bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of compaction and heat treatment on the soft magnetic properties of iron-based soft magnetic composites
Authors: Pan Yifan , Peng Jingguang , Qian Liwei , Xiang Zhen , Lu Wei 
Published: January 2020

Abstract
Iron-based soft magnetic composites (SMCs) are promising substitutes for laminate steels in electromagnetic applications due to their excellent magnetic properties and productivity. However, the preparation process is a key factor in deciding the magnetic performance of SMCs. In this work, the Fe-based soft magnetic composites with improved soft magnetic properties were achieved by optimizing the compaction and the annealing process. Results showed that the core–shell structure of powders which would directly have an impact on the permeability and the core loss of the SMCs could be affected by the compaction and the annealing process. In addition, the magnetic properties were enhanced by tuning the microstructure. As a result, the optimal magnetic performance of the compact with high permeability and low total core loss was obtained. The real part of the permeability of the soft magnetic composites could reach a maximal value of 336.8 and a rather low core loss of 2.5 W Kg−1 (measured at 50 mT and 5 kHz). Therefore, soft magnetic composites with enhanced magnetic properties were obtained by optimizing the powder metallurgy (PM) process in this study.
Elastic properties of single crystal Bi12SiO20 as a function of pressure and temperature and acoustic attenuation effects in Bi12MO20 (M = Si, Ge and Ti)
Authors: Haussühl Eiken , Reichmann Hans Josef , Schreuer Jürgen , Friedrich Alexandra , Hirschle Christian , Bayarjargal Lkhamsuren , Winkler Björn , Alencar Igor , Wiehl Leonore , Ganschow Steffen 
Published: January 2020

Abstract
A comprehensive study of sillenite Bi12SiO20 single-crystal properties, including elastic stiffness and piezoelectric coefficients, dielectric permittivity, thermal expansion and molar heat capacity, is presented. Brillouin-interferometry measurements (up to 27 GPa), which were performed at high pressures for the first time, and ab initio calculations based on density functional theory (up to 50 GPa) show the stability of the sillenite structure in the investigated pressure range, in agreement with previous studies. Elastic stiffness coefficients c
11 and c
12 are found to increase continuously with pressure while c
44 increases slightly for lower pressures and remains nearly constant above 15 GPa. Heat-capacity measurements were performed with a quasi-adiabatic calorimeter employing the relaxation method between 2 K and 395 K. No phase transition could be observed in this temperature interval. Standard molar entropy, enthalpy change and Debye temperature are extracted from the data. The results are found to be roughly half of the previous values reported in the literature. The discrepancy is attributed to the overestimation of the Debye temperature which was extracted from high-temperature data. Additionally, Debye temperatures obtained from mean sound velocities derived by Voigt-Reuss averaging are in agreement with our heat-capacity results. Finally, a complete set of electromechanical coefficients was deduced from the application of resonant ultrasound spectroscopy between 103 K and 733 K. No discontinuities in the temperature dependence of the coefficients are observed. High-temperature (up to 1100 K) resonant ultrasound spectra recorded for Bi12
MO20 crystals revealed strong and reversible acoustic dissipation effects at 870 K, 960 K and 550 K for M = Si, Ge and Ti, respectively. Resonances with small contributions from the elastic shear stiffness c
44 and the piezoelectric stress coefficient e
123 are almost unaffected by this dissipation.
About the surface area to volume relations of open cell foams
Authors: August A , Nestler B 
Published: January 2020

Abstract
Many useful applications of solid open-cell foams make use of their enormous surface, compared to their volume. The large surface is accompanied by a large interface between foam and filling of a fluid, gas or another solid forming a composite material. Due to the large interface, heat exchange between the involved materials takes place in a particularly efficient manner making open cell metallic foams to base materials for heat exchange and heat systems of increasing importance. But what is the mathematical connection between the solid bulk volume fraction and the surface of these porous materials? This question is investigated through the evaluation of 5000 synthetic, randomly generated open-cell cellular structures of different material ratios.
Smoking-Related Risks of Colorectal Cancer by Anatomical Subsite and Sex
Authors: Gram Inger T , Park Song-Yi , Wilkens Lynne R , Haiman Christopher A , Le Marchand Loïc 
Published: January 2020

Abstract
The purpose of this study was to examine whether the increased risk of colorectal cancer due to cigarette smoking differed by anatomical subsite or sex. We analyzed data from 188,052 participants aged 45–75 years (45% men) who were enrolled in the Multiethnic Cohort Study in 1993–1996. During a mean follow-up period of 16.7 years, we identified 4,879 incident cases of invasive colorectal adenocarcinoma. In multivariate Cox regression models, as compared with never smokers of the same sex, male ever smokers had a 39% higher risk (hazard ratio (HR) = 1.39, 95% confidence interval (CI): 1.16, 1.67) of cancer of the left (distal or descending) colon but not of the right (proximal or ascending) colon (HR = 1.03, 95% CI: 0.89, 1.18), while female ever smokers had a 20% higher risk (HR = 1.20, 95% CI: 1.06, 1.36) of cancer of the right colon but not of the left colon (HR = 0.96, 95% CI: 0.80, 1.15). Compared with male smokers, female smokers had a greater increase in risk of rectal cancer with number of pack-years of smoking (P for heterogeneity = 0.03). Our results suggest that male smokers are at increased risk of left colon cancer and female smokers are at increased risk of right colon cancer. Our study also suggests that females who smoke may have a higher risk of rectal cancer due to smoking than their male counterparts.
Flexibly Accounting for Exposure Misclassification With External Validation Data
Authors: Edwards Jessie K , Cole Stephen R , Fox Matthew P 
Published: January 2020

Abstract
Measurement error is common in epidemiology, but few studies use quantitative methods to account for bias due to mismeasurement. One potential barrier is that some intuitive approaches that readily combine with methods to account for other sources of bias, like multiple imputation for measurement error (MIME), rely on internal validation data, which are rarely available. Here, we present a reparameterized imputation approach for measurement error (RIME) that can be used with internal or external validation data. We illustrate the advantages of RIME over a naive approach that ignores measurement error and MIME using a hypothetical example and a series of simulation experiments. In both the example and simulations, we combine MIME and RIME with inverse probability weighting to account for confounding when estimating hazard ratios and counterfactual risk functions. MIME and RIME performed similarly when rich external validation data were available and the prevalence of exposure did not vary between the main study and the validation data. However, RIME outperformed MIME when validation data included only true and mismeasured versions of the exposure or when exposure prevalence differed between the data sources. RIME allows investigators to leverage external validation data to account for measurement error in a wide range of scenarios.
Development and perception of a multiple-site nontraditional postgraduate year 1 residency program
Authors: Hawkins Smith Carla , Stevens Joanie Spiro , Rosa Morales Leslie , Martinez Leyner , Camejo Madeline , Bryant Keysha 
Published: January 2020

Abstract

Purpose
To describe the development and perception of a multiple-site nontraditional postgraduate year 1 (PGY1) residency program from the resident and preceptor perspectives.

Summary
A multiple-site nontraditional residency program was developed within a Florida health system to increase the education level and clinical responsibilities of hospital staff pharmacists. The program provided pharmacists interested in residency training an opportunity to pursue postgraduate credentials while maintaining their current position. The nontraditional residency program was implemented at 1 site and subsequently expanded across multiple affiliated hospital sites due to its success. Pharmacists currently working in the health system’s network of hospitals for at least 2 years were eligible to enter into the 24-month program after successfully completing the application, interview, and matching process. The number of nontraditional resident positions available has varied by residency year and site. Offering this opportunity has increased the clinical knowledge of pharmacists, exposed them to a variety of practice areas, and increased their departmental contributions. In response to a request for feedback regarding the multiple-site nontraditional program, both residents and preceptors have reported benefits and challenges.

Conclusion
Adequate resources are needed and a number of factors must be considered in developing a multiple-site nontraditional PGY1 residency program. Although there are potential challenges, it is perceived that the benefits justify continuation of the program.
Bias due to Berkson error: issues when using predicted values in place of observed covariates
Authors: Haber Gregory , Sampson Joshua , Graubard Barry 
Published: January 2020

Summary
Studies often want to test for the association between an unmeasured covariate and an outcome. In the absence of a measurement, the study may substitute values generated from a prediction model. Justification for such methods can be found by noting that, with standard assumptions, this is equivalent to fitting a regression model for an outcome variable when at least one covariate is measured with Berkson error. Under this setting, it is known that consistent or nearly consistent inference can be obtained under many linear and nonlinear outcome models. In this article, we focus on the linear regression outcome model and show that this consistency property does not hold when there is unmeasured confounding in the outcome model, in which case the marginal inference based on a covariate measured with Berkson error differs from the same inference based on observed covariates. Since unmeasured confounding is ubiquitous in applications, this severely limits the practical use of such measurements, and, in particular, the substitution of predicted values for observed covariates. These issues are illustrated using data from the National Health and Nutrition Examination Survey to study the joint association of total percent body fat and body mass index with HbA1c. It is shown that using predicted total percent body fat in place of observed percent body fat yields inferences which often differ significantly, in some cases suggesting opposite relationships among covariates.
Generalized additive regression for group testing data
Authors: Liu Yan , McMahan Christopher S , Tebbs Joshua M , Gallagher Colin M , Bilder Christopher R 
Published: January 2020

Summary
In screening applications involving low-prevalence diseases, pooling specimens (e.g., urine, blood, swabs, etc.) through group testing can be far more cost effective than testing specimens individually. Estimation is a common goal in such applications and typically involves modeling the probability of disease as a function of available covariates. In recent years, several authors have developed regression methods to accommodate the complex structure of group testing data but often under the assumption that covariate effects are linear. Although linearity is a reasonable assumption in some applications, it can lead to model misspecification and biased inference in others. To offer a more flexible framework, we propose a Bayesian generalized additive regression approach to model the individual-level probability of disease with potentially misclassified group testing data. Our approach can be used to analyze data arising from any group testing protocol with the goal of estimating multiple unknown smooth functions of covariates, standard linear effects for other covariates, and assay classification accuracy probabilities. We illustrate the methods in this article using group testing data on chlamydia infection in Iowa.
Civic Crowdfunding for Social Work Research: Opportunities, Challenges and Strategies
Authors: Cheung Johnson Chun-Sing , Rogers Justin Mark 
Published: January 2020

Abstract
Civic crowdfunding for research purposes has been an emerging trend in scientific fields over the past few years. This article presents findings from a mixed methods analysis of 152 social science research projects that campaigned for crowdfunding. A total of US$583,074 was raised through the support of 6,663 backers amongst the 150 successfully funded projects. This study offers specific lessons for social work researchers engaging in crowdfunding campaigns. The data show that projects supported by endorsers and initiated by faculties were able to solicit more backers and funds. Another key finding is that the campaigns that had videos for promotional purposes were the most successful, but video length does not affect backers’ consideration. The article presents the potential ethical challenges for social work researchers in this crowdfunding arena. In what may first appear to be a democratic and emancipatory space, decisions are actually made about what topics are worthy of financing by people who have access to the online platforms and the disposable income to back the project. Nevertheless, these platforms offer a route to research funding for academics, practitioners and service user groups in a context where funding from research councils and foundations is increasingly limited and competitive.
A new look at the role of urinalysis in the history of diagnostic medicine
Authors: White William I 
Published: January 2020

Abstract
Before this century, urine was the predominant body fluid used by the physician for diagnosis and prognosis. Uroscopy, or urinalysis by the senses, has usually been treated disparagingly in historical accounts of diagnostic medicine. Although uroscopy was at times used fraudulently, the thoughtful use of urinalysis was probably an important part of diagnosis for the physician, even before the chemical analysis of urine.
Capillary electrophoresis--a new clinical tool
Authors: Chen Fu-TalA , Liu Cheng-Ming , Hsieh You-Zun , Sternberg James C 
Published: January 2020

Abstract
The potential clinical diagnostic utility of capillary electrophoresis in an open-tubular column is established. Separation patterns for serum proteins by conventional agarose gel electrophoresis can be faithfully reproduced by a capillary electrophoresis procedure that provides the complete run data in 8 min. Hemoglobin variants can be separated within 10 min. The capillary electrophoresis separations are performed reliably and reproducibly in an untreated 75 micron (i.d.) x 25 cm fused-silica column. Diluted serum or hemoglobin samples can be loaded on an automated instrument with on-line injection, detection, and quantification, providing a truly "walkaway" electrophoresis system.
Microparticle-enhanced nephelometric immunoassay (Nephelia) for immunoglobulins G, A, and M
Authors: Cuilliere M L , Montagne P , Bessou Th , el Omari R , Riochet D , Varcin P , Laroche P , Prud'homme Ph , Marchand J , Flecheux O , Pau B , Duheille J 
Published: January 2020

Abstract
Covalent binding of gamma chains of IgG, whole IgA, and mu chains of IgM on polyfunctional hydrophilic microspheres (MS) yields MS-Ig conjugates, usable as reagents in new microparticle-enhanced nephelometric immunoassays (Nephelia). The principle of the assays is inhibition by free analyte (IgG, IgA, and IgM) of agglutination of the MS-Ig conjugate with specific antiserum, the light scattered by the aggregates being measured with a nephelometer. The immunoglobulin assays developed are easy to perform (single-step assays, no washing or phase separation) and sensitive (high dilution of biological samples to exclude interferences and pretreatment). Analytical recovery results (95.4-101.2%) and correlations with generally used commercial assays (r = 0.86-0.98) indicate that the assays are accurate for large concentration ranges of immunoglobulins. Precision sxtudy gives CVs = 2.8-9.6%. Nephelia appears to be useful for quantifying a large variety of biological molecules.
Carbonic anhydrase III in serum in muscular dystrophy and other neurological disorders: relationship with creatine kinase
Authors: Ohta Mitsuhlro , Itagaki Yasuko , Itoh Nobuyukl , Hayashi Kyozo , Nishitani Hirosh , Ohta Klyoe 
Published: January 2020

Abstract
We measured with a radioimmunoassay the concentrations of carbonic anhydrase III (CA-III, EC 4.2.1.1) in sera from 68 patients with muscular dystrophy, 10 carriers of Duchenne muscular dystrophy (DMD), and 63 patients with other neurological disorders. The values obtained were compared with those for creatine kinase (CK, EC 2.7.3.2). Serum CA-III was strikingly increased in patients with DMD (mean, 274.4 micrograms/L) and congenital (Fukuyama-type) (182.8 micrograms/L) and limb-girdle (203.7 micrograms/L) dystrophies and positively correlated with the activities of CK in patients with DMD. CA-III concentration decreased with the subjects' age and the severity of the disease, similar to the tendency observed between age or severity and the concentration of CK. We found moderately increased CA-III in patients with polymyositis, myotonic dystrophy, amyotrophic lateral sclerosis, spinal progressive muscular atrophy, or Kugelberg-Welander disease and in carriers of DMD.
Human anti-murine antibody interference in measurement of carcinoembryonic antigen assessed with a double-antibody enzyme immunoassay
Authors: Price Theresa , Beatty Barbara G , Beatty J David , McNally Alan J 
Published: January 2020

Abstract
Fifty-eight plasma specimens from 30 patients who had undergone presurgical radioimmunoscintigraphy with 111In-labeled anti-carcinoembryonic antigen (CEA) murine monoclonal antibody (Mab) and who had no clinical evidence of disease after surgical resection showed increased concentrations of CEA (greater than or equal to 5 micrograms/L) in plasma when studied with the previously available commercial CEA enzyme immunoassay (EIA) from Roche. The possible role of anti-murine antibody (HAMA) interference was addressed by adding mouse IgG (mIgG) to the plasma (2 g/L) before assay. Fifteen specimens (26%) showed no change in CEA (reflecting a true increase as shown by the original results), 22 (38%) showed a decrease in CEA of greater than 15% but remained positive (reflecting an artefactual increase), and 21 (36%) became CEA-negative (less than or equal to 5 micrograms/L; reflecting a false increase). Subsequently, we assayed the same samples with a modified version of this CEA EIA kit and 47 specimens remained CEA positive (greater than 5 micrograms/L): 25 (53%) were truly increased, 12 (26%) remained artefactually increased, and 10 (21%) continued to show a false increase. The degree of interference in the original EIA kit correlated with the plasma concentration of HAMA (P less than 0.005). All artefactually and falsely increased CEA values observed in both kits were corrected by addition of polyclonal mIgG or of a mixture of IgG1, IgG2a, and IgG2b Mabs before assay. This correction is important in the follow-up of patients who receive murine Mabs for treatment or diagnosis.
Diagnostic and genetic studies in 43 patients with classic cystinuria
Authors: Byrd DennIs J , Lind Marion , Brodehl Johannes 
Published: January 2020

Abstract
We present results for laboratory screening and diagnostic tests--cyanide-nitroprusside test, semi-quantitative thin-layer chromatography, and quantitative amino acid column chromatography--of 43 patients with classic cystinuria. We report the efficaciousness of the cyanide-nitroprusside test and of thin-layer chromatography, as compared with quantitative amino acid chromatography, for detecting heterozygotes for type II or III cystinuria. The quantitative results for aminoaciduria in 57 blood relatives in 23 families were used to categorize the index patients with classic cystinuria. By column chromatography the ranges of excretion rates (mumol/24 h per 1.73 m2 body surface area) of diagnostic amino acids in the index patients were as follows: cystine 556-54044 (normal 20-128), arginine 131-11543 (10-80), lysine 768-21848 (51-514), ornithine 185-5685 (0-80). Also by column chromatography the median values for arginine and ornithine excretion in cystine-lysinuric heterozygotes (among the 57 blood relatives) were significantly higher (P less than 0.01) than in controls but never approached the values for homozygotes. The cyanide-nitroprusside test results were positive in urine samples of 41 of 43 index patients and in 16 (51.6%) of the urine samples of 31 obligate heterozygotes with column chromatographically proven cystine-lysinuria. Thin-layer chromatography detected all of the homozygotes, all the compound heterozygotes, and 54.8% of the carriers. According to the type of aminoaciduria in their relatives, 11 patients with classic cystinuria could be classified as having classic cystinuria type I, 11 as having type II or III, and three as being compound heterozygotes. We discuss the implications of these results for correct diagnoses and for genetic studies in classic cystinuria.
International Federation of Clinical Chemistry standardization project for measurements of apolipoproteins A-I and B
Authors: Marcovina S M , Albers J J , Dati F , Ledue T B , Ritchie R F 
Published: January 2020

Abstract
To minimize differences in apolipoprotein measurements among laboratories and methods, a standardization program involving common suitable reference material is needed. The Committee on Apolipoproteins of the International Federation of Clinical Chemistry initiated a collaborative study for the standardization of test systems for measuring apolipoproteins (apo) A-I and B, with 25 company laboratories and three research laboratories involved in apolipoprotein analysis to: (a) evaluate calibration differences among the test systems; (b) evaluate whether comparability of the data can be achieved with the use of frozen serum pools to recalibrate the different systems; and (c) evaluate and select suitable candidate reference material. We used 26 test systems for apo A-I and 28 for apo B. Relatively modest differences were found in calibration for apo A-I, but very wide differences were observed for apo B methods. After uniform calibration, the overall among-laboratory CV for apo B decreased from 19% to 6%. Three lyophilized serum preparations for apo A-I and three liquid-stabilized serum preparations for apo B were selected for further evaluation as candidate international reference materials.