bluuebunny/crossref_metadata_2025_split huggingface dataset:
COSMIC FEASIBILITY STUDY: COMPARING OPEN SCARF OSTEOTOMY AND MINIMALLY INVASIVE CHEVRON OSTEOTOMY FOR HALLUX VALGUS CORRECTION
Authors: Kakwani Mehak , Pujol-Nicolas A , Griffiths A , Hutt N , Townshend D , Murty A , Kakwani R 
Published: December 2024

ObjectivesMinimally invasive surgery (MIS) has gained popularity for hallux valgus, compared to the traditional scarf osteotomy (OS). Though evidence suggests similar clinical outcomes, there is paucity of randomised controlled studies. This study aimed to assess the feasibility of conducting a randomised controlled trial comparing the patient recorded and clinical outcomes for the surgical management of Hallux Valgus between OS and MIS Chevron Akin (MICA).MethodsPatients suitable for surgical correction were invited to participate. Post-op rehabilitation was standardised for both groups. Patients completed a validated questionnaire (Manchester Oxford Foot questionnaire and EQ-5D-5L) pre-operatively and post-operatively at 6 months and 1 year. Radiological parameters and range of motion were measured pre-and post-operatively.Results31 patients were recruited between Dec 2017 and June 2022. 17 patients were randomised to MICA (15 female, mean age 51) and 15 to OS (14 female, mean age 51). Both groups had a significant improvement in all MOXFQ parameters at 6m and 12m, as well as radiological parameters. VAS improved for OS (p=0.048) and for MICA (p=0.059) at 6m.There was no significant improvement in EQ-5D in either group at 12 months and no significant difference in operative time (p=0.53). There was a higher number of complications in the MICA group with 5 removal of metalwork (29.4%) and 2 superficial infections (11.8%) versus none in the OS group. The dorsiflexion significantly improved in the OS group at 6months (p=0.04). Recruitment rate dipped during COVID. No patients were lost at follow up.ConclusionBoth surgical options show similar clinical results, but higher complication rates were seen with MICA. This study illustrates the feasibility to conduct a randomised control trial for the comparison between the two techniques.Challenges to recruitment included surgeon equipoise, patient preference, training requirement and the pandemic which could be mitigated in a larger study.
FUNCTIONAL OUTCOMES OF ELBOW HEMIARTHROPLASTY FOR DISTAL HUMERUS: A VIABLE OPTION IN COMPLEX DISTAL HUMERUS FRACTURES
Authors: Rai Avinash , Nanda Rajesh , Ponugoti Nikhil , Saunders Mark 
Published: December 2024

ObjectivesDistal humerus fractures in elderly population are often comminuted and presents multiple challenges. When managed with fixation the results are often complicated with stiffness, pain, and reduced function while total elbow replacement is fraught with lifelong restrictions on load bearing which can significantly affect elderly patients who rely assistive devices for ambulation. Elbow hemiarthroplasty however, presents a viable alternative in these cases. This series evaluates the results of the distal humerus hemiarthroplasty in a single centre.Designs and methodsData was collected retrospectively. Comprehensive case reviews were done to collect demographic, intra-operative and post-operative data. Fractures were classified as per AO classification. The primary outcome was functional outcome and range of motion (ROM). The secondary outcomes were complications and patient satisfaction.Results22 cases were included in this study from 2016 – 2023 majority being females (n=18). Mean age was 74years (SD −11.2). Majority fractures were AO type C3 (n=15) with two A2 type fractures managed for non-union. Pre-existing bone on bone arthritis was present in 3 cases and CT scan was done for 12 patients to assess fracture configuration. Excluding those treated for non- union the median time between fracture and surgery was 8.5 days. Follow-up of more than 6 months was available for 16 patients with median follow-up of 18 months. ROM was available for 17 patients with 13 (50%) patients having functional ROM. No patients had full extension and there was a mean lag of 200. Mean flexion was 118.20. Nearly 2/3rd patients (73%- n=16) were satisfied with the surgery with no problems in activity of daily living. Complications seen were ulnar neuropathy (n=3), heterotopic ossification(n=2) and periprosthetic fracture (n=1).ConclusionThis single centre study suggests good outcomes following distal humerus hemiarthroplasty. It is a reasonable alternative to fixation and total elbow arthroplasty in complex fractures.
Diabetes distress, the mediator of the poor glycemic control and depression: A meta-analysis
Authors: Mirghani Hyder O 
Published: December 2024

BACKGROUND
Diabetes-related distress (DRD) is a common psychological disorder specifically associated with diabetes, its cross-talk with depression, and glycated hemoglobin (HbA1c) was discussed controversially. Interventions addressing DRD were shown to improve HbA1c. However, the primary concern is to investigate the association of DRD with glycemic control. No meta-analyses have compared the effects of depression and diabetes distress on HbA1c.
AIM
To assess the relationship between DRD, depression, and glycemic control.
METHODS
We systematically searched PubMed MEDLINE, Google Scholar, and Cochrane Library from inception up to May 2024. The keywords diabetes distress, depression, psychopathology, glycemic control, HbA1c, glycated hemoglobin, fasting, and postprandial blood glucose were used. A datasheet was used to extract the author’s name year and country of publication, diabetes distress, depression, and HbA1c among patients with DRD, depression, and control subjects.
RESULTS
Out of the 2046 studies retrieved, 55 full texts were screened and 22 studies were included in the final meta-analysis. Diabetes distress was associated with poor glycemic control, odd ratio = 0.42, 95% confidence interval (CI): 0.17-0.67, and P value < 0.001, and odd ratio = 0.52, 95%CI: 0.38-0.72, and P value < 0.001 respectively. No significant difference was observed between depression and DRD regarding the impact on HbA1c, odd ratio = 0.13, 95%CI: 0.15-0.41, P value = 0.37, I 2 for heterogeneity = 76%. However, when heterogeneity was eliminated, diabetes distress influenced the HbA1c more compared to depression, odd ratio = 0.29, 95%CI: 0.17-0.41, and P value < 0.001.
CONCLUSION
DRD negatively influenced the HbA1c and glycemic control more than depression. Further studies using more specific measures (ecological momentary assessment) to assess DRD are recommended.
The unmet needs of adopting clinical decision support system among physicians in Palestinian hospitals
Authors: Sultan Haya , Najjar Shahenaz , Awartani Faisal , Abu-Odah Hammoda 
Published: December 2024

Introduction
Clinical decision support system (CDSS) is an application used to aid decision-making and provide knowledge regarding treatment, diagnosis, and laboratory testing. Despite the associated benefits, the underutilization of CDSS is causing a global challenge. In Palestine, CDSS remains unimplemented, prompting a study on knowledge levels and factors influencing CDSS acceptance among physicians.

Objective
The study aimed to assess physicians’ knowledge of CDSS and understand factors impacting CDSS adoption, including performance expectancy (PE), effort expectancy (EE), computer self-efficacy, involvement in decision-making, perceived threat to autonomy, and social influence.

Methods
A validated questionnaire-based survey consisting of seven constructs was used in this study. The constructs were derived from the unified theory of acceptance and use of technology (UTAUT). The target population was 363 resident physicians and general practitioners (GPs) from three governmental hospitals. In total, 124 participants were enrolled, and data was collected between June 1 and June 30, 2022. Generalized linear regression was used for data analysis.

Results
Most participants were males (75%), with an average of 2.9 years of experience. Despite limited CDSS knowledge, participants strongly intended to adopt it (mean = 3.91, SD = 0.65). Our results showed a significant effect of PE (p = 0.000, r = 0.469), EE (p = 0.001, r = 0.294), computer self-efficacy level (p = 0.015, r = 0.218), perceived threat to professional autonomy (p = 0.001, r = -0.302), and social influence (p = 0.047, r = 0.179) on the intention to adopt CDSS. However, involvement in decision-making about CDSS had no significant impact (p = 0.123, r = 0.140).

Conclusion
This study provides the basis for implementing CDSS in Palestinian settings. Despite the readiness of Palestinian healthcare providers, introducing CDSS as an aiding, effort-free tool is a prerequisite for successful CDSS adoption in Palestine.
Coping strategies employed by older Nepalese migrant women to manage their mental distress in the UK: A qualitative research
Authors: Sah Lalita Kumari , Sah Rajeeb Kumar , Singh Devendra Raj , Burgess Rochelle A. 
Published: December 2024

Introduction
Mental health and wellbeing is a global public health concern. However, there is limited evidence on managing the mental health needs of the Nepalese migrant population in the UK. This paper is focused on exploring coping strategies employed by older Nepalese migrant women in managing their mental distress.

Methods
A qualitative study informed by a narrative approach was conducted among twenty Nepalese older women living in London. Interviews were analysed using thematic analysis.

Results
Findings identified three major coping strategies used by Nepalese older women: i) Engaging others to access human, social and economic resources in problem focussed strategies; ii) Using emotion-focussed strategies through drawing on human and social resources; and iii) Employing emotion-focussed strategies through prayer and acceptance. Each strategy reflected the strategic use of existing resources, highlighting a strong sense of ownership over their mental wellbeing.

Conclusion
Nepalese women used both problem-focused and emotion-focused coping strategies to manage their mental distress while living in the UK. However, they had poor awareness of the availability or potential benefits of mental health services in managing their distress and were not able to identify their everyday survival as strengths. We assert social interventions that build on women’s abilities are essential to promote mental health and wellbeing.
Dynamics of submicroscopic and microscopic asymptomatic malaria infection and associated factors: A longitudinal study in South Benin
Authors: Telfils Rodeline , Dossou Akpéyédjé Yannelle , Djènontin Armel , Adimi Elisée , Akoho Romuald , Bailly Justine , Bouraïma Aziz , Matondo Déborah , Sissinto-Savi de Tove Yolande , Houinato Dismand , Massougbodji Achille , Dechavanne Célia , Cottrell Gilles 
Published: December 2024

Introduction
Asymptomatic malaria infection is now recognized as a potential threat to malaria control. However, its prevalence and its dynamics are poorly documented especially in a perennial context of high seasonal transmission. A longitudinal study was conducted in southern Benin to investigate the dynamics of asymptomatic malaria infection and to identify factors influencing it.

Methods
A cohort of 377 participants was recruited, stratified into three age groups (under 5 years, between 5 and 15 years, over 15 years). After inclusion, two visits were made one-month apart between August and November 2021. Malaria infection was diagnosed by microscopy and PCR and questionnaires were administered to the participants. The dynamics of malaria infection, both submicroscopic (positive PCR / negative blood smear) and microscopic (positive blood smear), and related factors were determined using a mixed ordinal polytomous regression model and a multistate Markov model.

Results
The human infectious reservoir consisted primarily of asymptomatic submicroscopic infections (289/512 (56.4%)), followed by asymptomatic microscopic infections (182/512 (35.5%)) and symptomatic infections (41/512 (8%)). The prevalence of asymptomatic infection was highly related to age-group (5–15 years: OR: 4 .12 [2.55–6.67] and > 15 years OR: 2.80 [1.73–4.54] compared to the under 5 years old group). The children under 15 years with asymptomatic infection had the highest risk of becoming symptomatic. The mean duration of asymptomatic infections in 5–15-year-olds was the longest (76.7 days (53.8–109.1)).

Conclusion
This study revealed a persistent asymptomatic malaria reservoir over the follow-up period, with substantial variations between age-groups. These findings are important elements to consider for an optimal deployment of malaria control interventions.
Knowledge generation towards evidence-based practice and nursing competency
Authors: Konlan Kennedy Diema , Adedia David , Nyande Felix K. , Amenuke Margaret , Tackie Vivian , Anaman-Torgbor Judith A. 
Published: December 2024

Aim
This study aims to describe the nursing competency, research knowledge and skills of nurses in Ghana regarding evidence-based practice.

Methods
This nationwide descriptive cross-sectional survey was conducted among 480 clinical nurses and nurse educators from both private and public institutions. Nurses were included in the study if they had a full-time or part-time appointment, were in active service, and had a valid Personal Identification Number from the Nursing and Midwifery Council of Ghana. The Mann-Whitney U-test was used to compare mean rank scores between two groups, and the Kruskal Wallis H-test was used for the comparison.

Results
Thirty percent of them rated their ability to formulate research questions, conduct literature search and retrieval, and critical analysis of scientific literature as fair or poor. Half of the nurses disagreed with changing to new methods, and more than half at least agreed with all the items measuring the use of evidence-based practice. One out of every 20 Nurses somewhat disagreed with formulating answerable research questions at work, and the same proportion disagreed or were neutral to integrating evidence into practice with their expertise. It was statistically significant that females (p-value = 0.001), married (p-value = 0.054), Christians (p-value<0.001), nurse educators (p-value<0.001) and part-time workers (p-value<0.001) were more likely to have higher mean scores on research knowledge and skills. The Kruskal Wallis test showed that research knowledge and skills (H = 97.281, p-value<0.001, df = 2), attitude towards evidence-based practice (H = 10.143, p-value = 0.006, df = 2), and nursing competencies (H = 9.041, p-value = 0.011, df = 2) differ for all the educational level of all nurses.

Conclusion
The self-reported competencies in the various aspects of the research process and knowledge generation by both clinicians and nurse educators were good; however, the overall composite score revealed that nurses only had fair knowledge and skills in this regard. Nurses should be given the requisite training to appraise and evaluate nursing research for incorporation into nursing practice.
Association between Angiotensin-converting enzyme (ACE) insertion/deletion polymorphism and hypertension in a Ghanaian population
Authors: Bonney Precious , Obirikorang Christian , Quaye Lawrence , Dapare Peter Paul , Adams Yussif , Bourawono Grace , Akaluti Mercy , Duodu Jemimah 
Published: December 2024

Background
Genetic modifications in the renin-angiotensin aldosterone system (RAAS) have been suggested to play a key role in the pathophysiology of hypertension. The insertion/deletion polymorphism of angiotensin-converting enzyme (ACE) gene phenomenon and its relationship with essential hypertension has not been explored within the Ghanaian population. This study aims to determine the relationship between the ACE I/D polymorphism and the risk of essential hypertension among patients seeking medical attention.

Methods
This case-control study was conducted at the Tamale Central Hospital in Ghana. A total of 144 study participants comprising 72 hypertensive patients and 72 normotensive individuals were recruited from May to July 2022. The modified WHO step questionnaire for chronic diseases was used to collect ACE concentrations and electrolytes were estimated and molecular testing conducted using to identify genotypes. To compare continuous variables between two groups and among multiple groups, the Student’s t-test and analysis of variance (ANOVA) were used respectively. Genotype and allele frequencies were determined through direct counts, while differences in the distribution of alleles and genotypes between groups were estimated using chi-squared test.

Results
The distribution of DD genotype and D allele respectively was 26.4% and 54% in hypertensives and 50% and 72% in normotensives. DD genotype significantly increased the risk of hypertension after adjusting for age and BMI (aOR = 8.52, 95% C.I = 1.22–59.6). In the recessive model, the risk of hypertension increased four times in subjects with the DD genotype (aOR = 4.09, 95% CI = 1.28–13.05). ACE levels were significantly elevated among hypertensives compared to controls, but did not significantly differ between the DD genotype and II+ID genotypes among hypertensives and normotensive subjects.

Conclusion
The study shows that the presence of the DD genotype is strongly associated with an increased risk of hypertension in the Ghanaian population.
Lebanese cannabis oil extract protected against folic acid-induced kidney fibrosis in rats
Authors: Bylan Diana , Khalil Alia , Shebaby Wassim , Habchy Christabel , Nasser Selim , Faour Wissam H. , Mroueh Mohamad 
Published: December 2024

Background
Renal fibrosis is a major manifestation of chronic kidney disease. To date, there are no treatments to reverse kidney fibrosis. Cannabis is an aromatic herb that is widely known for its anti-diabetic and anti-inflammatory properties. The aim of this study is to evaluate the protective effect of Lebanese cannabis oil extract (COE) against folic acid (FA) induced renal injury both in vitro and in vivo.

Materials and methods
A single dose of 250 mg/kg of Folic acid was administered to induce renal fibrosis in rats. COE was injected at varying doses of 5, 10, and 20 mg/kg. Body weight of rats were monitored and clinical parameters including serum creatinine, urea, and electrolytes were measured. Moreover, pathological examination of the kidney and heart was performed. Conditionally immortalized cultured rat podocytes were exposed to high concentrations of folic acid in the presence or absence of COE. MTS and in vitro scratch assay were used to assess podocyte cells viability and migration respectively. Western blot analysis was used to evaluate the phosphorylation levels of AKT and p38 MAPK.

Results
Rats that received FA showed a marked increase in serum creatinine when compared to the non-treated control group. COE at doses of 5 and 10 mg/kg significantly decreased serum creatinine induced by FA. Serum sodium was significantly reduced in all the groups receiving COE. Furthermore, COE ameliorated renal and cardiac pathology abnormalities caused by FA in a dose-dependent manner. Cell viability assay revealed that COE reversed cytotoxicity induced by FA in rat podocytes. In vitro scratch assay showed that COE partially restored the migratory capacity of podocytes incubated with FA. Dose-dependent experiments showed that COE (1 and 2μg/ml) induced a significant increase of phospho-(S473)-AKT along with a decrease in phospho (T180 + Y182) P38 levels.

Conclusion
The current results revealed important protective effect of Lebanese cannabis oil extract against folic acid—induced renal fibrosis in rats.
Materials libraries as knowledge tools on the path toward a circular construction industry
Authors: Seebacher Andreas , Böhm Sandra , Boerman Elena 
Published: December 2024

Extensive factual and target knowledge about the need for a turnaround in the construction industry and a circular building sector must be effectively communicated to stakeholders and translated into practical knowledge. Materials libraries that are geared toward circularity and embedded in supra-regional networks have the potential to positively influence teaching, science, and practice: through the direct haptic experience of a real sample collection of building materials and associated research-based information databases in digital, location-independent form.
Analysis of Greenhouse Gas Emission Load and Emission Reduction from Switching to Electric Vehicles: A Case Study of Java Island
Authors: Wicaksono Surya Adi , Huboyo Haryono Setiyo , Samadikun Budi Prasetyo , Joyosemito Ibnu Susanto 
Published: December 2024

In order to mitigate the impact of climate change arising from Greenhouse Gas (GHG) emissions generated from the transportation sector, many countries including Indonesia, have initiated to develop policies to encourage environmentally friendly transportation technologies. Electric vehicles represent a highly sustainable alternative when compared to conventional vehicles. This study aims to assess the potential reduction of GHG emissions from the shifting to electric vehicle utilization on Java Island. The research method was conducted by modeling conventional vehicles until 2033 where there was a transition to electric vehicles throughout the model year and then calculating the GHG emission. This study employs three scenarios : Business As Usual (BAU), Electric Vehicle Plan (EVP) with existing scenario power plant and Electric Vehicle Plan (EVP) with National Energy Plan (NEP) scenario power plant. Model results revealed potential GHG emission reductions within 12.11% from the Existing EVP scenario and 12.54% from the NEP scenario against the BAU scenario due to the shifting usege of electric vehicles on Java island. Based on the model results, it is possible to determine that shifting from conventional vehicles to electric vehicles can reduce GHG emissions from conventional vehicle use.
Analysis of the Water Quality of the River in West Java as the Raw Water for Drinking Water
Authors: Djembarmanah Rachmawati Sugihhartati , Salsabila Gina 
Published: December 2024

The quantity of raw water from springs, groundwaters, and rainwaters has been decreasing nowadays. This has mostly made river water to be used as the raw water to be treated for drinking water by PDAMs. However, in 2020, 52 rivers in Indonesia were polluted. Therefore, it is necessary to analyze the quality of the river water to ensure that the water conforms with the standards of the Indonesian Government Regulation Number 22 of 2021 (class 1). This study was done to study the water quality i.e. DO, TSS, and total coliform in 9 sampling points in Citarum, Cimanggu, Cibogo, Citonjong, Ciwayang, and Cigugur Rivers in West Java. Grab samples were collected and were analyzed in the laboratory. The results were then compared with the standards. DO in the Citarum River (= 3.66 mg/L) and Cimanggu River (= 3.64 mg/L) samples were below the standard which might result from the domestic waste generated by the housing settlements, schools, and hospital existed around the sampling points. Total coliform in the upstream of the Cibogo River sample was above the standard; which could be caused by the domestic waste produced by the housing settlements and the fishing area located around the sampling point.
Colombeau algebras of asymptotically almost automorphic generalized functions: Properties and applications
Authors: Chaib Mohamed , Taqbibt Abdellah , Melliani Said , El Omari M’hamed 
Published: December 2024

Abstract
In this manuscript, we introduce a new class of Colombeau algebras based on asymptotic almost automorphic functions and we prove some important properties of asymptotic almost automorphic generalized functions.
We also illustrate all this in examples as an application.