bluuebunny/crossref_metadata_2025_split huggingface dataset:
Openness and trust in data-intensive science: the case of biocuration
Authors: Gabrielsen Ane Møller 
Published: June 2020

AbstractData-intensive science comes with increased risks concerning quality and reliability of data, and while trust in science has traditionally been framed as a matter of scientists being expected to adhere to certain technical and moral norms for behaviour, emerging discourses of open science present openness and transparency as substitutes for established trust mechanisms. By ensuring access to all available information, quality becomes a matter of informed judgement by the users, and trust no longer seems necessary. This strategy does not, however, take into consideration the networks of professionals already enabling data-intensive science by providing high-quality data. In the life sciences, biological data- and knowledge bases managed by expert biocurators have become crucial for data-intensive research. In this paper, I will use the case of biocurators to argue that openness and transparency will not diminish the need for trust in data-intensive science. On the contrary, data-intensive science requires a reconfiguration of existing trust mechanisms in order to include those who take care of and manage scientific data after its production.
Validity and reliability of the Arabic version of the child perceptions questionnaire for 8–10-year-old children
Authors: Al-Blaihed Deem , El-Housseiny Azza A. , Farsi Nada J. , Farsi Najat M. 
Published: June 2020

Abstract
Purpose
To develop an Arabic version of the CPQ8–10 and test its validity and reliability for use among Arabic-speaking children.

Methods
The 25-item professionally translated questionnaire included two global rating questions across four domains, which was assessed through a pilot study on 20 participants who were not included in the main study. Children (n = 175) aged 8–10 years were consecutively recruited: group I (n = 120) included pediatric dental patients, group II (n = 25) included children with orofacial clefts, and group III (n = 30) included orthodontic patients. Construct (convergent and discriminant) validity, internal consistency, and test–retest reliability were assessed using Spearman’s rank correlation coefficients, Cronbach’s alpha coefficient, and intraclass correlation coefficient, respectively. All children were clinically examined; 66 children completed the questionnaire a second time. A cross-sectional study design was employed.

Results
CPQ8–10 scores and global ratings were positively correlated. CPQ8–10 scores were highest in group II, followed by groups I and III, respectively. CPQ8–10 scores were significantly higher in children affected with caries or malocclusion compared to unaffected children. Cronbach’s alpha was 0.95 and the intraclass correlation coefficient was 0.97.

Conclusions
The Arabic CPQ8–10 was valid and reliable; therefore, it can be utilized with Arabic-speaking children in this age group.
Social media marketing strategy: definition, conceptualization, taxonomy, validation, and future agenda
Authors: Li Fangfang , Larimo Jorma , Leonidou Leonidas C. 
Published: June 2020

AbstractAlthough social media use is gaining increasing importance as a component of firms’ portfolio of strategies, scant research has systematically consolidated and extended knowledge on social media marketing strategies (SMMSs). To fill this research gap, we first define SMMS, using social media and marketing strategy dimensions. This is followed by a conceptualization of the developmental process of SMMSs, which comprises four major components, namely drivers, inputs, throughputs, and outputs. Next, we propose a taxonomy that classifies SMMSs into four types according to their strategic maturity level: social commerce strategy, social content strategy, social monitoring strategy, and social CRM strategy. We subsequently validate this taxonomy of SMMSs using information derived from prior empirical studies, as well with data collected from in-depth interviews and a quantitive survey among social media marketing managers. Finally, we suggest fruitful directions for future research based on input received from scholars specializing in the field.
Effects of Load Reductions on Phosphorus Concentrations in a Baltic Estuary—Long-Term Changes, Seasonal Variation, and Management Implications
Authors: Walve Jakob , Sandberg Maria , Elmgren Ragnar , Lännergren Christer , Larsson Ulf 
Published: June 2020

AbstractNutrient concentrations in coastal waters are influenced not only by land runoff, point sources, and water exchange with the sea but are also modified by settlement to and release from sediments. This complicates evaluation of measures to reduce nutrient loads. We used a mass-balance box model to calculate long-term (1968–2015) and seasonal source contributions to phosphorus (P) concentrations and cycling in the stratified Stockholm inner archipelago (IA), Baltic Sea. A drastic reduction of sewage P loads in the early 1970s reduced sewage from the major to a minor P source. Further P load reductions in the 1990s cut the direct contribution from the sewage point sources to the annual mean surface water P concentration from 10 μg l−1(25%) to < 4 μg l−1(12%). The largest contributions to the surface water P concentration are now (from 1996) inflowing seawater (37%), freshwater (25%), and P recycling from sediments below 20 m depth (26%). Variations in freshwater flushing give higher P concentrations in dry years, when dilution of P inputs from sediments and sewage is small, while in wet years, these inputs are greatly diluted. Source-partitioned phosphate uptake shows that the spring bloom is fueled mainly by P of seawater and freshwater origin, while the contribution from sewage point sources is minor. Since sediment P release is mostly recycled P from the settled spring bloom, the P inputs from seawater and freshwater are now the major drivers of the IA P cycle. Recycling of P from sediments boosts surface water P concentrations in autumn and winter, affecting management target concentrations.
Treatment of Primary Autoimmune Cerebellar Ataxia with Mycophenolate
Authors: Hadjivassiliou M. , Grunewald R. A. , Shanmugarajah P. D. , Sarrigiannis P. G. , Zis P. , Skarlatou V. , Hoggard N. 
Published: June 2020

AbstractImmune-mediated ataxias account for a substantial number of sporadic otherwise idiopathic ataxias. Despite some well-characterised entities such as paraneoplastic cerebellar degeneration where diagnostic markers exist, the majority of immune ataxias remained undiagnosed and untreated. We present here our experience in the treatment of suspected primary autoimmune cerebellar ataxia (PACA) using mycophenolate. All patients reported attend the Sheffield Ataxia Centre on a regular basis and had undergone extensive investigations, including genetic testing using next-generation sequencing, with other causes of ataxia excluded. The diagnosis of PACA was strongly suspected based on investigations, pattern of disease progression, and cerebellar involvement. Patients were treated with mycophenolate and monitored using MR spectroscopy of the cerebellar vermis. Thirty patients with PACA are reported here. Of these, 22 received mycophenolate (group 1). The remaining 8 were not on treatment (group 2-control group). Out of the 22 treated patients, 4 underwent serial MR spectroscopy prior to starting treatment and thus were used as controls making the total number of patients in the control group 12. The mean change of the MRS within the vermis (NAA/Cr area ratio) in the treatment group was + 0.144 ± 0.09 (improved) and in the untreated group − 0.155 ± 0.06 (deteriorated). The difference was significant. We also demonstrated a strong correlation between the spectroscopy and the SARA score. We have demonstrated the effectiveness of mycophenolate in the treatment of PACA. The results suggest that immune-mediated ataxias are potentially treatable, and that there is a need for early diagnosis to prevent permanent neurological deficit. The recently published diagnostic criteria for PACA would hopefully aid the diagnosis and treatment of this entity.
Comment on “Energy levels, oscillator strengths, and transition probabilities for sulfur-like scandium, Sc VI” by El-Maaref et al. [Indian J. Phys. 91 1029 (2017)]
Authors: Aggarwal Kanti M 
Published: June 2020

AbstractIn this comment, through our independent calculations, we assess that the recently reported results of El-Maaref et al. [Indian J. Phys.91 1029 (2017)] for energy levels, oscillator strengths, radiative rates, and lifetimes are inaccurate and unreliable for several levels and transitions of S-like Sc VI.
Comparison of tick-borne encephalitis between children and adults—analysis of 669 patients
Authors: Krawczuk Katarzyna , Czupryna Piotr , Pancewicz Sławomir , Ołdak Elżbieta , Moniuszko-Malinowska Anna 
Published: June 2020

AbstractThe aim of our study was to compare the course of TBE in children and adults. A retrospective analysis of the medical records of 669 patients was performed. The patients were categorized into 2 groups: Group I with 68 children and group II with 601 adults. TBE symptoms in children were milder compared with adults, with meningitis in 97% of cases. In adults, meningoencephalitis and meningoencephalomyelitis made up 49.26% of cases. Nausea and vomiting are more frequent in children, while neurological manifestations are more frequent in adults. There were no differences in CSF pleocytosis at the onset of disease in both groups, while CSF protein concentration was higher in adults. Children treated with corticosteroids over 7 days had higher checkup pleocytosis than pleocytosis at the onset of disease compared with adults. Corticosteroid use prolongs the disease duration but does not influence the development of TBE sequelae. Children had more favourable outcomes than adult patients.
High efavirenz levels but not neurofilament light plasma levels are associated with poor neurocognitive functioning in asymptomatic HIV patients
Authors: Hakkers Charlotte S. , Hermans Anne Marie , van Maarseveen Erik M. , Teunissen Charlotte E. , Verberk Inge M. W. , Arends Joop E. , Hoepelman Andy I. M. 
Published: June 2020

AbstractThe aim of this study is to assess the effect of efavirenz exposure on neurocognitive functioning and investigate plasma neurofilament light (Nfl) as a biomarker for neurocognitive damage. Sub-analysis of the ESCAPE-study, a randomised controlled trial where virologically suppressed, cognitively asymptomatic HIV patients were randomised (2:1) to switch to rilpivirine or continue on efavirenz. At baseline and week 12, patients underwent an extensive neuropsychological assessment (NPA), and serum efavirenz concentration and plasma Nfl levels were measured. Subgroups of elevated (≥ 4.0 mg/L) and therapeutic (0.74 to< 4.0 mg/L) baseline efavirenz concentration were made. Differences between these groups in baseline NPA Z-scores and in delta scores after efavirenz discontinuation were assessed. Nfl level was measured using an ELISA analysis using single molecule array (Simoa) technology. Correlation of plasma NFL with NPA Z-scores was evaluated using a linear mixed model. The elevated group consisted of 6 patients and the therapeutic group of 48. At baseline, the elevated group showed lower composite Z-scores (median − 1.03; IQR 0.87 versus 0.27; 0.79.p0.02). This effect was also seen on the subdomains verbal (p0.01), executive functioning (p0.02), attention (p < 0.01) and speed (p0.01). In the switch group, the elevated group improved more on composite scores after discontinuing efavirenz (mean 0.58; SD 0.32 versus 0.22; 0.54,p0.15). No association between plasma Nfl and composite Z-score was found. High efavirenz exposure is associated with worse cognitive functioning compared with patients with therapeutic concentrations. Plasma Nfl is not a suitable biomarker to measure cognitive damage in this group.
Beyond Data Recovery: Developing Digital Information Systems for Cultural Resources in the Online Era
Authors: Wollwage Lance K. , Brooks Allyson , Smith Rob , McLemore Morgan , Strader Annie , Gant Kim 
Published: June 2020

ABSTRACTFor historic property types such as archaeological sites and historic buildings, data recovery is often the main part of mitigation plans offered by federal agencies with undertakings that will destroy part or all of a cultural resource. In theory, by extracting important information before destruction, we recover some part of a historic resource's cultural value. In some situations, however, data recovery is impossible or otherwise undesirable, and “creative” or off-site mitigation measures are necessary to mitigate adverse effects. In such circumstances, the Washington State Department of Archaeology and Historic Preservation has accepted funding from federal agencies to create, implement, and enhance an online digital information system for cultural resources. This article describes the Washington Information System for Architectural and Archaeological Records Data (WISAARD) and provides an example of a federal agency funding WISAARD development as creative mitigation for the transfer of archaeological sites out of federal ownership. We discuss the benefits of such systems and address how their development meets preservation goals established by the Advisory Council on Historic Preservation.
Automated outbreak detection of hospital-associated pathogens: Value to infection prevention programs
Authors: Baker Meghan A. , Yokoe Deborah S. , Stelling John , Kleinman Ken , Kaganov Rebecca E. , Letourneau Alyssa R. , Varma Neha , O’Brien Thomas , Kulldorff Martin , Babalola Damilola , Barrett Craig , Drees Marci , Coady Micaela H. , Isaacs Amanda , Platt Richard , Huang Susan S. ,   for the CDC Prevention Epicenters Program
Published: June 2020

AbstractObjective:To assess the utility of an automated, statistically-based outbreak detection system to identify clusters of hospital-acquired microorganisms.Design:Multicenter retrospective cohort study.Setting:The study included 43 hospitals using a common infection prevention surveillance system.Methods:A space–time permutation scan statistic was applied to hospital microbiology, admission, discharge, and transfer data to identify clustering of microorganisms within hospital locations and services. Infection preventionists were asked to rate the importance of each cluster. A convenience sample of 10 hospitals also provided information about clusters previously identified through their usual surveillance methods.Results:We identified 230 clusters in 43 hospitals involving Gram-positive and -negative bacteria and fungi. Half of the clusters progressed after initial detection, suggesting that early detection could trigger interventions to curtail further spread. Infection preventionists reported that they would have wanted to be alerted about 81% of these clusters. Factors associated with clusters judged to be moderately or highly concerning included high statistical significance, large size, and clusters involving Clostridioides difficile or multidrug-resistant organisms. Based on comparison data provided by the convenience sample of hospitals, only 9 (18%) of 51 clusters detected by usual surveillance met statistical significance, and of the 70 clusters not previously detected, 58 (83%) involved organisms not routinely targeted by the hospitals’ surveillance programs. All infection prevention programs felt that an automated outbreak detection tool would improve their ability to detect outbreaks and streamline their work.Conclusions:Automated, statistically-based outbreak detection can increase the consistency, scope, and comprehensiveness of detecting hospital-associated transmission.
A NEW PENAL POPULISM? RODRIGO DUTERTE, PUBLIC OPINION, AND THE WAR ON DRUGS IN THE PHILIPPINES
Authors: Kenny Paul D. , Holmes Ronald 
Published: June 2020

AbstractDrawing on evidence from the Philippines, this paper investigates the so-called penal populism thesis. Penal populism refers to an understanding of justice in which criminal and anti-social activity should be harshly punished. The paper tests whether support for harsh penal policies, including the use of extrajudicial killings, is associated with underlying populist attitudes and preferences for charismatic leadership. Since coming to power in 2016, President Rodrigo Duterte has waged a violent and highly popular campaign against drug-related criminality. Based on survey modules fielded in 2016 and 2017, the paper demonstrates a positive relationship between populist attitudes and support for the campaign against illegal drugs in general and the extra-judicial killing of suspected drug users and dealers in particular. It also demonstrates a relationship between belief in the charisma of Duterte and support for the campaign against illegal drugs. The implications of the theory and results for the fields of populism and penal populism research are discussed.
Anti-icing performance of hydrophobic material used for electromechanical drill applied in ice core drilling
Authors: Cao Pinlu , Chen Zhuo , Cao Hongyu , Chen Baoyi , Zheng Zhichuan 
Published: June 2020

AbstractUsing an anti-icing coating to prevent ice accretion on the drill surface is a feasible solution to address the drilling difficulties in warm ice. In this study, four types of commercially available hydrophobic coating materials were tested to evaluate their water repellency and anti-icing properties, namely, a mixture of silica and fluorocarbon resin with polytrifluoroethylene, modified Teflon, silica-based emulsion and an acrylic-based copolymer. Their water contact angles are ~107°, 101°, 114° and 95°, respectively. All these hydrophobic coatings can significantly reduce the strength of the ice adhesion within a temperature range of −10 to −30°C on a planar or curved surface. The coating of an acrylic-based copolymer, in particular, can reduce the average tensile strength and the shear strength of the ice adhesion by 87.08 and 97.11% on planar surfaces at −30°C, and by 98.06 and 96.15% on a curved surface, respectively. The main challenge in the practical application of these coatings is their durability. An acrylic-based copolymer coating will lose its water repellency performance after 140 cycles of abrasion. The shear strength of ice adhered on curved surfaces coated with this material will approach that achieved on uncoated surfaces after 11 cycles of icing and de-icing tests.
Preservice Teachers’ Perceptions of Inclusive Education: The Reality of Professional Experience Placements
Authors: Aprile Kerry Therese , Knight Bruce Allen 
Published: June 2020

AbstractDeveloping the knowledge and practical skills for implementing inclusive education is a legislative and policy imperative for contemporary graduate teachers. In this qualitative study, the authors investigated the experiences of 18 preservice teachers during their practical school placements in primary and secondary school settings and the impact of these experiences on their attitudes towards students with special needs and their readiness to teach in mainstream inclusive settings. Sixteen of the participants had completed 2 or more placements. Data were collected using semistructured interviews and analysed to categorise the observed and enacted practices and define themes that contribute to a deeper understanding of preservice teachers’ learning about inclusion through their practice in schools. The 4 identified themes show that contact, responsibility for instruction, modelled practices, and expectations for student learning all have significant impacts on the quality and outcomes of preservice teachers’ placements. Findings suggest that placement settings do not consistently represent contexts where aspiring teachers are exposed to the types of meaningful contact or successful experiences claimed to be fundamental preparation for inclusive practice. The implications for the preservice teachers themselves and for their future practice are discussed.
Effects ofin ovofeeding of vitamin C on post-hatch performance, immune status and DNA methylation-related gene expression in broiler chickens
Authors: Zhu Yufei , Li Shizhao , Duan Yulan , Ren Zhouzheng , Yang Xin , Yang Xiaojun 
Published: June 2020

AbstractThis study aimed to evaluate the effect ofin ovofeeding (IOF) of vitamin C at embryonic age 11 (E11) on post-hatch performance, immune status and DNA methylation-related gene expression in broiler chickens. A total of 240 Arbor Acres breeder eggs (63 (sem0·5) g) were randomly divided into two groups: normal saline and vitamin C (VC) groups. After incubation, newly hatched chicks from each group were randomly divided into six replicates with ten chicks per replicate. Hatchability, average daily feed intake (D21–42 and D1–42), and average daily gain and feed conversion ratio (D1–21) were improved by vitamin C treatment (P< 0·05). IOF of vitamin C increased vitamin C content (D1), total antioxidant capacity (D42), IgA (D1), IgM (D1 and D21), stimulation index for T lymphocyte (D35) and lysozyme activity (D21) in plasma (P< 0·05). On D21, vitamin C increased the splenic expression of IL-4 and DNMT1 and decreased IL-1β, Tet2, Tet3 and Gadd45βexpression (P< 0·05). On D42, vitamin C increased the splenic expression of IL-4 and DNMT3A and decreased IFN-γ, Tet3, MBD4 and TDG expression (P< 0·05). In conclusion, the vitamin C viain ovoinjection can be absorbed by broiler’s embryo and IOF of vitamin C at E11 improves the post-hatch performance and immune status and, to some extent, the antioxidant capacity of broiler chickens. The expression of enzyme-related DNA methylation and demethylation indicates that the level of DNA methylation may increase in spleen in the VC group and whether the fluctuating expression of pro- and anti-inflammatory cytokines is related to DNA methylation change remained to be further investigated.
Effects of Spirulina platensis on insulin secretion, dipeptidyl peptidase IV activity and both carbohydrate digestion and absorption indicate potential as an adjunctive therapy for diabetes
Authors: Hannan J. M. A. , Ansari Prawej , Azam Shofiul , Flatt Peter R. , Abdel Wahab Yasser H. A. 
Published: June 2020

AbstractSpirulina platensis has been found to be useful in the treatment of type 2 diabetes. The present study aims to elucidate the effects of ethanol extract and butanol fraction of S. platensis on insulin release and glucose homoeostasis in type 2 diabetic rats, together with their mechanism of actions. In vitro and in vivo methods were used including cellular studies to determine potential role of ion channels and cAMP in the insulinotropic actions of the extracts. The ethanol extract and butanol fraction stimulated insulin release from mouse islets and pancreatic β-cells in a concentration-dependent manner. The butanol fraction also similarly stimulated insulin release from perfused rat pancreas. The insulin-releasing action was augmented by glucose, isobutylmethylxanthine, tolbutamide and a depolarising concentration of KCl. The insulin secretory effect was attenuated with diazoxide and verapamil and by omission of extracellular Ca2+. Butanol fraction was found to significantly inhibit dipeptidyl peptidase IV enzyme activity. Moreover, butanol fraction improved glucose tolerance following oral glucose administration (2·5 g/kg body weight (b.w.)). The butanol fraction was tested on 24 h starved rats given an oral sucrose load (2·5 g/kg b.w.) to examine possible effects on carbohydrate digestion and absorption. S. platensis substantially decreased postprandial hyperglycaemia after oral sucrose load and increased unabsorbed sucrose content throughout the gut. During in situ intestinal perfusion with glucose, the butanol fraction reduced glucose absorption and promoted gut motility. Finally, chronic oral administration of butanol fraction for 28 d significantly decreased blood glucose, increased plasma insulin, pancreatic insulin stores, liver glycogen and improved lipid profile. The characterisation of active compounds from butanol fraction revealed the presence of p-coumaric acid, β-carotene, catechin and other antioxidant polyphenols. In conclusion, S. platensis could be an adjunctive therapy for the management of type 2 diabetes.