bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of concomitant coronary artery bypass grafting on the outcomes of total arch repair with frozen elephant trunk for type A aortic dissection
Authors: Huang Ling-Chen , Zhang Ai-Kai , Hu Xiang-Ming , Shao Ze-Hua , Sun Yang-Xue , Zhao Dong , Chang Yi , Qian Xiang-Yang , Guo Hong-Wei 
Published: December 2024

Abstract

OBJECTIVES
Coronary artery bypass grafting (CABG) is often performed alongside type A aortic dissection (TAAD) repair. However, the association between concomitant CABG and the clinical outcomes of TAAD repair remains uncertain.

METHODS
This study included 1002 consecutive TAAD patients who underwent total aortic arch replacement (TAR) with frozen elephant trunk from June 2019 to January 2024. Concomitant CABG during TAR and frozen elephant trunk was performed under 3 conditions: planned CABG for coronary ostial involvement, planned CABG for coronary artery disease and rescue CABG. Patients who underwent rescue CABG (N = 42) were compared with those who had planned CABG (N = 218) and those who did not undergo CABG (non-CABG: N = 742). Logistic regression, Kaplan–Meier and Cox regression analyses were employed.

RESULTS
Operative mortality rate was 2.40%; 42 (4.19%) patients underwent rescue CABG. The rescue CABG group had the highest operative mortality (23.81%) among the 3 groups (P &lt; 0.001). Rescue CABG was associated with increased operative mortality compared with non-CABG [odds ratio: 18.96, 95% confidence interval (CI) 7.32–49.08, P &lt; 0.001], whereas planned CABG was not significant. The median follow-up period was 24.80 (interquartile range 11.73–39.10) months. Kaplan–Meier analysis demonstrated poorer overall survival in the rescue CABG group (log-rank P-value &lt; 0.001). Rescue CABG significantly increased all-cause late mortality compared with non-CABG (hazard ratio 13.69, 95% CI 6.53–28.70, P &lt; 0.001), while planned CABG did not. The 2-year cumulative incidence of graft occlusion among CABG patients was 24.54%.

CONCLUSIONS
Rescue CABG is significantly associated with increased operative and all-cause mortality in patients undergoing TAR and frozen elephant trunk for TAAD. Further research is required to identify the causes of rescue CABG.
Mediterranean diet, neutrophil count, and carotid intima-media thickness in secondary prevention: the CORDIOPREV study
Authors: Boughanem Hatim , Torres-Peña José D , Arenas-de Larriva Antonio Pablo , Romero-Cabrera Juan L , Gómez-Luna Purificación , Martín-Piedra Laura , Rodríguez-Cantalejo Fernando , Tinahones Francisco J , Yubero Serrano Elena M , Soehnlein Oliver , Perez-Martinez Pablo , Delgado-Lista Javier , López-Miranda José 
Published: December 2024

Abstract

Background and Aims
Several studies have supported the role of innate immune system as a key factor in the sterile inflammation underlying the pathophysiology of atherosclerosis in mice. However, its involvement in humans remains unclear. This study aimed to explore the association between neutrophil count, and the intima-media thickness of common carotid arteries (IMT-CC), as well as the potential impact of long-term dietary interventions on these associations.

Methods
A comprehensive analysis was conducted within the framework of the CORDIOPREV study, a long-term secondary prevention study involving dietary interventions with either a Mediterranean or a low-fat diet. The study evaluated the relationship between absolute neutrophil count and neutrophil-related ratios with IMT-CC at baseline and after 5 and 7 years of dietary intervention.

Results
At baseline, patients in the highest tertile of neutrophil count had a higher IMT-CC and number of carotid plaques, when compared to lowest tertile (P &lt; .01 and P &lt; .05, respectively). Logistic regression analyses supported this association. Elevated neutrophil count, neutrophil-to-erythrocyte ratio, and neutrophil-to-HDL ratio were associated with an increased likelihood of having an IMT-CC &gt;.9 mm {odds ratio (OR) 1.17 [95% confidence interval (CI) 1.04–1.35], OR 2.21 (95% CI 1.24–4.12), and OR 1.96 (95% CI 1.09–3.55), respectively}, after adjustment for all variables, which was corroborated by linear regression. Furthermore, a linear mixed-effect model analysis from a longitudinal analysis spanning 5 and 7 years revealed an increase in 1 unit of neutrophils/μl at these time points was associated with a mean increase of .004 (.002) mm in the IMT-CC (P = .031) after adjustment for all variables. Interestingly, in patients exhibiting regression in IMT-CC after 7 years of follow-up, those following a Mediterranean diet showed a significant decrease in neutrophil count after 5 and 7 years (both with P &lt; .05), compared to baseline.

Conclusions
These findings suggest that neutrophils may represent a promising target for preventing atherosclerosis. A Mediterranean diet could serve as an effective dietary strategy to reduce neutrophil levels and potentially slow the progression of atherosclerosis, offering a new neutrophil-reducing therapy concept. Further research is essential to gain deeper insights into the role of neutrophils in the pathophysiology of atherosclerotic cardiovascular disease in humans.
DOME Registry: implementing community-wide recommendations for reporting supervised machine learning in biology
Authors: Attafi Omar Abdelghani , Clementel Damiano , Kyritsis Konstantinos , Capriotti Emidio , Farrell Gavin , Fragkouli Styliani-Christina , Castro Leyla Jael , Hatos András , Lenaerts Tom , Mazurenko Stanislav , Mozaffari Soroush , Pradelli Franco , Ruch Patrick , Savojardo Castrense , Turina Paola , Zambelli Federico , Piovesan Damiano , Monzon Alexander Miguel , Psomopoulos Fotis , Tosatto Silvio C E 
Published: December 2024

Abstract
Supervised machine learning (ML) is used extensively in biology and deserves closer scrutiny. The Data Optimization Model Evaluation (DOME) recommendations aim to enhance the validation and reproducibility of ML research by establishing standards for key aspects such as data handling and processing, optimization, evaluation, and model interpretability. The recommendations help to ensure that key details are reported transparently by providing a structured set of questions. Here, we introduce the DOME registry (URL: registry.dome-ml.org), a database that allows scientists to manage and access comprehensive DOME-related information on published ML studies. The registry uses external resources like ORCID, APICURON, and the Data Stewardship Wizard to streamline the annotation process and ensure comprehensive documentation. By assigning unique identifiers and DOME scores to publications, the registry fosters a standardized evaluation of ML methods. Future plans include continuing to grow the registry through community curation, improving the DOME score definition and encouraging publishers to adopt DOME standards, and promoting transparency and reproducibility of ML in the life sciences.
The telomere-to-telomere (T2T) genome provides insights into the evolution of specialized centromere sequences in sandalwood
Authors: Peng Dan , Hong Zhou , Kan Shenglong , Wu Zhiqiang , Liao Xuezhu 
Published: December 2024

Abstract

Background
Sandalwood, a prized hemiparasitic plant, is highly sought in the commercial market because of its aromatic core materia. The structure and stability of the genome are instrumental in the rapid adaptation of parasitic plants to their surroundings. However, there is a conspicuous lack of research on the genomic-level adaptive evolution of sandalwood.

Results
In this study, we assembled a gap-free telomere-to-telomere (T2T) reference genome for Santalum album using PacBio HiFi, Hi-C, and ultra-long ONT data. The T2T reference genome (Sal_t2t) encompassed annotations of 24,171 genes and 25.34% repetitive sequences, in addition to all 10 centromeres and 20 telomeres across the 10 chromosomes. The results revealed that the 3 distinct parasitic species of Santalales had diverse centromeric compositions. The Copia-type long terminal repeat transposon emerged as the most significant in the S. album genome, constituting the primary sequence of the centromere and influencing gene expression. Third, in sandalwood, the presence of Copia affected the size of the centromeres and, consequently, the genome size. Identification of the sandalwood T2T genome in this study also enabled the identification of more precise organelle transfer fragments.

Conclusions
Our research provides a sandalwood T2T genome, laying the groundwork for future investigations on the evolution of energy organs in parasitic plants. Moreover, it offers novel insights into the function and evolution of centromeres, as well as the mechanisms of adaptation and parasitism.
Joint inversion of full-waveform ambient noise and gravity data for simultaneously deriving high-resolution three-dimensional crustal S-wave velocity and density models: application to the Jingpohu volcanic area in Northeast China
Authors: Guo Lianghui , Bao Xueyang , Shen Yang , Chen Yang , Han Mei 
Published: December 2024

SUMMARY
Both crustal velocity and density models provide important constraints for understanding crustal tectonics, composition and magmatic system. However, conventional gravity inversion methods for density models are troubled by poor depth-resolution and non-uniqueness. We apply a joint inversion method to full-waveform ambient noise and gravity data for simultaneously deriving high-resolution 3-D crustal S-wave velocity (Vs) and density models. By constraints of seismic and gravity data, our joint inversion could significantly improve the resolution of density models and reduce the uncertainty on the inversion results. Our method is suitable for any areas especially with low seismicity and can be extended to basin-scale. We apply the method on the seismic and gravity data around the Jingpohu (JPH) volcanic area in Northeast China to obtain high-resolution 3-D crustal Vs and density models, which are subsequently used to build the crustal lithological model. Our models demonstrate that the JPH volcanic group is located near the junction of the Mudanjiang–Yilan and Dunhua–Mishan fault zones and was tectonically controlled by them. A steep crustal-scale mafic intrusion with high Vs and density is present beneath the JPH volcanic group, and we interpret it as the same product as the JPH volcanic basaltic rocks outcropped on the surface by the mantle-sourced magmatic upwelling. Furthermore, none significant molten magma reservoirs with low Vs and density are observed currently within the crust of the JPH volcanic group. Thus, our results support that the JPH volcanic group is a single volcanic genesis with a mantle-only magma source.
The role of value references in shaping cultures of engagement: evidence from COVID-19 news on Facebook in Romania and the U.K.
Authors: Monzer Cristina , Dimitrova Daniela V 
Published: December 2024

Abstract
Values are consequential for opinion formation and remain a persuasive factor in shaping public attitudes. Still, the role of values remains under-researched in the context of online news production and engagement. This study investigates the intricate role values play by analyzing patterns of value references in online news coverage of coronavirus disease 2019 (COVID-19) in two culturally distinct nations, Romania and the U.K. Conceptually, the study is based on Schwartz’s value typology; methodologically, it relies on the Concept Mover’s Distance method. Analyzing half a million Facebook posts, the study identifies four types of value references: universal, cultural, topic-based, and situational. We show that cultural values prevalent in British posts, such as stimulation and tradition, resonate with the culturally congruent context. Universal values, however, do not guarantee a high level of engagement. The findings underscore the nuanced impact of values in shaping online news engagement.
Health literacy enhancement through food guide and hygiene education: a study among Taiwanese students
Authors: Chang Tsai-Ju , Wu Yi-Ching , Chau Chi-Fai 
Published: December 2024

Abstract
The World Health Organization defined health as ‘a condition of full physical, mental and social well-being’. Nutrition and food safety are intertwined and two of the most influential determinants of human health. This study primarily aimed to design and implement a specialized curriculum focused on food hygiene, and Taiwan’s daily food guide to enhance health literacy among junior high students in Taiwan. A student-centered approach, based on active learning and constructivist principles, was used to engage students in interactive discussions and hands-on activities related to dietary guidelines and food hygiene. Four classrooms, with a total of 92 students, participated in this study. The students were randomized into a control group (n = 46) and an experimental group (n = 46). The average age ranged from 13 to 15 years. An illustrated questionnaire underwent pilot testing and expert review, followed by pre- and post-intervention assessments to measure knowledge improvements. The results showed a significant connection between the Taiwan daily food guide and health literacy. Although food hygiene education played a lesser role, the intervention improved students’ health literacy, supporting positive health outcomes. In addition, recognizing the lack of suitable assessment tools in this field, we developed a reliable and valid illustrated questionnaire to measure the effectiveness of the intervention and track changes in students’ knowledge. The questionnaire demonstrated high internal consistency (Cronbach’s alpha of 0.883) and strong inter-rater reliability (intraclass correlation factor above 0.7), confirming its effectiveness as a tool for educational research.
How are pro- and anti-cannabis messaging exposures related to US young adult cannabis use-related factors?
Authors: Cui Yuxian , LoParco Cassidy R , Romm Katelyn F , Cavazos-Rehg Patricia A , Yang Y. Tony , McCready Darcey M , Kasson Erin , Wang Yan , Berg Carla J 
Published: December 2024

Abstract
Given the diverse sources of cannabis messaging and potential differential effects, this study examined pro- and anti-cannabis messaging exposure overall and via specific channels in relation to cannabis-related perceptions (social acceptability and harm) and behaviors (use status, intentions and frequency; past-year quit attempts). Multivariable regression analyses of 2023 survey data from 4031 US young adults (Mage = 26.29, 59.4% female, 19.0% Hispanic, 13.5% Black and 13.6% Asian) used independent variables representing overall exposure and via specific sources (stores, online, billboards/posters/flyers, TV/movies/radio, print and direct communication), respectively. Greater pro-cannabis messaging exposure correlated with greater perceived social acceptability, lower perceived harm, past-month use, greater use intentions among those reporting past-month nonuse and more days used and fewer quit attempts among those reporting use. Less anti-cannabis messaging exposure correlated with these outcomes, except intentions. Particularly, influential sources of pro-cannabis messaging were online (associated with perceptions, use status, intentions and frequency) and direct communication (perceptions, use, use frequency and quit attempts), and those of anti-cannabis messaging were online (harm and use intentions), direct communication (acceptability, quit attempts) and stores (perceptions, use and quit attempts). Exposure differed by sociodemographics (e.g. sex, race/ethnicity and education). The impact of digital media and targeted communications overall and stores in communicating cannabis-related risks suggest the need for regulation and monitoring.
A qualitative analysis of factors influencing physical activity behaviour in women with PCOS: key learning for physical activity interventions and beyond
Authors: Woodward Amie , Klonizakis Markos , Broom David , Cholerton Rachel , Piercy Hilary 
Published: December 2024

Abstract
Physical activity (PA) is recommended in clinical practice guidelines as effective for the management of polycystic ovary syndrome (PCOS). However, adherence to PA interventions is low in this population, and long-term uptake of PA is a challenge. We conducted a feasibility trial of two PA interventions for women with PCOS. This paper reports a qualitative evaluation of the trial in tandem with an evaluation of barriers and facilitators to PA in a sub-group of participants. Eleven participants with PCOS were purposively sampled from the main sample (n = 36) and participated in semi-structured interviews. Interviews were audio-recorded and transcribed verbatim. Data were analysed using reflexive thematic analysis. Five themes were developed relating to experiences of the intervention and factors influencing PA behaviour: (1) The Changing Nature of Priorities, (2) The Push and Pull of PCOS Symptoms, (3) Focusing Beyond the Scale, (4) Knowledge as a Foundation for Change and (5) The Balance of Stigma and Social Support. These findings can be used to design PA interventions that consider the interplay between PCOS and PA behaviour to achieve health benefits beyond short-term interventions.
Silent uncrewed surface vehicles reveal the diurnal vertical distribution of lesser sandeel
Authors: Komiyama Sakura , Holmin Arne Johannes , Pedersen Geir , Johnsen Espen 
Published: December 2024

Abstract
Lesser sandeel (Ammodytes marinus) exhibits a peculiar diel vertical migration (DVM) during the feeding season, burying into the seabed at night and emerging during daytime to form schools that feed on zooplankton. Large schools may consist of a pelagic component searching for prey and a bottom component connected by collective bridge-like formations. However, the temporal variation in the schools’ vertical distribution is poorly understood. In this study, 38 and 200 kHz acoustic data recorded with Saildrones were used to examine the schooling dynamics during their main feeding season in May–June. A total of 1497 sandeel schools that were identified by linear discriminant analysis displayed two distinct vertical components throughout the season: one in the pelagic zone and one near the seabed. The pelagic component was distributed deepest at noon and had a similar pattern to zooplankton DVM, suggesting that sandeel followed the vertical distribution of their prey. Their diurnal ascension was greater in both distance and hours in May than June, suggesting a decline in feeding motivation towards the end of the feeding season. These findings were made possible with the long-term monitoring by silent Saildrones, which did not seem to affect the natural behaviour of sandeel schools.
Mangrove restoration reinstates similar macrobenthos communities to natural mangroves in Guyana, South America
Authors: Ram Mark , Sheaves Marcus , Waltham Nathan J 
Published: December 2024

Abstract
Mangrove restoration projects have become increasingly widespread to compensate for mangrove loss. Despite considerable investment in this restoration activity, post-restoration monitoring is often limited to vegetation recovery with no inclusion of faunal groups, such as macrobenthos communities, even though these groups are excellent bioindicators. Here, we used a space-for-time approach to examine whether restored mangrove macrobenthos communities are equivalent to natural mangroves of the same age (5–11 years after colonization). We focused our analyses on sediment samples collected from the lower, middle, and upper intertidal zones of restored and natural mangroves in the dry and wet seasons, along Guyana’s coastline, South America. We observed an overall higher macrobenthos abundance in the natural mangroves compared to restored mangrove areas, which contrasted with higher species richness in the restored mangroves compared to natural mangroves. Nonmetric multidimensional scaling, analysis of similarities, and similarity percentage analysis revealed that macrobenthos species composition was not significantly different among the restored and natural mangrove habitats, ages, and seasons (P &gt; .05). This suggests that the macrobenthos composition in restored mangrove areas quickly converges, after restoration activities, with communities observed in natural mangroves. Our findings indicate that, at least for biodiversity outcomes, macroinvertebrate communities occupying sediments in restored mangroves resemble natural areas rapidly post-restoration efforts.
Comparison of pulmonary and aortic root and cusp dimensions in normal adults using computed tomography: potential implications for Ross procedure planning
Authors: Jelenc Matija , Jelenc Blaž , Habjan Sara , Abeln Karen B , Fries Peter , Michelena Hector I , Schäfers Hans Joachim 
Published: December 2024

Abstract

OBJECTIVES
The Ross procedure is currently receiving renewed interest. Its function and durability depend on preservation of pulmonary valve anatomy; limited data exist on normal pulmonary valve geometry. The objective was to compare aortic and pulmonary root and cusp dimensions in adults with normal tricuspid aortic and pulmonary valves.

METHODS
We reviewed 507 coronary computed tomography studies, selecting those with adequate visibility of both pulmonary and aortic roots for further analysis. Diastolic aortic and pulmonary root and cusp dimensions were measured. Root dimensions at different phases of the cardiac cycle were measured in 3 patients.

RESULTS
We analysed studies of 50 patients with the mean age of 54 years [standard deviation (SD): 16]. In end-diastole, pulmonary root had a smaller sinutubular to basal ring ratio than the aortic root [0.82 (SD: 0.09) vs 1.14 (SD: 0.12), P &lt; 0.001]. Aortic and pulmonary cusps had similar dimensions; however, pulmonary cusp effective height was lower [5.9 mm (SD: 1.6) vs 8.4 mm (SD: 1.2), P &lt; 0.001]. Pulmonary basal ring perimeter was largest at end-diastole and smallest at end-systole, with the relative difference of 23.5% (SD: 2.7).

CONCLUSIONS
The pulmonary root has a similar cusp size compared to the aortic root, but a different shape, resulting in a lower pulmonary cusp effective height. The perimeter of the pulmonary basal ring changes during the cardiac cycle. These findings suggest that stabilizing the autograft to normal aortic, rather than pulmonary, root dimensions should result in normal autograft cusp configuration. Computed tomography angiography could become a tool for personalized planning of the Ross procedure.
Urbicide and Coming to Terms with the Past: Everyday Acts of Return and Reconstruction in Post-war Nahr el Bared
Authors: Sobout Azadeh 
Published: December 2024

ABSTRACT∞
The violent destruction of Nahr el Bared refugee camp – the second biggest Palestinian camp in Lebanon – in 2007 and its community’s efforts to reclaim justice through post-war reconstruction make it a compelling case to study the intersection of urbicide and transitional justice. Utilizing the concept of grassroots transitional justice and building on recent scholarship on urban warfare and urbicidal violence, this article examines how Palestinians of Nahr el Bared have developed creative infrastructures of justice in extreme conditions of urbicide. By shedding light on urbicide as a form of political violence and its role in producing violations of human rights – particularly those related to socio-economic rights, displacement and destruction of space, memory and identity – the article suggests that post-war reconstruction can and should be viewed as a matter of justice. Linking the concepts of urbicide, transitional justice and post-war reconstruction, the article explores a model of transitional justice that engages with restoration of truth, memorialization and governance in the post-war reconstruction process. By highlighting narratives, stories and memories that focus on the destruction, the siege, the suspended home and the need for return, memorialization and reconstruction, the article explores the grassroots conception of justice for the displaced Palestinian community and examines how transitional justice might be reconfigured in the aftermath of urbicide.