bluuebunny/crossref_metadata_2025_split huggingface dataset:
In silico pathway analysis based on Chromosomal Instability in Breast Cancer Patients
Authors: KOUR AKEEN , Sambyal Vasudha , Guleria Kamlesh , Singh Neeti Rajan , Uppal Manjit Singh , Manjari Mridu , Sudan Meena 
Published: January 2020

Abstract
Background: Complex genomic changes that arise in tumors are a consequence of chromosomal instability. In tumor cells genomic aberrations disrupt core signaling pathways involving various genes, thus delineating of signaling pathways can help understand the pathogenesis of cancer. The bioinformatics tools can further help in identifying networks of interactions between the genes to get a greater biological context of all genes affected by chromosomal instability. Results: Karyotypic analyses was done in 150 clinically confirmed breast cancer patients and 150 age and gender matched healthy controls after 72 hours Peripheral lymphocyte culturing and GTG-banding. Karyotypic analyses found more frequent chromosomal aberrations (structural and numerical) on chromosome 1, 2, 3, 4, 5, 8, 9, 17 and X. The data of genes harbored by chromosomal regions showing increased aberration frequency was retrieved from online databases. Pathway analysis on a set of genes that were not linked together revealed that genes HDAC3, NCOA1, NLRC4, COL1A1, RARA, WWTR1, and BRCA1 were enriched in the RNA Polymerase II Transcription pathway which is involved in recruitment, initiation, elongation and dissociation during transcription. Conclusion: The chromosomal instability analysis in a non-target in cancer patients thus can be used to identify genes and decipher the pathway involved in tumorigenesis. The bioinformatics approach can help in identifying aberrant genes in transcription pathways and their relation with breast cancer progression.
Diseases spectrum of older patients: An age stratified analysis in a new model of Telemedicine
Authors: Gong Yu , Zhou Jianyuan 
Published: January 2020

Abstract
Background: Medical service for the older patients is a worldwide challenge for the public health system. Telemedicine is the new development of traditional clinical medicine and can provide an innovative method of medical services for the older adults and effectively solve the problem. A new model of telemedicine jointly performed by general practitioners and specialists in a university teaching hospital has been established. Different from the existing telemedicine models that had been widely adopted, it provides a solution for the key issues in telemedicine where a doctor is unable to conduct a direct physical examination and the associated diagnostic error. The joint telemedicine center is supported by multi-disciplinary medical experts of a university teaching hospital and supervised by the government health administrative department which ensures the quality of medical practice.Method: The aim of the study is to perform age stratified analysis of disease spectrum of older patients receiving telemedicine and determine the main diseases in different age groups of older patients. 472 older patients (aged≥60) were enrolled and divided into the young older group (aged 60 to 74), the old older group (aged 75 to 89) and the very old group (aged≥90) according to the new age stratification of older people defined by World Health Organization. Proportion of the top 10 diseases of older patients of different age groups was analyzed.Results: Coronary heart disease and type 2 diabetes mellitus were identified as the top two diseases in the older patients and the young older patients as well as the old older patients receiving telemedicine.Conclusions: The new model of telemedicine can provide convenient and efficient medical services for older patients and overcome the disadvantage of currently used models of telemedicine. Different disease spectrum characteristics were identified in different age groups of older patients receiving telemedicine. Coronary heart disease and type 2 diabetes mellitus were found as the main diseases of the older patients receiving telemedicine. The results of this study will provide basis for the health administrative departments to formulate health policies for older patients.
Establishing the criterion validity of the interRAI Check-Up Self-Report instrument
Authors: Geffen Leon Neville , Kelly Gabrielle , Morris John N , Hogeveen Sophie , Hirdes John 
Published: January 2020

Abstract
Background: Low and middle-income countries have growing older populations and could benefit from the use of multi-domain geriatric assessments in overcoming the challenge of providing quality health services to older adults. This paper reports on the outcomes of a study carried out in Cape Town, South Africa on the validity of the interRAI Check-Up Self-Report instrument, a multi-domain assessment instrument designed to screen older adults in primary health settings. The instrument is designed to identify specific health problems and needs, including psychosocial or cognition problems and issues related to functional decline. The interRAI Check-Up Self-Report is designed to be compatible with the clinician administered instruments in the interRAI suite of assessments. We sought to establish whether community health workers, rather than trained healthcare professionals could reliably administer the instrument.Methods: We evaluated the validity of the self-report instrument through comparison to assessments completed by clinicians. A total of 112 participants, aged 60 or older were recruited from 6 seniors clubs in Khayelitsha, Cape Town. Each participant was assessed by one of two previously untrained, non-healthcare personnel using the Check-Up Self-report version and again by a trained assessor using the clinician version of the interRAI Check-Up within 48 hours. Our analyses focused on the degree of agreement between the self-reported and clinician-rated versions of the Check-Up based on the simple or weighted kappa values for the two types of ratings. Binary variables used simple kappas, and ordinal variables with three or more levels were examined using weighted kappas with Fleiss-Cohen weights.Results: Based on Cohen’s Kappa values, we were able to establish that high levels of agreement existed between clinical assessors and lay interviewers, indicating that the instrument can be validly administered by community health workers without formal healthcare training. Conclusion: Our findings indicate that there is potential for the Check-Up Self-Report instrument to be implemented in under-resourced health systems such as South Africa’s.
Prevalence of Generalized Joint Hypermobility in Children with Anxiety Disorders
Authors: javadi vadood , Modarres Shadi Sadat , Zahed Ghazal , Shiari Reza , Rahmani Khosro 
Published: January 2020

Abstract
Background Concerning the high prevalence of anxiety disorders and joint hypermobility in children and the lack of related studies in this age group, we aimed to assess the relationship between the prevalence of hypermobility and anxiety disorders in children. MethodsIn this case-control study, 93 children ages 8-15 years with anxiety disorders referring to the Child and Adolescent Psychiatry Clinic of Mofid Children’s Hospital, Tehran, Iran, during 2018, were enrolled. The control group consisted of 100 age and sex-matched children without anxiety disorders. Anxiety was evaluated using the Spence Children Anxiety Scale (SCAS). The diagnosis of generalized joint hypermobility was done based on Beighton and Shiari-Javadi criteria. Results Based on Beighton’s diagnostic criteria 52.7% of the children in the case group and 16% of the children in the control group had generalized joint hypermobility. Moreover, based on Shiari-Javadi criteria, 49.5% and 13% of the children in the case and control groups had generalized joint hypermobility, respectively. Moreover, the internal correlation between the two criteria was 0.91 showing almost complete compatibility between the two (P<0.001). Age was a risk factor that could predict hypermobility in these children. Other variables such as sex, severity, and type of anxiety disorders, and ADHD, were not predictors of hypermobility syndrome. Conclusion The prevalence of hypermobility was three times higher in children with anxiety disorders and only age was a predictor for the possibility to suffer from generalized joint hypermobility in these children.
Two-stage Exchange Arthroplasty is a Viable Treatment for Periprosthetic Joint Infection in Inflammatory Diseases
Authors: Jiang Qiao , Fu Jun , Xu Chi , Chai Wei , Hao Li-Bo , Zhou Yong-Gang , Chen jiying 
Published: January 2020

Abstract
Aims The aims of this study were to identify the differences in (1) serum markers, synovial indicators and pathology results and (2) treatment outcomes following two-stage exchange arthroplasty between patients with or without inflammatory diseases. Patients and Methods A retrospective review of 182 prosthetic joint infection patients who underwent two-stage exchanged arthroplasty from 2014 to 2017 was conducted. PJI was diagnosed by using the MSIS criteria. Serum biomarkers, synovial fluid, organism and pathology results at the time of the PJI diagnosis and reimplantation were reviewed and compared between patients with or without inflammatory diseases. Treatment success was defined according to the Delphi consensus criteria; Kaplan-Meier survivorship curves of the patients were generated and compared. The mean clinical follow-up duration was 33.9 months (15.9 to 51.9) in the no inflammatory group and 35.5 months (16.2 to 54.8) in the inflammatory group. Results There was no difference in the biomarkers, pathology results or organism profile at the time of the PJI diagnosis. Regarding reimplantation, the patients with inflammatory diseases had a higher serum erythrocyte sedimentation rate and C-reactive protein, interleukin-6, and fibrinogen values than those without inflammatory diseases. However, there was no difference in the synovial white blood cell counts between groups. The total treatment success rate was 91.3% (92% for individuals with inflammatory diseases and 91.2% for the controls). The survivorship of the inflammatory disease group was comparable with that of the control group. Conclusion Two-stage exchange arthroplasty is a viable treatment option for PJIs with inflammatory diseases. Individuals with PJIs and inflammatory diseases have higher serum inflammatory biomarker levels at reimplantation, which may make determining the timing of reimplantation difficult. In contrast, synovial analysis may be more reliable.
Mid- and long-term efficacy of surgical treatment of Vancouver B2 and B3 periprosthetic femoral fractures
Authors: Sun Jian-Ning , Zhang Yu , Zhang Ye , Zhang Jia-Ming , Chen Xiang-Yang , Feng Shuo 
Published: January 2020

Abstract
Background: The incidence of fractures around the femoral prosthesis among patients undergoing hip arthroplasty is increasing and has become the third leading cause of hip revision. While numerous methods for the surgical treatment of periprosthetic femoral fractures (PFFs) have been proposed, only few reports have examined the long-term efficacy of surgical treatment. This study aims to examine the mid-and long-term efficacy of surgical treatment among patients with Vancouver B2 and B3 PFFs.Methods: This retrospective study evaluated the surgical outcomes of patients with Vancouver B2 and B3 PFFs between 2007 and 2011. The minimum follow-up time was eight years. Fracture healing, prosthesis stability, complications, patient quality of life SF-36 score, and survival rate were evaluated during the follow-up assessments.Results: A total of 83 patients were included and had an average follow-up period of 120.3 months. Among these patients, 69 were classified as Vancouver B2 and were treated with a distal fixation stem, whereas 14 cases were classified as Vancouver B3 and were treated with modular femoral prosthesis by using a proximal femoral allograft technique. A total of 15 patients underwent secondary revision surgery, and prosthesis dislocation was identified as the main cause of secondary revision. 80 (96.4%) cases of fractures were clinically healed. The mortality rate in the first year after surgery was 8.4% (7/83). The overall 5-year Kaplan–Meier survival rate for these patients was 75.9%. Meanwhile, the 5-year Kaplan–Meier survival rate for the implants was 86.9%. The final follow-up SF-36 score of the patients was 48.3 ± 9.8.Conclusions: Patients with Vancouver B2 and B3 PFFs show high mortality in the first year after their surgery, and the Kaplan–Meier analysis results showed that such mortality tends to plateau after 5 years. Prosthesis dislocation was identified as the primary cause of secondary revision.
THE ELEVATED RISK OF MELANOMA AMONG PILOTS – COULD UVA BE IMPLICATED?
Authors: Emslie Nicola 
Published: January 2020

ABSTRACT
A number of studies indicate that pilots have approximately double the risk of developing melanoma compared to the general population. It is not clear which aetiological factors underpin this increase in risk. Possibilities include leisure time sun exposure, cosmic radiation, circadian rhythm disruption and UV exposures in the cockpit. This brief review presents some of the key research on exposures of interest, with a focus on UV radiation. It highlights the need for further research assessing UVA levels within the cockpit of flying aircraft, given the possibility that glass windscreens may not be particularly effective at blocking UVA.
Comparative study on decentralized treatment technologies for sewage and graywater reuse – a review
Authors: Bajpai Mukul , Katoch Surjit Singh , Chaturvedi Naveen Kumar 
Published: January 2020

AbstractCurrently, reservoirs, lakes, rivers etc. are being overloaded by the demand for fresh water, due to rapid industrialization and population explosion, and also the effluents from industries and domestic wastewater are continuously polluting these resources. To address this issue, several decentralized wastewater treatment system (DWTS) have been installed all over the globe to reuse and recycle wastewater/graywater for non-potable uses such as fire protection, toilet-flushing, and landscape irrigation. In this review, a comparison between different DWTS was carried out to evaluate their performance, merits and limitations. Hybrid technologies like the electrically enhanced biomass concentrator reactor and integration of physical/ biological methods with bio-electrochemical systems such as microbial fuel cells were found to be the most promising methods for near complete removal of pollutants from wastewater and also the issue of membrane fouling was reduced to a good extent.
Protective Role of Natural Products in Glioblastoma Multiforme: A Focus on Nitric Oxide Pathway
Authors: Afshari Amir R. , Mollazadeh Hamid , Mohtashami Elmira , Soltani Arash , Soukhtanloo Mohammad , Hosseini Azar , Jalili-Nik Mohammad , Vahedi Mohammad Mahdi , Roshan Mostafa Karimi , Sahebkar Amirhossein 
Published: January 2020

:In spite of therapeutic modalities such as surgical resection, chemotherapy, and radiotherapy, Glioblastoma Multiforme (GBM) remains an incurable fatal disease. This necessitates further therapeutic options that could enhance the efficacy of existing modalities. Nitric Oxide (NO), a short-lived small molecule, has been revealed to play a crucial role in the pathophysiology of GBM. Several studies have demonstrated that NO is involved in apoptosis, metastasis, cellular proliferation, angiogenesis, invasion, and many other processes implicated in GBM pathobiology. Herein, we elaborate on the role of NO as a therapeutic target in GBM and discuss some natural products affecting the NO signaling pathway.
Purification and Characterization of Natural Solid-Substrate Degrading and Alcohol Producing Hyperthermostable Alkaline Amylase from Bacillus cereus (sm-sr14)
Authors: Sahoo Sumit , Roy Sudipta , Santra Dipannita , Maiti Sayantani , Roul Sonali , Maiti Smarajit 
Published: January 2020

Objective:Amylases enzymes hydrolyze starch molecules to produce diverse products including dextrins, and progressively smaller polymers. These include glucose units linked through α-1- 1, α-1-4, α-1-6, glycosidic bonds.Methods:This enzyme carrying an (α /β) 8 or TIM barrel structure is also produced containing the catalytic site residues. These groups of enzymes possess four conserved regions in their primary sequence. In the Carbohydrate-Degrading Enzyme (CAZy) database, α-amylases are classified into different Glycoside Hydrolase Families (GHF) based on their amino acid sequence. The present objective was to study one such enzyme based on its molecular characterization after purification in our laboratory. Its main property of solid-natural starch degradation was extensively investigated for its pharmaceutical/ industrial applications.Results:Amylase producing bacteria Bacillus cereus sm-sr14 (Accession no. KM251578.1) was purified to homogeneity on a Seralose 6B-150 gel-matrix and gave a single peak during HPLC. MALDITOF mass-spectrometry with bioinformatics studies revealed its significant similarity to α/β hydrolase family. The enzyme showed an efficient application; favourable Km, Vmax and Kcat during the catalysis of different natural solid starch materials. Analysis for hydrolytic product showed that this enzyme can be classified as the exo-amylase asit produced a significant amount of glucose.Conclusion:Besides the purified enzyme, the present organism Bacillus cereus sm-sr14 could degrade natural solid starch materials like potato and rice up to the application level in the pharmaceutical/ industrial field for alcohol production.
Inhibition of Hemoglobin Degrading Protease Falcipain-2 as a Mechanism for Anti-Malarial Activity of Triazole-Amino Acid Hybrids
Authors: Singh Vigyasa , Hada Rahul Singh , Uddin Amad , Aneja Babita , Abid Mohammad , Pandey Kailash C. , Singh Shailja 
Published: January 2020

Background:
Novel drug development against malaria parasite over old conventional antimalarial
drugs is essential due to rapid and indiscriminate use of drugs, which led to the emergence of resistant
strains.

Methods:
In this study, previously reported triazole-amino acid hybrids (13-18) are explored against
Plasmodium falciparum as antimalarial agents. Among six compounds, 15 and 18 exhibited antimalarial
activity against P. falciparum with insignificant hemolytic activity and cytotoxicity towards HepG2
mammalian cells. In molecular docking studies, both compounds bind into the active site of PfFP-2 and
block its accessibility to the substrate that leads to the inhibition of target protein further supported by
in vitro analysis.

Results:
Antimalarial half-maximal inhibitory concentration (IC50) of 15 and 18 compounds were found
to be 9.26 μM and 20.62 μM, respectively. Blood stage specific studies showed that compounds, 15 and
18 are effective at late trophozoite stage and block egress pathway of parasites. Decreased level of free
monomeric heme was found in a dose dependent manner after the treatment with compounds 15 and 18,
which was further evidenced by the reduction in percent of hemoglobin hydrolysis. Compounds 15 and
18 hindered hemoglobin degradation via intra- and extracellular cysteine protease falcipain-2 (PfFP-2)
inhibitory activity both in in vitro and in vivo in P. falciparum.

Conclusion:
We report antimalarial potential of triazole-amino acid hybrids and their role in the inhibition
of cysteine protease PfFP-2 as its mechanistic aspect.
Aluzje eucharystyczne w Liście do Hebrajczyków
Authors: Mańka Kamil P. 
Published: January 2020

Artykuł ma na celu dodanie dwóch zastrzeżeń do dyskusji na temat aluzji eucharystycznych w Liście do Hebrajczyków, jak również dostarczyć analizy dwóch fragmentów Listu uwzględniającej owe zastrzeżenia. Pierwsze to propozycja „ochrony świętej formuły” wyrażona przez Joachima Jeremiasa; druga to rozumienie Chrystusowej ofiary w Hbr zasadniczo nie w kategoriach śmierci na krzyżu, ale ofiarowania zmartwychwstałego Chrystusa w niebie wedle wyjaśnienia Davida Moffitta. Omawiane fragmenty Listu to Hbr 9, 19–22 i 13, 9–13.
Тригонометрические суммы в метрической теории диофантовых приближений
Authors: Ковалевская Элла Ивановна 
Published: January 2020

Это обзор результатов по метрической теории диофантовых приближений на многообразиях в n-мерном евклидовом пространстве, в доказательстве которых используются тригонометрические суммы.Мы приводим как классические теоремы, так и современные результаты для многообразий Γ, dim Γ = m, n/2 < m < n. Мы также показываем, как происходит переход от задачи о диофантовых приближениях к оценке тригонометрической суммы или тригонометрического интеграла, и приводим необходимые соображения теории меры.Если m ≤ n/2, то обычно используют другие методы. Например, метод существенных и несущественных областей или методы эргодической теории.Здесь даны две фундаментальные теоремы рассматриваемой теории. Одну из них в 1977 г. доказал В. Г. Спринджук. Другую теорему в1998 г. получили Д. И. Клейнбок и Г. А. Маргулис. Первая теорема была доказана методом тригонометрических сумм. Вторая теорема – методами эргодической теории. Для ее доказательства авторами была найдена связь между диофантовыми приближения и однородными динамическими системами.В заключении кратко упоминаем о тенденциях развития метрической теории диофантовых приближений зависимых величин, даем ссылки на ее современные аспекты.
BUSINESS INTELLIGENCE NO SISTEMA NACIONAL DE JUVENTUDE: UM ESTUDO DE CASO DO SOFTWARE VISÃO
Authors: Silveira Lucas , Barcelos Janinne , Dos Santos de Moura Rebeca , Shintaku Milton 
Published: January 2020

Business Intelligence em português, inteligência de negócios, é um conjunto de teorias, metodologia e processos que transformam uma grande quantidade de dados brutos em informações concretas no auxílio a gestão de negócios úteis na tomadas de decisões estratégicas. Originalmente, o conceito era aplicado em empresas privadas para aumentar os ganhos e enxugar custos.
O conceito vem tendo sucesso, e atualmente ultrapassou as barreiras da iniciativa privada, chegando ao poder público. Por ser genérico, o conceito pode ser aplicado no poder público, sem grandes mudanças. Os dados brutos, que antes não tinha nenhum cuidado, podem ser exploradas como fonte de informações valiosas, seja no ganho indireto, através do desperdício de verbas públicas, ou mesmo para mapear a melhor forma de se gastar uma verba, potencializando a cobertura da população. Pensando nisso, a Secretaria Nacional da Juventude desenvolveu uma parceria com o Instituto Brasileiro de Informação em Ciência e Tecnologia (IBICT), para mapear todas as unidades de juventude espalhadas no território brasileiro, possibilitando as gestores criar um observatório de unidades de juventude. Além disso, tal ferramenta, tinha o objetivo de criar, estruturar e expor indicadores de juventude aos gestores das unidades de juventude. O IBICT desenvolveu uma ferramenta web de gestão genérico, conhecida como VISÃO, que está sendo aproveitada nessa parceria, mas que pode ser adaptado para quaisquer outras secretarias ou órgãos para fazer o mapeamento e a gestão dos seus dados. O VISÃO, apresenta uma designer iterativo no qual gestores podem consultar as unidades de forma transparente utilizando a geolocalização destas unidades. A ferramenta também fornece suporte a criação de indicadores de juventude e métodos de criação de relatórios que possam ser utilizados na tomada de decisões. Atualmente, a ferramente encontra-se em estado de alimentação, com dados fornecidos pelo IBGE e ministério da saúde.