bluuebunny/crossref_metadata_2025_split huggingface dataset:
The permanent ellipticity of the neutron star in PSR J1023+0038
Authors: Bhattacharyya Sudip 
Published: July 2020

ABSTRACT
A millisecond pulsar having an ellipticity, which is an asymmetric mass distribution around its spin-axis, could emit continuous gravitational waves, which have not been detected so far. An indirect way to infer such waves is to estimate the contribution of the waves to the spin-down rate of the pulsar. The transitional pulsar PSR J1023+0038 is ideal and unique for this purpose because this is the only millisecond pulsar for which the spin-down rate has been measured in both accreting and non-accreting states. Here, we infer, from our formalism based on the complete torque budget equations and the pulsar magnetospheric origin of observed γ-rays in the two states, that PSR J1023+0038 should emit gravitational waves due to a permanent ellipticity of the pulsar. The formalism also explains some other main observational aspects of this source in a self-consistent way. As an example, our formalism naturally infers the accretion disc penetration into the pulsar magnetosphere, and explains the observed X-ray pulsations in the accreting state using the standard and well-accepted scenario. This, in turn, infers the larger pulsar spin-down power in the accreting state, which, in our formalism, explains the observed larger γ-ray emission in this state. Exploring wide ranges of parameter values of PSR J1023+0038, and not assuming an additional source of stellar ellipticity in the accreting state, we find the misaligned mass quadrupole moment of the pulsar in the range of (0.92–1.88) × 1036 g cm2, implying an ellipticity range of (0.48–0.93) × 10−9.
Resistome analysis of bloodstream infection bacterial genomes reveals a specific set of proteins involved in antibiotic resistance and drug efflux
Authors: Oliveira Willian K , Ferrarini Mariana , Morello Luis G , Faoro Helisson 
Published: July 2020

Abstract
Bacterial resistance to antibiotics is a global public health problem. Its association with bloodstream infections is even more severe and may easily evolve to sepsis. To improve our response to these bacteria, it is essential to gather thorough knowledge on the main pathogens along with the main mechanisms of resistance they carry. In this paper, we performed a large meta-analysis of 3872 bacterial genomes isolated from blood samples, from which we identified 71 745 antibiotic resistance genes (ARGs). Taxonomic analysis showed that Proteobacteria and Firmicutes phyla, and the species Klebsiella pneumoniae and Staphylococcus aureus were the most represented. Comparison of ARGs with the Resfams database showed that the main mechanism of antibiotic resistance is mediated by efflux pumps. Clustering analysis between resistome of blood and soil-isolated bacteria showed that there is low identity between transport and efflux proteins between bacteria from these environments. Furthermore, a correlation analysis among all features showed that K. pneumoniae and S. aureus formed two well-defined clusters related to the resistance mechanisms, proteins and antibiotics. A retrospective analysis has shown that the average number of ARGs per genome has gradually increased. The results demonstrate the importance of comprehensive studies to understand the antibiotic resistance phenomenon.
Immune effector cell–associated neurotoxicity syndrome after chimeric antigen receptor T-cell therapy for lymphoma: predictive biomarkers and clinical outcomes
Authors: Holtzman Noa G , Xie Hao , Bentzen Soren , Kesari Vivek , Bukhari Ali , El Chaer Firas , Lutfi Forat , Siglin Jonathan , Hutnick Elizabeth , Gahres Natalie , Ruehle Kathleen , Ahmad Haroon , Shanholtz Carl , Kocoglu Mehmet H , Badros Ashraf Z , Yared Jean A , Hardy Nancy M , Rapoport Aaron P , Dahiya Saurabh 
Published: July 2020

AbstractBackgroundCD19-directed chimeric antigen receptor (CAR) T-cell therapy (CAR-T) has emerged as effective for relapsed/refractory large B-cell lymphoma (R/R LBCL). The neurologic toxicity seen with CAR-T, referred to as immune effector cell–associated neurotoxicity syndrome (ICANS), is poorly understood. To better elucidate the clinical characteristics, treatment outcomes, and correlative biomarkers of ICANS, we review here a single-center analysis of ICANS after CAR T-cell therapy in R/R LBCL.MethodsPatients (n = 45) with R/R LBCL treated with axicabtagene ciloleucel (axi-cel) were identified. Data regarding treatment course, clinical outcomes, and correlative studies were collected. Patients were monitored and graded for ICANS via CARTOX-10 scoring and Common Terminology Criteria for Adverse Events (CTCAE) v4.03 criteria, respectively.ResultsTwenty-five (56%) patients developed ICANS, 18 (72%) of whom had severe (CTCAE grades 3–4) ICANS. Median time to development of ICANS was 5 days (range, 3–11). Elevated pre-infusion (day 0 [D0]) fibrinogen (517 vs 403 mg/dL, upper limit of normal [ULN] 438 mg/dL, P = 0.01) and D0 lactate dehydrogenase (618 vs 506 units/L, ULN 618 units/L, P = 0.04) were associated with ICANS. A larger drop in fibrinogen was associated with ICANS (393 vs 200, P &lt; 0.01). Development of ICANS of any grade had no effect on complete remission (CR), progression-free survival (PFS), or overall survival (OS). Duration and total dose of steroid treatment administered for ICANS did not influence CR, PFS, or OS.ConclusionsICANS after CAR-T with axi-cel for R/R LBCL was seen in about half of patients, the majority of which were high grade. Contrary to previous reports, neither development of ICANS nor its treatment were associated with inferior CR, PFS, or OS. The novel finding of high D0 fibrinogen level can identify patients at higher risk for ICANS.
Characterization of Magnetic Resonance Thermal Imaging Signal Artifact During Magnetic Resonance Guided Laser-Induced Thermal Therapy
Authors: Munier Sean M , Liang Allison S , Desai Akshay N , James Jose K , Danish Shabbar F 
Published: July 2020

Abstract

BACKGROUND
Magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) is a minimally invasive procedure that utilizes intraoperative magnetic resonance thermal imaging (MRTI) to generate a thermal damage estimate (TDE) of the ablative area. In select cases, the MRTI contains a signal artifact or defect that distorts the ablative region. No study has attempted to characterize this artifact.

OBJECTIVE
To characterize MRTI signal the artifact in select cases to better understand its potential relevance and impact on the ablation procedure.

METHODS
All ablations were performed using the Visualase magnetic resonance imaging-guided laser ablation system (Medtronic). Patients were included if the MRTI contained signal artifact that distorted the ablative region during the first thermal dose delivered. Ablation artifact was quantified using MATLAB version R2018a (Mathworks Inc, Natick, Massachusetts).

RESULTS
A total of 116 patients undergoing MRgLITT for various surgical indications were examined. MRTI artifact was observed in 37.0% of cases overall. Incidence of artifact was greater at higher powers (P < .001) and with longer ablation times (P = .024), though artifact size did not correlate with laser power or ablation duration.

CONCLUSION
MRTI signal artifact is common during LITT. Higher powers and longer ablation times result in greater incidence of ablation artifact, though artifact size is not correlated with power or duration. Future studies should aim to evaluate effects of artifact on postoperative imaging and, most notably, patient outcomes.
Magnetic Resonance-Guided Focused Ultrasound Capsulotomy for Treatment-Resistant Psychiatric Disorders
Authors: Davidson Benjamin , Hamani Clement , Huang Yuexi , Jones Ryan M , Meng Ying , Giacobbe Peter , Lipsman Nir 
Published: July 2020

Abstract

BACKGROUND
Psychiatric surgery is an important domain of functional neurosurgery and involves deep brain stimulation (DBS) or lesional procedures performed for treatment-resistant psychiatric illness. It has recently become possible to use magnetic-guided focused ultrasound (MRgFUS) to perform bilateral capsulotomy, a lesional technique commonly carried out with surgical radiofrequency ablation or stereotactic radiosurgery. MRgFUS offers several advantages, including improved safety and real-time imaging of the lesions.

OBJECTIVE
To describe the clinical and technical aspects of performing bilateral MRgFUS capsulotomy in patients with severe refractory depression and obsessive-compulsive disorder.

METHODS
We describe the clinical and technical considerations of performing MRgFUS capsulotomy. Topics discussed include patient selection, headframe application, targeting, sonication strategies, and follow-up procedures.

RESULTS
MRgFUS capsulotomy was performed in 16 patients without serious clinical or radiographic adverse events.

CONCLUSION
MRgFUS allows for a safe, less invasive technique for performing a well-studied psychiatric surgery procedure—the anterior capsulotomy.
Super-Resolution Fluorescence Imaging of Arabidopsis thaliana Transfer Cell Wall Ingrowths using Pseudo-Schiff Labelling Adapted for the Use of Different Dyes
Authors: Rae Angus E , Wei Xiaoyang , Flores-Rodriguez Neftali , McCurdy David W , Collings David A 
Published: July 2020

AbstractTo understand plant growth and development, it is often necessary to investigate the organization of plant cells and plant cell walls. Plant cell walls are often fluorescently labeled for confocal imaging with the dye propidium iodide using a pseudo-Schiff reaction. This reaction binds free amine groups on dye molecules to aldehyde groups on cellulose that result from oxidation with periodic acid. We tested a range of fluorescent dyes carrying free amine groups for their ability to act as pseudo-Schiff reagents. Using the low-pH solution historically used for the Schiff reaction, these alternative dyes failed to label cell walls of Arabidopsis cotyledon vascular tissue as strongly as propidium iodide but replacing the acidic solution with water greatly improved fluorescence labeling. Under these conditions, rhodamine-123 provided improved staining of plant cell walls compared to propidium iodide. We also developed protocols for pseudo-Schiff labeling with ATTO 647N-amine, a dye compatible for super-resolution Stimulated Emission Depletion (STED) imaging. ATTO 647N-amine was used for super-resolution imaging of cell wall ingrowths that occur in phloem parenchyma transfer cells of Arabidopsis, structures whose small size is only slightly larger than the resolution limit of conventional confocal microscopy. Application of surface-rendering software demonstrated the increase in plasma membrane surface area as a consequence of wall ingrowth deposition and suggests that STED-based approaches will be useful for more detailed morphological analysis of wall ingrowth formation. These improvements in pseudo-Schiff labeling for conventional confocal microscopy and STED imaging will be broadly applicable for high-resolution imaging of plant cell walls.
Gibberellin Metabolism and Signaling: Targets for Improving Agronomic Performance of Crops
Authors: Gao Shaopei , Chu Chengcai 
Published: July 2020

AbstractGibberellins (GAs) are a class of tetracyclic diterpenoid phytohormones that regulate many aspects of plant development, including seed germination, stem elongation, leaf expansion, pollen maturation, and the development of flowers, fruits and seeds. During the past decades, the primary objective of crop breeding programs has been to increase productivity or yields. ‘Green Revolution’ genes that can produce semidwarf, high-yielding crops were identified as GA synthesis or response genes, confirming the value of research on GAs in improving crop productivity. The manipulation of GA status either by genetic alteration or by exogenous application of GA or GA biosynthesis inhibitors is often used to optimize plant growth and yields. In this review, we summarize the roles of GAs in major aspects of crop growth and development and present the possible targets for the fine-tuning of GA metabolism and signaling as a promising strategy for crop improvement.
Presidential Address. Far From Ordinary Questions: Task Difficulty, Motivation, and Measurement Practice
Authors: Schaeffer Nora Cate 
Published: July 2020

AbstractAs Howard Schuman noted in his presidential address in 1986, survey respondents expect to be asked “ordinary questions,” but our questions often make extraordinary demands. The impact of the difficult tasks we give to respondents on their motivation to provide complete and accurate information is an aspect of the infrastructure of measurement in surveys that has received little attention. When questions are particularly difficult for some groups in a target population, the comparability of measurement for all units in a population is reduced. For measurement to be comparable across all groups in a population, questions must be equally accessible—and equally motivating—to all. Some challenges to improving the practice of measurement in surveys arise because—under the constraints of limited time, budget, and staff—we borrow questions, give them authority based on their source, assert that we need to replicate them to make comparisons, and fail to fully examine claims that they have been validated. Although the constraints are real, these practices limit our ability to take full advantage of advances in research about instrument design to improve the quality of measurement in surveys.
Elastic Resistance Training Produces Benefits Similar to Conventional Resistance Training in People With Chronic Obstructive Pulmonary Disease: Systematic Review and Meta-Analysis
Authors: de Lima Fabiano F , Cavalheri Vinicius , Silva Bruna S A , Grigoletto Isis , Uzeloto Juliana S , Ramos Dionei , Camillo Carlos A , Ramos Ercy M C 
Published: July 2020

Abstract

Objective
The purpose of this study was to investigate the effectiveness of elastic resistance training on improving muscle strength, functional exercise capacity, health-related quality of life (HRQoL), and dyspnea in people with stable chronic obstructive pulmonary disease (COPD).

Methods
For this systematic review, PubMed, The Cochrane Library, Embase (OVID), PEDro, SciELO, and CINAHL were searched from inception to November 2019. Included studies were randomized clinical trials in which people with stable COPD were allocated to (1) an experimental group that received lower-limb resistance training, upper-limb resistance training, or both using elastic resistance; or (2) a control group that received no or sham resistance training or conventional resistance training using weight machines. Data extraction was performed by 3 review authors. The methodological quality of the studies was assessed using the PEDro scale. Eight studies on 332 participants were included.

Results
Knee extensor strength was higher in the experimental group (standardized mean difference = 0.52, 95% CI = 0.09–0.95) compared with the non-exercise control group. Compared with the conventional exercise control, the experimental group presented similar effects for muscle strength, functional exercise capacity, HRQoL, and dyspnea (95% CI overlapped the line of no effect for all).

Conclusions
Elastic resistance training improves muscle strength in people with COPD. The current review suggests elastic resistance as a potential alternative to conventional resistance training using weight machines, as they show similar effects on muscle strength, functional exercise capacity, HRQoL, and dyspnea.

Impact
Due to its beneficial effects, including reduced risk of exacerbation-related hospitalizations, exercise training is viewed as the cornerstone of pulmonary rehabilitation in people with COPD. This study shows that elastic resistance training can be an effective, portable, practical, and low-cost alternative to conventional weight resistance training.

Lay Summary
Training with elastic resistance tubes or bands—which are easy to carry, easy to use, and relatively low cost—can be an effective way to improve strength for people with COPD and promote similar benefits to those achieved with weight machines.
Manual Therapy Versus Surgery for Carpal Tunnel Syndrome: 4-Year Follow-Up From a Randomized Controlled Trial
Authors: Fernández-de-las-Peñas César , Arias-Buría José L , Cleland Joshua A , Pareja Juan A , Plaza-Manzano Gustavo , Ortega-Santiago Ricardo 
Published: July 2020

Abstract

Objective
No study to our knowledge has investigated the effects longer than 1 year of manual therapy in carpal tunnel syndrome (CTS). The purpose of this study was to investigate the effects of manual therapy versus surgery at 4-year follow-up and to compare the post-study surgery rate in CTS.

Methods
This randomized controlled trial was conducted in a tertiary public hospital and included 120 women with CTS who were randomly allocated to manual therapy or surgery. The participants received 3 sessions of physical therapy, including desensitization maneuvers of the central nervous system or carpal tunnel release combined with a tendon/nerve gliding exercise program at home. Primary outcome was pain intensity (mean and the worst pain). Secondary outcomes included functional status, symptom severity, and self-perceived improvement measured using a global rating of change scale. Outcomes for this analysis were assessed at baseline, 1 year, and 4 years. The rate of surgical intervention received by each group was assessed throughout the study.

Results
At 4 years, 97 (81%) women completed the study. Between-group changes for all outcomes were not significantly different at 1 year (mean pain: mean difference [MD] = −0.3, 95% CI = −0.9 to 0.3; worst pain: MD = −1.2, 95% CI = −3.6 to 1.2; function: MD = −0.1, 95% CI = −0.4 to 0.2; symptom severity: MD = −0.1, 95% CI = −0.3 to 0.1) and 4 years (mean pain: MD = 0.1, 95% CI = −0.2 to 0.4; worst pain: MD = 0.2, 95% CI = −0.8 to 1.2; function: MD = 0.1, 95% CI = −0.1 to 0.3; symptom severity: MD = 0.2, 95% CI = −0.2 to 0.6). Self-perceived improvement was also similar in both groups. No between-group differences (15% physical therapy vs 13% surgery) in surgery rate were observed during the 4 years.

Conclusions
In the long term, manual therapy, including desensitization maneuvers of the central nervous system, resulted in similar outcomes and similar surgery rates compared with surgery in women with CTS. Both interventions were combined with a tendon/nerve gliding exercise program at home.

Impact
This is the first study to our knowledge to report clinical outcomes and surgical rates during a 4-year follow-up and will inform decisions regarding surgical versus conservative management of CTS.

Lay summary
Women with CTS may receive similar benefit from a more conservative treatment—manual therapy—as they would from surgery.
Mortgage Securitization and Shadow Bank Lending
Authors: Gete Pedro , Reher Michael 
Published: July 2020

AbstractWe show how securitization affects the size of the nonbank lending sector through a novel price-based channel. We identify the channel using a regulatory spillover shock to the cross-section of mortgage-backed security prices: the U.S. liquidity coverage ratio. The shock increases secondary market prices for FHA-insured loans by granting them favorable regulatory status once securitized. Higher prices lower nonbanks’ funding costs, prompting them to loosen lending standards and originate more FHA-insured loans. This channel accounts for 22% of nonbanks’ growth in overall mortgage market share over 2013–2015. While the shock creates risks for financial stability, homeownership also increases.
Predicting treatment response to IL6R blockers in rheumatoid arthritis
Authors: Nouri Bako , Nair Nisha , Barton Anne 
Published: July 2020

AbstractPatients with severe, active RA who have not responded to conventional therapy may receive biological disease modifying anti-rheumatic drugs (bDMARDs). However, 40% of cases do not achieve complete disease control, resulting in a negative impact on patient quality of life and representing a waste of healthcare resources. Ongoing research seeks to establish biomarkers, which can be used to predict treatment response to biologics in RA to enable more targeted approaches to treatment. However, much of the work has focused on one class of biologic drug, the TNF inhibitors (TNFi). Here, we will review the current state of research to identify biomarkers predictive of response to the class of bDMARDs targeting the IL6R. While success has been limited thus far, serum drug and low ICAM1 levels have shown promise, with associations reported in independent studies. The challenges faced by researchers and lessons learned from studies of TNFi will be discussed.
Financialization and income generation in the 21st century: rise of the petit rentier class?
Authors: Goldstein Adam , Tian Ziyao 
Published: July 2020

Abstract
This article considers the consequences of asset-based accumulation for household income factors and social class structure in 29 countries from 1998 to 2016. Are financialization, asset-based welfare institutions, and rising real estate returns fueling a growing class of petit rentiers in capitalist economies? That is, households who accrue more than a trivial share of income from capital rather than labor or government transfers. The analysis draws on the Luxembourg Income Study data. Contrary to expectations, most countries saw declines in the share of households who accrue more than 10%, or 20% of income from assets. Estimates from correlated random effects models indicate that financialization is associated with between-country differences in the size of the petit rentier, but not within-country change over time. The decline of the petit rentier can be partly explained by declining interest rates, which reduces income from bank savings.
The Usual, Racialized, Suspects: The Consequence of Police Contacts with Black and White Youth on Adult Arrest
Authors: McGlynn-Wright Anne , Crutchfield Robert D , Skinner Martie L , Haggerty Kevin P 
Published: July 2020

AbstractResearch on race and policing indicates that Black Americans experience a greater frequency of police contacts, discretionary stops, and police harassment when stops occur. Yet, studies examining the long-term consequences of police contact with young people have not examined whether criminal justice consequences of police contact differ by race. We address this issue by examining whether police encounters with children and adolescents predict arrest in young adulthood and if these effects are the same for Black and White individuals. The paper uses longitudinal survey data from 331 Black and White respondents enrolled in the Seattle Public School District as eighth graders in 2001 and 2002. Our findings indicate that police encounters in childhood increase the risk of arrest in young adulthood for Black but not White respondents. Black respondents who experience contact with the police by the eighth grade have eleven times greater odds of being arrested when they are 20 years old than their White counterparts.