bluuebunny/crossref_metadata_2025_split huggingface dataset:
CTDSP1 inhibitor rabeprazole regulates DNA-PKcs dependent topoisomerase I degradation and irinotecan drug resistance in colorectal cancer
Authors: Matsuoka Hiroya , Ando Koji , Swayze Emma J , Unan Elizabeth C , Mathew Joseph , Hu Quingjiang , Tsuda Yasuo , Nakashima Yuichiro , Saeki Hiroshi , Oki Eiji , Bharti Ajit K , Mori Masaki 
Published: January 2020

AbstractIrinotecan specifically targets topoisomerase I (topoI), and is used to treat various solid tumors, but only 13-32% of patients respond to the therapy. Now, it is understood that the rapid rate of topoI degradation in response to irinotecan causes irinotecan resistance. We have published that the deregulated DNA-PKcs kinase cascade ensures rapid degradation of topoI and is at the core of the drug resistance mechanism of topoI inhibitors, including irinotecan. We also identified CTD small phosphatase 1 (CTDSP1) (a nuclear phosphatase) as a primary upstream regulator of DNA-PKcs in response to topoI inhibitors. Previous reports showed that rabeprazole, a proton pump inhibitor (PPI) inhibits CTDSP1 activity. The purpose of this study was to confirm the effects of rabeprazole on CTDSP1 activity and its impact on colon cancer. Using HCT116 and HT29, with high and low CTDSP1 expression respectively and a retrospective analysis of patients receiving irinotecan with or without rabeprazole have indicated the effect of CTDSP1 in irinotecan response. These results indicate that CTDSP1 promotes sensitivity to irinotecan and rabeprazole prevents this effect, resulting in drug resistance. To ensure the best chance at effective treatment, rabeprazole may not be a suitable PPI for cancer patients treated with irinotecan.
Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons
Authors: Ji Daisy X. , Witt Kristen C. , Kotov Dmitri I. , Margolis Shally R. , Louie Alexander , Chevée Victoria , Chen Katherine J. , Gaidt Moritz , Dhaliwal Harmandeep S. , Lee Angus Y. , Nishimura Stephen , Zamboni Dario S. , Kramnik Igor , Portnoy Daniel A. , Darwin K. Heran , Vance Russell E. 
Published: January 2020

AbstractType I interferons (IFNs) are essential for anti-viral immunity, but often impair protective immune responses during bacterial infections. An important question is how type I IFNs are strongly induced during viral infections, and yet are appropriately restrained during bacterial infections. TheSuper susceptibility to tuberculosis 1 (Sst1)locus in mice confers resistance to diverse bacterial infections. Here we provide evidence thatSp140is a gene encoded within theSst1locus that represses type I IFN transcription during bacterial infections. We generatedSp140-/-mice and find they are susceptible to infection byLegionella pneumophilaandMycobacterium tuberculosis.Susceptibility ofSp140-/-mice to bacterial infection was rescued by crosses to mice lacking the type I IFN receptor(Ifnar-/-). Our results implicateSp140as an important negative regulator of type I IFNs that is essential for resistance to bacterial infections.Impact StatementRepression of type I interferons by SP140 is essential for resistance toLegionella pneumophilaandMycobacterium tuberculosis.
Effect of Al on microstructure and mechanical properties of as-cast Mg-8Gd-4Y-1Zn alloy
Authors: Zhou Yongxin , Li Qian , Xing Zhiguo , Zhou Renze , Huang Zhenhua , Huang Yanfei , Guo Weiling 
Published: January 2020

Purpose
This paper aims to investigate the effect of aluminum addition on the microstructure and mechanical properties of Mg-8Gd-4Y-1Zn alloy.

Design/methodology/approach
Mg-8Gd-4Y-1Zn-xAl (x = 0, 0.5, 1.0, 1.5, 2.0 Wt.%) alloys were prepared by the conventional gravity casting technology, and then microstructures, phase composition and mechanical properties were investigated by material characterization method, systematically.

Findings
Results show that the as-cast microstructure of Mg-8Gd-4Y-1Zn alloy mainly consists of a-Mg matrix as well as Mg12REZn (18 R LPSO structure), and island-like Mg3(RE, Zn) phase is distributed at the grain boundary. The addition of a small amount of Al (0.5 Wt.%) can decrease the content of island-like Mg3(RE, Zn) phase, but significantly increase the content of long-period stacking ordered (LPSO) structure, resulting in the improvement of both tensile strength and elongation of Mg-8Gd-4Y-1Zn alloy. However, the addition of excessive Al will consume Re element and decrease the amount of LPSO structure, leading to the decrease of tensile properties. When the content of Al is 0.5 Wt.%, the tensile strength and elongation are 225 MPa and 9.0% of Mg-8Gd-4Y-1Zn alloy, which are 14% and 29% higher than that of Mg-8Gd-4Y-1Zn alloy, respectively.

Originality/value
Adding aluminum to Mg-8Gd-4Y-1Zn alloy strengthens its mechanical properties. And the effect of Al content on the alloy strengthening. The formation mechanism of LPSO structure with different aluminum content was revealed.
The dynamic effects of monetary policy innovations in Ethiopia
Authors: Nuru Naser Yenus 
Published: January 2020

Purpose
The purpose of this paper is to investigate the effects of unanticipated monetary policy innovations on output and price for Ethiopia from 1991:Q1 to 2016:Q1.

Design/methodology/approach
Short run and long run identification schemes on structural vector autoregressive model are employed in this study.

Findings
The impulse response function results generated show that while a positive shock in interest rate causes a reduction in output and price puzzle, a positive shock to broad money supply has a positive and significant effect on output and price. A positive shock in real effective exchange rate has also an expansionary, though insignificant, effect on impact on both output and price. These results are especially true for the short run identification scheme. As to the results from the variance decomposition, the study shows that the highest variation in output and price is caused by broad money supply shock in the short run.

Originality/value
It adds to the scarce empirical literature on the effects of monetary policy innovations on the Ethiopian economy.
Audit effort, materiality and audit fees: evidence from the adoption of IFRS in Australia
Authors: Miah Muhammad Shahin , Jiang Haiyan , Rahman Asheq , Stent Warwick 
Published: January 2020

PurposeThis paper aims to investigate the association between International Financial Reporting Standards (IFRS) effort due to higher levels of material adjustments and audit fees. In addition, this paper tests whether these associations differ between industry specialist auditors and non-specialist auditors.Design/methodology/approachThe authors measure IFRS effort by using differences between local GAAP and IFRS. More specifically, they measure the differences in the balances of accounts that are prepared under IFRS as opposed to the previously used Australian Accounting Standards Board (AASB) standards. They posit that higher material adjustments and more risk to fair presentation of financial statements require additional accounting and auditing effort (“IFRS effort”).FindingsThe authors find that audit fees are higher when accounting standards are more material and complex at an aggregate level. Nevertheless, not all standards are equally complex and/or material and not all individual standards contribute to higher audit fees. In addition, the results show that the positive association between IFRS effort and audit fees is more pronounced when firms are audited by city-level industry specialists than by non-industry specialists.Originality/valueOverall, the results are consistent with the prediction of increasing audit fees for firms requiring higher levels of IFRS effort compared to firms requiring lower levels of IFRS effort. The results contribute to the understanding that not all IFRS are equally complex and, thereby, the standards require different levels of auditor effort. Isolating specific standards based on materiality/risk levels is informative to standard setters for standard setting, standard implementation and post-implementation review of standards.
Does organizational virtuousness and psychological capital impact employee performance: evidence from the banking sector
Authors: Dubey Shubha , Ruparel Namita , Choubisa Rajneesh 
Published: January 2020

Purpose
Positive psychology views organizational virtuousness (OV) and psychological capital (PsyCap) as significant external and internal variables. From a research perspective, both OV and PsyCap have indicated a positive relationship with employee performance. However, the underlying mechanism of the causal relationship needs to be explored.

Design/methodology/approach
The study employed a cross-sectional design. The sample was collected through snowball technique from (n = 122) Indian bank employees from the public (51 per cent) and private sector (49 per cent).

Findings
OV and PsyCap reveal a positive effect on self and supervisor-rated performance of the Indian bankers. OV predicts PsyCap. Overall, OV and PsyCap impacts supervisor-rated performance.

Research limitations/implications
Our study demonstrates that organizations can develop employee OV to enhance their PsyCap. It is essential to improve their perceptions of OV. Moreover, this relationship also empowers employee performance, thereby emphasizing the importance of OV among employees, managers and organizations. Study findings seem robust, but other researchers should extend this work into other sectors and with larger sample sizes.

Originality/value
Our study is the first to explore the relationships between OV and PsyCap. Also, it assesses the variable’s impact on self and supervisor rated performance. The results of our study provide insights into banking employees' performance that managers can use in their daily operations.
Quantitative assessment of landslide risk using Monte Carlo material point method
Authors: Zhou Xiaomin , Sun Zheng 
Published: January 2020

PurposeThe purpose of this paper is to provide an effective way to assess landslide risk quantitatively. Quantitative assessment plays an important role in mitigating the landslide risk and developing a landslide risk-based warning system. However, efficient risk assessment on the large deformation failure process of slope with spatially variable soils is a challenging problem.Design/methodology/approachCombining the Monte Carlo simulation (MCS) and the higher-order material point method – the B-spline Material Point Method (BSMPM) – the concept of MC-BSMPM to assess the landslide risk quantitatively is proposed in this paper. The overall dynamic evolution of soil slope failure has been simulated by the BSMPM, and the probability density function of the sliding duration, the sliding kinematic energy, the sliding mass and the sliding distance of the landslide are obtained based on the MCS. Through the four risk assessment parameters of the sliding duration, the sliding kinematic energy, the sliding mass and the sliding distance, the landslide risk could be assessed quantitatively.FindingsIt is found that the post-failure behavior of the landslide conforms well to a normal distribution as the soil physical parameter is in a normal distribution. The variation of soil’s shear strength affects the dynamic motion of the landslide greatly.Originality/valueThe result shows that the landslide hazard cannot be estimated comprehensively by the deterministic BSMPM, while the landslide risk could be more clearly understood and quantitatively assessed with more details by the proposed method, which demonstrates that the MC-BSMPM method is an effective way to assess the landslide risk quantitatively.
Green-Haar method for fractional partial differential equations
Authors: Ismail Muhammad , Rehman Mujeeb ur , Saeed Umer 
Published: January 2020

Purpose
The purpose of this study is to obtain the numerical scheme of finding the numerical solutions of arbitrary order partial differential equations subject to the initial and boundary conditions.

Design/methodology/approach
The authors present a novel Green-Haar approach for the family of fractional partial differential equations. The method comprises a combination of Haar wavelet method with the Green function. To handle the nonlinear fractional partial differential equations the authors use Picard technique along with Green-Haar method.

Findings
The results for some numerical examples are documented in tabular and graphical form to elaborate on the efficiency and precision of the suggested method. The obtained results by proposed method are compared with the Haar wavelet method. The method is better than the conventional Haar wavelet method, for the tested problems, in terms of accuracy. Moreover, for the convergence of the proposed technique, inequality is derived in the context of error analysis.

Practical implications
The authors present numerical solutions for nonlinear Burger’s partial differential equations and two-term partial differential equations.

Originality/value
Engineers and applied scientists may use the present method for solving fractional models appearing in applications.
When more is better
Authors: Valenzuela Marcus A. , Jian Guowei , Jolly Phillip M. 
Published: January 2020

PurposeThe purpose of this paper is to examine how organizational diversity may be associated with immigrants’ quality of coworker relationships. More specifically, this paper examines how immigrants’ perceived deep-level similarity and perceived workplace ethnic diversity may be associated with their quality of coworker relationships.Design/methodology/approachA final sample of 347 immigrant employees were surveyed. Hierarchical regression analyses were conducted to test the hypotheses.FindingsImmigrants’ quality of coworker relationships is positively associated with their perceived deep-level similarity with other coworkers. In addition, perceived workplace ethnic diversity moderates this relationship such that the relation is stronger as perceived workplace ethnic diversity increases.Research limitations/implicationsThe study and analyses are based on cross-sectional and single-source data and cannot determine causality. The study is also restricted to immigrants in the USA.Practical implicationsFindings provide evidence that increased levels of ethnic diversity and deep-level similarity in the workplace may improve immigrants’ quality of relationships, helping them integrate more successfully in organizations. Thus, managers seeking to benefit from diversity should strive for the creation of truly multicultural organizations or workgroups and focus on fostering similarities in deep-level attributes to maximize their potential.Originality/valueImmigrants are an important asset for organizations, but research about their inclusion in organizations is limited, especially when examining their integration in their workplaces. This study addresses some of these limitations by looking at the effect of diversity in organizations.
A multiphase SPH framework for solving the evaporation and combustion process of droplets
Authors: Wang Dudou , Qiang Hongfu , Shi Chao 
Published: January 2020

Purpose
This paper aims to introduce a two-dimensional smoothed particle hydrodynamics (SPH) framework for simulating the evaporation and combustion process of fuel droplets.

Design/methodology/approach
To solve the gas–liquid two-phase flow problem, a multiphase SPH method capable of handling high density-ratio problems is established. Based on the Fourier heat conduction equation and Fick’s law of diffusion, the SPH discrete equations are derived. To effectively characterize the phase transition problem, inspired by volume of fluid method, the concept of liquid phase mass fraction of the SPH particles is proposed. The one-step global reaction model of n-hexane is used for the vapor combustion.

Findings
The evaporation and combustion process of single droplet conforms to the law. The framework works out well when the evaporation of multiple droplets involves coalescence process. Three different kinds of flames are observed in succession in the combustion process of a single droplet at different inflow velocity, which agree well with the results of the experiment.

Originality/value
To the best of the authors’ knowledge, this is the first computational framework that has the capability to simulate evaporation and combustion with SPH method. Based on the particle nature of SPH method, the framework has natural advantages in interface tracking.
How are we tempted into debt? Emotional appeals in loan advertisements in UK newspapers
Authors: Czarnecka Barbara , Mogaji Emmanuel 
Published: January 2020

Purpose
The purpose of this paper is to examine the use of emotional appeals in advertisements for loans and explored consumers’ perceptions of advertisements featuring such appeals in order to explore how emotional meanings are transferred to consumers via advertising.

Design/methodology/approach
Study 1 employed content analysis to examine the use of emotional appeals in loan advertisements. Over 2,900 editions of eight British newspapers were monitored for advertisements for loans containing emotional appeals. Study 2 employed 33 semi-structured interviews to explore consumers’ perceptions of emotional appeals in loan advertisements.

Findings
Loans were positioned as services providing relief, security and excitement. The use of negative emotional appeals such as guilt, fear and sorrow was sporadic. Loans that carried the most risk were advertised with positive emotional appeals the most frequently. Five dimensions of perceptions of emotional loan advertisements were conceptualised from the reported data in Study 2.

Originality/value
This is the first study in the UK to examine the use of emotional appeals in loan advertising and to explore consumers’ perceptions of loan advertisements featuring emotional appeals. The study identified five dimensions of perceptions of emotional appeals.
Predicting customer satisfaction for distribution companies using machine learning
Authors: Cavalcante Siebert Luciano , Bianchi Filho José Francisco , Silva Júnior Eunelson José da , Kazumi Yamakawa Eduardo , Catapan Angela 
Published: January 2020

Purpose
This study aims to support electricity distribution companies on measuring and predicting customer satisfaction.

Design/methodology/approach
The developed methodology selects and applies machine learning techniques such as decision trees, support vector machines and ensemble learning to predict customer satisfaction from service data, power outage data and reliability indices.

Findings
The results on the predicted main indicator diverged only by 1.36 per cent of the results obtained by the survey with company customers.

Research limitations/implications
Social, economic and political conjunctures of the regional and national scenario can influence the indicators beyond the input variables considered in this paper.

Practical implications
Currently, the actions taken to increase customer satisfaction are based on the track record of a yearly survey; therefore, the methodology may assist in identifying disturbances on customer satisfaction, enabling decision-making to deal with it in a timely manner.

Originality/value
Development of an intelligent algorithm that can improve its performance with time. Understanding customer satisfaction may improve companies’ performance.
The mediation role of public governance in the relationship between entrepreneurship and economic growth
Authors: Hamdan Allam Mohammed , Khamis Reem , Al Hawaj Ammar Abdulla , Barone Elisabetta 
Published: January 2020

PurposeThe purpose of this paper is to investigate the mediation role of public governance in the relationship between entrepreneurship and economic growth in the United Arab Emirates (UAE).Design/methodology/approachTo achieve this aim, the study uses a 20-year time series analysis (1996–2015) and tests the effect of entrepreneurship on economic growth, through public governance, via a mediator model.FindingsThe study has determined that public governance buoys the positive effect that entrepreneurship activities exert on economic growth in the UAE. Based on this determination, the study posits a set of recommendations that focus on supporting entrepreneurship activities that play a significant role in economic growth.Originality/valueThe study adds to the literature on the impact of entrepreneurship on economies dependent on oil revenuesvis-à-visa public policy perspective. The study provides insights into the type of entrepreneurship that most efficaciously suits the Emirati social and cultural milieu in terms of fostering national economic growth. In addition, the study limns a vision of the role of public governance in creating an enabling environment that stimulates entrepreneurial activity and, in turn, increases economic growth in the Emirates.
Implementing self-service technologies: not without competition!
Authors: Audrin Bertrand 
Published: January 2020

PurposeThe purpose of this paper is to explore the implementation of self-service technologies (SST) in two competitors and unravel the process of change in two related setups, offering a comparison as well as an association of cases.Design/methodology/approachThe paper is based on two extensive case studies of SST adoption by leading retailers in a Western European country. The analysis is based on a material-discursive approach using Greimas actantial model to identify actors’ roles in the implementation process.FindingsResults highlight the key role of technology and organizational identity as legitimizers of the change process. The findings also emphasize the role of competition in justifying change.Research limitations/implicationsDue to the specific situation of the market in the country of study (both retailers share 70 percent of the grocery market), this research offers a textbook example of the role of competition in technological change. This helps to understand the role of competition in technological change.Originality/valueThis study explores the implementation of SST in two competitors and unravels the process of change in two related setups, offering a comparison as well as an association of cases.
How long is a parental leave and for whom? An analysis of methodological and policy dimensions of leave length and division in Sweden
Authors: Duvander Ann-Zofie , Viklund Ida 
Published: January 2020

PurposeParental leave in Sweden can be taken both as paid and unpaid leave and often parents mix these forms in a very flexible way. Therefore, multiple methodological issues arise regarding how to most accurately measure leave length. The purpose of this paper is to review the somewhat complex legislation and the possible ways of using parental leave before presenting a successful attempt of a more precise way of measuring leave lengths, including paid and unpaid days, for mothers and fathers.Design/methodology/approachThe study makes use of administrative data for a complete cohort of parents of first born children in 2009 in Sweden. The authors examine what characteristics are associated with the use of paid and unpaid leave for mothers and fathers during the first two years of the child’s life, focusing particularly on how individual and household income is associated with leave patterns.FindingsAmong mothers, low income is associated with many paid leave days whereas middle income is associated with most unpaid days. High income mothers use a shorter leave. Among fathers it is the both ends with high and low household income that uses most paid and unpaid leave.Practical implicationsA measure that includes unpaid parental leave will be important to not underestimate the parental leave and to prevent faulty comparisons between groups by gender and by socioeconomic status.Originality/valueA measure of parental leave including both paid and unpaid leave will also facilitate international comparisons of leave length.