bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coping with distress among adolescents: Effectiveness of personal narratives on support websites
Authors: Mariën Sofie , Vandebosch Heidi , Pabian Sara , Poels Karolien 
Published: December 2020

Sharing, reading and responding to personal narratives on peer-to-peer support websites may provide adolescents with informational and emotional support to feel more confident in coping with stressful events. However, their use may also pose a threat to adolescents’ coping self-efficacy. Principles of expressive writing, social sharing of emotions, narrative persuasion and self-effects may provide insight in how these actions may both positively and negatively relate to coping self-efficacy. By using a cross-sectional online survey with 311 Dutch-speaking adolescents between the ages of 14 and 18, this article explores how these actions and social support motives (i.e. information-seeking and emotional support-seeking) are related to adolescents’ perceptions about the usefulness of these websites to their coping self-efficacy. The results showed a positive relation between adolescents’ social support motives and their belief in the usefulness of these websites to their coping self-efficacy. Therefore, we conclude that it may be an effective coping strategy for many adolescents. There was a negative relation between experience with sharing a personal narrative and coping self-efficacy, meaning that these users did not perceive the website to be helpful to their overall confidence in coping with stressful events. However, this negative relation was reversed when they were motivated to find emotional support with similar others.
Compartir, leer y responder a narraciones personales en webs de apoyo entre iguales puede tanto fortalecer como amenazar la confianza de los adolescentes para hacer frente a los acontecimientos estresantes (es decir, la autoeficacia como estrategia de afrontamiento). Los principios de la escritura expresiva, el intercambio social de emociones, la persuasión narrativa y los efectos en uno mismo pueden proporcionar información sobre la forma en que esas acciones pueden relacionarse con la autoeficacia como estrategia de afrontamiento. Mediante una encuesta transversal en línea con 311 adolescentes de habla holandesa de entre 14 y 18 años, este artículo explora cómo estas acciones y los motivos del apoyo social (es decir, la búsqueda de información y la búsqueda de apoyo emocional) se relacionan con la autoeficacia de los adolescentes como estrategia de afrontamiento tras usar la web de apoyo entre iguales. Los resultados muestran que la experiencia de los usuarios al leer y responder a narraciones personales no estaba relacionada con su autoeficacia de afrontamiento. Sin embargo, se encontró una relación negativa entre la experiencia de compartir una narración personal y la autoeficacia, por lo que los usuarios no percibieron que el sitio web fuera útil para su confianza general a la hora de hacer frente a acontecimientos estresantes. No obstante, esta relación negativa se invirtió cuando también tenían el objetivo de encontrar apoyo emocional con sus iguales.
Newsgames against hate speech in the refugee crisis
Authors: Gómez-García Salvador , Paz-Rebollo María-Antonia , Cabeza-San-Deogracias José 
Published: December 2020

The refugee crisis has been a fertile ground for hate speech that has portrayed migrants as a dangerous threat and has been spread through social networks. While the media have unconsciously contributed to the proliferation of these racist messages, some have reacted by extending their traditional journalistic activity to the creation of newsgames to find new ways of addressing the situation. This study examines the use of five newsgames developed by leading media outlets using a methodology based on a multimodal qualitative analysis (informative and ludonarrative). The results showed that newsgames players have access to truthful information, as is the case for other journalistic genres, and draw on other types of personal and emotional information (circumstances, feelings, family ties). These data did not appear in isolation but integrated into the gaming experience. The study concludes by identifying the interaction between the levels of information and immersion of the newsgames that make up the sample, as well as their different gradation: giving the player the opportunity to make more significant decisions within the story allows for the introduction of nuances that promote empathy towards refugees; however, greater freedom in the gaming experience in newsgames distances them from the classic informational model and may involve a greater risk of distortion of the ideas that they seek to promote.
La crisis de los refugiados ha sido el caldo de cultivo para unos discursos del odio, extendidos a través de las redes sociales, que presentan a los inmigrantes como un peligro y una amenaza. Los medios de comunicación han contribuido inconscientemente a su difusión, aunque algunos han reaccionado ampliando su actividad periodística tradicional a la creación de newsgames para buscar nuevas formas de contrarrestar el efecto de estos discursos. Esta investigación analiza cinco newsgames desarrollados por medios de comunicación de referencia a partir de una metodología basada en un análisis multimodal de carácter cualitativo (informativo y ludo-narrativo). Los resultados muestran que el jugador de newsgames tiene acceso a información veraz, como en otros formatos periodísticos, pero también dispone de otro tipo de información más próxima y emocional (circunstancias, sentimientos, vínculos familiares). Estos datos no aparecen de forma aislada, sino que se integran en la experiencia del juego. La investigación concluye identificando la interacción entre información e inmersión de los newsgames que componen la muestra, así como su diferente gradación: un mayor control del jugador dentro de la historia permite introducir matices que favorecen la empatía con los refugiados. Sin embargo, la mayor libertad en la experiencia de juego en los newsgames los aleja del modelo informativo clásico y puede implicar un mayor riesgo de distorsión de las ideas que intentan defender.
Does Neoadjuvant Chemotherapy Increase the Survival in Patients with Locally Advanced Gastric Cancer Patients? – A Real‑World Evidence
Authors: Janarthinakani Murugesan , Kalaiselvi Selvaraj , Priyadarshini Rajamani , Arun Seshachalam , Shashidhar K , Krishnakumar R , Manjunath N , Roopa Sirigeri , Raman SG 
Published: December 2020

Abstract
Background: In locally advanced gastric cancer (LAGC), perioperative chemotherapy has shown to improve the survival to a larger extent compared to surgery alone. In India, the treatment followed for gastric carcinoma widely varies based on the type of health-care provider and treatment access. There is a paucity of data on the role of neoadjuvant chemotherapy on survival among LAGC patients in the Indian context. Aim: The aim of this study was to compare the disease-free survival (DFS) and overall survival (OS) between neoadjuvant and adjuvant chemotherapies among LAGC patients. Subjects and Methods: This was a retrospective cohort study involving clinical record review of LAGC patients enrolled between 2015 and 2017 from four tertiary cancer centers in South India. The date for the following events, namely diagnosis, recurrence, death, and last day of visit, was extracted in a mobile-based open-access tool. The median duration of OS and DFS between the neoadjuvant and adjuvant groups was compared using Kaplan–Meier survival curves. Results: Of the 137 patients, 70 (51%) had received neoadjuvant chemotherapy followed by surgery and 67 (49%) had adjuvant chemotherapy following the surgery. The mean (standard deviation) age of participants was 55.4 (11.4) years. Seventy-eight percent of the patients were diagnosed at Stage 3 or 4. Regional lymph nodes were involved in 83.9%. The median duration of follow-up was 15 months. The OS in the neoadjuvant and adjuvant groups was 18.6 months and 8.3 months, respectively. Nonregional lymph node involvement and adjacent organ involvement had independently increased the risk of death. Conclusion: Among LAGC patients, the neoadjuvant chemotherapy indicated a better median and DFS compared to the adjuvant group. However, these findings were statistically not significant. The current study has contributed an important finding to the existing evidences of clinical practice in an Indian setting. Further large-scale studies are required to validate the promising trend of using neoadjuvant chemotherapy in LAGC.
Efficacy of Antiemetic Regimens for Prevention and Treatment of Chemotherapy-Induced Nausea and Vomiting in Patients of Breast Cancer Receiving Highly Emetogenic Chemotherapy
Authors: Vij Soumya , Dhasmana Dilip Chander , Bala Suman , Verma Sanjiv Kumar 
Published: December 2020

Abstract
Background: Chemotherapy is fraught with serious and troublesome adverse effects, of which nausea and vomiting appears earliest and is the most disturbing. Therefore, this study was planned to investigate the antiemetic drug regimens used for chemotherapy-induced nausea vomiting (CINV) in patients with breast cancer receiving highly emetogenic chemotherapy (HEC). Subjects and Methods: An observational follow-up study was conducted to assess the efficacy of antiemetic regimens in breast cancer patients receiving HEC. A total of 71 newly diagnosed patients with breast cancer were included in the study. Patients were assessed for nausea by the visual analog scale, and a history of emetic episodes and need for rescue medication were recorded at 0 h, 6 h, 24 h, 48 h, and 120 h post-chemotherapy till three cycles. Results: The patients were prescribed a combination of ondansetron and dexamethasone (n = 23, n = 17, and n = 13 in first, second, and third cycle, respectively) or a combination of aprepitant, ondansetron, and dexamethasone (n = 48, n = 54 and n = 56 in the first, second, and third cycle, respectively). The intensity of nausea was higher for the patients who were prescribed ondansetron and dexamethasone regimen as compared to patients prescribed aprepitant additionally. Complete response, i.e., no emesis and no rescue medication, was higher in triple-drug regimen (52% vs. 0.4%, 63% vs. 17.6%, and 69% vs. 23% in three cycles, respectively). Conclusion: The control of CINV was better with a combination of aprepitant, ondansetron, and dexamethasone as compared to a regimen without aprepitant.
Total Pelvic Exenteration in Leiomyosarcoma - A Case Report
Authors: Sarkar Atanu , Rai Shweta , Singh Angad , Ghosh Joydeep , Bhaumik Jaydip 
Published: December 2020

AbstractLocally advanced high-grade leiomyosarcomas (LMS) with visceral involvement are difficult to manage. Here, we present a case of locally advanced high-grade sarcoma where total pelvic exenteration was undertaken to achieve complete cytoreduction. A 54-year-old lady with a prior history of hysterectomy and bilateral salpingoophorectomy done 8 years back for heavy menstrual bleeding presented to us with an abdomino-pelvic mass. Magnetic resonance imaging of the abdomen suggested large heterogeneous pelvic mass displacing urinary bladder anteriorly and abutting recto-sigmoid posteriorly with no luminal involvement. There was bilateral hydronephrosis. Computed tomography of the thorax revealed no evidence of metastatic disease. A review of previous biopsy and a repeat ultrasound-guided biopsy from the pelvic mass done at our institute suggested spindle-cell neoplasm. In view of pelvis confined disease in a young woman with well-preserved general condition, decision for surgical excision was taken. She underwent total pelvic exenteration with en bloc removal of mass, bladder, and involved portion of recto-sigmoid as the disease was infiltrating both the bladder and the recto-sigmoid. Her postoperative course was turbulent, but she recovered fully and was discharged 20 days after surgery. The operative specimen histopathology revealed high-grade LMS. She received four cycles of adjuvant chemotherapy and thereafter was kept on follow-up. Although she was clinically doing well, her general condition never improved beyond Eastern cooperative oncology Group 2. She also had persistent depressive symptoms. After 14 months of completion of treatment, she recurred with a huge abdominal disease. In view of her general condition and huge disease volume, decision was taken for supportive care only. LMS in advanced stages are difficult to manage. Even after aggressive management with radical exenterative surgery and chemotherapy, we could achieve only temporary control of locally advanced LMS.
Diagnosing Primary Malignancy in Leptomeningeal Carcinomatosis by Using CSF Cytology and Immunohistochemistry: A Case Report
Authors: Hasthavaram Navaneeth Reddy , Dadu Tina , Duggal Rajan , Qureshi Suhail , Baghmar Saphalta , Agarwal Amit , Khurana Aseem , Sarin Aditya , Singh Navdeep , Kumar Ramesh 
Published: December 2020

AbstractWe present a rare case of recurrent carcinoma of gallbladder with leptomeningeal carcinomatosis. Cerebrospinal fluid (CSF) cytology showed atypical cells, which were suspicious for malignancy on initial reporting. Diagnosis of malignancy and primary from hepatobiliary source was confirmed by doing immunohistochemistry on CSF cell block.
A Case Report and Review of B‑Lineage Acute Lymphoblastic Leukemias with Cannibalistic Lymphoblasts: A Unique Morphologic and Molecular Genetic Entity?
Authors: Bommannan B K , Sachdeva Man Updesh Singh , Naseem Shano , Khadwal Alka , Varma Neelam 
Published: December 2020

AbstractCannibalism is a type of “cell-in-cell” phenomenon commonly described in myeloid lineage malignancies. Although lymphocytes and their precursors are inherently non-phagocytic, there are sporadic case reports describing cannibalism by leukemic lymphoblasts. In the current manuscript, we report the case of a pediatric B-lineage acute lymphoblastic leukemia (B-ALL) patient showing cannibalistic lymphoblasts and have reviewed the clinical and laboratory characteristics of similar cases documented in literature. Our manuscript highlights that all reported B-ALL patients showing cannibalistic lymphoblasts had intra-cytoplasmic vacuolations, and all such treatment-naïve pediatric patients were ETV6-RUNX1 fusion positive and had aberrant expression of myeloid lineage antigens.
Combining Immunotherapy with Multikinase Inhibitors: A Cautious New Promise
Authors: Pramanik Raja , Sharma Atul , Kumar Akash 
Published: December 2020

AbstractImmune check point inhibitors have made a sea change in oncology practice in current times. These drugs have crossed the conventional boundaries of histology and organ of origin. Tumor agnostic approvals for mismatch repair deficient, microsatellite-instability (MSI)-H and recently tumor mutational burden-high solid tumors have been a giant leap. The Oncology community seems poised to embrace the concept of “immunotherapy for all.” Recent studies have evaluated the manipulation of tumor-associated macrophages using multi-kinase inhibitors, to make even MSI low tumor responsive to checkpoint inhibitors. With accelerated food and drug administration approvals, the promise of this combo is palpable but definitely merits caution.
Clinical Profile and Treatment of COVID-19 Patients: Experiences from an Ethiopian Treatment Center
Authors: Abdela Seid Getahun , Abegaz Seid Hassen , Demsiss Wondmagegn , Tamirat Koku Sisay , van Henten Saskia , van Griensven Johan 
Published: December 2020

ABSTRACTCOVID-19 is not well studied in Africa. Understanding the clinical profile and management of COVID-19 will help to plan better prevention and treatment strategies taking the local context into consideration. In this study, we described the clinical profile, treatment used, and outcomes of COVID-19 patients in one of the COVID-19 treatment centers of Ethiopia, Boru Meda Hospital. An institution-based retrospective cross-sectional study was carried out using medical records of COVID-19 patients who were admitted to Boru Meda Hospital with a positive reverse transcription (RT)-PCR result from May 9, 2020 to September 20, 2020. All patients with a positive RT-PCR were admitted to the hospital, regardless of symptom and severity status. A total of 279 COVID-19 patients were included in the final analysis. The median age of patients was 28 years (interquartile range 23–40). The majority (69.5%) were male. Around a quarter (n = 73; 26.2%) of the patients were symptomatic, of which cough (n = 49; 67.1%) and fever (n = 32; 43.8%) were common symptoms. Among symptomatic patients, 48 (65.8%) were mild, four (5.5%) moderate, 12 (16.4%) severe, and nine (12.3%) were critical. The case fatality rate was 2.1%. Hypertension, age older than 25 years, and HIV/AIDS were significantly associated with symptomatic infection. In this study, most of the COVID-19 patients were asymptomatic. However, the proportion of severe and critical patients among those with symptoms was high. More studies are needed to assess the effect of HIV/AIDS on the severity and mortality of COVID-19.
COVID-19 Misinformation and Infodemic in Rural Africa
Authors: Okereke Melody , Ukor Nelson Ashinedu , Ngaruiya Lilian Muthoni , Mwansa Chikwe , Alhaj Samar Mohammed , Ogunkola Isaac Olushola , Jaber Hadi Mohammed , Isa Mashkur Abdulhamid , Ekpenyong Aniekan , Lucero-Prisno Don Eliseo 
Published: December 2020

ABSTRACTThe world has witnessed rapid advancement and changes since the COVID-19 pandemic emerged in Wuhan, China. The significant changes experienced during these times remain unprecedented. The African continent has initiated significant responses to curb the spread of the pandemic. However, there is an increasing concern that rural Africa is facing serious challenges in their responses to the COVID-19 pandemic. This is due to the uncertainty if the populations are detached from or in synch with information on COVID-19. The findings reported here suggest that rural Africa is burdened with misinformation and infodemic regarding COVID-19 due to widespread misconceptions and anecdotal reports. It is, therefore, necessary to engage with community leaders to provide awareness campaigns in rural communities to ensure access to reliable information issued by local and international health authorities. It is pertinent to set up avenues that improve health literacy in communities in rural Africa as it is a major determinant of information assimilation.
De novo construction of a transcriptome for the stink bug crop pest Chinavia impicticornis during late development
Authors: Genevcius Bruno C. , Torres Tatiana T. 
Published: December 2020

Chinavia impicticornis is a neotropical stink bug of economic importance for various crops. Little is known about the development of the species, or the genetic mechanisms that may favor the establishment of populations in cultivated plants. Here, we conduct the first large-scale molecular study of C. impicticornis. Using tissues derived from the genitalia and the rest of the body for two immature stages of both males and females, we generated RNA-seq data, then assembled and functionally annotated a transcriptome. The de novo-assembled transcriptome contained around 400,000 contigs, with an average length of 688 bp. After pruning duplicated sequences and conducting a functional annotation, the final annotated transcriptome comprised 39,478 transcripts, of which 12,665 were assigned to Gene Ontology (GO) terms. These novel datasets will be invaluable for the discovery of molecular processes related to morphogenesis and immature biology. We hope to contribute to the growing body of research on stink bug evolution and development, as well as to the development of biorational pest management solutions.
Urdu Translation and Validation of Trust in Close Relationship Scale
Authors: Batool Syeda Shahida , Jahangier Hira 
Published: December 2020

The current study aimed to translate Trust in Close Relationship Scale in Urdu for married couples in Pakistan and to establish its psychometric properties. The forward and backward translation method was used for the translation of the scale followed by the try-out phase.
After determining the cross language validation, in order to confirm the factor structure of the scale, a confirmatory factor analysis (CFA) was run. The sample comprised of 250 participants of different age groups (M = 39.7, SD = 10.1). The results of CFA supported the original three-factor structure of the scale (viz., Avoidance, Benevolence and Retaliation) by providing a good model fit to the data with values of X2 = 229.61 (df = 110, p < .001), CFI =.91, GFI = .91, and RMSEA = .06. Cronbach’s alpha reliability coefficient of the scale was α= .87. The convergent validity of the scale was determined on a sample of 100 participants by finding its correlation with Trust Scale (r = .72, p < .001). The results support that the scale has promising.
Improvement of Diet Behavior in Clients with Diabetes Mellitus Through Health Education
Authors: Dewi Siti Utami , Furtunah F. D Deinera Rachel 
Published: December 2020

Diabetes mellitus (DM) is a disease that is a problem in public health. DM is a metabolic disorder characterized by hyperglycemia (an increase in serum glucose levels) due to lack of the hormone insulin, decreased effect of insulin and or both. Diet or diet is an important determinant that determines obesity and insulin resistance, so the provision of health education is a way to maintain the stability of insulin in DM clients. This case study aims to get an overview of the implementation of health education in improving the eating habits of DM clients. The method used is descriptive in the form of case studies with the criteria that the subject is a family with diabetes mellitus health problems through health education intervention about diet. The results of the case study showed that there was a decrease in blood sugar levels, good motivation of the families in implementing the DM diet, and behavioral changes by 76% (good category) in subject I, as far as subject II behavior change was 80% (good category ) Based on the results of this case study it is expected that nurses through health cadres are able to monitor the implementation of DM diet in families with optimal DM health problems.

Keywords:	Diabetes Mellitus, Blood Sugar Levels, Implementation of A Diet of Diabetes Mellitus
Knowledge of Technology Poultry Production and Entrepreneurship For Development of Indigenous Chicken Farms in Indonesia
Authors: Mappigau Palmarudi , Amar Muhammad Yunus 
Published: December 2020

The objective of this study is to analyze the knowledge of technology poultry production and entrepreneurship for the development of indigenous chicken farms. The research location Sidrap and Bone regencies, South Sulawesi Province, Indonesia. The data collected through direct observation and structured interviews with 96 indigenous chicken farmers. The data analyzed by descriptive statistics and Spearman's Rank correlation. The results showed that the development of indigenous chicken farms was decreasing and not increasing in the number of chickens, the knowledge of farmer respondents in technology poultry production and entrepreneurship was categorized as inadequate. The results show that in the technology poultry production, knowledge of suitable feed, and control and prevention of disease have a positive and significant relationship with the development of indigenous chicken farms. In entrepreneurial knowledge, knowledge of results-oriented and opportunity-seeking have a positive and significant relationship with the development of indigenous chicken farms. The conclusion, the technology poultry production, and entrepreneurship knowledge have an important role in the development of indigenous chicken farms