bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of an organ-based tube current modulation tool in pediatric CT examinations
Authors: Papadakis Antonios E. , Damilakis John 
Published: May 2020

Abstract
Objectives
To investigate the effect of an organ-based tube current modulation (OTCM) technique on organ absorbed dose and assess image quality in pediatric CT examinations.

Methods
Four physical anthropomorphic phantoms that represent the average individual as neonate, 1-year-old, 5-year-old, and 10-year-old were used. Standard head and thorax acquisitions were performed with automatic tube current modulation (ATCM) and ATCM+OTCM. Dose calculations were performed by means of Monte Carlo simulations. Radiation dose was measured for superficial and centrally located radiosensitive organs. The angular range of the OTCM exposure window was determined for different tube rotation times (t) by means of a solid-state detector. Image noise was measured as the standard deviation of the Hounsfield unit value in regions of interest drawn at selected anatomical sites.

Results
ATCM+OTCM resulted in a reduction of radiation dose to all radiosensitive organs. In head, eye lens dose was reduced by up to 13% in ATCM+OTCM compared with ATCM. In thorax, the corresponding reduction for breast dose was up to 10%. The angular range of the OTCM exposure window decreased with t. For t = 0.4 s, the angular range was limited to 74° in head and 135° for thorax. Image noise was significantly increased in ATCM+OTCM acquisitions across most examined phantoms (p < 0.05).

Conclusions
OTCM reduces radiation dose to exposed radiosensitive organs with the eye lens and breast buds exhibiting the highest dose reduction. The OTCM exposure window is narrowed at short t. An increase in noise is inevitable in images located within the OTCM-activated imaged volume.

Key Points
• In pediatric CT, organ-based tube current modulation reduces radiation dose to all major primarily exposed radiosensitive organs.
• Image noise increases within the organ-based tube current modulation enabled imaged volume.
• The angular range of the organ-based tube current modulation low exposure window is reduced with tube rotation time.
Effectiveness of the clinical decision support tool ESR eGUIDE for teaching medical students the appropriate selection of imaging tests: randomized cross-over evaluation
Authors: Diekhoff Torsten , Kainberger Franz , Oleaga Laura , Dewey Marc , Zimmermann Elke 
Published: May 2020

Abstract
Objectives
To evaluate ESR eGUIDE—the European Society of Radiology (ESR) e-Learning tool for appropriate use of diagnostic imaging modalities—for learning purposes in different clinical scenarios.

Methods
This anonymized evaluation was performed after approval of ESR Education on Demand leadership. Forty clinical scenarios were developed in which at least one imaging modality was clinically most appropriate, and the scenarios were divided into sets 1 and 2. These sets were provided to medical students randomly assigned to group A or B to select the most appropriate imaging test for each scenario. Statistical comparisons were made within and across groups.

Results
Overall, 40 medical students participated, and 31 medical students (78%) answered both sets. The number of correctly chosen imaging methods per set in these 31 paired samples was significantly higher when answered with versus without use of ESR eGUIDE (13.7 ± 2.6 questions vs. 12.1 ± 3.2, p = 0.012). Among the students in group A, who first answered set 1 without ESR eGUIDE (11.1 ± 3.2), there was significant improvement when set 2 was answered with ESR eGUIDE (14.3 ± 2.5, p = 0.013). The number of correct answers in group B did not drop when set 2 was answered without ESR eGUIDE (12.4 ± 2.6) after having answered set 1 first with ESR eGUIDE (13.0 ± 2.7, p = 0.66).

Conclusion
The clinical decision support tool ESR eGUIDE is suitable for training medical students in choosing the best radiological imaging modality in typical scenarios, and its use in teaching radiology can thus be recommended.

Key Points
• ESR eGUIDE improved the number of appropriately selected imaging modalities among medical students.
• This improvement was also seen in the group of students which first selected imaging tests without ESR eGUIDE.
• In the student group which used ESR eGUIDE first, appropriate selection remained stable even without the teaching tool.
Euro-Atlantic weather Regimes in the PRIMAVERA coupled climate simulations: impact of resolution and mean state biases on model performance
Authors: Fabiano F. , Christensen H. M. , Strommen K. , Athanasiadis P. , Baker A. , Schiemann R. , Corti S. 
Published: May 2020

AbstractRecently, much attention has been devoted to better understand the internal modes of variability of the climate system. This is particularly important in mid-latitude regions like the North-Atlantic, which is characterized by a large natural variability and is intrinsically difficult to predict. A suitable framework for studying the modes of variability of the atmospheric circulation is to look for recurrent patterns, commonly referred to as Weather Regimes. Each regime is characterized by a specific large-scale atmospheric circulation pattern, thus influencing regional weather and extremes over Europe. The focus of the present paper is the study of the Euro-Atlantic wintertime Weather Regimes in the climate models participating to the PRIMAVERA project. We analyse here the set of coupled historical simulations (hist-1950), which have been performed both at standard and increased resolution, following the HighresMIP protocol. The models’ performance in reproducing the observed Weather Regimes is assessed in terms of different metrics, focussing on systematic biases and on the impact of resolution. We also analyse the connection of the Weather Regimes with the Jet Stream latitude and blocking frequency over the North-Atlantic sector. We find that—for most models—the regime patterns are better represented in the higher resolution version, for all regimes but the NAO-. On the other side, no clear impact of resolution is seen on the regime frequency of occurrence and persistence. Also, for most models, the regimes tend to be more tightly clustered in the increased resolution simulations, more closely resembling the observed ones. However, the horizontal resolution is not the only factor determining the model performance, and we find some evidence that biases in the SSTs and mean geopotential field might also play a role.
High PD-1 expression level is associated with an unfavorable prognosis in patients with cervical adenocarcinoma
Authors: Ishikawa Masako , Nakayama Kentaro , Nakamura Kohei , Yamashita Hitomi , Ishibashi Tomoka , Minamoto Toshiko , Iida Kouji , Razia Sultana , Ishikawa Noriyoshi , Nakayama Satoru , Otsuki Yoshiro , Kyo Satoru 
Published: May 2020

AbstractPurposeThe effectiveness of immunotherapy for cervical adenocarcinoma (CA) has not been demonstrated yet. Programmed cell death 1 (PD-1), programmed cell death-ligand 1 (PD-L1), and CD8 may be used as biomarkers of response to immune therapy in CA patients. In the present study, we aimed to investigate whether the expression levels of PD-1, PD-L1, and CD8 can predict the prognosis of patients with CA and their response to immune checkpoint inhibition therapy.MethodsIn the present study, the clinical stage for all 82 patients with cervical adenocarcinoma was classified according to the guidelines of the International Federation of Gynecology and Obstetrics (FIGO); there were 5, 48, 5, 14, 8, and 2 patients with stage IA, IB, IIA, IIB, IIIB, and IVB disease, respectively. The levels of PD-1, PD-L1, and CD8 were analyzed by the immunohistochemical analysis of the formalin-fixed paraffin-embedded tumor samples. The correlation between the expression levels and patient prognosis was analyzed using the Kaplan–Meier method and univariate and multivariate Cox proportional hazard regression models.ResultsWe observed a significant inverse correlation between the expression of PD-1 and CD8 (p = 0.001, chi-square test). We also found a significant inverse correlation between the expression of PD-L1 and CD8 (p = 0.027). The overall survival and progression-free survival rates were significantly worse in patients with positive PD-1 expression (p = 0.031;p = 0.087, respectively).ConclusionOur results suggest that a high PD-1 expression is associated with a poor prognosis in patients with CA. Further research is necessary to identify the molecular mechanisms that mediate this association.
Low-tropospheric humidity inversions over Europe: spatiotemporal variability and relations to temperature inversions’ occurrence
Authors: Palarz Angelika , Celiński-Mysław Daniel 
Published: May 2020

AbstractTropospheric humidity inversions are an important component of the Earth’s climate system as well as a significant factor affecting the global radiation budget and cloud formation. Their occurrence enlarges the amount of downward longwave radiation trapped near the Earth’s surface and provides moisture to maintain the top of clouds from evaporation. The aim of this paper is to examine the spatiotemporal variability of the humidity inversions over Europe. For the first time, we provide also a comprehensive analysis of relations between the humidity inversions and temperature inversions over the domain considered. The study is based on data derived from the ERA-Interim reanalysis for the period 1981–2015. We have confirmed that the temporal and spatial variability of the humidity inversions is strongly related to inversion type. The mean seasonal frequency of surface-based humidity inversions (SBHI) usually does not exceed 20%, while the mean seasonal frequency of elevated humidity inversions (EHI) ranges from 5 to 60% depending on the region and season. On average, EHI are substantially deeper and stronger than SBHI. We found also that the low-tropospheric humidity inversions often occur simultaneously with the temperature inversions. Moderate positive correlations exist, however, only among the parameters (depth and strength) of the same inversion type, but not between the humidity inversions and the temperature inversions. Considering the links between EHI and ETI (elevated temperature inversions) parameters, slightly higher values of the Spearman’s rank correlation coefficient (ρs > 0.50) are found between EHI base height and ETI base height. Nonetheless, the simultaneous occurrence of EHI and ETI usually fosters the intensity of both inversion types.
Auswirkungen der Corona-Krise auf die europäische Klimaschutzpolitik
Authors: Treptow Thomas M. 
Published: May 2020

ZusammenfassungNeben vielen anderen negativen Folgen hat die Corona-Krise auch direkte Auswirkungen auf den EU-weiten Handel mit Emissionszertifikaten für Treibhausgasemissionen. Dieser stellt einen Eckpfeiler der europäischen Klimaschutzpolitik dar. Den kurzfristig geringer zu erwartenden Treibhausgasemissionen stehen aufgrund der erwarteten Rezession mittel- und langfristig niedrigere Preise für Emissionsrechte gegenüber. Diese machen die gegenwärtigen Produktionstechnologien tendenziell attraktiver. Dadurch wird eine wesentliche Zielsetzung europäischer Klimaschutzpolitik, der ökonomisch-rationale Wechsel der Unternehmen auf klimafreundlichere Produktionstechnologien, erschwert.
Towards sustainable community conservation in tropical savanna ecosystems: a management framework for ecotourism ventures in a changing environment
Authors: Mudzengi Boycen Kumira , Gandiwa Edson , Muboko Never , Mutanga Chiedza Ngonidzashe 
Published: May 2020

AbstractThe sustainability of ecotourism ventures under the Community Based Natural Resources Management in Zimbabwe is under stress due to environmental changes emanating from effects associated with socioeconomic factors, climate change and epidemic diseases. Using an in-depth analysis of the Mahenye ecotourism venture from the year 1982 to 2020 as a case study, this study sought to propose a management framework for ecotourism ventures in a changing environment by examining the sustainability of community conservation initiatives in Zimbabwe. Research methods included expert opinion from two natural resources governance academics, desktop research and authors’ experiences about Mahenye ecotourism venture. Results indicated that the Mahenye ecotourism venture has faced significant challenges but has been resilient to withstand the shocks such as population increase, exclusion of youths and women, climate change, hyperinflation, donor fatigue, reduced international ecotourist visitation and international hunting bans emanating from socioeconomic and political environmental changes. These shocks have a negative effect on the main elements of an ecotourism venture such as the wildlife resources, amenities, attraction, accessibility, management system, marketing, beneficiaries and linkages. The management framework highlights the interventions that can be made to enable ecotourism ventures in changing environments to remain sustainable. The interventions are promoting strong community cohesion, developing sustainable self-funding mechanisms, promoting multiple sources of income, carrying targeted environmental education programs, capacity building in managing ecotourism in periods of hyperinflation, improved marketing and offering a unique experience, promoting climate smart ecotourism, promoting domestic ecotourism visits, implementing effective feedback systems among stakeholders to decrease uncertainties and lobbying to have hunting bans removed.
A Negotiation Protocol for Fine-Grained Accountable Resource Provisioning and Sharing in e-Science
Authors: Meng Zeqian , Brooke John , Han Junyi , Sakellariou Rizos 
Published: May 2020

AbstractWith the increasing demand for dynamic and customised resource provisioning for computational experiments in e-Science, solutions are required to mediate different participants’ varied demands for such resource provision. This paper presents a novel negotiation protocol based on a new collaboration model. The protocol allows e-Scientists, the manager of an e-Scientist’s collaboration, and resource providers to reach resource provisioning agreements. By considering the manager of an e-Scientist collaboration for negotiation decisions, the protocol enables fine-grained accountable resource provision on a per job basis for e-Scientist collaborations, without binding the e-Scientist collaboration to resource providers. A testbed built with the protocol is also presented, making use of a production e-Science gateway, use cases, and infrastructures. The testbed is experimentally evaluated, via designed scenarios and comparison with existing production tools. It demonstrates that the proposed negotiation protocol can facilitate accountable resource provision per job, based on resource sharing rules defined and managed by e-Scientist collaborations.
Using emojis in mobile web surveys for Millennials? A study in Spain and Mexico
Authors: Bosch Oriol J. , Revilla Melanie 
Published: May 2020

AbstractTo involve Millennials in survey participation, and obtain high-quality answers from them, survey designers may require new tools that better catch Millennials' interest and attention. One key new tool that could improve the communication and make the survey participation more attractive to young respondents are the emojis. We used data from a survey conducted among Millennials by the online fieldwork company Netquest in Spain and Mexico (n = 1614) to determine how emojis can be used in mobile web surveys, in particular in open-ended questions, and how their use can affect data quality, completion time, and survey evaluation. Overall, results show a high willingness of Millennials to use emojis in surveys (both stated and actual use) and a positive impact of encouraging Millennials to use emojis in open-ended questions on the amount of information conveyed, the completion time and the survey enjoyment.
Transformation and ecotoxicological effects of iodinated X-ray contrast media
Authors: Nowak Agnieszka , Pacek Gabriela , Mrozik Agnieszka 
Published: May 2020

AbstractIodinated X-ray contrast media (ICM) such as diatrizoate, iohexol, iomeprol, iopamidol, and iopromide are commonly used in medical imaging for radiological visualization of a variety of anatomic structures. Because of their highly persistent nature and poor removal by conventional wastewater treatment, ICM can often remain unchanged after entering the environment or they are transformed into many different by-products in complex physical, chemical, and biological processes. Large amounts of ICM and their by-products are found in natural waters, groundwater, drinking water (up to 100 µg/L), and even in soil, where they can be a potential threat to the inhabitants of these environments. Because knowledge about the fate of ICM in various environments is dispersed and it concerns specific areas, the main purpose of this review is to summarize the available information about their occurrence, chemical and biological transformation/degradation, and toxicity to living organisms. The topics discussed particularly focus on mechanisms of ICM degradation/transformation in water using advanced oxidation processes and the biotransformation/biodegradation of ICM by microorganisms under different conditions, as well as the toxicity of ICM and their transformation by-products to humans and other organisms. Although environmental risk is not expected from the parent compounds of ICM, their continuous input to the water and the formation of toxic by-products may constitute a long-term potential risk for living organisms. Therefore, monitoring the transport and fate of ICM in various environments seems necessary.
Gustav Shpet’s Transcendental Turn
Authors: Bourgeot Liisa 
Published: May 2020

AbstractShpet’s interpretation of Husserl’s phenomenology has caused puzzlement because of the lack of clarity with which he treats the transcendental turn in Appearance and Sense (1914). I suggest that we find a more comprehensive discussion on the topic in Shpet’s 1917 article, “Wisdom or Reason?” There, Shpet reacts to Husserl’s treatment of a cluster of problems related to the latter’s transition to transcendental idealism. I read “Wisdom or Reason?” not only in relation to Husserl’s Logos article of 1911, but also to his 1907 lecture series “The Idea of Phenomenology.” My analysis of Shpet’s phenomenology reveals that he followed through with the transcendental turn, although his philosophy developed in a direction different from Husserl’s transcendental idealism. Shpet postulates a collective consciousness, in which meaning-constitution takes place, and discovers the “word” as the foundation for any cognition. Shpet’s phenomenology remains ontological, as he considers language or culture as the “form of being” in which human beings live. In “Wisdom or Reason?,” Shpet argues that we can have direct knowledge of this meaningful reality: being is not “represented” but “presented” in a word. A certain compatibility thus exists between Shpet’s phenomenology of cultural reality and Husserl’s search for the absolute validity of knowledge.
Collective Complicity in War Crimes. Some Remarks on the Principle of Moral Equality of Soldiers
Authors: Cebula Adam 
Published: May 2020

AbstractThe article critically analyzes one of the central assumptions of Michael Walzer’s version of just war theory, as presented in his main work devoted to war ethics. As requested by the author of Just and Unjust Wars, the controversial nature of the principle of the moral equality of soldiers is revealed by discussing the actual course of events of a historical military conflict – namely, the outbreak of World War II, one of the main issues dealt with in Walzer’s book. The exclusion of individual responsibility of people involved in a military operation which finds no moral justification seems to entail a number of consequences that put a heavy burden on Walzer’s overall model of military ethics. In order to ensure the necessary level of coherence of just war theory one may need to modify Walzer’s principle of the moral equality of soldiers – at least in relation to the participants of total war.
Evaluating the Control of Money Laundering and Its Underlying Offences: the Search for Meaningful Data
Authors: Levi Michael 
Published: May 2020

AbstractThis article examines the political and criminological history of anti-money controls, including the involvement of Asian countries and the varied motivations and interests engaged. It goes on to review where empirical evidence has been used and can be used in fighting the financial components of underlying crimes, examining the denotation of the problem(s) we are supposed to be fighting—money laundering as an evil in itself and/or the underlying crimes which give rise to it; estimates of the size and harmfulness of the problems and identifies any improvements/emerging problems in the assessment of money laundering. It concludes with some reflections on assessing policy effectiveness and the need for greater engagement by criminologists and other social scientists in this process.
Mystical Death in the Spirituality of Saint Teresa of Ávila
Authors: Gálik Slavomír , Gáliková Tolnaiová Sabína , Modrzejewski Arkadiusz 
Published: May 2020

AbstractIn this article, the authors study the phenomenon of mystical death in the spirituality of Saint Teresa of Ávila. They first explain the phenomenon of mystical death in the history of Christian spirituality. The authors note that the history of this phenomenon goes as far back as the New Testament, where it can be found in the texts by St. Paul and St. John, but it was first formulated explicitly by an unknown author much later—in the seventeenth century. Mystical death is a concept used to explain mystics’ experience of transformation from self-centeredness to other-centeredness. The authors want to use this concept to open up a further interpretation of Teresa of Ávila’s work, it provides a key for unlocking a major theme of her work. In the mysticism of Saint Teresa of Ávila, the authors investigate this phenomenon in two of her books: The Interior Castle or The Mansions and The Life of Teresa of Jesus. Firstly, this phenomenon is in her description of the fifth mansion of The Interior Castle or The Mansions in the symbolism of the transformation of a caterpillar into a butterfly, conditioned by ascending of internal energies. Secondly, they can trace the phenomenon of mystical death in her work The Life of Teresa of Jesus, especially in her explanation of her near-death experience. According to the authors, the phenomenon of mystical death in the mysticism of Teresa of Ávila constitutes a condition for higher spiritual states, especially the state of mystical unity (lat. unio). Finally, the authors outline that the phenomenon of mystical death in the spirituality of Teresa of Ávila is similar to mysticism in Eastern spiritual traditions. They discuss the importance of revealing these similarities for a better understanding of the human being and hir further spiritual development.