bluuebunny/crossref_metadata_2025_split huggingface dataset:
Guillain‐Barré syndrome in a man presenting with upper extremity monoplegia
Authors: Gowan Jacqueline Marie , Golla Abhinav , Liu Antonio 
Published: March 2020

AbstractOutside academia, community and rural medical centers often rely on clinical signs and symptoms for early intervention, as means of gathering objective data may be unavailable, or the reliance of biological testing may take too long to return. Continued reporting of atypical presentations is therefore necessary for broadening clinical recognition of such cases.
Intracardiac ultrasound‐guided left bundle branch pacing in a bradycardia patient
Authors: Zhang Jiefang , Sun Yaxun , Zhang Zuwen , Jiang Chenyang , Fu Guosheng 
Published: March 2020

AbstractLeft bundle branch pacing was associated with narrower QRS in patients with pacemaker indications. LBBP guided by ICE improves the accuracy of LBBP, facilitates the lead localization, minimizes complications, and above all reduces radiation exposure time.
Recent Enzymatic Electrochemistry for Reductive Reactions
Authors: Cadoux Cécile , Milton Ross D. 
Published: March 2020

AbstractEnzymatic electrochemistry is the coupling of oxidoreductase enzymes to electrodes, where electrons are transferred between the electrode and an enzyme's cofactor(s). In addition to enzymatic electrochemistry enabling mechanistic study [such as the determination of cofactor reduction potential(s)], enzymatic electrocatalysis also enables substrate reduction or oxidation by exploiting the catalytic properties of enzymes. This Minireview illustrates some recent examples, in which electrodes are coupled with enzymes that catalyze the reduction of substrates such as dinitrogen (N2), carbon dioxide (CO2) and protons (H+), performed by metalloenzymes such as nitrogenases, formate dehydrogenases and hydrogenases. We review some strategies to achieve electron transfer (such as mediated and direct electron transfer), as well as some key results of recent studies.
Enhanced Long Persistent Luminescence by Multifold Interpenetration in Metal–Organic Frameworks
Authors: Wang Zheng , Zhu Cheng‐Yi , Fu Peng‐Yan , Mo Jun‐Ting , Ruan Jia , Pan Mei , Su Cheng‐Yong 
Published: March 2020

AbstractMetal–organic frameworks (MOFs) with long persistent luminescence (LPL) have attracted widespread attention due to potential applications in displays, anticounterfeiting, and so on. However, MOFs often have large pore size, which restricts the formation of efficient inter‐ and intramolecular interactions to realize LPL. Herein, a new approach to achieving LPL in MOFs by multifold interpenetration of discrete frameworks is reported. By comparison between threefold‐ and twofold‐interpenetrating MOFs, it was found that the former, which have higher multiplicity and denser frameworks, can be endowed with enhanced inter‐ and intramolecular interactions, and thus enhanced LPL is obtained. Meanwhile, metal‐cluster and heavy‐halogen effects could also cause variations in LPL duration and color.
Monohydride‐Dichloro Rhodium(III) Complexes with Chiral Diphosphine Ligands as Catalysts for Asymmetric Hydrogenation of Olefinic Substrates
Authors: Higashida Kosuke , Brüning Fabian , Tsujimoto Nagataka , Higashihara Kenya , Nagae Haruki , Togni Antonio , Mashima Kazushi 
Published: March 2020

AbstractWe report full details of the synthesis and characterization of monohydride‐dichloro rhodium(III) complexes bearing chiral diphosphine ligands, such as (S)‐BINAP, (S)‐DM‐SEGPHOS, and (S)‐DTBM‐SEGPHOS, producing cationic triply chloride bridged dinuclear rhodium(III) complexes (1 a: (S)‐BINAP; 1 b: (S)‐DM‐SEGPHOS) and a neutral mononuclear monohydride‐dichloro rhodium(III) complex (1 c: (S)‐DTBM‐SEGPHOS) in high yield and high purity. Their solid state structure and solution behavior were determined by crystallographic studies as well as full spectral data, including DOSY NMR spectroscopy. Among these three complexes, 1 c has a rigid pocket surrounded by two chloride atoms bound to the rhodium atom together with one tBu group of (S)‐DTBM‐SEGPHOS for fitting to simple olefins without any coordinating functional groups. Complex 1 c exhibited superior catalytic activity and enantioselectivity for asymmetric hydrogenation of exo‐olefins and olefinic substrates. The catalytic activity of 1 c was compared with that of well‐demonstrated dihydride species derived in situ from rhodium(I) precursors such as [Rh(cod)Cl]2 and [Rh(cod)2]+[BF4]− upon mixing with (S)‐DTBM‐SEGPHOS under dihydrogen.
Green‐Light Activation of Push–Pull Ruthenium(II) Complexes
Authors: Moll Johannnes , Wang Cui , Päpcke Ayla , Förster Christoph , Resch‐Genger Ute , Lochbrunner Stefan , Heinze Katja 
Published: March 2020

AbstractSynthesis, characterization, electrochemistry, and photophysics of homo‐ and heteroleptic ruthenium(II) complexes [Ru(cpmp)2]2+ (22+) and [Ru(cpmp)(ddpd)]2+ (32+) bearing the tridentate ligands 6,2’’‐carboxypyridyl‐2,2’‐methylamine‐pyridyl‐pyridine (cpmp) and N,N’‐dimethyl‐N,N’‐dipyridin‐2‐ylpyridine‐2,6‐diamine (ddpd) are reported. The complexes possess one (32+) or two (22+) electron‐deficient dipyridyl ketone fragments as electron‐accepting sites enabling intraligand charge transfer (ILCT), ligand‐to‐ligand charge transfer (LL'CT) and low‐energy metal‐to‐ligand charge transfer (MLCT) absorptions. The latter peak around 544 nm (green light). Complex 22+ shows 3MLCT phosphorescence in the red to near‐infrared spectral region at room temperature in deaerated acetonitrile solution with an emission quantum yield of 1.3 % and a 3MLCT lifetime of 477 ns, whereas 32+ is much less luminescent. This different behavior is ascribed to the energy gap law and the shape of the parasitic excited 3MC state potential energy surface. This study highlights the importance of the excited‐state energies and geometries for the actual excited‐state dynamics. Aromatic and aliphatic amines reductively quench the excited state of 22+ paving the way to photocatalytic applications using low‐energy green light as exemplified with the green‐light‐sensitized thiol–ene click reaction.
Aqueous‐Based Low‐Temperature Synthesis and Thin‐Film Properties of Oxysulfide BiCuOS Nanoparticles
Authors: Gamon J. , Haller S. , Giaume D. , Robert C. , Thomas C. M. , D'Alençon L. , Buissette V. , Le Mercier T. , Barboux P. 
Published: March 2020

AbstractBiCuOS is a nontoxic p‐type semiconductor that is a promising candidate for photoelectric applications. The formation of thin films with a good electronic transport at the grain boundaries, while avoiding thermal treatment detrimental to its chemical stability is a challenge. We have developed a chemical method for the direct synthesis of stable colloidal suspensions of BiCuOS nanoparticles from soluble precursors. These colloidal solutions were stabilized with a catechol functionalized poly‐3‐hexylthiophene that allows easy spin‐coating deposition and favors electronic transport along the grain boundaries. Stacking of ZnO–BiCuOS layers were achieved, allowing preparation of n–p junctions. These act as rectifying diodes and are strongly photosensitive, with Iph/Idark=85 corresponding to an enhancement of the photocurrent of more than two orders of magnitude compared to that of BiCuOS alone. This energy‐efficient and low‐cost method is a further step in the development of new sulfide semiconductor devices.
Switching on the Fluorescence Emission of Polypyridine Ligands by Simultaneous Zinc(II) Binding and Protonation
Authors: Conti Luca , Giorgi Claudia , Valtancoli Barbara , Paoli Paola , Rossi Patrizia , Marchionni Andrea , Faggi Enrico , Bencini Andrea 
Published: March 2020

AbstractThe synthesis and characterization of the two new open‐chain ligands 1,15‐bis‐[6‐(2,2’‐bipyridyl)]‐2,5,8,11,14‐pentaaza‐octadecane (L1) and 1,15‐bis‐[2‐(1,10‐phenanthroline)‐9‐methyl]‐2,5,8,11,14‐pentaazaoctadecane (L2), both featuring a tetraethylenpentaamine chain linking via methylene bridges the 6 and 2 positions of two identical 2,2’‐bipyridyl (bpy) and 9‐methyl‐1,10‐phenanthroline (9‐methyl‐phen) moieties respectively, are reported. Their protonation and binding ability for Cu2+, Zn2+, Cd2+ and Pb2+ have been studied by coupling potentiometric titrations with UV‐vis absorption and fluorescence emission measurements in water. L1 and L2 afford stable mono‐ and dinuclear complexes, in which the metal ion is bound by a single bpy or 9‐methyl‐phen unit and the amine groups on the aliphatic chain. However, L1 displays a greater binding ability for Cu2+ and Zn2+ with respect to L2, the stability constants of the [ML1]2+ complexes being 21.8 (Cu2+) and 19.4 (Zn2+) log units vs 20.34 and 16.8 log. units for the corresponding L2 species. Among all the metal ions tested, only the Zn2+ complex with L2 features an enhanced fluorescence emission at neutral pH, thanks to the simultaneous binding of one Zn2+ ion and H+ ion(s), that inhibits any possible photoinduced electron transfer (PET) process from the amine donors to the excited phen moiety. Binding of a second metal switches off the emission again.
A diallel analysis of a maize donor population response to in vivo maternal haploid induction: II. Haploid male fertility
Authors: De La Fuente Gerald N. , Frei Ursula K. , Trampe Benjamin , Ren Jiaojiao , Bohn Martin , Yana Nicole , Verzegnazzi Anderson , Murray Seth C. , Lübberstedt Thomas 
Published: March 2020

AbstractDoubled haploid (DH) lines are used in maize (Zea mays L.) breeding to accelerate the breeding cycle and create homogenous inbred lines in as little as two seasons. These pure inbred lines allow breeders to quickly evaluate new cross combinations. There are two important steps in creating DH lines: (a) generation and selection of haploid progeny, and (b) genome doubling to create fertile, diploid inbreds. Colchicine is widely used to artificially double genomes in haploid plants, which is hazardous, expensive, and time consuming. In this study, three public inbred lines—A427, A637, and NK778—were found to have substantial haploid male fertility (HMF). A six‐parent full diallel between these three HMF lines and three non‐HMF lines was created and HMF was scored. Diallel analysis revealed significant general combining ability (GCA) estimates of up to 17% for HMF, as well as significant specific combining ability (SCA) effects of up to 25%. No significant reciprocal effects were found. Haploid male fertility is promising to be incorporated into elite maize breeding programs to potentially overcome the need of using colchicine treatments for genome doubling. Colchicine aided doubling success rates varying from almost 0 to 30%. Haploid male fertility has an advantage over artificial genome doubling, in terms of both increased success rates and decreased costs for DH line production.
Incidence of stroke in the diabetic compared with the non‐diabetic population: A systematic review protocol
Authors: Kvitkina Tatjana , Narres Maria , Claessen Heiner , Metzendorf Maria‐Inti , Richter Bernd , Icks Andrea 
Published: March 2020

SummaryPeople with diabetes have a largely increased risk of stroke compared with people without diabetes. Exact data on incidence of stroke in people with and without diabetes are important for improvements in preventive diabetes care, avoidance of fatal outcomes and as a solid basis for health policy and the economy. However, published data are conflicting, underlining the necessity for this systematic review of population‐based studies on incidence, relative risks (RRs) and changes in stroke rates over time. The purpose of our review is to evaluate the incidence of stroke in the diabetic population and its differences with regard to sex, ethnicity, age and regions; to compare the incidence rate (IR) in the diabetic and non‐diabetic populations and to investigate time trends. We will perform a systematic literature search in MEDLINE, Embase and LILACS designed by an experienced information scientist. Two review authors will independently screen the abstracts and full texts of all references on the basis of inclusion criteria regarding types of study, types of population and the main outcome. Data extraction and assessment of risk of bias will be undertaken by two review authors working independently. We will assess IR or cumulative incidence (CumI) and RR of stroke comparing the diabetic and non‐diabetic populations. The attributable risk (AR = proportion of stroke among persons with diabetes that is attributable to diabetes) and the population attributable risk (PAR = proportion of stroke in the whole population that is attributable to diabetes) will be considered where available. In conclusion, this review will help to summarize the available evidence for incidence of stroke in the diabetic and nondiabetic population. The publication of this protocol will contribute to making the search strategy, methods, and assessment of reviews transparent and accessible for all involved professional groups.
A global assessment of the vulnerability of shellfish aquaculture to climate change and ocean acidification
Authors: Stewart‐Sinclair Phoebe J. , Last Kim S. , Payne Ben L. , Wilding Thomas A. 
Published: March 2020

AbstractHuman‐induced climate change and ocean acidification (CC‐OA) is changing the physical and biological processes occurring within the marine environment, with poorly understood implications for marine life. Within the aquaculture sector, molluskan culture is a relatively benign method of producing a high‐quality, healthy, and sustainable protein source for the expanding human population. We modeled the vulnerability of global bivalve mariculture to impacts of CC‐OA over the period 2020–2100, under RCP8.5. Vulnerability, assessed at the national level, was dependent on CC‐OA‐related exposure, taxon‐specific sensitivity and adaptive capacity in the sector. Exposure risk increased over time from 2020 to 2100, with ten nations predicted to experience very high exposure to CC‐OA in at least one decade during the period 2020–2100. Predicted high sensitivity in developing countries resulted, primarily, from the cultivation of species that have a narrow habitat tolerance, while in some European nations (France, Ireland, Italy, Portugal, and Spain) high sensitivity was attributable to the relatively high economic value of the shellfish production sector. Predicted adaptive capacity was low in developing countries primarily due to governance issues, while in some developed countries (Denmark, Germany, Iceland, Netherlands, Sweden, and the United Kingdom) it was linked to limited species diversity in the sector. Developing and least developed nations (n = 15) were predicted to have the highest overall vulnerability. Across all nations, 2060 was identified as a tipping point where predicted CC‐OA will be associated with the greatest challenge to shellfish production. However, rapid declines in mollusk production are predicted to occur in the next decade for some nations, notably North Korea. Shellfish culture offers human society a low‐impact source of sustainable protein. This research highlights, on a global scale, the likely extent and nature of the CC‐OA‐related threat to shellfish culture and this sector enabling early‐stage adaption and mitigation.
Photocatalytic reduction of CO2 to methanol over ZnFe2O4/TiO2 (p–n) heterojunctions under visible light irradiation
Authors: Iqbal Farukh , Mumtaz Asad , Shahabuddin Syed , Abd Mutalib Mohamed Ibrahim , Shaharun Maizatul Shima , Nguyen Trinh Duy , Khan Maksudur Rahman , Abdullah Bawadi 
Published: March 2020

AbstractBACKGROUNDThe development of visible light photocatalysts for CO2 reduction into methanol is a challenge, as most of the reported photocatalysts can only work in a UV light environment. Slow kinetics and poor selectivity of CO2 towards methanol are currently two significant drawbacks limiting the practical application of CO2 reduction into methanol.RESULTSA ZnFe2O4/TiO2 heterojunction with a ratio of unity was found to lead to the highest methanol yield of 693.31 μmol (g cat)−1 under a light intensity of 100 mW cm−2. This photocatalyst also possessed the highest BET surface area of 6.5211 m2 g−1 and better morphological structure, as compared with other ratios (1:2, 2:1 w/w). Interestingly, a loading of 1 g L−1 of ZnFe2O4/TiO2 (1:1) heterojunction photocatalyst in the pre‐annealing treatment of ZnFe2O4 at 900 °C and post‐annealing treatment of ZnFe2O4/TiO2 (1:1) composite at 500 °C revealed that there was an enhancement in the interfacial interaction, and subsequently an efficient photoreduction of CO2 into methanol.CONCLUSIONSThis study demonstrates facile fabrication of p–n heterostructured phototcatalysts for reduction of CO2 with marked improvement in methanol yield under visible light irradiation. It provides a viable route for exploring the effects of composition, hydrothermal treatment, and pre‐/post‐annealing treatment of hybrid semiconductor composites used to scale up photocatalytic CO2 conversion in solar fuel‐based devices.
Patient perspectives on the diagnostic journey to a monogenic diabetes diagnosis: Barriers and facilitators
Authors: Guan Yue , Maloney Kristin A. , Pollin Toni I. 
Published: March 2020

AbstractMost monogenic diabetes is misdiagnosed as either type 1 or type 2 diabetes (T1D/T2D). Few studies have examined the diagnostic challenges from the patients’ perspective. This qualitative study aimed to investigate patients’ journeys to obtaining a diagnosis of maturity‐onset diabetes of the young (MODY) by elucidating the range of factors that can act as barriers and facilitators throughout this process. We recruited participants from the Personalized Diabetes Medicine Program (PDMP) at University of Maryland and used respondent‐driven sampling to recruit additional patients. We conducted qualitative phone interviews between October 2016 and June 2017 with nine patients with diagnoses of monogenic diabetes (one HNF4A‐MODY, seven GCK‐MODY, and one HNF1A‐MODY) and one parent of a patient with INS‐MODY. Interview data were audio recorded, transcribed, and analyzed both inductively and deductively using thematic content analysis. All patients were female, with a mean age of 35 (range: 7–67 years). The amount of time these patients were misdiagnosed ranged from a few months to 41 years. We identified barriers and facilitators in three broad themes: (a) patient‐related (nature of MODY symptoms, perceived test utility, individual personality); (b) provider‐related (provider awareness and knowledge, provider communication); and (c) healthcare system‐related (cost of testing, access to knowledgeable providers, patient education, and support resources). The diverse range of barriers and facilitators reiterates the complexity of the MODY diagnostic process. Limited awareness and knowledge of MODY from healthcare professionals and patients themselves account for most diagnostic delays described in this study. Efforts to promote awareness of MODY and expand access to screening and testing may result in quicker diagnosis and ensure the downstream benefits of proper treatment.
Synthesis, antibacterial, and antioxidant activities of naphthyl‐linked disubstituted 1,2,3‐triazoles
Authors: Kaushik Chander Prakash , Luxmi Raj 
Published: March 2020

AbstractHere, click synthesis of 15 naphthyl‐linked disubstituted 1,2,3‐triazoles has been carried out by the reaction between 1‐(prop‐2‐yn‐1‐yloxy)naphthalene and aromatic azides. The structure elucidation of the synthesized compounds was carried out by FTIR, 1H NMR, 13C NMR, and HRMS techniques. Further, the compound 7f was confirmed by X‐ray crystallography (CCDC 1876891). The synthesized compounds were explored for antibacterial activity against Bacillus cereus, Escherichia coli, and Staphylococcus aureus. Biological evaluation of synthesized 1,2,3‐triazoles revealed moderate to good antibacterial activity against the tested strains. The antioxidative behavior of synthesized compounds manifested the remarkable free radical scavenging activity using DPPH assay.
Adenovirus infection among pediatric patients with cancer and in pediatric recipients of hematopoietic stem cell: A multicenter nationwide study
Authors: Zając‐Spychała O. , Pieczonka A. , Wachowiak J. , Frączkiewicz J. , Salamonowicz M. , Kałwak K. , Gorczyńska E. , Kazanowska B. , Wróbel G. , Chybicka A. , Czyżewski K. , Dziedzic M. , Wysocki M. , Zalas‐Więcek P. , Szmydki‐Baran A. , Hutnik Ł. , Matysiak M. , Irga‐Jaworska N. , Bień E. , Drożyńska E. , Stolpa W. , Sobol‐Milejska G. , Pierlejewski F. , Młynarski W. , Gryniewicz–Kwiatkowska O. , Gietka A. , Dembowska‐Bagińska B. , Semczuk K. , Dzierżanowska‐Fangrat K. , Gamrot‐Pyka Z. , Woszczyk M. , Urbanek‐Dądela A. , Karolczyk G. , Płonowski M. , Krawczuk‐Rybak M. , Zaucha‐Prażmo A. , Kowalczyk J. , Goździk J. , Styczyński J. 
Published: March 2020

AbstractThe aim was to evaluate the incidence, clinical course, and outcome of adenoviral infection (AdVI) in pediatric patients diagnosed and treated due to cancer and in pediatric recipients of hematopoietic stem cell. Over a 72‐month period, all‐in 5599 children with cancer: 2441 patients with hematological malignancy (HM) and 3158 with solid tumors (ST), and 971 patients after transplantation: 741 after allogeneic (allo‐HSCT) and 230 after autologous (auto‐HSCT) were enrolled into the study. Among cancer patients, 67 episodes of AdVI appeared in 63 (1.1%) children, including 45 (1.8%) with HM and 18 (0.6%; P < .001) with ST. Within transplanted patients, AdVIs were responsible for 88 episodes in 81 (8.3%) children (P < .001), including 78 (10.5%) patients after allo‐HSCT and 3 (1.3%) after auto‐HSCT. Time to develop AdVI was short, especially after allo‐HSCT. The most common clinical manifestation in cancer patients was enteritis diagnosed in 63 (94.0%) cases, while among HSCT recipient asymptomatic adenoviremia was found in 36 (40.9%) cases and the most common clinical manifestation was urinary tract infection. Cancer patients with disseminated disease, as well as HSCT recipients with either asymptomatic viremia or disseminated disease, received antiviral treatment. The most commonly used first‐line therapy was cidofovir. None of the cancer patients died due to AdVI, while within HSCT recipients three patients developed disseminated adenoviral disease and died despite antiviral treatment. In cancer patients, AdVIs are rare and associated with very good prognosis even without specific treatment. However, in allo‐HSCT recipients, disseminated disease with fatal outcome is more likely to occur.
COVID‐19 patients' clinical characteristics, discharge rate, and fatality rate of meta‐analysis
Authors: Li Long‐quan , Huang Tian , Wang Yong‐qing , Wang Zheng‐ping , Liang Yuan , Huang Tao‐bi , Zhang Hui‐yun , Sun Weiming , Wang Yuping 
Published: March 2020

AbstractThe aim of this study was to analyze the clinical data, discharge rate, and fatality rate of COVID‐19 patients for clinical help. The clinical data of COVID‐19 patients from December 2019 to February 2020 were retrieved from four databases. We statistically analyzed the clinical symptoms and laboratory results of COVID‐19 patients and explained the discharge rate and fatality rate with a single‐arm meta‐analysis. The available data of 1994 patients in 10 literatures were included in our study. The main clinical symptoms of COVID‐19 patients were fever (88.5%), cough (68.6%), myalgia or fatigue (35.8%), expectoration (28.2%), and dyspnea (21.9%). Minor symptoms include headache or dizziness (12.1%), diarrhea (4.8%), nausea and vomiting (3.9%). The results of the laboratory showed that the lymphocytopenia (64.5%), increase of C‐reactive protein (44.3%), increase of lactic dehydrogenase (28.3%), and leukocytopenia (29.4%) were more common. The results of single‐arm meta‐analysis showed that the male took a larger percentage in the gender distribution of COVID‐19 patients 60% (95% CI [0.54, 0.65]), the discharge rate of COVID‐19 patients was 52% (95% CI [0.34,0.70]), and the fatality rate was 5% (95% CI [0.01,0.11]).