bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors impacting international‐indexed publishing among Vietnamese educational researchers
Authors: Trinh Thao‐Phuong‐Thi , Tran Trung , Le Hien‐Thu‐Thi , Nguyen Tien‐Trung , Pham Hiep‐Hung 
Published: August 2020

AbstractDespite several initiatives and policies that boost international‐indexed publishing, the outputs of social sciences in general and educational science of Vietnam in international academic databases such as Clarivate Web of Science (WoS) or Scopus are still modest. This study examined the factors affecting international‐indexed publishing among Vietnamese educational researchers. A framework for determining the influential factors was developed comprising three dimensions (policies, capacities, and networking) with 15 sub‐factors, and the Analytic Hierarchy Process (AHP) model was employed to estimate the relative importance of these factors on international publishing. A survey of Vietnamese educational researchers at higher education and research institutes was undertaken, of which 80 returned validated answers, which after analysis were reduced to 49. The study revealed that the most important factors were collaboration with domestic and international peers and receiving support from research assistants or supervisors. A closer investigation revealed differences between senior and junior researchers regarding issues such as the accessibility of scientific documents, research data, and time for research.Key points
There are greater STEM than HSS outputs from Vietnam, although the growth of social science output is growing at a faster rate.
Both senior and junior Vietnamese educational researchers agree that local and international networking is a major factor in successful publication within internationally indexed journals.
Junior educational researchers identify available time for research as a major limiting factor in international publication where it is not identified as such by senior researchers.
Capacity‐related factors for successful publication are perceived as less limiting than policy or networking factors among Vietnamese researchers.
Clinical characterization and hematopoietic stem cell transplant outcomes for congenital sideroblastic anemia caused by a novel pathogenic variant in SLC25A38
Authors: Uminski Kelsey , Houston Donald S. , Hartley Jessica N. , Liu Jing , Cuvelier Geoffrey D.E. , Israels Sara J. 
Published: August 2020

AbstractBackgroundCongenital sideroblastic anemia (CSA) constitutes an uncommon category of inherited anemia often associated with pathologic iron accumulation. Pathogenic variants in several genes have been identified as causative for CSA. Autosomal recessive pathogenic variants in the mitochondrial glycine transporter SLC25A38 have been implicated in a subset of patients with CSA.ProcedureWe describe seven individuals of Canadian Cree descent with a known or inferred homozygous novel founder missense variant in SLC25A38 (c.560G>A, p.Arg187Gln).ResultsAll individuals presented as young children (median age 6 months) with severe microcytic, hypochromic anemia associated with pretransfusion iron overload, requiring red cell transfusion support and iron chelation. Six individuals received pyridoxine supplementation; two demonstrating transient partial responses. Three individuals underwent allogeneic hematopoietic stem cell transplantation (HSCT). One individual with significant iron loading died in the posttransplant period due to complications of sepsis. The other two individuals remain transfusion‐free following HSCT.ConclusionsDespite a common genetic etiology, phenotypic variability was noted in this cohort. A transient response to pyridoxine was noted in two individuals but should not be considered a long‐term therapeutic strategy. HSCT was curative when performed before significant iron loading occurred. Early identification of CSA and timely HSCT can result in excellent long‐term outcomes.
Conjugated‐carbon nanostructures: Emergences
Authors: Klein Douglas J. , Ortiz Yenni P. , Bytautas Laimutis 
Published: August 2020

AbstractGeneral emergent features of conjugated‐carbon nanostructures are sought. Here, “general” indicates applicability over a broad class of such structures, including graphene and buckytubes, possibly with boundaries or other sorts of defects or decorations, or rather general substructures of graphene or of buckytubes. In addition, “emergent” means that different characteristics and properties are novel and are evidenced from different models, for example, from resonance theory and Hückel theory, preferably with evidence that the features persist upon elaboration. One robust emergent feature is “Dirac cones” in the band structure of graphene and some related materials. Another interesting feature is novel “blended” boundary orbitals that are delocalized longitudinally along the boundary direction while being variably localized in the transverse direction. Furthermore, defects at the ends of polymer chains may be localized or delocalized depending on local features—although the ideas apply more widely to different conjugated‐carbon structures including molecules. Explicit formulas are derived to elucidate the asymptotic behavior of unpaired electron density at the ends of selected benzenoid polymers and its relation to the associated HOMO‐LUMO gap. Our approach offers a general framework to understand ab initio results, which may, at first sight, appear to be unconventional or counterintuitive to some common ideas of bonding patterns in conjugated carbon nanostructures.
Theoretical exploration on the vibrational and mechanical properties of M3C2/M3C2T2 MXenes
Authors: Luo Kan , Zha Xian‐Hu , Zhou Yuhong , Huang Qing , Zhou Shenghu , Du Shiyu 
Published: August 2020

AbstractMXenes have attracted intensive attention in chemistry and material science for their special structures and properties. In order to understand the basic physical properties of the M3C2/M3C2T2 (MSc, Ti, V, Cr, Zr, Nb, Mo, Hf, Ta, W; TF, O, OH) MXenes, first‐principles calculations are carried out to investigate the structural, vibrational, and mechanical properties in this work. Both the metal atoms and surface groups can significantly influence the configurations or mechanical behaviors of the MXenes. The dehydrogenation tendency is calculated to evaluate the possible forms of the M3C2(OH)2 toward M3C2O2. The work functions of MXenes functionalized by different groups are compared, and the lower work functions for the OH functionalized ones, which can be as low as 1.358 eV for the Sc3C2(OH)2, suggest potential good performance in electron emission. In addition, the stability, mechanical properties, and the Raman and infrared (IR) activity modes of the MXenes are reported. Generally, functionalized MXenes would present smaller lattice parameters, lower free energies, and stronger mechanical strength compared to their counterparts. The data obtained may provide important theoretical ground for the investigations of the applications of MXenes.
Undergraduate degrees that train students for soil science careers at universities in the USA and its territories
Authors: Brevik Eric C. , Dolliver Holly , Edinger‐Marshall Susan , Itkin Danny , Johnson‐Maynard Jodi , Liles Garrett , Mbila Monday , Moorberg Colby , Sanchez‐de Leon Yaniria , Steffan Joshua J. , Ulery April , Vaughan Karen 
Published: August 2020

AbstractSeveral soil science education studies over the last 15 yr have focused on the number of students enrolled in soil science programs. However, no studies have quantitatively addressed the number of undergraduate soil science preparatory programs that exist in the United States, which means we do not have solid data concerning whether overall program numbers are declining, rising, or holding steady. This also means we do not have complete data on the same trends for total undergraduate soil science students in the United States. This study used the US Office of Personnel Management (OPM) Soil Science Series 0470 standards to determine if a bachelor's degree met soil science preparatory criteria. Lists of the approximately 3,500 regionally accredited colleges and universities were obtained from the regional accrediting agencies; the website of each of the colleges and universities was visited to determine if they had a degree program that met the OPM 0470 criteria. Ninety‐two soil science preparatory degree programs were identified at 86 colleges and universities. These programs were primarily linked to (a) agriculture, (b) environmental science, and (c) soil and water science, based on the number of degree occurrences. This study creates a baseline for future studies that can investigate trends in soil science programs. It also provides an insight into the institutions and degree programs that should be included in soil science education studies.
Suppression of inflammation and fibrosis using soluble epoxide hydrolase inhibitors enhances cardiac stem cell-based therapy
Authors: Sirish Padmini , Thai Phung N. , Lee Jeong Han , Yang Jun , Zhang Xiao-Dong , Ren Lu , Li Ning , Timofeyev Valeriy , Lee Kin Sing Stephen , Nader Carol E. , Rowland Douglas J. , Yechikov Sergey , Ganaga Svetlana , Young Nilas , Lieu Deborah K. , Yamoah Ebenezer N. , Hammock Bruce D. , Chiamvimonvat Nipavan 
Published: August 2020

Abstract
Stem cell replacement offers a great potential for cardiac regenerative therapy. However, one of the critical barriers to stem cell therapy is a significant loss of transplanted stem cells from ischemia and inflammation in the host environment. Here, we tested the hypothesis that inhibition of the soluble epoxide hydrolase (sEH) enzyme using sEH inhibitors (sEHIs) to decrease inflammation and fibrosis in the host myocardium may increase the survival of the transplanted human induced pluripotent stem cell derived-cardiomyocytes (hiPSC-CMs) in a murine postmyocardial infarction model. A specific sEHI (1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea [TPPU]) and CRISPR/Cas9 gene editing were used to test the hypothesis. TPPU results in a significant increase in the retention of transplanted cells compared with cell treatment alone. The increase in the retention of hiPSC-CMs translates into an improvement in the fractional shortening and a decrease in adverse remodeling. Mechanistically, we demonstrate a significant decrease in oxidative stress and apoptosis not only in transplanted hiPSC-CMs but also in the host environment. CRISPR/Cas9-mediated gene silencing of the sEH enzyme reduces cleaved caspase-3 in hiPSC-CMs challenged with angiotensin II, suggesting that knockdown of the sEH enzyme protects the hiPSC-CMs from undergoing apoptosis. Our findings demonstrate that suppression of inflammation and fibrosis using an sEHI represents a promising adjuvant to cardiac stem cell-based therapy. Very little is known regarding the role of this class of compounds in stem cell-based therapy. There is consequently an enormous opportunity to uncover a potentially powerful class of compounds, which may be used effectively in the clinical setting.

Significance statement Stem cell replacement offers a great potential for cardiac regenerative therapy. However, there is a significant loss of transplanted stem cells from ischemia and inflammation in the host environment. This study demonstrates beneficial effects of inhibitors of soluble epoxide hydrolase (sEHI) in cell-based therapy using human induced pluripotent stem cell-derived cardiomyocytes in a preclinical model. sEHI results in a significant increase in the retention of transplanted stem cells and an improvement in cardiac function. Very little is known regarding this class of compounds in cell-based therapy. There is consequently an opportunity to uncover a potentially powerful class of inhibitors, which may be used in clinical settings.
Are the Sustainable Development Goals really sustainable? A policy perspective
Authors: Jain Prerna , Jain Pragati 
Published: August 2020

AbstractSustainable development seeks human well‐being without stretching the ecological limits. It is assumed that if sustainable development is aspired at global level, the goals prescribed should be within the planetary limits. A comparison of the scores of countries with respect to Sustainable Development Goal Index (SDGI) and scores on Ecological Footprints (EF) portrays quite a grim picture where countries with high EF have attained high scores on SDGI. A further investigation into the causal relationship between SDGI, Human Development Index (HDI) and EF reveals that SDGs are being achieved in an unsustainable manner. The environmental policy perspective of the total, direct and indirect effects of EF on SDGs estimated through path analysis unveils that the existing mode of achieving SDGs is at the cost of environmental degradation. SDGs have shown improvement through the improvement in the level of HDI, where human development is being attained in an environmentally unsustainable manner. The paper establishes that SDGs achieved are ecologically unjustifiable, and a reorientation of the existing patterns of human development well within the limits of ecological capacity of the earth is to be targeted.
Structure–Activity Relationship Study of T1R2/T1R3 Positive Allosteric Modulators and Evaluation of Their Enhancing Effect on Various Sweeteners
Authors: Matsumoto Ryo , Yamada Kei , Nakazawa Masakazu , Mori Suguru , Kitajima Seiji 
Published: August 2020

AbstractThe sweet taste receptor T1R2/T1R3 belongs to the family of G protein coupled receptors and recognizes various sweet substances from small compounds to proteins. We have previously reported unnatural tripeptides that function as positive allosteric modulators (PAMs) of the T1R2/T1R3. The structures were classified into three parts—head, linker, and tail—as compared with known T1R2/T1R3 PAMs. Here, we conducted a structure–activity relationship study of the tail structure to further understand the structural features of the T1R2/T1R3 PAMs. Moreover, we evaluated the enhancing effect of these PAMs on various sweeteners. In conclusion, we found that both hydrophilic α‐amino acids and the hydrophobicity of the α‐amino acid side chain are important for enhancing activity for this receptor. These PAMs also showed the receptor enhancing activity against sugar‐like T1R2/T1R3 agonists such as sucrose, sucralose, and fructose.
Thrombolytic Agents: Nanocarriers in Controlled Release
Authors: Hassanpour Soodabeh , Kim Han‐Jun , Saadati Arezoo , Tebon Peyton , Xue Chengbin , van den Dolder Floor W. , Thakor Jai , Baradaran Behzad , Mosafer Jafar , Baghbanzadeh Amir , de Barros Natan Roberto , Hashemzaei Mahmoud , Lee Kang Ju , Lee Junmin , Zhang Shiming , Sun Wujin , Cho Hyun‐Jong , Ahadian Samad , Ashammakhi Nureddin , Dokmeci Mehmet R. , Mokhtarzadeh Ahad , Khademhosseini Ali 
Published: August 2020

AbstractThrombosis is a life‐threatening pathological condition in which blood clots form in blood vessels, obstructing or interfering with blood flow. Thrombolytic agents (TAs) are enzymes that can catalyze the conversion of plasminogen to plasmin to dissolve blood clots. The plasmin formed by TAs breaks down fibrin clots into soluble fibrin that finally dissolves thrombi. Several TAs have been developed to treat various thromboembolic diseases, such as pulmonary embolisms, acute myocardial infarction, deep vein thrombosis, and extensive coronary emboli. However, systemic TA administration can trigger non‐specific activation that can increase the incidence of bleeding. Moreover, protein‐based TAs are rapidly inactivated upon injection resulting in the need for large doses. To overcome these limitations, various types of nanocarriers have been introduced that enhance the pharmacokinetic effects by protecting the TA from the biological environment and targeting the release into coagulation. The nanocarriers show increasing half‐life, reducing side effects, and improving overall TA efficacy. In this work, the recent advances in various types of TAs and nanocarriers are thoroughly reviewed. Various types of nanocarriers, including lipid‐based, polymer‐based, and metal‐based nanoparticles are described, for the targeted delivery of TAs. This work also provides insights into issues related to the future of TA development and successful clinical translation.
Expression of xenobiotic metabolising enzymes in lungs of horses with or without histological evidence of lower airway inflammation
Authors: Löfgren Maria , Larsson Pia , Lindberg Ronny , Hörnaeus Katarina , Tydén Eva 
Published: August 2020

AbstractMild, moderate and severe equine asthma is a problem for equine welfare. The aetiology of the disease is not known in detail but is likely multi‐factorial. One important factor may be inhaled dust which carries harmful substances which may be bioactivated and thus can lead to local inflammation in the airways. The aim of this study was to investigate gene expression and protein localisation of cytochrome P450 (CYP) enzymes, superoxide dismutase and glutathione‐S‐transferases (GST) involved in bioactivation and detoxification of harmful substances in lungs of horses with or without histological evidence of lower airway inflammation. Significantly lower gene expression of CYP2A13 and GSTM1 was observed in lungs from horses with histological evidence of lower airway inflammation compared with horses without. A higher expression, although not significant, was found for CYP1A1 in horses with histological evidence of lower airway inflammation. There were no differences in gene expression of GSTP1 and SOD3. The proteins were localised in the respiratory epithelium which is of relevance as a defence to local exposure of inhaled harmful substances. In conclusion, our study reports differential gene expression of enzymes involved in bioactivation and detoxification of foreign substances in the lungs of horses with histological evidence of lower airway inflammation compared with horses without.
Sero‐epidemiology investigation of Coxiella burnetii in domestic ruminants throughout most Greek regions
Authors: Vourvidis Dimitrios , Kyrma Anna , Linou Maria , Edouard Sophie , Angelakis Emmanouil 
Published: August 2020

AbstractQ fever is not considered as a public health problem in Greece where most regions are considered as Coxiella burnetii free possibly because of the low interest for this agent. Our objective was to conduct a large‐scale study to investigate the sero‐epidemiology of C. burnetii in domestic ruminants throughout the most of Greek regions. We tested serum samples obtained from goats, sheep and bovines from different regions of Greece. All sera were tested for C. burnetii IgG antibodies by a commercial ELISA according to the manufacturer's recommendations. We tested 1,173 goats and sheep obtained from 177 different herds and totally 194 (17%) animals from 78 (44%) herds were positive for C. burnetii. Positive animals were present in seven (88%) different regions and seropositivity varied widely among these regions. The highest percentage was observed in Peloponnese (44%), where all the tested herds presented animals with C. burnetii antibodies. Ιn all Aegean Islands except the island of Limnos we detected goats and sheep positive for C. burnetii with seroposivity varying between 2% in Kos to 37% in Rhodes. Finally, in 22 (85%) Greek prefectures we found C. burnetii IgG‐positive animals whereas in 14 (54%) prefectures more than 50% of tested herds had seropositive animals. We also tested 28 cows from five different herds in Macedonia and Aegean Islands and six (21%) of them, obtained from two (40%) herds were positive. Considering the importance of C. burnetii for public health, our data reflect the lack of awareness by veterinarians, physicians and competent authorities as we provide evidence of C. burnetii seropositivity in productive animals throughout the most of Greek territories. Due to the increased risk of inhalation of the bacterium by people who entered the affected farms we raise the question of Q fever emergence in Greece.
Cover Image
Authors: Quemener Anaïs M. , Bachelot Laura , Forestier Anne , Donnou‐Fournet Emmanuelle , Gilot David , Galibert Marie‐Dominique 
Published: August 2020

The cover image is based on the Advanced Review The powerful world of ASOs: from bench to bedside by Anaïs M. Quemener et al., https://doi.org/10.1002/wrna.1594.image
Evaluation der Mikrozirkulation bei kritisch kranken Patienten
Authors: Wollborn J. , Jung C. , Göbel U. , Bruno R. R. 
Published: August 2020

ZusammenfassungFür die Aufrechterhaltung der Organdurchblutung ist eine intakte Makro- und Mikrozirkulation essentiell. Sowohl das wachsende Verständnis um die Bedeutung der Mikrozirkulation im Organversagen als auch die Möglichkeit, diese zu visualisieren, lenken die Aufmerksamkeit der Intensivmedizin auf die mikrovaskuläre Endstrombahn. Als Surrogat-Parameter sind die Rekapillarisierungszeit, der „mottling score“ und die Messung des Serum-Laktats bereits lange in der klinischen Praxis etabliert. Neuere Studien messen der Echtzeit-Darstellung der sublingualen Mikrozirkulation mittels Intravital-Videomikroskopie eine immer größere Bedeutung bei. Verschiedene Studien unterstreichen hierbei die Mikrozirkulation als prognostischen Parameter. Darüber hinaus ermöglicht die Erhebung von objektivierbaren Messwerten, diese in der Zukunft zur individuellen Therapiesteuerung weitergehend zu untersuchen.
On the Gibbons’ conjecture for equations involving the p-Laplacian
Authors: Esposito Francesco , Farina Alberto , Montoro Luigi , Sciunzi Berardino 
Published: August 2020

AbstractIn this paper we prove the validity of Gibbons’ conjecture for the quasilinear elliptic equation $$ -\Delta _p u = f(u) $$

-

Δ
p

u
=
f

(
u
)

on $$\mathbb {R}^N.$$

R

N

.

The result holds true for $$(2N+2)/(N+2)< p < 2$$

(
2
N
+
2
)
/
(
N
+
2
)
<
p
<
2

and for a very general class of nonlinearity f.
The pregnancy microbiome and preterm birth
Authors: Bayar Erna , Bennett Phillip R. , Chan Denise , Sykes Lynne , MacIntyre David A. 
Published: August 2020

AbstractPreterm birth is a global health concern and continues to contribute to substantial neonatal morbidity and mortality despite advances in obstetric and neonatal care. The underlying aetiology is multi-factorial and remains incompletely understood. In this review, the complex interplay between the vaginal microbiome in pregnancy and its association with preterm birth is discussed in depth. Advances in the study of bacteriology and an improved understanding of the human microbiome have seen an improved awareness of the vaginal microbiota in both health and in disease.
A virtual element formulation for general element shapes
Authors: Wriggers P. , Hudobivnik B. , Aldakheel F. 
Published: August 2020

AbstractThe virtual element method is a lively field of research, in which considerable progress has been made during the last decade and applied to many problems in physics and engineering. The method allows ansatz function of arbitrary polynomial degree. However, one of the prerequisite of the formulation is that the element edges have to bestraight. In the literature there are several new formulations that introduce curved element edges. These virtual elements allow for specific geometrical forms of the course of the curve at the edges. In this contribution a new methodology is proposed that allows to use general mappings for virtual elements which can model arbitrary geometries.