bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding Policy Shift: Class Interests, Exogenous Pressure, and Policy Reform in the Philippines
Authors: Trinidad Dennis D. 
Published: January 2020

The paper is a theoretical discourse on policy shift, defined as the turning point or threshold by which policymaking agents abandon old policy preferences in favor of new ones. It contends that policy shift is contingent upon two factors: (1) the nature of elite interests, and (2) exogenous pressures like world prices and economic crises. The dismantling of cohesive elite interests is essential before policy shift could take place. Exogenous pressures can help achieve this by altering the settings which define these interests.
Specifically, the paper examines the liberalization of trade and investment in the Philippines as an episode of policy shift. In the 1980s, the sudden reversal of international prices of agricultural products forced many agrarian elites to abandon agriculture and shift to other more lucrative business ventures like services and manufacturing. In the process, they explored new areas of interest and formulated corresponding sets of policy preferences. Against this backdrop and under a new constitution, former President Fidel V. Ramos and his successors pursued liberalization. The trend toward further economic liberalization became irreversible due to the country’s commitment to international agreements such as the World Trade Organization, ASEAN Free Trade Area, ASEAN-China Free Trade Agreement and the proposed Philippines-Japan Economic Partnership Agreement.
Finland’s Continuation War (1941–1944): War of Aggression or Defence? War of Alliance or Separate War?
Authors: Hannikainen Lauri 
Published: January 2020

In September 1939, after having included a secret protocol on spheres of influence in the so-called Molotov- Ribbentrop Pact, Germany and the Soviet Union invaded Poland and divided it between themselves. It was not long before the Soviet Union approached Finland by proposing exchanges of certain territories: ‘in our national interest we want to have from you certain territories and offer in exchange territories twice as large but in less crucial areas’. Finland, suspicious of Soviet motives, refused – the outcome was the Soviet war of aggression against Finland by the name of the Winter War in 1939–1940. The Soviet Union won this war and compelled Finland to cede several territories – about 10 per cent of Finland’s area.
After the Winter War, Finland sought protection from Germany against the Soviet Union and decided to rely on Germany. After Germany attacked the Soviet Union in June 1941, Finland joined the German war effort in the so-called Continuation War and reoccupied the territories lost in the Winter War. Finnish forces did not stop at the old border but occupied Eastern (Soviet) Karelia with a desire eventually to annex it. By that measure, Finland joined as Germany’s ally in its war of aggression against the Soviet Union in violation of international law. In their strong reliance on Germany, the Finnish leaders made some very questionable decisions without listening to warnings from Western States about possible negative consequences.
Germany lost its war and so did Finland, which barely avoided entire occupation by the Soviet Army and succeeded in September 1944 in concluding an armistice with the Soviet Union. Finland lost some more territories and was subjected to many obligations and restrictions in the 1947 Paris Peace Treaty, dictated by the Allies.
This article analyses, according to the criteria of international law, Finland’s policy shortly prior to and during the Continuation War, especially Finland’s secret dealings with Germany in the months prior to the German attack against the Soviet Union and Finland’s occupation of Eastern Karelia in the autumn of 1941. After Adolf Hitler declared that Germany was fighting against the Soviet Union together with Finland and Romania, was the Soviet Union entitled – prior to the Finnish attack – to resort to armed force in self-defence against Finland? And was Finland treated too harshly in the aftermath of World War ii? After all, its role as an ally of Germany had been rather limited.
The Rapid Intensification and Eyewall Replacement Cycles of Hurricane Irma (2017)
Authors: Fischer Michael S. , Rogers Robert F. , Reasor Paul D. 
Published: January 2020

Abstract
The initiation of a rapid intensification (RI) event for a tropical cyclone (TC) at major hurricane intensity is a rare event in the North Atlantic basin. This study examined the environmental and vortex-scale processes related to such an RI event observed in Hurricane Irma (2017) using a combination of flight-level and airborne radar aircraft reconnaissance observations, microwave satellite observations, and model environmental analyses. The onset of RI was linked to an increase in sea surface temperatures and ocean heat content toward levels more commonly associated with North Atlantic RI episodes. Remarkably, Irma’s RI event comprised two rapidly evolving eyewall replacement cycle (ERC) episodes that each completed in less than 12 h. The two ERC events displayed different secondary eyewall formation (SEF) mechanisms and vortex evolutions. During the first SEF event, a secondary maximum in ascent and tangential wind was observed at the leading edge of a mesoscale descending inflow jet. During the ensuing ERC event, the primary eyewall weakened and ultimately collapsed, resulting in a brief period of weakening. The second SEF event displayed characteristics consistent with unbalanced boundary layer dynamics. Additionally, it is plausible that both SEF events were affected by the stagnation and axisymmeterization of outward-propagating vortex Rossby waves. During the second ERC event, the TC continued to rapidly intensify, which is a stark contrast to the ERC paradigm described in the literature. The differing ERC evolutions appear linked to the vortex response to changing environmental conditions. The results presented here underscore the utility of frequent aircraft reconnaissance observations for an improved understanding of TC dynamics.
Preliminary clinical outcomes of a short-term low-intensity Early Start Denver Model implemented in the Taiwanese public health system
Authors: Lin Tzu-Ling , Chiang Chung-Hsin , Ho Suk Yin , Wu Hsin-Chi , Wong Ching-Ching 
Published: January 2020

The Early Start Denver Model is an evidence-based, comprehensive naturalistic developmental behavioral intervention. Randomized controlled studies indicate that long-term, high-intensity Early Start Denver Model in home-based settings can positively impact the clinical outcomes of young children with autism spectrum disorder. However, it is difficult to deliver high-intensity early intervention in an under-resourced country such as Taiwan. This study evaluated the effects of implementing the Early Start Denver Model with adaptations (including low intensity, shorter duration, and delivery in general hospitals by multidisciplinary professionals) within the Taiwanese public health system. A pre- and post-intervention study was conducted. Sixteen children with autism spectrum disorder (mean age of 33.5 months) received 6 months of one-on-one Early Start Denver Model intervention (approximately 8 h per week). The children showed significant post-intervention improvements in language and overall cognitive functioning and reduced symptom severity in communication and play. This study suggests that delivering the Early Start Denver Model in community-based hospitals may be an effective intervention, with a wider reach, for young children with autism spectrum disorder in Taiwan. The next steps in Taiwan are to incorporate a control group and assess the long-term effects of the adapted Taiwanese Early Start Denver Model program. Lay Abstract The Early Start Denver Model is a comprehensive naturalistic developmental behavioral intervention for young children with autism spectrum disorder. Rigorous studies indicate that long-term, high-intensity Early Start Denver Model in home-based settings can help young children with autism spectrum disorder have great progress in language, cognitive development, and adaptive skills and reduce overall symptom severity. In accordance with the current limitations in resourcing for early intervention in Taiwan, this study evaluated the effects of implementing the Early Start Denver Model in the Taiwanese public health system with some adaptations, including lower intensity, shorter duration, and delivery in general hospitals. A total of 16 children with autism spectrum disorder, aged between 25 and 46 months, received approximately 8 h per week one-on-one Early Start Denver Model intervention. After 6 months of intervention, the children showed great improvements in language and overall cognitive functioning and reduced symptom severity in communication and play. This study suggests that directly delivering the Early Start Denver Model in community-based hospitals may be an effective intervention, which can make more young children with autism spectrum disorder in Taiwan access the Early Start Denver Model service.
Prevalence of coexisting autoimmune thyroidal diseases in coeliac disease is decreasing
Authors: Castro Patricia Dominguez , Harkin Grace , Hussey Mary , Christopher Brian , Kiat Clifford , Chin Jun Liong , Trimble Valerie , McNamara Deirdre , MacMathuna Padraic , Egan Brian , Ryan Barbara , Kevans David , Abuzakouk Mohamed , Farrell Richard , Feighery Con , Byrnes Valerie , Mahmud Nasir , McManus Ross 
Published: January 2020

BackgroundCoeliac disease (CD) is associated with an increased risk of other immune‐mediated conditions.Aim : To investigate the prevalence of coexistent immune‐mediated diseases in CD patients, and changes in the prevalence of autoimmune thyroidal diseases over the last 50 years.MethodsMedical record data were collected retrospectively from 749 CD patients in Ireland. Prevalence of autoimmune diseases was compared with previously published results from general populations. Patients were divided into four groups based on the year of diagnosis to analyse changes in the prevalence of autoimmune thyroidal disease over time.ResultsMedian age at the time of CD diagnosis was 56 years (range 18–91 years). A total of 233 (31.1%) patients had a coexistent immune‐mediated condition (IMC). Autoimmune thyroidal diseases were seen in 149 (19.9%) patients, hypothyroidism in 110 (14.7%), type 1 diabetes in 27 (3.6%), psoriasis in 20 (2.7%), inflammatory bowel disease in 14 (1.9%) and rheumatoid arthritis in 12 (1.6%). All conditions were more common in CD patients than in the general population. Type 1 diabetes was diagnosed mainly before CD, whereas there was no such trend in other conditions. Autoimmune thyroidal diseases became less common in female CD patients over time.ConclusionsPrevalence of autoimmune diseases is increased in adult CD patients compared with the general population. However, concomitant autoimmune thyroidal diseases became less common over time in women.
Applying evidence-based medicine in general practice: a video-stimulated interview study on workplace-based observation
Authors: Welink Lisanne S. , Van Roy Kaatje , Damoiseaux Roger A. M. J. , Suijker Hilde A. , Pype Peter , de Groot Esther , Bartelink Marie-Louise E. L. 
Published: January 2020

Abstract
Background
Evidence-based medicine (EBM) in general practice involves applying a complex combination of best-available evidence, the patient’s preferences and the general practitioner’s (GP) clinical expertise in decision-making. GPs and GP trainees learn how to apply EBM informally by observing each other’s consultations, as well as through more deliberative forms of workplace-based learning. This study aims to gain insight into workplace-based EBM learning by investigating the extent to which GP supervisors and trainees recognise each other’s EBM behaviour through observation, and by identifying aspects that influence their recognition.

Methods
We conducted a qualitative multicentre study based on video-stimulated recall interviews (VSI) of paired GP supervisors and GP trainees affiliated with GP training institutes in Belgium and the Netherlands. The GP pairs (n = 22) were shown fragments of their own and their partner’s consultations and were asked to elucidate their own EBM considerations and the ones they recognised in their partner’s actions. The interview recordings were transcribed verbatim and analysed with NVivo. By comparing pairs who recognised each other’s considerations well with those who did not, we developed a model describing the aspects that influence the observer’s recognition of an actor’s EBM behaviour.

Results
Overall, there was moderate similarity between an actor’s EBM behaviour and the observer’s recognition of it. Aspects that negatively influence recognition are often observer-related. Observers tend to be judgemental, give unsolicited comments on how they would act themselves and are more concerned with the trainee-supervisor relationship than objective observation. There was less recognition when actors used implicit reasoning, such as mindlines (internalised, collectively reinforced tacit guidelines). Pair-related aspects also played a role: previous discussion of a specific topic or EBM decision-making generally enhanced recognition. Consultation-specific aspects played only a marginal role.

Conclusions
GP trainees and supervisors do not fully recognise EBM behaviour through observing each other’s consultations. To improve recognition of EBM behaviour and thus benefit from informal observational learning, observers need to be aware of automatic judgements that they make. Creating explicit learning moments in which EBM decision-making is discussed, can improve shared knowledge and can also be useful to unveil tacit knowledge derived from mindlines.
Novel deep intronic mutation in the coagulation factor XIII a chain gene leading to unexpected RNA splicing in a patient with factor XIII deficiency
Authors: Deng Jun , Li Dan , Mei Heng , Tang Liang , Wang Hua-fang , Hu Yu 
Published: January 2020

Abstract
Background
Coagulation factor XIII (FXIII) plays an essential role in maintaining hemostasis by crosslinking fibrin. Deficiency in FXIII affects clot stability and increases the risk of severe bleeding. Congenital FXIII deficiency is a rare disease. Recently, we identified a Chinese family with FXIII deficiency and investigated the pathogenesis of congenital FXIII deficiency, contributing non-coding pathogenic variants.

Methods
We performed common tests, coding sequencing by targeted next-generation sequencing (NGS), whole-genome sequencing and splice-sites prediction algorithms. The pathogenesis was investigated via minigene and nonsense-mediated mRNA decay (NMD) by experiments in vitro.

Results
The proband is homozygote for a novel deep intronic c.799-12G > A mutation in the F13A1 gene. Through direct sequencing of the minigenes mRNA, we found 10 bases of intron 6 insert in the mRNA of mutant minigenes mRNA. The relative expression of EGFP-F13A1 was higher by suppression of NMD in vitro. Furthermore, we found the proband with enhanced thrombin generation (TG).

Conclusion
We reported a novel deep intronic c.799-12G > A mutation of F13A1 which produced a new acceptor site and frame shifting during translation introducing a premature termination codon. Our results support the premature termination codon triggered NMD. We need to pay attention to the position of potential alterable splicing sites while counselling and genetic test. The finding of enhanced TG indicated that we should be aware of the risk of thrombosis in patients with FXIII deficiency during replacement therapy.
Chromatin remodeling dysfunction extends the etiological spectrum of schizophrenia: a case report
Authors: Poisson Alice , Chatron Nicolas , Labalme Audrey , Fourneret Pierre , Ville Dorothée , Mathieu Marie Laure , Sanlaville Damien , Demily Caroline , Lesca Gaëtan 
Published: January 2020

Abstract
Background
The role of deleterious copy number variations in schizophrenia is well established while data regarding pathogenic variations remain scarce. We report for the first time a case of schizophrenia in a child with a pathogenic mutation of the chromodomain helicase DNA binding protein 2 (CHD2) gene.

Case presentation
The proband was the second child of unrelated parents. Anxiety and sleep disorders appeared at the age of 10 months. He presented febrile seizures and, at the age of 8, two generalized tonic-clonic seizures. At the age of 10, emotional withdrawal emerged, along with a flat affect, disorganization and paranoid ideation, without seizures. He began to talk and giggle with self. Eventually, the patient presented daily auditory and visual hallucinations. The diagnosis of childhood onset schizophrenia (DSM V) was then evoked. Brain imaging was unremarkable. Wakefulness electroencephalography showed a normal background and some bilateral spike-wave discharges that did not explain the psychosis features. A comparative genomic hybridization array (180 K, Agilent, Santa Clara, CA, USA) revealed an 867-kb 16p13.3 duplication, interpreted as a variant of unknown significance confirmed by a quantitative PCR that also showed its maternal inheritance. Risperidone (1,5 mg per day), led to clinical improvement. At the age of 11, an explosive relapse of epilepsy occurred with daily seizures of various types. The sequencing of a panel for monogenic epileptic disorders and Sanger sequencing revealed a de novo pathogenic heterozygous transition in CHD2 (NM_001271.3: c.4003G > T).

Conclusions
This case underlines that schizophrenia may be, sometimes, underpinned by a Mendelian disease. It addresses the question of systematic genetic investigations in the presence of warning signs such as a childhood onset of the schizophrenia or a resistant epilepsy. It points that, in the absence of pathogenic copy number variation, the investigations should also include a search for pathogenic variations, which means that some of the patients with schizophrenia should benefit from Next Generation Sequencing tools. Last but not least, CHD2 encodes a member of the chromodomain helicase DNA-binding (CHD) family involved in chromatin remodeling. This observation adds schizophrenia to the phenotypic spectrum of chromodomain remodeling disorders, which may lead to innovative therapeutic approaches.
Comparing healthcare cost associated with the use of enzyme-inducing and non-enzyme active antiepileptic drugs in elderly patients with epilepsy in the UK: a long-term retrospective, matched cohort study
Authors: Borghs Simon , Byram Laura , Chan Jane , Dedeken Peter , Logan John , Kiri Victor , Noack-Rink Matthias , Patsalos Philip N. , Thieffry Solène 
Published: January 2020

Abstract
Background
In elderly patients (≥65 years of age) with epilepsy who take medications for comorbid conditions, some antiepileptic drugs (AEDs) may alter the metabolism of other treatments and increase the risk of adverse consequences and healthcare utilisation. This analysis compares healthcare costs associated with enzyme-inducing AEDs (EIAEDs) and non-enzyme active AEDs (nEAAEDs) use in elderly patients with epilepsy.

Methods
This retrospective matched cohort study used the Clinical Practice Research Datalink (CPRD) of UK primary care medical records, linked to the Hospital Episode Statistics (HES) database. Selected patients with epilepsy were ≥ 65 years and prescribed an EIAED or nEAAED between 2001 and 2010 (index) after ≥1 year without AEDs (baseline) and followed until the first occurrence of the following: end of HES data coverage, end of GP registration, or death; practice’s up-to-standard status or addition of an AED belonging to another cohort or discontinuation of the last AED of that cohort. Propensity score matching reduced confounding factor effects between cohorts. Key outcomes included time to cohort treatment failure, time to index AED treatment failure, and direct healthcare costs in 2014 Pound Sterling (£) values.

Results
Overall, 1425 elderly patients were included: 964 with EIAEDs and 461 with nEAAEDs. At baseline, the EIAED cohort was older (mean age, 76.2 vs. 75.1 years) and a higher proportion were male. Baseline direct healthcare costs were similar. After matching (n = 210 each), and over the entire follow-up period, median monthly direct healthcare costs were higher for patients taking EIAEDs than nEAAEDs (£403 vs. £317; p = 0.0150, Mann-Whitney U). Costs were higher for patients remaining in the EIAED cohort after 3 follow-up years. The median time to cohort treatment failure for the EIAED cohort was 1110 days vs. 1175 days for the nEAAED cohort.

Conclusion
Newly treated elderly patients with epilepsy were more likely to be prescribed EIAEDs than nEAAEDs. In matched cohorts, elderly patients with epilepsy treated with EIAEDs had higher average total direct and epilepsy-related healthcare costs than nEAAED-treated patients; this difference was greater than previously reported in the overall adult population. Changing treatment practices could improve patient care and reduce costs.
Venous sinus stenting improves cerebral autoregulation in a patient with venous sinus stenosis: a case report
Authors: Jia Meiyan , Guo Zhen-Ni , Jin Hang , Yan Xiuli , Shi Mingchao , Sun Xin , Ma Hongyin , Lv Shan , Yang Yi 
Published: January 2020

Abstract
Background
Venous sinus stenosis (VSS) is a type of cerebral venous vascular disease. Cerebral autoregulation is an indicator of cerebral arterial function. The cerebral circulatory system is composed of the venous system and arterial system. Impaired venous function may affect arterial function. Thus, cerebral venous stenosis may influence cerebral autoregulation.

Case presentation
In this case, a 50-year-old woman with transient blindness and headache was admitted to the hospital. The patient was diagnosed with VSS. A stent was placed at the stenosis. The stent released the intravenous pressure and remitted the patient’s symptoms. Measurements of dynamic cerebral autoregulation (dCA) were performed at 3 time points: before stenting, after stenting, and 3 months later. The dCA gradually improved after stenting.

Conclusion
VSS may have an influence on cerebral autoregulation, and effective treatment improves cerebral autoregulation in patients with VSS.