bluuebunny/crossref_metadata_2025_split huggingface dataset:
P945What is the role of late-potentials determined by signal-averaged ECG in predicting flecainide provocative test in brugada pattern?
Authors: Brito J , Cortez-Dias N , Nunes-Ferreira N , Aguiar-Ricardo I , Silva G , Rigueira J , Silverio Antonio P , Rodrigues T , Cunha N , Santos R , Sobral S , Ribeiro J , Carpinteiro L , Pinto F J , Sousa J DE 
Published: June 2020

Abstract

Introduction
The sudden cardiac death risk in Brugada Syndrome (BrS) is higher in patients with spontaneous type 1 pattern. Brugada diagnosis is also established in patients with induced type 1 morphology after provocative test with intravenous administration with a sodium blocker channel. Nevertheless, this group of patients is known to be at a lower risk of SCD, and their risk stratification is still a matter of discussion. Late potentials (LP) detected on signal-averaged ECG (SAECG) on the RVOT have been previously proposed as a predictor factor for BrS, even though data is lacking on its value.
Purpose
To evaluate the association between positive LP (LMS40&gt; 38ms) on SAECG with modified Brugada leads and a positive flecainide test in patients with non-type 1 BrS.
Methods
Retrospective single-center study of non-type 1 BrS patients referred for the performance of a flecainide provocative test. Patients presenting with spontaneous type 1 morphology were excluded from the study. Study of LP on SAECG with modified leads for Brugada were evaluated before administration of flecainide [2mg/kg (maximum150mg), for 10minutes] with determination of filtered QRS duration (fQRS), root mean square voltage of the last 40ms of the QRS complex (RMS40) and duration of low amplitude signals &lt;40μV of the terminal QRS complex (LMS40).
Results
126 patients (47.3 ± 14.1 years, 61.9% males) underwent study with LP SAECG and flecainide test. Among these patients, 7.9% were symptomatic and 16.7% had familiar history of BrS. Flecainide test was positive in 46.8% of patients.
In patients with a positive flecainide test, 64.4% presented LMS40 &gt; 38ms whereas LMS40 &gt; 38ms was present in only 46% of those with a negative flecainide test (p = 0.031). The presence of positive LMS40 was a positive predictor for a positive flecainide test, associated with a two-fold increase likelihood in the induction of a Brugada pattern (OR: 2,12; IC95% 1,025-4,392; P = 0,043).
There was no association between fQRS or RMS40 and a positive flecainide test (p = NS). fQRS &gt; 114ms and RMS40 &lt;20uV was present in 22% and 61% of patients with a positive flecainide test, respectively.

Conclusion
In patient with non-type 1 Brugada syndrome, LMS40 &gt; 38ms in SAECG was a predictor for a positive flecainide test, suggesting that this finding could be helpful on the risk stratification of patients undergoing diagnostic study for Brugada syndrome.
Abstract Figure. Effect of LMS 40 in flecainide test
P1464A question of gender equality. Sex-related differences in survival after primary prevention implantable cardioverter-defibrillator implantation for dilated cardiomyopathy An analysis from POLKARD
Authors: Warchol I , Lubinski A , Sterlinski M , Kowalski O , Goscinska-Bis K , Pytkowski M , Mitkowski P , Kazmierczak J , Szwed H , Przybylski A , Trusz-Gluza M , Kempa M , Zienciuk-Krajka A , Sielski S , Pazdyga A 
Published: June 2020

Abstract

OnBehalf
POLKARD Polish ICD Registry

Background
The protective effects of implantable cardioverter defibrillators (ICDs) in the primary prevention of sudden cardiac death of patients presenting with left ventricular (LV) systolic dysfunction are unequivocal. Nevertheless, female underrepresentation has been a consistent finding in all randomized controlled primary prevention ICD trials. Surprisingly, there is a vast body of literature on female primary prevention ICD patients exhibit a lower overall mortality.

Purpose
Therefore, we analyzed data from a large, nationwide POLKARD registry to evaluate the effect of sex on survival after primary prevention cardioverter-defibrillator implantation for dilated cardiomyopathy.

Methods
All patients enrolled in the Polish ICD Registry from 2008 to 2014 were identified. Patients were included in the study if they were designated as receiving an ICD for primary prevention of SCD after documented non-ischeamic cardiomyopathy. Kaplan-Meier survival analysis was used to assess all-cause mortality.

Results
Of the 964 ICD recipients, 241 (25%) were women (mean age of 64± 0,45 years). During a mean follow-up of 5,53 ± 2,48 years 32% of women and 42% of men died. Kaplan-Meier curve depicted a significantly lower mortality for women than for men (p = 0,05). The median survival time was 6,73 years (55 deaths per 1000 person-years) versus 6,37 years (78 deaths per 1000 person-years) for women and men, respectively.

Conclusions
In agreement with previous studies, our data indicate that primary prevention implantation rates for dilated cardiomyopathy are lower in women. However, the reasons are not entirely understood.
P1369Predictors of atrial fibrillation recurrence after radiofrequency ablation in patients with chronic heart failure with preserved ejection fraction
Authors: Zolotarova T 
Published: June 2020

Abstract
Introduction. Randomized controlled trials and meta-analyzes have shown high efficacy of the radiofrequency ablation (RFA) for both initial and secondary strategies after unsuccessful drug therapy (DT) to maintain sinus rhythm (SR) and improve functional and morphological quality of life; in patients with chronic heart failure (CHF), RFA were associated with a significant relative reduction in the risk of overall mortality, atrial fibrillation (AF) recurrence, and hospitalization for cardiac pathology (compared with DT). High risk of arrhythmia recurrence (up to 45% within 6 - 12 months after intervention) remains a major RFA problem.
Purpose. to evaluate predictive properties of demographic, hemodynamic and electrocardiographic parameters for recurrence after atrial fibrillation ablation in patients with chronic heart failure with preserved ejection fraction.
Methods. We included 120 patients, aged 59.80 ± 10.08 years with CHF with preserved ejection fraction (EF) of left ventricle (LV) who underwent first time RFA for AF with LV EF(&gt; 40%) I-III FC NYHA. Baseline clinical data, ECG before and after the procedure, ECHO parameters were collected
Results Thirty-two patients had AF recurrence after a mean follow-up of twelve months. Those experiencing recurrence were more female (50% vs.39%, p &lt;0,01), had a longer QTc interval before ablation than those without recurrence (387,23 ± 2,31 vs. 341,22 ± 8,91 ms, p &lt; 0,01) and after ablation (439,01 ± 4,73 vs. 373,21 ± 7,92 ms, p &lt; 0,001), lower LV EF (59% vs. 63%, p &lt; 0,05), higher left atrium diameter (4,59 ± 0,45 vs. 4,08 ± 0,61 cm, p &lt; 0,001) and higher mean pulmonary artery gradient (32,86 ± 9,67 vs. 25,15 ± 9,73, p &lt; 0,01).
Conclusions. QTc duration to radiofrequency ablation and its prolongation after intervention are independent predictors of arrhythmia recurrence in patients with chronic heart failure with a preserved left ventricular ejection fraction. The size of the left atrium before ablation is a highly sensitive predictor of recurrence of arrhythmia
P359Outcomes of radiofrequency catheter ablation of ischemic ventricular tachycardia in patients with electrical storm
Authors: Oksul M , Yorgun H , Sener Y Z , Ates A H , Canpolat U , Aytemir K 
Published: June 2020

Abstract

Background
Electrical storm (ES) is defined as 3 or more episodes of sustained ventricular tachycardia (VT) within 24 hours and related with high mortality rates. Catheter ablation is an effective treatment option in patiens with ES.

Purpose

We aimed to evaluate outcomes of VT catheter ablation in patients with ES.

Methods

All patients who underwent catheter ablation due to VT ablation between June 2014 and November 2018 were screened and outcomes of patients who admitted with ES were evaluated.

Results
A total of 128 patients were included. 52 (40.6%) patients were admitted with ES. Mean age of the patients with ES was 68 ± 10,5 years and 48(92,3) patients were male. Median follow up was 22.5 (8-46) months. Baseline characteristics were listed in Table- 1.Multivariate regression analysis revealed that hemoglobin level (HR:0.76, CI:0,61-0,94, p = 0.011 ) and antiarrhythmic drug use (HR:0.25, CI:0,10-0.62, p = 0.003) were predictors of ES development. Recurrence rates and number of re-do ablation procedures were significantly higher in patients with ES (Table-1). Cardiovascular and all cause mortality rates were also significantly higher in patients with ES (Table-1).

Conclusion
Despite catheter ablation is an effective treatment in patients with ES; presence of ES is related with increased mortality and recurrence rates after ablation.
Table-1 Patients with ES Patients without ES p value Age, years 68 ± 10,5 63,8 ± 8,8 0,017* Gender, male, n (%) 48(92,3) 72(94,7) 0,853 Hypetension, n (%) 34(65,4) 59(77,6) 0,158 Diabetes, n (%) 17(32,7) 18(23,7) 0,314 Previous PCI 32(61,5) 51(67,1) 0,574 NYHA &gt;II 17(32,7) 13(17,1) 0,044* LV EF, (%) 27,8 ± 8 29,1 ± 8,3 0,369 LV EDD, mm 64,6 ± 9,1 63,3 ± 8,2 0,431 Hemoglobin, g/dL 13,0 ± 2,1 14,1 ± 1,6 0,002* BNP level (pg/mL) 461(35-3161) 244(10-4517) 0,008* Recurrence 23(44,2) 21(27,6) 0,050* Re-do ablation 0,050* 8(10,5) 0,010* Cardiovascular mortality 16(34,8) 12(16,9) 0,045* All cause mortality 22(42,3) 17(22,4) 0,020* Baseline characteristics and outcomes of catheter ablation in patients with and without ES
Draft genome assemblies using sequencing reads from Oxford Nanopore Technology and Illumina platforms for four species of North American Fundulus killifish
Authors: Johnson Lisa K , Sahasrabudhe Ruta , Gill James Anthony , Roach Jennifer L , Froenicke Lutz , Brown C Titus , Whitehead Andrew 
Published: June 2020

Abstract

Background
Whole-genome sequencing data from wild-caught individuals of closely related North American killifish species (Fundulus xenicus, Fundulus catenatus, Fundulus nottii, and Fundulus olivaceus) were obtained using long-read Oxford Nanopore Technology (ONT) PromethION and short-read Illumina platforms.

Findings
Draft de novo reference genome assemblies were generated using a combination of long and short sequencing reads. For each species, the PromethION platform was used to generate 30–45× sequence coverage, and the Illumina platform was used to generate 50–160× sequence coverage. Illumina-only assemblies were fragmented with high numbers of contigs, while ONT-only assemblies were error prone with low BUSCO scores. The highest N50 values, ranging from 0.4 to 2.7 Mb, were from assemblies generated using a combination of short- and long-read data. BUSCO scores were consistently &gt;90% complete using the Eukaryota database.

Conclusions
High-quality genomes can be obtained from a combination of using short-read Illumina data to polish assemblies generated with long-read ONT data. Draft assemblies and raw sequencing data are available for public use. We encourage use and reuse of these data for assembly benchmarking and other analyses.
A rare complication of myocardial ischaemia following single-stage repair in a case of Berry syndrome
Authors: Duyen Mai Dinh , Haranal Maruti Y , Dillon Jeswant , Sivalingam Sivakumar 
Published: June 2020

Abstract
Berry syndrome is a rare congenital cardiac lesion consisting of a distal aortopulmonary window, the aortic origin of the right pulmonary artery (PA), intact ventricular septum and an interrupted or hypoplastic aortic arch. Different repair techniques have been described in the literature. We report a case of Berry syndrome, in whom myocardial ischaemia developed following direct implantation of the right PA to the main PA, which was resolved using an interposition tube graft.
Development of Hepatocellular Carcinoma in Patients Aged 75–84 Years With Chronic Hepatitis C Treated With Direct-Acting Antivirals
Authors: Ogawa Eiichi , Nomura Hideyuki , Nakamuta Makoto , Furusyo Norihiro , Kajiwara Eiji , Dohmen Kazufumi , Kawano Akira , Ooho Aritsune , Azuma Koichi , Takahashi Kazuhiro , Satoh Takeaki , Koyanagi Toshimasa , Ichiki Yasunori , Kuniyoshi Masami , Yanagita Kimihiko , Amagase Hiromasa , Morita Chie , Sugimoto Rie , Kato Masaki , Shimoda Shinji , Hayashi Jun ,   The Kyushu University Liver Disease Study (KULDS) Group
Published: June 2020

AbstractBackgroundDirect-acting antiviral (DAA) treatment has revolutionized hepatitis C virus (HCV) care. We aimed to evaluate the risk for the development of hepatocellular carcinoma (HCC) in patients aged 75–84 years with chronic hepatitis C after HCV elimination.MethodsThis multicenter cohort study included 2405 consecutive patients with chronic hepatitis C without a history of HCC who achieved HCV elimination by DAAs. Patients in whom HCC developed within 1 year of DAA initiation were excluded. Propensity score matching analysis was used to evaluate differences in HCC risk between patients aged 75–84 versus 60–74 years.ResultsThe median observational period was 3.5 years. Among patients aged 75–84 years with a high Fibrosis-4 (FIB-4) index (≥3.25 at baseline), there was no significant difference in the annual incidence of HCCs between groups with an FIB-4 index ≥3.25 (2.75 per 100 person-years [PY]) versus &lt;3.25 (2.16 per 100 PY) at 12 weeks after the end of treatment, unlike the results in those aged 60–74 years (3.61 and 1.51 per 100 PY, respectively) (adjusted hazard ratio, 2.20; P = .04). In 495 pairs matched by propensity score matching, in patients without cirrhosis, the cumulative HCC incidence was significantly higher in the 75–84-year than in the 60–74-year age group (P = .04).ConclusionsOlder patients aged 75–84 years remained at high risk for the development of HCC, even after HCV elimination and the improvement of the FIB-4 index to &lt;3.25.
Emergence of vancomycin- and teicoplanin-resistant Enterococcus faecium via vanD5-harbouring large genomic island
Authors: Sato Toyotaka , Wada Takayuki , Shinagawa Masaaki , Fukushima Yukari , Nakajima Chie , Suzuki Yasuhiko , Takahashi Satoshi , Yokota Shin-ichi 
Published: June 2020

Abstract

Background
Treatment of VRE is of clinical concern. While certain numbers of vanD-type VRE have been isolated, only two vanD5-harbouring Enterococcus faecium isolates have been reported in Canada and Japan.

Methods
We report the isolation of vanD5-type E. faecium and the first ever determination of the whole-genome sequence to investigate the possible mechanisms of the acquisition of the vanD5 gene cluster in E. faecium.

Results
Two vanD5-harbouring vancomycin-resistant E. faecium were isolated from the skin (SMVRE19) and faeces (SMVRE20) of a patient with a skin ulcer in Japan. The isolates exhibited vancomycin and teicoplanin MIC values of 128 mg/L, whilst the previous isolates of vanD5-harbouring E. faecium were only resistant to vancomycin. SMVRE19 and SMVRE20 were clones related to ST18, which is also seen in vanA- and vanB-type VRE. These isolates harboured an insertion element, ISEfm1, in the ddl gene, similar to a previously described teicoplanin-resistant vanD3-type E. faecium. The vanD5 gene cluster was integrated into the SMVRE20 chromosome as a part of a large genomic island (approximately 127 kb), similar to other recently spreading vanD variants in the Netherlands. The genomic island shared the greatest similarity with a part of the Blautia coccoides genome sequence, except for the region surrounding the vanD gene cluster.

Conclusions
This study reports that emergence of vancomycin- and teicoplanin-resistant vanD5-type E. faecium occurred via acquisition of the vanD5 cluster and ISEfm1 insertion into ddl. Considering the genetic similarity between the various VRE strains, the current study should serve as a warning against the spread of vanD5-type VRE.
How consumption and repulsion set planetary gap depths and the final masses of gas giants
Authors: Rosenthal M M , Chiang E I , Ginzburg S , Murray-Clay R A 
Published: June 2020

ABSTRACT
Planets open gaps in discs. Gap opening is typically modelled by considering the planetary Lindblad torque which repels disc gas away from the planet’s orbit. But gaps also clear because the planet consumes local material. We present a simple, easy-to-use, analytic framework for calculating how gaps deplete and how the disc’s structure as a whole changes by the combined action of Lindblad repulsion and planetary consumption. The final mass to which a gap-embedded gas giant grows is derived in tandem. The analytics are tested against 1D numerical experiments and calibrated using published multidimensional simulations. In viscous alpha discs, the planet, while clearing a gap, initially accretes practically all of the gas that tries to diffuse past, rapidly achieving super-Jupiter if not brown dwarf status. By contrast, in inviscid discs – that may still accrete on to their central stars by, say, magnetized winds – planets open deep, repulsion-dominated gaps. Then only a small fraction of the disc accretion flow is diverted on to the planet, which grows to a fraction of a Jupiter mass. Transitional disc cavities might be cleared by families of such low-mass objects opening inviscid, repulsion-dominated, overlapping gaps which allow most of the outer disc gas to flow unimpeded on to host stars.
On the spin-up events and spin direction of the X-ray pulsar GX 301-2
Authors: Liu Jiren 
Published: June 2020

ABSTRACT
Recently, a retrograde neutron star is proposed for the classical wind-fed X-ray pulsar, GX 301-2, to explain the orbital spin-up to spin-down reversal near periastron, based on the stream model invoked to explain the pre-periastron flare of GX 301-2 previously. We study in detail three rare spin-up events detected by Fermi/GBM and find that the spin derivatives are correlated with the Swift/BAT fluxes, following a relation of $\dot{\nu }\propto F^{0.75\pm 0.05}$. All the spin-up events of GX 301-2 started about 10 d after the periastron, which is the time needed for tidally stripped gas to reach the neutron star. The slow rotation of the optical companion implies that the accreted matter is likely to have angular momentum in the direction of the orbital motion, as in a Roche lobe-like overflow. As a result, the spin-up events of GX 301-2 would favour accretion of a prograde disc to a prograde neutron star. We also find that the flare of intrinsic X-ray emission of GX 301-2 happened 0.4 d before periastron, while the flare of low-energy emission (2–10 keV) happened about 1.4 d before periastron. The preceding low-energy flare can be explained by stronger absorption of the intrinsic X-ray emission closer to the periastron. This finding weakened the need of the stream model. The pulse fraction of GX 301-2 near periastron is reduced heavily, which is likely caused by Compton-scattering process. Compton reflection from the optical companion might be responsible for the observed orbital spin reversal of GX 301-2.
Aspects of the Real Numbers: Putnam, Wittgenstein, and Nonextensionalism
Authors: Floyd Juliet 
Published: June 2020

AbstractI defend Putnam’s modal structuralist view of mathematics but reject his claims that Wittgenstein’s remarks on Dedekind, Cantor, and set theory are verificationist. Putnam’s “realistic realism” (1990–2016) showcases the plasticity of our “fitting” words to the world. The applications of this—in philosophy of language, mind, logic, and philosophy of computation—are robust. I defend Wittgenstein’s nonextensionalist understanding of the real numbers, showing how it fits Putnam’s view. Nonextensionalism and extensionalism about the real numbers are mathematically, philosophically, and logically robust, but the two perspectives are often confused with one another. I separate them, using Turing’s work as an example.
Eukaryotic life without tQCUG: the role of Elongator-dependent tRNA modifications in Dictyostelium discoideum
Authors: Schäck Manfred A , Jablonski Kim Philipp , Gräf Stefan , Klassen Roland , Schaffrath Raffael , Kellner Stefanie , Hammann Christian 
Published: June 2020

Abstract
In the Elongator-dependent modification pathway, chemical modifications are introduced at the wobble uridines at position 34 in transfer RNAs (tRNAs), which serve to optimize codon translation rates. Here, we show that this three-step modification pathway exists in Dictyostelium discoideum, model of the evolutionary superfamily Amoebozoa. Not only are previously established modifications observable by mass spectrometry in strains with the most conserved genes of each step deleted, but also additional modifications are detected, indicating a certain plasticity of the pathway in the amoeba. Unlike described for yeast, D. discoideum allows for an unconditional deletion of the single tQCUG gene, as long as the Elongator-dependent modification pathway is intact. In gene deletion strains of the modification pathway, protein amounts are significantly reduced as shown by flow cytometry and Western blotting, using strains expressing different glutamine leader constructs fused to GFP. Most dramatic are these effects, when the tQCUG gene is deleted, or Elp3, the catalytic component of the Elongator complex is missing. In addition, Elp3 is the most strongly conserved protein of the modification pathway, as our phylogenetic analysis reveals. The implications of this observation are discussed with respect to the evolutionary age of the components acting in the Elongator-dependent modification pathway.
Risk Factors for Candidemia After Open Heart Surgery: Results From a Multicenter Case–Control Study
Authors: Giacobbe Daniele Roberto , Salsano Antonio , Del Puente Filippo , Miette Ambra , Vena Antonio , Corcione Silvia , Bartoletti Michele , Mularoni Alessandra , Maraolo Alberto Enrico , Peghin Maddalena , Carnelutti Alessia , Losito Angela Raffaella , Raffaelli Francesca , Gentile Ivan , Maccari Beatrice , Frisone Stefano , Pascale Renato , Mikus Elisa , Medaglia Alice Annalisa , Conoscenti Elena , Ricci Davide , Lupia Tommaso , Comaschi Marco , Giannella Maddalena , Tumbarello Mario , De Rosa Francesco Giuseppe , Del Bono Valerio , Mikulska Malgorzata , Santini Francesco , Bassetti Matteo 
Published: June 2020

Abstract

Background
Candida species are among the most frequent causative agents of health care–associated bloodstream infections, with mortality &gt;40% in critically ill patients. Specific populations of critically ill patients may present peculiar risk factors related to their reason for intensive care unit admission. The primary objective of the present study was to assess the predictors of candidemia after open heart surgery.

Methods
This retrospective, matched case–control study was conducted in 8 Italian hospitals from 2009 to 2016. The primary study objective was to assess factors associated with the development of candidemia after open heart surgery.

Results
Overall, 222 patients (74 cases and 148 controls) were included in the study. Candidemia developed at a median time (interquartile range) of 23 (14–36) days after surgery. In multivariable analysis, independent predictors of candidemia were New York Heart Association class III or IV (odds ratio [OR], 23.81; 95% CI, 5.73–98.95; P &lt; .001), previous therapy with carbapenems (OR, 8.87; 95% CI, 2.57–30.67; P = .001), and previous therapy with fluoroquinolones (OR, 5.73; 95% CI, 1.61–20.41; P = .007). Crude 30-day mortality of candidemia was 53% (39/74). Septic shock was independently associated with mortality in the multivariable model (OR, 5.64; 95% CI, 1.91–16.63; P = .002). No association between prolonged cardiopulmonary bypass time and candidemia was observed in this study.

Conclusions
Previous broad-spectrum antibiotic therapy and high NYHA class were independent predictors of candidemia in cardiac surgery patients with prolonged postoperative intensive care unit stay.