bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomechanical effects of stitches on the intra-articular mid-substance of quadruple hamstring-tendon grafts for anterior cruciate ligament reconstruction – a pilot comparative cadaveric study
Authors: Saur Maurise , Clavert Philippe , Bonnomet François , Favreau Henri , Ehlinger Matthieu 
Published: July 2020

Abstract
Background
There is little data in the literature regarding the preparation methods of the intra-articular portion of quadruple hamstring-tendon grafts for anterior cruciate ligament (ACL) reconstruction. The aim of this study was to compare the biomechanical properties of a sutured transplant to that of a non-sutured transplant. The hypothesis was that adding stitches to the intra-articular portion of the graft increased its resistance.

Method
A comparative cadaveric study was carried out on five pairs of knees. The average age of the cadavers was 68 years. The exclusion criterion was past knee surgery. In the Sutured Group (SG) two stitches were made on the grafts. No stitches were made on the grafts of the Non-sutured Group (NSG). A tensile failure test was carried out using an Instron® loading machine. The maximal load to failure and stiffness were recorded and we observed the mode of failure for each graft. Statistical analysis was performed using the Wilcoxon rank sum test. Level of significance was set at p < 0.05.

Results
The hypothesis proposed was not confirmed; adding stitches to the intra-articular portion of the four-strand hamstring-tendon graft does not increase its biomechanical properties. The maximal load to failure was 233.5 N ± 40.6 (186.7–274.5 N) for the NSG, 19.6% higher than for the SG which was 195.2 N ± 42.9 (139.0–238.2 N). Nevertheless, the difference observed was not statistically significant (p = 0.188). The stiffness of the grafts for the NSG was 23.5 N/mm ± 5.3 (17.8–29 N/mm) and 19.7 N/mm ± 5.5 (13.2–24.7 N/mm) for the SG grafts. Overall stiffness values for the NSG were 19% higher than those of the SG; however, the results were not statistically significant (p = 0.438). The failure mode was a rupture at the fixation point except for one sample from the SG which failed at an intra-articular stitch.

Conclusion
Whilst the initial hypothesis was not verified, nevertheless, the maximal loads to failure and stiffness were approximately 20% higher when there were no intra-articular stitches compared to the situation where stitches were added to the intra-articular portion of the graft. This was a cadaveric pilot study and, therefore, whilst we are not able to extend our results to clinical practice, the outcomes would indicate the need for further development of this and related protocols deriving from the question of whether there is weakening the graft when adding stitches to its mid-substance. These results remain to be confirmed by further research.
Whole body diffusion-weighted MRI in detection of metastasis and lymphoma: a prospective longitudinal clinical study
Authors: Goda Heba H. , AbdAllah Abd Elkareem H. , Ahmed Eman A. , Megally Hassan I. , Khalaf Marwa I. , Taha Ahmed M. , Mohamed Hosam Eldeen G. 
Published: July 2020

Abstract
Background
Whole-body diffusion-weighted magnetic resonance imaging (WB-DWI-MRI) is an emerging tool that has an increasing role in the diagnosis of metastasis and lymphoma. This is a longitudinal study in actual clinical settings designed to assess WB-DWI-MRI in detection of tumor spread. The study included all patients who were referred to Radiology Department, during the period from June 2016 till May 2018, with either a known primary tumor (either laboratory, radiologically, or histologically proven, of any type, affecting any organ) or with biopsy-proven lymphoma of any subtype, affecting any organ. All patients underwent WB coronal T1-weighted, STIR, axial T2-weighted, and DWI-MRI examinations before commencing any treatment with curative intent. The body was divided into lymph nodes (LNs), skeletal system, and organs (brain, lung, and liver). Patients were followed up till the nature of the lesion(s) was confirmed (clinically, radiologically, or histologically).

Results
The study included 46 patients; 27 patients had metastases and 19 had lymphomas. Sensitivities, specificities, and accuracies for LN detection were 77%, 85%, and 83%; for skeletal metastasis were 88%, 94%, and 92%; for brain lesions were 78%, 95%, and 91%; and for lung lesion were 64%, 88%, and 76%, respectively. As for the liver, all lesions were correctly identified and did not miss any lesion with accuracy of 100%. Overall, 1739 lesions were discovered in 1271 regions out of 3818 examined regions with overall sensitivity, specificity, and accuracy of 86%, 92%, and 90% respectively.

Conclusion
The diagnostic performance of WB-DWI-MRI is variable among different anatomical sites. It has good performance in diagnosis of some organs as liver, bone marrow, and some LNs regions as porta-hepatis. It has a less diagnostic performance in the lung, and LNs located in cervical, mediastinum, supraclavicular, and mesenteric regions.
Versatile mechanisms of 2-substituted benzimidazoles in targeted cancer therapy
Authors: Ibrahim Heba A. , Refaat Hanan M. 
Published: July 2020

Abstract
Background
The aim of this review is to provide an overview on diverse anticancer activities of 2-substituted benzimidazole derivatives.

Main body
This review provides a correlation between the various mechanisms of action of benzimidazoles as anticancer and the substitution pattern around the nucleus.

Conclusion
The linker group and substitution at N-1, C-2, C-5, and C-6 positions have been found to be the most contributory factors for anticancer activity. This will help in the further design to afford more selective, potent, and multi-target anticancer of 2-substituted benzimidazole-based compounds.
RP-HPLC method development and validation for bedaquiline fumarate to evaluate its forced degradation behaviour and stability in official dissolution media
Authors: Pardhi Vishwas , Pant Geetanjali , Flora S. J. S. 
Published: July 2020

Abstract
Background
A simple, rapid and accurate reverse phase RP-HPLC method for the validation of antitubercular drug bedaquiline fumarate (BQF) was developed. The stability and forced degradation behaviour of bedaquiline fumarate (BQF) in official dissolution media (0.01 N HCl) and methanol were assessed.

Results
The method provided linear responses within the concentration range which varies from 10 to 100 μg/mL with LOD values of 2.6 μg/mL and LOQ of 7.9 μg/mL. Mean percent recovery varied between 97.46 and 103.82% and precise mean RSD of 0.31% (repeatability) and 0.48% (intermediate precision). The method was validated for other parameters like specificity, system suitability and robustness. Potential degradation of the BQF when exposed to direct sunlight in official dissolution media was 90.75% and in methanolic stock solution was 91.98%. Acid-alkali degradation study showed 86.59% loss of BQF in 0.5 N NaOH, and in acidic environment (0.5 N HCl), there was 6.15% loss. Thermal degradation of BQF was 70.11% loss in official dissolution media at 80 °C. No significant change in drug concentrations was noted when exposed and protected from normal daylight at room temperature and at 2–8 °C temperature.

Conclusion
The developed method has significant applicability for the qualitative and quantitative determination of BQF in different pharmaceutical formulations in the official dissolution media in routine quality control analysis.
ASCO Quality Training Program: A Five-Year Review
Authors: Keng Michael , Quinn Doris , Cunningham Gene , Bingham John , Chiang Anne , Eisinger Michael , Gilligan Timothy , Gilmore Terry , Guerrier Vedner , Karri Sirisha , Kaufman Laurie , Mohamed Ashraf , Srivastava Piyush 
Published: July 2020

PURPOSE: ASCO introduced the Quality Training Program (QTP) in 2013 with the aim to train oncology professionals to design, implement, and lead successful quality improvement (QI) activities and assume leadership positions to champion culture change in their practices. METHODS: The QTP is a formal 6-month program taught by QI faculty and mentored by QI coaches over 5 days of in-person learning across 3 sessions and hands-on learning at the participants’ practices. Sessions include seminars, case examples, and small-group exercises. Participants attend in multidisciplinary teams and focus on a problem they wish to solve in their practice. Scheduled conference calls with QI coaches are held between sessions. Participants complete pre- and post-QTP surveys (10-point Likert scale, with 1 = no knowledge/competence and 10 = complete knowledge/competence) and provide direct written feedback. RESULTS: Since its inception, QTP has had 15 courses (10 domestic and 5 international) with 120 teams and 544 total participants. QTP is led by an 8-member steering group with 16 faculty and coaches. All postsurvey items showed an increase in knowledge and competence. Each item’s score was calculated as the mean difference between before and after scores. Participants stated an increase of 46%-84% (overall mean increase: knowledge, 38%; competence, 37%). The greatest increases were in methodology and practical tools to make changes in practice (writing an aim statement, implementing rapid improvement, using process analysis tools, flowcharting the process). The most common suggestion for improvement was allowing more time for the project. Participants are encouraged to write articles and present work in poster and plenary sessions. QTP courses have led to 7 manuscripts and 21 abstract presentations to national meetings. Six QTP alumni are now QI coaches and faculty. CONCLUSION: The QTP is a successful QI course for oncology professionals who need to measure performance, investigate quality and safety issues, and implement change. It is the only oncology-focused QI training, as all faculty and coaches are providers and QI specialists with oncology experience, which makes this a unique opportunity. The success will provide further momentum to offer QTP domestically and around the world.
Circadian Rhythms in Hormone-sensitive Lipase in Human Adipose Tissue: Relationship to Meal Timing and Fasting Duration
Authors: Arredondo-Amador María , Zambrano Carolina , Kulyté Agné , Luján Juán , Hu Kun , Sánchez de Medina Fermín , Scheer Frank A J L , Arner Peter , Ryden Mikael , Martínez-Augustin Olga , Garaulet Marta 
Published: July 2020

Abstract

Background
Fat mobilization in adipose tissue (AT) has a specific timing. However, circadian rhythms in the activity of the major enzyme responsible for fat mobilization, hormone-sensitive lipase (HSL), have not been demonstrated in humans.

Objective
To analyze in a cross-sectional study whether there is an endogenous circadian rhythm in HSL activity in human AT ex vivo and whether rhythm characteristics are related to food timing or fasting duration.

Methods
Abdominal AT biopsies were obtained from 18 severely obese participants (age: 46 ± 11 years; body mass index 42 ± 6 kg/m2) who underwent laparoscopic gastric bypass. Twenty-four-hour rhythms of HSL activity and LIPE (HSL transcript in humans) expression in subcutaneous AT were analyzed together with habitual food timing and night fasting duration.

Results
HSL activity exhibited a circadian rhythm (P = .023) and reached the maximum value at circadian time 16 (CT) that corresponded to around midnight (relative local clock time. Similarly, LIPE displayed a circadian rhythm with acrophase also at night (P = .0002). Participants with longer night fasting duration &gt;11.20 hours displayed almost double the amplitude (1.91 times) in HSL activity rhythm than those with short duration (P = .013); while habitual early diners (before 21:52 hours) had 1.60 times higher amplitude than late diners (P = .035).

Conclusions
Our results demonstrate circadian rhythms in HSL activity and may lead to a better understanding of the intricate relationships between food timing, fasting duration and body fat regulation.
Detection of Mycobacterium tuberculosis DNA in CD34+ peripheral blood mononuclear cells of Ugandan adults with latent infection: a cross-sectional and nested prospective study
Authors: Mayito Jonathan , Andia Biraro Irene , T. Reece Stephen , R. Martineau Adrian , P. Kateete David 
Published: July 2020

Background: Tuberculin skin test and interferon gamma release assay (IGRA) show limitations in diagnosing latent tuberculosis infection (LTBI) and poorly predict progression to active tuberculosis. This study will explore detection of Mycobacterium tuberculosis (M.tb) DNA in CD34+ peripheral blood mononuclear cells (PBMCs) as a biomarker for LTBI and monitoring chemoprophylaxis response. Methods: In a cross-sectional study, 120 household contacts (60 HIV positive and 60 HIV negative) will be recruited. Also, 10 patients with sputum positive pulmonary tuberculosis and 10 visitors from low incidence countries with no history of TB treatment will be recruited as positive and negative controls, respectively. Participants will donate 100 ml (50 ml for TB patients) of blood to isolate PBMCs using density gradient centrifugation. Isolated PBMCs will be separated into CD34+ and CD34- enriched cellular fractions. DNA from each fraction will be purified, quantified and subjected to droplet digital PCR targeting IS6110 (a M.tb Complex multi-copy gene) and rpoB, a single copy gene. Also, 4 ml of blood will be drawn for IGRA. In a nested prospective study, 60 HIV positive participants will be given 300 mg of Isoniazid Preventive Therapy (IPT) daily for six months, after which they will donate a second 100 ml blood sample that will be processed as described above. Data from the cross-sectional study will be analysed to determine the proportion of individuals in whom M.tb DNA is detectable in CD34+ and CD34- fractions and number of M.tb genomes present. Data from the prospective study will be analysed to compare the proportion of individuals with detectable M.tb DNA in CD34+ and CD34- fractions, and median M.tb genome copy number, post vs pre-IPT. Discussion: This study will determine whether detection of M.tb DNA in CD34+ PBMCs holds promise as a biomarker for LTBI and monitoring chemoprophylaxis response.
The relationship between donor-recipient genetic distance and long-term kidney transplant outcome
Authors: Stapleton Caragh P. , Lord Graham M. ,   UK and Ireland Renal Transplant Consortium, Conlon Peter J. , Cavalleri Gianpiero L. 
Published: July 2020

Background: We set out to quantify shared genetic ancestry between unrelated kidney donor-recipient pairs and test it as a predictor of time to graft failure. Methods: In a homogenous, unrelated, European cohort of deceased-donor kidney transplant pairs (n pairs = 1,808), we calculated, using common genetic variation, shared ancestry at the genic (n loci=40,053) and genomic level. We conducted a sub-analysis focused on transmembrane protein coding genes (n transcripts=8,637) and attempted replication of a previously published nonsynonymous transmembrane mismatch score. Measures of shared genetic ancestry were tested in a survival model against time to death-censored graft failure. Results: Shared ancestry calculated across the human leukocyte antigen (HLA) significantly associated with graft survival in individuals who had a high serological mismatch (n pairs = 186) with those who did not have any HLA mismatches indicating that shared ancestry calculated specific loci can capture known associations with genes impacting graft outcome. None of the other measures of shared ancestry at a genic level, genome-wide scale, transmembrane subset or nonsynonymous transmembrane mismatch score analysis were significant predictors of time to graft failure. Conclusions: In a large unrelated, deceased-donor European ancestry renal transplant cohort, shared donor-recipient genetic ancestry, calculated using common genetic variation, has limited value in predicting transplant outcome both on a genomic scale and at a genic level (other than at the HLA loci).
Paleoseismic investigation of the Teton fault at Leigh Lake, Grand Teton National Park, Wyoming
Authors: Thackray Glenn , Zellman Mark , Duross Chris B. 
Published: July 2020

To improve knowledge of the Teton fault’s ground-rupturing earthquake history, we excavated trenches across two fault scarps near the southwest shore of Leigh Lake. Detailed stratigraphic and sedimentologic analyses allow preliminary inferences regarding the fault history. The trenches exposed faulted glacial sediments and overlying hillslope colluvium sediments, documenting at least two fault ruptures since deglaciation of the range front at ~15 ka. Samples are currently being analyzed using radiocarbon and luminescence dating techniques to determine the ages of the sediments and constrain the timing of fault rupture.

Featured photo from Figure 3 in report.
Inspection of disbonds in titanium alloy honeycomb sandwich structures with different skin thicknesses using linear frequency-modulated thermography
Authors: Zhao Hanxue , Zhou Zhenggan , Zhang Defeng , Wang Deguo 
Published: July 2020

This paper reports the linear frequency-modulated thermography inspection of disbonds in titanium alloy honeycomb sandwich structures with different skin thicknesses. A three-dimensional finite element model of a titanium alloy honeycomb sandwich structure is built. The maximum value of the phase difference between the disbond defect region and the nondefective region is used to optimize the heating duration and frequency bandwidth. Three titanium alloy honeycomb sandwich structure specimens, with a skin thickness of 0.6 mm, 0.85 mm, and 1.2 mm, respectively, are manufactured, in which skin-to-core disbond defects are prepared. The linear frequency-modulated thermography experiments are carried out on the specimens. The correlation algorithm is used to process the infrared image sequences. The experimental results show that linear frequency-modulated thermography can realize the fast and efficient inspection of the disbonds in titanium alloy honeycomb sandwich structures with different skin thicknesses. For skin thickness ranges from 0.6 mm to 1.2 mm, a heating duration of 22 s and a frequency range of 0.01 Hz–0.21 Hz are recommended.
Single-shot characterization of strongly focused coherent XUV and soft X-ray beams
Authors: Eschen Wilhelm , Tadesse Getnet , Peng Yufei , Steinert Michael , Pertsch Thomas , Limpert Jens , Rothhardt Jan 
Published: July 2020

In this Letter, we present a novel, to the best of our knowledge, single-shot method for characterizing focused coherent beams. We utilize a dedicated amplitude-only mask, in combination with an iterative phase retrieval algorithm, to reconstruct the amplitude and phase of a focused beam from a single measured far-field diffraction pattern alone. In a proof-of-principle experiment at a wavelength of 13.5 nm, we demonstrate our new method and obtain an RMS phase error of better than

λ

/

70

. This method will find applications in the alignment of complex optical systems, real-time feedback to adaptive optics, and single-shot beam characterization, e.g., at free-electron lasers or high-order harmonic beamlines.
From Obsolete to Contemporary: National Pavilions and the Venice Biennale
Authors: Ricci Clarissa 
Published: July 2020

Abstract
For over a century, the Venice Biennale and its national pavilions have served as a platform for international artistic display. Despite the fact that national representation has been a pivotal aspect of the Biennale since the first pavilion was built in 1907, there is a lack of deep understanding of the nature of this model. The purpose of this article is to offer an historical account of the conceptual and material predicament of national representation at the Venice Biennale. The focus is directed mainly at the introduction in 1993 of a more transnational approach in the context of an increasingly interconnected and globalized world.
What Would Make Morocco an Emerging Economy?
Authors: Naciri Ahmed 
Published: July 2020

Morocco is steadily progressing toward development and may well join the ranks of rich countries as early as in 2022. We perform least squares regressions on a sample of 12 components of economic freedom, for a total of 375 observations over 25 years (1995-2019). We also consider Morocco’s Gross Domestic Product (GDP) in USD billion, Morocco’s GDP growth as a percentage of change (pcGDP)and Morocco’s per capita GDP based on purchasing power parity (PPP) in USD for the last 25 years. The empirical evidence shows that during this period, Morocco achieved an enviable level of performance by increasing its GDP by 455%, despite the strong demographic pressures exerted by 35% population growth.[1]

However, the country’s performance in relation to some components of its economic freedom was so weak that it may end up jeopardizing this economic development momentum, as expressed by the behaviour of its pcGDP and the increase of this value over time. Morocco must introduce some fundamental changes in its economic freedom policies if it wishes to continue to progress. Fortunately, the country appears to have the determination to do so.

[1]According to the IMF, Morocco’s population grew from 26.7995 million in 1995 to 36.47 million in 2019, an increase of 36%.
Reputable Relevant Realistic Reliable and Rigorous Human Resource Management Strategic Approaches and Practices in the 21st century
Authors: Tayali Esnart Mwaba , Sakyi Kwesi Atta 
Published: July 2020

Human resource management is a multi-dimensional and complex phenomenon comprising a number of management themes. Without reputable, relevant, realistic, reliable and rigorous Human Resource Management strategic approaches and practices, companies can fail to effectively operate in a global market. The world has become interconnected as companies operate in a competitive global market economy. Even though Human Resource Management continuously gains scholarly attention yet there are still many gaps in it which need attention. There is no conclusive research on Human Resource Management strategies and approaches in the management of complex workplace issues. These complex issues faced today include convergence, divergence and cross-vergence of International Human Resource Management approaches, Cross-Cultural Management, Reward Strategy, Talent Management, and Control or Commitment Strategy. This paper provides a springboard for a better understanding of the Human Resource Management strategies, approaches and practices in the management of complex workplace issues. Appropriate management of people endows companies with unique and indispensable capabilities and capacities needed for differentiating and survival in a global market economy. The paramount goal of an organisation is to meet and satisfy customer needs and to be a market leader. Reputable, relevant, realistic, reliable and rigorous Human Resource Management strategies can help to fulfil the needs of customers, thereby increasing company profitability.