bluuebunny/crossref_metadata_2025_split huggingface dataset:
A“Duet‐Insurance” Sensing Strategy by Combining Janus TpMa COF/Eu‐doped α‐Fe2O3 and Variable‐Temperature Excitation for Robust, Visual Indoor Pollution Gas Detection
Authors: Bing Yu , Song Zhao , Jiang Hongtao , Xu Xiaoyi , Yu Zhongzheng , Zhou Tingting , Zhang Tong 
Published: December 2024

AbstractWater competitive adsorption and limited reaction sites on the micro‐scale sensing area of micro‐electro‐mechanical system (MEMS) sensors are two bottleneck problems that restrict the detection of trace indoor polluted gases, leading to drifting and weak signals. To address this, a “duet‐insurance” sensing strategy is proposed to protect and amplify the sensing signal. For the first‐level protection, the well‐designed double‐layer structure consisting of Janus TpMa covalent organic framework (COF)/Eu‐doped α‐Fe2O3 can resist diffusion of water molecules and facilitate the electron transfer from formaldehyde (CH2O) to sensing layers, benefiting from the outer hydrophobic character of Janus TpMa and the strong CH2O adsorption capacity of Eu‐doped Fe2O3. For the second‐level amplification, the unique variable temperature excitation facilitates the deep penetration of CH2O into the active sites across COF layers, enabling signal amplification through thermally actuated carrier modulation. The sensor demonstrates high sensing ability to the CH2O, with an ultra‐low limit of detection of 794 ppt. Leveraging the novel sensing strategy, a multi‐functional, visual sensing system is designed to identify multi‐indoor pollution gases by feature signal encoding and color mapping, showcasing the promising potential for MEMS sensors based on Janus TpMa COF/Eu‐doped α‐Fe2O3 materials.
Multilevel Stimulus‐Responsive Room Temperature Phosphorescence Achieved by Efficient Energy Transfer from Triplet Excitons to Mn2+ Pairs in 2D Hybrid Metal Halide
Authors: Peng Yuqi , Ma Junhao , Zhao Yuanlai , You Donghui , Yao Yuan , Deng Zhihao , Liao Jinfeng , Chang Yuanyuan , Shen Wei , Li Ming , He Rongxing , Zhou Lei 
Published: December 2024

AbstractSynthesis of color‐tunable ultralong room temperature phosphorescence (RTP) crystals with multilevel stimuli‐responsive properties is highly desirable due to their tremendous application prospects but has rarely been explored. Herein, a 2D organic–inorganic metal‐halide hybrid (ABA2CdCl4) has been originally designed and synthesized with efficient blue fluorescence and green RTP through Cd induced heavy atom effect. Due to the improved intermolecular interactions and enhanced light absorption, a high RTP efficiency up to 34% is achieved in ABA2CdCl4. With ABA2CdCl4 as a prototype, Mn2+‐doping strategy is successfully employed to construct multicomponent RTP material with wide‐tunable RTP property in response to multilevel external stimulus such as time, temperature and light. More importantly, Mn2+ pairs are formed in Mn2+‐doped ABA2CdCl4, which are observed in 2D metal‐halide hybrids for the first time. Due to the thermal assisted energy transfer from triplet excitons (organic unit) to Mn2+ pairs, and the thermally activated emission from Mn2+ pairs, tunable RTP colors between 270 and 333 K are easily realized, showing the highest sensitivity against temperature reported so far. By virtue of the above advantages, such materials are successfully applied in multilevel information storage and temperature sensors. The work promotes the development of multi‐stimuli responsive RTP systems based on hybrid metal halides.
Functionalized Nanozyme Microcapsules Targeting Deafness Prevention via Mitochondrial Homeostasis Remodeling
Authors: Ge Shengjie , Sun Aidong , Zhou Xinyu , Niu Ping , Chen Yong , Bao Xiaotao , Yu Meng , Zhong Zhenhua , Sun Jingwu , Li Guang 
Published: December 2024

AbstractMitochondrial dysfunction, which is the primary mechanism underlying cisplatin‐induced hearing loss, can potentially be mitigated by modulating the redox balance and reprogramming the energy metabolism to remodel mitochondrial homeostasis. Herein, N‐acetyl‐l‐cysteine–derived carbonized polymer dots (NAC CPDs) are embedded into manganese porphyrin–doped metal–organic frameworks and encapsulated using a polydopamine (PDA) coating and gelatin methacryloyl (GelMA) hydrogel to afford functionalized nanozyme microcapsules. Owing to their injectability and adhesion properties, these microcapsules exhibit the advantages of prolonged retention in the middle ear and sustained release in the inner ear. The synergy between the manganese porphyrin and polymer dots results in excellent antioxidant properties. The developed nanozymes activate the PI3K‐AKT pathway, reprogramming the energy supply mechanism, and inhibiting the oligomerization of BAX in mitochondria to prevent the leakage of mitochondrial DNA and cytochrome c. Therapeutic efficacy and related mechanisms are validated in vivo. Thus, this study on mitochondrial homeostasis remodeling by nanozyme microcapsules opens a new chapter in the treatment of hearing loss.
Rigidity‐Flexibility Regulation and Hard‐Soft Donor Combination: Dual Strategies in Covalent Organic Frameworks Construction for Actinides/lanthanides Separation
Authors: Cao Run‐Jian , Zhou Heng‐Yi , Wu Qun‐Yan , Xiao Zhe , Xiu Tao‐Yuan , Li Jie , Tang Hong‐Bin , Yuan Li‐Yong , Wu Wang‐Suo , Shi Wei‐Qun 
Published: December 2024

AbstractSeparating actinides from lanthanides is essential for managing nuclear waste and promoting sustainable nuclear energy development. The recycling of transuranium elements (TRUs: Np, Pu, Am) is also significant for various nuclear technology applications. In this study, a dual strategy is introduced to designing covalent organic frameworks (COFs) that skillfully combines molecular rigidity with flexibility, integrating both hard and soft donor atoms in the synthesis of monomers. This results in a specialized COF that efficiently and selectively captures TRUs from acidic aqueous solutions. By utilizing the topological arrangement of rigid ligands to influence the twisting and stretching of flexible ligands, coordination environment featuring nitrogen and oxygen is created, which enhances the separation of transuranium in various oxidation states over lanthanides. In 0.5 m HNO3 solution, the as‐synthesized DAPhen‐COF achieves removal rates of 99.1% for Np(V) and 95.8% for Pu(IV). For Am(III), the removal rate reaches 98.6% in 0.01 m HNO3. DAPhen‐COF exhibits remarkable selectivity for Np(V), with a separation factor of over 5000 for Np/Gd, outperforming other solid‐phase materials. This research provides a comprehensive investigation into the design and synthesis of COFs for actinide capture, marking the first application of COFs in the separation of various TRUs over lanthanides.
An Efficient Biosynthetic System for Developing Functional Silk Fibroin‐Based Biomaterials
Authors: Wang Feng , Lei Hexu , Tian Chi , Ji Yanting , Wang Fangyu , Deng Hanxin , Zhou Hongji , Chen Siyu , Zhou Yujuan , Meng Zihan , He Mengyao , Yang Shifeng , Dong Huan , Tu Ding , Wang He , Li Xian , Kaplan David L. , Xia Qingyou 
Published: December 2024

AbstractLong historical evolution and domestication endow silkworms with the super ability to synthesize and secrete massive silk proteins using silk glands. The major component of this secretion consists of silk fibroin, considered a promising biomaterial for tissue repairs and engineering. To further expand the utility of this unique protein, there is a continuing need for silk fibroin functionalization. Here, a highly‐efficient Fib‐HEXP biosynthetic system is established to synthesize massive recombinant RFP in silk fibers using transgenic silkworms, which accounts for ≈7.86% of silk mass and achieves fabrication of fluorescent silk fibroin (SF) biomaterials. The universality of the Fib‐HEXP system is validated by genetic engineering glucose oxidase (GOx) functionalized silk fibers for fabricating GOx‐SF hydrogels with antimicrobial activity to promote healing of infected diabetic wounds in mouse through the enzyme‐catalyzed reaction of glucose to gluconic acid and H2O2. These findings demonstrate that the Fib‐HEXP system provides an opportunity for genetic functionalization of SF to broaden the utility of this biomaterial for a range of potential applications.
Dual‐Channel Electrostatically Actuated MEMS Fabry–Perot Filtering Module for Near‐Infrared Spectroscopic Detection
Authors: Liu Siqi , Zhang Wei , Zhang Jiahang , Xu Liang , Yang Mingyu , Jiang Sijia , Ma Ding , Jiao Qingbin , Tan Xin 
Published: December 2024

AbstractMEMS‐based Fabry–Perot filter components (MEMS‐FPC) have garnered significant attention in the field of micro‐spectrometers due to their ability to perform high‐efficiency spectral analysis at the microscale. However, achieving optimal peak transmission performance across a broad spectral range remains a core challenge in the development of MEMS‐FPC modules. In this work, a novel dual‐channel is presented, electrostatically actuated NIR MEMS‐FPC filter module that overcomes the limitations of electrostatic tuning in spectral detection through the integration of an innovative tuning structure and dual‐channel filtering. Fabricated using wafer‐level bulk micromachining techniques, the module enables continuous tuning and precise detection under a driving voltage of 0–40 V. The two channels cover spectral ranges of 814–946 nm and 968–1211 nm, respectively, achieving peak transmittance over 79% with full‐width at half maximum (FWHM) values ranging from 7.59 to 43.29 nm, setting a new standard for performance in this spectral range. The results demonstrate the potential of MEMS‐FPC as a high‐performance spectral sensor, demonstrating its future application as a NIR microspectrometer when integrated with commercial CCDs. With its low power consumption and compact size, this module is well‐suited for integration into portable devices such as smartphones and drones, offering real‐time NIR spectral sensing capabilities.
Photoinduced Cu‐Catalyzed C2‐H Functionalization of Azoles using Aryl Thianthrenium Salts
Authors: Wang Zhenhui , Wang Jinfang , Yang Zhenning , Li Xinyao , Cheng Kaining , Liu Wei 
Published: December 2024

AbstractDevelopment of a mild approach for the highly efficient synthesis of 2‐aryl azoles, which are typically synthesized using high temperature, ligands and preactivated substrates, is highly desirable. Here, we report a mild and efficient photo‐induced Cu‐catalyzed C−H/C−H cross‐coupling to obtain C2‐functionalized azoles using aryl thianthrenium salt (Ar‐TTs). The reaction exhibits a broad substrate scope and an excellent functional group compatibility and serves as an ideal strategy for the late‐stage functionalization of pharmaceuticals. Additionally, this method enables the efficient synthesis of azole‐based polycyclic compounds.
Research on Fine‐Grained Phenotypic Analysis of Temporal Root Systems – Improved YoloV8seg Applied for Fine‐Grained Analysis of In Situ Root Temporal Phenotypes
Authors: Yu Qiushi , Zhang Meng , Wang Liuli , Liu Xingyun , Zhu Lingxiao , Liu Liantao , Wang Nan 
Published: December 2024

AbstractRoot systems are crucial organs for crops to absorb water and nutrients. Conducting phenotypic analysis on roots is of great importance. To date, methods for root system phenotypic analysis have predominantly focused on semantic segmentation, integrating phenotypic extraction software to achieve comprehensive root phenotype analysis. This study demonstrates the feasibility of instance segmentation tasks on in situ root system images. An improved YoloV8n‐seg network tailored for detecting elongated roots is proposed, which outperforms the original YoloV8seg in all network performance metrics. Additionally, the post‐processing method introduced reduces root identification errors, ensuring a one‐to‐one correspondence between each root system and its detection box. The experiment yields phenotypic parameters for fine‐grained roots, such as fine‐grained root length, diameter, and curvature. Compared to traditional parameters like total root length and average root diameter, these detailed phenotypic analyses enable more precise phenotyping and facilitate accurate artificial intervention during crop cultivation.
Regulation of Shade Avoidance Under Low‐Blue‐Light by MTA in Soybean
Authors: Zhang Liya , Liu Jun , Chen Jiaqi , Zhang Yanyan , Qin Chao , Lyu Xiangguang , Li Zhuang , Ji Ronghuan , Liu Bin , Li Hongyu , Zhao Tao 
Published: December 2024

AbstractUnder low blue light (LBL) conditions, soybean exhibits classic shade avoidance syndrome (SAS) with exaggerated stem elongation (ESE), leading to lodging and yield reduction in dense farming. Recently, mRNA modification by N6‐methyladenosine (m6A) has emerged as a crucial epigenetic mechanism regulating plant biological processes; however, its impact on shade avoidance remains unexplored. In this study, the double mutants, gmmtas, that are impaired in two m6A writer genes, GmMTAa and GmMTAb that encode m6A methyltransferases or m6A writers are generated. It is found that the gmmtas mutants showed a substantial reduction of m6A levels, a dwarf phenotype, and a diminished sensitivity to LBL. Further investigation of the gmmtas mutants demonstrates that GmMTA regulates shade avoidance response by altering the expression of GmCRY1s, GmSPAs, and GmCOP1s, resulting in increased accumulation of GmSTFs that are known to suppress the shad avoidance response in response to LBL in soybean. The findings reveal a novel molecular mechanism regulating shade resistance in soybean, providing insights into the epigenetic mechanisms of plant adaptation to changing light environments and paving the way for the development of shade‐tolerant soybean varieties.
Ubiquitination of CD47 Regulates Innate Anti‐Tumor Immune Response
Authors: Gou Qian , Yan Bingjun , Duan Yalan , Guo Yilei , Qian Jing , Shi Juanjuan , Hou Yongzhong 
Published: December 2024

AbstractIn addition to adaptive immune checkpoint of PD‐1/PD‐L1, the innate immune checkpoint SIRPα/CD47 plays an important role in regulation of tumor immune escape. However, the mechanism of CD47 ubiquitination on tumor immune escape remains unclear. Here it is found that TRAF2 bound to the C‐terminal of CD47 cytoplasmic fragment and induced its ubiquitination, leading to inhibition of CD47 autophagic degradation by disrupting its binding to LC3, which in turn inhibited macrophage phagocytosis and promoted tumor immune escape. In contrast, loss of TRAF2 facilitated CD47 autophagic degradation and inhibited tumor immune escape. Moreover, autophagy induction promoted CD47 degradation and enhanced the efficacy of CD47 antibody anti‐tumor immunotherapy. These findings revealed a novel mechanism of ubiquitination of CD47 on tumor immune escape.
A Review of End‐of‐Life Silicon Solar Photovoltaic Modules and the Potential for Electrochemical Recycling
Authors: Lee Jackson , Duffy Noel , Allen Jessica 
Published: December 2024

The mass deployment of solar energy technology has been inspired by sustainable energy objectives. However, end‐of‐life solar photovoltaic modules present the growing dilemma of solar waste management. A circular economy approach should therefore be applied to the solar industry due to the valuable materials contained within modules, and their upfront emissions and energy intensity. Solar module recycling has to date been delineated into three phases: disassembly, delamination, and extraction. Disassembly has been commercially established; delamination has experienced some progression with further development required to liberate the valuable solar cell material, while extraction has had more limited exploration, predominantly through a hydrometallurgical lens. Extraction via electrochemical methods, however, has received some recent attention in the literature with promising outcomes for both metal extraction and process electrification. Electrochemical approaches offer new methods for more advanced processing options. For example, high‐temperature molten salt electrorefining has been investigated for metallurgical‐grade silicon and could prove to be an effective process for recovering silicon. This review provides an overview of solar module recovery methods, with focus on novel and emerging electrochemical approaches including the applicability of electrorefining to upgrade recovered silicon from photovoltaic waste.
Blue‐LED Self‐Assembly‐Assisted Synthesis of New Photostable Organoboron Esters for Live‐Cell Imaging
Authors: Flores‐Amaro Mónica G. , García‐López María C. , Velázquez Hernández David A. , Reyes‐Pérez Horacio , Villarreal‐García Valeria , Jiménez‐Barrera Rosa Martha , Chan‐Navarro Rodrigo , González‐Villasana Vianey , Reséndez‐Pérez. Diana 
Published: December 2024

AbstractIn this work, we report a blue‐LED self‐assembly‐assisted synthesis of novel emissive organoboron esters, achieved in just 30 minutes with quantitative yields. The molecular structure in solution (characterized by 1H and 11B NMR, and mass spectrometry) was further confirmed via X‐ray molecular diffraction analysis for compound 3, where the boron ion adopts a distorted tetrahedral geometry. The photophysical properties of these molecules were analyzed in solution, revealing that 1, featuring tert‐butyl groups and boron heterocycles with a nitro‐substituent, exhibits superior photostability compared to its derivatives. Photobleaching values showed an inverse correlation with the oxidation potentials of compounds 1–3, except for 4, used as a reference. Mass spectrometry further revealed greater energetic stability of the molecular ion of 1. Notably, compound 3 demonstrated good solubility, high photostability, and adequate biocompatibility, making it a promising fluorescent dye for biomedical applications. Cytotoxicity assays in HEK‐293 cells across different concentrations confirmed its non‐toxic nature. Theoretical calculations further supported the high chemical stability of all compounds, attributing it to a synergistic interaction between electronic and steric effects, which protect the fluorophores by substitution of Schiff bases and formation of boron heterocycles. Additionally, 3 exhibited strong, non‐hazardous blue fluorescence when tested on HEK‐293 and MDA‐MB‐231 cells.
Polarity‐Reversed Functionalization of Aliphatic Aldehydes via Divergent Nickel Hydride Catalysis
Authors: Chen Changpeng , Xu Hanhong , Zhu Shaolin 
Published: December 2024

AbstractDivergent catalysis represents an exciting frontier for unlocking molecular structural diversity and exploring new activation modes. Here, we report the unexpected discovery of polarity‐reversed divergent activation and functionalization of aliphatic aldehydes, where enolizable aliphatic aldehydes are selectively activated by nickel hydride to form two distinct alkylnickel intermediates divergently. This mild and operationally simple process enables the transformation of a wide variety of readily available aliphatic aldehydes, along with alkyl or aryl electrophiles, into the corresponding secondary alcohols or more challenging deoxygenated alkanes with excellent chemoselectivity.
Ionic Liquid Assisted Synthesis of Metal Oxide Nanoparticles and Their Application for Photocatalytic Dye Degradation on Malachite Green
Authors: Rajarajeswari A. , Stella S. 
Published: December 2024

ABSTRACTOrganic dyes are extensively used in numerous sectors, for example, textiles, leather, food, pharmaceuticals, paint, and plastic. Industries have contributed directly to significant environmental contamination, particularly in the form of water pollution. The present work comprises a comparative study of the photocatalytic degradation of malachite green (MG) dye by using metal oxide nanoparticles (MONPs) such as copper oxide nanoparticles (CuO NPs), zinc oxide nanoparticles (ZnO NPs), and iron oxide nanoparticles (Fe3O4 NPs) coated with 1‐butyl‐3‐methylimidazolium hexafluorophosphate [BMIM][PF6] ionic liquid (IL) and bare MONPs. The above‐mentioned nanoparticles (NPs) were prepared by using the co‐precipitation method. The physico‐chemical characteristics of the bare MONPs and IL‐coated MONPs were characterized by X‐ray diffraction (XRD), Fourier transform spectroscopy (FTIR), UV–visible absorption spectroscopy (UV–Vis), photoluminescence (PL), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) with selected area electron diffraction (SAED). Average crystallite sizes of IL‐coated CuO NPs (13.9 nm), ZnO NPs (28.02 nm), and Fe3O4 NPs (4.16 nm) were found from an XRD study. The band gap values of [BMIM][PF6] coated CuO, ZnO, and Fe3O4 NPs were computed to be 1.85, 2.06, and 1.56 eV, respectively. The photocatalytic efficacy of synthesized NPs was examined on MG dye during a 60‐min period. The photocatalytic degradation of MG dye was more effective when using MONPs with an IL coating compared with MONPs without an IL coating.
Association of HLA‐G 3′‐UTR Haplotypes With Recurrent Spontaneous Abortion in Women From Northwest Iran
Authors: Moqadami Amin , Khalaj‐Kondori Mohammad , Haghi Mehdi 
Published: December 2024

ABSTRACTBackground and Objective(s)Human leukocyte antigen‐G (HLA‐G) is a critical protein in immune regulation and tolerance. Recurrent spontaneous abortion (RSA) is a complex disease influenced by genetic, immune dysfunction, and environmental factors. This study investigates the role of HLA‐G polymorphisms in the development of RSA.MethodsBlood samples were collected from 80 women with RSA and 200 women without a history of RSA. After DNA extraction, PCR was used to sequence the 3′‐UTR region. Allelic and genotypic frequencies were analyzed, and Haploview software was used for haplotype analysis.ResultsIndividual polymorphisms did not significantly differ between the two groups. However, haplotype analysis revealed significant differences. The UTR‐2 haplotype was more frequent in the RSA group compared to the healthy control group (p = 0.020), suggesting a potential association. Conversely, the UTR‐4 haplotype had a significantly lower frequency in the RSA group (p = 0.041), indicating a protective role against RSA.ConclusionsWhile individual polymorphisms did not differ significantly, haplotype analysis identified significant associations with RSA. These findings provide valuable insights into the genetic basis of the disease and may contribute to the development of new treatments and diagnostic tools.
Strategies to increase catalytic efficiency of manganese‐catalyzed aerobic oxidation of 5‐hydroxymethylfurfural
Authors: Yu Hyejin , Ryu Yeonkyeong , Kim Younghoon , Kim Hyun Sung , Cha Hyun Gil 
Published: December 2024

AbstractThe aerobic oxidation of 5‐hydroxymethylfurfural (HMF) into 2,5‐furandicarboxylic acid (FDCA), a bio‐based plastic monomer, is an important process for the valorization of biomass. Here, manganese oxides of various oxidation states with identical morphologies and similar surface areas were synthesized by introducing oxygen vacancy sites, and they were investigated as heterogeneous catalysts for HMF oxidation. Mn2O3 exhibited a remarkable catalytic efficiency due to synergistic effect of the oxidation state of metal moieties, the basicity of the catalyst, and oxygen mobility of the oxide materials under basic condition.