Malignant Hyperthermia and Gene Polymorphisms Related to Inhaled Anesthesia Drug Response
Authors: Thi Thu Hang Vu , Thi Thu Mau Nguyen , Tran Thuy Nguyen , Ngoc Thanh Le , Thi Hong Nhung Nguyen , Doan Long Dinh , Thi Thu Hoai Nguyen , Thi Thom Vu 
Published: March 2020

Malignant hyperthermia (MH) is a clinical response happened to patient who is sensitive with inhaled anesthesia drug that could cause suddently death. Many previous studies showed that malignant hyperthermia strongly related to genetic background of patients including RYR1, CACNA1S or STAC3 gene polymorphisms. With the development of high technology such as next generation sequencing, scientists found that 37 to 86 percents of MH cases had RYR1 mutations and approximately 1 percent of those had CACNA1S mutations. Gene analysis testing was recommended to apply for patient with MH medical history or MH patient’s family relations.
Keywords
Malignant hyperthermia, inhaled anesthesia, RYR1, CACNA1S, STAC3.
References
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