bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical characteristics of IgG4-related retroperitoneal fibrosis versus idiopathic retroperitoneal fibrosis: a retrospective study of 132 patients
Authors: Liu Yanying , Wang Kunkun , Wang Zhenfan , Zeng Qiaozhu , Zhu Lijuan , Gao Jingyuan , Wang Ziqiao , Zhang Yanyan , Zhang Shanshan , Yang Fei , Shen Danhua , Yu Guangyan , Wang Yi , Li Zhanguo 
Published: December 2019

Abstract
Backgroud Retroperitoneal fibrosis (RPF) is a condition characterized by the presence of inflammation and fibrosis in the retroperitoneal space. More than two-thirds of all cases of RPF are idiopathic retroperitoneal fibrosis (IRPF), while the remaining one-third stem from different secondary causes. Many studies suggest that IgG4-related RPF is a secondary form of RPF. We undertook this study to compare detailed demographic, clinical and laboratory characteristics of IgG4-related RPF and IRPF in a large China cohort.Methods We carried out a retrospective review of the medical records of 132 cases of RPF diagnosed at Peking University People’s Hospital between March 2010 and March 2018. We divided the patients into two groups, IgG4-related RPF group and IRPF group. A standardized case report form was used for data collection. All statistical analyses were performed by SPSS 24.0.Results Among the 132 patients, the mean age at disease onset was 54.8 years. IgG4-related RPF group showed greater male predominance compared to IRPF group. IgG4-related RPF patients showed a longer interval between symptom onset and diagnosis, and allergic diseases were more common in this group. Sixty-four patients (48.4%) had lower back pain, which was more common in IRPF group than that in IgG4-related RPF patients. In terms of organ involvement, although 42 of 47 patients (89.3%) with IgG4-related RPF had other organ involvement, there were no patients in the IRPF group with other organ involvement. In addition, the serum IgG4 level, elevated eosinophils counts and IgE level were significantly higher in IgG4-related RPF patients.Conclusions We have revealed demographic, clinical and laboratory differences between IgG4-related RPF and IRPF patients, which indicated potential differences in pathogenesis and important implications for the diagnosis and management of these two phenotypes.
Reactive Case Detection of Asymptomatic Malaria in Households and Neighbors of Laboratory Confirmed Cases in Raya Kobo District, Northeast Ethiopia
Authors: Melese Yimer , abate megbaru alemu , Yimer Mulat , Tegegne Banchamlak 
Published: December 2019

Abstract
Background Malaria is the leading vector borne parasitic disease causing enormously high morbidity and mortality worldwide. There have been huge efforts so far to control and eliminate malaria in the world. However, high prevalence of asymptomatic carriage poses a threat on malaria control and elimination programs. Since asymptomatic infections present no overt sign and symptoms, they do not get clinical attention. Moreover, asymptomatic cases are a potential source of infection in high and low transmission settings. Despite the presence of some pocket data, the prevalence of asymptomatic carriage has not yet been known nationally and the current study area as well. Therefore, we aimed to assess the prevalence of asymptomatic malaria cases and associated factors in households and neighbors of laboratory confirmed cases in Raya Kobo district, Northeast Ethiopia. Methods: A community based cross-sectional study was conducted from February to April, 2019 among 270 study participants selected by convenient sampling technique at the community where laboratory confirmed cases were found. A structured questionnaire was used to collect data on socio-demographic characteristics, individual and household level factors. The data were entered in Epi Data 3.1 version and analyzed by using SPSS version 20. Variables with P<0.25 in the bivariable analysis were taken to the multivariable analysis to control potential confounders, and p< 0.05 was considered statistically significant. Results: The overall prevalence of asymptomatic malaria was 7.0%, with 3.0%, 5.2% and 12.0%, respectively by Rapid diagnostic tests (RDT), Microscopy and Polymerase chain reaction (PCR). Majority of the infections (73.7%) were identified from index households. PCR detected asymptomatic infections about 2.7 and 2.3 folds higher than RDT and microscope, respectively. Previous malaria history (AOR: 4.030, 95% CI: 1.021-15.903), living with index cases (AOR: 3.880, 95% CI: 1.275-11.806) and family size > 6 members (AOR: 4.820, 95% CI: 1.260-18.437) were significant predictors of Plasmodium spp infection.Conclusion: Reactive case detection had identified considerably higher asymptomatic malaria cases at the community. Therefore, active case investigation should be established in the community by tracking the symptomatic cases at the health facilities. Diagnostic tests involving the PCR should be implemented in the surveillance of asymptomatic malaria. Active malaria cases should also be treated.
Supplementation with a bioactive melon concentrate in humans and animals: prevention of oxidative damages and fatigue in the context of a moderate or eccentric physical activity
Authors: Saby Marion , Gauthier Audrey , Barial Sandy , Egoumenides Laure , Jover Bernard 
Published: December 2019

Abstract

Background: Physical activity is recognized to provide both physical and psychological health benefits. However, oxidative stress can occur in case of poor adaptation to effort and reduce training effectiveness inducing muscular and joint damages. SOD B® M is a melon concentrate, well known to counteract oxidative stress and prevent its side effects. The present study aimed to evaluate the potential of the melon concentrate in the context of both a strong and isolated effort associated with deleterious effects, and a moderate and regular physical activity considered as beneficial. Methods: First, a preclinical study was set up on Sprague Dawley rats to evaluate the effect of the melon concentrate on the prevention of damages induced by an eccentric exercise. Secondly, the combined effect of the melon concentrate and a regular standardized physical training was studied on the overall physical condition of healthy subjects in a randomized, double-blind, placebo-controlled trial. Repeated measures ANOVA, student’s t test and Mann-Whitney test were used for statistical analyses. Results: Melon concentrate helped to prevent gastrocnemius damages induced by the eccentric exercise. It allowed a reduction of fibrosis by approximately 38 % and a reduction of TNF-α plasma level by 28 %. This supplementation also induced a rearrangement of myosin fibers and an increase in PGC-1α plasma level. In the clinical study, melon concentrate was able to decrease oxidative stress and CRP plasma level. Besides, magnesium (Mg) plasma level was higher in the context of a regular training performed by healthy subjects supplemented with the melon concentrate. Conclusions: Melon concentrate was able to prevent damages generated during an eccentric exercise. It also allowed a better adaptation to effort linked to PGC-1α activation: a regulator of energy metabolism. The antioxidant properties of the melon concentrate and its ability to mobilize Mg also suggest that the supplementation could induce a better endurance and resistance to fatigue during regular physical activity.
Sarıkeçili Yörük Dokumalarının Renk Kontrastlıkları Açısından Tasarım Kurgusunun İncelemesi
Authors: Kodal Tuğba , Genç Mustafa 
Published: December 2019

Öz

Isparta ve çevresi iklimi, bitki örtüsü, yaylaları ve göç
yolları güzergâhında olmasından dolayı Yörük yaşamı ve buna bağlı olarak dokuma
kültürü açısından zengin bir yöredir. Osmanlı ve Cumhuriyet dönemindeki iskân faaliyetleriyle
Yörükler yerleşik hayata geçirilmiş, birçoğu yarı konar-göçer olmuştur.
Yerleşim tercihleri önceden yaşadıkları bölgeler olmuştur. Sarıkeçili’ler öncesi
göç yollarından biri olan Isparta ve çevresine yerleşen Yörüklerdendir.
Çalışmada Isparta’da yaşayan Sarıkeçili Yörüklerine ait dokumaların alt anlamı
ya da simgesel okumasına girmeksizin plastik bağlamda çözümlemesi yapılmıştır.
Çözümleme yöntemi temel tasarım ilkeleri düzleminde yer alan renkkontrastlıkları
ve kompozisyon kurguları içerisindeki egemenlik (vurgu) ilişkileri üzerinden
gerçekleştirilmiştir. Şüphesiz dokumaların kendine özgü dillerini belirli
kalıplara sokmak ya da sanat eseri olup olmadıklarını sorgulamak
amaçlanmamıştır. Amacımız; dokumaların
renk seçimlerinin tasarım kurgusuna etkisi nedir? Estetik bir arayış, ortak bir
biçem kaygısı söz konusu mu? Yoksa gelişigüzel bir seçim mi? gibi sorulara
cevap aramaktır. Ayrıca Sarıkeçili Yörüklerine ait 20 dokumada tasarım
ilkelerine uygun bir yapılaşma olup olmadığı sorgulanmıştır.
A Model Proposed for the Prediction of Future Sustainable Residence Specifications Using Analytical Network Process
Authors: Eraqi Ayman M. Zakaria , Shoura Walid Abdul-Hady 
Published: December 2019

In Egypt, people are unable to determine the qualities of appropriate residence that achieves quality and occupant satisfaction, and contributes to sustainability of residential conglomerations. In general, developing countries lack housing information which can be used to enhance quality of residence. Also, the methods of assessing and identifying the appropriate criteria for future residence quality remain traditional ones that cannot address the multiple, conflicting, overlapping aspects to reach a good decision. This calls for using the Analytical Network Process (ANP), an effective tool for specifying the relative importance of all factors impacting a specific issue for making an appropriate residential decision. In addition, this method provides results for the decision element impacts network within the decision structure; thus contributing to more understanding of the mechanisms and requirements of residence selection. The proposed decision structure comprises a two-level network: main clusters, main elements, and sub-elements included in the demographic characteristics group, the residence criteria group, the demand parameters group, the supply parameters group, the residence specifications group, and the alternatives group which representing, in total, the decision and specifying the percentage needed for each housing level. Results of the model showed complete capacity in smoothly addressing complexities and overlapping in the decision structure. The decision structure showed that 52% chose luxury residence, 28% chose middle-class residence, and 19.5% chose the economic residence. Mechanisms of decision making were analyzed; particularly in terms of relationship to demographic characteristics and residence specifications. Also, the importance and impact of demand / supply parameters in reaching decision were analyzed.
Groundwater budget deficit caused by drought and overexploitation
Authors: Soleimani-Motlagh Mahdi , Ghasemieh Hoda , Talebi Ali , Abdollahi Khodayar , Dragoni Walter 
Published: December 2019

Abstract
Groundwater is generally influenced by overexploitation and climatic stresses particularly in arid and semi-arid areas of the world. The present research was conducted to identify the relative contribution of drought and overexploitation to groundwater budget deficit in an unconfined aquifer system. In order to simulate groundwater, the simulated recharge from WetSpass-M model was applied in the MODFLOW model along with other required packages. Moreover, the groundwater budget deficit caused by stressors was quantified through the use of calibrated groundwater model predictions. In order to better understand how the stressors affect the groundwater deficit, the aquifer was divided into Clusters 1, 2, and 3. Locally, the results showed that the contribution of stressors to groundwater budget deficit was the highest in Cluster 1 due to the groundwater overexploitation and quick reaction of the groundwater level to the droughts. Overall, this research showed that both drought and overexploitation, with an average of 2.44 and 3.32 million cubic meters, respectively, played a significant role in groundwater storage deficit. Furthermore, the effect of groundwater overexploitation was approximately 36% more than droughts.
Urban water demand assessment for sustainable water resources management, under climate change and socioeconomic changes
Authors: Alamanos Angelos , Sfyris Stamatis , Fafoutis Chrysostomos , Mylopoulos Nikitas 
Published: December 2019

Abstract
The relationship between water abstraction and water availability has turned into a major stress factor in the urban exploitation of water resources. The situation is expected to be sharpened in the future due to the intensity of extreme meteorological phenomena, and socio-economic changes affecting water demand. In the city of Volos, Greece, the number of water counters has been tripled during the last four decades. This study attempts to simulate the city's network, supply system and water demand through a forecasting model. The forecast was examined under several situations, based on climate change and socio-economic observations of the city, using meteorological, water pricing, users' income, level of education, family members, floor and residence size variables. The most interesting outputs are: (a) the impact of each variable in the water consumption and (b) water balance under four management scenarios, indicating the future water management conditions of the broader area, including demand and supply management. The results proved that rational water management can lead to remarkable water conservation. The simulation of real scenarios and future situations in the city's water demand and balance, is the innovative element of the study, making it capable of supporting the local water utility.
Potential Therapeutic Approaches to Alzheimer’s Disease By Bioinformatics, Cheminformatics And Predicted Adme-Tox Tools
Authors: Avram Speranta , Mernea Maria , Limban Carmen , Borcan Florin , Chifiriuc Carmen 
Published: December 2019

Background:
Alzheimer’s disease (AD) is considered a severe, irreversible and progressive
neurodegenerative disorder. Currently, the pharmacological management of AD is based on a
few clinically approved acethylcholinesterase (AChE) and N-methyl-D-aspartate (NMDA) receptor
ligands, with unclear molecular mechanisms and severe side effects.

Methods:
Here, we reviewed the most recent bioinformatics, cheminformatics (SAR, drug design,
molecular docking, friendly databases, ADME-Tox) and experimental data on relevant structurebiological
activity relationships and molecular mechanisms of some natural and synthetic compounds
with possible anti-AD effects (inhibitors of AChE, NMDA receptors, beta-secretase, amyloid
beta (Aβ), redox metals) or acting on multiple AD targets at once. We considered: (i) in silico
supported by experimental studies regarding the pharmacological potential of natural compounds as
resveratrol, natural alkaloids, flavonoids isolated from various plants and donepezil, galantamine,
rivastagmine and memantine derivatives, (ii) the most important pharmacokinetic descriptors of
natural compounds in comparison with donepezil, memantine and galantamine.

Results:
In silico and experimental methods applied to synthetic compounds led to the identification
of new AChE inhibitors, NMDA antagonists, multipotent hybrids targeting different AD processes
and metal-organic compounds acting as Aβ inhibitors. Natural compounds appear as multipotent
agents, acting on several AD pathways: cholinesterases, NMDA receptors, secretases or Aβ, but
their efficiency in vivo and their correct dosage should be determined.

Conclusion:
Bioinformatics, cheminformatics and ADME-Tox methods can be very helpful in the
quest for an effective anti-AD treatment, allowing the identification of novel drugs, enhancing the
druggability of molecular targets and providing a deeper understanding of AD pathological mechanisms.
Anticholinesterase Activity of Cinnamic Acids Derivatives: In Vitro, In Vivo Biological Evaluation, and Docking Study
Authors: Ghafary Shahrzad , Nadri Hamid , Mahdavi Mohammad , Moradi Alireza , Akbarzadeh Tahmineh , Sharifzadeh Mohammad , Edraki Najmeh , Moghadam Farshad Homayouni , Amini Mohsen 
Published: December 2019

Background:Acetylcholine deficiency in the hippocampus and cortex, aggregation of amyloid-beta, and beta-secretase overactivity have been introduced as the main reasons in the formation of Alzheimer’s disease.Objective:A new series of cinnamic derived acids linked to 1-benzyl-1,2,3-triazole moiety were designed, synthesized, and evaluated for their acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activities.Methods:Colorimetric Ellman’s method was used for the determination of IC50% of AchE and BuChE inhibitory activity. The kinetic studies, neuroprotective activity, BACE1 inhibitory activity, evaluation of inhibitory potency on Aβ1-42 self-aggregation induced by AchE, and docking study were performed for studying the mechanism of action.Results:Some of the synthesized compounds, compound 7b-4 ((E)-3-(3,4-dimethoxyphenyl)-N-((1- (4-fluorobenzyl)-1H-1,2,3-triazole-4-yl) methyl) acrylamide) depicted the most potent acetylcholinesterase inhibitory activities ( IC50 = 5.27 μM ) and compound 7a-1 (N- ( (1- benzyl- 1H- 1, 2, 3- triazole - 4-yl) methyl) cinnamamide) demonstrated the most potent butyrylcholinesterase inhibitory activities (IC50 = 1.75 μM). Compound 7b-4 showed neuroprotective and β-secretase (BACE1) inhibitory activitiy. In vivo studies of compound 7b-4 in Scopolamine-induced dysfunction confirmed memory improvement.Conculusion:It should be noted that molecular modeling (compounds 7b-4 and 7a-1) and kinetic studies (compounds 7a-1 and 7b-4) showed that these synthesis compounds interacted simultaneously with both the catalytic site (CS) and peripheral anionic site (PAS) of AChE and BuChE.
Liraglutide Therapy in a Prediabetic State: Rethinking the Evidence
Authors: Papaetis Georgios S. 
Published: December 2019

Background:
Prediabetes is defined as a state of glucose metabolism between normal glucose
tolerance and type 2 diabetes. Continuous β-cell failure and death are the reasons for the evolution
from normal glucose tolerance to prediabetes and finally type 2 diabetes.

Introduction:
The necessity of new therapeutic approaches in order to prevent or delay the development
of type 2 diabetes is obligatory. Liraglutide, a long-acting GLP-1 receptor agonist, has 97% homology
for native GLP-1. Identification of the trophic and antiapoptotic properties of liraglutide in preclinical
studies, together with evidence of sustained β-cell function longevity during its administration
in type 2 diabetes individuals, indicated its earliest possible administration during this disease, or even
before its development, so as to postpone or delay its onset.

Methods:
Pubmed and Google databases have been thoroughly searched and relevant studies were selected.

Results:
This paper explores the current evidence of liraglutide administration both in humans and
animal models with prediabetes. Also, it investigates the safety profile of liraglutide treatment and its
future role to postpone or delay the evolution of type 2 diabetes.

Conclusion:
Liralgutide remains a valuable tool in our therapeutic armamentarium for individuals who
are overweight or obese and have prediabetes. Future well designed studies will give valuable information
that will help clinicians to stratify individuals who will derive the most benefit from this agent,
achieving targeted therapeutic strategies.
Role of Nano-Photocatalysts in Detoxification of Toxic Heavy Metals
Authors: Tahir Muhammad B. , Asiri Abdullah M. , Malik Muhammad F. , Khalid Nadeem R. , Iqbal Tahir , Rafique Muhammad , Kiran Habiba , Muhammad Shabbir , Siddeeg Saifeldin M. , Shahzad Khurram 
Published: December 2019

Background:
Nano-photocatalysis through semiconductor-based materials has become an
emerging and eye-catching approach for detoxification of hazardous heavy metals in the aqueous environment.

Methods:
In this article, photocatalysis, being a green technique along with several other detoxification
technologies for toxic heavy metals, has been reviewed.

:
Furthermore, the adverse effects of heavy metals on human health, agricultural lands, environment,
and aquatic systems were investigated. Toxic heavy-metals contribute to numerous environmental
issues based on their toxicity.

Result:
Various types of photocatalysts have been discussed in recent literature for the detoxification
of heavy metals. The recycling of photocatalysts may be anticipated as a worthy method for
wastewater treatment which is also discussed with recent examples.

Conclusion:
Moreover, it concludes with efficiency, challenges and new future perspectives for
heavy metal detoxification using photocatalysis.
Graphitic Carbon Nitride-based New Advanced Materials for Photocatalytic Applications
Authors: Raizada Pankaj , Kumar Abhinandan , Singh Pardeep 
Published: December 2019

Background:
The present scenario of rapid industrial and population growth has become a
serious threat to environmental and energy concerns. Extremely noxious pollutants like dyes, heavy
metal ions, phenols, antibiotics and pesticides in water are the reason behind deprived water quality
leading to inadequate access to clean water. Photocatalysis is a prominent strategy for environmental
remediation as photocatalytic materials not only convert solar energy into usable energy expedient
but also shows potential application in pollutant mitigation. An effectual photocatalytic system must
possess wide visible absorption range, high physio-chemical firmness, and effective space-charge
separation along with strong redox ability. Polymeric graphitic carbon nitride a metal-free semiconductor
photocatalyst has outshined as a robust photocatalyst for various photocatalytic applications.

Methods:
Hybridizing polymeric g-C3N4 with other semiconductor photocatalysts has not only conquer
the limitations related to pristine g-C3N4 but also displayed improved photoactivity. Different
photocatalytic systems involving g-C3N4 coupled metal-oxides, metal-free systems and complex heterojunction
systems are reviewed. Moreover, an all-embracing study based on g-C3N4 based nanocatalysts
is explored via heterojunction formation taking g-C3N4 as one component.

Results:
Photocatalytic experiments involving photodegradation of pollutants, revealed the significance
of metal-free g-C3N4 in the heterojunction system which remarkably boost the photoactivity
through effective separation and migration of photocarriers. Moreover, from recyclability experiments,
exceptional photostability of g-C3N4 based photocatalysts was observed. Photocatalytic pollutant
degradation is a complex phenomenon which requires significant experimental techniques to
support the mechanism. With the help of photoelectrochemical analysis, the mechanisms behind photodegradation
can be evaluated and explored.

Conclusion:
Metal-free polymeric g-C3N4 is a potential semiconductor photocatalyst which can be
optimally utilized for wastewater treatment. Coupling g-C3N4 with another semiconductor material
with an appropriate band edge can effectively enhance the photocatalytic efficacy. Herein, g-C3N4
derived metal-oxide, metal-free and complex heterojunction systems are explored and their photocatalytic
efficiency is evaluated for pollutant degradation. However, more effective research efforts
are needed for large-scale applications of g-C3N4 based photocatalysts.