bluuebunny/crossref_metadata_2025_split huggingface dataset:
Realizing Excellent Thermoelectric Performance of Sb2Te3 Based Segmented Leg with a Wide Temperature Range Using One‐Step Sintering
Authors: Xie Liangjun , Qin Haixu , Zhu Jianbo , Yin Li , Qin Dandan , Guo Fengkai , Cai Wei , Zhang Qian , Sui Jiehe 
Published: December 2019

AbstractTo achieve a wide temperature range and a high figure‐of‐merit, segmented assembling is considered as the most effective method based on optimized low‐temperature and medium‐temperature thermoelectric materials. In this work, divalent magnesium (Mg) as acceptor doping in both Bi0.5Sb1.5Te3 and indium (In) alloyed Sb2Te3 play an important role in improving thermoelectric performance, including enhanced power factor by balancing the electrical conductivity and Seebeck coefficient, reduced bipolar thermal conductivity by delaying occurrence of intrinsic excitation, and reduced lattice thermal conductivity due to point defects. Finally, both the figure‐of‐merit (ZT) value and the corresponding operating temperature range are improved. Typically, Mg0.01Bi0.5Sb1.49Te3 with a ZTave of 1.16 from 300 to 520 K and a ZTave of 0.84 for Mg0.02In0.1Sb1.88Te3 from 500 to 680 K are obtained. To further obtain wide‐temperature high ZT value, p‐type Mg0.01Bi0.5Sb1.49Te3/Mg0.02In0.1Sb1.88Te3 segmented leg with excellent interface bonding and extremely low contact resistivity is successfully fabricated by only one‐step sintering process. The corresponding average ZT value is up to 1.02 with a broad temperature range from 300 to 680 K, and a maximum theoretical conversion efficiency of 12.7% with a temperature difference of 380 K is obtained. This provides guidelines for high efficiency thermoelectric devices.
Deformation and water loss from solvent filled microcapsules under compressive loads
Authors: Finn Justin R. , Galvin Janine E. , Panday Rupen , Ashfaq Huda 
Published: December 2019

AbstractMicrocapsules filled with liquid solvents for CO2 absorption can be easily deformed due to their elastic polymer shells. We present a combination of experiments and model predictions to demonstrate that modest compressive forces can lead to significant capsule deformation and performance issues for this enabling technology. Contrary to expectations based on Raoult's law, capsules containing aqueous carbonate solution were found to lose water to flows of humidified nitrogen in centimeter‐scale packed beds. Water loss increased with gas velocity, suggesting compression was responsible for mass transfer, an interpretation supported by microscope images of deformed and broken capsules. A model for compression induced mass transfer under packed/fluidized bed operating conditions was developed and validated with the experimental data for a range of conditions (gas velocities, temperatures, humidities). Design criteria for future generations of microcapsules that will more effectively resist compression are evaluated.
Resilience to multiple stressors in an aquatic plant and its microbiome
Authors: O'Brien Anna M. , Yu Zhu Hao , Luo Dian‐ya , Laurich Jason , Passeport Elodie , Frederickson Megan E. 
Published: December 2019

PremiseOutcomes of species interactions, especially mutualisms, are notoriously dependent on environmental context, and environments are changing rapidly. Studies have investigated how mutualisms respond to or ameliorate anthropogenic environmental changes, but most have focused on nutrient pollution or climate change and tested stressors one at a time. Relatively little is known about how mutualisms may be altered by or buffer the effects of multiple chemical contaminants, which differ fundamentally from nutrient or climate stressors and are especially widespread in aquatic habitats.MethodsWe investigated the impacts of two contaminants on interactions between the duckweed Lemna minor and its microbiome. Sodium chloride (salt) and benzotriazole (a corrosion inhibitor) often co‐occur in runoff to water bodies where duckweeds reside. We tested three L. minor genotypes with and without the culturable portion of their microbiome across field‐realistic gradients of salt (3 levels) and benzotriazole (4 levels) in a fully factorial experiment (24 treatments, tested on each genotype) and measured plant and microbial growth.ResultsStressors had conditional effects. Salt decreased both plant and microbial growth and decreased plant survival more as benzotriazole concentrations increased. In contrast, benzotriazole did not affect microbial abundance and even benefited plants when salt and microbes were absent, perhaps due to biotransformation into growth‐promoting compounds. Microbes did not ameliorate duckweed stressors; microbial inoculation increased plant growth, but not at high salt concentrations.ConclusionsOur results suggest that multiple stressors matter when predicting responses of mutualisms to global change and that beneficial microbes may not always buffer hosts against stress.
Quercetin: A promising phytochemical for the treatment of glioblastoma multiforme
Authors: Tavana Erfan , Mollazadeh Hamid , Mohtashami Elmira , Modaresi Seyed Mohamad Sadegh , Hosseini Azar , Sabri Hamed , Soltani Arash , Javid Hossein , Afshari Amir R. , Sahebkar Amirhossein 
Published: December 2019

AbstractQuercetin, a plant‐derived flavonoid, is known for its antitumor and antiproliferative activities. Glioblastoma multiforme (GBM), as a highly aggressive cerebrum tumor, has a poor prognosis that is approximately 12 months despite standard therapy. Therefore, because of the low effectiveness of the current therapeutic strategies, additional medications in combination with chemotherapy and radiotherapy are needed, which could improve the prognosis of GBM patients. Multiple lines of evidence have shown that quercetin regulates many proteins involved in the cellular signal transduction in GBM. In this review, recent findings on the targeting of particular signaling pathways by quercetin and the subsequent effect on the pathogenesis of GBM are presented and discussed.
Brand switching and consumer identification with brands in the smartphones industry
Authors: Appiah Dominic , Ozuem Wilson , Howell Kerry E. , Lancaster Geoff 
Published: December 2019

AbstractBrand loyalty literature has mainly focused on how brands perform under normal market conditions. As the business environment grows more complex, globalised, and innovative, market disruptions become more prevalent. Taking a cognition‐based approach, this paper proposes that customers identify with brands to satisfy self‐definitional needs. A social constructivist perspective, using an inductive and case study strategy, was used. Data generation was based on purposeful sampling, and participants were chosen on the basis of their “lived” experience with the use of smartphones. Four major themes were identified in the purchase of smartphones: identity, satisfaction, brand loyalty, and brand switching. Participants' views suggested that this provides them with a sense of purpose and meaning, defining who they are and why they behave in specified ways in society, which increases their self‐esteem. Brand switching occurs when customers are motivated to review available alternatives in the marketplace due to a change in competitive activities. Socially, switching occurs when a customer's belief in a brand is externally influenced within the social setting. When the boundary between the “in‐group” and the “out‐group” is impermeable and changing, group membership is not realistic; social mobility is not a viable strategy to cope with identity threats.
Electron Paramagnetic Resonance and Magnetic Circular Dichroism Spectra of the Nitrogenase M Cluster Precursor Suggest Sulfur Migration upon Oxidation: A Proposal for Substrate and Inhibitor Binding
Authors: Rupnik Kresimir , Tanifuji Kazuki , Rettberg Lee , Ribbe Markus W. , Hu Yilin , Hales Brian J. 
Published: December 2019

AbstractThe active site of the nitrogen‐fixing enzyme Mo‐nitrogenase is the M cluster ([MoFe7S9C⋅R‐homocitrate]), also known as the FeMo cofactor or FeMoco. The biosynthesis of this highly complex metallocluster involves a series of proteins. Among them, NifB, a radical‐SAM enzyme, is instrumental in the assembly of the L cluster ([Fe8S9C]), a precursor and all‐iron core of the M cluster. In the absence of sulfite, NifB assembles a precursor form of the L cluster called the L* cluster ([Fe8S8C]), which lacks the final ninth sulfur. EPR and MCD spectroscopies are used to probe the electronic structures of the paramagnetic, oxidized forms of both the L and L* clusters, labeled LOx and [L*]Ox. This study shows that both LOx and [L*]Ox have nearly identical EPR and MCD spectra, thus suggesting that the two clusters have identical structures upon oxidation; in other words, a sulfur migrates away from LOx following oxidation, thereby rendering the cluster identical to [L*]Ox. It is proposed that a similar migration could occur to the M cluster upon oxidation, and that this is an instrumental part of both M cluster formation and nitrogenase substrate/inhibitor binding.
Esophageal candidiasis and its diagnosis
Authors: Bansal Raghav , Matos‐Casano Harold A. , Martinez‐Pitre Pedro 
Published: December 2019

AbstractThe concomitant use of two distinct sampling methods can enhance the diagnostic yield of esophageal candidiasis during upper endoscopy. Furthermore, when initial staining is inconclusive, the use of additional stains can help establish the diagnosis.
Prosthetic rehabilitation of the geriatric oncologic rhinectomy patient utilizing a craniofacial implant‐retained nasal prosthesis
Authors: Rosen Evan B. , Ahmed Zain Uddin , Huryn Joseph M. , Ganly Ian 
Published: December 2019

AbstractThis clinical report describes the expeditious treatment of a geriatric patient with squamous cell carcinoma of the nose treated with total rhinectomy, craniofacial implant placement, and a nasal prosthesis.
High‐dimensional spectral data classification with nonparametric feature screening
Authors: Li Chuan‐Quan , Xu Qing‐Song 
Published: December 2019

AbstractTwo nonparametric feature screening methods, namely, the Kolmogorov filter and model free, marginally measure the relationship between categorical response and predictor variables without the parametrical assumption. And they can select important variables in the high‐dimensional classification data. Random forest, as a classical nonparametric method, can solve various classification problems. In this paper, we combine the two nonparametric feature screening methods with random forest to handle with spectral data classification. And then other conventional classification methods are compared with ours on three spectral datasets. The comparison results illustrated that our methods have more desirable ability about classification performance and variable selection than other methods.
Facile Redox‐Induced Aromatic–Antiaromatic Interconversion of a β‐Tetracyano‐21,23‐Dithiaporphyrin under Ambient Conditions
Authors: Yamashita Ken‐ichi , Nakajima Kana , Honda Yusuke , Ogawa Takuji 
Published: December 2019

AbstractFacile redox‐induced aromatic–antiaromatic interconversions were accomplished by using β‐tetracyano‐21,23‐dithiaporphyrin (CN4S2Por). Introduced cyano groups not only increased the reduction potential of the porphyrin core but also stabilized the antiaromatic isophlorin (CN4S2Iph) by π conjugation. The reduction of CN4S2Por with hydrazine in polar solvents quantitatively affords CN4S2Iph, even under ambient conditions. CN4S2Iph retains a nearly planar conformation and exhibits considerable antiaromaticity. Aerobic oxidation of CN4S2Iph to CN4S2Por occurs in nonpolar solvents. This study was conducted to contribute to the understanding of the structure–antiaromaticity relationship.
Heart failure with preserved ejection fraction: New approaches to diagnosis and management
Authors: Upadhya Bharathi , Kitzman Dalane W. 
Published: December 2019

AbstractThe majority of older patients who develop heart failure (HF), particularly older women, have a preserved left ventricular ejection fraction (HFpEF). Patients with HFpEF have severe symptoms of exercise intolerance, poor quality‐of‐life, frequent hospitalizations, and increased mortality. The prevalence of HFpEF is increasing and its prognosis is worsening. However, despite its importance, our understanding of the pathophysiology of HFpEF is incomplete, and drug development has proved immensely challenging. Currently, there are no universally accepted therapies that alter the clinical course of HFpEF. Originally viewed as a disorder due solely to abnormalities in left ventricular (LV) diastolic function, our understanding has evolved such that HFpEF is now understood as a systemic syndrome, involving multiple organ systems, likely triggered by inflammation and with an important contribution of aging, lifestyle factors, genetic predisposition, and multiple‐comorbidities, features that are typical of a geriatric syndrome. HFpEF is usually progressive due to complex mechanisms of systemic and cardiac adaptation that vary over time, particularly with aging. In this review, we examine evolving data regarding HFpEF that may help explain past challenges and provide future directions to care patients with this highly prevalent, heterogeneous clinical syndrome.
Phase 2 study of LY3023414 in patients with advanced endometrial cancer harboring activating mutations in the PI3K pathway
Authors: Rubinstein Maria M. , Hyman David M. , Caird Imogen , Won Helen , Soldan Krysten , Seier Kenneth , Iasonos Alexia , Tew William P. , O’Cearbhaill Roisin E. , Grisham Rachel N. , Hensley Martee L. , Troso‐Sandoval Tiffany , Sabbatini Paul , Guillen Joyce , Selcuklu S. Duygu , Zimel Catherine , Torrisi Jean , Aghajanian Carol , Makker Vicky 
Published: December 2019

BackgroundPI3K pathway activation is common in endometrial cancer. We evaluated the safety and efficacy of the dual PI3K/mTOR inhibitor, LY3023414, in patients with advanced endometrial cancer harboring activating mutations in the PI3K pathway.MethodsWe conducted a single‐arm phase 2 study of monotherapy LY3023414. Eligible patients had advanced endometrial cancer of any grade, prior management with 1‐4 cytotoxic lines, and PI3K pathway activation prospectively defined as a loss‐of‐function PTEN alteration or activating alteration in PIK3CA, AKT1, PIK3R1, PIK3R2, or MTOR. The primary objective was best overall response rate (ORR) per RECIST 1.1.ResultsTwenty‐eight patients were treated; histologies included endometroid (39%), carcinosarcoma (25%), serous (21%), and mixed (14%). Patients were heavily pretreated, with a median of 2 prior cytotoxic lines (range, 1‐3). The most common alterations involved PIK3CA (68%), PTEN (43%), and PIK3R1 (32%). In the 25 efficacy‐evaluable patients, the ORR was 16% (90% CI, 7%‐100%), and the clinical benefit rate was 28% (90% CI, 16%‐100%). Four patients had a confirmed partial response, and 2 responses lasted for >9 months. The median progression‐free survival and overall survival were 2.5 months (95% CI, 1.2‐3.0) and 9.2 months (95% CI, 5.0‐15.9), respectively. The most common all‐grade treatment‐related adverse events were anemia (71%), hyperglycemia (71%), hypoalbuminemia (68%), and hypophosphatemia (61%). No correlation between molecular alterations and response was observed.ConclusionIn patients with heavily pretreated advanced endometrial cancer prospectively selected for tumors with activating PI3K pathway mutations, LY3023414 demonstrated modest single‐agent activity and a manageable safety profile.
Cytomorphology of hepatoblastoma with histological correlation and role of SALL4 immunocytochemistry in its diagnosis, subtyping, and prognostication
Authors: Nakra Tripti , Roy Maitrayee , Yadav Rajni , Agarwala Sandeep , Jassim Mohamed , Khanna Gaurav , Das Prasenjit , Jain Deepali , Mathur Sandeep R. , Iyer Venkateswaran K. 
Published: December 2019

BackgroundHepatoblastoma (HB) is the most common malignant pediatric liver tumor, and cytology material is often the only tissue available for evaluation before definitive therapy. Subcategorization of HB based on cytomorphological features thus carries an important role in its prognostication. Spalt‐like transcription factor 4 (SALL4), a marker of embryonic stem cells that is also found in the fetal liver, is reactivated in certain liver tumors. Limited studies have evaluated its role in HB. This study was aimed at evaluating the cytomorphological features of HB and assessing the utility of SALL4 immunocytochemistry (ICC) in its subtyping and prognostication.MethodsPretherapy fine‐needle aspiration smears from patients diagnosed with HB over a period of 9 years were retrieved. Aspirates were subclassified on the basis of the cytomorphology and were correlated with the histology wherever it was available. ICC for SALL4 was performed in 33 cases, and nuclear staining was considered positive.ResultsA total of 53 HB cases were included with 30 available postchemotherapy resection specimens. All the patients were diagnosed as epithelial HB on cytology, and the cases were subclassified as pure fetal (9 of 53), pure embryonal (2 of 53), or combined epithelial HB (42 of 53). There was good concordance between cytology and histology for subtyping. SALL4 immunostaining displayed strong and diffuse nuclear positivity in the embryonal component while focal and weak to negative staining in fetal cells.ConclusionsFine‐needle aspiration cytology serves as a rapid and effective tool for a correct diagnosis of HB before the implementation of chemotherapy, and SALL4 may serve as a useful diagnostic and prognostic marker.
Unusual Effect of Trace Water on the Structure and Activity of NixCo1−x Electrocatalysts for the Methanol Oxidation Reaction
Authors: Que Ronghui , Li Maolin , Yao Hong , Wang Xiuhua , Liao Fan , Shao Mingwang 
Published: December 2019

AbstractHighly active Ni‐based catalysts have attracted much attention but are still facing challenges owing to the immature synthetic method. Herein, polyhedral NixCo1−x alloy was prepared by a facile modified polyol method in which a trace amount of water could halve the particle size of the alloy. The Ni/Co ratios in NixCo1−x alloy strictly depended on the used amount of water owing to the different solubilities of the precursors. Among them, the Ni0.6Co0.4 nanoparticles obtained with 70 μL of deionized water exhibited the best performance in the methanol oxidation reaction with a peak current density of 116 mA cm−2 in the presence of 1 m NaOH+0.5 m CH3OH solution, which is higher than those of Ni0.7Co0.3 (80 mA cm−2) and Ni0.5Co0.5 (33 mA cm−2). The excellent performance of Ni0.6Co0.4 is attributed to the unique structure with appropriate Ni/Co ratio, which elongates the C−O bond in methanol and lowers the reaction free energy according to DFT calculations.
Unambiguous and precise correlation receiver for binary offset carrier modulated signal
Authors: Zhang Hua , Zuo Jiancun 
Published: December 2019

SummaryThe binary offset carrier (BOC) modulated signal can improve the positioning accuracy and increase the multipath resistance in global navigation satellite system (GNSS), and it may cause potential ambiguity in the process of signal acquisition and code tracking. In this paper, a simple but efficient unambiguous receiver is firstly proposed for multiple side‐peaks mitigation by implementing correlation of the received BOC signal with local sine wave instead of square wave used at the transmitter. Moreover, the potential degradation of sharpness of the nonlinear correlation induced by the sine wave is well compensated by optimizing the early‐to‐late spacing. The other reason leading to ambiguity is the multipath propagation, so we further propose a maximum likelihood (ML) estimator with Newton iteration method, where the received GNSS signal is modeled via the line‐of‐sight (LOS) component and the first‐arrived non‐line‐of‐sight (NLOS) component. Finally, the analytical expression of multipath propagation Cramer‐Rao bound is derived for the designed ML estimator. Simulation results indicate that compared with the conventional BOC modulation, the proposed sine wave receiver can achieve unambiguous and more precise code tracking performance and thus turns out to be more robust to multipath propagation.
Modeling and simulating the time‐varying movement in MIMO downlink by integrating ADS with Matlab
Authors: Gui Renzhou , Chen Tongjie 
Published: December 2019

SummaryCommunication systems and radar systems generally face problems caused by time‐varying motion, especially in the case of complex radio wave propagation in cities. Therefore, it is necessary to establish a suitable channel model to simulate the system to deal with these problems. This paper refers to the MIMO space‐time channel model in the 3rd Generation Partnership Project (3GPP) technical standard and proposes a method for modeling and simulating time‐varying motion in a MIMO downlink system according to the characteristics of the wireless channel and the transmission mode. The transmission function in MIMO downlink is derived to calculate the different Doppler frequency shift in the model based on 3GPP. By integrating ADS with Matlab software, environmental parameters and correlation coefficients can be manually set to simulate the downlink. During the simulation process, different modulation model bandwidths and channel conditions are set, and the configuration of the antenna parameters changes accordingly. Finally, the differences of simulation results are analyzed.
Co‐pelletization of edible fungi cultivation residue and pine sawdust: The optimal variable combinations
Authors: Li Weizhen , Bu Wenjing , Jiang Yang , Guo Weiwei , Wang Yan , Yin Xiuli 
Published: December 2019

AbstractCo‐pelletization of edible fungi cultivation residue and pine sawdust would help reduce the problems of residue disposal and resource limitation of pellet production. The objective of this work was to obtain the optimal variable formulations for pellets production from blends of Flammulina velutipes residue and Pinus sylvestris var. mongolica Litv. sawdust. Response surface methodology was employed to design the experiments. A uniaxial piston‐cylinder compression apparatus was used to produce pellets. The effects of variables of residue adding amount, moisture content, temperature, and pressure on responses of specific energy consumption, relaxed density, and Meyer Hardness were analyzed. Variance analysis of the data demonstrates that the differences between adjusted R2 and predicted R2 values are all within 0.2. The optimal variable combinations with residue content varying 0–40% were obtained according to the set response goals. Validation experiments were carried out using the same apparatus and relative percentage errors between the response predicted values and the experimental results were analyzed to improve the models. Most final errors were reduced below 10% indicating the high accuracy of the models. Further calculation of calorific value and ash content manifests that pellet performances could be improved by co‐pelletization.