bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Collision of Meta-Inflammation and SARS-CoV-2 Pandemic Infection
Authors: Huizinga Gabrielle P , Singer Benjamin H , Singer Kanakadurga 
Published: September 2020

Abstract
The coronavirus disease 2019 (COVID-19) pandemic has forced us to consider the physiologic role of obesity in the response to infectious disease. There are significant disparities in morbidity and mortality by sex, weight, and diabetes status. Numerous endocrine changes might drive these varied responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, including hormone and immune mediators, hyperglycemia, leukocyte responses, cytokine secretion, and tissue dysfunction. Studies of patients with severe COVID-19 disease have revealed the importance of innate immune responses in driving immunopathology and tissue injury. In this review we will describe the impact of the metabolically induced inflammation (meta-inflammation) that characterizes obesity on innate immunity. We consider that obesity-driven dysregulation of innate immune responses may drive organ injury in the development of severe COVID-19 and impair viral clearance.
Techniques for Fostering Self-Regulated Learning Via Learning Management Systems in On-Campus and Online Courses
Authors: Shine Beau , Heath Sarah E. 
Published: September 2020

While self-regulated learning is a standard model for online coursework, this approach emphasizes the applicability of Learning Management System (LMS) usage in face-to-face and hybrid course formats. Self-regulated learning has become an important component of education, both as a primary tool in online coursework and as a supplemental resource in face-to-face courses. (Boekaerts, 1999). Yet despite its importance, research suggests that rather than utilizing the full potential of learning management and course management systems, instructors primarily use LMS and CMS as a delivery mode for course content (Boekarts, 1997; Vovides et al., 2007). Such underutilization not only minimizes the capacities of such systems, but limits the opportunities for students to engage in multimodal self-regulated learning. This paper offers three specific techniques to improve self-regulated learning via LMS: flipped learning, chunking, and micro-learning. Research findings have led to support for each of the above-mentioned techniques (Nwosisi et al., 2016; Miller, 1956; Major & Calandrino, 2018). The authors provide examples of techniques used in their own courses, how each facilitates self-regulated learning, and how utilizing the full capabilities of learning management systems engages students in multimodal self-regulated learning. Common findings and recommendations will also be noted, with the goal of providing a framework for instructors to apply each technique via learning management systems in their own courses.
Comparative analysis of equipment performance in nuclear medicine
Authors: De Paula Vitor Moura , De Sá Lidia Vasconcellos , Braz Delson 
Published: September 2020

To ensure satisfactory equipment performance, image reliability and accurate diagnosis a set of measurements and analysis named as quality control (QC) has to be established. QC is a routine practice where the essential quipment performance or procedure is evaluated by comparing the results to a predefined acceptable range. Currently there are 448 Nuclear Medicine Services (NMS) in Brazil that have to comply with the standards and regulations stablished by Brazilian regulatory agencies the National Nuclear Energy Commission (CNEN) and the National Health Surveillance Agency (ANVISA). Both regualtory bodies have power to control and ensure compliance with their national regulations including quality control tests of equipments to be fulfilled by all NMS operating in Brazil. However, these standards do not establish minimum performance requirements for the most tests and do not guarantee the quality to the population health care. This paper aims to evaluate and analyze the performance limits of the quality control tests in nuclear medicine practice requested in Brazilian standards and compare them with available requirements addressed in international recommendations. Regarding performance limit evaluation many of the requested tests do not address a methodology or minimum performance values to ensure what is considered satisfactory in a quality control test. It was found that Brazilian NMS standards need revision when compared to international recommendations.
Lacan, discurso, acontecimiento (reseña)
Authors: Sánchez Beltrán Carlos Andrés 
Published: September 2020

Reseña:Parker, Ian y Pavón-Cuellar, David (Coord.). Lacan, discurso, acontecimiento. Nuevos análisis de la indeterminación textual. Ciudad de México: Universidad Michoacana de San Nicolás de Hidalgo - Plaza y Valdés Editores, 2013. 429 páginas.
The formation of a sociolinguistic style in translation
Authors: Nakamura Momoko 
Published: September 2020

This paper illustrates the powerful role of translation in creating a sociolinguistic style. Through a quantitative survey of Japanese native speakers and a qualitative analysis of translated speech in an imported TV show and its Japanese parody, the study shows that Japanese translation practices have invented and preserved a widely recognised Japanese style associated with non-Japanese men. The study demonstrates that the style is linked with an image of non-Japanese young men characterised by cool informality; that it is marked by the use of linguistic features not commonly used among native speakers; and that it can be used to enregister a negative stereotype of non-Japanese masculinity, which serves to legitimate a polite, formal, Japanese normative masculinity. The findings suggest that translation is a process in which dominant ideologies of the target-language culture can be reinforced through the voices and bodies of nonnatives.
Women's issues∗
Authors: Keni Ravish , Mostacci Barbara , Kiteva‐Trenchevska Gordana , Licchetta Laura , Ignjatova Liljana , Thomas Sanjeev , Meador Kimford J. 
Published: September 2020

AbstractSpecial considerations are required for women with epilepsy. These include issues such as catamenial exacerbation, concerns for contraception, teratogenesis (including both anatomical and neurodevelopmental effects), and other concerns for pregnancy complications such as increased seizures or adverse obstetric outcomes. In this manuscript, several cases are presented and discussed addressing some of the important issues in the management of women with epilepsy.
RTTBD‐like activity in association with hippocampal ictal discharges in patients with temporal lobe epilepsy
Authors: Sun Taixin , Liu Xi , Issa Naoum P. , Rose Sandra , Wu Shasha , Wang Qun , Martinez Raisa , Towle Vernon L. , Jr Douglas R. Nordli , Warnke Peter , Tao James X. 
Published: September 2020

AbstractAim. To determine clinical and intracranial EEG correlates of rhythmic temporal theta bursts of drowsiness (RTTBD) and assess its clinical significance in patients with temporal lobe epilepsy (TLE).Methods. A retrospective review of simultaneous scalp and intracranial video‐EEG recordings from 28 patients with TLE was evaluated for epilepsy surgery. Scalp RTTBD patterns were identified and their clinical and intracranial EEG correlates were then determined on video‐EEG recording using depth and subdural electrodes.Results. Thirty‐one RTTBD patterns on scalp EEG were observed in six (21%) of the 28 patients. Five (16%) of the RTTBD patterns occurred during wakefulness and 26 (84%) occurred during drowsiness and light sleep. The mean duration of RTTBD was 10 seconds (range: 3‐28 seconds). RTTDB consistently correlated with hippocampal ictal discharges and was time‐locked to the hippocampal seizures in which the ictal discharges evolved into rhythmic theta frequency (4‐7‐Hz) range. Ictal automatisms were observed during five (16%) RTTBD patterns, while cognitive impairment was observed in four (13%) of the 31 RTTBD patterns.Conclusion. Our findings show that scalp EEG correlates of hippocampal ictal discharges can resemble RTTBD and may be associated with ictal symptoms and cognitive impairment, indicating that RTTBD may rarely be an ictal EEG pattern in patients with TLE.
Changes in serum perampanel concentration profile after discontinuation of carbamazepine
Authors: Murugesu Sumitha , Okayama Kiminobu , Yamamoto Yoshiaki , Terada Kiyohito , Takahashi Yukitoshi 
Published: September 2020

AbstractAim. To evaluate changes in the pharmacokinetics of perampanel after discontinuation of carbamazepine.Methods. We enrolled 13 patients receiving perampanel who discontinued carbamazepine therapy between June 2016 and December 2018. Data on serum concentrations were obtained from the therapeutic drug monitoring database of the National Epilepsy Center (Shizuoka, Japan). To compare the pharmacokinetics of perampanel before and after discontinuation of carbamazepine, we determined the concentration/dose (CD) ratio of perampanel (serum level [ng/mL] divided by the dose [mg/kg]). The follow‐up period was set to eight weeks following the discontinuation of carbamazepine therapy.Results. The mean baseline CD ratio of perampanel was 1,247 ng/mL/mg/kg which increased markedly over time after discontinuation of carbamazepine, with a mean CD ratio at Weeks 1‐2, Weeks 3‐4, and Weeks 5‐8 of 2,683, 3,914, and 4,220, respectively. At eight weeks, the mean CD ratio of perampanel had increased by 276%. Eleven patients developed adverse events, including dizziness, somnolence, irritability, and ataxia. Five of these 11 patients required perampanel dose reduction within eight weeks after discontinuation of carbamazepine. Two patients achieved seizure‐free status at Weeks 5‐8.Conclusion. The serum perampanel concentration began to increase from one week after discontinuation of carbamazepine, and continued to rise for eight weeks. Based on these findings, we recommend frequent monitoring of serum perampanel concentration for at least eight weeks after stopping carbamazepine therapy. Monitoring is required as a guide for dose adjustment in order to achieve a safe and effective therapeutic dose of perampanel.
How to diagnose and classify idiopathic (genetic) generalized epilepsies
Authors: Elmali Ayse Deniz , Auvin Stéphane , Bast Thomas , Rubboli Guido , Koutroumanidis Michalis 
Published: September 2020

AbstractIdiopathic or genetic generalized epilepsies (IGE) constitute an electroclinically well‐defined group that accounts for almost one third of all people with epilepsy. They consist of four well‐established syndromes and some other rarer phenotypes. The main four IGEs are juvenile myoclonic epilepsy, childhood absence epilepsy, juvenile absence epilepsy and IGE with generalized tonic‐clonic seizures alone. There are three main seizure types in IGE, namely generalized tonic‐clonic seizures, typical absences and myoclonic seizures, occurring either alone or in any combination. Diagnosing IGEs requires a multidimensional approach. The diagnostic process begins with a thorough medical history with a specific focus on seizure types, age at onset, timing and triggers. Comorbidities and family history should be questioned comprehensively. The EEG can provide valuable information for the diagnosis, including specific IGE syndromes, and therefore contribute to their optimal pharmacological treatment and management.
A clinico-histopathological spectrum of Prostatic lesions at a tertiary care teaching institute
Authors: Krishna Tadepalli 
Published: September 2020

: Prostatic carcinoma is the second most common cause of cancer deaths in men and the incidence is increasing significantly in recent years, due to early screening measures. A study designed to identify the prostatic lesions spectrum as per histopathological classification.: 50 prostatic lesion samples collected in 10% formalin were subjected to H and E stain and the mean AgNOR counts were calculated.: Out of 50 specimens, 80% were benign and 20% belongs to malignancy. The mean age of patient’s benign and malignant lesions is 63.5 ± 9.2 years and 69.5 ± 8.5 years respectively (P=0.09). The most common clinical symptom of benign lesions was frequency in35 patients, followed by hesitancy and nocturia in 33 and 30 patients respectively. Serum PSA values above 10ng/ml were seen in 10 benign cases and 5 malignant cases (P=0.02). Out of 50 cases, 35 were BPH, 5 were non-specific granulomatous prostatitis, 8 prostatic adenocarcinoma, 1 case urothelial carcinoma and 1case with both prostatic adenocarcinoma and urothelial carcinoma were recorded. High grade PIN identified in 9 specimens and low grade PIN identified in 8 specimens. High grade PIN shows association with adenocarcinoma. Basal cell hyperplasia identified in 3 specimens. Tufting Pattern was observed in 2 specimens, flat Pattern observed in 4 specimens, and cribriform pattern observed in 1 specimen out of 9. Majority of patients diagnosed as conventional adenocarcinoma with a score of 9 (3 cases) followed by score of 8 (2 cases).: BHP is the most common non neoplastic prostate lesion, and commonly encountered in age group of 60- 70 years. In the current scenario, histopathological analysis of prostate specimens plays crucial role in both diagnosis and management.
RECOGNITION OF FOSSIL NEBKHA DEPOSITS: CLUES FROM NEOICHNOLOGY AND SEDIMENTOLOGY
Authors: CARDONATTO M. CRISTINA , MELCHOR RICARDO NESTOR 
Published: September 2020

ABSTRACTThis study includes the first neoichnologic characterization of the burrow systems of Tympanoctomys barrerae (Rodentia: Octodontidae) and also considers sedimentologic features of the modern nebkhas where they occur. Tympanoctomys is a South American solitary and fossorial rodent that has ecomorphofunctional adaptations for living in saline environments and constructs its burrow in nebkhas with halophyte shrubs. The purpose of this work is to identify the ichnologic signatures of T. barrerae burrow systems and to provide combined ichnologic-sedimentologic criteria for identification of Cenozoic nebkha deposits. Tympanoctomys barrerae burrow systems are subhorizontal, typically with ten or more entrances, two or three levels, closed circuits, average complexity of 48, average tortuosity of 3.25, and an average ratio of total chamber volume to total tunnel volume of 0.04. The size of the tunnels averages 85 mm in horizontal diameter and 64 mm in vertical diameter, and cross-section shape ranges from elliptical flattened to plano-convex with incipient bilobed floor. Surface ornamentation is typified by a coexistence of primary (sets of four claw traces forming an arcuate pattern produced during digging) and secondary (numerous arthropod burrows excavated from the burrow lumen) surface ornamentation. Nebkha deposits in upper Cenozoic sequences can be recognized by the combination of ichnologic and sedimentologic features: fossil burrows having the ichnologic features characteristic of T. barrerae burrow systems and presence of rhizoliths of shrubby plants occurring in well-sorted sandy deposits with low-angle crossbedding. These criteria can be potentially applied to fossil sequences dating back to the early Oligocene.
Foraminifera in the World Register of Marine Species (Worms) Taxonomic Database
Authors: Hayward Bruce W. , Coze François Le , Vandepitte Leen , Vanhoorne Bart 
Published: September 2020

ABSTRACTMost foraminiferal research is founded on sound taxonomy. To clearly communicate such research, similar species concepts and consistent use of names is desirable. As a contribution to this larger goal, the World Foraminifera Database (http://www.marinespecies.org/foraminifera) was set up in 2010 as a subset within the World Register of Marine Species (WoRMS). The purpose is to provide an authoritative, open-access inventory of all foraminiferal taxonomic names. The inventory is almost complete for both fossil and Recent foraminiferal taxa, containing 4932 generic and 55,884 species (including infraspecies) names. There are ∼61,000 genus-species combinations of which ∼54,600 are currently “accepted” species and infraspecies (with 9600 extant). Associated data includes 14,700 linked foraminiferal literature sources, ∼6600 images, and species-level links to many other databases and images, such as the Cushman Collection (Smithsonian Institution), American Museum of Natural History, Mikrotax (planktic foraminifera), GenBank, and Zootaxon. The WoRMS database is owned by the global taxonomic community and hosted and serviced by the Flanders Marine Institute (VLIZ), Belgium. We recommend that all researchers working with foraminifera both use and contribute to the World Foraminifera Database, as that will improve the accuracy of the database's content and save investigators many hours of searching elsewhere.
Application of an Improved Ant Colony Algorithm to Optimal Path Planning for Automatic Guided Vehicles
Authors: zhu weikang , liu jicheng 
Published: September 2020

Abstract
The path planning is the key technology of AGV path finding. This paper uses an improved ant colony algorithm to plan the path of an AGV. For avoiding the defects of traditional ant colony algorithm such as low smoothness of route and local optimal solution, the transition probability and pheromone update method are improved. Various actual turning situations are analyzed in the transition probability, the basis for defining the smoothing factor is provided by the Bezier curve, and a random selection operator is formed for updating local pheromone by extracting characteristic information of iterative process. The simulation results in different environments prove that the smoothing factor plays an important role in optimizing the smoothness of the path and the diversity of the constructed solutions, and the random selection operator is effective in solving the contradiction of the local optimal solution and in finding the optimal solution.
Student Satisfaction with Videoconferencing Teaching Quality During the COVID-19 Pandemic
Authors: Fatani Tarah 
Published: September 2020

Abstract
Background: The coronavirus disease 2019 pandemic prompted the pediatric department at King Abdulaziz University to continue students’ educational activities by offering courses online that utilized web video conferencing (WVC). Given the uncertainties of WVC educational quality and the challenge of shifting to an online environment, this study aimed to evaluate student satisfaction with the teaching quality of case-based discussion (CBD) sessions conducted through WVC.Methods: 162 undergraduate medical students in pediatrics completed the reduced Students’ Evaluation of Educational Quality (SEEQ) survey with a five-point Likert scale over 5 weeks. The WVC CBD sessions were facilitated by 50 faculty members. Results: 82% of respondents were highly satisfied with the WVC CBD session’s teaching quality. The majority agreed that the sessions were intellectually challenging, that the instructors were dynamic, and encouraged students to participate. No statistically significant correlation was found between student satisfaction and technical issues (r = 0.037, p = 0.003).Conclusions: WVC teaching had an overall positive outcome on student satisfaction, and teaching quality relied on teaching, cognitive, and social presence rather than technology. However, technology remains an important platform that supports teachers’ educational activities. Thus, implementing a blended pediatric course to augment future course delivery is optimal.
Crystallization pathways, morphologies and structural defects of α-MnO2 nanomaterial synthesized under annealed temperatures
Authors: Dinh Van-Phuc , Luu Anh Tuyen , Krzysztof Siemek , Kozlenko Denis , Khiem Le , Dang Nguyen Toan , Nguyen Van Tiep , Nguyen Le-Phuc , Tran Duy Tap , Phan Trong Phuc , Lo Thai Son , Anh Tuan Kiet Hoang , Dinh Thanh Khan , Luong Thuy Ngoc , Le Ngoc-Chung , Nguyen Ngoc-Tuan , Ho Thien-Hoang , Tran Dong Xuan , Nguyen Quang Hung 
Published: September 2020

Abstract
Manganese dioxide, in particular α-MnO2, is one of the advanced inorganic nanomaterials having wide applications in many areas. Hence, understanding the crystallization pathways, morphologies, and formation mechanism of defects in its structure is of particular importance, not only for fundamental science but also for practical applications. Herein, different physically and chemically based methods, such as Neutron Diffraction (ND), XRD, SEM, TPR- H2, TGA-DSC, FT-IR, Positron Annihilation Lifetime (PAL), Doppler Broadening (DB) of positron annihilation radiation, and Electron-Momentum Distribution (EMD) measurements combined with theoretical calculations, were utilized to systematically investigate the composition, structure, and morphology of α-MnO2 nanomaterial under different annealed temperatures. The investigated material was synthesized at room temperature using a facile chemical method with potassium permanganate (KMnO4) and ethanol (C2H5OH), prior to being treated by temperatures of 100 oC – 800 oC. Results demonstrated, for the first time, that the α-MnO2 nucleation can be formed even at room temperature and gradually developed to α-MnO2 nanorods at 600 oC. This novel finding, which cannot be explored by conventional XRD, was confirmed by ND analysis. In addition, PAL analysis combined with theoretical ab initio calculations indicated the existence of H+ ions in the tunnel [1x1] of α-MnO2. At the same time, DB and EMD measurements explored the presence of Mn and O vacancies in α-MnO2 crystals at low temperatures. Finally, the present study reported a remarkable finding that organic molecules may act as reactants as well as templates, which are entirely decomposed and disappeared at highly annealed temperatures.
A Bayesian Time-to-event Pharmacokinetic Model for Sequential Phase I Dose-escalation Trials with Multiple Schedules
Authors: Günhan Burak Kürsad , Weber Sebastian , Seroutou Abdelkader , Friede Tim 
Published: September 2020

Abstract
Background: Phase I dose-escalation trials constitute the first step in investigating the safety of potentially promising drugs in humans. Conventional methods for phase I dose-escalation trials are based on a single treatment schedule only. More recently, however, multiple schedules are more frequently investigated in the same trial.Methods: Here, we consider sequential phase I trials, where the trial proceeds with a new schedule (e.g. daily or weekly dosing) once the dose escalation with another schedule has been completed. The aim is to utilize the information from both the completed and the ongoing dose-escalation trial to inform decisions on the dose level for the next dose cohort. For this purpose, we adapted the time-to-event pharmacokinetics (TITE-PK) model, which were originally developed for simultaneous investigation of multiple schedules. TITE-PK integrates information from multiple schedules using a pharmacokinetics (PK) model. Results: In a simulation study, the developed appraoch is compared to the bridging continual reassessment method and the Bayesian logistic regression model using a meta-analytic-prior. TITE-PK results in better performance than comparators in terms of recommending acceptable dose and avoiding overly toxic doses for sequential phase I trials in most of the scenarios considered. Furthermore, better performance of TITE-PK is achieved while requiring similar number of patients in the simulated trials. For the scenarios involving one schedule, TITE-PK displays similar performance with alternatives in terms of acceptable dose recommendations. The R and Stan code for the implementation of an illustrative sequential phase I trial example is publicly available (https://github.com/gunhanb/TITEPK sequential).Conclusion: In sequential phase I dose-escalation trials, the use of all relevant information is of great importance. For these trials, the adapted TITE-PK which combines information using PK principles is recommended.