bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the potential of a reduced dose of dimethyl disulfide plus metham sodium on soilborne pests and cucumber growth
Authors: Mao Liangang , Jiang Hongyun , Zhang Lan , Zhang Yanning , Sial Muhammad Umair , Yu Haitao , Cao Aocheng 
Published: December 2019

AbstractMethyl bromide (MB), a dominant ozone-depleting substance, is scheduled to be completely phased out for soil fumigation by December 30th 2018, in China. The combined effects of dimethyl disulfide (DMDS) plus metham sodium (MNa) were assessed in controlling soilborne pests for soil fumigation. A study was designed in laboratory for the evaluation of the efficacy of DMDS + MNa to control major soilborne pests. At the same time, two trials were conducted in cucumber field located in Tongzhou (in 2012) and Shunyi (in 2013), respectively, in order to assess the potential of DMDS + MNa in controlling soilborne pests. Laboratory studies disclosed positive synergistic effects of almost all four used combinations on Meloidogyne spp., Fusarium spp., Phytophthora spp., Abutilon theophrasti and Digitaria sanguinalis. Field trials found that DMDS + MNa (30 + 21 g a. i. m−2), both at a 50% reduced dose, effectively suppressed Meloidogyne spp. with a low root galling index (2.1% and 11.7%), significantly reduced the levels of Phytophthora and Fusarium spp. with a low root disease index (7.5% and 15.8%), gave very high cucumber yields (6.75 kg m−2 and 10.03 kg m−2), and increased income for cucumber growers with the highest economic benefits (20.91 ¥ m−2 and 23.58 ¥ m−2). The combination treatment provided similar results as MB standard dose treatment (40 g a. i. m−2) or DMDS standard dose treatment (60 g a. i. m−2) in pest control and yield, but was more effective than MNa standard dose treatment (42 g a. i. m−2). Usage of all chemical treatments gave better significant results than the untreated group of control. Considering the economic benefits, the DMDS plus MNa combination (30 + 21 g a. i. m−2) could be used for soil fumigation in cucumber production in China.
Genetic interactions between INPP4B and RAD50 is prognostic of breast cancer survival
Authors: Chen Xiao , Theobard Rutaganda , Zhang Jianying , Dai Xiaofeng 
Published: December 2019

Abstract
RAD50 is commonly depleted in basal-like breast cancer with concomitant absence of INPP4B and several tumor suppressors such as BRCA1 and TP53. Our previous study revealed that INPP4B and RAD50 interact and such an interaction is associated with breast cancer survival at the transcriptional, translational and genomic levels. In the present study, we explored single nucleotide polymorphisms (SNPs) of these two genes that have synergistic effects on breast cancer survival to decipher mechanisms driving their interactions at the genetic level. The Cox’s proportional hazards model was used to test whether SNPs of these two genes are interactively associated with breast cancer survival, following expression quantitative trait loci (eQTL) analysis and functional investigations. Our study revealed two disease-associating blocks, each encompassing five and two non-linkage disequilibrium linked SNPs of INPP4B and RAD50, respectively. Concomitant presence of any rare homozygote from each disease-associating block is synergistically prognostic of poor breast cancer survival. Such synergy is mediated via bypassing pathways controlling cell proliferation and DNA damage repair, which are represented by INPP4B and RAD50. Our study provided genetic evidence of interactions between INPP4B and RAD50, and deepened our understandings on the orchestrated genetic machinery governing tumor progression.
Adulteration detection in petroleum products using directly loaded coupled‐line‐based metamaterial‐inspired submersible microwave sensor
Authors: Tiwari Nilesh Kumar , Singh Surya Prakash , Akhtar M Jaleel 
Published: December 2019

A modified design topology of planar submersible sensor, to realize the improved sensitivity, using the split ring resonator (SRR) loaded coupled microstrip line is presented. The designed sensor can easily be immersed in the liquid sample under test. The maximum numerical sensitivity of the designed sensor (11.58%) at the design frequency of 6.12 GHz is quite higher than the sensitivity of earlier reported submersible sensor (4.01%). The measured unloaded resonant frequency of the fabricated sensor shows a close match with the corresponding simulated data. The fabricated sensor prototype can distinguish between the test samples having nearly similar dielectric properties due to its improved sensitivity. Two significant aspects of petrochemical industries in the Indian continent, i.e. contamination/blending of petrol with kerosene/ethanol are mainly considered here. As the discrimination between petrol and kerosene using the commonly available microwave sensors is especially quite challenging due to the very similar dielectric behaviour of these two chemicals. The developed prototype can typically measure the minimum 2% level of kerosene adulteration in petrol corresponding to 7.5 MHz shift in the measured resonant frequency. The uncertainty in the measured frequency shift of the liquid samples using the proposed sensor is found to be ∼1 MHz.
Efficient time‐domain numerical modelling of crosstalk between coaxial cables incorporating frequency‐dependent parameters
Authors: Teo Yu Xian , Thomas David W.P. , Christopoulos Christos 
Published: December 2019

This study presents an analysis of time‐domain crosstalk between two parallel coaxial cables from 10 MHz − 1 GHz. Although such coupling has been extensively studied in the frequency domain, it is advantageous to evaluate the coupling in the time‐domain for the analysis of signal integrity‐related issues. The near‐end crosstalk is modelled using one dimensional transmission line modelling (TLM) approach, which is validated against practical measurements and commercial simulation software. A prony approximation method and equivalent circuit approach were used to account for frequency‐dependent parameters such as surface transfer impedance and skin effect in the TLM simulations.
GRIN2A-Related Severe Epileptic Encephalopathy Treated with Memantine: An Example of Precision Medicine
Authors: Mir Ali , Qahtani Mohammed , Bashir Shahid 
Published: December 2019

AbstractEpileptic spasm (ES) is one of the seizure types which is difficult to treat. Next-generation sequencing has facilitated rapid gene discovery that is linked to ES and GRIN2A being one of them. Genotype-driven precision medicine is on the horizon and is a targeted treatment approach toward the precise molecular cause of the disease. GRIN2A gene encodes for a subunit of N-methyl-D-aspartate (NMDA) receptor and it has been suggested from in vitro studies and few case reports that memantine, a NMDA receptor antagonist, was shown to reduce seizures in patients with GRIN2A mutations. Here, we describe a patient with a novel GRIN2A mutation and severe drug-resistant ES who became seizure free with memantine.
DeepRiPP integrates multiomics data to automate discovery of novel ribosomally synthesized natural products
Authors: Merwin Nishanth J. , Mousa Walaa K. , Dejong Chris A. , Skinnider Michael A. , Cannon Michael J. , Li Haoxin , Dial Keshav , Gunabalasingam Mathusan , Johnston Chad , Magarvey Nathan A. 
Published: December 2019

Significance
Natural products form the basis for most drugs in clinical use. Advances in genome sequencing and bioinformatic tools have revealed thousands of biosynthetic gene clusters encoding these products. However, linking natural products identified by genome mining to their corresponding products in untargeted metabolomics data remains a key challenge. Here we present a platform, DeepRiPP, which integrates genomic and metabolomic data to automate the discovery of new ribosomally synthesized posttranslationally modified peptides (RiPPs), a subclass of natural products with diverse chemistry and activities. We apply DeepRiPP to discover 3 novel RiPPs.
Teaching varies with task complexity in wild chimpanzees
Authors: Musgrave Stephanie , Lonsdorf Elizabeth , Morgan David , Prestipino Madison , Bernstein-Kurtycz Laura , Mundry Roger , Sanz Crickette 
Published: December 2019

SignificanceUnderstanding social influences on how apes acquire tool behaviors can help us model the evolution of culture and technology in humans. Humans scaffold novice tool skills with diverse strategies, including the transfer of tools between individuals. Chimpanzees transfer tools, and this behavior meets criteria for teaching. However, it is unclear how task complexity relates to this form of helping. Here, we find differences between 2 wild chimpanzee populations in rate, probability, and types of tool transfer during termite gathering. Chimpanzees showed greater helping in the population where termite gathering is a more complex tool task. In wild chimpanzees, as in humans, regular and active provisioning of learning opportunities may be essential to the cultural transmission of complex skills.
Long-term effects of cultural filtering on megafauna species distributions across China
Authors: Teng Shuqing N. , Xu Chi , Teng Licheng , Svenning Jens-Christian 
Published: December 2019

SignificanceHuman activities have played an important role in driving biodiversity loss throughout history, but the nature of these dynamics remains unclear. Importantly, the role of cultural evolution is mostly ignored, despite strong societal changes over time worldwide. Here, we show that megafauna range contractions across China in the last 2 millennia have been dominated by the spread of farming and agricultural intensification, often associated with expansion of the Han culture, with little or no direct importance of climate change. Our findings demonstrate that cultural evolution is important for shaping the assembly of contemporary communities from historical regional species pools and has long overshadowed climate change in driving even broadscale biodiversity patterns.
Abortive herpes simplex virus infection of nonneuronal cells results in quiescent viral genomes that can reactivate
Authors: Cohen Efrat M. , Avital Nir , Shamay Meir , Kobiler Oren 
Published: December 2019

Significance
Abortive viral infections are defined as cells that have been infected with a virus but did not produce any progeny virus as a result of the infection. Recent single-cell studies have shown that abortive infection is observed frequently even during infection of susceptible and permissive cell types. Here, we recovered populations of susceptible and permissive cells that survived infection with herpes simplex virus at high multiplicity of infection. We found that these abortive cells maintain viral genomes in a quiescent state at least for 5 wk. These viral genomes can reactivate to produce new progeny viruses. These findings suggest that abortive HSV-1 infection leads to spontaneous latency-like infection in nonneuronal cells, challenging the current paradigm of herpesviruses latency.
Lessons from equilibrium statistical physics regarding the assembly of protein complexes
Authors: Sartori Pablo , Leibler Stanislas 
Published: December 2019

Significance
In order to carry out their functions, most proteins assemble into multicomponent complexes. In the process of assembly, complexes need to discriminate their specific components from a mixture of hundreds of different proteins present in the cell. To assess some of the implications of this requirement, we develop a minimal model of self-assembly based on equilibrium statistical physics. We argue that the need to assemble reliably imposes fundamental constraints on the characteristics of complexes, which we support with analysis of available structural and compositional data. Our work constitutes only a step toward future theory of protein complex assembly, which will have to incorporate also nonequilibrium and kinetic aspects of this fundamental and rich, yet theoretically neglected, problem.
Trans-endocytosis of intact IL-15Rα–IL-15 complex from presenting cells into NK cells favors signaling for proliferation
Authors: Anton Olga M. , Peterson Mary E. , Hollander Michael J. , Dorward David W. , Arora Gunjan , Traba Javier , Rajagopalan Sumati , Snapp Erik L. , Garcia K. Christopher , Waldmann Thomas A. , Long Eric O. 
Published: December 2019

SignificanceInterleukin 15 (IL-15) is essential for natural killer (NK) cell survival and proliferation. The IL-15 receptor consists of 3 subunits: the α chain and the β and common γ (γc) chains, which are shared with the IL-2 receptor. NK cells express the β-γcchains and are activated intransby cells presenting IL-15 bound to IL-15Rα, such as dendritic cells. We show here that the release of soluble IL-15Rα–IL-15 complex from presenting cells contributes to efficient signaling for NK cell survival, whereas uptake of the entire membrane-associated-IL-15Rα–IL-15 complex from presenting cells into NK cells contributes to proliferation. Thus, outcomes are dictated not only by signal strength, but also by location where IL-15trans-presentation occurs in NK cells.
A low climate threshold for south Greenland Ice Sheet demise during the Late Pleistocene
Authors: Irvalı Nil , Galaasen Eirik V. , Ninnemann Ulysses S. , Rosenthal Yair , Born Andreas , Kleiven Helga (Kikki) F. 
Published: December 2019

Significance
Understanding how warmer climates affected Greenland in the past helps in determining how future warming will impact it. The Greenland Ice Sheet (GIS) has retreated during recent interglacials, suggesting a critical survival threshold within a few degrees of modern temperatures. Defining this temperature threshold requires records of the past climates responsible for GIS demise. Using microfossil temperature reconstructions, we show that the current interglacial is unusually moderate and that all 4 previous interglacials were warmer than present near Greenland. Both magnitude and duration of past warmth were important influences on the ice sheet. Notably, the critical temperature threshold for past GIS decay will likely be surpassed this century. The duration for which this threshold is exceeded will determine Greenland’s fate.
Quantitative microscopy reveals dynamics and fate of clustered IRE1α
Authors: Belyy Vladislav , Tran Ngoc-Han , Walter Peter 
Published: December 2019

Significance
The endoplasmic reticulum (ER) is the site for folding and maturation of secreted and membrane proteins. When the ER protein-folding machinery is overwhelmed, misfolded proteins trigger ER stress, which is frequently linked to human diseases, including cancer and neurodegeneration. Inositol-requiring enzyme 1 (IRE1) is an ER membrane-resident sensor that assembles into large clusters of previously unknown organization upon its activation by unfolded peptides. We demonstrate that IRE1 clusters are topologically complex dynamic structures that remain contiguous with the ER membrane throughout their lifetime. The majority of clustered IRE1 molecules are diffusionally trapped inside the clusters until IRE1 signaling attenuates, at which point they are released back into the ER through a pathway that is functionally distinct from cluster assembly.
Complexity-based approach for El Niño magnitude forecasting before the spring predictability barrier
Authors: Meng Jun , Fan Jingfang , Ludescher Josef , Agarwal Ankit , Chen Xiaosong , Bunde Armin , Kurths Jürgen , Schellnhuber Hans Joachim 
Published: December 2019

Significance
Although El Niño events characterized by anomalous episodic warmings of the eastern equatorial Pacific can trigger disasters in various parts of the globe, reliable forecasts of their magnitude are still limited to about 6 mo ahead. A significant extension of this prewarning time would be instrumental for mitigating some of the worst damages. Here we introduce an approach relying on information entropy, which achieves some doubling of the prewarning time. The approach is based on our finding that the entropy in one calendar year exhibits a strong correlation with the magnitude of an El Niño that starts in the following year and thus allows us to forecast the onset and the magnitude of an El Niño event 1 y in advance.
Multiscale porous elastomer substrates for multifunctional on-skin electronics with passive-cooling capabilities
Authors: Xu Yadong , Sun Bohan , Ling Yun , Fei Qihui , Chen Zanyu , Li Xiaopeng , Guo Peijun , Jeon Nari , Goswami Shivam , Liao Yixuan , Ding Shinghua , Yu Qingsong , Lin Jian , Huang Guoliang , Yan Zheng 
Published: December 2019

SignificancePoint-of-care thermal management (e.g., joule heating, passive cooling) shows promising applications in body temperature regulations, which can improve human comfort and reduce energy consumption. On-skin electronics with joule-heating elements have been reported. However, the research of making on-skin electronics with passive-cooling functionalities is still rare. By using multiscale porous polystyrene-block-poly(ethylene-ran-butylene)-block-polystyrene as supporting substrates, we have developed multifunctional on-skin electronics with outstanding passive-cooling capabilities, delivering around 6 °C cooling effects under a solar intensity of 840 W⋅m−2. Other desired properties, rooted in porous SEBS substrates, include high breathability and outstanding waterproofing. In addition, a variety of bioelectronic devices are made on porous SEBS substrates via spray printing of silver nanowires (Ag NWs). The enabled devices demonstrate high performance and are recyclable.
Synthesis of novel microencapsulated phase change material with SnO2/CNTs shell for solar energy storage and photo-thermal conversion
Authors: Ma Xiaochun , Liu Han , Chen Chen , Liu Yanjun , Zhang Lin , Xu Bin , Xiao Fan 
Published: December 2019

Abstract
In this study, In-situ precipitation reaction was used to prepare paraffin@SnO2/CNTs composite phase change materials. The paraffin@SnO2/CNTs composites material were prepared by using paraffin as a phase change core material, and tin dioxide and carbon nanotubes as composite shell materials. The microstructure, chemical composition and crystal phase structure of the composites were analyzed by Scanning electron microscope (SEM), Fourier infrared spectrum (FT-IR) and X-ray diffraction (XRD). The thermal performance and thermal stability of phase change materials were determined by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). The microcapsule has a core–shell structure with a diameter of 2–5 μm. The encapsulation efficiency of the paraffin@SnO2/CNTs composite was calculated to be 42.94%. The slurry is formed by dispersing microcapsules in water, which not only greatly improves the specific heat capacity, thermal conductivity, visible light absorption, but also makes the effective receiving efficiency reach 91.79% at 40 °C, indicating that it is a promising heat transfer working slurry in the field of Direct Absorption Solar Collectors (DASC) system.
Correcting the effect of the detection angular on laser-induced chlorophyll fluorescence
Authors: Yang Jian , Du Lin , Gong Wei , Shi Shuo , Sun Jia , Chen Biwu 
Published: December 2019

Abstract
Chlorophyll fluorescence has been widely used to monitor vegetation growth status and quantitative remote sensing monitoring of vegetation biochemical content. Therefore, it is significant to accurately measure the fluorescence information. In this study, the variation in fluorescence intensity of vivo vegetation leaf with the change in detection angle on the basis of laser-induced fluorescence technology was discussed. Experimental results demonstrated that the relationship between the emission fluorescence intensity and detection angles could be explained by the cosine expression. Then, two-step fluorescence intensity correction method was proposed. Firstly, the fluorescence intensity was corrected based on the changing of cosine expression. Secondly, the fluorescence ratio calculated based on the corrected fluorescence intensity. Results demonstrated that the effect of detection angles on fluorescence signals can be efficiently eliminated compared to the traditional spectral ratio method. Findings of this study may be valuable in promoting the applications of laser-induced fluorescence in remote sensing to achieve accurate chlorophyll fluorescence information for quantitative monitoring of plant nutrient stress.
An acoustic Lippmann-Schwinger inversion method: applications and comparison with the linear sampling method
Authors: Prunty Aaron C , Snieder Roel K 
Published: December 2019

Abstract
We introduce an imaging method based on solving the Lippmann-Schwinger equation of acoustic scattering theory. We compare and contrast the proposed Lippmann-Schwinger inversion with the well-established linear sampling method using numerical examples. We demonstrate that the two imaging methods are physically grounded in different but related wave propagation problems: Lippmann-Schwinger inversion seeks to reconstruct the space and time dependence of a scatterer based on the observed scattered field in a performed physical experiment, whereas the linear sampling method seeks to focus wave fields in a simulated virtual experiment by estimating the space and time dependence of an inverse source function that cancels the effects of the scatterer at a specified focusing point. In both cases, the medium in which the waves propagate is the same; however, neither method requires prior knowledge or assumptions on the physical properties of the unknown scatterer—only knowledge of the background medium is needed. We demonstrate that the linear sampling method is preferable to Lippmann-Schwinger inversion for target-oriented imaging applications, as Lippmann-Schwinger inversion gives nonphysical results when the chosen imaging domain does not contain the scatterer.
Environmental Issues and Social Work Education
Authors: Naranjo Nélida Ramírez 
Published: December 2019

AbstractEnvironmental issues have been well-documented in recent years, paying particular attention to the anthropogenic climate change impact. To date, research addressing the relationship between environmental issues, environmental justice and sustainability within social work education has been scarce. The importance of these topics in education, especially in social work programmes must be well understood and research being generated on these subjects must increase. The primary goal of this article is to help increase the conversation and debates about environmental issues, environmental justice and sustainability within the social work academic community. Social work scholars must analyse and discuss opportunities and difficulties that are presented by the necessity to make the subjects mentioned, key concepts of the core curriculum and base for social work education. The secondary goal is to describe practical ways that environmental issues, environmental justice and sustainability content can be integrated into social work education to better equip professionals with the tools to assist in the continuously growing global environmental issues.