bluuebunny/crossref_metadata_2025_split huggingface dataset:
$${{\mathbb {Z}}}_2\times {{\mathbb {Z}}}_2$$-graded mechanics: the classical theory
Authors: Aizawa N. , Kuznetsova Z. , Toppan F. 
Published: July 2020

Abstract$${{\mathbb {Z}}}_2\times {{\mathbb {Z}}}_2$$Z2×Z2-graded mechanics admits four types of particles: ordinary bosons, two classes of fermions (fermions belonging to different classes commute among each other) and exotic bosons. In this paper we construct the basic $${{\mathbb {Z}}}_2\times {{\mathbb {Z}}}_2$$Z2×Z2-graded worldline multiplets (extending the cases of one-dimensional supersymmetry) and compute, based on a general scheme, their invariant classical actions and worldline sigma-models. The four basic multiplets contain two bosons and two fermions. They are (2, 2, 0), with two propagating bosons and two propagating fermions, $$(1,2,1)_{[00]}$$(1,2,1)[00] (the ordinary boson is propagating, while the exotic boson is an auxiliary field), $$(1,2,1)_{[11]}$$(1,2,1)[11] (the converse case, the exotic boson is propagating, while the ordinary boson is an auxiliary field) and, finally, (0, 2, 2) with two bosonic auxiliary fields. Classical actions invariant under the $${{\mathbb {Z}}}_2\times {\mathbb {Z}}_2$$Z2×Z2-graded superalgebra are constructed for both single multiplets and interacting multiplets. Furthermore, scale-invariant actions can possess a full $${{\mathbb {Z}}}_2\times {\mathbb {Z}}_2$$Z2×Z2-graded conformal invariance spanned by 10 generators and containing an sl(2) subalgebra.
Data-driven extraction of heavy quark diffusion in quark-gluon plasma
Authors: Li Shuang , Liao Jinfeng 
Published: July 2020

AbstractHeavy quark production provides a unique probe of the quark-gluon plasma transport properties in heavy ion collisions. Experimental observables like the nuclear modification factor $$R_\mathrm{AA}$$RAA and elliptic anisotropy $$v_\mathrm{2}$$v2 of heavy flavor mesons are sensitive to the heavy quark diffusion coefficient. There now exist an extensive set of such measurements, which allow a data-driven extraction of this coefficient. In this work, we make such an attempt within our recently developed heavy quark transport modeling framework (Langevin-transport with Gluon Radiation, LGR). A question of particular interest is the temperature dependence of the diffusion coefficient, for which we test a wide range of possibility and draw constraints by comparing relevant charm meson data with model results. We find that a relatively strong increase of diffusion coefficient from crossover temperature $$T_c$$Tc toward high temperature is preferred by data. We also make predictions for Bottom meson observables for further experimental tests.
Cantando a Torá
Authors: Dellarole Pedro 
Published: July 2020

Este estudo pretende suscitar o saber da antiga e rica tradição milenar de cantar e reinterpretar a torá ou Bíblia hebraica conhecida por Te amim ha-mikra ou cantilenas. Este fenômeno litúrgico musical permitiu a um determinado grupo de pessoas a estruturar um sistema organizacional com a qual realizaram a implementação de um agrupamento de sons funcional de leitura Bíblica que mais tarde veio a se tornar notações musicais que se propagaram por todas as comunidades judaicas, conservando suas particularidades assim como a assimilação do costume local pelos judeus, externalizando desta maneira, através da música, suas origens sem deixar de apropiar-se da tradição por onde passavam.
The North Atlantic as a Driver of Summer Atmospheric Circulation
Authors: Osborne Joe M. , Collins Mat , Screen James A. , Thomson Stephen I. , Dunstone Nick 
Published: July 2020

AbstractSkill in seasonal forecasts in the Northern Hemisphere extratropics is mostly limited to winter. Drivers of summer circulation anomalies over the North Atlantic–European (NAE) sector are poorly understood. Here, we investigate the role of North Atlantic sea surface temperatures (SSTs) in driving summer atmospheric circulation changes. The summer North Atlantic Oscillation (SNAO), the leading mode of observed summer atmospheric circulation variability in the NAE sector, is correlated with a distinct SST tripole pattern in the North Atlantic. An atmospheric general circulation model is used to test whether there are robust atmospheric circulation responses over the NAE sector to concurrent SSTs related to the SNAO. The most robust responses project onto the summer east Atlantic (SEA) pattern, the second dominant mode of observed summer atmospheric circulation variability in the NAE sector, and are most evident at the surface in response to tropical SSTs and at altitude in response to extratropical SSTs. The tropical-to-extratropical teleconnection appears to be due to Rossby wave propagation from SST anomalies, and in turn precipitation anomalies, in the Caribbean region. We identify key biases in the model, which may be responsible for the overly dominant SEA pattern variability, compared to the SNAO, and may also explain why the responses resemble the SEA pattern, rather than the SNAO. Efforts to eradicate these biases, perhaps achieved by higher-resolution simulations or with improved model physics, would allow for an improved understanding of the true response to North Atlantic SST patterns.
The Value of Initialization on Decadal Timescales: State-Dependent Predictability in the CESM Decadal Prediction Large Ensemble
Authors: Christensen H. M. , Berner J. , Yeager S. 
Published: July 2020

AbstractInformation in decadal climate prediction arises from a well-initialized ocean state and from the predicted response to an external forcing. The length of time over which the initial conditions benefit the decadal forecast depends on the start date of the forecast. We characterize this state-dependent predictability for decadal forecasts of upper ocean heat content in the Community Earth System Model. We find regionally dependent initial condition predictability, with extended predictability generally observed in the extratropics. We also detect state-dependent predictability, with the year of loss of information from the initialization varying between start dates. The decadal forecasts in the North Atlantic show substantial information from the initial conditions beyond the 10-yr forecast window, and a high degree of state-dependent predictability. We find some evidence for state-dependent predictability in the ensemble spread in this region, similar to that seen in weather and subseasonal-to-seasonal forecasts. For some start dates, an increase of information with lead time is observed, for which the initialized forecasts predict a growing phase of the Atlantic multidecadal oscillation. Finally we consider the information in the forecast from the initial conditions relative to the forced response, and quantify the crossover time scale after which the forcing provides more information. We demonstrate that the climate change signal projects onto different patterns than the signal from the initial conditions. This means that even after the crossover time scale has been reached in a basin-averaged sense, the benefits of initialization can be felt locally on longer time scales.
Assessing risks of violent extremism in depressive disorders: Developing and validating a new measure of Sympathies for Violent Protest and Terrorism
Authors: Bhui Kamaldeep , Otis Michaela , Halvorsrud Kristoffer , Freestone Mark , Jones Edgar 
Published: July 2020

Objective: Clinicians are tasked with assessing the relationship between violence and mental illness. Yet, there is now a legal expectation in some countries that public services, including health professionals, assess risk of violent extremism – with few available measures. We previously developed a new measure of Sympathies for Radicalisation, using items that measure Sympathies for Violent Protest and Terrorism. In this paper, we present the detailed psychometric properties of a reduced item measure of Sympathies for Violent Protest and Terrorism. We use data from two studies to test replication and then validity against outcomes of self-reported violence and convictions in the entire sample and in those with depressive symptoms. Methods: Data from two cross-sectional neighbourhood surveys, consisting of Pakistani and Bangladeshi adults (survey 1, n = 608) and White British and Pakistani adults (survey 2, n = 618), were used to undertake confirmatory factor analysis of Sympathies for Radicalisation and produce a short measure of Sympathies for Violent Protest and Terrorism. Survey 2 data were used to test the Sympathies for Violent Protest and Terrorism’s convergent validity to classify presence/absence of violence and convictions in the whole sample and for subgroups by depressive disorder. Results: The seven-item measure’s structure was a consistent measure of extremist attitudes across the two surveys. A threshold score of zero to classify violence was optimal (specificity = 89.7%; area under the curve = 0.75), but sensitivity to a risk of violence was poor (34.5%). The short version Sympathies for Radicalisation was a better classifier of violence in respondents with depression, dysthymia or both (area under the curve = 0.78) than respondents with neither (area under the curve = 0.69; β = 0.62, 95% confidence interval = [−0.67, 1.92]; standard error = 0.66). Conclusion: The seven-item measure of Sympathies for Violent Protest and Terrorism is an accessible and valid measure for clinical assessments and helpfully identifies low risk of violence. It enables clinicians to conduct detailed assessments of people endorsing one or more of the items, although further research is needed.
Bilateral Sensorineural Hearing Loss Associated With Nivolumab Therapy for Stage IV Malignant Melanoma
Authors: Tampio Alex J. F. , Dhanireddy Swetha , Sivapiragasam Abirami , Nicholas Brian D. 
Published: July 2020

Objectives: Present the case of a 67-year-old male with stage IV malignant melanoma who presented with uveitis and sensorineural hearing loss (SNHL) while on nivolumab and review the literature for likely etiologies. Methods: A retrospective case review was conducted. The current literature was accessed to inquire about possible pathologic mechanisms and treatment options. Results: A 67-year-old male with stage IV malignant melanoma was treated with nivolumab. During therapy, the patient presented with bilateral uveitis, vertigo, and bilateral moderate sloping to moderate–severe SNHL. After 4 cycles of nivolumab, restaging scans showed no evidence of disease. Nivolumab was discontinued. The patient was placed on a 3-week course of systemic high dose steroids and topical steroid eye drops. Both his uveitis and SNHL resolved after treatment. Nivolumab enhances the antitumor activity of T cells by inhibiting the programed death-1 receptor. While nivolumab has shown great promise in the treatment of many types of cancers, it has also been associated with many autoimmune side effects. We propose the etiology of this 67-year-old male’s SNHL and uveitis are the result of an autoimmune process secondary to an augmented T cell response induced by nivolumab. Conclusion: While immunotherapeutic agents such as nivolumab have shown great promise in the treatment of cancer, one should maintain an awareness and caution of autoimmune side effects such as uveitis and SNHL.
Follow-Up Phone Interviews and Attendance Motivation From A Free Head and Neck Cancer Screening
Authors: Urdang Zachary D. , Rosales David H. , Chen QiLiang , Li Ryan J. , Andersen Peter E. , Gross Neil D. , Clayburgh Daniel R. 
Published: July 2020

Introduction: Head and Neck Cancer Awareness and Screening Programs (HNCASP) are popular community outreach events hosted by academic and community otolaryngology departments. However, long-term follow-up of participants is lacking. Patients and Methods: Participants of a HNCASP held at an academic cancer center prospectively filled out demographic and risk factor surveys followed by HNC screening examination. A phone interview was conducted for participants between 2012 and 2016 with suspicious findings to assess outcomes. Results: Participants were largely Caucasian, female, and had health insurance, reflecting the setting at an academic medical center. Despite this, there were 156 (16.8%) positive screenings; 47 of these completed follow up interviews. Twelve (1.1% of all participants) cancer cases were confirmed. Discussion: A significant proportion of HNCASP participants benefited from this screening opportunity. Education regarding HNC is the primary benefit and motivational factor for attendance of HNCASPs, although a significant subset of patients was identified that needed follow-up, and several cancers were detected.
Association between lipid profiles and arterial stiffness: A secondary analysis based on a cross-sectional study
Authors: Wang Long , Zhi Fu , Gao Beibei , Ni Jie , Liu Yihai , Mo Xuming , Huang Jinyu 
Published: July 2020

Objectives The relationship between lipid levels and arterial stiffness remains controversial. Therefore, we aimed to determine the relationship between lipid profiles and brachial–ankle pulse wave velocity (baPWV) as an indicator of arterial stiffness. Methods A total of 909 participants aged 24 to 84 years were stratified into four baPWV quartiles in our study. Serum lipids, baPWV, and other variables of the participants were measured. Univariable and multivariable linear regression analyses were used to examine the relationships between lipid parameters and baPWV. Results The highest baPWV quartile group had higher aspartate transaminase, alanine aminotransferase, plasma glucose, total cholesterol, triglyceride (TG), and low-density lipoprotein cholesterol levels and maximum ankle–brachial index, and lower high-density lipoprotein cholesterol levels and estimated glomerular filtration rate. Univariate regression analysis showed that total cholesterol, TG, and low-density lipoprotein cholesterol levels were positively related and high-density lipoprotein cholesterol levels were negatively related to baPWV. After adjusting for age, body mass index, smoking status, aspartate transaminase, alanine aminotransferase, plasma glucose, and estimated glomerular filtration rate, only TG levels were correlated with baPWV (β = 0.075). Conclusions Four lipid variates are associated with arterial stiffness, and TG levels are positively related to arterial stiffness, independent of cardiovascular risks and liver function.
Practice-Based Research Networks in Stakeholder-Driven Social Work Research
Authors: Kelly Erin L. , Davis Lisa , Holguin Monique , Gaona Lizbeth , Pahwa Rohini , Lee Sae , Pancake Laura , Murch Lezlie , Giambone Leslie , Brekke John 
Published: July 2020

Purpose: The field of social work is evolving toward community-engaged, stakeholder-driven research in the context of evidence-based practice (EBP) and practice-based evidence (PBE). Methods: We propose that practice-based research networks (PBRNs) are an approach to conducting stakeholder-driven research that can be uniquely valuable for the field of social work. Results: We define the concept of a PBRN and demonstrate how it can address the development of complementary agendas for service improvement, social work science, policy development and advocacy, as well as highlight the challenges and benefits of participating in a PBRN. We provide details of our experiences with a mental health–based PBRN in Los Angeles County, the Recovery-Oriented Care Collaborative, to illustrate the processes outlined and inform our recommendations. Conclusions: PBRNs are an important form of community-based participatory research, which can help the field of social work with reconciling EBPs and PBE to improve service delivery.
Secondary Palate Development in the Dog (Canis lupus familiaris)
Authors: Freiberger Katharina , Hemker Shelby , McAnally Ryan , King Rachel , Meyers-Wallen Vicki N. , Schutte Brian C. , Fyfe John C. 
Published: July 2020

Objective: To investigate the gestational timing of morphologic events in normal canine secondary palate development as a baseline for studies in dog models of isolated cleft palate (CP). Methods: Beagle and beagle/cocker spaniel-hybrid fetal dogs were obtained by cesarean-section on various days of gestation, timed from the initial rise of serum progesterone concentration. Morphology of fetal heads was determined by examining serial coronal sections. Results: On gestational day 35 (d35), the palatal shelves pointed ventrally alongside the tongue. On d36, palatal shelves were elongated and elevated to a horizontal position above the tongue but were not touching. On d37, palatine shelves and vomer were touching, but the medial epithelial seam (MES) between the apposed shelves remained. Immunostaining with epithelial protein markers showed that the MES gradually dissolved and was replaced by mesenchyme during d37-d44, and palate fusion was complete by d44. Examination of remnant MES suggested that fusion of palatal shelves began in mid-palate and moved rostrally and caudally. Conclusion: Palate development occurs in dogs in the steps described in humans and mice, but palate closure occurs at an intermediate time in gestation. These normative data will form the basis of future studies to determine pathophysiologic mechanisms in dog models of CP. Added clinical significance is the enhancement of dogs as a large animal model to test new approaches for palate repair, with the obvious advantage of achieving full maturity within 2 years rather than 2 decades.
Effect of a struvite dissolution diet in cats with naturally occurring struvite urolithiasis
Authors: Tefft Karen M , Byron Julie K , Hostnik Eric T , Daristotle Leighann , Carmella Victoria , Frantz Nolan Z 
Published: July 2020

Objectives The aim of the study was to determine the efficacy of the low struvite relative supersaturation diet in dissolution of feline struvite cystoliths. Methods This was a prospective, open-label, two-center study. Twelve client-owned cats were enrolled based on the radiographic appearance of their uroliths and urinalysis parameters. Cats were fed the test diet exclusively for up to 56 days. Cats were radiographed every other week until radiographic evidence of dissolution occurred or the end of the study period was reached. Cats with radiographically apparent uroliths at the end of the study period underwent cystotomy for stone retrieval and analysis. Results Nine of the 12 cats completed the study. Eight experienced radiographic dissolution; seven of these had complete dissolution within the first month of treatment. One cat, whose owner declined cystotomy after partial dissolution at day 56, had complete radiographic resolution at 70 days of treatment. Two calcium oxalate urolith cores were removed from a cat that had partial radiographic dissolution. Conclusions and relevance The test diet was successful in dissolving suspected struvite cystoliths. As this diet is suitable for maintenance feeding of adult cats, it may be a suitable choice for long-term prevention of feline struvite urolithiasis.
Bcl-2, p53, and Ki-67 expression in pterygium and normal conjunctiva and their relationship with pterygium recurrence
Authors: Turan Meydan , Turan Gulay 
Published: July 2020

Purpose: Pterygium is a common lesion of the ocular surface, and its etiology and pathogenesis are still uncertain. This study aimed to investigate the role of apoptosis and proliferation in pterygium formation and recurrence. Materials and methods: In this study, p53, Bcl-2, and Ki-67 expression levels were evaluated in primary pterygium ( n = 35) and recurrent pterygium ( n = 32) tissue samples and compared with normal conjunctiva ( n = 30) tissue samples. In addition, recurrent pterygiums were divided into three groups based on recurrence time, and their p53, Bcl-2, and Ki-67 expression levels were compared. Results: The results show that p53, Bcl-2, and Ki-67 expression levels were significantly higher in the pterygium tissue samples as compared to the control group ( p < 0.001, p < 0.001, and p < 0.001, respectively). When primary and recurrent pterygium tissues were compared, bcl-2 expression was higher in recurrent pterygium tissue samples ( p = 0.003). However, when Ki-67 and p53 expression levels were evaluated, no significant difference was found between primary and recurrent pterygium ( p = 0.215, p = 0.321, respectively). Also, p53 and Ki-67 expression were correlated in pterygium tissue samples, and Bcl-2 expression was significantly higher in pterygium that recurrence in the first 6 months after surgery. There was no difference between groups 1, 2, and 3 in terms of p53 and Ki-67 expression. Conclusion: Antiapoptotic mechanisms and proliferation play an important role in the etiopathogenesis of pterygium. Furthermore, Bcl-2 expression may be important in pterygium recurrence.
Artificial intelligence–based morphological fingerprinting of megakaryocytes: a new tool for assessing disease in MPN patients
Authors: Sirinukunwattana Korsuk , Aberdeen Alan , Theissen Helen , Sousos Nikolaos , Psaila Bethan , Mead Adam J. , Turner Gareth D. H. , Rees Gabrielle , Rittscher Jens , Royston Daniel 
Published: July 2020

Abstract
Accurate diagnosis and classification of myeloproliferative neoplasms (MPNs) requires integration of clinical, morphological, and genetic findings. Despite major advances in our understanding of the molecular and genetic basis of MPNs, the morphological assessment of bone marrow trephines (BMT) is critical in differentiating MPN subtypes and their reactive mimics. However, morphological assessment is heavily constrained by a reliance on subjective, qualitative, and poorly reproducible criteria. To improve the morphological assessment of MPNs, we have developed a machine learning approach for the automated identification, quantitative analysis, and abstract representation of megakaryocyte features using reactive/nonneoplastic BMT samples (n = 43) and those from patients with established diagnoses of essential thrombocythemia (n = 45), polycythemia vera (n = 18), or myelofibrosis (n = 25). We describe the application of an automated workflow for the identification and delineation of relevant histological features from routinely prepared BMTs. Subsequent analysis enabled the tissue diagnosis of MPN with a high predictive accuracy (area under the curve = 0.95) and revealed clear evidence of the potential to discriminate between important MPN subtypes. Our method of visually representing abstracted megakaryocyte features in the context of analyzed patient cohorts facilitates the interpretation and monitoring of samples in a manner that is beyond conventional approaches. The automated BMT phenotyping approach described here has significant potential as an adjunct to standard genetic and molecular testing in established or suspected MPN patients, either as part of the routine diagnostic pathway or in the assessment of disease progression/response to treatment.