bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cultural Interpretation: From Method to Methodology
Authors: N.A. Simbirtseva 
Published: March 2020

The method of cultural interpretation is considered as a way to comprehend the processes of culture in their integrity and particular phenomena from the point of their inclusion in the general cultural context. The interpretation underlying the method is a complex procedure of interpretation and comprehension of reality. It is important in research and educational practices. As an alternative, a technique of segmental analysis of the visual image is proposed, which allows to solve general pedagogical tasks.
Keywords: method of cultural interpretation, interpretation, segmental analysis technique, visual image, general pedagogical tasks
Lecturer passion: a pre-requisite for inspirational teaching
Authors: Robson Robert 
Published: March 2020

With reference to the ever-changing landscape within higher education and the issue of marketplace differentiation, it has been suggested that universities need to prioritise the quality of the overall student experience including the quality of classroom teaching (Holbeche 2012). In the light of this, it is evident that institutions of higher education are attempting to address the upskilling of their lecturers through a blend of initiatives. This is important because research studies have shown that students value effective teaching and expect their lecturers to possess a range of key teaching qualities. However, results from student evaluations show that concerns over teaching quality persist. I would argue that the true catalyst for transformational change is the passion for teaching which an individual lecturer personally feels. A lecturer with a genuine passion for teaching will be motivated to continually fine-tune and hone their craft and to seek to perfect the art of teaching. Lecturers who are genuinely passionate for their teaching craft will be driven not only by the satisfaction they derive from their classroom ‘performance’, but also by the eventual learning outcomes for the student. It is the passion for teaching that drives teaching excellence. From the students’ perspective, the ability to inspire is the criterion against which lecturer performance will be measured. Keywords1. Teaching quality2. Inspirational teaching3. Lecturer self-development4. Learning enhancement
Health and health equity among rural poor residents in the context of China’s targeted poverty alleviation policy: evidence from Shaanxi province
Authors: Dai Xiuliang , Wang Lijian , Ren Yangling 
Published: March 2020

Abstract
Background: China’s targeted poverty alleviation policy is having a profound impact on the country’s rural economic and social development now. This study aimed to learn about the health status and health equity of rural poor residents under the implementation of the policy. It further explores the factors affecting the health status and health equity of rural poor residents, in order to contribute to the improvement of the policy.Methods: Data from 1,233 rural poor residents were derived from a questionnaire survey from 12 prefecture-level cities and areas of Shaanxi province in 2017, and a self-evaluation of health was used to reflect the health status. A concentration index was applied to measure the inequity of the health status of rural poor residents. The decomposition method was employed to explore the source of health inequity.Results: The results showed that 44.56% of rural poor residents in Shaanxi province had a poor or very poor health status, which was affected by their economic level, gender, age, the degree of education, and marital status. Additionally, participation in industry development, relocation, health poverty alleviation, and basic living standards were significantly correlated with the health status. The concentration index of the health status of rural poor residents in Shaanxi province was 0.0327. The primary contributors to the health inequity in different regions varied, but the economic level and the degree of education were the most significant factors, and the targeted poverty alleviation policy had a significant impact on the health equity.Conclusions：The results indicated that the health status of rural poor residents in Shaanxi province was generally poor, there was a pro-rich inequity in the health status, and the degree of education and economic level were the primary factors affecting the health status and health equity. The targeted poverty alleviation policy greatly impacted the health status and health equity, and the difference in health status would lead to the inequity of benefits of the targeted poverty alleviation policy. In the future, the policy should focus on ensuring the sustainable development ability of rural residents with poor health status.
The diagnostic value of combined indexes in Acute Renal injury after Cardiopulmonary Bypass Surgery in infants with Congenital Heart Disease
Authors: Yu Haifei , Wang Xinrui , Chen Qiang , Xu Liangpu , Cao Hua 
Published: March 2020

Abstract
Objective: To investigate the incidence and risk factors of acute renal injury (AKI) after cardiopulmonary bypass (CPB) cardiac surgery in infants with congenital heart disease(CHD). Methods: Single-center data from a total of 613 infants with congenital heart disease who underwent cardiothoracic surgery in Fujian Union Hospital.The included patients were divided into two groups according to the occurrence of AKI: AKI group (n = 68) and non-AKI group (n = 92). We obtained clinical data from the electronic hospitalization information system and the laboratory database. All infants were tested for serum creatinine at least twice within 12 hours of admission and after operation. We determined AKI events according to creatinine criteria for improving global prognosis of renal diseases.The general and clinical data of the infants were collected, and the related risk factors were explored by univariate analysis and Logistic regression analysis. Results: 160 patients had congruent lab and echocardiogram data foranalysis. Most of patients are male (56.26%). Original congenital cardiac malformation is similar with our study, the most common is left-to-right shunt CHD(58%), followed by right-to-left shunt CHD(18.75%). All patients showed differences in liver function, renal function, cardiac function and inflammatory indexes within 12 hours of admission and after operation(p<0.05). The AKI group and non-AKI group showed Significant statistical difference in arein age, serum myocardial enzyme , hepatic function, ejection fraction , hemoglobin , platelet count were significantly different meaning (p<0.05). Regression analyses showed that blood oxygen saturation (95%CI 1.003-2.999), CREA(95%CI 1.070-1.253), UREA(95%CI 1.180-3.325), CRP(95%CI 1.006-1.058), BNP(95%CI 0.999-1.000) at 12 hours postoperatively, and in admission to PCT (95%CI 0.461-0.936), Neu(95%CI 0.909-0.995), ALP(95%CI 1.070-1.253) , nadir intraoperative renal regional tissue oximetry to be independent predictors of postoperative kidney damage as measured by blood oxygen saturation, hepatic function, kidney function, cardiac function , Serum myocardial enzyme , inflammatory factor s and blood Routine . Conclusions: Choosing the best age for infants's cardiac surgery, actively preventing preoperative complica- tions, postoperative pneumonia, heart failure and hypoxia play an important role in preventing AKI.
Synergistic bactericidal effect of low-frequency and low-intensity ultrasound combined with levofloxacin-loaded nanoparticles on M. smegmatis in macrophages
Authors: Xie Shuang , Li Gangjing , Hou Yuru , Yang Min , Li Fahui , Li Jianhu , Li Dairong , Du Yonghong 
Published: March 2020

Abstract
Purpose Tuberculosis is a highly infectious disease caused by Mycobacterium tuberculosis (Mtb) which often parasites in macrophages. The present study was to investigate the bactericidal effect and underlying mechanisms of low-frequency and low-intensity ultrasound (LFLIU) combined with levofloxacin-loaded nanoparticles (LEV-NPs) on M. smegmatis (a surrogate of Mtb )in macrophages. Methods and results LEV-NPs were prepared by a double emulsiﬁcation method. The characterization, such as average diameter, zeta potential, polydispersity index and morphology, and in-vitro drug release efficiency of LEV-NPs were investigated. M. smegmatis in macrophages was treated by LEV-NPs combined with 42 kHz ultrasound irradiation at an intensity of 0.13 W/cm 2 for 10 min. The results showed ultrasound could significantly promote phagocytosis of nanoparticles by macrophages ( p <0.05), further ultrasound combined with LEV-NPs could promote the production of macrophage ROS, and the apoptosis rate of macrophages was significantly higher than that of the control ( p <0.05). Transmission electronic microscope showed M. smegmatis cell wall was ruptured, the cell structure was incomplete, and the bacteria received severe damage in the ultrasound combined with the LEV-NPs group. Activity assays showed that ultrasound combined with LEV-NPs exhibited 10-fold higher antibacterial activity against M. smegmatis residing inside macrophages compared with free drug. Conclusion Our data demonstrate that ultrasound combined with LEV-NPs have a great potential to therapy of tuberculosis.
Identifying Muscle Growth-Related Genes of Mandarin Fish (Siniperca chuatsi) by Transcriptome, and Exploring the Expression in Different Sizes and Compensatory Growth
Authors: Liu Xuange , Zeng Shuang , Liu Shuang , Wang Gongpei , Lai Han , Zhao Xiaopin , Bi Sheng , Guo Dingli , Chen Xiaoli , Yi Huadong , Su Yuqing , Li Guifeng 
Published: March 2020

Abstract
BackgroundHow organisms display many different biochemical, physiological processes through genes expression and regulatory mechanisms affecting muscle growth is a central issue in growth and development. In Siniperca chuatsi, the growth-related genes and underlying relevant mechanisms are poorly understood, especially for difference of body sizes and compensatory growth performance. ResultsThe muscle from different sizes of individuals was subjected to transcriptome analysis by RNA-sequencing. Results showed that 8,942 different expression genes (DEGs) were identified after calculating the RPKM. The DEGs involved in GH-IGF pathways, protein synthesis, ribosome synthesis and energy metabolisms, which were expressed at higher level in small individuals (S), whereas in the large fish (L) little expression was found. In repletion feeding and compensatory growth experiments, 8 more significant DEGs were used for further research (GHR2, IGFR1, 4ebp, Mhc, Mlc, Myf6, MyoD, troponin), and this research revealed different temporal and spatial expression patterns of these genes. When food was plentiful, 8 genes participated in and promoted the growth and muscle synthesis, respectively. Starvation can be shown to inhibit the expression of Mhc, Mlc and troponin, and high expression of GHR2, IGFR1 and 4ebp inhibited growth. MyoD can sense and regulate the hunger and work with Mhc and Mlc to accelerate the compensatory growth of S.chuatsi. ConclusionsThis study is helpful to understand the regulation mechanisms of muscle growth-related genes. The elected genes will contribute to the selective breeding in future as candidate genes.
High Resolution Melting Analysis in Leishmania Resistance: The Role of Multi Drug Resistance 1 Gene
Authors: Abadi Maryam Fekri Soofi , Moradabadi Alireza , Vahidi Reza , Rad Iman , Dabiri Shahriar 
Published: March 2020

Abstract
Objective Pentavalent antimonial compounds are currently used to treat Leishmaniasis. Resistance to these drugs is a serious problem. The purpose of this study was to evaluate the mutations in the multi-drug resistance 1 (MDR1) gene in biopsy specimens of Leishmania Tropica with high resolution melting (HRM) method.Results In this experimental study, genomic DNA was extracted from 130 patients with skin Leishmaniasis. Then, nucleotide changes were investigated throughout the gene length using HRM and sequencing methods. The results of the nucleotide changes showed that 61% of the samples that were unresponsive to drug had mutations in the MDR1 gene in different groups, which were confirmed by the sequencing method. These mutations can be one of the factors responsible for non-response to the treatment of the disease. HRM method can be used to diagnose drug resistance in Leishmaniasis. It is also recommended that further studies be done regarding the importance of drug resistance in the affected patients.
Demonstration of the temporal evolution of serum markers of skeletal muscle ischaemia reperfusion injury - An observational clinical study.
Authors: GOONERATNE THUSHAN DHANANJA , Homer-Vanniasinkam Shervanthi , Wijeyaratne Serosha Mandika 
Published: March 2020

Abstract
Objective The study aimed to investigate the temporal evolution of markers of skeletal muscle ischaemia reperfusion injury (IRI) to shed more light into its pathogenesis towards finding a clinical therapeutic intervention. P-selectin, Myeloperoxidase and TNF-alpha were selected as markers of IRI based on their role in its pathogenesis. An observational study was conducted on patients with skeletal muscle ischaemia requiring revascularization. Loco-regional venous sampling was performed at 0, +2, +4, +6, +12 and +24 hours post-reperfusion to demonstrate the temporal evolution of surrogate markers of IRI.Results Levels of P-Selectin, Myeloperoxidase and TNF-alpha demonstrated a significant peak elevation during 2h - 4h following reperfusion when compared to baseline values. (P-selectin 59.48pg/ml to 125.91pg/ml, p=0.008; Myeloperoxidase 78.84pg/ml to 116.86pg/ml, p=0.051; TNF-alpha 1.80pg/ml to 34.53pg/ml, p=0.002) All three markers gradually subsided with time and reached baseline pre-perfusion values between 6h – 8h from time of reperfusion. The study suggests that skeletal muscle IRI in humans is associated with an early exaggerated pro-inflammatory response, as supported by increased expression of reperfusion injury markers in the venous effluent. They demonstrate potential for use as markers of IRI for future clinical trials.
Patterns And Correlates Of Substance Use: Cross Sectional Exploratory Study Among Health Care Workers In Bungoma County, Kenya
Authors: Kolongei Titus Kipchirchir , Osero Justus , Gachau Albert 
Published: March 2020

Abstract
Background: This was a cross sectional exploratory study that examined data obtained from health care workers on substance use in Bungoma County Kenya. Methods: This was a cross sectional exploratory study in selected health facilities in three sub counties of Bungoma County. This study used a two-stage cluster sampling technique and systematic sampling to select the respondents. The study sample was (N= 237 ) among health care workers in selected facilities in 3 sub counties of Bungoma county .The study response rate was 96.3 %(237/247) . Self-reported data on substance use during their lifetime, use in the past 12 months and past 30 days was used as key parameters to determine patterns and correlates of substance Results: As compared with females, males were found to have a greater like hood of substance use, having family member with a history of substance use and a colleague who uses substances were key predictors for substance use. Substance use prevalence without generalization to the population of Health care workers (HCWs) in this study shows a high prevalence of lifetime substance use (35.02, 29.17- 41.36) concurs with findings in a study in Machakos and Nairobi (Mokaya et al 2018). Alcohol had the highest lifetime prevalence rate (33%) Conclusion; Alcohol use among HCW had the highest prevalence with socio-demographic factors on gender, family and peer influence associated with substance use among health workers. The study findings suggest preventive interventions against substance use are required at family level and among peers. Further research is needed on substance abuse, dependence, reasons for substance use and how it affects health workers performance Keywords: Substance Use, abuse, dependence, patterns, correlates, lifetime use
Postpartum Depression and Anxiety among Lebanese women: correlates and scales validation
Authors: Hobeika Eva , Outayek Miguella , Malaeb Diana , Hobeika Elie , Salameh Pascale , Kheir Nelly , Obeid Sahar , Sleiman Zaki , Barakat Habib , Hallit Souheil 
Published: March 2020

Abstract
Background The last study conducted in Lebanon about postpartum depression dates back to 2014, whereas no studies have been conducted to assess postpartum anxiety (PPA). The shortage of research in this field and the potential opportunities to provide different aspects of postpartum care that respond to women's needs require a deeper understanding of the various problems faced by postpartum women. The study objectives were to delineate some factors associated with postnatal depression and anxiety among a sample of Lebanese women 4-6 weeks after delivery and validate the Edinburgh Postnatal Depression Scale (EPDS) and Perinatal Anxiety Screening Scale (PASS) in Arabic language in that sample.Methods This cross-sectional study, carried out between July 2018 and March 2019, enrolled 295 participants who came for a postnatal checkup to four clinics.Results Higher postpartum anxiety (Beta=0.25), higher insomnia (Beta=0.11) and having complications during delivery (Beta=1.81) were associated with higher postpartum depression. Higher postpartum depression score (Beta=1.38) and a premature baby birth compared to those born at term with normal weight (Beta=4.25) were associated with higher postpartum anxiety. The factor analysis for the EPDS and the PASS scales was run over the whole sample. The EPDS and PASS scales items converged over a solution of three and seven factors that had an Eigenvalue over 1 respectively, explaining a total of 64.73% and 65.12% of the variance respectively. High Cronbach’s alpha values were found for the EPDS (0.826) and PASS (0.920) scales.Conclusion Depression and anxiety prevalence rates in the Lebanese population is higher compared to other countries which may in part be due to differences of regional, social, and environmental culture. Different etiological factors could contribute to both depression and anxiety in the postpartum period, which could adversely affect both the mother and the infant.
Integrated analysis profiles of long non–coding RNAs reveal potential biomarkers across brain regions in post–traumatic stress disorder
Authors: Bian Yaoyao , Yang Lili , Wang Zhongli , Li Wen , Wang Qing , Zhang Bin , Zhao Min , Wang Long , Zhi Yicheng , Xu Guihua 
Published: March 2020

Abstract
Background Post–traumatic stress disorder (PTSD) is characterized by impaired fear extinction, excessive anxiety and depression. However, underlying mechanisms, especially the function roles of long non–coding RNAs (lncRNAs) involved in PTSD is still unclear. We argued that the lncRNAs, co–expressed mRNAs, as well as the associated pathways, are altered and may thus serve as potential biomarkers and key pathways related to PTSD.Methods The gene expression profiles of GSE68077 was downloaded from the GEO database, and the differentially expressed lncRNAs and mRNAs were identified. Gene ontology (GO) and Kyto Encyclopedia of Genes and Genomes pathway (KEGG) enrichment analysis were performed. Subsequently, protein–protein interaction (PPI) network was analyzed, and module analysis of the differentially expressed mRNAs was performed with Cytoscape software. Finally, lncRNAs–mRNAs co–expression network was constructed and core pair lncRNAs involved in PTSD were mapped.Results A total of 45 differentially expressed lncRNAs and 726 differentially expressed mRNAs were obtained. Among of which, 17 lncRNAs and 86 mRNAs were inter–regulated, and most of the lncRNAs–mRNAs co–expression showed positive correlations. The lncRNAs–mRNAs co–expressed network suggested the potentially functional roles of lncRNAs, regulated mRNAs and related pathways in PTSD. By implication of the core pair network, lncRNA–NONMMUT010120.2 synergistically up–regulated Ppargc1a and down–regulated Cir1, Slc38a9, Atp6v0a2. Moreover, lncRNA–NONMMUT023440.2, NONMMUT034155.2, NONMMUT105407.1 and NONMMUT149972.1 were co–expressed with 10 co–expressed mRNAs, which indicated that lncRNAs involved in PTSD might work by regulating the co–expressed mRNAs.
Factors Associated with the Use of Primary Care Centres in Persons with Schizophrenia
Authors: Anguiano MCarmen Castillejos , Pérez Carlos Martín , Aragon Antonio Bordallo , Küstner Berta Moreno 
Published: March 2020

Abstract
Background. Patients with schizophrenia and related disorders have more physical problems than the general population. Primary care professionals play an important role in the care of these patients as they are the main entry point into the healthcare system. We aimed to identify patient, general practitioner, and primary care centre factors associated with the number of visits of patients with schizophrenia and related disorders to general practitioners. Methods. A descriptive, cross-sectional study was conducted in 13 primary care centres belonging to the Clinical Management Unit of Mental Health of the Regional Hospital of Málaga, Spain. The eligible population was composed of patients with schizophrenia and related disorders attending these primary care centres in the study area. Our dependent variable was the total number of general practitioner visits made by patients with schizophrenia and related disorders during the 3.5-year observation period. The independent variables were grouped into three: a) patient variables (sociodemographic and clinical), b) general practitioner variables, and c) primary care centre characteristics. Descriptive, bivariate, and multivariate analyses using the random forest method were performed. Results. A total of 259 patients with schizophrenia and related disorders, 96 general practitioners, and 13 primary care centres were included. The annual mean was 3.9 visits per patient. The results showed that general practitioner age, patient gender, patient marital status, primary care centre to which the patient belonged, taking antipsychotic medication, presenting any cardiovascular risk factor, and frequency of mental health training sessions at the primary care centre were associated with an increased number of visits to general practitioners. Conclusions. The only general practitioner characteristic that was associated with the number of visits was age. There were also patient variables involved in the number of visits. Finally, mental health training for general practitioners was important for these professionals to manage patients with schizophrenia and related disorders.