bluuebunny/crossref_metadata_2025_split huggingface dataset:
Malignancy in non-HIV infected patients with cryptococcal meningitis: a retrospective study
Authors: Xu Xiaofeng , Cao Liping , Wang Yijie , Liu Jia , Dong Qing , Liang Chunling , Jiang Ying , Peng Fuhua 
Published: October 2020

Abstract
Background: Cryptococcal meningitis (CM) was found to be coexist with malignancy in non-human immunodeficiency virus (HIV) infected patients. The purpose of this study was to evaluate the clinical characteristics and therapeutic outcomes of CM in non-HIV infected patients with malignancy.Methods: A total of 320 CM patients were enrolled for analysis from January 2013-May 2019. One hundred and four patients underwent positron emission computed tomography (PET-CT) examination. The demographics, clinical characteristics, microbiological, radiological, therapeutic outcomes were analyzed in CM patients with and without malignancy.Results: Twelve patients with malignancy were found, of which 7 malignancy before CM (MBC), 5 malignancy after CM (MAC). CM patients with malignancy were older than non-malignancy ones. The prognosis of MBC patients was comparable to that of non-malignancy patients, but was extremely poor in MAC patients. Four out of 5 CM patients, who was suggested diagnosis as malignancy by PET-CT, were finally confirmed.Conclusions: This study found an increase rate of solid malignancies in CM patients. Screening malignancy in older CM patients was very important because it is closely related to prognosis and might affect treatment strategy. PET-CT might be a useful tool for early malignancy screening in CM.
Monitoring HIV Testing and Pre-Exposure Prophylaxis Information Seeking By Combining Digital and Traditional Data
Authors: Johnson Derek , Nobles Alicia L. , Caputi Theodore L. , Liu Michael , Leas Eric C. , Strathdee Steffanie A. , Smith Davey M. , Ayers John W. 
Published: October 2020

Abstract
Background. Public health is increasingly turning to non-traditional digital data to inform HIV prevention and control strategies. We demonstrate a parsimonious method using both traditional survey and internet search histories to provide new insights into HIV testing and pre-exposure prophylaxis (PrEP) information seeking that can be easily extended to other settings. Method. We modeled how US internet search volumes from 2019 for HIV testing and PrEP compared against expected search volumes for HIV testing and PrEP using state HIV prevalence and socioeconomic characteristics as predictors. States with search volumes outside the upper and lower bound confidence interval were labeled as either over or under performing. State performance was evaluated by (a) Centers for Disease Control and Prevention designation as a hotspot for new HIV diagnoses (b) expanding Medicaid coverage. Results. Ten states over-performed in models assessing information seeking for HIV testing, while thirteen states under-performed. Fourteen states over-performed in models assessing internet searches for PrEP information, while 15 states under-performed. States that expanded Medicaid coverage were more likely to over perform in PrEP models than states that did not expand Medicaid coverage.Conclusion. Our study derived a method of measuring HIV and PrEP information seeking that is comparable across states. Several states exhibited information seeking for PrEP and HIV testing that deviated from model assessments. Statewide search volume for PrEP information was affected by a state’s decision to expand Medicaid coverage. Our research provides health officials with an innovative way to monitor statewide interest in PrEP and HIV testing using a metric for information-seeking that is comparable across states.
Clinical and endoscopic features of aorto-duodenal fistula resulting in definitive diagnosis: an observational study
Authors: Ichita Chikamasa , Sasaki Akiko , Sumida Chihiro , Kimura Karen , Nishino Takashi , Tasaki Junichi , Masuda Sakue , Koizumi Kazuya , Kawachi Jun , Kako Makoto 
Published: October 2020

Abstract
Background: An aorto-duodenal fistula presents with upper gastrointestinal bleeding and hematemesis. Early diagnosis is difficult, and the disease is associated with high mortality. Sometimes, a small amount of bleeding, known as herald bleed, occurs repeatedly and may be judged as upper gastrointestinal bleeding, prompting emergency upper endoscopy. Diagnostic methods and surgical treatment during herald bleeding are important for saving lives. However, most fistulas form in the horizontal duodenum, and active bleeding is rarely found in patients with herald bleeding. Moreover, an aorto-duodenal fistula is rarely diagnosed based on upper endoscopy alone. Methods: The present study examined the clinical and endoscopic characteristics of aorto-duodenal fistula in eight patients who underwent upper endoscopy before diagnosis at our hospital. It also sought to clarify how aorto-duodenal fistula can be appropriately diagnosed. Results: All patients had a history of aortic treatment, and many could not be diagnosed by computed tomography scan or upper endoscopy alone. Regarding the endoscopic findings, patients were seen to have stent/vascular prosthesis exposure, which is diagnostic of aorto-duodenal fistula as well as pulsatile lesions and massive fresh bleeding of obscure origin in the duodenum. Conclusions: If the diagnosis is unclear, clinicians may need to observe the horizontal duodenum using a fitted tip attachment or long scope. Since vital signs may fluctuate during endoscopy, a series of tests should be performed immediately. Proactive placement of marking clips in likely areas of the fistula may facilitate diagnosis via computed tomography. The present results demonstrate that proper diagnosis and prompt surgical treatment save lives in patients with aorto-duodenal fistula.
Association Between Serum Oestradiol Level on the Human Chorionic Gonadotrophin Administration Day and Neonatal Birthweight After in Vitro Fertilization-embryo Transfer: A Retrospective Study of 3659 Singleton Live Births
Authors: Liu Yu , Li Jing , Guo Yihong 
Published: October 2020

Abstract
BackgroundOestradiol, an important hormone in follicular development and endometrial receptivity, is closely related to clinical outcomes of fresh in vitro fertilization-embryo transfer (IVF-ET) cycles. A supraphysiologic E2 level is inevitable during controlled ovarian hyper-stimulation (COH), and its effect on the outcome of IVF-ET is controversial. The aim of this retrospective study is to evaluate the association between elevated serum oestradiol (E2) levels on the day of human chorionic gonadotrophin (hCG) administration and neonatal birthweight after IVF-ET cycles.MethodsThe data of 3659 infertile patients with fresh IVF-ET cycles were analysed retrospectively between August 2009 and February 2017 in First Hospital of Zhengzhou University. Patients were categorized by serum E2 levels on the day of hCG administration into six groups: group 1 (serum E2 levels≤1000 pg/mL, n=230), group 2 (serum E2 levels between 1001 and 2000 pg/mL, n=524), group 3 (serum E2 levels between 2001 and 3000 pg/mL, n=783), group 4 (serum E2 levels between 3001 and 4000 pg/mL, n = 721), group 5 (serum E2 levels between 4001 and 5000 pg/mL, n=548 ), and group 6 (serum E2 levels > 5000 pg/mL, n=852). Univariate linear regression was used to evaluate the independent correlation between each factor and outcome index. Multiple logistic regression was used to adjust for confounding factors.ResultsThe LBW rates were as follows: 3.0% (group 1), 2.9% (group 2), 1.9% (group 3), 2.9% (group 4), and 2.0% (group 6) (P =0.629), respectively. There were no statistically significant differences in the incidences of neonatal LBW among the six groups. We did not detect an association between peak serum E2 level during ovarian stimulation and neonatal birthweight after IVF-ET.ConclusionThe results of this retrospective cohort study showed that serum E2 peak levels during ovarian stimulation were not associated with birth weight during IVF cycles. In addition, no association was found between higher E2 levels and increased LBW risk. Our observations suggest that the hyper-oestrogenic milieu during COS does not seem to have adverse effects on the birthweight of offspring after IVF.
Cumulative Live Birth Rates in Patients with Polycystic Ovary Syndrome: Comparing Progestin Primed Ovarian Stimulation Protocol and GnRH-Antagonist Protocol
Authors: Ji Jingjuan , Luo Lihua , Huang Lingli 
Published: October 2020

Abstract
Background: Cumulative live birth rate (CLBR) becomes a comprehensive and meaningful indictor of the success of IVF nowadays. Frozen-embryo transfer (FET) was associated with a higher rate of live birth and a lower risk of the ovarian hyperstimulation syndrome (OHSS) in polycystic ovary syndrome (PCOS) patients. Progestin-primed ovarian stimulation (PPOS) is a new ovarian stimulation protocol in which oral progestin been used to prevent premature luteinizing hormone (LH) surges during ovarian stimulation. The purpose of the current study is to investigate the CLBR of an in vitro fertilization (IVF) cycle in women with PCOS following PPOS protocol compared with gonadotropin releasing hormone (GnRH) antagonist protocol.Methods: It is a retrospective study. The first IVF cycle of 666 PCOS women were included. Ovarian stimulations were performed with PPOS or GnRH antagonist protocol. All patients included in the analysis had either delivered a baby or had used all their embryos of their first stimulated cycle. The patients were followed for 2–7 years until February 2020.Result(s): The CLBR were similar in the PPOS and GnRH antagonist group (64% vs 60.1%, P = 0.748). Logistic regression analyses showed treatment protocol (PPOS vs GnRH antagonist) did not show any significant correlation with the CLBR (adjusted OR: 0.898; 95% CI: 0.583-1.384, P=0.627). No statistically significant differences were found in the live birth rates per embryo transfer (41.3% vs. 38.4%) in the study group and controls.Conclusion(s): The results of this study showed that both the live birth rate per embryo transfer and the cumulative live birth rate were similar between PPOS and GnRH antagonist group. PPOS protocol is efficient in the controlled ovarian stimulation of patients with PCOS.
Assessing the Clinical Utility of Genetic Risk Scores for Targeted Cancer Screening
Authors: Conran Carly Ann , Shi Zhuqing , Resurreccion William Kyle , Na Rong , Helfand Brian T. , Genova Elena , Zheng Siqun Lilly , Brendler Charles B. , Xu Jianfeng 
Published: October 2020

Abstract
Background: Genome-wide association studies have identified thousands of disease-associated single nucleotide polymorphisms (SNPs). A subset of these SNPs may be additively combined to generate genetic risk scores (GRSs) that confer risk for a specific disease. Although the clinical validity of GRSs to predict risk of specific diseases has been well established, there is still a great need to determine their clinical utility by applying GRSs in primary care for cancer risk assessment and targeted intervention.Methods: This clinical study involved 281 primary care patients without a personal history of breast, prostate or colorectal cancer who were 40-70 years old. DNA was obtained from a pre-existing biobank at NorthShore University HealthSystem. GRSs for colorectal cancer and breast or prostate cancer were calculated and shared with participants through their primary care provider. Additional data was gathered using questionnaires as well as electronic medical record information. A t-test or Chi-square test was applied for comparison of demographic and key clinical variables among different groups.Results: The median age of the 281 participants was 58 years and the majority were female (66.6%). One hundred one (36.9%) participants received 2 low risk scores, 99 (35.2%) received 1 low risk and 1 average risk score, 37 (13.2%) received 1 low risk and 1 high risk score, 23 (8.2%) received 2 average risk scores, 21 (7.5%) received 1 average risk and 1 high risk score, and no one received 2 high risk scores. Before receiving GRSs, younger patients and women reported significantly more worry about risk of developing cancer. After receiving GRSs, those who received at least one high GRS reported significantly more worry about developing cancer. There were no significant differences found between gender, age, or GRS with regards to participants’ reported optimism about their future health neither before nor after receiving GRS results.Conclusions: Genetic risk scores that quantify an individual’s risk of developing breast, prostate and colorectal cancers as compared with a race-defined population average risk have potential clinical utility as a tool for risk stratification and to guide cancer screening in a primary care setting.
Building a Rapid Autopsy Program – A Step-by-Step Logistics Guide
Authors: Bacon Eliza R , Ihle Kena , Lee Peter P , Waisman James R 
Published: October 2020

Abstract
Background: Rapid Autopsy Programs offer an opportunity to collect tissue from patients immediately after death, providing critical biological material necessary to develop more effective therapies and improve patient outcomes. Here, we present a step-by-step guide to build a cancer-focused Rapid Autopsy Program, based on our own experiences building “The Legacy Project” at the City of Hope Comprehensive Cancer Center. Methods: The linear timeline of events is separated into four phases: 1) Building the Infrastructure, 2) Recruiting and Consenting, 3) Preparing for Death, and 4) Tissue Collection and Follow up. Important considerations and methods for adaptation are discussed throughout the protocol. Discussion: Using these methods, we successfully collected a total of 533 specimens from 9 subjects. The average time from death to last specimen acquisition was 6.1 hours (range: 4.03 – 7.66 hours; median: 5.71 hours). A diverse team with various areas of expertise is critical for successful program implementation. Our goal herein this protocol is to provide a comprehensive framework and foundation for other institutions to use as a model.
Prevalence of Goiter and Associated Factors among Women of Reproductive Age Group in Demba Goffa Woreda, Gamo Goffa Zone, Southwest Ethiopia: A Community-based Cross-sectional Study
Authors: Zekarias Befikaduwa , Mesfin Frehiwot , Mengiste Bezatu , Tesfaye Adane , Getacher Lemma 
Published: October 2020

Abstract
Background: Iodine deficiency disorder is a major public health problem in Ethiopia that is more common in women of reproductive age. However, it is not well addressed and there is a lack of information on its prevalence and associated factors in women of reproductive age group. Therefore, the objective of this study was to assess goiter prevalence and associated factors among women of reproductive age in the Demba Goffa Woreda, Gamo Goffa Zone, and Southwest Ethiopia.Methods: A community-based cross-sectional study was used among 584 randomly selected women in the reproductive age group from February 05 to April 20, 2016. A simple random sampling technique was used to select the study Kebeles, and a systematic random sampling technique was used to select the study samples. Data were collected through a pretested questionnaire, and the goiter examination was done clinically for each participant. The collected data were coded and entered into a computer for statistical analysis using Epi-data version 3.2 and analyzed using SPSS version 20. Variables with a P-value ≤ 0.25 in bivariate logistic regression analysis were entered into multivariate logistic regression analysis, and finally, variables with a P-value < 0.05 in multivariate logistic regression were considered significantly associated with the dependent variable.Results: The total goiter rate was 43%, 95% CI = (39.2-46.9). Cassava consumption (AOR: 2.02, 95% CI: (1.03-4)), salt wash before use (AOR: 3.14, 95% CI: (1.1-11.3)), salt use after > 2 months of purchase (AOR: 11, 95% CI; (5-26)), family history of goiter (AOR: 4.6, 95% CI: (1.4-15.8)), and poor knowledge of iodized salt (AOR: 2.7, 95% CI (1.4-5.5)) were significant factors associated with goiter.Conclusion: Iodine deficiency was found to be severe in women of reproductive age in the study area. This showed that women of reproductive age, especially during pregnancy, are exposed to iodine deficiency and its adverse effects at delivery. Thus, they need urgent supplementation with iodine, improved access to foods rich in iodine and intake of iodized salt. Additionally, health education should focus on the importance of iodized salt, the proper method of use and the prevention of iodine deficiency, which are highly recommended to minimize the problem.
Bowel Necrosis in Patient with Severe Case of COVID-19: A Case Report
Authors: Soeselo Daniel Ardian , Theresia Sandy , Hambali Wirawan 
Published: October 2020

Abstract
Background: In patients who are critically ill with COVID-19, multiple extrapulmonary manifestations of the disease have been observed, including gastrointestinal manifestations. Case Presentation: We present a case of a 65 year old man with severe COVID-19 pneumonia that developed hypercoagulation and peritonitis. Emergent laparotomy was performed and we found bowel necrosis in two sites. Conclusions: Although rare, the presentation of COVID-19 with bowel necrosis requires emergency treatments, and it has high mortality rate.
Computational analysis by molecular docking of thirty alkaloid compounds from medicinal plants as potent inhibitors of SARS-CoV-2 main protease
Authors: A. Tunga Kuhana , Kilembe Jason T. , Matondo Aristote , Yussuf Khamis M. , Nininahazwe Lauraine , Nkatu Fils K. , Tshingamb Milka N. , Vangu Emmanuel K. , Kindala Junior T. , Mihigo Shetonde O. , Kayembe Sungula J. , Kafuti Yves S. , Clement Agboyibor , Taba Kalulu M. 
Published: October 2020

Abstract
2020 has been highly affected by the COVID-19 outbreak. The urgent needs for a potent and effective drug for treatment of this malignance put pressure on researchers and scientists worldwide to develop potential drug or a vaccine to resist SARS-CoV-2. We report in this paper the assessment of the efficiency of thirty alkaloid compounds derived from African medicinal plants against the SARS-CoV-2 main protease through molecular docking and bioinformatics approaches. The results reveal four potential inhibitors (ligands 18, 21, 23 and 24) with the highest binding energies up to 12.26 kcal/mol with good profile of ADMET, as well as fully obey the Lipinski’s rule of five.
Female Labor Force Participation under COVID-19 Pandemic:Evidence from the first round of the Uganda High-frequency Phone Survey on COVID-19
Authors: James Mukoki , Douglas Candia Andabati , Kurayish Ssebulime , Edward Musoke 
Published: October 2020

Abstract
The outbreak of the novel coronavirus that causes COVID-19 disease has taken the world by storm, given the containment measures better known as the Standard Operating Procedures (SOPs), including strict or mild lockdowns and social distancing measures. The impact of these aggregated measures have caused not only loss of lives but also financial, economic, social and even political unrest around the world and Uganda has not been spared either, given its weak economic and health care system (UBOS 2020). This study thus was designed to investigate the impact of COVID-19 lockdown measures and its associated self-reported threat on the female labor force participation (FLFP) in Uganda following the March 20th 2020 shutdown of the economy by the government. The interest in women in this study stems from the fact that despite economic activity shutdown, women’s work and roles extend beyond their office space to their home. Therefore using the first round of the Uganda High-Frequency Phone Survey on COVID-19 (UHFS) dataset conducted by Uganda Bureau of Statistic (UBOS) following the lockdown measure, our results indicates a 17% reduction in FLFP in the early days of the economic shutdown. We further find larger impacts of lockdown on female labor force participation in extreme cases where both partners are under locked down. These impacts are more pronounced among women with children as opposed to those without children. Conversely our results indicates larger impacts of lockdown among those with initial conditions of unemployment prior to the outbreak than those who were employed in time following the pandemic outbreak. We see our results as being consistent with the famous household labor theories. Our results point to the need for preferential treatment for women to encourage and enhance their labor market participation in times of pandemic. Lastly social programs targeting particularly women should be designed and implemented under the ministry of Gender Labor and Social Development.
Pulmonary Imaging Findings in Coronavirus Disease 2019 (COVID-19): A Series of 140 Latin American Children
Authors: Ugas-Charcape Carlos , Ucar María Elena , Almanza-Aranda Judith , Rizo-Patrón Emiliana , Rantes Claudia Lazarte , Caro-Domínguez Pablo , Cadavid Lina , Pérez-Marrero Lizbet , Fazecas Tatiana , Gómez Lucía , Curiel Mariana Sánchez , Pacheco Walter , Rizzi Ana , García-Bayce Andrés , Bendeck Efigenia , Montaño Walter , Daltro Pedro , V José D. Arce 
Published: October 2020

Abstract
Background:The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 virus), which resulted in the worldwide COVID-19 pandemic of 2020, has particularly affected Latin America. Objective:The purpose of the study was to analyze the imaging findings of pulmonary COVID-19 in a large pediatric series.Materials and methods:Children with confirmed SARS-CoV-2 infection confirmed by either quantitative reverse transcription-polymerase chain reaction from nasopharyngeal swabs or presence of circulating IgM and/or IgG antibodies and who underwent chest radiograph (CXR) and/or computed tomography (CT) were included in this retrospective multicenter study. Three pediatric radiologists independently reviewed CXRs and CTs to identify the presence, localization, distribution and extension of pulmonary lesions. Results:One hundred and forty children (71 female; median age 6.2 years; interquartile range 1.6-12.1 years) were included in the study. Peribronchial thickening (93%), ground glass opacities (79%) and vascular engorgement (63%) were the most frequent findings on 131 CXRs. Ground glass opacities (91%), vascular engorgement (84%) and peribronchial thickening (72%) were the most frequent findings on 32 CTs. Peribronchial thickening (100%), ground-glass opacities (90%) and pulmonary vascular engorgement (74%) were common CXR findings in asymptomatic patients (n=20). Consolidation and ground-glass opacity were significantly higher in patients who needed ICU admission or expired, in contrast with patients with a good outcome (48% and 91%, vs 24% and 70% p<0.05, respectively).Conclusion:Asymptomatic children and those with mild symptoms of COVID-19 showed mainly peribronchial thickening, ground-glass opacities and pulmonary vascular engorgement on CXRs. Ground glass opacity and consolidation, were more common in patients who required ICU admission or died.
RASTROS DE UM ENCENADOR EM MOVIMENTO NA MONTAGEM DE “ABOIÁ”.
Authors: Cordeiro Diniz Algoniz Alex 
Published: October 2020

O presente artigo trata da poética da travessia (DINIZ, 2015) como procedimento pedagógico na formação de novos encenadores, para tanto, além de dialogar teoricamente com (COUTINHO, 2018) “poética do aprender e (COUTINHO e HADERSHPEK, 2019) “Pedagogia de Si”, o autor, tendo o Grupo de Teatro Archétypos da UFRN como lócus e a experiência encenador na montagem do espetáculo “Aboiá” reflete sua atuação percebendo aproximações e distancias entre o encenar e o ensinar.
Palavras-chave: Caderno de encenação, Encenar, Pedagogia teatral e Grupo de Teatro Archétypos.