bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health, well-being, and material-ideal hybrid spaces in Yeats’s writing
Authors: Balinisteanu Tudor 
Published: November 2020

Traditionally regarded as high-art, poetry is often seen as a superior form of literary achievement consecrating in verse worldviews and lives connected to ideal, transcendental realms, the pursuance of which supposedly leads to some kind of ideal health and spiritual well-being. The poet WB Yeats (Nobel Prize in Literature, 1923), who believed in the power of poetry to reveal realities and states of such perfection, thereby giving purpose to mundane life, likened this effect of poetry to the fashioning of statues as monuments of unageing intellect. However, contradictorily, he also questioned the value of poetry thus conceived by questioning whether it is healthy to aspire to embody poetically consecrated ideals in real life. Yeats’s dilemmatic negotiation between these two positions suggests that better personal well-being can be achieved in living an enlightening life by being mindful of the body’s sensuality and materiality. In poetic explorations of the ways in which idealism and sensuality can affect how we live our lives, Yeats used real-life examples of people he knew, often important public figures in Irish social and political history.The present paper frames these explorations in terms of Yeats’s concepts of living stream and stone/statuary, augmented with Bruno Latour’s concepts of traditional subject and articulated body, discussed in relation to purpose in life and closeness and empathy, proposing that an overly idealistic ‘poetic’ lifestyle can have adverse effects, whereas poetry that increases one’s awareness of oneself as articulated body is conducive to better health and well-being.
Cysteine-Altering
NOTCH3
Variants Are a Risk Factor for Stroke in the Elderly Population
Authors: Hack Remco J. , Rutten Julie W. , Person Thomas N. , Li Jiang , Khan Ayesha , Griessenauer Christoph J. ,   Regeneron Genetics Center, Abedi Vida , Lesnik Oberstein Saskia A.J. , Zand Ramin 
Published: November 2020

Background and Purpose:

Cysteine altering
NOTCH3
variants, which have previously been exclusively associated with the rare hereditary small vessel disease cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, have a population frequency of 1:300 worldwide. Using a large population database, and taking genotype as a starting point, we aimed to determine whether individuals harboring a
NOTCH3
cysteine altering variant have a higher load of small vessel disease markers on brain magnetic resonance imaging than controls, as well as a higher risk of stroke and cognitive impairment.

Methods:

A cross-sectional study using integrated clinical, neuroimaging, and whole-exome sequencing data of 92 456 participants from the Geisinger DiscovEHR initiative cohort. The case group consisted of individuals harboring a
NOTCH3
cysteine altering variant (n=118). The control group consisted of randomly selected age- and sex-matched individuals who did not have any nonsynonymous variants in
NOTCH3
(n=184). Medical records including brain magnetic resonance imagings were evaluated for clinical and neuroimaging findings associated with small vessel disease. Group comparisons were done using Fisher exact test and ordinal logistic regression models. Risk of stroke was assessed using Cox regression.

Results:
Of the 118 cases, 39.0% were men, mean age 58.1±16.9 years; 12.6% had a history of stroke, compared with 4.9% of controls. The risk of stroke was significantly increased after age 65 years (hazard ratio, 6.0 [95% CI, 1.4–26.3]). Dementia, mild cognitive impairment, migraine with aura and depression were equally prevalent in cases and controls. Twenty-nine cases (25%) and 45 controls (24%) had an available brain magnetic resonance imaging. After age 65 years, cases had a higher white matter lesion burden and more lacunes. A severe small vessel disease phenotype compatible with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy was rarely seen.

Conclusions:

Cysteine altering
NOTCH3
variants are an important contributor to the risk of stroke, lacunes, and white matter hyperintensities in the elderly population.
Stigmatisation associated with COVID-19 in the general Colombian population
Authors: Cassiani-Miranda Carlos Arturo , Campo-Arias Adalberto , Tirado-Otálvaro Andrés Felipe , Botero-Tobón Luz Adriana , Upegui-Arango Luz Dary , Rodríguez-Verdugo María Soledad , Botero-Tobón María Elena , Arismendy-López Yinneth Andrea , Robles-Fonnegra William Alberto , Niño Levinson , Scoppetta Orlando 
Published: November 2020

Background: As the COVID-19 pandemic progresses, the fear of infection increases and, with it, the stigma-discrimination, which makes it an additional problem of the epidemic. However, studies about stigma associated with coronavirus are scarce worldwide. Aims: To determine the association between stigmatisation and fear of COVID-19 in the general population of Colombia. Method: A cross-sectional study was carried out. A total of 1,687 adults between 18 and 76 years old ( M = 36.3; SD = 12.5), 41.1% health workers, filled out an online questionnaire on Stigma-Discrimination and the COVID-5 Fear Scale, adapted by the research team. Results: The proportion of high fear of COVID-19 was 34.1%; When comparing the affirmative answers to the questionnaire on stigma-discrimination towards COVID-19, it was found that the difference was significantly higher in the general population compared to health workers in most of the questions evaluated, which indicates a high level of stigmatisation in that group. An association between high fear of COVID-19 and stigma was evidenced in 63.6% of the questions in the questionnaire. Conclusion: Stigma-discrimination towards COVID-19 is frequent in the Colombian population and is associated with high levels of fear towards said disease, mainly people who are not health workers.
Contribution of Achilles tendon mechanical properties to torque steadiness in persons with transfemoral amputation
Authors: Toumi Anis , Smart Rowan , Elie Dimitri , Bassement Jennifer , Leteneur Sébastien , Simoneau-Buessinger Emilie , Jakobi Jennifer 
Published: November 2020

Background:
How Achilles tendon mechanics and plantar flexion strength and torque steadiness are altered in the intact leg of persons with trauma-related amputation is unknown. Understanding Achilles tendon mechanics following amputation will further inform rehabilitation approaches to enhance posture, balance, and force control.

Objective:
Conduct a pilot study to quantify plantar flexion maximal voluntary contraction torque, torque steadiness, and Achilles tendon mechanics in persons with unilateral trauma-related transfemoral amputation and controls without amputation.

Study design:
Cross-sectional study.

Methods:
Isometric plantar flexion maximal voluntary contractions were performed with the intact leg of ten males with transfemoral amputation (48 ± 14 years) and the dominant leg of age-matched male controls without amputation. Torque steadiness was calculated as the coefficient of variation in torque over 6 s during submaximal tracking tasks (5%, 10%, 25%, 50%, and 75% maximal voluntary contraction). Achilles tendon elongation and cross-sectional area were recorded with ultrasound to calculate strain, stress, and stiffness.

Results:
Maximal voluntary contraction and torque steadiness did not differ between persons with amputation (90.6 ± 31.6 N m, 3.7 ± 2.0%) and controls (95.8 ± 26.8 N m, 2.9 ± 1.2%; p > 0.05). Tendon stiffness (21.1 ± 18.2 N/mm) and strain (5.2 ± 1.3%) did not differ between groups (p > 0.05). Tendon cross-sectional area was 10% greater in persons with amputation leading to 29% lower stress (p = 0.021). Maximal voluntary contraction was a predictor of a lower coefficient of variation in torque (R
2 = 0.11, p < 0.05).

Conclusion:
Persons with trauma-related transfemoral amputation do not differ in plantar flexion maximal voluntary contraction and torque steadiness of the intact leg compared with controls without amputation. Larger tendon cross-sectional area reduces stress and enables distribution of force across a greater area.
Decreased Sleep Is an Independent Predictor of In-Season Injury in Male Collegiate Basketball Players
Authors: Watson Andrew , Johnson Micah , Sanfilippo Jennifer 
Published: November 2020

Background: Although decreased sleep has been associated with decreased performance, increased illness risk, and impaired well-being in athletes, the relationship between sleep and injury risk in collegiate athletes is unknown. Purpose/Hypothesis: To evaluate the independent effects of sleep duration and subjective well-being on in-season injury in male collegiate basketball athletes. We hypothesized that decreased sleep would be associated with an increased risk of in-season injury. Study Design: Cohort study; Level of evidence, 2. Methods: During 2 consecutive seasons, 19 male National Collegiate Athletic Association Division I basketball players reported mood, fatigue, stress, soreness, sleep duration (hours), and previous day’s training load every morning. Well-being measures were recorded on a scale from 0 (worst) to 5 (best), and all time-loss injuries were recorded by the team athletic trainer. Separate mixed-effects logistic regression models were used to evaluate the effects of sleep and subjective well-being on in-season injury, with adjustment for same-day training load and individual repeated measures. To determine the independence of sleep and well-being as predictors of injury, each well-being variable was included in a separate mixed-effects logistic regression model, with sleep and training load as covariates. Results: During the study period, 32 injuries were recorded. In the initial separate prediction models, in-season injury was significantly predicted by mood (odds ratio [OR], 0.50; 95% CI, 0.37-0.66), fatigue (OR, 0.44; 95% CI, 0.33-0.59), stress (OR, 0.57; 95% CI, 0.42-0.76), soreness (OR, 0.41; 95% CI, 0.32-0.54), and sleep duration (OR, 0.57; 95% CI, 0.49-0.66) ( P < .001 for all). In the multivariable models, sleep duration remained a significant, independent predictor in each of the subsequent multivariable models (OR, 0.52-0.69; P < .001 for all) as did soreness (OR, 0.65; 95% CI, 0.44-0.95; P = .024), whereas mood (OR, 1.2; 95% CI, 0.76-1.9; P = .43), fatigue (OR, 1.1; 95% CI, 0.65-1.9; P = .68), and stress (OR, 1.1; 95% CI, 0.75-1.5; P = .69) were no longer significant. Conclusion: Increased sleep duration is independently associated with a reduced risk of in-season injury in male collegiate basketball players, even after adjustment for training load and subjective well-being. The effects of mood, fatigue, and stress on injury were no longer evident after adjustment for the effect of sleep duration.
Loss of skeletal muscle mass affects the incidence of minimal hepatic encephalopathy: a case control study
Authors: Tateyama Masakuni , Naoe Hideaki , Tanaka Motohiko , Tanaka Kentaro , Narahara Satoshi , Tokunaga Takayuki , Kawasaki Takeshi , Yoshimaru Yoko , Nagaoka Katsuya , Watanabe Takehisa , Setoyama Hiroko , Sasaki Yutaka , Tanaka Yasuhito 
Published: November 2020

Abstract

Background
Sarcopenia is a syndrome characterized by progressive and systemic decreases in skeletal muscle mass and muscle strength. The influence or prognosis of various liver diseases in this condition have been widely investigated, but little is known about whether sarcopenia and/or muscle mass loss are related to minimal hepatic encephalopathy (MHE).

Methods
To clarify the relationship between MHE and sarcopenia and/or muscle mass loss in patients with liver cirrhosis.

Methods
Ninety-nine patients with liver cirrhosis were enrolled. MHE was diagnosed by a neuropsychiatric test. Skeletal mass index (SMI) and Psoas muscle index (PMI) were calculated by dividing skeletal muscle area and psoas muscle area at the third lumbar vertebra by the square of height in meters, respectively, to evaluate muscle volume.

Results
This study enrolled 99 patients (61 males, 38 females). MHE was detected in 48 cases (48.5%) and sarcopenia in 6 cases (6.1%). Patients were divided into two groups, with or without MHE. Comparing groups, no significant differences were seen in serum ammonia concentration or rate of sarcopenia. SMI was smaller in patients with MHE (46.4 cm2/m2) than in those without (51.2 cm2/m2, P = 0.027). Similarly, PMI was smaller in patients with MHE (4.24 cm2/m2) than in those without (5.53 cm2/m2, P = 0.003). Skeletal muscle volume, which is represented by SMI or PMI was a predictive factor related to MHE (SMI ≥ 50 cm2/m2; odds ratio 0.300, P = 0.002, PMI ≥ 4.3 cm2/m2; odds ratio 0.192, P = 0.001).

Conclusions
Muscle mass loss was related to minimal hepatic encephalopathy, although sarcopenia was not. Measurement of muscle mass loss might be useful to predict MHE.
ILCOR’s revised Covid-19 defibrillation recommendation requires a new approach to training
Authors: Stewart John A. 
Published: November 2020

Abstract
In-hospital resuscitation practices have changed by necessity in the Covid-19 era, principally due to precautions intended to protect caregivers from infection. This has resulted in serious delays in resuscitation response.
ILCOR has recently modified its guidelines to separate defibrillation from other interventions, recognizing that shock success is extremely time-dependent and that defibrillation poses relatively little risk of Covid-19 transmission. The new recommendation calls for sending one caregiver into the isolation room in order to initiate bedside monitoring and defibrillate if indicated, while the code team is donning their personal protective equipment. Implementing this change requires focused training in that specific role. This can be accomplished by intensively training a subset of clinical staff to assume the responsibility and act without hesitation when a code occurs.
Focused defibrillation training promises to avoid compromising the care of patients experiencing tachyarrhythmic arrests in the setting of Covid-19. Such a training program might even result in better survival than before the pandemic for this subset of patients.
Whip-LAMP: a novel LAMP assay for the detection of Trichuris muris-derived DNA in stool and urine samples in a murine experimental infection model
Authors: Fernández-Soto Pedro , Fernández-Medina Carlos , Cruz-Fernández Susana , Crego-Vicente Beatriz , Febrer-Sendra Begoña , García-Bernalt Diego Juan , Gorgojo-Galindo Óscar , López-Abán Julio , Vicente Santiago Belén , Muro Álvarez Antonio 
Published: November 2020

Abstract
Background
Trichuris trichiura (human whipworm) infects an estimated 477 million individuals worldwide. In addition to T. trichiura, other Trichuris species can cause an uncommon zoonosis and a number of human cases have been reported. The diagnosis of trichuriasis has relied traditionally on microscopy. Recently, there is an effort to use molecular diagnostic methods, mainly qPCR. LAMP technology could be an alternative for qPCR especially in low-income endemic areas. Trichuris muris, the causative agent of trichuriasis in mice, is of great importance as a model for human trichuriasis. Here, we evaluate the diagnostic utility of a new LAMP assay in an active experimental mouse trichuriasis in parallel with parasitological method by using stool and, for the first time, urine samples.

Methods
Stool and urine samples were collected from mice infected with eggs of T. muris. The dynamics of infection was determined by counting the number of eggs per gram of faeces. A LAMP based on the 18S rRNA gene from T. muris was designed. Sensitivity and specificity of LAMP was tested and compared with PCR. Stool and urine samples were analysed by both LAMP and PCR techniques.

Results
Trichuris muris eggs were detected for the first time in faeces 35 days post-infection. LAMP resulted specific and no cross-reactions were found when using 18 DNA samples from different parasites. The detection limit of the LAMP assay was 2 pg of T. muris DNA. When testing stool samples by LAMP we obtained positive results on day 35 p.i. and urine samples showed amplification results on day 20 p.i., i.e. 15 days before the onset of T. muris eggs in faeces.

Conclusions
To the best of our knowledge, we report, for the first time, a novel LAMP assay (Whip-LAMP) for sensitive detection of T. muris DNA in both stool and urine samples in a well-established mice experimental infection model. Considering the advantages of urine in molecular diagnosis in comparison to stool samples, should make us consider the possibility of starting the use urine specimens in molecular diagnosis and for field-based studies of human trichuriasis where possible. Further studies with clinical samples are still needed.
Acute coronary syndrome with large thrombus successfully managed with no-stenting revascularization based on intravascular imaging in a patient with hyperhomocysteinemia: a case report
Authors: Shoji Keisuke , Yanishi Kenji , Wakana Noriyuki , Nakanishi Naohiko , Zen Kan , Nakamura Takeshi , Shirayama Takeshi , Matoba Satoaki 
Published: November 2020

Abstract

Background
Hyperhomocysteinemia is caused by genetic and environmental factors, which can result in systemic arteriosclerosis and arteriovenous thrombosis including acute coronary syndrome. Thrombus burden in patients with acute coronary syndrome and hyperhomocysteinemia might involve the culprit lesion as compared with those without any coagulopathy. The primary percutaneous coronary intervention with stent implantation had been established as the treatment strategy for patients with acute coronary syndrome. However, in patients with acute coronary syndrome with high thrombus burden or uncontrolled coagulopathy, stent implantation might lead to slow-flow phenomenon or stent thrombosis. Therefore, the treatment strategy in these patients was not established.

Case presentation
A 49-year-old Japanese man with history of splenic infarction of unknown cause had continued anticoagulant therapy since its diagnosis, but stopped taking the medication several months ago. He presented with sudden-onset chest dorsalgia. Contrast computed tomography showed a small pulmonary embolism and his troponin I level was elevated on initial laboratory test. Coronary angiography revealed a contrast defect caused by a large thrombus from the proximal to mid portion of the left anterior descending artery. Near-infrared spectroscopy–intravascular ultrasonography showed a large amount of thrombus without lipid plaque. Therefore, revascularization was performed using a thrombus-aspiration catheter and intracoronary thrombolysis. In addition, , hyperhomocysteinemia and a deep vein thrombosis occurred. He was diagnosed with acute coronary syndrome complicated with pulmonary embolism and deep vein thrombosis simultaneously induced by hyperhomocysteinemia. After 1 week of antithrombotic therapy, near-infrared spectroscopy–intravascular ultrasonography and optical coherence tomography revealed a decreased thrombus and no significant residual organic stenosis in the left anterior descending artery. He continued conservative therapy with antithrombotic medications including aspirin and warfarin and had no cardiovascular events after discharge. Follow-up coronary angiography and optical coherence tomography at 9 months revealed complete disappearance of the thrombus and no severe stenosis.

Conclusions
Hyperhomocysteinemia should be considered as a cause of arterial vein thrombosis of unknown cause. The antithrombotic therapy and percutaneous revascularization without stenting based on intravascular imaging might be a safe and effective treatment option in patients with acute coronary syndrome complicated with hyperhomocysteinemia.
Discovering interlinkages between major cryptocurrencies using high-frequency data: new evidence from COVID-19 pandemic
Authors: Yousaf Imran , Ali Shoaib 
Published: November 2020

Abstract
Through the application of the VAR-AGARCH model to intra-day data for three cryptocurrencies (Bitcoin, Ethereum, and Litecoin), this study examines the return and volatility spillover between these cryptocurrencies during the pre-COVID-19 period and the COVID-19 period. We also estimate the optimal weights, hedge ratios, and hedging effectiveness during both sample periods. We find that the return spillovers vary across the two periods for the Bitcoin–Ethereum, Bitcoin–Litecoin, and Ethereum–Litecoin pairs. However, the volatility transmissions are found to be different during the two sample periods for the Bitcoin–Ethereum and Bitcoin–Litecoin pairs. The constant conditional correlations between all pairs of cryptocurrencies are observed to be higher during the COVID-19 period compared to the pre-COVID-19 period. Based on optimal weights, investors are advised to decrease their investments (a) in Bitcoin for the portfolios of Bitcoin/Ethereum and Bitcoin/Litecoin and (b) in Ethereum for the portfolios of Ethereum/Litecoin during the COVID-19 period. All hedge ratios are found to be higher during the COVID-19 period, implying a higher hedging cost compared to the pre-COVID-19 period. Last, the hedging effectiveness is higher during the COVID-19 period compared to the pre-COVID-19 period. Overall, these findings provide useful information to portfolio managers and policymakers regarding portfolio diversification, hedging, forecasting, and risk management.
Plasma cytokine levels before and 1 year after successful living-donor renal transplantation
Authors: Ito Ayato , Sugimura Jun , Matsuura Tomohiko , Abe Takaya , Obara Wataru 
Published: November 2020

Abstract

Purpose
This study aimed to evaluate cytokine levels in plasma samples over time from living-donor renal transplant recipients with no evidence of pathological and clinical rejection at least 1 year post-procedure.

Methods
We examined plasma cytokine levels in 15 living-donor renal transplant recipients who were treated at our hospital from 2015 to 2018 and who presented with no evidence of pathological or clinical rejection for 1 year or longer. We collected blood samples before renal transplantation and at 1 week and 1 year post-procedure. We evaluated levels of 40 cytokines in plasma using Bio-Plex Pro™ Human Chemokine Assay kit.

Results
We detected no increase in plasma cytokine levels at either the 1 week or the 1 year time points. Plasma levels of 22 cytokines remained stable throughout and levels of 18 cytokine decreased after transplantation.

Conclusion
Plasma cytokine levels remained unchanged or were decreased in our patient cohort that included stable cases of living-donor renal transplantation. Our results suggest that renal transplantation may promote amelioration of chronic inflammation associated with end-stage renal failure and dialysis.