bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental Investigation of Inclined Circular Ring Turbulators on Heat Transfer and Fluid Flow Characteristics
Authors: Suryavanshi Atul M. , Kamble Avinash G. , Kore Sandeep S. 
Published: December 2020

Abstract
This paper demonstrates influence of various inclination of Circular Ring Turbulator (CRT) on thermal characteristics in circular type heat exchanger. “A wall linked circular inserts were analyzed having constant inner diameter to achieve uniform flow blockage area (FBA) of 40%”. These CRTs located within the tube to prevailed different angular patterns (-10°, -15°, - 20° and -25°) w. r. t. horizontal of tube. Influence of these geometries on fluid friction and heat performance were studied. Parameter constant throughout the investigation was diameter ratio and Pitch Diameter Ratio (PDR). Modified parameters throughout study were the angular inclinations of CRT and Reynolds number. Inner side of tube is preserved at constant heat flux having air as working medium at atmospheric temperature with variation of Reynolds number from 6,000 to 24,000 respectively.
Implementation of CRT as turbulator favorably improves rate of heat exchange within heated enclosure of tube to fluid domain throughout the test model. Out of all studied inserts, CRT having angular deflection of -25° gives peak value of heat transfer at extreme Reynolds number and at slightest Reynolds number CRT having angle inclination of -10° offers greater friction factor which is at 2.5 and 5.5 times than smooth tube. CRT with angular inclination of -25° at minimum Reynolds number offers extreme thermal performance factor is 1.7.
Improvement of Weld Joint Strength by Applying Random Vibrations Along With External Magnetic Field
Authors: Chitturi Suresh , Mohana Krishna Chowdary K , Bhaumik Munmun , Ammisetti Dhanunjay Kumar 
Published: December 2020

Abstract
Welding is a metal joining process induces high residual stresses. These are strongly influencing the mechanical properties of weldment. In earlier days heat treatment and shot peening techniques were used to relieve these stresses. Due to the time consuming of these processes, in this research work we have applied random vibrations to relive the residual stresses to improve mechanical properties. Along with that, welding arc may get affected by magnetic field during welding. This leads to arc instability which is responsible for welding defects like lack of fusion, porosity. These reduce the quality and strength of weld. To overcome this, arc spattering with external magnetic field need to be reduced. In this research work, a setup has been designed for vibration assisted welding along with external magnetic field set up to improve the mechanical properties of Mild Steel weld joints by means of hardness and ultimate tensile strength. Welding had been performed with and without these setups. After performing welding work pieces have been tested both welding conditions and results have been compared.
Effect of Higher Transition Foundation on Dynamic Stability Boundaries of Simply Supported Beam
Authors: Subbaratnam B. , Jalagam Ravinder Rao , Jena Shakti Prasanna , Gupta M. Satyanarayana 
Published: December 2020

Abstract
Accurate closed form solution to predict the dynamic stability behavior of simply supported (SS) beam on elastic foundation, subjected to an end axial periodic load, has been derived using simple single term trigonometric function which satisfies the geometric boundary conditions. The effect of higher transition foundation on dynamic stability regions is studied. The energy method is used in the present work to evaluate the dynamic stability boundaries. Euler - Bernoulli beam theory is used for the analysis. Numerical results are presented using proper non-dimensional parameters with varying foundation parameters below and above the second transition foundation value of elastic foundation, in both the digital and analogue forms for better comprehension of the dynamic stability behavior of the beams. The effect of the higher transition foundation value of the elastic foundation on the dynamic stability behavior is brought out in the present work.
Multi-Criteria Optimization of Aerospace Alloys in WEDM Using TOPSIS
Authors: Heralge Sanjay , Gupta Umashanker , Dabir Jamil 
Published: December 2020

Abstract
Wire EDM is commonly used for machining of complex profiles in hard and exotic materials. In the present work the key performance of Wire EDM such as wire cutting speed, surface roughness and cut width in machining of three different aerospace class materials such as near beta titanium alloy, forged nickel base alloy and aged aluminum alloy are studied. Apart from electrical parameters, the wire with zinc coated brass and plain brass are used. TOPSIS (Technique for Order Preference by Similarity to Ideal Solution) is the Multi-Criteria Decision-Making method used for selecting the best setting of control parameters. Parameter sets are ranked from best to worst based on the performance score. Zinc coated wire outperforms the brass wire almost for every response variable in case of Ni and Ti alloy while with Al it is as good as plain wire.
Model and Material Analysis of Gokart Chassis
Authors: Ramana Reddy D.V. , Kumar G. Revanth 
Published: December 2020

Abstract
The present study of this paper is to select the best material for manufacturing the Go-Kart. To meet this designing of go-kart chassis done by using CAD software CATIA tool and simulate with ANSYS work-bench. To select the best material, strength to weight ratio plays major role on it. Steel is considering to existing material another two materials Aluminum-6061, Kevlar selected. The main reason behind choosing Aluminum-6061, Kevlar materials is two materials are having less density and high yield limit values, and this factor can increase the strength/weight ratio compare to existing material steel. In this project material selection is one of the main design decisions that greatly increase the safety, reliability and performance. The material selection is choosen after my extensive research with various parameters like strength, weight and cost. We are comparing Aluminum-6061and Kevlar materials with mild steel. In this process boundary conditions applied on each material and calculated results like deformation, stress, strain, safety factor, natural frequency values, by knowing all these results, concluded with optimum material.
Performance of Fly Ash and Ggbs Based Geopolymer Concrete Using Single Alkaline Activator Solution and Its Cost Analysis
Authors: Rao G. Mallikarjuna , Kumar Y. Anil , Vengala Jagadish , Venu M. 
Published: December 2020

Abstract
Concrete is the most durable, versatile and reliable building material in the world. Next to water, concrete is the most used material. Ordinary Portland cement production accounts for 5-7% of total greenhous e gas emissions. It also consumes a lot of energy. Today, Geo-polymer concrete (GPC) has become a more sustainable concrete compared to conventional concrete. This research work focuses on the performance of Fly Ash and GGBS based geo-polymer concrete cured in outdoor conditions using a single alkaline activator solution (Geo activator). The variations of Fly Ash and GGBS were (FA100-GGBS0; FA90- GGBS10; FA70-GGBS30; FA50-GGBS50). In this study, only the Geo activator is used to activate Fly Ash and GGBS in the mixtures. Geo polymer concrete of size 100 mm x 100 mm x 100 mm was used in this research work to measure compressive strength at different ages of 7 days and 28 days. The results reveal that the increase in the proportion of GGBS content in the mix increases compression strength of concrete. The cost analysis was also carried for geopolymer concrete, compared with conventional concrete and the results reveals that for the lower grades, the cost will be the same as for conventional concrete and for the higher grades, the use of geo polymer concrete can reduce the cost of construction up to some extent.
Transient chaos in time-delayed systems subjected to parameter drift
Authors: Cantisán Julia , Seoane Jesús M , Sanjuán Miguel A F 
Published: December 2020

Abstract
External and internal factors may cause a system’s parameter to vary with time before it stabilizes. This drift induces a regime shift when the parameter crosses a bifurcation. Here, we study the case of an infinite dimensional system: a time-delayed oscillator whose time delay varies at a small but non-negligible rate. Our research shows that due to this parameter drift, trajectories from a chaotic attractor tip to other states with a certain probability. This causes the appearance of the phenomenon of transient chaos. By using an ensemble approach, we find a gamma distribution of transient lifetimes, unlike in other non-delayed systems where normal distributions have been found to govern the process. Furthermore, we analyze how the parameter change rate influences the tipping probability, and we derive a scaling law relating the parameter value for which the tipping takes place and the lifetime of the transient chaos with the parameter change rate.
Endotoxin for Alcohol Research: A Call for Experimental Medicine Using Lipopolysaccharide Challenge
Authors: Burnette Elizabeth M , Grodin Erica N , Eisenberger Naomi I , Ray Lara A 
Published: December 2020

Abstract
Studies of inflammation in alcohol use disorder (AUD) are overwhelmingly preclinical, and translation to clinical samples is necessary. Endotoxin administration has been used successfully in humans to study mood disorders, offering a translational, reliable and safe model that may be validated in AUD research. We argue for the use of endotoxin challenge to elucidate the interplay between AUD and inflammation.
Recognition of small molecule–RNA binding sites using RNA sequence and structure
Authors: Su Hong , Peng Zhenling , Yang Jianyi 
Published: December 2020

Abstract

Motivation
RNA molecules become attractive small molecule drug targets to treat disease in recent years. Computer-aided drug design can be facilitated by detecting the RNA sites that bind small molecules. However, very limited progress has been reported for the prediction of small molecule–RNA binding sites.

Results
We developed a novel method RNAsite to predict small molecule–RNA binding sites using sequence profile- and structure-based descriptors. RNAsite was shown to be competitive with the state-of-the-art methods on the experimental structures of two independent test sets. When predicted structure models were used, RNAsite outperforms other methods by a large margin. The possibility of improving RNAsite by geometry-based binding pocket detection was investigated. The influence of RNA structure’s flexibility and the conformational changes caused by ligand binding on RNAsite were also discussed. RNAsite is anticipated to be a useful tool for the design of RNA-targeting small molecule drugs.

Availability and implementation
http://yanglab.nankai.edu.cn/RNAsite.

Supplementary information
Supplementary data are available at Bioinformatics online.
shinyÉPICo: a graphical pipeline to analyze Illumina DNA methylation arrays
Authors: Morante-Palacios Octavio , Ballestar Esteban 
Published: December 2020

Abstract

Summary
Illumina DNA methylation bead arrays provide a cost-effective platform for the simultaneous analysis of a high number of human samples. However, the analysis can be time-demanding and requires some computational expertise. shinyÉPICo is an interactive, web-based, and graphical tool that allows the user to analyze Illumina DNA methylation arrays (450k and EPIC), from the user’s own computer or from a server. The tool covers the entire analysis, from the raw data to the final list of differentially methylated positions and differentially methylated regions between sample groups. It allows the user to test several normalization methods, linear model parameters, including covariates, and differentially methylated CpGs filters, in a quick and easy manner, with interactive graphics helping to select the options in each step. shinyÉPICo represents a comprehensive tool for standardizing and accelerating DNA methylation analysis, as well as optimizing computational resources in laboratories studying DNA methylation.

Availability and implementation
shinyÉPICo is freely available as an R package at the Bioconductor project (http://bioconductor.org/packages/shinyepico/) and GitHub (https://github.com/omorante/shinyepico) under an AGPL3 license.
Working with Incarcerated Youth: Emotional Labour and Moral Wages
Authors: Perry Kelsea , Ricciardelli Rosemary 
Published: December 2020

AbstractPrisons are increasingly recognized as emotional places, especially for frontline staff. Though sociological accounts of emotional labour in prisons acknowledges the potential for negative outcomes (e.g. burnout), little scholarly attention has investigated the potential for positive outcomes, particularly opportunities for staff to earn moral wages. This article explores the emotional labour undertaken by correctional officers (COs) working with incarcerated youth in Canadian provincial prisons. Utilizing interviews with 40 COs, we unpack the patterned interactions characteristic of frontline work that call for emotional labour by prison staff, and its outcomes. Our results show that staff are aware of the emotional labour expected of them on the frontline, where opportunities to earn moral wages are contextualized by structural limitations inherent to the carceral environment.
A novel approach for monitoring TGF-β signaling in vivo in colon cancer
Authors: Zhang Bin-hao , Wang Chao , Dong Wei , Chen Xin , Leng Chao , Luo Xin , Dong Shui-lin , Yin Ping , Zhang Bi-xiang , Datta Pran K , Chen Xiao-ping 
Published: December 2020

Abstract
The TGF-β receptor kinase inhibitors (TRKI) have been reported to inhibit tumorigenicity in colon cancer. However, there is no direct evidence showing that these inhibitors function through inhibiting the TGF-β- mediated tumor-promoting effects in vivo. We established a TGF-β inducible reporter system by inserting a luciferase reporter gene to the vector downstream of TGF-β-inducible promoter elements, and transfected it into colon cancer cell lines. TRKIs SB431542 and LY2109761 were used to treat TGF-β inducible cells in vitro and in vivo. The luciferase activity was induced 5.24-fold by TGF-β in CT26 inducible cells, while it was marginally changed in MC38 inducible cells lacking Smad4 expression. Temporary treatment of mice with SB431542 inhibited the TGF-β pathway and TGF-β induced bioluminescence activity in vivo. Long-term treatment with LY2109761 inhibited tumorigenicity and liver metastasis in vivo in concomitant with reduced luciferase activity in the tumor. In this study, we established a model to monitor the TGF-β pathway in vivo and to compare the antitumor effects of TRKIs. Based on this novel experimental tool, we provided direct evidences that LY2109761 inhibits tumorigenicity and liver metastasis by blocking the pro-oncogenic functions of TGF-β in vivo.
Endoscopic vacuum therapy for anastomotic leak after esophagectomy: a single-center’s early experience
Authors: Hayami Masaru , Klevebro Fredrik , Tsekrekos Andrianos , Samola Winnberg Johanna , Kamiya Satoshi , Rouvelas Ioannis , Nilsson Magnus , Lindblad Mats 
Published: December 2020

Summary
Anastomotic leak is a serious complication after esophagectomy. Endoscopic vacuum therapy (EVT) has become increasingly popular in treating upper gastrointestinal anastomotic leaks over the last years. We are here reporting our current complete experience with EVT as primary treatment for anastomotic leak following esophagectomy. This is a retrospective study analyzing all patients with EVT as primary treatment for anastomotic leak after esophagectomy between November 2016 and January 2020 at Karolinska University Hospital, Sweden. The primary endpoint was anastomotic fistula healing with EVT only. Twenty-three patients primarily treated with EVT after anastomotic leak following esophagectomy were included. Median duration of EVT was 17 days (range 5–56) with a median number of 3 (range 1–14) vacuum sponge changes per patient. A total number of 95 vacuum sponges were placed in the entire cohort, of which 93 (97.9%) were placed intraluminally and 2 (2.1%) extraluminally. The median changing time interval of sponges was 5 days (range 2–8). Successful fistula healing was achieved in 19 of 23 patients (82.6%), of which 17 (73.9%) fistulas healed with EVT only. There were 2 (8.7%) airway fistulas following EVT. No other adverse events occurred. Three patients (13%) died in-hospital. In conclusion EVT seems to be a safe and feasible therapy option for anastomotic leak following esophagectomy. The effect of EVT on the risk for development of airway fistulas needs to be addressed in future studies and until more data are available care should be taken regarding sponge positioning as well as extended treatment duration.
Impact of the COVID-19 pandemic: a perspective from industry
Authors: West Nick E. J. , Cheong Wai-Fung , Boone Els , Moat Neil E. 
Published: December 2020

Abstract
The global COVID-19 pandemic has led to unprecedented change throughout society.1 As the articles in this supplement outline, all segments of the broader cardiovascular community have been forced to adapt, to change models of care delivery, and to evolve and innovate in order to deliver optimal management for cardiovascular patients. The medtech/device industry has not been exempt from such change and has been forced to navigate direct and indirect COVID-associated disruption, with effects felt from supply chain logistics to the entire product lifecycle, from the running of clinical trials to new device approvals and managing training, proctoring and congresses in an increasingly-online world.
This sea-change in circumstances itself has enforced the industry, in effect, to disrupt its own processes, models and activities. Whilst some of these changes may be temporary, many will endure for some time and some will doubtless become permanent; one thing is for sure: the healthcare ecosystem, including the medical device industry, will never look quite the same again. Although the pandemic has brought a short- to medium-term medical crisis to many countries, its role as a powerful disruptor cannot be underestimated, and may indeed prove to be a force for long-term good, given the accelerated innovation and rapid adaptation that it has cultivated.
Is This Phishing? Older Age Is Associated With Greater Difficulty Discriminating Between Safe and Malicious Emails
Authors: Grilli Matthew D , McVeigh Katelyn S , Hakim Ziad M , Wank Aubrey A , Getz Sarah J , Levin Bonnie E , Ebner Natalie C , Wilson Robert C 
Published: December 2020

Abstract

Objectives
As our social worlds become increasingly digitally connected, so too has concern about older adults falling victim to “phishing” emails, which attempt to deceive a person into identity theft and fraud. In the present study, we investigated whether older age is associated with differences in perceived suspiciousness of phishing emails.

Methods
Sixty-five cognitively normal middle-aged to older adults rated a series of genuine and phishing emails on a scale from definitely safe to definitely suspicious.

Results
Although older age was not related to a shift in overall perception of email safety, older age was related to worse discrimination between genuine and phishing emails, according to perceived suspiciousness.

Discussion
These findings suggest that cognitively normal older adults may be at particular risk for online fraud because of an age-associated reduction in their sensitivity to the credibility of emails.
Photon-magnon response to fluid variability and saturation levels in sandstone reservoirs
Authors: Ali Abdullah Musa , Rostami Amir , Yahya Noorhana 
Published: December 2020

Abstract
The need to recover high viscosity heavy oil from the residual phase of reservoirs has raised interest in the use of electromagnetics (EM) for enhanced oil recovery. However, the transformation of EM wave properties must be taken into consideration with respect to the dynamic interaction between fluid and solid phases. Consequently, this study discretises EM wave interaction with heterogeneous porous media (sandstones) under different fluid saturations (oil and water) to aid the monitoring of fluid mobility and activation of magnetic nanofluid in the reservoir. To achieve this aim, this study defined the various EM responses and signatures for brine and oil saturation and fluid saturation levels. A Nanofluid Electromagnetic Injection System (NES) was deployed for a fluid injection/core-flooding experiment. Inductance, resistance and capacitance (LRC) were recorded as the different fluids were injected into a 1.0-m long Berea core, starting from brine imbibition to oil saturation, brine flooding and eventually magnetite nanofluid flooding. The fluid mobility was monitored using a fibre Bragg grating sensor. The experimental measurements of the relative permittivity of the Berea sandstone core (with embedded detectors) saturated with brine, oil and magnetite nanofluid were given in the frequency band of 200 kHz. The behaviour of relative permittivity and attenuation of the EM wave was observed to be convolutedly dependent on the sandstone saturation history. The fibre Bragg Grating (FBG) sensor was able to detect the interaction of the Fe3O4 nanofluid with the magnetic field, which underpins the fluid mobility fundamentals that resulted in an anomalous response.
The role of radiotherapy in the age of immunotherapy
Authors: Sato Hiro , Demaria Sandra , Ohno Tatsuya 
Published: December 2020

Abstract
With the development of immune checkpoint inhibitors, the efficacy of immunotherapy as a cancer treatment that is effective against multiple tumor types has been established, and this modality came to be considered as the fourth pillar of cancer therapy. The clinical success of immunotherapy greatly changed the field of oncology by highlighting the importance of the immune system in cancer control and elimination. It has now become clear that research into, and the clinical application of, the immune response are important for effective cancer treatment. Moreover, it has become apparent that conventional cancer treatments, such as radiotherapy and chemotherapy, can modulate the cross-talk between the tumor and the immune system, and their efficacy depends, in part, on the ability to elicit antitumor immune response. The ability of radiotherapy to induce an immune response has become relevant in the immunotherapy age. Radiotherapy has been redefined as a partner for cancer immunotherapy, based on evidence indicating the potential synergistic effect of the combination of these therapeutic modalities. This review outlines the major findings reported to date on the immune response induced by radiotherapy and discusses the role of radiotherapy in combination with immunotherapy. Furthermore, we introduce research aimed at the clinical application of combination therapy and discuss its potential in clinical practice and future issues.