bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and implementation of smart waste recycling bin for the household environment based on IoT
Authors: Harjoseputro Yulius , Julianto Eddy , Handarkho Yonathan Dri , Ritonga Yuriska Indriati Talenta 
Published: October 2020

Purpose
This study aims to build a prototype of a smart waste recycling bin to transform organic waste into liquid fertilizer. The internet of things (IoT) was used as a base to develop this bin to offer a recycling system that convenient to the household.

Design/methodology/approach
In general, this system will integrate a microcontroller and several sensors that able to be controlled by a smartphone app to manage the decomposition process of organic waste in the bin. In the end, black-box testing was conducted to ensure all hardware and software that construct the system can perform well as expected.

Findings
All the validation testing reveals all the integration of hardware and software that constructs the smart bin satisfied the performance requirement except for the real-time clock sensor that implies the slight error for a few seconds compares to the actual time.

Originality/value
Different from the previous works, this study focused on the involvement of society to participate in the recycling garbage process by designing the smart waste recycling bin system that fits to locate in the household environment, which allows users to monitor the fertilizer making process using IoT technology.
Fosravuconazole to treat severe onychomycosis in the elderly
Authors: Noguchi Hiromitsu , Matsumoto Tadahiko , Kimura Utako , Hiruma Masataro , Kano Rui , Kubo Masahide , Fukushima Satoshi , Ihn Hironobu 
Published: October 2020

AbstractFosravuconazole is a novel oral antifungal drug developed in Japan and used to treat tinea unguium since 2018. Its excellent oral absorbability and systemic bioavailability has enabled short‐duration therapy of 3 months. Furthermore, no concomitant drugs are contraindicated due to the presence of the mild inhibitor of cytochrome P450 enzyme which is responsible for polypharmacy adverse effects. Therefore, it can be safely administrated to elderly patients. Elderly patients (≥65 years old) with severe onychomycosis (≥50% nail involvement) were treated with oral fosravuconazole 100 mg once daily for 12 weeks. The rate of involvement improved from 86.6% to 28.1% (P < 0.01). The efficacy (i.e. percentage of those rated as “improved” and better) and cure rate was 83.8% (31/37) and 29.7% (11/37), respectively. Furthermore, when focusing on the thin nail group (<3 mm), the efficacy and cure rate was 88.2% (15/17) and 58.8% (10/17), respectively. Although the serum γ‐glutamyltransferase levels increased in 21.6% (8/37), all patients recovered without any specific treatments.
Improved quality of life of patients with generalized pustular psoriasis in Japan: A cross‐sectional survey
Authors: Hayama Koremasa , Fujita Hideki , Iwatsuki Keiji , Terui Tadashi 
Published: October 2020

AbstractGeneralized pustular psoriasis (GPP) is a rare variant of psoriasis with severe clinical symptoms. However, the quality of life (QoL) of the patients is largely unknown. We conducted a nationwide cross‐sectional survey of Japanese GPP patients using the 36‐Item Short‐Form Health Survey version 2 (SF‐36v2) to elucidate patients’ QoL and how their QoL had changed over the last decade. We analyzed QoL data of 83 patients obtained from 2016 to 2019 (present group) and compared it with that of 105 patients collected in a previous survey conducted between 2003 and 2007 (past group). Although the QoL of the present patients was still largely impaired in comparison with the standard Japanese population, substantial improvement was found in some SF‐36v2 subscales including “general health”, “vitality”, “social functioning” and “mental health” as compared with that of the past group. Advances in treatment may contribute to this QoL improvement.
Spirits out of place: relational landscapes and environmental change in East Kalimantan, Indonesia
Authors: Herrmans Isabell 
Published: October 2020

AbstractThis article examines interaction with spirits among the Luangan, a group of shifting cultivators in Indonesian Borneo. Through examples of different forms of Luangan spirit interaction, it interrogates the relationship between the spirit world and the natural environment, with special reference to what happens when the latter undergoes dramatic change. Inspired by Eduardo Kohn's understanding of how the spirit world is semiotically embedded within the rainforest environment, I explore how relations with nonhumans reflect historical and ongoing experiences of life and sociality in the forest and human domain, while superimposing a virtual relational landscape upon the natural landscape. It is proposed that spirit communication offers a means of refiguring human lives and alleviating debilitation, and that recurrent rituals enable Luangans to virtually maintain relations with unseen beings of the local environment, even where it has been thoroughly transformed through oil palm cultivation.
Understanding the social and cultural bases of Brexit*
Authors: Chan Tak Wing , Henderson Morag , Sironi Maria , Kawalerowicz Juta 
Published: October 2020

AbstractWe use data from a large scale and nationally representative survey to evaluate two narratives about the social bases of Brexit. The first narrative sees Brexit as a revolt of the economically left‐behinds. The second narrative attributes Brexit to the resurgence of an English nationalism. There is some, albeit not always consistent, evidence that people in relative poverty or those living in areas that have seen greater Chinese import penetration are slightly more pro‐Leave. People living in economically deprived neighborhoods are not more pro‐Brexit. Using the Weberian class–status distinction, it is social status, not social class, which stratifies Brexit support. Individuals for whom being British is important are more pro‐Leave. But those who see themselves as British rather than English, and those reporting omnivorous cultural consumption are less supportive of Brexit. Overall, there is empirical support for both narratives. But the weight of the evidence suggests a strong cultural dimension in Brexit support.
Market Reactions to Central Bank Interest Rate Changes: Evidence from the Chinese Stock Market*
Authors: Hu Jun , Jiang George J. , Pan Guanzhong 
Published: October 2020

AbstractContrary to theoretical expectations and empirical evidence in developed markets, the Chinese stock market reacts positively (negatively) to interest rate increases (cuts) by the central bank. During the period from January 1996 to December 2016, the Shanghai Composite Index had an average abnormal return of 1.07% (−1.85%) in reaction to interest rate increases (cuts) over the two‐day announcement window. We further demonstrate that short‐term market reactions are transitory and have no permanent effect. Finally, we reveal that short‐term market reactions cannot be explained by market frictions or information uncertainty. Rather, such reactions are likely driven by investor sentiment.
IL1B triggers inflammatory cytokine production in bovine oviduct epithelial cells and induces neutrophil accumulation via CCL2
Authors: Nakamura Yuki , Aihara Riho , Iwata Hisataka , Kuwayama Takehito , Shirasuna Koumei 
Published: October 2020

AbstractProblemThe oviduct is essential for reproduction. We previously showed that oviduct epithelial cells (OECs) isolated from aged cows expressed higher levels of inflammatory cytokines, including interleukin (IL) 1A and IL1B. In addition, aging is associated with tissue dysfunction and cellular senescence via a senescence‐associated secretory phenotype (SASP) and immune cell accumulation. We investigated whether IL1A or IL1B causes SASP production, cellular senescence, and inflammatory responses in bovine OECs.Method of StudyThe OECs were isolated from bovine oviducts from young (mean 50.3 months) and aged cows (mean 157.0 months) and cultured.ResultsTreatment with IL1A or IL1B induced SASP production (IL8, IL6, TNFA, and CCL2) and mRNA expression of cell adhesion molecules in bovine OECs, but both IL1s did not induce cellular senescence in OECs and migration of polymorphonuclear neutrophils (PMNs). Cultured medium of OECs treated with IL1s, especially IL1B, dramatically induced PMN migration. Treatment with the CCL2 inhibitor, but not IL8 or its receptor CXCR2 inhibitors, significantly reduced immune cell migration in IL1B‐treated OEC‐cultured medium. Treatment with IL1B increased PMN adhesion to OECs, resulting in further SASP production in OECs due to a PMN‐OEC interaction.ConclusionWe suggest that senescence‐associated IL1s cause SASP production in bovine OECs and CCL2 induced by IL1B is essential for the migration of immune cells to OECs. Specifically, IL1B regulates PMN migration and adhesion to bovine OECs, and PMNs accelerate inflammatory cytokine production from bovine OECs via a direct interaction. These phenomena may contribute to chronic oviductal inflammation, resulting in subfertility.
Knowing minds: Linking early perspective taking and later metacognitive insight
Authors: Kloo Daniela , Sodian Beate , Kristen‐Antonow Susanne , Kim Sunae , Paulus Markus 
Published: October 2020

Recent metacognitive research using a partial knowledge task indicates that a firm understanding of ‘knowing about knowing’ develops surprisingly late, at around 6 years of age. To reveal the mechanisms subserving this development, the partial knowledge task was used in a longitudinal study with 67 children (33 girls) as an outcome measure at 5;9 (years;months). In addition, first‐ and second‐order false belief was assessed at 4;2, 5;0, and 5;9. At 2;6, perspective taking and executive abilities were evaluated. Metacognition at 5;9 was correlated with earlier theory of mind and perspective taking – even when verbal intelligence and executive abilities were partialled out. This highlights the importance of perspective taking for the development of an understanding of one’s own mind.
Chronic pain in the time of COVID‐19: Stress aftermath and central sensitization
Authors: Serrano‐Ibáñez Elena R. , Esteve Rosa , Ramírez‐Maestre Carmen , Ruiz‐Párraga Gema T. , López‐Martínez Alicia E. 
Published: October 2020

ObjectivesThe COVID‐19 crisis is a significant stressor worldwide. The physical and emotional condition of individuals with pain sensitization syndromes who are experiencing the pandemic may worsen. This study investigated the contribution of life changes due to the coronavirus to emotional distress in individuals with a diagnosis of chronic central sensitization pain and tested whether the associations between level of pain and sensitization were independent of or mediated by emotional distress.MethodsSpanish individuals with chronic pain (N = 362) completed an online survey on direct or indirect exposure to the consequences of COVID‐19, pain intensity, and emotional distress. They also completed central sensitization questionnaires.ResultsAn association was found between changes in daily routines and pain intensity, emotional distress, and sensitization scores. Correlations were found between emotional distress, sensitization, and pain intensity. Significant predictors of emotional distress were age, difficulty in receiving medical care, changes in daily routines, and diminished social support. Emotional distress did not mediate the association between sensitization and pain intensity.ConclusionDue to the COVID‐19 situation, individuals with central sensitization pain syndromes may be at higher risk of developing psychological distress. Interdisciplinary interventions involving psychologists are urgently needed to provide this population with appropriate health care.
Resilience during uncertainty? Greater social connectedness during COVID‐19 lockdown is associated with reduced distress and fatigue
Authors: Nitschke Jonas P. , Forbes Paul A. G. , Ali Nida , Cutler Jo , Apps Matthew A. J. , Lockwood Patricia L. , Lamm Claus 
Published: October 2020

BackgroundSocial connections are crucial for our health and well‐being. This is especially true during times of high uncertainty and distress, such as during the COVID‐19 lockdown. This period was characterized by unprecedented physical distancing (often communicated as social distancing) measures resulting in significant changes to people’s usual social lives. Given the potential effects of this disruption on people’s well‐being, it is crucial to identify factors which are associated with negative health outcomes, and conversely, those that promote resilience during times of adversity.AimsWe examined the relationship between individuals’ levels of social connectedness during lockdown and self‐reported stress, worry, and fatigue. Method: Survey data were collected from 981 individuals in a representative sample of Austrian citizens. Data collection occurred during the last week of a six‐week nationwide lockdown due to the COVID‐19 pandemic. The final sample consisted of 902 participants. Participants were asked to complete validated questionnaires to assess levels of social connectedness as well as measures of perceived stress, worry—both general and COVID‐19 specific—and symptoms of fatigue during the previous two weeks.ResultsOur results demonstrate that greater social connectedness during the lockdown period was associated with lower levels of perceived stress, as well as general and COVID‐19‐specific worries. Furthermore, we found a negative relationship between fatigue and social connectedness, which was mediated by feelings of stress, general worries, and COVID‐19‐specific worries—respectively, indicating that individuals with smaller network sizes, who were highly distressed during the pandemic, were also likely to report feeling more fatigued.ConclusionOur findings highlight the important role that social connections play in promoting resilience by buffering against negative physical and mental health outcomes, particularly in times of adversity in times of adversity.
Living in limbo: Economic and social costs for refugees
Authors: Ukrayinchuk Nadiya , Havrylchyk Olena 
Published: October 2020

AbstractOur paper tests the hypothesis that living in limbo could have negative consequences for the socio‐economic integration of refugees. We define limbo as a protracted period when asylum seekers are waiting for the decision concerning their permanent refugee status. Relying on the French survey of migrants, France's longitudinal survey of migrants (ELIPA), we measure integration by labour market participation, fluency in French, finding new French friends and studying. To account for the endogeneity of limbo, we instrument it with the administrative backlog. We find that living longer in limbo during the asylum‐seeking period slows down future integration of refugees, but results differ with respect to gender and educational attainment. While having lived longer in limbo slows down most aspects of socio‐economic integration for refugees with no degree or a high school degree, those with a bachelor's degree do not experience negative effects. Male refugees who had lived longer in limbo have a lower likelihood of being employed and studying in France, while similar females make fewer French friends.
Atrioventricular, ventriculoarterial discordance and Ebstein malformation of the tricuspid valve with severe regurgitation resulting in aortic atresia in a neonate
Authors: Karmegaraj Balaganesh , Ibrahim Syed , Razeen Mohamed , Naseeha Ayesha , Srimurugan Balaji 
Published: October 2020

AbstractAortic atresia is uncommonly associated with atrioventricular and ventriculoarterial discordance. Presence of severe regurgitation of Ebstein malformation of the tricuspid valve in this subset results in reduced aortic blood flow in‐utero. We report here a term neonate with this anomaly detected antenatally.
Utility of global longitudinal strain to detect significant coronary artery disease, its extent and severity in patients with stable ischemic heart disease
Authors: Biswas Kaushik , Mukherjee Anindya , Nandi Saumen , Khanra Dibbendhu , Sharma Ranjan Kumar , Maji Sujata 
Published: October 2020

AbstractBackgroundEarly changes in cardiac function due to ischemia may be detected by global longitudinal peak systolic strain (GLS). Till date, no Indian data exist regarding role of GLS in stable ischemic heart disease (SIHD) and data showing correlation of GLS and SYNTAX score (SS) is meager in world literature. Our aim was to ascertain the role of GLS in SIHD.MethodsOne hundred and seventeen subjects with angina and normal transthoracic echocardiogram (TTE) underwent strain echocardiography and coronary angiography (CAG).ResultsThere was significant correlation between GLS and SS values (R2 = .686, P < .0001). The correlation was weaker yet significant in the low SS (<22) group (R2 = .491, P < .0001) and high SS (≥22) group (R2 = .602, P < .0001). The cutoff value of GLS to detect significant CAD was −16.5 (87.6% sensitivity, 85.7% specificity, P < .0001), to predict high SS was −13.5% (sensitivity 78.3%, specificity 87.9%, P < .0001) and to predict triple vessel disease (TVD) was −14.5 (95.7% sensitivity, 73.4% specificity, P < .0001). The agreement between GLS and CAG for detection of significant CAD was substantial (κ = 0. 676, P < .0001), similar to that between territorial strain and CAG in detecting LAD disease (κ = 0.688, P < .0001) while agreement between strain imaging and CAG for detecting number of vessels diseased was moderate (κ = 0.406, P < .0001).ConclusionGlobal longitudinal peak systolic strain must be conducted on subjects with angina and inconclusive electrocardiogram (ECG) findings to rule out significant CAD even if conventional TTE was normal. This may facilitate early diagnosis of CAD or sub‐clinical left ventricular systolic dysfunction (LVSD), preventive or treatment measures, and overall cost savings.
Using the MoBI motion capture system to rapidly and accurately localize EEG electrodes in anatomic space
Authors: Mazurek Kevin A. , Patelaki Eleni , Foxe John J. , Freedman Edward G. 
Published: October 2020

AbstractDuring mobile brain/body imaging (MoBI) experiments, electroencephalography and motion capture systems are used in concert to record high temporal resolution neural activity and movement kinematics while participants perform demanding perceptual and cognitive tasks in a naturalistic environment. A typical MoBI setup involves positioning multi‐channel electrode caps based on anatomical fiducials as well as experimenter and participant intuition regarding the scalp midpoint location (i.e., Cz). Researchers often use the “template” electrode locations provided by the manufacturer, however, the “actual” electrode locations can vary based on each participant's head morphology. Accounting for differences in head morphologies could provide more accurate clinical diagnostic information when using MoBI to identify neurological deficits in patients with motor, sensory, or cognitive impairments. Here, we asked whether the existing motion capture system used in a MoBI setup could be easily adapted to improve spatial localization of electrodes across participants without requiring additional or specialized equipment that might impede clinical adoption. Using standard electrode configurations, infrared markers were placed on a subset of electrodes and anatomical fiducials, and the remaining electrode locations were estimated using spherical or ellipsoid models. We identified differences in event‐related potentials between “template” and “actual” electrode locations during a Go/No‐Go task (p < 9.8e–5) and an object‐manipulation task (p < 9.8e–5). Thus, the motion capture system already used in MoBI experiments can be effectively deployed to accurately register and quantify the neural activity. Improving the spatial localization without needing specialized hardware or additional setup time to the workflow has important real‐world implications for translating MoBI to clinical environments.
Haematogenous septic arthritis, physitis and osteomyelitis in foals: A tutorial review on pathogenesis, diagnosis, treatment and prognosis. Part 1
Authors: Lindegaard C. , van Galen G. , Aarsvold S. , Berg L. C. , Verwilghen D. 
Published: October 2020

SummaryHaematogenous septic arthritis, physitis and osteomyelitis (SAPO) is a potentially debilitating or even life‐threatening disease entity encountered in foals of all ages between birth and approximately 7 months old. Correct, and complete, diagnosis and successful treatment require collaboration between specialties including medicine, anaesthesia, diagnostic imaging, surgery and rehabilitation services. However, in order to succeed, it is important that all specialties have an overall knowledge of all aspects of the disease complex. Therefore, the aim of this review is to give an overview of aetiology, presenting complaints, clinical findings, diagnostic imaging, treatment, rehabilitation and prognosis. Part one deals with all aspects of aetiology and how to make a diagnosis. Part two deals with all aspects of treatment, rehabilitation and prognosis.
Acute myeloid leukemia with mutated NPM1 mimics acute promyelocytic leukemia presentation
Authors: Arana Rosainz Manuel J. , Nguyen Nghia , Wahed Amer , Lelenwa Laura C. , Aakash Nfn , Schaefer Karen , Rios Adan , Kanaan Zeyad , Chen Lei 
Published: October 2020

AbstractObjectivesTo investigate clinicopathological and molecular features of NPM1‐mutated acute myeloid leukemia that presented with infrequent acute promyelocytic leukemia (APL)‐like phenotype and clinical presentation.MethodsCases with both de novo or secondary Acute Myeloid Leukemia (AML) were retrieved. Data from flow cytometry immunophenotyping, cytogenetics, molecular studies, and clinical presentation were analyzed.ResultsCases presented with abnormal coagulation parameters and low platelets count; four of them showed a DIC index compatible with overt DIC. Two cases showed Auer rods. In all cases, immunophenotypes mimicked APL: blasts expressed CD33, CD13, and cytoplasmic MPO but did not express CD34, HLA‐DR, or CD11b. Notably, CD4 expression was observed in all cases. Neither t(15;17) nor PML/RARα gene rearrangement was detected. NPM1 gene mutation was identified in all cases. In four cases, TET2 or IDH2 co‐mutations were identified.ConclusionsOur findings provide additional evidence of association between NPM1‐mutated AML with TET2 or IDH2 co‐mutations and the APL‐like immunophenotype. This AML subset was found to exist in both de novo and secondary AML. High WBC count and blasts with low to moderate side scatter and significant expression of CD4 are observed features that could assist in the differential diagnosis with APL. The occurrence of significant elevated D‐dimer levels, or even overt DIC observed at diagnosis in these cases could be relevant for this AML subtype.