bluuebunny/crossref_metadata_2025_split huggingface dataset:
IT governance impact on financial reporting quality using COBIT framework
Authors: Haouam Djemaa 
Published: May 2020

The aim of this study is to demonstrate the impact of the application of information technology governance (COBIT) on the quality of financial reporting. To achieve the objectives of this study, we used the analytical descriptive approach to study the theoretical and practical studies in the subject with an extrapolation of the main results and presentation of them in order to increase the quality of the financial reports. The study found that there is a correlation between IT governance and the COBIT framework in its four dimensions on the quality of financial reporting. It has been shown that there is a positive relationship between these dimensions and the quality characteristics of financial reporting.
Keywords: IT governance (ITG), accounting information quality, corporate governance, quality of financial reporting, COBIT.
Value of Performing a Rasch Analysis on a Reliable and Valid Instrument—Case Study of the SA-SH
Authors: Areskoug-Josefsson Kristina , Rolander Bo 
Published: May 2020

Background and PurposeThe aim of this study was to explore the potential added value of performing a Rasch analysis on a reliable and valid instrument employed in nursing research and educational interventions, using the Students' Attitudes toward Sexual Health (SA-SH) as an example.MethodsThis study was performed with a polytomous Rasch model.ResultsThe Rasch analysis confirmed the reliability and validity of the SA-SH. Rasch analysis presented information about the item's individual response options and gave the opportunity to judge how well different answers alternated in an item. The Rasch analysis also provided information about the proportion of extremes and the possibility of excluding these.ConclusionsThe Rasch analysis provides added value regarding information that needs to be considered regarding choices of questionnaire literacy compared to item fit. The SA-SH is also valid and reliable when tested with Rasch analysis.
ELASTISITAS HARGA TERHADAP PENAWARAN OUTPUT DAN PERMINTAAN INPUT USAHATANI JAGUNG DI KABUPATEN GROBOGAN, JAWA TENGAH
Authors: Sahara Dewi , Suhendrata Tota 
Published: May 2020

Permintaan jagung cenderung meningkat, namun harganya juga relatif berfluktuasi. Penelitian ini bertujuan untuk mengetahui pengaruh perubahan harga output dan harga input terhadap penawaran jagung dan permintaan input produksi. Kegiatan dilaksanakan pada bulan September – Nopember 2016 dengan metode survey terhadap 30 petani jagung di Desa Boloh, Kecamatan Toroh, Kabupaten Grobogan. Data yang dikumpulkan meliputi data karakteristik rumah tangga, jumlah dan harga input, jumlah dan harga jagung. Data dianalisis dalam bentuk pangsa biaya menggunakan metode <em>Seemingly Unrelated Regression</em> (SUR). Hasil penelitian menunjukkan bahwa penawaran output terhadap harga sendiri bersifat elastis dengan tanda positif, sedangkan terhadap harga input bertanda negatif dan bersifat inelastis, kecuali terhadap permintaan pupuk Urea. Elastisitas permintaan input terhadap harga sendiri bertanda negatif dan inelastis kecuali terhadap permintaan pupuk Urea dan tenaga kerja bersifat elastis, sedangkan terhadap harga input lainnya besaran dan tandanya bervariasi. Luas areal tanam bersifat inelastis terhadap permintaan input produksi. Demikian pula dengan pendidikan dan pengalaman usahatani bersifat inelastis kecuali terhadap permintaan tenaga kerja bersifat elastis. Oleh karena itu untuk meningkatkan produksi jagung dapat dilakukan dengan meningkatkan harga jagung, memperluas areal tanam dan meningkatkan kapabilitas sumberdaya petani.
Jejunal inflammatory cytokines, barrier proteins and microbiome-metabolome responses to early supplementary feeding of Bamei suckling piglets
Authors: Jipeng Jin , Jia Jianlei , Zhang Liping , Chen Qian , Zhang Xiaoyan , Sun Weibo , Ma Cunming , Xu Fafang , Zhan Shoujun , Ma Limin , Zhou Guihua , Chen Qiaoxi 
Published: May 2020

Abstract
Background: Dietary intervention has been reported to improve intestinal health. The intestinal microbiota of newborn animals plays a fundamental role in the development of intestinal function and the innate immune system. However, little is currently known about dietary interventions in the gut microbiota and barrier function of livestock, especially suckling Bamei piglets. To this end, we studied the effect of early dietary supplementation on intestinal bacterial communities and intestinal barrier function in piglets.Results: 10 purebred Bamei sows were randomly allocated into two groups. In group one, the piglets received a supplementary milk replacer on day 7 of age, whereas the other control group was allowed sow’s milk alone. At 21 days, 18 and 17, respectively, piglets in each group of average weight were randomly selected and sacrificed. Tissue and digesta samples were collected from the jejunum to evaluate differences in the microbiome-metabolome and the mRNA expression of inflammatory cytokines (TLR4, TNFα and IL-8) and barrier proteins (ZO-1, Occludin and Claudin-1). Sequencing of 16S rRNA revealed that ES improved the gut microbiome composition of Bamei suckling piglets. The relative abundances of some bacterial species such as Lactobacillales, Romboutsia, Actinobacillus, Bacteroides were significantly reduced in the ES group. Metabolomics analysis indicated that 23 compounds were enriched and 35 compounds decreased in the ES group. And correlation analysis demonstrated that some gut bacterial genera were highly correlated with altered gut microbiota-related metabolites. Meanwhile, ES of Bamei suckling piglets altered the gene expression of inflammatory cytokine and barrier protein in the jejunum. Conclusions: In summary, these results provide important insights on the relationships between jejunal microbiota and related metabolites, and jejunal barrier function during the early life of Bamei suckling piglets.
Inhibition of lipogenesis and induction of apoptosis by valproic acid in prostate cancer cells via the C/EBPα/SREBP-1 pathway
Authors: Pang Bo , Zhang Juanjuan , Yuan Jihong , Shi Yanan , Qiao Ling 
Published: May 2020

Abstract
Background: Lipid metabolism reprogramming is now accepted as a new hallmark of cancer. Hence, targeting the lipogenesis pathway may be a potential avenue for cancer treatment. Valproic acid (VPA) emerges as a promising drug for cancer therapy, however, the underlying mechanisms are not yet fully understood. This study aimed to investigate the effects and mechanisms of VPA on cell viability, lipogenesis, and apoptosis in human prostate cancer PC-3 cells.Methods: The effects of VPA on the viability of PC-3 cells were investigated using MTT cell viability assay and wound-healing assay. Oil-Red O staining was used to examine lipid droplets, and DAPI staining assay and Annexin V-FITC and PI double-staining assay were used to measure the extent of cell apoptosis. Quantitative real-time PCR and Western blotting were used to determine the expression of lipogenesis and apoptosis genes. Statistical and analytical data were analyzed with SPSS 17.0 Software, and statistical significance was set to *P < 0.05, **P < 0.01, and ***P < 0.001 levels.Results: The results showed that VPA significantly reduced lipid accumulation and induced apoptosis of PC-3 cells. Moreover, the expression of CCAAT/enhancer-binding protein α (C/EBPα), as well as sterol regulatory element binding protein 1 (SREBP-1) and its downstream effectors, including fatty acid synthase (FASN), acetyl CoA carboxylase 1 (ACC1), and antiapoptotic B cell lymphoma 2 (Bcl-2), markedly decreased in PC-3 cells after VPA administration. Mechanistically, the overexpression of C/EBPα rescued the levels of SREBP-1, FASN, ACC1, and Bcl-2, enhanced lipid accumulation and attenuated apoptosis of VPA-treated PC-3 cells. Conversely, knockdown of C/EBPα by siRNA further decreased lipid accumulation, enhanced apoptosis, and reduced the levels of SREBP-1, FASN, ACC1, and Bcl-2. In addition, SREBP-1a and 1c enhanced the expression of FASN and ACC1, but only SREBP-1a had a signiﬁcant eﬀect on Bcl-2 expression in VPA-treated PC-3 cells.Conclusions: On the whole, it is concluded that VPA significantly inhibits cell viability via decreasing lipogenesis and inducing apoptosis via the C/EBPα/SREBP-1 pathway in PC-3 cells. Therefore VPA which targets lipid metabolism and apoptosis is a promising candidate for prostate cancer chemotherapy.
WITHDRAWN: Grassland utilization estimation method and system based on environmental sense
Authors: Wang Chuanjian , Li Dong , Yan Tianying , Wang Qilei , Wang Ju , Bing Wanlong 
Published: May 2020

Abstract
The utilization of natural grassland is an important part of grazing animal husbandry. Effective monitoring and accurate estimation of the utilization of natural grassland are inevitable requirements for the sustainable development of grazing animal husbandry. In order to estimate the utilization process of natural grassland effectively, this paper proposes a grassland utilization estimation method based on environmental sense. In this paper, the distribution of feed intake was obtained by the GPS trajectory data, and the distribution of grassland biomass was obtained by the satellite remote sensing estimation model of natural grassland. The feed intake and grassland biomass are classified and compared respectively. According to the value of the two, the utilization of grassland in each region was obtained. And this study designed a grassland utilization estimating system based on this estimating method and 3S technology. The results show that this method is of great significance to the rational utilization of grassland and the implementation of rotational grazing. The system can provide decision-making basis for ranchers and grassland livestock management departments to manage grazing and grassland. It enables ranchers to make reasonable and effective grazing plans, so as to make balanced utilization of grassland resources and promote the sustainable development of grazing animal husbandry.
Cox-maze III Procedure for Atrial Fibrillation during Valve Surgery: A Single Institution Experience
Authors: Wang Changtian , Zhang Lei , Qin Tao , Xi Zhi-long , Sun Lei , Wu Hai-wei , Li De-min 
Published: May 2020

Abstract
Objectives: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in patients with heart valve disease. Our aim was to summarize our experience and evaluate the efficacy and safety of the Cox maze III procedure combined with valve surgery in patients with AF. Methods: A retrospective, observational analysis was performed for all consecutive patients underwent maze III procedure combined with valve surgery between October 2015 and June 2019. In this trial, we used a monopolar radiofrequency (RF) ablation in addition to cut and sew technique to treat AF.Results: 66 patients (37 female, 56.1%) with persistent or long-lasting persistent AF associated with valve disease were identified. The mean age was 54.2±8.4 years (range, 30 to 73 years). Overall hospital mortality was 3.0%. The duration of cardiopulmonary bypass and aortic cross clamping was 175.4±32.9 and 115.6±22.8 minutes respectively. The first 24hours drainage was 488.6±293.3ml. The postoperative hospital stay was 14.8±8.3 days. The postoperative incidence of permanent pacemaker implantation, reoperation for bleeding, renal failure required hemodialysis, and stroke was 4.5%, 1.5%, 4.5% and 0 respectively. The frequency of sinus rhythm was 91.7%, 93.1%, 94.7%, 93.3% and 89.5% at 1, 3, 6, 12, and 24 months respectively.Conclusions: The Cox-Maze III procedure is safe in the surgical treatment of AF associated with valve disease, and efficacious for sinus rhythm maintenance, with low morbidity and mortality.
“Apple does not fall far from the tree” – subclinical atherosclerosis in children with familial hypercholesterolemia.
Authors: Podgórski Michał , Szatko Katarzyna , Stańczyk Małgorzata , Pawlak-Bratkowska Monika , Konopka Agnieszka , Starostecka Ewa , Tkaczyk Marcin , Góreczny Sebastian , Rutkowska Lena , Gach Agnieszka , Łukaszewski Maciej , Grzelak Piotr , Banach Maciej 
Published: May 2020

Abstract
Background: Familial hypercholesterolemia (FH) increases the risk of atherosclerosis in children and adults. Atherosclerotic cardiovascular disease in young patients FH is usually subclinical but recognition of children with more pronounced changes is crucial for adjusting effective management. Aim of this research was to use ultrasonography with two-dimensional speckle tracking (2DST) and tonometry to evaluate atherosclerotic changes in patients with FH (parents and their offspring).Methods: Applanation tonometry and carotid arteries sonography with evaluation of the intima-media complex thickness (IMCT) and application of the 2DST were performed in 20 families with FH (20 parents and 29 children). The same size control group (age and sex matched) was included. Results were compared between peers and between generations together with the correlation analysis.Results: Adults with FH, in comparison with healthy peers, presented significantly more atherosclerotic plaques (9 vs. 2, p=0.0230), had significantly thicker IMC (0.84±0.19 vs. 0.56±0.06 mm, p<0.0001) and had stiffer arterial wall (for stain: 6.25±2.3 vs. 8.15±2.46, p=0.0103). In children from both groups there were no atherosclerotic plaques and IMCT did not differ significantly (0.42±0.07 vs. 0.39±0.04, p=0.1722). However, children with FH had significantly stiffer arterial wall according to 2DST (for strain: 9.22±3.4 vs. 11.93±3.11, p=0.0057) and tonometry (for the pulse wave velocity: 4.5±0.64 vs.3.96±0.62, p=0.0047). These parameters correlated with atherosclerosis surrogates in their parents (p<0.001) but were not significantly affected by presence of presumed pathogenic gene variant.Conclusions: Children with FH presented subclinical atherosclerosis manifested as decreased arterial wall elasticity. Degree of stiffening was associated with advancement of atherosclerosis in their parents but did not present significant association with gene variants. Sonography with application of 2DST seems to be a good candidate for comprehensive evaluation of atherosclerosis in families with FH.
The impact of immunotherapy on the survival of pancreatic adenocarcinoma patients who received definitive surgery of the pancreatic tumor: A retrospective analysis of the National Cancer Database
Authors: Amin Saber , Baine Michael , Meza Jane , Alam Morshed , Lin Chi 
Published: May 2020

Abstract
Background: Immunotherapy has paved the way for new therapeutic opportunities in cancer but has failed to show any efficacy in Pancreatic Adenocarcinoma (PDAC), and its therapeutic role remains unclear. The objective of this study is to examine the impact of immunotherapy in combination with chemotherapy, RT, and chemoradiation on the overall survival (OS) of PDAC patients who received definitive surgery of the tumor using the National Cancer Database (NCDB). Methods: Patients with PDAC who received definitive surgery of the pancreatic tumor and were diagnosed between 2004 and 2016 from the NCDB were identified. Cox proportional hazard analysis was used to assess the survival difference between patients who received chemotherapy plus immunotherapy and chemoradiation therapy plus immunotherapy and their counterparts who only receive these treatments without immunotherapy. The multivariable analysis was adjusted for age of diagnosis, race, sex, place of living, income, education, treatment facility type, insurance status, year of diagnosis, and treatment types such as chemotherapy and radiation therapy. Results: In total, 63,154 PDAC patients who received definitive surgery of the tumor were included in the analysis. Among the 63,154 patients, 636 (1.01%) received immunotherapy. Among patients who received chemotherapy (21,355), and chemoradiation (21,875), 157/21,355 (0.74%) received chemotherapy plus immunotherapy, and 451/21,875 (2.06%) received chemoradiation plus immunotherapy. Patients who received chemoradiation plus immunotherapy had significantly improved median OS compared to patients who only received chemoradiation with an absolute median OS benefit of 5.7 [29.31 vs. 23.66; p <0.0001] months. In the multivariable analysis, patients who received immunotherapy had significantly improved OS compared to patients who did not receive immunotherapy (HR: 0.90; CI: 0.81-0.99; P <0.039). Patients who received chemoradiation plus immunotherapy had significantly improved OS compared to their counterparts who only received chemoradiation without immunotherapy (HR: 0.85 CI: 0.75-0.95; P <0.008). Conclusions: In this study, the addition of immunotherapy to chemoradiation therapy was associated with significantly improved OS in PDAC patients who received definitive surgery. The study warrants further future clinical trials of immunotherapy in PDAC.
Peritumoral ductular reaction can be a prognostic factor for intrahepatic cholangiocellular carcinoma
Authors: Shen Zhenyang , Xiao Jingbo , Wang Junjun , Lu Lungen , Wan Xinjian , Cai Xiaobo 
Published: May 2020

Abstract
Background
Peritumoral ductular reaction (DR) was reported to be related to the prognosis of combined hepatocellular-cholangiocarcinoma and hepatocellular carcinoma. Non-mucin-producing intrahepatic cholangiocellular carcinoma (ICC), may be derived from small bile duct cells or liver progenitor cells (LPCs). However, whether peritumoral DR is also related to non-mucin-producing ICCs needs to be investigated.
Methods
Forty-seven patients with non-mucin-producing ICC were eventually included in the study. Clinicopathological variables were collected. Immunohistochemical analysis and immunofluorescence staining for cytokeratin 19, proliferating cell nuclear antigen, and α-smooth muscle actin were performed in tumor and peritumor liver tissues.
Results
Peritumoral DR is significantly correlated with local inflammation and fibrosis. Patients with significant peritumoral DR had high recurrence rate (81.8% vs 56.0%, P = 0.058) and poor overall and disease-free survival time (P = 0.01 and P = 0.03, respectively). Significant peritumoral DR showed high proliferation activity of LPC/cholangiocytes and abundant background extracellular matrix.
Conclusions
Patients with non-mucin-producing ICC having significant peritumoral DR had a poor prognosis. Peritumoral DR could be a prognostic factor for ICC; however, the mechanism should be further investigated.
Population status and feeding ecology of common bushbuck (Tragelaphus scriptus) in Moledo Forest, west Gojjam, Ethiopia
Authors: Sinshaw Aynalem , Tamene Mesele 
Published: May 2020

Abstract
Background Common Bushbuck (Tragelaphus scriptus) is one of the most widely distributed antelope species in African continent and use a wide variety of habitat types. A study on population status and feeding ecology of common bushbuck in Moledo Forest, West Gojjam, Ethiopia was carried out from September 2017 to August 2018 during wet and dry seasons. Data were collected using total count method and focal sampling technique. Then, the collected data were analyzed using descriptive statistics and compared with t-test for population status and percentage contribution of food items. Plant species consumed were compared with Chi-square test between seasons.Results The result indicated that the total numbers of bushbuck population were 18 and 28 during dry and wet seasons, respectively. There was a significant difference (t = 0.61, df = 4, p < 0.05) in bushbuck population during both seasons. Sex ratio of adult male to adult female was1.4:1. On the other hand, 20 plant species belonging to 11 families were recorded as food for study animal. Food items were significantly differed between seasons ({{\chi }}^{2}= 930.88, df = 1, p < 0.05). Their food items mainly constituted 50% shrub, 30% herb and 20% tree. Young leaves contributed to 40% of their diet followed by mature leaves 26%. On the other hand, flowers contributed the least (6%) for their diet. There was a significant variation ( {{\chi }}^{2} = 98, df = 10, p < 0.05) in parts of plant consumed by common bushbuck in the study area.Conclusion There are some threats associated with common bushbuck in the study area such as livestock grazing, habitat encroachment, fire wood collection, predation and hunting. Therefore, immediate attention needs to be paid to conserve the study animal in particular and other wildlife in general.
Train-the-Trainer Course for General Practitioners Identified Salient Points for Promoting Healthy Ageing – A Convergent Mixed-Methods Study
Authors: Yang Daya , Yuan Gang , Tang Hao , Hill Anne-Marie , Chen Wei , Wang Jingsong , Kuang Ming , Xiao Haipeng , Xu Dan 
Published: May 2020

Abstract
Background General practitioners (GPs) in China are playing an increasingly important role in geriatric care. In the context of GP training in geriatrics, the current study sought to explore the perception of local GP trainers regarding how GP training can better serve the purpose of healthy ageing promotion.Methods In this convergent mixed-methods design study, a convenience sample of local senior GP trainers were enrolled in a Train-the-Trainer (TTT) course in Guangzhou China. A series of lectures was conducted and followed by individual surveys via an on-line platform at the end of the course with participants providing quantitative and qualitative feedback. Course satisfaction ratings and salient points with respect to the gaps and needs for GP trainers were recorded regarding healthy ageing promotion.Results Participants (n=20) reported high levels of overall satisfaction with the course (91.3%), and rated the course as relevant (97.5%) and contemporary (up-to-date) (96.7%).Six geriatric-related topics were presented: (1) polypharmacy and de-prescribing, (2) dementia, (3) antibiotic stewardship, (4) fall prevention and frailty assessment, (5) vaccination, (6) atrial fibrillation. Participants identified salient points for inclusion into GP training programs in each topic. These salient learning points were categorized into personal, interpersonal, and societal domains. Conclusions The TTT course for GP trainers provided an excellent platform for academic exchange regarding healthy ageing promotion. Salient points identified from course feedback may inform future training, research and collaboration initiatives for GPs' roles as health advocate for the older adult population.