bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dampak perceraian orang tua terhadap perkembangan psikososial dan prestasi belajar
Authors: Mone Harry Ferdinand 
Published: February 2020

Tujuan yang dicapai pada penelitan ini mendeskripsikan: 1.) Dampak perceraian orang tua terhadap perkembangan psikososial anak; 2.) Dampak perceraian orang tua terhadap prestasi belajar anak; 3.) Langkah-langkah pemulihan perkembangan psikososial anak akibat perceraian orang tua; dan 4) langkah-langkah pemulihan prestasi belajar anak akibat perceraian orang tua. Penelitian ini berlokasi di kecamatan Oebobo, kota Kupang. Penelitian ini menggunakan pendekatan fenomenologi dengan menggunakan metode kualitatif deskriptif. Subjek dalam penelitian ini adalah pasangan yang bercerai dengan orang, keluarga, tetangga, anak, dan guru wali kelas, yang berjumlah 35 orang. Hasil penelitian yang diperoleh: 1.) Perceraian (cerai hidup) membawa dampak yang negatif terhadap perkembangan psikososial dan prestasi belajar anak; 2.) Emosi atau perasaan anak sangat mempengaruhi aktivitas belajar di sekolah maupun di rumah, baik perasaan sedih, gembira, aman, marah, cemas, takut dan lain sebagainya; 3.) Adanya komunikasi antara orang tua dan anak setelah bercerai memperkecil pengaruh negatif dari perceraian. Kasih sayang dari keluarga kedua belah pihak dan bantuan guru dalam mengasuh anak korban perceraian di rumah dan sekolah, membuat anak kuat dan tegar menghadapi masalah keluarganya; dan 4.) Langkah pemulihan prestasi belajar yakni bersifat mendidik, misalnya memberikan pujian, hadiah, dan lain sebagainya yang mengandung nilai edukatif. AbstractThe objectives achieved on this research describe: 1.) The impact of divorce of parents to the psychosocial development of children; 2.) The impact of divorce of parents on children's learning achievement; 3.) The measures of recovery of child psychosocial development due to divorce Parents; and 4.) The steps of recovering children's learning achievement due to parents ' divorce. Research data and located in Oebobo sub-district Kupang. This study uses phenomenological approaches using qualitative descriptive methods. The subject in this study was a couple who divorced people, a family, a neighbor, the child, and a homeroom teacher, whom It amounted to 35 people. Results of research obtained; Divorce (divorced) carries a negative impact on psychosocial development and child learning achievement. Emotions or feelings of children significantly affect the learning activities at school or home, whether feeling sad, joyful, safe, angry, anxious, afraid, and so on. The communication between parents and children after divorce minimized the negative influence of divorce. The affection of the family both sides and the help of teachers in caring for the child's divorce victims at home and school, making the child active and rigid facing his family problem. The steps of learning achievement are educational, such as giving praise, gifts, and others that contain an educative value.
THE EFFECTS OF PHALERIA MACROCARPA EXTRACT ON MITOTIC INDEX AND TUMOR MASS PROGRESSION OF EPIDERMOID CARCINOMA IN SWISS MICE: IN VIVO EXPERIMENTAL STUDY IN SWISS MICE TREATED WITH NEOADJUVANT PACLITAXEL AND CISPLATIN
Authors: VITO MAHENDRA EKASAPUTRA  , MUHAMAD THOHAR ARIFIN  , DJOKO HANDOJO  
Published: February 2020

Objectives: Polyphenols in Phaleria macrocarpa (mahkota dewa) can inhibit mitogen-activated protein kinase activity in receptor tyrosine kinases pathway. This can be recognized from the decrease of mitotic index as a response to malignant cells and the reduction of tumor development. This study aimed to determine whether P. macrocarpa may decrease the mitotic index and tumor diameter in epidermoid carcinoma.
Methods: The experiment was conducted on 18 epidermoid carcinoma induced Swiss mice divided into four groups: Control, Phaleria administered (0.0715 mg [0.36 ml]/day), chemotherapy administered (paclitaxel 175 mg/m2 and cisplatin 50 mg/m2), and combination group. Tumor size diameter was measured before and after treatment in 9 weeks. Mitotic index was measured at the end of the treatment.
Results: There were significant differences in the mitotic index and changes in tumor diameter among groups compared with the control group. The most significant growth inhibition and decrease in mitotic index were in group four. There was a significant positive correlation between tumor mitotic index and changes in tumor diameter (r=0.813).
Conclusion: P. macrocarpa is able to decrease tumor cells’ mitotic index and inhibit epidermoid carcinoma’s tumor mass progression in Swiss mice.
STUDY OF ANTIBACTERIAL AND ANTIFUNGAL EFFECT OF THE ESSENTIAL OILS OF CHENOPODIUM AMBROSIOIDES L. AND ROSMARINUS OFFICINALIS L.
Authors: MAMMAD ZINEB  , TORMAL DJASSINRA  , KRIBII ABDERAHIM  , OUNINE KHADIJA  
Published: February 2020

Objective: This work looks at the valuation of two medicinal plants growing wild in the region of Gharb (Chenopodium ambrosioides L. and Rosmarinus officinalis L.) through the study of their antibacterial and antifungal effects vis-à-vis Xanthomonas fragariae, Pseudomonas aeruginosa, Staphylococcus aureus, and two fungal strains; Fusarium solani and Botrytis cinerea.
Methods: The extraction of essential oils from each plant was carried out by hydrodistillation in a Clevenger-type apparatus. The antibacterial and antifungal tests of essential oils are carried out according to the method of diffusion using sterile discs (or aromatograms). Results are expressed in inhibition areas.
Results: Antibacterial activity of essential oil of R. officinalis L. is best compared to that of C. ambrosioides L. with an area of inhibition that is shared by 1661.06 and 1384.74, respectively, for bacteria X. fragariae and P. aeruginosa, while this area is between 2122.64 and 2826 mm2 for F. solani and B. cinerea. Moreover, the essential oils of these two plants by the method of disk diffusion feature a very significant inhibitory effect on X. fragariae and P. aeruginosa, whereas they have no effect on S. aureus.
Conclusion: The essential oils of C. ambrosioides L. and R. officinalis L. could be used as preservatives in food, to protect them from microbial or fungal spoilage.
SPECTROFLUORIMETRIC DETERMINATION OF EOSIN CHEMILUMINESCENCE SYSTEM FOR THE ANALYSIS OF DABIGATRAN IN PHARMACEUTICAL FORMULATIONS
Authors: DHANAPAL Y  , SRUDHIVINOD V  , MOHAMAD WASEEM A  
Published: February 2020

Objectives: The objectives of this study were to develop a rapid, simple, and economical spectrofluorometric method for quantification of dabigatran from marketed formulation and its principle involved based on the protonated process of a binary mixture complex formation with eosin Y.
Methods: A simple and precise spectrofluorometric technique was applied for the method development. It depends on measuring the quenching effect of the drug on the native fluorescence of eosin at excitation under the optimum reaction conditions.
Results: The reaction linear calibration graph constructed between the fluorescence quenching valves flouresence intensity (ΔF) and the concentration ranges of 5–50 μg/ml. Spectrofluorometric analytical performance was validated by accuracy, precision, and specificity, and the results were satisfactory.
Conclusion: This method was to develop a fast, simple, and economically applied successfully for the assay, and qualification of dabigatran tablet contains drug, also with different coformulated pharmaceutical formulations.
STUDY OF TUMOR MICROENVIRONMENT AND HOST RESPONSE IN COLORECTAL CANCER: IMMUNOHISTOCHEMICAL AND CLINICOPATHOLOGICAL APPROACH
Authors: NORIA OTHMAN RAFFALLA  , SUZAN MOHAMED FAROUK HELAL  , AMANY ABD EL-BARY ABD EL-LATIF  , RASHA OMAR ELSAKA  
Published: February 2020

Objective: This study aimed to evaluate the immunohistochemical expression of forkhead boxP3 (Foxp3), CD8, CD68, and CD21 in stroma between tumor cells of colorectal cancer (CRC) patients and examines the relationship between these variables and clinicopathological parameter and patients’ prognosis.
Methods: In this work, 50 cases of colorectal carcinomas were included and immunohistochemical evaluation of Foxp3, CD8, CD68, and CD21 in tumor tissue samples.
Results: Tumor-infiltrating lymphocytes (TILs) including cytotoxic T cells and regulatory T cells as well as tumor-associated macrophages and follicular dendritic cells (FDCs) were studied in the stroma of the tumor using immunostaining technique for CD8, Foxp3, CD68, and CD21, respectively. Cases were followed up. CD8-positive cytotoxic T cells, Foxp3-positive regulatory T cells, and CD21 positive-FDCs were significantly more pronounced in early tumors and those with longer overall survival. On the other hand, CD68 positive macrophages were more encountered in late stage and metastatic tumors as well as tumors with shorter overall survival, but these results not reached the level of significance.
Conclusion: We concluded that (TILs) and FDCs are conferring better prognosis in CRCs, they may act synergistically in stimulating a protective immune response in the tumor microenvironment that hinders tumor progression, while the role of tumor-associated macrophages in CRCs is still controversial and needs further studies.
OBESITY AS A COMMON COMORBIDITY IN PATIENTS WITH DIABETES: OCCURRENCE BASED ON EATING HABITS AND OTHER DETERMINANTS IN WEST JAVA, INDONESIA
Authors: SUHARTATIK MELIZA , DEWI SARTIKA RATU AYU 
Published: February 2020

Objective: The prevalence of obesity in individuals with diabetes mellitus (DM) is fairly high. It has been shown that obesity worsens insulin resistance and can elevate the risk for complications of diabetes. Therefore, this study aimed to assess the prevalence of obesity and to determine the factors that affect obesity in adults with DM.
Methods: This study used a cross-sectional design and included secondary data from the “Cohort Study of Risk Factors for Non-communicable Diseases.” The study was conducted on adults with DM at Kebon Kelapa Village, West Java, in 2017, and the total sample obtained for analysis was 112 respondents.
Results: In this study, 62.5% of adults with DM were overweight or obese (body mass index ≥25 kg/m2). Factors found to influence the incidence of obesity in adults with DM were sex and macronutrient intakes, namely, “over” energy intake, “over” carbohydrate intake, “over” fat intake, and “normal” protein intake. Risk of obesity was 3.15-fold higher in female than male participants with diabetes. The highest risk for increased obesity level in adults with diabetes was found in those with “over” fat intake (odds ratio, 8.33).
Conclusions: In adults with diabetes, the incidence of obesity is a trigger of complications. Therefore, to improve the quality of life of individuals with diabetes, attention must be given to managing their weight.
A STUDY ON CUTANEOUS ADVERSE DRUG REACTIONS REPORTED IN A TERTIARY CARE HOSPITAL, KANCHIPURAM
Authors: PANNEERSELVAM NITHYA , KADHIRVELU PARIMALA , SOMASUNDARAM REVATHI , SOUNDARRAJAN JAYAPRAKASH  
Published: February 2020

Objective: The objective of the study was to study the pattern of various types of cutaneous adverse drug reactions (CADRs) and its relation to therapeutic agents.
Methods: A retrospective study was carried out in the Department of Pharmacology, Meenakshi Medical College Hospital and Research Institute. Pharmacovigilance reports collected from 2017 to 2019 which were probable and certain by the WHO causality assessment were included in the study. Descriptive statistics were used. Values were expressed in numbers and percentage.
Results: Adverse drug reactions (ADRs) of 40 patients were selected based on the inclusion criteria, of which 22 were female (55%) and 18 males (45%). Patients aged <50 years had more incidence (77.5%) of ADRs. Cutaneous manifestations contributed to major ADRs (67.5%). CADRs were more common with antibiotics (55.5%) followed by nonsteroidal anti-inflammatory drugs (14.6%).
Conclusion: The most common therapeutic agent of CADRs were antibiotics (fluoroquinolones and cephalosporins) and the frequent cutaneous manifestation was urticaria.
SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL 3,4-DISUBSTITUTED PYRAZOLE DERIVATIVES
Authors: GANESH AKULA  , KAUSHAL K CHANDRUL  , BHIKSHAPATHI DVRN  
Published: February 2020

Objective: The objective of the current work was to synthesize a series of 3,4-substituted pyrazoles from the cyclization of substituted aryl ethanone and hydrazine hydrate in a two-step process and screen the derivatives for their antimicrobial activity.
Methods: The title compounds were derived from the condensation of ethanone intermediate with N, N-Dimethyl formamide-dimethyl acetal and hydrazine hydrate. Ethanone intermediate synthesized from substituted methyl phenylacetate in the presence of potassium t-butoxide with 6-methyl pyridine-2-carboxylic acid methyl ester.
Results: The final products were characterized by detailed spectral analysis using Mass, Nuclear Magnetic Resonance, and Infra Red spectroscopy. All the compounds (4a-4j) showed significant antibacterial properties on both Gram-positive and Gram-negative bacteria. Interestingly, the selected microbes were found to be highly sensitive for compound 4a, 4c, 4d, 4h, and 4i. The molecules are also antifungal in nature, and they have a significant inhibitory effect on the growth of Candida albicans and Aspergillus niger.
Conclusion: The results suggest that the developed derivatives bearing the pyrazole nucleus could be the lead structures for the development of antimicrobial agents for fatal infections.
QUANTIFICATION OF QUERCETIN AND CHLOROGENIC ACID IN PAPAYA SEED ETHANOL EXTRACT
Authors: RATIH PUSPORINI  , HANAA OMAR BAABDULLAH  , ANDYKA VERU 
Published: February 2020

Objective: The objective of the study was to quantify the quercetin and chlorogenic contained in the ethanolic extract of papaya seed.
Methods: Papaya seeds were extracted using the maceration method; then, the qualitative phytochemical analysis was obtained from standard phytochemical screening; furthermore, liquid chromatography–mass spectrometry (LC–MS) examination was used to determine the number of its bioactive compounds.
Results: The quantitative examination using LC–MS showed that the content of chlorogenic acid was greater than the quercetin level. Further studies have to be carried out regarding the papaya seed ethanolic extract in vitro inhibition compare to the antibacterial potential of the commercial antibiotics on the tested bacteria species.
Conclusion: Our results suggest that papaya seed ethanolic extract quantitatively contains chlorogenic acid greater than quercetin.
Diseño de un portafolio óptimo de suministro eléctrico a partir del modelo de Markowitz: el caso de un usuario en México
Authors: Perea González Alfonso , Zavaleta Vazquez Osmar Hazael 
Published: February 2020

<p>La Reforma Energética de México, promulgada en el año 2013, abrió la posibilidad para que consumidores de energía eléctrica pudieran elegir entre diferentes opciones de suministro. Por lo anterior, el objetivo de este trabajo es validar que el Modelo de Markowitz es útil en la construcción de un portafolio óptimo de suministro de energía eléctrica, a partir de las opciones disponibles en el mercado eléctrico mexicano. Se construyó un caso hipotético, a partir de información real, y los resultados obtenidos en el caso de estudio muestran que el uso de esta metodología permite mitigar los riesgos, a partir de la diversificación de opciones de suministro, tal y como ocurre con la diversificación de alternativas de inversión. Este enfoque constituye una alternativa objetiva para que los usuarios de energía eléctrica planeen y diseñen portafolios óptimos de suministro. <strong></strong></p>
CIMENTOS RESINOSOS
Authors: Spezzia Sérgio 
Published: February 2020

Resumo Cimentos resinosos assemelham-se as resinas compostas e possuem fase inorgânica e orgânica. O componente orgânico é formado por matriz de resina, sendo constituído pelo bisfenol glicidil metacrilato (BIS-GMA) ou pelo uretano di-metacrilato (UDMA) ou pelo Trietileno Glicol Dimetacrilato (TEGDMA). O objetivo do presente artigo foi verificar as propriedades favoráveis do cimento resinoso para emprego nos procedimentos odontológicos. Restaurações indiretas estéticas são bastante utilizadas juntamente com os cimentos resinosos, que são usados visando cimentação estética. O cirurgião dentista deve obter conhecimento acerca das propriedades de cada cimento resinoso que encontra-se disponibilizado para uso, visando selecionar determinado cimento que esteja relacionado com os procedimentos clínicos que serão efetuados. Os cimentos resinosos disponibilizados para uso são muitos e sabe-se que os mesmos diferem quanto a viscosidade; tamanho de suas partículas e forma de polimerização, dentre outras propriedades, podendo optar-se pelo seu uso, dependendo das características intrínsecas aos materiais. Os cimentos resinosos podem ser adquiridos sob forma de pó e líquido; líquidos viscosos e disponibilizados em duas pastas. Pode-se realizar o emprego dos cimentos resinosos em determinadas situações clínicas em que o mesmo encontra-se indicado, como: na cimentação de próteses parciais fixas, que detém estrutura metálica ou que não a possuem; em próteses fixas adesivas e em próteses unitárias. A aplicabilidade clínica dos cimentos resinosos deve obedecer ao planejamento odontológico previamente efetuado, caso sua utilização seja feita de maneira adequada e corretamente indicada, torna-se possível a obtenção de um desfecho protético satisfatório quando da cimentação das restaurações indiretas em boca. Palavras-chave: Protocolos. Planejamento. Viscosidade. Polimerização. Keywords: Protocols. Planning. Viscosity. Polymerization.
IMPLICAÇÕES ODONTOLÓGICAS DO ACOMETIMENTO PELA DOENÇA CELÍACA
Authors: Spezzia Sérgio 
Published: February 2020

Resumo Doença celíaca (DC) consta de desordem inflamatória crônica autoimune, que desencadeia reação autoimune na região do intestino delgado. As modificações ocasionadas pela DC na mucosa do intestino delgado possuem reversibilidade, ao passo que orienta-se os pacientes a não ingerir mais alimentação que contenha o glúten. Deve ser adotada também como medida a averiguação das bulas dos remédios, no intuito de verificar se os mesmos contém traços de glúten em sua fórmula. Existem inúmeros pacientes assintomáticos, o que dificulta a determinação diagnóstica e sabe-se que caso não se proceda ao diagnóstico e ao tratamento da DC em tempo hábil pode haver complicações indesejáveis. O objetivo do presente artigo foi averiguar acerca das manifestações bucais ocorridas em pacientes doentes em decorrência da presença da DC. As principais manifestações orais da DC que podem ocorrer envolvem hipossalivação; glossites; defeitos de esmalte; úlceras aftosas recorrentes; estomatites; aftas; manchas por insuficiência ou por excesso de cálcio, dentre outras. O conhecimento e a conscientização prévia pelos cirurgiões dentistas acerca das repercussões bucais acarretadas pela possível presença da DC em seus pacientes é de fundamental importância para o aprimoramento diagnóstico e para a adoção de condutas odontológicas apropriadas. Palavras-chave: Doença Celíaca. Dieta. Diagnóstico Precoce. Hipoplasia do Esmalte Dentário. Keywords: Celiac Disease. Diet. Early Diagnosis. Dental Enamel Hypoplasia.
Designing Pedagogic Conversational Agents through Data Analysis
Authors: Pérez-Marín Diana , Tamayo-Moreno Silvia 
Published: February 2020

Pedagogical Conversational Agents are systems or programs that represent a resource and a means of learning for students, making the teaching and learning process more enjoyable. The aim is to improve the teaching-learning process. Currently, there are many agents being implemented in multiple knowledge domains. In our previous work, a methodology for designing agents was published, the result of which was Agent Dr. Roland, the first conversational agent for Early Childhood Education. In this paper, we propose the use of Data Analytics techniques to improve the design of the agent. Two new techniques are applied: KDDIAE, application of (Knowledge Discovery in Databases) to the Data of the Interaction between Agents and Students – Estudiantes in Spanish, and BIDAE (use of Data Analytics to obtain information of agents and students). The use of KDDIAE and BIDAE proves the existence of a fruitful relationship between learning analytics and learning design. Some samples of rules related to learning analytics and design are the following: (Learning Analytics) Children who initially do not know how to solve the exercise, after receiving help, are able to understand and solve it à (Learning Design) An agent for small children should be able to provide help. In addition, help should be entertaining and tailored to their characteristics because it is a resource that children actually use; or (Learning Analytics) Younger children use more voice interaction à (Learning Design) An agent interface for young children must incorporate voice commands. A complete list of rules related to learning analytics and design is provided for any researcher interested in PCA design. 72 children were able to use the new Dr. Roland after applying the learning analytics-design rules. They reported a 100 % satisfaction as they all enjoyed interacting with the agent.
Ambientes colaborativos para a produção e o compartilhamento de atividades de aprendizagem: análise dos ambientes WebCollage, LDshake e ILDE
Authors: Scherer Bassani Patrícia , Reis Carla , Henrique Petry de Faria Pedro 
Published: February 2020

Learning Design (LD) ou Design da Aprendizagem é uma área de pesquisa que tem por objetivo tornar mais explícito o processo de desenvolvimento de atividades de aprendizagem com o uso de tecnologias digitais, fomentando o uso de estratégias e de ferramentas para o registro e o compartilhamento dessas atividades. Este estudo, de abordagem qualitativa, teve como objetivo analisar ferramentas para representar e compartilhar atividades de aprendizagem. A pesquisa foi organizada em duas etapas: a) revisão de literatura, para identificar ambientes citados em artigos científicos publicados no periódico Computers & Education entre 2010-2019; b) a análise desses ambientes por meio da observação on-line. Resultados mostram que WebCollage e LDShake foram os ambientes mais citados. Entretanto, eles foram integrados a uma plataforma completa chamada Integrated Learning Design Environment (ILDE).
Ensinando a Identificação de Caracteres Braille utilizando Dispositivos Móveis e um Display Braille
Authors: Hazin da Rocha Victor , Silva Diogo , Boa Vista Maia Bisneto Alvaro , Felipe da Silva Guthemberg , Da Fonseca de Souza Fernando 
Published: February 2020

O número de deficientes visuais no mundo aumentou nos ultimos anos, contudo a taxa de alfabetização dessa parte da população vem caindo consideravelmente. Sendo um dos principais fatores para esse problema, a falta de instrutores aptos a alfabetizar pessoas em Braille. Neste contexto, este artigo apresenta o Braille Reader Tutor, uma aplicação para smartphones e um display Braille open souce, capaz de ensinar a identificação de letras e caracteres Braille, sua correspondência para o alfabeto romano, sem a necessidade de um tutor humano. Diante do exposto, foi feita uma pesquisa com profissionais especialistas em ensino de Braille para a avaliação do método proposto. Por fim, o aplicativo e o display foram desenvolvidos e disponibilizados para avaliação de profissionais responsáveis por afalbetizar deficientes visuais.