bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the Role of Business Administration in Promoting Economic Development
Authors: Ye Xiaoli 
Published: September 2020

<p>As an important foundation for national development, economy is always being the focus of social construction. In order to promote better economic development, business administration needs to play a greater role to ensure the smooth operation of the economic market. Moreover, with the improvement of the development speed of economic globalization, it is both an opportunity and a challenge to China’s economic development. Therefore, it is necessary to strengthen business administration to seize opportunities and embrace challenges. Therefore, all enterprises are carrying out administration innovation to improve the efficiency of business administration. Thus, this article analyzes the role of business administration in promoting economic development, hoping to give some guidance to enterprises to promote the long-term and stable development of China’s economy.</p>
Development Strategy of Agricultural Product Cold Chain Logistics under Low Carbon Economy
Authors: Zhang Qi 
Published: September 2020

<p>The cold chain logistics of agricultural products is closely related to people’s lives and production. With the development and progress of society and the improvement of people’s income level, the cold chain logistics industry came into being and provided a guarantee for the development of agricultural product transactions. Based on the current development status of China’s agricultural product cold chain logistics industry, this paper discusses the problems and proposes countermeasures and suggestions based on the causes and effects of the problems.</p>
Relación entre la intención de ser activo y la actividad física extraescolar
Authors: Pérez Soto Juan José , García Cantó Eliseo , Guillamón Andrés Rosa , Rodríguez García Pedro Luís , Moral García Jose Enrique , López García Sergio 
Published: September 2020

El objetivo del presente estudio fue relacionar la intención de ser activo y la práctica de actividad física extraescolar en 408 escolares. Para la medición de la actividad física extraescolar se empleó el instrumento de recordatorio de la actividad física extraescolar (PDPAR) y para la intención de ser activo el instrumento de Medición de la Intencionalidad de Ser Activo (MIFA). Los resultados mostraron asociaciones significativas entre la intención de ser activo y las medias de minutos de actividad física extraescolar de moderada a vigorosa intensidad en varones y en mujeres. Se observa como los niveles de actividad física aumentan conforme se incrementa la intencionalidad de ser activo.
Aspectos a considerar al abordar el cambio climático desde el enfoque de la ecología política
Authors: Langhoff María Laura 
Published: September 2020

El presente trabajo se propone abordar desde la perspectiva de la ecología política latinoamericana, una serie de aspectos del proceso de cambio climático. Estos son: el fomento del extractivismo en Latinoamérica y las movilizaciones de carácter socio ambiental que fueron surgiendo como consecuencia directa; las relaciones de poder que se evidencian entre las instituciones y países que motorizan la investigación y discusión a nivel global, desatendiendo alternativas para controlar efectos a nivel local; y, por último, el cambio climático como un discurso hegemónico que corre el riesgo de transformarse solo en eslogan, lo cual lleva a plantearse si no es adecuado hablar de crisis socio ambiental.
El marco teórico que brinda la ecología política latinoamericana se asienta en una profunda reflexión de la historia signada por la conquista. En su análisis son centrales las relaciones entre las elites políticas, económicas y culturales con las metrópolis y el despojo de recursos naturales.
La metodología utilizada se centró en la lectura y análisis de bibliografía tanto teórica como estudios de caso y notas periodísticas que se han producido en los últimos años en relación al tema.
La conclusión que se plantea destaca que el proceso de cambio climático se convierte en un eslogan que acaba conviviendo con actividades extractivas que contribuyen al agravamiento de dicho proceso, las cuales se continúan impulsando en Latinoamérica. Es necesario profundizar el pensamiento y prácticas decoloniales.

Palabras clave: ecología política; cambio climático; crisis socio ambiental; extractivismo.
Hubungan Kadar Periostin Serum dan Nilai Asthma Control Test pada Pasien Asma di RSUD Dr. Soetomo Surabaya
Authors: Yaniswari Ni Made Dwita , Amin Muhammad 
Published: September 2020

Background: Asthma is a heterogenous disease composed of various phenotype. Chronic airway inflammation are fundamental features of asthma. The main treatment of asthma is corticosteroid. The administration of inhaled corticosteroids will reduce the inflammatory process in asthma. Even with adequate inhaled corticosteroid treatment, there are still patients who develop symptoms with lower asthma control test score. Periostin is an extracellular matrix protein as the best single systemic biomarker for assessing tissue eosinophilia, airway remodeling in uncontrolled asthma. The objective of this study was to examine whether serum periostin is correlated with ACT in asthmatic patients. Methods: This research was an observational analytical with cross sectional design conducted in outpatient clinic Dr. Soetomo General Hospital Surabaya for 3 months. In total, we found 40 asthmatic patients who were qualified to the inclusion and exclusion criteria as the research samples. The questionnaire was filled in to assess the Asthma Control Test and venous blood tests to measure serum periostin levels using Sandwich Enzyme-Linked Immunosorbent Assay (ELISA) method. Results: The mean periostin level profile of the sample was 94.82 ± 19.21 ng/ml and the median was 94.7 ng/ml. The average ACT score was 16.55 ± 2.93 with 85% were uncontrolled asthma. The results of the independent t-test showed serum periostin levels and the level of asthma control based on ACT score in asthmatics patients had a significant correlation (p = 0.024). Conclusion: There is a significant correlation between serum periostin levels and ACT score in asthmatic patients.
Team Approach: Developmental Dysplasia of the Hip
Authors: Young Joseph R. , Anderson Matthew J. , O’Connor Casey M. , Kazley Jillian M. , Mantica Abigail L. , Dutt Vivek 
Published: September 2020

» Developmental dysplasia of the hip (DDH) encompasses a wide spectrum of hip disorders, including neonatal instability, acetabular dysplasia, hip subluxation, and frank dislocation of the hip. It is a common disorder, with a reported incidence of between 0.1% and >10% of live births.» Coordinated, interdisciplinary care is important to achieving successful outcomes. This starts with accurate assessment of risk factors in the prenatal period, thorough clinical examination by the primary care provider at all well-child visits, and early referral to a pediatric orthopaedic surgeon for prompt diagnosis and treatment.» Early diagnosis and prompt treatment is critical for an excellent outcome. Ongoing, open communication between clinicians is essential for the effective coordination of care.» Treatment options vary depending on the age of presentation. A Pavlik harness (dynamic hip abduction orthosis) is used for children up to 6 months of age. A more rigid abduction orthosis may be used if treatment with a Pavlik harness is unsuccessful, with a closed reduction and spica cast being the next step if needed for children up to 18 months of age. Finally, open reduction with possible concomitant femoral and/or pelvic osteotomies is the surgical option in an older child, when necessary. In general, the later the child is diagnosed with and treated for DDH, the greater the risk of a nonoptimal outcome.» Depending on the severity of the condition, children with DDH may need to be followed closely until skeletal maturity so as not to miss the diagnosis of asymptomatic residual hip dysplasia, which can predispose patients to early hip arthritis.
Estimating averting expenditure in domestic water use: evidence from Ghana
Authors: Amoah Anthony 
Published: September 2020

AbstractSafe water is described as an important resource for the survival of mankind. The outbreak of the Covid-19 pandemic has made safe water ‘super’ important and critical for the survival of mankind. Most developing countries, especially in Africa, incur additional costs in order to enjoy improved, if not safe domestic water supply. Using the averting expenditure method, this study estimates how much urban households in the Greater Accra Region of Ghana spend to improve the quality of domestic water they use. The study provides evidence that households spend Ghs84.30 ($14.70) per month, which constitutes 13.25% of their income. These estimates are very informative to the supplier in determining the economic viability of making the required quality of water available to households.
Flavonoids from Stem and Leaf of Scutellaria Baicalensis Georgi Inhibit the Phosphorylation on Multi-sites of Tau Protein Induced by Okadaic Acid and the Regulative Mechanism of Protein Kinases in Rats
Authors: Gao Yang , Wang Xiao-Qing , Ma Shuai , Dong Yong-Cai , Shang Ya-Zhen 
Published: September 2020

Aim:
The present study aims to investigate the effect of flavonoids from stem and leaf
of Scutellaria Baicalensis Georgi (SSF) on multi-sites phosphorylation of tau protein in the cerebral
cortex and hippocampus of rats induced by okadaic acid (OA) and the regulative mechanism
of the protein kinases.

Methods:
The model of AD-like memory impairment and neuronal injuries was established in
male SD rats who were microinjected with OA (200 ng/kg) to establish a memory impairment model
and screened for successful model rats by Morris water maze on day 21 after surgery. The successful
model rats were continuously administered with intragastric infusion (ig) SSF 25, 50 and
100 mg/kg or Ginkgo biloba leaves flavonoids (GLF) 200 mg/kg for 36 d. The relative protein expressed
levels of phosphorylated tau protein at sites of Ser199, Ser202, Ser214, Ser404 and
Thr231, protein kinases (CDK5, PKA, pTyr216-GSK3β and pSer9-GSK3β) were detected by Western
blotting.

Results:
The relative protein expressed levels of p-tau(Ser199), p-tau(Ser202), p-tau(Ser214), p--
tau(Ser404), p-tau(Thr231) and pTyr216-GSK3β were significantly increased in both cerebral cortex
and hippocampus regions of the model rats subjected to intracerebroventricular injection of OA
(P<0.01), while the protein expressed levels of CDK5, PKA and pSer9-GSK3β (P<0.01) were reduced.
SSF can dramatically reverse these increments in phosphorylated tau protein levels
(P<0.01) and differently regulate the protein expressed levels of CDK5, PKA and GSK3β (P<0.01)
in rats’ cerebral cortex and hippocampus induced by OA. GLF also exhibit a similar effect to SSF.

Conclusion:
The results demonstrated that SSF could inhibit the hyperphosphorylation of tau in
rats’ cerebral cortex and hippocampus induced by microinjection of OA, which may be related to
the activities of protein kinase CDK5, PKA and GSK3β.
In Silico ADMET Evaluation of Natural DPP-IV Inhibitors for Rational Drug Design against Diabetes
Authors: Singla Rajeev K. , Shen Bairong 
Published: September 2020

Background:
As a metabolic and lifestyle disorder, diabetes mellitus poses a prodigious health risk. Out
of the many key targets, DPP-IV is one of the very imperative therapeutic targets for the treatment of diabetic patients.

Methods:
In our current study, we have done the in silico simulations of ADME-T properties for naturally originated
potent DPP-IV inhibitors like quinovic acid, stigmasterol, quinovic acid-3-beta-D-glycopyranoside, zygophyloside E,
and lupeol. Structural topographies associated with different pharmacokinetic properties have been systematically
assessed.

Results:
Glycosylation on quinovic acid is found to be noteworthy for the improvement of pharmacokinetic and
toxicological properties, which leads to the prediction that zygophyloside E can be further tailored down to get the
lead DPP-IV inhibitor.

Conclusion:
This assessment provides useful insight into the future development of novel drugs for the treatment of
diabetes mellitus.
Trends in Nutrient Intakes of Indian Adults: Computerized Diet Analysis (CDiet) of Cross-sectional Surveys between 1998 and 2015
Authors: Chiplonkar Shashi A. 
Published: September 2020

Background:
Time trends in nutrient intakes have been reported from household food
consumption using food table values. However, accurate estimates of trends over the past decade in
nutrient intakes using computerised nutrient analysis of Indian diets are lacking.

Objectives:
To examine changes in nutrient intakes of Indian adults by re-analysis of dietary food
intakes between 1998 and 2015 with computerized diet analysis software, CDiet.

Methods:
Diets of men and women (20-60 years) from Western India in 1998-2000 (n=559), in
2007-2009 (n=638), and in 2013-2015 (n=1073) were assessed mostly using semi-quantitative
food frequency questionnaire by interview method. Daily nutrient intakes were calculated with laboratory-
based food composition database using computerised diet analysis software (CDiet). Physical
activity was assessed through a structured questionnaire and classified as; sedentary, light, and
moderate activity level (PAL). Trends in mean nutrient intakes were evaluated using generalised
linear regression model.

Results:
Over the past 17 years, trend estimates of energy intakes adjusted for age and PAL
showed a decline of 11 to 19.7% for men, whereas an insignificant increase of 1 to 3% in women.
Higher reduction (23 to 45%) was seen in intakes of iron, riboflavin, thiamine, and folate than in
other micronutrients. Men with sedentary activity increased by 16.8%, whereas women having
light/moderate activity increased by 7.2%.

Conclusions:
A decreasing trend in nutrient intakes over the last 17 years and an increase in sedentary
behavior suggested the need for change in lifestyle and increased consumption of nutrient--
dense foods by Indian adults.
In Silico Study of the Active Compounds of Lindera aggregata (Sims) Kosterm as Anti-coronavirus
Authors: Firdiana Elok R. , Renjana Elga , Ningrum Linda W. , Angio Melisnawati H. , Nikmatullah Muhamad , Rizal Syaiful 
Published: September 2020

Background:CoVID-19, caused by a new type of coronavirus named SARS-CoV-2, has become a pandemic. Together with SARS-CoV and MERS-CoV, CoVID-19 is a large global outbreak of coronavirus infection; however, its rate of spread is much higher. Since the vaccines and anti-SARS-CoV-2 have not been found, a faster control mechanism is much needed. Traditional herbs have shown the potential for this purpose, as has been demonstrated by the Chinese Government with a high success rate. One of the herbs used was Lindera aggregata, which is part of the collection in Purwodadi Botanic Gardens.Objectives:Through in silico study, this research aims to reveal the secondary metabolites contained in L. aggregata that have the potential to serve as anti-SARS-CoV-2 medication as well as showcase their inhibitory mechanisms.Methods:The research was conducted through molecular docking analysis of terpenoids and alkaloids contained in the root of L. aggregata, with target proteins 3CLpro, PLpro, Spike, and ACE 2 playing a role in SARS-CoV-2 infection.Result:All analyzed compounds tended to interact with all four target proteins with different binding affinity values, but the interaction seemed stronger with 3CLpro and Spike. Terpenoids, linderane and linderalactone had the strongest interaction tendency with 3CLpro, PLpro, and Spike; the compound norboldine, an alkaloid, had the strongest interaction with ACE 2, with a binding affinity value of -8.2 kcal/mol.Conclusion:Terpenoids and alkaloids contained in the root of L. aggregata, which caused inhibition of adsorption and replication of SARS-CoV-2, could serve as anti-SARS-CoV-2.
A Critical Overview of Systematic Reviews of Chemotherapy for Advanced and Locally Advanced Pancreatic Cancer using both AMSTAR2 and ROBIS as Quality Assessment Tools
Authors: Dang Amit , Chidirala Surendar , Veeranki Prashanth , Vallish B.N. 
Published: September 2020

Background:
We performed a critical overview of published systematic reviews (SRs) of chemotherapy for
advanced and locally advanced pancreatic cancer, and evaluated their quality using AMSTAR2 and ROBIS tools.

Materials and Methods:
PubMed and Cochrane Central Library were searched for SRs on 13th June 2020. SRs with metaanalysis which included only randomized controlled trials and that had assessed chemotherapy as one of the treatment
arms were included. The outcome measures, which were looked into, were progression-free survival (PFS), overall survival (OS), and adverse events (AEs) of grade 3 or above. Two reviewers independently assessed all the SRs with both
ROBIS and AMSTAR2.

Results:
Out of the 1,879 identified records, 26 SRs were included for the overview. Most SRs had concluded that gemcitabine-based combination regimes, prolonged OS and PFS, but increased the incidence of grade 3-4 toxicities, when
compared to gemcitabine monotherapy, but survival benefits were not consistent when gemcitabine was combined with
molecular targeted agents. As per ROBIS, 24/26 SRs had high risk of bias, with only 1/26 SR having low risk of bias. As
per AMSTAR2, 25/26 SRs had critically low, and 1/26 SR had low, confidence in the results. The study which scored
‘low’ risk of bias in ROBIS scored ‘low confidence in results’ in AMSTAR2. The inter-rater reliability for scoring the
overall confidence in the SRs with AMSTAR2 and the overall domain in ROBIS was substantial; ROBIS: kappa=0.785,
SEM=0.207, p<0.001; AMSTAR2: kappa=0.649, SEM=0.323, p<0.001.

Conclusion:
Gemcitabine-based combination regimens can prolong OS and PFS but also worsen AEs when compared to
gemcitabine monotherapy. The included SRs have an overall low methodological quality and high risk of bias as per AMSTAR2 and ROBIS respectively.
Comparison of Dapaglifozin and Liraglutide in Patients with Poorly Controlled Type 2 Diabetes Mellitus: a 24-week, Open, Double-centered, Head to Head Trial
Authors: Jiang Jianjia , Lin Lu , Chen Pin 
Published: September 2020

Objective:
To evaluate the efficacy and treatment satisfaction of dapagliflozin and liraglutide
in T2DM patients with glucose poorly controlled after triple therapy.

Methods:
In addition to the original therapeutic regimen, dapagliflozin (n=83) and liraglutide
(n=89) once a day were added, respectively. Height, body weight, waist circumference, and blood
pressure were recorded. FBG, 2hPBG, HbA1c, fasting C-peptide, HOMA-IR, blood lipid, eGFR,
BUA and DTSQ were detected before the treatment and after 24 weeks of treatment.

Results:
At the end of 24 weeks of treatment, a follow-up visit was completed for 79 patients in the
dapagliflozin group and 77 patients in the liraglutide group. The body weight of the patients in the
dapagliflozin group and the liraglutide group decreased significantly (P<0.05). The HbA1c level in
the dapagliflozin group decreased from 8.96 ± 1.23% to 7.03 ±0.74% (P<0.01), more than that in
the liraglutide group, namely, from 8.99 ± 1.34% to 7.24 ±0.77% (P<0.01). After 12 weeks of
treatment, eGFR in the dapagliflozin group first decreased and then increased after 12 weeks of
treatment. The percentages of patients achieving combined endpoints in the two groups were of no
statistical significance (P=0.204). And there were mild adverse events in both groups.

Conclusion:
The add-on treatment of dapagliflozin and liraglutide had promising clinical outcomes
in patients with T2DM and poorly controlled glucose after triple therapy, which include the
improvement in blood glucose, insulin resistance, SBP, and renal function. However, the overall
treatment satisfaction was higher in the dapagliflozin group.
Amorphous Solid Dispersion Based Oral Disintegrating Film of Ezetimibe: Development and Evaluation
Authors: Sudheer Preethi , Shrestha Sangam , Narayana Kavitha A. 
Published: September 2020

Background:
Ezetimibe is a cholesterol-lowering agent with an oral bioavailability of
50% by virtue of its poor solubility and extensive hepatic and intestinal metabolism.

Objective:
The study aimed to overcome low bioavailability issues of ezetimibe by formulating an
oral disintegrating film.

Methods:
The low solubility of ezetimibe was undertaken, preparing solid dispersions using mannitol,
β-cyclodextrin, and urea. The mannitol solid dispersion assimilated oral disintegrating film was
prepared and optimized using 23 factorial design, where the concentration of film formers hydroxypropyl
methylcellulose (K5& K15) (X1and X2) and super disintegrant, sodium starch glycolate
(X3) was used as factors on the response disintegration time (Y). The films were evaluated for
physical properties, time of disintegration, and drug release profiles.

Results :
Mannitol solid dispersion (1:2 ratio) based on the superior drug content, solubility and in
vitro release profile was preferred in film formation. The low crystalline nature of the solid dispersion
was very evident by the absence of prominent peaks in the X-Ray diffraction pattern and the
reduced peak intensity of melting endotherms. The correlation coefficient (R2) and statistical parameter
analysis of variance specify the implication of linear factors on responses, which is apparent
from confidence intervals (P-values) less than 0.05. The in vitro release profile of all the eight formulations
(F1-F8) in a phosphate buffer solution of pH 6.8 revealed a significant increment in comparison
to ezetimibe.

Conclusion:
The study revealed that the formulation approach could overcome the biopharmaceutical
challenge of solubility as well as low bioavailability issues of ezetimibe.
A Review of Aristolochia indica: Ethnomedicinal Uses, Phytochemistry, Pharmacological and Toxicological Effects
Authors: Padhy Gopal Krishna 
Published: September 2020

Background:
Aristolochia indica L. of the family Aristolochiaceae is a twining perennial
herb with an ancient history of medicinal use. In the Indian Ayurvedic system, it is used for the
treatment of snake venom, scorpion venom, pimple, fever and worm infections.

Objective:
This studay aimed to make accessible the current information on the traditional uses,
phytochemistry, pharmacology and toxicology of Aristolochia indica. Additionally, the purpose
was to emphasize the potential uses of this plant to treat various diseases and to bring a foundation
for further research.

Methods:
The present review is carried out by compiling literature from 1935 to 2020, concerning
the morphology, traditional uses, phytochemistry, pharmacological activities, and toxicological aspects
of Aristolochia indica.

Results:
Diverse chemical compounds including aristolochic acids, aristolactam, Phenanthrenes, alkaloids,
lignans, steroids and terpenes have been isolated from this plant. Mostly in-vivo models indicated
several pieces of evidence on the use of this plant particularly to regulate fertility. Few in--
vivo studies also proved the usefulness of this plant in inflammation and diabetes. In some in-vitro
studies, the anti-snake venom, larvicidal, and anti-oxidant properties have been proved.

Conclusion:
Preclinical studies have demonstrated remarkable activity that supports the conventional
use of the plant as an antivenum, antifertility, antimicrobial and anti-inflammatory agent. Although
few phytochemicals isolated (aristolic acid, (12S)-7,12-secoishwaran-12-ol, aristololactam-
I N-β-D-glucoside, aristolochic acids, β-sitosterol, (-)hinokinin and aristolactam-I) from the
plant exhibited remarkable biological activity, it was only confined to preclinical studies. Even
though the isolated aristolochic acids showed significant anti-snake venom activity, but it was
found to be nephrotoxic and mutagenic. More detailed safety data pertaining to the dose of crude
extracts or pure compounds needs to be generated.