bluuebunny/crossref_metadata_2025_split huggingface dataset:
Copper(II) complexes bearing cyclobutanecarboxylate and pyridine ligands: a new series of dinuclear paddle-wheel complexes
Authors: Edelsbacher Philipp , Redhammer Günther , Monkowius Uwe 
Published: April 2020

AbstractFour members of a new series of paddle-wheel copper(II) complexes bearing cyclobutanecarboxylate as bridging ligand with pyridine derived ligands in axial positions are reported. They have been characterised by FTIR-ATR, UV–Vis spectroscopy, mass spectrometry, and single crystal X-ray diffraction. The synthesis is straight-forward by combining the carboxylic acid, copper(II) acetate, and a slight excess of a pyridine ligand. The molecular structures of three complexes reveal a coordination mode expected for such type of dinuclear copper(II) carboxylates.
Graphic abstract
Superconductivity of KFe2As2 Under Pressure: Ab Initio Study of Tetragonal and Collapsed Tetragonal Phases
Authors: Ptok Andrzej , Kapcia Konrad Jerzy , Sternik Małgorzata , Piekarz Przemysław 
Published: April 2020

AbstractKFe2As2 is one of the representatives of iron-based superconductors. Many interesting features distinguish this compound from other iron-based superconductors, e.g., a realization of the Pauli limit or an occurrence of the superconducting gap with nodal lines. Moreover, with increasing pressure, the isostructural phase transition from the tetragonal to collapsed tetragonal phase is experimentally observed. We discuss the structural, electronic, and superconducting properties of the KFe2As2 under pressure using the ab initio density functional theory (DFT) methods. We analyze the untypical properties of this superconductor considering, among others, the Fermi surfaces or the dependence of the anion height from the iron layer on the superconducting critical temperature.
Exposure to the environmental pollutant bisphenol A diglycidyl ether (BADGE) causes cell over-proliferation in Drosophila
Authors: Williams Michael J. , Cao Hao , Lindkvist Therese , Mothes Tobias J. , Schiöth Helgi B. 
Published: April 2020

AbstractBisphenol A diglycidyl ether (BADGE), a derivative of bisphenol A (BPA), is widely used in the manufacture of epoxy resins as well as a coating on food containers. Recent studies have demonstrated the adverse effects of BADGE on reproduction and development in rodents and amphibians, but how BADGE affects biological activity is not understood. To gain a better understanding of the biological effects of BADGE exposure during development, we used the model organism Drosophila melanogaster and performed whole transcriptome sequencing. Interestingly, when Drosophila are raised on food containing BADGE, genes having significantly increased transcript numbers are enriched for those involved in regulating cell proliferation, including DNA replication and cell cycle control. Furthermore, raising larvae on BADGE-containing food induces hemocyte (blood cell) over-proliferation. This effect can be stimulated with even lower concentrations of BADGE if the hemocytes are already primed for cell proliferation by the expression of dominant active Ras GTPase. We conclude that chronic exposure to the xenobiotic BADGE throughout development can induce cell proliferation.
respiTrack: Patient-specific real-time respiratory tumor motion prediction using magnetic tracking
Authors: Özbek Yusuf , Bárdosi Zoltán , Freysinger Wolfgang 
Published: April 2020

AbstractPurposeAn intraoperative real-time respiratory tumor motion prediction system with magnetic tracking technology is presented. Based on respiratory movements in different body regions, it provides patient and single/multiple tumor-specific prediction that facilitates the guiding of treatments.MethodsA custom-built phantom patient model replicates the respiratory cycles similar to a human body, while the custom-built sensor holder concept is applied on the patient’s surface to find optimum sensor number and their best possible placement locations to use in real-time surgical navigation and motion prediction of internal tumors. Automatic marker localization applied to patient’s 4D-CT data, feature selection and Gaussian process regression algorithms enable off-line prediction in the preoperative phase to increase the accuracy of real-time prediction.ResultsTwo evaluation methods with three different registration patterns (at fully/half inhaled and fully exhaled positions) were used quantitatively at all internal target positions in phantom: The statical method evaluates the accuracy by stopping simulated breathing and dynamic with continued breathing patterns. The overall root mean square error (RMS) for both methods was between$$0.32\pm 0.06~\hbox {mm}$$0.32±0.06mmand$$3.71\pm 0.79~\hbox {mm}$$3.71±0.79mm. The overall registration RMS error was$$0.6\pm 0.4~\hbox {mm}$$0.6±0.4mm. The best prediction errors were observed by registrations at half inhaled positions with minimum$$0.27\pm 0.02~\hbox {mm}$$0.27±0.02mm, maximum$$2.90\pm 0.72~\hbox {mm}$$2.90±0.72mm. The resulting accuracy satisfies most radiotherapy treatments or surgeries, e.g., for lung, liver, prostate and spine.ConclusionThe built system is proposed to predict respiratory motions of internal structures in the body while the patient is breathing freely during treatment. The custom-built sensor holders are compatible with magnetic tracking. Our presented approach reduces known technological and human limitations of commonly used methods for physicians and patients.
Assessing the Eutrophic Susceptibility of New Zealand Estuaries
Authors: Plew David R. , Zeldis John R. , Dudley Bruce D. , Whitehead Amy L. , Stevens Leigh M. , Robertson Barry M. , Robertson Ben P. 
Published: April 2020

AbstractWe developed a method to predict the susceptibility of New Zealand estuaries to eutrophication. This method predicts macroalgae and phytoplankton responses to potential nutrient concentrations and flushing times, obtained nationally from simple dilution models, a GIS land-use model and physical estuary properties. Macroalgal response was based on an empirically derived relationship between potential nitrogen concentrations and an established macroalgal index (EQR) and phytoplankton response using an analytical growth model. Intertidal area was used to determine which primary producer was likely to lead to eutrophic conditions within estuaries. We calculated the eutrophication susceptibility of 399 New Zealand estuaries and assigned them to susceptibility bands A (lowest expected impact) to D (highest expected impact). Twenty-seven percent of New Zealand estuaries have high or very high eutrophication susceptibilities (band C or D), mostly (63% of band C and D) due to macroalgae. The physical properties of estuaries strongly influence susceptibility to macroalgae or phytoplankton blooms, and estuaries with similar physical properties cluster spatially around New Zealand’s coasts. As a result, regional patterns in susceptibility are apparent due to a combination of estuary types and land use patterns. The few areas in New Zealand with consistently low estuary eutrophication susceptibilities are either undeveloped or have estuaries with short flushing times, low intertidal area and/or minimal tidal influx. Estuaries with conditions favourable for macroalgae are most at risk. Our approach provides estuary-integrated susceptibility scores likely to be of use as a regional or national screening tool to prioritise more in-depth estuary assessments, to evaluate likely responses to altered nutrient loading regimes and assist in developing management strategies for estuaries.
Still Life, a Mirror: Phasic memory and re-encounters with artworks
Authors: Mac Cumhaill Clare 
Published: April 2020

AbstractRe-encountering certain kinds of artworks in the present (re-listening to music, re-reading novels) can often occasion a kind of recollection akin to episodic recollection, but which may be better cast as ‘phasic’, at least insofar as one can be said to remember ‘what it was like’ to be oneself at some earlier stage or phase in one’s personal history. The kinds of works that prompt such recollection, I call ‘still lives’ - they are limited wholes whose formal properties are stable over time. In the first part of the paper, I spell out a way of making sense of the peculiar power that certain artworks have to occasion such recollection – it is, as I explain, a power orductusthat derives from the form of the artwork, though possession of such a power is not limited to art. I then detail three dimensions along which episodic recollection and phasic recollection as occasioned by re-encountering ‘still lives’ differ: metaphysical, phenomenological, and descriptive. In the second half, I explore a challenge for my account of phasic recollection, which in turn helps make more vivid my proposal as well as the spectral analogy at the heart of it: Just as one can see regions behind one by looking in the direction of a mirror located in the same space in which one is, sometimes by re-encountering certain kinds of artworks now, past intervals or phases ‘behind one’ can be ‘made present’ in a way that the paper aims to make plain. I also explain to what extent phasic recollection might be understood as a form of mental time travel, and what the attendant phenomenology of ‘transportation’ involves.
Foam EOR performance in homogeneous porous media: simulation versus experiments
Authors: Zoeir Ahmed , Simjoo Mohammad , Chahardowli Mohammad , Hosseini-Nasab Mojtaba 
Published: April 2020

AbstractIn petroleum industry after primary production, associated gas released from separators or an inert gas from an external resource is injected into reservoir to push the oil toward production wells. The most important issue in injection process is that highly mobile fluids prefer to channel through porous media outgoing the oil phase. To overcome this problem, foam is injected into reservoir to increase sweep efficiency via reducing mobility ratio. Foam EOR performance in porous media depends on several factors including foam texture, media characteristics and injection scenarios. In this work, we used $$ {\text{MATLAB}} $$MATLAB software to numerically simulate foam core flooding and also to fit $$ {\text{STARS}} $$STARS parameters with data achieved from two previously performed foam injection experiments in Bentheimer core samples with lengths of 6.7″ and 15.1″. Then we used $$ {\text{CMG}} $$CMG software to outstretch foam $$ {\text{EOR}} $$EOR simulations to more realistic 2D and 3D geometries which were designed to study override issue in slant formations and also well patterns influence on foam $$ {\text{EOR}} $$EOR performance. Results show that foam $$ {\text{EOR}} $$EOR performance in slant pay zones with severe dip angles highly depends on foam strength, pay zone thickness and injection well location. Results also show that since foam always exhibits shear thinning characteristic, well patterns which use higher number of wider spread injection wells can aid to improve oil extraction efficiency during foam flooding.
Prediction of in situ stresses, mud window and overpressure zone using well logs in South Pars field
Authors: Mousavipour Farshid , Riahi Mohammad Ali , Ghanbarnejad Moghanloo Hamed 
Published: April 2020

AbstractTo analyze the stability of the hydrocarbon wells, it is necessary to determine the exact value of in situ vertical and minimum and maximum horizontal components of the stress. Determination of the in situ stress in well planning is vital in detecting and preventing the occurrence of the instability in the walls of the drilled wells and fluid loss. Evaluation of the magnitude of in situ stress is required for optimizing drilling, well completion and reservoir simulation. Hence, access to the complete information on the in situ stresses while drilling is essential, especially in naturally fractured zones for prospective infill drilling in the field development plans. In this paper, the value of the in situ stress is determined for two wells drilled in the South Pars field, Iran. With information on the in situ stress and the pore pressure, the mud window for different depths of this well is obtained. The appropriate mud density and overpressure zone for safe drilling in the borehole are also determined.
Clinical characteristics of 145 patients with corona virus disease 2019 (COVID-19) in Taizhou, Zhejiang, China
Authors: Chen Qingqing , Zheng Zhencang , Zhang Chao , Zhang Xijiang , Wu Huijuan , Wang Jingdong , Wang Shuwei , Zheng Cheng 
Published: April 2020

Abstract
Objective
The aim of this study was to investigate the clinical characteristics of Corona Virus Disease 2019 in Taizhou, China.

Methods
A single center retrospective observational study was performed between Jan 1, 2020 and Mar 11, 2020 at Taizhou Public Health Medical Center, Zhejiang, China. All patients with confirmed Corona Virus Disease 2019 were enrolled, and their clinical data were gathered by reviewing electronic medical records. Outcomes of severely ill patients and non-severely ill patients were compared.

Results
Of 145 hospitalized patients with COVID-19, the average age was 47.5 years old (standard deviation, 14.6) and 54.5% were men. Hypertension was the most common comorbidity (15.2%), followed by diabetes mellitus (9.7%). Common symptoms included dry cough (81.4%), fever (75.2%), anorexia (42.8%), fatigue (40.7%), chest tightness (32.4%), diarrhea (26.9%) and dizziness (20%). According to imaging examination, 79.3% patients showed bilateral pneumonia, 18.6% showed unilateral pneumonia, 61.4% showed ground-glass opacity, and 2.1% showed no abnormal result. Compared with non-severely ill patients, severely ill patients were older (mean, years, 52.8 vs. 45.3, p < 0.01), had a higher proportion of diabetes mellitus (16.3% vs. 6.9%, p = 0.08), had a higher body mass index (mean, 24.78 vs. 23.20, p = 0.02) and were more likely to have fever (90.7% vs. 68.6%, p = 0.01), anorexia (60.5% vs. 35.3%, p = 0.01), chest tightness (60.5% vs.20.6%, p < 0.01) and dyspnea (7.0% vs. 0%, p = 0.03). Of the 43 severely ill patients, 6 (14%) received high-flow nasal cannula oxygen therapy, and 1 (2.3%) received invasive mechanical ventilation.

Conclusions
Older patients or patients with comorbidities such as obesity or diabetes mellitus were more likely to have severe condition. Treatments of COVID-19 is still experimental and more clinical trials are needed.
Antimicrobial stewardship in the outpatient setting: A review and proposed framework
Authors: Marcelin Jasmine R. , Chung Philip , Van Schooneveld Trevor C. 
Published: April 2020

AbstractAntimicrobial misuse is still a significant problem, and most inappropriate use occurs in the outpatient setting. In this article, we provide a review of available literature on outpatient antimicrobial stewardship in primary care settings, and we propose a novel implementation framework.
Combining labour market and unemployment policies with environmental sustainability? A cross-national study on ecosocial innovations
Authors: Stamm Ingo , Matthies Aila-Leena , Hirvilammi Tuuli , Närhi Kati 
Published: April 2020

AbstractLabour market and unemployment policies in particular are rarely connected to issues of environmental sustainability. In the present article, the link is examined by focusing on ecosocial innovations in four European countries – Finland, Germany, Belgium and Italy. These innovations are small-scale associations, cooperatives or organizations that create new integrative practices combining both social and environmental goals. By asking how their social practices are linked with labour market and unemployment policies, we explore the scope for new ecosocial policies. The results of this cross-national case study lead to three lessons to be learnt for a future ecosocial welfare state: at the sectoral level, organizational level and individual level. In summary, many valuable ideas, instruments and programmes towards sustainability already exist in the field, but they are not yet integrated in the current labour market and unemployment policies.
Association of extent of cannabis use and psychotic like intoxication experiences in a multi-national sample of first episode psychosis patients and controls
Authors: Sami Musa , Quattrone Diego , Ferraro Laura , Tripoli Giada , Cascia Erika La , Gayer-Anderson Charlotte , Selten Jean-Paul , Arango Celso , Bernardo Miguel , Tarricone Ilaria , Tortelli Andrea , Gatto Giusy , del Peschio Simona , Del-Ben Cristina Marta , Rutten Bart P. , Jones Peter B. , van Os Jim , de Haan Lieuwe , Morgan Craig , Lewis Cathryn , Bhattacharyya Sagnik , Freeman Tom P. , Lynskey Michael , Murray Robin M. , Forti Marta Di 
Published: April 2020

AbstractBackgroundFirst episode psychosis (FEP) patients who use cannabis experience more frequent psychotic and euphoric intoxication experiences compared to controls. It is not clear whether this is consequent to patients being more vulnerable to the effects of cannabis use or to their heavier pattern of use. We aimed to determine whether extent of use predicted psychotic-like and euphoric intoxication experiences in patients and controls and whether this differs between groups.MethodsWe analysed data on patients who had ever used cannabis (n = 655) and controls who had ever used cannabis (n = 654) across 15 sites from six countries in the EU-GEI study (2010–2015). We used multiple regression to model predictors of cannabis-induced experiences and to determine if there was an interaction between caseness and extent of use.ResultsCaseness, frequency of cannabis use and money spent on cannabis predicted psychotic-like and euphoric experiences (p ⩽ 0.001). For psychotic-like experiences (PEs) there was a significant interaction for caseness × frequency of use (p < 0.001) and caseness × money spent on cannabis (p = 0.001) such that FEP patients had increased experiences at increased levels of use compared to controls. There was no significant interaction for euphoric experiences (p > 0.5).ConclusionsFEP patients are particularly sensitive to increased psychotic-like, but not euphoric experiences, at higher levels of cannabis use compared to controls. This suggests a specific psychotomimetic response in FEP patients related to heavy cannabis use. Clinicians should enquire regarding cannabis related PEs and advise that lower levels of cannabis use are associated with less frequent PEs.
Influnce of the beta-adrenergic agonist clenbuterol on plasma catecholamines and lymphocyte beta-receptors
Authors: Bondy B. , Ackenheil M. , Laakmann G. , Munz H.T. 
Published: April 2020

SummaryThe influence of subchronic application of the β-adrenergic agonist clenbuterol on plasma norepinephrine (NE), epinephrine (E) and β-receptors on lymphocytes was investigated in 8 male, healthy volunteers. Treatment with clenbuterol (0.04 mg/day) for 6 days induced significant reduction of β-receptor specific binding in 7 of the 8 subjects with a mean decrease of 40% (p < 0.01) with no changes in affinity. Concomitantly an increase in the plasma NE concentration was observed (mean 50%, p < 0.01), but no significant overall alteration of E concentration. Our results suggest that β-adrenergic agonists exercise a similar effect on the peripheral adrenergic system and on the adrenergic system in the brain.
Méthodologie des essais thérapeutiques pour appréhender les posologies optimales des benzodiazépines
Authors: Guelfi J.D. 
Published: April 2020

RésuméLa notion de posologie optimale des benzodiazépines doit être discutée, Elle varie en effet selon les indications thérapeutiques, les malades et les prescripteurs (praticiens généralistes ou spécialistes). Pour ces produits - dont les posologies idéales demeurent individuelles - la moyenne des posologies optimales n’a guère de signification clinique. En revanche, des courbes «d’utilité thérapeutique» doivent être établies dans chaque indication, en identifiant pour différentes posologies l’importance des effets observés (thérapeutiques et indésirables). Cette connaissance des posologies utiles commence dès les essais préciiniques et ceux de pharmacologie humaine (études pharmacocinétiques et électrophysiologiques comme l’E.E.G. quantitatif en laboratoire de sommeil). Elle est utilement complétée par les essais contrôlés ultérieurs. Les posologies particulièrement étudiées au cours de la phase II vont de celles responsables d’un effet supérieur à celui d’un placebo à celle d’un effet considéré comme «maximal». Cette dermère est plus facilement identifiable pour des produits à effet hypnotique prédominant (à des doses généralement bien supportées) que pour celles à visée anxiolytique. Certains plans expérimentaux revêtent dans ces indications un intérêt particulier, notamment certains protocoles intensifs chez un petit nombre de sujets (volontaires sains, insomniaques situationnels ou chroniques).Au cours des essais de phase III, plusieurs types d’étude peuvent être envisagés : des groupes parallèles homogènes (quant à la nature de l’insomnie ou de l’anxiété) randomisés où plusieurs posologies présumées efficacies sont comparées mais aussi des essais au cours desquels des doses croissantes sont successivement prescrites de façon codifiée à l’ensemble des patients. C’est en fonction de la gravité de la symptomatologie que l’on définit l’intensité d’un effet secondaire ou résiduel «acceptable» (altération des performances, exploration des fonctions mnésiques, etc…).Lors de la phase IV, la simple étude des posologies couramment utilisées par les praticiens permet d’élaborer des hypothèses quant aux posologies présumées optimales dans des indications particulières comme l’anxiété généralisée, l’alcoolisme, l’anxiété concomitante des psychoses, l’anxiété des attaques de panique voire celle des affections psychosomatiques.Mais les seules techniques susceptibles de vérifier ces hypothèses restent des études comparatives randomisées de groupes parallèles de patients traités par différentes posologies.