bluuebunny/crossref_metadata_2025_split huggingface dataset:
A atuação da Univille no PET-Saúde/GraduaSUS
Authors: Magri Patricia Esther Fendrich , Paiano Helena Maria Antunes , Salin Mauren da Silva 
Published: December 2020

O PET- Saúde/GraduaSUS é um programa federal que propõe a aproximação dos cursos da área da saúde com o SUS para reorientação da formação profissional em serviço. Em 2015, os cursos de Educação Física, Odontologia, Farmácia, Psicologia, Enfermagem e Medicina da Univille em parceria com a Secretaria de Saúde/Joinville-SC, elaboraram e conquistaram a aprovação do projeto, cuja meta é implantar um componente curricular comum aos seis cursos. Objetivo: descrever as ações realizadas no Projeto PET-Saúde/GraduaSUS. Metodologia: Desde a aprovação, uma equipe de professores e profissionais da Secretaria de Saúde trabalham arduamente desenvolvendo uma proposta de implementação de um componente curricular que compreenda a atenção à saúde como uma prática interprofissional. As ações desenvolvidas para alcançar a meta se referem a estudos teóricos para definição de concepções de formação e trabalho interprofissional, práticas colaborativas e clínica ampliada; reuniões com os coordenadores de cursos, tanto quanto uma prática considerada piloto, na qual estudantes de graduação, profissionais de saúde e professores da universidade experimentam a ideia principal da proposta que é estar nas Unidades Básicas de Saúde (UBS), em grupos, experimentando a educação interprofissional em benefício da formação para atuar na promoção da saúde dos usuários do SUS. O principal resultado é a implantação do componente obrigatório Práticas Interprofissionais em Saúde a partir de 2018 nos cursos de Educação Física e Odontologia. Os estudantes irão compor turmas mistas com atividades na universidade, nas UBS e realizarão diagnóstico da realidade, planejamento e intervenções sob a supervisão de professores e preceptores. Conclusão: Embora se reconheça que o trabalho em equipe exige persistência e vontade de inovar, a meta do projeto está em processo de consolidação. Durante a caminhada muitos obstáculos tiveram que ser transpostos, porém com determinação, foco e liderança o componente está consolidado e no próximo ano poderemos relatar os resultados do componente.
EFFECTS OF ZIZIPHUS JUJUBE SUPPLEMENTATION ON PRO- AND ANTI-APOPTOTIC PROTEIN EXPRESSION IN NEUTROPHILS AFTER RESISTANCE EXERCISE
Authors: Tayebi S , Krüger K , Safakar M , Bahrami P , Tahmasb G , Nenasheva A 
Published: December 2020

Introduction. It is suggested that jujube might have beneficial effects on exercise-induced immune perturbations, specifically on neutrophils apoptosis regulation, but its cellular mechanism is unclear. Aim. The aim of this study was to investigate the acute effect of Ziziphus jujuba administration on pro- and anti-apoptotic protein levels in human neutrophils in response to a session of circuit resistance exercise (Ex). Material and Methods. Participants completed an Ex (75 % 1RM, 9 exercises, 3 sets). While one group received a placebo, the other group (Zj) was supplemented daily with jujube (0.5 gr/kg body weight suspended in 2.5cc distilled water) one hour before Ex. Results. Ex increased the neutrophil level of [Ca2+]i, calpain-1 and caspase-3 (p < 0.05) while a reduction of calpastatin and XIAP were observed (p < 0.05). Zj either suppressed the [Ca2+]i or reversed the calpastatin, calpain-1, XIAP, and caspase-3 responses (p < 0.01). Conclusions. The data indicate that a single session of intensive Ex induced apoptotic signaling in human neutrophils with the involvement of [Ca2+]i-calpastatin-calpain axis upstream caspase-3. Acute administration of jujube solution before exercise attenuated these effects probably by providing energy sources for neutrophils or by functioning as antioxidants.
FORMATION OF RATIONAL RHYTHMIC STRUCTURE OF RUNNING IN COMPETITIVE DISCIPLINES OF FIRE AND RESCUE SPORTS
Authors: Germanov G , Korolkov A , Shalaginov V 
Published: December 2020

Aim. The paper aims to develop a methodology for a rational rhythmic structure of running in the competitive disciplines of fire and rescue sports. Materials and methods. The study involved athletes (Candidates for Master of Sport, Masters of Sport). Twenty-four people participated in the pedagogical experiment. The dynamics of the results of about 100 athletes of both sexes was analyzed. In total, over 300 races in the competitive disciplines of fire and rescue sports were included in the study. The following methods were used: video recording, electrical timekeeping; psychophysical testing (tapping test; Flamingo test, Fukuda walking test, Yarotsky test); pedagogical experiment, methods of mathematical statistics. Results. The method of formation of rational rhythmic structure of running in competitive disciplines of fire and rescue sports was developed. This method leads to minimizing errors, improving motor reliability and achieving high quantity and quality competitive results. Conclusions. The method of formation of rational rhythmic structure of running improves competitive results, provides performance enhancement in competitive disciplines of fire and rescue sports, promotes improvement of physical fitness and is suitable for both fire rescue workers and female athletes.
Endogenous Cholinergic Signaling Modulates Sound-Evoked Responses of the Medial Nucleus of the Trapezoid Body
Authors: Zhang Chao , Beebe Nichole L. , Schofield Brett R. , Pecka Michael , Burger R. Michael 
Published: December 2020

The medial nucleus of trapezoid body (MNTB) is a major source of inhibition in auditory brainstem circuitry. The MNTB projects well-timed inhibitory output to principal sound-localization nuclei in the superior olive (SOC) as well as other computationally important centers. Acoustic information is conveyed to MNTB neurons through a single calyx of Held excitatory synapse arising from the cochlear nucleus. The encoding efficacy of this large synapse depends on its activity rate, which is primarily determined by sound intensity and stimulus frequency. However, MNTB activity rate is additionally influenced by inhibition and possibly neuromodulatory inputs, albeit their functional role is unclear. Happe and Morley (2004) discovered prominent expression of α7 nAChRs in rat SOC, suggesting possible engagement of ACh-mediated modulation of neural activity in the MNTB. However, the existence and nature of this putative modulation have never been physiologically demonstrated. We probed nicotinic cholinergic influences on acoustic responses of MNTB neurons from adult gerbils (Meriones unguiculatus) of either sex. We recorded tone-evoked MNTB single-neuron activityin vivousing extracellular single-unit recording. Piggyback multibarrel electrodes enabled pharmacological manipulation of nAChRs by reversibly applying antagonists to two receptor types, α7 and α4β2. We observed that tone-evoked responses are dependent on ACh modulation by both nAChR subtypes. Spontaneous activity was not affected by antagonist application. Functionally, we demonstrate that ACh contributes to sustaining high discharge rates and enhances signal encoding efficacy. Additionally, we report anatomic evidence revealing novel cholinergic projections to MNTB arising from pontine and superior olivary nuclei.SIGNIFICANCE STATEMENTThis study is the first to physiologically probe how acetylcholine, a pervasive neuromodulator in the brain, influences the encoding of acoustic information by the medial nucleus of trapezoid body, the most prominent source of inhibition in brainstem sound-localization circuitry. We demonstrate that this cholinergic input enhances neural discrimination of tones from noise stimuli, which may contribute to processing important acoustic signals, such as speech. Additionally, we describe novel anatomic projections providing cholinergic input to the MNTB. Together, these findings shed new light on the contribution of neuromodulation to fundamental computational processes in auditory brainstem circuitry and to a more holistic understanding of modulatory influences in sensory processing.
Transition of young adults with endocrine and metabolic diseases: the ‘TRANSEND’ cohort
Authors: Le Roux Enora , Menesguen Florence , Tejedor Isabelle , Popelier Marc , Halbron Marine , Faucher Pauline , Malivoir Sabine , Pinto Graziella , Léger Juliane , Hatem Stephane , Polak Michel , Poitou Christine , Touraine Philippe 
Published: December 2020

Objective
The transition from paediatric to adult medicine involves risks of poor patient outcomes and of significant losses of patients to follow up. The research aimed to analyse the implementation in an initial cohort of patients of a new programme of transition to adult care based on a case management approach.

Design
A longitudinal study of the case management approach to transition, initiated in a university hospital in France in September 2016.

Methods
Patients with the endocrine or metabolic disease diagnosed during childhood and transferred to adult care were included. The transition programme includes three steps based on case management: liaising with paediatric services, personalising care pathways, and liaising with structures outside the hospital (general practitioners, agencies in the educational and social sector).

Results
The cohort included 500 patients, with malignant brain tumour (n = 56 (11%)), obesity (n = 55 (11%)), type 1 diabetes (n = 54 (11%)), or other disease (n = 335 (67%)). Their median age at transfer was 19, and the sex ratio was 0.5. At median 21 months of follow-up, 439 (88%) had a regular follow-up in or outside the hospital, 47 (9%) had irregular follow-up (absence at the last appointment or no appointment scheduled within the time recommended), 4 had stopped care on doctor’s advice, 4 had died, 3 had moved, and 3 had refused care. The programme involved 9615 case management actions; 7% of patients required more than 50 actions. Patients requiring most support were usually those affected by a rare genetic form of obesity.

Conclusions
Case managers successfully addressed the complex needs of patients. Over time, the cohort will provide unprecedented long-term outcome results for patients with various conditions who experienced this form of transition.
Cytokine concentrations direct endothelial function in pregnancy and preeclampsia
Authors: Mauro Amanda K , Khurshid Nauman , Berdahl Danielle M , Ampey Amanda C , Adu Daniel , Shah Dinesh M , Boeldt Derek S 
Published: December 2020

Abstract
Endothelial dysfunction is a prominent feature of preeclampsia, a hypertensive disorder of pregnancy, and contributes to multiple symptoms characteristic of the syndrome. A myriad of growth factors and cytokines are dysregulated in preeclampsia as compared to normal pregnancy, however, a complete appreciation of the effect of changing concentrations of these factors on endothelial function is lacking. In this study, we evaluate the effect of a variety of growth factors and cytokines on Ca2+ signaling and monolayer integrity. We report that VEGF165, TNFα, EGF, and IL-1β either improve or inhibit Ca2+ signaling depending on dose, whereas TNFα and IL-1β reduce monolayer integrity and bFGF increases monolayer integrity. Additionally, to model the effects of combinations of growth factors and cytokines, we screened for Ca2+ signaling changes in response to 16 dose combinations of VEGF165 and TNFα together. This revealed an optimal combination capable of supporting pregnancy-adapted Ca2+ signaling, and that changes in either VEGF165 or TNFα dose would result in a shift toward suppressed function. This study shows in detail how growth factor or cytokine concentration effects endothelial cell function. Such data can be used to model how changing growth factor and cytokine levels in normal pregnancy may contribute to healthy endothelial function and in preeclampsia may promote endothelial dysfunction. The results of VEGF165 and TNFα combination treatments suggest that more complex growth factor and cytokine combination modeling may be important in order to more accurately understand the effects of circulating factors on the endothelial function.
Estabilidad de Taludes del Tajo Abierto Jésica considerando el Macizo Rocoso Isotrópico y Anisotrópico
Authors: Herrera Carranza Editta , Solórzano Poma Lloyd Williams 
Published: December 2020

El trabajo de investigación analiza la estabilidad del talud global, en seis (6) tipos de alteración hidrotermal presentes en el tajo abierto Jésica, considerando al macizo rocoso isotrópico es decir que no tiene orientación preferencial de discontinuidades y anisotrópico teniendo en cuenta las discontinuidades paralelas o subparalelas al talud. Para el análisis de estabilidad de taludes del macizo rocoso isotrópico y anisotrópico se utilizó el criterio de rotura de Hoek-Brown Generalizado y Anisotrópico Generalizado respectivamente, ambos en el software Slide versión 6.0.
En el análisis de estabilidad anisotrópico se consideraron dos (2) familias de discontinuidades subparalelas al talud F1 (buzamiento de 72° a 82°) y F2 (buzamiento de 45° a 55°). Los factores de seguridad obtenidos considerando el macizo rocoso anisotrópico son menores hasta en 29% respecto a los obtenidos en el macizo rocoso isotrópico; así mismo a mayor calidad del macizo rocoso, mayor es la variación de los factores de seguridad, esta diferencia es más marcada en la zona de sulfuros con la familia F2, donde en un macizo rocoso con RMR 40 el factor de seguridad disminuye en 8%, mientras que en un macizo rocoso con RMR 61 el factor de seguridad disminuye en 29%.
Overcoming Vanitas, or Showing One’s Cards
Authors: Kubeckienė Vaiva 
Published: December 2020

In the article the painting Card Player Showing His Hand by T. Rombouts (17th c. Netherlands) is being interpreted. It is noticed that two existential manifestations may interact in this composition: the gambler’s and Vanitas. In the first part of this article, an analysis is made how Rombouts presents card play as a way of being and how he integrates it into the genre of Vanitas. In the second part the hypothesis, is it proven that the composition of the painting continues the theme of Vanitas and questions it at the same time.
Los problemas de esbeltez en el diseño de columnas de concreto
Authors: Aycardi Luis Guillermo 
Published: December 2020

El presente es el primero de una serie de artículos en los cuales se pretende estudiar los problemas de segundo orden en el diseño de columnas, la razón de las expresiones que proponen los reglamentos, y de paso los problemas de inestabilidad estructural de pórticos y estructuras elementales.
Algorithm and Technical Solutions for Dynamic Configuration of Client-Server Computing Networks
Authors: Maximov Roman , Sokolovsky Sergey , Voronchikhin Ivan 
Published: December 2020

The main factors that determine the expansion of capabilities and increase the effectiveness of network intelligence to identify the composition and structure of client-server computer networks due to the stationarity of their structural and functional characteristics are analyzed. The substantiation of an urgent problem of dynamic management of structurally-functional characteristics of the client-server computer networks functioning in the conditions of network reconnaissance is resulted on the grounds of the revealed protection features of client-server computer networks at the present stage that is based on realization of principles of spatial safety maintenance, and also formalization and introduction of forbidding regulations.
The mathematical model allowing to find optimum modes for dynamic configuration of structurally-functional characteristics of client-server computer networks for various situations is presented. Calculation results are given. An algorithm is presented that makes it possible to solve the problem of dynamic configuration of the structural and functional characteristics of a client-server computer network, which reduces the reliability time of data obtained by network intelligence. The results of practical tests of software developed on the basis of the dynamic configuration algorithm of client-server computer networks are shown. The obtained results show that the use of the presented solution for the dynamic configuration of client-server computer networks allows to increase the effectiveness of protection by changing the structural and functional characteristics of client-server computer networks within several subnets without breaking critical connections through time intervals that are adaptively changed depending on the functioning conditions and the attacker’s actions.
The novelty of the developed model lies in the application of the mathematical apparatus of the Markov’s theory of random processes and Kolmogorov’s solution of equations to justify the choice of dynamic configuration modes for the structural and functional characteristics of client-server computer networks. The novelty of the developed algorithm is the use of a dynamic configuration model for the structural and functional characteristics of client-server computer networks for the dynamic control of the structural and functional characteristics of a client-server computer network in network intelligence.
The Iranian Seismological Center’s Performance during the COVID-19 Pandemic and after the Occurrence of Large Earthquakes
Authors: Naserieh Saeid , Karkooti Ehsan , Rahmati Mehdi , Dezvareh Mohsen , Roohi Iraj 
Published: December 2020

Abstract
The COVID-19 pandemic is an ongoing global health emergency that has overshadowed almost all aspects of human life in most of the world. The seismic monitoring centers are a crucial component of the earthquake crisis management, and continuity of their operations during different crises is critical. Occurrence of any unusual condition (such as COVID-19 crisis) could result in failures in detecting seismic events.
This article aims to share the experiences at the Iranian Seismological Center (IRSC) in 2020 during the first months of the COVID-19 epidemic: how the monitoring changed in comparison with the routine surveillance system. One of the main impacts of the pandemic was loss of active stations due to a halt in routine maintenance visits to the seismic stations. The restrictions imposed by the government to contain the virus resulted in loss of 8% of the stations of IRSC network. We analyze how seismic noise changed during the lockdown. The results show that unlike many other places in the world, Iran did not see a seismic noise reduction during the lockdowns from the pandemic. In addition, we describe the response of IRSC following large earthquakes. The increase in workload after big earthquakes is discussed and some lessons from these crises are shared. The need to update seismic monitoring software to allow for some automatic processing and to carefully revise the processing routines to balance the workload during large earthquakes is discussed. Also, re-evaluation of seismic station locations for better maintenance access could lead to fewer problems at the time of crisis like the current pandemic.
Skinner: Sobre o Reducionismo
Authors: Ramos Jefferson Pessôa , Teixeira Luan Mendes , Barbosa João Ilo Coelho 
Published: December 2020

O problema do reducionismo é uma questão perene na história e na filosofia da ciência. Tendo em vista a polissemia do termo e dos problemas advindos de se nomear um autor ou uma corrente teórica em ciência como reducionista, buscou-se neste ensaio teórico avaliar a que tipos de proposições reducionistas o pensamento skinneriano se opõe e/ou das quais se aproxima, com a finalidade de buscar reduzir equívocos no emprego desse adjetivo ao pensamento de B. F. Skinner. Para tanto, foi realizada uma análise conceitual de sua extensa obra de caráter teórico, no que se refere à possibilidade de ser categorizada como reducionista. Com exceção do período anterior à publicação do primeiro livro de Skinner em 1938, foram encontradas três categorias de reducionismo discutidas na obra skinneriana. Em uma primeira acepção, Skinner posiciona-se contra o reducionismo de condução derivacional, na segunda, coloca-se contra o reducionismo como uma supersimplificação dos fenômenos comportamentais e, por fim, apresentou-se uma terceira função para o debate ao identificá-lo como um defensor do estatuto nomológico do comportamento. Conclui-se que atribuir o rótulo de reducionista ao pensamento de Skinner não se configura um equívoco, pois esta ideia pode variar em função de que tipo de reducionismo está em questão. Apenas um dos três sentidos do termo reducionismo, o qual se refere a este como uma defesa do estatuto nomológico do comportamento, é concordante com o pensamento de Skinner. Os outros dois sentidos, o de condução derivacional e o de supersimplificação, podem ser considerados incompatíveis com a proposta skinneriana de ciência.Palavras-chave: análise do comportamento; Skinner; reducionismo; redução; análise conceitual.
Ensino de Pais via Telessaúde para a Implementação de Procedimentos Baseados em ABA: Uma Revisão de Literatura e Recomendações em Tempos de COVID-19
Authors: Carneiro Anne Caroline da Costa , Brassolatti Isabella Marino , Nunes Luyse França Silva , Damasceno Fernanda Câmara Alves , Cortez Mariéle Diniz 
Published: December 2020

Por ocasião da pandemia de COVID-19, muitos profissionais precisaram adaptar seus atendimentos a crianças com Transtorno do Espectro Autista (TEA) para a via remota (telessaúde), além de inserir os pais na terapia. A presente revisão de literatura fornece (1) uma síntese atualizada das pesquisas empíricas sobre ensino de pais, via telessaúde, para implementação de procedimentos baseados em ABA e (2) uma análise detalhada das características das famílias. Primeiramente, foi realizada uma análise dos artigos incluídos em uma revisão sistemática da literatura sobre telessaúde publicada em 2020 para identificar os estudos que tiveram como participantes apenas pais/mães e seus respectivos filhos (n=17). Em seguida, foi realizada uma busca sistemática em quatro bases de dados de artigos sobre ensino de pais via telessaúde (abril de 2019 a abril de 2020) para atualizar a revisão de literatura sobre a temática (n=6). Os resultados apontaram que a modalidade de telessaúde tem se mostrado uma alternativa viável e efetiva, a um custo reduzido. No entanto, observa-se escassez de informações relativas às características dos participantes. Com base nos resultados e nas informações apresentadas nos artigos analisados, foram elaboradas recomendações que poderão ser úteis na implementação de procedimentos baseados em ABA via telessaúde, durante e após a pandemia de COVID-19.Palavras-chave: telessaúde; ensino de pais; ABA; revisão de literatura; autismo.
A CONFLITUOSA RELAÇÃO DE ALFREDO COM A EDUCAÇÃO E O LUGAR: REPRESENTAÇÃO NA OBRA CHOVE NOS CAMPOS DE CACHOEIRA
Authors: LIMA Maria do Socorro Pereira 
Published: December 2020

Este artigo tem como objetivo fazer uma discussão sobre a conflituosa relação do personagem infantil Alfredo com a educação e a Vila de Cachoeira, representadas na obra Chove nos Campos de Cachoeira, de Dalcídio Jurandir. A pesquisa é histórica e tem como principal fonte a literatura da Amazônia. A discussão teórica conta com os estudos de Roger Chartier e Walter Benjamin. Concluímos que pelo viés da percepção literária e poder criador, o olhar crítico do personagem Alfredo em relação à educação e ao lugar demarca uma total falta de identidade com a realidade de Vila de Cachoeira, por não vê neste lugar uma perspectiva de futuro, ocasionada pelo abandono do poder público, pelos métodos ultrapassados de ensino. Considerando estes pontos, o personagem começa a planejar sua fuga na certeza de constituir uma nova identidade num outro lugar. Palavras-chave: Representação de Educação. Conflitos Identitários. Experiências Literárias. Literatura da Amazônia.