bluuebunny/crossref_metadata_2025_split huggingface dataset:
GRIEF RESOLUTION: Facilitating Self-Transcendence in the Bereaved
Authors: Joffrion Louise P , Douglas Dianna 
Published: November 2019

The clinical nurse specialist (CNS) can help individuals to resolve grief that stems from personal loss and death, and encourage activities that will assist highly motivated individuals to achieve self-transcendence. The process of selftranscendence can be accomplished by the bereaved individual's participation in support groups facilitated by the clinical nurse specialist.
Societal responses to death and rituals during bereavement have been recorded throughout history. As health care became more technologically advanced, societal attitudes toward death and loss have changed. During this century, various authors have described individual responses to death and characteristic behaviors during bereavement (Freud, 1917/1957; Kübler-Ross. 1969; Lindemann. 1944) (Table I). The works of these authors also describe integration of loss and some steps of grief resolution; beyond the stage of grief resolution is self-transcendence. Selftranscendence is a state in which some individuals are able to overcome grief, integrate loss, and find meaning through lossfFrankl, 1984).
Identification‐ and singularity‐robust inference for moment condition models
Authors: Andrews Donald W. K. , Guggenberger Patrik 
Published: November 2019

This paper introduces a new identification‐ and singularity‐robust conditional quasi‐likelihood ratio (SR‐CQLR) test and a new identification‐ and singularity‐robust Anderson and Rubin (1949) (SR‐AR) test for linear and nonlinear moment condition models. Both tests are very fast to compute. The paper shows that the tests have correct asymptotic size and are asymptotically similar (in a uniform sense) under very weak conditions. For example, in i.i.d. scenarios, all that is required is that the moment functions and their derivatives have 2 +
γ bounded moments for some
γ > 0. No conditions are placed on the expected Jacobian of the moment functions, on the eigenvalues of the variance matrix of the moment functions, or on the eigenvalues of the expected outer product of the (vectorized) orthogonalized sample Jacobian of the moment functions.

The SR‐CQLR test is shown to be asymptotically efficient in a GMM sense under strong and semi‐strong identification (for all
k ≥
p, where
k and
p are the numbers of moment conditions and parameters, respectively). The SR‐CQLR test reduces asymptotically to Moreira's CLR test when
p = 1 in the homoskedastic linear IV model. The same is true for
p ≥ 2 in most, but not all, identification scenarios.

We also introduce versions of the SR‐CQLR and SR‐AR tests for subvector hypotheses and show that they have correct asymptotic size under the assumption that the parameters not under test are strongly identified. The subvector SR‐CQLR test is shown to be asymptotically efficient in a GMM sense under strong and semi‐strong identification.
Is the recovery of stratospheric O3 speeding up in the Southern Hemisphere? An evaluation from the first IASI decadal record (2008–2017)
Authors: Wespes Catherine , Hurtmans Daniel , Chabrillat Simon , Ronsmans Gaétane , Clerbaux Cathy , Coheur Pierre-François 
Published: November 2019

Abstract. In this paper, we present the global fingerprint of recent changes in
middle–upper stratosphere (MUSt; <25 hPa) ozone (O3) in
comparison with lower stratosphere (LSt; 150–25 hPa) O3 derived
from the first 10 years of the IASI/Metop-A satellite measurements (January 2008–December 2017). The IASI instrument provides vertically resolved
O3 profiles with very high spatial and temporal (twice daily)
samplings, allowing O3 changes to be monitored in these two regions of the
stratosphere. By applying multivariate regression models with adapted
geophysical proxies on daily mean O3 time series, we discriminate
anthropogenic trends from various modes of natural variability, such as the
El Niño–Southern Oscillation (ENSO). The representativeness of the
O3 response to its natural drivers is first examined. One important
finding relies on a pronounced contrast between a positive LSt O3
response to ENSO in the extratropics and a negative one in the tropics,
with a delay of 3 months, which supports a stratospheric pathway for the
ENSO influence on lower stratospheric and tropospheric O3. In terms of
trends, we find an unequivocal O3 recovery from the available period of
measurements in winter–spring at middle to high latitudes for the two
stratospheric layers sounded by IASI (>∼35∘ N–S in the MUSt and >∼45∘ S in the LSt) as well as in the total columns at southern latitudes
(>∼45∘ S) where the increase reaches
its maximum. These results confirm the effectiveness of the Montreal
Protocol and its amendments and represent the first detection of a
significant recovery of O3 concurrently in the lower, in the middle–upper
stratosphere and in the total column from one single satellite dataset. A
significant decline in O3 at northern mid-latitudes in the LSt is also
detected, especially in winter–spring of the Northern Hemisphere. Given
counteracting trends in the LSt and MUSt at these latitudes, the decline is not
categorical in total O3. When freezing the regression coefficients
determined for each natural driver over the whole IASI period but adjusting
a trend, we calculate a significant speeding up in the O3 response to
the decline of O3-depleting substances (ODSs) in the total column, in
the LSt and, to a lesser extent, in the MUSt, at high southern latitudes
over the year. Results also show a small significant acceleration of the
O3 decline at northern mid-latitudes in the LSt and in the total column
over the last few years. That, specifically, needs urgent investigation to
identify its exact origin and apprehend its impact on climate change.
Additional years of IASI measurements would, however, be required to confirm
the O3 change rates observed in the stratospheric layers over the last few
years.
Criterios prácticos de restauración arquitectónica a mediados del siglo XIX: la restauración de la iglesia románica de San Juan Ante Portam Latinam en Arroyo de la Encomienda (Valladolid)
Authors: Domínguez Burrieza Francisco Javier 
Published: November 2019

Resumen: La restauración de la iglesia románica de San Juan Ante Portam Latinam, en Arroyo de la Encomienda (Valladolid), en 1876, refleja algunas de las ideas violletianas dominantes en la práctica restauradora española de la época, así como la aplicación de la Real Orden de 14 de septiembre de 1850. Se trata del trabajo más personal, en este campo, del reputado arquitecto Jerónimo Ortiz de Urbina Díaz de Junguitu. Perteneciente a las primeras promociones de la Escuela Especial de Arquitectura de Madrid, condiscípulo de Demetrio de los Ríos y Juan de Madrazo y amigo de Adolfo Fernández de Casanova, todos ellos arquitectos restauradores influidos por Viollet-le-Duc. A la vez que incluimos numerosa documentación inédita (expedientes de obras y libros de actas), resaltamos el valor de la fotografía en este tipo de trabajos, recuperando cuatro de ellas que se realizaron en el año 1867. Abstrac: The restoration of the Romanesque church of San Juan Ante Portam Latinam, in Arroyo de la Encomienda (Valladolid), in 1876, reflects some of the dominant violletian ideas in Spanish restoration practice at the time, as well as the application of the Royal Order of 14 September 1850. This is the most personal work, in this field, of the renowned architect Jerónimo Ortiz de Urbina Díaz de Junguitu. He belonged to the first graduating classes of the Special School of Architecture of Madrid, fellow student of Demetrio de los Ríos and Juan de Madrazo and friend of Adolfo Fernández de Casanova, all of them restoring architects influenced by Viollet - le - Duc. At the same time that we include numerous unpublished documentation (files of works and books of minutes), we highlight the value of photography in this type of work, recovering four of them that were carried out in 1867.
Sequencing and analyses on chloroplast genomes of Tetrataenium candicans and two allies give new insights on structural variants, DNA barcoding and phylogeny in Apiaceae subfamily Apioideae
Authors: Kang Lu , Xie Dengfeng , Xiao Qunying , Peng Chang , Yu Yan , He Xingjin 
Published: November 2019

Background
Tetrataenium candicans is a traditional Chinese folk herbal medicine used in the treatment of asthma and rheumatic arthritis. Alongside several Tordyliinae species with fleshy roots, it is also regarded as a substitute for a Chinese material medicine called ‘Danggui’. However, a lack of sufficient sampling and genomic information has impeded species identification and the protection of wild resources.

Methods
The complete chloroplast genomes of T. candicans from two populations, Tetrataenium yunnanense and Semenovia transilliensis, were assembled from two pipelines using data generated from next generation sequencing (NGS). Pseudogenes, inverted repeats (IRs) and hyper-variable regions were located by Geneious 11.1.5. Repeat motifs were searched using MISA and REPuter. DNA polymorphism and segment screening were processed by DNAsp5, and PCR product was sequenced with Sanger’s sequencing method. Phylogeny was inferred by MEGA 7.0 and PhyML 3.0.

Results
The complete chloroplast genomes of T. candicans from two populations, T. yunnanense and S. transilliensis, were 142,261 bp, 141,985 bp, 142,714 bp and 142,145 bp in length, respectively, indicating conservative genome structures and gene categories. We observed duplications of trnH and psbA caused by exceptional contractions and expansions of the IR regions when comparing the four chloroplast genomes with previously published data. Analyses on DNA polymorphism located 29 candidate cp DNA barcodes for the authentication of ‘Danggui’ counterfeits. Meanwhile, 34 hyper-variable markers were also located by the five Tordyliinae chloroplast genomes, and 11 of them were screened for population genetics of T. candicans based on plastome information from two individuals. The screening results indicated that populations of T.candicans may have expanded. Phylogeny inference on Apiaceae species by CDS sequences showed most lineages were well clustered, but the five Tordyliinae species failed to recover as a monophyletic group, and the phylogenetic relationship between tribe Coriandreae, tribe Selineae, subtribe Tordyliinae and Sinodielsia clade remains unclear.

Discussion
The four chloroplast genomes offer valuable information for further research on species identification, cp genome structure, population demography and phylogeny in Apiaceae subfamily Apioideae.
Association between anthropometric indices of obesity and risk of cardiovascular disease in Japanese men
Authors: Xiang Mi , Hu Huanhuan , Imai Teppei , Nishihara Akiko , Sasaki Naoko , Ogasawara Takayuki , Hori Ai , Nakagawa Tohru , Yamamoto Shuichiro , Honda Toru , Okazaki Hiroko , Uehara Akihiko , Yamamoto Makoto , Miyamoto Toshiaki , Kochi Takeshi , Eguchi Masafumi , Murakami Taizo , Shimizu Makiko , Tomita Kentaro , Nagahama Satsue , Nanri Akiko , Konishi Maki , Akter Shamima , Kuwahara Keisuke , Kashino Ikuko , Yamaguchi Miwa , Kabe Isamu , Mizoue Tetsuya , Kunugita Naoki , Dohi Seitaro ,   Japan Epidemiology Collaboration on Occupational Health Study Group, Inoue Y , Fukunaga A , Islam Z , Kurotani K , Watanabe Y , Ogasawara T , Hasegawa M , Shirozu M , Shimizu C , Gonmori N , Ogasawara A , Kato N , Tomizawa A , Sone T , Fukasawa K , Nishiura C , Kinugawa C , Kuroda R , Yamamoto K , Ohtsu M , Sakamoto N , Osaki Y , Totsuzaki T , Endo M , Itoh T , Kawashima M , Masuda M , Kitahara K , Yokoya T , Fukai K , Odagami K , Kobayashi Y 
Published: November 2019

Abstract

Objectives
We aimed to compare the association of body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) with risk of cardiovascular disease (CVD) among middle-aged working Japanese men.

Methods
A nested case-control study was performed among middle-aged male employees who underwent periodic health checkup. A total of 241 CVD cases were identified and matched individually on age, gender, and worksite with 1205 controls. Data on BMI, WC, WHtR, smoking, hypertension, diabetes, and dyslipidemia collected at 4 years before the event/index date were retrieved. Associations between BMI, WC, WHtR, and CVD risk were assessed by using conditional logistic regression models.

Results
The strength of the association of BMI, WC, and WHtR with CVD risk was similar. The smoking-adjusted odds ratio (95% confidence interval) for CVD was 1.60 (1.38-1.85), 1.53 (1.33-1.78), and 1.56 (1.35-1.81) for a 1 SD unit increase in BMI, WC, and WHtR respectively. After further adjustment for hypertension, diabetes, and dyslipidemia, these associations were attenuated but remained statistically significant.

Conclusions
Measures of general (BMI) and abdominal (WC and WHtR) obesity were similarly associated with CVD in middle-aged Japanese men.
Antenatal Screening for Down Syndrome: The Impact ofNIPT
Authors: Bryant Louise D 
Published: November 2019

AbstractNoninvasive prenatal testing (NIPT) is one of the most significant recent technological developments in prenatal testing for Down syndrome. It offers pregnant women an early, safe, highly accurate screening test for Down syndrome. To support informed choice, clinicians must be clear about the limitations of NIPT and that it may not always be the best test for all women in all circumstances. The implementation of NIPT has sparked a debate around the routinisation of a near‐diagnostic test and its potential negative impact on people with Down syndrome and their families. Information that gives a balanced and accurate picture of lives of people with Down syndrome and their families is essential to support decision‐making, as are well‐informed health professionals. The degree to which NIPT will reduce the population of people with Down syndrome and impact on their quality of life is not yet known but must be monitored.Key ConceptsNoninvasive prenatal testing (NIPT) for Down syndrome (trisomy 21) using cell‐free DNA from the placenta in maternal blood has rapidly become available in many parts of the world.NIPT can be carried out reliably from around 9 weeks gestation, carries no risk of miscarriage, has a higher detection rate and lower false positive and negatives rates than existing screening tests but is not yet diagnostic.NIPT can be used as a first‐stage screening test to all pregnant women or as a second‐stage test for women identified as already having a higher chance of an affected pregnancy via other screening tests or maternal age. NIPT is more accurate for women already identified as having a higher chance of an affected pregnancy.Research with pregnant women shows that NIPT is generally viewed positively as an advancement in prenatal care, particularly if offered as a first‐stage screening test.The limitations of the new screening test are less well understood than the benefits, which may impact on the ability of women to make informed choices. Some research suggests that women and health professionals may not consider the decision‐making process for NIPT as important as for tests associated with miscarriage.There are fears, highlighted by campaign groups that the widespread introduction of NIPT will lead to increased terminations and the significant reduction in the number of people with Down syndrome in society.Early evidence suggests that NIPT may not have as great an impact as anticipated on termination rates for Down syndrome as some anticipated in the United Kingdom and the United States, but in some other countries numbers of terminations for Down syndrome have significantly increased. It is as yet too early to ascertain what the impact of NIPT will be in this respect.Efforts to improve informed choice for prenatal screening via information and training for health professionals may be undermined by the lack of high‐quality services for children and adults with Down syndrome, as some women perceive that continuing an affected pregnancy is not a viable option.
Cell Wall Responses to Biotrophic Fungal Pathogen Invasion
Authors: Chowdhury Jamil , Coad Bryan R. , Little Alan 
Published: November 2019

AbstractTo a plant the surrounding environment is filled with microbial organisms looking to take advantage of the bountiful resources held within. In order for a pathogen to access the internal nutrients it must gain entry through the plant cell outer layers that consist of the cuticular wax and the plant cell wall. This barrier is a complex structure composed of diverse waxes, lipids, polysaccharides, proteins, lignin, and antimicrobial compounds and plays many crucial roles during plant defence, growth, and development. We now have more evidence than ever about the dynamic nature of the cell wall providing various interaction‐dependent passive and active defence responses, hence justifying a necessity of evolving such a complex structure. Here we summarise the current understanding of this multi‐layered defence system, using the biotrophic interaction between barley and the causal agent of powdery mildew,Blumeria graminisf. sp.hordei(Bgh).
High‐frequency oscillations mirror severity of human temporal lobe seizures
Authors: Schönberger Jan , Birk Nadja , Lachner‐Piza Daniel , Dümpelmann Matthias , Schulze‐Bonhage Andreas , Jacobs Julia 
Published: November 2019

AbstractObjectiveMany patients with epilepsy have both focal and bilateral tonic‐clonic seizures (BTCSs), but it is largely unclear why ictal activity spreads only sometimes. Previous work indicates that interictal high‐frequency oscillations (HFOs), traditionally subdivided into ripples (80–250 Hz) and fast ripples (250–500 Hz), are a promising biomarker of epileptogenicity. We aimed to investigate whether HFOs correlate with the emergence of seizure activity and whether they differ between focal seizures (FSs) with impaired awareness and BTCSs.MethodsWe retrospectively analyzed 15 FSs and 13 BTCSs from seven patients with mesial temporal lobe epilepsy, each of them with at least one BTCS and at least one FS. Representative intervals of intracranial electroencephalography from the seizure onset zone (SOZ) and remote non‐SOZ areas were selected to compare pre‐ictal, complex focal, tonic‐clonic, and postictal periods. Ripples and fast ripples were visually identified and their density, that is, percentage of time occupied by the respective events, computed.ResultsRipple and fast ripple densities increased inside the SOZ after seizure onset (P < 0.01) and in remote areas after progression to BTCSs (P < 0.01). Postictal SOZ ripple density dropped below pre‐ictal levels (P < 0.001). Prior to onset of bilateral tonic‐clonic movements, ripple density inside the SOZ is higher in BTCSs than in FSs (P < 0.05).InterpretationRipples and fast ripples correlate with onset and spread of ictal activity. Abundant ripples inside the SOZ may reflect the activation of specific neuronal networks related to imminent spread of seizure activity.
Skeletal muscle mass in female athletes: The average and the extremes
Authors: Abe Takashi , Wong Vickie , Dankel Scott J. , Bell Zachary W. , Spitz Robert W. , Viana Ricardo B. , Loenneke Jeremy P. 
Published: November 2019

AbstractObjectivesTo examine the absolute and relative skeletal muscle mass (SM) in female athletes and to discuss the potential upper limit of whole‐body muscle mass between large sized female and male athletes.MethodsForty‐five female athletes and forty‐five recreationally active females (control) had muscle thickness measured by ultrasound at nine sites on the anterior and posterior aspects of the body. SM was estimated from an ultrasound‐derived prediction equation. Body fat percentage and fat‐free mass (FFM) were calculated from ultrasound measured subcutaneous fat thickness. To eliminate fat‐free component of adipose tissue (FFAT), we calculated FFM minus FFAT (FFM‐FFAT).ResultsFFM, FFM‐FFAT, and muscle mass were markedly higher in athletes. Fat Mass was similar (Athlete: 14.9 kg vs Control: 12.9 kg [median value]). The large‐sized female athletes had approximately 9 to 11 kg FFAT which corresponds to about 10% to 15% of FFM. Seven of the female athletes had more than 60 kg of FFM‐FFAT, the largest of whom had 77.0 kg of FFM‐FFAT. SM increased in a parabolic fashion reaching a value of 35 kg SM beyond 100 kg body mass. Only one of the athletes had a SM index of more than 13 kg/m2.ConclusionsFemale athletes had much greater muscle mass than controls. In large‐sized female athletes, the influence of FFAT needs to be considered when interpreting their FFM. In addition, the largest SM index in female athletes was 13.2 kg/m2, which was approximately 77% of that observed with the largest male athlete ever recorded. This difference appears similar to that observed in nonathletes.
Revision surgery rates in chronic rhinosinusitis with nasal polyps: meta‐analysis of risk factors
Authors: Loftus Catherine A. , Soler Zachary M. , Koochakzadeh Sina , Desiato Vincent M. , Yoo Frederick , Nguyen Shaun A. , Schlosser Rodney J. 
Published: November 2019

BackgroundWide variations in revision endoscopic sinus surgery (ESS) rates for chronic rhinosinusitis with nasal polyposis (CRSwNP) have been reported. It is important to understand expected revision rates and factors that impact the need for revision.MethodsA literature search was conducted on PubMed, Scopus, and the Cochrane Database of Systematic Reviews. Following PRISMA guidelines, a systematic review and meta‐analysis was performed on studies that reported revision surgery data for CRSwNP patients.ResultsForty‐five studies with 34,220 subjects were meta‐analyzed, with an overall revision rate of 18.6% (95% confidence interval, 14.1%‐23.6%). Studies with extractable follow‐up data reported a mean revision rate of 16.2% over a weighted mean follow‐up of 89.6 months. Factors associated with increased revision rates included allergic fungal rhinosinusitis (28.7%), aspirin‐exacerbated respiratory disease (27.2%), asthma (22.6%), prior polypectomy (26.0%), and publication prior to 2008 (22.7%) (p < 0.05 for all).ConclusionAlthough polyps can recur after ESS, reported long‐term ESS revision rates are approximately 14% to 24%. Identifying risk factors for revision surgery can help manage patient expectations and determine optimal personalized treatments.