bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lactoferrin Suppresses Decreased Locomotor Activities by Improving Dopamine and Serotonin Release in the Amygdala of Ovariectomized Rats
Authors: Izumo Nobuo , Yukiko Ishibashi , Kagaya Nobuharu , Furukawa Megumi , Iwasaki Rina , Sumino Akihide , Hayamizu Kohsuke , Nakano Makoto , Hoshino Tatsuo , Kurono Haruna , Watanabe Yasuo , Manabe Takayuki 
Published: April 2020

Background:
Decreases in female hormones not only affect bone metabolism and decrease bone mass,
but also affect the central nervous system, causing brain disorders such as depression and dementia. Administration
of estradiol by hormone replacement therapy can improve dementia, while reduced estradiol in ovariectomized
(OVX) model rats can reduce both bone density and locomotor activity. The antidepressant fluvoxamine, which is
widely used in clinical practice, can improve this effect on locomotor reduction. Similarly, lactoferrin (LF) can
reportedly improve inhibitory locomotion due to stress.

Objective:
In this study, we examined the effect of LF on neurite outgrowth in vitro and in vivo using PC12 cells and
rats, respectively.

Methods:
We performed an in vivo study in which 8-week-old female OVX rats were administered LF five days a
week for 6 weeks from the day after surgery. After administration was completed, spontaneous locomotor activity in
the dark period, immobility time in a forced swim test, and release amount of dopamine and serotonin in the brain
were measured.

Results:
LF was found to have a neurite outgrowth function in PC12 cells. Moreover, LF was found to improve
OVX-induced decreases in locomotor activity and increases in immobility time in the forced swim test. Furthermore,
administration of LF elicited significant recovery of decreased dopamine and serotonin release in the brains of OVX
group rats.

Conclusion:
These results strongly suggest that LF improved OVX-induced decreases in momentum during the dark
period and, moreover, that release of dopamine and serotonin in the brain was involved in this effect.
Biomedical Applications and Patents on Metallic Nanoparticles
Authors: Singh Geetanjali , Sharma Pramod K. , Malviya Rishabha 
Published: April 2020

Aim:
The manuscript aims to discuss the advanced biomedical applications and patents
on metallic nanoparticles.

Discussion:
The preparation of metallic nanoparticles and their application are an influential area
for research. There are various physical and chemical methods (viz. chemical reduction, thermal
decomposition, etc.) for synthesizing silver nanoparticles; biological methods have been suggested
as possible eco-friendly alternatives. The synthesis of metallic nanoparticles encounters many
problems including solvent toxicity, the formation of hazardous by-products and consumption of
energy. So it is important to design eco-friendly benign procedures for the synthesis of metallic
nanoparticles. It is investigated from the study that metallic nanoparticles are used in the treatment
of different diseases. Metallic nanoparticles are also used in the detection and therapy of cancer.
These also have antifungal, antibacterial, anti-inflammatory, antiviral and anti-angiogenic properties.

Conclusion:
It is concluded from the manuscript that the synthesis of metallic nanoparticles is
easy, eco-friendly, less time consuming and affordable. The metallic nanoparticles used in the biomedical
field have an emerging future in nanoscience and nanotechnology.
Asupan Zat Gizi Dan Kadar Hemoglobin Wanita Prakonsepsi Di Kabupaten Semarang
Authors: Dieny Fillah Fithra , Maadi Annisa Khaira , Wijayanti Hartanti Sandi , Tsani A.Fahmy Arif , Nissa Choirun 
Published: April 2020

Abstrak Wanita prakonsepsi yang mengalami anemia berisiko mengalami berbagai masalah saat kehamilan. Salah satu faktor risiko anemia yaitu asupan zat gizi yang tidak adekuat. Penelitian ini bertujuan untuk menganalisis faktor asupan zat gizi yang berpengaruh terhadap kadar Hb wanita prakonsepsi. Penelitian ini menggunakan desainÂ cross-sectional dengan 70 subjek pengantin wanita di KUA Kecamatan Sumowono dan Pringapus, berusia 16-35 tahun, dipilih dengan metode consecutive sampling. Data yang diambil yaitu berat badan, tinggi badan, asupan makan, dan kadar hemoglobin. Data asupan makan diperoleh menggunakan Semi Quantitative Food Frequency Questionnaire (SQ-FFQ). Data kadar Hb diukur menggunakan metode Cyanmethemoglobin. Analisis data menggunakan uji regresi linear sederhana dan regresi linear ganda. Hasil penelitian menunjukkan bahwa prevalensi anemia dan status gizi kurang sebanyak 11,4% dan 15,7%. Asupan energi, protein, vitamin B2, seng, besi dan asam folat tergolong kurang. Asupan energi (p=0,004), protein (p=0,007), zat besi (p=0,009), dan status gizi (p=0,055) merupakan faktor yang mempengaruhi kadar Hb. Faktor yang paling berpengaruh terhadap kadar Hb adalah asupan energi dan status gizi. Kesimpulannya adalah kadar Hb pada wanita prakonsepsi dipengaruhi oleh asupan energi, protein, zat besi dan status gizi. Namun, faktor yang paling berpengaruh adalah asupan energi dan status gizi.Kata kunci: asupan zat gizi, hemoglobin, wanita prakonsepsiÂ Abstract Â Preconception women who have anemia are at risk of suffering problems during pregnancy. One of risk factors for anemia is inadequate nutrient intake. This study was aimed to analyze the factors of nutrient intakes that affect the level of Hb in preconception women. This study was conducted by using cross-sectional design study that consisted of 70 brides registered at Office of Religious Affairs in Sumowono and Pringapus Subdistricts, aged 16-35 years selected by consecutive sampling method. Weight, height, food intake, and hemoglobin level were measured. Food intake was obtained by using Semi Quantitative Food Frequency Questionnaire (SQ-FFQ). Hb level was measured by Cyanmethemoglobin method. Simple linear regression and multiple linear regression test were used to analyze the data. The result showed that the prevalence of anemia was 11,4% and prevalence of undernutrition status was 15,7%. Energy intake (p=0,004), protein intake (p=0,007), iron intake (p=0,009), nutritional status (p=0,055) were factors that affected Hb level. The most significantÂ factors of Hb level were energy intake and nutritional status. The conclussion is Hb level in preconception women was affected by energy, protein, iron intake and nutritional status. However, the most significant factors with Hb level were energy intake and nutritional status. Keywords: nutrients intake, hemoglobin, preconception women
An Instagram-Based Study to Understand Betel Nut Use Culture in Micronesia: Exploratory Content Analysis
Authors: Buente Wayne , Dalisay Francis , Pokhrel Pallav , Kramer Hanae Kurihara , Pagano Ian 
Published: April 2020

Background
A 2012 World Health Organization report recognizes betel nut use as an urgent public health threat faced by the Western Pacific region. However, compared with other addictive substances, little is known about how betel nuts are depicted on social media platforms. In particular, image-based social media platforms can be powerful tools for health communication. Studying the content of substance use on visual social media may provide valuable insights into public health interventions.

Objective
This study aimed to explore and document the ways that betel nut is portrayed on the photo-sharing site Instagram. The analysis focuses on the hashtag #pugua, which refers to the local term for betel nut in Guam and other parts of Micronesia.

Methods
An exploratory content analysis of 242 Instagram posts tagged #pugua was conducted based on previous research on substance use and Instagram and betel nut practices in Micronesia. In addition, the study examined the social engagement of betel nut content on the image-based platform.

Results
The study findings revealed content themes referencing the betel nut or betel nut tree, betel nut preparation practices, and the unique social and cultural context surrounding betel nut activity in Guam and Micronesia. In addition, certain practices and cultural themes encouraged social engagement on Instagram.

Conclusions
The findings from this study emphasize the cultural relevance of betel nut use in Micronesia. These findings provide a basis for empirically testing hypotheses related to the etiological roles of cultural identity and pride in shaping betel nut use behavior among Micronesians, particularly youths and young adults. Such research is likely to inform the development of culturally relevant betel nut prevention and cessation programs.
Descripción del estado de salud de los tratamientos rehabilitadores en base a implantes oseointegrados
Authors: Ceballos Rafael , Muñoz Pablo , Steffens Enrique , Trucco Enrique 
Published: April 2020

Objetivo: Describir los factores asociados al estado de salud de la rehabilitación sobre implantes oseointegrados (IOI) en los pacientes atendidos en la Central Odontológica de la Primera Zona Naval de la Armada de Chile entre los años 1995 y 2015.Materiales y métodos: Estudio descriptivo de corte transversal a partir de la recolección de datos obtenidos a través de la evaluación clínica de los pacientes atendidos en la Central Odontológica de la Primera Zona Naval de la Armada de Chile, fichas clínicas y radiografías. Para la clasificación según escala de salud de los implantes se utilizaron los parámetros presentados en el Congreso Internacional de Implantología Oral de Pisa (2007). Resultados: 65 IOI, correspondientes a 30 pacientes, fueron analizados. 63 se encontraron en boca, con un tiempo promedio de 6.9 años de permanencia. El 50,76% se consideró exitoso, 38,46% con supervivencia satisfactoria, 3,07% con supervivencia comprometida y fracasados 7,69%. La asociación entre los cigarrillos diarios y el estado de salud de los IOI presentó un p valor de 0.040. Conclusiones: El fracaso de los implantes tiene un origen multifactorial. La rehabilitación en base a IOI sigue siendo una opción exitosa, predecible y segura para los pacientes.
Considerações sobre o estudo dos ameloblastomas
Authors: Barbachan João Jorge D , Rados Pantelis Varvaki , Sant'Ana Filho Manoel , Quadros Onofre Francisco 
Published: April 2020

Com a finalidade de atualizar os conhecimentos sobre o ameloblastoma, foi feita revisão da literatura e o estudo de 26 casos arquivados no Laboratório de Patologia da Facul- dade de Odontologia da Universidade Federal do Rio Grande do Sul, onde foi possível o exame histopatológico
de mais de uma área do tumor. Em 21 dos casos observamos a presença de dois ou mais tipos histológicos, sendo os mais frequentes do tipo plexiforme e folicular. São apresentados ainda, dois casos pouco frequentes quanto a localização (maxilar) e faixa etária (crianças).
STUDI PERBANDINGAN PROFIL ASAM LEMAK PADA IKAN SIDAT (Anguilla marmorata) DAN SIDAT (Anguilla bicolor) ASAL DANAU POSO KABUPATEN POSO PROVINSI SULAWESI TENGAH
Authors: Muhtiani Dewi , Ibrahim Nurlina , Jamaluddin Jamaluddin 
Published: April 2020

Sidat fish (Anguilla marmorata) and Sidat fish (Anguilla bicolor) originate from Poso lake are endemic fish of Central Sulawesi but unknown its nutritional content. This study aims to determine the type, amount of composition and differences in the composition of fatty acids in Sidat fish (Anguilla marmorata) and Sidat fish (Anguilla bicolor). Testing fatty acid composition using Gas Chromatography method by converting fat extraction result into FAME (Fatty Acid Methyl Ester) form. The results showed that the amount of fatty acid content was not significant between the two samples. The fatty acid compositions found in Sidat (Anguilla marmorata) A, B and C fish include saturated fatty acids (2.62%), (2.81%), and (2.6%), monounsaturated fatty acids (1.98% ), (1.99%), and (10.1%), compound unsaturated fatty acids (0.635%), (0.812%), and (2.56%), mean while Sidat fish (Anguilla bicolor) A, B and C include saturated fatty acids (2.7%), (2.86%), and (12.704%), monounsaturated fatty acids (1.99%), (2.52%), (10.147%), and fatty acids unsaturated compounds (0.693%), (0.86%), and (2.615%).
Post-gel and Total Shrinkage Stress of Conventional and Bulk-fill Resin Composites in Endodontically-treated Molars
Authors: da Silva Pereira RA , de Bragança GF , Vilela ABF , de Deus RA , Miranda RR , Veríssimo C , Soares CJ 
Published: April 2020

Clinical Relevance
The clinician should consider the polymerization shrinkage stress when selecting a composite resin for posterior restorations. The use of post-gel shrinkage values should guide the selection of a composite resin for posterior teeth.

SUMMARY
Objectives: The objective of this study was to evaluate the effect of the method used for calculation of polymerization shrinkage, total or post-gel, on the shrinkage stress of conventional and bulk-fill composite resins for restoring endodontically treated teeth using finite element analysis.
Methods and Materials: Four composite resins were tested for post-gel shrinkage (P-Shr) by the strain-gauge test and total shrinkage (TShr) using an optical method (n=10). Two conventional composite resins, Filtek Z350 XT (3M-ESPE; Z350) and TPH3 Spectrum (Dents-ply; TPH3) and two bulk-fill composite resins. Filtek Bulk-Fill Posterior (3M-ESPE; POST) SureFil SDR flow (Dentsply; SDR) were tested. Elastic modulus (E), diametral tensile strength (DTS), and compressive strength (CS) were also determined (n=10). The residual shrinkage stress was evaluated by finite element analysis with four restorative techniques: incremental with Z350 and TPH3; SDR/TPH3 (two bulk increments of 4 mm and two occlusal increments); and two bulk increments of 5 mm for POST. Data for P-Shr, T-Shr, E, DTS, and CS were analyzed by analysis of variance and Tukey’s test (α=0.05), and residual shrinkage was analyzed quantitatively and qualitatively by the modified von Mises criteria.
Results: SDR had the lowest CS values, POST and TPH3 had similar and intermediate values, and Z350 had the highest CS. TPH3 and Z350 had similar DTS values and values higher than SDR. Z350 and POST had higher P-Shr, and SDR had lower T-Shr. T-Shr resulted in higher shrinkage stress than P-Shr values. SDR/TPH3 resulted in higher shrinkage stress when using T-Shr and lower values when using the P-Shr value.
Conclusion: T-Shr resulted in higher stress in the enamel and in root dentin close to the pulp chamber than P-Shr values. The selection of the T-Shr or P-Shr changed the ranking of the shrinkage stress of the tested composite resin.
IMPACT OF VARIOUS 2, 4-D CONCENTRATIONS AND DIFFERENT VITAMIN MIXTURES ON in vitro CULTURE OF COCONUT (Cocos nucifera L.) BY UTILIZING SEEDLINGS SHOOT TIP
Authors: ElGioushy Sherif Fathy , Rui Liu , Fan Haikuo 
Published: April 2020

In this experiment, seedlings as sources for shoot tips was assembled from the coconut research institute (CRI) of Chinese Academy of tropical agricultural sciences germplasm, Wenchang, Hainan, China. The shoot tips were cultured on Y3 medium to study the impact of ten concentrations of 2, 4-D and three vitamin mixtures on survival, death and development % on in vitro culture establishment stage of coconut (Cocos nucifera L.). The obtained results revealed that all 2,4-D concentrations 4,7, 75, 100, 120 and 140 mg/L + any vitamin mixture did not give any development and high concentrations of 2, 4-D increased the death %. In any case, it can be concluded that the rate of differences in survival, death and development percentages exhibited by 2, 4-D concentrations was more pronounced than the analogous ones resulted by vitamin mixtures. At any rate, utilizing of (2, 4-D at concentration 25 mg/L+ vitamin mixture 1 or 2) exhibited the greatest values of survival percentage and reduced death percentage. Just as, increased the percentages of development in in vitro culture establishment stage of coconut (Cocos nucifera L.) through seedlings shoot tip.
Gamma-hydroxybutyrate abuse: pharmacology and poisoning and withdrawal management
Authors: Marinelli Enrico , Beck Renata , Malvasi Antonio , Faro Alfredo Fabrizio Lo , Zaami Simona 
Published: April 2020

Abstract
Gamma-hydroxybutyrate (GHB) is a central nervous system depressant primarily used as a recreational drug of abuse, but also for the treatment of narcolepsy with cataplexy in adult patients and as an adjuvant for control of alcohol withdrawal syndrome. The main aim of this review is to summarise updated knowledge about GHB pharmacokinetics and pharmacodynamics, acute poisoning, and clinical features of GHB withdrawal syndrome, its diagnosis and medical treatment. The most common clinical signs and symptoms of acute poisoning include sleepiness to deep coma, bradycardia, hypotension, and respiratory failure. Therapy is essentially supportive and based on continuous monitoring of vital signs. GHB withdrawal syndrome shares patterns with other withdrawal syndromes such as alcohol withdrawal and is sometimes difficult to distinguish, especially if toxicological tests are GHB-negative or cannot be performed. There are no official detoxification protocols for GHB withdrawal syndrome, but its therapy is based on benzodiazepine. When benzodiazepine alone is not effective, it can be combined with barbiturates or antipsychotics. Information about abuse and distribution of GHB and its precursors/analogues among the general population is still limited. Their prompt identification is therefore crucial in conventional and non-conventional biological matrices, the latter in particular, to clarify all the issues around this complex molecule.
Analytical and approximate solutions of Fractional Partial Differential-Algebraic Equations
Authors: Günerhan Hatıra , Çelik Ercan 
Published: April 2020

Abstract
In this paper, we have extended the Fractional Differential Transform method for the numerical solution of the system of fractional partial differential-algebraic equations. The system of partial differential-algebraic equations of fractional order is solved by the Fractional Differential Transform method. The results exhibit that the proposed method is very effective.
A New Approach to (3+1) Dimensional Boiti–Leon–Manna–Pempinelli Equation
Authors: Yel Gülnur , Aktürk Tolga 
Published: April 2020

Abstract
In this article, some new travelling wave solutions of the (3+1) dimensional Boiti–Leon–Manna–Pempinelli (BLMP) equation are obtained using the modified exponential function method. When the solution functions obtained are examined, it is seen that functions with periodic functions are obtained. Two and three dimensional graphs of the travelling wave solutions of the BLMP equation are drawn by selecting the appropriate parameters
Estimation of Genetic Components of Cocoa Populations (Theobroma cacao L.) in Seedling Phase
Authors: Agung Wahyu Susilo  , Sobir  , Desta Wirnas  , Wuriandani Adinda 
Published: April 2020

Seedling is often used as planting material and rootstock for clonal propagation in cocoa. Seedling as cocoa planting material came form superior parents or crosses of superior parents. The research aimed to estimate the genetic components of cocoa morphological characters using the North Carolina II mating design. Three female parent genotypes, namely KW 516, Sulawesi 3, and TSH 858, were crossed with two male parent genotypes, namely ICCRI 09 and Scavina 6. Observed variables consisted of plant height, stem diameter, number of leaves, leaf area, root length, root volume, shoot fresh and dry weight, root fresh and dry weight, root:shoot ratio at 16 weeks after showing. General combining ability (GCA) value showed Sulawesi 3 as the best female parent, and Scavina 6 as the best male parent. Specific combining ability (SCA) values showed TSH 858 x Scavina 6, KW 516 x ICCRI 09, and Sulawesi 3 x ICCRI 09 as the best crosses. Sulawesi 3 x ICCRI 09 seedlings had good vigor and met the criteria for transplanting. Cocoa morphological characters were affected by dominant gene action except for root volume.
Keywords: seedling, North Carolina II, general combining ability, specific combining ability
Local Anesthetic Injection Resolves Movement Pain, Motor Dysfunction, and Pain Catastrophizing in Individuals With Chronic Achilles Tendinopathy: A Nonrandomized Clinical Trial
Authors: Chimenti Ruth L. , Hall Mederic M. , Dilger Connor P. , Merriwether Ericka N. , Wilken Jason M. , Sluka Kathleen A. 
Published: April 2020

Objectives Peripherally directed treatments (targeted exercise, surgery) can reduce, but not fully eliminate, pain for up to 40% of patients with Achilles tendinopathy. The objectives of the present study were (1) to identify indicators of altered central processing in participants with Achilles tendinopathy compared to controls, and (2) to determine which indicators of altered central processing would persist after a local anesthetic injection in patients with Achilles tendinopathy. Design Mechanistic clinical trial. Methods Forty-six adults (23 with chronic Achilles tendinopathy, 23 matched controls) repeated (1) a movement-evoked pain rating, (2) motor performance assessment, (3) pain psychology questionnaires, and (4) quantitative sensory testing. Participants with Achilles tendinopathy received a local anesthetic injection before repeat testing and controls did not. Mixed-effects analyses of variance examined the effects of group, time, and group by time. Results The Achilles tendinopathy group had movement-evoked pain, motor dysfunction, and higher pain psychological factors (pain catastrophizing, kinesiophobia) compared to controls (P<.05). The Achilles tendinopathy group did not have indicators of nociplastic pain with quantitative sensory testing (P>.05). In those with Achilles tendinopathy, local anesthetic injection eliminated pain and normalized the observed deficits in heel-raise performance and pain catastrophizing (group-by-time effect, P<.01), but not in kinesiophobia (P = .45). Injection did not affect measures of nociplastic pain (P>.05). Conclusion People with Achilles tendinopathy had elevated pain psychological factors and motor dysfunction but no signs of nociplastic pain with quantitative sensory testing. Removal of nociceptive input normalized movement-evoked pain and some indicators of altered central processing (motor dysfunction, pain catastrophizing), but not kinesiophobia. J Orthop Sports Phys Ther 2020;50(6):334–343. Epub 29 Apr 2020. doi:10.2519/jospt.2020.9242
Conformations and Three-Dimensional Structures of Selected SARS-CoV-2 Drug Candidates
Authors: Kirschner Karl , Razzaq Javed , Berrendorf Rudolf , Heiden Wolfgang 
Published: April 2020

Quantum mechanical theories are used to search and optimize the conformations of proposed small molecule candidates for treatment of SARS-CoV-2. These candidate compounds are taken from what is reported in the news and in other pre-peer-reviewed literature (e.g. ChemRxiv, bioRxiv). The goal herein is to provide predicted structures and relative conformational stabilities for selected drugs and ligands, in the hopes that other research groups can make use of them for developing a treatment. The following six compounds are investigated: chloroquine, hydroxychloroquine, eriodictyol, silmitasertib and valproic acid.Initial exploration for conformations are performed at the HF/6-31G(d)//HF/6-31G(d) theory level, which are then further optimized at more rigorous theory levels (e.g. B97-D3BJ/cc-pVTZ//B97-D3BJ/cc-pVTZ). The resulting structures are made available via GitHub.