bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of the implementation of best practice guidelines on nurse’s evidence‐based practice and on nurses' work environment: Research protocol
Authors: Esteban‐Sepúlveda Silvia , Sesé‐Abad Albert , Lacueva‐Pérez Laia , Domingo‐Pozo Manuela , Alonso‐Fernandez Sergio , Aquilue‐Ballarin Marta , Barcelo‐Martinez Ana Isabel , Cristobal‐Dominguez Estíbaliz , Bujalance‐Hoyos Jesús , Dossantos‐Sanchez Consuelo , Pascual‐Pascual Manuel Angel , Garcia‐Arteaga Elisabeth , Galisteo‐Gimenez Maria , Mas‐Dalmau Gemma , Heredia‐Reina Maria Pilar , Roca‐Marti Silvia , Riart María Perez , Albornos‐Muñoz Laura , Gonzalez‐Maria Esther , Fernández‐Domínguez Juan Carlos 
Published: October 2020

AbstractAimTo determine the impact of the Best Practice Spotlight Organization® initiative on nurses’ perception of their work environment and their attitudes to evidence‐based practice.DesignQuasi‐experimental, multicentre study. The intervention is the participation in Best Prectice Spotilight Organizations to implement Best Practice Guidelines.MethodsThe study will include seven centres in the interventional group and 10 in the non‐equivalent control group, all of them belonging to the Spanish national health system. The Practice Environment Scale of the Nursing Work Index, and the Health Sciences Evidence‐Based Practice Questionnaire will be administered to a sample of 1,572 nurses at the beginning of the programme and at 1 year. This 3‐year study started in April 2018 and will continue until December 2021. Statistical analyses will be carried out using the SPSS 25.0. This project was approved by the Drug Research Ethics Committee of the Parc de Salut Mar and registered in Clinical Trials.DiscussionThe study findings will show the current state of nurses’ perception of their work environment and attitudes to evidence‐based practice, and possible changes in these parameters due to the programme.ImpactThe findings could provide a strong argument for health policymakers to scale up the Best Practice Spotlight Organization® initiative in the Spanish national health system.
Implantation of leadless pacemakers via inferior vena cava filters is feasible and safe: Insights from a multicenter experience
Authors: Houmsse Mahmoud , Karki Roshan , Gabriels James , Reinig Michael , Patel Dilesh , Hussain Sarah K. , Gandhi Gaurang D. , Lloyd Michael S. , Makary Mina S. , Okabe Toshimasa , Tamirisa Kamala , Joza Jacqueline , Patel Apoor , Afzal Muhammad R. , Epstein Laurence M. , Cha Yong‐Mei 
Published: October 2020

AbstractBackgroundThe leadless Micra transcatheter‐pacing system (Micra‐TPS) is implanted via a femoral approach using a 27‐French introducer sheath. The Micra Transcutaneous Pacing Study excluded patients with inferior vena cava (IVC) filters.ObjectiveTo examine the feasibility and safety of Micra‐TPS implantation through an IVC filter.MethodsThis multicenter retrospective study included patients with an IVC filter who underwent a Micra‐TPS implantation. Data for clinical and IVC filter characteristics, preprocedure imaging, and procedural interventions were collected. The primary outcome was a successful leadless pacemaker (LP) implantation via a femoral approach in the presence of an IVC filter. Periprocedural and delayed clinical complications were also evaluated.ResultsOf the 1528 Micra‐TPS implants attempted, 23 patients (1.5%) had IVC filters. The majority (69.6%) of IVC filters were permanent. Six (26.1%) patients underwent preprocedural imaging to assess for filter patency. One patient's filter was retrieved before LP implantation. The primary outcome was achieved in 21 of 22 patients (95.5%) with an existing IVC filter. An occluded IVC precluded LP implantation in one patient. Difficulty advancing the stiff guidewire or the 27‐Fr sheath was encountered in five patients. These cases required repositioning of the wire (n = 2), gradual sheath upsizing (n = 2), or balloon dilation of the filter (n = 1). Postprocedure fluoroscopy revealed intact filters in all cases. During a median 6‐month follow‐up, there were no clinical complications related to the filter or the Micra‐TPS.ConclusionThis multicenter experience demonstrates the feasibility and safety of Micra‐TPS implantation via an IVC filter without acute procedural or delayed clinical complications.
Vascular entrapment of a multipolar basket catheter (OrionTM) during catheter ablation
Authors: Ollitrault Pierre , Champ‐Rigot Laure , Ferchaud Virginie , Pellissier Arnaud , Coffin Olivier , Milliez Paul 
Published: October 2020

AbstractThe IntellaMap OrionTM (Boston Scientific) is a 64‐electrode basket catheter allowing for ultrahigh‐density mapping of complex cardiac arrhythmias. We report the case of a basket catheter vascular entrapment, requiring surgical removal.
Loss of TG‐Interacting Factor 1 decreases survival in mouse models of myeloid leukaemia
Authors: Yan Ling , Davé Utpal P. , Engel Michael , Brandt Stephen J. , Hamid Rizwan 
Published: October 2020

AbstractTG‐Interacting Factor 1 (Tgif1) affects proliferation and differentiation of myeloid cells and regulates self‐renewal of haematopoietic stem cells (HSCs). To determine its impact on leukaemic haematopoiesis, we induced acute or chronic myeloid leukaemias (AML or CML) in mice by enforced expression of MLL‐AF9 or BCR‐ABL, respectively, in Tgif1+/+ or Tgif1−/− haematopoietic stem and progenitor cells (HSPCs) and transplanted them into syngeneic recipients. We find that loss of Tgif1 accelerates leukaemic progression and shortens survival in mice with either AML or CML. Leukaemia‐initiating cells (LICs) occur with higher frequency in AML among mice transplanted with MLL‐AF9‐transduced Tgif1−/− HSPCs than with Tgif1+/+ BMCs. Moreover, AML in mice generated with Tgif1−/− HSPCs are chemotherapy resistant and relapse more rapidly than those whose AML arose in Tgif1+/+ HSPCs. Whole transcriptome analysis shows significant alterations in gene expression profiles associated with transforming growth factor‐beta (TGF‐beta) and retinoic acid (RA) signalling pathways because of Tgif1 loss. These findings indicate that Tgif1 has a protective role in myeloid leukaemia initiation and progression, and its anti‐leukaemic contributions are connected to TGF‐beta‐ and RA‐driven functions.
Distinct performance profiles on the Brixton test in frontotemporal dementia
Authors: Rao Sulakshana P. , Nandi Ranita , Dutt Aparna , Kapur Narinder , Harris Jennifer M. , Thompson Jennifer C. , Snowden Julie S. 
Published: October 2020

The Brixton Spatial Anticipation Test is a well‐established test of executive function that evaluates the capacity to abstract, follow, and switch rules. There has been remarkably little systematic analysis of Brixton test performance in the prototypical neurodegenerative disorder of the frontal lobes: behavioural variant frontotemporal dementia (bvFTD) or evaluation of the test’s ability to distinguish frontal from temporal lobe degenerative disease. We carried out a quantitative and qualitative analysis of Brixton performance in 76 patients with bvFTD and 34 with semantic dementia (SD) associated with temporal lobe degeneration. The groups were matched for demographic variables and illness duration. The bvFTD group performed significantly more poorly (U = 348, p < .0001, r = .58), 53% of patients scoring in the poor–impaired range compared with 6% of SD patients. Whereas bvFTD patients showed problems in rule acquisition and switching, SD patients did not, despite their impaired conceptual knowledge. Error analysis revealed more frequent perseverative errors in bvFTD, particularly responses unconnected to the stimulus, as well as random responses. Stimulus‐bound errors were rare. Within the bvFTD group, there was variation in performance profile, which could not be explained by demographic, neurological, or genetic factors. The findings demonstrate sensitivity and specificity of the Brixton test in identifying frontal lobe degenerative disease and highlight the clinical value of qualitative analysis of test performance. From a theoretical perspective, the findings provide evidence that semantic knowledge and the capacity to acquire rules are dissociable. Moreover, they exemplify the separable functional contributions to executive performance.
Phenotypic features and fertility outcomes of women with polycystic ovary syndrome: The effect of quality of life
Authors: Zhang Duojia , Gao Jingshu , Qin Huichao , Chang Hui , Wu Xiaoke 
Published: October 2020

AbstractAimThis work sought to evaluate the correlation between the five domains of the Polycystic Ovary Syndrome Questionnaire (PCOSQ) and anxiety and depression scales and the clinical phenotype and fertility outcomes in infertile polycystic ovary syndrome (PCOS) patients and to determine the effect of quality of life (QOL) on the clinical, biochemical and fertility disorders in these patients.MethodsThe data in this study came from a large‐scale hospital‐based cohort survey of infertile PCOS patients across mainland China. A total of 1000 infertile PCOS subjects diagnosed according to the modified Rotterdam criteria ranging in age from 20 to 40 years in 21 sub‐centers (27 hospitals) were enrolled. Baseline anthropometric parameters, endocrine indexes, metabolic panel, QOL questionnaires and the fertility outcomes of ovulation, conception, pregnancy, pregnancy loss and live birth were collected.ResultsPCOSQ scores were significantly correlated with most of the baseline parameters. PCOSQ‐weight domain scores of National Institute of Health‐PCOS group were significantly lower compared with non‐National Institute of Health‐PCOS group. The five domains scores of PCOSQ were significantly negatively correlated with the body mass index levels of PCOS patients. The serum testosterone levels (total testosterone, free testosterone and free androgen index) were significantly negatively correlated to the scores for the weight, body hair, infertility and emotion domains of PCOSQ. Scores on the anxiety and depression scales were significantly and positively correlated with luteinizing hormone, luteinizing hormone/follicle‐stimulating hormone levels. In the low‐score group of infertility domain, the rates of conception, pregnancy and live birth decreased significantly.ConclusionsQOL appears to have an impact on the physical symptoms of PCOS, and the emotional stress of infertility affects fertility outcomes.
Oral health‐related quality of life in X‐linked hypophosphataemia and osteogenesis imperfecta
Authors: Gjørup Hans , Beck‐Nielsen Signe Sparre , Hald Jannie Dahl , Haubek Dorte 
Published: October 2020

AbstractX‐linked hypophosphataemia (XLH) and osteogenesis imperfecta (OI) are rare congenital disorders characterised by skeletal dysplasia. The two disorders may include dental anomalies potentially affecting individual well‐being. The aims of study were (a) to assess the oral health‐related quality of life (OHRQoL) in Danish adults with XLH or OI, and (b) to compare the results of the groups. A cross‐sectional study including 35 adults with XLH, 56 adults with OI type I and 17 adults with OI types III‐IV was conducted. The OHRQoL was assessed by the 49‐item version of the questionnaire Oral Health Impact Profile (OHIP). Summed domain scores (seven) were compared between XLH and OI groups. Prevalence of severe impact on OHRQoL (scores 3‐4) was compared between groups. The median scores in XLH group exceeded the medians in OI (P < .05) in the domains functional limitation (XLH:6.5; OI:4.0), pain (XLH:9.5; OI:5.0), psychological discomfort (XLH:5.5; OI:2.0), psychological disability (XLH:2.0; OI:0.0), handicap (XLH:2.0; OI:0.0) and total OHIP (XLH:35.0; OI:14.0). Differences in domains physical disability (XLH: 4.0; OI: 1.0) and social disability (XLH: 0.0; OI: 0.0) were not significant. Prevalence of severe impact on OHRQoL in the XLH group significantly exceeded the level in OI group in the domains functional limitation (XLH: 59%; OI: 35%), psychological discomfort (XLH: 38%; OI: 20%) and physical disability (XLH: 32%; OI: 13%). In conclusion, adults with XLH experience a higher negative impact on their OHRQoL than adults with OI. Only to a minor degree, individuals with OI types III‐IV experience a higher impact on OHRQoL than individuals with OI type I.
Polyclonal B‐cell lymphocytosis in English bulldogs
Authors: Rout Emily D. , Moore A Russell , Burnett Robert C. , Labadie Julia D. , Hughes Kelly L. , Navin Paul A. , Yoshimoto Janna A. , Avery Paul R. , Avery Anne C. 
Published: October 2020

AbstractBackgroundEnglish bulldogs disproportionally develop an expansion of small B‐cells, which has been interpreted as B‐cell chronic lymphocytic leukemia (BCLL). However, clonality testing in these cases has often not been supportive of neoplasia.HypothesisEnglish bulldogs have a syndrome of nonneoplastic B‐cell expansion.AnimalsEighty‐four English bulldogs with small‐sizedCD21+ B‐cell lymphocytosis in the blood as determined by flow cytometry.MethodsThis is a retrospective study. We characterized this syndrome by assessing B‐cell clonality, clinical presentation, flow cytometric features, and immunoglobulin gammopathy patterns. We identified 84 cases with CD21+ lymphocytosis among 195 English bulldogs with blood samples submitted to the Colorado State University‐Clinical Immunology laboratory for immunophenotyping between 2010 and 2019. Flow cytometry features were compared to normal B‐cells and BCLL cases. PCR for antigen receptor rearrangements (PARR) by multiple immunoglobulin primers was performed to assess B‐cell clonality. A subset of cases with gammopathy were examined by protein electrophoresis, immunofixation, and immunoglobulin subclass ELISA quantification.ResultsSeventy percent (58/83) of cases had polyclonal or restricted polyclonal immunoglobulin gene rearrangements, suggesting nonmalignant B‐cell expansion. The median age of all dogs in the study was 6.8 years and 74% were male. The median (range) lymphocyte count was 22 400/μL (2000‐384 400/μL) and B‐cells had low expression of class II MHC and CD25. Splenomegaly or splenic masses were detected in 57% (26/46) of cases and lymphadenopathy in 11% (7/61). Seventy‐one percent (52/73) of cases had hyperglobulinemia and 77% (23/30) with globulin characterization had IgA ± IgM polyclonal or restricted polyclonal gammopathy patterns.Conclusions and Clinical ImportancePolyclonal B‐cell lymphocytosis in English bulldogs is characterized by low B‐cell class II MHC and CD25 expression, splenomegaly and hyperglobulinemia consisting of increased IgA ± IgM. We hypothesize that this syndrome has a genetic basis.
Effects of salinity on growth characteristics and osmoregulation of juvenile cobia, Rachycentron canadum (Linnaeus 1766), reared in potassium‐amended inland saline groundwater
Authors: Antony Jose , Reddy Appidi Krishna , Sudhagar Arun , Vungurala Hari Krishna , Roy Luke A 
Published: October 2020

AbstractThe suitability of inland saline groundwater as a medium to culture juvenile cobia, Rachycentron canadum, was assessed. In the first experiment, juvenile cobia stocked in raw (unamended) saline groundwater at salinities of 5, 10, and 15 g/L exhibited complete mortality after 108, 176, and 195 hr, respectively. The second experiment evaluated the rearing of juvenile cobia (mean weight ~9.23 ± 0.12 g) in potassium (K+)‐amended saline groundwater (100% K+ fortified) and reconstituted seawater at salinities of 5, 10, and 15 g/L to assess growth and osmoregulation in distinct culture media. Following 60 days of culture, all fish survived the experimental period. Final mean bodyweight of cobia reared in K+‐amended saline groundwater (103.2–115.8 g) and seawater (111.2–113.8 g) of different salinities did not vary significantly (p > .05). No differences (p > .05) were observed in specific growth rate, weight gain (%), and feed conversion ratio between treatment groups. Serum osmolality increased with salinity and was significantly higher (p < .05) for fish in K+‐amended saline groundwater (353–361 mOsmol/Kg) than in reconstituted seawater (319–332 mOsmol/Kg), although differences were not observed between salinities by water type. Cobia stocked in saline groundwater of different salinities were osmoregulating normally, and the higher values observed may be because of variations in ionic composition and other interfering ions in saline groundwater. Trial results suggest that juvenile cobia can achieve optimal growth in K+‐amended saline groundwater of low and intermediate salinities.
Weak tradeoff between xylem hydraulic efficiency and safety: climatic seasonality matters
Authors: Liu Hui , Ye Qing , Gleason Sean M. , He Pengcheng , Yin Deyi 
Published: October 2020

Summary

A classic theory proposes that plant xylem cannot be both highly efficient in water transport and resistant to embolism, and therefore a hydraulic efficiency–safety trade‐off should exist. However, the trade‐off is weak, and many species exhibit both low efficiency and low safety, falling outside of the expected trade‐off space. It remains unclear under what climatic conditions these species could maintain competitive fitness.

We compiled hydraulic efficiency and safety traits for 682 observations of 499 woody species from 178 sites world‐wide and measured the position of each observation within the proposed trade‐off space.

For both angiosperms and gymnosperms, observations from sites with high climatic seasonality, especially precipitation seasonality, tended to have higher hydraulic safety and efficiency than observations from sites with low seasonality. Specifically, high vapour pressure deficit, high solar radiation, and low precipitation during the wet season were driving factors.

Strong climatic seasonality and drought in both dry and wet seasons appear to be ecological filters that select for species with co‐optimized safety and efficiency, whereas the opposite environmental conditions may allow the existence of plants with low efficiency and safety.
Trees as net sinks for methane (CH4) and nitrous oxide (N2O) in the lowland tropical rain forest on volcanic Réunion Island
Authors: Machacova Katerina , Borak Libor , Agyei Thomas , Schindler Thomas , Soosaar Kaido , Mander Ülo , Ah‐Peng Claudine 
Published: October 2020

Summary

Trees are known to emit methane (CH4) and nitrous oxide (N2O), with tropical wetland trees being considerable CH4 sources. Little is known about CH4 and especially N2O exchange of trees growing in tropical rain forests under nonflooded conditions.

We determined CH4 and N2O exchange of stems of six dominant tree species, cryptogamic stem covers, soils and volcanic surfaces at the start of the rainy season in a 400‐yr‐old tropical lowland rain forest situated on a basaltic lava flow (Réunion Island). We aimed to understand the unknown role in greenhouse gas fluxes of these atypical tropical rain forests on basaltic lava flows.

The stems studied were net sinks for atmospheric CH4 and N2O, as were cryptogams, which seemed to be co‐responsible for the stem uptake. In contrast with more commonly studied rain forests, the soil and previously unexplored volcanic surfaces consumed CH4. Their N2O fluxes were negligible.

Greenhouse gas uptake potential by trees and cryptogams constitutes a novel and unique finding, thus showing that plants can serve not only as emitters, but also as consumers of CH4 and N2O. The volcanic tropical lowland rain forest appears to be an important CH4 sink, as well as a possible N2O sink.
RNA polymerase II associated proteins regulate stomatal development through direct interaction with stomatal transcription factors in Arabidopsis thaliana
Authors: Chen Liang , Zhao Mingfeng , Wu Zhongliang , Chen Sicheng , Rojo Enrique , Luo Jiangwei , Li Ping , Zhao Lulu , Chen Yan , Deng Jianming , Cheng Bo , He Kai , Gou Xiaoping , Li Jia , Hou Suiwen 
Published: October 2020

Summary

RNA polymerase II (Pol II) associated proteins (RPAPs) have been ascribed diverse functions at the cellular level; however, their roles in developmental processes in yeasts, animals and plants are very poorly understood.

Through screening for interactors of NRPB3, which encodes the third largest subunit of Pol II, we identified RIMA, the orthologue of mammalian RPAP2. A combination of genetic and biochemical assays revealed the role of RIMA and other RPAPs in stomatal development in Arabidopsis thaliana.

We show that RIMA is involved in nuclear import of NRPB3 and other Pol II subunits, and is essential for restraining division and for establishing cell identity in the stomatal cell lineage. Moreover, plant RPAPs IYO/RPAP1 and QQT1/RPAP4, which interact with RIMA, are also crucial for stomatal development. Importantly, RIMA and QQT1 bind physically to stomatal transcription factors SPEECHLESS, MUTE, FAMA and SCREAMs.

The RIMA‐QQT1‐IYO complex could work together with key stomatal transcription factors and Pol II to drive cell fate transitions in the stomatal cell lineage. Direct interactions with stomatal transcription factors provide a novel mechanism by which RPAP proteins may control differentiation of cell types and tissues in eukaryotes.
Kasulis’ intimacy/integrity heuristic and epistemological pluralism in nursing
Authors: McCaffrey Graham 
Published: October 2020

AbstractEpistemological pluralism is a recognized feature of nursing knowledge, which embraces both objective, scientific knowledge and situated knowledge that include subjective experience, values and affect, and is encountered in relationship. While there is a lively literature about describing and validating the need for pluralism in nursing's knowledge base, there has been less discussion of how to work with and across different kinds of knowing that are used in practice. In this paper, I describe Kasulis’ heuristic framework for understanding more clearly what is entailed in different kinds of knowledge, and what some of their advantages and disadvantages might be. The framework was created by Thomas Kasulis, an American scholar of Japanese philosophy who identified broad orientations in Asian and Western philosophies that he characterized as ‘intimacy’ and ‘integrity’, respectively. Kasulis emphasized that his framework is a heuristic, a tool for making distinctions more clearly between different styles of thinking, that can manifest not only between cultural traditions from different parts of the world, but also between subcultures within one of the dominant orientations. He breaks his two orientations down by five distinguishing categories of objectivity, relating, affect, embodiment and transparency. In this paper, each category is described and discussed in relation to aspects of nursing knowledge. Looking at different epistemological viewpoints in this way helps to clarify their differences, and to explain the difficulty of reading across them, when they entail basic assumptions that are not commensurable with each other. Kasulis’ framework offers a new way of reading across viewpoints commonly seen in the epistemological pluralism of nursing. It is a tool that can sharpen critical discernment about what is at stake, what can be gained, and what might get missed while operating in either the intimacy or integrity orientation.