bluuebunny/crossref_metadata_2025_split huggingface dataset:
Severe Psychopathology and Substance Use Disorder Modify the Association between Housing Trajectories and Food Security among Homeless Adults
Authors: Lachaud James , Mejia-Lancheros Cilia , Wang Ri , Liu Michael , Nisenbaum Rosane , Stergiopoulos Vicky , Hwang Stephen Wesley , O'Campo Patricia 
Published: May 2020

Abstract
Background We examined the housing trajectories of homeless people with mental illness over a follow-up period of 6 years, and the association of these trajectories with food security. We then examined the modifying role of psychopathology and alcohol and substance use disorders in this association.Methods We followed 487 homeless adults with mental illness at the Toronto site of the At Home/Chez-Soi project –a randomized trial of Housing First. Housing data were collected every 3 months (Phase I) or 6 months (Phase II) during follow-up. Food security data were collected 7 times during the follow-up period. Psychopathology (Colorado Symptom Index score) and alcohol and substance use disorders were assessed at baseline. Housing trajectories were identified using group-based trajectory modelling. Logistic regression was used to estimate the association between housing trajectory groups and food security.Results Three housing trajectory groups were identified: a rapid move to consistent stable housing (34.7%), slow and inconsistent housing (52.1%), and never moved to stable housing (13.2%). Individuals included in the rapid move to consistent housing trajectory group had higher odds of remaining food secure compared to those in the never moved to stable housing trajectory group over the follow-up period [AOR 2.9, 95% CI: 1.3–6.6, P-value: 0.009]. However, when interactions were considered, this association was significant among those with moderate psychopathology but not severe psychopathology. Individuals with substance use disorder and in the group never move to stable house group had the lowest food security status.Conclusion Severe psychopathology and substance use disorders modified the association between housing trajectories and food security. Housing interventions need to focus on long term housing stability as well as food security, especially among those with severe psychopathology and substance use disorder.Ethical considerations The Toronto AH/CS study received approval from the St. Michael’s Hospital Research Ethics Board (Canada), and all participants gave informed written consent to participate in the AH/CS study. The AH/CS study is also registered with the International Standard Randomized Control Trial Number Register (ISRCTN42520374).
Stigma and Lack of Social Support Contribute to Loss-To-Follow-Up in a Cervical Cancer Prevention Program in Western Kenya
Authors: Novak Carissa , Kaiser Bonnie , Park Lawrence , Yvonne Sandra , Ibrahim Saduma , Makhulo Breandan , Huchko Megan 
Published: May 2020

Abstract
Background

While highly preventable, cervical cancer remains a leading contributor to the global burden of cancer among women globally, with disproportionate impacts in Sub-Saharan Africa. Human papillomavirus (HPV) testing is a cost-effective screening strategy with the potential to increase screening uptake; however, the two-visit requirement often leads to substantial loss-to-follow-up (LTFU) for treatment. Understanding modifiable factors that contribute to LTFU is essential to ensuring maximal program impact.
Methods

We carried out a mixed-methods study to understand factors related to LTFU following an HPV-based cervical cancer screening campaign in rural Western Kenya. We randomly selected participants among women testing HPV positive as part of an existing intervention study to complete quantitative surveys, seeking equal numbers of treated and LTFU women. A subset of women from both groups was selected for in-depth interviews (IDIs).
Results

Sixty-one treated and 39 LTFU women completed the quantitative survey, and 10 women from each group completed IDIs. Cost of transportation and distance to the hospital were barriers among all women, who often depended on their partners to facilitate this. Among treated women 67% (n = 41) reported that their peers knew their HPV test result, compared to 38% (n = 15) among LTFU women (p = .007). Stigma and lack of partner and peer support emerged as strong barriers among LTFU women. Women proposed peer encouragement, including men in educational sessions, bringing facilities closer, and providing transportation as facilitators to treatment access.
Conclusion

Lack of partner and social support emerged as key barriers to treatment uptake among LTFU women. Future interventions should explore stigma reduction, male involvement, peer support, and alternative transportation options as potential facilitators to treatment seeking.
Unrevealing Model Compounds of Soil Conditioners Impacts on the Wheat Straw Autohydrolysis Efficiency and Enzymatic Hydrolysis
Authors: Wu Xinxing , Tang Wei , Huang Chen , Huang Caoxing , Lai Chenhuan , Yong Qiang 
Published: May 2020

Abstract
Background: Soil-derived exogenous ash (EA) poses a challenge toward lignocellulosics autohydrolysis due to its buffering capacity. Previous works focusing on this phenomenon have failed to also investigate the role that soluble salts, and organic matter plays in this system. Herein, sodium phosphate and sodium humate were employed as model buffering compounds representing soluble salts and organic matter and dosed into a de-ashed wheat straw (DWS) autohydrolysis process to show the potential impacts of WS attached soil conditioners on the WS autohydrolysis efficiency which would further affect the enzymatic digestibility of autohydrolyzed WS.Results: Results showed that with the increasing loadings of sodium phosphate and sodium humate resulted in elevated pH values (from 4.0 to 5.1 and from 4.1 to 4.7, respectively). Meanwhile, the reductions of xylan removal yields from ~ 84.3–61.4% to 72.3–53.0% by loading (1 ~ 30 g/L) sodium phosphate and sodium humate during WS autohydrolysis lead to a significant decrease of cellulose accessibilities which finally lead to a reduction of the enzymatic digestibility of autohydrolyzed WS from ~ 75.4–77.2% to 47.3–57.7%.Conclusion: The existence of different types soil conditioner model compounds result in various component fractions from autohydrolyzed WS in the process of autohydrolysis. A lack of sufficient xylan removal was found to drive the significant decrease in enzymatic accessibility. The results demonstrated the various effects of two typical tested soil conditioners on WS autohydrolysis and enzymatic hydrolysis.
Effect of adding a psychological intervention to routine care of common mental disorders in a specialized mental healthcare facility in Pakistan: a randomized controlled trial
Authors: Hamdani Syed Usman , Huma Zill-e- , Masood Aqsa , Zhou Kiana , Ahmed Zainab , Nazir Huma , Amin Hania , Akhtar Parveen , Bryant Richard , Dawson Katie , Ommeren Mark van , Wang Duolao , Rahman Atif , Minhas Fareed Aslam 
Published: May 2020

Abstract
Background In many low resource settings, the provision of government mental health care services is limited to specialized psychiatry units in urban hospital care facilities, where the most common treatment for common mental disorders (CMDs) is pharmacotherapy, occasionally with adjunct nonspecific psychological support. We aimed to evaluate the effectiveness of adding a low intensity, psychological intervention, Problem Management Plus (PM+) for CMDs into routine care in a specialized mental health care facility in Pakistan. Methods A two arm, single-blind individual randomized controlled trial (RCT) was carried out with adults (N=192), referred for psychological support by psychiatrists. The study participants were randomized (1:1) to PM+ plus Treatment as Usual (TAU) (n = 96) or TAU only (n = 96). The primary outcomes were symptoms of anxiety and depression, measured by the Hospital Anxiety and Depression Scale (HADS) and functional impairment as measured by WHO Disability Assessment Schedule (WHODAS-12) at 20-weeks after baseline. Results The analysis was done on intention-to-treat principle. The linear mixed model analysis showed that at 20-weeks after baseline, there was a significant reduction in symptoms of anxiety and depression (mean [SD], 16.23 [8.81] vs 19.79 [7.77]; AMD, -3.10; 95% CI, −0.26 to −5.76); p =0.03 and improvement in functioning (mean [SD], 22.94 [9.37] vs 27.37 [8.36]; AMD, -4.35; 95% CI, -1.45 to -7.24); p =0.004 in PM+ plus TAU versus TAU group. The follow-up rate was 67% at primary end-point. Conclusions Specialized care facilities in LMICs may consider adding brief, evidence-based psychological treatments for CMDs to their routine care.
Correction of immunosuppression in aged septic rats by human ghrelin and growth hormone through the vagus nerve-dependent inhibition of TGF-β production
Authors: Zhou Mian , Aziz Monowar , Ochani Mahander , Wang Ping 
Published: May 2020

Abstract
Background: Co-administration of human ghrelin and growth hormone (GH) reverse immunesuppression in septic aged animals, but the mechanism remains elusive. Here we hypothesize that ghrelin and GH co-treatment restores immune response in aged septic rats by inhibiting the production of transforming growth factor-β (TGF-β), an immunoregulatory cytokine through the vagus nerve.Methods: Male aged Fischer rats (22-23-month-old) were made septic by cecal ligation and puncture (CLP) with or without dissecting the vagus nerve (vagotomy). Human ghrelin and GH or vehicle (PBS) were administrated subcutaneously at 5 h post CLP. After 20 h of CLP, serum and spleens were harvested.Results: Serum TGF-β levels were increased in septic aged rats, while ghrelin and GH treatment significantly reduced its levels. Expression of TGF-β in the spleen was upregulated after sepsis, while ghrelin and GH treatment significantly inhibited its expression. TNF-α and IL-6 levels were significantly reduced after ex vivo LPS stimulation in splenocytes of CLP rats compared to sham rats, while these levels were significantly higher in splenocytes from ghrelin and GH-treated CLP rats compared to vehicle-treated CLP rats. Ghrelin and GH treatment reduced program death receptor-1 (PD-1) expression increased human leukocyte antigen (HLA) expression, attenuated lymphopenia and cleaved caspase-3 levels in splenocytes in septic aged rats. Vagotomy diminished those beneficial effects of ghrelin and GH treatment to sepsis rats. In vitro addition of ghrelin or GH or ghrelin and GH together had no effect on restoring immune response in splenocytes from CLP rats following LPS stimulation, indicating the requirement of the vagus nerve for ghrelin and GH’s effect.Conclusions: Ghrelin and GH attenuates immunosuppression in aged septic rats through the vagus nerve-dependent inhibition of TGF-β production.
Revision Surgery for Instrumentation Failure after Total En Bloc Spondylectomy: A Retrospective Case Series
Authors: Shinmura Kazuya , Kato Satoshi , Demura Satoru , Yokogawa Noriaki , Yonezawa Noritaka , Shimizu Takaki , Oku Norihiro , Kitagawa Ryo , Handa Makoto , Annen Ryohei , Murakami Hideki , Tsuchiya Hiroyuki 
Published: May 2020

Abstract
Background:There have been several reports of instrumentation failure after 3-column resections such as total en bloc spondylectomy (TES) for spinal tumours; nevertheless, clinical outcomes of revision surgery for instrumentation failure after TES are seldom reported. Therefore, this study assessed the clinical outcomes of revision surgery for instrumentation failure after TES.Methods:This study employed a retrospective case series in a single centre and included 61 patients with spinal tumours who underwent TES between 2010 and 2015 and followed for >2 years. Instrumentation failure rate, back pain, neurological deterioration, ambulatory status, operation time, blood loss, complications, bone fusion after revision surgery, and re-instrumentation failure were assessed. Data were collected on back pain, neurological deterioration, ambulatory status, and management for patients with instrumentation failure, and we documented radiological bone fusion and re-instrumentation failure in cases followed for >2 years after revision surgery.Results:Of the 61 patients, 26 (42.6%) experienced instrumentation failure at an average of 32 (range, 11−92) months after TES. Of these, 23 underwent revision surgery. The average operation time and intraoperative blood loss were 204 min and 97 ml, respectively. Including the six patients who were unable to walk after instrumentation failure, all patients were able to walk after revision surgery. Perioperative complications of reoperation were surgical site infection (n = 2) and delayed wound healing (n = 1). At the final follow-up, bone fusion was observed in all patients. No re-instrumentation failure was recorded.Conclusion:Bone fusion was achieved by revision surgery using the posterior approach alone.
Deep Learning-Based Question Answering System for Intelligent Humanoid Robot
Authors: Budiharto Widodo , Andreas Vincent , Gunawan Alexander Agung Santoso 
Published: May 2020

Abstract
The development of intelligent Humanoid Robot focuses on question answering systems to be able to interact with people is very rare. In this research, we would like to propose a Humanoid Robot with the self-learning capability for accepting and giving a response from people based on Deep Learning and big data from the internet. This kind of robot can be used widely in hotels, universities and public services. The Humanoid Robot should consider the style of questions and conclude the answer through conversation between robot and user. In our scenario, the robot will detect the user’s face and accept commands from the user to do an action, where the question from the user will be processed using deep learning, and the result will be compared with knowledge on the system. We proposed our deep learning approach, based on use GRU/LSTM, CNN and BiDAF with big data SQuAD as training dataset. Our experiment indicates that using GRU/LSTM encoder with BiDAF gives higher Exact Match and F1 Score, than CNN with the BiDAF model.
Association between lower serum sodium levels and clinical outcomes in insomnia patients
Authors: Bae Eunjin , Lee Tae Won , Jang Ha Nee , Cho Hyun Seop , Chang Se-Ho , Park Dong Jun 
Published: May 2020

Abstract
Background The association of lower serum sodium levels with clinical outcomes in insomnia patients remains unclear. We explored whether lower serum sodium is associated with poor clinical outcomes in patients with insomnia. Methods We retrospectively enrolled patients with a diagnosis of insomnia from January 2011 to December 2012. We divided participants into three groups according to initial serum sodium level: tertile 1 (< 138 mmol/L), tertile 2 (138.0–140.9 mmol/L), and tertile 3 (≥ 141.0 mmol/L). To calculate the relative risk of death, hazard ratios (HRs) and 95% confidence intervals (CIs) were obtained using Cox proportional hazard models. Result A total of 412 patients with insomnia were included, of whom 13.6% (n = 56) had hyponatremia. Patients with lower serum sodium concentrations were older and had lower hemoglobin, calcium, phosphorus, and albumin levels. At the median follow-up of 49.4 months, 44 patients had died and 62 experienced acute kidney injury (AKI). Kaplan-Meier analysis showed significantly higher mortality in patients in the lowest tertile for serum sodium. Lowest tertile of serum sodium, AKI, and chronic respiratory disease were associated with all-cause mortality. In addition, lowest tertile of serum sodium was also significantly associated with AKI. Conclusions The lowest tertile of serum sodium was associated with a higher mortality and AKI rate in insomnia patients. Our results suggest serum sodium level could be used one of the prognostic factor in insomniacs and physicians should be careful to take care of them when they present lower sodium level.
Microenvironmental changes by placenta-derived mesenchymal stem cells restore the ovarian function in ovariectomized rat via activated PI3K-FOXO3 pathway
Authors: Choi Jong Ho , Seok Jin , Lim Seung Mook , Kim Tae Hee , Kim Gi Jin 
Published: May 2020

Abstract
Background: Translational studies have explored the therapeutic potential and feasibility of mesenchymal stem cells (MSCs) in several degenerative diseases; however, the mechanistic studies of the function of these cells have been insufficient. As ovarian failures cause anovulation as well as ovarian steroid hormonal unbalances, the specific aims of this study were to analyze the therapeutic role of placenta derived MSCs (PD-MSCs) in an ovarian-failure ovariectomy (OVX) rat model and evaluate whether PD-MSCs transplantation (Tx) improved folliculogenesis and oocyte maturation in the injured ovary through PI3K/Akt and FOXO signaling. Methods: Blood and ovary tissue were collected and analyzed after various PD-MSCs Tx treatments in the ovariectomized rat model. Changes in the expression of folliculogenesis and ovary regeneration-related genes due to PD-MSCs treatments were analyzed by qRT-PCR, Western blotting, and histological analysis. Results: The levels of hormones related to ovary function were significantly increased in the PD-MSCs Tx groups compared with those of the non-transplantation group (NTx). The follicle numbers in the ovarian tissues were increased along with increased expression of genes related to folliculogenesis for PD-MSCs Tx compared with NTx groups. Furthermore, PD-MSCs Tx induced maturation of follicles by increasing the phosphorylation of GSK3 beta and FOXO3 (p<0.05) and shifting the balance of growth and apoptosis in the oocytes. Conclusions: Taken together, PD-MSCs Tx can restore the ovarian function as well as induce ovarian folliculogenesis via the PI3K/Akt and FOXO signaling pathway.
The psychological impact of COVID-19 on medical care workers in China
Authors: Si Mingyu , Su Xiaoyou , Jiang Yu , Wang Wenjun , Gu Xiao-fen , Ma Li , Li Jing , Zhang Shaokai , Ren Ze-Fang , Liu Yuanli , Qiao Youlin 
Published: May 2020

Abstract
Background Medical care workers experienced unprecedented levels of workload and pressure since the outbreak of COVID-19 started from the end of 2019. Little is known about its exact impact on medical care workers and related factors in China. This study aims to identify the psychological impact of COVID-19 on medical care workers in China.Methods From February 23th to March 5th, 2020, a cross-sectional survey was conducted among 863 medical care workers from 7 provinces in China using standard questionnaires measuring adverse psychological outcomes including Impact of Event Scale-6 (IES-6), Depression, Anxiety and Stress Scale（DASS）and related psychosocial factors like perceived threat, social support and coping strategies. Exploratory Factor analysis was performed to identify the dimensions of perceived threat by study participants. Multivariate regression was used to examine the determinants of adverse psychological outcomes. Results Posttraumatic stress (PTS) were prevalent in this sample of health care professionals, and 40.2% indicated positive screens for significant posttraumatic stress disorder (PTSD) symptoms. The proportion of having mild to extremely severe symptoms of depression, anxiety and stress were 13.6%, 13.9% and 8.6%, respectively. Perceived threat and passive coping strategies were positively correlated to PTS and DASS scores, while perceived social support and active coping strategies were negatively correlated to DASS scores. Nurses were more likely to be anxious than others among medical care workers during the COVID-19 epidemic. Conclusions Adverse psychological symptoms were prevalent among medical care workers in China during the COVID-19 epidemic. Screening for adverse psychological outcomes and developing corresponding preventive measures would be beneficial in decreasing negative psychological outcomes.
Pretreatment Clamping of Pulmonary Artery During Uniportal Thoracoscopic
Authors: Zhang Ruijie , Cai Yixin , Wang Tiffany , Fu Xiangning , Zhang Ni 
Published: May 2020

Abstract
Background
Intraoperative pulmonary artery (PA) hemorrhage is one of the leading reasons for conversion from uniportal VATS to open thoracotomy ,especially for the small incision (≤ 3 cm) uniportal VATS performed by our department. So, We designed a technology called pretreatment clamping of the pulmonary artery,which may be helpful to solve the problem.
Methods
A retrospective analysis of 19 patients who had pulmonary artery bleeding during uniportal thoracoscopic lobectomy in which one group had undergone preventive pulmonary artery clamping, the clamping group (n = 11), and one group which did not receive preventive clamping, the non-clamping group (n = 8). We compared the rates of conversion from the uniportal VATS approach to open thoracotomy or multi-incision operation, duration of pulmonary artery repair, blood loss, length of postoperative hospital stay and postoperative complications of the two groups.
Results
Compared to the non-clamping group, the clamping group had lower rates of conversion to open thoracotomy (0% vs 62.5%, p < 0.05) and lower rates of conversion to multi-incision operations (18.2% of non-clamping converted to 2-port approach vs 12.5% of clamping converted to 2-port approach and 12.5% converted to 3-port approach, p < 0.05). Duration of pulmonary artery repair was reduced in the clamping group (10.1 ± 3.2 min vs 18.3 ± 5.5 min, p < 0.05). The clamping group also had decreased blood loss (23.6 ± 11.2 ml vs 47.5 ± 14.9 ml, p༜0.05). There were no significant differences in postoperative hospital stay and postoperative complications between the two groups.
Conclusion
Pretreatment clamping of the pulmonary artery in VATS lobectomy can decrease conversion rates, decrease blood loss, shorten repairing time of the pulmonary artery, and feasibly can be applied in uniportal thoracoscopic lobectomy.