bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gender Identity and Phenotypic Variation of Sex Chromosome Disorders: A Study at Center for Disorder of Sex Development in Indonesia
Authors: Azalia Putri , Juniarto Achmad Zulfa , Winarni Tri Indah 
Published: December 2024

Background: Sex chromosome DSD (Disorder of Sex Development) can be caused by numerical or structural abnormality in sex chromosome, which will lead to the atypical development in phenotype and also psychosexual. Gender assignment often become the primary problem in management of individual with DSD.Objective: To describe gender identity and phenotype variability based on karyotype classification among sex chromosome DSD cases in Indonesia Methods: This study is a descriptive retrospective study. Analyzing gender identity, karyotype classification and phenotype data from medical record of patients with cytogenetic analysis results classified as sex chromosome DSD in CEBIOR over 18 years period from 2004 to 2022.Results: Data showed the sex chromosome DSD classification with karyotype 45,X and variant (without Y chromosome), constituted 43.7% (42/96) cases, 100 % (42/42) patients have female gender identity; 19.8% (19/96) cases had karyotype 45,X/46,XY or Turner variant mosaicism with Y chromosome, majority of patients have male gender identity 73.7% (14/19); 18.7% (18/96) cases had 47,XXY (Klinefelter syndrome) and variant, majority of patients have male gender identity in 88.9 % (16/18) cases; 11.4% (11/96) cases had 46,XX/46,XY karyotype, majority have male gender identity in 81.8 %(9/11) cases ; and 6 cases (6.25%) classified as others, 66.67% (4/6) cases all of which contain Y chromosome, have male gender identity.Conclusion: . This study shows the presence of Y chromosome in the karyotype support a male gender identity. Sex chromosome DSD constitute high karyotype diversity and wide phenotypic abnormalities that necessitates careful clinical and cytogenetic evaluation
Integrated rice farming systems for improved growth, yield and pest reduction
Authors: Ranjith R , Subrahmaniyan K , Elamathi S , Manimaran R , Manikandan K , Sivasankari Devi T 
Published: December 2024

Soil health and environmental degradation are some of the major challenges to the sustainable production of organic rice cultivation. The study utilized farming systems components like Azolla, fish and duck as nutrient sources in rice cultivation during late samba 2022-23 and 2023-24 at Tamil Nadu Rice Research Institute, Aduthurai, Tamil Nadu. The experiments were conducted with eleven treatments replicated thrice in a randomized block design, the treatments included green manure, fish, Azolla, duck and liquid bio fertilizers and their combinations with nano urea foliar spray were compared with RDF. The results demonstrated a significant positive impact of integrating farming system components on rice growth and productivity. GM- Rice + fish + Azolla + duck (PSB+KSB+ZSB) along with nano urea foliar spray (0.4 %) recorded the maximum growth and physiological parameters over other treatments. Similar results were also observed in yield attributes of rice viz., the number of panicles (457 m-2), panicle length (31.26 cm), panicle weight (3.94 g), and filled grains panicle-1 (331.5). The higher grain (6.06 t ha-1), straw yield (7.81 t ha-1), rice equivalent yield (REY) (22.55 t ha-1), system productivity (61.79 kg ha-1 day-1), sustainable yield index (0.881) and relative production efficiency (440.3 %) of rice were recorded in GM- Rice + fish + Azolla + duck (PSB+KSB+ZSB) along with nano urea foliar spray (0.4 %). Additionally, lower pest incidences and higher insect pest control efficiency, richness, diversity and evenness indices were observed in green manure, Azolla, fish and duck-adopted treatments. The findings of experiments revealed that the inclusion of integrated farming system components significantly improved the yield and reduced pest incidences in rice.
Theology and Philology in Biblical Translation according to Franciscus Titelmans (1502–1537) on the Example of the Book of Job
Authors: Mantyk Tomasz Karol 
Published: December 2024

Abstract
Franciscus Titelmans (1502–1537) is known to scholars of biblical humanism as a critic of Erasmus’ Novum Instrumentum. His own biblical works have been, however, little studied. This article discusses his approach to humanist methodology on the example of his commentary to the Book of Job. It demonstrates that he used original languages of the Bible to correct copyists’ mistakes and elucidate the meaning of ambiguous passages. Nevertheless, the application of philological tools had strict limits for him: the Church’s dogma. The Vulgate could be corrected where no doctrinal issue was at stake, but whenever an important proof text of the Vulgate differed from the Hebrew and Greek versions, the ancient Latin translation was to be preferred. Titelmans went as far as to claim that it was the Vulgate, which expressed fully the true meaning of the Word of God, the meaning that the Hebrew and Greek texts contained in a hidden from.
William Perkins’s (1558–1602) Case Divinity as a School of Christian Prudence
Authors: Revell Roger L. 
Published: December 2024

Abstract
This article engages with the moral theology of William Perkins of Cambridge (1558–1602), with particular attention to his celebrated and influential case divinity. Perkins’s case divinity set the stage for a Protestant return to casuistical ethics, following the eschewal and neglect of such applied moral reflection in the initial phases of the Reformation. While his cases originally received a positive reception, more modern evaluations have been less approving. Perkins has been accused of attempting to curtail Christian liberty by forging codes of piety and morality that crowd out space for personal deliberation and judgment. This essay argues that such evaluations misapprehend Perkins’s casuistical enterprise, overlooking or obscuring its chief and ultimate aim, which is didactic rather than prescriptive.
Religious Coexistence in the Dutch Republic and France in the Seventeenth Century: Legal Systems, Sacred Spaces, and Minority Resilience in Utrecht and Nîmes
Authors: Kang Sukhwan , Yasuhira Genji 
Published: December 2024

Abstract
This article examines religious coexistence and survival tactics of the religious minority groups in the Dutch Republic and the Kingdom of France, comparing Utrecht’s Catholics and Nîmois Huguenots in three respects: legal systems, battles over sacred spaces, and minority resilience. The distinct legal systems in the two countries – the Union of Utrecht and the Edict of Nantes – shaped two different forms of religious diversity in Utrecht and Nîmes, that is, de facto and de jure coexistence. Under these divergent legal settings, both Catholics and Protestants in the two cities similarly asserted their presence in the urban space and sought to practice their faith publicly. However, the minorities’ tactics in the conflicts over sacred spaces and the extent of physical violence in those battles differed significantly. While facing challenging circumstances in the last quarter of the seventeenth century, both minority groups demonstrated a remarkable resilience, mobilizing various survival tactics. They constantly negotiated the detailed conditions of coexistence with the dominant faith, attempting to carve out their own positions within their local, precarious environment.
Divine Warrant and Political Discipline: Preaching on the Groningen Landdag in the Third Quarter of the Seventeenth Century in the City of Groningen
Authors: Basoski Theo 
Published: December 2024

Abstract
At the end of the sixteenth century in the (nascent) Dutch Republic, a new balance between government and Church was set as the Reformed Church became the public church. In the public church, the government had the authority to announce special days of prayer without permission from the ecclesiastical authorities. Furthermore, ministers were expected to give religious justification for the government’s policy. This article presents a case study of special days of prayer in the city of Groningen. Every year a special church service was held in Groningen on the so-called Groninger Landdag, the day on which the States distributed the official positions. This paper discusses two sermons delivered by Groningen ministers on such a Groninger Landdag. The first is the 1650 sermon from Johannes Martinus, the second the 1666 sermon from Thomas Alberthoma. I will argue that these sermons show how the ministers operated as civil servants and followed the government, and at the same time operated as servants of the Word of God and therefore could be critical towards the authorities. The regents needed divine warrant for their position.
“Enervare atque pervertere verba illa Christi Matthaei 11”: Arguing over Matthew 11:21–22 in Luis de Molina’s (1535–1600) Concordia and Leonardus Lessius’ De gratia efficaci
Authors: de Bruijn Niels 
Published: December 2024

Abstract
In the second half of the sixteenth century, the Jesuits Luis de Molina (1535–1600) and Leonardus Lessius (1554–1623) had been forced to defend their views on grace, free will and predestination against multiple attacks by fellow Catholic theologians. By comparing Molina’s commentaries on Matt 11:21–22 in his Concordia of 1595 with Lessius’ remarks on the same verses in his De gratia efficaci (1610), this contribution seeks to provide insights into the extent to which the theological views of both Jesuits differed. The article concludes that Lessius’ theological view diverges from Molina’s where it concerns the physical workings of grace. Furthermore, the two Jesuits differ on the question whether God grants equal aid to all or bestows some with more aid than others. Molina held the latter view, while Lessius, in keeping with the ideas of Henry of Ghent, defended the former.
Мифологический подтекст «мессианской» деятельности героя в трилогии «На ростанях» Я. Коласа
Authors: Михайловна Иоскевич Марина 
Published: December 2024

В статье раскрывается мифологическая последовательность функций главного героя в трилогии «На ростанях» Я. Коласа, которая признается одним из значимых белорусских произведений революционной тематики. Полная реализация представленной функциональной последовательности формирует мифологический подтекст «мессианской» деятельности героя, усиленный библейскими аллюзиями и реминисценциями на эксплицитном уровне художественного текста, что способствует внедрению социального мифа о необходимости революционных преобразований в читательское сознание.
PATRIMÔNIO HISTÓRICO - EDUCATIVO
Authors: Mendes Paulino Peterson , Antunes Silva Dilma , Santiago do Nascimento Ana Paula 
Published: December 2024

Este artigo resulta de um Projeto de Extensão que teve como mote a celebração dos 50 anos do Núcleo de Educação Infantil–Escola Paulistinha de Educação, da Universidade Federal de São Paulo, em que propuséramos uma discussão sobre o processo de (re)construção histórica do patrimônio educativo dessa instituição. Para tanto, apresentamos um conjunto de materiais portadores de memória que, ao serem ana
lisados crítica e reflexivamente, oferecem indícios sobre o funcionamento da escola, suas principais mudanças e permanências, sobre quem eram e como se relacionam seus sujeitos, e ratificam a importância da guarda e preservação da memória de instituições e escolares.
Las narrativas del arte en Colombia. Construcción y uso de un concepto historiográfico, 1850-1930
Authors: Cruz Juan Pablo 
Published: December 2024

Objetivo: evaluar, en términos de discurso, las reflexiones desarrolladas por José Manuel Groot, Alberto Urdaneta y Roberto Pizano en torno a la producción visual colonial, con el fin de rastrear los orígenes del concepto de arte aplicado a la producción visual del periodo colonial y utilizado hoy como parte de la reflexión historiográfica. Metodología: Lo anterior se realiza siguiendo los planteamientos hechos por la llamada historia conceptual, a partir de la cual se asume que la idea de arte asociada a la producción visual colonial se presenta como un constructo propio del siglo XIX, cuyo resultado fue la subversión del lugar de producción de la pintura de los siglos XVI y XVII. Originalidad: Este estudio se distancia de quienes aún hoy asumen la producción visual de los siglos XVI y XVII como producto artístico, legible a la luz del aparataje institucionalizado por el academicismo y las reflexiones estéticas vinculadas a la filosofía y la historia del arte propias de los siglos XVIII y XIX. En esta medida, introduce una reflexión útil en relación con la lectura y la correcta comprensión, no solo del llamado “arte colonial”, sino también de los procesos de construcción y resignificación del pasado llevados a cabo en el siglo xix en Colombia. Conclusiones: la producción visual colonial, concebida originalmente como fabricación mecánica, terminó convertida, gracias a la mirada de hombres como Groot, Urdaneta y Pizano, en un producto estético, un arte que, bajo la mirada del siglo XIX, representaba parte de la civilización heredada del mundo hispánico que debía hacer parte del ser cultural de la nación. Bajo este supuesto, se plantea la necesidad de reevaluar los métodos utilizados por la historia del arte para observar los objetos del pasado, acercando sus metodologías a las de la historia conceptual o el constructivismo histórico empleadas en la historiografía tradicional desde la década de 1970.
Parcere subiectis et debellare superbos...
Authors: De Decker Klara , Piccioni Aura 
Published: December 2024

AbstractThe paper deals in with the evidence probably related to a bronze workshop discovered along the Pannonian limes, at Dunaújváros (Hungary), an ancient Roman auxiliary fort with an associated civil settlement known as Intercisa. Such evidence raises the issue if the workshop was under the military command inside or outside the fort.Rescue excavations were carried out in 1962 and 1967. In the 1970s, a late Roman building was discovered with 19 furnaces filled with glass, bronze and iron slag under it. Metal slag and half-melted bronze fragments were found in furnaces No. 7 and No. 10. The existence and density per square meter of such objects led to the interpretation of the site as a workshop district. The coin finds and the terra sigillata fragments allow the life of this district to be dated to the 2nd–3rd century AD.Some years later other excavations were carried out on an area of 800 m2 about a 200 m distance from the workshop district. Among other finds a pit (1983/9) was brought to light in the area containing huge amounts of terra sigillata and pottery, as well as other objects, among them a bronze statuette of Mars Ultor also thrown in for waste disposal. This find comes as no surprise in military forts, but this iconography remains unique in Intercisa, while fragments probably belonging to bronze imperial statues come from the camp (Visy, 1983). Thanks to comparisons with other statuettes of the same kind the changing interpretation of such iconography in the provinces is discussed and its importance for the military fort analyzed as well.
Impact of centrifugal-flow left ventricular assist device implantation on the disease course, functional class, and quality of life in patients with end-stage heart failure with reduced ejection fraction. A 6-month follow-up experience
Authors: Shakhramanova Zh. A. , Narusov O Yu. , Amanatova V. A. , Osmolovskaya Yu. F. , Ganaev K. G. , Shiryaev A. A. , Akchurin R. S. , Merkulova I. A. , Pevsner D. V. , Saidova M. A. , Tereschenko S. N. 
Published: December 2024

Aim. To study mortality, postoperative complications, clinical course, and quality of life of patients with heart failure (HF) within 6 months after left ventricular assist device (LVAD) implantation.Material and methods. The study included 53 patients who met the criteria for LVAD implantation. Twenty three patients underwent surgery (group 1), while 30 patients refused implantation (group 2). The follow-up period was 6 months. The death number and causes, hospitalization and HF decompensation rates, the changes of N-terminal pro-brain natriuretic peptide levels, the functional class of HF, the incidence of postoperative complications were assessed. Exercise tolerance (ET) was determined using a 6-minute walk test, while quality of life — using the EQ-5D questionnaire.Results. Patient mortality in the LVAD group was 26%, while in group 2 — 23,3%. In the main group, 1 patient died due to cardiovascular cause; 2 — gastrointestinal bleeding; 1 — infectious complications (sepsis); 1 — cerebrovascular accident; 1 — acute non-occlusive mesenteric ischemia. In the control group, all death cases were due to cardiovascular pathology. Among the complications after implantation, the most common were pleurisy, delirium, ventricular tachycardia, right ventricular failure, gastrointestinal bleeding, LVAD-associated infection. In group 1, there was a significantly lower number of rehospitalizations compared to group 2, including those due to HF decompensation (p=0,034, p<0,001, respectively). In the main group, there was an improvement in the quality of life (p<0,001), HF class (p<0,001), and ET (p=0,006), which led to a reliable difference between the groups after 6 months.Conclusion. LVAD implantation is accompanied by a decrease in the number of rehospitalizations and HF decompensation, as well as improvement of ET, HF class and quality of life of patients, but not a decrease in mortality. To reduce the incidence of postoperative complications and improve the prognosis, a more careful selection of patients for intervention, assessment of their cognitive status and compliance is necessary.
Analysis of the relationship between the serum lipopolysaccharide level and other inflammation markers, clinical and functional characteristics of patients with COPD without exacerbation
Authors: Smirnova M. I. , Antipushina D. N. , Kurekhyan A. S. , Gumanova N. G. , Koshelyaevskaya Ya. N. , Metelskaya V. A. , Bogdanova N. L. , Pokrovskaya M. S. , Litinskaya O. A. , Kontsevaya A. V. , Drapkina O. M. , Makarov V. V. , Yudin S. M. 
Published: December 2024

Lipopolysaccharide (LPS) from gram-negative bacteria is considered a pathogenetic factor of many diseases. It is also known to include exacerbations of chronic obstructive pulmonary disease (COPD), but this effect has been little studied in stable COPD.The aim of the study was to evaluate the relationship between serum LPS levels and inflammatory markers, clinical and functional characteristics of COPD without exacerbation.Methods. The pilot study included 29 patients with COPD who did not have any exacerbations requiring antibacterial therapy or systemic steroids for 3 or more months and 27 patients without respiratory diseases, matched by age and gender (63.9 ± 6.3 years, 69% men). All patient data were taken from the database of National Medical Research Center for Therapy and Preventive Medicine. The differences were considered statistically significant at p < 0.05; and a trend (change of variables in one direction requiring further investigation) at p ≥ 0.05 – 0.075.Results. The COPD group showed a tendency towards a lower LPS level (p = 0.062). The levels of TMAO and CRP were significantly lower in the control group (p < 0.05), and the fibrinogen and leukocyte levels did not differ. In the COPD group, a direct correlation was found between the LPS level and quality of life according to the CAT (COPD Assessment Test™) (r = 0.43; p = 0.019), an inverse correlation with the spirometry parameters (p < 0.05), and a trend towards an association between LPS and age (r = –0.34; p = 0.075), body mass index (r = 0.34; p = 0.072), waist circumference (r = 0.35; p = 0.064), and smoking status (r = 0.35; p = 0.061). No such relationships were seen in the control group. No relationship with exacerbations of COPD was found during the prospective follow-up (12 months).Conclusion. The level of LPS tends to differ between patients with stable COPD and patients without COPD, and correlates with severity of symptoms and lung function impairment in COPD patients. Further larger studies in this area are advisable.
Clinical features of chronic obstructive pulmonary disease in patients with pulmonary tuberculosis and HIV infection
Authors: Tlais H. , Anaev E. Kh. , Kniajeskaia N. P. , Shchelykalina S. P. , Belevskiy A. S. 
Published: December 2024

Aim. To conduct a comparative assessment of clinical, functional and laboratory parameters in patients with COPD and pulmonary tuberculosis with and without HIV infection.Methods. 160 patients with COPD and pulmonary tuberculosis were examined, including 80 with HIV infection and 80 without HIV infection. The patients were hospitalized in the State Budgetary Healthcare Institution “City Anti-Tuberculosis Dispensary” (Saint Petersburg). The clinical symptoms (shortness of breath according to the mMRC, CAT), laboratory parameters, the viral load (the number of virus copies and CD4 cells in 1 ml of blood and as a percentage of lymphocytes) and the lung function were assessed.Results. All examined patients had severe COPD with 2 or more exacerbations per year. More than 90% of the patients were current or former smokers. The HIV-positive patients with COPD and tuberculosis were younger than the HIV-negative (the mean age was 44 (41; 48) years versus 53 (45; 63) years, p < 0.001). The body mass index in the HIV-negative patients was higher than in the HIV-positive (22.15 (19.85; 25.13) kg/m2 vs 21.2 (19.3; 22.95) kg/m2, p = 0.050). The HIV-positive patients with low viral load (40 copies/ml and below) statistically significantly differed from the HIV-positive patients with high viral load (above 40 copies/ml) in the CD4 cell count (p < 0.001). Both the “younger” (aged 50 years or less) and “older” (aged over 50 years) HIV-positive patients with COPD and tuberculosis had more severe dyspnea compared to the HIV-negative patients (p < 0.001). COPD symptoms according to the CAT test were more severe in both “younger” and “older” HIV-positive patients (p < 0.001), and the score was higher in the HIV-positive patients compared to the HIV-negative patients (p < 0.05). The severity of COPD according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria was significantly higher in both “younger” and “older” HIV-positive patients compared to the HIVnegative patients (p < 0.05).Conclusion. Patients with COPD, tuberculosis, and HIV infection have decreased body weight, more pronounced dyspnea and symptoms of COPD and obstructive pulmonary ventilation disorders compared to the patients without HIV infection.