bluuebunny/crossref_metadata_2025_split huggingface dataset:
Routine Postoperative Antithrombotic Therapy in Pediatric Liver Transplantation: Impact on Bleeding and Thrombotic Complications
Authors: Werner Maureen J. M. , de Kleine Ruben H. J. , de Boer Marieke T. , de Meijer Vincent E. , Scheenstra René , Verkade Henkjan J. , Bodewes Frank A. J. A. , Bontemps Sander T. H. , Reyntjens Koen M. E. M. , Dikkers Riksta , Lisman Ton , Porte Robert J. 
Published: January 2020

Abstract
Background Hepatic artery thrombosis (HAT) and portal vein thrombosis (PVT) are serious causes of morbidity and mortality after pediatric liver transplantation. To reduce thrombotic complications, routine antithrombotic therapy consisting of 1 week heparin followed by 3 months acetylsalicylic acid, was implemented in our pediatric liver transplant program in 2003. This study aimed to evaluate incidences of bleeding and thrombotic complications since the implementation of routine antithrombotic therapy and to identify risk factors for these complications.
Methods This retrospective cohort study includes 200 consecutive pediatric primary liver transplantations performed between 2003 and 2016. Uni- and multivariate logistic regression analysis, Kaplan–Meier method, and Cox regression analysis were used to evaluate recipient outcome.
Results HAT occurred in 15 (7.5%), PVT in 4 (2.0%), and venous outflow tract thrombosis in 2 (1.0%) recipients. Intraoperative vascular interventions (odds ratio [OR] 14.45 [95% confidence interval [CI] 3.75–55.67]), low recipient age (OR 0.81 [0.69–0.95]), and donor age (OR 0.96 [0.93–0.99]) were associated with posttransplant thrombosis. Clinically relevant bleeding occurred in 37%. Risk factors were high recipient age (OR 1.08 [1.02–1.15]), high Child–Pugh scores (OR 1.14 [1.02–1.28]), and intraoperative blood loss in mL/kg (OR 1.003 [1.001–1.006]). Both posttransplant thrombotic (hazard ratio [HR] 3.38 [1.36–8.45]; p = 0.009) and bleeding complications (HR 2.50 [1.19–5.24]; p = 0.015) significantly increased mortality.
Conclusion In 200 consecutive pediatric liver transplant recipients receiving routine postoperative antithrombotic therapy, we report low incidences of posttransplant vascular complications. Posttransplant antithrombotic therapy seems to be a valuable strategy in pediatric liver transplantation. Identified risk factors for bleeding and thrombotic complications might facilitate a more personalized approach in antithrombotic therapy.
Pneumocystis jiroveci
Authors: Fishman Jay A. 
Published: January 2020

Abstract
Pneumocystis jiroveci remains an important fungal pathogen in a broad range of immunocompromised hosts. The natural reservoir of infection remains unknown. Pneumocystis jiroveci Pneumonia (PJP) develops via airborne transmission or reactivation of inadequately treated infection. Nosocomial clusters of infection have been described among immunocompromised hosts. Subclinical infection or colonization may occur. Pneumocystis pneumonia occurs most often within 6 months of organ transplantation and with intensified or prolonged immunosuppression, notably with corticosteroids. Infection is also common during neutropenia and low-lymphocyte counts, with hypogammaglobulinemia, and following cytomegalovirus (CMV) infection. The clinical presentation generally includes fever, dyspnea with hypoxemia, and nonproductive cough. Chest radiographic patterns are best visualized by computed tomography (CT) scan with diffuse interstitial processes. Laboratory examination reveals hypoxemia, elevated serum lactic dehydrogenase levels, and elevated serum (1→3) β-D-glucan assays. Specific diagnosis is achieved using respiratory specimens with direct immunofluorescent staining; invasive procedures may be required and are important to avoid unnecessary therapies. Quantitative nucleic acid amplification is a useful adjunct to diagnosis but may be overly sensitive. Trimethoprim-sulfamethoxazole (TMP-SMX) remains the drug of choice for therapy; drug allergy should be documented before resorting to alternative therapies. Adjunctive corticosteroids may be useful early in the clinical course; aggressive reductions in immunosuppression may provoke immune reconstitution syndromes. Pneumocystis pneumonia (PJP) prophylaxis is recommended and effective for immunocompromised individuals in the most commonly affected risk groups.
Cryptococcosis
Authors: Zavala Sofia , Baddley John W. 
Published: January 2020

AbstractCryptococcosis has become an important infection in both immunocompromised and immunocompetent hosts. Although Cryptococcus is mainly recognized by its ability to cause meningoencephalitis, it can infect almost any organ of the human body, with pulmonary infection being the second most common disease manifestation. In cases of meningitis, symptom onset may be insidious, but headaches, fevers, or mental status changes should warrant diagnostic testing. Symptoms of pulmonary disease are nonspecific and may include fever, chills, cough, malaise, night sweats, dyspnea, weight loss, and hemoptysis. Due to protean manifestations of infection, diagnosis may be delayed or misdiagnosis may occur. Diagnosis typically is made by antigen testing of serum or cerebrospinal fluid or by culture or histopathology of infected tissues. A lumbar puncture with the measurement of opening pressure is recommended for patients with suspected or proven cryptococcosis. Treatment of cryptococcosis is based on the anatomical site of disease, severity of disease, and underlying immune status of the patient. Amphotericin B preparations plus 5-flucytosine is used as initial treatment of meningitis, disseminated infection, or moderate-to-severe pulmonary infection followed by fluconazole as a consolidation therapy. Fluconazole is effective for mild-to-moderate pulmonary infection. Important complications include elevated intracranial pressure and immune reconstitution syndrome, which may resemble active disease.
Information Extraction from Echocardiography Reports for a Clinical Follow-up Study—Comparison of Extracted Variables Intended for General Use in a Data Warehouse with Those Intended Specifically for the Study
Authors: Kaspar Mathias , Morbach Caroline , Fette Georg , Ertl Maximilian , Seidlmayer Lea K. , Krebs Jonathan , Dietrich Georg , Liman Leon , Puppe Frank , Störk Stefan 
Published: January 2020

Abstract
Background The interest in information extraction from clinical reports for secondary data use is increasing. But experience with the productive use of information extraction processes over time is scarce. A clinical data warehouse has been in use at our university hospital for several years, which also provides an information extraction of echocardiography reports developed for general use.
Objectives This study aims to illustrate the difficulties encountered, while using data from a preexisting information extraction process for a large clinical study. To compare the data from the preexisting process with the data obtained from a specially developed process designed to improve the quality and completeness of the study data.
Methods We extracted the echocardiography variables for 440 patients from the general-use information extraction of the data warehouse (678 reports). Then we developed an information extraction process for the same variables but specifically for this study, with the aim to extract as much information as possible from the text. The extracted data of both processes were compared with a newly created gold standard defined by a cardiologist with long-standing experience in heart failure.
Results Among 57 echocardiography variables considered relevant for the study, 50 were documented in the routine text reports and could be extracted. Twenty of the required variables were not provided by the general-use extraction process, some others were not provided correctly. The median macro F1-score (precision, recall) across the 30 variables for which values were extracted was 0.81 (0.94, 0.77). Across all 50 variables, as relevant for the study, median macro F1-score was only 0.49 (0.56, 0.46). Employing the study-specific approach considerably improved the quality and completeness of the variables, resulting in F1-scores of 0.97 (0.98, 0.96) across all variables.
Conclusion Data from information extractions can be used for large clinical studies. However, preexisting information extraction processes should be treated with caution, as the time and effort spent defining each variable in the information extraction process may not be clear.
Understanding the persistence of history-related issues in Sino–Japanese relations: from memory to forgetting
Authors: Gustafsson Karl 
Published: January 2020

AbstractDisputes over collective memory are a common source of bilateral friction in international politics. For example, differences over war memory have negatively impacted Sino–Japanese relations for many decades, despite apologies and other attempts to deal with the problems. Why are history-related issues so persistent? Existing explanations suggest, for example, that efforts to improve relations have been insufficient, or that collective memory is used instrumentally for political expediency. This article contributes to this discussion by shifting the conceptual focus from memory to forgetting. It argues that dominant notions offorgettingasfading awayanddenialoften facilitate an understanding of collective memory in terms of security. It suggests that a conceptualization of forgetting that sees it asinherent to all rememberingcould ameliorate tension over collective memory by making those involved in international memory politics recognize that not only others forget, but that they themselves also do so as they remember.
Experimental design of Cu content in weathering resistance steel for industrial atmosphere application
Authors: Yan Xuqiang , Yu Qiang , Guo Kai , Sun Rui , Zhu Siyuan , Wang Qingfeng , Gao Yuwei 
Published: January 2020

Abstract
In this paper, the effect of sulfur dioxide (SO2) on the corrosion behavior of weathering steel with different copper (Cu) contents in a simulated industrial environment was studied. The results showed that the corrosion occurred in three distinct stages with the corrosion kinetics characterized via the parameter of ‘n’. For the first and second stage with n > 1 and n < 1, the corrosion of weathering steel was accelerated and reduced, respectively. The third stage witnessed the minimum value of n, indicating a lowest corrosion rate. As the Cu content increased from 0.15% to 0.50%, the corrosion weight gained and corrosion rate remarkably decreased. In contrast, when the Cu contents increased from 0.50% to 0.70%, the corrosion rate began to slightly decrease. With the Cu addition, the stable α-FeOOH phase in the rust layer was refined, which increased the electrochemical impedance accordingly lowered the electrochemical reaction rate and ultimately enhanced the corrosion resistance. In this work, we have studied the corrosion mechanism of Cu element on the weathering steel in the industrial atmosphere, and studied the effect of Cu content on the corrosion resistance of weathering steel. The research shows that the content of the effect is not great, so the recommended amount of Cu in weathering steel is not more than 0.50%.
On the dependence of ionic transport on crystal orientation in NaSICON-type solid electrolytes
Authors: Ladenstein Lukas , Lunghammer Sarah , Wang Eric Y , Miara Lincoln J , Wilkening H Martin R , Redhammer Günther J , Rettenwander Daniel 
Published: January 2020

Abstract
The dependence of ionic transport on crystal orientations in NaSICON-type solid electrolytes is studied on flux-grown M3Sc2(PO4)3 (M = Na, Ag) single crystals with well-defined facets. Herein, we provide the first impedance spectroscopy study to characterize ion conduction along different crystallographic orientations in this important class of materials for electrochemical energy storage systems. Moreover, we used single crystal x-ray diffraction, differential scanning calorimetry, 23Na NMR spin-lattice relaxation measurements, and ab initio molecular dynamics simulations to study the interplay of structure and ion transport taking place at different length scales. We conclude that the phase behavior in NaSICON-type materials is strongly linked to ion diffusion. At room temperature, ionic conductivity is slightly anisotropic along the crystallographic orientations [001] and [100]. The slightly different activation energies are related to diffusion bottlenecks solely changing along [001]. This change is caused by anisotropic thermal lattice expansion. With increasing temperature, ion transport increasingly becomes isotropic finally resulting in an order-disorder phase transition from C2/c to R−3c. This phase transition is associated with a clear change in activation energy solely along [001]; it can be traced back to the increasing jump distance along this crystal orientation with temperature. Astonishingly, changing the ionic charge carrier, i.e. when going from Na+ to Ag+, shifts the phase transition temperature by 140 K towards lower temperature. The Arrhenius behavior remains, however, similar. This finding is related to the higher mobility of Ag+ in the NaSICON framework leading to isotropic ion diffusion at much lower temperatures. Overall, flux-grown M3Sc2(PO4)3 allowed us to show that ionic transport parameters and phase stability sensitively depend on crystal chemistry.
Encapsulation of Na4MnV(PO4)3 in robust dual-carbon framework rendering high-energy, durable sodium storage
Authors: Cai Congcong , Hu Ping , Zhu Ting , Chen Chengmeng , Hu Guangwu , Liu Zhenhui , Tian Yu , Chen Qiang , Zhou Liang , Mai Liqiang 
Published: January 2020

Abstract
Na4MnV(PO4)3 (NMVP) is a green, cheap, and high-energy cathode material for sodium-ion batteries. However, the low electrical conductivity severely limits its sodium storage performance. Herein, we report the spray-drying synthesis of robust and highly conductive reduced graphene oxide/amorphous carbon framework encapsulated NMVP (NMVP@rGO/AC) composite microspheres. The unique dual-carbon encapsulation architecture enables the NMVP@rGO/AC a high specific capacity (100 mAh g−1 at 100 mA g−1) with durable cyclability (capacity retention of 77.5% for 500 cycles). In situ XRD measurements reveal the reversible extraction/insertion of Na+ via unique solid-solution and two-phase reactions during de-sodiation/sodiation processes. This work provides a versatile platform for the construction of rGO/AC dual-carbon encapsulated active materials for electrochemical energy storage.
Injection of intense low-energy reactor-based positron beams into a supported magnetic dipole trap
Authors: Horn-Stanja J , Stenson E V , Stoneking M R , Singer M , Hergenhahn U , Nißl S , Saitoh H , Pedersen T Sunn , Dickmann M , Hugenschmidt C , Danielson J R 
Published: January 2020

Abstract
An increased low-energy positron flux is obtained from the reactor based NEPOMUC source when using its primary beam at energies as low as 20 eV. First experiments with this beam in a supported magnetic dipole trap resulted in the maximum current of injected positrons to date. According to single-particle simulations, remaining limitations in the injection efficiency, observed in the experiment, can be attributed to the spatial spread of the beam. In the first trapping measurements with this beam, top-down asymmetries in the electrostatic trapping potential are found to be detrimental to confinement.
Dorsal Hump Reduction Based on the New Ethmoidal Point Classification: A Clinical and Radiological Study of the Keystone Area in 138 Patients
Authors: Ferreira Miguel Gonçalves , Dias David Rodrigues , Cardoso Luis , Santos Mariline , Sousa Cecília A , Dourado Nuno , Santos Jorge , Amarante José 
Published: January 2020

Abstract

Background
Hump resection often requires reorganization of the keystone area.

Objectives
The authors sought to describe the importance of the point where the perpendicular plate of ethmoid joins the septal cartilage (SC) and the nasal bones (NB) (Ethmoidal point [E-point]) for hump resection surgical planning.

Methods
Measurements from mid-sagittal slices in nasal computed tomography scans taken in adult Caucasian patients between January 2015 and December 2018 were compared between patients seeking primary rhinoplasty due to a nasal hump and patients not seeking rhinoplasty (control group). Patients with previous nasal surgery or trauma, genetic or congenital facial disorders, and high septal deviation were excluded. The length of overlap between NB and SC was compared between the 2 groups. The location of the E-point in relation to the beginning of the nasal hump in the cephalocaudal direction was documented in the patients seeking rhinoplasty.

Results
The study population included 138 patients, 69 seeking and 69 not seeking rhinoplasty (96 females). The mean age was 32.9 years (range, 18-55 years). The length of overlap between NB and SC was similar between both groups (11.7 ± 3.3 vs 10.8 ± 3.3; P = 0.235). The E-point was located before the beginning of the nasal hump in 97% (67/69) of nasal hump patients, and it could be found a mean distance of 2.3 (±2.3) mm cephalic to the latter.

Conclusions
As a rule, the perpendicular plate of the ethmoid does not contribute to the nasal hump; therefore, only in exceptional cases should this be addressed while performing dorsal reduction.

Level of Evidence: 3
Exploring user perceptions of deletion in mobile instant messaging applications
Authors: Schnitzler Theodor , Utz Christine , Farke Florian M , Pöpper Christina , Dürmuth Markus 
Published: January 2020

Abstract
Contemporary mobile messaging provides rich text and multimedia functionality leaving detailed trails of sensitive user information that can span long periods of time. Allowing users to manage the privacy implications both on the sender and the receiver side can help to increase confidence in the use of communication applications. In October 2017, one of the mobile messengers with the largest user base, WhatsApp, introduced a feature to delete past messages from communication, both from the sender’s and the recipient’s devices. In this article, we compare the deletion features of 17 popular messaging applications. Implementations of these features widely differ across the applications we examined. We further report on a study with 125 participants conducted in a between-subjects design. We explore users’ preferences for deleting mobile messages, and we investigate how well they comprehend this functionality as implemented in popular messaging applications. We found statistically significant differences in users’ understanding of message deletion between our three test conditions, comprising WhatsApp, Facebook Messenger, and Skype. Eighty percent of participants in the WhatsApp condition could correctly assess the effects of deleting messages, compared to only 49% in the Skype condition. In addition, we provide insights into qualitative feedback received from our participants. Our findings indicate that message deletion is seen as a potentially useful feature that users may be able to use in different ways, including editing messages. Furthermore, users can more precisely estimate the capabilities of a deletion function when its effects are transparently explained in the application’s user interface.
Development of the Hong Kong Sign Language Sentence Repetition Test
Authors: Sze Felix , Wei Monica Xiao , Lam David 
Published: January 2020

Abstract
This paper presents the design and development of the Hong Kong Sign Language-Sentence Repetition Test (HKSL-SRT). It will be argued that the test offers evidence of discriminability, reliability, as well as practicality and can serve as an effective global measurement of individuals' proficiency in HKSL. The full version of the test consists of 40 signed sentences of increasing length and complexity. Specifically, we will evaluate the manual and non-manual components of these sentences to find out whether and to what extent they can differentiate three groups of deaf signers, namely, native signers, early learners and late learners. Statistical analyses show that the test scores based on a correct repetition of the manual signs of each sentence bear a significant negative correlation with signers' age of acquisition. Including the correct repetition of non-manuals in the scoring scheme can result in higher reliability and separation index of the test in the Rasch model. This paper will also discuss how psychometric measures of Rasch analysis, including the concept of fit and the rankings of items/persons in the Wright map, have been applied to the original list of the 40 sentence items for the development of a shortened test.
Epigenetic anticipation for food and reproduction
Authors: Leung Christelle , Angers Bernard , Bergeron Patrick 
Published: January 2020

Abstract
Physiological changes in anticipation of cyclic environmental events are common for the persistence of populations in fluctuating environments (e.g. seasons). However, dealing with sporadic resources such as the intermittent production of seed masting trees may be challenging unless reliable cues also make them predictable. To be adaptive, the anticipation of such episodic events would have to trigger the corresponding physiological response. Epigenetic modifications could result in such physiological anticipatory responses to future changes. The eastern chipmunk (Tamias striatus) is known to adjust its reproductive activity to match juvenile weaning with peak seed availability of masting trees, which are essential for their survival. We therefore expected that epigenetic changes would be linked to spring reproductive initiation in anticipation for beech seed availability in fall. We correlated the variation of DNA methylation profiles of 114 adult chipmunks captured in May with beech seeds abundance in September, over 4 years, for three distinct populations, as well as individuals sampled twice during reproductive and non-reproductive years. The significant correlation between spring epigenetic variation and the amount of food in the fall confirmed the phenotypic flexibility of individuals according to environmental fluctuations. Altogether, these results underlined the key role of epigenetic processes in anticipatory responses enabling organisms to persist in fluctuating environments.
Tangential stress at the core–mantle interface
Authors: Jault D 
Published: January 2020

SUMMARY
Fluctuations in the rotation rate of the solid Earth over periods from 5 to 100 yr result from exchanges of angular momentum between the fluid outer core and the solid mantle. The coupling mechanism mediating angular momentum transfer is not clear yet. Here, I revisit local Cartesian models for the pressure stress on a bumpy core–mantle interface. One common approach consists in analysing forced magnetohydrodynamic modes arising from the interaction between a steady flow along the core–mantle interface and boundary topography. The wave amplitude scales as the height ζ of corrugations and the pressure stress as ζ2. As expected from Newton’s third law, the tangential stress on the fluid is opposite to the tangential stress on the solid. It is exactly compensated by non-zero mean electromagnetic and Coriolis forces, which both result from interactions at infinity and not with the electrically insulating solid. Requiring zero net flux of mass and electrical current at infinity in order to better model closed systems necessitates to restore mean flow acceleration. This makes possible to investigate whether there is momentum transfer into the fluid interior or instead dissipation next to the boundary. Fluid stratification enhances the horizontal stress exerted by the pressure field on the core–mantle boundary but we have yet to describe the mechanism to transport momentum from the boundary into the fluid.