bluuebunny/crossref_metadata_2025_split huggingface dataset:
Water, sanitation and hygiene (WASH) in sub-Saharan Africa and associations with undernutrition, and governance in children under five years of age: a systematic review
Authors: Momberg D. J. , Ngandu B. C. , Voth-Gaeddert L. E. , Cardoso Ribeiro K. , May J. , Norris S. A. , Said-Mohamed R. 
Published: January 2020

AbstractAssociations between different forms of malnutrition and environmental conditions, including water, sanitation and hygiene (WASH), may contribute towards persistently poor child health, growth and cognitive development. Experiencing poor nutrition in utero or during early childhood is furthermore associated with chronic diseases later in life. The primary responsibility for provision of water and sanitation, as a basic service and human right, lies with the State; however, a number of stakeholders are involved. The situation is most critical in sub-Saharan Africa (SSA), where, in 2015, 311 million people lacked a safe water source, and >70% of SSA populations were living without adequate sanitation. The aim of this paper was to conduct a systematic review to investigate the state of literature concerned with WASH and its association with nutritional status, and governance in children from birth to 5 years of age in SSA. Articles were sourced from PubMed Central, Science Direct and ProQuest Social Science databases published between 1990 and 2017. The PRISMA Statement was utilised and this systematic review is registered with PROSPERO (CRD42017071700). The search terms returned 15,351 articles for screening, with 46 articles included. This is indicative of a limited body of knowledge; however, the number of publications on this topic has been increasing, suggesting burgeoning field of interest. Targeted research on the governance of WASH through the identification of the various role players and stakeholders at various levels, while understanding the policy environment in relation to particular health-related outcomes is imperative to address the burden of child undernutrition.
Aspect Ratio of Eddies Inferred From Argo Floats and Satellite Altimeter Data in the Ocean
Authors: Liu ZhiYing , Liao GuangHong , Hu XiaoKai , Zhou BeiFeng 
Published: January 2020

AbstractMesoscale eddies dominate the majority of oceanic kinetic energy. The size of eddies is one of the basic properties; however, little is known about it because of lack of observations. Especially, their global vertical extent has still not been well investigated. Here, a ratio relationship of height to length scale for an eddy is derived based on dynamical constraints. Global satellite altimetry data combined with Argo float observations are used to calculate the aspect ratios of mesoscale eddies in the global ocean, and then their vertical scale is inferred. Approximately 25% of the total identified eddies with lifetimes ≥16 weeks from January 2002 to December 2017 trapped at least an Argo float near the eddy center. The result shows that the size of eddies has an obvious latitudinal dependence. Eddies at middle‐low latitudes tend to be “large and shallow” with small aspect ratios, and eddies at high latitudes tend to be “small and deep– reaching” with large aspect ratios. Such results are coarsely considered as a competition between rotation and stratification. Eddy aspect ratios in middle‐high‐latitude regions show enhanced variance compared to those in low‐latitude regions. More than half of eddies have a vertical extent smaller than 400 m. The majority of eddies extend over the mixed layer depth and are instead situated in the pycnocline. Some eddies at the middle‐high latitudes penetrate through the entire pycnocline and reach deep ocean; as such, these eddies may play an important role in linking the deep‐sea circulations and the surface circulations.
Resolving Deep Critical Zone Architecture in Complex Volcanic Terrain
Authors: Moravec Bryan G. , White Alissa M. , Root Robert A. , Sanchez Andres , Olshansky Yaniv , Paras Ben K. , Carr Bradley , McIntosh Jennifer , Pelletier Jon D. , Rasmussen Craig , Holbrook W. Steven , Chorover Jon 
Published: January 2020

AbstractCritical zone (CZ) structure, including the spatial distribution of minerals, elements, and fluid‐filled pores, evolves on geologic time scales resulting from both top‐down climatic forcing and bottom‐up geologic controls. Climate and lithology may be imprinted in subsurface structure as depth‐dependent trends in geophysical, geochemical, mineralogical, and biological datasets. As the weathering profile is as much (or more) a product of past environmental conditions, development of predictive models requires understanding the relative roles of climatic forcing and the geologic template on which CZ processes evolve. Doing so in complex volcanic terrains with high initial bedrock porosity and distinct depositional and hydrothermal alteration histories is particularly challenging. To resolve CZ structure in a rhyolitic catchment in the Valles Caldera National Preserve (NM, USA), this study combined geophysics, drilling, and laboratory analyses to produce depth‐resolved porosity, geochemistry, and mineralogy datasets to >40 m in depth. Quantitative X‐ray diffraction analysis showed that local mineral transformations control complex chemical enrichment/depletion (τ) patterns. Using linear discriminant analysis, key variables enabled separation of complex‐layered geology into discrete zones. Contemporary, matrix‐dominated weathering processes and modern hydrologic fluxes occur dominantly within the top 15 m of the weathering profile. This zone is convoluted by incomplete primary mineral weathering and overprinted by post‐eruption weathering and metasomatism. Matrix weathering transitions to fracture surface weathering driven by deep percolation of slower moving, longer residence time meteoric waters at depth. By altering initial conditions and weathering trajectory, geologic legacy is a critical factor in how this subsurface landscape evolved and functions.
Mineralization versus fermentation: evidence for two distinct anaerobic bacterial degradation pathways for dichloromethane
Authors: Chen Gao , Fisch Alexander R , Gibson Caleb M , Erin Mack E , Seger Edward S , Campagna Shawn R , Löffler Frank E 
Published: January 2020

Abstract
Dichloromethane (DCM) is an anthropogenic pollutant with ozone destruction potential that is also formed naturally. Under anoxic conditions, fermentation of DCM to acetate and formate has been reported in axenic culture Dehalobacterium formicoaceticum, and to acetate, H2 and CO2 in mixed culture RM, which harbors the DCM degrader ‘Candidatus Dichloromethanomonas elyunquensis’. RM cultures produced 28.1 ± 2.3 μmol of acetate from 155.6 ± 9.3 μmol DCM, far less than the one third (i.e., about 51.9 µmol) predicted based on the assumed fermentation model, and observed in cultures of Dehalobacterium formicoaceticum. Temporal metabolite analyses using gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance (NMR) spectroscopy revealed that no 13C-labeled acetate was formed in 13C-DCM-grown RM cultures, indicating acetate was not a direct product of DCM metabolism. The data were reconciled with DCM mineralization and H2 consumption via CO2 reduction to acetate and methane by homoacetogenic and methanogenic partner populations, respectively. In contrast, Dehalobacterium formicoaceticum produced 13C-labeled acetate and formate from 13C-DCM, consistent with a fermentation pathway. Free energy change calculations predicted that organisms with the mineralization pathway are the dominant DCM consumers in environments with H2 &lt;100 ppmv. These findings have implications for carbon and electron flow in environments where DCM is introduced through natural production processes or anthropogenic activities.
Circular RNA circ_001621 promotes osteosarcoma cells proliferation and migration by sponging miR-578 and regulating VEGF expression
Authors: Ji Xianglu , Shan Liping , Shen Peng , He Ming 
Published: January 2020

AbstractStrategies targeted vascular endothelial growth factor (VEGF)-dependent osteosarcoma progression are limited although important progress has been made in illustrating the mechanisms. Here we identified circ_001621 as one of the significantly upregulated circular RNAs (circRNAs) by circRNAs microarrays. We found that patients with high circ_001621 expression had a shorter survival time. Moreover, we found several potential sponge micro RNAs (miRNA) of circ_001621 with Circular RNA Interactome database. Among the candidate sponge, we elucidated the association of circ_001621 and miR-578. In addition, we demonstrated that miR-578 targeted circ_001621 directly. Functionally, we set up the experimental system to investigate the effects of circ_001621/miR-578/VEGF interaction in vitro and in vivo. Results indicated circ_001621-promoted osteosarcoma proliferation and migration via attenuating the inhibition of cyclin-dependent kinase 4 (CDK4) and matrix metallopeptidase 9 (MMP9) by miR-578, respectively. Nude mice experiment was further performed to estimate the promotion of metastasis by circ_001621. The present study evaluated the mechanisms underlying circ_001621 enhanced osteosarcoma progression and provided novel therapeutic targets for advanced osteosarcoma.
MicroRNA-26a/b have protective roles in oral lichen planus
Authors: Du Jie , Gao Ruifang , Wang Yimei , Nguyen Tivoli , Yang Fang , Shi Yongyan , Liu Tianjing , Liao Wang , Li Ran , Zhang Fang , Ge Xuejun , Zhao Bin 
Published: January 2020

AbstractOral lichen planus (OLP) is a kind of oral epithelial disorder featured with keratinocyte apoptosis and inflammatory reaction. The pathogenesis of OLP remains an enigma. Herein, we showed that the levels of miR-26a/b were robustly down-regulated in oral mucosal biopsies, serum and saliva in OLP patients compared with healthy control. Moreover, we found the binding sites of vitamin D receptor (VDR) in the promoter regions of miR-26a/b genes and proved that the induction of miR-26a/b was VDR dependent. The reduction of miR-26a/b expression was also detected in the oral epithelium of vitamin D deficient or VDR knockout mice. miR-26a/b inhibitors enhanced apoptosis and Type 1T helper (Th1) cells-related cytokines production in oral keratinocytes, whereas miR-26a/b mimics were protective. Mechanistically, we analyzed miRNA target genes and confirmed that miR-26a/b blocked apoptosis by directly targeting Protein Kinase C δ (PKCδ) which promotes cellular apoptotic processes. Meanwhile, miR-26a/b suppressed Th1-related cytokines secretion through targeting cluster of the differentiation 38 (CD38). In accordant with miR-26a/b decreases, PKCδ and CD38 levels were highly elevated in OLP patients’ samples. Taken together, our present investigations suggest that vitamin D/VDR-induced miR-26a/b take protective functions in OLP via both inhibiting apoptosis and impeding inflammatory response in oral keratinocytes.
Blockchain vehicles for efficient Medical Record management
Authors: Vazirani Anuraag A. , O’Donoghue Odhran , Brindley David , Meinert Edward 
Published: January 2020

AbstractThe lack of interoperability in Britain’s medical records systems precludes the realisation of benefits generated by increased spending elsewhere in healthcare. Growing concerns regarding the security of online medical data following breaches, and regarding regulations governing data ownership, mandate strict parameters in the development of efficient methods to administrate medical records. Furthermore, consideration must be placed on the rise of connected devices, which vastly increase the amount of data that can be collected in order to improve a patient’s long-term health outcomes. Increasing numbers of healthcare systems are developing Blockchain-based systems to manage medical data. A Blockchain is a decentralised, continuously growing online ledger of records, validated by members of the network. Traditionally used to manage cryptocurrency records, distributed ledger technology can be applied to various aspects of healthcare. In this manuscript, we focus on how Electronic Medical Records in particular can be managed by Blockchain, and how the introduction of this novel technology can create a more efficient and interoperable infrastructure to manage records that leads to improved healthcare outcomes, while maintaining patient data ownership and without compromising privacy or security of sensitive data.
Brevetabilité d’un anticorps
Authors: Collin Matthieu , Davison Sophie 
Published: January 2020

Les anticorps monoclonaux représentent aujourd’hui la classe médicamenteuse la plus importante en termes de ventes mondiales. L’obtention d’une protection par brevet de ces molécules est donc cruciale. Une dynamique active de dépôts de demandes de brevets pour protéger les inventions que ces molécules représentent existe donc autant dans l’industrie que dans le monde de la recherche académique. Cependant, les demandeurs doivent faire face à des difficultés récurrentes pour obtenir des brevets de portée importante et faire valoir leurs droits devant les tribunaux. Les trois critères les plus débattus autour des revendications d’anticorps sont : la suffisance/clarté de l’invention, la nouveauté et l’activité inventive. L’objectif de cet article est donc de faire un état des lieux de la pratique en la matière.
Anesthetic Challenges in Minimally Invasive Cardiac Surgery
Authors: Balasubramanyam Uma , Kapoor Poonam Malhotra 
Published: January 2020

AbstractThe transition of cardiac surgery away from the traditional sternotomy approach toward more minimally invasive strategies continues to evolve over time. The first minimally invasive cardiac surgery was performed in 2005 in New York by a team led by Dr. Joseph T. McGinn. Anesthesiologists play in a key role in facilitating optimal outcomes in such procedures. Perioperative management of these patients poses specific challenges to the anesthesia team. The anesthesiologist must be skilled in numerous subspecialty skillsets including regional anesthesia and analgesia techniques, and elements of thoracic anesthesia practice, in particular one-lung ventilation (OLV), cardiac anesthesia, and transesophageal echocardiography.
Term Labor Outcomes after Cerclage Placement in a Multi-institutional Cohort
Authors: Bauer Alison M. , Lappen Justin R. , Hackney David N. 
Published: January 2020

Abstract
Objective The placement of a cervical cerclage in early pregnancy could influence subsequent labor outcomes at term. Prior studies have yielded conflicting results regarding the potential association with adverse labor outcomes such as cesarean delivery (CD), cervical laceration, and prolonged labor. Our objective was to evaluate rate of CD and adverse maternal outcomes in women who labored at term with and without a cerclage within the Consortium on Safe Labor (CSL) cohort. We hypothesize that women with a cerclage in the incident pregnancy will have an increased frequency of CD and other adverse term labor outcomes.
Study Design A retrospective cohort study was performed using data from the CSL. Women with live nonanomalous singleton gestations≥ 37 weeks with induced or spontaneous labor were identified. The risk of CD and other maternal and neonatal outcomes were compared between women with and without cerclage placement during pregnancy. Univariable and multivariable analyses were performed with adjustment for confounding factors. Planned subgroup analysis by history of CD was performed.
Results A total of 374 of the 147,463 patients who met study inclusion criteria in the CSL (0.25%) had a cerclage. In univariable analysis, cerclage placement was associated with a significant increase in the frequency of CD (17.1 vs. 12.8%, p = 0.016, odds ratio: 1.4, 95% CI: 1.07–1.84), cervical lacerations, infectious morbidity, and blood loss. The association with CD persisted in multivariable regression. Cerclage placement was not associated with an increased risk of neonatal morbidity.
Conclusion Cerclage placement in pregnancy is associated with an increased risk of CD, cervical laceration, and infectious morbidity among women delivering at term. These findings suggest that cerclage placement may impact labor progression and outcomes. However, the magnitude of the association may not alter clinical decisions regarding cerclage placement in appropriate candidates.
Electron number density measurements in nanosecond repetitively pulsed discharges in water vapor at atmospheric pressure
Authors: Sainct Florent P , Urabe Keiichiro , Pannier Erwan , Lacoste Deanna A , Laux Christophe O 
Published: January 2020

Abstract
This article reports on experiments in a nonequilibrium plasma produced by nanosecond repetitively pulsed (NRP) spark discharges in water vapor at 450 K and atmospheric pressure. The objective is to determine the electron number density in the post-discharge, with spatial and temporal resolution, to gain a better understanding of the discharge development and chemical kinetics. Electron number densities were measured in water vapor from the broadenings and shifts of the H
α
and H
β
lines of the hydrogen Balmer series and of the atomic oxygen triplet at 777 nm. For an average reduced electric field of about 150 Td, high electron densities up to 3 × 1018 cm−3 are measured at the cathode, up to 5 × 1017 cm−3 at the anode, and up to 4 × 1016 cm−3 in the interelectrode gap. The high density near the electrodes is attributed to ionization enhancement and secondary electron emission due to the high electric field in the plasma sheath. In the middle of the inter-electrode gap, we show that the electron density mainly decays by electron attachment reactions. The dissociation fraction of water vapor is estimated to be around 2% in the middle of the gap.
Enhancement of ultrafast photoluminescence from deformed graphene studied by optical localization microscopy
Authors: Chen En-Xiang , Cheng Hao-Yu , Chen Zheng-Gang , Chen Wei-Liang , Kataria Monika , Chang Yu-Ming , Chen Yang-Fang , Su Wei-Bin , Lin Kung-Hsuan 
Published: January 2020

Abstract
By using localization techniques, we demonstrated that the morphology of a 2D material in three dimensions can be optically obtained with nanometer precision in z-axis. This technique provides a convenient method to study the correlation between the optical properties and the morphology of 2D materials for the same area. We utilized optical localization microscopy to directly study the correlation between the ultrafast photoluminescence and the morphology of graphene. We observed enhancement of the ultrafast photoluminescence from the deformed graphene. In comparison to the planar graphene, the enhancement factor of ultrafast photoluminescence could be up to several times at the highly curved region. We found that the intensity of photoluminescence from the uniaxially rippled graphene depends on the polarization of excitation light. Furthermore, Raman spectroscopy was used to measure the strain distribution. Pump–probe measurements were conducted to reveal the carrier dynamics. From the experimental results, two mechanisms were confirmed to mainly account for the enhancement of ultrafast photoluminescence from the deformed graphene. One is the deformation-induced strain increases the absorption of graphene. The other is the prolonged carrier relaxation time in the curved graphene.
Effect of different coupling agents in the doping of graphite oxide with 3–3′ diaminobenzidine: textural, structural and electrical properties
Authors: Cervantes-Cuevas H , Jiménez-Hernández M , Chavez-Esquivel G , Acosta Dwight , Tavizon-Pozos J A , Santolalla-Vargas C E , Talavera-López A 
Published: January 2020

Abstract
The doping reactions of graphite oxide (GO) with 3-3′-diaminobenzidine (DAB) were studied using N, N′-dicyclohexylcarbodiimide (DCC), cyanuric chloride (CC) and hexafluorophosphate (HATU) as coupling agents. The bifunctionality of the coupling agents aid to interact GO functional groups with amino groups of DAB without being part of the final product. The doped materials (d-GO) and GO were characterized by thermogravimetric analysis, x-ray diffraction, FTIR/Raman spectroscopy, x-ray photoelectron, high-resolution electron microscopy and cyclic voltammetry. The GO-HATU material was more thermally stable than other graphitic material, with at 10% weight loss at 300 °C, this thermal stability is related to a more difficult intramolecular physisorbed water removal process than the other d-GO materials. GO-CC and GO-HATU materials presented 8.2 and 8.0 Å of interlayer spacing, which was associated with a good oxidation-doping process. Besides, these two materials showed modifications in the vibrations by FTIR technique, corresponding to epoxy and hydroxyl groups of the GO being more susceptible to react with the amino groups. Moreover, I

D
/I

G
ratio calculated by Raman Spectroscopy presents the following trend 0.70, 0.94, 0.97 and 1.04 for GO, GO-CC, GO-DCC and GO-HATU, respectively, this increase is related with a major disorder during the doping process. XPS analysis shows C–N and N=C bands for high resolution of C 1s and N 1s, respectively, for d-GO materials. This possibly suggests the formation of benzimidazoles during the oxidation-doping process, this generates a similar -non-lattice and -lattice oxygen amount for O 1s related to crosslinking between the functional groups of GO and DAB which improve the electronic mobility between the surface and the bulk of the final graphitic material. Finally, the obtained d-GO materials were investigated as a working electrode for electrochemical capacitors and all of them showed typical capacitive behaviour.
Fabrication of Ananas comosus leaf extract modified titanium dioxide nano bio adsorbent for the sequestration of basic dye from aqueous phase: equilibrium and kinetic studies
Authors: Fakhar Nida , Siddiqi Weqar Ahmad , Khan Tabrez Alam , Siddiqui Mohammad Fuzail 
Published: January 2020

Abstract
A novel, titanium dioxide nano bio-adsorbent (TiO2L) based on Ananas comosus leaf extract was developed by sol-gel route and was subsequently used to decolorize toxic non-biodegradable basic dye Victoria blue (VB) from the aqueous solution. Several techniques were used to characterize the synthesized bio-adsorbent like XRD, FTIR, SEM-EDX and TEM to observe physio-chemical changes and adsorption interactions. The impact of process parameters on the adsorption behavior of TiO2L towards VB were comprehensively studied and the optimized conditions were initial dye concentration (50 mg L−1), dose (1.8 g L−1), contact time (40 min), and pH (6) of the solution. Different isotherm and kinetic models were used to analyze the equilibrium data among which Langmuir model appropriately fitted the equilibrium data based on high R2 (0.994) and pseudo second order described the reaction kinetics of VB adsorption onto the adsorbent. The maximum adsorption capacity was found to be 83 mg g−1. Dye loaded adsorbent was regenerated and used for 3 cycles without subsequent loss in its efficiency. Thus, economic feasibility, environmentally friendly, better sorption capacity and regeneration potential, validates TiO2L as a potential adsorbent for VB from wastewater.