bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experiences of Social Distancing During Coronavirus Disease 2019 as a Catalyst for Changing Long-Term Care Culture
Authors: Leaman Marion C. , Azios Jamie H. 
Published: January 2021

Purpose
In this article, we draw a parallel between the experience of social isolation that occurred throughout the world during the Coronavirus Disease 2019 pandemic and similar experiences occurring in everyday life for people with communication disorders living in long-term care (LTC) facilities. We propose that speech-language pathologists can use the widespread experience of social isolation as a learning catalyst in the effort to shift the LTC culture to one that more highly values a communicative environment that is accessible to all, thereby reducing risk of social isolation for those with communication disorders.

Conclusions
Many training paradigms for promoting an accessible communicative environment are available in the speech-language pathology literature, yet institutional barriers exist for their widespread implementation. Overcoming these barriers is a challenge that requires awareness and learning on the part of staff and administration regarding the impact of an unfriendly communicative environment on social isolation, and the resulting psychosocial consequences. Learning theory indicates that new learning in adults is motivated by connections between personal experiences and the material to be learned. Explicitly infusing established training programs with the experience of social isolation brought on by the Coronavirus Disease 2019 pandemic may be the key needed for changing the communicative environment in LTC.
Cognitive Processing of Miscommunication in Interactive Listening: An Evaluation of Listener Indecision and Cognitive Effort
Authors: Roche Jennifer M. , Zgonnikov Arkady , Morett Laura M. 
Published: January 2021

Purpose
The purpose of the current study was to evaluate the social and cognitive underpinnings of miscommunication during an interactive listening task.

Method
An eye and computer mouse–tracking visual-world paradigm was used to investigate how a listener's cognitive effort (local and global) and decision-making processes were affected by a speaker's use of ambiguity that led to a miscommunication.

Results
Experiments 1 and 2 found that an environmental cue that made a miscommunication more or less salient impacted listener language processing effort (eye-tracking). Experiment 2 also indicated that listeners may develop different processing heuristics dependent upon the speaker's use of ambiguity that led to a miscommunication, exerting a significant impact on cognition and decision making. We also found that perspective-taking effort and decision-making complexity metrics (computer mouse tracking) predict language processing effort, indicating that instances of miscommunication produced cognitive consequences of indecision, thinking, and cognitive pull.

Conclusion
Together, these results indicate that listeners behave both reciprocally and adaptively when miscommunications occur, but the way they respond is largely dependent upon the type of ambiguity and how often it is produced by the speaker.
Longitudinal Changes in Auditory and Cognitive Function in Middle-Aged and Older Adults
Authors: Humes Larry E. 
Published: January 2021

Purpose
This article aimed to document longitudinal changes in auditory function, including measures of temporal processing, and to examine the associations between observed changes in auditory and cognitive function in middle-aged and older adults.

Method

This was a prospective longitudinal study of 98 adults (66 women) with baseline ages ranging from 40 to 85 years. The mean interval between T1 baseline and T2 follow-up measurements was 8.8 years with a range of 7–11 years. Measures of hearing threshold, gap detection, and auditory temporal-order identification were completed at T1 and T2. Cognitive measures completed at T1 and T2 were the 13 scales of the Wechsler Adult Intelligence Scale–Third Edition. Three approaches were taken to analyze these data: (a) examination of changes over time in group performance, (b) correlations and slopes between auditory and cognitive measures to examine concomitant
rates
of decline over the 9-year T1-to-T2 period, and (c) regression analyses examining associations between auditory performance at T1 and cognitive performance 9 years later at T2.

Results
For the group data, there were significant declines in hearing loss, gap-detection thresholds at one frequency, and process-type measures of cognitive function from T1 to T2 matching the trends in the baseline cross-sectional data. Regression analyses of the longitudinal data revealed the strongest connection between auditory temporal-order processing and cognitive processing typically explaining 10%–15% of the variance.

Conclusions
A significant amount of variance in rates of cognitive decline, T1 to T2, and subsequent cognitive performance (T2) was explained by measures of auditory function. Although hearing loss occasionally emerged as a significant factor, auditory temporal-order identification emerged much more frequently as the auditory measure most strongly associated with cognitive function.
Quality of service (QoS) for LTE network based on adaptive neuro fuzzy inference system
Authors: Nafea Hala B. , Aboelezz Zeinab A. , Zaki Fayez W. 
Published: January 2021

AbstractThe main objective of this paper is to design an Adaptive Neuro Fuzzy Inference System model to calculate the quality of service for LTE HetNet applications. The quality of service parameters considered are delay, loss rate, throughput, and jitter. The adaptive neuro fuzzy inference system is an integration of fuzzy logic and neural network. The advantage of neural network in adaptive neuro fuzzy inference system is to train the neural network algorithm on the parameter values of membership function for fuzzy logic to construct fuzzy decision. So, adaptive neuro fuzzy inference system gives better performance than fuzzy logic alone for LTE network applications (e.g. VOIP, HTTP, VIDEO, and EMAIL). The results based on adaptive neuro fuzzy inference system model produce high quality of service for LTE network applications as compared with fuzzy logic alone. It is also found that adaptive neuro fuzzy inference system results in EMAIL and quality of service outperform fuzzy logic alone by about 28.7% at medium delay, low loss rate, jitter, and high throughput.
Multi‐antenna joint covert communication with a public communication link over wireless fading channel
Authors: Lin Yuda , Jin Liang , Huang Kaizhi , Zhou You 
Published: January 2021

AbstractThis paper studies multi‐antenna covert communication exploiting a public communication link over the wireless fading channel. In particular, a relatively practical covert communication scenario is considered for the first time, where a warden with radiometer may improve its detection accuracy by jointly detecting uplink covert pilot and downlink covert communication. To this end, a joint covert communication system, jointly considering uplink covert pilot, imperfect channel state information issue and downlink covert communication, is proposed and further studied. Specifically, the detection performance of warden and the covertness performance of system are comprehensively studied, respectively. Afterwards, an optimization problem for covert capacity is formulated to maximize overall performance. Then, with our analysis and simplification, an optimal power allocation algorithm is designed for covert capacity accordingly. Our examination shows a win‐win situation has been achieved in the proposed system, that is, covert communication would rarely affect the normal communication of public link and occupy its communication resources. Interestingly enough, we analytically find an invariance property of downlink covert communication that covertness performance is not impacted by noise levels or warden's position. Based on this extraordinary finding, we conclude that the downlink covert communication system can perfectly combat with a powerful warden adopting power trend test method, while the joint covert communication system may resist that through a pilot deception scheme.
Toward Cosmicflows-4: The HI data catalog
Authors: Dupuy A. , Courtois H. M. , Guinet D. , Tully R. B. , Kourkchi E. 
Published: January 2021

Aims. In this study, we present an update of a compilation of line width measurements of neutral atomic hydrogen (HI) galaxy spectra at 21 cm wavelength. Our All Digital HI (ADHI) catalog consists of the previous release augmented with our new HI observations and an analysis of archival data. This study provides the required HI information to measure the distances of spiral galaxies through the application of the Tully-Fisher (TF) relation.
Methods. We conducted observations at the Green Bank telescope (GBT) and reprocessed spectra obtained at the Nançay radiotelescope by the Nançay Interstellar Baryons Legacy Extragalactic Survey and Kinematics of the Local Universe collaborations and we analyzed the recently published full completion Arecibo Legacy Fast ALFA (ALFALFA) 100% survey in order to identify galaxies with good quality HI line width measurements.
Results. This paper adds new HI data adequate for TF use for 385 galaxies observed at GBT, 889 galaxies from archival Nançay spectra, and 1515 rescaled Arecibo ALFALFA spectra. In total, this release adds 1274 new good quality measurements to the ADHI catalog. Today, the ADHI database contains 18 874 galaxies, for which 15 433 have good quality data for TF use. The final goal is to compute accurate distances to spiral galaxies, which will be included in the next generation of peculiar velocities catalog: Cosmicflows-4.
Die Tumorstammzellnische im Kopf-Hals-Bereich – Knotenpunkt mit therapeutischem Potenzial?
Authors: Lammert Anne , Affolter Annette , Gvaramia David , Heid Jonas , Jungbauer Frederic , Scherl Claudia , Tenschert Esther , Rotter Nicole , Willett Nicola , Kern Johann 
Published: January 2021

ZusammenfassungIn den letzten Jahren verdichten sich Hinweise, dass eine Tumorstammzellpopulation in Plattenepithelkarzinomen der Kopf-Hals-Region (HNSCC) existiert. Man vermutet, dass diese Tumorstammzellen (CSC) über Selbsterneuerungskapazität verfügen und für Wachstum, Metastasierung, Rekurrenz und Therapieresistenz des Tumors essenziell sind. Stammzellen werden von einer spezialisierten zellulären und nichtzellulären Mikroumgebung unterstützt, die „Stammzellnische“ genannt wird. Eine mögliche Strategie, um CSC zu attackieren, könnte eine Beeinflussung ihrer Nische sein.Stromal cell-derived factor-1 (SDF-1) gilt als Schlüsselregulator des Zellverkehrs zwischen Nische und der peripheren Blutzirkulation. SDF-1 ist ein multifunktionelles Zytokin, das u. a. von Endothel-/Stromazellen sezerniert wird. Als sein Rezeptor wurde der 7-Transmembranrezeptor CXCR4 identifiziert. Die SDF-1-CXCR4-Achse ist ein wesentlicher Faktor für Migration und Mobilisation von CSC in und aus ihrer Nische. Ihre Existenz und Funktionalität in der Tumorstammzellnische von HNSCC konnte bereits nachgewiesen werden. Strategien, die in diese Interaktion eingreifen, könnten einen entscheidenden Beitrag in der Therapie von HNSCC bieten.Um Mechanismen in der Tumorstammzellnische von HNSCC in vitro zu untersuchen, werden Modelle benötigt. Wir erwarten, dass die 3D-Zellkultur und das 3D-Bioprinting bei der Entwicklung neuer, individualisierter Therapiestrategien bahnbrechenden Charakter aufweisen werden.Hier geben wir eine Übersicht über den Wissensstand hinsichtlich der Interaktionen in der Tumorstammzellnische von HNSCC am Beispiel der SDF-1-CXCR4-Achse.
Development of a Physiologically-Based Pharmacokinetic (PBPK) Model of Nebulized Hydroxychloroquine for Pulmonary Delivery to COVID-19 Patients
Authors: Idkaidek Nasir , Hawari Feras , Dodin Yasmeen , Obeidat Nour 
Published: January 2021

AbstractDespite inconclusive evidence, chloroquine (CQ) and hydroxychloroquine (HCQ)are commonly used for the treatment of Corona virus Disease 2019(COVID-19) in critically ill patients.It was hypothesized that HCQ as an aerosol application can reach the antiviral concentration of ~1–5 μM in the alveolar cells which has been proven effective in vitro. A physiologically-based pharmacokinetic (PBPK) model of nebulized HCQ for pulmonary delivery to COVID-19 patients using the Nasal-Pulmonary Module in GastroPlus® V9.7 simulator, in order to calculate the necessary inhalation dose regimen of HCQ, was developed. The physiological, drug disposition, and pharmacokinetic parameters were obtained from the literature and used during model building after optimization using Optimization Module, while oral data was used for validation. The 25 mg BID inhalation dosing was predicted to lead to alveolar HCQ levels of 7 µM (above EC50 of ~1–5 µM), and small plasma levels of 0.18 µM (as compared to plasma levels of 3.22 µM after 200 mg BID oral dosing). However, average contact time (>1 µM) is around 0.5 h in lung parts, suggesting indirect exposure response effect of HCQ.The developed PBPK model herein predicted HCQ levels in plasma and different lung parts of adults after multiple inhalation dosing regimens for 5 days. This in-silico work needs to be tested in vivo on healthy subjects and COVID-19 patients using 12.5 mg BID and 25 mg BID inhalation doses.
Endoscopic full-thickness resection of polyps involving the appendiceal orifice: a multicenter international experience
Authors: Ichkhanian Yervant , Barawi Mohammed , Seoud Talal , Thakkar Shyam , Kothari Truptesh H. , Halabi Maan El , Ullah Asad , Edris Wedi , Aepli Patrick , Kowalski Thomas , Shinn Brianna , Shariaha Reem Z. , Mahadev Srihari , Mosko Jeffrey D. , Andrisani Gianluca , Di Matteo Francesco Maria , Albrecht Heinz , Giap Andrew Q. , Tang Shou-jiang , Naga Yehia M. , van Geenen Erwin , Friedland Shai , Tharian Benjamin , Irani Shayan , Ross Andrew S. , Jamil Laith H. , Lew Daniel , Nett Andrew S. , Farha Jad , Runge Thomas M. , Jovani Manol , Khashab Mouen A. 
Published: January 2021

Abstract
Background Endoscopic resection of lesions involving the appendiceal orifice remains a challenge. We aimed to report outcomes with the full-thickness resection device (FTRD) for the resection of appendiceal lesions and identify factors associated with the occurrence of appendicitis.
Methods This was a retrospective study at 18 tertiary-care centers (USA 12, Canada 1, Europe 5) between November 2016 and August 2020. Consecutive patients who underwent resection of an appendiceal orifice lesion using the FTRD were included. The primary outcome was the rate of R0 resection in neoplastic lesions, defined as negative lateral and deep margins on post-resection histologic evaluation. Secondary outcomes included the rates of: technical success (en bloc resection), clinical success (technical success without need for further surgical intervention), post-resection appendicitis, and polyp recurrence.
Results 66 patients (32 women; mean age 64) underwent resection of colonic lesions involving the appendiceal orifice (mean [standard deviation] size, 14.5 (6.2) mm), with 40 (61 %) being deep, extending into the appendiceal lumen. Technical success was achieved in 59/66 patients (89 %), of which, 56 were found to be neoplastic lesions on post-resection pathology. Clinical success was achieved in 53/66 (80 %). R0 resection was achieved in 52/56 (93 %). Of the 58 patients in whom EFTR was completed who had no prior history of appendectomy, appendicitis was reported in 10 (17 %), with six (60 %) requiring surgical appendectomy. Follow-up colonoscopy was completed in 41 patients, with evidence of recurrence in five (12 %).
Conclusions The FTRD is a promising non-surgical alternative for resecting appendiceal lesions, but appendicitis occurs in 1/6 cases.
Effect of Anabolic–Androgenic Steroid Abuse on the Contact Activation System
Authors: Sidelmann Johannes Jakobsen , Gram Jørgen Brodersen , Palarasah Yaseelan , Rasmussen Jon Jarløv , Kistorp Caroline 
Published: January 2021

AbstractThe effect of anabolic–androgenic steroid (AAS) abuse on the contact activation system (CAS) is not known in detail. We hypothesized that current AAS abuse reduces the kallikrein-generating capacity of CAS significantly and investigated the impact of AAS on the proteins and capacity of CAS in current and former AAS abusers and healthy age-matched controls. Men 18 to 50 years of age were included as current AAS abusers, former AAS abusers, or controls. Blood samples were collected after overnight fasting. Kallikrein generation (lag time, peak height, and endogenous kallikrein potential [EKP]), coagulation factor XII (FXII), prekallikrein, high-molecular-weight kininogen (HK), and Complement C1 esterase inhibitor (C1inh) were assessed. Groups were compared by analysis of variance or Kruskal–Wallis test and probabilities were corrected for multiple comparisons. Associations were evaluated by linear regression models. The EKP was significantly reduced in current (n = 37) AAS abusers (984 ± 328 nmol/L × min) compared with former (n = 33) abusers (1,543 ± 481 nmol/L × min) and controls (n = 30) (1,521 ± 339 nmol/L × min), p < 0.001. Current abusers had higher levels of FXII and C1inh and lower levels of prekallikrein and HK than controls, p ≤ 0.025. Stepwise regression analysis showed that EKP was associated with C1inh and prekallikrein in current AAS abusers, R
2 = 0.70, p < 0.001. We conclude that current AAS abuse reduces the kallikrein-generating capacity of CAS by increasing the concentration of C1inh and reducing the concentration of prekallikrein. These changes may contribute to the anti-inflammatory effect of testosterone.
Regioselective Oxidative Cross-Coupling Reaction: Synthesis of Imidazo[1,2-a]pyridine Fluorophores
Authors: Chu Xianglong , Niu Yadi , Ma Chen , Wang Xiaodong , Lin Yunliang , Li Fuwei 
Published: January 2021

AbstractA rapid access to a series of N-heteroarene fluorophores has been developed on the basis of the palladium-catalyzed direct oxidative C–H/C–H coupling of imidazo[1,2-a]pyridines with thiophenes/furans. The photophysical properties–structure relationship was systematically investigated. The resulting N-heteroarene fluorophores present color-tunable emissions (λem: 431–507 nm in CH2Cl2) and high fluorescence quantum yields (up to 91% in CH2Cl2).
Rhodium(III)-Catalyzed C–H Activation: Annulation of Petrochemical Feedstocks for the Construction of Isoquinolone Scaffolds
Authors: Patman Ryan L. , Barber Joyann S. , Kong Dehuan , Li Wei , McAlpine Indrawan J. , Nair Sajiv K. , Sakata Sylvie K. , Sun Nicole 
Published: January 2021

AbstractWe describe a simple and robust procedure for the Rh(III)-catalyzed [4+2] cycloaddition of feedstock gases enabled through C–H activation. A diverse set of 3,4-dihydroisoquinolones and 3-methylisoquinolones have been prepared in good to excellent yields. The effects of using ethylene and propyne as coupling partners on C–H site selectivity have also been explored with a representative set of substrates and are discussed herein.
Data Collection during the COVID-19 Pandemic: Learning from Experience, Resulting in a Bayesian Repertory
Authors: Rutten Lex , Smedley Tom , Ives Galen , Gold Peter , Merizalde Bernardo , van Haselen Robbert , Manchanda Raj Kumar , Ross Ashley , Cataldi Gustavo , Agaoglu Altunay , di Giampietro Tiziana , Lilas Theodore , Schroyens Frederik , Eizayaga José E. 
Published: January 2021

Abstract
Background A novel pandemic disease offered the opportunity to create new, disease-specific, symptom rubrics for the homeopathic repertory.
Objective The aim of this study was to discover the relationship between specific symptoms and specific medicines, especially of symptoms occurring frequently in this disease.
Materials and Methods Worldwide collection of data in all possible formats by various parties was coordinated by the Liga Medicorum Homeopathica Internationalis. As the data came in, more symptoms were assessed prospectively. Frequent analysis and feedback by electronic newsletters were used to improve the quality of the data. Likelihood ratios (LRs) of symptoms were calculated. An algorithm for combining symptom LRs was programmed and published in the form of an app. The app was tested against 18 well-described successful cases from Hong Kong.
Results LRs of common symptoms such as ‘Fatigue’ and ‘Headache’ provided better differentiation between medicines than did existing repertory entries, which are based only on the narrow presence or absence of symptoms. A mini-repertory for COVID-19 symptoms was published and supported by a web-based algorithm. With a choice of 20 common symptoms, this algorithm produced the same outcome as a full homeopathic analysis based upon a larger number of symptoms, including some that are traditionally considered more specific to particular medicines.
Conclusion A repertory based on clinical data and LRs can differentiate between homeopathic medicines using a limited number of frequently occurring epidemic symptoms. A Bayesian computer algorithm to combine symptoms can complement a full homeopathic analysis of cases.
Increasing the Awareness of Autism Spectrum Disorder with Training of Pre-School Teachers and School Counselors in Turkey
Authors: Kara Halil , Demirtaş Mehmet Semih 
Published: January 2021

AbstractTraining programs for the awareness of autism for professions are supported under the leadership of the United Nations. Misinformation can cause socially destructive results as that which is incorrect is assumed to be known correctly. This study included a total of 308 participants comprising 226 (73.4%) preschool teachers and 82 (26.6%) school counselors. The basic questions related to the awareness and knowledge of autism spectrum disorder (ASD) were selected based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and the Autism Diagnostic Observation Schedule, Second Edition (ADOS-2). It was attempted to categorize the questions into four fields: (1) social interaction, (2) social communication and speech, (3) limited interest pattern with stereotypical and ritualistic behaviors, and (4) comorbidities, etiological characteristics, and the relationship between vaccinations and autism. The results of the study indicate that the awareness of ASD, including core symptoms, was extremely lacking in preschool teachers and school counselors. Moreover, they had extreme prejudice to information known to be incorrect.