bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does local government proliferation reduce maternal mortality? Evidence from Indonesian sub‐national government
Authors: Halimatusa’diyah Iim 
Published: October 2020

AbstractThis study aims to examine the effect of local government proliferation on maternal mortality in Indonesia. Despite the large body of literature on the determinants of local government proliferation, little is known about the consequences of district proliferation on public health services and outcomes. Drawing on in‐depth interviews with local government officials, health providers, and non‐state actors as well as observations of health care provision in four districts in Indonesia, this study reveals that the lack of local state capacity in the newly created districts contributes to higher rates of maternal mortality in the new districts compared to those of old districts. Not only does the lack of state capacity increase the dependency of local government on central government resources, it also discourages the development of local initiatives and policies to reduce maternal mortality.
Diverse sensory cues for individual recognition
Authors: Chung Myung , Wang Mu‐Yun , Huang Ziyan , Okuyama Teruhiro 
Published: October 2020

AbstractTo be social, the ability to recognize and discriminate conspecific individuals is indispensable in social animals, including primates, rodents, birds, fish, and social insects which live in societies or groups. Recent studies using molecular biology, genetics, in vivo and in vitro physiology, and behavioral neuroscientific approaches have provided detailed insights into how animals process and recognize the information of individuals. Here, we review the most distinct sensory modalities for individual recognition in animals, namely, olfaction and vision. In the case of rodents, two polymorphic gene complexes have been identified in their urine as the key and essential pheromonal components for individual recognition: the major histocompatibility complex (MHC) and the major urinary protein (MUP). Animals flexibly utilize MHC and/or MUP, which are detected by the main olfactory epithelium (MOE) and/or the vomeronasal organ (VNO) for various types of social recognition, such as strain recognition, kin recognition, and individual recognition. In contrast, primates, including humans, primarily use facial appearance to identify others. Face recognition in humans and other animals is naturally unique from genetic, cognitive, developmental, and functional points of view. Importantly note that nurture effects during growth phase such as social experience and environment can also shape and tune this special cognitive ability, in order to distinguish subtle differences between individuals. In this review, we address such unique nature and nurture mechanisms for individual recognition.
Recurrent bioprosthetic mitral valve thrombosis treated with anticoagulation
Authors: Fernandes Robin , Varshney Anubodh S. , Aragam Jayashri 
Published: October 2020

AbstractBioprosthetic valve thrombosis (BPVT) is more common than previously thought and likely underreported. BPVT can be accurately diagnosed with cardiac imaging and treated successfully with anticoagulation, thus preventing reoperation. We hereby report a case of recurrent BPVT in the mitral position successfully treated with anticoagulation along with review of literature.
Mastery and Marital Processes: Mechanisms Linking Midlife Economic Adversity and Later‐Life Loneliness for Husbands and Wives in Enduring Marriages
Authors: A. S. Wickrama Kandauda , O’Neal Catherine Walker 
Published: October 2020

AbstractResearch has documented that loneliness is a major public health concern, particularly for older adults in the United States. However, previous studies have not elucidated the mechanisms that connect family economic adversity to husbands’ and wives’ loneliness in later adulthood. Thus, using prospective dyadic data over 27 years from 254 enduring couples, the present study investigated how spouses’ mastery, as an intraindividual process, and marital functioning, as a couple process, link midlife family economic adversity to spouses’ later‐life loneliness. The results provided support for three linking life course pathways: an adversity‐mastery‐loneliness pathway, an adversity‐marital functioning‐loneliness pathway, and a mastery‐marital functioning‐loneliness pathway. The results also showed spousal contemporaneous dependencies in mastery and loneliness. These findings demonstrate the persistent influence of midlife family economic adversity on husbands’ and wives’ loneliness nearly three decades later and elucidate linking mechanisms involving mastery and couple marital functioning. Findings are discussed as they relate to life course and family systems theories. Implications address multiple levels including national‐ and state‐policies and couple‐level clinical interventions.
The macroecology of fish migration
Authors: Alò Dominique , Lacy Shaw Nozaki , Castillo Andrea , Samaniego Horacio A. , Marquet Pablo A. 
Published: October 2020

AbstractAimWe still lack a consensus on the main variables driving changes in migratory strategies. Different hypotheses have been proposed: productivity, energy, environmental heterogeneity, and genetic predisposition. This work takes an integrative view and analyses migrations from a macroecological perspective estimating the extent to which different environmental variables and historic factors influence migratory life histories.LocationGlobal.Time periodCurrent.Major taxa studiedActinopterygian fishes.MethodsUsing public domain museum records, global repositories, and global measures of temperature, productivity, precipitation and heterogeneity, we spatially analysed the distribution of anadromous, catadromous, amphidromous, potamodromous and oceanodromous migratory fish using 1,676 species and compared it to 1,616 non‐migratory fishes. After analysing the individual roles of productivity and temperature in shaping biodiversity, we conducted path analyses including several environmental variables and principal coordinates of phylogenetic structure (PCPS).ResultsThe different migratory strategies are not evenly distributed around the globe and phylogeny is a relevant variable in shaping current patterns. Productivity is positively related to species richness, except for anadromy and potamodromy, for which we observed a unimodal curve. Temperature significantly drives migratory species richness (except for anadromy). The role of environmental heterogeneity, measured as temperature seasonality and annual range, is strongest for anadromous species, which helps explain their skewed distribution towards higher latitudes and why the kinetic energy hypothesis fails in explaining their richness patterns.Main conclusionsOverall, migratory fish richness can be explained by the interaction of multiple variables, such as productivity, temperature, environmental heterogeneity, and the role of phylogeny, but these variables interact differentially in each strategy, diverging most for the anomalous anadromous fishes. Integrating these results into a global framework to better understand the evolutionary and ecological dynamics of migration will help with predicting responses to anthropogenic climate change.
Is air pollution detrimental to regional innovation? Evidence from Chinese cities
Authors: Zhang Min , Chung Seung‐hun 
Published: October 2020

AbstractCould the negative effect of air pollution be a threat to regional innovation and stunt economic growth in the most polluted Chinese cities? Considering that the generation of innovation can greatly rely on skilled workers and their productivity, this paper examines the association between air quality and regional innovation. An instrumental variable for air quality—the central heating policy—is used to address potential endogeneity problems. The results suggest a growing negative and significant impact of air pollution on city‐level innovation. A corresponding mechanism analysis rules out the possibility that self‐selection of skilled workers has accounted for the negative impact of air pollution on innovation and consequently infers that the productivity effects may have explained the negative impact.
Epigenetic modifications in prostate cancer
Authors: Sugiura Masahiro , Sato Hiroaki , Kanesaka Manato , Imamura Yusuke , Sakamoto Shinichi , Ichikawa Tomohiko , Kaneda Atsushi 
Published: October 2020

AbstractProstate cancer is a major cause of cancer‐related deaths among men worldwide. In addition to genomic alterations, epigenetic alterations accumulated in prostate cancer have been elucidated. While aberrant deoxyribonucleic acid hypermethylation in promoter CpG islands inactivates crucial genes associated with deoxyribonucleic acid repair, cell cycle, apoptosis or cell adhesion, aberrant deoxyribonucleic acid hypomethylation can lead to oncogene activation. Acetylation of histone is also deregulated in prostate cancer, which could cause aberrant super‐enhancer formation and activation of genes associated with cancer development. Deregulations of histone methylation, such as an increase of trimethylation at position 27 of histone H3 by enhancer of zeste homolog2 overexpression, or other modifications, such as phosphorylation and ubiquitination, are also involved in prostate cancer development, and inhibitors targeting these epigenomic aberrations might be novel therapeutic strategies. In this review, we provide an overview of epigenetic alterations in the development and progression of prostate cancer, focusing on deoxyribonucleic acid methylation and histone modifications.
Estimation of environmental, genetic and parental age at conception effects on telomere length in a wild mammal
Authors: van Lieshout Sil H. J. , Sparks Alexandra M. , Bretman Amanda , Newman Chris , Buesching Christina D. , Burke Terry , Macdonald David W. , Dugdale Hannah L. 
Published: October 2020

AbstractUnderstanding individual variation in fitness‐related traits requires separating the environmental and genetic determinants. Telomeres are protective caps at the ends of chromosomes that are thought to be a biomarker of senescence as their length predicts mortality risk and reflect the physiological consequences of environmental conditions. The relative contribution of genetic and environmental factors to individual variation in telomere length is, however, unclear, yet important for understanding its evolutionary dynamics. In particular, the evidence for transgenerational effects, in terms of parental age at conception, on telomere length is mixed. Here, we investigate the heritability of telomere length, using the ‘animal model’, and parental age at conception effects on offspring telomere length in a wild population of European badgers (Meles meles). Although we found no heritability of telomere length and low evolvability (<0.001), our power to detect heritability was low and a repeatability of 2% across individual lifetimes provides a low upper limit to ordinary narrow‐sense heritability. However, year (32%) and cohort (3%) explained greater proportions of the phenotypic variance in telomere length, excluding qPCR plate and row variances. There was no support for cross‐sectional or within‐individual parental age at conception effects on offspring telomere length. Our results indicate a lack of transgenerational effects through parental age at conception and a low potential for evolutionary change in telomere length in this population. Instead, we provide evidence that individual variation in telomere length is largely driven by environmental variation in this wild mammal.
Temperature increase and its effects on fish stress physiology in the context of global warming
Authors: Alfonso Sébastien , Gesto Manuel , Sadoul Bastien 
Published: October 2020

AbstractThe capacity of fishes to cope with environmental variation is considered to be a main determinant of their fitness and is partly determined by their stress physiology. By 2100, global ocean temperature is expected to rise by 1–4°C, with potential consequences for stress physiology. Global warming is affecting animal populations worldwide through chronic temperature increases and an increase in the frequency of extreme heatwave events. As ectotherms, fishes are expected to be particularly vulnerable to global warming. Although little information is available about the effects of global warming on stress physiology in nature, multiple studies describe the consequences of temperature increases on stress physiology in controlled laboratory conditions, providing insight into what can be expected in the wild. Chronic temperature increase constitutes a physiological load that can alter the ability of fishes to cope with additional stressors, which might compromise their fitness. In addition, rapid temperature increases are known to induce acute stress responses in fishes and might be of ecological relevance in particular situations. This review summarizes knowledge about effects of temperature increases on the stress physiology of fishes and discusses these in the context of global warming.
The use of muscle lipids and fatty acids to assess shark diet and condition
Authors: Meyer Lauren , Chambers Sherrie , Gervais Connor , Pethybridge Heidi , Beckmann Crystal , Bruce Barry , Huveneers Charlie 
Published: October 2020

AbstractFollowing a lack of detected change in white shark Carcharodon carcharias L. 1758 diet and nutritional condition attributed to the interaction with the cage‐diving industry, Lusseau and Derous (Tourism Management, 2019, 75, 547–549) cautioned the use of muscle lipids and fatty acids in this context, advocating for other biomarkers. This study provides additional evidence from peer‐reviewed literature to contend the usefulness of elasmobranch muscle fatty acid profiles to detail diet and habitat use. It also presents findings from a controlled experiment on captive Port Jackson sharks Heterodontus portusjacksoni (Meyer 1793) whereby long‐term (daily for 33 days) 3 min exhaustive chase exercise changed muscle lipid class profiles, supporting its use to infer nutritional condition after activities such as interactions with wildlife tourism operators. Conversely, the unaltered muscle fatty acid and lipid content suggests their use in trophic ecology is not confounded by activities such as interacting with tourism operators, remaining useful biomarkers to investigate diet and habitat use.
Effect of handling and crowding on the susceptibility of Atlantic salmon (Salmo salar L.) to Lepeophtheirus salmonis (Krøyer) copepodids
Authors: Delfosse Cyril , Pageat Patrick , Lafont‐Lecuelle Céline , Asproni Pietro , Chabaud Camille , Cozzi Alessandro , Bienboire‐Frosini Cécile 
Published: October 2020

AbstractLepeophtheirus salmonis is an ectoparasite causing economic concerns in Atlantic salmon farming. Salmon lice infestation management methods can be stressful and impact fish welfare. This work investigated the stress effect on the attachment of L. salmonis copepodids to Atlantic salmon through two approaches: (a) handling by netting and air exposure (acute stress), and (b) crowding with restricted surface access in a tank (chronic stress). In the first experiment, we compared the number of attached L. salmonis and cortisol levels between a group of handled salmon and a control group. In the second experiment, a group of densely packed salmon was compared to a control group based on the number of attached copepodids, cortisol levels and neutrophil:lymphocyte ratios. Handled salmon showed significantly higher plasma cortisol levels (p < .001) and more attached copepodids (p = .01) than control salmon. Conversely, the cortisol level and number of attached copepodids were not significantly different between the densely packed and control salmon (p > .05). The neutrophil:lymphocyte ratio was significantly higher (p = .0014) in the densely packed salmon than in the control salmon. Handling salmon increased their risk of infestation by L. salmonis. This has implications for reinfestation rates following delousing treatments in commercial salmon aquaculture, which often involve crowding and handling salmon.
Comparative bioavailability of enrofloxacin in dogs when concealed in noncommercial morsels, either as tablet or as enrofloxacin–alginate dried beads
Authors: Gutierrez Lilia , Lechuga Teresa , Marcos Xelhua , García‐Guzmán Perla , Gutrierrez Carlos , Sumano Hector 
Published: October 2020

AbstractAdministration of enrofloxacin tablets concealed in improvised morsels to elude the unpleasant flavor of this drug is likely to diminish maximum plasma concentrations (Cmax) reached by this drug, jeopardizing treatment efficacy. To avoid this, the hypothesis that alginate dried beads containing enrofloxacin (ADBE) could modify the pharmacokinetics of enrofloxacin in dogs was tested. ADBE were manufactured and pharmaceutically defined as having high entrapment efficiency (>90%) and a drug loading capacity of 56%–67%. Based on the hydrophilic nature of alginate and its interaction with the anionic charge of the amino groups of enrofloxacin, a novel modified release system was obtained in which ADBE give place to both a rapid diffusion releasing of enrofloxacin and a maintained release. The ADBE concealed in a sausage (ADBEs) achieved both the highest Cmax (5.1 µg/ml ± 0.3 SD) and the area under the concentration versus time (AUC0–24) (41.2 µg hr−1 ml−1 ± 6.9 SD). The tablet administered alone had a Cmax of 1.9 µg/ml ± 0.3 SD and an AUC0–24 = 16.5 µg h−1 ml−1 ± 3.5 SD, while the tablet concealed in a sausage reached a Cmax of 1.2 µg/ml ± 0.3 SD with an AUC0–24 = 12.3 µg hr−1 ml−1 ± 3.8 SD (p < .05 in both cases when confronting ADBEs vs. tablets). Consequently, Cmax/MIC and AUC0–24/MIC ratios are higher for ADBEs. Other PK parameters were statistically indistinguishable, and other morsels containing enrofloxacin as a tablet or as ADBE rendered less favorable PK parameters. Due to ease of administration and favorable PK for ADBE concealed in a sausage, this pharmaceutical design can be regarded as PK/PD consistent and worthy of clinical studies.
Optimising intermittent fasting: Evaluating the behavioural and metabolic effects of extended morning and evening fasting
Authors: Clayton D. J. , Mode W. J. A. , Slater T. 
Published: October 2020

AbstractThis article describes the aims of a new study funded by the British Nutrition Foundation Drummond Pump Priming Award. This study will explore the independent metabolic, endocrinal and behavioural effects of extended morning and evening fasting. In an obesogenic society, there is an urgent need to identify effective strategies for preventing obesity‐related diseases, such as type 2 diabetes. Implementing extended periods of fasting and restricted time permitted for food intake may be an efficacious method for weight management and improving metabolic health. However, recent research suggests that the success of this intervention may be influenced by when the fasting window occurs, with evening fasting appearing to elicit superior metabolic benefits compared to morning fasting. The mechanisms driving these time‐dependent outcomes are not yet clear but may be due to circadian variations in metabolic physiology and in behaviours known to influence energy balance. To date, no study has directly compared the acute metabolic and behavioural responses to morning and evening fasting with those of a control trial. Research on evening fasting is also currently restricted to individuals living with overweight or obesity, emphasising a need for research in lean individuals aiming to maintain a healthy bodyweight and improve metabolic health. This article highlights the need for alternative nutritional interventions to improve public health, before reviewing the existing literature linking extended fasting, circadian rhythms and behavioural and metabolic outcomes. The final part of this article outlines the aims, methodology and intended outcomes of the current research project.
Therapeutic Effect of Acetabular Fractures Using the Pararectus Approach Combined with 3D Printing Technique
Authors: Zou Ruyi , Wu Min , Guan Jianzhong , Xiao Yuzhou , Chen Xiaotian 
Published: October 2020

ObjectiveTo explore the clinical efficacy of pararectus approach combined with 3D printing technique for the surgical treatment of partial acetabular fractures.MethodsWe retrospectively evaluated 33 (20 males and 13 females) patients with acetabular fractures in the period of June 2017 to December 2018. According to Judet and Letournel classification: 11 cases were of anterior column fracture, 10 cases were of double column fracture, seven fractures were of the anterior column with posterior half transverse, three fractures were of transverse fracture, and two cases were of “T” fracture. For all cases, 3D printing is used to print the acetabular model. Pre‐bent reconstruction plates from the model were placed to fixate fractures via the pararectus approach.ResultsThirty‐three patients (mean age 48 years; range, 35–63 years), included 20 men and 13 women, were treated successfully with open reduction and internal fixation by the pararectus approach. Surgery duration was 203 min on average (range: 135–245 min), and intra‐operative bleeding was 1030 mL on average (range: 450–1400 mL). All patients were followed‐up for 12–18 months (average,14 months); two patients (6.0%) developed postoperative ossifying myositis, and there are no obvious symptoms at present; one patient (3.0%) developed postoperative wound infection, and the wound completely improved by secretion culture, enhanced dressing, and effective antibiotics; all the acetabular fractures united after 12 to 16 weeks (average,13 weeks). According to the modified Merle d'Aubigne and Postel scoring system to assess the hip function: excellent in 22 cases (66.7%), good in seven cases (21.2%), and fair in four cases (12.1%).ConclusionsIn the treatment of partial acetabular fractures, the pararectus approach combined with 3D printing technique can achieve effective reduction and fixation, decrease intraoperative hemorrhage, shorten operation time, and the internal fixation position can be properly adjusted during the operation by looking directly at the model.
Effect of Patellar Denervation on Anterior Knee Pain and Knee Function in Total Knee Arthroplasty without Patellar Resurfacing: A Meta‐Analysis of Randomized Controlled Trials
Authors: Wang Yuhang , Feng Wei , Zang Junting , Gao Hang 
Published: October 2020

ObjectiveThe aim of the present study was to evaluate the effect of patellar denervation (PD) in preventing anterior knee pain (AKP) and improving knee function after total knee arthroplasty (TKA) without patellar resurfacing, and to help surgeons decide whether or not to use PD in TKA.MethodsThe electronic databases of Pubmed, Embase, Cochrane, Web of Science, and Scopus were searched for all randomized controlled trials (RCT) comparing the outcomes of PD and no patellar denervation (NPD) in TKA without patellar resurfacing. Primary outcomes were incidence of AKP, visual analogue scale for pain (VAS), and patellar score (PS). Secondary outcomes were Knee Society Score (KSS), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the Oxford Knee Score (OKS), knee range of motion (ROM), and complications.ResultsA total of nine RCT met the inclusion criteria. On meta‐analysis, PD significantly reduced the incidence of AKP (odds ratio 0.49; 95% confidence interval [CI] 0.26 to 0.92), reduced the VAS (weighted mean difference [WMD] −0.57; 95% CI −1.02 to −0.11), and improved the WOMAC (WMD −4.63; 95% CI −6.49 to −2.77) and the ROM (WMD 9.60; 95% CI 0.39 to 18.81) during the follow‐up within 12 months. In addition, PD improved the PS (WMD 1.01; 95% CI 0.65 to 1.38), KSS (WMD 1.12; 95% CI 0.10 to 2.14), and the WOMAC (WMD −1.41; 95% CI −2.74 to −0.08) during the follow‐up after 12 months.ConclusionPatellar denervation could significantly reduce the VAS and the incidence of AKP in the early stages after TKA as well as improve the clinical outcomes in terms of the PS, the WOMAC, the KSS, and the ROM. This study demonstrates that PD is a safe and recommendable technique that could be routinely performed in TKA.