bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Kinerja Keuangan Terhadap Closing Price Pada Perusahaan Manufaktur yang Terdaftar di Bei (2013-2016)
Authors: Siswanti Dewi , Ahmad Ahmad 
Published: November 2019

This study aims to determine the effect of financial performance of the closing price on the company manufacturing the listed in BEI (2013-2016). The sub sector manufacturing company selected is plastic and packaging, there are 11 company that totaly company of this categori, with regard sequence and completness of the data financial statements available in the IDX continuosly from 2013-2016. Correlation coefficient between 7 independent variables with closing price of 0,859 so that the coefficient of determinant r2 0,738. This mean the ability of variable X (Current Rate, DER, ROE, GPM, OPM, NPM and EPS) in explaining the diversity of varible Y (Closing price) for 73,8%. While the rest of the 26,2 described by other variables. Variable partial most positive effect is NPM, while the most small effect is GPM, two variable which ROE and OPM influence inversely, namely the reduction of the coefficient of the raise the variable Y.
Ekosistem Bisnis Wisata Halal dalam Perspektif Maqasid Syariah
Authors: Nugroho Lucky , Utami Wiwik , Doktoralina Caturida Meiwanto 
Published: November 2019

Tujuan dari penelitian ini adalah memberikan masukkan kepada para pemangku kepentingan terkait dengan strategi ekosistem bisnis wisata halal dalam perspektif syariah. Penelitian ini adalah konspetual paper dengan menggunakan metode kualitatif yang didukung kajian-kajian pustaka untuk menjelaskan fenomena yang terjadi dengan pembatasan pertanyaan penelitian (1) Apa yang dimaksud dengan Maqasid Syariah?; (2) Apa yang dimaksud dengan strategi ekosistem bisnis?; (3) Bagaimana meningkatkan daya saing pariwisata di Indonesia melalui ekosistem bisnis wisata halal?. Sesuai dengan tujuan pemerintah, yaitu menjadikan Indonesia sebagai pusat keuangan syariah dan potensi mayoritas Muslim Indonesia, maka ekosistem bisnis wisata halal dapat dijadikan salah satu strategi prioritas program pemerintah untuk menarik wisatawan mancenagera datang ke Indonesia melalui peningkatan layanan dan infrastruktur yang berlandaskan prinsip maqasid syariah.
Capital Structure, Business Risk and Corporate Performance (Case Study on Construction and Real Estate Sector)
Authors: Sutrisno Sutrisno 
Published: November 2019

The purpose of this study is to examine the effect of capital structure and business risk on corporate performance. This study also examined the effect of non debt tax shield (NDTS) and sales growth (SG) on corporate performance with firm size (SIZ) as a control variable. Corporate performance is measured by return on assets (ROA), while capital structure is measured by debt to equity ratio (DER), and business risk meausred by degree of operating leverage (DOL). The population in this study is a company engaged in the construction and real estate sector that listed on the Indonesia Stock Exchange. The samples taken were 32 companies with purposive sampling. observations period for 3 years (2015-2017). Data is processed using ordinary least square (OLS). The results showed on the significance level 0.10, capital structure (DER) had a significant but negative effect on corporate performance. Business risk (DOL) and sales growth (SG) have a significant and positive effect on performance. While non debt tax shield (NDTS) and firm size (SIZ) have no significant effect on corporate performance.
Fewer hospitalizations and prolonged technique survival with Home Hemodialysis– a matched cohort study from the Swedish Renal Registry
Authors: Rydell Helena , Ivarsson Kerstin , Almquist Martin , Clyne Naomi , Segelmark Mårten 
Published: November 2019

Abstract
Background Patients on home hemodialysis (HHD) exhibit superior survival compared with patients on institutional hemodialysis (IHD) and peritoneal dialysis (PD). There is a sparsity of reports comparing morbidity between HHD and IHD or PD and none in a European population. The aim of this study is to compare morbidity between modalities in a Swedish population. Methods The Swedish Renal Registry was used to retrieve patients starting on HHD, IHD or PD. Patients were matched according to sex, age, comorbidity and start date. The Swedish Inpatient Registry was used to determine comorbidity before starting renal replacement therapy (RRT) and hospital admissions during RRT. Dialysis technique survival was compared between HHD and PD. Results RRT was initiated with HHD for 152 patients; these were matched with 608 patients with IHD and 456 with PD. Patients with HHD had significantly lower annual admission rate and number of days in hospital. (median 1.7 admissions; 12 days) compared with IHD (2.2; 14) and PD (2.8; 20). The annual admission rate was significantly lower for patients with HHD compared with IHD for cardiovascular diagnoses and compared with PD for infectious disease diagnoses. Dialysis technique survival was significantly longer with HHD compared with PD. Conclusions Patients choosing HHD as initial RRT spend less time in hospital compared with patients on IHD and PD and they were more likely than PD patients, to remain on their initial modality. These advantages, in combination with better survival and higher likelihood of renal transplantation, are important incentives for promoting the use of HHD.
Signatures containing miR-133a identified by large scale miRNA profiling in bladder cancer
Authors: Jiang Shuai , Zhu Miaojun , Xiang Zhuoyi , Zhang Fengwu , Hou Jun , Wang Hang , Liu Li , Wang Hailong , Tang Tom , Tan Ruoying , Li Zengxia , Guo Jianming 
Published: November 2019

Abstract
Background: Identifying bladder cancer-specific miRNA expression signatures by large scale miRNA profiling Methods：30 bladder cancer (BC) tissue samples and matched adjacent normal bladder tissue samples from patients with BC were collected and were divided into two groups； a training group and a blind testing group. Expressions of 1900 miRNAs and controls were detected in a BC miRNA pool and in a normal miRNAs pool, respectively. 380 differential expressed miRNAs between the BC miRNA pool and the normal miRNA pool were selected. The primers for detecting the 380 selected miRNAs and controls were used to generate one 384-well panel. This panel was used to profile miRNA expression of each individual sample in the training group and in the blind testing group. Data analysis was performed using a machine learning approach of a support vector machine classifier with a Student's t-test feature selection procedure. Results： We identified signatures consisting of three or four miRNAs that could distinguish BC from normal controls with an accuracy of 100% in the training model and an accuracy of over 95% in the blind test. All identified signatures contain hsa-miR-133a. We also revealed that the miRNA183-96 cluster and the miR200 cluster are both significantly up-regulated in BC. Conclusions：The identified signatures containing hsa-miR-133a could be used as biomarkers in the diagnosis and prognosis of BC.
The roles of metabolic pathways in maintaining primary dormancy of Pinus koraiensis seeds
Authors: Song Yuan , Zhu Jiaojun 
Published: November 2019

Abstract
Background: Korean pine seeds have primary dormancy following dispersal, leading to poor seed germination and seedling establishment. Metabolic homeostasis determines whether the seeds are dormant or non-dormant. However, the specific metabolic pathways that maintain the primary dormancy of pine seeds are poorly understood.
Results: Metabolic analysis was employed on the embryos of PDRS (seeds released from primary dormancy) and PDS (primary dormant seeds) on days 0, 5 and 11 after incubation under a germination-inductive temperature. A larger metabolic switch occurred in PDRS embryos from days 0 to 11. The contents of ninety metabolites were significantly changed from days 0 to 5, 83% of which (including most sugars, organic acids and amino acids) increased, reflecting that biosynthetic metabolism processes are initiated. The contents of ninety-two metabolites showed distinct variations from days 5 to 11, 71% of which (including most organic acids and almost all amino acids) reduced substantially. Fructose 6-phosphate, inositol-3-phosphate, 3-phosphoglyceric and D-glucose-6-phosphate contents showed the most decrease with decreasing 409-, 75-, 58- and 41-fold, indicating that the glycolysis and tricarboxylic acid (TCA) cycle strongly slowed down. The contents of the most metabolites in PDS embryos also displayed a relatively larger alteration only from days 0 to 5. Although 64% of metabolites increased from days 0 to 5, their levels were still lower compared with PDRS embryos. Furthermore, most metabolites were not further accumulated from days 5 to 11. Unlike PDRS embryos, almost all amino acids in PDS embryos did not exhibit a substantial decrease from days 5 to 11. Also, there was not a major decrease in the levels of metabolites involved mainly in glycolysis and TCA cycle, while some intermediates even increased.
Conclusions: The attenuated biosynthetic metabolism processes, the lower utilization rate of amino acids and the higher operation rate of glycolysis and TCA in embryos maintain primary dormancy.
The pathogen Moniliophthora perniciosa promotes differential proteomic modulation of cacao genotypes with contrasting resistance to witches´ broom disease.
Authors: Santos Everton Cruz , Pirovani Carlos Priminho , Correa Stephany , Micheli Fabienne , Gramacho Karina P 
Published: November 2019

Abstract
Background: Witches’ broom disease (WBD) of cacao (Theobroma cacao L.), caused by Moniliophthora perniciosa, is the most important limiting factor for the cacao production in Brazil. Hence, the development of cacao genotypes with durable resistance is the key challenge for control the disease. Proteomic methods are often used to study the interactions between hosts and pathogens, therefore helping classical plant breeding projects on the development of resistant genotypes. The present study compared the proteomic alterations between two cacao genotypes standard for WBD resistance and susceptibility, in response to M. perniciosa infection at 72 hours and 45 days post-inoculation; respectively the very early stages of the biotrophic and necrotrophic stages of the cacao x M. perniciosa interaction. Results: A total of 554 proteins were identified, being 246 in the susceptible Catongo and 308 in the resistant TSH1188 genotypes. The identified proteins were involved mainly in metabolism, energy, defense and oxidative stress. The resistant genotype showed more expressed proteins with more variability associated with stress and defense, while the susceptible genotype exhibited more repressed proteins. Among these proteins, stand out pathogenesis related proteins (PRs), oxidative stress regulation related proteins, and trypsin inhibitors. Interaction networks were predicted, and a complex protein-protein interaction was observed. Some proteins showed a high number of interactions, suggesting that those proteins may function as cross-talkers between these biological functions. Conclusions: We present the first study reporting the proteomic alterations of resistant and susceptible genotypes in the T. cacao x M. perniciosa pathosystem. The important altered proteins identified in the present study are related to key biologic functions in resistance, such as oxidative stress, especially in the resistant genotype TSH1188, that showed a strong mechanism of detoxification. Also, the positive regulation of defense and stress proteins were more evident in this genotype. Proteins with significant roles against fungal plant pathogens, such as chitinases, trypsin inhibitors and PR 5 were also identified, and they may be good resistance markers. Finally, important biological functions, such as stress and defense, photosynthesis, oxidative stress and carbohydrate metabolism were differentially impacted with M. perniciosa infection in each genotype.
Comparison of open liver resection and RFA for the treatment of solitary 3-5 cm hepatocellular carcinoma: a retrospective study
Authors: Lei Jianyong , Yan LN , Li DJ , Wang WT 
Published: November 2019

Abstract
Aim: The goal of this study was to compare the postoperative results of liver resection and radiofrequency ablation (RFA) for the treatment of small hepatocellular carcinoma (HCC) (3-5 cm).
Patients and methods: We retrospectively collected 122 patients with small solitary HCC treated at our center from Jan 2011 to Dec 2015, with diameters in the range of 3-5 cm. According to the treatment program received at our center, they were divided into the liver resection group (72 patients) and the RFA group (50 patients).
Result : In comparison with the RFA group, the resection group had a longer operative time, and greater intra-operative blood loss (P<0.01), more hepatic inflow occlusion , and longer postoperative hospital stay (P<0.01). The 1-, 3-, and 5-year expected overall survival rates and tumor-free survival rates were comparable between the two groups. Cox regression analysis showed that resection or RFA was not a significant risk factor for overall or tumor-free survival for HCC.
Conclusions : For solitary HCC of 3-5 cm in diameter, RFA can achieve better in-hospital clinical results and similar long-term outcomes, and RFA can be considered for wide application, especially for central cases.
Magnitude and Associated Factors of Delayed Immunization Among Children Aged 11 -23 Months in Edagahamus Town, Tigray, Ethiopia, 2018.
Authors: Hagos Merhawit Gebremeskel , Gebremeskel Teferi Gebru , Kassahun Selam Shushay , Gebrezgi Birhane Hailu , Woldegebriel Manay Kifle 
Published: November 2019

Abstract
Background: Delayed immunization is a major public health problem that is associated with vaccine-preventable disease epidemics. In Ethiopia, many children don’t receive the benefits of age-appropriate immunization; thus more than 90% of child deaths are largely due to preventable communicable diseases. Therefore, the aim of this study to assess the magnitude and factors associated with delayed immunization among 12 -23 months old children in Edagahamus Town, Tigray, Ethiopia, and 2018 G.C.
Methods: A community-based Cross-Sectional study was carried out on July1-30, 2018. A simple random sampling method was used to select study participants. Information was collected using a structured, pre-tested questionnaire. The date of vaccinations was obtained from children’s immunization cards and timeliness assessed based on the recommended age ranges. Data were entered and analyzed using SPSS version 20.0. Variable with P-value < 0.2 in bivariate was exported to multivariate. The strength of association was identified using the odds ratio with a 95 % confidence interval (CI) and the P-value of <0.05 in multivariate was taken statistically significant.
Results: In this study, the overall magnitude of delayed immunization was 29.5% (95%CI 26.7-45). Private firm work of mothers (AOR=0.205 95% CI 0.068-0.617), Mothers who attend tertiary education (AOR 0.169, 95% CI 0.032-0.882), and secondary education (AOR 0.269, 95% CI 0.114-0.636) had the protective effect of delayed immunization. But sickness of a child (AOR= 11.8, 95% CI 6.16-22.65) was a risk for delayed immunization.
Conclusions: From the study, it is concluded that the magnitude of delayed immunization for children aged 12-23 months is high (29.5%) in Edagahamus. Delayed immunizations of children were predicted by the Mother's occupation, education, and Mother’s consideration in the child’s wellness to take the vaccine.
Discrimination of mediastinal metastatic lymph nodes in NSCLC based on radiomic features in different phases of CT imaging
Authors: Sha Xue , Gong Guan Zhong , Qiu Qing Tao , Duan Jing Hao , Li Deng Wang , Yin Yong 
Published: November 2019

Abstract
Background: We aimed to develop radiomic models based on different phases of computed tomography (CT) imaging and to investigate the efficacy of models for diagnosing mediastinal metastatic lymph nodes (LNs) in non-small cell lung cancer (NSCLC).
Methods: Eighty-six NSCLC patients were enrolled in this study, and we selected 231 mediastinal LNs confirmed by pathology results as the subjects which were divided into training (n=163) and validation cohorts (n=68). The regions of interest (ROIs) were delineated on CT scans in the plain phase, arterial phase and venous phase, respectively. Radiomic features were extracted from the CT images in each phase. A least absolute shrinkage and selection operator (LASSO) algorithm was used to select features, and multivariate logistic regression analysis was used to build models. We constructed six models (orders 1-6) based on the radiomic features of the single- and dual-phase CT images. The performance of the radiomic model was evaluated by the area under the receiver operating characteristic curve (AUC), sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV).
Results: A total of 846 features were extracted from each ROI, and 10, 9, 5, 2, 2, and 9 features were chosen to develop models 1-6, respectively. All of the models showed excellent discrimination, with AUCs greater than 0.8. The plain CT radiomic model, model 1, yielded the highest AUC, specificity, accuracy and PPV, which were 0.926 and 0.925; 0.860 and 0.769; 0.871 and 0.882; and 0.906 and 0.870 in the training and validation sets, respectively. When the plain and venous phase CT radiomic features were combined with the arterial phase CT images, the sensitivity increased from 0.879 and 0.919 to 0.949 and 0979 and the NPV increased from 0.821 and 0.789 to 0.878 and 0.900 in the training group, respectively.
Conclusions: All of the CT radiomic models based on different phases all showed high accuracy and precision for the diagnosis of LN metastasis (LNM) in NSCLC patients. When combined with arterial phase CT, the sensitivity and NPV of the model was be further improved.
Microscopic features of small bowel mucosa of patients with Crohn’s disease
Authors: cui yun , Lu Shi-yuan , Xu Jie , Peng Yan-shen , Miao Qi , wang xiao-qing , Chen Xiao-yu , Ran Zhi-hua 
Published: November 2019

Abstract
Background Double-balloon enteroscopy enables performing numerous small bowel biopsies for pathologic analysis. However, most histopathological characteristics of Crohn’s disease are non-specific characteristics. We aimed to explore the small bowel mucosal histopathologic characters of Crohn’s disease and identify some disease-specific changes. Methods We included 253 patients without tumors and grouped them into Crohn’s disease, suspected Crohn’s disease, and non-Crohn’s disease groups. These patients underwent double-balloon endoscopy examination and small bowel biopsy at Renji Hospital, Shanghai. All histopathological sections were reviewed, and >20 histopathological parameters were assessed. Immunohistochemistry was conducted when necessary. Results There were different forms of granulomatous lymphangitis on the small bowel mucosa in Crohn’s disease. They showed as various macrophages or epithelioid cells in the lumina of lymphatics or in the center of the villi with or without evident obstruction. These features were only observed in Crohn’s disease patients. Furthermore, they were correlated with granuloma and lymphangiectasia. Additionally, 15 other features showed significant differences among the three groups, and Crohn’s disease patients showed an average of almost seven histopathological characteristics. Conclusions We described the detailed morphologies of granulomatous lymphangitis on the small bowel mucosa and recommend it as a useful histopathological feature for the diagnosis of Crohn’s disease. In terms of specificity and sensitivity, it was superior to non-caseating epithelioid granuloma.
Transcriptome analysis of Pueraria candollei var. mirifica for gene discovery in the biosyntheses of isoflavones and miroestrol
Authors: Suntichaikamolkul Nithiwat , Tantisuwanichkul Kittiya , Prombutara Pinidphon , Kobtrakul Khwanlada , Zumsteg Julie , Wannachart Siriporn , Schaller Hubert , Yamazaki Mami , Saito Kazuki , De-eknamkul Wanchai , Vimolmangkang Sornkanok , Sirikantaramas Supaart 
Published: November 2019

Abstract
Background: Pueraria candollei var. mirifica, a Thai medicinal plant used traditionally as a rejuvenating herb, is known as a rich source of phytoestrogens, including isoflavonoids and the highly estrogenic miroestrol and deoxymiroestrol. Although these active constituents in P. candollei var. mirifica have been known for some time, actual knowledge regarding their biosynthetic genes remains unknown. Results: Miroestrol biosynthesis was reconsidered and the most plausible mechanism starting from the isoflavonoid daidzein was proposed. A de novo transcriptome analysis was conducted using combined P. candollei var. mirifica tissues of young leaves, mature leaves, tuberous cortices, and cortex-excised tubers. A total of 166,923 contigs was assembled for functional annotation using protein databases and as a library for identification of genes that are potentially involved in the biosynthesis of isoflavonoids and miroestrol. Twenty-one differentially expressed genes from four separate libraries were identified as candidates involved in these biosynthetic pathways, and their respective expressions were validated by quantitative real-time reverse transcription polymerase chain reaction. Notably, isoflavonoid and miroestrol profiling generated by LC-MS/MS was positively correlated with expression levels of isoflavonoid biosynthetic genes across the four types of tissues. Moreover, we identified R2R3 MYB transcription factors that may be involved in the regulation of isoflavonoid biosynthesis in P. candollei var. mirifica. To confirm the function of a key-isoflavone biosynthetic gene, P. candollei var. mirifica isoflavone synthase identified in our library was transiently co-expressed with an Arabidopsis MYB12 transcription factor (AtMYB12) in Nicotiana benthamiana leaves. Remarkably, the combined expression of these proteins led to the production of the isoflavone genistein. Conclusions: Our results provide compelling evidence regarding the integration of transcriptome and metabolome as a powerful tool for identifying biosynthetic genes and transcription factors possibly involved in the isoflavonoid and miroestrol biosyntheses in P. candollei var. mirifica.