bluuebunny/crossref_metadata_2025_split huggingface dataset:
Misplacement of the tunnel hemodialysis catheter through the left jugular vein to the azygos vein
Authors: Cao Dan , Shen Zhaonan , Gui Qiaoqiao , He Yun 
Published: April 2020

Abstract

Rationale:
The percutaneous catheterization of central veins is widely applied in patients with end-stage renal diseases as a permanent vascular access. To our knowledge, inadvertent placement of a hemodialysis catheter into the azygos vein through the left internal jugular vein is not described.

Patient concerns:
A 72-year-old female patient was admitted to the hospital for replacement of another new tunneled hemodialysis catheter due to poor flow in the left internal jugular vein tunneled catheter during hemodialysis.

Diagnosis:
The catheter tip was incorrectly positioned into the azygos vein as confirmed by conventional anteroposterior and lateral chest radiographs.

Interventions:
The catheter was removed and replaced under Digital Subtraction Angiography.

Outcomes:
The catheter tip was finally placed in the proper position.

Lessions:
The insertion of central vein catheterization is not always in suitable position especially through left jugular vein in hemodialysis patients. DSA technology should be performed to confirm the correct position of the tip and to ensure good blood flow.
Early stage Acute B lymphocytic leukemia presenting with symptoms of ankylosing spondylitis (AS)
Authors: Liu Wei , Chen Guangfeng , Xu Bing , Sun Suping , Tian Jingzhen , Zhang Yingying 
Published: April 2020

Abstract

Rationale:
Acute lymphoblastic leukemia (ALL) has acute and severe onset characterized by fever, moderate to severe anemia, bone and joint pain, and sternal tenderness. It is easy to be misdiagnosed as rheumatic disease when joint pain is the first symptom.

Patient concerns:
A male Han, 18 years of age was admitted on July 15th, 2016 for multi-joint swelling and pain with intermittent fever for half a year which had aggravated in the last 10 days.

Diagnosis:
Based on symptoms, imaging, family history, and blood tests, he was first diagnosed with ankylosing spondylitis, but he was refractory to treatment. Bone marrow biopsy then revealed acute B-lymphoblastic leukemia (possibility Pro-B-ALL).

Interventions:
The patient was transferred to the hematology department on July 23rd, 2016 for chemotherapy.

Outcomes:
No joint pain occurred during follow-up, which ended on November 4th, 2018.

Lessons:
ALL may present with symptoms suggestive of rheumatic diseases like ankylosing spondylitis. Physicians should be aware of this possibility, especially in young patients.
Face Lift Using Dual Deep Tissue Support
Authors: Yang Doo Byung , Yang Jung Hak , Kim So Young 
Published: April 2020

Background:
Utilizing the concept of Barton's high superficial musculo-aponeurotic system (SMAS) technique, the authors performed the more extensive skin-attached SMAS/platysma flap elevation and the ‘dual deep tissue support’ technique involving multiple plications of the parotid-masseteric fascia, repositioning of the SMAS, and platysma muscle. Our aim was to demonstrate a specific surgical procedure for face and neck lift and offer its pitfalls and outcomes.

Methods:
This study included 83 patients aged between 54 and 73 years. The pre- and 10-month postoperative photographs of all patients were used to assess the extent of the nasolabial folds, the labiomental fold, and the cervical band (platysma band). Each patient's subjective aesthetic satisfaction was also evaluated.

Results:
At 3 and 6 months postoperatively, 94% (n = 3) of patients achieved “minimal” and “mild” nasolabial folds. Most patients (89.1%, n = 74) were satisfied with their outcomes. Two minor hematomas (2.4%) occurred locally over the temporal or retro-auricular area. No incidence of skin flap necrosis or permanent facial nerve injury was observed.

Conclusions:
Our extensive skin-attached SMAS/platysma flap elevation with dual deep tissue support, both by multiple parotic masseteric plication and SMAS/platysma repositioning, provided not only the definite lifting effect in the immediate postoperative period, but also resulted in long-lasting lifting outcomes without remission.

Level of evidence:
IV.
Closure of the Nasal and Buccal Layers in V-Y Pushback Palatoplasty: Use of a Spring Carrier
Authors: Hwang Kun , Lee Se Il 
Published: April 2020

Abstract
The aim of this paper is to re-introduce Kilner and Calnan's technique of closing the nasal and buccal layers in V-Y pushback palatoplasty by using the spring carrier on the mouth gag.
After flap elevation and dissection, the first suture is inserted through the nasal layer of the mucosa at the level of the posterior border of the hard palate. This 3–0 stitch is left untied until later. The nasal layer is approximated by inserting a series of 4–0 sutures so that the knots can be tied on the mucosal surface inside the nose. All sutures are inserted before any are tied. The sutures are inserted consecutively, moving from the hard palate region toward the uvula. The sutures may be held on the spring suture carrier attached to the mouth gag; they should be covered by a damp swab. When all sutures have been inserted, they are then tied firmly with three knots, working from behind to forward, and cut short by the surgeon. The buccal layer is closed starting from the uvula and moving toward the hard palate. A series of interrupted mattress sutures are inserted to unite the mucosa and the velar muscles. The inserted sutures are tied before the next stitch. They may be cut by the assistant, leaving 3 to 4 mm beyond the knot.
In this technique, the untied sutures could be arranged well on the spring suture carrier attached to the mouth gag. When covered by a damp swab, the catgut sutures did not dry up.
Correlation Between Lacrimal Syringing Test and Dacryoscintigraphy in Patients With Epiphora
Authors: Kim Seungheon , Yang Sungwon , Park Jinhwan , Lee Hwa , Baek Sehyun 
Published: April 2020

Abstract
The purpose of this study was to evaluate the correlation between the lacrimal syringing test (LST) and dacryoscintigraphy (DSG) in patients with epiphora. The authors retrospectively reviewed the clinical records of patients who underwent both LST and DSG from March 2016 to February 2018. From this, 636 eyes of 336 patients with a mean age of 61.20 ± 11.93 years (range, 22–86 years) were included. The concordance rate between LST and DSG was 43.7% (278 eyes). The sensitivity of DSG was 68.78%, and specificity was 30.99%. Factors of age and sex were analyzed in terms of concordance. The authors categorized age into 2 groups of younger and older than 65 years. Only sex was found to affect the results, with a much higher concordance rate in the female group than the male group. The lack of correlation between the tests indicates that the LST and DSG methods are complementary to each other. There is no single reliable method for testing patency of the lacrimal drainage system. Therefore, physicians should refer to these tests as complementary in a clinic setting.
Analysis of Prognostic Factors for the Indirect Traumatic Optic Neuropathy Underwent Endoscopic Transnasal Optic Canal Decompression
Authors: Lin Jingquan , Hu Wanglu , Wu Qun , Yi Jianhua , Liu Zhihai , Zhou Guangju , Ma Feiqiang , Zhang Jianmin , Yan Wei 
Published: April 2020

Objective:This study aimed to investigate the clinical outcomes of endoscopic transnasal optic canal decompression (ETOCD) for patients with indirect traumatic optic neuropathy (TON) and identify the relevant prognostic factors.Methods:Seventy-two indirect TON patients who underwent ETOCD surgery from August 2017 to May 2019 were analyzed retrospectively. The pairedt-test was used to compare the visual acuity (VA) before and after ETOCD, and multiple linear regression analysis was used to distinguish the potential prognostic factors.Results:Among the patients analyzed, postoperative VA (−2.87 ± 0.19) was significantly higher than the preoperative VA (−3.92 ± 0.13) (P < 0.05). Multiple linear regression analysis models showed that poor initial VA and longer time to surgery were independent risk factors for VA prognosis (P < 0.05), but surgical time alone was significantly associated with the improvement degree of visual acuity (IDVA) (P < 0.05). Optic canal fracture, orbital fracture, and hemorrhage within the ethmoid and/or sphenoid sinus were not significantly correlated with IDVA and VA prognosis (P > 0.05).Conclusions:ETOCD surgery could salvage VA impairment in patients with indirect TON. A better initial VA indicates better final VA outcomes after surgery. Additionally, shorter time to surgery implies better VA prognosis and higher IDVA.
Association of Surgical Resident Wellness With Medical Errors and Patient Outcomes
Authors: Hewitt Daniel Brock , Ellis Ryan J. , Chung Jeanette W. , Cheung Elaine O. , Moskowitz Judith T. , Huang Reiping , Merkow Ryan P. , Yang Anthony D. , Hu Yue-Yung , Cohen Mark E. , Ko Clifford Y. , Hoyt David B. , Bilimoria Karl Y. 
Published: April 2020

Objectives:
The aims of this study were to: (1) measure the prevalence of self-reported medical error among general surgery trainees, (2) assess the association between general surgery resident wellness (ie, burnout and poor psychiatric well-being) and self-reported medical error, and (3) examine the association between program-level wellness and objectively measured patient outcomes.

Summary of Background Data:
Poor wellness is prevalent among surgical trainees but the impact on medical error and objective patient outcomes (eg, morbidity or mortality) is unclear as existing studies are limited to physician and patient self-report of events and errors, small cohorts, or examine few outcomes.

Methods:
A cross-sectional survey was administered immediately following the January 2017 American Board of Surgery In-training Examination to clinically active general surgery residents to assess resident wellness and self-reported error. Postoperative patient outcomes were ascertained using a validated national clinical data registry. Associations were examined using multivariable logistic regression models.

Results:
Over a 6-month period, 22.5% of residents reported committing a near miss medical error, and 6.9% reported committing a harmful medical error. Residents were more likely to report a harmful medical error if they reported frequent burnout symptoms [odds ratio 2.71 (95% confidence interval 2.16–3.41)] or poor psychiatric well-being [odds ratio 2.36 (95% confidence interval 1.92–2.90)]. However, there were no significant associations between program-level resident wellness and any of the independently, objectively measured postoperative American College of Surgeons National Surgical Quality improvement Program outcomes examined.

Conclusions:
Although surgical residents with poor wellness were more likely to self-report a harmful medical error, there was not a higher rate of objectively reported outcomes for surgical patients treated at hospitals with higher rates of burnout or poor psychiatric well-being.
Interferon-α2b treatment for COVID-19
Authors: Zhou Qiong , Chen Virginia , Shannon Casey P. , Wei Xiao-Shan , Xiang Xuan , Wang Xu , Wang Zi-Hao , Tebbutt Scott J. , Kollmann Tobias R. , Fish Eleanor N. 
Published: April 2020

AbstractBackgroundThe global pandemic of COVID-19 cases caused by infection with SARS-CoV-2 is ongoing, with no approved antiviral intervention. We describe here the effects of treatment with interferon-α2b in a cohort of confirmed COVID-19 cases in Wuhan, China.MethodsIn this retrospective study, 77 adults hospitalized with confirmed COVID-19 were treated with either nebulized IFN-α2b (5mU b.i.d.), arbidol (200mg t.i.d.) or a combination of IFN-α2b plus arbidol. Serial SARS-CoV-2 testing along with hematological measurements, including cell counts and blood biochemistry, serum cytokine levels, temperature and blood oxygen saturation levels were recorded for each patient during their hospital stay.ResultsTreatment with IFN-α2b with or without arbidol significantly reduced the duration of detectable virus in the upper respiratory tract and in parallel reduced duration of elevated blood levels for the inflammatory markers IL-6 and CRP.ConclusionThese findings suggest that IFN-α2b should be further investigated as a therapy in COVID-19 cases.
Open and laparoscopic approaches are associated with comparable 90-day morbidity and mortality following ERAS protocol
Authors: Vasavada Bhavin B. , Patel Hardik 
Published: April 2020

ABSTRACTIntroductionThe aim of this study is to compare 90-day mortality and morbidity between open and laparoscopic surgeries performed in one centre since the introduction of ERAS protocols.Material and MethodsAll gastrointestinal surgeries performed between April 2016 and March 2019 at our institution after the introduction of ERAS protocols have been analysed for morbidity and mortality. The analysis was performed in a retrospective manner using data from our prospectively maintained database.ResultsWe performed 245 gastrointestinal and hepatobiliary surgeries between April 2016 and March 2019. The mean age of patients was 50.96 years. 135 were open surgeries and 110 were laparoscopic surgeries. The mean ASA score was 2.4, the mean operative time was 111 minutes and the mean CDC grade of surgery was 2.56. 40 were emergency surgeries and 205 were elective surgeries. Overall the 90-day mortality rate was 8.5% and the morbidity rate was around 9.79%. On univariate analysis morbidity was associated with a higher CDC grade of surgeries, a higher ASA grade, longer operating time, the use of more blood products, a longer hospital stay and open surgeries. HPB surgeries and luminal surgeries (non hpb gastrointestinal surgeries) were associated with 90 day post operative morbidity. On multivariate analysis no factors independently predicted morbidity. On univariate analysis 90-day mortality was predicted by the grade of surgeries, a higher ASA grade, longer operative time, the use of more blood products, open surgeries and emergency surgeries. However on multivariate analysis only the use of more blood products was independently associated with mortalityConclusionThe 90-day mortality and morbidity rates between open and laparoscopic surgeries after the introduction of ERAS protocol were similar.
Exploring particulate matter pollution in hotel guestrooms
Authors: Chang Howook (Sean) , Huh Chang , Legendre Tiffany S. , Simpson John J. 
Published: April 2020

Purpose
A growing number of travelers seek well-being when traveling. As concerning about outdoor air pollution in tourism destinations escalates, little is known about indoor air pollution in hotel guestrooms. The purpose of the present study is to assess particulate matter (PM) pollution in US hotel guestrooms and to provide baseline indoor PM readings in occupied and unoccupied rooms.

Design/methodology/approach
A series of field tests and experiments monitoring PM levels were conducted in the guestrooms overnight – with and without occupants – using the sophisticated, industrial-grade PM-monitoring equipment.

Findings
The results revealed that PM levels were very low when rooms were unoccupied or when guests were asleep. However, unhealthy PM mass concentrations were observed in occupied rooms when guests engaged in physical activity such as showering and walking around or while room attendants cleaned rooms. Among the physical activities, room cleaning caused hazardous indoor PM pollution, reaching 1,665.9 µg/m3 of PM10 and 140.4 µg/m3 of PM2.5 although they tended to be brief.

Research limitations/implications
Leveraging increasing guest demand in well-being is essential for sustainable business and further growth. Indoor air quality must be recognized as an important factor to be controlled for well-being and health of guests and employees. Major hotel brands should take it into consideration as they infuse well-being DNA into their products and culture.

Originality/value
To the best of the authors’ knowledge, this study is the first empirical investigation of PM pollution both in occupied and unoccupied hotel guestrooms in the USA, which reveals unhealthy PM pollution associated with the routine human activities in occupied guestrooms.
Innovation through tradition in design-intensive family firms
Authors: Magistretti Stefano , Dell’Era Claudio , Frattini Federico , Messeni Petruzzelli Antonio 
Published: April 2020

PurposeSeveral studies show that identity is a critical success factor in design-intensive industries, leading managers and executives to identify solutions that enable firms to simultaneously innovate while preserving their link with the past. Accordingly, scholars have recently revealed the role of the so-called innovation through tradition strategy. Thus, the purpose of this study/paper is to understand how design intensive firms may exploit knowledge pertaining to the past.Design/methodology/approachThe research contributes to this line of inquiry by conducting a longitudinal analysis of two leading Italian design-intensive firms, B&B Italia and Cassina S.p.A. Specifically, through almost 30 h of interviews with 11 key informants and the analysis of various secondary sources, a unique database of over 900 products covering the period of 1960-2016 was developed.FindingsThe findings reveal that both firms leverage knowledge from the past mainly to preserve firm identity, as indicated by the two indicators used to capture the use of knowledge pertaining to the past (i.e., design tradition intensity and design tradition depth). In addition, the study shows that the values of these indicators significantly increase when ownership control shifts from family-based to fund-based.Originality/valueThe paper looks at design artifacts as a source of knowledge, exploring how they can support firms in reinforcing their identity. The original contribution to the design through traditional literature is in unveiling the product signs dimension of this particular innovation strategy.
Corporate social responsibility toward stakeholders and customer loyalty: investigating the roles of trust and customer identification with the company
Authors: Glaveli Niki 
Published: April 2020

PurposeThis study aims to uncover the underlying multiple intervening mechanisms between corporate social responsibility (CSR) and customer loyalty. Social identity and social exchange theories offer the ground for prediction that the primary outcomes of CSR initiatives are customer–company (C–C) identification and customer trust, which in turn affect customer loyalty. Also, the differential effect of CSR behaviors toward specific stakeholder groups on customer attitudes and behaviors are examined.Design/methodology/approachData were collected from 333 customers of telecommunication companies in Greece. Structural equation modeling was used to test the postulated relationships.FindingsThe findings demonstrate that both C–C identification and customer trust intervene in the relationship between customer perceptions of CSR and customer loyalty; however, the identification mechanism is stronger than the trust mechanism in building customer loyalty while C–C identification seems to drive customer trust. Moreover, out of the three CSR components (customers, employees, and society/environment) that were considered as relevant to customers and were investigated, customer-centric activities were found to be the stronger predictor of both C–C identification and customer trust. Also, CSR toward society/environment was found to positively influence C–C identification.Practical implicationsThe findings of this research can assist practitioners in effectively conceptualizing CSR image from a customers’ point of view and designing their company’s CSR and communication strategies to boost positive customer responses and strong long-term relationships.Originality/valueThe current study provides further insights into the complex relationship between CSR and customer responses and the impact that different CSR activities may have on customers.
Influence of the 2011 Tohoku tsunami on the genetic structure of wild sea urchin (Mesocentrotus nudus) populations in Sanriku, Japan
Authors: Adachi Kenta , Suzuki Takuya , Okumura Sei‐ichi , Funayama Shohei , Moriyama Shunsuke 
Published: April 2020

AbstractSea urchin (Mesocentrotus nudus) is a major marine resource of Sanriku off the Pacific Coast, Japan, that includes Aomori, Iwate, and Miyagi Prefectures. Using six microsatellites and three mitochondrial DNA regions, we aimed to characterize genetic diversity of M. nudus before and after the 2011 Tohoku earthquake in Sanriku's Touni and Okirai Bays. Although mass death during the Tohoku disaster likely reduced genetic diversity in M. nudus populations, we did not find significant genetic differentiation spatially (between the two bays) or temporally (pre‐ and post‐earthquake). Our data also suggest that M. nudus in Sanriku experienced a population expansion approximately 19–9 thousand years ago, during the long‐lasting, stable, and warm environment after the Last Glacial Maximum (LGM). We conclude that these M. nudus populations maintained their genetic structure throughout multiple disastrous tsunamis over the past several millennia; thus, they were also able to maintain their natural genetic structure and diversity after the 2011 earthquake.
Phosphoenolpyruvate carboxylase from the cyanobacterium Synechocystis sp. PCC 6803 is under global metabolic control by PII signaling
Authors: Scholl Jörg , Dengler Lisa , Bader Laura , Forchhammer Karl 
Published: April 2020

AbstractPhosphoenolpyruvate carboxylase (PEPC) is the second major carbon‐fixing enzyme in photoautotrophic organisms. PEPC is required for the synthesis of amino acids of the glutamate and aspartate family by replenishing the TCA cycle. Furthermore, in cyanobacteria, PEPC, together with malate dehydrogenase and malic enzyme, forms a metabolic shunt for the synthesis of pyruvate from PEP. During this process, CO2 is first fixed and later released again. Due to its central metabolic position, it is crucial to fully understand the regulation of PEPC. Here, we identify PEPC from the cyanobacterium Synechocystis sp. PCC 6803 (PEPC) as a novel interaction partner for the global signal transduction protein PII. In addition to an extensive characterization of PEPC, we demonstrate specific PII–PEPC complex formation and its enzymatic consequences. PEPC activity is tuned by the metabolite‐sensing properties of PII: Whereas in the absence of PII, PEPC is subjected to ATP inhibition, it is activated beyond its basal activity in the presence of PII. Furthermore, PII–PEPC complex formation is inhibited by ADP and PEPC activation by PII‐ATP is mitigated in the presence of 2‐OG, linking PEPC regulation to the cell's global carbon/nitrogen status. Finally, physiological relevance of the in vitro measurements was proven by metabolomic analyses of Synechocystis wild‐type and PII‐deficient cells.