bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceived corporate social responsibility and pro‐environmental behaviors: The role of organizational identification and coworker pro‐environmental advocacy
Authors: Shah Syed Haider Ali , Cheema Sadia , Al‐Ghazali Basheer M. , Ali Muhammad , Rafiq Nosheen 
Published: September 2020

AbstractDespite research suggesting that pro‐environmental behaviors offer a range of positive benefits for organizations and that corporate social responsibility (CSR) positively affects employee behaviors and attitudes, very few studies have investigated how CSR affects pro‐environmental behaviours. As such, this study investigates the impact of perceived CSR on employees' pro‐environmental behaviours through organizational identification and coworkers' pro‐environmental advocacy. Using a multistage sampling technique, a survey of line managers was conducted across 32 hotels in the understudied context of Malaysia's hotel industry. Based on 331 completed questionnaires, the results suggest that perceived CSR activities drive organizational identification and trigger coworkers’ pro‐environmental advocacy, which in turn generate employees’ pro‐environmental behaviours. The study offers valuable insights into the complex relationship between perceived CSR and pro‐environmental behaviors and discusses the theoretical and research contributions and managerial implications.
Adaptive two‐stage spectrum sensing model using energy detection and wavelet denoising for cognitive radio systems
Authors: Fawzi Ahmed , El‐Shafai Walid , Abd‐Elnaby Mohammed , Zekry Abdelhalim , Abd El‐Samie Fathi E. 
Published: September 2020

SummaryThis paper presents an efficient adaptive two‐stage spectrum sensing model for the cognitive radio (CR) systems. The proposed model combines two well‐known techniques: energy detection (ED) and wavelet denoising (WD). The ED technique is employed to identify the existence of the primary user (PU) signal in the case of high signal‐to‐noise ratio (SNR) by comparing the received signal with a threshold. In the case of lowSNR, the ED technique alone cannot be adopted for decision making about the status of the PU due to the noise impact on the received signals. Hence, the stage of WD is exploited prior to the ED for reducing the noise effect and detecting the PU signal in the presence of noise. The detection performance of the proposed model is compared with those of the ED alone and the previous related two‐stage spectrum sensing methods. Simulation results show that the proposed model improves the false alarm rate compared to the ED alone by 36% and 6%, respectively, at lowSNRs of −15 and −20 dB. Also, the proposed model yields the smallest detection time compared to the previous two‐stage spectrum sensing methods. The proposed model can be used to minimize the probability of false alarm, achieve a better probability of detection, and improve the sensing process in CR systems.
Fluorescence polarisation for high‐throughput screening of adulterated food products via phosphodiesterase 5 inhibition assay
Authors: Mohd Yusop Ahmad Yusri , Xiao Linda , Fu Shanlin 
Published: September 2020

AbstractThe surge in the consumption of food products containing herbal aphrodisiacs has driven their widespread adulteration. A rapid screening strategy is, therefore, warranted to curb this problem. This study established an enzyme inhibition assay to screen phosphodiesterase 5 (PDE5) inhibitors as adulterants in selected food products. Fluorescein‐labelled cyclic‐3′,5′‐guanosine monophosphate was utilised as substrates for the PDE5A1 enzyme, aided by the presence of nanoparticle phosphate‐binding beads on their fluorescence polarisation. The sample preparation was optimised to improve the enzyme inhibition efficiency and applied to calculate the threshold values of six blank food matrices. The assay was validated using sildenafil, producing an IC50 of 4.2 nM. The applicability of the assay procedure was demonstrated by screening 55 distinct food samples. The results were subsequently verified using confirmatory liquid chromatography–high‐resolution mass spectrometry (LC‐HRMS) analysis. Altogether, 49 samples inhibited the PDE5 enzyme above the threshold values (75.7%–105.5%) and were registered as potentially adulterated samples. The remaining six samples were marked as nonadulterated with percentage inhibition below the threshold values (−3.3%–18.2%). The LC‐HRMS analysis agreed with the assay results for all food products except for the instant coffee premix (ICP) samples. False‐positive results were obtained for the ICP samples at 32% (8/25), due to possible PDE5 inhibition by caffeine. Contrarily, all other food samples were found to produce 0% (0/30) false‐positive or false‐negative results. The broad‐based assay, established via a simple mix‐incubate‐read format, exhibited promising potential for high‐throughput screening of PDE5 inhibitors in various food products, except those with naturally occurring phosphodiesterase inhibitors such as caffeine.
Effects of Hedysarum leguminous plants on soil bacterial communities in the Mu Us Desert, northwest China
Authors: Zhou Ziyuan , Yu Minghan , Ding Guodong , Gao Guanglei , He Yingying , Wang Genzhu 
Published: September 2020

AbstractThis study assessed the influence of rhizocompartment types (i.e., root, rhizosphere soil, root‐zone soil, and intershrub bulk soil) on the diversity of soil microbial communities under desert leguminous plant shrubs. Moreover, the influence and variations of soil physicochemical factors in interactions among leguminous plants, soil, and microbes were investigated. Both 16S rRNA high‐throughput genome sequencing and conventional soil physicochemical index determination were used to characterize both the bacterial diversity and soil physicochemical properties in the rhizocompartments of two Hedysarum species (Hedysarum mongolicum and Hedysarum scoparium) in the Mu Us Desert of China. All nutrient indices (except total phosphorus and available phosphorus) in rhizosphere soil were uniformly higher than those in both root‐zone soil and intershrub bulk soil (p < .05). The bacterial community diversity in the root, undershrub soil (i.e., rhizosphere and root zone), and intershrub bulk soil also showed significant differences (p < .05). The bacterial community in the root is mainly composed of Proteobacteria, Actinobacteria, Bacteroidetes, Tenericutes, and Chloroflexi, among which bacteria of the Proteobacteria genus are dominant. Root endophyte and rhizosphere soil microbiomes were mainly influenced by soil nutrients, while bacterial communities in root‐zone soil and intershrub bulk soil were mainly influenced by soil pH and NH4+‐N. The rhizocompartment types of desert leguminous plants impose a significant influence on the diversity of soil microbial communities. According to these findings, nitrogen‐fixing rhizobia can co‐exist with nonsymbiotic endophytes in the roots of desert leguminous plants. Moreover, plants have a hierarchical filtering and enriching effect on beneficial microbes in soil via rhizocompartments. Soil physicochemical factors have a significant influence on both the structure and composition of microbial communities in various rhizocompartments, which is derived from the interactions among leguminous plants, soil, and microbes.
Background insect herbivory increases with local elevation but makes minor contribution to element cycling along natural gradients in the Subarctic
Authors: Kristensen Jeppe A. , Michelsen Anders , Metcalfe Daniel B. 
Published: September 2020

AbstractHerbivores can exert major controls over biogeochemical cycling. As invertebrates are highly sensitive to temperature shifts (ectothermal), the abundances of insects in high‐latitude systems, where climate warming is rapid, is expected to increase. In subarctic mountain birch forests, research has focussed on geometrid moth outbreaks, while the contribution of background insect herbivory (BIH) to elemental cycling is poorly constrained. In northern Sweden, we estimated BIH along 9 elevational gradients distributed across a gradient in regional elevation, temperature, and precipitation to allow evaluation of consistency in local versus regional variation. We converted foliar loss via BIH to fluxes of C, nitrogen (N), and phosphorus (P) from the birch canopy to the soil to compare with other relevant soil inputs of the same elements and assessed different abiotic and biotic drivers of the observed variability. We found that leaf area loss due to BIH was ~1.6% on average. This is comparable to estimates from tundra, but considerably lower than ecosystems at lower latitudes. The C, N, and P fluxes from canopy to soil associated with BIH were 1–2 orders of magnitude lower than the soil input from senesced litter and external nutrient sources such as biological N fixation, atmospheric deposition of N, and P weathering estimated from the literature. Despite the minor contribution to overall elemental cycling in subarctic birch forests, the higher quality and earlier timing of the input of herbivore deposits to soils compared to senesced litter may make this contribution disproportionally important for various ecosystem functions. BIH increased significantly with leaf N content as well as local elevation along each transect, yet showed no significant relationship with temperature or humidity, nor the commonly used temperature proxy, absolute elevation. The lack of consistency between the local and regional elevational trends calls for caution when using elevation gradients as climate proxies.
African‐specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer
Authors: Karunamuni Roshan A. , Huynh‐Le Minh‐Phuong , Fan Chun C. , Thompson Wesley , Eeles Rosalind A. , Kote‐Jarai Zsofia , Muir Kenneth ,   UKGPCS Collaborators, Lophatananon Artitaya , Tangen Catherine M. , Goodman Phyllis J. , Thompson Ian M. , Blot William J. , Zheng Wei , Kibel Adam S. , Drake Bettina F. , Cussenot Olivier , Cancel‐Tassin Géraldine , Menegaux Florence , Truong Thérèse , Park Jong Y. , Lin Hui‐Yi , Bensen Jeannette T. , Fontham Elizabeth T. H. , Mohler James L. , Taylor Jack A. , Multigner Luc , Blanchet Pascal , Brureau Laurent , Romana Marc , Leach Robin J. , John Esther M. , Fowke Jay , Bush William S. , Aldrich Melinda , Crawford Dana C. , Srivastava Shiv , Cullen Jennifer C. , Petrovics Gyorgy , Parent Marie‐Élise , Hu Jennifer J. , Sanderson Maureen , Mills Ian G. , Andreassen Ole A. , Dale Anders M. , Seibert Tyler M. ,   The PRACTICAL Consortium
Published: September 2020

AbstractPolygenic hazard score (PHS) models are associated with age at diagnosis of prostate cancer. Our model developed in Europeans (PHS46) showed reduced performance in men with African genetic ancestry. We used a cross‐validated search to identify single nucleotide polymorphisms (SNPs) that might improve performance in this population. Anonymized genotypic data were obtained from the PRACTICAL consortium for 6253 men with African genetic ancestry. Ten iterations of a 10‐fold cross‐validation search were conducted to select SNPs that would be included in the final PHS46+African model. The coefficients of PHS46+African were estimated in a Cox proportional hazards framework using age at diagnosis as the dependent variable and PHS46, and selected SNPs as predictors. The performance of PHS46 and PHS46+African was compared using the same cross‐validated approach. Three SNPs (rs76229939, rs74421890 and rs5013678) were selected for inclusion in PHS46+African. All three SNPs are located on chromosome 8q24. PHS46+African showed substantial improvements in all performance metrics measured, including a 75% increase in the relative hazard of those in the upper 20% compared to the bottom 20% (2.47‐4.34) and a 20% reduction in the relative hazard of those in the bottom 20% compared to the middle 40% (0.65‐0.53). In conclusion, we identified three SNPs that substantially improved the association of PHS46 with age at diagnosis of prostate cancer in men with African genetic ancestry to levels comparable to Europeans.
Analysis of distinct asymmetries in financial integration‐growth nexus for industrial, emerging and developing countries
Authors: Yolcu Karadam Duygu , Öcal Nadir 
Published: September 2020

AbstractThis paper examines the threshold conditions in financial integration and growth relationship for a large set of threshold variables and different income group of countries employing Panel Smooth Transition Regression Models. Except developing countries, our findings strongly indicate nonlinear dynamics and imply that the impact of financial integration on growth is asymmetric depending on a number of indicators such as countries' degree of institutional quality, financial sector development, trade openness, budget deficit, inflation volatility and the level of financial integration. Our results show that these threshold effects substantially differ for emerging and industrial countries. As far as whole set of countries is concerned, our findings imply that countries having developed financial systems, qualified institutions and stable macroeconomic environment benefit from financial integration. Moreover, threshold effects are stronger and different for emerging countries compared to the industrial countries. Unlike emerging economies, higher levels of financial integration and trade openness decrease benefits from financial openness for the industrial countries. Besides, high fiscal deficit has more pronounced negative effect on the growth of the industrialized countries compared to emerging economies and other indicators.
DEPTOR Prevents Osteoarthritis Development Via Interplay With TRC8 to Reduce Endoplasmic Reticulum Stress in Chondrocytes
Authors: Li Kai , Yang Panpan , Zhang Yuwei , Zhang Yue , Cao He , Liu Peilin , Huang Bin , Xu Song , Lai Pinglin , Lei Guanghua , Liu Jia , Tang Yujin , Bai Xiaochun , Zou Zhipeng 
Published: September 2020

ABSTRACT
Endoplasmic reticulum (ER) stress has been shown to promote chondrocyte apoptosis and osteoarthritis (OA) progression, but the precise mechanisms via which ER stress is modulated in OA remain unclear. Here we report that DEP domain-containing mTOR-interacting protein (DEPTOR) negatively regulated ER stress and OA development independent of mTOR signaling. DEPTOR is ubiquitinated in articular chondrocytes and its expression is markedly reduced along with OA progression. Deletion of DEPTOR in chondrocytes significantly promoted destabilized medial meniscus (DMM) surgery-induced OA development, whereas intra-articular injection of lentivirus-expressing DEPTOR delayed OA progression in mice. Proteomics analysis revealed that DEPTOR interplayed with TRC8, which promoted TRC8 auto-ubiquitination and degraded by the ubiquitin–proteasome system (UPS) in chondrocytes. Loss of DEPTOR led to TRC8 accumulation and excessive ER stress, with subsequent chondrocyte apoptosis and OA progression. Importantly, an inhibitor of ER stress eliminated chondrocyte DEPTOR deletion-exacerbated OA in mice. Together, these findings establish a novel mechanism essential for OA pathogenesis, where decreasing DEPTOR in chondrocytes during OA progression relieves the auto-ubiquitination of TRC8, resulting in TRC8 accumulation, excessive ER stress, and OA progression. Targeting this pathway has promising therapeutic potential for OA treatment. © 2020 American Society for Bone and Mineral Research (ASBMR).
Health Service Use and Quality of Life Recovery 12 Months Following Major Osteoporotic Fracture: Latent Class Analyses of the International Costs and Utilities Related to Osteoporotic Fractures Study (ICUROS)
Authors: Talevski Jason , Sanders Kerrie M , Busija Ljoudmila , Beauchamp Alison , Duque Gustavo , Borgström Fredrik , Kanis John A , Svedbom Axel , Connaughton Catherine , Stuart Amanda L , Brennan-Olsen Sharon L 
Published: September 2020

Abstract
Major osteoporotic fractures (MOFs) are associated with a rapid decline in health-related quality of life (HRQoL); however, there is limited knowledge about which healthcare services positively affect HRQoL postfracture. This study aimed to identify specific combinations of health service use associated with recovery of HRQoL 12 months post-MOF. The analyses included 4126 adults aged ≥50 years with an MOF (1657 hip, 1354 distal forearm, 681 vertebrae, 434 humerus) participating in the International Costs and Utilities Related to Osteoporotic fractures Study (ICUROS), a multinational observational study (Australia, Austria, Estonia, France, Italy, Lithuania, Mexico, Russia, Spain, United Kingdom, and United States). HRQoL at prefracture and 12 months postfracture was measured using the EuroQoL questionnaire (EQ-5D-3L). Health service use data were collected via participant interviews and medical record reviews including in-hospital care; outpatient care; community services; and medication use. Data analyses involved two stages: (i) latent class analyses to identify different combinations of health service use (“classes”); and (ii) logistic regression to assess effects of classes on HRQoL recovery. Analyses were repeated excluding hip fractures (non-hip MOFs). Overall, 2057 MOF participants (49.9%) recovered to their prefracture HRQoL at 12-month follow-up; this proportion was higher for non-hip MOFs (n = 1439; 58.3%). Several distinct classes were identified across countries (range, 2–5 classes). Classes that were associated with increased odds of HRQoL recovery were characterized by a combination of hospital presentations without admission; outpatient department visits; allied health visits; vitamin D/calcium supplementation; and/or non-opioid analgesic use. Similar classes were observed for non-hip MOFs. Understanding country-specific healthcare service pathways that influence greater recovery of HRQoL, particularly services that are uncommon in some countries and routine in others, could improve postfracture care on a global scale. © 2020 American Society for Bone and Mineral Research (ASBMR).
Differential microRNA expression in the peripheral blood from human patients with COVID‐19
Authors: Li Caixia , Hu Xiao , Li Leilei , Li Jin‐hui 
Published: September 2020

AbstractIntroductionThe coronavirus disease (COVID‐19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), which play important roles in regulating gene expression and are also considered as essential modulators during viral infection. The aim of this study was to elucidate the differential expression of miRNAs in COVID‐19.MethodsThe total RNA was extracted and purified from the peripheral blood of ten patients with COVID‐19 and four healthy donors. The expression levels of various miRNAs were detected by high‐throughput sequencing, and correlation analysis was performed on the target genes that are primed by miRNAs.Key findingsCompared with the healthy controls, 35 miRNAs were upregulated and 38 miRNAs were downregulated in the human patients with COVID‐19. The top 10 genes were listed below: hsa‐miR‐16‐2‐3P,hsa‐miR‐5695,hsa‐miR‐10399‐3P,hsa‐miR‐6501‐5P,hsa‐miR‐361‐3P,hsa‐miR‐361‐3p, hsa‐miR‐4659a‐3p, hsa‐miR‐142‐5p, hsa‐miR‐4685‐3p, hsa‐miR‐454‐5p, and hsa‐miR‐30c‐5p. The 10 genes with the greatest reduction were listed below: hsa‐miR‐183‐5p, hsa‐miR‐627‐5p, hsa‐miR‐941, hsa‐miR‐21‐5p, hsa‐miR‐20a‐5p, hsa‐miR‐146b‐5p, hsa‐miR‐454‐3p, hsa‐miR‐18a‐5p, hsa‐miR‐340‐5p, and hsa‐miR‐17‐5p. Remarkably, miR‐16‐2‐3p was the most upregulated miRNA, with a 1.6‐fold change compared to that of the controls. Moreover, the expression of miR‐6501‐5p and miR‐618 was 1.5‐fold higher in the COVID‐19 patients than in the healthy donors. Meanwhile, miR‐627‐5p was the most downregulated miRNA, with a 2.3‐fold change compared to that of the controls. The expression of other miRNAs (miR‐183‐5p, miR‐627‐5p, and miR‐144‐3p) was reduced by more than 1.3‐fold compared to that of the healthy donors. Cluster analysis revealed that all of the differentially expressed miRNA target genes were clustered by their regulation of cellular components, molecular functions, and biological processes. Importantly, peptidases, protein kinases, and the ubiquitin system were shown to be the highest enrichment categories by enrichment analysis.ConclusionsThe differential miRNA expression found in COVID‐19 patients may regulate the immune responses and viral replication during viral infection.
Is it time to incorporate physics into the Dental Admissions Test?
Authors: Tandon Rahul 
Published: September 2020

AbstractAlthough physics is a pre‐requisite for dental students prior to matriculation it is not tested on the Dental Admissions Test (DAT). The concepts of physics are found throughout the dental profession, and by testing it on the DAT dental students will be better equipped to relate physics to their field and help advance it. The purpose of this paper is to make the argument for why it should be tested, as well as eliminating some of the superfluous topics on the DAT (ecology, environmental sciences, and plant physiology). This paper will focus on a few of concepts already taught in dentistry, and explore how physics principles apply to several of them. We want to emphasize the importance of physics and how testing even the most basic concepts will help prepare students to “think outside the box”. Classical physics, specifically Newtonian Mechanics, has several applications in nearly all areas of dentistry: restorative, orthodontics, prosthodontics, and surgery. The testing of basic formulas studied in the pre‐requisite physics classes will help ease the transition from college to dental school. Modern physics, namely Quantum Mechanics, also plays a significant role in current dental diagnostics and therapeutics. Additionally, with the development of the Integrated National Board Dental Examination (INBDE) as a replacement for the old NBDE part 1 and 2, there are topics tested that specifically focus on physics: Foundational Knowledge Areas 2 and 3. Thus, it is critical that the student dentist be familiar with these concepts. It is important to note that scientific changes occurring in the health sciences almost mandates students be familiar with concepts rooted in physics. It is then proposed that physics be incorporated into the exam, either with the natural sciences or within the quantitative reasoning section, in addition to eliminating topics not relevant to the dental field.