bluuebunny/crossref_metadata_2025_split huggingface dataset:
Daily self-reported and automatically generated smartphone-based sleep measurements in patients with newly diagnosed bipolar disorder, unaffected first-degree relatives and healthy control individuals
Authors: Stanislaus Sharleny , Vinberg Maj , Melbye Sigurd , Frost Mads , Busk Jonas , Bardram Jakob Eyvind , Faurholt-Jepsen Maria , Kessing Lars Vedel 
Published: August 2020

Objectives(1) To investigate daily smartphone-based self-reported and automatically generated sleep measurements, respectively, against validated rating scales; (2) to investigate if daily smartphone-based self-reported sleep measurements reflected automatically generated sleep measurements and (3) to investigate the differences in smartphone-based sleep measurements between patients with bipolar disorder (BD), unaffected first-degree relatives (UR) and healthy control individuals (HC).MethodsWe included 203 patients with BD, 54 UR and 109 HC in this study. To investigate whether smartphone-based sleep calculated from self-reported bedtime, wake-up time and screen on/off time reflected validated rating scales, we used the Pittsburgh Sleep Quality Index (PSQI) and sleep items on the Hamilton Depression Rating Scale 17-item (HAMD-17) and the Young Mania Rating Scale (YMRS).Findings(1) Self-reported smartphone-based sleep was associated with the PSQI and sleep items of the HAMD and the YMRS. (2) Automatically generated smartphone-based sleep measurements were associated with daily self-reports of hours slept between 12:00 midnight and 06:00. (3) According to smartphone-based sleep, patients with BD slept less between 12:00 midnight and 06:00, with more interruption and daily variability compared with HC. However, differences in automatically generated smartphone-based sleep were not statistically significant.ConclusionSmartphone-based data may represent measurements of sleep patterns that discriminate between patients with BD and HC and potentially between UR and HC.Clinical implicationDetecting sleep disturbances and daily variability in sleep duration using smartphones may be helpful for both patients and clinicians for monitoring illness activity.Trial registration numberclinicaltrials.gov (NCT02888262).
BokSmart rugby safety education courses are associated with improvements in behavioural determinants in attending coaches and referees: presurvey–postsurvey study
Authors: Brown James Craig , Hendricks Sharief , Lambert Michael Ian , van Mechelen Willem , Verhagen Evert 
Published: August 2020

Background/aimBokSmart is a nationwide injury prevention programme that aims to reduce players’ injury risk mainly through education of coaches and referees in mandatory biennial education courses. These courses are held throughout each rugby season. The objective of this cross-sectional study was to assess whether these courses were associated with improvements in attendees’ behavioural determinants.MethodsCoaches and referees completed a questionnaire based on the theory of planned behaviour, immediately before and after their 2012 BokSmart courses. Twelve behavioural determinants were assessed on a five-point Likert scale and open-ended questions. A meaningful change was defined as an improvement of ≥1 unit score supported by null hypothesis testing. Odds of improving by ≥1 unit score (compared with not improving) were assessed in attendees using multivariate logistic regression.ResultsIn total, 390 coaches and 74 referees completed both questionnaires. ‘Before’ scores were high for most outcomes, except for knowledge. Although there was a significant (p<0.001) improvement in all ‘after’ course scores, the only meaningful change (=1 unit) was in knowledge of scrum techniques/rules.ConclusionAlthough the only meaningful improvement in 2012 BokSmart course attendees was in one outcome, it should be noted that before-course scores were already high, reducing the questionnaire’s ability to assess change because of a ceiling effect. Nonetheless, the knowledge acquisition of these courses was low and not related to previous course attendance or more years of rugby experience. These results justify the biennial nature of this safety course but also indicate that knowledge acquisition is generally low.
Immunohistochemistry with anti-MAL antibody and RNAscope with MAL probes are complementary techniques for diagnosis of primary mediastinal large B-cell lymphoma
Authors: Jacquier Anthony , Syrykh Charlotte , Bedgedjian Isabelle , Monnien Franck , Laurent Camille , Valmary-Degano Séverine , Brousset Pierre 
Published: August 2020

AimsPrimary mediastinal large B-cell lymphoma (PMBL) diagnosis can be challenging on needle biopsies. Robust techniques are needed to ensure diagnosis of this lymphoma which is highly sensitive to recently developed therapy protocols.MethodsIn this study, we sought to determine precise PMBL phenotype, compared with diffuse large B-cell lymphoma not otherwise specified, by combining immunohistochemistry with anti-MAL antibody and RNA in situ hybridisation (RNAscope) with specific MAL probes.ResultsThe overall MAL positivity level reached 93% (14/15) of cases of PMBL. Among the 15 cases enrolled in the study, 11 were undoubtedly positive for MAL immunostaining whereas 13 were positive by RNA in situ hybridisation. Interestingly, one case that was negative by in situ hybridisation turned out to be positive by immunohistochemistry.ConclusionsTaken together, our results demonstrate that in situ detection of bothMALtranscripts and protein are complementary and increase the sensitivity and specificity of PMBL diagnosis.
Association between genetic polymorphisms and endometrial cancer risk: a systematic review
Authors: Bafligil Cemsel , Thompson Deborah J , Lophatananon Artitaya , Smith Miriam J , Ryan Neil AJ , Naqvi Anie , Evans D Gareth , Crosbie Emma J 
Published: August 2020

IntroductionEndometrial cancer is one of the most commonly diagnosed cancers in women. Although there is a hereditary component to endometrial cancer, most cases are thought to be sporadic and lifestyle related. The aim of this study was to systematically review prospective and retrospective case–control studies, meta-analyses and genome-wide association studies to identify genomic variants that may be associated with endometrial cancer risk.MethodsWe searched MEDLINE, Embase and CINAHL from 2007 to 2019 without restrictions. We followed PRISMA 2009 guidelines. The search yielded 3015 hits in total. Following duplicate exclusion, 2674 abstracts were screened and 453 full-texts evaluated based on our pre-defined screening criteria. 149 articles were eligible for inclusion.ResultsWe found that single nucleotide polymorphisms (SNPs) in HNF1B, KLF, EIF2AK, CYP19A1, SOX4 and MYC were strongly associated with incident endometrial cancer. Nineteen variants were reported with genome-wide significance and a further five with suggestive significance. No convincing evidence was found for the widely studied MDM2 variant rs2279744. Publication bias and false discovery rates were noted throughout the literature.ConclusionEndometrial cancer risk may be influenced by SNPs in genes involved in cell survival, oestrogen metabolism and transcriptional control. Larger cohorts are needed to identify more variants with genome-wide significance.
Analgesic efficacy of infiltration between the popliteal artery and capsule of the knee (iPACK) block added to local infiltration analgesia and continuous adductor canal block after total knee arthroplasty: a randomized clinical trial
Authors: Vichainarong Chutikant , Kampitak Wirinaree , Tanavalee Aree , Ngarmukos Srihatach , Songborassamee Nattaporn 
Published: August 2020

BackgroundA combination of motor-sparing analgesia with local infiltration analgesia (LIA) and continuous adductor canal block (CACB) may improve postoperative pain and functional recovery for total knee arthroplasty (TKA). We hypothesized that the addition of a novel technique for posterior knee block, known as the infiltration between the popliteal artery and capsule of the knee (iPACK) block, to LIA with CACB would reduce opioid requirements.MethodsIn this double-blinded randomized controlled trial, 72 patients were assigned to receive either LIA with CACB (LIA+CACB group) or iPACK block with LIA and CACB (iPACK+LIA+CACB group). The primary outcome was cumulative postoperative intravenous morphine consumption within 24 hours. The secondary outcomes included numerical rating scale pain scores, incidence of posterior knee pain, performance test results, patient satisfaction, length of stay, and adverse events.ResultsMorphine consumption within 24 hours postoperatively showed no significant intergroup difference (LIA+CACB; 1.31±1.85 mg vs iPACK+LIA+CACB; 0.61±1.25 mg, p=0.08). There were no clinically significant differences in the overall pain scores between the groups. The lower Timed Up and Go test scores on postoperative days 1 and 2, along with a shorter duration of hospitalization, were found in the iPACK+LIA+CACB group (p<0.05).ConclusionThe addition of an iPACK block to the LIA and CACB does not reduce the postoperative opioid consumption nor improve analgesia. However, it may improve immediate functional performance and reduce the length of hospitalization after TKA.Trial registration numberTCTR20180702001.
Protective effect of club cell secretory protein (CC-16) on COPD risk and progression: a Mendelian randomisation study
Authors: Milne Stephen , Li Xuan , Hernandez Cordero Ana I , Yang Chen Xi , Cho Michael H , Beaty Terri H , Ruczinski Ingo , Hansel Nadia N , Bossé Yohan , Brandsma Corry-Anke , Sin Don D , Obeidat Maen 
Published: August 2020

BackgroundThe anti-inflammatory pneumoprotein club cell secretory protein-16 (CC-16) is associated with the clinical expression of chronic obstructive pulmonary disease (COPD). We aimed to determine if there is a causal effect of serum CC-16 level on the risk of having COPD and/or its progression using Mendelian randomisation (MR) analysis.MethodsWe performed a genome-wide association meta-analysis for serum CC-16 in two COPD cohorts (Lung Health Study (LHS), n=3850 and ECLIPSE, n=1702). We then used the CC-16-associated single-nucleotide polymorphisms (SNPs) as instrumental variables in MR analysis to identify a causal effect of serum CC-16 on ‘COPD risk’ (ie, case status in the International COPD Genetics Consortium/UK-Biobank dataset; n=35 735 COPD cases, n=222 076 controls) and ‘COPD progression’ (ie, annual change in forced expiratory volume in 1 s in LHS and ECLIPSE). We also determined the associations between SNPs associated with CC-16 and gene expression using n=1111 lung tissue samples from the Lung Expression Quantitative Trait Locus Study.ResultsWe identified seven SNPs independently associated (p<5×10–8) with serum CC-16 levels; six of these were novel. MR analysis suggested a protective causal effect of increased serum CC-16 on COPD risk (MR estimate (SE) −0.11 (0.04), p=0.008) and progression (LHS only, MR estimate (SE) 7.40 (3.28), p=0.02). Five of the SNPs were also associated with gene expression in lung tissue (at false discovery rate <0.1) of several genes, including the CC-16-encoding geneSCGB1A1.ConclusionWe have identified several novel genetic variants associated with serum CC-16 level in COPD cohorts. These genetic associations suggest a potential causal effect of serum CC-16 on the risk of having COPD and its progression, the biological basis of which warrants further investigation.
Medical management of a penile fracture with presumed pyelonephritis in a juvenile dog
Authors: Petrelli Andrea , Longo Maurizio , Willems Annelies , Liuti Tiziana 
Published: August 2020

SUMMARYA three‐month‐old male entire Bouvier des Flandres was presented for acute onset dysuria, haematuria, lethargy and severe pain on palpation of the penis. Further investigation revealed a parcellar fracture of the cranial separate ossification centre of the os penis and associated urinary tract infection with presumed pyelonephritis. Fluoroscopic retrograde urethrography was performed revealing intermittent urethral obstruction caused by displacement of the cranial bone fragment of the separate ossification centre of the os penis. The urethra was catheterised to realign the fragments and to permit urination and antibiotic treatment was started. The urinary catheter was kept in place for five days. After its removal, normal urination was observed with complete resolution of the clinical signs. Follow‐up radiographs and ultrasound examination confirmed resolution of mechanical obstruction with fusion of part of the separate ossification centre and realignment of the displaced bony fragment.
Inflation with a class of concave inflaton potentials in Randall–Sundrum model
Authors: Loc Ngo Phuc Duc 
Published: August 2020

AbstractWe investigate inflation with a class of concave inflaton potentials of the form $$\sim \phi ^n$$∼ϕn$$(0<n<1)$$(0<n<1) in the Randall–Sundrum model with an infinite extra spatial dimension. We show that this class of models is much more in good agreement with observations compared to the standard inflation. We also find the range of the five-dimensional Planck scale ($$M_5$$M5) and show that large tensor-to-scalar ratios do not eliminate small-field inflation in braneworld cosmology.
Análise faciológica e contexto deposicional do geossítio Bacia Sedimentar de Curitiba, nova seção-tipo para a Formação Guabirotuba
Authors: Vieira Kimberlym Tábata Pesch , Fernandes Luiz Alberto 
Published: August 2020

O geossítio Bacia Sedimentar de Curitiba é um afloramento da Formação Guabirotuba, unidade que preencheu a Bacia de Curitiba, em área urbanizada. O sítio, localizado na região industrial da capital do Paraná, ganhou notoriedade por ser berço das ocorrências fossilíferas da Fauna Guabirotuba, uma das poucas representantes do Paleógeno no país, que permitiu estabelecer a idade relativa para o preenchimento da bacia. A análise faciológica do afloramento teve o objetivo de refinar o conhecimento acerca dos depósitos sedimentares da unidade, almejando contribuir para futuros estudos tafonômicos e paleoambientais. Para tanto, utilizaram-se métodos de análise faciológica em três segmentos representativos do afloramento, nos quais foram reconhecidas fácies sedimentares, elementos arquitetônicos, modificações eodiagenéticas (calcretes) e o contato com o embasamento. A caracterização composicional dos sedimentos foi complementada com análises petrográficas. O contexto deposicional da Formação Guabirotuba foi interpretado como de depósitos de canais e planícies de inundação de rios entrelaçados em sistema fluvial distributário. As associações de areias e cascalhos em barras que preencheram feições acanaladas foram consideradas como correspondentes a porções proximais, em que predominam depósitos de canais amalgamados, com avulsões frequentes. Esses depósitos ocorrem intercalados com associações de lamas, lençóis e lentes arenosas, caracterizadas como depósitos de espraiamentos laterais em porções distais do sistema. Nos cortes que compõem o afloramento foram feitas importantes descobertas fossilíferas nos últimos anos. Esse foi um dos motivos que tornaram a área unidade de conservação protegida por decreto municipal. Considerando-se tais novidades, e o fato de a seção original da Formação Guabirotuba ter sido ocultada pela urbanização, propõe-se designar o afloramento como área-tipo e o conjunto de seções como nova seção-tipo da unidade.
Potential Predictability of the Silk Road Pattern and the Role of SST as Inferred from Seasonal Hindcast Experiments of a Coupled Climate Model
Authors: Li Ronald Kwan Kit , Tam Chi Yung , Lau Ngar Cheung , Sohn Soo Jin , Ahn Joong Bae 
Published: August 2020

AbstractThe Silk Road pattern (SR) is a leading mode of atmospheric circulation over midlatitude Eurasia in boreal summer. Its temporal phase is known to be unpredictable in many models. Previous studies have not reached a clear consensus on the role of sea surface temperature (SST) associated with SR. By comparing seasonal hindcasts from the Pusan National University (PNU) coupled general circulation model with reanalysis, we investigate if there are any sources of predictability originating from the SST. It was found that the PNU model cannot predict SR temporally. In fact, SR is associated with El Niño–Southern Oscillation (ENSO) in the model hindcasts, in contrast to reanalysis results in which SR is more associated with North Atlantic SST anomalies. The PNU system, however, shows potential predictability in SR associated with tropical Pacific SST. Bias in stationary Rossby waveguides is proposed as an explanation for the SR–ENSO relationship in hindcast runs. Model upper-level wind bias in the North Atlantic results in a less continuous waveguide connecting the North Atlantic to Asia, and may hinder wave propagations induced by North Atlantic SST to trigger SR. On the other hand, model upper-level wind bias in the subtropical western Pacific may favor westward propagation of zonally elongated waves from the ENSO region to trigger SR. This study implies that the role of SST with regard to SR can be substantially changed depending on the fidelity of model upper-level background winds.
Rapid Destruction of a Stratospheric Potential Vorticity Anomaly by Convectively Induced Inertial Instability during the Southern Wisconsin Extreme Flooding Event of 20 August 2018
Authors: Rowe Shellie M. , Hitchman Matthew H. 
Published: August 2020

AbstractThe stalling and rapid destruction of a potential vorticity (PV) anomaly in the upper troposphere–lower stratosphere (UTLS) by convectively detrained inertially unstable air is described. On 20 August 2018, 10–15 in. (~0.3–0.4 m) of rain fell on western Dane County, Wisconsin, primarily during 0100–0300 UTC 21 August (1900–2100 CDT 20 August), leading to extreme local flooding. Dynamical aspects are investigated using the University of Wisconsin Nonhydrostratic Modeling System (UWNMS). Results are compared with available radiosonde, radar, total rainfall estimates, satellite infrared, and high-resolution European Centre for Medium-Range Weather Forecasts (ECMWF) operational analyses. Using ECMWF analyses, the formation of the UTLS PV anomaly is traced to its origin a week earlier in a PV streamer over the west coast of North America. The rainfall maximum over southern Wisconsin was associated with this PV anomaly, whereby convection forming in the warm-upglide sector rotated cyclonically into the region. The quasi-stationarity of this rainfall feature was aided by a broad northeastward surge of inertially unstable convective outflow air into southeastern Wisconsin, which coincided with stalling of the eastward progression of the PV anomaly and its diversion into southern Wisconsin, extending heavy rainfall for several hours. Cessation of rainfall coincided with dilution of the PV maximum in less than an hour (2100–2200 CDT), associated with the arrival of negative PV in the upper troposphere. The region of negative PV was created when convection over Illinois transported air with low wind speed into northeastward shear. This feature is diagnosed using the convective momentum transport hypothesis.
Change of poverty and outcome of persons with severe mental illness in rural China, 1994-2015
Authors: Zhao Xinyi , Yu Yue-Hui , Peng Man-Man , Luo Wei , Hu Shi-Hui , Yang Xin , Liu Bo , Zhang Tin , Gao Ru , Chan Cecilia Lai-Wan , Ran Mao-Sheng 
Published: August 2020

Background: It is unknown whether and how poverty influences the long-term outcome of persons with severe mental illness (SMI). Aims: To explore the change of poverty status in persons with SMI from 1994 to 2015 and examine the impact of poverty status on patients’ outcome in rural China. Method: Two mental health surveys using identical methods and International Classification of Disease (ICD-10) were conducted in 1994 and 2015 in the same six townships of Xinjin County, Chengdu, China. Results: The annual net income per person was 19.8% and 100.2% higher for the general population than for persons with SMI in 1994 and 2015 respectively. Compared with 1994 (48.2%), persons with SMI in 2015 had significantly higher rates of poor family economic status (<mean) (65.2%) ( p < .001). Persons with SMI in poor family economic status were significantly more likely to be male, unmarried, unable to work, with no family caregivers or a smaller number of family members, and in poor mental status in 1994 and 2015 (p < .05). The risk factors significantly associated with patients’ poor mental status included poor work ability, younger age of first onset, never-treated status and poor family economic status. Conclusions: Relative poverty of persons with SMI has become more severe during the rapid socioeconomic development in rural China. Relative poverty of household, poor work ability, younger age of onset and never-treated status are risk factors of poor outcome. Culture-specific, community-based interventions and targeted poverty alleviation programs should improve patients’ early identification, treatment and recovery.
Computational fluid dynamics assessment for the thermal performance of double-skin façades in office buildings under hot climatic condition
Authors: Kim Daeung Danny 
Published: August 2020

In general, a double-skin façade has been used to reduce energy consumption as well as to improve thermal performance in buildings as a buffer space between indoors and outdoors. The goal of this study is to undertake pre-normative research to provide information for developing a comprehensive double-skin façade system under the climatic condition in Saudi Arabia. To pursue this goal, the characteristics associated with the double-skin façade system are identified. In addition, the impact of various configurations on the thermal performance of the double-skin façades is evaluated under the weather situation in Saudi Arabia. Computational double-skin façade models are created by computational fluid dnamics simulation to assess the thermal performance of the various configurations such as cavity geometry and the use of a shading device. As a result, the variation of the opening size has a significant impact on the temperature in the cavity of the double-skin façade. For the air velocity in the cavity, the variation of the opening size and cavity depth is less sensitive. Moreover, the use of a shading device has an impact on the temperature drop in the cavity of the double-skin façade. Practical application: Generally, many studies have investigated the efficiency of double-skin façade applications due to its beneficial aspects. However, a few buildings have adopted double-skin façades to their envelopes. With a substantial growing demand for building industry in Saudi Arabia, double-skin façade applications to building design can be a solution for reducing building energy consumption. The present study investigates the thermal performance of double-skin façades under hot climates in Saudi Arabia and it can provide information for building stakeholders to develop proper double-skin façade systems