bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of a High-Intensity Exercise Program on Weight Regain and Cardio-metabolic Profile after 3 Years of Bariatric Surgery: A Randomized Trial
Authors: Marc-Hernández A. , Ruiz-Tovar J. , Aracil A. , Guillén S. , Moya-Ramón M. 
Published: February 2020

AbstractWeight regain is one of the most common problems in the long-term after bariatric surgery. It is unknown if high-intensity exercise programs applied in late phases of post-surgical follow-up could counteract this trend. After a 3-year follow-up, 21 patients underwent sleeve gastrectomy were randomized into an exercise group (EG, n = 11), that performed a 5-month supervised exercise program, and a control group (CG, n = 10), that followed the usual care. Body composition, cardiorespiratory fitness, glycaemia and blood cholesterol were evaluated before and after the intervention. Finally, the EG repeated the evaluations 2 months after the end of the exercise program. Both groups reached their maximum weight loss at the first year after surgery and showed significant weight regain by the end of the follow-up. After the exercise program, the EG showed reductions in fat mass (−2.5 ± 2.6  kg, P < 0.05), glycaemia (−13.4 ± 8.7  mg·dL−1,P < 0.01) and blood cholesterol (−24.6 ± 29.1  mg·dL−1, P < 0.05), whereas the CG during the same period showed increases in weight (1.5 ± 1.3  kg, P < 0.05) and fat mass (1.8 ± 0.9, P < 0.01). Two months after the end of the program, EG had increases in weight (1.1 ± 1.2  kg, P < 0.05), fat mass (2.6 ± 2.2  kg, P < 0.01), glycaemia (8.2 ± 11.6  mg·dL−1, P < 0.05) and blood cholesterol (20.0 ± 22.1  mg·dL−1, P < 0.05), when compared with the values after the exercise program. Therefore, in the medium-term after sleeve gastrectomy exercise may contribute to prevent weight regain and to reduce fat mass, glycaemia, and blood cholesterol.
Anterior cruciate ligament remnant cells have different potentials for cell differentiation based on their location
Authors: Lee Jin Kyu , Jo Sungsin , Lee Young Lim , Park Hyosun , Song Jun-Seob , Sung Il-Hoon , Kim Tae-Hwan 
Published: February 2020

AbstractHistological and cytological observations of the human anterior cruciate ligament (ACL) had been described, but the differentiation potency based on their location is still unknown. To determine and compare proliferation and differentiation potential of cells derived from distal and middle thirds of the ACL remnant, ACL remnant was initially marked at the distal third (within 10  mm from the tibial insertion) and middle third (between 10–20  mm from the tibial insertion) and then dissected. Both the middle and distal third regions of ACL remnant were analyzed using CD34+ cell counting. Cell proliferation rate did not differ in both middle and distal third regions of ACL remnant, but they showed different characteristics in cell differentiation depending on their location. The distal third region of the ACL remnant had a tendency for chondrogenic differentiation with higher expression of CD34+ cells. On the other hand, the middle third region of ACL remnant had a strong tendency for osteogenic and ligamentous differentiation. Characteristics of the ACL remnant tissues should be considered when performing remnant-preserving or harvesting ACL remnants for tissue engineering.
Histone demethylase KDM4D cooperates with NFIB and MLL1 complex to regulate adipogenic differentiation of C3H10T1/2 mesenchymal stem cells
Authors: Choi Jang Hyun , Lee Hansol 
Published: February 2020

AbstractThe coordinated and sequential actions of lineage-specific transcription factors and epigenetic regulators are essential for the initiation and maintenance of cellular differentiation. We here report KDM4D histone demethylase as a key regulator of adipogenesis in C3H10T1/2 mesenchymal stem cells. The depletion of KDM4D results in impaired differentiation, which can be rescued by exogenous KDM4D, PPARγ, and C/EBPα, but not by C/EBPβ. In addition, KDM4D interacts physically and functionally with both NFIB and MLL1 complex to regulate C/EBPα and PPARγ expression upon adipogenic hormonal induction. Although KDM4D is dispensable for the binding of both NFIB and MLL1 complex to the target promoters, the demethylation of tri-methylated H3K9 by KDM4D is required for NFIB and MLL1 complex to deposit tri-methylated H3K4 and activate PPARγ and C/EBPα expression. Taken together, our data provide a molecular framework for lineage-specific transcription factor and histone modifiers to cooperate in adipogenic differentiation, in which KDM4D removes repressive histone marks at genes with a bivalent chromatin domain and allows NFIB and MLL1 complex to promote the expression of key adipogenic regulators.
Identification of networking quantum teleportation on 14-qubit IBM universal quantum computer
Authors: Huang Ni-Ni , Huang Wei-Hao , Li Che-Ming 
Published: February 2020

AbstractQuantum teleportation enables networking participants to move an unknown quantum state between the nodes of a quantum network, and hence constitutes an essential element in constructing large-sale quantum processors with a quantum modular architecture. Herein, we propose two protocols for teleporting qubits through an N-node quantum network in a highly-entangled box-cluster state or chain-type cluster state. The proposed protocols are systematically scalable to an arbitrary finite number N and applicable to arbitrary size of modules. The protocol based on a box-cluster state is implemented on a 14-qubit IBM quantum computer for N up to 12. To identify faithful networking teleportation, namely that the elements on real devices required for the networking teleportation process are all qualified for achieving teleportation task, we quantify quantum-mechanical processes using a generic classical-process model through which any classical strategies of mimicry of teleportation can be ruled out. From the viewpoint of achieving a genuinely quantum-mechanical process, the present work provides a novel toolbox consisting of the networking teleportation protocols and the criteria for identifying faithful teleportation for universal quantum computers with modular architectures and facilitates further improvements in the reliability of quantum-information processing.
The influence of attractor stability of intrinsic coordination patterns on the adaptation to new constraints
Authors: Yamamoto Kota , Shinya Masahiro , Kudo Kazutoshi 
Published: February 2020

AbstractIn most human movement tasks, the same goal can be achieved by a diversity of coordination patterns. For instance, when learning to juggle, individuals adopt their own unique coordination patterns in the early stages of acquiring the fundamental skills of juggling. These individual differences in the learning paths lead to differences in adaptability to new constraints. However, the reason for these differences in adaptability is still unknown. To address this problem, we quantified these differences in terms of attractor stability of the coordination patterns of expert jugglers using Recurrence Quantification Analysis. Furthermore, we quantified the attractor stability of intermediate jugglers and examined adaptability in a sensorimotor synchronization task. We found differences in attractor stability among coordination patterns of expert jugglers, as well as a difference in attractor stability between intrinsic coordination patterns of intermediate jugglers. Whereas, almost no significant direct correlation between attractor stability and adaptability of intermediate jugglers was found, suggesting a difference in both attractor stability and adaptability between intrinsic coordination patterns such that the difference in attractor stability might affect adaptability to new constraints. We submit that the learning path selected by each learner in the early stages of learning plays an important role in the subsequent development of expertise.
Assessment of adverse events related to anti-influenza neuraminidase inhibitors using the FDA adverse event reporting system and online patient reviews
Authors: Han Nayoung , Oh Jung Mi , Kim In-Wha 
Published: February 2020

AbstractThe recommended antiviral drugs available for the treatment and prevention of influenza are neuraminidase inhibitors (NAIs). The aim of this study was to evaluate age-related clinical manifestations of adverse events (AEs) related to NAIs. FAERS and WebMD data were downloaded. The available NAIs selected for the analysis were oseltamivir, peramivir, zanamivir, and laninamivir. Disproportionality was analyzed using the proportional reporting ratio (PRR), the reporting odds ratio (ROR), and the information component (IC) methods. In total, 16729 AEs from 4598 patients and 575 AEs from 440 patients in the FAERS and WebMD, respectively, were included in the analysis. In the FAERS, AEs were more common among those who were younger (<19 years) for zanamivir, while for those who were older (>65 years) for peramivir. A disproportionality analysis showed that signals for vomiting and hallucinations were detected in younger patients given oseltamivir, while an abnormal hepatic function, cardiac failure, shock, and cardio-respiratory arrest were detected in older patients given peramivir. Psychiatric disorders were most common in younger and older patients, while gastrointestinal disorders were most common in adult given oseltamivir in the WebMD. Adverse symptoms related to NAIs varied and depended on the drugs used and the age of the patient.
Assessment of a rapid diagnostic test to exclude bacteraemia and effect on clinical decision-making for antimicrobial therapy
Authors: Yui Samuel , Bercades Georgia , Muzslay Monika , Blackburn Emma , Ali Shanom , Smyth Deborah , Macklin Alison , Ryu Jung Hyun , Bassett Paul , MacCallum Niall , Brealey David , Wilson Peter 
Published: February 2020

AbstractUnnecessary antimicrobial treatment promotes the emergence of resistance. Early confirmation that a blood culture is negative could shorten antibiotic courses. The Cognitor Minus test, performed on blood culture samples after 12 hours incubation has a negative predictive value (NPV) of 99.5%. The aim of this study was to determine if earlier confirmation of negative blood culture result would shorten antibiotic treatment. Paired blood cultures were taken in the Critical Care Unit at a teaching hospital. The Cognitor Minus test was performed on one set >12 hours incubation but results kept blind. Clinicians were asked after 24 and 48 hours whether a result excluding bacteraemia or fungaemia would affect decisions to continue or stop antimicrobial treatment. Over 6 months, 125 patients were enrolled. The median time from start of incubation to Cognitor Minus test was 27.1 hours. When compared to 5 day blood culture results from both the control and test samples, Cognitor Minus gave NPVs of 99% and 100% respectively. Test results would have reduced antibiotic treatment in 14% (17/119) of patients at 24 and 48 hours (24% at either time) compared with routine blood culture. The availability of rapid tests to exclude bacteraemia may be of benefit in antimicrobial stewardship.
Mechanism underlying starvation-dependent modulation of olfactory behavior in Drosophila larva
Authors: Slankster Eryn , Kollala Sai , Baria Dominique , Dailey-Krempel Brianna , Jain Roshni , Odell Seth R. , Mathew Dennis 
Published: February 2020

AbstractStarvation enhances olfactory sensitivity that encourage animals to search for food. The molecular mechanisms that enable sensory neurons to remain flexible and adapt to a particular internal state remain poorly understood. Here, we study the roles of GABA and insulin signaling in starvation-dependent modulation of olfactory sensory neuron (OSN) function in the Drosophila larva. We show that GABAB-receptor and insulin-receptor play important roles during OSN modulation. Using an OSN-specific gene expression analysis, we explore downstream targets of insulin signaling in OSNs. Our results suggest that insulin and GABA signaling pathways interact within OSNs and modulate OSN function by impacting olfactory information processing. We further show that manipulating these signaling pathways specifically in the OSNs impact larval feeding behavior and its body weight. These results challenge the prevailing model of OSN modulation and highlight opportunities to better understand OSN modulation mechanisms and their relationship to animal physiology.
Action execution and action observation elicit mirror responses with the same temporal profile in human SII
Authors: Del Vecchio Maria , Caruana Fausto , Sartori Ivana , Pelliccia Veronica , Zauli Flavia Maria , Lo Russo Giorgio , Rizzolatti Giacomo , Avanzini Pietro 
Published: February 2020

AbstractThe properties of the secondary somatosensory area (SII) have been described by many studies in monkeys and humans. Recent studies on monkeys, however, showed that beyond somatosensory stimuli, SII responds to a wider number of stimuli, a finding requiring a revision that human SII is purely sensorimotor. By recording cortical activity with stereotactic electroencephalography (stereo-EEG), we examined the properties of SI and SII in response to a motor task requiring reaching, grasping and manipulation, as well as the observation of the same actions. Furthermore, we functionally characterized this area with a set of clinical tests, including tactile, acoustical, and visual stimuli. The results showed that only SII activates both during execution and observation with a common temporal profile, whereas SI response were limited to execution. Together with their peculiar response to tactile stimuli, we conclude that the role of SII is pivotal also in the observation of actions involving haptic control.
Connecting the Wilson depression to the magnetic field of sunspots
Authors: Löptien B. , Lagg A. , van Noort M. , Solanki S. K. 
Published: February 2020

Context. In sunspots, the geometric height of continuum optical depth unity is depressed compared to the quiet Sun. This so-called Wilson depression is caused by the Lorentz force of the strong magnetic field inside the spots. However, it is not understood in detail yet how the Wilson depression is related to the strength and geometry of the magnetic field or to other properties of the sunspot.
Aims. We aim to study the dependence of the Wilson depression on the properties of the magnetic field of the sunspots and how exactly the magnetic field contributes to balancing the Wilson depression with respect to the gas pressure of the surroundings of the spots.
Methods. Our study is based on 24 spectropolarimetric scans of 12 individual sunspots performed with Hinode. We derived the Wilson depression for each spot using both a recently developed method that is based on minimizing the divergence of the magnetic field and an approach that was developed earlier, which enforces an equilibrium between the gas pressure and the magnetic pressure inside the spot and the gas pressure in the quiet Sun, thus neglecting the influence of the curvature force. We then performed a statistical analysis by comparing the Wilson depression resulting from the two techniques with each other and by relating them to various parameters of the sunspots, such as their size or the strength of the magnetic field.
Results. We find that the Wilson depression becomes larger for spots with a stronger magnetic field, but not as much as one would expect from the increased magnetic pressure. This suggests that the curvature integral provides an important contribution to the Wilson depression, particularly for spots with a weak magnetic field. Our results indicate that the geometry of the magnetic field in the penumbra is different between spots with different strengths of the average umbral magnetic field.
Das polyzystische Ovarsyndrom: Aktuelle Evidenz und praktische Empfehlungen
Authors: Reger-Tan Susanne , Böing Christian , Führer-Sakel Dagmar 
Published: February 2020

AbstractPolycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in women of childbearing age. Due to hyperandrogenism and chronic anovulation affected women may suffer from hirsutism, androgenetic alopecia, acne, menstrual disturbance and sub-/infertility. Furthermore underlying insulin resistance promotes hyperandrogenemia, overweight and risk for diabetes. Therefore, routine evaluation of glycemic status is recommended. Treatment strategies are based on therapeutic lifestyle changes and focus on patient-important complaints. First line pharmacologic treatment for infertility in women with PCOS is letrozole. Clomiphene and metformin can be used alternatively with lower success rates. Women seeking medical advice for hyperandrogenism can be offered oral contraceptive pills with the lowest effective estrogen dose without any preference of a certain gestagen. Risk for deep vein thrombosis should be taken into account when choosing estrogen dose and type of gestagen. Antiandrogen substances such as spironolactone should only be prescribed in combination with safe contraception due to their risk of fetal undervirilisation. Additionally, substance specific risks should be considered. Baseline treatment of overweight or metabolic issues includes behaviour modification, weight reduction and physical activity. Additional benefit can be reached by combination of lifestyle changes with metformin. Studies indicate a positive effect of inositol and antidiabetic substances like liraglutide and empagliflozin but should be regarded as experimental therapies.
Stress-Echokardiografie
Authors: Hagendorff Andreas , Metze Michael , Neef Martin , Jurisch Daniel , Stöbe Stephan 
Published: February 2020

ZusammenfassungDie Stress-Echokardiografie ist wegen der verschiedenen Modalitäten (dynamische und pharmakologische Stress-Echokardiografie) eine komplexe Thematik. Bei der Auswahl der besten diagnostischen Möglichkeit spielen vor allem Schallbarkeit und Komorbiditäten des Patienten/der Patientin eine wesentliche Rolle. Für die Durchführung einer Stress-Echokardiografie müssen, neben einer adäquaten Ultraschall-Geräteausstattung, die technischen und personellen Anforderungen zur Behandlung von Akutkomplikationen bis hin zur Reanimation berücksichtigt werden. Der Untersucher muss in allen Bereichen der transthorakalen Echokardiografie ausgebildet sein und ein ausreichendes Training im Bereich der Stress-Echokardiografie absolviert haben. Dies umfasst Kenntnisse über Indikationen, Kontraindikationen und Abbruchkriterien einer Stress-Echokardiografie, die Bildakquisition unter erschwerten Bedingungen sowie die Optimierung und Auswertung des akquirierten Bildmaterials. Hauptindikationen stellen die Ischämie- und Vitalitätsdiagnostik dar, gefolgt von Indikationen zur spezifischen Abklärung von Kardiomyopathien und Herzklappenerkrankungen. Grundvoraussetzung für eine zielführende kardiologische Diagnostik stellt dabei die Planung der zu verwendenden Stressprotokolle in Abhängigkeit der jeweiligen klinischen Fragestellung dar. Die diagnostische und prognostische Aussagekraft der Stress-Echokardiografie ist hoch, wobei gerade in der Stress-Echokardiografie hohe Anforderungen an die praktischen Fähigkeiten und klinische Erfahrung des Untersuchers gestellt werden.
Treatment of varicose great saphenous veins with saphenofemoral junction insufficiency – what is the evidence?
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Authors: Holzheimer René Gordon , Obermayer Alfred , Noppeney Thomas 
Published: February 2020

AbstractThe results of studies on treatment of the great saphenous vein (GSV) with sapheno-femoral-junction (SFJ) insufficiency are unclear. Guidelines, however, recommend endovenous laser ablation (EVLA) and ultrasound-guided-foamsclerotherapy (UGFS) for symptomatic varicose large saphenous vein. There are numerous studies on GSV treatment but only a few randomized studies with a follow-up of two years and more. Meta-analyses in most instances included all studies and do not focus on studies with a follow-up of two years and longer.
Methods A literature research in Pubmed used the keyword “great saphenous vein treatment”, “large saphenous vein treatment”, “varicose therapy” in conjunction with “randomized controlled trial”, “meta-analysis” and “systematic review”. Of 128 studies only 24 randomized controlled studies investigated the effect of High Ligation and Continuous Stripping (HL + CS), Endovenous Laser Ablation (EVLA), Radiofrequency Ablation (RFA), Liquid Sclerotherapy (LS), and Ultrasound-Guided-Foam-Sclerotherapy (UGFS) and a follow-up of two and more years. Study evaluation included “reflux”, “recurrence”, “therapy technique”, numbers of patients/legs treated, length of follow-up, and primary/secondary study endpoints.
Results Most of these studies investigated surgical High Ligation and Continuous Stripping (HL + CS) with a follow-up of two years and more. This technique served a reference technique for other techniques in randomized controlled studies. However, there are major differences in techniques, mode of treatment, definitions, criteria for exclusion and inclusion, and study endpoints.The surgery study group included 1915 legs in 19 studies, the EVLA group 1047 legs in 12 studies and 240 legs in 3 studies with combined HL + EVLA treatment. RFA was used in 299 legs in 4 studies, UGFS in 661 legs in 5 studies, combined UGFS + HL in 39 legs and LS + HL in 92 legs in one study each.EVLA is associated with more reflux and recurrence when compared to HL + CS. RFA shows similar reflux and recurrence rates as surgery. In most studies UGFS and LS is followed by more reflux and recurrence when compared to surgery.
Conclusion Due to heterogeneity of studies comparing study results of HL + CS, EVLA, RFA, LS and UGFS is not reliable. UIP or ECOP may form a commission to establish uniform, reliable and accepted study designs for varicose vein treatment to improve comparability of further randomized studies.
Differences Between Men and Women with Fibromyalgia
Authors: Úbeda-D’Ocasar Edurne , Gallego-Sendarrubias Gracia M. , Guodemar-Pérez Jesus , Hervás-Pérez Juan Pablo 
Published: February 2020

Abstract
Objective While fibromyalgia (FM) affects both men and women, differences exist in several factors including prevalence, symptoms and attitudes. Understanding these differences will help define the best approach to the clinical management of this still poorly-understood disease. This systematic review sought to identify gender differences in FM.
Data sources The databases PubMed, Science Direct, Scielo, Scopus, Web of Science, and Pesquisa were searched using the terms “fibromyalgia”, “men” and “women” and the Boolean operators “AND” and “OR” for articles dealing with this topic published in any language in the past 20 years. The task force initially identified citations for 257 published articles.
Study selection Of 257 records extracted, 28 articles were finally selected for inclusion.
Data Extraction In the 28 studies, 2 studies were a clinical trial and the remaining studies were descriptive (10), observational studies (12), retrospective studies (2) and prospective studies (2). Articles were abstracted and quality of the studies determined using specific criteria.
Data Synthesis The methodological quality of the studies reported in these articles was good (PEDro score 6.00±1.3328). Gender differences were detected in FM prevalence, symptoms and coping.
Conclusions Overall, men with FM experienced more stress and worse sleep quality while women complained more of pain-related symptoms. Both sexes showed low physical activity levels. Both men and women responded well to manual treatment reporting substantial pain relief.