bluuebunny/crossref_metadata_2025_split huggingface dataset:
The coupling of translational control and stress responses
Authors: Houston Ryan , Sekine Shiori , Sekine Yusuke 
Published: May 2020

Abstract
The translation of messenger RNA (mRNA) into protein is a multistep process by which genetic information transcribed into an mRNA is decoded to produce a specific polypeptide chain of amino acids. Ribosomes play a central role in translation by coordinately working with various translation regulatory factors and aminoacyl-transfer RNAs. Various stresses attenuate the ribosomal synthesis in the nucleolus as well as the translation rate in the cytosol. To efficiently reallocate cellular energy and resources, mammalian cells are endowed with mechanisms that directly link the suppression of translation-related processes to the activation of stress adaptation programmes. This review focuses on the integrated stress response (ISR) and the nucleolar stress response (NSR) both of which are activated by various stressors and selectively upregulate stress-responsive transcription factors. Emerging findings have delineated the detailed molecular mechanisms of the ISR and NSR and expanded their physiological and pathological significances.
Sovereign Debt Restructurings: Delays in Renegotiations and Risk Averse Creditors
Authors: Asonuma Tamon , Joo Hyungseok 
Published: May 2020

Abstract
Foreign creditors’ business cycles influence both the process and the outcome of sovereign debt restructurings. We compile two datasets on creditor committees and chairs and on creditor business and financial cycles at the restructurings. We find that when creditors experience high GDP growth, restructurings are delayed and settled with smaller haircuts. To rationalize these stylized facts, we develop a theoretical model of sovereign debt with multiround renegotiations between a risk averse sovereign debtor and a risk averse creditor. The quantitative analysis of the model shows that high creditor income results in both longer delays in renegotiations and smaller haircuts. Our theoretical predictions are supported by data.
Skeletal muscle measurements predict surgical wound complications but not overall survival in patients with soft tissue sarcoma
Authors: Hirai Toshihide , Kobayashi Hiroshi , Okuma Tomotake , Ishibashi Yuki , Ikegami Masachika , Ohki Takahiro , Shinoda Yusuke , Okajima Koichi , Zhang Liuzhe , Akiyama Toru , Goto Takahiro , Tanaka Sakae 
Published: May 2020

Abstract

Background
It is unknown whether sarcopenia influences treatment outcome in patients with soft tissue sarcoma. Herein, we aimed to elucidate the impact of sarcopenia on sarcoma treatment.

Methods
A total of 163 soft tissue sarcoma patients were included. Skeletal muscle measures were calculated using computed tomography images. Skeletal muscle area (SMA) and density (SMD) at the L3 level were extracted, and SMA was normalized by height as skeletal muscle index (SMI). The skeletal muscle gauge (SMG) was calculated by multiplying SMD × SMI. The relationship of skeletal muscle measures and clinical factors to wound complications and prognosis was evaluated, and classification and regression tree (CART) analysis was used to develop classification models for risk groups of surgical wound complications.

Results
Thirty-three patients developed wound complications. In univariate analysis, age (P = 0.0022), tumour location of adductor compartment of the thigh (P = 0.0019), operating time (P = 0.010), blood loss (P = 0.030), SMD (P = 0.0004) and SMG (P = 0.0001) were significantly correlated with complications. In multivariate analysis, lower SMG was an independent risk factor (P = 0.031, OR = 3.27). CART analysis classified three risk groups of surgical wound complications by SMG, age, tumour location and operating time, and area under the receiver operating characteristic curve (AUROCC) was 0.75. SMG was not associated with prognosis in univariate analysis (P = 0.15).

Conclusions
The SMG does not affect overall survival but predicts surgical wound complications.
Distribution and conservation status of the endangered Montagne d’Ambre fork-marked lemur (Phaner electromontis)
Authors: Hending Daniel , Sgarlata Gabriele M , Le Pors Barbara , Rasolondraibe Emmanuel , Jan Fabien , Rakotonanahary Ando N , Ralantoharijaona Tantely N , Debulois Stéphane , Andrianiaina Angelo , Cotton Sam , Rasoloharijaona Solofonirina , Zaonarivelo John R , Andriaholinirina Nicole V , Chikhi Lounès , Salmona Jordi 
Published: May 2020

Abstract
The geographic distribution of a species can provide insights into its population size, ecology, evolution, and how it responded to past (and may respond to future) environmental change. Improving our knowledge of the distribution of threatened species thus is a high priority in assessing their conservation status. However, there are few data available for many recently described yet understudied and potentially threatened primate taxa, making their conservation difficult. Here, we investigated the distribution of the Montagne d’Ambre fork-marked lemur, Phaner electromontis, a threatened nocturnal primate endemic to northern Madagascar and classified as Endangered by the IUCN. Because fork-marked lemurs are highly vocal, we used acoustic surveys to assess the species’ presence-absence and relative population density within 66 distinct forest survey sites in northern Madagascar. Further, we compared data among five forest types within the study area and investigated the relationship between relative population density and climate variables. We report the presence of P. electromontis in 22 study sites; several of these populations were unknown previously. Although we found P. electromontis most frequently in dry-transitional forests, our results suggest that geography (spatial autocorrelation) rather than environmental variables explains the species’ distribution. We hypothesize that environmental unpredictability and gummivory, combined with the presence of several distinct Phaner species in the studied area, could explain the observed distribution.
Arthropod Assault: A Case Report of Brown Recluse Envenomation in a Training Environment
Authors: Merrill Daniel R , Long Brit 
Published: May 2020

Abstract
Spider bites are a common emergency department complaint, accounting for ~21% of noncanine bites, injuries, and stings. Military service members, more so than most civilian personnel, are exposed to conditions that place them at increased risk for envenomation, stings, and bites. We present the case of an active duty service member working in a relatively austere environment who presented to a level 1 trauma center with a lesion consistent with a bite from a brown recluse spider, or Loxosceles reclusa.
H0LiCOW – XI. A weak lensing measurement of the external convergence in the field of the lensed quasar B1608+656 using HST and Subaru deep imaging
Authors: Tihhonova O , Courbin F , Harvey D , Hilbert S , Peel A , Rusu C E , Fassnacht C D , Bonvin V , Marshall P J , Meylan G , Sluse D , Suyu S H , Treu T , Wong K C 
Published: May 2020

ABSTRACT
We investigate the environment and line of sight (LoS) of the H0LiCOW (H0 Lenses in COSMOGRAIL’s Wellspring) lens B1608+656 using Subaru Suprime-Cam and the Hubble Space Telescope (HST) to perform a weak lensing analysis. We compare three different methods to reconstruct the mass map of the field, i.e. the standard Kaiser–Squires inversion coupled with inpainting and Gaussian or wavelet filtering, and ${\rm {\small {glimpse}}}$, a method based on sparse regularization of the shear field. We find no substantial difference between the 2D mass reconstructions, but we find that the ground-based data are less sensitive to small-scale structures than the space-based observations. Marginalizing over the results obtained with all the reconstruction techniques applied to the two available HST filters F606W and F814W, we estimate the external convergence, κext, at the position of B1608+656 is $\kappa _{\mathrm{ext}}= 0.11^{+0.06}_{-0.04}$, where the error bars correspond, respectively, to the 16th and 84th quartiles. This result is compatible with previous estimates using the number counts technique, suggesting that B1608+656 resides in an overdense LoS, but with a completely different technique. Using our mass reconstructions, we also compare the convergence at the position of several groups of galaxies in the field of B1608+656 with the mass measurements using various analytical mass profiles, and find that the weak lensing results favour truncated halo models.
Search for Zeeman-splitting of OH 6.035 GHz line in the young planetary nebula K 3-35
Authors: Hou L G , Gao X Y 
Published: May 2020

ABSTRACT
Magnetic field could play a role in the formation and early evolution of non-spherical planetary nebulae (PNe). The predominant source of information of the magnetic fields in PNe is the polarization observations of maser emission. To date, distinct and/or possible Zeeman pairs have only been reported towards four PNe by measuring the OH ground-state transitions at 1.6–1.7 GHz. With the C-band (4–8 GHz) receiving system of the Shanghai TianMa 65-m radio telescope, we aim to search for possible Zeeman pairs of the PNe towards which the OH excited-state 6.035 GHz maser lines have been detected. For the young PN K 3-35, a new emission component near VLSR = 20.5 km s−1, which is currently the strongest (Ipeak ∼ 0.3 Jy) among the four components towards K 3-35 is detected. A clear S-shaped feature corresponding to this new emission component is observed in the Stokes V spectrum. Frequency shifts are seen between the fitted left-hand circular polarization and right-hand circular polarization emission peaks for the two emission components near VLSR = 19.7 and 20.5 km s−1. If the S-shaped profile and the frequency shifts are the results of Zeeman-splitting, the line-of-sight magnetic field strengths of +2.9 ± 0.6 and +4.5 ± 0.4 mG can be inferred for these two emission components, respectively.
The shearing sheet and swing amplification revisited
Authors: Binney James 
Published: May 2020

ABSTRACT
The principal results of the classic analysis of the shearing sheet and swing amplification by Julian and Toomre (JT) are re-derived in a more accessible way and used to gain a better quantitative understanding of the dynamics of stellar discs. The axisymmetric limit of the shearing sheet is derived and used to re-derive Kalnajs’ 1965 dispersion relation and Toomre’s 1964 stability criterion for axisymmetric disturbances. Using the shearing sheet to revisit Toomre’s important 1969 paper on the group velocity implied by the Lin–Shu–Kalnajs (LSK) dispersion relation, we discover that two wavepackets emerge inside corotation: one each side of the inner Lindblad resonance. An extended form of the JT equation is used to investigate the impact of there being a deficit or surplus of stars in a narrow range of angular momenta. Swing amplification of leading waves introduced by such a groove gives rise to transient trailing spirals that extend further in radius and live longer at smaller azimuthal wavenumbers. Although the LSK dispersion relation provides useful interpretations of wavepackets, the shearing sheet highlights the limitations of the LSK approach to disc dynamics. Disturbances do not avoid an annulus around corotation, as the LSK dispersion relation implies. While disturbances of the shearing sheet have a limited life in real space, they live on much longer in velocity space, which Gaia allows us to probe extensively. c++ code is provided to facilitate applications of winding spiral waves.
Reoperation, Readmission, and Discharge Disposition for Patients With Degenerative Lumbar Pathology Treated With Either Open or Minimally Invasive Techniques: A Single-Center Retrospective Review of 1435 Cases
Authors: Altshuler Marcelle , Mueller Kyle B , MacConnell Ashley , Wirth Peter , Sandhu Faheem A , Voyadzis Jean-Marc 
Published: May 2020

Abstract

BACKGROUND
Spine surgery has been transformed by the growth of minimally invasive surgery (MIS) procedures. Previous studies agree that MIS has shorter hospitalization and faster recovery time when compared to conventional open surgery. However, the reoperation and readmission rates between the 2 techniques have yet to be well characterized.

OBJECTIVE
To evaluate the rate of subsequent revision between MIS and open techniques for degenerative lumbar pathology.

METHODS
A total of 1435 adult patients who underwent lumbar spine surgery between 2013 and 2016 were included in this retrospective analysis. The rates of need for subsequent reoperation, 30- and 90-d readmission, and discharge to rehabilitation were recorded for both MIS and traditional open techniques. Groups were divided into decompression alone and decompression with fusion.

RESULTS
The rates of subsequent reoperation following MIS and open surgery were 10.4% and 12.2%, respectively (P = .32), which were maintained when subdivided into decompression and decompression with fusion. MIS and open 30-d readmission rates were 7.9% and 7.2% (P = .67), while 90-d readmission rates were 4.3% and 3.6% (P = .57), respectively. Discharge to rehabilitation was significantly lower for patients under 60 yr of age undergoing MIS (1.64% vs 5.63%, P = .04).

CONCLUSION
The use of minimally invasive techniques for the treatment of lumbar spine pathology does not result in increased reoperation or 30- and 90-d readmission rates when compared to open approaches. Patients under the age of 60 yr undergoing MIS procedures were less likely to be discharged to rehab.
Identification of Genes Conferring Plant Salt Tolerance using GWAS: Current Success and Perspectives
Authors: Li Bo 
Published: May 2020

AbstractAn understanding of the molecular mechanisms that underlie plant salt tolerance is important for both economic and scientific interests. Genome-wide association study (GWAS) is a promising approach to pinpoint genes that confer plant salt tolerance. With the advancement of supporting technology and methodology, GWAS has enabled the discovery of genes that play central roles in regulating plant salt tolerance in the past decade. Here, I highlight recent successful GWAS work in unveiling the molecular factors underlying plant salt tolerance and discuss the concerns and opportunities in conducting such experiments. It is anticipated that GWAS will be increasingly successful in the identification of key genes that are useful for crop improvement.
New Methods in Creating Transdisciplinary Science Policy Research Agendas: The Case of Legislative Science Advice
Authors: Akerlof Karen , Allegra Alessandro , Webler Thomas , Heath Erin , Cloyd Emily T , Washbourne Carla-Leanne , Tyler Chris 
Published: May 2020

Abstract
In transdisciplinary fields such as science policy, research agendas do not evolve organically from within disciplines but instead require stakeholders to engage in active co-creation. ‘Big questions’ exercises fulfill this need but simultaneously introduce new challenges in their subjectivity and potential bias. By applying Q methodology to an exercise in developing an international collaborative research agenda for legislative science advice (LSA), we demonstrate a technique to illustrate stakeholder perspectives. While the LSA international respondents—academics, practitioners, and policymakers—demonstrated no difference in their research priorities across advisory system roles, the analysis by developing and developed nation status revealed both common interests in institutional- and systems-level research and distinct preferences. Stakeholders in developing nations prioritized the design of advisory systems, especially in low- and middle-income countries, while those in developed countries emphasized policymaker evidence use. These differences illustrate unique regional research needs that should be met through an international agenda for LSA.
0026 Strong Gene-Environment Interactions of Trank1 Gene Polymorphisms with Birth Difficulties in Kleine Levin Syndrome
Authors: Ambati A , Hillary R , Semenescu S L , Lin L , Ollila H , Farber N , Huang Y , Dauvilliers Y ,   KLS Working Group, Arnulf I , Mignot E 
Published: May 2020

Abstract

Introduction
Kleine-Levin Syndrome (KLS) is a rare disorder affecting adolescents and characterized by relapsing-remitting episodes of severe hypersomnia, cognitive impairment, and behavioral disturbances such as hyperphagia and sexual disinhibition. Pathophysiology is unknown, although imaging studies indicate decreased activity in hypothalamic/thalamic areas and in cortical areas during episodes. Familial occurrence is increased, and risk is associated with reports of complicated birth.

Methods
A worldwide Genome wide association (GWA) study was conducted in 673 KLS patients and ethnically matched 15,341 control individuals.

Results
We found a strong genome-wide significant association (OR=1.48 at rs150168018, p=8.6x10-9) with 24 single nucleotide polymorphisms (SNPs) encompassing a 35kb region located in the 5’ region of TRANK1 gene previously associated with bipolar disorder and schizophrenia. Strikingly, KLS cases with TRANK1 had statistically increased reports of difficult birth. As perinatal outcomes have dramatically improved over the last 40 years, we further stratified our sample by birth years, and found that recent cases had a significantly reduced TRANK1 association. These findings were confirmed in an independent replication cohort of 171 new patients where polygenic risk scores constructed on the discovery cohort replicated (r2=0.15; p&lt;2.7x10-22 at p=0.1 threshold) and the TRANK1 association was found to be dependent on reports of birth difficulties (OR=1.54, p=0.01 versus OR=1.12, p=0.4). Pathway analysis of the overall GWAS association revealed significant association (p=0.02) with 19 genes in a pathway modulating rhythmic behaviors.

Conclusion
Our results demonstrate links between hypersomnia, behavioral rhythmicity and bipolar disorder and indicate that a polymorphism in the TRANK1 region affect brain development in the presence of a perinatal injury, with pathophysiological consequences such as KLS, bipolar disorder and schizophrenia.

Support
NIH NIMH 1R01MH080957 to EM PHRC 070138 to IA
0029 Light Emitted from Media Devices at Night is Associated with Decline in Sperm Quality
Authors: Green A , Barak S , Shine L , Kahane A , Dagan Y , Dagan Y 
Published: May 2020

Abstract

Introduction
The last several decades have been characterized by the widespread usage of digital devices, especially smartphones. At the same time, there have been reports of male fertility decline. The aim of this study was to assess the relationship between evening exposure to the light-emitting screens of digital media devices and sperm quality.

Methods
Semen samples were obtained from 116 men adults aged between 21 and 59 (35.2 ±7.2) undergoing fertility evaluation for the following sperm variables: volume (mL), pH, sperm concentration (n/mL), motility percentage (progressive% + non-progressive motility%) and total sperm count. Exposure to the screens of electronic devices and sleep habits were obtained by means of a questionnaire.

Results
Smartphone and tablet usage in the evening and after bedtime was negatively correlated (p&lt;0.05) with sperm motility, sperm progressive motility, and sperm concentration, and positively correlated with the percentage of immotile sperm. In addition, sleep duration was positively correlated with sperm total and progressive motility and negatively correlated with semen pH (p&lt;0.05). A significant negative correlation was observed between subjective sleepiness and total and progressive motility as well as total motile sperm number (p&lt;0.05).

Conclusion
The results of this study revealed a link between evening and post-bedtime exposure to light-emitting digital media screens and sperm quality. To the best of our knowledge, this is the first study to report these types of correlations between sperm quality and exposure time to SWL emitted from digital media, especially smartphones and tablets, in the evening and after bedtime.

Support
No Support
0078 Influence of Light on Brain Activity Upon Waking From Slow Wave Sleep
Authors: Flynn-Evans E E , Hilditch C J , Chachad R , Bansal K , Wong L R , Santamaria A , Bathurst N G , Feick N H , Garcia J 
Published: May 2020

Abstract

Introduction
Waking from sleep is associated with reduced alertness due to sleep inertia. Light acutely improves alertness during sleep deprivation. In this study we assessed the influence of light on brain activity and connectivity after waking from slow wave sleep (SWS).

Methods
Twelve participants kept an actigraphy-confirmed stable sleep schedule with 8.5 hours for five nights and five hours for one night prior to an overnight laboratory visit. Participants completed two three-minute Karolinska Drowsiness Tests (KDT) before going to bed at their habitual bedtime. They were monitored continuously using high-density EEG (32-channel; Brain Products GmbH). Participants were woken twice and exposed to red light (0.01 melanopic-lux; control) or blue-enriched light (63.62 melanopic-lux) for one hour, in a randomized order, following at least five minutes of SWS. EEG artifact were removed algorithmically and the spectral composition of each electrode (i.e., fast fourier transform, FFT) and effective connectivity (i.e., partial directed coherence, PDC) between each electrode were estimated. A graphical analysis was conducted to extract features relevant to the facilitation of efficient communication between electrodes. All data were averaged within frequency bins of interest that correspond to delta (1-3Hz), theta (4-7Hz), alpha (8-12Hz), and beta (13-25Hz) bands and expressed relative to the pre-sleep baseline.

Results
Compared to the pre-sleep baseline, participants exposed to blue-enriched light experienced reduced theta and alpha activity; however, these results were not significantly different from the control. In contrast, the communication of frontal electrodes significantly increased across all frequency bands compared to the control, and this effect was most prominent in the alpha (t(11)=3.80, p=.005) and beta bands (t(11)=3.92, p=.004).

Conclusion
Exposure to blue-enriched light immediately after waking from SWS may accelerate the process of waking and help to improve alertness by facilitating communication between brain regions. Future analyses will explore the temporal persistence and granularity of the communicative properties associated with this response.

Support
Naval Postgraduate School Grant. NASA Airspace Operations and Safety Program, System-Wide Safety Project.