bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increase in Genetic Counseling and Testing Referrals After Breast Cancer Pathway Implementation
Authors: Graff Stephanie L. , Holder Jared M. , Sears Lindsay E. , Kurbegov Dax 
Published: July 2020

PURPOSE: Genetic counseling and testing (GC/T) for breast cancer–associated genetic mutations are important components in the appropriate management of newly diagnosed breast cancer. We initiated pathways to help appropriately select patients who meet criteria for GC/T referral (GC/T-R) across the Sarah Cannon Cancer Institute Network. This study evaluated physician pathway training as a means to improve access to GC/T-R. METHODS: In this retrospective, observational study, we collected data from 7 regions across 6 states, identifying 3,113 patients eligible for GC/T. Patients were divided into 3 defined cohorts: patients treated before implementation of pathways (n = 988), patients treated by non-pathway physicians after pathways were established (n = 1,094), and patients treated by pathway-trained physicians (n = 1,031). Pathways were established in March 2016. Nurse navigators documented eligible patients who were referred for GC/T within a care coordination software system. RESULTS: Eligible patients were referred for GC/T 71.77% of the time if treated on pathways and only 36.47% of the time if treated off pathways. On-pathway patients eligible for GC/T also received testing referral at a higher rate than pre-pathway patients (21.36%). CONCLUSION: After implementation of pathways and appropriate training of physicians on those pathways, GC/T-R among appropriate patients significantly improved. Pathway training represents a potential solution to improve GC/T-R among patients with breast cancer.
Power insensitive surface-normal electroabsorption modulators
Authors: Grillanda Stefano , Hu Ting-Chen , Neilson David , Earnshaw Mark 
Published: July 2020

Surface-normal electroabsorption modulators (SNEAMs) have unique
electro-optic modulation properties; however, their behavior and
performance at high light intensity is affected by thermal
nonlinearities that take place in the modulator active volume. Here we
show a novel, to the best of our knowledge, approach to make SNEAMs
insensitive to optical power without the use of power-hungry heaters
or feedback control systems. By passively compensating for the
thermo-optic dependence of the SNEAM resonant cavity, we obtain an
eight-fold reduction in the wavelength shift of the SNEAM response at
4 dBm of input power. Furthermore, we show no appreciable degradation
in the SNEAM eye diagram at 25 Gbit/s, when the input power is
increased up to 2 dBm, which is about four times higher than in
conventional SNEAMs.
Spatial images from temporal data
Authors: Turpin Alex , Musarra Gabriella , Kapitany Valentin , Tonolini Francesco , Lyons Ashley , Starshynov Ilya , Villa Federica , Conca Enrico , Fioranelli Francesco , Murray-Smith Roderick , Faccio Daniele 
Published: July 2020

Traditional paradigms for imaging rely on the use of a spatial structure, either in the detector (pixels arrays) or in the illumination (patterned light). Removal of the spatial structure in the detector or illumination, i.e., imaging with just a single-point sensor, would require solving a very strongly ill-posed inverse retrieval problem that to date has not been solved. Here, we demonstrate a data-driven approach in which full 3D information is obtained with just a single-point, single-photon avalanche diode that records the arrival time of photons reflected from a scene that is illuminated with short pulses of light. Imaging with single-point time-of-flight (temporal) data opens new routes in terms of speed, size, and functionality. As an example, we show how the training based on an optical time-of-flight camera enables a compact radio-frequency impulse radio detection and ranging transceiver to provide 3D images.
Update on molecular diagnosis of human leptospirosis
Authors: Techawiwattanaboon Teerasit , Patarakul Kanitha 
Published: July 2020

Abstract

Background
Leptospirosis, caused by pathogenic Leptospira spp., is a widespread zoonotic disease worldwide. Early diagnosis is required for proper patient management and reducing leptospirosis morbidity and mortality.

Objective
To summarize current literature regarding commonly used and new promising molecular approaches to Leptospira detection and diagnostic tests of human leptospirosis.

Method
The relevant articles in Leptospira and leptospirosis were retrieved from MEDLINE (PubMed) and Scopus.

Results
Several molecular techniques have been developed for diagnosis of human leptospirosis. Polymerase chain reaction-based techniques targeting on either lipL32 or 16S rRNA (rrs) gene are most commonly used to detect leptospiral DNA in various clinical specimens. Whole blood and urine are recommended specimens for suspected cases in the first (acute) and the second (immune) phases, respectively. Isothermal amplification with less expensive instrument is an alternative DNA detection technique that may be suitable for resource-limited laboratories.

Conclusion
Detection of leptospiral DNA in clinical specimens using molecular techniques enhances sensitivity for diagnosis of leptospirosis. The efficient and robust molecular detection especially in the early leptospiremic phase may prompt early and appropriate treatment leading to reduced morbidity and mortality of patients with leptospirosis.
The Practical Syllogism and Practical Cognition in Aristotle
Authors: Harbin R. Kathleen 
Published: July 2020

Abstract
Prevailing interpretations of Aristotle’s use of syllogistic language outside the Organon hold that he offers a single, comprehensive theory of the practical syllogism spanning his ethical and biological works. These comprehensive theories of the practical syllogism are plausible neither philosophically nor as interpretations of Aristotle. I argue for a multivocal account of the practical syllogism that distinguishes (1) Aristotle’s use of syllogistic language to explain aspects of his account of animal motion in MA from (2) his use of syllogistic language to explain aspects of his account of the distinctive practical cognition of the phronimos in EN. I offer a novel account of the role of syllogistic language in ethics, arguing that it elucidates a nuanced account of universals and particulars in ethics according to which acting virtuously requires an understanding of underlying universal values and a capacity to relate them to concrete, particular features of our circumstances.
Possibilities of Obtaining Renewable Energy in Dairy Farming
Authors: Borek Kinga , Romaniuk Wacław 
Published: July 2020

Abstract
Modern livestock facilities necessary in the production of milk, meat or other animal products should be constructed with environmental protection in mind, while ensuring high quality of production and animal welfare. The high level of mechanization in modern dairy farms, including automated and robotic processes, allows obtaining high quality raw material (e.g. milk), and significantly increasing labor and production efficiency. In addition, the use of photovoltaic (PV) panels, heat recovery from milk and obtaining biogas from the manure fermentation process, contributes to large energy savings on the farm. Excess of natural fertilizers, which are an animal byproduct, can be used as a substrate for methane fermentation. The presented examples of obtaining renewable energy allow improving the economic efficiency of animal production. They also ensure appropriate environmental conditions through the innovative management of natural fertilizers.
Analysis of Failures and Reliability Model of Farm Tractors
Authors: Napiórkowski Jerzy , Gonera Jarosław 
Published: July 2020

Abstract
Farm tractors due to the nature of their work are exposed to a substantial risk of failures. The issues of their reliability are unusually significant in the aspect of the time limit of realisation of agricultural works in agrotechnical seasons. Nowadays, tractors provided for agriculture have increasingly complex functional units. The aim of the paper was to analyse reliability of presently produced farm tractors. Three tractor makes were evaluated and the analysis of failures was carried out with regard to functional units. Based on the obtained results, the average time of correct functioning and refreshment times and availability of particular tractor makes were determined. It was stated that the obtained empirical data of the correct functioning time and refreshment time may be well described with exponential functions. Significant differences in the values that determine the average time of correct functioning and duration time of refreshment obtained by tractors of the investigated makes were found. From among particular functional units, electric and hydraulic systems were the most often damaged, regardless the tractor make.
Cribado y diagnóstico prenatal de anomalías genéticas: recomendaciones de consenso SEGO, SEQCML, AEDP
Authors: Prieto-García Belén , Adiego Begoña , Suela Javier , Martín Inmaculada , Santacruz Belén , García-Planells Javier , Gil Mar , González Concepción , Eva Barrenechea  
Published: July 2020

Resumen
El objetivo de este trabajo es difundir las recomendaciones del consenso entre las sociedades científicas SEGO, SEQCML y AEDP sobre cribado y diagnóstico prenatal de anomalías genéticas, así como una propuesta de indicadores de evaluación, desde una perspectiva de mejora de cada uno de los procesos que constituyen el campo de aplicación de las estrategias actuales de cribado: bioquímico, ecográfico y genético. Asimismo, se recogen recomendaciones relacionadas con los procesos invasivos de diagnóstico prenatal, incluyendo tanto las técnicas de recogida de muestra como las aplicables a su posterior análisis genético. Perspectiva: Se propone unificar criterios e indicadores a nivel nacional, con evaluaciones periódicas. Asimismo, sería muy recomendable establecer una estrategia de cribado prenatal a nivel nacional, dotada con recursos que aseguren la auditoría periódica de dichos indicadores y de los procedimientos diagnósticos, con supervisión por las administraciones sanitarias. Los protocolos deberían ser revisados periódicamente para adaptarse a nuevas tecnologías coste-efectivas.
The role of communities in Uganda’s mother tongue-based education: Perspectives from a literacy learning enhancement project in Arua district
Authors: Ngaka Willy 
Published: July 2020

AbstractThis paper explores some of the factors that limit the effectiveness of Uganda’s mother tongue-based education policy, where instruction in lower primary classes is provided in the mother tongue. Using socio-cultural and ethnographic lenses, the paper draws from the experiences of a study implemented by a Ugandan NGO in one primary school in Arua district. Findings revealed weaknesses in implementation of the MTBE policy, highlighting deficiencies in the training of teachers, and lack of sensitization of local communities to the value of MTBE. The study also highlights the need for greater involvement of many kinds of stakeholder, and in particular, it focuses on how communities can be encouraged to work together with schools. A clearer understanding of what literacy involves, and how subjects can be taught in poorly-resourced communities, can be gained by considering the contribution of funds of local knowledge and modes of expression that build on local cultural resources. However, the strategies proposed are insufficient given the flawed model of primary education that the present MTBE policy embodies. A reenvisioning of how MTBE articulates with English-medium education is also needed. Substantial rethinking is needed to address target 4.6 of SDG 4 (UNDP, Transforming our world: The 2030 agenda for sustainable development.https://sustainabledevelopment.un.org/post2015/transformingourworld(accessed 30 November 2015), 2015) which aims to ensure that “all youth and a substantial proportion of adults achieve literacy and numeracy by 2030”.
On the role of collisions with meteoroids in splitting and acceleration of heliocentric velocity of comets
Authors: Guliyev Ayyub , Guliyev Rustam 
Published: July 2020

Abstract
The hypothesis on the role of the meteoroid impacts in the comet nuclei splitting as well as acceleration of their heliocentric velocity are considered. Inclinations of the orbits of split comets relative to the movement planes of 100 known meteoroid streams are calculated. The analysis is carried out for the cases: when the cometary nodes are located from the meteoroids orbit < 0.1 AU; MOID-values less than 0.1 AU. In the case of split long-period comets irregularity (maximum near 180°) of the distribution of the inclinations has been found. Comets, constituting this maximum, could have head-on collisions with meteoroids. A similar analysis is carried out relatively to the hyperbolic comets (HCs). Analysis is based on the assumption that the acceleration of the heliocentric velocities of the comet also is caused by collisions with meteoroids. The inclinations of the orbits of 300 HCs relative to 100 known meteoroid streams have the significant maxima in the interval of 90°− 101.5°. Acceleration of comet velocity might be the result of “slanting” collisions with meteoroids.
LncRNA SNHG15 regulates osteosarcoma progression in vitro and in vivo via sponging miR-346 and regulating TRAF4 expression
Authors: Chen Xuewu , Xu Hongguang 
Published: July 2020

AbstractOsteosarcoma (OS) is a common primary malignant bone tumor around the world. It has been reported that long noncoding RNAs (lncRNAs) take part in diverse pathological processes of OS; however, the mechanism remains unknown. This study aimed to uncover the profile of lncRNAsmall nucleolar RNA host gene 15(SNHG15), its biological function, and its potential involvement in the mechanism of OS progressionin vitroandin vivo. The expression of SNHG15 and TRAF4 was promoted in OS tissues opposite for that of miR-346. The silencing of SNHG15 limited the proliferation, invasion, and enhanced apoptosis of SaoS2 and HOS cells. Moreover, the putative binding sites between miR-346 and SNHG15 or TRAF4 were predicted by starBase and Targetscan software online, individually. Also, miR-346 deletion reversed the positive effects of SNHG15 elimination on proliferation, apoptosis, and invasion in cells. In addition, the upregulation of TRAF4 disrupted the biofunctional results from miR-346 promotion subsequently. Finally, SNHG15 knockdown repressed OS tumor growth in a xenograft tumor model. SNHG15 enhanced the progression of OS by regulating the miR-346/TRAF4 axisin vitroandin vivo.
Coexisting flavonoids and administration route effect on pharmacokinetics of Puerarin in MCAO rats
Authors: Li Pengyue , Zhong Linying , Yang Linjie , Bai Jie , Lu Yang , Du Shouying 
Published: July 2020

AbstractA pharmacokinetic comparison was made to evaluate the influence from other components in the Radix Puerariae Extract on pharmacokinetic behavior of Puerarin. Samples of blood and brain were collected by microdialysis and determined by high-performance liquid chromatography–mass spectrometry (MS)/MS. Pharmacokinetic parameters were estimated from the concentration versus time data using non-compartmental methods. In addition, a comparative pharmacokinetic study of Puerarin in stroke rats was studied after administration of the Radix Puerariae Extract via different routes to find an effective way to deliver drug into brain. Obvious pharmacokinetic differences were also observed in comparison between the Puerarin group and the Radix Puerariae Extract group based on middle cerebral artery occlusion (MCAO) rats. The Cmax and area under the curve (AUC) of Puerarin in olfactory bulb of the Extract group significantly reduced when it was intravenously administered. However, the AUCs of Puerarin in plasma are 134.72 and 1707.02 mg/L min, via intranasal and intravenous administration of the Radix Puerariae Extract, respectively. The AUC of the intranasal group in brain is seven times higher than that of intravenous administration. Other ingredients in the Extract may affect the disposition of Puerarin and its transportation through the blood–brain barrier via intravenous administration. But intranasal administration is an effective route to deliver isoflavone-C-glycoside with poor hydrophilicity into brain.
Insights into Endothelin-3 and Multiple Sclerosis
Authors: Monti Lucia , Arrigucci Umberto , Rossi Alessandro 
Published: July 2020

AbstractEndothelins are powerful vasoconstrictor peptides that play numerous other roles. Endothelin-1 (ET1) is the principal isoform produced by the endothelium in the human cardiovascular system. Endothelin-3 (ET3) and its rPptor affinity have been demonstrated to support neuronal repair mechanisms throughout life. In multiple sclerosis (MS), the role of vasoactive peptides are not well defined. Here we focus on ET3, specifically the plasma levels between MS patients and healthy subjects. Furthermore, we evaluated the changes in ET1 and ET3 plasma levels during different disease phases, the correlation between ET3 and cerebral circulation time, and the relationship between ET1 and ET3. In MS patients, the ET3 plasma levels were altered in a time-dependent manner. These results could support a putative role of ET3 in neuroprotection and/or neuroimmune modulation over time.
Genotype/phenotype relationship in Gaucher disease patients. Novel mutation in glucocerebrosidase gene
Authors: Lepe-Balsalobre Esperanza , Santotoribio José D. , Nuñez-Vazquez Ramiro , García-Morillo Salvador , Jiménez-Arriscado Pilar , Hernández-Arévalo Paula , Delarosa-Rodríguez Rocío , Guerrero Juan M. , Macher Hada C. 
Published: July 2020

Abstract

Objectives
Gaucher disease (GD) is the most common inherited lysosomal storage disease, caused by mutations in acid β-glucosidase (GBA) gene. This study aimed to identify mutations in Andalusia patients with GD and their genotype-phenotype correlation.

Methods
Descriptive observational study. University Hospital Virgen del Rocio patients diagnosed from GD from 1999 to 2019 were included. Demographic and clinical data, β-glucocerebrosidase activity, variants pathogenic in GBA gene and biomarkers for monitoring treatment were collected from digital medical record.

Results
Twenty-six patients with aged between 1 day and 52 years were studied. A total of six mutations described as pathogenic and one mutation not described above [c.937T>C (p.Tyr313His)] were identified in the GBA gene, four patients were homozygotes and 22 compound heterozygotes. Twenty-four patients were diagnosed in non-neuropathic form (type 1) and two cases presented neurological involvement (type 2 or 3). The most common variant was c.1226A>G (p.Asn409Ser), which was detected in 24 patients, followed by c.1448T>C (p.Leu483Pro) variant, identified in 13 patients. The c.1448T>C (p.Leu483Pro) mutation has been presented in the most severe phenotypes with neurological involvement associated with type 2 and 3 GD, while c.1226A>G (p.Asn409Ser) mutation has not been associated with neurological alterations. Splenomegaly and bone disease were the most frequent clinical manifestations, and thrombocytopenia was the most common hematological disorder.

Conclusions
The c.1226A>G (p.Asn409Ser) and c.1448T>C (p.Leu483Pro) mutations were the most common. The c.937T>C (p.Tyr313His) was identified as a novel mutation. The c.1448T>C (p.Leu483Pro) mutation was associated with neurological alterations and c.1226A>G (p.Asn409Ser) mutation has not been associated it.
Characterization of soil water by the means of hydrogen and oxygen isotope ratio at dry-wet season under different soil layers in the dry-hot valley of Jinsha River
Authors: Xu Duan , Jiao-Jiao Han , Yang-Yi Zhao 
Published: July 2020

AbstractThe soil water was stratified sampling and analyzed with 0–100 cm by three plantation (Leucaena Benth Forest land, Dodonaea angustifolia Shrub land and Heteropogon contortus grassland) at the dry-hot Valley in Jinsha River, at June, September, December of 2016, which were to know about the variation and mechanism of soil water movement. The results showed that (1) soil water in different soil layers is significantly different, and the overall performance is shrub land (11.65%) > grassland (8.29%) > forest land (6.76%); (2) the δD isotope ratio of the soil water from all samples ranged from −146.359% to −54.628% and the δ18O isotope ratio ranged from −20.272% to −2.148%, and there is a good linear relationship between isotope ratios of soil water of three different soils; (3) there is a change with season: the intercept of the isotopes ratio at different months decreased in turn, June < September < December. While the shrub lands and grassland had the same pattern but slightly different, the isotope ratio of soil moisture in December was lower, and the intercepts of shrub land in September were significantly larger than in December; (4) there is a change in space: the total difference isotopes ratio of soil water is larger at the shallow soil layer and changed sharply at all positions of the forestland, while those in the shrub land and grassland changed became relatively weakly. This study provides the theoretical basis for the key problems of plant water using mechanism, ecological water demand, vegetation recovery and so on.
Viewing Latina Immigrant Mothers in Asturias, Spain, Through an Existential Psychology Lens
Authors: Berrocal Elizabeth 
Published: July 2020

Abstract
This paper reports the results of using an existential psychology perspective to examine interview responses of 13 Latina mothers who had immigrated to the Asturias region of Spain. Purposes of the interviews included determining the Latinas’ reasons for immigrating. their post-migration challenges, and their responses to those challenges. Thematic analysis of the Latinas’ answers to interview questions revealed that their deciding to migrate to Spain and their responses to post-migration challenges can be understood in terms of the key existential psychology concepts of free choice and meaning. The analysis revealed two self-identifications that provided the Latinas with life meaning that helped them deal with challenges: Being a Mother and Determination to Move Forward. It is argued that the presence of these two meanings in the Latinas’ experiences provided them with a sense of coherence, purpose, and significance and helps account for the women’s strength and resilience in the face of post-immigration economic, social, and personal challenges and for their choosing to remain in Spain despite those challenges.