bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microstructural and ageing response assessment of eutectic Al-Cu alloy due to isothermal heat treatment in semisolid state
Authors: Chaudhari Abhimanyu , Nasker Purnendu , Srivastava Ankur , Paul Sudeep , Chakrabarti Ajit Kumar 
Published: December 2019

Abstract
An as cast Al-33%Cu eutectic alloy has been processed by semisolid heat treatment, with the ultimate objective of developing a ductile and strong eutectic composite material for probable application as bearing materials and other sliding wear components. In this phase of work only microstructural characterises has been attempted. The as cast sample of Al–Cu alloy is subjected to isothermal heat treatment at a temperature of 560 °C for varying periods of time and followed by water quenched. The microstructures of the semisolid heat treated (SSH) samples are analysed using an optical microscope and scanning electron microscopy (SEM). The microstructures of the quenched Al-33%Cu alloy samples show lamellar to lamellar + dendritic transition after SSH treatment. The quenched microstructure after 20 min of holding time primarily consists of copper aluminide dendrites + supersaturated α–Al grains. A massive copper-aluminide (>80%Cu) intermediate phase is observed after 3 to 6 min SSH. The sample configuration did not change after semisolid heat treatment and water quenching. This suggest that complete remelting and overburning did not occur during the semisolid heat treatment. The SSH sample shows maximum hardness, after 10 min holding time compared to solution treated (at 560 °C) and aged (at 150 °C) sample of a standard Al-4.5%Cu cast alloy. The Transmission electron microscopy (TEM) micrograph of the as quenched 10 min. SSH sample shows rod shaped CuAl2 (θ) precipitates, a dislocation network, cellular subgrains and an extremely fine lamellar eutectic. Solute cluster probably Guinier–Preston (GP) zones, precipitates and fine α –Al grains was observed in the peak aged sample. The x-ray diffraction (XRD) analysis of aged SSH treated sample shows several intermetallic copper-aluminide phases in each sample.
Aphids in focus: unravelling their complex ecology and evolution using genetic and molecular approaches
Authors: Loxdale Hugh D , Balog Adalbert , Biron David G 
Published: December 2019

AbstractAphids are renowned plant parasites of agriculture, horticulture and forestry, causing direct physical damage by sucking phloem and especially by transmission of plant pathogenic viruses. The huge yield loss they cause amounts to hundreds of millions of dollars globally, and because of this damage and the intense efforts expended on control, some 20 species are now resistant to pesticides worldwide. Aphids represent an ancient, mainly northern temperate group, although some species occur in the tropics, often as obligate asexual lineages or even asexual ‘species’. However, besides their notoriety as enemies of plant growers, aphids are also extremely interesting scientifically, especially at the molecular and genetic levels. They reproduce mainly asexually, one female producing 10–90 offspring in 7–10 days and therefore, theoretically, could produce billions of offspring in one growing season in the absence of mortality factors (i.e. climate/weather and antagonists). In this overview, we provide examples of what molecular and genetic studies of aphids have revealed concerning a range of topics, especially fine-grained ecological processes. Aphids, despite their apparently limited behavioural repertoire, are in fact masters (or, perhaps more accurately, mistresses) of adaptation and evolutionary flexibility and continue to flourish in a variety of ecosystems, including the agro-ecosystem, regardless of our best efforts to combat them.
Cancer incidence and risk factors in dialysis patients with human immunodeficiency virus: a cohort study
Authors: Patel Mihir , Waller Jennifer L , Baer Stephanie L , Spearman Vanessa , Kheda Mufaddal , Young Lufei , Nahman Stan , Colombo Rhonda E 
Published: December 2019

Abstract

Background
Patients with human immunodeficiency virus (HIV) or end-stage renal disease receiving dialysis have an increased risk of developing malignancies, but few data are available on cancer in patients with both conditions. Thus, the objective of this study was to determine the incidence of selected malignancies and identify their potential risk factors in HIV-infected dialysis patients.

Methods
This study was a nationwide cohort analysis using the US Renal Data System. Participants included all HIV-infected patients starting dialysis from 2005 to 2011. HIV status, comorbidities and malignancies were identified using International Classification of Diseases, Ninth Revision codes. Descriptive statistics and generalized linear models quantifying risk factors were performed for the overall cohort and the three most common malignancies.

Results
Overall, 6641 HIV-infected dialysis patients were identified, with 543 (8.2%) carrying a malignancy diagnosis. The most common malignancies were non-Hodgkin’s lymphoma (NHL, 25%), Kaposi sarcoma (KS, 16%) and colorectal cancer (13%). Factors increasing the risk of any malignancy diagnosis included: history of cancer [adjusted relative risk (aRR) = 5.37], two or more acquired immunodeficiency syndrome-defining opportunistic infections (ADOIs) (aRR = 3.11), one ADOI (aRR = 2.23), cirrhosis (aRR = 2.20), male sex (aRR = 1.54) and hepatitis B (aRR = 1.52). For NHL and colorectal cancer, history of cancer (aRR = 7.05 and 9.80, respectively) was the most significant risk factor. For KS, two or more ADOIs (aRR = 6.78) was the largest risk factor.

Conclusions
Over 8% of HIV-infected dialysis patients developed a malignancy. History of cancer and ADOIs were major risk factors, underscoring the significance of immune dysregulation in malignancy development.
Meso-tartrate inhibits intracellular replication of Coxiella burnetii, the causative agent of the zoonotic disease Q fever
Authors: Bitew Mebratu A , Wawegama Nadeeka K , Newton Hayley J , Sansom Fiona M 
Published: December 2019

ABSTRACT
The zoonotic disease Q fever caused by the intracellular bacterium Coxiella burnetii remains a global health threat due to its high infectivity, environmental stability, the debilitating nature and the long duration of treatment. Designing new and potent drugs that target previously unexplored pathways is essential to shorten treatment time and minimise antibiotic resistance. Nicotinamide adenine dinucleotide (NAD) is an essential and ubiquitous cofactor in all living organisms. NadB, an L-aspartate oxidase catalysing the first step of the prokaryotic-specific NAD de novo biosynthetic pathway, is required for C. burnetii growth and replication inside host cells. In this study, in vitro enzyme assays utilising recombinant glutathione S-transferase tagged NadB (GST-NadB) demonstrated inhibition of the L-aspartate oxidase activity of NadB by meso-tartrate. Furthermore, meso-tartrate inhibits intracellular growth and replication of C. burnetii inside host cells in a dose-dependent manner, and has no effect on the viability of mammalian cells. Unexpectedly, meso-tartrate also inhibited growth of C. burnetii in axenic medium, and further reduces replication of the nadB mutant inside host cells, suggesting it is acting more widely than simple inhibition of NadB. Overall, these results suggest that the antibacterial activity of meso-tartrate warrants further study, including investigation of its additional target(s).
Using a custom mobile application for change management in an electronic health record implementation
Authors: Threatt Tony , Pirtle Claude J , Dzwonkowski Jennifer , Johnson Kevin B 
Published: December 2019

Abstract

Objectives
Institutions cite managing the modification in infrastructure, technical support, and process change as substantial barriers to a successful electronic health record (EHR) implementation. In an effort to organize and centralize the complex scheduling, task completion and communication needs of a “big-bang” EHR go-live, we developed a unified communication system with the goal of improving implementation process efficiency. Our goal was to create a platform that would work across the medical enterprise.

Materials and Methods
We employed an agile process to design the application, called Hubbl, based on initial requirements and iteratively obtained stakeholder user. The final feature set included role-specific organization, integrated communication, task and content management tooling, and embedded project information retrieval, all embedded into the end user’s day to day activities.

Results
User enrollment continually increased from launch in February of 2017 through go-live day. During the pre-go-live period, usage increased from an average of 7.37 events/user/day to 18.65 events/user/day with over 97 communications sent across all periods. 5400 unique users accessed tip sheets and information retrieval tools averaged 28.84 searches/user/day during the go-live period with an average high of 46.33 searches/user/day 5 days post-go-live. User access during go-live and post-go-live averaged 12.82 accesses/user/day and decreased from 20.42 average accesses on day one of go live to 14.07 averaged accesses on day 60 of post-go-live with over 727 tasks monitored to completion during all periods.

Conclusion
Hubbl was an essential component of our communication, task coordination, and change management strategy, for our EHR go live. Institutions that choose a unified mobile and web-based platform during a substantial IT (information technology) implementation can feasibly ensure task completion, project coordination, and timely information dissemination.
Why Won’t You Answer the Question? Mass-Mediated Deception Detection After Journalists’ Accusations of Politicians’ Evasion
Authors: Clementson David E 
Published: December 2019

Abstract
Journalists often accuse politicians of dodging questions. Truth-default theory (TDT) predicts that when journalists serve as de facto deception detectors, the audience will process the messaging through a cognitive sequence that lowers the perceived trustworthiness of the politician. Conversely, the public’s perception of the media as being generally hostile and biased in their reporting could make a journalist’s allegation of evasion enhance the politician’s credibility. We constructed political TV interviews in which a journalist falsely accused a politician of evasiveness. Consistent with serial multiple mediation as proposed by TDT, in Study 1 (N = 210 U.S. voters) a journalist’s allegation triggered suspicion, which increased perceived dodging, resulting in voters distrusting the politician. Absent a journalist’s allegation, however, people remained in their truth-default state toward the politician. Study 2 (N = 429) replicated the Study 1 results, and conditional process modeling revealed that the effect was moderated by rumination.
Association mapping and genetic dissection of drought-induced canopy temperature differences in rice
Authors: Melandri Giovanni , Prashar Ankush , McCouch Susan R , van der Linden Gerard , Jones Hamlyn G , Kadam Niteen , Jagadish Krishna , Bouwmeester Harro , Ruyter-Spira Carolien 
Published: December 2019

Abstract
Drought-stressed plants display reduced stomatal conductance, which results in increased leaf temperature by limiting transpiration. In this study, thermal imaging was used to quantify the differences in canopy temperature under drought in a rice diversity panel consisting of 293 indica accessions. The population was grown under paddy field conditions and drought stress was imposed for 2 weeks at flowering. The canopy temperature of the accessions during stress negatively correlated with grain yield (r= –0.48) and positively with plant height (r=0.56). Temperature values were used to perform a genome-wide association (GWA) analysis using a 45K single nucleotide polynmorphism (SNP) map. A quantitative trait locus (QTL) for canopy temperature under drought was detected on chromosome 3 and fine-mapped using a high-density imputed SNP map. The candidate genes underlying the QTL point towards differences in the regulation of guard cell solute intake for stomatal opening as the possible source of temperature variation. Genetic variation for the significant markers of the QTL was present only within the tall, low-yielding landraces adapted to drought-prone environments. The absence of variation in the shorter genotypes, which showed lower leaf temperature and higher grain yield, suggests that breeding for high grain yield in rice under paddy conditions has reduced genetic variation for stomatal response under drought.
Spectral characterization of the non-thermal X-ray emission of gamma-ray pulsars
Authors: Coti Zelati Francesco , Torres Diego F , Li Jian , Viganò Daniele 
Published: December 2019

ABSTRACT
We report on a detailed spectral characterization of the non-thermal X-ray emission for a large sample of gamma-ray pulsars in the second Fermi Large Area Telescope catalogue. We outline the criteria adopted for the selection of our sample, its completeness, and critically describe different approaches to estimate the spectral shape and flux of pulsars. We perform a systematic modelling of the pulsars’ X-ray spectra using archival observations with XMM–Newton, Chandra, and NuSTAR and extract the corresponding non-thermal X-ray spectral distributions. This set of data is made available online and is useful to confront with predictions of theoretical models.
Chemical abundances of Seyfert 2 AGNs – I. Comparing oxygen abundances from distinct methods using SDSS
Authors: Dors O L , Freitas-Lemes P , Amôres E B , Pérez-Montero E , Cardaci M V , Hägele G F , Armah M , Krabbe A C , Faúndez-Abans M 
Published: December 2019

ABSTRACT
We compare the oxygen abundance (O/H) of the narrow-line regions (NLRs) of Seyfert 2 AGNs obtained through strong-line methods and from direct measurements of the electron temperature (Te-method). The aim of this study is to explore the effects of the use of distinct methods on the range of metallicity and on the mass–metallicity relation of active galactic nuclei (AGNs) at low redshifts (z ≲ 0.4). We used the Sloan Digital Sky Survey (SDSS) and NASA/IPAC Extragalactic Database (NED) to selected optical (3000 &lt; λ(Å) &lt; 7000) emission line intensities of 463 confirmed Seyfert 2 AGNs. The oxygen abundances of the NLRs were estimated using the theoretical Storchi-Bergmann et al. calibrations, the semi-empirical N2O2 calibration, the Bayesian H  ii-Chi-mistry code and the Te-method. We found that the oxygen abundance estimations via the strong-line methods differ from each other up to ∼0.8 dex, with the largest discrepancies in the low-metallicity regime ($\rm 12+\log (O/H) \: \lesssim \: 8.5$). We confirmed that the Te-method underestimates the oxygen abundance in NLRs, producing unreal subsolar values. We did not find any correlation between the stellar mass of the host galaxies and the metallicity of their AGNs. This result is independent of the method used to estimate Z.
Long-term safety and efficacy of sodium zirconium cyclosilicate for hyperkalaemia in patients with mild/moderate versus severe/end-stage chronic kidney disease: comparative results from an open-label, Phase 3 study
Authors: Roger Simon D , Lavin Philip T , Lerma Edgar V , McCullough Peter A , Butler Javed , Spinowitz Bruce S , von Haehling Stephan , Kosiborod Mikhail , Zhao June , Fishbane Steven , Packham David K 
Published: December 2019

AbstractBackgroundSodium zirconium cyclosilicate (SZC; formerly ZS-9) is a selective potassium (K+) binder for the treatment of adults with hyperkalaemia. This post hoc analysis of an open-label, single-arm trial (NCT02163499) compared SZC efficacy and safety &gt;12 months among outpatients with hyperkalaemia and Stages 4 and 5 chronic kidney disease (CKD) versus those with Stages 1–3 CKD.MethodsAdults with serum K+ ≥5.1 mmol/L (measured by point-of-care i-STAT device) received SZC 10 g three times daily for 24–72 h until normokalaemia (i-STAT K+ 3.5–5.0 mmol/L) was achieved [correction phase (CP)], followed by once daily SZC 5 g for ≤12 months [maintenance phase (MP)]. Here, patients were stratified by baseline estimated glomerular filtration rate (eGFR &lt;30 or ≥30 mL/min/1.73 m2). Study endpoints included percent achieving normokalaemia during CP and MP, mean serum K+ and bicarbonate during MP, and adverse events (AEs).ResultsOf 751 patients enrolled, 289 (39%), 453 (60%) and 9 (1%) had baseline eGFR values of &lt;30, ≥30 mL/min/1.73 m2 or missing, respectively. During the CP, 82% of patients achieved normokalaemia in both eGFR subgroups within 24 h, and 100 and 95% with baseline eGFR &lt;30 and ≥30 mL/min/1.73 m2, respectively, within 72 h. Corresponding proportions with normokalaemia during the MP were 82 and 90% at Day 365, respectively. Mean serum K+ reduction from baseline during the CP was sustained throughout the MP and serum bicarbonate increased. AEs during the MP were more common in the eGFR &lt;30 ≥30 mL/min/1.73 m2 subgroup.ConclusionsSZC corrects hyperkalaemia and maintains normokalaemia among outpatients regardless of the CKD stage.
LS1 PRACTICAL APPLICATION AND UNDERLYING BIOLOGY OF TUMOR TREATING FIELDS
Authors: Bota Daniela 
Published: December 2019

Abstract
Glioblastoma (GBM) is the most common and most aggressive form of brain cancer in adults. For decades, the mainstay of therapeutic intervention was based on surgical resection (when safely feasible), followed by radiotherapy (RT). In 2005, data from the landmark EORTC-NCIC trial changed the standard of care treatment for GBM. This phase III trial demonstrated a survival advantage for concomitant and adjuvant temozolomide (TMZ) chemotherapy when added to the standard course of radiation. In the group of patients assigned to radiation plus TMZ, median survival improved from 12.1 months (radiotherapy alone) to 14.6 months, but all the patient finally relapsed on TMZ. In 2015, Tumor Treating Fields (TTF, Optune) became the first FDA-approved device for the treatment of for newly diagnosed GBM. This approval was based on the EF-14 clinical trial results, in which nearly half of the patients treated with Optune in combination with maintenance temozolomide (TMZ) were alive at 2 years compared with 31% of people on TMZ alone.
Optune utilize the natural electrical properties of dividing cancer cells to disrupt mitosis and provide continuous antimitotic action against progression of GBM. TTF-treated tumor cells can exit the process of mitosis aberrantly and release cellular stress signals, such as the endoplasmic reticulum chaperonin calreticulin (CRT) and high mobility group box 1 protein (HMGB1). CRT is important to induce antitumor immune responses because CRT inhibition decreases immunogenicity. HMGB1, an endogenous chromatin-associated protein released from dying tumor cells, also plays a critical role in the activation of HMGB1-mediated toll-like receptor 2 (TLR2) immune signaling. The presence of those signals may facilitate immune activation, and immunogenic induced cell death, and eventually result in tumor destruction.
In this presentation, Daniela Bota, MD, PhD, will review the clinical results of Optune in the treatment of GBM, and will discuss the novel biological mechanisms underlying the effects of Optune in controlling tumor growth and promoting the immune responses in GBM.
LS2 METASTATIC BRAIN TUMORS / MENINGIOMAS: CURRENT CONCEPTS AND THERAPEUTIC PERSPECTIVES
Authors: Preusser Matthias 
Published: December 2019

Abstract
Non-glial brain tumors are the most common neoplasms affecting the central nervous system. Brain metastases are a heterogenous complication of systemic cancers. Recent research has provided insight into some important aspects of brain metastasis development, interaction of brain-metastatic tumor cells with resident cells of the CNS microenvironment and growth patterns within the brain parenchyma.Treatment choices have to consider clinical presentation, number, size and localisation of brain metastases, status of extracranial tumor burden, prior therapies, co-morbidities and histological and molecular tumor characteristics. Recent advances show that targeted therapies and immunotherapies have activity against established brain metastases and some targeted therapies are able to prevent brain metastasis development. Meningiomas are common and can be cured in 70–80% of cases by surgical resection. However, the rest of cases cannot be resected completey due to surgically inaccessibility (e.g. skull base) or show non-benign histopathological features that are associated with tumor recurrence. Meningiomas have been shown to be molecularly variable and carry distinct and reccurent genetic and epigenetic alterations that seem to enable targeted therapy and refined prognostication. Overall, significant advances in the biologcial understanding of brain metastases and meningiomas drive clinical trial design and improvement of clinical management strategies for these common tumors.
MS3-2 TREATMENT STRATEGY BASED ON THE RESULTS OF GENE PANELS
Authors: Takeda Masayuki 
Published: December 2019

Abstract
The advance of next-generation sequencers (NGS) has dramatically improved the performance of genomic analysis of clinical samples in cancer precision medicine. The practical use of gene panel testing for clinical applications has begun in Japan. At present, “OncomineTM Dx Target Test” is listed as a companion diagnostic system using NGS, and “FoundationOne CDx Cancer Genomic Profile” and “OncoGuide™ NCC Oncopanel System” are listed as gene panel testing under insurance coverage. Formalin-fixed paraffin-embedded specimen have been routinely used for molecular diagnosis testing, therefore quality control such as formalin fixation time and tumor contents is important to ensure validity of diagnostic results. In this presentation, the issue to obtain evaluable results of gene panel testing using formalin-fixed paraffin-embedded specimen will be discussed.
Due to evolution of detection technologies, we can detect gene mutation with high sensitivity. Detection of gene mutation in circulating tumor DNA is feasible approach for diagnostic testing in cancer treatment. Liquid biopsy has been approved as a companion diagnostic testing to detect EGFR mutations in NSCLC. Examples of the clinical utility of plasma testing in cancer treatment will be presented.