bluuebunny/crossref_metadata_2025_split huggingface dataset:
Faktor Risiko Kelelahan Kerja pada Operator SPBE PT Putra Arba Mandiri
Authors: Politon Fellysca V. M. , Christine Christine 
Published: December 2020

Kelelahan kerja merupakan stress yang banyak dirasakan oleh pekerja dalam bidang pelayanan terhadap manusia lainnya, seperti perawatan kesehatan, pendidikan, kepolisian, keagamaan. Suatu study mengenai kesehatan mental pekerja menemukan bahwa orang-orang yang mengalami perasaan tidak simpatik terhadap kliennya atau konsumen yang dilayaninya kepada rekan kerjanya dapat menciptakan suasana negatif diantara satuan kerja tersebut. Tujuan diketahuinya faktor risiko kelelahan kerja pada operator SPBE PT putra arba mandiri. Jenis penelitian cross-sectional. Populasi dalam penelitian ini adalah seluruh operator SPBE PT Arba Mandiri. Sampel diambil dengan random sampling atau pengambilan sampel secara acak dimana anggota populasi memiliki kesempatan yang sama untuk terpilih menjadi sampel yaitu 34 responden. Hasil penelitian menunjukkan bahwa secara umum kelelahan kerja tinggi sebanyak 1 responden (2,9%). Kesimpulan kelelahan kerja banyak dialami pada umur >40 tahun sebesar 80%, dengan tekanan darah rendah sebanyak 100% dan indeks massa tubuh yang kurang sebesar 50%. Saran bagi perusahaan diharapkan untuk meningkatkan perhatian bagi kesehatan dan keselamatan para pekerja SPBE dengan berupaya agar pekerja dapat bebas dari alcohol dan bahan psikotropika berbahaya lainnya melalui pelaksanaan medical checkup secara rutin, dan para pekerja disarankan untuk berolahraga untuk menjaga stamina, cuti dan liburan diselenggarakan sebaik– baiknya.
Hubungan Konseling dengan Kepatuhan Minum Obat Anti Tuberkulosis Pasien Tuberkulosis di Kabupaten Poso
Authors: Aldina Ni Nyoman , Hermanto Raden Bagus Bambang , Manggasa Dafrosia Darmi 
Published: December 2020

Pendahuluan: Konseling terhadap penderita tuberkulosis merupakan salah satu komponen yang dapat meningkatkan kepatuhan penderita terhadap pengobatan sehingga meningkatkan angka kesembuhan. Tujuan penelitian: untuk mengetahui hubungan antara konseling pada penderita TB dengan kepatuhan minum obat anti tuberkulosis di wilayah Puskesmas Kawua dan Kayamanya Kabupaten Poso. Metode Penelitian: Desain penelitian adalah cross sectional study. Populasi adalah semua penderita tuberkulosis paru di wilayah kerja Puskesmas Kawua dan Kayamanya Kabupaten Poso. Pengambilan sampel dengan cara Purposive sampling dengan jumlah sampel 41 responden. Analisa data menggunakan Fisher ‘s Exact Test pada α < 0,05. Hasil: Hasil penelitian menunjukkan konseling pada penderita tuberkulosis paru baik 80,5%, kurang 19,5%. kepatuhan minum obat yaitu patuh 70,7%, tidak patuh 29,3%. Penderita yang mendapatkan konseling baik yang patuh minum obat 78,8% dan yang tidak patuh minum obat 21,2%. Penderita yang mendapatkan konseling kurang yang patuh minum obat 37,5% dan yang tidak patuh 62,5%. Hasil analisis statistik menunjukkan nilai p=0,034. Kesimpulan: Kesimpulan penelitian ini adalah terdapat hubungan konseling pada penderita tuberkulosis dengan kepatuhan minum obat anti tuberkulosis di wilayah Puskesmas Kawua dan Kayamanya Kabupaten Poso. Saran: Saran bagi pengelola program TB untuk mampu memberikan konseling yang berkualitas bagi penderita tuberkulosis
Mesozoic Paleo-Pacific Subduction Beneath SW Borneo: U-Pb Geochronology of the Schwaner Granitoids and the Pinoh Metamorphic Group
Authors: Breitfeld H. Tim , Davies Lorin , Hall Robert , Armstrong Richard , Forster Marnie , Lister Gordon , Thirlwall Matthew , Grassineau Nathalie , Hennig-Breitfeld Juliane , van Hattum Marco W. A. 
Published: December 2020

The Schwaner Mountains in southwestern Borneo form a large igneous province with a complex magmatic history and poorly known tectonic history. Previously it was known that Cretaceous granitoids intruded metamorphic rocks of the Pinoh Metamorphic Group assumed to be of Paleozoic age. Jurassic granitoids had been reported from the southern Schwaner Mountains. Most ages were based on K-Ar dating. We present new geochemistry, zircon U-Pb and40Ar/39Ar age data from igneous and metamorphic rocks from the Schwaner Mountains to investigate their tectono-magmatic histories. We subdivide the Schwaner Mountains into three different zones which record rifting, subduction-related and post-collisional magmatism. The Northwest Schwaner Zone (NWSZ) is part of the West Borneo Block which in the Triassic was within the Sundaland margin. It records Triassic to Jurassic magmatism during early Paleo-Pacific subduction. In contrast, the North Schwaner Zone (NSZ) and South Schwaner Zone (SSZ) are part of the SW Borneo (Banda) Block that separated from NW Australia in the Jurassic. Jurassic granitoids in the SSZ are within-plate (A-type) granites interpreted to have formed during rifting. The SW Borneo (Banda) Block collided with eastern Sundaland at c. 135 Ma. Following this, large I-type granitoid plutons and arc volcanics formed in the NWSZ and NSZ between c. 90 and 132 Ma, associated with Cretaceous Paleo-Pacific subduction. The largest intrusion is the c. 110 to 120 Ma Sepauk Tonalite. After collision of the East Java-West Sulawesi (Argo) Block, subduction ceased and post-collisional magmatism produced the c. 78 to 85 Ma Sukadana Granite and the A-type 72 Ma Sangiyang Granite in the SSZ. Rocks of the Pinoh Metamorphic Group mainly exposed in the NSZ, previously assumed to represent Paleozoic basement, contain abundant Early Cretaceous (110 to 135 Ma) zircons. They are interpreted as volcaniclastic sediments that formed contemporaneously with subduction-related volcanic rocks of the NSZ subsequently metamorphosed during intrusion of Cretaceous granitoids. There are no igneous rocks older than Cretaceous in the NSZ and older than Jurassic in the SSZ and there is no evidence for a continuation of a Triassic volcanic arc crossing Borneo from Sundaland to the east.
Prevalence of Diabetes and Its Determinants in the Young Adults Indian Population-Call for Yoga Intervention
Authors: Nagarathna Raghuram , Bali Parul , Anand Akshay , Srivastava Vinod , Patil Suchitra , Sharma Guruprasad , Manasa Krishna , Pannu Viraaj , Singh Amit , Nagendra Hongasandra R. 
Published: December 2020

BackgroundThe young Indian population, which constitutes 65% of the country, is fast adapting to a new lifestyle, which was not known earlier. They are at a high risk of the increasing burden of diabetes and associated complications. The new evolving lifestyle is not only affecting people’s health but also mounting the monetary burden on a developing country such as India.AimWe aimed to collect information regarding the prevalence of risk of diabetes in young adults (&lt;35 years) in the 29 most populous states and union territories (7 zones) of India, using a validated questionnaire.MethodsA user-friendly questionnaire-based survey using a mobile application was conducted on all adults in the 29 most populous states/union territories of India, after obtaining ethical clearance for the study. Here, we report the estimation of the prevalence of the risk of diabetes and self-reported diabetes on 58,821 young individuals below the age of 35 years. Risk for diabetes was assessed using a standardized instrument, the Indian diabetes risk score (IDRS), that has 4 factors (age, family history of diabetes, waist circumference, and physical activity). Spearman’s correlation coefficient was used to check the correlations.ResultsThe prevalence of high (IDRS score &gt; 60), moderate (IDRS score 30–50), and low (IDRS &lt; 30) diabetes risk in young adults (&lt;35 years) was 10.2%, 33.1%, and 56.7%, respectively. Those with high-risk scores were highest (14.4%) in the Jammu zone and lowest (4.1%) in the central zone. The prevalence of self-reported diabetes was 1.8% with a small difference between men (1.7%) and women (1.9%), and the highest (8.4%) in those with a parental history of diabetes. The south zone had the highest (2.5%), and the north west zone had the lowest (4.4%) prevalence.ConclusionsIndian youth are at high risk for diabetes, which calls for an urgent action plan through intensive efforts to promote lifestyle behavior modifications during the pandemics of both communicable and noncommunicable diseases.
Cytokines, Adipokines, and Bone Markers at Rest and in Response to Plyometric Exercise in Obese vs Normal Weight Adolescent Females
Authors: Kurgan Nigel , McKee Katherine , Calleja Melissa , Josse Andrea R. , Klentrou Panagiota 
Published: December 2020

BackgroundIn adults, excess adiposity has been associated with low-grade, chronic inflammation and compromised bone health, but less is known about these linkages in children. The purpose of this study was to compare the circulating levels of inflammatory cytokines, adipokines, osteokines, and bone markers at rest and in response to plyometric exercise between obese and normal weight adolescent females.MethodsTen normal weight (BMI = 21.3 ± 2) and 10 obese (BMI = 32.9 ± 4), postmenarcheal females, aged 13–17 years, performed one bout of plyometric exercise (5 circuits; 120 jumps). Blood samples were taken at rest, 5 min, 1 h, and 24 h post-exercise. Tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), insulin, leptin, osteocalcin, carboxy-terminal telopeptide (CTX), sclerostin, and parathyroid hormone (PTH) were measured in serum.ResultsCytokines were not different between groups at rest or over time with IL-6 increasing (+31%; p = 0.04) 5 min post-exercise and TNF-α decreasing (-9%; p = 0.001) 1 h post-exercise. Insulin and leptin were higher in the obese compared to the normal weight females. In both groups, insulin significantly increased 5 min post-exercise but remained elevated 1 h post-exercise only in the obese group. Leptin did not change in response to exercise. Osteocalcin was lower in the obese group across time and increased (+12%; p = 0.02) 24 h post-exercise in both groups. CTX was similar between groups at rest and decreased (-24%; p &lt; 0.001) 1 h post-exercise. Sclerostin was similar between groups at rest, but there was a significant interaction reflecting a significant increase (+29%; p = 0.04) 5 min post-exercise in the obese group and a non-significant decrease (-13%; p = 0.08) in normal weight controls. PTH increased 5 min post-exercise, dropped 1 h post-exercise to lower than pre-exercise, and returned to baseline 24 h post-exercise in both groups.ConclusionObese adolescent females from our study had no evidence of resting inflammation or differences in bone resorption but show blunted bone formation when compared to normal weight controls. The direction and temporal changes in inflammatory cytokines, adipokines, and bone turnover markers to exercise were similar in both groups, reflecting an overall bone anabolic response for most biomarkers, except sclerostin, which increased only in the obese females immediately post-exercise, suggesting a different systemic regulation of sclerostin depending on adiposity.
Icaritin Enhancing Bone Formation Initiated by Sub-Microstructured Calcium Phosphate Ceramic for Critical Size Defect Repair
Authors: Peng Haitao , Li Jianxiao , Xu Yanan , Lv Guoyu 
Published: December 2020

Adequate bone tissue regeneration has been challenging to achieve at critical-sized bone defects caused by disease. Bone tissue engineering using a combination of scaffolds and bioactive factors provides new hope for the treatment of this extreme condition. Icaritin, a herb-derived chemical, has shown its ability to enhance bone formation both in vitro and in vivo, and it has been found that sub-micron surface structure instructs bone formation in calcium phosphate ceramics (CaPs). Here, we evaluated the possibility of using a submicron surface structured CaP ceramic as the carrier of icaritin for bone tissue regeneration in critical-sized bone defects. Icaritin, an herb-derived chemical, was loaded into a submicron surface structured porous calcium phosphate ceramic (Ø12.8 × 3 mm) to get samples with 0, 10, 50, 250, and 1,250 µg icaritin per CaP disc (M0, M10, M50, M250, M1250 groups, respectively). In vitro evaluation with the certain dosages correlated to those released from the samples showed a dose-dependent enhancement of osteogenic differentiation and mineralization of human bone marrow stromal cells with the presence of osteogenic factors in the culture medium, indicating icaritin is an osteopromotive factor. After intramuscular implantation of the samples in dogs for 8 weeks, a dose-dependent of bone formation was seen with enhanced bone formation at the dosage of 50 and 250 µg. To evaluate the in vivo osteogenic potentials of icaritin-containing CaP ceramic scaffolds in the orthopedic site, a 12.8 mm calvarial defect model in rabbits was established. Micro-computed tomography (micro-CT) and histology results at weeks 4, 8 and 12 post-surgery showed more newly formed bone in M250 group, with correspondingly more new vessel ingrowth. The results presented herein suggested that being osteopromotive, icaritin could enhance bone formation initiated by sub-microstructured CaP ceramics and the CaP ceramics scaffold incorporating icaritin is a promising biomaterial for the treatment of critical-sized defect.
Increased Red Cell Distribution Width Is Associated With Disease Severity in Hospitalized Adults With SARS-CoV-2 Infection: An Observational Multicentric Study
Authors: Karampitsakos Theodoros , Akinosoglou Karolina , Papaioannou Ourania , Panou Vassiliki , Koromilias Athanasios , Bakakos Petros , Loukides Stelios , Bouros Demosthenes , Gogos Charalampos , Tzouvelekis Argyrios 
Published: December 2020

Background: There is an amenable need for clinically applicable biomarkers in patients with SARS-CoV-2 infection. Red Cell Distribution Width (RDW) has been recently suggested as a prognostic biomarker for COVID-19.Methods: This was an observational study enrolling patients between February 26 and May 15 2020. We aimed to validate the association of the previously published RDW threshold of 14.5% with markers of disease progression and mortality.Results: A total number of 193 hospitalized patients with COVID-19 were enrolled and analyzed. Median age was 61 years (95% CI: 58–64). Patients with baseline RDW ≥14.5% (n = 41, 19.2%) presented with more progressive disease compared to patients with baseline RDW &lt;14.5% (n = 156, 80.8%) as indicated by significant differences in maximum FiO2% during hospitalization (median: 100, 95% CI: 45.2–100, vs. 35, 95% CI: 31–40, p = 0.0001, respectively). Values of RDW ≥14.5% were also strongly associated with increased risk of mortality (HR: 4.1, 95% CI: 0.88–19.23), (p = 0.02).Conclusion: Our study provides evidence to support reproducibility and validity of a specified cut-off threshold of RDW as biomarker of disease severity and mortality in patients with COVID-19.
Effect of Bone Marrow Stromal Cells in Parkinson's Disease Rodent Model: A Meta-Analysis
Authors: Liu Jianyang , He Jialin , Huang Yan , Hu Zhiping 
Published: December 2020

Background: Bone marrow stromal cells (BMSCs) has been reported to have beneficial effects in improving behavioral deficits, and rescuing dopaminergic neuron loss in rodent models of Parkinson's disease (PD). However, their pooled effects for dopaminergic neuron have yet to be described.Objective: To review the neuroprotective effect of naïve BMSCs in rodent models of PD.Methods: The PubMed, EMBASE, and Web of Science databases were searched up to September 30, 2020. Inclusion criteria according to PICOS criteria were as follows: (1) population: rodents; (2) intervention: unmodified BMSCs; (3) comparison: not specified; (4) primary outcome: tyrosine hydroxylase level in the substantia nigra pars compacta and rotational behavior; secondary outcome: rotarod test, and limb function; (5) study: experimental studies. Multiple prespecified subgroup and meta-regression analysis were conducted. Following quality assessment, random effects models were used for this meta-analysis.Results: Twenty-seven animal studies were included. The median quality score was 4.7 (interquartile range, 2–8). Overall standardized mean difference between animals treated with naïve BMSCs and controls was 2.79 (95% confidence interval: 1.70, 3.87; P &lt; 0.001) for densitometry of tyrosine hydroxylase-positive staining; −1.54 (95% confidence interval: −2.11, −0.98; P &lt; 0.001) for rotational behavior. Significant heterogeneity among studies was observed.Conclusions: Results of this meta-analysis suggest that naïve BMSCs therapy increased dopaminergic neurons and ameliorated behavioral deficits in rodent models of PD.
Prognostic Value of Preoperative Hydronephrosis in Patients Undergoing Radical Nephroureterectomy for Upper Tract Urinary Carcinoma: A Systematic Review and Meta-Analysis
Authors: Ye Tao , Yang Xiaoqi , Lv Peng , Liu Haoran , Ye Zhangqun 
Published: December 2020

BackgroundSeveral recent publications have evaluated the prognostic value of preoperative hydronephrosis (HN) in patients with upper tract urinary carcinoma (UTUC). The aim of this meta-analysis was to explore the pooled effect of preoperative HN on the prognosis of UTUC patients treated with radical nephroureterectomy (RNU) based on current evidence.MethodsWe performed a systematic search of Pubmed, Cochrane library, and Web of Science databases from inception to June 2020. The outcomes of interest included overall survival (OS), cancer-special survival (CSS), disease-free survival (DFS), and intravesical recurrence-free survival (IVRFS).ResultsTwenty-two studies with a total of 7,542 patients satisfied the eligibility criteria and were finally included in this meta-analysis. The percent of patients with preoperative HN varied in the eligible studies, ranging from 18 to 81%. The pooled results showed that preoperative HN was significantly associated with worse OS (P = 0.004), CSS (P &lt; 0.001), and DFS (P = 0.005), but not IVRFS (P = 0.12). No obvious publication bias was detected by Begg’s test in all the analyses.ConclusionsThe results drawn in our meta-analysis suggest that the presence of preoperative HN is associated with worse prognosis in patients treated with RNU for UTUC. Therefore, closer surveillance and more aggressive therapy may be needed for UTUC patients present with preoperative HN. Well-designed prospective studies are necessary to substantiate the prognostic value of HN in UTUC.
Bortezomib-Based Regimens for Newly Diagnosed Multiple Myeloma in China: A Report of 12-Year Real-World Data
Authors: He Jingsong , He Donghua , Han Xiaoyan , Zheng Gaofeng , Wei Guoqing , Zhao Yi , Yang Yang , Wu Wenjun , Fu Jiaping , Shou Lihong , Kong Hongwei , Huang He , Cai Zhen 
Published: December 2020

Background: Improve the treatment quality might affect patients’ efficacy and survival.Methods: Five hundred thirty multiple myeloma patients treated in four hematological centers in China from February 2006 to August 2018 were enrolled. General characteristics, treatment regimens and cycles, efficacy, survival and adverse events of the patients treated before and after August 2013 (later refer to as the before-2013 and after-2013 group) were analyzed and compared.Results: The results suggested that patients who received optimized treatment regimen and route of administration completed more cycles of treatment in the after-2013 group. Although the overall response rate was similar between the two groups (88.6 vs. 90.5%), patients in the after-2013 group had higher complete remission rate (39.1 vs. 28.6%) and better progression-free survival. Subgroup analysis suggested that patients aged 65 years and older, with non-high-risk D-S, ISS, and R-ISS stages, had a significant benefit in progression-free survival.Conclusion: Therefore, in clinical practice in China, by reducing the economic burden brought by the treatment on patients and optimizing the treatment regimen, more patients can be treated with better regimens in a prolonged duration to achieve better efficacy and survival, especially in elderly and non-high-risk patients.
Inhibition of p38 MAPK Mitigates Lung Ischemia Reperfusion Injury by Reducing Blood–Air Barrier Hyperpermeability
Authors: Wang Tiantian , Liu Chunxia , Pan Ling-hui , Liu Zhen , Li Chang-long , Lin Jin-yuan , He Yi , Xiao Jing-yuan , Wu Siyi , Qin Yi , Li Zhao , Lin Fei 
Published: December 2020

Background: Lung ischemia reperfusion injury (LIRI) is a complex pathophysiological process activated by lung transplantation and acute lung injury. The p38 mitogen-activated protein kinase (MAPK) is involved in breakdown of the endothelial barrier during LIRI, but the mechanism is still unclear. Therefore, we investigated the function of p38 MAPK in LIRI in vivo and in vitro.Methods: Sprague–Dawley rats were subjected to ischemia reperfusion with or without pretreatment with a p38 MAPK inhibitor. Lung injury was assessed using hematoxylin and eosin staining, and pulmonary blood–air barrier permeability was evaluated using Evans blue staining. A rat pulmonary microvascular endothelial cell line was infected with lentiviral expressing short hairpin (sh)RNA targeting p38 MAPK and then cells were subjected to oxygen/glucose deprivation and reoxygenation (OGD/R). Markers of endothelial destruction were measured by western blot and immunofluorescence.Results:In vivo LIRI models showed structural changes indicative of lung injury and hyperpermeability of the blood–air barrier. Inhibiting p38 MAPK mitigated these effects. Oxygen/glucose deprivation and reoxygenation promoted hyperpermeability of the endothelial barrier in vitro, but knockdown of p38 MAPK attenuated cell injury; maintained endothelial barrier integrity; and partially reversed injury-induced downregulation of permeability protein AQP1, endothelial protective protein eNOS, and junction proteins ZO-1 and VE-cadherin while downregulating ICAM-1, a protein involved in destroying the endothelial barrier, and ET-1, a protein involved in endothelial dysfunction.Conclusion: Inhibition of p38 MAPK alleviates LIRI by decreasing blood–air hyperpermeability. Blocking p38 MAPK may be an effective treatment against acute lung injury.
Burnout Syndrome Among Hospital Healthcare Workers During the COVID-19 Pandemic and Civil War: A Cross-Sectional Study
Authors: Elhadi Muhammed , Msherghi Ahmed , Elgzairi Moutaz , Alhashimi Ayiman , Bouhuwaish Ahmad , Biala Marwa , Abuelmeda Seraj , Khel Samer , Khaled Ala , Alsoufi Ahmed , Elmabrouk Amna , Alshiteewi Fatimah Bin , Hamed Tasneem Ben , Alhadi Bushray , Alhaddad Sara , Elhadi Ahmed , Zaid Ahmed 
Published: December 2020

Objective: We aimed to determine the prevalence of burnout among hospital healthcare workers in Libya during the coronavirus disease (COVID-19) pandemic and civil war.Methods: A cross-sectional study was conducted from April 18 to May 2, 2020 among Libyan healthcare workers. Data on participant characteristics were collected with a specifically designed questionnaire. Burnout was assessed with the abbreviated Maslach Burnout Inventory (aMBI) comprising three subscales: emotional exhaustion (EE), depersonalization (DP), and personal accomplishment (PA), with each sub-scale score range from 0 to 18. For EE and DP, scores of 10 to 18 were regarded as “moderate to severe burnout.” PA was scored inversely, where a score ≤ 10 indicated severe burnout.Results: The study yielded a sample size of 532 participants. Of these, 357 (67.1%) reported emotional exhaustion (EE Score ≥ 10), 252 (47.4%) reported depersonalization (DP score ≥ 10), and 121 (22.7%) reported a lower sense of personal accomplishment (PA score ≤ 10). Verbal abuse was experienced by 304 participants (57.1%) and physical abuse in 93 (17.5). Gender was associated with high emotional exhaustion and high depersonalization. Being 35 years or older was associated with high depersonalization. Professional specialty was significantly associated with high emotional exhaustion and depersonalization. Fear of COVID-19 infection was associated with high emotional exhaustion and high depersonalization.Conclusion: The rising prevalence of mental disorders and inadequate availability of health services facilities during the COVID-19 pandemic and civil war demonstrated the need for healthcare policies to address the well-being of healthcare workers to decrease the risk of loss, suicide, and medical negligence.