bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remdesivir Efficacy in Coronavirus Disease 2019 (COVID-19): A Systematic Review
Authors: Roshanshad Amirhossein , Kamalipour Alireza , Ashraf Mohammad Ali , Roshanshad Romina , Akbari Mohammad Reza 
Published: June 2020

AbstractBackgroundResearchers are working hard to find an effective treatment for the new coronavirus 2019. We performed a comprehensive systematic review to investigate the latest clinical evidence on the treatment efficacy and safety of Remdesivir in hospitalized patients with COVID-19.MethodsWe performed a systematic search of the Pubmed, Embase, Web of Science, Google scholar, and MedRxiv for relevant observational and interventional studies. Measured outcomes were mortality rates, improvement rates, time to clinical improvement, all adverse event rates and severe adverse event rates.Results3 RCTs and 2 cohorts were included in our study. In 2 cohort studies, patients received Remdesivir for 10 days. 2 RCTs evaluated 10-day treatment of Remdesivir efficacy versus placebo group and the other RCT compared its 5-day regimen versus 10-day regimen. Visual inspection of the forest plots revealed that Remdesivir efficacy was not much different in reducing 28-day mortality versus 14-day mortality rates. Besides, 10-day treatment regimen overpowers 5-day treatment and placebo in decreasing time to clinical improvement. All adverse event rates did not have significant difference; however, severe adverse event rate was lower in 5-day Remdesivir group compared to 10-day and placebo groups.Conclusion5-day course of Remdesivir therapy in COVID-19 patients is probably efficacious and safe and patients without invasive mechanical ventilation benefit the most. Treatment can be extended to 10 days if satisfactory improvement is not seen by day 5. Most benefits from Remdesivir therapy take place in the first 14 days of the start of the treatment.
Experimental investigation using micro-PIV of the effect of microRNA-1 deficiency on motility inCaenorhabditis elegans
Authors: Ravikumar S. , Fedrizzi M. , Prabhakar R. , Pocock R. , O’Bryan M. K. , Soria J. 
Published: June 2020

AbstractCaenorhabditis elegansis a microscopic nematode used extensively as a model organism in studies of neuromuscular function and neurodegenerative disorders. A mutation inmir-1affects signalling at the neuromuscular junction. We investigate the effect of this mutation on the propulsive power exerted by nematodes as they grow in size with age. We compare the motility of wild-type andmir-1(gk276)mutant nematodes in a Newtonian fluid using a two-component, two dimensional (2C-2D) Digital Microscopic Particle Image Velocimetry (µ-PIV) technique. Beating amplitudes of the head and tail, the wavelength of undulatory waves and the swimming speed scale linearly with size in both the wild-type and mutant strains. The beating frequency is independent of size or position along the body. Differences in the magnitudes of these kinematic parameters between the two strains, however, grow systematically with age. The swimming speed scales linearly with the wave speed of the neuromuscular undulation in both nematode strains with a conserved ratio. The magnitude of mean power and mean local fluid circulation in the mutant is significantly lower compared to those of the wild-type animals of the same age. This indicates that a mutation inmir-1adversely affects motility inC. elegans.
Airway-associated macrophages in homeostasis and repair
Authors: Engler Anna E. , Ysasi Alexandra B. , Pihl Riley M.F. , Villacorta-Martin Carlos , Heston Hailey M. , Richardson Hanne M.K. , Moniz Noah R. , Belkina Anna C. , Mazzilli Sarah A. , Rock Jason R. 
Published: June 2020

SummaryThere is an increasing appreciation for the heterogeneity of myeloid lineages in the respiratory system, but whether distinct populations associate with the conducting airways remains unknown. We use single cell RNA sequencing, flow cytometry and immunofluorescence to characterize myeloid cells of the mouse trachea during homeostasis and epithelial injury/repair. We identify submucosal macrophages that are similar to lung interstitial macrophages and intraepithelial macrophages, and find that repair of the tracheal epithelium is impaired inCcr2-deficient mice. Following injury there are early increases in neutrophils and submucosal macrophages, including M2-like macrophages. Unexpectedly, intraepithelial macrophages are initially lost but later replaced from CCR2+monocytes. Mast cells and group 2 innate lymphoid cells are sources of IL13 that polarizes macrophages and directly influences basal cell behaviors. Their proximity to the airway epithelium establishes these myeloid populations as potential therapeutic targets for airway disease.
Wnt- and Glutamate-receptors orchestrate stem cell dynamics and asymmetric cell division
Authors: Junyent Sergi , Reeves Joshua , Szczerkowski James L. A. , Garcin Clare L. , Trieu Tung-Jui , Wilson Matthew , Lundie-Brown Jethro , Habib Shukry J. 
Published: June 2020

ABSTRACTThe Wnt-pathway is part of a signalling network that regulates many aspects of cell biology. Recently we discovered crosstalk between AMPA/Kainate-type ionotropic glutamate receptors (iGluRs) and the Wnt-pathway during the initial Wnt3a-interaction at the cytonemes of embryonic stem cells (ESCs). Here, we demonstrate that this crosstalk persists throughout the Wnt3a-response in ESCs. Both AMPA- and Kainate-receptors regulate early Wnt3a-recruitment, dynamics on the cell membrane, and orientation of the spindle towards a Wnt3a-source at mitosis. AMPA-receptors specifically are required for segregating cell fate components during Wnt3a-mediated asymmetric cell division (ACD). Using Wnt-pathway component knockout lines, we determine that Wnt co-receptor Lrp6 has particular functionality over Lrp5 in cytoneme formation, and in facilitating ACD. Both Lrp5 and 6, alongside pathway effector β-catenin act in concert to mediate the positioning of the dynamic interaction with, and spindle orientation to, a localized Wnt3a-source. Wnt-iGluR crosstalk may prove pervasive throughout embryonic and adult stem cell signalling.
Non-national clients in Belgian substance use treatment
Authors: De Kock Charlotte , Blomme Eva , Antoine Jérôme 
Published: June 2020

Purpose
Substance use treatment (SUT) among migrants and ethnic minorities is an underresearched domain in European countries, although preliminary studies point out disparities in treatment use and access compared to general populations. This paper aims to identify the main characteristics of and the types of services solicited by non-nationals in Belgium.

Design/methodology/approach
This paper compares the types of SUT services used by Belgian and non-national clients. Second, the referral source for Belgian and non-national clients is considered. Third, the study compares the client characteristics of Belgian and non-national clients. This descriptive analysis is based on aggregated data sets in the European treatment demand indicator (TDI) registry including all Belgian treatment episodes between 2012 and 2014.

Findings
Non-national clients were more often located in outpatient SUT and were less often referred by general practitioners and hospitals, compared to Belgian clients. Third-country clients appear to have lower socioeconomic statuses (education, employment, housing) than Belgian clients. Non-national youngsters and third-country females appear to be underrepresented in Belgian SUT compared to their presence in the general population. The gender gap is larger among third-country clients than among Belgian clients.

Research limitations/implications
These associations between nationality and solicited services, gender, education, employment, housing and referral document treatment gaps among some non-nationals that require special attention in targeted treatment. In the European context, further research is needed on better monitoring migration background in the European TDI registries.

Practical implications
The overrepresentation of non-nationals in low-threshold opioid substitution treatment services and their underrepresentation in high-threshold residential services requires an in-depth analysis of the core goals of these respective services. Residential services, for instance, should consider how a dominant focus on speech therapy hampers access to treatment for these populations and how access for these populations could be enhanced by modifying or diversifying methods in treatment.

Originality/value
To the best of the authors’ knowledge, this is the first paper that analyses the national indicator in a European TDI data set.
The role of labour migration inflows on R&D and innovation activity: evidence from Russian regions
Authors: Aldieri Luigi , Kotsemir Maxim , Vinci Concetto Paolo 
Published: June 2020

PurposeWhat is the effect of an increase of migration inflows on the R&D and innovative performance of developing countries? The purpose of this paper is to investigate the impact of migration inflows on the R&D and innovation activity (measured as expenditures on R&D and technological innovations) in Russian regions.Design/methodology/approachTo this end, the authors use data on 85 Russian regions for the period 2010-2016 through a multi-region economic geography model. In particular, the authors test the hypothesis about the importance of migration inflows on R&D and technological innovation activity (H1) and the hypothesis about the importance of immigrants’ (incoming migrants) human capital (measured by the education level of incoming migrants) on R&D and innovation activity (H2).FindingsEmpirical findings support the evidence in favour of a positive causal link between innovation and migration inflows. Results of our investigation are important because they suggest useful insights for formulating science and innovation policies in Russia, which is a developing country where the recent policies favouring the technological innovation as the transition period have not yet achieved a satisfying outcome.Originality/valueThis paper increases the knowledge in the field with respect to the existing literature, shedding further light on the migration inflows effects, which is a political topic to manage very relevant in all countries.
The combined effect of perceived organizational injustice and perceived politics on deviant behaviors
Authors: Khattak Mohammad Nisar , Zolin Roxanne , Muhammad Noor 
Published: June 2020

PurposeThe main purpose of this study is to examine the catalytic impact of perceptions of politics in organizations on the relationship between perceived unfairness and deviant behavior at work.Design/methodology/approachTo test the proposed research model, the authors collected field data in a public sector university located in Islamabad Capital Territory, Pakistan. A two-wave questionnaire was distributed to 400 employees. In the first wave, the questionnaire was used to collect data on participants’ perceptions of perceived injustice and organizational politics. After two weeks, the second wave of data collection was conducted by sending another questionnaire to the same respondents to collect data on their organizational and interpersonal deviance.FindingsEmpirical findings revealed that perceived interactional injustice results in interpersonal deviance, and perceived distributive and procedural injustice results in organizational deviance. Moreover, the direct relationship between perceived injustice and deviant behaviors was stronger when the perception of politics factor was high.Originality/valueTo the best of the authors’ knowledge, this study is one of the first to test the detrimental effect of perception of politics on deviance in a public organization in Pakistan.
Assessing the market niche of Eurasian rail freight in the belt and road era
Authors: Zhang Xu , Schramm Hans-Joachim 
Published: June 2020

PurposeThis paper presents an overview of the recent development of Eurasian rail freight in the Belt and Road era and further evaluates its service quality in terms of transit times and transport costs compared to other transport modes in containerised supply chains between Europe and China.Design/methodology/approachA trade-off model of transit time and transport costs based on quantitative data from primary and secondary sources is developed to demonstrate the market niche for Eurasian rail freight vis-a-vis the more established modes of transport of sea, air and sea/air. In a scenario analysis, further cargo attributes influencing modal choice are employed to show for which cargo type Eurasian rail freight service is favourable from a shipper's point of view.FindingsAt present, Eurasian rail freight is about 80% less expensive than air freight with only half of the transit time of conventional sea freight. Our scenario analysis further suggests that for shipping time-sensitive goods with lower cargo value ranging from $US1.23/kg to $US10.89/kg as well as goods with lower time sensitivity and higher value in a range of $US2.46/kg to $US21.78/kg, total logistics costs of Eurasian rail freight service rail is cheaper than all other modes of transport.Practical implicationsAs an emerging competitive solution, Eurasian rail freight demonstrates to be an option beneficial in terms of transport cost, transit time, reliability and service availability, which offers a cost-efficient option enabling shippers to build up agile and more sustainable supply chains between China and Europe.Originality/valueOur study firstly provides a comprehensive assessment of present Eurasian rail freight including a thorough comparison with alternative modes of transport from a shipper's point of view.
Robots in a contagious world
Authors: Bogue Robert 
Published: June 2020

Purpose
This paper aims to show how robotic technology is being used to combat the COVID-19 pandemic.

Design/methodology/approach
Following a short introduction, this discusses the role of robots in the following COVID-related applications: disinfection, checking human temperature, monitoring public places, delivering food and other items, food preparation and personal interactions by telepresence. It concludes with a brief discussion.

Findings
Robots are playing diverse and vital roles. They have helped to reduce the chances of spreading the infection by reducing inter-personal contact; freed-up medical professionals by conducting certain routine teaks; assisted and speeded-up the provision of food and medical supplies; monitored public places; informed the public of the need for social distancing; and allowed those in isolation to remain in contact with friends and family.

Originality/value
This provides a timely account of the use of robots in efforts to ameliorate the impact of the COVID-19 pandemic.
Conceptualizing a pedagogy of wellness for rural district leadership: leading, healing and leading self-healing
Authors: Ryan Antoinette M. 
Published: June 2020

PurposeThis article considers the integration of aspects of mindfulness, social and emotional learning (SEL) and leadership wellness practice as a structure for a pedagogy of wellness in rural schools. Research has demonstrated positive outcomes for K–12 students and teachers as a result of training in practices such as mindfulness and SEL, but there has been less attention toward wellness practices incorporated by educational leaders in their own work. Support of professional and community learning for mindfulness may begin with district and school-based leaders in many communities, who facilitate programs in their schools.Design/methodology/approachThis article explores an emergent pedagogy of wellness, which was developed in a small rural district that applied wellness programming, including mindfulness, with parallel learning experiences for leaders, staff members, students and families.FindingsThrough engagement with multiple local stakeholder groups in integrating themes of SEL, mindfulness and leadership wellness, the pedagogy of wellness emerged as a potential framework for improved organizational health, new conceptualizations of students’ success and opportunities for engagement of families in systemic organization of practices of care.Originality/valueConsideration of the preparation of leadership in wellness practices such as mindfulness is discussed, in light of the necessity to address the care and wellness needs of rural communities, toward the sustainability of the pedagogy of wellness.
William A. Shryer, scientific advertising, habits and motivation research
Authors: Tadajewski Mark 
Published: June 2020

Purpose
This paper examines a neglected stream of literature in marketing theory which engaged with the idea that there was more to consumer behavior than conscious and rational thought.

Design/methodology/approach
This is a close reading of the core themes that appear in William A. Shryer’s work. Linkages are made to other pertinent sources.

Findings
We extend McMahon’s (1972) study and offer a different reading of Shryer’s writing to that proffered in recent commentary by Tadajewski (2019), focusing on the managerial side of Shryer’s publications, connecting this to the theoretically innovative foundations based on normal and abnormal psychology. We respond to the suggestion proposed by McMahon (1972) that Shryer was an early pioneer of motivation research, largely in the affirmative.

Originality/value
We provide an alternative interpretation of Shryer’s writing, connecting this to an emergent “advertising science” and subsequently to contemporary strands of literature that have a “family resemblance” to his contributions. These include salient aspects of motivation research; crowd and habitual behavior; mindlessness and social cognition; and finally, empirical examinations of cumulative value theory.
Ill-being or well-being? Energising international business travellers
Authors: Rattrie Lucy , Kittler Markus 
Published: June 2020

PurposeThe purpose of this qualitative study is to explore well-being experiences of international business travellers (IBTs) and contribute to our understanding of personal and job characteristics as antecedents of ill- or well-being.Design/methodology/approachThe authors’ insights are based on semi-structured in-depth interviews with 32 IBTs assigned to various destinations ranging from single-country travel to global operation. Participants in this study represent a range of traveller personas (regarding demographics, type of work, travel patterns). Thematic analysis is used to reveal new insights.FindingsThe authors’ analysis revealed trip-load (i.e. workload, control, organisational support) and intensity of travel (i.e. frequency, duration and quality) as job characteristics that sit on an energy stimulation continuum, driving work-related outcomes such as stress and burnout or health and well-being. Energy draining and boosting processes are moderated by cognitive flexibility and behavioural characteristics.Practical implicationsFindings represent a framework for managing IBT well-being via adjustments in job and travel characteristics, plus guidance for training and development to help IBTs self-manage.Originality/valueThe insights within this paper contribute to the conversation around how to enhance well-being for IBTs and frequent flyers. The study intends to offer direction as to which specific job, psychological and behavioural characteristics to focus on, introducing a novel framework for understanding and avoiding serious consequences associated with international mobility such as increased stress, burnout and ill-health.
Tourism research progress – a bibliometric analysis of tourism review publications
Authors: Leong Lai-Ying , Hew Teck-Soon , Tan Garry Wei-Han , Ooi Keng-Boon , Lee Voon-Hsien 
Published: June 2020

Purpose
Tourism review (TR) celebrates its 75th anniversary in 2020. The purpose of this paper is to proffer a holistic overview of TR based on bibliometric analyses of the publications from 2001 to 2019.

Design/methodology/approach
The research method entails performance analyses and science mapping analyses on TR. The performance analyses engage a sequence of bibliometric statistics, including citation analysis, most cited authors and papers, most influential and productive authors, countries and institutions to name a few. The authors also used visualization of similarities viewer to perform the science mapping analysis of TR based on co-citations of cited authors, bibliographic couplings of authors and countries and co-occurrences of authors’ keywords from 2001 to 2019 and from 2014 to 2019. To examine the thematic evolution using SciMAT, a de-duplicating process was conducted in which 1,485 keywords were refined to 128 word groups before thematic evolution map and strategic diagrams for the three sub-periods were generated.

Findings
The thematic evolution map revealed ten thematic areas. The key themes of each of these thematic areas are destination studies, tourism destination and hospitality tourism; destination studies, competitiveness and innovations, co-operations and experience tourism; business studies, sports tourism, tourism destination and satisfaction; quality studies, networks, social studies and co-operation; business model and sports tourism; tourism management and tourism destination; political studies, perception and satisfaction; political studies, sustainability studies, social studies and health tourism; behavior, perception and satisfaction; and cultural tourism and tourism destination.

Research limitations/implications
The study has managed to unveil the key trends of publications, authors, affiliations, nations and authors’ keywords. The findings are useful for potential authors to have a quick snapshot of what is expected from and what is happening in TR.

Originality/value
The study serves as a historical record of TR’s publications. It presents comprehensive bibliometric analyses of the publications in TR and identifying the key research trends.
Artificial reefs increase fish abundance in habitat‐limited estuaries
Authors: Folpp Heath R. , Schilling Hayden T. , Clark Graeme F. , Lowry Michael B. , Maslen Ben , Gregson Marcus , Suthers Iain M. 
Published: June 2020

Abstract

Human activities have reduced the carrying capacity of many estuarine systems by degrading and removing habitat. Artificial reefs may increase estuarine rocky‐reef habitat, but our understanding of their ecological impact is limited. In particular, the question of whether fish on artificial structures are produced by the habitat or attracted from nearby natural rocky‐reefs is of concern.

We used baited remote underwater video at artificial reef sites and nearby natural reef sites to investigate the influence of artificial reefs on fish abundance in estuaries with low amounts of natural rocky‐reef. We measured total fish abundance and the abundance of three species of fisheries importance (all in the family Sparidae) before artificial reef deployment (Reefballs®), 1 year after and 2 years after. This design was replicated in three widely separate estuaries over 4 years.

During the 2 years post‐deployment, abundance of Sparidae fish increased on both artificial and natural rocky‐reefs, even when artificial reefs were deployed in different years and seasons. Total fish abundance increased at artificial reef sites with no evidence of change at natural rocky‐reef sites.

Our findings provide evidence that the fish seen on artificial reefs were not attracted from the nearby rocky‐reefs and were likely ‘produced’ by the addition of artificial reefs in these estuaries. Artificial reefs can increase the carrying capacity in these estuaries by providing refuge that would otherwise be unavailable.

Synthesis and applications. The increased fish abundance in three estuaries at both artificial reef and natural reef locations shows that purpose‐built artificial reefs can be used in conjunction with restoration/protection of existing natural habitat, to increase estuarine carrying capacity and fish abundance. This may be for fisheries enhancement or estuarine restoration.