bluuebunny/crossref_metadata_2025_split huggingface dataset:
Naturally Inspired Pyrimidines Analogues for Alzheimer’s Disease
Authors: Singh Shivani , Dhanawat Meenakshi , Gupta Sumeet , Kumar Deepak , Kakkar Saloni , Nair Anroop , Verma Inderjeet , Sharma Prerna 
Published: November 2020

:Alzheimer’s disease (AD) is a multifarious and developing neurodegenerative disorder. The treatment of AD is still a challenge and availability of drug therapy on the basis of symptoms is not up to the mark. In the context of existence, which is getting worse for the human brain, it is necessary to take care of all critical measures. The disease is caused due to multidirectional pathology of the body, which demands the multi-target-directed ligand (MTDL) approach. This gives hope for new drugs for AD, summarized here in with the pyrimidine based natural product inspired molecule as a lead. The review is sufficient in providing a list of chemical ingredients of the plant to cure AD and screen them against various potential targets of AD. The synthesis of a highly functionalized scaffold in one step in a single pot without isolating the intermediate is a challenging task. In few examples, we have highlighted the importance of this kind of reaction, generally known as multi-component reaction. Multi-component is a widely accepted technique by the drug discovery people due to its high atom economy. It reduces multi-step process to a one-step process, therefore the compounds library can be made in minimum time and cost. This review has highlighted the importance of multicomponent reactions by giving the example of active scaffolds of pyrimidine/fused pyrimidines. This would bring importance to the fast as well as smart synthesis of bio-relevant molecules.
Leveraging Internet Search Data to Improve the Prediction and Prevention of Noncommunicable Diseases: Retrospective Observational Study
Authors: Xu Chenjie , Cao Zhi , Yang Hongxi , Gao Ying , Sun Li , Hou Yabing , Cao Xinxi , Jia Peng , Wang Yaogang 
Published: November 2020

Background
As human society enters an era of vast and easily accessible social media, a growing number of people are exploiting the internet to search and exchange medical information. Because internet search data could reflect population interest in particular health topics, they provide a new way of understanding health concerns regarding noncommunicable diseases (NCDs) and the role they play in their prevention.

Objective
We aimed to explore the association of internet search data for NCDs with published disease incidence and mortality rates in the United States and to grasp the health concerns toward NCDs.

Methods
We tracked NCDs by examining the correlations among the incidence rates, mortality rates, and internet searches in the United States from 2004 to 2017, and we established forecast models based on the relationship between the disease rates and internet searches.

Results
Incidence and mortality rates of 29 diseases in the United States were statistically significantly correlated with the relative search volumes (RSVs) of their search terms (P<.05). From the perspective of the goodness of fit of the multiple regression prediction models, the results were closest to 1 for diabetes mellitus, stroke, atrial fibrillation and flutter, Hodgkin lymphoma, and testicular cancer; the coefficients of determination of their linear regression models for predicting incidence were 80%, 88%, 96%, 80%, and 78%, respectively. Meanwhile, the coefficient of determination of their linear regression models for predicting mortality was 82%, 62%, 94%, 78%, and 62%, respectively.

Conclusions
An advanced understanding of search behaviors could augment traditional epidemiologic surveillance and could be used as a reference to aid in disease prediction and prevention.
PENERAPAN MODEL PEMBELAJARAN “PROJECT BASED LEARNING” PADA MATA KULIAH PEMBELAJARAN PENDIDIKAN KEWARGANEGARAAN SEKOLAH DASAR DI UNISNU JEPARA
Authors: Attalina Syailin Nichla Choirin 
Published: November 2020

This study aims to improve students learning outcomes in Civil Education Learning courses through Project Based Learning Model. The research method used is a mix method with Classroom Action Research Method and Kurt Lewin Model. The target of this research is focused on Civil Education Learning Lectures in the odd semester 2018/2019. The Research was conducted at the Elementary School Teacher Education Program, Fakulty of Teacher Training and Education, University of Islamic Nahdlatul Ulama Jepara. There are data collection techniques used in this study, namely observation, documentation and test. The data analysis techniques use descriptive statistic analysis. The result showed that the application of project based learning model can improve students learning outcomes in Civil Education Learning courses with indicator learning is learning outcomes of cognitive with increase in the percentage of learning outcomes on cognitive between cycle I and cycle II on 21% , affective on 35% and psicomotoric on 30%.
Crimean-Ottoman Factor in the Socio-Cultural System of Russia in Early Modern Times
Authors: Chernikova T. V. 
Published: November 2020

Abstract: The article gives a description of the sociocultural organization of Russia and the peculiarities of its geopolitical position in the system of international relations of the early modern period. Questions were raised about the reasons for the rapid territorial expansion of the Russian state in the second half of the 15-17 centuries, as well as its high competitiveness in foreign policy both in relations with its western neighbors and in the eastern direction.For the states of Western Europe with the beginning of their modernization, modern age has come, however “Muscovy” in the 15-17 centuries remained a medieval country. At the same time, it not only did not share the fate of many eastern powers with a traditional way, which turned into the 17th-19th centuries in the colony and semi-colony, but also, on the contrary, it led a successful colonial expansion and demonstrated externally the almost synchronous trends in state building that were inherent in the Western European countries.The author believes that the patrimonial structure of the sociocultural system of the Russian state in the 15-17 centuries contributed to the mobilization of internal material and human resources, coupled with an early superficial “Europeanization” (regular borrowing the military, technical, and cultural experience of modernizing Western Europe), ensured Russia's competitiveness in the world. Since the emergence of the united Moscow state, Russia has developed as a land empire.However, the strategic national task of Russia was not to preserve the medieval patrimony, but to create the prerequisites for its modernization. Amid the socio-economic development, which is characteristic of all countries with a patrimonial structure, that could have started only by transferring the center of Russian extensive agriculture to the southern fertile lands. This would free part of the population of the non-chernozem center for trade and industrial activities. But the transfer of the agrarian center to the south was restrained by the constant military danger from the Wild Field, which was part of the Horde, and then the Crimean Khanate, backed until the end of the 18 century by the Ottoman Empire, perceiving the Black Sea with its “inland lake”. As a result, the struggle for the Black Sea and Crimea to become a part of Russia, as well as the overcoming the patrimonial order, becomes a matter of civilizational success or failure of Russia in the context of world history.
Necesidad de música, de George Steiner
Authors: Sol Mora Pablo 
Published: November 2020

Sol Mora nos habla acerca de esta obra de George Steiner en la cual se reflexiona acerca de lo complejidad de la crítica musical. Menciona que leer a Steiner "es mucho más que leer a un crítico que a un gran conocimiento literario aúna la pasión por la música; es vérselas con alguien que parece encarnar lo mejor de la tradición occidental: la filosofía, la literatura, la música, la pintura, el arte, etc. Su vasta cultura, su plurilingüismo, su capacidad de establecer relaciones, su formación clásica, su sensibilidad moral y su agudeza lectora –que lo mismo aplica a una novela, a una sinfonía o a un cuadro– hacen de él un crítico fuera de serie y un verdadero maestro de lectura".
Philosophical and Aesthetic Reflection on the Pandemic Phenomenon
Authors: Oganov Arnold A. 
Published: November 2020

The article’s problematics is examined in the socio-cultural context. The pandemic phenomenon is considered as a metaphor derived from a pandemic of infectious diseases. The latter is nothing more than a model projected on various social evils. It is in this capacity (not in the viral-infectious one) the pandemic is used in the article. The article broadly interprets the concept of a pandemic as a universal type of general massification of a threatening nature. It is accompanied by fear, aggression, ideological delusions, economic and demographic catastrophes.Like the biomedical pandemic, its associative counterparts have been repeated with unpredictable regularity in human history. Even today, we can assume that the unforeseen consequences of information and communication technologies in the digital age bear the signs of impending pandemics. In the article, the infectious disease pandemic serves as a matrix model for characterizing an invariant version of other heterogeneous pandemics. The author builds his theoretical judgments on the material of well-known philosophical and cultural sources (L. Wittgenstein, M. Heidegger, M. Bakhtin, L. Vygotsky, S. Averintsev, R. Girard et al.), as well as on the history of art, its species and genre varieties.Particular attention is paid to the works of art whose authors intentionally give them an ambivalent meaning. A significant role is given to the subtext of the material presented, the importance of which is determined by the goal to realize the main semantic intent of the article. There is an attempt to substantiate the relevance of postmodernism culture to the modern picture of the world, to the highly ambivalent civilizational changes. The article uses the material of extensive artistic practice to trace the manifestations of postmodernism as both a symptom and a mocker of the absurdism of human existence. The final part of the article prognosticates a number of possible post-pandemic changes in various areas of public life.
MEDICAL AND PSYCHOLOGICAL STUDY OF QUALITY OF LIFE RELATED TO HEALTH IN PATIENTS OF DENTAL PROFILE
Authors: Загорко Максим Васильевич , Пантелеев Валентин Дмитриевич , Евстифеева Елена Александровна , Филиппченкова Светлана Игоревна 
Published: November 2020

Представленное междисциплинарное исследование знакомит с дискриптивным анализом качества жизни, личностным и психологическим своеобразием пациентов с патологией дисфункции височно-нижнечелюстного сустава (ВНЧС). Проведена психодиагностика их психологического статуса, включая психоэмоциональные особенности, личностные и психологические особенности в фокусе связанного со здоровьем качества жизни, а также показатели значимости болезни. Результаты исследования указывают на ухудшение связанного со здоровьем качества жизни у пациентов с ВНЧС, что объясняется повышенной тревожностью, низким уровнем психологической устойчивости, интернальности и рациональности, а также наличием средне-выраженного уровня невротизации и повышенным уровнем рефлексивности.
The presented interdisciplinary study introduces a descriptive analysis of the quality of life, personal and psychological uniqueness of patients with the pathology of temporomandibular joint dysfunction (TMJ). Psychodiagnostics of their psychological status was carried out, including psycho-emotional characteristics, personal and psychological characteristics in the focus of health-related quality of life, as well as indicators of the significance of the disease. The results of the study indicate a deterioration in the health-related quality of life in patients with TMJ, which is explained by increased anxiety, a low level of psychological stability, internality and rationality, as well as the presence of a moderate level of neurotization and an increased level of reflexivity.
SUBJECTIVE PROFESSIONAL WELL-BEING OF RAIL TRANSPORT SPECIALISTS (ON THE EXAMPLE OF MACHINISTS AND ASSISTANTS OF THE LOCOMOTIVE MACHINERY)
Authors: Акимова Анна Юрьевна , Обознов Александр Александрович , Петрович Дарья Леонидовна 
Published: November 2020

Представлены результаты изучения структуры субъективного благополучия специалистов сферы железнодорожного транспорта. Показано, что субъективное профессиональное благополучие указанных специалистов включает четыре компонента: социально-профессиональная востребованность, стремление к профессиональному развитию, доминирующее эмоциональное состояние личности, увлечённость работой/скука от работы. Каждый компонент имеет свою сложную структуру, отражающую особенности отношения специалистов железнодорожного транспорта к профессиональной деятельности, общее отношение к сложившейся жизненной ситуации и особенности профессионального менталитета. Определено, что наиболее сильные взаимосвязи наблюдаются внутри двух пар компонентов: социально-профессиональная востребованность и доминирующее эмоциональное состояние; стремление к профессиональному развитию и увлечённость работой/скука от работы.
The results of studying the structure of subjective well-being of railway specialists are presented. It is shown that the subjective professional well-being of these specialists includes four components (social and professional demand, desire for professional development, dominant emotional state, passion for work / boredom from work). Each component has its own complex structure, which reflects the peculiarities of the attitude of railway transport specialists to professional activities, the general attitude to the current life situation and the peculiarities of the professional mentality. It was determined that the strongest relationships are observed within two pairs of components: socio-professional demand and the dominant emotional state; desire for professional development and passion for work / boredom from work.
DIDACTIC BASES OF MEMORY RESOURCES ACTIVATION IN THE STUDY OF THE LINGUISTIC DISCIPLINES IN A MEDICAL UNIVERSITY
Authors: Виноградова Елена Владиславовна , Курицына Ирина Юрьевна 
Published: November 2020

Рассматривается вопрос оптимизации использования ресурсов памяти при освоении дисциплин лингвистического профиля в неязыковом вузе. На основании анализа психофизиологических закономерностей функционирования памяти обосновываются дидактические приемы, облегчающие запоминание и воспроизведение большого объема учебного материала. Приводятся примеры из практики, способствующие более полному и рациональному оперированию ресурсами памяти. Показывается, что развитие декларативной памяти и приобретение основанных на ней знаний во многом определяются способами переработки предлагаемой к усвоению учебной информации.
The article considers the problem of memory resources optimization during the linguistic courses mastery at a non-linguistic university. Based on the analysis of the psychophysiological patterns of memory functioning, didactic techniques facilitating the memorization and reproduction of a large amount of educational material are substantiated. Practical examples that contribute to a more complete and rational usage of memory resources are given. It is shown that the development of declarative memory and the acquisition of knowledge based on it are largely determined by the methods of processing the learning information proposed for assimilation.
Comparison of methods for vehicle emissions calculation and their sensitivity to fleet structuring
Authors: Maksimova O. V. , Ginzburg V. A. , Lytov V. M. 
Published: November 2020

Introduction. The study presents the results of the calculation of greenhouse gas emissions and polluting solids by vehicles fleet on the basis of three independent estimates of the set of initial data on the breakdown of the fleet by technological classes (the number and types of vehicles of different ecological classes, annual mileage, etc.). Such data is not provided in the forms of state statistical reports and is generated by the researchers. The article solves the problem of determining their significance for calculating the total emissions in the context of a large data array for the territory of Russia.Materials and methods. Three different versions to the calculation of greenhouse gas emissions (basic version, equalization of transport work and new approach - equalization of fuel consumption) are proposed in order to identify differences in the obtained emissions in different conditions (i.e., to determine quantitative characteristics of the accuracy of the final values). A new method has been developed for assessing the effect of average mileage and vehicle distribution on classes on the total emissions values, implemented within each proposed version. In addition, two types of sensitivity formulas are formed by the authors to assess the impact of vehicle distribution on classes and average mileage to final emission calculations. The use of these formulas provides scientific analysis and interpretation of the influence of the factors in expert review on the final values of the emissions of each type.Results. The differences in sorting cars into classes in expert evaluations were revealed and the closest ones are determined. It was found that the most sensitive to changes in mileage and class of cars, on which fuel consumption depends, are CO2 emissions.Conclusion. The scientific sensitivity analysis of both types showed the importance of maintaining the principles underlying expert evaluation from year to year in order to ensure that the results obtained are consistent.
Karakteristik pelajar dan social presence pada pembelajaran daring di masa pandemik covid-19
Authors: Anantyanda Luthfia Aufanzylla , Saragih Susanti Ridawaty 
Published: November 2020

This study mainly to examined students’ technology capability and their perception of social presence in online learning during covid-19 pandemic. Moreover, we also examined the role of learner characteristics as moderation variable in relationship between technology capability and social presence. A total of 380 people (students of batch 2017 from private university located in Bandung) have participated voluntarily as the respondents. Hypotheses testing were employed by Moderated Regression Analysis (MRA) technique. The results of this research were (1) technology capability significantly affect social presence; (2) learner characterictics significantly affect social presence; (3) learner characterictics significantly increased the relationship between technology capability and social presence. These findings clarify that online learning effectiveness is not only determined by students’ technology capability, but also students’ certain characteristics. In addition, the result of this study indicate that the role of technology capabilities is essential in online learning and associated with interactions during activities. Also, these results provide some important recommendations to all lecturers in university to develop an effective learning process during this pandemic.
Perspektywy budowy parku przemysłowo- technologicznego dla mieszkańców Zagłębia Miedziowego
Authors: PRZYBYLSKI Grzegorz 
Published: November 2020

W artykule przedstawiono perspektywy budowy parku przemysłowo-technologicznego zlokalizowanego na terenie gminy miejskiej oraz wiejskiej Lubin. Obszar ten charakteryzuje się monokulturą przemysłu miedziowego związanego z największym pracodawcą w regionie – KGHM Polska Miedź S.A. Działalność wydobywcza Polskiej Miedzi w perspektywie długookresowej będzie ograniczana. Z tego względu szuka się innych możliwości wykorzystania potencjału regionu. Wydaje się, że jednym z najbardziej obiecujących jest budowa parku przemysłowo-technologicznego. Zainteresowanie tym przedsięwzięciem okazują samorządy (lokalne samorządy, Województwo Dolnośląskie), Agencja Rozwoju Przemysłu, Krajowy Ośrodek Wsparcia Rolnictwa, przedstawiciele firmy KGHM Polska Miedź S. A. oraz przedstawiciele Kancelarii Prezesa Rady Ministrów.
Pemanfaatan Pelayanan Kesehatan pada Anak Indonesia: Pengaruh Kemiskinan dan Karakteristik Ibu
Authors: Sari Ririn Kuncaraning , Handayani Dwini 
Published: November 2020

Pemanfaatan pelayanan kesehatan merupakan salah satu upaya untuk meningkatkan status kesehatan, khususnya pada anak. Namun, kemiskinan dan karakteristik orang tua khususnya ibu sering kali menjadi faktor utama yang memengaruhi pemanfaatan pelayanan kesehatan pada anak. Penelitian ini menggunakan data Susenas 2017 dan Podes 2018 untuk melihat pengaruh kemiskinan dan karakteristik ibu terhadap pemanfaatan pelayanan kesehatan untuk rawat jalan pada anak. Unit analisis dalam penelitian ini adalah 50.437 anak yang memiliki keluhan kesehatan, terganggu aktifitas dalam sebulan terakhir dan tinggal bersama ibu kandung. Analisis data dilakukan secara deskriptif dan menggunakan regresi logistik. Hasil menunjukkan jika sekitar satu dari tiga anak tidak memanfaatkan pelayanan kesehatan untuk rawat jalan ketika sakit. Selanjutnya, dengan metode regresi logistik, terbukti jika kemiskinan keluarga berpengaruh signifikan dan negatif terhadap pemanfaatan pelayanan kesehatan untuk rawat jalan pada anak di Indonesia (OR=0,79). Sedangkan pendidikan dan status bekerja ibu berpengaruh positif dan signifikan. Penelitian ini menunjukkan perlunya memberikan kemudahan akses terhadap pelayanan kesehatan pada anak yang ada pada rumah tangga miskin, disamping perlunya meningkatkan pemberdayaan perem-puan, khususnya ibu untuk dapat meningkatkan pemanfaatan pelayanan kesehatan khususnya rawat jalan pada anak.
EPIDERMOLYSIS BULLOSA: CLINICAL OBSERVATION AND PRACTICAL ASPECTS OF TREATMENT
Authors: Babintseva A.G. , Gedeon I.V. , Godovanets Yu.D. , Godovanets O.S. , Petrov V.A. 
Published: November 2020

Epidermolysis bullosa (EB) is a heterogenous group of hereditary diseases characterized by blisters on the skin and mucous membranes resulting in scarring. General occurrence rate of the disease is 8-10 cases per 1 000 000 of childbirths, with the 1:1 ratio between boys and girl. In the majority of patients clinical signs of the disease appear at birth and under 1 year. There are four main EB types: simple, functional, dystrophic and Kindler syndrome. Nowadays more than 1000 mutations of 14 structural genes have been identified resulting in the development of different EB phenotypes. Pathogenesis of the disease is based on abnormal, lost or insufficient level of a specific protein, which plays a crucial role in adhesion of the epidermis and dermis. This case report presents a clinical case of EB in a newborn girl and practical aspects of its treatment at the early neonatal period. The girl was born from the II pregnancy, II delivery in normal physiological term of gestation assessed as having 8-9 scores by Apgar scale. Some areas of disturbed skin integrity on the lower limb with some aplasia, penicilli and exfoliation of the oral mucosa were found at birth. These areas underwent changes in the dynamics of the disease, but new ones continuously appeared. Individual topical treatment was prescribed considering the stage of wound healing; partial parenteral feeding was carried out with gradual transition to enteral feeding with breast milk through the orogastric tube. Consultations with specialists providing medical aid to children suffering from EB and close contacts with parent organizations promote professional care to these patients, especially at the early neonatal period.