bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of Chronic Urticaria
Authors: Iftikhar Usma , Hasan Shawana Sharif 
Published: March 2020

The management of urticaria, although complex, relies on two postulates:
•	Recognition and eradication of the triggering factor(s)
•	Provision of symptomatic relief

Recognition and eradication of the triggering factors(s)
Factors known are drugs, food, infections, and physical stimuli.
Drugs: Analgesics and NSAIDs can exacerbate already present urticaria and are also recognized triggers of new-onset urticaria.2 When suspected, they should be withdrawn entirely or can be replaced. ACE inhibitors can cause angioedema.
Eradication of infectious agents
Infections and infestations should be treated where suspected, including infections of the GI tract e.g., H Pylori associated gastritis3, nasopharyngeal bacterial infections, and intestinal worms.8
Management of diet
The allergens in food need to be avoided if a patient has type I hypersensitivity to any one of these allergens. Pseudo-allergic reactions5 which are not IgE mediated have been described for organic foods and food additives.9-13
Physical stimuli
They are usually recognized and controlled, e.g., in chronic pressure urticaria patients are advised to use bags with a wide handle and similarly, in symptomatic dermographism, simple avoidance of friction can give relief from symptoms.15
Symptomatic therapy
One of the objectives of symptomatic therapy is to mask the effects of histamine, platelet-activating factor, and other mast cell mediators. Histamine plays a primary role in inducing the symptoms associated with urticaria. The activation of receptors on endothelial cells by histamine results in wheals whereas this histamine receptor activation on sensory nerves results in itching. Different guidelines have been proposed for managing chronic urticaria including the EACCI [5] and BSACI [4].
INKONSISTENSI KEBIJAKAN ENERGI DI INDONESIA: KAITANNYA TERHADAP PEMBERLAKUAN STANDAR EMISI GAS BUANG EURO 4
Authors: Efendi Agus , Karunian Alia Yofira , Arsani Ni Luh Putu Chintya 
Published: March 2020

Disahkannya Perpres No. 191 Tahun 2014 tentang Penyediaan, Pendistribusian dan Harga Jual Eceran Bahan Bakar Minyak pada 31 Desember 2014 lalu menandakan komitmen Indonesia dalam mengurangi penggunaan energi tak ramah lingkungan. Perpres No. 191 Tahun 2014 ini membatasi pendistribusian Premium untuk wilayah yang menghasilkan gas buang kendaraan bermotor dengan jumlah besar seperti Jawa dan Bali. Namun, pada 24 Mei 2018 lalu, Presiden Jokowi mengesahkan Perpres No. 43 Tahun 2018 yang kembali mewajibkan pendistribusian Premium di wilayah Jawa dan Bali. Rencana ini bertentangan dengan komitmen Indonesia dalam mengimplementasikan baku mutu emisi gas buang Euro 4 yang diadopsi melalui Permen LH No. 20 Tahun 2017 tentang Baku Mutu Emisi Gas Buang Kendaraan Bermotor Tipe Baru Kategori M, N, dan O. Artikel ini mengaplikasikan metode penelitian audit kebijakan. Simpulan dari artikel ini adalah evidence-based policy making tidak diimplementasikan dalam perumusan Perpres No. 43 Tahun 2018. Meskipun bukti ilmiah menunjukkan bahwa Premium tidak memenuhi standar Euro 4, Pemerintah tetap bersikeras mewajibkan kembali pendistribusian Premium di wilayah Jawa dan Bali.
ADAPTASI PERUBAHAN IKLIM DAN KETAHANAN PANGAN: TELAAH INISIATIF DAN KEBIJAKAN
Authors: Perdinan Perdinan , Atmaja Tri , Adi Ryco F , Estiningtyas Woro 
Published: March 2020

Dalam dua dekade terakhir, berbagai program intensifikasi penggunaan sarana produksi pertanian (misal: bantuan benih, pupuk bersubsidi, pupuk organik, dan perbaikan irigasi) telah berdampak terhadap peningkatan produksi beras nasional. Di balik keberhasilan program tersebut, fluktuasi kondisi iklim memberikan tantangan dalam mempertahankan stabilitas produksi nasional. Kondisi tersebut dapat diperparah dengan adanya potensi dampak negatif perubahan iklim yang berakibat pada penurunan produktivitas ataupun peningkatan serangan hama dan penyakit. Ancaman lainnya adalah peningkatan fenomena iklim ekstrem yang dapat menyebabkan bencana banjir dan kekeringan, sehingga berimplikasi pada gagal panen ataupun gagal tanam. Memperhatikan kondisi tersebut, tulisan ini membahas berbagai inisiatif adaptasi yang dilakukan melalui langkah praktis dan didorong oleh regulasi yang dikeluarkan pemerintah Indonesia. Praktik adaptasi dilakukan melalui insiatif mandiri berdasarkan kearifan lokal maupun bantuan pemerintah. Iniastif pemerintah terkait adaptasi dilakukan melalui Pedoman Umum Langkah-Langkah Adaptasi Perubahan Iklim (Pedum) dan langkah praktis dalam strategi budidaya yang responsif terhadap perubahan iklim.
Molecular docking studies of N-substituted 4-methoxy-6-oxo-1-aryl-pyridazine-3-carboxamide derivatives as potential modulators of glutamate receptors
Authors: Avdeeva Natalia V. , Severina Hanna I. , Georgiyants Victoriya A. , Kovalenko Sergiy M. , Yarcev Artem I. , Prohoda Svetlana N. 
Published: March 2020

Introduction: The virtual target-oriented screening is a necessary stage of modern drug-design. In the present study, the affinity of pyridazine derivatives for the most promising antiparkinsonian biotargets – I–III groups of metabotropic and ionotropic NMDA-glutamate receptors – was evaluated.
Materials and methods: Docking of the studied ligands to the active sites of biotargets – mGluR5, mGluR3, mGluR8, NMDA GluN2B – was performed using AutoDockVina. Base of the preparation of ligands and proteins – AutoDock­Tools-1.5.6. A Discovery Studio Visualizer 2017/R2 was used to visualize the interpretation of the results.
Results and discussion: A high degree of the affinity is predicted for group III of the metabotropic mGlu8 receptors – binding energy from -5.0 to -8.7 kcal/mol, compared to -6.1 kcal/mol of that of the reference drug (L-AP4), as well as for the ionotropic NMDA GluN2B receptors –binding energy from -8.7 to -11.6 kcal/mol, compared to -11.3 kcal/mol of that of ifenprodil.
Conclusion: The prospects of the searching for glutamate receptor modulators in a number of n-substituted 4-methoxy-6-oxo-1-aryl-pyridazine-3-carboxamide derivatives are proved. Some aspects of the structure-affinity relationship are discussed.
The Modularity of Special Cycles on Orthogonal Shimura Varieties over Totally Real Fields under the Beilinson–Bloch Conjecture
Authors: Maeda Yota 
Published: March 2020

AbstractWe study special cycles on a Shimura variety of orthogonal type over a totally real field of degree d associated with a quadratic form in $n+2$ variables whose signature is $(n,2)$ at e real places and $(n+2,0)$ at the remaining $d-e$ real places for $1\leq e <d$. Recently, these cycles were constructed by Kudla and Rosu–Yott, and they proved that the generating series of special cycles in the cohomology group is a Hilbert-Siegel modular form of half integral weight. We prove that, assuming the Beilinson–Bloch conjecture on the injectivity of the higher Abel–Jacobi map, the generating series of special cycles of codimension er in the Chow group is a Hilbert–Siegel modular form of genus r and weight $1+n/2$. Our result is a generalization of Kudla’s modularity conjecture, solved by Yuan–Zhang–Zhang unconditionally when $e=1$.
Shipborne MAX-DOAS measurements for validation of TROPOMI NO2 products
Authors: Wang Ping , Piters Ankie , van Geffen Jos , Tuinder Olaf , Stammes Piet , Kinne Stefan 
Published: March 2020

Abstract. Tropospheric NO2 and stratospheric NO2 vertical column densities are important TROPOspheric Monitoring Instrument (TROPOMI) data products.
In order to validate the
TROPOMI NO2 products, KNMI Multi-AXis Differential Optical Absorption Spectroscopy (MAX-DOAS) instruments have measured NO2 on ship cruises over the Atlantic
and the Pacific oceans. The MAX-DOAS instruments have participated in five cruises on board RV Sonne (in 2017 and 2019)
and RV Maria S. Merian (in 2018). The MAX-DOAS measurements were acquired over 7 months and spanned
about 90∘ in latitude and 300∘ in longitude.
During the cruises aerosol measurements from Microtops sun photometers were also taken.
The MAX-DOAS measured stratospheric NO2 columns between
1.5×1015 and 3.5×1015 molec cm−2
and tropospheric NO2 up to 0.6×1015 molec cm−2.
The MAX-DOAS stratospheric NO2 vertical column densities have been compared with
TROPOMI stratospheric NO2 vertical column densities
and the stratospheric NO2 vertical column densities
simulated by the global chemistry Transport Model, version 5, Massively Parallel model (TM5-MP). Good correlation is found between the MAX-DOAS and TROPOMI and
TM5 stratospheric NO2 vertical column densities, with a correlation coefficient of 0.93 or larger. The TROPOMI and TM5
stratospheric NO2 vertical column densities are about 0.4×1015 molec cm−2 (19 %) higher than
the MAX-DOAS measurements.
The TROPOMI tropospheric NO2 also has good agreement with the MAX-DOAS measurements. The
tropospheric NO2 vertical column density is as low as 0.5×1015 molec cm−2 over remote oceans.
Is Alexa My Neighbor?
Authors: Ammon Laura , Reed Randall 
Published: March 2020

ABSTRACT
The advent of home artificial intelligence devices such as Amazon Echo (“Alexa”), Google Home, and Apple’s Siri represent a first incursion of artificial intelligence into the homes of Americans. It is predicted that A.I.s will continue to become more intelligent over time and even begin to develop unique personalities in response to their users. Might such A.I.s be perceived as religious persons? And if so, what strategies might the church use for their inclusion? In this article we will examine two examples in an attempt to look at the strategies that Christian churches have used to justify the inclusion of such persons: the sixteenth-century debate in the Catholic Church about the religious status of Native Americans, and twentieth- (and twenty-first-) century debates in Protestant churches about the religious status of LGBT+ people. In both these examples, the church designated peoples in these categories as being outside the religious sphere of salvation and then came to accept and in some cases celebrate these groups as part of God’s plan. We will then suggest the way that these two examples may eventually act as precursors to a future debate over the religious status of artificial intelligence.
Reviewer Acknowledgements for English Linguistics Research, Vol. 9, No. 1
Authors: Su Camille 
Published: March 2020

English Linguistics Research (ELR) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether ELR publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue. Reviewers for Volume 9, Number 1 Alina Andreea Dragoescu Urlica, University of Life Sciences, RomaniaHülya Tuncer, Çukurova University, TurkeyKate Short-Meyerson, University of Wisconsin Oshkosh, USAKazeem K. Olaniyan, Ladoke Akintola University of Technology, NigeriaLi-ping Chang, National Taipei College of Business, TaiwanOmer Elsheikh Hago Elmahdi, Taibah Universit, Saudi ArabiaSawsan M.A. Ahmed, Taif University, Saudi ArabiaWin Whelan, St. Bonaventure University, USAZeineb Ayachi Ben Abdallah, Higher Institute of Human Sciences Jendouba, Tunisia Best Regards,Camille SuEditorial Assistant, English Linguistics ResearchSciedu Press*************************************Add: 9140 Leslie St. Suite 110, Beaver Creek, Ontario, L4B 0A9, CanadaTel: 1-416-479-0028 ext. 210Fax: 1-416-642-8548E-mail1: elr@sciedupress.com E-mail2: elr@sciedupress.org Website: http://elr.sciedupress.com
Pengaruh sumber karbon terhadap produksi bioplastik polihidroksialkanoat (PHA) dengan ralstonia eutropha
Authors: Aznury Martha , Setiadi Tjandra , Pancoro Adi 
Published: March 2020

Bioplastic Polyhidroxyalknoate (PHA) is a polyester type bioplastic with physicochemical properties resemble to those of polypropilen from petroleum. PHA production was investigated to determine the effect of carbon source on the fermentation process by Ralstonia eutropha. Specifically, Ralstonia eutropha was cultivated in a batch bioreactor to show the dynamics of P(3HB-co-3HV) copolymer production from glucose or fructose as C source. In adition, the effect of volatile fatty acids addition, as stimulator to the copolymer production, was also studied. The operating conditions in a 7 L bioreactor were at temperature 30 oC and pH 7.0. The concentration of carbon source glucose or fructose was 40 g/L, and after 20 hour fermentation, volatile fatty acids were added. With volatile fatty acids addition, the resulting fructose fermentation had PHA content of 32.78%, in which the HV percentage was 11.78%. Meanwhile, the fermentation of glucose, stimulated by volatile fatty acids, gave PHA as much as 20.19% with HV percentage of 8.71%. Therefore,, the Ralstonia eutropha fermentation of fructose as the carbon source gave a higher yield than glucose. Keywords: Volatil Fatty Acid, Fructose, Glucose, PHA, P(3HB-co-3HV), Ralstonia eutropha AbstrakBioplastik polihidroksialkanoat (PHA) adalah bioplastik dari kelompok poliester dengan sifat fisikokimia mirip dengan plastik polipropilen dari minyak bumi. Penelitian ini bertujuan untuk mempelajari pengaruh sumber karbon terhadap poduksi PHA yang dilakukan dengan proses fermentasi menggunakan Ralstonia eutropha. Ralstonia eutropha dikultivasi dalam bioreaktor batch untuk mempelajari dinamika produksi kopolimer P(3HB-co-3HV) dari sumber karbon glukosa atau fruktosa, serta mempelajari pengaruh sumber stimulator asam lemak volatil. Kondisi operasional fermentasi menggunakan bioreaktor 7 L adalah pada temperatur 30 oC dan pH 7. Konsentrasi sumber karbon glukosa atau fruktosa yang digunakan adalah 40 gr/L, dan setelah 20 jam fermentasi ditambahkan asam lemak volatil yang berfungsi sebagai stimulator dalam produksi P(3HB-co-3HV). Panen sel Ralstonia eutropha dilakukan setelah 60 jam. Hasil penelitian menunjukkan fermentasi Ralstonia eutropha dengan substrat fruktosa dan asam lemak volatil sebagai stimulator mempunyai kandungan PHA sebesar 32,78%, dengan kadar HV 11,78%. Pada pemberian substrat glukosa dan asam lemak volatil menunjukkan kandungan PHA sebesar 20,19%, dengan kadar HV 8.71%. Jadi fermentasi Ralstonia eutropha dengan menggunakan substrat fruktosa memberikan yield yang lebih tinggi dibandingkan menggunakan substrat glukosa.Kata Kunci: Asam lemak volatil, fruktosa, glukosa, PHA, P(3HB-co-3HV), Ralstonia eutropha
Evaluating Mismatch Repair/Microsatellite Instability Status Using Cytology Effusion Specimens to Determine Eligibility for Immunotherapy
Authors: Jacobi Elizabeth M. , Landon Gene , Broaddus Russell R. , Roy-Chowdhuri Sinchita 
Published: March 2020

Context.—The approval of pembrolizumab for treatment of patients with microsatellite instability-high (MSI-H) or mismatch repair–deficient (dMMR) advanced cancers has led to increased requests for MSI and/or MMR immunoperoxidase (IPOX) testing. Diagnoses for patients with advanced-stage cancer are frequently made from cytology specimens.Objective.—To investigate the feasibility of using cell block (CB) preparations of effusions for MMR IPOX evaluation.Design.—Surgical pathology cases of colorectal and endometrial carcinomas with known MMR/MSI status and matched effusions with available CBs were identified. Cell block sections were evaluated for adequacy and stained with MMR IPOX (MSH2, MSH6, MLH1, and PMS2). The CBs were reviewed, the number of tumor cells quantified, and MMR IPOX was interpreted as retained, lost, suboptimal, or noncontributory.Results.—We identified 748 cases with MMR/MSI testing on surgical specimens having matched effusions. Of these, 131 cases (17.5%) had an available CB and 53 were deemed adequate for MMR IPOX staining. MMR IPOX results between effusion CBs and surgical pathology specimens were concordant in 45 of 53 (85%), inconclusive in 6 of 53 (11%), and discordant in 2 of 53 (4%) cases.Conclusions.—There was high concordance of MMR IPOX testing between cytologic and surgical specimens, with no false-positive and 2 false-negative CB results. Limited tumor cells, staining in cells indefinite as tumor, tumor staining heterogeneity, and lack of internal control staining were problematic in some cases. Our findings indicate that cytologic effusion specimens may be suitable substrates for MMR IPOX biomarker testing; however, inconclusive cases need to be interpreted with caution.
A psicopatologia na perspectiva de Carl Gustav Jung
Authors: Padua Elisângela Sousa Pimenta de , Serbena Carlos Augusto 
Published: March 2020

A psiquiatria psicodinâmica, normalmente associada à psicanálise, possui diversas abordagens teóricas dissidentes desta. Dentre elas, a mais expressiva é a Psicologia Analítica desenvolvida pelo psiquiatra suíço Carl Gustav Jung, cuja hipótese fundamental é o inconsciente coletivo. Isto possibilitou elaborar uma perspectiva psicogênica, simbólica e hermenêutica dos fenômenos psíquicos. Assim, o objetivo desta pesquisa é identificar as principais ideias, teorias e conceitos a respeito das psicopatologias segundo este autor. Para tal foi realizada uma pesquisa de levantamento bibliográfico das suas principais obras relacionadas ao tema. Foi possível delimitar dez critérios referentes às suas principais ideias e teorias. A partir destas constatações, conclui-se que as psicopatologias possuem sentido, significado e finalidade quando compreendidas simbolicamente e fazem parte do processo de individuação.
Classificação da Funcionalidade de idosos de um núcleo de maturescência: a relevância dos aspectos psicossociais.
Authors: Moser Auristela Duarte de Lima , Benicio Mariane , Santos Bárbara Cordeiro , Scharan Karoleen Oswald , Moser Ana Maria 
Published: March 2020

Buscando operacionalizar o conceito de funcionalidade, a Organização Mundial da Saúde publicou a Classificação Internacional de Funcionalidade, Incapacidade e Saúde (CIF), que possibilita o registro de perfis de funcionalidade, incapacidade e saúde e seus domínios relacionados. Objetivo. Conhecer o estado de funcionalidade dos participantes de um serviço de atenção ao idoso utilizando a CIF. Método. A amostra foi composta por 59 participantes, que responderam a dois questionários elaborados, com base na CIF, além do Miniexame do Estado Mental (MEEM). Os dados foram tratados no IBM SPSS Statistics 20. Resultados. Registrou-se idade média de 65,8 anos (± 7,5), prevalência de mulheres, indivíduos com alta escolaridade e com renda familiar de 8 salários mínimos ou mais. Pontuação igual ou superior a 25 pontos no MEEM foi alcançada por 89,8% da amostra. A maioria dos participantes nãoapresentou deficiência em Funções do Corpo nem dificuldade em Atividades e Participação e considerou seu ambiente como facilitador, o que permitiu inferir que tais sujeitos apresentaram bom estado de funcionalidade. Porém, os que o fizeram relataram dificuldades relativas às funções mentais e atividades relacionadas à cognição. A CIF mostrou-se um importante instrumento para acessar a saúde e seus estados relacionados possibilitando uma leitura das necessidades dos sujeitos, não apenas ressaltando as demandas biológicas, psicológicas e sociais, mas também indicando a interdependência entre as mesmas.
Efeito da supressão de pensamentos sobre alimentação no comportamento alimentar: uma revisão de literatura
Authors: Andrade Amanda Cristina , Lima de Oliveira João Paulo , Custódio Machado Hellen , Carvalho Bastos Sabrina 
Published: March 2020

A supressão do pensamento sobre a alimentação pode ser considerada um efeito colateral de dietas restritivas que influenciam o comportamento alimentar e o funcionamento cognitivo dos indivíduos. Neste contexto, este estudo visa sistematizar os dados relacionados com a supressão de pensamentos em indivíduos e o seu efeito no comportamento alimentar. Realizou-se uma revisão da literatura de artigos científicos publicados nas seguintes bases de dados: Scientific Eletronic Library Online (SciElo), Medical Literature Analisys and Retrivial System Online (MEDLINE), Scopus e Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS). A busca ocorreu utilizando os descritores: ''thought suppression'', ''food'', ''cravin'', ''food behavio'' e ''dietary restraint''. Os artigos foram selecionados em duas etapas e organizados com as informações: autor e ano de publicação, público-alvo, amostra, metodologia e principais resultados e conclusões. Os resultados apontam os reflexos negativos da influência da supressão do pensamento sobre o comportamento alimentar principalmente no gênero feminino, praticantes de dietas restritivas e indivíduos com excesso de peso e obesidade. Tais aspectos negativos envolvem episódios de compulsão alimentar, após um determinado tempo de restrição alimentar. Sendo assim, a supressão de pensamentos está fortemente associada ao desenvolvimento de compulsão alimentar e são necessários mais estudos que comprovem a eficácia na utilização de métodos como questionários validados para diagnóstico precoce e técnicas como o ''mildfulness'' e outras ainda pouco divulgadas que objetivam o desvio desses pensamentos.
Avós que coabitam e compartilham as tarefas parentais
Authors: Xavier Scremin Ana Luiza , Ross Campeol Ângela , Machado Freitas Ana Paula , Scapin Teixeira Karina , Rubin Rossato Pereira Caroline 
Published: March 2020

As famílias apresentam na contemporaneidade transformações em sua constituição e no desenvolvimento das funções parentais, em que associado à maior expectativa de vida dos idosos, os avós com frequência aparecem como importante rede de apoio para a organização familiar. O presente estudo objetivou conhecer a experiência de avós que vivem em famílias intergeracionais. De modo especial, buscou-se compreender a divisão de tarefas parentais entre pais e avós em relação às crianças da família. Participaram do estudo, quatro avós que coabitavam com um ou mais netos e ao menos um dos pais das crianças. As participantes responderam a um questionário de dados sociodemográficos, a uma entrevista individual e duas delas participaram de um grupo focal. A partir da análise dos dados, identificou-se que as avós referiram participar amplamente dos cuidados dos netos, contudo, houve diferenças entre as famílias em que apenas um dos pais estava presente e aquelas em que ambos faziam parte da família.
Symmetrical Hollenhorst Emboli with Branch Retinal Artery Occlusion
Authors: Mishra Sanjay Kumar , Kumar Ashok 
Published: March 2020

Purpose:
To report a rare phenomenon of symmetrical hollenhorst emboli with branch retinal artery occlusion in a middle aged male with sub-optimal visual recovery.

Case Description:
A 50 year old man with a history of being known case of diabetes mellitus since 07 years presented to the ophthalmic emergency with sudden, profound diminution of vision in right eye of 05 days duration. His best corrected visual acuity (BCVA) was 20/400 in right eye and 20/30 in left eye. Fundus examination of right eye revealed normal optic disc with two symmetrical yellowish, refractile cholesterol emboli (Hollenhorst plaques) in supero-tempora and inferotemporal branch of retinal artery. Emboli in supero-temporal retinal had lead to obstruction of artery with pale retina in its distribution and superior part of macula. Immediate treatment with tab acetazolamide 500mg stat, ocular massage alonwith paracentesis was done with no improvement in vision. Cardiology consultation revealed cardiac emboli on trans-esophageal echocardiography but normal carotid Doppler. Patient was treated with anticoagulant, antiplatelet therapy with no evidence of adverse cardiac or neurological event on follow-up for next 02 months with some improvement in BCVA to 20/200.

Conclusion:
Symmetrical hollenhorst emboli leading to BRAO is a rare phenomenon which requires immediate ophthalmological as well as cardiology management for preventing ocular morbidity as well as mortality in these patients.