bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fault Model of the 1804 Kisakata Earthquake (Akita, Japan)
Authors: Imai Kentaro , Okada Shinsuke , Takahashi Narumi , Ebina Yuichi , Tsuji Yoshinobu 
Published: July 2020

AbstractThe 10 July 1804 Kisakata earthquake occurred offshore Kisakata (Akita, Japan), and widespread felt shaking was reported from Matsumae (Hokkaido) to Ohmi-Hachiman (Shiga Prefecture). The earthquake caused strong ground motions that extensively damaged areas near the epicenter, such as along the coast of Kisakata, and the resultant tsunami caused extensive damage along the coast from Kisakata to Sakata. Furthermore, Kisakata lagoon was uplifted by dislocation during the earthquake, exposing the lagoon floor. Here, we performed a field survey of the uplift distribution based on microtopographic remnants of the former shoreline of Kisakata lagoon and used historical documents to re-evaluate tsunami trace heights. Using ocean-bottom reflection profiles, we estimated a fault model for the earthquake and resultant tsunami. Our model indicates that an average of 5.6 m of slip on the fault (equivalent to an Mw 7.1 earthquake) is required to explain the observed crustal deformation and tsunami height distributions, and back correction of the modeled slip reproduced well the former shoreline of Kisakata lagoon.
An Automated Method for Developing a Catalog of Small Earthquakes Using Data of a Dense Seismic Array and Nearby Stations
Authors: Cheng Yifang , Ben-Zion Yehuda , Brenguier Florent , Johnson Christopher W. , Li Zefeng , Share Pieter-Ewald , Mordret Aurélien , Boué Pierre , Vernon Frank 
Published: July 2020

AbstractWe propose a new automated procedure for using continuous seismic waveforms recorded by a dense array and its nearby regional stations for P-wave arrival identification, location, and magnitude estimation of small earthquakes. The method is illustrated with a one-day waveform dataset recorded by a dense array with 99 sensors near Anza, California, and 24 surrounding regional stations within 50 km of the dense array. We search a wide range of epicentral locations and apparent horizontal slowness values (0–15  s/km) in the 15–25 Hz range and time shift the dense array waveforms accordingly. For each location–slowness combination, the average neighboring station waveform similarity (avgCC) of station pairs &lt;150  m apart is calculated for each nonoverlapping 0.5 s time window. Applying the local maximum detection algorithm gives 966 detections. Each detection has a best-fitting location–slowness combination with the largest avgCC. Of 331 detections with slowness &lt;0.4  s/km, 324 (about six times the catalog events and 98% accuracy) are found to be earthquake P-wave arrivals. By associating the dense array P-wave arrivals and the P- and S-wave arrivals from the surrounding stations using a 1D velocity model, 197 detections (∼4 times of the catalog events) have well-estimated locations and magnitudes. Combining the small spacing of the array and the large aperture of the regional stations, the method achieves automated earthquake detection and location with high sensitivity in time and high resolution in space. Because no preknowledge of seismic-waveform features or local velocity model is required for the dense array, this automated algorithm can be robustly implemented in other locations.
The impact of bismuth adding to rabeprazole, amoxicillin and clarithromycin on eradication rate of Helicobacter pylori
Authors: Sadrkabir Mohammad , Tasouji Masoud , Sharghi Afshan , Yazdanbod Abbas 
Published: July 2020

Background: High prevalence of Helicobacter pylori infection and induction of resistance as a result of consumption of antibiotics necessitates an ongoing effort for evaluation of new regimen to overcome this phenomenon. Intensive efforts are being made to identify such an optimal regimen, but there are many obstacles hindering the achievement of this goal. This study aimed to investigate the impact of adding bismuth to rabeprazole, amoxicillin and clarithromycin on rate of H. pylori eradication.Methods: In this randomized clinical trial, 60 patients with dyspepsia and positive gastric biopsy for H. pylori in endoscopy were recruited. The first group (A) received rabiprazole for 6 weeks, amoxicillin and clarithromycin for 2 weeks either with bismuth for 2 weeks and the second group (B) received rabiprazole for 6 weeks, amoxicillin and clarithromycin for 2 weeks either without bismuth. Four weeks after the treatment, the compliance and eradication were evaluated using stool antigen of helicobacter. The patients who could complete the therapeutic regimen were assigned for analysis.Results: H. pylori eradication rates were 70% and 56.6% in two groups A and B (with and without Bismuth), respectively and the difference was significant. There is a significant relationship between the studied groups and the results of fecal antigen of H. pylori.Conclusions: The bismuth had a significant effect on the success of eradication rate of H. pylori and its impact adding to the treatment regimen containing clarithromycin was effective on eradication success rate.
Mephentermine abuse of prescription drugs in gym
Authors: Bhardwaj Ankit , Sharma Sangeeta , Prakash Om 
Published: July 2020

A case report of 32 years old male presented to the drug addiction OPD and treatment center for the withdrawal symptoms of mephentermine. Mephentermine a synthetic derivative of amphetamines with cardiac stimulatory action is been misused for boast of endurance in bodybuilders. Abuse of mephentermine result in psychosis, cardiovascular disorder and development of tolerance and dependence over time. Given its potential of causing harm, the abuse and dependence liability of mephentermine needs to be highlighted to gym instructors and general public.
Tumor de cordón sexual con túbulos anulares y cistadenoma mucinoso de ovario, en una adolescente con Síndrome de Peutz Jeghers
Authors: López Corella Eduardo , Garza Elizondo Rosalía , Silva Martínez María Teresa , González del Ángel Ariadna , Fuentes-Gutiérrez Denisse 
Published: July 2020

Niña de 14 años que acudió a nuestro Instituto al año de vida por prolapso de pólipo rectal con evacuaciones sanguinolentas. Segunda gesta de una pareja de padre sano y madre afectada con el síndrome de Peutz-Jeghers, al igual que otros familiares por la rama materna. Existe antecedente de aborto en la madre y tiene una hermana menor aparentemente sana. La madre presentó amenaza de parto pretérmino en el séptimo mes que se controló con reposo y medicamentos no especificados. La paciente nació por cesárea a las 41 semanas de edad gestacional, por falta de trabajo de parto. Presentó llanto y respiración espontáneos, APGAR de 8-9, peso 3.800 Kg, talla 51 cm. Fue dada de alta como binomio sano a las 78 horas. El periodo postnatal curso sin complicaciones y su desarrollo neurológico fue normal.
Apofisitis de la Rodilla (Osgood Schlatter, Sinding Larsen Johansson)
Authors: Unda Haro José Pablo , Migoya Nuño Alfonso , Capuano Tripp Pola 
Published: July 2020

Las apofisitis por tracción son lesiones por sobre uso que se presentan exclusivamente en el paciente pediátrico como resultante del micro trauma repetitivo generado por la tracción de los tendones a nivel de las apófisis, principalmente durante la fase rápida de crecimiento en pacientes que practican actividades deportivas, ya que durante este periodo el crecimiento óseo y muscular no son armónicos, los tendones relativamente cortos generan mayor fuerza de tracción sobre las apófisis creando cargas submaximas de tracción repetida causante de inflamación y lesión de las apófisis.; las apofisitis por tracción en la rodilla son Osgood Schlatter y Sinding Larsen Johansson
Study on Secondary Cable Adjustment for Cable-stayed Bridges Without back Cables
Authors: Sun Zengshou , Liu Xiaocong , Ma Jianfeng 
Published: July 2020

<p>The structure of cable-stayed bridge without back cable is a new breakthrough.In this paper, the cable adjustment process of linzhou yingbin bridge is studied. the whole bridge model is established using the finite element software MIDAS CIVIL.This paper compares the measured cable force with the designed cable force and gets range of cable force difference, The influence matrix method is used for the second cable adjustment to ensure that the stress and structural deformation in the process of cable adjustment are within the range of the design requirements.The cable force variation of the whole bridge is detected by dynamic measuring instrument to ensure the construction safety in the process of cable adjustment.</p><p> </p>
Evaluations of Bole Injections for Protecting Engelmann Spruce from Mortality Attributed to Spruce Beetle (Coleoptera: Curculionidae) in the Intermountain West
Authors: Fettig Christopher J. , Munson A. Steven , Grosman Donald M. , Blackford Darren C. 
Published: July 2020

AbstractBark beetles are important disturbance agents in coniferous forests, and spruce beetle, Dendroctonus rufipennis (Kirby) (Coleoptera: Curculionidae), is one of the more notable species causing landscape-level tree mortality in western North America. We evaluated the efficacy of bole injections of emamectin benzoate (TREE-äge®; Arborjet Inc., Woburn, MA) alone and combined with propiconazole (Alamo®; Syngenta Crop Protection Inc., Wilmington, DE) for protecting Engelmann spruce, Picea engelmannii Parry ex Engelmann (Pinales: Pinaceae), from mortality attributed to colonization by D. rufipennis. Two injection periods in 2013 (the spring and fall of the year prior to trees first being challenged by D. rufipennis in 2014) and distributions of injection points (7.6- and 15.2-cm spacings) were evaluated. Tree mortality was monitored over a 3-yr period (2014–2017). Emamectin benzoate injected in spring at a narrow spacing (7.6 cm) was the only effective treatment. Two (but not three) field seasons of protection can be expected with a single injection of this treatment. We discuss the implications of these and other results regarding the use of emamectin benzoate and propiconazole for protecting western conifers from mortality attributed to bark beetles, and provide suggestions for future research. A table summarizing the appropriate timing of treatments in different bark beetle/host systems is provided.
Genome-wide detection and sequence conservation analysis of long non-coding RNA during hair follicle cycle of yak
Authors: Zhang Xiaolan , Bao Qi , Jia Congjun , Li Chen , Chang Yongfang , Wu Xiaoyun , Liang Chunnian , Bao Pengjia , Yan Ping 
Published: July 2020

Abstract
Background: Long non-coding RNA (lncRNA) as an important regulator has been demonstrated playing an indispensable role in the biological process of hair follicles (HFs) growth. However, their function and expression profile in the HFs cycle of yak are yet unknown. Only a few functional lncRNAs have been identified, partly due to the low sequence conservation and lack of identified conserved properties in lncRNAs. Here, lncRNA-seq was employed to detect the expression profile of lncRNAs during the HFs cycle of yak, and the sequence conservation of two datasets between yak and cashmere goat during the HFs cycle was analyzed. Results: A total of 2884 lncRNAs were identified in 5 phases (Jan., Mar., Jun., Aug., and Oct.) during the HFs cycle of yak. Then, differential expression analysis between 3 phases (Jan., Mar., and Oct.) was performed, revealing that 198 differentially expressed lncRNAs (DELs) were obtained in the Oct.-vs-Jan. group, 280 DELs were obtained in the Jan.-vs-Mar. group, and 340 DELs were obtained in the Mar.-vs-Oct. group. Subsequently, the nearest genes of lncRNAs were searched as the potential target genes and used to explore the function of DELs by GO and KEGG enrichment analysis. Several critical pathways involved in HFs development such as Wnt signaling pathway, VEGF signaling pathway, and signaling pathways regulating pluripotency of stem cells, were enriched. To further screen key lncRNAs influencing the HFs cycle, 24 DELs with differ degree of sequence conservation were obtained via a comparative analysis of partial DELs with previously published lncRNA-seq data of cashmere goat in the HFs cycle using NCBI BLAST-2.9.0+, and 3 DELs of them were randomly selected for further detailed analysis of the sequence conservation properties.Conclusions: This study revealed the expression pattern and potential function of lncRNAs during HFs cycle of yak, which would expand the knowledge about the role of lncRNAs in the HFs cycle. The findings related to sequence conservation properties of lncRNAs in the HFs cycle between the two species may provide valuable insights into the study of lncRNA functionality and mechanism.
Conquering Hypertension in Vietnam- Solutions at Grassroots Level: Study Protocol of a Cluster Randomized Controlled Trial
Authors: Ha Duc , Tran Oanh , Nguyen Hoa , Goldberg Robert , Chiriboga German , Phan Van , Nguyen Cuc , Nguyen Giang , Pham Hien , Nguyen Thang , Le Thanh , Allison Jeroan 
Published: July 2020

Abstract
BackgroundVietnam has been experiencing an epidemiologic transition to that of a low-middle income country with an increasing prevalence of non-communicable diseases. The key risk factors for cardiovascular disease (CVD) are either on the rise or at alarming levels in Vietnam, particularly hypertension (HTN). Inasmuch, the burden of CVD will continue to increase in the Vietnamese population unless effective prevention and control measures are put in place. The objectives of the proposed project are to evaluate the implementation and effectiveness of two multi-faceted community and clinic-based strategies on the control of elevated blood pressure (BP) among adults in Vietnam via a cluster-randomized trial design. MethodsSixteen communities will be randomized to either an intervention (8 communities) or comparison group (8 communities). Eligible and consenting adult study participants with HTN (n = 680) will be assigned to intervention/comparison status based on the community in which they reside. Both comparison and intervention groups will receive a multi-level intervention modeled after the Vietnam National Hypertension Program including education and practice change modules for health care providers, accessible reading materials for patients, and a multi-media community awareness program. In addition, the intervention group only will receive three carefully selected enhancements integrated into routine clinical care: (1) expanded community health worker services; (2) home blood pressure (BP) self-monitoring; and (3) a “storytelling intervention.”. which consists of interactive, literacy-appropriate, and culturally sensitive multimedia storytelling modules for motivating behavior change through the power of patients speaking in their own voice. The storytelling intervention will be delivered by DVD, with serial installments at baseline and at 3, 6, and 9 months after trial enrollment. Changes in BP will be assessed in both groups at several follow-up time points. Implementation outcomes will be assessed as well.DiscussionResults from this full-scale trial will provide health policy makers with practical evidence on how to combat a key risk factor for CVD using a feasible, sustainable, and cost-effective intervention that could be used as a national program for controlling HTN in Vietnam.Trial registration: ClinicalTrials.gov. Registration number: https://clinicaltrials.gov/ct2/show/NCT03590691 (registration date July 17, 2018).Protocol version: 6. Date: 08/15/2019
Effectiveness of switching between TNF inhibitors in patients with axial spondyloarthritis: is the reason to switch relevant?
Authors: Manica Santiago Rodrigues , Sepriano Alexandre , Pimentel-Santos Fernando M , Gouveia Nélia , Barcelos Anabela , Branco Jaime , Bernardes Miguel , Ferreira Raquel Miriam , Vieira-Sousa Elsa , Barreira Sofia , Vinagre Filipe , Roque Raquel , Santos Helena , Madeira Nathalie , Rovisco João , Daniel Alexandra , Ramiro Sofia 
Published: July 2020

Abstract
Background: To investigate whether the reason to discontinue the first TNF inhibitor (TNFi) affects the response to a second TNFi in axial spondyloartrhtis (axSpA).Methods: Patients with axSpA from the Rheumatic Diseases Portuguese Register (ReumaPt), who discontinued their first TNFi and started a second TNFi between June 2008 and May 2018 were included. Response was assessed by the Ankylosing Spondylitis Disease Activity Score (ASDAS) clinically important improvement (ASDAS-CII), major important improvement (ASDAS-MI), low disease activity (ASDAS-LDA) and inactive disease (ASDAS-ID). The reason for discontinuation of the first TNFi was defined, according to ASDAS-CII as: primary failure (no response ≤6 months); secondary failure (response ≤6 months but lost thereafter); adverse events; other. The association between the reason of discontinuation of the first TNFi and response to the second TNFi over time was assessed in multivariable generalized equation (GEE) models.Results: In total, 193 patients were included. The reason of discontinuation of the first TNFi did not influence the response to a second TNFi, according to the ASDAS-CII. However, a difference was found with more stringent outcomes, e.g. there was a higher likelihood to achieve ASDAS-ID with the second TNFi for patients discontinuing the first TNFi due to secondary failure (OR: 7.3 [(95%CI: 1.9; 27.7]), adverse events (OR: 9.1 [2.5; 33.3]), or other reasons (OR: 7.7 [1.6; 37.9]) compared to primary failure.Conclusion: Patients with axSpA with secondary failure to their first TNFi, compared to those with primary failure, have better response to the second TNFi according to stringent outcomes.
Skin Rash Following Administration of Apalutamide in Japanese Patients with Advanced Prostate Cancer: An Integrated Analysis of the Phase 3 SPARTAN and TITAN Studies and a Phase 1 Open-Label Study
Authors: Uemura Hiroji , Koroki Yosuke , Iwaki Yuki , Imanaka Keiichiro , Kambara Takeshi , Lopez-Gitlitz Angela , Smith Andressa , Uemura Hirotsugu 
Published: July 2020

Abstract
Background: A higher incidence of apalutamide-related skin rash has been observed in Japanese patients with prostate cancer (PC). Methods: This integrated analysis of data of Japanese patients from 2 global Phase 3 studies, SPARTAN (NCT01946204; patients with non‑metastatic castration-resistant PC [nmCRPC]) and TITAN (NCT02489318; patients with metastatic castration-sensitive PC [mCSPC]), and the Phase 1 study 56021927PCR1008 (NCT02162836; patients with metastatic CRPC [mCRPC]), assessed clinical risk factors of apalutamide-related skin rash as well as the potential correlation with plasma exposure to apalutamide. Kaplan-Meier method was used for time-to-event analyses. Clinical risk factors for skin rash were assessed using odds ratio. Results: Data from 68 patients ( SPARTAN: n=34, TITAN: n=28, 56021927PCR1008: n=6) receiving apalutamide 240 mg orally once-daily were analyzed. Rash (13 [19.1%]) and maculo-papular rash (11 [16.2%]) were the most frequently reported skin rash. All Grade and Grade 3 skin rash occurred in 35 (51.5%) and 10 (14.7%) patients, respectively. Most (85.7%) skin rash occurred within 4 months of apalutamide initiation and resolved in a median time of 1 month following the use of antihistamines, topical or systemic corticosteroids, with/without apalutamide dose interruptions/reductions. Median time-to-remission of first incidence of rash and maximum grade incidence of rash were 1.0 month (IQR: 0.36-1.81) and 1.0 month (IQR: 0.30-2.43), respectively. No significant clinical risk factors for the incidence of skin rash were observed. Areas under the curve (0-24 hours) (AUC 0-24, ss ) at steady‑state of plasma apalutamide concentration were numerically slightly higher in patients with skin rash than those without. Conclusions: No clinical risk factors for rash could be detected. There is a potential correlation between incidence of skin rash and plasma exposure to apalutamide. In general, apalutamide‑related skin rash is easily managed, with appropriate treatment with or without dose adjustment.
Influence of chronic kidney disease on early clinical outcomes after off-pump coronary artery bypass grafting
Authors: Li Xihui , Zhang Siyu , Xiao Feng 
Published: July 2020

Abstract
Background: Patients with chronic kidney disease (CKD) have a high incidence of coronary heart disease, which is the leading cause of death in these patients. Coronary artery bypass grafting (CABG) significantly increases short-term mortality and decreases long-term mortality in patients with CKD compared with percutaneous coronary intervention (PCI). The effect of CKD on the early outcomes of off-pump CABG is not well-studied. We aimed to investigate the effect of CKD on early postoperative mortality and complications following CABG. Methods: We retrospectively analyzed preoperative baseline and surgery data for 1173 patients undergoing off-pump CABG from January 2010 to December 2017 in the Department of Cardiac Surgery, Peking University First Hospital. Outpatient follow-up was performed until 30 days postoperatively. Patients with estimated glomerular filtration rates calculated according to the Chronic Kidney Disease Epidemiology Collaboration equation of ≥ 60 mL/min/1.73 m2 were assigned to the normal renal function group (normal group, n=924), and those with a rate < 60 mL/min/1.73 m2 were assigned to the CKD group (CKD group, n=249). Results: Patients in the CKD group were seriously ill with multiple complications, and postoperative 30-day mortality and complication rates were significantly higher than those in the normal group. In the logistic regression analysis, after correcting for common confounding factors, namely sex, age, and left ventricular ejection fraction, preoperative CKD was a risk factor for postoperative acute kidney injury, perioperative myocardial infarction, gastrointestinal bleeding, secondary tracheal intubation, stroke, chest wound infection, prolonged mechanical ventilation (≥ 24 h), prolonged intensive care unit stay (≥ 72 h), prolonged length of stay (≥ 14 d), dialysis requirement, and postoperative death within 30 days.Conclusions: Patients with CKD had more preoperative complications, and their postoperative 30-day mortality and complication rates after off-pump CABG were significantly higher than those of patients with normal renal function. For CABG patients with CKD, the risk of surgery should be assessed carefully, and comprehensive measures should be taken to strengthen perioperative management, with an aim to reduce complications and mortality and improve surgical outcomes.