bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research priority setting in women’s health: a systematic review
Authors: Graham L , Illingworth BJG , Showell M , Vercoe M , Crosbie EJ , Gingel LJ , Farquhar CM , Horne AW , Prior M , Stephenson JM , Magee LA , Duffy JMN 
Published: February 2020

BackgroundDeveloping a shared agenda is an important step in ensuring future research has the necessary relevance.ObjectiveTo characterise research priority setting partnerships (PSPs) relevant to women’s health.Search strategyIncluded studies were identified by searching MEDLINE and the James Lind Alliance (JLA) database.Selection criteriaPriority setting partnerships using formal consensus methods.Data collection and analysisDescriptive narrative to describe the study characteristics, methods, and results.Main resultsTen national and two international PSPs were identified. All PSPs used the JLA method to identify research priorities. Nine PSPs had published a protocol. Potential research uncertainties were gathered from guidelines (two studies), Cochrane reviews (five studies), and surveys (12 studies). The number of healthcare professionals (31–287), patients (44–932), and others (33–139) who responded to the survey, and the number of uncertainties submitted (52–4767) varied. All PSPs entered confirmed research uncertainties (39–104) into interim priority setting surveys and healthcare professionals (31–287), patients (44–932), and others (33–139) responded. All PSPs entered a short list of research uncertainties into a consensus development meeting, which enabled healthcare professionals (six to 21), patients (eight to 14), and others (two to 13) to identify research priorities (ten to 15). Four PSPs have published their results.ConclusionFuture research priority setting studies should publish a protocol, use formal consensus development methods, and ensure their methods and results are comprehensively reported.Tweetable abstractResearch published in @BJOGtweets highlights future research priorities across women’s health, including @FertilityTop10, @jamesmnduffy.
Outcome of children relapsing after first allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia: a retrospective I‐BFM analysis of 333 children
Authors: Uden Theodor , Bertaina Alice , Abrahamsson Jonas , Ansari Marc , Balduzzi Adriana , Bourquin Jean‐Pierre , Gerhardt Corinne , Bierings Marc , Hasle Henrik , Lankester Arjan , Mischke Kirsten , Moore Andrew S. , Nivison‐Smith Ian , Pieczonka Anna , Peters Christina , Sedlacek Petr , Reinhardt Dirk , Stein Jerry , Versluys Birgitta , Wachowiak Jacek , Willems Leen , Zimmermann Martin , Locatelli Franco , Sauer Martin G. 
Published: February 2020

SummaryOutcome of 333 children with acute myeloid leukaemia relapsing after a first allogeneic haematopoietic stem cell transplantation was analyzed. Four‐year probability of overall survival (4y‐pOS) was 14%. 4y‐pOS for 122 children receiving a second haematopoietic stem cell transplantation was 31% and 3% for those that did not (P = <0·0001). Achievement of a subsequent remission impacted survival (P = <0·0001). For patients receiving a second transplant survival with or without achieving a subsequent remission was comparable. Graft source (bone marrow vs. peripheral blood stem cells, P = 0·046) and donor choice (matched family vs. matched unrelated donor, P = 0·029) positively impacted survival after relapse. Disease recurrence and non‐relapse mortality at four years reached 45% and 22%.
Time‐varying risk of rare disasters, investment, and asset pricing
Authors: Liu Bo , Niu Yingjie , Yang Jinqiang , Zou Zhentao 
Published: February 2020

AbstractWe extend an equilibrium business cycle/asset pricing model of production and capital accumulation by introducing a time‐varying risk of rare disasters. It predicts that investment is much more volatile than output, which provides theoretical support for the empirical data. Furthermore, the model‐generated stationary distribution of the investment‐output ratio fits the data remarkably well. Both of them exhibit negative skewness, which means that there is a small probability that this ratio can be very low. Given the observations of the investment‐output ratio, we obtain the values of the jump intensity implicit in the historical data and find those recession periods coincide with a rapid increase in the probability of a disaster. Finally, the model shows that the existence of adjustment costs generates a procyclical price of capital and contributes to resolving the equity premium puzzle.
Time‐varying relationships between ocean conditions and sockeye salmon productivity
Authors: Malick Michael J. 
Published: February 2020

AbstractEnvironmental change is occurring at unprecedented rates in many marine ecosystems. Yet, environmental effects on fish populations are commonly assumed to be constant across time. In this study, I tested whether relationships between ocean conditions and productivity of North American sockeye salmon (Oncorhynchus nerka) stocks have changed over the past six decades. Specifically, I evaluated the evidence for non‐stationary relationships between three widely used ocean indices and productivity of 45 sockeye salmon stocks using hierarchical Bayesian models. The ocean indices investigated were the Pacific Decadal Oscillation (PDO), North Pacific Gyre Oscillation (NPGO), and sea surface temperature (SST). I found partial support for time‐varying salmon–ocean relationships. Non‐stationary relationships were strongest for the NPGO and weaker for the SST and PDO indices. Productivity–NPGO correlations tended to shift gradually over time with opposite trends for stocks in British Columbia (B.C.) and western Alaska; for B.C. stocks, the NPGO correlations shifted from significantly negative prior to 1980 to significantly positive after 1990, whereas for western Alaska stocks, the correlations shifted from positive to negative. Productivity–SST correlations showed declining trends for B.C. and Gulf of Alaska stocks, that is, correlations became more negative (B.C.) or less positive (Gulf of Alaska) over time. For the PDO, correlations weakened during the 1980s for western Alaska and B.C. stocks. Overall, these results provide evidence for time‐varying relationships between salmon productivity and environmental conditions over six decades, highlighting the need to recognize that historical responses of salmon populations to environmental change may not be indicative of future responses.
Global prevalence of aggressive periodontitis: A systematic review and meta‐analysis
Authors: Bouziane Amal , Hamdoun Radia , Abouqal Redouane , Ennibi Oumkeltoum 
Published: February 2020

AbstractAimThe prevalence of aggressive periodontitis (AgP) varies considerably between studies. The aim of this meta‐analysis was to estimate, throughout the world, the prevalence of this disease.Materials and MethodsPubmed/Medline, Scopus, Science Direct, EBSCO and Cochrane library were systematically searched up to March 2018. Study selection criteria included cross‐sectional studies reporting prevalence of AgP in non‐specific population and permanent dentition. We assessed risk of bias using the Joanna Briggs Institute tool. A random effect meta‐analysis model was used to estimate the prevalence of AgP. Publication bias was assessed by Begg and Egger's tests and visual aspect of funnel plot.ResultsA total of 33 articles were included. Pooled prevalence for AgP was 1.6% (95% CI 1.1–2.3). Higher pooled prevalence rates were reported in Africa (4.2%, 95% CI 2.0–7.1) and South America (4.0%, 95% CI 0.9–9.1) compared with Europe (0.1%, 95% CI 0.1–0.2). A pooled prevalence of 1.2%, 95% CI 0.5–2.2 was found in Asia and 0.8%, 95% CI 0.4–1.4 in North America. Heterogeneity between groups was statistically significant (Q statistic p < .001).ConclusionsA relatively high prevalence of AgP was found in Africa. However, the data support the weakness of the definition of this form of periodontal disease. Studies with less heterogeneity are needed to address accurately the prevalence of AgP.
Extracellular vesicles and melatonin benefit embryonic develop by regulating reactive oxygen species and 5‐methylcytosine
Authors: Qu Pengxiang , Luo Shiwei , Du Yue , Zhang Yanru , Song Xiaojie , Yuan Xuetao , Lin Zujie , Li Yuchen , Liu Enqi 
Published: February 2020

AbstractEmbryo culture conditions are crucial as they can affect embryo quality and even offspring. Oviductal extracellular vesicles (EVs) long been considered a major factor influencing interactions between the oviduct and embryos, and thus its absence is associated with inferior embryonic development in in vitro culture. Herein, we demonstrated that melatonin is present in oviduct fluids and oviduct fluid‐derived EVs. Addition of either EVs (1.87 × 1011 particles/mL) or melatonin (340 ng/mL) led to a significant downregulation of reactive oxygen species (ROS) and 5‐methylcytosine (5‐mC), as well as an increase in the blastocyst rate of embryos, which was inhibited by the addition of luzindole—a melatonin receptor agonist. A combination of EVs (1.87 × 1010 particles/mL) and melatonin (at 34.3 pg/mL) led to the same results as well as a significant decrease in the apoptosis index and increase in the inner cell mass (ICM)/trophectoderm (TE) index. These results suggest that an EV‐melatonin treatment benefits embryonic development. Our findings provide insights into the role of EVs and melatonin during cell communication and provide new evidence of the communication between embryos and maternal oviduct.
Factors associated with internalized stigma for Indonesian individuals diagnosed with schizophrenia in a community setting
Authors: Pribadi Teguh , Lin Esther C.‐L. , Chen Po‐See , Lee Shih‐Kai , Fitryasari Reziki , Chen Chih‐Hsuan 
Published: February 2020

Accessible summaryWhat is known on the subject?

Internalized stigma in people diagnosed with mental illness has several negative outcomes; however, it remains unclear in an Indonesian context.

The human rights of people diagnosed with mental illness in Indonesia have been routinely violated because of the existing stigma against mental illness and deficiencies in the country's mental healthcare services.

What the paper adds to existing knowledge?

To the best of our knowledge, this is the first study to examine the level of internalized stigma and related factors among Indonesians diagnosed with schizophrenia.

Almost one‐third of the subjects had moderate‐to‐severe levels of internalized stigma, among which discrimination was the strongest type.

Specifically, younger and unemployed people with more psychotic symptoms had higher levels of internalized stigma.

What are the implications for practice?

The provision of adequate pharmacological and psychosocial treatments to help people manage their psychotic symptoms is extremely important to ameliorate stigma.

Vocational rehabilitation and employment support for unemployed people may potentially reduce their internalized stigma and promote recovery.

AbstractIntroductionThe human rights of people diagnosed with mental illness in Indonesia have been routinely violated because of societal stigma associated with mental illness and deficiencies in the country's mental healthcare services. Knowledge about internalized stigma among people diagnosed with schizophrenia in lower middle‐income Muslim countries is also scarce.AimTo identify the level of internalized stigma and related factors among people diagnosed with schizophrenia in Indonesia.MethodA cross‐sectional survey was conducted with a purposive sample of 300 people diagnosed with schizophrenia from an urban Indonesian psychiatric hospital.ResultsAlmost one‐third of the subjects had moderate‐to‐severe levels of internalized stigma, among which discrimination was the strongest type. Younger age, unemployment status and having psychotic symptoms significantly increased the risk of internalized stigma when analysed in a multivariable ordinal logistic regression.DiscussionThe present study firstly identified the high levels of internalized stigma among Indonesian individuals diagnosed with schizophrenia.Implications for practiceMental health nurses are suggested to provide early anti‐stigma illness management and family psychoeducation interventions to people diagnosed with schizophrenia and their family caregivers, helping them to develop an optimistic understanding about the concept of schizophrenia and mitigating the negative consequences of public and internalized stigma.
Exploratory analysis of anti‐insulin antibodies in diabetic dogs receiving recombinant human insulin
Authors: Lester M. , O'Kell A. L. 
Published: February 2020

ObjectivesTo quantify anti‐insulin antibodies in diabetic dogs treated with recombinant human insulin and to determine if insulin dosage or duration of treatment differed between anti‐insulin antibody‐positive and ‐negative diabetic dogs.Materials and MethodsDescriptive preliminary study using serum from 24 client‐owned diabetic dogs treated for a minimum of 2 weeks with recombinant human insulin, and 24 client‐owned healthy control dogs without diabetes. Sera were analysed by radioimmunoassay for anti‐insulin antibodies. The proportion of antibody positive dogs was compared between groups by Fisher's exact test.ResultsFour diabetic (16.6%) and no control dogs were anti‐insulin antibody positive.Clinical SignificanceThese results indicate that treatment with recombinant human insulin may induce anti‐insulin antibodies in dogs, although this finding needs to be re‐investigated in a larger study to investigate the impact of anti‐insulin antibodies on glycaemic control.
A Comparison of the external anatomical landmark and the radiological landmark for obtaining the optimal depth of a right internal jugular venous catheter in pediatric cardiac patients
Authors: Samerchua Artid , Kongwatmai Kritanon , Boonsri Settapong , Pipanmekaporn Tanyong , Bunchungmongkol Nutchanart , Sukhupragarn Wariya , Visrutaratina Pannee 
Published: February 2020

AbstractBackgroundThe external anatomical landmark and the radiological landmark have been introduced to provide estimation of the depth of right internal jugular venous catheter during insertion.AimsThis study aimed to compare the accuracy, agreement, and reliability of the external anatomical landmark and the radiological landmark, confirmation being by transesophageal echocardiography.MethodsThis prospective observational study was conducted in children ages 1‐15 years. The catheter was placed at the superior vena cava and the right atrium junction guided by transesophageal echocardiography. The catheter depth derived from the transesophageal echocardiography, the external anatomical landmark, and the radiological landmark was recorded. The optimal zone of the catheter tip was 5 mm below and 10 mm above the superior vena cava and the right atrium junction. Accuracy was assessed by the difference between the transesophageal echocardiography and the external anatomical landmark or the radiological landmark. Agreement with Bland‐Altman plots and correlation were tested.ResultsEighty participants, median age of 3 years, were enrolled. The median (IQR) differences between the depth of the transesophageal echocardiography and the external anatomical landmark or the radiological landmark were 0.30 (0, 0.70) and 0.10 (−0.20, 0.90) cm, respectively. Bland‐Altman plots demonstrated good agreement between the depths. The catheter tips were located in the optimal zone more frequently with the external anatomical landmark than the radiological landmark (94.7% vs 64.5%). The external anatomical landmark showed a stronger correlation to transesophageal echocardiography than the radiological landmark (r = .95 vs .83).ConclusionBoth the external anatomical landmark and the radiological landmark enabled accurate estimation of the central venous catheter depth close to the superior vena cava and the right atrium junction. The external anatomical landmark is of more potential use than the radiological landmark in clinical practice.
The relative importance of phylogeny and habitat in determining the presence and prominence of a granula iridica in hooved mammals
Authors: Weyna Alisia , Dubielzig Richard R. , Hennelly Lauren 
Published: February 2020

AbstractPurposeTo investigate the relationship between phylogeny and amount of shade in a species’ habitat regarding the presence or absence of an iridal granula iridica (GI) in a large sample of Artiodactyl and Perissodactyl clades and using online resources.MethodsThe Comparative Ocular Pathology Laboratory of Wisconsin (COPLOW) archives were searched for glass slide material from Artiodactyl (even‐toed) and Perissodactyl (odd‐toed) ungulates. The slides were examined, and the presence or absence of the GI was noted. The phylogenetic tree of the ungulate species was inferred using TimeTree (http://www.timetree.org), and the habitat data are derived from Animal Diversity Web (https://animaldiversity.org/). We assessed the probability of the presence of GI occurring given the amount of shade in a species’ environment using phylogenetic logistic regression.ResultsForty‐eight artiodactyl species were able to be evaluated and tabulated. Nine perissodactyl species were able to be evaluated. The phylogenetic logistic regression showed that the probability of GI presence was lower in artiodactyl species that inhabited shaded environments (βshaded = −1.774). Arctiodacyl species inhabiting a nonshaded environment were slightly more probable to have the GI present (βnonshaded = 0.023), with species inhabitating ambiguously shaded environments having a high probability of GI presence (βambiguous = 2.214).ConclusionsOur results suggest that the GI may be a common morphological feature to shade the pupil in nonshaded environments, and, in its absence, increase the amount of light reaching the retina to improve vision in shaded environments for hooved mammals. Further research on the functional optics of the GI and studies that include additional ungulate species would further elucidate phylogenetic and ecological factors influencing the occurrence of GI in hooved mammals.
Distribución de los niveles séricos de amilasa en pacientes con leishmaniasis cutánea en tratamiento con antimoniato de meglumina
Authors: Rodríguez Ángela Johanna , Macías Eva Lucía 
Published: February 2020

El tratamiento de elección para la leishmaniasis es el antimoniato de meglumina, del cual se han reportado efectos pancreáticos. Se llevó a cabo un estudio con 90 pacientes entre agosto de 2010 y abril de 2011, y se observó la variabilidad de la amilasa al inicio, la mitad y el final del tratamiento con dosis de 20 mg/kg al día. Los promedios fueron: peso, 68±9,1 kg, edad, 24,73±4,45 años, y dosis del medicamento, 28,15±3,97 g. El sitio de lesión más frecuente fue en miembros superiores (44,4%). No hubo asociación significativa entre las variables peso, edad y gramos de medicamento. Se presentó alteración en 49,37% a la mitad de tratamiento y en 6,5% al final. Existen diferencias significativas en la amilasa reportada a mitad de tratamiento respecto a las dos tomas (p=0,000). En conclusión, se debe controlar la amilasa sérica, ya que se eleva, especialmente, a mitad de tratamiento.
Organizaciones inteligentes: evidencia empírica de una organización que aprende en Colombia (Hospital Universitario San Ignacio)
Authors: Duque Orozco Yenni Viviana , Castro-García Andrés Guillermo 
Published: February 2020

El artículo se centra en la relevancia de conectar tanto el aprendizaje organizativo como la gestión del conocimiento con la implantación de prácticas de dirección de recursos humanos con un alto compromiso. A partir de estas ideas, se analiza el caso del Hospital Universitario San Ignacio y cómo pasaron de rojo a negro sus resultados financieros mediante una estrategia innovadora de intervención administrativa integral y mediante unas pautas empíricas basadas en dicha experiencia desde el direccionamiento del conocimiento y del talento humano. Se concluye que el Hospital Universitario San Ignacio se ha convertido en el ejemplo palpable de que una adecuada administración y un sentido de trabajo basados en el talento humano y en su efectividad al momento de la resolución de conflictos es el camino para conseguir una organización inteligente en el área de salud, establecida en la generación de conocimiento y en la estrategia de mejoramiento continuo.
Aspectos generales del síndrome de dolor crónico posquirúrgico. Revisión sistemática-cualitativa
Authors: Ricaurte Gracia Laura Nathaly , Rey Rodríguez Andrés Felipe , Ovalle Marroquín Diego Fernando 
Published: February 2020

Introducción: El dolor crónico posquirúrgico (DCP) es motivo frecuente de consulta, tiene alta prevalencia y es incapacitante. Dura entre dos y tres meses, y su causa se limita a una cirugía previa sin importar su indicación o técnica.Métodos: Se realizó una búsqueda bibliográfica en Medline, Embase y LILACS sin límites de idioma ni diseño, en procura de evidencias entre enero de 1990 y febrero de 2011. Se incluyeron artículos que trataran algún aspecto del DCP. La calidad de la información se evaluó con herramientas del Critical Appraisal Skills Programme (CASP-UK).Resultados: El DCP se asocia a la intensidad del dolor agudo postoperatorio y factores psicosociales del paciente. Algunas cirugías se asocian más. Analgesia preoperatoria, medicación del dolor agudo y la anestesia epidural son pilares para prevenir y disminuir la incidencia.Conclusiones: Son necesarios más estudios primarios sobre prevención y tratamiento del DCP, pues son escasos los reportes con calidad adecuada.
Trisomía 13 y sus alteraciones placentarias. Reporte de caso
Authors: Olaya Contreras Mercedes , Zarante Ana 
Published: February 2020

Las alteraciones cromosómicas son una importante causa de muerte en humanos. Su diagnóstico cuenta con nuevas herramientas que están cada vez más al alcance y permiten correlacionar los hallazgos de los estudios fetales y placentarios; sin embargo, no en todas las instituciones de salud colombianas se cuenta con tales recursos. Se reporta un caso de trisomía 13, corroborada por hibridación fluorescente in situ (FISH) y se analizan las manifestaciones histológicas encontradas en la placenta, la cual sí puede ser estudiada de manera rutinaria.
Teoría de la compuerta (Ronald Melzack y Patrick D. Wall, 1965)
Authors: Acevedo González Juan Carlos 
Published: February 2020

El conocimiento del dolor ha tenido momentos cruciales en los que el curso evolutivo se modificó y que cambiaron los conceptos aceptados y abrieron nuevos horizontes de investigación, entendimiento y tratamiento. Cuando Melzack y Wall desarrollaron la teoría de la compuerta aclararon fenómenos básicos del entendimiento del dolor y sustentaron múltiples tratamientos, que son la base de procedimientos actuales. Son cincuenta años que se cumplen de la publicación de aquel artículo en la revista Science (“Pain Mechanism: A New Theory. A Gate Control System Modulates Sensory Input from the Skin before it Evoques Pain Perception and Response”). Este se escribió en un contexto científico particular y a la luz de dos vidas diferentes que ilustran un proceso ejemplar de desarrollo de la ciencia. El análisis, aquí presentado, es no solo científico, sino humano de lo que ha sido este artículo para el entendimiento de las ciencias del dolor.
Cutting the Carbon from Concrete
Authors: Siegel R.P. 
Published: February 2020

Abstract
The production of concrete is responsible, by some estimates, for as much as 10 percent of global carbon dioxide emissions, enough to be considered a major contributor. Given the impact that has now become apparent, research teams around the world are pursuing a number of impressive and effective technologies to reduce the carbon footprint of concrete production and use as a top priority. Some are being deployed cost-effectively today, while other, potentially even better solutions, are being developed in labs. This article delves deeper into some of these solutions and the challenges in their adoption.