bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acetylation of conserved lysines fine-tune mitochondrial malate dehydrogenase activity in land plants
Authors: Balparda Manuel , Elsässer Marlene , Badia Mariana B. , Giese Jonas , Bovdilova Anastassia , Hüdig Meike , Reinmuth Lisa , Schwarzländer Markus , Finkemeier Iris , Schallenberg-Rüdinger Mareike , Maurino Veronica G. 
Published: October 2020

AbstractPlants need to rapidly and flexibly adjust their metabolism to changes of their immediate environment. Since this necessity results from the sessile lifestyle of land plants, key mechanisms for orchestrating central metabolic acclimation are likely to have evolved early. Here, we explore the role of lysine acetylation as a posttranslational modification to directly modulate metabolic function. We generated a lysine acetylome of the mossPhyscomitrium patensand identified 638 lysine acetylation sites, mostly found in mitochondrial and plastidial proteins. A comparison with available angiosperm data pinpointed lysine acetylation as a conserved regulatory strategy in land plants. Focusing on mitochondrial central metabolism, we functionally analyzed acetylation of malate dehydrogenase (mMDH), which acts as a hub of plant metabolic flexibility. InP. patensmMDH1, we detected a single acetylated lysine located next to one of the four acetylation sites detected inArabidopsis thalianamMDH1. We assessed the kinetic behavior of recombinantA. thalianaandP. patensmMDH1 with site-specifically incorporated acetyl-lysines. Acetylation ofA. thalianamMDH1 at K169, K170, and K334 decreases its oxaloacetate reduction activity, while acetylation ofP. patensmMDH1 at K172 increases this activity. We found modulation of the malate oxidation activity only inA. thalianamMDH1, where acetylation of K334 highly activated it. Comparative homology modelling of MDH proteins revealed that evolutionarily conserved lysines serve as hotspots of acetylation. Our combined analyses indicate lysine acetylation as a common strategy to fine-tune the activity of central metabolic enzymes with likely impact on plant acclimation capacity.Significance statementWe explore the role of lysine acetylation as a mechanism to directly modulate mitochondrial metabolism in land plants by generating the lysine acetylome of the mossPhyscomitrium patensand comparing with available angiosperm data. We found acetylation of evolutionarily conserved lysines as a strategy to fine-tune the activity of mitochondrial malate dehydrogenase in a species-dependent molecular context.
A multi-criteria decision-making model for selecting curtain wall systems in office buildings
Authors: Hamida Hamza , Alshibani Adel 
Published: October 2020

Purpose
The purpose of this paper is to develop a model that facilitates the evaluation and selection processes of curtain wall systems used in office buildings.

Design/methodology/approach
A comprehensive literature review and interviews with local experts were conducted to identify common types of curtain wall systems used in office buildings and their selection criteria. A questionnaire was designed and completed using multi-criteria decision-making techniques through face-to-face meetings with consultants in the Eastern Province of Saudi Arabia. The proposed model was implemented in prototype software as a proof of concept.

Findings
The results revealed that fire resistance scored the highest weighting of all the criteria. Furthermore, precast concrete cladding panels were found to be the best system for use in office buildings located in the Eastern Province of Saudi Arabia. The model validation reveals that the score for any curtain wall system varies depending on the nature of the project and that the prioritisation of criteria can vary from one practitioner to another.

Originality/value
The model captures the knowledge of professionals who are experts in the prioritisation of criteria for selecting curtain wall systems. The research design presented expands the boundaries of knowledge of the relevant literature, through demonstrating a conceptual framework incorporating different techniques into a computerised model. It has practical implications through presenting a systematic procedure for developing and adopting a computerised decision-making tool, which aligns experts’ professional practice and requirements, for use in selecting fragmented options.
The impact of team potency and leadership member exchange on expatriate creative work involvement
Authors: Almazrouei Hanan Saber , Zacca Robert , Alfayez Noura 
Published: October 2020

PurposeThe purpose of this study is to examine whether team potency moderates the effect of the leader member exchange (LMX) on the expatriate's creative work involvement such that the effect of leader member exchange on creative work involvement becomes less when team potency is high.Design/methodology/approachData were gathered via a printed survey instrument, using a purposive sampling approach and administered directly to 150 expatriate (non-Emirate nationals) employees located in the Jabal Ali Dubai Free Zone of the United Arab Emirates (UAE).FindingsOur findings indicate that the higher the level of team potency the less the effect of LMX on expatriate creative work involvement.Practical implicationsThe findings suggest that, team potency, which is an asset in certain situations, can be a liability suppressing the effect of LMX on the expatriate employees creative work involvement. Expatriate employees experiencing satisfaction and fulfillment through the leadership exchange feel sufficiently empowered in their abilities to engage in creative work behaviors.Originality/valueTesting a theoretical model within the intranational cultural diversity of an expatriate workforce may be a stronger source of diversity than other sources, providing for an original theoretical contribution to the extant literature. Moreover, the UAE, with its prominent network of expatriate employment integrated within the national economy presents a highly relevant contextual environment in which to study expatriate behavior.
COVID-19 economic shocks and fiscal policy options for Ghana
Authors: Dzigbede Komla D. , Pathak Rahul 
Published: October 2020

PurposeThis article examines the fiscal challenges the coronavirus pandemic poses in African countries, using Ghana as a case study and summarizes the country's immediate monetary and fiscal responses to the pandemic. The article also discusses the potential impacts of coronavirus-related shocks on the Ghana economy and policy options the national government may pursue to counteract the pandemic's adverse long-term effects.Design/methodology/approachThe article uses daily and monthly economic indicators to assess the immediate impact of the pandemic on Ghana's economy. The article also uses latest data from the Ghana Living Standards Survey (GLSS) to simulate potential shocks to the economy related to the coronavirus crisis and examines the outcomes from a potential government response that expands spending on an existing direct social assistance program.FindingsThe authors find that the coronavirus pandemic is associated with a significant increase in Ghana's poverty measures over time, and an expansion in government spending under an existing cash transfer program would partly offset the economic shocks related to the crisis and improve outcomes for poverty and inequality. The authors also argue that other well-targeted expenditure and revenue policies will support long-term economic resilience.Research limitations/implicationsThe research suggests that a temporary expansion of the existing program of direct cash payments to poor households may be an effective social protection policy, as are well-targeted revenue and spending policies that support economic recovery and long-term fiscal sustainability.Practical implicationsThe findings imply that while the pandemic might cause severe shocks in the economy, well-targeted spending and revenue policies that are anchored in sound macroeconomic management can promote economic resilience and long-term fiscal sustainability.Social implicationsPublic managers must ensure that national policy responses to the coronavirus pandemic consider socio-economic indicators, such as poverty and income inequality.Originality/valueThe authors present research that uses novel household-level data and an evidence-based microsimulation framework to articulate potential public policy strategies that can guide national responses to, and recovery from, the coronavirus pandemic.
Luxury brands’ use of CSR and femvertising: the case of jewelry advertising
Authors: Pankiw Stephanie A. , Phillips Barbara J. , Williams David E. 
Published: October 2020

Purpose
Luxury brands seek to differentiate themselves from competitors by engaging in corporate social responsibility (CSR) practices. Although many luxury brands participate in CSR activities, it is unclear if luxury brands communicate these CSR activities to consumers. Therefore, this study aims to explore two questions: are luxury jewelry brands communicating CSR (including women’s empowerment) in their advertising? And how should luxury jewelry brands communicate CSR messages in their advertising?

Design/methodology/approach
This paper uses a content analysis of luxury jewelry print advertisements and in-depth interviews with 20 female jewelry consumers analyzed using grounded theory to construct the luxury brand CSR advertising strategies theory.

Findings
Very few (3%) of print advertisements contain CSR messages, including femvertising and the theory presents four paths for brands to consider when promoting CSR practices, namely, ethical sourcing, cause-related marketing product, a signal of product care and quality and signal of an authentic relationship with the consumer.

Practical implications
The model provides four potential CSR advertising strategies and guidelines luxury jewelry brands can use to create successful advertising campaigns.

Originality/value
Luxury jewelry advertising has not been empirically examined and the study fills gaps in the understanding of luxury brands’ communication strategies. It adds to the knowledge and theorizing of the use and appropriateness of CSR appeals in a luxury brand context.
Detection of fatigue crack propagation through damage characteristic FWHM using FBG sensors
Authors: Zhang Meng , Zhang Weifang , Liang Xiaobei , Zhao Yan , Dai Wei 
Published: October 2020

Purpose
Crack damage detection for aluminum alloy materials using fiber Bragg Grating (FBG) sensor is a kind of structure health monitoring. In this paper, the damage index of full width at half maximum (FWHM) was extracted from the distorted reflection spectra caused by the crack-tip inhomogeneous strain field, so as to explain the crack propagation behaviors.

Design/methodology/approach
The FWHM variations were also investigated through combining the theoretical calculations with simulation and experimental analyses. The transfer matrix algorithm was developed to explore the mechanism by which FWHM changed with the linear and quadratic strain. Moreover, the crack-tip inhomogeneous strain field on the specimen surface was computed according to the digital image correlation measurement during the experiments.

Findings
The experimental results demonstrated that the saltation points in FWHM curve accorded with the moments of crack propagation to FBG sensors.

Originality/value
The interpretation of reflected spectrum deformation mechanism with crack propagation was analyzed based on both simulations and experiments, and then the performance of potential damage features – FWHM were proposed and evaluated. According to the correlation between the damage characteristic and the crack-tip location, the crack-tip of the specimen could be measured rapidly and accurately with this technique.
Effect of Sb additions on the creep behaviour of low temperature lead-free Sn–8Zn–3Bi solder alloy
Authors: Ren Guang , Collins Maurice 
Published: October 2020

Purpose
This paper aims to investigate the creep behaviour of the recently developed Sn–8Zn–3Bi–xSb (x = 0, 0.5, 1.0 and 1.5) low temperature lead-free solder alloys.

Design/methodology/approach
An in-house compressive test rig was developed to perform creep tests under stresses of 20–40 MPa and temperature range 25°C–75 °C. Dorn power law and Garofalo hyperbolic sine law were used to model the secondary creep rate.

Findings
High coefficient of determination R2 of 0.99 is achieved for both the models. It was found that the activation energy of Sn–8Zn–3Bi solder alloy can be significantly increased with addition of Sb, by 60% to 90 kJ/mol approximately, whereas the secondary creep exponent falls in the range 3–7. Improved creep resistance is attributed to solid solution strengthening introduced by micro-alloying. Creep mechanisms that govern the deformation of these newly developed lead-free solder alloys have also been proposed.

Originality/value
The findings are expected to fill the gap of knowledge on creep behaviour of these newly developed solder alloys, which are possible alternatives as lead-free interconnecting material in low temperature electronic assembly.
Collective orientation and its implications for coordination and team performance in interdependent work contexts
Authors: Hagemann Vera , Ontrup Greta , Kluge Annette 
Published: October 2020

Purpose
This paper aims to explore the influence of collective orientation (CO) on coordination and team performance for interdependently working teams while controlling for person-related and team variables.

Design/methodology/approach
A total of 58 two-person-teams participated in a simulation-based firefighting task. The laboratory study took 2 h for each team. The effects of CO in tasks of increasing complexity were investigated under the consideration of control variables, and the relations between CO, coordination and team performance were assessed using a multivariate latent growth curve modeling approach and by estimating indirect effects in simple mediation models.

Findings
Team members high on CO performed significantly better than low-scoring members. The effect of CO on team performance was independent from an increasing task complexity, whereas the effect of CO on coordination was not. The effect of CO on team performance was mediated by coordination within the team, and the positive relation between CO and performance persists when including group efficacy into the model.

Research limitations/implications
As CO is a modifiable person-related variable and important for effective team processes, additional research on factors influencing this attitude during work is assumed to be valuable.

Practical implications
CO is especially important for highly interdependently working teams in high-risk-organizations such as the fire service or nuclear power plants, where errors lead to severe consequences for human beings or the environment.

Originality/value
No other studies showed the importance of CO for coordination and team performance while considering teamwork-relevant variables and the interdependence of work.
3D numerical back-analysis of an instrumented underpass road
Authors: Houhou Mohamed Nabil , Belounar Abderahim , Amari Tamir , Brouthen Abdelaziz 
Published: October 2020

Purpose
This paper aims to focus on three-dimensional (3D) numerical simulation of a monitored urban underground road consisting of diaphragm walls supported by one row of temporary steel struts and a cover slab in the central area. In addition to the lateral wall displacements, the analysis focuses on the load development in the struts and the evolution of the total stresses at the soil–wall interface, and highlights the 3D effect on the behavior of the structure.

Design/methodology/approach
Computation by back-analysis has become an important contribution to the understanding of observed phenomena. In this context, this paper investigates a full 3D numerical back-analysis of diaphragm wall deformation using the finite difference code FLAC3D.

Findings
The instrumentation allows a deep understanding of the ground response and the soil-structure interaction phenomena. It also provides an opportunity to validate numerical models. Using a soil model with simple failure criteria, the wall displacements are strongly influenced by the soil deformation modulus. The strut stiffness considerably influences the wall behavior. The geometrical effects have a significant impact on the induced wall displacements.

Originality/value
In the present study, the main soil geotechnical characteristics were deduced from laboratory and in situ tests. However, Young’s modulus of the soil has been adjusted to take account of the unloading effect. In the same context, the non-linearity of the elastic characteristics of the steel struts has been taken into account by modeling the struts using their experimental stiffness instead of their theoretical rigidity.
Multi-response optimization of EDM parameters using grey relational analysis (GRA) for Ti-5Al-2.5Sn titanium alloy
Authors: Bhaumik Munmun , Maity Kalipada 
Published: October 2020

Purpose
In this research, electro discharge machining (EDM) of Ti-5Al-2.5Sn titanium alloy is performed taking gap voltage, pulse on time, peak current and duty cycle as process parameters. The purpose of this paper is to find out the optimal process parameters setting for getting higher machining efficiency.

Design/methodology/approach
For experimental design, a face-centered central composite design (FCCCD)-based response surface methodology (RSM) is used. Multi-objective optimization like grey relational analysis (GRA) is adopted to achieve the higher machining efficiency by means of lower radial overcut (ROC), surface roughness (Ra), tool wear rate (TWR) and higher material removal rate (MRR). For the statistical study, analysis of variance (ANOVA) has been carried out.

Findings
The result shows that gap voltage, peak current and pulse on time are the most efficient parameters for the responses. An optimal parameter setting has been obtained for achieving higher machining efficiency. For validation of the study, confirmation experiment has been performed at optimal parameters setting.

Originality/value
Optimum parameter level for higher machining performance of Ti-5Al-2.5Sn Titanium alloy has been achieved machined by copper electrode during EDM operation.
Lytic and sublytic effects of gossypol on red blood cells and thymocytes
Authors: Chorieva Nargiza M. , Fayziev Diyor D. , Tsiferova Nargiza A. , Toshtemirova Gulnoza A. , Khamidova Ozoda J. , Merzlyak Petr G. , Kurbannazarova Ranokhon Sh. , Ziyaev Khayrulla L. , Gafurov Makhmud B. , Sabirov Ravshan Z. 
Published: October 2020

AbstractGossypol is a natural polyphenol presently considered as a promising biological phytochemical with a range of activities including anticancer. We examined volume regulation‐dependent effects of gossypol using erythrocytes and thymic lymphocytes. Gossypol effectively lysed human red blood cells (RBC) with a half‐maximal concentration of 67.4 ± 1.6 μmol/L and in a non‐colloid osmotic manner. Sublytic gossypol doses of 1–10 μmol/L significantly protected RBC from osmotic hemolysis, but potentiated their sensitivity to the colloid‐osmotic lysis induced by a pore‐former nystatin. When added to the thymocytes suspension, gossypol caused a strong depression of the ability of cells to restore their volume under hypoosmotic stress with a half‐maximal activity at 2.1 ± 0.3 μmol/L. Gossypol suppressed regulatory volume decrease under experimental conditions, when cationic permeability was controlled by gramicidin D, and volume recovery depended mainly on anionic conductance, suggesting that the polyphenol inhibits the swelling‐induced anion permeability. In direct patch‐clamp experiments, gossypol inhibited the volume‐sensitive outwardly rectifying (VSOR) chloride channel in thymocytes and in human HCT116 and HeLa cells, possibly by a mechanism when gossypol molecule with a radius close to the size of channel pore plugs into the narrowest portion of the native VSOR chloride channel. Micromolar gossypol suppressed proliferation of thymocytes, HCT116 and HeLa cells. VSOR blockage may represent new mechanism of anticancer activity of gossypol in addition to its action as a BH3‐mimetic.
From Implicit to Explicit: The Impact of Disclosure Requirements on Hidden Transaction Costs
Authors: CUNY CHRISTINE , EVEN‐TOV OMRI , WATTS EDWARD M. 
Published: October 2020

ABSTRACTThis paper provides evidence that disclosing corporate bond investors' transaction costs (markups) affects the size of the markups. Until recently, markups were embedded in the reported transaction price and not explicitly disclosed. Without explicit disclosure, investors can estimate their markups using executed transaction prices. However, estimating markups imposes information processing costs on investors, potentially creating information asymmetry between unsophisticated investors and bond‐market professionals. We explore changes in markups after bond‐market professionals were required to explicitly disclose the markup on certain retail trade confirmations. We find that markups decline for trades that are subject to the disclosure requirement relative to those that are not. The findings are pronounced when constraints on investors' information processing capacity limit their ability to be informed about their markups without explicit disclosure.
Effects of ethyl acetate fractional extract fromPortulaca oleraceaL. (PO‐EA) on lifespan and healthspan inCaenorhabditis elegans
Authors: Zhang Wenwen , Zheng Bisheng , Deng Na , Wang Hong , Li Tong , Liu Rui Hai 
Published: October 2020

AbstractPortulaca oleraceaL. (PO), with abundant natural bioactive phytochemicals, exhibits potential bioactivities and pharmacological activities. However, the mechanisms of action of PO on anti‐aging effect remain unclear. In this study, the ethyl acetate fractional extract from PO (PO‐EA) was obtained by fractionation of solvent extractions, and its effect on lifespan was assessed using theCaenorhabditis elegans(C. elegans). Results showed that PO‐EA could significantly increase the lifespan ofC. elegansby 5.31, 12.67, and 16.47% at the doses of 250, 500, and 1,000 µg/mL, respectively. Moreover, PO‐EA significantly promoted the mobility ofC. eleganswithout obvious side effects such as changing body length or decreasing fecundity of the nematodes. Further study demonstrated that PO‐EA could enhance the stress resistance inC. elegansvia improving the activities of superoxide dismutase and catalase, and diminishing the contents of reactive oxygen species and malondialdehyde. The gene expression ofdaf‐12,daf‐16,sod‐3,skn‐1,cat‐1,mev‐1,akt‐1, andsek‐1were upregulated inC. elegansafter administrated by PO‐EA. This study indicated that PO‐EA plays a vital role in extending lifespan and healthspan inC. elegans, and the underlying mechanism of action might be attributed to Insulin/IGF‐1‐like signaling pathways. Therefore, PO‐EA could be served as a potential candidate for anti‐aging functional food.Practical ApplicationPortulaca oleraceaL. (PO) is an edible vegetable that could be used as functional food to exert health benefits for humans such as neuroprotective, antioxidant, anticancer, and anti‐aging effects. Therefore, our findings would provide a strategy to promote the comprehensive utilization of ethyl acetate extract from PO with additional health benefits.
Defining how microorganisms benefit human health
Authors: Marco Maria L. 
Published: October 2020

SummaryAn appreciation for how microorganisms can benefit human health has grown over the past century. The future of this research will be to identify the specific microbial enzymatic pathways and molecules necessary for health promotion. Some of these ‘beneficial factors’ are already known for probiotics and species in the human microbiome, however, precise descriptions of the mechanistic details for their effects remain to be discovered. The need for this research is elevated by the potential use of microorganisms for preventing and treating the non‐communicable diseases which are now the leading causes of death worldwide.