bluuebunny/crossref_metadata_2025_split huggingface dataset:
Building a hospital‐based addiction medicine consultation service in Vancouver, Canada: the path taken and lessons learned
Authors: Braithwaite Vivian , Ti Lianping , Fairbairn Nadia , Ahamad Keith , McLean Mark , Harrison Scott , Wood Evan , Nolan Seonaid 
Published: December 2020

AbstractBackground and aimsTo improve evidence‐based addiction care in acute care settings, many hospitals across North America are developing an inpatient addiction medicine consultation service (AMCS). St Paul's Hospital in Vancouver, Canada houses a large interdisciplinary AMCS. This study aimed to: (1) describe the current model of clinical care and its evolution over time; (2) evaluate requests for an AMCS consultation over time; (3) highlight the established clinical training opportunities and educational curriculum and (4) provide some lessons learned.Design, setting and participantsA retrospective observational analysis in an urban, academic hospital in Vancouver, Canada with a large interdisciplinary AMCS, studied from 2013 to 2018, among individuals who presented to hospital and had a substance use disorder.MeasurementsData were collected using the hospital's electronic medical records. The primary outcome was number of AMCS consultations over time.FindingsIn 2014 the hospital's AMCS was restructured into an academic, interdisciplinary consultation service. A 228% increase in the number of consultations was observed between 2013 (1 year prior to restructuring) and 2018 (1373 versus 4507, respectively; P = 0.027). More than half of AMCS consultations originated from the emergency department, with this number increasing over time (55% in 2013 versus 74% in 2018). Referred patients were predominantly male (> 60% in all 5 years) between the ages of 45 and 65 years. Reasons for consultation remained consistent and included: opioids (33%), stimulants (30%), alcohol (23%) and cannabis use (8%).ConclusionsAfter St Paul's Hospital in Vancouver, Canada was restructured in 2014 to a large, interdisciplinary addiction medicine consultation service (AMCS), the AMCS saw a 228% increase in the number of consultation requests with more than half of requests originating from the emergency department. Approximately two‐thirds of consultation requests were for opioid or stimulant use.
Australian Bogong moths Agrotis infusa (Lepidoptera: Noctuidae), 1951–2020: decline and crash
Authors: Green Ken , Caley Peter , Baker Monika , Dreyer David , Wallace Jesse , Warrant Eric 
Published: December 2020

AbstractThe Bogong moth Agrotis infusa is well known for its remarkable long‐distance migration – a return journey from the plains of southeast Australia to the Australian Alps – as well as for its cultural significance for Indigenous Australians. Each spring, as many as four billion moths are estimated to arrive in the Australian Alps to aestivate in cool mountain caves and in boulder fields, bringing with them a massive annual influx of energy and nutrients critical for the health of the alpine ecosystem. However, a massive decline in moths present at their aestivation sites has occurred over the past 3 years, with only a few individuals present where hundreds of thousands could earlier be found. In order to understand the possible sources of decline, we analysed historical records of Bogong moth numbers at aestivation sites in the Australian Alps, including observations on Mt. Gingera (NSW) in the early 1950s, observations from 1980 onwards in the Snowy Mountains (NSW) and an almost‐unbroken series of observations each summer over the past 53 years in three caves at different elevations on Mt. Buffalo (Victoria). This analysis shows that moth numbers were probably steady from 1951 until about 1980, fluctuated and slowly fell from then until 2016 and dramatically crashed in 2017. In the Murray–Darling Basin, the main winter breeding ground of Bogong moths, changes in farming practices, such as increasing land clearing for crops (which has removed around a quarter of a billion moths annually from the mountains compared to pre‐European levels), has probably driven some of the decline in Bogong moth numbers observed from 1980 to 2016. The impact of insecticide remains unclear and is in urgent need of further study. Even though we found little evidence that increasing global temperatures per se are responsible for the Bogong moth decline, the Australian climate has nonetheless become drier and warmer over past decades, possibly hampering the survival of immature stages in the breeding areas and confining adult aestivation to gradually higher elevations. The crash in moth numbers from 2017 is most likely due to the recent severe drought in the moth's breeding grounds.
An anatomical study of the dorsal and ventral nasal conchal bullae and middle nasal conchae in normal Shetland ponies: Computed tomographic anatomical and morphometric findings
Authors: Gerlach Kerstin , Vervuert Ingrid , Gittel Claudia , Köhler Lisa , Schmidt Nane , Winter Karsten , Berner Dagmar , Troillet Antonia , Schulz‐Kornas Ellen 
Published: December 2020

AbstractEquine paranasal sinuses are susceptible to inflammation. Insufficient drainage through the nasal passages and meatus may lead to the accumulation of inspissated purulent discharge. Particularly in ponies, these anatomical structures are suspected to be relatively small. To date, there are no reports considering the morphology of nasal conchal bullae in small horse breeds such as Shetland ponies. The aim of the present study was to evaluate the size of the conchal bullae and the medial nasal conchae of Shetland ponies and their relation to the skull dimension using computed tomography. Reconstructed images of healthy adult heads of Shetland ponies were used. Linear skull measurements as well as two cranial indices of the head dimensions were taken. Length, width and height of the dorsal and ventral conchal bullae and the medial nasal conchae were measured in relation to the skull and compared with the data of skulls of large breed horses. The anatomical proportions of pony heads were characterized by a smaller cranial index and a greater nasal index than those of large breed horses. Shetland ponies showed a longer cranial length compared with the nasal length. Heads are consistently smaller, and the relationship of the bullae to the head length was also smaller than those measured in large breed horses. A negative correlation between the head and bullae size was found. In conclusion, this study suggests that Shetland ponies have distinguishing proportions of the head. These findings are relevant for clinical examination and surgical treatment of equine sinus disease in those breeds.
‘I’d rather die in the middle of a street’: Perceptions and expectations of aged care among Forgotten Australians
Authors: Browne‐Yung Kathryn , O’Neil Diana , Walker Ruth , Smyth Alison , Putsey Peter , Corlis Megan , Laver Kate E. , Fernandez Elizabeth , Cations Monica 
Published: December 2020

AbstractObjectivesTo explore perceptions and expectations regarding aged care among older Forgotten Australians, informing better ways of delivering safe and inclusive care for this group.MethodsIn‐depth interviews were undertaken with sixteen Forgotten Australians to understand their perspectives, hopes and perceived barriers to receiving appropriate aged care. Qualitative data were analysed using Ritchie and Spencer's framework approach.ResultsParticipants were highly averse to receiving aged care in residential settings, particularly where delivered by religious organisations. Limited perceived opportunities to develop trust and maintain control and independence while managing re‐traumatising situations shaped Forgotten Australians negative perceptions of the aged care system. Participants also spoke of how their lifelong marginalisation could limit their access to choice and quality in aged care.ConclusionThe aged care industry could provide safe and inclusive care by adopting a person‐centred and trauma‐informed model that recognises and addresses the specific needs and challenges of Forgotten Australians.
Neutrophilic dermatosis: a new skin manifestation and novel pathogenic variant in a rare autoinflammatory disease
Authors: Bardou Maine Luellah Demaret , Rivitti‐Machado Maria Cecilia , Michalany Nilceo Schwery , de Jesus Adriana Almeida , Goldbach‐Mansky Raphaela , Barros João Coriolano Rego , Terreri Maria Teresa de Sande e Lemos Ramos Ascensão , Grumach Anete Sevciovic 
Published: December 2020

AbstractSideroblastic anaemia, B‐cell immunodeficiency, periodic fever and developmental delay (SIFD) is caused by mutations of TRNT1, an enzyme essential for mitochondrial protein synthesis, and has been reported in 23 cases. A 6‐month‐old girl was evaluated with recurrent fever, failure to thrive, skin lesions and anaemia. She received blood transfusions and empirical antibiotics. Skin lesions, previously interpreted as insect bites, consisted of numerous firm asymptomatic erythematous papules and nodules, distributed over trunk and limbs. Skin histopathology revealed an intense dermal neutrophilic infiltrate extending to the subcutaneous, with numerous atypical myeloid cells, requiring the diagnosis of leukaemia cutis, to be ruled out. Over the follow‐up, she developed herpetic stomatitis, tonsillitis, lobar pneumonia and Metapneumovirus tracheitis, and also deeper skin lesions, resembling panniculitis. Hypogammaglobulinaemia was diagnosed. An autoinflammatory disease was confirmed by whole exome sequencing: heterozygous mutations for TRNT1 NM_182916 c.495_498del, p.F167Tfs * 9 and TRNT1 NM_182916 c.1246A>G, p.K416E. The patient has been treated with subcutaneous immunoglobulin and etanercept. She presented with developmental delay and short stature for age. The fever, anaemia, skin neutrophilic infiltration and the inflammatory parameters improved. We describe a novel mutation in SIFD and the first to present skin manifestations, namely neutrophilic dermal and hypodermal infiltration.
Does aspirin prescribed to women deemed high risk for preterm pre‐eclampsia at 11–13+6 weeks gestation affect the prevalence of small for gestational age neonates?
Authors: Park Felicity , O’Brien Cecelia , Phung Jason , Emeto Theophilus , Hyett Jon 
Published: December 2020

BackgroundAspirin has been shown to reduce prevalence of both early‐onset pre‐eclampsia (ePET) and fetal growth restriction (FGR).AimsTo determine whether aspirin prescribed for risk of ePET reduces the prevalence of small for gestational age (SGA) neonates.Material and MethodsTwo prospective cohorts were consecutively recruited in a large university hospital in Sydney. The Observational cohort (April 2010 to March 2012) validated an algorithm for ePET screening, where risk for ePET was modelled on history, mean arterial pressure, uterine artery pulsatility index and pregnancy‐associated plasma protein A. The Interventional cohort (April 2012 to December 2017) were screened and allocated women at high risk of developing ePET to aspirin 150 mg. The prevalence of preterm and term SGA was compared using regression analysis.ResultThere were 3013 and 8424 women screened in the Observational and Interventional cohorts respectively. Women who screened high risk for ePET were three to four times more likely to give birth to a neonate classified as SGA in the Observational (6.8% vs 1.9%) and Interventional cohorts (6.0% vs 1.8%). In women who screened high risk, there were no statistically significant differences in the prevalence of SGA neonates (6.6% vs 6.0%; adjusted odds ratio 0.84 (0.50–1.42)) in women who received aspirin compared to women who did not.ConclusionsWomen who screen high risk for ePET have an increased chance of delivering an SGA infant. A reduction in the prevalence of SGA neonates when aspirin was prescribed to women who screened high risk for ePET did not reach clinical significance in our cohort.
Perceptions of UK clinicians towards postoperative critical care
Authors: Hashim S. , Wong D. J. N. , Farmer L. , Harris S. K. , Moonesinghe S. R. 
Published: December 2020

SummaryPostoperative critical care is a finite resource that is recommended for high‐risk patients. Despite national recommendations specifying that such patients should receive postoperative critical care, there is evidence that these recommendations are not universally followed. We performed a national survey aiming to better understand how patients are risk‐stratified in practice; elucidate clinicians’ opinions about how patients should be selected for critical care; and determine factors which affect the actual provision of postoperative critical care. As part of the second Sprint National Anaesthesia Project, epidemiology of critical care after surgery study, we distributed a paper survey to anaesthetists, surgeons and intensivists providing peri‐operative care during a single week in March 2017. We collected data on respondent characteristics, and their opinions of postoperative critical care provision, potential benefits and real‐world challenges. We undertook both quantitative and qualitative analyses to interpret the responses. We received 10,383 survey responses from 237 hospitals across the UK. Consultants used a lower threshold for critical care admission than other career grades, indicating potentially more risk‐averse behaviour. The majority of respondents reported that critical care provision was inadequate, and cited the value of critical care as being predominantly due to higher nurse: patient ratios. Use of objective risk assessment tools was poor, and patients were commonly selected for critical care based on procedure‐specific pathways rather than individualised risk assessment. Challenges were highlighted in the delivery of peri‐operative critical care services, such as an overall lack of capacity, competition for beds with non‐surgical cases and poor flow through the hospital leading to bed ‘blockages’. Critical care is perceived to provide benefit to high‐risk surgical patients, but there is variation in practice about the definition and determination of risk, how patients are referred and how to deal with the lack of critical care resources. Future work should focus on evaluating ‘enhanced care’ units for postoperative patients, how to better implement individualised risk assessment in practice, and how to improve patient flow through hospitals.
Perinatal outcomes of twin pregnancies complicated by late twin‐twin transfusion syndrome: A systematic review and meta‐analysis
Authors: Sileo Filomena Giulia , D’antonio Francesco , Benlioglu Can , Bhide Amar , Khalil Asma 
Published: December 2020

AbstractIntroductionUntreated twin‐to‐twin transfusion syndrome (TTTS) is associated with a high risk of perinatal mortality and morbidity. Laser surgery is recommended before 26 weeks of gestation. However, the optimal management in case of late TTTS (occurring after 26 weeks of gestation) is yet to be established.Material and methodsWe conducted a systematic review and meta‐analysis to evaluate the outcomes of monochorionic‐diamniotic twin pregnancies complicated by late TTTS according to different management options (expectant, laser therapy, amnioreduction, or delivery). The primary outcome was mortality, including single and double intrauterine, neonatal, and perinatal death. Secondary outcomes were composite morbidity, neuromorbidity, respiratory distress syndrome, admission to neonatal intensive care unit, intact survival (ie, free from neurological complications), and preterm birth before <32 weeks of gestation. Outcomes were reviewed according to the management and reported for the overall population of twins and disease status (ie, donor and recipient separately). Random‐effect meta‐analyses of proportions were used to analyze the data.ResultsNine studies including 796 twin pregnancies affected by TTTS were included. No randomized controlled trials were available for inclusion. TTTS occurred at ≥26 weeks of gestation in 8.7% (95% CI 6.9%‐10.9%; 67/769) of cases reporting TTTS at all gestations. Intrauterine death occurred in 17.7% (95% CI 4.9%‐36.2%) of pregnancies managed expectantly, 5.3% (95% CI 0.9%‐12.9%) of pregnancies treated with laser, and 0% (95% CI 0%‐9%) after amnioreduction. Neonatal death occurred in 42.5% (95% CI 17.5%‐69.7%) of pregnancies managed expectantly, in 2.8% (95% CI 0.3%‐7.7%) of cases treated with laser, and in 20.2% (95% CI 6%‐40%) after amnioreduction. Only one study (10 cases) reported data on immediate delivery after diagnosis with no perinatal deaths. Perinatal death incidence was 55.7% (95% CI 31.4%‐78.6%) in twin pregnancies managed expectantly, 5.6% (95% CI 0.5%‐15.3%) in those treated with laser, and 20.2% (95% CI 6%‐40%) in those after amnioreduction. Intact survival was reported in 44.4%, 96.4%, and 78% of fetuses managed expectantly, with laser or amnioreduction, respectively.ConclusionsEvidence regarding perinatal mortality and morbidity in twin pregnancies complicated by late TTTS according to the different managements was of very low quality. Therefore further high‐quality research in this field is needed to elucidate the optimal management of these pregnancies.
Uterine contractions in rodent models and humans
Authors: Malik Manasi , Roh Michelle , England Sarah K. 
Published: December 2020

AbstractAberrant uterine contractions can lead to preterm birth and other labour complications and are a significant cause of maternal morbidity and mortality. To investigate the mechanisms underlying dysfunctional uterine contractions, researchers have used experimentally tractable small animal models. However, biological differences between humans and rodents change how researchers select their animal model and interpret their results. Here, we provide a general review of studies of uterine excitation and contractions in mice, rats, guinea pigs, and humans, in an effort to introduce new researchers to the field and help in the design and interpretation of experiments in rodent models.
Implicit black‐weapon associations weakened over time in increasingly multiethnic metropolitan areas
Authors: Somo Angela , Sadler Melody , Devos Thierry 
Published: December 2020

AbstractA repeated cross‐sectional design was used to examine whether temporal changes in implicit Black‐weapon associations were dependent on the changing ethnic diversity of metropolitan areas over the course of a decade (2009–2018). Data on implicit Black‐weapon associations were obtained from Project Implicit. Three indicators of ethnic diversity were calculated using American Community Survey data. Minority representation referred to the proportion of African American residents. Variety was operationalized as the degree to which six ethnic groups each accounted for an equal proportion of the population. Integration assessed the degree to which ethnic groups were evenly distributed across census tracts making up the metropolitan area. Multilevel model analyses (N = 345,647 participants, nested within 185 metropolitan areas) revealed that implicit Black‐weapon associations weakened over time, and to a larger degree in metropolitan areas characterized by steeper increases in variety. This longitudinal relationship is consistent with the notion that, as metropolitan areas become more multiethnic, implicit associations between crime, danger, or violence and Black Americans decline.
Development of the Timed Re‐Insemination (TRI‐synch) program re‐inseminating 24 days after the initial service in dairy cows
Authors: Aizu Marina , Ido‐Matsumoto Haruka , Wada Natsumi , Kumazaki Hiromasa , Kubo Tomoaki , Kanazawa Tomomi , Izaike Yoshiaki , Takahashi Toru 
Published: December 2020

AbstractFor the timed re‐insemination at the minimal interbreeding interval, cows were treated with a progesterone (P4)‐releasing intravaginal device from Days 13–15 to 21 post‐insemination (Day 0 = estrus), followed by plasma P4 assay on Day 23 and then subjected to the Experiments 1 and 2. In Experiment 1, of 18 cows, 6 cows were determined as luteolysis with low (<1 ng/ml) plasma P4 concentrations on Day 23 and ovulated on Days 24 (3 cows), 25 (1 cow), and 26 (1 cow) except a cow affected by ovarian quiescence. In Experiment 2, all cows were treated with GnRH on Day 23. Cows with low (<1 ng/ml) plasma P4 concentrations on Day 23 were diagnosed as non‐pregnant and subjected to the re‐insemination in the morning of Day 24 irrespective of estrous signs. Of 36 cows, 15 cows were diagnosed as being non‐pregnant on Day 23. Fourteen cows of the non‐pregnant animals were re‐inseminated in the morning of Day 24 irrespective of estrous signs and the pregnancy rate of re‐insemination was 36%. The conception rates of initial and re‐inseminations were 50% (18/36) and 36% (5/14), respectively. The overall pregnancy rate by adding the rates of initial and re‐inseminations was 64% (23/36).
Embryo production by intracytoplasmic injection of sperm retrieved from neonatal testicular tissue of Agu pigs after cryopreservation and grafting into nude mice
Authors: Kaneko Hiroyuki , Kikuchi Kazuhiro , Men Nguyen Thi , Dang‐Nguyen Thanh Quang , Oyadomari Motoharu , Touma Shihei , Suzuki Naoto , Katagiri Yoshito 
Published: December 2020

AbstractThe Agu is the only indigenous pig breed in Japan but its population is very small. In order to estimate the efficacy of testicular xenografting for the conservation of Agu pigs, we investigated whether neonatal testicular fragments would acquire the capacity to produce sperm after they had been cryopreserved and grafted into nude mice. Although on day 180 (day 0 = xenografting), grafts showed a low proportion of seminiferous tubule cross‐sections containing sperm (0.1 ± 0.1%, mean ± SEM for four mice), the proportion reached 36.9 ± 16.7% (n = 4 mice) by day 240. When single sperm obtained on day 240 was injected into individual porcine oocytes, 28.2% of the oocytes were found to contain one male and one female pronuclei with the second polar body. Moreover, the blastocyst formation rate after injection of the xenogeneic sperm was 28.4%, whereas that in the absence of sperm injection (attributable to parthenogenesis) was 13.3%. These findings suggest that more than half of the blastocysts resulted from fertilization. Thus, testicular xenografting could assist the conservation of Agu pigs by salvaging germ cells present in neonatal testes even after cryopreservation.
Genetic relationships of calving difficulty with birth measurements and carcass traits in Japanese Black cattle
Authors: Hosono Masahiko , Oyama Hidemi , Inoue Keiichi 
Published: December 2020

AbstractThe objectives of this study were to compare the genetic parameters for calving difficulty (CD), which were treated as both a calf trait (CD_calf) and as a dam trait (CD_dam), and to clarify genetic relationships of these CDs with body size traits of calves at birth and carcass traits. In total, the CD records and calf body measurements of 2,258 Japanese Black cattle heifers were used in this study, in addition to the carcass records of 4,300 feedlot steers and heifers. Direct heritability of CD_calf (0.44) was higher than maternal heritability of CD_calf (0.30), as well as CD_dam heritability (0.25). Direct genetic correlations between CD_calf and calf body size were moderate to strongly positive (0.64 to 0.81). The correlations between EBVs of CDs and carcass weight were also positive (0.30 to 0.64). These positive relationships showed that genetically improving CD (reducing dystocia) could produce smaller calves and carcasses. In contrast, the correlations between CDs and beef marbling score were weak, suggesting that improving CD would not influence meat quality traits. Fitting an animal model to CD_calf could be more preferred to fitting the model to CD_dam, because the former could separate the genetic effects of dams and calves.