bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel nomogram for predicting survival in patients with severe acute pancreatitis: an analysis based on the large MIMIC-III clinical database
Authors: Han Di di , Xu Shuo Feng , Li Zhuo Cheng , Zhang Ming Lu , Yang Rui , Zheng Shuai , Wang Chen Zi , Lyu Jun 
Published: December 2020

Abstract
Background Severe acute pancreatitis (SAP) can cause various complications. Septic shock is a relatively common and serious complication that causes uncontrolled systemic inflammatory response syndrome, which is one of the main causes of death. This study aimed to develop a nomogram for predicting the overall survival of SAP patients during the initial 24 hours following admission. Materials and Methods All data utilized in this study were obtained from the MIMIC-III (Medical Information Mart for Intensive Care III) database. The data were analyzed using multivariate Cox regression, and the performance of the proposed nomogram was evaluated based on Harrell’s concordance index (C-index) and the area under the receiver operating characteristic curve(AUC). The clinical value of the prediction model was tested using decision-curve analysis (DCA). The primary outcomes were 28-day,60-day, and 90-day mortality rates. Results The 850 patients included in the analysis comprised 595 in the training cohort and 255 in the validation cohort. The training cohort consisted of 353 (59.3%) males and 242 (40.7%) females with SAP. Multivariate Cox regression showed that weight, sex, insurance status, explicit sepsis, SAPSII score, Elixhauser score, bilirubin, anion gap, creatinine, hematocrit, hemoglobin, RDW, SpO 2 , and respiratory rate were independent prognostic factors for the survival of SAP patients admitted to an intensive care unit. The predicted values were compared using C-indexes, calibration plots, integrated discrimination improvement, net reclassification improvement, and DCA. Conclusions We have identified some important demographic and laboratory parameters related to the prognosis of patients with SAP, and have used them to establish a more accurate and convenient nomogram for evaluating their 28-day, 60-day, and 90-day all-cause mortality rates. The prognostic value of the novel nomogram is superior to that of the traditional SAPSII scoring system alone.
A More Efficient Observation Way With Electric Dipole Sources
Authors: wang xianxiang , Chang yongbang , Deng Juzhi 
Published: December 2020

Abstract
The Ex and Hz amplitude are monotonic functions of the resistivity, and numerical algorithm can be utilized to obtain the high-precision apparent resistivity for all frequencies. On this basis, we focus on the comparative analysis of the resolution for Ex field, Hz field, and Cagniard apparent resistivity to conductive and resistance targets, which proves that the Ex field may have a better resolution for the resistance bodies, and the Hz field can better identify the conductive target. Besides, the electromagnetic data is often distorted by the static effect, which seriously affects the application effect of the electromagnetic method. The influence of the static effect on the Ex field, Hz field, is also analyzed. The apparent resistivity based on the Ex field and Cagniard apparent resistivity are severely affected by the static effect which can cover deep anomalous bodies, but the apparent resistivity based on the Hz field is almost unaffected by the static effect. At last, a more efficient observation way is provided for the resistance and conductive targets, respectively.
Identification of Biomarkers and Study of Mechanisms Related to Metastatic of Osteosarcoma Based on Integrated Bioinformatics Analyses
Authors: Wu Guangzhi , Zhang Minglei 
Published: December 2020

Abstract
BackgroundOsteosarcoma (OS) is a serious threat to public health. Because of high morbidity and fairly complicated pathogenesis. The study aim to identify candidate biomarkers and research the molecular mechanisms correlated of patients with metastatic OS. MethodsThe GSE21257 was downloaded from Gene Expression Omnibus(GEO) database, and the differentially expressed RNAs (DERs) were identified and functional enriched analysis by statistical soft-ware in R. Subsequently, the co-expression modules and its clinical characteristics of OS were identified by weighted gene co-expression network analysis (WGCNA) Following, the KEGG pathways directly related to metastatic OS was to researched by the Comparative Toxicogenomics Database 2019 update (CTD). Finally, the “survival” package in R was used to survival analysis and the DERs were verified using another independent profiling GSE14827. ResultsA total of 1,464 DERs were classified including 702 up-regulated and 762 down-regulated. In addition, a total of 1248 DERs were obtained by WGCNA analysis, the blue modules is the highest negative correlation (P=0) and the turquoise modules is highest positive correlation (P=3E-196) among all correlations with OS metastatic. The lncRNA-mRNA co-expression network including 4 lncRNAs and 507 mRNAs, and the cytokine-cytokine receptor interaction and JAK-STAT signaling pathway were found significantly correlation with metastatic. Finally, the increased expression levels of IFNGR1, lower DLEU1 and DLEU2 related to better prognosis. Which were significantly consistent in the another independent profiling GSE14827. ConclusionsA bioinformatics analysis related to the IFNGR1, DLEU1 and DLEU2 may as candidate biomarkers for metastatic OS.
The Construct and Predictive Validity Testing of Indonesian Entrepreneurial Competence Inventory-Situational Judgment Test Model (Long Version)
Authors: Riyanti Benedicta Prihatin Dwi , Suryani Angela Oktavia , Sandroto Christine Winstinindah , Soeharso Silverius Y. 
Published: December 2020

Abstract
This research aimed to test the internal and external validity of the Indonesian Entrepreneurial Competence Inventory that was constructed based on situational judgment test (SJT) model. Spencer’s entrepreneurial competence theory and interviews with entrepreneurs were employed to build the items. The internal construct validity was tested by applying confirmatory factor analysis (CFA), while the external construct validity was tested by implementing correlations with other tests that were theoretically correlate with entrepreneurial competency, namely the previous entrepreneurial competence (Likert-scale model) and risk behaviour. The predictive validity was analysed by using correlation testing with an instrument assessing balance scorecard measurement of entrepreneurial achievement. A sample of 149 entrepreneurs from industrial cities in Indonesia was recruited via convenience sampling. The CFA analyses showed that nine dimensions of the Indonesian Entrepreneurial Competences Inventory were valid. In the correlation testing with risk taking behaviour and business success, all of the dimensions were significantly valid, except the see and act on opportunity dimension. However, in the correlation with the previous entrepreneurial competence scale, the significant correlation was found only with commitment to work. In further analysis, the correlation between dimensions of the current inventory and dimensions of the previous scale showed that the significant correlations were found between competence of seeing opportunity and commitment to work, assertiveness, and persuasion. The impact to the future research and practice application were discussed.
Factors Associated With Risky Sexual Behaviour Amongst Students at a Training College in Limpopo Province, South Africa
Authors: Murudi-Manganye Nthuseni Sharon , Mashau Ntsieni , Ramathuba Dorah 
Published: December 2020

Abstract
Background: Globally students who attend colleges indulge in risky sexual practices which in turn expose them to sexually transmitted infections. Risky sexual practices such as multiple sexual partners, unprotected sex, and transactional sex continue to pose risks of sexual transmitted infections, unwanted pregnancy as well as increased termination of pregnancy amongst young people. Engaging in risky sexual behaviour is associated with various factors. Therefore, the reported study was aimed at describing the factors associated with risky sexual behaviour amongst students at a training college in South Africa. Methods: The study adopted a quantitative, cross-sectional descriptive design to describe factors associated with risky sexual behaviour amongst students. Data was collected through a self-administered questionnaire among 307 students who were random sampled. The Statistical Package for Social Sciences version 23.0 was used to analyse data. Results: Among the respondents, 70,7% were females and 29.3% were males. Majority of the respondents 51.2% were staying at a rental place and about 49% were depending on the National Financial Aids Scheme (NSFAS). Staying at alone at a rental place and depending on the NSFAS is associated to engaging in risky sexual behaviours. Conclusions: Environmental factors and socio-economic factors contribute to risky sexual behaviours among students at a training college in Limpopo. Intervention to address the contributing factors should be implemented to curb the burden of engaging in risky sexual behaviours.
Exogenous Surfactant Versus Placebo in the Treatment of Moderate and Severe ARDS in COVID-19: The Pilot Study of a Clinical Trial
Authors: Ghahremani Mehdi , Fathi Mohammad , Massoudi Nilofar , Tavana Sasan , Fani Kamal , Nooraee Navid , Alamdari Nasser Malekpour , Besharat Sara , Abrandabadi Arash Najafi , Pirsalehi Ali , Khatiri Mohammad Ali Khabiri , Pouya Maryam Amini , Rajaei Samira , Dabbagh Ali 
Published: December 2020

Abstract
The authors have requested that this preprint be removed from Research Square.
Conditional Intravesical Recurrence-free Survival Rate after Radical Nephroureterectomy with Bladder Cuff Excision for Upper Urothelial Carcinoma
Authors: Chung Jae Hoon , Song Wan , Kang Minyong , Jeon Hwang Gyun , Jeong Byong Chang , Seo Seong IL , Jeon Seong Soo , Lee Hyun Moo , Sung Hyun Hwan 
Published: December 2020

Abstract
To evaluate the incidence and risk factors of (intravesical recurrence) IVR by analyzing a relatively large number of patients who underwent radical nephroureterectomy with bladder cuff excision (RNUx) for upper urothelial carcinoma (UTUC). Additionally, conditional IVR-free survival in patients with UTUC who had no history of bladder cancer and no concomitant bladder cancer was evaluated. We retrospectively analyzed the data of 1,095 patients with UTUC who underwent RNUx. The baseline characteristics, bladder tumor history, and UTUC characteristics were analyzed to evaluate oncological outcomes. To determine the factors affecting IVR, surgical modality, use of preoperative ureteroscopic examination (URS), TNM stage, and pathological outcomes were evaluated. Multivariable Cox regression analyses were performed to evaluate factors affecting IVR, and conditional IVR-free survival rate was analyzed using Kaplan–Meier curves. Among the 1,095 patients, 462 patients developed IVR and mean time of IVR was 13.08 ± 0.84 months after RNUx. A total of 30.74% of the IVR group and 15.32% of the without IVR group had a past history of bladder cancer (p < 0.001). In the multivariable analysis, a previous history of bladder cancer, multifocal tumors, the use of preoperative URS, the extravesical bladder cuffing method, lymph node involvement, positive surgical margins, and the use of adjuvant chemotherapy were determined to affect the IVR. The conditional IVRF rate at 12 months after RNUx was 74.0%, for those who IVRF for 12 months, the IVRF rate was 87.1% for the next 12 months (24 months after RNUx), and for the patients who IVRF for 24 months, the IVRF rate was 93.6% for the next 12 months (36 months after RNUx) and the IVRF rate was 97.3% for the next 12 months in IVRF of 60 months patients. The mean IVRF survival period of all patients was 136.84 months, 156.24 months in the patients with 6 months IVRF, 175.38 months for the patients with 12 months IVRF, 189.14 months for the patients with 36 months IVRF, and mean IVRF survival period was 178.21 months in 60 months IVRF patients. In 24 months IVRF patients after RNUx, only URS was evaluated to independently affect IVR (HR 1.945, p = 0.040). In patients with 36 months or more IVRF, there was no significant factor affecting IVR. Active IVR assessment is required until 36 months after RNUx. In addition, patient education and regular screening test such as urine analysis and cytology are required for patients who had IVRF for 36 months or longer.
Retrospective Non-target Analysis to Support Regulatory Water Monitoring: From Masses of Interest to Recommendations via in silico workflows
Authors: Lai Adelene , Singh Randolph R. , Kovalova Lubomira , Jaeggi Oliver , Kondic Todor , Schymanski Emma L. 
Published: December 2020

Abstract
BackgroundApplying non-target analysis (NTA) in regulatory environmental monitoring remains challenging - instead of having exploratory questions, regulators usually already have specific questions related to environmental protection aims. Additionally, data analysis can seem overwhelming because of the large data volumes and many steps required. This work aimed to identify environmental chemical unknowns via retrospective NTA within the scope of a pre-existing Swiss environmental monitoring campaign focusing on industrial chemicals. The research question addressed immediate regulatory priorities: identify pollutants with industrial point sources occurring at the highest intensities over two time points. Samples from 22 wastewater treatment plants obtained in 2018 and measured using liquid chromatography-high resolution mass spectrometry were retrospectively analysed by i) performing peak-picking to identify masses of interest, ii) prescreening and quality-controlling spectra, and iii) tentatively identifying priority “known unknown” pollutants by leveraging environmentally-relevant chemical information provided by Swiss, Swedish, EU-wide, and American regulators. This regulator-supplied information was incorporated into MetFrag, an in silico identification tool replete with “post-relaunch” features used here. This study’s unique regulatory context posed challenges in data quality and volume that were directly addressed with the prescreening, quality control, and identification workflow developed. ResultsOne confirmed and twenty-one tentative identifications were achieved, suggesting the presence of compounds as diverse as manufacturing reagents, adhesives, pesticides, and pharmaceuticals in the samples. More importantly, an in-depth interpretation of the results in the context of environmental regulation and actionable next steps are discussed. The prescreening and quality control workflow is openly accessible within the R package Shinyscreen, and adaptable to any (retrospective) analysis requiring automated quality control of mass spectra and non-target identification, with potential applications in environmental and metabolomics analyses. ConclusionsNTA in regulatory monitoring is critical for environmental protection, but bottlenecks in data analysis and results interpretation remain. The prescreening and quality control workflow, and interpretation work performed here are crucial steps towards scaling up NTA for environmental monitoring.
TaGST1 Gene and Its Regulatory Factor WRKY74 Mediate Copper Tolerance by Effecting Glutathione Accumulation in Wheat
Authors: Li Ge-Zi , Zheng Yong-Xing , Chen Shi-Juan , Liu Jin , Wang Peng-Fei , Wang Yong-Hua , Guo Tian-Cai , Kang Guo-Zhang 
Published: December 2020

Abstract
Background: Copper (Cu) is an important plant micronutrient; however, excessive Cu can disturb the protein structure, affect plant growth and development, and pose as a potential human health risk. Glutathione S-transferase (GST) is the key enzyme in glutathione (GSH) synthesis; it plays crucial role in Cu detoxification. Nonetheless, its regulatory mechanisms remain largely unclear.Results: A Cu-induced TaGST1 gene had been identified in this study. And the regulatory factor TaWRKY74 had been screen out by Yeast one-hybrid (Y1H) method. Their binding were checked by using another Y1H and luciferase (LUC) assays, indicated that TaWRKY74 bound to the TaGST1 promoter via W-box sequence. Moreover, TaWRKY74 or TaGST1 expression, GST activity, and GSH content were significantly inhibited in transiently TaWRKY74-silenced wheat plants under Cu stress. However, the contents of hydrogen peroxide (H2O2), malondialdehyde (MDA), and Cu were significantly increased. Further investigation found that transiently ectopic overexpression of TaWRKY74 increased GSH content, whereas decreased MDA content during Cu stress. Notably, exogenous application of GSH could reversed the adverse effects of transiently TaWRKY74-silenced wheat plants during Cu stress. Conclusions: These results indicated that TaWRKY74 regulated TaGST1 expression and affected GSH synthesis under Cu stress, and could be useful to ameliorate Cu toxicity for crop food safety.
Bracken Growth, Toxin Production and Transfer From Plant to Soil - A Two-year Monitoring Study
Authors: Garcia-Jorgensen Daniel B. , Diamantopoulos Efstathios , Kisielius Vaidotas , Rosenfjeld Mette , Rasmussen Lars H. , Strobel Bjarne W. , Hansen Hans Chr. B. 
Published: December 2020

Abstract
Background: Bracken fern (Pteridium aquilinum) is known to produce several toxic glycosides, of which ptaquiloside (PTA) is the most well documented. PTA may release from bracken to soil and leach to surface and groundwater. This study presents the first comprehensive long-term (2018-2019) monitoring study of bracken biomass, PTA content in the biomass, release by precipitation and soil solution concentrations at 50 cm depth. Moreover, lab experiments were carried to estimate the degradation of PTA, for different soil horizons and moisture contents. Results: The PTA content in bracken was highest at the beginning of the season, following a decreasing trend towards negligible values at the end of the season. The maximum seasonal PTA mass in the canopy was observed early in the summer, with values up to 1600 mg m-2. PTA is washed in high amounts by precipitation, with releases of up to 13.1 mg PTA m-2 during a single rain event. Concentrations of PTA in soil pore water were positively correlated with the mass of PTA in the canopy during the growing season. Peak concentrations of PTA in the soil solution were observed in July, with an average concentration of 1050 ng L-1.Conclusions: The production of PTA in bracken was found to be proportional to biomass production, while the mass of PTA being released is a function of volume and intensity of precipitation, as well as the bracken canopy development stage. Leaching of PTA takes place in the form of pulses linked to precipitation events, with soil pore water concentrations exceeding levels which are known to pose a risk to human health.
Association Between Dietary Phytochemical Index and Breast Cancer: a Case-control Study
Authors: Ghoreishy Seyed Mojtaba , Aminianfar Azadeh , Benisi-Kohansal Sanaz , Azadbakht Leila , Esmaillzadeh Ahmad 
Published: December 2020

Abstract
Background: Dietary intake of isoflavones has been positively associated with risk of breast cancer (BC) in some earlier studies. In addition, most studies on diet-disease associations came from western countries and limited data are available in the Middle-East. Methods: This case-control study was performed on 350 women with breast cancer aged over 30 years old who were recruited from hospitals or private clinics in Isfahan, Iran. All patients were diagnosed with BC during the maximum of the last 6 months using physical examination and mammography findings. Using cluster method sampling, 700 apparently healthy age- and socioeconomic status-matched controls were randomly selected from healthy women who had no relationship with BC patients and had no familial history of BC. Data on dietary intakes were collected using a validated food frequency questionnaire. The DPI was calculated based on dietary energy derived from foods rich in phytochemicals (kcal) divided by total daily energy intake (kcal) of each participant. Results: Mean ± SD age and BMI in the study participants were 62.4±10.8 y and 24.3±5.2 kg/m2, respectively. In the crude model, participants in the highest quartile of DPI had 63% lower odds of breast cancer compared to those in the lowest quartile (95% CI: 0.26, 0.54; P-trend <0.001). After adjustment for potential confounders, this inverse association became strengthened (95% CI: 0.22, 0.49; P-trend <0.001). Further adjustment for BMI did not change the association (OR for the highest quartile vs. the lowest quartile = 0.40, 95% CI: 0.26, 0.60; P-trend <0.001). Conclusion: In conclusion, a protective association was observed between DPI and BC in this case-control study. Therefore, high consumption of foods rich in phytochemicals such as fruits, vegetables and whole grains might help reducing the odds of BC among women.
Primary Hepatic Epithelioid Hemangioendothelioma: A Case Report and Literature Review
Authors: Wang Jing Rui , Lu Bei , Cai Yang 
Published: December 2020

Abstract
Background: Epithelioid hemangioendothelioma(EHE) is a low-grade malignant tumor of vascular origin. The rarity of HEHE make the diagnosis and treatment of this entity very challenging. Case presentation: We report a case of a 69-year-old female patient suffering from HEHE who complained of "Abdominal distension pain with dizziness, appetite loss more than half a month". Enhanced computed tomography (CT) of the upper abdomen indicated multiple space-occupying lesions in the liver. The pathological results of color ultrasound puncture suggested HEHE. We performe transcatheter arterial chemoembolization (TACE) and relevant examinations according to the patient's condition and the patient choice. Follow-up examinations 18 months after discharge did not demonstrate tumor recurrence.Conclusions:HEHE is a relatively rare hepatic malignant tumor derived from vascular endothelial cells, with low incidence, atypical clinical manifestations, difficult diagnosis, and the diagnosis can only be confirmed with pathological results. Currently, appropriate treatment methods should be selected according to the specific conditions of patients.