bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supply chain coordination under nonlinear cap and trade carbon emission function and demand uncertainty
Authors: Heydari Jafar , Mirzajani Zahra 
Published: February 2020

Purpose
This paper investigates to find whether it is possible to align the interests of a small and medium manufacturing enterprise (SMME) with its raw material supplier in a manufacturing supply chain (MSC) to achieve a sustainable solution. To this end, current study examines the coordination of an MSC under cap and trade consisting of a raw material supplier and a carbon-emitting SMME confronting a stochastic demand.

Design/methodology/approach
The model is developed under both the decentralized and centralized decision-making scenarios. Under the investigated model, the SMME decides on both production quantity and sustainability level simultaneously. To achieve coordination and align the interests of both MSC members toward sustainable economic development goals, a customized revenue-sharing contract is developed.

Findings
Although the centralized model is profitable for the MSC, it makes a loss for the SMME compared to the decentralized scenario. The revenue-sharing agreement is able to create coordination among the MSC members and optimize profitability and sustainability. The established revenue-sharing guarantees a Pareto-improving situation for both members. Applying the established contract not only reduces shortage occasions but also results in more sustainability levels, which in turn means movement toward attaining sustainable economic development goals.

Originality/value
Unlike previous studies, carbon emission is assumed as a nonlinear decreasing function of the sustainability level which is a more realistic case. In accordance with SMMEs business environments, the market demand is also assumed uncertain. In addition, instead of assuming an investment cost for sustainability, the authors assumed unit production/purchasing costs as functions of product sustainability level.
Framing a promotional offer as free-with-purchase or as a bundle? The perspective of information salience
Authors: Ku Hsuan-Hsuan , Wang Szu-Han , Chiang Hao-Wei 
Published: February 2020

PurposeBased on the concept of information salience, the research investigates the factors that might drive potential differences in consumers' preferences between offers framed as free with purchase or as a bundle.Design/methodology/approachFour experiments examined how participants' preferences for bundled offers or free-with-purchase offers varied as a function of the perceived benefits to be obtained from the supplementary products (studies 1a and 1b) and identified participants' sensitivity to the price of the supplementary component as a mediator of the framing effect of a promotional offer (study 2) and the provision of information facilitating the drawing of comparisons as the boundary condition constraining the effectiveness of a free-with-purchase offer (study 3).FindingsResults show that a bundled offer is preferable to a free-with-purchase offer when the supplementary product provides a high-level rather than a low-level benefit and identify price sensitivity as an underlying mechanism behind the observed effect. Furthermore, consumers' sensitivity to the value of the focal product in the deal brought to their attention by comparative information makes a fair charge for a relatively unattractive component the preferable offer.Originality/valueWhile much of the existing published research on bundled offers focuses on the assigning of discounts to individual products in the bundle, this study adds to the body of knowledge by showing that variation in perceived benefits is the key driver of different responses to a free-with-purchase offer versus a bundled offer.
The fourth industrial revolution: a game-changer for the tourism and maritime industries
Authors: Armoo A. Kobina , Franklyn-Green Lanna-Gaye , Braham Atneil J. 
Published: February 2020

Purpose
This paper aims to examine the floating dry dock and 3D printing technologies in relation to the ways in which they have the potential to complement each other. This relates to how the tourism and maritime industries in Jamaica could become more robust and competitive.

Design/methodology/approach
This study used a qualitative approach through the application of personal interviews and data from secondary sources.

Findings
Although Jamaica is positioning itself to become one of the leading maritime and logistics centres in the world, the government has not fully taken advantage of the fourth industrial revolution and its enabling factors. The integration of the floating dry dock with 3D printing technology has the ability to advance Jamaica from its current position to become a more economically viable country.

Research limitations/implications
Time was a limitation for the researchers in conducting this study. As a result, a more robust field study is needed to fully understand the impact of the fourth industrial revolution technologies on the maritime and tourism industries.

Practical implications
An investment in a floating dry dock and 3D printing technology will spur job creation. The researchers expect improved economic activity in Jamaica resulting from many businesses being created and/or improved.

Social implications
The quality of life is expected to increase because of the greater economic yields the country will receive from such investments.

Originality/value
This paper explored the combination of the floating dry dock and 3D printing technologies and their impact on the tourism and maritime industries in relation to increasing service value and economic yields.
Accounting for flow intermittency in environmental flows design
Authors: Acuña Vicenç , Jorda‐Capdevila Dídac , Vezza Paolo , De Girolamo Anna Maria , McClain Michael E. , Stubbington Rachel , Pastor Amandine V. , Lamouroux Nicolas , von Schiller Daniel , Munné Antoni , Datry Thibault 
Published: February 2020

AbstractRiver ecosystems world‐wide are affected by altered flow regimes, and advanced science and practice of environmental flows have been developed to understand and reduce these impacts. But most environmental flows approaches ignore flow intermittency, which is a natural feature of 30% of the global river network length. Ignoring flow intermittency when setting environmental flows in naturally intermittent rivers might lead to deleterious ecological effects.We review evidence of the ecological effects of flow intermittency and provide guidance to incorporate intermittency (non‐flow events) into existing methods judged as suitable for application in temporary waterways.To better integrate non‐flow events into hydrological methods, we propose a suite of new indicators to be used in the range of variability approach. These indicators reflect dry periods and the unpredictable nature of temporary waterways. We develop a predictability index for protecting those species adapted to temporary conditions.For hydraulic‐habitat models, we find that mesohabitat methods are particularly effective for describing complex habitat dynamics during dry phases. We present an example of the European eel to show the relationship between discharge and non‐flow days and wet area, habitat suitability and connectivity.We find that existing holistic approaches may be applied to temporary waterways without significant structural alteration to their stepwise frameworks, but new component methods are needed to address flow‐related aspects across both flow and non‐flow periods of the flow regime.Synthesis and applications. Setting environmental flow requirements for temporary waterways requires modification and enhancement of existing approaches and methodologies, most notably the explicit consideration of non‐flow events and greater integration of specific geomorphic, hydrogeologic and hydraulic elements. Temporary waterways are among the freshwater ecosystems most vulnerable to alterations in flow regimes, and they are also under great pressure. The methodological modifications recommended in this paper will aid water managers in protecting key components of temporary flow regimes, thereby preserving their unique ecology and associated services.
The community‐level scaling relationship between leaf nitrogen and phosphorus changes with plant growth, climate and nutrient limitation
Authors: Guo Yanpei , Yan Zhengbing , Gheyret Gheyur , Zhou Guoyi , Xie Zongqiang , Tang Zhiyao 
Published: February 2020

Abstract

The scaling relationship between the concentrations of leaf nitrogen (N) and phosphorus (P), which can be formulated as [N] = α[P]β, shows the relative investment of plants in nutrient uptake. Most of the current knowledge on this topic is based on studies at the individual or species level. However, patterns at these levels can hardly reflect the response of vegetation or ecosystems along environmental gradients.

Here, we explored how the nutrient demands of vegetation as a whole vary with productivity, climate and soil nutrient availability by generalizing the scaling relationship from the individual to the community level using community‐weighted mean data from shrub communities at 1,080 shrubland sites and tree communities at 2,087 forest sites across China.

By comparing the community‐level leaf N–P scaling exponents under different conditions and using a bootstrapping method to construct continuous environmental gradients, we found that the scaling exponents declined with increased primary productivity (i.e. growth rate at the community level), temperature and water availability, indicating a higher P demand relative to N under these conditions. In addition, the scaling exponent of shrub communities had a declining trend, while that of tree communities had a rising trend, with higher soil N availability, showing a more resistant response of shrub communities to nutrient limitation.

Synthesis. Our study demonstrates that leaf N–P scaling exponents could be used as indicators of plant growth conditions and, more importantly, that communities, as assemblages of plants, exhibits varied nutrient preferences and utilization strategies among different habitat conditions.
MUC15 promotes growth and invasion of glioma cells by activating Raf/MEK/ERK pathway
Authors: Cheng Meixiong , Liu Ling 
Published: February 2020

AbstractMUC15 is a novel mucin associated with the cell membrane that is overexpressed in human gliomas. Its function in glioma is unclear. In this study, high MUC15 levels were detected in glioma tissues and cells. We found that transfection with MUC15 siRNA in U251 and T98G cells reduced MUC15 expression and decreased cell proliferation, invasion, and migration (P < .05). After transfecting U251 and T98G cells with pcDNA3.1‐myc‐His‐MUC15 plasmid to overexpress MUC15, MUC15 expression was significantly upregulated and cell proliferation, invasion, and migration were increased (P < .05). MUC15 activated the Raf/MEK/ERK signalling pathway and the ERK inhibitor PD98059 partly reversed MUC15‐enhanced proliferation, invasion, and migration of glioma cells (P < .05). The results indicate that MUC15 plays a part in glioma tumorigenesis, and the Raf/MEK/ERK signalling is involved in the regulation of MUC15 on glioma cell activity.
Second‐look endoscopy‐guided therapy under sedation prevents early rebleeding after variceal ligation for acute variceal bleeding
Authors: Wang An Jiang , Wang Jian , Zheng Xue Lian , Liao Wang Di , Yu Hui Qiang , Gong Yue , Gan Na , You Yu , Guo Gui Hai , Xie Bu Shan , Zhong Jia Wei , Hong Jun Bo , Liu Li , Shu Xu , Zhu Yin , Li Bi Min , Zhu Xuan 
Published: February 2020

ObjectivesTo investigate whether second‐look endoscopy (SLE)‐guided therapy could be used to prevent post‐endoscopic variceal ligation (EVL) early bleeding.MethodsConsecutive cirrhotic patients with large esophageal varices (EV) receiving successful EVL for acute variceal bleeding (AVB) or secondary prophylaxis were enrolled. The patients were randomized into a SLE group and a non‐SLE group (NSLE) 10 days after EVL. Additional endoscopic interventions as well as proton pump inhibitors and octreotide administration were applied based on the SLE findings. The post‐EVL early rebleeding and mortality rates were compared between the two groups.ResultsA total of 252 patients were included in the final analysis. Post‐EVL early rebleeding (13.5% vs 4.8%, P = 0.016) and bleeding‐caused mortality (4.8% vs 0%, P = 0.013) were more frequently observed in the NSLE group than in the SLE group. However, post‐EVL early rebleeding and mortality rates were reduced by SLE in patients receiving EVL for AVB only but not in those receiving secondary prophylaxis. Patients with Child‐Pugh classification B to C at randomization (hazard ratio [HR] 8.77, P = 0.034), AVB at index EVL (HR 3.62, P = 0.003), discontinuation of non‐selective β‐blocker after randomization (HR 4.68, P = 0.001) and non‐SLE (HR 2.63, P = 0.046) were more likely to have post‐EVL early rebleeding. No serious adverse events occurred during SLE.ConclusionSLE‐guided therapy reduces post‐EVL early rebleeding and mortality rates in cirrhotic patients with large EV receiving EVL for AVB.
ML‐morph: A fast, accurate and general approach for automated detection and landmarking of biological structures in images
Authors: Porto Arthur , Voje Kjetil L. 
Published: February 2020

Abstract

Morphometrics has become an indispensable component of the statistical analysis of size and shape variation in biological structures. Morphometric data have traditionally been gathered through low‐throughput manual landmark annotation, which represents a significant bottleneck for morphometric‐based phenomics. Here we propose a machine‐learning‐based high‐throughput pipeline to collect high‐dimensional morphometric data in two‐dimensional images of semi‐rigid biological structures.

The proposed framework has four main strengths. First, it allows for dense phenotyping with minimal impact on specimens. Second, it presents landmarking accuracy comparable to manual annotators, when applied to standardized datasets. Third, it performs data collection at speeds several orders of magnitude higher than manual annotators. And finally, it is of general applicability (i.e. not tied to a specific study system).

State‐of‐the‐art validation procedures show that the method achieves low error levels when applied to three morphometric datasets of increasing complexity, with error varying from 0.57% to 2.2% of the structure's length in the automated placement of landmarks. As a benchmark for the speed of the entire automated landmarking pipeline, our framework places 23 landmarks on 13,686 objects (zooids) detected in 1,684 pictures of fossil bryozoans in 3.12 min using a personal computer.

The proposed machine‐learning‐based phenotyping pipeline can greatly increase the scale, reproducibility and speed of data collection within biological research. To aid the use of the framework, we have developed a file conversion algorithm that can be used to leverage current morphometric datasets for automation, allowing the entire procedure, from model training all the way to prediction, to be performed in a matter of hours.
Improving the Validity of the Behavioral Risk Factor Surveillance System Alcohol Measures
Authors: Subbaraman Meenakshi S. , Ye Yu , Martinez Priscilla , Mulia Nina , Kerr William C. 
Published: February 2020

BackgroundValid measurement of alcohol use can be difficult in surveys, which are subject to biases like underreporting and differential nonresponse. Still, monitoring trends, policy impacts, disparities, and related issues all require valid individual‐ and state‐level drinking data collected over time. Here, we propose a double‐adjustment approach for improving the validity of the Behavioral Risk Factor Surveillance System (BRFSS) alcohol measures.MethodsValidity analyses of the 1999 to 2016 BRFSS, a general population survey of U.S. adults. Measures are aggregated to state level for N = 918 observations, single‐adjusted for BRFSS methodologic changes, and double‐adjusted by per capita consumption. Fixed‐effects models: (i) assess predictive validity using adjusted BRFSS drink volume to predict mortality outcomes and (ii) assess outcome validity using state‐level alcohol taxes to predict adjusted BRFSS volume.ResultsNeither the raw nor the single‐adjusted BRFSS drinking measures were related to mortality in the expected direction, while double‐adjusted BRFSS volume and 5+ days were significantly positively related to mortality, as expected. Spirits and beer taxes were not related to single‐adjusted BRFSS drinking in the expected direction. However, spirits and beer taxes were both significantly related to double‐adjusted BRFSS volume in the expected directions.ConclusionsFuture studies should consider using the double‐adjusted BRFSS measures to ensure the validity of drinking survey data in analyses where variation over time is considered.
Double dissociation of inhibitory effects between the hippocampal TET1 and TET3 in the acquisition of morphine self‐administration in rats
Authors: Jiang Feng‐Ze , Zheng Wei , Wu Chao , Li Yonghui , Shen Fang , Liang Jing , Li Ming , Zhang Jian‐Jun , Sui Nan 
Published: February 2020

AbstractThe development of opioid addiction involves DNA methylation. Accordingly, the DNA demethylation, induced by ten‐eleven translocation (Tet) enzymes, may represent a novel approach to prevent opioid addiction. The present study examined the role of TET1 and TET3 in the development of morphine‐seeking behavior in rats. We showed that 1 day of morphine self‐administration (SA) training upregulated TET3 but not TET1 expression in the hippocampal CA1. With 7 days of morphine SA training, the expression of TET3 in the CA1 returned to the baseline level, while the TET1 expression was downregulated. No change of TET1 and TET3 in the nucleus accumbens shell was observed in morphine SA trained rats, or in the yoked morphine rats, or in rats trained for saccharin SA. Furthermore, we found that knocking down TET3 expression in the CA1 accelerated the acquisition of morphine SA, while overexpression of the catalytic domain of TET1 in the CA1 attenuated the acquisition. Together, these findings suggest that TET1 and TET3 in the CA1 are important epigenetic modulators involved in the morphine‐seeking behavior and provide a new strategy in the treatment of opioid addiction.
Generic revision of the Chiromyzinae soldier flies of Australia (Diptera: Stratiomyidae), including the first record of Boreoides Hardy, 1920, from New Zealand
Authors: Lessard Bryan D , Yeates David K , Woodley Norman E 
Published: February 2020

AbstractWe review the generic limits and classification of the little studied Australian fauna of the soldier fly subfamily Chiromyzinae. Among chiromyzines are many species that are confirmed agricultural pests of sugar cane, maize and grasses, including Inopus rubriceps (Macquart, 1847) that has been introduced in New Zealand and the United States. A taxonomic treatment is provided for the genera that occur in Australia, including illustrations and the first robust identification key. Several nomenclatural changes are made. The monotypic genera Archimyza Enderlein, 1921, and Stenimas Enderlein, 1921, are synonymised under Chiromyza Wiedemann, 1820, and the status of four species is revised: Inopus grandicornis (Hardy, 1920a) comb. nov. and Inopus longicornis (Hardy, 1924) comb. nov. are transferred from their previous position in Chiromyza; and Chiromyza australis (Macquart, 1850) stat. rev. and Chiromyza matruelis (Enderlein, 1921) stat. rev. are transferred from their previous position in Hylorops Enderlein, 1921, rendering Hylorops a monotypic genus, endemic to Chile. A total of 13 genera are now recognised in the Chiromyzinae, with four genera and 18 described species known from Australia. We also present the first record for New Zealand of the Australian species Boreoides tasmaniensis Bezzi, 1922, which was most likely accidentally introduced.
Incidental gallbladder cancer after laparoscopic cholecystectomy: incidence, management, and prognosis
Authors: Wu Xin , Li Binglu , Zheng Chaoji , Liu Wei , Hong Tao , He Xiaodong 
Published: February 2020

AbstractAimsAlthough incidental gallbladder cancer (IGBC) diagnosed after laparoscopic cholecystectomy (LC) is not rare, its incidence, management, and prognosis are still unclear and controversial. The present study aimed to increase the understanding of IGBC after LC in the medical community.MethodsPatients with IGBC treated at our institution between January 2001 and December 2018 were enrolled. Data collected included demographic characteristics, treatment pattern, pathological information, and prognoses. We compared the characteristics of patients with different prognoses and calculated the cumulative overall survival rate and mean survival period for IGBC.ResultsThe cohort comprised 26 patients with a mean age of 66.4 ± 12.5 years. All patients were diagnosed with IGBC via postoperative pathology. Three patients underwent radical reoperation. As of June 2019, 26 patients were followed for a mean of 31.6 ± 29.6 months. Fourteen patients died during the follow‐up period, and 12 survived without recurrence. The mean survival duration was 50.5 months. The 1‐, 3‐, and 5‐year cumulative overall survival rates of the entire cohort were 79.8, 49.0, and 40.8%, respectively. IGBC patients with T1a stage had significantly longer survival than those with T1b or more advanced stages (96.1 vs 32.6 months, P = .006).ConclusionsIGBC after LC is diagnosed in 0.2% of patients, accounting for 5.4% of all gallbladder cancer cases. IGBC patients with T1a stage had significantly longer survival than those with T1b or more advanced stages. Simple cholecystectomy is probably acceptable only in T1a lesions.
Artemisia annua‐sublingual immunotherapy for seasonal allergic rhinitis: A randomized controlled trial
Authors: Lou Hongfei , Huang Yanran , Ouyang Yuhui , Zhang Yuan , Xi Lin , Chu Xiaohan , Wang Yang , Wang Chengshuo , Zhang Luo 
Published: February 2020

AbstractBackgroundArtemisia annua is an important autumnal pollen allergen for seasonal allergic rhinitis (SAR) in northern China. To date, no study has investigated allergen immunotherapy with A annua. We aimed to investigate the efficacy and mechanisms underlying A annua‐sublingual immunotherapy (SLIT).MethodsThis was a randomized, double‐blind, placebo‐controlled phase III clinical trial involving 71 SAR patients, randomized to SLIT with A annua extract (n = 47) or placebo (n = 24) for 32 weeks. Total nasal symptom score (TNSS; primary clinical end point) was evaluated at baseline (peak pollen phase (PPP) in the previous year), initiation of A annua‐SLIT, 1st PPP during SLIT, end of SLIT and 2nd PPP during follow‐up. Blood samples and nasal secretions were collected at beginning and after SLIT for assessment of T cells and inflammatory mediators. Safety was assessed according to adverse events (AEs) reported.ResultsArtemisia annua‐SLIT significantly reduced TNSS to a greater level from baseline (from 9.45 ± 1.68 to 6.16 ± 2.27) than placebo (from 9.29 ± 2.09 to 9.05 ± 2.40) at the 1st PPP (P < .001) and sustained the improvement in symptoms throughout to the 2nd PPP. Preseasonal A annua‐SLIT for 16 weeks significantly decreased Th2 cells, increased nTreg and Tr1 cells in blood; and increased cystatin 1 (CST1) in nasal secretion after 16 and 32 weeks compared with pretreatment. Overall, 17/47 patients experienced mild local AEs and 2 patients mild systemic AEs, after A annua‐SLIT.ConclusionArtemisia annua‐SLIT is an efficacious and safe treatment in patients with A annua SAR.