bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between obesity and clinical prognosis in patients infected with SARS-CoV-2
Authors: Cai Shao-Hang , Liao Wei , Chen Shu-Wei , Liu Li-Li , Liu Si-Yao , Zheng Zhi-Dan 
Published: June 2020

Abstract
Background
It is well established that obesity is a disease of sustained low-grade inflammation. However, it is currently unknown if obesity plays a role in the clinical manifestations and prognosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients. In this study, we aimed to investigate whether obesity played a role in clinical manifestations and prognosis in patients infected with SARS-CoV-2.

Methods
This is a retrospective multicenter clinical study. A total of 96 patients hospitalized with SARS-CoV-2 infection were enrolled from Dongguan People’s Hospital, Nanfang hospital and the First Affiliated Hospital of Xiamen University between 23 January and 14 February 2020. Demographic and clinical data were extracted from medical records. Acute respiratory distress syndrome (ARDS) was defined as oxygenation index (PaO2/FiO2) ≤ 300 mmHg. We grouped patients through the body mass index (BMI). Associations were examined using the t test, χ2 test and multivariate logistic forward regression test.

Results
Patients with BMI <  24 were significantly younger (P = 0.025) with lower creatine kinase (P = 0.013), lower diastolic pressure blood (P = 0.035), lower serum creatinine (P = 0.012), lower lactate dehydrogenase (P = 0.001) and higher platelet count (P = 0.002). The BMI level was 20.78 ± 3.15 in patients without pneumonia compared with the patients with pneumonia (23.81 ± 3.49, P = 0.001). For patients without ARDS, an average BMI level of 22.65 ± 3.53 was observed, significantly lower than patients with ARDS (24.57 ± 3.59, P = 0.022). The mean BMI was 22.35 ± 3.56 in patients experienced with relieving the clinical symptoms or stable condition by radiographic tests, lower than patients with disease exacerbation with 24.89 ± 3.17 (P = 0.001). In addition, lymphocyte count (r = − 0.23, P = 0.027) and platelet count (r = − 0.44, P < 0.001) were negatively correlated with BMI. While hemoglobin (r = 0.267, P = 0.008), creatine kinase (r = 0.331, P = 0.001), serum creatinine (r = 0.424, P < 0.001) and lactate dehydrogenase (r = 0.343, P = 0.001) were significantly positive correlated with BMI. Multivariate analysis showed that older age (OR = 1.046, P = 0.009) and BMI ≥ 24 (OR = 1.258, P = 0.005) were independent risk factors associated ICU admission while BMI ≥ 24 (OR = 4.219, P = 0.007) was independent risk factor associated with radiographic disease exacerbation.

Conclusions
Our study found BMI was significantly associated with clinical manifestations and prognosis of patients with SARS-CoV-2 infection. For patients with increased risk, clinicians should intervene promptly to avoid disease progression.
The emerging roles of N6-methyladenosine RNA methylation in human cancers
Authors: Shen Huafei , Lan Yifen , Zhao Yanchun , Shi Yuanfei , Jin Jie , Xie Wanzhuo 
Published: June 2020

AbstractN6-methyladenosine (m6A) is the most abundant form of mRNA modification in eukaryotes. It affects various aspects of RNA metabolism, including nuclear export, translation, decay and alternative splicing. In addition, m6A also participates in a great number of human physiological processes, ranging from spermatogenesis modulation, response to heat shock, the control of T cell homeostasis to stem cell proliferation and differentiation. The dynamic equilibrium of m6A level is regulated by m6A methyltransferases (“writers”), m6A demethylases (“erasers”) as well as m6A-binding proteins (“readers”). Once the balance is broken, numerous diseases will knock on the door. Recently, increasing studies reveal that m6A methylation exerts a profound impact on tumorigenesis and tumor progression. Therefore, in this review, we summarize the functions of m6A modification and its emerging roles in human cancers, and discuss the potential of m6A regulators as biomarkers or therapeutic targets.
A hybrid semantic query expansion approach for Arabic information retrieval
Authors: ALMarwi Hiba , Ghurab Mossa , Al-Baltah Ibrahim 
Published: June 2020

AbstractIn fact, most of information retrieval systems retrieve documents based on keywords matching, which are certainly fail at retrieving documents that have similar meaning with syntactical different keywords (form). One of the well-known approaches to overcome this limitation is query expansion (QE). There are several approaches in query expansion field such as statistical approach. This approach depends on term frequency to generate expansion features; nevertheless it does not consider meaning or term dependency. In addition, there are other approaches such as semantic approach which depends on a knowledge base that has a limited number of terms and relations. In this paper, researchers propose a hybrid approach for query expansion which utilizes both statistical and semantic approach. To select the optimal terms for query expansion, researchers propose an effective weighting method based on particle swarm optimization (PSO). A system prototype was implemented as a proof-of-concept, and its accuracy was evaluated. The experimental was carried out based on real dataset. The experimental results confirm that the proposed approach enhances the accuracy of query expansion.
Characterization and field evaluation of tetrahedral and triangular nucleopolyhedrovirus of Spilosoma obliqua (SpobNPV) strain NBAIR1 against jute hairy caterpillar
Authors: Sivakumar G. , Kannan M. , Babu V. Ramesh , Mohan M. , Kumari Surabhi , Rangeshwaran R. , Venkatesan T. , Ballal Chandish R. 
Published: June 2020

AbstractJute hairy caterpillar,Spilosoma(=Spilarctia)obliqua(Walker) (Arctiidae: Lepidoptera), is an irregular and polyphagous insect pest that occurs all over India. A severe natural viral epizootic was observed in the field population ofS. obliquain jute. The virus was characterized asSpilosoma obliquanucleopolyhedrovirus (SpobNPV NBAIR1) based on morphological, biological, and molecular characterization. Under scanning and transmission electron microscopy (SEM and TEM), the occlusion bodies (OBs) of SpobNPV NBAIR1 appeared as both tetrahedral and triangular with the size ranged from 1.04-1.72 μm. The results on the bioassay studies revealed that the lowest LC50value of 2.93 OBs/mm2by leaf disc bioassay against the second instarS. obliquashowed its high virulence. The identity of SpobNPV was further confirmed by the amplification of polyhedrin gene (NCBI GenBank accession no. MK288145). Eleven species of lepidopteran insects, viz.,Spodoptera litura,S. exigua,S. frugiperda,Helicoverpa armigera,Plutella xylostella,Amsacta albistriga,Maruca vitrata,Trichoplusia ni,Pieris brassicae,Agrotis ipsilon, andBombyx mori, were not susceptible to the infection with SpobNPV NBAIR1. Field experiments on jute crop revealed 68.92, 78.59, and 93.16% reduction in larval population ofS. obliquaat 3, 4, and 7 days post spray of SpobNPV NBAIR1 (1.5 × 1012OBs/ha at 2 ml/l), respectively. The present study is a renewed effort in the management ofS. obliquaby the new strain of SpobNPV NBAIR1.
Knowledge of the Egyptian emergency physicians about the use of rt-PA in acute ischemic stroke
Authors: El-khatib Mohamed El-Sayed , El Ahwal Shereen Ahmed , Masoud Muhammad , El Mously Sherine 
Published: June 2020

Abstract
Background
The administration of recombinant tissue plasminogen activator (rt-PA) has increased the focus on acute ischemic stroke (AIS) as an emergency condition. The emergency physicians have to rapidly recognize the patients who are candidates for rt-PA and refer them to the specialized stroke team within the proper time window. The knowledge of the emergency physicians about the benefit and the drawbacks of this therapy is crucial and it affects their attitudes towards its use.

Objective
To apply a survey on the Egyptian emergency physicians aiming to investigate their knowledge about the use rt-PA therapy in AIS.

Methodology
A self-administered questionnaire was sent to the emergency physicians who are working in three Egyptian governorates.

Results
Out of 120 emergency physicians, the total knowledge of the study group was good with a score of 7 ± 1.8/11. Most of the participants mentioned the correct answers (over 50%) for all items except for one question regarding the blood glucose control before the use of rt-PA. Significant positive correlation was noted between the knowledge score and the age.

Conclusions
The surveyed emergency physicians had a good knowledge about the use of rt-PA in AIS, yet, this knowledge is mainly theoretical. Therefore, tutorials, clinical training, and active engagement in the stroke care team are warranted to improve their clinical practice.
Finger millet porridges subjected to different processing conditions showed low glycemic index and variable efficacy on plasma antioxidant capacity of healthy adults
Authors: Kumari Disna , Chandrasekara Anoma , Athukorale Prisko , Shahidi Fereidoon 
Published: June 2020

Abstract
Finger millet porridges (FMP), rich in nutrient and non-nutrient compounds have been used in the traditional food cultures in Asia. The aims of the study were to determine the effect of different processing conditions of finger millet grains on glycemic response, phenolic content and the antioxidant activities of FMP and to determine the short term and long term efficacy of its consumption on plasma antioxidant levels of healthy adults. Twelve types of FMP were prepared combining different processing conditions. Phenolic content of porridges as well as antioxidant activities were determined. The glycemic index (GI) and glycemic load (GL) values of FMP were also evaluated. The long term efficacy of FMP consumption on plasma glucose (PG), total cholesterol (TC) levels and plasma antioxidant capacity (PAC) of 18 subjects were investigated using a 24 weeks randomized cross-over study. The short term efficacy of porridge consumption on AC was determined. PAC was measured by trolox equivalent antioxidant capacity (TEAC) and ferric ion reducing antioxidant power (FRAP). All FMP exhibited low GI values (< 55) except the raw roasted flour which showed high and medium GI values for both particle sizes used. Parboiling of finger millet grains with 15 min steaming produced FMP with low glycemic response and possessed high PAC. Compared to baseline, PAC measured using FRAP and TEAC assays increased after 8 weeks consumption of porridge though significant changes were not observed for PG and TC levels. Furthermore, PAC was increased by 23 and 14% after 2 h of porridge consumption as measured by TEAC and FRAP, respectively. FMP consumption increased the plasma total antioxidant capacity of healthy adults. Further research on examining the potential of FMP on improving the antioxidant capacity in patients with diabetes is warranted.

Graphical abstract
Clinical and methodological considerations for psychological treatment of cognitive impairment in major depressive disorder
Authors: Douglas Katie M. , Milanovic Melissa , Porter Richard J. , Bowie Christopher R. 
Published: June 2020

Background
Cognitive impairment is considered a core feature of major depressive disorder (MDD) and research into psychological treatments aiming to address cognitive impairment are gaining momentum. Compared with the well-established research base of cognitive treatment trials in schizophrenia, including meta-analyses, mood disorder research is much more preliminary.

Aims
To focus on identifying the important factors to consider in developing larger-scale psychological treatment trials targeting cognitive impairment in mood disorders. Trial design recommendations have been published for cognitive treatment trials in bipolar disorder.

Method
An in-depth discussion of methodological considerations in the development of cognitive treatment trials for MDD.

Results
Methodological considerations include: screening for, and defining, cognitive impairment; mood state when cognitive intervention begins; medication monitoring during cognitive interventions; use of concomitant therapy; level of therapist involvement; duration and dose of treatment; choice of specific cognitive training exercises; home practice; improving adherence; appropriate comparison therapies in clinical trials; and choice of primary outcomes.

Conclusions
As well as guidance for clinical trial development, this review may be helpful for clinicians wanting to provide cognitive interventions for individuals with MDD.
A meta-analysis of client-therapist perspectives on the therapeutic alliance: Examining the moderating role of type of measurement and diagnosis
Authors: Igra Libby , Lavidor Michal , Atzil-Slonim Dana , Arnon-Ribenfeld Nitzan , de Jong Steven , Hasson-Ohayon Ilanit 
Published: June 2020

Abstract

Background:
Clients and therapists often have different perspectives on their therapeutic alliance (TA), affecting the process and outcome of therapy. The aim of the present meta-analysis was to assess the mean differences between clients’ and therapists’ estimations of TA among clients with severe disturbances, while focusing on two potential moderators: client diagnosis and alliance instrument.

Method:
We conducted a systematic literature search of studies examining both client perspective and therapist perspective on TA in psychotherapy among people with schizophrenia spectrum disorders, personality disorders, and substance misuse disorders. We then analyzed the data using a random-effects meta-analytic model with Cohen’s d standardized mean effect size.

Results:
Heterogeneity analyses (k = 22, Cohen’s d = −.46, 95% confidence interval = .31–1.1) produced a significant Q-statistic (Q = 94.96) and indicated high heterogeneity, suggesting that moderator analyses were appropriate.

Conclusions:
Our findings show that the type of TA instrument moderates the agreement on TA between client and therapist, but there was no indication of the client’s diagnosis moderating the effect. The agreement between client and therapist estimations seems to be dependent on the instrument that is used to assess TA. Specific setting-related instruments seem to result in higher agreement between clients’ and therapists’ estimations than do more general instruments that are applied to assess TA.
A production and perception study of /t/ glottalization and oral releases following glottals in the US
Authors: Eddington David Ellingson , Brown Earl Kjar 
Published: June 2020

The articulation of /t/ in American English varies according to linguistic and extralinguistic factors. Concerning social factors, word-final /t/ glottalization is seen more among speakers of African American English (Farrington 2018), younger speakers (Partin-Hernandez 2005, Roberts 2006), and women (Byrd 1994, Eddington and Channer 2010).
This paper examines the production and perception of /t/ in five US states: Indiana, Mississippi, New Mexico, Utah, Vermont. For the production study, participants read a letter containing 24 prenasal word-medial /t/s (e.g., kitten) and 28 prevocalic word-final /t/s (e.g., not ever). For the perception study, 22 speakers recorded a unique sentence, each of which was manipulated acoustically in order to yield both oral and nasal releases of prenasal word-medial /t/ (e.g. button [bʌʔən] vs [bʌʔn̩]), as well as tap and glottal stop pronunciations of prevocalic word-final /t/ (e.g. not ever [nɑɾɛvɚ] vs. [nɑʔɛvɚ]). Next, these recordings were presented to participants who rated the speakers in terms of their perceived age, friendliness, pleasantness, rurality, education level, and whether they were from the same state as the participants.
The production results for prenasal word-medial /t/ (e.g. button) indicate that younger speakers produced oral releases more often than their older counterparts. Age also was related to the realization of prevocalic word-final /t/ as a glottal stop (e.g., not ever), such that younger speakers and women produced glottal stops more often than older speakers. In the perception study, speakers who used glottal stops were viewed as less educated and less friendly. Speakers who used oral releases were perceived as more rustic and less educated.
This paper contributes to the literature documenting the production and perception of /t/ in American English and to the literature that demonstrates the usefulness of using both production and perceptual data to study language variation (e.g., Brown 2015).
Cosmopolitanism and Imagination in Nayaka South India
Authors: Gommans Jos 
Published: June 2020

Abstract
Questions arising from the so-called Brooklyn kalamkari, a seven-panel, hand-painted cotton textile, have confronted art historians for decades: what do we see, who produced it for whom, what does it mean? With royal court scenes from all over the Indian Ocean world, the Brooklyn kalamkari represents a uniquely cosmopolitan worldview from early-seventeenth-century South India. In this essay I discuss the makings of this particular worldview in the context of early modern processes of globalization and state-formation. By engaging with the work of Indologists Johan Huizinga, Jan Heesterman, and David Shulman on Indian kingship and theater, I then attempt to decode the local and the global, as well as the seen and unseen, meaning of this textile.
Stepping into the Breach of Federal Inaction: Reforming the Financing of Long-Term Services and Supports in the Post-CLASS Era
Authors: Miller Edward Alan , Nadash Pamela , Cohen Marc A. 
Published: June 2020

Abstract
The growing need for long-term services and supports (LTSS) poses significant challenges to both individuals and government. This article documents the continuing failure to tackle this problem at the national level—a failure that was most recently seen in the fallout from the Affordable Care Act (ACA), which included the single piece of national legislation ever enacted to comprehensively address LTSS costs: the Community Living Assistance Services and Supports (CLASS) Act. The CLASS Act was passed as part of the ACA (Title 8) but was repealed in 2013. Following its demise, policy experts and some Democrats have made additional proposals for addressing the LTSS financing crisis. Moreover, significant government action is taking place at the state level, both to relieve financial and emotional burdens on LTSS recipients and their families and to ease pressure on state Medicaid budgets. Lessons from these initiatives could serve as opportunities for learning how to overcome roadblocks to successful policy development, adoption, and implementation across states and for traversing the policy and political tradeoffs should a policy window once again open for addressing the problem of LTSS financing nationally.
Isolation and characterization of a novel bacterial strain from a Tris-Acetate-Phosphate agar medium plate of the green micro-alga Chlamydomonas reinhardtii that can utilize common environmental pollutants as a carbon source
Authors: Mitra Mautusi , Nguyen Kevin Manoap-Anh-Khoa , Box Taylor Wayland , Gilpin Jesse Scott , Hamby Seth Ryan , Berry Taylor Lynne , Duckett Erin Harper 
Published: June 2020

Background: Chlamydomonas reinhardtii, a green micro-alga can be grown at the lab heterotrophically or photo-heterotrophically in Tris-Phosphate-Acetate (TAP) medium which contains acetate as the sole carbon source. When grown in TAP medium, Chlamydomonas can utilize the exogenous acetate in the medium for gluconeogenesis using the glyoxylate cycle, which is also present in many bacteria and higher plants. A novel bacterial strain, LMJ, was isolated from a contaminated TAP medium plate of Chlamydomonas. We present our work on the isolation and physiological and biochemical characterizations of LMJ. Methods: Several microbiological tests were conducted to characterize LMJ, including its sensitivity to four antibiotics. We amplified and sequenced partially the 16S rRNA gene of LMJ. We tested if LMJ can utilize cyclic alkanes, aromatic hydrocarbons, poly-hydroxyalkanoates, and fresh and combusted car motor oil as the sole carbon source on Tris-Phosphate (TP) agar medium plates for growth. Results: LMJ is a gram-negative rod, oxidase-positive, mesophilic, non-enteric, pigmented, salt-sensitive bacterium. LMJ can ferment glucose, is starch hydrolysis-negative, and is very sensitive to penicillin and chloramphenicol. Preliminary spectrophotometric analyses indicate LMJ produces pyomelanin. NCBI-BLAST analyses of the partial 16S rRNA gene sequence of LMJ showed that it matched to that of an uncultured bacterium clone LIB091_C05_1243. The nearest genus relative of LMJ is an Acidovorax sp. strain. LMJ was able to use alkane hydrocarbons, fresh and combusted car motor oil, poly-hydroxybutyrate, phenanthrene, naphthalene, benzoic acid and phenyl acetate as the sole carbon source for growth on TP-agar medium plates. Conclusions: LMJ has 99.14% sequence identity with the Acidovorax sp. strain A16OP12 whose genome has not been sequenced yet. LMJ’s ability to use chemicals that are common environmental pollutants makes it a promising candidate for further investigation for its use in bioremediation and, provides us with an incentive to sequence its genome.
<p><strong>Description of <em>Kelypitnus steineri</em>, a minute-sized spider beetle (Coleoptera: Ptinidae) from Madagascar</strong></p>
Authors: PHILIPS THOMAS KEITH , MYNHARDT GLENÉ 
Published: June 2020

A new endemic Madagascan genus and species of spider beetle from Toliara Province in southwest Madagascar is described. The genus Kelypitnus gen. nov. is characterized by its small size and dark brownish-black color, a short lateral margin on the pronotum, a concave proventrite, 10-segmented antennae, and the presence of a small, conspicuous raised ring with a central cavity on the first abdominal ventrite in the male. The single species, Kelypitnus steineri sp. nov. is diagnosed, described, and illustrated and compared to the two most similar genera known, Neoptinus Gahan and Pitnus Gorham. Key words: Kelypitnus, Coleoptera, Ptinidae, new genus, Madagascar, Bostrichoidea, endemic
A JUDICIALIZAÇÃO DO ACESSO À CRECHE: DESAFIOS PARA UM ATENDIMENTO COM QUALIDADE
Authors: Vieira Juliana Andrade , Rosa Sanny Silva da 
Published: June 2020

O artigo apresenta um panorama da judicialização da educação infantil no Brasil, focalizando os casos de vagas em creches municipais, com base em levantamento de estudos e pesquisas realizadas entre 2008 e 2019. Aborda e discute as tensões entre a garantia do direito à educação, prevista na legislação educacional brasileira, e o direito das famílias, dos bebês e das crianças pequenas a um atendimento com qualidade. Apresenta dados parciais de uma pesquisa em andamento sobre a judicialização do acesso em creches públicas do município de Santo André. Dada a complexidade do problema, conclui que embora as reivindicações individuais tenham legitimidade, o problema precisa ser enfrentado com políticas públicas que reconheçam e garantam direitos coletivos arduamente conquistados no Brasil.