bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of Survival Outcomes in Non-Metastatic Renal Cell Carcinoma in Latin America and Spain: A Multicentric Analysis
Authors: Zequi Stênio de Cássio , Mourão Thiago Camelo , de Oliveira Max Moura , Curado Maria Paula , Gueglio Guilhermo , da Costa Walter Henriques , Zuñiga Alvaro , Bengió Rubén , Scorticati Carlos , Rodriguez Francisco , Autran Ana Maria , Martínez Pablo , Ameri Carlos , Mingote Pablo , Secin Fernando Pablo , Decia Ricardo , da Cunha Isabela Werneck , Guimarães Gustavo Cardoso , Glina Sidney , Palou Joan , Abreu Diego 
Published: December 2019

Background: Renal cell carcinoma (RCC) is a lethal neoplasia. Data from Latin America are scarce, and the distinct ethnic origins of this population could affect predictive or prognostic factors. Objective: We aim to describe a large cohort of non-metastatic renal cell carcinoma, identifying the demographic, clinical, and pathological prognostic factors for survival. Methods: We used a multi-institutional retrospective cohort involving 5,670 patients who underwent radical or partial nephrectomy across seven Latin American countries and Spain from 1980 to 2016. The variables were compared, and Kaplan–Meier curves were used to estimate the overall survival (OS) and cancer-specific survival (CSS). Results: The clear cell subtype represented 66.7% of RCC, followed by chromophobe (13.7%), papillary (5.2%), and others (14.4%). Furthermore, 72.3% of renal masses were <7.0 cm. The 5-year OS and 10-year OS rates were 86.1% and 69.5%, respectively. The 5-year and 10-year CSS rates were 89.9% and 81.8%, respectively. The demographic and clinical predicting factors for OS in the multivariate analysis were age (HR: 2.978), anemia (HR: 1.44), presence of symptoms at presentation (HR: 1.26), Karnofsky score ≤80 (HR: 2.12), and ASA score ≥ 3 (HR: 1.49). The pathological factors were nodal metastasis (HR: 2.14), peri-renal fat invasion (HR: 2.12), inferior vena cava invasion (HR: 1.61), histologic tumoral necrosis (HR: 1.69), and tumor size >7 cm (HR: 1.64). Conclusions: Our findings agreed with those reported for some developed countries. We emphasize that ASA and peri-renal fat invasion as prognostic factors deserve further study. Information regarding microvascular invasion should be regularly incorporated in pathological reports.
Alat Pengurai Sabut Kelapa dengan Blade Portable Untuk Menghasilkan Cocofiber dan Cocopeat
Authors: Sepriyanto Sepriyanto 
Published: December 2019

Coconut as one of the leading plantation products in Jambi province, currently only rely on copra and coconut shell charcoal as the resulting product. Coconut removal as a by-product of coconut has not been utilized optimally. Coconut husk which is processed with precise and appropriate can produce high value product. This research aims to design, make and test the tool to decompose the coconut scale of household scale. Coconut coir decomposers are made with 1000x700x 1080mm tool dimensions, the driver uses 6.5 HP gasoline engine and an average engine capacity of 10 kg / hour. Knife cut (blade) on this tool can be removed (portable) so it can be tailored to the needs. The test was conducted to determine the effect of blade amount and time to the percentage of cocofiber and cocopeat produced. Number of blades varied ie 5 blades and 10 blades. Decomposition time varied from 1 minute, 2 minutes, 3 minutes, 4 minutes and 5 minutes, with a 650 rpm engine speed. The results of this study recommend to use 10 blades with a decomposition time for 5 minutes. The results obtained from the recommendation are cocofiber that decomposes as much as 32%, which does not decompose as much as 10% and cocopeat produced as much as 58%.Keywords: blade, portable, cocofiber, cocopeat.
Informe de la Secretaría General en relación con la solicitud de que se reconsidere el acuerdo de la Mesa de la Comisión Constitucional adoptado en el transcurso del debate de la propuesta de reforma del Estatuto de Autonomía de la Comunidad Valenciana:
Authors: Congreso de los Diputados Secretaría General 
Published: December 2019

nforme de la Secretaría General en relación con la solicitud de reconsideración del acuerdo de la Mesa de la Comisión Constitucional, adoptado en el debate sobre la propuesta de reforma del Estatuto de Autonomía de la Comunidad Valenciana respecto a la interpretación del artículo 114.3 del Reglamento.
Comparativa comentada del Tratado de Lisboa.
Authors: Gil-Robles Casanueva Loreto 
Published: December 2019

SUMARIO: Parte I. Tratado de la Unión Europea. Texto consolidado. Parte II. El Tratado de Funcionamiento de la UnIón Europea. Texto consolidado.
Comentado por Don José Mª Gil-Robles Gil-Delgado.
ULTRASOUND EXAMINATION OF BOWEL WALL THICKNESS IN PATIENTS WITH ACUTE INTESTINAL GRAFT-VERSUS-HOST DISEASE
Authors: Drokov M. Yu. , Dubnyak D. S. , Yatsyk G. A. , Kireeva A. A. , Pyrikova O. V. , Kuzmina L. A. , Popova N. N. , Vasilyeva V. A. , Maslikova U. V. , Parovichnikova E. N. 
Published: December 2019

Introduction. Haematopoietic stem cell transplantation is the treatment of choice in many patients with malignant diseases of the blood system. In such patients, acute graft-versus-host disease (GvHD) associated with intestinal damage constitutes one of the most serious complications. However, the volume of stool per day, which is currently used as the main diagnostic criterion for such conditions, does not always permit a timely diagnosis.Aim. To study the possibility of using intestine ultrasound examination for the diagnosis of acute intestinal GvHD.Materials and methods. The study included 50 patients having undergone transplantation of allogeneic haematopoietic stem cells, 40 of whom showed clinical signs of intestinal GvHD (diarrhoea> 500 ml/day). The control group included 10 patients who had undergone transplantation of allogeneic haematopoietic stem cells and exhibited no signs of gastrointestinal events. All patients underwent ultrasound measurement of intestinal wall thickness.Results. Patients were divided into three groups: those with acute GvHD, those with diarrhoea of viral or infectious origin, those with diarrhoea caused by the toxic effects of chemotherapy drugs. It is shown that the walls of all intestinal sections were signifi cantly thicker in patients with acute GvHD as compared to the control group and patients with diarrhoea caused by other reasons.Conclusion. The thickening of the caecum wall (more than 3.25 mm) as detected using the ultrasound method can be used as a diagnostic sign of intestinal GvHD.Conflict of interest: the authors declare no conflict of interest.Financial disclosure: the study had no sponsorship.
INTERIM RESULTS OF EPIDEMIOLOGICAL STUDY OF IDIOPATHIC THROMBOCYTOPENIC PURPURA IN ADULTS IN THE RUSSIAN FEDERATION: INTERMEDIATE RESULTS
Authors: Melikyan A. L. , Egorova E. K. , Pustovaya E. I. , Kolosheinova T. I. , Volodicheva E. M. , Kaporskaya T. S. , Ilyasov R K. , Shelekhova T. V. , Fedorova N. A. , Zotova I. I. , Sycheva T. M. , Kontievsky I. N. , Shestopalova I. L. , Kurkina N. V. , Syrtseva E. B. , Tarasenko E. V. , Meresiy O. V. , Cherkashenko Z. V. , Chabaeva Yu. A. , Kulikov S. M. 
Published: December 2019

Introduction. Primary immune thrombocytopenia (idiopathic thrombocytopenic purpura, ITP) is a rare autoimmune disorder, whose main clinical manifestation consists in the hemorrhagic syndrome of varying severity. The therapy for ITP is aimed at eliminating hemorrhagic manifestations and maintaining patients’ quality of life. There is no information on the incidence of ITP, as well as on the clinical course and response to the treatment of ITP patients, in the Russian Federation.Aim. To estimate the epidemiological and clinical characteristics of ITP in the adult population of the Russian Federation.Materials and methods. We studied clinical and laboratory data derived from electronic medical records of ITP patients having participated in a multi-centre, prospective, observational, cohort study “Epidemiological and Clinical Characteristics of ITP in Adults in Russia” carried out from 2014 to 2017. The data was processed employing methods of descriptive statistics, as well as frequency analysis, event analysis and analysis of variance. The calculations were performed using the SAS V9.4 statistical package.Results. The incidence of ITP in the adult population in three selected regions of the Russian Federation averaged 2.09 per 100 thousand people per year. The highest incidence rate in gender-age groups was observed in women under 40 years of age mounting to 2.7 per 100 thousand. A gradual increase in the incidence rate from 1.09 to 2.5 per 100 thousand was noted in the men over 60 years of age. A significant correlation was found between the risk of developing the hemorrhagic syndrome, its severity and the platelet count at the onset of the disease (p<0.0001). In 92.2 % of cases, glucocorticosteroid hormones were prescribed as the first line of therapy. The analysis of methods used as the second line of therapy revealed that, although splenectomy is performed relatively frequently, its likelihood has decreased from 26 to 17 % over the past three years. In addition, the proportion of patients being treated with thrombopoietin receptor agonists has increased from 5.9 to 45.7 %.Conclusion: The incidence of ITP in three selected regions of the Russian Federation is comparable to that in other European countries.Conflict of interest: the authors declare no conflict of interest.
Природные материалы для сорбционной очистки хром- и кадмийсодержащих инфильтратов полигонов ТБО
Authors: Safonov A. , Andriushchenko N. , Popova N. , Boldyrev K. 
Published: December 2019

Проведен анализ сорбционных характеристик природных материалов (вермикулит, керамзит, перлит, цеолит Трейд ) при очистке кадмий- и хромсодержащих сточных вод с высокой нагрузкой по ХПК. Установлено, что цеолит обладает максимальными сорбционными характеристиками для Cd и Cr и наименьшим биологическим обрастанием. При использовании вермикулита и керамзита или смесей на их основе можно ожидать увеличения сорбционной емкости для Cd и Сr при микробном обрастании, неизбежно происходящем в условиях контакта с водами, загрязненными органическими соединениями и биогенами. При этом биообрастание может повысить иммобилизационную способность материалов для редоксзависимых металлов за счет ферментативных ресурсов бактериальных клеток, использующих их в качестве акцепторов электронов. Эффект микробного обрастания разнонаправленно изменял параметры материалов: для Cr в большинстве случаев уменьшение и для Cd значительное увеличение. При этом дополнительным эффектом иммобилизации Cr является его биологическое восстановление биопленками. Варьируя состав сорбционного материала, можно подбирать смеси, оптимально подходящие для очистки вод инфильтратов с полигонов твердых бытовых отходов с высокой нагрузкой по ХПК и биогенным элементам как при использовании in situ, так и в системах на поверхности.The analysis of the sorption characteristics of natural materials (vermiculite, expanded clay, perlite, Trade zeolite) during the purification of cadmium and chromium-containing leachate with a high COD load was carried out. It was determined that zeolite had the maximum sorption capacity for Cd and Cr and the lowest biological fouling. When using vermiculite and expanded clay or mixtures on their basis, one can expect an increase in the sorption capacity for Cd and Cr during microbial fouling that inevitably occurs during contacting with water polluted with organic compounds and nutrients. In this case biofouling can increase the immobilization properties of materials for redox-dependent metals due to the enzymatic resources of bacterial cells that use them as electron acceptors. The effect of microbial fouling changed the parameters of materials in different directions: for Cr, in most cases, downward, and for Cd, significantly upward. Moreover, chromium biological recovery by biofilms is an additional effect of immobilization. Varying the composition of the sorption material provides for selecting mixtures that are optimally suitable for the purification of leachates from solid waste landfills with high COD and nutrients load, both when used in situ and in surface systems.
Caracterización del perfil de pruebas tiroideas en un hospital universitario colombiano
Authors: Noreña Jairo Arturo , Alzate Leidy , Becerra Maria Gabriela , Builes-Barrera Carlos Alfonso 
Published: December 2019

Introducción: se carece de guías clínicas claras para la solicitud de pruebas tiroideas en pacientes
hospitalizados. Se evaluó el nivel de pertinencia y tipos de perfil solicitados en pacientes
hospitalizados en el Hospital Universitario de San Vicente Fundación.
Métodos: estudio retrospectivo en pacientes mayores de 14 años, no gestantes, hospitalizados
en el Hospital Universitario de San Vicente Fundación. Se evaluaron 351 registros en el sistema
de historia clínica, se definieron seis grupos de pertinencia, las categorías 1 a 4 se consideraron
como pertinente, y la 5 y 6 como solicitudes de pruebas no pertinentes. Se registraron variables
demográficas y clínicas. Las variables estadísticas cuantitativas fueron evaluadas con la prueba U
Mann-Whitney, las variables cualitativas con chi2 Pearson y Estadístico de Fisher.
Resultados: se obtuvieron valores normales en 67% de las TSH medidas, en 80% de las T4 y el
53% de las T3. La anormalidad más frecuente de la TSH fue elevación en 24%, para la T4 libre fue su
reducción en 11.5% y para la T3 elevación en 27%. Se encontró TSH ≤ 0.1 en 3.5% y ≥ 20 en 3.9%.
De los 60 pacientes con TSH elevada el 75% están entre 5 y 9.99 mUI/mL. La T4L ≤ de 0.7 ng/dL fue
11.5% y ≥ 1.48 en 8.6%. El 95% de las T4L medidas en la categoría no pertinente fueron normales.
Conclusiones: se debe mejorar la pertinencia de solicitud de pruebas tiroideas en hospitalización.
Se propone abordaje inicial solo con TSH
Caracterización de trasplantados renales con donantes de criterios expandidos
Authors: García-Padilla Paola Karina , Vargas-Brochero María José , Hurtado-Uriarte Maite , González-González Camilo Alberto , Rodríguez-Sánchez Martha Patricia , Patiño Juan Agustín , Contreras Villamizar Kateir Mariel 
Published: December 2019

Introducción: el trasplante renal es el tratamiento de elección para pacientes con enfermedad renal crónica, sin embargo, el número de donantes es insuficiente y las listas de espera crecen exponencialmente cada año. El trasplante con donante de criterios expandidos beneficia a un número importante de pacientes, mejorando su supervivencia al compararlos con los que permanecen en diálisis. El objetivo de este estudio es describir las características de pacientes trasplantados con donantes de criterios expandidos y su función renal al primer y tercer año del trasplante.
Métodos: se realizó un estudio descriptivo observacional. Se eligieron pacientes mayores de 18 años trasplantados con donante de criterios expandidos entre 2007 y 2015.
Resultados: de un total de 227 pacientes analizados, 18 fueron trasplantados con donante de criterios expandidos. Los receptores tenían 59.5 años (37-79), tiempo en lista de espera de 22.4 meses (2.6-77.8), tiempo en diálisis de 4.5 años (0.5-18.4). La edad del donante fue 61 años (50-73). La supervivencia del injerto al año fue 88.9% y a los tres años de 80%. El 11.1% de los pacientes presentaron rechazo celular agudo al año y el promedio de la tasa de filtración glomerular al primer y tercer año fue de 58.4 mL/min/1.73m2.
Conclusión: los pacientes trasplantados con donante de criterios expandidos tienen una buena función del injerto renal a tres años, con supervivencia del injerto y del paciente, similar a la reportada con donante con criterio estándar.
Métodos: se realizó un estudio descriptivo observacional. Se eligieron pacientes mayores de 18 años trasplantados con donante de criterios expandidos entre el 2007 y 2015.
Resultados: de un total de 227 pacientes analizados, 18 fueron trasplantados con donante de criterios expandidos. Los receptores tenían un promedio de edad de 59,3 años, tiempo en lista de espera de 29,9 meses, tiempo promedio en diálisis de 7 años. La edad promedio del donante fue 61 años. La supervivencia del injerto al año fue 88,9% y a los 3 años de 80%. El 11,1% de los pacientes presentaron rechazo celular agudo al año y el promedio de la tasa de filtración glomerular al primer y tercer año fue de 58,4 ml/min/1,73m2.
Conclusión: Los pacientes trasplantados con donante de criterios expandidos tienen una buena función del injerto renal a 3 años, con supervivencia del injerto y del paciente similar a la reportada con donante con criterio estándar
Síndrome de vasoconstricción cerebral reversible
Authors: Campbell-Silva Santiago , Gómez-Pinedo Roberto Alfonso , Ramírez-Blanco Luis Alfonso 
Published: December 2019

El síndrome de vasoconstricción reversible es un grupo de alteraciones clínico-radiológicas que se caracterizan por cefaleas intensas de inicio brusco y estrechamiento multifocal reversible de las arterias cerebrales. La mayoría de los pacientes no presentan déficit neurológico focal, aunque puede verse en un grupo reducido asociándose con edema cerebral, ataque cerebrovascular o convulsiones. Es considerado un proceso benigno, en pocos casos originan discapacidad y muerte en una minoría de pacientes.
El término de síndrome de vasoconstricción reversible se ha propuesto para unificar a una variedad de síndromes clínicos similares, pero de etiología diferentes y han originados diversos epónimos.
La aparente baja frecuencia del síndrome de vasoconstricción reversible y su forma de presentación hace que se convierta en un reto diagnóstico en los servicios de urgencias y puede pasar desapercibido si no se tiene una historia clínica adecuada.
Presentamos un caso probablemente relacionado al uso de isometepteno.
Pedro Guibovich Pérez. En defensa de Dios: estudios y documentos sobre la Inquisición en el Perú
Authors: Firbas Paul 
Published: December 2019

Desde la abolición del Tribunal de la Inquisición en el Perú, a principios del siglo XIX, el llamado Santo Oficio ocupa un lugar prominente en las narraciones y la imaginación sobre el mundo colonial. A mediados de 1997, las Ediciones del Congreso sacaron a luz el estudio de Fernando Ayllón, El Tribunal de la Inquisición: de la leyenda a la historia, con prólogo de Guillermo Lohmann Villena. Esta extensa monografía recorre la historia de esta institución desde sus antecedentes medievales, su instauración en la Península e Hispanoamérica, hasta su decadencia y desaparición.
Association of Serum Uric acid with Recent Ischaemic Stroke
Authors: Gyawali Suraj 
Published: December 2019

Introduction: To evaluate association of serum uric acid with ischemic stroke patients and assess its relationship with cerebrovascular risk factors.
Methods: This was a hospital based cross-sectional observational study conducted at TUTH between May 2016 to May 2017. A total 120 Patients eligible for the study criteria was enrolled for the study. Nonprobability convenience sampling was used for the sampling purpose. All patients ages 40 years or above 40 years with confirmed diagnosis of recent ischaemic stroke were included for the analysis.
Results: Mean ages of the enrolled subjects were 60.63 years ± 11.11 SD and eighty three (69.2%) population were male. Sixty one (50.8%) subjects were smoker and twenty seven (22.5%) were alcoholic. Prevalence of hyperuricemia was 17.5%. Serum uric acid level values were higher in male(69.1%) than female(30.9) population..Higher levels of serum uric acid level were found in both male population who smoked and were alcoholic in contrast serum uric acid levels were higher in both female population who were non smoker and did not consume alcohol in comparison to male. .Likewise, both diabetic and dyslipidemic male and female had higher serum uric acid level in comparison to who were non diabetic and did not consume alcohol. The mean score of serum uric acid level in male and female were significa different (P=0.029). Similalry, serum uric acid level was significantly different in smoker and no-smoker group (p=0.049), hypertensive and non hypertensive (p=0.027) and dyslipidemic and non dyslipidemic group (p=0.005)
Conclusions: Our study showed high prevalence of hyperuricemia in ischemic stroke patients and there was a potential link between serum uric acid and cerebrovascular risk factors, indicating possible role of uric acid as the risk factor of ischemic stroke.
Keywords: cerebrovascular risk factor; Uric acid level, recent ischaemic stroke.
Escrita e Leitura em Geometriquês
Authors: Velasco Jaime , Cunha Sueli 
Published: December 2019

O estudo da linguagem matemática pode ser comparado ao de uma língua estrangeira; isto é, deve-se conhecer suas regras gramaticais (em diversos níveis de aprendizagem como básico, intermediário e avançado) para melhor compreender um texto, ou uma expressão, escritos nesta linguagem. Além disso, por vezes é interessante observar os dialetos, caracterizando as diferenças regionais (no caso de uma língua natural), que podem ser comparadas às diferenças entre as diversas áreas da matemática. Este artigo trata de uma breve introdução ao dialeto Geometriquês, e aborda algumas das dificuldades em termos de nomenclatura, e de escrita e leitura de frases neste dialeto, bem como faz uma pequena comparação entre o Geometriquês e o Algebrês.
Ethno-Medicinal Survey of Plants Used in Fever and Biological Activity of Selected Medicinal Plants
Authors: Paudel Sunila , Raj Joshi Khem 
Published: December 2019

Fifty one plant species belonging to 35 families were documented for the traditional treatment of fever. The widely used species are Centellaasiatica (50%), Ocimumsantum (22.5%), Cissampelospareira (19.5%), Rubusellipticus (10%), and Allium hypsistum (14%). Leaves were used in majority of cases followed by roots in the form of decoction, juice, infusion with or without solvents such as water. Leave extract of R. ellipticus showed potent antioxidant activity towards 1,1-diphenyl-2-picryl hydrazyl (DPPH) free radical scavenging activity with IC50 value 2.98 µg/ml compared with standard Ascorbic acid (4.77 µg/ ml). The antibacterial activity of the leave of R. ellipticus showed comparable zone of inhibition with that of standard drugs at a concentration of 1 mg/ml.
Keywords: Fever, Antioxidant, Antimicrobial activity, Rubusellipticus, Centellaasiatica