bluuebunny/crossref_metadata_2025_split huggingface dataset:
Could age increase the strength of inverse association between ultraviolet B exposure and colorectal cancer?
Authors: Purushothaman Vidya Lakshmi , Cuomo Raphael E , Garland Cedric F , Mackey Tim Ken 
Published: April 2020

Abstract
Background: Vitamin D has been identified as a potential protective factor the development of colorectal cancer (CRC). We expect to see a stronger association of ultraviolet B (UVB) exposure and CRC crude rates with increasing age since chronic vitamin D deficiency leads to sustained molecular changes that increase cancer risk. The DINOMIT (disjunction, initiation, natural selection, overgrowth, metastasis, involution, and transition) model postulates various stages of cancer development due to vitamin D deficiency and the associated latency period. The purpose of this study is to examine this age-dependent inverse relationship globally.Methods: In this ecological study, a series of linear and polynomial regression tests were performed between country specific UVB estimates adjusted for cloud cover and crude incidence rates of CRC for different age groups. Multiple linear regression was used to investigate the association between crude incidence rates of colorectal cancer and UVB estimate adjusting for urbanization, skin pigmentation, smoking, animal consumption, per capita GDP, and life expectancy. Statistical analysis was followed by geospatial visualization by producing choropleth maps.Results: The inverse relationship between UVB exposure and CRC crude rates was stronger in older age groups at the country level. Quadratic curve fitting was preferred, and these models were statistically significant for all age groups. The inverse association between crude incidence rates of CRC and UVB exposure was statistically significant for age groups above 45 years, after controlling for covariates.Conclusion: The age-dependent inverse association between UVB exposure and incidence of colorectal cancer exhibits a greater effect size among older age groups in global analyses. Studying the effect of chronic vitamin D deficiency on colorectal cancer etiology will help in understanding the necessity for population wide screening programs for vitamin D deficiency, especially in regions with inadequate UVB exposure. Further studies are required to assess the need for adequate public health programs such as selective supplementation and food fortification.
The clinical analysis of endoscopic pancreaticobiliary separation in the treatment of occult pancreaticobiliary reflux
Authors: Gang Zhao , Cheng Zhang , Hao Cai , An Xu An , Dong Li Hai , Qi He Chuan , Aliou GARBA SEYDOU , Long Yang Yu 
Published: April 2020

Abstract
Objective To investigate the aetiology of occult pancreaticobiliary reflux (OPBR) and the curative effect of EST in patients with cholecystolithiasis. Methods The clinical data of 47 OPBR patients with cholecystolithiasis from October 2013 to October 2016 were analyzed retrospectively.Results The average gallbladder bile amylase (GBA) of 47 patients was 864 ± 575 U/L. Forty patients underwent endoscopic retrograde cholangiopancreatography (ERCP), among which 26 patients were diagnosed with papillitis, 16 patients with peripapillary diverticulum, 14 patients with nipple overlength, five patients with nipple atrophy, three patients with ampullary calculi and two patients with papillary tumour. Thirty-three patients underwent endoscopic sphincterotomy (EST), after the operation, 16 patients reexamined GBA, in which 15 patients had normal GBA, and the difference of GBA was statistically significant (1161 ± 764 U/L vs 47 ± 17 U/L, t=5.641, P<0.05). After following up of 1 to 4 years, 27 patients without cholecystectomy who underwent EST had no recurrence of calculus, and in 9 patients who did not undergo EST, two patients had a recurrence of calculus. There was a significant difference in the recurrence rate of calculus (χ2=21.340, P<0.05). Conclusion Pancreaticobiliary junction disease is an essential cause of OPBR and cholecystolithiasis formation. EST can reduce the retention of pancreatic reflux juice both in gallbladder and bile duct and can reduce the recurrence rate of cholecystolithiasis after choledochoscopic lithotomy.
The miRNA Complexes Against Coronaviruses COVID-19, SARS-CoV, And MERS-CoV
Authors: Rakhmetullina Aizhan , Ivashchenko Anatoliy , Akimniyazova Aigul , Aisina Dana , Pyrkova Anna 
Published: April 2020

Abstract
Background: In the past twenty years humankind has effected from infection caused by SARS-CoV (severe acute respiratory syndrome), MERS-CoV (Middle East respiratory syndrome) and COVID-19 coronaviruses, which have caused significant harm to human health and resulted in high mortality. The possibility of using miRNA (mRNA-inhibiting RNA) to inhibit infections caused by the coronaviruses COVID-19, SARS-CoV, and MERS-CoV has been shown. Methods: The MirTarget program determines the following characteristics of interaction between miRNAs and messenger RNAs (mRNAs): the start of the miRNA binding site on the mRNA; the locations of the miRNA binding sites in the 3'-untranslated region (3'UTR), 5'-untranslated region (5'UTR), or coding sequence (CDS); the interaction free energy (∆G, kJ/mole); and nucleotide interaction schemes between miRNAs and mRNAs. Results: Using bioinformatics approaches, completely complementary miRNA (cc-miRNA) complexes were predicted to be able to bind and inhibit the translation of coronavirus proteins and the replication of COVID-19, SARS-CoV, and MERS-CoV genomes. For complexes of seven completely complementary miRNA of COVID-19 (cc-miRc), seven completely complementary miRNA of SARS-CoV (cc-miRs), and eight completely complementary miRNA of MERS-CoV (cc-miRm), the interactions with the RNA genomes (gRNAs) of the corresponding coronaviruses was evaluated. The free energy of the interactions of cc-miRNAs with binding sites was significantly higher than the free energy of the interactions with other regions in gRNA, which ensures high selectivity of the binding of cc-miRNAs. Weak binding of cc-miRNAs to the mRNAs of 17508 human genes was shown, which suggests the absence of side effects of the cc-miRNAs in humans. A feature of this method is the simultaneous inhibition of translation and replication by several cc-miRNAs binding from the 5' end to the 3' end of gRNA. Conclusion: The use of several cc-miRNAs to suppress infections allows each of them to be used at a lower concentration to avoid side effects when one cc-miRNA is introduced into humans at a high concentration.
Gamifying Parenting Education Using an App Developed for Pacific and Other New Zealand Families (Play Kindly): Qualitative Study
Authors: Mairs Rebecca A , Bekker Marthinus J , Patolo Tony , Hopkins Sarah A , Cowley-Malcolm Esther T , Perese Lana M , Sundborn Gerhard B , Merry Sally N 
Published: April 2020

Background
Play Kindly is a gamified animated app designed to address common behavioral problems in childhood. The interface is designed to appeal to Pacific people, a population group with a higher risk of developing clinically significant behavioral problems than most other ethnic groups in New Zealand.

Objective
The aim of this study is to explore the opinions of parents and professionals about the acceptability, usability, and content of Play Kindly.

Methods
We used qualitative and Pacific and Māori research methodologies. A total of five focus groups with 45 parents and 12 individual interviews with professionals were conducted. The five focus groups consisted of 2 pan-Pacific groups, 1 Māori group, 1 open group, and 1 group of young Pacific adults or prospective parents. The professionals were from a range of disciplines, and the majority had expertise in early childhood, parenting interventions, or research in this field.

Results
Play Kindly appealed to both parents and professionals. Participants related to the scenarios, which were created in collaboration with a playwright and animator. Although most participants liked the Pacific feel, there was some disagreement about how culturally specific the app should be. A range of issues with usability and gamification techniques were highlighted, likely attributed to the low budget and lack of initial co-design with parents as well as professionals with specific expertise in parenting. A number of parents and professionals felt that the parenting strategies were overly simplified and did not take into account the context in which the behavior occurred. Professionals suggested narrowing the focus of the app to deliver two important parenting messages: playing with your child and positively reinforcing desired behaviors.

Conclusions
Play Kindly is the first culturally adapted parenting app of its kind designed for Pacific parents and other New Zealanders with children 2-5 years of age. This app has potential in Pacific communities where there are limited culturally specific parenting resources. The results of this study will guide improvements of the app prior to testing it in an open trial.
It Is Time to Put Special Tests for Rotator Cuff–Related Shoulder Pain out to Pasture
Authors: Salamh Paul , Lewis Jeremy 
Published: April 2020

Synopsis “Special tests” for rotator cuff–related shoulder pain (RCRSP) have passed their sell-by date. In this Viewpoint, we outline fundamental flaws in the validity of these tests and their proposed ability to accurately identify a pathoanatomical source of pain. The potential harm of these special tests comes in conjunction with imaging findings that are utilized to inform a structural diagnosis or recommend invasive procedures. We offer recommendations for performing a clinical interview and physical examination for people with RCRSP that does not include shoulder orthopaedic tests. J Orthop Sports Phys Ther 2020;50(5):222–225. doi:10.2519/jospt.2020.0606
PENGARUH STRUKTUR MODAL DAN PERTUMBUHAN TERHADAP PROFITABILITAS DAN NILAI PERUSAHAAN (STUDI KASUS PADA PERUSAHAAN OTOMOTIF YANG TERCATAT DI BURSA EFEK INDONESIA)
Authors: Harusi Muhammad Khakani , Ali Muhammad , Sobarsyah Muhammad 
Published: April 2020

Persaingan yang ketat dalam dunia usaha mendorong setiap perusahaan untuk meningkatkan kinerjanya agar tujuan perusahaan dapat tercapai. Perusahaan yang telah go public akan senantiasa berusaha untuk meningkatkan nilai perusahaan, melalui struktur modal, pertumbuhan serta profitabilitas. Penelitian ini bertujuan untuk mengetahui dan menganalisis : pengaruh struktur modal dan pertumbuhan perusahaan terhadap profitabilitas. Pengaruh struktur modal dan pertumbuhan perusahaan terhadap nilai perusahaan. Pengaruh profitabilitas terhadap nilai perusahaan, pengaruh struktur modal terhadap nilai perusahaan dimediasi oleh profitabilitas, serta untuk mengetahui dan menganalisis pengaruh pertumbuhan perusahaan terhadap nilai perusahaan dimediasi oleh profitabilitas. Penelitian ini menggunakan pendekatan kuantitatif. Sedangkan teknik pengumpulan data dengan menggunakan observasi, dan dokumentasi. Teknik analisis data yang digunakan adalah analisis deskriptif, uji asumsi klasik, analisis jalur. Hasil analisis dalam penelitian ini yang menunjukkan bahwa struktur modal (DER) berpengaruh negatif dan signifikan terhadap profitabilitas. Pertumbuhan perusahaan berpengaruh positif dan signifikan terhadap profitabilitas (ROA). Struktur modal berpengaruh negatif terhadap nilai perusahaan. Pertumbuhan perusahaan memberikan pengaruh yang bermakna dalam meningkatkan nilai perusahaan. Profitabilitas (ROA) yang tinggi akan memberikan pengaruh dalam meningkatkan nilai perusahaan. Hasil uji mediasi menunjukkan bahwa profitabilitas dapat memediasi pengaruh struktur modal (DER) terhadap nilai perusahaan. Hal ini dapat dilihat bahwa struktur modal (DER) mempengaruhi profitabilitas (ROA) sehingga berimplikasi terhadap rendahnya nilai perusahaan (PER). Hasil uji mediasi yang menunjukkan bahwa profitabilitas dapat memiliki pengaruh pertumbuhan perusahaan terhadap nilai perusahaan, yang artinya pertumbuhan perusahaan mempengaruhi peningkatan profitabilitas (ROA) yang berimplikasi dalam meningkatkan nilai perusahaan (DER).
Infinite Narratives on Infinite Earths. The Evolution of Modern Superhero Films
Authors: Żaglewski Tomasz 
Published: April 2020

After almost 20 years of a succesful run of superhero films it seems that we are now entering into the fully-developed format of this kind of cinema. Through films like “Avengers: Infinity War”, “Logan” or “Spider-Man: Into the Spider-verse” the general audience all over the world is becoming familiar with strictly comics-based forms and ideas like retcon, crossover or the multiverse paradigm (that serves as a model for ‘infinite’ superhero narratives and limitless iterations of characters). Despite the fact that popular cinema had already introduced some of these elements before – like the crossover aesthetic in Universal Studios’ horrors from the 1930s and 1940s – modern superhero cinematic universes can be seen as much more demanding productions for the viewers in terms of following strongly comic books-based modes of the ‘multiverse-centric’ perception. As a result we can right now observe an emerging process of turning even the non-superheroic popular cinematic features into very ‘comic booky’ narrative patterns. In this article I’m interested in analyzing the most recent cases of superhero cinema by looking at some specific titles as a way of introducing the narrative systems and tools from superhero comics into cinema.
Potensi Pengairan Daerah Irigasi di Kecamatan Mempura Kabupaten Siak Provinsi Riau
Authors: Apriani Widya , Trisep haris Virgo 
Published: April 2020

Kecamatan Mempura merupakan salah satu daerah potensi irigasi yang terletak di Kabupaten Siak, Provinsi Riau. Potensi luas area sekitar 34,6 Ha direncakanan untuk daerah pertanian sawah padi. Evaluasi Kesembangan air perlu diketahui untuk melihat potensi daerah tersebut. Dalam penelitian ini dilakukan analisis ketersediaan air irigasi, analisis kebutuhan air irigasi, analisis keseimbangan air, dan pengoptimalan Mempura. Hasil Evaluasi keseimbangan air menunjukkan bahwa ketersediaan mencukupi kebutuhan kebutuhan air berdasarkan pola tanam eksisting. Kondisi dimana terjadi surplus air pada bulan Januari, April, September hingga Desember. Sedangkan terjadi defisit pada beberapa bulan yaitu Maret, Mei Juni dan Juli. Neraca keseimbangan air menunjukkan bahwa ketersediaan air dalam memenuhi kebutuhan air tanaman padi masih mencukup untuk dimanfaatkan seluruh lahan potensial dengan merencanakan penanaman komoditas padi pada setiap musim tanam menggunakan sistem pemberian air secara serempak. Untuk dapat mengairi sawah, sistem irigasi yang direncanakan adalah sistem pompa.
Optimization of high density long duration transportation of silver carp (Hypophthalmichthys molitrix) and rui (Labeo rohita) fingerlings
Authors: Hasan Mahmud 
Published: April 2020

The effects of density (50, 55 and 60 kg fingerlings/drum of 200 litre) on the mortality and essential water quality variables were assessed for silver carp Hypophthalmichthys molitrix fingerlings in a simulated transport experiment. The second experiment involved the determination of the effects of knowing the optimum loading density 50 kg/drum fingerlings on the mortality and water quality in silver carp advanced fingerlings for standard 8 hours transport simulation. Six hours of simulation duration resulted in less than 1% mortality and 8 hours caused about 6%. Third experiment with highest density 60 kg/drum fingerlings at 500 g/l of advanced rui (Labeo rohita) fingerlings was used for a period of 6 hours since the quality of the transport medium was deteriorated due to regurgitated stomach contents. The fingerlings were unconditioned and fed. Level of immediate mortality was only nearly 3% at 6 hours of simulation duration. This study has clearly demonstrated that the optimum loading of silver carp fingerlings per drum is 50 kg. The minimum concentration of dissolved oxygen (DO) concentration for maximum survival is 2 mg/l for silver carp fingerlings. Silver carp advanced fingerlings can be transported for 8 hours duration by using 2 phenoxyethanol at the concentration of 115 μl/l with oxygen injection. Rui advanced fingerlings can be transported at 60 kg/drum (500 g/l) for 6 hrs duration even if the fingerlings are unconditioned.
Dhaka Univ. J. Biol. Sci. 27(1): 9-16, 2018 (January)
Water quality and potamoplankton of the river Buriganga and Gomti: A comparison
Authors: Bhuiyan Mohammad Azmal Hossain , Khondker Moniruzzaman 
Published: April 2020

The studied section of the river Buriganga besets with urban catchment contained higher values of pH, alkalinity, CO2, conductivity, TDS, SRP, SRS and NO3-N concentration compared to its counterpart, namely a section of the river Gomti having rural catchment characteristics. The mean values for a period of six months for the river Buriganga were 8.34, 1.48 meq/l, 8.49 mg/l, 686 μS/cm, 155.17 mg/l, 493 μg/l, 36.07 mg/l and 810.28 μg/l for pH, alkalinity, CO2, conductivity, TDS, SRP, SRS and NO3-N, respectively. While the same for the river Gomti was 7.86, 1.18 meq/l, 5.42 mg/l, 284.44 μS/cm, 79.91 mg/l, 188.37 μg/l, 26.41 mg/l and 203.99 μg/l, respectively for pH, alkalinity, CO2, conductivity, TDS, SRP, SRS and NO3-N. In the river Gomti, the concentration of DO was better (7.87 mg/l) compared to that of river Buriganga (5.53 mg/l). Because of a hilly origin of the river Gomti and availability of sediments in its water, the underwater light climate was poor compared to the river Buriganga. The Secchi depth recorded for Gomti and Buriganga were 0.26 and 0.54 m, respectively. Both the rivers were found diatom dominant in terms of population but the species prevailed were different. Fragillaria virescens Ralfs was the dominant diatom of the river Buriganga. Its density ranged from 6.5-11.09×105 ind/l which was the highest compared to the population of all other groups of potamoplankton. In Gomti another diatom namely, F. pinnata Ehrenberg was dominant and the density of which ranged from 8.45 - 12.65 × 105 ind/l. Community structure of the potamoplankton revealed 30 species from the river Buriganga and 22 species from Gomti. The study reveals that relatively higher concentration of nutrients prevails in the water of the river course having urban catchment characters compared to the rural ones.
Dhaka Univ. J. Biol. Sci. 27(2): 191-200, 2018 (July)
Psychometric properties of Lock-Wallace short marital adjustment scale (LWSMAT) for Bangladeshi couples
Authors: Khatun Mosammat Nazma , Deeba Farah , Tushar Tanzir Ahmmad 
Published: April 2020

The present study aimed to explore psychometric properties of the Lock- Wallace Short Marital Adjustment Scale to use in the context of Bangladesh. The original scale consisted of 15 items and higher scores on the scale indicate greater marital satisfaction. After attaining agreement on the appropriateness of translated items by judges, item analysis was done using 318 clinical and nonclinical samples. The Cronbach’s Alpha and split-half reliability of the adapted scale was 0.92 and 0.95, respectively. The test-retest correlation was also found to be significant (r = 0.95, α = 0.01). Construct validity was measured by computing discriminant validity (F = 38.88, α < 0.001) between the clinical and non-clinical sample. Convergent validity was also ensured by measuring correlation(r = 0.72, α = 0.01) between Lock-Wallace scale and Spanier's Dyadic Adjustment Scale. It is suggested that the scale be used in Bangladeshi context considering that the item may incur low score for couples.
Dhaka Univ. J. Biol. Sci. 28(2): 159-165, 2019 (July)
Diversity of Angiosperm Flora of Kuakata National Park, Patuakhali District, Bangladesh
Authors: Rahaman M Azizar , Rahman Md Azizur , Uddin Mohammad Zashim 
Published: April 2020

The article mainly highlights the angiosperm diversity of Kuakata National Park (KNP) of Patuakhali district. Angiosperm diversity assessment in the park was conducted in between 2015 and 2016. A total of 265 plant species belonging to 75 families and 204 genera was identified from this National Park. Tree species of the park are represented by 89, shrubs by 45, herbs by 94, climbers by 31 and epiphytes by 6 species. In Magnoliopsida (dicots), Fabaceae is the largest family represented by 14 species, whereas in Liliopsida (monocots), Poaceae is the largest family represented by 13 species. The plant species recorded from the National Park were distributed in different habitats and maximum species were recorded in plantation areas(108) followed by homesteads (61), cultivated land(38), roadsides (35) and mangrove areas (23).The study has reported the presence of medicinal plants, wildlife supporting plants, exotics and invasive plants and rare plants in park. The presence of edible species in the National Park is very rare. The introduction of exotics species into the National Park has been accepted. As the presence of exotics in park, local flora will be faced great challenges in future for their existence. This article also focused conservation values, management concerns and some actions for conservation of angiosperm diversity in the National Park. The present angiosperm diversity assessment in the park is very preliminary and based on this sound conclusion cannot be made yet.
Asiat. Soc. Bangladesh, Sci. 43(2): 143-159, December 2017
PENGARUH LATIHAN SIRKUIT TERHADAP VO₂ MAX PADA KOMUNITAS BERLARI RUNJANI KOTA MATARAM TAHUN 2018
Authors: Arief As'ad Lalu Muhammad , Ruqayyah Siti , Nauval Muhammad 
Published: April 2020

Latar Belakang: Kebugaran jasmani merupakan salah satu aspek fisik dari kesegaran menyeluruh (total fitness). Latihan Sirkuit adalah suatu program latihan terdiri dari beberapa stasiun dan di setiap stasiun seorang atlet melakukan jenis latihan yang telah ditentukan. VO₂ Max adalah jumlah maksimal oksigen yang dapat dikonsumsi selama aktivitas fisik yang intensif sampai akhirnya terjadi kelelahan. Pengukurannya dapat digunakan untuk menganalisis efek dari suatu program latihan fisik. Tujuan: Mengetahui pengaruh latihan sirkuit terhadap VO₂ Max pada Komunitas Berlari RUNJANI Kota Mataram. Metode: Penelitian ini menggunakan metode pre eksperimental dengan desain penelitian one group pre test post test design. Teknik pengambilan sampel dilakukan secara purposive sampling dengan total sampel sebanyak 30 subjek. Data yang telah terkumpul diolah menggunakan program SPSS. Hasil: Berdasarkan nilai VO2 Max pre-test didapatkan 5 subjek kategori terlatih (16.6%), 2 subjek kategori baik sekali (6.6%), 8 subjek kategori baik (26.6%), dan 10 subjek kategori sedang (33.3%). Pada nilai VO2 Max post-test didapatkan 6 subjek kategori terlatih (20%), 1 subjek kategori baik sekali (3.33%), 14 subjek kategori baik (46.6%), dan 9 subjek kategori sedang (30%). Standard deviasi sebelum perlakuan sebesar 1,62095 dan setelah perlakuan sebesar 1,83366 dengan hasil p-value sebesar 0,1 (p < 0,05), berarti terdapat pengaruh yang signifikan antara latihan sirkuit degan nilai VO₂ Max.
GENERAL ANASTESI FACE MASK (GA FM) PADA PASIEN COMBUTIO GRADE II A
Authors: Darsana I Dewa Gede Oka 
Published: April 2020

Teknik general anestesi inhalasi yang dilakukan dengan jalan memberikan kombinasi obat anestesi inhalasi yang berupa gas dan atau cairan yang mudah menguap melalui alat atau mesin anestesi langsung ke udara inspirasi. Pada pasien combutio yang dilakukan tindakan debridement yang singkat (0,5 jam – 1 jam) tanpa membuka rongga perut, keadaan umum pasien cukup baik (status fisik ASA I atau ASA II) dengan jenis operasi meliputi operasi kecil dan waktu pasien akan kembali sadar penuh dalam waktu 15 menit dan tidak sadar yang berlangsung diatas 15 menit dianggap prolonged.
Tujuan dari laporan kasus ini adalah mendiskusikan penatalaksanaan anastesi dengan menggunakan Face Mask (Sungkup Muka). Face Mask dapat membantu mengubah kondisi pasien yang tidak bisa diventilasi menjadi bisa diventilasi.
Pasien seorang anak laki-laki usia 3 tahun datang sadar ke RSU Bangli oleh orangtua pasien dengan keluhan nyeri pada luka bakar sejak 4 hari yang lalu. Pasien dibawa ke rumah sakit pada tanggal 26 juli 2019. Pasien memilikiDiagnosis pre operatif Combutio grade II A, dengan status operatif ASA I.