bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive factors for arteriovenous fistula maturation: A prospective study
Authors: Correia Ana Luisa , Silva Ana Rita , Mira Filipe , Pinto Rui , Ferreira Emanuel , Guedes Marques Maria , Romãozinho Catarina , Alves Rui 
Published: December 2024

AbstractIntroductionArteriovenous fistula (AVF) maturation failure remains common despite preoperative ultrasound mapping. Identifying predictive biomarkers can help anticipate primary failure and reducing invasive procedures. Our study aimed to identify clinical and analytical risk factors for primary AVF failure or delay.MethodsA prospective study (October 2022–March 2023) included adult patients scheduled for AVF creation. In all patients, a preoperative ultrasound mapping was conducted and AVF maturation assessed at least 6 weeks post‐surgery. Clinical, analytical, and demographic data were collected.FindingsEighty patients were included, 62.5% male, and mean age 66.3 years. For distal anastomosis, preoperative vein (3.8 ± 1.2 vs. 2.8 ± 0.6 mm; p 0.002) and supply artery (2.5 ± 0.4 vs. 2.0 ± 0.3 mm; p 0.001) diameters were significant factors impacting primary failure. Also, for proximal anastomosis, the artery diameter (2.4 ± 0.4 vs. 2.0 ± 0.4 mm; p 0.01) had an impact on AVF maturation. ROC curves established for distal AVF a vein diameter cutoff of 3.25 mm (AUC 77.2%) and artery cut‐off of 2.35 mm (AUC 74.6%) and for proximal AVF an artery cutoff of 2.25 mm (AUC 76.5%). Distal AVF creation correlated with higher primary failure risk (p < 0.001). No correlation was found between the primary failure rate and the presence of central venous catheter or serum results. In a sub analysis, we found that patients with central venous catheter had higher levels of inflammatory markers.DiscussionOur study highlights the importance of preoperative evaluation, ultrasound mapping, and careful AVF site selection. Recognizing vein and artery diameter thresholds for optimal outcomes is crucial. Avoiding central venous catheters in suitable patients can positively impact AVF results.
The Role of Community Social Capital and Collective Action in the Development of Sustainable Tourism
Authors: Auliah Aidha , Prayitno Gunawan , Ari Ismu Rini Dwi , Adrianto Dimas Wisnu , Subagiyo Aris , Biloshkurska N. V. , Ismaili Hairi 
Published: December 2024

ABSTRACTBangelan Tourism Village in Indonesia holds significant potential as a tourist destination that delivers both economic and social benefits to the local community. This study focuses on the role of social capital as a key factor in the success of sustainable tourism development. The theoretical framework of this research centres on social capital, which includes trust, social networks and norms as essential elements that facilitate collective action between communities and the government to achieve sustainable tourism. Social capital, in its connection to sustainable tourism, enables coordination and collaboration among local stakeholders to pursue common goals. Uniquely, this study demonstrates that community‐driven collective action, supported by social capital, is more effective than government‐initiated programmes in advancing sustainable tourism in rural Indonesia, filling a gap in the existing literature. Data were collected via questionnaires from 261 heads of households in Bangelan Tourism Village and analysed using the structural equation modelling (SEM) partial least square (PLS) method. The results indicate that social capital, represented by trust, social networks and norms, has a strong positive influence on collective action. In turn, collective action has an even stronger impact on achieving sustainable tourism. The practical implications underscore the importance of strengthening social capital to promote active community participation in tourism management, through strategies such as community training and policies that foster mutual cooperation. This research provides a significant contribution to the literature on the relationship between social capital, collective action and sustainable tourism development, offering valuable insights for policymakers seeking to strengthen social capital in support of sustainable rural tourism.
DExD‐Box Helicase 21 Enhances Myometrial Contractions Through Thrombospondin‐1‐Mediated Increase in Cell Adhesion
Authors: Chen Lina , Jiang Yanmin , Wang Xiaodi , Wang Lele , Bao Junjie , Lv Zi , Sha Xiaoyan , Zheng Zheng , Chen Yunshan , Ji Kaiyuan , Liu Huishu 
Published: December 2024

ABSTRACTDuring labour, the myometrium transitions from a quiescent to an actively contracting state, governed by changes in gene expression. Identifying the pivotal transcription regulators involved in these gene expression alterations offers a useful strategy for addressing abnormal myometrial contractions. This study determined that the transcriptional regulator DExD‐Box Helicase 21 (DDX21) is upregulated in human myometrial tissues and myometrial smooth muscle cells (hMSMCs) during labour. DDX21 enhances hMSMC contractility through a mechanism that involves binding to thrombospondin 1 (THBS1) mRNA, a cell adhesion molecule, and promoting its transcription and subsequent protein expression. This upregulation of THBS1 increases cellular adhesion, which is crucial for effective myometrial contraction and for contractile function. Consequently, the DDX21‐THBS1 pathway could be a potential target for modulating key functions required for effective myometrial contraction.
Do meaningful dimensions of childhood adversity exist? Data‐driven evidence from two prospective cohort studies
Authors: Chow Athena R.W. , Baldwin Jessie R. , Bowes Lucy 
Published: December 2024

BackgroundThere is not yet a consensus on the best way to conceptualise adverse childhood experiences (ACEs). We used data‐driven methods across two populations to examine (a) if there were meaningful dimensions underlying ACEs and (b) whether dimensions were differentially associated with increased risk of adolescent psychopathology.MethodsParticipants were 18,539 British children from the UK Millennium Cohort Study (MCS) and 11,876 American children from the US Adolescent Brain Cognitive Development Study (ABCD). A wide range of ACEs (e.g., abuse, neglect, parental psychopathology, peer victimisation) were measured prospectively from infancy to mid‐adolescence using interviews and questionnaires. Internalising and externalising symptoms were assessed with child and/or parent reports during adolescence.ResultsOur preregistered exploratory factor analysis revealed four latent dimensions in the MCS (parental threat, deprivation, victimisation, and parental discipline) and ABCD (parental threat, deprivation, victimisation, and traumatic events). All dimensions except deprivation were associated with increased risk for internalising and externalising symptoms. Over and above the other dimensions, victimisation was more strongly associated with internalising (MCS β = .34, 95% CI 0.33–0.36; ABCD β = .11, 95% CI 0.10–0.13) and externalising (MCS β = .31, 95% CI 0.30–0.33; ABCD β = .13, 95% CI 0.11–0.15) symptoms.ConclusionsAcross two distinct populations, we found that ACEs can be captured by common underlying dimensions of parental threat, deprivation, and victimisation, as well as additional sample‐specific dimensions. Our findings expand dimensional theories of childhood adversity by suggesting that in addition to threat and deprivation, victimisation is a distinct dimension of adversity that has the strongest associations with adolescent psychopathology.
How smart is smart money? Evidence from mutual funds' exposure on corporate misconduct
Authors: Kong Dongmin , Zhao Zhao 
Published: December 2024

AbstractWe examine how mutual funds' trading and performance respond to corporate misconduct. We exploit a combined dataset of corporate misconduct and holding information of mutual funds and find that mutual funds tend to not only sell but also buy more stocks of corporations with misconduct. Moreover, the exposure to misconduct stocks is negatively related to mutual funds' future performance. The top quintile portfolio of funds with the highest level of misconduct exposure underperforms the bottom quintile by 1.57% to 1.97% on an annualized basis. This performance gap is wider when it is easier for fund managers to gain information advantages.
Clinical Significance of Lymphatic Involvement in Intramucosal (pT1a) Gastric Cancer Resected by Endoscopic Submucosal Dissection
Authors: Matsueda Katsunori , Kono Yoshiyasu , Miyahara Koji , Nakagawa Masahiro , Mouri Hirokazu , Matsueda Kazuhiro , Hamada Kenta , Iwamuro Masaya , Kawano Seiji , Kawahara Yoshiro , Tanaka Takehiro , Otsuka Motoyuki 
Published: December 2024

ABSTRACTBackground and AimLymphatic involvement is sometimes detected during routine examination of intramucosal (pT1a) gastric cancer resected endoscopically. However, its clinical significance and association with the risk of metastasis remain unknown.MethodsThis was a retrospective cohort study of 6797 consecutive patients with pT1a gastric cancers treated by endoscopic submucosal dissection (ESD) at three institutions in Japan from January 2005 to August 2023. Patients with 49 uncommon‐type gastric cancer types were excluded. The risk of metastasis for pT1a cancers with lymphatic involvement was quantified by comparing lymph node metastasis and/or metastatic recurrence in patient groups who underwent additional surgery post‐ESD or did not undergo surgery but were followed up for > 3 years.ResultsAmong the 6748 pT1a cancers treated by ESD, 41 lesions (0.6%) had histologically confirmed lymphatic involvement. Among the 41 patients, 1 was excluded from the analysis of metastasis risk because the follow‐up period after ESD without additional surgery was ≤ 3 years. Metastasis was identified in 1 of 40 patients analyzed (2.5%; 95% confidence interval [CI] 0.4%–12.9%), and was not detected in any of the 25 patients with pure differentiated‐type lesions (0.0%; 95% CI 0.0%–13.7%).ConclusionsThe low prevalence of metastasis after ESD for pT1a gastric cancer with lymphatic involvement, particularly in patients with pure differentiated‐type lesions, suggests a low risk of metastatic recurrence.
Associations between multimorbidity and kidney function decline in old age: A population‐based cohort study
Authors: Beridze Giorgi , Dai Lu , Carrero Juan‐Jesús , Marengoni Alessandra , Vetrano Davide L. , Calderón‐Larrañaga Amaia 
Published: December 2024

AbstractBackgroundIndividual chronic conditions have been linked to kidney function decline; however, the role of multimorbidity (the presence of ≥2 conditions) and multimorbidity patterns remains unclear.MethodsA total of 3094 individuals from the Swedish National study on Aging and Care in Kungsholmen (SNAC‐K) were followed for 15 years. Multimorbidity was operationalized as the number of chronic conditions and multimorbidity patterns identified using latent class analysis (LCA). Joint models and Cox regression models were used to explore the associations between multimorbidity, and subsequent absolute and relative (≥25% decline from baseline) changes, respectively, in the estimated glomerular filtration rate (eGFR) calculated using the creatinine‐based Berlin Initiative Study equation.ResultsMean age of the sample was 73.9, and 87% had multimorbidity. There was an independent dose–response relationship between the number of chronic conditions, and absolute (β [95% confidence interval, CI] = −0.05 [−0.07; −0.03]) and relative (hazard ratio, HR [95% CI] = 1.23 [1.17; 1.29]) declines in eGFR. Five patterns of multimorbidity were identified. The Unspecific, low burden pattern had the lowest morbidity burden and was used as the reference category. The Unspecific, high burden, and Cardiometabolic patterns showed accelerated absolute (β [95% CI] = −0.15 [−0.26; −0.05] and −0.77 [−0.98; −0.55], respectively) and relative (HR [95% CI] = 1.45 [1.09; 1.92] and 3.45 [2.27; 5.23], respectively) declines. Additionally, the Cognitive and Sensory pattern showed accelerated relative decline (HR [95% CI] = 1.53 [1.02; 2.31]). No associations were found for the Psychiatric and Respiratory pattern.ConclusionMultimorbidity is strongly associated with accelerated kidney function decline in older age. Individuals with cardiometabolic multimorbidity exhibit a particularly increased risk. Increased monitoring and timely interventions may preserve kidney function and reduce cardiovascular risks in individuals presenting with conditions that are characteristic of high‐risk multimorbidity patterns.
Perceptions of Coping With Breastfeeding Pain: A Secondary Analysis
Authors: Russell Megan , Lucas Ruth , Bernier Carney Katherine 
Published: December 2024

IntroductionAlthough there are many known benefits of providing human milk to infants, breastfeeding‐related pain is a significant reason for breastfeeding cessation. Breastfeeding‐related pain is a unique experience due to breastfeeding's goal‐directed purpose, repetitive nature, and socio‐emotional reflections of successful parenting. Understanding how lactating parents cope with breastfeeding‐related pain will inform clinical practice to encourage individuals to meet their lactation goals. The aim of this study was to evaluate how lactating parents view coping with breastfeeding‐related pain to be different from coping with other types of pain.MethodsWe conducted a secondary analysis of a pilot randomized control study of a breastfeeding pain self‐management intervention. Data from 57 participants who breastfed and completed self‐report surveys at 1, 2, and 6 weeks postpartum were included. We employed Boyatzis’ thematic analysis method to evaluate affirmative responses to “Is coping with breastfeeding pain different than coping with other pain?” We evaluated correlations between responses to coping with breastfeeding pain and pain severity scores.ResultsWe identified 3 main themes: (1) uncharted waters, (2) light at the end of the tunnel, and (3) parental role and responsibility. No significant differences were detected between the pain scores of individuals who viewed coping with breastfeeding to be different and those who did not.DiscussionLactating parents reported an array of psychological coping strategies in response to breastfeeding‐related pain. Coping processes were influenced by personal goals, parental role evaluations, and a desire to meet their infant's needs. Interventions during prenatal and postpartum care that incorporate individualized coping strategies could support breastfeeding goal attainment.
Stigmatization and Psychosocial Burden in Acne Patients
Authors: Tunca Mustafa , Balik Zeynep Büşra , Uncu Hüma Beliz , Botsali Ayşenur 
Published: December 2024

ABSTRACTBackgroundAcne vulgaris, a common dermatological condition, has physical manifestations and significant emotional and social implications for those affected. This study aims to assess the stigma experienced by acne vulgaris patients and identify relevant physical, social, and psychological factors.MethodsThe research involved individuals aged 12–45 diagnosed with acne vulgaris. The authors recorded each patient's demographic information, global acne severity, and acne scar severity. Additionally, each patient completed the Dermatologic Life Quality Index, Beck Depression Inventory, Liebowitz Social Anxiety Scale, and 6‐item stigmatization scale. Using the scale scores, the authors categorized the severity into subgroups and compared the results within these subgroups.ResultsThe severity of acne was positively correlated with DLQI scores (r = 0.196, p = 0.004) and stigmatization scores (r = 0.156, p = 0.024). Higher stigmatization scores were associated with increased levels of depression (r = 0.461, p < 0.001) and anxiety (r = 0.336, p < 0.001), as well as a significant impact on quality of life (r = 0.472, p < 0.001). Upon stratification of patients into three age groups (adolescence, late adolescence, and adulthood), the comparisons between these groups did not reach statistical significance.ConclusionThe results of the current study reveal a clear connection between the severity of acne and psychosocial disturbances, irrespective of age. The authors advise incorporating psychosocial screening, especially for severe acne vulgaris patients of all ages.
Factors influencing confidence in tracheal intubation among neonatal trainees: A questionnaire‐based study
Authors: Rao Vishwas , Balachander Bharathi , Dubey Pragya , Rao PN Suman 
Published: December 2024

AimTracheal intubation (TI) is pivotal in managing critically ill neonates. This study aims to investigate the disparities in exposure and training techniques that affect self‐perceived confidence in neonatal fellows concerning TI.MethodsA comprehensive, structured questionnaire‐based survey was conducted among neonatal trainees from October to November 2022. Self‐perceived confidence in TI was evaluated using a Likert scale, ranging from 1 to 10. The trainees who scored below seven were categorised as under‐confident, while those who scored seven or more were considered confident in TI. An analysis was done to assess the differences in exposure, training and clinical policies related to TI in both groups. A P‐value <0.05 was considered significant.ResultsThe final dataset consisted of 93 trainees. Confidence was higher among those who had independently performed TI on more than 30 neonates during their postgraduate training (relative risk (RR) 1.5 (1.03–2.1), P = 0.02) and super‐specialty training (RR 1.5 (1.20–1.93), P = 0.0004). Confidence was also significantly associated with training programmes that incorporated written checklists for intubation instruments and policies (RR 1.4 (1.1–1.8), P = 0.006), conducted debriefing sessions after each TI attempt (RR 1.3 (1.03–1.6), P = 0.005), and implemented regular simulation programmes (RR 1.4 (1.1–1.8), P = 0.0006).ConclusionsTrainees with increased opportunities for intubation and training programmes featuring regular simulations and debriefing sessions tend to possess higher self‐perceived confidence in TI.
Enterobacter mori Causing Leaf Spot and Soft Rot in Three New Ornamental Hosts
Authors: Bolhasani Fatemeh , Falahi Charkhabi Nargues 
Published: December 2024

ABSTRACTLeaf spot and soft rot of ornamental plants were observed in the Alborz and Markazi provinces during the summer and autumn of 2022. Eighteen samples were collected from symptomatic ornamental plants in Karaj and Arak cities. Necrotic leaf spots surrounded by a broad yellow halo were observed in the affected pothos (Epipremnum aureum) and compact dragon (Dracaena compacta) plants. On the severely affected, leaves of compact dragon with a yellow margin were observed. Soft rot symptoms which turned dark brown areas were observed on the diseased jade plants (Crassula ovata). The colonies of bacterial strains were cream‐coloured, round, convex, smooth and with entire margins on nutrient agar. In the pathogenicity of 35 recovered strains, the five strains isolated from pothos caused water‐soaking 2 days after inoculation, which finally turned into necrotic lesions surrounded by chlorotic halos. Eight strains isolated from compact dragon produced necrotic spots on the inoculated plants. Five strains originated from jade plants induced soft rot 4–5 days post‐inoculation. All 18 pathogenic strains were negative in Gram and oxidase reactions. The gyrB and infB gene sequences of eight representative strains were partially amplified and sequenced. In the maximum‐likelihood phylogenetic tree created based on the concatenated sequences of gyrB and infB genes, the strains clustered with Enterobacter mori LMG 25706T supported with bootstrap value of 100%. To the best of our knowledge, this is the first report of pothos and compact dragon leaf spot and jade plant soft rot caused by E. mori.
Recent advancements in aquaponics with special emphasis on its sustainability
Authors: Nair Chythra Somanathan , Manoharan Ramya , Nishanth Drishya , Subramanian Radhakrishnan , Neumann Elke , Jaleel Abdul 
Published: December 2024

AbstractAn aquaponic system which is an integration of hydroponics with aquaculture is sustainable, ecologically friendly, and uses non‐renewable resources with very high efficacy. The increasing trend in aquaponics research demonstrates a growing recognition of its potential to address critical global issues such as food security, water conservation, and sustainable agriculture, particularly in regions vulnerable to climate change and resource limitations. It has witnessed remarkable advancements in recent years, with various methods and variations emerging to enhance its functionality and productivity. The purpose of this review is to unify fragmented research on aquaponics and provide a comprehensive resource that emphasizes its potential for broad adoption and successful implementation in varied environments. This review focuses on recent innovations in aquaponic system designs for various climates and examines key advancements in critical areas, including microbial communities, biofiltration, feed management, water quality, and nutrient cycling, emphasizing the interdisciplinary nature of aquaponics. Coupled systems suit moderate climates with high resource efficiency, while decoupled systems offer flexibility across diverse climates by allowing independent control of each component. Innovations such as sandponics, algaeponics, and saline aquaponics address challenges like water scarcity and nutrient efficiency. Smart technologies like IoT and AI are integrated into aquaponics, automating monitoring and nutrient management for better productivity. Emerging areas, including vermi‐aquaponics and flocponics, offer new solutions for nutrient cycling, making aquaponics more efficient, adaptable, and resource‐conserving globally. This paper also examines the sustainability aspects of aquaponics, emphasizing its economic, social, and environmental dimensions. Despite high setup costs and nutrient complexities, aquaponics offers significant potential for sustainable food production by minimizing water use and reducing synthetic fertilizers. Its scalability in both urban and rural areas, along with innovations like vertical systems, presents promising solutions for enhancing agriculture and food security across diverse environments.
Cognitive Reappraisal Reduces Academic Anxiety in University Students With Dyslexia
Authors: Coates McDowall Holly , Rimfeld Kaili , Krishnan Saloni 
Published: December 2024

ABSTRACTUniversity students with dyslexia have greater anxiety than their peers without dyslexia, especially related to their academic studies. Most universities focus on mitigating the learning needs of these students, for example, providing more time during exams. Relatively little attention is paid to the psychological impact of having dyslexia. In this preregistered study, we investigated whether cognitive reappraisal reduced academic anxiety in university students with dyslexia. We codesigned negative and neutral scenarios about academic life with university students with dyslexia. We presented university students (54 students with dyslexia and 51 neurotypical students) with these scenarios about academic life and asked them to rate their anxiety. As hypothesized, we observed that students with dyslexia had higher academic anxiety than those without dyslexia (d = 0.43). When instructed to use cognitive reappraisal, all students, irrespective of having dyslexia or not, benefitted from an anxiety reduction (d = 0.87). Our experimental research indicates cognitive reappraisal may be a valuable tool to support students. Furthermore, it may help those with dyslexia to manage the heightened emotional demands of academia. Intervention trials that assess the real‐world implementation of cognitive reappraisal are now warranted.