bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pemberdayaan Santri Dalam Pengembangan Ekonomi Kreatif “Kimi Bag” Di Pondok Pesantren Al Qohar Klaten
Authors: Wijaya Ning Karna , Aini Soraya 
Published: August 2020

<p><em>The empowerment of santri is a positive effort in realizing the goals of Islamic boarding schools in equipping students with religious knowledge and general science. This study aims to describe and to analyze the empowerment of santri in the Al Qohar Islamic Boarding School Klaten trough the development of creative economic products “Kimi Bag” as an effort to strengthen the soul of santri entrepreneurship. Santri can improve creativity and innovative abilities in developing creative economic ventures. Education and training is carried out by involving santri especially in production activities. The development of “Kimi Bag” products which are able to penetrate foreign markets provide added value for the santri in building motivation and enthusiasm for santri entrepreneurship. This santri empowerment program is expected to be able to instill a spirit of entrepreneurship that is not only worldly profit oriented but also based on the ukhrowi value. </em></p><p><em> </em></p><p><em>Pemberdayaan santri merupakan upaya positif mewujudkan tujuan pondok pesantren membekali santri dengan ilmu keagamaan dan ilmu pengetahuan umum. Penelitian ini bertujuan mendeskripsikan dan menganalisis pemberdayaan santri di Pondok Pesantren Al Qohar Klaten melalui pengembangan usaha ekonomi kreatif “Kimi Bag” sebagai upaya menguatkan jiwa entrepreneurship santri. Santri dapat menyalurkan kemampuan kreasi dan inovasi dalam mengembangkan usaha ekonomi kreatif. Pendidikan dan pelatihan dilakukan dengan melibatkan santri terutama dalam kegiatan produksi. Perkembangan produk “Kimi Bag” yang mampu menembus pasar luar negeri memberi nilai tambah tersendiri bagi para santri dalam membangun motivasi dan semangat entrepreneurship santri. Program pemberdayaan santri ini diharapkan mampu menanamkan jiwa entrepreneurship yang tidak hanya berorientasi keuntungan duniawi saja namun juga dilandasi nilai-nilai ukhrowi. <strong></strong></em></p>
Pendampingan Bagi Guru Madrasah Aliyah Dalam Proses Penyusunan Soal Berbasis Daring Dengan Aplikasi Quizziz
Authors: Tauhidah Dian , Prayitno Muhammad Agus 
Published: August 2020

<p class="ABSTRACT"><em>The era of the industrial revolution 4.0 is an era where human life is always associated with technology and information. One example of activities related to technology and information in madrasah is e-learning. E-learning can improve learning outcomes, critical thinking skills, and motivation. E-learning applications have been found on the internet, including Schoology, Edmodo, Google Classroom, Rumah Belajar, Phet Colorado, Quizziz, and others. Quizziz is an application that supports the organization of test online. The use of the application in daily tests can help teachers reduce errors in assessment. The Quizzez application is also effectively used in class because it is simpler in its application.</em></p><p class="ABSTRACT"> </p><p class="KEYWORD"><em>Era revolusi industri 4.0 merupakan era di mana kehidupan manusia selalu berkaitan dengan teknologi dan informasi</em><em>. </em><em>Salah satu contoh kegiatan yang berhubungan dengan teknologi dan informasi di madrasah adalah pembelajaran dalam jaringan (daring). Pembelajaran daring dapat meningkatkan hasil belajar, kemampuan berpikir kritis, dan motivasi belajar siswa. Aplikasi pembelajaran daring sudah banyak dijumpai di internet, antara lain Schoology, Edmodo, Google Classroom, Rumah Belajar, Phet Colorado, Quizziz, dan lain-lain. Quizziz merupakan aplikasi yang mendukung tentang penyelenggaraan UH, UTS, dan UAS secara online. Penggunaan aplikasi dalam ulangan harian dapat membantu guru mengurangi kesalahan dalam penilaian. Aplikasi Quizzez juga efektif digunakan dalam pelatihan pembuatan soal berbasis daring karena lebih sederhana dalam penerapannya.</em><em></em></p>
Penguatan Relasi Multikultural Dengan Literasi Digital Di Desa Pait Kasembon Malang
Authors: Chotimah Dien Nur , Sutaman Sutaman 
Published: August 2020

<p class="ABSTRACTJUDUL"><em>This dedication’s to society activity that have been conducted in Pait Village, Kasembon District, Malang take the theme building and strengthening multicultural relations. The method used in dedication to society is the Participation Action Research (PAR) method, taking into account the conditions of assistance in the beginning and the conditions of assistance that are expected. Assistance was carried out in a number of Focus Group Discussions (FGD), socialization and some workshops. Strengthening multicultural relations in the people of Pait Village is very necessary given the diversity of different community backgrounds, especially from the religious aspect. This dedication program has resulted in the formation of a Multicultural Literacy Concern (PLM) community. In addition, the authorship assistance program was also carried out for the community members. Even expanding its influence by spreading their ideas through the website ikipait.com. This assistance resulted in a pretty good web design, displaying the writings of PLM community members.</em></p><p class="ABSTRACTJUDUL"><em> </em></p><p class="ABSTRACT"><em>Kegiatan pengabdian kepada masyarakat yang telah dilakukan di Desa Pait, Kecamatan Kasembon, Kabupaten Malang ini mengambil tema membangun dan menguatkan relasi multikultural. Metode yang digunakan dalam pengabdian kepada masyarakat ini adalah metode Participation Action Research (PAR), dengan memperhatikan kondisi dampingan di awal serta kondisi dampingan yang diharapkan. Pendampingan dilakukan dalam beberapa Focus Group Discussion (FGD) dan juga dalam bentuk sosialisasi serta pelaksanaan beberapa workshop. Penguatan relasi multikultural pada warga masyarakat Desa Pait sangat diperlukan mengingat keberagaman latar belakang masyarakat yang berbeda, terutama dari aspek agama. Program pengabdian ini menghasilkan terbentuknya komunitas Peduli Literasi Multikultural (PLM) yang berfungsi untuk menguatkan relasi multikultural. Selain itu, juga terlaksana program pendampingan kepenulisan kepada warga masyarakat. Bahkan meluaskan pengaruhnya dengan menyebarkan ide dan gagasan mereka melalui website ikipait.com. Pendampingan ini menghasilkan desain web yang cukup baik, dengan menampilkan tulisan-tulisan karya anggota komunitas PLM.</em></p>
Penerapan Budaya Pengajaran Ala Pesantren di Lingkungan Dusun Sumberejo Lembeyan Wetan Magetan
Authors: Nurhidayati Maulida , Khasanah Nurul , Pamungkas Ragil 
Published: August 2020

<p class="ABSTRACTJUDUL"><em>Kuliah Pengabdian Masyarakat (KPM) are activities that give students the opportunity to study and work in the community. This KPM is done in Sumber Rejo village Lembeyan Wetan District Magetan which began on 15 July 2019 until 15 August 2019. The activity begins by identifying the assets in Sumber Rejo village to be used for community empowerment. In Sumber Rejo village there are some well-utilized mushola and lack of interest to pray in the mosque. The activity chosen is the study of Mabadi ' Al-Fiqhiyyah by Sheikh Umar Ibn Abdul Jabbar and performed every Maghrib Ba'da in the mosque Nurul Hidayah RT 04 and the mosque Baitul Ikhlas at RT 05 with the division of time. For Mondays to Thursdays, the implementation of the Mabadi ' Al-Fiqhiyyah study activity is located at Mushola Nurul Hidayah. As for Friday to Sunday, this activity is located at the Mosque of Baitul Ikhlas. After the division of this time, to fill the void due to the division of time, in each mosque held also activities Sholawat al-Barzanji. Both activities gave a smooth walk and attracted people to pray in the Mushola.</em></p><p class="ABSTRACTJUDUL"><em> </em></p><p class="ABSTRACTJUDUL"><em>Kegiatan Kuliah Pengabdian Masyarakat (KPM) merupakan kegiatan yang memberikan kesempatan kepada mahasiswa untuk belajar serta bekerja di masyarakat. KPM ini dilakukan di Dusun Sumber Rejo Desa Lembeyan Wetan Kabupaten Magetan yang mulai pada tanggal 15 Juli 2019 sampai dengan 15 Agustus 2019. Kegiatan dimulai dengan mengidentifikasi asset yang ada di Dusun Sumber Rejo untuk dapat dimanfaatkan untuk pemberdayaan masyarakat. Di Dusun Sumber Rejo terdapat beberapa mushola yang masih belum dimanfaatkan dengan baik serta kurangnya minat masyarakat untuk sholat di masjid. Kegiatan yang dipilih adalah kajian kitab Mabadi’ Al-Fiqhiyyah karangan Syekh Umar Ibn Abdul Jabbar dan dilaksanakan setiap ba’da magrib di mushola Nurul Hidayah RT 04 dan mushola Baitul Ikhlas di RT 05 dengan pembagian waktu. Untuk hari senin hingga kamis, pelaksanaan kegiatan kajian kitab Mabadi’ Al-Fiqhiyyah bertempat di Mushola Nurul Hidayah. Sedangkan untuk hari Jum’at hingga minggu kegiatan ini bertempat di Mushola Baitul Ikhlas. Setelah diadakan pembagian waktu ini, untuk mengisi kekosongan karena adanya pembagian waktu, pada masing-masing mushola diadakan pula kegiatan sholawat al-Barzanji. Kedua kegiatan ini memberikan berjalan dengan lancar dan menarik minat masyarakat untuk berjamaah sholat di mushola.</em></p>
Fertilizer effect of composted sewage sludge and cattle manure onPelargoniumgrowth
Authors: Dridi Nesrine , Romdhane Lilia , Ferreira Renata , Sleimi Noomene 
Published: August 2020

AbstractSewage sludge is considered as a main product obtained from urban liquid effluents that are discharged into sanitation systems of wastewater treatment plants. The aim of this work was to reuse it as compost, after the dehydration process, to replace the amendment applied in agriculture and also to reduce the environmental pollution caused by solid wastes. To justify our biotechnological approach, nutrient characterization of the composted dewatered sewage sludge was carried out and compared to cattle manure. The contents of N, P, K, and the organic matter are 3.67, 5.64, 6.60 g·kg-1 dry matter (DM), and 70%, respectively, in compost and 3.1, 1.6, 3.0 g·kg−1 DM, and 55%, respectively, in manure. Fertilization tests with composted dewatered sewage sludge and cattle manure were performed on Pelargonium inquinans. Monitoring the length of the first internodes showed an improvement of 4.2 mm in the length in compost plants with a development of 22.8 buds and 8.2 flower buds (19.4 buds and 4.4 flower buds developed in manure plants). It appears that the intake of composted dewatered sewage sludge ensures better growth for the studied plant due to its richness in nutrients, which confirms the beneficial effect of composting sewage sludge on plant cultivation.
Box-Wilson design modeling of photocatalytic degradation of industrial dye and wastewater in semi-pilot solar photoreactor
Authors: Bouchareb Mohammed Kheir-eddine , Berkani Mohammed , Merouani Slimane , Bouhelassa Mohamed 
Published: August 2020

Abstract
This work focuses on the treatment of a dye solution, C.I. Basic Blue 41 (BB41), and industrial wastewater by UV/TiO2 photocatalytic process using aqueous catalyst suspensions of titanium dioxide (TiO2), Degussa P25. The procedures were carried out in a semi-pilot scale prototype solar photoreactor under solar radiation. Response surface methodology (RSM) based on Box-Wilson design was applied to assess individual effects of the five main independent parameters: initial dye concentration ([BB41]), TiO2 concentration ([TiO2]), flow rate (Q) initial pH and accumulated solar energy (Qvn) on the decolorization efficiency and to optimise the UV/TiO2 process. Photocatalytic mineralisation was carried out at the optimal conditions found by RSM and results were evaluated by total organic carbon (TOC) abatement for BB41 sloution and industrial wastewater. The optimal conditions found by RSM were: 0.4 g/L, 14.04 mg/L, 1,479.6 L/h, 5.52 and 80 KJ/L for TiO2 concentration, initial dye concentration, flow rate, initial pH and accumulated solar energy, respectively. Photocatalytic mineralisation results show that for accumulated visible solar energy equal to 377.714 kJ/L (after 6 hours of irradiation), under these conditions, the percentage of the initial TOC reduction is about 88% and 85.5% for industrial waste and BB41 solution, respectively.
Enhancement of benzene degradation by persulfate oxidation: synergistic effect by nanoscale zero-valent iron (nZVI) and thermal activation
Authors: Jiang Xihao , Lyu Shuguang , Ali Meesam , Huang Jingyao , Jiang Wenchao , Qiu Zhaofu , Sui Qian 
Published: August 2020

Abstract
The feasibility of an advanced oxidation process based upon sodium persulfate (SPS) activated simultaneously by heat (50 °C) and nanoscale zero-valent iron (nZVI) on benzene removal was investigated. The experimental results strongly showed the synergistic effect of thermal and nZVI activation to SPS and benzene removal was enhanced with the increase of SPS/nZVI/benzene molar ratio. Specifically, 94% of benzene could be removed in 1 hr at 50 °C at the SPS/nZVI/benzene molar ratio of 10/5/1. The radical scavenger tests and electron paramagnetic resonance (EPR) analysis confirmed that SO4•− was the predominant species contributing to benzene degradation. Further, the effects of the solution matrix on benzene elimination were investigated. The results indicated that benzene destruction in the thermally activated SPS/nZVI system performed better under acidic conditions, and the high concentration of both Cl− and HCO3− had adverse effects on benzene elimination. The test for the performance of benzene degradation in the actual groundwater demonstrated that benzene could be degraded entirely at SPS/nZVI/benzene molar ratio of 40/40/1 at 50 °C, indicating that the synergistic catalysis of thermal and nZVI activation to SPS is exploitable and the thermally activated SPS/nZVI system can be applicable to the remediation of benzene contaminated groundwater.
Decreto nº 25.667, de 15 de outubro de 1948
Authors: De Araújo Marta Maria 
Published: August 2020

Considerando o disposto no art. 2.º da Lei n.º 59, de 11 de agosto de 1947, o Presidente Eurico Gaspar Dutra (1946-1951) expediu o Decreto nº 25.667, de 15 de outubro de 1948, contendo as instruções para a execução da cooperação financeira com os Estados, Territórios, Municípios, Distrito Federal e Instituições Particulares, destinada à ampliação e à melhoria da rede escolar primária, secundária e normal do país.
No dia 19 de novembro de 1953, foi firmado o Termo do Acordo Especial (abaixo do texto do Decreto), celebrado entre o Instituto de Estudos Pedagógicos (representado pelo professor Anísio Spínola Teixeira) e o Ginásio Diocesano Seridoense de Caicó (representado pelo Sr. Manoel Medeiros Brito) na concessão do auxílio de CR$150,000,00 (Cento e Cinquenta Mil Cruzeiros) para a ampliação e melhoria dessa instituição de Ensino Secundário Católica. Em face da relevância do referido Decreto e do Termo do Acordo Especial para a História da Educação no Brasil e no Rio Grande do Norte, é que se publica nesta Seção de Documento.
Simultaneous UPLC-MS/MS Determination of 6-mercaptopurine, 6-methylmercaptopurine and 6-thioguanine in Plasma: Application to the Pharmacokinetic Evaluation of Novel Dosage forms in Beagle Dogs
Authors: Han Jiaqi , Mei Shenghui , Xu Jiamin , Zhang Dongjie , Jin Siyao , Zhao Zhigang , Zhao Libo 
Published: August 2020

Background:
6-Mercaptopurine (6-MP) is widely used to treat pediatric acute lymphoblastic leukemia
(ALL). Mini-tablets of 5 mg per tablet were developed for precision individual therapy for children and individuals
with poor thiopurine S-methyltransferase (TPMT) or nucleoside diphophate-linked moiety X-type motif 15
(NUDT15) metabolism. This study investigated the pharmacokinetic profiles of mini-tablets and conventional
tablets with an improved ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)
method.

Methods:
After giving 8 healthy beagle dogs 50 mg 6-MP in different dosage forms, plasma samples collected at
different time points were analyzed for pharmacokinetic evaluation. The samples were precipitated by methanol
with 0.05% formic acid and separated on a Waters Atlantis T3 column (2.1 × 150 mm, 3 μm particles) using 0.1%
formic acid in water and methanol at a flow rate of 0.4 mL/min in 4 min.

Results:
This method showed good linearity, accuracy, precision and stability with a detection range of 5.0-500.0
ng/mL for 6-MP, 6-methylmercaptopurine (6-MMP) and 6-thioguanine (6-TG). The main parameters, half-life of
apparent terminal disposition, maximum observed plasma concentration, total AUC extrapolated to infinity, AUC
since initiation of the experiment, mean residence time, distribution volume and clearance were 1.62 ± 0.87 hours,
90.58 ± 60.43 ng/mL, 151.20 ± 94.18 ng·h/mL, 292.06 ± 184.02 ng·h2/mL, 1.90 ± 0.92 hours, 864.08 ± 538.52 L,
and 432.75 ± 360.64 L/h for conventional tablets and 1.70 ± 1.10 hours, 84.15 ± 39.50 ng/mL, 147.70 ± 51.80
ng·h/mL, 300.92 ± 124.48 ng·h2/mL, 2.07 ± 0.50 hours, 756.90 ± 324.00 L, and 340.75 ± 125.81 L/h for minitablets,
respectively. Paired t-tests showed no significant difference in any of the evaluated pharmacokinetic parameters
between the two types tablets (P > 0.05).

Conclusion:
Two dosage forms showed the same pharmacokinetic characteristics. This developing, novel formulation
will help to provide a more accurate and optimal dosing regimen of 6-MP for humans in the future.
In Vitro and Ex Vivo Evaluation of Capparis spinosa Extract to Inactivate Protoscoleces During Hydatid Cyst Surgery
Authors: Mahmoudvand Hossein , Khalaf Amal Khudair , Beyranvand Mania 
Published: August 2020

Background:
Hydatidosis is one of the most dangerous zoonosis diseases in the world
caused by the larval stage of the broad-worm or Echinococcus granulosus parasite. Today, cysts’
rupture or content leakage during surgery and involvement of organs adjacent to the organ involved,
and consequently secondary cysts, are the major concern for hydatid cyst surgeons. Therefore,
using scolicidal substances such as hypertonic saline 20%, silver nitrate and formalin has
been considered to reduce the risk of protoscoleces spread and recurrence of disease in recent
years. The current work was designed to assess the antiparasitic effects of Capparis spinose L. extract
against hydatid cyst protoscoleces.

Methods:
Collected protoscoleces from liver fertile hydatid cysts of infected sheep were exposed
to the different concentrations of the essential oil (150, 300, 600 mg/mL) for 5-60 min in vitro and
ex vivo. Then by using the eosin exclusion assay, the viability of protoscoleces was studied. The primary
phytochemical analysis of the C. spinosa extract was done to assess the presence of tannins,
alkaloids, saponins, flavonoids, terpenoids and glycosides.

Results:
C. spinosa extract exhibited a powerful protoscolicidal activity in vitro so at the dose of
300 and 600 mg/ml, it entirely eliminated the parasite after 10 and 5 minutes; whereas at lower doses,
it demonstrated weak protoscolicidal activity. In ex vivo assay, no similar effect to in vitro assay
was observed, so more time was required to show a potent protoscolicidal activity. C. spinosa extract,
at the concentrations of 300 and 600 mg/mL after an exposure time of 20 and 12 min, killed
100% of protoscoleces within the hydatid cyst, respectively. The findings of primary phytochemical
screening of the C. spinosa extract demonstrated the existence of flavonoids, tannins, terpenoids,
glycosides and alkaloids in this plant.

Conclusion:
The obtained results in vitro and ex vivo exhibited potent protoscolicidal effects of C.
spinosa extract particularly at the concentrations of 600 and 300 mg/ml, which entirely eliminated
the parasite after 5-20 min exposure. However, more supplementary works are required to verify these
findings through assessing in animal models and clinical subjects.
Novel Coumarin Containing Dithiocarbamate Derivatives as Potent α-Glucosidase Inhibitors for Management of Type 2 Diabetes
Authors: Mollazadeh Marjan , Mohammadi-Khanaposhtani Maryam , Valizadeh Yousef , Zonouzi Afsaneh , Faramarzi Mohammad A. , Kiani Mitra , Biglar Mahmood , Larijani Bagher , Hamedifar Haleh , Mahdavi Mohammad , Hajimiri Mir Hamed 
Published: August 2020

Background:
α-Glucosidase is a hydrolyzing enzyme that plays a crucial role in the degradation
of carbohydrates and starch to glucose. Hence, α-glucosidase is an important target in carbohydrate
mediated diseases such as diabetes mellitus.

Objective:
In this study, novel coumarin containing dithiocarbamate derivatives 4a-n were synthesized
and evaluated against α-glucosidase in vitro and in silico.

Methods:
These compounds were obtained from the reaction between 4-(bromomethyl)-7-
methoxy-2H-chromen-2-one 1, carbon disulfide 2, and primary or secondary amines 3a-n in the
presence of potassium hydroxide and ethanol at room temperature. In vitro α-glucosidase inhibition
and kinetic study of these compounds were performed. Furthermore, a docking study of the most
potent compounds was also performed by Auto Dock Tools (version 1.5.6).

Results:
Obtained results showed that all the synthesized compounds exhibited prominent inhibitory
activities (IC50 = 85.0 ± 4.0-566.6 ± 8.6 μM) in comparison to acarbose as a standard inhibitor
(IC50 = 750.0 ± 9.0 μM). Among them, the secondary amine derivative 4d with pendant indole
group was the most potent inhibitor. Enzyme kinetic study of the compound 4d revealed that this
compound competes with a substrate to connect to the active site of α-glucosidase and therefore is
a competitive inhibitor. Moreover, a molecular docking study predicted that this compound interacted
with the α-glucosidase active site pocket.

Conclusion:
Our results suggest that the coumarin-dithiocarbamate scaffold can be a promising lead
structure for designing potent α-glucosidase inhibitors for the treatment of type 2 diabetes.
Phytophenolics Composition of the Methanol Extract of Ocimum basilieum L. leaves and its Role in Mitigating Hypercholesterolemia in a Rat Model
Authors: El-Hagrassi Ali M. , Aboul Naser Asmaa F. , Osman Abeer F. , Hamed Manal A. 
Published: August 2020

Background:
Hypercholesterolemia is considered as one of the major risk factors for
atherosclerosis. The study aimed to evaluate the effect of Ocimum basilieum L. against hypercholesterolemia
in rats.

Methods:
Isolation and identification of flavonoid compounds from the methanolic extract of Ocimum
basilicum L. leaves were performed by UV, 1H, 13C-NMR and1D/2D NMR, HMBC and
HMQC techniques. The biochemical evaluation was performed through measuring Total Cholesterol
(TC), High Density Lipoprotein-Cholesterol (HDL-C), Low Density Lipoprotein-Cholesterol
(LDL-C), Triglycerides (TG), Malondialdehyde (MDA), Glutathione (GSH), Total Antioxidant Capacity
(TAC), aspartate and Alanine Aminotransferases (AST & ALT), Alkaline Phosphatase
(ALP), urea, creatinine and albumin levels as well as DNA fragmentation pattern of kidneys. The
histopathological features of liver and kidney were also examined.

Results:
The phytochemical study revealed the presence of seven flavonoid compounds (apigenin-
8-C-(α-L-rhamnopyranosyl-(1→2)-β-O –glucopyranoside (1), apigenin 6, 8-di-C-β-glucopyranoside
(vicenin 2) (2), apigenin 7-O-(6”-O-trans-p-coumaryl)-β–glucopyranoside (3), apigenin 7-O-
β-glucopyranoside (4), apigenin 8-C-β-glucopyranoside (vitexin) (5), apigenin -6-C-β-glucopyranoside
(isovitexin) (6), apigenin (7)) and one phenolic compound; rosmarinic acid (8). Treatment
with leaves extract at a dose of 250 mg/kg body weight for nine weeks simultaneously with oral
cholesterol administration (30 mg/0.3 ml 0.7% tween/ animal) to rats fed with high fat diet restored
all the biochemical parameters and the architectures of liver and kidney.

Conclusion:
Methanolic extract of Ocimum basilieum L. leaves succeeded to act as a hypolipidemic,
antioxidant and hepato-renal therapeutic agent due to its rich biologically active phenolic and
flavonoids compounds.