bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of serum uric acid, morning home blood pressure and cardiovascular risk factors in a population with previous prehypertension: a cross-sectional study
Authors: Bawazier Lucky Aziza , Sja'bani Mochammad , Irijanto Fredie , Zulaela Zulaela , Widiatmoko Agus , Kholiq Abdul , Tomino Yasuhiko 
Published: September 2020

ObjectiveTo observe the changes in blood pressure (BP) over 10 years and to investigate current BP association to serum uric acid (SUA) levels and cardiovascular risk factors in the epidemiological data of a target group of patients with prehypertension in 2007.DesignCross-sectional study.SettingMlati Subdistrict, Sleman District, Yogyakarta Province, Indonesia.ParticipantsA total of 733 patients from ‘Mlati Study Database’ in 2007 were selected by simple random sampling using statistical software. Subjects had both physical and laboratory examinations.Outcome measuresMorning home BP and laboratory examination of urine (uric acid excretion and creatinine) and blood samples (SUA, blood urea nitrogen, creatinine, a lipid profile and fasting blood glucose levels).ResultsAbout 31.1% of 733 subjects with prehypertension became hypertensive after 10 years, 24.6% returned to normal tension and the rest of it remained in prehypertensive state. Mean (SD) of SUA levels in 2017 was significantly higher in men than in women (5.78 (1.25) mg/dL vs 4.52 (1.10) mg/dL, p<0.001). Furthermore, men tended to have high-normal (5–7 mg/dL) or high SUA levels (≥7 mg/dL) compared with women (p<0.001, Relative Risk (RR)=2.60). High-normal and high SUA levels in population with a history of prehypertension were significantly associated with current prehypertension and hypertension only in women (p=0.001, RR=1.21). Age and body mass index was found to be significantly associated with both systolic and diastolic BP in men, but only with systolic BP in women. Fasting blood glucose and SUA levels were significantly associated with systolic and diastolic BP only in women.ConclusionWe concluded that after 10 years, of 733 subjects with prehypertension, 31.1% became hypertensive. The SUA levels in men are significantly higher than those in women. Moreover, high-normal and high SUA levels were significantly associated with prehypertension and hypertension in women but not in men.
Use of real-world data to study health services utilisation and comorbidities in long-term breast cancer survivors (the SURBCAN study): study protocol for a longitudinal population-based cohort study
Authors: Jansana Anna , Del Cura Isabel , Prados-Torres Alexandra , Sanz Cuesta Teresa , Poblador-Plou Beatriz , Gimeno Miguel A , Lanzuela Manuela , Ibañez Berta , Tamayo Ibai , Moreno-Iribas Conchi , Padilla-Ruiz María , Redondo Maximino , Comas Mercè , Domingo Laia , Díaz-Holgado Antonio , Salamanca Francisco Javier , Castells Xavier , Sala Maria 
Published: September 2020

IntroductionBreast cancer has become a chronic disease due to survival improvement and the need to monitor the side effects of treatment and the disease itself. The aim of the SURBCAN study is to describe comorbidity, healthcare services use and adherence to preventive recommendations in long-term breast cancer survivors and to compare them with those in women without this diagnosis in order to improve and adapt the care response to this group of survivors.Methods and analysisPopulation-based retrospective cohort study using real-world data from cancer registries and linked electronic medical records in five Spanish regions. Long-term breast cancer survivors diagnosed between 2000 and 2006 will be identified and matched by age and administrative health area with women without this diagnosis. Sociodemographic and clinical variables including comorbidities and variables on the use of health services between 2012 and 2016 will be obtained from databases in primary and hospital care. Health services use will be assessed through the annual number of visits to primary care professionals and to specialists and through annual imaging and laboratory tests. Factors associated with healthcare utilisation and comorbidities will be analysed using multilevel logistic regression models. Recruitment started in December 2018.Ethics and disseminationThis study was approved by the Ethics Committee of Parc de Salut Mar. The results of the study will be published in a peer-reviewed journal and will be presented at national and international scientific conferences and at patient associations.Trial registration numberThis protocol is registered in Clinical Trials.gov (identifier: NCT03846999).
The dedicated iron deficiency anaemia clinic: a 15-year experience
Authors: Stone Helen , Almilaji Orouba , John Christopher , Smith Carla , Surgenor Susan L , Ayres Lachlan , Williams Elizabeth J , Snook Jonathon 
Published: September 2020

ObjectiveTo report our cumulative experience from a dedicated iron deficiency anaemia (IDA) clinic over the last 15 years—with particular emphasis on referral rate, uptake of investigation, impact on endoscopy services, diagnostic yield of gastrointestinal (GI) investigation and the issue of recurrent IDA.MethodA series of analyses of a register of 2808 referrals to the Poole IDA clinic between 2004 and 2018.ResultsThe study population of 2808 had a sex ratio of 1.9 (female/male ratio) and a median age of 72 years (IQR: 60–79). A rising referral rate over the study period appears to be plateauing at around 2 cases per 1000 population per annum. On the basis of a snapshot audit, investigation of IDA may now account for over 20% of all diagnostic endoscopies.Overall, 86% of cases underwent examination of the upper and lower GI tract. Significant GI pathology was identified in 27% of the investigated cohort. Adenocarcinoma of the upper or lower GI tract was found in 8.3%, the majority in the right colon. The prevalence of recurrent IDA was estimated at 12.4%, and the results of investigation of this subgroup are reported.ConclusionUnexplained IDA is common, particularly in those over 60 years, and may be the first indication of underlying GI malignancy in over 8% of cases. Unresolved challenges include accommodating the resulting endoscopy workload, establishing a risk/benefit ratio for investigating those with major comorbidities and the management of recurrent IDA.
BCL2andBCL6atypical/unbalanced gene rearrangements in diffuse large B-cell lymphoma are indicators of an aggressive clinical course
Authors: Tourneret Alicia , Alame Melissa , Rigau Valerie , Bauchet Luc , Fabbro Michel , De Oliveira Laura , Cacheux Valere , Costes Valerie , Lacheretz-Szablewski Vanessa 
Published: September 2020

AimsDiffuse large B-cell lymphoma (DLBCL) is the most common type of aggressive non-Hodgkin's lymphoma that represents a heterogeneous group of disease that is differentially characterised by clinical, molecular and cytogenetic features.MYC,BCL2andBCL6gene rearrangements have been identified as prognostic factors in DLBCL, especially forMYC. Nevertheless the frequency and effect of atypical/unbalancedBCL6, BCL2andMYCtranslocations in DLBCL is not fully documented. Here, we aimed to analyse those atypical/unbalanced rearrangements in DLBCL and to assess their prognostic impact.MethodsWe collected tumour tissue and clinical data from 97 DLBCL and used interphase fluorescence in situ hybridisation (FISH) with break-apart probe to characteriseBCL6, BCL2andMYCgene pattern.Results19 of 97 (19,6%) cases of DLBCL had atypical/ unbalanced gene rearrangements (14 involvingBCL6gene, 5 involvingBCL2gene and none involvingMYCgene). Compared with patients with simple gene rearrangement and patients without cytogenetic abnormality, patients with atypical/unbalanced gene rearrangement were in an unfavourable risk group by the International Prognostic Index (p=0039), died of disease (p=0012), harboured relapse or progression (p=0011) and had shorter overall (p=0,04), relapse free (p=0029) and event free (p=0026) survival.ConclusionsWe showed that patients with DLBCL withBCL2orBCL6atypical/unbalanced rearrangements constituted a group of patients with poor outcome. We also underlined the importance of FISH analyses, easily feasible in routine practise, at diagnosis of DLBCL to detect the rather frequent and clinically significant atypical/unbalanced aberrations of these genes.
Effectiveness of providing university students with a mindfulness-based intervention to increase resilience to stress: 1-year follow-up of a pragmatic randomised controlled trial
Authors: Galante Julieta , Stochl Jan , Dufour Géraldine , Vainre Maris , Wagner Adam Peter , Jones Peter Brian 
Published: September 2020

BackgroundThere is concern that increasing demand for student mental health services reflects deteriorating student well-being. We designed a pragmatic, parallel, single-blinded randomised controlled trial hypothesising that providing mindfulness courses to university students would promote their resilience to stress up to a year later. Here we present 1-year follow-up outcomes.MethodsUniversity of Cambridge students without severe mental illness or crisis were randomised (1:1, remote software-generated random numbers), to join an 8-week mindfulness course adapted for university students (Mindfulness Skills for Students (MSS)), or to mental health support as usual (SAU).ResultsWe randomised 616 students; 53% completed the 1-year follow-up questionnaire. Self-reported psychological distress and mental well-being improved in the MSS arm for up to 1 year compared to SAU (p<0.001). Effects were smaller than during the examination period. No significant differences between arms were detected in the use of University Counselling Service and other support resources, but there was a trend for MSS participants having milder needs. There were no differences in students’ workload management; MSS participants made more donations. Home practice had positive dose–response effects; few participants meditated. No adverse effects related to self-harm, suicidality or harm to others were detected.ConclusionLoss to follow-up is a limitation, but evidence suggests beneficial effects on students’ average psychological distress that last for at least a year. Effects are on average larger at stressful times, consistent with the hypothesis that this type of mindfulness training increases resilience to stress.Trial registration numberACTRN12615001160527.
Occupational physical activity, not leisure-time physical activity, is associated with increased high-sensitivity C reactive protein levels
Authors: Lee Jongin , Kim Hyoung-Ryoul , Jang Tae-Won , Lee Dong-Wook , Lee Yu Min , Kang Mo-Yeol 
Published: September 2020

ObjectiveThis study aims to explore the association between physical activity and high-sensitivity C reactive protein, based on different types of physical activity—occupational and leisure time.MethodsUsing cross-sectional data from the Korea National Health and Nutrition Examination Survey 2015–2018, we explored the association between different types of self-reported physical activity and high levels of high-sensitivity C reactive protein (>3 mg/L). We estimated the ORs for high-level high-sensitivity C reactive protein using multiple logistic regression models after adjusting for covariates from 12 970 eligible subjects (mean age 44.8).ResultsCompared with subjects who did not engage in moderate-to-vigorous level of occupational physical activity (OPA), the group that engaged in moderate-to-vigorous level of OPA showed a significantly high OR (1.32, 95% CI (1.03 to 1.69)), whereas the group that engaged in moderate-to-vigorous level of leisure-time physical activity (LPA) yielded a low OR (0.84, 95% CI (0.69 to 1.01)). The group that engaged in moderate-to-vigorous level of OPA but not LPA showed a significantly high OR (1.76, 95% CI (1.27 to 2.45)) compared with subjects who engaged in moderate-to-vigorous level of LPA but not in OPA.ConclusionsOPA is directly associated with high C reactive protein levels, suggesting that it increases the risk of inflammation.
Cryogenic characterization of a $$\hbox {LiAlO}_{2}$$ crystal and new results on spin-dependent dark matter interactions with ordinary matter
Authors: Abdelhameed A. H. , Angloher G. , Bauer P. , Bento A. , Bertoldo E. , Breier R. , Bucci C. , Canonica L. , D’Addabbo A. , Di Lorenzo S. , Erb A. , Feilitzsch F. V. , Iachellini N. Ferreiro , Fichtinger S. , Fuchs D. , Fuss A. , Ghete V. M. , Garai A. , Gorla P. , Hauff D. , Ješkovský M. , Jochum J. , Kaizer J. , Kaznacheeva M. , Kinast A. , Kluck H. , Kraus H. , Langenkämper A. , Mancuso M. , Mokina V. , Mondragon E. , Olmi M. , Ortmann T. , Pagliarone C. , Palušová V. , Pattavina L. , Petricca F. , Potzel W. , Povinec P. , Pröbst F. , Reindl F. , Rothe J. , Schäffner K. , Schieck J. , Schipperges V. , Schmiedmayer D. , Schönert S. , Schwertner C. , Stahlberg M. , Stodolsky L. , Strandhagen C. , Strauss R. , Usherov I. , Wagner F. , Willers M. , Zema V. , Zeman J. , Brützam M. , Ganschow S. 
Published: September 2020

AbstractIn this work, a first cryogenic characterization of a scintillating $$\hbox {LiAlO}_{2}$$

LiAlO
2

single crystal is presented. The results achieved show that this material holds great potential as a target for direct dark matter search experiments. Three different detector modules obtained from one crystal grown at the Leibniz-Institut für Kristallzüchtung (IKZ) have been tested to study different properties at cryogenic temperatures. Firstly, two 2.8 g twin crystals were used to build different detector modules which were operated in an above-ground laboratory at the Max Planck Institute for Physics (MPP) in Munich, Germany. The first detector module was used to study the scintillation properties of $$\hbox {LiAlO}_{2}$$

LiAlO
2

at cryogenic temperatures. The second achieved an energy threshold of ($$213.02\pm 1.48$$

213.02
±
1.48

) eV which allows setting a competitive limit on the spin-dependent dark matter particle-proton scattering cross section for dark matter particle masses between $$350\,\hbox {MeV/c}^{2}$$

350

MeV/c
2

and $$1.50\,\hbox {GeV/c}^{2}$$

1.50

GeV/c
2

. Secondly, a detector module with a 373 g $$\hbox {LiAlO}_{2}$$

LiAlO
2

crystal as the main absorber was tested in an underground facility at the Laboratori Nazionali del Gran Sasso (LNGS): from this measurement it was possible to determine the radiopurity of the crystal and study the feasibility of using this material as a neutron flux monitor for low-background experiments.
Measurements of $${\Xi }{^-} $$ and $$\overline{\Xi }{^+} $$ production in proton–proton interactions at $$\sqrt{s_{NN}}$$ = 17.3 $$\hbox {Ge}\hbox {V}$$ in the NA61/SHINE experiment
Authors: Aduszkiewicz A. , Andronov E. V. , Antićić T. , Babkin V. , Baszczyk M. , Bhosale S. , Blondel A. , Bogomilov M. , Brandin A. , Bravar A. , Bryliński W. , Brzychczyk J. , Buryakov M. , Busygina O. , Bzdak A. , Cherif H. , Ćirković M. , Csanad M. , Cybowska J. , Czopowicz T. , Damyanova A. , Davis N. , Deliyergiyev M. , Deveaux M. , Dmitriev A. , Dominik W. , Dorosz P. , Dumarchez J. , Engel R. , Feofilov G. A. , Fields L. , Fodor Z. , Garibov A. , Gaździcki M. , Golosov O. , Golovatyuk V. , Golubeva M. , Grebieszkow K. , Guber F. , Haesler A. , Igolkin S. N. , Ilieva S. , Ivashkin A. , Johnson S. R. , Kadija K. , Kargin N. , Kashirin E. , Kiełbowicz M. , Kireyeu V. A. , Klochkov V. , Kolesnikov V. I. , Kolev D. , Korzenev A. , Kovalenko V. N. , Kowalski S. , Koziel M. , Krasnoperov A. , Kucewicz W. , Kuich M. , Kurepin A. , Larsen D. , László A. , Lazareva T. V. , Lewicki M. , Łojek K. , Lyubushkin V. V. , Maćkowiak-Pawłowska M. , Majka Z. , Maksiak B. , Malakhov A. I. , Marcinek A. , Marino A. D. , Marton K. , Mathes H.-J. , Matulewicz T. , Matveev V. , Melkumov G. L. , Merzlaya A. O. , Messerly B. , Mik Ł. , Morozov S. , Mrówczyński S. , Nagai Y. , Naskręt M. , Ozvenchuk V. , Paolone V. , Petukhov O. , Płaneta R. , Podlaski P. , Popov B. A. , Porfy B. , Posiadała-Zezula M. , Prokhorova D. S. , Pszczel D. , Puławski S. , Puzović J. , Ravonel M. , Renfordt R. , Röhrich D. , Rondio E. , Roth M. , Rumberger B. T. , Rumyantsev M. , Rustamov A. , Rybczynski M. , Rybicki A. , Sadovsky A. , Schmidt K. , Selyuzhenkov I. , Seryakov A. Yu. , Seyboth P. , Słodkowski M. , Staszel P. , Stefanek G. , Stepaniak J. , Strikhanov M. , Ströbele H. , Šuša T. , Taranenko A. , Tefelska A. , Tefelski D. , Tereshchenko V. , Toia A. , Tsenov R. , Turko L. , Ulrich R. , Unger M. , Uzhva D. , Valiev F. F. , Veberič D. , Vechernin V. V. , Wickremasinghe A. , Włodarczyk Z. , Wojcik K. , Wyszyński O. , Zimmerman E. D. , Zwaska R. 
Published: September 2020

AbstractThe production of $$\Xi (1321)^{-}$$

Ξ

(
1321
)

-

and $$\overline{\Xi }(1321)^{+}$$

Ξ
¯

(
1321
)

+

hyperons in inelastic p+p interactions is studied in a fixed target experiment at a beam momentum of 158 $$\hbox {Ge}\hbox {V}\!/\!c$$

Ge

/

c

. Double differential distributions in rapidity $${y}$$
y
and transverse momentum $$p_{T}$$

p
T

are obtained from a sample of 33M inelastic events. They allow to extrapolate the spectra to full phase space and to determine the mean multiplicity of both $${\Xi }{^-} $$

Ξ

-

and $$\overline{\Xi }{^+} $$

Ξ
¯

+

. The rapidity and transverse momentum spectra are compared to transport model predictions. The $${\Xi }{^-} $$

Ξ

-

mean multiplicity in inelastic p+p interactions at 158 $$\hbox {Ge}\hbox {V}\!/\!c$$

Ge

/

c

is used to quantify the strangeness enhancement in A+A collisions at the same centre-of-mass energy per nucleon pair.
Gravitational deflection of massive particles in Schwarzschild-de Sitter spacetime
Authors: He Guansheng , Zhou Xia , Feng Zhongwen , Mu Xueling , Wang Hui , Li Weijun , Pan Chaohong , Lin Wenbin 
Published: September 2020

AbstractIn this paper, the gravitational deflection of a relativistic massive neutral particle in the Schwarzschild-de Sitter spacetime is studied via the Rindler–Ishak method in the weak-field limit. When the initial velocity$$v_0$$v0of the particle tends to the speed of light, the result is consistent with that obtained in the previous work for the light-bending case. Our result is reduced to the Schwarzschild deflection angle of massive particles up to the second order, if the contributions from the cosmological constant$$\varLambda $$Λare dropped. The observable correctional effects due to the deviation of$$v_0$$v0from light speed on the$$\varLambda $$Λ-induced contributions to the deflection angle of light are also analyzed.
Strong decays of the $$\varXi (1620)^0$$ as a $$\varLambda {\bar{K}}$$ and $$\varSigma {\bar{K}}$$ molecule
Authors: Huang Yin , Geng Lisheng 
Published: September 2020

AbstractIn this work, we study the strong decays of the newly observed $$\varXi (1620)^0$$

Ξ

(
1620
)

0

assuming that it is a meson-baryon molecular state of $$\varLambda {\bar{K}}$$

Λ

K

¯

and $$\varSigma {\bar{K}}$$

Σ

K

¯

. We consider four possible spin-parity assignments $$J^P=1/2^{\pm }$$

J
P

=
1
/

2
±

and $$3/2^{\pm }$$

3
/

2
±

for the $$\varXi (1620)^0$$

Ξ

(
1620
)

0

, and evaluate its partial decay width into $$\varXi \pi $$

Ξ
π

and $$\varXi \pi \pi $$

Ξ
π
π

via hadronic loops with the help of effective Lagrangians. In comparison with the Belle data, the calculated decay width favors the spin-party assignment $$1/2^-$$

1
/

2
-

while the other spin-parity assignments do not yield a decay width consistent with data in the molecule picture. We find that about 52–68% of the total width comes from the $${\bar{K}}\varLambda $$

K

¯

Λ

channel, while the rest is provided by the $${\bar{K}}\varSigma $$

K

¯

Σ

channel. As a result, both channels are important in explaining the strong decay of the $$\varXi (1620)^0$$

Ξ

(
1620
)

0

. In addition, the transition $$\varXi (1620)^0\rightarrow \pi \varXi $$

Ξ

(
1620
)

0

→
π
Ξ

is the main decay channel in the $$J^{P}=1/2^{-}$$

J
P

=
1
/

2
-

case, which almost saturates the total width. These information are helpful to further understand the nature of the $$\varXi (1620)^0$$

Ξ

(
1620
)

0

.
Calculation of h1 of some Anderson t-motives
Authors: Ehbauer S. , Grishkov A. , Logachev D. 
Published: September 2020

We consider Anderson [Formula: see text]-motives [Formula: see text] of dimension 2 and rank 4 defined by some simple explicit equations parameterized by [Formula: see text] matrices. We use methods of explicit calculation of [Formula: see text] — the dimension of their cohomology group [Formula: see text] ([Formula: see text] dimension of the lattice of their dual [Formula: see text]-motive [Formula: see text]) developed in our earlier paper. We calculate [Formula: see text] for [Formula: see text] defined by all matrices of the form [Formula: see text], and by some matrices of the form [Formula: see text]. These methods permit to make analogous calculations for most (probably all) [Formula: see text]-motives. [Formula: see text] of all Anderson [Formula: see text]-motives [Formula: see text] under consideration satisfy the inequality [Formula: see text], while in all known examples we have [Formula: see text]. Do there exist [Formula: see text] of this type having [Formula: see text]? We do not know, this is a subject of further research.
Tunica-Specific Transcriptome of Abdominal Aortic Aneurysm and the Effect of Intraluminal Thrombus, Smoking, and Diameter Growth Rate
Authors: Lindquist Liljeqvist Moritz , Hultgren Rebecka , Bergman Otto , Villard Christina , Kronqvist Malin , Eriksson Per , Roy Joy 
Published: September 2020

Objective:
There is no medical treatment to prevent abdominal aortic aneurysm (AAA) growth and rupture, both of which are linked to smoking. Our objective was to map the tunica-specific pathophysiology of AAA with consideration of the intraluminal thrombus, age, and sex, and to subsequently identify which mechanisms were linked to smoking and diameter growth rate.

Approach and Results:
Microarray analyses were performed on 246 samples from 76 AAA patients and 13 controls. In media and adventitia, there were 5889 and 2701 differentially expressed genes, respectively. Gene sets related to adaptive and innate immunity were upregulated in both tunicas. Media-specific gene sets included increased matrix disassembly and angiogenesis, as well as decreased muscle cell development, contraction, and differentiation. Genes implicated in previous genome-wide association studies were dysregulated in media. The intraluminal thrombus had a pro-proteolytic and proinflammatory effect on the underlying media. Active smoking resulted in increased inflammation, oxidative stress, and angiogenesis in all tissues and enriched lipid metabolism in adventitia. Processes enriched with active smoking in control aortas overlapped to a high extent with those differentially expressed between AAAs and controls. The AAA diameter growth rate (n=24) correlated with T- and B-cell expression in media, as well as lipid-related processes in the adventitia.

Conclusions:
This tunica-specific analysis of gene expression in a large study enabled the detection of features not previously described in AAA disease. Smoking was associated with increased expression of aneurysm-related processes, of which adaptive immunity and lipid metabolism correlated with growth rate.