bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rooting the animal tree of life
Authors: Li Yuanning , Shen Xing-Xing , Evans Benjamin , Dunn Casey W. , Rokas Antonis 
Published: October 2020

SummaryThere has been considerable debate about the placement of the root in the animal tree of life, which has emerged as one of the most challenging problems in animal phylogenetics. This debate has major implications for our understanding of the earliest events in animal evolution, including the origin of the nervous system. Some phylogenetic analyses support a root that places the first split in the phylogeny of living animals between sponges and all other animals (the Porifera-sister hypothesis), and others find support for a split between comb jellies and all other animals (Ctenophora-sister). These analyses differ in many respects, including in the genes considered, species considered, molecular evolution models, and software. Here we systematically explore the rooting of the animal tree of life under consistent conditions by synthesizing data and results from 15 previous phylogenomic studies and performing a comprehensive set of new standardized analyses. It has previously been suggested that site-heterogeneous models favor Porifera-sister, but we find that this is not the case. Rather, Porifera-sister is only obtained under a narrow set of conditions when the number of site-heterogeneous categories is unconstrained and range into the hundreds. Site-heterogenous models with a fixed number of dozens of categories support Ctenophora-sister, and cross-validation indicates that such models fit the data just as well as the unconstrained models. Our analyses shed light on an important source of variation between phylogenomic studies of the animal root. The datasets and analyses consolidated here will also be a useful test-platform for the development of phylogenomic methods for this and other difficult problems.
Glycinergic axonal inhibition subserves acute spatial sensitivity to sudden increases in sound intensity
Authors: Franken Tom P. , Bondy Brian J. , Haimes David B. , Golding Nace L. , Smith Philip H. , Joris Philip X. 
Published: October 2020

AbstractLocomotion generates adventitious sounds which enable detection and localization of predators and prey. Such sounds contain brisk changes or transients in amplitude. We investigated the hypothesis that ill-understood temporal specializations in binaural circuits subserve lateralization of such sound transients, based on different time of arrival at the ears (interaural time differences, ITDs). We find that Lateral Superior Olive (LSO) neurons show exquisite ITD-sensitivity, reflecting extreme precision and reliability of excitatory and inhibitory postsynaptic potentials, in contrast to Medial Superior Olive neurons, traditionally viewed as the ultimate ITD-detectors.In vivo, inhibition blocks LSO excitation over an extremely short window, which,in vitro, required synaptically-evoked inhibition. Light and electron microscopy revealed inhibitory synapses on the axon initial segment as the structural basis of this observation. These results reveal a neural vetoing mechanism with extreme temporal and spatial precision and establish the LSO as the primary nucleus for binaural processing of sound transients.
Medial septum neurokinin- and somatostatin-sensitive mechanisms mediate sensorimotor and nociceptive behaviours
Authors: Ng Si Yun , Lee Andy Thiam-Huat , Ariffin Mohammed Zacky , Woon Pei Jun , Chng Terence Sheng Hao , Khanna Sanjay 
Published: October 2020

AbstractThe forebrain medial septum (MS), implicated in affective-motivational behaviours, is enriched in substance P (SP) sensitive neurokinin-1 receptors (NK1R) and somatostatin (SST) receptors (SSTR) that are located almost exclusively on cholinergic and GABAergic neurons, respectively. However, the physiological function of these receptors is poorly understood. This study characterized the actions of intraseptal SP on electrophysiological indices of septo-hippocampal activation, then utilised NK1 receptor antagonist, L-733,060, and SST to investigate the physiological role of endogenous neurotransmission at NK1R, and SST-sensitive mechanisms, in novel open field and formalin test of inflammatory pain. The findings showed that neurotransmission at NK1R mediates formalin-induced electrophysiological responses in the septo-hippocampus in anaesthetized and behaving animals. Furthermore, parallel NK1R- and SST-sensitive mechanisms affect different aspects of animal behaviours in both tests, collectively modulating attention and habituation in open field and driving formalin-induced nociception. This brings out a newer peptidergic dimension of septal physiology in nociception.
Genomic Diversity in a Population of Spodoptera frugiperda Nucleopolyhedrovirus
Authors: Masson Tomás , Fabre María Laura , Pidre Matias Luis , Niz José María , Berretta Marcelo Facundo , Romanowski Víctor , Ferrelli María Leticia 
Published: October 2020

AbstractSpodoptera frugiperda multiple nucleopolyhedrovirus (SfMNPV) represents a strong candidate to develop environmental-friendly pesticides against the fall armyworm (Spodoptera frugiperda), a widespread pest that poses a severe threat to different crops around the world. However, little is known regarding the genomic diversity present inside SfMNPV isolates and how it shapes the interactions between virus and host. Here, the genomic diversity present inside an isolate of SfMNPV was explored using high-throughput sequencing for the first time. We identified 704 intrahost single nucleotide variants, from which 184 are nonsynonymous mutations distributed among 82 different coding sequences. We detected several structural variants affecting SfMNPV genome, including two previously reported deletions inside theegtregion. A comparative analysis between polymorphisms present in different SfMNPV isolates and our intraisolate diversity data suggests that coding regions with higher genetic diversity are associated with oral infectivity or unknown functions. In this context, through molecular evolution studies we provide evidence of diversifying selection acting onsf29, a putative collagenase which could contribute to the oral infectivity of SfMNPV. Overall, our results contribute to deepen our understanding of the coevolution between SfMNPV and the fall armyworm and will be useful to improve the applicability of this virus as a biological control agent.HighlightsWe characterized the genomic diversity within a population of SfMNPV.Coding regions with higher genetics diversity are associated with oral infectivity or unknown functions.Several structural variants contribute to the genomic diversity of SfMNPV.Sf29, a putative collagenase, shows signs of adaptive evolution.
Genetic landscape of recessive diseases in the Vietnamese population from large-scale clinical exome sequencing
Authors: Tran Ngoc Hieu , Thi Thanh-Huong Nguyen , Tang Hung-Sang , Hoang Le-Phuc , Le Nguyen Trung-Hieu , Tran Nhat-Thang , Trinh Thu-Huong Nhat , Nguyen Van Thong , Nguyen Bao-Han Huu , Nguyen Hieu Trong , Doan Loc Phuoc , Phan Ngoc-Minh , Nguyen Kim-Huong Thi , Nguyen Hong-Dang Luu , Quach Minh-Tam Thi , Nguyen Thanh-Phuong Thi , Tran Vu Uyen , Tran Dinh-Vinh , Nguyen Quynh-Tho Thi , Do Thanh-Thuy Thi , Lam Nien Vinh , Ngoc Phuong Cao Thi , Truong Dinh Kiet , Nguyen Hoai-Nghia , Phan Minh-Duy , Giang Hoa 
Published: October 2020

AbstractPurposeAccurate profiling of population-specific recessive diseases is essential for the design of cost-effective carrier screening programs. However, minority populations and ethnic groups, including Vietnamese, are still under-represented in existing genetic studies. Here we reported the first comprehensive study of recessive diseases in the Vietnamese population.MethodsClinical exome sequencing (CES) data of 4,503 disease-associated genes obtained from a cohort of 985 Vietnamese individuals was analyzed to identify pathogenic variants, associated diseases and their carrier frequencies in the population.ResultsEighty-five recessive diseases were identified in the Vietnamese population, among which seventeen diseases had carrier frequencies of at least 1% (1 in 100 individuals). Three diseases were especially prevalent in the Vietnamese population with carrier frequencies of 2-12 times higher than in other East Asia or the world populations, including Beta-thalassemia (1 in 25), citrin deficiency (1 in 33) and phenylketonuria (1 in 40). Seven novel pathogenic and three likely pathogenic variants associated with nine recessive diseases were also discovered.ConclusionsThe comprehensive profile of recessive diseases identified in this study shall enable the design of cost-effective carrier screening programs specific to the Vietnamese population. The newly discovered pathogenic variants may also exist in other populations at extremely low frequencies, thus representing a valuable resource for future research. Our study has demonstrated the advantage of population-specific genetic studies to advance the knowledge and practice of medical genetics.
Depletion of senescent cells improves functional recovery after spinal cord injury
Authors: Paramos-de-Carvalho Diogo , Martins Isaura , Cristóvão Ana Margarida , Dias Ana Filipa , Neves-Silva Dalila , Pereira Telmo , Chapela Diana , Farinho Ana , Jacinto António , Saúde Leonor 
Published: October 2020

SUMMARYPersistent senescent cells (SCs) are known to underlie ageing-related chronic disorders, but it is now recognized that SCs may be at the center of tissue remodeling events, namely during development or organ repair. Here we show that two distinct senescence profiles are induced in the context of a spinal cord injury between the regenerating zebrafish and the non-regenerating mouse. While induced-SCs in the zebrafish are progressively cleared out, they accumulate over time in mice. Depletion of SCs in spinal cord injured mice, with different senolytic drugs, improved locomotor, sensory and bladder functions. This functional recovery is associated with improved myelin sparing, reduced fibrotic scar, attenuated inflammation and increased axonal growth. Targeting SCs is a promising therapeutic strategy not only for spinal cord injuries but potentially for other organs that lack regenerative competence.
Organizational resources and survival of startups firms – a qualitative analysis in the Peruvian context
Authors: Alvarez Salazar Jubalt 
Published: October 2020

PurposeThe purpose of this paper is to use a combination of resource-based theory and dynamic capabilities theory to explore the phenomenon of startup survival in an emerging entrepreneurial ecosystem.Design/methodology/approachThe study has a phenomenological research design, with an exploratory scope and qualitative approach. It uses in-depth interviews to identify the perceptions of ecosystem agents about the phenomenon of survival.FindingsThis paper argues that startup survival should be studied as a construct that is reflected by four conditions: break-even point, accelerated growth, cash stock and continuous operation. Furthermore, it is formed by the interaction of five mainly interacting resources: human capital, social capital, entrepreneurial capital, organizational capital and the incubation process.Originality/valueThe study offers a holistic model of survival that could be applicable to incipient entrepreneurial ecosystems such as the Peruvian one. This model presents survival as a reflexive-formative construct and not as a dichotomic variable (enterprise operating/enterprise closed) as has been commonly considered in the literature.
Determinants of corporate effective tax rates: evidence from the euro area
Authors: Barbera Antonio , Merello Paloma , Molina Rafael 
Published: October 2020

PurposeThe purpose of this paper is to investigate the effect of the determinants of corporate effective tax rates (ETR) of listed companies in euro area.Design/methodology/approachWith a large and recent panel of 2,870 listed companies for the period 2005–2016, the authors use the generalized moments method (GMM) to estimate global models for three groups of countries and specific models for six selected countries: Germany, Spain, France, Italy, Belgium and Greece.FindingsThe results confirm that ETR have different determinants depending on the countries analyzed. There is a significantly positive relationship with leverage and negative with size and financial profitability. However, economic profitability shows a statistically positive effect in the new members, but negative effect on old ones. In the individual analysis, Germany and Spain maintain this negative association with return on assets (ROA), but Belgium and Greece show a positive effect. The effect of the economic cycle shows statistically relevant, negatively in Germany but positively in Belgium and Greece.Originality/valueThis paper makes a novel contribution to the current debate on the need for harmonization of corporate income tax in the European Union (EU). For the first time, the group of countries whose common currency is the euro is considered with a great level of detail. In addition, the impact derived from the enlargement of the euro area and the individual analysis of the main countries is included. The European authorities must take into account the specific differences found in the ETR determinants because it hinders to take measures that limit tax competition.
Organizational ambidexterity: antecedents, performance and environmental uncertainty
Authors: Kafetzopoulos Dimitrios 
Published: October 2020

PurposeThis paper is to examine whether organizational ambidexterity leads to success. Moreover, it attempts to understand how proactiveness and quality orientation might create and maintain ambidexterity. Environmental uncertainty as a moderator is also examined.Design/methodology/approachTo achieve these objectives an empirical survey was conducted among 449 firms in Greece. Initially, EFA and then CFA were applied. Finally, the structural relationships among the latent factors were determined through SEM.FindingsOrganizational ambidexterity leads to superior business performance, moreover, the two antecedents were positively related to organizational ambidexterity. Environmental uncertainty acts as a moderator between organizational ambidexterity– business performance and proactiveness–organizational ambidexterity.Research limitations/implicationsA research challenge is to understand how organizations develop ambidexterity competency in different organizational structure. Moreover, it will be important to expand the model by taking into consideration different factors of antecedents, for example, type of innovation or different strategic orientations.Practical implicationsThis study sends the message that companies focussing on specific antecedents can be led to higher ambidexterity capabilities, which in turn act as a catalyst for business improvement.Originality/valueThe proposed model provides plausible guidelines that advance organizational ambidexterity research in the companies.
New normal and library services in Indonesia: a case study of university libraries
Authors: Winata Arda Putri , Fadelina Raisa , Basuki Sulistyo 
Published: October 2020

Purpose
This paper aims to share the activities of library services in the new-normal era. The paper describes libraries’ circumstances since their reopening in early June 2020. Furthermore, it provides details on how libraries have adopted several most appropriate practices changing physical to online services.

Design/methodology/approach
This paper describes various university library services in Indonesia in the new-normal era by using literature and documentary reviews as the approaches. The data were primarily collected from webpages, blogs, social media, newsletters and specific journals organized by university libraries. The survey was carried out by involving 126 university librarians incorporated in the University Libraries Forum. It highlighted the current conditions of university libraries and the most appropriate practices of library services in the new-normal era.

Findings
The most appropriate practices of university library services in the new-normal era are provided. Libraries in Indonesia have experienced a service transformation implementing the COVID-19 health protocols. Likewise, almost all university library services became virtual. Accordingly, there were several challenges faced by librarians and users in carrying out virtual activities in the library.

Originality/value
This paper provides a great value for libraries in responding to COVID-19 and those starting to reopen. It reveals the most appropriate library service practices and challenges in the new-normal era, which are useful for current and future insight development.
Conceptualization and initial measurement of counseling ethics competency: the influence of spirituality and self-efficacy
Authors: Zakaria Noor Syamilah , Subarimaniam Neerushah , Wan Jaafar Wan Marzuki , Mohd Ayub Ahmad Fauzi , Saripan M. Iqbal 
Published: October 2020

Purpose
This paper aims to contribute to the existing conceptualizations of counseling ethics competency and to develop a counseling ethics competency scale. This paper also argues that spirituality and self-efficacy influence counseling ethics competency.

Design/methodology/approach
A series of studies were performed to develop hypotheses and a conceptual framework to determine the relationships among spirituality, self-efficacy and counseling ethics competency. To measure registered counselors’ counseling ethics competency, a document analysis of the Counselors Code of Ethics was conducted and pretested on the basis of a pilot test prior to the empirical development of the scale.

Findings
A conceptual framework was developed to operationalize the theory and to present the influence of spirituality and self-efficacy on counseling ethics competency. The counseling ethics competency scale was found reliable and valid to measure the registered counselors’ competency in the eight components of the Counselors Code of Ethics.

Practical implications
The scale and framework can be used as tools to identify competencies where registered counselors are lacking and to pinpoint skills on which counselors need to improve. This research also will provide insights for counselor educators to be innovative in teaching and learning ethics within the scope of counselor education training programs.

Originality/value
There is no specific scale available to measure counseling ethics competency among registered counselors in Malaysia. Thus, this research unveils the importance of measuring counseling ethics competency in molding effective and ethical Malaysian counselors, and subsequently pinpointing factors that can improve counseling ethics competency.

Recommendations
We recommend to assess the scale using EFA, followed by CFA to determine and confirm the factor structure of the scale items. In terms of the field, future scope may not just focus on the traits, characters and skills building but also place more emphasis on ethics comprehension toward best practices of ethics application and internalization on becoming self-sufficient counselors.
HerCulB: content-based information extraction and retrieval for cultural heritage of the Balkans
Authors: Tanasijević Ivana , Pavlović-Lažetić Gordana 
Published: October 2020

Purpose
The purpose of this paper is to provide a methodology for automatic annotation of a multimedia collection of intangible cultural heritage mostly in the form of interviews. Assigned annotations provide a way to search the collection.

Design/methodology/approach
Annotation is based on automatic extraction of metadata and is conducted by named entity and topic extraction from textual descriptions with a rule-based approach supported by vocabulary resources, a compiled domain-specific classification scheme and domain-oriented corpus analysis.

Findings
The proposed methodology for automatic annotation of a collection of intangible cultural heritage, applied on the cultural heritage of the Balkans, has very good results according to F measure, which is 0.87 for the named entity and 0.90 for topic annotation. The overall methodology enables encapsulating domain-specific and language-specific knowledge into collections of finite state transducers and allows further improvements.

Originality/value
Although cultural heritage has a significant role in the development of identity of a group or an individual, it is one of those specific domains that have not yet been fully explored in case of many languages. A methodology is proposed that can be used for incorporating natural language processing techniques into digital libraries of cultural heritage.
Differentiating service quality impact between the online and off-line context: an empirical investigation of a corporate travel agency
Authors: Fang Ling , Lu Zhen , Dong Linyin 
Published: October 2020

PurposeCorporate travel represents a significant source of revenue for the tourism industry. Therefore, the quality of service is essential for maintaining and expanding corporate cliental bases. Despite the importance, the extant literature has yet sufficiently examined corporate travel service quality (SQ) and its impact. To make up for the drawback, this study aims to differentiate the impact of SQ perceptions on customer satisfaction between the online and off-line contexts through an empirical investigation in one of the top five corporate travel agencies in North America.Design/methodology/approachThe well-established SERVQUAL measurement is applied in differentiating the impact of SQ dimensions between the online and off-line context. To empirically test the proposed corporate travel agency (CTA) SQ conceptual model, a set of survey data of “Welcome Back Survey” from HRG (a top five CTA in North America) was examined.FindingsThe study finds that for online services, assurance, responsiveness and empathy affect perceived SQ, whereas for off-line services, assurance, empathy and tangible are the three dimensions of perceived SQ.Research limitations/implicationsBy relying on the existing survey, the off-line context has one less dimension than the online context. Yet as an early effort in differentiating the differences in the impact of SQ between two service contexts, the study offers insightful findings.Practical implicationsThe findings will be helpful for business managers of CTAs to identify the factors that influence SQ in both online booking and off-line booking context. In particular, assurance and empathy are two dimensions that exert a significant impact on customer satisfaction.Originality/valueThis paper is the first to compare the differences of the SQ of online and off-line corporate travel.