bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Features and Efficacy of Antiviral Drug, Arbidol in 220 Nonemergency COVID‐19 Patients from East-West-Lake Shelter Hospital in Wuhan: A Retrospective Case Series
Authors: Gao Wei , Chen Si , Wang Kun , Chen Rongzhang , Guo Qian , Lu Jingjing , Wu Xiaodong , He Yanan , Yan Qiaoyun , Wang Shengyun , Wang Feilong , Jin Li , Hua Jing , Li Qiang 
Published: September 2020

Abstract
Objective. We aimed to describe the features of 220 nonemergency (mild or common type) COVID-19 patients from a shelter hospital, as well as evaluate the efficiency of antiviral drug, Arbidol in their disease progressions. Methods. Basic clinical characteristics were described and the efficacy of Arbidol was evaluated based on gender, age, maximum body temperature of the patients. Results. Basically, males had a higher risk of fever and more onset symptoms than females. Arbidol could accelerate fever recovery and viral clearance in respiratory specimens, particularly in males. Arbidol also contributed to shorter hospital stay without obvious adverse reactions.Conclusions. In the retrospective COVID-19 cohort, gender was one of the important factors affecting patient's conditions. Arbidol showed several beneficial effects in these patients, especially in males. This study brought more researches enlightenment in understanding the emerging infectious disease.
Size measurements of hepatocellular carcinoma: comparisons between contrast and two-dimensional ultrasound
Authors: Chen Fei , Wang Fei , Sun Si , Zhu Mei , Liu Zheng 
Published: September 2020

Abstract
Background

Ultrasound (US) imaging is known to underestimate tumor size in clinical. This study is aimed to compare the size measurements of hepatocellular carcinoma (HCC) in three US imaging modalities, i.e. two-dimensional (2D) imaging, the arterial phase (AP) and the late phase (LP) imaging of contrast-enhanced US (CEUS).

Methods

Fifty-eight clinically proved HCC patients were included. The 2D and CEUS imaging were performed with Siemens S2000, Philips iu22 and BioSound Twice. 2.5 mL of SonoVue® was injected for every CEUS performance. Two physicians measured the maximal longitudinal and the transverse diameters of the tumors in 2D, the AP and the LP of CEUS from one image section. The three measurements were compared by paired t test.

Results

The mean longitudinal diameter of HCC appeared to be maximal in the AP (4.73±2.04 cm) of CEUS and minimal in the LP (3.98±1.99 cm) of CEUS. The 2D diameter (4.26±2.07 cm) was in the middle between two CEUS measurements. There were significant differences between any two measurements.

Conclusion

There is size difference between the three kinds of HCC measurement. It appeared to be maximal in the AP of CEUS and minimal in the LP. The 2D diameter was in the middle.
A case of long-term survival after splenectomy for solitary splenic metastasis from gastric cancer
Authors: Obana Ayato , Komatsu Nobuo , Aiba Kazuma , Nakanishi Shinya , Abe Masakazu , Yamaguchi Toshiyuki , Hayashi Masahiro , Obi Hayato , Koyama Masamichi , Hashimoto Shinichi 
Published: September 2020

Abstract
Background: Very rarely does a splenic solitary metastasis arise from a gastric carcinoma because splenic metastasis is usually seen in association with widespread visceral metastasis. Splenectomy is considered to be a curative treatment; however, long-term prognosis after splenectomy has scarcely been reported. We report a case of a metachronous and solitary metastasis to the spleen from gastric cancer in which the patient achieved 5-year recurrence-free survival after splenectomy.Case Presentation: An 84-year-old man underwent an open total gastrectomy involving D1+ lymph nodes dissection for gastric cancer located in the cardia (pT3N1M0, pStage IIB). Eighteen months later, a 2-cm solitary hypodense lesion was detected in the spleen by computed tomography (CT). Twenty-three months later, the serum carcinoembryonic antigen (CEA) value elevated to 19.9 ng/ml, and abdominal CT revealed an increase in tumor size to 5 cm. Positron-emission tomography (PET)-CT revealed intense 18F-2-deoxy-2-fluoro-glucose (FDG) uptake in the spleen without the involvement of other organs and lymph nodes. We diagnosed him with solitary splenic metastasis from gastric cancer and performed a splenectomy 26 months after the first surgery. Histological examination revealed that the splenic tumor was a moderately differentiated adenocarcinoma, which was very similar to the primary gastric tumor; the lesion was diagnosed as a metastatic tumor from the previous gastric carcinoma. The patient remains healthy to date without recurrence, 5 years after the splenectomy. Conclusion: We experienced a case of a solitary splenic metastasis from gastric cancer in which 5-year recurrence-free survival was achieved after splenectomy. To determine the surgical indication in patients with splenic metastasis, it is important to differentiate between a solitary lesion or multiple metastasis. Especially, occult metastasis should be excluded by means of several months of follow-up with imaging tests and systemic FDG-PET surveys before splenectomy.
Nomogram to predict overall survival for patients with pseudomyxoma peritonei of appendiceal origin: A retrospective cohort study
Authors: Bai Mingjian , Wang Shilong , Ma Ruiqing , Cai Ying , Lu Yiyan , Hou Nianzong , Liang Guowei , Xu Hongbin , Zhang Man 
Published: September 2020

Abstract
Background Pseudomyxoma peritonei (PMP) is a rare disease, the prognosis of overall survival (OS) is affected by many factors, present study aim to define independent prediction indicators and establish a nomogram for PMP patients.Methods 119 PMP patients received cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) in our center for the first time were included between 01/06/2013 and 22/11/2019 . The log-rank test was used to compare the OS rate among groups, subsequently, variables with P<0.10 were subjected to multivariate Cox model for defining independent prediction indicators. Finally, the nomogram prediction models will be established and for internal validation.Results Multivariate analysis showed Sex, D-Dimer, CA125, CA19-9, PCI, and degree of radical surgery were independently associated with OS in PMP patients. A nomogram was plotted based on the independent predictive factors and undergone internal validation, ROC analysis was performed to calculate discrimination ability of the nomogram, the C-index was 0.880 (95%CI: 0.806- 0.933) and calibration plots showed good performance. Conclusions Six independent prognostic factor for predicting survival in PMP patients were difined, the nomogram has a good discrimination ability for individual risk predition, more researches are needed to verify and improve the prediction model.
Medical status of patients presenting for treatment at an Australian dental institute: A cross-sectional study
Authors: Frydrych Agnieszka Monika , Parsons Richard , Kujan Omar 
Published: September 2020

Abstract
Background: Individuals seeking dental treatment often present with medical conditions which may affect dental treatment provision. The purpose of this study was to determine the prevalence of medical conditions and medication use among individuals attending dental clinics at a Western Australian tertiary institution.Methods: This observational study examined the general demographics, medical and social histories of 873 subjects presenting for a general dental examination at a Western Australian Tertiary Institution between March 2018 and February 2019. Individual recruited were those presenting to the clinics either as new patients to the Centre or returning patients after an extended period of absence.Results: Presence of a medical condition was reported by 86% of the participants, with males more commonly affected (p=0.0448). Medication use was noted by 80% of the participants. Cardiovascular disease (37.9%), allergy (32.3%), mental health disorders (29.4%), musculoskeletal (23.0%), endocrine (22.4%) and respiratory disease (17.8%) were the most common conditions identified. Women were significantly more likely to report allergy (p=0.0002) or a mental health condition (p=0.0368). Conclusions: Medical comorbidities are common among individuals presenting for student dental treatment in Western Australia, highlighting the importance of knowledge and teaching of internal medicine and its application to the dental setting.
Are Clinical Practice Guidelines for Low Back Pain interventions of high quality and updated? A systematic review using the AGREE II instrument
Authors: Castellini Greta , Iannicelli Valerio , Briguglio Matteo , Corbetta Davide , Sconfienza Luca Maria , Banfi Giuseppe , Gianola Silvia 
Published: September 2020

Abstract
BACKGROUND: Clinical practice guidelines (CPGs) provide recommendations for practice, but the proliferation of CPGs issued by multiple organisations in recent years has raised concern about their quality. The aim of this study was to systematically appraise CPGs quality for low back pain (LBP) interventions and to explore inter-rater reliability (IRR) between quality appraisers. The time between systematic review search and publication of CPGs was recorded.METHODS: Electronic databases (PubMed, Embase, PEDro, TRIP), guideline organisation databases, websites, and grey literature were searched from January 2016 to January 2020 to identify GPCs on rehabilitative, pharmacological or surgical intervention for LBP management. Four independent reviewers used the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool to evaluate CPGs quality and record the year the CPGs were published and the year the search strategies were conducted. RESULTS: A total of 21 CPGs met the inclusion criteria and were appraised. Seven (33%) were broad in scope and involved surgery, rehabilitation or pharmacological intervention. The score for each AGREE II item was: Editorial Independence (median 67%, interquartile range [IQR] 31 – 84%), Scope and Purpose (median 64%, IQR 22 – 83%), Rigour of Development (median 50%, IQR 21 – 72%), Clarity and Presentation (median 50%, IQR 28 – 79%), Stakeholder Involvement (median 36%, IQR 10 – 74%), and Applicability (median 11%, IQR 0 – 46%). The IRR between the assessors was nearly perfect (interclass correlation 0.90; 95% confidence interval 0.88 – 0.91). The median time span was 2 years (range, 1-4), however, 38% of the CPGs did not report the coverage dates for systematic searches.CONCLUSIONS: We found methodological limitations that affect CPGs quality. A universal database is needed in which guidelines can be registered and recommendations dynamically developed through a living systematic reviews approach to ensure that guidelines are based on updated evidence. LEVEL OF EVIDENCE: 1REGISTRATION PROSPERO DETAILS: CRD42019127619.
Detection of Carbapenemase-producing Klebsiella pneumoniae isolated from Environmental Sources in a Tertiary Health Institution in Nigeria.
Authors: Aghanya Iloduba Nnaemeka , Akujobi Comfort Nne , Ushie Simon Nkpeh , Ubajaka Chika Florence , Ajuba Ijeoma Maryrose , Ezeama Chibuike Jesse , Maduekwe Nkechi Perpetua , Uzoewulu Ngozichukwu Gertrude , Chigbo Chisom Godswill 
Published: September 2020

Abstract
Objective The acquisition of carbapenemase-producing organisms in healthcare settings is a major threat and has serious implications for public health. Previous reports regarding carbapenemase-producing Enterobacteriaceae from fomites are limited. This study aimed at analysing the antimicrobial resistance patterns, and prevalence of carbapenemase-producing Klebsiella pneumoniae in the ward environments of a tertiary health institution in Nigeria. Results A total of 142 bacteria were isolated from 534 fomites in the hospital wards, and of the 142 isolates, 15(10.6%) were confirmed to be Klebsiella pneumoniae . The prevalence of Klebsiella pneumoniae in all the 534 samples was 15/534(2.8%), while the prevalence of carbapenemase-producing Klebsiella pneumoniae was 8/534(1.5%). Multi-drug resistance was detected in 15/15(100%) of the Klebsiella pneumoniae isolated. Although no Klebsiella pneumoniae Carbapenemase ( bla KPC ) gene was expressed in any of these isolates, 8/15(53.3%) of these isolates were confirmed positive for carbapenemase production using the Modified Hodge Test. The commonest sites that harboured carbapenem-resistant Klebsiella pneumoniae were the beds 6/15(40%). Maximum resistance (100%) was observed against ampicillin, trimethoprim-sulfamethoxazole, cefuroxime, and tetracycline. In conclusion, the prevalence of carbapenemase-producing Klebsiella pneumoniae fomite colonization in the NAUTH ward environment is low, thus buttressing the need to reinforce strict infection control policies the hospital.
Extended thymectomy with blood vessel resection and reconstruction improves therapeutic outcome for clinical stage III thymic carcinoma patients: a real-world research
Authors: Liu Lei , Zhang Jiaqi , Wang Guige , Guo Chao , Chen Yeye , Huang Cheng , Li Shanqing 
Published: September 2020

Abstract
Objectives We examine the therapeutic efficacy of extended thymectomy with blood vessel resection and reconstruction in thymic carcinoma patients with great vessel invasion. Methods In total 26 patients diagnosed as clinical stage III thymic carcinoma with severe great vessel invasion were enrolled in this retrospective study. Among these patients, 14 cases received adjuvant chemo- and radiotherapy (non-operation subgroup, NOG), the other 12 patients received extended thymectomy with vessel resection and reconstruction followed by the adjuvant treatment (operation subgroup, OG). Results All surgical procedures went smoothly with no perioperative death. R0 resection was obtained in all surgical cases, and we also observed a lymph node metastasis rate of 38.8%. The overall survival (OS) was 34 months for the whole cohort, 48 and 26 months for the OG and NOG respectively (p=0.013). The median disease metastasis free survival (DMFS) was 47 months for the OG and 18 months for the NOG (p=0.019). Conclusion Extended thymectomy with vessel resection is feasible for patients with clinical stage III thymic carcinoma. Surgery significantly improves the overall survival and the prognosis of clinical stage III thymic carcinoma.
Antimicrobial Resistance of Escherichia coli and Salmonella isolated from Raw Retail Broiler Chicken Carcasses in Zambia
Authors: Muonga Elizabeth Muligisa , Mainda Geoffrey , Mukuma Mercy , Kwenda Geoffrey , Hang'ombe Bernard , Bumbangi Flavien , Phiri Nelson , Mwansa Mwaba , Munyeme Musso , Muma John Bwalya 
Published: September 2020

Abstract
Background Antimicrobial resistance (AMR) of foodborne pathogens is of public health concern, especially in developing countries such as Zambia. This study was undertaken to determine the antimicrobial resistance profiles of Escherichia coli (E. coli) and Salmonella isolated from raw retail broiler chicken carcasses purchased from open and supermarkets in Zambia.Results A total of 189 E. coli and five Salmonella isolates were isolated. Identification and confirmation of the isolates were done using Analytical Profile Index (API 20E) (Biomerieux®) and 16S rRNA sequencing. Antimicrobial susceptibility tests (AST) were performed using the Kirby Bauer disk diffusion technique using a panel of 10 antibiotics. Multiplex PCR was used to determine the presence of three target genes encoding for resistance: tetA, Sul1 and blaCTX-M. WHONET 2018 software was used to analyse AST results. The E. coli isolates were mostly resistant to tetracycline (79.4%), ampicillin (51.9%), and trimethoprim/sulfamethoxazole (49.7%). Two of the five Salmonella isolates were resistant to at least one antibiotic. Forty- seven (45.2%) of the 104 isolates that were screened for the presence of the resistant genes possessed at least one of the targeted resistance genes.Conclusion This study has demonstrated the presence of AMR E. coli and Salmonella on raw retail broiler chicken carcasses from open and supermarkets, which is of public health concern.
Artificial Intelligence and Machine Learning in Orthopedic Surgery: A Systematic Review Protocol
Authors: Maffulli Nicola , Rodriguez Hugo C. , Stone Ian W. , Nam Andrew , Song Albert , Gupta Manu , Alvarado Rebecca , Ramon David , Gupta Ashim 
Published: September 2020

Abstract
Background: Artificial Intelligence (AI) and Machine Learning (ML) is interwoven into our everyday lives and has grown enormously in some major fields in medicine including cardiology and radiology. While these specialties have quickly embraced AI and ML, orthopedic surgery has been slower to do so. Fortunately, there has been a recent surge in new research emphasizing the need for a systematic review. The primary objective of this systematic review will be to provide an update on the advances of AI and ML in the field of orthopedic surgery. The secondary objectives will be to evaluate the applications of AI and ML in providing a clinical diagnosis and predicting post-operative outcomes and complications in orthopedic surgery.Methods: A systematic search will be conducted in PubMed, ScienceDirect, and Google Scholar databases for articles written in English, Italian, French, Spanish and Portuguese language articles published up to September 2020. References will be screened and assessed for eligibility by at least two independent reviewers as per PRISMA guidelines. Studies must apply to orthopedic interventions, acute and chronic orthopedic musculoskeletal injuries to be considered eligible. Studies will be excluded if they are animal studies, do not relate to orthopedic interventions, or if no clinical data were produced. Gold standard processes and practices to obtain a clinical diagnosis and predict post-operative outcomes shall be compared with and without the use of ML algorithms. Any case reports and other primary studies assessing the prediction rate of post-operative outcomes or the ability to identify a diagnosis in orthopedic surgery will be included. Systematic reviews or literature reviews will be examined to identify further studies for inclusion, and results of meta-analyses will not be included in the analysis.Discussion: Our findings will evaluate the advances of AI and ML in the field of orthopedic surgery. We expect to find a large quantity of uncontrolled studies, and a smaller subset of articles describing actual applications and outcomes for clinical care. Cohort studies and large randomized control trial will likely be needed.Trial registration: The Protocol will be registered on PROSPERO international prospective register of systematic reviews prior to commencement.
Clinical Value of Patlak Ki Images Extracted From Dynamic 18F-FDG PET/CT For Evaluation of The Relationships Between Disease Activity and Clinical Events in Cardiac Sarcoidosis
Authors: Nakajo Masatoyo , Ojima Satoko , Kawakami Hirofumi , Tani Atsushi , Hirayama Akira , Jinguji Megumi , Kubozono Takuro , Ohishi Mitsuru , Yoshiura Takashi 
Published: September 2020

Abstract
The authors have withdrawn this preprint due to erroneous posting.
Diagnostic value of bronchoalveolar lavage fluid cryptococcal antigen-lateral flow immunochromatographic assay for pulmonary cryptococcosis in non-HIV patients
Authors: Zeng Hui-Qing , Cai Xue-Ying , Zhang Xiao-Bin , Yang Dong-Yong , Lin Li , Chen Mei-Jun , Guo Wei-Feng , Luo Xiongbiao 
Published: September 2020

Abstract
Background: Early diagnosis of pulmonary cryptococcosis (PC) without human immunodeficiency virus (HIV) infection may be challenging. The aim of this study was to investigate the diagnostic value of cryptococcal antigen-lateral flow immunochromatographic assay (CrAg-LFA) in bronchoalveolar lavage fluid (BALF) of patients with PC. Methods: A total pf 308 patients who were admitted to the departments of pulmonary and critical care medicine and thoracic surgery between March 2015 and October 2018, were divided into the PC group (n=72) and the non-PC group (n=236). PC was confirmed by 1) lung biopsy; 2) a positive culture of Cryptococcus neoformans (C. neoformans) from blood culture or biopsy specimen; 3) clinical data, pathogen detection, radiological imaging and the detection of the cryptococcal antigen in blood and BALF samples.Results: The sensitivity, specificity, positive and negative predicted values of CrAg-LFA in the serum were 75.0%, 99.6%, 98.2%, and 92.9%, respectively, while those in the BALF were 93.1%, 100.0%, 100.0%, and 97.9%, respectively. The sensitivity of the CrAg-LFA in BALF was significantly higher than that in the serum of the patients in the PC group (P<0.05). Conclusion: CrAg-LFA is a rapid, simple, and safe experimental method. CrAg-LFA has a higher diagnostic value for PC when analyzing BALF samples compared to serum samples. Furthermore, the BALF positive results are equivalent to the microbiological culture-positive results in terms of diagnostic value.
How breast cancer treatments affect the Quality of Life of women with non-metastatic breast cancer one year after surgical treatment: A cross-sectional study in Greece.
Authors: Yfantis Aris , Sarafis Pavlos , Moisoglou Ioannis , Tolia Maria , Intas George , Tiniakou Ioanna , Zografos Konstantinos , Zografos George , Constantinou Marianna , Nikolentzos Athanasios , Kontos Michalis 
Published: September 2020

Abstract
Background: The continuously increasing survivorship of female breast cancer makes the monitoring and improvement of patients’ quality of life ever so important. While globally there is a growing body of research on health-related quality of life one year after surgical treatment for non-metastatic breast cancer, up-to-date information regarding Greek patients is scarce.Objective: To measure the level of QoL of non-metastatic BC survivors in Greece 1 year after surgery.Methods: A sample of 200 female breast cancer survivors aged 18 to 75, who followed up as outpatients in five public hospitals were included in this cross-sectional study. All recruited patients agreed to participate in the study (100% response rate). Quality of life data were collected through the EORTC QLQ-C30 as well as BR23 questionnaires.Results: Cronbach’s alpha for all scales of the two questionnaires was from 0.551 to 0.936 indicating very good reliability. According to the Multiple Linear Regression, older patients showed a lower future perspective (p= .031), with those living in rural areas, which was associated with more financial difficulties (p= .001). Women with tertiary education and those who had been hospitalized in a university hospital recorded better on global health status (p= .003 and .000 respectively). Patients who underwent chemotherapy reported better scores in the emotional function sub-scale (p= .025). Women with reconstruction and at least one complication appeared to have significantly better scores in future perspective and social function (p= .005, .002 respectively).Conclusions: Breast cancer survivors were found to have an overall good quality of life, functioning/symptoms scores and were satisfied with the provided care.