bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whole Genome Analysis of Extensively Drug-Resistant Acinetobacter baumannii Clinical Isolates in Thailand
Authors: Chopjitt Peechanika , Kerdsin Anusak , Takeuchi Dan , Hatrongjit Rujirat , Boueroy Parichart , Akeda Yukihiro , Tomono Kazunori , Hamada Shigeyuki 
Published: November 2020

Background::
Acinetobacter baumannii is recognized as a majority opportunistic nosocomial
pathogen causing hospital-acquired infection worldwide. The increasing prevalence of extensively
drug-resistant Acinetobacter baumannii (XDRAB) has become a rising concern in healthcare
facilities and has impeded public health due to limitation of therapeutic options and are associated
with high morbidity and mortality as well as longer hospitalization. Whole-genome sequencing
of highly multidrug resistant A. baumannii will increase the understanding of resistant mechanisms,
the emergence of novel resistance, genetic relationships among the isolates, source tracking,
and treatment decisions in selected patients.

Objective::
This study revealed the genomic analysis to explore blaOXA-23 harboring XDRAB isolates
in Thailand.

Methods::
Whole-genome sequencing of the two XDRAB isolates was carried out on a HiSeq2000
Illumina platform and susceptibility on antimicrobials was conducted.

Results::
Both isolates revealed sequence types of international, clone II-carrying, multiple antimicrobial-
resistant genes—ST195 and ST451. They were resistant to antimicrobial agents in all drug
classes tested for Acinetobacter spp. They carried 18 antimicrobial-resistant genes comprising of 4
β-lactamase genes (blaOXA-23, blaOXA-66, blaTEM-1D, blaADC-25), 4 aminoglycoside-resistant genes (armA,
aph(3')-Ia, aph(3”)-Ib, aph(6)-Id), 3 macrolide-resistant genes (amvA, mphE, msrE), 1 sulfonamide-
resistant gene (sul-2), 2 tetracycline-resistant genes (tetB, tetR), 1 resistant-nodulation-cell
division (RND) antibiotic efflux pump gene cluster, 2 major facilitator superfamily (MFS) antibiotic
efflux pump genes (abaF, abaQ), and 1 small multidrug-resistant (SMR) antibiotic efflux pump
gene (abeS). Mutation of gyrA (S81L) occurred in both isolates.

Conclusions::
Whole-genome sequencing revealed both blaOXA-23 harboring XDRAB isolates were
clustered under international clone II with different STs and carrying multiple antimicrobial-resistant
genes conferred their resistance to antimicrobial agents. Inactivation of antimicrobials and target
modification by enzymes and pumping antibiotics by efflux pump are mainly resistance mechanism
of the XDRAB in this study.
Comparative Study between the Uses of High Dose Corticosteroid Therapy for Short Duration Versus Low Dose Corticosteroid for Long Duration in Severe Lung Contusion with ARDS
Authors: Gaber Ibrahim Mostafa Allam Mohamed 
Published: November 2020

Introduction:
Corticosteroids are used in ARDS to prevent lung fibrosis. The best dose, duration and regimen are still the points of debate among physicians.

Aim of the Work:

The aim of this study is to make a comparison between two corticosteroid regimens, i.e. short-duration high dose versus long- duration low dose corticosteroid use in ARDS due to lung contusion with VAP for lowering both morbidity and mortality rates and early weaning from ventilator.

Patients and Methods:
Patients who had >3 on Murray score and >6 on CPIS were allocated randomly in two groups of 120 patients each. Group A received 30 mg/kg methyl-prednisolone slowly intravenously in 250 ml normal saline every 8 hours for only 48 hours, while group B received 1 mg/kg/day methyl-prednisolone divided into three doses given every 8 hours for two weeks. The study lasted for 16 days; morbidity was considered if no improvement was observed in any or all clinical parameters of both Murray and CPIS scores and if there was failure in removing patients from the ventilator within the studied period.

Results:
Significant improvement was observed in patients of group B compared to group A with regard to APACH II <10 score, arterial oxygen saturation>95, hypoxic index >300, lung infiltrate in chest X-ray, lung compliance, response of the lung to recruitment maneuver, the return of core temperature to normal, normal tracheal secretion, the return of leucocytic count to normal, negative qualitative sputum culture and a significantly higher number of patients were removed from the ventilator of group B compared to group A. However, mortality rate was not significant between the two groups.

Conclusion:

Low dose corticosteroid if used for a long duration significantly lowers morbidity and accelerates recovery, and in turn, accelerates weaning from ventilator compared to high dose corticosteroid used for a short duration. While the difference between the two regimens was not significant with regard to the mortality rate, still further studies are needed to emphasize a fixed corticosteroid dose and regimen in ARDS due to lung contusion.
Pulse-oximetry Derived Perfusion Index as a Predictor of the Efficacy of Rescue Analgesia After Major Abdominal Surgeries
Authors: Saleh Ashraf Nabil , Mostafa Raham Hasan , Hamdy Ahmad Nabil , Hafez Amr Fouad 
Published: November 2020

Study Objective:
The use of an easy to apply reliable tool is essential to assess pain in patients in intensive care units. This study aimed primarily to evaluate perfusion index usefulness as an objective indicator of pain.

Methods and Measurements:
Data were collected from 40 non-intubated adult patients admitted to the surgical intensive care unit postoperatively. The Masimo pulse co-oximetry perfusion index (PI) probe was attached to the patient. At the time of the first request for analgesia (T1), the Behavioural pain scale non-intubated scoring system (BPS-NI) was recorded with the PI and patients' haemodynamics following which rescue analgesia was given. Thirty minutes thereafter (T2), second measurements for the mentioned parameters were taken.

Main Results:
There was a statistically significant reduction in the BPS-NI score, blood pressure and heart rate after analgesic administration (P-values, <0.001, 0.039 and 0.001, respectively), together with a significant increase in the PI (P-value, 0.004). This means that the PI increases with adequate relief from pain, as indicated by a decrease in BPS-NI score and haemodynamics, but the correlation was not statistically significant between their changes.

Conclusion:

There was no statistically significant correlation between the PI and the pain score or other clinical indicators of pain either before or after the administration of analgesic.
Ponto nuclear: poder e papel do Estado.
Authors: Domingos Guilherme Afif 
Published: November 2020

“Em primeiro lugar, quero agradecer a todos por esta oportunidade de participar de um seminário de tanta importância para o momento que nós estamos vivendo, onde fomos aqui brindados, nesses dias, e especialmente no dia de hoje, por duas presenças internacionais do melhor gabarito, que vêm exatamente para trazer a sua contribuição através da sua inteligência e da sua experiência em seus países, e pela presença de companheiros dos meios de comunicação e da Câmara e do Senado, que conosco somam neste grande momento da vida nacional. Em primeiro lugar,
Development of a Personalized Mobile Mental Health Intervention for Workplace Cyberbullying Among Health Practitioners: Protocol for a Mixed Methods Study
Authors: Kim Yun Jin , Qian Linchao , Aslam Muhammad Shahzad 
Published: November 2020

Background
Workplace cyberbullying harms the psychological and social functioning of professionals working in an organization and may decrease the productivity and efficiency of daily life tasks. A recent study on trainee doctors across 8 different United Kingdom National Health Service trusts found health issues and job dissatisfaction in people who have experienced workplace cyberbullying. This disabling effect is even more noticeable in low-socioeconomic communities within low-income countries. In Malaysia, there is a need to create a personalized mobile mental health intervention program for health care professionals. These programs should be directed to prevent and decrease psychosocial issues and enhance coordination among health care professionals to solve health issues in the community.

Objective
Our main objective is to study the pre-effects and posteffects of the Personalized Mobile Mental Health Intervention (PMMH-I) for workplace cyberbullying in public and private hospitals in Malaysia.

Methods
A hospital-based multimethod multi-analytic evidential approach is proposed, involving social and psychological health informatics. The project has been subdivided into 3 stages, starting with Phase 1, a prevalence study, followed by exploratory studies. Phase 2 consists of a quasi-experimental design, whereas the development of a prototype and their testing will be proposed in Phase 3. Each stage includes the use of quantitative and qualitative methods (mixed-method program), using SPSS (version 26.0; IBM Corp) and Stata (version 16.1; StataCorp) as tools for quantitative research, and NVivo (version 1.0; QSR International) and Atlas.ti (version 9.0.16; ATLAS.ti Scientific Software Development GmbH) for qualitative research.

Results
The results of this study will determine the pre- and posteffectiveness of an integrated PMMH-I for health care professionals. The prototype system platform will be developed and implemented in a public and private hospital. Results from Phase 1 will be published in 2021, followed by the implementation of Phase 2 in subsequent years.

Conclusions
This study will provide evidence and guidance regarding the implementation of a personalized mobile mental health intervention for health care professionals into routine public and private hospitals to enhance communication and resolve conflicts.

International Registered Report Identifier (IRRID)
PRR1-10.2196/23112
Comparing Effectiveness Between a Mobile App Program and Traditional Cognitive Behavior Therapy in Obsessive-Compulsive Disorder: Evaluation Study
Authors: Hwang Hyunchan , Bae Sujin , Hong Ji Sun , Han Doug Hyun 
Published: November 2020

Background
This study proposes a digital program for the treatment of mental illness that could increase motivation and improve learning outcomes for patients. Several studies have already applied this method by using an exposure and response prevention–inspired serious game to treat patients with obsessive-compulsive disorder (OCD).

Objective
We hypothesized that a mobile cognitive behavior therapy (CBT) program would be as effective in treating OCD as traditional offline CBT. In addition, the treatment efficacy in response to mobile CBT for OCD might be associated with increased brain activity within the cortico-striato-thalamo-cortical (CSTC) tract.

Methods
The digital CBT treatment program for OCD, OCfree, consists of 6 education sessions, 10 quests, and 7 casual games. Information was gathered from 27 patients with OCD (15 offline CBT and 12 OCfree CBT). During the 6-week intervention period, changes in clinical symptoms and brain function activity were analyzed.

Results
There was no significant difference in the change in OCD symptoms and depressive symptoms between the two groups. However, the OCfree group showed greater improvement in anxiety symptoms compared to the offline CBT group. Both offline CBT and OCfree CBT increased the functional connectivity within the CSTC tract in all patients with OCD. However, CBT using OCfree showed greater changes in brain connectivity within the thalamus and insula, compared to offline CBT.

Conclusions
OCfree, an OCD treatment app program, was effective in the treatment of drug-naïve patients with OCD. The treatment effects of OCfree are associated with increased brain connectivity within the CSTC tract. Multisensory stimulation by education, quests, and games in OCfree increases the activity within the thalamus and insula in patients with OCD.
Optimized and Robust Design of Tires Based on Numerical Simulation
Authors: Kaliske Michael , Serafinska Aleksandra , Zopf Christoph 
Published: November 2020

ABSTRACT:
This publication presents a numerical approach for analyzing tires based on multiobjective optimization, with particular consideration of uncertainties. Within the optimization, which uses evolutionary algorithms, the evaluation of a three-dimensional, finite element tire model at steady-state rolling is performed. To obtain a reliable and high-quality design, data uncertainty caused, e.g., by variation in production conditions of the tire components, as well as incomplete information concerning loading, have to be considered. Among several design goals, this study looked at durability as an example. An improvement is achieved by the consideration of two objective functions: one focusing on reducing wear, and the other on providing resistance to fatigue. In addition, the proposed optimization measures robustness implicitly. A tire model is regarded as robust when large variations of the uncertain influencing factors mentioned, e.g., loading or material properties, lead to only minor variations in uncertain structural responses, e.g., strains, stresses, or contact pressures. To improve the numerical efficiency of the proposed design approach, a response-surface approximation, based on artificial neural networks, is applied.
“THE JEWISH QUESTION” IN THE PAGES OF CONTIMPORANUL
Authors: FAUR Emilia 
Published: November 2020

The Jewish Question in the Pages of Contimporanul. It is my interest to investigate how one of the Romanian leading interwar avant-garde magazines, Contimporanul (1922-1932), tackled the Jewish question. In this respect, I will consider the various standpoints the contributors took on the matter, presenting it in all its facets and complexity, as both a political and a cultural phenomenon. The analysis of the numerous articles covering the Jewish question, its causes and consequences, is meant to illustrate the sensibility Contimporanul demonstrates in regard to the Jewish question. Finally, I will conclude that, as in all matters covered, the magazines’ ideological position is democratic – For its contributors’ main claim is that the young Romanian state should prove itself to be united, modern, democratic based on the principles of integration and plurality, and not a nation-state based on ethnic and religious discrimination.
Regulation of the Activities of Pilots and Pilot Societies in Pre-revolutionary Russia
Authors: Koval V. N. 
Published: November 2020

INTRODUCTION. The article analyzes the content of the main legislative acts regulating the activities of pilots and pilot societies in pre-revolutionary Russia. The relevance of the research is provided by the lack of knowledge in domestic science of the specifics of legal regulation of the pilot service in the Russian state in the pre-revolutionary period.MATERIALS AND METHODS. Th main sources of the research were normative documents, first of all, legislative acts of national significance, dedicated to commercial navigation and published in The Complete Collection of Laws of the Russian Empire and Code of Laws of the Russian Empire, which regulated the issues of financial security and social status of pilots in the Russian Empire, their responsibility. The methodology consists of the principles used in legal research, as well as general scientific and special methods of legal research (comparative legal, system, formal legal methods, historical and legal analysis).RESEARCH RESULTS. The Russian experience of regulatory regulation of pilotage is studied: The Maritime Regulations of 1722, the Regulations on Sea Pilots of 1890, the Charter of the Society of Saint Petersburg Pilots of 1896 and other legal acts of this period are considered. The specifics of legal regulation of the pilot service in pre-revolutionary Russia are established.DISCUSSION AND CONCLUSIONS. It is noted that the regulation of pilot companies as one of the trade unions was carried out under the control of the state. It is stated that the legislation of the Russian Empire, which determines the status of a pilot in the period of the XVIII–XIX century, was, in comparison with the legislation of European States, secondary and in many respects lagging behind the latter. The author focuses on how the structural organization of the pilot service and its legal status changed with the development of legislation.
International Legal Problems of Cooperation in the Detection, Investigation and Prevention of Crimes Committed Using Information and Telecommunication Networks and in the Field of Computer Information
Authors: Arkhipova E. A. , Dodonov V. N. 
Published: November 2020

INTRODUCTION. Based on the analysis of international acts, as well as the practice of their application, the authors consider the international legal problems of interaction in the detection, investigation and prevention of crimes committed using information and telecommunication networks and in the field of computer information.MATERIALS AND METHODS. The materials for the study include the Agreement on cooperation of the CIS member States in the fight against crimes in the field of computer information of June 1, 2001, the Agreement on cooperation of the CIS member States in the fight against crimes in the field of information technology of September 28, 2018, as well as other international legal documents in this area. The paper uses comparative, comparative-historical and other scientific methods of research, general and particular ones.RESEARCH RESULTS. The result of the study is a general assessment of the state of the international legal framework for the interaction of countries in the detection, investigation and prevention of crimes in the information and telecommunication sector, as well as an analysis of the part of it that has legal force for the Russian Federation. The structure, problems and directions of development of international legal regulation in this area are revealed.DISCUSSION AND CONCLUSIONS. Based on the problematic analysis of the current experience of international legal regulation of cooperation in the fight against crimes committed using information and telecommunication networks and in the field of computer information, the authors concluded that the existing international legal framework for such cooperation is insuffi ent and needs to be improved both at the universal and regional level.
Foreign banks management in the context of a pandemic: problems and solutions
Authors: Niyazbekova Sh. U. 
Published: November 2020

The article discusses the problems encountered by enterprises in the financial sector in the context of the COVID-19 pandemic. The paper gives examples of management actions of the largest banks in Italy, Brazil, South Korea, China, Portugal, Singapore, the USA, the Philippines and Russia. World Health Organization has advised the population to use contactless payments and reduce the turnover of banknotes to a minimum. The coronavirus has increased the desire of customers to use digital services, making it an urgent need. In fact, the pandemic has led to the fact that Bank customers, who are increasingly afraid to spend time in public places, should be able to conduct banking operations without physical interaction with Bank offices. By implementing fully digital remote customer service, banks must ensure that both routine and unique (one-time, specific) banking processes will be performed without loss or disruption. Under these circumstances, financial institutions will be required to disclose information about the impact of the coronavirus pandemic on their operations in financial statements based on the relevant disclosure standards (Generally Accepted Accounting Principles, GAAP and United States Securities and Exchange Commission, SEC). Disclosure of financial statements may include risk factors such as Fund depreciation, reduced liquidity, and other aspects.The downward trend in interest rates as required by governments and national banking regulators may affect the profitability of banks. Along with a General decline in business activity, this will lead to a decrease in Bank profits. Analysts’ concerns have already resulted in a sharp drop in the share prices of many firms, which creates another problem because some deferred tax assets, such as net operating losses (NOL), are not fully accounted for in the Bank’s regulatory capital requirements. National governments impose industry-specific tax requirements on capital market enterprises, but the challenges they will face when filing and paying direct and indirect taxes are likely to be similar to those faced by other industries.
"Quimemizando" a Matemática: o estudo do Cálculo Diferencial e Integral em um curso de Licenciatura em Química
Authors: Carius Ana Carolina , Júnior Ricardo Lopes de Souza , Alegre Lucas Gomes 
Published: November 2020

O presente trabalho apresenta os resultados de uma pesquisa desenvolvida na disciplina de Cálculo Diferencial e Integral para funções de uma variável em um curso de Licenciatura em Química. Modificações nas práticas pedagógicas do professor de Matemática que atua na disciplina de Cálculo Diferencial e Integral, integrando-a melhor à Química e às aspirações dos estudantes do curso são o objeto deste estudo. Foi elaborado um material didático interdisciplinar em Cálculo Diferencial e Integral e Química, e este, em conjunto com a Abordagem Baseada em Problemas (ABP), garantiu a oferta de um curso de Cálculo Diferencial e Integral para funções de uma variável diferenciado. Considerando a proposta, o objetivo deste estudo foi avaliar a pertinência desta ao curso de Licenciatura em Química. A partir de um estudo de caso utilizando as técnicas de pesquisa questionário e entrevista, junto aos estudantes que participaram da disciplina, foram realizadas análise quantitativa e qualitativa dos dados coletados. Concluiu-se que a aplicação de conceitos matemáticos à Química, ainda no primeiro ano do curso, contribui para minimizar a retenção na disciplina e incentiva o estudo da Matemática, sendo ainda necessárias outras ações para minimizar a evasão dos estudantes.
INTELLECTUAL CAPITAL IN INNOVATIVE FIRM
Authors: Atan Nurziana Mohd , Sofian Saudah 
Published: November 2020

This research was conducted to investigate the influence of intellectual capital on overall innovation and R&D activities in an innovative firm. The firm is a leader in natural goat’s milk-based cosmetics and health products in Malaysia. Intellectual capital consists of four components, human capital, structural capital, relational capital and spiritual capital. This research was a case study and qualitative approach was applied to gather data. The Marketing Manager, Human Resource Manager, Factory Operation Manager, administrative workers, factory workers, IT personnel and customers of the firm were interviewed. The information from the interviews was analyzed using codes and transcription. Finding of the study indicates that among the intellectual components, structural capital is the highest contributor to the firm’s innovation. Among the recommendations made to the firm are to increase human capital with high expertise, to have a systematic documentation, to cooperate with organization’s external environment and strengthen spiritual value. Future researches are suggested to use instruments other than interviews and widen the scope to more than one firm or industry.