bluuebunny/crossref_metadata_2025_split huggingface dataset:
Statistical power in COVID-19 case-control host genomic study design
Authors:   On behalf of the Genetic Epidemiology Committee of the Canadian COVID Genomics Network (CanCOGeN) HostSeq Project, Lin Yu-Chung , Brooks Jennifer D. , Bull Shelley B. , Gagnon France , Greenwood Celia M. T. , Hung Rayjean J. , Lawless Jerald , Paterson Andrew D. , Sun Lei , Strug Lisa J. 
Published: December 2020

AbstractThe identification of genetic variation that directly impacts infection susceptibility to SARS-CoV-2 and disease severity of COVID-19 is an important step towards risk stratification, personalized treatment plans, therapeutic, and vaccine development and deployment. Given the importance of study design in infectious disease genetic epidemiology, we use simulation and draw on current estimates of exposure, infectivity, and test accuracy of COVID-19 to demonstrate the feasibility of detecting host genetic factors associated with susceptibility and severity in published COVID-19 study designs. We demonstrate that limited phenotypic data and exposure/infection information in the early stages of the pandemic significantly impact the ability to detect most genetic variants with moderate effect sizes, especially when studying susceptibility to SARS-CoV-2 infection. Our insights can aid in the interpretation of genetic findings emerging in the literature and guide the design of future host genetic studies.
Swiss trade during the COVID-19 pandemic: an early appraisal
Authors: Büchel Konstantin , Legge Stefan , Pochon Vincent , Wegmüller Philipp 
Published: December 2020

AbstractThis study uses trade data from Switzerland’s Federal Customs Administration to examine the impact ofCovid-19 on international goods trade between January and July 2020. We show that Swiss trade during that period fell by 11% compared to 2019 and that the contraction following the “Federal Lockdown” in mid-March was considerably steeper than the Swiss trade collapse in the aftermath of the Lehman Brothers bankruptcy in September 2008. Examining cross-country variation inCovid-19 cases, the stringency of containment measures, and Swiss trade flows, we document that the pandemic adversely affected both the demand and supply side of foreign trade, while trade restrictions and exchange rate fluctuations played no major role behind the rapid decline of Swiss trade in the first half of 2020.
Salivary Immunoendocrine and Self-report Monitoring Profiles across an Elite-Level Professional Football Season
Authors: Springham Matthew , Williams Sean , Waldron Mark , Strudwick Anthony J. , Mclellan Chris , Newton Robert U. 
Published: December 2020

ABSTRACT

Purpose
This investigation examined the longitudinal changes and interrelationships of salivary and self-report monitoring measures across a professional football season.

Methods
Measures were collected biweekly from 18 senior professional male players across a 6-wk preseason and eight 5-wk in-season mesocycles and analyzed using a linear mixed-effects model.

Results
Analysis identified a small (P = 0.003) cross-season suppression of salivary immunoglobulin A, small reductions to salivary α-amylase (P = 0.047) and salivary cortisol (P = 0.007), and trivial changes to salivary testosterone (P > 0.05). The testosterone/cortisol ratio typically responded inversely to changes in player workload. Self-report measures of fatigue (P = 0.030), sleep quality (P = 0.003), and muscle soreness (P = 0.005) improved (ES = small) across the first half of the season. Fatigue and sleep measures were most consistently related to hormonal measures (R
2 = 0.43–0.45). For these relationships, increases in cortisol were associated with compromised self-report responses, whereas increases in testosterone/cortisol were associated with improved responses. Nonlinear relationships were identified for fatigue with immunoglobulin A (P = 0.017; ES = trivial) and testosterone (P = 0.012; ES = trivial), for sleep quality with testosterone (P < 0.001; ES = trivial), for muscle soreness with testosterone (P = 0.012; ES = trivial), and for the self-report inventory sum with testosterone (P = 0.027; ES = trivial). For these relationships, self-report responses were optimal at mean immunoglobulin A and testosterone levels, and very low levels (−2 SD) exerted the most compromising effects.

Conclusions
Players can experience a chronic cross-season suppression of mucosal immunity. Salivary immunoglobulin A, testosterone, cortisol, and testosterone/cortisol measures relate to self-report measures of fatigue, sleep quality, and muscle soreness. In-season reductions in testosterone, cortisol, and testosterone/cortisol or increases in cortisol among elite football players could be used to indicate the need for reduced workload, which might lead to improved well-being.
Sex Matters in the Association between Physical Activity and Fitness with Cognition
Authors: CASTELLS-SÁNCHEZ ALBA , ROIG-COLL FRANCESCA , LAMONJA-VICENTE NOEMÍ , TORÁN-MONSERRAT PERE , PERA GUILLEM , MONTERO PILAR , DACOSTA-AGUAYO ROSALIA , BERMUDO-GALLAGUET ADRIÀ , BHERER LOUIS , ERICKSON KIRK I. , MATARÓ MARIA 
Published: December 2020

ABSTRACT

Purpose
The benefits from physical activity (PA) and cardiorespiratory fitness (CRF) on normal age-related cognitive decline might be sex dependent. Our aim was to explore the relationship between different types of PA, CRF, and cognition and to identify the mediating effects of CRF in the association between PA and cognition in women and men.

Methods
We recruited 115 healthy adults 50–70 yr of age. We obtained demographic, cognitive, and PA status data based on the Projecte Moviment protocol. We calculated cognitive domains by grouping z-sample scores. We obtained self-reported total energy expenditure during the last month and grouped it into sportive PA (S-PA) and nonsportive PA (NS-PA). CRF was estimated using the Rockport 1-Mile Walk Test. We applied regression models and mediation analyses in a final sample of 104 individuals (65 women and 39 men).

Results
In the total sample, CRF was positively associated with executive function, verbal memory, and attention–speed. S-PA was positively related to executive function and attention–speed, whereas NS-PA was unrelated to cognitive domains. Greater amounts of S-PA were associated with executive function and attention–speed for both women and men. Higher CRF was associated with executive function, memory, language, and attention–speed only in men. Mediation analyses showed that CRF was a significant mediator of the positive effects of S-PA on executive function and attention–speed in men but not in women.

Conclusions
Both women and men show cognitive benefits from greater S-PA, but not from NS-PA. However, there were sex differences in the mediating effects of CRF in this relationship, showing that CRF was mediating these benefits only in men.
Risk factors associated with weight gain after kidney transplantation: A cohort study
Authors: Forte Cristina Carra , Pedrollo Elis Forcellini , Nicoletto Bruna Bellincanta , Lopes Jéssica Blatt , Manfro Roberto Ceratti , Souza Gabriela Corrêa , Leitão Cristiane Bauermann 
Published: December 2020

Background
Renal transplantation is the best modality of renal replacement therapy for patients with end-stage renal disease. However, it is associated with weight gain and metabolic abnormalities, which adversely impact transplant outcomes.

Objective
The objective of this study was to identify the risk factors of one-year weight gain after renal transplantation.

Methods
A retrospective cohort study was conducted with 374 patients that underwent kidney transplantation between January 2006 and July 2013. Clinical and laboratory variables were collected from electronic records, and the outcome of interest was weight gain during the first year after renal transplantation. The data were reported as mean ± standard deviation, median (interquartile range) or number of subjects (%). The association between variables were assessed via chi-square test and ANOVA. For analysis of risk factors related to the outcomes of interest, multivariable logistic regression models were used.

Results
There were 181 (48.4%) female patients, 334 (89.3%) with white ethnicity and the mean age was 44.4 ± 12.8 years. The mean BMI pre-transplant was 24.7 ± 4.1 kg/m2, and 35 (9.9%) patients were classified as obese; 119 (33.6%) as overweight; 187 (52.8%) as normal weight; and 13 (3.7%) as malnourished. After one year of follow-up, the mean BMI was 26.2 ± 5.0 kg/m2, and 61 (17.3%) patients were classified as obese; 133 (37.8%) as overweight; 148 (42.0%) as normal weight; and 10 (2.8%) as malnourished. Weight gain was observed in 72.7% patients, and the average increase was 7.12 ± 5.9 kg. The female gender, lower pre-transplant body weight, lower number of hospitalizations, and a kidney received from a living donor were associated with weight gain by more than 5% in the first year post-transplant.

Conclusion
Female gender and lower pre-transplant body weight were independently associated with weight gain by more than 5% in the first year after kidney transplantation; lower rates of hospitalization and donation from living donors were also risk factors for this outcome.
Correlation analysis of the proportion of monocytic myeloid-derived suppressor cells in colorectal cancer patients
Authors: Shirasuna Kenna , Ito Masayuki , Matsuda Takashi , Enomoto Tsuyoshi , Ohara Yusuke , Yamamoto Masayoshi , Nishijima Satomi , Ohkohchi Nobuhiro , Kuromitsu Sadao 
Published: December 2020

Monocytic myeloid-derived suppressor cells (mMDSCs) are a class of immunosuppressive immune cells with prognostic value in many solid tumors. It is reported that the proportion of mMDSCs in the peripheral blood can be a predictive marker for response to cancer immunotherapy. In this study, we performed a correlation analysis of the proportion of mMDSCs in freshly-drawn peripheral blood, levels of plasma proteins, and demographic factors in colorectal cancer (CRC) patients, to find factors that could be used to predict mMDSC proportions. Freshly-drawn mMDSCs were measured using flow cytometry on peripheral blood mononuclear cells (PBMCs) from healthy donors (n = 24) and CRC patients (n = 78). The plasma concentrations of 29 different cytokines, chemokines, growth factors, and enzymes were measured using a multiplex assay or enzyme-linked immunosorbent assay. Correlation analysis to find mMDSC-associated factors was conducted using univariate and multivariate models. In univariate correlation analysis, there were no plasma proteins that were associated with mMDSC proportions in CRC patients. In multivariate analysis, considering all variables including age, sex, and plasma proteins, levels of inducible nitric acid synthase (iNOS) (p = 0.013) and platelet-derived growth factor (PDGF)-BB (p = 0.035) were associated with mMDSC proportion in PBMCs (mMDSC proportion [%] = 0.2929 − 0.2389 * PDGF-BB + 0.3582 * iNOS) (p < 0.005, r = 0.32). Measuring the plasma concentrations of iNOS and PDGF-BB may be useful in predicting the proportion of mMDSCs in CRC patients’ peripheral blood. Further research is required to establish and validate these predictive factors.Data registrationPatient data were registered in an anonymization system at Tsukuba Clinical Research & Development Organization (T-CReDO).
Participation in community-based health care interventions (CBHIs) and its association with hypertension awareness, control and treatment in Indonesia
Authors: Sujarwoto Sujarwoto , Maharani Asri 
Published: December 2020

Background
Little attention has been paid to whether CBHIs improve awareness, treatment and control of hypertension in the contexts of low- and middle- income countries (LMICs). This study therefore aims to examine participation in CBHIs for non-communicable diseases (NCDs) and its association with awareness, treatment, and control of hypertension among Indonesians.

Methods
This study used data from the 2014 Indonesia Family Life Survey (IFLS), drawn from 30,351 respondents aged 18 years and older. Participation in CBHIs was measured by respondents’ participation in CBHIs for NCDs (Posbindu PTM and Posbindu Lansia) during the 12 months prior to the survey. Logistic regressions were used to identify the relationships between participation in CBHIs for NCDs and awareness, treatment, and control of blood pressure among respondents with hypertension.

Results
The age-adjusted prevalence of hypertension was 31.2% and 29.2% in urban and rural areas, respectively. The overall age-adjusted prevalence was 30.2%. Approximately 41.8% of respondents with hypertension were aware of their condition, and only 6.6% of respondents were receiving treatment. Participation in CBHIs for NCDs was associated with 50% higher odds of being aware and 118% higher odds of receiving treatment among adults with hypertension. There was no significant association between participation in CBHIs for NCDs and controlled hypertension.

Conclusion
Our data emphasise the importance of CBHIs for NCDs to improve the awareness and treatment of hypertension in the Indonesian population.
Determinants of cigarette/bidi smoking among youth male in rural Mymensingh of Bangladesh: A cross-sectional study
Authors: Rahman K. M. Mustafizur , Tareque Md. Ismail 
Published: December 2020

Background
Smoking cigarette/bidi, is a serious health threat, causes preventable premature morbidity and mortality. Higher prevalence of smoking among the youth hampers a country’s development, as the youth are the main drivers of socio-economic development. An effective understanding of factors associated with youth smoking is precious to prevent youth smoking. This study aims to identify the determinants of smoking cigarette/bidi among the youth male of the rural areas of Mymensingh district in Bangladesh.

Methods
The primary data from the project “Knowledge, awareness and practices among youth smokers in Trishal Upazila under Mymensingh district: A micro-survey study”, funded by the Research and Extension Center, Jatiya Kabi Kazi Nazrul Islam University, Bangladesh was utilized in the current study. The data consists of 385 youth males aged 15–24 years who were interviewed face-to-face from the rural areas of Mymensingh district in Bangladesh. Univariate distribution, chi-square tests, and binary logistic regression model were employed to identify the factors associated with smoking cigarette/bidi among the youth male.

Results
The prevalence of smoking cigarette/bidi among the youth male is 40.3% [95% CI: 35.0%-45.0%]. Age, occupation, monthly income, family’s monthly income, cigarette/bidi smoking status of father, brother and close friends, and knowledge about harmfulness of smoking are revealed as the determinants of cigarette/bidi smoking. For instance, the odds of being smoker increases with the increase in age (Odds ratio [OR]: 1.33 [1.17–1.51]). Business owner is less likely (OR: 0.15 [0.03–0.68]) to smoke than the day labourer. Having smoker fathers (OR: 2.51 [1.39–4.53]), smoker brothers (OR: 2.88 [1.39–5.96]), smoker friends (OR: 9.85 [5.85–1.27]) are significantly associated with smoking cigarette/bidi.

Conclusion
As the first study, it provides the determinants of cigarette/bidi smoking among youth male of the rural areas of Mymensingh district in Bangladesh. Relevant authorities are suggested to consider the study’s findings and recommendations to revise the existing smoking policies so that smoking among youth can be prevented for future development of the country.
Non-invasive myocardial work is reduced during transient acute coronary occlusion
Authors: Sabatino Jolanda , De Rosa Salvatore , Leo Isabella , Spaccarotella Carmen , Mongiardo Annalisa , Polimeni Alberto , Sorrentino Sabato , Di Salvo Giovanni , Indolfi Ciro 
Published: December 2020

Background
During ischemia a close relationship exists between sub-endocardial blood flow and myocardial function. Strain parameters can capture an impairment of regional longitudinal function but are load dependent. Recently, a novel non-invasive method to calculate Myocardial Work (MW) showed a strong correlation with invasive work measurements.
Our aim was to investigate the ability of non-invasive MW indices to identify the ischaemic risk area during transient acute coronary occlusion (TACO).

Methods and results
The study population comprises 50 individuals with critical coronary stenosis (CCS). Echocardiography recordings were obtained before coronary angiography, during TACO and after revascularization to measure global longitudinal strain (GLS), Myocardial Work Index (MWI), Myocardial Constructive Work (MCW), Myocardial Wasted work (MWW), Myocardial work efficiency (MWE).
Compared to baseline, we found a significant reduction of GLS (p = 0.005), MWI, MCW and MWE (p<0.001) during TACO.

Conclusions
The non-invasive measurement of MW parameters is a sensitive and early marker of myocardial ischemia during TACO.
Factors associated with psychological distress during the coronavirus disease 2019 (COVID-19) pandemic on the predominantly general population: A systematic review and meta-analysis
Authors: Wang Yeli , Kala Monica Palanichamy , Jafar Tazeen H. 
Published: December 2020

Background
The Coronavirus Disease 2019 (COVID-19) outbreak has escalated the burden of psychological distress. We aimed to evaluate factors associated with psychological distress among the predominantly general population during the COVID-19 pandemic.

Methods
We searched PubMed, EMBASE, Scopus, Cochrane Library, PsycINFO, and World Health Organization COVID-19 databases (Dec 2019–15 July 2020). We included cross-sectional studies that reported factors associated with psychological distress during the COVID-19 pandemic. Primary outcomes were self-reported symptoms of anxiety and depression. Random-effects models were used to pool odds ratios (OR) and 95% confidence intervals (CI). The protocol was registered in PROSPERO (#CRD42020186735).

Findings
We included 68 studies comprising 288,830 participants from 19 countries. The prevalence of anxiety and depression was 33% (95% CI: 28%-39%) and 30% (26%-36%). Women versus men (OR: 1.48 [95% CI: 1.29–1.71; I2 = 90.8%]), younger versus older (< versus ≥35 years) adults (1.20 [1.13–1.26]; I2 = 91.7%), living in rural versus urban areas (1.13 [1.00–1.29]; I2 = 82.9%), lower versus higher socioeconomic status (e.g. lower versus higher income: 1.45 [1.24–1.69; I2 = 82.3%]) were associated with higher anxiety odds. These factors (except for residential area) were also associated with higher depression odds. Furthermore, higher COVID-19 infection risk (suspected/confirmed cases, living in hard-hit areas, having pre-existing physical or mental conditions) and longer media exposure were associated with higher odds of anxiety and depression.

Interpretation
One in three adults in the predominantly general population have COVID-19 related psychological distress. Concerted efforts are urgently needed for interventions in high-risk populations to reduce urban-rural, socioeconomic and gender disparities in COVID-19 related psychological distress.
Programas de intervención a través de Internet para la reducción de peso en adultos con sobrepeso y obesidad: una revisión sistemática
Authors: Mata-González Edith Ernestina , Meza-Peña Cecilia , Saldaña García Carmina 
Published: December 2020

Introducción: el auge de la tecnología ha posibilitado el desarrollo de programas vía Internet para abordar el problema de la obesidad, como apoyo complementario a programas presenciales. El presente estudio evalúa la evidencia sobre programas vía Internet realizados en personas adultas con sobrepeso y obesidad, analizando los recursos y componentes principales de las intervenciones. Material y métodos: Se realizó una revisión sistemática en las bases de datos Web of Science y Scopus. Se seleccionaron estudios de intervención en línea para la reducción de peso en población adulta. Bajo los lineamientos PRISMA, se analizó la información extrayendo datos de autoría, año de publicación, diseño del estudio, duración de la intervención, variables para evaluar la eficacia y resultados. Resultados: Se analizaron 21 artículos, mismos que reportan diferencias significativas en peso tras intervención en línea contrastados con modalidades presenciales o grupos control. Los programas enfatizan cambios en dieta, incremento de actividad física, auto monitoreo, fijación de metas y disponibilidad de redes sociales como variables que garantizan eficacia. La retroalimentación por parte de profesionales y las redes de apoyo parecen ser cruciales para la adherencia y el logro de reducciones de peso significativas. Conclusiones: El aprovechamiento de la tecnología puede ser un aliado que lleve a cambios significativos en el peso de personas que viven con sobrepeso u obesidad.
Vir a Ser Outro por Meio das Narrativas do Vivido
Authors: Pereira Marcemino Bernardo 
Published: December 2020

RESUMO
Este trabalho narra experiências de um professor de História do Ensino Fundamental na rede municipal de Campinas – SP. São histórias amparadas em lembranças, produções de alunos e registros de aula do autor e que dialogam, basicamente, com as reflexões de Walter Benjamin sobre a memória e a escrita narrativa. Trata-se de uma investigação no campo da educação narrada em primeira pessoa, problematizando o ensino de história por meio de documentos e escrita de textos de opinião, bem como os percursos formativos do professor. As várias histórias aqui narradas se entretecem na construção de sentidos para prática docente que emergem à medida que se conta, produzindo saberes entendidos como lições do vivido.
Palavras-chave: Pesquisa narrativa; Ensino de história; Saberes docentes; Saberes da experiência; Alteridade.

ABSTRACT
This work narrates the experiences of a history teacher of elementary education in the municipal network of Campinas - SP. They are stories based on memories, student productions and class records of the author and that dialogue, basically, with Walter Benjamin's reflections on memory and narrative writing. This is an investigation in the field of education narrated in the first person, problematizing the teaching of history through documents and writing of opinion texts, as well as the formative paths of the teacher. The various stories narrated here interweave in the construction of meanings for teaching practice that emerge as one tells, producing knowledge understood as lessons from the experience.
Keywords: Narrative research; History teaching; Teaching knowledge; Knowledge of experience; Alterity.
A Moça Moderna nas Fotografias da Escola de Economia Rural Doméstica de Uberaba (ESERD)
Authors: Vieira Carneiro Juno Alexandre 
Published: December 2020

Discute-se os lugares e papeis sociais reservados à figura feminina na ESERD, por meio do estudo das fotografias produzidas pela instituição e preservadas no arquivo histórico do IFTM. Nesse sentido, percebe-se uma situação pendular, ora estimulando a emancipação das alunas, de forma a contribuírem para o desenvolvimento econômico através da gestão científica do lar e da família, ora limitando-as, mediante a manutenção de valores tradicionais com vistas à reprodução de padrões éticos e morais.