bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mesh Sling Arm Removal for Persistent Pain After an Initial Vaginal Suburethral Mesh Sling Removal Procedure
Authors: Fuentes Jorge L. , Finsterbusch Carlos , Christie Alana L. , Zimmern Philippe E. 
Published: November 2020

Objectives
Pain is a recognized complication of mid-urethral slings (MUS), which may lead to suburethral sling removal (SSR) alone, or to a more extensive removal approach. We report on the outcomes of women who required an SSR or an additional secondary MUS arm removal for pain only.

Methods
After Institutional Review Board (IRB) approval, the charts of nonneurogenic women who underwent SSR for pain only were reviewed. Demographic information, MUS type, self-reported pain resolution, and preoperative and postoperative questionnaires, including Urogenital Distress Inventory-Short form question 6 (UDI-6 Q6) scores, were collected for the SSR (group 1) and secondary removal (group 2) groups.

Results
Of 52 women who underwent SSR for pain only between 2005 and 2018, 16 (31%) required a secondary procedure to remove the extension arms due to persistent pain after SSR. All women in group 2 experienced pain immediately after SSR (UDI-6 Q6 score of 2 to 3). Patients whose pain improved after SSR presented at a median 61 months after MUS whereas those in group 2 underwent SSR at median 34 months after MUS. Median duration of follow-up in group 2, after the secondary procedure, was 34 months. Over one half of those in group 2 (54%) noticed pain cure/improvement. Seven were left with persistent pain.

Conclusions
In women who underwent SSR for pain only, 67% reported pain resolution. An additional procedure to remove the extension arms of the mesh was performed in one third of women for persistent pain after SSR.
The Effect of a Diagnosis on Patients With Interstitial Cystitis/Bladder Pain Syndrome: A Qualitative Approach
Authors: Volpe Katherine A. , Komatsu Emi , Rodriguez Larissa V. , Dancz Christina E. , Pahwa Avita K. 
Published: November 2020

Introduction
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic pain condition that significantly affects patient quality of life. We investigated whether receiving a formal medical diagnosis of IC/BPS was perceived by patients to improve symptoms and disease-specific quality of life.

Methods
Participants with self-reported IC/BPS completed publicly available online surveys. Surveys included demographic information, validated questionnaires, and a free-text response. Participants were asked to comment on the utility of obtaining a diagnosis. Investigators coded the responses and analyzed the results using grounded theory methodology.

Results
Six hundred seventy-three participants who responded to the free-text were analyzed. The mean age of respondents was 52 years, with an average of 10 years since IC/BPS diagnosis. The IC/BPS pain syndrome diagnosis had wide ranging effects on both symptoms and coping. These effects were often mediated by improvements in perceived control and empowerment after diagnosis. Although most participants noted benefit after diagnosis of IC/BPS, some reported harmful effects ranging from stigmatization by providers to desperation when told that there was not a cure.

Conclusions
A formal medical diagnosis of IC/BPS has a significant effect on patients who experience the condition. Although diagnosis usually improves symptoms and coping, a universal experience was not described by all IC/BPS patients. Given that most patients report improvement, more work is needed to expedite diagnosis. In addition, we must better understand factors associated with lack of symptom and quality of life improvement after an IC/BPS diagnosis has been made by medical providers.
Postoperative Admission, Readmission, and Complications for Patients 60 Years and Older Who Are Undergoing an Isolated Sling Procedure for Stress Incontinence: A Database Study
Authors: Winkelman William D. , Jaresova Andrea , Modest Anna M. , Richardson Monica L. 
Published: November 2020

Objective
The aim of the study was to determine the effect of increasing age on postoperative admission, readmission, and complications for patients 60 years and older who underwent a synthetic or autologous sling procedure for stress incontinence.

Methods
A retrospective cohort study of surgical cases from 2012 to 2017 from the American College of Surgeons National Surgical Quality Improvement Program database was conducted. Eligible patients were at least 60 years old and underwent an isolated sling procedure for stress incontinence identified by Current Procedural Terminology code 57288. Baseline demographics, preoperative comorbidities, and postoperative complications were obtained. Risk ratios (RRs) and 95% confidence intervals were calculated using log-binomial regressions.

Results
Of 3,960 eligible patients, 634 (16.0%) were admitted postoperatively. Admission rates differed across age groups (P = 0.04). For example, compared with patients aged 60–64 years, those aged 70–74 years had 1.3 times the risk of admission (95% confidence interval, 1.04–1.6). Other risk factors for admission included diabetes (RR, 1.3) and hypertension (RR, 1.2). Patients who had general anesthesia had 6.3 times the risk of admission compared with those who had monitored anesthesia/intravenous sedation. There were 72 patients (1.8%) readmitted within 30 days. There was no association between age and readmission. Risk factors for readmission included diabetes (RR, 1.8), bleeding disorders (RR, 3.4), severe chronic obstructive pulmonary disease (RR, 3.7), and congestive heart failure (RR, 11.3). There were 192 complications (4.8%), including 45 major complications (1.1%).

Conclusions
Among patients 60 years and older, the risk of postoperative admission and readmission for patients undergoing a synthetic or autologous sling procedure is low and complications are uncommon.
Unanticipated Uterine and Cervical Malignancy in Women Undergoing Hysterectomy for Uterovaginal Prolapse
Authors: Andiman Sarah E. , Bui Anthony H. , Hardart Anne , Xu Xiao 
Published: November 2020

Objective
This study aimed to determine the prevalence of unanticipated uterine cancer and cervical cancer in women undergoing hysterectomy for uterovaginal prolapse.

Methods
Using data from the 2015–2018 American College of Surgeons National Surgical Quality Improvement Program, we identified adult women who underwent a hysterectomy with a concurrent procedure for uterovaginal prolapse. Patients who underwent a radical hysterectomy or had other procedures or diagnoses suggestive of preoperatively suspected or known gynecologic cancer were excluded. Our outcome measures were pathology-confirmed diagnoses of uterine cancer and cervical cancer. Bivariate statistical tests and multivariable logistic regression were used to identify patient characteristics associated with the likelihood of having unanticipated uterine cancer.

Results
Among 9,687 patients meeting the sample eligibility criteria (median age, 60 years), 51 (0.53%; 95% confidence interval, 0.39%–0.69%) had a diagnosis of uterine cancer. Forty-three (84.3%) were stage I-IB. Multivariable logistic regression showed that older age (adjusted odds ratio, 2.75; 95% confidence interval, 1.47–5.51, for age >60 vs 41–60 years) and uterine weight greater than 250 g (adjusted odds ratio, 4.34; 95% confidence interval, 1.48–10.79) were associated with a significantly higher likelihood of having unexpected uterine malignancy. In addition, in a subsample of 7,908 patients who underwent a total hysterectomy, 7 (0.09%; 95% confidence interval, 0.04%–0.18%) had a diagnosis of cervical cancer.

Conclusions
The risk of unexpected uterine cancer and cervical cancer in women undergoing hysterectomy for uterovaginal prolapse was relatively low but should be appropriately considered when counseling patients desiring uterine- or cervix-sparing procedures.
Home Biofeedback Versus Physical Therapy for Stress Urinary Incontinence: A Randomized Trial
Authors: Barnes Kara Lauren , Cichowski Sara , Komesu Yuko M. , Jeppson Peter C. , McGuire Brenna , Ninivaggio Cara S. , Dunivan Gena C. 
Published: November 2020

Objective
The aim of the study was to assess whether home biofeedback is noninferior to supervised pelvic floor physical therapy (PFPT) for the treatment of stress urinary incontinence (SUI) in women.

Methods
The study used a randomized controlled noninferiority trial to compare a home biofeedback device with PFPT. Women older than 18 years with SUI and no history of a prior incontinence surgery or PFPT were eligible. Forty-two participants were required to determine noninferiority for the primary outcome, improvement in quality of life as measured by the International Consultation on Incontinence Questionnaire Short Form. The noninferiority margin was 4 points. Secondary outcomes included sexual function, overactive bladder symptoms, and patient impression of improvement.

Results
From June 2018 to October 2019, 54 women with SUI were recruited (27 biofeedback, 27 PFPT) and 43 (21 biofeedback, 22 PFPT) completed follow-up. The groups had comparable baseline characteristics. For the primary outcome of change in mean International Consultation on Incontinence Questionnaire–Short Form scores (where lower scores indicate less incontinence), home biofeedback was found to be noninferior to PFPT with a mean decrease from baseline of −3.95 (95% confidence interval [CI] = −2.21 to −5.70) in the home biofeedback group versus −4.73 (95% CI = −3.21 to −6.25) and −3.95 (95% CI = −2.21 to −5.70) in the PFPT group (P = 0.009). The PFPT group showed more improvement in overactive bladder symptoms, but not in incontinence severity without difference in sexual function.

Conclusions
Home biofeedback was noninferior to PFPT for the primary treatment of SUI in women at 3 months. These results support the use of personal biofeedback devices for the treatment of SUI.
Clinical Trial Registration: ClinicalTrials.gov, http://www.clinicaltrials.gov, NCT03443687.
Nasopharyngeal Panbio COVID-19 antigen performed at point-of-care has a high sensitivity in symptomatic and asymptomatic patients with higher risk for transmission and older age
Authors: Masiá Mar , Fernández-González Marta , Sánchez Manuel , Carvajal Mar , García José Alberto , Gonzalo Nieves , de la Tabla Victoria Ortiz , Agulló Vanesa , Candela Inmaculada , Guijarro Jorge , Gutiérrez José Antonio , de Gregorio Carlos , Gutiérrez Félix 
Published: November 2020

ABSTRACTBackgroundPerformance of point-of-care tests in clinical practice remains undetermined. We aimed to evaluate the performance of the nasopharyngeal Panbio COVID-19 antigen Rapid Test Device in real-life conditions in different clinical scenarios.MethodProspective study conducted in three primary care centers (PCC) and an emergency department. The antigen test was performed at point-of-care in nasopharyngeal and nasal swabs, and in saliva. Positive and negative percent agreement (PPA, NPA) were calculated with the RT-PCR assay as reference standard.ResultsOf 913 patients included, 296 (32.3%) were asymptomatic and 690 (75.6%) came from the PCC. Nasopharyngeal swabs were collected from 913, nasal swabs from 659, and saliva from 611 patients. RT-PCR was positive in 196 (21.5%) nasopharyngeal samples (NPS). Overall PPA (95% CI) in NPS was 60.5% (53.3-67.4), and it was lower in nasal swabs (44.7%) and saliva (23.1%). Test performance in NPS was largely dependent on the cycle threshold (Ct) in RT-PCR, with PPA>90% for Ct≤25 and ≥80% for Ct<30. In symptomatic patients, the PPA was 95% for Ct≤25; ≥85% for Ct<30, and 89% for the symptom triad of fever, cough and malaise. Performance was also dependent on age, with PPA of 100% in symptomatic patients >50 years with Ct<25. In asymptomatic patients, the PPA was 86% for Ct<25. In all cases, NPA was 100%.ConclusionThe nasopharyngeal Panbio COVID-19 antigen test performed at point-of-care is highly sensitive in symptomatic patients, particularly with Ct<30 and older age. The test was useful to identify asymptomatic patients with lower Ct values and therefore with contagious risk.Key pointsThe nasopharyngeal Panbio-COVID-19 antigen test performed in real-life conditions at point-of-care is highly sensitive in symptomatic patients, particularly with Ct<30 and older age. The test is useful to identify asymptomatic patients with lower Ct values and therefore with contagious risk.
Lossless Distributed Linear Mixed Model with Application to Integration of Heterogeneous Healthcare Data
Authors: Luo Chongliang , Islam Md. Nazmul , Sheils Natalie E. , Reps Jenna , Buresh John , Duan Rui , Tong Jiayi , Edmondson Mackenzie , Schumie Martijn J. , Chen Yong 
Published: November 2020

AbstractLinear mixed models (LMMs) are commonly used in many areas including epidemiology for analyzing multi-site data with heterogeneous site-specific random effects. However, due to the regulation of protecting patients’ privacy, sensitive individual patient data (IPD) are usually not allowed to be shared across sites. In this paper we propose a novel algorithm for distributed linear mixed models (DLMMs). Our proposed DLMM algorithm can achieve exactly the same results as if we had pooled IPD from all sites, hence the lossless property. The DLMM algorithm requires each site to contribute some aggregated data (AD) in only one iteration. We apply the proposed DLMM algorithm to analyze the association of length of stay of COVID-19 hospitalization with demographic and clinical characteristics using the administrative claims database from the UnitedHealth Group Clinical Research Database.
Simple Accurate Regression-Based Forecasting of Intensive Care Unit Admissions due to COVID-19 in Ontario, Canada
Authors: Fisman David N. , Tuite Ashleigh R. 
Published: November 2020

AbstractThe pandemic caused by SARS-CoV-2 has proven challenging clinically, and at the population level, due to heterogeneity in both transmissibility and severity. Recent case incidence in Ontario, Canada (autumn 2020) has outstripped incidence in seen during the first (spring) pandemic wave; but has been associated with a lower incidence of intensive care unit (ICU) admissions and deaths. We hypothesized that differential ICU burden might be explained by increased testing volumes, as well as the shift in mean case age from older to younger. We constructed a negative binomial regression model using only three covariates, at a 2-week lag: log10(weekly cases); log10(weekly deaths); and mean weekly case age. This model reproduced observed ICU admission volumes, and demonstrated good preliminary predictive validity. Furthermore, when admissions were used in combination with ICU length of stay, our modeled estimates demonstrated excellent convergent validity with ICU occupancy data reported by the Canadian Institute for Health Information. Our approach needs external validation in other settings and at larger and smaller geographic scales, but appears to be a useful short-term forecasting tool for ICU resource demand; we also demonstrate that the virulence of SARS-CoV-2 infection has not meaningfully changed in Ontario between the first and second waves, but the demographics of those infected, and the fraction of cases identified, have.
Clinical Profile of First 1000 COVID-19 Cases Admitted at Tertiary Care Hospitals and the Correlates of their Mortality: An Indian Experience
Authors: Budhiraja Sandeep , Soni Aakriti , Jha Vinitaa , Indrayan Abhaya , Dewan Arun , Singh Omender , Singh Yogendra Pal , Chugh Indermohan , Arora Vijay , Pande Rajesh , Ansari Abdul , Jha Sujeet 
Published: November 2020

ABSTRACTObjectiveTo describe the clinical profile and factors leading to increased mortality in coronavirus disease (COVID-19) patients admitted to a group of hospitals in India.DesignA records-based study of the first 1000 patients with a positive result on real-time reverse transcriptase-polymerase-chain-reaction assay for SARS-CoV-2 admitted to our facilities. Various factors such as demographics, presenting symptoms, co-morbidities, ICU admission, oxygen requirement and ventilator therapy were studied.ResultsOf the 1000 patients, 24 patients were excluded due to lack of sufficient data. Of the remaining 976 in the early phase of the epidemic, males were admitted twice as much as females (67.1% and 32.9%, respectively). Mortality in this initial phase was 10.6% and slightly higher for males and steeply higher for older patients. More than 8% reported no symptoms and the most common presenting symptoms were fever (78.3%), productive cough (37.2%), and dyspnea (30.64%). More than one-half (53.6%) had no co-morbidity. The major co-morbidities were hypertension (23.7%), diabetes without (15.4%), and with complications (9.6%). The co-morbidities were associated with higher ICU admissions, greater use of ventilators as well as higher mortality. A total of 29.9% were admitted to the ICU, with a mortality rate of 32.2%. Mortality was steeply higher in those requiring ventilator support (55.4%) versus those who never required ventilation (1.4%). The total duration of hospital stay was just a day longer in patients admitted to the ICU than those who remained in wards.ConclusionMale patients above the age of 60 and with co-morbidities faced the highest rates of mortality. They should be admitted to the hospital in early stage of the disease and given aggressive treatment to help reduce the morbidity and mortality associated with COVID-19.
Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer’s disease
Authors: Dahl Martin J. , Mather Mara , Werkle-Bergner Markus , Kennedy Briana L. , Guzman Samuel , Hurth Kyle , Miller Carol A. , Qiao Yuchuan , Shi Yonggang , Chui Helena C. , Ringman John M. 
Published: November 2020

AbstractAbnormally phosphorylated tau, an indicator of Alzheimer’s disease, accumulates in the first decades of life in the locus coeruleus (LC), the brain’s main noradrenaline supply. However, technical challenges in reliable in-vivo assessments have impeded research into the role of the LC in Alzheimer’s disease.We studied participants with or known to be at-risk for mutations in genes causing autosomal-dominant Alzheimer’s disease (ADAD) of early onset, providing a unique window into the pathogenesis of Alzheimer’s largely disentangled from age-related factors. Using high- resolution MRI and tau PET, we revealed lower rostral LC integrity in symptomatic participants. LC integrity was associated with individual differences in tau burden and memory decline. Post- mortem analyses in a separate set of carriers of the same mutation confirmed substantial neuronal loss in the LC.Our findings link LC degeneration to tau burden and memory in Alzheimer’s and highlight a role of the noradrenergic system in this neurodegenerative disease.
Community Detection in a Weighted Directed Hypergraph Representation of Cell-to-cell Communication Networks
Authors: Hou Rui , Small Michael , Forrest Alistair R. R. 
Published: November 2020

AbstractCell-to-cell communication is mainly triggered by ligand-receptor activities. Through ligandreceptor pairs, cells coordinate complex processes such as development, homeostasis, and immune response. In this work, we model the ligand-receptor-mediated cell-to-cell communication network as a weighted directed hypergraph. In this mathematical model, collaborating cell types are considered as a node community while the ligand-receptor pairs connecting them are considered a hyperedge community. We first define the community structures in a weighted directed hypergraph and develop an exact community detection method to identify these communities. We then modify approximate community detection algorithms designed for simple graphs to identify the nodes and hyperedges within each community. Application to synthetic hypergraphs with known community structure confirmed that one of the proposed approximate community identification strategies, named HyperCommunity algorithm, can effectively and precisely detect embedded communities. We then applied this strategy to two organism-wide datasets and identified putative community structures. Notably the method identifies non-overlapping edge-communities mediated by different sets of ligand-receptor pairs, however node-communities can overlap.
Draft Genome Assemblies and Annotations ofAgrypnia vestitaWalker, andHesperophylax magnusBanks Reveal Substantial Repetitive Element Expansion in Tube Case-making Caddisflies (Insecta: Trichoptera)
Authors: Olsen Lindsey K. , Heckenhauer Jacqueline , Sproul John S. , Dikow Rebecca B. , Gonzalez Vanessa L. , Kweskin Matthew P. , Taylor Adam M. , Wilson Seth B. , Stewart Russell J. , Zhou Xin , Holzenthal Ralph , Pauls Steffen U. , Frandsen Paul B. 
Published: November 2020

AbstractTrichoptera (caddisflies) play an essential role in freshwater ecosystems; for instance, larvae process organic material from the water and are food for a variety of predators. Knowledge on the genomic diversity of caddisflies can facilitate comparative and phylogenetic studies thereby allowing scientists to better understand the evolutionary history of caddisflies. While Trichoptera are the most diverse aquatic insect order, they remain poorly represented in terms of genomic resources. To date, all long-read based genomes have been sequenced from individuals in the retreat-making suborder, Annulipalpia, leaving ∼275 Ma of evolution without high-quality genomic resources. Here, we report the first long-read basedde novogenome assemblies of two tube case-making Trichoptera from the suborder Integripalpia,Agrypnia vestitaWalker andHesperophylax magnusBanks. We find that these tube case-making caddisflies have genome sizes that are at least three-fold larger than those of currently sequenced annulipalpian genomes and that this pattern is at least partly driven by major expansion of repetitive elements. InH. magnus, long interspersed nuclear elements (LINEs) alone exceed the entire genome size of some annulipalpian counterparts suggesting that caddisflies have high potential as a model for understanding genome size evolution in diverse insect lineages.SignificanceThere is a lack of genomic resources for aquatic insects. So far, only three high-quality genomes have been assembled, all from individuals in the retreat-making suborder Annulipalpia. In this article, we report the first high-quality genomes of two case-making species from the suborder Integripalpia, which are essential for studying genomic diversity across this ecologically diverse insect order. Our research reveals larger genome sizes in the tube case-makers (suborder Integripalpia, infraorder Phryganides), accompanied by a disproportionate increase of repetitive DNA. This suggests that genome size is at least partly driven by a major expansion of repetitive elements. Our work shows that caddisflies have high potential as a model for understanding how genomic diversity might be linked to functional diversification and forms the basis for detailed studies on genome size evolution in caddisflies.Data depositionThis project has been deposited at NCBI under the Bioproject ID: PRJNA668166