bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mesenchymal Stem Cells Promote Caspase Expression in Molt-4 Leukemia Cells Via GSK-3α/Β and ERK1/2 Signaling Pathways as a Therapeutic Strategy
Authors: Fathi Ezzatollah , Vietor Ilja 
Published: October 2020

Background:
Mesenchymal stem cells (MSCs) are considered an interesting tool in cell
therapy due to their unique features such as self-renewal, multi-potency, and pluripotency. The multifunctional
properties of these cells are being investigated in many studies. The current research examined
the influence of MSCs on the Molt-4 cell line as acute lymphoblastic leukemia (ALL)
cells.

Methods:
MSCs were cultured, characterized, and co-cultured with Molt-4 cells in a trans-well system.
Then, cultured Molt-4 alone and Molt-4 co-cultured with MSCs (10:1) were collected on day
7 and subjected to western blotting for protein expression assessment. Telomerase activity as well
as cell senescence, were investigated by PCR-ELISA TRAP assay and β-galactosidase activity measurement,
respectively.

Results:
It was found that MSCs resulted in a significant increase in the pro-caspase-8 and
cleaved-caspase 8 and 9 expression levels. Furthermore, protein expression levels of GSK-3α/β
and ERK1/2 were significantly decreased. The results also showed that MSCs caused significant decreases
and increases in telomerase and β-galactosidase enzyme activity of Molt-4 cells, respectively.

Conclusions:
It was concluded that MSCs co-cultured with Molt-4 cells could be involved in the
promotion of Molt-4 cell apoptosis and cell senescence via caspase-8, 9 cascade and GSK-3α/β
and ERK1/2 signaling pathways.
A Case of Quinacrine-induced Psychosis: Case Report
Authors: Pedapudi Anangamanjari , Stewart Jonathan , Patel Ankita 
Published: October 2020

Background:
Quinacrine is an older antimalarial drug that remains in use for a variety
of illnesses including treatment-resistant giardiasis.

Case Presentation:
We report a patient with no prior psychiatric history who developed mild, prodromal
psychiatric symptoms when treated with quinacrine for treatment-resistant giardiasis. Symptoms
resolved when the drug was stopped, recurred with greater severity (requiring involuntary
psychiatric hospitalization) when restarted and promptly resolved again when the drug was finally
stopped.

Conclusion:
Although quinacrine remains in use today, providers may be unaware of its potential
for serious neuropsychiatric toxicity.
Effect of Students' Emotions on their Positive Psychology: A Study of Higher Education Institutions
Authors: Grover Rajat , Aggarwal Arun , Mittal Amit 
Published: October 2020

Background:
In the higher education sector, anticipating and fostering positive emotions manifest the view of positive psychology is considered as an essential practice.

Aims:
The present study aims to identify and statistically validate the different types of students’ emotional indicators.

Methods:
A survey was carried out in three cities, namely Mumbai, Pune, and Chandigarh of India. A total of 566 valid survey responses were analyzed using exploratory factor analysis and confirmatory factor analysis. The results of the confirmatory factor analysis demonstrated six sets of emotions measurement indicators, namely anger, disgust, happiness, positive emotions, sadness, and fear for measuring students’ emotions.

Results:
Further, the results of path analysis showed that happiness, positive emotions, sadness, disgust, and fear had positive effect on positive psychology.

Conclusion:
Overall, this study highlights the imperativeness of students’ emotional measurement, and the study results provide a deep understanding of both positive and negative emotions measurement, which may further support the overall development of the students, especially in higher education institutions.
Young People’s Attitude Toward Positive Psychology Interventions: Thematic Analysis
Authors: Michel Toni , Tachtler Franziska , Slovak Petr , Fitzpatrick Geraldine 
Published: October 2020

Background
Digital instantiations of positive psychology intervention (PPI) principles have been proposed to combat the current global youth mental health crisis; however, young people are largely not engaging with available resources.

Objective
The aim of this study is to explore young people’s attitudes toward various PPI principles to find ways of making digital instantiations of them more engaging.

Methods
We conducted an explorative workshop with 30 young people (aged 16-21 years). They rated and reviewed 29 common PPIs. Ratings and recorded discussions were analyzed using thematic analysis.

Results
Some interventions were conflicting with young people’s values or perceived as too difficult. Participants responded positively to interventions that fit them personally and allowed them to use their strengths.

Conclusions
Values, context, strengths, and other personal factors are entangled with young people’s attitudes toward digital instantiations of PPI principles.
Effectiveness of Chair Aerobics and Swiss Ball in Primary Dysmenorrhoea
Authors: Mintu Merin Koshy  , Dr. Smita Chandrakant Patil  , Dr. Chandrakant Babaso Patil  , Dr. Khushboo Trishant Chotai  
Published: October 2020

Dysmenorrhoea is the pain that occurs during menstruation. It is one of the common gynaecological disorders that affects women’s quality of life and day to day activities. Primary dysmenorrhoea (PD) is characterised by cramping lower abdomen pain that may radiate to the lower back and upper thigh. Associated complaints include stress, depression, headache and diarrhoea. The overall prevalence of primary dysmenorrhoea is about 60% - 90%. There are many conservative treatments for primary dysmenorrhoea conditions but more effective one is not yet known. Hence it is necessary to find the effectiveness of chair aerobics and swiss ball in primary dysmenorrhoea. The study was conducted with 50 subjects in and around Krishna Institute of Medical Sciences campus who have primary dysmenorrhoea symptoms. The subjects are divide into two groups, Group A and B. Group A were given chair aerobics exercises and Group B were given swiss ball exercises. The result of this study was analysed by the basis of pre-test and post-test assessment of VAS and VMSS. Arithmetic mean & standard deviation was calculated for each outcome measure. MS Excel was used for drawing various graphs with given frequencies. According to the pre-test and post-test analysis the result showed that swiss ball exercises are statistically significant in reducing VAS and VMSS score than chair aerobics exercises in primary dysmenorrhoea. On the basis of the results it is concluded that the swiss ball exercises are more effective than chair aerobics in decreasing pain and improving quality of life in primary dysmenorrhoea.
Evaluación del rendimiento diagnóstico de los criterios predictivos de la sociedad británica para el diagnóstico de coledocolitiasis en una población colombiana
Authors: Gastelbondo Morales Johanna Alexandra , Otero Regino William , Gómez Zuleta Martín Alonso 
Published: October 2020

Introducción: la coledocolitiasis (CLDL) puede ser difícil de diagnosticar. Su importancia radica en sus potenciales complicaciones y en que el tratamiento se realiza mediante colangiopancreatografía retrógrada endoscópica (CPRE), un procedimiento con riesgo de generar complicaciones. Se han propuesto guías para su diagnóstico y la más empleada es la de la ASGE (American Society for Gastrointestinal Endoscopy), cuyo rendimiento no es ideal. Recientemente, se ha publicado la guía británica. Este estudio se realizó para establecer el rendimiento de ambas guías.
Materiales y métodos: estudio prospectivo realizado entre agosto 1 de 2017 y julio 31 de 2018.
Resultados: se incluyeron 300 pacientes para el análisis. Se realizó una CPRE en 145 pacientes y se confirmó la existencia de CLDL en 124 de ellos (85,5 %). La mediana de aspartato aminotransferasa (AST) y alanina aminotransferasa (ALT) fue mayor en los que tuvieron CLDC (207 mg/dL y 290 mg/dl, respectivamente). Entre tanto, la tasa de complicaciones posteriores a la CPRE fue del 5,5 %. El análisis multivariado no encontró una asociación significativa para alguna variable predictora de CLDL. En pacientes con alta probabilidad, las guías británicas tuvieron una sensibilidad del 65 % y una especificidad del 33 %, mientras que las guías ASGE mostraron una sensibilidad del 74 % y una especificidad del 28 %. En probabilidad intermedia fueron menos eficientes.
Conclusiones: los criterios de la ASGE y la BSG (British Society of Gastroenterology) no tienen un buen desempeño en la población estudiada, a fin de discriminar la existencia o no de CLDL. La guía de la ASGE mostró un mejor rendimiento en general que las guías británicas.
Caracterización demográfica de la población con esófago de Barrett en dos instituciones médicas de Bogotá, Colombia.
Authors: Bernal Vaca Maria Lucia , Garcia Arévalo Harol Felipe , De Molano Belén Mendoza 
Published: October 2020

Introducción: el esófago de Barrett es un trastorno en el que ocurre un cambio del epitelio escamoso estratificado del esófago por uno columnar especializado, lo cual se da como consecuencia del reflujo gastroesofágico crónico. En Colombia no se conoce la prevalencia actual de esta patología, ni se ha caracterizado a la población que la padece. El presente estudio tiene como objetivo conocer cuáles son las características demográficas principales de la población diagnosticada con esófago de Barrett en dos instituciones médicas de Bogotá.
Material y métodos: se realizó un estudio de corte transversal multicéntrico, en el cual se evaluaron los reportes de endoscopias y de histopatología de 3000 pacientes que asistieron a estas instituciones por cualquier indicación. A partir de estos reportes se tomaron los datos requeridos. Asimismo, se realizó un análisis estadístico descriptivo de dichos datos.
Resultados: la prevalencia del esófago de Barrett en la muestra es del 0,73 %. Se observó, además, que la correlación endoscópico-patológica es baja (28,5 %). De los casos diagnosticados, el rango de edad más frecuente se ubica entre los 60 y 80 años, con una edad promedio de 65,5 años. Asimismo, existe una predominancia de esta patología en el sexo femenino (63,6 %), en personas con un índice de masa corporal (IMC) >25 kg/m² y en aquellas con antecedentes de tabaquismo, sin historial de consumo de alcohol. En la mayoría de pacientes, se realizó la endoscopia por síntomas de reflujo gastroesofágico (50 %). La longitud del segmento observado no fue reportada en una gran cantidad de endoscopias.
Conclusiones: en las instituciones analizadas, el esófago de Barrett es una patología de muy baja prevalencia y predominante en mujeres de edad avanzada con síntomas de reflujo gastroesofágico, sobrepeso y antecedente de tabaquismo.
Caducidad de la comunicación de subasta el tercero registral conforme la aplicación de los principios registrales
Authors: Descalzo Vanesa Natalia 
Published: October 2020

Este trabajo efectúa un análisis de la caducidad de la comunicación de subasta, tanto desde el derecho sustantivo como desde el punto de vista procesal. Se analiza la buena fe de los terceros embargantes y los adquirentes, desde el estudio de la institución subasta, sus momentos, y el impacto de los principios registrales en la misma (principalmente buena fe y caducidad) para así poder comprender el alcance y finalidad de la comunicación de subasta. Palabras Claves: Principios registrales  subasta  comunicación de subasta  inscripción  caducidad registral
El artículo 6 de la ley 10.432. mas alla de las prerrogativas otorgadas por la ley nacional registral
Authors: Contreras Federico A. 
Published: October 2020

Este trabajo se estructura sobre el análisis de la norma provincial Nro. 10.432, la cual en post de actualizar y modernizar el sistema procedió fijar como el plazo de los certificados notariales en un plazo único y genérico de 30 días, a tales fines se analiza el principio registral de prioridad, sus impactos, la reserva de prioridad y la determinación e impacto de los plazos de vigencia del certificado. Se contrapone la normativa provincial con la nacional y se analizan los posibles planteos de inconstitucionalidad que podrían darse. Palabras claves: Principios registrales  certificado registral  principio de inscripción
Changes in Statin Use Among U.S. Adults With Diabetes: A Population-Based Analysis of NHANES 2011–2018
Authors: Leino Abbie D. , Dorsch Michael P. , Lester Corey A. 
Published: October 2020

OBJECTIVE
To evaluate statin use in the U.S. before and after the 2015 American Diabetes Association position statement, which expanded statin therapy recommendations to include all adults 40–75 years old with diabetes.

RESEARCH DESIGN AND METHODS
The National Health and Nutrition Examination Survey (NHANES) was used to obtain a representative sample. The difference-in-differences technique determined the impact of the recommendation on the proportion of people with diabetes for whom statin therapy was newly recommended.

RESULTS
Among people with diabetes, the change in statin use in people without atherosclerotic cardiovascular disease (ASCVD) risk factors, controlling for change among people with ASCVD/risk factors, was 6.6% (P = 0.388). In the adjusted analysis, overt ASCVD, age, Black race, health insurance, a place for routine care, and total cholesterol were significantly associated with statin use (P &lt; 0.05).

CONCLUSIONS
The most recent change in statin recommendations had minimal impact on the proportion of patients receiving a statin.
Intratrial Exposure to Vitamin D and New-Onset Diabetes Among Adults With Prediabetes: A Secondary Analysis From the Vitamin D and Type 2 Diabetes (D2d) Study
Authors: Dawson-Hughes Bess , Staten Myrlene A. , Knowler William C. , Nelson Jason , Vickery Ellen M. , LeBlanc Erin S. , Neff Lisa M. , Park Jean , Pittas Anastassios G. 
Published: October 2020

OBJECTIVE
Postrandomization biases may influence the estimate of efficacy of supplemental vitamin D in diabetes prevention trials. In the Vitamin D and Type 2 Diabetes (D2d) study, repeated measures of serum 25-hydroxyvitamin D [25(OH)D] level provided an opportunity to test whether intratrial vitamin D exposure affected diabetes risk and whether the effect was modified by trial assignment (vitamin D vs. placebo).

RESEARCH DESIGN AND METHODS
The D2d study compared the effect of daily supplementation with 100 μg (4,000 units) of vitamin D3 versus placebo on new-onset diabetes in adults with prediabetes. Intratrial vitamin D exposure was calculated as the cumulative rolling mean of annual serum 25(OH)D measurements. Hazard ratios for diabetes among participants who had intratrial 25(OH)D levels of &lt;50, 75–99, 100–124, and ≥125 nmol/L were compared with those with levels of 50–74 nmol/L (the range considered adequate by the National Academy of Medicine) in the entire cohort and by trial assignment.

RESULTS
There was an interaction of trial assignment with intratrial 25(OH)D level in predicting diabetes risk (interaction P = 0.018). The hazard ratio for diabetes for an increase of 25 nmol/L in intratrial 25(OH)D level was 0.75 (95% CI 0.68–0.82) among those assigned to vitamin D and 0.90 (0.80–1.02) among those assigned to placebo. The hazard ratios for diabetes among participants treated with vitamin D who maintained intratrial 25(OH)D levels of 100–124 and ≥125 nmol/L were 0.48 (0.29–0.80) and 0.29 (0.17–0.50), respectively, compared with those who maintained a level of 50–74 nmol/L.

CONCLUSIONS
Daily vitamin D supplementation to maintain a serum 25(OH)D level ≥100 nmol/L is a promising approach to reducing the risk of diabetes in adults with prediabetes.
Study protocol: DigiHand – the emergence of handwriting skills in digital classrooms
Authors: Gamlem Siv M. , Mork Rogne Wenke , Rønneberg Vibeke , Uppstad Per Henning 
Published: October 2020

This protocol article presents the project “DigiHand: The emergence of handwriting skills in digital classrooms.”1 The project is a longitudinal natural experiment investigating how the use of different writing tools influences students’ handwriting and letter knowledge, word reading, spelling, written narrative composition and teacher–student interactions in Grades 1 and 2 (students aged 6 years in Grade 1). Participants are 33 schools (n = 585 students) representing three occurring conditions for learning writing skills in early years. Students in these conditions either (1) learn to write on a tablet while postponing handwriting, (2) learn both to handwrite and write on a tablet or (3) learn to handwrite. Effect analyses are conducted on four main domains of measures: (i) students’ letter knowledge, spelling competence and word reading competence; (ii) students’ handwriting fluency; (iii) students’ ability to write narrative compositions; (iv) quality of teacher–student interactions. This protocol describes the background, design and pre- and outcome measures for the research project.
COVID-19 in Ghana: Knowledge, perception and practice among health trainees
Authors: Adu David Kwabena , Gyan Bernard , Dzokoto Maxwell Kwame , Addai Richard , Woli Moses Kofi , Boamah Bismark , Puplampu Paapa , Ofori Emmanuel , Baffoe Augustine , Bonsu Albert , Opoku-Adusei Kwabena 
Published: October 2020

Objective: This study assessed the knowledge, perceptions and practices among health trainees in Ghana regarding COVID-19. Understanding the knowledge, perception and practices among health trainees can provide important information for policy formulations and proper planning.Method: The survey was conducted through a Google form link shared on students’ social media networks mainly through Facebook, and WhatsApp platforms. Responses received were imported to SPSS version 24 for cleaning and analysis. Output measures were demonstrated in simple frequency and percentages, using tables and charts. Fisher’s exact test was used to assess the effect of potential covariate on practice of preventive measures with their corresponding p-values. Results: Twenty-five percent (25%) of respondents had good knowledge, 69% had moderate knowledge and 6% had poor knowledge on COVID-19. Regarding perception of health students on COVID-19, 8.47% indicated that drinking alcohol could protect them from the virus. More than 90% of participants’ practice the general preventive measures. Gender and level of program of study was found to be significantly associated with practice of preventive measure. Male students (54.64%) were engaged in good preventive practices compared to female students (43.75%).Conclusion: Majority of the health trainees had basic information and proactive practice towards COVID-19. Most trainees had good perception on the disease, however, a few still believe that drinking alcohol will prevent them from being infected with the disease. Gender and level of trainees are significant predictors of proactive practices towards COVID-19.
IMPLEMENTASI PEMBELAJARAN DARING BERBASIS EDMODO PADA MATA KULIAH EVALUASI PROGRAM KEPELATIHAN DI MASA PANDEMI COVID-19
Authors: Ningsih Sulia 
Published: October 2020

Abstrak: Sistem pendidikan di Indonesia sejak awal tahun 2020 telah mengalami perubahan yang cukup signifikan akibat pandemi Covid-19. Pembelajaran daring menjadi solusi untuk mengurangi kemungkinan menyebarnya virus ini dengan menggunakan media online. Edmodo adalah salah satu media online yang dapat digunakan pada pembelajaran, termasuk pada mata kuliah Evaluasi Program Kepelatihan. Penelitian ini bertujuan untuk menganalisis implementasi pembelajaran daring berbasis edmodo yang digunakan untuk pembelajaran daring pada mata kuliah Evaluasi Program Kepelatihan. Metode penelitian yang digunakan adalah kualitatif deskriptif. Hasil penelitian menunjukkan bahwa (1) Pemilihan edmodo sebagai media pembelajaran daring pada mata kuliah Evaluasi Program Kepelatihan didasarkan pada analisis kebutuhan mahasiswa dengan alasan kemudahan dan penguasaan aplikasi. (2) Perencanaan pembelajaran daring berbasis edmodo tergambar di rencana pembelajaran semester (RPS); (3) Implementasi pembelajaran daring berbasis edmodo dilaksanakan berdasarkan RPS dengan baik dan lancar; (4) Edmodo membantu pelaksanaan evaluasi pembelajaran untuk mengukur hasil belajar mahasiswa.Kata Kunci: implementasi, pembelajaran daring, edmodo, covid-19 Abstract: The education system in Indonesia since the beginning of 2020 has undergone significant changes due to the Covid-19 pandemic. Online learning is a solution to reduce the possibility of spreading this virus by using online media. Edmodo is an online media that can be used in learning, including in the Coaching Program Evaluation course. This study aims to analyze the implementation of edmodo-based online learning which is used for online learning in the Coaching Program Evaluation course. The research method used is descriptive qualitative. The results showed that (1) The selection of Edmodo as an online learning medium in the Coaching Program Evaluation course was based on an analysis of student needs on the grounds of ease and mastery of applications. (2) Edmodo-based online learning planning is reflected in the semester learning plan (RPS); (3) The implementation of edmodo-based online learning is carried out well and smoothly based on RPS; (4) Edmodo helps implement learning evaluations to measure student learning outcomes.Keywords: implementation, online learning, edmodo, covid-19
Occupational Well-Being of School Staff in Full Day and Half Day School Teachers
Authors: Rahma Ulifa , Anggreni Yulia Dwi , Faizah Faizah , Dara Yuliezar Perwira 
Published: October 2020

This research is a phenomenology study in qualitative about the portrayal of occupational well-being of school staff at Full Day School and Half Day School in Senior High School teachers, which is based on Saaranen's theory (2012). The interviews were used as data. Purposive sampling, eight primary teachers were selected, including four teachers from Universitas Negeri Malang Laboratory Senior High School as the full-day school and four teachers from Panjura Senior High School as a half-day school. Milles and Huberman were used as the data analysis following by triangulation techniques. The results showed that full-day and half-day schools needed to maintain the positive aspects that were fulfilled and improve improvement. A full-day school, the elements that have fulfilled are the workers' health and resources, professional competence, working conditions, and working communities. Meanwhile, the factors that have fulfilled are the aspects of the working community, the workers’ health and resources, and professional competence at half day school. In contrast, the element that needs to improve in this school is working conditions. Penelitian ini merupakan penelitian kualitatif jenis fenomenologi mengenai gambaran occupational well-being of school staff pada guru Sekolah Menengah Atas Full Day School dan Half Day School, yang berdasar pada teori Saaranen (2012). Data yang digunakan oleh peneliti melalui wawancara, dengan menggunakan purposive sampling sebanyak delapan guru primer diantaranya empat guru di SMA Laboratorium Universitas Negeri Malang sebagai sekolah full day dan empat guru di SMA Panjura sebagai sekolah half day. Analisis data yang digunakan yaitu analisis data Milles dan Huberman serta menggunakan teknik triangulasi sumber. Hasil penelitian menunjukkan bahwa sekolah fullday dan halfday perlu mempertahankan aspek positif yang terpenuhi dan meningkatkan hal yang masih perlu diperbaiki. Pada sekolah full day, aspek yang telah terpenuhi yaitu aspek workers health and resources, professional competence, working conditions dan working community. Pada sekolah half day, yang telah terpenuhi yaitu aspek working community, workers health and resources, dan professional competence, sedangkan untuk aspek yang perlu ditingkatkan pada sekolah ini yaitu aspek working conditions.