bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation between GRIK2 rs6922753, rs2227283 polymorphism and aggressive behaviors with Bipolar Mania in the Chinese Han population
Authors: Ma Haibo , Xun Guanglei , Zhang Renyun , Yang Xiaohua , Cao Yu 
Published: October 2019

AbstractObjectivesAnimal studies have shown that glutamate receptor ionotropic kainate 2 (GRIK2) gene knockout mice are more impulsive and aggressive. This study aims to verify whether the rs6922753 and rs2227283 polymorphisms of the GRIK2 gene are associated with both aggressive behavior and bipolar mania in the Chinese Han population.MethodsPolymerase chain reaction (PCR) was applied in the genotype rs6922753 and rs2227283 polymorphisms of the GRIK2 gene in 201 bipolar manic patients with aggressive behaviors, 198 bipolar manic patients without aggressive behaviors, and 132 healthy controls. The Modified Overt Aggression Scale (MOAS) was used to evaluate aggressive behavior in patients with bipolar mania.ResultsNo correlation was found between aggressive behavior and the rs6922753 polymorphism in the three groups. The A/A genotype and A allele of the rs2227283 polymorphism were found significantly more frequently in patients with aggressive behavior than in healthy controls (p = .004 and p = .013, respectively) and in patients with nonaggressive behavior (p = .002 and p = .018, respectively). The A/A genotype and A allele were associated with an increased risk of aggressive behavior.ConclusionThis study suggests that the rs2227283 polymorphism of the GRIK2 gene is related to aggressive behaviors in bipolar manic patients and that the A/A genotype and A allele may increase the risk of the aggressive behavior in bipolar manic patients.
Fungicidal Activity of Essential Oils from Cinnamomum cassia against the Pathogenic Fungi of Panax notoginseng Diseases
Authors: Ma Yu‐Nan , Chen Chuan‐Jiao , Li Qingqing , Wang Wei , Xu Fu‐Rong , Cheng Yong‐Xian , Dong Xian 
Published: October 2019

AbstractThe frequent disease of Panax notoginseng caused by the pathogenic fungi in field cultivation has become the major threaten to the sustainable development of it. The present study was conducted to find natural agent with potential inhibition against pathogen. Therefore, the inhibitory effects of Cinnamomum cassia (L.) J.Presl essential oils (EOs) against P. notoginseng associated pathogenic fungi were conducted both in vitro and in vivo experiments. The results of the Oxford cup test revealed that C. cassia dry bark EO (50 mg/mL) had significant inhibitory activity on the growth of all tested fungi, and the growth of various pathogens was completely inhibited, except for that of Fusarium solani. Therefore, the constituents of C. cassia EOs were analyzed by GC/MS, and the research demonstrated that the main constituents of C. cassia dry bark EO were trans‐cinnamaldehyde (75.65 %), (E)‐2‐methoxycinnamaldehyde (6.08 %), cinnamaldehyde (3.47 %) and cinnamyl acetate (1.02 %). The MIC results showed that C. cassia dry bark EO and the main compounds had good antifungal effect on the tested strains, and the inhibitory effect was similar to that of hymexazol (chemical pesticide). By analyzing the value of the fraction inhibitory concentration index (FICI), additive effects, irrelevant effects and synergistic effects were observed after the mixture of hymexazol against various pathogens. Moreover, in vivo model showed that C. cassia dry bark EO could reduce the occurrence of anthrax in P. notoginseng. To widen the resources of C. cassia available, the compositions of both C. cassia fresh bark and leaf EOs were also tested and many common compositions existed among them. Taken together, it was concluded that C. cassia EO had the potential use in the field to reduce the pathogenic disease.
In‐hospital outcome of peripheral vascular intervention in dialysis‐dependent end‐stage renal disease patients
Authors: Moussa Pacha Homam , Al‐khadra Yasser , Darmoch Fahed , Soud Mohamad , Mamas Mamas A. , Moussa Pacha Abdulghani , Zaitoun Anwar , Kaki Amir , AlJaroudi Wael A. , Alraies M. Chadi 
Published: October 2019

AbstractBackgroundThe impact of end‐stage renal disease (ESRD) on peripheral vascular intervention (PVI) outcome remains incompletely elucidated.ObjectivesWe sought to compare the outcome of PVI in dialysis patients with those with normal kidney function.MethodsUsing weighted data from the National Inpatient Sample database between 2002 and 2014, we identified all peripheral artery disease (PAD) patients aged ≥18 years that underwent PVI. Multivariate logistic regression analysis was performed to examine in‐hospital outcomes.ResultsOf 1,186,192 patients who underwent PVI, 1,066,830 had normal kidney function (89.9%) and 119,362 had ESRD requiring dialysis (10.1%). Critical limb ischemia was more prevalent in dialysis patients (63.2 vs. 34.0%, p < .001). Compared with normal kidney function group, ESRD requiring dialysis was associated with higher in‐hospital mortality (1.5 vs. 4.2%, adjusted OR: 2.13 [95% CI: 2.04–2.23]) and longer length of hospital stay (median 3 days, Interquartile range [IQR] (0–6) vs. 7 days, IQR (4–18); p < .001). Dialysis patients had higher incidence of major adverse cardiovascular events (composite of death, myocardial infarction, or stroke; 14.3 vs. 9.8%, p < .001) and net adverse cardiovascular events (composite of MACE, major bleeding, or vascular complications; 40.8 vs. 29.1%, p < .001). ESRD patients less frequently underwent open bypass (5.6 vs. 8.5%, p < .001) and more frequently had major amputation (10.3 vs. 3.0%, p < .001) compared with normal kidney function group.ConclusionPAD patients on dialysis who underwent PVI have higher rates of mortality and adverse outcomes as compared to those with normal kidney function.
Improved Photoactivities of Large‐surface‐area g‐C3N4 for CO2 Conversion by Controllably Introducing Co‐ and Ni‐Species to Effectively Modulate Photogenerated Charges
Authors: Zhang Xuliang , Zhang Xinxin , Ali Wajid , Chen Xiaowei , Hu Kang , Li Zhijun , Qu Yang , Bai Linlu , Gao Yiwen , Jing Liqiang 
Published: October 2019

AbstractSimultaneously modulating photogenerated electrons and holes by introducing transitional metals species on carbon nitride (g‐C3N4) are highly desired for effectively photocatalytic converting CO2. Herein, a cyanuric acid‐melamine preassembled approach is developed to obtain large‐surface‐area g‐C3N4 with high photoactivity for CO2 conversion, and its photoactivity is improved by controllably modifying Co‐species during the synthetic process of g‐C3N4, attributed to its hole capture capability and catalytic capability for water oxidation. Moreover, the photoactivity is further improved by decorating Ni‐species on g‐C3N4, attributed to its electron capture capability and catalytic capability for CO2 reduction. Noticeably, simultaneously modulating holes and electrons displays a noticeable synergy on improving photocatalytic activities. Interestingly, the photoactivity of amount‐optimized Co and Ni co‐modified g‐C3N4 is 3.1‐time higher than that of pristine g‐C3N4, with the quantum efficiency improvement of 4.5 time at 405 nm. This work will provide a feasible way of simultaneously modulating electrons and holes to fabricate high‐performance g‐C3N4‐based nano‐sized photocatalysts for CO2 conversion.
Electrochemical Synthesis of Ammonia Based on a Perovskite LaCrO3 Catalyst
Authors: Ohrelius Mathilda , Guo Haoran , Xian Haohong , Yu Guangsen , Alshehri Abdulmohsen Ali , Alzahrani Khalid Ahmad , Li Tingshuai , Andersson Martin 
Published: October 2019

AbstractElectrochemical synthesis of ammonia through the nitrogen reduction reaction (NRR) has the possibility to revolutionize our production of ammonia and to save our planet from both emissions and large energy consumption. In this study, a perovskite structured lanthanum chromite catalyst (LaCrO3) is synthesized, characterized as well as electrochemically evaluated for NRR. The highest ammonia yield is obtained at −0.8 V vs. reversible hydrogen electrode with an ammonia formation rate of 24.8 μg h−1 mg−1cat, and a Faradaic efficiency of 15 %. Material calculation further confirms the possible mechanism of ammonia formation with the aid of LaCrO3 catalyst. The resulting conclusion offers a great alternative with the easily produced and low‐cost perovskite structured electrocatalysts for ammonia production.
Polyoxometalates‐Based Metal–Organic Frameworks Made by Electrodeposition and Carbonization Methods as Cathodes and Anodes for Asymmetric Supercapacitors
Authors: Liu Yao‐Zhi , Yao Wei , Gan Hong‐Mei , Sun Chun‐Yi , Su Zhong‐Min , Wang Xin‐Long 
Published: October 2019

AbstractHybrid materials have obtained well‐deserved attention for energy storage devices, because they show high capacitances and high energy densities induced by the synergistic effect between complementary components. Polyoxometalate‐based metal–organic frameworks (POMOFs) possess the abundant redox‐active sites and ordered structures of polyoxometalates (POMs) and metal–organic frameworks (MOFs), respectively. Here, an asymmetric supercapacitor (ASC) NENU‐5/PPy/60//FeMo/C was fabricated in which both its electrodes are prepared from POMOF precursors. A typical POMOF material, NENU‐5, was first connected with polypyrrole (PPy) through electrodeposition to form the cathode material NENU‐5/PPy. Another representative POMOFs material, PMo12@MIL‐100, was carbonized to obtain the anode material FeMo/C. Cathode NENU‐5/PPy exhibited an extraordinary capacitance of 508.62 F g−1 (areal capacitance: 2034.51 mF cm−2). In addition, anode FeMo/C shows excellent cyclic stability attributed to its unique structure. Finally, benefiting from the outstanding capacitances and structural merits of the anode and cathode, assembled asymmetric supercapacitor NENU‐5/PPy/60//FeMo/C achieves an energy density of 1.12 mWh cm−3 at a power density output of 27.78 mW cm−3, as well as a notable life of 10 000 cycles with an capacity retention of 80.62 %. Thus, the unique ASC is strongly competitive in high capacitance, long cycle life, and high energy‐required energy storage devices.
A Facile Route for Constructing Effective Cu−Nx Active Sites for Oxygen Reduction Reaction
Authors: Li Jingjing , Xia Wei , Wang Tao , Zheng Lirong , Lai Yue , Pan Junjie , Jiang Cheng , Song Li , Wang Mengyu , Zhang Huting , Chen Na , Chen Guang , He Jianping 
Published: October 2019

AbstractThe coordination number between copper and nitrogen in copper/nitrogen‐based electrocatalysts is important for boosting the oxygen reduction reaction (ORR). However, it is difficult to control unsaturated copper/nitrogen constructions as well as to compare their ORR performances in similar carbon matrices in a simple yet efficient manner. In this study, we have easily attained two types of Cu+−N2 and Cu2+−N4 constructions simply by etching pyrolyzed Cu‐doped zeolitic imidazolate framework nanoleaves (Cu‐ZIF‐L) with sulfuric acid or nitric acid, respectively. X‐ray absorption near‐edge structure (XANES) and extended X‐ray absorption fine structure (EXAFS) spectra were recorded to further confirm the different copper/nitrogen constructions after the different acid treatments. Electrochemical studies have demonstrated that Cu+−N2 sites are more active in boosting the ORR performance than Cu2+−N4 sites. Furthermore, Cu−N/C−H2SO4, used as an air cathode in a zinc‐air battery, exhibited excellent performance and stability.
In Situ Metal‐Assisted Ligand Modification Induces Mn4 Cluster‐to‐Cluster Transformation: A Crystallography, Mass Spectrometry, and DFT Study
Authors: Zhang Yu‐Yi , Zhang De‐Shan , Li Tian , Kurmoo Mohamedally , Zeng Ming‐Hua 
Published: October 2019

AbstractDehydration of (S,S)‐1,2‐bis(1H‐benzo[d]imidazol‐2‐yl)ethane‐1,2‐diol (H4L) to (Z)‐1,2‐bis(1H‐benzo[d]imidazol‐2‐yl)ethenol) (H3L′) was found to be metal‐assisted, occurs under solvothermal conditions (H2O/CH3OH), and leads to [MnII4(H3L)4Cl2]Cl2⋅5 H2O⋅5 CH3OH (Mn4L4) and [MnII4(H2L′)6(μ3‐OH)]Cl⋅4 CH3OH⋅H2O (Mn4L′6), respectively. Their structures were determined by single‐crystal XRD. Extensive ESI‐MS studies on solutions and solids of the reaction led to the proposal consisting of an initial stepwise assembly of Mn4L4 from the reactants via [MnL] and [Mn2L2] below 80 °C, and then disassembly to [MnL] and [MnL2] followed by ligand modification before reassembly to Mn4L′6 via [MnL′], [MnL′2], and [Mn2L′3] with increasing solvothermal temperature up to 140 °C. Identification of intermediates [Mn4LxL′6−x] (x=5, 4, 3, 2, 1) in the process further suggested an assembly/disassembly/in situ reaction/reassembly transformation mechanism. These results not only reveal that multiple phase transformations are possible even though they were not realized in the crystalline state, but also help to better understand the complex transformation process between coordination clusters during “black‐box” reactions.
Recent Progress in Organic–Inorganic Composite Solid Electrolytes for All‐Solid‐State Lithium Batteries
Authors: Zhang Dechao , Xu Xijun , Qin Yanlin , Ji Shaomin , Huo Yanping , Wang Zhuosen , Liu Zhengbo , Shen Jiadong , Liu Jun 
Published: October 2019

AbstractConventional lithium‐ion batteries, with flammable organic liquid electrolytes, have serious safety problems, which greatly limit their application. All‐solid‐state batteries (ASSBs) have received extensive attention from large‐scale energy‐storage fields, such as electric vehicles (EVs) and intelligent power grids, due to their benefits in safety, energy density, and thermostability. As the key component of ASSBs, solid electrolytes determine the properties of ASSBs. In past decades, various kinds of solid electrolytes, such as polymers and inorganic electrolytes, have been explored. Among these candidates, organic–inorganic composite solid electrolytes (CSEs) that integrate the advantages of these two different electrolytes have been regarded as promising electrolytes for high‐performance ASSBs, and extensive studies have been carried out. Herein, recent progress in organic–inorganic CSEs is summarized in terms of the inorganic component, electrochemical performance, effects of the inorganic ceramic nanostructure, and ionic conducting mechanism. Finally, the main challenges and perspectives of organic–inorganic CSEs are highlighted for future development.
Physical fitness and neurocognitive outcomes in adult survivors of childhood acute lymphoblastic leukemia: A report from the St. Jude Lifetime cohort
Authors: Phillips Nicholas S. , Howell Carrie R. , Lanctot Jennifer Q. , Partin Robyn E. , Pui Ching‐Hon , Hudson Melissa M. , Robison Leslie L. , Krull Kevin R. , Ness Kirsten K. 
Published: October 2019

BackgroundSurvivors of childhood acute lymphoblastic leukemia (ALL) are at increased risk for both treatment‐related exercise intolerance and neurocognitive deficits. This analysis aimed to identify the association between exercise intolerance and neurocognitive impairments in ALL survivors.MethodsCardiopulmonary exercise testing, results from a 2‐hour standardized neuropsychological assessment, and self‐report questionnaires were obtained for 341 adult survivors of childhood ALL and 288 controls. Multivariable modeling was used to test associations between oxygen uptake at 85% estimated heart rate (rpkVO2) and neuropsychological test and self‐reported questionnaire domains, adjusted for sex, age at diagnosis, cranial radiation, anthracycline, and methotrexate exposure and tobacco smoking status.ResultsCompared with controls, survivors had worse rpkVO2 and performance on verbal intelligence, focused attention, verbal fluency, working memory, dominant/nondominant motor speed, visual‐motor speed, memory span, and reading and math measures (all P < .001). In adjusted models, exercise intolerance was associated with decreases in performance of verbal ability, focused attention, verbal fluency, working memory, dominant motor speed, nondominant motor speed, visual‐motor speed, memory span, reading academics, and math academics in survivors.ConclusionThis study demonstrates an association between exercise intolerance and neurocognitive outcomes. Research is needed to determine whether interventions that improve exercise tolerance impact neurocognitive function in ALL survivors.
A barrier optimization framework for NUMA multi‐core system
Authors: Yi ZhengMing , Chen Fei , Yao YiPing 
Published: October 2019

SummaryParallel program performance often critically depends on barrier performance. In modern NUMA multi‐core machines, barrier synchronization performance is significantly affected by cache‐coherence communication between cores, especially when the scale of NUMA systems is large, complex interconnected networks, memory hierarchies, and cache‐coherence protocols make optimization of barrier algorithm hard.We propose a general barrier optimization framework on NUMA multi‐core machines. The framework splits the barrier into three stages: the barrier arrival within a NUMA node, the barrier arrival across the NUMA nodes, and the wakeup, providing an opportunity to optimize the communication pattern and the cache‐line placement in each stage. To reduce remote communication traffic, we introduce a coordinator per NUMA node. In addition, we implement two barrier algorithms based on the framework. Finally, we show the superiority of the barrier algorithms within our framework over other barrier algorithms and show how to translate a barrier algorithm into a performance model to help make an optimal tradeoff design. Experiments were conducted on three NUMA multi‐core platforms and the results show that the barrier algorithm optimized within our framework is sufficient to deliver as good or better performance than state‐of‐art approaches on NUMA multi‐core machines.
Stereochemistry, Stereodynamics, and Redox and Complexation Behaviors of 2,2′‐Diaryl‐1,1′‐Biazulenes
Authors: Tsuchiya Takahiro , Katsuoka Yuka , Yoza Kenji , Sato Hiroyasu , Mazaki Yasuhiro 
Published: October 2019

AbstractInvited for this month's cover are Takahiro Tsuchiya and Yasuhiro Mazaki, and their colleague Yuka Katsuoka, from Kitasato University, Japan, along with collaborators from Bruker Japan (Kenji Yoza) and Rigaku Corporation (Hiroyasu Sato). The cover picture shows the twisted structure of 2,2′‐di(pyridin‐4‐yl)‐1,1′‐biazulenes, which form a 3:3 cyclic complex with PdCl2. The rotation of the bonds at the 1,1′‐positions of the azulene subunits was padlocked by the complexation. Read the full text of the article at 10.1002/cplu.201900262.
How can eDNA contribute in riverine macroinvertebrate assessment? A metabarcoding approach in the Nalón River (Asturias, Northern Spain)
Authors: Fernández Sara , Rodríguez‐Martínez Saúl , Martínez Jose L. , Garcia‐Vazquez Eva , Ardura Alba 
Published: October 2019

AbstractBackgroundBioassessment of rivers is a fundamental method to determine surface water quality. One of the groups most commonly employed as bioindicators of aquatic ecosystems are benthic macroinvertebrates. Their conventional assessment is based on morphological identification and entails several limitations, such as being time‐consuming and requires trained experts for taxonomic identification. The use of genetic tools to solve these limitations offers an alternative way to evaluate rivers status. The use of environmental DNA (eDNA) metabarcoding has increased in recent years for different purposes, but its use in water quality evaluation is yet to be tested. Here, morphological and eDNA based inventories of macroinvertebrates were compared from the same seven sampling sites in the Upper Nalón River Basin (Asturias, Spain).Materials & MethodsHigh‐Throughput Sequencing (HTS) of the cytochrome oxidase subunit 1 (COI) gene was carried out on DNA from water samples using an Ion Torrent platform. Biotic water quality indices were calculated from morphological and molecular data and compared with independent physico‐chemical habitat assessment to validate eDNA based approach.ResultsHighly positive and significant correlation was found between eDNA metabarcoding and morphological methods (Morphological and eDNA indices, r = 0.798, 5 degrees of freedom d.f., P = 0.031;) and a highly significant negative correlation was found between molecular and habitat quality indices (Stress score & eDNA, ρ = ‐0.878 and P = 0.009; Stress score & Visual, ρ = ‐0.949 and P = 0.0002).DiscussionThe similarity of results from the two approaches and the correlation of eDNA metabarcoding data with the habitat quality indices, suggest that eDNA performs as well as conventional methods for calculating biotic indices in this system, positioning eDNA metabarcoding of macroinvertebrate communities to transform how river bioassessment can be achieved.ConclusionThe usefulness of eDNA metabarcoding to assess rivers water quality based on macroinvertebrates assessment has been demonstrated in a dammed river basin.
Simulating bubble dynamics in a buoyant system
Authors: Arai Erin , Villafranco Dorien , Grace Sheryl , Ryan Emily 
Published: October 2019

SummaryMultiphase flows are critical components of many physical systems; however, numerical models of multiphase flows with large parameter gradients can be challenging. Here, two different numerical methods, volume of fluid (VOF) and smoothed particle hydrodynamics (SPH), are used to model the buoyant rise of isolated gas bubbles through quiescent fluids for a range of Bond and Reynolds numbers. The VOF is an Eulerian grid–based method, whereas the SPH is Lagrangian and mesh free. Each method has unique strengths and weaknesses, and a comparison of the two approaches as applied to multiphase phenomena has not previously been performed. The VOF and SPH simulations are compared, verified, and validated. Results using two‐dimensional VOF and SPH simulations are similar to each other and are able to reproduce numerical benchmarks and experimental results for sufficiently large Morton and Reynolds numbers. It is also shown that at low Reynolds numbers, the two methods, SPH and VOF, diverge in the transient regime of the bubble rise. Regimes that require simulations capable of representing three‐dimensional drag are identified as well as regimes in which results from VOF and SPH diverge.
Isolation and identification of lactic acid bacteria with phytase activity from sourdough
Authors: Mohammadi‐Kouchesfahani Matin , Hamidi‐Esfahani Zohreh , Azizi Mohammad Hossein 
Published: October 2019

AbstractWholemeal bread is strongly recommended due to its nutritional value. However, whole‐grain foods contain a high level of phytic acid, an antinutritional factor that decreases the mineral bioavailability. The objective of this study was isolation and identification of lactic acid bacteria with phytase activity to find a suitable starter for bread‐making. Wheat–legume sourdoughs were prepared by the back‐slopping procedure. Lactic acid bacteria were isolated from the sourdough of wheat flour–mung bean, and their phytase activity was tested in the solid and liquid media. Out of the nine phytase‐active isolates in the solid medium, only three isolates produced extracellular phytase in the liquid medium with activity ranging from 16.3 to 53.2 (U/ml). These isolates belonged to species Weissella confusa mk.zh95 and Pediococcus pentosaceus. The highest phytase activity was found for Weissella confusa mk.zh95. Weissella confusa mk.zh95 is considered an interesting source of phytase during cereals and legumes fermentation which improves the bioavailability of minerals.