bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiovascular problems associated with IVF therapy
Authors: Henriksson P. 
Published: June 2020

AbstractWe are now in the beginning of the fifth decade of in vitro fertilization (IVF) with more than ten million children born and an annual growth rate of half a million. It was recently found that there is a sevenfold increase in the incidence of pulmonary embolism (PE) during the first trimester of an IVF pregnancy as compared to spontaneous pregnancy. PE is a major cause of maternal mortality, and it is thus of outmost importance to understand the pathophysiological mechanism. The oestrogen surge during the ovarian stimulation has been hypothesized to be the initiating pathophysiological event. A support of this is a current report showing that embryo transfer performed directly after ovarian stimulation increased the risk of PE more than eightfold, whereas no such increase was noted after delayed embryo transfer. This increased risk coincides with a persisting increased oestrogen level. Further reported cardiovascular problems are arterial thromboses, pre‐eclampsia and gestational hypertension. Global haemostasis tests change in the direction of increased coagulability, but mostly within normal limits. Cell‐bound haemostasis and in particular platelet activation are less studied. However, a major increase in the number of microvesicles (MVs) and markers indicating platelet activation was reported during ovarian stimulation. We now need longitudinal data concerning haemostatic variables that extends into the first trimester. A major research focus should be to identify biomarkers that could be used already before instigation of IVF. Another way to avoid risk could be to delay embryo transfer by adapting a freeze‐all strategy.
Stroke Treatment Delay Limits Outcome After Mechanical Thrombectomy: Stratification by Arrival Time and ASPECTS
Authors: Snyder Thomas , Agarwal Shashank , Huang Jeffrey , Ishida Koto , Flusty Brent , Frontera Jennifer , Lord Aaron , Torres Jose , Zhang Cen , Rostanski Sara , Favate Albert , Lillemoe Kaitlyn , Sanger Matthew , Kim Sun , Humbert Kelley , Scher Erica , Dehkharghani Seena , Raz Eytan , Shapiro Maksim , K Nelson Peter , Gordon David , Tanweer Omar , Nossek Erez , Farkas Jeffrey , Liff Jeremy , Turkel‐Parrella David , Tiwari Ambooj , Riina Howard , Yaghi Shadi 
Published: June 2020

ABSTRACTBACKGROUND AND PURPOSEMechanical thrombectomy (MT) has helped many patients achieve functional independence. The effect of time‐to‐treatment based in specific epochs and as related to Alberta Stroke Program Early CT Score (ASPECTS) has not been established. The goal of the study was to evaluate the association between last known normal (LKN)‐to‐puncture time and good functional outcome.METHODSWe conducted a retrospective cohort study of prospectively collected acute ischemic stroke patients undergoing MT for large vessel occlusion. We used binary logistic regression models adjusted for age, Modified Treatment in Cerebral Ischemia score, initial National Institutes of Health Stroke Scale, and noncontrast CT ASPECTS to assess the association between LKN‐to‐puncture time and favorable outcome defined as Modified Rankin Score 0‐2 on discharge.RESULTSAmong 421 patients, 328 were included in analysis. Increased LKN‐to‐puncture time was associated with decreased probability of good functional outcome (adjusted odds ratio [aOR] ratio per 15‐minute delay = .98; 95% confidence interval [CI], .97‐.99; P = .001). This was especially true when LKN‐puncture time was 0‐6 hours (aOR per 15‐minute delay = .94; 95% CI, .89‐.99; P = .05) or ASPECTS 8‐10 (aOR = .98; 95% CI, .97‐.99; P = .002) as opposed to when LKN‐puncture time was 6‐24 hours (aOR per 15‐minute delay = .99; 95% CI, .97‐1.00; P = .16) and ASPECTS <8 (aOR = .98; 95% CI, .93‐1.03; P = .37).CONCLUSIONDecreased LKN‐groin puncture time improves outcome particularly in those with good ASPECTS presenting within 6 hours. Strategies to decrease reperfusion times should be investigated, particularly in those in the early time window and with good ASPECTS.
COVID‐19 Screening with Chest CT in Acute Stroke Imaging: A Clinical Decision Model
Authors: Qureshi Adnan I. , French Brandi R. , Siddiq Farhan , Arora Niraj A. , Nattanmai Premkumar , Gomez Camilo R. 
Published: June 2020

ABSTRACTBACKGROUND AND PURPOSEAcute stroke patients may have undiagnosed coronavirus disease 2019 (COVID‐19) infection, transmissible to medical professionals involved in their care. Our aim was to determine the value of incorporating a chest computed tomography (CT) scan during acute stroke imaging, and the factors that influence this decision.METHODSWe constructed a probabilistic decision tree of the value of acquiring a chest CT scan or not, expressed in quality‐adjusted life months (QALM) of patients and medical professionals. The model was based on the chance of detecting infection by chest CT scan, the case fatality rates of COVID‐19 infection, the risk of COVID‐19 infection after exposure, the expected proportion of medical professionals exposed, and the exposure reduction derived from early disease detection.RESULTSThe decision to incorporate the chest CT scan was superior to not doing so (12.00 QALM vs 11.99 QALM, respectively), when the probability of patients having undetected COVID‐19 infection is 3.5%, potentially exposing 100% of medical professionals, and if early detection reduces exposure by 50%. The risk of developing symptomatic COVID‐19 infection following exposure casts uncertainty on the results, but this is offset by the potential for reducing exposure.CONCLUSIONSWe identified a measurable benefit of incorporating a chest CT into the urgent imaging protocol of acute stroke patients in reducing exposure of medical professionals without appropriate precautions. The clinical impact of this benefit, however, may not be materially significant.
Vagus Nerve Ultrasound in Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Charcot‐Marie‐Tooth Disease Type 1A
Authors: Niu Jingwen , Zhang Lei , Ding Qingyun , Liu Jingwen , Zhang Zhe , Cui Liying , Liu Mingsheng 
Published: June 2020

ABSTRACTBACKGROUND AND PURPOSEBoth clinical autonomic dysfunction and involvement of autonomic nerves have been reported in a range of peripheral nerve disorders. We employed nerve ultrasound to assess the size of the vagus nerve in a serial study of patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and Charcot‐Marie‐Tooth type 1B (CMT1B) as compared to healthy controls (HCs). We correlated these findings with involvement of the median and ulnar nerves.METHODSForty‐three patients with CIDP, 8 with CMT1A, and 105 HC were prospectively recruited. The cross‐sectional areas (CSAs) of the vagus, median, and ulnar nerves were measured bilaterally. The alteration of CSA of those nerves was followed longitudinally in CIDP.RESULTSThe median (range) CSA of the vagus nerve was 2 (1‐28) mm2 in CIDP, 3 (2‐6) mm2 in CMT1A, and 1 (1‐2) mm2 in HC. The vagus nerve CSA was positively correlated with the maximum CSA of median/ulnar nerve in CIDP and CMT1A. The alteration in vagus nerve CSA was positively correlated with the alteration in mean median/ulnar nerve CSA in CIDP during follow‐up.CONCLUSIONSThe vagus nerve was involved to a similar extent as the median and ulnar nerves in CIDP and CMT1A, although no symptoms or signs of vagus nerve involvement were found. Further study should be performed to explore the clinical relevance of vagus nerve enlargement in these disorders.
Management of burning mouth Syndrome: A position paper of the Chinese Society of Oral Medicine
Authors: Chen Qianming , Shi Yujie , Jiang Lu , Zhou Yu , Dan Hongxia , Jin Xin , Sun Silu , Zeng Xin 
Published: June 2020

AbstractBackgroundBurning mouth syndrome is a syndrome with tongue as the main affected site and burning pain as the main complaint. Although a variety of therapies have been reported to treat BMS, there is a lack of widely recognized therapies and it is still a dilemma for clinicians to treat BMS.ObjectiveTo develop the position paper and provide the references for clinical practice of BMS in China.MethodsUnder the guidance of WHO (World Health Organization) Handbook for Guideline Development, we used the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach as a tool to develop this position paper in the following steps: setting up the groups, formulating the clinical questions and choosing the outcomes, retrieving and synthesizing of evidence, assessing the evidence, investigating the patients' values and preferences, developing the recommendations, reviewing the recommendations, and writing the position paper.ResultsThe 27 recommendations were formed from the following 7 aspects: pre‐treatment examination, removal of stimuli, medication, physical therapy, psychological therapy, and antipsychotics. There are 3 strong recommendations and 12 weak recommendations in pre‐treatment examination and removal of stimuli, as well as 12 weak recommendations in therapies.ConclusionThe Chinese position paper for management of BMS has been developed, which could provide the references for clinical practice of BMS in China. Twenty‐seven recommendations were formed based on consensus of experts on the balance of benefits vs side effects, evidence, cost, and patients’ values and preferences, although the quality of evidence is relatively low.
Weak evidence for the management of medication‐related osteonecrosis of the jaw: An overview of systematic reviews and meta‐analyses
Authors: Moraschini Vittorio , Calasans‐Maia Monica Diuana , Louro Rafael Seabra , Arantes Eugênio Braz Rodrigues , Calasans‐Maia José de Albuquerque 
Published: June 2020

AbstractBackgroundAlthough several therapies are proposed for medication‐related osteonecrosis of the jaw (MRONJ), to date there is no consensus or treatment protocol for MRONJ. This overview aims to summarize the available evidence on the management and outcomes of MRONJ.MethodsAn electronic search without language or date restrictions occurred in five databases and gray literature for articles published until March 2020. This overview was performed according to the PICO format. The eligibility criteria comprised systematic reviews (RS) with or without meta‐analyses that analyzed treatments outcomes for MRONJ. The methodological quality of each SR was evaluated using AMSTAR 2.ResultsFifteen studies published between 2014 and 2020 were included in this overview. The summary of the evidence showed that conservative treatment and low level laser therapy can yield favorable results for early stages of MRONJ whereas surgical treatment seems to be better for advanced stages. However, qualitative assessment of the SRs highlighted a global low level of quality.ConclusionsThere is weak evidence to support treatment protocols for MRONJ. Because of the low quality of the SRs, highlighted by this overview, no insightful therapeutic recommendations can be issued for any intervention for MRONJ.
Developmental changes in physiological amino acids and hepatic methionine remethylation enzyme activities in E10‐21 chick embryos and D1‐49 broilers
Authors: Lu Jianwei , Weil Jordan , Cerrate Sandro , Coon Craig 
Published: June 2020

AbstractThe remethylation of homocysteine to methionine is important for chick embryos to sustain the S‐adenosylmethionine transmethylation reactions, which are essential for the rapid proliferation of cells. Developmental changes in hepatic 5‐methyltetrahydrofolate‐homocysteine methyltransferase (MFMT), betaine‐homocysteine methyltransferase (BHMT) and hepatic serine hydroxymethyltransferase (SHMT) were determined in E10‐21 Cobb 500 broiler chick embryos and hatched chicks from D1‐49. Hepatic levels of free serine, glycine, putrescine, spermidine and spermine levels were also determined. Analyses showed hepatic MFMT‐specific activity doubled from E10 to E12, with remaining embryo development experiencing small fluctuations in activity through E21. Hepatic MFMT doubled immediately after hatch, with peak activity occurring at D3. Afterwards, hepatic MFMT‐specific activity steadily declined from D7‐49. Hepatic BHMT activity was higher from E10 to E16 of embryogenesis, decreased rapidly at E17 and remained lower through E21 (p < .05). Hepatic BHMT‐specific activity was also lower in chicks, with the exception of a peak in specific activity on D7. BHMT activity returned to lower levels by D21. Throughout embryogenesis, hepatic SHMT activity in chick embryos remained relatively constant except for a decrease at 13E, followed by an increase at 14E. Maximal activity of SHMT was found the first day post‐hatch. Additionally, SHMT activity was significantly lower in growing chicks than that in embryos. Hepatic‐free serine and glycine levels were negatively correlated with SHMT in hatched chicks. Hepatic polyamine, putrescine and spermidine shared a similar development pattern: peak level in the middle of incubation, low at late embryogenesis and lowest during the post‐hatch period except an increase within one week after hatch. The sharp increase in hepatic concentrations of glycine, serine and putrescine, along with increased specific activities of MHMT, BHMT and SHMT from D1‐7, suggests that methionine conservation (remethylation from homocysteine) and glycine/serine is critical for young chicks for organ growth, maturation, and development.
Influence of the effective microorganisms (EM) on performance, intestinal morphology and gene expression in the jejunal mucosa of pigs fed different diets
Authors: Reszka Patrycja , Dunislawska Aleksandra , Slawinska Anna , Siwek Maria , Kapelański Wojciech , Bogucka Joanna 
Published: June 2020

AbstractThe aim of the study was to determine the influence of the effective microorganisms (EM) on performance parameters, intestinal morphology and gene expression in the jejunal mucosa in pigs under different feeding regimes. The study group comprised of 150 piglets divided into three feeding groups: C, E1 and E2. Feeding groups included: C—standard fodder, blend with a full share of post‐extracted soy meal, E1—in the phase I of fattening: pea and lupin/soybean 50/50%; in the phase II of fattening: pea and lupin/soybean 75/25%, and E2—in the phase I of fattening: pea and lupin/soybean 50/50%; in the phase II of fattening: pea and lupin 100%. The experimental factor was addition of a probiotic EM Carbon Bokashi to the diets (C + EM, E1 + EM and E2 + EM). After slaughter, histological evaluation and gene expression analysis were performed. The highest intestinal villi were reported in E2 + EM. A higher intestinal absorption area was demonstrated in groups C + EM and E2 + EM. An interaction between feeding and EM Bokashi supplementation was found in villus surface area crypt depth, villus height/crypt depth and number of goblet cells. Mucosa thickness and number of goblet cells was the largest in E2 + EM. Gene expression of FABP4 increased in E1, and GLUT2 decreased in E2. Gene expression of IL10 and FABP4 increased in E2 + EM. The results indicate that the E2 diet is more optimal for EM Bokashi supplementation, because in this group, EM positively influenced the morphological characteristics of the porcine jejunum and caused an increase in the expression of genes related to the metabolism and functioning of the gastrointestinal tract.
Cognitive behavioural therapy for insomnia does not appear to have a substantial impact on early markers of cardiovascular disease: A preliminary randomized controlled trial
Authors: Johann Anna Friederike , Hertenstein Elisabeth , Feige Bernd , Akram Umair , Holub Florian , Baglioni Chiara , Domschke Katharina , Schramm Elisabeth , Nissen Christoph , Kyle Simon D. , Riemann Dieter , Biermann Jürgen , Spiegelhalder Kai 
Published: June 2020

AbstractAccording to the World Health Organization, cardiovascular diseases are the leading cause of death in the world. Therefore, early prevention of these diseases is a public health priority. Epidemiological data suggest that insomnia may be a modifiable risk factor for cardiovascular diseases. A randomized controlled trial in a sample of insomnia patients without cardiovascular disease was conducted to investigate the effects of insomnia treatment on early markers of cardiovascular diseases assessed by 24‐hr ambulatory blood pressure, heart rate and heart rate variability monitoring, and morning fasting blood samples. Forty‐six patients with insomnia disorder were randomized to cognitive behavioural therapy for insomnia (CBT‐I; n = 23) or a waitlist control condition (n = 23). Contrary to the hypothesis, intention‐to‐treat analyses did not show any significant treatment effects on early markers of cardiovascular disease (d = 0.0–0.6) despite successful insomnia treatment (d = 1.3). Potential methodological and conceptual reasons for these negative findings are discussed. Future studies might include larger sample sizes that are at risk of cardiovascular diseases and focus on other cardiovascular markers.
Deep sequencing of liver explant transcriptomes reveals extensive expression from integrated hepatitis B virus DNA
Authors: Ringlander Johan , Skoglund Catarina , Prakash Kasthuri , Andersson Maria E. , Larsson Simon B. , Tang Ka‐Wei , Rydell Gustaf E. , Abrahamsson Sanna , Castedal Maria , Norder Heléne , Hellstrand Kristoffer , Lindh Magnus 
Published: June 2020

AbstractHepatitis B virus (HBV) is a major cause of hepatocellular carcinoma (HCC). Integration of HBV DNA into the human genome may contribute to oncogenesis and to the production of the hepatitis B surface antigen (HBsAg). Whether integrations contribute to HBsAg levels in the blood is poorly known. Here, we characterize the HBV RNA profile of HBV integrations in liver tissue in patients with chronic HBV infection, with or without concurrent hepatitis D infection, by transcriptome deep sequencing. Transcriptomes were determined in liver tissue by deep sequencing providing 200 million reads per sample. Integration points were identified using a bioinformatic pipeline. Explanted liver tissue from five patients with end‐stage liver disease caused by HBV or HBV/HDV was studied along with publicly available transcriptomes from 21 patients. Almost all HBV RNA profiles were devoid of reads in the core and the 3′ redundancy (nt 1830‐1927) regions, and contained a large number of chimeric viral/human reads. Hence, HBV transcripts from integrated HBV DNA rather than from covalently closed circular HBV DNA (cccDNA) predominated in late‐stage HBV infection, in particular in cases with hepatitis D virus co‐infection. The findings support the suggestion that integrated HBV DNA can be a significant source of HBsAg in humans.
Hyperintensive stocking densities for Litopenaeus vannamei grow‐out in biofloc technology culture system
Authors: da Silveira Lucas Genesio P. , Krummenauer Dariano , Poersch Luís H. , Rosas Victor Torres , Wasielesky Wilson 
Published: June 2020

AbstractSearching for potential increases in shrimp yields, this study evaluated the effects of different stocking densities on water quality and production performance of juvenile shrimp, Litopenaeus vannamei, reared on a biofloc‐dominated system throughout 77 days. The organisms (1.27 ± 0.54 g) were stocked at three densities, 400 (T400), 500 (T500), and 600 (T600) shrimp/m2 corresponding to 500, 625, and 750 shrimp/m3, with three replicates each, in nine 35 m2 tanks with 28 m3 of workable volume inside a greenhouse. Shrimp were maintained at optimal conditions for the species with an average temperature of 28.9 ± 0.1°C, dissolved oxygen average above 6.0 mg/L, and pH above 7.3. Significant differences in yields (3.52 ± 0.05, 4.02 ± 0.06 and 4.22 ± 0.40 kg/m2 or 4.39 ± 0.07, 4.48 ± 0.08, and 5.27 ± 0.49 kg/m3) were observed between treatments (T400, T500, and T600, respectively), and for final mean weights (12.3 ± 5.53, 12.2 ± 3.89, and 10.2 ± 3.49 g, respectively). These results suggest that 500 shrimp/m2 or 625 shrimp/m3 is the optimum stocking density for Biofloc Technology culture under the defined study conditions.
Use Data‐based Individualization to Improve High School Students’ Mathematics Computation and Mathematics Concept, and Application Performance
Authors: Dennis Minyi Shih , Gratton‐Fisher Emma 
Published: June 2020

AbstractSecondary students with persistent mathematics difficulties need the most intensive intervention in order to improve their mathematics outcomes. One approach to intensifying and individualizing intervention is through data‐based individualization (DBI). The present study used a single‐subject, multiple‐baseline‐across‐participants, replicated‐across‐skills design to investigate the effectiveness of DBI process on mathematics computation and mathematics concept and application performance of high school students who had intense needs in mathematics. Results suggest the interventions guided by the DBI process improved mathematics computation and mathematics concept and application performance of the participants. Implications of these findings and indications for future research are discussed.
Noncontact cable force estimation with unmanned aerial vehicle and computer vision
Authors: Tian Yongding , Zhang Cheng , Jiang Shang , Zhang Jian , Duan Wenhui 
Published: June 2020

AbstractCables and hangers are critical components of long‐span bridges, tension forces of them are needed to be accurately measured for ensuring the safety of bridges. Traditionally, cable tension forces are measured by attached accelerometers or elastomagnetic (EM) sensors, however, applying these sensors into engineering practice are time‐consuming, labor‐intensive, and highly dangerous. To address these problems, an unmanned aerial vehicle (UAV)‐based noncontact cable force estimation method with computer vision technologies was proposed in this article. Basic concept of the proposed method is to use the UAV‐installed camera for capturing vibration images of cables from a certain distance and cable dynamic properties are extracted by analyzing captured images. It includes two aspects: (a) a line segments detector (LSD) was employed for detecting cable edges from captured video and a line matching algorithm was further proposed for extracting dynamic displacements; (b) the frequency difference of adjacent higher modal frequencies identified from relative displacements of the cable was employed for cable force calculation to avoid the difficulty of extracting fundamental frequency from UAV‐captured video. It should be noted that relative displacement herein refers to the difference between displacements of two points on the same cable. Advantages of the proposed method lie in that the proposed LSD and matching algorithm are more robust than traditional correlation‐based algorithm for calculating dynamic displacements of bridge cables and it does not need to adjust predefined parameters (i.e., subset size in correlation‐based algorithms). In addition, the combination of relative displacement and frequency difference‐based cable force estimation has the capability of enhancing the Fourier spectrum magnitude of bridge cables and reducing the effect of UAV motion on extraction of cable vibration frequencies. The effectiveness and robustness of the proposed method was verified by using an experimental inclined cable and field‐testing data of a long‐span suspension bridge. Results show that calculated cable forces with UAV technology have a good agreement with reference values measured by attached accelerometers and fixed camera, demonstrating correctness and robustness of the proposed method for cable force estimation.