bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of a 3-month nutrition intervention on dietary habits and weight change in hospitalized schizophrenic patients with metabolic syndrome
Authors: Soric Tamara , Mavar Mladen , Rumbak Ivana 
Published: June 2020

AbstractIntroduction: Schizophrenic patients are more likely to develop metabolic syndrome (MetS) than the general population. Although the exact reasons for higher MetS prevalence are not yet been fully determined, poor dietary habits may contribute to its development. This study aims to examine the effects of a 3-month nutrition intervention on dietary habits and weight change in hospitalized schizophrenic patients with MetS.Materials and Methods: Seventy-nine hospitalized schizophrenic patients with MetS (aged 18–67) were enrolled in a 3-month randomized controlled trial. Sixty-seven of initially enrolled patients (84.8%) completed the intervention. Participants were randomly assigned to an intervention group (IG; n = 33) or a control group (CG; n = 34). The IG followed the DASH diet (-400 kcal/day when compared to regular hospital diet), the CG continued being on a regular hospital diet (2200–2400 kcal/day), while both groups participated in a nutrition educational program (4 lectures about the development of healthier eating habits). Prior and after the intervention, body weight (BW) was measured and dietary habits were assessed using the nutrition section of Dlugosch & Krieger's General Health Behaviour Questionnaire. Participants also kept a diary of food individually purchased.Results: Nutrition intervention positively modulated the dietary habits and BW of both groups. After 3 months, in the IG, the consumption of white bread (p < 0.001), pastries (p < 0.001), cured meat products (p < 0.001), sweets (p = 0.003), and carbonated soft drinks (p = 0.009) significantly decreased, while the consumption of whole-wheat bread (p < 0.001), fruits (p < 0.001), nuts (p < 0.001), and vegetables (p < 0.001) significantly increased, when compared to the baseline data. Simultaneously, in the CG, the identified modifications mainly referred to a decreased consumption of snacks (p = 0.042) and fast food (p = 0.005), together with an increased consumption of low-fat milk and dairy products (p = 0.019) and vegetables (p = 0.003). Furthermore, results have shown that, compared to the CG, IG significantly improved dietary habits by decreasing the consumption frequency of white bread (p < 0.001), cured meat products (p < 0.001), and sweets (p = 0.043), while at the same time significantly increasing the consumption frequency of whole-wheat bread (p < 0.001), low-fat milk and dairy products (p < 0.001), fruits (p < 0.001), nuts (p < 0.001), and vegetables (p < 0.001). After 3 months, BW significantly decreased in IG (p < 0.001) and CG (p = 0.018), but with no significant difference between respective groups (p = 0.943).Discussion: The findings suggest that this type of a 3-month nutrition intervention could be a valuable tool for an improvement of dietary habits and potentially an add-on therapy to reduce the MetS prevalence and the overall cardiovascular risk in schizophrenic patients.
Effect of birth of child in the household on changes over 7 years in dietary intake and weight of adults
Authors: Méjean Caroline , Rollet Pascaline , Hassen Wendy Si , Tichit Christine , Lampuré Aurélie , Hercberg Serge , Touvier Mathilde , Castetbon Katia 
Published: June 2020

AbstractIntroductionOver the life course, transitions such as parenthood are described in sociological studies as periods of change in attitudes and health practices. The presence of children has been shown to modify adult dietary practices and daily timing of eating occasions, and that the arrival of a child in the household is perceived by parents to be related to changes in their dietary behaviors. Nevertheless, no epidemiological study has evaluated the impact by a longitudinal approach. The objective of our study was to assess the effect of the birth of a first child in a household on dietary intake and weight of adults over a 7-year follow-up period.Materials and MethodsThis study was conducted in 3955 adults included in the NutriNet-Santé cohort study between 2009 and 2010. At baseline and every year, dietary intakes were assessed using 24 h records. In this sample, 185 individuals experienced the birth of a first child in their household during the 7 years of follow-up. Changes in weight, assessed by self-administered questionnaire each year, were analyzed only in women (n = 115). Repeated measures of dietary intake and weight were analysed using mixed models adjusted for sex, age, education level and energy with random effects of time and period (before and after birth of the child) to assess changes following the life event.ResultsThe birth of a first child in the household was associated with a decrease in the score of adherence to French recommendations (PNNS score, β [95% CI] = -0.45 [-0.74; -0.16]), in intakes of fruits and vegetables, meat and processed meat, and vitamin C (respectively, β = -0.30 [-0.43; -0.17]); β = -0.20 [-0.32; -0.17]); β = -0.54 [0.88; -0.19])). The birth of a first child in the household was also associated with an increase in intakes of saturated fatty acids and sodium (respectively, β = 1.49 [0.51, 2.45]); β = 0.31 [0.20; 0.43])). The birth of a first child was associated with weight gain in women (β = 1.70 [1.07, 2.33]).ConclusionOur study has shown that the birth of a first child in the household was associated with rather unhealthy dietary changes. These results could be used to guide public health interventions by focusing on this specific life transition.
Low sleep and diet quality impact on well-being among Mexican college students
Authors: Zeron-Rugerio Maria Fernanda , Ortega-Regules Ana Eugenia , Porras-Loaiza Maria Armida Patricia , Longo-Silva Giovana , Cambras Trinitat , Izquierdo-Pulido Maria 
Published: June 2020

AbstractIntroductionUnderstanding health behaviors, such as sleep and dietary patterns, is important for health promotion and disease prevention. College period is a complicated, difficult time to maintain healthy behaviors. In this regard, little is known about the impact of sleep and diet quality on well-being among college young adults. Hence, we aimed to study the impact of sleep and diet quality on well-being in college students.Materials and MethodsThree hundred-twelve Mexican college students (82% females; 20.6 ± 3.4years) were included in a cross-sectional study. Participants completed the following validated questionnaires: Well-being Index to assess well-being (high scores indicate high well-being), Pittsburg Sleep Quality Index for sleep quality (scores > 5 indicate poor sleep quality), and a validate version of the Health Eating Index for Mexican population to assess diet quality (scores > 80 indicate good diet quality). BMI and physical activity were also assessed. Scores were treated as continuous variables, and statistical analysis were performed using SPSS v24 and adjusted for confounding variables.ResultsSixty-seven percent of our population showed a poor sleep quality and eighty-four percent needs to make changes in their diet in order to improve its quality. On the other hand, fifty-one percent of the studied population had a low well-being perception. Poor sleep quality (p < 0.001) and low diet quality (p < 0.001) associated with a lower well-being perception. In addition, poor sleep quality is associated with low diet quality (p < 0.05). Regarding food consumption, higher sweets (p < 0.001) and soft-drink (p < 0.001) intake was inversely associated with well-being scores. Likewise, high consumption of sweets (p < 0.05) and soft-drink (p < 0.05), and low fruit (p < 0.05) and cereal (p < 0.05) consumption are linked to poor sleep quality.DiscussionOur results show that half of the studied population had a low well-being, and also that poor sleep and diet quality are frequent among college students. Interestingly, the fact that poor sleep and diet quality were associated to a lower perception of well-being highlights the importance of promoting sleep hygiene and diet quality among college students as an important strategy to improve well-being and health, even in young adults. In addition, we found that higher sweets and soft-drink consumption were associated to both low well-being perception and poor sleep quality. Hence, it is important to promote healthy habits regarding eating and sleeping well, in order to improve well-being perception among college students.
Association of pre-pregnancy BMI with biochemical profile during pregnancy, delivery mode and size of neonates in the CRIBS birth cohort
Authors: Havaš Auguštin Dubravka , Šarac Jelena , Zajc Petranović Matea , Novokmet Natalija , Dolanc Ivan , Carić Tonko , Demerath Ellen , Cameron Noel , Missoni Saša 
Published: June 2020

AbstractIn the last few decades the prevalence of overweight and obesity has reached epidemic levels worldwide affecting over 2.1 billion people, including a large proportion of women of childbearing age. An adverse intrauterine environment resulting from conditions such as maternal obesity or gestational diabetes, can have long-term negative effect on the child's health later in life. This study focuses on maternal pre-pregnancy BMIs and their association with biochemical profile in pregnancy, delivery mode and size of neonates in the Croatian Islands’ Birth cohort Study (CRIBS). A total of 301 mother-child dyads were included in this study. The classification of the pre-pregnancy nutritional status followed WHO BMI cut-offs. Blood samples of women were taken in the second trimester of pregnancy and analysed for fasting blood glucose level, urates, creatinine, uric acid, total protein, bilirubin, triglycerides, total cholesterol, HDL and LDL cholesterol, potassium, sodium, aspartate transaminase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), homocysteine, fibrinogen and lipoprotein A. The neonates’ length in cm and weight in gm were measured immediately after delivery at the University Hospital Split. Differences in mean values of biochemical parameters and neonates’ size between pre-pregnancy BMI categories were tested using One-way ANOVA (p < 0.05) and differences in prevalence of delivery mode using the Chi-square test. Nutritional status before pregnancy showed that 4% of women were underweight (BMI < 18.5 kg.m2), 75.1 % had normal weight (BMI 18.5–24.9 kg.m2), 14.6% were overweight (BMI 25–29.9 kg.m2) and 6.3% were obese (BMI ≥ 30.0 kg.m2). Pre-pregnancy obesity and overweight were significantly associated with elevated fasting glucose (p = 0.02), triglycerides (p = 0.01), and uric acid (p = 0.001) levels, and with decreased protective HDL cholesterol (p = 0.01) during pregnancy. Also, in comparison with normal weight and underweight women, obese pregnant women more often gave birth to heavier (p = 0.01) and longer babies (p = 0.036) and there was a strong correlation between higher pre-pregnancy BMI and delivery mode (p = 0.004). Obese women had 50% chance of giving birth by caesarean section in comparison with 20.1% in normal weight women. Our study confirmed that high maternal pre-pregnancy BMI could be a significant risk factor for both mother's health during pregnancy and different adverse birth outcomes, such as elevated risk of caesarean section delivery and child macrosomia. Therefore, women should be advised to attain normal weight before starting the pregnancy.
Knowledge of iron-containing foods among pregnant women in Lagos, Nigeria
Authors: Adeboye Temitope Elizabeth , Okekunle Akinkunmi Paul 
Published: June 2020

Abstract IntroductionAnaemia in pregnancy is a global public health problem and about half of all anaemia cases among pregnant women in developing countries are attributable to iron (Fe) deficiency. Perhaps, nutritional knowledge on the vitality of Fe-containing foods among pregnant women is lacking. In the light of the perpetually high burden of anaemia in pregnancy in Nigeria, we conducted a study to assess the knowledge of Fe-containing foods among pregnant women in Lagos, Nigeria.Materials and MethodsFour hundred and thirty two (432) pregnant women in the 2nd and 3rd trimester of pregnancy (across eight Primary Health Centers in a local government area) from Lagos Nigeria identified through multi-stage sampling method completed validated semi-structured questionnaires on socio-demographic characteristic and knowledge of Fe-containing foods using a validated 10-question knowledge scale (designed by nutrition experts) measured on a 2-point scale. Knowledge score (KS) was categories as poor (2 test was used to evaluate the association between age groups, education, marital status and knowledge of Fe-containing foods (at P < 0.05).ResultsMean age of all respondents was 28.5 ± 4.6years and 43.3% were below 28years. Mean gestational age was 31.3 ± 4.1weeks, 6.5% and 1.9% reported having a primary formal education only and never married respectively. Mean knowledge score of all respondents was 6.7 ± 2.2 and 34.7% had poor KS about Fe-containing foods. While age of respondents was insignificantly associated with KS, proportion of pregnant women who had good KS was significantly higher (χ2 = 6.6, P = 0.01) among those with at least a college education (66.8%) compared to their counterpart having at a primary formal education only (42.9%). In addition, proportion of respondents with poor KS was significantly lower (χ2 = 9.9, P = 0.007) among those ever married (34.8%) compared to respondents who never married (75.0%).ConclusionAside nutrition education, the vitality of adequate formal education for women prior to pregnancy and care giving roles cannot be undermined in advancing the knowledge of women on anemia and alleviating the burden anaemia in pregnancy in developing countries.
Explorative screening of potential peptide activities generated by plant-based proteins after in vitro simulation of static digestion
Authors: Dugardin Camille , Cudennec Benoît , Caron Juliette , Guérin-Deremaux Laetitia , Lefranc-Millot Catherine , Ravallec Rozenn 
Published: June 2020

AbstractIntroductionThe gastrointestinal digestion of food proteins can generate peptides having a wide range of biological activities and possibly involved in many physiological processes. In this study, we screened various potential bioactivities generated by plant-based protein samples as compared to one animal-based protein after in vitro simulation of gastrointestinal digestion (SGID).Materials and methods1 protein samples: Whey protein (WhP) as an animal protein reference (tested twice, in each set), 3 grades of pea protein (PeaP1, PeaP2 and PeaP3) and an hydrolyzed pea protein (HPeaP), pea and wheat albumins (PeaA and WA), wheat protein (WP), potato, fava bean and oat proteins (PP, FBP and OP) were submitted to SGID.Undigested and digested protein samples were then tested in different in vitro, cellular or acellular models, including measures on : 1/energy homeostasis through their ability to promote satiety hormones (CCK and GLP-1) secretion by STC-1 cells, to inhibit DPP-IV activity and to interact with opioid receptors; 2/anti-hypertensive properties through their ability to inhibit ACE activity; 3/anti-inflammatory properties through their ability to decrease IL-8 secretion by Caco-2 cells submitted or not to LPS; 4/antioxidant properties through their ability to inhibit production of the 3 reactive oxygen species (ROS): O2.-, H2O2 and HO..ResultsThe SGID of the 11 protein samples led to bioactive peptides able to stimulate CCK and GLP-1 secretion by enteroendocrine cells in a dose-dependent manner, to inhibit in vitro DPP-IV and ACE activity and to bind opioid receptors. They were also able to decrease production of ROS. Anyway, no anti-inflammatory impact through inhibition of IL-8 secretion has been highlighted in this study but no pro-inflammatory impact was detected neither; even more, some protein samples lost their pro-inflammatory potential after digestion. The best candidates answering globally to the main activities explored were PeaP1, PeaP2, HPeaP, PP and FBP with some specificities.DiscussionThese protein samples could thus be potentially valorized in the future in the context of type 2 diabetes and related cardiovascular risk prevention, or for their antioxidant properties in the context of cardiovascular diseases or ageing. Moreover, those peptides could offer natural preventive alternatives to some drugs. This will need further exploration and in vivo validation.
Yerba mate may prevent diabetes according to a crossover, randomized, controlled study in humans
Authors: Sarria Beatriz , Martinez-Lopez Sara , García-Cordero Joaquin , Gonzalez-Ramila Susana , Mateos Raquel , Bravo Laura 
Published: June 2020

AbstractYerba mate (Ilex paraguariensis) infusions have been shown to reduce plasma glucose in animals and serum lipids in humans. However, the effects of regularly consuming yerba mate on glucose metabolism in humans has been less studied. The objective of the study was to evaluate the effects of regularly consuming yerba mate on diabetes related biomarkers in healthy and moderately hypercholesterolemic people.A randomized, crossover, controlled study was carried out in normocholesterolemic (NC, n = 25) and hypercholesterolemic (HC, n = 27), non-smoker and non-vegetarian, men and women, with BMI 18–25 kg/m2. After a run-in stage, the effects of consuming three servings/day of yerba mate in boiled water during 8 weeks (mate stage) were compared with an isotonic drink during the same time (control stage). Along the study, polyphenol rich foods were restricted. At the beginning and the end of each intervention, urine and blood samples were collected. Dietary records and physical activity questionnaires were completed in each stage. Glucose was analyzed using a colorimetric kit (Sprinreact), and insulin, glucagon, C-peptide, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), plasminogen activator inhibitor-1 (PAI-1), resistin and visfatin were analyzed using Bio-Rad Multiplex Diabetes kits on Bio-Plex MAGPIX system. Results were statistically studied using a mix model with repeated measures and a Bonferroni test within each group (SPSS 23.0).Nutrient intake and physical activitiy did not show changes along the study. In contrast, fasting levels of glucose, insulin, glucagon, and GLP-1 significantly decreased after the mate stage, showing glucagon a significant yerba mate*group interaction. Attending to these results, it may be concluded that sustained consumption of yerba mate may prevent type 2 diabetes. These outcomes indicate that the effects of yerba mate in pre-diabetes and T2DM subjects are worth further studying.Funded by the Spanish State Research Agency, projects AGL2010-18269 and AGL2015-69986-R
Adipose tissue fatty acid and lipid mediator composition in obesity and response to chronic marine omega-3 fatty acid supplementation
Authors: Fisk Helena , Ayres Rob , Childs Caroline , Miles Elizabeth , Kudak Ondrej , Kopecky Jan , Calder Philip 
Published: June 2020

AbstractIntroduction:Obesity is an excess of adipose tissue (AT) and is linked with increased inflammation that enhances risk of type-2 diabetes and cardiovascular disease. The BIOCLAIMS study assessed the fatty acid (FA) and lipid mediator composition in normal weight and obese individuals, and their response to chronic omega-3 FA supplementation.Materials and methods:AT biopsies were collected pre- and post-12 week supplementation with 1.1 g EPA + 0.8 g DHA/day or corn oil. The composition of FA in the total lipid extract (TLE) of AT from 37 normal weight and 44 obese subjects was assessed by gas chromatography (GC) and the concentration of lipid mediators in AT TLE of 36 normal weight and 45 obese subjects by coupled GC-mass spectrometry.Results:AT of obese subjects had higher concentrations of arachidonic acid (AA), EPA, DPA, PGF2α, arachidonoylethanolamine (AEA), and eicosapentaenoylethanolamine (EPEA) than that of normal weight subjects (P < 0.05). Obese subjects also had and lower concentrations of mediators derived from linoleic and α-linolenic acids, DHA-derived mediators including RvD2 and hydroxydocosahexaenoic acids (HDHAs), AA-derived mediators including lipoxin-B4, hepoxilin-A3, 11,12-dihydroxyeicosatetrienoic acid (DHET), and 6-keto-PGF1α, and the FA ethanolamine of myristic acid and glycerol ester of palmitic acid (P < 0.05 all) than normal weight subjects.Chronic supplementation with EPA + DHA increased the concentration of EPA (P = 0.006) and EPA-derived lipid mediators including dihydroxyeicosatetrienoic acids, EPEA, and EPA-glycerol ester (P < 0.05), and increased the concentration of DHA (P < 0.001), docosahexaenoylethanolamine, and 8-, 11-, 14-, and 16-HDHA (P < 0.05). Chronic supplementation with EPA + DHA also decreased the concentration 4-, 17-, and 20-HDHA, and AA-derived lipid mediators including DHETs, AEA, and LTs in normal weight subjects (P < 0.05), and decreased 2-AG in obese subjects (P < 0.05).Discussion:These data indicate altered lipid signalling in AT in obesity (at baseline) suggesting dysregulation of adipose tissue expansion and inflammatory signalling, including lack of self-resolution, as well as dysregulation in the utilization of supplementary EPA + DHA for synthesis of anti-inflammatory lipid mediators. EPA + DHA are able to modulate synthesis of EPA-, DHA- and AA-derived lipid mediators but obesity may involve resistance to these effects particularly in endocannabinoid synthesis.
Serum levels of 25 (OH) vitamin D in adults with obesity sarcopenia
Authors: Nikolova Maria , Penkov Alexander 
Published: June 2020

AbstractIntroduction:Obesity has been linked with vitamin D deficiency in a number of cross-sectional studies, reviews and meta-analyses. To assess the correlations of plasma 25(OH) vitamin D levels with indices of body composition examined by DXA with an emphasis on lean and bone mass as well as on indices such as android/gynoid fat, appendicular lean mass (ALM) and appendicular lean mass index (ALMI), fat-mass indexes (FMI), fat-free mass indexes (FFMI) and the ALM-to-BMI index.Materials and Methods:62 adult subjects consented to participate – 27 men (43.5 %) and 35 women (56.5 %). Their mean age was 45.3 ± 9.5 years. Fan-beam dual-energy X-ray (DXA) body composition analysis was performed on a Lunar Prodigy Pro bone densitometer with software version 12.30. Vitamin D was measured by electro-hemi-luminescent detection as 25(OH)D Total (ECLIA, Elecsys 2010 analyzer, Roche Diagnostics). Statistical analyses were done using the SPSS 23.0 statistical package.Results:The serum 25(OH)D level was correlated significantly only to the whole body bone mineral content, the appendicular lean mass index (ALMI) and the ALM-to-BMI index, underlining a predominant role for lean and fat-free mass. Vitamin D showed a very weak correlation to % Body Fat and the Fat Mass Index (FMI) in men only. Moreover, the multiple regression equation including the associated parameters could explain only 7 % of the variation in the serum 25(OH)D levels.Discussion:Our conclusion was, that there are differences in the associations of the vitamin D levels with the different body composition indices, but these associations are generally very weak and therefore – negligible.