bluuebunny/crossref_metadata_2025_split huggingface dataset:
CT pattern of Infarct location and not infarct volume determines outcome after decompressive hemicraniectomy for Malignant Middle Cerebral Artery Stroke
Authors: Kamran Saadat , Akhtar Naveed , Salam Abdul , Alboudi Ayman , Kamran Kainat , Imam Yahiya Bashir , Amir Numan , Ali Musab , Haroon Khawaja Hasan , Muhammad Ahmad , Ahmad Arsalan , Ayyad Ali , Elalamy Osama , Inshasi Jihad , Shuaib Ashfaq 
Published: November 2019

AbstractMalignant middle cerebral artery [MMCA] infarction has a different topographic distribution that might confound the relationship between lesion volume and outcome. Retrospective study to determine the multivariable relationship between computerized tomographic [CT] infarct location, volume and outcomes in decompressive hemicraniectomy [DHC] for MMCA infarction. The MCA infarctions were classified into four subgroups by CT, subtotal, complete MCA [co-MCA], Subtotal MCA with additional infarction [Subtotal MCAAI] and co-MCA with additional infarction [Co-MCAAI]. Maximum infarct volume [MIV] was measured on the pre-operative CT. Functional outcome was measured by the modified Rankin Scale [mRS] dichotomized as favourable 0–3 and unfavourable ≥4, at three months. In 137 patients, from least favourable to favourable outcome were co-MCAAI, subtotal MCAAI, co-MCA and subtotal MCA infarction. Co-MCAAI had the worst outcome, 56/57 patients with additional infarction had mRS ≥ 4. Multiple comparisons Scheffe test showed no significant difference in MIV of subtotal infarction, co-MCA, Subtotal MCAAI but the outcome was significantly different. Multivariate analysis confirmed MCAAI [7.027 (2.56–19.28), p = 0.000] as the most significant predictor of poor outcomes whereas MIV was not significant [OR, 0.99 (0.99–01.00), p = 0.594]. Other significant independent predictors were age ≥ 55 years 12.14 (2.60–56.02), p = 0.001 and uncal herniation 4.98(1.53–16.19), p = 0.007]. Our data shows the contribution of CT infarction location in determining the functional outcome after DHC. Subgroups of patients undergoing DHC had different outcomes despite comparable infarction volumes.
Prolonged international normalized ratio and vascular injury at divisional level predict embolization failures of patients with iatrogenic renal vascular injuries
Authors: Lee Shen-Yang , Wang Mei-Lin , Wong Yon-Cheong , Wu Cheng-Hsian , Wang Li-Jen 
Published: November 2019

AbstractTranscatheter arterial embolization (TAE), as an alternative to surgery for iatrogenic renal vascular injury (IRVI), may have unsatisfactory outcomes. Nonetheless, there is inadequate information regarding the predictors of TAE outcomes for IRVI in the literature. The aim of this retrospective study was to investigate the predictors of TAE outcomes for IRVI. Of 47 patients, none had major complications, 17 (36.2%) patients had minor complications, and none suffered significant renal function deterioration after TAE. Technical success and clinical success were 91.5% and 93.6%, respectively. Technical failure was associated with older age, thrombocytopenia, prolonged international normalized ratio (INR) and divisional IRVI. Clinical failure was associated with kidney failure, use of steroids, prolonged INR, and divisional IRVI. In addition, prolonged INR was a significant predictor of technical failure. This implies that aggressive measures to control the INR prior to TAE are warranted to facilitate technical success, and technical success could then be validated on post-TAE images. Furthermore, divisional IRVI was a predictor of clinical failure. Thus, divisional IRVI should undergo surgery first since TAE is prone to clinical failure. The avoidance of clinical failure is validated if divisional IRVI does not need further intervention.
Paternal activation of CB2 cannabinoid receptor impairs placental and embryonic growth via an epigenetic mechanism
Authors: Innocenzi Elisa , De Domenico Emanuela , Ciccarone Fabio , Zampieri Michele , Rossi Gabriele , Cicconi Rosella , Bernardini Roberta , Mattei Maurizio , Grimaldi Paola 
Published: November 2019

AbstractThe cannabinoid receptor type 2 (CB2) is the peripheral receptor for cannabinoids, involved in the homeostatic control of several physiological functions. Male mitotic germ cells express a high level of CB2, whose activation promotes their differentiation in both in vitro and in vivo experiments, controlling the correct progression of spermatogenesis. However, it remains elusive if CB2 activation in spermatogonia could affect reproductive success in terms of fertility and healthy pregnancy outcomes. In this study, we explored the effects of male CB2 activation on sperm number and quality and its influence on next generation health. We show that exposure of male mice to JWH-133, a selective CB2 agonist, decreased sperm count, impaired placental development and reduced offspring growth. These defects were associated with altered DNA methylation/hydroxymethylation levels at imprinted genes in sperm and conserved in placenta. Our findings reveal that paternal selective activation of CB2 alters the sperm epigenome and compromises offspring growth. This study demonstrates, for the first time, a new role of CB2 signaling in male gametes in causing epigenetic alterations that can be transmitted to the next generation by sperm, highlighting potential risks induced by recreational cannabinoid exposure.
Nicotinic acid promotes sleep through prostaglandin synthesis in mice
Authors: Szentirmai Éva , Kapás Levente 
Published: November 2019

AbstractNicotinic acid has been used for decades for its antiatherogenic properties in humans. Its actions on lipid metabolism intersect with multiple sleep regulatory mechanisms, but its effects on sleep have never been documented. For the first time, we investigated the effects of acute systemic administration of nicotinic acid on sleep in mice. Intraperitoneal and oral gavage administration of nicotinic acid elicited robust increases in non-rapid-eye movement sleep (NREMS) and decreases in body temperature, energy expenditure and food intake. Preventing hypothermia did not affect its sleep-inducing actions suggesting that altered sleep is not secondary to decreased body temperature. Systemic administration of nicotinamide, a conversion product of nicotinic acid, did not affect sleep amounts and body temperature, indicating that it is not nicotinamide that underlies these actions. Systemic administration of monomethyl fumarate, another agonist of the nicotinic acid receptor GPR109A, fully recapitulated the somnogenic and thermoregulatory effects of nicotinic acid suggesting that they are mediated by the GPR109A receptor. The cyclooxygenase inhibitor indomethacin completely abolished the effects of nicotinic acid indicating that prostaglandins play a key role in mediating the sleep and thermoregulatory responses of nicotinic acid.
Enhancing Colorectal Cancer Radiation Therapy Efficacy using Silver Nanoprisms Decorated with Graphene as Radiosensitizers
Authors: Habiba Khaled , Aziz Kathryn , Sanders Keith , Santiago Carlene Michelle , Mahadevan Lakshmi Shree Kulumani , Makarov Vladimir , Weiner Brad R. , Morell Gerardo , Krishnan Sunil 
Published: November 2019

AbstractMetal nanoparticles have significant interaction cross-sections with electromagnetic waves due to their large surface area-to-volume ratio, which can be exploited in cancer radiotherapy to locally enhance the radiation dose deposition in tumors. We developed a new type of silver nanoparticle composite, PEGylated graphene quantum dot (GQD)-decorated Silver Nanoprisms (pGAgNPs), that show excellent in vitro intracellular uptake and radiosensitization in radiation-sensitive HCT116 and relatively radiation-resistant HT29 colorectal cancer cells. Furthermore, following biodistribution analysis of intravenously injected nanoparticles in nude mice bearing HCT116 tumors radiosensitization was evaluated. Treatment with nanoparticles and a single radiation dose of 10 Gy significantly reduces the growth of colorectal tumors and increases the survival time as compared to treatment with radiation only. Our findings suggest that these novel nanoparticles offer a promising paradigm for enhancing colorectal cancer radiation therapy efficacy.
Nanoparticle induced barrier function assessment at liquid–liquid and air–liquid interface in novel human lung epithelia cell lines
Authors: Leibrock Lars , Wagener Sandra , Singh Ajay Vikram , Laux Peter , Luch Andreas 
Published: November 2019

Abstract
Inhalation is the most relevant entry point for nanoparticles (NPs) into the human body. To date, toxicity testing of nanomaterials in respect to oral, dermal and inhalative application is mainly based on animal experiments. The development of alternative test methods is the subject of current research. In vitro models can help to investigate mechanistic aspects, as e.g. cellular uptake or genotoxicity and might help to reduce in vivo testing. Lung cell lines are proper in vitro tools to assess NP toxicity. In respect to this, various cell models have been developed during the recent years, but often lack in a proper intact barrier function. However, besides other important in vivo criteria which are still missing like e.g. circulation, this is one basic prerequisite to come closer to the in vivo situation in certain mechanistic aspects such as particle translocation which is an important task for risk assessment of nanomaterials. Novel developed in vitro models may help to investigate the translocation of nanomaterials from the lung. We investigated the barrier function of the recently developed human lung cell lines CI-hAELVi and CI-huAEC. The cells were further exposed to CeO2 NPs and ZnO NPs, and their suitability as in vitro models for toxicological investigations was proven. The obtained data were compared with data generated with the A549 cell line. Measurement of transepithelial resistance and immunohistochemical examination of tight junctions confirmed the formation of a functional barrier for both cell lines for submerged and air–liquid cultivation. For particle exposure, hAELVi and huAEC cells showed comparable results to A549 cells without losing the barrier function. CeO2 NP exposure revealed no toxicity for all cell lines. In contrast, ZnO NPs was toxic for all cell lines at a concentration between 10–50 μg ml−1. Due to the comparable results to A549 cells CI-hAELVi and CI-huAEC offer new opportunities to investigate nanoparticle cell interactions more realistic than recent 2D cell models.
Looking Through the Kaleidoscope: Stakeholder Perspectives on an International Speech-Language Pathology Placement
Authors: Staley Bea , Ellwood Lynn , Rochus David , Gibson Rachael , Hong Dain , Kwan Katie 
Published: November 2019

Purpose
In this article, we consider the literature on international student placements to contextualize and describe a 10-year relationship that enables speech-language pathology (SLP) students in their final year of studies at a Canadian university to complete a 10-week clinical placement with a nongovernmental organization in Kenya.

Method
This work can be best described as a qualitative case study that includes the varied perspectives of students and colleagues (from both minority and majority worlds) involved in this partnership, which annually places Canadian SLP students in Western Kenya. Perspectives include the director of the nongovernmental organization, 1 East African speech-language pathologist responsible for hosting and supervising students, the clinical placement director in Canada, and the students themselves. The perspectives of minority world universities and their students tend to be privileged and more widely represented. This work contributes to the literature by including the views of the hosting majority world SLP partner agency.

Results
The varied perspectives reveal that the perceived advantages and difficulties of international SLP clinical placements differ for various stakeholders.

Conclusions
As the SLP profession moves forward in an increasingly globalized world, it may be necessary for SLP peak professional bodies to develop best practice frameworks for overseas engagement.
Metaphors in political communication
Authors: Heyvaert Pauline , Randour François , Dodeigne Jérémy , Perrez Julien , Reuchamps Min 
Published: November 2019

Abstract
This article analyses the use of (deliberate) metaphors in political discourse produced by French-speaking Belgian
regional parliamentarians during non-institutional political interviews. The article first investigates if the use of deliberate
metaphor limits itself to a particular type of political discourse (i.e. public and institutional political discourse) or if
metaphor use is also found in other types of settings (i.e. non-institutional political discourse). Second, the article analyses
the variation of deliberate metaphor use between political actors depending on gender, seniority and political affiliation. To
this end, the article applies Steen’s (2008) three-dimensional model of metaphor
analysis on biographical interviews conducted with French-speaking Belgian regional parliamentarians (RMPs). Our results indicate
that RMPs, when using non-deliberate metaphors, mostly rely on source domains such as construction, battle and
relationships. This is in contrast with the use of deliberate metaphors, where source domains like sports,
nature and container take the upper hand.
Generation, control, storage and retrieval of complicated shaped four-wave mixing signal
Authors: Mallick Nawaz Sarif , Dey Tarak Nath 
Published: November 2019

Abstract
We present an efficient scheme for the generation and control of a non-degenerate four-wave mixing (FWM) signal in an N-type inhomogeneously broadened 87Rb atomic system. We observe the propagation dynamics of the generated FWM signal along with the probe pulse under the condition of electromagnetically induced transparency. The FWM signal acquiring the scaled shape of the probe field travels through the medium without changing its shape and intensity. We have also shown that a time-dependent control field permits the storage and retrieval of these optical signals without losing their identity. This work allows us to generate, control, store and retrieve FWM signals of complicated shape.
Design of liquid fertilizer applicator based on Variable Rate Application (VRA) for Soybean
Authors: Fuadi M , Sutiarso L , Radi  , Virgawati S , Nugraheni P H T 
Published: November 2019

Abstract
The process of fertilization is one of the phase that is very important in improving the quality and quantity crops. The needs of plants nutrient on one stretch of the fact that not entirely uniform. In addition the use of chemical fertilizer continously with the doses increasing each year can upset the balance lands nutrient therefore it is necessary variable-rate liquid fertilizer applicator to set a dose of fertilizer required by the plant. This study attempts to design and test the performance of variable-rate liquid fertilizer applicator and soil nutrrient test. The applicator can be used to 4 line the soybean plant with distance cropping 40x20 cm. This applicator can control travel speed and dosage of fertilizers that were out of 4 Nozzle. Evaluation and its performance tested in the laboratorium. Discharge that was issued on PWM motor sprayer variations 40 to 100% produce discharge markedly dissimilar variations on each of the PWM sprayer. In application uniformity evaluations use the coefficient of variation (CV). The coefficient of variation of the discharge range 2.71-12.37% and there is a diversity of N, P and K soil contents in each land tested although the changes are not too different.
Spatial modelling of watershed health assessment by using GIS
Authors: Setyawan C , Susanto S , Lee CY 
Published: November 2019

Abstract
Watershed assessment methods have been developed in many types of approaches and purposes. However, the assessment concepts which are explicitly considering spatial aspects of a watershed remain unclear. The present study performed a spatial modeling for watershed health assessment in a Geographic Information System (GIS). Five indicators presented in GIS raster maps such as annual rainfall, land slope, land use/land cover (LULC) types, soil types and population density were used for the assessment and applied in Progo watershed, Central Java Province, Indonesia. A quantitative scoring was applied to classify indicator value and to categorize the watershed health level in five zones (very poor, poor, moderate, good and very good). The result shows that the study site is covered by three health level zones (poor, moderate and good). About 47.85% of the watershed area has a moderate health level. While, 39.04% and 13.11% of the watershed area are covered by areas with poor and good health level, respectively. Spatially, the area with poor health level is dominated by farmland and steep sloping area. Spatial modeling enables a watershed health assessment with a more specific and understandable result for watershed problems control.
Kinetics analysis of the effect of storage room temperature and packaging films characteristics on the rate of change of Sugar Palm Fruit (Arenga pinata) quality in A Modified Atmospheric Packaging (MAP)
Authors: Fatharani A , Bintoro N 
Published: November 2019

Abstract
Sugar palm fruit is a tropical fresh product which derived from sugar palm plants. Handling and storage of sugar palm fruit is still in the traditional way, and it creates difficulties for broader marketing. Storage air temperature and film packaging greatly affects to various factors of the fresh products damage that can be represented by the change in respiration rate of those produtcs. The aim of this study was to study the effect of storage temperature and plastic film characteristics on the change of the respiration rate of sugar palm fruit during storage period in the MAP. Several treatment combinations including storage temperature and plastic film thickness were investigated in the research. It was found that storage temperature had stronger effect on the respiration rate of sugar palm fruit as compared to the effect of packaging film thickness. The higher storage temperature the longer would the time to reach constant O2 and resulted in the higher respiration rate. Statistical analysis indicated that storage temperature, packaging film thickness, and the interaction of those two factors were significantly affect the respiration rate of the fruit. Arrhenius kinetics could explain the effect of storage temperature on respiration rate of sugar palm fruit.
Investigating the impact of Palm Sap Sugar proportion and fat content on heat stability of Milk Chocolate
Authors: Nafingah R , Kurniasari J , Cahyani A , Harmayani E , Saputro A D 
Published: November 2019

Abstract
Chocolate is characterised by its solid texture at relatively low temperature. However, it will easily melt as the temperature increase. This phenomenon contributes to the low level of chocolate quality in tropical countries. In order to cope with this problem, an innovation in producing thermostable chocolate is highly required. This work investigated the impact of fat content and palm sap sugar proportion on the heat stability of milk chocolate. Hardness of chocolate was used as a parameter to evaluate the chocolate stability against storage temperature. In this study, three levels of fat content, namely 30%, 32%, 34% and five palm sap sugar levels, namely 0%,25%,50%,75%,100% were used. The results showed that fat content, palm sap sugar proportion and their interaction significantly influenced the hardness of milk chocolate. Due to its moisture content, the hardness of chocolate increased as the proportion of palm sap sugar was increased. In contrast, at the same level of palm sap sugar proportion, the increase of fat content decreased the hardness of milk chocolate.
Changes of Petai during drying using freeze drying method
Authors: Akbar M A , Karyadi J N W , Imaniar D I , Mar’fuah S , Hati F I P 
Published: November 2019

Abstract
Petai (Parkia speciosa) is a plant of the type of legumes (Fabaceae). This plant is spread in Southeast Asian countries, especially in Indonesia, which is usually consumed as fresh food. Petai production increased from 2016 to 2017 by 9.45%, therefore petai is very abundant in Indonesia. Petai is known to contain sulfidic acid which is strong and easily damaged like other agricultural products. This causes a decrease in physical and chemical quality so that it can reduce consumer interest. One way to maintain the quality of agricultural products is frozen. This method is the most effective drying method. The purpose of this study was to study freeze-drying methods on the physical and chemical quality of petai seeds. The material used is petai pods that have been replaced from the skin of the aris. Petai pods are processed into dry petai. The freeze drying machine used has stainless steel with a total size of 0.7 m, width 0.5 m, and height 1 m. Drying was carried out by heating 60°C at a vacuum pressure of -73.5 cmHg. The initial air content (wet basis) produced by the thermogravimetric method with three samples averaged 83.61%, after drying the air content (wet basis) decreased by 9.868%. The study sample also showed physical changes using the color of three sample seeds. The mean values of colors L, a *, and b * before drying are 68.468; -24.123; and 35.167. After drying, the values of L, a *, and b * are 42.817; -21.76; and 18.977.
Development of mobile-based apps for oil palm fresh fruit bunch transport monitoring system
Authors: Krisdiarto A W , Wisnubhadra I 
Published: November 2019

Abstract
After being harvested, the oil palm fresh fruit bunch (FFB) has to be evacuated from the field and transported to the oil palm mill. In most cases, it transported using the trucks. FFB transportation should be optimized in order to achieve the best FFB quality and minimum cost. This research was aimed to develop tools to monitor trucks as FFB transport equipment, due to some deviations in the field. The Development of the application using these method: business process analysis, system analysis, system design, and implementation and functional test. The application software run as an Android-based application, as a map-based application, and using location-based service. The system also runs as a web-based application and has been tested on FFB logistic system in private plantation company. It monitored the truck route and FFB loading and transporting activities in the field, as well as gave instruction to the truck driver in order to avoid the heavy queue in an oil palm mill.