bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of treatment with a full-occlusion biofeedback splint on sleep bruxism and TMD pain: a randomized controlled clinical trial
Authors: Bergmann Alexander , Edelhoff Daniel , Schubert Oliver , Erdelt Kurt-Jürgen , Pho Duc Jean-Marc 
Published: May 2020

Abstract
Objectives
The purpose of the present study was to analyze treatment outcome with a full-occlusion biofeedback (BFB) splint on sleep bruxism (SB) and TMD pain compared with treatment with an adjusted occlusal splint (AOS).

Materials and methods
Forty-one patients were randomly allocated to a test (BFB) or a control (AOS) group and monitored over a 3-month period. Output variables were frequency and duration of bruxing events (bursts) and various pain symptoms.

Results
The BFB group showed a statistically significant reduction in the frequency and duration of bursts and a statistically significant improvement in the patients’ global well-being and the facial muscle pain parameter. After the treatment was stopped, the BFB group showed a statistically significant reduction in the average and maximum duration but no statistically significant change in the frequency of bursts.

Conclusions
The tested BFB splint is highly effective in reducing SB at the subconscious level, i.e., without waking the patient, and in achieving improvements in global pain perception. The results suggest that the BFB splint also provides a better treatment option for bruxism-related pain than an AOS. However, further research is needed, and specifically studies with a larger patient population displaying higher levels of pain at baseline.

Clinical relevance
By reducing burst duration and therefore the pathological load on the masticatory apparatus, the BFB splint reduces TMD and bruxism-related symptoms and improves patients’ physical well-being. In the long term, this could prevent damage to the TMJ. This study confirms the effectiveness and safety of this splint.

The universal trial number
U1111-1239-2450

DRKS-ID registration
DRKS00018092
Improvement in d-xylose utilization and isobutanol production in S. cerevisiae by adaptive laboratory evolution and rational engineering
Authors: Promdonkoy Peerada , Mhuantong Wuttichai , Champreda Verawat , Tanapongpipat Sutipa , Runguphan Weerawat 
Published: May 2020

Abstract
As the effects of climate change become apparent, metabolic engineers and synthetic biologists are exploring sustainable sources for transportation fuels. The design and engineering of microorganisms to produce gasoline, diesel, and jet fuel compounds from renewable feedstocks can significantly reduce our dependence on fossil fuels as well as lower the emissions of greenhouse gases. Over the past 2 decades, a considerable amount of work has led to the development of microbial strains for the production of advanced fuel compounds from both C5 and C6 sugars. In this work, we combined two strategies—adaptive laboratory evolution and rational metabolic engineering—to improve the yeast Saccharomyces cerevisiae’s ability to utilize d-xylose, a major C5 sugar in biomass, and produce the advanced biofuel isobutanol. Whole genome resequencing of several evolved strains followed by reverse engineering identified two single nucleotide mutations, one in CCR4 and another in TIF1, that improved the yeast’s specific growth rate by 23% and 14%, respectively. Neither one of these genes has previously been implicated to play a role in utilization of d-xylose. Fine-tuning the expression levels of the bottleneck enzymes in the isobutanol pathway further improved the evolved strain’s isobutanol titer to 92.9 ± 4.4 mg/L (specific isobutanol production of 50.2 ± 2.6 mg/g DCW), a 90% improvement in titer and a 110% improvement in specific production over the non-evolved strain. We hope that our work will set the stage for an economic route to the advanced biofuel isobutanol and enable efficient utilization of xylose-containing biomass.
Nourishing Compassion in Finnish Kindergarten Head Teachers: How Character Strength Training Influences Teachers’ Other-Oriented Behavior
Authors: Vuorinen Kaisa , Pessi Anne Birgitta , Uusitalo Lotta 
Published: May 2020

AbstractCompassion refers to noticing, feeling and acting to alleviate suffering in others. Being one of the crucial socio-emotional and cultural skills, surprisingly little is known of early childhood education (ECE) teachers’ compassionate behavior and their ability to teach it to children. Overall, research on compassion in early childhood education and care (ECEC) settings is scarce. However, existing studies show that compassion skills can be acquired through training, and a collective compassion capability can be cultivated by everyday practices. As part of the positive psychology movement, compassion can be viewed as one of the character strengths (Peterson and Seligman 2004), generic skills, or “soft skills” that are underlined in the latest curricula and pedagogical documents (OECD 2017). In our present study, 95 ECE head teachers participated in the interventions, the aim of which was promoting compassion, character strengths and a supportive organization culture. A classic controlled pre/post-measuring protocol was applied to monitor progress. Additionally, qualitative material was collected from 33 participants. The intervention participants showed a significant increase in their identification and usage of strengths and in creating a supportive organizational culture. Content analysis of the qualitative statements revealed three main themes,Caring professionalism,Warm presenceandPositive feedback, evidencing strivings toward an emotionally and professionally supportive ECEC organization.
Private providers and market exit in UK higher education
Authors: Hunt Stephen A. , Boliver Vikki 
Published: May 2020

AbstractThe sudden closure of higher education providers is virtually unknown among publicly funded higher education institutions in the UK, but “market exit” is commonplace among private higher education providers. The UK government is actively championing the expansion of private higher education providers despite a dearth of research on the factors associated with a heightened risk of market exit within this part of the UK higher education sector. We set out to fill this gap in knowledge by utilizing existing data on private higher education providers active in the UK in 2014 supplemented by newly collected data on the status of these providers in 2019. The likelihood of market exit was higher for more recently founded providers, those operating for profit, those specializing in Business or IT or else having no particular specialization, and those located in London—all features that represent areas of greatest competition in the private higher education sector. Further risk factors associated with an increased likelihood of market exit were no external quality assessment, no access to publicly backed tuition fee loans, and the removal of the legal right to recruit international students. This second set of risk factors suggest that it is not just denial of revenue streams that increases the likelihood of market exit but estrangement from an officially regulated higher education system.
Short-term outcome following surgery for rare brain tumor entities in adults: a Swedish nation-wide registry-based study and comparison with SEER database
Authors: Bartek Jiri , Dhawan Sanjay , Thurin Erik , Alattar Ali , Gulati Sasha , Rydenhag Bertil , Henriksson Roger , Chen Clark C. , Jakola Asgeir Store 
Published: May 2020

Abstract
Objective
To investigate outcomes after surgery for rare brain tumors using the Swedish Brain Tumor Registry (SBTR).

Methods
This is a nationwide study of patient in the SBTR, validated in the Surveillance, Epidemiology, and End Results (SEER) registries. We included all adults diagnosed 2009–2015 with a rare brain tumor entity (n = 216), defined as ependymoma (EP, n = 64), subependymoma (SUBEP, n = 21), ganglioglioma (GGL, n = 54), pilocytic astrocytoma (PA, n = 56) and primitive neuroectodermal tumor (PNET, n = 21). We analyzed symptomatology, tumor characteristics and outcomes.

Results
Mean age was 38.3 ± 17.2 years in GGL, 36.2 ± 16.9 in PA, 37.0 ± 19.1 in PNET, 51.7 ± 16.3 in EP and 49.8 ± 14.3 in SUBEP. The most common symptom was focal deficit (39.6–71.4%), and this symptom was most common in GGL patients with 64.2% of GGL presenting with seizures. Most patients had no or little restriction in activity before surgery (Performance Status 0–1), although up to 15.0% of PNET patients had a performance status of 4. Gross total resection was achieved in most (> 50%) tumor categories. Incidence of new deficits was 11.1–34.4%. In terms of postoperative complications, 0–4.8% had a hematoma of any kind, 1.9–15.6% an infection, 0–7.8% a venous thromboembolism and 3.7–10.9% experienced a complication requiring reoperation. There were 3 deaths within 30-days of surgery, and a 1-year mortality of 0–14.3%.

Conclusion
We have provided benchmarks for the current symptomatology, tumor characteristics and outcomes after surgery for rare brain tumors as collected by the SBTR and validated our results in an independent registry. These results may aid in clinical decision making and advising patients.
Direct cryopreservation of winter-acclimated buds of Dracocephalum austriacum (Lamiaceae) from field material
Authors: Rasl Thomas , Schalk Mona , Temsch Eva , Kodym Andrea 
Published: May 2020

AbstractThis study develops protocols for the micropropagation and cryopreservation of Dracocephalum austriacum (Lamiaceae). It is a perennial herbaceous plant that overwinters with ground-level sprouts and is classified as critically endangered in Europe. In vitro cultures were initiated from seeds on growth-regulator-free Murashige & Skoog (MS) medium after nicking the seed coat. Propagation via shoot culture was achieved on ½ MS medium with 1 µM benzyl adenine (BAP). Rooting on various indole-3-butyric acid (IBA)-media was not reliable, but the rooting success was 80% after 10 weeks on medium with 1 µM BAP. Two starting materials underwent cryopreservation: (1) shoot tips from cold-acclimated in vitro plantlets and (2) axillary buds from winter shoots from field plants. For the cryopreservation of in vitro shoots, plant vitrification solution (PVS)3 and incubation over ice yielded the best results (~ 34% regeneration success). However, regeneration using winter acclimated buds were 100, 76 and 30% for collections in December, February and March, respectively, using the same protocol. Moreover, the ploidy levels of cryopreserved plantlets were estimated using flow cytometry. The use of winter-acclimated field material of temperate herbaceous plants or subshrubs has high potential as explant source for cryopreservation and calls for exploring this technique for other species.
Effective skeleton stress and void ratio for constitutive modeling of fiber-reinforced sand
Authors: Gao Zhiwei , Lu Dechun , Huang Mian 
Published: May 2020

AbstractInclusion of flexible fibers such as polypropylene and polyester is an effective method for soil improvement, as it significantly enhances the soil strength and ductility. A proper constitutive model is essential for assessing the stability and serviceability of fiber-reinforced slopes/foundations. A new method for constitutive modeling of fiber-reinforced sand (FRS) is proposed. It assumes that the strain of FRS is dependent on the deformation of the sand skeleton only, while the effective skeleton stress and effective skeleton void ratio, which should be used in describing the dilatancy, plastic hardening and elastic stiffness of FRS, are affected by fiber inclusion. The effective skeleton stress is dependent on the shear strain level, and the effective skeleton void ratio is affected by the fiber content and sample preparation method. A critical state FRS model in the triaxial stress space is proposed using the concept of effective skeleton stress and void ratio. Four parameters are introduced to characterize the effect of fiber inclusion on the mechanical behavior of sand, all of which can be easily determined based on triaxial test data on FRS, without measuring the stress–strain relationship of individual fibers. The model is validated by triaxial compression test results on four fiber-reinforced sands under loading conditions with various confining pressures, densities and stress paths. Potential improvement in the model for incorporating fiber orientation anisotropy is discussed.
General and Alcohol-Related Social Media Use and Mental Health: a Large-Sample Longitudinal Study
Authors: Erevik Eilin K. , Pallesen Ståle , Vedaa Øystein , Andreassen Cecilie S. , Dhir Amandeep , Torsheim Torbjørn 
Published: May 2020

AbstractThe current study aimed to investigate if general and alcohol-related social media use predicts symptoms of depression and anxiety. Students in Bergen, Norway, participated in a Web-based survey during fall 2015 (T1) and a follow-up survey during fall 2016 (T2). A total of 5217 participated in both surveys. Crude and adjusted linear regression analyses were conducted to investigate if social media use at T1 predicted depression and anxiety at T2. Several social media use variables (e.g., using Instagram) were positively associated with depression and anxiety over time, but these associations became non-significant when covariates were controlled for. Number of online friends was inversely related to depression whereas using Twitter was positively related to anxiety at T2, when covariates were controlled for. The effect sizes of the observed associations were all very small. The current study found little support for a relationship between social media use and mental health.
Instantaneous mental workload assessment using time–frequency analysis and semi-supervised learning
Authors: Zhang Jianhua , Li Jianrong , Wang Rubin 
Published: May 2020

AbstractThe real-time assessment of mental workload (MWL) is critical for development of intelligent human–machine cooperative systems in various safety–critical applications. Although data-driven machine learning (ML) approach has shown promise in MWL recognition, there is still difficulty in acquiring a sufficient number of labeled data to train the ML models. This paper proposes a semi-supervised extreme learning machine (SS-ELM) algorithm for MWL pattern classification requiring only a small number of labeled data. The measured data analysis results show that the proposed SS-ELM paradigm can effectively improve the accuracy and efficiency of MWL classification and thus provide a competitive ML approach to utilizing a large number of unlabeled data which are available in many real-world applications.
Berufliche Aspirationen im Kontext regionaler Berufsstrukturen
Authors: Flohr Matthias , Menze Laura , Protsch Paula 
Published: May 2020

ZusammenfassungJugendliche entwickeln ihre beruflichen Pläne und Erwartungen in Interaktion mit signifikanten Anderen in den sozialen Kontexten, in denen sie sich bewegen. Innerhalb gleicher institutioneller Gelegenheitsstrukturen sind regionale Arbeitsmärkte wichtige sozialräumliche Kontexte, die über das unmittelbare Umfeld der Familie, der Schule oder der Nachbarschaft hinaus die Entwicklung von beruflichen Aspirationen bedingen. In unserem Beitrag untersuchen wir die Relevanz der regionalen Berufsstruktur, d. h. der Präsenz von unterschiedlichen Berufen auf dem regionalen Arbeitsmarkt, für die Berufswahl von nichtstudienberechtigten Jugendlichen in Deutschland. Unsere Ergebnisse basieren auf Daten der Startkohorte 4 des Nationalen Bildungspanels, die wir um beruflich-regionale Indikatoren auf Grundlage administrativer Statistiken der Bundesagentur für Arbeit ergänzen. Anhand von konditionalen logistischen Regressionsmodellen zeigen wir, dass sich die Jugendlichen in ihren beruflichen Aspirationen am Ende der Schulzeit an den Berufen der Erwerbstätigen in ihrer Region orientieren: Je höher der Anteil eines Berufs an der regionalen Berufsstruktur ist, desto wahrscheinlicher ist es, dass Jugendliche diesen Beruf aspirieren. Dieser Zusammenhang wird nicht über das berufliche Prestige oder die Geschlechterkomposition des Berufs moderiert. Unser Beitrag macht somit deutlich, dass die Wahl eines Berufs – und damit auch die mit dieser Wahl einhergehenden ungleichen längerfristigen Erwerbs- und Lebensbedingungen – zu einem gewissen Grad „per Lotterie“ über den Wohnort im Jugendalter bestimmt werden.
Die Rolle der Kontrolle in Organisationen: Konzeptionen und Nutzenaspekte eines facettenreichen Begriffs
Authors: Hensen Peter 
Published: May 2020

ZusammenfassungDieser Beitrag in der Zeitschrift Gruppe. Interaktion. Organisation (GIO) untersucht die funktionale Bedeutung von Kontrolle in Organisationen und arbeitet Nutzenaspekte für die Organisations- und Unternehmenspraxis heraus. Kontrolle als Begriff ist facettenreich. Er steht in enger Beziehung zu Macht und Handlung. Dazu gehören feststellende, reaktive und evaluative Tätigkeiten, die verallgemeinernd das Ziel verfolgen, ein Betriebs- und Organisationsgeschehen zu stabilisieren und zu optimieren. Konzipiert als technische Funktion dient Kontrolle der Erfüllung von Sachaufgaben; als Managementfunktion der Beherrschung von Unternehmensvorgängen. In einem konstruktivistischen Sinne erfüllt sie eine soziale Funktion des Gestaltens von Gemeinschaft. Kontrolle ist aber nicht nur sachbezogen zur Durchsetzung betrieblicher Interessen begründbar. Sie erfüllt darüber hinaus auch subjektive Nutzenfunktionen, die im wissenschaftlichen Diskurs und in der Organisationspraxis stärker betont werden sollten.
Nitrogen availability regulates deep soil priming effect by changing microbial metabolic efficiency in a subtropical forest
Authors: Liao Chang , Tian Qiuxiang , Liu Feng 
Published: May 2020

AbstractIn terrestrial ecosystems, deep soils (below 30 cm) are major organic carbon (C) pools. The labile carbon input could alter soil organic carbon (SOC) mineralization, resulting in priming effect (PE), which could be modified by nitrogen (N) availability, however, the underlying mechanism is unclear for deep soils, which complicates the prediction of deep soil C cycling in response to N deposition. A series of N applications with 13C labeled glucose was set to investigate the effect of labile C and N on deep SOC mineralization. Microbial biomass, functional community, metabolic efficiency and enzyme activities were examined for their effects on SOC mineralization and PE. During incubation, glucose addition promoted SOC mineralization, resulting in positive PE. The magnitude of PE decreased significantly with increasing N. The N-regulated PE was not dependent on extracellular enzyme activities but was positively correlated with carbon use efficiency and negatively with metabolic quotient. Higher N levels resulted in higher microbial biomass and SOC-derived microbial biomass than lower N levels. These results suggest that the decline in the PE under high N availability was mainly controlled by higher microbial metabolic efficiency which allocated more C for growth. Structural equation modelling also revealed that microbial metabolic efficiency rather than enzyme activities was the main factor regulating the PE. The negative effect of additional N suggests that future N deposition could promote soil C sequestration.
Differences in guideline-recommended heart failure medication between Dutch heart failure clinics: an analysis of the CHECK-HF registry
Authors:   CHECK-HF investigators, Linssen G. C. M. , Veenis J. F. , Brunner-La Rocca H. P. , van Pol P. E. J. , Engelen D. J. M. , van Tooren R. M. , Koornstra-Wortel H. J. J. , Hoes A. W. , Brugts J. J. 
Published: May 2020

Abstract
Background
Heart failure (HF) is associated with poor prognosis, high morbidity and mortality. The prognosis can be optimised by guideline adherence, which also can be used as a benchmark of quality of care. The purpose of this study was to evaluate differences in use of HF medication between Dutch HF clinics.

Methods
The current analysis was part of a cross-sectional registry of 10,910 chronic HF patients at 34 Dutch outpatient clinics in the period of 2013 until 2016 (CHECK-HF), and focused on the differences in prescription rates between the participating clinics in patients with heart failure with reduced ejection fraction (HFrEF).

Results
A total of 8,360 HFrEF patients were included with a mean age of 72.3 ± 11.8 years (ranging between 69.1 ± 11.9 and 76.6 ± 10.0 between the clinics), 63.9% were men (ranging between 54.3 and 78.1%), 27.3% were in New York Heart Association (NYHA) class III/IV (ranging between 8.8 and 62.1%) and the average estimated glomerular filtration rate (eGFR) was 59.6 ± 24.6 ml/min (ranging between 45.7 ± 23.5 and 97.1 ± 16.5).
The prescription rates ranged from 58.9–97.4% for beta blockers (p < 0.01), 61.9–97.1% for renin-angiotensin system (RAS) inhibitors (p < 0.01), 29.9–86.8% for mineralocorticoid receptor antagonists (MRAs) (p < 0.01), 0.0–31.3% for ivabradine (p < 0.01) and 64.9–100.0% for diuretics (p < 0.01). Also, the percentage of patients who received the target dose differed significantly, 5.9–29.1% for beta blockers (p < 0.01), 18.4–56.1% for RAS inhibitors (p < 0.01) and 13.2–60.6% for MRAs (p < 0.01).

Conclusions
The prescription rates and prescribed dosages of guideline-recommended medication differed significantly between HF outpatient clinics in the Netherlands, not fully explained by differences in patient profiles.
Young Adulthood Relationships in an Era of Uncertainty: A Case for Cohabitation
Authors: Manning Wendy D. 
Published: May 2020

AbstractThe young adulthood years are demographically dense. Dr. Ronald Rindfuss made this claim when he was Population Association of America (PAA) president in 1991 (Rindfuss 1991), and this conclusion holds today. I offer both an update of his work by including Millennials and a new view on young adulthood by focusing on an increasingly common experience: cohabitation. I believe we need to move away from our marriage-centric lens of young adulthood and embrace the complexity that cohabitation offers. The cohabitation boom is continuing with no evidence of a slowdown. Young adults are experiencing complex relationship biographies, and social science research is struggling to keep pace. Increasingly, there is a decoupling of cohabitation and marriage, suggesting new ways of framing our understanding of relationships in young adulthood. As a field, we can do better to ensure that our theories, methods, and data collections better reflect the new relationship reality faced by young adults.
Evacuees and Migrants Exhibit Different Migration Systems After the Great East Japan Earthquake and Tsunami
Authors: Hauer Mathew E. , Holloway Steven R. , Oda Takashi 
Published: May 2020

Abstract
Research on the destinations of environmentally induced migrants has found simultaneous migration to both nearby and long-distance destinations, most likely caused by the comingling of evacuee and permanent migrant data. Using a unique data set of separate evacuee and migration destinations, we compare and contrast the pre-, peri-, and post-disaster migration systems of permanent migrants and temporary evacuees of the Great East Japan Earthquake and Tsunami. We construct and compare prefecture-to-prefecture migration matrices for Japanese prefectures to investigate the similarity of migration systems. We find evidence supporting the presence of two separate migration systems—one for evacuees, who seem to emphasize short distance migration, and one for more permanent migrants, who emphasize migration to destinations with preexisting ties. Additionally, our results show that permanent migration in the peri- and post-periods is largely identical to the preexisting migration system. Our results demonstrate stability in migration systems concerning migration after a major environmental event.