bluuebunny/crossref_metadata_2025_split huggingface dataset:
A hotel room on Mars: quarantine and the psychological view from the virtual front line
Authors: Modini Matthew , Vrklevski Lil 
Published: September 2020

Objective: Because of the COVID-19 pandemic, the implementation of quarantine for returning travellers and the effect this has on people’s mental health has become a topical issue. This article briefly describes the historical context of quarantine, research around its impact on people’s well-being, and the experiences of a clinical psychologist providing support to people in quarantine. Conclusions: Mental health professionals are in a unique position to assist people in quarantine, both in terms of counselling and ongoing research.
Problematic internet use: A scoping review – longitudinal research on a contemporary social problem, 2006–2017
Authors: Dahl Daniel , Bergmark Karin Helmersson 
Published: September 2020

Background and aims: Problematic internet use (PIU), and kindred concepts such as internet addiction (IA), make up a growing research field, partly due to the suggested inclusion of internet gaming disorder in a future DSM-6 as well as the fact that gaming disorder is on its way to being included in the ICD-11. Conclusions from research are far from unified. This study aims to synthesise the research field of problematic internet use/internet addiction/gaming disorder, with a focus on the reporting of prevalence and change. Methods: Longitudinal studies of PIU/IA formed the basis for a scoping review. Systematic searches of Web of Science, Scopus and Proquest, for peer-reviewed and published articles based on empirical data collected at a minimum of two time points for studies, and with an end point set at 2017, led to the inclusion of 97 studies. Endnote X7 was used to organise the results and NVivo 11 was used for synthesising the results. Results: Analyses focused on prevalence and change. Findings show variation among measures and prevalence as well as in reported outcomes relating to social life and other problems. Most studies reported relations between PIU/IA and other problems in life, but no specific time order could be established. Furthermore, many studies did not present data on prevalence or change even though using a longitudinal survey design. Discussion and conclusions: In summary, the research field is plagued by a lack of consensus and common understanding, regarding both measures, perceptions of the problem, and findings.
Intranodal lymphangio-embolisation as treatment for lymphocele after kidney transplantation: A case report
Authors: Lim Ee Jean , Aslim Edwin Jonathan , Lee Fang Jann , Gan Valerie Huei Li 
Published: September 2020

Introduction and objectives: The rate of symptomatic lymphoceles requiring intervention after renal transplantation is reported to be only 5.6%. Controversies prevail in the current literature regarding the management of symptomatic lymphoceles post renal transplantation, with no established algorithm. The creation of a peritoneal window, frequently performed laparoscopically, is deemed the gold standard for management. We herin report the case of a lymphocele post renal transplant treated minimally invasively with intranodal lymphangio-embolisation, with a review of the current literature of this uncommon procedure. Methods: This was a retrospective review of this patient’s electronic medical records. Results: We present a 43-year-old male with end-stage kidney disease secondary to chronic glomerulonephritis, having been on hemodialysis for seven years. He underwent a deceased donor dual kidney transplant, complicated postoperatively by renal vein thrombosis in one of the grafts, resulting in early graft nephrectomy as well as a distal ureterovesical leak requiring reimplantation. On re-implantation on postoperative day 16, he was noted to have a persistent high drain ouput with a normal drain fluid creatinine. A right intranodal lymphagiogram was performed, and this demonstrated an active lymph leak around the transplanted kidney. A 33% glue (N-butyl cyanoacrylate)-Lipodiol infusion was then injected at a rate of 0.2 mL/min intranodally under fluoroscopic guidance. The patient underwent another repeat embolisation five days later for a residual lymph leak with satisfactory results. Drain output subsequently decreased, and the drain was removed. Conclusions: This case suggests that intranodal lymphangiography and embolisation may not only be a diagnostic tool but can be considered as an effective, minimally invasive and safe method for the treatment of lymphoceles after kidney transplantation.
Different types of low back pain in relation to pre- and post-natal maternal depressive symptoms
Authors: Long Gong , Yao Zhang Yao , Na Yang , Ping Yi , Wei Sun , Mingsheng Tan 
Published: September 2020

Abstract
Background
Low back pain (LBP) is a common musculoskeletal problem during pregnancy, with an estimated prevalence ranging from 30–78% (Mota MJ et al. J Back Musculoskelet Rehabil 28(2):351-7,2015 and Abebe E et al. J Med Sc Tech 3(3). 37-44,2014). Women reporting LBP are at increased risk of developing perinatal depression. Pregnancy-related LBP is highly heterogeneous and can be divided into lumbar pain (LP), posterior pelvic pain (PPP), and combined pain (CP). Therefore, the purpose of this study was to investigate the associations between LBP and perinatal depressive symptoms.

Methods
This was a retrospective case-control study conducted from January 2016 to April 2019. A total of 484 pregnant women were enrolled in this study: a case group of 242 pregnant women who were diagnosed with LBP and an age-matched control group of 242 pregnant women without LBP. The Edinburgh Postnatal Depression Scale (EPDS), LBP characteristics, and questionnaires about pregnancy that included demographic, parity, work, comorbidity, and previous pregnancy data were completed and compared between the case group and the control group.

Results
A total of 68 of 242 (28.1%) women experienced PPP, 142 (58.7%) had lumbar pain(LP), and 32 (13.2%) had combined pain. Furthermore, 26.5% of women with prenatal depression in the LP subgroup remained depressed 6 months postnatally, while the percentages for women in the PPP subgroup and CP subgroup were just 10.6% and 15.6%, respectively. The percentage of women who recovered anytime between delivery and six months postnatally in the PPP subgroup was significantly higher than that in the LP subgroup (31.7% vs. 14.7%, P < 0.001).

Conclusions
There is a difference in the prevalence of prenatal, postnatal, and perinatal depressive symptoms among pregnant women with different types of LBP. It is necessary to screen prenatal and postnatal depression separately and differentiate the types of LBP during pregnancy. Attention to these factors may help to outline better management strategies to improve maternal health.
Assessment of the effect of platelet rich plasma on the healing of operated sacrococcygeal pilonidal sinus by lay-open technique: a randomized clinical trial
Authors: Gohar Mohamed M. , Ali Reda F. , Ismail Khaled A. , Ismail Taha A. , Nosair Nahla A. 
Published: September 2020

Abstract
Background
Sacrococcygeal pilonidal sinus disease (PSD) is an infection of the skin and subcutaneous tissue at the upper part of the natal cleft of the buttocks. Excision and healing by granulation “lay-open” method is still more preferable than other methods of midline closure or using flaps but the healing time is lengthy. The present study was performed to assess the healing promotion effect of platelet-rich plasma (PRP) on the pilonidal sinus wounds treated by the lay-open method.

Methods
One hundred patients suffering from PSD were randomly divided into two groups, they were treated by the lay-open method, at General surgery department, Kafr El-Sheik University hospital, Egypt, during the period from December 2018 to December 2019. Group (A) was adopted the regular dressing postoperatively, while group (B) was treated with PRP injection into the wound at 4 and 12 postoperative days.

Results
Accelerated rate of wound healing was detected in group (B) in day 10, with a significant difference detected in days 15, 20, 25 and 30 postoperative, with a mean time of complete healing 45 ± 2.6 days in group B, while it was 57 ± 2.4 days in group A with a p-value of 0.001 which indicates considerable effect in the treated group.

Conclusions
PRP injection is an effective new technique in accelerating the healing of pilonidal wound after surgery, with a significant decrease in post-operative pain, complications and an early return to work.

Trial registration
retrospectively registered. Trial registration number: 12/35/1016 issued on December 2018 from the Institution Review Board at Kafr El Sheikh University. ClinicalTrials.gov identifier: NCT04430413
Autophagic flux inhibition enhances cytotoxicity of the receptor tyrosine kinase inhibitor ponatinib
Authors: Corallo Diana , Pastorino Fabio , Pantile Marcella , Mariotto Elena , Caicci Federico , Viola Giampietro , Ponzoni Mirco , Tonini Gian Paolo , Aveic Sanja 
Published: September 2020

AbstractBackgroundDespite reported advances, acquired resistance to tyrosine kinase inhibitors still represents a serious problem in successful cancer treatment. Among this class of drugs, ponatinib (PON) has been shown to have notable long-term efficacy, although its cytotoxicity might be hampered by autophagy. In this study, we examined the likelihood of PON resistance evolution in neuroblastoma and assessed the extent to which autophagy might provide survival advantages to tumor cells.MethodsThe effects of PON in inducing autophagy were determined both in vitro, using SK-N-BE(2), SH-SY5Y, and IMR-32 human neuroblastoma cell lines, and in vivo, using zebrafish and mouse models. Single and combined treatments with chloroquine (CQ)—a blocking agent of lysosomal metabolism and autophagic flux—and PON were conducted, and the effects on cell viability were determined using metabolic and immunohistochemical assays. The activation of the autophagic flux was analyzed through immunoblot and protein arrays, immunofluorescence, and transmission electron microscopy. Combination therapy with PON and CQ was tested in a clinically relevant neuroblastoma mouse model.ResultsOur results confirm that, in neuroblastoma cells and wild-type zebrafish embryos, PON induces the accumulation of autophagy vesicles—a sign of autophagy activation. Inhibition of autophagic flux by CQ restores the cytotoxic potential of PON, thus attributing to autophagy a cytoprotective nature. In mice, the use of CQ as adjuvant therapy significantly improves the anti-tumor effects obtained by PON, leading to ulterior reduction of tumor masses.ConclusionsTogether, these findings support the importance of autophagy monitoring in the treatment protocols that foresee PON administration, as this may predict drug resistance acquisition. The findings also establish the potential for combined use of CQ and PON, paving the way for their consideration in upcoming treatment protocols against neuroblastoma.
Dirofilaria immitis in wolves recolonizing northern Italy: are wolves competent hosts?
Authors: Moroni Barbara , Rossi Luca , Meneguz Pier Giuseppe , Orusa Riccardo , Zoppi Simona , Robetto Serena , Marucco Francesca , Tizzani Paolo 
Published: September 2020

AbstractBackgroundWild carnivores such as the grey wolf (Canis lupus), red fox (Vulpes vulpes) and golden jackal (Canis aureus) are recognized hosts ofDirofilaria immitis. However, few studies have focused on their actual role in the epidemiology of heartworm infection. This study describes the prevalence and distribution ofD. immitisin wolves in a heartworm-endemic area in northern Italy where wolves have recently returned after long-time eradication, and investigates the fertility status of the collected adult nematodes.MethodsIn the frame of a long-term wolf monitoring programme in northwestern Italy, 210 wolf carcasses from four provinces were inspected for the presence of filarioid nematodes in the right heart and pulmonary arteries. Female heartworms were measured, and their uterine content analyzed according to a previously described “embryogram” technique.ResultsThree wolves, all originating from a single province (Alessandria), were positive forD. immitis(1.42%, 95% CI: 0.48–4.11%, in the whole study area; 13.6%, 95% CI: 4.7–33.3%, limited to the single province from which infected wolves originated). Mean intensity was 5 worms (range: 3–7) and the female worms measured 21–28 cm in length. Six out of 9 female worms harbored uterine microfilariae: 5 were classified as gravid; 1 showed a “discontinuous gradient”; and 3 were non-gravid.ConclusionsThe present data show that heartworm infection is already prevalent in wolves that have recolonized the known heartworm-endemic area. Based on “embryogram” results, wolves were shown suitable heartworm hosts. Interestingly, investigated wolves appeared similarly exposed to heartworm infection as sympatric unprotected dogs (owned dogs that have never received any heartworm prevention treatment) sampled at the beginning of the wolf return process.
Protocol for comparing two training approaches for primary care professionals implementing the Safe Environment for Every Kid (SEEK) model
Authors: Dubowitz Howard , Saldana Lisa , Magder Laurence A. , Palinkas Lawrence A. , Landsverk John A. , Belanger Rose L. , Nwosu Ugonna S. 
Published: September 2020

Abstract
Background
Child maltreatment (CM) is a major public health problem, affecting many lives, in the short and long term, and costing individuals, families, and society dearly. There is a need for broad implementation of evidence-based preventive interventions, such as the Safe Environment for Every Kid (SEEK) model, developed for pediatric primary care. Primary care offers an excellent opportunity to help address prevalent psychosocial problems (e.g., parental depression) that are risk factors for CM. By addressing such problems, SEEK can strengthen families and support parents; promote children’s health, development, and safety; help prevent CM; and benefit the health of the US population. This study will examine intervention strategies for optimizing SEEK’s adoption, implementation, and sustainment, and its effectiveness in preventing CM.
Despite strong evidence from two federally funded randomized controlled trials, SEEK has not been widely adopted. The goal of this study is to examine technology-driven implementation strategies to scale-up SEEK—in pediatric and family medicine primary care settings. The aims are to (1) evaluate the effectiveness of training strategies on SEEK’s implementation in primary care practices, (2) evaluate barriers and facilitators to successful implementation and sustainment of SEEK, and (3) examine the model’s effectiveness in preventing CM and the economic costs of implementing SEEK.

Methods
This randomized type III hybrid mixed methods design will examine how advances in medical training can bolster SEEK’s adoption and implementation in pediatric and family medicine practices in different regions of the USA. These are independent online training and in-depth structured training via a quality improvement project, approved by the American Boards of Pediatrics and of Family Medicine. We will also evaluate SEEKonline, software that assists primary care practitioners implement the model, and a “Traditional” paper and pencil strategy for their impact on implementation. The study uses the EPIS framework and the Universal Stages of Implementation Completion, quantitative measures, qualitative interviews, and data abstracted from electronic health records.

Discussion
The knowledge gained should improve pediatric primary care to better address prevalent social determinants of health, benefiting many children and families. The outcomes should enhance the field of implementation science and guide future interventions in primary care.

Trial registration
NCT03642327, Clinical Trials, registered August 21, 2018.
Randomised clinical trial on 7-days-a-week postoperative radiotherapy vs. concurrent postoperative radio-chemotherapy in locally advanced cancer of the oral cavity/oropharynx
Authors: Wozniak Grzegorz , Misiołek Maciej , Idasiak Adam , Dębosz-Suwińska Iwona , Jaworska Magdalena , Bal Wieslaw , Maciejewski Boguslaw , Miszczyk Leszek , Składowski Krzysztof , Suwinski Rafal 
Published: September 2020

Objective: To compare the efficacy and tolerance of 7-days-a-week accelerated postoperative radiotherapy (p-CAIR) vs postoperative radio-chemotherapy (p-RTCT) Methods: Between September 2007 and October 2013, 111 patients were enrolled and randomly assigned to receive 63 Gy in 1.8 Gy fractions 7-days-a-week (n = 57, p-CAIR) or 63 Gy in 1.8 Gy fractions 5-days-a-week with concurrent cisplatin 80–100 mg per square meter of body-surface area on days 1, 22 and 43 of the radiotherapy course (p-RTCT). It represents approximately 40% of the intended trial size, that was closed prematurely due to slowing accrual. Only high-risk patients with squamous cell cancer of the oropharynx/oral cavity, considered fit for concurrent treatment were enrolled. Results: The rate of locoregional control (LRC) did not differ significantly between treatment arms (p = 0.18, HR = 0.56), 5 year LRC tended, however, to favour p-RTCT (81%) vs p-CAIR (62%). There was no difference in overall survival between treatment arms (p = 0.90, HR = 1.03). The incidence and severity of acute mucosal reactions and late reactions did not differ significantly between treatment arms. Haematological toxicity of p-RTCT was, however, considerably increased compared to p-CAIR Conclusion: Concurrent postoperative RTCT tended to improve locoregional control rate as compared to p-CAIR. This, however, did not transferred into improved overall survival. Postoperative RTCT was associated with a substantial increase in haematological toxicity that negatively affected treatment compliance in this arm. Advances in knowledge: To our knowledge, this is the first trial that compares accelerated radiotherapy and radio-chemotherapy in postoperative treatment for oralcavity/oropharyngeal cancer
Features of the initial stage of formation of fast coronal mass ejection on February 25, 2014
Authors: Eselevich Viktor , Eselevich Maxim 
Published: September 2020

We have analyzed the fast coronal mass ejection (CME) that occurred on February 25, 2014. The analysis is based on images taken in the 131, 211, 304, and 1700 Å UV channels of the SDO/AIA instrument and from observations obtained in the Hα line (6562.8 Å) with the telescopes of the Teide and Big Bear Observatories.
The February 25, 2014 CME is associated with the ejection and subsequent explosive expansion of the magnetic flux rope, which appeared near the solar surface presumably due to the tether-cutting magnetic reconnection.
The impulse of full pressure (thermal plus magnetic) resulting from such an “explosion” acts on the overlying coronal arcades, causing them to merge and form an accelerated moving frontal structure of the CME. This pressure impulse also generates a blast collisional shock wave ahead of the CME, whose velocity decreases rapidly with distance. At large distances R>7R₀ (R₀ is the solar radius) from the center of the Sun in front of the CME, a shock wave of another type is formed — a “piston” collisional shock wave whose velocity varies little with distance.
At R≥15R₀, there is a transition from a collisional to a collisionless shock wave.
A tragédia que a Copa legou ao Brasil – as Jornadas de Junho e a efervescente anticorrupção
Authors: Sander Damo Arlei 
Published: September 2020

Este texto explora as conexões entre os megaeventos esportivos realizados no Brasil em 2014 e 2016, em particular a Copa das Confederações, de 2013, e os megaprotestos que ficaram conhecidos como Jornadas de Junho. As publicações produzidas logo após essas manifestações enfatizaram a participação de coletivos de esquerda, aqui tratados como insurgentes, e a multiplicidade de pautas. Investigações a posteriori, com as quais procuro dialogar, tendem a enfatizar a emergência de pautas conservadoras e antidemocráticas, aqui tratadas como intransigentes. Acompanho aqueles textos que enfatizam o discurso anticorrupção como o principal destaque das Jornadas de Junho, em torno do qual se produziu uma espécie de consenso improvável, porque aproximou e confundiu insurgentes e intransigentes. O objetivo principal é mostrar como a preparação para os megaeventos e, particularmente, as alianças entre dirigentes esportivos, grandes empreiteiras e políticos de diferentes matizes, incluindo-se Lula e Dilma, mobilizaram críticas generalizadas em relação à gestão do Estado. Uso o conceito de escala para mostrar como principiaram as manifestações de 2013, antes das Jornadas de Junho, e de como elas adquiriram e perderam tração. Um dos eventos centrais nesse processo, tanto de mudança de escala como de torção ideológica, foi a aparição acompanhada de vaias à presidente Dilma ao lado do então presidente da FIFA, Joseph Blatter, quando da abertura da Copa das Confederações.
Foucault e o neoliberalismo de subjetividades precárias: Incidências na escola pública brasileira
Authors: Carvalho Alexandre Filordi de 
Published: September 2020

O artigo investiga como o neoliberalismo é uma arte contemporânea de produzir e de governar subjetividades precárias. A hipótese é a de que a arte de governar neoliberal, ao compor o que Foucault denominou de dispositivo de segurança, atua diretamente precarizando a escola pública. O intuito dessa ação é o de fazer da potência subjetiva matéria de adaptação para a precarização. Logo, a escola pública precarizada funcionaria como instituição que adéqua seus sujeitos às demandas neoliberais precarizadoras. O artigo usa dados econômicos para poder comprovar tal perspectiva. Ao cabo, o artigo defende ser urgente a escola pública recobrar a função de educar contra a precarização, afirmando-se como espaço público, laico e gratuito de formação para a denúncia e a resistência à arte de governo neoliberal.