bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and In Silico Outcomes of the Expression of miR-130a-5p and miR-615-3p in Tumor Compared with Non-Tumor Adjacent Tissues of Patients with BC
Authors: Ilkhani Khandan , Delgir Soheila , Safi Asma , Seif Farhad , Samei Azam , Bastami Milad , Alivand Mohammad Reza 
Published: September 2020

Background:
Breast Cancer (BC) is the most common malignancy among women with a high mortality
rate. The blockade of asparagine-related pathways may be an effective measure to control the progression
and reduction of BC metastasis potential. Recently, it has been shown that various miRNAs, as part of small
non-coding RNAs, have a great role in cancer development, especially asparagine-related pathways, to modulate
the invasiveness.

Objective:
This study aimed to evaluate the expression of miR-130a-5p and miR-615-3p in tumoral and nontumoral
adjacent tissues of patients with BC.

Methods:
There is a chance that asparagine metabolism is influenced by miR-130a-5p and miR-615-3p as confirmed
by bioinformatics analysis. Hence, real-time PCR was conducted on eighty BC tumoral and non-tumoral
adjacent tissues to evaluate the expression level of the two miRNAs. To predict the potential biological process
and molecular pathways of miR-130a-5p, an in silico analysis was performed.

Results:
This study indicated that miR-130a was downregulated in tumoral tissues compared to non-tumoral
adjacent tissues (P-value= 0.01443 and fold change= -2.5137), while miR-615-3p did not show a significant
difference between the two groups. Furthermore, the subgroup studies did not reveal any significant correlation
between the expression of these two miRNAs and subfactors. Furthermore, in silico studies unraveled several
biological processes related to amino-acid metabolism, as well as pathways related to tumor development such
as Phosphatase and Tensin Homolog (PTEN) and JAK-STAT pathways among miR-130a-5p target genes.

Conclusion:
Our findings indicate that miRNA-130a-5p is downregulated in BC tissues and may play a tumor
suppressor role in patients with BC. Therefore, it may be suggested as a potential diagnostic and therapeutic
target for BC.
Perceptions, Practices, and Challenges of Formative Assessment in Initial Nursing Education
Authors: Lajane Halima , Gouifrane Rachid , Qaisar Rabia , Chemsi Ghizlane , Radid Mohamed 
Published: September 2020

Background:
Formative assessment is a pedagogical practice that improves teaching, as well as students' learning. There is a multitude of research demonstrating interest in this practice in the field of education. However, this assessment practice is poorly integrated by teachers despite its great pedagogical potential, in addition to the tensions existing between formative and summative assessment that its implementation is more formal by the institutions.

Objective:
The purpose of this research is to explore, as a first step, how nursing teachers conceptualize formative assessment and how they judge its usefulness in the teaching/learning process. Secondly, the study seeks to identify the main challenges that could influence the practice of formative assessment in the context of nursing education.

Methods:
The study used a descriptive quantitative research design. The target population of the study was composed of nursing teachers (N = 50) from the Higher Institute of Nursing and Health Techniques of Casablanca (ISPITS).
This target population includes all permanent nursing teachers working at the ISPITS of Casablanca, divided into the various existing fields. They are responsible for the initial training and practical supervision of nursing students and health technicians enrolled in the cycles of the professional license.
To meet our research objective, we conducted a survey using a questionnaire with 37 items divided into five dimensions based on William and Thompson's (2007) model of formative assessment.

Results:
The results revealed that, in teachers’ practice, the informal approach to formative assessment takes precedence over formal approaches based on planned assessment tools. In addition, their perception of the usefulness of formative assessment is oriented towards a diagnostic function of students' learning difficulties rather than a function of teaching guidance.
Furthermore, the study showed that the time commitment of formative assessment and the diversity of activities required of teachers might be obstacles to a broader practice of formative assessment.

Conclusion:
This study offers suggestions that may help teachers facilitate and innovate the implementation of formative assessment in the field of nursing. Our research perspective is to demonstrate the effect of formative assessment on student learning outcomes through the implementation of a field experiment in collaboration with nursing teachers.
Soil Unconfined Compressive Strength Prediction Using Random Forest (RF) Machine Learning Model
Authors: Ly Hai-Bang , Thai Pham Binh 
Published: September 2020

Aims:
Understanding the mechanical performance and applicability of soils is crucial in geotechnical engineering applications. This study investigated the possibility of application of the Random Forest (RF) algorithm – a popular machine learning method to predict the soil unconfined compressive strength (UCS), which is one of the most important mechanical properties of soils.

Methods:
A total number of 118 samples collected and their tests derived from the laboratorial experiments carried out under the Long Phu 1 power plant project, Vietnam. Data used for modeling includes clay content, moisture content, specific gravity, void ratio, liquid limit and plastic limit as input variables, whereas the target is the UCS. Several assessment criteria were used for evaluating the RF model, namely the correlation coefficient (R), root mean squared error (RMSE) and mean absolute error (MAE).

Results:
The results showed that RF exhibited a strong capability to predict the UCS, with the R value of 0.914 and 0.848 for the training and testing datasets, respectively. Finally, a sensitivity analysis was conducted to reveal the importance of input parameters to the prediction of UCS using RF. The specific gravity was found as the most affecting variable, following by clay content, liquid limit, plastic limit, moisture content and void ratio.

Conclusion:
This study might help in the accurate and quick prediction of the UCS for practice purpose.
Intelligence Prediction of Some Selected Environmental Issues of Blasting: A Review
Authors: Murlidhar Bhatawdekar Ramesh , Armaghani Danial Jahed , Mohamad Edy Tonnizam 
Published: September 2020

Background:
Blasting is commonly used for loosening hard rock during excavation for generating the desired rock fragmentation required for optimizing the productivity of downstream operations. The environmental impacts resulting from such blasting operations include the generation of flyrock, ground vibrations, air over pressure (AOp) and rock fragmentation.

Objective:
The purpose of this research is to evaluate the suitability of different computational techniques for the prediction of these environmental effects and to determine the key factors which contribute to each of these effects. This paper also identifies future research needs for the prediction of the environmental effects of blasting operations in hard rock.

Methods:
The various computational techniques utilized by the researchers in predicting blasting environmental issues such as artificial neural network (ANN), fuzzy interface system (FIS), imperialist competitive algorithm (ICA), and particle swarm optimization (PSO), were reviewed.

Results:
The results indicated that ANN, FIS and ANN-ICA were the best models for prediction of flyrock distance. FIS model was the best technique for the prediction of AOp and ground vibration. On the other hand, ANN was found to be the best for the assessment of fragmentation.

Conclusion and Recommendation:
It can be concluded that FIS, ANN-PSO, ANN-ICA models perform better than ANN models for the prediction of environmental issues of blasting using the same database. This paper further discusses how some of these techniques can be implemented by mining engineers and blasting team members at operating mines for predicting blast performance.
Penerapan IoT untuk Sistem Pemantauan Lampu Penerangan Jalan Umum
Authors: Adam Adam , Muharnis Muharnis , Ariadi Ariadi , Lianda Jefri 
Published: September 2020

Penerangan jalan umum (PJU) digunakan untuk menerangi jalan, sehingga pengguna jalan mendukung kenyamanan dan keselamatan dimalam hari. Terdapat keterbatasan sistem pemeriksaan dan pelaporan kerusakaan lampu PJU. Artikel ini membahas penerapan teknologi Internet of Things (IoT) untuk memantau gangguan kerusakan pada lampu PJU. Metode yang digunakan dalam pengembangan sistem pemantauan tersebut yaitu, kajian literatur, analisis kebutuhan, perancangan, pembuatan dan pengujian. Sistem ini dilengkapi dengan sensor ZMPT101B, ACS 712, dan Modul WiFi ESP 8266-01. Sensor ZMPT101B digunakan untuk mengukur nilai tegangan PLN, sedangkan sensor ACS 712 merupakan sensor yang digunakan untuk mengukur arus pada lampu jalan. ESP8266-01 merupakan modul wifi yang dapat terhubung langsung dengan WiFi dan membuat koneksi TCP/IP sehingga dapat mengirim data dari mikrokontroler Arduino Mega2560 ke internet. Sistem pemantauan lampu PJU ini kemudian dapat diakses menggunakan antarmuka ThingSpeak baik dengan ponsel maupun laptop. Hasil pengujian sensor tegangan menunjukan tingkat akurasi sebesar 96,7%, parameter tegangan dan arus lampu ditampilkan dalam bentuk grafik dan indikator. Hasil tersebut menunjukkan bahwa sistem dapat digunakan untuk memantau kondisi lampu PJU. Hal tersebut dapat dijadikan sebagai dasar pengembangan sistem selanjutnya berbasis sistem cerdas untuk mendukung lampu PJU sesuai SNI dan memiliki efisiensi energi.
Proinflammatory cytokines in patients with acute myocardial infarction against the background of chronic obstructive pulmonary disease
Authors: Naumov A. V. , Prokofieva T. V. , Polunina O. S. , Saroyants L. V. , Polunina E. A. 
Published: September 2020

Objective: To study and analyze serum levels of interleukins (IL): IL-1β, IL-2 and IL-6 in patients with myocardial infarction and chronic obstructive pulmonary disease.Materials and methods: In 85 people were examined: 28 patients with myocardial infarction, 37 patients with comorbid pathology (myocardial infarction and chronic obstructive pulmonary disease) and 20 somatically healthy volunteers as a control group. Determination of IL-1β, IL-2 and IL-6 levels was basing on enzyme immunoassay.Results: The median and inter-percentile range of IL-1β, IL-2 and IL-6 in the donors did not differ significantly from the data of the manufacturer. In the group of patients with myocardial infarction and in patients with comorbid pathology a statistically significant increase in the level of median and inter-percentile range of cytokines was revealing compared with the control group. The highest levels of IL-1β, IL-2 and IL-6 were detecting in the group of patients with comorbid pathology. IL-6 was found to be an independent marker of increased risk of STEMI and an increase in its concentration later than 12 hours after hospitalization is associated with the risk of future cardiovascular death or new myocardial infarction.Conclusion: Analysis of the dynamics of the level of IL-1β, IL-2 and IL-6 has a high prognostic value in patients with myocardial infarction and in patients with comorbid pathology.
Transparency and Accountability Based on The Concept of “Pada Gelahang” Enhancing Village Financial Management
Authors: Budiasni Ni Wayan Novi , Ayuni Ni Made Sri 
Published: September 2020

Along with the increase in the amount of village funds and the efforts to decrease the mismanagement carried out by the government, the Government strives to defend the WTP opinion by adapting local wisdom in managing finances. This study aims to analyze the variables of transparency and accountability based on the concept of pada gelahang in the village financial management. The research was a quantitative with SEM (Structural Equation Modelling) analysis tool and using PLS (Partial Least Square) method. The sample of this study is 57 Village in Buleleng Regency. The results showed that transparency had an effect on the management of village finances (tcount >ttable = 3,501>1,960) and accountability had an effect on the management of village finances (tcount >ttable = 5,571>1,960). Thus, it is found that transparency and accountability based on the concept of pada gelahang have an effect on village financial management. The concept of the pada gelahang has the meaning of equality, togetherness and mutual assistance reflected in the financial management of the village that is transaparan and accountable.
Estudo do perfil epidemiológico da tuberculose em Araraquara, SP, no período 2012 - 2017
Authors: Bonini Eduardo Henrique , Massabni Antonio Carlos 
Published: September 2020

Introdução: A tuberculose (TB) afeta 1/3 da população mundial e cerca de 10 milhões de pessoas desenvolvem TB a cada ano, resultando em mais de dois milhões de mortes. Objetivos: O principal objetivo deste trabalho é apresentar um estudo do perfil epidemiológico da TB em Araraquara (SP) e comparar o perfil epidemiológico da TB em Araraquara com os padrões da doença no mundo, Américas, Brasil e Estado de São Paulo. Método: As pesquisas e informações foram coletadas do relatório anual da Organização Mundial da Saúde (OMS), do Ministério da Saúde do Brasil, da Secretaria do Estado de São Paulo, da Secretaria Municipal de Saúde e do Serviço Especial de Saúde de Araraquara (SESA). O período de 2012 a 2017 foi analisado considerando-se as projeções das metas da OMS para o fim da TB de 2015 a 2035. Resultados: Todos os dados apresentados, com exceção da cidade de Araraquara, estão acima da projeção requerida pela OMS. Embora ligeiramente abaixo da projeção citada, Araraquara está se encaminhando para reduzir a incidência de TB até o ponto de erradicar a doença. conclusões: Os baixos níveis atuais de infecção por TB em Araraquara podem ser explicados por fatores como, um dos maiores Índices de Desenvolvimento Humano (IDH) do País, a existência de um sanatório especializado no tratamento da doença, políticas públicas e uma eficiente rede de informações sobre TB . Araraquara pode ser um modelo no combate à doença no nível nacional e erradicar a doença até antes do prazo estabelecido pela OMS.
Província e metrópole na tessitura poética drummondiana
Authors: Santos Valci Vieira dos 
Published: September 2020

A poética drummondiana é esse emaranhado de possibilidades temáticas e leituras plúrimas. Emerge dele o decantado bloco temático Província/Metrópole. Dentre os inúmeros escritores que se debruçaram sobre a obra de Carlos Drummond de Andrade, evidencia-se Affonso Romano de Sant’Anna. Pretendemos, com este trabalho, fazer uma releitura da leitura de Sant’Anna acerca da poesia dialética do poeta mineiro, que se desdobra em três momentos: “Eu maior que o Mundo”, “ Eu menor que o Mundo” e “Eu igual ao Mundo”.
ANALYSIS OF THE CHANGES MADE IN THE OFFICIAL GAME RULES OF VOLLEYBALL THROUGH THE DOCUMENT ANALYSIS METHOD
Authors: Uluöz Eren 
Published: September 2020

The purpose of this study is to set forth the changes made in the purposes of rule changes. The document analysis method, one of the qualitative analysis methods based on the collection of data by examining the existing records and documents, has been used in this study. It has been noted upon examining the findings attained as a result of the analysis that the major rule changes made could be mainly grouped under six headings. These may be listed as, “improvement of the playing court and physical conditions”, “protection of player health”, “increasing game continuity by reducing interruptions”, “enhancing spectator pleasure by increasing rally durations”, “increasing TV broadcasts” and “standardization between volleyball and beach volleyball”. In spite of the positive developments, there are players, trainers, spectators and sports commentators who believe that certain changes such as “partial freedom in the net contact and crossing over to opponent’s court” however, might increase player injuries although they increase game continuity.
Pengalaman ibu hamil primigravida dengan riwayat menikah usia dini
Authors: Purnama Nur , Immawanti Immawanti , Masniati Masniati , Fitriani Lina 
Published: September 2020

Pendahuluan:Kehamilan usia dini merupakan kehamilan yang terjadi pada remaja putri berusia kurang dari 20 tahun. Tujuan penelitian ini untuk mengetahui pengalaman ibu hamil primigravida dengan riwayat menikah usia muda di wilayah kerja Puskesmas Kecamatan Wonomulyo. Metode:Desain penelitian fenomenologi, partisipan yaitu ibu hamil primigravida dengan riwayat menikah usia muda di wilayah kerja Puskesmas Kecamatan Wonomulyo, pengumpulan data dengan teknik wawancara mendalam kemudian data dianalisa dengan menggunakan model Miles and Huberman. Hasil: Pengalaman ibu primigravida dengan riwayat menikah usia dini di wilayah kerja Puskesmas Kecamatan Wonomulyo mengalami perubahan dalam berbagai aspek yaitu perubahan fisik, psikologis, sosial, budaya, dan spiritual. Simpulan: Perubahan yang terjadi pada primigravida dipengaruhi oleh peran dan dukungan dari suami, keluarga, dan tenaga kesehatan. Partisipan dalam penelitian ini juga memiliki persepsi positif dan negatif dalam masa kehamilannya.Diharapkan instansi terkait dapat memberikan perhatian lebih terhadap permasalahan selama kehamilan primigravida khususnya bagi ibu hamil usia muda.
PEMBINAAN LITERASI DAN BAHASA SANTUN MELALUI TUJUH PILAR BUDAYA CIANJUR
Authors: Maryam Siti , Mauludi M. Abdillah Al , Martiadi M. Dani , Baskoro Fikky , Miftahulfalah Abdulkholiq , Munawar Cep Muhamad 
Published: September 2020

Penggunaan bahasa tidak santun telah menimbulkan konflik sosial bahkan sampai masuk ke ranah hukum. Meskipun peristiwa itu terjadi di kalangan remaja dan dewasa, namun menyediakan payung sebelum hujan akan lebih baik. Alasan itulah yang melatarbelakangi kegiatan pengabdian kepada masyarakat berupa pembinaan literasi dan bahasa santun di Sekolah Dasar Islamic Center Cianjur. Kegiatan ini diawali dengan observasi penggunaan bahasa siswa di luar dan di dalam kelas. Hasil observasi menunjukkan bahwa para siswa masih belum sepenuhnya berbahasa dan berperilaku santun sehingga pembinaan bahasa santun ini mengaitkannya dengan tujuh pilar budaya Cianjur, karena pilar Ngaos (mengaji/membaca/literasi) dan, Someah (santun) erat kaitannya dengan kajian Program Studi Pendididkan Bahasa dan Sastra Indonesia. Metode simulasi dan bermain peran digunakan dalam kegiatan ini. Hasilnya para siswa dapat menggunakan bahasa Indonesia santun sehingga menambah pengguna bahasa Indonesia santun, baik di dalam kelas maupun di luar kelas meskipun masih terjadi campur kode, antara bahasa Indonesia dengan bahasa Sunda. Meskipun begitu, penggunaan bahasa siswa tetap santun.
Repeat convection-enhanced delivery for diffuse intrinsic pontine glioma
Authors: Bander Evan D. , Ramos Alexander D. , Wembacher-Schroeder Eva , Ivasyk Iryna , Thomson Rowena , Morgenstern Peter F. , Souweidane Mark M. 
Published: September 2020

OBJECTIVEWhile the safety and efficacy of convection-enhanced delivery (CED) have been studied in patients receiving single-dose drug infusions, agents for oncological therapy may require repeated or chronic infusions to maintain therapeutic drug concentrations. Repeat and chronic CED infusions have rarely been described for oncological purposes. Currently available CED devices are not approved for extended indwelling use, and the only potential at this time is for sequential treatments through multiple procedures. The authors report on the safety and experience in a group of pediatric patients who received sequential CED into the brainstem for the treatment of diffuse intrinsic pontine glioma.METHODSPatients in this study were enrolled in a phase I single-center clinical trial using 124I-8H9 monoclonal antibody (124I-omburtamab) administered by CED (clinicaltrials.gov identifier NCT01502917). A retrospective chart and imaging review were used to assess demographic data, CED infusion data, and postoperative neurological and surgical outcomes. MRI scans were analyzed using iPlan Flow software for volumetric measurements. Target and catheter coordinates as well as radial, depth, and absolute error in MRI space were calculated with the ClearPoint imaging software.RESULTSSeven patients underwent 2 or more sequential CED infusions. No patients experienced Clinical Terminology Criteria for Adverse Events grade 3 or greater deficits. One patient had a persistent grade 2 cranial nerve deficit after a second infusion. No patient experienced hemorrhage or stroke postoperatively. There was a statistically significant decrease in radial error (p = 0.005) and absolute tip error (p = 0.008) for the second infusion compared with the initial infusion. Sequential infusions did not result in significantly different distribution capacities between the first and second infusions (volume of distribution determined by the PET signal/volume of infusion ratio [mean ± SD]: 2.66 ± 0.35 vs 2.42 ± 0.75; p = 0.45).CONCLUSIONSThis series demonstrates the ability to safely perform sequential CED infusions into the pediatric brainstem. Past treatments did not negatively influence the procedural workflow, technical application of the targeting interface, or distribution capacity. This limited experience provides a foundation for using repeat CED for oncological purposes.
KULTUR POLITIK TRADISIONAL JAWA PADA MASA REZIM ORDE BARU TAHUN 1967-1998
Authors: Kasman Aloysius , Rahadian Septa 
Published: September 2020

Penelitian ini bertujuan mendeskripsikan Rezim Orde Baru yang merupakan apa yang dilakukan Orde Baru melalui kekuasannya. Dalam ilmu politik, kekuasaan digunakan untuk mencapai tujuan yang lebih besar, yakni mcenyejahterakan rakyatnya, termasuk ideologi apa yang digunakan. Orde Baru hadir sebagai antitesis dari era demokrasi parlementer dan demokrasi terpimpin membuat, jarak terhadapnya, bahkan memperlihatkan permusuhan terhadap Orde Lama. Kekuasaan Orde Baru bermula pada tahun 1967-1998.
Penelitian ini menggunakan metode sejarah yang merupakan catatan relevansi dengan pemerintahan rezim Orde Baru yang berlandaskan pada kultur politik tradisional Jawa, jauh sebelum kedatangan kolonial Belanda di Nusantara. Metode-metode sejarah yang dipaparkan seperti, Pemilihan Topik (kedekatan emosional dan kedekatan intelektual ), Heuristik ( mencari dan mengumpulkan data ), Verifikasi ( kritik sumber buku interen dan eksteren ), Interpretasi (penafsiran) dan Historiografi (catatan sejarah ). Kemudian hasil dari penelitian Kultur politik tradional Jawa yang lahir jauh sebelum masa kolonial Belanda abad ke- xix sebagai dasar efektivitas penyalahgunaan kekuasaan Rezim Orde tahun 1967 sampai 1998 di Indoesia.
Model Pewarisan Cerita Rakyat melalui Lomba Storytelling
Authors: Sofyan Nur Israfyan, 
Published: September 2020

Makalah ini bertujuan untuk memaparkan hasil pengamatan saya tentang upaya pemertahanan cerita rakyat melalui lomba strorytelling bagi siswa sekolah menengah. Lomba storytelling adalah salah satu mata lomba yang ada di gelaran English Expo dan diadakan setiap tahun oleh mahasiswa Jurusan Pendidikan Bahasa Inggris FKIP Universitas Halu Oleo. Cerita rakyat, oleh setiap siswa peserta lomba, diterjemahkan ke dalam Bahasa Inggris dan dipertunjukkan. Hasil temuan saya menunjukkan bahwa lomba storytelling menjadi ajang pewarisan cerita rakyat. Proses pewarisan cerita rakyat melalui lomba storytelling tidak saja berefek kepada tersampaikannya cerita rakyat yang mengandung konsep kebudayaan masyarakat pemilik cerita rakyat tetapi juga menjadi ajang pemahaman lintas kebudayaan bagi anak-anak seusia sekolah menengah. Lebih lanjut, mereka dapat menjadi agen budaya dalam memperkenalkan konsep kebudayaan melalui lomba storytelling.Istilah kunci: storytelling, pewarisan dan pemahaman lintas budaya.