bluuebunny/crossref_metadata_2025_split huggingface dataset:
Notes on the Use of the Sign URBS (L.225) in Anatolian Hieroglyphic
Authors: Trameri Andrea 
Published: November 2019

Abstract
This article discusses the use of the sign <URBS> (L.225) in Anatolian Hieroglyphic. In particular, it analyzes the attestations and contexts of use of the sign employed in combination with <mi> (L.391) (§ 2). It is well-known that the self-standing sign <URBS> was used as a determinative for city names, while the form with ligature +MI was employed as a logogram. A systematic analysis of the Anatolian Hieroglyphic corpus shows that this convention was very consistent. This article provides an updated corpus of attestations of the logographic usage; it is also shown that a less common form of this sign combination, without ligature (<URBS-MI>), was an alternative logographic writing in the early stage of the script, but the form with ligature (<URBS+MI>) became the standard after the 12th century. Possible exceptions to this convention and other inconsistent or problematic uses are discussed (§ 3). Conclusions include some considerations on the possible phonetic quality of the ligature +MI, and on the form of the Luwian word for “city” (§ 4). The final section discusses the use of the sign <URBS> in the spelling of the name Mursili, in light of the present analysis (§ 5).
An investigation of the effects of level density models and alpha optical model potentials on the cross-section calculations for the production of the radionuclides 62Cu, 67Ga, 86Y and 89Zr via some alpha induced reactions
Authors: Şekerci Mert 
Published: November 2019

Abstract
Theoretical studies via nuclear reaction models have an undeniable importance and impact in terms of better understanding of reaction processes and their nature. In this study, by considering the importance of these models and the medical radionuclides, the effects of six level density models and eight alpha optical model potentials on the cross-section calculations for the production of the radionuclides 62Cu, 67Ga, 86Y and 89Zr via 59Co(α,n)62Cu, 60Ni(α,np)62Cu, 65Cu(α,2n)67Ga, 64Zn(α,p)67Ga, 85Rb(α,3n)86Y, 86Sr(α,n)89Zr, 87Sr(α,2n)89Zr and 88Sr(α,3n)89Zr reactions were investigated. Calculations for each reaction route were performed by using the TALYS v1.9 code. The most consistent model with the literature data taken from the Experimental Nuclear Reaction Database (EXFOR), was identified by using the reduced chi-squared statistics in addition to an eyeball estimation. Also, the effects of combinational use of selected models and potentials were investigated by comparing the calculational results with the experimental data.
Effectiveness and toxicity of lenvatinib in refractory thyroid cancer: Dutch real-life data
Authors: Aydemirli M D , Kapiteijn E , Ferrier K R M , Ottevanger P B , Links T P , van der Horst-Schrivers A N A , Broekman K E , Groenwold R H H , Zwaveling J 
Published: November 2019

Objective
The SELECT trial showed progression-free survival (PFS) benefit for lenvatinib for advanced radioiodine-refractory differentiated thyroid cancer (RAI-refractory or RR-DTC) patients, on which current clinical practice is based. We assessed whether the effectiveness and toxicity of lenvatinib in real-life clinical practice in the Netherlands were comparable to the pivotal SELECT trial.

Methods
From three Dutch centres Electronic Health Records (EHRs) of patients treated in the lenvatinib compassionate use program or as standard of care were reviewed and checked for SELECT eligibility criteria. Baseline characteristics, safety, and efficacy measures were compared and PFS and overall survival (OS) were calculated. Furthermore, PFS was compared to estimates of PFS reported in other studies.

Results
A total of 39 DTC patients with a median age of 62 years were analysed. Of these, 27 patients (69%) did not fulfil the SELECT eligibility criteria. The most common grade ≥3 toxicities were hypertension (n = 11, 28%), diarrhoea (n = 7, 18%), vomiting (n = 4, 10%), and gallbladder disease (n = 3, 8%). Median PFS and median OS were 9.7 (95% confidence interval (CI): 4.0–15.5) and 18.3 (95% CI: 4.9–31.7) months, respectively, response rate was 38% (95% CI: 23–54%). PFS in the Dutch real-life situation was comparable to previous real-life studies, but inferior to PFS as shown in the SELECT trial (P = 0.04).

Conclusions
PFS in our non-trial population was significantly shorter than in the SELECT trial population. In the interpretation of results, differences in the real-life population and the SELECT study population regarding patient characteristics should be taken into account.
Transcription Profiles of Age-at-Maturity-Associated Genes Suggest Cell Fate Commitment Regulation as a Key Factor in the Atlantic Salmon Maturation Process
Authors: Kurko Johanna , Debes Paul V , House Andrew H , Aykanat Tutku , Erkinaro Jaakko , Primmer Craig R 
Published: November 2019

AbstractDespite recent taxonomic diversification in studies linking genotype with phenotype, follow-up studies aimed at understanding the molecular processes of such genotype-phenotype associations remain rare. The age at which an individual reaches sexual maturity is an important fitness trait in many wild species. However, the molecular mechanisms regulating maturation timing processes remain obscure. A recent genome-wide association study in Atlantic salmon (Salmo salar) identified large-effect age-at-maturity-associated chromosomal regions including genes vgll3, akap11 and six6, which have roles in adipogenesis, spermatogenesis and the hypothalamic-pituitary-gonadal (HPG) axis, respectively. Here, we determine expression patterns of these genes during salmon development and their potential molecular partners and pathways. Using Nanostring transcription profiling technology, we show development- and tissue-specific mRNA expression patterns for vgll3, akap11 and six6. Correlated expression levels of vgll3 and akap11, which have adjacent chromosomal location, suggests they may have shared regulation. Further, vgll3 correlating with arhgap6 and yap1, and akap11 with lats1 and yap1 suggests that Vgll3 and Akap11 take part in actin cytoskeleton regulation. Tissue-specific expression results indicate that vgll3 and akap11 paralogs have sex-dependent expression patterns in gonads. Moreover, six6 correlating with slc38a6 and rtn1, and Hippo signaling genes suggests that Six6 could have a broader role in the HPG neuroendrocrine and cell fate commitment regulation, respectively. We conclude that Vgll3, Akap11 and Six6 may influence Atlantic salmon maturation timing via affecting adipogenesis and gametogenesis by regulating cell fate commitment and the HPG axis. These results may help to unravel general molecular mechanisms behind maturation.
Control of Locomotory Behavior of Caenorhabditis elegans by the Immunoglobulin Superfamily Protein RIG-3
Authors: Bhardwaj Ashwani , Pandey Pratima , Babu Kavita 
Published: November 2019

Abstract
Cell surface immunoglobulin superfamily (IgSF) proteins play important roles in the development and function of the nervous system . Here we define the role of a Caenorhabditis elegans IgSF protein, RIG-3, in the function of the AVA command interneuron. This study reveals that RIG-3 regulates the abundance of the glutamate receptor subunit, GLR-1, in the AVA command interneuron and also regulates reversal behavior in C. elegans. The mutant strain lacking rig-3 (rig-3 (ok2156)) shows increased reversal frequency during local search behaviors. Genetic and behavioral experiments suggest that RIG-3 functions through GLR-1 to regulate reversal behavior. We also show that the increased reversal frequency seen in rig-3 mutants is dependent on the increase in GLR-1 abundance at synaptic inputs to AVA, suggesting that RIG-3 alters the synaptic strength of incoming synapses through GLR-1. Consistent with the imaging experiments, altered synaptic strength was also reflected in increased calcium transients in rig-3 mutants when compared to wild-type control animals. Our results further suggest that animals lacking rig-3 show increased AVA activity, allowing the release of FLP-18 neuropeptide from AVA, which is an activity-dependent signaling molecule. Finally, we show that FLP-18 functions through the neuropeptide receptor, NPR-5, to modulate reversal behavior in C. elegans.
Efeitos dos Exercícios Físicos em Pacientes Submetidos à Quimioterapia Paliativa
Authors: Greco Fernanda Palmas , Pinto Larissa Vieira , Lucatto Jeanette Jaber , Cunha Thiago Maracinni , Silva Janete Maria , Alveno Daniel Antunes 
Published: November 2019

Introdução: O envelhecimento no Brasil avança a passos largos com aumento da prevalência de doenças crônicas não transmissíveis (DCNTs), sendo estas as principais causas de óbito no mundo. As neoplasias são a segunda DCNT mais prevalente e demandam muitos recursos em saúde. A quimioterapia paliativa é um dos tratamentos de escolha para controle de sintomas da neoplasia, pode promover desde fadiga à neuropatia periférica. Por este motivo, os exercícios físicos têm sido recomendados em pacientes com esse tipo de tratamento. Objetivo: Verificar os efeitos dos exercícios físicos em pacientes submetidos a quimioterapia paliativa. Método: Revisão sistemática, seguindo as orientações PRISMA. Pesquisa realizada nas bases de dados eletrônicas LILACS, MEDLINE, PEDro, Clinical Trial e SciELO, consultado pelos descritores: terapia medicamentosa (drug therapy), índice de gravidade da doença (severity of illness index), reabilitação (rehabilitation), exercício físico (physical exercise) e cuidados paliativos (palliative care). Incluídos artigos em português e inglês, sem delimitação de data, ensaios clínicos. A avaliação da qualidade metodológica seguiu a escala de risco de viés da Cochrane. Resultados: Selecionados 10 artigos, sendo cinco com baixo risco de viés; três com viés incerto; e dois com alto risco. Todos os estudos observaram melhora significativa no grupo intervenção quando comparado ao grupo controle nos seguintes desfechos: qualidade vida, controle de sintomas e autonomia. Quanto ao tipo de exercício, apenas cinco compararam diferentes modalidades de exercícios (aeróbios, resistidos ou mistos) e não encontraram diferença estatística entre eles. Outros quatro artigos utilizaram um tipo de exercício, e apenas um estudo utilizou eletroestimulação, não promovendo avanço no nível de atividade física, força muscular e controle de sintomas (dor e fadiga). Conclusão: Embora poucos estudos na literatura, os exercícios físicos parecem contribuir para melhora da força muscular, qualidade de vida, controle de sintomas e manutenção da funcionalidade em pacientes submetidos a quimioterapia paliativa.
Descritores: Tratamento Farmacológico; Reabilitação; Índice de Gravidade de Doença; Cuidados Paliativos.
Neuroedukacja a niespecyficzne problemy w nauce dzieci i dorosłych
Authors: Imperowicz-Jurczak Małgorzata , Jurczak Robert 
Published: November 2019

Neuroedukacja wykorzystuje techniki treningu na poziomie neuronalnym w celu skutecznej stymulacji mózgu w procesie uczenia się zarówno dzieci, jak i dorosłych, osób zdrowych i z niepełnosprawnościami. W artykule zaprezentowano własne wyniki i wnioski dwu cykli treningowych (8-letnie dziecko i 56-letni dorosły) z wykorzystaniem metod: neurofeedbacku, audioterapii, kynoterapii oraz ćwiczeń integracji międzypółkulowej. Metody te okazały się atrakcyjne dla trenujących w każdym wieku, nie wymagały od terapeuty odwoływania się do doświadczeń człowieka, zmiany jego przekonań. Efekty neurotreningu miały na celu wspieranie pracy mózgu, poprawę uwagi słuchowej, wyników uczenia się, pamięci oraz radzenie sobie w sytuacjach stresogennych.
Problematyka przestępczości i więziennictwo w pracach dyplomowych studentów Wyższej Szkoły Bezpieczeństwa i Ochrony im. Marszałka Józefa Piłsudskiego w Warszawie w latach 2007-2017
Authors: Pomiankiewicz Jacek 
Published: November 2019

Celem autora jest ukazanie skali zainteresowania studentów problematyką przestępczości oraz zagadnieniami więziennictwa przy przygotowywaniu prac dyplomowych licencjackich i magisterskich w Wyższej Szkole Bezpieczeństwa i Ochrony im. Marszałka Józefa Piłsudskiego w Warszawie od początków jej funkcjonowania (2005) do ubiegłego roku (2018). Artykuł powstał na podstawie dokumentacji wewnętrznej uczelni, przechowywanej w dziekanatach oraz w archiwum. Zakres problemowy prac dotyczących przestępczości i systemu penitencjarnego był bardzo zróżnicowany. Jest on odbiciem głównych zjawisk w wymiarze historycznym i współczesnym. Autor podaje i omawia przykłady tematów.
Relacja resocjalizacyjna i jej znaczenie w narracji wychowawców zakładu karnego
Authors: Sobczyszyn Urszula , Jeziorański Marek 
Published: November 2019

Celem artykułu jest zaprezentowanie stanowiska wychowawców Służby Więziennej na temat znaczenia relacji z osadzonymi dla optymalizacji prowadzonych działań naprawczych. Artykuł składa się z dwóch głównych części. W pierwszej przedstawione zostały założenia teoretyczne dotyczące kategorii „relacji wychowawczej” H. Nohla, które następnie zostały odniesione do specyfiki środowiska resocjalizacyjnego. Wynikiem tego działania jest przedstawienie teoretycznych podstaw „relacji resocjalizacyjnej” oraz jej zoperacjonalizowanych obszarów. W drugiej części artykułu zostały zaprezentowane wyniki przeprowadzonych badań oraz wnioski i postulaty pedagogiczne.
Wolontariat w procesie resocjalizacji w Zakładach Karnych
Authors: Braun Katarzyna 
Published: November 2019

Artykuł dotyczy możliwości wykorzystania wolontariatu jako narzędzia zmiany postaw osadzonych. Składa się z czterech części. W pierwszej zostały omówione podstawowe informacje dotyczące wolontariatu w Polsce, jego założenia oraz unormowania prawne, w drugiej – założenia działalności resocjalizacyjnej w środowisku zamkniętym. Części trzecia i czwarta prezentują doświadczenia związane z realizacją programów wolontarystycznych w Zakładach Karnych w Polsce. Trzecia omawia wybrane programy zaangażowania wolontariuszy w zakładach karnych, natomiast czwarta jest analizą działalności osadzonych jako wolontariuszy.
A Large-Scale Detection, Identification and Quantification of Target Metabolites using dMRM-MS Combined with Transcriptome of Two Rheum Species Focused on Anthraquinone and Flavonids Biosynthesis
Authors: chen sha , Liu Jing , Leng Liang , Gao Han , Yang Wei , Liu An 
Published: November 2019

Abstract
Background

Rheum emodi ( R. emodi ) is a perennial herb as well as an important medicinal plant. The main active compounds in Rhubarb are anthraquinones, but also contains flavonoids. As a class of important active components in rhubarb, anthraquinones have many pharmacological effects. However, due to the lack of rhubarb genome, it is difficult to mine functional genes involved in the biosynthesis of anthraquinones in rhubarb.

Results

Based on the a large-scale quantification of target metabolites combined with the transcriptome data of Rheum Palmatum L . (RPL) and Rheum Officinale Bails (ROB), in this study we aimed to firstly mine out anthrquinones and other pharmacological metabolites in rhubarb, then search genes which may related to the biosynthesis of anthraquinones and other metabolites. Via dynamic-multiple reaction monitoring (dMRM) of triple quadrupole mass spectrometry (QqQ-MS) technical means, 62 compounds including 21 anthraquinones, 17 flavonoids, 6 stilbenes, 12 gallate esters, 3 tannins, and 3 others were simultaneous qualitatively and quantitatively assessed. Furthermore, a total of 180,689 transcripts and 90,242 unigenes were generated by the de novo transcriptome assembly. Down-stream bioinformatic analyses annotated the unigenes with BLAST against seven public databases including KEGG and KOG. GO and KEGG pathway analyses further characterized the unigenes, resulting in 21,691 unigenes with metabolic pathway annotations. There were 121 genes annotated in the flavonoid pathways, and 38 of them showed a significant difference in expression level between the RPL and ROB. According to the difference in the content of emodin and physcion in the two kinds of rhubarb and the expression level of key enzyme genes, we further search 7 differentially expressed genes annotated with the activity of caffeoyl coenzyme methyltransferase. RT-qPCR results showed that the expression of the cluster-14354.38156 in the ROB was approximately 14-fold higher than that observed in the RPL, which may participate in the process of O-methylation from emodin to physcion.

Conclusion

Combining metabolome and transcriptome analysis, a key enzyme gene was identified. This study supplied a useful resource for further study of metabolite in rhubarb.
Advanced Planning and Scheduling Based on the Constraint Theory and Improved Tabu Search Algorithm
Authors: Zheng Jianguo , Mi Xiaomei , Liao Huchang 
Published: November 2019

Background:
Planning and scheduling of manufacturing enterprises are required to be
rapid and accurate, which make is easy for the traditional enterprise resource planning system to
meet the needs of enterprises.

Objective:
This paper introduces the theory of constraints and explains the control methods for production
planning and scheduling.

Methods:
The main characteristics of the advanced planning and scheduling system are analyzed.
Then, the modeling method based on the theory of constraints is used to study the scheduling path.

Results:
An example is given to validate the scheduling model and realize the optimization of production
tasks on the bottleneck resources.

Conclusion:
The feasibility of the advanced planning and scheduling methods based on the theory of constraints is proved.
Wholegrain Particle Size Influences Postprandial Glycemia in Type 2 Diabetes: A Randomized Crossover Study Comparing Four Wholegrain Breads
Authors: Reynolds Andrew N. , Mann Jim , Elbalshy Mona , Mete Evelyn , Robinson Caleb , Oey Indrawati , Silcock Pat , Downes Nerida , Perry Tracy , Te Morenga Lisa 
Published: November 2019

OBJECTIVE
Wholegrain foods vary in the extent of processing. We investigated whether wholegrain particle size in bread influences postprandial glycemia in type 2 diabetes.

RESEARCH DESIGN AND METHODS
Postprandial glycemia (incremental area under the blood glucose curve [iAUC]) was measured after consumption of three breads made with roller-milled wholegrain flour and added grains and a fourth made with stone-ground flour. All flours and grains were 100% wholegrain wheat. Breads were nutrient matched.

RESULTS
Fifteen adults (64 ± 10 years, HbA1c 58 ± 13 mmol/mol) completed the study. iAUC for the three breads made with roller-milled flour ranged from 376 to 641 mmol−1min−1, inverse linear trend for grain particle size P = 0.039. The iAUC for stone-ground wholegrain bread (503) was smaller than predicted from mean particle size.

CONCLUSIONS
Wholegrain structural integrity in bread is a determinant of glycemic response. These findings have implications for dietary advice and the definition of the term “‘wholegrain.”
Progress in Renewable Energy Technologies: Innovation Potential in Latvia
Authors: Suharevska Karina , Blumberga Dagnija 
Published: November 2019

Abstract
The development of renewable energy technologies (RET) depends on a wide range of criteria and regulations. To evaluate which RET (solar photovoltaic (PV), wind power plants (WPP), hydroelectric power plants (HPP) or bio-energy plants) have the greatest potential in Latvia, the most suitable approach is a multiple criteria decision making (MCDM). The proposed MCDM methodology involves TOPSIS model based on information entropy, which contributes as a criteria weighting tool. The study investigates seven main criteria from technical, economic, environmental and social aspects. Firstly, each alternative country is analysed due to the chosen RET criteria. Secondly, the assessment is extended, comparing specific data with Latvia’s MCDM of RET results. The research results show that, according to the best available examples of RET, hydro energy plants still play a substantial role for Latvia, the most promising RET development is based on bio-energy and wind renewable energies.
Optimization of the Effective Heat Supply Radius for the District Heating Systems
Authors: Stennikov Valery , Mednikova Ekaterina , Postnikov Ivan , Penkovskii Andrey 
Published: November 2019

Abstract
The problem of determining the effective (optimal) heat supply radius is considered. Heat supply radius is transportation distance of heat energy in the district heating systems (DHS), under which the highest indices of economic efficiency of district heating to consumers are respected. To solve this difficult and multifactorial problem, a bi-level approach has been proposed. This approach allows finding the optimal frameworks of territorial areas of district heating while fulfilling the necessary requirements for thermal-hydraulic modes in heat networks and for reliability of heating to consumers. Methodology for solving the formulated problem is based on bi-level programming methods, models of Theory of hydraulic circuits, nonlinear optimization methods, nodal reliability indices (availability factor, failure-free operation probability), Markov random processes models and other methods and models. A case study has been conducted using the developed methodological apparatus for the actual DHS scheme of the Irkutsk city (Russia, Siberia).
Single Cell Oil Production from Waste Biomass: Review of Applicable Industrial By-Products
Authors: Spalvins Kriss , Vamza Ilze , Blumberga Dagnija 
Published: November 2019

Abstract
Single cell oil (SCO) is an attractive alternative source of oil, which, depending on the fatty acid composition, can be used as a feedstock for biodiesel production, as an ingredient for pharmaceuticals or as a source of essential fatty acids for human and animal consumption. However, the use of SCO is limited due to use of relatively expensive food or feed products in the cultivation of SCO producing microorganisms. In order to reduce SCO production costs, the use of cheaper feedstock such as biodegradable agro-industrial wastes are necessary. At the same time, the microbial treatment of biodegradable wastes ensures the neutralization of environmentally harmful compounds and reduces the negative impact on the environment. Oleaginous microorganisms are capable of fermenting a variety of industrial by-products, waste products and wastewaters, however further discussion on properties of the waste materials is necessary to facilitate the selection of the most appropriate waste materials for SCO production. Thus, this review compares various industrial waste products that can be used as cheap feedstock for the cultivation of SCO producing microorganisms. Industrial waste products, by-products and wastewaters are compared according to their global availability, current use in competing industries, required pre-fermentation treatments, oleaginous microorganism cell concentrations and SCO yields.
New PV Micro-Modules on Standard Roof Tiles
Authors: Wujek Pawel , Sprawka Piotr 
Published: November 2019

Abstract
Various technologies available on the solar photovoltaic cell market have been reviewed. The method of photovoltaic micro-modules implementation on standard roof tiles was shown. The possible roof tiles were chosen. Problems related to micro PV modules design and concept of final product developed at Electrotile Company have been described. It was shown that solar panel modules consisting of 6 two-cell setups on the Tysenia roofing tile generated power of 38.5 W or 42 W, depending on cell type.
La televisión regional: una oportunidad para la facultad de educación
Authors: Avendaño Alvaro 
Published: November 2019

1. La comunicación
La realidad hoy está mediada por la televisión y los medios de comunicación. Para nuestros niños es más cotidiano y familiar zonas con el Urabá, ciudades como Washingtong, que el fértil valle de nuestro vecino Palermo o el municipio de Paicol: La información produce un debilitamiento de lo real a medida que a través de ella se realiza el contacto con el mundo real.