bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of clinical usefulness of serum Ca125 and CA19-9 in pancreatic adenocarcinoma diagnosis: meta-analysis and systematic review of literature.
Authors: Skulimowski Aleksander , Durczyński Adam , Strzelczyk Janusz , Hogendorf Piotr 
Published: April 2020

Abstract
Background: Pancreatic adenocarcinoma remains one of the most lethal cancers. This is caused by its late manifestation and lack of extensively available, highly accurate diagnostic tools. The only recommended biomarker CA19-9 proves to be not accurate enough to establish a certain diagnosis. Therefore a standardization of usefulness of other biomarkers is essential. Consequently, our aim was to assess the specificity and sensitivity of Ca125 in comparison with CA19-9 by means of meta-analysis. The systematic review of combined tests (CA19-9+Ca125) was also carried out. Methods: We conducted a systematic search of Medline (via PubMed) and Ovid. After screening of abstracts and the assessment of full-texts, 9 studies (number of patients, n = 1599) were included in the meta-analysis. Hierarchical summary receiver under operator curve (hsROC) model was applied to estimate the diagnostic accuracy. Results: CA19-9 sensitivity and specificity were 0,748 (95%CI 0,676-0,809) and 0,782 (95%CI 0,716-0,836) respectively. These values were estimated on 0,593 (95%CI 0,489-0,69) and 0,754 (95%CI 0,817-0,668) for Ca125. Regarding the heterogeneity of studies we found a strong threshold effect for Ca125 and moderate one for CA19-9. Conclusions: Our meta-analysis did not prove the superiority of Ca125 in diagnosis of pancreatic adenocarcinoma. It should be nevertheless noted that analysed studies are encumbered with high heterogeneity mainly due to threshold effect. Moreover the sparsity of studies precludes accurate analysis of various factors’ influence. Therefore further research into Ca125 is warranted to fully elucidate its usefulness. The review of proposed combined tests shows that although CA19-9+Ca125 models are characterized by higher sensitivity, their usefulness is hampered by inferior specificity to than that of CA19-9 alone.
Reliability and application of the new morphological classification system for chronic symptomatic osteoporotic thoracolumbar fracture
Authors: Hao Ding-Jun , Yang Jun-Song , Tuo Yuan , Ge Chao-Yuan , He Bao-Rong , Liu Tuan-Jiang , Huang Da-Geng , Jia Shuai-jun , Liu Peng , Zhang Jia-Nan , Du Jin-Peng 
Published: April 2020

Abstract
ObjectiveThis study proposed a new classification system for Chronic Symptomatic Osteoporotic Thoracolumbar Fracture (CSOTF) based on fracture morphology. Research on CSOTF has increased in recent years. However, the lack of a standard classification system has resulted in inconveniences regarding communication, research and treatment. Previous studies of CSOTF classification exhibit different defects, and none of these studies are widely accepted.MethodsWe collected 368 cases of CSOTF in our hospital from January 2010 to June 2017 and systematically analyzed the imaging data of all patients to develop a classification system. Imaging examinations included dynamic radiography, computed tomography scans and magnetic resonance imaging. Ten investigators systematically studied and fully understood the classification system grading 40 cases on two occasions, examined 1 month apart. Kappa coefficients (κ) were calculated to determine intraobserver and interobserver reliability.ResultsThe new classification system for CSOTF was divided into types I-V according to whether the CSOTF exhibited dynamic instability, spinal stenosis or kyphosis deformity. Intra- and interobserver reliability were excellent for all types (κ = 0.83 and 0.85, respectively).ConclusionsThe new classification system for CSOTF demonstrated excellent reliability in this initial assessment. The system is convenient for communication and research, but wide clinical application are needed to confirm its effectiveness and guide clinical treatment.
The Pearl River Declaration: a timely call for enhancing health security through fostering a regional One Health collaboration in the Asia-Pacific
Authors: Alam Noore , Chu Cordia , Li Qianlin , Crook Allison , Whittaker Maxine , Aditama Tjandra , Schak Elena , Budiman Dicky , Barber Bonnie , Lu Jiahai 
Published: April 2020

Abstract
The Second International Symposium on One Health Research (ISOHR) was held in Guangzhou city, China on 23–24 November 2019. A transdisciplinary collaborative approach, One Health (OH), was the central theme of the symposium which brought together more than 260 experts, scholars and emerging researchers from human health, veterinary health, food safety, environmental health and related disciplines and sectors. More than 50 organizations including World Health Organization, Centers for Disease Control (USA), and Queensland Government (Australia) participated in the symposium. Scholars, experts and emerging researchers, policy-makers and practitioners in their respective fields delivered over 50 presentations at the symposium, highlighting the collective vulnerability to some of the emerging health challenges the region was combating. These included emerging infectious diseases, antimicrobial resistance, climate change, food safety and the growing burden of non-communicable diseases. The Pearl River Declaration, emanated from the symposium, called for establishing a One Health Cooperation Network in the Southeast Asia–Pacific region with a vision to strengthen regional health security through sharing each other’s knowledge and experience, and making investments in workforce development, scientific innovations such as vaccine research and development, sharing epidemic intelligence, risk identification, risk communication and appropriate response measures against emerging health threats.
Effects of adipose-derived stromal cells and endothelial progenitor cells on adipose transplant survival and angiogenesis
Authors: Zhao Xian , Gan Fengshan , Liu Liu , Zhou Qingzhu , Huang Wenli , Huang Xinwei 
Published: April 2020

Abstract

Background: A paracrine mechanism is thought to mediate the proangiogenic capacity of adipose-derived stromal/stem cells (ASCs). However, the precise mechanism by which ASCs promote the formation of blood vessels by endothelial progenitor cells (EPCs) is unclear.Methods: We cocultured ASCs with EPCs at various concentrations to study the effects on angiogenesis. The supernatant from cultured ASCs was cocultured with EPCs to evaluate the effects on the expression of vascular endothelial markers in EPCs, as well as capacity for migration and invasion. We then mixed ASCs with EPCs and transplanted them with adipose tissue into New Zealand white rabbits to evaluate the effects on angiogenesis in adipose tissue grafts.Results: As the relative abundance of ASCs cocultured with EPCs increased, the rate of angiogenesis among EPCs decreased. The supernatant from ASC cultures increased the migration and invasion of EPCs and upregulated the expression of vascular endothelial markers in EPCs. In vivo, ASCs promoted the production of blood vessels by EPCs.Conclusions: ASCs are not recruited as structural components of blood vessels but do appear to regulate endothelial progenitor-mediated angiogenesis. The results obtained show that ASC paracrine signaling promotes the formation of blood vessels by EPCs. ASC paracrine signaling appears to promote angiogenesis by increasing the migration and invasion of EPCs and simultaneously upregulating the expression of vascular endothelial markers in EPCs. The results of in vivo experiments showed that ASCs promote the formation of blood vessels in EPC cultures.
Finite element analysis of double-plate fixation using reversed locking compression-distal femoral plates for Vancouver B1 periprosthetic femoral fractures
Authors: Takahashi Daisuke , Noyama Yoshihiro , Asano Tsuyoshi , Shimizu Tomohiro , Irie Tohru , Terkawi Mohamad Alaa , Iwasaki Norimasa 
Published: April 2020

Abstract
Background: Internal fixation is recommended for treating Vancouver B1 periprosthetic femoral fractures. Although several fixation procedures have been developed with high fixation stability and union rates, long-term weight-bearing constructs are still desired. Therefore, the aim of the present study was to evaluate the stability of a double-plate procedure using reversed contralateral locking compression-distal femoral plates for fixation of Vancouver B1 periprosthetic femoral fractures under full weight-bearing conditions.Methods: Single and double fixation procedures for locking compression-distal femoral plates were analysed under an axial load of 1,500 N by finite element analysis and biomechanical loading tests. A vertical loading test was performed to the prosthetic head in biomechanical testing, and the displacements and strains were calculated based on load-displacement and load-strain curves generated by the static compression tests.Results: Double-plate fixation significantly reduced stress concentration at the fracture site of the lateral plate by finite element analysis. Under full weight-bearing conditions, the maximum von Mises stress in the lateral plate was 268 MPa. On the other hand, maximum stress in the single-plating method occurred at the defect level of the femur with a maximum stress value of 1,303 MPa. The principal strains of single- and double-plate fixation were0.63% and 0.058%, respectively. Consistently, in the axial loading test, the strain values at 1,500 N loading of the single- and double-plate fixation methods were 1,274.60 ± 11.53 and 317.33 ± 8.03 (X 10-6), respectively.Conclusions: The present study suggests that dual-plate fixation with reversed locking compression-distal femoral plates may be an excellent treatment procedure for patients with Vancouver B1 fractures, providing full weight-bearing in the early postoperative period.
Persistence and Remission of Depressive Symptoms and Psycho-Social Correlates in Chinese Early Adolescents
Authors: Chi Xinli , Becker Benjamin , Yu Qian , Hossain M Mahhub , Lin Jingyaun , Yeung Albert , Seiler-Ramadas Radhika , Grabovac Igor , Bu He , Xie Fei , Zou Liye 
Published: April 2020

Abstract
Background: This study aimed to investigate a one-year course of persistent/remitted depressive symptoms and associated demographic and psychosocial factors that predict persistent/remitted depressive symptoms in Chinese high school students.Methods: 1,544 Grade 7 students provided data for the first wave. Of the initially recruited students, 483 who were classified as depressed (CESD score ≥ 16) at baseline were then tracked and invited to fill in the questionnaire for a second time (Grade 8) after one year. Finally, 435 of them were successfully matched.Results: 202 (46.4%) of the subset categorized as depressed in the first survey (N=435) remained with depressive symptoms, while 233 (53.6%) recovered from depression one year later. Having siblings, a lower level of positive youth development, non-intact family status, and poor family functioning at baseline significantly predicted a higher likelihood of persistent depression, while those with fathers having higher educational qualifications (bachelor’s degree or higher) at baseline showed a significantly higher probability of remitting from depression.Limitations: This study used the self-reporting approach without tracking the long-term developmental trajectories of adolescent depressive symptoms. Conclusion: The findings indicated that the prevalence of persistent depressive symptoms was generally high, and promoting aspects of positive youth development and family functioning for adolescents could be promising in preventing or reducing these symptoms.
The prevalence of rheumatoid arthritis in middle-aged and elderly people in Tibet Autonomous Region of China
Authors: Lin Jianhao , Zhang Qing Xi , Liu Qiang , Lin Chu Tong , Baima Yangjin , Li Hu , Gong Hong Qiang 
Published: April 2020

Abstract

Objective

There has been no epidemiological survey of it in Tibet. We estimated the prevalence of rheumatoid arthritis in Luoma Town, Naqu City, Tibet Autonomous Region of China.
Methods

A population-based cross-sectional survey was conducted among 1458 residents of Luoma Town, Tibet Autonomous Region, aged ≥ 40 years. We used questionnaires in face-to-face interviews, anthropometric measurements and rheumatoid factor (RF), autoantibodies binding to citrullinated antigens (ACPA) and C-reactive protein (CRP) test. The definition of rheumatoid arthritis in this study was on the basis of new 2010 ACR/EULAR classification criteria.
Results

782 participants completed all items of rheumatoid arthritis. The overall crude prevalence of rheumatoid arthritis was 4.86%. The prevalence was higher in women than in men (7.14% vs. 2.56%, P = 0.005). Tibetan had a higher age-standardized prevalence of rheumatoid arthritis 6.30% (95% confidence interval: 4.20% − 8.64%) compared with the other areas in China (range: 0.20% − 0.93%).
Conclusion

The prevalence of rheumatoid arthritis is relatively higher than other places in China.
BCI training effects on chronic stroke correlate with functional reorganization in motor-related regions: A concurrent EEG and fMRI study
Authors: Tong Kai Yu , Yuan Kai , Chen Cheng , Wang Xin , Chu Winnie Chiu-wing 
Published: April 2020

Abstract

Background: Brain-computer interface (BCI) guided robot-assisted training strategy has been increasingly applied to stroke rehabilitation, while few studies have investigated the neuroplasticity change and functional reorganization after intervention from multi-modality neuroimaging perspective. The present study aims to investigate the hemodynamic and electrophysical changes induced by BCI training using functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) respectively, as well as the relationship between the neurological changes and motor function improvement. Method: 14 chronic stroke subjects received 20 sessions of BCI-guided robot hand training. Simultaneous EEG and fMRI data were acquired before and immediately after the intervention. Seed-based functional connectivity for resting state fMRI data and effective connectivity analysis for EEG were processed to reveal the neuroplasticity changes and interaction between different brain regions. Moreover, the relationship among motor function improvement, hemodynamic changes and electrophysical changes derived from the two neuroimaging modalities were also investigated. Results: This work suggested: (a) significant motor function improvement could be obtained after BCI training therapy; (b) training effect significantly correlated with functional connectivity change between ipsilesional M1 (iM1) and contralesional Brodmann area 6 (including premotor area (cPMA) and supplementary motor area (SMA)) derived from fMRI; (c) training effect significantly correlated with information flow change from cPMA to iM1 and strongly correlated with information flow change from SMA to iM1 derived from EEG; (d) consistency of fMRI and EEG results illustrated by the correlation between functional connectivity change and information flow change. Conclusions: Our study showed changes in the brain after the BCI training therapy from chronic stroke survivors and provided a better understanding of neural mechanisms, especially the interaction among motor-related brain regions during stroke recovery. Besides, our finding demonstrated the feasibility and consistency of combining multiple neuroimaging modalities to investigate the neuroplasticity change. This study was registered at https://clinicaltrials.gov (NCT02323061) on 23 December 2014.
Protocol for a systematic review and network meta-analysis of randomised controlled trials examining the effectiveness of early parenting interventions in preventing internalising problems in children and adolescents.
Authors: Costantini Ilaria , Paul Elise , Caldwell Deborah M , López-López José A , Pearson Rebecca M 
Published: April 2020

Abstract
Background: Internalising problems, such as depression and anxiety, are common and represent an important economical and societal burden. The effectiveness of parenting interventions in reducing risk of internalising problems in children and adolescents has not yet been summarised. The aims of this review are to:1. assess the effectiveness of parenting interventions in the primary, secondary and tertiary prevention of internalising problems in children and adolescents;2. determine which intervention components and which intervention aspects are most effective for reducing risk of internalising problems in children and adolescents. Methods: Electronic searches in OVID SP versions of Medline, EMBASE and PsycINFO; Cochrane Central Register of Controlled Trials; EBSCO version of ERIC and clinicaltrials.gov have been performed to identify randomised controlled trials or quasi-randomised controlled trials of parenting interventions. At least two independent researchers will assess studies for inclusion and extract data from each paper. The risk of bias assessment will be conducted independently by two reviewers using the Cochrane Collaboration’s Risk of Bias Assessment Tool. Statistical heterogeneity is anticipated given potential variation in participant characteristics, intervention type and mode of delivery, and outcome measures. Random effects models, assuming a common between-study variability, will be used to account for statistical heterogeneity. Results will be analysed using a network meta-analysis (NMA). If appropriate, we will also conduct a component-level NMA, where the ‘active ingredients’ of interventions are modelled using a network meta-regression approach.Discussion: Preventing and reducing internalising problems could have major beneficial effects at the economic and societal level. Informing policy makers on the effectiveness of parenting interventions and on which intervention’s component is driving the effect is important for the development of treatment strategies. Systematic review registration: International Prospective Register for Systematic Reviews (PROSPERO) number CRD42020172251
High-viscosity bone cement for vertebral compression fractures: a prospective study on intravertebral diffusion of bone cement
Authors: wang meiyong , jin qunhua 
Published: April 2020

Abstract
Objective: Bone cement leakage causes severe complication following percutaneous vertebroplasty. This study probed the diffusion and leakage status of bone cement injected within diverged time duration, so as to find the optimal injection time for bone cement. Methods: A total of 70 patients with osteoporotic vertebral compression fractures with a symptom of low back pain, who underwent treatment at hospital were enrolled in this study. Patients were randomized into three groups: <180 s, 180-300, and >300 s of injection time duration from the beginning to the completion of the injection. The scenarios of vertebral bone cement leakage and diffusion were inspected using postoperative CT.Results: The diffusion coefficient was higher in group A than in group B whereas it was higher in group B than in group C, but without statistical significance among the three groups. The leakage rate was without statistical significance among the three groups. The injection time of bone cement was negatively correlated with the diffusion coefficient, at the correlation coefficient of -0.253. Conclusions: The diffusion coefficient of high-viscosity bone cement is likely negatively correlated with the injection time, and the leakage rate of high-viscosity bone cement probably does not reduce with the prolongation of injection time.
Development of Adhesion Force Evaluation Equipment for Nano Diamond Coated Tool Using Shear Method
Authors: Li Jinghua , Lee SoJin , Kweon HyunKyu 
Published: April 2020

Abstract
In this study, we have developed a thin film adhesion evaluation system for diamond coating tool, which is mainly used for CFRP processing, which is widely used in aviation and automobile industries. Carbon fiber reinforced plastic (CFRP), which is a composite material is widely used for high efficiency and light weight in the aerospace industry and automobile industry. CFRP has a low specific gravity and a high specific strength. However, it has difficulty in processing because it has difficulty property. In order to cope with this problem, CFRP is processed using a diamond coating tool with a higher surface hardness. Because of the high surface hardness of the diamond coating tool, it is difficult to evaluate the adhesive strength of the tool, and it is difficult to quantitatively evaluate the existing adhesion force evaluation method and it is costly. This study has developed an evaluation method to measure the adhesive force based on the data of the grinding process using a low cost polishing pad. When the frictional force and the shearing force are applied to the specimen by the sanding belt, friction is continuously generated between the coating layer and the belt, and peeling occurs at the moment when a specific load is applied. Acceleration, load, and torque values that occur during each experiment are collected through acceleration sensors, load cells, and torque sensors. The data obtained through the experiments are subjected to FFT processing and analysis. As a result, the peeling point and the critical load value at this point are identified and referred to as the adhesion force of the coating layer.
Microbiability of meat quality and carcass composition traits in swine
Authors: Khanal Piush , Maltecca Christian , Schwab Clint , Fix Justin , Tiezzi Francesco 
Published: April 2020

Abstract
BackgroundSwine gut microbiome constitutes a portion of the whole genome and has potential to affect different phenotypes. More recently, research is more directed towards association of gut microbiome and different traits in swine. However, the contribution of microbial composition to the phenotypic variation of meat quality and carcass composition traits in pigs has not been explored yet. The objectives of this study are to estimate the microbiabilities for different meat quality and carcass composition traits; to investigate the impact of intestinal microbiome on heritability estimates; to estimate the correlation between microbial diversity and meat quality and carcass composition traits; and to estimate the microbial correlation between the meat quality and carcass composition traits in a commercial swine population.ResultsThe contribution of the microbiome to carcass composition and meat quality traits was prominent although it varied over time, increasing from weaning to off test for most traits. Microbiability estimates of carcass composition traits were greater than that of meat quality traits. Among all of the traits analyzed, belly weight had higher microbiability estimate (0.29 ± 0.04). Adding microbiome information did not affect the estimates of genomic heritability of meat quality traits but affected the estimates of carcass composition traits. Fat depth had greater decrease (10%) in genomic heritability. High microbial correlations were found among several traits. This suggested that genomic correlation was partially contributed by genetic similarity of microbiome composition.ConclusionsResults indicate that better understanding of microbial composition could aid the improvement of complex traits, particularly the carcass composition traits in swine by inclusion of microbiome information in the genetic evaluation process.