bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative efficacy and cost–utility of combined cataract and minimally invasive glaucoma surgery in primary open-angle glaucoma
Authors: Bartelt-Hofer Jose , Flessa Steffen 
Published: March 2020

AbstractPurposeTo assess the comparative efficacy and the long-term cost–utility of alternative minimally invasive glaucoma surgeries (MIGSs) when combined with cataract surgery in patients with primary open-angle glaucoma (POAG).MethodsTreatment effects, as measured by the 1-year reduction in intraocular pressure (IOP), were estimated with an adjusted indirect treatment comparison. Evidence from randomized clinical trials was identified for four different MIGS methods. A disease-transition model was developed by capturing clinically relevant POAG stages and the expected natural disease evolution. Outcomes of the disease-transition model were the comparative utility [quality-adjusted life years (QALYs)], cost and cost–utility of included strategies in a lifetime horizon.ResultsEstimated 1-year IOP reductions were: cataract surgery − 2.05 mmHg (95% CI − 3.38; − 0.72), one trabecular micro-bypass stent − 3.15 mmHg (95% CI − 5.66; − 0.64), two trabecular micro-bypass stents − 4.85 mmHg (95% CI − 7.71; − 1.99) and intracanalicular scaffold − 2.25 mmHg (95% CI − 4.87; 0.37). Discounted outcomes from the disease-transition model appraised the strategy of two trabecular micro-bypass stents with cataract surgery in the moderate POAG stage as the one providing the greatest added value, with 10,955€ per additional QALY. Improved outcomes were seen when assessing MIGS in the moderate POAG stage.ConclusionsWhen indirectly comparing alternative MIGS methods combined with cataract surgery, the option of two trabecular micro-bypass stents showed both a superior efficacy and long-term cost–utility from a German perspective. Moreover, outcomes of the disease-transition model suggest POAG patients to beneficiate the most from an earlier intervention in the moderate stage contrary to waiting until an advanced disease is present.
MAS NMR detection of hydrogen bonds for protein secondary structure characterization
Authors: Friedrich Daniel , Perodeau Jacqueline , Nieuwkoop Andrew J. , Oschkinat Hartmut 
Published: March 2020

AbstractHydrogen bonds are essential for protein structure and function, making experimental access to long-range interactions between amide protons and heteroatoms invaluable. Here we show that measuring distance restraints involving backbone hydrogen atoms and carbonyl- or α-carbons enables the identification of secondary structure elements based on hydrogen bonds, provides long-range contacts and validates spectral assignments. To this end, we apply specifically tailored, proton-detected 3D (H)NCOH and (H)NCAH experiments under fast magic angle spinning (MAS) conditions to microcrystalline samples of SH3 and GB1. We observe through-space, semi-quantitative correlations between protein backbone carbon atoms and multiple amide protons, enabling us to determine hydrogen bonding patterns and thus to identify β-sheet topologies and α-helices in proteins. Our approach shows the value of fast MAS and suggests new routes in probing both secondary structure and the role of functionally-relevant protons in all targets of solid-state MAS NMR.
On Temporal Scale Separation in Coupled Data Assimilation with the Ensemble Kalman Filter
Authors: Tondeur Maxime , Carrassi Alberto , Vannitsem Stephane , Bocquet Marc 
Published: March 2020

AbstractData assimilation for systems possessing many scales of motions is a substantial methodological and technological challenge. Systems with these features are found in many areas of computational physics and are becoming common thanks to increased computational power allowing to resolve finer scales and to couple together several sub-components. Coupled data assimilation (CDA) distinctively appears as a main concern in numerical weather and climate prediction with major efforts put forward by meteo services worldwide. The core issue is the scale separation acting as a barrier that hampers the propagation of the information across model components (e.g. ocean and atmosphere). We provide a brief survey of CDA, and then focus on CDA using the ensemble Kalman filter (EnKF), a widely used Monte Carlo Gaussian method. Our goal is to elucidate the mechanisms behind information propagation across model components. We consider first a coupled system of equations with temporal scale difference, and deduce that: (i) cross components effects are strong from the slow to the fast scale, but, (ii) intra-component effects are much stronger in the fast scale. While observing the slow scale is desirable and benefits the fast, the latter must be observed with high frequency otherwise the error will grow up to affect the slow scale. Numerical experiments are performed using the atmosphere-ocean model, MAOOAM. Six configurations are considered, differing for the strength of the atmosphere-ocean coupling and/or the number of model modes. The performance of the EnKF depends on the model configuration, i.e. on its dynamical features. A comprehensive dynamical characterisation of the model configurations is provided by examining the Lyapunov spectrum, Kolmogorov entropy and Kaplan–Yorke attractor dimension. We also compute the covariant Lyapunov vectors and use them to explain how model instabilities act on different model’s modes according to the coupling strength. The experiments confirm the importance of observing the fast scale, but show also that, despite its slow temporal scale, frequent observations in the ocean are beneficial. The relation between the ensemble size, N, and the unstable subspace dimension, $$n_0$$

n
0

, has been studied. Results largely ratify what known for uncoupled system: the condition $$N\ge n_0$$

N
≥

n
0

is necessary for the EnKF to work satisfactorily. Nevertheless the quasi-degeneracy of the Lyapunov spectrum of MAOOAM, with many near-zero exponents, is potentially the cause of the smooth gradual reduction of the analysis error observed for some model configurations, even when $$N>n_0$$

N
>

n
0

. Future prospects for the EnKF in the context of coupled ocean-atmosphere systems are finally discussed.
Surgical stress detection in human blood plasma by DSC
Authors: Ferencz Andrea , Lőrinczy Dénes 
Published: March 2020

AbstractIt is a well-known fact that the extension of the surgical intervention influences both the success and time of the patient’s recovery, the degree of the blood loss, i.e., overall the patients’ surgical burden. Disease itself determines extent of surgical procedure (minor, intermediate or major surgery), which affects the risk and frequency of complications. Previous works have contributed to the validation of differential scanning calorimetry (DSC) as a potential non-invasive tool for diagnosing and monitoring several illnesses. Hence, the main goal of this study was to measure the effect of each surgical intervention on its own to blood plasma composition. Peripheral venous blood samples were collected from patients who underwent minor (n = 8), intermediate (n = 9) and major surgical interventions (n = 7). According our DSC data of blood plasma components, from the thermodynamic parameters, namely from the thermal transitions (Tm1–Tm8) to calorimetric enthalpy (ΔHcal) in proportion corresponded to the size of surgical interventions (duration of operation time, length of incision, surgical intraoperative stress, blood loss, etc.). This examination has shown that intraoperative stress during any surgical intervention affects the composition of plasma proteins, which should be always considered in the evaluation of DSC results in any surgical study.
Using isothermal calorimetry and FT-Raman spectroscopy for step-by-step monitoring of maize seed germination: case study
Authors: Stawoska Iwona , Staszak Aleksandra M. , Ciereszko Iwona , Oliwa Jakub , Skoczowski Andrzej 
Published: March 2020

AbstractThermoanalytical methods are widely used to study seed germination processes. Our research aimed to use them in order to monitor the germination of maize seeds. To this end, we employed—for the first time—the isothermal calorimetric method with full oxygen access. Dry seeds were placed in ampoules with threaded caps, filled with distilled water. Heat flow was recorded in microwatts at 20 °C for 72 h in order to determine changes in thermal power associated with germination. In parallel with these measurements, in the same time regime, we measured FT-Raman spectra, which allowed us to analyze how endosperm and embryo changed their chemical compositions during imbibition and germination. Spectra obtained for endosperm reflected chemical changes resulting from catabolic processes. We also analyzed variations in the secondary structure of proteins in the embryo accompanying germination. Decomposition of amide I bands proved that during germination and protein hydrolysis, the content of helical and β-sheet structures decreased. Furthermore, in the embryos of dry seeds, S-S linkages were in both gauche–gauche-trans and trans-gauche-trans conformations, but after imbibition, only gauche–gauche-trans conformation can be identified.
Application of Oil-in-Water Nanoemulsion Carrying Size-Defined Gold Nanoparticles Synthesized by Non-thermal Plasma for the Human Breast Cancer Cell Lines Migration and Apoptosis
Authors: Dzimitrowicz Anna , Bielawska-Pohl Aleksandra , Pohl Pawel , Jermakowicz-Bartkowiak Dorota , Jamroz Piotr , Malik-Gajewska Magdalena , Klimczak Aleksandra , Cyganowski Piotr 
Published: March 2020

AbstractIn this work, the gold nanoparticles (AuNPs) were synthesized using pulse-modulated radio-frequency atmospheric pressure glow discharge (pm-rf-APGD). By tailoring selected operating parameters of the pm-rf-APGD reaction-discharge system, the experimental conditions for the synthesis of raw-AuNPs with controlled optical and structural properties were found. The colloidal suspension of the size-controlled raw-AuNPs was mixed with an aqueous solution of gelatine and turmeric oil to produce an oil-in-water (O/W) nanoemulsion. AuNPs loaded into the nanoemulsion were characterized using ultraviolet–visible absorption spectrophotometry, dynamic light scattering, scanning electron microscopy supported by energy dispersive X-ray spectroscopy, and transmission electron microscopy equipped with selected area X-ray diffraction. Additionally, attenuated total reflectance Fourier-transform infrared spectroscopy was used to confirm the efficient functionalization of the AuNPs by nanoemulsion component. It was revealed that AuNPs were mostly spherical with an average size of 4.6 ± 1.0 nm and a face-centered cubic crystal system. The developed O/W nanoemulsion carrying AuNPs was applied towards the human breast cancer cell lines MCF7 and MDA-MB-231. It was found that it exhibited the cytotoxicity towards the breast cancer cells while were non-cytotoxic towards the non-tumour breast cells MCF10A. Moreover, it also inhibited the migration of the invasive cancer breast cells (line MDA-MB-231) and hence, could prevent the breast cancer metastasis.
Consensus statement from 2nd International Conference on Controversies in Vitamin D
Authors: Giustina A. , Adler R. A. , Binkley N. , Bollerslev J. , Bouillon R. , Dawson-Hughes B. , Ebeling P. R. , Feldman D. , Formenti A. M. , Lazaretti-Castro M. , Marcocci C. , Rizzoli R. , Sempos C. T. , Bilezikian J. P. 
Published: March 2020

AbstractThe 2ndInternational Conference on Controversies in Vitamin D was held in Monteriggioni (Siena), Italy, September 11-14, 2018. The aim of this meeting was to address ongoing controversies and timely topics in vitamin D research, to review available data related to these topics and controversies, to promote discussion to help resolve lingering issues and ultimately to suggest a research agenda to clarify areas of uncertainty. Several issues from the first conference, held in 2017, were revisited, such as assays used to determine serum 25-hydroxyvitamin D [25(OH)D] concentration, which remains a critical and controversial issue for defining vitamin D status. Definitions of vitamin D nutritional status (i.e. sufficiency, insufficiency and deficiency) were also revisited. New areas were reviewed, including vitamin D threshold values and how they should be defined in the context of specific diseases, sources of vitamin D and risk factors associated with vitamin D deficiency. Non-skeletal aspects related to vitamin D were also discussed, including the reproductive system, neurology, chronic kidney disease and falls. The therapeutic role of vitamin D and findings from recent clinical trials were also addressed. The topics were considered by 3 focus groups and divided into three main areas: 1) “Laboratory”: assays and threshold values to define vitamin D status; 2) “Clinical”: sources of vitamin D and risk factors and role of vitamin D in non-skeletal disease and 3) “Therapeutics”: controversial issues on observational studies and recent randomized controlled trials. In this report, we present a summary of our findings.
Perspectives on Sexuality Among Patients with Hypopituitarism: Broadening the Medical Focus on Sexual Function to Include Sexual Wellbeing
Authors: Dellenborg Lisen , Persson Jenny Tiberg , Jakobsson Ung Eva , Johannsson Gudmundur , Olofsson Ann-Charlotte , Björkman Ida 
Published: March 2020

AbstractHypopituitarism means a partial or complete inability to produce pituitary hormones, including those regulating gonadal function. The condition therefore leads to hormone deficiencies that may affect sexuality in various ways. This study aimed to explore patients’ own experiences of hypopituitarism in relation to sexuality, and it is based on interviews with 19 men and women. A qualitative methodology inspired by Gadamer’s philosophical hermeneutics was used. Analysis revealed that current healthcare practices, which focus primarily on sexual functioning, fail to address patients’ existential concerns about loneliness, loving relationships and selfhood. Another important finding was that women felt that their sexual functioning and wellbeing tended to go unnoticed, while men said that healthcare professionals focused mainly on erectile function rather than problems with sexual wellbeing. Cultural and gender norms were apparent in these healthcare interactions, and proactive efforts to improve awareness is required in order to improve the quality of care provided to these patients. Healthcare professionals need time, space and support for reflection so that they may enhance their knowledge about the complexity of sexuality and discuss the results of research into hormone replacement in men and women. They also need support to develop critical awareness of how gendered norms about sexuality may negatively affect the care provided to persons with hypopituitarism.
The multiple relation theory and Schiffer’s puzzle
Authors: Rinner Stefan 
Published: March 2020

AbstractFollowing Russell, philosophers like Moltmann, Jubien, Boër, and Newman analyse ‘John believes that Mary is French’ as ‘R (John, the property of being French, Mary)’, instead of analysing it as ‘R (John, that Mary is French)’. Thus, for these philosophers, instead of relations holding between agents and truth-bearing entities (propositions), propositional attitude verbs, like ‘belief’, express relations holding between agents and the properties and objects our thoughts and speech acts are about. This is also known as the Multiple Relation Theory. In this paper, I will discuss the Multiple Relation Theory primarily in connection with a problem known as Schiffer’s puzzle. Schiffer first presented the puzzle to argue against the so called direct-reference theory of belief reports advocated, among others, by Salmon and Braun. I will argue that, unlike the direct-reference theory of belief reports, the Multiple Relation Theory does not provide a solution to Schiffer’s puzzle. In this connection, I will also discuss a slight modification of the Multiple Relation Theory according to which the ways the properties and objects our thoughts and speech acts are about are presented to us are part of the truth-conditions of sentences like ‘John believes that Mary is French’. We will see that prima facie such a contextualist version of the Multiple Relation Theory provides a solution to Schiffer’s puzzle. However, concluding, I will argue with new Schiffer cases that, ultimately, also a contextualist version of the Multiple Relation Theory cannot explain all instances of Schiffer’s puzzle. This will undermine the Multiple Relation Theory in general.
History of Economic Thought as an Analytic Tool: why Past Intellectual Ideas Must Be Acknowledged as Lighthouses for the Future
Authors: Bögenhold Dieter 
Published: March 2020

AbstractContemporaries tend to question certain belief systems including academic systems of knowledge. Paradigms evolve to become a subject of inquiry. The need to acknowledge history of economic thought as a neglected but important domain of economic inquiry as an important discussion topic. During recent decades, history of economic thought has largely been abolished and has disappeared from many contemporary teaching curricula in economics. The article argues that our academic understanding of economics is incomplete if we do not respect history and understand the social embeddedness of economic institutions and social behaviour. Of course, one must distinguish between history of intellectual ideas and economic history. Both items have to be discussed separately when assessing methodological appropriateness and benefits. The argumentation is based on the work of Joseph A. Schumpeter who dealt in detail with the question why and how to deal with historiography as a tool of proper economics in his substantial introduction to the 1945 bookHistory of Economic Analysis.
Enzymatic studies on aromatic prenyltransferases
Authors: Mori Takahiro 
Published: March 2020

AbstractAromatic prenyltransferases (PTases), including ABBA-type and dimethylallyl tryptophan synthase (DMATS)-type enzymes from bacteria and fungi, play important role for diversification of the natural products and improvement of the biological activities. For a decade, the characterization of enzymes and enzymatic synthesis of prenylated compounds by using ABBA-type and DMATS-type PTases have been demonstrated. Here, I introduce several examples of the studies on chemoenzymatic synthesis of unnatural prenylated compounds and the enzyme engineering of ABBA-type and DMATS-type PTases.
Forbidden Revolutions: David Martin’s Encounter with Pentecostalism
Authors: Maxwell David 
Published: March 2020

AbstractThis article illuminates how David Martin’s engagement with Pentecostalism represented a significant turning point in his career in both personal and academic terms. It allowed him to come to terms with his own Methodist ‘revivalist childhood’ and to generate new insights into his pre-existing concerns: insights into the sociological method, the relation of religion to politics, the modernity of religion, and the secularisation thesis. In particular, it brought new energy to his continuing mission to persuade his own sociological profession, along with a liberal-minded intelligentsia, to see the social and political significance of contemporary religious expressions. David wrote with profundity and poignancy about the mentalities and aspirations of ordinary Pentecostal adherents, aware that communities of the poor across the globe aspired to an all-around ‘betterment’ from on high. His research and mentoring of young scholars inspired those pioneering the anthropology of Christianity in the early 2000s and prompted interventions in debates on the nature of World Christianity.
The Parasitic Nature of Social AI: Sharing Minds with the Mindless
Authors: Sætra Henrik Skaug 
Published: March 2020

AbstractCan artificial intelligence (AI) develop the potential to be ourpartner, and will we be as sensitive to its social signals as we are to those of human beings? I examine both of these questions and how cultural psychology might add such questions to its research agenda. There are three areas in which I believe there is a need for both a better understanding and added perspective. First, I will present some important concepts and ideas from the world of AI that might be beneficial for pursuing research topics focused on AI within the cultural psychology research agenda. Second, there are some very interesting questions that must be answered with respect to central notions in cultural psychology as these are tested through human interactions with AI. Third, I claim that social robots areparasiticto deeply ingrained human social behaviour, in the sense that they exploit and feed upon processes and mechanisms that evolved for purposes that were originally completely alien to human-computer interactions.
New Therapeutic Strategy and Innovative Lubricating Ophthalmic Solution in Minimizing Dry Eye Disease Associated with Cataract Surgery: A Randomized, Prospective Study
Authors: Fogagnolo Paolo , Favuzza Eleonora , Marchina Daniele , Cennamo Michela , Vignapiano Roberto , Quisisana Chiara , Rossetti Luca , Mencucci Rita 
Published: March 2020

Abstract
Introduction
To evaluate the effects of a new lubricating, antioxidant solution (VisuEvo®) on dry eye disease (DED) in patients undergoing cataract surgery.

Methods
Patients requiring cataract surgery with either healthy ocular surface or mild DED (tear break-up time, TBUT > 7, Schirmer I test > 15 mm/5 min) were enrolled in this multicenter, open-label, randomized, prospective study. Scheduled visits were 2 weeks before surgery (screening), day of surgery (V0), week 1 (V1), and 2 (V2) after surgery. VisuEvo® was self-administered three times daily for the whole study duration (group A); the control group (group B) had no tear substitute administration. The primary endpoint was the change in TBUT over time; the secondary endpoints were changes in Ocular Surface Disease Index (OSDI), ocular surface staining, the Schirmer I test, and osmometry.

Results
A total of 45 patients were included (group A, 23; group B, 22; age 74 ± 8 years). At the screening, TBUT was similar between the groups (group A, 8.5 ± 1.8 s; group B, 7.8 ± 0.7, p = 0.11). At the scheduled visits, TBUT increase vs screening visit was significantly higher in group A: +1.2 s at V0, +1.4 s at V1, and +1.9 s at V2 (p < 0.01). Also, OSDI was significantly lower in group A at V0, V1, and V2 (p < 0.027). After surgery, corneal staining was absent in 65–78% of group A compared with 54–59% in group B. The two groups did not show any significant differences of osmometry and the Schirmer I test.

Conclusions
The ocular surface was more protected and quickly restored from surgery when VisuEvo® was used from 2 weeks preoperatively to 2 weeks postoperatively.

Trial registration
ClinicalTrials.gov identifier, NCT03833908