bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of facial expression on emotional contagion and product evaluation in print advertising
Authors: Isabella Giuliana , Vieira Valter Afonso 
Published: January 2020

Purpose
The purpose of this paper is to investigate the emotional contagion theory in print ads, and expand the literature of smiling to different type of smiles and gender congruency. Emotional contagion happens when an emotion is transferred from a sender to a receiver by the synchronization of emotions from the emitter. Drawing on emotional contagion theory, the authors expand this concept and propose that smiles in static facial expressions influence product evaluation. They suggest that false smiles do not have the same impact as genuine smiles on product evaluation, and the congruence between the model gender–product in a static ad and the gender of the viewer moderates the effects.

Design/methodology/approach
In Experiment 1, subjects were randomly assigned to view one of the two ad treatments to guard against systematic error (e.g. bias). In Experiment 2, it was investigated whether viewing a static ad featuring a model with a false smile can result in a positive product evaluation as was the case with genuine smiles (H3). In Experiment 3, it was assumed that when consumers evaluate an ad featuring a smiling face, the facial expression influences product evaluation, and this influence is moderated by the congruence between the gender of the ad viewer and the product H gender of the model in the ad.

Findings
Across three experiments, the authors found that the model’s facial expression influenced the product evaluation. Second, they supported the association between a model’s facial expression and mimicry synchronization. Third, they showed that genuine smiles have a higher impact on product evaluation than false smiles. This novel result enlarges the research on genuine smiles to include false smiles. Fourth, the authors supported the gender–product congruence effect in that the gender of the ad’s reader and the model have a moderating effect on the relationship between the model’s facial expression and the reader’s product evaluation.

Originality/value
Marketing managers would benefit from understanding that genuine smiles can encourage positive emotions on the part of consumers via emotional contagion, which would be very useful to create a positive effect on products. The authors improved upon previous psychological theory (Gunnery et al., 2013; Hennig-Thurau et al., 2006) showing that a genuine smile results in higher evaluation scores of products presented in static ads. The theoretical explanation for this effect is the genuine smile, which involves contraction of both zygomatic major and orbicularis oculi muscles. These facial muscles can be better perceived and transmit positive emotions (Hennig-Thurau et al., 2006).
An inkjet‐printed sulfonephthalein dye indicator array for volatile amine detection
Authors: Luo Xiaoyu , Lim Loong‐Tak 
Published: January 2020

AbstractColorimetric indicators are versatile for applications such as intelligent food packaging, for reflecting the actual quality and/or monitoring distribution history of food products. In this study, a colorimetric indicator array composed of sulfonephthalein dyes was successfully developed by piezoelectric inkjet printing, for the detection of volatile amines—the primary spoilage gases for fish and seafood products. The printing inks were formulated in water/ethanol/1‐butanol mixture. By refilling the printer's cartridges with our formulated inks and controlling the red, green, and blue color parameters, a 7 × 9 indicator array was printed onto inkjet transparency films. The color response of the indicator array was tested with different volatile amines at various concentrations. The array indicator was capable of discriminating six different volatile amines: ammonia, trimethylamine, dimethylamine, triethylamine, piperidine, and hydrazine. The printability of the inks was investigated by characterizing their density, surface tension, and dynamic viscosity, dictating that all formulated inks were printable fluid. The microstructural morphologies of the printed dyes on transparency films were evaluated using scanning electron microscopy. Interactions of the dye with the volatiles were studied by Fourier transform infrared spectroscopy. In summary, the piezoelectric inkjet printing method presented in this study offers a convenient, efficient, and flexible means to fabricate colorimetric indicators for detecting food spoilage volatiles. These indicators are promising as sensing components in intelligent packaging systems, to reveal the freshness of fish products by correlating with quality parameters such as total volatile basic nitrogen, microbial growth, and sensory attributes. Further studies on the feasibility of using the array indicators in real food packaging systems, development of strategy to mitigate the potential migration of the indicator dyes, and designing array patterns optimal for machine/human interpretation, are important to commercialize the technology.Practical ApplicationPiezoelectric inkjet printing offers a convenient way to fabricate sensing materials and aligns with industrial packaging operations. The use of indicators on food package helps consumers more accurately perceive real‐time food quality information.
Treatment outcome and clinical characteristics of HER2 mutated advanced non‐small cell lung cancer patients in China
Authors: Xu Fei , Yang Guangjian , Xu Haiyan , Yang Lu , Qiu Weini , Wang Yan 
Published: January 2020

AbstractBackgroundHER2 mutation is found in 1%–2% of lung cancer patients. Studies comparing chemotherapy to HER2‐TKIs are limited. This study aimed to investigate the molecular and clinical patterns of HER2 mutations in advanced non‐small cell lung cancer (NSCLC), and compare the different outcomes between chemotherapy and HER2‐TKIs.MethodsAdvanced or recurrent non‐small cell lung cancer patients with de novo HER2 mutations (N = 75) were included in this study. Molecular information, clinical features, and treatment outcomes were retrospectively collected from a web‐based patient registry and hospital chart review.ResultsBetween October 2012 and December 2018, 65 patients with in‐frame insertion mutations, eight with point mutations and two with gene amplification were found. The most common subtypes of insertion mutations were A775_G776insYVMA, G776delinsVC, and V777_G778insGSP. HER2 mutated patients were mostly young‐aged, females, never or light smokers, with adenocarcinoma. Chemotherapy achieved better outcomes than HER2‐TKIs (median PFS: 5.5 vs. 3.7 months in the first‐line setting and 4.2 vs. 2.0 months in the second‐line setting, P = 0.001 and 0.031, respectively). In particular for the most common subtype, YVMA insertions, PFS was significantly longer in chemotherapy than HER2‐TKIs both in the first‐line (6.0 vs. 2.6 months, P = 0.008) and the second‐line (4.2 vs. 2.6 months P < 0.001).ConclusionsHER2 mutated lung cancer patients were younger, mostly females, never or light smokers, with histologically diagnosed adenocarcinomas. Compared with afatinib, chemotherapy might bring more benefit to HER2 mutated advanced lung cancer patients, especially the most common type of HER2 exon 20 insertions, A775_G776insYVMA subtype.Key pointsChemotherapy achieved better outcomes than afatinib for Chinese HER2 mutated advanced NSCLC patients, especially for the most common subtype, YVMA insertions.
Effect of age on the relative efficacy of clozapine in schizophrenia
Authors: Jones R. , MacCabe J.H. , Price M.J. , Liu X. , Upthegrove R. 
Published: January 2020

ObjectiveEarly treatment of schizophrenia improves outcomes. Clozapine appears to have unique benefit when other antipsychotic medication has failed. This systematic review and meta‐analysis aims to assess clozapine’s superiority over alternative antipsychotic medication and examine whether earlier use is associated with additional benefit.MethodSystematic retrieval of blinded, randomized controlled trials comparing clozapine with alternative antipsychotics in adults with schizophrenia. The effect of mean age on relative clozapine response was examined using random effects meta‐regression, and multiple linear regression on available patient data.ResultsA total of 276 studies were retrieved. Thirty‐four studies were included in the meta‐analysis. Clozapine was significantly more effective than alternative antipsychotics in reducing psychotic symptoms and increasing response. However, meta‐regression failed to show a more significant effect in younger patients (age on effect size (total psychotic symptoms) 0.00,P = 0.79 CI −0.03 to 0.03). Individual patient data were available for two studies, the larger of which showed a significant interaction between younger age and superiority of clozapine.ConclusionThe results support clozapine’s superiority over other antipsychotics. A convincing effect of age on this effect was not demonstrated, although this was suggested in one study. In view of the age of many of the included studies, and changes in reporting practice over time, new clozapine RCTs, which include age of illness onset as well as age at trial time, would be welcome in order to provide meta‐analysable data for future use.
Aberrant reward prediction errors in young adult at‐risk alcohol users
Authors: Cao Zhipeng , Bennett Marc , O'Halloran Laura , Pragulbickaite Gabija , Flanagan Luke , McHugh Louise , Whelan Robert 
Published: January 2020

AbstractPrevious studies suggest that individuals with substance use disorder have abnormally large responses to unexpected outcomes (reward prediction errors [RPEs]). However, there is much less information on RPE in individuals at risk of alcohol misuse, prior to neurobiological adaptations that might result from sustained alcohol use. Here, participants (mean age 23.77 years, range 18‐32 years) performed the electrophysiological monetary incentive delay task. This task involved responding to a target stimulus following reward incentive cues to win, or avoid losing, the cued reward while brain activity was recorded under 64‐channel EEG. The Alcohol Use Disorders Identification Test (AUDIT) was used to quantify at‐risk alcohol use, with high (n = 22, mean AUDIT score: 13.82) and low (n = 22, mean AUDIT score: 5.77) alcohol use groups. Trial‐by‐trial RPEs were estimated using a Rescorla‐Wagner reinforcement model based on behavioral data. A single‐trial analysis revealed that the feedback‐related negativity (FRN) and feedback P3 (fb‐P3) event‐related potential components were significantly modulated by RPEs. There was increased RPE‐related fb‐P3 amplitude for those in the high alcohol use group. Next, the mean amplitude of ERPs elicited by positive and negative RPEs were compared between groups. We found that high alcohol use participants had attenuated FRN amplitude in contrast with low alcohol use participants for both positive and negative RPEs but enhanced fb‐P3 for both positive and negative RPE. These results, with differences in RPE in an at‐risk group, suggest that RPE a potential vulnerability marker for alcohol use disorder.
Discovery of a new nucleotide substitution in the MC1R gene and haplotype distribution in native and non‐Japanese chicken breeds
Authors: Kabir M. H. , Takenouchi A. , Haqani M. I. , Nakamura Y. , Takeuchi S. , Tsudzuki M. 
Published: January 2020

SummaryMelanocortin 1‐receptor (MC1R) is one of the major genes that controls chicken plumage colour. In this study, we investigated the sequence and haplotype distribution of the MC1R gene in native Japanese chickens, along with non‐Japanese chicken breeds. In total, 732 and 155 chickens from 30 Japanese and eight non‐Japanese breeds respectively were used. Three synonymous and 11 non‐synonymous nucleotide substitutions were detected, resulting in 15 haplotypes (H0–H14). Of these, three were newly found haplotypes (H9, H13 and H14), of which one (H9) was composed of known substitutions C69T, T212C, G274A and G636A. The second one (H13) possessed newly found non‐synonymous substitution C919G, apart from the known substitutions C69T, G178A, G274A, G636A and T637C. The third one (H14) comprised a newly discovered substitution C919G in addition to the known C69T, G274A and G409A substitutions. The homozygote for this new haplotype exhibited wt like plumage despite the presence of G274A. In addition to discovering a new nucleotide substitution (C919G) and three new haplotypes, we defined the plumage colour of the bird that was homozygous for the A644C substitution (H5 haplotype) as wheaten‐like for the first time; although the substitution has been already reported, its effect was not revealed. Besides detecting the new plumage colour, we also confirmed that the A427G and G274A substitutions contribute in expressing brownish and black plumage colour respectively, as reported by the previous studies. Moreover, we confirmed that the buttercup allele does not express black plumage despite possessing a G274A substitution, under the suppression effect of A644C. In contrast, the birds homozygous for the birchen allele presented solid black plumage, which was contradictory to the previous reports. In conclusion, we revealed a large diversity in the MC1R gene of native Japanese chicken breeds, along with the discovery of a new non‐synonymous nucleotide substitution (C919G) and three novel haplotypes (H9, H13 and H14).
NotJustParticipation: The Rise of the Eco‐Precariat in the Green Economy
Authors: Neimark Benjamin , Mahanty Sango , Dressler Wolfram , Hicks Christina 
Published: January 2020

AbstractDespite recent attention to “frontier” green economies and the governance of emerging ecosystem services, the specific division of labour in these economies has been little studied. As many such initiatives are in the global South, labour’s marginality potentially contributes to the existing precariousness of those who are more often identified as “participants”. This article examines the roles and vulnerabilities of these actors: the carbon counters, species identifiers, GIS mappers, tree planters and others operating in the shadows. We draw on current understandings of labour and precarity to examine the geographical contours of an apparent and emerging “eco‐precariat”: a socio‐economically diverse group of labourers that address the volatile demands of an ever‐expanding environmental service‐based economy. We illustrate our analysis drawing on examples from a Blue Carbon project in Kenya, ecosystem services project in the Philippines, and REDD+ scheme in Cambodia. We use these examples to theorise the nature of labour in these frontier economies and put forward a framework for analysing the eco‐precariat. We highlight the need to understand the precarity and marginalisation potentially created by this green division of labour in the provision of new ecosystem products and services. This framework contributes to ongoing analyses of labour as a central part of the green economy discourse and to larger discussions in the geographies of labour literature around the future of work in the global South and beyond.
Organised physical activity during leisure time is associated with more objectively measured physical activity among Swedish adolescents
Authors: Fröberg Andreas , Lindroos Anna‐Karin , Ekblom Örjan , Nyberg Gisela 
Published: January 2020

AbstractAimThe aim of this study was to investigate associations between participation in organised physical activity (PA), such as sport and exercise during leisure time, and objectively measured PA and sedentary time in a large representative sample of Swedish adolescents.MethodsThis study was part of the school‐based cross‐sectional Swedish national dietary survey Riksmaten Adolescents 2016‐17. Data from 3477 adolescents aged 11‐12, 14‐15 and 17‐18 years were used in the analyses. Participation in organised PA and parental education were reported in questionnaires. PA and sedentary time were objectively measured through accelerometry during seven consecutive days.ResultsAdolescents who participated in organised PA had significantly higher total PA (14%, P < .001), more time spent on moderate‐to‐vigorous PA (MVPA) (8 minutes, P < .001) and had less sedentary time (15 minutes, P < .001). Those who participated in organised PA were more likely to reach recommended PA levels. Total PA and MVPA did not differ by parental education among those who participated in organised PA.ConclusionAdolescents who participated in organised PA were more physically active, less sedentary and more likely to reach PA recommendations than those who did not.
Constructing confidence intervals for selected parameters
Authors: Zhao Haibing , Cui Xinping 
Published: January 2020

AbstractIn large‐scale problems, it is common practice to select important parameters by a procedure such as the Benjamini and Hochberg procedure and construct confidence intervals (CIs) for further investigation while the false coverage‐statement rate (FCR) for the CIs is controlled at a desired level. Although the well‐known BY CIs control the FCR, they are uniformly inflated. In this paper, we propose two methods to construct shorter selective CIs. The first method produces shorter CIs by allowing a reduced number of selective CIs. The second method produces shorter CIs by allowing a prefixed proportion of CIs containing the values of uninteresting parameters. We theoretically prove that the proposed CIs are uniformly shorter than BY CIs and control the FCR asymptotically for independent data. Numerical results confirm our theoretical results and show that the proposed CIs still work for correlated data. We illustrate the advantage of the proposed procedures by analyzing the microarray data from a HIV study.
Roflupram exerts neuroprotection via activation of CREB/PGC‐1α signalling in experimental models of Parkinson's disease
Authors: Zhong Jiahong , Dong Wenli , Qin Yunyun , Xie Jinfeng , Xiao Jiao , Xu Jiangping , Wang Haitao 
Published: January 2020

Background and PurposeRoflupram improves cognition and limits neuroinflammation in the brain. However, the beneficial effects of roflupram on Parkinson's disease (PD) remain unknown. Therefore, we aimed to elucidate the pharmacological effects and mechanisms of action of ROF in experimental models of PD.Experimental ApproachWe used an in vitro PD model of SH‐SY5Y cells exposed to 1‐methyl‐4‐phenylpyridinium iodide (MPP+). Cell viability and apoptosis were analysed via the MTT assay and flow cytometry. Mitochondrial morphology, mitochondrial respiratory capacity, and ROS were measured by a mitochondrial tracker, Seahorse Analyzer, and a MitoSOX‐Red dye. For in vivo PD model, behavioural tests, Nissl staining, and immunohistochemistry were used to evaluate protection by roflupram. The levels of TH, cAMP response element‐binding protein (CREB), and PPARγ coactivator‐1α (PGC‐1α) were analysed by western blotting.Key ResultsRoflupram decreased MPP+‐induced apoptosis in SH‐SY5Y cells and human dopaminergic neurons. Roflupram also increased mitochondrial respiratory capacity, decreased ROS production, and restored mitochondrial morphology. Roflupram reversed the MPP+‐induced reductions of phosphorylated CREB, PGC‐1α and TH. These protective effects were blocked by the PKA inhibitor H‐89 or by PGC‐1α siRNA. In mice treated with MPTP, roflupram significantly improved motor functions. Roflupram prevented both dopaminergic neuronal loss and the reduction of phosphorylated CREB and PGC‐1α in the substantia nigra and striatum.Conclusion and ImplicationsRoflupram protected dopaminergic neurons from apoptosis via the CREB/PGC‐1α pathway in PD models. Hence, roflupram has potential as a protective drug in the treatment of PD.
Overcoming tamoxifen resistance in oestrogen receptor‐positive breast cancer using the novel thiosemicarbazone anti‐cancer agent, DpC
Authors: Maqbool Sundus N. , Lim Syer C. , Park Kyung Chan , Hanif Rumeza , Richardson Des R. , Jansson Patric J. , Kovacevic Zaklina 
Published: January 2020

Background and PurposeBreast cancer is the leading cause of death in women worldwide, with resistance to current therapeutic strategies, including tamoxifen, causing major clinical challenges and leading to more aggressive and metastatic disease. To address this, novel strategies that can inhibit the mechanisms responsible for tamoxifen resistance need to be assessed.Experimental ApproachWe examined the effect of the novel, clinically‐trialled, thiosemicarbazone anti‐cancer agent, DpC, and its potential as a combination therapy with the clinically used estrogen receptor (ER) antagonist, tamoxifen, using both tamoxifen‐resistant and ‐sensitive, human breast cancer cells (MDA‐MB‐453, MDA‐MB‐231 and MCF‐7) in 2D and 3D cell‐culture. Synergy was assessed using the Chou‐Talalay method. The molecular and anti‐proliferative effects of these agents and their combination was examined via Western blot, immunofluorescence and colony formation assays.Key ResultsCombinations of tamoxifen with DpC were highly synergistic, leading to potent inhibition of cell proliferation, colony formation, and ER‐α transcriptional activity. The combination also more efficiently reduced major molecular drivers of proliferation of tamoxifen‐resistant cells, including c‐Myc, cyclin D1, and p‐AKT, while up‐regulating the cell cycle inhibitor, p27, and inhibiting oncogenic phosphorylation of ER‐α at Ser167. Assessing these effects using 3D cell culture further confirmed the greater effects of DpC combined with tamoxifen in reducing ER‐α expression, and that of the proliferation marker, Ki‐67, in both tamoxifen‐sensitive and ‐resistant MCF‐7 spheroids.Conclusions and ImplicationsThese studies demonstrate that the synergistic combination of DpC with tamoxifen could be a promising new therapeutic strategy to overcome tamoxifen resistance in ER‐positive breast cancer.
How early intervention practitioners describe family‐centred practice: A collective broadening of the definition
Authors: Foster Tricia D. , Decker Kalli B. , Vaterlaus J. Mitchell , Belleville Amanda 
Published: January 2020

AbstractBackgroundGiven the importance of families in supporting the health and developmental outcomes of young children, current recommended practices for early intervention services advocate for a family‐centred practice (FCP) approach that recognizes the importance of children's family systems. Though there is consensus in the field on the importance of this approach, there often remains a disconnection between these values and the everyday practice of early intervention practitioners. This study focuses on understanding the ways in which practitioners define FCP as this can provide valuable insight into why these belief–practice disconnections may exist.MethodsEarly intervention practitioners (n = 203; e.g., special education or child development teachers, therapists, audiologists, etc) were surveyed at a statewide early intervention conference. Qualitative content analyses procedures were used to analyse participants' open‐ended responses.ResultsThree themes emerged in the analysis, including the following: (a) FCP is a distinct approach to providing early intervention services; (b) there are specific practices for best implementing FCP; and (b) there are provider qualities that are essential in order to use FCP.ConclusionsPractitioners' definitions of FCP were primarily in line with recommended practices; however, they extend beyond the current definition of FCP in the early intervention literature, suggesting that the way this approach is conceptualized may be collectively broadening within the field. Opportunities, difficulties, and practical implications of this broadening definition are discussed.