bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bidirectional interactions between host social behaviour and parasites arise through ecological and evolutionary processes
Authors: Hawley Dana M. , Gibson Amanda K. , Townsend Andrea K. , Craft Meggan E. , Stephenson Jessica F. 
Published: October 2020

AbstractAn animal's social behaviour both influences and changes in response to its parasites. Here we consider these bidirectional links between host social behaviours and parasite infection, both those that occur from ecologicalvsevolutionary processes. First, we review how social behaviours of individuals and groups influence ecological patterns of parasite transmission. We then discuss how parasite infection, in turn, can alter host social interactions by changing the behaviour of both infected and uninfected individuals. Together, these ecological feedbacks between social behaviour and parasite infection can result in important epidemiological consequences. Next, we consider the ways in which host social behaviours evolve in response to parasites, highlighting constraints that arise from the need for hosts to maintain benefits of sociality while minimizing fitness costs of parasites. Finally, we consider how host social behaviours shape the population genetic structure of parasites and the evolution of key parasite traits, such as virulence. Overall, these bidirectional relationships between host social behaviours and parasites are an important yet often underappreciated component of population-level disease dynamics and host–parasite coevolution.
Reversing retirement frontiers in the spaces of post-socialism: active ageing through migration for work
Authors: Lulle Aija 
Published: October 2020

AbstractThis paper reworks the notion of active ageing through analysis of a case which reverses the retirement-migration nexus – people in the post-socialist realm who approach retirement age and then migrate to begin a new working life. They are thereby introducing a new and complex arrangement to the general concept of ‘international retirement migration’. In the post-socialist world, new retirement migration frontiers emerge in the context of a severe weakening of welfare systems. I illustrate this case with data from long-term research with ageing Latvian migrant women to the United Kingdom and the Nordic countries. Even those whose old-age pensions are more or less adequate nevertheless seek temporary employment and new cultural experiences abroad. However, the dominant trend has been towards the pauperisation of older parents and those approaching retirement age due to the significant decline in state welfare. This case of many older-age Latvians whode factocannot retire due to low disposable income reveals ‘reverse frontiers of retirement’: working as long as they can, pushing their personal geographical frontiers outward by emigrating for work and making national frontiers more porous through transnational practices. Conceptually and geographically, the research holds relevance for a wider discussion of trends and contextual factors in other post-Soviet and post-socialist countries with increasing diversities among retirees.
Social media use as a predictor of handwashing during a pandemic: evidence from COVID-19 in Malaysia
Authors: Zhang Stephen X. , Graf-Vlachy Lorenz , Looi Kim Hoe , Su Rui , Li Jizhen 
Published: October 2020

Abstract
Although handwashing is an effective way to prevent infections, there is scarce evidence on predictors of handwashing during a pandemic. This paper aims to identify behavioural and demographic predictors of handwashing. The study surveyed 674 adults in Malaysia in May 2020 regarding whether the time spent on social media predicted handwashing contingent on gender and number of children. More time spent on social media was positively associated with handwashing for males with three or more children. However, for males without children, social media use was negatively associated with handwashing. The association was not significant for males with one or two children. For females, more time spent on social media was significantly linked to more handwashing only for females with one child. Gender, a traditional predictor of handwashing, was a useful predictor only for those who spent more than three hours per day on social media and had at most one child. Number of children was a novel negative predictor for males who did not use social media and who averaged one hour per day on social media, a positive predictor for males who spent lots of time on social media, but not a predictor for females. In sum, social media use predicts handwashing, and is thus a helpful variable for use in targeted health communication during a pandemic – particularly through social media. Further, more conventional predictors like gender and number of children exhibit contingency effects with social media use.
Clinical characteristics of COVID-19 with cardiac injury: a systematic review and meta-analysis
Authors: Zeng Linwen , Wang Shihui , Cai Jianing , Sun Shaoqing , Wang Suhuai , Li Jingjie , Sun Lin 
Published: October 2020

Abstract

Objectives
Cardiac injury is associated with poor prognosis of 2019 novel coronavirus disease 2019 (COVID-19), but the risk factors for cardiac injury have not been fully studied. In this study, we carried out a systematic analysis of clinical characteristics in COVID-19 patients to determine potential risk factors for cardiac injury complicated COVID-19 virus infection.

Methods
We systematically searched relevant literature published in Pubmed, Embase, Europe PMC, CNKI and other databases. All statistical analyses were performed using STATA 16.0.

Results
We analysed 5726 confirmed cases from 17 studies. The results indicated that compared with non-cardiac-injured patients, patients with cardiac injury are older, with a greater proportion of male patients, with higher possibilities of existing comorbidities, with higher risks of clinical complications, need for mechanical ventilation, ICU transfer and mortality. Moreover, C-reactive protein, procalcitonin, D-dimer, NT-proBNP and blood creatinine in patients with cardiac injury are also higher while lymphocyte counts and platelet counts decreased. However, we fortuitously found that patients with cardiac injury did not present higher clinical specificity for chest distress (P = 0.304), chest pain (P = 0.334), palpitations (P = 0.793) and smoking (P = 0.234). Similarly, the risk of concomitant arrhythmia (P = 0.103) did not increase observably either.

Conclusion
Age, male gender and comorbidities are risk factors for cardiac injury complicated COVID-19 infection. Such patients are susceptible to complications and usually have abnormal results of laboratory tests, leading to poor outcomes. Contrary to common cardiac diseases, cardiac injury complicated COVID-19 infection did not significantly induce chest distress, chest pain, palpitations or arrhythmias. Our study indicates that early prevention should be applied to COVID-19 patients with cardiac injury to reduce adverse outcomes.
Cooperation, technical education and politics in early agricultural policy in Catalonia (1914–24)
Authors: Planas Jordi 
Published: October 2020

AbstractAfter the crisis of the late nineteenth century, the role of the state in European agriculture expanded to many new areas: education and technical innovation; commercial policies and market regulations; farm support policies, and sometimes interventions in property rights. The development of these policies was a difficult and costly process, without the intervention of intermediary organisations like agricultural cooperatives and farmers’ associations. This article analyses the early agricultural policy in Catalonia (Spain) and the role of cooperatives in its implementation. It argues that this regional case was quite exceptional in the early twentieth-century Spanish context, where state intervention in agriculture was extremely limited. In 1914, an autonomous government was set up in Catalonia, and a modern agricultural policy was introduced in which technical education and cooperatives played a crucial role, as well as politics. The agricultural policy promoted and developed by the Catalan government was part of a state-building project based on a regionalist ideology.
Rare cause of dynamic aortic obstruction in pulmonary atresia, ventricular septal defect, and major aortopulmonary collateral arteries: a case report
Authors: Correia-Costa Ana , Casanova Jorge , Granja Sofia 
Published: October 2020

AbstractA 2-month-old infant with pulmonary atresia, ventricular septal defect, and major aortopulmonary collateral arteries developed an aneurysmatic elongation of the tricuspid valve tissue that partially closed and dynamically protruded through the ventricular septal defect, beneath the aortic valve. This rare finding caused dynamic left ventricle outflow tract obstruction and recurrent cardiac arrests and ultimately required surgical intervention.
Neural circuits of anxiolytic and antidepressant pherine molecules
Authors: Monti Louis , Liebowitz Michael R. 
Published: October 2020

AbstractIn this review, we describe proposed circuits mediating the mechanism of action of pherines, a new class of synthetic neuroactive steroids with demonstrated antianxiety and antidepressant properties, that engage nasal chemosensory receptors. We hypothesize that afferent signals triggered by activation of these peripheral receptors could reach subgroups of olfactory bulb neurons broadcasting information to gamma-aminobutyric acid (GABAergic) and corticotropin-releasing hormone (CRH) neurons in the limbic amygdala. We propose that chemosensory inputs triggered by pherines project to centrolateral (CeL) and centromedial (CeM) amygdala neurons, with downstream effects mediating behavioral actions. Anxiolytic pherines could activate the forward inhibitory GABAergic neurons that facilitate the release of neuropeptide S (NPS) in the locus coeruleus (LC) and GABA in the bed nucleus of the stria terminalis (BNST) and inhibit catecholamine release in the LC and ventral tegmental area (VTA) leading to rapid anxiolytic effect. Alternatively, antidepressant pherines could facilitate the CRH and GABAergic neurons that inhibit the release of NPS from the LC, increase glutamate release from the BNST, and increase norepinephrine (NE), dopamine (DA), and serotonin release from the LC, VTA, and raphe nucleus, respectively. Activation of these neural circuits leads to rapid antidepressant effect. The information provided is consistent with this model, but it should be noted that some steps on these pathways have not been demonstrated conclusively in the human brain.
Improving the Use of Calibrated Language in U.S. Climate Assessments
Authors: Crimmins Allison 
Published: October 2020

Key Points

Despite improvements to better characterize risk in climate assessments, scientists' certainty in findings is often misinterpreted
U.S. climate assessments often report high confidence and likelihood findings and rarely report low certainty, potentially severe impacts
Alternative representations of calibrated language may alleviate confusion caused by the common use of colloquial likelihood terms
Warmer and Drier Fire Seasons Contribute to Increases in Area Burned at High Severity in Western US Forests From 1985 to 2017
Authors: Parks S. A. , Abatzoglou J. T. 
Published: October 2020

AbstractIncreases in burned area across the western United States (US) since the mid‐1980s have been widely documented and linked partially to climate factors, yet evaluations of trends in fire severity are lacking. Here we evaluate fire severity trends and their interannual relationships to climate for western US forests from 1985 to 2017. Significant increases in annual area burned at high severity (AABhs) were observed across most ecoregions, with an overall eightfold increase in AABhs across western US forests. The relationships we identified between the annual fire severity metrics and climate, as well as the observed and projected trend toward warmer and drier fire seasons, suggest that climate change will contribute to increased fire severity in future decades where fuels remain abundant. The growing prevalence of high‐severity fire in western US forests has important implications to forest ecosystems, including an increased probability of fire‐catalyzed conversions from forest to alternative vegetation types.
Using Thermal Springs to Quantify Deep Groundwater Flow and Its Thermal Footprint in the Alps and a Comparison With North American Orogens
Authors: Luijendijk Elco , Winter Theis , Köhler Saskia , Ferguson Grant , von Hagke Christoph , Scibek Jacek 
Published: October 2020

AbstractThe extent of deep groundwater flow in mountain belts and its thermal effects are uncertain. Here, we use a new database of discharge, temperature, and composition of thermal springs in the Alps to estimate the extent of deep groundwater flow and its contribution to the groundwater and heat budget. The results indicate that thermal springs are fed exclusively by meteoric water and make up 0.1% of the total groundwater budget. Spring water circulates on average to a depth of at least 2 km. The net heat extracted from the subsurface equals 1% of the background heat flow, which equals an average thermal footprint of 7 km2. Cooling by downward flow and heating by upward flow are three and two times higher than the net heat flow, respectively. Comparison with North American orogens shows that hydrothermal activity is higher in areas with high relief or areas under extension.
Coupling of the Subpolar Gyre and the Overturning Circulation During Abrupt Glacial Climate Transitions
Authors: Klockmann M. , Mikolajewicz U. , Kleppin H. , Marotzke J. 
Published: October 2020

AbstractWe present a mechanism for self‐sustained ocean circulation changes that cause abrupt temperature changes over Greenland in a multimillennial climate model simulation with glacial CO2 concentrations representative of Marine Isotope Stage 3. The Atlantic meridional overturning circulation (AMOC) and the subpolar gyre (SPG) oscillate on millennial time scales. When the AMOC is strong, the SPG is weak and contracted; when the AMOC is weak, the SPG is strong and extensive. The coupling between the two systems via wind‐driven and density‐driven feedbacks is key to maintaining the oscillations. The SPG controls the transport of heat and salt into the deep‐water formation sites and thus controls the AMOC strength. The strength and location of the deep‐water formation affect the density‐driven part of the SPG and thus control the mean strength and extent of the SPG. This mechanism supports the hypothesis that coupled ocean‐ice‐atmosphere interactions could have triggered abrupt glacial climate change.
How Does El Niño–Southern Oscillation Change Under Global Warming—A First Look at CMIP6
Authors: Fredriksen Hege‐Beate , Berner Judith , Subramanian Aneesh C. , Capotondi Antonietta 
Published: October 2020

AbstractThe latest generation of coupled models, the sixth Coupled Models Intercomparison Project (CMIP6), is used to study the changes in the El Niño–Southern Oscillation (ENSO) in a warming climate. For the four future scenarios studied, the sea surface temperature variability increases in most CMIP6 models, but to varying degrees. This increase is linked to a weakening of the east‐west temperature gradient in the tropical Pacific Ocean, which is evident across all models. Just as in previous generations of climate models, we find that many characteristics of future ENSO remain uncertain. This includes changes in dominant time scale, extratropical teleconnection patterns, and amplitude of El Niño and La Niña events. For models with the strongest increase in future variability, the majority of the increase happens in the Eastern Pacific, where the strongest El Niño events usually occur.
A Methodology for Estimation of Hourly‐Monthly Stochastic Trend Characteristics of Midlatitude Ionosphere
Authors: Arikan F. , Koroglu O. 
Published: October 2020

AbstractSpatiotemporal variability of ionosphere poses a major challenge in characterization of observable parameters, critical frequency of F2 layer (foF2), maximum ionization height (hmF2), total electron content (TEC), and slab thickness. The nature of the multiscale space‐time variability of ionosphere can be modeled as a random field. In this study, as a first step in random field modeling of the trend, hourly‐monthly parametric probability density functions (PPDF) of foF2, hmF2, slab thickness, and TEC are obtained using IONOLAB‐PDF method for three midlatitude stations (namely, Juliusruh, Pruhonice, and Rome) for low, moderate, and high solar activity years of 2009, 2012, and 2014, respectively. foF2 and hmF2 are obtained from ionosondes. TEC is estimated from dual‐frequency Global Positioning System (GPS) receivers. It is observed that hourly‐monthly PPDFs of all ionospheric parameters at the three midlatitude stations can best be represented by lognormal and Weibull distributions. The estimates of mean and standard deviations of hourly‐monthly PPDFs indicate that the spatiotemporal stochastic trend variation of the midlatitude ionosphere differs in terms of foF2 and GPS‐TEC. The hourly‐monthly PPDF of foF2 represents all major anomalies as well as seasonal and hourly trends, whereas those of GPS‐TEC is highly dependent on solar activity level and latitude. The general statistical trend of hmF2 is anticorrelated with foF2 as expected. The mean of hourly‐monthly PPDF of slab thickness is around 400 km in 2012 and 2014 for all stations between 0200 UT and 1600 UT.
Using Deep Learning to Improve Ensemble Smoother: Applications to Subsurface Characterization
Authors: Zhang Jiangjiang , Zheng Qiang , Wu Laosheng , Zeng Lingzao 
Published: October 2020

AbstractEnsemble smoother (ES) has been widely used in various research fields to reduce the uncertainty of the system‐of‐interest. However, the commonly adopted ES method that employs the Kalman formula, that is, ES(K), does not perform well when the probability distributions involved are non‐Gaussian. To address this issue, we suggest to use deep learning (DL) to derive an alternative analysis scheme for ES in non‐Gaussian data assimilation problems. Here we show that the DL‐based ES method, that is, ES(DL), is more general and flexible. In this new scheme, a high volume of training data is generated from a relatively small‐sized ensemble of model parameters and simulation outputs, and possible non‐Gaussian features can be preserved in the training data and captured by an adequate DL model. This new variant of ES is tested in two subsurface characterization problems with or without the Gaussian assumption. Results indicate that ES(DL) can produce similar (in the Gaussian case) or even better (in the non‐Gaussian case) results compared to those from ES(K). The success of ES(DL) comes from the power of DL in extracting complex (including non‐Gaussian) features and learning nonlinear relationships from massive amounts of training data. Although in this work we only apply the ES(DL) method in parameter estimation problems, the proposed idea can be conveniently extended to analysis of model structural uncertainty and state estimation in real‐time forecasting problems.
Wnt5a enhances proliferation of chronic lymphocytic leukemia and ERK1/2 phosphorylation via a ROR1/DOCK2-dependent mechanism
Authors: Hasan Md Kamrul , Ghia Emanuela M. , Rassenti Laura Z. , Widhopf George F. , Kipps Thomas J. 
Published: October 2020

AbstractPatients with chronic lymphocytic leukemia (CLL) have high plasma-levels of Wnt5a, which can induce phosphorylation of ERK1/2 and enhance CLL-cell proliferation. Such effects could be inhibited by treatment with an ERK1/2 inhibitor, ERK1/2-specific siRNA, or cirmtuzumab, an anti-ROR1 mAb. The CLL-derived line, MEC1, expresses Wnt5a, but not ROR1. MEC1 cells transfected to express ROR1 (MEC1-ROR1) had higher levels of phosphorylated ERK1/2 than parental MEC1, or MEC1 transfected with ROR1ΔPRD, a truncated ROR1 lacking the cytoplasmic proline-rich domain (PRD), or ROR1P808A a mutant ROR1 with a P→A substitution at 808, which is required for complexing with the Rac-specific-guanine-nucleotide-exchange factor DOCK2 upon stimulation with Wnt5a. We silenced DOCK2 with siRNA and found this repressed the capacity of Wnt5a to induce ERK1/2 phosphorylation in MEC1-ROR1 or CLL cells. CLL cells that expressed ROR1 had higher levels of phosphorylated ERK1/2 or DOCK2 than CLL cells lacking ROR1. Although we found ibrutinib could inhibit the phosphorylation of ERK1/2 and DOCK2 induced by B-cell-receptor ligation, we found that this drug was unable to inhibit Wnt5a-induced, ROR1-dependent phosphorylation of ERK1/2 or DOCK2. This study demonstrates that Wnt5a can induce activation of ERK1/2 and enhance CLL-cell proliferation via a ROR1/DOCK2-dependent pathway independent of BTK.
Irreversible electroporation plus allogenic Vγ9Vδ2 T cells enhances antitumor effect for locally advanced pancreatic cancer patients
Authors: Lin Mao , Zhang Xiaoyan , Liang Shuzhen , Luo Haihua , Alnaggar Mohammed , Liu Aihua , Yin Zhinan , Chen Jibing , Niu Lizhi , Jiang Yong 
Published: October 2020

AbstractImmunotherapy has limited efficacy against locally advanced pancreatic cancer (LAPC) due to the presence of an immunosuppressive microenvironment (ISM). Irreversible electroporation (IRE) can not only induce immunogenic cell death, but also alleviate immunosuppression. This study aimed to investigate the antitumor efficacy of IRE plus allogeneic γδ T cells in LAPC patients. A total of 62 patients who met the eligibility criteria were enrolled in this trial, then randomized into two groups (A: n = 30 and B: n = 32). All patients received IRE therapy and after receiving IRE, the group A patients received at least two cycles of γδ T-cell infusion as one course continuously. Group A patients had better survival than group B patients (median OS: 14.5 months vs. 11 months; median PFS: 11 months vs. 8.5 months). Moreover, the group A patients treated with multiple courses of γδ T-cell infusion had longer OS (17 months) than those who received a single course (13.5 months). IRE combined with allogeneic γδ T-cell infusion is a promising strategy to enhance the antitumor efficacy in LAPC patients, yielding extended survival benefits.ClinicalTrials.gov ID: NCT03180437.