bluuebunny/crossref_metadata_2025_split huggingface dataset:
ОСОБЛИВОСТІ РОБОТИ МЕДИЧНИХ СЕСТЕР У ЗОНІ БОЙОВИХ ДІЙ
Authors: Tzipkalo A. I. , Marushchak M. I. , Krynytska I. Ya. 
Published: June 2020

Забезпечення кожному постраждалому належної медичної допомоги збільшує шанси на виживання та відновлення функцій протягом усього процесу надання медичної допомоги, що зумовлює актуальність аналізу складнощів у виконанні покладених на медсестер обов’язків у зоні бойових дій.
Мета дослідження – проаналізувати особливості роботи медичних сестер у зоні ведення бойових дій та на їх основі сформулювати рекомендації щодо удосконалення освітніх навчальних програм для медсестер.
Матеріали і методи. На базі військово-медичної служби ВМС УСБУ в Закарпатській області було про­аналізовано анкетні дані медичних сестер, які проходили військову службу в зоні антитерористичної операції упродовж 2015–2017 рр. Основним запитанням до респондентів було коротко описати складнощі у виконанні покладених на медсестер обов’язків.
Результати. Аналізуючи отримані відповіді медичних сестер, які виконували свої професійні обов’язки в зоні бойових дій, було сформульовано основні складнощі їх роботи в умовах прямої і непрямої загрози: недостатні знання принципів Tactical Combat Casualty Care; розподіл поранених при евакуації в умовах тактичної екстреної медичної допомоги; різна популяція постраждалих, яка включала не тільки військовослужбовців, а й мирне населення, у тому числі педіатричні й геріатричні вікові групи; необхідність психологічної допомоги військово­службовцям і мирному населенню в зоні бойових дій; недостатній досвід тактичної евакуації.
Висновки. Для оптимізації професійних знань медичних сестер у цих напрямках рекомендується включити освітні компоненти «Тактична медицина» і «Екстрена психологічна допомога» в освітні навчальні програми для медсестер.
КЛІНІЧНИЙ ВИПАДОК БОРЕЛІОЗНОЇ ІНФЕКЦІЇ ЯК МОЖЛИВОЇ ПРИЧИНИ УРАЖЕННЯ СЕРЦЯ ТА ВИНИКНЕННЯ СИНКОПАЛЬНИХ СТАНІВ
Authors: Dzyha S. V. , Bakalets O. V. , Behosh N. B. , Maksiv K. Y. 
Published: June 2020

Прояви ураження серця при лайм-бореліозі варіюють від безсимптомних чи симптомних електрокардіографічних (ЕКГ) змін та блокад серця, зворотних при лікуванні, до раптової смерті. Синдром слабкості синусового вузла як прояв лайм-кардиту зустрічається рідко.
Мета дослідження – описати випадок виникнення синкопальних станів унаслідок дисфункції синусового вузла в пацієнтки з лайм-бореліозом.
Матеріали і методи. Пацієнтку, яка перебувала на стаціонарному лікуванні у кардіологічному відділенні Тернопільської університетської лікарні, обстежено згідно з протоколом для оцінки стану серцево-судинної системи. Холтерівське моніторування проводили з використанням електрокардіографічного комплексу ECG-pro (ІМЕСК).
Результати. Пацієнтку турбували епізоди втрати свідомості, виражена загальна слабість. За допомогою серодіагностики виявили специфічні антитіла до Borrelia afzelii в кількості, що підверджує наявність інфекції. При добовому моніторуванні ЕКГ зафіксовано наявність синусової паузи тривалістю 16 с, що виникла у ранковий час.
Висновки. Діагностовано симптомну дисфункцію синусового вузла як прояв лайм-кардиту, що потре­бува­ло встановлення постійного кардіостимулятора.
COP9 Signalosome Suppresses RIPK1-RIPK3–Mediated Cardiomyocyte Necroptosis in Mice
Authors: Xiao Peng , Wang Changhua , Li Jie , Su Huabo , Yang Liuqing , Wu Penglong , Lewno Megan T. , Liu Jinbao , Wang Xuejun 
Published: June 2020

Background:

Mechanisms governing the induction of heart failure by the impairment of autophagy and the ubiquitin-proteasome system and the molecular pathways to cardiomyocyte necrosis remain incompletely understood. COPS8 is an essential subunit of the COP9 (COnstitutive Photomorphogenesis 9) signalosome, a key regulator of ubiquitination. Mice with cardiomyocyte-restricted knockout of
Cops8
(Cops8-cko) show autophagic and ubiquitin-proteasome system malfunction and massive cardiomyocyte necrosis followed by acute heart failure and premature death, providing an excellent animal model to address the mechanistic gaps specified above. This study was conducted to determine the nature and underlying mechanisms of the cardiomyocyte necrosis in Cops8-cko mice.

Methods and Results:

Compared with littermate control mice, myocardial protein levels of key factors in the necroptotic pathway (RIPK1 [receptor-interacting protein kinase 1], RIPK3, MLKL [mixed lineage kinase-like], the RIPK1-bound RIPK3), protein carbonyls, full-length Casp8 (caspase 8), and BCL2, as well as histochemical staining of superoxide anions were significantly higher but the cleaved Casp8 and the Casp8 activity were significantly lower in Cops8-cko mice. In vivo cardiomyocyte uptake of Evan’s blue dye was used as an indicator of necrosis. Cops8-cko mice treated with a RIPK1 kinase inhibitor (Nec-1 [Necrostatin-1]) showed less Evans blue dye uptake (0.005% versus 0.20%;
P
<0.0001) and longer median lifespan (32.5 versus 27 days;
P
<0.01) than those treated with vehicle control.
RIPK3
haploinsufficiency showed similar rescuing effects on Cops8-cko but Cyclophilin D deficiency did the opposite.

Conclusions:
Cardiac Cops8/COP9 signalosome malfunction causes RIPK1-RIPK3 dependent, but mitochondrial permeability transition pore independent, cardiomyocyte necroptosis in mice and the COP9 signalosome plays an indispensable role in suppressing cardiomyocyte necroptosis.
Prognostic Value of Functional Capacity in Different Exercise Protocols
Authors: Harb Serge C. , Bhat Pavan , Cremer Paul C. , Wu Yuping , Cremer Laura J. , Berger Stephanie , Cho Leslie , Menon Venu , Gulati Martha , Jaber Wael A. 
Published: June 2020

Background
Functional capacity is associated with mortality, although the prognostic value of achieved estimated metabolic equivalents (METs) across various exercise protocols is not established. We sought to determine whether achieved METs had different prognostic implications according to the protocol employed.

Methods and Results
From 1991 to 2015, we identified 120 705 consecutive patients from a stress testing registry who underwent the following 7 different standardized exercise protocols: Bruce, modified Bruce, Cornell 0%, Cornell 5%, Cornell 10%, Naughton, and modified Naughton. The primary outcome was all‐cause mortality. There were 74 953 Bruce, 8368 modified Bruce, 2648 Cornell 0%, 9972 Cornell 5%, 20 425 Cornell 10%, 1226 Naughton, and 3113 modified Naughton protocols. During a mean follow‐up of 8.7 years, a total of 8426 deaths (6.9%) occurred. When compared with the Bruce protocol, after multivariable adjustment for clinical risk factors, medications, and functional capacity, test protocol was independently associated with mortality (modified Naughton [hazard ratio (HR), 2.51; 95% CI, 2.26–2.8], Naughton [HR, 1.79; 95% CI, 1.57–2.04], Cornell 0% [HR, 1.79; 95% CI, 1.59–2.01], modified Bruce [HR, 1.62; 95% CI, 1.48–1.76], Cornell 5% [HR, 1.61; 95% CI, 1.47–1.75], and Cornell 10% [HR, 1.32; 95% CI, 1.22–1.42]). Across all protocols, higher estimated METs were associated with lower mortality, although the equivalent METs achieved were associated with a worse prognosis in less‐demanding protocols.

Conclusions
Higher estimated METs are reliably associated with lower mortality in all exercise protocols, although the prognostic value is not transferable across different tests. Consequently, the prognostic value of METs achieved during a stress test should be considered protocol dependent.
Extracorporeal Life Support in Pregnancy: A Systematic Review
Authors: Naoum Emily E. , Chalupka Andrew , Haft Jonathan , MacEachern Mark , Vandeven Cosmas J. M. , Easter Sarah Rae , Maile Michael , Bateman Brian T. , Bauer Melissa E. 
Published: June 2020

BackgroundThe use of extracorporeal life support (ECLS) has expanded to include unique populations such as peripartum women. This systematic review aims to (1) quantify the number of cases and indications forECLSin women during the peripartum period reported in the literature and (2) report maternal and fetal complications and outcomes associated with peripartumECLS.Methods and ResultsThis review was registered inPROSPERO(CRD42018108142).MEDLINE, Embase, andCINAHLwere searched for case reports, case series, and studies reporting cases ofECLSduring the peripartum period that reported one or more of the following outcomes: maternal survival, maternal complications, fetal survival, and/or fetal complications. Qualitative assessment of 221 publications evaluated the number of cases, clinical details, and maternal and fetal outcomes ofECLSduring the peripartum period. There were 358 women included and 68 reported fetal outcomes in cases where the mother was pregnant at the time of cannulation. The aggregate maternal survival at 30 days was 270 (75.4%) and at 1 year was 266 (74.3%); fetal survival was 44 (64.7%). The most common indications forECLSoverall in pregnancy included acute respiratory distress syndrome 177 (49.4%), cardiac failure 67 (18.7%), and cardiac arrest 57 (15.9%). The most common maternal complications included mild to moderate bleeding 66 (18.4%), severe bleeding requiring surgical intervention 48 (13.4%), and intracranial neurologic morbidity 19 (5.3%). The most commonly reported fetal complications included preterm delivery 33 (48.5%) and neonatal intensive care unit admission 19 (27.9%).ConclusionsReported rates of survival inECLSin pregnant and postpartum women are high and major complications relatively low.
Additional Low‐Voltage‐Area Ablation in Patients With Paroxysmal Atrial Fibrillation: Results of the Randomized Controlled VOLCANO Trial
Authors: Masuda Masaharu , Asai Mitsutoshi , Iida Osamu , Okamoto Shin , Ishihara Takayuki , Nanto Kiyonori , Kanda Takashi , Tsujimura Takuya , Matsuda Yasuhiro , Okuno Shota , Hata Yosuke , Mano Toshiaki 
Published: June 2020

Background

The efficacy of low‐voltage‐area (
LVA
) ablation has not been well determined. This study aimed to investigate the efficacy of
LVA
ablation in addition to pulmonary vein isolation on rhythm outcomes in patients with paroxysmal atrial fibrillation (
AF
).

Methods and Results

VOLCANO (Catheter Ablation Targeting Low‐Voltage Areas After Pulmonary Vein Isolation in Paroxysmal Atrial Fibrillation Patients) trial included paroxysmal AF patients undergoing initial AF ablation. Of 398 patients in whom a left atrial voltage map was obtained after pulmonary vein isolation, 336 (85%) had no
LVA
(group A). The remaining 62 (15%) patients with
LVA
s were randomly allocated to undergo
LVA
ablation (group B, n=30) or not (group C, n=32) in a 1:1 fashion. Primary end point was 1‐year
AF
‐recurrence‐free survival rate. No adverse events related to
LVA
ablation occurred. Procedural (124±40 versus 95±33 minutes,
P
=0.003) and fluoroscopic times (29±11 versus 24±8 minutes,
P
=0.034) were longer in group B than group C. Patients with
LVA
s demonstrated lower
AF
‐recurrence‐free survival rates (88%) than those without
LVA
(B, 57%,
P
<0.0001; C, 53%,
P
<0.0001). However,
LVA
ablation in addition to pulmonary vein isolation did not impact
AF
‐recurrence‐free survival rate (group B versus C,
P
=0.67).

Conclusions

The presence of
LVA
was a strong predictor of
AF
recurrence after pulmonary vein isolation in patients with paroxysmal
AF
. However,
LVA
ablation had no beneficial impact on 1‐year rhythm outcomes.

Registration

URL:
https://www.umin.ac.jp/ctr
; Unique identifier: UMIN000023403.
Credibility and Testimony in Asylum Procedures with Unaccompanied Refugee Minors
Authors: Guarch-Rubio Marta , Manzanero Antonio L. 
Published: June 2020

Abstract
The present article reviews the credibility analysis procedure proposed by the UNHCR through which asylum applications are resolved, especially for unaccompanied minors. The particularities of these refugee minors and the general character of the credibility analysis procedure are described. Credibility indicators are analyzed together with the psychological barriers related to them. This manuscript provides evidence of the presence of trauma and resilience in the studied minors and how both influence their memories during the asylum interviews. As credibility assessment has a special focus on the evaluation of narratives through memory, memory is considered as a criterion responsible for the accuracy and credibility of underage applicants’ testimony. Finally, this paper contributes with scientific psychological evidence towards the existence of multiple testimonies in asylum seekers.
The Holy See’s Position on Lethal Autonomous Weapons Systems
Authors: Mauri Diego 
Published: June 2020

The issue of lethal autonomous weapons systems (laws) goes to the heart of the debate on new warfare technologies: States, international organizations, non-governmental organizations and civil society at large have long been discussing the acceptability of ‘autonomous killing’. The present contribution zooms in on the position held by the Holy See, exploring its content and the main arguments which support the call of a ban on such technology. Both diplomatic statements and doctrinal teachings will be tackled. Importantly, a solid argument for a prohibition of laws is based on the moral unacceptability of autonomous killing, which may assume also a legal standing through the so-called Martens Clause. The history and the actual content of the Clause will be analyzed in order to explore whether – and to what extent – it can be interpreted so as to offer a legal ground for rejecting laws. It will be argued that the Holy See is in a particularly fit position to advocate for a renewed appraisal of the Martens Clause that may help the pro-ban front to structure a more principled debate.
Composite Cartilage-osseous-mucosal Nasoseptal Flap for Reconstruction after Near Total Rhinectomy
Authors: Shastri Karthik S. , Lin Yufan , Scordino Jessica , Pinheiro-Neto Carlos D. 
Published: June 2020

Background: Reconstruction of full thickness nasal defects usually requires different donor sites for the external skin envelope, structural elements, and internal nasal lining. In this paper we present a novel single site method for dual inner lining and skeleton repair for full thickness nasal defects with a composite nasoseptal flap and extended pedicle dissection. Methods: A 72-year-old male presented with a T4b melanoma involving the nasal dorsum and left upper lateral cartilage. Following full thickness resection, reconstruction was performed with a nasoseptal flap (NSF) with attached septal cartilage and vomer in conjunction with a paramedian forehead flap. Extended pedicle dissection into the pterygopalatine fossa allowed the NSF to fully cover the defect. Results: The nasal defect was fully corrected. There was no evidence of flap compromise or nasal valve stenosis at 1 month, 2 month, and 1 year follow-up visits. Conclusions: We present here the first successful application of a composite cartilage-osseous-mucosal NSF for multilayered nasal reconstruction. In appropriate patients, this technique may obviate the need for flaps or grafts from extranasal sources, limiting donor site morbidity.
Is suicidal behaviour a stronger predictor of later suicide than suicidal ideation? A systematic review and meta-analysis
Authors: Large Matthew , Corderoy Amy , McHugh Catherine 
Published: June 2020

Objective: Suicidal ideation and suicidal behaviour are both regarded as important risk factors for suicide, but it is usually believed that suicidal ideation is less strongly linked to suicide than suicidal behaviours. In this study, we assessed and compared the strengths of the associations that suicidal ideation and suicidal behaviour have with later suicide using meta-analysis of primary studies reporting both these independent variables and the dependent variable of suicide. Methods: A total of 51 English language publications describing cohort or controlled studies that reported on both the association between suicidal ideation and suicide and the association between suicidal behaviours and suicide were located using searches for titles in PubMed containing variants of the word suicide (suicid*). Suicides were considered to include reported suicides and open verdicts from mortality registers. The strengths of the two associations were examined in separate random effects meta-analyses and were then compared using mixed effects meta-regression. Subgroups were examined according to study characteristics including the definitions of suicidal ideation or behaviour used, setting (psychiatric or non-psychiatric), diagnostic mix of the study population, study design (cohort or control) and study quality. Results: Suicidal ideation (odds ratio = 3.11, 95% confidence interval = 2.51, 3.86) and suicidal behaviours (odds ratio = 4.09, 95% confidence interval = 3.05, 5.49) were both significantly associated with suicide but there was no significant difference in the strengths of association ( p = 0.14). Nor were there significant differences in the strengths of the two associations in multiple subgroup analyses. Conclusion: Suicidal ideation and suicidal behaviour are both moderately associated with suicide. Existing data cannot conclusively demonstrate that suicidal behaviours are more strongly associated with suicide than suicidal ideation. Clinicians should not strongly prioritise suicidal behaviour over suicidal ideation when considering suicide risk.
State Trends in HIV Testing Among US Adults Aged 18-64 Years, 2011-2017
Authors: Krueger Amy , Johnson Christopher , Heitgerd Janet , Patel Deesha , Harris Norma 
Published: June 2020

Objectives HIV testing identifies persons living with HIV and can lead to treatment, decreased risk behaviors, and reduced transmission. The objective of our study was to describe state-level trends in HIV testing in the general US adult population aged 18-64 years, for both ever tested for HIV and tested for HIV in the previous 12 months. Methods Using 2011-2017 Behavioral Risk Factor Surveillance System data, we estimated the percentage of the state population, plus the District of Columbia, aged 18-64 years ever tested for HIV and tested for HIV in the previous 12 months. The 50 states and the District of Columbia were grouped according to the estimated prevalence of HIV in 2011. We used orthogonal contrasts to calculate P values for linear trends. Results The percentage of the population ever tested for HIV increased significantly in 23 states during 2011-2017, whereas the percentage tested for HIV in the previous 12 months increased significantly in 8 states. In 2017, the mean percentage ever tested for HIV in states with a high prevalence of HIV was 8.6 percentage points higher than the mean percentage in states with a low prevalence of HIV (48.5% vs 39.9%); the mean increase in the percentage ever tested was highest (11.4%) in states with a low prevalence of HIV. Conclusion Enhanced efforts by states to make HIV testing simple, accessible, and routine are needed to reduce the number of persons who are not aware of their infection.
Anatomical and Functional Results of Medial and Lateral Surface of Temporal Muscle Fascia in Type 1 Tympanoplasties
Authors: Salcan İsmail 
Published: June 2020

Aim: The aim of this study is to investigate whether there is a difference in the anatomical success of the graft and the functional gain of hearing as a result of the medial or lateral surface application of the temporalis muscle fascia graft. Materials and Methods: Seventy-three patients who underwent tympanoplasty (myringoplasty) type 1 surgery due to tympanic membrane perforation between December 2017 and December 2019 were included in this study. The gender and age of the patients during this study were determined. Preoperative tympanic membrane perforation types were grouped as central, marginal subtotal, and total. Airway pure tone average threshold values were evaluated preoperatively at 500 Hz, 1000 Hz, 2000 Hz, and 4000 Hz. Findings: Seventy-three patients were included in the study. Medial surface of the temporalis muscle fascia was placed onto the manubrium mallei of the malleus with over-underlay method in group 1 (n = 37) and similarly, lateral surface of the temporalis muscle fascia was placed onto the manubrium mallei of the malleus with over-underlay method in group 2 (n = 36). After tympanoplasty, it was seen that 79.5% of the grafts were intact. Graft success was lower in total perforations than other types; 51.7% of the patients with intact graft were group 1, and there was no significant relationship between graft success and groups. As a result of the assessment made in terms of hearing gain, a statistically significant change was detected in the hearing in the postoperative sixth month compared to the preoperative period in both groups. Conclusion: In this study, we demonstrated that there is no difference in terms of the anatomical success of the graft and the functional gain of hearing with type 1 tympanoplasty surgery.
Most Cited Articles in Head and Neck Oncology
Authors: Enver Necati , Şahin Akın , Sönmez Said , Demokan Semra 
Published: June 2020

Objectives: The number of citations an article receives is an important indication of its impact. The main objectives of this investigation provide readers with a practical guide in evaluating head and neck oncology literature and determine the characteristics of trends in ORL. Methods: This was a retrospective bibliometric analysis that did not involve human participant. The Thomson Reuters Web of Science was searched to determine the citations of all published HNO articles. Most cited 300 article analyzed and a total of 100 articles were included in our investigation under the topic search “Head AND NECK AND (cancer OR carcinoma OR oncology).” Articles include malignancies other than head and neck are excluded. The top 100 cited articles were selected and analyzed by 2 independent investigators. Country, Institution, First Author, Journal name, study design, cites per year information gathered and analyzed. Results: The journal with the highest number of top 100 cited articles was New England Journal Of Medicine with 19 paper, followed by The Journal of Clinical Oncology(17) and Cancer Research (12). The top article on the list (Radiotherapy plus cetuximab for squamous cell carcinoma of the head and neck-NEJM) has 2243 citations. A statistically significant association was found between the journal impact factor and the number of top 100 cited articles ( P < .05). The United States had the highest number of articles (63). John Hopkins is differed from other institutions with 15 contributing articles. Conclusion: Our analysis provides an insight into the citation frequency of top cited articles published in HNO to help recognize the quality of the works, discoveries and the trends steering the study of HNO. This is also a modern reading list for young HNO scientist.