bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening for Fabry Disease in Young Strokes in the Australian Stroke Clinical Registry (AuSCR)
Authors: Malavera Alejandra , Cadilhac Dominique A. , Thijs Vincent , Lim Joyce Y. , Grabsch Brenda , Breen Sibilah , Jan Stephen , Anderson Craig S. 
Published: November 2020

Introduction: Fabry disease (FD) is an X-linked lysosomal storage disorder characterized by a deficiency or absence of alpha-galactosidase A (α-GAL A) enzyme, where stroke can be a serious complication. The aim of this study is to determine the feasibility of centralized screening for FD, among young stroke adults registered in the national Australian Stroke Clinical Registry (AuSCR).Methods: The study was conducted in young (age 18 – 55 years) survivors of acute stroke of unknown etiology registered in AuSCR at hospitals in Queensland, Tasmania, New South Wales, and Victoria during 2014 – 2015; and who, at the 3-month outcome assessment, agreed to be re-contacted for future research. Descriptive analyses of case identification from responses and specific enzyme and DNA sequencing analyses were conducted for α-galactosidase A (α-GLA) from dried blood spot (DBS) testing.Results: Of 326 AuSCR-identified patients invited to participate, 58 (18%) provided consent but six were subsequently unable to provide a blood sample and two later withdrew consent to use their data. Among the remaining 50 participants (median age 53 years [48 – 56 years]; 47% female), 67% had experienced an acute ischemic stroke. All males (n = 27) had an initial screen for α-GLA enzyme activity of whom seven with low enzyme levels had normal secondary α-GLA gene analysis. All females (n = 23) had genetic analysis, with one shown to have a pathogenic c.352C&gt;T p.(Arg118Cys) missense mutation of the α-GLA gene for FD.Conclusions: These findings provide logistical data for embedding a process of automated central stroke registry screening for an additional case-finding tool in FD.
On the Relationship Between White Matter Structure and Subjective Pain. Lessons From an Acute Surgical Pain Model
Authors: Torrecillas-Martínez Laura , Catena Andrés , O'Valle Francisco , Solano-Galvis César , Padial-Molina Miguel , Galindo-Moreno Pablo 
Published: November 2020

Background: Pain has been associated with structural changes of the brain. However, evidence regarding white matter changes in response to acute pain protocols is still scarce. In the present study, we assess the existence of differences in brain white matter related to pain intensity reported by patients undergoing surgical removal of a mandibular impacted third molar using diffusion tensor imaging (DTI) analysis.Methods: 30 participants reported their subjective pain using a visual analog scale at three postsurgical stages: under anesthesia, in pain, and after the administration of an analgesic. The diffusion data were acquired prior to surgery.Results: DTI analysis yielded significant positive associations of fractional anisotropy in white matter areas related to pain processing (corticospinal tract, corona radiata, corpus callosum) with the differences in pain between the three postsurgery stages. Extent and location of these associations depended on the magnitude of the subjective pain differences. Tractography analysis indicated that some pain–tract associations are significant only when pain stage is involved in the contrast (posterior corona radiata), while others (middle cerebellar peduncle, pontine crossing) are only when anesthesia is involved in the contrast.Conclusions: The association of white matter fractional anisotropy and connectivity, measured before the pain stages, with subjective pain depends on the magnitude of the differences in pain scores.
Anxiety Status and Influencing Factors of Rural Residents in Hunan During the Coronavirus Disease 2019 Epidemic: A Web-Based Cross-Sectional Survey
Authors: Zhang Yi , Chen Yi-ping , Wang Jianjian , Deng Yanhong , Peng Dezhen , Zhao Liping 
Published: November 2020

Objective: To explore the status quo of anxiety and its influencing factors among rural residents in Hunan Province during the coronavirus disease 2019 epidemic, and to provide an effective basis for prevention of and intervention for anxiety symptoms among rural residents.Methods: Convenience sampling was used. An online questionnaire was distributed to Hunan rural residents through the questionnaire star platform from February 26–29, 2020. The general data and anxiety of Hunan rural residents were investigated, and the data were analyzed using SPSS 18.0.Results: The mean Self-Rating Anxiety Scale score of 179 rural residents in Hunan was 40.93 ± 9.36. Based on the cutoff criteria, 32 residents had anxiety, including 26 with mild anxiety, five with moderate anxiety, and one with severe anxiety. The detection rate of anxiety was 17.88%. Self-rated health status, level of concern about the epidemic, and self-rated impact of the epidemic on one's life were the factors influencing the anxiety score of rural residents in Hunan (P &lt; 0.05).Conclusion: During the coronavirus disease 2019 epidemic, the detection rate of anxiety in rural residents in Hunan was higher than that of the general population in China. The relevant departments should pay attention to the mental health of rural residents and implement targeted mental health prevention and intervention measures during the epidemic situation.
Masculinity and Help-Seeking Among Men With Depression: A Qualitative Study
Authors: Staiger Tobias , Stiawa Maja , Mueller-Stierlin Annabel Sandra , Kilian Reinhold , Beschoner Petra , Gündel Harald , Becker Thomas , Frasch Karel , Panzirsch Maria , Schmauß Max , Krumm Silvia 
Published: November 2020

Background: Many studies indicate that men are more reluctant to seek help for mental health problems than women. Traditional ideas of masculinity are often seen as a cause of this phenomenon. However, little is known about the diversity of experiences during the processes of help-seeking and service use among men with depression who have already utilized mental health services. This study aims to explore men's experiences and attitudes toward depression, help-seeking, and service use in order to develop gender-sensitive services.Methods: Narrative-biographical interviews were conducted with men treated for depression (n = 12). Interview topics included individual experience with depression, help-seeking behavior, and mental health service use. Transcripts were analyzed using qualitative content analysis.Results: Before seeking treatment, men's help-seeking behavior was negatively affected by internalized masculine norms. However, findings indicate a change of attitudes toward depression after mental health service use. Men with depression emphasized a salutogenic perspective toward mental health problems and critically reflected on masculine norms. The positive function of men-only groups were described as key for successful service use.Conclusions: Men with depression reported experiences toward help-seeking and service use on four different levels: (i) attitudes toward depression, (ii) perception of societal views on depression, (iii) experiences within the family context and (iv) experiences with mental health services. Interventions to reduce the stigma of being “unmanly” and to improve men's capacity to cope with being unable to work should be developed. Peer-led men-only groups may increase participants' self-esteem and assist in disclosing weaknesses. In the context of GPs' mediating role, training for health professionals concerning the impact of masculine norms on mental health is recommended.
Social Determinants Predict Outcomes in Data From a Multi-Ethnic Cohort of 20,899 Patients Investigated for COVID-19
Authors: Lundon Dara J. , Mohamed Nihal , Lantz Anna , Goltz Heather H. , Kelly Brian D. , Tewari Ashutosh K. 
Published: November 2020

Importance:The COVID-19 pandemic exploits existing inequalities in social determinants of health (SDOH) in disease burden and access to healthcare. Few studies have examined these emerging disparities using indicators of SDOH.Objective:To evaluate predictors of COVID-19 test positivity, morbidity, and mortality and their implications for inequalities in SDOH and for future policies and health care improvements.Design, Setting, and Participants:A cross sectional analysis was performed on all patients tested for COVID-19 on the basis of symptoms with either a history of travel to at risk regions or close contact with a confirmed case, across the Mount Sinai Health System (MSHS) up until April 26th 2020.Main Outcomes and Measures:Primary outcome was death from COVID-19 and secondary outcomes were test positivity, and morbidity (e.g., hospitalization and intubation caused by COVID-19).Results:Of 20,899 tested patients, 8,928 tested positive, 1,701 were hospitalized, 684 were intubated, and 1,179 died from COVID-19. Age, sex, race/ethnicity, New York City borough (derived from first 3 digits of zip-code), and English as preferred language were significant predictors of test positivity, hospitalization, intubation and COVID-19 mortality following multivariable logistic regression analyses.Conclusions and Relevance:People residing in poorer boroughs were more likely to be burdened by and die from COVID-19. Our results highlight the importance of integrating comprehensive SDOH data into healthcare efforts with at-risk patient populations.
Multiple long-term conditions within households and use of health and social care: a retrospective cohort study
Authors: Stafford Mai , Deeny Sarah R , Dreyer Kathryn , Shand Jenny 
Published: November 2020

BackgroundThe daily management of long-term conditions falls primarily on individuals and informal carers, but the impact of household context on health and social care activity among people with multiple long-term conditions (MLTCs) is understudied.AimTo test whether co-residence with a person with MLTCs (compared with a co-resident without MLTCs) is associated with utilisation and cost of primary, community, secondary health care, and formal social care.Design & settingLinked data from health providers and local government in Barking and Dagenham for a retrospective cohort of people aged ≥50 years in two-person households in 2016–2018.MethodTwo-part regression models were applied to estimate annualised use and cost of hospital, primary, community, mental health, and social care by MLTC status of individuals and co-residents, adjusted for age, sex, and deprivation. Applicability at the national level was tested using the Clinical Practice Research Datalink (CPRD).ResultsForty-eight per cent of people with MLTCs in two-person households were co-resident with another person with MLTCs. They were 1.14 (95% confidence interval [CI] = 1.00 to 1.30) times as likely to have community care activity and 1.24 (95% CI = 0.99 to 1.54) times as likely to have mental health care activity compared with those co-resident with a healthy person. They had more primary care visits (8.5 [95% CI = 8.2 to 8.8] versus 7.9 [95% CI = 7.7 to 8.2]) and higher primary care costs. Outpatient care and elective admissions did not differ. Findings in national data were similar.ConclusionCare utilisation for people with MLTCs varies by household context. There may be potential for connecting health and community service input across household members.
Treatment of uncomplicated UTI in males: a systematic review of the literature
Authors: Farrell Karen , Tandan Meera , Hernandez Santiago Virginia , Gagyor Ildiko , Braend Anja Maria , Skow Marius , Vik Ingvild , Jansaaker Filip , Hayward Gail , Vellinga Akke 
Published: November 2020

BackgroundUrinary tract infections (UTIs) affect around 20% of the male population in their lifetime. The incidence of UTIs in men in the community is 0.9–2.4 cases per 1000 aged <55 years and 7.7 per 1000 aged ≥85 years.AimTo evaluate the outcomes of randomised controlled trials (RCTs) comparing the effectiveness of different antimicrobial treatments and durations for uncomplicated UTIs in adult males in outpatient settings.MethodA systematic literature review of RCTs of adult male patients with an uncomplicated UTI treated with oral antimicrobials in any outpatient setting. The outcomes were symptom resolution within 2 weeks of starting treatment, duration until symptom resolution, clinical cure, bacteriological cure, and frequency of adverse events.ResultsFrom the 1052 abstracts screened, three provided sufficient information on outcomes. One study compared trimethoprim-sulfamethoxazole for 14 days (21 males) with 42 days (21 males). Fluoroquinolones were compared in the two other RCTs: lomefloxacin (10 males) with norfloxacin (11 males), and ciprofloxacin for 7 days (19 males) and 14 days (19 males). Combining the results from the three RCTs shows that for 75% males with a UTI (76/101) bacteriological cure was reported at the end of the study. Of the 59 patients receiving a fluoroquinolone, 57 (97%) reported bacteriological and clinical cure within 2 weeks after treatment.ConclusionThe evidence available is insufficient to make any recommendations in relation to type and duration of antimicrobial treatment for male UTIs. Sufficiently powered RCTs are needed to identify best treatment type and duration for male UTIs in primary care.
Prediksi Tipe Longsor di Desa Clapar Menggunakan Metode Geolistrik Resistivitas Konfigurasi Dipol-dipol
Authors: Muhardi Muhardi , Wahyudi Wahyudi 
Published: November 2020

Desa Clapar merupakan salah satu desa di Kabupaten Banjarnegara, Jawa Tengah, yang tergolong daerah rawan longsor. Tujuan penelitian ini adalah untuk memprediksi tipe longsor dengan menganalisis bidang gelincir berdasarkan sebaran nilai resistivitas secara lateral. Penelitian ini mengaplikasikan metode geolistrik resistivitas dengan konfigurasi dipol-dipol. Pengukuran dilakukan di dua lokasi, yaitu lereng bukit sebelah barat dan timur kawasan pemukiman, yang masing-masing terdiri dari 2 dan 3 lintasan pengukuran. Hasil penelitian menunjukkan bahwa bidang gelincir pada lokasi pertama mempunyai nilai resistivitas sebesar 2,93 - 47,43 Ωm, berupa lapisan lempung dengan bidang berbentuk relatif rata pada kedalaman 4,5 - 15,0 meter. Demikian juga dengan bidang gelincir pada lokasi kedua yang mempunyai nilai resistivitas sebesar 1,32 - 14,38 Ωm, berupa lapisan lempung dengan bidang berbentuk relatif rata pada kedalaman 1,5 - 7,0 meter. Hasil penelitian juga menunjukkan bahwa tipe longsor di Desa Clapar diprediksi sebagai longsor translasi.Kata kunci: bidang gelincir, Clapar, konfigurasi dipol-dipol, metode geolistrik resistivitas, tipe longsor Clapar Village is one of the village in Banjarnegara Regency, Central Java, which is classified as landslides prone area. This study aims to predict the landslides type by analyzing the slip surface based on the distribution of resistivity values laterally. This study applied the geoelectrical resistivity method of dipole-dipole configuration. The measurements were conducted in twoareas, on the hill slope western and eastern of the settlement area, which was consist of 2 and 3 lines, respectively. Thestudy results show that the slide surface in the first area has resistivity value of 2.93 - 47.43 Ωm inferred as relatively flat clay layer at a depth of 4.5 - 15.0 meters. While The slip surfacein the second area has a similar case with resistivity value of 1.32 - 14.38 Ωm inferred as a clay layer at a depth of 1.5 - 7.0 m. In addition, the landslides type in Clapar Village is predicted as a translational landslides. Keywords: slip surface, Clapar, dipole-dipole configuration, geoelectrical resistivity method, landslides type
Apendicectomía profiláctica en la dotación Antártica: Experiencia del Hospital de la Fuerza Aérea de Chile.
Authors: Uribe Sebastian , Vallejo Diego , Jorquera Mauricio , Contreras Luis , Celedón Felipe 
Published: November 2020

Objetivo: Reportar y caracterizar las complicaciones quirúrgicas de las apendicectomías laparoscópicas electivas profilácticas, realizadas a pacientes destinados a dotación antártica, realizadas en Hospital clínico de la Fuerza Aérea de Chile (FACh).Material y método: Análisis retrospectivo descriptivo de fichas clínicas de todos los pacientes sometidos a apendicectomía laparoscópica profiláctica entre los años 2013 y 2017 en Hospital FACh. Se registraron variables demográficas y quirúrgicas de los pacientes. Las complicaciones fueron registradas y clasificadas de acuerdo a Clavien-Dindo.Resultados: Se incluyeron 200 pacientes, 96% hombres y solo 4% mujeres. Se registraron 6 pacientes (3%) con complicaciones quirúrgicas, clasificadas como Grado I según Clavien-Dindo.Discusión: No existen reportes de complicaciones en apendicectomías profilácticas. En nuestra serie éstas alcanzan el 3%Conclusiones: La apendicectomía profiláctica es una cirugía segura, con escasas complicaciones, pero existen y se desarrollan en un paciente que estaba previamente sano.
Analisa Laju Pertumbuhan Silika Scaling Pada Pipa Air Kondensat Scrubber Unit 5 Di Industri Geotermal
Authors: Puji Astuti Ibrahim  , Ahda Nur Fajri  
Published: November 2020

Industri panas bumi merupakan sumber energi alternatif yang ramah lingkungan serta dapat di perbaharui, selain dengan banyaknya keunggulan dari energi panas bumi terdapat juga kekurangan salah satunya scale.Jenis scale yang terdapat pada PLTP Kamojang adalah silka. Silika scaling merupakan jenis mineral yang paling sedikit komposisinya tetapi memiliki kekerasan paling tinggi, karena itu perlu di lakukan analisis tentang kemungkinan terjadinya pengendapan silika scaling dan berapa cepat pertumbuhan silika dan bagai mana cara menanggulanginya. Pada hasil analisi semala 8 hari di temukan pengendapan paling besar 0,00167 in3/tahun atau 0,274 cm3/tahun, jumlah tersebut masih di bawah standar dari perusahaan. Mengingat scaling dapat menghambat produksi pada industri maka scaling harus di minimalisir pertumbuhannya dengan cara menjaga kelarutan mineral dengan menyemprotkan air pada scrubber dan juga dengan menambahkan inhibitor HCl.
On non-adjacent letter repetition and orthographic processing: Lexical decisions to nonwords created by repeating or inserting letters in words
Authors: Kerr Emilia , Mirault Jonathan , Grainger Jonathan 
Published: November 2020

AbstractInformal observation suggests that it is harder to notice the spelling mistake in “silencne” than “silencre.” This concurs with current evidence that non-adjacent letter repetition in correctly spelled words makes these words harder to recognize. One possible explanation is provided by open-bigram coding. Words containing repeated letters are harder to recognize because they are represented by fewer bigrams than words without repeated letters. Building on this particular explanation for letter-repetition effects in words, we predicted that nonwords in a lexical decision task should also be sensitive to letter repetitions. In particular, we examined two types of nonwords generated from the same baseword: (1) nonwords created by repeating one of the letters in the baseword (e.g., silence => silencne); and (2) nonwords created by inserting a letter that is not present in the baseword (e.g., silencre). According to open-bigram coding, nonwords created by repeating a letter are more similar to their baseword than nonwords created by inserting a letter, and this should make it harder to reject letter repetition nonwords than letter insertion nonwords. We put these predictions to test in one on-line pilot study (n=31), one laboratory experiment (n=36), and one follow-up on-line experiment (n=40) where we manipulated the distance between repetitions (one, two, three, or four letters). Participants found it harder to reject repetition nonwords than insertion nonwords, and this effect diminished with increasing distance.
Pengaruh Ukuran Perusahaan, Risiko Perusahaan, dan Profitabilitas Klien Terhadap Audit Fee
Authors: Fisabilillah Pra Dhita , Fahria Rahmasari , Praptiningsih Praptiningsih 
Published: November 2020

This research is a quantitative study that aims to determine the effect of company size, company risk, and client profitability on audit fees. The population in this study are manufacturing companies listed on the Indonesia Stock Exchange for the period of 2016-2018 which were selected using purposive samples. The number of observations is 99 samples. The analysis technique used in this study is multiple linear regression analysis using SPSS 25 software with a significance level of 5%. The results of the test show that (1) company size has a positive effect on audit fees (2) company risk has no effect on audit fees, and (3) client profitability has a positive effect on audit fees.

Keywords: Company Size, Company Risk, Client Profitability, Audit Fee
The Effect Of Profesional Ethics, Time Budget Pressure, Professional Skepticsm On Audit Quality
Authors: Krisdayanti Monica Indah , Andesto Ronny , Praptiningsih Praptiningsih 
Published: November 2020

This study aims to examine the effect of professional ethics, time budget pressure, professional skepticism on audit quality. The population in this study was auditors working at BPK Republic of Indonesia. Sampling was carried out using the puruposive method. The data analysis used in this study used the PLS program with a significance level of 5%. The results of this study indicate that (1) professional ethics has a significant effect on audit quality, (2) time budget pressure has no significant effect on audit quality, (3) professional skepticism has no significant effect on audit quality.
Keywords: Professional Ethics; Time Budget Pressure; Professional Skepticism; Audit Quality
Comparison of Morphological Features of Type 1 CNV in AMD and Pachychoroid Neovasculopathy: An OCTA Study
Authors: Biçer Özlem , Demirel Sibel , Yavuz Zeynep , Batioğlu Figen , Özmert Emin 
Published: November 2020

BACKGROUND AND OBJECTİVE:
The purpose of this study is to compare the morphological features of type 1 choroidal neovascularization (CNV) in eyes with age-related macular degeneration (AMD) and pachychoroid neovasculopathy (PNV) using optical coherence tomography angiography (OCTA).

PATİENTS AND METHODS:
Nineteen eyes of 17 patients with PNV and 30 eyes of 30 patients with AMD were evaluated. The size and area of CNV and morphological patterns during a 6-month period were analyzed using optical coherence tomography angiography.

RESULTS:
The presence of a feeder vessel was more common in AMD than in PNV. Indistinct pattern was more common in PNV than AMD. Pruned vascular tree pattern was rare in PNV eyes during follow-up. The mean size and flow of selected CNV area was significantly smaller in PNV group.

CONCLUSİON:
This study demonstrated that type 1 CNVs in the PNV group is characterized by a smaller area. Morphologic pattern differences between them might be explained by different etiopathogenesis under these circumstances.

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Ophthalmic Surg Lasers Imaging Retina.
2020;51:640–647.]
Case Report: Protracted Eosinophilic Meningitis due to Probable Angiostrongyliasis
Authors: Mansbridge Christopher T. , Norton Nicholas J. , Fox Simon M. 
Published: November 2020

ABSTRACTEosinophilic meningitis is classically caused by Angiostrongylus cantonensis. Treatment usually includes supportive care and corticosteroids. Anthelminthic drugs are often avoided because of the risk of an inflammatory reaction to dying larvae. The duration of symptoms in most cases is up to a few weeks. We describe a case of eosinophilic meningitis, likely due to Angiostrongylus spp. infection, with recurrent symptoms and persistent cerebrospinal fluid eosinophilia despite corticosteroid treatment, over a period of almost 5 months. This only resolved after treatment with albendazole.