bluuebunny/crossref_metadata_2025_split huggingface dataset:
Altered Diversity and Composition of Gut Microbiota in Wilson's disease
Authors: Cai Xiangsheng , Deng Lin , Ma Xiaogui , Guo Yusheng , Feng Zhiting , Liu Minqi , Guan Yubin , Huang Yanting , Deng Jianxin , Li Hongwei , Sang Hong , Liu Fang , Yang Xiaorong 
Published: February 2020

Abstract
Background: Wilson’s disease (WD) is a rare autosomal recessive inherited disorder of chronic copper toxicosis with high mortality and disability. Recent evidence suggests a correlation between dysbiosis in the gut microbiome and metabolic disease. Therefore, the impact of intestinal microbiota polymorphism in WD need to be explore for seeking some microbiota benefit for WD patients. Methods: In this study, the 16S rRNA sequencing was performed on fecal samples from 14 patients with WD and were compared to the results from 16 healthy individuals. The diversity and composition of the gut microbiome in the WD group were significantly lower than those in healthy individuals. Results: The WD group presented unique richness of Gemellaceae , Pseudomonadaceae and Spirochaetaceae at family level in WD group, which were hardly detected in healthy controls The WD group had a markedly lower abundance of Acidobacteria , Firmicutes and Verrucomicrobia , and a higher abundance of Bacteroidet es, Proteobacteria , Cyanobacteria and Fusobacteria than that in healthy individuals. The Firmicutes to Bacteroidetes ratio in the WD group was significantly lower than that of healthy control. The functional profile of the gut microbiome from WD patients showed a lower abundance of bacterial groups involved in the pathways of transcription factors and ABC-type transporters, compared to healthy individuals. The dysbiosis of gut microbiota may be influenced by the host metabolic disorders of WD such as signaling pathway of ABC-type transporters and multiple metabolic modules. Conclusions: This study provides a new understanding of the pathogenesis of WD and new possible therapeutic targets.
MMP-13 Enzyme and pH Responsive Theranostic Nanoplatform for Osteoarthritis
Authors: lan qiumei , Chen Haimen , Pang Yunfen , Xiong Feng , Shen Chong , Qin Zainen , Zheng Li , Zhao Jinmin 
Published: February 2020

Abstract
Stimulus-responsive therapy permits precise control of therapeutic effect only at lesion of interest, which determines it a promising method for diagnosis and imaging-guided precision therapy. The acid environment and overexpressed matrix metalloproteinases-13 (MMP-13) are typical markers in osteoarthritis (OA). However, stimulus-responsive therapeutic platform with high specificity for OA basing on the two markers has not been developed yet. We herein demonstrate a new stimuli-responsive theranostic strategy against OA based on a novel multifunctional nano-micelle which is rationally designed and yet readily synthesized. Such nanoplatform is incorporated with a motif specifically targeting on cartilage, a motif responsive to matrix metalloproteinases-13 to specifically report OA condition and biodynamics of nano-micelles, an anti-inflammatory drug (e.g., psoralidin (PSO)) from traditional Chinese medicine, and a biocompatible polymeric skeleton for sustainable drug release in response to the acidic OA condition. The high effectiveness of this targeted precision therapy is demonstrated comprehensively by both in vitro an in vivo evidences.
Evaluation of job security among operating room nurses of teaching hospitals, Kermanshah University of Medical Sciences
Authors: Safari Yahya , Foroutanfar Fatemeh 
Published: February 2020

Abstract
Background: This study assessed job security among operating room nurses of teaching hospitals, Kermanshah University of Medical Sciences in Kermanshah, Iran.Methods: The population of this descriptive-analytical study included all operating room nurses (n=217) of teaching hospitals affiliated to Kermanshah University of Medical Sciences in 2017, from whom 136 were chosen as study sample by simple random sampling and Kerjesi-Morgan table. Data were collected by Nissi’s job security questionnaire. The obtained data were analyzed by Pearson’schi-square and one-way ANOVA tests.Results: The findings showed the job security of the majority of nursing staff was average in low job displacement (66.9%), job satisfaction (68.5%), emotional work environment (65.5%), sense of peace (71%), organizational commitment (44.4%) and organizational defense (55.6%) domains. However, their job security was high in concentration on job (89.5%) and choosing an appropriate job (90.3%) dimensions and poor in financial satisfaction (71.8%) domain. In general, 89.5% of nurses had a high job security. The results of Pearson’s chi-square test showed a significant association between job security and gender, age, education and income variables. However, the findings of one-way ANOVA indicated no significant difference among different hospitals regarding the mean job security.Conclusion: The findings of this study demonstrated 89.5% of the studied participants were reported to have job security. Also, among the studied hospitals, Mohammad Kermanshahi hospital was found to have the highest job security.
Seasonality and food security among smallholder rural households in eastern Ethiopia: evidence from panel data analysis
Authors: Aweke Chanyalew Seyoum , Sassi Maria , Lahiff Edward , Wordofa Muluken G. 
Published: February 2020

Abstract
Food insecurity remains one of the major challenges in Ethiopia. There is scanty empirical evidence regarding the contribution of seasonality to household food and nutrition security. This study was conducted in eastern Ethiopia with the aim of examining seasonal household food and nutrition security and factors influencing this seasonal variation. Data was gathered from randomly selected households during pre- and post-harvest seasons. A Random Effects Generalized Least Squares (GLS) regression was employed for analysis. The result indicated considerable variation between the two seasons in terms of dietary diversity and food security. Households producing more food groups, cultivating larger size of land, having higher household income, keeping more livestock, owning cell phone, having access to cooperatives, and having access to improved drinking water as well as education were more likely to be more food secure across seasons. However, households keeping livestock in their dwelling units and households who had access to credit were negatively associated with seasonal food insecurity. Future interventions aiming at ensuring food security should pay attention to seasonality and mechanisms of improving diversified food production and household income as well as expanding education opportunities and access to cooperatives, infrastructure (mobile telephone) and sanitation.
A cerebellar neurocytoma with an excellent response to radiotherapy: a case report
Authors: Chen Siwei , Duan Hongzhou , Liu Ran , Luo Jingjing , Wang Hui , Zhang Shuang , Jin Haiqiang , Bai Jing , Gao Feng , Zhao Guiping , Huang Yining 
Published: February 2020

Abstract
Background: Extraventricular neurocytoma (EVN) is a rare central neurocytoma with neoplasms occurring in the brain parenchyma outside the ventricular system with similar biological behaviours and histopathological characteristics. Cases of EVN reported in the brainstem and cerebellum are fairly rare. In addition, very few cases with radiotherapy as the only treatment have been reported, and their outcomes were unclear.Case presentation: We reported an EVN of the brainstem and cerebellum confirmed by pathology in a 43-year-old male presenting with unprovoked nausea and dizziness. The patient showed a favourable outcome with only radiotherapy during the 2-year follow-up.Conclusions: Patients who have EVN may have a favourable prognosis with radiotherapy without surgery.
The effect of duration time on the efficacy and safety during endoscopic papillary balloon dilation for choledocholithiasis treatment
Authors: Wang Yining , Hao Yuanzhen , Qi Miao , Zuo Wei , Hong Jun-Bo 
Published: February 2020

Abstract
Background Endoscopic papillary balloon dilation (EPBD) has been widely accepted as an alternative to endoscopic sphincterotomy (EST) during therapeutic endoscopic retrograde cholangiopancreatography (ERCP) for choledocholithiasis treatment. No consensus has been established to define the precise duration of EPBD. Methods The PubMed, EMBASE, Cochrane Library database were systematically searched up to 31 May 2019 for research comparing short duration (≤ 30 seconds) and long duration (≥ 1 minute) of EPBD. Results Seven studies demonstrated that EPBD with long duration was superior than short duration in the stone clearance rate during the first ERCP (OR 0.61, 95%CI [0.48, 0.77], P < 0.001). Long duration exhibited a trend of higher efficacy in total stone removal across all ERCP sessions (OR 0.98, 95%CI [0.73, 1.31], P = 0.89), less frequency of mechanical lithotripsy use (OR 1.22, 95%CI [0.79, 1.89], P = 0.37). Compared with long duration, short balloon time had lower rate of overall complications (OR 0.85, 95%CI [0.70, 1.04], P = 0.11) and post-ERCP pancreatitis (OR 0.81, 95%CI [0.63, 1.03], P = 0.09). No significance was identified in hemorrhage (OR 0.86, 95%CI [0.30, 2.44], P = 0.77), perforation (OR 0.54, 95%CI [0.14, 2.14], P = 0.38) and cholangitis (OR 1.15, 95%CI [0.80, 1.66], P = 0.44). Conclusion Long duration (≥ 1 minute) could significantly increase the efficacy of EPBD in stone removal rate during first ERCP session, manifesting higher rate of total CBD stone clearance and less mechanical lithotripsy. Short EPBD contributed to less overall complications than long EPBD but not significantly.
Public health insurance and cancer-specific mortality risk among patients with breast cancer: a prospective cohort study in China
Authors: Xie yuxin , Valdimarsdóttir Unnur A. , Wang Chengshi , Zhong XiaoRong , Gou Qiheng , Zheng Hong , Deng Ling , He Ping , Hu Kejia , Fall Katja , Fang Fang , Tamimi Rulla M. , Luo Ting , Lu Donghao 
Published: February 2020

Abstract
Background Little is known about how health insurance policies, particularly in developing countries, may influence breast cancer prognosis. We aimed to examine the association between individual health insurance plans and breast cancer-specific mortality among patients in China.Methods We included 7,436 women diagnosed with invasive breast cancer between January 1 st , 2009, and December 31 st , 2016, at West China Hospital, Sichuan University. The health insurance plan of each patient was classified as either urban or rural schemes and was also categorized as reimbursement rate (i.e., the covered/ total charge) below or above the median. Breast cancer-specific mortality was the primary outcome. Using Cox proportional hazards models, we calculated hazard ratios (HRs) for cancer-specific mortality, contrasting rates among patients with a rural insurance scheme or low reimbursement rate to that of those with an urban insurance scheme or high reimbursement rate, respectively.Results During the median follow-up of 3.1 years, we identified 326 deaths due to breast cancer. Compared with patients covered by urban insurance schemes, patients covered by rural insurance schemes had a 29% increased cancer-specific mortality (95% CI 0% to 65%, P=0.046) after adjusting for demographics, tumor characteristics, and treatment modes. Reimbursement rate below the median was associated with a 42% increased rate of cancer-specific mortality (95% CI 11% to 82%). Every 10% increase in the reimbursement rate is associated with a 7% (95% CI, 2% to 12%) reduction in cancer-specific mortality risk, particularly in patients covered by rural insurance schemes (26%, 95% CI 9% to 39%).Conclusions Our findings suggest that under-insured patients with breast cancer in China face increased breast cancer-specific mortality, which may provide fresh insights into the role of reimbursement rate in cancer health disparities.
Advanced T stage and thick rectus abdominis muscle triggers outlet obstruction and high-output stoma following ileostomy in patients with rectal cancer
Authors: Komatsu Yasuhiro , Shigeyasu Kunitoshi , Mori Yoshiko , Takahashi Kazutaka , Hata Nanako , Takeda Sho , Kakiuchi Yoshihiko , Kikuchi Satoru , Yano Shuya , Kuroda Shinji , Kondo Yoshitaka , Teraishi Fuminori , Kagawa Shunsuke , Fujiwara Toshiyoshi 
Published: February 2020

Abstract
Background Ileostomy creation is an excellent approach to prevent leakage in patients undergoing low anterior resection for the treatment of rectal cancer. However, the two major complications of ileostomy are outlet obstruction and high-output stoma, and these complications remain unavoidable postoperative problems of ileostomy. Methods Risk factors associated with outlet obstruction and high-output stoma were retrospectively analyzed. The study included 83 patients with rectal cancer who underwent surgery. Of these patients, 34 underwent ileostomy creation. Results We found that outlet obstruction and high-output stoma were highly related (p = 0.03). Additionally, a thick rectus abdominis muscle and advanced T stage were the common risk factors of outlet obstruction (p = 0.0005 and p = 0.01, respectively) and high-output stoma (p = 0.04 and p = 0.03, respectively). Conclusions Our findings suggest that rectus abdominis muscle thickness and advanced T stage are predictive markers of outlet obstruction and high-output stoma.
In vitro antiviral activity of Echinaforce®, an Echinacea purpurea preparation, against common cold coronavirus 229E and highly pathogenic MERS-CoV and SARS-CoV
Authors: Signer Johanna , Jonsdottir Hulda R. , Albrich Werner C. , Strasser Marc , Züst Roland , Ryter Sarah , Ackermann-Gäumann Rahel , Lenz Nicole , Siegrist Denise , Suter Andreas , Schoop Roland , Engler Olivier B. 
Published: February 2020

Abstract
Coronaviruses (CoVs) were long thought to only cause mild respiratory and gastrointestinal symptoms in humans but recent outbreaks of Middle Eastern Respiratory Syndrome (MERS)-CoV, Severe Acute Respiratory Syndrome (SARS)-CoV, and the newly identified SARS-CoV-2 have cemented their zoonotic potential and their capacity to cause serious morbidity and mortality, with case fatality rates ranging from 2 to 35%. Currently, no specific prophylaxis or treatment is available for CoV infections and therefore we investigated the antiviral potential of Echinacea purpurea (Echinaforce®) against human coronavirus (HCoV) 229E and the highly pathogenic MERS- and SARS-CoVs in vitro. We found that HCoV-229E was irreversibly inactivated when exposed to Echinaforce at 3.2µg/ml IC50. Pre-treatment of cell lines, however, did not inhibit infection with HCoV-229E and post-infection treatment had only a marginal effect on virus propagation at 50 µg/ml. However, we did observe a protective effect in an organotypic respiratory cell culture system by exposing pre-treated respiratory epithelium to droplets of HCoV-229E, imitating a natural infection. Finally, antiviral activity was not restricted to common cold coronaviruses, as the highly pathogenic SARS- and MERS-CoVs were inactivated at comparable concentrations. These results suggest that Echinacea purpurea preparations, such as Echinaforce, could be effective as prophylactic treatment for all CoVs, including newly occurring strains, such as SARS-CoV-2.
A Comparative Study of the Gut Microbiota Associated with Immunoglobulin A Nephropathy and Membranous Nephropathy
Authors: sun shiren , Dong Ruijuan , Bai Ming , Zhao Jin , Wang Di , Ning Xiaoxuan 
Published: February 2020

Abstract
Background The pathogenesis of immunoglobulin A nephropathy (IgAN) and membranous nephropathy (MN) is characterized by immune dysregulation, which is related to gut dysbiosis. The aim of the study was to compare the gut microbiota of patients with IgAN and MN versus healthy controls. We used 16S rDNA amplicon sequencing to investigate the bacterial communities of 44 patients with kidney biopsy-proven IgAN, 40 patients with kidney biopsy-proven MN, and 30 matched healthy controls (HC). Results The abundance of Escherichia-Shigella and Defluviitaleaceae_incertae_sedis were significantly higher in IgAN than in HC, whereas lower abundances were observed for Roseburia, Lachnospiraceae_ unclassified, Clostridium_sensu_stricto_1, and Fusobacterium . Furthermore, the abundance of Escherichia-Shigella, Peptostreptococcaceae_incertae_sedis , Streptococcus, and Enterobacteriaceae_ unclassified increased, while that of Lachnospira, Lachnospiraceae_ unclassified, Clostridium_sensu_stricto_1, and Veillonella decreased in MN. The abundance of Megasphaera and Bilophila was higher, whereas that of Megamonas, Veillonella, Klebsiella, and Streptococcus was lower in patients with IgAN than in those with MN. Analysis of the correlations showed that in the IgAN group, Prevotella was positively correlated, while Klebsiella , Citrobacter, and Fusobacterium were negatively correlated with the level of serum albumin. Positive correlation also existed between Bilophila and Crescents in the Oxford classification of IgAN. In the MN group, negative correlation was observed between Escherichia-Shigella and proteinuria, Bacteroides and Klebsiella showed positive correlation with the MN stage. Conclusions Patients with IgAN and MN exhibited gut microbial signatures distinct from healthy controls. Our study suggests the potential of gut microbiota as specific biomarker and contributor in the pathogenesis of IgAN and MN.
Kaonic atoms experiment at the DAΦNE collider by SIDDHARTA/SIDDHARTA-2
Authors: Skurzok Magdalena , Amirkhani Abdollah , Baniahmad A. , Bazzi M. , Bosnar D. , Bragadireanu M. , Carminati M. , Cargnelli M. , Clozza A. , Curceanu Catalina , De Paolis L. , Del Grande Rafael , Fabbietti Laura , Fiorini C. , Guaraldo C. , Iliescu Mariana , Iwasaki M. , Levi Sandri P. , Marton Johann , Miliucci Marco , Moskal Pawel , Niedźwiecki Szymon , Okada Susumu , Pietreanu D. , Piscicchia Kristian , Scordo Alessandro , Silarski MIchal , Sirghi Diana , Sirghi F. , Spallone Antonio , Tüchler M. , Vazquez Doce Oton , Widmann Eberhard , Zmeskal Johann 
Published: February 2020

The excellent quality kaon beam provided by the
DA\PhiΦNE
collider of LNF-INFN (Italy) together with SIDDHARTA/SIDDHARTA-2 new
experimental techniques, as very precise and fast-response X-ray
detectors, allow to perform unprecedented measurements on light kaonic
atoms crucial for a deeper understanding of the low-energy quantum
chromodynamics (QCD) in the strangeness sector. In this paper an
overview of the main results obtained by the SIDDHARTA collaboration, as
well as the future plans related to the SIDDHARTA-2 experiment, are
discussed.
Plastics: physical-and-mechanical properties and biodegradable potential
Authors: Glukhikh Viktor , Buryndin Pavel , Artyemov Artyem , Savinovskih Andrei , Krivonogov Pavel , Krivonogova Anna 
Published: February 2020

Introduction. Processing agricultural waste into plant biodegradable plastics is a promising way for its recycling. This work featured the main physical-and-mechanical properties of plant plastics without adhesive substances obtained from millet husk and wheat husk and wood plastic obtained from sawdust, as well as their biodegradation potential.
Study objects and methods. Objects of the study were plastics without adhesives based on wood sawdust, millet husk, and wheat husk.
Results and discussion. We analyzed of the physical-and-mechanical parameters of the plant plastic based on millet husk, wheat husk, as well as wood plastic based on sawdust. The analysis showed that, in general, the strength characteristics of the wood plastics were higher than those of the plastics based on millet husk, especially flexural strength. Thus, the average value of the density of the wood plastic exceeded that of the plant plastic from millet husk by 10%, hardness by 40%, compression elasticity modulus by 50%, and flexural modulus by 3.9 times. It was found that wood and plant plastics obtained from sawdust, millet husk, and wheat husk without adhesives had a high biodegradation potential.
Conclusion. The plastics obtained can be used as an insulating, building, and decorative material in the steppe regions experiencing a shortage of wood and wood powder.
Antioxidant and antimicrobial properties of oregano extract (Origani vulgaris herba L.)
Authors: Oleynikov Vladislav 
Published: February 2020

Introduction. Some ingredients of plant origin possess both antioxidant and bacteriostatic properties. If used in the food industry, they can inhibit microbiological and oxidative damage, thus increasing the shelf life of meat products. Oregano extract is one of such substances, which means that it can be used as an antioxidant and preservative. Therefore, the study of this plant has a significant theoretical and practical potential for the food industry.
Study objects and methods. The present research featured ground trimmed beef. The samples with 20% of fat tissue were used to determine the microbiological parameters, while the samples with 30% of fat were used to obtain data on oxidative stability. The control sample contained no additional ingredients. The sample with food additives was pre-treated with acidity regulators and antioxidants, namely sodium acetate E262, ascorbic acid E300, sodium ascorbate E301, sodium citrate E331, and rosemary extract E392. The sample with oregano extract was pre-treated with oregano extract (Origani vulgaris herba L.) in the ratio of 5 g of extract per 1 kg of meat. The extract had been dissolved in 100 g of water. The samples were stored at 4 ± 2°C for 12 days. A CM5 spectrophotometer (Konica Minolta, Japan) was used to determine the color characteristics. The induction period of oxidative stability was determined using an Oxitest oxidative stability analyzer (Velp Scientifica, Italy). The studies were conducted in Austria, Linz.
Results and discussion. Oregano extract stabilized the redness rating. For the sample with oregano extract, the induction period of oxidative stability was twice as long as for the control sample and the sample with antioxidants. In addition, oregano inhibited the growth of aerobic and anaerobic microorganisms.
Conclusion. The antioxidant and antimicrobial properties of oregano extract prolong the shelf life of ground beef, which makes it possible to reduce the amount of food additives.
Multiscale variability of streamflow in the Three Rivers Headwater Region, China, and links to large-scale atmospheric circulation indices
Authors: Tang Jian , Cao Huiqun 
Published: February 2020

Abstract
Exploring the relations between streamflow and large-scale atmospheric circulation systems can assist in identifying potentially useful indicators for the modeling of hydrological processes. With the help of ensemble empirical mode decomposition and the wavelet analysis method, this research explored streamflow variations and its links to large-scale atmospheric circulation indices during 1960–2012 in the Three Rivers Headwater Region (TRHR). A steady increasing trend was detected in the streamflow of the source region of Yangtze River (SYR), and a steady decreasing trend was detected in the streamflow of the source region of Lancang River (SLR). The streamflow of the source region of Yellow River (SYeR) had an increasing trend in the early years of the study period and subsequently exhibited a decreasing trend. The Tibetan Plateau monsoon (TPM), Arctic Oscillation (AO), and South Asia monsoon (SAM) are the key factors influencing streamflow changes in the SYR, SYeR, and SLR, respectively. At interannual time-scale variation with the period of about 3–9 years, an antiphase relationship exists between SYR streamflow and TPM indices, while in-phase relationships are detected between SYeR (SLR) streamflow and AO (SAM) indices.