bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel hybrid method named electron conformational genetic algorithm as a 4D QSAR investigation to calculate the biological activity of the tetrahydrodibenzazosines
Authors: Sahin Kader , Saripinar Emin 
Published: February 2020

AbstractTo understand the structure–activity correlation of a group of tetrahydrodibenzazocines as inhibitors of 17β‐hydroxysteroid dehydrogenase type 3, we have performed a combined genetic algorithm (GA) and four‐dimensional quantitative structure–activity relationship (4D‐QSAR) modeling study. The computed electronic and geometry structure descriptors were regulated as a matrix and named as electron‐conformational matrix of contiguity (ECMC). A chemical property‐based pharmacophore model was developed for series of tetrahydrodibenzazocines by EMRE software package. GA was employed to choose an optimal combination of parameters. A model has been developed for estimating anticancer activity quantitatively. All QSAR models were established with 40 compounds (training set), then they were considered for selective capability with additional nine compounds (test set). A statistically valid 4D‐QSAR (, and q2 = 0.650) with good external set prediction was obtained.
Distributed and multicore QuBiLS‐MIDAS software v2.0: Computing chiral, fuzzy, weighted and truncated geometrical molecular descriptors based on tensor algebra
Authors: García‐Jacas César R. , Marrero‐Ponce Yovani , Vivas‐Reyes Ricardo , Suárez‐Lezcano José , Martinez‐Rios Felix , Terán Julio E. , Aguilera‐Mendoza Longendri 
Published: February 2020

AbstractAdvances to the distributed, multi‐core and fully cross‐platform QuBiLS‐MIDAS software v2.0 (http://tomocomd.com/qubils-midas) are reported in this article since the v1.0 release. The QuBiLS‐MIDAS software is the only one that computes atom‐pair and alignment‐free geometrical MDs (3D‐MDs) from several distance metrics other than the Euclidean distance, as well as alignment‐free 3D‐MDs that codify structural information regarding the relations among three and four atoms of a molecule. The most recent features added to the QuBiLS‐MIDAS software v2.0 are related (a) to the calculation of atomic weightings from indices based on the vertex‐degree invariant (e.g., Alikhanidi index); (b) to consider central chirality during the molecular encoding; (c) to use measures based on clustering methods and statistical functions to codify structural information among more than two atoms; (d) to the use of a novel method based on fuzzy membership functions to spherically truncate inter‐atomic relations; and (e) to the use of weighted and fuzzy aggregation operators to compute global 3D‐MDs according to the importance and/or interrelation of the atoms of a molecule during the molecular encoding. Moreover, a novel module to compute QuBiLS‐MIDAS 3D‐MDs from their headings was also developed. This module can be used either by the graphical user interface or by means of the software library. By using the library, both the predictive models built with the QuBiLS‐MIDAS 3D‐MDs and the QuBiLS‐MIDAS 3D‐MDs calculation can be embedded in other tools. A set of predefined QuBiLS‐MIDAS 3D‐MDs with high information content and low redundancy on a set comprised of 20,469 compounds is also provided to be employed in further cheminformatics tasks. This set of predefined 3D‐MDs evidenced better performance than all the universe of Dragon (v5.5) and PaDEL 0D‐to‐3D MDs in variability studies, whereas a linear independence study proved that these QuBiLS‐MIDAS 3D‐MDs codify chemical information orthogonal to the Dragon 0D‐to‐3D MDs. This set of predefined 3D‐MDs would be periodically updated as long as new results be achieved. In general, this report highlights our continued efforts to provide a better tool for a most suitable characterization of compounds, and in this way, to contribute to obtaining better outcomes in future applications.
The stage-specific impairment of granulopoiesis in people living with HIV/AIDS (PLWHA) with neutropenia
Authors: Fan Lina , Han Junyan , Xiao Jiang , Dai Guorui , Hao Yu , Yang Di , Liang Hongyuan , Wu Liang , Song Chuan , Li Guoli , Li Bei , Wang Di , Zeng Yongqin , Pang Xiaoli , Zhang Fujie , Zeng Hui , Zhao Hongxin 
Published: February 2020

Abstract
Neutropenia and impaired functions were common manifestation in antiretroviral therapy (ART) in both naïve and experienced PLWHA. Granulopoiesis can be divided into two phases: lineage determination and committed granulopoiesis. However, stage-specific impairment of granulopoiesis in PLWHA with neutropenia remains unclear. A total of 48 ART-naïve and 49 ART-experienced PLWHA from 2016 to 2018 were recruited and divided into non-, mild-, and moderate-to-severe-neutropenia groups according to their neutrophil counts. The bone marrow aspirates and peripheral blood were collected and analyzed by multicolor flow cytometry for granulocyte subsets, hematopoietic stem/progenitor cells (HSPC), apoptosis, and emigration and retention of different subsets. Compared with healthy donors, the percentages of circulating segmented neutrophils were significantly decreased along with an increase of immature neutrophils in both groups. ART-naïve patients with moderate to severe neutropenia exhibited decreased proportion and accelerated apoptosis of relative mature segmented neutrophils. In contrast, ART-experienced patients with neutropenia displayed decreased proportion of granulocyte macrophage progenitors, indicating a defect at a stage of lineage determination. Meanwhile, ART-experienced patients with neutropenia also the expression of CXCR4 segmented neutrophils, suggesting an increased retention of segmented neutrophils inn the bone marrow. ART-naïve patients with neutropenia is caused by increased apoptosis of relatively differentiated neutrophils at committed granulopoiesis, whereas impaired lineage determination and enhanced retention of segmented neutrophils contribute to in ART-experienced patients.
An investigation into the effect of changing the computed tomography slice reconstruction interval on the spatial replication accuracy of three‐dimensional printed anatomical models constructed by fused deposition modelling
Authors: Searle Ben , Starkey Deborah 
Published: February 2020

AbstractIntroductionThree‐dimensional (3D) printed models can be constructed utilising computed tomography (CT) data. This project aimed to determine the effect of changing the slice reconstruction interval (SRI) on the spatial replication accuracy of 3D‐printed anatomical models constructed by fused deposition modelling (FDM).MethodsThree bovine vertebrae and an imaging phantom were imaged using a CT scanner. The Queensland State Government’s Animal Care and Protection Act 2001 did not apply as no animals were harmed to carry out scientific activity. The data were reconstructed into SRIs of 0.1, 0.3, 0.5 and 1 mm and processed by software before 3D printing. Specimens and printed models were measured with calipers to calculate mean absolute error prior to statistical analysis.ResultsMean absolute error from the original models for the 0.1, 0.3, 0.5 and 1 mm 3D‐printed models was 0.592 ± 0.396 mm, 0.598 ± 0.479 mm, 0.712 ± 0.498 mm and 0.933 ± 0.457 mm, respectively. Paired t‐tests (P < 0.05) indicated a statistically significant difference between all original specimens and corresponding 3D‐printed models except the 0.1 mm vertebrae 2 (P = 0.061), 0.3 mm phantom 1 (P = 0.209) and 0.3 mm vertebrae 2 (P = 0.097).ConclusionThis study demonstrated that changing the SRI influences the spatial replication accuracy of 3D‐printed models constructed by FDM. Matching the SRI to the primary spatial resolution limiting factor of acquisition slice width or printer capabilities optimises replication accuracy.
A new intelligent scheme for power system faults detection and classification: A hybrid technique
Authors: Balakrishnan Pappan , Gopinath Singaram 
Published: February 2020

AbstractThis paper proposes a hybrid technique to detect and classify the transmission line faults in the power system. The proposed approach is the joint execution of linear discriminant analysis (LDA) and cuttlefish optimizer (CFO) learning process‐based random forest algorithm (RFA), ie, named as LDA‐CFRFA technique. Here, two modules are utilized for fault analysis in power system: fault detection and fault classification. The first procedure of the proposed method is the power system transmission line parameters in normal and abnormal condition dataset preparation by using LDA. LDA‐based dataset preparation process consists of feature extraction of power flow parameters and defines the nature of signals occurred by the system. The extracted dataset is assessed by CFO‐based RFA technique for classifying the fault type occurred in the transmission system. By then, the proposed model is executed in MATLAB/Simulink working stage, and the execution is assessed with the existing techniques such as CFO, RFA, Feed forward neural network (FNN), and artificial neural network (ANN). In our research, the faults implemented on test system are phase A, phase B, phase C, phase A to ground (AG), phase B to ground (BG), phase C to ground (CG), phase AB, phase AC and phase BC, phase AB to ground (ABG), phase AC to ground (ACG), and phase BC to ground (BCG). From the results, the proposed technique guarantees the system with less complexity and less consumption time for the detection and classification of the fault, and hence, the accuracy of the system is increased.
Accelerated degradation of collagen membranes in type 1 diabetic rats is associated with increased expression and production of several inflammatory molecules
Authors: Zoabi Hasan , Nemcovsky Carlos E. , Bender Omer , Moses Ofer , Weinreb Miron 
Published: February 2020

AbstractBackgroundMembrane durability is critical for regenerative procedures. We reported previously that type 1‐like diabetes in rats accelerates the degradation of collagen membranes and we tested here whether this is associated with increased local production of inflammatory molecules as part of a diabetes‐induced chronic inflammation around and within the membranes.MethodsCollagen membrane discs were implanted under the scalp in diabetic (streptozotocin‐induced) and control rats, which were sacrificed after 2 or 3 weeks. Total RNA and proteins were isolated from the membrane and its surrounding tissues and the expression and production of six inflammatory molecules (interleukin‐6 [IL‐6], tumor necrosis factor alpha [TNFα], matrix metalloproteinase [MMP]‐9, macrophage migration inhibitory factor [MIF], MIP‐1α, and MIP‐2α) was measured using real‐time PCR and western blotting, respectively. Minimal histological analysis of the membranes was conducted to conform to previous studies.ResultsHyperglycemia resulted in reduced membrane thickness (by 10% to 25%) and increased mononuclear infiltrate inside the membrane. mRNA and protein levels of IL‐6, TNFα, and MMP‐9 were elevated in diabetic rats both 2 and 3 weeks post‐surgery. The levels (both mRNA and protein) of MIF were increased at 2 weeks post‐surgery and those of MIP‐1α and MIP‐2α at 3 weeks. There was a very good match in the temporal changes of all examined genes between the mRNA and protein levels.ConclusionsElevated local production of inflammatory cytokines and MMPs, together with apparent mononuclear infiltrate and increased collagenolysis confirm that hyperglycemia leads to a chronic inflammation in and around the implanted collagen membranes, which reduces membrane longevity.
Implementation and evaluation of an antimicrobial stewardship program across nine hospitals in the United Arab Emirates: a qualitative study
Authors: Hamdan Samah , El‐Dahiyat Faris 
Published: February 2020

AbstractBackgroundAntimicrobial resistance is at the top of the World Health Organization's agenda. Subsequently, antimicrobial stewardship (AMS) programs are being implemented worldwide. However, there is a lack of literature on AMS programs in the United Arab Emirates (UAE).AimThis study investigated AMS program activities and barriers and limitations to effective implementation of AMS programs within hospitals in Abu Dhabi.MethodsA qualitative study was conducted comprising semistructured interviews using a developed guide. Nine pharmacists from nine government and private hospitals were interviewed. All interviews were transcribed and analysed thematically.ResultsAnalysis of the interviews revealed five main themes: (1) institutional experiences of functional AMS programs in Abu Dhabi, with the greatest capacity for AMS programs found within government hospitals; (2) considerable agreement on the types of AMS program strategies used in hospitals; (3) an instrumental role of clinical pharmacists in the success of sustainable AMS programs; (4) effects of AMS programs on improving antimicrobial prescribing patterns and clinical outcomes; and (5) lack of clinical pharmacists and highly skilled staff as the main barrier to AMS program implementation.ConclusionThis study reveals the variable levels of AMS program implementation within Abu Dhabi hospitals. Participants reported excellent adoption of AMS programs by government hospitals compared with private sector hospitals. Participants also identified a lack of clinical pharmacists and highly skilled staff as the main limitations in AMS program implementation.
Consumer rejection threshold, acceptability rates, physicochemical properties, and shelf‐life of strawberry‐flavored yogurts with reductions of sugar
Authors: Torrico Damir D , Tam Jennifer , Fuentes Sigfredo , Gonzalez Viejo Claudia , Dunshea Frank R 
Published: February 2020

AbstractBACKGROUNDThere is an increasing demand for reduced‐sugar products due to the worldwide prevalence of obesity, diabetes, and cardiovascular diseases. The aim of this study was to evaluate the effects of sugar (sucrose) reductions on the acceptability, preference, and quality of strawberry‐flavored yogurts. A consumer rejection threshold test and an acceptability test (N = 53) were conducted using six yogurt samples with decreasing concentrations of sugar (12–5/100 g). Additional physicochemical tests (pH, °Brix, water‐holding‐capacity, viscosity, and color) were conducted to examine the quality and shelf‐life of strawberry‐flavored yogurts with reductions of sucrose during 28 days of storage at 4 °C.RESULTSReduction of sucrose affected the acceptability and physicochemical characteristics of yogurts. The consumer rejection threshold showed that sucrose in strawberry‐flavored yogurts could be reduced to 5.25/100 g from an initial concentration of 12/100 g without affecting the preferences of consumers. The 71%‐sucrose (8.50/100 g of yogurt) was perceived as the most liked (6.27 using a nine‐point hedonic scale) and the most preferred (rank sum = 127.50) yogurt sample. For the physicochemical properties of yogurts, the viscosity (3263–5473 cP) decreased, and the color lightness (80.98–85.44) increased during 28 days of storage at 4 °C.CONCLUSIONPhysicochemical properties and preferences were affected by the reduction of sugar. The consumer rejection threshold analysis showed that sucrose can be reduced to less than half of the initial concentration. These findings are useful to understand consumers' acceptability and shelf‐life of yogurts with reduced‐sugar formulations in the developing of new products. © 2020 Society of Chemical Industry
Outcome of Salvage Therapy in Isolated Regional Recurrence in Head and Neck Squamous Cell Carcinoma
Authors: Giger Roland , Fink Raffael , Demattè Marco , Visini Miranda , Elicin Olgun , Anschuetz Lukas 
Published: February 2020

Objectives/HypothesisHead and neck squamous cell carcinoma (HNSCC) has a high tendency for regional lymphatic spreading. Nevertheless, isolated regional lymph node recurrences are rare, and only limited data regarding its management are available. The aim of this study was to describe treatment modalities and outcomes, and to identify prognostic factors.Study DesignRetrospective cohort study.MethodsThe records of all patients (n = 498) with tumor persistence or recurrence after curatively intended treatment for HNSCC were retrospectively reviewed. Patients with synchronous secondary tumors at initial presentation, tumor persistence, local or locoregional recurrence, and systemic metastases were excluded.ResultsA total of 76 patients were included. The rate of occult additional metastasis in radiologically uninvolved neck compartments during salvage neck dissection was 25%. The salvaged patients showed a 37.5% 5‐year recurrence‐free survival (RFS). Multivariate analysis revealed initial stage IVA‐B (hazard ratio [HR]: 4.16, P < .01), extracapsular spread (HR: 3.71, P = .04), higher involved/total lymph node ratio (HR: 6.79, P < .01), and soft‐tissue infiltration (HR: 3.27, P < .01) as independent adverse prognostic factors for RFS. Moreover, univariate data analysis identified recurrent stage rcN2‐3; clinical involvement of the neck levels IV, V and/or VI; and smoking as adverse risk factors for RFS.ConclusionsThis study identifies initial stage IVA‐B, extracapsular spread, higher involved/total lymph node ratio, and soft‐tissue infiltration as independent adverse prognostic factors for RFS following isolated regional recurrences. The incidence of occult additional metastasis of radiologically uninvolved levels during salvage neck dissections was high (25%). Therefore, superselective or selective neck dissection would not have been the adequate type of salvage surgery.Level of Evidence4 Laryngoscope, 131:67–72, 2021
Tanshinol A Ameliorates Triton‐1339W‐Induced Hyperlipidemia and Liver Injury in C57BL/6J Mice by Regulating mRNA Expression of Lipemic‐Oxidative Injury Genes
Authors: Li Yuting , Chen Yuxing , Huang Xuejun , Huang Dane , Gan Haining , Yao Nan , Hu Zixuan , Li Ruyue , Zhan Xinyi , Xie Kaifeng , Jiang Jieyi , Cai Dake 
Published: February 2020

AbstractTanshinol A, which is derived from a traditional Chinese herbal Radix Salviae Miltiorrhizae is indicative of a hypolipidemic candidate. Therefore, we aim to validate its hypolipidemic activity of tanshinol A and explore its mechanism in triton‐1339W‐induced hyperlipidemic mice model, which possess multiply pathogenesis for endogenous lipid metabolism disorder. Experimental hyperlipidemia mice are treated with or without tanshinol A (i.g. 40, 20, 10 mg/kg), and blood and liver tissue were collected for validating its hypolipidemic and hepatic protective effect, and hepatic mRNA expression profile, which was associated with lipid metabolism dysfunction and liver injury, was detected by RT‐qPCR. As results show, triton‐1339W‐induced abnormal of serum TC, TAG, HDL‐C, LDL‐C, SOD, MDA, GOT, and GPT is remarkably attenuated by tanshinol A. In pathological experiment, triton‐1339W‐induced hepatocellular ballooning degeneration, irregular central vein congestion, and inflammation infiltration are alleviated by tanshinol A. Correspondingly, hepatic mRNA expression of Atf4, Fgf21, Vldlr, Nqo1, Pdk4, and Angptl4, which are genes regulating lipemic‐oxidative injury, are significantly increased by tanshinol A by 2~6 fold. Abcg5, Cd36, and Apob, which are responsible for cholesterol metabolism, are mildly upregulated. Noticeably, triton‐1339W‐suppressed expressions of Ptgs2/Il10, which are genes responsible for acute inflammation resolution in liver injury, are remarkably increased by tanshinol A. Conclusively, tanshinol A exerted hypolipidemic effect and hepatoprotective effect through restoring triton‐1339W‐suppressed mRNA expression, which may be involved in Atf4/Fgf21/Vldlr and Ptgs2/Il‐10 signaling pathways.
Adipogenic and Myogenic Potentials of Chicken Embryonic Fibroblasts in vitro: Combination of Fatty Acids and Insulin Induces Adipogenesis
Authors: Kim Dong‐Hwan , Lee Joonbum , Suh Yeunsoo , Cressman Michael , Lee Sang Suk , Lee Kichoon 
Published: February 2020

AbstractThe regulation of adipocyte differentiation is an important factor for production efficiency and meat quality in the poultry industry. The purpose of this study was to develop a new in vitro model of adipogenic differentiation of chicken embryonic fibroblasts (CEF). In this study, CEF were isolated at embryonic day (E) 5, and adipogenic differentiation was induced with supplementation of fatty acids (FA) and/or insulin (Ins) for 48 h. Oil‐Red‐O staining showed that lipid accumulation in E5 CEF was greater when supplemented with a combination of FA and Ins (FI) than other treatment groups (p < 0.05). Genes involved in differentiation of preadipocytes, fatty acid transport, and triacylglycerol synthesis were upregulated in the FI group compared to all other treatment groups (p < 0.01). Under myogenic media, the E5 CEF formed myotubes and expressed myogenic markers, myosin heavy chain (MHC), and myogenin (MyoG), suggesting myogenic potential of E5 CEF. To determine the permissive age window for adipogenic differentiation of CEF, E5, E6, and E7 CEF were induced for adipogenesis with FI treatment in 1%, 5%, or 10% chicken serum (CS). Among all embryonic ages, E5 with 10% CS showed the most lipid accumulation and the least myotube formation with the lowest expression of MHC and MyoG. These data indicate both adipogenic and myogenic potentials of E5 CEF, providing a new in vitro model for a better understanding of the processes of adipogenic and myogenic differentiation in chickens.
Influences of impulse excitation and vibration on thermoelastohydrodynamic characteristics of spur gear drive
Authors: Huang Xingbao , Yang Bintang , Wang Youqiang , Zhou Changjiang 
Published: February 2020

AbstractIn this paper, an elastohydrodynamic impact model is proposed, and the prediction of lubricating film performance considering squeeze effect and thermal effect is presented. Effects of sinusoidal impulse load, sinusoidal impulse entrainment velocity, multi‐frequency vibration, and acoustic noise on thermo‐mechanical characteristics of gear lube are numerically investigated. Results show that both sinusoidal impulse load and sinusoidal impulse entrainment velocity can cause remarkable increases in central film thickness and minimum film thickness and induce small reduction in friction coefficient. The sinusoidal impulse load causes considerable increase in central film pressure; however, the sinusoidal impulse entrainment velocity induces significant decrease in central film pressure. The multiple high constant frequency vibration causes considerable increment in film pressure, but maintains small fluctuation in film thickness. Additionally, the consequence of multiple high constant frequency vibration induces evident reduction in friction coefficient.
Wideband circular cavity‐backed slot antenna with conical radiation patterns
Authors: Kumar Arvind 
Published: February 2020

AbstractThis paper presents a wideband low‐profile cavity backed slot antenna for wireless transmission. A low‐profile cavity antenna comprises a circular substrate integrated waveguide (SIW) based backed cavity and octa‐star shaped slot on top as a radiating element fed by a coax probe feed at the center of the cavity. The antenna executes a wide impedance bandwidth response due to dual resonance of octa‐star slot when excited by probe feed. To validate the design concept, a prototype has been manufactured and measured, which displays a −10 dB impedance bandwidth of 16.35%, extending from 9.26 to 11.02 GHz with the flat gain and conical radiation characteristics. Owing to the single layered integrated cavity, this antenna can be easily mounted with other radio frequency (RF) circuitry.