bluuebunny/crossref_metadata_2025_split huggingface dataset:
11-yr of coral community dynamics in reefs around Dahab (Gulf of Aqaba, Red Sea): the collapse of urchins and rise of macroalgae and cyanobacterial mats
Authors: Reverter Miriam , Jackson Matthew , Daraghmeh Nauras , von Mach Christian , Milton Nina 
Published: July 2020

AbstractCorals from the Gulf of Aqaba (northern Red Sea) are resilient to high temperatures and therefore this region is regarded as globally important for reef conservation. However, long-term dynamics of coral reef assemblages from the Gulf of Aqaba remain largely understudied. In this study, we analysed the change in benthic, fish and invertebrate assemblages of reefs around Dahab (South Sinai, Egypt) between 2009 and 2019. We also studied the individual trajectories of coral reef benthic categories, key invertebrate and fish species and their relationship. As site emerged as the main factor explaining the variability in coral reef communities, we identified three clusters of sites with similar assemblages. Both benthic, fish and invertebrate assemblages changed considerably at the three site clusters between 2009 and 2019. We found significant increases in fleshy macroalgae (~ 6 to 15%) and cyanobacterial mats (~ 6 to 12%) in all site clusters. Although not observing a significant reduction of hard coral cover, both macroalgae mat cover and cyanobacterial mat cover were significantly negatively related to hard coral cover and hard coral disease. Soft coral cover (mainly corals from the Xeniidae family) decreased significantly in two of the site clusters, their cover being negatively related to macroalgal and cyanobacterial cover. Significant declines in grazer urchins were observed at all site clusters, and a strong negative relationship was found with macroalgae and cyanobacterial mats cover, suggesting urchin decline as one of the main drivers behind algal increases. Different site clusters had different fish trajectories (butterflyfish, parrotfish, surgeonfish and predators), with only damselfish densities significantly decreasing at all sites. A significant decrease in damselfish densities was related to increases in cyanobacterial mats. These findings suggest that if macroalgae and cyanobacteria continue to increase, Dahab coral reefs could undergo degradation, and therefore, more studies are needed to elucidate the drivers behind these algal increases.
Granular Leidenfrost effect in microgravity
Authors: Torres Menéndez Harol , Sack Achim , Pöschel Thorsten 
Published: July 2020

AbstractWhen a container filled with granular material is subjected to vertical vibration in the presence of gravity, under certain conditions a non-monotonous density profile can be observed. This effect which is characteristic for dissipative granular gases, was termed “floating cluster regime” or “granular Leidenfrost effect”. Here, we study the behavior of vibro-agitated granular matter in the absence of gravity and identify a corresponding stationary state of the granulate, that is, we provide experimental evidence of the granular Leidenfrost effect under conditions of weightlessness.
A multiple inflated negative binomial hurdle regression model: analysis of the Italians’ tourism behaviour during the Great Recession
Authors: Bocci Chiara , Grassini Laura , Rocco Emilia 
Published: July 2020

AbstractWe analyse tourism behaviour of Italian residents in the period covering the 2008 Great Recession. Using the Trips of Italian Residents in Italy and Abroad quarterly survey, carried out by the Italian National Institute of Statistics, we investigate whether and how the economic recession has affected the total number of overnight stays. The response variable is the result of a two-stage decision process: first we choose to take a holiday, then for how long. Moreover, since the number of overnight stays is typically concentrated on specific lengths (week-end, week, fortnight) we observe multiple peculiar spikes in its distribution. To take into account these two distinctive characteristics, we generalise the usual hurdle regression model by specifying a multiple inflated truncated negative binomial distribution for the positive responses. Results show that the economic recession impacted negatively on both components of the decision process and that, by controlling for the inflated nature of the response variable’s distribution, the proposed formulation provides a better representation of the Italians’ tourism behaviour in comparison with non-inflated hurdle models. Given this, we believe that our model can be a useful tool for policy makers who are trying to forecast the effects of new targeted policies to support tourism economy.
Structuring of tactile sensory information for category formation in robotics palpation
Authors: Scimeca Luca , Maiolino Perla , Bray Ed , Iida Fumiya 
Published: July 2020

AbstractThis paper proposes a framework to investigate the influence of physical interactions to sensory information, during robotic palpation. We embed a capacitive tactile sensor on a robotic arm to probe a soft phantom and detect and classify hard inclusions within it. A combination of PCA and K-Means clustering is used to: first, reduce the dimensionality of the spatiotemporal data obtained through the probing of each area in the phantom; second categorize the re-encoded data into a given number of categories. Results show that appropriate probing interactions can be useful in compensating for the quality of the data, or lack thereof. Finally, we test the proposed framework on a palpation scenario where a Support Vector Machine classifier is trained to discriminate amongst different types of hard inclusions. We show the proposed framework is capable of predicting the best-performing motion strategy, as well as the relative classification performance of the SVM classifier, solely based on unsupervised cluster analysis methods.
Molecular epidemiology and diagnostics of KRAS mutations in human cancer
Authors: Timar Jozsef , Kashofer Karl 
Published: July 2020

AbstractRAS mutation is the most frequent oncogenic alteration in human cancers. KRAS is the most frequently mutated followed by NRAS. The emblematic KRAS mutant cancers are pancreatic, colorectal, lung adenocarcinomas and urogenital cancers. KRAS mutation frequencies are relatively stable worldwide in various cancer types with the one exception of lung adenocarcinoma. The frequencies of KRAS variant alleles appears cancer type specific, reflecting the various carcinogenic processes. In addition to point mutation KRAS, allelic imbalances are also frequent in human cancers leading to the predominance of a mutant allele. KRAS mutant cancers are characterized by typical, cancer-type-specific co-occurring mutations and distinct gene expression signatures. The heterogeneity of KRAS mutant primary cancers is significant, affecting the variant allele frequency, which could lead to unpredictable branching development in metastases. Selection of minute mutant subclones in the primary tumors or metastases during target therapies can also occur frequently in lung or colorectal cancers leading to acquired resistance. Ultrahigh sensitivity techniques are now routinely available for diagnostic purposes, but the proper determination of mutant allele frequency of KRAS in the primary or metastatic tissues may have larger clinical significance.
Cognitive-Behavioral Therapy for Envy
Authors: Leahy Robert L. 
Published: July 2020

AbstractEnvy is a ubiquitous social emotion often associated with depression, hostility and shame. Often confused with jealousy which involves the fear or anger that a primary relationship is threatened by a third party, envy is an emotion focused on threats to status such that another person’s “gain” is viewed as a “loss” for the self. There is very little in the cognitive behavioral literature on the nature and treatment of envy. In this article I outline the research on the nature of envy, the evolutionary model of envy, the relevance of an integrative CBT model that draws on Beck’s Generic Cognitive Model and Emotional Schema Therapy, and the implications for case conceptualization and treatment.
Assessment and management of effects of large hydropower projects on aquatic ecosystems in British Columbia, Canada
Authors: Bradford Michael J. 
Published: July 2020

AbstractMost of the hydropower generated in Canada’s western province of British Columbia is generated by a small number of large storage or diversion projects that impound large rivers. All but one were built between 1950 and 1985; a period when environmental considerations for large projects were evolving to present-day social, political and regulatory standards. Large projects result in ecosystem transformations; river valleys are converted to reservoirs, and the release of water for power generation results in highly altered flow regimes downstream of dams. I describe the effects of three projects on aquatic ecosystems and measures that have been taken over the past 60 years to monitor and mitigate those effects, with an emphasis on downstream effects to fish populations. I briefly review methods that were used to predict effects, particularly on key fish species, and consider the role of adaptive management and its alternatives on resolving uncertainties about ecological effects of large hydroelectric projects.
Postoperative respiratory state assessment using the Integrated Pulmonary Index (IPI) and resultant nurse interventions in the post-anesthesia care unit: a randomized controlled trial
Authors: Broens Suzanne J. L. , Prins Susan A. , de Kleer Dorinne , Niesters Marieke , Dahan Albert , van Velzen Monique 
Published: July 2020

AbstractAlthough postoperative adverse respiratory events, defined by a decrease in respiratory rate (RR) and/or a drop in oxygen saturation (SpO2), occur frequently, many of such events are missed. The purpose of the current study was to assess whether continuous monitoring of the integrated pulmonary index (IPI), a composite index of SpO2, RR, end-tidal PCO2 and heart rate, alters our ability to identify and prevent adverse respiratory events in postoperative patients. Eighty postoperative patients were subjected to continuous respiratory monitoring during the first postoperative night using RR and pulse oximetry and the IPI monitor. Patients were randomized to receive intervention based on standard care (observational) or based on the IPI monitor (interventional). Nurses were asked to respond to adverse respiratory events with an intervention to improve the patient’s respiratory condition. There was no difference in the number of patients that experienced at least one adverse respiratory event: 21 and 16 in observational and interventional group, respectively (p = 0.218). Compared to the observational group, the use of the IPI monitor led to an increase in the number of interventions performed by nurses to improve the respiratory status of the patient (average 13 versus 39 interventions, p < 0.001). This difference was associated with a significant reduction of the median number of events per patient (2.5 versus 6, p < 0.05) and a shorter median duration of events (62 s versus 75 s, p < 0.001). The use of the IPI monitor in postoperative patients did not result in a reduction of the number of patients experiencing adverse respiratory events, compared to standard clinical care. However, it did lead to an increased number of nurse interventions and a decreased number and duration of respiratory events in patients that experienced postoperative adverse respiratory events.
Hayek on complexity, uncertainty and pandemic response
Authors: Pennington Mark 
Published: July 2020

AbstractThis paper draws on Hayek’s distinction between simple and complex phenomena to understand the nature of the challenge facing policymakers in responding to the new coronavirus pandemic. It shows that while government action is justifiable there may be few systemic mechanisms that enable policymakers to distinguish better from worse policy responses, or to make such distinctions in sufficient time. It then argues that this may be a more general characteristic of large-scale public policy making procedures and illustrates the importance of returning to a market-based political economy at the earliest convenience.
Fabrication and electrical characteristics of flash-sintered SiO2-doped ZnO-Bi2O3-MnO2 varistors
Authors: Peng Pai , Deng Yujun , Niu Jingpeng , Shi Liyi , Mei Yunzhu , Du Sanming , Liu Juan , Xu Dong 
Published: July 2020

AbstractThe dense ZnO-Bi2O3-MnO2-xSiO2 (ZBMS) varistors for x = 0, 1, 2, 3 wt% were fabricated by flash sintering method under the low temperature of 850 °C within 2 min. The sample temperature was estimated by a black body radiation model in the flash sintering process. The crystalline phase assemblage, density, microstructure, and electrical characteristics of the flash-sintered ZBMS varistors with different SiO2-doped content were investigated. According to the XRD analysis, many secondary phases were detected due to the SiO2 doping. Meanwhile, the average grain size decrease with increasing SiO2-doped content. The improved nonlinear characteristics were obtained in SiO2-doped samples, which can be attributed to the ion migration and oxygen absorption induced by the doped SiO2. The flash-sintered ZBMS varistor ceramics for x = 2 wt% exhibited excellent comprehensive electrical properties, with the nonlinear coefficient of 24.5, the threshold voltage and leakage current of 385 V·mm−1 and 11.8 µA, respectively.
MoS2 nanoparticles grown on carbon nanomaterials for lubricating oil additives
Authors: Gong Kuiliang , Lou Wenjing , Zhao Gaiqing , Wu Xinhu , Wang Xiaobo 
Published: July 2020

AbstractIn this study, the nanocomposites of MoS2 nanoparticles (NPs) grown on carbon nanotubes (MoS2@CNT), graphene (MoS2@Gr), and fullerene C60 (MoS2@C60) were synthesized, characterized, and evaluated for potential use as lubricant additives. By using the benefit of the synergistic effect between MoS2 and carbon nanomaterials (CNMs), these nanocomposites can be well dispersed in polyalkylene glycol (PAG) base oil and show superior stability compared with pure MoS2 NPs. Moreover, the dispersions of MoS2@CNT, MoS2@Gr, and MoS2@C60 added in PAG have noticeably improved friction reducing and antiwear (AW) behaviors at elevated temperature for comparison with that of PAG and PAG containing CNT, Gr, C60, and MoS2 NPs, respectively. The enhanced lubricating properties of these nanocomposites were also elucidated by exploring the tribofilm formed on the disc.
Fractionation of coal through organo-separative refining for enhancing its potential for the CO2-gasification
Authors: Dhawan Heena , Kumar Rohit , Upadhyayula Sreedevi , Pant K. K. , Sharma D. K. 
Published: July 2020

AbstractCoal gasification has already been extensively studied earlier under varying conditions of steam, CO2, O2, inert conditions. Belbaid coal and its e, N and NMP-DETA SCC products recovered through organo-refining under milder ambient pressure conditions were subjected to CO2-gasification in a fixed bed reactor under varying conditions. CO2 being an inert gas becomes the most challenging to be utilized during the gasification process. The SCCs showed better CO2-gasification reactivity than the raw Belbaid coal at 900 °C. The use of the catalyst K2CO3 tremendously increased the gasification reactivity for both raw coal and the SCCs. The use of sugarcane bagasse for CO2-gasification along with raw coal as well as with residual coal was also studied. Gasification under CO2 atmosphere conditions was used to structurally understand the coals as the coal structure gets loosened after extraction.
Adaptive Newton-Type Schemes Based on Projections
Authors: Amrein Mario , Hilber Norbert 
Published: July 2020

AbstractIn this work we present and discuss a possible globalization concept for Newton-type methods. We consider nonlinear problems $$f(x)=0$$

f
(
x
)
=
0

in $${\mathbb {R}}^{n}$$

R

n

using the concepts from ordinary differential equations as a basis for the proposed numerical solution procedure. Thus, the starting point of our approach is within the framework of solving ordinary differential equations numerically. Accordingly, we are able to reformulate general Newton-type iteration schemes using an adaptive step size control procedure. In doing so, we derive and discuss a discrete adaptive solution scheme, thereby trying to mimic the underlying continuous problem numerically without losing the famous quadratic convergence regime of the classical Newton method in a vicinity of a regular solution. The derivation of the proposed adaptive iteration scheme relies on a simple orthogonal projection argument taking into account that, sufficiently close to regular solutions, the vector field corresponding to the Newton scheme is approximately linear. We test and exemplify our adaptive root-finding scheme using a few low-dimensional examples. Based on the presented examples, we finally show some performance data.
Global Constitutionalism and Democracy: the Case of Colombia
Authors: Thornhill Chris , de Araújo Calabria Carina Rodrigues 
Published: July 2020

AbstractFocusing on the case of Colombia, this article sets out a sociological examination of constitutions marked by strong, activist judiciaries, by entrenched systems of human rights protection, and by emphatic implementation of global human rights law. Contra standard critiques of this constitutional model, it argues that such constitutions need to be seen as creating a new pattern of democracy, which is often distinctively adapted to structures in societies in which the typical patterns of legitimation and subject formation required for democratic government were obstructed. In polities with such constitutions, legal institutions and norm setters have at times assumed the status offunctional equivalentsfor more typical democratically mandated actors and institutions. In such polities, further, global law assumes essential importance as it creates new sources of normative authorization for legislation and stimulates new lines of articulation between government and society. The article concludes that analysis of such polities, exemplified by Colombia, shows that the common categories of democratic-constitutional analysis are no longer always adequate for understanding current tendencies in democratic formation, and they can easily undermine democracy itself.
4324 Phase 1 Sterile Product Formulation and Manufacturing at Academic Medical Centers: An Introduction for Translational Researchers
Authors: MacArthur Robert Bruce , Rockwell Kenneth , Johnson Amber , Vaughan Roger , Coller Barry S. 
Published: July 2020

OBJECTIVES/GOALS: To facilitate the development of innovative injection products by providing translational researchers with a regulatory and manufacturing road map for producing small batch sterile products for Phase 1 research use. To leverage recent AMC investments in facility improvements and pharmacy training in the areas of sterile product production, testing, and environmental controls, that can be used to support production of phase 1 clinical trial supplies METHODS/STUDY POPULATION: Searching and organizing relevant data and information from web portals and databases in the following: areas: FDA, EMA, USP regulations, regulatory science, pharmaceutical formulation and analytics, supply vendors, analytical testing laboratories, and product testing laboratories. Present the information using a user friendly format including flow charts and development timelines, taking the perspective of the translational investigator. RESULTS/ANTICIPATED RESULTS:
Choosing AMC resources vs outside consultants and vendors, leveraging local resources where possibleQualifying and monitoring suppliers, testing laboratories, in-house departments, and Contract Drug Manufacturing Organizations (CDMO)Bringing together the deliverables for the IND CMC sectionWhere and how to leverage available products and science to simplify safe and reliable productionDISCUSSION/SIGNIFICANCE OF IMPACT: Use and utility of injectable drug products, both small molecule and biologics, is growing rapidly, and is projected to continue to escalate well into the next decade. This is due not only to advances in medicine, but also to improvements in AMC-based sterile product production, and a better understanding of small batch manufacturing methods. All three trends align in academic medical centers (AMC) and can be utilized by translational researchers, if they can understand the potential and regulatory requirements.
4127 Achieving health equity in translational research: Applying critical race theory in workforce curricula to address disparity
Authors: Johnson Kristina Gern , Johnston Karen C. , Phillips Jennifer , Gusic Maryellen 
Published: July 2020

OBJECTIVES/GOALS: Learners will:
Identify social structures that serve as root causes of health disparitiesCritically evaluate the ways in which racism, culture, and power perpetuate disparityUse critical reflection to shape their research and advocate for institutional changeMETHODS/STUDY POPULATION: The Integrated Translational Health Research Institute of Virginia (iTHRIV) Health Equity curriculum provides a lens for participants to view health disparities, social structures that create and perpetuate disparities, and the path to a more equitable future. This longitudinal workforce curriculum incorporates the principles of critical race theory (CRT), including: race as a social construct, structural determinism, intersectionality, and the social construction of knowledge. Learners gain practical experience through facilitated group discussions and critical reflection of their own work including research question design, recruitment, dissemination, and enhancing the faculty pipeline. RESULTS/ANTICIPATED RESULTS: To measure the impact of the curriculum, we will evaluate learners’ participation in mentoring activities for persons from underrepresented backgrounds; participation in local and national diversity and inclusion efforts; engagement in community-based research; ability to account for implicit bias and power imbalances in their research design, including in recruitment and retention; and share research findings with community members and research participants. Evaluation strategies will include quantitative and qualitative methodologies. DISCUSSION/SIGNIFICANCE OF IMPACT: There is growing recognition of the impact of racism on the development and perpetuation of health disparities. Public health critical race praxis (an adaptation of CRT) is emerging as a theoretical framework to empower researchers to challenge the status quo in order to achieve health equity.