bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of the COVID-19 Pandemic on Cancer-Related Patient Encounters
Authors: London Jack W. , Fazio-Eynullayeva Elnara , Palchuk Matvey B. , Sankey Peter , McNair Christopher 
Published: July 2020

PURPOSE While there are studies under way to characterize the direct effects of the COVID-19 pandemic on the care of patients with cancer, there have been few quantitative reports of the impact that efforts to control the pandemic have had on the normal course of cancer diagnosis and treatment encounters. METHODS We used the TriNetX platform to analyze 20 health care institutions that have relevant, up-to-date encounter data. Using this COVID and Cancer Research Network (CCRN), we compared cancer cohorts identified by querying encounter data pre-COVID (January 2019-April 2019) and current (January 2020-April 2020). Cohorts were generated for all patients with neoplasms (malignant, benign, in situ, and of unspecified behavior), with new incidence neoplasms (first encounter), with exclusively malignant neoplasms, and with new incidence malignant neoplasms. Data from a UK institution were similarly analyzed. Additional analyses were performed on patients with selected cancers, as well as on those having had cancer screening. RESULTS Clear trends were identified that suggest a significant decline in all current cohorts explored, with April 2020 displaying the largest decrease in the number of patients with cancer having encounters. Of the cancer types analyzed, lung, colorectal, and hematologic cancer cohorts exhibited smaller decreases in size in April 2020 versus 2019 (−39.1%, −39.9%, −39.1%, respectively) compared with cohort size decreases for breast cancer, prostate cancer, and melanoma (−47.7%, −49.1%, −51.8%, respectively). In addition, cancer screenings declined drastically, with breast cancer screenings dropping by −89.2% and colorectal cancer screenings by −84.5%. CONCLUSION Trends seen in the CCRN clearly suggest a significant decrease in all cancer-related patient encounters as a result of the pandemic. The steep decreases in cancer screening and patients with a new incidence of cancer suggest the possibility of a future increase in patients with later-stage cancer being seen initially as well as an increased demand for cancer screening procedures as delayed tests are rescheduled.
High-Risk Human Papillomavirus Persistence and Anal Microbiota Among Nigerian Men Who Have Sex With Men Living With or At Risk for HIV
Authors: Nowak Rebecca G. , Ravel Jacques , Bentzen Søren M. , Schumaker Lisa M. , Ambulos Nicholas P. , Ndembi Nicaise , Dauda Wuese , Mitchell Andrew , Mathias Trevor J. , Crowell Trevor A. , Baral Stefan D. , Blattner William A. , Charurat Manhattan E. , Palefsky Joel M. , Cullen Kevin J. 
Published: July 2020

PURPOSE Noninvasive therapies, such as probiotics that promote local immunity and reduce persistence of high-risk human papillomavirus (HR-HPV), would circumvent challenges in implementing anal cancer screening where same-sex behavior is stigmatized and criminalized. We describe the persistence of HR-HPV and its relationship with the anal microbiota among Nigerian men who have sex with men (MSM). METHODS Anal swabs from HIV-uninfected and -infected MSM who were enrolled in the TRUST/RV368 cohort were HPV genotyped at enrollment and at 3 and 12 months. Participants who presented with the same type(s) of HR-HPV across all visits were categorized as having persistent infections. The anal microbiota composition at baseline of HR-HPV–positive individuals was evaluated. Unsupervised K-means clustering of the 15 most abundant bacterial taxa identified 2 microbial clusters (MC-1 and MC-2). Unadjusted associations of 12-month HR-HPV persistence was evaluated by MC membership and HIV status using χ2 tests and logistic regression. RESULTS One hundred nine HIV-infected and 41 HIV-uninfected participants—contributing 284 baseline HR-HPV infections—were observed for a median of 12 months (interquartile range, 11.5-12.6 months). MC-1 was dominated by Prevotella and MC-2 consisted of a diverse set of anaerobic bacteria ( Finegoldia, Corynebacterium, Peptoniphilus, and Anerococcus). At 12 months, 45% (67 of 150) of MSM had 86 persistent HR-HPV and 55% (83 of 150) cleared all baseline HR-HPV. HPV16 (21%), HPV45 (13%), and HPV51 (12%) were the most persistent. Persistence of any HR-HPV was nonsignificantly higher in MC-1 (odds ratio [OR], 1.6; 95% CI, 0.8 to 3.1). Persistent HPV16 was more abundant in MC-2 versus MC-1 (OR, 3.9; 95% CI, 1.2 to 12.0), whereas HPV45 and HPV51 were similarly distributed across both MCs. Compared with HIV-uninfected, persistence (OR, 1.6; 95% CI, 0.8 to 3.3) and MC-2 membership (OR, 1.3; 95% CI, 0.8 to 2.0) were nonsignificantly higher among HIV-infected participants. CONCLUSION Anal HPV16 has the highest annual persistence and is associated with a low Prevotella anal microbiota, a potentially modifiable cofactor.
Comprehensive Genomic Analysis in NRG Oncology/RTOG 9802: A Phase III Trial of Radiation Versus Radiation Plus Procarbazine, Lomustine (CCNU), and Vincristine in High-Risk Low-Grade Glioma
Authors: Bell Erica H. , Zhang Peixin , Shaw Edward G. , Buckner Jan C. , Barger Geoffrey R. , Bullard Dennis E. , Mehta Minesh P. , Gilbert Mark R. , Brown Paul D. , Stelzer Keith J. , McElroy Joseph P. , Fleming Jessica l. , Timmers Cynthia D. , Becker Aline P. , Salavaggione Andrea L. , Liu Ziyan , Aldape Kenneth , Brachman David G. , Gertler Stanley Z. , Murtha Albert D. , Schultz Christopher J. , Johnson David , Laack Nadia N. , Hunter Grant K. , Crocker Ian R. , Won Minhee , Chakravarti Arnab 
Published: July 2020

PURPOSENRG Oncology/RTOG 9802 (ClinicalTrials.gov Identifier: NCT00003375 ) is a practice-changing study for patients with WHO low-grade glioma (LGG, grade II), as it was the first to demonstrate a survival benefit of adjuvant chemoradiotherapy over radiotherapy. This post hoc study sought to determine the prognostic and predictive impact of the WHO-defined molecular subgroups and corresponding molecular alterations within NRG Oncology/RTOG 9802.METHODSIDH1/2 mutations were determined by immunohistochemistry and/or deep sequencing. A custom Ion AmpliSeq panel was used for mutation analysis. 1p/19q codeletion and MGMT promoter methylation were determined by copy-number arrays and/or Illumina 450K array, respectively. Progression-free survival (PFS) and overall survival (OS) were estimated using the Kaplan-Meier method. Hazard ratios (HRs) were calculated using the Cox proportional hazard model and tested using the log-rank test. Multivariable analyses (MVAs) were performed incorporating treatment and common prognostic factors as covariates.RESULTSOf the eligible patients successfully profiled for the WHO-defined molecular groups (n = 106/251), 26 (24%) were IDH-wild type, 43 (41%) were IDH-mutant/non-codeleted, and 37(35%) were IDH-mutant/codeleted. MVAs demonstrated that WHO subgroup was a significant predictor of PFS after adjustment for clinical variables and treatment. Notably, treatment with postradiation chemotherapy (PCV; procarbazine, lomustine (CCNU), and vincristine) was associated with longer PFS (HR, 0.32; P = .003; HR, 0.13; P < .001) and OS (HR, 0.38; P = .013; HR, 0.21; P = .029) in the IDH-mutant/non-codeleted and IDH-mutant/codeleted subgroups, respectively. In contrast, no significant difference in either PFS or OS was observed with the addition of PCV in the IDH-wild-type subgroup.CONCLUSIONThis study is the first to report the predictive value of the WHO-defined diagnostic classification in a set of uniformly treated patients with LGG in a clinical trial. Importantly, this post hoc analysis supports the notion that patients with IDH-mutant high-risk LGG regardless of codeletion status receive benefit from the addition of PCV.
Usefulness of multidetector computed tomography to differentiate between renal cell carcinoma and oncocytoma. A model validation
Authors: Paño Blanca , Soler Alexandre , Goldman Debra A , Salvador Rafael , Buñesch Laura , Sebastià Carmen , Nicolau Carlos 
Published: July 2020

Objective: The purpose of this study is to validate a multivariable predictive model previously developed to differentiate between renal cell carcinoma (RCC) and oncocytoma using CT parameters. Methods and materials: We included 100 renal lesions with final diagnosis of RCC or oncocytoma studied before surgery with 4-phase multidetector CT (MDCT). We evaluated the characteristics of the tumors and the enhancement patterns at baseline, arterial, nephrographic and excretory MDCT phases. Results: Histopathologically 15 tumors were oncocytomas and 85 RCCs. RCCs were significantly larger (median 4.4 cm vs 2.8 cm, p = 0.006). There were significant differences in nodule attenuation in the excretory phase compared to baseline (median: 31 vs 42, p = 0.015), with RCCs having lower values. Heterogeneous enhancement patterns were also more frequent in RCCs (85.9% vs 60%, p = 0.027). Multivariable analysis showed that the independent predictors of malignancy were the enhancement pattern, with oncocytomas being more homogeneous in the nephrographic phase [Odds Ratio (OR) 0.16 (95% CI 0.03 to 0.75, p = 0.02)], nodule enhancement in the excretory phase compared to baseline, with RCCs showing lower enhancement [OR 0.96 (95% CI 0.93 to 0.99, p = 0.005)], and a size > 4 cm, with RCCs being larger [OR 5.89 (95% CI 1.10 to 31.58), p = 0.038]. Conclusion: The multivariable predictive model previously developed which combines different MDCT parameters, including lesion size > 4 cm, lesion enhancement in the excretory phase compared to baseline and enhancement heterogeneity, can be successfully applied to distinguish RCC from oncocytoma. Advances in knowledge: This study confirms that multiparametric assessment using MDCT (including parameters such as size, homogeneity and enhancement differences between the excretory and the baseline phases) can help distinguish between RCCs and oncocytomas. While it is true that this multiparametric predictive model may not always correctly classify renal tumors such as RCC or oncocytoma, it can be used to determine which patients would benefit from pre-surgical biopsy to confirm that the tumor is in fact an oncocytoma, and thereby avoid unnecessary surgical treatments.
A RESILIÊNCIA EM MERCADOS POPULARES: UMA ANÁLISE NO MERCADO CENTRAL DE FORTALEZA
Authors: Victor Caio , Gerhard Felipe , Menezes Domingos , Peñaloza Verónica 
Published: July 2020

Este estudo objetivou conhecer e descrever a resiliência do Mercado Central de Fortaleza. Realizou-se uma pesquisa de inspiração etnográfica e entrevistas conversacionais com 174 atores presentes no cotidiano desse mercado, analisando, mediante as lentes da resiliência, a construção coletiva e a representação do mercado popular por seus atores. A estratégia metodológica utilizada foi a análise de similitude e a análise prototípica. A intensificação do processo de urbanização, a industrialização e a expansão do setor terciário, especialmente por meio da inserção de comércio varejista mais moderno, transformaram o espaço urbano de Fortaleza. Como consequência, o Mercado Central atravessa um período de crise e estagnação, referente às baixas expectativas dos entrevistados. O trabalho contribuiu para compreensão das expectativas dos comerciantes em relação ao mercado. Sabendo da importância e o valor desse patrimônio histórico cultural para a cidade, o mercado necessita de um processo de revitalização.
Admission patterns and risk factors linked with neonatal mortality: A hospital-based retrospective study
Authors: Al-Momani Mohammed Mahmoud 
Published: July 2020

Objective: This research was conducted to analyze the elements and factors that link with newborn deaths at Neonatal Intensive Care Unit (NICU) of a public teaching hospital in Jordan.
Methods: A retrospective study was conducted by reviewing the medical records of all the neonates admitted to the NICU over a one-year period from 1st of March, 2018 to 28th of February, 2019 at Princess Rahma Pediatric Hospital, Jordan.
Results: Overall, the medical records of 1247 neonates were included in this study. The common causes of admission were sepsis (27.3%), followed by respiratory distress syndrome (RDS) (24.9%) and asphyxia (13.1%). The majority of the admitted neonates survived (91.9%), and the overall mortality rate was 8.1%. According to the cause-specific death rate analysis, RDS was the most common cause of death rate (35.6%), followed by sepsis (27.7%). Logistic regression analysis results show that gestational age, weight of the baby at birth, and the quick clinical assessment (Apgar) within the first five minutes were the strongest predictors of neonatal mortality (P<0.05).
Conclusion: Sepsis, RDS, and asphyxia were the leading causes of morbidity in neonates. These diseases were also responsible for a high rate of mortality. Understanding the cause of morbidity and mortality of neonates admitted at NICU is useful for prioritizing and planning health services, re-allocating resources, and improving the quality of care.
doi: https://doi.org/10.12669/pjms.36.6.2281
How to cite this:Al-Momani MM. Admission patterns and risk factors linked with neonatal mortality: A hospital-based retrospective study. Pak J Med Sci. 2020;36(6):1371-1376. doi: https://doi.org/10.12669/pjms.36.6.2281
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Endometriosis within the sigmoid colon: A rare cause of bowel obstruction
Authors: Long-zhi Zheng , Jian Guo , Wei Lin 
Published: July 2020

Endometriosis is a common gynecological disease, ectopic endometrium can invade any part of the body, usually in the ovary and uterine sacral ligament, while endometriosis invades the intestinal wall to cause intestinal obstruction is very rare, which easily leads to misdiagnosis. In this case report, we present a case of sigmoid endometriosis with bowel obstruction. Pathological examination is the main basis for the diagnosis of intestinal endometriosis, and the comprehensive treatment of surgery and hormonal therapy is an effective method for the treatment of intestinal endometriosis.
doi: https://doi.org/10.12669/pjms.36.6.2525
How to cite this:Long-zhi Z, Jian G, Wei L. Endometriosis within the sigmoid colon: A rare cause of bowel obstruction. Pak J Med Sci. 2020;36(6):1421-1424. doi: https://doi.org/10.12669/pjms.36.6.2525
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Isolation and characterization of a novel Sphingobium yanoikuyae strain variant that uses biohazardous saturated hydrocarbons and aromatic compounds as sole carbon sources
Authors: Mitra Mautusi , Nguyen Kevin Manoap-Anh-Khoa , Box Taylor Wayland , Gilpin Jesse Scott , Hamby Seth Ryan , Berry Taylor Lynne , Duckett Erin Harper 
Published: July 2020

Background: Green micro-alga, Chlamydomonas reinhardtii (a Chlorophyte), can be cultured in the laboratory heterotrophically or photo-heterotrophically in Tris-Phosphate-Acetate (TAP) medium, which contains acetate as the carbon source. Chlamydomonas can convert acetate in the TAP medium to glucose via the glyoxylate cycle, a pathway present in many microbes and higher plants. A novel bacterial strain, CC4533, was isolated from a contaminated TAP agar medium culture plate of a Chlamydomonas wild type strain. In this article, we present our research on the isolation, and biochemical and molecular characterizations of CC4533. Methods: We conducted several microbiological tests and spectrophotometric analyses to biochemically characterize CC4533. The 16S rRNA gene of CC4533 was partially sequenced for taxonomic identification. We monitored the growth of CC4533 on Tris-Phosphate (TP) agar medium (lacks a carbon source) containing different sugars, aromatic compounds and saturated hydrocarbons, to see if CC4533 can use these chemicals as the sole source of carbon. Results: CC4533 is a Gram-negative, non-enteric yellow pigmented, aerobic, mesophilic bacillus. It is alpha-hemolytic and oxidase-positive. CC4533 can ferment glucose, sucrose and lactose, is starch hydrolysis-negative, resistant to penicillin, polymyxin B and chloramphenicol. CC4533 is sensitive to neomycin. Preliminary spectrophotometric analyses indicate that CC4533 produces b-carotenes. NCBI-BLAST analyses of the partial 16S rRNA gene sequence of CC4533 show 99.55% DNA sequence identity to that of Sphingobium yanoikuyae strain PR86 and S. yanoikuyae strain NRB095. CC4533 can use cyclo-chloroalkanes, saturated hydrocarbons present in car motor oil, polyhydroxyalkanoate, and mono- and poly-cyclic aromatic compounds, as sole carbon sources for growth. Conclusions: Taxonomically, CC4533 is very closely related to the alpha-proteobacterium S. yanoikuyae, whose genome has been sequenced. Future research is needed to probe the potential of CC4533 for environmental bioremediation. Whole genome sequencing of CC4533 will confirm if it is a novel strain of S. yanoikuyae or a new Sphingobium species.
Platform Competition with Multihoming on Both Sides: Subsidize or Not?
Authors: Bakos Yannis , Halaburda Hanna 
Published: July 2020

A major result in the study of two-sided platforms is the strategic interdependence between the two sides of the same platform, leading to the implication that a platform can maximize its total profits by subsidizing one of its sides. We show that this result largely depends on assuming that at least one side of the market single-homes. As technology makes joining multiple platforms easier, we increasingly observe that participants on both sides of two-sided platforms multihome. The case of multihoming on both sides is mostly ignored in the literature on competition between two-sided platforms. We help to fill this gap by developing a model for platform competition in a differentiated setting (a Hotelling line), which is similar to other models in the literature but focuses on the case where at least some agents on each side multihome. We show that when both sides in a platform market multihome, the strategic interdependence between the two sides of the same platform will diminish or even disappear. Our analysis suggests that the common strategic advice to subsidize one side in order to maximize total profits may be limited or even incorrect when both sides multihome, which is an important caveat given the increasing prevalence of multihoming in platform markets. This paper was accepted by Joshua Gans, business strategy.
Implementation of a nationwide universal ultrasound screening programme for developmental dysplasia of the neonatal hip in Mongolia
Authors: Ulziibat Munkhtulga , Munkhuu Bayalag , Schmid Raoul , Baumann Thomas , Essig Stefan 
Published: July 2020

Purpose Mongolia is the first Asian country to launch universal ultrasound screening for newborns with developmental dysplasia of the hip (DDH). The aims of this study were to determine the coverage and treatment rate of this programme. Methods Data from birth statistics and ultrasound hip screening from 29 hospitals were retrospectively reviewed (2010 to 2016, pre-nationwide phase; and 2017 to 2019, nationwide programme). DDH was diagnosed using the Graf-technique and treated according to ‘ABCD’, a modified Graf classification (Group A: Graf Type 1, mature; B: 2a, physiologically immature; C: 2c to 3, early DDH; D: 4, dislocated). Group B children were followed with monthly ultrasound. Group C and D children were treated with a flexion and abduction orthosis (Tübingen). Screeners used a web-based platform to upload images for quality surveillance. Results Between 2017 and 2019, 230 079 live births were registered and 176 388 newborns screened. The nationwide screening coverage rate in newborns increased from 73.6% in 2017 to 82.1% in 2019. Group A (148 510 children, 84.2%) was discharged, while Group B (25 820, 14.6%) was followed. Among children in Group B, 284 cases worsened to Group C and were, therefore, treated with a Tübingen orthosis. The remaining 2058 (1.2%) of newborns with DDH were treated with a Tübingen orthosis, including 1999 newborns in Group C and 59 in Group D. Since 2017, a total of 142 860 (81.0%) hip sonograms were uploaded to the platform. Conclusion A simplified diagnostic and therapeutic framework for ultrasound DDH screening for newborns was successfully deployed in Mongolia, a developing country, providing high surveillance coverage and appropriate treatment. Level of evidence: IV
Design and Experimental Analysis of a Stirring Device for a Pneumatic Precision Rice Seed Metering Device
Authors: Xing He , Zang Ying , Wang Man Zai , Luo Wen Xi , Zhang Hua Ming , Ma Xin Yue , Fang Yu Long 
Published: July 2020

HighlightsThe problems of high resistance to seed sucking and the poor stability of seed sucking were solved.A mechanical model was established for seeds in a seed stirring device.The optimum parameters of the seed stirring device were obtained.Seeding precision was improved, providing a reference for the seed sucking process.Abstract. To achieve a goal of precision seeding with 1 to 3 seeds per hill and to solve problems in a pneumatic rice seed metering device, including high resistance to seed sucking, poor stability of seed suction, and low seeding precision, a cylindrical seed stirring device was designed. The design was based on the characteristics of the rice seed flow in the seed suction area. A mechanical model of the rice seed in the seed stirring device was established. The relationships between the seed fluidity and the parameters of the seed stirring device were simulated with EDEM software. The effects of seed fluidity on the seed suction area were analyzed under different seed stirring device parameters. To analyze the influences of different parameters of the seed stirring device on seed stirring and to observe the relationships between different parameters and rice seeds, high-speed photography was used to observe the seed sucking and stirring processes. The super hybrid rice Y-2 You 900 was selected as the test material. The seeding precision was tested at different rotating speeds, negative pressures, and parameters of the seed stirring device. The test results showed that an increase in the diameter and thickness of the seed stirring device was beneficial for increasing the seed absorption rate and reducing the missed seed rate but also increased the rate of multiple-seed sucking and reduced the seeding precision. The optimal parameters of the seed stirring device were a cylinder thickness of 2 mm and a diameter of 5 mm. This study provides a certain reference basis for the seed suction process of a pneumatic seed metering device. Keywords: Agricultural machinery, Precision seeding, Rice sowing, Seed stirring device, Seeder.