bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clínica da atividade e oficina de fotos: eletricistas em foco
Authors: Pacheco Alves Emanuelle de Aguiar , Da Silva Claudia Osorio 
Published: August 2020

O artigo apresenta uma experiência de análise das atividades do trabalhador de energia elétrica em uma cidade, com base no dispositivo de Oficina de fotos e tendo como referência teórica a Clínica da Atividade. O foco do estudo está na análise da atividade dos trabalhadores que exercem o ofício de eletricistas no município de Maricá, no estado do Rio de Janeiro. O contexto estudado é de terceirização, onde a precarização das relações de trabalho é um agravante. Devido a isso, torna-se imprescindível estudar a organização do trabalho e o enriquecimento de seu coletivo profissional. A Oficina de fotos foi escolhida como dispositivo de pesquisa e intervenção a fim de utilizar as imagens como disparadores da co-análise do trabalho, fazendo emergir uma realidade coletiva, presente em todas as atividades de trabalho. Visa, ainda, propiciar que outras relações mais potentes possam ser (re) criadas por meio da ampliação de suas possibilidades de ação.
Palavras-chave: Psicologia do trabalho; Clínica da atividade; Oficina de fotos; Eletricistas.
O psicólogo no NASF: potencialidades e desafios de um profissional de referência
Authors: Matos Ferreira Furtado Maria Edilânia , Carvalho Liliane Brandão 
Published: August 2020

Configura objeto de investigação deste trabalho a compreensão do lugar do psicólogo no Núcleo de Apoio à Saúde
da Família (NASF). Para tanto, realizamos uma revisão bibliográfica para contextualizar o surgimento do Sistema
Único de Saúde e a criação do NASF, enquanto política oriunda de mudanças implementadas no campo da saúde
pública brasileira. O estudo contempla ainda uma revisão dos desafios impostos ao profissional de psicologia para
se inserir nesse campo. São marcos paradigmáticos dessa inserção as Reformas Sanitária e Psiquiátrica brasileiras
que possibilitaram ao psicólogo compor equipes multidisciplinares. Inserção essa ampliada com a criação do NASF
que inclui o psicólogo entre os possíveis profissionais de sua equipe, ampliando assim os desafios em sua práxis. Os
achados revelam desafios impostos à atuação do psicólogo no campo da saúde pública, que por sua vez, concebe a
esse profissional na equipe NASF um lugar de referência, especialmente, nos cuidados em saúde mental.
Palavras-chave: SUS; Atenção primária à saúde; NASF; Prática do psicólogo.
A internação compulsória e suas variáveis: reflexões éticas e socioculturais no tratamento e reinserção do paciente na sociedade
Authors: Reguera Ruiz Viviana Rosa , Marques Heitor Romero 
Published: August 2020

A drogadição e suas consequências, após muitas tentativas de enfrentamento, ainda remetem um desafio quanto
ao melhor tipo de tratamento a ser destinado aos dependentes químicos. A questão emerge perante a sociedade
e não é possível solucionar somente com medidas paliativas. Este artigo pretende analisar as questões éticas e
socioculturais interpostas na utilização da internação compulsória no tratamento da dependência química. Para
tanto, o recurso utilizado foi de revisão bibliográfica para enfatizar a medida de intervenção obrigatória na saúde
do drogodependente, reformulada pela Lei n. 10.216/01, por ser realizada sem a submissão do paciente. O artigo
faz um breve apanhado histórico acerca das legislações que regulamentam as drogas desde o proibicionismo da
segunda metade do século XX até a atual Lei n. 11.343/06. O artigo discute as responsabilidades de cada ente social,
bem como a do próprio usuário de drogas frente a sua capacidade de decisão. Ademais, evidencia a necessidade
da construção de estruturas adequadas para tratar da drogadição, elemento fundamental para a reinserção social.
Palavras-chave: Internação compulsória; Dependência química; Drogas; Tratamento; Sociedade.
Percursos e percalços na investigação da emoção na Psicologia de Vigotski
Authors: Luz Heriel , Martins de Souza Ana Lucia , Dos Santos Lívia Gomes 
Published: August 2020

Neste artigo serão apresentados e discutidos aspectos do caminho trilhado pelo psicólogo bielorrusso Vigotski
em seu interesse por produzir uma Psicologia Histórico-Cultural, onde a emoção fosse elevada da posição de
mera coadjuvante para a de protagonista na dinâmica subjetiva. Seu interesse repousou na busca de respostas às
controversas e antitéticas teorias que hora assumiram a emoção como substância imanente e hora como substrato
biológico em vias de desaparecimento em sintonia com o darwinismo, mas sem proporem caminhos de superação
para essa contradição. Pautado nos fundamentos do Materialismo Histórico e do Materialismo Dialético, o autor
propôs-se a investigar a emoção pela síntese histórica, mostrando que o desenvolvimento das funções psicológicas
superiores, dentre elas a emoção, tema desse artigo, está condicionado a sua ação mediadora da vida psíquica. As
contribuições de seus estudos produziram impactos que repercutem até os dias atuais nas diferentes áreas científicas
que se dedicam à investigação da emoção.
Palavras-chave: Emoção; Método histórico; Vigotski.
ANALISIS PROFIL KEMANDIRIAN BELAJAR MAHASISWA DI PERGURUAN TINGGI
Authors: Arifin Maksum  , Ika Lestari  
Published: August 2020

ABSTRAK

Mahasiswa memiliki pola pembelajaran yang seyogyanya berbeda dengan siswa di level sekolah. Untuk itu, kemandirian belajar perlu tumbuh dalam diri mahasiswa agar dapat mengembangkan ide-ide kreatif tanpa bantuan dosen secara penuh. Kemandirian belajar sangat menentukan media maupun model pembelajaran yang dapat diterapkan. Untuk itu, perlu dilakukan analisis profil kemandirian belajar mahasiswa di perguruan tinggi sebagai landasan dalam mempertimbangkan penggunaan model atau media pembelajaran tertentu. Teknik pengumpulan data yang digunakan yaitu kuesioner. Penelitian dilaksanakan di Kampus E PGSD FIP UNJ selama tahun 2019. Teknik analisis data menggunakan statistik deskriptif sederhana dan analisis kualitatif. Hasil penelitian berupa profil kemandirian belajar yang dimiliki oleh mahasiswa PGSD FIP UNJ angkatan tahun 2017. Rekomendasi untuk penelitian masa depan diperlukan model pembelajaran yang melibatkan unsur teknologi di dalamnya sehingga dapat meningkatkan kemandirian belajar mahasiswa melalui pola pembelajaran yang mengaktifkan mahasiswa di perguruan tinggi.

Kata-kata kunci: kemandirian belajar, mahasiswa, pembelajaran

ABSTRACT

Students at the university have learning patterns that should be different from students at the school level. For this reason, learning independence needs to grow within students at the university in order to develop creative ideas without the full assistance of lecturers. Learning independence determines the media and instructional models that can be applied. For this reason, it is necessary to analyze the profile of students' learning independence in higher education as a basis for considering the use of certain instructional models or media. Data collection techniques used were questionnaires. The study was conducted at Campus E PGSD FIP UNJ during 2019. Data analysis techniques used simple descriptive statistics and qualitative analysis. The results of the study are in the form of learning independence that is owned by PGSD FIP UNJ students in 2017. Recommendations for future research require learning models that involve elements of technology in order to increase student learning independence through learning patterns that enable students in higher education.
Key words: learning independence, students, learning
Prognostic significance of NDRG2 combined with EGFR-sensitizing mutations in lung adenocarcinoma
Authors: Yang Bo , Ji Linlin , Feng Yiling , Li Xiao-Ping , Zhou Hong-Gang , Jiang Tao , Xiao Ting , Li Xiao-He , Zhang Liang , Xu Hongliang , Wang Guang-Shun , Zhang Wei-Dong 
Published: August 2020

Abstract
Background: N-myc downstream-regulated gene 2 (NDRG2) plays a substantial role in lung adenocarcinoma (LUAD). Epidermal growth factor receptor (EGFR)-sensitizing mutation could significantly improve prognosis in patients with LUAD. Here, we aimed to elucidate the prognostic value of NDRG2 combined with EGFR-sensitizing mutations in patients with LUAD. Methods: Lung parenchyma specimens obtained during surgery or CT-guide percutaneous lung puncture biopsy for the NDRG2 protein and EGFR genomic testing were obtained. Associations between NDRG2/EGFR and clinicopathological characteristics of patients with LUAD were extracted from the Tianjin First Central Hospital in China between June 2013 and June 2014. Results: The expression of NDRG2 was significantly decreased in patients with LUAD. Expressions of NDRG2 and EGFR-sensitizing mutations showed positive correlations with survival. Expression of NDRG2 and EGFR-sensitizing mutations were associated with the longer overall survival (OS), disease-free survival (DFS) and progression-free survival (PFS). Advanced stages were significantly associated with low expression of NDRG2. In multivariate analysis, compared with other patients, NDRG2 (+)/EGFR (+) was independently associated with prolonged OS and PFS. Conclusion: NDRG2 combined with EGFR-sensitizing mutations might be valuable markers to evaluate the prognosis of LUAD patients.
‘I’ve got to be independent’: Views of older people on recovery following road traffic injury in New South Wales, Australia
Authors: Brown Katherine , Cameron Ian D , Keay Lisa , Nguyen Ha , Dillon Lisa , Jagnoor Jagnoor , Ivers Rebecca 
Published: August 2020

Abstract
Background: Mild to moderate road traffic injury (RTI) in people of working age is associated with limited recovery. Less is known about RTI recovery in older age. This study explored the perspectives and factors associated with recovery and health-related quality of life following mild to moderate RTI in older age in New South Wales, Australia. Methods: A qualitative study using content analysis was undertaken. Participants aged 65 or more years were purposively selected from a larger inception cohort study of health outcomes following mild to moderate RTI conducted in New South Wales, Australia. Semi-structured interviews were undertaken at approximately 12 or 24 months post-injury. Content analysis was used to code and analyse the data, with methodological rigour obtained by double-coding and discussing findings to reach consensus. Results were reported using the consolidated criteria for reporting qualitative research (COREQ). Results: Nineteen participants were invited to participate in the study of which 12 completed interviews. Data saturation was reached at the twelfth interview. Recovery experiences were diverse. Five main themes were identified: recovery is regaining independence; injury and disability in older age; the burden of non-obvious disability; the importance of support; and positive personal approaches. Key facilitators of recovery were: regaining independence; support from family and friends; and positive personal approaches. Key barriers were: threats to independence; passive coping behaviours; non-obvious disabilities (chronic pain, psychological impacts); and reluctance to raise ongoing issues with General Practitioners. Threats to independence, especially not driving and self-care, appeared to have a more profound effect on recovery than physical functioning. Conclusion: Older people view injury as a threat to independent functioning. This is somewhat different to what younger people report. Regaining independence is key to older people’s recovery and health-related quality of life following RTI, and should be a key consideration for health professionals, services and supports working with this unique cohort. Greater efforts to help older people regain their independence following RTI are needed and can be facilitated by health professionals and appropriate service provision. Trial registration: Australia New Zealand clinical trial registry identification number ACTRN12613000889752.
Co-infection with trichomonas vaginalis increases the risk of cervical intraepithelial neoplasia grade 2-3 among HPV16 positive female: a large population-based study.
Authors: Yang Mei , Li Lin , Jiang Chunfan , Qin Xiaomin , Zhou Min , Mao Xiaogang , Xing Hui 
Published: August 2020

Abstract
Background: Evidence suggested that vaginal microbiome played a functional role in the progression of cervical lesions in female infected by HPV. This study aimed at evaluating the influence of common vaginal infection on the carcinogenicity of high risk HPV (hr-HPV). Methods: From January 15, 2017 to December 31, 2017, 310,545 female aged at least 30 years old had been recruited for cervical cancer screening from 9 clinical research centers in Central China. All the recruited participants received hr-HPV genotyping for cervical cancer screening and vaginal microenvironment test by a high vaginal swab. Colposcopy-directed biopsy was recommended for female who were infected with HPV 16 and HPV 18, and other positive hr-HPV types through test had undertaken triage using liquid-based cytology, cases with the results ≥ ASCUS among them were referred to colposcopy directly, and cervical tissues were taken for pathology examination to make clear the presence or absence of other cervical lesions.Results: Among 310,545 female, 6,067 (1.95%) were tested with positive HPV 16 and HPV 18, 18,297 (5.89%) were tested with other positive hr-HPV genotypes, cervical intraepithelial neoplasia (CIN) 1, CIN 2, CIN 3 and invasive cervical cancer (ICC) were detected in 861 cases, 377 cases, 423 cases, and 77 cases, respectively. Candida albicans and Gardnerella were not associated with the detection of cervical lesions. Positive trichomonas vaginitis (TV) was correlated with hr-HPV infection (p<0.0001). Co-infection with TV increased the risk of CIN 1 among female infected with hr-HPV (OR 1.18, 95% CI: 1.42-2.31). Co-infection with TV increased the risk of CIN 2-3 among female infected with HPV 16 (OR 1.71, 95% CI: 1.16-2.53).Conclusions: Co-infection of TV and HPV 16 is a significant factor for the detection of cervical lesions.
Does Pregabalin change serum levels of iNOS and NO in diabetic patients with neuropathic pain?A quasi-experimental study
Authors: Memari Moosareza , Sadatamini Mirsaber , Khazaei-Poul Yalda , Joharchi Khojasteh 
Published: August 2020

Abstract
Background: Pregabalin (PGB) has been approved
for the treatment of diabetic peripheral neuropathic pain (DPNP),
but the mechanism of the PGB effect in this situation is not
precisely known. Would it be via the reduction of inducible
Nitric‏ ‏Oxide ‎Synthase (iNOS) and thus the
decrease of Nitric Oxide (NO) in type 2 diabetic patients? The
current clinical trial was conducted to answer this question.
Methods: Twenty Seven diabetic patients with
DPNP>4, assessed by Visual Analogue Scale (VAS), were enrolled
in this study. They received placebo/Bd for ten days as a washout
period, then a starting dose of 75mg/Bd PGB for one week and
150mg/Bd for the next seven weeks. We took a fasting blood sample
at baseline, before starting the treatment (BT) with PBG, then one
month after the treatment (OMT), and also at the end of two months
(TMT). The iNOS and NO serum levels were measured using the ELISA
kit and the Griess method, respectively.
Results: Significant time-dependent reduction
of iNOS of serum and DPNP intensities observed (P<0.05).
However, the serum levels of NO reduced significantly in OMT
compared to BT (P<0.05), but no significant differences were
seen between OMT and TMT (P>0.05).
Conclusions: Our study revealed a direct
correlation between serum levels of iNOS and NO with the treatment
of DPNP by PGB, thus introducing a possible mechanism for
pain-relieving properties of PGB.
Trial registration: This study was approved by
the ethics committee of our University of Medical ‎Sciences,
(ethical code: IR.SBMU.MSP.REC.1395.41) and registered in our
‎Registry of Clinical Trials (at 14/03/2016) and approved in
19/07/2017, the registration number is: (IRCT2017012932277N1). The
study was conducted in the Diabetes Clinic of a teaching ‎Hospital
on 22/07/2017 till 18/03/2018.‎ We have explained the study
objectives and protocols to the subjects and obtained written
informed ‎consent before they participated in the study.‎
RoadMApp: A feasibility study for a smart travel application to improve maternal health delivery in a low resource setting in Zimbabwe
Authors: Nyati-Jokomo Zibusiso , Dabengwa Israel Mbekezeli , Makacha Liberty , Nyapwere Newton , Dube Yolisa Prudence , Chikoko Laurine , Vidler Marianne , Makanga Prestige Tatenda 
Published: August 2020

Abstract
Background: Travel time and healthcare financing are critical determinants of the provision of quality maternal health care in low resource settings. Despite the availability of pregnancy-related mHealth and smart travel applications, there is a lack of evidence on their usage to travel to health facilities for routine antenatal care and emergencies. There is a shortage of information about the feasibility of using a custom-made mobile technology that integrates smart travel and mHealth. This paper explores the feasibility of implementing a custom-made geographically enabled mobile technology-based tool (RoadMApp) to counter the adverse effects of long travel times for maternal care in Kwekwe District, Zimbabwe. Methods: We frame the paper using the first two steps (listen & plan) of the Spiral Technology Action Research (STAR model).The paper uses an exploratory case study design and Participatory Learning Approaches (PLA) with stakeholders (community members) and in-depth interviews with key informants (health care service providers, pregnant women, transport operators). 193 participants took part in the study. We conducted focus group discussions with pregnant women, women of childbearing age, men (household heads), and elderly women. The discussion questions centered on travel time, availability of transport, cellular network coverage, and perceptions of the RoadMApp application. Data were analysed thematically using Nvivo Pro 12. Results: Most parts of rural Kwekwe are far from health facilities and have an inefficient road and telecommunications network. Hence, it is hard to predict if RoadMApp will integrate into the lives of the community - especially those in rural areas. Since these issues are pillars of the design of the RoadMApp mHealth, the implementation will probably be a challenge. Conclusion: Communities are keen to embrace the RoadMApp application. However, the feasibility of implementing RoadMApp in Kwekwe District will be a challenge because of maternal health care barriers such as poor road network, poor phone network, and the high cost of transport. There is a need to investigate the social determinants of access to maternity services to inform RoadMApp implementation.
HKDC1 promotes the tumorigenesis and glycolysis in lung adenocarcinoma via regulating AMPK/mTOR signaling pathway
Authors: Wang Xinyu , Shi Bowen , Zhao Yue , Lu Qijue , Fei Xiang , Lu Chaojing , Li Chunguang , Chen Hezhong 
Published: August 2020

Abstract
Background: Hexokinase domain component 1 (HKDC1) plays an oncogenic role in certain types of cancer, such as lymphoma, liver cancer, and breast cancer. Previous bioinformatics study revealed that HKDC1 was significantly upregulated in lung adenocarcinoma (LUAD). However, its biological functions and potential mechanism in LUAD have not been studied.

Methods: We performed bioinformatics analysis, quantitative real-time polymerase chain reaction (qRT-PCR), western blotting, immunohistochemistry, and a series of functional assays in vitro and in vivo to investigate the roles of HKDC1 in LUAD.

Results: We discovered that HKDC1 was highly expressed in LUAD tissues and cell lines, and the positive expression of HKDC1 was correlated with aberrant clinicopathological characteristics in LUAD patients. Furthermore, HKDC1 could serve as a prognostic predictor for LUAD patients. Overexpression of HKDC1 promoted proliferation, migration, invasion, glycolysis, EMT and tumorigenicity, whereas knockdown of HKDC1 produced the opposite functional effects. Mechanistically, HKDC1 could regulate the AMPK/mTOR signaling pathway to perform its biological function.

Conclusions: Our findings suggest that HKDC1 plays an oncogenic role in LUAD. Targeting this gene may provide a promising therapeutic target to delay LUAD progression.
Strengthening Retina Eye Care Services in Nepal: Retina Eye Care of Nepal project
Authors: Shrestha Arjun , Shrestha Chunu , Karki Pratap , Gurung Hara Maya , Naito Takeshi 
Published: August 2020

Abstract
Background: Retinal diseases are very difficult to treat. So, early diagnoses and preventions are very important. But, few eye doctors can treat patients with retinal diseases in Nepal.Retina Eye Care of Nepal (RECON) project was designed to strengthen retina eye care in Nepal. Methods: RECON was implemented from May 2016 to February 2019 in Nepal. Four Master Eye Doctors (MED) received Training of Trainers (TOT) from Tokushima University, Japan. MEDs developed training materials for different cadres of ophthalmic human resources, enhanced retina eye care facilities, and conducted retina-screening camp in Nepal. Result: Twenty ophthalmologists, 16 optometrists, 48 ophthalmic assistants and 17 ophthalmic nurses, 76 physicians and 28 health workers were trained in retina care. Eight outreach retina camps were conducted. Conclusion: The project was a novel approach to strengthen retina services in Nepal. The aim of the project was accomplished with the ultimate benefits to the needy retina patients who otherwise were going to miss the retina services.
Atherogenic index of plasma is associated with the severity of Hidradenitis Suppurativa: a case-control study
Authors: Hernández José Luis , Baldeón Cristina , López-Sundh Ana Elísabet , Ocejo-Vinyals J Gonzalo , Blanco Ricardo , González-López Marcos Antonio 
Published: August 2020

Abstract
Background. Hidradenitis suppurativa (HS) is a chronic inflammatory disease associated with several comorbidities and vascular risk factors, such as dyslipidemia. The present study aimed to assess the possible associations between the lipid profile and atherogenic indexes and the severity of HS. Methods. This case-control study enrolled 78 HS patients and 62 healthy controls. Classic lipid profile and lipoprotein ratios, including the atherogenic index of plasma (AIP), were evaluated. The severity of HS was measured by the HS Physician Global Assessment (PGA). Results. HS-patients had lower serum total cholesterol and HDL-C levels and higher AIP than the control group. AIP was positively correlated to BMI, waist circumference, systolic and diastolic blood pressure, LDL-C, triglycerides, non-HDL-C, ApoB, HOMA, and hs-CRP and negatively to HDL-C and ApoA1. For the overall lipid profile, only AIP was related to a more severe HS (PGA≥3) after controlling for age, sex, BMI, insulin resistance (IR), active smoking, and statin use (r=0.268; p=0.023). Multiple logistic regression adjusted for age, sex, BMI, IR, smoking status and statin use, showed that AIP≥0.5 was significantly associated with the severity of HS (OR, 4.38; CI 95%, 1.09-17.50; p=0.037). Conclusions. In conclusion, these results showed that AIP is significantly and independently associated with HS severity.