bluuebunny/crossref_metadata_2025_split huggingface dataset:
Virtual simulation with Sim&Size software for Pipeline Flex Embolization: evaluation of the technical and clinical impact
Authors: Piergallini Lorenzo , Cagnazzo Federico , Conte Giorgio , Dargazanli Cyril , Derraz Imad , Lefevre Pierre-Henri , Gascou Gregory , Mantilla Daniel , Riquelme Carlos , Bonafe Alain , Costalat Vincent 
Published: February 2020

IntroductionDuring flow diversion, the choice of the length, diameter, and location of the deployed stent are critical for the success of the procedure. Sim&Size software, based on the three-dimensional rotational angiography (3D-RA) acquisition, simulates the release of the stent, suggesting optimal sizing, and displaying the degree of the wall apposition.ObjectiveTo demonstrate technical and clinical impacts of the Sim&Size simulation during treatment with the Pipeline Flex Embolization Device.MethodsConsecutive patients who underwent aneurysm embolization with Pipeline at our department were retrospectively enrolled (January 2015–December 2017) and divided into two groups: treated with and without simulation. Through univariate and multivariate models, we evaluated: (1) rate of corrective intervention for non-optimal stent placement, (2) duration of intervention, (3) radiation dose, and (4) stent length.Results189 patients, 95 (50.2%) without and 94 (49.7%) with software assistance were analyzed. Age, sex, comorbidities, aneurysm characteristics, and operator’s experience were comparable among the two groups. Procedures performed with the software had a lower rate of corrective intervention (9% vs 20%, p=0.036), a shorter intervention duration (46 min vs 52 min, p=0.002), a lower median radiation dose (1150 mGy vs 1558 mGy, p<0.001), and a shorter stent length (14 mm vs 16 mm, p<0.001).ConclusionsIn our experience, the use of the virtual simulation during Pipeline treatment significantly reduced the need for corrective intervention, the procedural time, the radiation dose, and the length of the stent.
Shuxuetong for Prevention of recurrence in Acute Cerebrovascular events with Embolism (SPACE) trial: rationale and design
Authors: Gu Hong-Qiu , Xie Xue-Wei , Jing Jing , Meng Xia , Lv Wei , Yu Jian-Dong , Lv Xiang-Ping , Li Hao , Wang Yi-Long , Wang Yong-Jun 
Published: February 2020

Backgrounds
Embolic stroke is one of the main mechanisms of ischaemic stroke. Even if treated with recommended antithrombotic agents, stroke recurrence remains high. The Shuxuetong injection, a purified extract of traditional Chinese medicine widely used for thrombus diseases in clinical practice in China, could be a promising agent to prevent stroke recurrence.

Aims
To describe the design of the Shuxuetong injection for prevention of recurrence in acute ischaemic stroke with embolism mechanisms.

Design
The Shuxuetong for Prevention of recurrence in Acute Cerebrovascular events with Embolism (SPACE) trial is a multicentre, randomised, double-blind, placebo-controlled, parallel-group, superiority trial to evaluate the efficacy and safety of Shuxuetong injection in reducing recurrence or silent new ischaemic lesions on patients with acute embolic stroke within 10 days. An estimated 2416 patients with embolic stroke within 72 hours of symptom onset from 80 hospitals will be randomly assigned to one of two groups receiving Shuxuetong injection or placebo injection for 10 days. The primary endpoint is symptomatic or asymptomatic new cerebral infarction within 10 days after randomisation.

Conclusion
The SPACE Trial will provide valuable evidence for the efficacy and safety of Shuxuetong injection for the prevention of stroke recurrence in patients with imaging-defined embolic stroke.

Clinical trial registration

NCT03090113
.
Revision of the Azorean catalogue of tsunamis
Authors: Cabral N. 
Published: February 2020

Abstract
The Azores islands, owing to their complex geographical and geodynamic setting, are exposed to tsunami events associated with different triggering mechanisms, local or distant. Since the settlement of the Azores, in the fifteenth century, there have been numerous accounts that relate coastal area flooding episodes with unusually high waves that caused death and destruction. In this work is presented a review and a characterization of the different events registered in the archipelago that can be associated with tsunamigenic phenomena. For this purpose, diverse documentation was collected such as chronics, manuscripts, newspaper articles and magazines, scientific publications and international databases available online. Thus, new relevant information allowed better characterization of some events. Furthermore, it was possible to add new entries and to discard others included in previous compilations owing to a lack of quality in historical sources or instrumental records. Some teletsunamis, among them the 1 November 1755 which killed six people on Terceira Island, regional and local tsunamis were identified. Although the majority of these events result from tectonic sources, some were also triggered by landslides, such as the 9 July 1847 Quebrada Nova tsunami which killed 10 people on Flores and Corvo islands, and by meteorological phenomena.
Distinct hemodynamic responses to (pyr)apelin-13 in large animal models
Authors: Tune Johnathan D. , Baker Hana E. , Berwick Zachary , Moberly Steven P. , Casalini Eli D. , Noblet Jillian N. , Zhen Eugene , Kowala Mark C. , Christe Michael E. , Goodwill Adam G. 
Published: February 2020

This study tested the hypothesis that (pyr)apelin-13 dose-dependently augments myocardial contractility and coronary blood flow, irrespective of changes in systemic hemodynamics. Acute effects of intravenous (pyr)apelin-13 administration (10 to 1,000 nM) on blood pressure, heart rate, left ventricular pressure and volume, and coronary parameters were measured in dogs and pigs. Administration of (pyr)apelin-13 did not influence blood pressure ( P = 0.59), dP/d tmax ( P = 0.26), or dP/d tmin ( P = 0.85) in dogs. However, heart rate dose-dependently increased > 70% ( P < 0.01), which was accompanied by a significant increase in coronary blood flow ( P < 0.05) and reductions in left ventricular end-diastolic volume and stroke volume ( P < 0.001). In contrast, (pyr)apelin-13 did not significantly affect hemodynamics, coronary blood flow, or indexes of contractile function in pigs. Furthermore, swine studies found no effect of intracoronary (pyr)apelin-13 administration on coronary blood flow ( P = 0.83) or vasorelaxation in isolated, endothelium-intact ( P = 0.89) or denuded ( P = 0.38) coronary artery rings. Examination of all data across (pyr)apelin-13 concentrations revealed an exponential increase in cardiac output as peripheral resistance decreased across pigs and dogs ( P < 0.001; R2 = 0.78). Assessment of the Frank-Starling relationship demonstrated a significant linear relationship between left ventricular end-diastolic volume and stroke volume across species ( P < 0.001; R2 = 0.70). Taken together, these findings demonstrate that (pyr)apelin-13 does not directly influence myocardial contractility or coronary blood flow in either dogs or pigs. NEW & NOTEWORTHY Our findings provide much needed insight regarding the pharmacological cardiac and coronary effects of (pyr)apelin-13 in larger animal preparations. In particular, data highlight distinct hemodynamic responses of apelin across species, which are independent of any direct effect on myocardial contractility or perfusion.
A Promising Innovative Treatment for ST-Elevation Myocardial Infarction: The Use of C-Reactive Protein Selective Apheresis: Case Report
Authors: Boljevic Darko , Nikolic Aleksandra , Rusovic Sinisa , Lakcevic Jovana , Bojic Milovan , Balint Bela 
Published: February 2020

<b><i>Background:</i></b> In patients with ST-elevation myocardial infarction (STEMI), C-reactive protein (CRP) levels are associated with larger infarct size, transmural extent, and poor function of left ventricle and independently predict 30-day mortality. CRP-apheresis following STEMI showed to be feasible, safe, and has significant beneficial effect both on myocardial infarction size and wall motion. To the best of our knowledge, this is only the second published clinical evaluation of the efficacy and safety of selective CRP-apheresis in the STEMI treatment using Spectra-Optia and Pentrasorb CRP-adsorber systems. <b><i>Case Report:</i></b> A 53-year-old female was referred with anterior STEMI. After percutaneous coronary intervention, patient received standard post-STEMI therapy according to current guidelines. Selective therapeutic plasma exchange (TPE) was performed using Spectra-Optia (Terumo BCT; USA) and Pentrasorb CRP-adsorber (Pentracor GmbH; Germany) systems. Antecubital veins were used for vascular access and acid-citrate-dextrose solution (ACD formula A; total volume = 1,026 mL) was utilized as anticoagulant. The volume of processed blood was 15,600 mL. The removed “natural” plasma (total volume = 8,329 mL) was replaced with CRP-depleted autologous plasma (total volume = 8,085 mL). This intensive TPE-treatment was well tolerated, without adverse effects, or complications. The CRP plasma levels were: initial = 4.2 mg/L 6 h after acute myocardial infarction (AMI), pre-apheresis = 16.4 mg/L, and post-apheresis = 4.59 mg/L (CRP-depletion = 72%). There were neither significant changes observed in biochemistry nor any alterations in plasma hemostatic activity investigated before and after CRP-adsorption performed. <b><i>Conclusion:</i></b> Early performed CRP-apheresis is a promising innovative therapeutic approach for STEMI treatment that could provide a reduced size of infarction zone – with inferior occurrence of heart failure after AMI. However, precise and complete evaluation of the efficacy and safety of this treatment requires further multicenter randomized and larger clinical studies.
Mixed Valvular Disease Following Transcatheter Aortic Valve Replacement: Quantification and Systematic Differentiation Using Clinical Measurements and Image‐Based Patient‐Specific In Silico Modeling
Authors: Keshavarz‐Motamed Zahra , Khodaei Seyedvahid , Rikhtegar Nezami Farhad , Amrute Junedh M. , Lee Suk Joon , Brown Jonathan , Ben‐Assa Eyal , Garcia Camarero Tamara , Ruano Calvo Javier , Sellers Stephanie , Blanke Philipp , Leipsic Jonathon , de la Torre Hernandez Jose M. , Edelman Elazer R. 
Published: February 2020

Background
Mixed valvular disease (MVD), mitral regurgitation (MR) from pre‐existing disease in conjunction with paravalvular leak (PVL) following transcatheter aortic valve replacement (TAVR), is one of the most important stimuli for left ventricle (LV) dysfunction, associated with cardiac mortality. Despite the prevalence of MVD, the quantitative understanding of the interplay between pre‐existing MVD, PVL, LV, and post‐TAVR recovery is meager.

Methods and Results

We quantified the effects of MVD on valvular‐ventricular hemodynamics using an image‐based patient‐specific computational framework in 72 MVD patients. Doppler pressure was reduced by TAVR (mean, 77%; N=72;
P
<0.05), but it was not always accompanied by improvements in LV workload. TAVR had no effect on LV workload in 22 patients, and LV workload post‐TAVR significantly rose in 32 other patients. TAVR reduced LV workload in only 18 patients (25%). PVL significantly alters LV flow and increases shear stress on transcatheter aortic valve leaflets. It interacts with mitral inflow and elevates shear stresses on mitral valve and is one of the main contributors in worsening of MR post‐TAVR. MR worsened in 32 patients post‐TAVR and did not improve in 18 other patients.

Conclusions

PVL limits the benefit of TAVR by increasing LV load and worsening of MR and heart failure. Post‐TAVR, most MVD patients (75% of N=72;
P
<0.05) showed no improvements or even worsening of LV workload, whereas the majority of patients with PVL, but without that pre‐existing MR condition (60% of N=48;
P
<0.05), showed improvements in LV workload. MR and its exacerbation by PVL may hinder the success of TAVR.
Waiting (and Paying) for Godot: Analyzing the Systemic Consequences of the Solidarity Crisis in EU Asylum Law
Authors: Marin Luisa 
Published: February 2020

Abstract
What is left of the principle of solidarity in the context of EU asylum law?
The aim of this article is to analyze the follow-up of the solidarity crisis the EU has experienced with the failure of relocation schemes. Relocation schemes have tried to alleviate the consequences of the so-called migration crisis of 2015–2016, but did not prove to be successful, because of the low relocation rates, in addition to open contestation by states of the Visegrad group.
Against the background of the stalemate of the reform of the Dublin Regulation, the article analyzes ‘measures’ adopted after the failure of relocation schemes, focusing in particular on administrative arrangements to counter secondary movements and ‘ad hoc’ temporary disembarkation schemes. Both measures are aiming at fixing longstanding questions (e.g., limiting secondary movements, providing safe disembarkation for irregular migrants): in the first case, States proceed at bilateral level with arrangements creating fast-track returns and stopping secondary movements; in the second case, the EU is trying to support states’ arrangements for disembarkation of migrants after SAR operations.
The article shows that, while reforms of legislative instruments are not progressing, Member States and, to some extent, also EU institutions are going down the lane of ‘operational and informal arrangements’, which are ‘bricolage solutions’ to counterbalance undesired effects of the status quo, while waiting for structural solutions that are necessary but not in sight.
The article discusses the dangers of such a trend toward informal operational solutions, as a challenge to the EU as a system of governance based on the rule of law.
History, Memory of Slavery and Research Film in Brazil
Authors: Mattos Hebe , Abreu Martha , Castro Isabel 
Published: February 2020

Abstract
This article examines the experience of making a set of four research films that collectively comprise the “Present Past” collection (http://www.labhoi.uff.br/passadospresentes/en/filmes_passados.php). The films were developed based on the oral history project “Memories of Slavery” (1995–2005) and the subsequent visual oral history project “Present Pasts” from 2005 to 2012, conducted at the Laboratory of Oral History and Image of Federal Fluminense University in Brazil (LABHOI/UFF). The article analyzes the process of creating each film, discussing the relationships between history, memory, and politics, and considering the contributions that film as a medium brings to historical research.
“We Would Ride Safely in the Harbor of the Future”: Historical Parallels between the Existential Threats of Yellow Fever and Sea Level Rise in New Orleans and Norfolk
Authors: Foster Morris W. , Steinhilber Emily E. 
Published: February 2020

AbstractThe nineteenth-century experiences of yellow fever epidemics in New Orleans and Norfolk present historical parallels for how those cities, and others, are experiencing existential threats from climate change and sea level rise in the twenty-first century. In particular, the nineteenth-century “sanitary reform” movement can be interpreted as a model for challenges facing twenty-first-century “climate resilience” initiatives, including denialism and political obfuscation of scientific debates as well as tensions between short-term profit and the cost of long-term infrastructure investments and between individualism and communitarianism. The history of sanitary reform suggests that, at least in the United States, climate resilience initiatives will advance largely on a regional basis through extended local debates around these and other challenges until resilient infrastructure and practices are taken for granted, much as sanitary waterworks and sewers are today.
Metropolitan Feminisms of Middle-Class India: Multiple Sites, Conflicted Voices
Authors: Nair Sharada 
Published: February 2020

Across Indian metropolises, large demonstrations protesting violence against women have become very frequent, marking the present as a significant moment for feminism. I use the term feminism metonymically, to signify the force activated in the name of justice, when women foreground their gender identity. This clarification is prompted by the resistance to these terms seen as Western, culturally different from the milieu here constituted by an active meld of economic and socio-political features. However, in the immense heterogeneity of the cities, markers such as region, caste, religion, etc, get marginalized, though definitely not erased. Impediments to any neat, progressive reading of the public assertions are many. Gender gets displaced when other contexts, which have produced us as women through differentiations, come into play unexpectedly. Breaking the hegemony of cultural imaginaries remains a work in process.
Are Major US Trading Partners’ Exports and Imports Cointegrated? Evidence from Bootstrap ARDL
Authors: Goh Soo Khoon , Tang Tuck Cheong , Sam Chung Yan 
Published: February 2020

A study by McNown, Sam, and Goh [2018, Applied Economics, 50(13), 1509–1521] has shown that the autoregressive distributed lag (ARDL) bounds test proposed by Pesaran, Shin, and Smith [2001, Journal of Applied Econometrics, 16(3), 289–326] may draw incorrect conclusions on the status of the cointegration test, if the ARDL bounds test is not implemented correctly. We assess the long-run relationship between US exports and imports as well as between its eight major trading partners (Brazil, Canada, China, France, Germany, Japan, Mexico, and the United Kingdom) by applying the newly developed bootstrap ARDL test by McNown et al. (2018). The results show cointegration if exports are used as the dependent variable, but not when imports are being considered as the dependent variable. This suggests that the cointegration result is sensitive to the choice of the dependent variable. We have similar findings when we examine the US and its major trading partners. No long-run relationship exists between exports and imports in the case of the US, which concurs with the finding of Fountas and Wu [1999, International Economic Journal, 13(3), 51–58]. The results also suggest that the US attempts to reduce its bilateral imbalances through targeted trade policies may not be appropriate. JEL Classification: F14, C22
Developing a Model of Video Game Play: Motivations, Satisfactions, and Continuance Intentions
Authors: Patzer Brady , Chaparro Barbara , Keebler Joseph R. 
Published: February 2020

Background. As video game usage continues to rise, it is important to understand why people choose and continue playing a game. Purpose. This research presents a theoretical framework to explore the relationships between gameplay motivations, satisfaction, continuance intention and gameplay. Methods. To examine these relationships, survey data was collected from 353 participants who played different types of online games, including League of Legends, World of Warcraft, Overwatch, and Hearthstone, for at least 10 hours in the past three months. A series of structural equation models were tested to identify the model with the best validity and fit. All constructs were from previously validated measures. Motivations were measured by the Trojan Player Typology, which assessed story-driven, completionist, competitor, escapist, smarty-pants, and socializer motives. Satisfaction was measured using the game user experience satisfaction scale (GUESS), which assessed satisfaction with usability/playability, narratives, play engrossment, enjoyment, creative freedom, audio aesthetic, personal gratification, social connectivity, and visual aesthetics. Continuance intention was measured using a 4-item scale. Results. The final model suggested that motivations were positively related to satisfaction, while satisfaction was positively related to continuance intention and weekly play time. Motivations accounted for 20% of the variance in satisfaction, and the story-driven motivation was the strongest predictor. Further, satisfaction accounted for 47% of the variance in continuance intention and 8% of the variance in weekly play time. Conclusion. Individual differences in gameplay motivation are an important component of a player’s satisfaction. Further, satisfaction appears to be central to a player’s intention to continue using a game.
The Legacy Effect in Treating Hypercholesterolemia
Authors: Kostis John B. , Shetty Mrinali , Chowdhury Yuvraj Singh , Kostis William J. 
Published: February 2020

Background: The duration of randomized controlled clinical trials usually is approximately 3 to 5 years although hypercholesterolemia and other risk factors for atherosclerotic cardiovascular disease (ASCVD) are lifelong conditions. Objectives: The legacy effect, defined as the persistence of benefit of pharmacologic interventions in clinical trials after the end of the randomized phase when all participants receive active therapy, is used to examine the long-term benefit. We summarize the evidence for the existence of the legacy effect as it pertains to hypercholesterolemia, describe underlying mechanisms, and discuss its relevance to clinical practice. Methods: We examined all published (n = 13) randomized clinical trials of lipid-lowering agents compared to placebo or usual care with follow-up after the randomized phase for the presence or absence of a legacy effect. Results: A legacy effect was demonstrated in all studies. The current US and European guidelines recommend treatment with high-intensity statins for patients with manifest ASCVD and that individualized approach be used for primary prevention. Conclusion: The legacy effect results in significant long-term clinical benefits by preventing fatal and nonfatal events. This implies that early therapy would result in lower event rates. Long-term follow-up should be a part of clinical trial design in order to evaluate the presence or absence of a legacy effect.
Ultrasound-guided tip location of midline catheters
Authors: Elli Stefano , Pittiruti Mauro , Pigozzo Valentina , Cannizzo Luigi , Giannini Luciano , Siligato Andrea , Rondelli Egle , Foti Giuseppe , Lucchini Alberto 
Published: February 2020

Introduction: Midline catheters are widely used in clinical practice. Proper placement of midline catheter tip is usually assessed only by aspirating blood and flushing with normal saline without resistance. Purpose: To describe the ultrasound-guided tip location for midline catheters and its feasibility and to compare incidence of catheter-related venous thrombosis associated with or without ultrasound tip localization. Methods: The ultrasound-guided tip location is described step by step. Feasibility of the technique and incidence of catheter-related venous thrombosis were measured (study group) and compared with two historical groups: study group, 20-cm midline catheters inserted with ultrasound-guided tip location; group 1, 25-cm midline catheters inserted without ultrasound-guided tip location and group 2, 20-cm midline catheters inserted without ultrasound-guided tip location. Results: In the study group, ultrasound-guided tip location was easily feasible in 98.9% of patients. Incidence of catheter-related venous thrombosis was 2.42% in control group 1, 9% in control group 2 and 2.62% in the study group. Discussion: In the study group and control group 1, the tip was placed in the axillary vein, about 3 cm distal to the clavicle and in the subclavian vein. In control group 2, the tip was probably located at the transition between the axillary and the subclavian vein. It is possible that such position may have been associated with an increased incidence of catheter-related venous thrombosis. Conclusion: The ideal position of the tip of a midline catheter might be inside the axillary vein, about 3 cm distal to the axillary-subclavian transition or inside the subclavian vein. Ultrasound-guided tip location is safe, inexpensive, easy and potentially useful during midline catheters insertion.