bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and genetic investigation of 136 Japanese patients with congenital hypothyroidism
Authors: Tanaka Tatsushi , Aoyama Kohei , Suzuki Atsushi , Saitoh Shinji , Mizuno Haruo 
Published: May 2020

Abstract

Objectives
Congenital hypothyroidism (CH) is the most common congenital endocrine disorder. Recent advances in genetic testing have revealed its causative mutations in some CH patients. However, the underlying etiology remains unknown in most patients. This study aimed to perform clinical and genetic investigation in Japanese CH patients to uncover genotype-phenotype correlations.

Methods
We enrolled 136 Japanese patients with transient or permanent CH between April 2015 and March 2017, and performed next-generation sequencing of 19 genes implicated in CH.

Results
We identified potentially pathogenic bi-allelic variants in DUOX2, TSHR, and TPO in 19, 5, and 1 patient, respectively (autosomal recessive), and a potentially pathogenic mono-allelic variant in NKX2-1 (autosomal dominant) in 1 patient. Molecular genetic diagnosis was highly suggested in 26 patients (19%) from 23 families. We also detected a potentially pathogenic mono-allelic variant in five recessive genes (DUOX2, TSHR, TG, DUOXA2, and TPO) in 31 unrelated patients (23%), although the pathogenicity of these variants remains inconclusive. Patients with bi-allelic DUOX2 variants showed a more severe clinical presentation in infancy than those with bi-allelic TSHR variants. However, this trend reversed beyond infancy. There were no statistical differences in initial thyroid stimulating hormone, free thyroxine, thyroglobulin, and levothyroxine dose as of March 2017 between patients with bi-allelic and mono-allelic DUOX2 variants.

Conclusions
The prevalence of potentially-pathogenic variants in Japanese CH patients was similar to that found by previous reports. Our study demonstrates a genotype-phenotype correlation in Japanese CH patients.
A Neo-Republican Theory of Just State Surveillance
Authors: Smith Patrick Taylor 
Published: May 2020

Abstract
This paper develops a novel, neo-republican account of just state surveillance in the information age. The goal of state surveillance should be to avoid and prevent domination, both public and private. In light of that conception of justice, the paper makes three substantive points. First, it argues that modern state surveillance based upon information technology and predicated upon a close partnership with the tech sector gives the state significant power and represents a serious potential source of domination. Second, it argues that, nonetheless, state surveillance can serve legitimate republican ends and so unilateral and private technological attempts to block it may be wrongful. Third, it argues that, despite the serious normative failings of current institutions, state surveillance can be justly regulated and made accountable through a legal liability regime that incentivizes tech company intermediaries to ally with civil society groups in order to safeguard the privacy rights of potential subjects of state surveillance.
Gestationalism and the Rights of Adolescent Mothers
Authors: Baron Teresa 
Published: May 2020

Abstract
In this paper, I explore the ways in which consideration of adolescent parents forces us to confront and question common presuppositions about parental rights. In particular, I argue that recognising the right of adolescent mothers not to be forcibly separated from their newborn children justifies rejecting the notion that parental rights are (a) all acquired in the same manner and (b) acquired as a ‘bundle’ of concomitant moral rights. I conclude that children and adolescents who conceive and give birth have some parental rights concerning their newborn children – in particular, the right not to be forcibly separated from those children – even if they do not have the ‘full complement’ of parental rights as we generally characterise these.
Improving mechanical properties of recycled paper via surface spraying carboxymethyl starch-grafted-polyacrylamide
Authors: Liang Shuai-Bo , Fu Qing-Jin , Liu Qian , Dun Xu-Ji , Yao Chun-Li 
Published: May 2020

Abstract
Paper strengthening agent is more and more important in the current papermaking industry. In this study, carboxymethyl starch-grafted-polyacrylamide (CMS-g-PAM) was synthesized via grafting polyacrylamide onto carboxymethyl starch (CMS), and added in a recycled pulp furnish to make handsheets. The structure and surface morphology of CMS-g-PAM were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy. The effects of CMS-g-PAM dosage and addition way on the properties of the paper were investigated. The results showed that CMS-g-PAM could improve the paper mechanical properties through both wet end addition and surface spraying, and surface spraying had a better improvement at the same dosage. CMS-g-PAM was more effective in improving paper mechanical properties than CMS, when it comes to the same addition way and the same dosage. SEM analysis demonstrated that CMS-g-PAM could increase the inter-fiber bonding.
Effects of pH shock on microaerobic activated sludge system with a graphene oxide/nano-magnetic powder composite
Authors: Lan Huixia , Wang Xiangzhi , Qi Shixin , Yang Da , Zhang Hao 
Published: May 2020

Abstract
Using the acclimated activated sludge from the pulping middle-stage effluent, the effect of pH shock on the micro-oxygen activated sludge system with a nano-magnetic powder/graphene oxide composite was studied. The results showed that the removal rates of chemical oxygen demand (CODCr) and ultraviolet adsorption at 254 nm (UV254) decreased. Also, the sludge settling performance was poor due to the impact of pH, but the impact resistance of nano-magnetic powder/graphene oxide group (MGO group) was higher and the recovery was faster. Results of high throughput sequencing indicated that the diversity of microbial community was reduced by the impact of pH, but it was significantly higher in MGO group than in the blank group. The dominant bacteria after pH shock or recovery in both of the system had a large difference. The percentage of the dominant bacteria in the MGO group was higher than that in the blank group. The MGO group had higher electron transfer system (ETS) activity which made the system having a strong pH impact resistance.
Are labor pain and birth experience associated with persistent pain and postpartum depression? A prospective cohort study
Authors: Rosseland Leiv Arne , Reme Silje Endresen , Simonsen Tone Breines , Thoresen Magne , Nielsen Christopher Sivert , Gran Malin Eberhard 
Published: May 2020

Abstract

Background and aims
A considerable research-literature focuses on pain during labor and associations with postpartum persistent pain and depression, with findings pointing in various directions. The aim of this study was to examine the role of labor pain and overall birth experience in the development of pain and depression 8 weeks after delivery.

Methods
The study sample was drawn from the Akershus Birth Cohort. Data from multiple sources were used, including the hospital’s birth record (n = 4,391), questionnaire data from gestational week 17 of pregnancy (n = 3,752), 8 weeks postpartum (n = 2,217), and two questions about pain and birth experience asked within 48 h after delivery (n = 1,221). The Edinburgh Postnatal Depression Scale was used to measure postpartum depression, a single question was used to measure persistent pain 8 weeks postpartum, while pain and birth experience were measured by numeric rating scales. A history of pre-pregnant depression and chronic pain were measured through self-report questions in gestational week 17. A total of 645 women had complete data from all sources. We applied multiple imputation techniques to handle missing responses on the two questions about pain and birth experience.

Results
The results showed that neither labor pain nor birth experience were associated with persistent pain 8 weeks postpartum, whereas pain before pregnancy (OR 3.70; 95% CI 2.71–5.04) and a history of depression (OR 2.31; 95% CI 1.85–2.88) were statistically significant predictors of persistent pain. A negative birth experience was significantly (OR 1.16; 95% CI 1.04–1.29) associated with postpartum depression, whereas labor pain intensity was not. A history of depression (OR 3.95; 95% CI 2.92–5.34) and pre-pregnancy pain (OR 2.03; 95% CI 1.37–3.01) were important predictors of postpartum depression 8 weeks after delivery.

Conclusions and implications
Whilst the relationship between labor pain intensity and postpartum pain and depression remain unclear, our results do imply the need to screen for previous depression and chronic pain conditions in pregnant women, as well as consider preventive measures in those who screen positive.
Synaptic Connections of Aromatase Circuits in the Medial Amygdala Are Sex Specific
Authors: Billing Addison , Henrique Correia Marcelo , Kelly Diane A. , Li Geng-Lin , Bergan Joseph F. 
Published: May 2020

AbstractThe brains of male and female mice are shaped by genetics and hormones during development. The enzyme aromatase helps establish sex differences in social behaviors and in the neural circuits that produce these behaviors. The medial amygdala of mice contains a large population of aromatase neurons and is a critical hub in the social behavior network. Moreover, the neural representation of social stimuli in the medial amygdala displays clear sex differences that track developmental changes in social behaviors. Here, we identify a potential anatomic basis for those sex differences. We found that sensory input from the accessory olfactory bulb (AOB) to aromatase neurons is derived nearly exclusively from the anterior AOB, which selectively responds to chemosensory cues from conspecific animals. Through the coordinated use of mouse transgenics and viral-based circuit-tracing strategies, we demonstrate a clear sex difference in the volume of synapses connecting the accessory olfactory bulb to aromatase-expressing neurons in the medial amygdala of male versus female mice. This difference in anatomy likely mediates, at least in part, sex differences in medial amygdala-mediated social behaviors.
Helping Parents Cope in the NICU
Authors: Haward Marlyse F. , Lantos John , Janvier Annie ,   for the POST Group
Published: May 2020

Parenting in the NICU is an intense journey. Parents struggle to build intimacy with their child amid complex emotions and medical uncertainties. They need to rapidly adapt their vision of parenthood to the realities of intensive care. The psychological impact of this journey can have important effects on their psychological health. For parents of sick older children, “good parent” beliefs have been shown to foster positive growth. This concept is also essential for parents of infants in the NICU, although their path is complex.We write as clinicians who were also families in the NICU. We suggest parents need to hear and internalize 3 important messages that overlap but are each important: you are a parent, you are not a bad parent, and you are a good parent. We offer practical suggestions to NICU clinicians that we believe will help NICU parents cope while their infant is in the NICU and afterward.
Measuring the circularity of congressional districts
Authors: Nagy Balázs , Szakál Szilvia 
Published: May 2020

AbstractShape analysis has special importance in the detection of manipulated redistricting, which is called gerrymandering. In most of the US states, this process is made by non-independent actors and often causes debates about partisan manipulation. The somewhat ambiguous concept of compactness is a standard criterion for legislative districts. In the literature, circularity is widely used as a measure of compactness, since it is a natural requirement for a district to be as circular as possible. In this paper, we introduce a novel and parameter-free circularity measure that is based on Hu moment invariants. This new measure provides a powerful tool to detect districts with abnormal shapes. We examined some districts of Arkansas, Iowa, Kansas, and Utah over several consecutive periods and redistricting plans, and also compared the results with classical circularity indexes. We found that the fall of the average circularity value of the new measure indicates potential gerrymandering.
The experimental application of steam explosion-pre-treated flaxseed meal with hypoglycaemic and lipid-lowering functions in rats on a high-fat-sugar diet
Authors: Yu G.W. , Guo T.T. , Zhou X. , Huang Q.D. , Shi X.W. 
Published: May 2020

With the increase in populations with suboptimal health and chronic diseases, consumer demands for health foods, especially food products with health functions. The flaxseed was a complex mixture mainly consisting of flaxseed oil, flaxseed protein, dietary fibre (including cellulose and flaxseed gum), carbohydrates and secoisolariciresinol diglucoside (SDG). To investigate the effects of expanded flaxseed meal (EFM) intervention on the hypoglycaemic and lipid-lowering functions of rats on a high-fat, high-sugar (HFHS) diet, EFM was fed to six groups (z = 8) of Sprague–Dawley (SD) rats: normal control, HFHS model, positive treatment control, and low-, medium-, and high-dose EFM (5%, 10% and 20% mass fraction EFM, respectively) groups. The results (8 weeks later) were as follows: (1) medium- and high-dose EFM achieved similar inhibitive effects on blood glucose levels compared with positive treatment (5.94±0.32 mmol/L); (2) all EFM doses significantly reduced total cholesterol, triglyceride and low-density lipoprotein cholesterol levels in the blood plasma of SD rats and (3) EFM significantly increased glutathione peroxidase, superoxide dismutase and catalase activities, increased glutathione levels, and reduced the malondialdehyde content in the plasma of SD rats (P < 0.05). Therefore, EFM mitigated the adverse effects produced by HFHS diet on physiological functions, effectively regulated blood glucose and lipid metabolism, enhanced plasma antioxidant capacity and alleviated oxidative stress in SD rats with a certain dose–effect relationship among the EFM dose groups. Hepatic histological morphologies indicated that EFM also improved the size and density of lipid droplets in the liver of the rats and inhibited the onset of fatty liver. These results suggest that EFM is a potentially useful raw material in the development of blood glucose and lipid-lowering food products.
Presentation and Outcomes of Patients with ESKD and COVID-19
Authors: Valeri Anthony M. , Robbins-Juarez Shelief Y. , Stevens Jacob S. , Ahn Wooin , Rao Maya K. , Radhakrishnan Jai , Gharavi Ali G. , Mohan Sumit , Husain S. Ali 
Published: May 2020

Significance Statement
Immunosuppression and a high prevalence of comorbidities among patients with ESKD on dialysis raise concerns that such patients may have an elevated risk of severe coronavirus disease 2019 (COVID-19). However, the outcomes for COVID-19 in this patient population are not clear. In their study of 59 patients with ESKD and COVID-19 receiving dialysis at a New York City medical center, the authors found that although the presentation of patients on dialysis with COVID-19 was similar to that of the general population, these patients have poor outcomes, including 31% overall mortality and 75% mortality among those requiring mechanical ventilation. In addition, higher levels of inflammatory markers associated with severe disease. This information will help inform care of patients on dialysis who develop COVID-19 and reinforces the importance of infection control measures when treating this vulnerable population.

Background
The relative immunosuppression and high prevalence of comorbidities in patients with ESKD on dialysis raise concerns that they may have an elevated risk of severe coronavirus disease 2019 (COVID-19), but outcomes for COVID-19 in such patients are unclear.

Methods
To examine presentation and outcomes of COVID-19 in patients with ESKD on dialysis, we retrospectively collected clinical data on 59 patients on dialysis who were hospitalized with COVID-19. We used Wilcoxon rank sum and Fischer exact tests to compare patients who died versus those still living.

Results
Two of the study’s 59 patients were on peritoneal dialysis, and 57 were on hemodialysis. Median age was 63 years, with high prevalence of hypertension (98%) and diabetes (69%). Patients who died were significantly older than those still living (median age, 75 versus 62 years) and had a higher median Charlson comorbidity index (8 versus 7). The most common presenting symptoms were fever (49%) and cough (39%); initial radiographs most commonly showed multifocal or bilateral opacities (59%). By end of follow-up, 18 patients (31%) died a median 6 days after hospitalization, including 75% of patients who required mechanical ventilation. Eleven of those who died had advanced directives against intubation. The remaining 41 patients (69%) were discharged home a median 8 days after admission. The median initial white blood cell count was significantly higher in patients who died compared with those still living (7.5 versus 5.7×103/μl), as was C-reactive protein (163 versus 80 mg/L).

Conclusions
The association of COVID-19 with high mortality in patients with ESKD on dialysis reinforces the need to take appropriate infection control measures to prevent COVID-19 spread in this vulnerable population.
Factores que inciden en la gestión de proyectos de investigación científica
Authors: Rosario Villarreal Marco Aurelio , Ocaña Fernández Yolvi , Capillo Chávez Cesar Herminio , Lavado Rodríguez Alejandrino Benito , El Homrani Mohammed , Arias Romero S. Mateo 
Published: May 2020

La presente investigación pretende explicar que existen factores externos, que influyen directamente en la gestión de los proyectos de investigación científica y tecnológica financiados con recursos del Fondo de desarrollo socioeconómico de Camisea (Focam) de la Universidad Nacional de Huancavelica (UNH). Dentro de estos factores externos que inciden directamente se encuentran las competencias profesionales de los docentes investigadores y la gestión logística que permite la implementación de la investigación. Se utiliza el enfoque cuantitativo, el tipo de investigación sustantiva explicativa y el diseño de investigación es no experimental de corte transversal tipo explicativo causal. La muestra censal con un tamaño de muestra de 49 docentes investigadores de Ingeniería. Para la presente investigación, se usó la técnica de la encuesta para las tres variables de estudio. Se puede afirmar que existe influencia positiva de las competencias profesionales y la gestión logística sobre la gestión de los proyectos de investigación científica financiados con recursos de Focam. Es la primera investigación que ofrece una discusión sobre en qué nivel de gestión se encuentran los proyectos de investigación científica ejecutados en la Universidad Nacional de Huancavelica, desde la planificación de la investigación hasta la publicación del artículo científico en una revista indizada. Se plantean alternativas de solución para los investigadores y para la oficina de logística que ayudarán a gestionar eficientemente los proyectos de investigación científica.
PENERAPAN METODE EDUTAINMENT MELALUI PERMAINAN SIMAK-ULANG-UCAP UNTUK MENINGKATKAN KETERAMPILAN BERBICARA BAHASA ARAB
Authors: Karima Karimna Isya 
Published: May 2020

This research based on the first grade of MTs Ar-Rohmah’s students’ Arabic speaking skills. It was caused by the lack of application of in speaking Arabic. The students often feels bored and lack of confidence. So, the researcher was interested to find out differences in student’s speaking skill using Edutainment method. This study used quantitative approach, and quasi-experimental methodology. The techniques of collecting data are observation, interviews, test learning instruments, and documentation. The results are: (1) The mean value of experimental class’ pre-test has 41,25. Meanwhile in the control class has 51,40. (2) The mean value of experimental class’ post test has 63,43, meanwhile the control class has 59,68. (3) N-Gain Score’s test shows there was an increase in experimental class amounts 43.94% or 0,43 which in the average category. Besed on the results, the application of Edutainment method with ‘Listen-Repeat-Speak’ games can improve Arabic speaking skills.
HOUSE LAYOUT TYPOLOGY STUDY IN SLUM AREA Case Study : Kampung Jawa, Denpasar, Bali
Authors: Prabawa Made Suryanatha 
Published: May 2020

Kampung Jawa is a settlement located in the heart of Denpasar, the capital city of Denpasar. These Settlement actual name was Dusun Wanasari, but people of Denpasar usually call it “Kampung Jawa”. Kampung Jawa historical background can be traced back to year 1907, when many Javanese merchant came to bali to trade. These Javanese merchant later on given a land to buil their settlement by the Kingdom Badung. From 1907 until today (2020) Kampung Jawa have grown today 10.250 people live there. Slums area, is what the government of Denpasar terminology for Kampung Jawa because it is a highly dense populated area (10.250 people in 8.945 m2 settlement area). This research depart from the issue of Kampung Jawa as a slums area becoming a Government problems, but it must be having a unique characteristics, especially for their House Layout. This research conducted using exploratory and qualitatives methods. Exploratory for findings house typology and qualitative for digging reasons behind the typology and resident’s conditions in Kampung Jawa. Results dan findings shows that resident’s of Kampung Jawa lack of education, so they lack of “Labor” aspect that then affected their “Work” and “Action” aspects. Because of lack of “Labor” residents of Kampung Jawa didn’t get to know about better living, they just live with an efficient way as long as they can survive to live in Denpasar. These thought brought themn to create an efficient land use and as a results a mixed function house layout typology. From the finding, this research can conclude that Kampung Jawa’s Residents way of living was unique and can be said that they adapt to their condition and creat a Compact House according to their own criteria-mostly their occupation.
THERMAL COMFORT INVESTIGATION ON HOLY MOSQUE IN BANDUNG Case Study : Lautze 2 Mosque Bandung
Authors: Prabowo Agung 
Published: May 2020

Abstract -Thermal comfort is a state of mind that expresses satisfaction with the thermal environment. There are two main categories in the effort to obtain a comfort index; empirical and analytical. Empirical is based on social surveys, while analysis is based on the physics principle of heat flow.Bandung city is one of the historical cities in Indonesia which has many historical heritage buidings. One of them which is commonly known as colonial buildings in Bandung is Lautze 2 Mosque, located at Tamblong Street in the city center of Bandung. This research was conducted to analyze the thermal comfort in the Lautze 2 Mosque Bandung. The analytical method used in this study is a quantitative research method by measuring the main factors namely air temperature, air humidity and air velocity. The main factors become obstacles to get thermal comfort data at the Lautze 2 Mosque Bandung is the location of buildings located in areas with tropical climate conditions with high air temperatures, high air humidity, and low air velocitys.The research conclude that thermal comfort in the Lautze 2 Mosque Bandung building can be categorized as uncomfortable, it can be seen from the measurement results of related factors, namely the temperature and humidity that exceeds the comfort limit and the low air velocity in the building becomes an obstacle to obtain thermal comfort. Keywords: colonial buildings, mosque, thermal comfort, tropical climate.