bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemogenetic activation of mesoaccumbal Gamma-Aminobutyric Acid projections selectively tunes responses to predictive cues when reward value is abruptly decreased
Authors: Wakabayashi Ken T. , Feja Malte , Leigh Martin P.K. , Baindur Ajay N. , Suarez Mauricio , Meyer Paul J. , Bass Caroline E. 
Published: March 2020

ABSTRACTBackgroundMesolimbic circuits regulate the attribution of motivational significance to incentive cues that predict reward, yet this network also plays a key role in adapting reward-seeking behavior when the contingencies linked to a cue unexpectedly change. Here we asked whether mesoaccumbal gamma-aminobutyric acid (GABA) projections enhance adaptive responding to incentive cues of abruptly altered reward value, and whether these effects were distinct from global activation of all ventral tegmental area (VTA) GABA circuits.MethodsWe used a viral targeting system to chemogenetically activate mesoaccumbal GABA projections in male rats during a novel cue-dependent operant Value Shifting (VS) task, in which the volume of a sucrose reward associated with a predictive cue is suddenly altered, from the beginning and throughout the session. We compared the results with global activation of VTA GABA neurons, which will activate local inhibitory circuits and long loop projections.ResultsWe found that activation of mesoaccumbal GABA projections decreases responding to incentive cues associated with smaller-than-expected rewards. This tuning of behavioral responses was specific to cues associated with smaller-than-expected rewards, but did not impact measures related to consuming the reward. In marked contrast, activating all VTA(GABA)neurons resulted in a uniform decrease in responding to incentive cues irrespective of changes in the size of the reward.ConclusionsTargeted activation of mesoaccumbal GABA neurons facilitate adaptation in reward-seeking behaviors. This suggests that these projections may play a very specific role in associative learning processes.
TranslocatingMycobacterium ulcerans: an experimental model
Authors: Hammoudi N , Fellag M , Militello M , Bouam A , Drancourt M 
Published: March 2020

ABSTRACTMycobacterium ulceransis a non-tuberculous environmental mycobacterium responsible for extensive cutaneous and subcutaneous ulcers in mammals, named Buruli ulcer in patients.M. ulceranshas been seldom detected in the feces of mammals but not in patients, nevertheless the detection and isolation ofM. ulceransin animal feces does not feet with the current epidemiological schemes for the disease. Here using an experimental model in which rats were fed with 109colony-forming units ofM. ulcerans, we detectedM. ulceransin feces of challenged rats for two weeks and along their digestive tract for 10 days.M. ulceranswas further detected in the lymphatic system including cervical and axillary lymph nodes and the spleen, but not in any other tissue including the healthy and breached skin, 10 days post-challenge. These observations indicate that in some herbivorous mammals,M. ulceranscontamination by the digestive route may precede translocation and limited infection of the lymphatic tissues without systemic infection. These herbivorous mammals may be sources ofM. ulceransfor exposed populations but are unlikely reservoirs for the pathogen.
Cathepsin K maintains the number of lymphocytesin vivo
Authors: Hausinger Renate , Hackl Marianne , Jardon-Alvarez Ana , Kehr Miriam , Marquez Sandra Romero , Hettler Franziska , Kehr Christian , Grziwok Sandra , Schreck Christina , Peschel Christian , Istvanffy Rouzanna , Oostendorp Robert A.J. 
Published: March 2020

AbstractIn this study, we investigated the influence of the loss of Cathepsin K (Ctsk)gene on the hematopoietic systemin vitroandin vivo. We found that cultures with Lineage-SCA1+KIT+(LSK) cells onCtskdeficient stromal cells display reduced colony formation and proliferation, with increased differentiation, giving rise to repopulating cells with reduced ability to repopulate the donor LSK and T cell compartments in the bone marrow. Subsequentin vivoexperiments showed impairment of lymphocyte numbers, but, gross effects on early hematopoiesis or myelopoiesis were not found. Most consistently inin vivoexperimental settings, we found a significant reduction of (donor) T cell numbers in the bone marrow. Lymphocyte deregulation is also found in transplantation experiments, which revealed thatCtskis required for optimal regeneration not only of T cells, but also of B cells. Interestingly, cell non-autonomousCtskregulates both B- and T cell numbers, but T cell numbers in the bone marrow require an additional autonomousCtsk-dependent process. Thus, we show thatCtskis required for the maintenance of hematopoietic stem cellsin vitro, butin vivo, Ctskdeficiency most strongly affects lymphocyte homeostasis, particularly of T cells in the bone marrow.
C-Eci: A Cubic-Eci Combined Clearing Method For 3D Follicular Content Analysis In The Fish Ovary
Authors: Lesage Manon , Thomas Manon , Bugeon Jérôme , Branthonne Adèle , Gay Stéphanie , Cardona Emilie , Bobe Julien , Thermes Violette 
Published: March 2020

ABSTRACTDeciphering mechanisms of oocyte development in female fishes still remains challenging and a comprehensive overview of this process at the level of the organ is still needed. The recent development optical tissue clearing methods have tremendously boosted the 3D imaging of large size biological samples that are naturally opaque. However, no attempt of clearing on fish ovary that accumulates extremely high concentration of lipids within oocytes has been reported to date. To face with this ovarian-specific challenge, we combined two existing clearing methods, the non-toxic solvent-based Eci method for efficient clearing and the CUBIC method to enhance lipid removal and reduce non-specific staining. The methyl green fluorescent dye was used to stain nuclei and delineate follicles. Using this procedure (named C-Eci), ovaries of both medaka and trout could be imaged in 3D and all follicles analyzed. To our knowledge this is the first procedure elaborated for clearing and imaging fish ovary in 3D. The C-Eci methods thus provides an interesting tool for getting precise quantitative data on follicular content in fish ovary and promises to be useful for further morphological studies.SummaryA modified ethyl-cinnamate-based clearing method allows solving fish ovary-specific challenges for 3D imaging, including high lipid-contents, and analyzing the ovarian follicular content in medaka and trout.
The impact of external pressures (gaiatsu) and internal pressures (naiatsu) on Japan's accounting reforms since the late 1990s
Authors: Tsunogaya Noriyuki , Patel Chris 
Published: March 2020

PurposeThe paper extends the literature by examining the impact of politics, conflicts and compromises resulting from external pressures (gaiatsu, 外圧) and internal pressures (naiatsu, 内圧) on the convergence and globalization of accounting and accountability in Japan.Design/methodology/approachUsing Japan as a case study, it is examined how and why the stimulus for significant accounting reforms arises, how the government manages and reacts to the powerful forces ofgaiatsuand how it balancesnaiatsuamong key stakeholders.FindingsThe ongoing changes in accounting regulations in Japan are neither the result of an unmediated response togaiatsunor the outcome ofnaiatsu. Rather, Japanese accounting changes are the consequence of complex external interactions and internal compromises. Specifically, Japan demonstrates a repetitive pattern of conflict management, which alters the domestic power balance based onnaiatsu, and forces the Japanese government to make compromises to policy changes initiated bygaiatsu.Research limitations/implicationsThe findings have implications for the development of accounting and accountability, the globalized business world and international accounting research because they challenge claims made by global standards setters that international standards such as International Financial Reporting Standards are superior, are built on so-called “best practices” and are relevant to all countries.Originality/valueInvoking the concepts ofgaiatsuandnaiatsuis a critical approach to understanding Japan's convergence toward economic liberalism and Anglo-American models of accounting and accountability.
The study of online reviews and its relationship to online purchase intention for electronic products among the millennials in Malaysia
Authors: Cheong Jian Wei , Muthaly Siva , Kuppusamy Mudiarasan , Han Cheng 
Published: March 2020

PurposeThe purpose of this research is to examine the type of online reviews (review timeliness, review quantity, and review valence) and its relationship toward online purchase intention for electronic products among millennials in Malaysia.Design/methodology/approchThe quantitative approach and simple random sampling methodology were used in this research. Data were gathered through a survey instrument, and the partial least squares structural equation modeling (PLS-SEM) technique was subsequently applied to 215 responses. The model explained 36.3 percent variation of the major constructs in relation to online purchase intention of electronic products amongst Malaysian millennials.FindingsReview timeliness is the most influential online reviews element towards Malaysian millennials' online purchase intention for electronic products.Originality/valueThis research project has provided the researcher and marketers with more clarity into the area of online purchase intention for electronic products, which is a volatile and dynamic area with continuous uncertainty.
Enhancing consumer engagement in e-commerce live streaming via relational bonds
Authors: Hu Mingyao , Chaudhry Sohail S. 
Published: March 2020

PurposeEnhancing consumer engagement in e-commerce live streaming is critical for e-commerce operators to build relationships and create consumer loyalty. Using the stimulus–organism–response model and theories from relationship marketing, the authors develop and test an integrative conceptual framework that combines various relational bonds, affective commitment, and consumer engagement.Design/methodology/approachUsing 327 valid responses from consumers of Taobao Live, the authors employed the software Mplus7.0 to evaluate the measurement model and the structural model.FindingsThe results empirically demonstrate that social and structural bonds positively affect consumer engagement directly and indirectly via affective commitment, while financial bonds have only an indirect effect via affective commitment on consumer engagement.Practical implicationsThe findings provide useful insights for e-commerce operators, who should invest in establishing relational bonds and stimulating affective commitment to improve consumer engagement.Originality/valueThis study adds to e-commerce research by being one of the first empirical studies on e-commerce live streaming, extends the marketing literature by integrating different relational bonds as antecedents of consumer engagement from the relational perspective, and enriches the affective commitment literature by distinguishing commitment to the online marketplace from commitment to the broadcaster.
Connecting supplier–supplier relationships to achieve supply chain performance of restaurant companies
Authors: Ku Edward C.S. , Hsu Shun-Fa , Wu Wu-Chung 
Published: March 2020

PurposeThe goal of this study is to investigate how the development efficiency of restaurant companies' products of their suppliers, supplier–supplier connection, design quality and adaptation affect the supply chain performance (SCP) of restaurant companies.Design/methodology/approachWe use the stratified random-sampling method for this study. We mailed the research questionnaire to the managers in the cases where they could be identified; a total of 1,063 questionnaires were sent by mail and a useable response of 156 fully completed questionnaires was received.FindingsWhen the supplier has good development efficiency of restaurant companies' products, they can comply with the requirements of the budget project, and then, finally adapt to the restaurant companies to strengthen mutual relations of coexistence; suppliers with a good connection can make restaurant companies willing to go along with them.Research limitations/implicationsThe limitation of this study was that the different types of suppliers were not compared, and some restaurants without scaled operations may have different effects on the result.Practical implicationsThe supplier–supplier connection is established when the suppliers or companies have generated important decisions. The suppliers will cope with the restaurant companies to make the delivery procedure more unhindered and invest in highly specialized equipment in the relationship and finally, improve the SCP.Originality/valueThis study focuses on the restaurant companies in partnership: how to cooperate with the suppliers to make good supply efficiency, and thus enhance the SCP of the restaurant companies. Overall, the results of the study have provided reliable instruments for operationalizing the key effect constructs in the analysis of operational performance.
Joining-the-dots: caring for patients in advanced age
Authors: Miskelly Philippa , Kerse Ngaire , Wiles Janine 
Published: March 2020

Purpose
Managing patients in advanced age is complex, especially when it comes to multi-morbidities and polypharmacy. The purpose of this qualitative study is to investigate challenges, opportunities and potential solutions from a primary healthcare provider perspective.

Design/methodology/approach
Fifty-seven participants joined in group discussions on challenges and opportunities of working with advanced age. Participants included general practitioners (GPs), practice nurses, students and administration staff working in ten general practices. A thematic analysis was developed, supported by NVivo software.

Findings
Poor lines of communication and fragmentation of services between differing levels of health care services available for older people were highlighted. This has implications for quality of care and equity of services. Participants also reported challenges in treatment and funding regimes.

Research limitations/implications
The small sample size and regional nature of the study, along with the semi-structured nature of the group discussions and rigorous thematic analysis, indicate that this qualitative data is transferable, dependable, confirmable and credible. Comparing the views of tertiary and community services would be useful.

Practical implications
A range of potential strategies and solutions to the current fragmented services was offered by GPs. For example, adequately funded and staffed community-based health hubs; IT platforms enabling timely flow of patient information between primary and tertiary health providers and creation of medical, nursing and allied health roles aimed at improving synergy between GP and tertiary services.

Originality/value
Obtaining the perspectives of general practice highlights the challenges and complexities of caring for those in advanced age brings. These insights have not been previously been explored in-depth within this setting in New Zealand.
Conceptualising online fashion brand recognition: scale development and validation
Authors: Rahman Muhammad Sabbir , Hossain Md Afnan , Rushan Md Rifayat Islam , Hoque Mohammad Tayeenul , Hassan Hasliza 
Published: March 2020

Purpose
This study aims to develop and validate a scale for measuring online fashion brand recognition (OFBR).

Design/methodology/approach
Given the existing literature on brand, multiple stages of studies were conducted as a part of the scale development process. The OFBR scale was validated by a step-by-step process following the scale validation methodology suggested in the specialised literature.

Findings
The results demonstrate the 25 items of five unique factors that form the OFBR construct and confirm the strong validity of the construct. This finding suggests that the five-dimensional approach (online brand familiarity, online visual simplicity, online aesthetic attraction, online brand emotion and online social reputation) plays important role to form OFBR.

Practical implications
A valid and reliable OFBR scale provides a foundation for broadening the understanding on the important constructs that form OFBR, which is essential for online fashion retailing. Knowledge of the crucial antecedents that influence consumers towards online fashion products can enhance marketers’ capability to position their brands towards their target markets.

Originality/value
The relevance of this study lies in validating the scale for measuring OFBR for the first time in the literature on online fashion brand.
Predictions, Pollification, and Pol Profs: the ‘Corbyn Problem’ beyond Corbyn
Authors: Allen Peter , Moon David S. 
Published: March 2020

AbstractIt has been noted that UK political punditry has a ‘Corbyn problem’: an underlying hostility to the Corbyn project and its supporters. As the Corbyn era draws to a close, we take stock and argue that the Corbyn problem was never fully ‘about’ Corbyn. Instead, it was the outward manifestation of a conjunction of tendencies present in contemporary UK politics: the prominence of a relatively small group of ‘intensely involved’ individuals driving dominant political discourse; the inability of traditional purveyors of broadcast media coverage to adapt to contemporary political currents and an unwillingness to self‐reflect on possible biases in their approach; and the ‘pollification’ of election campaign coverage, aided by mainstream political scientists stereotyped in the figure of the ‘Pol Prof’. Combined, these tendencies are hostile to left‐wing political actors and movements. They will not disappear with Corbyn and may even intensify as their structural underpinnings strengthen further.
Atypical endometrial polyps and the incidence of endometrial cancer: a retrospective cohort study
Authors: Jacobs ISM , Tibosch RMG , Geomini PMAJ , Coppus SFPJ , Bongers MY , van Hanegem N 
Published: March 2020

ObjectiveThe aim of this study was to evaluate the incidence of endometrial carcinoma, proven after hysterectomy, in patients diagnosed with atypical endometrial hyperplasia confined to a polyp. A secondary aim was to establish factors associated with (pre‐)malignant alterations in a polyp.DesignA retrospective cohort study.SettingMaastricht University Medical Centre (MUMC+) and Máxima Medical Centre in Eindhoven/Veldhoven (Máxima MC).PopulationWomen who underwent a hysteroscopic polyp resection between 2008 and 2016.MethodsPatient characteristics and histopathology results of the polyp and, in the case of a hysterectomy, uterus were collected from patients’ charts.ResultsA total of 1445 complete hysteroscopic polyp resections were included. Of those, 1390 polyps showed benign histopathology results, 39 polyps contained atypical hyperplasia and 16 polyps contained endometrial carcinoma. A hysterectomy was performed in 35 women who were diagnosed with atypical hyperplasia confined to a polyp after hysteroscopic polyp resection. Histopathological assessment showed no additional (pre‐)malignant changes of the endometrium in 12 women (30.8%), atypical hyperplasia in 11 women (28.2%) and endometrial carcinoma in 12 women (30.8%). None of the prognostic factors under consideration were significantly associated with (pre‐)malignant changes in a polyp.ConclusionThe incidence of endometrial carcinoma in the surrounding endometrium after complete resection of a polyp with atypical hyperplasia is 30.8% in this study. This supports the current advice to perform a hysterectomy and bilateral salpingo‐oophorectomy. No prognostic factor for (pre‐)malignant changes in a polyp was established.Tweetable abstractThe incidence of endometrial carcinoma after complete resection of a polyp with atypical hyperplasia is high.
Long‐term trend in socioeconomic inequalities and geographic variation in the utilization of antenatal care service in India between 1998 and 2015
Authors: Lee Hwa‐Young , Oh Juhwan , Kim Rockli , Subramanian S.V. 
Published: March 2020

AbstractObjectiveTo investigate the temporal trend of socioeconomic and rural‐urban disparities and geographical variation in the utilization of antenatal care (ANC) services in India before and throughout the Millennium Development Goals era.Data Sources/Study SettingFor this temporal analysis, secondary data from the Indian National Family Health Surveys between 1998 and 2015 (Waves 2, 3, and 4) were used.Study DesignWe analyzed the trend in inequality for at least one and four ANC visits to a health care professional (ANC1+ and ANC4+, respectively) by education, wealth, and residence type. Multilevel logistic regression models were used to assess the temporal trend and the relative contribution of communities and states to the overall variation in ANC1+ and ANC4+.Data Collection/Extraction MethodsData on utilization of ANC services for the last birth of women aged 15‐49 years during the three or five years preceding the survey (depending on the survey year) were used.Principal FindingsEducational and wealth inequality in ANC1+ and ANC4+ worsened between 1998 and 2005 and improved between 2005 and 2015 (for ANC4+, OR [95% CI] = 0.22 [0.19‐0.25] in Wave 2; OR [95% CI] = 0.19 [0.17‐0.22] in Wave 3; and OR [95% CI] = 0.38 [0.36‐0.40] in Wave 4 for the poorest). Rural‐urban inequality showed a consistent decline (for ANC4+, OR [95% CI] = 0.59 [0.54‐0.64] in Wave 2; OR [95% CI] = 0.63 [0.59‐0.68] in Wave 3; and OR [95% CI] = 0.82 [0.79‐0.85] in Wave 4 for rural area). The relative contribution of the community to the total geographic variation in the utilization of ANC services increased more than four times during the study period.ConclusionsThe use of ANC services remains disproportionately lower among women with low socioeconomic status. Efforts to directly target these women are necessary to tackle inequality in ANC utilization in India.
Quantifying and Ranking Quality for Acquired Recordings on Digital Video Recorders
Authors: Bruehs Walter E. , Stout Dorothy 
Published: March 2020

AbstractAs the closed‐circuit television (CCTV) security industry transitioned from analog media to digital video recorders (DVRs) with digital storage, the law enforcement community struggled with the means with which to collect the recordings. New guidelines needed to be established to determine the collection method which would be efficient as well as provide the best quality evidence from live DVRs. A test design was developed to measure, quantify, and rank the quality of acquisition methods used on live systems from DVRs typically used in digital CCTV systems. The purpose was to determine guidelines for acquiring the best quality video for investigative purposes. A test pattern which provided multiple quantifiable metrics for comparison between the methods of acquisition was used. The methods of acquisition included direct data download of the proprietary file and open file format as well as recording the video playback from the DVR via the available display monitor connections including the composite video, Video Graphics Array (VGA), and high‐definition multimedia interface (HDMI). While some acquisition methods may provide the best quality evidence, other methods of acquisition are not to be discounted depending on the situation and need for efficiency. As an investigator that needs to retrieve video evidence from live digital CCTV systems, the proprietary file format, overall, provides the best quality evidence. However, depending on the circumstance and as recording technology continues to evolve, options other than the proprietary file format may provide quality that is equal to or greater than the proprietary file format.