bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of Asthma in Polycystic Ovary Syndrome Women: A Meta-analysis
Authors: Sun Honghao , Li Da , Jiao Jiao , Liu Qing , Bian Jiansu , Wang Xiuxia 
Published: December 2020

Abstract
Background: A few publications have reported the prevalence of asthma in polycystic ovary syndrome (PCOS) patients. But it remains debatable whether PCOS is an independent risk factor of asthma. Thus we carried out this systematic review and meta-analysis to assess the association between PCOS and asthma.Methods：PubMed, Embase, web of science, Scopus, Cochrane trial register, China National Knowledge Infrastructure (CNKI) and Wanfang Databases were searched for studies published from inception to October 2020. We extracted the data and performed the meta-analysis under the guidance of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We used a random-effects model and calculated the odds ratios (ORs) and 95% confidence intervals (95% CIs).Results：A total of 6 articles concerning 26876 PCOS women and 156143 healthy controls were included. According to the result of the study, PCOS patients have increased risk of asthma (OR=1.75, 95%CI=1.40–2.19, I2=91.2%, P=0.000, random-effects model). When stratified by region, diagnostic cirteria for asthma and study design, the results did not show significant difference.Conclusions： PCOS leads to higher asthma risk, and this association is independent to region, diagnostic cirteria for asthma and study design.
Digital Cell Atlas of Mouse Uterus: From Regenerative Phase to Maturational Phase
Authors: Zhang Leyi , Wu Bingbing 
Published: December 2020

Abstract
Background: Endometria undergo repeated repair and regeneration during the menstrual cycle. Using gene expression to define the menstrual cycle has been seen in a couple of researches, which shares little consistency. The possible reason lies in the fact that the composition of each specimen is different. The objective of this study was to reconstruct an integrated cell atlas of mouse uterus from the regenerative to maturational endometrium at the single-cell level.Methods: We used published single-cell RNA sequencing data of mice uteri to build an integrated cell atlas, including epithelial cells, stromal cells, and immune cells. Principal components analysis, hierarchical clustering, and other data mining procedures were performed with R software. Functional enrichment analyses were performed to identify the potential biological roles of molecular changes in different mice estrus states.Results: Based on the expression level of proliferating cell nuclear antigen and gene ontology terms, we reconstructed the cell atlas and delineated in detail the transitions that happened during the estrus cycle. We also depicted the transition and transcription factors that shaped the differentiation of ESCs and the mononuclear phagocyte system. Besides, the amounts and functions of immune cells varied sharply in two periods. We also found clues about uterus tissue-resident macrophages and Pdgfrb+ Aldh1a2+ Cd34+ endometrial mesenchymal stem cells in vivo.Conclusions: The cell atlas of mouse uterus presented here would improve our understanding of the functional changes that occurred in the endometrium and helped us identify abnormalities that have not been apparent histologically.
Spontaneous Pregnancy with Severe Ovarian Hyperstimulation Syndrome Undergoing IVF-ET Cycle: A Case Report and Review
Authors: Peng Chaonan , Wang Zhixiao 
Published: December 2020

Abstract
It is relatively rare that a natural spontaneous with severe ovarian hyperstimulation syndrome (OHSS) occurs undergoing in vitro fertilization and embryo transfer (IVF-ET).Pregnancy can cause OHSS to be delayed, and even lead to pregnancy loss in severe cases.In this case, we introduced the case of a 32-year-old female infertile patient with PCOS who underwent IVF-ET cycle and developed severe OHSS before embryo transfer. After volume expansion, symptomatic and supportive treatment and four times of abdominal puncture to extract ascites, the patient's condition is still protracted.However, interestingly, two weeks after giving up treatment, the patient found a spontaneous pregnancy and ended up with biochemical pregnancy. Severe OHSS was also gradually self-healing after biochemical pregnancy.This case emphasizes that pregnancy is one of the high-risk factors of OHSS, which can lead to the delay of the patient's condition with OHSS. Clinicians should be alert to the possibility of spontaneous pregnancy when they take luteal phase ovulation induction treatment undergoing IVF-ET cycle.
Oil Price and Covid-19: Pandemic Vs Epidemic
Authors: TAN YAN-LING , hee yiew thian , HABIBULLAH MUZAFAR SHAH 
Published: December 2020

Abstract
The objective of this study is to contribute to the existing studies on the effects of COVID-19 on oil prices from the period spanning December 31, 2019 to June 29, 2020 by using the autoregressive distributed lag (ARDL) bounds test. The sample period is divided into the epidemic period (December 31, 2019 -March 10, 2020) and the pandemic period (March 11, 2020 to June 29, 2020). The results confirm there exist a cointegrating relation between oil price and COVID-19 for the entire period spanning December 2019 to June 2020. The COVID-19 has a negative impact on crude oil prices in the long-run irrespective of the indicator of the COVID-19 used in the study. Moreover, the estimates using Fully Modified Ordinary Least Squares (FMOLS), Dynamic Ordinary Least Squares (DOLS) and Canonical Cointgerating Regression (CCR) are similar to the ARDL framework. Overall, the presence of cointegrating relation can only be noticed over the entire period, but not when considering for the epidemic and pandemic periods
Cognitively Normal APOE ε4 Carriers Have Specific Elevation of CSF SNAP-25
Authors: Butt Omar Hameed , Long Justin M , Henson Rachel L. , Herries Elizabeth , Sutphen Courtney L. , Fagan Anne M. , Cruchaga Carlos , Ladenson Jack H. , Holtzman David M. , Morris John C. , Ances Beau. M. , Schindler Suzanne Elizabeth 
Published: December 2020

Abstract
Background: Cerebrospinal fluid (CSF) synaptosomal-associated protein 25 (SNAP-25) and neurogranin are recently described biomarkers for synaptic integrity that are known to be elevated in the CSF of symptomatic Alzheimer disease (AD). Their relationship with Apolipoprotein E (APOE) ε4 carrier status, the major genetic risk factor for AD, remains unclear.Methods: In this study, CSF SNAP-25 and neurogranin were compared in cognitively normal APOE ε4 carriers and non-carriers (n=274, mean age 65.0 ± 9.0 years, 39% APOE ε4 carriers, 58% female) enrolled at the Knight Alzheimer Disease Research Center, and in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database.Results: SNAP-25, a biomarker of pre-synaptic integrity, was specifically elevated in APOE ε4 carriers versus non-carriers (5.95 ± 1.72 pg/ml, 4.44 ± 1.40 pg/ml, p <0.0001), even after adjusting for age, sex, years of education, and amyloid status (p <0.0001). In contrast, CSF neurogranin, a biomarker of post-synaptic integrity, did not vary by APOE ε4 status. Further, CSF total tau (t-tau), phosphorylated-tau-181 (ptau181), and neurofilament light chain (NfL) also did not vary by APOE ε4 status. Similar results were observed in the ADNI cohort. Conclusion: Our findings suggest APOE ε4 carriers have both amyloid-related and amyloid-independent presynaptic disruption as reflected by elevated CSF SNAP-25 levels. In contrast, post-synaptic disruption as reflected by elevations in CSF neurogranin is related to amyloid status.
­­­­­­­­­Surgical Resection Compared to Medical Management in localized Mycobacteria Avium Complex­­­ Pulmonary Infection­­­­s-A Case Control Study
Authors: Fregoso Gabriel , Dhiman Rakesh , Lanuti Michael , Wain John , Hurtado Rocio , Richards Christopher J , O'Donnell Walter , Farhat Maha 
Published: December 2020

Abstract
Background

Pulmonary infections associated with Mycobacterium avium complex can be challenging to treat medically and the role of surgical lung resection is not well established. We aim to assess safety and microbiologic response in patient with localized Mycobacterium avium complex pulmonary infections managed with surgical lung resection compared to medical management alone.
Methods

We present a multi-institutional case series of 16 patients with localized Mycobacterium avium complex pulmonary infections managed with surgical lung resection. We highlight the case of a 30 to 40-year-old patient with localized pulmonary disease amenable to surgical resection for illustrative purposes and report on outcomes compared with medically treated patients at the same institution in case-control design.
Results

Of 745 patients meeting microbiologic diagnostic criteria for Mycobacterium avium complex pulmonary infections, 98 had localized pulmonary disease and of these 16 underwent surgical resection. Univariate and multivariate analysis results indicated no difference in surgical resection group compared with medical treatment: microbiologic response rate (odds ratio 0.49, 0.1–2.41), 2-year all-cause mortality (odds ratio 0.87, 0.18–4.32), and composite outcome of 2-year mortality and lack of microbiological response (multivariate logistic regression OR = 0.45, 0.09–1.57).
Conclusions

This case series describes patients with localized pulmonary Mycobacterium avium complex for whom surgical resection was pursued and shows examples of patients that may benefit from surgery. Though surgery for pulmonary Mycobacterium avium complex disease is rarely performed, it appears as safe and at least as effective as medical-therapy alone.
Enteral Lactoferrin Administration Attenuates Myocardial Ischemia-Reperfusion Injury in an Isolated Rat Heart Model
Authors: Omiya Keisuke , Nakadate Yosuke , Oguchi Takeshi , Sato Tamaki , Matsuoka Toru , Abe Masako , Kawakami Akiko , Matsukawa Takashi , Sato Hiroaki 
Published: December 2020

Abstract
Background

While lactoferrin, an iron-binding glycoprotein, has protective effects on intestinal and cerebral ischemia-reperfusion injuries, its cardioprotective effects against stunned myocardium are unknown. This study aimed to test the hypothesis that lactoferrin has cardioprotective effects against stunned myocardium.
Methods

Rat hearts were perfused using the Langendorff system, and two experiments were performed. In experiment 1, the hearts were divided into the enteral lactoferrin (E-LF) 7.5 m, 15 m, 30 m, and 60 m groups, where lactoferrin (1000 mg/kg) was administered enterally for 7.5, 15, 30, and 60 min, respectively, before perfusion; and a control group, where saline was administered 30 min before perfusion. In experiment 2, hearts were allocated to the perfusate lactoferrin (P-LF) 15 and 100 groups, where 15 mg/L and 100 mg/L lactoferrin were respectively added to the perfusate, and a control group. Each group was perfused for 20 min prior to 15 min of no-flow ischemia with pacing, followed by 20 min of reperfusion. The primary outcome was the maximum left ventricular derivative of pressure development (LV dP/dt max) 15 min after reperfusion. Myocardial phospho-protein kinase B (p-Akt) was assayed by western blotting.
Results

LV dP/dt max in the E-LF 15 m and 30 m groups was significantly higher than in the control group. In the second experiment, there were no significant differences in LV dP/dt max. Myocardial p-Akt was not significantly activated in any lactoferrin group.
Conclusion

Cardio-protection was observed with enteral but not parenteral lactoferrin administration, and myocardial p-Akt was not involved in this effect.
Serum Total Protein, Albumin, Globulin, and Prealbumin in Acne Patients
Authors: Jiang Hao , Li Changyi , wei bin , Wang Qiang , Wang Qinggao , Ye Xingjiang , Zhou Lu , Lu Bin , Lin Hongsheng , Shao Yang , Lin Yinghui , Wu Zhihong , Zhong Jiang , Lu Jianqi 
Published: December 2020

Abstract
Background/Objectives: This study was designed to investigate serum protein levels in acne patients.Method: Acne patients (n=362) and healthy volunteers (n=272) were matched in terms of both age and sex. Serum levels were measured.Results: Among the 362 acne patients and 272 age- and sex-matched healthy controls, serum albumin levels in female acne patients were lower than in the healthy controls (P < 0.05), serum albumin levels in male acne patients were lower than in the healthy controls (P < 0.01). Additionally, serum globulin and total protein levels were significantly lower in acne patients than in the healthy control group (P < 0.01). Serum levels of prealbumin were significantly lower in female acne patients than in the control group (P < 0.05). Finally, the severity of female and male acne patients was negatively correlated with serum total protein, albumin, globulin, and prealbumin levels. Conclusions: The results of this study suggested that acne patients are potentially accompanied with protein malnutrition.
Dietary Determinants of Esophageal Cancer in Arsi Zone, Central Ethiopia: A Case-Control Study
Authors: Deybasso Haji Aman , Roba Kedir Teji , Nega Berhanu , Belachew Tefera 
Published: December 2020

Abstract
Background: Esophageal cancer is ranked 5th of all types of malignancies in Ethiopia following uterine, cervical, breast, and colorectal cancers. The findings regarding the dietary risk factors associated with an increased incidence of esophageal cancer were inconsistent. Methods: A matched case-control study was conducted from from June 1, 2019, to June 30, 2020. A total of 104 cases and 208 controls were involved. Cases were consecutively recruited from higher referral hospitals and matched to two population-based controls (1:2 ratio) on age, sex, and residence/altitude. Data were collected using structured questionnaires, coded and entered into the EPI info version7, and transported to SPSS software version 23. Binary and multiple logistic regressions were conducted to check the association between independent and dependent variables. Adjusted odds ratios and the corresponding 95% confidence intervals were estimated to assess the strength of association. P-values <0.05 were used to declare statistical significance. Results: Cooking foods in a living room (AOR=2.8,[95% CI:( 1.11,7.38), teeth loss ( AOR= 4.4, [95%CI:(1.87,10.56),consumption of very hot porridge (AOR=4.2 [95% CI:(2.08, 8.72),drinking very hot coffee (AOR=3.9 [95% CI:(1.70,8.93),drinking large volume of coffee at a time (AOR=6.3 [95% CI:(2.93,13.78), eating porridge fast (AOR=9.2[95% CI:(2.98, 28.88) were positively associated with esophageal cancer.Conclusion: Multiple dietary practices were associated with an increased risk of esophageal cancer. The findings imply the need for behavior change communication targeting cooking and consumption behaviors to curb the problem of esophageal cancer in the study community.
A Study on the Agreement of Body Temperatures Measured by Infrared Cameras and Oral Thermometry
Authors: Adams Scott , Bucknall Tracey , Kouzani Abbas 
Published: December 2020

Abstract
Background: The COVID-19 pandemic has led to the rapid adoption and rollout of thermal camera-based Infrared Thermography (IRT) systems for fever detection. These systems use facial infrared emissions to detect individuals exhibiting an elevated core-body temperature, which is present in many symptomatic presentations of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Despite the rollout of these systems, there is little independent research supporting their efficacy. The primary objective of this study was to assess the precision and accuracy of IRT screening solutions in a real-world scenario.Methods and Findings: A single-centre, observational study investigated the agreement of three IRT systems compared to digital oral thermometer measurements of body temperature. Over five days, 107 measurements were taken from individuals wearing facial masks. During each entry, two measurements of the subject’s body temperature were made from each system to allow for the evaluation of the measurement precision, followed by an oral thermometer measurement. Each participant also answered a short demographic survey. This study found that the precision of the IRT systems was wider than 0.3 °C claimed accuracy of two of the systems. This study also found that the IRT measurements were only weakly correlated to those of the oral temperature. Additionally, it was found that demographic characteristics (age, gender, skin colour, mask-type) impacted the measurement error.Conclusions: This study indicates that using IRT systems in front-line scenarios poses a potential risk, where a lack of measurement accuracy could possibly allow febrile individuals to pass through undetected. Further research is required into methods which could increase accuracy and improve the techniques viability.
Assessing Multisectoral Coordination for Nutrition Policy Effectiveness: Analysis of Facilitators, Constraints and Solutions for Implementation in Ethiopia
Authors: Kennedy Eileen , Kershaw Meghan , Biadgilign Sibhatu , Gizaw Rahel , Stickland Jennifer 
Published: December 2020

Abstract
BackgroundEffective implementation is an essential element for achieving success in multisector nutrition plans. The present study is follow-up to research conducted in 2013 - 2014. The current research utilizes the same protocol and targets the same regions of Ethiopia that were included in the initial study. The aim of the present research is to ascertain the factors that have enabled and sustained effective multisectoral coordination to inform ongoing support for multisector coordination through current activities.MethodsThe study was qualitative with purposing sampling of twelve woredas, each of which represented one of three groups receiving different levels of interventions under the initial study. Data was collected through Key Informant Interviews of the heads of the woreda-level sector offices using a standardized and semi-structured questionnaire. Focus Group Discussions were also held with nutrition focal/technical personnel working in different sectors, purposefully selected from relevant woreda sectors. Coding and analysis were done using Atlas.ti 8.1.3. ResultsResults indicate that progress has been made on key elements such as awareness of multisector nutrition plans and organization and functionality of the technical committees, however, competing priorities and lack of leadership and understanding of roles and responsibilities have hindered the effectiveness of regional coordination structures and implementation of the Government of Ethiopia’s National Nutrition Program.ConclusionsIn order to address the gaps and constraints to effective implementation of the National Nutrition Program identified in the present study, different strategies need to be employed to create better awareness, ownership, understanding, and motivation for policy/decision making officials, technical experts, coordinating bodies, and supporting organizations. This paper provides recommendations to address these and future challenges for effective implementation of multisectoral coordination for nutrition policy effectiveness in the post-2020 period.
Cord blood Advanced Lipoprotein Testing shows an interaction between gestational diabetes and birth-weight: an observational study
Authors: Algaba-Chueca Francisco , Maymó-Masip Elsa , Ballesteros Mónica , Guarque Albert , Freixes Olga , Amigó Núria , Fernández-Veledo Sonia , Vendrell Joan , Megia Ana 
Published: December 2020

Abstract
Background

Abnormal lipid metabolism is observed in gestational diabetes mellitus (GDM) and in neonates with abnormal fetal growth, however, how these alterations specifically affect the umbilical cord blood lipoprotein profile is not well understood.
Objective

To assess the impact of GDM on the cord blood lipoprotein profile across birth-weight categories by using Advanced Lipoprotein Testing.
Methods

observational study involving 74 control and 62 GDM pregnant women and their offspring. Newborns were classified according to birth-weight as small (n = 39), adequate (n = 50) or large (n = 49) for gestational age (SGA, AGA and LGA, respectively). Two-dimensional diffusion-ordered 1H-NMR spectroscopy was used to profile umbilical cord serum lipoproteins. One hundred and three children were available in a two years follow-up study to evaluate associations between cord blood lipid profile and obesity.
Results

Baseline characteristics of the two groups were similar except for gestational weight gain. The size, lipid content, number and concentration of particles within their subclasses were similar between offspring born to GDM and control mothers. Using two-way analysis of variance, we observed an interaction between GDM and birth-weight categories for IDL-cholesterol content and IDL- and LDL-triglyceride content, and the number of medium VLDL and LDL particles, specifically in AGA neonates. Small LDL particles were independently associated with offspring obesity at two years.
Conclusions

In this selected cohort, GDM disturbs triglyceride and cholesterol lipoprotein content across birth-weight categories, and AGA neonates born to GDM mothers display a profile more similar to adults with dyslipidemia and atherosclerosis than to those born to mothers with normal glucose tolerance.
Deep vein thrombosis and major adverse limb events in diabetic patients: a population-based cohort study
Authors: Wang Po-Chang , Chen Tien-Hsing , Chung Chang-Min , Chen Mei-Yen , Chang Jung-Jung , Lin Yu-Sheng , Chu Pao-Hsien , Peng Yun-Shing , Lin Ming-shyan 
Published: December 2020

Abstract
Background

Little is known about the association between deep vein thrombosis (DVT) and arterial complications in patients with type 2 diabetes. The aim of this retrospective cohort study was to assess the influence of prior DVT on major adverse limb events (MALEs) and major adverse cardiovascular events (MACEs) in patients with type 2 diabetes.
Methods

Patients with type 2 diabetes with or without a history of DVT hospitalization from 2001 to 2013 were identified in the National Health Insurance Research Database of Taiwan and included in this study. Propensity score matching was used to balance the baseline characteristics between groups. Cox proportional and Fine and Gray subdistribution hazard models were used to examine association a between history of DVT and the risks of MALEs and MACEs.
Results

During a mean follow-up of 5.2 years (standard deviation: 3.9 years), the DVT group (n = 2017) had a higher risk of MALE composite outcome (8.4% vs. 5.2%; subdistribution hazard ratio [SHR] 1.60, 95% CI 1.34–1.90). Among the individual components, the DVT group had higher risks of foot ulcer (5.2% vs. 2.6%, SHR 1.96, 95% CI 1.57–2.45), gangrene (3.4% vs. 2.3%, SHR 1.44, 95% CI 1.10–1.90) and amputation (2.5% vs. 1.7%; SHR 1.42, 95% CI 1.03–1.95).
Conclusions

The presence of DVT may be associated with an increased risk of MALEs, major amputation, and thromboembolism, contributing to a higher risk of mortality in patients with type 2 diabetes.