bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is Peoperative Glenoid Bone Mineral Density A Risk Factor for Aseptic Glenoid Implant Loosening in Anatomic Total Shoulder Arthroplasty?
Authors: Mariaux Sandrine , Obrist Raphaël , Farron Alain , Becce Fabio , Terrier Alexandre 
Published: September 2020

Abstract
Background: Aseptic loosening of glenoid implants is the primary revision cause in anatomic total shoulder arthroplasty (aTSA). While supported by biomechanical studies, the impact of glenoid bone quality, more specifically bone mineral density (BMD), on aseptic glenoid loosening remains unclear. We hypothesized that lower preoperative glenoid BMD was associated with and a risk factor for aseptic glenoid implant loosening in aTSA.Methods: We retrospectively included 93 patients (69 females and 24 males; mean age, 69.2 years) who underwent preoperative non-arthrographic shoulder computed tomography (CT) scans and aTSA between 2002 and 2014. Preoperative glenoid BMD (CT numbers in Hounsfield unit) was measured in 3D using a reliable semi-automated quantitative method, in the following six contiguous volumes of interest (VOI): cortical, subchondral cortical plate (SC), subchondral trabecular, and three successive adjacent layers of trabecular bone. Univariate Cox regression was used to estimate the impact of preoperative glenoid BMD on aseptic glenoid implant loosening. We further compared 26 aseptic glenoid loosening patients with 56 matched control patients.Results: Glenoid implant survival rates were 89% (95% confidence interval CI, 81%-96%) and 57% (41%-74%) at 5 and 10 years, respectively. Hazard ratios for the different glenoid VOIs ranged between 0.998 and 1.004 (95% CI [0.996, 1.007], p≥0.121). Only the SC VOI showed significantly lower CTn in the loosening group (622±104 HU) compared with the control group (658±88 HU) (p=0.048), though with a medium effect size (d=0.42). There were no significant differences in preoperative glenoid BMD in any other VOI between patients from the loosening and control groups.Conclusions: Although the preoperative glenoid BMD was statistically significantly lower in the SC region of patients with aseptic glenoid implant loosening compared with controls, this single-VOI difference was only moderate. We are thus unable to prove that lower preoperative glenoid BMD is clearly associated with and a risk factor for aseptic glenoid implant loosening in aTSA. However, due to its proven biomechanical role in glenoid implant survival, we recommend extending this study to larger CT datasets to further assess and better understand the real impact of preoperative glenoid BMD on glenoid implant loosening/survival and aTSA outcome overall.Trial registration: Retrospectively registered
A “Full Spectrum-Domain-Time” Coalbed Gas Utilization Model and Its Application in Mining area
Authors: Linghu Jianshe , Chen Jinhua , Zhou Jianbin , Jiang Wangang 
Published: September 2020

Abstract
Background: As an important energy source, coalbed gas (CBG) has been widely used. However, the allocation system of CBG resources is not perfect. During the utilization process, a large amount of CBG is discharged into the air, causing environmental pollutionMethods: In this study, we proposed a “full spectrum-domain-time” CBG utilization model, including full spectrum CBG utilization technology and full domain CBG supply, In addition, based on time series algorithms, real-time prediction of the demand for CBG, grasp the characteristics of time changes in demand, and scientifically allocate resources, that is, “full-time” regulation. Taking Yangquan Coal Group, Shanxi Province, China, as a case study, introduced the application of the “full spectrum-domain-time” utilization model in the enterprise, and at last assessed the achievement of the model application. Results and Conclusions: The time series algorithm can be used to predict CBG demand in different regions of the mining area. Driven by this model, both the total CBG and low-concentration CBG utilizations in the Yangquan Coal Group increase year after year, making it promising to reach 77.15% of CBG utilization rate and indicating that application of the model has made great accomplishment.
Schlafen family member 5 (SLFN5) regulates LAT1-mediated mTOR activation in castration-resistant prostate cancer
Authors: Martinez Rafael , Salji Mark , Rushworth Linda , Ntala Chara , Blanco Giovanny Rodriguez , Hedley Ann , Clark William , Peixoto Paul , Hervouet Eric , Renaude Elodie , Kung Sonia , Galbraith Laura C. A. , Nixon Colin , Lilla Sergio , Mackay Gillian , Fazli Ladan , Sumpton David , Gleave Martin , Zanivan Sara , Blomme Arnaud , Leung Hing 
Published: September 2020

Abstract
Androgen-deprivation therapy (ADT) is the standard of care for the treatment of non-resectable prostate cancer (PCa). Despite high treatment efficiency, most patients ultimately develop lethal castration-resistant prostate cancer (CRPC). In this study, we perform a comparative proteomic analysis of three in vivo, androgen receptor (AR)–driven, orthograft models of CRPC. Differential proteomic analysis reveals that distinct molecular mechanisms, including amino acid (AA) and fatty acid (FA) metabolism, are involved in the response to ADT between the different models. Despite this heterogeneity, we identify SLFN5 as an AR-regulated biomarker in CRPC. SLFN5 expression is high in CRPC tumours and correlates with poor patient outcome. In vivo, SLFN5 depletion strongly impairs tumour growth in castrated condition. Mechanistically, SLFN5 interacts with ATF4 and regulates the expression of LAT1, an essential AA transporter. Consequently, SLFN5 depletion in CRPC cells decreases intracellular levels of essential AA and impairs mTORC1 signalling in a LAT1-dependent manner.
Relationship Between Tumor Mutational Burden and Maximum Standardized Uptake Value in PET (Positron Emission Tomography) Scan in Cancer Patients
Authors: Jahromi Amin Haghighat , Barkauskas Donald A , Zabel Matthew , Goodman Aaron M. , Frampton Garret , Nikanjam Mina , Hoh Carl K , Kurzrock Razelle 
Published: September 2020

Abstract
Purpose: Deriving links between imaging and genomic markers is an evolving field. 18F-FDG PET/CT (18F-fluorodeoxyglucose Positron Emission Tomography- Computed Tomography) is commonly used for cancer imaging, with maximum standardized uptake value (SUVmax) as the main quantitative parameter. Tumor mutational burden (TMB), the quantitative variable obtained using next-generation sequencing on a tissue biopsy sample, is a putative immunotherapy response predictor. We report the relationship between TMB and SUVmax, linking these two important parameters. Methods: In this pilot study, we analyzed 1923 patients with diverse cancers and available TMB values. Overall, 273 patients met our eligibility criteria in that they had no systemic treatment prior to imaging/biopsy, and also had 18F-FDG PET/CT within six months prior to the tissue biopsy, to ensure acceptable temporal correlation between imaging and genomic evaluation. Results: We found a linear correlation between TMB and SUVmax (p<0.001). In the multivariate analysis, only TMB independently correlated with SUVmax whereas age, gender and tumor histology did not. Conclusion: Our observations link SUVmax in readily available, routinely used, and non-invasive 18F-FDG PET/CT imaging to the TMB, which requires a tissue biopsy and time to process. Since higher TMB has been implicated as a prognostic biomarker for better outcomes after immunotherapy, further investigation will be needed to determine if SUVmax can stratify patient response to immunotherapy.
Interleukin-34 is associated with hepatocellular carcinoma in chronic hepatitis B patients
Authors: Liu Kehui , Ding Yezhou , Wang Yun , Zhao Qingqing , Yan Lei , Xie Jingdong , Liu Yunye , Xie Qing , Cai Wei , Bao Shisan , Wang Hui 
Published: September 2020

Abstract
Backgrounds: IL‑34 is involved in a number of auto-immunities and cancers. We explored the relationship between serum/hepatic IL‑34 and hepatitis B virus (HBV) related hepatocellular carcinoma (HBV‑HCC) patients.Methods: Serum was obtained from the HBV patients or healthy control with written consents. Liver tissue was obtained from liver biopsy in CHB, HBV related cirrhosis patients or curative resection in HBV‑HCC patients. Serum IL‑34 and MCSF were measured, using ELISA. HepaticIL‑34, MCSF and CD68 were determined, using immunohistochemistry.Results: Serum IL‑34 was 1.7, 1.6 or 1.7 fold higher in HBV‑HCC than that of the other three groups (CHB, HBV related cirrhosis, and healthy control). Serum IL‑34 was significantly reduced after trans‑hepatic arterial chemoembolization (TACE) in HBV‑HCC patients. There was significant correlation between the incidence of HBV‑HCC and IL‑34 (rs=0.160, p<0.05) as well as AFP (rs=0.442, p<0.01). Furthermore, intra-hepatic IL‑34 was higher in HBV‑HCC than that of the other three groups. Intra-hepatic IL‑34 was associated with high HBV‑DNA, HBeAg-, low tumor differentiation and small tumor size of HBV‑HCC patients. Intra-hepaticCD68+ TAMs were increased 1.6 or 1.3 fold in HBV‑HCC compared to that from CHB or HBV-cirrhosis. Intra-hepatic CD68+ TAMs were associated with high HBV‑DNA, high tumor differentiation, big tumor size, abnormal AFP and more tumor number.Conclusions: IL‑34, correlated with HBV‑HCC and IL‑34, may be used as a therapeutic target in precise medicine for management of HBV‑HCC.
A Pragmatic Trial of Active Versus Passive Teaching for Clinically Integrating Evidence Based Medicine Teaching in an Undergraduate Medical School.
Authors: Kumaravel Bharathy , Stewart Claire , Ilic Dragan 
Published: September 2020

Abstract
Background Clinically integrated Evidence Based Medicine (EBM) teaching promotes higher order application of knowledge, skills, and behaviours. There is, however, limited evidence on the most efficient model for clinically integrating EBM teaching. The aim of this study was to test the feasibility of integrating EBM teaching into clinical placements in an undergraduate medical school and compare the effectiveness of two different methods of EBM teaching - active teaching and passive teaching. Methods Active teaching involved blended learning methods and facilitated small group discussions. Passive teaching involved self-directed small group discussions and a remote live telecast taught session. Students’ EBM competencies were assessed using the Assessing Competency in EBM (ACE tool) and Educational Prescriptions (EP) and in summative final professional written and clinical examinations.Results Education was delivered to 65 students, of whom 45 received active teaching, while 20 received passive teaching. Students receiving active teaching performed better in EPs (MD=-2.28, -4.31, -0.26). There was no significant difference in performances in the ACE tool (MD=-1.02, -2.20, 0.16); the written final professional exams (MD=-0.11, -0.65, 0.44) and the EBM OSCE stations (MD=-0.81, -2.38, 0.74). Conclusions It was feasible to integrate EBM teaching into clinical placements in an undergraduate medical school. Both active and passive methods were effective in delivering EBM teaching. While students in the active teaching model scored higher in EPs; there was no significant difference in performances in the ACE tool or the summative assessments. Scaffolding student learning or a spiral approach to EBM teaching model provides a great example of continually shifting the zone of proximal development.
Depression, Anxiety and Stress Symptomatology among Swedish University Students Before and During the COVID-19 Pandemic: A Cohort Study.
Authors: Johansson Fred , Côté Pierre , Hogg-Johnson Sheilah , Rudman Ann , Holm Lena W. , Grotle Margreth , Jensen Irene , Sundberg Tobias , Edlund Klara , Skillgate Eva 
Published: September 2020

Abstract
Background. The COVID-19 pandemic has had a profound effect on societies, economies, and daily life of citizens worldwide. This has raised important concerns about the mental health of different populations. We aimed to determine if symptom levels of depression, anxiety, and stress were different during the COVID-19 outbreak compared to before, with the Depression, Anxiety and Stress Scale as main outcome. We also aimed to determine whether pre-pandemic loneliness, poor sleep quality and mental health problems were associated with worse trajectories of mental health. Methods. We conducted a cohort study with 1658 Swedish university students answering questionnaires before the pandemic and a 81 % response-rate to follow-ups during the pandemic. Generalized Estimating Equations were used to estimate mean levels of symptoms before and during the pandemic, and to estimate effect modification by levels of loneliness, sleep quality and pre-existing mental health problems. Results. We found small differences in symptoms. Mean depression increased by 0.23/21 (95% CI:0.03 to 0.43), mean anxiety decreased by -0.06/21 (95% CI: -0.21 to 0.09) and mean stress decreased by - 0.34/21 (95% CI: -0.56 to -0.12). Loneliness, poor sleep quality and pre-existing mental health problems minimally influenced trajectories. Conclusions. Contrary to widely held concerns, we found minimal changes in mental health among Swedish university students during the first months of the COVID-19 pandemic.
Novel method to achieve crystallinity of calcite by Bacillus subtilis in&nbsp;coupled and non-coupled calcium-carbon sources
Authors: Ferral-Pérez Héctor , Galicia-García Mónica , Alvarado-Tenorio Bonifacio , Izaguirre-Pompa Aldo , Aguirre-Ramírez Marisela 
Published: September 2020

Abstract
Bacteria mineralization is a promising biotechnological approach to apply in biomaterials development. In this investigation, we demonstrate that Bacillus subtilis 168 induces and influences CaCO3 composites precipitation. Crystals were formed in calcium-carbon non-coupled (glycerol + CaCl2, GLY; or glucose + CaCl2, GLC) and coupled (calcium lactate, LAC; or calcium acetate, ACE) agar-sources, only maintaining the same Ca2+ concentration. The mineralized colonies showed variations in morphology, size, and crystallinity form properties. The crystals presented spherulitic growth in all conditions, and botryoidal shapes in GLC one. Birefringence and diffraction patterns confirmed that all biogenic carbonate crystals (BCC) were organized as calcite. The CaCO3 in BCC was organized as calcite, amorphous calcium carbon (ACC) and organic matter (OM) of biofilm; all of them with relative abundance related to bacteria growth condition. BCC-GLY presented greatest OM composition, while BCC-ACE highest CaCO3 content. Nucleation mechanism and OM content impacted in BCC crystallinity.
Cardiac arrest after small doses ropivacaine: Local Anesthetic Systemic Toxicity in the course of continuous femoral nerve blockade
Authors: Gola Wojciech , Bialka Szymon , Zajac Marek , Smereka Jacek , Szarpak Lukasz 
Published: September 2020

Abstract
Background: The paper presents a case report of an episode of local anesthetic systemic toxicity (LAST) with cardiac arrest after continuous femoral nerve blockade in a 74-year-old female patient after elective total knee replacement surgery. Case presentation: A 74-year-old patient burdened with hypertension, osteoarthritis, underwent elective total knee replacement surgery (TKR). After surgery, a continuous femoral nerve blockade was performed and an infusion of a local anesthetics (LA) was started using an elastomeric pump. Five hours after surgery, the patient had an episode of generalized seizures followed by cardiac arrest. After resuscitation, spontaneous circulation was restored and the patient was transferred to the Intensive Care Unit. 20% lipid emulsion was used in the treatment. On day 2 of the ICU stay, the patient was fully cardiovascularly and respiratorily stable without neurological deficits and was discharged to the orthopedic department to continue treatment. Conclusion: Systemic toxicity of LA is a serious and potentially fatal complication of the use of LA in clinical practice. The incidence of LAST is underestimated, although in recent years there has been a significant decrease in the incidence of this serious complication. It should be noted that in nearly 40% of patients, LAST deviates from the classic and typical course and may have an atypical manifestation, and the first symptoms may appear with a long delay, especially when continuous blockades are used. Therefore, proper supervision of the patient and the developed procedure in the event of LAST is undoubtedly important here. If the first serious symptoms of LAST appear, current guidelines recommend early application of 20% lipid emulsion.
Relationship between anxiety and abnormal behavior in children with asthma in Lanzhou, China
Authors: Shi Daiyu , Li Guirong , Li YuanLin , Zhang RongFang , Na Feiyang , Gao Wenlong 
Published: September 2020

Abstract
Background: Asthma can increase the risk of anxiety and abnormal behavior among children but the correlation between anxiety and behavioral abnormalities in children with asthma was unclear. Methods: The Self-Rating Anxiety Scale and the Rutter Children’s Behavior Questionnaire were used to conduct surveys with 337 children aged 6 to 14 years who were diagnosed in the asthma clinic of Gansu Provincial Maternity and Child Care Hospital in Lanzhou, China from January to December 2019. SPSS 22.0 software was used to perform multivariate logistic regression and factor analysis on the items of the anxiety scale to extract different anxiety manifestations. Results: The abnormal behavior rate was 37.1% among the 337 investigated children with asthma. A total of 3 factors were extracted by factor analysis on the 20 items of the anxiety scale, namely mental, sensory, and hand-and-foot manifestations. The 3 factors were divided into 3 groups using tertiles (Q1~Q3). After controlling for sex, age, wheezing history, marital status of parents, caregiver awareness, and caregiver’s home care situation, compared with Q1, the multivariate logistic regression model showed that Q3 had a statistically significant relationship with abnormal behavior, regardless of mental or hand-and-foot manifestation. No connection between Q2 and behavior abnormalities was found. For sensory manifestations, neither Q3 nor Q2 was significantly related to abnormal behavior. Conclusions: Abnormal behavior was related to only severe anxiety among children with asthma. Therefore, psychological intervention should be carried out as early as possible in the treatment of children with asthma to prevent and correct abnormal behavior.
Complications of COVID-19 , a case with both neurological and dermatological complications.
Authors: davoodian parivash , korani setayesh sotoudehnia , roudkoli ali rezazadeh , ouspid elham 
Published: September 2020

Abstract
Recently, different complications and clinical manifestations of COVID-19 have been reported such as neurological or dermatological complications, We present a confirmed COVID-19 case of diplopia and ophthalmoplegia presenting skin lesions at the same time .
Association Between Inhaled Corticosteroid Use and the Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Nationwide Population-based Study in South Korea
Authors: Lee Sang Chul , Son Kang Ju , Han Chang Hoon , Jung Ji Ye , Park Seon Cheol 
Published: September 2020

Abstract
Background

Inhaled corticosteroid (ICS) use may increase the risk of respiratory infection, but its influence on the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is not known. This study aimed to investigate the association between ICS use and the risk of SARS-CoV-2 infection among the patients with chronic respiratory diseases.
Methods

The Ministry of Health and Welfare and Health Insurance Review and Assessment Service in Korea provided nationwide data of 44,968 individuals with chronic respiratory diseases tested for SARS-CoV-2 until May 15. The risks of SARS-CoV-2 infection were retrospectively analysed according to the prescription, type, and dose of ICS taken one year before SARS-CoV-2 test.
Results

Among 44,968 individuals tested, 931 (2.1%) were positive for SARS-CoV-2. A total of 7,019 patients (15.6%) were prescribed ICS one year prior to being tested for SARS-CoV-2. Low, medium, and high doses of ICS were prescribed in 7.5%, 1.6%, and 6.5% of total cases, respectively. Among the types of ICS, budesonide, fluticasone, beclomethasone, and ciclesonide were prescribed in 3.7%, 8.9%, 2.3%, and 0.6% of total cases, respectively. The multivariate analysis showed no significant increase in infection with ICS use (OR, 0.84; 95% CI, 0.66–1.03). Moreover, there were no associations between the risk of infection, and doses or types of ICS prescribed.
Conclusion

Prior ICS use did not increase the risk of SARS-CoV-2 infection. Moreover, different doses or types of ICS did not affect the risk. This study supports the current guidelines to manage patients taking ICS during the SARS-CoV-2 pandemic.
Efficiency of the Damage Control Orthopedic Strategy in the Management of Military Ballistic Limb Trauma.
Authors: Amri Khalil , Tounsi Ahmed , Oueslati Achraf , Salah Mouhamed Ben , Dhahri Rim , Chourabi Chadia , Nouisri Lotfi 
Published: September 2020

Abstract
Background: In conflicting areas, orthopaedic surgeons adopted this concept of damage control orthopaedic (DCO) to face limb fracture due to ballistic trauma because of the gravity of the hurts, the limitation of equipment, and precarious conditions of asepsis. They use external fixation as an initial treatment at the nearest health centre. They delay the definitive treatment to be realized in better conditions. Our study aims to assess the outcome of the damage control orthopaedic (DCO) strategy in military ballistic limb trauma according to the experience of the Military Hospital of Tunisia.Materials and methods: This study is a retrospective study on patients who were hospitalized for a limb ballistic fracture. It includes military patients treated urgently with primary external fixation at the nearest health centre. We adapted the Gustilo classification to describe wound opening, the Winquist and Hansen classification to define fracture comminution and the grading system for bone loss to evaluate bone loss. Then, all victims were evacuated secondary to the military hospital to receive the definitive treatments. The conversion to internal osteosynthesis had taken place according to some criteria. They were the absence of local sepsis, a haemoglobin level (> 10 g/dl), a serum protein level (> 50 g/l) and negative or falling CRP kinetics. We studied the delay of conversion from external fixation to internal osteosynthesis, bone healing time and complications.Result: Our study included 32 patients, all men, with a mean age of 31 years. The average follow-up was 33.2 months. Eighty-eight percent of trauma concerned the lower limb. The average delay for conversion from external fixation to internal osteosynthesis was 7.8 days. Bone union was achieved in 26 cases, with an average delay of 4.23 months. The observed general complications were anaemia, pulmonary embolism and rhabdomyolysis. Local complications were essentially sepsis on osteosynthesis material and pseudarthrosis. These complications were significantly associated with a type III Gustilo skin opening, a type III and IV Winquist fracture comminution, a type II and III Grading system for bone loss, and a delay in conversion from external fixation to internal osteosynthesis.Conclusion: DCO is a global strategy that involves all measures participating in the acceleration of wound healing and fighting against infection. These measures shorten the delay of conversion from external fixation into internal osteosynthesis, which constitutes a key parameter in the management of limb fracture due to ballistic trauma.