bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of disease-modifying antirheumatic drug therapy on immune response to trivalent influenza vaccine in rheumatoid arthritis
Authors: Jain Vikramraj K. , Bhashini Nandhini , Balajee L. Karthik , Sistla Sujatha , Parija Subhash Chandra , Negi Vir Singh 
Published: December 2024

Background & objectives:
Patients with autoimmune rheumatic diseases may be at an increased risk of infection due to disease and use of disease-modifying antirheumatic drug (DMARD) therapy. The present study was done to evaluate the immune response to influenza vaccination in patients with rheumatoid arthritis (RA).

Methods:
Fifty one RA patients on stable methotrexate (MTX) therapy (≥15 mg/wk), 51 newly diagnosed DMARD-naïve RA patients and 45 healthy controls received a single dose of inactivated seasonal trivalent influenza vaccine. Blood samples were collected just prior to and four weeks after vaccination. Pre- and post-vaccination antibody titres against the three virus strains were measured by hemagglutination inhibition assay. The impact of age, gender, DMARD treatment and pre-vaccination seroprotection on response to the vaccine was assessed by binary logistic regression analysis for each of the virus strains.

Results:
Pre-vaccination antibody titres were found to be high in the three study groups for all influenza strains, except for Yamagata strain, the titres for which were low in healthy controls. Trivalent influenza vaccination was found to be safe and stimulated a good antibody response in all study groups. On regression analysis, there was no association of age, gender or MTX therapy with vaccine response, except for Yamagata strain where healthy controls had higher positive immune response (P=0.008; odds ratio – 3.37, 95% confidence interval: 1.36-8.32).

Interpretation & conclusions:
Our results indicated that influenza vaccination was safe in RA patients with no detrimental effect on disease activity. MTX therapy at a dose ≥15 mg/wk did not affect the vaccine response. Presence of high pre-vaccination seroprotective antibody levels in the study population indicates the need for re-examination of recommended annual influenza vaccination in such subgroups of population.
Guillain–Barre syndrome
Authors: Shrivastava Manisha , Nehal Shah , Seema Navaid 
Published: December 2024

Background & objectives:
Guillain–Barre syndrome (GBS) is an autoimmune disease and a recognized cause of generalized progressive paralysis worldwide. The present study was aimed to document the clinical findings, demographics and seasonal variations amongst the patients with GBS during the hospital stay.

Methods:
A retrospective analysis of 66 referred cases diagnosed as GBS was conducted. Medical records and the data related to age, sex, antecedent illness, duration of symptoms before admission, muscle power graded by the Medical Research Council scale, functional scores, details of Intensive Care Unit complications and need for ventilation were obtained. The patients were divided into four seasonal groups: S1 (spring, February to April), S2 (summer, May to July), S3 (rainy, August to October) and S4 (winter, November to January) and parameters were studied.

Results:
The mean age of the patients was 40.69 yr. Forty one (62.1%) patients had a history of preceding illness. Forty nine (74.2%) patients showed quadriparesis as most common complaint. Thirty three (50%) patients were of acute inflammatory demyelinating polyneuropathy (AIDP) variant. The highest number of GBS cases (60%) was found in S1 and S2. The maximum duration of hospital stay was observed in S3 group (mean 23 days).

Interpretation & conclusions:
GBS seems to affect all age groups with male preponderance. Most common antecedent event and presenting feature were flu-like illness and quadriparesis, respectively. AIDP was the most common variant. Most cases occurred from February to July (S1 and S2 group) (maximum in July) with preceding influenza and diarrhoea and maximum duration of hospital stay was observed in S3 group. Prospective studies with follow up of GBS patients need to be done to confirm findings.
Static Foot Disorders as a Risk Factor for the Development of Chronic Venous Disease: A Cross-sectional, Single-center Study
Authors: Soti Nischal , Luitel Prajjwol , Paudel Sujan , Thapaliya Ishwor , Gorsi Ujjwal , Savlania Ajay 
Published: December 2024

Abstract

Introduction:
Static foot disorders (SFDs) are prevalent among adults and have been linked to chronic venous disease (CVD). This study aimed to investigate the prevalence of SFDs in patients with CVD and their association with disease severity.

Methodology:
This study was performed at the Department of General Surgery, Postgraduate Institute of Medical Education and Research to study the relationship between the SFDs and clinical, etiological, anatomical, and pathological elements (CEAP) clinical severity in the Indian population. A complete CEAP classification and venous symptoms were noted. Djian’s angle was used to quantify SFD.

Results:
Among the 224 feet examined, 50.4% had SFD (14.73% had hollow feet and 35.7% had flat feet), and 56.7% had advanced CVD (C3–6 group). There was no difference in SFD and CEAP class based on the laterality of the foot. Patients with advanced CVD (C3–C6) had a significantly higher incidence of SFDs compared to those with less severe disease (C0–C2), particularly among individuals aged <30 years (P < 0.05).

Conclusion:
This study underscores the high prevalence of SFDs in patients with CVD, especially among younger individuals with advanced disease. Search for SFD should be made during the examination of CVD. Further research is warranted to explore whether correction of SFD improves CVD symptoms.
Satisfaction amongst parents/guardians of children with cleft lip after repair at komfo anokye teaching hospital
Authors: S Obiri-Yeboah , D.O Addai , R.N.L Larmie , A Oti Acheampong , J.T Olesu , R Atuwo-Ampoh , P Frimpong , N.T Gyimah 
Published: December 2024

BACKGROUND: Orofacial clefts are a group of congenital deformities commonly presenting as cleft lip with or without cleft palate or solitary cleft palate. Cleft lip and palate (CL/P) is one of the world’s most frequent congenital birth abnormalities. It is estimated that 400 babies are born with orofacial cleft in Ghana every year.AIM: This study aimed to assess the level of satisfaction amongst parents/guardians of children who underwent cleft lip repair at Komfo Anokye Teaching Hospital (KATH) and the effect of cleft lip repair on their psychosocial status.MATERIALS AND METHODS: A cross-sectional survey was conducted, and data were collected from 73 parents/guardians of children who underwent cleft lip repair at KATH. The survey assessed parental satisfaction with the aesthetic outcome, the impact of the procedure on social interactions and family dynamics, and the overall psychosocial effect of cleft lip repair using the modified Cleft Evaluation Profile. The data was captured in Excel and analysed with the Statistical Package for the Social Sciences (SPSS) version 25.0.RESULTS: The majority of parents/guardians expressed overall satisfaction with the outcomes of cleft lip repair, with 67.1% reporting that the appearance of the lip was “Very satisfactory.” However, there were concerns regarding other facial features, such as teeth (21.9% unsatisfactory) and the face profile (35.6% very satisfactory). Despite these concerns, a significant proportion of respondents reported positive psychosocial effects, including improved relationships with spouses (15.1% strongly agreed, 15.1% agreed), increased social interactions (41.1% strongly agreed, 47.9% agreed), and enhanced confidence in the child (30.1%stronglyagreed, 34.2% agreed).Notably, 34.2% of respondents were neutral about the child’s confidence in interactions after the repair.CONCLUSION: The findings indicate that cleft lip repair at KATH positively impacts parental satisfaction and overall psychosocial wellbeing. While parents/guardians expressed overall satisfaction with the appearance of the lip, other facial features may require more attention during surgical planning and post-operative care to enhance overall outcomes. Addressing parental concerns and providing tailored support services can further optimise the psychosocial effects of cleft lip repair and promote positive family dynamics. Continued research and comprehensive support programs are essential to improve the care and satisfaction of parents/guardians of children with cleft lip after repair at KATH.
Evaluación de riesgos psicosociales que predisponen al síndrome de Burnout en el personal sanitario que labora en el Hospital Aida León de Rodríguez Lara
Authors: Auquilla-Soria Patricia Johanna , Mariño-Andrade Herny Geovanny 
Published: December 2024

En la presente investigación se aplicó 2 encuestas a 35 personas integrantes del personal sanitario que labora en el Hospital Aida León de Rodríguez Lara, la primera encuesta que actualmente se encuentra aprobada por el Ministerio de Trabajo del Ecuador que evalúa el riesgo psicosocial y la segunda encuesta que evalúa el Síndrome de Burnout mediante la escala MBI (INVENTARIO DE BURNOUT DE MASLACH), se analizó la información mediante el programa estadístico SPSS obteniendo que la mayor parte de la población se encuentra con un riesgo medio en cada una de las categorías, además que 22,85% de la población presenta síndrome de burnout. Por último, se pudo corroborar que muestran una relación muy fuerte entre el riesgo psicosocial del encuestado y el síndrome de burnout. (con un valor de p correspondiente a 0,643), esto significa que a mayor riesgo psicosocial mayor en la prevalencia de síndrome de burnout.
Ensuring the Right of Access to Information Due to the Need to Increase the Level of Information Security and Protect Public Interests
Authors: Digay Damir , Nurmukhankyzy Daniya , Alzhankulova Svetlana , Zhumagulov Timur , Kamidenova Karina 
Published: December 2024

The right to access information allows citizens to monitor government actions. When this right is violated or absent, it threatens state power being usurped or abused. The right to access information guarantees the realization of many human rights and civil freedoms. Public authorities must, while respecting national laws and international agreements, maintain a balance between public and private interests.

Objective: The study aims to identify the main directions for ensuring the right to access information in the context of improving information security and protecting public interests.

Method: The main research methods are source analysis and expert survey. Based on theoretical analysis, the study examines definitions of access to information and restrictions on access to information to ensure information security.

Results and Discussion: The expert survey results identify the components of the system to ensure access to information and better regulate restricted information to guarantee information security and protect public interests. The authors conclude that the regulatory framework for the information sphere developed in the Republic of Kazakhstan is a comprehensive system that, based on constitutional norms, adequately regulates information relations, balancing individual and state interests. This ensures citizens’ access to information as a characteristic of a democratic state while restricting access to information for personal and state security reasons.
Trends and Prospects for the Development of Industry Specialization: Regional Aspects
Authors: Ter-Grigoryants Anna , Shelukhina Elena , Statsenko Valeriya , Leonova Galina 
Published: December 2024

Objective: The article aims to substantiate the significance of assessing regional industry specialization and identifying key sectors in the socioeconomic development of the North Caucasus Federal District (Russia) based on the analysis of organizational turnover and the specialization coefficient.

Methods: An economic-statistical method was applied to evaluate each activity’s contribution to value-added creation and identify structural changes in the regional economy.

Results and Discussion: The largest investments in the North Caucasus Federal District have been directed toward replacing worn-out machinery and equipment and increasing production capacities while maintaining or expanding product ranges. This approach supports adaptation to sanctions. However, fluctuations in investment levels pose risks to achieving regional goals. The study shows that the highest risks to stable development are typical of the Republic of Ingushetia, the Karachay-Cherkess Republic, and the Republic of North Ossetia-Alania. These risks are minimal in the Kabardino-Balkarian Republic, Stavropol Territory, and the Chechen Republic.

Research Implications: The obtained specialization coefficients allow the authors to identify the leading sectors in the socioeconomic development of the North Caucasus Federal District.

Originality/Value: Identifying the prospects for industry specialization is essential for forming regional policy. The mechanism of regional specialization should account for existing resources and their mobility potential driven by investment. Government support through major import substitution projects also plays a crucial role. The developed risk matrix reflecting increases in fixed capital investment helps identify promising regional industry specializations.
The Phenomenon of Video Games: the Production of Digital Media of Everyday Life
Authors: Nikolaeva Evgeniya , Soldatova Nataliya , Nekrasov Mikhail , Nikolaev Mikhail , Kuzmina Elena 
Published: December 2024

Objective: The goal of this work is to explore video games as key determinants of the modern social environment and their impact on everyday life.

Theoretical Framework: The study draws on the conceptual frameworks of J. Huizinga and R. Caillois, who identified play as a central aspect of human life. According to this view, all human activities have a playful element, influencing thought, perception, and worldview. Games, while evolving externally, maintain a core social function throughout history.

Method: We apply Huizinga's approach to analyze how digital media transform the social, cognitive, and existential dimensions of life. Additionally, the concept of the "gamer-body" is developed using M. Merleau-Ponty's phenomenological-existential approach, focusing on the body's role in cognition and existence.

Results and Discussion: Video games unite people, raise ethical and social issues, and enhance the individual’s spiritual journey. They confront players with their own alterable nature, acting as a "portal" through which they discover their essence. Over time, video games have increasingly influenced the real world, transforming everyday life with competitive interactions, rating systems, and digital interfaces. The physical and cognitive functions of individuals are reshaped by these technologies, making digital presence an existential necessity.
Pendampingan Pembuatan Laporan Keuangan di Puskesmas Ampelgading
Authors: Dewi Mariana Puspa , Mulyaningtyas Mulyaningtyas , A Pipit Rosita 
Published: December 2024

Pengabdian kepada masyarakat ini berupa pembuatan laporan keuangan pada Puskesmas Ampelgading Malang adalah sebuah inisiatif untuk meningkatkan transparansi dan akuntabilitas pengelolaan keuangan di lembaga kesehatan masyarakat. Melalui kegiatan ini, dilakukan pemahaman mendalam terhadap struktur dan proses pengelolaan keuangan Puskesmas Ampelgading Malang, serta penerapan standar akuntansi yang relevan. Metodologi yang digunakan meliputi survei, analisis dokumentasi, serta pelatihan bagi staf terkait. Hasilnya, tercipta laporan keuangan yang lebih terstruktur, akurat, dan mudah dipahami oleh pemangku kepentingan, termasuk masyarakat setempat. Diharapkan, kegiatan ini dapat memberikan kontribusi positif dalam peningkatan efisiensi dan efektivitas pengelolaan keuangan Puskesmas, serta memperkuat kepercayaan masyarakat terhadap layanan kesehatan yang disediakan. Kata kunci: Laporan Keuangan, Transparansi, Akuntabilitas
PENGEMBANGAN "ANIS SNACK" MELALUI DIGITAL MARKETING DAN MEDIA SOSIAL
Authors: Kuntardina Ari , Anom Latifah , Rochmayanti Dewi 
Published: December 2024

AbstrakProgram pengabdian masyarakat dilaksanakan di Desa Ngradin, Kecamatan Padangan, Kabupaten Bojonegoro. Desa Ngradin memiliki sepuluh Usaha Mikro Kecil Menengah (UMKM). Permasalahan yang dihadapi UMKM adalah kurang memahami cara melakukan promosi melalui media sosial dan digital marketing. Salah satu UMKM tersebut adalah “Anis Snack” yang memproduksi camilan kerupuk. Dengan melakukan branding pada “Ánis Snack” diharapkan konsumen mengenali produknya. Kemudian “Anis Snack” dimotivasi untuk melakukan promosi produk melalui media sosial dan internet. Metode yang dilakukan dalam pendampingan adalah sebagai berikut: 1) Melakukan survey lokasi UMKM; 2) Kunjungan ke UMKM untuk menentukan solusi; 3) Persiapan pelaksanaan kegiatan; 4) Pelaksanaan kegiatan; 5) Monitoring dan evaluasi. Capaian luaran program adalah supaya produk semakin dikenal oleh konsumen serta peningkatan penjualan melalui digital marketing dan media sosial. Kata kunci: Camilan kerupuk, UMKM, branding, digital marketing, media sosial. DEVELOPMENT OF "ANIS SNACK" THROUGH DIGITAL MARKETING AND SOCIAL MEDIAAbstractThe community service program was carried out in Ngradin Village, Padangan District, Bojonegoro Regency. Ngradin Village has ten Micro, Small and Medium Enterprises (UMKM). The problem faced by UMKM is a lack of understanding of how to promote through social media and digital marketing. One of these UMKM is "Anis Snack" which produces cracker snacks. By branding "Ánis Snack", it is hoped that consumers will recognize the products. Then "Anis Snack" is motivated to promote products through social media and the internet. The methods of assistance are as follows: 1) Conducting a survey of UMKM locations; 2) Visits to UMKM and research to determine solutions; 3) Preparation for the implementation of activities; 4) Implementation of activities; 5) Monitoring and evaluation. The output of the program is to make the product more known by consumers and increase sales through digital marketing and social media. Keywords: Cracker snacks, UMKM, branding, digital marketing, social media.
Sistem Informasi Rapor Online Berbasis Website Menggunakan Metode Waterfall Pada SDIT Al Karima Kubu Raya
Authors: Hendini Ade 
Published: December 2024

Dengan jumlah siswa yang cukup banyak, tentunya proses untuk mendapatkan nilai akhir siswa menjelang pembagian rapor oleh seorang Guru Pengampu Mata Pelajaran membutuhkan waktu yang cukup panjang. Hal ini menjadikan Guru Wali Kelas harus menunggu pengiriman data nilai dari semua Guru Pengampu Mata Pelajaran terlebih dahulu, baru kemudian dapat melakukan proses input nilai ke dalam masing-masing rapor siswa. Jika Guru Pengampu Mata Pelajaran memberikan data nilai di waktu yang telah mendesak, pengisian rapor oleh Guru Wali Kelas pun menjadi terdesak pula yang memungkinkan terjadinya kekeliruan dan menyebabkan terbatasnya waktu pencetakan rapor. Sistem informasi rapor online berbasis website menggunakan metode Waterfall memungkinkan akses penginputan nilai yang terintegrasi antara Guru Pengampu Mata Pelajaran dan Wali Kelas dimana nilai siswa dihitung dan diproses oleh sistem sehingga didapat hasil akhir berupa rapor siswa yang siap dicetak. Metode penelitian menggunakan metode Waterfall. Dengan menggunakan sistem informasi rapor online ini dapat membuat penyajian nilai Rapor Siswa menjadi lebih cepat dan penghitungan nilai yang lebih akurat. Hal ini membuktikan bahwa sistem informasi rapor online dapat mengurangi resiko kesalahan penghitungan yang dilakukan secara konvensional
How corporate financial policies response to activist managers: evidence from Iraq
Authors: Mohammed Imad Abdul Aziz Mahdi  , Dr, Raghed Haqi Khaleel  , Zahraa Naser Ali  
Published: December 2024

This paper investigates whether the presence of activist managers in publicly traded firms affects financial policies. Our results show that activist managers increase managers’ strategic planning and corporate efficiency, confirming the notion that managerial-owned firms are more efficient than other counterparts. We find that the presence of activist managers increases their capital expenditure and has a positive effect on firm dividend payments. This efficiency leads ultimately to an increase in firm performance. Our results have important implications for investors and policy makers in Iraq and other under-developed markets where managers’ investors usually have substantial equity stakes in public firms.
Keywords: Managerial Activism, Financial Policy, Financial Decisions, Iraq.
Soil and ecological conditions of rare species of tulips in Zhambyl district of Almaty region
Authors: Kozybayeva F. E. , Dimeeva L. A. , Beiseeva G. B. , Toktar M. 
Published: December 2024

In the process of the study the general soil-ecological disturbances of the soil cover, i.e. anthropogenic, pasture digression, degradation, erosion processes were revealed. There is an intensified grazing of cattle, which significantly affects soil properties, first of all, physical ones. An indispensable consequence of overgrazing is soil compaction. The condition of soil and vegetation cover in pastures is the main factor of ecosystem stability. Excessive load on pastures leads to violation of integrity of ecosystem functioning and development of pasture digression. The elements of grazing regulation are the correspondence of the number of animals to the grazing area, pasture productivity and general control over the state of the natural environment. Compliance with the above requirements can be a guarantee of sustainable development of the ecosystem and preservation of rare plant species. Soil-ecological conditions of growing of endangered species of tulips Regel, Albert and Kolpakovsky were investigated on the territory of Zhambyl district of Almaty region.
Soils of the Caspian sea northern coast and their degradation
Authors: Pachikin K. M. , Erokhina O. G. , Yershibulov A. K. , Songulov E. E. , Molchanova E. A. , Nusilip A. 
Published: December 2024

The purpose of the research was to comprehensively assess the current state of the soil cover of the coastal zone of the Caspian Sea; identification of soil degradation processes. The objects of research are the soils and soil cover of the part of the northern coast of the Caspian Sea, adjacent to the modern delta of the Ural River. The transformation of the soils of the territory is due not only to the increased anthropogenic impact, but also to the change in soil formation factors associated with the decrease in the level of the Caspian Sea in recent years. To assess the degree of study of the characterized territory, the selection and analysis of materials from soil studies was carried out. Based on the results of soil studies on the territory of the site, 26 soil taxonomic units up to and including varieties were identified. The degree of soil degradation was assessed. On the basis of the materials obtained, a soil map and a map of soil degradation of the northern coast of the Caspian Sea were created.