bluuebunny/crossref_metadata_2025_split huggingface dataset:
İNFRARENAL PERİFERİK ARTER HASTALIĞINDA KLİNİK MUAYENE, BİLGİSAYARLI TOMOGRAFİK ANJİOGRAFİ VE DİGİTAL SUBTRACTİON ANJİOGRAFİ BULGULARININ DEĞERLENDİRİLMESİ
Authors: YILDIRIM Murat , ÇELİK Ersin , ÖCAL Ahmet 
Published: October 2020

Bu çalışmanın amacı İnfrarenal periferik arter hastalığının
değerlendirilmesinde klinik muayene, BT Anjiografi
ve DSA bulgularının karşılaştırılmasıdır.
Gereç ve Yöntem
Bu çalışma Ocak 2013-Şubat 2014 tarihleri arasında,
Süleyman Demirel Üniversitesi Tıp Fakültesi Kalp ve
Damar Cerrahisi Anabilim Dalında retrospektif olarak
gerçekleştirildi. Çalışmaya yaşları 41-93 (ortalama
yaş; 63,83±12,75) arasında değişen, alt ekstremite arteriyel
semptomları olan 49 hasta (7 kadın, 42 erkek)
dahil edildi. Hastalara Digital Subtraction Anjiografi ve
128 multidedektörlü BT anjiyografi ile alt ekstremite
anjiyogramları çekildi ve bu iki yöntem karşılaştırıldı.
Bulgular
BT anjiyografi ve DSA sonuçlarında periferik arter
hastalığının alt ekstremitede değerlendirilmesi açısından
istatistiksel olarak anlamlı bir fark bulunmadı (p
0.05). DSA ve BT anjiografi görüntülerinde belirlenen
darlık yüzdesi ile AB indeks ve kladikasyo ölçümleri
arasında negatif yönde anlamlı korelasyon saptandı.
Sonuç
Periferik arter hastalığının alt ekstremitede değerlendirilmesinde
BT angiografi, DSA’ya alternatif bir görüntüleme
yöntemi olarak düşünülebilir.
Anahtar Kelimeler: Bacak kol İndeksi, Bilgisayarlı
tomografi anjiyografi, Digital Substrakt Anjiografi, İnfrarenal
periferik arteriyel hastalık, Kladikasyo intermittant
A rare deformity of the brain, accompanied by incomplete separation of the cerebral hemispheres
Authors: Osipov V. P. 
Published: October 2020

The case, the description of which will be the subject of this article, belongs to the number of rare deformities of the central nervous system, presenting very sharp deviations from the normal type of brain development. The brain belongs to a stillborn premature fetus, which appeared in the light under the following conditions:
In the fall of 1895, S.P. A pregnant woman came to the Burgsk Clinical Military Hospital, stating that she felt the approach of childbirth, although she still had about a month to go; at the same time, she explained that she was serving in a tobacco factory, where three days ago she was hit in the stomach by a heavy bale that had fallen on her; soon after that she stopped feeling the fetal movement, and then labor pains began. The objective examination of the woman in labor, carried out in the maternity ward, confirmed the death of the fetus, and a few hours later, the premature birth was followed by the dead fetus.
Descriptive study of clinical profile and outcome in patients of acute on chronic liver failure, at a tertiary care center in Northern India
Authors: Kumar Rakesh , Rana Vandana , Koshy Varghese , Gangadharan Vandana , Koshy George 
Published: October 2020

Background: Acute-on-chronic liver failure (ACLF) is a recently described syndrome that is characterized by abrupt deterioration in patients with chronic liver disease (CLD) and has high short-term mortality. The aim of this study was to describe the clinical profile, causes and outcomes of ACLF at a tertiary care centre in Northern India.Methods: In this descriptive study of 50 consecutive patients, were included, between August 2015 to January 2018, who were admitted and diagnosed as ACLF as defined by APASL. Causes of acute precipitating event and CLD and outcomes were assessed.Occurrence and severity of organ failure was also assessed.Results: 48 (96 %) were males and 2 (4%) were females with male to female ratio was 24:1. The mean age of male and female subjects was similar, 40.7±9.9 years and 39.2±9.4 years respectively. The most common cause of CLD was alcohol in 50% cases and next most common cause was hepato-tropic viruses HBV infection in 20%, HCV in 6% cases and there was unknown cause in 12 % cases. The most common precipitating factor of acute decompensation was alcohol in 50% cases, hepatotropic viruses in 30% cases. Excluded sepsis and GI bleed as precipitating events. The combined mortality at the end of 1-month and 3-months, in our study was 60%. CLIF-SOFA score was found to be the most reliable scoring system to discriminate between survivors and non survivors. Conclusions: Alcohol was the commonest precipitating cause of ACLF. Organ failures (OFs) are independently predictive of mortality.
PRAGMATICS OF SPEECH STYLE IN BUSINESS COMMUNICATION AS A TOOL FOR DEVELOPMENT OF MODERN BUSINESS LINGUISTICS
Authors: Shokhayeva Karlygash , Kalniyazova Ainur , Aryn Yerzhan , Assembaiuly Yerlan , Otegen Nuraly 
Published: October 2020

Purpose of the study: The study aims to identify, describe, systematize, and compare linguistic means expressing communicative and pragmatic meaning in determining their composition, semantics, and functions in the genres of law, order, and international agreement. The development of linguistic thought is characterized by an increasing interest in the functioning of linguistic units in speech, increased attention to the human factor in the language.
Methodology: A communicative-pragmatic approach described the transition from the study of genres as functional and stylistic types of text to their study as special expressions inherent in a certain area of communication. The authors used models of the relationship between linguistic units and their various associations with extra-linguistic situations of communication in a certain sphere of human activity.
Main Findings: The authors showed specifics of the representation of the value of the address in an official speech, establishes a repertoire of language means that realize the meaning of address in prescription genres, determines the dependence of the choice of the lexico-grammatical form of means of express the essence of addressing, forms the speech structure of styles.
Applications of this study: The work defines the specifics of the conditions of communication in the business sphere; revealed the communicative specificity of stereotyped role manifestations and speech behavior in terms of the functioning of oral and written genres, characteristic for speech communication in the professional sphere. The classification of speech genres is proposed primarily for the business area.
Novelty/Originality of this study: The novelty is determined by the object of research and the enterprise's attempt to make a comprehensive description of the genres of speech communication in business from the position of communicative-pragmatic approach. The communicative-pragmatic method in modern linguistics has updated the research of the specifics of speech communication and language support of speech communication in various spheres of human activity.
Construction processes of roof structures: a systematic review
Authors: Pilz Thaisa Lana , Scheuer Mayara , Maceno Marcell Mariano Corrêa , Genaro Thalyta , Sotsek Nicolle Christine 
Published: October 2020

Despite the fact that the construction industry in Brazil is traditionally recognized for the use of craft construction techniques, in the last few years, there has been a growth in the search for new materials, processes, and technologies for this segment. This is mainly due to the great environmental impact that this sector causes. Based on this context, this article aimed to map the constructive processes of existing roofs in the literature, to raise its advantages, disadvantages and previous cases. To achieve this aim, the systematic review method based on three phases – research questions, selection of documents and classification of selected documents, and the 5W2H quality tool were used. Thus, this research could contribute to the literature on this topic, as well as encourage the idealization of new ideas of roof construction processes.
Students’ reading interest in biology learning model based on remap CIRC, GI and TGT
Authors: Hayati Nur , Zubaidah Siti , Mahanal Susriyati 
Published: October 2020

This study aims to determine the differences in students' reading interest in biology learning models based on remap CIRC, GI, and TGT. It is a quasi-experiment implemented in Public High School N of Malang, Indonesia and Public High School S of Malang, Indonesia in the odd semester of 2014/2015. The research population was all students of 10th grade of Public High School of Malang, Indonesia. The sampling technique was random sampling. The research sample consisted of 10th-grade science 1 of Public High School N of Malang, Indonesia, 10th-grade science 2 of Public High School N of Malang Indonesia, and 10th-grade science 1 of Public High School S of Malang, Indonesia as an experiment group; and 10th-grade science 3 of Public High School N of Malang, Indonesia as a control group. The analysis was carried out in a quantitative. The result showed that the CIRC remapping learning model had the greatest influence on students' reading interest compared to GI and TGT. The students’ reading interest scores using remap CIRC, GI, and TGT models were 82.90, 76.23, and 80.49. Remap CIRC, GI, and TGT model should be applied in biology learning because it can empower students' reading interest.
Gastrointestinal Tract Disorders in COVID-19 Infected Children
Authors: Popova R. V. , Ruzhentsova T. A. , Khavkina D. A. , Chukhlyaev P. V. , Garbuzov A. A. , Meshkova N. A. 
Published: October 2020

Objective of the work was to investigate the peculiarities of gastrointestinal tract disorders in children with coronavirus disease caused by SARS-CoV-2 virus.Materials and methods. We have analyzed the frequency, terms of emergence, duration and character of gastrointestinal disorders on the basis of medical records of 36 children receiving the treatment for community-acquired pneumonia of coronavirus etiology (positive for SARS-CoV-2 virus) in the children’s infectious disease department of Moscow State Clinical Hospital, Mytishchi. The majority of patients had moderate form of the disease (97 %), severe cases were not registered. The age range of the children – 8 months to17 years old. All patients were subjected to supplementary examination on Day 1 in accordance with the current recommendations. Children were treated in hospital settings for 8–15 days. Assessment of clinical status was performed at least once a day over the stated period, supplementary survey – at least once in a week, upon indications – more frequently. SARSCoV-2 virus was identified using polymerase chain reaction. All patients received standard therapy in compliance with advanced methodological recommendations, upon indications – other pharmaceutical products.Results and discussion. Gastro-intestinal disorders in 23 children (64 %) emerged on Day 4–5, in 8 children (22 %) – before the start of the treatment; they lasted 3–5 days. In most of the patients diarrhea (64 %) and stomachaches (57 %) were observed. 67 % of the children demonstrated other symptoms indicative of gastrointestinal dysfunction. The disorders were characteristic for most of the children hospitalized with community-acquired pneumonia caused by SARS-CoV-2 virus. The symptoms are contained when the main course of therapy is conducted, indicated for treatment of COVID-19, and additional therapy recommended for management of gastro-intestinal infections is performed.
Electro-Optical Analysis of Cell Viability of Tularemia Microbe Vaccine Strain
Authors: Volokh O. A. , Borisova S. V. , Bibikov D. N. , Kuznetsova E. M. , Samokhvalova Yu. I. , Avdeeva N. G. , Komissarov A. V. , Nikiforov A. K. 
Published: October 2020

Objective: to study the possibility of applying electro-optical analysis for the assessment of cell viability of tularemia microbe vaccine strain at different stages of experimental live tularemia vaccine production.Materials and methods. The research object was a cell culture of Francisella tularensis 15 NIIEG. Investigations were carried out at all stages of experimental live tularemia vaccine (ELTV) manufacturing according to an advanced technology: cultivation, concentrating, diafiltration, mixing with drying media, stabilization, and storage (two-year period of observation). Electro-optical analysis by the parameter “polarizability anisotropy” of bacterial cell was conducted with the help of EloTrace (EloSystems, Germany). Total concentration of cells was evaluated using density metering at 590 nm and spectrometry – at 650 nm. Viability was assessed through inoculation of plates with FT-agar.Results and discussion. The experiment has demonstrated that the change in polarizability anisotropy of the cell at the frequencies of 900 kHz and 2100 kHz, reflecting the state of cytoplasm and cytoplasmic membrane, respectively, is the earliest response to changes in vital indicators of bacterial culture in the process of cultivation. Thereby, the decrease in viability of F. tularensis cells occurrs well before the decrease in cell concentration. We have shown the preservation of viability of F. tularensis 15 NIIEG cells at all stages of experimental live tularemia vaccine production. Electro-optical analysis allows for registering the changes in vital parameters of microorganism cells in real-time mode, while the assessment of viability applying bacteriological method takes up to 5 days. Different stages of tularemia vaccine manufacturing have impact on the vital indicators of F. tularensis cells, and electro-optical analysis is a prospect method of control of such parameter as “Specific activity (the number of live microbial cells)”.
Qualitative Indicators of Experimental Brucellosis Antigen Preparations Designed for Cellular Tests in vitro
Authors: Kurcheva S. A. , Kovalev D. A. , Ponomarenko D. G. , Siritsa Yu. V. , Kostyuchenko M. V. , Koshkid’ko A. G. , Zharnikova I. V. , Rakitina E. L. , Logvinenko O. V. , Zhirov A. M. 
Published: October 2020

In order to develop the most diagnostically informative methods for carrying out antigen-stimulated cellular tests in vitro a careful selection of stimulating agent (antigen) is required, possessing an adequate activating potential and providing specificity of the reaction.Objective of the study was to identify the qualitative indicators of experimental batches of brucellosis antigen preparations designed for cellular tests in vitro.Materials and methods. Initially we produced antigen complexes of brucellosis microbe on the basis of the vaccine strains of three epidemically significant Brucella species (B. abortus, B. melitensis, B. suis). Quantitative determination of WsAg and PPBC proteins of experimental preparation series was performed applying capillary electrophoresis. Qualitative composition was assessed through ion exchange liquid chromatography with refractometric detection.Results and discussion. We have specified physical-chemical features, investigated chromatographic profiles and composition of protein fractions, as well as tried the produced experimental batches of brucellosis antigen preparations. After analyzing the defined protein and polysaccharide composition of the obtained WsAg samples, one can conclude that WsAg preparation cannot be used for cellular tests as the probability of non-specific lymphocyte reaction manifestation in vitro was experimentally proven. By contrast, complex brucellosis antigen preparation PPBC has an expressed specific activity and specificity under in vitro conditions and the prospects to be used when developing methodological approaches for laboratory diagnosis of brucellosis and assessment of de facto immunity rate in risk contingents after vaccination. The obtained parameters will allow for proper quality provision when manufacturing the developed experimental PPBC preparation designed for cellular tests in vitro, taking into account modern validation and standardization regulations.
Failure of the Femoral Component in a Cemented Total Knee Replacement
Authors: Kropelnicki Anna , Platt W.J. 
Published: October 2020

Case:
The usual mechanism of failure of a total knee arthroplasty is aseptic loosening of the tibial component. We present a case of an atraumatic late failure by fracture of the femoral component in an active 83-year-old and review the very small number of similar cases within the literature.

Conclusion:
Although it is difficult to draw firm conclusions on such a rare presentation, it appears the heavy-set, active man may be at risk of a femoral component fracture in the long-term. This case also raises an important question about diligence in cementing techniques for the femoral component.
Antimicrobial resistance among GLASS pathogens in conflict and non-conflict affected settings in the Middle East: A systematic review
Authors: Truppa Claudia , Abo-Shehada Mahmoud N. 
Published: October 2020

Abstract
Background: In spite of the evident general negative effects of armed conflict on countries’ health systems and populations’ health outcomes, little is known about similar impacts of conflicts on the spread of antimicrobial resistances (AMR). This review was to address this evidence gap and describe:1. Patterns of AMR in the Middle East (ME) and resistance profiles of pathogens included in the Global AMR Surveillance System (GLASS) supported by the World Health Organization;2. Differences in proportions of AMR isolates between conflict and non-conflict countries. Methods: A systematic literature review was conducted following PRISMA guidelines and searching five electronic databases. Subject heading and free text were searched for “antimicrobial resistances” and “Middle East”, to identify observational studies on AMR published from January 2011 to June 2018. Data were extracted from included articles on a predefined set of variables. Percentages of AMR were analysed as median and interquartile ranges. Risk of bias was assessed using the Newcastle-Ottawa Scale. Results: A total of 132 articles met the inclusion criteria. Included studies showed heterogeneity in study design, laboratory methods and standards for interpretation of results, and an overall high risk of bias. Main findings were the following:1. High proportions of carbapenem resistance in Acinetobacter spp. (median 74.2%: range), and both carbapenem resistance (median 8.1% and 15.4% for E. coli and K. pneumoniae respectively) and ESBL-production (median 32.3% and 27.9% for E. coli and K. pneumoniae respectively) amongst Enterobacteriaceae. S. aureus isolates showed a median methicillin resistance percentage of 45.1%, while vancomycin resistance was almost absent. A median of 50% of the strains of S. pneumoniae showed non-susceptibility to penicillin. 2. Similar trends were observed in conflict and non-conflict affected countries.Conclusions: There is a lack of standardization in the methodological approach to AMR research in the Middle East. The proportion of antibiotic resistances among specific GLASS pathogens is high, particularly among Acinetobacter spp.
Development and evaluation of an online education tool on Attention Deficit Hyperactivity Disorder for General Practitioners: the important contribution of co-production
Authors: French Blandine , Daley David , Perez-Vallejos Elvira , Sayal Kapil , Hall Charlotte 
Published: October 2020

Abstract
Background: Attention deficit hyperactivity disorder (ADHD) is underdiagnosed in the UK and the assessment and diagnosis pathway often involves a general practitioner (GP) referral to secondary care services. GPs’ levels of knowledge and understanding about ADHD is often a significant barrier in patients accessing care. The development of an online education ressource could improve GPs knowledge of ADHD and optimise appropriate referrals. Involving end-users in co-creating interventions may enhance their clinical utility and impact in routine clinical practice. However, there is limited published evidence describing how to meaningfully involve stakeholders in both the design and development components of co-production. Method : We report a step wise, co-production approach towards developing an online ADHD education intervention for GPs. Preparatory work highlighted the relevant topics to be included in the intervention, from which educational videos were then developed. Workshops were then conducted with GPs, leading to further refinement of the video content and subsequently the final intervention. A pilot usability study (n=10 GPs) was then conducted to assess the intervention’s acceptability, feasibility and accessibility. Results : The development of the online intervention was greatly facilitated by the involvement of GPs. Having a co-production development process ensured the consistent adaptation of the intervention to meet GPs’ needs. The usability study showed that the content of the intervention was suitable, easily accessible, engaging and delivered at an acceptable level of intensity, validating the development approach taken. Conclusion : While further studies are needed to evaluate the efficacy of the developed intervention, preliminary findings demonstrated that it was acceptable and well received. The importance of co-development was highlighted in developing an intervention that addresses specific needs for GPs. This development approach may be useful for other researchers and developers of clinical interventions.
Germline Variation Networks in the PI3K/AKT Pathway Corresponding to Familial High-incidence Lung Cancer Pedigrees
Authors: Lin Huan , Zhang Gong , Zhang Xu-chao , Lian Xin-lei , Zhong Wen-zhao , Su Jian , Chen Shi-liang , Wu Yi-long 
Published: October 2020

Abstract
Background: There were scarcely germline variants of familial lung cancer (LC) identified. We conducted an study with whole-exome sequencing of pedigrees with familial lung cancer to analyze the potential genetic susceptibility. Methods: Probands with the highest hereditary background were identified by our large-scale epidemiological study and five ones were enrolled as a learning set. The germline SNPs (single-nucleotide polymorphisms) of other five similar probands, four healthy individuals in the formerly pedigrees and three patients with sporadic LC were used as a validation set, controlled by three healthy individuals without family history of any cancer. The network of mutated genes was generated using STRING-DB and visualized using Cytoscape. Results: Specific and shared somatic mutations and germline SNPs were not the shared cause of familial lung cancer. However, individual germline SNPs showed distinct protein-protein interaction network patterns in probands versus healthy individuals and patients with sporadic lung cancer. SNP-containing genes were enriched in the PI3K/AKT pathway. These results were validated in the validation set. Furthermore, patients with familial lung cancer were distinguished by many germline variations in the PI3K/AKT pathway by a simple SVM classification method. It is worth emphasizing that one person with many germline variations in the PI3K/AKT pathway developed lung cancer during follow-up. Conclusions: The phenomenon that the enrichments of germline SNPs in the PI3K/AKT pathway might be a major predictor of familial susceptibility to lung cancer.