bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Herbicidal Activities of Novel Thiazole PPO Inhibitors
Authors: Chen Shu , Ren Guihua , Pei Dan , Zhang Fan , Liu Jie , Zhang Donglin , Yang Ren , Shi Jianjun , Xu Tianming , Tan Chengxia 
Published: February 2020

Background:Protoporphyrinogen oxidase (PPO, EC 1.3.3.4) is a key enzyme in the biosynthesis of chlorophyll and heme, also the target of different types of herbicides. Thiazole compounds shown excellent biological activity, can be designed by using active groups docking for new PPO inhibitors.Objective:The objective of this study was to synthsize a series of aryl thiazole compounds as PPO inhibitors.Methods:In this study, a series of aryl thiazole compounds derivatives 11a-l were obtained from 2- chloro-5-nitrobenzoic acid as the starting material via esterification, Iron powder reduction, diazotization, Hantzsch reaction and final acylation. All synthesized compounds have been tested for their herbicidal activities as a PPO inhibitors.Results:The Petri dish test indicated that all compounds exhibited good herbicidal activities at 200 mg/L using culture dish. And the post-emergence tests showed that at 150g.ai/ha on weed stem leaf spray treatment, some of the title compounds exhibited 80% inhibition rate against the dicotyledonou weeds Amaranthus retroflexus and Eclipta prostrate.Conclusion:Good activity was noted for some compounds that compounds 11a, 11b, 11c, 11g, 11h had 80% inhibition on stems and leaves of Amaranthus retroflexus at 150g.ai/ha.
Synergy Effects of Metformin and Berberine on Glyoxal-induced Carbonyl Stress in Isolated Rat Liver Mitochondria
Authors: Rezaei Mohsen , Kalantari Heibatullah , Mehrzadi Saeed , Goudarzi Mehdi 
Published: February 2020

Objective:
Carbonyl stress, resulting from toxic effects of alpha-dicarbonyls such as
glyoxal (GO), plays an important role in mitochondrial dysfunction and subsequent development of
diabetic complications. This study evaluated the ability of metformin (MET), berberine (BBR), and
their combination to prevent GO-induced carbonyl stress in isolated rat liver mitochondria.

Methods:
Mitochondria (0.5 mg protein/mL) were isolated from the Wistar rat liver and incubated
with various concentrations of GO (1, 2.5, 5, 7.5, and 10 mM) for 30 minutes and IC50 for GO was
calculated. The suspensions of mitochondria were incubated with various concentrations of MET
(2.5, 5, 10, and 20 mM) or BBR (2.5, 5, 10, and 20 μM) for 30 min and then GO in a dose of IC50
at 37 ºC for 30 min. Mitochondrial complex II activity, mitochondrial membrane potential (MMP),
MDA level, reactive oxygen species (ROS) formation, reduced glutathione (GSH) content, and
protein carbonylation were assessed. The combination index and isobologram of MET and BBR on
GO toxicity were calculated.

Results:
IC50 of GO was assigned approximately 3 mM. GO disrupted the electron transfer chain
and significantly increased mitochondrial ROS formation, protein carbonylation, and MDA level.
GO decreased mitochondrial viability, MMP, and GSH content. Pre-treatment with MET and BBR
could potentially reverse GO-induced deleterious effects in a concentration-dependent manner.
Results of the drug combination indicated that CI for Fa 0.5 (Effect 50 %) was 0.83.

Conclusion:
These results suggest that BBR in combination with MET has a moderate synergistic
effect on GO-induced carbonyl stress in isolated rat liver mitochondria.
Pathogenic Mechanisms and Therapeutic Implication in Nickel-Induced Cell Damage
Authors: Salimi Ahmad , Jamali Zhaleh , Atashbar Saman , Khezri Saleh , Ghorbanpour Amir M. , Etefaghi Nahid 
Published: February 2020

Background:Nickel (Ni) is mostly applied in a number of industrial areas such as printing inks, welding, alloys, electronics and electrical professions. Occupational or environmental exposure to nickel may lead to cancer, allergy reaction, nephrotoxicity, hepatotoxicity, neurotoxicity, as well as cell damage, apoptosis and oxidative stress.Methods:In here, we focused on published studies about cell death, carcinogenicity, allergy reactions and neurotoxicity, and promising agents for the prevention and treatment of the toxicity by Ni.Results:Our review showed that in the last few years, more researches have focused on reactive oxygen species formation, oxidative stress, DNA damages, apoptosis, interaction with involving receptors in allergy and mitochondrial damages in neuron induced by Ni.Conclusion:The collected data in this paper provide useful information about the main toxicities induced by Ni, also, their fundamental mechanisms, and how to discover new ameliorative agents for prevention and treatment by reviewing agents with protective and therapeutic consequences on Ni induced toxicity.
Biodegradation of artificial petroleum based pollutants-soil mixtures via aerated bioreactor with the aid of enzymatic accelerating reagent
Authors: Al-khateeb Tala A. , Mahdi Ayat H. 
Published: February 2020

Introduction:
Pollution with oil products considered one of the most environmental problems that need to be treated significantly.Artificial polluted mixtures of pollutants and soil had been bio-treated via aerated bioreactor.

Methods:
Mixtures of used lubricating oil, crude oil and petroleum sludge had been mixed individually with soil in pre-determined ratio and treated via the bioreactor. The living microorganisms existed in soil were reinforced with enzymatic accelerating reagent to examine their activity in relatively cold ambient temperature.

Results and Conclusion:
Percentage of removal for the total organic hydrocarbons was recorded to be 74.4 %, 77.7 % and 68.2 % at the end of the fifth week of treatment of the three studied mixtures, respectively. This gives a significant indication of the ability of the used reagent combined with existing microorganisms to dissolute heavy hydrocarbon substances contaminates the soil in extreme ambient conditions.
A Concise Review on Latest Methods of Image Fusion
Authors: Joshi Kapil , Diwakar Manoj , Joshi N.K. , Lamba Sumita 
Published: February 2020

Background:
With today’s emerging world of technology, fusion is the key factor in every
field, especially in the field of medical and remote sensing. By fusing two or more images, we get
necessary useful data in a particular fused image. So it is the best technique to remove noise data
from those images.

Methods:
Noise or Blurring are those unwanted data that affects the quality of an image in terms of
clarity. There are numerous methods for image fusion that can be used to eliminate noise or blurring
that gives best results in the form of the fused image.

Conclusion:
In this paper, diverse techniques have been reviewed, studied and compared to discover
the limitations of multiple image fusion techniques.
PENGARUH KINERJA LINGKUNGAN, BIAYA LINGKUNGAN, DAN UKURAN PERUSAHAAN TERHADAP KINERJA KEUANGAN DENGAN CORPORATE SOCIAL RESPONSIBILITY SEBAGAI VARIABEL INTERVENING
Authors: Meiyana Aida , Aisyah Mimin Nur 
Published: February 2020

Abstrak : Pengaruh Kinerja Lingkungan, Biaya Lingkungan, Dan Ukuran Perusahaan Terhadap Kinerja Keuangan Dengan Corporate Social Responsibility Sebagai Variabel Intervening. Penelitian ini bertujuan untuk mengetahui (1) pengaruh kinerja lingkungan terhadap kinerja keuangan, (2) pengaruh biaya lingkungan terhadap kinerja keuangan, (3) pengaruh ukuran perusahaan terhadap kinerja keuangan, (4) pengaruh Corporate Social Responsibility (CSR) terhadap kinerja keuangan, (5) CSR sebagai mediator dalam pengaruh kinerja lingkungan terhadap kinerja keuangan, (6) CSR sebagai mediator dalam pengaruh biaya lingkungan terhadap kinerja keuangan, dan (7) CSR sebagai mediator dalam pengaruh ukuran perusahaan terhadap kinerja keuangan. Penelitian ini termasuk dalam penelitian kausal komparatif. Populasi penelitian ini adalah perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia Tahun 2014-2016. Dengan menggunakan metode purposive sampling, terdapat 39 perusahaan yang memenuhi kriteria dengan total 97 data set. Teknik analisis data yang digunakan adalah analisis regresi linier sederhana, analisis jalur, dan uji Sobel. Hasil penelitian ini menunjukkan bahwa (1) kinerja lingkungan tidak berpengaruh terhadap kinerja keuangan, (2) biaya lingkungan berpengaruh negatif terhadap kinerja keuangan, (3) ukuran perusahaan berpengaruh positif terhadap kinerja keuangan, (4) CSR berpengaruh positif terhadap kinerja keuangan, (5) CSR mampu memediasi pengaruh kinerja lingkungan terhadap kinerja keuangan, (6) CSR tidak mampu memediasi hubungan biaya lingkungan terhadap kinerja keuangan, dan (7) CSR mampu memediasi pengaruh ukuran perusahaan terhadap kinerja keuangan Kata kunci: kinerja keuangan, kinerja lingkungan, biaya lingkungan, ukuran perusahaan, Corporate Social Responsibility
Preferences for Sun Protection With a Self-Monitoring App: Protocol of a Discrete Choice Experiment Study
Authors: Nittas Vasileios , Mütsch Margot , Puhan Milo Alan 
Published: February 2020

Background
The incidence of sun-exposure-related skin conditions, such as melanoma, is a gradually increasing and largely preventable public health problem. Simultaneously, the availability of mobile apps that enable the self-monitoring of health behavior and outcomes is ever increasing. Inevitably, recent years have seen an emerging volume of electronic patient-generated health data (PGHD), as well as their targeted application across primary prevention areas, including sun protection and skin health. Despite their preventive potential, the actual impact of these apps relies on the engagement of health care consumers, who are primarily responsible for recording, sharing, and using their PGHD. Exploring preferences is a key step toward facilitating consumer engagement and ultimately realizing their potential.

Objective
This paper describes an ongoing research project that aims to elicit the preferences of health care consumers for sun protection via app-based self-monitoring.

Methods
A discrete choice experiment (DCE) will be conducted to explore how healthy consumers choose between two alternative preventive self-monitoring apps. DCE development and attribute selection were built on extensive qualitative work, consisting of the secondary use of a previously conducted scoping review, a rapid review of reviews, 13 expert interviews, and 12 health care consumer interviews, the results of which are reported in this paper. Following D-optimality criteria, a fractional factorial survey design was generated. The final DCE will be administered in the waiting room of a travel clinic, targeting a sample of 200 participants. Choice data will be analyzed with conditional logit and multinomial logit models, accounting for individual participant characteristics.

Results
An ethics approval was waived by the Ethics Committee Zurich. The study started in September 2019 and estimated data collection and completion is set for January 2020. Five two-level attributes have been selected for inclusion in the DCE, addressing (1) data generation methods, (2) privacy control, (3) data sharing with general practitioner, (4) reminder timing, and (5) costs. Data synthesis, analysis, and reporting are planned for January and February 2020. Results are expected to be submitted for publication by February 2020.

Conclusions
Our results will target technology developers, health care providers, and policy makers, potentially offering some guidance on how to design or use sun-protection-focused self-monitoring apps in ways that are responsive to consumer preferences. Preferences are ultimately linked to engagement and motivation, which are key elements for the uptake and success of digital health. Our findings will inform the design of person-centered apps, while also inspiring future preference-eliciting research in the field of emerging and complex eHealth services.

International Registered Report Identifier (IRRID)
PRR1-10.2196/16087
Study of preparatory activities on using BIM-technologies in the medical enterprise design
Authors: Karakozova Irina V. , Malykha Galina G. , Pavlov Alexander S. , Panin Andrey S. , Tesler Nadezhda D. 
Published: February 2020

Introduction. When designing buildings and installations, Building Information Modeling (BIM) is spread more and more widely. The adoption of national and international standards and classifications is of great importance for the implementation of information technology. Application of the BIM-technologies for constructing public buildings, in the first turn, medical ones, seems to be very promising. The paper discusses the problems of developing indigenous parametric blocks (families) and preparatory activities in using the BIM-technology.
Materials and methods. One of the information technology tasks is to develop equipment specifications and transfer them through the technological chain of the construction facility life cycle. The creation and application of classifiers are necessary to prepare for using the BIM-technologies.
Results. A project of an academic health science centre with an extensive equipment range is analysed. The project of a modern medical building contains a description of several hundreds of specific medical equipment types. The specifications should contain information, including denominations and quantities of the equipment units, data on overall dimensions and weights of the units, connection interfaces to the power supply, water supply, water drainage. When creating parametric blocks, the international classifiers Uniclass-2015 and OmniClass are often used. However, they do not cover the necessary equipment range and contradict the domestic practice of purchasing equipment and services for state demand.
Conclusions. The cost of preparing for the design process as creating parametric blocks can make a total of tens or hundreds of man-days that should be taken into account when planning design activities. In terms of procurement for state and municipal demand, it is necessary to make design specifications following the available range of medical equipment.
Impact of horizontal loads on the work of stud bolts in combined floor slabs
Authors: Fattakhova Alsou I. 
Published: February 2020

Introduction. Combined slabs are often applied in civil buildings. Such methods of slab calculation are described in detail in internal and international normative documents. The work of the slabs under vertical loads is studied minutely. However, additional shear forces in stud bolts from horizontal load are not considered in domestic design practice. The usage of profiled sheeting as the main reinforcement limits the application of international foreign methods is limited by. Besides that, the profiled sheeting types used abroad differ from domestic ones.
Materials and methods. The paper studies the horizontal load impact on the flexible anchors in combined slabs using profiled sheeting. The article considered an example of an existing building structure modelled using a LIRA-SAPR software system.
Results. The results of numerical experiments were described in terms of wind load and temperature effect on the structure. The values of stud bolt forces from the applied loads were obtained for various working conditions. Further, these forces were compared with the ones from the vertical loads and bearing capacity of a single stud bolt. The bearing capacity determining issue was separately considered according to domestic and foreign design standards as well as stud manufacturers’ regulatory documents. As a result, different bearing capacity values were obtained. Possible reasons for the large discrepancy of the values are given based on calculation formulae taken from documents for determining a load that a single bolt is capable of bearing.
Conclusions. A necessity of further studying the issue of providing shear rigidity of stud bolts under horizontal loads was revealed. The distribution of forces in the flexible anchors is affected by the arrangement of floor beams and ties.
Statistical and spatial variability of climate data in the Mareb-Gash river basin in Eritrea
Authors: Ghebrehiwot Anghesom A. , Kozlov Dmitriy V. 
Published: February 2020

Introduction. Global reanalysis products are extensively used for hydrologic applications in sparse data regions. The establishment of inputs for hydrologic modelling from such global reanalysis requires prior checking and analyses.
Materials and methods. The present study attempts to utilize Climate Forecast System Reanalysis (CFSR) datasets for the Mereb-Gash river basin in Eritrea, to prepare the input data for forthcoming hydrological modelling studies. The activities include statistical analyses, computation of PET, and drought indices using different methods so as to understand basin characteristics through the use of geospatial and geostatistical tools.
Results. The results of statistical analyses indicated that there was predominantly a significant monotonic trend in the majority of the data. Precipitation (P) and relative humidity tend to decrease, whereas temperature (T) and potential evapotranspiration (PET) tend to increase. Among the PET estimation methods, the Thornthwaite method gave inconsistent results as compared to Hargreaves and Penman-Monteith methods, the former being highly dependent on the elevation of the station. In most cases, it was found that Penman-Monteith produced the highest PET values.
Conclusions. Besides, Standardized Precipitation and Evapotranspiration Index (SPEI) analyses in the basin indicate persistent dry conditions over the period 2000–2013 and predominantly humid conditions over the period 1979–2000. The study concluded that the presence of a significant trend in most of the climatic variables and persistent drought conditions in recent years were found to be congruent with global and regional climatic studies that are highly likely linked to human and climate influence on the environment.
Discursos, textos y reflexiones para una formación bibliotecaria crítica
Authors: Valdunciel M. Engracia Martín 
Published: February 2020

Resumen
El artículo analiza una intervención formativa bibliotecaria enmarcada en un seminario dirigido a estudiantes de grado en España. Desde perspectivas críticas se hace una reflexión sobre el rol de la biblioteca como institución intermediaria entre diferentes formas de conocimiento y los usuarios. Se hace un balance del desarrollo de la actividad y de algunos obstáculos detectados para llevar a cabo una formación bibliotecaria crítica.
Palabras clave: Conocimiento. Poder. Capitalismo académico. Formación bibliotecaria crítica. Tecnocracia.
Resumo
O artigo analisa uma intervenção bibliotecária formativa proferida em seminário destinado a estudantes de graduação na Espanha. A partir de perspectivas críticas, faz-se uma reflexão sobre o papel da biblioteca como instituição intermediária entre diferentes formas de conhecimento e seus usuários. Faz um balanço do desenvolvimento da atividade e de alguns obstáculos detectados para realizar uma formação bibliotecaria crítica.
Palavras-chave: Conhecimento. Poder. Capitalismo académico. Formação bibliotecaria crítica. Tecnocracia.
Atlas sintático do português europeu
Authors: Magro Catarina , Vaamonde Gael 
Published: February 2020

Resumo
Este artigo apresenta um projeto em curso que visa conceber, construir e disponibilizar em linha um atlas digital da sintaxe dos dialetos do Português Europeu (SynAPse). Este atlas combina um corpus dialetal sintaticamente anotado, um motor de busca sintática e uma aplicação de webGIS e permite mapear automaticamente e de forma dinâmica os resultados de pesquisas sintáticas definidas pelos utilizadores, evidenciando a correlação espacial entre fenómenos e facilitando a identificação no território português de áreas geográficas de convergência sintática. Neste artigo, discutem-se as vantagens de um recurso cartográfico com estas características e funcionalidades para a investigação em sintaxe dialetal. Particularmente, defende-se a sua relevância para a exploração da dimensão espacial da variação sintática e para uma análise comparada das variedades dialetais numa perspetiva de Princípios & Parâmetros. Descreve-se ainda o plano de implementação técnica do atlas, com particular enfoque na etapa do processo atualmente concluída: a edição digital em XML-TEI do corpus de discurso dialetal que alimenta a ferramenta a construir e sustenta empiricamente a investigação a desenvolver.
Palavras-chave: Sintaxe dialetal. Dialetos do português europeu. Corpora digitais. Mineração de dados sintáticos. Cartografia linguística.
Resumen
Este artículo presenta um proyecto en curso cuyo objetivo es concebir, construir y ofrecer en línea un atlas digital sobre la sintaxis de los dialectos del portugués europeo (SynAPse). Este atlas combina un corpus dialectal sintácticamente anotado, um motor de búsqueda sintáctica y una aplicación webGIS, y permite mapear automáticamente y de forma dinámica los resultados de búsquedas sintácticas definidas por los usuarios, evidenciando la correlación espacial entre fenómenos y facilitando la identificación en el territorio portugués de áreas geográficas de convergencia sintáctica. En este artículo, se exponen las ventajas de un recurso cartográfico con estas características y funcionalidades para la investigación en sintaxis dialectal. Particularmente, se defiende su relevancia para la exploración de la dimensión espacial de la variación sintáctica y para un análisis comparado de las variedades dialectales desde la perspectiva de Principios y Parámetros. Finalmente, se describe el plano de implementación técnica del atlas, con especial atención a la etapa del proceso que está actualmente concluida: la edición digital en XML-TEI del corpus de discurso dialectal que alimenta a la herramienta aquí descrita y sustenta empíricamente la investigación que con ella se pretende desarrollar
Palabras clave: Sintaxis dialectal. Dialectos del portugués europeo. Corpus digitales. Minería de datos sintácticos. Cartografía lingüística.
Financial Distress, Bankruptcy Analysis and Implications For Stock Prices of Consumer Goods Companies in Indonesia
Authors: Susilowati Etty , Simangunsong John Marlintong 
Published: February 2020

Penelitian ini bertujuan untuk menganalisis financial distress dan kebangkrutan melalui metode Altman Z-Score serta pengaruhnya terhadap harga saham pada perusahaan barang konsumsi yang terdaftar di Bursa Efek Indonesia untuk periode 2012 hingga 2017. Pengambilan sampel ditentukan dengan teknik purposive sampling sedangkan pengolahan data dilakukan melalui perangkat lunak Eviews dan Microsoft Excel. Hasil penelitian menunjukkan bahwa kebangkrutan hanya terjadi di Indofarma Tbk (INAF) pada tahun 2017. Secara bersamaan, Z-score memiliki pengaruh yang signifikan terhadap harga saham dan hasil regresi data panel mengkonfirmasi bahwa Pendapatan Sebelum Bunga dan Pajak (EBIT) terhadap Total Aset memiliki pengaruh signifikan dengan kontribusi 38,25% terhadap harga saham.
Keywords : Financial Distress,Â Harga Saham, Altman Z-Score
Determination of Stress Concentration Factor (Kt) for a Crankshaft Under Bending Loading: An Artificial Neural Networks Approach
Authors: TOKTAŞ İhsan , ÖZKAN M. Tolga , ERDEMİR Fulya , YUKSEL Nurullah 
Published: February 2020

Crankshafts are used in especially engines. Crankshafts are usually effected bending and torsional stress. These loading situations are important for design of engine and its parts. Crankshaft design requires design experience and engineering calculations. When the engineering calculation is performed, stress concentration factor is put into effect. These factors are usually obtained from Stress concentration factor Charts. Reading the real stress concentration factor from charts can be resulted in getting from false values. This study is an update work of old studies. Using the new computer techniques stress concentration factor values were converted into numerical values. Stress concentration factor values were collected in a database. Artificial Neural Network (ANN) Model was improved using the database. ANN model is gave to us time economy and high accuracy of obtaining the stress concentration values.