwa kegiatan pelatihan ini cukup berhasil menambah pemahaman peserta dari wawasan, ilmu pengetahuan dan keterampilan bagi peserta pelatihan. Kegiatan pengabdian masyarakat terlaksana secara tertib dan tertib dan teratur Dosen-dosen yang hadir sebagai peserta menanggapi positif pelatihan analisis data bivariat ini.