bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship of diabetic retinopathy and systemic complications of diabetes
Authors: Amruth C Kumar , Priya N Vishnu , Deepthi P Ramya , Sowmya P 
Published: March 2020

: To study the relationship of diabetic retinopathy with systemic complications of diabetes.: Study was conducted on 310 diabetic patients attending to Narayana medical college ophthalmology opd in Nellore between August 2017and June 2018. Patients are categorized into five groups based on the duration and severity of DR into No DR, Mild NPDR, ModerateNPDR, Severe NPDR, PDR according to the ETDRS classification. All the above patients evaluated clinically, and required investigations were done for the presence of systemic complications like nephropathy, neuropathy, cardiovascular, cerebrovascular, and diabetic foot. The relation between the duration of diabetes mellitus and stage of diabetic retinopathy and also with systemic complications assessed. A total of 310 diabetic patients with a mean age of 56.5 + 11.8 years and males 211(31.7%) and females99(31.7%). Prevalence of Diabetic retinopathy was 108(34.8%) of which mild NPDR44(41.9%), moderate NPDR35(34.5%), severe NPDR 19(18.3%)and PDR10(11.4%). A significant association (P&#60;0.001) was observed between the duration of diabetes and the presence and severity of diabetic retinopathy. The overall prevalence of nephropathy, neuropathy, diabetic foot, CVS, CAD was 52.6%and they were significantly (p&#60;0.05) more common in patients with DR (64.8%) as compared to those with no DR (43.5%) and complications increased with severity of retinopathy.
A retrospective study: impact of various phases of menstrual cycle on corneal pachymetry
Authors: Kardam Vyas Aneesha , Rana Poonam , N Kothari R , Patel Zeel , Soni Avani 
Published: March 2020

To evaluate the effect of the various phases of menstrual cycle on corneal pachymetry. 100 female participants were selected retrospectively, who underwent a through screening and ophthalmic evaluation. Corneal pachymetry was measured using an ultrasound pachymeter. Readings of both the eyes were taken on day 1-3, day 13-15 and day 26-28 of the menstrual cycle. An intergroup comparison was carried out and statistical significance was found. It was found that the corneal thickness was at its thickest i.e. 547.51± 31.824 on day 13-15 which coincides with ovulation and thinnest i.e. 548.25± 29.948on day 1-3 of the menstrual cycle (p&#60;0.000). All in all, we conclude that hormonal changes do affect the ocular structures in a profound manner. In view of the cornea, they have a role in disturbing the pump mechanism of corneal endothelium, especially when oestrogen levels are at their highest. This eventually leads to a physiological increase in corneal thickness due to corneal edema and having an indirect effect on visual acuity and corneal sensitivity and intraocular measurement.
A prospective observational study to evaluate the etiology and staging of neovascular glaucoma
Authors: Kuruba Mayuri Totli , Sultana Khayoom Nishat 
Published: March 2020

To identify the most common cause and the frequent stage of presentation in patients with neovascular glaucoma.The present study is a prospective observational study. 136 eyes of 109 patients having neovascular glaucoma in one eye or both the eyes were included in the study. All patients underwent thorough ocular examination i.e., visual acuity, slit lamp bio-microscopy, intraocular pressure (IOP) measurement by Goldmannapplanation tonometry, gonioscopy with Posner 4 mirror indirect gonioscope and dilated fundus examination. Neovascularization of iris (NVI) was identified in an undilated state, presence of any ectropionuveae, hyphema, anterior chamber reaction, pseudoexfoliative material, keratic precipitates and other signs of uveitis were noted. The number of quadrants of the angle having neovascularization was noted.The mean age was 57.59 ± 12.6 years, 80.73% were males and 19.26% were females. Mean IOP was 27.14 ± 11.3 mm of Hg. 74 (54.4%) presented in rubeosisiridis stage, 38 (27.9%) in angle closure stage and 24 (17.6%) in open angle stage. 89 (65.4%) had diabetic retinopathy in variable severity, 16 (11.7%) had uveitis and 14 (10.2%) had retinal vein occlusion. Mean IOP angle closure stage was found to be 36.53±16.259 mm of Hg which is significantly higher than the other two stages ( = 0.000) In the present study, it was found that Proliferative diabetic retinopathy is the most common cause and rubeosisiridis is the most common stage of presentation in NVG.
The effect of variety and degree of maturity of the fruit on the organoleptic characteristics of candied zucchini
Authors: Sannikova T. A. , Machulkina V. A. , Pavlov L. V. , Gulin A. V. 
Published: March 2020

Relevance. Squashes are a promising culture, and the recent work of breeders allow us to uncover large reserves to improve their nutritional and dietary qualities. The dietary value of zucchini is due to the easy digestibility of all carbohydrates, which allows them to be used in the production of canned foods. Canned snacks and candied fruits are produced from zucchini. The most important quality of the varieties we study is their cylindrical shape, allowing mechanization of the cleaning operation.Methods. Therefore, the purpose of this work was to use zucchini of different degrees of ripeness for the preparation of candied fruit with the least loss of products.Results. As a result of research conducted at the All-Russian Research Institute of Irrigated Vegetable and Melon-Growing in the Astrakhan Region, it was found that zucchini fruits of different degrees of maturity can be used to make candied fruits, but the highest yield was obtained from mature squash, and amounted to 654 kg from the Sosnovsky variety , in the Orange variety 696 kg from one ton of prepared raw material, while in the Orange variety of candied fruits it was obtained 42-64 kg more than in the Sosnovsky variety, depending on the degree of ripening STI. The tasting committee rated candied fruits obtained from the fruit of the zucchini of the Orange variety higher by 0.3-0.5 points than from the Sosnovsky variety. In terms of chemical composition, candied fruits prepared from the raw material of ripe zucchini fruits exceeded 1.2-1.5 times - from unripe fruits. Ready candied fruits can be used as an independent form, as well as for the preparation of other types of products in the food industry.
Relationship of Non Structural Antigen 1 (NS1) Examination Results To Clinical Signs ,Symptoms and Routine Blood Examination In Patients Suspected Dengue Infections at inpatients Clinic of Vita Medika Kepung Kediri Districts
Authors: Charisma Acivrida Mega 
Published: March 2020

Early diagnosis of dengue infection is important because late diagnostic can be fatal to the patient, remembered the journey of the disease is very rapid. Currently there has been developed an examination of a non structural 1 dengue antigen (NS1) that can detect dengue viral infections earlier, even on the first day of fever. However, not all health care centers have adequate laboratory facilities for NS1 checks.Clinical symptoms and signs as well as a routine blood test are indicators that become the basis of diagnosis in health care facilities with limited facilities. This study aims to determine the relationship of NS1 examination result to clinical symptoms and signs as well as the result of routine blood tests in patients suspected dengue infection. This research uses observational analytic method with cross sectional approach. The research was conducted in clinic laboratory and inpatient clinic room of Vita Medika Kepung Kediri from November 2017 to February 2018.The number of research samples of 30 people was determined by the consecutive sampling technique. NS1 examination was done by using rapid immunochromatography test method with mono kits. Routine blood examination was done by using Micros 60. Chi square test on relationship between clinical sign and symptoms examination of dengue with the results of NS1 examination obtained p= 0,310 (p > 0,005), while the results of chi square test on the relationship of routine blood examination results haemoglobine levels, amount of leucocyte, platelet count and hematocite of NS1 examination result obtained p value in a row p = 0,235 (p > 0,05) , p = 0,013(p < 0,05) , p = 0,028(p < 0,05) dan p = 0,132 (p > 0,05). There was a significant correlation between leucocyte count and platelet count to NS1 antigen exanimation result , but there was no correlation between clinical signs and symptoms of dengue patients, haemoglobine level and haematocryt value on NS1 antigen examination result.
Russian Twitter Accounts and the Partisan Polarization of Vaccine Discourse, 2015–2017
Authors: Walter Dror , Ophir Yotam , Jamieson Kathleen Hall 
Published: March 2020

Objectives. To understand how Twitter accounts operated by the Russian Internet Research Agency (IRA) discussed vaccines to increase the credibility of their manufactured personas. Methods. We analyzed 2.82 million tweets published by 2689 IRA accounts between 2015 and 2017. Combining unsupervised machine learning and network analysis to identify “thematic personas” (i.e., accounts that consistently share the same topics), we analyzed the ways in which each discussed vaccines. Results. We found differences in volume and valence of vaccine-related tweets among 9 thematic personas. Pro-Trump personas were more likely to express antivaccine sentiment. Anti-Trump personas expressed support for vaccination. Others offered a balanced valence, talked about vaccines neutrally, or did not tweet about vaccines. Conclusions. IRA-operated accounts discussed vaccines in manners consistent with fabricated US identities. Public Health Implications. IRA accounts discussed vaccines online in ways that evoked political identities. This could exacerbate recently emerging partisan gaps relating to vaccine misinformation, as differently valenced messages were targeted at different segments of the US public. These sophisticated targeting efforts, if repeated and increased in reach, could reduce vaccination rates and magnify health disparities.
Patient Centred Medical Home (PCMH) transitions in western Sydney, Australia: A qualitative study
Authors: Metusela Christine , Usherwood Tim , Lawson Kenny , Angus Lisa , Kmet Walter , Ferdousi Shahana , Reath Jennifer 
Published: March 2020

Abstract
Background
Patient Centred Medical Homes (PCMHs), increasingly evidenced to provide high quality primary care, are new to Australia. To learn how this promising new healthcare model works in an Australian setting we explored experiences of healthcare providers in outer urban Sydney, where a number of practices are transitioning from traditional Australian general practice models to incorporate elements of PCMH approaches.
Methods
We collected qualitative data from semi-structured interviews with healthcare providers working in a range of transitioning practices and thematically analysed the data. We interviewed 35 participants including general practitioners, practice managers and practice nurses from 25 purposively sampled general practices in western Sydney, Australia, seeking maximal variation in practice size, patient demographics and type of engagement in practice transformation.
Results
Interviewees described PCMH transformation highlighting the importance of whole of practice engagement with a shared vision; key strategies for transformation to PCMH models of care including leadership, training and supportive information technology; structures and processes required to provide team-based, data-driven care; and constraints such as lack of space and the current Australian fee-for-service general practice funding model. They also reported their perceptions of early outcomes of the PCMH model of care, describing enhanced patient and staff satisfaction and also noting fewer hospital admissions, as likely to reduce costs of care.
Conclusions
Our study exploring the experience of early adopters of PCMH models of care in Australia, informs the international movement towards PCMH models of care. Our findings provide guidance for practices considering similar transitions and describe the challenges of such transitions within a fee-for-service payment system.
Robotic radical antegrade modular pancreatosplenectomy(RAMPS) versus standard retrograde pancreatosplenectomy (SRPS):study protocol for a randomized controlled trial
Authors: Zhang Gong , Liu Rong , Kang Yuhao , Zhang Haifeng , Wang Fei 
Published: March 2020

Abstract
Abstract

Background
There has been data from meta-analysis suggesting that RAMPS is a safe and effective procedure for adenocarcinoma in the body or tail of the pancreas and is oncologically superior to SRPS. However, previous studies on RAMPS were conducted under the open and laparoscopic surgery. Robotic surgery, on the other hand, plays a role in ergonomics and offers several advantages, including less fatigue, tremor filtering, 7° of wrist-like motion, motion scaling, and three-dimensional vision. At present, there is still a lack of clinical studies to observe the safety and clinical efficacy of Robotic RAMPS in the world. Hence,prospective randomized controlled trials (RCTs) comparing Robotic RAMPS and SRPS are required. We begin a RCT trial to compare short-term surgical and oncological outcomes of Robotic RAMPS and SRPS for patients with distal pancreatectomy.Methods

This is a randomized, single-center clinical trial. All included adults are patients with primary carcinoma of the distal pancreatectomy. A total of 246 patients will be randomly allocated to Robotic RAMPS or SRPS. The primary endpoints are oncological outcomes(R0 rate, number of Lymph node). Secondary endpoints are the perioperative complications, Perioperative indicators(operative time,blood loss,blood transfusion volume,costs).Discussion

To evaluate the surgical and oncological outcomes of Robotic RAMPS, we therefore undertake a prospective RCT. This procedure may become a standard approach to robotic pancreatosplenectomy.
H19/miR-194/E2F3 regulating loop promotes gastric cancer growth and metastasis
Authors: Qin Wanxiang , Shi Ying , Zhu Dan , Chen Yaohua , Li Yuping , Cui Jian 
Published: March 2020

Abstract
Background
Gastric cancer (GC) is one of the most frequent malignant digestive tumors and second fatal cancer. This study was to investigate whether lncRNA-H19 can regulate E2F3 expression through competitive binding to microRNA-194 (miR-194), thus regulating GC growth and metastasis.
Methods
H19, miR-194, and E2F3 expression levels in GC tissues and cell lines were investigated using quantitative reverse transcriptase-polymerase chain reaction (QRT-PCR). Meanwhile, the mRNA levels of H19 and E2F3 in gastric cancer tissues were also analyzed through the GEPIA web tool. The binding condition of miR-194 with H19 and E2F3 was investigated using a dual-luciferase reporter gene assay. The regulatory effects of H19 on proliferative, migratory, and invasive abilities of AGS cells and SGC-7901 cells were detected by transwell assay and cell counting kit-8 (CCK-8). Genes involved in proliferation, migration, and invasion (PCNA, Vimentin, and N-cadherin) were determined using QRT-PCR and western blot. The regulatory interaction between H19 and miR-194, miR-194, and E2F3 were investigated using rescue experiments.
Results
The results revealed that H19 was highly expressed in GC tissues and cell lines than those of controls. Downregulated H19 decreased the proliferation, migration, and invasion of AGS cells and SGC-7901 cells. H19 was demonstrated that being the molecular sponge of miR-194 in regulating the growth of the GC cells. The level of E2F3 expression was also found significantly higher in GC tissues and cell lines than those of controls. And then, the mimics of miR-194 inhibited the expression of E2F3 in the GC cells. CCK-8 assay showed decreased proliferative ability induced by miR-194 mimics were reversed by E2F3 overexpression. Transwell assays showed decreased migratory and invasive ability induced by miR-194 mimics were reversed by E2F3 overexpression.
Conclusions
This study demonstrates that H19 promotes GC growth and metastasis by regulating E2F3 via competitive binding to miRNA-194.
Hospitalization burden and comorbidities of patients with rheumatoid arthritis in Spain during the period 2002-2017
Authors: Gil-Conesa Mario , Del-Moral-Luque Juan Antonio , Gil-Prieto Ruth , Gil-de-Miguel Ángel , Mazzuccheli-Esteban Ramón , Caravaca Gil Rodriguez 
Published: March 2020

Abstract
Background: Rheumatoid arthritis (RA) is a chronic autoimmune rheumatic disease that is associated with multiple comorbidities and has a significant economic impact on the Spanish health system. The objective of this study was to estimate the rates of hospitalization of rheumatoid arthritis in Spain, and describing hospitalization rates and it's changing by age, region, RA variant, and when RA as a main cause of hospitalization or a comorbidity.

Methods: Observational descriptive study that reviewed hospital records from the CMBD. We included all hospitalizations of patients in Spain whose main diagnosis or comorbidity in the ICD-9-CM was rheumatoid arthritis during the period of 2002-2017.

Results: A total of 315,190 hospitalizations with the RA code were recorded; 67.3% were in women. The mean age of the patients was 68.5 ± 13.9 years. The median length of hospital stay was 7 days (IQR 3-11 days). In 29,809 of the admissions, RA was coded as the main diagnosis (9.4%). When RA was not coded as the main diagnosis, the most frequent main diagnoses were diseases of the circulatory system (18.9%) and diseases of the respiratory system (17.4%). The hospitalization rate during the period of 2002-2017 was 43.8 (95% CI: 43.7-44.0) per 100,000 inhabitants. The total cost for the healthcare system was 1.476 million euros, with a median of 3,542 euros per hospitalization (IQR 2,646-5,222 euros).

Conclusions: In Spain, the hospitalization rate of patients with RA increased during the study period, despite the decrease in the hospitalization rate when RA was the main diagnosis.
Severity and prevalence of various types of mental ill-health in a general adult population: Age and sex differences
Authors: Höglund Per , Hakelind Camilla , Nordin Steven 
Published: March 2020

Abstract
Background Taking a broad approach, the aim of this study was to better understand the extent of severity and prevalence in various types of mental ill-health across age groups and sexes in the general adult population. A first objective was to determine symptom severity of anxiety, depression, insomnia, burnout and somatization in combinations of different age groups and sex. A second objective was to determine prevalence of caseness of these types of mental ill-health in both absolute and relative terms in the combinations of age groups and sex. Methods Cross-sectional data based on validated questionnaire instruments were used from the Västerbotten Environmental Health Study in Sweden. In total, 3406 participants, aged 18 to 79 years, constituted a random sample stratified for age and sex. Results Severity and prevalence of anxiety, insomnia and burnout were high among women, in particular young women, and lower in older age groups. The prevalence rates for insomnia, burnout and somatization were particularly high based on the used cut-off scores. Men aged 30-49 years had the highest prevalence for mental ill-health compared to other age groups among men. Men and women aged 60-69 years had generally the lowest symptom severity and caseness. The prevalence for depression was similar in men and women in all age groups, whereas sex-related differences in extent in general were largest in the youngest age group, and gradually decreased with age. Conclusion The results suggest that focus in primary healthcare needs to be directed primarily towards insomnia, burnout and somatization as well as on young women.
The Interleukin 1 Receptor Type 1 Variant rs2234651 is a Risk Factor for Coronary Artery Disease in a Chinese Han Population: A Case Control Study
Authors: Gu Jiayi , Zhou Ping , Wei Yongyue , Gao Wei , Yang Yujiao , Liu Ying , Wang Lijuan , Lu Xiang , Liu Zhengxia 
Published: March 2020

Abstract
Background While increased expression of soluble CD121a (Interleukin 1 Receptor Type 1, IL-1R1) has been shown to be significantly correlated with the severity of coronary artery disease (CAD), it is not yet clear whether IL-1R1 gene variants impact CAD pathogenesis. Methods The present study evaluated the effects of IL-1R1 variants on CAD in a Chinese-Han population; A two-stage case-control study assessed 928 Chinese-Han patients via coronary arteriography for coronary atherosclerosis. The allele and genotype frequencies of the analyzed IL-1R1 polymorphisms were determined via a polymerase chain reaction assay and directly sequenced. Results The IL-1R1 variant rs2234651 was found to be associated with both CAD risk and severity (the degree of exhibited vascular stenosis/number of affected vessels, P = 0.034; Gensini scoring, P = 0.006). Furthermore, significant increase of IL-8 and IL-11 in patients carrying the CT+TT genotype was observed. Finally, serum CD121a levels significantly increased in patients with CAD that harbored the CT+TT genotype ( P <0.05). Conclusions These results demonstrate that the IL-1R1 variant rs2234651 is significantly associated with CAD risk and severity in the analyzed Chinese-Han population and rs2234651 may be a valuable target for CAD prevention and/or treatment.
Is menopause still evolving? Evidence from a longitudinal study of multiethnic populations and its relevance to women’s health
Authors: Chan Shirley , Gomes Alyssa , Singh Rama Shankar 
Published: March 2020

Abstract
To reflect on the impact of changing patterns of delayed marriage and reproduction and to seek evidence as to whether menopause is still evolving, characteristics of the menopause transition were investigated within and between ethnic populations in this study. A cross-sectional analysis was conducted using data on 747 middle-aged women obtained from the Study of Women’s Health Across the Nation (SWAN) from 1996 to 2008. The ethnic groups included: Afro-American, Chinese, Japanese, Caucasian, and Hispanic. Perimenopause age and duration, menopause age, and hormonal indicators of menopause were examined across five ethnicities. We found a similar window of menopause age within populations, but no significant difference in perimenopause and menopause age between populations. The rate of increase of follicle-stimulating hormone and testosterone differed significantly in Hispanics and African-Americans during the menopause transition period. The broad window of variation in age at menopause within the population (45-60 years) and the absence of significant differences between populations, in combination with population variation in menopause symptoms, suggest that menopause is a relatively recently evolved and still evolving trait. Under the mate choice theory of menopause, menopause is the result of the accumulation of infertility mutations in older women due to men’s preference for younger mates. We propose a shifting mate choice-shifting menopause model which posits that, as the age of mate choice/marriage shifts to older age, so will the age at menopause, and that menopause is a transient phase of female fertility; it can de-evolve, be delayed, if not disappear completely. Integrated longitudinal menopausal studies linked with genomics and hormonal studies on diverse ethnic populations can provide valuable information bearing on women’s health and personalized medicine.