bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Quantum Mechanism of Earthquakes as Exemplified by a Sudden Ejection of Rocks and Gas from a Rock Mass during the Process of a Coulomb Explosion
Authors: Bychkov Serguei 
Published: October 2020

Abstract
At the moment, there are several hypotheses in geophysics that explain especially dangerous processes of the earth's crust movements - sudden outbursts of rocks and gas from a rock mass from the point of view of classical physics. Despite the fact that various macroscopic systems can be accurately described using classical mechanics and electrodynamics, a real mechanism and a working model of this phenomenon cannot be built. Consequently, to develop a model of sudden outbursts of rocks and gas, it is necessary to apply new approaches and methods, different from the description of macroscopic systems. This article describes a quantum version of the process of the ejection of rocks from a rock mass. In particular, we described the mechanism of the Coulomb explosion that occurs in the rocks of the earth's crust with a sharp change in rock pressure and built a model of the sudden release of rocks and gases. In our opinion, the quantum processes described by us can be sources not only of sudden outbursts and rockslide but also sources of more formidable phenomena - earthquakes and volcanic explosions.
Overlooked nitrous oxide emissions driven by bedrock weathering
Authors: Wan Jiamin , Tokunaga Tetsu , Williams Kenneth , Brown Wendy , Newman Alexander , Dong Wenming , Bill Markus , Henderson Amanda , Beutler Curtis , Harvey-Costello Nydra , Conrad Mark , Bouskill Nicholas , Hubbard Susan 
Published: October 2020

Abstract
Atmospheric nitrous oxide (N2O) contributes directly to global warming, yet current models1-5 overlook bedrock-contained nitrogen (rock-N), the largest terrestrial N pool6, as a N2O source. Although rock-N release rates are large6-9, incomplete understanding on the fate of released rock-N has obscured connections between rock-N and atmospheric N2O. This connection emerged through our field studies of a hillslope underlain by marine shale. Bedrock weathering within the zone of the seasonally fluctuating water table controls the weathering depth, hence the release of rock-N. At this site, rock-N weathering contributes 78% of the subsurface reactive-N, with ~22% derived from atmospheric deposition and biological nitrogen fixation, commonly regarded as the sole sources of reactive-N in pristine environments10,11. About 56% of reactive-N denitrifies, including 14% emitted as N2O into the atmosphere. The remaining reactive-N discharges in porewaters to a floodplain where additional denitrification likely occurs. Using global rock-N releases of 11–18 Tg y-1 8, our measurements extrapolate to a weathering driven efflux of 1.3–2.1 Tg N-N2O y-1, consistent with a flux of 1.0–1.7 Tg N- N2O y-1 solely derived from the literature. Thus, bedrock weathering contributes approximately 10-17 % of nitrous oxide to the current global estimate of ~10 Tg y-1.
Prevalence and socioeconomic inequality in screen time, phone, and tablet use in children in Iran
Authors: Moradi Ghobad , Piroozi Bakhtiar , Ghaderi Ebrahim , Mostafavi Farideh , Zakaryaei Farima , Mehrad Jahan , Alavi Zahra 
Published: October 2020

Abstract
Background: Nowadays, children spend a lot of time during the day in front of the television(TV) and using their phones. We aimed to evaluate screen time and phone use in Iranian children and their relation to the socioeconomic status of children's families.Methods: This descriptive analytical study was done on 10-12-year-old children from Kurdistan, Fars, and Markazi provinces. Cluster sampling was used for sampling. Date collection included completing demographic questionnaires, calculating BMI of children and phone & tablet use, screen time, and socioeconomic status. We used linear and logistics regression to estimate the final model and decomposition method of the Oaxaca. The concentration index and the concentration curve were used to measure and illustrate socioeconomic inequalities. All analysis was conducted with the Stata / SE 14.0 software.Results: 1590 children (52.58% boys) were enrolled in our study, 594 (74%) of boys and 420 (56%) of girls had daily Screen Time activities for more than two hours, and 388 (48.20%) of boys and 211 (28.20%) of girls use mobile phones and tablets for more than two hours a day. Screen Time activities were significantly higher in boys, older children, higher BMIs, more educated mothers, and 35<year-old fathers (P_VALUE <0.05). The use of mobile phones and tablets by boys, ten-year-olds, families of four or less, older BMIs, children with higher levels of parental education, and more educated mothers is significantly higher (P_VALUE <0.05). In addition, the Concentration Index for Screen Time activities (C = 0.083) and phone or tablet use (C = 0.536), shows that the Screen Time, phone or tablet use activities are higher in children with high socioeconomic status.Conclusion: The screen time activities and phone & tablet use are higher in children with high socioeconomic status. Also, many other factors like gender, age, BMI, parent's education, and age can affect screen time activities and phone & tablet use in children. It is recommended to measure the effectiveness of the changeable factors by modifying and controlling these factors in future studies.
The Functional Examination of Conserved and Non-conserved lncRNA in Allotetraploid Gossypium hirsutum
Authors: Guan Xueying , Wang Luyao , Han Jin , Lu Kening , Li Menglin , Gao Mengtao , Cao Zeyi , Zhao Ting , Chen Xue , Tao Xiaoyuan 
Published: October 2020

Abstract
Background The relationship between the lncRNA conservation level and its function is controversial. One of the technique barrier to address this question is how to define the conserved non-coding genes across species.Results We developed an evolutionary model using diploid and allotetraploid cotton species to identify 80% of the non-coding transcripts unique to the allotetraploid cotton in comparison with its diploid ancestors. This led us to define conserved lncRNA and non-conserved lncRNA based on their conservation throughout polyploid evolution. LncRNA expression was preferentially associated with the flanking protein-coding genes, indicating a regulatory role in cis in response to environmental stimuli. However, the conserved and non-conserved lncRNAs showed no difference in their levels of association with the expression of the flanking protein-coding genes. The 111 selected highly expressed conserved and non-conserved lncRNA candidates were subjected to a virus-induced gene silencing operation that was integrated with abiotic stress treatments. From the low-throughput, functional screening pilot test, we obtained candidate lncRNAs related to plant height, tolerance to drought and other abiotic stresses. Conclusions The conservation level of the lncRNAs may impact on their expression patterns and functions as individual case rather than in genome wide.
CRISPR/Cas9&nbsp;Mediated Gene Modification Ameliorates Abnormal Phenotypes in SCA3/MJD&nbsp;Disease Patient Derived Induced Pluripotent Stem Cells
Authors: He Lang , Wang Shang , Zhao Huifang , Li Shuai , Han Xiaobo , Chen Zhao , Wang Chunrong , Peng Yun , Peng Huirong , Peng Linliu , Xie Yue , Lei Lijing , Deng Qi , Wan Linlin , Wan Na , Yuan Hongyu , Gong Yiqing , Zou Guangdong , Li Zhiyuan , Tang Beisha , Jiang Hong 
Published: October 2020

Abstract
Background：Spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) is a progressive autosomal dominant neurodegenerative disease caused by abnormal CAG repeats in exon 10 of ATXN3. The accumulation of the mutant ataxin3 proteins carrying polyglutamine (polyQ) lead to selective degeneration of neurons. Therapeutic strategies were used to inhibit mutant ATXN3 expression, including antisense oligonucleotides, RNA interference and more recently CRISPR/Cas9 genome-editing based approaches. Since the pathogenesis of SCA3 has not been fully elucidated, and no effective therapies can be used, it is crucial to investigate the pathogenesis and seek new therapeutic strategies of SCA3/MJD. Methods: Here we used the paired sgRNA/Cas9 nickases and Cre-loxP mediated homologous recombination (HR) strategy to precisely modify the abnormal CAG expansions in the ATXN3 of SCA3/MJD patient derived induced pluripotent stem cells (SCA3/MJD-iPSCs). Meanwhile, we investigated the disease related phenotypes in differentiated neurons, including electrophysiological characteristics, IC2-positive aggregations, mitochondrial membrane potentials (MMPs), glutathione (GSH) expressions, intracellular reactive oxygen species (ROS), Ca2+ concentrations and malondialdehyde (MDA) levels. Results: SCA3/MJD-iPSCs can be corrected by the replacement of the abnormal CAG expansions with normal repeats using HR. Besides, corrected SCA3/MJD-iPSCs retained pluripotent and normal karyotype, which could be differentiated into neuron cells (NCs) and maintained electrophysiological characteristics. The expression of differentiation markers and electrophysiological characteristics were similar among the control individuals, SCA3/MJD patients and isogenic control SCA3/MJD groups. Furthermore, this study proved that the phenotypic abnormalities in SCA3/MJD-iPSCs derived NCs, including aggregated polyQ toxic protein, decreased MMPs and GSH expressions, increased ROS, Ca2+ concentrations and MDA levels, all were rescued in the corrected SCA3/MJD-NCs. Conclusion: The present study firstly suggested that the genetically corrected SCA3/MJD-iPSCs and associated phenotypic abnormalities, which will provide an ideal models for molecular mechanism research and autologous stem cell therapy.
Acute kidney injuries induced by thrombotic microangiopathy following severe hemorrhage in puerperants: A case series and literature review
Authors: Wang Xu , Liu Chun-yan , Yang Yue , Zou Gu-ming , Zhuo Li , Han Su-hui , Li Wen-ge 
Published: October 2020

Abstract
Background: Acute kidney injury (AKI) in puerperants is generally caused by acute tubular necrosis and occasionally by thrombotic microangiopathy (TMA) following post-partum hemorrhage. However, TMA leads to worse clinical outcomes and is rarely reported in the literature. Therefore, this study aimed to evaluate the pathological mechanism behind the development of TMA in puerperants to improve the diagnosis and treatment of this condition.Methods: Three patients diagnosed with severe postpartum hemorrhage and TMA from 2014 to 2017 at a nephrology center were retrospectively investigated. Results: All patients had severe hemorrhage during delivery with a mean blood loss, 4.0 L (range, 2.7-5.0 L). AKI developed rapidly in these patients and was treated with hemodialysis. Following treatment, the mean volume of packed red blood cells was 2.3 L (range, 1.2-3.6 L), and the mean volume of resuscitation fluid was 3.7 L (range, 3.5-4.0 L). All patients had renal biopsy specimens with typical TMA and ATN changes on light microscopy. Two patients required a hysterectomy while another two patients received respiratory support. Only one patient received plasma exchange. None of the patients had recovered normal kidney function by the final follow-up (26-61 months), with two patients having stage 3 chronic kidney disease (CKD), and one patient having an end-stage renal disease (ESRD) requiring maintenance hemodialysis. Conclusion: Severe postpartum hemorrhage could lead to TMA, in addition to the common finding of ATN. Renal histology revealed that poor renal outcomes could be attributed to TMA coexisting with ATN. The potential mechanism was ischemia-reperfusion, which was followed by endothelial cell injury and activation of the alternative complement pathway.
Carbonaceous aerosols in Indian Himalayan atmosphere: seasonal abundance, altitudinal variation and source analysis
Authors: KUMAR AMIT , Singh Sachchidanand , Kumar Niraj , Singh Narendra , Kumar Krishan , Mishra Amit K. , Chourasiya Sapna , Kushwaha H.S. 
Published: October 2020

Abstract
The present study reports carbonaceous aerosol concentrations determined in total suspended particles (TSP) from three mountainous sites viz. Devasthal Peak, Manora Peak and Bhimtal and one low-land Tarai urban site at Pantnagar in Kumaon region of Uttarakhand, western Himalaya. The concentrations of organic carbon (OC) and elemental carbon (EC) were estimated following IMPROVE_thermal optical reflectance protocol. Results showed that TSP and OC/EC concentrations varied significantly and decreased with increasing altitudes in two seasons. Seasonal/(diurnal) analysis indicated TSP and OC/EC concentrations at mountainous sites exhibited higher values in summer/(day-time), respectively while tarai site had higher values in winter/(night-time). Higher summer/(day-time) values at mountainous sites could be associated with local emissions along with vertical movement of atmospheric boundary layer resulting uplift of air pollutants due to convective motions generated in valley region. OC and EC were noted to be strongly correlated (correlation coefficient > 0.8) indicated similar emissions source and atmospheric processes. The ratios of OC/EC were observed in the range of 2.4 to 9.3, 2.1 to 8.6, 1.9 to 4.3 and 1.8 to 3.2 for Devasthal, Manora peak, Bhimtal and Pantnagar, respectively, suggested mixed sources of biomass burning, coal combustion and vehicular emissions. The large variations in OC/EC ratios at studied sites suggested presence of secondary organic carbon (SOC). Mountainous sites experienced higher % SOC contributions (41 – 45%) to total OC in winter than low-land tarai urban site could be due favourable conditions for condensation of photo-oxidation products of organic species and biogenic VOCs emissions.
Exploring Leave Events for Aboriginal and Torres Strait Islander People From Australian Tertiary Services: A Systematic Literature Review
Authors: Coombes Julieann , Sazali Syazlin , Mackean Tamara , Banks Margaret , Egana Nilva , Ryder Courtney , Hunter Kate , Porykali Bobby , Bourke Elizabeth , Bennett-Brook Keziah 
Published: October 2020

Abstract
Objective The primary objective of this systematic review was to identify contributing causes to leave events from health services for Australian patients. The second objective was to identify evidence based preventative measures for effectively reducing leave events, which could be implemented. Study design Articles published in Australia were included if they reported on Aboriginal and/or Torres Strait Islander people and other Australians who leave health services prior to being seen or discharged by a medical professional. Two researchers screened each abstract and independently reviewed full text articles. Study quality was assessed, and data were extracted with standardised tools.Data sources MEDLINE and Google Scholar were searched for relevant publications from May 27th to June 30th, 2020. The search returned 30 relevant records. Nine additional records were identified by manual search in Google Scholar. References of included articles were searched. From these articles, 11 met the inclusion criteria. Of these 5 were from New South Wales, 2 from Western Australia, 1 each from Queensland and Northern Territory, two were conducted nationally. Data synthesis Four studies used a retrospective cohort method, one included patient interviews,(1) Four cohort studies and two systematic reviews were included. Two government reports and one health policy document were included in this review. All studies were from Australia using mixed methods.Conclusions This review identified causes for, and evidence based preventative measures that have been or could be implemented to reduce Leave Events and describes additional terms and definitions used for Leave Events.
Rethinking Mental Health Wellness Among Adolescents: An Integrative Review Protocol of Mental Health Components
Authors: Orth Zaida , Wyk Brian van 
Published: October 2020

Abstract
Background: Adolescence have been overlooked in global public health initiatives as this period is generally considered to be the healthiest in an individual’s life course. However, the growth of the global adolescent population along and their changing health profiles have called attention to the diverse health needs of adolescents. However, the increased attention toward adolescent health has accentuated existing gaps as global health reports have emphasised that there is a continued need for valid and reliable health data. In this context, evidence has shown that mental health issues constitute one of the greatest burdens of disease for adolescents. The paucity of research on adolescent mental health and wellbeing may be related to the lack of validated instruments. This integrative review aims to unpack the meaning of mental health wellness among adolescents and its associated constructs by analysing and synthesising peer-reviewed empirical and theoretical research on adolescent mental health. In doing this, we will develop a working definition of adolescent mental health wellness that can be used to develop an instrument aimed at measuring adolescent mental health wellness.Methods: The integrative review is guided by the five steps described by Whittemore and Knafl. A comprehensive search strategy which will include carefully selected terms that correspond to the domains of interest (mental health wellness) will be used to search for relevant literature on electronic databases, grey literature and government or non-governmental organisations (NGO) websites. Studies will be included if they describe and/or define general mental health wellbeing in adolescent populations aged 10-19. The screening and reporting of the review will be conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Data from the integrative review will be analysed using narrative framework synthesis for qualitative and quantitative studies Conclusion: This integrative review aims to search for and synthesise current research regarding adolescent mental health wellbeing to identify how wellbeing is being described and conceptualised. We aim to identify gaps and to contribute to a more comprehensive definition of mental health wellness which can aid in the development of an age- and culturally appropriate measure of adolescent mental health wellness
Methodology for Optimization of the Electric Wire Arc - Spraying Process to the Mixture of Coatings 140MXC-530AS and 140MXC- 560AS Using a Multi-objective Genetic Algorithm
Authors: Rojas Héctor F. , Guzmán María A. , Luna Oscar E. , Aragón Diana F. 
Published: October 2020

Abstract
The Corporation of Science and Technology for the Development of the Maritime and Fluvial Shipbuilding Industry COTECMAR has been using for more than 4 years the process of electric arc thermal projection with commercial materials such as 530AS, 560AS and 140MXC to mitigate corrosion phenomena and wear of the different devices that make up the boats. The problem lies in mixing these materials (140MXC-530AS and 140MXC-560AS) to produce dissimilar coatings, making it more difficult to optimize the process, whose problem lies in the parameterization of the arc-beam thermal imaging equipment. In the first phase of the project, a Taguchi L9 (34-2) model (fractional factorial orthogonal arrangement) was used to produce the coatings, taking into account the projection parameters of the equipment such as current (A), voltage (V) Primary air pressure (Pp) and secondary air pressure (Ps), which were considered as input variables or experiments for the optimization process. Subsequently the coatings were characterized by techniques such as Scanning Electron Microscopy (SEM) and microhardness to take these data as attributes or output of results in order to obtain the minimization of the size of the projected particles (corrosion) and the microhardness maximization of the coatings (wear). Symbolic regression was used as a technique for obtaining the mathematical models (objective functions), which was done through the "Eureqa Formulize-Desktop" program, because it is considered very complex the modeling of all input variables by conventional mathematical methods. The adaptation of the NSGA-II Multi-Objective Genetic Algorithm was performed through a structured programming in "Matlab", being able to verify that the optimal Pareto fronts obtained in the runs with this Algorithm meet the requirements of the objective functions which are related with the attributes of the selected coatings.
Numerical Study on Flow Characteristics of Airfoil With Bionic Micro-Grooves
Authors: Wu Zhenren , Yang Yufei , Liu Mei , Zhang Kaishun 
Published: October 2020

Abstract
For the purpose of exploring the influence of the location of the bionic micro grooves on the flow characteristics of the airfoil, three airfoil models with bionic grooves were established according to the different positions of the bionic grooves. Large eddy simulation is used to numerically simulate the flow of different airfoils. Compared with the smooth airfoil, the flow characteristics and aerodynamic performance parameters of the bionic micro-groove airfoil are analyzed at 6° angle of attack, 24 m/s and 30 m/s speed. The results show that the three types of bionic grooved airfoil suppress the thickness and flow length of the separation zone, making the reattachment position of the separation zone more forward than that of the smooth airfoil, thus having different degrees of separation of the airfoil surface boundary layer. Control effect. In addition, the existence of bionic micro-grooves reduces the vortex structure in the near-wall zone, reduces the center height of the separation zone, and reduces the normal velocity gradient, which weakens the energy dissipation in the flow. Airfoil-H1 airfoil has the best flow characteristics and aerodynamic performance at 24 m/s, the drag reduction rate is the largest, reaching 16.99%, and the lift-to-drag ratio increases by 16.34%. The Airfoil-H2 airfoil has the best effect at 30 m/s, the drag reduction rate is the largest, reaching 18.09%, and the lift-to-drag ratio increases by 18.86%. Airfoil-H3 airfoil has a lower effect, but the effect becomes more pronounced as the speed increases. As the mainstream speed increases from 24 m/s to 30 m/s, the optimal airfoil will gradually transition from Airfoil-H1 airfoil to Airfoil-H2 airfoil regardless of flow characteristics or aerodynamic performance parameters. It is found that there is the best matching value between the location of the bionic groove and the mainstream speed, so that the groove can play the best improvement effect.
Pyoderma Gangrenosum Mimicking Antiphospholipid Antibody Syndrome in a Child With Juvenile Systemic Lupus Erythematosus
Authors: gürgöze metin kaya , Kara Aslıhan , sarı Mehmet yusuf , Çalık İlknur , Akarsu Saadet 
Published: October 2020

Abstract
Background: Although pyoderma gangrenosum (PG) -like lesions have been rarely described in adults with the antiphospholipid antibody syndrome (APS) and systemic lupus erythematosus (SLE), the occurrence of PG as a preceding manifestation of APS in children with SLE has not been reported until. We present a young girl with SLE and APS who developed progressive extstensive ulcerations that were consistent with PG.Case presentation: A 14-year-old girl with a 2-year history of SLE was admitted to our department, complaining painful crusted ulcerations on her legs. Skin biopsy was reported as PG. However, she did not respond to immunosuppressive therapy administered. When her skin biopsy findings is reassessed in keeping with the positive anticardiolipin antibody results, superficial small vessel microthrombosis was observed. Diagnosis of APS and PG developing secondary to SLE were made. It was resulted in marked clinical improvement with anticoagulation therapy in addition to immunosuppressives as is recommended in APS. Conclusions: Based in clinical, pathological and response to proposed treatment, we can state that PG -like lesions in children with SLE could be considered as a secondary form of APS.