bluuebunny/crossref_metadata_2025_split huggingface dataset:
The genetics of aortopathies: Hereditary thoracic aortic aneurysms and dissections
Authors: Chou Elizabeth L. , Lindsay Mark E. 
Published: February 2020

AbstractAortopathies encompass a variety of inherited and acquired pathologies that increase risk of life‐threatening dissection or rupture. Identifying individuals with hereditary thoracic aortic aneurysm and dissection (HTAAD) for longitudinal monitoring, medical therapy, or elective and preventative repair is paramount to reduce risk of cardiovascular‐related mortality and complications from dissection and rupture. Over the past couple of decades, pathogenic variants in numerous genes have been identified in relation to HTAAD. The genetic diagnosis can help stratify patient risk and provide guidance on medical treatment, timing of prophylactic surgical repair, as well as longitudinal surveillance and imaging. Implicated genes and their associated proteins have been found to act on a diverse variety of pathways, cells and structural components linked to transforming growth factor beta (TGF‐β) signaling pathways, disruption of the vascular smooth muscle cell contractile apparatus, and primary disruption of extracellular matrix homeostasis. This review describes relevant genetic variants that may help identify and guide the management of hereditary thoracic aortic aneurysms and dissections.
Process systems engineering applications, challenges and opportunities in the toll manufacturing industry
Authors: Arora Akhil , Hasan M. M. Faruque 
Published: February 2020

AbstractThere is a drive in chemical industries toward outsourcing many operations so that companies can effectively focus on their core competencies, and can rapidly acquire processing capabilities without setting up new facilities. This concept of toll manufacturing is based on a sharing‐economy model for on‐demand chemical production services. In toll manufacturing, the customer or consumer company provides raw materials to a toll manufacturer who then offers the rest of processing services. Due to distributed chemical production supply chains and decentralized nature of tolling model, a new set of challenges arise for both consumers and manufacturers. This article presents the prevalent applications of toll manufacturing in chemical industries, identifies key challenges of the sharing‐economy model, and highlights the opportunities and key issues of using process systems engineering (PSE) approaches to help toll manufacturing.
Keteniminium‐Driven Umpolung Difunctionalization of Ynamides
Authors: Dutta Shubham , Yang Shengwen , Vanjari Rajeshwer , Mallick Rajendra K. , Gandon Vincent , Sahoo Akhila K. 
Published: February 2020

AbstractA three‐component Pd‐catalyzed coupling of ynamides, aryl diazonium salts, and aryl boronic acids for the synthesis of novel triaryl‐substituted enamides is described. This transformation represents the first example of an umpolung regioselective unsymmetrical syn‐1,2‐diarylation/aryl‐olefination of ynamides. The aryl moieties of the diazonium salt (electrophile) and boronic acid (nucleophile) are explicitly incorporated in the electrophilic α‐ and nucleophilic β‐position, respectively, of the ynamide, resulting in a single isomer of the N‐bearing tetrasubstituted olefin. The scope is broad (68 examples), showing excellent functional‐group tolerance. DFT calculations substantiate the rationale of the mechanistic cycle and the regioselectivity. The chemoselectivity and synthetic potential of the enamide products were also studied.
Non‐destructive research in the surroundings of the Roman Fort Tibiscum (today Romania)
Authors: Pisz Michał , Tomas Agnieszka , Hegyi Alexandru 
Published: February 2020

AbstractThe Roman military fort Tibiscum which existed from the beginning of the second up to the third quarter of the third century ad was manned by various auxiliary units, including Syrian Palmyrenians and Germanic Vindelici. Its irregular shape and relatively big surface, usual for the forts of that type, as well as not having entirely clear settlement structures visible on both sides of the Timiş River drew attention of many scholars. The non‐destructive research project carried out in 2014–2016 allowed to reassess the ancient landscape around the fort. Although the site was excavated for almost 100 years, the rural hinterland of Tibiscum has never been investigated systematically. An integrated archaeological prospection method combined with the use of modern surveying tools resulted in establishing the accurate position of the known extramural remains and the location of a dozen of new sites and features within the radius of ca 3 km around the fort. The results of the surveys compared with the old maps and previous excavations led to the new conclusions concerning the topography of Roman Tibiscum and the development of the civilian settlement in its vicinity. The analysis of acquired archaeological data compared with historical sources give assumptions to the question of the existence of a separate town on the east side of the Timiş River which was granted municipal status by the end of the second century ad. The authors of the present article are rather willing to believe that it was the extramural settlement (vicus), located on the west bank of Timiş, which was granted municipal rights, probably at the end of the second or at the beginning of the third century ad.
The impact of varying seasonal lengths of the rainy seasons of India on its teleconnections with tropical sea surface temperatures
Authors: Misra Vasubandhu , Bhardwaj Amit 
Published: February 2020

AbstractWe present in this paper the interannual variability of seasonal temperature and rainfall in the Indian meteorological subdivisions (IMS) for boreal winter and summer seasons that take in to account the varying length of the seasons. Our study reveals that accounting for the variations in the length of the seasons produces stronger teleconnections between the seasonal anomalies of surface temperature and rainfall over India with corresponding sea surface temperature anomalies of the tropical Oceans (especially over the northern Indian and the equatorial Pacific Oceans) compared to the same teleconnections from fixed length seasons over the IMS. It should be noted that the IMS show significant spatial heterogeneity in these teleconnections.
Increasing clarity for an early invasive strategy in NSTEMI
Authors: Vetrovec George W. 
Published: February 2020

Key Points
An early invasive strategy for NSTEMI resulted in lower MACE and recurrent ischemia compared with a delayed strategy.
The significant risk of NSTEMI is affirmed, which warrants earlier and more directed invasive treatment.
Future investigations need to confirm these findings in a randomized trial in high‐risk patients.
Long‐term effect of remote ischemic conditioning on infarct size and clinical outcomes in patients with anterior ST‐elevation myocardial infarction
Authors: Verouhis Dinos , Sörensson Peder , Gourine Andrey , Henareh Loghman , Persson Jonas , Saleh Nawzad , Settergren Magnus , Sundqvist Martin , Tengbom John , Tornvall Per , Witt Nils , Böhm Felix , Pernow John 
Published: February 2020

AbstractBackgroundConflicting evidence exists concerning the cardioprotective efficacy of remote ischemic conditioning as an adjunct to primary percutaneous intervention (PCI) in ST‐elevation myocardial infarction (STEMI) and data on long‐term outcomes are scarce. We evaluated final infarct size by cardiac magnetic resonance (CMR) performed 6 months after anterior STEMI treated with remote ischemic conditioning and clinical outcomes up to 3 years after the event.MethodsOne hundred and fifteen patients with anterior STEMI were randomized to remote ischemic per‐postconditioning (RIperpostC) or sham procedure as adjunct to primary PCI. The primary outcome was myocardial salvage index (MSI) on CMR 6 months after the event. Secondary outcomes were absolute infarct size, left ventricular function, cardiac mortality, major adverse cardiac and cerebrovascular events (MACCE—composite of all‐cause mortality, myocardial infarction, readmission for heart failure, ischemic stroke, and target lesion revascularization) and all the individual components of MACCE.ResultsThere was no difference in MSI or left ventricular function between the RIperpostC and the control group after 6 months. Nor did clinical outcomes at 6 months or 3 years differ between the groups.ConclusionsRIperpostC as an adjunct to PCI in anterior STEMI did not result in better MSI or left ventricular function 6 months after the event. Furthermore, clinical outcomes at 6 months and 3 years were not altered.
Distal arteriovenous fistula formation after percutaneous coronary intervention: An old complication of a new access site
Authors: Shah Syed Raza , Kiemeneij Ferdinand , Khuddus Matheen A. 
Published: February 2020

AbstractDorsal or distal transradial artery access has recently gained popularity due to several perceived benefits that include favorable ergonomics, the potential for rapid hemostasis and lower rates of vascular complications. Still, no vascular access site is free of complications and reports of hematoma and pseudoaneurysm formation related to distal radial artery access have been reported in the literature. We present a case of a 71‐year‐old male who developed an arteriovenous fistula (AVF) involving the distal left radial artery following repeated access of the artery. This rare complication is likely avoidable with a comprehensive understanding of the surrounding anatomy and proper procedural technique, including the routine use of ultrasound for access.
Development of wall material for the microencapsulation of natural vanilla extract by spray drying
Authors: Ocampo‐Salinas Israel Oswaldo , Gómez‐Aldapa Carlos Alberto , Castro‐Rosas Javier , Vargas‐León Enaim Aída , Guzmán‐Ortiz Fabiola Araceli , Calcáneo‐Martínez Netzahualcoyol , Falfán‐Cortés Reyna Nallely 
Published: February 2020

AbstractBackground and objectivesThe aim of this study was to develop a wall material using rice starch (Oryza sativa) to optimize the microencapsulation of vanilla extract by spray drying. Native starch rice was hydrolyzed, succinated, extruded, and characterized.FindingsThe peak viscosity of modified starches was reduced from 3,875 cP to <100 cP by effect of the modification step. Native starch was gelatinized by extrusion according to gelatinization enthalpy (∆H J/g). Natural vanilla extract was encapsulated, and the most optimal conditions for the drying process were air inlet temperature of 125°C, 14.0% of total solids, and 86.2% of encapsulation efficiency. The scanning electron microscopy evidenced the formation of microcapsules; however, the confocal laser scanning microscopy showed no interaction between the wall material and the vanilla extract. This could be related to the zeta potential values of the vanilla extract and the wall material.ConclusionsModified rice starch is a potential wall material for the encapsulation of different bioactive compounds in the food sector.Significance and noveltyChemical and physical modifications such as hydrolysis, succinylation, and extrusion in native rice starch offer adequate properties to achieve 86.2% encapsulation efficiency of natural vanilla extract using spray drying.
Breast cancer suspected to originate from familial hereditary tumors: A case report
Authors: Yamamoto Shinya , Chishima Takashi , Sugae Sadatoshi , Shibata Yukako , Yamada Akimitsu 
Published: February 2020

AbstractIf familial hereditary tumor is suspected, diagnosis and treatment should always be performed considering the presence of familial hereditary tumors irrespective of whether genetic testing is performed.
Heterogeneous Olefin Hydrogenation Enabled by a Highly‐Reduced Nickel(−II) Catalyst Precursor
Authors: Maier Thomas M. , Sandl Sebastian , Melzl Peter , Zweck Josef , Jacobi von Wangelin Axel , Wolf Robert 
Published: February 2020

AbstractThe hydrogenation of olefins, styrenes, enoates, imines, and sterically hindered tri‐substituted olefins was accomplished using the pre‐catalyst dilithiumbis(cycloocta‐1,5‐diene)nickelate(−II) (1). The mild conditions tolerate hydroxyl, halide, ester, and lactone functionalities. Mechanistic studies, including reaction progress analyses, poisoning experiments, and multinuclear NMR monitoring, indicate that a heterotopic (nickel nanoparticle) catalyst is in operation.
Synthesis of an Interrupted AST‐Type Zeolitic Imidazolate Framework
Authors: Sun Yayong , Zhuo Chao , Wang Fei , Zhang Jian 
Published: February 2020

Summary of main observation and conclusionPresented here is a new interrupted AST‐type zeolitic imidazolate framework, Zn5(OH)(dmbim)9(H2O)• 4(DMF) (1) with cub and interrupted ast cages, which exhibits permanent porosity, high hydrophobicity and strong solid‐state photoluminescent properties. More importantly, structural ordered DMF molecules are firmly confined in the ‐ast cage by strong host‐guest interactions.
Efficacy and safety of radiofrequency ablation for hypertrophic obstructive cardiomyopathy: A systematic review and meta‐analysis
Authors: Yang Haonan , Yang Yuan , Xue Yuzhou , Luo Suxin 
Published: February 2020

AbstractBackgroundAlthough radiofrequency ablation is widely used in the treatment of arrhythmias, its role in septal reduction therapy of hypertrophic obstructive cardiomyopathy (HOCM) is unclear. This meta‐analysis aimed to assess the efficacy and safety of radiofrequency septal ablation for HOCM.HypothesisRadiofrequency septal ablation is effective and safe for relieving obstruction and improving exercise capacity in patients with HOCM.MethodsA systematic review of eligible studies that reported outcomes of patients with HOCM who underwent radiofrequency septal ablation was performed using PubMed, Embase, Cochrane, ProQuest, Scopus, ScienceDirect, and Web of Science database. Pooled estimates were calculated using random‐effects meta‐analysis. Methodological quality was assessed using the Newcastle‐Ottawa scale. Publication bias and sensitivity analyses were also performed.ResultsEight studies with 91 patients (mean follow‐up 11.6 months) were included. The left ventricular outflow tract (LVOT) gradient at rest decreased significantly after radiofrequency septal ablation (pooled reduction: −58.8 mmHg; 95% confidence interval [CI] −64.3 to −53.5). A reduction was also found in the provoked LVOT gradient with a pooled reduction of −97.6 mmHg (95% CI: −124.4 to −87.1). An improvement of the New York Heart Association classification (mean: −1.4; 95% CI: −1.6 to −1.2) was found during follow‐up. The change in septal thickness was minimal and not statistically significant. Two procedure‐related deaths were documented, and complete heart block occurred in eight patients.ConclusionsRadiofrequency septal ablation is effective and safe for relieving LVOT obstruction and improving exercise capacity in patients with HOCM.
Impact of environment color on individual responses in public spaces of shopping malls
Authors: Yi Fashu , Kang Jian 
Published: February 2020

AbstractThis study aims to explore the specific impact of a color's hue, saturation, and brightness value on people's evaluation, behavior, and emotions in the public space of existing shopping malls. Following a field investigation, color composition and distribution characteristics in the public spaces of shopping malls are summarized. In the real scenes, the hues of colors are mainly warm colors, with some supplemented by blue. The saturation of the majority colors, which are almost grayish colors, is lower than 33% and their brightness is very wide and evenly distributed. An experiment was then conducted in the laboratory, wherein photos taken and sounds recorded on‐site were shown to participants; the participants were then asked to answer questionnaires based on the pleasure‐arousal‐dominance emotion and approach‐avoidance behavior theories. The results showed that hue has a weak effect on individual responses, whereas saturation was found to have a significant effect. Moreover, the brightness difference between colors can cause a change in satisfaction, behavior intention, and emotion. Additionally, in the public spaces of shopping malls, the red color is more associated with embodied meaning, whereas the green color is more associated with referential meaning, in which different objects have significantly different influences.
The mosaic distribution pattern of two sister bush‐cricket species and the possible role of reproductive interference
Authors: Dorková Martina , Krištín Anton , Jarčuška Benjamín , Kaňuch Peter 
Published: February 2020

AbstractReproductive interference can shape regional distribution patterns in closely related species, if prezygotic isolation barriers are weak. The study of such interaction could be more challenging in nuptial gift‐giving species due to the direct nutritional effects on both sexes of both species during copulation. We mapped the distribution of two sister bush‐cricket species, Pholidoptera aptera and Pholidoptera transsylvanica, at the northern margin of their overlapping ranges in Europe, and with a behavioral experiment, we tested the possibility of heterospecific mating. We found a very rare coexistence of species locally (0.5%, n = 391 sites) with mostly mutually exclusive distribution patterns, resulting in a mosaic pattern of sympatry, whereas they occupied the same climate niche in forest‐dominated mountain landscape. Over 14 days of a mating experiment with seven mixed groups of conspecifics and heterospecifics (n = 56 individuals in total), the number of received spermatophores per female was 3–6 in P. aptera and 1–7 in P. transsylvanica. In total, we found 8.1% of heterospecific copulations (n = 99 transferred spermatophores with genetic identification of the donor species), while we also confirmed successful transfer of heterospecific sperms into a female's reproductive system. Because bush‐cricket females also obtain required nutrition from a heterospecific spermatophylax what should increase their fitness and fecundity, we suggest that their flexibility to mate with heterospecifics is beneficial and drives reproductive interference. This may substantially limit the reproductive success of the less frequent species (P. transsylvanica), coupled with eventual detrimental effects from hybridization, and result in the competitive exclusion of that species from their areas of coexistence.
Mineralocorticoid receptor antagonist use following heart failure hospitalization
Authors: Duran Jason M. , Gad Shady , Brann Alison , Greenberg Barry 
Published: February 2020

AbstractAimsPatients hospitalized for heart failure (HF) are at increased risk for events post‐discharge. Mineralocorticoid receptor antagonists (MRAs) improve the clinical course of patients with HF with reduced ejection fraction. We assessed MRA use in high‐risk patients following an HF hospitalization to determine rate of MRA prescription, likelihood of drug continuation post‐discharge, reasons for discontinuation, and association between MRA maintenance and outcomes.Methods and resultsPatients admitted to our hospital system between 2011 and 2013 were identified retrospectively through automated search of electronic medical records for appropriate ICD 9 and 10 codes. Patients with left ventricular ejection fraction <40%, New York Heart Association class III–IV symptoms, >1 year of follow‐up and no contraindication to MRA use were included. Of 271 patients meeting inclusion criteria, 105 (38.7%) were prescribed an MRA on discharge from index admission. Over a median follow‐up of 3.12 ± 0.09 years, 70 (66.7%) continued MRA therapy, while 35 (33.3%) discontinued MRA therapy. Hyperkalemia, which occurred in 43 of the 105 patients (40.1%), was the most frequent cause of MRA discontinuation. Patients who maintained MRA therapy had significantly less all‐cause, cardiovascular, and HF hospitalizations and significantly better survival compared with those who discontinued drug.ConclusionsA minority of HF with reduced ejection fraction patients who were eligible for an MRA received them following HF hospitalization and nearly a third of them discontinued drug. Patients who discontinued an MRA were more likely to be hospitalized or die during follow‐up. These findings indicate a need for better strategies to increase MRA prescription and maintain therapy following a hospitalization for HF.
Viscero‐visceral hyperalgesia in dysmenorrhoea plus previous urinary calculosis: Role of myofascial trigger points and their injection treatment in the referred area
Authors: Costantini Raffaele , Affaitati Giannapia , Fiordaliso Michele , Giamberardino Maria Adele 
Published: February 2020

AbstractBackgroundWomen with dysmenorrhoea plus symptomatic urinary calculosis experience enhanced pain and referred muscle hyperalgesia from both conditions than women with one condition only (viscero‐visceral hyperalgesia). The study aimed at verifying if enhanced dysmenorrhoea persists after urinary stone elimination in comorbid women and if local anaesthetic inactivation of myofascial trigger points (TrPs) in the lumbar area (of urinary pain referral) also relieves dysmenorrhoea.MethodsThirty‐one women with dysmenorrhoea plus previous urinary calculosis (Dys+PrCal) and lumbar TrPs, and 33 women with dysmenorrhoea without calculosis (Dys) underwent a 1‐year assessment of menstrual pain and muscle hyperalgesia in the uterus‐referred area (electrical pain threshold measurement in rectus abdominis, compared with thresholds of 33 healthy controls). At the end of the year, 16 comorbid patients underwent inactivation of TrPs through anaesthetic injections, whereas the remaining 12 received no TrP treatment. Both groups were monitored for another year at the end of which thresholds were re‐measured.ResultsIn year1, Dys+PrCal presented significantly more painful menstrual cycles and lower abdominal thresholds than Dys, thresholds of both groups being significantly lower than normal (p < .001). Anaesthetic treatment versus no treatment of the lumbar TrP significantly reduced the number of painful cycles during year2 and significantly increased the abdominal thresholds (p < .0001).ConclusionViscero‐visceral hyperalgesia between uterus and urinary tract may persist after stone elimination due to nociceptive inputs from TrPs in the referred urinary area, since TrPs treatment effectively reverses the enhanced menstrual symptoms. The procedure could represent an integral part of the management protocol in these conditions.SignificanceA past pain process from an internal organ can continue enhancing pain expression from a painful disease in another neuromerically connected organ (viscero‐visceral hyperalgesia) if secondary myofascial trigger points (TrPs) developed in the referred area at the time of the previous visceral disease. Inactivation of these TrPs reverts the enhancement. Assessment and treatment of TrPs in referred areas from past visceral pain conditions should be systematically carried out to better control pain from current diseases in other viscera.