bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrochemical performance and electrocatalytic behavior of myoglobin on graphene tube‐modified electrode
Authors: Niu Yanyan , Li Xiaoyan , Xie Hui , Luo Guiling , Zou Ruyi , Xi Yaru , Li Guangjiu , Sun Wei 
Published: November 2019

AbstractA new protein biosensing strategy based on a graphene tube (GT)‐modified electrode was developed in this article. GT as a fixed material and signal amplifier was loaded on the carbon ionic liquid electrode (CILE) surface, which could provide a suitable environment for myoglobin (Mb) immobilization and promote electron transfer between Mb and the electrode. Fourier‐transform infrared spectroscopy (FT‐IR) of Mb before and after mixing with GT was checked and showed that the native structure of Mb was maintained. The direct electrochemistry of Mb was investigated with a pair of obtained well‐defined and quasireversible redox peaks. The modified electrode (Nafion/Mb/GT/CILE) also showed excellent electrocatalytic activity for the reduction of trichloroacetic acid (TCA) and NaNO2, which could be utilized to determine the concentrations of TCA and NaNO2 with wide detection range and low detection limit. The biosensor was further applied to the detection of a real sample and obtained satisfactory experimental results.
The predictive value of microRNA‐21 for sepsis risk and its correlation with disease severity, systemic inflammation, and 28‐day mortality in sepsis patients
Authors: Na Lei , Ding Huajie , Xing Enhong , Zhang Yan , Gao Jun , Liu Bin , Yu Jian , Zhao Yanjun 
Published: November 2019

AbstractBackgroundThis study aimed to investigate the value of microRNA (miR)‐21 for predicting sepsis risk and its correlation with inflammation, disease severity as well as 28‐day mortality in sepsis patients.MethodsTotally, 219 sepsis patients and 219 healthy controls (HCs) were recruited. Plasma samples were obtained from sepsis patients within 24 hours after admission and from HCs at the enrollment to detect miR‐21 expressions by real‐time quantitative polymerase chain reaction. Besides, the clinical characteristics of sepsis patients were recorded and the 28‐day mortality of sepsis patients was evaluated.ResultsMiR‐21 expression was decreased in sepsis patients compared with HCs, and further receiver operating characteristic (ROC) curve analysis revealed that miR‐21 was of a good value in predicting sepsis risk (area under the curve [AUC]: 0.801, 95% CI: 0.758‐0.844). Besides, miR‐21 expression was negatively associated with acute pathologic and chronic health evaluation II (APACHE II) and sequential organ failure assessment (SOFA) score in sepsis patients. Furthermore, miR‐21 expression was negatively correlated with serum creatinine, C‐reactive protein, tumor necrosis factor‐α, interleukin (IL)‐1β, IL‐6, and IL‐17, while positively correlated with albumin in sepsis patients. However, there was no correlation of miR‐21 expression with white blood cell, smoke, or comorbidities in sepsis patients. Additionally, ROC curve analysis displayed that miR‐21 exhibited a poor predictive value for 28‐day mortality risk in sepsis patients (AUC: 0.588, 95% CI: 0.505‐0.672).ConclusionMiR‐21 might serve as a potential biomarker for the development and progression of sepsis, while not for prognosis prediction in sepsis patients.
Social media use and parent–child relationship: A cross‐sectional study of adolescents
Authors: Sampasa‐Kanyinga Hugues , Goldfield Gary S. , Kingsbury Mila , Clayborne Zahra , Colman Ian 
Published: November 2019

AbstractWe examined the association between social media use and parent–child relationship quality and tested whether this association is independent of total screen time. Data on 9,732 students (48.4% female) aged 11–20 years were obtained from a provincially representative school‐based survey. Heavy use of social media (daily use of more than 2 hr) was associated with greater odds of negative relationships between mother–daughter (odds ratio [OR] = 1.79; 95% confidence interval [CI]: 1.27–2.52), father–daughter (OR = 1.56; 95% CI: 1.16–2.09), father–son (OR = 2.19; 95% CI: 1.58–3.05) but not mother–son (OR = 1.17; 95% CI: 0.88–1.55). Results were similar after further adjusting for total screen time. There were no significant associations between regular use of social media (2 hr or less) and parent–child relationships. These findings suggest that heavy use of social media is associated with negative parent–child relationships. Longitudinal research is necessary to disentangle the pathways between social media use and the parent–child relationship.
Photocatalytic activity of Yb, Er, Ce‐codoped TiO2 for degradation of Rhodamine B and 4‐chlorophenol
Authors: Paeng Da Seul , Huy Bui The , Phuong Nguyen Thi Kim , Dao Van‐Duong , Lee Yong‐Ill 
Published: November 2019

AbstractBACKGROUNDPhotodegradation through an advanced oxidation process gives promising prospects for environmental protection. Although titanium dioxide (TiO2) is considered as an excellent photonic material candidate, however, the band gap of TiO2 is 3.2 eV which limits its effective applications. Various approaches have been developed for enhancing the utilization of TiO2 such as coupling with other narrow bandgap semiconductors and metal ions. We developed a novel ytterbium (Yb), erbium (Er), cerium (Ce)‐codoped TiO2 material as a high‐performance photocatalyst for efficient degradation of Rhodamine B (RhB) and 4‐chlorophenol (4‐CP) by hydrothermal technique. Yb, Er, and Ce ions served as electron collectors for the interfacial electrons transferred from TiO2, thus enhancing the separation of the photo‐induced electron–hole pairs.RESULTSThe photocatalytic activity of the prepared TiO2–Er0.15Yb0.15Ce0.14 sample is higher than those of undoped TiO2, TiO2–Ce0.3 and TiO2–Er0.15Yb0.15 samples under optimal condition. Our developed catalyst degraded 98% of 0.04 mM RhB and 95% of 0.6 mM 4‐CP under white light irradiation for 60 and 240 min, respectively. Moreover, a probable photodegradation mechanism is proposed.CONCLUSIONTiO2–Er0.15Yb0.15Ce0.14 with high photocatalytic degradation efficiency under white light irradiation was synthesized by a hydrothermal method. Yb3+, Er3+, Ce4+ played a role as photo‐induced electron collectors to suppress the recombination of photo‐induced electron–hole pairs. The synthesized material has a high potential as an efficient photocatalyst for toxic pollutants in aqueous media. © 2019 Society of Chemical Industry
Tree matchings
Authors: Roberts Alexander 
Published: November 2019

AbstractAn ‐matching in a bipartite graph is a subset of the edges such that each component of is a tree with at most edges and each vertex in has neighbours in . We give sharp sufficient neighbourhood‐conditions for a bipartite graph to contain an ‐matching. As a special case, we prove a conjecture of Bennett, Bonacina, Galesi, Huynh, Molloy and Wollan.
Synthesis and DABCO‐induced demethylation of 3‐cyano‐4‐methoxy‐2‐pyridone derivatives
Authors: Li Jing , Tan Hong‐Ru , An Yu‐Long , Shao Zhi‐Yu , Zhao Sheng‐Yin 
Published: November 2019

AbstractAn efficient method for synthesis and demethylation of 3‐cyano‐4‐methoxy‐2‐pyridone derivatives has been developed. DABCO‐induced demethylation can lead to 3‐cyano‐4‐hydroxy‐2‐pyridones in DMF at 90°C with high yield. The protocol is applicable for the synthesis of 3‐cyano‐4‐hydroxy‐2‐pyridone derivatives. The method is simple, efficient, and practical.
Morquio‐B disease: Clinical and genetic characteristics of a distinct GLB1‐related dysostosis multiplex
Authors: Abumansour Iman S. , Yuskiv Nataliya , Paschke Eduard , Stockler‐Ipsiroglu Sylvia 
Published: November 2019

AbstractBackgroundMorquio‐B disease (MBD) is a distinct GLB1‐related dysostosis multiplex involving the trabecular parts of long bones and spine, presenting a mild phenocopy of GALNS‐related Morquio‐A disease.MethodsWe analyzed 63 (n = 62 published) cases with MBD to describe their clinical, biochemical and genetic features.ResultsForty‐one of 51 cases with informative clinical data had pure MBD including progressive growth impairment, kyphoscoliosis, coxa/genua valga, joint laxity, platyspondyly, odontoid hypoplasia. Ten of 51 had MBD plus neuronopathic manifestations including intellectual/developmental/speech delay, spasticity, ataxia dystonia. Corneal clouding, cardiac valve pathology, hepatosplenomegaly, spinal cord compression were infrequent and atlantooccipital dislocation, cardiomyopathy and cherry red spot were never reported. Urinary glycosaminoglycan and oligosaccharide excretion was consistently abnormal. Keratan sulphate‐derived oligosaccharides were only detected using LC‐MS/MS‐based methods. Residual β‐galactosidase activities measured against synthetic substrates were 0%‐17%.Among 28 GLB1 variants, W273 L (34/94 alleles) and T500A (11/94 alleles) occurred most frequently. W273L was invariably associated with pure MBD. Pure MBD also was reported in a case homozygous for R201H, and in the majority of cases carrying the T500A variant. Homozygous Y333C and G438E were associated with MBD plus neuronopathic manifestations. T82M, R201H, and H281Y, observed in seven alleles, previously have been found sensitive to experimental chaperones.ConclusionData provide a basis for future systematic collection of clinical, biochemical, morphologic, and genetic data of this ultra‐rare condition.
Projected changes in extreme precipitation over eastern Asia in the 21st century
Authors: Wang Chenghai , Cui Danyang , Santisirisomboon Jerasorn 
Published: November 2019

AbstractThis study used a multi‐model ensemble (MME) simulation to project changes in extreme precipitation (EP) over the next century based on four relevant indexes (R95P, FRE, total precipitation [PRCPTOT] and PPER) during the monsoon period (May–September) over eastern Asia. The ensemble model was built from three global climate models from the Coupled Model Inter‐comparison Project Phase 5. The results indicate that the MME results can reproduce observations of the spatial distribution characteristics of EP indexes in eastern Asia. Compared with the reference period of 1986–2005, the EP (R95P), PRCPTOT and the ratio of EP to PRCPTOT (PPER) in eastern Asia will increase during the monsoon period under the three emission scenarios in three durations (the early period: 2020–2039, middle period: 2050–2069 and late period: 2080–2099) throughout the 21st century. This feature is especially strong in southeast China and the Malay Islands. Meanwhile, the variation in the frequency of EP events (FRE) has prominent regional differences, including a decrease in the Yellow River Basin and the Indochina Peninsula and an increase in southeast China. All projected increasing were most significant under high emissions (RCP8.5). This study also suggests that EP would not generally increase in frequency but rather in intensity. With an increase in emissions concentration, the temperature threshold at which EP occurs is likely to rise, so the EP might need triggered by the higher temperatures.
Standard chemical‐based tephra extraction methods significantly alter the geochemistry of volcanic glass shards
Authors: Cooper Claire L. , Savov Ivan P. , Swindles Graeme T. 
Published: November 2019

ABSTRACTThe chemical compositions of tephra shards are widely utilised in a myriad of disciplines, including volcanology, petrology, tephrochronology, palaeoecology and climate studies. Previous research has raised concerns over the possible chemical alteration of microscopic (<100 µm) volcanic glass shards through standard extraction procedures, such as the widely used acid digestion method. This study subjects 10 samples of well‐characterised volcanic glasses ranging from basalt to rhyolite to three common methods used in the extraction of volcanic material from lake sediments and peats. The major element geochemistry of each sample was analysed and compared with a control group. The results of this test indicate that basaltic and andesitic glasses are highly susceptible to chemical alteration, particularly to the concentrated corrosive materials used in acid and base digestion techniques. PERMANOVA analysis of the variation within groups suggests that the oxides most susceptible to variation are alkalis from groups I and II (K2O, Na2O, CaO, MgO) and SiO2, and the most stable oxides are Al2O3 and FeO. Felsic glasses are considerably less susceptible to alteration by both acidic (HCl, HNO3, H2SO4) and alkaline (KOH) digestions. Our findings have important implications for interpreting the geochemistry of volcanic glasses. Copyright © 2019 John Wiley & Sons, Ltd.
Guidelines of the Brazilian Society of Oncologic Surgery for pelvic exenteration in the treatment of cervical cancer
Authors: Laporte Gustavo A. , Zanini Lucas A. G. , Zanvettor Paulo H. , Oliveira Alexandre F. , Bernado Enio , Lissa Fernando , Coelho Manoel J. P. , Ribeiro Reitan , Araujo Raphael L. C. , Barrozo Abner J. J. , da Costa Alexandre F. , de Barros Júnior Amario P. , Lopes Andre , Santos Antônio P. M. , Azevedo Bruno R. B. , Sarmento Bruno J. Q. , Marins Carlos A. M. , Loureiro Carlos M. B. , Galhardo Cezar A. V. , Gatelli Charles N. , Quadros Claudio A. , Pinto Cláudio V. , Uchôa Diego N. A. O. , Martins Diogo R. S. , Doria‐Filho Eduardo , Ribeiro Ellen K. M. A. , Pinto Eric R. F. , dos Santos Evandro A. S. , Gozi Francisco A. M. , Nascimento Francisco C. , Fernandes Francisco G. , Gomes Francisco K. L. , Nascimento Geraldo J. S. , Cucolicchio Guilherme O. , Ritt Guilherme F. , de Oliveira Guilherme G. , Ayala Gunther P. , Guimarães Gustavo C. , Ianaze Gustavo C. , Gobetti Gustavo A. , Medeiros Gustavo M. , Güth Gustavo Z. , Neto Heládio F. C. , Figueiredo Higino F. , Simões João C. , Ferrari José C. , Furtado José P. R. , Vieira Leonardo J. , Pereira Lucas F. , de Almeida Luiz C. F. , Tayeh Muhamed R. A. , Figueiredo Pedro H. M. , Pereira Rafael S. A. V. , Macedo Ramon O. , Sacramento Raquel M. M. , Cardoso Rayane M. , Zanatto Renato M. , Martinho Rodrigo A. M. , Araújo Rodrigo G. , Pinheiro Rodrigo N. , Reis Rosilene J. , Goiânia Sergio B. S. , Costa Sergio R. P. , Foiato Tariane F. , Silva Tyrone C. , Carneiro Vandré C. G. , Oliveira Viviane R. , Casteleins William A. 
Published: November 2019

AbstractBackground and ObjectivesThe primary treatment for locally advanced cases of cervical cancer is chemoradiation followed by high‐dose brachytherapy. When this treatment fails, pelvic exenteration (PE) is an option in some cases. This study aimed to develop recommendations for the best management of patients with cervical cancer undergoing salvage PE.MethodsA questionnaire was administered to all members of the Brazilian Society of Surgical Oncology. Of them, 68 surgeons participated in the study and were divided into 10 working groups. A literature review of studies retrieved from the National Library of Medicine database was carried out on topics chosen by the participants. These topics were indications for curative and palliative PE, preoperative and intraoperative evaluation of tumor resectability, access routes and surgical techniques, PE classification, urinary, vaginal, intestinal, and pelvic floor reconstructions, and postoperative follow‐up. To define the level of evidence and strength of each recommendation, an adapted version of the Infectious Diseases Society of America Health Service rating system was used.ResultsMost conducts and management strategies reviewed were strongly recommended by the participants.ConclusionsGuidelines outlining strategies for PE in the treatment of persistent or relapsed cervical cancer were developed and are based on the best evidence available in the literature.
Near‐Infrared Tunable Surface Lattice Induced Transparency in a Plasmonic Metasurface
Authors: Michaeli Lior , Suchowski Haim , Ellenbogen Tal 
Published: November 2019

AbstractCollective coherent scattering at the surface of a plasmonic nanoparticle array is shown to induce tunable transparency windows at the localized plasmon band. Broadband phase measurements show that the enhanced transmission is accompanied by a large anomalous dispersion, which leads to a group delay as large as within only 40 nm thick sample. This effect occurs over a wide tunable spectral range of , and appears for two distinct counter‐propagating surface waves. The experimental observations are in good agreement with calculations based on coupled dipole approximation (CDA) and with finite‐difference time‐domain (FDTD) simulations. This study opens the door for implementation in the fields of sensing, displays, optical buffering, tunable filtering, and nonlinear optics.
The impact of the implicit theories of social optimism and social pessimism on macro attitudes towards consumption
Authors: Muncy James A. , Iyer Rajesh 
Published: November 2019

AbstractPeople have substantially differing attitudes towards consumption. Anti‐consumers are negative towards consumption. In contrast, pro‐consumers view consumption in a positive light. We posit that people's attitudes toward consumption at the societal (macro) level are impacted by the implicit theories they hold about whether society can solve the problems it faces. We identify two different implicit theories consumers hold regarding how solvable larger societal problems are. Social optimists believe that we will solve the problems that are emerging as we evolve at the societal level. In contrast, social pessimists believe that societal evolution is creating problems too large to be solved. We developed a macro attitudes model where social optimism and pessimism were posited to impact people's macro attitudes towards consumption. We present the results of a study that found that social optimists have more positive attitudes towards consumption and social pessimists have more negative attitudes towards consumption. We also found that this model provided a superior fit in comparison to three other plausible models relating implicit theories and attitudes towards consumption. These findings have implications for anti‐consumption research, consumer research on implicit theories, and social marketing designed to address problems associated with overconsumption.
3D Printing of Supramolecular Polymers: Impact of Nanoparticles and Phase Separation on Printability
Authors: Rupp Harald , Döhler Diana , Hilgeroth Philipp , Mahmood Nasir , Beiner Mario , Binder Wolfgang H. 
Published: November 2019

Abstract3D printing of linear and three‐arm star supramolecular polymers with attached hydrogen bonds and their nanocomposites is reported. The concept is based on hydrogen‐bonded supramolecular polymers, known to form nano‐sized micellar clusters. Printability is based on reversible thermal‐ and shear‐induced dissociation of a supramolecular polymer network, which generates stable and self‐supported structures after printing, as checked via melt‐rheology and X‐ray scattering. The linear and three‐arm star poly(isobutylene)s PIB‐B2 (Mn = 8500 g mol −1), PIB‐B3 (Mn = 16 000 g mol −1), and linear poly(ethylene glycol)s PEG‐B2 (Mn = 900 g mol−1, 8500 g mol −1) are prepared and then probed by melt‐rheology to adjust the viscosity to address the proper printing window. The supramolecular PIB polymers show a rubber‐like behavior and are able to form self‐supported 3D printed objects at room temperature and below, reaching polymer strand diameters down to 200–300 µm. Nanocomposites of PIB‐B2 with silica nanoparticles (12 nm, 5–15 wt%) are generated, in turn leading to an improvement of their shape persistence. A blend of the linear polymer PIB‐B2 and the three‐arm star polymer PIB‐B3 (ratio ≈ 3/1 mol) reaches an even higher structural stability, able to build free‐standing structures.
Orofacial muscles may be affected in early stages of Becker muscular dystrophy: A preliminary study
Authors: Lagarde Marloes L.J. , van Alfen Nens , Geurts Alexander C.H. , de Groot Imelda J.M. , van den Engel‐Hoek Lenie 
Published: November 2019

AbstractBackgroundDysphagia is reported in patients with Duchenne or Becker muscular dystrophy. Our clinical experience suggests that, compared with Duchenne patients, impaired mastication and swallowing occur early in Becker patients relative to their skeletal muscle involvement. The aim of this study was to assess dysphagia in Duchenne and Becker patients in relation to ambulatory capacity.MethodsIn patients in the early ambulatory stage, clinical symptoms, quantitative muscle ultrasound of the orofacial muscles, and maximum bite force were assessed. The 6‐Minute Walk Test (6MWT) was used to measure ambulatory capacity.ResultsEleven Duchenne and 11 Becker patients were included. Although Becker patients had a greater 6MWT distance than Duchenne patients, the occurrence of mastication and swallowing difficulties was similar. The temporalis muscle was significantly thicker in Becker patients.ConclusionsClinicians should be aware of dysphagia in both groups, even when ambulation is still well preserved.
Heart analytics: Analytical modeling of cardiovascular care
Authors: Dai Tinglong , Gleason Kelly , Hwang Chao‐Wei , Davidson Patricia 
Published: November 2019

AbstractCardiovascular diseases (CVDs) are the leading cause of death and disability both in the United States and worldwide. Despite high morbidity, mortality, and cost in the United States and global healthcare systems, cardiovascular care has been understudied in the healthcare operations management literature. In this paper, we identify research opportunities for healthcare operations management scholars to aid in improving cardiovascular care. We focus on three burdensome conditions, including (1) coronary artery disease, (2) stroke, and (3) heart failure, which, collectively, lead to the vast majority of CVD‐caused mortality and disability. For each condition, we characterize a typical patient's journey in receiving cardiovascular care, elucidating key challenges in improving care and outlining research questions for healthcare operations management scholars. We close with a reference to new research opportunities that emerge as artificial intelligence is likely to transform much of cardiovascular care.
Optimal drug control in a four‐dimensional HIV infection model
Authors: Shamsara Elham , Afsharnezhad Zahra , Effati Sohrab 
Published: November 2019

SummaryIn this paper, we consider a four‐dimensional version of a human immunodeficiency virus (HIV) infection model, which is an extension of some previous three‐dimensional models. We approach the treatment problem by adding two controls u1 and u2 to the system for inhibiting viral production and preventing new infections. In fact, u1 is added to components of uninfected and infected cells to represent the effect of chemotherapy on the interaction of uninfected CD4+ T cells with infected cells. u2 is considered in the effector immune component as immunotherapy. The purpose of this work is to control the progress of the disease in a steady state. Hence, first, we obtain a relation between the two controls u1 and u2 such that a Hopf bifurcation occurs. Next, the Pontryagin minimum principle will be applied to derive the optimal therapy for HIV. At the end, numerical results are presented.