bluuebunny/crossref_metadata_2025_split huggingface dataset:
Activity And Kinetics of α-Glucosidase Inhibition by Collagen Hydrolysate From Thunnus albacares Bone
Authors: Natsir H , Dali S , Arif A R , Sartika  , Leliani  
Published: November 2019

Abstract
Controlling of postprandial hyperglycemia using α-glucosidase inhibitors is one of the therapeutic approaches for the treatment of type 2 diabetes. Collagen hydrolysate, as an α-glucosidase inhibitor has not been reported. Therefore, This study intends to evaluate the activity and kinetics of inhibition of collagen hydrolysate against the α-glucosidase enzyme. Collagen hydrolysate was prepared from Thunnus albacares bone enzymatically using bacterial collagenase at hydrolysis times (0; 0.5; 1; 2; 3; 4; 5 and 6 h). The type of inhibition was determined by enzyme kinetics analysis. Collagen hydrolysate obtained at hydrolysis time of 1 h has the highest inhibitory activity of 24.47 %. Based on enzyme kinetics analysis, collagen hydrolysate showed a show a type of competitive inhibition. These results revealed that collagen hydrolysate has the potential as a natural antidiabetic in controlling blood glucose levels in type 2 diabetes.
Symbiont bacteria cultures from the red algae Eucheuma spinosum, isolation of bioactive proteins and their anticancer potential test
Authors: Ramadan R , Ahmad A , Marinda  , Natsir H , Karim A , Karim H 
Published: November 2019

Abstract
Red algae Eucheuma spinosum is one of marine organisms which have the potential bioactive protein. This research aimed to determine the protein concentration of red algae Eucheuma spinosum and to discover its potential as an anticancer agent. Protein was isolated from bacterial symbiont of red algae Eucheuma spinosum by buffer A with pH value 8.3. Protein crude extract was fractionated by adding ammonium sulphate with a saturation level of 0-20%, 20-40%, 40-60%, and 60-80%. The result was dialyzed using cellophane membrane. Lowry method with Bovine Serum Albumin (BSA) was used as the standard to determine the protein level. An anticancer preliminary test was conducted using Brine Shrimp Lethality Test (BSLT) method. The result showed that the protein concentration from crude extract of red algae Eucheuma spinosum was 33.325 mg/mL. The highest concentration that was obtained at fraction 0-20% is 32.145 mg/mL. The result of toxicity test using Brine Shrimp Lethality Test (BSLT) method at protein fraction of 20-40% has a very low LC50 value at <1000 µg/mL. Red algae protein fraction is potential to be developed as anticancer agent.
Isolation and Identification of Bioactive Proteins from Microsymbiont Algae Eucheuma cottonii and Their Potential as An Anticancer
Authors: Marinda  , Ahmad A , Yusriadi  , Arfah A R , Asmi N , Karim H 
Published: November 2019

Abstract
The isolation and identification of bioactive proteins from the microsymbiont algae Eucheuma cottoni from Laikang district of Takalar in South Sulawesi have been carried out. This study aimed to isolate and identify the bioactive proteins from microsymbiont algae E. cottonii and their potential as an anticancer. The experiment method includes the stages of extraction, fractionation, and dialysis. The obtained bioactive proteins were identified by determinating protein contents using the Lowry method. Furthermore, the preliminary anticancer test was conducted by testing Brine Shrimp Lethality Test (BSLT) method against shrimp larvae Artemia salina Leach. and the antimitotic test was also conducted against the sea urchin Tripneustes gratilla Linn. zygote cells. The result showed that the protein fraction of 40-60% saturation was the most toxic with LC50 with a value of 91.83 μg/mL and IC50 with a value of 74.13 μg/mL. This result suggested that the bioactive proteins of microsymbiont algae E. cottonii could be used as a potential anticancer agent.
Isolation and characterization of starch from the hump of kepok banana (Musa balbisiana. L) as a precursor of biodegradable polyurethane synthesis
Authors: Budirohmi A , Ahmad A , Firdaus  , Taba P , Tahir D 
Published: November 2019

Abstract
Starch from hump (Musa balbisiana L.) was isolated bythe maceration method. Bond characterization and determinationof gelatinization temperature, morphology, and particle size were conducted using Fourier Transform Infrared (FTIR), X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Differential Scanning Colorimetry (DSC), respectively. This isolation produced starch with a yield of 17.2%, amorphous phase portion 78.8%, particle size of 70 nm, and the starch gelatinization process occurred at 67.5°C. Based on these data, the obtained starch has high potential to be applied as a precursor to synthesize polyurethane biopolymers.
The role of acetone solvent in the reaction of 3-chloropropionyl- and 2-chloropropionyl-isothiocyanate with hydrazine
Authors: Firdausiah Syadza , Hasbullah Siti Aishah , Yamin Bohari M. 
Published: November 2019

Abstract
The reaction of 3-chloropropionylisothiocyanate with hydrazine did not give the expected bis(3-chloropropionylthioureido)hydrazine but instead 3-Chloro-N-[5,5-dimethyl-4-(4-oxo-5,6-dihydro-4H-[1,3]thiazin-2-yl)-4,5- dihydro-[1,3,4]thiadiazol-2-yl]-propionamide 2 was obtained with 23.56% yield. On the other hand 2-thiocyanatopropionylisothiocyanate undergoes crisscross cycloaddition leading to the formation of 3,3,7,7-Tetramethyl-tetrahydro-[1,2,4]triazolo[1,2-a][1,2,4]triazole-1,5-dithione 1 with 96.1% yield. The mechanisms involving the acetone solvent for both reactions are discussed. Both compounds were evaluated to their antioxidant activity using DPPH radical scavenging method. The results shows that compound 2 with EC50 > 1000 μM is less active than 1 (EC50 of 76 μM) may be due to the S-alkylated on the structure which eliminated its activity. Compound 1 showed higher activity than ascorbic acid (EC50 of 561.36 μM) so that it is potential as antioxidant agent.
The prebiotic production by using cassava peels with the addition of both K+ and Mg2+ metal ions as an activator and their potential to enhance broiler quality
Authors: Wahyuni S , Agustina A S , Natsir H , Raya I 
Published: November 2019

Abstract
Prebiotic is a nutrient for probiotic bacteria in the digestive tract of broilers. Prebiotics are used as a substitute for antibiotics in stimulating safer broiler growth. This study aims to determine the effect of prebiotics on broiler weight gain, the effect of prebiotics on the addition of metal ion combinations, and the effect of antibiotics when compared with controls. Prebiotic production is carried out using cassava peels as a substrate and Lactobacillus plantarum as an enzyme producer that acts as a catalyst. The cofactor used is a combination of metal ions K+ and Mg2+. Prebiotic administration was carried out for 23 days with a volume of 1 mL/L as well as the determination of blood cholesterol levels in broilers. The results showed that the weight of broiler s given prebiotics was 1230.75 grams with blood cholesterol levels 143 mg/dL. At the control of 1079.5 grams with a blood cholesterol level of 255.5 mg/dL. Antibiotics amounted to 1120.75 grams with blood cholesterol levels of 178 mg/dL. In prebiotics, metal ions of 0.4 mM are added; 0.6 mM; and 0.8 mM in a row of 1254.25 grams; 1192 grams; and 1167.25 grams with blood cholesterol levels 131 mg/dL; 132 mg/dL; and 145.5 mg/dL. This study showed that prebiotic administration affected broiler weight gain and blood cholesterol levels.
The application of algebraic methods to simplify the more complex type of static data structure through visualization approach
Authors: Hasbi M 
Published: November 2019

Abstract
This paper had the result of action research (AR) of Data Structure course. This paper discussed the elaboration of hight level complexity of composit type of data structure applying algebraic method through visualization approach (VA). The purpose of this research was to simplify the students understanding at any levels of complexity of static type of data structures through the application of algebraic methods with visualization approach. The roles of the applications were the elaboration of any level of type complexity of data structures logically and systematically at to identify each of their individual access. The method applied to this AR was an algebraic method through visualization approach of composite type of data structures in two cycles. The first cycle applied manually visualization approach, and the second applied simple MS-Powerpoint animation of visualization approach. Some examples of third complexity level of composite type of data structures were presented to demonstrate the methods. The results showed that, before the method is applied, none of the 43 students participating in the course of data structures that can be logically and systematically identifies each individual access from any type of data structure composites tested. How ever, after the second cycle levels of AR applying VM shown that the average score of learning outcome was 78.00 and classical mastery learning achievement was 76.74%. It meant that the students achievement were very hight. The conclusion was the application of VM significanly improved data structure programmer competency.
Decision Support System on Potential Land Palm Oil Cultivation using Promethee with Geographical Visualization
Authors: Widians J A , Taruk M , Fauziah Y , Setyadi H J 
Published: November 2019

Abstract
Preparation of oil palm cultivation land is the initial physical activity of the planting area. Prior to oil palm cultivation it is advisable to study potential land suitability, to assess the land as appropriate or not to oil palm growth and support crop productivity. Potential land evaluation includes an example of a consideration where it requires the right decision to make a potential land-cultivation way to support crop productivity more effectively. Therefore, system with the PROMETHEE (Preference Ranking Organization for Enrichment Evaluation) method is built because of the ability to handle multiple comparisons, indicating priorities and preferences for each criterion by focusing on values. The criteria needed are: Rainfall, Dry Moon, Topography, Above Sea Level, Soil Acidity, Slope Tilt and Peat Density. The results achieved in this research is decision support system that yields recommendation of potential land of oil palm cultivation, which can be considered by decision maker in determination of potential land of oil palm cultivation.
Placement of photovoltaic and capacitors in the 20 kV Jeneponto Distribution Network
Authors: Arief A , Nappu M B , Nur D H 
Published: November 2019

Abstract
Indonesia is located on the equator which has a good intensity of solar radiation throughout the year. This radiation condition gives the potential for photovoltaic placement in Indonesia. Jeneponto Regency is one of the areas in South Sulawesi that has the high potential for the construction of photovoltaic (PV) with irradiation levels reaching 5.404 kWh/m2/day. This research aims to determine the location of photovoltaic and capacitor interconnection points in the 20 kV Jeneponto distribution system for optimizing voltage stability and minimizing power losses. The optimal simulation of the determination of interconnection points is carried out by simulating photovoltaic placement in different main buses, which are Jeneponto main distribution substation, Jeneponto switching substation, Tolo switching substation and Benteng switching substation. The results analysis showed that the photovoltaic interconnection point in Benteng switching substation produces the smallest power losses and all loads have a voltage profile that complies with both IEEE and PLN voltage standards.
Some Properties Associated with Clifford-Fourier Transform
Authors: Bahri Mawardi , Azis Moh. Ivan , Aris Naimah , Lande Chrisandi 
Published: November 2019

Abstract
Several useful properties of the Clifford-Fourier transform have been studied recently and many are being investigated at present. In this paper, we explore more properties of the Clifford-Fourier transform. We find that the properties are extensions of corresponding properties of the classical Fourier transform.
On the derivation of a boundary element method for diffusion convection-reaction problems of compressible flow in exponentially inhomogeneous media
Authors: Nafie N L , Taba P , Latunra A I , Fahruddin  , Azis M I 
Published: November 2019

Abstract
Boundary value problems (BVPs) of anisotropic and exponentially-graded media governed by a diffusion convection-reaction (DCR) equation are considered. The governing equation is of spatially varying coefficients (with an anisotropic diffusion coefficient). The variable coefficients equation is firstly transformed into a constant coefficients equation, from which we derive a boundary integral equation. A boundary element method (BEM) is then constructed to be used for finding numerical solutions to the BVPs. For the computation of the solutions a FORTRAN code is developed. Some examples of problems are solved. The numerical solutions obtained verify the validity of the analysis used to construct the boundary element method with accurate and consistent solutions. The results also show that the BEM procedure elapses very efficient time in producing the solutions. In addition, the results indicate the effect of anisotropy of the media on the solutions.
Boundary element method solutions for steady anisotropic-diffusion convection problems of incompressible flow in quadratically graded media
Authors: Baja S , Arif S , Fahruddin  , Haedar N , Azis M I 
Published: November 2019

Abstract
A boundary element method is utilized to find numerical solutions to boundary value problems of quadratically graded media governed by a spatially varying coefficients anisotropic-diffusion convection equation. The variable coefficients equation is firstly transformed into a constant coefficients equation for which a boundary integral equation can be formulated. A boundary element method (BEM) is then derived from the boundary integral equation. Some problems are considered. The numerical solutions justify the validity of the analysis used to derive the boundary element method with accurate and consistent solutions. A FORTRAN script is developed for the computation of the solutions. The computation shows that the BEM procedure elapses very efficient time in producing the solutions. In addition, results obtained from the considered examples show the effect of the anisotropy and the inhomogeneity of the media on the solutions. An example of a layered material is presented as an illustration of the application.
On the derivation of a boundary element method for steady anisotropic-diffusion convection problems of incompressible flow in trigonometrically graded media
Authors: Sakka  , Syamsuddin E , Abdullah B , Azis M I , Siddik A M A 
Published: November 2019

Abstract
A boundary element method is utilized to find numerical solutions to boundary value problems of trigonometrically graded media governed by a spatially varying coefficients anisotropic-diffusion convection equation. The variable coefficients equation is firstly transformed into a constant coefficients equation for which a boundary integral equation can be formulated. A boundary element method (BEM) is then derived from the boundary integral equation. Some problems are considered. The numerical solutions justify the validity of the analysis used to derive the boundary element method with accurate and consistent solutions. A FORTRAN script is developed for the computation of the solutions. The computation shows that the BEM procedure elapses very efficient time in producing the solutions. In addition, results obtained from the considered examples show the effect of the anisotropy of the media on the solutions. An example of a layered material is presented as an illustration of the application.
Text Encryption Algorithm based on Chaotic Map
Authors: Irsan M Y T , Antoro S C 
Published: November 2019

Abstract
To maintain the confidential data, a scheme or algorithm is needed to protect the data from many attacks. Recently, many cryptography schemes and algorithms have been introduced. One of them is the cryptography algorithm based on chaotic maps. The nature of the chaotic maps gives many advantages to the algorithm. In this paper, an algorithm to encrypt the text is purposed. The algorithm utilizes the nature of the chaotic map by using the MS map as a keystream generator. The ciphertext found by the purposed algorithm is very difficult to be cracked by the bruce-force attack and known-plaintext attack. The decryption process has been tested using 3 different secret keys (that is very similar with the secret key on the encrypted process), and resulting the decrypted text is the same with plaintext only if the input is exactly the same secret key as in encrypted process.
Critical illness insurance pricing with stochastic interest rates model
Authors: Alim K , Listiani A , Anggraeni A S , Effendie A R 
Published: November 2019

Abstract
In this paper, we will explain critical illness insurance calculations with stochastic interest rates. The survival model is multiple states, while the interest rate is the Cox-Ingersoll-Ross stochastic interest rate model. In determining the survival model, we use the prevalence and mortality rates of certain critical diseases, such as neoplasms, endocrine diseases, and diseases of the digestive system. Furthermore, the Monte Carlo simulation will be used to simulate the possibility of interest rate pathways in determining critical illness insurance premiums.
Morbidity-Mortality Table Construction for Eleven Chronical Diseases (ECD) Using Constant Force Assumption
Authors: Anggraeni Andini Setyo , Listiani Amalia , Alim Khairul , Effendie Adhitya Ronnie 
Published: November 2019

Abstract
This paper describes the construction of morbidity-mortality table if the dataset is only available at ages interval. The table used to measure the interaction between morbidity and mortality on the eleven chronical diseases (ECD). The probabilistic framework is based on the multiple-states Markov model. The transition intensities are assumed constant in each age interval. This paper finds high probability someone stays in state ECD and higher probability someone dies because of ECD than other causes.
Multinomial method for pricing Lookback Option
Authors: Sudding F N F , Irsan M Y T 
Published: November 2019

Abstract
One way to avoid or minimize risk due to price fluctuation of asset price in the market is through option trading. Lookback option is a contract that gives a holder right but not the obligation to buy/sell a certain asset at minimum/maximum price during certain time. Lookback option has two types, namely fixed strike lookback and floating strike lookback. The metode used was multinomial method. The parameters used are initial asset price, strike price, risk-free interes rate, time to maturity, and volatility. The method has been applied, and obtained that the increasing of the order of the multinomial method do not give significant changes to the price of the option. Another conclusion we get is for fixed strike price, the put is more expensive then the call, different with floating strike, the call is more expensive than the put.
On Weak Solution of Cauchy Problem for Nonlinear Parabolic Equations
Authors: Aris Naimah , Nisardi Muh. Rifki , Kasbawati  , Kusuma Jeffry , Nurwahyu Budi , Mawardi  
Published: November 2019

Abstract
In this paper, we investigate weak solutions of Cauchy problem for nonlinear parabolic equations. By using Galerkin approximation, the existence and uniqueness of weak solutions are proved.
RESISTIVITY OF PROTEIN KINASE-B (AKT), NF-κB TRANSDUCTION OBSTACLES, AND APOPTOSIS INDUCTION (CASPACE -3, -9) AS ANTI-PROLIFERATION AND ANTI-CANCER OF BURKITT’S LYMPHOMA USING FLAVONOID FRACTION OF ETHYL ACETATE FROM ANT NEST (MYRMECODIA PENDANS)
Authors: Achmad Muhammad Harun , Ramadhany Sri , Ramadhany Yunita Feby 
Published: November 2019

Abstract

Introduction: Burkitt’s lymphoma (LB) is a tumor with high malignancy and rapid cell growth and originates from B-cell lymphoma. LB is usually found in children in endemic areas with dengue fever and HIV-AIDS with low socioeconomic levels. Objective: This research aims to analyze resistivity of protein kinase-B (Akt), NF-κB transduction obstacles, and apoptosis induction (Caspace -3, -9) as anti-proliferation and anti-cancer of burkiit’s lymphoma using flavonoid fraction of ethyl acetate from ant nest (Myrmecodia pendans). Material and Methods: The study was conducted in a pure laboratory experimental method using burkitt’s lymphoma cancer cell culture. Gradual research begins with the determination, extraction and fractionation of ant nest plants, to test for proliferation barriers. Data analysis using two-way ANOVA followed by Post Hoc LSD test with a significance level of 95%. Pearson correlation test was conducted. Results: Resistivity of protein expression of protein kinase-B (Akt), transcription factor of nuclear factor-kappa B (NF-κB), and apoptosis induction (Caspace -3,-9) showed increased protein expression was significantly obstacles and prove that the ethyl acetate fraction flavonoid inhibits translocation and activation of transcription pathway NF-κB and growth factors that induces the phosphorylation of Akt signal transduction pathway, and apoptosis induction (Caspace -3,-9). Conclusion: Flavonoid fraction of ethyl acetate from ant nest (Myrmecodia pendans) resistivity of protein kinase-B (Akt), NF-κB transduction obstacles, and apoptosis induction (Caspace -3, -9) as anti-proliferation and anti-cancer of burkitt’s lymphoma.
Physicochemical and Micromeritics Properties of Ketoprofen-Tartaric Acid Binary System
Authors: Himawan A , Djide N J N , Mudjahid M , Lukita A D I , Arjuna A , Aliyah  
Published: November 2019

Abstract
Physical characteristics of pharmaceutical active ingredients can be modified by molecular structure rearrangement inside its crystal lattice. Cocrystallization involved the formation of new crystal structure from two different crystal components. In its application in the pharmaceutical field, the formation of cocrystals can comprise the interaction between an active ingredient and an inert substance or between two different drugs. This study aimed to synthesize cocrystal from Ketoprofen and Tartaric Acid. Ketoprofen and Tartaric acid were ground with mortar for 10 minutes prior dissolving in methanol at 40°C with continuous stirring. The solution then filtered and evaporated at ambient temperature. The resulting crystal was ground before further characterization. The individual component and cocrystal were characterized using FTIR, Differential Scanning Calorimeter (DSC) and Powder X-Ray Diffractometer (PXRD). The results show that the acquired crystal mass, KET-TAR, is a mixture of a semi-crystalline phase and its non-interacting precursors New phase formation has been confirmed from both PXRD and DSC data. KET-TAR shows greater micromeritics properties compared to Ketoprofen with the value of angle of repose of, bulkiness, Carr’s Index, Haussner’s Ratio and Porosity are 25.3°, 1.8, 16.667, 1.200 and 61.7% consecutively. Overall improvement in micromeritic properties are clearly shown in the results.