bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reliability and validity of the RS14 in orphaned and separated adolescents and youths in western Kenya
Authors: Sutherland Sarah C. , Shannon Harry S. , Ayuku David , Streiner David L. , Saarela Olli , Atwoli Lukoye , Braitstein Paula 
Published: November 2020

Purpose
The 14-item Resilience Scale (RS14) is a tool designed to measure psychological resilience. It has been used effectively in diverse populations. However, its applicability is largely unknown for Sub-Saharan adolescent populations and completely unknown for orphaned and separated adolescents and youths (OSAY), a highly vulnerable population for whom resilience may be critical. This study assesses the RS14’s psychometric properties for OSAY in Uasin Gishu County, Kenya.

Methods
Survey responses from a representative sample of 1016 OSAY (51.3% female) aged 10–25 (mean = 16; SD = 3.5) living in institutional and home-based environments in Uasin Gishu County were analyzed. The RS14’s psychometric properties were assessed by examining internal consistency reliability, confirmatory factor analyses, and convergent validity using correlations between resilience and each of social support and depression. Sub-analyses were conducted by age and sex.

Results
Resilience scores ranged from 14–98 (mean = 66; SD = 19) with no sex-based significant difference. Resilience was higher for those aged ≥18 (mean = 69; range = 14–98) versus age <18 (mean = 65; range = 14–98). Internal consistency was good (Cronbach’s α = .90). Confirmatory factor analysis indicated a 1-factor solution, though the model fit was only moderate. Resilience was positively correlated with social support in all ages (.22; p < .001) and negatively correlated with depression in individuals age <18 (-.22; p < .001). The relationship between resilience and depression in individuals age ≥18 was statistically significant only in females (-.17; p = .026).

Conclusion
This study demonstrates reasonable evidence that the RS14 is both valid and reliable for measuring psychological resilience in the population of OSAY in western Kenya.
Long-term healthcare provider availability following large-scale hurricanes: A difference-in-differences study
Authors: Bell Sue Anne , Klasa Katarzyna , Iwashyna Theodore J. , Norton Edward C. , Davis Matthew A. 
Published: November 2020

Background
Hurricanes Katrina and Sandy were two of the most significant disasters of the 21st century that critically impacted communities and the health of their residents. Despite the assumption that disasters affect access to healthcare, to our knowledge prior studies have not rigorously examined availability of healthcare providers following disasters.

Objective
The objective of this study was to examine availability of healthcare providers following large-scale hurricanes.

Methods
Using historical data on healthcare providers from the National Plan and Provider Enumeration System and county-level population characteristics, we conducted a quasi-experimental study to examine the effect of large-scale hurricanes on healthcare provider availability in the short-term and long-term. We separately examined availability of primary care physicians, medical specialists, surgeons, and nurse practitioners. A difference-in-differences analysis was used to control for time variant factors comparing county-level health care provider availability in affected and unaffected counties the year before Hurricanes Katrina and Sandy, to five years after each storm.

Results
Counties affected by Hurricane Katrina compared to unaffected locales experienced a decrease of 3.59 primary care physicians per 10,000 population (95% CI: -6.5, -0.7), medical specialists (decrease of 5.9 providers per 10,000 (95% CI: -11.3, -0.5)), and surgeons (decrease of 2.1 (95% CI: -3.8, -0.37)). However, availability of nurse practitioners did not change appreciably. Counties affected by Hurricane Sandy exhibited less pronounced changes. Changes in availability of primary care physicians, nurse practitioners, medical specialists, and surgeons were not statistically significant.

Conclusion
Large-scale hurricanes appear to affect availability of healthcare providers for up to several years following impact of the storm. Effects vary depending on the characteristics of the community. Primary care physicians and medical specialists availability was the most impacted, potentially having long-term implications for population health in the context of disaster recovery.
Tissue Systems Pathology Test Objectively Risk Stratifies Barrett's Esophagus Patients With Low-Grade Dysplasia
Authors: Frei Nicola F. , Khoshiwal Amir M. , Konte Kadere , Bossart Emily A. , Stebbins Katelyn , Zhang Yi , Pouw Roos E. , ten Kate Fiebo J.W. , Seldenrijk Kees A. , Meijer Sybren L. , Critchley-Thorne Rebecca J. , Bergman Jacques J.G.H.M. 
Published: November 2020

INTRODUCTION:
Low-grade dysplasia (LGD) is the best predictor of neoplastic progression in Barrett's esophagus (BE). Most LGD cases are downstaged to nondysplastic (ND) BE on expert pathologist review, which is prone to interobserver variation and not widely available. Recent studies indicate that a risk prediction assay (TissueCypher) risk stratifies patients with NDBE for neoplastic progression. We aimed to investigate whether this risk prediction assay predicts neoplastic progression in BE patients with LGD.

METHODS:
A blinded, retrospective cohort study was derived from the screening cohort of a randomized controlled trial of SURveillance vs RadioFrequency ablation for BE patients with LGD. Hematoxylin and eosin and p53 immunohistochemistry slides from the first endoscopy with LGD were independently reviewed by 3 expert pathologists and tested by the risk prediction assay. Revision diagnoses of NDBE were considered low risk, although indefinite for dysplasia, and LGD were considered high risk for progression.

RESULTS:
A total of 155 BE patients (123 men), mean age 61 ± 10 years, were analyzed. Thirty-four patients (22%) progressed to high-grade dysplasia/esophageal adenocarcinoma (median time 2.4 years) and 121 did not progress (median high-grade dysplasia/esophageal adenocarcinoma-free surveillance 7.9 years). The risk prediction assay sensitivity was 68% vs 76% for the 3 pathologists, and specificity was 79% vs 64%–77.0% for the pathologists. The assay detected 50%–56% of progressors that were downstaged to NDBE by the pathologists.

DISCUSSION:
The risk prediction assay provided significant risk stratification in BE patients with LGD and identified progressors that the experts downstaged to NDBE. This objective assay provides an effective solution to the lack of standardization of expert pathology review of LGD.
Gerçekliğin Toplumsal İnşasında Bilgi ve Bilgi Merkezi
Authors: Yılmaz Bülent 
Published: November 2020

Gerçeklik, insandan bağımsız olarak varolan, toplumsal olarak yapılandırılan kendinde nesneler dünyasıdır ve insanların onun hakkındaki bilgileri kadar değişkendir. Söz konusu gerçeklik hakkında bize açıklama getirecek bilgimiz yoksa gerçeklik de yoktur. “Bilgi süreçlerinin başarısı” biçiminde tanımlanabilecek toplumsal gerçeklik bize gösterildiği ölçüde vardır. Gerçeklik, bilgi ile yapılandırılan, anlamlandırılan ve iletilen bir olgudur.
Bu çalışmada, toplumsal gerçekliğin oluşturulmasında bilgi ve bilgi taşıyıcısı olarak bilgi merkezinin (kütüphane, arşiv dokümantasyon merkezi vb.) işlevleri irdelenmektedir. Gerçekliğin oluşturulmasında bilgi merkezinin toplumsal işlevi, “bildiğimden ötede gerçeklik yoktur; benim bilmediğim gerçeklik, gerçeklik değildir” varsayımı üzerine temellendirilmektedir. Çalışmada, bilginin ve onun aracısı olarak bilgi merkezinin “gerçekliğe varlık kazandıran ve onu anlamlandıran” rolü bilgi yönetimi alanının kuramsal yapısı açısından değerlendirilmiştir. Yapılan değerlendirmede “Bilgi merkezi önemlidir!” önermesi konu bağlamında temellendirilmeye çalışılmıştır.
MODELOS DE SÉRIES TEMPORAIS: A ANÁLISE DA ACURÁCIA DAS PREVISÕES DA DEMANDA DE UMA LINHA DE PRODUTOS EM EMPRESA DO SETOR DO VESTUÁRIO
Authors: Chiba Guilherme Issao , Luna Mônica Maria Mendes 
Published: November 2020

Objetivo – O objetivo deste artigo é comparar o desempenho de métodos de previsão de séries temporais para uma linha de produtos de uma empresa de vestuário com base na acurácia das previsões. Metodologia – Este artigo apresenta um estudo de caso em uma grande empresa de vestuário. Diferentes métodos foram usados para obter dados quantitativos e qualitativos. Os dados qualitativos foram usados, principalmente, para descrever o processo de previsão de demanda e os quantitativos para fazer previsões. Três modelos de séries temporais foram aplicados e uma análise da acurácia das previsões feita usando diferentes medidas de erro. Resultados – Dos três modelos de séries temporais usados, o método estático é indicado para a linha de produtos considerada, principalmente quando se considera o impacto dos erros de previsão sobre os custos de manutenção e de rupturas de estoques. Também são identificadas vantagens dos métodos quantitativos e analisada a acurácia das previsões, buscando destacar a importância desse procedimento na escolha do modelo. Contribuições – Poucos estudos descrevem detalhadamente o uso de métodos quantitativos, especialmente descrevendo o processo de previsão e a análise dos erros. Este artigo descreve a aplicação de três modelos de séries temporais para prever a demanda da principal linha de produtos de uma grande empresa brasileira de confecções. Além disso, sugere como analisar o impacto dos erros de previsão nas decisões relativas aos estoques e enfatiza a importância da previsão para apoiar as decisões gerenciais, tema raramente abordado na literatura. Palavras-chave - Previsão de demanda. Séries temporais. Método estático. Modelo de Winter.
Effectiveness of Flow Sheet Implementation on Diabetes Progression Screening at a Student-Run Free Clinic
Authors: Wilcox Samuel , Okut Hayrettin , Badgett Robert , Hassouneh Stephanie , Ablah Elizabeth 
Published: November 2020

Introduction: Diabetes mellitus (DM) disproportionately affects people with low socioeconomic-status (SES). Student-run free clinics (SRFC) aim to care for low SES populations and experience high clinician turnover. Flow sheets have been used to improve care for those with diabetes, yet no research has assessed the use of such a flow sheet in a SRFC. The aim of this project was to determine if use of a flow sheet improved care for people with DM in an SRFC.

Methods: Charts from all patients receiving care for DM at one SRFC in the year before (n=53) and after (n=56) implementation of the flow sheet were reviewed. Pre and post group comparisons and post subgroup comparisons were made for glycosylated-hemoglobin (HgbA1c), microalbumin, and foot and eye exams.

Results: During a one-year period, a larger proportion of patients who received care post flow sheet introduction received at least two HgbA1c tests (53%), a microalbumin test (46%), and a foot-exam (46%) compared to those receiving care before the flow sheet (28%, 2%, and 25%, respectively). There was no difference in proportions of patients undergoing eye exams. In post subgroup analysis, flow sheets were used for 50% of patients, and patients who received care with the flow sheet were more likely to receive at least two HgbA1c tests and a foot exam per year.
Conclusions: Our study suggests that flow sheets can improve the process of care for patients with diabetes in a SRFC. A systematic integration of the flow sheet is being implemented in the SRFC now.
Penerapan Arsitektur Neo-Vernakular pada Bangunan Buday dan Hiburan
Authors: Widi Chaesar , Prayogi Luthfi 
Published: November 2020

Arsitektur neo–vernakular adalah salah satu konsep dari aliran post modern. Neo-vernakular adalah gabungan dari dua konsep yang berbeda yaitu modern dan vernakular. Neo–vernakular adalah interpretasi dari arsitektur vernakular. Bangunan budaya dan hiburan adalah salah satu bangunan yang banyak menggunakan konsep neo–vernakular dikarenakan adanya budaya tradisional didalamnya. Penelitian ini dilakukan untuk mengetahui penerapan arsitektur neo–vernakular pada bangunan budaya dan hiburan. Penelitian ini menggunakan metode deskriptif kualitatif. Penelitian ini diharapkan dapat mendeskripsikan penerapan arsitektur neo-vernakular pada bangunan budaya dan hiburan. Penelitian ini mempunyai satu studi kasus yaitu Rumah Keramik F. Widiyanto. Penelitian ini menggunakan ciri – ciri arsitektur neo–vernakular sebagai cara menganalisis studi kasus. Penelitian ini menyimpulkan saung angklung udjo menerapkan lima ciri arsitektur neo-vernakular..
KONSEP INTEGRASI STASIUN LRT BEKASI TIMUR DENGAN KAWASAN MIXED-USE LRT CITY BEKASI TIMUR
Authors: Anissa Indira Nur , Saladin Agus , Rahmah Nuzuliar 
Published: November 2020

Kawasan mixed-use yang berada diluar Jakarta (kota satelit) dapat menjadi alternatif bagi penduduk DKI untuk menetap atau melakukan kegiatan sehingga kepadatan kota Jakarta dapat menurun. Kawasan dengan berbagai fungsi didalamnya seperti hunian, perkantoran dan perdagangan dapat berlangsung dengan baik apabila antar bangunannya dapat terintegrasi dengan baik dan dapat memberikan mobillitas dan aksesibilitas yang baik bagi pengguna kawasan untuk menuju pusat kota Jakarta. Tujuan dari dibuatnya penulisan ini untuk mengetahui serta menganalisa konsep integrasi antara kawasan mixed-use LRT City Bekasi Timur dengan stasiun LRT Bekasi Timur. Penelitian dilakukan dengan metode pendekatan perancangan dengan mengembangkan suatu situasi dengan kreatifitas dan menghasilkan suatu penyelesaian berupa karya perancangan.Berdasarlan hasil analisis, konsep integrasi antara stasiun LRT Bekasi Timur dengan kawasan Mixed-use LRT City adalah melalui jembatann penghubung, karena mempertimbangkan letak stasiun yang berada 20 meter dari permukaan tanah. Jembatan menghubungkan stasiun dengan bangunan sekitar khususnya pada area komersial dan area perkantoran, yaitu bangunan Lifestyle mall, Kantor dan park n ride. Jembatan penghubung didesain ramah bagi penyandang disabilitas dan melindungi pengguna dari panas dan hujan karena tertutup pada bagian atas tetapi tetap dapat melihat kesekitar kawasan pada bagian kanan kirinya.
Effect of the exosome-mediated suppression of the estrogen signaling: the role in the progression of the hormonal resistance of breast cancer cells
Authors: Sorokin D. V. , Andreeva O. E. , Mikhaevich E. I. , Shchegolev Yu. Yu. , Scherbakov A. M. , Gudkova M. V. , Krasil’nikov M. A. 
Published: November 2020

The most effective treatment of the hormone-dependent breast cancer is based on the antiestrogens SERM and aromatase inhibitor treatment, however its efficiency is limited by the acquired resistance to the drugs.Previously we have revealed the effect of the transferring of the hormonal resistance from the resistant to the sensitive cells under in vitro cell co-cultivation, and demonstrated exosomes involvement in this process. Here we have shown that the exosomes of the resistant cells caused the marked inhibition of the estrogen signaling in the recipient cells, and identified microRNAs – ERα suppressors that overexpressed in the resistant exosomes.Taken together, the results obtained demonstrate the important role of the estrogen signaling suppression in the exosome-induced transferring of the hormonal resistance, and revealed the involvement of the exosomal microRNA in the ERα down-regulation.
Asymptomatic intestinal helminth co-infection among pulmonary tuberculosis patients in urban Surabaya: a preliminary study
Authors: Kusumaningtyas Rifat Nurwita , Tantular Indah Setyawati , Kusumaningrum Deby , Kusumaratna Rina K 
Published: November 2020

BACKGROUNDPulmonary tuberculosis (TB) is a leading cause of morbidity and mortality, and East Java province is the second largest contributor of co-infection in Indonesia. Asymptomatic helminth infection among pulmonary tuberculosis patients causes another public health problem. Few data relate to helminth infection based on clinical and immunological outcomes of pulmonary TB in highly endemic areas.
METHODSThis study was designed as a preliminary study and aimed to determine helminth co-infection among TB patients with a macroscopic assessment. This cross-sectional study was conducted in June-August 2017.
RESULTSAmong 16 treated active TB patients from TB cohort data of Tanakali Kedinding health center found that 56% were stool smear-positive for Trichuris trichiura eggs, but had no clinical symptoms.
CONCLUSIONWhether or not the helminth infection may have an impact on the diagnosis and treatment of active TB remains to be further investigated. Co-infection could be inhibited by the host immune response and improve the prognosis of TB treatment.
Machine Learning Methods for Prediction of Hospital Mortality in Patients with Coronary Heart Disease after Coronary Artery Bypass Grafting
Authors: Geltser B. I. , Shahgeldyan K. J. , Rublev V. Y. , Kotelnikov V. N. , Krieger A. B. , Shirobokov V. G. 
Published: November 2020

Aim To compare the accuracy of predicting an in-hospital fatal outcome for models based on current machine-learning technologies in patients with ischemic heart disease (IHD) after coronary bypass (CB) surgery.Material and methods A retrospective analysis of 866 electronic medical records was performed for patients (685 men and 181 women) who have had a CB surgery for IHD in 2008–2018. Results of clinical, laboratory, and instrumental evaluations obtained prior to the CB surgery were analyzed. Patients were divided into two groups: group 1 included 35 (4 %) patients who died within the first 20 days of CB, and group 2 consisted of 831 (96 %) patients with a beneficial outcome of the surgery. Predictors of the in-hospital fatal outcome were identified by a multistep selection procedure with analysis of statistical hypotheses and calculation of weight coefficients. For construction of models and verification of predictors, machine-learning methods were used, including the multifactorial logistic regression (LR), random forest (RF), and artificial neural networks (ANN). Model accuracy was evaluated by three metrics: area under the ROC curve (AUC), sensitivity, and specificity. Cross validation of the models was performed on test samples, and the control validation was performed on a cohort of patients with IHD after CB, whose data were not used in development of the models.ResultsThe following 7 risk factors for in-hospital fatal outcome with the greatest predictive potential were isolated from the EuroSCORE II scale: ejection fraction (EF) <30 %, EF 30-50 %, age of patients with recent MI, damage of peripheral arterial circulation, urgency of CB, functional class III-IV chronic heart failure, and 5 additional predictors, including heart rate, systolic blood pressure, presence of aortic stenosis, posterior left ventricular (LV) wall relative thickness index (RTI), and LV relative mass index (LVRMI). The models developed by the authors using LR, RF and ANN methods had higher AUC values and sensitivity compared to the classical EuroSCORE II scale. The ANN models including the RTI and LVRMI predictors demonstrated a maximum level of prognostic accuracy, which was illustrated by values of the quality metrics, AUC 93 %, sensitivity 90 %, and specificity 96 %. The predictive robustness of the models was confirmed by results of the control validation.Conclusion The use of current machine-learning technologies allowed developing a novel algorithm for selection of predictors and highly accurate models for predicting an in-hospital fatal outcome after CB.
DÜZENLEYİCİ ODAKLARIN DEĞİŞİME DİRENÇ ÜZERİNDEKİ ETKİSİNDE ÖRGÜTSEL İLETİŞİMİN ARACI ROLÜ
Authors: YENER Serdar 
Published: November 2020

Bu çalışmada, düzenleyici odakların değişime direnç
üzerindeki etkisinde örgütsel iletişimin aracı rolü sorgulanmıştır. Düzenleyici
uyum kuramı çerçevesinde oluşturulan araştırma modelinde çalışanların yönelimci
veya kaçınmacı düzenleyici odak
düzeylerinin değişime direnç üzerinde
farlı etkileri olabileceği düşünülmüştür. Bu etkinin salt düzenleyici odaklar
ile açıklanamayacağı örgütsel iletişimin bu etkide gizli değişken (aracı rol)
olarak rol oynayabileceği düşünülmüştür. Bu düşünceden hareketle çalışanların
yönelimci düzenleyici odakları arttıkça örgütsel iletişim üzerinden
değişime dirençlerinin azalacağı, kaçınmacı düzenleyici odakları arttıkça değişime
dirençlerinin artacağı düşünülmektedir. Bu kapsamda öncelikle yönelimci ve
kaçınmacı düzenleyici odaklar, değişime direnç ve örgütsel iletişim kavramlarına ilişkin kavramsal çerçeveye yer
verilmekte, daha sonra, araştırma bölümünde yapılan anket uygulamasına yönelik
bulgu ve sonuçlar sunulmaktadır. Sinop ili Boyabat ilçesinde faaliyet gösteren
bir üretim işletmesinin 146 çalışanı araştırmanın örneklemini oluşturmaktadır.
Araştırma kapsamında kullanılan ankette 5’li likert tipi ölçek tercih
edilmiştir. Yüz yüze anket yöntemi ile elde edilen verilerin analizinde SPSS 21.0
ve Process 3.0 makrosu kullanılarak analiz edilmiştir. Araştırma bulguları sonucunda; örgütsel
iletişimin hem yönelimci hem de kaçınmacı düzenleyici odakların değişime direnç
üzerindeki etkisinde tam aracılık rolü gözlenmiştir.
Knowledge, attitude and practice study about HPV and its vaccination among medical college students in North India
Authors: Kumar Amit , Garg Paridhi 
Published: November 2020

Background: Cervical cancer is one of the most important cancers in women. Cervical cancer is primarily caused by sexually transmitted human papilloma virus (HPV) infection. It has been proven that HPV vaccination, preferably before initiation of sexual life, is highly effective in HPV and cervical cancer prevention. So, this study was conducted to study the knowledge, attitude and practice about the significance of HPV and its vaccination among medical students. Methods: This was a cross-sectional observational study conducted in a medical college. 200 medical students were requested to fill a questionnaire which covered demographic details, knowledge, attitude and practice towards HPV vaccination for cervical cancer prevention. Results: Majority of the students knew that HPV may cause cancer in humans (94%), leading to cervical cancer in females (84.5%) and about the availability of its vaccine in India (79%). But only a few students were aware that it may even lead to cancer in males (52.5%), knew the correct dosing schedule (60%) and that even vaccinated female may develop cancer (36.5%). 74.5% considered its vaccine to be safe, 71.5% considered it effective and 68% considered it protective against sexual partner. Only 33.5% were vaccinated but 92.5% said that they would recommend HPV vaccine to their family. Conclusions: Though the knowledge and attitude about the significance of HPV and its vaccination is good among the medical college students, but the practice of vaccination is poor.