bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paramagpy: software for fitting magnetic susceptibility tensors using paramagnetic effects measured in NMR spectra
Authors: Orton Henry William , Huber Thomas , Otting Gottfried 
Published: February 2020

Abstract. Paramagnetic metal ions with fast-relaxing electrons generate pseudocontact shifts (PCSs), residual dipolar couplings (RDCs), paramagnetic relaxation enhancements (PREs) and cross-correlated relaxation (CCR) in the nuclear magnetic resonance (NMR) spectra of the molecules they bind to. These effects offer long-range structural information in molecules equipped with binding sites for such metal ions. Here we present the new open-source software Paramagpy, which has been written in Python 3 with a graphic user interface. Paramagpy combines the functionalities of different currently available programs to support the fitting of magnetic susceptibility tensors using PCS, RDC, PRE and CCR data and molecular coordinates in Protein Data Bank (PDB) format, including a convenient graphical user interface. Paramagpy uses efficient fitting algorithms to avoid local minima and supports corrections to back-calculated PCS and PRE data arising from cross-correlation effects with chemical shift tensors. The source code is available from https://doi.org/10.5281/zenodo.3594568 (Orton, 2019).
Faith in Beauty and Progress: Temple Beth El
Authors: Singer Matthew Frederick 
Published: February 2020

ABSTRACT
In the 1920s Harrisburg's acculturated Reform and Conservative Jews found in City Beautiful aesthetics and ideals the architecture and ideology appropriate for expressing publicly their cultural identity as thoroughly modern Americans and Jews. Temple Beth El and Temple Ohev Sholom, both built on Front Street in uptown Harrisburg, stand as the ultimate material outcome and testimony to the synergistic interweaving of early twentieth century American and Jewish progressivism. A book commemorating Temple Beth El's 1928 dedication, produced by J. Horace McFarland's Mount Pleasant Press in 1930, documents in word and image connections between the founding of the congregation, the building of its temple, and the sensibilities and goals of the City Beautiful movement.
Friends of Reform: The Correspondence of J. Horace McFarland and Mira Lloyd Dock
Authors: Elspas Molly , Strange Anna 
Published: February 2020

ABSTRACT
The City Beautiful movement in Harrisburg benefited from the partnership of two key reformers, J. Horace McFarland and Mira Lloyd Dock. A close reading of their correspondence offers insight into the nature of their relationship, their personal views, and reflections on the long-term effects of City Beautiful.
The Brunner Plan for the Harrisburg Capitol Complex
Authors: Gruber Samuel D. 
Published: February 2020

ABSTRACT
In 1915 the commonwealth began a massive urban project providing government offices and a public park to replace the Eighth Ward of Harrisburg just to the east of the Capitol building. The organizing design was the Brunner Plan, created by architect and planner Arnold W. Brunner (1857–1925), a champion of classically inspired civic spaces. The ambitious plan reflected the ideals of the City Beautiful movement and made Harrisburg's Capitol Park one of the best designed capitol complexes in the country.
Look Up, Look Out: Discrepant Stories from the Old Eighth Ward
Authors: Hermeling Andrew Dyrli 
Published: February 2020

ABSTRACT
During the 2018–19 academic year, the author oversaw the research, writing, and production of the Look Up, Look Out project. This collaborative endeavor aims to help visitors and state workers understand the social history of the communities of the Old Eighth Ward, the neighborhood displaced by the Capitol Park expansion beginning in 1911. Telling this story presented the research team with several challenges, including competing narratives and the tension between history and memory, but resulted in a richer history of this important multicultural neighborhood in the heart of the commonwealth's capital.
A fragilidade da população idosa
Authors: Dos Santos Gabrielle Rodrigues , Bjaije Jaqueline Queren , Sabino Luana , De Carvalho Porto Maria Raquel , Alvarenga Pegoraro Vanessa 
Published: February 2020

O desenvolvimento populacional de idosos contribuindo para o aumento de sua vulnerabilidade, decorrente do avanço da idade. Esta revisão relacionou idosos em Instituições de Longa Permanência para Idosos (ILPIs) e com alto índice de depressão, em razão de que essas doenças prejudicam sua qualidade de vida, tornando-os mais vulneráveis a essas situações, por se sentirem totalmente incapazes de enfrentá-las. Sendo assim, esse trabalho tem como objetivo reforçar a importância de profissionais da saúde capacitados para lidar com esses idosos, para que não haja uma piora no quadro clínico ou que leve a óbito por conta dessas doenças.
Produtos de glicação avançada, capacidade funcional e cognitiva em portadores da Doença de Parkinson
Authors: Almeida Jenifer Kristina A. de , Luna Natalia Mariana Silva , Iborra Rodrigo Tallada , Alonso Angélica Castilho , Machado-Lima Adriana 
Published: February 2020

Pode ocorrer na Doença de Parkinson o aumento da formação de proteínas agregadas pela glicação, o que contribui para o declínio da capacidade funcional e cognitiva dos pacientes.
Banco de Vitamina D
Authors: Parreira Karina Eraclea Lara Ferreira , Silva Karla Helena Coelho Vilaça e , Carvalho Gustavo De Azevedo 
Published: February 2020

A popularização de dispositivos móveis, como tablets e smartphones, é percebida atualmente como uma revolução tecnológica de grande impacto. Diante disso percebe-se que o desenvolvimento de soluções computacionais em formato de aplicativos (softwares) para dispositivos móveis apresentam-se como um meio eficaz de disponibilizar conteúdos para atingir grupos públicos-alvo específicos. Uma população bastanteinteressada nessas tecnologias é a população de idosos no Brasil, a qual cresce de maneira vertiginosa. A população de idosos é considerada a mais sensível à hipovitaminose D por inúmeros fatores, principalmente pela falta de exposição solar. Baixos níveis de vitamina D foram associados à perda de massa e força muscular em pacientes idosos, assim com a atrofia muscular, evidenciada em análise histológica de idosos. Odesenvolvimento dessa pesquisa visa desenvolver um protótipo de um aplicativo móvel que auxilie na prevenção da Hipovitaminose D em idosos. O estudo será dividido em três etapas distintas: revisão da literatura referente ao tema proposto; desenvolvimento do aplicativo móvel; avaliação do aplicativo móvel. Quando se desperta o desejo em projetar produtos para essa população, deve-se prezar pela otimização da usabilidade a fim de conduzir a uma maior produtividade e consequente satisfação desse usuário oferecendo a ele a quebra da limitação da mobilidade, recurso fundamental para recursos empregados na assistência à saúde.
Técnicas projetivas na avaliação psicológica com idosos: Revisão de estudos brasileiros (2000-2018)
Authors: De Lima Eduardo Dos Santos , Scortegagna Silvana Alba 
Published: February 2020

O avanço da expectativa de vida da população incide em diversas áreas do conhecimento, inclusive a de avaliação psicológica com métodos que auxiliam a compreensão psicodinâmica da personalidade. A fim de melhor conhecer esta realidade, este estudo buscou verificar as publicações com o uso de técnicas projetivas na população idosa brasileira. A revisão sistemática baseada na Preferred Reporting Items for Systematic Reviews and Meta-Analysis PRISMA, foi usada para analisar artigos publicados entre 2000 e 2018 no Brasil. As bases de dados foram SciELO, PePSIC, Lilacs, BVS e CAPES. Dos 8 estudos incluídos, os instrumentos mais empregados foram técnicas verbais como, método de Zulliger (n=3; 37,5%), e TAT (n=2; 25%). Os estudos com o uso de técnicas projetivas com idosos no Brasil ainda são incipientes, o que deve ser incentivado já que estes instrumentos se mostram importantes ferramentas na avaliação e intervenção, revelando aspectos da estrutura e funcionamento mental.
Ethnopharmacology – active substances and medicines
Authors: G Odontuya 
Published: February 2020

Ethnopharmacological evidence and knowledge of medicinal plants, as well as their traditional usage in folk medicine could become an important guide for discovering and studying their pharmacologically active substances. Of the 122 officially recognized medicinal plant-based medicines worldwide, 80 % are derived from either ethnomedical practice or traditional usages by the local populations. Consequently, this illustrates the effectiveness of identifying active substances from the ethnomedical practices of the related medicinal plants. Today, pharmaceutical companies have started to direct research activities for discovering active compounds from natural sources, including medicinal plants, due to an increase in the lack of precise medications available for treating certain medical complications, as well as a comparatively high level of side effects and toxicity in synthetic medicines.
Угсаатны эм судлал –эмийн идэвхт бодис, шинэ эм бэлдмэлийн эх сурвалж болох нь
Хураангуй: Эмийн ургамлыг уламжлалт анагаах ухаанд хэрэглэдэг талаарх угсаатны эм судлалын мэдлэг, мэдээлэл нь ургамлаас эмчилгээний идэвхтбодисыг ялган судлах, ашиглахадчухал удирдамж болдог. Эмийн ургамлаас гарган авсан 122 бодис нь эм болж дэлхийн эмийн зах зээлд нийлүүлэгдсэн байдаг бөгөөд эдгээрийн 80 % нь тухайн өвчнийг анагаахад орон нутгийн ард түмний хэрэглэж заншсан ургамлаас ялгагдаж, угсаатны эм судлалын судалгааны үр дүнд бүтээгдсэн онцлогтой. Орчин үед зарим өвчний эмчилгээнд тохирох эм бэлдмэл одоо болтол гараагүй, нийлэг эмийн гаж нөлөө, хоруу чанар их зэрэг олон шалтгааны улмаас эмийн компаниуд байгалиас, ургамлаас эмийн идэвхтбодисыг шинээр илрүүлэн эм бэлдмэл гарган авах хандлага, сонирхол улам бүр өсөж байна.
Түлхүүр үг: Ургамал, угсаатны ам судлал, эмийн идэвхт бодис, эм бэлдмэл
Consumo de peixes: uma aplicação da teoria do comportamento planejado
Authors: Nunes Lincoln Pegorari , Dutra Fábio Mascarenhas , Borges João Augusto Rossi 
Published: February 2020

Saúde e bem-estar cada vez mais influenciam decisões de consumo e o peixe por sua vez, recebe um destaque especial neste aspecto. O alimento se destaca pelo valor nutricional quanto à quantidade e qualidade das suas proteínas. Por outro lado, embora estatísticas mostrem expansão no setor brasileiro de pescado, especificamente para a produção de peixe, o consumo per capita não apresenta crescimento na mesma proporção, sendo esta, a carne menos consumida em algumas regiões do país. No Estado de Mato Grosso do Sul, o consumo de peixe está bem abaixo da média nacional per capita, apenas 3,98 kg/habitante/ano. Diante deste cenário, o objetivo deste estudo é investigar se a Teoria do Comportamento Planejado (TCP) poderia prever a intenção para o consumo da proteína peixe em uma amostra de consumidores sul-mato-grossenses. Os resultados fornecem uma compreensão mais clara das intenções de consumo do peixe. Além disso, todos os constructos da TCP original (atitudes, norma subjetiva e controle comportamental percebido) foram preditores significativos da intenção de consumo da proteína. O constructo valores saudáveis foi encontrado como uma importante variável adicional quando se trata do consumo de peixe. Os resultados oferecem ainda, uma variedade de informações úteis para desenvolvimento de novos estudos e a criação de campanhas públicas destinadas a aumentar o consumo da proteína na dieta dos indivíduos.
Aerosols chemical composition, light extinction, and source apportionment near a desert margin city, Yulin, China
Authors: Lei Yali , Shen Zhenxing , Tang Zhuoyue , Zhang Qian , Sun Jian , Ma Yongjing , Wu Xiaoyan , Qin Yiming , Xu Hongmei , Zhang Renjian 
Published: February 2020

Daily PM10and PM2.5 sampling was conducted during four seasons from December 2013 to October 2014 at three monitoring sites over Yulin, a desert margin city. PM10 and PM2.5 levels, water soluble ions, organic carbon (OC), and elemental carbon (EC) were also analyzed to characterize their chemical profiles. bext (light extinction coefficient) was calculated, which showed the highest in winter with an average of 232.95 ± 154.88 Mm−1, followed by autumn, summer, spring. Light extinction source apportionment results investigated (NH4)2SO4 and NH4NO3 played key roles in the light extinction under high RH conditions during summer and winter. Sulfate, nitrate and Ca2 + dominated in PM10/PM2.5 ions. Ion balance results illustrated that PM samples were alkaline, and PM10 samples were more alkaline than PM2.5. High SO42−/K+ and Cl−/K+ ratio indicated the important contribution of coal combustion, which was consistent with the OC/EC regression equation intercepts results. Principal component analysis (PCA) analyses results showed that the fugitive dust was the most major source of PM, followed by coal combustion & gasoline vehicle emissions, secondary formation and diesel vehicle emissions. Potential contribution source function (PSCF) results suggested that local emissions, as well as certain regional transport from northwesterly and southerly areas contributed to PM2.5 loadings during the whole year. Local government should take some measures to reduce the PM levels.
Phase Noise Effects and Mitigation Techniques
Authors: Corvaja Roberto , Armada Ana García 
Published: February 2020

AbstractThe effect of phase noise in 5G is very relevant. With OFDM, correction schemes can combine phase noise reduction and channel estimation. In 5G, the use of multiple‐input‐multiple output requires the extension to MIMO‐OFDM, in particular using zero‐forcing (ZF) and maximum ratio transmission (MRT). The phase noise degradation shows a greater robustness of MRT, although with lower achievable rates, even with imperfect channel knowledge. In massive MIMO, hybrid analog–digital schemes are considered to reduce the complexity and different pre‐coding and combining schemes have different sensitivity to phase noise. The trade‐off between achievable rate and sensitivity to phase noise is shown.
Epidemiology and volume‐outcome relationship of extracorporeal membrane oxygenation for respiratory failure in Japan: A retrospective observational study using a national administrative database
Authors: Muguruma Kohei , Kunisawa Susumu , Fushimi Kiyohide , Imanaka Yuichi 
Published: February 2020

AimTo describe the epidemiology of patients on extracorporeal membrane oxygenation (ECMO) and investigate the possible association between outcomes for respiratory ECMO patients and hospital volume of ECMO treatment for any indications.MethodsUsing data from the Diagnosis Procedure Combination database, a nationwide Japanese inpatient database, between 1 July 2010 and 31 March 2018, we identified inpatients aged ≥18 years who underwent ECMO. Institutional case volume was defined as the mean annual number of ECMO cases; eligible patients were categorized into institutional case volume tertile groups. The primary outcome was in‐hospital mortality. For ECMO patients with respiratory failure, the association between institutional case volume group and in‐hospital mortality rate was analyzed using a multilevel logistic regression model including multiple imputation.ResultsExtracorporeal membrane oxygenation was carried out on 25,384 patients during the study period; of those, 1,227 cases were for respiratory failure. Respiratory cases were categorized into low‐ (<8 cases/year), medium‐ (8–16 cases/year), and high‐volume groups (≥17 cases/year). The overall in‐hospital mortality rate for respiratory ECMO was 62.5% in low‐, 54.7% in medium‐, and 50.4% in high‐volume institutions. With reference to low‐volume institutions, the adjusted odds ratios (95% confidence interval) of the medium‐ and high‐volume institutions for in‐hospital mortality were 0.72 (0.50–1.04; P = 0.082) and 0.65 (0.45–0.95; P = 0.024), respectively.ConclusionsThe present study showed that accumulating the experience of using ECMO for any indications could positively affect the outcome of ECMO treatment for respiratory failure, which suggests the effectiveness of consolidating ECMO cases in high‐volume centers in Japan.
Hydrogenolysis of Polysilanes Catalyzed by Low‐Valent Nickel Complexes
Authors: Pribanic Bruno , Trincado Monica , Eiler Frederik , Vogt Matthias , Comas‐Vives Aleix , Grützmacher Hansjörg 
Published: February 2020

AbstractThe dehydrogenation of organosilanes (RxSiH4−x) under the formation of Si−Si bonds is an intensively investigated process leading to oligo‐ or polysilanes. The reverse reaction is little studied. To date, the hydrogenolysis of Si−Si bonds requires very harsh conditions and is very unselective, leading to multiple side products. Herein, we describe a new catalytic hydrogenation of oligo‐ and polysilanes that is highly selective and proceeds under mild conditions. New low‐valent nickel hydride complexes are used as catalysts and secondary silanes, RR′SiH2, are obtained as products in high purity.
RASS‐Enabled S/P−C and S−N Bond Formation for DEL Synthesis
Authors: Flood Dillon T. , Zhang Xuejing , Fu Xiang , Zhao Zhenxiang , Asai Shota , Sanchez Brittany B. , Sturgell Emily J. , Vantourout Julien C. , Richardson Paul , Flanagan Mark E. , Piotrowski David W. , Kölmel Dominik K. , Wan Jinqiao , Tsai Mei‐Hsuan , Chen Jason S. , Baran Phil S. , Dawson Philip E. 
Published: February 2020

AbstractDNA encoded libraries (DEL) have shown promise as a valuable technology for democratizing the hit discovery process. Although DEL provides relatively inexpensive access to libraries of unprecedented size, their production has been hampered by the idiosyncratic needs of the encoding DNA tag relegating DEL compatible chemistry to dilute aqueous environments. Recently reversible adsorption to solid support (RASS) has been demonstrated as a promising method to expand DEL reactivity using standard organic synthesis protocols. Here we demonstrate a suite of on‐DNA chemistries to incorporate medicinally relevant and C−S, C−P and N−S linkages into DELs, which are underrepresented in the canonical methods.
Multifunctional AuI‐based AIEgens: Manipulating Molecular Structures and Boosting Specific Cancer Cell Imaging and Theranostics
Authors: Zhang Jing , Zou Hang , Lei Jinping , He Benzhao , He Xuewen , Sung Herman H. Y. , Kwok Ryan T. K. , Lam Jacky W. Y. , Zheng Lei , Tang Ben Zhong 
Published: February 2020

AbstractGold(I) N‐heterocyclic carbene (AuI‐NHC) complexes have emerged as potential anticancer agents owing to their high cytotoxicity and stability. Integration of their above unique functions with customized aggregation‐induced emission (AIE) luminogens to achieve specific bioimaging and efficient theranostics to cancer is highly desirable but is rarely studied. Now, a series of novel AuI‐NHC compounds were developed with AIE characteristics. A complex with a PPh3 ligand was selected out as it could achieve both prominent specific imaging of various cancer cells and efficient inhibition of their growth with negligible toxic effects on normal cells due to the targeting binding and strong inhibition towards thioredoxin reductase. This complex could also act as a powerful radiosensitizer to boost the anticancer efficacy with performance superior to that of popularly used auranofin. It holds great potential as a specific and effective theranostic drug in cancer diagnosis and precise therapy.
A Universal Strategy toward Ultrasmall Hollow Nanostructures with Remarkable Electrochemical Performance
Authors: Fan Minmin , Liao Dankui , Aboud Mohamed F. Aly , Shakir Imran , Xu Yuxi 
Published: February 2020

AbstractA facile and versatile microwave‐assisted and shell‐confined Kirkendall diffusion strategy is used to fabricate ultrasmall hollow nanoparticles by modulating the growth and thermal conversion of metal–organic framework (MOF) nanocrystals on graphene. This method involves that the adsorption of microwave by graphene creates a high‐energy environment in a short time to decompose the in situ grown MOF nanocrystals into well‐dispersed uniform core–shell nanoparticles with ultrasmall size. Upon a shell‐confined Kirkendall diffusion process, hollow nanoparticles of multi‐metal oxides, phosphides, and sulfides with the diameter below 20 nm and shell thickness below 3 nm can be obtained for the first time. Ultrasmall hollow nanostructures such as Fe2O3 can promote much faster charge transport and expose more active sites as well as migrate the volume change stress more efficiently than the solid and large hollow counterparts, thus demonstrating remarkable lithium‐ion storage performance.
Facile and Versatile Synthesis of End‐Functionalized Poly(phenylacetylene)s: A Multicomponent Catalytic System for Well‐Controlled Living Polymerization of Phenylacetylenes
Authors: Taniguchi Tsuyoshi , Yoshida Takumi , Echizen Kensuke , Takayama Kokoro , Nishimura Tatsuya , Maeda Katsuhiro 
Published: February 2020

AbstractA rhodium‐based multicomponent catalytic system for well‐controlled living polymerization of phenylacetylenes has been developed. The catalytic system is composed of readily available and bench‐stable [Rh(nbd)Cl]2, aryl boronic acid derivatives, diphenylacetylene, 50 % aqueous KOH, and PPh3. This system offers a method for the facile and versatile synthesis of various end‐functionalized cis‐stereoregular poly(phenylacetylene)s because components from aryl boronic acids and diphenylacetylene were introduced to the initiating end of the polymers. The polymerization reaction shows a typical living nature with a high initiation efficiency, and the molecular weight of the resulting poly(phenylacetylene)s can be readily controlled with very narrow molecular‐weight distributions (Mw/Mn=1.02–1.09). The experimental results suggest that the present catalytic system has a higher polymerization activity than the polymerization activities of other rhodium‐based catalytic systems previously reported.
Ligand‐Enabled β‐Methylene C(sp3)−H Arylation of Masked Aliphatic Alcohols
Authors: Xia Guoqin , Zhuang Zhe , Liu Luo‐Yan , Schreiber Stuart L. , Melillo Bruno , Yu Jin‐Quan 
Published: February 2020

AbstractDespite recent advances, reactivity and site‐selectivity remain significant obstacles for the practical application of C(sp3)−H bond functionalization methods. Here, we describe a system that combines a salicylic‐aldehyde‐derived L,X‐type directing group with an electron‐deficient 2‐pyridone ligand to enable the β‐methylene C(sp3)−H arylation of aliphatic alcohols, which has not been possible previously. Notably, this protocol is compatible with heterocycles embedded in both alcohol substrates and aryl coupling partners. A site‐ and stereo‐specific annulation of dihydrocholesterol and the synthesis of a key intermediate of englitazone illustrate the practicality of this method.
Asymmetric β‐Methylation of l‐ and d‐α‐Amino Acids by a Self‐Contained Enzyme Cascade
Authors: Liao Cangsong , Seebeck Florian P. 
Published: February 2020

AbstractThis report describes a modular enzyme‐catalyzed cascade reaction that transforms l‐ or d‐α‐amino acids to β‐methyl‐α‐amino acids. In this process an α‐amino acid transaminase, an α‐keto acid methyltransferase, and a halide methyltransferase cooperate in two orthogonal reaction cycles that mediate product formation and regeneration of the cofactor pyridoxal‐5′‐phosphate and the co‐substrate S‐adenosylmethionine. The only stoichiometric reagents consumed in this process are the unprotected l‐ or d‐α‐amino acid and methyl iodide.