bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Does Our Voice Change as We Age? A Systematic Review and Meta-Analysis of Acoustic and Perceptual Voice Data From Healthy Adults Over 50 Years of Age
Authors: Rojas Sandra , Kefalianos Elaina , Vogel Adam 
Published: February 2020

Purpose
Approximately 30% of adults over the age of 50 years present with altered vocal function. Our understanding of how these changes manifest acoustically and perceptually is derived from relatively modest-sized studies using a diversity of tools. Voice changes can arise from the onset of disease or disorder, but also age-related physiological changes, which may not reflect pathology as such. Here, we bring together data on acoustic, perceptual, and instrumental assessments (electroglottography), with the aim of gaining a better understanding of the changes occurring across these measurement domains. We consider these changes in the context of different acoustic features, software programs, and perceptual protocols.

Method
Studies of voice function in healthy older adults over the age of 50 years were sought. Literature was systematically searched with 746 abstracts reviewed. Forty-seven studies were included in the review. A meta-analysis of included studies compared voice acoustic parameters between sex and age. Sixteen acoustic parameters collected from 1,475 participants were analyzed in the meta-analysis. These included some previously unpublished analyses using data provided by authors of included studies.

Results
Data from the systematic review suggest that older individuals are perceived to present with higher overall scores of dysphonia and roughness, breathiness, strain, and instability. Acoustically, males have significantly higher scores on measures of perturbation, including noise-to-harmonic ratio and absolute jitter. The meta-analysis outcomes suggest that participants aged 80–89 years produce significantly higher fundamental frequency, jitter percent, shimmer percent, and shimmer in decibels compared to participants aged 60–69 years and a significant increase in relative average perturbation, jitter percent, and shimmer in decibels compared to participants aged 70–79 years. Limited data were available comparing acoustic measures using the same acoustic software.

Conclusions
Variations in fundamental frequency and frequency and amplitude perturbation increase as healthy adults age. It was difficult to draw definitive conclusions based on existing literature due to variability in hardware used, limited descriptions of study cohorts, or missing data from statistical analysis.

Supplemental Material

https://doi.org/10.23641/asha.11868663
Is there Na I in the atmosphere of HD 209458b?
Authors: Casasayas-Barris N. , Pallé E. , Yan F. , Chen G. , Luque R. , Stangret M. , Nagel E. , Zechmeister M. , Oshagh M. , Sanz-Forcada J. , Nortmann L. , Alonso-Floriano F. J. , Amado P. J. , Caballero J. A. , Czesla S. , Khalafinejad S. , López-Puertas M. , López-Santiago J. , Molaverdikhani K. , Montes D. , Quirrenbach A. , Reiners A. , Ribas I. , Sánchez-López A. , Zapatero Osorio M. R. 
Published: February 2020

HD 209458b was the first transiting planet discovered, and the first for which an atmosphere, in particular Na I, was detected. With time, it has become one of the most frequently studied planets, with a large diversity of atmospheric studies using low- and high-resolution spectroscopy. Here, we present transit spectroscopy observations of HD 209458b using the HARPS-N and CARMENES spectrographs. We fit the Rossiter-McLaughlin effect by combining radial velocity data from both instruments (nine transits in total), measuring a projected spin-orbit angle of − 1.6 ± 0.3 deg. We also present the analysis of high-resolution transmission spectroscopy around the Na I region at 590 nm, using a total of five transit observations. In contrast to previous studies where atmospheric Na I absorption is detected, we find that for all of the nights, whether individually or combined, the transmission spectra can be explained by the combination of the centre-to-limb variation and the Rossiter-McLaughlin effect. This is also observed in the time-evolution maps and transmission light curves, but at lower signal-to-noise ratio. Other strong lines such as Hα, Ca II IRT, the Mg I triplet region, and K I D1 are analysed, and are also consistent with the modelled effects, without considering any contribution from the exoplanet atmosphere. Thus, the transmission spectrum reveals no detectable Na I absorption in HD 209458b. We discuss how previous pioneering studies of this benchmark object may have overlooked these effects. While for some star–planet systems these effects are small, for other planetary atmospheres the results reported in the literature may require revision.
Stellungnahme der Gesellschaft für Kinder- und Jugendrheumatologie bezüglich der Verwendung von Biosimilars
Authors: Urban Andreas C. , Keller Thomas , Haas Johannes-Peter 
Published: February 2020

ZUSAMMENFASSUNGDie rheumatologische Erkrankungssituation von Kindern und Jugendlichen ließ sich früher über die konventionellen Therapieverfahren zwar sehr positiv verbessern, jedoch erweiterte die Zulassung der Biologika für den pädiatrischen Rheumabereich die Möglichkeit zur Krankheitskontrolle und Verbesserung der Lebensqualität erheblich. Mit Ablauf des Patentschutzes der ursprünglich zugelassenen Biologika (Originatoren) ist es nun möglich, fast identische Medikamente mit gleichem Wirkprinzip zuzulassen (Biosimilars). Da Biosimilars ein deutliches monetäres Einsparpotenzial mit sich bringen, wird diskutiert, vorrangig Biosimilars an Stelle von Originatoren einzusetzen. Die aktuelle Stellungnahme der Deutschen Gesellschaft für Kinder- und Jugendrheumatologie soll eine Hilfestellung für die kindlichen und jugendlichen Patienten/innen wie auch für die Ärzte/innen im Umgang mit den Biosimilars sein. Die bisherigen Erfahrungen zeigen, dass mit der Einführung von Biosimilars kein Wirkverlust gegenüber den Originatoren verbunden ist.
Peer-to-Peer-Selbsthilfe-Interventionen für Geflüchtete – eine Pilotstudie
Authors: Jumaa Jinan Abi , Kluge Ulrike , Weigold Stefanie , Heinz Eustachia , Mehran Nassim 
Published: February 2020

ZusammenfassungDie Ankunft einer großen Anzahl Geflüchteter in Deutschland seit 2015 hat zu wachsenden Herausforderungen im Gesundheitssystem geführt, auch im psychosozialen Bereich. Um die Kenntnisse Geflüchteter über die Angebote im psychosozialen Bereich zu verbessern und erste Hilfestellungen anzubieten, wurden an der Klinik für Psychiatrie und Psychotherapie der Charité-Universitätsmedizin Berlin eine manualisierte Peer-to-Peer-Unterstützung (P2P) entwickelt und P2P-Trainer/innen ausgebildet. In der hier beschriebenen Pilotstudie wurden vier P2P-Gruppen mit männlichen und weiblichen farsi / dari- oder arabischsprachigen Geflüchteten ausgewertet. Die Teilnehmenden wurden in Einzelinterviews zu wahrgenommenen Vor- und Nachteilen der P2P-Gruppe sowie ihrer Präferenzen und Erwartungen befragt. Die Daten wurden mithilfe der Software MAXQDA kodiert und thematisch analysiert. Alle Teilnehmenden der Gruppen äußerten Zufriedenheit mit dem P2P-Gruppenangebot. P2P half ihnen dabei, soziale Kontakte aufzubauen und soziale Unterstützung zu finden. Eine Flexibilisierung der P2P-Interventionen, ausgerichtet an individuellen Bedürfnissen, wurde gewünscht. Die Ergebnisse unserer Studie legen nahe, dass P2P-Ansätze die Integration von Geflüchteten in die psychosoziale Versorgung verbessern können.
Comparison of semiquantitative metabolic parameters of the primary tumor obtained in PET/CT with 18F-FDG and 18F-FLT in patients with cervical cancer
Authors: Cegła Paulina , Burchardt Ewa , Cholewiński Witold , Gwóźdź Sebastian , Roszak Andrzej , Kubiak Anna , Kaczmarek Aleksandra , Czepczyński Rafał 
Published: February 2020

Abstract
Aim The aim of the study was to compare semiquantitative metabolic parameters of primary tumor assessed in vivo in 18F-FDG- and 18F-FLT in cervical cancer patients.
Material & Methods 39 patients with histologically confirmed cervical cancer underwent PET/CT scans acquired on separate days 60 min after i. v. injection of 364 ± 75 MBq of 18F-FDG and 259 ± 40 MBq of 18F-FLT. The reconstructed PET images were evaluated using a dedicated workstation for primary tumor semiquantitative parameters: SUVmax, MTV, TLG (for 18F-FLT-TLP) and heterogeneity (AUC-CSH). Wilcoxon-Mann-Whitney test and ROC curves were used for statistical analysis. Based on data from the local cancer registry and 3y- to -5y follow up patients were divided into 2 groups with regard to prognosis. Also differences between histopathological type and FIGO classification in two tracers were assessed.
Results Depending on PET/CT results, patients were divided into 3 groups: group 1 with disease limited only to the cervix, group 2 with disease limited to the cervix and iliac lymph nodes, and group 3 with disseminated disease. Statistically significant differences were found between keratinizing and non-keratinizing SCC in SUVmax (p = 0.03) and AUC-CSH (p = 0.04) only in 18F-FLT-PET/CT. Following cut-off values for nodal involvement in SUVmax, MTV, TLG/TLP and AUC-CSH were calculated using ROC curves: 13.5, 39.22, 255.94, 0.59 respectively for 18F-FDG and 12.1, 37.59, 140.01, 0.46 respectively for 18F-FLT. Higher values in both tracers in MTV and TLG/TLP were found in a group with worse prognosis.
Conclusion This preliminary study suggests that higher values in MTV and TLG/TLP in both tracers might be associated with worse outcome in cervical cancer patients.
Single Atrium and Miscarriages
Authors: Kojqiqi Fatos , Kojqiqi Arben , Jusufi Ismet , Kojcici Besnik 
Published: February 2020

Abstract
Background A single atrium is a very rare heart condition, in which the inter atrial septum is missing. These congenital heart defects usually are surgically corrected after birth.
Case Presentation We present a successful surgical repair of a single atrium (SA) in a 27-year-old woman, who has a complete missing of the atrial septum, without coexisting valvular pathology. The SA diameter was 9.97 × 6.18 cm and the Systemic blood flow/pulmonary blood flow (Qp/Qs) was 4.1 due to the single atrium. Surgical correction consisted of creating a new atrial septum, using a double-velor patch. At first- and second-year follow up, the patient was in a very good condition and without any symptoms present. We consider that the diagnoses of single atrium, especially in child bearing women, should be done in appropriate time, to avoid miscarriages, preterm births and other complications associated.
Conclusion There are many case reports that show good surgical repair of single atrium and without late complications. In our case, we have obtained a very good surgical repair, without AV bundle damage and no residual shunt demonstrated on intraoperative transesophageal echocardiography.
Clostridioides difficile Spores: Bile Acid Sensors and Trojan Horses of Transmission
Authors: Shen Aimee 
Published: February 2020

AbstractThe Gram-positive, spore-forming bacterium, Clostridioides difficile is the leading cause of healthcare-associated infections in the United States, although it also causes a significant number of community-acquired infections. C. difficile infections, which range in severity from mild diarrhea to toxic megacolon, cost more to treat than matched infections, with an annual treatment cost of approximately $6 billion for almost half-a-million infections. These high–treatment costs are due to the high rates of C. difficile disease recurrence (>20%) and necessity for special disinfection measures. These complications arise in part because C. difficile makes metabolically dormant spores, which are the major infectious particle of this obligate anaerobe. These seemingly inanimate life forms are inert to antibiotics, resistant to commonly used disinfectants, readily disseminated, and capable of surviving in the environment for a long period of time. However, upon sensing specific bile salts in the vertebrate gut, C. difficile spores transform back into the vegetative cells that are responsible for causing disease. This review discusses how spores are ideal vectors for disease transmission and how antibiotics modulate this process. We also describe the resistance properties of spores and how they create challenges eradicating spores, as well as promote their spread. Lastly, environmental reservoirs of C. difficile spores and strategies for destroying them particularly in health care environments will be discussed.
Participation in and Gains from Traditional Vegetable Value Chains: a Gendered Analysis of Perceptions of Labour, Income and Expenditure in Producers’ and Traders’ Households
Authors: Fischer Gundula , Patt Nicolas , Ochieng Justus , Mvungi Henry 
Published: February 2020

AbstractHorticulture is one of the fastest growing subsectors of agriculture in Tanzania. Gender relations in vegetable-producing and vegetable-trading households need to be understood to make value chain development equitable. This study, carried out in northern and central Tanzania, is based on data from surveys, focus group discussions and semi-structured interviews. The perceptions of men and women traders and producers are investigated with regard to labour participation in traditional vegetable value chains and gains (income and expenditure) from it. Farmers were found to report more balanced intra-household labour arrangements paired with less-balanced income and expenditure shares, while traders indicated less-balanced labour contributions that went hand in hand with more-balanced shares of benefits. Farmers related limited household development not only to imbalances in benefits but also to a lack of trust and cooperation between spouses. The importance of gender-transformative approaches in agricultural value chains is emphasized herein.
Turns of the centuries. The Transkribus automated tool for recognition, transcription and translation of handwritten
historical documents
Authors: Vukčević Miodrag M. 
Published: February 2020

Abstract
The translation of handwritten historical documents faces many challenges due to variation in the writing style,
local language, and an inevitable language change. Even the transliteration from Cyrillic to Latin characters is standardized by
the bijective transliteration standard ISO 9. This presentation introduces a number of tools offered by Transkribus for the
automated processing of documents, such as Handwritten Text Recognition (HTR) and Document Understanding, which are needed for the
translation of historical documents. Next to the problem of decoding handwritten documents, written for example in Kurrentschrift
using ancient terminology, changed meanings and different spelling have additionally to be considered during the translation of
texts from earlier centuries. Resolution strategies on a case study show different methods for ensuring quality translations.
‘Cinema as a common activity’
Authors: Ozduzen Ozge 
Published: February 2020

Abstract
This paper is concerned with the ways in which mediating spaces like film festivals function as alternative public
spheres when social movements escalate, arguing that the Istanbul International Film Festival and Documentarist right before,
during and following the Gezi protests turned into politically and socially inclusive spaces for marginalised groups in Turkey. To
account for how audiences and organisers aimed to transform these mediating spaces into socially inclusive and heterogeneous
outlets during the Gezi protests, the paper relies on an audience ethnography in the sites of these film festivals from 2013 until
2017 including participant observation, go-alongs and in-depth interviews with audiences, film crews and organizers. Although the
spaces of these two film festivals functioned differently, the article shows that film festival spaces generally transformed into
cosmopolitan outlets in Istanbul in this period, opening room for a dialogue between marginalised and dominant groups, which was
fed by social movements
Influence of organised sports practice during adolescence on health of adult women with special emphasis on participation in aesthetic sports
Authors: Mayolas‐Pi C. , Sitko S. , Oviedo‐Caro M. A. , Bueno‐Antequera J. , Reverter‐Masià J. , Francín‐Gallego M. , Sarasa‐Oliván F. J. , Legaz‐Arrese A. 
Published: February 2020

AbstractThis study aimed to assess the differences in psychosocial health and cardiometabolic risk during adulthood in women based on previously organised sport (OS) participation during adolescence and current activity levels, with emphasis on participation in aesthetic sports. The study included 1947 women aged 18–55 years who were categorised into four groups: 355 aesthetic athletes during adolescence, 494 non‐ aesthetic athletes during adolescence, 791 non‐athletes during adolescence with similar current levels of physical activity (PA) to OS groups and 307 currently inactive non‐athletes during adolescence. Participants answered questionnaires regarding sport participation, psychosocial health and cardiometabolic risk. The results show that non‐athletes during adolescence who are currently inactive reported significantly lower psychosocial health and higher cardiometabolic risk scores. Women with currently homogenous PA levels (χ² = 0.514) reported similar physical quality of life (QoL), exercise addiction, anxiety and depression symptoms regardless of participation in OS during adolescence (P > .05), except aesthetic athletes who reported the worst sleep and mental QoL. Very high training volumes in aesthetic athletes did not influence psychological outcomes and cardiometabolic risk in adulthood compared to lower training volumes. In conclusion, the effects of PA during adulthood appear to be powerful enough to induce beneficial adaptations in health outcomes that match those observed in women who participate in OS during adolescence, except for aesthetic sports participants, who show a high risk of lower quality of sleep in adulthood. PA should be promoted in adults and especially women who have not participated in OS during adolescence.
Heart rate recovery responses after acute training load changes in top‐class water polo players
Authors: Botonis Petros G. , Arsoniadis Gavriil G. , Platanou Theodoros I. , Toubekis Argyris G. 
Published: February 2020

AbstractThe purpose of the study was to investigate the effects of acute training load changes of elite water polo players on heart rate recovery (HRR) responses after a standardized swimming test. Nine water polo players were tested after a two‐day light‐load and two‐day heavy‐load training. Preliminarily, critical swimming speed was calculated. Testing comprised of an intermittent 4 × 100‐m swimming separated by 10 s of rest with an intensity corresponding to 85% of their maximum speed previously attained during a 100‐m swim test followed immediately by assessment of HRR. Internal training load (ITL) was measured using the rating of perceived exertion and the duration of training sessions. The swimming speed corresponded to 1.43 ± 0.06 m·s−1 and 1.45 ± 0.06 m·s−1 after light‐load and heavy‐load training, respectively (p = 0.06, d = 0.74). ITL was increased in high‐load compared to light‐load training (p < 0.001, d = 11.54). The difference in HR at end of exercise (HR‐end) and after 60 s rest and the difference in mean HR during last min of exercise and HR after 60 s rest were higher in light‐load training (p < 0.05, d = 0.85–1.15). The absolute change in ITL was correlated with the respective change in the percentage change of HR‐end at 10 s of recovery (%HRR10s) (r = 0.72, p = 0.03). Significant correlation was observed between the percentage change of ITL with the %HRR10s (r = 0.67, p = 0.05). We conclude that HRR tracks acute changes in training load. The lower HRR following high‐load training likely indicates a blunted parasympathetic re‐activation.
Amplification performance outcome
Authors: Trimmis Nikolaos , Ziavra Nausica , Papadas Theodoros , Naxakis Stefanos 
Published: February 2020

Purpose:
The aim of this study was the development of a simple instrument, in order to be established as a self-assessment tool, about the benefits from amplification systems in Greece. This instrument is called the Amplification Performance Outcome or APO.

Method:
The current scale is comprised of 6 subscales addressing different domains with a total of 30 items. A five-point Likert scale was used to capture data. The complete APO typically requires 18 min or less to complete with each subscale requiring less than 3 min. It was evaluated on 100 hearing aid users, ages between 23 and 88 years old, with mild to severe sensorineural hearing loss bilaterally. Data from 62 subjects were used to examine the test–retest properties of the instrument. All the participants were users of amplification with unilateral or bilateral fitting for about 4–12 weeks.

Results:
The overall mean scores (%) for positive, neutral and negative responses indicated a considerable overall benefit from hearing amplification. The positive responses occupy 73.6%, the negative responses occupy 15.9% and neutral responses occupy 10.5% of total responses. The psychometric properties of APO appear to be acceptable. The scale appears to have high face, content and convergent validity. Results also revealed high test–retest reliability and internal consistency.

Conclusion:
These results reveal that the APO scale is a potentially valuable clinical instrument, and may help to provide more standardization to the hearing aid evaluation process. Future research will be needed to obtain multiple outcome measures from large numbers of individuals to determine whether this self-assessment scale would suffice.
Safety analysis of the irradiation of Tellurium (Te) target in G.A. Siwabessy Reactor
Authors: Sutrisno  , Rohman Hakim Abdul Aziz , Purwadi  
Published: February 2020

Abstract
Safety Analysis of the Irradiation of Tellurium (Te) Target in G.A. Siwabessy Reactor. Providing public service becomes one of the priority programs made by the Head of BATAN, such a program is the radioisotope production of Iodine 131 (I-131), which emits gamma and beta that are utilized for medical purpose. The radioisotope can be produced by irradiating the target of Tellurium dioxide (TeO2) on the G.A. Siwabessy Reactor core. Tellurium dioxide (TeO2) is irradiated on the position of Central Irradiation Position (CIP) D-6 and E-7 because the Irradiation Position (IP) is used for Topaz irradiation and CIP (D-6, E-7) is used for the irradiation of Low Enriched Uranium (LEU). Based on the several safety requirements such as analyze the optimum amount of the Tellurium target on CIP (D-6, E-7) with Topaz and LEU. The scope of the research includes the reactivity disturbance, radial power peaking factor and thermohydraulic disturbance. The diffusion group constant of the model uses the program of WIMSD-5B and the result is used for calculating reactivity disturbance and radial power peaking factor with the program package of BATAN-2DIFF. The thermohydraulic disturbance is calculated with using the Generalized Gap Temperature Calculation (GENGTC) program. The calculation of the reactivity of 750 gram (6x125 gram) Tellurium is resulting the change of negative reactivity of-0.27% Δk/k and the value of radial power peaking factor is 1.34 and the temperature at the center of TeO2 target is 366.7°C and outside the capsule (Aluminum) is 58.39°C, if it is compared to the safety margin of ± 2% Δk/k, PPFrad max=2.6, melting point of Al=660°C, melting point of Te=449.5°C, so all the parameters still meets the safety requirement.