bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between eosinophil count and cholelithiasis among a population with Clonorchis sinensis infection in Foshan City, China
Authors: Xie W. , Deng Y. , Chen S. , Yang Q. 
Published: November 2019

Abstract
The association between eosinophil count and cholelithiasis among people with Clonorchis sinensis infection is still uncertain. We conducted a cross-sectional study to investigate the associations among Clonorchis sinensis infection, eosinophil count and cholelithiasis. The study included 4628 participants from January to December 2018. The levels of eosinophil count were divided into four groups according to the quartiles of eosinophil count. Spearman's rank correlation was performed to assess the association between eosinophil counts and Clonorchis sinensis egg counts. Multiple regression analysis was performed to evaluate the relationships among C. sinensis infection, eosinophil count and cholelithiasis after adjusting for three models. The prevalence of C. sinensis infection was 38.72% (1792/4628), and the prevalence of cholelithiasis was 6.03% (279/4628). The infection rate of C. sinensis was higher in the cholelithiasis group than in the non-cholelithiasis group (63.08% vs. 37.16%, P < 0.001). Significant differences were found among various eosinophil count quartiles for C. sinensis infection, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), γ-glutamyltranspeptidase (γ-GT), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), creatinine (CRE), blood urea nitrogen (BUN), uric acid (UA) and non-alcoholic fatty liver disease (NAFLD) (all P < 0.001). A significant positive correlation was found between eosinophil count and log-transformed C. sinensis egg count (r = 0.9477, P < 0.001). Multiple logistic regression analysis revealed that light and moderate intensities of C. sinensis infection were associated with cholelithiasis (P < 0.01 and P < 0.001, respectively), and C. sinensis infection with eosinophil count ranging from 0.05 to 0.5 × 109/l were associated with cholelithiasis (P < 0.05). In conclusion, our findings suggest that the light and moderate infections of C. sinensis with eosinophil count ranging from 0.05 to 0.5 × 109/l may be associated with a higher risk of cholelithiasis.
Deep Low‐Frequency Earthquakes Associated With the Eruptions of Shinmoe‐dake in KirishimaVolcanoes
Authors: Kurihara Ryo , Obara Kazushige , Takeo Akiko , Tanaka Yusaku 
Published: November 2019

AbstractDeep low‐frequency (DLF) earthquakes occur beneath the Kirishima volcanoes in southwest Japan at depths of 10–30 km. In this study, we aim to reveal the relationship between DLF earthquakes and volcanic activity including eruptions by relocating the hypocenters of the earthquakes using the network correlation coefficient method and detecting the earthquakes comprehensively using the matched filter technique. Hypocenters of DLF earthquakes are found to be concentrated in some separated small clusters within depths of 10–15 and 20–27 km. Activation of deeper DLF earthquakes had been observed for approximately 2 years from December 2009, during which various styles of eruptions occurred. Such a 2‐year increase in DLF seismicity was well correlated with crustal deformation because of the volume change of a magma reservoir. The waveforms and hypocenters of DLF earthquakes during the activation period were different from those during other time periods. The activated DLF earthquakes mostly had low dominant frequencies and were located in four deeper clusters. The activation of each cluster was switched 3 times at the transition of the eruption styles. These results suggest that DLF earthquakes might occur near magma sills and could be triggered by fluid flow in the changing paths by complex eruption processes. In addition, the waveforms and hypocenters of DLF earthquakes associated with the 2018 eruptions are different from those associated with the 2011 eruptions. The fluid paths of the 2018 eruptions might be different from those of the 2011 eruptions.
Reversible magnetoelectric switching in multiferroic three-dimensional nanocup heterostructure films
Authors: An Hyunji , Hong Hyo Jin , Jo Yong-Ryun , Jung Soon-Gil , Kim Sangmo , Kim Sangwoo , Lee Jongmin , Choi Hojoong , Yoon Hongji , Kim So-Young , Song Jaesun , Jeong Sang Yun , Lee Byoung Hun , Koo Tae-Yeong , Park Tuson , Ko Kyung-Tae , Kim Bongjae , Kim Bong-Joong , Bark Chung Wung , Lee Sanghan 
Published: November 2019

AbstractSelf-assembled nanocomposite films containing ferroelectric and ferromagnetic phases have attracted enormous research interest because they are the most promising candidates for practical multiferroic applications. However, obtaining a genuine magnetoelectric (ME) coupling effect is still challenging in this research area. To substantially improve the ME effect, new heterostructure designs with efficient strain control between two phases are urgently needed. Herein, a novel three-dimensional (3D) nanocup architecture of a heterostructure film is developed. To establish the unique architecture, a heavily Co, Fe-doped ferroelectric Bi3.25La0.75Ti3O12(BLT) target was used during the growth of BLT thin films via pulsed laser deposition. Consequently, 3D nanocup-structured CoFe2O4(CFO) particles formed inside the BLT via spontaneous nucleation and agglomeration. The 3D nanocup BLT-CFO film exhibited magnetically controlled reversible dielectric switching, which is direct evidence of strong ME coupling caused by the efficient interfacial strain coupling and low leakage of the novel nanocup architecture. The obtained results strongly suggest that the 3D nanocup heterostructure film significantly improves the ME coupling effect. In addition, we propose a new paradigm in the architecture design of self-assembled nanocomposite films for diverse multifunctional devices.
Are Asian foods as “fattening” as western-styled fast foods?
Authors: Henry Christiani Jeyakumar , Kaur Bhupinder , Quek Rina Yu Chin 
Published: November 2019

AbstractIn Asia, the consumption of western-styled fast foods is widely perceived as the cause of the rise in obesity and chronic disease. Twenty-five of the most popular local Asian foods were compared for energy, total fat, saturated fat, sodium, and cholesterol with twenty-nine western-styled fast foods. The comparative analysis showed no significant difference in energy (p = 0.150) and total fat (p = 0.346) between the two food categories. These findings suggest that many local Asian foods contribute as much energy and total fat in a single meal as western-styled fast foods. Local Asian foods had greater amounts of sodium (p < 0.001), saturated fat (p = 0.007), and cholesterol (p = 0.009) than western-styled fast foods. The persistent presumption that the consumption of western-styled fast foods is the cause of obesity in Asia needs to be challenged. This observation that local Asian foods are as energy dense as western-styled fast foods, will enable us to redress the necessary strategies to address the Asian diet-health debate.
SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals
Authors: Andres-Alonso Maria , Ammar Mohamed Raafet , Butnaru Ioana , Gomes Guilherme M. , Acuña Sanhueza Gustavo , Raman Rajeev , Yuanxiang PingAn , Borgmeyer Maximilian , Lopez-Rojas Jeffrey , Raza Syed Ahsan , Brice Nicola , Hausrat Torben J. , Macharadze Tamar , Diaz-Gonzalez Silvia , Carlton Mark , Failla Antonio Virgilio , Stork Oliver , Schweizer Michaela , Gundelfinger Eckart D. , Kneussel Matthias , Spilker Christina , Karpova Anna , Kreutz Michael R. 
Published: November 2019

AbstractAmphisomes are organelles of the autophagy pathway that result from the fusion of autophagosomes with late endosomes. While biogenesis of autophagosomes and late endosomes occurs continuously at axon terminals, non-degradative roles of autophagy at boutons are barely described. Here, we show that in neurons BDNF/TrkB traffick in amphisomes that signal locally at presynaptic boutons during retrograde transport to the soma. This is orchestrated by the Rap GTPase-activating (RapGAP) protein SIPA1L2, which connects TrkB amphisomes to a dynein motor. The autophagosomal protein LC3 regulates RapGAP activity of SIPA1L2 and controls retrograde trafficking and local signaling of TrkB. Following induction of presynaptic plasticity, amphisomes dissociate from dynein at boutons enabling local signaling and promoting transmitter release. Accordingly,sipa1l2knockout mice show impaired BDNF-dependent presynaptic plasticity. Taken together, the data suggest that in hippocampal neurons, TrkB-signaling endosomes are in fact amphisomes that during retrograde transport have local signaling capacity in the context of presynaptic plasticity.
7-Deazaguanine modifications protect phage DNA from host restriction systems
Authors: Hutinet Geoffrey , Kot Witold , Cui Liang , Hillebrand Roman , Balamkundu Seetharamsingh , Gnanakalai Shanmugavel , Neelakandan Ramesh , Carstens Alexander B. , Fa Lui Chuan , Tremblay Denise , Jacobs-Sera Deborah , Sassanfar Mandana , Lee Yan-Jiun , Weigele Peter , Moineau Sylvain , Hatfull Graham F. , Dedon Peter C. , Hansen Lars H. , de Crécy-Lagard Valérie 
Published: November 2019

AbstractGenome modifications are central components of the continuous arms race between viruses and their hosts. The archaeosine base (G+), which was thought to be found only in archaeal tRNAs, was recently detected in genomic DNA of Enterobacteria phage 9g and was proposed to protect phage DNA from a wide variety of restriction enzymes. In this study, we identify three additional 2′-deoxy-7-deazaguanine modifications, which are all intermediates of the same pathway, in viruses: 2′-deoxy-7-amido-7-deazaguanine (dADG), 2′-deoxy-7-cyano-7-deazaguanine (dPreQ0) and 2′-deoxy-7- aminomethyl-7-deazaguanine (dPreQ1). We identify 180 phages or archaeal viruses that encode at least one of the enzymes of this pathway with an overrepresentation (60%) of viruses potentially infecting pathogenic microbial hosts. Genetic studies with the Escherichia phage CAjan show that DpdA is essential to insert the 7-deazaguanine base in phage genomic DNA and that 2′-deoxy-7-deazaguanine modifications protect phage DNA from host restriction enzymes.
Programmed DNA elimination of germline development genes in songbirds
Authors: Kinsella Cormac M. , Ruiz-Ruano Francisco J. , Dion-Côté Anne-Marie , Charles Alexander J. , Gossmann Toni I. , Cabrero Josefa , Kappei Dennis , Hemmings Nicola , Simons Mirre J. P. , Camacho Juan Pedro M. , Forstmeier Wolfgang , Suh Alexander 
Published: November 2019

AbstractIn some eukaryotes, germline and somatic genomes differ dramatically in their composition. Here we characterise a major germline–soma dissimilarity caused by a germline-restricted chromosome (GRC) in songbirds. We show that the zebra finch GRC contains >115 genes paralogous to single-copy genes on 18 autosomes and the Z chromosome, and is enriched in genes involved in female gonad development. Many genes are likely functional, evidenced by expression in testes and ovaries at the RNA and protein level. Using comparative genomics, we show that genes have been added to the GRC over millions of years of evolution, with embryonic development genes bicc1 and trim71 dating to the ancestor of songbirds and dozens of other genes added very recently. The somatic elimination of this evolutionarily dynamic chromosome in songbirds implies a unique mechanism to minimise genetic conflict between germline and soma, relevant to antagonistic pleiotropy, an evolutionary process underlying ageing and sexual traits.
Genomic and immune profiling of pre-invasive lung adenocarcinoma
Authors: Chen Haiquan , Carrot-Zhang Jian , Zhao Yue , Hu Haichuan , Freeman Samuel S. , Yu Su , Ha Gavin , Taylor Alison M. , Berger Ashton C. , Westlake Lindsay , Zheng Yuanting , Zhang Jiyang , Ramachandran Aruna , Zheng Qiang , Pan Yunjian , Zheng Difan , Zheng Shanbo , Cheng Chao , Kuang Muyu , Zhou Xiaoyan , Zhang Yang , Li Hang , Ye Ting , Ma Yuan , Gao Zhendong , Tao Xiaoting , Han Han , Shang Jun , Yu Ying , Bao Ding , Huang Yechao , Li Xiangnan , Zhang Yawei , Xiang Jiaqing , Sun Yihua , Li Yuan , Cherniack Andrew D. , Campbell Joshua D. , Shi Leming , Meyerson Matthew 
Published: November 2019

AbstractAdenocarcinoma in situ and minimally invasive adenocarcinoma are the pre-invasive forms of lung adenocarcinoma. The genomic and immune profiles of these lesions are poorly understood. Here we report exome and transcriptome sequencing of 98 lung adenocarcinoma precursor lesions and 99 invasive adenocarcinomas. We have identified EGFR, RBM10, BRAF, ERBB2, TP53, KRAS, MAP2K1 and MET as significantly mutated genes in the pre/minimally invasive group. Classes of genome alterations that increase in frequency during the progression to malignancy are revealed. These include mutations in TP53, arm-level copy number alterations, and HLA loss of heterozygosity. Immune infiltration is correlated with copy number alterations of chromosome arm 6p, suggesting a link between arm-level events and the tumor immune environment.
DNA origami cryptography for secure communication
Authors: Zhang Yinan , Wang Fei , Chao Jie , Xie Mo , Liu Huajie , Pan Muchen , Kopperger Enzo , Liu Xiaoguo , Li Qian , Shi Jiye , Wang Lihua , Hu Jun , Wang Lianhui , Simmel Friedrich C. , Fan Chunhai 
Published: November 2019

AbstractBiomolecular cryptography exploiting specific biomolecular interactions for data encryption represents a unique approach for information security. However, constructing protocols based on biomolecular reactions to guarantee confidentiality, integrity and availability (CIA) of information remains a challenge. Here we develop DNA origami cryptography (DOC) that exploits folding of a M13 viral scaffold into nanometer-scale self-assembled braille-like patterns for secure communication, which can create a key with a size of over 700 bits. The intrinsic nanoscale addressability of DNA origami additionally allows for protein binding-based steganography, which further protects message confidentiality in DOC. The integrity of a transmitted message can be ensured by establishing specific linkages between several DNA origamis carrying parts of the message. The versatility of DOC is further demonstrated by transmitting various data formats including text, musical notes and images, supporting its great potential for meeting the rapidly increasing CIA demands of next-generation cryptography.
Response to Olaparib in a Patient with Germline BRCA2 Mutation and Breast Cancer Leptomeningeal Carcinomatosis
Authors: Exman Pedro , Mallery Robert M. , Lin Nancy U. , Parsons Heather A. 
Published: November 2019

AbstractLeptomeningeal carcinomatosis (LC) is a devastating complication of metastatic cancer that disproportionately affects patients with advanced breast cancer. Moreover, those with BRCA1/2-mutated disease more often experience leptomeningeal metastasis. Treatment options for LC are limited and often include significant toxicities. PARP inhibitors offer an important potential treatment for patients with BRCA1/2-mutated breast and ovarian cancers, but clinical studies excluded patients with central nervous system (CNS) metastases, including LC. Efficacy data in this area are therefore limited, although a phase I study of olaparib in glioblastoma did show CNS penetration. Here we report a case of a patient with BRCA2-mutated breast cancer and solitary recurrence in the leptomeninges with ongoing complete response to treatment with the PARP inhibitor olaparib. PARP inhibitors may be an important treatment option for patients with BRCA-mutated disease and LC, and warrant further study.
Low-intensity educational interventions supporting self-management to improve outcomes related to chronic breathlessness: a systematic review
Authors: Raymond Bronwyn , Luckett Tim , Johnson Miriam , Hutchinson Ann , Lovell Melanie , Phillips Jane 
Published: November 2019

AbstractChronic breathlessness is debilitating and frightening, often resulting in emergency department presentations with acute-on-chronic breathlessness. Self-management is complex, involving 14 components as identified by the Practical Systematic Review in Self-Management Support (PRISMS). Low-intensity educational interventions that support breathlessness self-management through written/visual educational materials, alongside limited health professional support, are available. Our aim was to describe components of low-intensity educational interventions that support and improve self-management for adults with chronic breathlessness and evaluate their efficacy for improving breathlessness-related outcomes. A systematic review was conducted, including RCTs that compared these interventions with usual care in adults with chronic disease. Synthesis took a narrative approach utilizing the PRISMS taxonomy and Template for Intervention Description and Replication (TIDieR) checklist. Of the 1948 articles identified, 7 met criteria reporting 7 RCTs using 6 interventions. Studies utilized 12 out of 14 PRISMS components, the most frequent being training/rehearsal for psychological strategies. Evidence for effectiveness was inconsistent and attempts to identify beneficial components were confounded by intervention complexity and heterogeneity. The optimal content and delivery of low-intensity educational interventions that support self-management to improve chronic breathlessness-related outcomes in adults cannot be defined from current published literature. Future research should incorporate more detailed, standardized reporting to enable comparison and meta-analysis.
Coherent transfer of quantum information in a silicon double quantum dot using resonant SWAP gates
Authors: Sigillito A. J. , Gullans M. J. , Edge L. F. , Borselli M. , Petta J. R. 
Published: November 2019

AbstractSpin-based quantum processors in silicon quantum dots offer high-fidelity single and two-qubit operation. Recently multi-qubit devices have been realized; however, many-qubit demonstrations remain elusive, partly due to the limited qubit-to-qubit connectivity. These problems can be overcome by using SWAP gates, which are challenging to implement in devices having large magnetic field gradients. Here we use a primitive SWAP gate to transfer spin eigenstates in 100 ns with a fidelity of $${\bar{F}}_{{\rm{SWAP}}}^{{\rm{(p)}}}=98 \%$$F¯SWAP(p)=98%. By swapping eigenstates we are able to demonstrate a technique for reading out and initializing the state of a double quantum dot without shuttling charges through the quantum dot. We then show that the SWAP gate can transfer arbitrary two-qubit product states in 300 ns with a fidelity of $${\bar{F}}_{{\rm{SWAP}}}^{{\rm{(c)}}}=84 \%$$F¯SWAP(c)=84%. This work sets the stage for many-qubit experiments in silicon quantum dots.
From Point to Filament Defects in Hybrid Nematic Films
Authors: Chiccoli Cesare , Pasini Paolo , Zannoni Claudio , Skačej Gregor , Yoshida Hiroyuki , Hiroshima Taiga , Sunami Kanta , Ouchi Tomohiro , Ozaki Masanori 
Published: November 2019

AbstractWe have studied nematic hybrid films with homeotropic alignment at the top surface and various controlled degrees of in plane ordering, going from a random degenerate organization to a completely uniform alignment along one direction, at the bottom one. We show, by Monte Carlo (MC) computer simulations and experiments on photopatterned films with the bottom support surface fabricated with in-plane order similar to the simulated ones, that the point defects observed in the case of random planar orientations at the bottom tend to arrange along a filament as the surface ordering is sufficiently increased. MC simulations complement the polarized microscopy texture observations allowing to inspect the 3D structure of the defects and examine the role of elastic constants.
Time-domain Formulation of a Multi-layer Plane Circuit Coupled with Lumped-parameter Circuits using Maxwell Equations
Authors: Jinno Souma , Kitora Shuji , Toki Hiroshi , Abe Masayuki 
Published: November 2019

AbstractWe calculate electromagnetic phenomena in the multi-layer plane circuit starting from the Maxwell equations. We present a numerical method of potential and current density in two-dimensional conductors, where their time developments are treated as phenomena of wave propagation. We treat the plane conductors by dividing them into small finite-volume elements, similar to the case of the partial element equivalent circuit method, and the transport equations are then solved by the finite-difference time-domain method. Furthermore, we develop a calculation method for the boundary in a multi-layer plane by applying the method we have used in multi-transmission lines. We formulate the boundary conditions of a multi-layer plane coupled with lumped-parameter circuits and introduce an algorithm to reduce calculation costs that are largely associated with the two-dimensional extension from the multi-transmission-line case. We perform calculations of the wave propagation of potential, current density, and charge density in the time domain for a simple plane circuit. These calculations are presented as supplementary materials of the present paper.
Quantum Neimark-Sacker bifurcation
Authors: Yusipov I. I. , Ivanchenko M. V. 
Published: November 2019

AbstractRecently, it has been demonstrated that asymptotic states of open quantum system can undergo qualitative changes resembling pitchfork, saddle-node, and period doubling classical bifurcations. Here, making use of the periodically modulated open quantum dimer model, we report and investigate a quantum Neimark-Sacker bifurcation. Its classical counterpart is the birth of a torus (an invariant curve in the Poincaré section) due to instability of a limit cycle (fixed point of the Poincaré map). The quantum system exhibits a transition from unimodal to bagel shaped stroboscopic distributions, as for Husimi representation, as for observables. The spectral properties of Floquet map experience changes reminiscent of the classical case, a pair of complex conjugated eigenvalues approaching a unit circle. Quantum Monte-Carlo wave function unraveling of the Lindblad master equation yields dynamics of single trajectories on “quantumtorus” and allows for quantifying it by rotation number. The bifurcation is sensitive to the number of quantum particles that can also be regarded as a control parameter.
Innovative particle standards and long-lived imaging for 2D and 3D dSTORM
Authors: Provost Angelina , Rousset Corentin , Bourdon Laura , Mezhoud Sarra , Reungoat Emma , Fourneaux Camille , Bresson Timothée , Pauly Marine , Béard Nicolas , Possi-Tchouanlong Laura , Grigorov Boyan , Bouvet Philippe , Diaz Jean-Jacques , Chamot Christophe , Pécheur Eve-Isabelle , Ladavière Catherine , Charreyre Marie-Thérèse , Favier Arnaud , Place Christophe , Monier Karine 
Published: November 2019

AbstractDirect stochastic optical reconstruction microscopy (dSTORM), developed in the last decade, has revolutionised optical microscopy by enabling scientists to visualise objects beyond the resolution provided by conventional microscopy (200 nm). We developed an innovative method based on blinking particle standards and conditions for long-lived imaging over several weeks. Stable localisation precisions within the 10 nm-range were achieved for single virions and in cellulo 2D imaging of centrosomes, as well as their reliable reconstruction in 3D dSTORM.