bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-agent ibrutinib in RESONATE-2™ and RESONATE™ versus treatments in the real-world PHEDRA databases for patients with chronic lymphocytic leukemia
Authors: Salles Gilles , Bachy Emmanuel , Smolej Lukas , Simkovic Martin , Baseggio Lucile , Panovska Anna , Besson Hervé , Healy Nollaig , Garside Jamie , Iraqi Wafae , Diels Joris , Pick-Lauer Corinna , Spacek Martin , Urbanova Renata , Lysak Daniel , Hermans Ruben , Lundbom Jessica , Callet-Bauchu Evelyne , Doubek Michael 
Published: November 2019

AbstractAfter analyzing treatment patterns in chronic lymphocytic leukemia (CLL) (objective 1), we investigated the relative effectiveness of ibrutinib versus other commonly used treatments (objective 2) in patients with treatment-naïve and relapsed/refractory CLL, comparing patient-level data from two randomized registration trials with two real-world databases. Hazard ratios (HR) and 95% confidence intervals (CIs) were estimated using a multivariate Cox proportional hazards model, adjusted for differences in baseline characteristics. Rituximab-containing regimens were often prescribed in clinical practice. The most frequently prescribed regimens were fludarabine + cyclophosphamide + rituximab (FCR, 29.3%), bendamustine + rituximab (BR, 17.7%), and other rituximab-containing regimens (22.0%) in the treatment-naïve setting (n = 604), other non-FCR/BR rituximab-containing regimens (38.7%) and non-rituximab–containing regimens (28.5%) in the relapsed/refractory setting (n = 945). Adjusted HRs (95% CI) for progression-free survival (PFS) and overall survival (OS), respectively, with ibrutinib versus real-world regimens were 0.23 (0.14–0.37; p < 0.0001) and 0.40 (0.22–0.76; p = 0.0048) in the treatment-naïve setting, and 0.21 (0.16–0.27; p < 0.0001) and 0.29 (0.21–0.41; p < 0.0001) in the relapsed/refractory setting. When comparing real-world use of ibrutinib (n = 53) versus other real-world regimens in relapsed/refractory CLL (objective 3), adjusted HRs (95% CI) were 0.37 (0.22–0.63; p = 0.0003) for PFS and 0.53 (0.27–1.03; p < 0.0624) for OS. This adjusted analysis, based on nonrandomized patient data, suggests ibrutinib to be more effective than other commonly used regimens for CLL.
Influence of a thin amorphous surface layer on de-channeling during aluminum implantation at different temperatures into 4H-SiC
Authors: Linnarsson M. K. , Hallén A. , Vines L. 
Published: November 2019

AbstractIon implantation is an important technique in semiconductor processing and has become a key technology for 4H-SiC devices. Today, aluminum (Al) implantations are routinely used for p-type contacts, p+-emitters, terminations and many other applications. However, in all crystalline materials, quite a few ions find a path along a crystal channel, so-called channeling, and these ions travel deep into the crystal. This paper reports on the channeling phenomenon during Al implantation into 4H-SiC, and in particular, the influence of a thin native oxide will be discussed in detail. The effects of thermal lattice vibrations for implantations performed at elevated temperatures will also be elucidated. 100 keV Al ions have been implanted along the [000-1] direction employing samples with 4° miscut. Before implantation, the samples have been aligned using the blocking pattern of backscattered protons. Secondary ion mass spectrometry has been used to record the Al depth distribution. To predict implantation profiles and improve understanding of the role of crystal structure, simulations were performed using the Monte-Carlo binary collision approximation code SIIMPL. Our results show that a thin surface layer of native oxide, less than 1 nm, has a decisive role for de-channeling of aligned implantations. Further, as expected, for implantations at elevated temperatures, a larger degree of de-channeling from major axes is present due to increased thermal vibrations and the penetration depth of channeled aluminum ions is reduced. The values for the mean-square atomic displacements at elevated temperatures have been extracted from experimental depth profiles in combination with simulations.
Transcriptome analysis reveals overlap in fusion genes in a phase I clinical cohort of TNBC and HGSOC patients treated with buparlisib and olaparib
Authors: Eismann Julia , Heng Yujing J. , Waldschmidt Johannes M. , Vlachos Ioannis S. , Gray Kathryn P. , Matulonis Ursula A. , Konstantinopoulos Panagiotis A. , Murphy Charles J. , Nabavi Sheida , Wulf Gerburg M. 
Published: November 2019

Abstract
Purpose
Fusion genes can be therapeutically relevant if they result in constitutive activation of oncogenes or repression of tumor suppressors. However, the prevalence and role of fusion genes in female cancers remain largely unexplored. Here, we investigate the fusion gene landscape in triple-negative breast cancer (TNBC) and high-grade serous ovarian cancer (HGSOC), two subtypes of female cancers with high molecular similarity but limited treatment options at present.

Methods
RNA-seq was utilized to identify fusion genes in a cohort of 18 TNBC and HGSOC patients treated with the PI3K inhibitor buparlisib and the PARP inhibitor olaparib in a phase I clinical trial (NCT01623349). Differential gene expression analysis was performed to assess the function of fusion genes in silico. Finally, these findings were correlated with the reported clinical outcomes.

Results
A total of 156 fusion genes was detected, whereof 44/156 (28%) events occurred in more than one patient. Low recurrence across samples indicated that the majority of fusion genes were private passenger events. The long non-coding RNA MALAT1 was involved in 97/156 (62%) fusion genes, followed in prevalence by MUC16, FOXP1, WWOX and XIST. Gene expression of FOXP1 was significantly elevated in patients with vs. without FOXP1 fusion (P= 0.02). From a clinical perspective, FOXP1 fusions were associated with a favorable overall survival.

Conclusions
In summary, this study provides the first characterization of fusion genes in a cohort of TNBC and HGSOC patients. An improved mechanistic understanding of fusion genes will support the future identification of innovative therapeutic approaches for these challenging diseases.
Sexual dimorphism in gastric cancer: tumor-associated neutrophils predict patient outcome only for women
Authors: Clausen Franziska , Behrens Hans-Michael , Krüger Sandra , Röcken Christoph 
Published: November 2019

Abstract
Purpose
Tumor-associated neutrophils (TANs) are part of the tumor immune microenvironment (TIME) and may contribute to gastric cancer (GC) biology. We hypothesized that TAN are enriched in the TIME, show sex-specific differences, and correlate with patient outcome.

Methods
We analyzed the distribution and putative tumor biological significance of TANs in a well-characterized, therapy-naïve, European GC cohort using immunohistochemical staining of myeloperoxidase (MPO), and digital image analysis using Definiens Tissue Studio®.

Results
Different tumor compartments were examined, and TAN densities were correlated with various clinicopathological patient characteristics. TAN density showed a large interindividual variability ranging from 0 to 6711.0 TANs/mm2. Intratumoral distribution patterns were inhomogeneous (tumor surface vs. tumor center vs. invasion front) and correlated significantly with Laurén phenotype, tumor grade, and microsatellite status in the tumor center and invasion front. In the multivariate analysis, TAN density in the invasion front was an independent predictor of tumor-specific survival only for women (HR = 2.77, p   < 0.001). In men, no correlation was found between TAN density and survival.

Conclusion
With regard to TANs, our study independently validates sexual dimorphism in GC biology.
Selecting the optimal risk threshold of diabetes risk scores to identify high-risk individuals for diabetes prevention: a cost-effectiveness analysis
Authors: Mühlenbruch Kristin , Zhuo Xiaohui , Bardenheier Barbara , Shao Hui , Laxy Michael , Icks Andrea , Zhang Ping , Gregg Edward W. , Schulze Matthias B. 
Published: November 2019

AbstractAimsAlthough risk scores to predict type 2 diabetes exist, cost-effectiveness of risk thresholds to target prevention interventions are unknown. We applied cost-effectiveness analysis to identify optimal thresholds of predicted risk to target a low-cost community-based intervention in the USA.MethodsWe used a validated Markov-based type 2 diabetes simulation model to evaluate the lifetime cost-effectiveness of alternative thresholds of diabetes risk. Population characteristics for the model were obtained from NHANES 2001–2004 and incidence rates and performance of two noninvasive diabetes risk scores (German diabetes risk score, GDRS, and ARIC 2009 score) were determined in the ARIC and Cardiovascular Health Study (CHS). Incremental cost-effectiveness ratios (ICERs) were calculated for increasing risk score thresholds. Two scenarios were assumed: 1-stage (risk score only) and 2-stage (risk score plus fasting plasma glucose (FPG) test (threshold 100 mg/dl) in the high-risk group).ResultsIn ARIC and CHS combined, the area under the receiver operating characteristic curve for the GDRS and the ARIC 2009 score were 0.691 (0.677–0.704) and 0.720 (0.707–0.732), respectively. The optimal threshold of predicted diabetes risk (ICER < $50,000/QALY gained in case of intervention in those above the threshold) was 7% for the GDRS and 9% for the ARIC 2009 score. In the 2-stage scenario, ICERs for all cutoffs ≥ 5% were below $50,000/QALY gained.ConclusionsIntervening in those with ≥ 7% diabetes risk based on the GDRS or ≥ 9% on the ARIC 2009 score would be cost-effective. A risk score threshold ≥ 5% together with elevated FPG would also allow targeting interventions cost-effectively.
Dynamic response of RNA editing to temperature in grape by RNA deep sequencing
Authors: Zhang Aidi , Jiang Xiaohan , Zhang Fuping , Wang Tengfei , Zhang Xiujun 
Published: November 2019

AbstractRNA editing is a post-transcriptional process of modifying genetic information on RNA molecules, which provides cells an additional level of gene expression regulation. Unlike mammals, in land plants, RNA editing converts C-to-U residues in organelles. However, its potential roles in response to different stressors (heat, salt, and so on) remains unclear. Grape is one of the most popular and economically important fruits in the world, and its production, like other crops, must deal with abiotic and biotic stresses, which cause reductions in yield and fruit quality. In our study, we tested the influence of the environmental factor temperature on RNA editing process in the whole mRNA from grape organelle. In total, we identified 122 and 627 RNA editing sites in chloroplast and mitochondria respectively with the average editing efficiency nearly ~ 60%. The analyses revealed that number of non-synonymous editing sites were higher than that of synonymous editing sites, and the amino acid substitution type tends to be hydrophobic. Additionally, the overall editing level decreased with the temperature rises, especially for several gene transcripts in chloroplast and mitochondria (matK, ndhB, etc.). We also found that the expression level of most PPR genes decreased with the temperature rises, which may contribute to the decline of RNA editing efficiency at high temperature. Our findings suggested that the RNA editing events were very sensitive to heat stress; the changes of amino acid in RNA editing genes may contribute to the stress adaption for grape.
End-of-life vehicle management: a comprehensive review
Authors: Karagoz Selman , Aydin Nezir , Simic Vladimir 
Published: November 2019

AbstractWaste management is gaining very high importance in recent years. As automotive is one of the most critical sectors worldwide, which is rapidly increasing, the management of end-of-life vehicles (ELVs) gains importance day by day. Due to legislation and new regulations, actors like users, producers, and treatment facilities are being conferred new responsibilities in the ELV management process. Besides, the ELV management is of vital importance for environment conservation, circular economy and sustainable development. All of these reasons are making the ELV management such a crucial issue to study. Today, the ELV management is a well-positioned and emergent research area. However, the available review papers are focused only on a small area of the ELV management, such as reverse logistics, recovery infrastructure, disassemblability, etc. Besides, a review of state-of-the-art mathematical models for the ELV management is still missing. This paper aims to provide an extensive content analysis overview of studies on the ELV management. A total of 232 studies published in the period 2000–2019 are collected, categorized, reviewed and analyzed. A critical review of the published literature is provided. Gaps in the literature are identified to clarify and suggest future research directions. This review can provide a source of references, valuable insights, and opportunities for researchers interested in the ELV management and inspire their additional attention.
Remote monitoring of chronic heart failure patients: invasive versus non-invasive tools for optimising patient management
Authors: Veenis J. F. , Brugts J. J. 
Published: November 2019

AbstractExacerbations of chronic heart failure (HF) with the necessity for hospitalisation impact hospital resources significantly. Despite all of the achievements in medical management and non-pharmacological therapy that improve the outcome in HF, new strategies are needed to prevent HF-related hospitalisations by keeping stable HF patients out of the hospital and focusing resources on unstable HF patients. Remote monitoring of these patients could provide the physicians with an additional tool to intervene adequately and promptly. Results of telemonitoring to date are inconsistent, especially those of telemonitoring with traditional non-haemodynamic parameters. Recently, the CardioMEMS device (Abbott Inc., Atlanta, GA, USA), an implantable haemodynamic remote monitoring sensor, has shown promising results in preventing HF-related hospitalisations in chronic HF patients hospitalised in the previous year and in New York Heart Association functional class III in the United States. This review provides an overview of the available evidence on remote monitoring in chronic HF patients and future perspectives for the efficacy and cost-effectiveness of these strategies.
Situated transformations of women and gender relations in small-scale fisheries and communities in a globalized world
Authors: Frangoudes Katia , Gerrard Siri , Kleiber Danika 
Published: November 2019

AbstractThe need to uncover, interrogate, and integrate women’s contributions to fisheries in research and development has never been clearer. As coastal and fisheries management continues to look to the Sustainable Development Goals and the Voluntary Guidelines for Securing Sustainable Small-Scale Fisheries in the context of Food Security and Poverty Eradication, as frameworks and mandates, gender equity and equality have become a central concern. To fill the still existing gap of documentation and theoretical engagement, in this thematic collection, we gather together voices from researchers and practitioners from around the world, with one overarching common approach of using a gender lens to examine the relationship between humans and aquatic resources. Drawing on Donna Haraway’s classic feminist concept of situated knowledges, we examine the many and varied approaches researchers are using to engage with the intersection of gender and fisheries. Beginning and ending with two reviews that examine where gender and fisheries has come from, and where it is going, this thematic issue includes case studies from 10 countries, engaging in the topic at various scales (individual, household, national, institutional etc.), and using multiple methodological approaches. Taken together, these pieces explore the mechanism by which women’s contribution to fisheries are overlooked and provide direct evidence to contest the persistent invisibility of women in fishing, fisheries labor, and fisheries decision-making. Going beyond the evidence of women’s contributions, the authors go further to examine different coastal contexts, intersectional identities such as age, and explore gender transformative approaches to fisheries development.
Prevalence of anemia and iron profile among children and adolescent with low socio-economic status
Authors: Andriastuti Murti , Ilmana Ganda , Nawangwulan Serra Avilia , Kosasih Kartika Anastasia 
Published: November 2019

Background:
A national health survey in Indonesia conducted in 2013 showed that the prevalence of anemia in school-aged children and adolescents tripled from a survey conducted in 2007. Children and adolescents are particularly susceptible to iron deficiency anemia (IDA) and iron deficiency (ID) because of their rapid growth and puberty. Teenage girls are at risk because of their menstrual bleeding. Low socioeconomic status in children and adolescents is also a strong risk factor for experiencing iron defi­ciency. Studies regarding the prevalence of ID and IDA in Indonesia still vary and are lacking. This study aims to describe the prevalence of anemia in children and adolescents with low socioeconomic conditions.

Methods:
This is a cross-sectional study conducted at two schools in the suburbs of Jakarta on children and adolescents aged 6–18 years old. Personal data and laboratory identities (complete peripheral blood count, reticulocyte hemoglobin content, ferritin, transferrin saturation, and C-reactive protein) were collected to determine iron status. Analysis was performed using SPSS program version 22.0.

Results:
The overall prevalence of anemia was 14.0%. The prevalence of IDA, ID without anemia, and iron depletion was 5.8%, 18.4%, and 4.3%, respectively. The prevalence of IDA, ID, and iron depletion was higher in females than in males.

Conclusion:
The overall prevalence of anemia in children and adolescents is lower than the national data. Special consideration needs to be taken for the female population, who are more at risk of developing ID and IDA.
Employability Assessment in Australian Total and Permanent Disability Insurance Claims: A Survey of Claims Professionals’ Views
Authors: Black Margaret , Matthews Lynda R. , Millington Michael J. 
Published: November 2019

Abstract
Employability assessment was developed to help claims professionals decide total and permanent disability insurance claims, yet it has not been empirically evaluated. This descriptive study sought formative knowledge about employability assessment from claims professionals working in the multibillion-dollar Australian life insurance total and permanent disability market. Claims assessors (n = 53) and technical advisors (n = 51) responded to a nationwide online survey. Participants found employability assessment was cost effective and very useful in deciding claims. Having an objective, realistic, and clear picture of a claimant’s employment prospects was important. Highly rated components of employability assessment included transferable skills analysis; summary of education, training and experience; job match rationale; and labour market analysis with employer contact. Face-to-face claimant interviews were favoured by 56% of participants, particularly when there was legal involvement. Standardised provider training and certification were recommended to improve report quality and withstand scrutiny of the courts. Billing time estimates are higher than extant costs for assessment tasks. More than half (56%) the participants considered rehabilitation counsellors were best qualified to conduct employability assessments. The study findings contribute new knowledge to this emergent field and point to further research into quality and cost of employability assessment, and provider accreditation.
KMS states on theC*-algebras of Fell bundles over groupoids
Authors: AFSAR ZAHRA , SIMS AIDAN 
Published: November 2019

AbstractWe consider fibrewise singly generated Fell bundles over étale groupoids. Given a continuous real-valued 1-cocycle on the groupoid, there is a natural dynamics on the cross-sectional algebra of the Fell bundle. We study the Kubo–Martin–Schwinger equilibrium states for this dynamics. Following work of Neshveyev on equilibrium states on groupoidC*-algebras, we describe the equilibrium states of the cross-sectional algebra in terms of measurable fields of states on theC*-algebras of the restrictions of the Fell bundle to the isotropy subgroups of the groupoid. As a special case, we obtain a description of the trace space of the cross-sectional algebra. We apply our result to generalise Neshveyev’s main theorem to twisted groupoidC*-algebras, and then apply this to twistedC*-algebras of strongly connected finitek-graphs.
Causes of Oceanic Crustal Thickness Oscillations Along a 74‐M Mid‐Atlantic Ridge Flow Line
Authors: Shinevar William J. , Mark Hannah F. , Clerc Fiona , Codillo Emmanuel A. , Gong Jianhua , Olive Jean‐Arthur , Brown Stephanie M. , Smalls Paris T. , Liao Yang , Le Roux Véronique , Behn Mark D. 
Published: November 2019

AbstractGravity, magnetic, and bathymetry data collected along a continuous 1,400‐km‐long spreading‐parallel flow line across the Mid‐Atlantic Ridge indicate significant tectonic and magmatic fluctuations in the formation of oceanic crust over a range of time scales. The transect spans from 28 Ma on the African Plate to 74 Ma on the North American plate, crossing the Mid‐Atlantic Ridge at 35.8°N. Gravity‐derived crustal thicknesses vary from 3–9 km with a standard deviation of 1.0 km. Spectral analysis of bathymetry and residual mantle Bouguer anomaly show a diffuse power at >1 Myr and concurrent peaks at 390, 550, and 950 kyr. Large‐scale (>10 km) mantle thermal and compositional heterogeneities, variations in upper mantle flow, and detachment faulting likely generate the >1 Myr diffuse power. The 550‐ and 950‐kyr peaks may reflect the presence of magma solitons and/or regularly spaced ~7.7 and 13.3 km short‐wavelength mantle compositional heterogeneities. The 390‐kyr spectral peak corresponds to the characteristic spacing of faults along the flow line. Fault spacing also varies over longer periods (>10 Myr), which we interpret as reflecting long‐lived changes in the fraction of tectonically versus magmatically accommodated extensional strain. A newly discovered off‐axis oceanic core complex (Kafka Dome) found at 8 Ma on the African plate further suggests extended time periods of tectonically‐dominated plate separation. Fault spacing negatively correlates with gravity‐derived crustal thickness, supporting a strong link between magma input and fault style at mid‐ocean ridges.