bluuebunny/crossref_metadata_2025_split huggingface dataset:
PREDICTORS ASSOCIATED WITH ADVERSE DRUG REACTIONS AMONG GERIATRIC PATIENTS IN AN OUTPATIENT CLINIC
Authors: GAYATRI SUJIVE  , BENSAM T MATHEW  , MAMATHA K  , ANURADHA HV  
Published: January 2020

Objective: The process of aging involves an individual’s structural and functional depravity of their organ systems often results in compromised pharmacological principles of the prescribed drugs. Multimorbidity and polypharmacy along with change in pharmacokinetic and pharmacodynamic responses of drugs predispose the elderly to adverse drug reactions (ADRs). The present study was aimed to identify and report the characteristics and incidence of ADRs among geriatrics in an outpatient clinic.
Methods: This was a 6-month prospective hospital-based observational study among patients of either sex aged 60 years and above visiting an outpatient clinic at the study site. The suspected ADRs were categorized according to the Will’s and Brown classification system. Causality of these ADRs was verified by applying the WHO-UMC criteria and the Naranjo’s scale. Severity and preventability of the ADRs were classified using the modified Hartwig and Siegel scale and modified Schumock and Thornton scale, respectively. Multivariate logistic regression was used to determine the risk factors for developing ADRs.
Results: Among the 365 patients monitored, 57 (15%) patients experienced 60 ADRs. Therapeutic classes of drugs frequently associated with ADRs were the drugs used in hypertension (27 [45%]). Patients presenting with amlodipine (9 [15%]) induced pedal edema were observed with the highest frequency of ADRs. Polypharmacy (OR: 1.619, 95% confidence interval: 0.957−2.741, p=0.021) was observed as the influential risk factor for ADRs.
Conclusion: Pharmacist’s services and involvement in geriatric patient’s centered care can be associated with their improved health, quality of life and economic outcomes, a reduction in medicine-related adverse events, and limiting the morbidity and mortality in this age band.
SIDE EFFECTS OF INTRAVENOUS GANCICLOVIR AND COMBINATION OF INTRAVENOUS GANCICLOVIR-ORAL VALGANCICLOVIR IN PEDIATRIC PATIENTS WITH CYTOMEGALOVIRUS INFECTION
Authors: I WAYAN ANDREW HANDISURYA  , NELLY AMALIA RISAN  , DWI PRASETYO  
Published: January 2020

Objective: Intravenous ganciclovir and oral valganciclovir are known to have severe side effects against hematopoiesis and kidney function. This study aims to look for these side effects in pediatric patients with cytomegalovirus (CMV) infection treated with ganciclovir or a combination regimen of both in Hasan Sadikin General Hospital, a tertiary care center in West Java, Indonesia.
Methods: This was a cross-sectional study using medical records and laboratory examination data from pediatric patients with CMV infection who received ganciclovir of 6 mg/kg twice a day, valganciclovir of 16 mg/kg twice a day, or a combination of both in Hasan Sadikin General Hospital from January 2015 to January 2019. Differences before and after therapy were analyzed to look for any side effects in each regimen and duration of therapy.
Results: Out of 115 patients, there were 53 subjects who met the research criteria. Majority of the subjects used a combination regimen (n=29, 55%) for 6 weeks (n=36, 68%). There was no statistically significant difference (p>0.05) in the incidence of anemia, neutropenia, thrombocytopenia, increase in creatinine serum, or increase in blood urea nitrogen for different regimen or duration of therapy.
Conclusion: No side effects were found to be related with therapeutic regimen or duration of therapy in pediatric patients with CMV infection in this study.
BERYLLIUM DRIVEN HEMATOLOGICAL AND SEROLOGICAL ALTERATION; THAT CURED BY CHELATION VIA NARINGENIN IN ALBINO RATS
Authors: ANJANI VERMA  , SAMRAT RAKSHIT  , SATYENDRA KUMAR NIRALA  , MONIKA BHADAURIA  
Published: January 2020

Objective: Environment faces range of pollutions threats due to extensive industrialization and deforestation. In exists scenario metal contamination deadly one among them. Beryllium is 44th most abundant element in earth crust which executes their discharge in society through fossils fuel combustion besides daily routines things as in chips of electric gadgets jewelry, dental crown. The objective of the present investigation was the reduction of beryllium harmful effect through naringenin in female albino rats.
Methods: Female rats were administered by 1mg/kg dose intraperitoneally daily for 28 days alone as well as before/along with three doses (12.5, 25, and 50 mg/kg) of naringenin orally (7 days once in day). Hematological and serological analysis was performed for this clinical research.
Results: Beryllium exposure caused severe alteration in hematological markers evident by a significant diminishment of hemoglobin, red blood corpuscles, mean corpuscular hemoglobin concentration and hematocrit and promoted the level of white blood corpuscles and platelets. Similarly, serological parameters; triglycerides cholesterol and glucose were altered significantly as the response of lipid bilayer peroxidation. All these variables were retrieval near to control ardently by three doses of naringenin.
Conclusion: In short naringenin might be useful as in natural chelation for beryllium body burden.
ANTIDIABETIC POTENTIAL OF PERILLYL ALCOHOL, A MONOTERPENE ON HIGH-FAT DIET LOW-DOSE STREPTOZOTOCIN-INDUCED DIABETES IN EXPERIMENTAL RATS
Authors: TOWSEEF HASSAN  , ELANCHEZHIYAN C  , INSHA NASEER  
Published: January 2020

Objective: The aim of the study was to evaluate the antidiabetic potential of Perillyl alcohol (POH) in high-fat diet (HFD) and low-dose streptozotocin (STZ)-induced diabetic Wistar rats.
Methods: In experimental rats fed with HFD for 4 weeks, diabetes was induced by single intraperitoneal injection of STZ (35 mg/kg body weight [BW]). Three days after STZ induction, the hyperglycemic rats were treated with POH orally at the doses of 50 and 100 mg/kg BW daily for 30 days. Glibenclamide (6 mg/kg BW) was used as reference drug. Blood glucose level, BW, fluid intake, and food intake such as parameters were analyzed throughout the experiment period. Serum and plasma biochemical parameters were also estimated. Assay on insulin resistance was also done. Histological study of the pancreas and liver was also performed.
Results: POH orally at the doses of 50 and 100 mg/kg BW for 30 days significantly (p<0.05) and dose-dependently reduced and normalized blood glucose levels as compared to that of HFD+STZ control group. Serum and plasma parameters were significantly (p<0.05) restored toward the normal levels in POH-treated rats as compared to HFD-STZ control animals. Histological study of liver and pancreas also shows the prominent regeneration in POH and glibenclamide treated rats.
Conclusion: The present study concludes that POH demonstrated promising antidiabetic action in HFD STZ-induced diabetic rats.
SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SUBSTITUTED 1,3,4-OXADIAZOLE DERIVATIVE: DERIVED FROM CIPROFLOXACIN
Authors: ANUJ SINGHAI  , GUPTA M.K. 
Published: January 2020

Objective: The purpose of this research is synthesized and evaluates different derivatives of oxadiazole.
Methods: A novel series of substituted 1,3,4-oxadiazole derivative were synthesized by condensing different amine with 1-cyclopropyl-6-fluoro-7- (piperazin-1-yl)-3-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)quinolin-4(1H)-one (III) in the presence of formaldehyde. The structure of these novel synthesized compounds was characterized on the bases of physicochemical and spectral analysis. The title compounds (IVa-h) were screened for antibacterial activity by disc diffusion method.
Results: Substituted 1,3,4-oxadiazole derivative was synthesized, characterized, and evaluated for antibacterial activity. Compounds IVa, IVd, IVe, IVf, and IV h showed enhance activities then ciprofloxacin against all Gram-positive and Gram-negative organisms. Compound IVe showed the highest activity against Staphylococcus aureus and compound IV showed the highest activity against Escherichia coli.
Conclusion: The present study demonstrates the synthesis and characterization of 1,3,4-oxadiazole derivatives derived from ciprofloxacin. These compounds were evaluated for antibacterial activity against different Gram-positive and Gram-negative organism. In some cases, antibacterial activity is found to be enhanced as compared to standard drug ciprofloxacin.
ONE-POT SYNTHESIS OF 2,4,5-TRIARYLIMIDAZOLES FROM KETO-OXIMES: CHARACTERIZATION AND EVALUATION OF ANTIMICROBIAL ACTIVITY
Authors: KRANTHI KUMAR T  , SREENIVASULU R  
Published: January 2020

Background and Objective: Imidazole scaffold is pervasive in pharmaceuticals and it possesses diverse type of biological activities, especially triarylimidazole derivatives are biologically prominent molecules which inspired the current investigation. The objective of the work is to synthesize 15 novel 2,4,5-triarylimidazole derivatives and evaluate their antimicrobial and antimycobacterial activity against selected bacterial and fungal strains.
Methods: The title compounds 2,4,5-triaryl-imidazole were synthesized from the corresponding aryl aldehydes and keto-oximes through the cyclization to N-hydroxyimidazoles and reduced thermally to the different imidazole derivatives. Agar disc diffusion method is employed for the antimicrobial and antimycobacterial studies.
Results: Fifteen novel 2,4,5-triarylimidazoles were synthesized in adequate yields and characterization of the molecules was done by detailed spectral analysis using advanced analytical support. Results disclosed that all the synthesized compounds were exhibiting antimicrobial properties. Compounds 3h, 3g, 3b, and 3m were stated to possess potent antimicrobial properties in the given bacterial and fungal strains.
Conclusion: The current investigation results support the antimicrobial and antimycobacterial activity of the synthesized 2,4,5-triarylimidazole derivatives. Further, research is necessary to explore the mechanism involved in the antimicrobial activity.
SIMULTANEOUS QUANTIFICATION OF PENTAZOCINE AND NALOXONE BY STABILITY INDICATING REVERSE-PHASE-HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD
Authors: RAMA KUMAR KANDULA  , RAJA SUNDARARAJAN  
Published: January 2020

Objective: The objective of the study was to develope a stability indicating high-performance liquid chromatographic (HPLC) method for simultaneous assay of pentazocine and naloxone in bulk and tablets.
Methods: Pentazocine and naloxone were analyzed on Dionex C18 column using 0.1M K2HPO4 buffer (pH 4.0) and methanol (60:40, v/v) as the mobile phase. The concentration of pentazocine and naloxone was quantified by photodiode array detector set at 248 nm. The method was validated in compliance with ICH rules. Pentazocine and naloxone tablet formulation was subjected to forced degradation such as acid, neutral and alkali hydrolysis, oxidation, photo, and thermal degradation.
Results: The method was linear, with R2=0.9999 in the concentration range 100–300 μg/ml for pentazocine and R2=0.9995 in the concentration range 1–3 μg/ml for naloxone. The level of detection and quantification was 0.097 μg/ml and 0.322 μg/ml for pentazocine and 0.0073 μg/ml and 0.0243 μg/ml for naloxone, respectively. The degraded products are resolved well from pentazocine and naloxone with significantly different retention time values. From validation results, it was proved that the method is selective, precise, robust, and accurate for the estimation of pentazocine and naloxone simultaneously.
Conclusion: The developed stability-indicating HPLC method can be applied for quantitative determination of pentazocine and naloxone in tablets.
Mercosurización de la democracia y los Derecho Humanos: ¿Reaseguro para su vigencia versus regresión con Unasur?
Authors: Morales Antoniazzi Mariela 
Published: January 2020

Con este trabajo se analiza el papel que ha tenido la democracia en las cuestiones jurídicas y políticas en el sr del continente americano, así como el importante papel que juega en materia de derechos humanos. También se hace una conclusión sobre los avances y retrocesos que ha tenido esta región del continente con los tratados firmados en materia de derechos humanos.
Técnica de defensa constitucional ante los formalismos procesales del nuevo sistema general de responsabilidades administrativas para servidores públicos y particulares
Authors: Parada Sánchez David Alejandro 
Published: January 2020

El presente artículo consiste en un análisis del nuevo modelo de Responsabilidad Administrativa de Servidores Públicos y Particulares, derivado de la Ley General de Responsabilidades Administrativas, publicada en dieciocho de julio de dos mil dieciséis, con un enfoque crítico desde la técnica jurídica, para establecer métodos y estrategias para garantizar un ejercicio pleno de una defensa adecuada para el infractor, superando las formalidades procesales.
A través de un método analítico, sistemático, comparativo y deductivo, se establecerán los parámetros de defensa que pueden intentarse, utilizando herramientas normativas como lo es la propia Ley General de Responsabilidades Administrativas, Ley de Amparo y las disposiciones vigentes que rigen el Tribunal Federal de Justicia Administrativa; además, de las jurisprudencias emitidas por el Poder Judicial de la Federación.
Las anteriores normas enlistadas, serán sujetas de un análisis hermenéutico crítico, para definir la procedencia e improcedencia de medios de defensa, así como, la naturaleza de los actos de autoridad, para verificar conclusivamente la validez sustancial de los formalismos procesales, que incluso, podrían tener como consecuencia, una negativa formal de acceso a la justicia.
Visión retrospectiva de la nueva legislación de minería de 1892
Authors: García y Moisés Enrique 
Published: January 2020

Es un texto monográfico que versa sobre la Legislación Minera de 1892, promulgada por le gobierno de Porfirio Díaz. (1876- 1880-1884-1911) la ley tenia como esencia que daba a perpetuidad la Posesión de las minas, lo cual significaba una renuncia tácita por parte del gobierno a la soberanía del suelo en perjuicio de la nación.
Se van haciendo comentario sobre los artículos principales de la legislación, y se da una explicación de las razones que tuvo el gobierno al promulgar dicha ley.
Human Capital of Russian Blue Collars: State, Changes over Time, Factors
Authors: Tihonova Natal'ya , Karavay Anastasiya , Latova Nataliya 
Published: January 2020

The common indicators of human capital of Russian blue collars are typical for the post-Soviet countries, but are highly dispersed by age groups, industries, and types of settlement. Still, these indicators are very low for 75% of Russian blue collars, while the rest have quite high-quality human capital and constitute a talent pool for a tech breakthrough in the national economy. The core drawbacks in the human capital of Russian blue collars from both groups are the lack of professional education in the chosen area and poor inclusion in the system of further learning. These disadvantages are especially evident for blue collars in developed countries.
The quality of human capital of Russian blue collars had gradually improved until the second half of the 2000s. However later, workers were less and less likely to choose a job corresponding to their major, and less often to obtain it. On the other hand, Russians with professional education were less likely to choose blue-collar jobs. The barriers to better quality of human capital were no goals among workers, especially those with blue-collar family traditions, for upskilling, as well as a limited number of jobs promising high qualifications. The poor quality of human capital among most blue collars and their unwillingness to improve their skills are, in these conditions, a rational response to the situation in hand.
Main Stages in the Formation of the Theory of Architecture of the Spanish Renaissance (Based on Treatises of the 16th–17th centuries)
Authors: Sim Nadezhda , Stogova Galina 
Published: January 2020

The Spanish treatises of the 16th — early 17th century on the theory of architecture are reviewed in the context of design evolution, stylistic features of text and visual material, sources of theoretical thought of predecessors that influenced the creative rethinking of architecture, generation of new original ideas and the determination of their place in the evolution of the architectural views of the Renaissance as a whole. The appeal to antiquity as a treasury of humanistic values was typical for the Spanish culture of the 16th century. The Spanish theorists interpreted the focus on the classical tradition in architecture as the embodiment of the ideas of Christian architecture, the source of which was the theoretical legacy of the Italian Renaissance.
The main stages in the formation of the theory of architecture of the Spanish Renaissance are reflected in the works of Diego de Sagredo “The Medidas del Romano” (1526), Juan de Arfe “Measurements for architecture and sculpture” (1564), Fray Lorenzo de san Nicolás “Art use of architecture” (1639). The authors of the treatises tell about the benefits and the need for study, use the construction and artistic experience of antiquity, and provide a didactic overview of the most significant theoretical works of their predecessors with practical tips for building professional skills. In general, the Vitruvian style as the structural basis of classicism was very popular in Spain during Renaissance, and its components serve as the fundamental method of practical use at each stage of the development of architecture.
Comida, Agência e Imitação: Uma Etnografia das Festividades entre Imigrantes Brasileiros na Grande Boston
Authors: Kraieski de Assuncao Viviane 
Published: January 2020

Resumo: A alimentação pode ser entendida como uma importante via de leitura de processos socioculturais. Com esta perspectiva, realizei uma etnografia com imigrantes brasileiros na Grande Boston, buscando compreender as mudanças e continuidades em suas práticas alimentares após a migração. Neste artigo, concentro-me nos relatos etnográficos dos momentos de festividade, que, embora não sejam cotidianos, são recorrentes e marcam as experiências migratórias dos sujeitos da pesquisa. Busco compreender as práticas alimentares destes eventos por meio dos conceitos de agência (Gell, 1998) e mímesis (Taussig, 1993), assumindo, deste modo, o protagonismo da comida nestes momentos. A comida, assim, constitui-se um elemento ativo das festas, que evoca sentimentos e memórias por meio de sua sensorialidade, e contribui para tornar presente e entrar em contato com o outro. Além disso, são utilizados outros aportes teóricos para compreender as variadas formas como a comensalidade está estritamente relacionada aos vínculos sociais entre os sujeitos. Palavras-chaves: Comida. Imigrantes brasileiros. Agência. Mímesis. Festas. Abstract:Food can be understood as an important way of reading sociocultural processes. With this perspective, I conducted an ethnography with Brazilian immigrants in Greater Boston, seeking to understand the changes and continuities in their eating practices after migration. In this article, I focus on the ethnographic accounts of the moments of festivity, which, although not daily, are recurrent and mark the migratory experiences of the research subjects. I seek to understand the eating practices of these events through the concepts of agency (Gell, 1998) and mimesis (Taussig, 1993), thus assuming the role of food in these moments. Food, thus, is an active element of the holidays, which evokes feelings and memories through its sensoriality, and contributes to make present and be in contact with the other. In addition, other theoretical contributions are used to understand the varied ways in which commensality is strictly related to social bonds between the subjects. Keywords: Food. Brazilian immigrants. Agency. Mimesis. Parties.
A Comida e o Comer durante o Jubileu de São Miguel e Almas no Cemitério do Peixe
Authors: Tavares Thiago Rodrigues , Castro Vanessa Gomes de 
Published: January 2020

Resumo: O objetivo desse trabalho é descrever e analisar aspectos relacionados à comida e ao ato de comer durante o Jubileu de São Miguel e Almas no Cemitério do Peixe (MG), notadamente, aspectos culturais, sociais, políticos e econômicos. Para tanto, utilizam-se métodos e caminhos propostos pela Antropologia, tais como observação participante, entrevistas abertas e semiestruturadas, escrita etnográfica, além de revisão bibliográfica, entre os anos de 2012 a 2019. Conclui-se que, no ambiente observado, através do ato de comer e compartilhar alimentos, são instauradas relações de sociabilidade e solidariedade, as quais reforçam a coesão social, a memória, a identidade e o patrimônio cultural do grupo. Destacam-se relações harmoniosas e afetuosas em torno do ato de comer, bem como a criação de vínculos, os quais geram obrigações sociais.Palavras-chave: Comida. Comer. Socialização. Festas. Cemitério do Peixe. Abstract: This paper's objective is to describe and reflect upon the food and the act of eating during the Jubilee of São Miguel e Almas in Cemitério do Peixe (MG), notably cultural, social, political and economical aspects. To that end, methods and paths proposed by Anthropology are used, such as participant observation, open and semi-structured interviews, ethnographic writing and bibliographic review, between 2012 and 2019. It concludes that, in the observed environment, through the act of eating and sharing food, sociability and solidarity relationships are established, reinforcing social cohesion, the group's memory, identity and cultural patrimony. Harmonic and fondness relationships stand out around the act of eating, such as the creation of bonds, which generate social obligations.Keywords: Food. Eating. Socialization. Religious Festivals. Cemitério do Peixe
Pelatihan Teknik Pengumpulan Data Geografis Berbantuan Peta dan Citra pada Siswa SMA
Authors: Safitri Febriani , Romarak Alfasis , Tumober Renny Thereesje 
Published: January 2020

Pembelajaran penelitian-penelitian geografi merupakan salah satu goal pendidikan dalam Kurikulum 2013. Kompetensi yang harus dicapai siswa dalam materi ini adalah memahami langkah-langkah penelitian geografi, termasuk teknik-teknik pengumpulan data geografis. Karena itu, diperlukan pelatihan bagi siswa yang bertujuan untuk meningkatkan kemampuan siswa dalam memahami teknik pengumpulan data geografis. Kegiatan pelatihan menggunakan media peta dan citra. Luaran utama yang diharapkan dalam pengabdian ini adalah jurnal atau publikasi ilmiah. Mitra kegiatan pengabdian ini adalah siswa SMA YPK Diaspora Kotaraja dengan lokasi kegiatan di sekolah dan Kawasan Pantai Base-G, Kota Jayapura. Metode pelaksanaan kegiatan pengabdian dalam bentuk pelatihan. Kegiatan pelatihan dilaksanakan dalam bentuk pemberian materi, praktek interpretasi peta dan citra. Hasil kegiatan pengabdian menunjukkan bahwa siswa peserta pelatihan telah mampu mengumpulkan data geografis melalui interpretasi peta dan citra.