bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beneficial effects on fasting insulin and postprandial responses through 7-day intake of New Zealand blackcurrant powder
Authors: Willems Mark Elisabeth Theodorus , Silva Jose Dos Santos , Cook Matthew David , Blacker Sam David 
Published: December 2019

Background: Blood glucose and insulin are elevated after intake of carbohydrate, with levels returning to normal in about 2-3 hours after ingestion. We examined the effects of daily New Zealand blackcurrant intake over 7 days on fasting glucose and insulin levels and the responses of glucose and insulin during an oral glucose tolerance test (i.e. OGTT).Methods: Seventeen healthy participants (9 males, 8 females, age: 24±8 years, body mass: 75.4±16.4 kg, height 172±11 cm, body mass index: 25.3±3.3) consumed 6 g·day-1 New Zealand blackcurrant (NZBC) powder for 7 days. Every 6 g of the serving contained 138.6 mg anthocyanins, 49 mg vitamin C, and 5.2 g of carbohydrates with total phenolic content 271.6 mg. A cross-over design was used. Participants completed one OGTT before starting the supplementation (day 0) and another OGTT after 7 days of the supplementation (day 7). For the OGTT, participants were seated and consumed 75 g of glucose dissolved in 250 mL water. Finger prick capillary samples were taken before and every 30 minutes for a total of 120 minutes after consuming the glucose drink. Following duplicate glucose analysis, blood samples were centrifuged and then plasma was separated and frozen (-20°C) for triplicate insulin analysis using a human 96-well insulin enzyme-linked immunosorbent assay (IBL international, Hamburg, Germany).Results: NZBC had no effect on fasting glucose (control: 4.46±0.45; NZBC: 4.41±0.44 mmol·L1, P=0.657), although there was a trend for fasting insulin to be 14.3% lower (control: 66.5±28.2; NZBC: 57.0±29.5 pmol·L-1) (P=0.091). HOMA-IR was not different between the control and NZBC (1.81±0.73 vs 1.58±0.83) (P=0.126). With NZBC during the OGTT, plasma glucose at 60 min was 8.1% lower (control: 6.68±1.13; NZBC: 6.14±1.41 mmol·L-1; P=0.016), insulin at 30 min was 18.4% lower (control: 337.1±228.3; NZBC: 275.0±136.4 pmol·L-1; P= 0.021), and insulin at 60 min was 39.2% lower (control: 297.8±154.3; NZBC: 181.2±97.4 pmol·L-1; P= 0.002). With NZBC during the OGTTs, areas-under-the-curve for plasma glucose (control: 752.6±79.4, NZBC: 709.8±93.3 mmol·L-1·120 min) and insulin (control: 28443±12816, NZBC: 20406±7985, pmol·L-1·120 min) were 5.7% (P=0.051) and 31.1% lower (P<0.001) respectively. Conclusion: A trend for lower fasting insulin with normal glucose and lower areas under the curve for glucose and insulin suggests that repeated intake of New Zealand blackcurrant powder increases insulin sensitivity. This is the first observation of a high-anthocyanin containing berry powder to increase insulin sensitivity. Regular intake of New Zealand blackcurrant powder may be beneficial for the postprandial responses in people with type 2 diabetes or metabolic syndrome.Keywords: Anthocyanins, Glycaemia, Insulinaemia, Berries, Blood Glucose, Diabetes, Metabolic Syndrome
A new viscosupplement based on partially hydrophobic hyaluronic acid: A comparative study
Authors: Finelli Ivana , Chiessi Ester , Galesso Devis , Renier Davide , Paradossi Gaio 
Published: December 2019

A novel partially hydrophobized derivative of hyaluronic acid (HYADD®4), containing a low number of C16 side-chains per polysaccharide backbone, provides injectable hydrogels stabilized by side-chain hydrophobic interactions. The rheological properties of Hymovis®, a physical hydrogel based on the hyaluronic acid derivative HYADD®4, were evaluated using as reference a solution of the parent natural polysaccharide, hyaluronic acid. The rheological measurements were performed both in flow and oscillation regimes at the physiological frequency values of the knee, typically spanning the range from 0.5 Hz (walking frequency) to 3 Hz (running frequency). Moreover, the viscoelastic features of Hymovis® were compared with the market-available viscosupplementation products in view of its use in joint diseases. The different behavior of the investigated materials in crossover frequency measurements and in structure recovery experiments can be explained on the basis of the structural and dynamic properties of the polymeric systems.
Postoperative assessment of free skin flap viability by transcutaneous pO2 measurement using dynamic phosphorescence imaging
Authors: Geis S. , Schreml S. , Lamby P. , Obed A. , Jung E.M. , Nerlich M. , Babilas P. , Szeimies R.-M. , Prantl L. 
Published: December 2019

Background: Free flap transplantation is used more and more frequently in order to cover extensive wound defects. The basic prerequisite for successful flap salvage after flap failure is a short time interval from failure until revision. For this reason many different flap monitoring systems have been tested over the last years. But none of them has made the way into clinical routine. Objective: The aim of this clinical study was to study whether luminescence lifetime imaging (LLI) is an adequate method to assess flap viability during the postoperative period. In previous experiments LLI was proven to be a precise and non-invasive monitoring system for transcutaneous oxygen measurement. Methods: ptcO2 of 9 patients was detected during a postoperative period of 72 hours. In all cases the transplantation was performed by the same experienced surgeon. During the first 4 hours almost constant ptcO2 values were detected (53±0.7 mmHg). During the following time intervals ptcO2 values decreased and reached a more or less constant level after approximately 12 hours. The mean ptcO2 decreased from 53±0.7 mmHg to 39±1.0 mmHg. In one case an immediate decrease of ptcO2 below 10 mmHg was observed and a subsequently intervention was necessary to improve flap perfusion. Conclusion: In this clinical trial, perfusion dynamics after free flap transplantation as well as the detection of vascular complications were demonstrated using LLI. Based on these data, LLI seems to be a sensitive and adequate monitoring system for the evaluation of free flap viability.
New real-time image fusion technique for characterization of tumor vascularisation and tumor perfusion of liver tumors with contrast-enhanced ultrasound, spiral CT or MRI: First results
Authors: Jung E.M. , Schreyer A.G. , Schacherer D. , Menzel C. , Farkas S. , Loss M. , Feuerbach S. , Zorger N. , Fellner C. 
Published: December 2019

Aim: Evaluation and characterization of the vascularisation and perfusion of liver tumors by means of image fusion of dynamic contrast-enhanced ultrasound (CEUS), multidetector-CT (MD-CT) or magnetic resonance imaging (MRI) with the ultrasound navigation technique. Material: For interventional planning a real-time image fusion involving CEUS (LOGIQ E9, GE) was performed in 20 patients (12 men, 8 women, age 43–69 years, median 54) with histologically confirmed malignant liver tumors (9 × hepatocellular carcinoma (HCC), 5 × metastases, 2 × hemangiomas, 1 × cholangiocellular carcinoma (CCC), 1 × lymphoma, 1 × neuroendocrine tumor, 1 × focal nodular hypoplasia (FNH)). In 17 patients the real-time CEUS was fused with contrast-enhanced MD-CT and in three patients with contrast-enhanced MRI (Gd-DTPA and liver-specific contrast medium Resovist®). All of the ultrasound examinations were performed by an experienced examiner with a multi-frequency probe (2–5 MHz, LOGIQ E9, GE); dynamic image sequences up to 3 minutes in true agent detection mode of contrast harmonic imaging (CHI) were documented. An evaluation of the tumor was performed by the characterization of the dynamics of the contrast medium and microperfusion with CEUS, fused with MD-CT or MRI. Results: In 18/20 cases there was an accurate agreement with respect to the segmental localization of the tumor lesion. In 2/20 cases the localization was comparable with the image fusion of CEUS and reference imaging (a total of at least 65 lesions: 3 × 1 lesion, 5 × 2 lesions, 8 × 3 lesions, 2 × 5 lesions, 1 × 8 lesions, 1 × at least 10 lesions (multifocal)). With image fusion a certain characterization was attained in 17/20 cases. In 3/20 cases (lymphoma after liver transplantation, multifocal CCC, metastases of a neuroendocrine tumor) the diagnosis was at first doubtful and had to be confirmed histologically. In patients with HCC an evaluation of the tumor perfusion was feasible in all 9 cases (8/9 after local trans-arterial chemoembolization (TACE), 1/9 after radio frequency ablation (RFA)). A tendency toward the identification of more lesions with image fusion of CEUS and CT than with contrast-enhanced CT alone could be recognized (p=0.059). Conclusion: Applying a new real-time fusion technique of MD-CT or MRI with CEUS new possibilities for the evaluation, intervention and monitoring of the therapy of liver lesions were made possible, since the method also comprised the dynamic microperfusion.
Permeability of technical and biological tissues
Authors: Franke R.P. , Fuhrmann R. , Hiebl B. , Mrowietz C. , Jung F. 
Published: December 2019

The permeability of a material is described by the amount of substances (gases, liquids, particles) passing through pores and/or interstices of the material in a certain time. In medicine and biotechnology the permeability is given usually as the amount of water (ml × cm−2 × min−1) permeating per area and time unit through the material. Vascular prostheses are described e.g. as high porous prostheses (e.g. Dacron™: 1500–4000 (ml × cm−2 × min−1)) or as low porous prostheses (e.g. ePTFE: 200–1000 (ml × cm−2 × min−1)). The permeability of blood capillaries is characterized by the exchange of nutrients, metabolites and breathing gases. Capillary permeability and the transport of the permeates through tissues are the key processes for the supply of organs and tissues where especially the protein transport through tissues is described by diffusive and/or convective terms. The vascular permeability is governed by the permeability of the intimal endothelial cells. The major influence is exerted by the interendothelial binding which can change drastically in a very short time. This is demonstrated by the fast development of interstitial lung oedema in case of septical shock. The permeability is an integral indicator of tissue and organ function. It is possible to assess the permeability of native and engineered tissues precisely with a recently developed system. First results will be shown.
Influence of radiographic contrast media on the secretion of vasoactive substances by primary human umbilical venous endothelial cells (HUVEC): Prospective, controlled, in vitro comparative study
Authors: Franke R.P. , Fuhrmann R. , Hiebl B. , Jung F. 
Published: December 2019

Besides the desirable effect of roentgen ray absorption radiographic contrast media (RCM) can also have varying adverse effects. Under discussion, as a possible cause, are microcirculatory disorders resulting from morphological alterations in erythrocytes and endothelial cells. Therefore, the contrast media-induced release of vasoactive substances (prostacyclin, endothelin-1, and nitric oxide (NO)) from human endothelial cells (HUVEC) induced by two commercially available RCMs (Iodixanol 320, Iomeprol 350) was tested in a controlled in-vitro study. The results show that RCMs lead to endothelial cell trauma in vitro, which is apparent in the release of prostacyclin and endothelin-1, while NO release was not affected. The endothelin-1 release after incubation with Iodixanol was similar to the release in the control cultures. In comparison, lower endothelin-1 levels were measured in the cultures incubated with Iomeprol at all 3 time points indicating a more significant cell trauma. Prostacyclin release – also an indicator of traumatization of endothelial cells – increased after addition of both contrast agents. The highest release was found after incubation with Iomeprol 350.
Semiquantitative characterization of hepatocellular carcinoma (HCC) – perfusion with contrast-enhanced ultrasound and perfusion analysis
Authors: Schacherer D. , Girlich C. , Wiest R. , Büttner R. , Schölmerich J. , Feuerbach S. , Zorger N. , Hamer O.W. , Jung E.M. 
Published: December 2019

Background: At the moment, there is only poor specificity of HCC-detection in tumors smaller than 2 cm in a cirrhotic liver. Thus, efforts have to be made to optimize the distinction between regenerative nodules and HCC. Aims: The aim of our study was to describe the particular perfusion pattern of hepatocellular carcinoma using a specific quantification software. Methods: We evaluated 25 patients with proven hepatocellular carcinoma, who underwent dynamic contrast-enhanced ultrasound (CEUS) using a second generation contrast agent (SonoVue®, Bracco, Germany). Retrospectively, we applied the quantification software Qontrast® (Bracco, Milan, Italy) to obtain contrast-enhanced sonographic perfusion maps for each lesion. Results: We found a close positive correlation of the perfusion parameters peak, time-to-peak and regional blood volume between the entire tumors, the center (center/total) and the periphery of the tumors (periphery/total), respectively. Moreover, we found significant higher peak values, a significant higher regional blood volume and a trend to lower time-to-peak in the center of the tumors compared to the tumor periphery. Conclusion: These results suggest a better established vascular bed in the center of the tumors. This could be a sonographic marker of HCC in contrast to regenerative nodules.
Effect of vitamin E on reperfusion injuries during reconstructive vascular operations on lower limbs
Authors: Arató E. , Kürthy M. , Sínay L. , Kasza G. , Menyhei G. , Hardi P. , Masoud S. , Ripp K. , Szilágyi K. , Takács I. , Miklós Z. , Bátor A. , Lantos J. , Kollár L. , Rőth E. , Jancsó G. 
Published: December 2019

Introduction: The challenge against reperfusion injury and tissue oxidative stress, especially in vascular surgical interventions has an essential importance to reach the optimal clinical result. Numerous experimental attempts have proved the positive antioxidant effect of vitamin E in both chronic and acute phase models. In our study we monitored the effect of continuous preoperative treatment with vitamin E, on oxidative stress and tissue inflammation reactions developed after reconstructive operations. Patients and methods: 32 patients have been involved in a randomized, prospective study, all suffering from AFS occlusion proved by angiography, and all undergone supragenual reconstruction. Duration of ischemia and amount of tissues under vascular clamping were almost the same in all patients. In the group treated with E-vitamin, we administered 1×200 mg of vitamin E p/o from the preoperative day till the 7th post operative day. Patients of the second group did not receive vitamin E. Materials and methods: Peripheral blood samples were collected immediately before operation and at the end of the second reperfusion hour (early reperfusion period). Late reperfusion period has been monitored by analyzing blood samples taken at 24th hour and 7th day next to the operative ischemia. Among oxidative stress parameters, direct measurement of reactive oxygen intermediator (ROI) and determination of antioxidant state (GSH, Total-SH group, SOD) have been performed. Malondialdehyde was chosen as marker for lipidperoxidation. Inflammation reactions were monitored up on expression of adhesion molecules (CD11a and CD18). We also controlled the oscillation of myeloperoxidase (MPO) activity. Results: Our study has proved that preoperative (from the preoperative day till the 7th post operative day) administration of 200 mg vitamin E could reduce the level of oxidative stress developed after ischemic-reperfusion insult (lipidproxidation, antioxidant enzymes). According to our results, the prooxidant-antioxidant imbalance also diminished in the group with E-vitamin treatment. We proved that elective administration of vitamin E could decrease the WBC activity (MPO activity, free radicals production, expression of adhesion molecules) and its consequential local inflammation process, during early reperfusion.
Nasopharyngeal Tuberculosis in a Philippine Tertiary General Hospital
Authors: Gomez Mark Anthony , Villarta Romeo , Caro Ruzanne , Manasan Criston Van , Carnate Jose 
Published: December 2019

Objective:  This study aimed to determine the prevalence of nasopharyngeal tuberculosis among patients who were initially assessed to have a nasopharyngeal mass and subsequently underwent biopsy in a Philippine Tertiary General Hospital from 2013 to 2015.

Methods:
Design: Case Series
Setting: Tertiary National University Hospital
Participants: All patients with nasopharyngeal mass identified from January 2013 to December 2015 from a hospital wide census who underwent biopsy were investigated using chart and histopathology review. The prevalence of tuberculosis, malignancies and other findings were determined.

Results:  Among 285 nasopharyngeal biopsies done between 2013 and 2015, 33 (11.6%) were histologically compatible with nasopharyngeal tuberculosis, 177 (62.1%) were different types of nasopharyngeal carcinoma, 59 (20.7%) were chronic inflammation, 4 (1.4%) were lymphoma, 5 (1.8%) were normal, and 7 (2.5 %) had diagnoses other than those above.

Conclusion: This study suggests a relatively high prevalence rate (11.6%) of nasopharyngeal tuberculosis in patients who have a nasopharyngeal mass. This indicates that nasopharyngeal tuberculosis should always be a differential when confronted with a mass in the nasopharynx especially in tuberculosis endemic areas.

Keywords: nasopharyngeal tuberculosis; prevalence; censuses; tertiary care centers; Philippines; carcinoma; nasopharynx; biopsy; tuberculosis; lymphoma
THE CONCEPT OF CHINESE-INDONESIAN-NESS AS SEEN FROM ERNEST PRAKASA’S ROLES IN NGENEST, CEK TOKO SEBELAH, SUSAH SINYAL AND STIP & PENSIL
Authors: Sutandio Anton , Angjaya Sonny 
Published: December 2019

This article discusses four films entitled Ngenest (2015), Cek Toko Sebelah (2016), Susah Sinyal (2017), and Stip & Pensil (2017) in which Ernest Prakasa played a role, in the context of how the four films construct Chinese-Indonesian-ness. In the context of cinema, the appearance of Chinese-Indonesians on the screen during the New Order regime was scarce, and if there is any, the depiction was highly stereotyped. Only after Reform era in the late 1990s that Chinese-Indonesians and their culture began to re-appear on screen. Ernest Prakasa is one of few Chinese-Indonesians who publicly celebrates his Chinese-ness through entertainment platform. Ethnic identity theory applied on the discussion of the film cinematography and mise-en-scene to show what the films say about the concept of Chinese-Indonesian-ness. The findings show that Prakasa not only celebrates being a Chinese-Indonesian, but he also performs a self-mockery as Chinese-Indonesians by explicitly emphasizing the Chinese-Indonesians stereotypes. He also tries to re-establish inter-ethnic relationship and introduce contemporary Chinese-Indonesian-ness concept through his films.
PENERAPAN PERSEPSI ORANGTUA DALAM MEMENUHI HAK PARTISIPASI ANAK USIA 9-12 TAHUN DI DESA BENA AMANUBAN SELATAN NUSA TENGGARA TIMUR
Authors: Nitti Lodiana , Thoomaszen Friandry Windisany 
Published: December 2019

ABSTRACT
Parental perception will affect the fulfillment of childrenâ€™s participation rights. Fullfilment of childrenâ€™s participation rights will be fulfilled optimally if parents pay anttention to opinions while providing opportunities for children to make and make decisions about the childâ€™s goals and self-interest. The subjects studied consisted of 5 subjects consisting of father and mother who had children aged 9- 12 years. This study uses qualitative research methods, with data retrieval tools in teh form of interviews, observation and documentation. From the research found data were the subjects do not fulfill the right of participation of children up to the maximum ladder where childrenâ€™s participation rights range from the first ladder to the third ladder. The first ladder to the third ladder is actually a non- participating ladder. This means that children is manipulated, dominated by parents, there is direct communation and the severity of the parent. The children felt disappointed, sad, and angry with the parents but they still tried to hear and obey the parentâ€™s decision. Children from third and fourth subjects experienced excessive fear to speak to their parent (father). Suggestions for parents to be more caring and fulfill the rights of childrenâ€™s participation so as not to affect the growth and development of children.
Keywords: participation rights, children, parents
The Prelude of Skill Development for Women Enterpreneurs
Authors: Sawale Sangharsha Baliram 
Published: December 2019

The skill development means is the trainings which isprovide by the institutions or government to improve the skill, quality and efficiency for the entrepreneurs at the workplace. The importance of the trainings to ensure avaibility of skilled manpower at all management levels, enhancing ability, potential among entrepreneurs, increase, efficiency, maintain and enhance, product quality, minimize wastages in production process, reduce fatigue and increase speed of work etc. Todays Government support to the women entrepreneurship development through MSME and DIC and another side make in India, start Up India, stand up India and other various schemes also. And to develop the entrepreneurship Government provides the various types of trainings and skill developments programmers to the people who wanted to start their business, entrepreneurs to start their business and develop their business successfully.
This paper emphasized on the skill development programmes for women entrepreneurs by the government of India. For the purpose of women entrepreneurs development. The research paper is based on secondary data which is available on the websites, journals, book and articles.
Redefining Masculinity in Haruki Murakami's Men Without Women
Authors: Mukherjee Susmita , K Swamy Sumathy 
Published: December 2019

For centuries, the concept of the ideal man being macho has dominated over all forms of culture. In literature too male protagonists have been portrayed as strong men who are in control of their emotions. Any form of emotional expression from a man is deemed to be weak and labeled as effeminate. However, contemporary writers like Haruki Murakami are changing the ways in which men are portrayed in literature. Murakami makes his male characters vulnerable to pain and sadness thereby challenging the hegemonic notions of masculinity. The paper focuses on Murakami’s collection of short stories titled Men without Women, and studies the male characters in some of these short stories. It attempts to understand the changing definitions of masculinity and probes into what constitutes masculinity.