bluuebunny/crossref_metadata_2025_split huggingface dataset:
Standardised patient education in adrenal insufficiency: a prospective multi-centre evaluation
Authors: Burger-Stritt Stephanie , Eff Annemarie , Quinkler Marcus , Kienitz Tina , Stamm Bettina , Willenberg Holger S , Meyer Gesine , Klein Johannes , Reisch Nicole , Droste Michael , Hahner Stefanie 
Published: June 2020

Objective
Patients with adrenal insufficiency (AI) suffer from impaired quality of life and are at risk of adrenal crisis (AC) despite established replacement therapy. Patient education is regarded an important measure for prevention of AC and improvement of AI management. A standardized education programme was elaborated for patients with chronic AI in Germany.

Design
Longitudinal, prospective, questionnaire-based, multi-centre study.

Methods
During 2-h sessions, patients (n = 526) were provided with basic knowledge on AI, equipped with emergency cards and sets and trained in self-injection of hydrocortisone. To evaluate the education programme, patients from eight certified centres completed questionnaires before, immediately after and 6–9 months after training.

Results
399 completed data sets were available for analysis. Questionnaire score-values were significantly higher after patient education, indicating successful knowledge transfer (baseline: 17 ± 7.1 of a maximum score of 29; after training: 23 ± 4.2; P < 0.001), and remained stable over 6–9 months. Female sex, younger age and primary cause of AI were associated with higher baseline scores; after education, age, cause of AI and previous adrenal crisis had a significant main effect on scores. 91% of patients would dare performing self-injection after training, compared to 68% at baseline. An improvement of subjective well-being through participation in the education programme was indicated by 95% of the patients 6–9 months after participation.

Conclusion
Patient group education in chronic AI represents a helpful tool for the guidance of patients, their self-assurance and their knowledge on prevention of adrenal crises. Repeated training and adaptation to specific needs, for example, of older patients is needed.
Glucocorticoids impair HDL-mediated cholesterol efflux besides increased HDL cholesterol concentration: a proof of concept
Authors: Bouillet Benjamin , Gautier Thomas , Denimal Damien , Samson Maxime , Masson David , Pais de Barros Jean Paul , Maquart Guillaume , Xolin Marion , Grosfeld Alexandra , Dalle Héloïse , Vergès Bruno , Moldes Marthe , Fève Bruno 
Published: June 2020

Objective:
Glucocorticoids (GC) are associated with increased cardiovascular morbidity despite increased HDL-C concentration. HDL-mediated cholesterol efflux, a major anti-atherogenic property of HDL particles, is negatively associated with CVD risk. We aimed to determine whether HDL-mediated cholesterol efflux was influenced by GC.

Design:
Prospective, observational study.

Methods:
Lipid parameters, HDL composition, HDL-mediated cholesterol efflux, cholesteryl ester transfer protein, phospholipid transfer protein and lecithin cholesterol acyl-transferase (LCAT) activities were determined in ten patients with giant cell arteritis before and 3 months after GC introduction and in seven control subjects. HDL concentration and composition, HDL-mediated cholesterol efflux and LCAT activity were determined in GC-treated mice.

Results:
In patients, HDL-C concentration was higher after than before treatment GC-treatment (P = 0.002), while HDL-mediated cholesterol efflux was decreased (P = 0.008) and negatively associated with the proportion of cholesteryl ester in HDL (P = 0.04), independently of CRP. As well, in mice, HDL-C level was increased after GC exposure (P = 0.04) and HDL-mediated cholesterol efflux decreased (P = 0.04). GC-treated patients had higher cholesteryl ester content in HDL, higher HDL2-to-HDL3 ratio and higher LCAT activity than before treatment (P = 0.008, P = 0.02 and P = 0.004, respectively).

Conclusions:
We report, for the first time, that in patients with giant cell arteritis and mice treated with GC, HDL-mediated cholesterol efflux was impaired by GC besides an increased HDL-C level. This impaired HDL functionality, possibly related to HDL enrichment in cholesteryl ester, could contribute to the increased CVD risk observed in GC-treated patients. Further studies are needed in larger populations, to further decipher the effect of GC on HDL.
A new small-flowered Cyrtochilum species (Orchidaceae: Oncidiinae) from the Condor mountains in Ecuador
Authors: Dalström Stig , Higgins Wesley 
Published: June 2020

A new small-flowered species of Cyrtochilum from the isolated range of the Condor mountains in Ecuador is described and illustrated with a line drawing and a photograph of the holotype. It shares morphological features with several different-­looking groups of Cyrtochilum, such as the two generitypes of the genus: C. undulatum and C. flexuosum, as well as with plants in the C. myanthum complex. These groups are treated as three separate genera by some (Cyrtochilum, Trigonochilum and Dasyglossum, respectively), but the combination of morphological features seen in our new species brings the groups together into one polymorphic but genetically monophyletic genus.
Key words: Condor, Cyrtochilum, new species, Oncidiinae
Ministerial formation policies of the Northern Theological Seminary of the Uniting Reformed Church in Southern Africa:
Authors: Kgatla ST 
Published: June 2020

This article investigates the theoretical and practical effectiveness of the Uniting Reformed Church in Southern Africa’s (URCSA) ministerial formation of the Northern Synod. The URCSA is part of the Reformed Movement (Calvinism) that was established by the Dutch Reformed Church (DRC) of South Africa that mainly came from the Netherlands to establish itself in South Africa and later established ethnic churches called daughter churches into existence in terms of a racially designed formula. After many years of the Dutch Reformed Church missionary dominance, the URCSA constituted its first synod in 1994 after the demise of apartheid. It was only after this synod that the URCSA through its ministerial formation tried to shake off the legacy of colonial paternalism and repositioned itself to serve its members; however, it fell victim to new ideological trappings. This article is based on a study that traces some basic Reformed practices and how the URCSA Theological Seminary of the Northern Synod dealt or failed to deal with them in its quest for the ideal theological ministerial formation.
Los catálogos humorísticos de las Exposiciones Nacionales de Bellas Artes en el último tercio del siglo XIX.
Authors: Bazán de Huerta Moisés 
Published: June 2020

RESUMEN: Las Exposiciones Nacionales de Bellas Artes son un factor relevante para valorar el arte español contemporáneo. Inauguradas en 1856, durante más de un siglo fueron la principal vía promocional y su celebración se convirtió en un evento no solo artístico, sino también social. Se publicaba un Catálogo Oficial, que identificaba títulos y autores. Pero generaban también guías y ediciones paralelas, además de un gran aparato crítico en prensa.Nos ocupamos en concreto de los catálogos humorísticos que parodiaban en versos satíricos el contenido de las Exposiciones. Es una fuente poco conocida y singular, escrita para servir de guía al espectador mientras visitaba la muestra. Sus autores fueron escritores con afianzada trayectoria y también críticos de arte, que aunaban destreza literaria, ingenio y humor. El artículo analiza estas fuentes y recoge amenos ejemplos que ofrecen una alternativa a la crítica de arte en el último tercio del XIX. Palabras clave: Exposiciones Nacionales; catálogo; crítica de arte; humor; arte español.
In Vitro ADME, Preclinical Pharmacokinetics and Prediction of Human Pharmacokinetics of RBx14255, a Novel Ketolide with Pharmacodynamics Against Multidrug-Resistant Bacterial Pathogens
Authors: VETHAKKANI SAMUEL RAJ , Chaira Trdib , Barman Tarani 
Published: June 2020

Purpose: The preclinical pharmacokinetic and pharmacodynamic properties of a potent fluoroketolide RBx14255 against Streptococcus pneumoniae and Haemophilus influenzae was compared with telithromycin and human clinical dose was predicted for preclinical development. Methods: The in vitro pharmacokinetic characterization was performed for solubility, Caco-2 permeability, microsomal stability, CYP inhibition and plasma protein binding. In vivo pharmacokinetic studies were performed in Swiss albino mice, Sprague Dawley rats and Beagle dogs. The pharmacodynamic studies were carried out in mouse against S. pneumoniae in systemic infection and against S. pneumoniae and H. influenzae in rat lung infection models. Results: RBx14255 showed superior potency and efficacy in mouse and rat infection models. RBx14255 showed pH dependent solubility (0.41 mg/mL at pH 6.8 and >1 mg/mL at pH 1.2), moderate Caco-2 permeability (A to B: 12 nm/s) with high efflux ratio. It showed high plasma protein binding (>97%) in mouse and low binding (45-70%) in rat, dog and human. The compound is mainly metabolized through CYP3A4. Pharmacokinetic parameters and absolute bioavailability of both, RBx14255 and telithromycin are similar in mouse. Both the ketolides showed low plasma clearance (18% of the normal hepatic blood flow rate) in mouse, moderate to high clearance in rat and dog. Mean oral bioavailability was high in mouse (≥85%), moderate in rat (RBx14255: 15% and telithromycin: 51%) and high to moderate in dog (RBx14255: 98% and telithromycin: 56%). The predicted efficacious dose for a 70 kg man ranges from 124 mg BID to 226 mg BID. Conclusion: RBx14255 displayed significantly better pharmacodynamics which correlates with the pharmacokinetic properties against S. pneumoniae and H. influenzae as compared to telithromycin. The predicted human efficacious doses are in the range of 124-226 mg, making it amenable to oral dosage form drug in human. This could be a promising clinical candidate for future studies.
Development, Reliability, and Validity of the Perceptions of Brain Injury Survey
Authors: Oyesanya Tolu O. , Turkstra Lyn S. , Brown Roger L. 
Published: June 2020

Background and PurposeThe purpose of this study was to assess psychometric properties of the Perceptions of Brain Injury Survey (PBIS), an instrument designed to assess nurses' perceptions and preparation to care for patients with traumatic brain injury (TBI).MethodsWe adapted two instruments to create the PBIS, and 724 nurses completed the PBIS at three hospitals.ResultsFinal instrument has 66 items and is composed of four subscales, which can be used independently. Results showed Cronbach's alpha for the overall scale was excellent (.93) and alphas for each composite subscale were acceptable to excellent (.73–.93). Findings also suggest good discriminant validity and evidence of external validity.ConclusionsThe PBIS is a reliable and valid measure for assessing nurses' perceptions of caring for patients with TBI in practice or research.
Pemfigus vulgariste çivi belirtisi: Bir olgu sunumu
Authors: ACAR Ayda , KUŞCU AKDENİZ Funda , AKALIN Taner , KARAARSLAN Işıl 
Published: June 2020

Çivi belirtisi, bir lezyondan kaldırılan krut ve skuamın alt yüzeyinde boynuzsu ve dikensi çıkıntıların varlığı olarak tanımlanmaktadır. İlk defa ünlü Türk dermatolog Prof. Dr. Hulusi Behçet tarafından kutanöz layşmanyaziste tanımlanmıştır. Literatürde kutanöz layşmanyazis dışında diskoid lupus eritematozus, pemfigus foliaseus, liken planus, seboreik dermatit, radyoterapi sonrası skalpte gelişen skuamlar ve kutanöz B hücreli lenfoma olgularında da bildirilmiştir.
Burada 68 yaşında erkek hastanın gövde yerleşimli bir pemfigus vulgaris lezyonunda görülen çivi belirtisi, pemfigus vulgariste daha önce çivi belirtisinin tanımlanmamış olması ve ülkemiz dermatologlarının çok iyi bildiği çivi belirtisinin belirgin krut ve skuam ile seyreden pemfigus vulgaris lezyonlarında da görülebileceğinin hatırlatılması amacıyla sunulmaktadır.
Evaluation of wounds due to animals at an emergency department
Authors: KODİK Meltem Songür , GÖKÇEK Kemal , UZ İlhan , KIYAN Güçlü Selahattin 
Published: June 2020

Aim: Due to the risk of rabies contamination and infection, wounds by animals are a significant public health concern. Rabies are still encountered in Turkey. The knowledge of the epidemiology and surveillance of animal bites and rabies prophylaxis is critical in combating this disease. This study aimed to determine the frequency and characteristics of wounds due to animals and rabies prophylaxis at the emergency department of Ege University Faculty of Medicine.
Materials and Methods: In this descriptive and retrospective study, the medical records of patients admitted to the Emergency Department of Ege University Faculty of Medicine between 01.03.2016 and 01.12.2018 with wounds due to animals were reviewed. Of the 427 cases reviewed, four cases (0.9%) due to rats and two patients (0.5%) wounded by bats were not included in the analysis.‎
Results: Of the 421 applicants, 266 were males (63.2%), and 155 were females (36.8%). Forty-five patients (10.6%) were aged ≤10 (10.6%). Adults aged 18-59 years constituted 78.8% (n=332) of the applications. Most commonly, the wounds were in the lower extremities (220, 53.3%). The attacks were made commonly by dogs (n=312, 74.1%). Immunoglobulins were administered to patients who had injuries extending to the subcutaneous tissues (n=23, 5.5%). The majority of the patients were wounded by stray animals (288, 68.4%). All these patients received the rabies vaccine. On the other hand, the majority of patients wounded by owned animals (n=69, 16.4%) got a rabies vaccine as well (n=59, 85.5%).
Conclusion: Our findings indicate that the most significant risks were due to stray animals. It can be concluded that controls and vaccination of owned animals are insufficient, requiring immunization after the injuries. Additionally, to reduce animal bites and prevent rabies, public education about animal bites will be useful as well.
Mujeres, Dones, Mulleres, Emakumeak. Estudios sobre la historia de las mujeres y del género
Authors: Lemus Encarnación 
Published: June 2020

Teresa Ortega López, Ana Aguado Higón, Elena Hernández Sandoica, E., Mujeres, Dones, Mulleres, Emakumeak: Estudios sobre la historia de las mujeres y del género, Madrid, Cátedra, 2019, 421 págs, ISBN 978-84-376-3977-2
Personal Guarante Terhadap Perjanjian Kredit Dengan Jaminan Hak Tanggungan
Authors: Sukmawati, SH* Murlyta Nevi 
Published: June 2020

Didalam pengaturan Hukum Keperdataan Personal guarantee termasuk kedalam kategori penanggungan utang yang dalam sistem hukum nasional kita diatur dalam Pasal 1820-1850 Burgerlijk Wetboek (Selanjutnya disebut BW). Dalam Pasal 1820 BW disebutkan bahwa yang dimaksud dengan penanggungan adalah suatu perjanjian, dimana pihak ketiga, demi kepentingan kreditor, mengikatkan dirinya untuk memenuhi perikatan debitur, bila debitor itu tidak memenuhi perikatannya. Debitor dalam mengajukan utang tidak jarang untuk dimintai jaminan sebagai bentuk perlindungan terhadap terhadap hak kreditor. Tetapi dalam hal ini biasanya yang dijadikan objek jaminan bukan merupakan benda yang dimiliki oleh debitor melainkan pihak ketiga. Dalam lembaga jaminan hak tanggungan sering ditemukan bahwa pihak yang menjaminkan tanahnya sebagai objek hak tanggungan bukanlah si debitor, melainkan pihak ketiga diluar perjanjian kredit yang secara sukarela mengikatkan dirinya. Dalam hal ini penulis akan menyajikan penelitian secara normatif tentang Personal Guarantee dalam perjanjian kredit dengan jaminan Hak Tanggungan.
Secondary Syphilis in Human Immunodeficiency Virus (HIV)-Infected Men Who Have Sex with Men (MSM): A Case Report
Authors: Fernandes Ade , Ervianti Evy 
Published: June 2020

Background: Recently, the incidence of syphilis among men who have sex with men (MSM) has increased rapidly, especially among Human Immunodeficiency Virus (HIV)-infected MSM. Coinfection with these two organisms alter the symptoms and signs, progression of the disease, and the risk of progressing to the tertiary stage. Purpose: To report a case of secondary syphilis in HIV-infected MSM. Case: A 24-year-old male complaint of multiple redness macule for 1-month duration on his chest, back, groin, palm, and soles. The rash was neither painful nor pruritic. He also complains of hair loss resulting "moth eaten" alopecia. One month before, he had a painless ulcer on his genital, which resolved without treatment. His HIV infection was diagnosed two years earlier. He had been sexually active with multiple homosexual partners without using a condom since 2010. The Venereal Disease Research Laboratory test (VDRL) titer was 1/32, and Treponema pallidum haemagglutination assay (TPHA) was 1/20480. Initial treatment was a single dose of 2.4 million units of benzathine penicillin. Serologic examination was reevaluated on month 1, 3, 6, and 9 after therapy and declined in the third month. Discussion: For HIV-infected persons, the clinical manifestations of syphilis in most of the cases remain the same. However, the lesions are more aggressive, and coexistence of primary and secondary syphilis is more frequent. Serologic tests are accurate and reliable for the diagnosis and for following a patient’s response to treatment. Penicillin is effective but physical and serological follow up is needed. Conclusion: HIV-infected MSM have higher risk of syphilis. Staging is needed to determine the treatment. Serologic examination should be repeated and long enough to monitor the treatment success.
PENGARUH BAHAN PENGENCER SARI KACANG KEDELAI (Glycine max) TERHADAP VIABILITAS DAN NEKROSIS SPERMATOZOA DOMBA SAPUDI
Authors: Immelda Kicky Hanis , Susilowati Suherni , Yudaniayanti Ira Sari 
Published: June 2020

The purpose of study was to find out the effect of different concentrations of soya bean extractin sperm diluter, stored at 5°C toward sperm viability and necrosis. The semen was divided into four groups : P0: 0.1 ml sapudi ram + 1 ml of diluent yolk citrate, P1: sapudi ram 0.1 ml + 1 ml diluent soybeans extract konsentration 5%, P2: 0.1 ml sapudi ram + 1 ml diluent soybeans extract konsentration 10%, P3: 0.1 ml sheep semen + 1 ml diluent soybeans konsentration 15%. The result showed that the dose of soya bean extract diluter konsentration of 15% could increase the viability percentage and could decrease the necrosis percentage of sperm.
Kualitas spermatozoa post-thawing pejantan sapi Friesian Holstein pada umur yang berbeda
Authors: Ristiani Widya Aulia , Yunus Muhammad , Suprayogi Tri Wahyu , Srianto Pudji , Mustofa Imam , Rimayanti Rimayanti 
Published: June 2020

This study aimed to determine the post-thawing spermatozoa quality of Holstein-Friesian (HF) bulls at different ages. The samples were HF frozen semen of 3, 5, and 8-years -old age group produced by the Singosari National Artificial Insemination Center. Nine samples of each group were randomly purposive sampling, thawed in 37ºC water for 15 seconds, and assessed on the percentage of viability, motility, and abnormality of spermatozoa. The obtained data were analyzed using the ANOVA method, followed by Duncan's multiple range test at a 95% confidence level. The result showed that post-thawing spermatozoa viability in 5 and 8-year-old HF bull were 67 ± 6.67%, and 78 ± 7.59, both were higher (p <0.05) compared to 62.78 ± 5.76% in HF bulls 3-yearsold group. Likewise, the motility of those bull aged 5 and 8 years (69.44 ± 6.82 and 65.00 ± 9.68%, respectively) were higher (p <0.05) compared to 55, 56 ± 5.83% in 3-year-old HF bull. Meanwhile, the percentage of post-thawing spermatozoa abnormalities in the three age groups were 4.33 ± 1.96%, 5.89 ± 1.90%, and 5.33 ± 1.41%, not significantly different (p> 0.05) respectively. It concluded that the best quality of post-thawing HF semen based on the percentage of viability, motility, and morphologic abnormality was collected from 5-8 years old bull. Nevertheless, spermatozoa from the three age goups still meet the Indonesia standard quality of frozen semen for artificial insemination.
Sand Screen with Check-Valve Inflow Control Devices
Authors: Dikshit Ashutosh , Kumar Amrendra , Anikanov Evgeny , Petukhov Pavel , Rudic Aleksandar , Woiceshyn Glenn , Gadiyar Bala , Parlar Mehmet , Jurgensen Camilo 
Published: June 2020

Summary
Sand control screens are installed with an internal string (wash pipe) as required which, among other functions, provides a circulation path. In long horizontal wells, running a wash pipe consumes considerable rig time and may limit the ability to reach target depth. In cases in which fluid losses are experienced after screen installation, isolating the open hole with a fluid-loss control valve can be prolonged. This paper describes a wash-pipe-free solution for screen installation using a check-valve inflow control device (CV-ICD).
ICD screens are commonly used to delay/restrict the influx of unwanted fluids such as gas or water. The wash-pipe-free solution integrates a check valve with the ICD to prevent outflow through the screen during circulation and allows inflow through the screen when placed on production. This solution uses a check ball that seals against the ICD during circulation but falls back on a porous retainer plate during production. The check ball and retainer plate can be dissolved by spotting a reactive fluid inside the screen or made to erode over time with production.
Laboratory testing yielded the following results: the ICD with the check ball was shown to seal up to 5,000 psi; the check ball and retainer plate can be dissolved by a reactive fluid, which can be tailored to bottomhole temperature and the required time of dissolution; and the pressure activation test demonstrated that the maximum differential pressure to seat the ball was less than 5 psi.
This CV-ICD solution has been applied worldwide in more than 35 wells, most of which were targeted to avoid running a wash pipe. However, in two wells the technology was successfully used to set openhole packers with a 5,000-psi setting pressure. In this paper, we present the wash-pipe-free ICD screen installation with a dissolvable check valve and the capability of setting a hydraulic packer without a wash pipe or intervention in the open hole. The novel contribution presented herein is the ability to integrate a ball and cage to existing nozzle-based ICDs by using dissolvable material to achieve the preceding results in this application.
A Novel Method for Diagnosis of Sucker-Rod Pumping Systems Based on the Polished-Rod Load Vibration in Vertical Wells
Authors: Yin JiaoJian , Sun Dong , Yang Yousheng 
Published: June 2020

Summary
The pump dynamometer card is a direct reflection of the operating conditions of the downhole pump, which is important for the diagnosis of sucker-rod pumping systems. In this paper, we propose a novel diagnostic method based on the estimation of the parameters from the polished-rod load vibration signal of sucker-rod pumping systems in a vertical well. In this study, we deduce a new analytic solution of the 1D wave equation of the sucker-rod string, which can be used for the predictive and diagnostic analyses. The relationship between the polished-rod load vibration and the pump equivalent impulse load based on the analytic solution is studied, and the diagnostic parameter estimating method is proposed. Therefore, the pump dynamometer card calculated method based on the surface dynamometer card is realized. This study shows that the method is efficient.