bluuebunny/crossref_metadata_2025_split huggingface dataset:
How peoples’ ratings of dental implant treatment change over time?
Authors: Machuca Carolina , Vettore Mario V. , Robinson Peter G. 
Published: January 2020

Abstract
Objectives
Dental implant treatment (DIT) improves peoples’ oral health-related quality of life (OHQoL). Assessment of longitudinal changes in OHRQoL may be undermined by response shift (RS). RS is the process by which quality of life changes, independent of health status as a result recalibration, reprioritization or reconceptualization. Thus, this study aimed to describe RS in the OHRQoL and perceived oral health of individuals receiving DIT and to compare the then-test, a self-anchored scale and the classification and regression trees (CRT) approaches for assessing RS.

Methods
OHRQoL was assessed in 100 patients receiving DIT using the OHIP-Edent (n = 100) and a self-anchored scale (n = 45) before placement of the final restoration and 3 to 6 months after treatment was completed. The OHIP-Edent was also used as a retrospective assessment at follow-up. CRT examined changes in the OHIP-Edent total score as a dependent variable with global changes in oral health and each OHIP-Edent subscale score as independent variables.

Results
OHRQoL and perceived oral health improved after treatment. The OHIP-Edent score decreased from 36.4 at baseline to 12.7 after treatment. On average, participants recalibrated their internal standard downwards (− 4.0 OHIP-Edent points). CRT detected downwards recalibration in 5% of participants and upwards in 15%. Reprioritization was observed in the social disability and psychological discomfort aspects of OHRQoL.

Conclusions
RS affects longitudinal assessments of OHRQoL in DIT, reducing the apparent magnitude of change. The then-test and CRT are valid and complementary methods to assess RS.
On the Maximization of the Science Output of Space Missions
Authors: Wu Ji , Giménez Alvaro 
Published: January 2020

AbstractManaging science-driven projects involve important differences with respect to other types of space missions. The main one is the character of science, exploring the unknown, that establishes how the final output is evaluated and thus the tools used to maximize it. For space missions supporting market-driven applications, the assessment of performance is clearly defined by the quality of the service provided and its added value. For space science missions, success is evaluated in terms of the advance of scientific knowledge, based on new discoveries and the tests of the laws of nature. The output can be facilitated but not fully predicted. Thus, performance has to consider initial science goals and the engineering requirements to achieve them but also, and most important, the preservation and maximization of the potential for unknown discoveries. The key indicator of the success of a space science mission is the quality and quantity of achieved scientific breakthroughs and discoveries. To optimize them, we need to consider the full mission lifecycle, from the mission definition through the development and its operations. In this paper, we discuss some management considerations to ensure and maximize the science output of a space mission over its whole lifecycle, from planning to operations. Specific elements are proposed to evaluate the results.
Shear deformability characteristics of a rapid-cure woven prepreg fabric
Authors: Khan M. A. , Pasco C. , Reynolds N. , Kendall K. 
Published: January 2020

AbstractFormability of a continuous fiber-reinforced material is known to be influenced by its intraply shear behavior. This study investigates a 2 × 2 twill weave carbon fabric and the corresponding vinyl-based thermoset prepreg developed for press-cured structural parts. Intraply shear tests of bias-extension and picture-frame were conducted for a range of industrial-relevant processing conditions of temperature and shear rate. The dry fabric was characterized similar to the prepreg to isolate the influence of semi-cured resin on the woven prepreg fabric formability in shear. The shear deformation behavior of the prepreg, usually dependent on the fabric architecture, is found to be controlled by the state of the resin. The results clearly show the significance of the choice of process parameters on the prepreg shear behavior. It is demonstrated that preheating the prepreg to temperatures considerably lower than required to initiate cure can make the shear formability of the woven prepreg equivalent to the constituent (dry) reinforcement fabric. The actual shear angle measurement during the bias-extension tests demonstrates the level of inter-tow slippage for the prepreg fabric at relatively elevated temperatures. The comparison of normalized shear data from the two test methods helps to determine the improved procedure for prepreg fabric testing.
Family, Firms, and Fertility: A Study of Social Interaction Effects
Authors: Buyukkececi Zafer , Leopold Thomas , van Gaalen Ruben , Engelhardt Henriette 
Published: January 2020

Abstract
Research has indicated that fertility spreads through social networks and attributed this phenomenon to social interaction effects. It remains unclear, however, whether the findings of previous studies reflect the direct influence of network partners or contextual and selection factors, such as shared environment and common background characteristics. The present study uses instrumental variables to improve the identification of social interaction effects on fertility. Using data from the System of social statistical data sets (SSD) of Statistics Netherlands, we identify two networks—the network of colleagues at the workplace and the network of siblings in the family—to examine the influence of network partners on individual fertility decisions. Discrete-time event-history models with random effects provide evidence for social interaction effects, showing that colleagues’ and siblings’ fertility have direct consequences for an individual’s fertility. Moreover, colleague effects are concentrated in female-female interactions, and women are more strongly influenced by their siblings, regardless of siblings’ gender. These results are the first to demonstrate spillover effects across network boundaries, suggesting that fertility effects accumulate through social ties not only within but also across different domains of interaction.
Prognostic significance of large diameter proximal aortic neck in	endovascular aneurysm repair
Authors: Antoniou George A. , Alfahad Aws , Antoniou Stavros A. , Badri Hassan 
Published: January 2020

Summary. Background: Adverse morphological features of the proximal aortic neck have been identified as culprits for late failure after endovascular aneurysm repair (EVAR). Our objective was to investigate the prognostic role of wide proximal aortic neck in EVAR. Methods: We conducted a review of the literature in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to identify studies comparing outcomes of EVAR in patients with large versus small proximal aortic neck. A meta-analysis of time-to-event data was performed with the inverse-variance method and the results were reported as summary hazard ratio (HR) and 95 % CI. We applied random-effects models of meta-analysis. Results: We identified 9 observational studies reporting on a total of 7,682 patients (1,961 with large diameter and 5,721 with small diameter neck). The hazard of death (HR 1.57, 95 % CI 1.23–2.01; P = 0.0003), aneurysm-related reintervention (HR 2.06, 95 % CI 1.23–3.45; P = 0.006), type Ia endoleak (HR 6.69, 95 % CI 4.39–10.20; P < 0.001), sac expansion (HR 10.07, 95 % CI 1.80–56.53; P = 0.009), aneurysm rupture (HR 2.96, 95 % CI 2.00–4.38; P < 0.0001), and neck-related adverse events (HR 10.33, 95 % CI 4.95–21.56; P < 0.0001) was higher in patients with large diameter proximal aortic neck than in those with small neck. Conclusions: Patients with a large proximal aortic neck were found to have poorer outcomes than those with small neck. This finding has implications in decision making when selecting methods for aneurysm treatment and in EVAR surveillance for aneurysm-related complications in this cohort of patients.
Why We Can No Longer Ignore Consecutive Disasters
Authors: de Ruiter Marleen C. , Couasnon Anaïs , van den Homberg Marc J. C. , Daniell James E. , Gill Joel C. , Ward Philip J. 
Published: January 2020

AbstractIn recent decades, a striking number of countries have suffered from consecutive disasters: events whose impacts overlap both spatially and temporally, while recovery is still under way. The risk of consecutive disasters will increase due to growing exposure, the interconnectedness of human society, and the increased frequency and intensity of nontectonic hazard. This paper provides an overview of the different types of consecutive disasters, their causes, and impacts. The impacts can be distinctly different from disasters occurring in isolation (both spatially and temporally) from other disasters, noting that full isolation never occurs. We use existing empirical disaster databases to show the global probabilistic occurrence for selected hazard types. Current state‐of‐the art risk assessment models and their outputs do not allow for a thorough representation and analysis of consecutive disasters. This is mainly due to the many challenges that are introduced by addressing and combining hazards of different nature, and accounting for their interactions and dynamics. Disaster risk management needs to be more holistic and codesigned between researchers, policy makers, first responders, and companies.
A Synthesis of Blue Carbon Stocks, Sources, and Accumulation Rates in Eelgrass (Zostera marina) Meadows in the Northeast Pacific
Authors: Prentice C. , Poppe K. L. , Lutz M. , Murray E. , Stephens T. A. , Spooner A. , Hessing‐Lewis M. , Sanders‐Smith R. , Rybczyk J. M. , Apple J. , Short F. T. , Gaeckle J. , Helms A. , Mattson C. , Raymond W. W. , Klinger T. 
Published: January 2020

AbstractThere is increasing urgency to implement climate change mitigation strategies that enhance greenhouse gas removal from the atmosphere and reduce carbon dioxide (CO2) emissions. Recently, coastal “blue carbon” habitats⁠—mangroves, salt marshes, and seagrass meadows—have received attention for their ability to capture CO2 and store organic carbon (OC), primarily in their sediments. Across habitat types and regions, however, information about the sequestration rates and sources of carbon to local sediments remains sparse. Here we compiled recently obtained estimates of sediment OC stocks and sequestration rates from 139 cores collected from temperate seagrass (Zostera marina) meadows in Alaska, British Columbia, Washington, and Oregon. Across all cores sediment OC content averaged 0.75%. Organic carbon stocks in the top 25 cm and 1 m of the sediment averaged 1,846 and 7,168 g OC m−2, respectively. Carbon sequestration rates ranged from 4.6 to 93.0 g OC m−2 yr−1 and averaged 24.8 g OC m−2 yr−1. Isotopic data from this region suggest that OC in the sediments is largely from noneelgrass sources. In general, these values are comparable to those from other temperate Z. marina meadows, but significantly lower than previously reported values for seagrasses globally. These results further highlight the need for local and species‐level quantification of blue carbon parameters. While temperate eelgrass meadows may not sequester and store as much carbon as seagrass meadows elsewhere, climate policy incentives should still be implemented to protect existing sediment carbon stocks and the other critical ecosystem services associated with eelgrass habitats.
LINC00665 promotes breast cancer progression through regulation of the miR-379-5p/LIN28B axis
Authors: Ji Wei , Diao Yu-Ling , Qiu Yi-Ran , Ge Jie , Cao Xu-Chen , Yu Yue 
Published: January 2020

AbstractBreast cancer is the most common malignant tumor among women worldwide. Although increasing evidence indicates that long noncoding RNAs (lncRNAs) play critical roles during breast tumorigenesis and progression, the involvement of most lncRNAs in breast cancer remains largely unknown. In the current study, we demonstrated that LINC00665 promotes breast cancer cell proliferation, migration, and invasion. Accumulating evidence indicates that many lncRNAs can function as endogenous miRNA sponges by competitively binding common miRNAs. In this study, we demonstrated that LINC00665 functions as a sponge for miR-379-5p, reducing the ability of miR-379-5p to repress LIN28B. LINC00665 promoted breast cancer progression and induced an epithelial–mesenchymal transition-like phenotype via the upregulation of LIN28B expression. Clinically, LINC00665 expression was increased but miR-379-5p expression was decreased in breast cancer tissues compared with that in normal breast tissues in the TCGA database. Furthermore, the expression of LINC00665 was negatively related with miR-379-5p expression. Collectively, our results reveal the LINC00665–miR-379-5p–LIN28B axis and shed light on breast cancer therapy.
The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxins
Authors: Suryamohan Kushal , Krishnankutty Sajesh P. , Guillory Joseph , Jevit Matthew , Schröder Markus S. , Wu Meng , Kuriakose Boney , Mathew Oommen K. , Perumal Rajadurai C. , Koludarov Ivan , Goldstein Leonard D. , Senger Kate , Dixon Mandumpala Davis , Velayutham Dinesh , Vargas Derek , Chaudhuri Subhra , Muraleedharan Megha , Goel Ridhi , Chen Ying-Jiun J. , Ratan Aakrosh , Liu Peter , Faherty Brendan , de la Rosa Guillermo , Shibata Hiroki , Baca Miriam , Sagolla Meredith , Ziai James , Wright Gus A. , Vucic Domagoj , Mohan Sangeetha , Antony Aju , Stinson Jeremy , Kirkpatrick Donald S. , Hannoush Rami N. , Durinck Steffen , Modrusan Zora , Stawiski Eric W. , Wiley Kristen , Raudsepp Terje , Kini R. Manjunatha , Zachariah Arun , Seshagiri Somasekar 
Published: January 2020

AbstractSnakebite envenoming is a serious and neglected tropical disease that kills ~100,000 people annually. High-quality, genome-enabled comprehensive characterization of toxin genes will facilitate development of effective humanized recombinant antivenom. We report a de novo near-chromosomal genome assembly of Naja naja, the Indian cobra, a highly venomous, medically important snake. Our assembly has a scaffold N50 of 223.35 Mb, with 19 scaffolds containing 95% of the genome. Of the 23,248 predicted protein-coding genes, 12,346 venom-gland-expressed genes constitute the ‘venom-ome’ and this included 139 genes from 33 toxin families. Among the 139 toxin genes were 19 ‘venom-ome-specific toxins’ (VSTs) that showed venom-gland-specific expression, and these probably encode the minimal core venom effector proteins. Synthetic venom reconstituted through recombinant VST expression will aid in the rapid development of safe and effective synthetic antivenom. Additionally, our genome could serve as a reference for snake genomes, support evolutionary studies and enable venom-driven drug discovery.
La région charnière des anticorps thérapeutiques
Authors: Deveuve Quentin , Gouilleux-Gruart Valérie , Thibault Gilles , Lajoie Laurie 
Published: January 2020

La région charnière est une courte séquence des chaînes lourdes (H) d’anticorps liant le Fab (fragment antigen binding) au Fc (fragment crystallisable). Les propriétés fonctionnelles des quatre sous-classes d’immunoglobulines d’isotype G (IgG) résultent en partie des différences de séquence de leurs régions charnières. En effet, certains acides aminés de la partie C-terminale de ces régions charnières (« partie basse ») sont situés au sein ou à proximité des sites de liaison de la molécule C1q de la voie classique du complément et des récepteurs pour la région Fc des IgG (RFcγ) sur les chaînes H d’IgG. Les régions charnières sont également sensibles au clivage protéolytique par de nombreuses protéases du microenvironnement tumoral et/ou inflammatoire pouvant altérer les réponses fonctionnelles. Le format optimal de la charnière reste donc un défi majeur pour le développement de nouveaux anticorps thérapeutiques.
Complications following Suture Button Use for Femoral Graft Fixation in Arthroscopic Anterior Cruciate Ligament Reconstruction: A Systematic Review
Authors: Yassa R. , Adam J. R. , Charalambous C. P. 
Published: January 2020

AbstractUnderstanding any potential complications that may occur in relation to the use of a suture button for femoral graft fixation in arthroscopic anterior cruciate ligament reconstruction can help raise awareness among surgeons and improve safety when using such implants. This is a systematic review of suture button related complications. A literature search was conducted using the PubMed, Embase, and CINAHL (Cumulative Index to Nursing and Allied Health Literature) databases from their year of inception until January 3, 2019. We included studies reporting on suture button related complications in their outcomes of femoral graft suture button fixation in anterior cruciate ligament reconstruction. Our search identified 479 articles, of which 19 met our inclusion criteria. Suture button misplacement (initial or subsequent migration) was the most commonly reported complication. Although, in most cases, button misplacement is minimal and does not adversely affect clinical outcomes, in some cases it may lead to graft failure or local soft tissue irritation and require further surgery. Intraoperative screening or arthroscopic evaluation of the deployed suture button may reduce this complication.
DeepKinZero: zero-shot learning for predicting kinase–phosphosite associations involving understudied kinases
Authors: Deznabi Iman , Arabaci Busra , Koyutürk Mehmet , Tastan Oznur 
Published: January 2020

Abstract

Motivation
Protein phosphorylation is a key regulator of protein function in signal transduction pathways. Kinases are the enzymes that catalyze the phosphorylation of other proteins in a target-specific manner. The dysregulation of phosphorylation is associated with many diseases including cancer. Although the advances in phosphoproteomics enable the identification of phosphosites at the proteome level, most of the phosphoproteome is still in the dark: more than 95% of the reported human phosphosites have no known kinases. Determining which kinase is responsible for phosphorylating a site remains an experimental challenge. Existing computational methods require several examples of known targets of a kinase to make accurate kinase-specific predictions, yet for a large body of kinases, only a few or no target sites are reported.

Results
We present DeepKinZero, the first zero-shot learning approach to predict the kinase acting on a phosphosite for kinases with no known phosphosite information. DeepKinZero transfers knowledge from kinases with many known target phosphosites to those kinases with no known sites through a zero-shot learning model. The kinase-specific positional amino acid preferences are learned using a bidirectional recurrent neural network. We show that DeepKinZero achieves significant improvement in accuracy for kinases with no known phosphosites in comparison to the baseline model and other methods available. By expanding our knowledge on understudied kinases, DeepKinZero can help to chart the phosphoproteome atlas.

Availability and implementation
The source codes are available at https://github.com/Tastanlab/DeepKinZero.

Supplementary information
Supplementary data are available at Bioinformatics online.
US Hegemony and the Trans-Pacific Partnership: Consensus, Crisis, and Common Sense
Authors: Biegon Rubrick 
Published: January 2020

Abstract
This article provides a critical analysis of the agency of the United States in the Trans-Pacific Partnership (TPP). Building on neo-Gramscian theory, it contextualises the US decision to withdraw from the TPP as an expression of hegemonic crisis. Through an examination of the strategic and geoeconomic logics and objectives of the trade agreement in US foreign economic policy, it maintains that the TPP was intended primarily to expand the structural and consensual power of the United States in the international political economy. Partly an attempt to kick-start a stalled neoliberal agenda, the TPP was also an effort to respond to China’s growing influence in trade governance. The article argues that, despite the revival of the TPP in the form of the Comprehensive and Progressive Agreement for Trans-Pacific Partnership, the inability of elite networks in the United States to implement the original accord is illustrative of a crisis of hegemony driven largely by the collapse of the ‘common sense’ in favour of economic globalisation.
Artificial intelligence in the legal sector: pressures and challenges of transformation
Authors: Brooks Chay , Gherhes Cristian , Vorley Tim 
Published: January 2020

AbstractRecent technological developments in automation and artificial intelligence (AI) promise to disrupt the very foundations of how legal work is practised and delivered. Yet how they challenge current business models, where they encounter resistance and how the benefits of AI can be realised remain unexplored. Drawing on interviews with professionals in the UK legal services sector, the article highlights how technological and market pressures combine to challenge the business models of legal services firms. However, the findings reveal important cultural and structural challenges that hamper transformation. The article extends the debate on technological disruption in legal services through a focus on business model innovation as a tool that can support firms in the sector to reimagine legal services provision.
Capitate Glandular Trichomes Fail to Provide Significant Resistance to Banded Sunflower Moth (Lepidoptera: Tortricidae)
Authors: Prasifka Jarrad R , Hulke Brent S 
Published: January 2020

Abstract
Extracts from capitate glandular trichomes (CGT) of wild and cultivated sunflowers, Helianthus spp., have repellent or toxic effects on sunflower specialists and generalist herbivores less closely associated with sunflower. Though CGT have been primarily examined for their potential to provide partial resistance to the sunflower moth, Homoeosoma electellum Hulst (Lepidoptera: Pyralidae), a floret- and seed-feeding pest, the banded sunflower moth (Cochylis hospes Walsingham [Lepidoptera: Tortricidae]) is a similar species more common in the primary sunflower-producing states of North Dakota and South Dakota. Replicated field trials using partially inbred lines with low or high CGT densities were used to evaluate possible reductions to seed damage by C. hospes larvae in 2016–2017. Results failed to support the idea that CGT are a useful defense against larvae of C. hospes; the putative plant defense of high trichome density corresponded to slightly more, rather than less, insect damage. A test of a secondary explanation, that strength of sunflower hulls could help determine patterns of seed damage among tested lines, produced similarly negative results. Though timing of bloom differed between groups of most- and least-damaged lines, prior research and pheromone-trapping data suggest differences in plant maturity also cannot adequately explain the observed results. While the specific mechanisms remain unclear, significant differences in susceptibility to C. hospes exist for cultivated sunflower and limit losses from this primary insect pest.