bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Vietnamese Organizations Perceive the Use of Social Media in Crisis Communication
Authors: Ly-Le Tuong-Minh 
Published: November 2019

<p>Social media has proliferated into the everyday life of Vietnamese people. As a result, in the past years, Vietnam has seen many organizational crises that started on this platform. Social media has proven to be able to foster crises, thanks to open platforms that allow for relatively free discussion among strangers with common interests. Nonetheless, Vietnamese organizations have often ignored or underutilized these channels in their crisis communication efforts. Organizations prioritize using traditional media in their crisis communication efforts and paid little to no attention to social media outlets, even if the crisis had started on social media channels. Through a survey with experienced Vietnamese PR practitioners, this research aims to understand this trend of crisis management and explore the perception of Vietnamese organizations toward the use of social media in crisis communication.</p><p><em><strong>Bahasa Indonesia <em><strong>Abstrak</strong></em></strong>: Media sosial telah menjamur ke dalam kehidupan sehari-hari rakyat di Vietnam. Akibatnya, dalam beberapa tahun terakhir, Vietnam telah melihat banyak krisis organisasi yang dimulai pada platform ini. Media sosial telah terbukti mampu menumbuhkan krisis, berkat platform terbuka yang memungkinkan diskusi bebas untuk kepentingan bersama. Meskipun demikian, organisasi di Vietnam sering mengabaikan atau kurang memanfaatkan saluran-saluran ini dalam upaya krisis komunikasi yang mereka alami. Organisasi lebih memprioritaskan menggunakan media tradisional dalam upaya menanggulangi krisis komunikasi mereka dan sedikit memberikan perhatian kepada outlet media sosial, bahkan jika krisis telah dimulai pada saluran media sosial. Melalui survei yang dilakukan oleh praktisi PR di Vietnam yang berpengalaman, penelitian ini bertujuan untuk memahami tren manajemen krisis ini dan mengeksplorasi persepsi organisasi di Vietnam terhadap penggunaan media sosial dalam komunikasi krisis.</em></p><div id="gtx-trans" style="position: absolute; left: -32px; top: 211px;"> </div>
Ínsula Barataria, número 85, 2017
Authors: Di Laura Giancarla 
Published: November 2019

Esta nueva entrega de la revista de literatura y cultura Ínsula Barataria combina estudios críticos y académicos con textos creativos, que proyectan visiones de nuevos y reconocidos investigadores y autores. Innovandomediante el surgimiento de distintas partes, la revista se compone de siete secciones.
Comparison of outcomes between intravitreal ranibizumab and intravitreal aflibercept for diabetic macular edema with “Treat-and-Extend” regimen
Authors: Sugimoto Masahiko , Chujo Shinichiro , Sasaki Taku , Ichio Atsushi , Miyata Ryohei , Matsubara Hisashi , Kondo Mineo 
Published: November 2019

Abstract
Background To compare the effectiveness of intravitreal ranibizumab (IVR) and aflibercept (IVA) with the Treat-and-Extend (TAE) regimen for diabetic macular edema (DME).Patients and methods Thirteen eyes received an intravitreal injection of 0.5 mg ranibizumab (mean age, 70.9±6.0 years) and 13 eyes received 2 mg aflibercept (65.9±8.6 years). After 3 consecutive monthly injections, they received additional injections with the TAE regimen. The changes in the best-corrected visual acuity (BCVA), CRT, and total number of injections were compared.Results No significant differences were detected in the baseline demographics. The BCVA was significantly improved for both groups; 0.31±0.19 to 0.10±0.12 logMAR units for IVR and 0.41±0.19 to 0.16±0.28 logMAR units for IVA at 24 months ( P <0.01). The CRT was significantly reduced in both groups; 440.9±69.3 to 307.5±66.4 μm for IVR and 473.9±71.5 to 317.8±71.2 μm for IVA at 24 months ( P <0.01). No significant differences were detected in the improvements of the BCVA and reduction in the CRT between them. The total number injections were significant fewer for the IVA group (11.0±1.2) than the IVR group (12.0±1.0) at 24 months ( P =0.02).Conclusion The results showed that the TAE regimen was effective. The IVA group required fewer injections to attain the same improvements.
The etiology and prognosis of canalicular lacerations repair using canalicular anastomosis combined with bicanalicular stent intubation
Authors: Guo Tao , Qin Xiuhong , Ji Jiali , Lu Yang , Xu Li , Wang Hongwei , Xiao Caiwen , Zhang Zhenzhen 
Published: November 2019

Abstract
Purpose: To evaluate the etiology of lacrimal canalicular lacerations and explore possible risk factors influencing prognosis. Methods: A total of 142 patients (142 eyes) with lacrimal canalicular lacerations were reviewed and surgically repaired between March 2017 and March 2018. The analyzed data contained demographic information, the type of trauma, injury locations, associated additional ocular injuries and surgerical outcomes at follow-up. The main outcome measures were anatomic success, functional success, and the complication of surgery. Results: The mean patient age was 42.07years(ranging from 1-75 years) and 112 (78.87%) were men. Upper and lower canalicular lacerations were found in 14 (9.86%) and 112 patients (78.87%), respectively. Electromobile accidents were the leading cause of injury with 76 patients (53.52%). There were 100 (70.42%) patients who had lid laceration without tarsal plate fracture and 42 (29.58%) patients who had lid laceration with tarsal plate fracture. Functional reconstruction failure rates were higher in patients with indirect injuries, lid laceration with tarsal plate fracture, and with laceration punctum crack( P <0.05). Surgical Complications were detected in the form of lacrimal punctum ectropion in 3 (2.11%) patients, lacrimal punctum crack in 2 (1.41%) patients, stent extrusion and loss in 2 (1.41%) patients. Conclusions: Electromobile accidents have become the leading cause of injury instead of the motor vehicle accidents because of changes in lifestyle. Silicone intubation was most commonly used in surgery with high anatomic success. The indirect injuries, lid laceration with tarsal plate fracture and with lacrimal punctum crack, were significantly more likely to lead to a poor prognosis, as comfirmed by the lower functional success rate of surgery. Keywords: Canalicular lacerations; etiology; prognosis; epiphora; silicone tube intubation
The Results of Meniscal Allograft Transplantation Surgery: What is Success?
Authors: Searle Henry Kelvin Christopher , Asopa Vipin , Coleman Simon , McDermott Ian 
Published: November 2019

Abstract
Background : Meniscal allograft transplantation (MAT) may improve symptoms and function, and limit premature knee degeneration in patients under 50 years with symptomatic meniscal loss. The aim of this retrospective study was to examine patient outcomes after MAT and to explore the potential definitions of ‘success' or ‘failure’.
Methods : 60 patients who underwent MAT between 2008-2014, aged 18-50 were identified. Six validated outcome measures for knee pathologies, patient satisfaction and return to sport were incorporated into a questionnaire. Surgical failure (removal of most/all the graft, revision MAT or conversion to arthroplasty), clinical failure (Lysholm <65), complication rates (surgical failure plus repeat arthroscopy for secondary allograft tears) and whether patients would have the procedure again were recorded. Statistical analysis included descriptive statistics, with patient-reported outcome measures reported as median and range. A binomial logistic regression was performed to assess factors contributing to failure.
Results : 43 patients (72%) responded, mean age 35.6 (±7.5). 72% required concomitant procedures, and 44% had Outerbridge III or IV chondral damage. The complication rate was 21% (9). At mean follow-up of 3 (±1.9) years, 9% (4) were surgical failures and 21% (9) were clinical failures. Half of those patients considered a failure stated they would undergo MAT again. In the 74% (32) reporting they would undergo MAT again, median KOOS, IKDC and Lysholm scores were 82.1, 62.1 and 88, compared to 62.2, 48.5 and 64 in patients who said they would not. None of the risk factors significantly contributed to surgical or clinical failure, although female gender and number of concomitant procedures were nearly significant. Following MAT, 40% were dissatisfied with type/level of sport achieved, but only 14% would not consider MAT again.
Conclusions: None of the risk factors examined were linked to surgical or clinical failure. Whilst less favourable outcomes are seen with Outerbridge Grade IV, these patients should not be excluded from potential MAT. Inability to return to sport is not associated with failure since 73% of these patients would undergo MAT again. The disparity between ‘clinical failure’ and ‘surgical failure’ means these terms may need re-defining using a bespoke MAT scoring system.
Identification of genes universally differentially expressed in gastric cancer
Authors: Yan Haidan , Shi Yidan , Zhang Jiahui , Chen Haifeng , Guan Qingzhou , He Jun , Li Meifeng , Guo Zheng , Li Ping 
Published: November 2019

Abstract
Background Due to the remarkable heterogeneity of gastric cancer (GC), differentially expressed genes (DEGs) identified at the population-level by case-control comparison cannot afford dysregulation frequency of each DEG in GC. Methods Firstly, the individual-level DEGs were identified for 1,090 GC tissues without paired normal tissues by the RankComp method. Secondly, we directly compared the gene expression in a cancer tissue with its paired normal tissue to identify individual-level DEGs for 448 paired cancer-normal gastric tissues. Results We found 25 DEGs dysregulated not only in more than 90% of 1,090 GC tissues, but also in more than 90% of 448 GC tissues with paired normal tissues. The 25 genes were defined as universal DEGs for GC which were further validated in our additionally measured 24 paired cancer-normal gastric tissues. Among the universal DEGs, four up-regulation genes ( BGN , E2F3 , PLAU and SPP1 ) and one down-regulation gene ( UBL3 ) were found to be cancer genes documented in the COSMIC or F-Census database. By analyzing protein-protein interaction network, we found 12 universal up-regulation genes and their 284 direct neighbor genes were significantly enriched with cancer genes and key biological pathways related to cancer, such as MAPK signaling pathway, Cell cycle and Focal adhesion. The 13 universal down-regulation genes and 16 direct neighbor genes were also significantly enriched with cancer genes and gastric acid secretion related pathway. Conclusion These universal DEGs may be of special importance for GC diagnosis and treatment targets, and can help to study the molecular mechanism of GC.
Comparison of gastric emptying time after the ingestion of whisky with isocalorically-adjusted glucose solution
Authors: Okabe Tadashi , Terashima Hideo , Sakamoto Atsuhiro 
Published: November 2019

Abstract
Background The gastric emptying of alcoholic beverages remains unclear because the current preoperative fasting guidelines state that clear fluids do not include alcohol, which has led to no information being available on the gastric emptying of alcoholic beverages, and inconsistent findings from previous studies. We demonstrated that liquid gastric emptying mainly depended on energy content, regardless of compositional differences. Therefore, we performed the present study to compare gastric emptying times between whisky mixed with water and sugar water with uniform energy contents and volumes. Methods As a crossover study, 10 healthy male volunteers ingested one of 3 test solutions with a uniform volume of 150 ml, i.e., whisky with water-containing whisky 30 ml (67 kcal), sugar water containing glucose 16.8 g (67 kcal), and water (0 kcal), and the gastric emptying time of each beverage was then assessed by ultrasound measurements of the gastric antral cross-sectional area. Results The gastric emptying pattern of whisky with water was faster than that of isocaloric sugar water, but slower than that of water. Each antral cross-sectional area 20, 30, and 40 min after the ingestion of sugar water was significantly higher than that of whisky with water. Antral cross-sectional areas 10 and 20 min after the ingestion of water were significantly lower than those of whisky with water. Conclusions The results of our study suggested that the gastric emptying time of whisky would be shorter than that of isocaloric glucose solution. Unlike the other beverages, the gastric emptying time of alcohol drinks does not purely depend on the energy content because alcohol itself has no calorie before absorption. The liquid gastric emptying of whisky will theoretically have the similar pattern to that of a calorie-free beverage; however, a slower rate than that of water was observed. Further investigations on the factors contributing to this delay are needed.
Expression of tumor pyruvate kinase M2 isoform in plasma and stool of patients with colorectal cancer or adenomatous polyps
Authors: Rigi Farideh , Jannatabad Aliakbar , Izanloo Azra , Roshanravan Reza , Hashemian Hamid Reza , Kerachian Moahammad Amin 
Published: November 2019

Abstract
Background: Tumor pyruvate kinase M2 isoform (tM2-PK), which is an isoform of PK-glycolytic enzyme and appears on the surface of cancerous proliferating cells, has been used as a diagnostic biomarker for colorectal cancer (CRC). The aim of this study was to evaluate the tM2-PK measurement test for the diagnosis of CRCs and adenomatous polyps in plasma and stool samples in an Iranian population.
Methods: In this prospective study, a total of 226 stool and 178 plasma samples were received from patients referred to colonoscopy units. tM2-PK enzyme was measured using two separate ScheBo-Biotech-AG ELISA kits for stool and plasma samples.
Results: At the cut-off value of 4 U/ml, in tumor group, the sensitivity of fecal tM2-PK test was 100% and the specificity was 68%, and in polyp group, the sensitivity and specificity were 87% and 68%, respectively. At the cut-off value of 15 U/ml in tumor group, the sensitivity of plasma tM2-PK test was 98% and specificity was 74% and in polyp group the sensitivity and specificity were 98% and 74%, respectively. Based on our results, a cut-off range of 4.8-8 U/ml and >8 U/ml could be used to detect polyp and tumor in stool samples, respectively. Similarly, a cut-off range of 19-25 U/ml and >25 U/ml is recommended in plasma samples for polyp and tumor detection, respectively.
Conclusions: This study revealed a high specificity and sensitivity of tM2-PK test for stool and plasma samples in patients with CRC and polyps suggesting it as a non-invasive assay to diagnose CRC and adenomatous polyps.
Changes in the health inequalities for diabetes among middle-aged and elderly people in China from 2011 to 2015
Authors: Cao Guizhen , Cui Zhizhen , Ma Qinghua , Wang Congju , Xu Yong , Sun Hongpeng , Ma Yana 
Published: November 2019

Abstract
Objective The purpose of this paper is to measure income-related health inequality among middle-aged and elderly patients with diabetes in China from 2011 to 2015 and to determine its causes. Methods The data for this study were obtained from the China Health and Retirement Longitudinal Study that was carried out in 2011, 2013 and 2015. In total, 48519 Chinese middle-aged and elderly patients were included (15457 in 2011, 16576 in 2013 and 16486 in 2015). A principal component analysis was performed to measure asset-based economic status. The concentration index was used to measure income-related inequality in patients with diabetes. Additionally, we decomposed the concentration index to identify factors that explained wealth-related inequality in patients with diabetes. Results The prevalence of self-reported diabetes among middle-aged and elderly Chinese adults was 5.61%, 7.49% and 8.99% in 2011, 2013 and 2015, respectively. The concentration indices and 95% confidence intervals for diabetes were 0.1359 (0.0525-0.0597), 0.1207 (0.0709-0.0789), 0.1021 (0.0855-0.0942) in 2011, 2013, and 2015, respectively, which are indicative of inequality that favors the rich. The decomposition of the concentration index showed that urban location (39.38%), BMI (31.16%), education level (7.28%), and region (6.09%) had positive contributions to the measured inequality in diabetes in China in 2015. Age (-29.93%) had a negative contribution to inequality. Conclusions The findings confirm a health inequality in diabetes that favor the rich. Furthermore, the inequality declined from 2011 to 2015. We suggest that policy and intervention strategies should be developed to alleviate this health inequality, such as establishing an integrated urban-rural medical insurance scheme and promoting health education programs.
Inhibition of JAK2/STAT3/SOCS3 Signaling Attenuates Atherosclerosis in Rabbit
Authors: Yang Xilan , Jia Jian , Yu Zhen , Duanmu Zheng , He Huiwei , Chen Sen , Qu Chen 
Published: November 2019

Abstract
Background : Previous studies have indicated that the JAK/STAT signaling pathway is involved in modulating arterial adventitia inﬂammation response. In this study, we designed experiment to further investigate the effect of JAK2/STAT3/SOCS3 signaling in rabbit atherosclerosis process. Methods : Atherosclerosis was induced in the abdominal arteries of rabbits by atherogenic diet and endothelial damage. At the same time, animals were received either no treatment or ruxolitinib and killed after 12 weeks. Results : H&E staining and CT scan analysis showed that rabbit atherosclerosis model was constructed successfully. Ruxolitinib, an inhibitor of the Janus kinase 2 (JAK2), substantially decreased the area of atherosclerotic plaques in rabbits treated with high fat diet and balloon injury of the aorta. Moreover, ruxolitinib substantially decreased IL-6 and TNF-α, but increased IL-10 and IL-17 levels in plasma of atherosclerotic rabbits. Additionally, ruxolitinib reduced TC and TG contents and AIP, while enhanced HDL-C level in rabbit plasma. Furthermore, we found that JAK2 and STAT3 phosphorylation were upregulated in rabbits with atherosclerosis when compared with that of the control group, and furthermore the expression of SOCS3 was also increased due to the activation of JAK2 and STAT3, while ruxolitinib inactivated JAK2 and STAT3 pathway and decreased SOCS3 expression. Conclusion : Taken together, inhibiting the JAK2/STAT3/SOCS3 signaling pathway may be a novel method for the clinical treatment of artery atherosclerosis.
Effect of different contrast administration protocols on contrast enhancement and image quality in CT scan
Authors: Ibrahim Noor Ruhaya , Karim Noor Khairiah A. , Shuaib Ibrahim Lutfi , Osman Noor Diyana , Hashim Salwah , Fang Phuah Hooi 
Published: November 2019

Abstract
Objective The aim of this study is to compare the effect of different contrast administration protocols practiced in Advanced Medical and Dental Institute, Universiti Sains Malaysia (Group A) and Hospital Pulau Pinang, Malaysia (Group B), on contrast enhancement and image quality in computed tomography scan. The two protocols were fixed time delay (FTD) with fixed volume (FV), and automatic bolus tracking (ABT) with weight based volume (WBV) contrast administration. Quantification of contrast enhancement’s magnitude in four different anatomical structures was measured in Hounsfield Unit (HU) and based on 5-point scale (1=poor, 5=excellent), the images were rated qualitatively.Results Mean enhancement values of all structures in Group B was higher compared to Group A (p = < 0.001). Mean of quality rating between the two groups was statistically not significant (p = 0.185). There was a weak correlation between HU values and administered contrast volume (r = 0.152). It can be concluded that FTD with FV protocol is non inferior to ABT with WBV protocol as it yielded higher degree of contrast enhancement. There was no significant difference between the two protocols in term of qualitative assessment although ABT with WBV protocol had higher mean grading in image quality.
Gestational malaria in Kisangani : Efficacy of Mefloquine vs Sulfadoxine-Pyrimethamine in Intermittent Preventive Treatment : A Study Protocol for a randomized controlled clinical trial
Authors: Noël Labama Otuli , Nguma Bosenge , Mike-Antoine Maindo Alongo , Gédéon Katenga Bosunga , Joris Losimba Likwela , Albert Ahuka Ona Longombe , Roland Marini Ndjang’eing’a , Jean-Pascal Manga Okenge 
Published: November 2019

Abstract
Background : In order to reduce malaria-related morbidity and mortality during pregnancy, WHO recommends :
Insecticide-treated mosquito nets,

Intermittent Preventive Treatment of malaria in pregnancy,

Prompt and effective case management.

Nevertheless, several cases of resistance to Sulfadoxine-Pyrimethamine, used in intermittent preventive treatment, and to Chloroquine are reported in sub-Saharan Africa and in the Democratic Republic of the Congo. The prevalence of malaria among pregnant women remains high in Africa in general, and in the Democratic Republic of Congo in particular. This issue leads us to conduct this study, which aims at proposing an alternative to SP for preventing malaria in pregnant women.
Materials and methods : From June 1 to October 31, 2019, we enrolled pregnant women from five health facilities in Kisangani for randomized, single-blind controlled clinical trials to compare the efficacy of two intermittent preventive treatment regimens in Kisangani pregnant women, selected before 18 th weeks of amenorrhea. The first regimen consists of 4 doses of Sulfadoxine-Pyrimethamine starting at the selection time and spaced at least 4 weeks during pregnancy. Each dose is made of 3 tablets of 525 mg Sulfadoxine-Pyrimethamine. The second regimen consists of 2 doses of Mefloquine during pregnancy. The first dose is taken at the selection time and the second dose between the 28 th and 32 nd weeks of amenorrhea. Each dose is made of 3 tablets of 250 mg Mefloquine. The efficacy criteria for these two regimens are placental malaria parasitemia, low birth weight of newborn and maternal anemia at delivery. The safety criterion was the occurrence of major side effects.
Discussion : There are not enough randomized clinical trials assessing the efficacy of Mefloquine for the intermittent preventive treatment of malaria in African pregnant women, hence the recommendation for clinical trials. The present study is the only one that conducts such assessment in a hyper-endemic area with resistance to Sulfadoxine-Pyrimethamine and Chloroquine. The findings are therefore intended to promote the use of Mefloquine as the best alternative to Sulfadoxine-Pyrimethamine in the intermittent preventive treatment of malaria.
Clinical trial registration : PACTR201905899965726.
Key words : Intermittent preventive treatment, efficacy, safety, Mefloquine, Sulfadoxine-Pyrimethamine, Kisangani.