bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review and meta‐analysis of wind turbine noise effects on sleep using validated objective and subjective sleep assessments
Authors: Liebich Tessa , Lack Leon , Hansen Kristy , Zajamšek Branko , Lovato Nicole , Catcheside Peter , Micic Gorica 
Published: November 2020

AbstractLittle is known about the potential impacts of wind turbine noise (WTN) on sleep. Previous research is limited to cross‐sectional studies reporting anecdotal impacts on sleep using inconsistent sleep metrics. This meta‐analysis sought to comprehensively review studies evaluating the impact of WTN using widely accepted and validated objective and subjective sleep assessments. Search terms included: “wind farm noise”, “wind turbine noise”, “wind turbine sound”, “wind turbine noise exposure” AND “sleep”. Only original articles published in English published after the year 2000 and reporting sleep outcomes in the presence of WTN using polysomnography, actigraphy or psychometrically validated sleep questionnaires were included. Uniform outcomes of the retrieved studies were meta‐analysed to examine WTN effects on objective and subjective sleep outcomes. Nine studies were eligible for review and five studies were meta‐analysed. Meta‐analyses (Hedges’ g; 95% confidence interval [CI]) revealed no significant differences in objective sleep onset latency (0.03, 95%  CI −0.34 to 0.41), total sleep time (−0.05, 95%  CI −0.77 to 0.67), sleep efficiency (−0.25, 95%  CI −0.71 to 0.22) or wake after sleep onset (1.25, 95%  CI −2.00 to 4.50) in the presence versus absence of WTN (all p > .05). Subjective sleep estimates were not meta‐analysed because measurement outcomes were not sufficiently uniform for comparisons between studies. This systematic review and meta‐analysis suggests that WTN does not significantly impact key indicators of objective sleep. Cautious interpretation remains warranted given variable measurement methodologies, WTN interventions, limited sample sizes, and cross‐sectional study designs, where cause‐and‐effect relationships are uncertain. Well‐controlled experimental studies using ecologically valid WTN, objective and psychometrically validated sleep assessments are needed to provide conclusive evidence regarding WTN impacts on sleep.
Association of IL‐10 gene promoter polymorphisms with food allergy susceptibility and serum IL‐10 level in a pediatric Caucasian population
Authors: Nedelkopoulou Natalia , Taparkou Anna , Raftopoulou Sofia , Gidaris Dimos , Xinias Ioannis , Mavroudi Antigoni , Dhawan Anil , Farmaki Evangelia 
Published: November 2020

AbstractBackgroundInterleukin 10 has been shown to play a critical role in the regulation of the immune responses in allergic diseases.AimTo investigate if genetic polymorphisms in the promoter region of the IL‐10 gene are associated with food allergy (FA) susceptibility in Caucasian pediatric patients with concomitant allergic diseases and IL‐10 levels.MethodsThe single nucleotide polymorphisms (SNPs) at ‐1082A > G (rs1800896), ‐819 T > C (rs1800871), and ‐592A > C (rs1800872) of 62 pediatric patients with IgE‐mediated FA were analyzed and correlated with clinical parameters, serum IgE and IL‐10 levels. The results were compared with those of 92 healthy controls without FA, personal and/or family history of atopy.ResultsAnalysis and comparison of genotype distributions, allele frequencies, and haplotypes showed that none of the genotypes confers an increased risk of FA. The genotype ‐1082 AA in FA patients was associated with moderate to severe symptoms of FA, the development of atopic asthma, and higher levels of IL‐10. In a linear regression study, we confirmed that the genotype ‐1082 AA acts as an independent factor for the higher levels of IL‐10. A positive association was also observed between ‐819T/C and ‐592 A/C SNPs and later onset of FA.ConclusionPolymorphisms in the promoter region of the IL‐10 gene are not associated with FA susceptibility in our cohort. In FA patients, ‐1082 A/G SNPs seem to influence the production of IL‐10, the severity of FA symptoms, and the development of atopic asthma in this population.
Preparedness for peer first response to mining emergencies resulting in injuries: a cross-sectional study
Authors: Karlsson Sofia , Saveman Britt-Inger , Hultin Magnus , Björnstig Ulf , Gyllencreutz Lina 
Published: November 2020

ObjectiveIdentify factors of preparedness for peer first response to underground mining emergencies with injured victims.DesignCross-sectional questionnaire study of Swedish underground mineworkers.SettingSeven out of nine Swedish underground mines.ParticipantsA total of 741 mineworkers out of 1022 (73%) participated in this study.InterventionsNone.Outcome measuresLevel of preparedness for emergencies with injuries in underground mines.ResultsThree factors influenced the preparedness of mineworkers for a peer first response: (1) familiarity with rescue procedures during emergencies with injuries; (2) risk perception of emergencies with injuries and (3) experience of using self-protective and first aid equipment. Mineworkers who believed that they knew how to handle emergencies with injuries (OR 1.30, 95% CI 1.22 to 1.38) and those who were trained in the use of self-protective and first aid equipment (OR 1.19, 95% CI 1.07 to 1.32) considered themselves to be better prepared for a peer first response than those who were unfamiliar with the rescue procedures or who had not used self-protective and first aid equipment. However, mineworkers who rated the risk for emergencies with injuries as high considered themselves to be less prepared than those who rated the risk as low (OR 0.95, 95% CI 0.91 to 0.98).ConclusionThis study identified three factors that were important for the peer-support preparedness of underground mineworkers. More research is needed to adapt and contextualise first aid courses to the needs of underground peer responders.
NTNU intranasal naloxone trial (NINA-1) study protocol for a double-blind, double-dummy, non-inferiority randomised controlled trial comparing intranasal 1.4 mg to intramuscular 0.8 mg naloxone for prehospital use
Authors: Skulberg Arne Kristian , Tylleskär Ida , Braarud Anne-Cathrine , Dale Jostein , Heyerdahl Fridtjof , Mellesmo Sindre , Valberg Morten , Dale Ola 
Published: November 2020

IntroductionIntranasal (IN) naloxone is widely used to treat opioid overdoses. The advantage of nasal administration compared with injection lies in its suitability for administration by lay people as it is needless. Approved formulations of nasal naloxone with bioavailability of approximately 50% have only undergone trials in healthy volunteers, while off-label nasal sprays with low bioavailability have been studied in patients. Randomised clinical trials are needed to investigate efficacy and safety of approved IN naloxone in patients suffering overdose. This study investigates whether the administration of 1.4 mg naloxone in 0.1 mL per dose is non-inferior to 0.8 mg intramuscular injection in patients treated for opioid overdose.Methods and analysisSponsor is the Norwegian University of Science and Technology. The study has been developed in collaboration with user representatives. The primary endpoint is the restoration of spontaneous respiration≥10 breaths/min based on a sample of 200 opioid overdose cases. Double-dummy design ensures blinding, which will be maintained until the database is locked.Ethics and disseminationThe study was approved by the Norwegian Medicines Agency and Regional Ethics Committees (REC: 2016/2000). It adheres to the Good Clinical Practice guidelines as set out by the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use.Informed consent will be sought through a differentiated model. This allows for deferred consent after inclusion for patients who have regained the ability to consent. Patients who are unable to consent prior to discharge by emergency services are given written information and can withdraw at a later date in line with user recommendations. Metadata will be published in the Norwegian University of Science and Technology Open repository. Deidentified individual participant data will be made available to recipients conditional of data processor agreement being entered.Trial registration numbersEudraCT Registry (2016-004072-22) and Clinicaltrials.gov Registry (NCT03518021).
What items should be included in an early warning score for remote assessment of suspected COVID-19? qualitative and Delphi study
Authors: Greenhalgh Trisha , Thompson Paul , Weiringa Sietse , Neves Ana Luisa , Husain Laiba , Dunlop Merlin , Rushforth Alexander , Nunan David , de Lusignan Simon , Delaney Brendan 
Published: November 2020

BackgroundTo develop items for an early warning score (RECAP: REmote COVID-19 Assessment in Primary Care) for patients with suspected COVID-19 who need escalation to next level of care.MethodsThe study was based in UK primary healthcare. The mixed-methods design included rapid review, Delphi panel, interviews, focus groups and software development. Participants were 112 primary care clinicians and 50 patients recovered from COVID-19, recruited through social media, patient groups and snowballing. Using rapid literature review, we identified signs and symptoms which are commoner in severe COVID-19. Building a preliminary set of items from these, we ran four rounds of an online Delphi panel with 72 clinicians, the last incorporating fictional vignettes, collating data on R software. We refined the items iteratively in response to quantitative and qualitative feedback. Items in the penultimate round were checked against narrative interviews with 50 COVID-19 patients. We required, for each item, at least 80% clinician agreement on relevance, wording and cut-off values, and that the item addressed issues and concerns raised by patients. In focus groups, 40 clinicians suggested further refinements and discussed workability of the instrument in relation to local resources and care pathways. This informed design of an electronic template for primary care systems.ResultsThe prevalidation RECAP-V0 comprises a red flag alert box and 10 assessment items: pulse, shortness of breath or respiratory rate, trajectory of breathlessness, pulse oximeter reading (with brief exercise test if appropriate) or symptoms suggestive of hypoxia, temperature or fever symptoms, duration of symptoms, muscle aches, new confusion, shielded list and known risk factors for poor outcome. It is not yet known how sensitive or specific it is.ConclusionsItems on RECAP-V0 align strongly with published evidence, clinical judgement and patient experience. The validation phase of this study is ongoing.Trial registration numberNCT04435041.
Systematic approach to selecting licensed drugs for repurposing in the treatment of progressive multiple sclerosis
Authors: Cunniffe Nick , Vuong Khue Anh , Ainslie Debbie , Baker David , Beveridge Judy , Bickley Sorrel , Camilleri Patrick , Craner Matthew , Fitzgerald Denise , de la Fuente Alerie G , Giovannoni Gavin , Gray Emma , Hazlehurst Lorraine , Kapoor Raj , Kaur Ranjit , Kozlowski David , Lumicisi Brooke , Mahad Don , Neumann Björn , Palmer Alan , Peruzzotti-Jametti Luca , Pluchino Stefano , Robertson Jennifer , Rothaul Alan , Shellard Lyndsey , Smith Kenneth J , Wilkins Alastair , Williams Anna , Coles Alasdair 
Published: November 2020

ObjectiveTo establish a rigorous, expert-led, evidence-based approach to the evaluation of licensed drugs for repurposing and testing in clinical trials of people with progressive multiple sclerosis (MS).MethodsWe long-listed licensed drugs with evidence of human safety, blood–brain barrier penetrance and demonstrable efficacy in at least one animal model, or mechanistic target, agreed by a panel of experts and people with MS to be relevant to the pathogenesis of progression. We systematically reviewed the preclinical and clinical literature for each compound, condensed this into a database of summary documents and short-listed drugs by scoring each one of them. Drugs were evaluated for immediate use in a clinical trial, and our selection was scrutinised by a final independent expert review.ResultsFrom a short list of 55 treatments, we recommended four treatments for immediate testing in progressive MS: R-α-lipoic acid, metformin, the combination treatment of R-α-lipoic acid and metformin, and niacin. We also prioritised clemastine, lamotrigine, oxcarbazepine, nimodipine and flunarizine.ConclusionsWe report a standardised approach for the identification of candidate drugs for repurposing in the treatment of progressive MS.
A generalized q growth model based on nonadditive entropy
Authors: Rondón Irving , Sotolongo-Costa Oscar , González Jorge A. , Lee Jooyoung 
Published: November 2020

We present a general growth model based on nonextensive statistical physics. We show that the most common unidimensional growth laws such as power law, exponential, logistic, Richards, Von Bertalanffy, Gompertz can be obtained. This model belongs to a particular case reported in (Physica A 369, 645 (2006)). The new evolution equation resembles the “universality” revealed by West for ontogenetic growth (Nature 413, 628 (2001)). We show that for early times the model follows a power law growth as [Formula: see text], where the exponent [Formula: see text] classifies different types of growth. Several examples are given and discussed.
Estrogen Receptor Alpha Mutations in Breast Cancer Cells Cause Gene Expression Changes through Constant Activity and Secondary Effects
Authors: Arnesen Spencer , Blanchard Zannel , Williams Michelle M. , Berrett Kristofer C. , Li Zheqi , Oesterreich Steffi , Richer Jennifer K. , Gertz Jason 
Published: November 2020

Abstract

While breast cancer patients with tumors that express estrogen receptor α (ER) generally respond well to hormone therapies that block ER activity, a significant number of patients relapse. Approximately 30% of these recurrences harbor activating mutations in the ligand binding domain (LBD) of ER, which have been shown to confer ligand-independent function. However, much is still unclear regarding the effect of mutant ER beyond its estrogen independence. To investigate the molecular effects of mutant ER, we developed multiple isogenic ER-mutant cell lines for the most common LBD mutations, Y537S and D538G. These mutations induced differential expression of thousands of genes, the majority of which were mutant allele specific and were not observed upon estrogen treatment of wild-type (WT) cells. These mutant-specific genes showed consistent differential expression across ER-mutant lines developed in other laboratories. WT cells with long-term estrogen exposure only exhibited some of these transcriptional changes, suggesting that mutant ER causes novel regulatory effects that are not simply due to constant activity. While ER mutations exhibited minor effects on ER genomic binding, with the exception of ligand independence, ER mutations conferred substantial differences in chromatin accessibility. Mutant ER was bound to approximately a quarter of mutant-enriched accessible regions that were enriched for other DNA binding factors, including FOXA1, CTCF, and OCT1. Overall, our findings indicate that mutant ER causes several consistent effects on gene expression, both indirectly and through constant activity.

Significance:
This study demonstrates the multiple roles of mutant ER in breast cancer progression, including constant ER activity and secondary regulatory effects on gene expression and chromatin accessibility.
Corpo e espaço: uma reflexão dialética acerca do objeto de estudo da geografia
Authors: Bragioni Guido Lins Lopes , Araújo Marina 
Published: November 2020

Este ensaio se propõe a refletir, através da arte, sobreo conceito de espaço e suas relações dialéticas com a paisagem, o território, o lugar e o corpo. Neste sentido, pensar as relações entre a Geografia e o corpo significa conceber que o espaço geográfico é constituído por uma materialidade animada, misturada e marcada nos corpos e, ao mesmo tempo, que esses corpos se aportam no espaço e no tempo, atravessados pelas intensidades com as quais experimentam o mundo.

PALAVRAS-CHAVE: Espaço; Paisagem; Território; Lugar, Corpo.
Nonconserved Long Intergenic Noncoding RNAs Associate With Complex Cardiometabolic Disease Traits
Authors: Foulkes Andrea S. , Selvaggi Caitlin , Cao Tingyi , O’Reilly Marcella E. , Cynn Esther , Ma Puyang , Lumish Heidi , Xue Chenyi , Reilly Muredach P. 
Published: November 2020

Objective:
Transcriptome profiling of human tissues has revealed thousands of long intergenic noncoding RNAs (lincRNAs) at loci identified through large-scale genome-wide studies for complex cardiometabolic traits. This raises the question of whether genetic variation at nonconserved lincRNAs has any systematic association with complex disease, and if so, how different this pattern is from conserved lincRNAs. We evaluated whether the associations between nonconserved lincRNAs and 8 complex cardiometabolic traits resemble or differ from the pattern of association for conserved lincRNAs.

Approach and Results:
Our investigation of over 7000 lincRNA annotations from GENCODE Release 33–GRCh38.p13 for complex trait genetic associations leveraged several large, established meta-analyses genome-wide association study summary data resources, including GIANT (Genetic Investigation of Anthropometric Traits), UK Biobank, GLGC (Global Lipids Genetics Consortium), Cardiogram (Coronary Artery Disease Genome Wide Replication and Meta-Analysis), and DIAGRAM (Diabetes Genetics Replication and Meta-Analysis)/DIAMANTE (Diabetes Meta-Analysis of Trans-Ethnic Association Studies). These analyses revealed that (1) nonconserved lincRNAs associate with a range of cardiometabolic traits at a rate that is generally consistent with conserved lincRNAs; (2) these findings persist across different definitions of conservation; and (3) overall across all cardiometabolic traits, approximately one-third of genome-wide association study–associated lincRNAs are nonconserved, and this increases to about two-thirds using a more stringent definition of conservation.

Conclusions:
These findings suggest that the traditional notion of conservation driving prioritization for functional and translational follow-up of complex cardiometabolic genomic discoveries may need to be revised in the context of the abundance of nonconserved long noncoding RNAs in the human genome and their apparent predilection to associate with complex cardiometabolic traits.
Pragmatism and Jewish Thought: Eliezer Berkovits’s Philosophy of Halakhic Fallibility
Authors: Berman Shifman Nadav 
Published: November 2020

Abstract
In classical American pragmatism, fallibilism refers to the conception of truth as an ongoing process of improving human knowledge that is nevertheless susceptible to error. This paper traces appearances of fallibilism in Jewish thought in general, and particularly in the halakhic thought of Eliezer Berkovits. Berkovits recognizes the human condition’s persistent mutability, which he sees as characterizing the ongoing effort to interpret and apply halakhah in shifting historical and social contexts as Torat Ḥayyim. In the conclusion of the article, broader questions and observations are raised regarding Jewish tradition, fallibility, and modernity, and the interaction between Judaism and pragmatism in the history of ideas.
Trans-Tasman Resources Limited v. Taranaki-Whanganui Conservation Board
Authors: Makgill Robert A. , Gardner-Hopkins James D. , Coates Natalie R. 
Published: November 2020

Abstract
On 3 April 2020, the Court of Appeal delivered a judgment quashing a decision to approve a seabed mining proposal within New Zealand’s exclusive economic zone (EEZ). This article discusses the judgment’s background, its references to the law of the sea and other international law, and the Court of Appeal’s four key findings. These findings include that the seabed mining approval: (a) failed to ensure protection of the marine environment from pollution; (b) failed to favour caution and protection where information is uncertain or inadequate; (c) failed to integrate decision-making between the EEZ and territorial sea; and (d) failed to adopt an approach to effects consistent with indigenous rights. The article concludes with some observations on the judgment’s relevance to State practice and seabed mining under international law.
Politics of Culture and Cosmopolitan Nostalgia during Islamists’ Rule in Egypt
Authors: Mustonen Liina 
Published: November 2020

Abstract
In the aftermath of the Egyptian uprising in 2011 when Egypt witnessed the emergence of a new Islamist political elite, nostalgia for the country’s glorified past took on an increased political value for those who opposed the new rulers. A Cairo-based milieu of socioeconomically privileged actors, who anxiously observed the election victories of the Muslim Brotherhood, criticized the political developments in light of an imagined Egyptian past. In this article I analyze their discourses and practices and show how they instrumentalized notions of an ancient Egyptian civilization and Egypt’s imagined cosmopolitan past in their critique of the new rulers. It illustrates how, in the political climate of growing tensions after the election of Muhammad Morsi, references to an imagined past, one that was more tolerant, civilized and cosmopolitan, provided a critical resource for those who opposed the new rulers. In the article I locate these propagated visions of cosmopolitanism in the context of Egyptian nationalism and the grand narrative of the Egyptian state.
Poetics or Homiletics? Hearing and Feeling the New Testament in Erasmus’ Paraphrases
Authors: Leushuis Reinier 
Published: November 2020

Abstract
One of the unique homiletic challenges of the Erasmian paraphrase is the transmission of faith in divine matters from the page to the reader’s mind. By which form of imitation is the acquisition of faith by the disciples and their communities not only cognitively understood by, but also imitated in the reader’s mind? Constituting what can be called a poetics of Erasmus’ paraphrastic writing, questions of literary imitation and transmission are exemplified in his enrichment of the sensorial and emotional aspects of the biblical narrative. This essay examines instances where the biblical text highlights the disciples’ witnessing of Jesus both in earthly life and as a risen but living presence. Such instances lead to paraphrastic developments that exemplify reader-oriented imitation by instrumentalizing the senses, in particular hearing and touch, to steer the reader’s inner affective response, and thus to facilitate the acquisition of faith. Although sight is not neglected, I argue that in this process hearing and feeling (both as touch and emotion) are poetically and homiletically privileged to lodge the holy Word in the innermost affective sanctuary of a community of readers and listeners over time who, unlike the witnessing disciples, can no longer see, hear, and touch Christ.
The Local Turn and the Framing of unoci’s Mandated Activities by the UN
Authors: Gilder Alexander 
Published: November 2020

Abstract
This article engages specifically with the local turn in UN peace operations by looking at local engagement and empowerment in the UN Operation in Côte d’Ivoire. After the closure of a long-serving UN peace operation it is important to take stock of the activities pursued under the mandate and reflect on how the mission has contributed to peacekeeping practice. UN peace operations have increasingly undertaken peacebuilding activities at the local level with current literature emphasising the need to involve local actors in decision-making and reconciliation activities. In seeking to uncover how the UN understands the need to involve local actors, the mission activities of unoci are broken down into a number of themes looking at how the local are engaged, given agency and empowered, and also where the UN recognises specific vulnerabilities of persons. The article shows how the UN portrays its activities and where it has either expressly or impliedly sought to demonstrate a concern for the local in Côte d’Ivoire.