bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fault Adaptive Mission Planning: Increasing Useful-Life and Reducing Downtime Through Condition-Based Decision-Making
Authors: DeStefano Charlie , Jensen David 
Published: June 2020

AbstractThis paper presents a novel Fault Adaptive Mission Planning (FAMP) framework for complex systems aimed at increasing useful-life and reducing downtime through condition-based decision-making. A hallmark of complex systems is that they typically have access to multiple mission plans that allow their mission objectives to be accomplished in a variety of ways. In hopes of exploiting this characteristic, FAMP is the process of increasing a system's useful-lifespan by first determining how each potential mission plan affects the system's degradation differently, and then by implementing a planning strategy that utilizes this information to repeatedly recalculate a new mission plan as the system degrades. Fault-augmented physics models identify how component degradation will affect the system's current and future performance for a given mission plan. Then, at various degradation-based thresholds, new mission plans are installed such that whenever possible, the healthiest components are used more, or in different ways, than the more degraded components. This process promotes balanced degradation, preventing useful-life from being wasted and reducing downtime through synchronized maintenance schedules. This work expands the prognostics and health management paradigm by enabling life extension and maintenance reduction through real-time FAMP.
Two Methods to Assess Aortic Compliance Using Blood Pressure and Pulse-Wave Velocity
Authors: Manring Noah , Al-Toki Mouayed 
Published: June 2020

Abstract
Aortic compliance has been well established as an independent predictor of cardiovascular morbidity and mortality. The current "gold standard" for assessing aortic compliance is to use the carotid-femoral pulse-wave velocity (PWV) as a surrogate; however, PWV alone has been discussed in the literature as being inadequate for assessing compliance, especially for elderly patients and others who have a stiff aorta. In this paper an equation for the aortic compliance is developed using two approaches: 1) lumped-parameter modeling based on blood-pressure data and 2) distributed modeling based on the PWV. In-vitro experiments are conducted using a silicone-rubber tube which simulates the aorta, and an actual aorta harvested from a 1-year old, Holstein heifer. For both the rubber aorta and the Holstein aorta, a comparison is made between the blood-pressure model and the PWV model. In conclusion it is shown that good agreement exists between the two models, suggesting that either model may be used depending upon the available data. Furthermore, due to differences in material properties, it is shown that the compliance of the rubber aorta increases with mean arterial-pressure, while the compliance of the Holstein aorta decreases with mean arterial-pressure. Clinical implications of this research are also discussed.
Principal Component Analysis and Independent Component Analysis-Based Prognostic Health Monitoring of Electronic Assemblies Subjected to Simultaneous Temperature-Vibration Loads
Authors: Lall Pradeep , Thomas Tony 
Published: June 2020

Abstract
This paper discusses methods for estimating different feature vectors from strain signals of an electronic assembly under combined temperature and vibration load. A vibrational load of 14 G acceleration-level with an ambient temperature of 55 °C is selected as the operating conditions for this experiment. Strain signals were measured at different time intervals during the vibration of the printed circuit board, and resistance values of the packages on the printed circuit board are monitored to identify the failure. The frequency response was measured by taking the fast Fourier transform of the signal and quantized by frequency quantization techniques. These techniques were able to identify the increase in the number of higher frequency components in the strain signal before failure with increase vibration time. The time-frequency response was also compared by employing different time–frequency analysis, joint time–frequency analysis, and statistical techniques such as principal component analysis (PCA), and independent component analysis (ICA). Statistical techniques like PCA and ICA were used to identify the different patterns of the original strain and filtered signals. These techniques discretely separated the before and after failure strain signals but were unable to predict the progression of failure in the packages. The instantaneous frequency of the strain signal displayed an interesting behavior, in which the variance of the PCA components of the instantaneous frequency had an increasing trend and reached a maximum value before continuously decreasing and reaching a lower value just before failure, indicating a progression of the before failure strain components.
Acceleration Factor Modeling of Flexible Electronic Substrates From Actual Human Body Measurements
Authors: Lall Pradeep , Thomas Tony , Yadav Vikas , Narangaparambil Jinesh , Liu Wei 
Published: June 2020

Abstract
The use of flexible electronics wearable applications has prompted the need to understand the stresses imposed during human motion for a range of activities. Wearable applications may involve situations in which the electronics may be flexed-to-install, stretched or subjected to thousands cycles of dynamic flexing. In order to develop meaningful test-levels, a better understanding is needed of the use-cases, variance, and the acceleration factors. In this study, the human body motion data for walking, jumping, squats, lunges, and bicep curls were measured using a set of ten Vicon cameras to measure the position, velocity, and accelerations of a standard full-body sensor location of the human body. In addition, reliability data has been gathered on test vehicles subjected to dynamic flexing. Continuous resistance data have been gathered on circuits subjected to dynamic flexing till failure for some of the commonly used trace geometries in electronic circuits. Experimental measurements during the accelerated tests of the boards were combined with the human body motion data to model the acceleration factor for different human activities based on the flexing angles. Human motion for multiple subjects and multiple joints has been correlated to the test levels for the development of acceleration factors. Statistical analysis on the variation of the joint angles with hypothesis testing has been conducted for different subjects and for different human body actions. Acceleration factors models have been developed for walking, jumping, squats, lunges, and bicep curls.
Fate of pulmonary hypertension associated with bronchopulmonary dysplasia beyond 36 weeks postmenstrual age
Authors: Arjaans Sanne , Haarman Meindina G , Roofthooft Marcus T R , Fries Marian W F , Kooi Elisabeth M W , Bos Arend F , Berger Rolf M F 
Published: June 2020

ObjectiveTo determine the survival and evolution of pulmonary hypertension (PH) associated with bronchopulmonary dysplasia (BPD) in extremely premature born infants beyond 36 weeks postmenstrual age (PMA).DesignA single-centre retrospective cohort study from a university hospital.PatientsExtremely preterm (gestational age <30 weeks and/or birth weight <1000 g) infants, born between 2012 and 2017, in the University Medical Center Groningen with confirmed PH at/beyond 36 weeks PMA.Main outcome measuresSurvival, mortality rate and PH resolution. Patient characteristics, treatment, presence and evolution of PH were collected from patient charts.ResultsTwenty-eight infants were included. All had BPD, while 23 (82%) had severe BPD and 11 infants (39%) died. Survival rates at 1, 3 and 7 months from 36 weeks PMA were 89%, 70% and 58%, respectively. In 16 of the 17 surviving infants, PH resolved over time, with a resolution rate at 1 and 2 years corrected age of 47% and 79%, respectively. At 2.5 years corrected age, the resolution rate was 94%.ConclusionsThese extremely preterm born infants with PH-BPD had a survival rate of 58% at 6 months corrected age. Suprasystemic pulmonary artery pressure was associated with poor outcome. In the current study, infants surviving beyond the corrected age of 6 months showed excellent survival and resolution of PH in almost all cases. Prospective follow-up studies should investigate whether resolution of PH in these infants can be improved by multi-modal therapies, including respiratory, nutritional and cardiovascular treatments.
Novel approach to recording theatre utilisation data using Pinpoint: a wearable real-time location services device
Authors: O'Connell Robert Michael , Balasubramanian Ishwarya , Barron Fionn , Kelly Chris , O'Brien Eoin , Tormey Shona 
Published: June 2020

IntroductionInefficient theatre utilisation is costly for patients, staff and healthcare organisations. Active management projects have proven effective at identifying and streamlining delays in the perioperative patient journey.AimThe aim of this study is to assess whether a novel, wearable, autonomous, Wi-Fi-based real-time location services (RTLS) device could be used to accurately record and process theatre utilisation data.MethodsA novel RTLS device was employed in our theatre department between June and September 2017. Data were collected pertaining to time of arrival and departure from the surgical day ward, operating theatre and recovery using this device, and compared with our institution’s existing written record of theatre data.Results101 patients were enrolled, but manually recorded data were unavailable on 18 patients. Among the remaining 83 patients, mean difference in recorded start times was 0.43 min (p=0.64). Mean difference in theatre end times was 1.63 min (p=0.41). Mean difference recorded in overall time in theatre was 1.19 min (p=0.59).ConclusionThe RTLS device provided a reliable record of theatre utilisation, without requiring manual input, with potential as a tool to identify and improve inefficiencies in the theatre department.
Programmes to support transitions in care for children and youth with complex care needs and their families: a scoping review protocol
Authors: Doucet Shelley , Curran Janet A , Breneol Sydney , Luke Alison , Dionne Emilie , Azar Rima , Reid Amy E , McKibbon Shelley , Horsman Amanda R , Binns Krystal 
Published: June 2020

IntroductionChildren and youth with complex care needs (CCNs) and their families experience many care transitions over their lifespan and are consequently vulnerable to the discontinuity or gaps in care that can occur during these transitions. Transitional care programmes, broadly defined as one or more intervention(s) or service(s) that aim to improve continuity of care, are increasingly being developed to address transitions in care for children and youth with CCNs. However, this literature has not yet been systematically examined at a comprehensive level. The purpose of this scoping review is to map the range of programmes that support transitions in care for children and youth with CCNs and their families during two phases of their lifespan: (1) up to the age of 19 years (not including their transition to adult healthcare) and (2) when transitioning from paediatric to adult healthcare.Methods and analysisThe Joanna Briggs Institute methodology for scoping reviews (ScR) will be used for the proposed scoping review. ScR are a type of knowledge synthesis that are useful for addressing exploratory research questions that aim to map key concepts and types of evidence on a topic and can be used to organise what is known about the phenomena. A preliminary search of PubMed was conducted in December 2018.Ethics and disseminationEthical approval is not required where this study is a review of the published and publicly reported literature. The research team’s advisory council will develop a research dissemination strategy with goals, target audiences, expertise/leadership, resources and deadlines to maximise project outputs. The end-of-grant activities will be used to raise awareness, promote action and inform future research, policy and practice on this topic.
Study design and baseline characteristics of Shenzhen ageing-related disorder cohort in China
Authors: Liu Li , Liu Wei , Nie Lulin , Guo Zhiwei , Luo Yi , Chen Weihong , Liu Weimin , Zhu Feiqi , Wang Lu , Zhang Jiafei , Wang Xian , Li Tian , Gao Erwei , Zhou Li , He Kaiwu , Huang Yidan , Yuan Chunjie , Zhu Qingqing , Ye Fang , Yu Xingchen , Yuan Jing , Liu Jianjun 
Published: June 2020

PurposeThe Shenzhen ageing-related disorder cohort was designed to detect the associations of lifestyle, environmental and genetic factors with major ageing-related disorders, especially neurological and mental disorders.ParticipantsThe cohort was a community-dwelling prospective study of 9411 elderly adults aged 60 to 92 years from 51 community health service centres in Luohu district of Shenzhen, China. The baseline data were collected between 2017 and 2018, including demographics and socioeconomics, lifestyles, medical history, family history of major non-communicable chronic disease, environmental exposures, clinical analysis of blood and urine, clinical imaging measurements, anthropometric measures and neurological function and mental health assessments. Blood and urinary samples were collected at baseline. All participants will be followed for physiological and psychological disorders and updated lifestyle and environmental exposures every 5 years.Findings to dateThe mean age of the participants was 67.73 years at baseline, and 42.74% were males. The prevalences of individuals with unhealthy conditions were as follows: overweight/obesity (54.38%), hypertension (58.24%), diabetes mellitus (22.30%), dyslipidaemia (75.69%), chronic bronchitis (1.45%), myocardial infarction (0.55%), coronary heart disease (5.69%), stroke (1.10%), cancer (2.18%), arthritis (5.04%), Alzheimer’s disease (0.18%), Parkinson’s disease (0.23%), brain injury (5.75%), cognitive impairment (5.39%) and depression status (3.28%). The mean scores for the Lawton-Brody Activities of Daily Living Scale and the Social Support Rate Scale were 14.15 and 39.54, respectively.Future plans2000 new entrants from Luohu district will be recruited every year until 2028. The data collection is expected to be ended at the end of 2030. The data will be used to assess the causality of ageing-related disorders, especially neurological and mental disorders through integrating environmental, genetic and lifestyle factors. The data sets generated and/or analysed during the current study are not publicly available at this stage, but are available from the corresponding author on reasonable request.
Standardised patient encounters to improve quality of counselling for pre-exposure prophylaxis (PrEP) in adolescent girls and young women (AGYW) in Kenya: study protocol of a cluster randomised controlled trial
Authors: Larsen Anna , Wilson Kate S , Kinuthia John , John-Stewart G , Richardson BA , Pintye Jillian , Abuna Felix , Lagat Harison , Owens Tamara , Kohler Pamela 
Published: June 2020

IntroductionAdolescent girls and young women (AGYW) in sub-Saharan Africa are at high risk of HIV acquisition. Pre-exposure prophylaxis (PrEP) demonstration projects observe that AGYW uptake and adherence to PrEP during risk periods is suboptimal. Judgemental interactions with healthcare workers (HCW) and inadequate counselling can be barriers to PrEP use among AGYW. Improving HCW competency and communication to support PrEP delivery to AGYW requires new strategies.Methods and analysisPrEP Implementation for Young Women and Adolescents Program-standardised patient (PrIYA-SP) is a cluster randomised trial of a standardised patient actor (SP) training intervention designed to improve HCW adherence to PrEP guidelines and communication skills. We purposively selected 24 clinics offering PrEP services under fully programmatic conditions in Kisumu County, Kenya. At baseline, unannounced SP ‘mystery shoppers’ present to clinics portraying AGYW in common PrEP scenarios for a cross-sectional assessment of PrEP delivery. Twelve facilities will be randomised to receive a 2-day training intervention, consisting of lectures, role-playing with SPs and group debriefing. Unannounced SPs will repeat the assessment in all 24 sites following the intervention. The primary outcome is quality of PrEP counselling, including adherence to national guidelines and communication skills, scored on a checklist by SPs blinded to intervention assignment. An intention-to-treat (ITT) analysis will evaluate whether the intervention resulted in higher scores within intervention compared with control facilities, adjusted for baseline SP scores and accounting for clustering by facility. We hypothesise that the intervention will improve quality of PrEP counselling compared with standard of care. Results from this study will inform guidelines for PrEP delivery to AGYW in low-resource settings and offer a potentially scalable strategy to improve service delivery for this high-risk group.Ethics and disseminationThe protocol was approved by institutional review boards at Kenyatta National Hospital and University of Washington. An external advisory committee monitors social harms. Results will be disseminated through peer-reviewed journals and presentations.Trial registration numberNCT03875950
Effect of early cryoprecipitate transfusion versus standard care in women who develop severe postpartum haemorrhage (ACROBAT) in the UK: a protocol for a pilot cluster randomised trial
Authors: Green Laura , Daru Jahnavi , Dodds Julie , Gonzalez Carreras Francisco Jose , Lanz Doris , Zamora Javier , Pardo Llorente Maria del Carmen , Pérez Pérez Teresa , Sweeney Lorna , Thangaratinam Shakila , Thomas Amy , Khan Khalid Saeed 
Published: June 2020

IntroductionThe incidence of severe postpartum haemorrhage (PPH) that requires blood transfusion is on the increase. Fibrinogen levels have been shown to drop early and significantly during PPH, which is associated with worse outcomes. Early fibrinogen replacement could potentially improve outcomes. No studies have investigated the clinical impact of early cryoprecipitate transfusion in PPH. Prior to performing a full-scale trial, a pilot study is needed to determine feasibility of the intervention and recruitment.MethodsACROBAT is a cluster-randomised pilot study with a qualitative evaluation. Four large London maternity units are randomised to either the intervention or control group. The intervention group will adapt their major obstetric haemorrhage procedures to administer cryoprecipitate early for primary PPH. The control group will retain their standard of care.We include women at >24 weeks gestation who are actively bleeding within 24 hours of delivery and for whom transfusion of red blood cells (RBCs) has been started. We exclude women who decline blood transfusions in advance or have inherited Factor XIII or fibrinogen deficiency. Due to the emergency nature of the intervention, informed consent for administering the intervention is waived.The primary objective is to assess the feasibility of administering cryoprecipitate within 90 min of RBC request, as compared with standard treatment where cryoprecipitate is given later or not at all. Secondary objectives include the feasibility of recruitment and data collection, reasons for and barriers to consent, preliminary maternal clinical outcomes, identification of the optimal infrastructure pathways for study delivery, and acceptability of the intervention and outcomes.Ethics and disseminationThe trial has approvals from the London—Brighton & Sussex Research Ethics Committee (ref. 18/LO/2062), the Confidentiality Advisory Group (ref. 18/CAG/0199) and Health Research Authority (IRAS number 237959). Data analysis and publication of manuscripts will start in Q3 2020.Trial registration numberISRCTN12146519.
Ankle osteoarthritis and its association with severe ankle injuries, ankle surgeries and health-related quality of life in recently retired professional male football and rugby players: a cross-sectional observational study
Authors: Paget Liam D. A. , Aoki Haruhito , Kemp Simon , Lambert Mike , Readhead Clint , Stokes Keith A , Viljoen Wayne , Reurink Gustaaf , Tol Johannes L , Kerkhoffs Gino M M J , Gouttebarge Vincent 
Published: June 2020

ObjectivesTo determine (1) the prevalence of ankle osteoarthritis (OA) among former professional football and rugby players, (2) assess the association between ankle injuries or ankle surgeries with ankle OA, and (3) compare the mental and physical quality of life (QoL) between former professional football and rugby players with and without OA.MethodsWe conducted a questionnaire-based observational study with a cross-sectional design. Former professional football and rugby players were recruited by the Football Players Worldwide and the International Rugby Players. Information concerning ankle OA, sustained ankle injuries and ankle surgeries was gathered (medical record or most recent medical professional). Health-related QoL was assessed using the Patient-Reported Outcomes Measurement Information System (PROMIS) physical and mental health scores.ResultsOverall, 553 former professional football (n=401) and rugby (n=152) players were enrolled in the study (response rate of 56%). Ankle OA prevalence among former professional football and rugby players was 9.2% and 4.6%, respectively. Football players were more likely to suffer from ankle OA following every ankle injury and/or surgery. Football and rugby players with ankle OA had similar PROMIS physical and mental health scores to the norm for the general population.ConclusionFormer professional football and rugby players had higher ankle OA prevalence than the general population (3.4%). Football players are more likely to suffer from ankle OA following every ankle injury and/or surgery. No clinically relevant difference was seen for physical or mental health-related QoL among football and rugby players. Preventive measures for ankle injuries are recommended.