bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does health insurance coverage reduce informal payments? Evidence from the “red envelopes” in China
Authors: Liu Ning , Bao Guoxian , He Alex Jingwei 
Published: February 2020

Abstract
Background
Representing a major threat to both equity and efficiency of health systems, the corrupt practice of informal payments is widely found in developing and transition countries. As informal payments are more likely to occur in health systems characterized by a high out-of-pocket payment rate, it is argued that formalized prepaid health insurance programs may help to curb such practice.

Methods
Using panel data from the China Health and Retirement Longitudinal Survey, this study examined the association between changes in health insurance coverage on patient’s behavior proxied with informal payments.

Results
The statistical results reveal that health insurance status in fact increases the probability of patients making informal payments to physicians. However, this association varies among population groups and insurance programs, particularly between social health insurance and private health insurance status.

Conclusions
In a health system characterized by unequal allocation of medical resources, the dual pursuit of cost saving and quality of care may drive patients to make informal payments for personal gains. This study argues that health policy interventions aimed at curbing informal payments must be based on a thorough understanding of their complex socioeconomic causes and attack the perverse incentives in a coherent and bona fide manner.
Understanding sexual and reproductive health needs of young women living in Zika affected regions: a qualitative study in northeastern Brazil
Authors: Diniz Debora , Ali Moazzam , Ambrogi Ilana , Brito Luciana 
Published: February 2020

Abstract
Background
In 2016, the World Health Organization declared a Public Health Emergency of International Concern due to Zika’s association with microcephaly and other neurological disorders. Brazil was the epicenter of this epidemic and the most affected region has the lowest Human Development Index and the highest rates of adolescent pregnancy. Despite the end of the epidemic, Brazil continues to be the epicenter of Zika illness. This study examined the barriers faced by young women who seek sexual and reproductive health (SRH) care services living in affected areas and their attitudes towards SRH needs and the available services.

Methods
Individual semi-structured interviews were conducted with 22 young women, aged 14–24 years in three Zika affected municipalities in the Brazilian Northeast. This qualitative research used thematic analysis for data analysis.

Results
Almost half (n = 10) of the participants had their first pregnancy during adolescence (from 12 to 19), all of which were unintended. Lack of information and barriers to access family planning were found to contribute to the unmet need for contraception. Participants reported knowledge gaps about contraception. Zika was not considered a health concern and participants were unaware of the possibility of Zika’s sexual transmission.

Conclusions
The young women’s knowledge and attitudes towards their SRH needs highlight the barriers to access care. It also implies that comprehensive, biopsychosocial and political, understanding is necessary in order to adequately provide SRH to this population and meet their needs. The government should place women at the center of any public health response to an emergency affecting women of reproductive age and focus on improving access to information and family planning services in a culturally and age appropriate manner.
Prenatal diagnosis of maternal partial trisomy 9p23p24.3 and 14q11.2q21.3 in a fetus: a case report
Authors: Wu J. B. , Sha J. , Zhai J. F. , Liu Y. , Zhang B. 
Published: February 2020

Abstract
Objective
This study aimed to report a fetus with maternal partial trisomy 9p and 14q and the phenotype detected in ultrasound.

Methods
The chromosome rearrangements in the fetus were characterized by G-banding and chromosome microarray analysis based on single nucleotide polymorphism (SNP) array of cultured amniocytes and compared with the parents’ karyotypes.

Results
The fetal abnormal karyotype was 47,XY,+der(14)(9;14)(p23;q22). The SNP array revealed a duplicate 11.8-Mb 9p23-p24.3 fragment and a duplicate 29.6-Mb 14q11.2-q21.3 fragment. The peripheral blood karyotype of the mother was 46,XX,t(9;14)(p23;q22), while the father’s was normal at the level of 300~400 bands. A high-resolution karyotype analysis conformed the same abnormality of the mother at the level of 550~650 bands. These results indicated that the fetal chromosomal abnormality probably derived from the mother. The fetal nuchal translucency thickness was 3.5 mm, and the fetal heart was detected with around 1.0-mm ventricular defect by the ultrasound examination at 12-week gestation. The couple decided to terminate the pregnancy. They opted for in vitro fertilization and embryo transfer for the fourth pregnancy, which was successful.

Conclusions
The SNP array combined with cytogenetic analysis was particularly effective in identifying abnormal chromosomal rearrangements. These methods combined with the existing database information and fetal ultrasonography might provide a comprehensive and efficient way for the prenatal assessment of fetal situations. Preimplantation genetic diagnosis might effectively assist those women with an adverse pregnancy history in their next pregnancy.
The perspective on standardisation and harmonisation: the viewpoint of the EASI president
Authors: Damoiseaux Jan 
Published: February 2020

AbstractStandardisation of immuno-assays for autoantibodies is a major challenge. Although multiple organisations participate in the generation of internationally accepted standards, adequate standardisation of assays has not yet been achieved. Harmonisation may offer an alternative approach to better align requesting, testing, reporting and interpretation of autoimmune diagnostics. The European Autoimmunity Standardisation Initiative (EASI) was founded to facilitate both standardisation as well as harmonisation of autoantibody tests, but over the years the focus has drifted away from standardisation in favour of harmonisation. In the current paper the options for harmonisation are highlighted.
Characterization of tea leaf metabolites dependent on tea (Camellia sinensis) plant age through 1H NMR-based metabolomics
Authors: Rubel Mozumder N. H. M. , Lee Yeong-Ran , Hwang Kyeong Hwan , Lee Min-Seuk , Kim Eun-Hee , Hong Young-Shick 
Published: February 2020

AbstractThe chemical or metabolic compositions of tea (Camellia sinensis) varies according to numerous factors, such as geographical origin, cultivar, climate, plucking position, and horticultural practices. However, how the age of tea plants affects the metabolite compositions of tea leaves has not been reported yet. Therefore, we extended the metabolomic approach to the investigation of the age-related differences of tea leaf metabolites in the fresh leaves collected from tea plants aged 8 and 25 years. Multivariate statistical analysis with comprehensive metabolite profiles analyzed by 1H NMR spectroscopy showed the clear metabolic differentiation between the fresh tea leaves from different ages of the tea plants. Of the various tea leaf metabolites varied according to the age of the tea plants, theanine, glutamine, catechin, and gallocatechin were uniquely dependent on the age of tea plants, demonstrating a difference of theanine metabolism between young and old tea plants. These results suggest that leaves from 25-year-old tea plants would still be worthy as a functional ingredient for the production in the food or cosmetic industry rather than quality-enhanced tea infusions for human consumption.
Effects of far-off and close-up transition cow feeding on uterine health, postpartum anestrous interval, and reproductive outcomes in pasture-based dairy cows
Authors: Meier S. , Kay J. K. , Kuhn-Sherlock B. , Heiser A. , Mitchell M. D. , Crookenden M. A. , Riboni M. Vailati , Loor J. J. , Roche J. R. 
Published: February 2020

Abstract
Background
In seasonal, pasture-based, dairy production systems, cows must recover from calving and become pregnant within two to 3 months. To achieve this, the uterus must involute and ovulation must occur and continue at regular intervals. As these processes are affected by the cows’ nutritional or metabolic status post-calving, the objective of this study was to evaluate the effect of cow feeding strategies on uterine health, the length of postpartum anestrous interval, and reproductive outcomes. The treatments consisted of two feeding strategies during late-lactation and early dry period (far-off period; starting 4-month pre-calving) and three close-up dry period feeding regimes (1-month pre-calving) in a 2 × 3 factorial arrangement. We randomly assigned 150 cows to one of two far-off treatments. During late lactation, the herds (n = 75 cows per herd) were either control-fed (Controlfed) or over-fed (Overfed) to achieve a low or high body condition score (4-month pre-calving; BCS; ~ 4.25 and ~ 4.75; 10-point scale) at cessation of lactation. Within each of these treatments, three feeding levels were applied during the close-up period (1-month pre-calving): ~ 65% (Feed65), ~ 90% (Feed90), or ~ 120% (Feed120) of metabolizable energy (ME) intakes relative to pre-calving requirements.

Results
Uterine health improved (i.e. polymorphonucleated (PMN) cells declined) with increased feeding during the close-up period for cows in the Overfed group. The reverse was evident for the Controlfed group with the greatest PMN at the highest intakes during the close-up period. The postpartum anoestrous interval (PPAI) was shorter in cows from the Overfed group when moderately fed (Feed90) during the close-up period; in comparison, the PPAI was shorter in the Controlfed group, when those cows were overfed in the close-up period (Feed120). The cows in the Overfed treatment had greater conception and pregnancy rates if cows had moderate dry matter intakes (Feed90) during the close-up period; these reproductive variables were less under excessive feed intakes (Feed120); yet, close-up dry matter intake had little effect on conception and pregnancy rates for the Controlfed group.

Conclusions
The far-off feeding strategies increased early reproductive outcomes at 3 weeks of mating. Additionally, the interaction between far-off and close-up feeding strategies resulted in high six-week pregnancy rate with a slight restriction during the close-up period but only in the far-off Overfed group. Thus, our hypothesis is supported under these conditions.
Explicit measurement of multi-tracer arterial input function for PET imaging using blood sampling spectroscopy
Authors: Velasco Carlos , Mota-Cobián Adriana , Mateo Jesús , España Samuel 
Published: February 2020

Abstract
Background
Conventional PET imaging has usually been limited to a single tracer per scan. We propose a new technique for multi-tracer PET imaging that uses dynamic imaging and multi-tracer compartment modeling including an explicitly derived arterial input function (AIF) for each tracer using blood sampling spectroscopy. For that purpose, at least one of the co-injected tracers must be based on a non-pure positron emitter.

Methods
The proposed technique was validated in vivo by performing cardiac PET/CT studies on three healthy pigs injected with 18FDG (viability) and 68Ga-DOTA (myocardial blood flow and extracellular volume fraction) during the same acquisition. Blood samples were collected during the PET scan, and separated AIF for each tracer was obtained by spectroscopic analysis. A multi-tracer compartment model was applied to the myocardium in order to obtain the distribution of each tracer at the end of the PET scan. Relative activities of both tracers and tracer uptake were obtained and compared with the values obtained by ex vivo analysis of excised myocardial tissue segments.

Results
A high correlation was obtained between multi-tracer PET results, and those obtained from ex vivo analysis (18FDG relative activity: r = 0.95, p < 0.0001; SUV: r = 0.98, p < 0.0001).

Conclusions
The proposed technique allows performing PET scans with two tracers during the same acquisition obtaining separate information for each tracer.
Driving forest succession in karst areas of Chongqing municipality over the past decade
Authors: Xiao Qiang , Xiao Yang , Liu Yuan , Tao Jianping 
Published: February 2020

Abstract
Background
Karst areas in southwestern China exhibit ecological degradation in the form of rocky desertification. Local governments launched large-scale afforestation and other ecological restoration programs to curb this trend. Soil thickness is a key limiting factor for vegetation restoration in Karst areas, but the relationship between ecological restoration and soil thickness remains unclear. Further, afforestation consumes large amounts of water, which impacts water supply in karst areas. In this study, we used GIS and statistical analyses to determine rocky desertification sensitivity and its driving factors in karst areas of Chongqing municipality over the past decade.

Results
Soil thickness is one of the key factors that restrict ecological restoration of rocky desertification. From 2000 to 2010, rocky desertification sensitivity in karst areas was on the rise along with an increase in afforestation. Areas of high sensitivity were mainly distributed in Pengshui County, Wulong District, and Youyang County; Shizhu County had the lowest overall incidence of desertification. Spatial distribution of rocky desertification was significantly affected by rainfall and soil thickness. Regression analysis showed that the main factors controlling changes in rocky desertification in natural forest over time were precipitation which explained 23.73% of total variance, and soil thickness which explained 23.42% of total variance. Soil thickness and soil water content had a higher correlation coefficient (at 0.516) in natural forests than in planted forests.

Conclusion
This study showed that increases in soil thickness in a karst area had a significant positive impact on the fragile ecological environment. This indicates that ecosystem restoration in karst areas will benefit from addressing soil thickness.
A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version)
Authors:   , for the Zhongnan Hospital of Wuhan University Novel Coronavirus Management and Research Team, Evidence-Based Medicine Chapter of China International Exchange and Promotive Association for Medical and Health Care (CPAM), Jin Ying-Hui , Cai Lin , Cheng Zhen-Shun , Cheng Hong , Deng Tong , Fan Yi-Pin , Fang Cheng , Huang Di , Huang Lu-Qi , Huang Qiao , Han Yong , Hu Bo , Hu Fen , Li Bing-Hui , Li Yi-Rong , Liang Ke , Lin Li-Kai , Luo Li-Sha , Ma Jing , Ma Lin-Lu , Peng Zhi-Yong , Pan Yun-Bao , Pan Zhen-Yu , Ren Xue-Qun , Sun Hui-Min , Wang Ying , Wang Yun-Yun , Weng Hong , Wei Chao-Jie , Wu Dong-Fang , Xia Jian , Xiong Yong , Xu Hai-Bo , Yao Xiao-Mei , Yuan Yu-Feng , Ye Tai-Sheng , Zhang Xiao-Chun , Zhang Ying-Wen , Zhang Yin-Gao , Zhang Hua-Min , Zhao Yan , Zhao Ming-Juan , Zi Hao , Zeng Xian-Tao , Wang Yong-Yan , Wang Xing-Huan 
Published: February 2020

AbstractIn December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province; and then named “2019 novel coronavirus (2019-nCoV)” by the World Health Organization (WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development; we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control (including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV.
Increased age at first-mating interacting with herd size or herd productivity decreases longevity and lifetime reproductive efficiency of sows in breeding herds
Authors: Koketsu Yuzo , Iida Ryosuke , Piñeiro Carlos 
Published: February 2020

AbstractBackgroundOur objectives were to characterize sow life and herd-life performance and examine two-way interactions between age at first-mating (AFM) and either herd size or herd productivity groups for the performance of sows. Data contained 146,140 sows in 143 Spanish herds. Sow life days is defined as the number of days from birth to removal, whereas the herd-life days is from AFM date to removal date. Herds were categorized into two herd size groups and two productivity groups based on the respective 75th percentiles of farm means of herd size and the number of piglets weaned per sows per year: large (> 1017 sows) or small-to-mid herds (< 1017 sows), and high productivity (> 26.5 piglets) or ordinary herds (< 26.5 piglets). A two-level liner mixed-effects model was applied to examine AFM, herd size groups, productivity groups and their interactions for sow life or herd-life performance.ResultsNo differences were found between either herd size or herd productivity groups for AFM or the number of parity at removal. However, late AFM was associated with decreased removal parity, herd-life days, herd-life piglets born alive and herd-life annualized piglets weaned, as well as with increased sow life days and herd-life nonproductive days (P < 0.05). Also, significant two-way interactions between AFM and both herd size and productivity groups were found for longevity, prolificacy, fertility and reproductive efficiency of sows. For example, as AFM increased from 190 to 370 days, sows in large herds decreased herd-life days by 156 days, whereas for sows in small-to-mid herds the decrease was only 42 days. Also, for the same AFM increase, sows in large herds had 5 fewer sow life annualized piglets weaned, whereas for sows in small-to-mid herds this sow reproductive efficiency measure was only decreased by 3.5 piglets. Additionally, for ordinary herds, sows in large herds had more herd-life annualized piglets weaned than those in small-to-mid herds (P < 0.05), but no such association was found for high productivity herds (P > 0.10).ConclusionWe recommend decreasing the number of late AFM sows in the herd and also recommend improving longevity and lifetime efficiency of individual sows.
Findings from an exploration of a social network intervention to promote diet quality and health behaviours in older adults with COPD: a feasibility study
Authors: Bloom Ilse , Welch Lindsay , Vassilev Ivaylo , Rogers Anne , Jameson Karen , Cooper Cyrus , Robinson Sian , Baird Janis 
Published: February 2020

Abstract
Background
Diet quality in older people with chronic obstructive pulmonary disease (COPD) is associated with better health and lung function. Social factors, such as social support, social networks and participation in activities, have been linked with diet quality in older age. A social network tool—GENIE (Generating Engagement in Network Involvement)—was implemented in a COPD community care context. The study aimed to assess the feasibility of the GENIE intervention to promote diet quality and other health behaviours in COPD.

Methods
Twenty-two community-dwelling older adults with COPD were recruited from a local COPD service. Participants were offered usual care or the GENIE intervention. Process evaluation methods were used to assess intervention implementation, context and mechanisms of impact; these included observations of patient interactions with the intervention, documented in observational field notes and in films of a patient group discussion. Diet quality was assessed by food frequency questionnaire; ‘prudent’ diet scores were used to describe diet quality at baseline and at 3-month follow-up. Change in diet quality was expressed per month, from baseline to follow-up.

Results
Feasibility data showed that the GENIE intervention could be implemented in this sample of community-living older people. The intervention was acceptable to clinicians and older people with COPD, especially for those with less severe disease, when facilitated appropriately and considering the levels of literacy of participants. There was no significant change in diet quality in the intervention group over the follow-up period (median change in prudent diet score per month (interquartile range (IQR), 0.03 (− 0.24–0.07)), whereas an overall fall in diet quality was observed in the control group (− 0.15 (− 0.24–0.03)).

Conclusion
The process evaluation findings suggest that this intervention is feasible and acceptable to both patients and clinicians. Although the sample size achieved in this study was small, findings suggest that the intervention may have a protective effect against declines in diet quality, and other health behaviours, in an older COPD population. Findings from this feasibility study indicate that further evaluation of the GENIE intervention is warranted in a larger study, with a longer follow-up.

Trial registration
ClinicalTrials.gov, NCT02935452. NIH U.S. National Library of Medicine. Registered 17 October 2016.