bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of the patient assessment of chronic illness care (PACIC) short form scale in heart transplant recipients: the international cross-sectional bright study
Authors:   on behalf of the BRIGHT study team, Iglesias Katia , De Geest Sabina , Berben Lut , Dobbels Fabienne , Denhaerynk Kris , Russell L. Cynthia , Helmy Remon , Peytremann-Bridevaux Isabelle 
Published: March 2020

AbstractBackgroundTransplant recipients are chronically ill patients, who require lifelong follow-up to manage co-morbidities and prevent graft loss. This necessitates a system of care that is congruent with the Chronic Care Model. The eleven-item self-report Patient Assessment of Chronic Illness Care (PACIC) scale assesses whether chronic care is congruent with the Chronic Care Model, yet its validity for heart transplant patients has not been tested.MethodsWe tested the validity of the English version of the PACIC, and compared the similarity of the internal structure of the PACIC across English-speaking countries (USA, Canada, Australia and United Kingdom) and across six languages (French, German, Dutch, Spanish, Italian and Portuguese). This was done using data from the cross-sectional international BRIGHT study that included 1378 heart transplant patients from eleven countries across 4 continents. To test the validity of the instrument, confirmatory factor analyses to check the expected unidimensional internal structure, and relations to other variables, were performed.ResultsMain analyses confirmed the validity of the English PACIC version for heart transplant patients. Exploratory analyses across English-speaking countries and languages also confirmed the single factorial dimension, except in Italian and Spanish.ConclusionThis scale could help healthcare providers monitor level of chronic illness management and improve transplantation care.Trial registrationClinicaltrials.gov ID:NCT01608477, first patient enrolled in March 2012, registered retrospectively: May 30, 2012.
Functional somatic disorders: discussion paper for a new common classification for research and clinical use
Authors:   on behalf of the EURONET-SOMA Group, Burton Christopher , Fink Per , Henningsen Peter , Löwe Bernd , Rief Winfried 
Published: March 2020

Abstract
Background
Functional somatic symptoms and disorders are common and complex phenomena involving both bodily and brain processes. They pose major challenges across medical specialties. These disorders are common and have significant impacts on patients’ quality of life and healthcare costs.

Main body
We outline five problems pointing to the need for a new classification: (1) developments in understanding aetiological mechanisms; (2) the current division of disorders according to the treating specialist; (3) failure of current classifications to cover the variety of disorders and their severity (for example, patients with symptoms from multiple organs systems); (4) the need to find acceptable categories and labels for patients that promote therapeutic partnership; and (5) the need to develop clinical services and research for people with severe disorders.
We propose ‘functional somatic disorders’ (FSD) as an umbrella term for various conditions characterised by persistent and troublesome physical symptoms. FSDs are diagnosed clinically, on the basis of characteristic symptom patterns. As with all diagnoses, a diagnosis of FSD should be made after considering other possible somatic and mental differential diagnoses. We propose that FSD should occupy a neutral space within disease classifications, favouring neither somatic disease aetiology, nor mental disorder. FSD should be subclassified as (a) multisystem, (b) single system, or (c) single symptom. While additional specifiers may be added to take account of psychological features or co-occurring diseases, neither of these is sufficient or necessary to make the diagnosis. We recommend that FSD criteria are written so as to harmonise with existing syndrome diagnoses. Where currently defined syndromes fall within the FSD spectrum – and also within organ system-specific chapters of a classification – they should be afforded dual parentage (for example, irritable bowel syndrome can belong to both gastrointestinal disorders and FSD).

Conclusion
We propose a new classification, ‘functional somatic disorder’, which is neither purely somatic nor purely mental, but occupies a neutral space between these two historical poles. This classification reflects both emerging aetiological evidence of the complex interactions between brain and body and the need to resolve the historical split between somatic and mental disorders.
Impact of seasonal malaria chemoprevention on hospital admissions and mortality in children under 5 years of age in Ouelessebougou, Mali
Authors: Issiaka Djibrilla , Barry Amadou , Traore Tiangoua , Diarra Boubacar , Cook David , Keita Mohamed , Sagara Issaka , Duffy Patrick , Fried Michal , Dicko Alassane 
Published: March 2020

Abstract
Background
Seasonal malaria chemoprevention is widely implemented in Sahel and sub-Sahel countries in Africa. Few studies have assessed the impact of the SMC on hospital admission and death when it is implemented in the health system. This retrospective study assessed the impact of seasonal malaria chemoprevention (SMC) on hospitalizations and deaths of children under 5 years of age during the second year of implementation of SMC in the health district of Ouelessebougou in Mali.

Methods
In February 2017, a survey was conducted to assess hospital admissions and deaths in children under 5 years of age in two health sub-districts where SMC was implemented in 2015 and two health sub-districts where SMC was not implemented. The survey reviewed deaths and hospitalizations of children under 5, in the four health sub-districts. The crude and specific incidence rates of hospitalizations and deaths were determined in both groups and expressed per 1000 children per year. A negative binomial regression model and a Cox model were used to estimate the relative risks of hospitalization and death after adjusting for confounders. The R software was used for data analysis.

Results
A total of 6638 children under 5 years of age were surveyed, 2759 children in the SMC intervention areas and 3879 children in the control areas. All causes mortality rate per 1000 person-years was 8.29 in the control areas compared to 3.63 in the intervention areas; age and gender adjusted mortality rate ratio 0.44 (95% CI 0.22–0.91), p = 0.027. The incidence rate of all causes hospital admissions was 19.60 per 1000 person-years in the intervention group compared to 33.45 per 1000 person-years in the control group, giving an incidence rate ratio (IRR) adjusted for age and gender of 0.61 (95% CI 0.44–0.84), p = 0.003.

Conclusion
The implementation of SMC was associated with a substantial reduction in hospital admissions and all-cause mortality.
Trial registration ClinicalTrials.gov NCT02646410.
miR-544 promotes maturity and antioxidation of stem cell-derived endothelial like cells by regulating the YY1/TET2 signalling axis
Authors: Guo Jianming , Xiang Qiuling , Xin Yaojie , Huang Yongyi , Zou Gang , Liu Te 
Published: March 2020

Abstract
Background
Inflammation and oxidative stress induced by oxidized low density lipoprotein are the main causes of vascular endothelial injury and atherosclerosis. Endothelial cells are important for the formation and repair of blood vessels. However, the detailed mechanism underlying the regulation of maturity and antioxidation of stem cell-derived endothelial like cells remains unclear. Besides, YY1 and TET2 play a key role on epigenetic modifications of proliferation and differentiation of stem cells. However, the regulatory mechanism of epigenetic modification induced by YY1 and TET2 on stem cells to iECICs is also not clear.

Aim
Here, we want to investigate detailed mechanism underlying the regulation of maturity and antioxidation of stem cell-derived iECICs by by YY1 and TET2.

Methods
The qPCR, Western blot, immunohistochemical staining and flow cytometric analysis were used to analyze the expression level of each gene. Luciferase reporter assay was used to detect the binding sites between microRNA and target genes. The hMeDIP-sequence, ChIP-PCR and dot blot were used to detect the 5-hydroxymethylcytosine modification of genomic DNA. ATP, ROS, SOD assay were used to evaluate of oxidative stress in cells. The iECICs transplantation group The ApoE−/− mice were intravenous injected of iECICs to evaluation of therapeutic effect in vivo.

Results
Our studies have found that as the differentiation of human amniotic epithelial cells (HuAECs) is directed towards iECICs in vitro, the expression levels of vascular endothelial cell markers and miR-544 increase significantly and the expression level of YinYang 1 (YY1) decreases significantly. The luciferase reporter assay suggests that Yy1 is one of the targets of miR-544. Hydroxymethylated DNA immunoprecipitation sequencing showed that compared with HuAECs, iECICs had 174 protein-coding DNA sequences with extensive hydroxymethylation modifications. Overexpression of miR-544 inhibits the activity of the YY1/PRC2 complex and promotes the transcription and expression of the ten-eleven translocation 2 (TET2) gene, thereby activating the key factors of the serotonergic synapse pathway, CACNA1F, and CYP2D6. In addition, it promotes ability of maturity, antioxidation and vascular formation in vitro. Meanwhile, transplantation for miR-544-iECICs can significantly relieve oxidative stress injury on ApoE−/− atherosclerotic mice in vivo.

Conclusions
miR-544 regulates the maturity and antioxidation of iECICs derived from HuAECs by regulating the YY1/TET2/serotonergic synapse signalling axis.
Fabrication of Ag nanoparticles adhered on RGO based on both electrodes in dye-sensitized solar cells (DSSCs)
Authors: Pattarith Kongsak , Areerob Yonrapach 
Published: March 2020

AbstractThe electrode plays an important role in dye-sensitized solar cells (DSSCs). Preparation of the electrode should be simple and should result in high performance of its DSSC. We herein demonstrated high-performance and easily prepared Silver nanoparticles adhered on Reduced graphene oxide–Platinum composites (Ag–RGO/Pt) as counter electrodes (CEs) and TiO2 on RGO sheets with Ag (TiO2–RGO/Ag) as photoanode (PE) in DSSCs. The 1:2 Ag–RGO/Pt CE and 0.5% TiO2–RGO/Ag PE showed an overall highest power conversion efficiency of 9.15% under (1.5 AM) solar irradiation. The optimal weight ratio of Ag:RGO:Pt materials was also examined. Moreover, we showed that incorporation of Ag nanoparticles into the counter electrode successfully improved interfacial charge transfer resulting in high electrocatalytic activity for the reduction of triiodide to iodide redox, which in turn could enhance the performance of the DSSCs.
Low-Dose Abiraterone in Metastatic Prostate Cancer: Is It Practice Changing? Facts and Facets
Authors: Patel Amol , Tannock Ian F. , Srivastava Priyanka , Biswas Bivas , Gupta Vineet Govinda , Batra Atul , Bhethanabhotla Sainath , Pramanik Raja , Mahindru Shubh , Tilak TVSVGK , Das Chandan Krishna , Mehta Prashant 
Published: March 2020

PURPOSEIt is projected that approximately 50,000 new cases of prostate cancer will be diagnosed in 2020 in India. Survival has improved because of the development of effective drugs such as abiraterone acetate, but universal accessibility to treatment is not always possible because of cost constraints in lower- and middle-income countries. Recently, the National Comprehensive Cancer Network (NCCN) has included low-dose abiraterone (250 mg/day) with food as an alternative treatment option to full-dose abiraterone (1,000 mg/day) fasting.METHODSThe Science and Cost Cancer Consortium conducted a survey to evaluate the use of abiraterone in India and the opinions of medical oncologists about using low-dose treatment. Modeling was used to estimate potential financial benefits to individual patients and to estimate overall costs of health care in India if low-dose abiraterone is prescribed.RESULTSOf 251 Indian medical oncologists who were invited to participate in the survey, 125 provided their e-mail address and received the survey; 118 responded (47% of the total). Of these, 25% were not aware of the recent NCCN recommendation, 55% were already prescribing low-dose abiraterone when resources were limited, 7% had already changed their practice, and 29% agreed to switch to a universal practice of using low-dose abiraterone with food; 9% of practitioners would not use low-dose abiraterone. Estimated mean per patient savings was US$3,640, with annual savings of US$182 million in India.CONCLUSIONUse of lower-dose abiraterone would increase access to treatment in India and globally and lead to large cost savings.
Whale jaw joint is a shock absorber
Authors: Werth Alexander J. , Ito Haruka 
Published: March 2020

ABSTRACT
The non-synovial temporomandibular jaw joint of rorqual whales is presumed to withstand intense stresses when huge volumes of water are engulfed during lunge feeding. Examination and manipulation of temporomandibular joints (TMJs) in fresh carcasses, plus CT scans and field/lab mechanical testing of excised tissue blocks, reveals that the TMJ's fibrocartilage pad fully and quickly rebounds after shrinking by 68–88% in compression (by axis) and stretching 176–230%. It is more extensible along the mediolateral axis and less extensible dorsoventrally, but mostly isotropic, with collagen and elastin fibers running in all directions. The rorqual TMJ pad compresses as gape increases. Its stiffness is hypothesized to damp acceleration, whereas its elasticity is hypothesized to absorb shock during engulfment, allow for rotation or other jaw motion during gape opening/closure, and aid in returning jaws to their closed position during filtration via elastic recoil with conversion of stored potential energy into kinetic energy.
Minimum-Volume Covering Ellipsoids: Improving the Efficiency of the Wolfe-Atwood Algorithm for Large-Scale Instances by Pooling and Batching
Authors: Kudela Jakub 
Published: March 2020

The Minimum-Volume Covering Ellipsoid (MVCE) problem is an important optimization problem that comes up in various areas of engineering and statistics. In this paper, we improve the state-of-the-art Wolfe-Atwood algorithm for solving the MVCE problem with pooling and batching procedures. This implementation yields significant improvements on the runtime of the algorithm for large-scale instances of the MVCE problem, which is demonstrated on quite extensive computational experiments.
Design of an amplitude-splitting hard x-ray delay line with subnanoradian stability
Authors: Li Haoyuan , Sun Yanwen , Sutton Mark , Fuoss Paul , Zhu Diling 
Published: March 2020

We present the design and analysis of a hard x-ray split-delay optical arrangement that combines diffractive and crystal optics. Transmission gratings are employed to achieve the much-desired amplitude splitting and recombination of the beam. Asymmetric channel-cut crystals are utilized to tune the relative delay time. The use of a dispersion-compensation arrangement of the crystals allows the system to achieve subnanoradian pointing stability during a delay scan. It also minimizes wavefront distortion and preserves the pulse front and pulse duration. We analyze the performance of a prototype design that can cover a delay time range of 15 ps with a sub-20 fs time resolution at 10 keV. We anticipate that this system can fully satisfy the very demanding stability requirements for performing split-pulse x-ray photon correlation spectroscopy measurements for the investigation of fast atomic scale dynamics in complex disordered matter.
GRAPHITE FURNACE ATOMIC ABSORPTION SPECTROPHOTOMETRY SEBAGAI METODE ANALISIS LOGAM BERAT
Authors: Budiyanto Fitri 
Published: March 2020

GRAPHITE FURNACE ATOMIC ABSORPTION SPECTROPHOTOMETRY AS A METHOD FOR ANALYZING HEAVY METAL. Heavy metal, mostly present in a (ultra) trace-level, becomes one of the hazardous pollutants due to its toxicity, bioaccumulative, biomagnification characters. Conducting a micro analysis of these trace-level pollutants, a sensitive instrument and method are strongly recommended. Graphite Furnace Atomic Absorption Spectrophotometer (GFAAS) offers a solution for the challenge. It uses the principle of light emission absorption by nascent atom cloud from the metals. The analysis has been developed in three stages of the tube heating programs, i.e. drying, ashing and then atomizing element at 3000° C. Since the injected sample is almost completely atomized, the sensitivity of GFAAS is extremely high and this value is covering up the disadvantages of the other analyses. Therefore, the GFAAS analysis is suitable fo ultra-trace analysis of ultra-trace pollutants like heavy metals in environment.
KARAKTERISTIK DAN DAMPAK MAKROALGA INTRODUKSI
Authors: Handayani Tri 
Published: March 2020

CHARACTERISTIC AND IMPACTS OF INTRODUCED MACROALGAE. An introduced macroalgae is species of macroalgae that have been introduced beyond its native range through human activities and has become successfully established in the new locale. Introduced macroalgae have an impact on ecology and evolution, i.e. direct and indirect competitions with native biota (space monopolization and change in community composition), effects on higher trophic levels (herbivores, associated fauna, toxicity), habitat change (changed structure, sediment accumulation), change of ecosystem processes (alteration of trophic structure) and genetic effects. Introduced macroalgae also have an impact on economy and social, i.e. costs of loss of ecosystem functions or values, impacts on environmental amenity, impacts on human health, management costs (government/non-government), costs of research into introduced species, costs for eradication and control measures and costs for education/extension campaigns. Management of impact and research are needed to minimize the impact of introduced macroalgae.
Reconstruction of Thumb Polydactily: A Case Report
Authors: Budiman Budiman , Utami Gladya , Nazwan Sani T. Fadli 
Published: March 2020

Background: Polydactyly is the most common hand congenital abnormality found, next after syndactyly. The presence of these extra fingers is not merely duplication but is accompanied by abnormal hypoplastic structures, abnormal joints, tendon anomalies, and anomly of the insertion of ligaments. There are many tehniques proposed to reconstruct polydactyly, from simple excision of bones, ligaments, and tendons to complex reconstructions. We report a case of polydactily, the patient had bone exicision of the duplicates when the patient was four-month-old, but that extra metacarpal with no phalanges resulted in a greater space of finger 1 and 2.
Patient and Method: A 21-year-old woman complaining of difficulty in grasping because the space between first and second fingers is too far away, and the extra metacarpal bone is protruding that causes snagging and stumbling on other objects. She had a history of surgical removal of polydactyl when she was 4-month-old. The patient has a limitation in hand activities.
Result: Six months after surgery, the patient was satisfied with the results. The fingers has better mobility, good appearance. No more prominent bone, and neuropathic problems, or other disorders were found.
Conclusion: Polydactyly is a common congenital hand occurrence. Understanding the anatomy to guide the reconstructive actions is important. It is not only about which digit would be preserved, but we have to concern about what our patient need, improving the quality, patient's hand function, and the aesthetic aspect.
Drawing a Structural Model by the Most Effective Components on Optimal Global Marketing
Authors: Nazari Farzad , Najafi Soodabeh , Shahsavari Farnaz , Zeynalzadeh Aylar 
Published: March 2020

Goal: International trade and success in this field is one of the most important goals based on the profitability and reputation among different companies and organizations, in which the most important tool is optimal global and international marketing; therefore, this research aims at drawing the model of structure by the components influencing optimal global marketing.
Design / Methodology / Approach: To this end, 385 experts, professionals, and scholars in this field, whose number was determined by the Cochran formula, completed a researcher-made questionnaire. In this paper used the structural equation method.
Results: The results show that the application of technology, product quality, price, variety and communication (brand) are the five affecting factors on optimal global marketing. In the meantime, the product quality has the greatest effect on optimal global marketing, and with exception of the diversity which is the indirect predictor of optimal global marketing, other variables directly predict this indicator, as well as the results of fitting the model showed that the created model is an efficient and reliable tool for investigating the components affecting the identification of global optimal marketing.
Practical implications: results of this study can be use to increase sales and supply rates of products Because by knowing the best marketing agents can increased the rate of supply of goods and products.
Research limitations: This research has been done in Iran, Naturally, it has to be validated for use elsewhere in the world, it is possible that it may not be cited elsewhere or give different results.
Originality / Value: It has not been studied so far and the results of this article can be used all over the world.
Die Erkennung unangemessener Inhalte im Internet: KI-Verfahren, Evaluierung und Herausforderungen
Authors: Mandl Thomas 
Published: March 2020

Abstract
In sozialen Medien finden sich sehr oft aggressive und hasserfüllte Posts. Deren automatische Erkennung ist wünschenswert und wird derzeit intensiv erforscht. Die Qualität der entsprechenden Algorithmen muss laufend bewertet werden. Der Artikel berichtet von Evaluierungsergebnissen und den Herausforderungen im Rahmen der HASOC Initiative 2019. Davor werden die neuronale Netzwerk-Architekturen wie beispielsweise BERT eingeführt, die derzeit die besten Ergebnisse liefern.