bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding the impacts of NPM and proposed solutions to the healthcare system reforms in Indonesia: the case of BPJS
Authors: Erniaty Erniaty , Harun Harun 
Published: November 2019

Abstract
This study critically evaluates the adoption of a universal healthcare system recently introduced by the Indonesian government in 2014. Our study is driven by the lack of critical analysis of social and political factors and unintended consequences of New Public Management, which is evident in the healthcare sector reforms in emerging economies. This study not only examines the impact of economic and political forces surrounding the introduction of a universal health insurance programme in the country but also offers insights into the critical challenges and undesirable outcomes of a fundamental reform of the healthcare sector in Indonesia. Through a systematic and detailed review of prior studies, legal sources and reports from government and media organizations about the implementation and progress of an UHC health insurance programme in Indonesia, the authors find that a more democratic political system that emerged in 1998 created the opportunity for politicians and international financial aid agencies to introduce a universal social security administration agency called Badan Penyelenggara Jaminan Sosial (BPJS). Despite the introduction of BPJS to expand the health services’ coverage, this effort faces critical challenges and unintended outcomes including: (1) increased financial deficits, (2) resistance from medical professionals and (3) politicians’ tendency to blame BPJS’s management for failing to pay healthcare services costs. We argue that the adoption of the insurance system was primarily motivated by politicians’ own interests and those of international agencies at the expense of a sustainable national healthcare system. This study contributes to the healthcare industry policy literature by showing that a poorly designed UHC system could and will undermine the core values of healthcare services. It will also threaten the sustainability of the medical profession in Indonesia. The authors offer several suggestions for devising better policies in this sector in the developing nations.
Glycogen storage disease type 1a is associated with disturbed vitamin A metabolism and elevated serum retinol levels
Authors: Saeed Ali , Hoogerland Joanne A , Wessel Hanna , Heegsma Janette , Derks Terry G J , van der Veer Eveline , Mithieux Gilles , Rajas Fabienne , Oosterveer Maaike H , Faber Klaas Nico 
Published: November 2019

AbstractGlycogen storage disease type 1a (GSD Ia) is an inborn error of metabolism caused by mutations in the G6PC gene, encoding the catalytic subunit of glucose-6-phosphatase. Early symptoms include severe fasting intolerance, failure to thrive and hepatomegaly, biochemically associated with nonketotic hypoglycemia, fasting hyperlactidemia, hyperuricemia and hyperlipidemia. Dietary management is the cornerstone of treatment aiming at maintaining euglycemia, prevention of secondary metabolic perturbations and long-term complications, including liver (hepatocellular adenomas and carcinomas), kidney and bone disease (hypovitaminosis D and osteoporosis). As impaired vitamin A homeostasis also associates with similar symptoms and is coordinated by the liver, we here analysed whether vitamin A metabolism is affected in GSD Ia patients and liver-specific G6pc−/− knock-out mice. Serum levels of retinol and retinol binding protein 4 (RBP4) were significantly increased in both GSD Ia patients and L-G6pc−/− mice. In contrast, hepatic retinol levels were significantly reduced in L-G6pc−/− mice, while hepatic retinyl palmitate (vitamin A storage form) and RBP4 levels were not altered. Transcript and protein analyses indicate an enhanced production of retinol and reduced conversion the retinoic acids (unchanged LRAT, Pnpla2/ATGL and Pnpla3 up, Cyp26a1 down) in L-G6pc−/− mice. Aberrant expression of genes involved in vitamin A metabolism was associated with reduced basal messenger RNA levels of markers of inflammation (Cd68, Tnfα, Nos2, Il-6) and fibrosis (Col1a1, Acta2, Tgfβ, Timp1) in livers of L-G6pc−/− mice. In conclusion, GSD Ia is associated with elevated serum retinol and RBP4 levels, which may contribute to disease symptoms, including osteoporosis and hepatic steatosis.
Revisiting the competency trap
Authors: Denrell Jerker , Le Mens Gaël 
Published: November 2019

Abstract
We revisit the competency trap and reexamine when it occurs. We show that a bias against alternatives that improve with practice does not require that learning is myopic in the sense of lacking foresight or failing to explore. The same bias occurs even if learners engage in substantial exploration and have foresight. In fact, we demonstrate that even a rational and foresighted learner, who follow an optimal strategy for balancing exploration and exploitation, will learn to prefer alternatives with initially high payoffs that decrease with practice over alternatives, with identical expected values, that have initially low payoffs that increase with practice. Our results show that a bias against alternatives that improve with practice is due to an asymmetry in error correction rather than to myopic learning. The implication is that a wide range of selection systems, even optimally designed ones, will be biased against late-bloomers.
Otolith increment width-based chronologies disclose temperature and density-dependent effects on demersal fish growth
Authors: Vieira Ana Rita , Dores Sandra , Azevedo Manuela , Tanner Susanne E 
Published: November 2019

Abstract
Climate change and fishing are drastically impacting marine ecosystems. Comprehending the biological consequences of these effects on commercially exploited fish is especially challenging. Here, we developed a 43-year otolith increment width-based growth chronology for one of the most important commercially exploited fish species in the Northeast Atlantic (European hake, Merluccius merluccius). Increasingly complex linear mixed-effects models were used to partition growth variation into intrinsic (age, sex, and age-at-capture) and extrinsic (environmental and biotic variables) factors, allowing age interaction with extrinsic variables to assess age-dependent responses in growth. Our results provided strong evidence that European hake growth is impacted by ocean temperature, namely sea surface temperature and temperature at depth, and species abundance (recruitment), with different responses depending on fish age. We found evidence that increasing ocean temperature could be highly detrimental for species growth especially during the first years of life. We provided insights into the effects of environmental and biotic factors on species growth variation. Such information is key to recognize the sensitivity of European hake growth to climate change, which may contribute to sustainable management policies for this valuable resource.
Analysis of Time-Course, Dose-Effect, and Influencing Factors of Antidepressants in the Treatment of Acute Adult Patients With Major Depression
Authors: Cheng Qingqing , Huang Jihan , Xu Ling , Li Yunfei , Li Huafang , Shen Yifeng , Zheng Qingshan , Li Lujin 
Published: November 2019

AbstractObjectiveModel-based meta-analysis was used to describe the time-course and dose-effect relationships of antidepressants and also simultaneously investigate the impact of various factors on drug efficacy.MethodsThis study is a reanalysis of a published network meta-analysis. Only placebo-controlled trials were included in this study. The change rate in depression rating scale scores from baseline was used as an efficacy indicator because a continuous variable is more likely to reflect subtle differences in efficacy between drugs.ResultsA total 230 studies containing 64 346 patients were included in the analysis. The results showed that the number of study sites (single or multi-center) and the type of setting (inpatient or noninpatient) are important factors affecting the efficacy of antidepressants. After deducting the placebo effect, the maximum pure drug efficacy value of inpatients was 18.4% higher than that of noninpatients, and maximum pure drug efficacy value of single-center trials was 10.2% higher than that of multi-central trials. Amitriptyline showed the highest drug efficacy. The remaining 18 antidepressants were comparable or had little difference. Within the approved dose range, no significant dose-response relationship was observed. However, the time-course relationship is obvious for all antidepressants. In terms of safety, with the exception of amitriptyline, the dropout rate due to adverse events of other drugs was not more than 10% higher than that of the placebo group.ConclusionThe number of study sites and the type of setting are significant impact factors for the efficacy of antidepressants. Except for amitriptyline, the other 18 antidepressants have little difference in efficacy and safety.
Dispersal From Overwintering Sites, Action Thresholds for Blueberry Maggot Fly (Diptera: Tephritidae), and Factors That Can Influence Variation in Predicted Fruit Infestation Levels in Maine Wild Blueberry: Part I
Authors: Drummond Francis A , Collins Judith A 
Published: November 2019

Abstract
Between 1996 and 2003 field studies were conducted in wild blueberry, Vaccinium angustifolium Aiton (Ericales: Ericaceae) to determine action thresholds for the blueberry maggot fly, Rhagoletis mendax Curran (Diptera: Tephritidae). Thresholds were based upon cumulative fly trap captures on baited Pherocon AM traps. The cumulative numbers of R. mendax flies captured over time was a significant predictor of infested fruit levels (maggots/liter blueberries). Fifty percent of the variance in fruit infestation is explained by fly captures. Based upon this relationship, the University of Maine Cooperative Extension has recommended action threshold of 10 cumulative fly captures/trap. However, this threshold is liberal in terms of risk as only 50% of the variance in fruit infestation is explained by fly captures. The dynamics of colonization rate and fly physiological status entering fruit-bearing fields might partially explain the variance in the action threshold. The majority of flies emerge from pruned fields or along forest scrub/shrub field edges, and it takes between 1 and 10 d (mean = 4.1 ± 0.9 d) for the populations to enter adjacent fruit-bearing fields. Flies dispersed from pruned fields at a decreasing rate the farther they dispersed. The rate of dispersal into fruit-bearing wild blueberry fields also depends upon the overwintering site quality. Sites with fruit exhibited both delayed colonization and lower colonization rates into fruit-bearing fields than adjacent pruned fields with no fruit. We also found that as the season progressed the proportion of flies capable of laying eggs varied greatly by location and year.
Pushing for Political and Legal Change: Protecting the Cultural Identity of Travellers in the Netherlands
Authors: Huijbers Leonie M , Loven Claire M S 
Published: November 2019

Abstract
On 12 July 2018, the central government of the Netherlands changed its approach relating to traveller camps in the Netherlands. This change constitutes a huge political shift, as the government had previously adopted a ‘hands-off’ and ‘repressive-inclusion’ strategy, which was especially known for its infamous ‘phase-out policy’ or ‘extinction policy’ of traveller camps. This has now been replaced by a fundamental rights-proof approach that facilitates the travellers’ way of life. This article aims to uncover the various actions undertaken by international and national actors that seem to have contributed to the Dutch government’s changed stance. It looks particularly at the role played by four national actors: the Netherlands Institute for Human Rights, the National Ombudsman, the Public Interest Litigation Project, and activist Roma, Sinti and travellers and their various interest groups. The article concludes that these actors’ efforts to establish political and legal change were successful as they addressed the same issue from different vantage points and through different means. That is, they all focused on the issue of the incompatibility of the phase-out policy with fundamental rights standards and relied on a variety of means available to them (such as litigation, lobbying, reporting, raising international awareness, and ensuring media coverage). By drawing some general lessons from this case study, this article aims to contribute to the existing literature on mobilizing human rights. In particular, it focuses on the (legal) activities national actors can undertake to bring about political and legal change in order to enforce the compliance of national authorities with fundamental rights standards in both law and policy.
Robo-Advising: Learning Investors’ Risk Preferences via Portfolio Choices*
Authors: Alsabah Humoud , Capponi Agostino , Ruiz Lacedelli Octavio , Stern Matt 
Published: November 2019

Abstract
We introduce a reinforcement learning framework for retail robo-advising. The robo-advisor does not know the investor’s risk preference but learns it over time by observing her portfolio choices in different market environments. We develop an exploration–exploitation algorithm that trades off costly solicitations of portfolio choices by the investor with autonomous trading decisions based on stale estimates of investor’s risk aversion. We show that the approximate value function constructed by the algorithm converges to the value function of an omniscient robo-advisor over a number of periods that is polynomial in the state and action space. By correcting for the investor’s mistakes, the robo-advisor may outperform a stand-alone investor, regardless of the investor’s opportunity cost for making portfolio decisions.
Recursive enumerability and elementary frame definability in predicate modal logic
Authors: Rybakov Mikhail , Shkatov Dmitry 
Published: November 2019

AbstractWe investigate the relationship between recursive enumerability and elementary frame definability in first-order predicate modal logic. On one hand, it is well known that every first-order predicate modal logic complete with respect to an elementary class of Kripke frames, i.e. a class of frames definable by a classical first-order formula, is recursively enumerable. On the other, numerous examples are known of predicate modal logics, based on ‘natural’ propositional modal logics with essentially second-order Kripke semantics, that are either not recursively enumerable or Kripke incomplete. This raises the question of whether every Kripke complete, recursively enumerable predicate modal logic can be characterized by an elementary class of Kripke frames. We answer this question in the negative, by constructing a normal predicate modal logic which is Kripke complete, recursively enumerable, but not complete with respect to an elementary class of frames. We also present an example of a normal predicate modal logic that is recursively enumerable, Kripke complete, and not complete with respect to an elementary class of rooted frames, but is complete with respect to an elementary class of frames that are not rooted.
Standpoint semantics for polysemy in spatial prepositions
Authors: Rodrigues Edilson J , Santos Paulo E , Lopes Marcos , Bennett Brandon , Oppenheimer Paul E 
Published: November 2019

AbstractIn this paper, we present a formalism for handling polysemy in spatial expressions based on supervaluation semantics called standpoint semantics for polysemy (SSP). The goal of this formalism is, given a prepositional phrase, to define its possible spatial interpretations. For this, we propose to characterize spatial prepositions by means of a triplet $\langle $image schema, semantic feature, spatial axis$\rangle $. The core of SSP is predicate grounding theories, which are formulas of a first-order language that define a spatial preposition through the semantic features of its trajector and landmark. Precisifications are also established, which are a set of formulae of a qualitative spatial reasoning formalism that aims to provide the spatial characterization of the trajector with respect to the landmark. In addition to the theoretical model, we also present results of a computational implementation of SSP for the preposition ‘in’.
Identical or fraternal twins? The chemical homogeneity of wide binaries from Gaia DR2
Authors: Hawkins Keith , Lucey Madeline , Ting Yuan-Sen , Ji Alexander , Katzberg Dustin , Thompson Megan , El-Badry Kareem , Teske Johanna , Nelson Tyler , Carrillo Andreia 
Published: November 2019

ABSTRACT
One of the high-level goals of Galactic archaeology is chemical tagging of stars across the Milky Way to piece together its assembly history. For this to work, stars born together must be uniquely chemically homogeneous. Wide binary systems are an important laboratory to test this underlying assumption. Here, we present the detailed chemical abundance patterns of 50 stars across 25 wide binary systems comprised of main-sequence stars of similar spectral type identified in Gaia DR2 with the aim of quantifying their level of chemical homogeneity. Using high-resolution spectra obtained with McDonald Observatory, we derive stellar atmospheric parameters and precise detailed chemical abundances for light/odd-Z (Li, C, Na, Al, Sc, V, Cu), α (Mg, Si, Ca), Fe-peak (Ti, Cr, Mn, Fe, Co, Ni, Zn), and neutron capture (Sr, Y, Zr, Ba, La, Nd, Eu) elements. Results indicate that 80 per cent (20 pairs) of the systems are homogeneous in [Fe/H] at levels below 0.02 dex. These systems are also chemically homogeneous in all elemental abundances studied, with offsets and dispersions consistent with measurement uncertainties. We also find that wide binary systems are far more chemically homogeneous than random pairings of field stars of similar spectral type. These results indicate that wide binary systems tend to be chemically homogeneous but in some cases they can differ in their detailed elemental abundances at a level of [X/H] ∼ 0.10 dex, overall implying chemical tagging in broad strokes can work.
Enstatite (MgSiO3) and forsterite (Mg2SiO4) monomers and dimers: highly detectable infrared and radioastronomical molecular building blocks
Authors: Valencia E Michael , Worth Charlie J , Fortenberry Ryan C 
Published: November 2019

ABSTRACT
Isolated MgSiO3 and Mg2SiO4 molecules are shown here to exhibit bright infrared (IR) features that fall close to unattributed astronomical lines observed toward objects known to possess crystalline enstatite and forsterite, minerals of the same respective empirical formulae. These molecules are therefore tantalizing candidates for explaining the origin of such features. Furthermore, the C2v monomer minima of each formula set have dipole moments on the order of 10.0 D or larger making them desirable candidates for radioastronomical observation as enabled through rotational spectroscopic data further provided in this high-level CCSD(T)-F12/cc-pVTZ-F12 quantum chemical study. Astrophysical detection of these molecules could inform the build-up pathways for creating nanocrystals from small molecules in protoplanetary discs or could show the opposite in explaining the destruction of enstatite and forsterite minerals in supernovae events or other high-energy stellar processes. This work also shows that the lowest energy isomers for molecules containing the geologically necessary elements Mg and Si have oxygen bonded between any of the other heavier elements making oxygen the glue for pre-mineralogic chemistry.
Know thy star, know thy planet: chemo-kinematically characterizing TESS targets
Authors: Carrillo Andreia , Hawkins Keith , Bowler Brendan P , Cochran William , Vanderburg Andrew 
Published: November 2019

ABSTRACT
The Transiting Exoplanet Survey Satellite (TESS) has already begun to discover what will ultimately be thousands of exoplanets around nearby cool bright stars. These potential host stars must be well understood to accurately characterize exoplanets at the individual and population levels. We present a catalogue of the chemo-kinematic properties of 2218 434 stars in the TESS Candidate Target List using survey data from Gaia DR2, APOGEE, GALAH, RAVE, LAMOST, and photometrically derived stellar properties from SkyMapper. We compute kinematic thin disc, thick disc, and halo membership probabilities for these stars and find that though the majority of TESS targets are in the thin disc, 4 per cent of them reside in the thick disc and &lt;1 per cent of them are in the halo. The TESS Objects of Interest in our sample also display similar contributions from the thin disc, thick disc, and halo with a majority of them being in the thin disc. We also explore metallicity and [α/Fe] distributions for each Galactic component and show that each cross-matched survey exhibits metallicity and [α/Fe] distribution functions that peak from higher to lower metallicity and lower to higher [α/Fe] from the thin disc to the halo. This catalogue will be useful to explore planet occurrence rates, among other things, with respect to kinematics, component membership, metallicity, or [α/Fe].
How complex is the cosmic web?
Authors: Vazza F 
Published: November 2019

ABSTRACT
The growth of large-scale cosmic structure is a beautiful exemplification of how complexity can emerge in our Universe, starting from simple initial conditions and simple physical laws. Using enzo cosmological numerical simulations, I applied tools from Information Theory (namely, ‘statistical complexity’) to quantify the amount of complexity in the simulated cosmic volume, as a function of cosmic epoch and environment. This analysis can quantify how much difficult to predict, at least in a statistical sense, is the evolution of the thermal, kinetic, and magnetic energy of the dominant component of ordinary matter in the Universe (the intragalactic medium plasma). The most complex environment in the simulated cosmic web is generally found to be the periphery of large-scale structures (e.g. galaxy clusters and filaments), where the complexity is on average ∼10–102 times larger than in more rarefied regions, even if the latter dominate the volume-integrated complexity of the simulated Universe. If the energy evolution of gas in the cosmic web is measured on a ≈100 ${\rm kpc}\, h^{-1}$ resolution and over a ≈200 $\rm Myr$ time-scale, its total complexity is in the range of $\sim 10^{16}\!-\!10^{17} \rm \,bits$, with little dependence on the assumed gas physics, cosmology, or cosmic variance.
Single-atom Sn-Zn pairs in CuO catalyst promote dimethyldichlorosilane synthesis
Authors: Shi Qi , Ji Yongjun , Chen Wenxin , Zhu Yongxia , Li Jing , Liu Hezhi , Li Zhi , Tian Shubo , Wang Ligen , Zhong Ziyi , Wang Limin , Ma Jianmin , Li Yadong , Su Fabing 
Published: November 2019

Abstract
Single-atom catalysts are of great interest because they can maximize the atom-utilization efficiency and generate unique catalytic properties; however, much attention has been paid to single-site active components, rarely to catalyst promoters. Promoters can significantly affect the activity and selectivity of a catalyst, even at their low concentrations in catalysts. In this work, we designed and synthesized CuO catalysts with atomically dispersed co-promoters of Sn and Zn. When used as the catalyst in the Rochow reaction for the synthesis of dimethyldichlorosilane, this catalyst exhibited much-enhanced activity, selectivity and stability compared with the conventional CuO catalysts with promoters in the form of nanoparticles. Density functional theory calculations demonstrate that single-atomic Sn substitution in the CuO surface can enrich surface Cu vacancies and promote dispersion of Zn to its atomic levels. Sn and Zn single sites as the co-promoters cooperatively generate electronic interaction with the CuO support, which further facilitates the adsorption of the reactant molecules on the surface, thereby leading to the superior catalytic performance.