bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced Hydrogen Evolution in Neutral Water Catalyzed by a Cobalt Complex with a Softer Polypyridyl Ligand
Authors: Wang Ping , Liang Guangchao , Smith Noah , Hill Kyra , Donnadieu Bruno , Webster Charles Edwin , Zhao Xuan 
Published: April 2020

AbstractTo explore the structure–function relationships of cobalt complexes in the catalytic hydrogen evolution reaction (HER), we studied the substitution of a tertiary amine with a softer pyridine group and the inclusion of a conjugated bpy unit in a Co complex with a new pentadentate ligand, 6‐[6‐(1,1‐di‐pyridin‐2‐yl‐ethyl)‐pyridin‐2‐ylmethyl]‐[2,2′]bipyridinyl (Py3Me‐Bpy). These modifications resulted in significantly improved stability and activity in both electro‐ and photocatalytic HER in neutral water. [Co(Py3Me‐Bpy)(OH2)](PF6)2 catalyzes the electrolytic HER at −1.3 V (vs. SHE) for 20 hours with a turnover number (TON) of 266 300, and photolytic HER for two days with a TON of 15 000 in pH 7 aqueous solutions. The softer ligand scaffold possibly provides increased stability towards the intermediate CoI species. DFT calculations demonstrate that HER occurs through a general electron transfer/proton transfer/electron transfer/proton transfer pathway, with H2 released from the protonation of CoII−H species.
Reductive Deamination with Hydrosilanes Catalyzed by B(C6F5)3
Authors: Fang Huaquan , Oestreich Martin 
Published: April 2020

AbstractThe strong boron Lewis acid tris(pentafluorophenyl)borane B(C6F5)3 is known to catalyze the dehydrogenative coupling of certain amines and hydrosilanes at elevated temperatures. At higher temperature, the dehydrogenation pathway competes with cleavage of the C−N bond and defunctionalization is obtained. This can be turned into a useful methodology for the transition‐metal‐free reductive deamination of a broad range of amines as well as heterocumulenes such as an isocyanate and an isothiocyanate.
Attenuation of Murine Collagen‐Induced Arthritis by Targeting CD6
Authors: Li Yan , Ruth Jeffrey H. , Rasmussen Stephanie M. , Athukorala Kalana S. , Weber Daniel P. , Amin M. Asif , Campbell Phillip L. , Singer Nora G. , Fox David A. , Lin Feng 
Published: April 2020

ObjectiveCD6 is an important regulator of T cell function that interacts with the ligands CD166 and CD318. To further clarify the significance of CD6 in rheumatoid arthritis (RA), we examined the effects of targeting CD6 in the mouse model of collagen‐induced arthritis (CIA), using CD6‐knockout (CD6‐KO) mice and CD6‐humanized mice that express human CD6 in lieu of mouse CD6 on their T cells.MethodsWe immunized wild‐type (WT) and CD6 gene–KO mice with a collagen emulsion to induce CIA. For treatment studies using CD6‐humanized mice, mice were immunized similarly and a mouse anti‐human CD6 IgG (UMCD6) or control IgG was injected on days 7, 14, and 21. Joint tissues were evaluated for tissue damage, leukocyte infiltration, and local inflammatory cytokine production. Collagen‐specific Th1, Th9, and Th17 responses and serum levels of collagen‐specific IgG subclasses were also evaluated in WT and CD6‐KO mice with CIA.ResultsThe absence of CD6 reduced 1) collagen‐specific Th9 and Th17, but not Th1 responses, 2) the levels of many proinflammatory joint cytokines, and 3) serum levels of collagen‐reactive total IgG and IgG1, but not IgG2a and IgG3. Joint homogenate hemoglobin content was significantly reduced in CD6‐KO mice with CIA compared to WT mice with CIA (P < 0.05) (reduced angiogenesis). Moreover, treating CD6‐humanized mice with mouse anti‐human CD6 monoclonal antibody was similarly effective in reducing joint inflammation in CIA.ConclusionTaken together, these data suggest that interaction of CD6 with its ligands is important for the perpetuation of CIA and other inflammatory arthritides that are T cell driven.
3D Hollow Flower‐like CoWO4 Derived from ZIF‐67 Grown on Ni‐foam for High‐Performance Asymmetrical Supercapacitors
Authors: Chu Dawei , Guo Dongxuan , Xiao Boxin , Tan Lichao , Ma Huiyuan , Pang Haijun , Wang Xinming , Jiang Yanxia 
Published: April 2020

AbstractA three‐dimensional (3D) hollow CoWO4 composite grown on Ni‐foam (3D−H CoWO4/NF) based on a flower‐like metal‐organic framework (MOF) is designed by utilizing a facile dipping and hydrothermal approach. The 3D−H CoWO4/NF not only possesses large specific areas and rich active sites, but also accommodates volume expansion/contraction during charge/discharge processes. In addition, the unique structure facilitates fast electron/ion transport of 3D−H CoWO4/NF. Meanwhile, a series of characterization measurements demonstrate the appropriate morphology and excellent electrochemical performance of the material. The 3D−H CoWO4/NF possesses a high specific capacitance of 1395 F g−1, an excellent cycle stability with 89% retention after 3000 cycles and superior rate property. Furthermore, the 3D−H CoWO4/NF can be used as a cathode to configurate an asymmetric supercapacitor (ASC), and 3D−H CoWO4/NF//AC shows a good energy density (29.0 W h kg−1). This work provides a facile method for the preparation of 3D‐hollow electrode materials with high electrochemical capability for advanced energy storage devices.
The metabolites and biotransformation pathways in vivo after oral administration of ocotillol, RT5, and PF11
Authors: Liu Jihua , Gan Huizhu , Li Ting , Wang Jia , Du Guangguang , An Yang , Yan Xiaojing , Geng Cong 
Published: April 2020

AbstractOcotillol, pseudo‐ginsenoside RT5 (RT5), and pseudo‐ginsenoside F11 (PF11) are ocotillol‐type saponins that have the same aglycone structure but with different numbers of glucose at the C‐6 position. In this study, the metabolites of ocotillol, RT5, and PF11 in rat plasma, stomach, intestine, urine, and feces after oral administration were investigated by ultra‐performance liquid chromatography coupled with time‐of‐flight mass spectrometry. The results showed that RT5 was easily biotransformed into metabolites in vivo, whereas PF11 and RT5 were difficult to be biotransformed. Hydrogenation, dehydrogenation, dehydration, deglycosylation, deoxygenation, hydration, phosphorylation, deoxidation, glucuronidation, and reactions combining amino acid were speculated to be involved in the biotransformation of ocotillol, RT5, and PF11. Based on the structural analysis of metabolites, it was deduced that hydrogenation, dehydration, deoxidation, and reactions combining amino acid occurred on the aglycone structure, whereas deglycosylation, hydration, and phosphorylation occurred on the glycosyl chain. Further, metabolites in plasma, urine, feces, and tissues were different: First, glucuronidation products were found in urine, stomach, intestine, and feces, but not in plasma. Second, the ocotillol prototype was not identified in urine samples. Third, the RT5 prototype was found in stomach, intestine, feces, and urine, but not in plasma.
An improved LC–MS/MS method for determination of docetaxel and its application to population pharmacokinetic study in Chinese cancer patients
Authors: Yang Jia , Li Xingang , Li Wenjun , Xi Xin , Du Qian , Pan Feng , Liu Songqing 
Published: April 2020

AbstractBecause of its unpredictable side effects and efficacy, the anticancer drug docetaxel (DTX) requires improved characterisation of its pharmacokinetic profiles through population pharmacokinetic studies. A sensitive and rugged LC–MS/MS method for the detection of DTX in human plasma was developed and optimised using paclitaxel as an internal standard (IS). The plasma samples underwent rapid extraction using hybrid solid‐phase extraction‐protein precipitation. The analyte and IS were separated with an isocratic system on a Zorbax Eclipse Plus C18 column using water containing 0.05% acetic acid along with 20 μM of sodium acetate and methanol (30/70, v/v) as the mobile phase. Quantification was performed using a triple quadrupole mass spectrometer through multiple reaction monitoring in positive mode, using the m/z 830.3 → 548.8 and m/z 876.3 → 307.7 transitions for DTX and paclitaxel, respectively. The range of the calibration curve was 1–500 ng/mL for DTX, and the linear correlation coefficient was >0.99. The accuracies ranged from −4.6 to 4.2%, and the precision was no higher than 7.0% for the analytes. No significant matrix effect was observed. Both DTX and the IS showed considerable recovery. This method was finally applied to the establishment of a population pharmacokinetic model to optimise the clinical use of DTX.
Goal activation for sustainable consumer choices: A comparative study of Denmark and Brazil
Authors: Thøgersen John , Alfinito Solange 
Published: April 2020

AbstractTo study the context dependence of the impact of goal activation on sustainable consumer choices in an online survey, 1,031 participants in Denmark and 1,028 in Brazil were randomly allocated to three different goal‐activation manipulations, which were set up to activate a normative goal, a hedonic goal, and a gain goal, respectively. Goal‐activation impacts were measured with a choice experiment consisting of six repeated choices of tomatoes. The importance for consumer choices of each of the varied product attributes for consumer choices can be linked to characteristics that differ between countries. Therefore, it was predicted that the importance of attributes differs between Denmark and Brazil. This was confirmed for one of the three attributes (appearance), but not for the other two (organic and price). Still, as predicted, the goal‐activation manipulation influenced the impact of varied product attributes (two out of three) on choices. The activation of a normative goal made participants in both countries more likely to choose organic tomatoes and less focused on the appearance of the tomatoes. However, the goal‐activation manipulation did not influence the importance of the price. The findings suggest that the situational activation of a normative goal can be an effective means to promote sustainable consumer choices in very different national contexts.
Biosynthesis of NiFe2O4@Ag Nanocomposite and Assessment of Its Effect on Expression of norA Gene in Staphylococcus aureus
Authors: Pourmehdi Nozhat , Moradi‐Shoeili Zeinab , Sadat Naeemi Akram , Salehzadeh Ali 
Published: April 2020

AbstractActivity of norA efflux pump has been known as a resistance mechanism to antibiotics like ciprofloxacin in Staphylococcus aureus. This study was carried out to assess the effect of biosynthesized NiFe2O4@Ag nanocomposite on expression of norA gene in Staphylococcus aureus.In this experimental study, 30 clinical samples were collected from patients hospitalized at different hospitals in Guilan Province, Iran. Then, clinical isolates of S. aureus were identified by standard microbiological tests. Antimicrobial susceptibility tests of clinical and standard strains of S. aureus were done by disk diffusion method according to CLSI guideline. Fourier transform infrared spectroscopy (FT‐IR) was used to analyze the various functional groups present in the biosynthesized NiFe2O4@Ag nanocomposite. This analysis confirmed the formation of alga proteins coated on magnetite nanocomposite. X‐ray diffraction (XRD) verified the crystalline structure of NiFe2O4@Ag and the deposition of silver on the surface of NiFe2O4. Energy dispersive X‐ray mapping (EDX‐map) analysis confirmed the existence of Ag, Ni, Fe and O in the final product. Scanning electron microscopy (SEM) confirmed that the nanocomposites were spherical in shape and Transmission electron microscopy (TEM) results revealed that the NiFe2O4@Ag had the particle size about 100 nm. Antibacterial activity of NiFe2O4@Ag alone and combined with ciprofloxacin was evaluated using the disk assay method, and minimum inhibitory concentration (MIC) by broth dilution method. Afterwards, the expression of norA efflux pump gene with and without of NiFe2O4@Ag nanocomposite and ciprofloxacin was evaluated by Real‐Time PCR. Real‐Time PCR results demonstrated that the expression of norA gene in the strains exposed to both NiFe2O4@Ag nanocomposite (1/4 MIC) and ciprofloxacin (1/8 MIC) significantly reduced in comparison to untreated strains. This study reveals that, when NiFe2O4@Ag nanocomposite is combined with ciprofloxacin, the inhibitory effect of ciprofloxacin increases against growth of S. aureus. Therefore, NiFe2O4@Ag nanocomposite can be considered as an effective factor to decrease the growth of S. aureus along with ciprofloxacin.
Divergent and Multi‐Stage Photoisomerization of Four‐Coordinated Boron Compounds with a Naphthyl‐Pyridyl/Thiazolyl Backbone
Authors: He Zhechang , Liu Lijie , Zhao Zhenhui , Mellerup Soren. K. , Ge Yuxin , Wang Xiang , Wang Nan , Wang Suning 
Published: April 2020

AbstractExamination of the photoreactivity of a new class of N,C‐chelate organoboron compounds, including a series of unsymmetrically substituted boron molecules, B(naph‐pyridyl)(Ar1)(Ar2) and B(naph‐thiazolyl)(Ar1)(Ar2), led to the discovery of new and divergent photothermal isomerization phenomena. These include the clean and regioselective photoisomerization by unsymmetrical boron, forming borepin isomers, some of which further isomerize to the corresponding boratanorcaradiene diastereomer pairs as a result of the generation of two chiral centers. Significantly, the boratanorcaradienes involving a 3‐thienyl substituent on boron were found to thermally convert to BN‐fluoranthene annulated borapentalene via an unprecedented reversible boratacyclopropane–boratacyclopentene rearrangement. Changing the pyridyl donor to a thiazolyl donor on the boron was found to provide the B(naph‐thiazolyl)(Mes)2 compounds with a distinct new photoisomerization pathway—instead of borepin, forming new blue fluorescent polycyclic azaborinine species. This work illustrates the richness and complexity of boron photochemistry.
Pentathiepins: A Novel Class of Glutathione Peroxidase 1 Inhibitors that Induce Oxidative Stress, Loss of Mitochondrial Membrane Potential and Apoptosis in Human Cancer Cells
Authors: Behnisch‐Cornwell Steven , Bandaru Siva Sankar Murthy , Napierkowski Martin , Wolff Lisa , Zubair Muhammad , Urbainsky Claudia , Lillig Christopher , Schulzke Carola , Bednarski Patrick J. 
Published: April 2020

AbstractA novel class of glutathione peroxidase 1 (GPx1) inhibitors, namely tri‐ and tetracyclic pentathiepins, has been identified that is approximately 15 times more potent than the most active known GPx1 inhibitor, mercaptosuccinic acid. Enzyme kinetic studies with bovine erythrocyte GPx1 indicate that pentathiepins reversibly inhibit oxidation of the substrate glutathione (GSH). Moreover, no inhibition of superoxide dismutase, catalase, thioredoxin reductase or glutathione reductase was observed at concentrations that effectively inhibit GPx1. As well as potent enzyme inhibitory activity, the pentathiepins show strong anticancer activity in various human cancer cell lines, with IC50 values in a low‐micromolar range. A representative tetracyclic pentathiepin causes the formation of reactive oxygen species in these cells, the fragmentation of nuclear DNA and induces apoptosis via the intrinsic pathway. Moreover, this pentathiepin leads to a rapid and strong loss of mitochondrial membrane potential in treated cancer cells. On the other hand, evidence for the induction of ferroptosis as a form of cell death was negative. These new findings show that pentathiepins possess interesting biological activities beyond those originally ascribed to these compounds.
Big data and sentiment analysis: A comprehensive and systematic literature review
Authors: Hajiali Mahdi 
Published: April 2020

SummarySentiment analysis can extract information from many text sources such as reviews, news, and blogs; then it classifies them based on their polarity. Moreover, big data is produced via mobile networks and social media. Applications of sentiment analysis on big data are used as a way of classifying the opinions into diverse sentiment. Accordingly, performing sentiment analysis on big data can be helpful for a business to take useful commercial insights from text‐oriented content. However, there are very few comprehensive investigations and profound argument in this context. The goal of this paper is to provide a comprehensive and systematic investigation of the state‐of‐the‐art techniques and highlight the directions for future research. In this paper, we used systematic literature review method and in the first step, we obtained 15 351 articles; then, based on different filters, 48 related articles were attained. We have selected 23 articles based on the year of publication, the relevance of the journal, the completeness of the text, the nonrepeatability of the title, and the page number. Also, we have categorized big data and sentiment analysis into two classifications: centralized and distributed platforms. Furthermore, the disadvantages and advantages of the investigated techniques are studied and their key issues are emphasized. Consequently, this study shows that a better analysis of textual big data in terms of sentiment increases efficiency, flexibility, and intelligence. By providing comparative information and analyzing the current developments in this area, this paper will directly support academics and practicing professionals for better handling of big data in the field of sentiment analysis. This study sheds some new light on using sentiment analysis and big data for public opinion estimation and prediction.
An Italian validation of the Comparative Psychotherapy Process Scale: Reliability and validity
Authors: Gentile Daniela , Colli Antonello , Lingiardi Vittorio 
Published: April 2020

AbstractThe Comparative Psychotherapy Process Scale (CPPS) is an instrument designed to measure therapist interventions in a psychotherapy session. The scale includes 20 items divided into two subscales: the PI (psychodynamic‐interpersonal) scale, which describes psychodynamic‐interpersonal techniques; and the CB (cognitive‐behavioural) scale, which includes cognitive‐behavioural interventions. The aim of the study was to examine the psychometric properties of the CPPS, comparing the PI and CB subscales with the psychodynamic, cognitive and STTP prototypes, as described by the Psychotherapy Process Q‐set(PQS). The sample comprised 94 sessions (N = 94) of psychodynamic and cognitive‐behavioural orientation. Two groups of independent raters with excellent interrater reliability (ICC = .78) evaluated the sessions. The results suggest that the CPPS is a valid and reliable instrument that provides a clinically sensitive and psychometrically robust evaluation of a therapist's techniques. The clinical and research implications of the results are discussed.
Ternary Cathode Blend Electrodes for Environmentally Friendly Lithium‐Ion Batteries
Authors: Jobst Nicola Michael , Hoffmann Alice , Klein Andreas , Zink Stefan , Wohlfahrt‐Mehrens Margret 
Published: April 2020

AbstractThe combination of two active materials into one positive electrode of a lithium‐ion battery is an uncomplicated and cost‐effective way to combine the advantages of different active materials while reducing the disadvantages of each material. In this work, the concept of binary blends is extended to ternary compositions. The combination of three different active materials provides high versatility in designing the properties of an electrode. Therefore, the unique properties of a layered oxide, phospho‐olivine, and spinel type material are mixed to design a high‐energy cathode with improved environmental friendliness. Four different compositions of blend electrodes are investigated, each with individual benefits. Synergistic effects improved the rate capability, power density, thermal and chemical stability simultaneously. The blend electrode consisting of 75 % NMC, 12.5 % LMFP and LMO provides similar energy and power density as a pure NMC electrode while economizing 25 % cobalt and nickel.
In Vivo Flow Cytometric Evaluation of Circulating Metastatic Pancreatic Tumor Cells after High‐Intensity Focused Ultrasound Therapy
Authors: Yu Qian , Yao Yijing , Zhu Xi , Gao Yihui , Chen Yini , Wang Rui , Xu Pingping , Wei Xunbin , Jiang Lixin 
Published: April 2020

AbstractWe examined our hypothesis that high‐intensity focused ultrasound (HIFU) treatment of pancreatic ductal adenocarcinoma (PDAC) in nude mice models may lead to an increased occurrence of hematogenous metastasis. The human PDAC cell line BxPC‐3 transfected with mCherry was implanted into nude mice to establish orthotopic and subcutaneous xenograft (OX and SX) tumor models. Mice were exposed to HIFU when tumor sizes reached approximately 200–300 mm3. The OX and SX tumor models were monitored continuously for tumor growth characteristics and hematogenous metastasis using in vivo flow cytometric (IVFC) detection of circulating tumor cells (CTCs) from the pancreas. We chose an appropriate mouse model to further examine whether or not HIFU increases the potential risk of hematogenous metastasis, using IVFC detection. Our results showed that the CTC number was greater in the OX model than in the SX model. The CTC number in the OX model increased gradually over time, whereas the CTC number in the SX model remained low. Therefore, the OX model was better for studying tumor metastasis by IVFC detection. We found significantly decreased CTC numbers and tumor volume after HIFU ablation. Our results showed the applicability of the PDAC OX tumor model for studying the occurrence of tumor metastasis due to the generation of CTCs. HIFU ablation substantially restricted PDAC hematogenous metastasis and provided effective tumor control locally. © 2020 The Authors. Cytometry Part A published by Wiley Periodicals Inc., on behalf of International Society for Advancement of Cytometry.
A Caretaker Acute Stress Paradigm: Effects on behavior and physiology of caretaker and infant
Authors: Tronick Ed , Mueller Isabelle , DiCorcia Jennifer , Hunter Richard , Snidman Nancy 
Published: April 2020

AbstractWhile experimental stress paradigms of infants (arm restraint; the Still‐Face) are powerful tools for infant research, no study has experimentally stressed mothers to observe its independent effects on infant stress regulation. Extant caretaker/maternal stress studies essentially are correlational and confounded by other conditions (e.g., depression). Here, we present a standard procedure, the Caregiver Acute Stress Paradigm (CASP), for stressing mothers during en face interactions with their infants. We hypothesized that infants of the stressed mothers would be more distressed than infants of non‐stressed mothers. A total of 106 four‐month‐old infants and their mothers were randomly assigned to the experimental stress or non‐stress manipulation. Confirming our hypothesis, infants of the stressed mothers were significantly more likely to become distressed and require terminating the procedure. While objective ratings of maternal behavior showed no difference between groups, mother in the stress condition self‐rated the episode following the caretaker stress significantly lower than mothers in the non‐stress group. The self‐ratings in the maternal stress‐group were reflected in infant cortisol. The findings indicate that CASP is an effective experimental paradigm for exploring the independent effects of an acute stress on caretakers, including effects of conditions, such as poverty or mental illness.