bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nest association between two predators as a behavioral response to the low density of rodents
Authors: Pokrovsky Ivan , Ehrich Dorothée , Fufachev Ivan , Ims Rolf A , Kulikova Olga , Sokolov Aleksandr , Sokolova Natalia , Sokolov Vasiliy , Yoccoz Nigel G 
Published: November 2019

AbstractMany birds nest in association with aggressive birds of other species to benefit from their protection against predators. We hypothesized that the protective effect also could extend to foraging resources, whereby the resultant resource-enriched habitats near a nest of aggressive raptors could be an alternative cause of associations between nesting bird species with non-overlapping foraging niches. In the Arctic, the Rough-legged Hawk (Buteo lagopus) and the Peregrine Falcon (Falco peregrinus) are 2 raptor species with non-overlapping food resources that have been reported to nest sometimes in close proximity. Since nesting Peregrine Falcons are very aggressive, they may protect the small rodent prey near their nests from predation, and Rough-legged Hawks could use these hot spots as a nesting territory. In 2 regions in low Arctic Russia we found that (1) the nesting territories of Peregrine Falcons were indeed enriched with small rodents as compared to control areas, (2) the probability of nest association between the 2 raptors increased when rodent abundance was generally low in the region where hawks did not use alternative prey, and (3) hawk reproductive success increased when nesting close to Peregrine Falcons. These results suggest that implications of aggressive nest site defense in birds in certain cases may involve more mechanisms than previously explored. A key ecological process in tundra, rodent population cycles, may explain the occurrence and adaptive significance of a specific behavior pattern, the nesting association between 2 raptor species.
Affiliation history and age similarity predict alliance formation in adult male bottlenose dolphins
Authors: Gerber Livia , Connor Richard C , King Stephanie L , Allen Simon J , Wittwer Samuel , Bizzozzero Manuela R , Friedman Whitney R , Kalberer Stephanie , Sherwin William B , Wild Sonja , Willems Erik P , Krützen Michael 
Published: November 2019

Abstract
Male alliances are an intriguing phenomenon in the context of reproduction since, in most taxa, males compete over an indivisible resource, female fertilization. Adult male bottlenose dolphins (Tursiops aduncus) in Shark Bay, Western Australia, form long-term, multilevel alliances to sequester estrus females. These alliances are therefore critical to male reproductive success. Yet, the long-term processes leading to the formation of such complex social bonds are still poorly understood. To identify the criteria by which male dolphins form social bonds with other males, we adopted a long-term approach by investigating the ontogeny of alliance formation. We followed the individual careers of 59 males for 14 years while they transitioned from adolescence (8–14 years of age) to adulthood (15–21 years old). Analyzing their genetic relationships and social associations in both age groups, we found that the vast majority of social bonds present in adolescence persisted through time. Male associations in early life predict alliance partners as adults. Kinship patterns explained associations during adolescence but not during adulthood. Instead, adult males associated with males of similar age. Our findings suggest that social bonds among peers, rather than kinship, play a central role in the development of adult male polyadic cooperation in dolphins.
A taxonomic survey of monocotylar Apiaceae and the implications of their morphological diversity for their systematics and evolution
Authors: Kljuykov Eugene V , Petrova Svetlana E , Degtjareva Galina V , Zakharova Ekaterina A , Samigullin Tahir H , Tilney Patricia M 
Published: November 2019

AbstractIn Apiaceae, embryos of most species have two cotyledons, but some species are consistently monocotylar. Traditionally, the monocotyly has been considered as taxonomically important at the generic level, despite its presumably multiple origins in the family. In this study, a survey of the published literature and our new findings on cotyledon number, embryo and seedling morphology and nrDNA ITS sequence data are presented to provide modern insights into the taxonomic distribution and phylogenetic relationships of monocotylar taxa. A molecular phylogenetic tree representing much of the diversity of monocotylar Apiaceae was produced to re-evaluate the potential implication of monocotyly for systematics and to elucidate its evolutionary significance in the family. Our data document the presence of monocotylar seedlings in 59 species representing 15 genera, in three species and one genus (Postiella) of which monocotylar seedlings are reported for the first time. Analysis of ITS sequence data indicates that monocotyly in Apiaceae has arisen independently in at least seven different lineages encompassing five of 41 major clades of subfamily Apioideae, but not in early-diverging lineages. Parallel evolution has resulted in a remarkable morphological similarity in monocotylar embryo and seedling organization, especially in the proportion of the cotyledon length to the axis of the embryo and the multifunctional cotyledonary tube in the seedling. These features could be considered as adaptations to a geophilic life form, as all monocotylar species are perennial herbs with tuberous underground organs distributed mainly in the Ancient Mediterranean region. The single cotyledon in Apiaceae, as in most other monocotyledonous eudicots, could be interpreted as two united cotyledons (syncotyly), but further developmental studies are needed to test this hypothesis.
Postoperative delirium is associated with increased plasma neurofilament light
Authors: Casey Cameron P , Lindroth Heidi , Mohanty Rosaleena , Farahbakhsh Zahra , Ballweg Tyler , Twadell Sarah , Miller Samantha , Krause Bryan , Prabhakaran Vivek , Blennow Kaj , Zetterberg Henrik , Sanders Robert D 
Published: November 2019

Abstract
While delirium is associated with cognitive decline and dementia, there is limited evidence to support causality for this relationship. Clarification of how delirium may cause cognitive decline, perhaps through evidence of contemporaneous neuronal injury, would enhance plausibility for a causal relationship. Dose-dependence of neuronal injury with delirium severity would further enhance the biological plausibility for this relationship. We tested whether delirium is associated with neuronal injury in 114 surgical patients recruited to a prospective biomarker cohort study. Patients underwent perioperative testing for changes in neurofilament light, a neuronal injury biomarker, as well as a panel of 10 cytokines, with contemporaneous assessment of delirium severity and incidence. A subset of patients underwent preoperative MRI. Initially we confirmed prior reports that neurofilament light levels correlated with markers of neurodegeneration [hippocampal volume (ΔR2 = 0.129, P = 0.015)] and white matter changes including fractional anisotropy of white matter (ΔR2 = 0.417, P &lt; 0.001) with similar effects on mean, axial and radial diffusivity) in our cohort and that surgery was associated with increasing neurofilament light from preoperative levels [mean difference (95% confidence interval, CI) = 0.240 (0.178, 0.301) log10 (pg/ml), P &lt; 0.001], suggesting putative neuronal injury. Next, we tested the relationship with delirium. Neurofilament light rose more sharply in participants with delirium compared to non-sufferers [mean difference (95% CI) = 0.251 (0.136, 0.367) log10 (pg/ml), P &lt; 0.001]. This relationship showed dose-dependence, such that neurofilament light rose proportionately to delirium severity (ΔR2 = 0.199, P &lt; 0.001). Given that inflammation is considered an important driver of postoperative delirium, next we tested whether neurofilament light, as a potential marker of neurotoxicity, may contribute to the pathogenesis of delirium independent of inflammation. From a panel of 10 cytokines, the pro-inflammatory cytokine IL-8 exhibited a strong correlation with delirium severity (ΔR2 = 0.208, P &lt; 0.001). Therefore, we tested whether the change in neurofilament light contributed to delirium severity independent of IL-8. Neurofilament light was independently associated with delirium severity after adjusting for the change in inflammation (ΔR2 = 0.040, P = 0.038). These data suggest delirium is associated with exaggerated increases in neurofilament light and that this putative neurotoxicity may contribute to the pathogenesis of delirium itself, independent of changes in inflammation.
Clinicopathological correlations of sural nerve biopsies in TTR Val30Met familial amyloid polyneuropathy
Authors: Fernandes Armindo , Coelho Teresa , Rodrigues Aurora , Felgueiras Helena , Oliveira Pedro , Guimarães António , Melo-Pires Manuel , Taipa Ricardo 
Published: November 2019

AbstractFamilial amyloid polyneuropathy with the substitution of methionine for valine at position 30 in the TTR gene is the most common type of hereditary transthyretin amyloidosis. Although several authors have previously reported a size-dependent fibre loss, predominantly involving unmyelinated and small-diameter myelinated fibres, the mechanisms of nerve fibre loss have not been fully understood. In this study, we establish the morphometric pattern of peripheral neuropathy in patients with familial amyloid polyneuropathy and asymptomatic mutation carriers in the biopsies from our archive and correlated the pathological findings with clinical features. A total of 98 patients with familial amyloid polyneuropathy and 37 asymptomatic mutation carriers (TTR Val30Met mutation), aged between 17 and 84 years, who underwent sural nerve biopsy between 1981 and 2017 at Centro Hospitalar Universitário do Porto were studied. Thirty-one controls were included for comparison. The median age at nerve biopsy was 26.0 [interquartile range = 23.5–39.5] years for asymptomatic mutation carriers, 45.0 [35.0–60.0] years for patients with familial amyloid polyneuropathy and 44.0 [30.0–63.0] years for controls. The median duration between nerve biopsy and symptoms’ onset was 7.0 [3.3–11.8] years (range: 1–27 years) in the asymptomatic carriers. Most patients were in an earlier disease stage (93% with a polyneuropathy disability scale ≤2). Patients had loss of small and myelinated fibres compared with both asymptomatic carriers and controls (P &lt; 0.001), whereas asymptomatic carriers showed loss of small myelinated fibres when compared with controls (P &lt; 0.05). The loss of myelinated fibres increased with disease progression (P &lt; 0.001), and patients in more advanced clinical stage showed more frequent amyloid deposition in the nerve (P = 0.001). There was a positive correlation between large myelinated fibre density and time to symptoms’ onset in the asymptomatic carriers that developed early-onset form of the disease (r = 0.52, P &lt; 0.01). In addition, asymptomatic carriers with amyloid deposition already present in sural nerve biopsies developed symptoms earlier than those with no amyloid (P &lt; 0.01). In conclusion, this study confirms that the loss of small fibre size is an initial event in familial amyloid polyneuropathy, already present in asymptomatic gene carriers, starting several years before the onset of symptoms. We show for the first time that large myelinated fibres’ loss and amyloid deposition are pathological features that correlate independently with short period to the onset of symptoms for asymptomatic carriers that developed early-onset form of the disease. These findings are therapeutically relevant, as it would allow for a better interpretation of the role of disease-modifying agents in transthyretin familial amyloid polyneuropathy.
Host Plant and Thermal Stress Induce Supernumerary Instars in Caterpillars
Authors: Abarca Mariana , Lill John T , Weiss Martha R 
Published: November 2019

AbstractEnvironmental stressors may induce variation in the number of larval instars of holometabolous insects. Host plant quality and ambient temperature can both induce this life history shift in the silver-spotted skipper, Epargyreus clarus (Cramer 1775) (Lepidoptera: Hesperiidae). To better understand this phenomenon, we raised larvae on high-quality (kudzu) or low-quality (wisteria) host plants in growth chambers under three temperature regimes (20, 26, and 32°C) that were either constant or diurnally fluctuating (T ± 5°C), and recorded survival and incidence of supernumerary instars. Larvae feeding on the low-quality host and/or experiencing thermal stress were more likely to show supernumerary development (SD). A subset of treatments yielded a mix of SD and TD (typical development) individuals, allowing for comparisons between phenotypes. Under the most stressful treatment (20 ± 5°C, wisteria), development time was 9 days longer in SD than in TD individuals; by contrast, at typical summer temperatures (26 ± 5°C), also on wisteria, total development time did not differ between these two phenotypes. Head capsules of both second and third instars were smaller in SD individuals. A retrospective logistic regression analysis indicated that third-instar head capsule size could be used to predict expression of the SD phenotype. By the ultimate instar, however, there were no detectable differences in head capsule size, and SD and TD individuals did not differ in pupal mass, strongly suggesting that the SD phenotype functions as a compensatory mechanism allowing E. clarus larvae to achieve the same size at metamorphosis (a strong fitness correlate) as TD larvae.
Chromosomal-level reference genome of Chinese peacock butterfly (Papilio bianor) based on third-generation DNA sequencing and Hi-C analysis
Authors: Lu Sihan , Yang Jie , Dai Xuelei , Xie Feiang , He Jinwu , Dong Zhiwei , Mao Junlai , Liu Guichun , Chang Zhou , Zhao Ruoping , Wan Wenting , Zhang Ru , Li Yuan , Wang Wen , Li Xueyan 
Published: November 2019

Abstract

Background
Papilio bianor Cramer, 1777 (commonly known as the Chinese peacock butterfly) (Insecta, Lepidoptera, Papilionidae) is a widely distributed swallowtail butterfly with a wide number of geographic populations ranging from the southeast of Russia to China, Japan, India, Vietnam, Myanmar, and Thailand. Its wing color consists of both pigmentary colored scales (black, reddish) and structural colored scales (iridescent blue or green dust). A high-quality reference genome of P. bianor is an important foundation for investigating iridescent color evolution, phylogeography, and the evolution of swallowtail butterflies.

Findings
We obtained a chromosome-level de novo genome assembly of the highly heterozygous P. bianor using long Pacific Biosciences sequencing reads and high-throughput chromosome conformation capture technology. The final assembly is 421.52 Mb on 30 chromosomes (29 autosomes and 1 Z sex chromosome) with 13.12 Mb scaffold N50. In total, 15,375 protein-coding genes and 233.09 Mb of repetitive sequences were identified. Phylogenetic analyses indicated that P. bianor separated from a common ancestor of swallowtails ~23.69–36.04 million years ago. Demographic history suggested that the population expansion of this species from the last interglacial period to the last glacial maximum possibly resulted from its decreased natural enemies and its adaptation to climate change during the glacial period.

Conclusions
We present a high-quality chromosome-level reference genome of P. bianor using long-read single-molecule sequencing and Hi-C–based chromatin interaction maps. Our results lay the foundation for exploring the genetic basis of special biological features of P. bianor and also provide a useful data source for comparative genomics and phylogenomics among butterflies and moths.
Sigma-1 receptor is a key genetic modulator in amyotrophic lateral sclerosis
Authors: Couly Simon , Khalil Bilal , Viguier Véronique , Roussel Julien , Maurice Tangui , Liévens Jean-Charles 
Published: November 2019

Abstract
Sigma-1 receptor (S1R) is an endoplasmic reticulum (ER) chaperone that regulates mitochondrial respiration but also controls cellular defense against ER and oxidative stress. This makes S1R a potential therapeutic target in amyotrophic lateral sclerosis (ALS). Especially, as a missense mutation E102Q in S1R has been reported in few familial ALS cases. However, the pathogenicity of S1RE102Q and the beneficial impact of S1R in the ALS context remain to be demonstrated in vivo. To address this, we generated transgenic Drosophila that express human wild-type S1R or S1RE102Q. Expression of mutant S1R in fly neurons induces abnormal eye morphology and locomotor defects in a dose-dependent manner. This was accompanied by abnormal mitochondrial fragmentation, reduced ATP levels and a higher fatigability at the neuromuscular junction during high energy demand. Overexpressing IP3 receptor or glucose transporter mitigates the S1RE102Q-induced eye phenotype, further highlighting the role of calcium and energy metabolism in its toxicity. More importantly, we showed that wild-type S1R rescues locomotor activity and ATP levels of flies expressing the key ALS protein, TDP43. Moreover, overexpressing wild-type S1R enhances resistance of flies to oxidative stress. Therefore, our data provide the first genetic evidence that mutant S1R recapitulates ALS pathology in vivo while increasing S1R confers neuroprotection against TDP43 toxicity.
AI-Mediated Communication: Definition, Research Agenda, and Ethical Considerations
Authors: Hancock Jeffrey T , Naaman Mor , Levy Karen 
Published: November 2019

Abstract
We define Artificial Intelligence-Mediated Communication (AI-MC) as interpersonal communication in which an intelligent agent operates on behalf of a communicator by modifying, augmenting, or generating messages to accomplish communication goals. The recent advent of AI-MC raises new questions about how technology may shape human communication and requires re-evaluation – and potentially expansion – of many of Computer-Mediated Communication’s (CMC) key theories, frameworks, and findings. A research agenda around AI-MC should consider the design of these technologies and the psychological, linguistic, relational, policy and ethical implications of introducing AI into human–human communication. This article aims to articulate such an agenda.
Conceptual Clarity in Clinical Bioethical Analysis
Authors: Parker J Clint 
Published: November 2019

AbstractConceptual clarity is essential when engaging in dialogue to avoid unnecessary disagreement and to promote mutual understanding. In this issue devoted to clinical bioethics, the authors exemplify the virtue of careful conceptual analysis as they explore complex clinical questions regarding the essential nature of medicine, the boundaries of killing and letting die, the meaning of irreversibility in definitions of death, the argument for a right to try experimental medications, the ethical borders in complex medical billing, and the definition and modeling of complex disease states.
Aspect and Thematic Roles
Authors: Ogihara Toshiyuki 
Published: November 2019

AbstractIn this work, I propose a new semantic analysis of the Japanese progressive/resultative morpheme -te iru, which also leads to an improved account of the English progressive and contributes to cross-linguistic theory of aspect. The proposal is based on the modal analysis of the English progressive proposed by Portner (1998) and Ferreira (2016), but it is modified to accommodate the Japanese data. Crucially, the target state (resultative) reading of -te iru is available when the subject entity is a theme/undergoer; this is not controlled by the length of the event being described. To implement this idea, this work develops a formal system in which each thematic role predicate has its own temporal argument, and this time does not necessarily equal the temporal trace of the event in question. Specifically, a theme bears the target state role associated with an event e at a time that immediately follows the temporal trace of e. In addition, to describe and explain the behavior of -te iru, the traditional idea of “inertia worlds” according to which the relevant possible worlds are identical up to the utterance time is modified to allow them to differ in the past as well as in the future. It is noted that this modification is justified for the English progressive as well as for the Japanese -te iru form. This proposal allows us to predict that the behavior of achievements in English and Japanese is alike in simple past sentences and nominalized cases, but differs from each other in sentences containing the aspectual morphemes in question.
A proof-theoretic study of abstract termination principles
Authors: Powell Thomas 
Published: November 2019

Abstract
We carry out a proof-theoretic analysis of the wellfoundedness of recursive path orders in an abstract setting. We outline a general termination principle and extract from its wellfoundedness proof subrecursive bounds on the size of derivation trees that can be defined in Gödel’s system T plus bar recursion. We then carry out a complexity analysis of these terms and demonstrate how this can be applied to bound the derivational height of term rewrite systems.
Status Update on Infection Prevention and Control at Deployed Medical Treatment Facilities
Authors: Barsoumian Alice E , Solberg Steffanie L , Hanhurst Ashley S , Roth Amanda L , Funari Tamara S , Cruz-Fehr Maria Cristina E , Crouch Helen , Florez Christopher , Murray Clinton K 
Published: November 2019

Abstract

Introduction
Infections with multidrug resistant organisms that spread through nosocomial transmission complicate the care of combat casualties. Missions conducted to review infection prevention and control (IPC) practices at deployed medical treatment facilities (MTFs) previously showed gaps in best practices and saw success with targeted interventions. An IPC review has not been conducted since 2012. Recently, an IPC review was requested in response to an outbreak of multidrug resistant organisms at a deployed facility.

Materials and Methods
A Joint Service team conducted onsite IPC reviews of MTFs in the U.S. Central Command area of operations. Self-assessments were completed by MTF personnel in anticipation of the onsite assessment, and feedback was given individually and at monthly IPC working group teleconferences. Goals of the onsite review were to assist MTF teams in conducting assessments, review practices for challenges and successes, provide on the spot education or risk mitigation, and identify common trends requiring system-wide action.

Results
Nine deployed MTFs participated in the onsite assessments, including four Role 3, three Role 2 capable of surgical support, and two Role 1 facilities. Seventy-eight percent of sites had assigned IPC officers although only 43% underwent required predeployment training. Hand hygiene and healthcare associated infection prevention bundles were monitored at 67% and 29% of MTFs, respectively. Several challenges including variability in practices with turnover of deployed teams were noted. Successes highlighted included individual team improvements in healthcare associated infections and mentorship of untrained personnel.

Conclusions
Despite successes, ongoing challenges with optimal deployed IPC were noted. Recommendations for improvement include strengthening IPC culture, accountability, predeployment training, and stateside support for deployed IPC assets. Variability in IPC practices may occur from rotation to rotation, and regular reassessment is required to ensure that successes are sustained through times of turnover.