bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anger Mediates the Relationship between Pain and Depression in Irritable Bowel Syndrome
Authors: Fadgyas Stanculete Mihaela , Capatina Octavia , Pojoga Cristina , Surdea Blaga Teodora 
Published: December 2019

Background and Aims: Anger has been linked to irritable bowel syndrome (IBS), but the mechanism underlying this relationship is still unknown. This cross-sectional study explores the possibility that anger mediates the relationship between pain severity and depression in IBS patients.
Methods: The sample included 70 consecutively evaluated patients who met Rome III criteria for IBS diagnosis and 55 healthy controls. All participants completed measures of depression, pain, state and trait anger, and anger expression style.
Results: Using a mediational model involving a series of linear regressions we found that trait anger and anger expression index partially mediated the association between depression and abdominal pain severity. The IBS patients with significant pain reported higher depressive symptoms; these results could be partially explained by their tendency to experience angry feelings generated by pain.
Conclusions: The relation between pain and depression is not a direct and linear one, but works partly through patients’ tendency to become angry and through anger expression style regarding their pain.
Jankovichian, Szeletian or a leaf point industry: Analysis of three small lithic assamblages
Authors: Markó András 
Published: December 2019

Abstract
The eponymous site of the Jankovichian industry was found at the Öreg kő cliff, in the northern part of the Transdanubia, Western Hungary. From the thick layer complex of the Jankovich cave, however, only 104 lithics were collected and the scarce data showed that the pieces belong to several archaeological entities. At the same time, the nearly total lack of the field documentation allowed the reconstruction of the stratigraphic position of each artefact only in a few cases. The stratigraphic integrity is missing from the archaeological material of the Kiskevély and Szelim caves as well as the Csákvár rock shelter, and according to the recent evaluations the bifacial tools from the Dzeravá skála (Pálffy cave) and Lovas belong to the Micoquian and the Late Palaeolithic period.
In this paper we analyse the following three assemblages, excavated after World War II in Transdanubia: the Pilisszántó rock shelter II, the Bivak and the Remete Felső caves. The chronological, basically, bio-stratigraphic data known from these layers are also evaluated.
The conclusion of the study is that (1) the chronological data of the studied sites do not permit to place the archaeological occupation of each cave into the Early Würm or to the Late Middle Palaeolithic period and (2) the validity of a distinct Jankovichian industry cannot be proved.
Cadastral field works on prehistoric mounds in the central part of the Tiszántúl region
Authors: Bede Ádám 
Published: December 2019

Abstract
The aim of the present paper is to provide a comprehensive report on the cadastral works of mounds in the central part of Tiszántúl (the region east of the Tisza River), taking the burial mounds of the Late Copper Age Yamnaya entity as a starting point. Theoretical and field research began around the beginning of the 19th century, and in the second half of the 20th century systematic site registration took place, mainly due to the so-called ‘Archaeological Sites of Hungary’ project. Later on national surveys and local initiatives were carried out, but they are of very different quality. In addition to the main characteristics and results of the creation of these cadastres, we also outline further scientific studies on mounds.
El componente social de la amenaza híbrida y su detección con modelos bayesianos
Authors: Ruiz-Ruano Ana-María , López-Puga Jorge , Delgado-Morán Juan-Jose 
Published: December 2019

Las sociedades contemporáneas están cada vez más condicionadas por el desarrollo de la tecnología informática. Esa tendencia deja entrever un panorama en el que cada ser humano se identifica por el binomio persona-computadora, mientras que la mayor informatización de la vida civil está generando ingentes cantidades de datos que son susceptibles de ser gestionados con fines bélicos. El objetivo de este artículo es abordar la utilidad potencial de las redes bayesianas como herramientas destinadas a la monitorización y detección temprana de ataques híbridos de carácter social a escala global. Como conclusión, planteamos que el uso de la inferencia y las redes bayesianas es útil para monitorear, detectar y supervisar el componente social de las amenazas híbridas a escala global por medio del análisis de las redes sociales.
Abstract
Contemporary societies are increasingly conditioned by the development of computer technology. This trend suggests a picture in which each human being is identified by the person-computer binomial while greater computerization of civil life is generating huge amounts of data that are likely to be managed for war purposes. The objective of this article is to address the potential utility of Bayesian networks aimed at monitoring and early detection of hybrid attacks of a global nature. We conclude that the use of inference and Bayesian networks is useful for monitoring, detection and supervision of the social component of hybrid threats globally through social network analysis.
Effectiveness of Leaves Extract Fractions of Archidendron jiringa (Jack) I.C Nielsen Against Microbes
Authors: Komala Oom , Wardatun Sri , Sari Lia Puspita 
Published: December 2019

Archidendron jiringa(Jack) I.C Nielsen) contains a lot of essential oils, saponins, alkaloids, terpenoids, steroids, tannins, glycosides, and flavonoids. Flavonoid is a secondary metabolite compound in a plant as antimicrobial. This study aims to determine the antimicrobial activity of fractions of ethanol 96%, n-hexan, ethyl acetate, and ethanol-water leaves extractand determine levels of favonoids. A. jiringaleaves extract were tested against Streptococus mutans, Pseudomonas aeruginosa, and Candida albicans. The research using agar disc diffusion technique for antimicrobial activity and colorimetric method to know the total of flavonoid. Chloramphenicol and ketoconazole were used as a reference standard. The result of this study shows fractions of ethanol 96%, n-hexane, ethyl acetate, and ethanol-water A. jiringaleaves extract can inhibit microbial growth of S. mutans, P. aeruginosa, and C. albicans.Total of flavonoids on the extract respectively are 1.13%, 0.494%, 2.337%, and 0.549%. determined with complementary colorimetry to each leaf extract fractionA. jiringawith aluminum chloride method. Absorption spectrum measurement using a spectrophotometer. The higher percent of flavonoids would cause greater bacteriainhibitory zone but only 0.090 for pearson correlation value. Conclusions ethyl acetate leaves extract most effective inhibit microbial growth from the other fractions.
ANALISIS PSIKOLOGI SASTRA DAN NILAI PENDIDIKAN KARAKTER NOVEL LAUT BERCERITA KARYA LEILA S. CHUDORI SERTA RELEVANSINYA SEBAGAI BAHAN AJAR APRESIASI SASTRA DI SMA
Authors: Setiawan Andy Rachmat , Saddhono Kundharu , Suhita Raheni 
Published: December 2019

<em>This research used qualitative research approach with psychology literature review. The data of this research came from the text in the novel Laut Bercerita while the data source came from the results of interviews with teachers, students, counseling and guidance’s teachers, and the authors. The data collection techniques using document analysis and interviews. The technique of taking research subjects with purposive sampling. Data validity using theory triangulation and data triangulation. Data analysis techniques using interactive analysis models which include data collection, data reduction activities, display data, and drawing conclusion. The research procedure consists of the preparation stage, the data collection stage, the data selection stage, the stage of conducting data analysis (interactive models), the stage of preparing the research report. The results of this research are 1) the novel Laut Bercerita has the completeness of intrinsic elements consisting of 7 elements, 2) the inner conflict in the main character can be understood through Sigmund Freud's theory (Id, Ego, Superego) that is able to be influenced by factors within the character itself or external factors of the people around him, 3) there are 12 values of character education contained in the novel Laut Bercerita, and 4) the novel Laut Bercerita is relevant when used as a teaching material for literary appreciation in SMA Negeri 5 Surakarta and SMA Muhammadiyah 1 Surakarta because it contains a lot of positive values that can be realized for students in real life.</em>
Asbestiform Minerals of the Franciscan Assemblage in California with a Focus on the Calaveras Dam Replacement Project
Authors: Bailey R. Mark 
Published: December 2019

ABSTRACT
The San Francisco Bay Area is underlain by bedrock of the Franciscan Assemblage, which outcrops in numerous places. A significant portion of these outcrops consists of rock types that contain both regulated and unregulated asbestiform minerals, including ultra-mafic serpentinites, various greenstones, amphibolites, blueschist, and other schists (talc-tremolite, actinolite, etc.). These rocks are a legacy of tectonic activity that occurred on the west coast margin of the North American plate ∼65–150 MY ago during subduction of the East Pacific and Farallon plates. The Calaveras Dam Replacement Project (CDRP), located in Fremont, California, is an example of an area within the Franciscan Assemblage that is substantially underlain by metamorphosed oceanic sedimentary, mafic, and ultra-mafic rocks in a tectonic subduction zone mélange with highly disrupted relationships between adjoining rock bodies with different pressure/temperature metamorphic histories. In order to protect the health of workers and residents in the surrounding area, an extensive effort was taken to identify, categorize, and monitor the types, locations, and concentrations of naturally occurring asbestos at the site. Using a combination of geologic field observations and transmission electron microscopy, energy dispersive X-ray, and selected area electron diffraction analysis of airborne particulate and rock/soil samples, the CDRP was discovered to contain chrysotile-bearing serpentine. It also had as a range of amphibole-containing rocks, including blueschist, amphibolite schist, and eclogite, with at least 19 different regulated and non-regulated fibrous amphibole minerals identified. The extensive solid solution behavior of the amphiboles makes definitive identification difficult, though a scheme was created that allowed asbestos mineral fingerprinting of various areas of the project site.
Post-Stroke Patients with Moderate Function Have the Greatest Risk of Falls: A National Cohort Study
Authors: Wei Wycliffe Enli , De Silva Deidre Anne , Chang Hui Meng , Yao Jiali , Matchar David Bruce , Young Sherry Hsueh Yi , See Siew Ju , Lim Gek Hsiang , Wong Ting Hway , Venketasubramanian Narayanaswamy 
Published: December 2019

Abstract
Background
Stroke patients have increased risks of falls. We examined national registry data to evaluate the association between post-stroke functional level and the risk of low falls among post-stroke patients.
Methods
This retrospective cohort study analyzed data from national registries to examine the risk factors for post-stroke falls. Data for patients who suffered ischemic strokes and survived the index hospital admission was obtained from the Singapore National Stroke Registry and matched to the National Trauma Registry, from 2011 to 2015. The primary outcome measure was a low fall (fall height ≤0.5m). Competing risk analysis was performed to examine the association between functional level (by modified Rankin score [mRS] at discharge) and the risk of subsequent low falls.
Results
In all, 2,255 patients who suffered ischemic strokes had recorded mRS. The mean age was 66.6 years and 58.5% were men. By the end of 2015, 54 (2.39%) had a low fall while 93 (4.12%) died. After adjusting for potential confounders, mRS was associated with fall risk with an inverted U-shaped relationship. Compared to patients with a score of zero, the sub-distribution hazard ratio (SHR) increased to a maximum of 3.42 (95%CI:1.21-9.65, p=0.020) for patients with a score of 2. The SHR then declined to 2.45 (95%CI:0.85-7.12, p=0.098), 2.86 (95%CI:0.95-8.61, p=0.062) and 1.93 (95%CI:0.44-8.52, p=0.38) for patients with scores of 3, 4 and 5 respectively.
Conclusions
An inverted U-shaped relationship between functional status and fall risk was observed. This is consistent with the complex interplay between decreasing mobility (hence decreased opportunity to fall) and increasing susceptibility to falls. Fall prevention intervention could be targeted accordingly.
Prevalence and Mortality of Cryptococcal Disease in Adults with Advanced HIV in an Urban Tertiary Hospital in Sierra Leone: A Prospective Study
Authors: Lakoh Sulaiman , Rickman Hannah , Sesay Momodu , Kenneh Sartie , Burke Rachael M. , Baldeh Mamadu , Jiba Darlinda Fatmata , Tejan Yusuf Sheku , Boyle Sonia , Koroma Comfort , Deen Gibrilla Fadlu , Beynon Fenella 
Published: December 2019

Abstract
Background The global annual estimate for cryptococcal disease related deaths exceeds 180,000, with three fourth occurring in sub-Saharan Africa. The World Health Organization (WHO) recommends cryptococcal antigen (CrAg) screening in all HIV patients with CD4 count <100/µl. As there is no previous published study on the burden and impact of cryptococcal disease in Sierra Leone, research is needed to inform public health policies. We aimed to establish the seroprevalence and mortality of cryptococcal disease in adults with advanced HIV attending an urban tertiary hospital in Sierra Leone. MethodsA cross-sectional study design was used to screen consecutive adult (18 years or older) HIV patients at Connaught Hospital in Freetown, Sierra Leone with CD4 count below 100 cells/mm3 from January to April, 2018. Participants received a blood CrAg lateral flow assay (IMMY, Oklahoma, USA). All participants with a positive serum CrAg had lumbar puncture and cerebrospinal fluid (CSF) CrAg assay, and those with cryptococcal diseases had fluconazole monotherapy with eight weeks followed up. Data were entered into Excel and analysed in Stata version 13.0. Proportions, median and interquartile ranges were used to summarise the data. Fisher’s exact test was used to compare categorical variables. Results A total of 170 patients, with median age of 36 (IQR 30-43) and median CD4 count of 45 cells/mm3 (IQR 23-63) were screened. At the time of enrolment, 54% were inpatients, 51% were newly diagnosed with HIV, and 56% were either ART-naïve or newly initiated (≤ 30 days). Eight participants had a positive blood CrAg, giving a prevalence of 4.7% (95% CI: 2.4-9.2%). Of those with a positive CrAg, CSF CrAg was positive in five (62.5%). Five (62.5%) CrAg-positive participants died within the first month, while the remaining three were alive and established on ART at eight weeks. ConclusionA substantial prevalence of cryptococcal antigenaemia and poor outcome of cryptococcal disease were demonstrated in our study. The high mortality suggests a need for the HIV programme to formulate and implement policies on screening and pre-emptive fluconazole therapy for all adults with advanced HIV in Sierra Leone, and advocate for affordable access to effective antifungal therapies.
Quantitative Comparison of Two-dimensional and Three-dimensional Strain Measurement Using MRI Feature Tracking in Repair Fontan Patients and Normal Child Volunteers
Authors: Hu Liwei , Wang Qian , Gregory Barton P , Ouyang RongZhen , Sun Aimin , Guo Chen , Han Tongtong , Zhong Yumin 
Published: December 2019

Abstract
Purpose
The accuracy of 2D and 3D strain analyses was evaluated by comparing strain and cardiac function parameters in Fontan repair patients and normal child volunteers.
Methods
We retrospectively enrolled 32 patients with Fontan circulation and 32 child volunteers who had undergone clinical cardiac magnetic resonance (CMR) assessment of the dominant ventricle with a 1.5-Tesla MRI scanner. Global and regional strain (2D and 3D) of the dominant ventricle in both groups was assessed using CMR feature-tracking. Correlations between cardiac function and strain data were assessed using Pearson’s correlation coefficient values. The intraclass correlation coefficient (ICC) and coefficient of variation (CoV) were determined to evaluate repeatability and agreement.
Results: The 2D GLS showed significant differences between the Fontan repair patients and volunteers (-16.49 ± 5.00 vs. -19.49 ± 2.03; p = 0.002). The 2D GRS and 2D GCS showed no significant differences between two groups. 2D GRS: 38.96 ± 14.48 vs. 37.46 ± 7.77; 2D GCS: -17.64 ± 5.00 vs. -16.89 ± 2.96, respectively; p > 0.05). The 3D global radial strain (GRS), global circumferential strain (GCS), and global longitudinal strain (GLS) showed significant differences between the Fontan repair patients and volunteers (3D GRS: 36.35 ± 16.72 vs. 44.96 ± 9.98; 3D GLS: -8.86 ± 6.84 vs. -13.67 ± 2.44; 3D GCS: -13.70 ± 7.84 vs. -18.01 ± 1.78; p < 0.05, respectively). The ejection fraction (EF) and 3D GCS were significantly associated (r = -0.491, p = 0.004). The 3D GCS showed correlations with the indexed end-diastolic volume (EDV) (r = 0.523, p = 0.002) and indexed end-systolic volume (ESV) (r = 0.602, p < 0.001). 3D strain showed good reproducibility, with GCS showing the best inter-observer agreement (ICC=0.87 and CoV=5.15), followed by GLS (ICC=0.84 and CoV=5.36).
Conclusion:3D GCS is feasible, highly reproducible, and strongly correlated with conventional cardiac function measures. 3D GCS assessments may be useful for monitoring abnormal myocardial motion in patients with Fontan circulation.

Keywords Strain; Feature tracking; Fontan operation; Pediatric
Detection of Renal Hypoxia Configuration in Patients with Lupus Nephritis: A Primary Study Using Blood Oxygen Level‒Dependent MR Imaging
Authors: Zheng Zhengfeng , Wang Yanyan , Yan Tiekun , Jia Junya , Li Dong , Wei Li , Shang Wenya , Shi Huilan 
Published: December 2019

Abstract
Background Renal microstructure and function are closely associated with homeostasis of oxygenation. Analyzing renal blood oxygen level‒dependent (BOLD) magnetic resonance imaging (MRI) examination results will provide information on the biological status of the kidneys. The current study was performed to explore the hypoxia mode of the entire renal parenchyma in patients with lupus nephritis (LN). Methods Twenty-three adult patients with LN and eighteen healthy volunteers were recruited. R2* values were acquired through the use of the BOLD MRI analysis technique. The narrow rectangular region of interest was used to explore the hypoxia configuration in entire depths of renal parenchyma. Acquired sequential R2* data were fitted by using four categories of mathematic functions. The tendency of R2* data in both patients with LN and healthy volunteers was also compared through the use of repeated-measures analysis of variance. Results R2* data from the superficial cortex to deep medulla displayed two patterns, called a sharp uptrend style and a flat uptrend style. After sequential R2* data were fitted individually with the use of four mathematic formulas, the multiple-compartment Gaussian function showed the highest goodness of fit. Compared with two categories of R2* value styles, the R2* tendency of entire parenchyma in patients with LN was different from that in healthy volunteers. Conclusions Deep renal medullary oxygenation was not always overtly lower than oxygenation in superficial renal cortical zone. Renal parenchyma oxygenation manifestation could be described through the use of a Gaussian function model. The deoxygenation tolerance capability was damaged in patients with LN.
Shear Wave Elasticity by Tracing Total Nodule Showed High Reproducibility and Concordance with Fibrosis in Thyroid Cancer
Authors: Author) Myung Hi Yoo(New Corresponding , Author) Hye Jeong Kim(Former Corresponding , Choi In Ho , Park Suyeon , Kim Sang Jin , Park Hyeong Kyu , Byun Dong Won , Suh Kyoil 
Published: December 2019

Abstract
Background Although shear wave elastography (SWE) is reported to be useful in detecting malignant thyroid nodules, it shows a wide range of cut-off values of elasticity index (EI) in detecting malignant nodules. The cause of discrepancy remains unclear. Fibrosis of the tumors is known to increase the EI in SWE, and matching of SWE and surgical histopathology has not been fully illustrated in thyroid cancer. We aimed to evaluate the reproducibility of the new total nodular region of interest (ROI) method excluding the subjective features of focal circular ROI placement and to determine the lesion that causes the elevation of EI on SWE and on histopathology.
Methods A total of 29 thyroid cancers from 28 patients were included. We evaluated the reproducibility of EI in the new total nodular ROI using Q-Box Trace program and compared the EI in focal nodular ROI using a 3-mm circular area. We analyzed the correlation between fibrosis and EI.
Result The coefficient of variation (CV) of the intrarater assay was significantly lower in total nodular ROI than in focal nodular ROI within the image in rater 1 (1.7% vs. 13.4%, p<0.001) and in rater 2 (1.4% vs. 16.9%, p<0.001) and in different images in rater 1 (7.6% vs. 12.3%, p=0.040) and in rater 2 (7.5% vs. 19.8%, p=0.004). Moreover, CV of the interrater assay showed similar results (14.9% vs. 19%, p=0.030). Interrater intraclass correlation coefficient showed better agreement in total nodular ROI than in focal nodular ROI (0.863 vs. 0.783). The degree of fibrosis on histopathology showed significant correlations with EI (E Mean , p<0.001; E Max , p=0.027), and the location of fibrosis was concordant with the high EI area on SWE.
Conclusion Our study revealed that the new total nodular ROI method showed higher reproducibility and better agreement in intra- and interrater assay than the focal nodular ROI method, suggesting a valuable and standardized method in clinical practice. Moreover, our results showed that fibrosis in the histopathology increased EI on SWE and might lead to the discrepancy of the cut-off values in detecting thyroid cancer.
The predictive value of diaphragm ultrasound for weaning outcomes in critically ill children
Authors: Xue Yang , Zhang Zhen , Sheng Chu-Qiao , Li Yu-Mei , Jia Fei-Yong 
Published: December 2019

Abstract
Background: Multiple studies have shown that diaphragmatic ultrasound can better predict the outcome of weaning in adults. However, there are few studies focusing on children, leading to a lack of sufficient clinical evidence for the application of diaphragmatic ultrasound in children. The purpose of this study was to investigate the predictive value of diaphragm ultrasound for weaning outcomes in critically ill children.
Methods: The study included 50 cases whose mechanical ventilation (MV) time was >48 h, and all eligibles were divided into either the weaning success group (n = 39) or the weaning failure group (n = 11). Diaphragm thickness, diaphragmatic excursion (DE), and diaphragmatic thickening fraction (DTF) were measured in the zone of apposition. The maximum inspiratory pressure (PImax) was also recorded.
Results: The ventilatory treatment time ( P = 0.002) and length of PICU stay ( P = 0.013) in the weaning failure group was longer than the success group. Cut-off values of diaphragmatic measures associated with successful weaning were ≥21% for DTF with a sensitivity of 0.82 and a specificity of 0.81, whereas it was ≥0.86 cm H 2 O/kg for PImax with a sensitivity of 0.51 and a specificity of 0.82. The linear correlation analysis showed that DTF had a significant positive correlation with PImax in children ( P = 0.003).
Conclusions: Diaphragm ultrasound has potential value in predicting the weaning outcome of critically ill children. DTF and PImax presented better performance than other diaphragmatic parameters. However, DE has limited value in predicting weaning outcomes of children with MV.