bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the General Construction of Tightly Secure Identity-Based Signature Schemes
Authors: Wu Ge , Zhao Zhen , Guo Fuchun , Susilo Willy , Zhang Futai 
Published: January 2020

AbstractA tightly secure scheme has a reduction, where the reduction loss is a small constant. Identity-based signature (IBS) is an important cryptographic primitive, and tightly secure IBS schemes enjoy the advantage that the security parameter can be optimal to achieve a certain security level. General constructions of IBS schemes (Bellare, M., Namprempre, C., and Neven, G. (2004) Security Proofs for Identity-Based Identification and Signature Schemes. In Proc. EUROCRYPT 2004, May 2–6, pp. 268–286. Springer, Berlin, Interlaken, Switzerland; Galindo, D., Herranz, J., and Kiltz, E. (2006) On the Generic Construction of Identity-Based Signatures With Additional Properties. In Proceedings of ASIACRYPT 2006, December 3–7, pp. 178–193. Springer, Berlin, Shanghai, China) and their security have been extensively studied. However, the security is not tight and how to generally construct a tightly secure IBS scheme remains unknown. In this paper, we concentrate on the general constructions of IBS schemes. We first take an insight into previous constructions and analyze the reason why it cannot achieve tight security. To further study possible tightly secure constructions, we propose another general construction, which could be seen as a different framework of IBS schemes. Our construction requires two traditional signature schemes, whereas the construction by Bellare et al. uses one scheme in a two-round iteration. There are no additional operations in our general construction. Its main advantage is providing the possibility of achieving tight security for IBS schemes in the random oracle model. Combining two known signature schemes, we present an efficient IBS scheme with tight security as an example.
A combined RNA-seq and whole genome sequencing approach for identification of non-coding pathogenic variants in single families
Authors: Bronstein Revital , Capowski Elizabeth E , Mehrotra Sudeep , Jansen Alex D , Navarro-Gomez Daniel , Maher Mathew , Place Emily , Sangermano Riccardo , Bujakowska Kinga M , Gamm David M , Pierce Eric A 
Published: January 2020

AbstractInherited retinal degenerations (IRDs) are at the focus of current genetic therapeutic advancements. For a genetic treatment such as gene therapy to be successful, an accurate genetic diagnostic is required. Genetic diagnostics relies on the assessment of the probability that a given DNA variant is pathogenic. Non-coding variants present a unique challenge for such assessments as compared to coding variants. For one, non-coding variants are present at much higher number in the genome than coding variants. In addition, our understanding of the rules that govern the non-coding regions of the genome is less complete than our understanding of the coding regions. Methods that allow for both the identification of candidate non-coding pathogenic variants and their functional validation may help overcome these caveats allowing for a greater number of patients to benefit from advancements in genetic therapeutics. We present here an unbiased approach combining whole genome sequencing (WGS) with patient-induced pluripotent stem cell (iPSC)-derived retinal organoids (ROs) transcriptome analysis. With this approach, we identified and functionally validated a novel pathogenic non-coding variant in a small family with a previously unresolved genetic diagnosis.
Civil society perspectives on sexual violence in conflict: patriarchy and war strategy in Colombia
Authors: Kreft Anne-Kathrin 
Published: January 2020

Abstract
In international policy circles, conflict-related sexual violence (CRSV) is commonly viewed as a weapon of war, a framing that researchers have criticized as overly simplistic. Feminist scholars in particular caution that the ‘weapon of war’ framing decontextualizes sexual violence in conflict from the structural factors of gender inequality that underpin its perpetration. In light of these tensions, how do politically relevant local actors perceive the nature and the origins of conflict-related sexual violence? Civil society organizations often actively confront conflict-related sexual violence on the ground. A better understanding of how their perceptions of this violence align or clash with the globally dominant ‘weapon of war’ narratives therefore has important policy implications. Interviews with representatives of Colombian women's organizations and victims' associations reveal that these civil society activists predominantly view conflict-related sexual violence as the result of patriarchal structures. The mobilized women perceive sexual violence as a very gendered violence that exists on a continuum extending through peace, the everyday and war, and which the presence of arms exacerbates. Strategic sexual violence, too, is understood to ultimately have its basis in patriarchal structures. The findings expose a disconnect between the globally dominant ‘weapon of war’ understanding that is decontextualized from structural factors and a local approach to CRSV that establishes clear linkages to societal gender inequality.
Dairy, soy, and risk of breast cancer: those confounded milks
Authors: Fraser Gary E , Jaceldo-Siegl Karen , Orlich Michael , Mashchak Andrew , Sirirat Rawiwan , Knutsen Synnove 
Published: January 2020

AbstractBackgroundAssociations between soy, dairy intakes and breast cancer risk are inconsistent. No studies exist with large numbers of dairy consumers and soy consumers to assess mutual confounding.MethodsThe study cohort contains 52 795 North American women, initially free of cancer, followed for 7.9 years (29.7% were Black). Dietary intakes were estimated from food frequency questionnaires and, for 1011 calibration study subjects, from six structured 24-h dietary recalls. Incident invasive breast cancers were detected mainly by matching with cancer registries. Analyses used multivariable proportional hazards regression.ResultsThe participants (mean age of 57.1 years) experienced 1057 new breast cancer cases during follow-up. No clear associations were found between soy products and breast cancer, independently of dairy. However, higher intakes of dairy calories and dairy milk were associated with hazard ratios (HRs) of 1.22 [95% confidence interval (CI): 1.05–1.40] and 1.50 (95% CI 1.22–1.84), respectively, comparing 90th to 10th percentiles of intakes. Full fat and reduced fat milks produced similar results. No important associations were noted with cheese and yogurt. Substituting median intakes of dairy milk users by those of soy milk consumers was associated with HR of 0.68 (95% CI: 0.55–0.85). Similar-sized associations were found among pre- and post-menopausal cases, with CIs also excluding the null in estrogen receptor (ER+, ER-), and progesterone receptor (PR+) cancers. Less biased calibrated measurement-error adjusted regressions demonstrated yet stronger, but less precise, HRs and CIs that still excluded the null.ConclusionsHigher intakes of dairy milk were associated with greater risk of breast cancer, when adjusted for soy intake. Current guidelines for dairy milk consumption could be viewed with some caution.
Male origin microchimerism and ovarian cancer
Authors: Hallum Sara , Jakobsen Marianne Antonius , Gerds Thomas Alexander , Pinborg Anja , Tjønneland Anne , Kamper-Jørgensen Mads 
Published: January 2020

Abstract

Background
Reduced risk of ovarian cancer is commonly ascribed to reduced exposure to endogenous hormones during pregnancy, using oral contraceptives or not using hormone replacement therapy. However, exposure to hormones alone account for less than half of all cases. Many women carry small amounts of male cells—known as male origin microchimerism—in their circulation and remarkable impacts of these cells on women’s health are being published. Here, we pursue the possibility that male origin microchimerism has a role in reducing ovarian cancer risk.

Methods
We conducted a prospective case-cohort study using blood samples and questionnaire data from 700 women participating in the Danish Diet, Cancer, and Health cohort. Blood samples were analysed for Y chromosome presence as a marker of male microchimerism. We evaluated the association between male microchimerism and ovarian cancer, using weighted Cox regression models reporting hazard ratios (HRs) and corresponding 95% confidence intervals (CIs).

Results
Male microchimerism was detected in 46% of cases and 65.9% of controls. Women testing positive for male microchimerism had a reduced hazard rate of ovarian cancer compared with women testing negative (HR = 0.44, 95% CI: 0.29-0.68). We found no evidence of interaction with measures of hormonal exposures (P = 0.50).

Conclusions
For the first time we report that women who test positive for male microchimerism in their circulation have reduced rates of ovarian cancer compared with women who test negative. Although the underlying mechanisms are presently unknown, we believe male microchimerism is potent in preventing ovarian cancer.
Traps and Attractants for Monitoring Navel Orangeworm (Lepidoptera: Pyralidae) in the Presence of Mating Disruption
Authors: Burks Charles S , Higbee Bradley S , Beck John J 
Published: January 2020

Abstract
The use of aerosol mating disruption for management of the navel orangeworm Amyelois transitella (Walker) in California tree nuts has increased markedly. This treatment suppresses pheromone monitoring traps in neighboring orchards as well as in the orchard under treatment. The current study, therefore, addresses the interrelated topics of which attractant is most effective, how the number of adults captured is affected by trap design, and what sex is captured. Under most circumstances, wing traps baited with phenyl propionate (PPO) captured more adults than those baited with a 5-compound kairomone blend. Adding a pheromone lure along with the dispenser for the experimental attractant increased the number of adults captured with PPO both in and near-mating disruption. In contrast, addition of a pheromone lure along with the kairomone blend only increased the number of adults captured in orchards near but not under mating disruption. Delta traps, which are preferred by the industry, captured fewer adults than wing traps. Improvements in the number of adults captured with PPO in delta traps from addition of a pheromone lure and from design modifications were additive. Both sexes were captured by all attractants and trap designs tested, and the sex ratio was highly variable. Open traps like the wing trap captured a slightly higher proportion of males than closed traps. These findings are discussed in the context of management of the navel orangeworm.
Harnessing symbiotic plant–fungus interactions to unleash hidden forces from extreme plant ecosystems
Authors: Pérez-Alonso Marta-Marina , Guerrero-Galán Carmen , Scholz Sandra S , Kiba Takatoshi , Sakakibara Hitoshi , Ludwig-Müller Jutta , Krapp Anne , Oelmüller Ralf , Vicente-Carbajosa Jesús , Pollmann Stephan 
Published: January 2020

Abstract
Global climate change is arguably one of the biggest threats of modern times and has already led to a wide range of impacts on the environment, economy, and society. Owing to past emissions and climate system inertia, global climate change is predicted to continue for decades even if anthropogenic greenhouse gas emissions were to stop immediately. In many regions, such as central Europe and the Mediterranean region, the temperature is likely to rise by 2–5 °C and annual precipitation is predicted to decrease. Expected heat and drought periods followed by floods, and unpredictable growing seasons, are predicted to have detrimental effects on agricultural production systems, causing immense economic losses and food supply problems. To mitigate the risks of climate change, agricultural innovations counteracting these effects need to be embraced and accelerated. To achieve maximum improvement, the required agricultural innovations should not focus only on crops but rather pursue a holistic approach including the entire ecosystem. Over millions of years, plants have evolved in close association with other organisms, particularly soil microbes that have shaped their evolution and contemporary ecology. Many studies have already highlighted beneficial interactions among plants and the communities of microorganisms with which they coexist. Questions arising from these discoveries are whether it will be possible to decipher a common molecular pattern and the underlying biochemical framework of interspecies communication, and whether such knowledge can be used to improve agricultural performance under environmental stress conditions. In this review, we summarize the current knowledge of plant interactions with fungal endosymbionts found in extreme ecosystems. Special attention will be paid to the interaction of plants with the symbiotic root-colonizing endophytic fungus Serendipita indica, which has been developed as a model system for beneficial plant–fungus interactions.
The transition clinic in chronic kidney disease care
Authors: Evans Marie , Lopau Kai 
Published: January 2020

Abstract
People with advanced chronic kidney disease and evidence of progression have a high risk of renal replacement therapy. Specialized transition clinics could offer a better option for preparing these patients for dialysis, transplantation or conservative care. This review focuses on the different aspects of such transition clinics. We discuss which patients should be referred to these units and when referral should take place. Patient involvement in the decision-making process is important and requires unbiased patient education. There are many themes, both patient-centred and within the healthcare structure, that will influence the process of shared decision-making and the modality choice. Aspects of placing an access for haemodialysis and peritoneal dialysis are reviewed. Finally, we discuss the importance of pre-emptive transplantation and a planned dialysis start, all with a focus on multidisciplinary collaboration at the transition clinic.
Subtype switching in breast cancer brain metastases: a multicenter analysis
Authors: Hulsbergen Alexander F C , Claes An , Kavouridis Vasileios K , Ansaripour Ali , Nogarede Claudine , Hughes Melissa E , Smith Timothy R , Brastianos Priscilla K , Verhoeff Joost J C , Lin Nancy U , Broekman Marike L D 
Published: January 2020

AbstractBackgroundBreast cancer (BC) brain metastases (BM) can have discordant hormonal or human epidermal growth factor receptor 2 (HER2) expression compared with corresponding primary tumors. This study aimed to describe incidence, predictors, and survival outcomes of discordant receptors and associated subtype switching in BM.MethodsBCBM patients seen at 4 tertiary institutions who had undergone BM resection or biopsy were included. Surgical pathology reports were retrospectively assessed to determine discordance between the primary tumor and the BCBM. In discordant cases, expression in extracranial metastases was also assessed.ResultsIn BM from 219 patients, prevalence of any discordance was 36.3%; receptor-specific discordance was 16.7% for estrogen, 25.2% for progesterone, and 10.4% for HER2. Because estrogen and progesterone were considered together for hormonal status, 50 (22.8%) patients switched subtype as a result; 20 of these switches were HER2 based. Baseline subtype predicted switching, which occurred in up to 37.5% of primary HR+ patients. Moreover, 14.8% of initially HER2-negative patients gained HER2 in the BM. Most (63.6%) discordant patients with extracranial metastases also had discordance between BM and extracranial subtype. Loss of receptor expression was generally associated with worse survival, which appeared to be driven by estrogen loss (hazard ratio = 1.80, P = 0.03). Patients gaining HER2 status (n = 8) showed a nonsignificant tendency toward improved survival (hazard ratio = 0.64, P = 0.17).ConclusionsIn this multicenter study, we report incidence and predictors of subtype switching, the risk of which varies considerably by baseline subtype. Switches can have clinical implications for prognosis and treatment choice.
Four-Dimensional Magnetic Resonance Imaging Assessment of Intracranial Aneurysms: A State-of-the-Art Review
Authors: Castle-Kirszbaum Mendel , Maingard Julian , Lim Ruth P , Barras Christen D , Kok Hong Kuan , Chandra Ronil V , Chong Winston , Asadi Hamed 
Published: January 2020

Abstract
Treatment of unruptured intracranial aneurysms can reduce the risk of subarachnoid hemorrhage and its associated morbidity and mortality. However, current methods to predict the risk of rupture and optimize treatment strategies for intracranial aneurysms are limited. Assessment of intra-aneurysmal flow using 4-dimensional magnetic resonance imaging (4D MRI) is a novel tool that could be used to guide therapy. A systematic search of the literature was performed to provide a state-of-the-art review on 4D MRI assessment of unruptured intracranial aneurysms. A total of 18 studies were available for review. Eccentric flow on 4D MRI is associated with a greater aspect ratio and peak wall shear stress (WSS). WSS, vorticity, and peak velocity are greater in saccular than fusiform aneurysms. Unstable aneurysms are associated with greater WSS, peak wall stress, and flow jet angle and may exhibit wall enhancement. In comparison to computational fluid dynamics (CFD), 4D MRI has a lower spatial resolution and reports lower WSS and velocity magnitudes, but these parameters equalize when spatial resolution is matched. 4D MRI demonstrates the intra-aneurysmal hemodynamic changes associated with flow diversion, including significantly decreased flow velocity. Thus, 4D MRI is a novel, noninvasive imaging tool used for the evaluation of hemodynamics within intracranial aneurysms. Hemodynamic indices derived from 4D MRI appear to correlate well with the simulated (CFD) values and may be used to measure the success of endovascular therapies and risk factors for aneurysm growth and rupture.
Sideline Concussion Assessment: The Current State of the Art
Authors: Yue John K , Phelps Ryan R L , Chandra Ankush , Winkler Ethan A , Manley Geoffrey T , Berger Mitchel S 
Published: January 2020

AbstractMore than 200 million American adults and children participate in organized physical activity. Growing awareness has highlighted that concussion, especially when repeated, may be associated with prolonged neurological, cognitive, and/or neuropsychiatric sequelae. Objective diagnosis of concussion remains challenging. Although some concussion symptoms may be apparent even to nonmedical observers, diagnosis and removal from play for evaluation depend on validated assessment tools and trained, vigilant healthcare personnel. Over the past 2 decades, sideline concussion measures have undergone significant revision and augmentation to become more comprehensive batteries in order to detect a wide spectrum of symptomatology, eg, neurocognitive function, postconcussive symptoms, gait/balance, and saccadic eye movements. This review summarizes the current state-of-the-art concussion evaluation instruments, ranging from the Sports Concussion Assessment Tool (SCAT) and tools that may enhance concussion detection, to near-term blood-based biomarkers and emerging technology (eg, head impact sensors, vestibulo-ocular/eye-tracking, and mobile applications). Special focus is directed at feasibility, utility, generalizability, and challenges to implementation of each measure on-field and on the sidelines. This review finds that few instruments beyond the SCAT provide guidance for removal from play, and establishing thresholds for concussion detection and removal from play in qualification/validation of future instruments is of high importance. Integration of emerging sideline concussion evaluation tools should be supported by resources and education to athletes, caregivers, athletic staff, and medical professionals for standardized administration as well as triage, referral, and prevention strategies. It should be noted that concussion evaluation instruments are used to assist the clinician in sideline diagnosis, and no single test can diagnose concussion as a standalone investigation.
Associations Between Nicotine Metabolite Ratio and Gender With Transitions in Cigarette Smoking Status and E-Cigarette Use: Findings Across Waves 1 and 2 of the Population Assessment of Tobacco and Health (PATH) Study
Authors: Verplaetse Terril L , Peltier MacKenzie R , Roberts Walter , Moore Kelly E , Pittman Brian P , McKee Sherry A 
Published: January 2020

Abstract

Introduction
Nicotine metabolite ratio (NMR), the ratio of trans 3′-hydroxycotinine to cotinine, is a biomarker of nicotine metabolism. Discrepant findings among clinical trials and population-based studies warrant replication on whether higher NMR, or faster nicotine metabolism, is associated with quitting cigarette smoking. Associations of NMR and e-cigarette use are largely unknown, as well as the relationship between NMR and gender on quitting cigarette smoking or e-cigarette use.

Methods
The Population Assessment of Tobacco and Health (PATH) Study is a nationally representative, longitudinal cohort study assessing tobacco use in the US population. In the current study, the PATH (waves 1 and 2; adult interviews) was used to evaluate longitudinal predictions in relationships among NMR and gender and their association with transitions (quit vs. current stable) in cigarette smoking status and e-cigarette use status across waves 1 and 2 of the PATH study.

Results
NMR and gender were not significantly associated with quit behavior for combustible cigarettes. Regarding e-cigarettes, a significant two-way interaction demonstrated that women with higher NMR were less likely to quit e-cigarette use compared to women with lower NMR (odds ratio [OR] = 0.10, 95% confidence interval [CI] = 0.02–0.57; p = .01).

Conclusions
Findings identify that women with faster nicotine metabolism were 10 times less likely to quit e-cigarettes compared to women with slower nicotine metabolism across waves 1 and 2 of the PATH study. Results suggest that NMR may be used as a biomarker for transitions in e-cigarette quit behavior for women.

Implications
Findings identify that women with faster nicotine metabolism were 10 times less likely to quit e-cigarettes compared to women with slower nicotine metabolism. Results suggest that NMR may be used as a biomarker for transitions in e-cigarette quit behavior for women. Establishing parameters for NMR collection and for the use of NMR as a biomarker for cigarette smoking behavior and e-cigarette use is an important next step, and may have implications for early intervention and treatment for cessation.