bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of lncRNA LINC00520 and functional polymorphisms associated with breast cancer susceptibility in Chinese Han population
Authors: Guo Qiaoyun , Xu Linping , Peng Rui , Ma Yan , Wang Yanli , Chong Feifei , Song Mengmeng , Dai Liping , Song Chunhua 
Published: January 2020

AbstractBackgroundThe aim was to evaluate the association between the LINC00520 genetic polymorphisms and breast cancer (BC) susceptibility.MethodsNine single‐nucleotide polymorphisms (SNPs) on LINC00520 genotyping were performed in 504 BC patients and 505 cancer‐free controls in Chinese Han population to study the relationship between LINC00520 polymorphism and BC susceptibility. qRT‐PCR and luciferase tests were used to explore how rs12880540 affected the expression of LINC00520.ResultsThe genotype GG (OR:3.58, 95%CI:1.32‐9.69) in rs8012083 increased the risk of triple‐negative BC. The genotype GG (OR:0.31, 95%CI:0.14‐0.69) in rs8012083, the genotype AA (OR:2.74, 95%CI:1.01‐7.42) in rs2152275, and genotype TG (OR:1.62, 95%CI:1.04‐2.52) in rs12880540 were associated with HER‐2 status. The dominant (OR:0.65, 95%CI:0.45‐0.95) and overdominant genetic model (OR:0.67, 95%CI:0.46‐0.98) consistently showed that rs11622641 T was significantly associated with lower risk of BC. Similarly, the recessive genetic model (OR:1.57, 95%CI:1.07‐2.30) of rs12880540 and the dominant (OR:1.62, 95%CI:1.24‐2.11) and overdominant (OR:1.56, 95%CI:1.19‐2.03) genetic model of rs2152278 may increase the risk of BC. The relative expression of LINC00520 increased linearly with the increase in the number of rs12880540 mutations. rs12880540 alleles were due to the interaction between LINC00520 and miR‐3122 at T, but the mutation of rs12880540 G > T had no effect on the binding ability of LINC00520 and miR‐3122.ConclusionA genetic variant of rs8012083 in LINC00520 may be used as a biomarker for triple‐negative BC after further evaluation of diagnostic tests. The genetic variant of LINC00520 was related to the susceptibility of BC, and rs12880540 might affect the corresponding mRNA expression of lncRNA LINC00520.
Long‐term outcome after deferred revascularization due to negative fractional flow reserve in intermediate coronary lesions
Authors: Weerts Jerremy , Pustjens Tobias , Amin Elsa , Ilhan Mustafa , Veenstra Leo F. , Theunissen Ralph A. L. J. , Vainer Jindrich , Stein Mera , Ruiters Lex A. W. , Gho Ben C. G. , Van't Hof Arnoud W. J. , Rasoul Saman 
Published: January 2020

AbstractObjectivesThe aim was to assess long‐term outcome after deferring intervention of coronary lesions with a fractional flow reserve (FFR) value of >0.80 in a real‐world patient population and then to identify factors associated with deferred target lesion failure (DTLF).BackgroundDeferring coronary interventions of intermediate lesions based on FFR measurement is safe, irrespective of the extent of coronary artery disease. However, FFR values near the cut‐off of >0.80 may have less favorable outcome.MethodsA retrospective analysis was performed in patients with deferred coronary intervention based on FFR value >0.80. The primary endpoint was DTLF, a composite of acute coronary syndrome (ACS) and any coronary revascularization, related to the initially deferred stenosis.ResultsA total of 600 patients, mean age of 66 ± 10 years, and 751 coronary lesions with negative FFR values (mean 0.88 ± 0.04) were included. The mean follow‐up was 27 ± 15 months. DTLF occurred in 44 patients (7.3%), revascularization in 42 (7%), and ACS without revascularization in 2 patients (0.3%). Patients with DTLF more often had diabetes mellitus, previous coronary artery bypass grafting, multivessel disease (MVD), and lower FFR at inclusion. Multivariable regression analysis showed that lower deferred FFR values [FFR 0.81–0.85: hazard ratio (HR) 2.79 (95% CI [confidence interval]; 1.46–5.32), p .002], MVD [HR 1.98 (95% CI; 1.05–3.75), p .036], distal lesions [HR 2.43 (95% CI; 1.29–4.57), p .006], and lesions located in a saphenous vein graft (SVG) [HR 6.35 (95% CI; 1.81–22.28), p .004] were independent predictors for DTLF.ConclusionsThe long‐term rate of DTLF of initially deferred coronary lesions was 7.3%. Independent predictors for DTLF are lower deferred FFR value, the presence of MVD, distal lesions, and lesions in SVG.
Should kyphoplasty curettes be used in nonosteoporotic patients? A cautionary tale
Authors: Mattei Tobias A. , Perret Caio M. 
Published: January 2020

AbstractThe authors present the first report of a fracture of the tip of a kyphoplasty curette inside the vertebral body, which occurred during a procedure in a patient with non‐osteoporotic fracture. This highlights the need of further biomechanical research focused on the shear load failure properties of such type of pre‐bent curettes
Reel syndrome—An uncommon etiology of ICD dysfunction
Authors: Bazoukis George , Kollias George , Tse Gary , Saplaouras Athanasios , Mililis Panagiotis , Sakellaropoulou Antigoni , Kolokathis Angelos‐Michail , Asvestas Dimitrios , Efremidis Michael , Sideris Antonios , Letsas Konstantinos P. 
Published: January 2020

AbstractReel syndrome occurs due to the rotation of the implantable device on its transverse axis with subsequent coiling of the leads around the pulse generator. Device interrogation and chest X‐ray should be performed in any case of device malfunction.
Metal‐Terpyridine Complexes in Catalytic Application – A Spotlight on the Last Decade
Authors: Winter Andreas , Schubert Ulrich S. 
Published: January 2020

Abstract2,2′:6′,2′′‐Terpyridine (tpy) and its derivatives represent highly versatile ligands for the complexation of transition metal ions. Today, such complexes are employed in a highly diverse fashion – includinginter aliamaterials science, opto‐electronics, pharmacy or catalysis. Concerning the latter one, a vast development has led to new or improved applications in both “conventional” organic chemistry (i. e., catalysis of functional‐group interconversions, CH‐activation or cross‐coupling reactions) as well as energy‐related applications (e. g., CO2reduction, artificial photosynthesis, dye degradation). In this respect, not only homogeneous catalysts (i. e., molecular complexes) but also heterogeneous and recyclable ones have moved to the focus of interest. These heterogeneous structures include 1D metallopolymers, metal‐organic frameworks (MOFs), organic‐inorganic hybrids and bio‐inspired catalysts. We gave a first overview on this topic already in 2011; in here, the methods and implementations established within the last decade as well as relevant contributions from earlier works are presented and discussed.
Modeling of Ethylene Glycol Production from Glucose in a Semi‐Continuous Reactor
Authors: Murillo Carlos , Irakoze Ghislain , de Oliveira Vigier Karine , Delmas Michel , Jérôme François , Pérès Yolande , Urrutigoity Martine , Cognet Patrick 
Published: January 2020

AbstractA numerical study describes the catalytic conversion of glucose into ethylene glycol (EG) in a semi‐batch reactor. This analysis couples a set of power law models (homogeneous reactions) and Langmuir‐Hinshelwood‐Hougen‐Watson (LHHW) equations (hydrogenations). For this purpose, the kinetic parameters of the LHHW expressions are estimated for the reaction conditions. Then, the kinetic model evaluates the influence of the H2 pressure and the catalyst concentrations on the selectivity. The results indicate that the EG yield is increased by setting the temperature and the H2 pressure. In this manner, the process reduces the hexitols and methane production and increases the EG yield. The originality of the work is based on the influence of the H2 pressure and the catalyst concentrations in the model.
Sulfuryl Fluoride Mediated Synthesis of Amides and Amidines from Ketoximes via Beckmann Rearrangement
Authors: Gurjar Jitendra , Fokin Valery V. 
Published: January 2020

AbstractA metal‐free and redox‐neutral method for Beckmann rearrangement employing inexpensive and readily available SO2F2 gas is described. The reported transformation proceeds at ambient temperature and is compatible with a wide range of sterically and electronically diverse aromatic, heteroaromatic, aliphatic and lignin‐like oximes providing amides in good to excellent yields. The reaction proceeds through the formation of an imidoyl fluoride intermediate that can also be used for the synthesis of amidines.
Parallel Versus Antiparallel β‐Sheet Structure in Cyclic Peptide Hybrids Containing γ‐ or δ‐Cyclic Amino Acids
Authors: Calvelo Martín , Lamas Alejandro , Guerra Arcadio , Amorín Manuel , Garcia‐Fandino Rebeca , Granja Juan R. 
Published: January 2020

AbstractCyclic peptides with disc‐shaped structures have emerged as potent building blocks for the preparation of new biomaterials in fields ranging from biological to material science. In this work, we analyze in depth the self‐assembling properties of a new type of cyclic peptides based on the alternation of α‐residues and cyclic δ‐amino acids (α,δ‐CPs). To examine the preferred stacking properties adopted by cyclic peptides bearing this type of amino acids, we carried out a synergistic in vitro/in silico approximation by using simple dimeric models and then extended to nanotubes. Although these new cyclic peptides (α,δ‐CPs) can interact either in a parallel or antiparallel fashion, our results confirm that although the parallel β‐sheet is more stable, it can be switched to the antiparallel stacking by choosing residues that can establish favorable cross‐strand interactions. Moreover, the subsequent comparison by using the same methodology but applied to α,γ‐CPs models, up to the moment assumed as antiparallel‐like d,l‐α‐CPs, led to unforeseen conclusions that put into question preliminary conjectures about these systems. Surprisingly, they tend to adopt a parallel β‐sheet directed by the skeleton interactions. These results imply a change of paradigm with respect to cyclic peptide designs that should be considered for dimers and nanotubes.
BODIPYs as Chemically Stable Fluorescent Tags for Synthetic Glycosylation Strategies towards Fluorescently Labeled Saccharides
Authors: Uriel Clara , Permingeat Caterina , Ventura Juan , Avellanal‐Zaballa Edurne , Bañuelos Jorge , García‐Moreno Inmaculada , Gómez Ana M. , Lopez J. Cristobal 
Published: January 2020

AbstractA series of fluorescent boron‐dipyrromethene (BODIPY, 4,4‐difluoro‐4‐bora‐3a,4a‐diaza‐s‐indacene) dyes have been designed to participate, as aglycons, in synthetic oligosaccharide protocols. As such, they served a dual purpose: first, by being incorporated at the beginning of the process (at the reducing‐end of the growing saccharide moiety), they can function as fluorescent glycosyl tags, facilitating the detection and purification of the desired glycosidic intermediates, and secondly, the presence of these chromophores on the ensuing compounds grants access to fluorescently labeled saccharides. In this context, a sought‐after feature of the fluorescent dyes has been their chemical robustness. Accordingly, some BODIPY derivatives described in this work can withstand the reaction conditions commonly employed in the chemical synthesis of saccharides; namely, glycosylation and protecting‐group manipulations. Regarding their photophysical properties, the BODIPY‐labeled saccharides obtained in this work display remarkable fluorescence efficiency in water, reaching quantum yield values up to 82 %, as well as notable lasing efficiencies and photostabilities.
Two Push–Pull Channels Enhance the Dinitrogen Activation by Borylene Compounds
Authors: Zhang Huaiyu , Yuan Rui , Wu Wei , Mo Yirong 
Published: January 2020

AbstractBorylenes can bind and activate N2. In the end‐on bridging borylene–N2 complexes, the π orbitals of N2 dominate the σ donation to one of the borylenes whereas the perpendicular π* anti‐bonding orbitals of N2 can accept back‐donations from another borylene. Thus, there are two opposite and perpendicular push–pull channels which govern the activation of N2 and the BNNB bent geometry. More information can be found in the Full Paper by Y. Mo, et al. on page 2619. Invited for the cover of this issue is Huaiyu Zhang and co‐workers. The image depicts the push–pull channels in dinitrogen activation by two borylenes. Read the full text of the article at 10.1002/chem.201904724.
Untapped Opportunities of Resin‐to‐Resin Transfer Reactions (RRTR) for the Convergent Assembly of Multivalent Peptide Conjugates
Authors: Verzele Dieter , Ruiz García Yara , Madder Annemieke 
Published: January 2020

AbstractHandling of the individual fragments remains a bottleneck in the convergent assembly of peptides. Overlooked since the emergence of ligation chemistries during the past two decades, so‐called resin‐to‐resin transfer reactions (RRTR) are here described as a strategic shortcut in this context. Condensation of the involved moieties at an acceptor resin is facilitated by shuttling peptide segments directly from a donor resin in a one‐pot fashion. The straightforward synthesis of a sterically constrained 13‐mer peptidosteroid model illustrates the utility of this approach, presenting the first successful application of the RRTR methodology in the field of multivalent design and bioconjugation. Relying on established procedures to generate, monitor and isolate intermediates and products, the solid‐phase nature of the entire strategy allows for the fast construction of polypeptide adducts and libraries thereof. As such, a rejuvenated use and new opportunities for RRTR are reported.
Funktionalisierte Kern‐Schale‐Partikel als Träger zur Enzymimmobilisierung und deren Anwendung
Authors: Matura Anke , Köpke Dorina , Marschelke Claudia , Kramer Julius , Synytska Alla , Sallat Marco 
Published: January 2020

AbstractMono‐ und bifunktionale hybride Kern‐Schale‐Partikel wurden für die Enzymimmobilisierung eingesetzt. An monofunktionalen Poly(2‐dimethylamino)ethylmethacrylat‐modifizierten Partikeln wurden die idealen Bedingungen für die Immobilisierung untersucht. Anschließend erfolgte die Übertragung auf bifunktionale Janus‐Partikel‐Systeme, mit denen gleichzeitig die schaltbare Abtrennung und der erneute Einsatz der Enzyme möglich waren. Abschließend wurde der mehrfache Einsatz der enzymbeladenen Partikel modellhaft am Beispiel der Prozesswasserentfärbung aus der Textilindustrie mit Laccase gezeigt und eine Kostenrechnung durchgeführt.
Overcoming acquired resistance of epidermal growth factor receptor‐mutant non–small cell lung cancer cells to osimertinib by combining osimertinib with the histone deacetylase inhibitor panobinostat (LBH589)
Authors: Zang Hongjing , Qian Guoqing , Zong Dan , Fan Songqing , Owonikoko Taofeek K. , Ramalingam Suresh S. , Sun Shi‐Yong 
Published: January 2020

BackgroundThe major clinical obstacle that limits the long‐term benefits of treatment with osimertinib (AZD9291) in patients with epidermal growth factor receptor‐mutant non–small cell lung cancer is the development of acquired resistance. Therefore, effective strategies that can overcome acquired resistance to osimertinib are urgently needed. The authors' current efforts in this direction have identified LBH589 (panobinostat), a clinically used histone deacetylase inhibitor, as a potential agent in overcoming osimertinib resistance.MethodsCell growth and apoptosis in vitro were evaluated by measuring cell numbers and colony formation and by detecting annexin V‐positive cells and protein cleavage, respectively. Drug effects on tumor growth in vivo were assessed with xenografts in nude mice. Alterations of tested proteins in cells were monitored with Western blot analysis. Gene knockout was achieved using the CRISPR/Cas9 technique.ResultsThe combination of LBH589 and osimertinib synergistically decreased the survival of different osimertinib‐resistant cell lines, including those harboring C797S mutations, with greater inhibition of cell colony formation and growth. The combination enhanced the induction of apoptosis in osimertinib‐resistant cells. Importantly, the combination effectively inhibited the growth of osimertinib‐resistant xenograft tumors in nude mice. Mechanistically, the combination of LBH589 and osimertinib enhanced the elevation of Bim in osimertinib‐resistant cells. Knockout of Bim in osimertinib‐resistant cells substantially attenuated or abolished apoptosis enhanced by the LBH589 and osimertinib combination. These results collectively support a critical role of Bim elevation in the induction of apoptosis of osimertinib‐resistant cells for this combination.ConclusionsThe current findings provide strong preclinical evidence in support of the potential for LBH589 to overcome osimertinib resistance in the clinic.
Sunflower evapotranspiration and water use efficiency in response to plant density
Authors: Echarte L. , Echarte M.M. , Cerrudo D. , Gonzalez V.H. , Alfonso C. , Cambareri M. , Hernandez M.D. , Nagore M.L. , Maggiora A. Della 
Published: January 2020

AbstractThis study quantified sunflower (Helianthus annuus L.) water use efficiency for seed (WUEg) and for oil yield (WUEo) and their components (i.e., evapotranspiration [ET], seed and oil yields) in response to plant density increments and studied, in particular, the underlying processes relevant to the responses of crop ET to plant density (i.e. water uptake pattern, intercepted photosynthetically active radiation [iPAR], and soil water depletion profile). Sunflower was grown at 3, 6, and 9 plants m−2 in Season 1 and at 2, 3 and 6 plants m−2 in Season 2. Measurements included (i) soil water content and iPAR during the whole growing season, and (ii) seed and oil yield at physiological maturity. Crop ET was estimated by means of a water balance, and it was analyzed during three different periods (i.e. vegetative, critical period for seed set, and seed filling period). Increasing sunflower plant density from 2 to 9 plants m−2 did not modify seasonal ET, but it changed the water uptake pattern through the season; it increased ET during the vegetative period by depleting more water from deep soil layers (i.e., 41–140 cm), but it reduced ET during the seed‐filling period. Increments in plant density increased seed and oil yield in accordance with significant iPAR increments, whereas harvest index remained stable. Sunflower WUEg ranged from 4.8 to 9.4 kg ha−1 mm−1, WUEo ranged from 1.8 to 4.5 kg oil ha−1 mm−1 across plant densities, and they were positively and closely associated with seasonal iPAR.
Hydrogel–Polymer Electrolyte for Electrochemical Capacitors with High Volumetric Energy and Life Span
Authors: Gajewski Piotr , Béguin Francois 
Published: January 2020

AbstractAC/AC (AC=activated carbon) electrochemical capacitors (ECs) were designed with a 1 mol L−1 lithium sulfate hydrogel– polymer electrolyte (HPE) based on carboxymethyl cellulose sodium salt (CMC). The electrochemical performance of the ECs was compared with that of cells composed of common separators such as a polyolefin membrane (Celgard 3501, polypropylene separator coated by surfactant) and a glass microfiber membrane (Whatman GF/A). The ECs with Celgard 3501 and home‐made CMC‐HPE demonstrated a higher volumetric energy than that with Whatman GF/A. However, after 120 h of floating at 1.5 V, the capacitance of the EC with Celgard 3501 decreased dramatically by 25 %, whereas with CMC‐HPE and Whatman GF/A, the decrease was only 4 and 6 %, respectively. Post‐mortem observations of the Celgard 3501 separator after floating suggested that the surfactant layer was removed, which caused a decrease of separator wettability, as confirmed by the slow evolution of the electrolyte contact angle on its surface. Hence, CMC‐HPE is a very attractive option to develop aqueous‐electrolyte‐based ECs with an excellent life span and high volumetric energy density.
New generalized topologies of asymmetric modular multilevel inverter based on six‐switch H‐bridge
Authors: Ghodsi Masoud , Barakati S. Masoud 
Published: January 2020

SummaryIn this paper, for high and low numbers of voltage levels, two new generalized multilevel converters are introduced, which comprise a six‐switch H‐bridge and several switched‐source units. Switched‐source units consist of bidirectional and unidirectional switches along with a dc voltage source. The two proposed topologies are compared with topologies based on the six‐switch H‐bridge, conventional H‐bridge, and some new topologies regarding the number of switches, dc voltage sources, gate drivers, and per‐unit voltage block on switches. The comparison results reveal the superiority of the proposed topology with low number of voltage level (LNL) and proposed topology with high number of voltage level (HNL) regarding the per‐unit voltage block and number of elements, respectively. Thus, the proposed topologies lead to reduction cost and weight of system. Furthermore, for high number of levels, HNL topology is more appropriate than LNL topology and vice versa. The performances of the proposed 15‐level LNL and 61‐level topologies are simulated by MATLAB, and proposed 15‐level LNL topology in producing all voltage levels is validated by experimental results.
Time‐dependent plasma transport simulation for the study of edge impurity radiation dynamics with magnetic island in large helical device
Authors: Kobayashi Masahiro , Tokar Mikhail Z. 
Published: January 2020

AbstractThe dynamics of impurity radiation distribution during detachment transition with edge magnetic island induced by the application of resonant magnetic perturbation (RMP) is studied numerically by solving time‐dependent plasma fluid equations together with impurity and neutral transports in a 2D grid system. Computations provide the appearance of a macroscopic structure in the heat transfer along the island separatrix and outside the island. The resultant parallel temperature gradient generates the plasma flow and the density gradient according to the parallel momentum balance. The resulting plasma flow effectively transports impurity towards the X‐point region. As a result, the impurity radiation is more intense near the X‐point than in the vicinity of the O‐point. This leads to the predominant cooling of the region around the X‐point. These results are in agreement with experimental observation with RMP application in the large helical device (LHD). The time scale of the thermal condensation instability is found to be of the order of 10 ms.
Exploiting WiMAX for covert transmission of secret data over fading channel
Authors: Kumar Sanjeev , Kumar Manoj , Singh Amarpal 
Published: January 2020

SummaryWorldwide Interoperability for Microwave Access (WiMAX) is the broadband wireless access technique that provides rapid broadband services to domestic and enterprise users. Owing to the broadcast characteristic of the WiMAX system, transmitted data security is crucial, particularly when the messages are confidential. In this work, exploiting of WiMAX to convey sensitive secret information is presented. In the first phase, we exploited conventional WiMAX (fast Fourier transform [FFT]‐WiMAX), and in the second phase, we propose a wavelet packet transform (WPT)–based WiMAX for covert communication. The quality evaluation of both covert transmission models (FFT‐WiMAX and WPT‐WiMAX) over the fading channel is done in this work. The experimental outcomes of the proposed WPT‐WiMAX covert transmission system reveal a significant enhancement in error rate (bit error rate) and peak signal‐to‐noise ratio for a given signal‐to‐noise ratio.