bluuebunny/crossref_metadata_2025_split huggingface dataset:
88 Severe tricuspid regurgitation due to papillary muscle rupture: A rare complication of anterior myocardial infarction and ventricular septal perforation
Authors: Nagumo M , Wada S , Saitou T , Li H , Sakai T , Iwanaga S 
Published: January 2020

Abstract

INTRODUCTION
Papillary muscle rupture (PMR) of the mitral valve is a fatal complication of acute myocardial infarction (MI). As a complication of anterior MI, PMR of the tricuspid valve is extremely rare. We experienced a case of acute anterior MI complicated with tricuspid PMR and ventricular septal perforation (VSP).
REPORT
An 85-year-old woman was admitted with general fatigue and appetite loss. Her consciousness was alert, but she was pale, and had cold extremities. Her blood pressure was 74/62 mmHg, and pulse was 99/min. There was no leg edema. Pan systolic regurgitant murmur (Levine III/VI) was audible at the lower left sternal border. Her oxygen saturation was 86% under room air. Electrocardiogram revealed ST segment elevation and QS pattern in V1 to V3. Transthoracic echocardiography revealed dyskinesis of the apical anterior septum, VSP with bidirectional shunt, and severe pulmonary hypertension. Left ventricular ejection fraction was preserved (58%). The anterior tricuspid leaflet was flail due to PMR, resulting in severe tricuspid regurgitation and right ventricular dilatation. Coronary angiography revealed a single vessel disease of the left anterior descending artery (LAD). We recommended surgical treatment, and transferred her to another hospital.

DISCUSSION
Common causes of tricuspid PMR are infective endocarditis and chest trauma. Right ventricular infarction, usually caused by right coronary artery (RCA) occlusion, may cause tricuspid PMR. In our case, however, tricuspid PMR was complicated with anterior MI. The tricuspid anterior, posterior, and septal leaflets are attached to anterolateral RV wall, inferior septum, and infundibular septum, respectively, via papillary muscles. Right ventricular branches and septal branches of the RCA usually supply these papillary muscles. Anterior leaflet PMR in this case was possibly due to anomalous blood supply of anterolateral RV wall by the right ventricular branches of the LAD. Right ventricular overload due to large VSP shunt elevated RV diastolic pressure and right atrial pressure, and might worsen ischemia of the RV wall.
Abstract 88 Figure. severe TR & shunt flow through VSP
101 Semi-automated volume-strain loops: a new tool in TTE to assess diastolic dysfunction
Authors: Hubert A , Le Rolle V , Galli E , Hernandez A , Donal E 
Published: January 2020

Abstract

AIM
This work aims to evaluate a novel semi-automatic tool for the assessment of volume-strain loops by transthoracic echocardiography (TTE).

METHOD
17 patients with proved cardiac amyloidosis and 18 patients with heart failure with preserved ejection fraction (HFpEF) were compared to 19 controls, from a local database. All TTE were performed using Vivid E95 ultrasound system (General Electrics Healthcare, Horten, Norway). The complete method includes several steps: 1) extraction of LV strain full traces from apical 4 and 2 cavities views, 2) estimation of LV volume from these two traces by spline interpolations, 3) resampling of LV strain curves, determined for the same cardiac beat, (in apical 4-, 2- and 3- cavities views) as a function of pre-defined percentage increments of LV-volume and 4) calculation of the LV volume-strain loop area. (Figure 1, panel A)
RESULTS (Table 1): LVEF was similar between all groups whereas global longitudinal strain was significantly lower in amyloidosis group than controls (-14.4 vs -20.5%; p &lt; 0.001). HFpEF and amyloidosis groups had a worse diastolic function than controls with a greater left atrial volume index , a faster tricuspid regurgitation, a greater E/e’ ratio with a p &lt; 0.001 for all these indices. Simultaneously, the global area of volume-strain loop was significantly lower in HFpEF and amyloidosis group than controls (72 vs 36 vs 120.0 %.mL, respectively, p &lt; 0.0001) with an intermediate profile of HFpEF(Figure 1, panel B, HFpEF in green). This area was better correlated with mean e’ (r = 0.650, p &lt; 0.001) than all other indices.

CONCLUSION
LV volume-strain loop area appears a very promising new tool to assess semi-automatically diastolic function.
Main echocardiographic results Controls n = 19 HFpEF n = 18 Amyloidosis n = 17 p-value LVEDV (mL) 105 ± 15 103 ± 30 95 ± 93 0.476 LVEF (%) 65 ± 5 62 ± 7 62 ± 7 0.196 GLS (%) -20.5 ± 1.8 -18.4 ± 4.3 -14.4 ± 3.8 &lt;0.0001 LAVi (ml.m-2) 22 ± 5 51 ± 14 51 ± 22 &lt;0.0001 E/A ratio 2.1 ± 0.4 1.2 ± 0.7 1.7 ± 1.0 0.005 Mitral E/Ea average 5.9 ± 1.4 13.7 ± 5.8 17.3 ± 5.4 &lt;0.0001 Vmax TR (m/s) 2.0 ± 0.3 3.1 ± 0.4 2.7 ± 0.5 &lt;0.0001 V-S loop area (ml.%) 120 ± 54 72 ± 45 37 ± 21 &lt;0.0001
Abstract 101 Figure 1
102 Different mechanics of septal and lateral walls and their effects on left ventricular ejection fraction in patients with left bundle-branch block
Authors: Kupczynska K , Nguyen K A , Surkova E , Palermo C H , Sambugaro F , Previtero M , Badano L P , Muraru D 
Published: January 2020

Abstract

Funding Acknowledgements
Karolina Kupczynska was supported by research grant awarded by the Club 30 of the Polish Cardiac Society

Background
Left bundle branch block (LBBB) impairs left ventricular (LV) mechanics and can lead to systolic dysfunction. However, LV mechanical changes that differentiate LBBB patients with preserved and reduced LV ejection fraction (LVEF) remain to be clarified.

Purpose
To measure myocardial work (MWI) and myocardial work efficiency (MWE) of the septal and LV lateral wall in patients with LBBB and various degrees of LV dysfunction using non-invasive strain-derived method.

Methods
Fifty-eight LBBB patients without coronary artery disease (mean age 65 ± 13 years, 60% male) were divided into 4 groups based on their LVEF according to current recommendations for cardiac chamber quantification (figure A): normal (n= 25), mildly (n= 16), moderately (n= 11), and severely (n= 6) reduced LVEF. Septal and lateral wall MWI and MWE were estimated by LV pressure-strain loop obtained by echocardiography.

Results
Both MWI (787 mmHg%, 95% CI 651-924 vs 1956 mmHg%, 95% CI 1758-2154; p &lt; 0.0001) and MWE (71%, 95% CI 66-76 vs 85%, 95% CI 82-87; p = 0.0001) were lower in the septum than in the lateral wall. There was a progressive decrease in septal MWI and MWE with the worsening of LVEF (figure B). Conversely, MWI and MWE of the lateral wall were preserved in patients with normal, mildly and moderately reduced LVEF groups. A significant reduction of MWI and MWE in the lateral wall was detected only in patients with severely reduced LVEF (figure C).

Conclusion
In patients with LBBB, impairment in septal myocardial work escalates according to LVEF loss. Septal dysfunction was compensated by the effective myocardial work of the lateral wall in patients with normal, mildly and moderately reduced LVEF. Mechanical dysfunction of the lateral wall was associated with severe reduction of LVEF.
Abstract 102 Figure.
P172 Uncommon reason for right-sided heart failure
Authors: Mladenovic Z , Obradovic S O , Ilic I R , Djenic D J L J , Vranes V D , Djuric D J P , Jovic J Z 
Published: January 2020

Abstract
This paper outlines a case study 57 year old, female patient who was admitted in our institution due to severe sign and symptoms of right-sided heart failure. She complained on progressive fatigue, a shortness of breath and oedema of cruris for three months before. Initially she was hospitalized in regional hospital due to pericardial effusion and they excluded any malignancy and systemic tissue disease in that moment. Immediately after admission we have performed 2D transthoracic echocardiography which showed a large (6.7x4.9cm), oval tumours soft tissue formation in right atrium which compromise flow in Vena cava inferior and across tricuspid valve and make a gradient of 35 mmHg above it. Left and right ventricles had preserved dimensions and function, without pericardial effusion. 3D transoesophageal echocardiography (TEE) imaged confirmed huge, oval tumorous formation (8.2x7.9cm), which originated from lateral wall of right atrium and almost occupied it, compromising flow towards superior and inferior vena cava. We had detected an irregular free space, probably due to necrosis, in the middle part of that tumorous formation.
Thorax MSCT revealed heterogeneous expansive mass (19x8x8 cm) in projection of right atrium with signs of active bleeding its central part, although MSCT couldn’t exclude extra cardiac origin. There were no signs of dissemination. Cardiac MR indicated that we had extra cardiac mass (12x9x10cm) close to lateral right atrial wall and basal part of lateral wall of right ventricle which compromise flow towards superior and inferior vena cava, with no changes on surrounding structures.
The patient underwent almost complete tumour surgical resection, with a lot of bleeding complications due to its local invasiveness and central necrosis. Surgical findings completely were concordant with 3D TEE imagining which provided us very precise information about size, location and extension of tumour. Severe systemic inflammatory response syndrome (SIRS) occurred in the postoperative period, and the patient died due to multiple organ dysfunction. Patohistological analyses were conclusive of undifferentiated pleomorphic sarcoma diagnosis.
Abstract P172 Figure.
P199 Mitral valve annular disjunction prevalence and significance amongst patients with mitral valve prolapse
Authors: Faia Carvalho Dias G , Faria B , Von Hafe P , Cardoso A F , Azevedo O , Fernandes M , Leite S , Cordeiro F , Castro F , Lourenco M , Almeida F , Lourenco A 
Published: January 2020

Abstract

Background
Mitral valve prolapse (MVP) is a common and usually benign entity. Occasionally, patients with MVP present with mitral annular disjunction (MAD), whose prevalence and clinical significance are still not clearly established.

Purpose
This study aimed to define the prevalence of MAD in a population of patients with MVP and study its echocardiographic and clinical implication.

Methods
A total of 31 patients with MVP who underwent echocardiographic evaluation in our laboratory were retrospectively evaluated. Echocardiographic, demographic and clinical variables were assessed. Disjunction amplitude (DA) was measured in parasternal long axis view (PLAX) and MAD was considered present if a separation of ≥ 5mm was verified. Annular diameter was measured in PLAX and apical four chamber view (A4C) both in systole and diastole.

Results
MAD was identified in 9 patients (29%), having a mean DA of 12.3 ± 3.2 mm. The group of patients with MAD was significantly younger than the group without MAD (mean age of 54 ± 18 vs 67 ± 15 years; p = 0.001), but there were no significant differences regarding gender, height, weight or cardiovascular risk factors. DA was inversely correlated with body surface area (r=-0.8, p = 0.009). Systolic annular diameters in PLAX and A4C views were increased in patients with MAD (4.2 ± 0.6 vs 3.6 ± 0.7 mm, p= 0.04 and 4.8 ± 0.7 vs 4.1 ± 0.7 mm, p = 0.025, respectively). The difference between systolic and diastolic diameters in PLAX was also greater in MAD (0.5 ± 0.2 vs 0.1 ± 0.3 mm, p = 0.007). Posterior wall thickness (8.5 ± 1.1 vs 9.7 ± 1.4 mm, p = 0.035), indexed left ventricular mass (89.0 ± 15.8 vs 110.6 ± 40,2 g/m2, p = 0.04) and ascending aortic dimensions (28.7 ± 6.7 vs 37.4 ± 3.6 mm, p = 0.018) were notably inferior in MAD patients, as was left ventricle ejection fraction (LVEF) (57.5 ± 5.8 vs 62.6 ± 4.9 %, p = 0.0023). No differences were found in chamber volumes. Similarly, eletrocardiographic parameters were identical in both groups. Five patients (56%) in the group with MAD had documentation of events (palpitations, dizziness, syncope or sudden cardiac death), in contrast with just 3 (21%) in the group without MAD, although statistical significance was not achieved (p = 0.078).

Conclusion
This study revealed that MAD is common among patients with MVP and is associated with altered annulus dynamics during the cardiac cycle. Its association with younger individuals, lower LVEF and, apparently, more clinical events highlight the importance of this entity.
P216 Cardiac amyloidosis is not a single disease: an echocardiographic study of light chain vs transthyretin forms
Authors: Adam R D , Jercan A , Badelita S , Coriu D , Stan C , Serban M , Beladan C , Rosca M , Balahura A M , Ginghina C , Popescu B A , Jurcut R 
Published: January 2020

Abstract

Background
Cardiac amyloidosis (CA) is described as one entity. However, several subtypes of amyloid can infiltrate the heart: light chain (AL) and tranthyretin (ATTR) are the most common.

Purpose
To characterize the specific findings of the CA subtypes as a tool to aid differential diagnosis between AL and ATTR CA.
Material and methods: Consecutive patients with CA were evaluated by clinical examination, ECG, cardiac biomarkers and echocardiography with both conventional and myocardial deformation study of the left ventricle (LV), left atrium (LA) and right ventricle (RV). Amyloid subtype was described using light chain assessment for AL-CA and 99Tc-HMPD scintigraphy and TTR gene sequencing for ATTR-CA.

Results
32 patients with CA were included, 13 with ATTR and 19 with AL. Patients in AL group were significantly older, with higher levels of cardiac biomarkers. At similar LV EF and wall thickness, they had lower GLS. LA function parameters were also lower in AL pts (table). Using ROC curves, the best predictors for AL diagnosis were NTproBNP (AUC 0.937) and Tn levels (AUC 0.958), as well as LV GLS and pericardial fluid presence (both AUC 0.750).

Conclusions
At similar LV wall thickness and ejection fraction, cardiac dysfunction appears to be more severe in AL pts, with lower global LV longitudinal strain, worse LA function, higher sPAP and NTproBNP.
ATTR (13 pts) AL (19 pts) p Age (years) 50 ± 12 60 ± 8 0.01 NTproBNP (pg/mL) 3066 ± 3720 11755 ± 9114 0.02 hsTnI (ng/mL) 0.005 ± 0.008 0.147 ± 0.161 0.04 Pericardial fluid (%) 53% 100% 0.002 LVEDV (mL) 88 ± 25 75 ± 38 NS LVMi (g/m2) 166 ± 47 168 ± 41 NS LVEF (%) 50 ± 8 49 ± 16 NS LV GLS (%) -12.1 ± 3.8 -8.9 ± 4.5 0.04 Septal Basal/Apical LS 0.33 ± 0.17 0.25 ± 0.27 NS LAVi (mL/m2) 46 ± 21 45 ± 14 NS LAEF 4CV (%) 35 ± 21 24 ± 8 0.05 LA systolic strain (%) 17.4 ± 11.9 10.5 ± 5.0 0.02 RV free wall thickness (mm) 7.0 ± 1.5 7.6 ± 1.4 NS RV 6-segments strain (%) -15 ± 4 -10 ± 8 0.09 sPAP (mmHg) 36.6 ± 12.0 48.6 ± 17.2 0.04
P220 Behcet"s disease with right ventricular aneurysm
Authors: Stoodley P , Tanous D 
Published: January 2020

Abstract

Funding Acknowledgements
Nil

Introduction
Behcet’s disease (BD) is a rare inflammatory disorder, which predominantly impacts people of Mediterranean and East Asian origin. While the aetiology is unknown, the prevailing disorder is vasculitis. Oral, skin and ocular lesions are common: cardiac involvement is rare.
Case description
A sixty-three year old male with Behcet’s disease (BD) presented for review. On clinical examination, atrial fibrillation, prominent V waves, mild pedal oedema and a ‘to and fro’ murmur were noted. Marked elevation of right ventricular (RV) end diastolic pressure was measured by cardiac catheter.
Echocardiography and magnetic resonance imaging revealed significant RV abnormalities. The mid and apical RV regions were heavily trabeculated, and an anterior aneurysm was identified (see 2D image in abstract picture). A prominent horizontal muscular ridge in the basal RV was noted, and the RV outflow tract was narrowed. While the tricuspid valve was not apically displaced, leaflet coaptation was absent with subsequent severe tricuspid regurgitation into a grossly enlarged right atrium (see colour image in abstract picture). Management included diuretics and continuing immunosuppressives.

Discussion
BD is a rare (chronic) inflammatory disorder, which mainly affects people of Mediterranean and East Asian origin, and is often first diagnosed (in the third or fourth decades of life) following recurrent oral ulcerations, skin and ocular lesions. With BD, the prevailing disorder is vasculitis. Blood vessels of all sizes, both arteries and veins, are impacted: true or false aneurysms can occur.
BD rarely affects the heart. If there is cardiac involvement, pericarditis is the most common lesion - others include myocarditis, mitral valve prolapse, intra-cardiac thrombus and myocardial infarction. We present a rare (and possibly unique) cardiac manifestation of BD, anterior RV aneurysm.

Conclusion
In this case report we present a rare cardiac manifestation of BD, anterior RV aneurysm.
Abstract P220 Figure. Echocardiography Images
P221 Carcinoid heart disease
Authors: Tyminska A , Kaczmarska-Turek D , Kaplon-Cieslicka A , Kochanowski J , Scislo P , Bednarczuk T , Opolski G 
Published: January 2020

Abstract
Carcinoid heart disease is a rare disease, which develops in 20-50% of patients with carcinoid syndrome and is a main predictor of clinical outcome in those patients. Typical cardiac involvement of this disease presents as primary diseases of the tricuspid or pulmonary valves with a rare affection of left sided heart valves. The characteristic pathological findings are endocardial plaques of fibrous which may involve not only the valve leaflets, but also the subvalvar apparatus.Typical management of patients with this condition consist of the treatment of right heart failure (HF), pharmacotherapy to reduce the secretion of tumour products, and surgical valve replacement. Here we report a 56-year old male admitted to the Department of Endocrinology because of flushing with abdominal pain and diarrhea 2-3 times a week for 2 years. During hospitalization carcinoid syndrome with metastases to the liver and abdominal lymph nodes was diagnosed. Treatment with a long-acting somatostatin analog was initiated, resulting in a good control of the symptoms of the carcinoid syndrome. Trans-thoracic echocardiography revealed right atrial and right ventricular enlargement with degenerative lesions of tricuspid valve leaflets and its subvalvular apparatus, with leaflet stiffening, retraction and malcoaptation, resulting in severe tricuspid regurgitation (vena contracta [VC] width - 7 mm). Pulmonic valve was also involved with thickening of pulmonary valve cusps leading to mild pulmonary stenosis (peak gradient [PG] - 27 mmHg, mean gradient [MG] - 14 mmHg) and mild pulmonary regurgitation. Moreover, signs of pulmonary hypertension (with tricuspid regurgitation pressure gradient [TRPG] of 50 mmHg and estimated systolic pulmonary artery pressure [SPAP] of 50-55 mmHg) was observed. There were no signs of hemodynamically significant left-sided valve disease, nor of any abnormalities in segmental or global left ventricular function. After 12 months of treatment with a long-acting somatostatin analog, the patient was reassessed. Despite a good control of carcinoid syndrome symptoms and reduction in carcinoid syndrome marker (5-hydroxyindoloacetic acid), exacerbates the tricuspid regurgitation and worsens right HF was observed. Control echocardiographic examination showed significant progression of the pulmonary valve disease with severe pulmonary regurgitation (VC width - 10 mm) and mild pulmonary stenosis (PG 18 mmHg, MG 8 mmHg), a deterioration of tricuspid regurgitation (VC width - 11 mm, effective regurgitant orifice area - 0.94 cm2, regurgitant volume - 64 ml) with further enlargement of the right ventricle and right atrium, and with a consequent decrease in TRPG value (25 mmHg), despite well preserved right ventricular systolic function (TAPSE - 24 mm). Due to disease progression, treatment of HF and peptide receptor radionuclide therapy were initiated. The patient was presented for surgical valve replacement, however he did not agree to surgical treatment.
Abstract P221 Figure
P222 Pycnodysostosis and cardiac congenital defects: a rare association
Authors: Almeida I , Miranda H , Santos H , Santos M , Chin J , Almeida S , Tavares J 
Published: January 2020

Abstract

Introduction
Pycnodysostosis is a rare recessive autosomal hereditary disease associated with skeletal dysplasia, with no evidence of associated cardiac defects.

Clinical case
The authors report a case of a 29-years old male patient with previous diagnosis of pycnodysostosis and a corrected subaortic ventricular septal defect. He was admitted at the emergency room due to productive cough with purulent expectoration which started one week before, refractory to the first antimicrobial therapy. The patient evolved with respiratory failure and necessity of orotracheal intubation and invasive mechanical ventilation. Large spectrum antimicrobial therapy was initiated after blood cultures and serologies for atypical agents of pneumonia collection (all negative). Due to the persistence of fever and elevation of inflammatory parameters, a transthoracic echocardiogram was performed to evaluate the presence of vegetations or other complications of infective endocarditis, not excluding this hypothesis. A transesophageal echocardiogram (TEE) was then performed showing a severe dysplastic mitral valve with flail of both leaflets conditioning a torrential mitral regurgitation occupying all the left atrium; and a tricuspid valve also dysplastic with no significant regurgitation. The patient was proposed to cardiac surgery. Intraoperative TEE revealed mitral dysplastic leaflets both inserted in a single papillary muscle constituting a congenital abnormally designated parachute mitral valve presenting with torrential mitral regurgitation and no images suggestive of vegetations neither other complications. A mechanical prothesis was successfully implanted in mitral position with subsequent favorable clinical evolution.

Conclusion
In this case, the authors report two concomitant rare congenital abnormalities: one in the mitral valve and the other affecting the skeletal system, which are usually not associated.
Abstract P222 Figure.