bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examination of physicians’ adherence to the 2013 ACC/AHA statin/cholesterol guidelines using a framework of awareness to adherence: A cross-sectional study
Authors: Fleming Marc L , Rege Sanika , Johnson Michael L , Serna Omar , Esse Tara , Choi Jeannie , Abughosh Susan M 
Published: August 2020

Background Currently, limited data exists regarding primary care physicians’ awareness and implementation of the 2013 cholesterol guidelines. Objectives To evaluate primary care physicians’ adherence to the 2013 ACC/AHA cholesterol management guidelines using the framework of the awareness-to-adherence model. Methods The study was a cross-sectional pre-post survey design based on the constructs of the awareness-to-adherence model to capture physicians’ awareness of, agreement with, adoption of, and adherence to the 2013 ACC/AHA guidelines for cholesterol treatment and statin and cholesterol management software applications. Physicians with a Medicare Advantage organization in Texas were surveyed before and after educational interventions. Results A total of 170 responses were considered usable (post-survey). A significant difference was observed when physicians were divided into 2 groups (any intervention vs no intervention) ( P = .027). Physicians with a higher level of agreement were 4.8 times more likely to be adherent to the guidelines ( P = .011), compared with those with a lower level of agreement. Also, physicians practicing in the Rio Grande Valley area were 4.7 times more likely to be adherent to the guidelines ( P = .001) compared with those from the Greater Houston area. Conclusion A high level of awareness, but a lower level of adherence to the guidelines was reported among responding physicians. The awareness-to-adherence model was useful in examining physicians’ level of adherence to the cholesterol guidelines and the utilization of statin and cholesterol management cellular apps and online websites. Future studies are required to examine physicians’ adoption and adherence of new guidelines.
What Can China Learn From Evidence-Based Educational Reform? A Comparative Review of Educational Technology Programs’ Effects on Mathematics Achievement
Authors: Xie (谢晨) Chen 
Published: August 2020

Purpose: This review contrasts the U.S. and Chinese mainland in terms of educational technology programs’ effects on mathematics achievement. The existing evaluation studies are assessed and compared, especially from the perspective of research quality. Moreover, this review finds out what intervention programs work in these two countries and classifies evidence levels of effective programs. Design/Approach/Methods: A systematic review and meta-analysis method is used. Findings: The application of educational technology programs produced a better effect in Chinese mainland than in the U.S., however, the quantity and quality of evaluation studies is concerning in Chinese mainland. Since 2010, four programs in the U.S. and one program in Chinese mainland have qualified for strong evidence of effectiveness, which are worthy of receiving scale-up grants. Originality/Value: This is the first systematic review to contrast the U.S. and China in terms of educational technology programs’ effects on mathematics achievement. Determining what works through high-quality experiments is probably the most important requirement for evidence-based reform in education. This review compares the developments of the U.S., a leader of the movement, with those of China, an undecided observer. The review may provide enlightenment for the undecided countries and regions.
Emerging research trends and foci of studies on the meniscus: A bibliometric analysis
Authors: Zhou Tianping , Xu Yihong , Xu Weidong 
Published: August 2020

Introduction: Meniscus has always been the focus of sport medicine with thousands of articles published annually. Few study has tried to analyze these papers with bibliometric methods. The purpose of this study is to statistically analyze the output of meniscus research and determine emerging research trends and hot spots. Methods: Papers related to the meniscus published from 2010 to 2019 were downloaded from the Web of Science Core Collection. Information about annual publications and journal distribution was analyzed by Excel 2016. Co-occurrence analysis of the countries/regions, institutions, authors, and keywords were performed with CiteSpace V, which was also used to perform a co-cited analysis of the references and generate corresponding knowledge maps as well as detect burst keywords. Results: A total of 10,066 articles regarding meniscus were published between 2010 and 2019. The number of articles annual about meniscus increased from 786 to 1300. Knee Surgery Sports Traumatology Arthroscopy, the United States, University of Pittsburgh, and LaPrade RF were journal, country, institution, and author with the most publications, respectively. Makris EA et al. in 2011 was the most cited articles, with a citation of 198. Osteoarthritis, tear repair, anterior cruciate ligament, and articular cartilage were keywords with occurrence of more than 500. Meniscal extrusion, scaffold, and tissue engineering were terms with most burst strength. Conclusions: Meniscus-related publications showed a gradual rising trend from 2010 to 2019. Osteoarthritis, tear repairs, and the anterior cruciate ligament are the current research hot spots. Extrusion and scaffolds may be the frontiers of meniscus research in the next few years. Level of evidence: IV.
Relationship Between Age at Adult Height and Knee Mechanics During a Drop Vertical Jump in Men
Authors: Steffensmeier Andrew M. , Lamont Sarah M. , Metoyer Garyn , DiPaolo Zachary , Froehle Andrew W. 
Published: August 2020

Background: Anterior cruciate ligament (ACL) injuries are relatively common among younger athletes, with significant physical, psychological, and financial consequences. Research has largely focused on female athletes by identifying specific risk factors for an ACL injury, including variation in pubertal growth timing. There is less known about risk factors in males, and little is known about the effects of pubertal development on ACL injury risk in men. Purpose/Hypothesis: The purpose of this study was to analyze the relationship between an indicator of pubertal growth timing (age at adult height) and biomechanical risk for ACL injuries in men. We hypothesized that earlier age at adult height is correlated with riskier landing biomechanics during a drop vertical jump (DVJ) in men. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A total of 21 recreationally active male students (age range, 20-33 years) were included. Participants completed a questionnaire on age at adult height and limb dominance, and anthropometric measurements were taken. There were 6 DVJ tests performed, with participants landing on a force plate while digital cameras recorded kinematic data from retroreflective markers placed according to the Helen Hayes marker system. Primary outcomes were sagittal and frontal plane knee kinematics and kinetics during contact. Data were analyzed using Pearson product-moment correlation. Results: In both limbs, age at achieving adult height was significantly negatively correlated with knee flexion/extension angle at toe-off (dominant: r = –0.79, P < .01; nondominant: r = –0.74, P < .01) and with peak flexion (dominant: r = –0.63, P < .01; nondominant: r = –0.70, P < .01) and extension (dominant: r = –0.66, P < .01; nondominant: r = –0.56, P = .01) angles during contact. In the nondominant limb, age at adult height was significantly negatively correlated with varus/valgus angle at initial contact ( r = –0.43; P = .05) and toe-off ( r = –0.44; P = .04) and was positively correlated with peak varus moment during contact ( r = 0.42; P = .06). Age at adult height was also positively correlated with peak vertical ground-reaction force ( r = 0.58; P < .01). Conclusion: Later age at adult height was correlated with riskier landing profiles in this study. This suggests that males with later or longer pubertal growth may have increased mechanical risk for ACL injuries. A better understanding of the effects of pubertal growth on landing biomechanics can improve the early identification of male athletes at greater risk for injuries.
Considerations for Pregnant Dental and Health Care Workers amid COVID-19
Authors: Mann A. , Dahiya A. , Souza L.C. , Letra A. 
Published: August 2020

Introduction: Coronavirus disease 2019 (COVID-19) is a highly contagious disease that quickly reached pandemic levels. Over 5 million COVID-19 cases and approximately 330,000 deaths have been recorded worldwide. Transmission is primarily spread through direct, indirect (through contaminated objects or surfaces), or close contact with infected people via respiratory droplets, the mouth, and/or nose secretions. Health care professionals (HCPs), including dental HCPs, are recognized to be at considerably high risk for infection due to the close proximity to patients and aerosol-generating procedures. During pregnancy, HCPs may be at even higher risk since pregnancy substantially increases the susceptibility to infectious diseases. Objectives: Here, we present the posed risks and potential effects of COVID-19 on maternal and fetal health. Current prevention and management strategies for COVID-19 on pregnant dental and HCPs are also discussed. Results: Significant progress is being made in understanding the pathogenesis and clinical consequences of COVID-19. Pregnant women are affected more adversely with viral illnesses, although evidence of vertical transmission of COVID-19 is controversial. Based on the presence of atypical symptoms, the significant numbers of asymptomatic individuals who are COVID-19 positive, and the high susceptibility to viral diseases observed in pregnant women, recommendations have been put forth to limit the exposure of COVID-19–positive or even suspected cases to pregnant HCPs, and these are likely to evolve as new information becomes available. Conclusion: Pregnant HCPs require extra caution: not only are they considered a high-risk population, but their work at the frontline in a pandemic may expose them to additional risks. Complete awareness of the effects of COVID-19 on maternal and fetal/infant health, as well as prevention and management guidelines for pregnant HCPs, will allow for a safer work environment. Health care institutional policies aimed at protecting pregnant HCPs should consider avoiding their assignment as first responders, especially if equally trained staff are available. Knowledge Transfer Statement: Dental and health care professionals can use the information in this review to improve their awareness of COVID-19 risks, signs, and symptoms and the associated effects on the health of pregnant health care professionals and their unborn/newborn children.
Nosology of the Sexual Dysfunctions: Are They Appropriate to Older Adults?
Authors: D’cruz Migita , Andrade Chittaranjan 
Published: August 2020

The International Classification of Diseases, Tenth Revision ( ICD-10), describes sexual dysfunction on the basis of the inability of the individual to participate in a sexual relationship. On the other hand, the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) ( DSM-5) describes it as the inability to respond sexually or experience sexual pleasure. Neither diagnostic manual addresses age as a contextual factor in sexual response, though DSM-5 notes that aging may be associated with a normative decrease in sexual response. In this review, we argue that the diagnosis of sexual dysfunction in the elderly should be based on age-related expectations. As examples, in older women, diagnostic criteria should factor in the considerations that vaginal dryness is associated with genital pain on penetration and with anorgasmia, as components of the genitourinary syndrome of menopause. In older men, the criteria for rigidity of erection and time to ejaculation may be unduly stringent and are not calibrated to changes in autonomic function with age. The lack of consideration of aging physiology in diagnostic systems and the predominance of ageist stereotypes restrict the validity of diagnoses of sexual dysfunction in older adults; there is the possibility of both under and over diagnosis, based upon the attribution models of the patient and the clinician. Age sensitivity during medical training would help reduce ageist stereotyping in clinical practice. Sexual health education in older adults would help familiarize them with and relieve distress related to body changes that may be distressing and that may impact their quality of sexual life.
A phase 3 randomized study (HOMER) of ofatumumab vs rituximab in iNHL relapsed after rituximab-containing therapy
Authors: Maloney David G. , Ogura Michinori , Fukuhara Noriko , Davis Jaclyn , Lasher Janet , Izquierdo Miguel , Banerjee Hiya , Tobinai Kensei 
Published: August 2020

Abstract
Because of high relapse rates with rituximab combinations, there is an unmet need for new therapeutic agents for treatment of indolent B-cell non-Hodgkin lymphoma (iNHL) or follicular lymphoma (FL). In previous trials, ofatumumab in combination with chemotherapy showed good results in relapsed/refractory FL pretreated with rituximab. This phase 3 trial evaluated the efficacy and safety of single-agent ofatumumab vs single-agent rituximab in rituximab-sensitive relapsed FL that relapsed at least 6 months after completing the last prior treatment with single-agent rituximab or a rituximab-containing regimen. Patients were randomized 1:1 to receive either ofatumumab (1000 mg) or rituximab (375 mg/m2) every week for 4 weeks for the induction phase, followed by once every 2 months for 4 additional doses. The primary endpoint, progression-free survival (PFS) and secondary endpoints, overall response rate (ORR) and overall survival (OS), were evaluated. Overall, 438 patients were assigned to receive ofatumumab (n = 219) and rituximab (n = 219). Baseline characteristics were similar in both arms. The independent review committee assessed whether median PFS was shorter in the ofatumumab arm than in the rituximab arm (16.33 vs 21.29 months), with no significant difference (hazard ratio, 1.15; 95% confidence interval, 0.89-1.49; P = .29) and also showed a lower ORR (50%) compared with the rituximab arm (66%). At the time of analysis, data were not matured for OS results. The number of grade &gt;3 adverse events was higher in the ofatumumab arm (37%) than the rituximab arm (28%). Ofatumumab showed no superiority over rituximab in patients with FL who had relapsed after a rituximab-containing therapy. This study was registered at www.clinicaltrials.gov as #NCT01200589.
Investigating cystic lung disease: a respiratory detective approach
Authors: Ennis Samantha , Silverstone Elizabeth J. , Yates Deborah H. 
Published: August 2020

The cystic lung diseases are rare orphan lung disorders that most physicians will see infrequently in their everyday practice. Diagnostic and treatment options have improved over recent decades, with opportunities for slowing rate of progression and improving outcome for patients. This review provides a summary of the clinical approach to these lung disorders, including how to differentiate between different imaging patterns, clinical features, differential diagnosis and characteristics of the commonest presenting disorders.Educational aimsTo understand the clinical, pathological and radiological features of cystic lung disordersTo explore the differential diagnosis of cystic lung diseaseTo be familiar with the key features (clinical, radiological, physiological and pathological) of the commoner cystic lung diseases, which assist in differentiating between these
Formability of Materials with Small Tools in Incremental Forming
Authors: Wei Hongyu , Hussain G. , Shi X. , Isidore B. B. L , Alkahtani Mohammed , Abidi Mustufa Haider 
Published: August 2020

AbstractSingle point incremental forming (SPIF) is an innovative sheet forming process with a high economic pay-off. The formability in this process can be maximized by executing forming with a tool of specific small radius, regarded as threshold critical radius. Its value has been reported as 2.2 mm for 1 mm thick sheet materials. However, with a change in the forming conditions specifically in the sheet thickness and step size, the critical radius is likely to alter due to a change in the bending condition. The main aim of the present study is to undertake this point into account and develop a relatively generic condition. The study is composed of experimental and numerical investigations. The maximum wall angle (θmax) without sheet fracturing is regarded as sheet formability. A number of sheet materials are formed to fracture and the trends correlating formability with normalized radius (i.e., R/To where R is the tool-radius and To is the sheet thickness) are drawn. These trends confirm that there is a critical tool-radius (Rc) that maximizes the formability in SPIF. Furthermore, it is found that the critical radius is not fixed rather it shows dependence on the sheet thickness such that Rc = βTo, where β varies from 2.2 to 3.3 as the thickness increases from 1 mm to 3 mm. The critical radius, however, remains insensitive to variation in step size ranging from 0.3 mm to 0.7 mm. This is also observed that the selection of tool with R < Rc narrows down the formability window not only on the higher side but also on the lower side. The higher limit, as revealed by the experimental and FEA results, diminishes due to excessive shearing because of in-plane biaxial compression, and the lower limit reduces due to pillowing in the bottom of part. The new tool-radius condition proposed herein study would be helpful in maximizing the formability of materials in SPIF without performing experimental trials.
First insight into the whole-genome sequence variations in Mycobacterium bovis BCG-1 (Russia) vaccine seed lots and their progeny clinical isolates from children with BCG-induced adverse events
Authors: Narvskaya Olga , Starkova Daria , Levi Diana , Alexandrova Natalia , Molchanov Vladimir , Chernyaeva Ekaterina , Vyazovaya Anna , Mushkin Alexander , Zhuravlev Viacheslav , Solovieva Natalia , Vishnevskiy Boris , Mokrousov Igor 
Published: August 2020

Abstract
Background
The only licensed live Bacille Calmette-Guérin (BCG) vaccine used to prevent severe childhood tuberculosis comprises genetically divergent strains with variable protective efficacy and rates of BCG-induced adverse events. The whole-genome sequencing (WGS) allowed evaluating the genome stability of BCG strains and the impact of spontaneous heterogeneity in seed and commercial lots on the efficacy of BCG-vaccines in different countries. Our study aimed to assess sequence variations and their putative effects on genes and protein functions in the BCG-1 (Russia) seed lots compared to their progeny isolates available from immunocompetent children with BCG-induced disease (mainly, osteitis).

Results
Based on the WGS data, we analyzed the links between seed lots 361, 367, and 368 used for vaccine manufacture in Russia in different periods, and their nine progeny isolates recovered from immunocompetent children with BCG-induced disease. The complete catalog of variants in genes relative to the reference genome (GenBank: CP013741) included 4 synonymous and 8 nonsynonymous single nucleotide polymorphisms, and 3 frameshift deletions. Seed lot 361 shared variants with 2 of 6 descendant isolates that had higher proportions of such polymorphisms in several genes, including ppsC, eccD5, and eccA5 involved in metabolism and cell wall processes and reportedly associated with virulence in mycobacteria. One isolate preserved variants of its parent seed lot 361 without gain of further changes in the sequence profile within 14 years.

Conclusions
The background genomic information allowed us for the first time to follow the BCG diversity starting from the freeze-dried seed lots to descendant clinical isolates. Sequence variations in several genes of seed lot 361 did not alter the genomic stability and viability of the vaccine and appeared accumulated in isolates during the survival in the human organism. The impact of the observed variations in the context of association with the development of BCG-induced disease should be evaluated in parallel with the immune status and host genetics. Comparative genomic studies of BCG seed lots and their descendant clinical isolates represent a beneficial approach to better understand the molecular bases of efficacy and adverse events during the long-term survival of BCG in the host organism.
Systematic characterization of the branch point binding protein, splicing factor 1, gene family in plant development and stress responses
Authors: Zhang Kai-Lu , Feng Zhen , Yang Jing-Fang , Yang Feng , Yuan Tian , Zhang Di , Hao Ge-Fei , Fang Yan-Ming , Zhang Jianhua , Wu Caie , Chen Mo-Xian , Zhu Fu-Yuan 
Published: August 2020

Abstract
Background
Among eukaryotic organisms, alternative splicing is an important process that can generate multiple transcripts from one same precursor messenger RNA, which greatly increase transcriptome and proteome diversity. This process is carried out by a super-protein complex defined as the spliceosome. Specifically, splicing factor 1/branchpoint binding protein (SF1/BBP) is a single protein that can bind to the intronic branchpoint sequence (BPS), connecting the 5′ and 3′ splice site binding complexes during early spliceosome assembly. The molecular function of this protein has been extensively investigated in yeast, metazoa and mammals. However, its counterpart in plants has been seldomly reported.

Results
To this end, we conducted a systematic characterization of the SF1 gene family across plant lineages. In this work, a total of 92 sequences from 59 plant species were identified. Phylogenetic relationships of these sequences were constructed, and subsequent bioinformatic analysis suggested that this family likely originated from an ancient gene transposition duplication event. Most plant species were shown to maintain a single copy of this gene. Furthermore, an additional RNA binding motif (RRM) existed in most members of this gene family in comparison to their animal and yeast counterparts, indicating that their potential role was preserved in the plant lineage.

Conclusion
Our analysis presents general features of the gene and protein structure of this splicing factor family and will provide fundamental information for further functional studies in plants.