bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment Outcomes of Clopidogrel in Patients With ACS and Diabetes Undergoing PCI-analysis of Beijing Medicare Database
Authors: Wang Weihao , Wang Xiaoxia , Zhang Lina , Zhang Jie , Man Fuli , Pan Qi , Guo Lixin 
Published: August 2020

Abstract
Background

There are several clinical trials that proved the efficacy of clopidogrel treatment for patients with percutaneous coronary intervention. There are few large-scale research to explore the mortality associated with different duration use of clopidogrel in patients with diabetes and ACS undergoing PCI in the Chinese population.
Objectives

The objective of this analysis was to determine the efficacy of long-term clopidogrel therapy(≥ 12 months) versus short-term use(< 12 months) in Chinese patients with diabetes after PCI.
Methods

Using the Beijing Medicare database provided by Beijing Medical Security Bureau. The Beijing Medicare database contains medical data of about 16 million people, including about 990,000 patients with diabetes and a history of taking antidiabetic medicines. Patients were divided into two groups, one group of 9,116 patients receiving consecutive clopidogrel for one year or more, and another group of 3290 patients receiving consecutive clopidogrel less than one year. The primary of this analysis was the risk of all-cause death, myocardial infarction and revascularization.
Results

In patients with diabetes after PCI, long-term clopidogrel treatment was associated with a reduced risk of all-cause death(HR, 0.57[95%CI, 0.49–0.67], P < 0.0001), myocardial infarction(HR, 0.79[95%CI, 0.68–0.93], P = 0.0035) and an increased risk of angina(HR, 1.18[95%CI, 1.10–1.27], P < 0.0001]) and revascularization(HR, 1.07[95%CI, 1.01–1.13], P = 0.02]). There was no significant difference in the incidence of all-cause re-hospitalization(P = 0.7529), diabetes-related re-hospitalization and cerebrovascular re-hospitalization.
Conclusion

The present study concluded that long-term dual anti-platelet therapy including clopidogrel and aspirin could decrease the risks of all-cause death, myocardial infarction. But it could increase the risks of angina and revascularization. Further studies should interpret the cause of this question.
COVID-19 and Ischemic Stroke
Authors: Sidig Amira , Abbasher Khabab , Abbasher Hussien , Alhusseini Radi Tofaha , Elsayed Mohamed , Abbasher Mohammed , N Sufian Khalid M. , Hajnoor Khalid , Malekaldar Mohammed , Digna Mutaz F. , Hussien Abbasher , Hamid Omer Eladil A. 
Published: August 2020

Abstract
Background: SARS-CoV-2 causes COVID-19 disease. It was identified in December 2019 and rapidly evolved into a pandemic. During the outbreak of COVID-19, researches demonstrated its effect on many systems, including the nervous system. In our clinic, we have reported an impact of SARS-CoV-2, causing the ischaemic stroke.Case Report: A 62-year-old Sudanese male with some comorbidities brought to the A&E with fever, chest symptoms, and acute evolving left-sided hemiplegia power grade 0/5 MRCS with left upper motor neuron facial palsy. Investigations: CT brain: right middle cerebral artery MCA infarction. CT- chest: bilateral ground-glass appearance. COVID-19 Test was positive. elevated D-dimer and C-reactive protein.Discussion: A retrospective study of data from the COVID-19 outbreak in China showed that the incidence of stroke among hospitalized patients was approximately 5%. The fact that COVID-19 is an acute inflammatory condition associated with an increased incidence of fatty plaques formation, injury of the vascular wall, and hypercoagulability, causing brain infarct can be a reasonable hypothesis.ConclusionPatients with COVID-19 are at increased risk of thrombo-embolization, leading to arterial and venous cerebrovascular accident. This case report enhances the importance of further studies to clarify the relationship between stroke and COVID-19.
A previously unknown source of reactor radionuclides in the Baltic Sea, identified by 233, 236, 238U and 127, 129I multi-fingerprinting
Authors: Qiao Jixin , Zhang Haitao , Steier Peter , Hain Karin , Hou Xiaolin , Vartti Vesa-Pekka , Henderson Gideon , Eriksson Mats , Aldahan Ala , Possnert Goran 
Published: August 2020

Abstract
We present the first application of multi-isotopic fingerprints (i.e., 236U/238U, 233U/236U, 236U/129I and 129I/127I) for the discovery of unrevealed radioactive sources. Our data indicate that, besides the reactor signature from the two European reprocessing plants and global fallout signature, there must be a previously undiscovered additional reactor 236U source in the Baltic Sea. This reactor 236U may come from unreported discharges from nuclear research facilities in Sweden, or it may come from accidental leakage from disposal of spent nuclear fuel on the Baltic seafloor, either reported or unreported. Such leakage would indicate potential problems with the safety of seafloor disposal, and may be accompanied by leakage of other radionuclides. The results demonstrate the high sensitivity of the multi-isotopic tracer systems, especially the newly accessible 233U/236U signature, to distinguish environmental emissions of unrevealed historical or present radioactive releases for nuclear safeguard and emergency preparedness, as well as tracing environmental processes from the releasing sites.
The Relationship between Intraoperative Cerebral Oximetry and Postoperative Delirium in Patients Undergoing off-pump Coronary Artery Bypass Graft Surgery: A Retrospective Study
Authors: Lim Leerang , Nam Karam , Lee Seohee , Cho Youn Joung , Yeom Chan-Woo , Jung Sang Hyup , Moon Jung Yoon , Jeon Yunseok 
Published: August 2020

Abstract
Background Cerebral oximetry has been widely used to measure regional oxygen saturation in brain tissue, especially during cardiac surgery. Despite its popularity, there have been inconsistent results on the use of cerebral oximetry during cardiac surgery, and few studies have evaluated cerebral oximetry during off pump coronary artery bypass graft surgery (OPCAB). Methods To evaluate the relationship between intraoperative cerebral oximetry and postoperative delirium in patients who underwent OPCAB, we included 1,439 patients who underwent OPCAB between October 2004 and December 2016 and among them, 815 patients with sufficient data on regional cerebral oxygen saturation (rSO2) were enrolled in this study. We retrospectively analyzed perioperative variables and the reduction in rSO2 below cut-off values of 75%, 70%, 65%, 60%, 55%, 50%, 45%, 40%, and 35%. Furthermore, we evaluated the relationship between the reduction in rSO2 and postoperative delirium. Results Delirium occurred in 105 of 815 patients. In both univariable and multivariable analyses, the duration of rSO2 reduction was significantly longer in patients with delirium at cut-offs of <50% and 45% (for every 5 min, adjusted odds ratio(OR) 1.007 [95% Confidence interval (CI) 1.001 to 1.014] and adjusted OR 1.012 [1.003 to 1.021]; p=0.024 and 0.011, respectively). The proportion of patients with an rSO2 reduction <45% was significantly higher among those with delirium (adjusted OR 1.737[1.064 to 2.836], p=0.027). Conclusions In patients undergoing OPCAB, intraoperative rSO2 was associated with postoperative delirium. The cut-off values for intraoperative rSO2 were 50% for the total patient population and 55% for patients younger than 68 years.
Assessing Fidelity to Family-Based Treatment: Expert, Therapist, Parent, and Peer Ratings
Authors: Couturier Jennifer , Kimber Melissa , Barwick Melanie , McVey Gail , Findlay Sheri , Webb Cheryl , Niccols Alison , Lock James 
Published: August 2020

Abstract
Introduction: Fidelity is an essential component for evaluating the clinical and implementation outcomes related to delivery of evidence-based practices (EBPs). Effective measurement of fidelity requires clinical buy-in, and as such, requires a process that is not burdensome for clinicians and managers. As part of a larger implementation study, we examined fidelity to Family-Based Treatment (FBT) measured by several different raters including an expert, a peer, therapists themselves, and parents, with a goal of determining a pragmatic, reliable and efficient method to capture treatment fidelity to FBT.
Methods: Each therapist audio-recorded at least one FBT case and submitted recordings from session 1, 2, and 3 from phase 1, plus one additional session from phase 1, two sessions from phase 2, and one session from phase 3. These submitted files were rated by an expert and a peer rater using a validated FBT fidelity measure. As well, therapists and parents rated fidelity immediately following each session and submitted ratings to the research team. Inter-observer reliability was calculated for each item using the intraclass correlation coefficient (ICC), comparing the expert ratings to ratings from each of the other raters (parents, therapists, and peer). Mean scale scores were compared using repeated measures ANOVA.
Results: Intraclass correlation coefficients revealed that agreement was the best between expert and peer, with excellent, good, or fair agreement in 7 of 13 items from session 1, 2 and 3. There were only four such values when comparing expert to parent agreement, and two such values comparing expert to therapist ratings. The rest of the ICC values indicated poor agreement. Scale level analysis indicated that expert fidelity ratings for phase 1 treatment sessions scores were significantly higher than the peer ratings and, that parent fidelity ratings tended to be significantly higher than the other raters across all three treatment phases. There were no significant differences between expert and therapist mean scores.
Conclusions: There may be challenges inherent in parents rating fidelity accurately. Peer rating or therapist self-rating may be considered pragmatic, efficient, and reliable approaches to fidelity assessment for real-world clinical settings.
Intergenerational neurocognitive effects of intrauterine hyperglycemia on male offspring
Authors: Zou Kexin , Ren Jun , Zhang Junyu , Zhou Chengliang , Luo Sisi , Tan Chengxi , Lv Pingping , Sun Xiao , Sheng Jianzhong , Huang Hefeng , Liu Xinmei , Ding Guolian 
Published: August 2020

Abstract
Background

Studies on human and animals suggest associations between gestational diabetes mellitus (GDM) with increased susceptibility to develop neurological disorders in offspring. However, researches have focused on the neurodevelopment consequences of the first filial (F1) offspring. We hypothesize that the intrauterine hyperglycemia exposure will alter epigenetic reprogramming in F1 sperm, and carry risks of passing on molecular defects to the second filial (F2).
Results

We found that intrauterine hyperglycemia exposure resulted in memory impairment in both F1 and F2 males from the F1-GDM male offspring. Transcriptome profiling of F1 and F2 hippocampi revealed that differentially expressed genes were enriched in learning, memory, cognition, neurotransmission, synaptic plasticity, and postsynaptic specialization. Again, enrichment curves computed by Gene set enrichment analysis (GSEA) of F1 hippocampi were highly consistent with F2. Interestingly, combined analysis of F1 sperm methylome and gene expression of F2 hippocampi screened out several hypermethylation-low expression genes which are associated with abnormal central nervous system development (particularly synapse development and homeostasis), such as Camk2b, Dlgap1, Wnt5a, Tubb2b and so on.
Conclusions

These findings implicate that the male germ line is a major player in transgenerational phenotypic transmission. Taken together, our results for the first time suggest that intrauterine hyperglycemia leads to transgenerational cognitive impairment, and, sperm methylome is a potential epigenetic mechanism for the effects of GDM.
WITHDRAWN: Bio-sensored Diagnostic Kit for Detecting Tuberculosis Using Artificial Intelligence Through Neural Networks
Authors: Tamilselvi S , Kumar N.M Saravana , Lavanya S , Hariprasath K , Kavinya A , Kaviyavarshini N 
Published: August 2020

Abstract
The advancement and well-developed technologies in global medical field, tuberculosis remains a major health problem. To solve the problem of tuberculosis, artificial intelligence (AI) provides the way for solving problem in real world and enlightens the world in bringing a human's brain to a machine. This paper aims to detect the presence of mycobacterium tuberculosis infection within a short span of time compared to ancient technique. It is designed in such a way that the breath of the infected person can be used to diagnose the disease at premier stage. The main objective is to design and implement a portable diagnostic kit for Tuberculosis using Neural Networks and Artificial Intelligence. The tool kit called Electronic Nose which is significant artificial intelligent component constructed through neural network contains a biosensor having an electrode coated with the galectin. The signals of hybridization on binding will be captured and processed by machine learning sensor and the output is displayed using artificial intelligence. Earlier case of diagnosis approached on the basis of grouping microorganisms days together. But this study faster to find the report in an hour. Therefore the time taken for diagnosing the presence of the bacterium can be reduced and this also paves the way for starting the treatment immediately.
Identification of Cancer Stem Cell-related Biomarkers in Intestinal-Type and Diffuse-Type Gastric Cancer by Stemness Index and Weighted Correlation Network Analysis
Authors: Guo Rui , Chu Aining , Gong Yuehua 
Published: August 2020

Abstract
BackgroundCancer stem cells (CSCs) play an important role in drug resistance, recurrence, and metastasis of tumors. Considering the heterogeneity of tumors, this study aimed to explore the key genes regulating stem cells in intestinal-type and diffuse-type gastric cancer (GC).MethodsRNA-seq data and related clinical information were downloaded from The Cancer Genome Atlas (TCGA). Based on the mRNA expression-based stemness index (mRNAsi), important modules and key genes were identified by weighted co-expression network analysis (WGCNA). The expression of key genes were further verified by Oncomine database.ResultsMRNAsi scores of GC were significantly higher than that of normal tissue. Besides mRNAsi scores of intestinal-type GC (IGC) were significantly higher than that of diffuse-type GC (DGC). WGCNA showed that the brown modules for both types of GC were the most significantly associated with mRNAsi. We screened out 7 and 43 key genes for IGC and DGC, and found that these genes were closely related, respectively. Functional analysis showed the relationship between the key genes confirmed in Oncomine database and fate of cells. ConclusionsIn this study, 7 and 43 genes related to the characteristics of CSCs were identified in IGC and DGC, respectively. These genes were associated with cell cycle and homologous recombination, which could serve as therapeutic targets for the inhibition of stem cells from both types of GC.
Organisational Measures and Strategies for a Healthy and Sustainable Extended Working Life and Employability
Authors: Nilsson Kerstin 
Published: August 2020

Abstract
Background: Due to the global demographic change, a larger amount of people will need to work until an older age, and organisations and enterprises need to make measures in order to facilitate an extended working life. The aim of this study was to investigate and find out organisational measures and suggestions to promote and make improvements for a healthy and sustainable working life for all ages in an extended working life.Methods: The data of the text analysis in this qualitative study was collected through focus group interviews and individual interviews including 133 participants: employees 55- 72 years (87), first line managers (33), trade union representatives (6), HR-professionals (7).Results: This study has identified various suggestions for measures and actions that would increase the employees’ ability to cope in working life until an older age. The measures have been sorted into different themes: to promote a good physical and mental work environment; to promote personal financial and social security; to promote social inclusion and social support in the work situation; and to promote creativity and intrinsic work motivation, i.e. based on the spheres of determination in the theoretical swAge-model. Conclusions: Based on the study results a tool for dialogue and discussion on employee work situation and career development has been developed, and attached to the article. Regular conversations, communication and close dialogue are needed and are a prerequisite for good working conditions and a sustainable working environment, as well as to be able to manage employees and develop the organisation further. The identified measures need to be taken care of regularly throughout employees’ entire working life, in order to enable a healthy and sustainable working life for all ages.
A Novel Circular RNA hsa_circRNA_103809/miR-377-3p/GOT1 Pathway Regulates Cisplatin-Resistance in Non-Small Cell Lung Cancer (NSCLC)
Authors: Zhu Xiang , Han Jing , Lan Huiyin , Lin Qingren , Wang Yuezhen , Sun Xiaojiang 
Published: August 2020

Abstract
Cisplatin is the first-line chemotherapeutic drug for non-small cell lung cancer (NSCLC), and emerging evidences suggested that targeting circular RNAs (circRNAs) became an effective strategy to increase cisplatin-sensitivity in NSCLC, but the detailed mechanisms are still not fully delineated. Based on this, this study identified a novel hsa_circRNA_103809/miR-377-3p/GOT1 signaling cascade contributed to cisplatin-resistance in NSCLC in vitro and in vivo. Mechanistically, the parental cisplatin-sensitive NSCLC (CS-NSCLC) cells were subjected to continuous low-dose cisplatin stimulation to generate cisplatin-resistant NSCLC (CR-NSCLC) cells, and we found that hsa_circRNA_103809 and GOT1 were upregulated, while miR-377-3p was downregulated in CR-NSCLC cells, instead of CS-NSCLC cells. Further experiments validated that hsa_circRNA_103809 sponged miR-337-3p to upregulate GOT1 in CS-NSCLC cells. Interestingly, the gain- and loss-function experiments validated that knock-down of hsa_circRNA_103809 enhanced the inhibiting effects of cisplatin on cell proliferation and viability, and induced cell apoptosis in CR-NSCLC cells, which were reversed by downregulating miR-377-3p and overexpressing GOT1. Consistently, overexpression of hsa_circRNA_103809 increased cisplatin-resistance in CS-NSCLC cells by regulating miR-377-3p/GOT1 axis. Furthermore, the xenograft tumor-bearing mice models were established by using the CR-NSCLC cells, and we proved that silencing of hsa_circRNA_103809 aggravated the inhibiting effects of cisplatin treatment on NSCLC cell growth in vivo. In general, analysis of data suggested that targeting hsa_circRNA_103809/miR-377-3p/GOT1 pathway increased susceptibility of CR-NSCLC cells to cisplatin, and this study provided novel agents to improve the therapeutic efficacy of cisplatin for NSCLC treatment in clinic.
Suspected Heparin-Induced Thrombocytopenia in a COVID-19 Patient on Extracorporeal Membrane Oxygenation Support: A Case Report.
Authors: Phan Xuan T. , Nguyen Tuan Huu , Tran Tung T. , Huynh Thu-Hien T. , Hoang Thuy-Ha T. , Nguyen Vinh-Chau V. , Pham Thao N. T. 
Published: August 2020

Abstract
Background: Extracorporeal membrane oxygenation (ECMO) support can be life-saving in critically ill COVID-19 patients. However, there are many complications associated with this procedure, including Heparin-induced thrombocytopenia (HIT.) Despite its rarity in ECMO cases, HIT can lead to devastating consequences and is difficult to manage.Case presentation: In this report, we present a case of a COVID-19 patient on ECMO support who was diagnosed with HIT and required intensive treatment. Initially, the patient showed no remarkable sign of thrombosis and HIT was only suspected due to newly-developed thrombocytopenia and oxygenator dysfunction. Regarding his treatment, since there was no recommended replacement to heparin available to us at the time of diagnosis, we decided to use Rivaroxaban temporarily. No adverse events were recorded during that period. The patient was able to make a full recovery.Conclusion: HIT may jeopardize patient’s care during ECMO. As COVID-19 may bring about a surge in the number of patients requiring ECMO support, we need consented guidance to optimize treatment in this specific situation.
Sports Nutritionists Adopt the Nutrition Care Process (NCP) Road Map to Develop Individualized Meal Planning for Athletes.
Authors: Mustafa Norashikin , Safii Nik Shanita , Mohamad Mohd Izham , Sameeha Mohd Jamil , Rahman Abdul Hadi Abdul , Ahmad Azimah , Yatiman Noor Hafizah , Zakaria Ahmad Zawawi , Talib Ruzita Abd , Poh Bee Koon 
Published: August 2020

Abstract
Background: It is considered that the implementation of nutrition care process (NCP) leads to more efficient and effective care, as well as enhancing the roles of dietetics and nutrition professionals in the clinical setting. However, little is known about the NCP being implemented in the sports nutrition setting to deliver nutrition care, especially in meal planning. Therefore, this study aims to identify the process that sports nutritionists (SNs) practise in meal planning to plan meals for athletes and identify the application of NCP.Methods: In-depth interviews, using semi-structured interview questions, were conducted with SNs employed at the National Sports Institute of Malaysia. Five SNs who managed different types of sports were recruited. The interviews were audio-recorded and transcribed verbatim. Data were entered into ATLAS.ti 8 and analyzed using thematic analysis.Results: The following processes were identified: (i) collecting pertinent data; (ii) analyzing the collected data; (iii) determining nutrition prescriptions; (iv) formulating goals and determining actions; (v) implementing actions and recommendations; and (vi) monitoring.Conclusions: This study identified 6 general processes practiced by sports nutritionists in meal planning that comprised of the NCP’s interrelated steps, except nutrition diagnosis statement from the Nutrition Diagnosis step of the NCP. A comprehensive process and workflow can help sports dietitians or nutritionists to develop individualized meal plans that can improve athletes’ nutritional status, adherence, health and sports performance.