bluuebunny/crossref_metadata_2025_split huggingface dataset:
Historicizing Extramural Convict Labour: Trajectories and Transitions in Early Modern Europe
Authors: Heinsen Johan 
Published: July 2020

AbstractNew global histories of punishment are steadily decentring the history of punishment and convict labour, challenging traditional conceptions of a linear path towards a single penal modernity and the penitentiary as the telos of its history. Through an exploration of three strands of extramural convict labour emerging in Copenhagen (1558), Ulm (1561), and Almadén (1566), this interpretative essay argues that this challenge can be furthered by taking a view of Europe's own penal history from which the focus is less on origins and more on how the landscape of punishment evolved through a continuous and largely contingent process of assemblage. In this process, a few key elements – labour, displacement, pain, and confinement – were combined and mixed to different effects in specific contexts. Along with that approach comes the need to historicize the process by relating it to other practices of labour coercion, both within the penal field and outside it.
On Motion Planning and Control for Partially Differentially Flat Systems
Authors: Bai Yang , Svinin Mikhail , Magid Evgeni , Wang Yujie 
Published: July 2020

SUMMARYThis paper deals with motion planning and control problems for a class of partially differentially flat systems. They possess a feature that the derivative of the fiber variable can be represented purely by the base variable and its derivatives. Based on this feature, a Beta function-based motion planning algorithm is proposed with less computational cost compared with the optimal control formulation while providing similar system performance. Then, an adaptive controller is constructed through a function approximation technique-based approach. Finally, the feasibility of the proposed motion planning and control algorithms is verified by simulations.
Persson's Merely Possible Persons
Authors: Bykvist Krister , Campbell Tim 
Published: July 2020

AbstractAll else being equal, creating a miserable person makes the world worse, and creating an ecstatic person makes it better. Such claims are easily justified if it can be better, or worse, for a person to exist than not to exist. But that seems to require that things can be better, or worse, for a person even in a world in which she does not exist. Ingmar Persson defends this seemingly paradoxical claim in his latest book, Inclusive Ethics. He argues that persons that never exist are merely possible beings for whom non-existence is worse than existence with a good life. We argue that Persson's argument, as stated in his book, has false premises and is invalid. We reconstruct the argument to make it valid, but the premises remain highly problematic. Finally, we argue, one can make sense of our procreative obligations without letting merely possible beings into the moral club.
Cognitive mechanisms predicting resilient functioning in adolescence: Evidence from the CogBIAS longitudinal study
Authors: Booth Charlotte , Songco Annabel , Parsons Sam , Fox Elaine 
Published: July 2020

AbstractResilience is a dynamic process depicted by better than expected levels of functioning in response to significant adversity. This can be assessed statistically, by taking the residuals from a model of psychological functioning regressed onto negative life events. We report the first study to investigate multiple cognitive factors in relation to this depiction of resilient functioning. Life events, internalizing symptoms, and a range of cognitive risk and protective factors were assessed in a large sample of adolescents (N = 504) across three waves spaced 12–18 months apart. Adolescents who displayed fewer symptoms than expected, relative to negative life events, were considered more resilient. Adolescents who displayed more symptoms than expected, relative to negative life events, were considered less resilient. All cognitive factors were associated with resilient functioning to differing degrees. These included memory bias, interpretation bias, worry, rumination, self-esteem, and self-reported trait resilience. Regression models showed that memory bias was a key factor explaining unique variance in prospective resilient functioning. In a subsequent cross-lagged panel model, memory bias and resilient functioning were reinforcing mechanisms across time points, supporting cognitive models of emotional resilience. This study adds to the literature, by highlighting key cognitive mechanisms as potential intervention targets
Elucidation of genetic diversity base in Calotropis procera – a potentially emerging new fibre resource
Authors: Majeed Aasim , Goel Bhawana , Mishra Vandana , Kohli Ravinder , Bhardwaj Pankaj 
Published: July 2020

AbstractCalotropis procera is emerging as a new, yet undomesticated, resource of fibre comparable to cotton and kapok. Screening of efficient genotypes from its wild populations would be a useful pre-domestication process. The desired genotypes can then be improved through conventional breeding programmes to develop a domesticated variety. Molecular markers play a major role in modern breeding systems. Thus, an efficient marker resource for C. procera would prove useful in germplasm selection during breeding programmes. In this study, we undertook an initial step of Simple sequence repeats (SSR) marker development for C. procera, which could be applied for germplasm selection. Furthermore, using the developed markers, we assessed the genetic diversity base within its wild populations which could be useful to identify the hotspot areas of germplasm collection. Out of 94,636 de novo assembled transcripts, 9148 sequences were found to contain 12,884 SSRs at a density of 5.5 SSRs/Mb. Twelve SSRs were found as polymorphic with a mean polymorphic information content of 0.575. We observed a moderate level of genetic diversity (Na = 3.625, Ho = 0.58) in the studied populations. Mantel's test showed significant correlation between the geographic distance and the genetic distance (r = 0.147, P = 0.010). Sirsa was found as a genetically most diverse population followed by Barnala while Gurdaspur was found with the least genetic diversity. These genetically diverse populations can serve as an important resource for effective germplasm collection for breeding programmes.
Survey of organic sweet corn growers identifies corn earworm prevalence, management and opportunities for plant breeding
Authors: Moore Virginia M. , Tracy William F. 
Published: July 2020

AbstractCorn earworm (Helicoverpa zea) is one of the most important pests in organic sweet corn (Zea mays) production. Breeding of corn earworm-resistant varieties has been identified as a potential approach to deal with this pest, but it is critical that plant breeding efforts reflect the contexts and needs of organic producers who might eventually adopt earworm-resistant varieties. In November–December 2017, we surveyed organic sweet corn producers in the U.S. to learn about impacts of corn earworm on organic sweet corn production, how producers are currently managing the pest and opportunities for plant breeding to reduce its overall impact. The survey confirmed that corn earworm is the most challenging insect pest for organic sweet corn producers, that current management options remain limited and that earworm-resistant varieties could improve the ability of growers to consistently produce damage-free sweet corn and to improve the value of sweet corn within organic operations.
Treating social anxiety disorder remotely with cognitive therapy
Authors: Warnock-Parkes Emma , Wild Jennifer , Thew Graham R. , Kerr Alice , Grey Nick , Stott Richard , Ehlers Anke , Clark David M. 
Published: July 2020

Abstract
Remote delivery of evidence-based psychological therapies via video conference has become particularly relevant following the COVID-19 pandemic, and is likely to be an on-going method of treatment delivery post-COVID. Remotely delivered therapy could be of particular benefit for people with social anxiety disorder (SAD), who tend to avoid or delay seeking face-to-face therapy, often due to anxiety about travelling to appointments and meeting mental health professionals in person. Individual cognitive therapy for SAD (CT-SAD), based on the Clark and Wells (1995) model, is a highly effective treatment that is recommended as a first-line intervention in NICE guidance (NICE, 2013). All of the key features of face-to-face CT-SAD (including video feedback, attention training, behavioural experiments and memory-focused techniques) can be adapted for remote delivery. In this paper, we provide guidance for clinicians on how to deliver CT-SAD remotely, and suggest novel ways for therapists and patients to overcome the challenges of carrying out a range of behavioural experiments during remote treatment delivery.

Key learning aims

(1)
To learn how to deliver all of the core interventions of CT-SAD remotely.

(2)
To learn novel ways of carrying out behavioural experiments remotely when some in-person social situations might not be possible.
Magnetic Difference Between Deep and Surface Soil Within an Agricultural Area in Southern China: Implications for Magnetic Mineral Transformation During Pedogenic Process Under Subtropical Climate
Authors: Ouyang Tingping , Li Mingkun , Guo Yu , Peng Shasha , He Chenjian , Zhu Zhaoyu 
Published: July 2020

AbstractMineral magnetism is proved as a sensitive method of pedogenesis by numerous studies. However, formation pathways of magnetic minerals and subsequent magnetic response are quite different under different climate. In order to improve the understanding of magnetic assemblages in paddy soil layers in relation to soil formation conditions, a systematic magnetic investigation was performed for surface and its corresponding deep soil collected from 70 sampling sites within a paddy soil area under subtropical climate, south China. Rock magnetic results showed that superparamagnetic, single‐domain, and multiple domain maghematite and hematite were produced during ferrallitization pedogenic processes. Some fine superparamagnetic and single‐domain ferrimagnetic particles were dissolved during late gleyization of paddy soil formation with increased organic matter and reductive condition. As a result, magnetism of surface soil was weaker than that of deep soil despite basically consistent magnetic mineral composition.
Covariant Giant Gaussian Process Models With Improved Reproduction of Palaeosecular Variation
Authors: Bono Richard K. , Biggin Andrew J. , Holme Richard , Davies Christopher J. , Meduri Domenico G. , Bestard Jack 
Published: July 2020

AbstractA commonly used family of statistical magnetic field models is based on a giant Gaussian process (GGP), which assumes each Gauss coefficient can be realized from an independent normal distribution. GGP models are capable of generating suites of plausible Gauss coefficients, allowing for palaeomagnetic data to be tested against the expected distribution arising from a time‐averaged geomagnetic field. However, existing GGP models do not simultaneously reproduce the distribution of field strength and palaeosecular variation estimates reported for the past 10 million years and tend to underpredict virtual geomagnetic pole (VGP) dispersion at high latitudes unless trade‐offs are made to the fit at lower latitudes. Here we introduce a new family of GGP models, BB18 and BB18.Z3 (the latter includes non‐zero‐mean zonal terms for spherical harmonic degrees 2 and 3). Our models are distinct from prior GGP models by simultaneously treating the axial dipole variance separately from higher degree terms, applying an odd‐even variance structure, and incorporating a covariance between certain Gauss coefficients. Covariance between Gauss coefficients, a property both expected from dynamo theory and observed in numerical dynamo simulations, has not previously been included in GGP models. Introducing covariance between certain Gauss coefficients inferred from an ensemble of “Earth‐like” dynamo simulations and predicted by theory yields a reduced misfit to VGP dispersion, allowing for GGP models which generate improved reproductions of the distribution of field strengths and palaeosecular variation observed for the last 10 million years.
Distribution of Earthquakes on a Branching Fault System Using Integer Programming and Greedy‐Sequential Methods
Authors: Geist Eric L. , Parsons Tom 
Published: July 2020

AbstractA new global optimization method is used to determine the distribution of earthquakes on a complex, connected fault system. The method, integer programming, has been advanced in the field of operations research but has not been widely applied to geophysical problems until recently. In this application, we determine the optimal distribution of earthquakes on mapped faults to minimize the global misfit in slip rates for multifault ruptures. Integer programming solves for a decision vector composed of every possible location that a sample of earthquakes can occur on every fault, subject to slip rate uncertainty constraints. Step over connections are straightforward to include, whereas branching fault connections are not. To include branching ruptures, we distinguish between individual multifault rupture paths, as opposed to formulating the integer programming problem based on individual faults as in previous studies. The new method is applied to the complex fault system in the San Francisco Bay Area as a case study. Results from the integer programming method are compared to those from a local optimization method, termed the greedy‐sequential method. Several experiments using these two methods indicate that shape of the on‐fault magnitude distributions and which branching faults are involved in multifault ruptures depend on how much emphasis is placed on fitting the target slip rate. In cases where the underlying data are not strong enough to warrant chasing the target slip rate, it is better to focus on the distribution of feasible results that better represents the uncertainty in the solutions imposed by the data.
Longitudinal Responses of the Equatorial/Low‐Latitude Ionosphere Over the Oceanic Regions to Geomagnetic Storms of May and September 2017
Authors: Akala A. O. , Oyeyemi E. O. , Amaechi P. O. , Radicella S. M. , Nava B. , Amory‐Mazaudier C. 
Published: July 2020

AbstractThis study presents the longitudinal dependence of responses of the equatorial/low‐latitude ionosphere over the oceanic regions to geomagnetic storms of 28 May and 8 September 2017. We investigated the interplanetary origins of the storms. Total electron content (TEC) data were obtained from Global Navigation Satellite System stations, located around the oceanic areas in the equatorial/low‐latitude regions. The Rate of change of TEC Index (ROTI) was used as a proxy for ionospheric irregularities over the study locations. Further, variations of the horizontal component of the Earth's magnetic fields, obtained from ground‐based magnetometers were studied. We used ionospheric disturbance currents, polar cap and auroral electrojet indices to monitor the storm time electric fields. The May 2017 storm was driven by sheath and magnetic cloud fields, while the September 2017 storm was driven by sheath fields. We observed a comparative dominance of TEC intensities over the Oceans than over the landlocked areas. Empirically, our results validated a theoretical suggestion of the existence of a dynamic ocean‐ionosphere coupling made by Godin et al. (2015, http://10.0.4.162/s40623-015-0212-4). Prompt Penetration Electric Fields (PPEF) was observed to be a key factor that controls TEC responses to storms. PPEFs caused TEC enhancements, mainly over the Pacific Ocean longitudes during the May 2017 storm and enhanced TEC over the Atlantic Ocean and the Pacific Oceans longitudes during the September 2017 storm. These PPEFs triggered irregularities over the Pacific Ocean longitudes, particularly during the main phase of May 2017 storm. Irregularities were generally inhibited by the September 2017 storm.
Nanoparticle meta-grid for enhanced light extraction from light-emitting devices
Authors: Sikdar Debabrata , Pendry John B. , Kornyshev Alexei A. 
Published: July 2020

AbstractBased on a developed theory, we show that introducing a meta-grid of sub-wavelength-sized plasmonic nanoparticles (NPs) into existing semiconductor light-emitting-devices (LEDs) can lead to enhanced transmission of light across the LED-chip/encapsulant interface. This results from destructive interference between light reflected from the chip/encapsulant interface and light reflected by the NP meta-grid, which conspicuously increase the efficiency of light extraction from LEDs. The “meta-grid”, should be inserted on top of a conventional LED chip within its usual encapsulating packaging. As described by the theory, the nanoparticle composition, size, interparticle spacing, and distance from the LED-chip surface can be tailored to facilitate maximal transmission of light emitted from the chip into its encapsulating layer by reducing the Fresnel loss. The analysis shows that transmission across a typical LED-chip/encapsulant interface at the peak emission wavelength can be boosted up to ~99%, which is otherwise mere ~84% at normal incidence. The scheme could provide improved transmission within the photon escape cone over the entire emission spectrum of an LED. This would benefit energy saving, in addition to increasing the lifetime of LEDs by reducing heating. Potentially, the scheme will be easy to implement and adopt into existing semiconductor-device technologies, and it can be used separately or in conjunction with other methods for mitigating the critical angle loss in LEDs.
Long-term treatment with a glucagon-like peptide-1 receptor agonist reduces ethanol intake in male and female rats
Authors: Vallöf Daniel , Kalafateli Aimilia Lydia , Jerlhag Elisabet 
Published: July 2020

AbstractGiven the limited efficacy of available pharmacotherapies for treatment of alcohol use disorder (AUD), the need for new medications is substantial. Preclinical studies have shown that acute administration of glucagon-like peptide-1 receptor (GLP-1R) agonists inhibits various ethanol-related behaviours, indicating this system as a potential target for AUD. However, the effects of long-term systemic treatment of GLP-1R agonists on ethanol intake in male and female rodents are to date unknown. Therefore, we investigated the effects of 9 or 5 weeks of once weekly administration of dulaglutide, a long-acting GLP-1R agonist, on ethanol intake in male and female rats. The ethanol intake during treatment discontinuation was also monitored. In an initial attempt to identify preliminary underlying mechanisms, the effects of 9 weeks of once weekly dulaglutide treatment on monoaminergic signalling in reward-related areas were explored in both sexes. We found that 9 or 5 weeks of once weekly dulaglutide treatment reduced ethanol intake and preference in male and female rats. Following discontinuation of dulaglutide treatment, the decrease in ethanol consumption was prolonged in males, but not females. We demonstrated that 9 weeks of dulaglutide treatment differentially influenced monoaminergic signalling in reward-related areas of male and female rats. Collectively, these data imply that the GLP-1R attracts interest as a potential molecular target in the medical treatment of AUD in humans: more specifically, dulaglutide should be evaluated as a potential medication for treatment thereof.
Host immune genetic variations influence the risk of developing acute myeloid leukaemia: results from the NuCLEAR consortium
Authors: Sánchez-Maldonado J. M. , Campa D. , Springer J. , Badiola J. , Niazi Y. , Moñiz-Díez A. , Hernández-Mohedo F. , González-Sierra P. , Ter Horst R. , Macauda A. , Brezina S. , Cunha C. , Lackner M. , López-Nevot M. A. , Fianchi L. , Pagano L. , López-Fernández E. , Potenza L. , Luppi M. , Moratalla L. , Rodríguez-Sevilla J. J. , Fonseca J. E. , Tormo M. , Solano C. , Clavero E. , Romero A. , Li Y. , Lass-Flörl C. , Einsele H. , Vazquez L. , Loeffler J. , Hemminki K. , Carvalho A. , Netea M. G. , Gsur A. , Dumontet C. , Canzian F. , Försti A. , Jurado M. , Sainz J. 
Published: July 2020

AbstractThe purpose of this study was to conduct a two-stage case control association study including 654 acute myeloid leukaemia (AML) patients and 3477 controls ascertained through the NuCLEAR consortium to evaluate the effect of 27 immune-related single nucleotide polymorphisms (SNPs) on AML risk. In a pooled analysis of cohort studies, we found that carriers of the IL13rs1295686A/A genotype had an increased risk of AML (PCorr = 0.0144) whereas carriers of the VEGFArs25648T allele had a decreased risk of developing the disease (PCorr = 0.00086). In addition, we found an association of the IL8rs2227307 SNP with a decreased risk of developing AML that remained marginally significant after multiple testing (PCorr = 0.072). Functional experiments suggested that the effect of the IL13rs1295686 SNP on AML risk might be explained by its role in regulating IL1Ra secretion that modulates AML blast proliferation. Likewise, the protective effect of the IL8rs2227307 SNP might be mediated by TLR2-mediated immune responses that affect AML blast viability, proliferation and chemorresistance. Despite the potential interest of these results, additional functional studies are still warranted to unravel the mechanisms by which these variants modulate the risk of AML. These findings suggested that IL13, VEGFA and IL8 SNPs play a role in modulating AML risk.
The integrated stress response induces R-loops and hinders replication fork progression
Authors: Choo Josephine Ann Mun Yee , Schlösser Denise , Manzini Valentina , Magerhans Anna , Dobbelstein Matthias 
Published: July 2020

AbstractThe integrated stress response (ISR) allows cells to rapidly shutdown most of their protein synthesis in response to protein misfolding, amino acid deficiency, or virus infection. These stresses trigger the phosphorylation of the translation initiation factor eIF2alpha, which prevents the initiation of translation. Here we show that triggering the ISR drastically reduces the progression of DNA replication forks within 1 h, thus flanking the shutdown of protein synthesis with immediate inhibition of DNA synthesis. DNA replication is restored by compounds that inhibit eIF2alpha kinases or re-activate eIF2alpha. Mechanistically, the translational shutdown blocks histone synthesis, promoting the formation of DNA:RNA hybrids (R-loops), which interfere with DNA replication. R-loops accumulate upon histone depletion. Conversely, histone overexpression or R-loop removal by RNaseH1 each restores DNA replication in the context of ISR and histone depletion. In conclusion, the ISR rapidly stalls DNA synthesis through histone deficiency and R-loop formation. We propose that this shutdown mechanism prevents potentially detrimental DNA replication in the face of cellular stresses.