bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reflexiones sobre la producción arquitectónica Premium del turismo residencial en Punta del Este, Uruguay
Authors: Russo Cardozo Fiorella 
Published: December 2020

La siguiente investigación centra su atención en la realidad del Uruguay post-crisis financiera de principios de siglo XXI -año 2002-. Frente a la depresión que se vivió en ese momento en la región nos interesa el impulso que el país toma para su recuperación, lanzándose a nuevos mercados extraregionales, con el fin de reactivar la industria de la construcción y promover el desarrollo inmobiliario de nuevos productos. De cara a esta situación tres ciudades cobran relevancia en el territorio uruguayo: Montevideo, Colonia y Punta del Este. En tal contexto, Punta del Este representa uno de los vitales polos de inversión y desarrollo. La región sur del país, integrada por dichas ciudades, conforma un sector del eje metropolitano del Cono Sur ubicado sobre la costa atlántica desde Buenos Aires hasta San Pablo. Esta área es la más internacionalizada y globalizada del territorio uruguayo y ofrece un gran potencial de desarrollo futuro, exponiéndose notoriamente a grandes transformaciones, especialmente Maldonado-Punta del Este como centro dinámico y privilegiado del turismo internacional, y Colonia debido a su paulatina integración a la dinámica metropolitana de Buenos Aires así como por su alto nivel de calidad de vida.
Desde los años 70, momento en que el balneario turístico consolidó gran parte de su infraestructura edilicia -fundamentalmente residencial-, no se habíavuelto a vivir tanto optimismo en cuanto al desarrollo inmobiliario y turístico en Punta del Este. Es a partir del año 2005, pasado ciertamente el letargo de lacrisis, que la ciudad toma fuerza e instaura su récord histórico en cuanto a las autorizaciones otorgadas por parte de las administraciones locales para laconstrucción de 800.000 metros cuadrados, inversión que se valora en 500.000.000 de dólares, procedente en su mayoría de capitales internacionales extraregionales.
Acceptability of HIV Screening in a Sample of International Students in the United States
Authors: Ayosanmi Oluwasola Stephen , Oden Lorette , Ayosanmi Titilope , Alli Babatunde Y. , Wen Mei , Johnson Jamie 
Published: December 2020

Background and Objectives: HIV transmission from persons unaware of their HIV status occurs more commonly than those who are aware of their status. Knowledge of one’s HIV status may encourage preventive behaviors. Anecdotal evidence suggests that many international students may be willing to accept HIV screening, but empirical evidence to support this claim is lacking. We sought to determine the willingness of international students in the United States (US) to accept HIV screening, if offered.
Methods: We conducted a cross-sectional study using an online survey of international students at Western Illinois University, USA. The independent variable was the sociodemographic data of our participants; the dependent variable was the acceptance of HIV screening. The covariates were knowledge about HIV and the factors associated with the acceptance of the screening. Descriptive statistics and multivariate analysis were conducted.
Results: A total of 185 respondents out of 491 students participated in the online survey. Of these, 107 (57.8%) were males, and 78 (42.8%) were females. Most of the respondents were from Asian countries (64.9%) and African countries (24.9%). The prevalence of acceptance of HIV screening was 74%. Among participants willing to accept screening, if offered, 90% perceived screening would be beneficial to their health. Meanwhile, 83% of those who would refuse the screening were not sexually active.
Conclusion and Global Health Implications: Many international students may be interested in getting HIV screening if offered. Awareness of the benefits of HIV screening may influence the decision to screen. Findings may inform further studies that will lead to policy formulations for the health of international students in the US.
Key words: • HIV Screening • HIV Acceptability • International Students • College Students

Copyright © 2020 Ayosanmi et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) which permits unre-stricted use, distribution, and reproduction in any medium, provided the original work, first published in this journal, is properly cited.
Sources of Perennial Water Supporting Critical Ecosystems, San Pedro Valley, Arizona
Authors: Eastoe Christopher J. 
Published: December 2020

ABSTRACTStable O and H isotope data distinguish three sources for base flow in five reaches of the San Pedro River: (A) base flow and sub-flow from upstream reaches of the river; (B) bank storage derived from summer monsoon floodwater; and (C) water from the mountainous flanks of the river catchment. A and C support base flow in the sub-basin upstream of Sierra Vista. A, B, and C combine to support base flow near St. David. Source C in this area is ancient deep-basin groundwater. Source C dominates in Cascabel near Benson Narrows, with downstream additions from A. In Cascabel near Gamez Road, sources A and C combined to support base flow that had disappeared by 2019. Near Redington, source C appears to have operated through a limestone aquifer vulnerable to short-term drought. Groundwater sub-basins separated by impermeable sills in the riverbed are evolving into hydrologically separate sub-basins as base flow across the sills decreases. The decrease in base flow partly reflects regional long-term drought, which has been exacerbated by pumping. Additional groundwater demand from urban growth upstream of Benson is likely to cause further decline of base flow near St. David and Sierra Vista.
A Dual-Fluorescence Labeling Pseudovirus for Real-Time Imaging of Single SARS-CoV-2 Entry in Respiratory Epithelial Cells
Authors: Ma Yingxin , Mao Guobin , Wu Guoqiang , Chen Minghai , Qin Fujun , Zhang Xian-En 
Published: December 2020

Abstract
The pseudovirus strategy makes studies of highly pathogenic viruses feasible without the restriction of high-level biosafety facility, thus greatly contributing to virology and being used in research of SARS-CoV-2. Here, we generated a dual-color pseudo-SARS-CoV-2 virus using an HIV-1 pseudovirus production system and the SARS-CoV-2 spike (S) glycoprotein, of which the membrane was labeled with lipophilic dye (DiO) and the genomic RNA-related viral protein R (Vpr) of the viral core were fused with mCherry. With this dual-color labeling strategy, not only the movement of the whole virus but also the fate of the labeled components can be traced. The pseudovirions were applied to track viral entry at a single particle level in four types of the human respiratory cells: nasal epithelial cells (HNEpC), pulmonary alveolar epithelial cells (HPAEpiC), bronchial epithelial cells (BEP-2D), and oral epithelial cells (HOEC). Pseudo-SARS-CoV-2 entered into the host cell and released viral core into the cytoplasm，which clearly indicates that the host entry mainly occurred through endocytosis. The infection efficiency was found to be correlated with the expression of the known receptor of SARS-CoV-2, angiotensin-converting 2 (ACE2) on the host cell surface. We believe that the dual-color fluorescence labeled pseudovirus system created in this study can be a useful tool in SARS-CoV-2/COVID-19 for many purposes.
Characteristics and Follow-Up of Organizing Pneumonia Associated with Hematologic Malignancies
Authors: Zeng Huihui , Shen Xiaoqing , He Xue , Cai Shan , Chen Ping , Chen Yan , Luo Hong 
Published: December 2020

Abstract
Background: Organizing pneumonia (OP) is a secondary process in many diseases. Due to low incidence and indistinct symptoms, there is limited information about OP associated with hematologic malignancies. To discuss the characteristics and prognosis of OP associated with hematologic malignancies, we conducted this study.Methods: We observed and analyzed pathologically confirmed OP cases associated with hematologic malignancies in hospital records database, and excluded OP cases with other related reasons, including chemotherapy, radiotherapy, targeted therapy, transplantation and infection. Result: There were 5 patients with OP underlying only hematologic malignancies, including one case of myelodysplastic syndrome, one case of acute myelogenous leukemia, one case of multiple myeloma case, one case of aplastic anemia, and one T cell lymphoma. Radiological findings did not show a distinct pattern, and two cases mimicked pulmonary aspergillosis. The diagnosis of OP was confirmed by minimally invasive biopsy. Although all patients developed into severe cases, steroids produced favorable outcomes. Conclusion: This study supports that hematologic malignancies might be a cause of OP and that minimally biopsy may be an effective and safe method to confirm the diagnosis. Although OP associated with hematologic malignancies might more frequently develop into severe cases, the OP lesions were steroid-responsive during follow-up.
Urine miRNA Signature as a Potential Non-invasive Diagnostic and Prognostic Biomarker in Cervical Cancer
Authors: Aftab Mehreen , Poojari Satish , Seshan Vaishnavi , Kumar Sachin , Agarwal Pallavi , Tandon Simran , Zutshi Vijay , Das Bhudev 
Published: December 2020

Abstract
MicroRNAs as cancer biomarkers in serum, plasma and other body fluids are often used but analysis of miRNA in urine is limited. We investigated the expression of selected miRNAs in the paired urine, serum, cervical scrape and tumor tissue specimens from the women with cervical precancer and cancer with a view to identify if urine miRNAs could be used as reliable non-invasive biomarkers for an early diagnosis and prognosis of cervical cancer. Expression of three oncomiRs (miR-21, miR-199a, and miR-155-5p) and three tumor suppressors (miR-34a, miR-145, and miR-218) in cervical pre-cancer, cancer and normal controls including cervical cancer cell lines were analyzed using qRT-PCR. The expression of miRNAs was correlated with various clinicopathological parameters, including HPV infection and survival outcome. We observed a significant overexpression of the oncomiRs and the downregulation of tumor suppressor miRNAs. A combination of miR-145-5p, miR-218-5p, and miR-34a-5p in urine yielded 100% sensitivity and 92.8% specificity in distinguishing precancer and cancer patients from healthy controls. The expression of miR-34a-5p and miR-218-5p were found to be independent prognostic factors for overall survival of cervical cancer patients. We conclude that the evaluation of specific miRNA expression in non-invasive urine samples may serve as reliable biomarker for early detection and prognosis of cervical cancer.
Preoperative High-Protein Diet Can Improve The Serum Albumin Levels of Patients Undergoing Total Knee Arthroplasty
Authors: Xu Hong , Liu Li , Xie Jinwei , Wang Duan , Huang Zeyu , Zhou Zongke 
Published: December 2020

Abstract
Background: Preoperative hypoproteinemia are risk factors for complications in patients undergoing total knee arthroplasty (TKA). However, the relationship between preoperative albumin levels and postoperative use of albumin is unclear, as are the effects of a high-protein diet on preoperative serum albumin levels for these patients. Methods: We retrospectively enrolled 660 patients who underwent primary TKA from January to December 2019, of whom 97 received postoperative albumin and 563 did not. Logistic and restrictive cubic spline regression analyses were used to explore the relationship between preoperative serum albumin levels and postoperative albumin use. Additionally, 88 patients undergoing primary TKA were educated to follow a high-protein diet during the preoperative waiting period from January to July 2020. From these 88 patients, data from laboratory tests on the day of the outpatient visit and admission were collected and compared to evaluate the effect of high-protein diet on preoperative serum albumin levels. Results: Higher preoperative serum albumin levels were negatively associated with risk of postoperative albumin use (relative risk 0.725, 95% confidence interval 0.666-0.789), and the risk of needing postoperative albumin decreased with increasing preoperative albumin level with a negative dose-response relationship (P overall < 0.001; P nonlinear = 0.186). After an average of 39.05±22.78 days on a high-protein diet, the albumin levels on admission (46.04±2.49 g/L) were significantly higher than on outpatient (42.79±4.09) g/L), while the biomarkers of liver and kidney function and lipid metabolism did not differ significantly between the two time points. Conclusions: Preoperative albumin levels were highly associated with postoperative albumin use, showing an obvious dose-response relationship. Preoperative high-protein diet could improve the albumin levels in patients undergoing TKA. Trial registration: The study was registered in the Chinese Clinical Trial Registry (registration no. ChiCTR2000034978) on July 26, 2020.
Cannabinoids accumulation in hemp (Cannabis sativa L) plants under LED light spectra and their discrete role as a stress marker
Authors: Islam Md. Jahirul , Azad Md Obyedul Kalam , Ryu Byung Ryeol , Rahman Md Hafizur , Lim Jung Dae , Cheong Eun Ju , Lim Young-Seok 
Published: December 2020

Abstract

Hemp adaptability through physiological and biochemical changes was studied under 10 LED light spectra and natural light in a controlled aeroponic system. Light treatments were imposed on 25 days aged seedlings for 16 hours daily (300 µmol m-2s-1) for 20 days. Plant accumulated highest Cannabidiol (CBD) in R7:B2:G1 light treatment, with relatively higher photosynthetic rate and lower reactive oxygen species, total phenol content, total flavonoid content, DPPH radical scavenging capacity, and antioxidant enzymatic activities. Tetrahydrocannabinol (THC) also accumulated higher in white, R8:B2, and R7:B2:G1 light with less evidence of stress modulated substances. These results indicated that CBD and THC have no or little relation with light-mediated abiotic stress in hemp plants. On the contrary, Tetrahydrocannabinolic acid (THCA) was accumulated higher in R6:B2:G1:FR1 and R5:B2:W2:FR1 light treatment along with lower photosynthetic rate and higher reactive oxygen species, total phenol content, total flavonoid content, DPPH radical scavenging capacity, and antioxidant enzymatic activities. However, Cannabidiolic acid (CBDA) was accumulated higher in R6:B2:G1:FR1 light treatment with higher stress modulated substances and lower physiological traits. CBDA was also accumulated higher in R8:B2 and R7:B2:G1 light treatments with less evidence of stress modulated substances. Besides, Greenlight influenced in CBD and CBDA synthesis where FR and UV-A (along with green) play a positive and negative role in this process, respectively. These results indicate that the role of THCA as a stress marker is more decisive in hemp plant than other cannabinoids under attributed light-mediated stress.
Development of experimental ground truth and quantification of intracranial aneurysm pulsation in a patient
Authors: Vanrossomme Axel , Chodzyński Kamil , Eker Omer , Boudjeltia Karim Zouaoui 
Published: December 2020

Abstract
Aneurysm wall motion has been reported to be associated with rupture. However, its quantification with medical imaging is challenging and should be based on experimental ground-truth to avoid misinterpretation of results. In this work a time-resolved CT angiography (4D-CTA) acquisition protocol is proposed to detect the pulsation of intracranial aneurysms with a low radiation dose. To acquire ground-truth data, the accuracy of pulsation detection and quantification in a silicone phantom was assessed by applying pressure sinusoidal waves of increasing amplitudes. These experiments were carried out using a test bench that could reproduce pulsatile waveforms similar to those inside the internal carotid arteries of human subjects. 4D-CTA acquisition parameters (mAs, kVp) were then selected to achieve reliable pulsation detection and quantification with the lowest radiation dose achievable. The resulting acquisition protocol was then used to image an anterior communicating artery aneurysm in a human subject. Data reveals that in a simplified in vitro setting 4D-CTA allows for an effective and reproducible method to detect and quantify aneurysm pulsation with an inferior limit as low as 3 mm³ and a background noise of 0.5 to 1 mm³. Aneurysm pulsation can be detected in vivo with a radiation dose approximating 1 mSv.
Automatic Image Classification Using Neural Networks Increases Accuracy for Allergenic Pollen Monitoring
Authors: Polling Marcel , Li Chen , Cao Lu , Verbeek Fons , Weger Letty de , Belmonte Jordina , Linares Concepción De , Willemse Joost , Boer Hugo de , Gravendeel Barbara 
Published: December 2020

Abstract
Monitoring of airborne pollen concentrations provides an important source of information for the globally increasing number of hay fever patients. Airborne pollen are traditionally counted under the microscope, but with the latest developments in image recognition methods, automating this process has become feasible. A challenge that persists, however, is that many pollen grains cannot be distinguished beyond the genus or family level using a microscope. Here, we assess the use of a Convolutional Neural Network (CNN) to increase taxonomic accuracy for airborne pollen. As a case study we use the nettle family (Urticaceae), which contains two main genera (Urtica and Parietaria) common in European landscapes which pollen cannot be separated by trained specialists. While pollen from Urtica species have very low allergenic relevance, those from several species of Parietaria are severely allergenic. We collect pollen from both fresh as well as from herbarium specimens and use these to train the CNN model VGG16. The model shows that Urticaceae pollen can be distinguished with 98.3% accuracy. We then apply our model on Urticaceae pollen collected from aerobiological samples and show that the genera can be confidently distinguished, despite the more challenging input images that are often overlain by debris. Our method can also be applied to other pollen families in the future and will thus help to make allergenic pollen monitoring more specific.
Gestational Diabetes and Intraoperative Tubal Sterilization are Risk Factors for Pain After Cesarean Delivery: A Prospective Observational Study.
Authors: Nivatpumin Patchareya , Pangthipampai Pawinee , Dej-Arkom Sukanya , Aroonpruksakul Somkiat , Lertbunnaphong Tripop , Ngam-ek-eu Tanyanun 
Published: December 2020

Abstract
Background: Postcesarean delivery pain leads to several adverse maternal outcomes. The primary objective of this study was to determine the incidence of moderate-to-severe pain after the use of spinal morphine for cesarean delivery. The secondary aim was to identify the factors influencing the moderate-to-severe pain.Methods: This prospective observational study was conducted at a single university hospital. The inclusion criteria were a patient age of ≥ 18 years, and undergoing elective cesarean delivery under spinal anesthesia with intrathecal morphine (200 mcg). Moderate-to-severe pain was defined as a numerical-rating-scale score of more than 3 within 24 hours postoperatively. Patients’ demographic characteristics, preoperative obstetric data, and intraoperative and postoperative data were collected and analyzed.Results: In all, 660 patients were enrolled. As 16 were subsequently removed because they met the study withdrawal criteria, data relating to 644 patients were analyzed. The incidence of moderate-to-severe pain during the first postoperative day was 451/644 patients (70.03%; 95% confidence interval [CI], 66.38%–73.44%). The median pain score (interquartile range [IQR]) was 5 (3–6), with 176/644 (27.33%) of patients requiring a rescue analgesic. A multivariate analysis revealed that two factors were associated with moderate-to-severe pain on the first postoperative day: gestational diabetes (adjusted OR [AOR], 1.849; 95% CI, 1.068–3.203; p-value = 0.028), and intraoperative tubal sterilization (AOR, 1.533; 95% CI, 1.060–2.218; p = 0.023). A significantly higher number of patients experienced moderate-to-severe pain on postoperative Day 1 (451/644 [70.03%]) than Day 2 (348/644 [54.19%]; p < 0.001). The median pain score (IQR) on postoperative Day 2 was 4 (3–5), which was less than that for Day 1 (p < 0.001).Conclusions: A high incidence of moderate-to-severe postoperative pain was found after a single dose of spinal morphine for cesarean delivery. Gestational diabetes and intraoperative tubal sterilization were the independent factors correlated with the pain.Trial registration: Clinicaltrial.gov registration number NCT03205813
Prevalence of Non-Communicable Diseases and Associated Factors in South Africa: Evidence from National Income Dynamics Survey, 2008-2017.
Authors: Bolarinwa Obasanjo Afolabi , Olagunju Olalekan Seun , Budu Eugene , Seidu Abdul-Aziz , Odetokun Ismail A , Al-Mustapha Ahmad I , Shezi Simangele Azande , Ahinkorah Bright Opoku 
Published: December 2020

Abstract
IntroductionThe unprecedented global increase in non-communicable diseases (NCDs) death incidences resulted in a joint initiative by the United Nations (UN) and the World Health Organization (WHO) to reduce NCD-related mortality by 25% by the year 2025. In this study, we ascertained the prevalence of NCDs in South Africa and its associated factors. MethodWe used 5-panel waves secondary datasets conducted by national income dynamic survey (NIDS) from 2008 to 2017 among 64,735 South Africans. We calculated the prevalence of all selected NCDs separately and together for each year at the descriptive level. This was followed by the distribution of selected NCDs across the socio-demographic and behavioural characteristics of the respondents. Finally, we used binary logistic regression to assess NCDs' likelihood by the respondents’ socio-demographic and behavioural characteristics. The results were presented as crude odds ratios (cOR) and adjusted odds ratios (aOR) with their corresponding 95% confidence intervals, signifying precision. Statistical significance was set at p-value < 0.05.ResultsWe found that, the prevalence of NCDs in South Africa was highest in the year 2012 (23.8%) and lowest in the year 2015 (15.2%). Over the 10-year period, the NCDs with highest and lowest prevalence were high blood pressure and cancer, respectively. Females [cOR = 1.88, 95% CI=1.79-1.96], smokers [cOR=2.01, 95% CI=1.85-2.19] and those very satisfied with life [cOR=1.10, 95% CI=1.04-1.17] were more likely to have atleast one NCDs. This persisted after adjusting for significant covariates: [aOR = 1.84, 95% CI=1.74-1.94], [aOR=1.49, 95% CI=1.35-1.65] and [aOR = 1.01, 95% CI=0.95-1.09] respectively.ConclusionSouth Africa’s department of health and other health agencies need to strengthen existing policies and develop new interventional frameworks that will deliberately consider various significant factors contributing to the high prevalence of NCDs identified in this study. This will reduce the NCDs prevalence and reduce the morbidity and mortality levels attributable to NCDs in the country.