bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early management of sepsis in medical patients in rural Thailand: a single-center prospective observational study
Authors: Rudd Kristina E. , Hantrakun Viriya , Somayaji Ranjani , Booraphun Suchart , Boonsri Chaiyaporn , Fitzpatrick Annette L. , Day Nicholas P. J. , Teparrukkul Prapit , Limmathurotsakul Direk , West T. Eoin 
Published: December 2019

Abstract
Background
The burden of sepsis is highest in low- and middle-income countries, though the management of sepsis in these settings is poorly characterized. Therefore, the objective of this study was to assess the early management of sepsis in Thailand.

Methods
Pre-planned analysis of the Ubon-sepsis study, a single-center prospective cohort study of Thai adults admitted to the general medical wards and medical intensive care units (ICUs) of a regional referral hospital with community-acquired sepsis.

Results
Between March 2013 and January 2017, 3,716 patients with sepsis were enrolled. The median age was 59 years (IQR 44-72, range 18-101), 58% were male, and 88% were transferred from other hospitals. Eighty-six percent of patients (N = 3,206) were evaluated in the Emergency Department (ED), where median length of stay was less than 1 hour. Within the first day of admission, most patients (83%, N = 3,089) were admitted to the general medical wards, while 17% were admitted to the ICUs. Patients admitted to the ICUs had similar age, gender, and comorbidities, but had more organ dysfunction and were more likely to receive measured sepsis management interventions. Overall, 84% (N = 3,136) had blood cultures ordered and 89% (N = 3,308) received antibiotics within the first day of hospital admission. Among the 3,089 patients admitted to the general medical wards, 38% (N = 1,165) received an adrenergic agent, and 21% (N = 650) received invasive mechanical ventilation. Overall mortality at 28 days was 21% (765/3,716), and 28-day mortality in patients admitted to the ICUs was higher than that in patients admitted to the general medical wards within the first day (42% [263/627] vs. 16% [502/3,089], p < 0.001).

Conclusions
Sepsis in a regional referral hospital in rural Thailand, where some critical care resources are limited, is commonly managed on general medical wards despite high rates of respiratory failure and shock. Enhancing sepsis care in the ED and general wards, as well as improving access to ICUs, may be beneficial in reducing mortality.

Trial registration
The Ubon-sepsis study was registered on clinicaltrials.gov (NCT02217592).
Test-retest reliability, internal consistency, construct validity and factor structure of a falls risk perception questionnaire in older adults with type 2 diabetes mellitus: a prospective cohort study
Authors: Gravesande Janelle , Richardson Julie , Griffith Lauren , Scott Fran 
Published: December 2019

Abstract
Background
Older adults with type 2 diabetes (DM2) are at increased risk of falling due to complications including: diabetic peripheral neuropathy, diabetic retinopathy, autonomic neuropathy and diabetic foot ulcers. The purpose of this study was to determine the test-retest reliability, internal consistency, construct validity and to perform factor analysis of a new falls Risk Perception Questionnaire (RPQ) in older community-dwelling adults with DM2.

Methods
A prospective cohort of 30 community-dwelling older adults, ≥ 55 years, with DM2 was assembled. At baseline, perceived risk of falling, fear of falling and physical activity were measured. At time 2 (T2), at least 2 days later, perceived risk of falling was assessed again to determine the test-retest reliability of the RPQ. At time 3 (T3), approximately six weeks later, and time 4 (T4), at least 2 days after T3, perceived risk of falling was assessed by phone to determine the test-retest reliability of the RPQ when administered by phone.

Results
The RPQ demonstrated excellent test-retest reliability when delivered in person (ICC = 0.78, 95% Confidence Interval, CI: 0.59–0.89) and by phone (ICC = 0.82, 95% CI: 0.65–0.91), good internal consistency (α = 0.78) and adequate construct validity (r = 0.52, 95% CI: 0.20–0.74, p = 0.003) in older adults with DM2.

Conclusion
Given the good psychometric properties in this sample of persons with Diabetes, the RPQ has the potential to be used in clinical practice as a risk assessment and fall prevention tool. However, further testing needs to be done using a larger sample.
Zinc and boron co-doped nanotitania with enhanced photocatalytic degradation of Acid Red 6A under visible light irradiation
Authors: Mulpuri Ravi Kumar , Tirukkovalluri Siva Rao , Imandi Manga Raju , Alim Shaik Abdul , Kapuganti Venkata Divya Lakshmi 
Published: November 2019

AbstractThe present investigation summarizes the synthesis and characterization of zinc and boron co-doped TiO2 nano catalyst by sol gel method at relatively low temperature and explored the optimum reaction parameters for the degradation of Acid Red 6A (AR 6A) under visible light irradiation. The structural, morphological, surface properties of the synthesized photocatalysts were characterized by X-Ray Diffraction, Scanning Electron Microscopy-Energy Dispersive X-ray Spectroscopy, Transmission Electron Microscopy, Brunauer-Emmett-Teller, UV-Vis-Diffuse Reflectance Spectroscopy, X-ray Photo Electron Spectroscopy and Fourier Transform-Infra Red Spectroscopy. The findings of the characterization results revealed that Zn2+ ion was substitutionally doped into TiO2 lattice by replacing Ti4+ ion and a part of the boron substituted the oxygen in TiO2 lattice and the remaining amount was converted to B2O3 due to calcinations at 450 °C. The degradation of AR 6A was achieved at optimum reaction parameters, such as pH = 6 with a catalyst dosage 100 mg L−1 for the degradation of 5 mg L−1 of dye solution.
Modeling competence in science education
Authors: Chiu Mei-Hung , Lin Jing-Wen 
Published: November 2019

AbstractResearch on the understanding of the nature of models and modeling processes in science education have received a lot of attention in science education. In this article, we make five claims about the research on modeling competence in science education. The five claims are (1) the development of modeling competence in practice is essential to scientific literacy for twenty-first century citizens, (2) further research is needed to build a holistic and theoretical understanding of models and modeling knowledge (MMingK), (3) providing a modeling-based scaffolding framework for meaningful and active authentic learning is to enhance student’s engagement of scientific practice, (4) appropriate formative assessment instruments and evaluation rubrics to assess students’ modeling processes and products within the context of modeling practice should be developed, and (5) research on learning progression in modeling competence needs to be intertwined with MMingK and modeling practice. Implications for student learning and teacher professional development will be drawn from existing literature.
Use of serum bilirubin/albumin ratio for early prediction of bilirubin induced neurological dysfunction
Authors: Mosallam Dalia , Said Reem N. , Abd Elsamad Marwa A. , Abdelfatah Nada M. 
Published: December 2019

Abstract
Background
Kernicterus or bilirubin encephalopathy is a preventable cause of handicap, still occurs in our country. The aim of the current study was to assess the role of bilirubin/albumin ratio in improving the morbidity of the cases with unconjugated hyperbilirubinemia and to estimate of the cutoff value for B/A ratio for prevention and early management of bilirubin-induced neurological dysfunction.

Results
The mean gestational age was 37.1 ± 2.11 weeks; the mean age of onset of jaundice was 2.36 ± 1.04 days; the mean level of total bilirubin was 26.14 ± 7.36 mg/dl. At chosen cutoff value of bilirubin albumin ratio (B/A) 6.68, sensitivity was 82% while specificity was 64% and accuracy was 95%.

Conclusion
Bilirubin encephalopathy still occurs in significant number in our country though it is a preventable cause of handicapping. TSB is a sensitive but not a specific indicator of ABE, B/A ratio is more specific indicator of the neurologic outcome and should be utilized in the decision of early intervention.
Rapid affinity purification of intracellular organelles using a twin strep tag
Authors: Xiong Jian , He Jingquan , Xie Wendy P. , Hinojosa Ezekiel , Ambati Chandra Shekar R. , Putluri Nagireddy , Kim Hyun-Eui , Zhu Michael X. , Du Guangwei 
Published: November 2019

ABSTRACT
Cells are internally organized into compartmentalized organelles that execute specialized functions. To understand the functions of individual organelles and their regulations, it is critical to resolve the compositions of individual organelles, which relies on a rapid and efficient isolation method for specific organellar populations. Here, we introduce a robust affinity purification method for rapid isolation of intracellular organelles (e.g. lysosomes, mitochondria and peroxisomes) by taking advantage of the extraordinarily high affinity between the twin strep tag and streptavidin variants. With this method, we can isolate desired organelles with high purity and yield in 3 min from the post-nuclear supernatant of mammalian cells or less than 8 min for the whole purification process. Using lysosomes as an example, we show that the rapid procedure is especially useful for studying transient and fast cellular activities, such as organelle-initiated signaling and organellar contents of small-molecular metabolites. Therefore, our method offers a powerful tool to dissect spatiotemporal regulation and functions of intracellular organelles.
Nonsurgical endodontic management of dens invaginatus: a report of two cases
Authors: Abu Hasna Amjad , Ungaro Daniela Maria de Toledo , de Melo Allana Agnes Pereira , Yui Karen Cristina Kazue , da Silva Eduardo Galera , Martinho Frederico Canato , Gomes Ana Paula Martins 
Published: December 2019

Dens invaginatus is a malformation affecting mainly the superior lateral incisors. It is defined as an infolding of the crown hard tissues, including the enamel and dentin, and can extend up to the root apex. Root canal treatment of this abnormality is considered difficult due to the complex anatomy presented by these teeth. This case series presents nonsurgical endodontic treatment in two cases of dens invaginatus (type II and III) in maxillary lateral incisors. This nonsurgical or conventional endodontic treatment results in healing of the periapical lesions associated with both cases, with no need for extra intervention e.g. surgical or invasive management. The manual instrumentation associated with sodium hypochlorite and calcium hydroxide were able to completely heal the lesions. Radiographic exams were carried out to control and asses the healing. Nonsurgical treatment was successful in both cases with adequate repair after a 6-year follow-up with radiographic and tomographic assessments.
Analysis of Types, Intensity, Methods and Effects of Process Innovations
Authors: Macurová Pavla , Peterková Jindra , Czerná Katarzyna 
Published: December 2019

Purpose: The purpose is to provide knowledge about the intensity and types of process innovation in the business sphere, as well as the representation of entities involved in creating innovation, and about the effects of process innovation.Methodology/Approach: Data from the statistical survey on innovation activities carried out by the Czech Statistical Office according to the Eurostat methodology were used, supplemented by some results of the own questionnaire survey. Methods of sorting, size arrangement, structure analysis, comparison, context analysis were used.Findings: The large enterprises were significantly more active than SMEs in implementing process innovations, as well as foreign affiliates were more active than domestic enterprises. Besides typical competitive advantages of process innovation benefits the benefits in ecology, occupational safety and reduced labour demand have also proved to be numerous. Co-operation of enterprises with universities has proved to be low. The lack of skilled workers and financial resources were the main obstacles to the innovation activity of enterprises.Research Limitation/implication: The research is focused on companies in the Czech Republic.Originality/Value of paper: The actual contribution of the article lies in the purpose-oriented comparison of process innovations between fields of enterprise activities, especially in the area of logistics innovations, in some aspects the comparison of process-innovation activities according to the size of the company and the ownership of the company.
The long-term outcomes of modified Harrington procedure using antegrade pins for periacetabular metastasis and haematological diseases
Authors: Tillman Roger , Tsuda Yusuke , Puthiya Veettil Manoj , Young Peter S. , Sree Deepak , Fujiwara Tomohiro , Abudu Adesegun 
Published: December 2019

Aims The aim of this study was to present the long-term surgical outcomes, complications, implant survival, and causes of implant failure in patients treated with the modified Harrington procedure using antegrade large diameter pins. Patients and Methods A cohort of 50 consecutive patients who underwent the modified Harrington procedure for periacetabular metastasis or haematological malignancy between January 1996 and April 2018 were studied. The median follow-up time for all survivors was 3.2 years (interquartile range 0.9 to 7.6 years). Results The five-year overall survival rate was 33% for all the patients. However, implant survival rates were 100% and 46% at five and ten years, respectively. Eight patients survived beyond five years. There was no immediate perioperative mortality or complications. A total of 15 late complications occurred in 11 patients (22%). Five patients (10%) required further surgery to treat complications. The most frequent complication was pin breakage without evidence of acetabular loosening (6%). Two patients (4%) underwent revision for aseptic loosening at 6.5 and 8.9 years after surgery. Ambulatory status and pain level were improved in 83% and 89%, respectively. Conclusion The modified Harrington procedure for acetabular destruction has low complication rates, good functional outcome, and improved pain relief in selected patients Cite this article: Bone Joint J 2019;101-B:1557–1562
Chemical preparation, thermal behavior and infrared studies of the new cyclotriphosphate tetrahydrate of manganese and distrontium, MnSr2(P3O9)2.4H2O
Authors: EL Makhloufy Smail , Tridane Malika , Majdi El Mehdi , Marouani Hamza , Zerraf Soufiane , Belhabra Mustafa , Cherqaoui Abdelouahed , Belaaouad Said 
Published: November 2019

A new cyclotriphosphate tetrahydrate of manganese and distrontium, MnSr2(P3O9)2.4H2O, was obtained as a polycrystalline sample by the method of ion-exchange resin. The cyclotriphosphate studied in this work is the second one having the formula MnSr2(P3O9)2.4H2O after BaZn2(P3O9)2.10H2O. Its crystallographic characterization, infrared studies and thermal behavior are given. The studied phosphate crystallizes in the triclinic system, P-1, with the following unit cell parameters : a = 6,653(1)Å, b = 7,110(1)Å, c = 5,123(1)Å, a = 103,37(2)°, b = 95,81(2)°, g = 93,04(2)° and Z = 1. The intermediate products of dehydration of MnSr2(P3O9)2.4H2O are MnSr2(P3O9)2.2H2O, mixture of ([Mn(PO3)2]∞ + 2g [Sr(PO3)2]∞) and mixture of ([Mn(PO3)2]∞ + 2b[Sr(PO3)2]∞). The thermal behavior of the studied condensed phosphate has been investigated and interpreted by IR absorption and X-ray diffraction experiments. The title compound can be used as catalyst, ion exchanger, the reactant in ionic conditions, intercalation reactions, superphosphate fertilizer and as an inorganic pigment in ceramics.
The Employment Standards Enforcement Gap and the Overtime Pay Exemption in Ontario
Authors: Thomas Mark P. , Vosko Leah F. , Tucker Eric , Steedman Mercedes , Noack Andrea M. , Grundy John , Gellatly Mary , Leinveer Lisa 
Published: December 2019

Employment Standards (es) legislation sets minimum terms and conditions of employment in areas such as wages, working time, vacations and leaves, and termination and severance. es legislation is designed to provide minimum workplace protections, particularly for those with little bargaining power in the labour market. In practice, however, es legislation includes ways in which legislated standards may be avoided, including through exemptions that exclude specified employee groups, fully or partially, from legislative coverage. With a focus on the Ontario Employment Standards Act, this article develops a case study of exemptions to the overtime pay provision of the act and regulations and examines in closer detail three specific areas in which exemptions apply. Through this study of the overtime pay exemption, the system of exemptions is presented as a contradictory approach to the regulation of es that, in effect, reduces es coverage, contributes to the avoidance of key legislated standards, and undermines the goal of providing protection for workers in precarious jobs.

La Loi sur les normes d’emploi fixe des conditions minimales d’emploi dans des domaines tels que les salaires, la durée du travail, les vacances et les congés, ainsi que les licenciements et les indemnités de départ. Cette loi vise à fournir une protection minimale sur le lieu de travail, en particulier pour ceux qui ont un faible pouvoir de négociation sur le marché du travail. Cependant, dans la pratique, la Loi sur les normes d’emploi comprend des moyens pour éviter les normes législatives, notamment par le biais d’exemptions excluant totalement ou partiellement certains groupes d’employés de la couverture législative. En mettant l’accent sur la Loi sur les normes d’emploi de l’Ontario, cet article élabore une étude de cas sur les exemptions à la disposition de la loi et de ses règlements sur la rémunération des heures supplémentaires et examine plus en détail trois domaines spécifiques dans lesquels les exemptions s’appliquent. Dans cette étude sur l’exemption des heures supplémentaires, le système d’exemptions est présenté comme une approche contradictoire de la réglementation de la Loi sur les normes d’emploi qui, en réalité, réduit sa couverture, contribue à éviter les normes clés définies par la loi et sape l’objectif de protection des travailleurs qui occupent des emplois précaires.
Optimization of a double-pass scheme for thermal de-phasing compensation in high-power second-harmonic generation
Authors: Sabouri Saeed Ghavami , Khorsandi Alireza 
Published: December 2019

The performance of a double-pass scheme is theoretically investigated for the efficiency enhancement of a second-harmonic (SH) beam generated by using a high-power fundamental laser beam. Based on a modified version of coupled equations that include the possible effects leading to the thermal de-phasing, the Collins integral is used for optimizing the focusing optics to obtain maximum efficiency of SH conversion. We found through simulation that at a fundamental power of 40 W, when the focusing regime is set for the loose condition, a conversion efficiency of 74% can be reached. It is possible if the focusing points of the first and second passes are designed to be located at 19 mm and 6 mm away from the input face of the crystal, respectively.
Avaliação da qualidade de água para consumo humano em fonte subterrânea na região do recôncavo da Bahia
Authors: Mendonça Fabiana Costa , Almeida Rafaela Silva , De Oliveira Diego Ferreira , Santos Aldenor Gomes 
Published: December 2019

A água é um dos recursos naturais fundamentais à vida na Terra. É considerada como um bem precioso, indispensável a todas as atividades humanas, além de consistir num componente representativo de valores sociais e culturais. A sua contaminação traduz um grande risco à saúde da população. Este trabalho apresenta a avaliação da qualidade da água para consumo, proveniente da fonte localizada no município de Catu, região do recôncavo da Bahia. As amostras foram coletadas no período de junho a agosto de 2019 em um único ponto, muito utilizada pela população local. Foram analisados parâmetros físico-químicos e microbiológicos tais como: pH, sólidos totais dissolvidos, condutividade, turbidez, cor, ferro, dureza, cloreto, flúor, coliformes totais e termotolerantes. Os valores médios para os parâmetros físico-químicos analisados foram: pH (6,8), sólidos totais dissolvidos (98,88 mg/L), condutividade (154,50 µs/cm), turbidez (0,67 NTU), cor (0,0 mg.Pt/L), ferro (0,04 mg/L), dureza (40 mg/L), cloreto (50,65 mg/L) e flúor (0,07 mg/L). Para os parâmetros microbiológicos foram identificados resultados positivos para coliformes totais e negativos para termotolerantes. Os resultados encontrados foram comparados com os valores de referência estabelecidos pela Portaria nº 2.914/11 do Ministério da Saúde, Resolução CONAMA nº 396/08 e Resolução CONAMA nº 357/05. Os valores encontrados indicaram que todos os parâmetros físico-químicos ficaram em conformidade com as legislações vigentes, no entanto, para a análise microbiológica, os coliformes totais apresentaram valores superiores aos aceitáveis, indicando possíveis contaminação por falta de manutenção.
“Bela Beli Kulonprogo” dan Implikasinya Bagi Peningkatan Kualitas SDM di Industri Batik Sinar Abadi Desa Ngentakrejo
Authors: Musfiroh Wafa Insanul 
Published: December 2019

“Bela Beli Kulonprogo” policy has have come a spirit for entrepreneurship of home industry in Ngentakrejo Village particularly by industry of Batik Sinar Abadi. This spirit is considering for researcher to proved what has used criteria to improved quality of product. For that, this article aims to increase quality of human resources by Sinar Abadi Batik of industry. We conducted a case study approach, the data in this research was collected through interview and field observation process. This context has occurred by Batik Sinar Abadi that implemented new role of the quality product of increase it. Before production of promoted in the market, Sinar Abadi Batik of industry has conducted empleyment criteria to accepted. After that, an employee was given to supporting work harder until synchronous productivity with the company vision. For achievers employment, they are giving reward in the form of money who is supported workers harder by labor. One side, the author was founded new role based on before and after improving human resources. On the other side, the quality of improving those human resources has have given positive impact and increasingly to promotion for region until it shall be branding of village.Kebijakan “Beli Beli Kulonprogo” menjadi spirit para pengelola home industri. Terutama industri Batik Sinar Abadi Desa Ngentakrejo. Spirit ini menyita perhatian peneliti untuk membuktikan kriteria apa saja yang digunakan untuk meningkatkan kualitas produksi tersebut. Untuk itu, artikel ini membahas mengenai peningkatan kualitas sumber daya manusia oleh Industri Sinar Abadi Batik. Dengan menerapkan case study approach, data-data dalam riset ini dikumpulkan melalui proses wawancara dan obervasi lapangan. Oleh karena corak penelitian bersifat narasi deskriptif, peneliti menemukan sebuah kebaruan pada paper ini. Konteks semacam ini terjadi karena industri Batik Sinar Abadi di Desa Ngentakrejo menerapkan pola baru dalam meningkatkan kualitas produknya. Sebelum hasil produksi dipasarkan, industri Sinar Abadi Batik melakukan kegiatan seleksi karyawan. Setelah itu, karyawan yang diterima dilatih (training) disesuaikan dengan job descriptions. Jika sudah mahir, karyawan diberikan support lain untuk terus bekerja lebih giat, sehingga sesuai dengan harapan perusahaan. Bagi karyawan yang berprestasi, mereka diberikan reward berupa uang lembur yang mendorong pembatik lebih baik dalam bekerja. Di satu sisi, penulis menemukan pola perubahan berdasarkan pra dan pasca adanya peningkatan sumber daya manusia. Di sisi lain, peningkatan kualitas sumber daya manusia tersebut memberikan kontribusi positif dan promosi daerah sehingga menjadi branding desa.