bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elevated Serum Total Bile Acid Level at Second Trimester Increases the Risk of Gestational Diabetes Mellitus and Adverse Perinatal Outcomes in Chinese Pregnant Women
Authors: Liu Yao , Li Yan , Chen Hengying , Sun Ruifang , Wei Yuanhuan , Wang Nuoya , Deng Guifang , Zhang Zheqing 
Published: September 2020

Abstract
BackgroudBile acid metabolism is reported to be closely involved in glycolipid metabolism. We investigated the association of the total bile acid (TBA) levels at the second trimester with the risk of gestational diabetes mellitus (GDM) and adverse perinatal outcomes.MethodsWe performed a retrospective cohort study in 2773 Chinese pregnant women. Serum TBA level was measured by a biochemistry automatic analyzer. Logistic regression models with or without restricted cubic splines were performed.Results652 of 2773 pregnant women developed GDM. Women with GDM had higher serum TBA levels at the second trimester than that of healthy women (P < 0.001). Elevated serum TBA levels at the second trimester were associated with an increased risk of GDM in a dose-response manner. After the adjustment of age, BMI, smoking and drinking status, education background, lipid profiles, blood pressure, liver function, uric acid, bilirubin, urea nitrogen and creatinine, the odds ratios (ORs) of GDM for the highest (vs. the lowest) quartile were 1.83 (95% CI 1.10–3.38) in women. The inclusion of TBA levels at the second trimester in the model increased the area under the curve from 0.68 to 0.72 (95% CI: 0.68–0.76) (P < 0.05). Additionally, a higher serum TBA level was associated with higher odds of preterm birth (the highest quartile vs. the lowest quartile, AOR 1.91, 95% CI 1.26–2.98, P-trend = 0.017) and preeclampsia (the highest quartile vs. the lowest quartile, AOR 2.07, 95% CI 1.19–3.63, P-trend = 0.002). Furthermore, the U-shaped relationship was observed between TBA levels and the risk of premature rupture of membranes, with the lowest risk in the TBA concentration of 3.14 µmol/L.ConclusionWomen with higher fasting serum TBA levels at the second trimester have higher risk for development of GDM, preterm birth and preeclampsia.
Investigating the Effect of Near Infra-red Spectroscopy (NIRS) on Early Diagnosis of Cardiac Surgery Associated Acute Kidney Injury
Authors: zadeh Fatemeh Javaherforoosh , Bhandori Hojatolah , Jarirahmadi Sara , Bakhtiari Nima 
Published: September 2020

Abstract
Background. Cardiac surgery-associated acute kidney injury (CSA –AKI), is a major complication of cardiac surgery. Early detection of this complication can improve the quality of post-operative care and help to prevent this phenomenon.Materials and Methods: 148 patients were enrolled to study and 107 patients were selected for analysis between February and September 2019 in the cardiac surgery unit of Golestan Hospital. Ahvaz. Iran. Kidney tissue oxygen saturation was measured in multiple definite times during surgery. Hemoglobin, blood urea nitrogen, creatinine, and lactate were measured during and 48 hours after surgery.Results: Forty-one patients were diagnosed of CSA-AKI according to KDIGO criteria. Parametric and non-parametric analyzes significant difference was not detected between CSA-AKI and NON CSA-AKI group in the demographic parameter. Repeated measurement of ANOVA Analysis did not show any significant difference in parameters except for BUN. Repeated measurement of ANOVA showed a significant difference in both groups and time factors (p<0.001, p=0.0006 respectively). ROC curve analyzes showed in a single point of time, difference the middle of CPB time from baseline high-value in the prediction of AKI 0.764 (0.57 to 0.951) (AUC-CI). Conclusion; Kidney saturation monitoring could be considered as routine monitoring in cardiac surgery for the rapid detection of CSA -AKI. Although kidney tissue saturation is not correlated directly to the arterial saturation of oxygen, physician and surgery team could predict the chance of acute kidney injury exposure.
Longitudinal Use of the Consolidated Framework for Implementation Research to Evaluate the Creation of a Rural Center of Excellence in Transgender Health
Authors: Tinc Pamela Jane , Wolf-Gould Christopher , Wolf-Gould Carolyn , Gadomski Anne 
Published: September 2020

Abstract

BackgroundTransgender people face numerous barriers to accessing care, particularly in rural settings. Transportation, travel time, a lack of providers offering transgender care, and discrimination all contribute to these barriers. The Gender Wellness Center was established to fill a gap in rural transgender care, and was subsequently awarded a Robert Wood Johnson Foundation grant to establish a Center of Excellence. This study examines the implementation of the Center of Excellence, a complex intervention, over the course of 18 months.MethodsThe Consolidated Framework for Implementation Research was used to develop baseline and follow-up surveys. These were distributed to members of the core implementation team at the Gender Wellness Center at the midpoint and conclusion of the Robert Wood Johnson Foundation grant. Responses were largely open-ended and analyzed qualitatively.ResultsResults are presented in terms of Consolidated Framework domains and constructs, as well as the relative outlook (positive or negative) of implementation. Overall, there were improvements over time, with more encouraging feedback and examples of success at follow-up. Though true, organizational culture and individual beliefs about the provision of transgender care challenged implementation of the Center of Excellence throughout the project.ConclusionsThis study highlights the importance of organizational culture on implementation efforts, as well as the need for complex, multi-faceted interventions to overcome such challenges in order to improve care for marginalized populations.Trial registrationNot applicable
A Long-Term Control Study of the Treatment of Cervical Radiculopathy by Percutaneous Endoscopic Posterior Cervical Discectomy and Anterior Cervical Decompression, Bone Graft Fusion and Internal Fixation
Authors: Huang Xiaodong , Wang Weiheng , Meng Qingxi , Yu Jiangming , Ye Xiaojian 
Published: September 2020

Abstract
BackgroundCervical spondylotic radiculopathy (CSR) is very common all over the world. However, there are only a few reports about the efficacy of percutaneous endoscopic posterior cervical discectomy (PEPCD) in the treatment of CSR. Anterior cervical decompression and fusion (ACDF) and PEPCD which is a better way to treat CSR need further study.MethodsFrom January 2015 to December 2016. A retrospective study of 70 patients undergoing surgery for CSR (33 using PEPCD and 37 using ACDF). The intra-operative parameters, neck disability index (NDI), neck and arm visual analog scale (VAS) score were used to assessed clinical outcome. Radiological outcomes were assessed by measuring cervical 2-7 (C2-7) lordosis, disc height index (DHI), and degree of degenerative changes at the corresponding level.ResultsThe mean follow-up period was 48.5 month (36 –66 months). Two groups can significantly improve the clinical symptoms. There was no significant difference between the two groups in clinical results (VAS, NDI). Compared with preoperative, the lordosis of C2-7 increased significantly at the last follow-up. At the last follow-up, C2-7 lordosis in the ACDF group was significantly higher than that in the PEPCD group. In PEPCD, compared with preoperative, there was no significant difference in the DHI, but the degree of disc degeneration was significantly increased at the last follow-up.ConclusionFor patients with CSR, PEPCD had similar clinical early and intermediate outcomes when compared with ACDF, with the advantages of minimally invasive. PEPCD is a sufficient and safe supplement and alternative to conventional surgery.
Numerical Simulation of Transient Cavitation Characteristics of Valve-Controlled Liquid-Filled Hydrodynamic Coupling
Authors: Cui Hongwei , Zhang Jiahua , Wang Guoqiang 
Published: September 2020

Abstract
In high-power impeller industries, valve-controlled liquid-filled hydrodynamic couplings are widely used in the soft startup of heavy-duty scraper conveyors for mining. However, the water circulation speed in internal flow fields is higher at lower speed ratios, making the hydrodynamic couplings prone to severe cavitation, which further results in severe performance degradation, noise, vibration, or even erosion failure. Meanwhile, because a hydrodynamic coupling is a piece of closed-loop multicomponent turbomachinery, internal transient cavitation flow behavior cannot be easily controlled. To reasonably predict the characteristics of cavitation and its influence on the working performance of the hydrodynamic coupling, a high-quality structured mesh model of the internal flow field for an impeller was established. Considering the periodic structural characteristics of the impeller, a scale-resolving simulation turbulence model was combined with a Rayleigh–Plesset cavitation model to establish a single-cycle hydrodynamic coupling calculation model. The cavitation distribution characteristics and torque transmission of the flow field under different working conditions were obtained, and the effect of cavitation on the soft startup performance was analyzed. The results demonstrated that cavitation in the hydrodynamic coupling mainly occurred under low speed ratios. The degree of cavitation decreased as speed ratio increased. The worst-case scenario for cavitation occurred when the speed ratio was zero. Most of the cavitation bubbles were generated at the tip of the blades, resulting in unstable variation in torque characteristics and deterioration of the working performance of the hydrodynamic coupling. The analysis reveals that the cavitation process in the impeller is highly unstable and periodic, and the cavitation development near the tip of the blades occurs in four stages: birth, growth, separation, and disintegration. The generated steam accumulates in the inner ring of the impeller. Therefore, a method for accurately predicting the cavitation characteristics of hydrodynamic couplings based on high-precision technology is proposed, and a theoretical basis for coupling design and cavitation suppression technology is provided.
The Effect of a Decision-Support mHealth Application on Maternal and Neonatal Outcomes in Two District Hospitals in Rwanda: Quasi-Experimental Study
Authors: Nishimwe Aurore , Ibisomi Latifat , Nyssen Marc , Conco Daphney Nozizwe 
Published: September 2020

Abstract
Background: Globally, mobile health (mHealth) applications are known for their potential to improve healthcare providers’ access to relevant and reliable health information. Besides, electronic decision support tools, such as the Safe Delivery mHealth Application (SDA), help to reduce clinical errors and to ensure quality care at the point of service delivery. The current study assessed the effects of the SDA on basic emergency obstetric and newborn care (BEmONC) outcomes for the most frequent complications in Rwanda; post-partum haemorrhage (PPH) and newborn asphyxia and its complications.Methods: The study adopted a quasi-experimental design. A pre-intervention record review of the BEmONC outcomes: Apgar score and PPH progressions, was conducted. The intervention took place in two district hospitals in Rwanda and entails the implementation of the SDA for six months. Six months’ post-intervention, the effect of the SDA on BEmONC outcomes was evaluated. The study included 327 participants (114 cases of PPH and 213 cases of neonatal complications). The analysis compared the outcome variables between the baseline and the endline data. Fisher’s exact test was used to compare the proportions and test between-group differences and significance level set at p<0.05. Results: Unstable newborn outcome following neonatal resuscitation was recorded in 61.90% and 27.59% newborns cases at baseline and endline respectively, P-value = 0.000. Unstable maternal outcome following PPH management was recorded in 19.40 % and 6.38% maternal cases at baseline and endline respectively, P-value = 0.048. There was a significant association between the SDA intervention and newborns’ and maternal’ outcomes following neonatal resuscitation and PPH management, 6 months after baseline.Conclusion: The use of the SDA supported nurses and midwives in the management of PPH and neonatal resuscitation thus improved maternal and neonatal outcomes after 6 months of the SDA intervention.
Clinical Analysis of Gastrointestinal Bleeding in Patients with Severe Coronavirus Disease (COVID-19): A Retrospective Observational Study
Authors: Dai Jinfen , Hu Song , Chen Yi , Wu Pengbo , Liu Mei 
Published: September 2020

Abstract
Background: The epidemic of Novel coronavirus disease 2019(COVID-19) has attracted the great attention of people all over the world. Gastrointestinal bleeding in patients with COVID-19 has been studied rarely. We mean to investigate the clinical characteristics of gastrointestinal bleeding in patients with severe coronavirus disease (COVID-19).Methods: Nineteen severe COVID-19 patients with gastrointestinal bleeding were retrospectively studied. Clinical data, including medical history, symptoms, laboratory characteristics, and treatment, were collected and analyzed. We also compared the characteristics of patients with different degrees of bleeding.Results: Fourteen patients (73.6%) were men. Mean age was 63.8 (±15.6) years. Most patients (89.4%) had no history of gastrointestinal bleeding. The most common presentation of gastrointestinal bleeding was a positive fecal occult blood test (15/19 cases, 78.9%). Fifteen patients (78.9%) did not require blood transfusion. Five of 15 patients (33%) received anticoagulants and antiplatelet drugs before gastrointestinal bleeding in the mild bleeding group, and 2/4 (50%) in the severe bleeding group. Four of 15 patients (27%) died in the mild bleeding group and no patients died in the severe bleeding group.Conclusions: The presentations of gastrointestinal bleeding in severe COVID-19 patients are not obvious, and frequent fecal occult blood test is needed to detect gastrointestinal bleeding early. Patients receiving anticoagulants and antiplatelet drugs need a close observation for gastrointestinal bleeding. Gastrointestinal bleeding may not increase the mortality, after giving blood transfusion support therapy.
Prognostic Role of TLE Family in Lung Adenocarcinoma
Authors: Ma Qianli , Xiao Fei , Xing Huajie , Song Zhiyi , Zhang Jin , Si Chaozeng , Liang Chaoyang 
Published: September 2020

Abstract
Background Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer death worldwide. Lung adenocarcinoma (LUAD) is the most common type of lung cancer. Transducin-like Enhancer of split (TLE) family proteins repress transcription by multiple mechanisms. The prognostic role of TLEs in LUAD is still unclear. Methods We took TCGA dataset to analyze the relationship between the expression of TLEs and LUAD outcome. Results The expression of TLEs were different between 59 normal and 513 tumor samples. High TLE1 and low TLE2 were associated with poor PFS and OS (all p＜0.050). Multivariate analysis demonstrated that high TLE1 and low TLE2 were independent risk factors. Moreover, the combination of TLE1 and TLE2 was a better tool in prognostication. Conclusions High TLE1 and low TLE2 expressions are independent adverse prognostic factors and can be used as prognostic biomarkers in LUAD.
miR155 Enhances Autophagy by Reducing MBD5 and METTL3 in Human Liver Cancer Stem Cells
Authors: Lu Yanan , Chen Yingjie , Xin Xiaoru , Song Shuting , Jiang Xiaoxue , Xie Sijie , Wang Liyan , Lu Dongdong 
Published: September 2020

Abstract
Background: miR-155 is a widely reported carcinogenic miRNA, with up-regulated expression in a variety of human cancers. Methods: Liver cancer stem cells were isolated from Huh7 cells; gene infection, RT-PCR, Western blotting and tumorigenesis test in vitro and in vivo were performed to analyze the signaling pathway. Results: we demonstrate that miR-155 inhibits the expression of MBD5 and METTL3 , reducing the expression of DNMT1. In particular, miR155 inhibits the interaction between MBD5 and DNMT1, thereby inhibiting the binding capacity among MBD5, DNMT1 and IGFII (H19 ICR, IGFII DMR, IGFII Enhancer) DNA, inhibiting IGFII DNA methylation modification. Importantly, miR-155 promotes the formation of DNA loops in the IGFII DNA region (H19 ICR-IGFII Enhancer, IGFII DMR-IGFII Enhancer). Therefore, miR155 promotes the binding ability of H19-pre miR675 to histone methyltransferases SUV39h2 dependent on the H19 ICR-IGFII enhancer DNA loop and enhances the methylation modification of histone H3 on the ninth lysine . Then, the binding ability of RNA polII to P300 was enhanced by the formation of H3K9me2-RNA polII-P300 complex. Furthermore, miR155 promotes the binding ability of the RNA PolII-P300 complex to the IGFII promoter dependent on the IGFII DMR-IGFII enhancer DNA loop and promotes the expression of IGFII. Further research shows that miR155 promotes the binding of IGFII to stemness factors and the loading of stemness factors into the promoter region of HGF, which promotes the expression of hepatocyte growth factor HGF. In particular, miR155 promotes the expression of albumin gene (ALB) via HGF-c-MET, and then promotes the Sirt1 expression through ALB. Strikingly, miR155 promotes the autophagy dependent on acetylase Sirt1,including that miR155 promotes LC3 activation dependent on acetylase sirt1 and enhances binding capacity of LC3 to TP53INP2 / DOR, ATG4, ATG3 and ATG7, and the binding ability of the interaction between ATG5, ATG12, ATG6L1, ATG9. More meaningfully, miR155 enhances the ability of H-Ras to bind to the autophagosomes Beclin1, vps34, vps5, Uvrage, bif1, Lamp1, Lamp2, Lamp3, Rubicon, Rab24 dependent on autophagy, thereby enhancing the expression of H-Ras. Furthermore, miR155 enhances the expression of pRaf1, pMEK1 / 2, pERK1 / 2, pElK, pJak, Jun, pAKT, pmTOR, P70S6K, 4E-BP1, SGK1, C-myc dependent on H-Ras.Finally, miR-155 promotes the malignant growth of human liver cancer stem cells mediated by H-Ras.Conclusions: these results provide a valuable theoretical basis for therapeutic targets of liver cancer based on miR-155.
Bibliometric Study of the Most Influential 100 Publications in Vertebral Augmentation Research
Authors: WANG Shuang , JI Nan , WANG Shuai , FU Yu-ping , WANG Hai-zhou , YU Zhuo-li 
Published: September 2020

Abstract
Purpose A bibliometric study was conducted to identify and analyze the most influential 100 publications in vertebral augmentation research.Methods Databases of Web of Science and Pubmed were searched using the key words of ‘percutaneous vertebroplasty’, ‘percutaneous kyphoplasty’, ‘balloon kyphoplasty’, ‘vertebroplasty’, ‘kyphoplasty’ and ‘vertebral augmentation’. The searched publications were arranged by the times of cited per year after excluding the papers not associated with vertebral augmentation closely. The top 100 publications were defined as the most influential papers in this field and analyzed. Collecting data included the journal, the year of publication, the nation of the Corresponding author, the total times of citation, the citation times per year since publication, and the study type of the papers. The evidence levels of the clinical studies were graded between I to V. The systemic reviews and meta-analyses were combined as a specific type.Results The total citation times of the 100 publications were 27222 and they were cited 18.3 times per year in average. These papers were published in 31 journals in which 13 kinds of journals published more than 2 papers. Corresponding authors came from 17 different nations in which the American authors were the most. The level IV evidence studies were the most as 41 and only 3 papers reached the standards of level I evidence study. The number of the publications decreased obviously after 2009, in which year the two level I evidence publications were published.Conclusion There are still contrary opinions about vertebral augmentation now even after the publications of the two authoritative studies of level I evidence. New studies should be developed with more deliberated design and longer follow-up, meanwhile the patients should be selected more cautious and the evaluation factors should be included more extensively.
One Percutaneous Portal Endoscopic Discectomy in the Treatment of Two-Level Lumbar Disc Herniations Patients with Leg Pain and Numbness
Authors: Yan Denglu , Zhang Zaiheng , Zhang Zhi 
Published: September 2020

Abstract
Background: Although minimally invasive has been adopted in the treatment of lumbar disc herniation, there were no studies in literature of two-level lumbar disc herniations patients with leg pain and numbness treatment by one portal percutaneous endoscopic procedures. The purpose of this study was to evaluate the efficacy of one percutaneous portal transforaminal endoscopic lumbar discectomy techniques in the treatment of two-level lumbar disc herniations patients with leg pain and numbness. Methods: A total of 98 patients of two-level lumbar disc herniations who had one portal endoscopic surgery were categorized into two groups depending on the level number of endoscopic procedures. There were 51 patients had leg pain and leg numbness (A group), and 47 patients with leg pain (B group). One portal percutaneous endoscopic discectomy procedures were performed and the clinical outcomes were recorded. Results: The entry point of two levels disc herniations is planned by parallel to the plane of the proximal disc level and target to the site of distal disc herniation. The procedures in two levels disc herniations was performed beginning at proximal level in L3/4 with L4/5 herniation and distal level in L4/5 with L5/S1. There were no nerve root injury and dural tear of cerebrospinal fluid leakage complications. The postoperative disk and foramen height were no significant difference compare to preoperative in all patients (P > 0.05), and no significant difference between two groups (P > 0.05). The pain index and Oswestry Disability Index score were better than preoperational in all patients, and no significant difference between two groups (P > 0.05). The central disc herniation patients had more leg numbness than lateral disc herniation patients (P < 0.01). For patients with leg pain and leg numbness, the leg numbness release in lateral disc herniation patients were better than central herniation patients, and leg numbness dismissed were 6 months post-operation in lateral herniation patients and 12 months post-operation in central herniation patientsConclusions: Although two-level disc herniation present a significant challenge for spinal surgeon when adopted single portal techniques of endoscopic discectomy, one percutaneous portal transforaminal endoscopic lumbar discectomy was safe and minimally invasive techniques with faster recovery. For patients with leg pain and leg numbness, the central disc herniation patients had more leg numbness than lateral disc herniation patients, and the leg numbness release in lateral disc herniation patients were better than central herniation patients.