bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic obstructive pulmonary disease in patients with coronary heart disease of elderly age groups
Authors: Voinarovska G.P. , Asanov E.O. 
Published: October 2020

Background. Among the combinations of comorbid conditions, a special role belongs to the combination of coronary heart disease (CHD) and chronic obstructive pulmonary disease (COPD). Because COPD is often associated with CHD, most authors believe that there is a direct link between COPD, progression of bronchial obstruction, and pathological conditions of the cardiovascular system, including mortality from myocardial infarction. In elderly patients, according to some researchers, the link between COPD and CHD is most pronounced.
Objective. To establish the frequency of COPD in patients with CHD in older age groups.
Materials and methods. The studies are based on the results of a comprehensive survey of 635 patients with CHD aged 60-89 years, who were observed for a long time of the State Institution “Chebotarev Institute of Gerontology of the National Academy of Medical Sciences of Ukraine”.
Results and discussion. The share of patients with CHD in whom COPD was detected in the group of elderly people is 19.4 %. This is much more than the average population. The frequency of COPD in patients with CHD decreases significantly with further aging. The prevalence of COPD among elderly patients is much lower than among elderly patients. This can most likely be explained by the fact that a significant proportion of patients with CHD with COPD do not live to old age. The analysis revealed that in elderly patients there is bronchial obstruction of more severe stages. This is due to the fact that CHD patients with COPD who live to old age have worsening bronchial patency due to the longer duration of the disease. It has been established that the majority of patients with CHD with COPD, both elderly and senile, are male. This can be explained by the negative effects of smoking.
Conclusions. The incidence of COPD in patients with CHD in the elderly is much higher than in the population. At the same time, the incidence of COPD among patients with CHD in the elderly is much lower than among the elderly. In patients of advanced age bronchial obstruction is more expressed.
Tactics of infusion therapy in patients with acute cerebral circulatory disorders in the prehospital stage
Authors: Goldovsky B.M. , Serikov K.V. , Potalov S.A. , Serikov V.I. , Filimonova I.V. , Leluk D.V. 
Published: October 2020

Objective. To streamline the tactics of infusion therapy in patients with acute cerebrovascular accident (ACVA) in the prehospital stage.
Materials and methods. A retrospective, non-randomized study of 49 patients with ACVA who received emergency medical care in the prehospital phase.
Results and discussion. Ensuring adequate brain perfusion in the area of ischemia is the main task of emergency medical care ACVA in the prehospital stage (Zozulya I.S., Volosovets A.O.,  Zozulya A.I.  et al., 2019). Among the drugs that effectively improve blood circulation to the brain in the area of ischemia, an important place is occupied by infusion solutions (Semenenko A.I., Kobeliatskyi Yu.Yu., Kondratskyi B.O. et al., 2016). The choice of the optimal qualitative and quantitative composition of infusion solutions in patients with ACVA is one of the most difficult issues of treatment (Halushko O.A., 2017). Infusion therapy for patients with ACVA in the prehospital stage was used according to the Unified Clinical Protocol of Medical Care “Ischemic stroke (emergency, primary, secondary (specialized) medical care, medical rehabilitation)” (Order of the Ministry of Health of Ukraine from 03.08.2012 № 602) according to the following algorithm: 1) providing venous access by standard venous catheterization procedure with asepsis/antiseptics by intravenous catheter № 18; 2) carrying out infusion therapy by introducing 0,9 % sodium chloride solution at a rate of 100 ml×h-1; 3) the introduction of colloidal solutions in patients with ACVA in the prehospital stage was not carried out.
Conclusions. The choice of the optimal qualitative and quantitative composition of infusion solutions in patients with ACVA in the prehospital stage is one of the most difficult issues of emergency care. After providing venous access by catheterization of the peripheral vein with a catheter № 18 infusion therapy is carried out by administering 0,9 % sodium chloride solution at a rate of 100 ml×h-1. The introduction of colloidal solutions in patients with acute cerebral circulatory disorders in the prehospital stage is contraindicated.
Antibiotics using in Georgia: clinical and epidemiological features
Authors: Korinteli I. , Javakhadze M. , Pagava K. 
Published: October 2020

Background. High incidence and lethality of infectious disease is an actual problem of the 21st century medicine. Infectious diseases are one of the most common causes of morbidity worldwide. Untreatable bacterial infections with the current available antibiotics lead to increased morbidity and mortality. Antimicrobials are the most commonly prescribed drugs in the community and hospital setting. However, inappropriate use of antibiotics in recent years has particularly increased the number of antibiotic-resistant strains. Antimicrobial resistance is a significant global health threat. Without effective antimicrobials, much of the progress made in fighting infectious disease would be lost. The recent rise in resistance to these critical medicines is therefore extremely worrisome.
Objective. To study epidemiological and clinical aspects of antibiotics using in Georgia.
Materials and methods. The study was retrospective-prospective. We used ATC/DDD methodology for epidemiological research of antibiotic using in the country and it held 2011-2019. According to this methodology, we calculate defined daily doses of antibiotics per 1000 inhibitors (DID). The point prevalence survey was performed in 2017-2019 in Georgian hospitals for clinical research.
Results and discussion. In last year increased antibiotic using in Georgian population. The lowest rate was in 2014 (19 DID) and the highest in 2019 (37 DID). The most commonly used antibiotics in Georgia are ceftriaxone, amoxicillin / clavulanic acid, azithromycin and ciprofloxacin. Frequency of antibiotic treatment in Georgian hospitals ranges between 77.6 % (2017) and 86.1 % (2019). The use of third generation cephalosporin ranges between 61.9 % (2017) and 59.6 % (2019). From the clinical aspects of antibiotic therapy, it is noteworthy that prevalence of antibiotic using in Georgian clinics is high and ranged from 77.6 % (2017) to 86.1 % (2019). Antibacterial prophylactic decreased and ranged from 38.3 % (2017) to 20.3 % (2019). Antibiotic selection according to guidelines on the most frequent nosology ranges between 73.8 % (2017) and 69.2 % (2019). Empirical antibiotic therapy decreased in last years and ranges between 92.2 % (2017) and 69.2 % (2019).
Conclusions. Increasing rate of antibiotic using in Georgian population and high use of broad-spectrum antibiotics in remarkable. In hospitals, antibiotics are prescribing according to the national or intra hospital guidelines, but there prevalence rate is high. Patient histories included information about general criteria of starting antibiotic therapy. Stop or review date of antibiotic treatment after 72 h in poorly presented. We think that it is very important to continue epidemiological and clinical research for future. Also update or developed new guidelines will be perfect way for optimization.
Optimization of infusion-transfusion therapy in patients with traumatic brain injury
Authors: Nasirova R.I. , Fatullaeva А.А. 
Published: October 2020

Objective. Intensive therapy of severe traumatic brain injury belongs to the most difficult section of resuscitation. Therefore, the main purpose of intensive care during the implementation is to eliminate disorders of Rheosorbilact homeostasis.
Materials and methods. We analyzed 30 patients with traumatic brain injury in the intensive care unit of the Republican Clinical Hospital between 2018 and 2019. All patients were divided into two groups: 1st – control group (16 patients) – received complex intensive therapy without Rheosorbilact, while 2nd group (14 patients), received Rheosorbilact in a comprehensive intensive therapy. The main pharmacologically active substances of the drug are sorbitol, basic cations (Na, K, Ca, Mg), and sodium lactate. Thanks to these components, the drug has a hyperosmolar effect, causing fluid from the intercellular space to enter the vascular channel and thus improves microcirculation and perfusion of brain tissue. In order to monitor the effectiveness of the therapy in the dynamics evaluated indicators of hemodynamics (level of consciousness and diuresis), laboratory data (hemotocrit, electrolyte composition of blood, acid-alkaline blood condition, coagulogram), and MRI data. Rheosorbilact was used as part of a complex therapy in an infusion-transfusion program in the amount of 200-400 ml daily intravenous drip.
Results. In patients, whom after the beginning of complex intensive therapy was included Rheosorbilact, was observed earlier (the first 6 h) compared to the control group, which did not use Rheosorbilact, stabilization of hemodynamics.
Conclusions. Infusion therapy with Rheosorbilact in patients with traumatic brain injury contributed primarily to stabilization of hemodynamics and faster normalization of vital functions of the body.
Massive obstetric bleeding: optimization of total hysterectomy surgery technique and conservative treatment
Authors: Niyazmetov R.E. , Matyakubov B.B. , Nazarov B.B. , Usinova Z.B. 
Published: October 2020

Objective. Reducing maternal mortality during massive obstetric bleeding (MOB) through optimizing total hysterectomy technique and improving the quality of infusion therapy.
Materials and methods. The analysis and evaluation of the results of MOB treatment in a comparative aspect were carried out in retrospective and prospective groups from 2014 to 2019 in Urgench perinatal center and three maternity complexes of Khorezm region, Uzbekistan. The retrospective group included 72 pregnant women with an average blood loss of 2450.0±80.0 ml, while the prospective group included 78 pregnant women with an average blood loss of 2530.0±70.0 ml.
Results and discussion. 1,419 (6.2 %) cases out of 22,896 deliveries in the retrospective group were accompanied by abnormal blood loss, and the MOB frequency of more than 1500.0 ml was determined in 0.3 % of all deliveries. 5 (62.5 %) of 8 cases of maternal mortality were directly related to MOB. In the retrospective group, a total hysterectomy was performed using traditional method for MOB, with an interoperable blood loss of 860.0±110.0 (p<0.05). Qualitative and quantitative composition of infusion therapy in this group averaged: saline sodium chloride solution 4350,0±350.0; Heloplasm (INN) -500,0±100,0; hydroxyethylated starch 1800.0±150.0; Rheosorbilact 400.0±50.0 and fresh frozen plasma (FFP) 1650.0±110.0. Optimized version of total hysterectomy in a prospective group differs from the traditional with one “hemostatic suture” imposed on all three formations (fallopian tube, own and round ligament). Imposed first in the distal, then proximal, and on descending and ascending departments a. uterinae during the operation. The optimized version of total hysterectomy resulted in reduction of interoperative blood loss by an average of 340.0±60.0 ml in MOB and reduction of operation time by 22.0±4.0 min, thereby improving the outcome of the operation. Amount of saline sodium chloride solution was injected in average by 1900.0; Refortan by 600.0; FFP by 230.0 less, and INN, Gelofuzin by 500.0 and Rheosorbilact by 400.0 more in the prospective group than in the retrospective group.
Conclusions. Optimized version of total hysterectomy with improved qualitative and quantitative composition of infusion therapy for MOB contributed to reduction of maternal mortality by 19.7 % in the prospective group compared to the retrospective group.
The experience of L-arginine using in placental insufficiency
Authors: Safarova S.S. , Aliyeva E.M. , Abbasova F.Yu. , Mirzoyeva Kh.M. 
Published: October 2020

Objective. To evaluate the effectiveness of the use of L-arginine in the treatment of placental insufficiency (PI) in pregnant women.
Materials and methods. We examined 49 pregnant women with PI at 22-34 weeks of gestation. The women were divided into two groups. The 1st group included 27 patients who, as part of the standard complex treatment, were injected intravenously with L-arginine (Tivortin®, “Yuria-Pharm”, Ukraine) 4.2 % solution for infusion at a dose of 100 ml a day for 5 days. The 2nd group included 22 women in which standard basic therapy was used for PI treatment. To study the state of the fetoplacental complex in the blood serum of pregnant women, the level of human placental lactogen (hPL) and free estriol (E3) was determined by direct competitive enzyme immunoassay (ELISA).
Results and discussion. All patients included in the study were comparable in somatic and obstetric status. The age of pregnant women in both groups ranged from 22 to 39 years, averaging 26±3.2 years in the 1st and 31±2.4 years in the 2nd group. The level of hPL before therapy was reduced in 10 (37.03 %) patients in the 1st group and in 8 (29.62 %) patients in the 2nd group. The concentration of free E3 was reduced in 12 (44.44 %) patients of the 1st group and in 9 (40.9 %) patients of the 2nd group. In the main group, the average concentration of free E3 was 18.8±13.3 ng/ml, and the hPL was 7.1±2.6 mg/L. In the comparison group, the level of free E3 averaged 19.1±10.2 ng/ml and hPL was 6.9±3.9 mg/L. After adjustment of PI in all patients of the 1st group, and in 19 (86.36 %) of the 2nd group, the concentration of hPL and free E3 corresponded to the norm. Thus, in the main group, the average concentration of free E3 was 22.7±14.1 ng/ml, and the hPL was 8.1±2.9 mg/L. In the comparison group, the level of free E3 averaged 22.1±14.6 ng/ml and hPL – 8.3±3.9 mg/L. Only in 3 (13.63 %) patients of the comparison group, the level of hormones was still reduced.
Conclusions. The inclusion of L-arginine (Tivortin) in therapeutic regimens in order to correct placental dysfunction leads to a regression of fetoplacental circulatory disorders and reduces the risk of unfavorable perinatal outcomes.
Prospects of infusion therapy in the treatment of severe pulmonary tuberculosis in combination with COVID-19
Authors: Todoriko L.D. , Gumeniuk M.I. , Semianiv I.O. , Sprynsian T.A. , Denysov O.S. 
Published: October 2020

Background. Clinical experience has shown that in conditions of severe quarantine, patients with small respiratory syndromes do not have access to early and quality differential diagnosis. It increases the risk of hospitalization, in such cases, to the infectious department. In most cases, tuberculosis (TB) treatment is no different in people with coronavirus disease (COVID-19).
Objective. Analyze the outlook for the effects of the interaction between COVID-19 and TB, which remains the leading cause of death from a single infectious disease in the world, and for the reduce the risk of TB infection in a pandemic without losing treatment.
Results and discussion. Recently, patients with TB and COVID-19 syntropy, which requires off-label therapy, have to be treated more and more often. This is especially true for patients with diabetes who are at risk for both TB and coronavirus infection. In such cases, which account for approximately 10-15 % of the total, oral therapy (per os) has a high risk of being ineffective. Timely infusion therapy for the synthesis of infectious diseases – TB and COVID-19 – reduces the risk of lethal prognosis. The method of intravenous infusions of anti-TB drugs is the ability to quickly create very high concentrations of drugs in the pulmonary artery, bypassing the liver as the main organ of inactivation and presystemic metabolism. Experience with co-treatment of COVID-19 and TB remains limited. However, suspension of TB treatment in patients with COVID-19 should be exceptional. Prophylactic treatment of TB, treatment of drug-sensitive or resistant TB should be continued continuously to protect the patient’s health, reduce transmission of infection and prevent the development of drug resistance. Therapeutic trials and accumulation of practical experience are underway. However, there are currently no warnings regarding the interaction of drugs used in the treatment of COVID-19 and anti-TB drugs, including the use of infusion therapy in severe conditions.
Conclusions. Timely infusion therapy for the synthesis of infectious diseases – TB and COVID-19 – reduces the risk of lethal prognosis.
Investigation of sorption capacity of dye-affinity sorbents in the process of purification of factor VIII coagulation
Authors: Shurko N.O. , Danysh T.V. 
Published: October 2020

Background. Chromatographic methods, in particular affinity chromatography, are the most effective in obtaining highly purified preparations of plasma proteins. The active triazine and vinyl sulfone dyes are the special group of ligands for affinity chromatograph. We found that the dye-affinity sorbents bind non-target to factor VIII (FVIII) proteins in the previous stages of the study. The sorption capacity of the affinity sorbent is defined as the maximum amount of sample (protein) that can bind to the column under certain conditions. Determining the adsorption limit or limiting capacity of the sorbent makes it possible to identify the feasibility of its use to extract a certain type of protein.
Objective. To study the sorption capacity of various dye-ligand affinity sorbents in the process of purification of FVIII.
Materials and methods. We used next sorbents: Diasorb-Procion Blue HB, Diasorb-Procion Gelb M4R and Diasorb-Procion Blue MXR. The cryoprecipitate was initial material. The total protein concentration was determined by the Bradford method, the activity of factors VIII – one-stage clotting method.
Results and discussion. Sorption of non-target proteins and FVIII activity were investigated after preparation of a number of dilutions of the initial solution of cryoprecipitate. Different concentrations of protein were applied per 1 cm3 of sorbent to select the optimal concentration and do not to oversaturate the column: I – 19.74±0.20 mg of protein/ml; II – 7.94±0.05 mg of protein/ml; III – 3.97±0.05 mg of protein/ml; IV – 1.96±0.04 mg of protein/ml. The maximum sorption capacity among the studied sorbents was 14.62±0.04 mg of protein / 1 cm3 for of sorbent Diasorb-Procion Blue HB. It was found that to achieve maximum purification of FVIII (highest specific activity), the optimal concentration of protein to 1 ml of sorbent should be in the range of 4-8 mg of protein / 1 cm3 of sorbent. The highest degree of purification for these sorbents was 19.65 times at an initial protein concentration of about 4 mg protein/ml (p≤0.01).
Conclusions. The sorption capacity of sorbents was calculated. It was demonstrated that the maximum sorption capacity is approximately 15 (14.62±0.04) mg of protein / 1 cm3 of sorbent.
Interactive Letter and Number Learning Machines For Early Childhood
Authors: Wicaksono Mochamad Fajar , Rahmatya Myrna Dwi , Rinaldi Angga 
Published: October 2020

The purpose of this study is to design and create interactive learning machines for letters and numbers for early childhood. The machine designed is an interactive learning machine so that early childhood is interested in learning and can learn independently. Arduino Mega2560 is used as the main processor on this machine. On this machine, there are three modes, namely learning mode, question mode, and counting mode. In learning mode, Arduino will read every button input pressed, display on the LCD and make a sound through DF Player in accordance with the input received. In the question mode, Arduino will issue a question in the form of sound and wait for an answer via the input button found on the device. In arithmetic mode, Arduino will read the input of 10 LDR sensors covered by ice-cream sticks placed by young children and make sounds related to the amount. Questions on tools can be changed by using an android application designed in this study. Based on the test results, this tool has been running well where all modes can be run 100% whether it is learning mode, question mode, and counting mode.
Keyword— Arduino, Early childhood, LCD, DF Player, Letters, and Numbers, Counting
Frequency of Birth Defects in a Tertiary Care Hospital in Bangladesh
Authors: Amin Tahsinul , Pervez Mehdi , Nur Ayesha Najma 
Published: October 2020

Background: Birth defects usually present at birth and may cause morbidity and mortality in the newborn. These defects may involve any organ system of the body. Gradually the incidence is rising due to various etiologies. The objective of the study was to find out the frequency, types and etiology of birth defects.
Materials & Methods: This cross-sectional study was done in a tertiary care hospital in Bangladesh. In this study, 100 neonates with birth defects were enrolled, thoroughly examined, investigated and evaluated. Then collected data were analyzed.
Results: The frequency of birth defects in this study was 1.54%. The most frequent birth defect was club foot deformity i.e. 11% and the most frequently involved organ system was cardiovascular system i.e. 28%. Among the birth defects 78% were major and only 22% were minor. Among those children with birth defect mortality was 17%; 41% were referred to advanced center and 42% were improved and discharged. In some of the cases with birth defect chromosomal anomaly, congenital infection (TORCH), maternal diabetes was found as causing factor.
Conclusion: The frequency of birth defects was found 1.54% and most of the birth defects were major defect. Club foot deformity was found as the most common birth defect.
Bangladesh J Child Health 2020; VOL 44 (1) :8-12
Cornelia de Lange Syndrome A Case Report
Authors: Karim Muhammad Rezaul , Begum Suraiya , Shamaly Kohinoor Jahan , Zannat Ismot Ara 
Published: October 2020

Cornelia de Lange syndrome (CdLS) is a rare syndrome of multisystem disorder. Almost every system is involved in this disorder having growth retardation, facial dysmorphism, short stature, psychomotor delay and behavioral problems. Diagnosis is made on the basis of clinical observations, physical examination, laboratory tests and X-rays; chromosome analysis is usually conducted before a diagnosis is made. DNA testing is helpful for confirmation of the clinical diagnosis. A 10 year old boy presented with short stature, facial dysmorphism, microcephaly, mental retardation and micromelia. DNA analysis revealed heterozygous mutation in NIBPL gene. Patient was counseled about the diagnosis and treatment was given. We reported the case due to rarity of the disease.
Bangladesh J Child Health 2020; VOL 44 (1) :52-54