bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methanol bioeconomy: promotion of rice crop yield in paddy fields with microbial cells prepared from natural gas‐derived C1 compound
Authors: Yurimoto Hiroya , Iguchi Hiroyuki , Di Thien Do Thi , Tani Akio , Okumoto Yutaka , Ota Atsushi , Yamauchi Takahiro , Akashi Takahiro , Sakai Yasuyoshi 
Published: December 2020

SummaryMethylotrophs, which can utilize methanol as a sole carbon source, are promising microorganisms to be exploited in a methanol‐based bioeconomy, in which a variety of useful compounds are biotechnologically produced from natural gas‐derived methanol. Pink‐pigmented facultative methylotrophs (PPFMs) are common plant phyllospheric bacteria and are known to enhance seedling growth and total biomass of various plants. However, improvement of crop yield by inoculation of PPFMs at the field level has not been well investigated. We herein describe improvement of crop yield of several rice cultivars by foliar spraying of PPFMs. After selection of PPFM strains and rice cultivars by the in vitro seedling growth test, we further conducted paddy field experiments. The crop yield of the sake‐brewing rice Oryza sativa cultivar Hakutsurunishiki was reproducibly improved in a commercial paddy field for over a 5‐year period. A one‐time foliar spray of PPFM cells (living or killed) or a cell wall polysaccharide fraction, after the heading date, acted in the phyllosphere and effectively improved crop yield. Our results show that the established process with PPFMs is feasible for improvement of food production in the methanol bioeconomy.
Viséan Fossil Plants from the Jiujialu Formation in Central Guizhou Province: Implications for Age of Bauxite and Palaeoenvironment
Authors: LUO Chaokun , YANG Ruidong , GAO Junbo , UMAIR Muhammad , WANG Longbo , GAO Lei 
Published: December 2020

AbstractFossil plants from the carbonaceous shale of upper part of the Lower Carboniferous Jiujialu Formation in Lindai bauxite deposit fill a gap regarding the distribution of Early Carboniferous flora in Central Guizhou Province. Here the Lindai plant assemblage is systematically described, and its composition and geological age are discussed. Research demonstrates that 9 species in 6 genera of the fossil plants are discovered in this study, and they belong to lycopsids, sphenopsids and ferns, respectively. Based on the analysis of the floral composition, the geological age of the Lindai plant assemblage belongs to the Early Carboniferous Viséan. The discovery of Lindai plant assemblage not only provides a new fossil evidence to restrict the age of bauxite deposits in Lower Carboniferous Jiujialu Formation of Central Guizhou Province, but also has great significance to further research the palaeoecological setting and floral evolution during the Early Carboniferous.
Delivery room cuddles for extremely preterm babies and parents: concept, practice, safety, parental feedback
Authors: Clarke Paul , Allen Emma , Atuona Sheila , Cawley Paul 
Published: December 2020

AbstractAimFollowing extreme preterm birth, there has traditionally been felt an imperative to rush baby to the neonatal unit for ongoing intensive care. Immediate needs of parents to bond with their babies through direct early physical contact have often been overlooked; many weeks can pass before parents get to hold their babies for the first time. Recognition of the importance of early contact is growing. We aimed to review the safety and value of routinely practising delivery room cuddles for extremely preterm babies.MethodsWe reviewed delivery room cuddles in babies born <27 weeks’ gestation in our centre between 2006 and 2017 via case‐control. We also conducted a questionnaire survey of mothers who experienced a delivery room cuddle to gain their feedback and perspectives.ResultsWe found no difference in age or temperatures on neonatal unit admission. There was no case of inadvertent extubation associated with cuddles. Parental feedback was very positive.ConclusionWith appropriate safeguards, delivery room cuddles are feasible and achievable for extremely preterm babies irrespective of birth gestation. Facilitation of the cuddle is an early and very important family‐centred care practice which seems much appreciated by parents and which may improve bonding, lactation, and maternal mental health.
Supporting families of children with an undiagnosed genetic condition: Using co‐design to ensure the right person is in the right post doing the right job
Authors: Oulton Kate , Gibson Faith , Williams Anna , Geoghegan Sophie , Aldiss Susie , Wray Jo 
Published: December 2020

AbstractBackgroundFamilies and professionals caring for a child without a definitive diagnosis face unique challenges, particularly in relation to managing uncertainty; access to healthcare; obtaining relevant information and support; and trying to navigate a healthcare system that is often fragmented. We used co‐design to inform the establishment of the first UK specialist nursing post dedicated to working with children with undiagnosed genetic conditions and their families. Objectives: (1) To understand what families and hospital staff want from the service; (2) To understand how the post should be operationalized in practice; (3) To develop the job description and person specification for the postholder.MethodsA range of approaches were used to collect data: interviews (nine parents and 10 hospital staff); a focus group (three parents); a creative workshop (six patients and siblings); and an online forum (81 parents). Data were analyzed using framework and thematic analysis. The strands of data were brought together and reviewed as a whole to formulate the postholder's job description and person specification.ResultsStakeholders identified nine key elements to the role which were incorporated into the job description: practical support; point of contact; community liaison; signposting to other services; care coordination; supporting families; advocacy; raising awareness; and emotional support.ConclusionsHighlighted in this paper are the practical aspects of engaging and involving all relevant stakeholders in the process of co‐designing a new post and subsequent staff recruitment. The flexibility employed in the setting and methods of data collection were instrumental in ensuring that the views of a diverse range of participants were ascertained. A major consideration is the resources required to undertake co‐design, in terms of time and finances. We believe that the resources required for the co‐design are offset by the advantages of having the right person in the right post, doing the right job.
The value of bronchoscopy in patients with non‐massive haemoptysis and a clear or benign computer tomogram scan
Authors: Murphy Declan C. , Jackson Karl , Johnston Robert , Welsh Sarah , Webster Rebecca , Lapsley Rebecca , Shah Hussun‐Ara , Mitchell Daniel , Aujayeb Avinash 
Published: December 2020

AbstractIntroductionThe preferred diagnostic pathway for patients presenting with non‐massive haemoptysis and normal or benign computer tomography (CT) radiological findings is unclear. The common approach is to investigate with both CT and bronchoscopy, irrespective of patient‐specific factors. The value of performing fibreoptic bronchoscopy (FOB) in patients with non‐massive haemoptysis and clear or benign CT findings remains undetermined. We aimed to investigate its value using a large retrospective case series.Material and MethodsA retrospective review of 4376 FOBs performed in Northumbria Healthcare NHS Foundation Trust from January 2012 to December 2019 for patients presenting with haemoptysis and clear or benign CT findings. Statistical analysis was performed to describe patient‐specific variables, clinical characteristics, pathological findings and subsequent management decisions.ResultsA total of 4376 FOBs were performed during the study period, 275 were indicated to investigate non‐massive haemoptysis. Two hundred and fifty‐nine patients underwent a CT scan (158 before and 101 after FOB); 16 never had a CT because the treating physician did not feel it was necessary. About 258 CT scans showed normal anatomy. All patients underwent FOB; 192 showed normal findings. Bronchoscopic findings did not alter clinical management in 274 patients. One patient was referred to the ear, nose and throat department following the identification of polypoid vocal cord lesion which, following thorough investigation, was confirmed as benign.ConclusionFOB provides minimal value for identifying lung malignancies in patients with non‐massive haemoptysis and a clear or benign CT scan irrespective of patient‐specific risk factors. Cost savings would be associated if physicians altered practice accordingly.
Measuring fatigue: a meta‐review
Authors: Machado Myrela O. , Kang Na‐Young Cindy , Tai Felicia , Sambhi Raman D. S. , Berk Michael , Carvalho Andre F. , Chada Lourdes P. , Merola Joseph F. , Piguet Vincent , Alavi Afsaneh 
Published: December 2020

AbstractThere is a lack of validated tools to measure fatigue in patients with inflammatory skin, neuropsychiatric, and medical disorders. The use of nonvalidated tools may compromise the quality of data. The purpose of this meta‐review was to evaluate existing fatigue scales commonly used to assess fatigue in other inflammatory conditions and to identify if there are scales that have been validated in dermatologic conditions. The PubMed/MEDLINE and SCOPUS databases were systematically searched from inception through March 10, 2020, in accordance with the PRISMA statement. Validated tools were identified and assessed according to their main measurement properties. The literature search identified 403 references, and eight studies were eligible and assessed in this review. The unidimensional fatigue scales included were the Functional Assessment of Chronic Illness Therapy – Fatigue (FACIT‐F), Brief Fatigue Inventory, Fatigue Severity Scale, Numerical Rating Scale – Fatigue, and Visual Analog Scale – Fatigue. The multidimensional fatigue scales found were the Checklist Individual Strength, Chalder Fatigue Scale, Multidimensional Assessment of Fatigue, Multidimensional Fatigue Inventory Scale, and Piper Fatigue Scale. To measure fatigue, a brief scale with the ability to detect change is needed as there is a growing interest in evaluating this dimension of treatment response. In addition, a good content validity is also needed. From this systematic review, none of the selected scales have had content validation, even though the FACIT was validated in patients with psoriatic arthritis. Validation studies in specific disorders are urgently warranted.
Beyond talk: Contributions of quantity and quality of communication to language success across socioeconomic strata
Authors: Masek Lillian R. , Paterson Sarah J. , Golinkoff Roberta Michnick , Bakeman Roger , Adamson Lauren B. , Owen Margaret Tresch , Pace Amy , Hirsh‐Pasek Kathy 
Published: December 2020

AbstractInfants from low‐socioeconomic status (SES) households hear a projected 30 million fewer words than their higher‐SES peers. In a recent study, Hirsh‐Pasek et al. (Psychological Science, 2015; 26: 1071) found that in a low‐income sample,fluency and connectednessin exchanges between caregivers and toddlers predicted child language a year later over and above quantity of talk (Hirsh‐Pasek et al.,Psychological Science, 2015; 26: 1071). Here, we expand upon this study by examiningfluency and connectednessin two higher‐SES samples. Using data from the NICHD Study of Early Child Care and Youth Development, we sampled 20 toddlers who had low, average, and high language outcomes at 36 months from each of 2 groups based on income‐to‐needs ratio (INR; middle and high) and applied new coding to the mother–toddler interaction at 24 months. In the high‐INR group, the quality of mother–toddler interaction at 24 months accounted for more variability in language outcomes a year later than did quantity of talk, quality of talk, or sensitive parenting. These results could not be accounted for by child language ability at 24 months. These effects were not found in the middle‐INR sample. Our findings suggest that when the quality of interaction,fluency and connectedness, predicts language outcomes, it is a robust relation, but it may not be universal.
Effect of clinical teaching behaviours on transition shock in graduate nurses
Authors: Su Qian , Jiang Mengyao , Yun Bei , Ma Yuxia , Zuo Yamei , Han Lin 
Published: December 2020

AbstractAimThis study aimed to explore the impact of preceptor clinical teaching behaviours on transition shock in graduate nurses using bi‐directional feedback between graduate nurses and clinical preceptors and to assess preceptor clinical teaching behaviours.DesignThis was a descriptive cross‐sectional study.MethodsThis study was conducted from January‐February 2019. Participants included graduate nurses (N = 117) and clinical preceptors (N = 908) from a major public tertiary hospital in Western China.ResultsOverall level of transition shock of graduate nurses was moderate (mean = 89SD 17.54). Transition shock level of graduate nurses rose with the increasing of time in clinical work. Intensive care unit graduate nurses suffered the strongest transition shock, whereas surgery graduate nurses suffered the least. Graduate nurses thought that clinical preceptors were best at evaluation and feedback, whereas clinical preceptors thought they were best at showing concern and support. The primary factors associated with transition shock in graduate nurses were the time admitted to the hospital, feedback, and evaluation, use of appropriate teaching strategies, and showing concern and support, explaining 63.5% of the total variation in transition shock in graduate nurses.ConclusionIn Western China, where the development of economic and medical conditions lag, transition shock is a major obstacle to the professional development of graduate nurses and clinical teaching behaviours is the key to overcoming transition obstacles. However, the serious shortage of nurses makes it difficult to not only complete heavy clinical nursing work but also to undertake the teaching of students and graduate nurses. The clinical teaching system is influenced by many factors. Focusing on clinical teaching behaviours and transition shock in graduate nurses will provide valuable data for future intervention studies.ImplicationThe findings of this study will be of interest to managers at all levels and will enable them to support graduate nurses by engaging in excellent clinical teaching behaviours. In the clinical teaching process, giving more feedback and evaluation, improving the ability of using appropriate teaching strategies and focusing on the physical and mental health of graduate nurses may effectively decrease transition shock of graduate nurses and reduce the turnover rate.
Group climate, aggressive incidents and coercion in a secure forensic setting for individuals with mild intellectual disability or borderline intellectual functioning: A multilevel study
Authors: Neimeijer Elien G. , Delforterie Monique J. , Roest Jesse J. , van der Helm Peer , Didden Robert 
Published: December 2020

AbstractBackgroundThis study examines associations between group climate, aggressive incidents and coercive measures in adults with mild intellectual disability or borderline intellectual functioning (MID‐BIF) of a secure forensic setting.MethodParticipants (N = 248) were interviewed about their perception of group climate utilizing the Group Climate Instrument. Data on aggressive incidents and coercive measures were retrieved from the facilities’ electronic database. A multilevel structural equation model was fitted in which variability in perception of group climate within and between living groups was examined.ResultsAn open and therapeutic group climate was associated with lower levels of aggression within and between groups. A higher number of aggressive incidents were significantly associated with a higher number of coercive measures.ConclusionsThe findings have implications for the understanding of how group climate may play a role in reducing aggressive incidents at the living group in treatment of individuals with MID‐BIF in secure forensic settings.
The use of antifungal oat‐sourdough lactic acid bacteria to improve safety and technological functionalities of the supplemented wheat bread
Authors: Hajinia Fahimeh , Sadeghi Alireza , Sadeghi Mahoonak Alireza 
Published: December 2020

AbstractIn the present study, predominant lactic acid bacteria (LAB) were isolated from oat sourdough. Then, the isolates were screened based on their in vitro antifungal activity. Subsequently, biotechnological capabilities of the selected LAB were evaluated in wheat bread supplemented with controlled fermented oat containing the isolate. Pediococcus pentosaceus was molecular identified as predominant antifungal isolate. Based on our results, fermented oat not only significantly (p < .05) reduced the mold expansion on the produced breads, but also improved the quality attributes of the product. Crumb porosity and antioxidant capacity of the supplemented bread revealed the positive effects of the isolate on textural and functional characteristics of the enriched bread. Wheat bread supplemented with controlled fermented oat had also the highest 2,2‐diphenyl‐1‐picrylhydrazyl radical scavenging activity compared to the other samples. Accordingly, the potential applications of P. pentosaceus isolate as profunctional starter culture in processing of mixed wheat‐oat sourdough bread were verified.
Association of Non‐Steroidal Anti‐Inflammatory Drugs with Kidney Health in Ambulatory Older Adults
Authors: Amatruda Jonathan G. , Katz Ronit , Peralta Carmen A. , Estrella Michelle M. , Sarathy Harini , Fried Linda F. , Newman Anne B. , Parikh Chirag R. , Ix Joachim H. , Sarnak Mark J. , Shlipak Michael G. ,   for the Health ABC Study
Published: December 2020

Background/ObjectivesNon‐steroidal anti‐inflammatory drugs (NSAIDs) can cause kidney injury, especially in older adults. However, previously reported associations between NSAID use and kidney health outcomes are inconsistent and limited by reliance on serum creatinine‐based GFR estimates. This analysis investigated the association of NSAID use with kidney damage in older adults using multiple kidney health measures.DesignCross‐sectional and longitudinal analyses.SettingMulticenter, community‐based cohort.ParticipantsTwo thousand nine hundred and ninty nine older adults in the Health ABC Study. A subcohort (n = 500) was randomly selected for additional biomarker measurements.ExposurePrescription and over‐the‐counter NSAID use ascertained by self‐report.MeasurementsBaseline estimated glomerular filtration rate (eGFR) by cystatin C (cysC), urine albumin‐to‐creatinine ratio (ACR), kidney injury molecule‐1 (KIM‐1), and interleukin‐18 (IL‐18) were measured in 2,999 participants; alpha‐1 microglobulin (α1m), neutrophil gelatinase‐associated lipocalin (NGAL), propeptide type III procollagen (PIIINP), and uromodulin (UMOD) were measured in 500 participants. GFR was estimated three times over 10 years and expressed as percent change per year.ResultsParticipants had a mean age of 74 years, 51% were female, and 41% African‐American. No eGFR differences were detected between NSAID users (n = 655) and non‐users (n = 2,344) at baseline (72 ml/min/1.73 m2 in both groups). Compared to non‐users, NSAID users had lower adjusted odds of having ACR greater than 30 mg/g (0.67; 95% confidence interval (CI) = 0.51–0.89) and lower mean urine IL‐18 concentration at baseline (−11%; 95% CI = −4% to −18%), but similar mean KIM‐1 (5%; 95% CI = −5% to 14%). No significant differences in baseline concentrations of the remaining urine biomarkers were detected. NSAID users and non‐users did not differ significantly in the rate of eGFR decline (−2.2% vs ‐2.3% per year).ConclusionSelf‐reported NSAID use was not associated with kidney dysfunction or injury based on multiple measures, raising the possibility of NSAID use without kidney harm in ambulatory older adults. More research is needed to define safe patterns of NSAID consumption.
Plant plasma membrane‐resident receptors: Surveillance for infections and coordination for growth and development
Authors: Escocard de Azevedo Manhães Ana Marcia , Ortiz‐Morea Fausto Andres , He Ping , Shan Libo 
Published: December 2020

AbstractAs sessile organisms, plants are exposed to pathogen invasions and environmental fluctuations. To overcome the challenges of their surroundings, plants acquire the potential to sense endogenous and exogenous cues, resulting in their adaptability. Hence, plants have evolved a large collection of plasma membrane‐resident receptors, including RECEPTOR‐LIKE KINASEs (RLKs) and RECEPTOR‐LIKE PROTEINs (RLPs) to perceive those signals and regulate plant growth, development, and immunity. The ability of RLKs and RLPs to recognize distinct ligands relies on diverse categories of extracellular domains evolved. Co‐regulatory receptors are often required to associate with RLKs and RLPs to facilitate cellular signal transduction. RECEPTOR‐LIKE CYTOPLASMIC KINASEs (RLCKs) also associate with the complex, bifurcating the signal to key signaling hubs, such as MITOGEN‐ACTIVATED PROTEIN KINASE (MAPK) cascades, to regulate diverse biological processes. Here, we discuss recent knowledge advances in understanding the roles of RLKs and RLPs in plant growth, development, and immunity, and their connection with co‐regulatory receptors, leading to activation of diverse intracellular signaling pathways.
Glucocorticoid‐mediated mechanisms of hippocampal damage: Contribution of subgranular neurogenesis
Authors: Podgorny Oleg V. , Gulyaeva Natalia V. 
Published: December 2020

AbstractA comprehensive overview of the interplay between glucocorticoids (GCs) and adult hippocampal neurogenesis (AHN) is presented, particularly, in the context of a diseased brain. The effectors of GCs in the dentate gyrus neurogenic niche of the hippocampal are reviewed, and the consequences of the GC signaling on the generation and integration of new neurons are discussed. Recent findings demonstrating how GC signaling mediates impairments of the AHN in various brain pathologies are overviewed. GC‐mediated effects on the generation and integration of adult‐born neurons in the hippocampal dentate gyrus depend on the nature, severity, and duration of the acting stress factor. GCs realize their effects on the AHN primarily via specific glucocorticoid and mineralocorticoid receptors. Disruption of the reciprocal regulation between the hypothalamic–pituitary–adrenal (HPA) axis and the generation of the adult‐born granular neurons is currently considered to be a key mechanism implicating the AHN into the pathogenesis of numerous brain diseases, including those without a direct hippocampal damage. These alterations vary from reduced proliferation of stem and progenitor cells to increased cell death and abnormalities in morphology, connectivity, and localization of young neurons. Although the involvement of the mutual regulation between the HPA axis and the AHN in the pathogenesis of cognitive deficits and mood impairments is evident, several unresolved critical issues are stated. Understanding the details of GC‐mediated mechanisms involved in the alterations in AHN could enable the identification of molecular targets for ameliorating pathology‐induced imbalance in the HPA axis/AHN mutual regulation to conquer cognitive and psychiatric disturbances.
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