bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute exogenous intoxications and homocysteine
Authors: Tufkova Stoilka , Paskaleva Diana , Sandeva Milena 
Published: September 2020

Inroduction: Oxidative stress is an important pathogenetic factor in a number of socially significant diseases, including the acute exogenous poisoning. Homocysteine is a sulfur-containing amino acid synthesized on the basis of methionine, which plays an important role as an oxidizing agent in the human body. As such a factor, it was the monitored subject of this study.
Aim: To measure the level of homocysteine in acute exogenous poisoning with alcohol, heroin and cerebro-toxic drugs.
Materials and methods: This is a prospective longitudinal study including 118 patients with moderate or severe acute poisoning with cerebro-toxic drugs (n=45), alcohol (n=40), heroin (n=33) and a &ldquo;control group&rdquo; (n=35). Clinical laboratory tests were performed according to the standards of a clinical laboratory. In the statistical analysis we used alternative and variance analysis, parametric methods for hypothesis assessment, and nonparametric methods for normal distribution.
Results and discussion: The results showed that for the three groups of intoxications, the average homocysteine levels were higher than those of the control group (&#1088;<0.001). The intergroup comparison criterion for normal distribution showed that the changes in patients with alcohol intoxication (u=3.39; &#1088;<0.001) and heroin intoxication (u=2.00; &#1088;<0.001) were highly statistically significant without correlating with the severity of the poisoning (&#1088;>0.05).
Conclusion: There is a risk of oxidative stress in intoxication with alcohol and narcotics. A reliable marker for the complex evaluation of oxidative stress in people is monitoring the serum level of homocysteine and its careful interpretation.
Assessment of Children Exposed to Maras Powder Intoxication
Authors: Dalkiran Tahir , Özaslan Mehmed Mustafa , Acipayam Can , Kandur Yaşar , Unsal Velid 
Published: September 2020

Introduction: A smokeless tobacco known as Maras powder (MP) is commonly consumed in the southern region of Turkey. To the extent of our knowledge, no previous study in literature has reported acute MP intoxication in children.
Aim: Our aim was to determine the clinical effects and treatment strategies of MP poisoning in children.Materials and methods: We retrospectively reviewed the medical records of children <18 years of age with MP intoxication who were followed up in the Intensive Care Unit between January 2016 and April 2018 in our center.
Results: Forty-one patients (M/F= 25/16) were included in this study. The mean age was 13.2&plusmn;22.4 months (age range: 7 to 30 months). The patients presented with vomiting (n=23, 56%), cough (n=17, 41.5%), loss of consciousness (n=11, 26.8%), respiratory distress (n=6, 14.6%), convulsion (n=7, 17%), cyanosis (n=1, 2.4%), and abdominal pain (n=1, 2.4%) following oral ingestion of the substance. On their physical examination all patients with convulsion were in a comatose state. Thirty-two patients (78%) had tachycardia; 15 patients (36.5%) had pharyngeal hyperemia; and three (7.3%) had hiccups. Although the female patients had a lesser rate of symptoms than male patients, the difference was not statistically significant.
Conclusions: Our aim was to inform the doctors about the clinical picture that develops after taking this substance and contribute to the understanding of the treatment approach.
Non-hematopoietic erythropoietin-derived peptides for atheroprotection and treatment of cardiovascular diseases
Authors: Belyaeva Veronika S. , Stepenko Yulia V. , Lyubimov Igor I. , Kulikov Alexandr L. , Tietze Alesia A. , Kochkarova Indira S. , Martynova Olga V. , Pokopeyko Olga N. , Krupen’kina Liliya A. , Nagikh Andrey S. , Pokrovskiy Vladimir M. , Patrakhanov Evgeniy A. , Belashova Anastasia V. , Lebedev Petr R. , Gureeva Anastasia V. 
Published: September 2020

Relevance: Cardiovascular diseases continue to be the leading cause of premature adult death.
Lipid profile and atherogenesis: Dislipidaemia leads to subsequent lipid accumulation and migration of immuno­competent cells into the vessel intima. Macrophages accumulate cholesterol forming foam cells – the morphological substrate of atherosclerosis in its initial stage.
Inflammation and atherogenesis: Pro-inflammatory factors provoke oxidative stress, vascular wall damage and foam cells formation.
Endothelial and mitochondrial dysfunction in the development of atherosclerosis: Endothelial mitochondria are some of the organelles most sensitive to oxidative stress. Damaged mitochondria produce excess superoxide and H2O2, which are the main factors of intracellular damage, further increasing endothelial dysfunction.
Short non-hematopoietic erythropoietin-based peptides as innovative atheroprotectors: Research in recent dec­ades has shown that erythropoietin has a high cytoprotective activity, which is mainly associated with exposure to the mitochondrial link and has been confirmed in various experimental models. There is also a short-chain derivative, the 11-amino acid pyroglutamate helix B surface peptide (PHBSP), which selectively binds to the erythropoietin hetero­dymic receptor and reproduces its cytoprotective properties. This indicates the promising use of short-chain derivatives of erythropoietin for the treatment and prevention of atherosclerotic vascular injury. In the future, it is planned to study the PHBSP derivatives, the modification of which consists in adding RGD and PGP tripeptides with antiaggregant properties to the original 11-member peptide.
Structure sociale, changements démographiques et transition démocratique au Paraguay
Authors: Ortiz Luis , Labarthe Sunniva 
Published: September 2020

La société paraguayenne, entendue comme structure sociale, présentait durant les dernières années du régime autoritaire d’Alfredo Stroessner (1954-1989) certains traits qui allaient persister au cours des trois décennies qui suivirent le renversement de sa dictature, au cours d’un processus de démocratisation sinueux et difficile. L’un de ces traits, peut-être le plus remarquable, est la fragmentation sociale, en fonction de laquelle les relations entre classes sociales se caractérisent depuis par une tension récurrente autour des ressources et des opportunités. Cette tension prend des formes institutionnelles et territoriales, respectivement, de segmentation et de ségrégation. Ces caractéristiques se sont maintenues structurellement pendant trente ans, changeant cependant de formes et de dimensions, dans une dynamique qui explique en grande partie les limites du régime démocratique dans l’histoire récente du Paraguay, en dépit de cycles oscillants de croissance économique et de stabilité institutionnelle. Cet article se propose de mettre en lumière la convergence de différents processus démographiques et sociaux qui expliquent les changements significatifs de la structure sociale du Paraguay depuis la fin du XX e siècle. Ces évolutions ont principalement été marquées par trois caractéristiques : une transition démographique marquée (et tardive), l’extension de l’accès à l’éducation à toute la population d’âge scolaire et la variation en volume et en proportion des catégories sociales dans la structure sociale. Parmi ces trois changements, les effets de la réforme de l’éducation des années 1990 méritent une attention particulière ; l’un des plus notoires étant la croissance de la classe moyenne urbaine liée au secteur tertiaire, dont l’ascension a atténué le mécontentement face à la persistance des inégalités sociales après trois décennies de démocratisation. De même, l’expansion des catégories sociales intermédiaires a atténué la contradiction entre croissance et concentration des revenus qui s’est traduite par une augmentation de la création de valeur ajoutée aux dépens d’une classe défavorisée, appauvrie et exclue. Afin d’exposer les principaux tenants et aboutissants de ces processus, cette étude se fonde sur des sources secondaires, incluant des données statistiques et des informations bibliographiques.
Non–Cell-Autonomous Activity of the Hemidesmosomal Protein BP180/Collagen XVII in Granulopoiesis in Humanized NC16A Mice
Authors: Lin Lin , Hwang Bin-Jin , Li Ning , Googe Paul , Diaz Luis A. , Miao Ed , Vilen Barbara , Thomas Nancy E. , Ting Jenny , Liu Zhi 
Published: September 2020

Abstract
BP180 (also termed type XVII collagen) is a hemidesmosomal protein and plays a critical role in cell–cell matrix adhesion in the skin; however, its other biological functions are largely unclear. In this study, we generated a BP180 functional–deficient mouse strain by deleting its extracellular domain of humanized NC16A (termed ΔNC16A mice). We found that BP180 is expressed by bone marrow mesenchymal stem cells (BM-MSC), and its functional deficiency leads to myeloid hyperplasia. Altered granulopoiesis in ΔNC16A mice is through bone marrow stromal cells evidenced by bone marrow transplantation. Furthermore, the level of G-CSF in bone marrow and circulation were significantly increased in ΔNC16A mice as compared with wild-type mice. The increased G-CSF was accompanied by an increased activation of the NF-κB signaling pathway in bone marrow and BM-MSC of ΔNC16A mice. Blockade of G-CSF restored normal granulopoiesis in ΔNC16A mice. Inhibition of NF-κB signaling pathway significantly reduces the release of G-CSF from ΔNC16A BM-MSC in vitro and the level of serum G-CSF in ΔNC16A mice. To our knowledge, these findings provide the first direct evidence that BP180 plays an important role in granulopoiesis through regulating NF-κB signaling pathway in BM-MSC.
Does Community- or University-Based Residency Sponsorship Affect Graduate Perceived Preparation or Performance?
Authors: Carek Peter J. , Mims Lisa , Kirkpatrick Stacey , Williams Maribeth P. , Zhang Runzhi , Rooks Benjamin , Datta Susmita , Peterson Lars E. , Mainous Arch G. 
Published: September 2020

ABSTRACT

Background
Residency training occurs in varied settings. Whether there are differences in the training received by graduates of community- or medical school–based programs has been the subject of debate.

Objective
This study examined the perceived preparation for practice, scope of practice, and American Board of Family Medicine (ABFM) board examination pass rates of family physicians in relation to the type of residency program (community, medical school, or partnership) in which they trained.

Methods
Predetermined survey responses were abstracted from the 2016 and 2017 National Family Medicine Graduate Survey of ABFM and linked to data about residency programs obtained from the websites of national organizations. Descriptive statistics were used to summarize the data and logistic regression to examine differences between survey results based on type of residency training: community, medical school, or partnership.

Results
Differences in the perception of preparation as well as current scope of practice were noted for the 3 residency types. The differences in perception were mainly noted in hospital-based skills, such as intubation and ventilator management, and in women's health and family planning services, with different program types increasing preparedness perception in different domains.

Conclusions
In general, graduates of family medicine community-based, non-affiliated, and partnership programs perceived they were prepared for and were providing more of the services queried in the survey than graduates of medical school–based programs.
Family Medicine Faculty Time Allocation and Burnout: A Residency Research Network of Texas Study
Authors: Ko Suk (Steve) , Guck Adam , Williamson Meredith , Buck Katherine , Young Richard ,   Residency Research Network of Texas Investigators
Published: September 2020

ABSTRACT

Background
Burnout among graduate medical education (GME) faculty is a well-documented phenomenon, but few studies have explored the relationship between faculty time allocation and burnout.

Objective
Our objectives were to (1) characterize time allocation of academic family physicians, (2) measure the difference between actual versus preferred time spent on various tasks, and (3) examine this difference in relation to burnout.

Methods
From January to March 2017, family medicine GME faculty across Texas completed anonymous online surveys for burnout (Maslach Burnout Inventory) and occupational stress (Primary Care Provider Stress Checklist). They also reported the percentage of time they actually versus prefer to allocate across 5 categories of tasks: direct patient care, nondirect clinical duties, teaching, administration, and research. Difference scores between actual and preferred time allocation were calculated and correlated with burnout and stress scores.

Results
Of the faculty physicians surveyed, 53% provided complete responses (103 of 195). On average they engaged in their preferred amount of time on direct patient care (30% of their time) and administrative duties (15%). Meanwhile, faculty preferred to increase time spent teaching (37% to 41%, P = .002) and conducting research (4% to 7%, P ≤ .001), while reducing time spent on nondirect clinical duties (14% to 7%, P &lt; .001). Those with higher misalignment in their weekly schedules reported higher levels of professional burnout and occupational stress.

Conclusions
Many family medicine GME faculty spent 20% or more of their time in a manner incongruent with their preferences, which may place them at higher risk for burnout and occupational stress.
Ketepatan Pemberian Obat Oleh Perawat Dipengaruhi Lingkungan Kerja Di Ruang Rawat Inap Rsud Kanujoso Balikpapan
Authors: Feriani Pipit 
Published: September 2020

Lingkungan kerja terdiri dari gaya kepemimpinan dan budaya organisasi.Gaya kepemimpinan merupakan cara pimpinan untuk mempengaruhi orang lain. Sedangkan Budaya organisasi diyakini juga merupakan faktor penentu terhadap kesuksesan kinerja yang memeliki keterkaitan dengan kulaitis pelayanan. Kualitas pelayanan rumah sakit dapat dilihat dari kecepatan pelayanan, keramahan, efektifitas tindakan, serta kondisi yang dapat menciptakan kenyamanan bagi pasien dan pengunjung. Salah satu bentuk kualitas ini diukur dari ketepatan dalam tindakan pemberian obat. Six rights dalam pemberian obat meliputi tepat klien, obat, dosis, waktu, cara/rute dan ditambah dengan tepat dokumentasi agar tidak terjadi medication error. Hasil uji Chi-Square gaya kepeminpinan dan b budaya organisasai diperoleh nilai p (0,003; 0,001). artinya terdapat pengaruh gaya kepemimpinan dan budaya organisasi dengan dengan ketepatan pemberian obat.
A festa das letras: uma alfabetização possível
Authors: Pereira Neli Aparecida Gai , Queiróz Sandy Carla Fernandes de 
Published: September 2020

O presente estudo discute como a Festa das Letras pode auxiliar no processo de formação docente, assim como, no processo de alfaletrar e de aprendizagem. Com o objetivo de formar alfabetizadores críticos e preparados para atuar na Educação Básica, a Universidade do Oeste de Santa Catarina possibilita aos acadêmicos uma formação de qualidade. O curso de Pedagogia desenvolve, na disciplina de Alfabetização e Letramento II, uma nova estratégia para que as crianças aprendam a ler e escrever de forma lúdica, de cunho sistematizado e científico, intitulado “Festa das Letras”. A Festa das Letras apresenta metodologias diferenciadas para o processo de alfaletrar, dentre elas: rimas, história da escrita, história do alfabeto, canto, além de um ambiente alfabetizador. A sistemática foi desenvolvida com vários grupos de crianças, com idade entre 05 e 09 anos. A Festa das Letras pode ser utilizada na alfabetização e letramento com crianças de todos os lugares, além de auxiliar na apropriação do processo de leitura e escrita, fatores indispensáveis para o desenvolvimento cognitivo e social das crianças.
Um novo amanhecer através da arteterapia... Resgatando relacionamentos, após a mastectomia
Authors: Brando Maria Carolina Monteiro Machado de Souza 
Published: September 2020

O objetivo deste trabalho visou o relacionamento conjugal de mulheres mastectomizadas.
Levando em conta os aspectos socioculturais brasileiros, observamos que mulheres mastectomizadas apresentavam muitos problemas de relacionamento com seus companheiros quanto à sexualidade, intimidade e imagem corporal, especialmente em classes sociais mais baixas.
Foi elaborado um workshop de arteterapia onde foram convidados seus maridos ou companheiros. Foi um trabalho piloto que implantamos através de uma ONG que trabalhava com a prevenção do câncer de mama na América Latina.
Trabalhamos com um grupo de classe social baixa em um cidade litorânea do Estado de São Paulo. No início, os homens apresentaram certa resistência. Entretanto, um dos pontos culminantes do workshop foi o depoimento dos maridos/companheiros que participaram do evento. Participaram ativamente com suas esposas e apresentaram seus trabalhos ao grupo de maneira afetiva e emocional. As mulheres mostraram-se extremamente surpresas com essa reação masculina.
Trabalhamos através da música, da expressão corporal, histórias, desenhos, além de um processo de confraternização.
Através do processo criativo, conseguimos atingir nossa meta. Os homens tiveram a oportunidade de se expressarem através das imagens, autentica e espontaneamente, e com o tempo essa experiência pode leva-los a uma melhor visão de si mesmos, assim como uma provável reparação e transformação emocional, além de ajudarem suas esposas na recuperação após um câncer de mama. Utilizamos também elementos informativos, introduzindo pela primeira vez uma visão dos sentimentos femininos e masculinos após o diagnóstico de câncer de mama.
Obtivemos um resultado bastante positivo ao recebermos pedidos dos participantes para que implantássemos um novo workshop dando continuidade ao trabalho começado.
O processo criativo tem se mostrado muito eficiente em trabalhos dentro da área da saúde. Sendo a comunicação de maneira simbólica, a arte facilita novos entendimentos e insights. Ajuda na resolução de conflitos, solução de problemas e formulação de novas percepções que o conduzirão a mudanças positivas, crescimento e cura.
Pengembangan Bahan Cerita Tentang Pengorbanan Yesus Kristus di Kayu Salib dalam Pembelajaran Pendidikan Agama Kristen
Authors: 25 Lisbet Panggabean 
Published: September 2020

Kata Kunci: Pengembangan, Bahan Cerita Abstract: This study aims to development a product in the form of a story about the Sacrifice of Jesus Christ on the Cross on the subject of 5 th grade Christian Religious Education in the State Elementary School in Tarutung District 2019/2020 Academic Year. This research is a research and development (Research and Development RD). The results of the needs analysis showed that the respondents of the Trial study consisted of 20 PAK Teachers and several validations from theologians, linguists and method experts on the story method in learning Christian Religious Education with the material Sacrifice of Jesus Christ on the Cross. The results of the study concluded that the PAK teacher strongly agreed that the material about the Sacrifice of Jesus Christ on the Cross was taught using the story method, and strongly agreed that the story material was developed by the researcher. Because there is no reference (story) about the Sacrifice of Jesus Christ on the Cross. The results of the analysis of the researchers material product stories about the sacrifice of Jesus Christ.Keyword: Development, Story Material.
PENGARUH PENGAJARAN REMEDIAL TERHADAP HASIL BELAJAR PENDIDIKAN AGAMA KRISTEN (PAK) PADA SISWA KELAS XI SMK NEGERI 1 LAGUBOTI TAHUN PEMBELAJARAN 2019/2020
Authors: Nababan Tulus Delima Meilita 
Published: September 2020

This study aims to determine the level of remedial teaching achievement, the level of learning outcomes before remedial and the level of PAK learning outcomes of students in SMK Negeri 1 Laguboti in the 2019/2020 academic year, as well as to determine the positive and significant influence between remedial teaching on the learning outcomes of PAK XI grade students of XI SMK Negeri 1 Laguboti 2019/2020 academic year. The hypothesis of this study is: there is a positive and significant influence of remedial teaching on the learning outcomes of PAK XI grade students of SMK Negeri 1 Laguboti 2019/2020 academic year. Researchers used quantitative inferential statistical research. The population in this study amounted to 105 people and a sample of 51 people. The research instrument used was a closed questionnaire and tests.The conclusions of this study were the level of remedial teaching achievement of 64.924% with a good scale range, the level of achievement of learning outcomes before remedial to students amounted to 59.51 with the completion criteria or 70, and the level of learning outcomes after learning remedial for students is 82.12 with naotas criteria or 70. And the positive relationship test results obtained value of 0.418 tute 0.297. The result of simple linear equation is Y-62.239 + 0.303, with tnne lutei value (3,260 1,684) and futur fme value (10,626 4,08) so that it can be collected that the hypothesis is accepted.Keywords: Remedial Teaching, Student PAK Learning outcomes
PENGARUH KOMUNIKASI DALAM KELUARGA KRISTEN TERHADAP MORAL REMAJA GKPI DUMA SIRISIRISI KECAMATAN DOLOKSANGGUL TAHUN 2019
Authors: Silaban Angga Andika 
Published: September 2020

The research aimsto figure out how positive and significant a communication in Christian family towards adolescent moral of GKPI Duma Sirisirisi Kecamatan Doloksanggul 2019.The research hyphotesis : there is an positive effect and significant communication in Christian family towards adolescent moral of GKPI Duma Sirisirisi Kecamatan Doloksanggul 2019. This research is a study of population using descriptive method. Population is the whole adolescent of GKPI Duma Sirisirisi 2019 and the sum is 35 people. The instrument of this research is a questionnaire. The result of this analysis r hitung = 0,745 r tabel = 0,334and thitung= 6,415 t tabel = 2,034 shows that there is an effect amongst communication in Christian family towards adolescent moral of GKPI Duma Sirisirisi Kecamatan Doloksanggul 2019 and it obtains a significance of simple regression equations that is Ý = 15,523+ 0.848X. Hyphotesis testing obtains F hitung= 41,220F tabel = 1,97 then Ho is refused and Ha is accepted. This research concludes that the effect of communication in Christian family towards adolescent moral of GKPI Duma Sirisirisi Kecamatan Doloksanggul 2019 and it is 55,5% . Related to the result of this research, the writer gives such a suggestion for the observers particularly addressed to “parents” to carry on a communication in a family circle in order to create a good moral of adolescent ChristianKeywords : Communication in Christian family, adolescent moral