bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of stopping and starting indoor residual spraying on malaria burden in 14 districts of Uganda
Authors: Namuganga Jane , Epstein Adrienne , Nankabirwa Joaniter , Mpimbaza Arthur , Kiggundu Moses , Sserwanga Asadu , Kapisi James , Arinaitwe Emmanuel , Gonahasa Samuel , Opigo Jimmy , Ebong Chris , Staedke Sarah , Shililu Josephat , Okia Michael , Rutazaana Damian , Maiteki-Ssebuguzi Catherine , Belay Kassahun , Kamya Moses , Dorsey Grant , Rodriguez-Barraquer Isabel 
Published: December 2020

Abstract
The scale-up of malaria control efforts has led to marked reductions in malaria burden over the past twenty years, but progress has slowed. Implementation of indoor residual spraying (IRS) of insecticide, a proven vector control intervention, has been limited and difficult to sustain partly because questions remain on its added impact over widely accepted interventions such as bed nets. Using data from 14 enhanced surveillance health facilities in Uganda, a country with high bet net coverage yet high malaria burden, we estimate the impact of starting and stopping IRS. We show that stopping IRS resulted in a 5-fold increase in malaria incidence within 10 months, but reinstating IRS led to an over 5-fold decrease within 8 months. In areas where IRS was initiated and sustained, malaria incidence dropped by 85% after year 4. IRS could play a critical role in achieving global malaria targets, particularly in areas where progress has stalled.
Synergizing strong metal-support interactions and spatial confinement boosts dynamics of atomic nickel for hydrogenations
Authors: Gu Jian , Jian Minzhen , Huang Li , Sun Zhihu , Pan Yang , Yang Jiuzhong , Wen Wu , Lin Yue , Wang Hui-Juan , Liu Xinyu , Wang Leilei , Shi Xianxian , Huang Xiaohui , Cao Lina , Chen Si , Zheng Xu-Sheng , Pan Haibin , Zhu Junfa , Wei Shiqiang , Li Wei-Xue , Lu Junling 
Published: December 2020

Abstract
Atomically dispersed metal catalysts maximize atom efficiency and display unique catalytic properties compared to regular metal nanoparticles. However, achieving high reactivity while still preserving high stability at high loadings remains as a grand challenge. Here we solve the challenge by synergizing strong metal-support interactions and spatial confinement, which enable to fabricate highly loaded (3.1 wt%), active and stable atomic Ni and dense atomic Cu grippers (8.1 wt%) on a graphitic C3N4 support. For semi-hydrogenation of acetylene in excess of ethylene, the fabricated catalyst shows 11 times higher activity than the atomic Ni alone, high ethylene selectivity (90%), and high stability against both sintering and coke formation for 350 h. Comprehensive microscopic and spectroscopic characterization and theoretical calculations reveal the active site of the bridging Ni confined in two hydroxylated Cu grippers, whose structure changes dynamically by breaking interfacial Ni-support bonds upon reactant adsorption and making these bonds upon product desorption. Such a dynamic effect confers high activity/selectivity and high stability, providing an avenue to rational design of efficient, stable, highly loaded, yet atomically dispersed catalysts.
Identification of Care Tasks for the Use of Wearable Transfer Support Robots – An Observational Study at Nursing Facilities Using Robots on A Daily Basis
Authors: Kato Kenji , Yoshimi Tatsuya , Tsuchimoto Shohei , Mizuguchi Nobuaki , Aimoto Keita , Itoh Naoki , Kondo Izumi 
Published: December 2020

Abstract
Background: To reduce the physical burden of caregivers, wearable transfer support robots are highly desirable. Although these robots are reportedly effective for specific tasks in experimental environments, there is little information about their effectiveness at nursing care facilities. The aim of this study was to identify care tasks and operations suitable for the use of these robots among caregivers in nursing facilities where these robots have been in use on a daily basis.Methods: A 1-min observational time-motion analysis was conducted to examine care tasks and operations in two nursing facilities where wearable transfer support robots, namely Muscle Suit or HAL®, Lumbar Type for Care Support, have routinely been used on a daily basis for more than 24 months.Results: Analysis of the care tasks and their time ratio while wearing the equipment revealed that both robots were conspicuously used for direct care in over 70% of transits, especially during transfer assistance and toileting care. Furthermore, these robots were used intensively in the morning along with wake-up calls to care recipients, where pre-assigned wearers used them as part of their “routine work.”Conclusions: We found that these wearable transfer support robots enabled effective performance of care tasks and operations in nursing facilities where these robots have been used on a daily basis for an extended period of time. These results may lead to the effective implementation and sustained operation of other types of care robots in the future.Trial registration: UMIN Clinical Trials Registry no. UMIN000039204. Trial registration date: January 21, 2020. Interventional study. Parallel, non-randomized, single blinded.
Serum Biomarker Profile Orchestrating the Seroconversion Status of Patients With Autoimmune Diseases Upon Planned Primary&nbsp;17DD Yellow Fever Vaccination
Authors: Costa-Rocha Ismael Artur , Machado Ketty , Campi-Azevedo Ana Carolina , Teixeira-Carvalho Andréa , Peruhype-Magalhães Vanessa , Lima Sheila Maria , Miranda Emily , Trindade Gisela , Casagrande Thays , Miyamoto Samira , Deotti Sávio , Rocha Priscila , Serrano Erica , Dinis Valquiria , Gouvêa Sônia , Gavi Maria Bernadete , Silva Lidia , Duque Ruben , Gianordoli Ana Paula , Bissoli Maria de Fatima , Gouvea Maria da Penha , Pinto-Neto Lauro , Burian Ana Paula , Fantinato Francieli , Pileggi Gecilmara , Mota Licia Maria , Valim Valéria , Martins-Filho Olindo 
Published: December 2020

Abstract
The present study aimed to investigate whether the serum biomarkers of immune response orchestrate the seroconversion status in patients with autoimmune diseases (AID) upon planned primary 17DD-YF vaccination. For this purpose a total of 161 individuals were enrolled in a prospective study, including patients with rheumatoid arthritis (RA=38), spondyloarthritis (SpA=51), systemic lupus erythematosus (SLE=21) and Sjögren’s syndrome (SS=30) along with a group of healthy controls (HC=21). Analysis of PRNT titers, seropositivity rates along with the 17DD-YF viremia and serum biomarker was carried out at distinct time-points (D0/D3-4/D5-6/D7/D14-28). The results demonstrated an overall lower PRNT titers and seropositivity rate (170 vs. 448; 77% vs .95%) in AID as compared to HC, especially in SpA and SLE subgroups. No significant differences were observed in the viremia levels amongst groups. In general, a more prominent serum biomarker response was observed in AID as compared to HC, throughout the timeline kinetics. Remarkably, AID/PRNT(-) exhibited higher levels of several biomarkers at baseline as compared to AID/PRNT+. Moreover, while AID/PRNT(+) exhibited earlier increase in serum biomarkers at D3-4/D5-6, the AID/PRNT(-) displayed higher response at later time-points (D7/D14-D28). Of note, a synchronic increase of IFN-g at the peak of viremia (D5-6) was observed in HC and AID/PRNT(+) groups, whereas a later asynchronous IFN-g response was reported for AID/PRNT(-) at D7. The biomarker profile tends to deflate at post-vaccination timeline, highlighting a putative immunomodulatory effect of live attenuated 17DD-YF vaccine in AID/PRNT(+), but not in AID/PRNT(-). Altogether these data suggested that inflammatory status prior vaccination, low INF-g at viremia peak and the occurrence of asynchronous biomarker storm after 17DD-YF vaccination may orchestrate the lack of antibody response.
Active tobacco smoking is associated with lower risk of acquiring SARS-CoV-2 infection among people living with HIV
Authors: Fernandez-Fuertes Marta , Corma-Gomez Anaïs , Rodriguez-Pineda Elena , Fuentes-Lopez Ana , Rincon Pilar , Serrano-Conde Esther , Real Luis M , Garcia Federico , Macias Juan , Pineda Juan A 
Published: December 2020

Abstract
Importance: Information about risk factors for SARS-CoV-2 infection and COVID-19 outcome among people living with human immunodeficiency virus (PLWH) is limited. Furthermore, the impact of smoking on the risk of developing COVID-19 is unclear and has been a matter of controversy.Objective: To evaluate the relationship between current tobacco smoking and the probability of SARS-CoV-2 infection acquisition among PLWH.Design: Retrospective nested case-control study performed within a cohort of 702 PLWH.Settings: University Hospital in Spain (February-October 2020).Participants: Cases were the 18 patients from this cohort with a confirmed diagnosis of COVID-19. Control group included the remaining 684 PLWH without a diagnosis of COVID-19.Exposure: Active tobacco smoking vs. non-smoking, using self-reported electronic health record data.Outcome and Measure: Development of COVID-19. Diagnosis of COVID-19 was established by the detection of SARS-CoV-2 RNA or antigen by PCR or EIA, respectively, or by the presence of plasma SARS-CoV-2 antibodies by ECLIA.Results: In 11 (61.1%) of the 18 patients, COVID-19 diagnosis was based on PCR, 4 (22.2%) on antigen and 3 (16.7%) on serology determinations. In the control group, 380 (54.1%) individuals were also tested. Regarding clinical spectrum, 2 (11.1%) patients were asymptomatic, 12 (66.6%) had upper-respiratory tract infections and 2 (11.1%) had viral pneumonia and one (5.6%) individual showed extra respiratory symptoms. One (5.6%) patient developed severe pneumonia and died. Three hundred and sixty-nine (52.6%) individuals were active smokers, 2 (11.1%) at the COVID-19 diagnosis and 367 (54.1%) in control group (p=0.001). In the bivariate analysis, only tobacco smoking was associated with a greater risk of COVID-19 [unadjusted OR=9.41 95% Confidence Interval (95% CI, 2.15-41.24); p=0.003]. Multivariate analysis, adjusted by sex, tobacco smoking and Charlson index, showed that tobacco smoking was independently related to a higher probability of SARS-CoV2 infection [aOR=9.42 (95% CI 2.15-41.33), p = 0.003].Conclusion and Relevance: Active tobacco smoking is associated with a lower incidence of SARS-CoV-2 infection in PLWH. The underlying mechanisms by which tobacco smoking may protect against SARS-CoV-2 infection should be further investigated. In the meanwhile, public-facing messages about a protective effect of tobacco smoking on the risk of COVID-19 must be avoided.
Antimicrobial and Antioxidant Activities of Extracts and Compounds From Trifolium Baccarinii With Their Mechanisms of Antibacterial Action
Authors: Feugap Léonel , Kengne Irene , Tamokou Jean-De-Dieu , Ngnokam Claudia , Djamalladine Mahamat , Voutquenne-Nazabadioko Laurence , Ngnokam David 
Published: December 2020

Abstract
The treatment of infectious diseases with antimicrobial agents continues to present problems in modern-day medicine with many studies showing significant increase in the incidence of bacterial resistance to several antibiotics. The screening of plant extracts and natural compounds for antimicrobial activity has demonstrated that higher plants represent a potential source of new anti-infective agents. The aim of this study was to evaluate the antimicrobial and antioxidant activities of extracts and compounds from the whole plant Trifolium baccarinii Chiov. with their mechanisms of antibacterial action. Biochanin A (1), formononetin (2), luteolin (3), luteolin-4'-O-β-D-glucopyranoside (4), 4,7,2'-trihydroxy-4'-methoxyisoflavanol (5), sissotrin (6), 1-méthyl-β-D-glucopyranoside (7), ononin (8), D-mannitol (9) and 3-O-β-D-glucuronopyranosylsoyasapogenol B (10) were isolated from T. baccarinii. The MeOH, EtOAc and n-BuOH extracts as well as compounds 1–6 from T. baccarinii displayed the most antimicrobial and antioxidant activities. The MeOH extract and compound 5 exhibited antibacterial activity through bacteriolytic effect and reduction of the antioxidant defenses in the bacterial cells. Interestingly, none of the tested samples showed cytotoxic activity against normal cells; highlighting their good selectivity toward pathogenic bacteria and yeasts. Hence, they are promising lead candidates with antibacterial potential against methicillin resistant S. aureus (MRSA).
Breast surgery on the post-operative well-being of women: a cross-sectional study
Authors: Ranieri Jessica , Fiasca Fabiana , Guerra Federica , Mattei Antonella , Giacomo Dina Di 
Published: December 2020

Abstract
Background. Mammoplasty is the most common surgery that is used for both breast augmentation in healthy women (aesthetic plastic) and breast reconstruction (disease-related plastic) in women who have been diagnosed with and surgically treated for regional breast cancer with radical mastectomy (MRM). When compared to breast reconstruction surgery, aesthetic breast surgery is perceived to result in more favourable aesthetic outcomes.. This study aimed to examine the long-term effects of mammoplasty on the psychological adaptation of women.Methods. A total of 44 30–50-year-old women participated in this study. They were divided into two groups based on the type of breast surgery that they had undergone (augmentation surgery [AS] vs. reconstruction surgery [RS]) and the time that had elapsed since their surgery (≤ 3 years vs. > 3 years). Results. Our findings suggest that the psychological well-being of women who undergo AS declines over time. The women who had undergone AS ≤ 3 and > 3 years earlier did not differ in any of the indicators of emotional functioning. The only exception was their level of satisfaction with their breasts.We examined the impact of mammoplasty on the satisfaction levels and well-being of women who had undergone RS (after MRM). As expected, they were less satisfied with their breasts than those who belonged to the AS group However, this was true only among those who had undergone their surgery ≤ 3 years earlier.Conclusions. In conclusion, our findings underscore the need to provide psychological support to those who have undergone AS and RS. To shorten the adaptation process and enhance their mental well-being, personalised psychological interventions should be provided.
The Use of 117mSn&nbsp;(Tin) Colloid for Treatment of Naturally Occurring Grade 3 Elbow Osteoarthritis in Client Dogs
Authors: Donecker John , Fabiani Michelle , Gaschen Lorrie , Aulakh Karanvir 
Published: December 2020

Abstract
BackgroundThe pathology associated with elbow dysplasia is progressive and irreversible and long-term prognosis is poor. Evidence has revealed the important role synovitis plays in the pathophysiology of osteoarthritis. The use of radiosynoviothesis has been proposed as an alternative in early therapeutic intervention to prevent, delay or limit joint disease progression. The aim of this study was to evaluate the effect and duration of improvement following intra-articular injection of 117mSn colloid on naturally occurring Grade 3 elbow osteoarthritis in dogs. Dog elbows (15 dogs/27 elbows) were injected with 117mSn colloid and cohorts followed check point assessments on Days 90, 180, 270 and 365 post treatment. Effectiveness was evaluated using: 1) Canine Brief Pain Inventory (CBPI) assessed by the caretaker, and 2) clinician-assessed lameness. Complete blood count, chemistry panel, joint fluid analysis and urinalysis were assessed for safety.ResultsAt least half the dogs showed success at each study time check point (Days 90, 180, 270 and 365) compared with baseline, using the validated CBPI User Guide criteria. Day 270 provided the largest percentage (70%) of successes when compared with baseline. These CBPI findings were corroborated by statistical agreement with success of clinician-assessed lameness. The mean Pain Severity Score (PSS) improved significantly at Days 90, 270 and 365 compared to baseline, while the mean Pain Interference Score (PIS) improved significantly at Day 270 compared to baseline. Safety assessments did not reveal concerns for the study duration.ConclusionsDogs diagnosed with Grade 3 osteoarthritis in at least one elbow benefited by either not worsening or improving over 365 days after treatment with 117mSn colloid. No 117mSn colloid-related safety concerns were observed.
Identification of Potential Genes both Differentially Expressed and Regulated by Differential Methylation Regions in Oral Squamous Cell Carcinoma
Authors: Niu Yan , Sun Changsheng , Shan Qiusheng 
Published: December 2020

Abstract
Background: The aberrant methylation included hypermethylation and hypomethylation plays significant role in the progression of many kind of cancers but poorly investigated in oral squamous cell carcinoma (OSCC). Methods: GSE123781 and GSE87053 were used to identify the differential methylation regions (DMRs) by R software. the targeted genes regulated by DMRs were predicted by wANNOVAR. The biological process, cellular component, molecular function and cell pathways of common targeted genes between GSE123781 and GSE87053 were analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes pathway (KEGG) enrichment analysis. The hub genes in common targeted genes both associated with cancer biological process and cancer cell pathways were identified by protein to protein interaction network (PPI). Finally, the expression level of hub genes and correspondence relationship with head and neck squamous cell carcinoma (HNSCC) patient survival were confirmed by The Cancer Genome Atlas (TCGA) dataset. Results: There are 372 common targeted genes regulated by DMRs between GSE123781 and GSE87053 and RUNX family transcript factor 1 (RUNX1), phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma (PIK3CG), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta (PIK3CD), laminin subunit beta 1 (LAMB1), integrin subunit alpha M (ITGAM), interleukin 2 receptor subunit alpha (IL2RA), interleukin 10 (IL10), FYN proto-oncogene, Src family tyrosine kinase (FYN), cholinergic receptor muscarinic 1 (CHRM1) and C-C motif chemokine receptor 1 (CCR1) are hub genes in common targeted genes. Furthermore, RUNX1, PIK3R1, PIK3CD, LAMB1, ITGAM, IL2RA, IL10, FYN, CHRM1 and CCR1 differentially expressed in HNSCC tissues and the overexpressed genes PIK3CD, LAMB1 and IL10 could lead to the decrease of HNSCC patient survival. Conclusions: PIK3CD, LAMB1 and IL10 both differentially expressed and regulated by DMRs are quite associated with the progression of OSCC and the survival of HNSCC patients, which has much potential to be new biomarkers in targeted therapy of OSCC.
miR-130b Acts as an Oncogene and Prognostic Biomarker of Breast Cancer: A Bioinformatic Analysis
Authors: Chen Xinyue , Hao Lijun 
Published: December 2020

Abstract
Background: Breast cancer (BC) is the most prevalent cancer among females globally. microRNAs (miRNAs) could regulate the expression levels of cancer-related genes through binding with target mRNAs. In various cancers, the abnormal expression of miR-130b has been detected. We aims to investigate the molecular mechanism and biological function of miR130b in breast cancer.Methods: We obtained two microRNA expression profiles from the Gene Expression Omnibus (GEO) database, including GSE45666 and GSE26659. We identified differentially expressed miRNAs (DE-miRNAs) between BC tissue and normal breast tissue based on the GEO2R web tool. DE-miRNAs were filtered by significant prognostic value resulting from Kaplan–Meier plotter. We used the JASPAR database to explore upstream regulators of miR-130b. The potential molecular mechanisms of miR-130b correlation genes were revealed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis in WebGestalt. Protein–protein interaction (PPI) network of miR-130b target genes was constructed by STRING. Cytoscape software was used to visualize the PPI network and hub genes.Results: miR-130b was highly expressed in breast cancer tissues, which positively correlates with poor prognostic. JASPAR revealed THAP11 might be the upstream regulator of miR-130b. In addition, GO, and KEGG pathway revealed that miR-130b positively regulated PFKP, STAT1, SRC, and NOTCH2, participating in the Thyroid hormone signaling pathway. The PPI network further identified that AR, KIT, and ESR1 as hub genes in BC development.Conclusion: miR-130b, which is regulated by THAP11, acts as an oncogene and prognostic biomarker in BC by mediating the Thyroid hormone signaling pathway and potential target genes. miR-130b might be a novel therapeutic target for BC treatment.
Factors Affecting Prediction Error after Cataract Surgery with Implantation of Various Multifocal IOLs in Patients with Previous Refractive Laser Surgery
Authors: Yoo Young-Sik , Kang Min Chae , Park Jongyeop , Kwon Hyung-Goo , Chung Eui-Sang , Lim Dong Hui , Chung Tae-Young 
Published: December 2020

Abstract
This study aimed to compare the clinical outcomes of implantation of various multifocal intraocular lenses (mIOLs) and the prediction accuracy of two intraocular lens (IOL) power calculation formulas for eyes that underwent previous corneal refractive surgery. Four types of mIOLs (TECNIS Symfony (Group I), AcrySof IQ PanOptix (Group II), LENTIS Mplus (Group III), and TECNIS mIOL (Group IV)) were used and the IOL power was calculated with the two no-history methods, Shammas-PL and Barrett True-K. Visual acuity and refractive outcomes including manifest refraction, prediction error (PE), absolute error (AE), and median absolute error (MedAE) were evaluated at three months after the cataract surgery. For all groups the Barrett True-K formula produced a narrower range of PEs and lower MedAE than Shammas-PL. Eyes of lower predictive accuracy (group B, AE > 0.5D) showed weak uncorrected distance visual acuity resulting from myopic refractive error and target refraction when compared to that of higher predictive accuracy (group A, AE ≤ 0.5 D). Targeting emmetropia using the Barrett True-K is recommended in patients undergoing mIOL implantation with prior corneal refractive surgery. Additionally, history of prior large amount of laser ablation seems to be an important factor related to low predictive accuracy.
Visual Acuity, Contrast Sensitivity Function, and Twilight Vision of Soft and Rigid Gas-Permeable Contact Lens Wearers
Authors: Krolo Iva , Kasumović Aida , Radman Ivana , Sabol Ivan , Ravlić Maja Malenica , Vicković Ivanka Petric 
Published: December 2020

Abstract
The authors have requested that this preprint be removed from Research Square.