bluuebunny/crossref_metadata_2025_split huggingface dataset:
A espera manca e a biblioteca aberta: Samuel Beckett e Carpeaux
Authors: Andrade Fábio De Souza 
Published: July 2020

Quando da publicação da primeira edição de sua História da literatura ocidental (1959), redigida em meados dos anos 1940, Carpeaux reviu o texto original da obra para considerar a figura de Samuel Beckett, autor central no século XX, cuja peça mais conhecida, Esperando Godot, acabara de estrear. Anos depois, em 1976, o crítico tornou a se ocupar do dramaturgo irlandês, publicando uma análise de Godot na revista Manchete. Como esse encontro em dois tempos, entre o crítico/historiador e o romancista/dramaturgo, pode revelar aspectos da natureza de seus projetos autorais e dos contextos diversos, mas comunicantes, que os mobilizam?
Teatro e abolição: A cabana do pai Tomás nos palcos brasileiros
Authors: Faria João Roberto 
Published: July 2020

O romance A cabana do pai Tomás, de Harriet Beecher Stowe, teve um grande papel para o fortalecimento de uma consciência antiescravista em nível internacional. Publicado em livro em 1852, tornou-se um dos maiores best-sellers do século XIX. Neste artigo, demonstra-se a importância das adaptações que chegaram aos palcos brasileiros para a luta abolicionista do país.
Exegetical Puzzles and the Mystical Theologies of Gregory of Nyssa and Dionysius the Areopagite
Authors: Conway-Jones Ann 
Published: July 2020

Abstract
Gregory of Nyssa and Dionysius the Areopagite both contemplate the Exodus narrative of Moses’ experiences on Sinai. That narrative is complex, with Moses ascending and descending the mountain several times, sometimes in company, sometimes alone. Gregory follows the biblical twists and turns in Life of Moses; the relevant paragraph in Dionysius’ Mystical Theology tells of just one ascent. This article re-examines their dependence on the details of the biblical text, arguing that its exegetical puzzles proved fertile ground for their apophatic insights. Both seize on Exodus 20:21 as symbolising the utter incomprehensibility of God. But they resolve the enigmas of Exodus 33–34 differently. Gregory uses Exodus 33:18–23 as a springboard to his articulation of a never-ending journey into the infinite divine, while Exodus 34:29–35 provides the biblical impetus behind Dionysius’ concept of “union.”
Aviation Impacts on Fuel Efficiency of a Future More Viscous Atmosphere
Authors: Ren Diandong , Fu Rong , Dickinson Robert E. , Leslie Lance M. , Wang Xingbao 
Published: July 2020

AbstractAircraft cruising near the tropopause currently benefit from the highest thermal efficiency and the least viscous (sticky) air, within the lowest 50 km of Earth’s atmosphere. Both advantages wane in a warming climate, because atmospheric dynamic viscosity increases with temperature, in synergy with the simultaneous engine efficiency reduction. Here, skin friction drag, the dominant term for extra aviation fuel consumption in a future warming climate, is quantified by 34 climate models under a strong emissions scenario. Since 1950, the viscosity increase at cruising altitudes (∼200 hPa) reaches ∼1.5% century‒1, corresponding to a total drag increment of ∼0.22% century‒1 for commercial aircraft. Meridional gradients and regional disparities exist, with low to midlatitudes experiencing greater increases in skin friction drag. The North Atlantic corridor (NAC) is moderately affected, but its high traffic volume generates additional fuel cost of ∼3.8 × 107 gallons annually by 2100, compared to 2010. Globally, a normal year after 2100 would consume an extra ∼4 × 106 barrels per year. Intermodel spread is <5% of the ensemble mean, due to high inter–climate model consensus for warming trends at cruising altitudes in the tropics and subtropics. Because temperature is a well-simulated parameter in the IPCC archive, with only a moderate intermodel spread, the conclusions drawn here are statistically robust. Notably, additional fuel costs are likely from the increased vertical shear and related turbulence at NAC cruising altitudes. Increased flight log availability is required to confirm this apparent increasing turbulence trend.
Lay Detection of Unusual Patterns in the Frequency of Hurricanes
Authors: Dryden Rachel , Morgan M. Granger , Broomell Stephen 
Published: July 2020

AbstractAn increase in the severity of extreme weather is arguably one of the most important consequences of climate change with immediate and potentially devastating impacts. Recent events, like Hurricane Harvey, stimulated public discourse surrounding the role of climate change in amplifying, or otherwise modifying, the patterns of such events. Within the scientific community, recent years have witnessed considerable progress on “climate attribution”—the use of statistical techniques to assess the probability that climate change is influencing the character of some extreme weather events. Using a novel application of signal detection theory, this article assesses when, and to what extent, laypeople attribute changes in hurricanes to climate change and whether and how certain characteristics predict this decision. The results show that people attribute hurricanes to climate change based on their preexisting climate beliefs and numeracy. Respondents who were more dubious about the existence of climate change (and more numerate) required a greater degree of evidence (i.e., a more extreme world) before they were willing to suggest that an unusual hurricane season might be influenced by climate change. However, those who have doubts were still willing to make these attributions when hurricane behavior becomes sufficiently extreme. In general, members of the public who hold different prior views about climate change are not in complete disagreement about the evidence they perceive, which leaves the possibility for future work to explore ways to bring such judgments back into alignment.
Systematic Review of Negative Pressure Pulmonary Edema in Otolaryngology Procedures
Authors: Din-Lovinescu Corina , Trivedi Usha , Zhang Kathy , Barinsky Gregory L. , Grube Jordon G. , Eloy Jean Anderson , Hsueh Wayne D. 
Published: July 2020

Objective(s): Negative pressure pulmonary edema (NPPE) is a rare perioperative complication with a potentially fatal outcome. The aim of this study was to perform a systematic review of NPPE in adult otolaryngology procedures with the goal of identifying risk factors, clinical presentation, diagnosis, management and outcomes. Methods: Systematic review performed using PubMed, Scopus, Web of Science, and Cochrane databases. Results: Sixty-nine studies including data from 87 individual patients were included in this review. Fifty-six (68%) patients were male and the average patient age was 37 years old. Type 1 NPPE occurred in 63 (72%) cases, while type 2 NPPE accounted for 20 (23%) cases. The most common procedures leading to NPPE were septoplasty, rhinoplasty or sinus surgery (n = 22, 25%), directly laryngoscopy or bronchoscopy (n = 13, 15%), and tracheostomy or cricothyroidotomy (n = 11, 13%). The most employed treatment options included diuretics (n = 55, 63%) and mechanical ventilation (n = 54, 62%). Seventy-eight (90%) patients made a full recovery with an average time to NPPE resolution of 33 hours and an average length of hospitalization of 5.6 days. Five (6%) patients had a long-term morbidity and four (5%) patients died, with age and ICU stay increasing risk for death and long-term morbidity (OR 1.044 and 7.42, respectively, P < .05). Conclusion: Septoplasty, rhinoplasty and sinus surgery account for the majority of NPPE cases in adult otolaryngology procedures. Young, healthy patients are the most commonly involved with a slight male predominance. The vast majority of patients recover fully, however there is a significant risk for morbidity and mortality.
Comparison of Open and Endoscopic Approaches in the Resection of Esthesioneuroblastoma
Authors: Barinsky Gregory L. , Azmy Monica C. , Kilic Suat , Grube Jordon G. , Baredes Soly , Hsueh Wayne D. , Eloy Jean Anderson 
Published: July 2020

Background: Olfactory neuroblastoma, or esthesioneuroblastoma (ENB), is an uncommon sinonasal malignancy arising from olfactory neuroepithelium that is optimally treated with surgical resection. The objective of this study is to determine preoperative predictors of undergoing open versus endoscopic approach for ENB and to investigate significant postoperative survival outcomes between the two surgical approaches. Methods: The National Cancer Database (NCDB) was queried for cases of ENB histology that were treated surgically from 2010 to 2015. Groups were stratified into open or endoscopic approach cohorts. Patient demographics, tumor characteristics, treatment modality, and 5-year overall survival were compared between the two groups using Chi-Square analysis and Kaplan-Meier survival analysis. Cases were classified as Kadish stage A, B, C, or D based on the “Collaborative Stage-Extension” codes in NCDB. Results: Of 533 patients meeting inclusion criteria, 276 (51.8%) patients underwent open, and 257 (48.2%) patients underwent endoscopic surgical approaches. Patients undergoing endoscopic surgery were more likely to be Kadish stages A and B and less likely to be stages C and D ( P = .020). Those undergoing endoscopic approach overall had a shorter mean hospital stay postoperatively (3.8 vs. 7.0 days, P < .001). Endoscopic cases had a greater 5-year overall survival (81.9% vs. 75.6%, P = .030); after multivariate regression, there was a trend toward survival benefit to endoscopic surgery that did not reach clinical significance (HR 0.644, [0.392-1.058], P = .083). Conclusion: Although not statistically significant, there is a trend toward increased overall survival with an endoscopic approach in patients undergoing surgery for ENB as compared to an open approach, regardless of Kadish stage. An endoscopic approach is an adequate alternative to an open approach for the surgical treatment of ENB.
Risk factors for agitation and hyperactive delirium in adult postcardiotomy patients with extracorporeal membrane oxygenation support: an observational study
Authors: Wang Hong , Hou Dengbang , Tian Xiaqiu , Wang Liangshan , Li Chenglong , Jia Ming , Hou Xiaotong 
Published: July 2020

Background: Agitation and delirium in critically ill patients after cardiac surgery carry poor in-hospital prognosis. Identifying risk factors may promote its prevention and management. Accordingly, this study aimed to evaluate the incidence of agitation and hyperactive delirium in postcardiotomy patients during the extracorporeal membrane oxygenation support and to identify the risk factors for its development. Methods: This single center, retrospective study was conducted at Beijing Anzhen Hospital, Capital Medical University. Data were extracted from the prospective institutional registry database of extracorporeal membrane oxygenation patients. Univariate and multivariate logistic regression analyses were performed to predict risk factors. Results: A total of 170 consecutive adult patients underwent extracorporeal membrane oxygenation in our hospital from January 2016 to December 2017. Ninety-four patients were included in the final analysis. The incidence of agitation and hyperactive delirium was 35% in our population of extracorporeal membrane oxygenation–supported postcardiotomy patients. Agitation and delirium usually occurred within the first 3 days of extracorporeal membrane oxygenation. Multivariable analysis showed that history of previous stroke (without preoperative cognitive dysfunction; odds ratio, 4.425, 95% confidence interval: 1.171-16.716; p = 0.028) and mean arterial pressure reduction (before extracorporeal membrane oxygenation initiation) ⩾ 49 mmHg (odds ratio, 7.570, 95% confidence interval: 2.366-24.219, p = 0.001) were independent risk factors for agitation and hyperactive delirium during extracorporeal membrane oxygenation support. The areas under the receiver operating characteristic curve for the prediction of agitation and hyperactive delirium was 0.704 (95% confidence interval 0.589-0.820, p = 0.001). There was more severe arrhythmia in the agitation patients. Conclusion: Our results suggest that the prevalence of agitation and hyperactive delirium in postcardiotomy patients with extracorporeal membrane oxygenation support is high. In addition, previous stroke and severe mean arterial pressure reduction before extracorporeal membrane oxygenation initiation is predictive of agitation and hyperactive delirium.
Tendon Regeneration After Partial-Thickness Peroneus Longus Tendon Harvesting: Magnetic Resonance Imaging Evaluation and In Vivo Animal Study
Authors: Lee Ho Won , Wang Chenyu , Bae Tae Soo , Yang Ik , Liu Yuxuan , Park Chang Won , Kim Hyong Nyun 
Published: July 2020

Background: In recent years, the use of the anterior half of the peroneus longus tendon (AHPLT) as an autograft source for ligament reconstruction has gained popularity. However, no reports are available regarding tendon regeneration after harvesting of the AHPLT. Hypothesis: When half of the tendon is preserved during tendon harvesting, the quality of the regenerated tendon is better than that of the regenerated tendon after full-thickness harvesting. Study Design: Case series; Level of evidence, 4; controlled laboratory study. Methods: A total of 21 patients who underwent AHPLT harvesting for lower extremity ligament reconstruction participated in the magnetic resonance imaging (MRI) study to evaluate tendon regeneration 1 year after the harvesting. An in vivo animal study was performed to compare the quality of the regenerated tendon after partial-thickness and full-thickness tendon harvesting. A total of 30 adult female Sprague-Dawley rats were allocated to 2 groups—15 rats underwent partial-thickness Achilles tendon harvesting (partial-thickness harvesting [PTH] group), and 15 rats underwent full-thickness Achilles tendon harvesting (full-thickness harvesting [FTH] group). The quality of the regenerated tendons was compared 180 days after tendon harvesting. Results: All 21 patients showed regeneration of the peroneus longus tendon (PLT) (homogeneously dark on both T1- and T2-weighted sequences). The cross-sectional area of the regenerated tendon divided by that of the preoperative tendon was 92.6% and 84.5% at 4 cm and 9 cm proximal to the tip of the distal fibula, respectively. In the animal study, the mean histologic score was better for the PTH group compared with the FTH group (9.17 ± 1.35 vs 14.72 ± 0.74; P < .001). The ultimate strength and the stiffness of the regenerated Achilles tendon were significantly higher for the PTH group compared with the FTH group (35.5 ± 8.3 vs 22.4 ± 8.3 N, P = .004; and 31.6 ± 7.7 vs 23.5 ± 4.8 N/mm, P = .016). Conclusion: The PLT was found to regenerate after partial-thickness harvesting on MRI. In the animal study, the quality of the regenerated tendon when half of the tendon was preserved during tendon harvesting was better than that after full-thickness tendon harvesting.
Association of interleukin-6 gene polymorphisms and glaucoma: Systematic review and meta-analysis
Authors: Wu Chien-Liang , Yang Ya-Ting , Wang Yuan-Hung , Lin Tzu-Yu , Lin I-Chan , Sung Chih-Wei 
Published: July 2020

Aim: To conduct a systematic review and meta-analysis to explore the association between IL-6 gene polymorphisms ( rs1800795 and rs1524107) and glaucoma. Methods: A comprehensive search was performed to select eligible studies regarding IL-6 polymorphisms and glaucoma. The effect sizes in the fixed-effects model were calculated using odds ratios (ORs) with 95% confidence intervals (CIs). Results: Four eligible studies comprising 762 cases and 799 controls were selected for meta-analysis. Regarding the association between the IL-6 rs1800795 polymorphism and glaucoma, those who carried the G/G+G/C genotypes had a non-significant higher risk of glaucoma (OR = 1.29, 95% CI = 0.76–2.19) in the dominant model. However, no obvious association (OR = 0.97, 95% CI = 0.68–1.37) was found for the recessive model (G/G vs G/C+C/C). In the subgroup analysis stratified by ethnicity, no significant associations were observed in populations of Asian or European heritage. Significantly higher glaucoma risks of 15.9 and 99.0 were observed for the dominant (C/C+C/T vs T/T) and recessive (C/C vs C/T+T/T) models, respectively. Conclusion: No statistically significant glaucoma risks were observed for the rs1800795 except rs1524107 polymorphism of IL-6. Further studies with a larger sample size are required to validate the effects of IL-6 polymorphisms on glaucoma risk.
Generalizing rate heterogeneity across sites in statistical phylogenetics
Authors: Heaps Sarah E , Nye Tom MW , Boys Richard J , Williams Tom A , Cherlin Svetlana , Embley T Martin 
Published: July 2020

Phylogenetics uses alignments of molecular sequence data to learn about evolutionary trees relating species. Along branches, sequence evolution is modelled using a continuous-time Markov process characterized by an instantaneous rate matrix. Early models assumed the same rate matrix governed substitutions at all sites of the alignment, ignoring variation in evolutionary pressures. Substantial improvements in phylogenetic inference and model fit were achieved by augmenting these models with multiplicative random effects that describe the result of variation in selective constraints and allow sites to evolve at different rates which linearly scale a baseline rate matrix. Motivated by this pioneering work, we consider an extension using a quadratic, rather than linear, transformation. The resulting models allow for variation in the selective coefficients of different types of point mutation at a site in addition to variation in selective constraints. We derive properties of the extended models. For certain non-stationary processes, the extension gives a model that allows variation in sequence composition, both across sites and taxa. We adopt a Bayesian approach, describe an MCMC algorithm for posterior inference and provide software. Our quadratic models are applied to alignments spanning the tree of life and compared with site-homogeneous and linear models.
Risk factors associated with 30-day hospital readmission after carotid endarterectomy
Authors: Braet Drew J , Smith Jamie B , Bath Jonathan , Kruse Robin L , Vogel Todd R 
Published: July 2020

Objective The current study evaluated all-cause 30-day readmissions after carotid endarterectomy. Methods Patients undergoing carotid endarterectomy were selected from the Cerner Health Facts® database using ICD-9-CM procedure codes from their index admission. Readmission within 30 days of discharge was determined. Chi-square analysis determined characteristics of the index admission (demographics, diagnoses, postoperative medications, and laboratory results) associated with readmission. Multivariate logistic regression models were used to identify characteristics independently associated with readmission. Results In total, 5257 patients undergoing elective carotid endarterectomy were identified. Readmission within 30 days was 3.1%. After multivariable adjustment, readmission was associated with end-stage renal disease (OR: 3.21, 95% CI: 1.01–10.2), hemorrhage or hematoma (OR: 2.34, 95% CI: 1.15–4.77), procedural complications (OR: 3.07, 95% CI: 1.24–7.57), use of bronchodilators (OR: 1.48, 95% CI: 1.03–2.11), increased Charlson index scores (OR: 1.22, 95% CI: 1.08–1.38), and electrolyte abnormalities (hyponatremia < 135 mEq/L (OR: 1.69, 95% CI: 1.07–2.67) and hypokalemia less than 3.7 mEq/L (OR: 2.26, 95% CI: 1.03–4.98)). Conclusions Factors associated with readmission following carotid endarterectomy included younger age, increased comorbidity burden, end-stage renal disease, electrolyte disorders, the use of bronchodilators, and complications including bleeding (hemorrhage or hematoma). Of note, in this real-world study, only 40% of the patients received protamine, despite evidence-based literature demonstrating the reduced risk of bleeding complications. As healthcare moves towards quality of care-driven reimbursement, physician modifiable targets such as protamine utilization to reduce bleeding are greatly needed to reduce readmission, and failure to reduce preventable physician-driven complications after carotid interventions may be associated with decreased reimbursement.
Humeral shaft fractures: how effective really is functional bracing?
Authors: Kocialkowski Cezary , Sheridan Barnaby 
Published: July 2020

Background The aim of this study was to assess the effectiveness of functional bracing in the treatment of humeral shaft fractures and identify factors that increased the risk of delayed or non-union. Methods All patients with humeral shaft fractures treated at Musgrove Park Hospital between 2010 and 2017 were identified. Patient electronic records were reviewed to identify demographic data, as well as outcomes and complications following treatment. Radiographs were reviewed to identify fracture pattern and location as well as fracture displacement and angulation. Results In total, 65 patients were treated with functional bracing of which 22 patients (34%) had a delayed or non-union. Fracture displacement and angulation were significantly associated with delayed or non-union. In particular, patients with fractures displaced more than 30 mm or angulated more than 30° had a significantly higher risk of delayed or non-union. Fracture location or pattern was not significantly associated with delayed or non-union. Conclusion Functional bracing is an effective treatment modality for the majority of patients with humeral shaft fractures, but patients with markedly displaced or angulated fractures are at a higher risk of failure of conservative treatment and therefore early operative intervention should be considered.
Evaluation of a Novel Noninvasive Blood Glucose Monitor Based on Mid-Infrared Quantum Cascade Laser Technology and Photothermal Detection
Authors: Lubinski Thorsten , Plotka Bartosz , Janik Sergius , Canini Luca , Mäntele Werner 
Published: July 2020

Background: A prototype of a noninvasive glucometer combining skin excitation by a mid-infrared quantum cascade laser with photothermal detection was evaluated in glucose correlation tests including 100 volunteers (41 people with diabetes and 59 healthy people). Methods: Invasive reference measurements using a clinical glucometer and noninvasive measurements at a finger of the volunteer were simultaneously recorded in five-minute intervals starting from fasting glucose values for healthy subjects (low glucose values for diabetes patients) over a two-hour period. A glucose range from >50 to <350 mg/dL was covered. Machine learning algorithms were used to predict glucose values from the photothermal spectra. Data were analyzed for the average percent disagreement of the noninvasive measurements with the clinical reference measurement and visualized in consensus error grids. Results: 98.8% (full data set) and 99.1% (improved algorithm) of glucose results were within Zones A and B of the grid, indicating the highest accuracy level. Less than 1% of the data were in Zone C, and none in Zone D or E. The mean and median percent differences between the invasive as a reference and the noninvasive method were 12.1% and 6.5%, respectively, for the full data set, and 11.3% and 6.4% with the improved algorithm. Conclusions: Our results demonstrate that noninvasive blood glucose analysis combining mid-infrared spectroscopy and photothermal detection is feasible and comparable in accuracy with minimally invasive glucometers and finger pricking devices which use test strips. As a next step, a handheld version of the present device for diabetes patients is being developed.