bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coronary Angiography After Transcatheter Aortic Valve Replacement (TAVR) to Evaluate the Risk of Coronary Access Impairment After TAVR‐in‐TAVR
Authors: Nai Fovino Luca , Scotti Andrea , Massussi Mauro , Cardaioli Francesco , Rodinò Giulio , Matsuda Yuji , Pavei Andrea , Masiero Giulia , Napodano Massimo , Fraccaro Chiara , Fabris Tommaso , Tarantini Giuseppe 
Published: June 2020

Background

Transcatheter aortic valve replacement (TAVR)‐in‐TAVR is a possible treatment for transcatheter heart valve (
THV
) degeneration. However, the displaced leaflets of the first
THV
will create a risk plane (
RP
) under which the passage of a coronary catheter will be impossible. The aim of our study was to evaluate the potential risk of impaired coronary access (
CA
) after
TAVR
‐in‐
TAVR
.

Methods and Results

We prospectively performed coronary angiography after
TAVR
with different
THV
s in 137 consecutive patients, looking where the catheter crossed the valve frame. If coronary cannulation was achieved from below the
RP
, the distance between valve frame and aortic wall was measured by aortic angiography.
CA
after
TAVR
‐in‐
TAVR
was defined as feasible if the catheter passed above the
RP
, as theoretically feasible if passed under the
RP
with valve‐to‐aorta distance >2 mm, and as unfeasible if passed under the
RP
with valve‐to‐aorta distance ≤2 mm. Seventy‐two patients (53%) received a Sapien 3 THV, 26 (19%) received an Evolut Pro/R THV, and 39 (28%) received an Acurate Neo
THV
.
CA
after
TAVR
‐in‐
TAVR
was considered feasible in 40.9% (68.1%, 19.2%, and 5.1%, respectively;
P
<0.001), theoretically feasible in 27.7% (8.3%, 42.3%, and 53.8%, respectively;
P
<0.001), and unfeasible in 31.4% (23.6%, 38.5%, and 41.1%, respectively;
P
=0.116). Independent predictors of impaired
CA
after
TAVR
‐in‐
TAVR
were female sex (odds ratio [OR], 3.99; 95%
CI
, 1.07–14.86;
P
=0.040), sinotubular junction diameter (OR, 0.62; 95%
CI
, 0.48–0.80;
P
<0.001), and implantation of a supra‐annular
THV
(OR, 6.61; 95%
CI
, 1.98–22.03;
P
=0.002).

Conclusions

CA
after
TAVR
‐in‐
TAVR
might be unfeasible in >30% of patients currently treated with
TAVR
. Patients with a small sinotubular junction and those who received a supra‐annular
THV
are at highest risk of potential
CA
impairment with
TAVR
‐in‐
TAVR
.
Schengen: Quo Vadis?
Authors: De Somer Marie 
Published: June 2020

Abstract
The EU’s Schengen zone has been in crisis for over four years. This article critically reviews three scenarios on the way forward for the Schengen area that are currently circulating in the EU policy sphere. These include, first, proposals to improve the current rules on internal border checks within the Schengen Borders Code, either through reform or through better implementation practices. A second scenario relates to ideas on increasing the use of police checks in border regions as alternatives for internal border controls. A third scenario links to proposals on making access to the Schengen zone conditional on cooperation and good governance in the CEAS. It is submitted that the proposals in this third scenario are unfeasible for both political as well as legal reasons. More merit can be found in the discussions around the first two scenarios, albeit bearing in mind a number of important caveats.
The Recast Reception Conditions Directive and the Rights of Asylum Seekers with Disabilities: Opportunities, Challenges and the Quest for Reform
Authors: O’Sullivan Charles , Ferri Delia 
Published: June 2020

Abstract
In recent years, the European Union (EU) has, like much of the developed world, experienced a sustained period of inward migration from refugee-producing States in Africa and the Middle-East. This ‘refugee crisis’ has placed a strain not only on the political will of the EU institutions and Member States to find a satisfactory resolution to deal with the flow of migrants, but also on their ability to put in place fair processes for any resulting claims for asylum and to adequately support the needs of asylum seekers while those claims are being processed. This article discusses the latter issue from a discreet angle, focusing on how the EU has addressed the needs of asylum seekers with disabilities. As a party to the United Nations Convention on the Rights of Persons with Disabilities (CRPD), which enjoys sub-constitutional status within the EU legal order, the EU is obligated to interpret all legislation in light of the Convention. Thus, this article seeks to assess the degree to which Directive 2013/33/EU on the material reception conditions for asylum seekers can protect and promote the rights of asylum seekers with disabilities and fulfill the ‘human rights model of disability’ embedded within the CRPD. It also assesses the most recent proposal to replace the Directive, and examines whether the potential shortcomings within it have been addressed thus far. Ultimately, it finds that the ambiguities and lack of procedural certainty within the current Directive provide too much room to derogate from the standards arguably mandated by the Convention, and these have yet to be addressed within the new Proposal.
Consistency of Satellite Climate Data Records for Earth System Monitoring
Authors: Popp Thomas , Hegglin Michaela I. , Hollmann Rainer , Ardhuin Fabrice , Bartsch Annett , Bastos Ana , Bennett Victoria , Boutin Jacqueline , Brockmann Carsten , Buchwitz Michael , Chuvieco Emilio , Ciais Philippe , Dorigo Wouter , Ghent Darren , Jones Richard , Lavergne Thomas , Merchant Christopher J. , Meyssignac Benoit , Paul Frank , Quegan Shaun , Sathyendranath Shubha , Scanlon Tracy , Schröder Marc , Simis Stefan G. H. , Willén Ulrika 
Published: June 2020

Abstract
Climate data records (CDRs) of essential climate variables (ECVs) as defined by the Global Climate Observing System (GCOS) derived from satellite instruments help to characterize the main components of the Earth system, to identify the state and evolution of its processes, and to constrain the budgets of key cycles of water, carbon, and energy. The Climate Change Initiative (CCI) of the European Space Agency (ESA) coordinates the derivation of CDRs for 21 GCOS ECVs. The combined use of multiple ECVs for Earth system science applications requires consistency between and across their respective CDRs. As a comprehensive definition for multi-ECV consistency is missing so far, this study proposes defining consistency on three levels: 1) consistency in format and metadata to facilitate their synergetic use (technical level); 2) consistency in assumptions and auxiliary datasets to minimize incompatibilities among datasets (retrieval level); and 3) consistency between combined or multiple CDRs within their estimated uncertainties or physical constraints (scientific level). Analyzing consistency between CDRs of multiple quantities is a challenging task and requires coordination between different observational communities, which is facilitated by the CCI program. The interdependencies of the satellite-based CDRs derived within the CCI program are analyzed to identify where consistency considerations are most important. The study also summarizes measures taken in CCI to ensure consistency on the technical level, and develops a concept for assessing consistency on the retrieval and scientific levels in the light of underlying physical knowledge. Finally, this study presents the current status of consistency between the CCI CDRs and future efforts needed to further improve it.
Fragility Vertebral Compression Fractures in Postmenopausal Women: The Role of a Fracture Liaison Service Program
Authors: Jackson Avery , Wasfie Tarik , Brock Caramarie , Galovska Stefanija , Smalley Melany , Grundman Kendra , Hella Jennifer R. 
Published: June 2020

Background As the aging population increases in the United States, so has the prevalence of osteoporosis (10.2 million adults aged 50 years and older in 2010). Programs to manage the increased incidence of fragility fractures in such patients particularly the postmenopausal women are the priority. Programs such as the Fracture Liaison Service (FLS) might be the answer. Methods Data of 256 postmenopausal women with vertebral compression fractures treated with vertebroplasty between 2012 and 2017 were divided into 2 groups. Group A were patients seen between 2012 and 2014 before the establishment of the FLS program at the clinic. Group B were patients seen between 2015 and 2017 who presented to the FLS program in our clinic. Data collected included demographics, refracture rates, dual-energy X-ray absorptiometry (DEXA) scan T-scores, fracture risk score (FRAX), serum calcium and vitamin D levels, and comorbid conditions. Results There were 103 female patients with a mean age of 79.75 years (standard deviation [SD] ± 10.86) in group A, while group B had 153 patients with a mean age of 75.66 years (SD ± 10.78). There was no significant difference in the DEXA scan T-scores, FRAX scores, and mean serum calcium and vitamin D levels; however, there was a significant reduction in the refracture rate for vertebral compression fractures ( P = .003). Conclusion FLS programs, when implemented, will have a beneficial effect in reducing refracture rates of postmenopausal women with osteoporotic fragility fractures.
Incidence of Inner Ear Disorders in Various Forms of Acute Otitis Media in ENT Practices in Germany
Authors: Seidel David Ulrich , Bode Simon , Kostev Karel , Park Jonas Jae-Hyun 
Published: June 2020

Objective: The aim of this study was to determine the incidence of inner ear involvement in various forms of acute otitis media (AOM) in ear, nose, and throat (ENT) practices in Germany. Methods: Patients who had been diagnosed with various forms of AOM in the years 2010 to 2017 were enrolled in the study from a nationwide, representative practice database (Disease Analyzer, IQVIA). In these patients, the incidence of simultaneous or subsequent inner ear disorders (IED) was determined within 7 days and within 12 months from the date of an AOM diagnosis. Results: A total of 286 186 patients with AOM were enrolled. The most frequent diagnoses were “nonsuppurative otitis media, unspecified” (47.6%) and “otitis media, unspecified” (39.0%). The diagnoses of hemorrhagic bullous myringitis (BM) or influenza-induced AOM were very rarely found in the database. The highest incidence of IED after 7 days and 12 months was found in “nonsuppurative otitis media, unspecified” (7.7% and 15.9%, respectively), followed by “otitis media, unspecified” (5.6% and 13.5%, respectively). The incidences of the most frequent IED “hearing loss, unspecified” and “sensorineural hearing loss, unspecified” increased proportionally with increasing patient age, while the rare diagnoses of “labyrinthitis” and “ototoxic hearing loss” were evenly distributed among the age groups. Conclusion: In ENT practices in Germany, both various forms of AOM, as well as simultaneous or subsequent IED, are mostly being coded in an unspecific way, while specific forms such as hemorrhagic BM, influenza-induced AOM, and labyrinthitis are coded very rarely. Older patients have a higher risk of IED in AOM. A visit due to AOM seems to be a regular occasion for the initial diagnosis of hearing impairment in the elderly individuals. The highest risk of IED was found in nonsuppurative AOM.
Intracranial hemorrhage on extracorporeal membrane oxygenation: an international survey
Authors: Cavayas Yiorgos Alexandros , Del Sorbo Lorenzo , Munshi Laveena , Sampson Caroline , Fan Eddy 
Published: June 2020

Introduction: Intracranial hemorrhage is one of the most dreaded complications associated with extracorporeal membrane oxygenation. However, robust data to guide clinical practice are lacking. We aimed to describe the current perceptions and practices surrounding the risk, prevention, diagnosis, management, and prognosis of intracranial hemorrhage in patients on extracorporeal membrane oxygenation. Methods: We conducted an international, cross-sectional survey of adult extracorporeal membrane oxygenation centers using a self-administered electronic questionnaire sent to medical directors and program coordinators of all 290 adult centers member of the Extracorporeal Life Support Organization. Results: There were 143 respondents (49%). The median proportion of patients having neuroimaging performed was only 1-25% in venovenous-extracorporeal membrane oxygenation patients and 26-50% in venoarterial-extracorporeal membrane oxygenation and extracorporeal cardiopulmonary resuscitation. The majority of participants (58%) tolerated a PaO2 < 60 mm Hg on venovenous-extracorporeal membrane oxygenation. Lower PaO2 targets were inversely correlated with the reported incidence of intracranial hemorrhage (r =−0.247; p = 0.024). In patients with intracranial hemorrhage, most participants reported stopping anticoagulation, and median targets for blood product administration were 70,000-99,000 platelets/µL, 1.5-1.9 of international normalized ratio, and 1.6-2.0 g/L of fibrinogen. Conclusion: We found significant heterogeneity in the perceptions and practices. This underlines the need for more research to appropriately guide patient management. Importantly, neuroimaging was performed only in a minority of patients. Considering the important management implications reported by most centers when intracranial hemorrhage is diagnosed, perhaps clinicians should consider widening their indications for early neuroimaging.
Effects of trigger point dry needling on lateral epicondylalgia of musculoskeletal origin: a systematic review and meta-analysis
Authors: Navarro-Santana Marcos J , Sanchez-Infante Jorge , Gómez-Chiguano Guido F , Cleland Joshua A , López-de-Uralde-Villanueva Ibai , Fernández-de-las-Peñas César , Plaza-Manzano Gustavo 
Published: June 2020

Objective: This meta-analysis evaluated the effect of dry needling alone or combined with other treatment interventions on pain, related-disability, pressure pain sensitivity, and strength in people with lateral epicondylalgia of musculoskeletal origin. Data Sources: MEDLINE, CINAHL, PubMed, PEDro, Cochrane Library, SCOPUS and Web of Science databases from their inception to 5 April 2020. Review Methods: Randomized controlled trials collecting outcomes on pain, related-disability, pressure pain thresholds, or strength where one group received dry needling for lateral epicondylalgia of musculoskeletal origin. The risk of bias was assessed by the Cochrane Guidelines, methodological quality was assessed with the PEDro score, and the quality of evidence by using the GRADE approach. Results: Seven studies including 320 patients with lateral epicondylalgia were included. The meta-analysis found that dry needling reduced pain intensity (SMD ‒1.13, 95%CI ‒1.64 to ‒0.62) and related-disability (SMD ‒2.17, 95%CI ‒3.34 to ‒1.01) with large effect sizes compared to a comparative group. Dry needling also increased pressure pain thresholds with a large effect size (SMD 0.98, 95%CI 0.30 to 1.67) and grip strength with a small size effect (SMD 0.48, 95%CI 0.16 to 0.81) when compared to a comparative group. The most significant effect was at short-term. The risk of bias was generally low, but the heterogenicity of the results downgraded the evidence level. Conclusion: Low to moderate evidence suggests a positive effect of dry needling for pain, pain-related disability, pressure pain sensitivity and strength at short-term in patients with lateral epicondylalgia of musculoskeletal origin. Level of Evidence: Therapy, level 1a. Registration number: OSF Registry - https://doi.org/10.17605/OSF.IO/ZY3E8
Associations of platelet indices with proteinuria and chronic kidney disease
Authors: Kemeç Zeki , Demir Mustafa , Gürel Ali , Demir Fadime , Akın Selçuk , Doğukan Ayhan , Gözel Nevzat , Ulu Ramazan , Koca S. Serdar 
Published: June 2020

Objectives Platelet (PLT) indices are predictive in many diseases and conditions. The relationships of these indices with proteinuria and progression of renal disease are not well known. This study aimed to assess PLT indices in patients with primary glomerular nephrotic range proteinuria (PGNRP), with and without chronic kidney disease (CKD), and to compare these indices with those of healthy individuals (His). Methods This cross-sectional study was performed from January 2015 to May 2015. HIs (n = 57) and patients with PGNRP (n = 41) were enrolled. PLT indices and blood biochemistry parameters were compared between HIs and patients with PGNRP, as well as between subgroups of patients with PGNRP who had CKD (n = 23) and those who did not have CKD (n = 18). Results There were no statistically significant differences in any PLT indices (i.e., platelet number, mean platelet volume, plateletcrit, and platelet distribution width) between HIs and patients with PGNRP, or between the subgroups of patients with PGNRP. However, patients with PGNRP who had CKD exhibited higher median C-reactive protein and mean albumin levels, compared with patients who did not have CKD. Conclusions Pathological processes in proteinuria and CKD are not associated with PLT indices.
Stability of the Antimicrobial Capacity of Human Milk Against Cronobacter Sakazakii During Handling
Authors: Fernández-Pastor Sandra , Castelló Dolores Silvestre , López-Mendoza M.C. 
Published: June 2020

Background Neonatal infections with Cronobacter sakazakii have recently been associated with the consumption of expressed human milk. Study Aims (1) To evaluate whether human milk has antimicrobial capacity against C. sakazakii and (2) to determine the stability of its capacity when it is subjected to various treatments. Methods The antimicrobial capacity of human milk against C. sakazakii was evaluated using an observational, cross-sectional, comparative design. Mature human milk samples ( N = 29) were subjected to different treatments. After incubation at 37°C for 72 hr, samples were compared with fresh milk on the stability of their antimicrobial capacity. Two-way analysis of variance (ANOVA) was performed. Results In fresh milk, counts of C. sakazakii were reduced by 47.26% ( SD = 6.74) compared to controls. In treated milk, reductions were: refrigeration at 4°C for 72 hr ( M = 33.84, SD = 13.84), freezing at –20°C for 1, 2, and 3 months ( M = 40.31, SD = 9.10; M = 35.96, SD = 9.39; M = 26.20, SD = 13.55, respectively), Holder pasteurization ( M = 23.56, SD = 15.61), and human milk bank treatment with ( M = 14.37, SD = 18.02) and without bovine fortifier ( M = 3.70, SD = 23.83). There were significant differences ( p < .05) between fresh and treated milk. Conclusions Human milk has antimicrobial capacity against C. sakazakii. However, its capacity is negatively influenced by common preservation and hygienization methods. Milk should be stored refrigerated for a maximum of 72 hr or frozen for a short period of time.
Use of Embolectomy With Local Anesthesia for Anticoagulation Failure in Radial Artery Thrombosis
Authors: Yılmaz Metin , Sönmez Serkan , Uğur Oğuz , Gül Murat , Yıldırım Oğuz , Özkan Deniz , Aytekin Bahadır , İnce İlker 
Published: June 2020

Objective: Although prevention of radial artery thrombosis and cardiac complications after interventions using radial access is well investigated, there is yet no clinical study that completely evaluated access-related complications. However, there is still no consensus on what exact treatment should be used in these patients. In clinical practice, analgesic, anticoagulant, and antiplatelet treatments usually improve symptoms in patients with pain; however, in some patients, complaints may persist and may not respond to these treatments. In these patients, low-risk embolectomy with a small skin incision may be beneficial. Methods: A total of 102 patients with radial artery thrombosis after cardiac catheterization were included in the study between 2016 March and 2018 December. After the patients’ initial evaluation, anticoagulation with enoxaparin or tinzaparin and antiplatelet therapy with acetylsalicylic acid and oral/local analgesic/anti-inflammatory and local anesthetic therapy were administered for 1 month. Patients whose symptoms resolved after medical treatment were followed up as outpatients. Embolectomy was performed in consenting patients who did not respond to the medical treatment. Results: Of 102 patients included in the study, 33 underwent embolectomy, whereas 69 received only medical treatment. None of the patients experienced any complications, morbidity, or mortality in the peroperative period and during the medical treatment. The pretreatment symptom scores of patients who actively use their hands in daily life and profession were significantly higher than the scores of patients who are relatively less active ( P = .013). Pretreatment symptom scores were negatively correlated with age ( r = −0.584); symptom scores increased significantly with the decrease of patient age. No benefit from medical treatment and need for surgery was significantly greater in patients who are younger and use their hands actively in daily life and profession ( P = .028). The decrease in symptom scores after treatment was significantly greater in the surgical group than in the medical group ( P = .003). Conclusion: Radial access should be exercised with care in patients who may develop significant thrombosis-related complaints and it is necessary to decide whether radial access is essential. If patients have ongoing symptoms despite medical treatment, embolectomy can be considered as a treatment option.
Retinal vein occlusion and chronic kidney disease: A meta-analysis
Authors: Fang Li Jian , Dong Li , Li Yi Fan , Wei Wen Bin 
Published: June 2020

Objectives: We performed this meta-analysis to assess the correlation of retinal vein occlusion (RVO) and chronic kidney disease (CKD). Methods: We searched PubMed, Embase, Web of Science and Cochrane Library for population-based studies reporting the CKD as associated factor to RVO, central retinal vein occlusion (CRVO) or branch retinal vein occlusion (BRVO). Then we pooled the data for analysis. Results: After screening potential literature, 12 eligible studies with 23,656,214 individuals were finally included in quantitative synthesis. The pooled prevalence (95% confidence interval [CI]) of CKD in RVO group was 10.9% (95% CI: 6.6%, 15.1%). The pooled prevalence of any RVO in end stage renal disease (ESRD) group was 1.8% (95% CI: 1.6%, 2.1%). The prevalence of CKD was significantly higher in subjects diagnosed with RVO than non-RVO participants (odds ratio [OR]: 3.30; 95% CI: 2.28, 4.76; p < 0.001). CRVO subjects had a higher prevalence of CKD than BRVO patients (OR: 2.17; 95% CI: 1.28, 4.66; p = 0.004). In a similar manner, compared to non-ESRD subjects, ESRD patients had significantly higher prevalence of RVO (OR: 2.19; 95% CI: 1.97, 2.43; p < 0.001), CRVO (OR: 2.61; 95% CI: 2.17, 3.15; p < 0.001) and BRVO (OR: 2.01; 95% CI: 1.76, 2.30; p < 0.001). Conclusion: The prevalence of CKD increases in RVO patients, especially in CRVO. And in turn, the prevalence of RVO also increases in ESRD patients. The data support a correlation of RVO and CKD.