bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experience of Hepatocellular Cancer Therapy with Multikinase Inhibitors in the Republic of Bashkortostan
Authors: Gantsev Sh. Kh. , Lipatov O. N. , Menshikov K. V. , Tursumetov D. S. , Saydulaeva Kh. S. 
Published: November 2020

Introduction. Hepatocellular carcinoma (HCC) is the most common primary malignant neoplasm of the liver. During the early stages, HCC is asymptomatic, which makes X-ray examination a particularly important diagnostic tool. According to WHO data, the mortality rate from HCC was 782,000 in 2018. HCC is associated with a number of risk factors: a high viral load, liver cirrhosis, detected HBeAg and elevated serum HBsAg levels. Inhibitors of tyrosine kinase receptors increase the overall survival and progression-free survival rates in patients with metastatic HCC. In this article, we conduct an analysis of results of the REFLECT study obtained for Russian patients by the Republican Clinical Oncological Dispensary, Ufa.Materials and methods. The experimental group included 9 patients (52.9%) receiving Lenvatinib. The control group included 8 patients (47.1%)) underwent therapy with Sorafenib at a dose of 800 mg per day 7 (41.17%) patients had a history of chronic hepatitis, of which hepatitis B and chronic hepatitis C was confirmed in 6 and 1 cases, respectively.Results and discussion. Over the period from 2017 up to the present, progression-free survival was observed in three patients (17.6%), of which 2 and 1 received Lenvatinib and Sorafenib, respectively. Overall survival was 10.5 months. The median overall survival rate in the experimental and control groups was 9.8 and 11.2 months, respectively. These parameters are considered comparable, provided that the sample was small.Conclusions. The use of Lenvatinib demonstrated the efficacy comparable to that of Sorafenib in terms of the overall survival rate in patients with inoperable HCC. Lenvatinib allowed statistically and clinically significant improvement in the progression-free survival and time to progression to be achieved.
Blood taurine concentrations in dogs with exocrine pancreatic insufficiency
Authors: Tayler Sarah , Seo Joonbum , Connolly David J. , Kathrani Aarti 
Published: November 2020

Abstract

OBJECTIVE
To determine whether blood taurine concentrations in dogs with exocrine pancreatic insufficiency (EPI) were lower than the reference interval (200 to 350 nmol/mL) or the cutoff used to indicate taurine deficiency (< 150 nmol/mL).

ANIMALS
18 dogs with clinical or presumptive subclinical EPI with residual blood samples available for taurine concentration analysis.

PROCEDURES
Dogs were classified as having clinical EPI if they had a serum trypsin-like immunoreactivity concentration of < 2.0 μg/L and presumptive subclinical EPI if they had a concentration of 2.0 to 5.0 μg/L. Archived, frozen blood samples stored in EDTA were submitted for measurement of taurine concentration with an automated high-performance liquid chromatography amino acid analyzer. Medical record data were examined for associations with blood taurine concentration.

RESULTS
None of the 18 dogs had a blood taurine concentration < 150 nmol/mL. Two dogs had a concentration < 200 nmol/mL. No clinical signs, physical examination findings, or serum biochemical abnormalities were associated with blood taurine concentration. Eleven of the 17 dogs for which diet histories were available were not receiving a diet that met recommendations of the World Small Animal Veterinary Association Global Nutrition Committee.

CONCLUSIONS AND CLINICAL RELEVANCE
A low blood taurine concentration was noted in a small subset of dogs with EPI. Additional research is needed to determine whether EPI was the primary cause of this low concentration. Findings suggested the importance of obtaining complete diet histories and ensuring dietary requirements are sufficiently met in dogs with EPI. (Am J Vet Res 2020;81:958–963)
Risk Factors for the Occurrence of Desmopathy of the Collateral Ligaments of the Distal Interphalangeal Joint in Equines – A Cross-Sectional Study
Authors: Camargo Góss Geórgia , Desconsi Mozzaquatro Fabricio , Lima Machado Ingrid Rios , Maldonado Gomes Etiele , Salgueiro Da Silva Graziele , Moreira Carneiro Ana Luisa , Belmonte Silveira Bruno , Afonso Rivero Bruno , Acosta Duarte Claudia 
Published: November 2020

Abstract
Desmopathy of the collateral ligaments of the distal interphalangeal joint (CL-DIPJ) has been increasingly relevant in equine sports medicine. However, the risk factors for the development of such desmopathy are not well established. In the literature, what has been described about it, is based on the clinical conditions observed in animals diagnosed with this disorder. Considering this scenario, the aim of this study was to verify which possible extrinsic or intrinsic risk factors may influence the occurrence of disorders in the collateral ligaments of the distal interphalangeal joint in polo horses. Twenty-five horses from the same equestrian team, all competing in polo, were evaluated via ultrasonography. The outcome was defined as changes in echogenicity and/or boundaries of the CL-DIPJ of the thoracic limbs of the horses evaluated. The intrinsic factors considered in this study were age, the presence of angular deviations and gender. As extrinsic factors, the parameters taken into consideration were the handicap in which the animals played and the type of training to which these horses were previously submitted in their professional athletic career. The prevalence ratio was used to verify the association between risk factor and outcome. The result of this evaluation was considered significant when the confidence interval value did not involve the value 1. Positive and significant association was observed only for age. Playing in different handicaps did not influence the presence of ligament disorders. The other factors evaluated revealed a positive but not significant association. Thus, it was concluded that animals aged nine years or older present a higher risk of CL-DIPJ disorders.
The Impact of Double Layer Membrane Technique on Bone Regeneration in Postextraction Alveoli – A Pathohistological Experimental Study in Dogs
Authors: Dejan Dubovina , Marija Bubalo , Branko Mihailović , Zoran Tatić , Darko Marinković , Zoran Bukumirić , Filip Đorđević , Zoran Lazić 
Published: November 2020

Abstract
Post extraction alveolar ridge preservation is a preventive oral surgical procedure aimed to preserve the dimensions of the alveolar ridge after removal of the teeth. According to literature data, the utilization of guided bone regeneration for this purpose is absolutely justified. The aim of this study was to examine the effect of resorbable collagen membranes placed in two layers in respect to the application of membranes placed in one layer to the degree of bone regeneration after a tooth extraction. This experimental study was conducted on six adult dogs. In the first phase all four premolars were extracted on both sides in the lower jaw. After the volume-standardisation with bone drill, three post extraction alveoli were filled with bone substitute of equine origin and then covered with: collagen bioresor bable membrane of porcine origin; collagen bioresorbable membrane of equine origin; pericardial bioresorbable membrane of equine origin. The membranes on the left side were placed in single-layer and on the right side in double-layer manner. After different monitoring periods, histopathological analysis of the samples taken from the experimental regions was performed. A different degree of bone regeneration was achieved between experimental regions in which membranes were placed in one layer and those where membranes were placed in two layers. There was no difference between regions where membranes of different origin were placed in the same manner. The procedure of covering the post extraction alveoli, filled with bone substitute and with resorbable membranes placed in two layers resulted in a higher degree of bone regeneration compared to those where resorbable membranes were placed in one layer.
Observation of Hermann’s Tortoise (Testudo hermanni) C Lutching without the Presence of Males and Eggshell Mortality on a Large Tortoise Farm in Slovenia Over a Three-Year Period
Authors: Mateja Stvarnik , Renata Lindtner-Knific , Žan Štokar , Gordana Gregurić Gračner , Jasna Mićunović , Alenka Dovč 
Published: November 2020

Abstract
The aim of this study was to determine the percentage of hatched and fertilized eggs in female Hermann’s tortoises before and after the removal of males after breeding.
A breeding group of Testudo hermanni boettgeri with 50 females and 12 males was included in the study. In the first year, all adults were together in the same habitat until reproductive activity was observed. After the end of May, the males and females were separated for the next two active seasons. The number of eggs and number of second clutches decreased gradually. In the first year, 76.0% of females laid eggs; in the second year, 24.0%; and in the third year, only 8.0%. Second clutches were observed in ten females (26.3%) in the first year, while in the next two years, one female had a second clutch. There was a small but significant correlation between the weight of a single tortoise and the number of eggs laid but no significant correlation between the weight of the tortoise and its average egg weight. The weight (15.1-16.8 g), length (33.9-36.1 mm) and width of each egg (27.5-28.0 mm) was measured.
During the laying season, the eggs were put into incubators. The incubation length varied from 52 to 70 days. After the end of incubation, eggshell mortality and its causes (19.3-52.5%) were examined. In the first year, the viability rate of the incubated eggs was 80.7%; in the second year, 80.5%; and in the third year, 47.8%. Among the unhatched eggs in the first year, 62.5% were unfertilized, 53.1% were infected, 28.1% were dehydrated and 21.9% were found in various stages of embryonic development.
Urticaria Pigmentosa Due to Microsporum canis Infection in a Sphynx Cat – Case Report
Authors: Marcin Szczepanik , Piotr Wilkołek , Grzegorz Kalisz , Anna Śmiech 
Published: November 2020

Abstract
A two- year-old Sphynx cat, an unneutered female with multiple erythematous papules with hyperpigmentation was presented. In skin biopsy, in the dermis, well differentiated monomorphic mast cells were found. Fungal culture was positive for Microsporum canis. Diagnosis of urticaria pigmentosa following M. canis infection was made. The animal was successfully treated with itraconazole orally and shampoo containing chlorhexidine and miconazole. To the authors’ knowledge, this is the first reported case of urticaria pigmentosa following the dermatophyte infection in a Sphynx cat.
Plyometric Exercises Improves Muscular Power and Digital Achievement in High Jump Among Students
Authors: Houcine Benzidane , Djamel Mokrani , Ahmed Attalah 
Published: November 2020

Summary
The research aim was to identify the effect of using some plyometric exercises to improve muscular power (vertical jump) and digital achievement in high jump activity among third year’s students. The researchers used an experimental method in conformity with research nature between pre-tests and post-tests for the sample research. The sample was formed by students belonging to the physical education and sports institute, University of Mostaganem (Algeria) of the academic year 2018/2019. 40 students were chosen and divided into two groups (experimental 21 students, control 19 students). The vertical jump test of stability and digital achievement test were used. After the treatment of the results by statistical means and through these results, it has been reached several conclusions from them. Plyometric exercises are important to develop vertical jump and digital achievement level in high jump [discussion significant difference (p≤0.05)] among students, and the best improvement of the experimental group based on plyometric exercises is marked comparing to the control group.
Clinical Characteristics of PMS Co-Morbid with MDD and Effectiveness of SSRIs in its Treatment
Authors: Yakimova R. , Stoimenova-Popova M. , Chumpalova P. , Pandova M. , Stoyanova M. 
Published: November 2020

Abstract

Background: Data on the clinical characteristics of premenstrual syndrome (PMS) with co-morbid major depressive disorder (MDD) are scarce. Although selective serotonin re-uptake inhibitors (SSRIs) are widely used to treat both PMS and MDD there is little information on their efficacy in PMS in patients with co-morbid MDD.

Objective: To describe the clinical picture of PMS co-morbid with current depressive episode (DE) and evaluate its dynamics under a 6-month course of SSRIs treatment.

Materials and methods: We present a longitudinal observational study, conducted in out- and inpatient conditions. Thirty-one women eligible to antidepressant treatment for a current DE in the course of MDD were evaluated for PMS and those of them suffering from both conditions were re-evaluated twice during a 6-month medication intake period.

Results: The pre-treatment clinical picture of PMS co-morbid with MDD was dominated by moderately to severely expressed mood swings, anxiety, fatigue, breast tenderness, palpitations, abdominal bloating, and headache. After six months of SSRIs intake the syndrome was characterised by nearly the same symptoms (with the addition of irritability and appetite changes) but mildly expressed.

Conclusion: Untreated PMS co-morbid with MDD is characterised by mainly moderately severe psychological and around three times less commonly – somatic symptoms. SSRIs treatment alleviate both symptom types at month three and even further, although less pronouncedly at month six.
Additive Antidepressant Effects of Combined Administration of Ecitalopram and Caloric Restriction in LPS-Induced Neonatal Model of Depression in Rats
Authors: Haritov E. , Tivcheva J. 
Published: November 2020

Abstract

Background and aims: Increasing evidence indicates that inflammation in the periphery and neuroinflammation in the brain might be involved in the pathophysiology of depressive symptoms in humans. Relatively little is known about the effects of selective serotonin re-uptake inhibitors (SSRI) on individuals exposed to differential dietary regimens, like caloric restriction (CR).
The aim of the current study is to assess the antidepressant and antineuroinflammatory effects of CR in single administration and combined with SSRIsantidepressant escitalopram in LPS-induced model of depression in Wistar rats.

Materials and methods: For this purpose, we used 36 Wistar rats and applied 3 behavioral tests for depression (FST, SPT and NSFT) in animals and an ELISA-method for measurement of brain IL-1beta levels.

Results: Behavioral assessment and results from ELISA-method have shown that CR not only augments the effect of the antidepressant escitalopram on forced swim test (FST) and sucrose preference test (SPT), but also reduces the brain levels of proinflammatory cytokine IL-1beta. Combined with escitalopram, CR enhances antidepressant and antinflamatory properties of this SSRI.

Discussion and conclusion: These results show that the response to antidepressive treatment depends on the diverse dietary regimens, especially low-caloric diet. We suggest that the background of this is augmentation of anidepressant and antineuronflammatory properties of some antidepressants by CR. Manipulation of dietary regimens is attractive and new strategy for the management of pharmacoresistant depression.
Telemedicine in Assistance to Healthcare in the COVID-19 Pandemic
Authors: Kilova K. , Uzunova S. 
Published: November 2020

Abstract
Global pandemics pose unprecedented challenges to healthcare. In the current situation, telemedicine appears to be a sustainable and effective solution in the implementation of precautions, prevention and treatment in order to discontinue the spreading of the coronavirus infection (COVID-19).
The aim of this paper was to research and analyze the role of telemedicine in assistance to healthcare in the COVID-19 pandemic.

Methods: The PubMed Database, Google Scholar, SpringerLink, ScienceDirect (Elsevier) and sites of public authorities have been accessed and reviewed.

Results: Advantages, restrictions, policy and application of telemedicine in the conditions of COVID-19 pandemic have been studied and analyzed.

Conclusion: Healthcare systems are put under an extreme test during global pandemics. Telemedicine is crucial during the COVID-19 pandemic because it guarantees that patients have access to medical care.
Comparison of yield, composition and quality of milk of Polish Holstein-Friesian cows in conventional and automatic milking systems
Authors: Kolenda Magdalena , Piwczyński Dariusz , Brzozowski Marcin , Sitkowska Beata , Wójcik Piotr 
Published: November 2020

Abstract
The aim of the present study was to evaluate the changes in selected production and functional traits of Polish Holstein-Friesian cows after switching from a conventional (CMS) to an automatic milking system (AMS). The study consisted of 3398 Polish Holstein- Friesian dairy cows, from 16 herds in which CMS was changed to AMS. Cows were in their 1st (L1) or 2nd lactation (L2). The data consisted of milk yield [MY, kg], fat content [FC, %], protein content [PC, %], dry matter [DM, %], lactose content [LC, %], urea content [MU, mg/l], somatic cell count [SCC, thous./ml] and score [SCS, log]. The milking system had a significant impact on milk yield, fat, lactose, dry matter and urea contents. Regardless of lactation number, milk derived from CMS was characterised by higher values for FC, PC, DM SCC and SCS, while milk from AMS had higher MY, LC and MU. Multifactor analysis of variance also confirmed significant effect of herd, season, herd × milking system interaction on SCS in milk of cows in L1. In the studied herds change from CMS to AMS was evaluated separately for cows in L1 and L2. The transitioning from CMS to AMS resulted in the decrease of fat content in 6 L1 and 7 L2 herds, dry matter in 8 L1 and 5 L2 herds. SCS in milk also decreased in 4 L1 and 5 L2 herds. The change caused the increase of MY in 11 L1 and 9 L2 herds, lactose content in 6 L1 and 4 L2 herds and urea content in 9 L1 and 10 L2 herds. AMS may positively affect milk yield and health status, however, the change of milking system should be also accompanied by the change in herd management.
Sex Dependent Action of Aroclor 1254 on Basal and sGnRHa-Stimulated Secretion of LH from the Pituitary Cells of Common Carp, Cyprinus carpio L.
Authors: Socha Magdalena , Sokołowska-Mikołajczyk Mirosława , Chyb Jarosław , Drąg-Kozak Ewa , Łuszczek-Trojnar Ewa 
Published: November 2020

Abstract
Polychlorinated biphenyls (PCBs) affect the hypothalamic-pituitary-gonadal axis in many vertebrates, changing the hormonal regulation of reproduction. To identify one of the possible sites of action of PCBs on gonadotropin release in common carp, the direct effects of Aroclor 1254 on luteinizing hormone (LH) secretion from dispersed pituitary cells were investigated. Pituitary cells were obtained from sexually mature male and female common carp (Cyprinus carpio L.) at the time of natural spawning. The cells were incubated with different concentrations of Aroclor 1254 (5, 10, 50 and 100 ng mL–1 medium) and/or salmon gonadotropin-releasing hormone analogue (sGnRHa) at a concentration of 10−8 M. LH levels were measured in the cultured medium by the ELISA method after 10 hours of cell incubation. Incubation of male pituitary cells in the presence of tested concentrations of Aroclor did not change the basal LH secretion to the media. In the female pituitary cell incubations Aroclor (5, 10 and 100 ng mL–1 medium) caused a significant increase in LH concentrations in comparison to control incubations. In the case of sGnRHastimulated LH secretion in incubations of cells of both sexes, all the concentrations of Aroclor significantly stimulated LH release and potentiated stimulatory effects of sGnRH analogue. These results indicate that endocrine disrupters, such as Aroclor 1254, may affect reproduction in fish, acting also directly on gonadotrophs at the level of the pituitary gland, changing LH secretion.
Effects of feeding urea-treated triticale and oat grain mixtures on ruminal fermentation, microbial population, and milk production performance of midlactation dairy cows
Authors: Libera Kacper , Szumacher-Strabel Malgorzata , Vazirigohar Mina , Zieliński Wiktor , Lukow Rafal , Wysocka Klaudia , Kołodziejski Pawel , Lechniak Dorota , Varadyova Zora , Patra Amlan Kumar , Cieslak Adam 
Published: November 2020

Abstract
The starch content of triticale and oat grains provides much of their readily available energy. Synchronizing energy and nitrogen in the rumen is important in optimizing profitability; for this reason, ammonia processing of these grains was evaluated for its potential to modify ruminal fermentation and to improve milk production performance. A mixture of ground triticale and oats (CONG, at a ratio of 60:40 on a dry matter basis) was treated with urea (5 kg/1000 kg) and urease additive (20 kg/1000 kg) containing 200 g/kg of moisture, for 2 wk (UREG). The urea treatment enhanced the pH and CP content of grains by 34% and 52%, respectively. In a batch culture study, CONG or UREG as the only substrate was incubated in a buffered ruminal fluid. Compared to CONG, UREG increased pH, total VFA concentration, total gas, and disappearance of DM, while reducing CH4 production, whereas NH3 concentration increased and entodiniomorph counts tended to increase. In the in vivo study, cows were randomly allocated to two dietary groups (n = 24) and were offered TMR based on maize and grass silage, containing either 155 g/kg of CONG and 80 g/ kg of soybean meal (CONT) or 155 g/kg of UREG and 59 g/kg of soybean meal (URET) for 31 d. Ruminal fluid was collected (n = 10) using rumenocentesis. The relative abundances of Streptococcus bovis decreased, but Megasphaera elsdenii, methanogens, and ammonia-producing bacteria increased by URET. Entodiniomorph and holotrich counts were decreased by URET. Feeding with URET increased ruminal pH and concentrations of total VFA, acetate, branched-chain VFA, and NH3. Feeding with URET also increased milk yield. These results demonstrate that replacing untreated triticale and oat grains with urea-treated grains can beneficially modulate ruminal microbiota and fermentation, consequently improving production performance and profitability.
Some population parameters of Bengal yellowfin seabream, Acanthopagrus longispinnis (Val.), from Hatiya Island, Bay of Bengal
Authors: Siddique Mohammad Abdul Momin , Hossain Md. Soliman , Hossain Md. Sabbir , Hasan Zahid , Das Jewel , Mustafa Golam 
Published: November 2020

Abstract
Size frequency, length-weight relationships (LWRs), length-length relationships (LLRs), and relative condition factor (Kn) was studied in an estuarine fish the Bengal yellowfin seabream, Acanthopagrus longispinnis (Val.), from Hatiya Island in the Meghna River estuary. Specimens were caught with fixed purse nets of two mesh sizes (0.2 to 0.5 inch and 2.0 to 2.5 inch) from January to March 2020. The total body length of A. longispinnis ranged between 5.8 and 9.3 cm throughout the sampling period. The length-weight relationships for A. longispinnis was highly significant (p < .001), and the adjusted r
2 value was 0.921. The calculated growth coefficient (b) for A. longispinnis was 3.163, which indicated a hyperallometric growth pattern. The length-length equation TL = 1.1384 SL + 0.4899 for unsexed A. longispinnis was highly significant (p = 0.001, r2 = 0.951). There were no significant variations in relative condition factors among the specimens of different length classes (5.5–9.5 cm). No information regarding length-weight or length-length relationships for A. longispinnis was previously reported in FishBase. Our estimated LWR and LLR parameters for A. longispinnis can be useful for management and conservation purposes of this estuarine species.