bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Hidrodinamika di Perairan Lemong, Kabupaten Lampung Barat, Provinsi Lampung Menggunakan Piranti Surface-Water Modeling System
Authors: Wurjanto Andojo , Ajiwibowo Harman 
Published: July 2020

Pantai Lemong merupakan bagian dari Kawasan Pantai Pesisir Barat, Provinsi Lampung yang berpotensi terkena abrasi akibat gelombang dari Samudera Hindia. Rencana pengamanan pantai diperlukan untuk mencegah abrasi. Studi ini dilakukan untuk mengidentifikasi karakteristik pasang surut dan arus di perairan Lemong sebagai parameter untuk perencanaan pengaman pantai. Analisis pasang surut dan arus dilakukan dengan pemodelan numerik pada modul RMA2 dari perangkat lunak Surface-Water Modeling System (SMS). Data yang digunakan pada pemodelan adalah batimetri dan elevasi pasang surut setempat yang didapatkan dari hasil survei. Pemodelan dilakukan dengan metode online nesting dengan empat tingkat resolusi grid dengan resolusi tertinggi pada 1 x 1 km2 saat mendekat ke Perairan Pantai Lemong. Hasil pemodelan divalidasi dengan data lapangan berupa elevasi pasang surut pada dua titik di perairan dangkal dan tiga titik di perairan dalam. Hasil pemodelan menunjukkan bahwa tunggang pasang surut di wilayah Pantai Lemong mencapai 1,4 m dengan tipe mixed – dominan semi diurnal. Hasil pemodelan juga menunjukkan pola arus di Perairan Lemong yang memiliki arah dominan menuju Tenggara saat pasang dan menuju Barat Laut saat surut. Untuk pengembangan model berikutnya, disarankan agar menyertakan data kecepatan arus hasil survei lapangan dalam proses validasi sehingga kesesuaian hasil pemodelan dengan lapangan dapat lebih ditingkatkan.Hydrodynamic Analysis Using Surface-water Modeling System in Lemong Waters, West Lampung Regency, Lampung ProvinceLemong Beach is part of the western coast of Lampung Province which is prone to abrasion caused by the Indian Ocean waves. This study aims to identify the tidal and current characteristics in Lemong waters as a part of coastal protection planning. The tidal analysis is performed by using the RMA2 module from Surface-Water Modeling System (SMS). Data utilized in the model including bathymetry and local tidal elevations from field surveys. Modeling is conducted using an online nesting method utilizing four stages of grid resolution with 1 x 1 km2 as the highest used around the Lemong Beach Waters. The model is validated with the tidal elevations measured in two points in shallow water and three points in deep water areas. The modeling result shows that the tidal range of Lemong Beach Waters is approximately 1.4 meters as a mixed tide, dominantly in semi-diurnal. The model also shows that the current pattern in Lemong Beach Waters is dominantly moving towards southeast during flows and towards northwest during ebbs. Modeling can be further improved by including current speed from field measurement in the validation process.
High common childhood illnesses while treatment seeking behavior of mothers’/care givers’ was low at rural northwest Ethiopia
Authors: Kebede Zemene Tigabu , Gelaye Kassahun Alemu , Merid Mehari Woldemariam , Akalu Temesgen Yihunie , Amare Ashenafi Tazebew , Toni Alemayehu Teklu , Bikis Gashaw Andargie , Ayele Tadesse Awoke 
Published: July 2020

Abstract
Background: In most developing countries, childhood illness and deaths are among the most challenging health issues. Most of these deaths were due to preventable causes including acute respiratory infections (ARI), diarrhea, and febrile illnesses. Thus, the identification of determinants of this childhood illness would help to guide strategic planning and prioritize interventions.Method: Community based cross-sectional study was conducted. A two-stage cluster sampling technique was used to select households and mothers/caregivers. A total of 2,158 mothers with at least one under-five child were included. Mothers were interviewed at their homes using structured questionnaire. Adjusted Odds Ratio with a 95% Confidence Interval for variables with P-value <0.05 in the multivariable model were reported to show the significance and the direction of association.Result: The overall prevalence of childhood illnesses was 16.5% (95% CI: 15.0, 18.2). Of all, 6.5% (95% CI: 5.5, 6.72), 7.5% (95% CI: 6.5, 8.76), and 12.0% (95% CI: 10.66, 13.40) had diarrhea, ARI, and fever, respectively. The treatment-seeking behavior of mothers/care-givers for any of the childhood illness was 22.7% (18.72, 27.42). The odds of childhood illness was higher among mothers’ age 15-19 years (AOR=2.87-; 95% CI: 1.33, 6.13), employed mothers’ (AOR=2.28; 95%CI: 1.84, 4.39), living far away from nearest health center (AOR=1.02; 95%CI: 1.01, 1.03), two under-five children (AOR=1.33;95%CI: 1.029,1.74) and three or more children in the house (AOR=2.70; 95%CI: 1.12, 6.53). About 22.8% (95% CI: 18.7, 27.4) of mothers/caregivers sought health care. Mothers’ occupation (AOR= 4.08 (95% CI: 1.35, 12.39) was the only independent predictor of treatment-seeking behavior.Conclusion: In this study, common childhood illnesses remain high while the treatment-seeking behavior of the mothers’/caregivers’ was low. Mothers’ age, occupation, distance from the nearest health center, and two or more children in the house were independent factors of childhood illness. Being a skilled/semi-skilled mothers was significantly associated with health-seeking behavior of mothers/caregivers. Thus, involving women in skilled/semi-skilled occupations would help in decreasing childhood illness and enhance health-seeking behaviors for their under-five children. Besides, providing access to health care facilities in their nearby area would be essential in reducing childhood illness.
The Impact of Supply-side and Demand-side Interventions on Use of Antenatal and Maternal Services in Western Kenya: A Qualitative Study
Authors: Hirai Mitsuaki , Morris Jamae , Luoto Jill , Ouda Rosebel , Atieno Nancy , Quick Robert 
Published: July 2020

Abstract
Background: Antenatal care (ANC) and delivery by skilled providers have been well recognized as effective strategies to prevent maternal and neonatal mortality. ANC and delivery services at health facilities, however, have been underutilized in Kenya. One potential strategy to increase the demand for ANC services is to provide health interventions as incentives for pregnant women. In 2013, an integrated ANC program was implemented in western Kenya to promote ANC visits by addressing both supply- and demand-side factors. Supply-side interventions included nurse training and supplies for obstetric emergencies and neonatal resuscitation. Demand-side interventions included SMS text messages with appointment reminders and educational contents, group education sessions, and vouchers to purchase health products. Methods: To explore pregnant mothers’ experiences with the intervention, ANC visits, and delivery, we conducted focus group discussions (FGDs) at pre- and post-intervention. A total of 19 FGDs were held with pregnant mothers, nurses, and community health workers (CHWs) during the two assessment periods. We performed thematic analyses to highlight study participants’ perceptions and experiences. Results: FGD data revealed that pregnant women perceived the risks of home-based delivery, recognized the benefits of facility-based delivery, and were motivated by the incentives to seek care despite barriers to care that included poverty, lack of transport, and poor treatment by nurses. Nurses also perceived the value of incentives to attract women to care but described obstacles to providing health care such as overwork, low pay, inadequate supplies and equipment, and insufficient staff. CHWs identified the utility and limitations of text messages for health education. Conclusions: Future interventions should ensure that adequate workforce, training, and supplies are in place to respond to increased demand for maternal and child health services stimulated by incentive programs.
The incidence of stroke among selected patients undergoing elective posterior lumbar fusion: a retrospective cohort study
Authors: Arena Patrick J , Mo Jingping , Sabharwal Charu , Begier Elizabeth , Zhou Xiaofeng , Gurtman Alejandra , Liu Qing , Shen Rongjun , Wentworth Charles , Huang Kui 
Published: July 2020

Abstract
Background: Although stroke is a rare complication among spinal surgery patients, the recognition of this adverse event is critical given the aging population undergoing surgical procedures. The objective of this study was to estimate the incidence of stroke among selected adults undergoing elective posterior lumbar fusion (PLF) during various post-operative risk windows and among different subgroups. Methods: A retrospective cohort study using a longitudinal electronic healthcare record (EHR) database was conducted from January 1, 2007 to June 30, 2018. Elective PLF, stroke, and select clinical characteristics were defined based on International Classification of Disease codes. Patients aged 18 to 85 years with ≥ 183 days of enrollment in the database prior to undergoing elective PLF were followed from the index date until the occurrence of stroke, death, loss to follow-up, or end of study period, whichever occurred first. The incidence of stroke was estimated in the following risk windows: index hospitalization, ≤ 30 days, ≤ 90 days, ≤ 180 days, and ≤ 365 days post-operation Results: A total of 43,063 patients were eligible for the study. The incidence of stroke following elective PLF was 0.29% (95% confidence interval [CI]: 0.25%, 0.35%) during index hospitalization, 0.44% (95% CI: 0.38%, 0.50%) ≤ 30 days, 0.59% (95% CI: 0.52%, 0.67%) ≤ 90 days, 0.76% (95% CI: 0.68%, 0.85%) ≤ 180 days, and 1.12% (95% CI: 1.03%, 1.23%) ≤ 365 days post-operation. Stratified analyses revealed that older patients had a higher incidence of stroke. Additionally, black patients had higher stroke incidences. Post-operative stroke incidence was higher among patients with a history of type 2 diabetes than among patients without such history; similarly, stroke incidence was higher among patients with a history of stroke compared to patients without such history. Conclusions: The incidence of stroke following elective PLF using an EHR database in this study is slightly higher than that reported in the literature. Our results suggest that stroke risk modification prior to PLF may be important for patients who are older, black, type 2 diabetic, and/or have a history of stroke.
Challenges and prospects for implementation of community health volunteers’ digital health solutions in Kenya: a qualitative study
Authors: Bakibinga Pauline , Kamande Eva , Kisia Lyagamula , Omuya Milka , Matanda Dennis J , Kyobutungi Catherine 
Published: July 2020

Abstract
Background: The value of digital health technologies in delivering vital health care interventions, especially in low resource settings is increasingly appreciated. We co-developed and tested a decision support mobile health (m-Health) application (app); an integrated data capture tool running as a mobile app with selected reporting forms for Community Health Volunteers (CHVs) in Kenya and connected to health facilities. This paper explores the experiences of CHVs, health workers and members of Sub-County Health Management Teams following implementation of the project.Methods: Data were collected in December 2017 through in-depth interviews and focus group discussions with CHVs, and key informant interviews with health care workers and health managers in Kamukunji sub-County of Nairobi, Kenya. Data coding and analysis was performed in NVivo 12.Results: Regarding users and health managers’ perceptions towards the system; three main themes were identified: 1) variations in use, 2) barriers to use and 3) recommendations to improve use. Health workers at the private facility and some CHVs used the system more than health workers at the public facilities. Four sub-themes under barriers to use were socio-political environment, attitudes and behaviour, issues related to the system and poor infrastructure. A prolonged health workers’ strike, the contentious presidential election in the year of implementation, interrupted electricity supply and lack of basic electric fixtures were major barriers to use. Suggestions to improve usage were: 1) integration of the system with others in use and making it available on users’ regular phones, and 2) explore sustainable motivation models to users as well as performance based remuneration. Conclusions: The findings reveal the importance of considering the readiness of information and communication technologies (ICT) users before rollout of ICT solutions. The political and sociocultural environment in which the innovation is to be implemented and integration of new solutions into existing ones is critical for success. As more healthcare delivery models are developed, harnessing the potential of digital technologies, strengthening health systems is critical as this provides the backbone on which such innovations draw support.
Effect and Mechanism of Lycium Barbarum Polysaccharide on Hyperglycemia and Inflammation in Diabetic KKAy Mice
Authors: yin hong , Deng Shuying , Bai Lili , Li Lihua , Liu Tingting , Cai Huizhen 
Published: July 2020

Abstract
Scope

The aim of this study is to examine whether lycium barbarum polysaccharide (LBP) supplementation improves hyperglycemia and inflammation in diabetic KKAy mice.

Methods

The successfully established diabetic KKAy mice are randomized into five groups: diabetic model, metformin, low‐dose LBP, middle‐dose LBP, and high‐dose LBP . C57BL/6J mice are fed a chow diet as normal control . The blood glucose and body weight of mice were measured at different time points. At the end of 90 days, serum inflammatory factors were determined with ELISA kits. The expression of TLR4, MyD88, TRAF6, IκKβ, IκB, P-IκB and nuclear NF-κB proteins in mouse peritoneal macrophages were detected by Western Blotting.

Results

Blood glucose decreased significantly after the intervention among low-, medium-dose LBP groups and Met group ( P <0.05). Met (40 mg/kg) inhibited the levels of IL-1β, TNF-α and IL-6 and elevated IL-10 level ( P <0.05). ELISA results showed that LBP promoted serum levels of IL-10 and decreased TNF-α level ( P <0.05). Compared with model group, KKAy mice in Met group expressed lower protein levels of MyD88, TRAF6, IκKβ, nuclear NF-κB and higher expression of IκB ( P <0.05); The expression of TLR4, MyD88, TRAF6, IκKβ and nuclear NF-κB protein in low- and medium-doses LBP groups were significantly declined ( P <0.05).

Conclusion

These findings indicate that dietary supplementation with LBP can improve hyperglycemia and inflammation in diabetic KKAy mice, which can be associated with potential benefits to human health.
Cost-Utility of Rotator Cuff Repair Surgery by Open and Arthroscopic Techniques: Study Protocol for a Randomized Clinical Trial
Authors: PIERAMI RAFAEL , Antonioli Eliane , Oliveira Isadora , Castro Isabela , Manente Felipe , Fairbanks Paula , Carrera Eduardo , Matsumura Bruno , Lenza Mario 
Published: July 2020

Abstract
Background: Shoulder pain is one of the most common musculoskeletal conditions in orthopedic practice. Rotator cuff injuries account for up to 70% of pain in the shoulder girdle. However, there is still no consensus on the best surgical treatment of patients with degenerative rotator cuff injuries, considering cost-effectiveness and cost-utility analysis between the open and arthroscopic methods of rotator cuff repair. The objective of this trial is to compare the efficacy, cost-effectiveness and cost-utility of open and arthroscopic procedure for rotator cuff repair. Methods: The trial is a two-group, parallel design, randomized controlled study. A total of 100 patients with symptomatic rotator cuff lesion will be allocated to repair surgery and randomized by either open or arthroscopic technique in a 1:1 ratio, considering smoking (yes or no), lesion size (less than 3 cm or more than 3 cm) and diabetes (present or absent) as stratification factors. All patients will be included in the same rehabilitation program after the intervention. The primary outcome measure will be the Constant-Murley score at 48 weeks post-surgery. Secondary outcomes include cost-effectiveness, cost-utility, pain, complications and clinical analysis, using the EuroQol 5-D3L, the simple shoulder test (SST), Visual Analogue Pain Scale (VAS), integrity of the repair evaluated through magnetic resonance imaging, complications and failures of the proposed methods. Theses outcomes will also be measured continuously for 48 weeks after the intervention. For the cost-effectiveness analyses, we will use the VAS and the Constant-Murley Score as measures of effectiveness; for the cost-utility analyses, we will use the EuroQol- 5D-3L as a measure of utility in terms of incremental cost per quality-adjusted life-years (QALY). Discussion: There are two options of the rotator cuff repair surgery, open and arthroscopic and, both procedure present good clinical results. However, considering that the arthroscopic surgery present supposedly higher costs, is necessary to understand if these costs present a best cost-effectiveness and cost-utility for the patient.Trials registration: ClinicalTrials.gov register: NCT04146987. Registered October 31, 2019
Candida prevalence and oral hygiene due to orthodontic therapy with conventional brackets
Authors: Grzegocka Kinga , Krzyściak Paweł , Hille-Padalis Anna , Loster Jolanta E. , Talaga-Ćwiertnia Katarzyna , Loster Bartłomiej W. 
Published: July 2020

Abstract
Background: Conventional brackets are often used during orthodontic therapy of patients with malocclusion. T heir complicated construction greatly inhibits oral hygiene, which predisposes to increased carriage of microbiota. Orthodontic brackets could be a reservoir of yeast and predispose to oral candidosis.Objectives: The aim of this study was to assess Candida prevalence and role of oral hygiene during fixed appliance therapy. Further aim was to characterize isolated yeasts according to their ability to biofilm formation.Methods: Seventeen participants (average age 17 ± 7 years) were monitored by taking oral rinses, elastomeric ligatures samples and evaluation of Approximal Plaque Index (API) and Gingival Bleeding Index (GBI) before and after placement of orthodontic conventional brackets for 12 weeks. Isolated yeasts w ere counted and biofilm formation was evaluated.Results: One hundred and sixteen samples (67 oral rinses and 49 orthodontic elastomers) were collected. Ten patients (58.8% subjects) were Candida-carriers (2 were colonized after bracket placement) and C. albicans was the most common species. The average number of yeasts in the oral cavity showed some fluctuation during the study but in general with an upward trend (adj. R2 = 0.7967, p = 0.07025). The correlation of median number of yeasts with periodontal indexes (API, GBI) was found. I n Candida-carries average API values decreased (adj. R 2 = 0.95; p = 0.01709), while in non- Candida -carriers average GBI values increased (adj. R 2 = 0.92; p = 0.0256).Conclusions: Treatment with orthodontic appliances promotes Candida yeast colonization which is variable over time in terms of strain and species, with domination of C. albicans, without an increased biofilm-forming activity. In carriers, the API value decreases over time, and in non-colonized patients the GBI value increases – which may have a predictive significance for the development of oral candidiasis during orthodontic treatment.
LncRNA SNHG10 is downregulated in non-small cell lung cancer and predicts poor survival
Authors: Liang Meng , Wang Linlin , Cao Chuanhua , Song Shimao , wu feng 
Published: July 2020

Abstract
LncRNA SNHG10 has been characterized as an oncogenic lncRNA in liver cancer. By analyzing TCGA dataset we observed the downregulation of SNHG10 in non-small cell lung cancer (NSCLC), indicating its involvement in this disease. We then analyzed the role of SNHG10 in NSCLC. Tumor and paired non-tumor tissues were harvested from 62 NSCLC patients. The expression of SNHG10 and miR-21 in tissues were determined by RT-qPCR. Overexpression of SNHG10 or miR-21 in NSCLC cells was achieved and the interaction between them was evaluated. Cell proliferation was determined by CCK-8 assay. In this study we found that SNHG10 was downregulated in cancer tissues of NSCLC patients. High expression levels of SNHG10 predicted favorable survival of NSCLC patients. The expression levels of miR-21 were increased in NSCLC and inversely correlated with SNHG10. In NSCLC cells, overexpression of SNHG10 led to increased miR-21 gene methylation and decreased the expression levels of miR-21. In cell proliferation assay, overexpression of SNHG10 attenuated the enhancing effect of overexpression of miR-21 on cell proliferation. SNHG10 was downregulated in non-small cell lung cancer and predicted poor survival. It may downregulate miR-21 through methylation to suppress cancer cell proliferation.
Effects of eradication of Helicobacter pylori on oral malodor and the oral environment: a single-center observational study
Authors: Suzuki Nao , Beppu Richiko , Yoneda Masahiro , Takeshita Toru , Asakawa Mikari , Yamashita Yoshihisa , Hanioka Takashi , Hirofuji Takao , Shinohara Tetsuo 
Published: July 2020

Abstract
Objective: Although a relationship between Helicobacter pylori and oral malodor has been suggested, it remains to be confirmed. One reason for this is that many studies assess oral malodor subjectively. Another reason for the uncertainty is that the reduction in oral malodor may be due to the effect of antibiotics on the oral microbiota. In this study, changes in oral malodor and the eradication treatment of H. pylori were investigated by organoleptic test and gas chromatography. In addition, the salivary bacterial composition and clinical parameters were analyzed.Results: The organoleptic test score, hydrogen sulfide and dimethyl sulfide concentrations, and all clinical parameters except for tongue-coating score were significantly decreased at 1 week compared with baseline. Although antibiotic treatment also altered the overall composition of the salivary bacterial population, it had recovered at 7 weeks. On the date that H. pylori was determined to have been eradicated from all of the subjects (7 weeks after treatment), only the organoleptic test score was significantly lower compared with baseline. The hydrogen sulfide and dimethyl sulfide concentrations were non-significantly lower than those at baseline.