bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic return and volatility spillovers among S&P 500, crude oil, and gold
Authors: Balcilar Mehmet , Ozdemir Zeynel Abidin , Ozdemir Huseyin 
Published: November 2019

AbstractThis article examines the return and volatility spillover effects among the S&P 500, crude oil, and gold by employing the spillover index of Diebold and Yilmaz (2012). Monthly realized volatility and return series covering the period from January 1986 to August 2018 are used to examine the return and volatility spillovers. Our findings indicate a bidirectional return and volatility spillover among these assets. The full sample empirical evidence is consistent with the structure in which oil plays a central role in the information transmission mechanism. The role of oil and gold as a safe haven has changed over time in financial and nonfinancial economic turbulence time‐span. Commodity market financialization has decreased the effectiveness of adding commodities to portfolios after 2002. We find that return spillover is much higher both with considerable negative and positive larger shocks than average shocks, corresponding to left and right tails of the conditional distribution, respectively, while volatility spillover is higher only with positive large shocks than average shocks, which corresponds to shock in the right tail.
A randomized controlled pilot study of ulipristal acetate for abnormal bleeding among women using the 52‐mg levonorgestrel intrauterine system
Authors: Fava Mariana , Peloggia Alessandra , Baccaro Luiz F. , Castro Sara , Carvalho Nelsilene , Bahamondes Luis 
Published: November 2019

AbstractObjectiveTo assess the efficacy of ulipristal acetate (UPA) for reducing abnormal bleeding among women using the 52‐mg levonorgestrel intrauterine system (LNG‐IUS).MethodsA randomized, double‐blind, placebo‐controlled pilot study conducted from September 1, 2016 to September 30, 2018, at the University of Campinas, Brazil. LNG‐IUS users reporting prolonged or frequent uterine bleeding for at least 1 year were randomized to receive 5 mg UPA per day for 5 days or placebo at an identical regimen. Bleeding was recorded for 90 days after treatment began and was compared between the groups.ResultsOf 94 eligible women, 64 with abnormal bleeding associated with LNG‐IUS use declined treatment or device removal after counselling regarding anticipated bleeding patterns. For the 25 study participants, differences were nonsignificant between the UPA and placebo groups for number of days before bleeding stopped and days free of bleeding; however, UPA users displayed a trend for shorter duration before bleeding stopped and longer time free of bleeding. A similar trend for mean number of bleeding days at 30‐, 60‐, and 90‐day follow‐up was observed.ConclusionA nonsignificant trend in reduction of abnormal bleeding was observed among LNG‐IUS users taking 5 mg UPA per day for 5 days compared with placebo; however, further research is needed.ClinicalTrials.gov: NCT03186586
Prophylactic uterine artery embolization during cesarean delivery for placenta previa complicated by placenta accreta
Authors: Yuan Qiang , Jin Yong , Chen Li , Ling Li , Bai Xu‐ming 
Published: November 2019

AbstractObjectiveTo evaluate the efficacy and safety of prophylactic uterine artery embolization (UAE) during cesarean delivery for women with placenta previa complicated by placenta accreta.MethodsA retrospective analysis of women with placenta previa admitted to The Second Affiliated Hospital of Soochow University, Suzhou, China, for elective cesarean between February 2003 and July 2016. Postpartum estimated blood loss, blood transfusion, hysterectomy, disseminated intravascular coagulation (DIC) incidence, intensive care unit (ICU) duration, and postoperative stay were compared between control women who underwent cesarean delivery only and women who underwent prophylactic intraoperative UAE during cesarean.ResultsThere were 28 and 26 women in the UAE and control group, respectively. There were no differences in hysterectomy incidence (P=0.291), or duration of ICU stay (P=0.085), or postoperative hospitalization (P=0.668) between the groups; however, the incidence of DIC was lower in the UAE group (P=0.035). Mean estimated blood loss (P=0.018) and blood transfusion (P=0.011) were also lower in the UAE group. No serious complications were associated with the endovascular procedures.ConclusionProphylactic intraoperative UAE seemed to effectively reduce blood loss, need for blood transfusion, and incidence of DIC among women with placenta previa complicated by placenta accreta.
Nobiletin attenuates acetaminophen‐induced hepatorenal toxicity in rats
Authors: Güvenç Mehmet , Cellat Mustafa , Gökçek İshak , Özkan Hüseyin , Arkalı Gözde , Yakan Akın , Yurdagül Özsoy Şule , Aksakal Mesut 
Published: November 2019

AbstractThe study aimed to examine the effects of nobiletin on the toxicity model induced with acetaminophen (APAP). For this purpose, 24 adult male rats were equally divided into four groups. The groups were the control group (group 1); dimethyl sulfoxide only, the APAP group (group 2) received a single dose of APAP 1000 mg/kg on the 10th day of experiment; the Nobiletin group (group 3), nobiletin (10 mg/kg) for 10 days; and the APAP + Nobiletin group (group 4), nobiletin (10 mg/kg) for 10 days with a single dose of APAP (1000 mg/kg) administered on the 10th day and the experiment ended after 48 hours. At the end of the study, a significant increase in malondialdehyde, interleukin‐1β (IL‐1β), interleukin‐6 (IL‐6), and tumor necrosis factor‐α (TNF‐α) levels and a significant decrease in glutathione levels, glutathione peroxidase activities and nuclear factor erythroid‐derived 2‐like 2 (Nrf‐2) and heme oxygenase‐1 (HO‐1) expressions were observed with APAP application in liver and kidney tissues. Serum aspartate transaminase (AST), alanine transaminase (ALT), urea, and creatinine levels were also significantly increased in the APAP group. However, nobiletin treatment in group 4 reversed oxidative stress and inflammatory and histopathological signs caused by APAP. It is concluded that nobiletin may be a beneficial substance that confers hepatorenal protection to APAP‐induced toxicity via antioxidant and anti‐inflammatory mechanisms.
Computational insight into energetic cage derivatives based on hexahydro‐1,3,5‐trinitro‐1,3,5‐triazine
Authors: Wang Kun , Zhu Simin , Wu Xiaowei , Zhu Weihua 
Published: November 2019

AbstractFour novel cage compounds were designed by introducing –N(NO2)CH2–, –N(NO2)O–, –N(NO2)N(NO2)–, and –N=N– linkages into the RDX (hexahydro‐1,3,5‐trinitro‐1,3,5‐triazine) skeleton. Their molecular geometry, electronic structure, heat of formation, and detonation properties were systematically studied using density functional theory (DFT). In addition, the most stable dimers of the four compounds were constructed to further investigate their stability based on intermolecular interactions. It is found that the unconventional CH⋯O interactions would be the dominant driving force when the title compounds form crystals. Compared with the traditional explosives, the compounds with higher detonation properties and lower impact sensitivity will be considered as promising candidates for high energy density compounds. Our results indicate that our innovative design strategy is extremely useful for developing novel energetic compounds.
The role of resources in the face of psychopathology
Authors: Goldbach Nele , Reif Andreas , Preuss Hanna , Röhm Mira , Straus Eva , Streicher Elisabeth , Windmann Sabine , Oertel Viola 
Published: November 2019

AbstractObjectivesThe current study compared resource realization and psychological distress in patients with different psychiatric diagnoses and healthy individuals and examined the moderating effect of intrapersonal resources (personal strengths) and interpersonal resources (relationships) on the association between incongruence (unsatisfactory realization of personal goals) and psychological distress.MethodIn total, 218 participants (45.87% female, mean age = 39.83 years) completed standardized questionnaires at one measurement point.ResultsHealthy individuals (n = 56) reported the most resources, followed by patients with psychotic (n = 53), substance use (n = 53), and depressive disorders (n = 56). While patients with psychotic disorders benefited from intra‐ and interpersonal resources, patients with depression only benefitted from intrapersonal resources. Patients with substance use disorders did not benefit from resources at all.ConclusionsDepending on the diagnosis, patients evaluated their level of resources differently and benefitted in different ways. The results suggest that within psychotherapy, it might be useful to strengthen resources, especially for patients with depressive and substance use disorders.
A quest for self‐soothing: A systematic case study into emotion‐focused therapy with an emotionally avoidant client who committed sexual offenses
Authors: Gunst Ellen , Watson Jeanne , Willemsen Jochem , Desmet Mattias , Loeys Tom , Vanhooren Siebrecht 
Published: November 2019

AbstractObjectiveThe current study is part of a multiple case study that investigated the emotional change in individuals who have committed sexual offenses (ISOs). This case study highlights how one client used sex as a maladaptive coping strategy to suppress negative emotions.MethodA mixed‐methods design was used to track changes in the client's affect regulation (AR) during four phases, including a baseline (Phase A), treatment as usual (Phase B), treatment with an emotion‐focused therapy (EFT) component added (Phase C), and follow up (Phase A).ResultsThe qualitative description with verbatim clinical vignettes, revealed deeper insight into some important steps and hindrances and the impact of specific EFT‐interventions. Quantitative analysis of self‐report and observational measures showed a significant improvement in the client's AR across different phases of treatment.ConclusionsThe study improves our knowledge of the emotional change in ISOs during treatment and illustrates some key interventions, steps, and hindrances.
The resilience of Peruvian immigrants through participation in community‐based organizations in urban Chile
Authors: Marzana Daniela , Martinez Damia Sara , Atallah Devin , Loreto Martinez Maria 
Published: November 2019

AbstractThis study explores the situational elements related to the resilience of Peruvian immigrants in Santiago, Chile. Through extensive fieldwork with Santiago community‐based organizations, in‐depth semistructured interviews (N = 18) completed with Peruvian leaders, and an innovative grounded theory situational analysis, a critical psychopolitical framework of community participation of Peruvian immigrants was generated. More specifically, three main themes emerged from data analysis and describe resilience processes, including, negotiating historical narratives and multiple identities; navigating to resources; and resisting racism and dehumanization. Results describe how community participation plays a role in promoting resilience by transforming immigrants' conditions and contexts while increasing their sense of mattering, and their access to resources and human rights.
Pharmacokinetics of Patisiran, the First Approved RNA Interference Therapy in Patients With Hereditary Transthyretin‐Mediated Amyloidosis
Authors: Zhang Xiaoping , Goel Varun , Robbie Gabriel J. 
Published: November 2019

AbstractHereditary transthyretin‐mediated (hATTR) amyloidosis is a rare, inherited, progressively debilitating, and often fatal disease caused by deposition of mutated transthyretin (TTR) protein. Patisiran is an RNA interference therapeutic comprising a novel small interfering ribonucleic acid (ALN‐18328) formulated with 2 novel lipid excipients, DLin‐MC3‐DMA and PEG2000‐C‐DMG, in a lipid nanoparticle targeted to inhibit hepatic TTR synthesis. Here we report the pharmacokinetics (PK) of ALN‐18328, DLin‐MC3‐DMA, and PEG2000‐C‐DMG from a phase 2 multiple‐ascending‐dose study and its open‐label extension (OLE) in patients with hATTR amyloidosis. Twenty‐nine patients received 2 intravenous infusions of patisiran of 0.01, 0.05, 0.15, or 0.3 mg/kg at 3‐ or 4‐week intervals; of these, 27 patients received 0.3 mg/kg once every 3 weeks over 24 months in the OLE study. Plasma PK profiles of ALN‐18328 and DLin‐MC3‐DMA exhibited 2 phases, the first characterized by a short distribution half‐life and the second by a minor peak and relatively long terminal elimination half‐life. PK exposures to 3 analytes increased proportionally across the dose range of 0.01 to 0.3 mg/kg. For ALN‐18328, mean terminal elimination half‐life was 3.2 days, mean total clearance was 3.0 mL/h/kg, and urinary excretion was negligible. All 3 analytes exhibited stable PK profiles with chronic dosing over 2 years. The 2‐ to 3‐fold plasma accumulation (AUCτ) of ALN‐18328 at steady state is attributable to the association of ALN‐18328 with the cationic lipid DLin‐MC3‐DMA. There was no appreciable accumulation of PEG2000‐C‐DMG.
A simple and sensitive hydrogen peroxide detection with horseradish peroxidase immobilized on pyrene modified acid‐treated single‐walled carbon nanotubes
Authors: Şahin Samet 
Published: November 2019

AbstractBACKGROUNDHydrogen peroxide (H2O2) plays an essential role in different reactions and mechanisms. Therefore, simple and sensitive detection of H2O2 becomes very important for both medical and environmental applications.RESULTSTwo‐step immobilization of horseradish peroxidase (HRP) on acid‐treated single‐walled carbon nanotubes (cut‐SWCNTs) was reported for the sensitive detection of H2O2 at physiological conditions. Cut‐SWCNTs were first synthesized using acid treatment and then coated onto screen‐printed electrodes (SPEs) for electrochemical optimization tests. Electrochemical characterization of cut‐SWCNTs coated CSPEs showed a linear relationship between current and increasing material loading. Also, the films demonstrated good reproducibility and stability. Immobilization of HRP was then achieved successfully using pyrene crosslinking chemistry on cut‐SWCNT coated SPEs. The detection of H2O2 was achieved with HRP/cut‐SWCNT/SPE electrode configuration using voltammetry technique. The constructed biosensor has sensitivity and apparent Michaelis–Menten constant (Km) values of 34.1 μA L mmol–1 cm−2 and 0.47 mmol L–1, respectively within the linear range of 20 to 600 μmol L–1 H2O2 concentration. The biosensor also showed a good degree of reproducibility and low cross‐contamination for tested interferences.CONCLUSIONH2O2 biosensor was successfully developed using cut‐SWCNTs and HRP enzyme establishing successful direct electrochemical communication between the enzyme and electrode using pyrene crosslinking chemistry. This study suggests that developed biosensors could be promising for H2O2 detection in medical and environmental applications. © 2019 Society of Chemical Industry
Bovine aortic arch: Prevalence in human fetuses
Authors: Goldsher Yulia W. , Salem Yishai , Weisz Boaz , Achiron Reuven , Jacobson Jeffrey M. , Gindes Liat 
Published: November 2019

AbstractObjective“Bovine aortic arch” is the second most common variant of aortic arch branching, in which only two branches originate directly from the aorta. The prevalence of this condition has been reported in different studies to be around 6% in human fetuses and 11‐27% in the adult population. In this study, we describe the prevalence of bovine aortic arch in fetuses, and assess the prevalence of concomitant fetal anomalies.MethodsA retrospective analysis of 417 fetuses between 15‐40 weeks of gestation. Data regarding branching of the fetal aortic arch and other fetal anomalies were collected by fetal echocardiography and/or fetal ultrasonography.ResultsA bovine arch was found in 20/413 fetuses (4.8%, 95CI 3.1‐7.3%), of whom 14/310 (4.5%) had no fetal anomalies, and 6/77 (7.8%) exhibited minor changes (P = .241). None of the 26 fetuses with major anomalies had a bovine arch.ConclusionFetuses in this study had a lower prevalence of bovine aortic arch than that previously reported in adults, most probably due to differences in the population examined. This study was underpowered to determine that bovine arch is a common anatomic variant, and is not associated with fetal anomalies.
Hamiltonian cycles in k‐partite graphs
Authors: DeBiasio Louis , Krueger Robert A. , Pritikin Dan , Thompson Eli 
Published: November 2019

AbstractChen et al determined the minimum degree threshold for which a balanced ‐partite graph has a Hamiltonian cycle. We give an asymptotically tight minimum degree condition for Hamiltonian cycles in arbitrary ‐partite graphs in that all parts have at most vertices (a necessary condition). To do this, we first prove a general result that both simplifies the process of checking whether a graph is a robust expander and gives useful structural information in the case when is not a robust expander. Then we use this result to prove that any ‐partite graph satisfying the minimum degree condition is either a robust expander or else contains a Hamiltonian cycle directly.
The extremal function for K9= minors
Authors: Rolek Martin 
Published: November 2019

AbstractWe prove the extremal function for minors, where denotes the complete graph with two edges removed. In particular, we show that any graph with vertices and at least edges either contains a minor or is isomorphic to a graph obtained from disjoint copies of and by identifying cliques of size 5. We utilize computer assistance to prove one of our lemmas.
Hamiltonian cycles in 3‐tough 2K2‐free graphs
Authors: Shan Songling 
Published: November 2019

AbstractA graph is called ‐free if it does not contain two independent edges as an induced subgraph. Broersma, Patel, and Pyatkin showed that every 25‐tough ‐free graph with at least three vertices is Hamiltonian. In this paper, we improve the required toughness in this result from 25 to 3.
Therapeutic potential of triheptanoin in metabolic and neurodegenerative diseases
Authors: Wehbe Zeinab , Tucci Sara 
Published: November 2019

AbstractIn the past 15 years the potential of triheptanoin for the treatment of several human diseases in the area of clinical nutrition has grown considerably. Use of this triglyceride of the odd‐chain fatty acid heptanoate has been proposed and applied for the treatment of several conditions in which the energy supply from citric acid cycle intermediates or fatty acid degradation are impaired. Neurological diseases due to disturbed glucose metabolism or metabolic diseases associated with impaired β‐oxidation of long chain fatty acid may especially take advantage of alternative substrate sources offered by the secondary metabolites of triheptanoin. Epilepsy due to deficiency of the GLUT1 transporter, as well as diseases associated with dysregulation of neuronal signalling, have been treated with triheptanoin supplementation, and very recently the advantages of this oil in long‐chain fatty acid oxidation disorders have been reported. The present review summarises the published literature on the metabolism of triheptanoin including clinical reports related to the use of triheptanoin.
Sensitivity of climate models in relation to the “pool of inhibited cloudiness” over South of the Bay of Bengal
Authors: Roy Kumar , Mukhopadhyay Parthasarathi , Murali Krishna Ravuri Phani , Ganai Malay , Mahakur Mata , Narayana Rao Thota , Nair Anish Kumar M. , Ramakrishna Surireddi Satya Venkata Siva 
Published: November 2019

AbstractRealistic simulation of cloud variability and rainfall by the coupled models still remains a challenge particularly over the Asian Summer Monsoon (ASM). The simulation of the “pool of inhibited cloudiness” (hereafter referred to as PIC) and associated cloud variability have been analysed in the historical run of 26 models which participated in the Coupled Model Intercomparison Project Phase 5 (CMIP5) and it is shown that the current state of the art general circulation models (GCMs) still have difficulties in properly simulating the PIC. The pool covers an area greater than 1 million km2 between 3°–13°N and 77°–90°E over the southwest Bay of Bengal (BoB); persisting throughout the ASM and interestingly it is surrounded by the deep convective region. The majority of the models could not simulate cloud variability over the ASM. The performance of National Centre for Environmental Prediction (NCEP) Climate Forecast System (CFSv2) version 2.0, which is being used for operational monsoon prediction over the Indian region, is also tested to evaluate its fidelity in capturing PIC. The moist convective process in the default CFSv2 is found to be one of the major sources of uncertainty in its monsoon prediction. In this study, evaluation of the default CFSv2 (CTRL) and suites of modified CFSv2 have been carried out. The default version of CFSv2 has the simplified Arakawa Schubert (SAS) as convection scheme and Zhao and Carr (ZC) as microphysics. In another modification, the SAS is changed to revised simplified Arakawa Schubert (RSAS) keeping the microphysics unchanged. Further, a more physically based cloud scheme (WRF Single Moment 6‐class microphysics—WSM6) is used with SAS and RSAS for comparison of simulation of PIC. Among the CMIP5 models, ACESS‐1‐0, GFDL‐CM3, HadGEM2‐CC, HadGEM2‐ES are able to represent the PIC reasonably well. CFSCR has shown an improved fidelity in comparison to the CTRL, CTRL‐WSM and RSAS and other CMIP5 models. The impact of cloud microphysics in CTRL‐WSM and CFSCR appears to play an important role in the simulation of the PIC.
Inconsistent aerosol indirect effects on water clouds and ice clouds over the Tibetan Plateau
Authors: Hua Shan , Liu Yuzhi , Luo Run , Shao Tianbin , Zhu Qingzhe 
Published: November 2019

AbstractRecently, satellites have observed that dust events are occurring more frequently over the Tibetan Plateau (TP), which implies a new issue of aerosols influencing cloud properties and presents a new challenge in research on the role of the TP in climate change. In this study, combining satellite observations with Climate Model Intercomparison Project Phase 5 (CMIP5) model simulations, the inconsistent aerosol indirect effects on the properties of water clouds and ice clouds over the TP are compared and quantified. Analyses of satellite observations show that, compared with water clouds, ice clouds are observed more frequently and are more significantly correlated with aerosols over the TP. Correspondingly, the aerosol effect on the radiative forcing of ice clouds is more significant than that on the forcing of water clouds, in which the aerosol indirect effect is dominated by the effect on the shortwave radiative forcing of ice clouds. Both observations and CMIP5 model simulation results show that, due to the variation of aerosols, changes in the ice cloud radiative forcing cover most of the TP, while changes in the water cloud radiative forcing mainly appear over the southern edge of the TP. The CMIP5 simulation results suggest that the aerosol indirect effect on the total radiative forcing of water clouds over the TP is −0.34 (±0.03) W⋅m−2, while that on the forcing of ice clouds is −0.73 (±0.03) W⋅m−2. Overall, both the model simulations and satellite results show that the indirect effect of aerosols on ice clouds is more pronounced than that on water clouds.