bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Prospective Review on Phyto-pharmacological Aspects of Vitex negundo Linn
Authors: Khan Mohd Faisal , Arora Poonam , Dhobi Mahaveer 
Published: November 2019

Background:
Vitex negundo Linn. commonly known as five leave chase tree is an
ethnobotanically important drug in traditional system of medicine. The plant is widely distributed
in India, China and other Asian and American countries.

Objective:
The review aims at presenting comprehensive information with respect to ethnopharmacological
relevance and recent findings on phytochemical and biological activities
of Vitex negundo.

Method:
Literature was collected from various sources such as pubmed, scopus, science direct,
and others.

Results:
Extracts and secondary metabolites of this plant, particularly those from roots and
leaves, possess useful pharmacological activities such as anti-inflammatory, antitumor, antioxidant,
antimicrobial, galactagogue, antigastric, antiflatulant, antiparasitic, analgesic, hepatoprotective
and antihypertensive, some of which have been validated scientifically. All parts
of the plant especially leave and roots contain a large number of bioactive phytoconstituents
including flavonoids, iridoids, lignans, volatile oil, terpenes, coumarins, phenolic and steroidal
compounds which impart multiple medicinal properties. Vitexin, isovitexin, viridifol,
caffeic acid, chlorogenic acid and isochlorogenic acid are the main components.

Conclusion:
The review emphasizes the medicinal importance of Vitex negundo and its bioactive
constituents in the traditional system of medicine.
PMLSM Nonlinear Integral Sliding Mode Control Based on Gain Time- Varying Reaching Law
Authors: Zhang Chao , Zhang Liwei , Peng Bo , Zhao He 
Published: November 2019

Background:
The permanent magnet synchronous linear motor is a strongly coupled,
nonlinear system. It has been applied in many fields, especially in the field of machining lathes and
rail transportation. In order to ensure the permanent magnet synchronous linear motor has good dynamic
performance and robustness, sliding mode control is gradually applied to the control system
of permanent magnet synchronous linear motor. However, in the traditional sliding mode control,
the convergence speed is slow, and the robust performance is poor when the sliding surface is not
reached.

Objective:
The main purpose of this paper is to improve the dynamic performance and robustness of
the permanent magnet synchronous linear motor during the process of approaching the sliding surface.

Methods:
Firstly, the type of nonlinear curve with "small error reduction, large error saturation" is
introduced to design a nonlinear integral speed controller with global robustness. Secondly, the gain
rate time-varying reaching law is introduced to reduce "chattering". Finally, using a symbolic tangent
function instead of a sign function in designing a sliding mode observer reduces fluctuations in
load observations.

Results:
Finally, the correctness and effectiveness of the control method are proved by simulation.

Conclusion:
The results of the simulation show that the nonlinear integral sliding mode controller
based on gain time-varying reaching law is shown to have good global robustness and dynamic performance.
Hazai Ipari Hulladékok Innovatív Hasznosítási Lehetőségei Építőanyagipari Célra
Authors: Mucsi Gábor , Szabó Roland , Rácz Ádám , Papné Halyag Nóra , Nagy Gáborné Ambrus Mária , Debreczeni Ákos , Móricz Ferenc , Kristály Ferenc 
Published: November 2019

A Miskolci Egyetem Műszaki Földtudományi Karán működő Fenntartható Természeti Erőforrás Gazdálkodás Kiválósági Központban elvégzett kutatások eredményei azt mutatják, hogy a megfelelő előkészítést alkalmazva és a körülményeket optimálva a hulladék alapanyagok eljárástechnikai jellemzőinek (szemcseméret eloszlás, fajlagos felület) megváltoztatásával az építőanyag termékek fizikai és mechanikai tulajdonságai (szilárdság, tömörség) javíthatók. Kutatásaink ugyanis kimutatták, hogy a kémiai aktiválás mellett a mechanikai aktiválás is egy igen hatékony eszköz a tulajdonságok szabályozására. Ez azonban megváltoztatja nemcsak a termék fizikai, mechanikai, hanem a szerkezeti, ásványtani jellemzőit is, ezért ezen jellemzők meghatározása is kiemelten fontos.
Internet Searches for Medical Symptoms Before Seeking Information on 12-Step Addiction Treatment Programs: A Web-Search Log Analysis
Authors: Nitzburg George , Weber Ingmar , Yom-Tov Elad 
Published: November 2019

BackgroundBrief intervention is a critical method for identifying patients with problematic substance use in primary care settings and for motivating them to consider treatment options. However, despite considerable evidence of delay discounting in patients with substance use disorders, most brief advice by physicians focuses on the long-term negative medical consequences, which may not be the best way to motivate patients to seek treatment information.ObjectiveIdentification of the specific symptoms that most motivate individuals to seek treatment information may offer insights for further improving brief interventions. To this end, we used anonymized internet search engine data to investigate which medical conditions and symptoms preceded searches for 12-step meeting locators and general 12-step information.MethodsWe extracted all queries made by people in the United States on the Bing search engine from November 2016 to July 2017. These queries were filtered for those who mentioned seeking Alcoholics Anonymous (AA) or Narcotics Anonymous (NA); in addition, queries that contained a medical symptom or condition or a synonym thereof were analyzed. We identified medical symptoms and conditions that predicted searches for seeking treatment at different time lags. Specifically, symptom queries were first determined to be significantly predictive of subsequent 12-step queries if the probability of querying a medical symptom by those who later sought information about the 12-step program exceeded the probability of that same query being made by a comparison group of all other Bing users in the United States. Second, we examined symptom queries preceding queries on the 12-step program at time lags of 0-7 days, 7-14 days, and 14-30 days, where the probability of asking about a medical symptom was greater in the 30-day time window preceding 12-step program information-seeking as compared to all previous times that the symptom was queried.ResultsIn our sample of 11,784 persons, we found 10 medical symptoms that predicted AA information seeking and 9 symptoms that predicted NA information seeking. Of these symptoms, a substantial number could be categorized as nonsevere in nature. Moreover, when medical symptom persistence was examined across a 1-month time period, a substantial number of nonsevere, yet persistent, symptoms were identified.ConclusionsOur results suggest that many common or nonsevere medical symptoms and conditions motivate subsequent interest in AA and NA programs. In addition to highlighting severe long-term consequences, brief interventions could be restructured to highlight how increasing substance misuse can worsen discomfort from common medical symptoms in the short term, as well as how these worsening symptoms could exacerbate social embarrassment or decrease physical attractiveness.
Digital Interventions to Support Adolescents and Young Adults With Cancer: Systematic Review
Authors: McCann Lisa , McMillan Kathryn Anne , Pugh Gemma 
Published: November 2019

Background
The last decade has seen an increase in the number of digital health interventions designed to support adolescents and young adults (AYAs) with cancer.

Objective
The objective of this review was to identify, characterize, and fully assess the quality, feasibility, and efficacy of existing digital health interventions developed specifically for AYAs, aged between 13 and 39 years, living with or beyond a cancer diagnosis.

Methods
Searches were performed in PubMed, EMBASE, and Web of Science to identify digital health interventions designed specifically for AYA living with or beyond a cancer diagnosis. Data on the characteristics and outcomes of each intervention were synthesized.

Results
A total of 4731 intervention studies were identified through the searches; 38 interventions (43 research papers) met the inclusion criteria. Most (20/38, 53%) were website-based interventions. Most studies focused on symptom management and medication adherence (15, 39%), behavior change (15, 39%), self-care (8, 21%), and emotional health (7, 18%). Most digital health interventions included multiple automated and communicative functions such as enriched information environments, automated follow-up messages, and access to peer support. Where reported (20, 53% of studies), AYAs’ subjective experience of using the digital platform was typically positive. The overall quality of the studies was found to be good (mean Quality Assessment Criteria for Evaluating Primary Research Papers from a Variety of Fields scores >68%). Some studies reported feasibility outcomes (uptake, acceptability, and attrition) but were not sufficiently powered to comment on intervention effects.

Conclusions
Numerous digital interventions have been developed and designed to support young people living with and beyond a diagnosis of cancer. However, many of these interventions have yet to be deployed, implemented, and evaluated at scale.
IN VITRO DISSOLUTION STUDY OF GLIMEPIRIDE FROM BINARY AND TERNARY SOLID DISPERSION FORMULATION
Authors: Akhter Sharmin , Hossen Md. Sajjad , Salahuddin Md. , Sunny Muazzem Ahmed , Sathi Farzana Akther , Islam Md. Shahidul 
Published: November 2019

Glimepiride (GMP) is poorly water soluble drug, so solubility is the main constraint for its oral bioavailability. Because, poor aqueous solubility and slow dissolution rate of the glimepiride lead to irreproducible clinical response or therapeutic failure in some cases due to sub therapeutic plasma drug levels. In this study, binary and ternary solid dispersion of glimepiride were prepared with polyethylene glycol 6000 (PEG 6000) and polyethylene glycol 4000 (PEG 4000) at different weight ratios using the solvent evaporation and melting method. It was found the drug was released 0.46% after 5 minutes and only 15.83% within 60 minutes from active glimepiride on the other hand the release pattern of glimepiride from the binary formulation containing PEG 4000 in 1:5 (Formulation coding: G5) showed the best result. It was found that the ternary different SD formulation containing(PEG4000:Glimepiride:Povidone) In ratio 1:1:0.25 (Formulation coding were : G13) showed the best result. The drug was changed to amorphous form after solid dispersion. Itwas also evident that solid dispersions improve solubility of drug particles thus enhancing dissolution characteristics of drugs they increase the oral bioavailability.
Peer Review History:
UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.
Received file

Average Peer review marks at initial stage: 4.5/10
Average Peer review marks at publication stage: 7.5/10
Reviewer(s) detail:
Name: Dr. Mohammed Abdel-Wahab Sayed Abourehab
Affiliation: Umm Al-Qura University; Makkah Al-Mukarramah, Saudi Arabia
E-mail: maabourehab@uqu.edu.sa

Name: Dr. Evren Alğin Yapar
Affiliation: Turkish Medicines and Medical Devices Agency, Turkiye
E-mail: evren.yapar@yahoo.com
Comments of reviewer(s):
The Effects of Aluminablasting on Bond Durability Between Universal Adhesives and Tooth Substrate
Authors: Ouchi H , Takamizawa T , Tsubota K , Tsujimoto A , Imai A , Barkmeier WW , Latta MA , Miyazaki M 
Published: November 2019

SUMMARY
The aim of this study was to determine the effect of aluminablasting on the bond durability of universal adhesives and adherent surface characteristics. Adhese Universal (Ivoclar Vivadent), All-Bond Universal (Bisco), Bondmer Lightless (Tokuyama Dental), G-Premio Bond (GC), and Scotchbond Universal (3M ESPE) were used in self-etch mode. The prepared bovine enamel and dentin specimens were divided into two groups based on whether they received an aluminablasting prior to application of the universal adhesives. The resin composite bonded specimens were stored in distilled water at 37°C for 24 hours, following which the shear bond strength (SBS) of half of the specimens was measured (24-hour group). The other half was subjected to 30,000 thermal cycles between 5 and 55°C before SBS measurement (TC group). Surface roughness (Ra) and surface free energy (SFE) of the adherent surfaces were also measured, and scanning electron microscopy observation and scanning electron microscopy/energy-dispersive X-ray analysis were carried out. Most of the adhesives did not show any significant differences in enamel SBS values between the two pretreatment groups, regardless of the storage condition. However, the dentin SBS values were significantly lower in specimens that underwent aluminablasting compared with those that did not, irrespective of their storage conditions. Significantly higher Ra and SFE values were observed in the enamel and dentin of specimens that underwent aluminablasting. Although aluminablasting increased the Ra and SFE values of enamel and dentin, its effect on the SBS value was dependent on the tooth substrate. In addition to C, O, Na, Mg, P, and Ca, the element Al was detected in the enamel and dentin of samples that had undergone aluminablasting. These results suggest that although aluminablasting of the tooth surface is thought to be effective for modification of the adherent surface, it may not enhance enamel bond performance and may also adversely affect the dentin bond effectiveness of the universal adhesives.
Contributions Of Human Resources Development, Leadership Style, Organizational Commitment, And Work Motivation On Good Governance And Police Officer Performance (Study Of Police Officer In South Sulawesi Regional Police)
Authors: Dong Muhammad , Mahfudnurnajamuddin Mahfudnurnajamuddin , Semmaila Baharuddin , Latief Baharuddin 
Published: November 2019

This purpose of this study was to contribution of human resource development, leadership style, commitment, and motivation on good governance and the performance of members of the Indonesian National Police and the effect of good governance on the performance of members of the Indonesian National Police in the South Sulawesi Regional Police. The study was using 230 police as a sample of a population of 5,069 police in 2019. Data were analyzed using by structural equation modeling with the AMOS assistance version 21. The results showed that (1) human resource development and motivation have a positive and significant effect on good governance and the police officer performance; (2) Leadership style has a negative and significant effect on good governance; (3) Commitment has a negative and insignificant effect on good governance; (4) Leadership style and commitment have a positive and significant effect on the police officer performance; and (6) Good governance has a positive and significant effect on the police officer performance.
Smart Enhancement of UPFC Performance in Transmission Systems Using BPSO and ANNC
Authors: Eiada Rabab Reda , Badran Ebrahim A. , Mansy Ibrahim I. I. 
Published: November 2019

The power disturbances in the transmission system can be controlled and reduced by using unified power flow controller (UPFC). UPFC is used for controlling power flow in electrical transmission system. In this paper an algorithm for optimizing and smart controlling of UPFC, using an artificial neural network controller (ANNC) and a Binary Particle Swarm Optimization (BPSO), is proposed for smarting transmission system. The proposed algorithm controls the parameters of the UPFC. Therefore, a best performance of the UPFC is achieved and the transmission losses are minimized at different load conditions and variation of generation. Matlab is used for simulating the proposed algorithm and the test system. The results show that the UPFC using the proposed algorithm effectively act the proposed requirements.
Performance Evaluation of Dynamic QoS-Aware CAC (DQA-CAC) Algorithm for Broadband Networks
Authors: Yese Solomon Orduen , Abdulazeez Abdulhakeem , Mohammed Aminu 
Published: November 2019

Call admission control (CAC) is a technique deployed in the management of network resources in mobile broadband networks. Despite its importance, the WiMAX technology like most mobile broadband networks does not make provision for CAC, making it an open area of research. A dynamic QoS-Aware Call Admission Control (DQACAC) scheme was recently proposed to improve resource utilization and ensure QoS. Several simulation experiments were conducted to evaluate the performance of the DQA-CAC against other CAC algorithms. The results of the simulation indicated that the DQA-CAC outperformed the existing CAC schemes in terms of reduced new connection blocking rate. However, the evaluation failed to consider other performance metrics like resource utilization and throughput that are also very crucial in the real-world scenario. This paper therefore attempts to improve the performance of the DQA-CAC by investigating its performance in terms of additional metrics like the average system throughput and resource utilization that further mimic the real-world experience. A Java based discrete event simulator designed for the study was used and the simulation results indicate that the DQA-CAC algorithm outperforms the existing CAC algorithms in terms of improved per-flow throughput, average system throughput and resource utilization in addition to reducing the connection blocking rate.
Detection of JAK2 V617F Mutation among Donors with Erythrocytosis
Authors: Mohammed Kamaruzzaman Siti Fatimah , Mohd Noor Noor Haslina , Hassan Mohd Nazri , Mohamed Yusoff Shafini , Abdullah Wan Zaidah 
Published: November 2019

Introduction: It is mandatory that every blood donor must have their haemoglobin (Hb) values measured before blood donation. High Hb may indicate an underlying hidden pathological condition. The aim of this study is to investigate the occurrence of the JAK2 V617F gene mutation in blood donors with erythrocytosis. Methods: A cross-sectional study was conducted over a nine-month period involving blood donors with high pre-donation Hb. A total of 45 blood donors with total white cell (TWC) > 12.0x 109/l, platelet > 450x109/ l and Hb > 18g/dL were subjected to JAK2 V617F gene mutation analysis. Samples were collected and analysed for haematological tests and detection of JAK2 V617F mutation. Results: From a total of 2238 blood donors, 175 blood donors had high haemoglobin value. Samples from forty-five of these donors were then analysed for JAK2 V617F using allele-specific polymerase chain reaction (PCR). The prevalence of blood donors with erythrocytosis was 7.8%. All samples were negative for the JAK2 V617F mutation. Conclusions: Erythrocytosis can be relative or absolute and the different causes can be distinguished on the basis of clinical signs and symptoms. An absence of the JAK2 V617F mutation cannot by itself excludes the diagnosis of polycyhaemia vera (PV) since erythrocytosis is the single clinical feature that sets PV apart from other types of myeloproliferative neoplasm (MPN). Further study is required for the detection of other gene mutations that activates the JAK-STAT signalling pathway that could be identified in JAK2 V617F-negative MPN patients. KEYWORDS: Blood donors, JAK 2 V617F mutation, erythrocytosis
The Lifestyle and Behavioural Risk Factors of Future Doctors in Universiti Teknologi MARA, Malaysia
Authors: Wee Chen Xin , Ismail Zaliha 
Published: November 2019

Introduction: Lifestyle and behavioural risk factors in middle-aged adults are proven to have an impact on later-life outcomes; hence health promotion activities should aim at the population before they reach their mid-life. Medical students will be representing a community in promoting health, henceforth they should have a healthy lifestyle and behaviour in order to facilitate and adoption of preventive practices in their future life as physicians. Therefore, this study was aimed to determine the lifestyle and behavioural risk factors among future doctors in a public university in Malaysia. Methods: A cross-sectional study was conducted at the Faculty of Medicine, Universiti Teknologi MARA (Sungai Buloh Campus). Simple random sampling was used to select eligible subjects among undergraduate medical students (pre-clinical years). A self-administered pro forma checklist was given to the subjects who consented. Descriptive analysis was performed, and univariate analysis was done by Chi-square, Fisher’s Exact test and independent t-test. Results: A total of 252 subjects participated. The majority (96.8%) were of Malay ethnicity and three-quarter of the subjects were females (76.2%). A small number of subjects were smokers (2.4%) and alcoholic consumers (1.2%). Approximately half (57.3%) of the female subjects had normal body mass indices, while this was only seen in one-third (35.0%) of male subjects. Most subjects (72.2%) exercised at least once a week, however only 17.1% of the subjects exercised at the recommended levels. There was a significantly higher proportion of males who had adequate exercise compared to that of females. Conclusion: Inadequate physical activity and imperfect BMI of the study subjects warrant exclusive promotion and education of healthy lifestyle in this population. It would probably be beneficial if assessment of lifestyle and behavioural risk factors could be conducted before these subjects embark into their professional working life. KEYWORDS: lifestyle, behaviour, risk factors, future doctors, Selangor.
An Overview of Lane Changing Model at Signalised Intersection
Authors: Md Diah Jezan , Tey Li Sian , Roslee Fathiyah 
Published: November 2019

In recent years, lane changing has become a crucial issue in traffic engineering and safety aspect due to distribution of vehicles across lanes thus contributing to traffic movements. In order to keep the right route, drivers have to change their lanes. However, lane changing has a high potential of accidents, especially at signalised intersection. This may cause the traffic flow to become heavier and traffic congestion. The aims of this study are to study on lane changing issue at signalised intersection, to determine the factors contributing to lane changing at signalised intersection and to develop a model for improvement of traffic flow in lane changing behaviour at signalised intersection. Lane changing model is important because it will reduce traffic congestion and smoothen the traffic. This study will contribute in studying the changing lane issue at signalised intersection which is to control the flow of traffic in order to ensure the traffic flows smoothly and to reduce traffic congestion especially on the merging issue at signalised intersection.
Keywords: lane changing, signalised intersection, model, traffic flow