bluuebunny/crossref_metadata_2025_split huggingface dataset:
Percutaneous trans-ulnar versus trans-radial arterial approach for coronary angiography and angioplasty, a preliminary experience at an Egyptian cardiology center
Authors: Shafiq Mohammad , Mahmoud Hesham Boushra , Fanous Malak Lamie 
Published: September 2020

AbstractBackgroundTrans-ulnar approach was proposed primarily for elective procedures in patients not suitable for trans-radial approach that was introduced two decades ago. The trans-ulnar approach is as safe and effective as the trans-radial approach for coronary angiography and intervention.AimThis study’s aim was to assess the feasibility and safety of the trans-ulnar approach in coronary procedures as a preliminary experience for operators experienced in trans-radial approach with no/minimal trans-ulnar approach experience at an Egyptian center.ResultsVascular access in 120 patients was selected randomly for coronary angiography and angioplasty—80 through radial and 40 through ulnar approach. Patients were examined for local complications and Doppler evaluation to both radial and ulnar arteries a day after the procedure was done. Ulnar approach success was 82.5% versus 93.7% in the radial group; failure of ulnar artery puncture was the only cause of crossover in the ulnar group, while occurrence of persistent spasm was the leading cause of crossover in the radial group followed by radial artery tortuosity. The procedure time of coronary angiography and percutaneous coronary intervention of the ulnar group was significantly higher than that of the radial group (Pvalue = 0.011 and 0.034, respectively). The mean caliber of the right ulnar artery was 2.45 ± 0.38, slightly larger than that of the radial artery 2.33 ± 0.38 at the level of the wrist, but this difference was statistically non-significant.ConclusionOur study demonstrated that ulnar access with experienced radial operators and in our patients is a safe and practical approach for coronary angiography or angioplasty, without any major complications. Bearing in mind its high success rate, it can be used when a radial artery is not useful for the catheterization or as a default approach on the expense of slightly longer procedural time.
The reliability and validity of the Arabic version of the Mouth Handicap in Systemic Sclerosis (MHISS) Questionnaire in Arabian systemic sclerosis patients
Authors: Elattar Enas A. , Balata Mona G. , El Mallah Reem 
Published: September 2020

Abstract
Background
Systemic sclerosis (SSc) is an autoimmune multi-systemic disease with predominant affection of connective tissue. Skin is characteristically affected in SSc and is almost responsible for oral complications as well as aesthetic changes which affect the patient’s oral health-related quality of life. The Mouth Handicap in Systemic Sclerosis (MHISS) Questionnaire is the first tool to subjectively calculate the handicap associated with mouth disability in SSc patients. This study aimed to test for reliability, the validity of the Arabic version of the MHISS to be used in Arabian systemic sclerosis.

Results
This study was conducted on 38 females with SSc with a mean age of 48.7 ± 5.01 years and a mean disease duration of 6.23 ± 3.14 years—18 patients (47.4%) have diffuse SSc while 20 (52.6%) have localised SSc. The mean value of the total MHISS for SSc patients was 12.21 ± 3.51, test–retest reliability of the Arabic version was excellent (ICC = 0.991) with excellent internal consistency (Chronbach’s α = 0.892) with significant negative correlation with mouth opening (r = − 0.512, p < 0.05) and no correlation with the Health Assessment Questionnaire Disability Index (HAQ-DI).

Conclusion
Our results demonstrated that the Arabic version of the MHISS questionnaire had excellent test–retest reliability and very good validity in measuring mouth disabilities in Arabian SSc patients.
GFI1 functions to repress neuronal gene expression in the developing inner ear hair cells
Authors: Matern Maggie S. , Milon Beatrice , Lipford Erika L. , McMurray Mark , Ogawa Yoko , Tkaczuk Andrew , Song Yang , Elkon Ran , Hertzano Ronna 
Published: September 2020

ABSTRACT
Despite the known importance of the transcription factors ATOH1, POU4F3 and GFI1 in hair cell development and regeneration, their downstream transcriptional cascades in the inner ear remain largely unknown. Here, we have used Gfi1cre;RiboTag mice to evaluate changes to the hair cell translatome in the absence of GFI1. We identify a systematic downregulation of hair cell differentiation genes, concomitant with robust upregulation of neuronal genes in the GFI1-deficient hair cells. This includes increased expression of neuronal-associated transcription factors (e.g. Pou4f1) as well as transcription factors that serve dual roles in hair cell and neuronal development (e.g. Neurod1, Atoh1 and Insm1). We further show that the upregulated genes are consistent with the NEUROD1 regulon and are normally expressed in hair cells prior to GFI1 onset. Additionally, minimal overlap of differentially expressed genes in auditory and vestibular hair cells suggests that GFI1 serves different roles in these systems. From these data, we propose a dual mechanism for GFI1 in promoting hair cell development, consisting of repression of neuronal-associated genes as well as activation of hair cell-specific genes required for normal functional maturation.
An HIV-Tat inducible mouse model system of childhood HIV-associated nephropathy
Authors: Tang Pingtao , Das Jharna R. , Li Jinliang , Yu Jing , Ray Patricio E. 
Published: September 2020

ABSTRACT
Modern antiretroviral therapies (ART) have decreased the prevalence of HIV-associated nephropathy (HIVAN). Nonetheless, we continue to see children and adolescents with HIVAN all over the world. Furthermore, once HIVAN is established in children, it is difficult to revert its long-term progression, and we need better animal models of childhood HIVAN to test new treatments. To define whether the HIV-1 trans-activator (Tat) gene precipitates HIVAN in young mice, and to develop an inducible mouse model of childhood HIVAN, an HIV-Tat gene cloned from a child with HIVAN was used to generate recombinant adenoviral vectors (rAd-Tat). rAd-Tat and LacZ control vectors (2×109) were expressed in the kidney of newborn wild-type and HIV-transgenic (Tg26) FVB/N mice without significant proteinuria (n=5; 8 per group). Mice were sacrificed 7 and 35 days later to assess their renal outcome, the expression of HIV-genes and growth factors, and markers of cell growth and differentiation by RT-qPCR, immunohistochemistry and/or western blots. HIV-Tat induced the expression of HIV-1 genes and heparin-binding growth factors in the kidney of HIV-Tg26 mice, and precipitated HIVAN in the first month of life. No significant renal changes were detected in wild-type mice infected with rAd-Tat vectors, suggesting that HIV-Tat alone does not induce renal disease. This new mouse model of childhood HIVAN highlights the critical role that HIV-Tat plays in the pathogenesis of HIVAN, and could be used to study the pathogenesis and treatment of HIVAN in children and adolescents.
Design and Pricing of Discretionary Service Lines
Authors: Debo Laurens , Li Cuihong 
Published: September 2020

For discretionary services, longer service duration implies higher service quality. We study the optimal design and pricing of discretionary service lines, a range of services that are vertically differentiated through their duration (quality), offered to a market with customers who are heterogeneous in terms of their sensitivity to service duration. In a resource-constrained environment with stochastic arrival of demand, longer service duration also implies longer wait, which all customers dislike. Hence, service line design takes into consideration both customer heterogeneity in quality sensitivity and customer disutility in waiting. We first study the case when the firm serves customers in the order they arrive (first in first out (FIFO)). Then we investigate a processing-time-based sequencing rule with two priority classes (two classes shortest processing time (2-SPT)) as a practical operational improvement of FIFO. We identify service variety reduction as an instrument to mitigate congestion, in addition to service time reduction and throughput control used for discretionary service design. Although FIFO results in a range of closely related service durations and an increasing price schedule, we show that 2-SPT gives rise to a clustered service line with a gap between the ranges of service durations offered for different priority classes, along with a decrease of demand volume and a possible price drop from the lower-quality to the higher-quality cluster. Finally, even without customer heterogeneity, it is still optimal for the firm to offer a variety of services under 2-SPT, driven by operational efficiency improvement, whereas under FIFO the service line collapses to a single service. This paper was accepted by Terry Taylor, operations management.
Charge Characteristics and Cation Exchanges Properties of Hilly Dryland Soils Aceh Besar, Indonesia
Authors: Sufardi Sufardi , Arabia Teti , Khairullah Khairullah , Karnilawati Karnilawati , Sahbudin Sahbudin , Zainabun Zainabun 
Published: September 2020

Soil surface charge and cation exchange are important parameters of soil fertility in tropical soils. This study was conducted to investigate characteristics of surface charges and cation exchanges on four soil orders of the dryland in Aceh Besar district. The soil order includes Entisols Jantho (05o16’58.41” N; 95o37’51.82” E), Andisols Saree (05o27'15.6" N; 95o44'09,1" E), Inceptisols Cucum (05º18’18,37” N; 95º32’48,04” E), dan Oxisols Lembah Seulawah (05o27’19,4” N; 95o46’19,2” E). The charge characteristics of surface charge are evaluated from the parameter of DpH (pHH2O-pHKCl), variable charge (Vc), permanent charge (Pc), and point of zero charges (PZC). In contrast, cation exchange properties are evaluated from several soil chemical properties, such as soil organic matter (SOM), base saturation (BS), cation exchange capacity (CEC), and effective CEC (ECEC). The results show that the four pedons of soil in the hilly dryland of Aceh Besar include a variable charge because it has a PZC, which is characterized by a negative surface charge with a PZC of pHH2O and has CEC dependent soil pH. PZC value varies from 3.21 – 5.26 and sequentially PZC Andisols Oxisols Entisols Inceptisols. The total CEC value differs considerably from ECEC and the sum of cations. CEC total of the soils varies from 12.8 – 34.4 cmol kg-1, whereas the ECEC values vary from 2.72 – 8.66 cmol kg-1. The highest variable charge percentage is found in Andisols Saree. In contrast, the highest permanent charge is found in Inceptisols Cucum and is positively correlated with pHH20, PZC, CEC, and sums of cations or ECEC. Improving soil quality in hilly dryland soils in Aceh Besar District can be done by decreasing the PZC status of soils with organic amendments and fertilizers or increasing the pH by using liming.
Theoretical analysis of large negative dispersion photonic crystal fiber with small confinement loss
Authors: Rahaman Md. Ekhlasur , Hossain Md. Mahbub , Shekhar Mondal Himadri , Saha Rekha , Saif Muntaseer Ahmed 
Published: September 2020

Solid core circular and octagonal photonic crystal fibers (CPCF and OPCF) are proposed for analyzing different guiding properties such as dispersion, effective mode area, nonlinearity, and confinement loss from 0.8 to 2.6 µm wavelength. The proposed structures use three different types of background materials: SF10, BK7, and silica. Moreover, the fill fraction is varied by changing the diameter of the air hole where the lattice pitch is unchanged. The proposed PCFs show a high negative dispersion with low confinement loss and small effective mode area. In the proposed design, the finite element method with a perfectly matched layer absorbing boundary condition is used. At 1.8 µm wavelength with 0.6 fill fraction, the maximum negative dispersion of

−

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is observed for CPCF when the background material is SF10. In addition, at this particular wavelength, the confinement loss is observed to be very small. Moreover,

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dispersion is found for the similar condition at 1.55 µm wavelength. On the other hand, using BK7 as the background material,

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dispersion is found at 1.55 µm wavelength for CPCF. Results also imply that CPCF shows better performance than OPCF for a wide wavelength range. Furthermore, at 1.55 µm wavelength, silica-based glass exhibits maximum dispersion, whereas increasing wavelength flint type glass shows the similar result. Analyzing different guiding properties of PCFs has significant impact on broadband dispersion compensation applications, especially using SF10.
VECSEL-based virtually imaged phased array spectrometer for rapid gas phase detection in the mid-infrared
Authors: Rockmore Robert , Gibson Ricky , Moloney Jerome V. , Jones R. Jason 
Published: September 2020

We present a novel, to the best of our knowledge, system for high-resolution, time-resolved spectroscopy in the mid-wave infrared based on a modelocked vertical external cavity surface emitting laser (VECSEL) frequency comb coupled to a virtually imaged phased array (VIPA) spectrometer. The GHz level repetition rate of VECSEL-based systems coupled to VIPA spectrometers enables comb tooth resolved spectra without the use of additional filter cavities often required to increase comb tooth spacing. We demonstrate absorption spectroscopy on a methane (

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4

) gas mixture at

2900

c
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(3.4 µm) with over

35

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spectral bandwidth in a single image. Rapid time-resolved measurements were made using a 300 µs exposure time with an acquisition rate limited to 125 Hz by the available camera. High-resolution absolute frequency measurements were performed by scanning the repetition rate of the VECSEL frequency comb.
Optimal column layout for hybrid workloads
Authors: Athanassoulis Manos , Bøgh Kenneth S. , Idreos Stratos 
Published: September 2020

Data-intensive analytical applications need to support both efficient reads and writes. However, what is usually a good data layout for an update-heavy workload, is not well-suited for a read-mostly one and vice versa. Modern analytical data systems rely on columnar layouts and employ delta stores to inject new data and updates.
We show that for hybrid workloads we can achieve close to one order of magnitude better performance by tailoring the column layout design to the data and query workload. Our approach navigates the possible design space of the physical layout: it organizes each column's data by determining the number of partitions, their corresponding sizes and ranges, and the amount of buffer space and how it is allocated. We frame these design decisions as an optimization problem that, given workload knowledge and performance requirements, provides an optimal physical layout for the workload at hand. To evaluate this work, we build an in-memory storage engine, Casper, and we show that it outperforms state-of-the-art data layouts of analytical systems for hybrid workloads. Casper delivers up to 2.32x higher throughput for update-intensive workloads and up to 2.14x higher throughput for hybrid workloads. We further show how to make data layout decisions robust to workload variation by carefully selecting the input of the optimization.
Secure multi-party functional dependency discovery
Authors: Ge Chang , Ilyas Ihab F. , Kerschbaum Florian 
Published: September 2020

Data profiling is an important task to understand data semantics and is an essential pre-processing step in many tools. Due to privacy constraints, data is often partitioned into silos, with different access control. Discovering functional dependencies (FDs) usually requires access to all data partitions to find constraints that hold on the whole dataset. Simply applying general secure multi-party computation protocols incurs high computation and communication cost.
This paper formulates the FD discovery problem in the secure multi-party scenario. We propose secure constructions for validating candidate FDs, and present efficient cryptographic protocols to discover FDs over distributed partitions. Experimental results show that solution is practically efficient over non-secure distributed FD discovery, and can significantly outperform general purpose multi-party computation frameworks. To the best of our knowledge, our work is the first one to tackle this problem.
An end-to-end learning-based cost estimator
Authors: Sun Ji , Li Guoliang 
Published: September 2020

Cost and cardinality estimation is vital to query optimizer, which can guide the query plan selection. However traditional empirical cost and cardinality estimation techniques cannot provide high-quality estimation, because they may not effectively capture the correlation between multiple tables. Recently the database community shows that the learning-based cardinality estimation is better than the empirical methods. However, existing learning-based methods have several limitations. Firstly, they focus on estimating the cardinality, but cannot estimate the cost. Secondly, they are either too heavy or hard to represent complicated structures, e.g., complex predicates.
To address these challenges, we propose an effective end-to-end learning-based cost estimation framework based on a tree-structured model, which can estimate both cost and cardinality simultaneously. We propose effective feature extraction and encoding techniques, which consider both queries and physical operations in feature extraction. We embed these features into our tree-structured model. We propose an effective method to encode string values, which can improve the generalization ability for predicate matching. As it is prohibitively expensive to enumerate all string values, we design a patten-based method, which selects patterns to cover string values and utilizes the patterns to embed string values. We conducted experiments on real-world datasets and experimental results showed that our method outperformed baselines.
A meta-analysis of tumor necrosis factor-α-308 G>A polymorphism in gastric cancer
Authors: Jiang Xin , Naikoo Niyaz Ahmad , Gao Shuowei 
Published: September 2020

Abstract

Background
Gastric cancer (GC) is the common cause of cancer-related deaths worldwide and inflammation represents the early phases in the GC.

Objective
To review the tumor necrosis factor (TNF)-α-308 G>A (GG, GA, and AA) in GC by meta-analysis studies for any differences in TNF-α-308 G>A gene polymorphisms.

Methods
Case–control studies published from 2003 to 2017 were identified by searching PubMed, EMASE, and the Internet with the English language. The analysis published on TNF-α-308 G>A polymorphism was analyzed and a limited number of articles were included in the present study. TNF-α-308 G>A from 4,157 patients and 5,185 healthy controls was evaluated. Studies were evaluated using Cochrane Q-test and publication bias was evaluated by constructing funnel plots.

Results
Overall, TNF-α-308 GA genotype showed significant association [P < 0.0001, odds ratio (OR), 95% confidence interval (CI) = 0.82 (0.74–0.91)]. However, meta-analysis of TNF-α-308 genotypes (GG, GA, AA, and GA + AA) between GC patients and controls showed nonsignificant association with GC [P > 0.05, recessive model: OR = 1.38, 95% CI: 1.15–1.66; dominant model: OR = 1.23, 95% CI: 1.09–1.39; (G/A) vs. (G/G): OR = 1.15, 95% CI: 1.02–1.28; (A/A) vs. (G/G): OR = 1.44, 95% CI: 1.19–1.73]. Analysis stratified by ethnicity showed same results in Asian and Caucasian populations.

Conclusions
Results revealed nonsignificant association of TNF-α-308 genotypes (GG, GA, AA, and GA + AA) and GC. TNF-α-308GA genotype showed significant association whereas homozygous genotype AA did not show association with GC risk.
Clinical features and immunohistochemistry profile of biopsy-proven gastric gastrointestinal stromal tumor (GIST): a description of 5 years case series and literature review of GIST
Authors: Ongprakobkul Chuthamas , Rattanachaisit Pakkapon , Kwankajonwong Nachchakorn , Werawatganon Duangporn , Klaikaew Naruemon , Rerknimitr Rungsun 
Published: September 2020

Abstract

Background
Gastrointestinal stromal tumor (GIST) was the most common mesenchymal tumor of the gastrointestinal tract predominately occurring in the stomach. Although GIST was a rare disease, it was considered to be a life-threatening malignancy.

Objective
To explore the current status of gastric GIST in Thai patients.

Method
The medical records of patients who were diagnosed with histologically proven gastric GIST from 2012 to 2016 in King Chulalongkorn Memorial Hospital were reviewed.

Results
Of 22 patients, there were 14 (63.6%) females and 8 (36.4%) males with the mean age of 62.6 ± 14.8 years. The average duration before the first presentation was 12 weeks. The initial symptoms were upper gastrointestinal bleeding (50.0%) followed by abdominal pain (31.8%). Tumor mostly located at the proximal part (fundus and cardia) in 20 (90.9%) patients. At the time of the diagnosis, three patients (13.6%) had distant metastasis. Of this group, 77.3% underwent surgical treatment.

Discussion
Although gastric GIST was an uncommon disease, early diagnosis and prompt treatment could save the lives of many patients.
Real-Variable Characterizations of Hardy–Lorentz Spaces on Spaces of Homogeneous Type with Applications to Real Interpolation and Boundedness of Calderón–Zygmund Operators
Authors: Zhou Xilin , He Ziyi , Yang Dachun 
Published: September 2020

AbstractLet (𝒳,d,μ) be a space of homogeneous type, in the sense of Coifman and Weiss, with the upper dimensionω. Assume that η ∈(0, 1) is the smoothness index of the wavelets on 𝒳 constructed by Auscher and Hytönen. In this article, via grand maximal functions, the authors introduce the Hardy–Lorentz spacesH*p,q(𝒳)H_*^{p,q}\left( \mathcal{X} \right)with the optimal rangep∈(ωω+η,∞)p \in \left( {{\omega \over {\omega + \eta }},\infty } \right)andq ∈(0, ∞]. When andp∈(ωω+η,1]p \in ({\omega \over {\omega + \eta }},1]q ∈(0, ∞], the authors establish its real-variable characterizations, respectively, in terms of radial maximal functions, non-tangential maximal functions, atoms, molecules, and various Littlewood–Paley functions. The authors also obtain its finite atomic characterization. As applications, the authors establish a real interpolation theorem on Hardy–Lorentz spaces, and also obtain the boundedness of Calderón–Zygmund operators on them including the critical cases. The novelty of this article lies in getting rid of the reverse doubling assumption ofμby fully using the geometrical properties of 𝒳 expressed via its dyadic reference points and dyadic cubes and, moreover, the results in the caseq ∈(0, 1) of this article are also new even when 𝒳 satisfies the reverse doubling condition.
Avicenna on Mathematical Infinity
Authors: Zarepour Mohammad Saleh 
Published: September 2020

AbstractAvicenna believed in mathematical finitism. He argued that magnitudes and sets of ordered numbers and numbered things cannot be actually infinite. In this paper, I discuss his arguments against the actuality of mathematical infinity. A careful analysis of the subtleties of his main argument, i. e.,The Mapping Argument, shows that, by employing the notion ofcorrespondenceas a tool for comparing the sizes of mathematical infinities, he arrived at a very deep and insightful understanding of the notion of mathematical infinity, one that is much more modern than we might expect. I argue, moreover, that Avicenna’s mathematical finitism is interwoven with his literalist ontology of mathematics, according to which mathematical objects are properties of existing physical objects.