bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of cardiovascular events in genetically confirmed versus unconfirmed familial hypercholesterolaemia
Authors: Khan Tina Z , Breen Jane , Neves Emma , Grocott-Mason Richard , Barbir Mahmoud 
Published: December 2020

Introduction: Genetic testing for familial hypercholesterolaemia (FH) is not yet established for widespread use internationally to provide diagnostic confirmation, in part due to high cost and resource requirement. We need to establish whether genetic testing is clinically justified in terms of risk stratification and prediction of cardiovascular events.Methods: We performed a single tertiary cardiac centre retrospective evaluation of patients with FH managed within our genetic screening service. We evaluated the prevalence of cardiovascular events in genetically confirmed cases of FH compared to those unconfirmed upon genetic testing, to assess whether gene positivity confers a higher risk phenotype. We also compared the clinical characteristics of the genetically confirmed and unconfirmed group.Results: Amongst adult patients (≥18 years) with genetically confirmed heterozygous FH (n=87), 34% (30/87) had one or more documented CV events. In comparison a lower event rate was observed in adult patients with genetically unconfirmed FH (n=170) with 25% (42/170) experiencing one or more documented CV events. Additional cardiovascular risk factors were more prevalent in the unconfirmed group including hypertension, co- morbidities, higher age and body mass index which may have modified the difference in cardiovascular risk.Conclusion: Genetic testing in FH may be clinically justified and appears to identify a subset of patients with higher risk of cardiovascular events. However, the risk difference is modified by alternative cardiovascular risk factors and co-morbidities which may be more prevalent in genetically unconfirmed FH.
PRELIMINARY ANALYSES OF THE EFFICIENCY OF SUSTAINABLE FILTERS AND HYDROELETRIC POTENTIAL FOR A CLEAN ENERGY GENERATION AND WATER DEPOLLUTION SYSTEM
Authors: De Souza Junyor Flavio , Da Silva Creir , Andrich Filipe , Ronquim Joyce , Pereira Máriam Trierveiler 
Published: December 2020

In last decades, water pollution has become more pronounced on all rivers in Latin America, Africa and Asia. Thus, it is estimated that the deterioration of water quality will extend further over the coming decades, increasing threats to human health, environment and sustainable development. Simultaneously, it has been observed a depletion of non-renewable energetic sources and its increasing replacement by renewable sources. Therefore, the United Nations (UN) has been setting goals regarding sustainable development for the countries. Thus, the present study aimed to create and design a mechanism that integrates clean energy generation and water depollution from small and medium-sized streams by using agro-industrial waste. For this, it was necessary to survey the theoretical framework besides the hydrological study of Pinhalzinho II watershed, which was chosen for the simulation. Thus, it was started the design of the hydroelectric microcentral coupled to a sustainable water purification system using the softwares: AutoCAD© and SketchUp 3D©. In addition, the stream flow was determined and its energy potential was calculated in order to estimate the amount of energy that could be generated by the system. Then, laboratory scale filters were constructed from sugarcane bagasse and cassava peel for efficiency analyses. Finally, the upstream (raw water) and downstream (after filtering) water samples were analyzed and their parameter values determined. After data treatment, it was found that the results were not satisfactory; conversely, they showed a reduction in raw water quality, achieving efficiency only for the thermotolerant coliforms parameter. Nevertheless, regarding the hydroelectric microcentral project and the hydroenergetic potential of the stream, the results were promising.
GENERATION OF RENEWABLE ENERGY THROUGH ROADS, BRIDGES AND CYCLE PATHS
Authors: Gorges Gustavo de Carvalho , Wedekind Johanes Paulo , Kimura Gabriela Akemi Perez , Rosella Jéssica Wasny Martins , Herrero Welysson , Wedekind Joyce Ronquim 
Published: December 2020

Abstract: The economic growing and technological development brought advantages to society. However, the adoption of the sustainable development is necessary so the future generations will not be compromised. In this way, the present work has as its objective presenting a bibliographical review about roads, bridges and bike lanes that generate renewable energy. The photovoltaic panels are very important to generate energy on the roads and, as an example, the acoustic barriers on the roads can be exchanged or implemented with photovoltaic panels to maintain the function of sound barrier and of generator of electric power at the same time. Another way of generating renewable energy are bike lanes, in the Netherlands, as an example, it is utilized a special concrete, superimposed by a layer of highly resistant glass with photovoltaic cells, so the installed floor can convert sunlight into energy. The piezoelectric energy can also generate energy in bike lanes using a pressure-sensitive floor with friction from bicycle tires. When it comes to bridges, a project developed in Italy intends to place solar panels and wind generation turbines in a bridge as a way of generating energy, generating around 40 million kW/h in one year. The proposal of this bridge is to fulfill empty spaces among the existing pillars on the bridge to integrate the system of wind turbines in the structure. It can be concluded that, throughout time, the renewable energies have been standing out and civil construction has shown an important role in this sector, presenting technological solutions and taking advantage of spaces in relation to the implantation of roads, bridges and bike lanes.Key words: Sustainability. Renewable Energy. Photovoltaic Plates. Piezoeletric Energy. Wind Energy.
CHEMICAL AND THERMOANALYTICAL CHARACTERIZATION OF THE PINK PEPPER (Schinus terebinthifolius Raddi) SEEDS ESSENTIAL OIL
Authors: Picolotto Angela Maria , Ariati Angela Maria , Franciscato Lidaiane Mariáh Silva dos Santos , Bittencourt Paulo Rodrigo Stival , Caramão Elina Bastos , Sakai Otávio Akira , Moritz Cristiane Mengue Feniman 
Published: December 2020

The essential oil (EO) of pink pepper has important biological properties that can enhance its application in the pharmaceutical, cosmetic and food industries. The objective of this study was to characterize the EO of pink pepper seeds in terms of their chemical composition and thermophysical properties. Certified pink pepper seeds obtained commercially were used. The EO was extracted by hydrodistillation and chemically characterized in a gas chromatograph coupled to mass spectrometer (GC/MS). The thermoanalytical characterization was performed on a simultaneous high resolution equipment, and the Thermogravimetric Analysis (TG) and Differential Scanning Calorimetry (DSC) were used to determine the physical-chemical and kinetic properties of the OE in the room temperature range up to 250 ºC in the 20 ºC.min-1 ratio under nitrogen atmosphere. The Arrhenius kinetic model was applied to determine the activation energy of the EO. A total of 51 chemical compounds were detected in the pink pepper EO, of which 42 compounds were identified (54.7% of monoterpene compounds and 45.3% sesquiterpenes). The major components were ?-pinene (26.80%), germacrene D (11.25%), sabinene (11.13%) and terpinen-4-ol (8.59%). The thermogravimetric analysis indicated a single stage of thermo-degradation of the pink pepper EO between 74.8 ºC and 184.7 ºC, being an endothermic peak in the physical transition of vaporization. The variation of enthalpy and activation energy of EO were found with values of = - (39.8 ± 9.5) KJ.Kg-1 and = - (2,546 ± 0.033) KJ.mol-1, respectively. The data presented in the thermogravimetric analysis of pink pepper seeds EO allowed observing important thermal parameters for the definition of industrial processes that can use it as raw material, so that its biological activities can remain stable under controlled temperature conditions and below the range degradation.
Public Health Interventions’ Effect on Hospital Use in Patients With COVID-19: Comparative Study
Authors: Wang Xiaofeng , Ren Rui , Kattan Michael W , Jehi Lara , Cheng Zhenshun , Fang Kuangnan 
Published: December 2020

Background
Different states in the United States had different nonpharmaceutical public health interventions during the COVID-19 pandemic. The effects of those interventions on hospital use have not been systematically evaluated. The investigation could provide data-driven evidence to potentially improve the implementation of public health interventions in the future.

Objective
We aim to study two representative areas in the United States and one area in China (New York State, Ohio State, and Hubei Province), and investigate the effects of their public health interventions by time periods according to key interventions.

Methods
This observational study evaluated the numbers of infected, hospitalized, and death cases in New York and Ohio from March 16 through September 14, 2020, and Hubei from January 26 to March 31, 2020. We developed novel Bayesian generalized compartmental models. The clinical stages of COVID-19 were stratified in the models, and the effects of public health interventions were modeled through piecewise exponential functions. Time-dependent transmission rates and effective reproduction numbers were estimated. The associations of interventions and the numbers of required hospital and intensive care unit beds were studied.

Results
The interventions of social distancing, home confinement, and wearing masks significantly decreased (in a Bayesian sense) the case incidence and reduced the demand for beds in all areas. Ohio’s transmission rates declined before the state’s “stay at home” order, which provided evidence that early intervention is important. Wearing masks was significantly associated with reducing the transmission rates after reopening, when comparing New York and Ohio. The centralized quarantine intervention in Hubei played a significant role in further preventing and controlling the disease in that area. The estimated rates that cured patients become susceptible in all areas were small (<0.0001), which indicates that they have little chance to get the infection again.

Conclusions
The series of public health interventions in three areas were temporally associated with the burden of COVID-19–attributed hospital use. Social distancing and the use of face masks should continue to prevent the next peak of the pandemic.
The Book of Evan: The work and life of Evan McAra Sherrard
Authors: Tudor Keith 
Published: December 2020

In many ways Evan McAra Sherrard was a Renaissance man: a master of not one but several trades - agriculture, education, ministry, and psychotherapy - and he liked the fact that he had several strings to his bow. He described his "basic sense of identity" as "a healing minister of religion" and that "my personal competence is as a psychotherapist". To many - family, friends, colleagues, trainees, supervises, and clients - he was compassionate, open hearted, thoughtful, and generous. Evan was intstrumental in setting up the Cameron Centre in Dunedin in the 1960s, the Human Development Team within Presbyterian Support Services in Auckland in the late 1970s, and the Psychotherapy Programme at Auckland Institute (now University) of Technology in the late 1980s. More broadly, he was hugely influentual in the practice, professions and organisation of transactional analysis, psychodrama, psychotherapy, and counselling in New Zealand. This book brings together Evan's mostly unpublished writings in these various fields of interest, together with contributions from some 40 people, including his family, who represent the breadth and depth of influence that Evan's work and life had - and continues to have today.
ANALISIS RISIKO PAJANAN MERKURI (HG) PADA IKAN LAUT YANG DIKONSUMSI OLEH NELAYAN DI PANTAI AMED DAN PANTAI SANUR, BALI
Authors: Lestari Ida Ayu Putri Widya , Suryadhi Made Ayu Hitapretiwi 
Published: December 2020

Merkuri (Hg) merupakan logam berat yang berbahaya dan beracun. Penggunaan merkuri yang tidak disertai dengan pengelolaan limbah dan kemampuan merkuri untuk terakumulasi di dalam lingkungan berkontribusi terhadap peningkatan emisi merkuri. Penelitian ini bertujuan untuk mengetahui sejauh mana kandungan merkuri pada hasil laut dan risikonya terhadap masyarakat di sekitar Pantai Amed Karangasem dan Pantai Sanur Denpasar yang terletak di Provinsi Bali. Penelitian menggunakan pendekatan analisis risiko kesehatan lingkungan (ARKL), dengan teknik pengambilan sampel purposive sampling dan teknik pemilihan responden simple random sampling. Sampel merupakan jenis ikan yang dominan dikonsumsi oleh subjek penelitian di masing-masing lokasi penelitian, dan responden atau subjek penelitian yang digunakan yakni nelayan. Penentuan kadar Hg dilakukan dengan Spektrofotometer Serapan Atom (AAS). Hasil uji menunjukkan rata-rata kandungan Hg pada sampel yang berasal dari Pantai Sanur sebesar 0,162 µg/g, lebih tinggi bila dibandingkan dengan sampel dari Pantai Amed sebesar 0,024 µg/g. Berdasarkan analisis risiko diperoleh nilai risk quotient sebesar 1,09 (RQ > 1) untuk respondent dari Pantai Sanur dan risk quotient sebesar 0,18 (RQ ? 1) untuk respondent dari Pantai Amed.
Seluruh sampel ikan yang diuji terdeteksi mengandung Hg namun, belum melewati ambang batas aman. Berdasarkan perhitungan analisis risiko, kandungan Hg pada sampel ikan dari Pantai Sanur berpotensi menimbulkan risiko kesehatan bagi responden yang mengonsumsinya, namun diperlukan adanya penelitian lanjutan untuk memastikan hasil tersebut.
Kata kunci : merkuri, ikan, nelayan, ARKL.
KEJADIAN KATARAK PADA KELOMPOK NELAYAN “PUTRA SAMUDRA” DI DESA LEBIH, GIANYAR, BALI TAHUN 2016
Authors: Andiyani Ni Kadek Nening , Muliawan Partha 
Published: December 2020

Cataract is the most prevalent cause of blindness in the world. Based on occupation, cataract was higher among farmer, fisherman, and labor workers. This study aims to measure the prevalence of cataract among fishermen of the “Putra Samudra” fisherman group at Lebih village. This was a cross-sectional study with quantitative descriptive approach. Samples were 70 fishermen of the 187 members of “Putra Samudra” fishermen group. Sampling technique was simple random sampling. Instrument for the study was questionnaire and direct ophthalmoscope. The result showed that 18.6% of the fishermen have cataract. Cataract prevalence was significantly higher among the fishermen ?50 year old, lower education and those who did not wear specific protection aids. It is necessary to provide education on the importance of specific protection aids to prevent cataract. It is also necessary to develop occupational health program that include medical check-up prior working time, regular and specific, also health care for occupational health problems among fishermen.
Keywords : Bali, cataract, fishermen, exposure to sun ray
FAKTOR YANG BERHUBUNGAN DENGAN SKOR POLA PANGAN HARAPAN PADA RUMAH TANGGA SASARAN DI DESA BATUKANDIK, NUSA PENIDA
Authors: Dewi Anak Agung Sagung Putri Kusuma , Utami Ni Wayan Arya 
Published: December 2020

Expected Food Pattern (EFP) is composition of dietary diversity based on energy contribution on the main food. It was known that EFP score of Bali Province year 2014 was remaining low (58,2%). Low EFP score was mainly found in poor household and the largest number of poor households in year 2013 were found in di Batukandik village of Nusa Penida Island. This study aimed to describe household EFP score, number of family members, mother’s knowledge about nutrition, family income level, household food expenditure, diet prohibition and land ownership status with EFP score. This quantitative study was conducted with cross sectional design. Samples were 64 poor household which selected by cluster random sampling. Data was analyzed univariate and bivariate using chi square test. Result showed that mother’s knowledge about nutrition (OR= 4,21; 95%CI OR=1,20-15,78; p=0.01), family income level (OR= 10; 95%CI OR= 1,99-63,72; p=0.00) and household food expenditure (OR= 6,28; 95%CI OR= 1,47-37,12, p=0.00) were significantly associated with PPH score. Meanwhile number of family members, diet prohibition land ownership status was not significantly associated with EFP score.
Keywords: Expected Food Pattern, nutrition, family income, food expenditure
UJI KERENTANAN NYAMUK AEDES SP. TERHADAP FOGGING INSEKTISIDA MELATHION 5% DI WILAYAH KOTA DENPASAR TAHUN 2016
Authors: Kusuma I Wayan Darma , Purnama Sang Gede 
Published: December 2020

ABSTRAKNyamuk Aedes sp. adalah vektor penyakit Demam Berdarah Dengue (DBD) di Indonesia. Salah satu pengendalian vektor DBD adalah dengan melakukan fogging menggunakan insektisida. Tujuan dari penelitian ini adalah untuk mengetahui tingkat kerentanan nyamuk Aedes sp. terhadap fogging insektisida melathion 5% di wilayah kota Denpasar sebagai daerah endemis DBD. Penelitian ini merupakan jenis penelitian eksperimental murni dengan rancangan penelitian post-test only with control group design. Jumlah sampel yang digunakan dalam penelitian ini adalah 200 ekor nyamuk dewasa yang dibagi ke dalam kerangka besi masing-masing 25 ekor. Hasil dari penelitian menunjukkan bahwa nyamuk Aedes sp. masih rentan terhadap insektisida melathion dengan konsentrasi 5% dengan kematian 100% dalam waktu 60 menit di dalam maupun di luar ruangan rumah. Berdasarkan hasil tersebut dapat disimpulkan bahwa daya bunuh fogging insektisida melathion 5% terhadap nyamuk Aedes sp. di wilayah Kota Denpasar secara umum masih efektif dan tidak terdapat perbedaan daya bunuh fogging insektisida melathion 5% terhadap nyamuk Aedes sp. di dalam rumah dengan di luar rumah.Keywords: Aedes sp, Melathion, Resistensi.
ABSTRACTAedes Sp. Is a vector of Dengue Hemorrhagic Fever (DHF) in Indonesia. Among many ways to control DHF, fogging technique using Insecticides is commonly used. The purpose is this study was to determine susceptibility of the Aedes sp. against fogging of 5% malathion insecticide in the Denpasar city area as a DHF endemic area. This research is a pure experimental research with post-test only with control group design. The number of samples used in this study were 200 adult mosquitoes which were divided into an iron frame of 25 individuals each. The study showed that the Aedes sp. still susceptible to malathion insecticide with a concentration of 5% with 100% death within 60 minutes inside and outside the home. Based on the study it can be concluded that fogging technique using 5% Malathion is effective to kill Aedes Sp. The study also found that there is no difference result of killing power by applying 5% Malathion inside and outside the house.Keywords: Aedes Sp., Malathion, Resistance
PROSES PENGAMBILAN KEPUTUSAN UNTUK BERHENTI MENGGUNAKAN NARKOBA PADA MANTAN PECANDU NARKOBA DI WILAYAH DENPASAR
Authors: Afriani Merry S , Sari Komang Ayu Kartika 
Published: December 2020

ABSTRAKBerhenti menggunakan narkoba merupakan kesulitan terberat bagi seorang pecandu karena sering sekali pecandu mengalami sugesti serta rasa sakit. Penelitian ini bertujuan untuk menggambarkan perilaku penggunaan, pemulihan kecanduan narkoba, dan proses pengambilan keputusan untuk berhenti. Metode kualitatif dengan rancangan studi kasus digunakan dalam penelitian ini, dimana lima orang informan dipilih dengan menggunakan metode purposive sampling. Pengumpulan data dilakukan dengan wawancara mendalam yang selanjutnya dianalisis dengan menggunakan thematic analysis. Teknik pengecekan keabsahan data dilakukan dengan cara peer debriefing dan studi literatur. Hasil penelitian menunjukkan bahwa hanya dua informan yang melewati semua tahapan proses berhenti yang dimulai dari tahapan menilai informasi baru, melihat alternatif-alternatif yang ada, mempertimbangkan alternatif, membuat komitmen, dan bertahan meskipun ada feedback negatif. Faktor terbesar yang dapat mempengaruhi keberhasilan untuk berhenti menggunakan narkoba adalah niat kuat dalam diri dan adanya dukungan keluarga yang positif. Penelitian ini menunjukkan bahwa keberhasilan berhenti menggunakan narkoba dipengaruhi oleh niat dan adanya dukungan positif dari keluarga.Kata Kunci : Pengguna Narkoba, Proses Pengambilan Keputusan, Dukungan Keluarga
ABSTRACTQuitting drugs is one of the most challenging goal for a drug addict because the addicts frequently face withdrawal and pain. This study aims to describe drugs use behavior, rehabilitation of drug addiction and decision-making process to quit drugs. Qualitative method with case study approach was applied on this study. Five informants were selected by purposive sampling. Data were collected by in-depth interviews which then analysed with thematic analysis. Data validity techniques applied for the study were peer debriefing and literature review. Study result revealed only two informants went through all stages of quitting process, starting from receiving new information, exploring available alternatives, making commitment and sustaining despite presence of negative feedbacks. The biggest factors that influence success of quitting drugs are strong internal motivation and positive family supports. This study showed that strong internal motivation and positive family supports are influential to the success of quitting drugs.Keywords: Drug, Decide, Family support
ANALISIS PENERIMAAN SISTEM INFORMASI E-PUSKESMAS DI KABUPATEN BADUNG BERDASARKAN TECHNOLOGY ACCEPTANCE MODEL
Authors: Alvian Viky Yudi , Widarsa I Ketut Tangking 
Published: December 2020

ABSTRAK
Penerapan sistem informasi e-Puskesmas di Kabupaten Badung masih memiliki beberapa masalah yaitu kualitas jaringan internet yang belum memadai sehingga operator kesulitan dalam menginput data pasien. Permasalahan berikutnya yaitu gangguan pada fitur untuk melakukan rujukan pasien. Oleh karena itu, perlu dilakukan penelitian untuk mengetahui bagaimana penerimaan operator terhadap sistem informasi e-Puskesmas. Penelitian ini merupakan penelitian analitik kuantitatif dengan rancangan cross sectional. Besar sampel sebanyak 65 orang pegawai yang mengoperasikan e-Puskesmas. Metode pemilihan sampel yang digunakan adalah cluster random sampling. Instrumen penelitian berupa kuesioner yang mengacu pada Technology Acceptance Model. Hasil dari penelitian ini yaitu 76,92% responden menyatakan sistem informasi e-Puskesmas berguna, sebesar 61,54% responden menyatakan mudah digunakan, dan sebesar 80% responden menyatakan menerima penggunaan sistem informasi e-Puskesmas. Namun, masih terdapat masalah yaitu kualitas jaringan internet belum merata, menambah beban pekerjaan, data pada sistem tidak sesuai dengan hasil pencatatan manual, kesulitan dalam memahami tampilan antarmuka sistem, kode ICD-X masih diinput secara manual, gangguan pada fitur untuk melakukan rujukan pasien, dan belum ada fitur untuk melakukan permintaan obat ke gudang obat dinas kesehatan. Penerapan sistem ini masih perlu diperbaiki dengan dengan peningkatan kualitas jaringan internet, penambahan operator di puskesmas dan puskesmas induk, perbaikan sistem untuk mengurangi terjadinya error, pelatihan terhadap penggunaan sistem, penambahan fitur kode ICD-X dalam sistem, perbaikan fitur rujukan pasien, dan penambahan fitur untuk permintaan obat ke gudang farmasi dinas kesehatan.
Kata Kunci : Penerimaan operator, Sistem Informasi e-Puskesmas, Technology Acceptance Model (TAM)