bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immune biomarkers in thymic epithelial tumors: expression patterns, prognostic value and comparison of diagnostic tests for PD-L1
Authors: Rouquette Isabelle , Taranchon-Clermont Estelle , Gilhodes Julia , Bluthgen Maria-Virginia , Perallon Romain , Chalabreysse Lara , De Muret Anne , Hofman Veronique , Marx Alexander , Parrens Marie , Secq Veronique , Thomas de Montpreville Vincent , Galateau-Salle Françoise , Brousset Pierre , Milia Julie , Girard Nicolas , Besse Benjamin , Molina Thierry Jo , Mazières Julien 
Published: December 2019

Abstract
Background
Immunotherapy is currently under investigation in B3 Thymoma (TB3) and Thymic Carcinoma (TC). PD-L1 expression has been evaluated on a limited number of patients with selected antibodies. We aimed to analyze cohort of TB3 and TC with a panel of antibodies to assess the prevalence of PD-L1 expression, its prognostic value and to set up a reproducible test.

Methods
We retrospectively studied 103 patients samples of FFPE histologically confirmed TB3 (n = 53) and TC (n = 50) by expert pathologists within the RYTHMIC national network. We compared PD-L1, PD1, CD8 and PD-L2 expression and performed correlation with tumor types and patients outcomes. Four PD-L1 antibodies were tested, three of them validated as companion tests in lung cancer, one tested on two automates on whole section of tumors. We evaluated the percentage and intensity of both epithelial and immune stained cells.

Results
TB3 epithelial cells had a higher and more diffuse expression of PD-L1 than TC regardless the antibodies tested (p < 0.0001). Three out of four antibodies targeting PD-L1 tested on the DAKO autostainer gave similar staining. Concordance between antibodies was lower for PD-L1 staining on immune cells with no significant difference between TB3 and TC except on E1L3N antibody. PD-L2 antibody stained no tumor epithelial cells. High PD-L1 expression was correlated with a better overall survival for TB3 and was not correlated with tumor staging.

Conclusion
Frequent PD-L1 expression, particularly in TB3, paves the way for immunotherapy in TET (Thymic Epithelial Tumor). Otherwise, we have set up three reproducible LDT (laboratory-developed test) for four PD-L1 antibodies.
Analysing gamification elements in educational environments using an existing Gamification taxonomy
Authors: Toda Armando M. , Klock Ana C. T. , Oliveira Wilk , Palomino Paula T. , Rodrigues Luiz , Shi Lei , Bittencourt Ig , Gasparini Isabela , Isotani Seiji , Cristea Alexandra I. 
Published: December 2019

AbstractGamification has been widely employed in the educational domain over the past eight years when the term became a trend. However, the literature states that gamification still lacks formal definitions to support the design and analysis of gamified strategies. This paper analysed the game elements employed in gamified learning environments through a previously proposed and evaluated taxonomy while detailing and expanding this taxonomy. In the current paper, we describe our taxonomy in-depth as well as expand it. Our new structured results demonstrate an extension of the proposed taxonomy which results from this process, is divided into five dimensions, related to the learner and the learning environment. Our main contribution is the detailed taxonomy that can be used to design and evaluate gamification design in learning environments.
Moderately prolonged permissive hypotension results in reversible metabolic perturbation evaluated by intracerebral microdialysis - an experimental animal study
Authors: Jakobsen Rasmus Peter , Nielsen Troels Halfeld , Mølstrøm Simon , Nordström Carl-Henrik , Granfeldt Asger , Toft Palle 
Published: December 2019

Abstract
Background
Damage control resuscitation (DCR) and damage control surgery (DCS) is the main strategy in patients with uncontrollable hemorrhagic shock. One aspect of DCR is permissive hypotension. However, the duration of hypotension that can be tolerated without affecting the brain is unknown. In the present study we investigate the effect of 60 min severe hypotension on the brain’s energy metabolism and seek to verify earlier findings that venous cerebral blood can be used as a marker of global cerebral energy state.

Material and methods
Ten pigs were anaesthetized, and vital parameters recorded. Microdialysis catheters were placed in the left parietal lobe, femoral artery, and superior sagittal sinus for analysis of lactate, pyruvate, glucose, glycerol, and glutamate. Hemorrhagic shock was induced by bleeding the animal until mean arterial pressure (MAP) of 40 mmHg was achieved. After 60 min the pigs were resuscitated with autologous blood and observed for 3 h.

Results
At baseline the lactate to pyruvate ratios (LP ratio) in the hemisphere, artery, and sagittal sinus were (median (interquartile range)) 13 (8–16), 21 (18–24), and 9 (6–22), respectively. After induction of hemorrhagic shock, the LP ratio from the left hemisphere in 9 pigs increased to levels indicating a reversible perturbation of cerebral energy metabolism 19 (12–30). The same pattern was seen in LP measurements from the femoral artery 28 (20–35) and sagittal sinus 22 (19–26). At the end of the experiment hemisphere, artery and sinus LP ratios were 16 (10–23), 17 (15–25), and 17 (10–27), respectively. Although hemisphere and sinus LP ratios decreased, they did not reach baseline levels (p < 0.05). In one pig hemisphere LP ratio increased to a level indicating irreversible metabolic perturbation (LP ratio > 200).

Conclusion
During 60 min of severe hypotension intracerebral microdialysis shows signs of perturbations of cerebral energy metabolism, and these changes trend towards baseline values after resuscitation. Sagittal sinus microdialysis values followed hemisphere values but were not distinguishable from systemic arterial values. Venous (jugular bulb) microdialysis might have a place in monitoring conditions where global cerebral ischemia is a risk.
Utilizing the combined antifungal potential of Trichoderma spp. and organic amendments against dry root rot of mungbean
Authors: Choudhary Anam , Ashraf Shabbir 
Published: December 2019

AbstractThe present study was carried out to evaluate the effect of bioagents and organic amendments in suppressing the dry root rot of mungbean incited by Rhizoctonia bataticola. The locally isolated pathogen and fungal biocontrol agents were identified based on morphological and molecular characterization. These identified bioagents were tested in vitro, and the highest mycelial inhibition was recorded in dual culture assay by Trichoderma harzianum (74.44%), and among organic amendments, maximum mycelial inhibition was found in neem cake (61.11%). In a greenhouse study, T. harzianum + neem cake effectively enhanced the percent germination (93.33%) and decreased the percent disease mortality (11.67%) than the other treatments. The morphological parameter like plant height (57.50 cm), dry weight (22.83 g) root nodules (51), pods/plant (58), and 100-seed weight (5.78 g) were found to be at the maximum in this combined application. Physiological pigments viz. chlorophyll (2.41 mg/g) and carotenoids (0.19 mg/g), protein content (5.85 mg/g), and leghemoglobin (11.75 mg/g) were also found to be maximum in T. harzianum + neem cake and minimum phenol content (1.41 mg/g). The study concludes that T. harzianum + neem cake can be recommended as an effective approach for the management of dry root rot of mungbean.
Isolated unilateral palatal and vocal cord palsy as an initial presentation of chronic inflammatory demyelinating polyradiculoneuropathy
Authors: Karri Madhavi , Ramasamy Balakrishnan 
Published: December 2019

Abstract
Introduction
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an acquired autoimmune disease of the peripheral nervous system. Its clinical presentation and excellent response to steroids is a hallmark to the disease entity. It is usually a straight forward diagnosis in typical cases. Atypical CIDP often is of diagnostic concern and has been a challenge for practising neurologists.

Case description
Here, we present a 56-year old female presented with isolated left palatal palsy preceded by a short febrile illness. Clinically consistent with post-infectious bulbar palsy, she was treated with intravenous pulse steroids and antibiotics. She had progressive disease and later developed quadriparesis with neck flexor weakness with progressive bulbar weakness and hypercapnic respiratory failure.

Discussion and evaluation
MRI whole spine with contrast showed nerve root enhancement. Nerve conduction studies of all four limbs and LP and CSF analysis were consistent with CIDP. She was treated with intravenous immunoglobulin (0.4 g/kg for five consecutive days). She showed mild improvement of symptoms initially and later had deterioration of symptoms within a week interval. She received two doses of Rituximab of 1 gram each within 3 weeks apart, after which she has gradual improvement. She was able to tolerate orally and able to walk without support following 1 month after treatment, and there were no further relapses except for the persistence of minor sensory symptoms after 6 months of follow-up.

Conclusion
Isolated cranial nerve involvement presenting as CIDP is a rare entity. Intravenous immunoglobulin and newer immunosuppressants like CD-20 monoclonal antibodies like rituximab have a significant role in the treatment.
Estimating topsoil texture fractions by digital soil mapping - a response to the long outdated soil map in the Philippines
Authors: Mondejar Jeremy P. , Tongco Alejandro F. 
Published: December 2019

AbstractDigital soil mapping for soil texture is mostly an understanding of how soil texture fractions vary in space as influenced by environmental variables mainly derived from the digital elevation model (DEM). In this study, topsoil texture models were generated and evaluated by multiple linear regression (MLR), ordinary kriging (OK), simple kriging (SK) and universal kriging (UK) using free and open-source R, System for Automated Geoscientific Analyses, and QGIS software. Comparing these models is the main objective of the study. The study site covers an area of 124 km2 of the Municipality of Barili, Cebu. A total of 177 soil samples were gathered and analyzed from irregular sample points. DEM derivatives and remote sensing data (Landsat 8) were used as environmental variables. Exploratory analyses revealed no outlier in the data. Skewness and kurtosis values of the untransformed data vary greatly between –3.85 to 7.20 and 1.8 to 70.7, respectively; an indication that variables are highly skewed with heavy tails. Thus, Tukey’s ladder of powers transformation was applied that resulted to normal or nearly normal distribution having skewness values close to zero and kurtosis values have lighter tails. All data analysis from MLR modeling, variography, kriging, and cross-validations of models were implemented using the transformed data. Forward selection, backward elimination, and stepwise selection methods were adapted for predictors selection in MLR. The MLR, OK, SK, and UK were applied and cross validated for topsoil texture prediction. Likewise, exponential, Gaussian, and spherical models were fitted for the experimental variograms. Backward elimination method for clay, sand, and silt have the lowest MAE and highest R2 in MLR. The UK fitted with exponential variogram model has the highest R2 of 0.878, 0.821, and 0.893 for clay, sand, and silt, respectively. These models can be adapted as a decision support for agricultural land use planning and crop suitability development in the area.
The Thin White Line: Veterans and the White Racial Politics of Creative Writing
Authors: Darda Joseph 
Published: December 2019

Abstract
This essay considers how the creative writing workshop transformed the white Vietnam vet into a minority writer. The MFA system, which organized the group-based politics of post–civil rights American literature, originated as a space geared toward white combat veterans. Some of the first graduate programs in creative writing were founded in the years after World War II, and their classes were dominated by white vets attending college on the GI Bill. The vets received the now-clichéd advice to write what they know, to turn their war experiences into war stories. The next wave of program building followed the passage of the Higher Education Act of 1965 and the Vietnam Veterans’ Readjustment Benefits Act of 1966, which brought Vietnam vets into a changing workshop, where students still learned to write what they know but also, as pre–civil rights racial liberalism turned to post–civil rights liberal multiculturalism, write who they are. The trauma of combat allowed white men to situate themselves within late twentieth-century literary culture by writing not as white men but as “veteran-Americans.” Veteran-American literature set white men within the pluralist institution but without forfeiting the cultural center, or the front seat in the classroom.
The Right to Strike and Legal War in Walter Benjamin's “Toward the Critique of Violence”
Authors: Crépon Marc , Bez Micol 
Published: December 2019

Abstract
The object of this article is to show how, at the beginning of his essay “Toward the Critique of Violence,” Walter Benjamin uses the questions of the right to strike and law of war to exemplify the way in which the state monopoly has no other goal than to preserve the law itself. In so doing, the question of the boundary between violence and nonviolence is put into conversation with the distinction made by Georges Sorel between the political strike and the general revolutionary strike.
Transitioning from measurement-based to combined patient-specific quality assurance for intensity-modulated proton therapy
Authors: Chen Mei , Yepes Pablo , Hojo Yoshifumi , Poenisch Falk , Li Yupeng , Chen Jiayi , Xu Cheng , He Xiaodong , Gunn G.Brandon , Frank Steven J. , Sahoo Narayan , Li Heng , Zhu Xiaorong Ronald , Zhang Xiaodong 
Published: December 2019

Objective:
This study is part of ongoing efforts aiming to transit from measurement-based to combined patient-specific quality assurance (PSQA) in intensity-modulated proton therapy (IMPT). A Monte Carlo (MC) dose-calculation algorithm is used to improve the independent dose calculation and to reveal the beam modeling deficiency of the analytical pencil beam (PB) algorithm.

Methods:
A set of representative clinical IMPT plans with suboptimal PSQA results were reviewed. Verification plans were recalculated using an MC algorithm developed in-house. Agreements of PB and MC calculations with measurements that quantified by the γ passing rate were compared.

Results:
The percentage of dose planes that met the clinical criteria for PSQA (&gt;90% γ passing rate using 3%/3 mm criteria) increased from 71.40% in the original PB calculation to 95.14% in the MC recalculation. For fields without beam modifiers, nearly 100% of the dose planes exceeded the 95% γ passing rate threshold using the MC algorithm. The model deficiencies of the PB algorithm were found in the proximal and distal regions of the SOBP, where MC recalculation improved the γ passing rate by 11.27% (p &lt; 0.001) and 16.80% (p &lt; 0.001), respectively.

Conclusions:
The MC algorithm substantially improved the γ passing rate for IMPT PSQA. Improved modeling of beam modifiers would enable the use of the MC algorithm for independent dose calculation, completely replacing additional depth measurements in IMPT PSQA program. For current users of the PB algorithm, further improving the long-tail modeling or using MC simulation to generate the dose correction factor is necessary.

Advances in knowledge:
We justified a change in clinical practice to achieve efficient combined PSQA in IMPT by using the MC algorithm that was experimentally validated in almost all the clinical scenarios in our center. Deficiencies in beam modeling of the current PB algorithm were identified and solutions to improve its dose-calculation accuracy were provided.
Measurement properties of the translations of instruments evaluating the subjective effects of tobacco- and nicotine-containing products: a systematic review of the literature
Authors: Acquadro Catherine , Desvignes-Gleizes Céline , Mainy Nelly , Hankins Matthew , Weitkunat Rolf , Chrea Christelle 
Published: December 2019

Background: Several instruments are widely used for assessing dependence, craving, withdrawal symptoms, and reinforcing effects in users of tobacco- and nicotine-containing products (TNP), including the Fagerström Test for Nicotine Dependence (FTND), Questionnaire of Smoking Urges, original (QSU) and brief (QSU-b) versions; Minnesota Nicotine Withdrawal Scale, original (MNWS) and revised (MNWS-R) versions; and Cigarette Evaluation Questionnaire, original (CEQ) and modified (mCEQ) versions. Although these instruments have been translated extensively, their translations and corresponding measurement properties have not been systematically assessed. This study aimed to (1) identify the translations of these instruments for which psychometric properties have been published, (2) describe the methods used for translation, and (3) describe the measurement properties and the context in which these translations were evaluated (e.g., target population and TNP used). Methods: Embase and MEDLINE databases were systematically searched. Results: While no information could be found for the CEQ/mCEQ, several translations were available for the remaining instruments: FTND, 25; QSU and QSU-b, 4 each; QSU (12-item version), 1; MNWS, 4; and MNWS-R, 1. Cigarette smokers represented the main target population in which the validation studies were conducted. Information about the translation process was reported for 25 translations. In most cases, the properties of the translations mirrored those of the originals. Differential item functioning was explored in only one case. Conclusions: There are few publications describing the measurement properties of the translations of the FTND, QSU/QSU-b, and MNWS/MNWS-R. None of these translations have been validated for TNPs other than cigarettes, which suggests the need for greater development and validation of instruments in this area.
Influence of midwife communication on women's understanding of Down syndrome screening information
Authors: John Sophie , Kirk Maggie , Tonkin Emma , Stuart-Hamilton Ian 
Published: December 2019

Aim To analyse how midwives communicate Down syndrome screening information and explore whether women's understanding of this information is influenced by midwives' communicative style. Methods Midwives (n=16) and women (n=100) were recruited from a regional NHS unit in the UK. A mixed-methods design encompassed two components; audio-recorded antenatal consultations to assess midwives' communication and quantitative surveys to assess women's understanding. Findings Midwife communication was not significantly related to women's understanding of Down syndrome screening information. However, qualitative thematic analysis revealed midwife communication was often insufficient in fully describing Down syndrome and screening. Communication was not very interactive, midwives dominated conversations and did not sufficiently check women's knowledge/understanding. Conclusions Policymakers need to consider these findings. Deficits in midwife communication in relation to established screening practice needs to be addressed through additional training ahead of full implementation of non-invasive prenatal testing into midwifery practice.
Ebola virus disease: are you up to date?
Authors: Beese Daniel , Beckett Gail 
Published: December 2019

While the risk of seeing cases of Ebola in general practice in the UK remains low, Daniel Beese and Gail Beckett explain the importance of keeping up to date with what to do in light of the recent disease outbreak in the Democratic Republic of Congo In July 2019, an outbreak of Ebola in the Democratic Republic of Congo was declared a Public Health Emergency of International Concern by the World Health Organization. During the last major outbreak, only a few patients with Ebola were cared for by the NHS, but media interest was high and public anxiety widespread. The fear of infection saw much time and effort put into developing a plethora of guidance, policies and protocols to prevent and control any potential risk of spread. As it is now 4 years since the last outbreak, it is an opportune time to review response arrangements.
Far-infrared photodetectors based on graphene/black-AsP heterostructures
Authors: Ryzhii Victor , Ryzhii Maxim , Mitin Vladimir , Shur Michael S. , Otsuji Taiichi 
Published: December 2019

We develop the device models for the far-infrared interband photodetectors (IPs) with the graphene-layer (GL) sensitive elements and the black Phosphorus (b-P) or black-Arsenic (b-As) barrier layers (BLs). These far-infrared GL/BL-based IPs (GBIPs) can operate at the photon energies

ℏ
Ω

smaller than the energy gap, Δ
G
, of the b-P or b-As or their compounds, namely, at

ℏ
Ω
≲
2

Δ
G

/

3

corresponding to the wavelength range

λ
≳
(
6
−
12
)

μ

m. The GBIP operation spectrum can be shifted to the terahertz range by increasing the bias voltage. The BLs made of the compounds b-As
x
B1−x with different x, enable the GBIPs with desirable spectral characteristics. The GL doping level substantially affects the GBIP characteristics and is important for their optimization. A remarkable feature of the GBIPs under consideration is a substantial (over an order of magnitude) lowering of the dark current due to a partial suppression of the dark-current gain accompanied by a fairly high photoconductive gain. Due to a large absorption coefficient and photoconductive gain, the GBIPs can exhibit large values of the internal responsivity and dark-current-limited detectivity exceeding those of the quantum-well and quantum-dot IPs using the intersubband transitions. The GBIPs with the b-P and b-As BLs can operate at longer radiation wavelengths than the infrared GL-based IPs comprising the BLs made of other van der Waals materials and can also compete with all kinds of the far-infrared photodetectors.
Distributed curvature sensing based on a bending loss-resistant ring-core fiber
Authors: Shen Li , Wu Hao , Zhao Can , Shen Lei , Zhang Rui , Tong Weijun , Fu Songnian , Tang Ming 
Published: December 2019

A theoretical and experimental study on curvature sensing using a Brillouin optical time-domain analyzer based on the ring-core fiber (RCF) is reported. The Brillouin gain spectrum of the RCF is investigated, and the Brillouin frequency shift (BFS) dependence on temperature and strain is calibrated. We theoretically analyze the fiber bending-induced BFS and peak Brillouin gain variation for the RCF through a numerical simulation method, and the RCF is revealed to have a high curvature sensitivity. Distributed curvature sensing is successfully demonstrated, with the bending radius ranging from 0.5 to 1.5 cm, corresponding to a BFS variation from 32.90 to 7.81 MHz. The RCF takes advantage of great bending loss resistance, and the maximum macrobending loss at the extreme bending radius of 0.5 cm is less than 0.01 dB/turn. Besides, the peak Brillouin gain of the RCF is discovered to vary significantly in response to fiber bending, which is expected to be another parameter for distributed curvature determination. The results imply that the RCF is a promising candidate for highly sensitive distributed curvature measurement, especially in sharp bending circumstances.