bluuebunny/crossref_metadata_2025_split huggingface dataset:
Big data-oriented energy prosumption service in smart community districts: a multi-case study perspective
Authors: Anthony Bokolo , Petersen Sobah Abbas , Ahlers Dirk , Krogstie John , Livik Klaus 
Published: December 2019

AbstractThe smart grid achieves bidirectional information and energy flow between energy consumer and utility grid, aiding energy users not only to utilize energy, but also to produce, sell, and share energy with other consumers or with the utility grid. This type of energy user is referred to as the “prosumer”. Thus, prosumer management structures are important within energy market. However, prior studies on energy sustainability has paid little attention on prosumer involvement and management. Likewise, the continuous growth of cities has increased data processing complexity. Consequently, processing and analysis of historical, online, and real-time streaming data from energy sensors and metering devices has become a major issue in smart cities. Therefore, this research aims to present an architecture based on big data to improve energy prosumption in smart community districts by applying enterprise architecture approach grounded on The Open Group Architecture Framework (TOGAF). Accordingly, qualitative methodology is adopted to collect data by employing case study by focus group interview from two energy companies in Norway to preliminarily validate the architecture. Findings from the case studies was demonstrated in ArchiMate modeling language to evaluate the applicability of the architecture. Moreover, findings from this study provides practical scenario that energy service providers can refer to in designing their own energy data platforms. Essentially, the architecture can be utilized as a guide to help municipalities and policy makers in creating approach for energy data analytics in smart community districts towards making decisions for future energy prosumption planning.
BMPR1A and BMPR1B Missense Mutations Cause Primary Ovarian Insufficiency
Authors: Renault Lucie , Patiño Liliana C , Magnin Françoise , Delemer Brigitte , Young Jacques , Laissue Paul , Binart Nadine , Beau Isabelle 
Published: December 2019

Abstract

Context
Primary ovarian insufficiency (POI) is a frequently occurring disorder affecting approximately 1% of women under 40 years of age. POI, which is characterized by the premature depletion of ovarian follicles and elevated plasma levels of follicle-stimulating hormone, leads to infertility. Although various etiological factors have been described, including chromosomal abnormalities and gene mutations, most cases remain idiopathic.

Objective
To identify and to functionally validate new sequence variants in 2 genes that play a key role in mammalian ovarian function, BMPR1A and BMPR1B (encoding for bone morphogenic protein receptor), leading to POI.

Methods
The impact on bone morphogenic protein (BMP) signaling of BMPR1A and BMPR1B variants, previously identified by whole-exome sequencing on 69 women affected by isolated POI, was established by different in vitro functional experiments.

Results
We demonstrate that the BMPR1A-p.Arg442His and BMPR1B-p.Phe272Leu variants are correctly expressed and located but lead to an impairment of downstream BMP signaling.

Conclusion
In accordance with infertility observed in mice lacking Bmpr1a in the ovaries and in Bmpr1b-/- mice, our results unveil, for the first time, a link between BMPR1A and BMPR1B variants and the origin of POI. We show that BMP signaling impairment through specific BMPR1A and BMPR1B variants is a novel pathophysiological mechanism involved in human POI. We consider that BMPR1A and BMPR1B variants constitute genetic biomarkers of the origin of POI and have clinical utility.
Serum SHBG Is Associated With the Development and Regression of Nonalcoholic Fatty Liver Disease: A Prospective Study
Authors: Wang Xu , Xie Jiewen , Pang Juan , Zhang Hanyue , Chen Xu , Lin Jiesheng , Li Qing , Chen Qian , Ma Jing , Xu Xiping , Yang Yan , Ling Wenhua , Chen Yuming 
Published: December 2019

Abstract

Context
SHBG, a homodimeric glycoprotein produced by hepatocytes has been shown to be associated with metabolic disorders. Whether circulating SHBG levels are predictive of later risk of nonalcoholic fatty liver disease (NAFLD) remains unknown. In this study, we prospectively investigated the association between SHBG and NAFLD progression through a community-based cohort comprising 3389 Chinese adults.

Methods
NAFLD was diagnosed using abdominal ultrasonography. Serum SHBG levels were measured by chemiluminescent enzyme immunometric assay, and their relationship with NAFLD development and regression was investigated after a mean follow-up of 3.09 years using multivariable logistic regression.

Results
Basal SHBG was negatively associated with NAFLD development, with a fully adjusted odds ratio (OR) and its 95% confidence interval (CI) of 0.22 (0.12-0.40) (P &lt; .001). In contrast, basal SHBG was positively associated with NAFLD regression, with a fully adjusted OR of 4.83 (2.38-9.81) (P &lt; .001). Multiple-stepwise logistic regression analysis showed that SHBG concentration was an independent predictor of NAFLD development (OR, 0.28 [0.18-0.45]; P &lt; .001) and regression (OR, 3.89 [2.43-6.22]; P &lt; .001). In addition, the area under the receiver operating characteristic curves were 0.764 (95% CI, 0.740-0.787) and 0.762 (95% CI, 0.738-0.785) for the prediction models of NAFLD development and regression, respectively.

Conclusions
Serum SHBG concentration is associated with the development and regression of NAFLD; moreover, it can be a potential biomarker for predicting NAFLD progression, and also a novel preventive and therapeutic target for NAFLD.
Muscle Strength, Size, and Composition Following 12 Months of Gender-affirming Treatment in Transgender Individuals
Authors: Wiik Anna , Lundberg Tommy R , Rullman Eric , Andersson Daniel P , Holmberg Mats , Mandić Mirko , Brismar Torkel B , Dahlqvist Leinhard Olof , Chanpen Setareh , Flanagan John N , Arver Stefan , Gustafsson Thomas 
Published: December 2019

Abstract

Context
As many sports are divided in male/female categories, governing bodies have formed regulations on the eligibility for transgender individuals to compete in these categories. Yet, the magnitude of change in muscle mass and strength with gender-affirming treatment remains insufficiently explored.

Objective
This study explored the effects of gender-affirming treatment on muscle function, size, and composition during 12 months of therapy.

Design, settings, participants
In this single-center observational cohort study, untrained transgender women (TW, n = 11) and transgender men (TM, n = 12), approved to start gender-affirming medical interventions, underwent assessments at baseline, 4 weeks after gonadal suppression of endogenous hormones but before hormone replacement, and 4 and 12 months after treatment initiation.

Main outcome measures
Knee extensor and flexor strength were assessed at all examination time points, and muscle size and radiological density (using magnetic resonance imaging and computed tomography) at baseline and 12 months after treatment initiation.

Results
Thigh muscle volume increased (15%) in TM, which was paralleled by increased quadriceps cross-sectional area (CSA) (15%) and radiological density (6%). In TW, the corresponding parameters decreased by –5% (muscle volume) and –4% (CSA), while density remained unaltered. The TM increased strength over the assessment period, while the TW generally maintained their strength levels.

Conclusions
One year of gender-affirming treatment resulted in robust increases in muscle mass and strength in TM, but modest changes in TW. These findings add new knowledge on the magnitude of changes in muscle function, size, and composition with cross-hormone therapy, which could be relevant when evaluating the transgender eligibility rules for athletic competitions.
Episodic Muscle Disorders
Authors: Sansone Valeria A. 
Published: December 2019

ABSTRACT

PURPOSE OF REVIEW
This article reviews the episodic muscle disorders, including benign cramp-fasciculation syndrome, the periodic paralyses, and the nondystrophic myotonias. The core diagnostic criteria for a diagnosis of primary periodic paralysis, including clues to distinguish between the hypokalemic and hyperkalemic forms, and the distinctive elements that characterize Andersen-Tawil syndrome are discussed. Management of patients with these disorders is also discussed.

RECENT FINDINGS
Childhood presentations of periodic paralysis have recently been described, including atypical findings. Carbonic anhydrase inhibitors, such as dichlorphenamide, have recently been approved by the US Food and Drug Administration (FDA) for the treatment of both hypokalemic and hyperkalemic forms of periodic paralysis. Muscle MRI may be a useful outcome measure in pharmacologic trials in periodic paralysis. Genetic research continues to identify additional gene mutations responsible for periodic paralysis.

SUMMARY
This article will help neurologists diagnose and manage episodic muscle disorders and, in particular, the periodic paralyses and the nondystrophic myotonias.
Lambert-Eaton Myasthenic Syndrome, Botulism, and Immune Checkpoint Inhibitor–Related Myasthenia Gravis
Authors: Guidon Amanda C. 
Published: December 2019

ABSTRACT

PURPOSE OF REVIEW
This article reviews the pathophysiology, epidemiology, clinical presentation, diagnosis, and treatment of Lambert-Eaton myasthenic syndrome (LEMS) and of botulism, and immune-related myasthenia gravis (MG) occurring in the context of immune checkpoint inhibitor therapy for cancer.

RECENT FINDINGS
The suspicion that LEMS is rare but also likely underdiagnosed is supported by recent epidemiologic data. A validated, LEMS-specific scale now exists to assess and monitor disease, and symptomatic and immunomodulatory treatments are available. As presynaptic disorders of neuromuscular transmission, LEMS and botulism share electrodiagnostic abnormalities but have important distinguishing features. Knowledge of the clinical features of botulism is needed, particularly with continued cases of infant botulism, the opioid epidemic increasing the incidence of wound botulism, and medical use of botulinum toxin, which may cause iatrogenic botulism. Foodborne botulism remains rare. Prompt recognition of botulism and administration of antitoxin can improve outcomes. MG may be exacerbated or may present de novo in the context of immune activation from immune checkpoint inhibitor therapies for cancer. Immune-related MG commonly overlaps with myositis and myocarditis. Corticosteroids typically result in improvement. However, immune-related MG can be more fulminant than its idiopathic counterpart and may cause permanent disability or death.

SUMMARY
The diagnosis of LEMS, botulism, or immune-related MG can generally be made from the patient’s history, supplemented with directed questions, a physical examination designed to demonstrate abnormalities, and laboratory and electrodiagnostic testing. Early diagnosis and carefully selected treatment not only improve outcomes of the neuromuscular disease but can affect the prognosis of underlying malignancy, when present.
Case Report: Acute pancreatitis as a complication for the use of furosemide during transurethral resection of the prostate
Authors: Grandez-Urbina J. Antonio , Santillan-Romero Anggie , Corrales-Acosta Mariela , Tejeda-Mariaca J. Eduardo , Fernandez-Luque J. Luis 
Published: December 2019

Background: Pancreatitis caused after transurethral resection of the prostate (TURP) is an uncommon complication, with few reports found in the literature. Here we present the case of a middle-aged patient without comorbidities with this pathology. Clinical case: A 66-year-old male patient with no prior medical history underwent TURP surgery due to benign prostatic hyperplasia. The evolution was unfavourable, leading to post TURP syndrome. On the fifth day after surgery, the patient was admitted for emergency dialysis. During his emergency stay, the patient was unstable; he was diagnosed with pancreatitis, moving to an intensive care unit for management The patient progressed favourably from renal failure and pancreatitis, and on the 5th day the patient was discharged, tolerating oral feeding and stabilized renal failure. Conclusions: Pancreatitis caused by TURP is very rare. This complication has been reported in the literature infrequently and should be suspected when there is pain in the epigastrium. If this complication is suspected, imaging tests and pancreatic enzyme levels should be immediately requested, as it can have an unfavourable evolution until death.
Population-based palliative care planning in Ireland: how many people will live and die with serious illness to 2046?
Authors: May Peter , Johnston Bridget M. , Normand Charles , Higginson Irene J. , Kenny Rose Anne , Ryan Karen 
Published: December 2019

Background: All countries face growing demand for palliative care services. Projections of need are essential to plan care in an era of demographic change. We aim to estimate palliative care needs in Ireland from 2016 to 2046. Methods: Static modelling of secondary data. First, we estimate the numbers of people in Ireland who will die from a disease associated with palliative care need. We combine government statistics on cause of death (2007-2015) and projected mortality (2016-2046). Second, we combine these statistics with survey data to estimate numbers of people aged 50+ living and dying with diseases associated with palliative care need. Third, we use these projections and survey data to estimate disability burden, pain prevalence and health care utilisation among people aged 50+ living and dying with serious medical illness. Results: In 2016, the number of people dying annually from a disease indicating palliative care need was estimated as 22,806, and the number of people not in the last year of life aged 50+ with a relevant diagnosis was estimated as 290,185. Equivalent estimates for 2046 are 40,355 and 548,105, increases of 84% and 89% respectively. These groups account disproportionately for disability burden, pain prevalence and health care use among older people, meaning that population health burdens and health care use will increase significantly in the next three decades. Conclusion: The global population is ageing, although significant differences in intensity of ageing can be seen between countries. Prevalence of palliative care need in Ireland will nearly double over 30 years, reflecting Ireland’s relatively young population. People living with a serious disease outnumber those in the last year of life by approximately 12:1, necessitating implementation of integrated palliative care across the disease trajectory. Urgent steps on funding, workforce development and service provision are required to address these challenges.
Knowledge of immunosuppressive drugs used in kidney transplants
Authors: Mohamad Mas Linda , Yang Li , Jin Xu , Eng Priscilla Tan Lee , Shern Terence Kee Yi 
Published: December 2019

Aim: A key role of renal nurses is the correct and safe administration of immunosuppressive drug therapy (ImmRx) to kidney transplant recipients. The authors sought to examine the knowledge and competency of ImmRx in kidney transplant patients and whether an annual kidney transplant nurse education programme had any beneficial effects. Methods: The study population was comprised of 63.2% (n=50/79) of all nurses from renal wards (ward A (n=17/35), ward B (n=21/32)) and 12 nurses from a high-dependency urology ward (ward C (n=12)). Kidney transplant patients usually receive inpatient care in wards A, B or C only as these wards specialise in urology and renal care. Each nurse completed a 35-question test that covered ImmRx in areas of indication, identification, interaction, pharmcokinetics/pharmacodynamics, therapeutic drug monitoring, administration and adverse effects. A minimum score of 70% was required to pass the test. Results: Only 46% of participants passed the test. The proportion of nurses who passed was not significantly different with respect to years of nursing experience, professional rank, postgraduate nursing qualifications or ward location. Unexpectedly, a greater proportion of nurses who did not attend the education programme passed the test (63.6%; n=14/22) than those who did attend it (32.1%; n=9/28]; p=0.03). Notably, 24% (n=12/50), 4% (n=2/50) and 4% (n=2/50) were unable to correctly answer any of the identification, interaction and therapeutic drug monitoring questions. Conclusion: These findings suggest that the nurses' understanding and knowledge of ImmRx is insufficient and they need to update their knowledge on ImmRx continually.
Morphoagronomic characterization of sweet potato accessions from the germplasm bank of Embrapa hortaliças
Authors: De Sousa Rosa maria de Deus , Peixoto José Ricardo , Amaro Geovani Bernardo , Vilela Michelle Sousa , Carmona Paula Andrea Osorio 
Published: December 2019

Studies on the determination of genetic divergence among genotypes are important tools in breeding programs, contributing to the identification of parents with considerable productive potential. However, little is known about the combinatorial capacity of sweet potato (Ipomoea batatas) accessions and its adaptation to the different regions of Brazil. The objective of this study was to evaluate the morpho-agronomic traits from 102 sweet potato accessions from the Germplasm Bank of Embrapa Hortaliças. The experiment was laid out as an augmented block design comprised of 102 treatments. Nineteen above ground traits were measured using descriptors for the respective parts. Estimated values of broad sense heritability were high for the traits mean branch length (95.75%), immature leaf color (85.06%), and predominant branch color (90.57%). Coefficients of environmental variation were below 30.00% for all variables, except for branch weight (51.62%). The 102 clones analyzed presented broad genetic variability for the different traits evaluated, especially for branch weight, and branch length, and mature leaf color.
A comunidade científica brasileira: Formação ao longo dos séculos
Authors: Tuma Ana Beatriz Camargo 
Published: December 2019

Este texto é uma resenha crítica do livro “Um espaço para a ciência: Formação da comunidade científi ca no Brasil” de Simon Schwartzman (2015), publicado pela primeira vez em 1979. Nele, aborda-se a ciência brasileira desde o período colonial até os dias atuais. O mérito mais relevante desta obra, segundo o autor, foi o de ter ajudado a estabelecer o campo dos estudos sociais e históricos sobre a ciência e tecnologia no Brasil.
Palavras-chave: Brasil; ciência; cientistas; história.
Alterações da personalidade na demência: Uma revisão
Authors: Henriques-Calado Joana , Duarte-Silva Maria Eugénia 
Published: December 2019

Objetivou-se analisar estudos empíricos sobre as alterações da personalidade na Demência, através da avaliação dos traços baseada no Modelo dos Cinco Fatores da Personalidade. Procedeu-se a revisão da literatura indexada nas bases de dados EBSCO/Web of Knowledge/Medline/Pubmed/SciELO/Scopus. Foram incluídas 57 referências. As alterações da personalidade são evidentes nas fases iniciais da Demência e podem ser um marcador clínico precoce. Um dado parece ser transversal e geralmente unânime na literatura, evidencia-se um aumento na dimensão Neuroticismo e um decréscimo na dimensão Conscienciosidade. Sugere-se a necessidade de exploração sistemática, para que seja introduzida uma avaliação da personalidade, no diagnóstico de Demência de Alzheimer, de forma a aumentar a sensibilidade do diagnóstico precoce e com utilidade prática ao nível do diagnóstico clínico.
Uma análise exploratória das relações entre as representações de vinculação do pai e o seu envolvimento em atividades práticas e lúdicas.
Authors: Monteiro Lígia , Maia Rita , Fernandes Carla , Fernandes Marília , Antunes Marta , Veríssimo Manuela 
Published: December 2019

Este estudo teve como principal objetivo explorar as relações entre as representações de vinculação (script de base segura) do pai, e o seu envolvimento em atividades práticas (relacionadas com a gestão e cuidados à criança) e em atividades com características lúdicas (brincadeira/lazer). Participaram 62 famílias nucleares, com crianças entre os 2 e os 5 anos, de estatuto socioeconómico médio e de duplo-rendimento. De modo a analisar os scripts de base segura utilizou-se as Narrativas de Representação da Vinculação em Adultos, aplicadas individualmente ao pai, tendo a mãe e o pai preenchido, de modo independente, um questionário sobre o envolvimento parental. Os resultados indicam que os pais possuem e acedem ao script de base segura em contextos onde este é elicitado; que participam mais nas atividades lúdicas, do que nas práticas; e que pais com valores mais elevados de script adulto/criança se encontram mais envolvidos nas atividades práticas, mesmo quando a idade da criança e as habilitações do pai são controladas.
Libro álbum: un camino de creación literaria y trabajo colaborativo con niños y niñas
Authors: Lozano Johanna Paola , Moreno Luisa Fernanda , Vargas Nazly Giselle 
Published: December 2019

Este artículo describe una propuesta metodológica y un camino de descubrimientos en el proceso de investigación/creación, que comienza con la realización dellibro álbum La coleccionista de abuelas y continúa con una apuesta por el trabajo en colaboración con niños como coautores, escritores e ilustradores de un libro álbum para público infantil.
Antibacterial Activity and Chemical Composition of Red Peacock Flower (Caesalpinia pulcherrima L.) Leaf Essential Oil
Authors: Constani Novena Risnalani Rintank , Soetjipto Hartati , Hartini Sri 
Published: December 2019

Peacock flower (Caesalpinia pulcherrima L.) leaves contain essential oils which can be used as an ingredient in cosmetics, perfume, aromatherapy, medicine, and supplements. The study was conducted to obtain essential oils from peacock flower leaves and determine the antibacterial activity against gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus) and gram-negative (Escherichia coli and Pseudomonas aeruginosa). Antibacterial activity test was carried out by the agar diffusion method, using paper discs. Measurements were made for the inhibition zone diameter (IZD) that appeared, while the essential oil component was analyzed using GC-MS. The results showed that the peacock flower leaves (C. pulcherrima) had a moderate to strong antibacterial effect at a concentration of 7.5%-20% against gram-positive bacteria (B. subtilis and S. aureus) and gram-negative bacteria (E. coli and P. aeruginosa). Gram-negative E. coli bacteria are relatively more sensitive to peacock flower leaf essential oil compared to other test bacteria. Peacock flower (C. pulcherrima) leaf essential oil is composed of 7 main components namely β-Cubebene 33.87%; Caryophyllene 23.00%; γ-Elemene 13.18%; α-Pinene 10.96%; Cadina-1(10),4-diene 10.20%; Copaene; 7.09%; β-Pinene 1.70%.