bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Method to Reduce Head-Disk Interface (HDI) Degradation Risk During Thermal Asperity (TA) Mapping in a Hard Disk Drive
Authors: Srivastava Abhishek , Rai Rahul , Venkatesh Karthik , Knigge Bernhard 
Published: September 2020

Abstract
One of the issues in thermal asperity (TA) detection using an embedded contact sensor (ECS) is the degradation caused to the read/write elements of the head while interacting with the TA. We propose a method to reduce such head-disk interaction (HDI) during TA detection and classification by flying higher at low thermal fly-height control (TFC) power, which minimizes the interaction of the TA with the head. The key idea is to scan the head at higher fly height, but with higher ECS bias voltage. Initial experiments have shown that the TA count follows a negative cubic relationship with the backoff at various bias levels, and that it follows a square relationship with bias at various backoff levels. Using a sample set, the calibration curves i.e. the golden relationship between these parameters can be established. Using these, one can start the TA detection at the highest backoff and high ECS bias, and start to estimate the nominal TA count. By mapping out these TAs and ensuring the head does not fly over them again to prevent HDI, the fly height can then be lowered, and the rest of the TA cluster can be scanned. Following this method iteratively, the entire TA cluster can be mapped out with minimal interaction with the head. Although this method entails an increase in the test time to detect and map all TAs, compared to detecting them with TFC being on, this can help improve the reliability of the drive by protecting the sensitive read/write elements especially for energy assisted recording from HDI.
HEROIC: a 5-year observational cohort study aimed at identifying novel factors that drive diabetic kidney disease: rationale and study protocol
Authors: Mccafferty Kieran , Caplin Ben , Knight Sinead , Hockings Paul , Wheeler David , Fan Stanley L , Hulthe Johannes , Kleta Robert , Ashman Neil , Papastefanou Vasilios , Mehta Hemal , Salama Alan , Hadzovic Sinela , Chowdhury Tahseen Ahmad , Jarl Lisa , Unwin Robert , Challis Benjamin , Sundgren Anna K , Yaqoob Muhammad Magdi 
Published: September 2020

IntroductionDiabetic kidney disease (DKD) is the leading cause of end-stage kidney disease worldwide and a major cause of premature mortality in diabetes mellitus (DM). While improvements in care have reduced the incidence of kidney disease among those with DM, the increasing prevalence of DM means that the number of patients worldwide with DKD is increasing. Improved understanding of the biology of DKD and identification of novel therapeutic targets may lead to new treatments. A major challenge to progress has been the heterogeneity of the DKD phenotype and renal progression. To investigate the heterogeneity of DKD we have set up The East and North London Diabetes Cohort (HEROIC) Study, a secondary care-based, multiethnic observational study of patients with biopsy-proven DKD. Our primary objective is to identify histological features of DKD associated with kidney endpoints in a cohort of patients diagnosed with type 1 and type 2 DM, proteinuria and kidney impairment.Methods and analysisHEROIC is a longitudinal observational study that aims to recruit 500 patients with DKD at high-risk of renal and cardiovascular events. Demographic, clinical and laboratory data will be collected and assessed annually for 5 years. Renal biopsy tissue will be collected and archived at recruitment. Blood and urine samples will be collected at baseline and during annual follow-up visits. Measured glomerular filtration rate (GFR), echocardiography, retinal optical coherence tomography angiography and kidney and cardiac MRI will be performed at baseline and twice more during follow-up. The study is 90% powered to detect an association between key histological and imaging parameters and a composite of death, renal replacement therapy or a 30% decline in estimated GFR.Ethics and disseminationEthical approval has been obtained from the Bloomsbury Research Ethics Committee (REC 18-LO-1921). Any patient identifiable data will be stored on a password-protected National Health Services N3 network with full audit trail. Anonymised imaging data will be stored in a ISO27001-certificated data warehouse.Results will be reported through peer-reviewed manuscripts and conferences and disseminated to participants, patients and the public using web-based and social media engagement tools as well as through public events.
How effective is undergraduate palliative care teaching for medical students? A systematic literature review
Authors: Boland Jason W , Brown Megan E L , Duenas Angelique , Finn Gabrielle M , Gibbins Jane 
Published: September 2020

Palliative care is central to the role of all clinical doctors. There is variability in the amount and type of teaching about palliative care at undergraduate level. Time allocated for such teaching within the undergraduate medical curricula remains scarce. Given this, the effectiveness of palliative care teaching needs to be known.ObjectivesTo evaluate the effectiveness of palliative care teaching for undergraduate medical students.DesignA systematic review was prepared according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidance. Screening, data extraction and quality assessment (mixed methods and Cochrane risk of bias tool) were performed in duplicate.Data sourcesEmbase, MEDLINE, PsycINFO, Web of Science, ClinicalTrials.gov, Cochrane and grey literature in August 2019. Studies evaluating palliative care teaching interventions with medical students were included.Results1446 titles/abstracts and 122 full-text articles were screened. 19 studies were included with 3253 participants. 17 of the varied methods palliative care teaching interventions improved knowledge outcomes. The effect of teaching on clinical practice and patient outcomes was not evaluated in any study.ConclusionsThe majority of palliative care teaching interventions reviewed improved knowledge of medical students. The studies did not show one type of teaching method to be better than others, and thus no ‘best way’ to provide teaching about palliative care was identified. High quality, comparative research is needed to further understand effectiveness of palliative care teaching on patient care/clinical practice/outcomes in the short-term and longer-term.PROSPERO registration numberCRD42018115257.
Yorkshire Lung Screening Trial (YLST): protocol for a randomised controlled trial to evaluate invitation to community-based low-dose CT screening for lung cancer versus usual care in a targeted population at risk
Authors: Crosbie Philip AJ , Gabe Rhian , Simmonds Irene , Kennedy Martyn , Rogerson Suzanne , Ahmed Nazia , Baldwin David R , Booton Richard , Cochrane Ann , Darby Michael , Franks Kevin , Hinde Sebastian , Janes Sam M , Macleod Una , Messenger Mike , Moller Henrik , Murray Rachael L , Neal Richard D , Quaife Samantha L , Sculpher Mark , Tharmanathan Puvanendran , Torgerson David , Callister Matthew EJ 
Published: September 2020

IntroductionLung cancer is the world’s leading cause of cancer death. Low-dose computed tomography (LDCT) screening reduced lung cancer mortality by 20% in the US National Lung Screening Trial. Here, we present the Yorkshire Lung Screening Trial (YLST), which will address key questions of relevance for screening implementation.Methods and analysisUsing a single-consent Zelen’s design, ever-smokers aged 55–80 years registered with a general practice in Leeds will be randomised (1:1) to invitation to a telephone-based risk-assessment for a Lung Health Check or to usual care. The anticipated number randomised by household is 62 980 individuals. Responders at high risk will be invited for LDCT scanning for lung cancer on a mobile van in the community. There will be two rounds of screening at an interval of 2 years. Primary objectives are (1) measure participation rates, (2) compare the performance of PLCOM2012(threshold ≥1.51%), Liverpool Lung Project (V.2) (threshold ≥5%) and US Preventive Services Task Force eligibility criteria for screening population selection and (3) assess lung cancer outcomes in the intervention and usual care arms. Secondary evaluations include health economics, quality of life, smoking rates according to intervention arm, screening programme performance with ancillary biomarker and smoking cessation studies.Ethics and disseminationThe study has been approved by the Greater Manchester West research ethics committee (18-NW-0012) and the Health Research Authority following review by the Confidentiality Advisory Group. The results will be disseminated through publication in peer-reviewed scientific journals, presentation at conferences and on the YLST website.Trial registration numbersISRCTN42704678andNCT03750110.
Thermostatistics with an invariant infrared cutoff
Authors: Roushan M. , Nozari K. 
Published: September 2020

AbstractQuantum gravitational effects may affect the large scale dynamics of the universe. Phenomenologically, quantum gravitational effect at large distances can be encoded in an extended uncertainty principle that admits a minimal measurable momentum/energy or a maximal length. This maximal length can be considered as the size of the cosmological horizon today. In this paper we study thermostatistics of an expanding universe as a gaseous system and in the presence of an invariant infrared cutoff. We also compare the thermostatistics of different eras of the evolution of the universe in two classes, Fermions and Bosons.
LINKING HARMONIOUS CSR AND FINANCIAL INCLUSION: THE MODERATING EFFECTS OF FINANCIAL LITERACY AND INCOME
Authors: SINGH KULDEEP , MISRA MADHVENDRA 
Published: September 2020

This study focuses on the effect of Corporate Social Responsibility (CSR) on financial inclusion behavior in rural communities. CSR in the domain of community engagement, education and livelihood initiatives, which are all referred to as ‘harmonious CSR’ in the paper. This study further explores the moderating influence of financial literacy and income on harmonious CSR-financial inclusion linkages. A field survey of 344 rural households (CSR beneficiaries) was conducted in two districts of Uttar Pradesh, India. This study follows a two-stage approach. First, a theoretical model is constructed on the basis of a strategic review of literature in the field of social science (social work, rural development and development studies). Second, confirmatory factor analysis (CFA) is performed, followed by a hierarchical regression model to determine underlying associations. Findings reveal that harmonious CSR has a significantly positive impact on financial inclusion in the Indian rural sector. The moderating effect of financial literacy is also reflected in CSR-financial inclusion linkages. However, income is not found to have any moderating influence on the relationship between harmonious CSR and financial inclusion. Finally, this study is in favor of deepening the influence of the financial institutions so that policymakers can make informed decisions about maintaining a sustainable economic environment, especially, in the context of the rural sector where such steps are desperately needed.
Multiplex Immunofluorescence in Formalin-Fixed Paraffin-Embedded Tumor Tissue to Identify Single-Cell–Level PI3K Pathway Activation
Authors: Stopsack Konrad H. , Huang Ying , Tyekucheva Svitlana , Gerke Travis A. , Bango Clyde , Elfandy Habiba , Bowden Michaela , Penney Kathryn L. , Roberts Thomas M. , Parmigiani Giovanni , Kantoff Philip W. , Mucci Lorelei A. , Loda Massimo 
Published: September 2020

Abstract

Purpose:
Identifying cancers with high PI3K pathway activity is critical for treatment selection and eligibility into clinical trials of PI3K inhibitors. Assessments of tumor signaling pathway activity need to consider intratumoral heterogeneity and multiple regulatory nodes.

Experimental Design:
We established a novel, mechanistically informed approach to assessing tumor signaling pathways by quantifying single-cell–level multiplex immunofluorescence using custom algorithms. In a proof-of-concept study, we stained archival formalin-fixed, paraffin-embedded (FFPE) tissue from patients with primary prostate cancer in two prospective cohort studies, the Health Professionals Follow-up Study and the Physicians’ Health Study. PTEN, stathmin, and phospho-S6 were quantified on 14 tissue microarrays as indicators of PI3K activation to derive cell-level PI3K scores.

Results:
In 1,001 men, 988,254 tumor cells were assessed (median, 743 per tumor; interquartile range, 290–1,377). PI3K scores were higher in tumors with PTEN loss scored by a pathologist, higher Gleason grade, and a new, validated bulk PI3K transcriptional signature. Unsupervised machine-learning approaches resulted in similar clustering. Within-tumor heterogeneity in cell-level PI3K scores was high. During long-term follow-up (median, 15.3 years), rates of progression to metastases and death from prostate cancer were twice as high in the highest quartile of PI3K activation compared with the lowest quartile (hazard ratio, 2.04; 95% confidence interval, 1.13–3.68).

Conclusions:
Our novel pathway-focused approach to quantifying single-cell–level immunofluorescence in FFPE tissue identifies prostate tumors with PI3K pathway activation that are more aggressive and may respond to pathway inhibitors.
Trajectory of Risk-Standardized Survival Rates for In-Hospital Cardiac Arrest
Authors: Qazi Abdul H. , Chan Paul S. , Zhou Yunshu , Vaughan-Sarrazin Mary , Girotra Saket ,   For the American Heart Association Get With the Guidelines—Resuscitation Investigators
Published: September 2020

Background:
A hospital’s risk-standardized survival rate (RSSR) for in-hospital cardiac arrest has emerged as an important metric to benchmark and incentivize hospital resuscitation quality. We examined whether hospital performance on the RSSR metric was stable or dynamic year-over-year and whether low-performing hospitals were able to improve survival outcomes over time.

Methods and Results:
We used data from 84 089 adult patients with an in-hospital cardiac arrest from 166 hospitals with continuous participation in Get With The Guidelines–Resuscitation from 2012 to 2017. A 2-level hierarchical regression model was used to compute RSSRs during a baseline (2012–2013) and two follow-up periods (2014–2015 and 2016–2017). At baseline, hospitals were classified as top-, middle-, and bottom-performing if they ranked in the top 25%, middle 50%, and bottom 25%, respectively, on their RSSR metric during 2012 to 2013. We compared hospital performance on RSSR during follow-up between top, middle, and bottom-performing hospitals’ at baseline. During 2012 to 2013, 42 hospitals were identified as top-performing (median RSSR, 31.7%), 82 as middle-performing (median RSSR, 24.6%), and 42 as bottom-performing (median RSSR, 18.7%). During both follow-up periods, >70% of top-performing hospitals ranked in the top 50%, a substantial proportion remained in the top 25% of RSSR during 2014 to 2015 (54.6%) and 2016 to 2017 (40.4%) follow-up periods. Likewise, nearly 75% of bottom-performing hospitals remained in the bottom 50% during both follow-up periods, with 50.0% in the bottom 25% of RSSR during 2014 to 2015 and 40.5% in the bottom 25% during 2016 to 2017. While percentile rankings were generally consistent over time at ≈45% of study hospitals, ≈1 in 5 (21.4%) bottom-performing hospitals showed large improvement in percentile rankings over time and a similar proportion (23.7%) of top-performing hospitals showed large decline in percentile rankings compared with baseline.

Conclusions:
Hospital performance on RSSR during baseline period was generally consistent over 4 years of follow-up. However, 1 in 5 bottom-performing hospitals had large improvement in survival over time. Identifying care and quality improvement innovations at these sites may provide opportunities to improve in-hospital cardiac arrest care at other hospitals.
Participants’ lived experience of pursuing personal goals in the Illness Management and Recovery program
Authors: Jensen Sofie B , Eplov Lene Falgaard , Mueser Kim T , Petersen Kirsten Schultz 
Published: September 2020

Background: The Illness Management and Recovery (IMR) program is designed to support people diagnosed with severe mental illness in developing tailored illness-management skills and to pursue personal goals. Although IMR is a goal-oriented program, little is know about the participants’ experience of goal-setting as part of IMR. Aim: To describe participants’ lived experience of personal goal-setting as part of the Illness Management and Recovery program (IMR). Method: A descriptive, phenomenological research design was employed with individual interviews. Results: IMR helped the participants break down their personal goals into manageable short-term goals. The main themes were as follows: ‘We were guided to set clearer and specific goals in IMR’, ‘We were encouraged to pursue our personal goals in IMR’ and ‘We were encouraged and supported to resume work on our goals when we stopped making progress’. The findings emphasise goal-setting in IMR as a means to instilling hope for the future and work on goals. Conclusions: The participants learned to identify, articulate and initiate work towards short- and long-term goals when guided by the instructor and supported by peers in the IMR group. Goal-setting is a useful method for breaking down personal recovery goals into a practical short-term goals and motivating participants to pursue them. The findings indicate goal-setting is an important part of the IMR-program, but suggest that flexibility in goal-setting is needed, especially in the time required to achieve personal goals.
Mechanical evaluation of the “Hüfner hand” prosthesis
Authors: Smit Gerwin 
Published: September 2020

Background:
Current body-powered hands have very low acceptance rates. They also require high activation forces. In the past, a high acceptance rate was reported for the then-available Hüfner hand, a hand which could be controlled by relatively low activation forces.

Objective:
The aim of this study was to measure and quantify the mechanical performance of the Hüfner hand.

Study design:
Mechanical evaluation.

Methods:
Two versions of the Hüfner hand were tested using a mechanical test bench. Forces and displacements were measured under four different glove conditions (no glove, leather, polyvinyl chloride (PVC), silicone). The measured results were compared to data from currently available voluntary-closing hands.

Results:
The Hüfner hand required 132–170 Nmm of work and 78–104 N cable force to pinch 15 N. The overall mechanical performance of the Hüfner hands is better than currently available body-powered hands.

Conclusion:
The mechanical performance of the Hüfner hand was measured and quantified. Mechanical testing results show that the Hüfner hand has better mechanical performance than current body-powered hands. This may have contributed to its reported high acceptance rates. The design of the Hüfner hand, combined with data presented in this study, can serve as guidelines for the design of a new generation of body-powered hands.
Making working from home work: reflections on adapting to change
Authors: Khanna Rahul , Murnane Tess , Kumar Shakira , Rolfe Timothy , Dimitrieski Stephanie , McKeown Michael , Ejareh dar Maryam , Gavson Laura , Gandhi Charu 
Published: September 2020

Objectives: During the COVID-19 pandemic, our mental health service experimented with working from home. The flexibility of this practice can enable improved efficiency, staff well-being and expanded operating hours in the longer term. This paper shares our experiences and makes recommendations for being a part of and leading distributed clinical teams. Conclusions: We saw a 3% increase in total appointment bookings and a 7% reduction in cancellations/non-attendance compared to the same period in 2019. Based on our experience and the literature, effective distributed teams have leaders that connect via video at least weekly; focus on transparency and output over micromanagement; prioritise staff relationships and err towards overcommunication.
Velopharyngeal Muscle Morphology in Children With Unrepaired Submucous Cleft Palate: An Imaging Study
Authors: Schenck Graham C. , Perry Jamie L. , O’Gara Mary M. , Linde Amy Morgan , Grasseschi Mitchell F. , Wood Robert J. , Lacey Martin S. , Fang Xiangming 
Published: September 2020

Objective: To identify quantitative and qualitative differences in the velopharyngeal musculature and surrounding structures between children with submucous cleft palate (SMCP) and velopharyngeal insufficiency (VPI) and noncleft controls with normal anatomy and normal speech. Methods: Magnetic resonance imaging was used to evaluate the velopharyngeal mechanism in 20 children between 4 and 9 years of age; 5 with unrepaired SMCP and VPI. Quantitative and qualitative measures of the velum and levator veli palatini in participants with symptomatic SMCP were compared to noncleft controls with normal velopharyngeal anatomy and normal speech. Results: Analysis of covariance revealed that children with symptomatic SMCP demonstrated increased velar genu angle (15.6°, P = .004), decreased α angle (13.2°, P = .37), and longer (5.1 mm, P = .32) and thinner (4 mm, P = .005) levator veli palatini muscles compared to noncleft controls. Qualitative comparisons revealed discontinuity of the levator muscle through the velar midline and absence of a musculus uvulae in children with symptomatic SMCP compared to noncleft controls. Conclusions: The levator veli palatini muscle is longer, thinner, and discontinuous through the velar midline, and the musculus uvulae is absent in children with SMCP and VPI compared to noncleft controls. The overall velar configuration in children with SMCP and VPI is disadvantageous for achieving adequate velopharyngeal closure necessary for nonnasal speech compared to noncleft controls. These findings add to the body of literature documenting levator muscle, musculus uvulae, and velar and craniometric parameters in children with SMCP.