bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiomic model for differentiating parotid pleomorphic adenoma from parotid adenolymphoma based on MRI images
Authors: Song Le-le , Chen Shun-jun , Chen Wang , Shi Zhan , Wang Xiao-dong , Song Li-na , Chen Dian-sen 
Published: July 2020

Abstract
Background: Magnetic resonance imaging (MRI) is used routinely in the clinical management, and we explored the diagnostic value of radiomic signatures based on MRI to distinguish parotid pleomorphic adenoma from parotid adenolymphoma. Methods: The clinical characteristics and images data were retrospectively collected from 252 cases (126 cases in training cohort and 76 patients in verification cohort) in this study. And 429 radiomic features of T1-weighted imaging (T1WI) sequence and 414 radiomic features of T2-weighted imaging (T2WI) were extracted from MRI images. We selected the radiomic features from three sequences (T1WI, T2WI and T1-2WI) by univariate analysis, lasso correlation and spearman correlation. Then we built six quantitative radiological models based on the selected radiomic features using two machine learning methods (multivariable logistic regression, MLR and support vector machine, SVM). We assessed the performance of the six radiomic models, and an ideal radiomic signature was chosen to compare its diagnosis efficacy with that of the clinical model. ﻿Results: The radiomic model based on features of T1-2WI sequence by MLR showed optimal discriminatory (accuracy = 0.87 and 0.86, F-1score = 0.88 and 0.86, Sensitivity= 0.90 and 0.88, Specificity=0.82 and 0.80 positive predictive value=0.86 and 0.84, negative predictive value=0.86 and 0.84 in training and validation cohorts, respectively) and its good calibration was also observed (p>0.05). The area under the receiver operating characteristic curve (AUC) of the T1-2WI radiomic model was significantly better than that of the clinical model for both the training (0.95 vs. 0.74, p=0.000) and validation (0.90 vs. 0.73, p=0.001) cohorts. Conclusions: The radiomic model based on MRI in our study is complementary to the current knowledge of differential diagnosis for parotid pleomorphic adenoma and parotid adenolymphoma.
Quantitative Assessment of Retinal Thickness and Vessel Density Using Optical Coherence Tomography Angiography in Patients with Alzheimer’s Disease and Glaucoma
Authors: Zabel Przemyslaw , Kaluzny Jakub J. , Zabel Katarzyna , Kaluzna Martyna , Lamkowski Aleksander , Jaworski Damian , Makowski Jaroslaw , Kucharski Robert 
Published: July 2020

Abstract
Background
Retinal imaging using optical coherence tomography (OCT) and OCT angiography (OCTA) may serve as an alternative approach to monitoring and diagnosing neurodegenerative diseases such as Alzheimer's disease (AD) and primary open-angle glaucoma (POAG). In this study, we performed direct comparisons of retinal vessel density with the thickness of inner retinal layer (IRL) and outer retinal layer (ORL) in patients with AD and POAG.
Methods
In this cross-sectional study, we analyzed data from 48 eyes of healthy control (HC) participants, 71 eyes of POAG patients, and 49 eyes of AD patients with confirmed presence of fibrillar brain amyloid on positron emission tomography (PET) imaging with florbetapir F 18. Ophthalmic examination included OCT imaging to measure IRL and ORL thickness in the macula and OCTA in the same region for the imaging of vessel density in the superficial vascular plexus (SVP) and deep vascular plexus (DVP) of the retina. A direct comparison of vessels density and retinal layers thickness, which different dynamic ranges, was obtained by normalizing values as percentage losses. Values were adjusted for inter-eye correlation, age, gender, and scan quality, where applicable.
Results
Patients with AD presented significantly greater losses of vascular density in the DVP and ORL thickness compared to POAG (p < 0.001), but percentage losses of vessel density in SVP and IRL thickness were considerable in POAG compared to AD eyes (p < 0.001). Positive associations among presence of AD were observed primarily in outer retina where a 1% decrease of ORL thickness was associated with about 24–29% increase in odds of the presence of AD. According to OCTA measurements, a 1% decrease of vessel density in DVP was positively associated with a 4–9% increase in odds of the presence of AD. In POAG positive associations among presence of disease were observed only in inner retina where 1% loss of IRL thickness and a 1% loss of vessel density in the SVP were positively associated with a 13–23% increase in risk of presence of the disease.
Conclusions
Analysis of ORL thickness and vessel density in DVP could potentially improve diagnostic capabilities and may provide a valuable approach for predicting of AD.
A Quantitative Site-Specific Classification Approach Based on Affinity Propagation Clustering
Authors: Moustafa Sayed , Khan Farhan , Metwaly Mohamed , A.Elawadi Eslam , Al-Arifi Nassir 
Published: July 2020

Abstract
Investigations made to evaluate the site effect characteristics and develop a reliable site classification scheme have received the paramount importance for the planning of urban areas and for a reliable site-specific seismic hazard assessment. This paper presents a new approach for site classification based on affinity propagation (AP) along with a selected set of representative horizontal to vertical spectral ratio (HVSR) curves inside King Saud University (KSU) campus. Measurements of the ambient vibrations were performed to cover the entire campus area by about 307 stations with 20 minutes recording length and sample rate of 128 Hz for each station to satisfy the criteria for reliable and unambiguous HVSR results. Predominant period values were used for identifying of site response and subsequent site classification. Empirical equations from the literature relating frequency of HVSR peak to average shear wave velocity in the upper 30m, commonly used as a proxy for site classification, were found to be unreliable, making site classification difficult. To overcome this problem, Affinity propagation clustering algorithm is used. The obtained results illustrated that microtremors spectral ratios can be remarkably robust tool in determining site effects. The survey results concluded to the preliminary seismic site classification map for the mapped area, which would be useful for future safe design of structures. Finally, the results presented in this study are encouraging prolongation of this type of study in other parts of Saudi Arabia using the microtremors data and site response functions.
Comprehensive analysis of the functions and prognostic significance of RNA-binding proteins in bladder urothelial carcinoma
Authors: Guo Changgang , Shao Ting , Wei Dadong , Wang Zhanhua , Li Mingyang , Jiang Xiling , Bao Guochang 
Published: July 2020

Abstract
Background

Alterations in RNA-binding proteins (RBPs) are reported in various cancer types; however, the role of RBPs in bladder urothelial cancer (BLCA) remains unknown. This study aimed to systematically examine the function and prognostic significance of RBPs in bladder cancer using bioinformatics analyses.
Methods

RNA sequencing and clinical data for BLCA were downloaded from The Cancer Genome Atlas (TCGA) database, and differentially expressed RBPs (DERBPs) between normal and cancer tissues were identified. Protein-protein interaction (PPI) network of DERBPs was established, and enrichment analysis and visualizations were performed. A total of 404 patients with BLCA from TCGA database were randomly divided into training and testing groups. A prognostic model was constructed using the data from training group, and validated in the testing group. Receiver operating characteristic (ROC) curve and survival analysis were performed to explore the prognostic value of the model. A nomogram was established to predict survival in bladder cancer patients. Finally, the verification of prognosis-related hub RBP survival analysis were performed.
Results

A total of 388 DERBPs were identified, including 219 upregulated and 169 downregulated RBPs. All RBPs were screened for prognostic model establishment and 9 RBPs (TRIM71, YTHDC1, DARS2, XPOT, ZNF106, FTO, IPO7, EFTUD2, and CTU1) were regarded as prognosis-related hub RBPs in BLCA. Further analysis revealed worse overall survival (OS) in the high-risk cohort compared to the model-based low-risk cohort. The area under the ROC curve was 0.752 in the training group and 0.701 in the testing group, which confirms the good prediction ability. A nomogram was established according to nine prognosis-related RBPs, which showed well predicting ability for BLCA. BLCA patients with high DARS2, XPOT, ZNF106, FTO, and IPO7 expression (on the contrary, low YTHDC1 and CTU1 expression) were correlated to poor overall survival.
Conclusions

The prognosis-related hub RBPs may be involved in oncogenesis, development, and metastasis of BLCA. Our results will be of great significance in revealing the pathogenesis of BLCA, and developing new therapeutic targets and prognostic molecular markers.
A Smartphone App to Monitor Mood Symptoms in Bipolar Disorder: Development and Usability Study
Authors: Ryan Kelly Ann , Babu Pallavi , Easter Rebecca , Saunders Erika , Lee Andy Jinseok , Klasnja Predrag , Verchinina Lilia , Micol Valerie , Doil Brent , McInnis Melvin G , Kilbourne Amy M 
Published: July 2020

Background
There is considerable scientific interest in finding new and innovative ways to capture rapid fluctuations in functioning within individuals with bipolar disorder (BD), a severe, recurrent mental disorder associated with frequent shifts in symptoms and functioning. The use of smartphones can provide valid and real-world tools for use in measurement-based care and could be used to inform more personalized treatment options for this group, which can improve standard of care.

Objective
We examined the feasibility and usability of a smartphone to capture daily fluctuations in mood within BD and to relate daily self-rated mood to smartphone use behaviors indicative of psychomotor activity or symptoms of the illness.

Methods
Participants were 26 individuals with BD and 12 healthy control individuals who were recruited from the Prechter Longitudinal Study of BD. All were given a smartphone with a custom-built app and prompted twice a day to complete questions of mood for 28 days. The app automatically and unobtrusively collected phone usage data. A poststudy satisfaction survey was also completed.

Results
Our sample showed a very high adherence rate to the daily momentary assessments (91% of the 58 prompts completed). Multivariate mixed effect models showed that an increase in rapid thoughts over time was associated with a decrease in outgoing text messages (β=–.02; P=.04), and an increase in impulsivity self-ratings was related to a decrease in total call duration (β=–.29; P=.02). Participants generally reported positive experiences using the smartphone and completing daily prompts.

Conclusions
Use of mobile technology shows promise as a way to collect important clinical information that can be used to inform treatment decision making and monitor outcomes in a manner that is not overly burdensome to the patient or providers, highlighting its potential use in measurement-based care.
TeleWound Practice Within the Veterans Health Administration: Protocol for a Mixed Methods Program Evaluation
Authors: Etingen Bella , Patrianakos Jamie , Wirth Marissa , Hogan Timothy P , Smith Bridget M , Tarlov Elizabeth , Stroupe Kevin T , Kartje Rebecca , Weaver Frances M 
Published: July 2020

BackgroundChronic wounds, such as pressure injuries and diabetic foot ulcers, are a significant predictor of mortality. Veterans who reside in rural areas often have difficulty accessing care for their wounds. TeleWound Practice (TWP), a coordinated effort to incorporate telehealth into the provision of specialty care for patients with skin wounds, has the potential to increase access to wound care by allowing veterans to receive this care at nearby outpatient clinics or in their homes. The Veterans Health Administration (VA) is championing the rollout of the TWP, starting with regional implementation.ObjectiveThis paper aims to describe the protocol for a mixed-methods program evaluation to assess the implementation and outcomes of TWP in VA.MethodsWe are conducting a mixed-methods evaluation of 4 VA medical centers and their community-based outpatient clinics that are participating in the initial implementation of the TWP. Data will be collected from veterans, VA health care team members, and other key stakeholders (eg, clinical leadership). We will use qualitative methods (ie, semistructured interviews), site visits, and quantitative methods (ie, surveys, national VA administrative databases) to assess the process and reach of TWP implementation and its impact on veterans’ clinical outcomes and travel burdens and costs.ResultsThis program evaluation was funded in October 2019 as a Partnered Evaluation Initiative by the US Department of Veterans Affairs, Diffusion of Excellence Office, and Office of Research and Development, Health Services Research and Development Service, Quality Enhancement Research Initiative Program (PEC 19-310).ConclusionsEvaluation of the TWP will identify barriers and solutions to TeleWound implementation in a small number of sites that can be used to inform successful rollout of the TWP nationally. Our evaluation work will inform future efforts to scale up the TWP across VA and optimize reach of the program to veterans across the nation.International Registered Report Identifier (IRRID)DERR1-10.2196/20139
A REVIEW ON COVID-19-A GLOBAL BATTLE BETWEEN LIFE AND DEATH
Authors: HANGARGEKAR CHITRA B. , QUAZI RUBIYA S. , JOSHI AMOL A. 
Published: July 2020

Currently, the globe is affected by a severe pandemic scenario of COVID-19 infection. The Covid-19 infectious disease is spreading everywhere on the globe particularly in developed countries like China, u. s. Italy, France, Spain, Iran, England, Germany, South Korea, etc. a deadly disease of a unique coronavirus (COVID‐19 or 2019‐CoV) infection has exhibited significant threats to global health, and also the economy. Following an outbreak of pneumonia without a transparent cause within the city of Wuhan in China, a novel strain of coronavirus (2019-nCoV) was detected in December 2019. Coronavirus is called for the spikes that protrude from their membranes just like the sun's corona. In line with WHO, Common signs of infection embrace fever, cold, cough, and respiratory difficulties like dyspnea, pneumonia. Within the absence of treatment for this virus, there's an imperative got to notice various strategies to manage the unfold of disease. It's “Corona time,” however; unfortunately, it's the virus that we tend to speak. In this paper, the origin of the viral infection, the clinical characteristics of Covid-19, etiology, pathogenesis, symptoms treatment and hindrance of Covid-19 are comprehensively detailed. At the time of this writing there are more queries than answers. The aim of our article is to provide a comprehensive understanding of COVID-19 to the peoples, so they'll better understand it and prevent it.
IN VITRO ANTIDIABETIC POTENTIALS OF SIDA ACUTA, ABUTILON INDICUM AND MALVASTRUM COROMANDELIANUM
Authors: DINLAKANONT NANTAPORN , PALANUVEJ CHANIDA , RUANGRUNGSI NIJSIRI 
Published: July 2020

Objective: Starch metabolizing enzyme inhibitors are able to retard postprandial glucose absorption. This study aimed to investigate the in vitro inhibitory activities of alpha-glucosidase and alpha-amylase of three Malvaceous weeds i.e. Sidaacuta Burm. f., Abutilon indicum (Linn.) Sweet and Malvastrumcoromandelianum (Linn.) Garcke.
Methods: The stems, roots and leaves of S. acuta, A. indicum and M. coromandelianum were sequentially extracted in dichloromethane and methanol, respectively. All fractions were tested for the inhibitory activities on yeast alpha-glucosidase, rat intestinal alpha-glucosidase and porcine alpha-amylase. p-Nitrophenyl-α-D-glucopyranoside and 2-chloro-4 nitrophenol-α-D- maltotrioside were used as the substrate for glucosidase and amylase respectively.
Results: The dichloromethane fraction of the roots and stems from A. indicum and dichloromethane as well as methanolic fractions of the stems of M. coromandelianum could inhibit yeast alpha-glucosidase compared to 1-deoxynojirimycin with the IC50 of 0.36, 0.45, 0.48, 0.48 and 0.58 mg/ml respectively. A. indicum root methanolic fraction had the highest inhibitory effect on rat alpha-glucosidase activity compared to 1-deoxynojirimycin with the IC50 of 0.08 and 0.11 mg/ml respectively. M. coromandelianum, the dichloromethane fraction of roots and the methanolic fraction of stems, showed the strongest effect on alpha-amylase inhibition compared to acarbose with the IC50 of 0.07, 0.07 and 2.7 mg/ml, respectively.
Conclusion: S. acuta, A. indicum and M. coromandelianum dichloromethane and methanolic fractions of the root, stem and leaf parts demonstrated an appreciable inhibitory activity on alpha-amylase from porcine, alpha-glucosidase from Saccharomyces cerevisiae and from rat intestine compared to 1-deoxynojirimycin and acarbose.
UV VISIBLE SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION OF DASATINIB IN BULK AND SOLID DOSAGE FORM
Authors: MADUR SAILI , MATOLE VINOD , KALSHETTI MALLINATH 
Published: July 2020

Objective: A new, simple, sensitive, precise, reproducible UV visible spectrophotometric method was developed for the determination of Dasatinib in Tablet dosage form with­­­ methanol.
Methods: The method is based on the formation of a colorlesscomplex. The UV spectrum of Dasatinib in methanol showed maximum wavelength at 248 nm. Beer’s law is valid in the concentration range of 7-35µg/ml. this method was validated for linearity, accuracy, precision, assay, ruggedness and robustness.
Results: The method has demonstrated excellent linearity over the range of 7-35µg/ml with the regression equation y = 0.0332x+0.0633 and regression coefficient i.e. r2= 0.9994moreover, the method was found to be highly sensitive with LOD(1.08µg/ml) and LOQ(3.29µg/ml).
Conclusion: Based on the results the proposed method can be successfully applied for the assay of Dasatinib in various tablet dosage forms.
PERAN PEMERINTAH DALAM MEMAKSIMALKAN MINYAK NILAM
Authors: Akbar Arif 
Published: July 2020

Aceh Patchouli is an export commodity product that has a high value on the global market. In fact, this great potential can increase the income of farmers and will also indirectly have an effect on the economy of the community, but this has not yet happened, many problems have arisen, ranging from rent issues, unilateral monopoly prices to the continuity of patchouli production. Therefore the role of the government as a facilitator for the development of regional potential is very much needed.
Moving on from these problems, this study aims to see how the role can be done by local governments in increasing the selling value of patchouli by using Global Value Chains or GVC glasses. The election of the GVC perspective in seeing this case is certainly inseparable from the swift influence of globalization on the local government that is now happening. The government should be able to capture the current of globalization as an opportunity to improve the people's economy.
MULTICULTURAL UKHUWAH CONCEPT: The Study of Various Signification on Ukhuwah Perspective of Islamic Elite Religion in Pasuruan District
Authors: Syawaludin Makhfud 
Published: July 2020

The purpose of this research is to describe and analyze the meaning and categorization of ukhuwah based on KH. Ahmad Shiddiq, namely Ukhuwwah Islamiyyah, Ukhuwwah Wathaniyyah, and Ukhuwwah Basyariyyah in the perspective of the Islamic elite of Pasuruan Regency. This research is using qualitative methodology with a phenomenological approach, unstructured and open interview data collection methods, moderate participatory observation, and documentation. Furthermore, the analysis and interpretation of data according to Miles and Huberman (1984) through the following steps: a). Data reduction, b). Display data, and c). Conclusion drawing/ verification. For data validity, using triangulation techniques or methods and triangulation of data or sources. This research is important to look for alternative narratives from phenomenon of the politicization of ukhuwah narrow one. This article is the first in discussing the various perspectives of Islamic religious elites in interpreting and implementing ukhuwah and formulating the concept of multicultural ukhuwah.
Rateb Siribee: Spiritualitas dan Solidaritas Religius Masyarakat Pedesaan Aceh
Authors: Nisma Yuza 
Published: July 2020

During this time zikr Majelis is identical to the urban society that has individualist life as well as heavy life pressures. Zikr became a need to treat the spiritual crisis in an urban society. This is different from the rural society in Labuhan Haji which is the people majority work as farmers and fishermen but exists Majelis Zikr named Rateb Siribee. This study aims to discuss the background of Majelis Zikr, the procession, the reason for people to join in Zikr Majelis Rateb Siribee. The results of this research show that the Majelis Zikr Rateb Siribee exists based on the anxiety of Abuya Amran Wali related to a lack of public interest in religion. Currently, Majelis Zikr Rateb Siribee growing when the peoples feel its benefits both in terms of spiritual and in terms of solidarity. This is done with efforts such as holding Rateb Siribee every week, inviting people from other villages or districts. To hold Rateb Siribee on Islamic Day, in the House of Sorrow, the house between the congregation, the mosque to the Pesantren. Thus, Majelis Zikr increasing the value of the spiritual, the serenity of life, and the caring for others

Abstrak
Selama ini majelis zikir identik dengan masyarakat perkotaan yang memiliki kehidupan individualis serta tekanan hidup yang berat. Zikir sudah menjadi kebutuhan masyarakat untuk mengobati krisis kebatinan (spiritual) dalam hiruk pikuk perkotaan. Hal tersebut berbeda dengan masyarakat pedesaan di Labuhan haji yang mayoritas pekerjaan masyarakatnya petani dan nelayan, tetapi eksis sebuah majelis zikir yang diberi nama Rateb Siribee (Zikir Seribu). Penelitian ini bertujuan untuk mengetahui latar belakang kemunculan, prosesi zikir, penyebab ketertarikan masyarakat bergabung dalam Rateb Siribee. Hasil penelitian ini menunjukkan bahwa berdirinya Rateb Siribee di dasari pada kegelisahan Abuya Amran Wali terkait kurangnya minat masyarakat terhadap agama. Saat ini, Rateb Siribee diminati setelah jamaah merasakan manfaatnya baik dari segi spiritual maupun dari segi solidaritas. Hal tersebut dilakukan dengan upaya-upaya seperti mengadakan Rateb Siribee setiap minggu, mengundang jamaah antar Desa, Kecamatan dan Kabupaten, sering melakukan pengajian rutin di balai desa. Mengadakan Rateb Siribee di hari besar Islam, di rumah duka, rumah antar sesama jamaah, masjid hingga pesantren. Sehingga meningkatkan nilai kebatinan, ketenangan hidup, serta kepedulian terhadap sesama semakin terjalin kuat.
Nilai-Nilai Edukatif Dalam Tradisi Ujung: Kajian Etnografi Di Masyarat Boyolali Jawa Tengah
Authors: Haryanto Sigit 
Published: July 2020

Cultural values always exist in the physical form of tradition. One of the traditions that have rich of values is ujung tradition. It is annual event held by most Javanese people. It has a correlation to lebaran fitr. The participants of this tradition are from children to old people. Visiting their parent, relative, and neighbor are compulsory activity. In addition to, they also utter forgiveness each other. The objective of this study is finding the values behind ujung tradition viewed from educative point. Ethnographic study was selected to conduct the research and participant observation was used to collect the data. Then the data were analyzed by using component analysis proposed by Spradlay.The results of the study showed that there five educative values inside the ujung tradition, namely: respect, togetherness, advice, pray, and charity.From this it is understood that ujung tradition is still run well in society due to many educative values that ought to be transferred.