bluuebunny/crossref_metadata_2025_split huggingface dataset:
A randomised controlled feasibility study of interpersonal art psychotherapy for the treatment of aggression in people with intellectual disabilities in secure care
Authors: Hackett Simon S. , Zubala Ania , Aafjes-van Doorn Katie , Chadwick Thomas , Harrison Toni Leigh , Bourne Jane , Freeston Mark , Jahoda Andrew , Taylor John L. , Ariti Cono , McNamara Rachel , Pennington Lindsay , McColl Elaine , Kaner Eileen 
Published: November 2020

AbstractBackgroundRates of aggression in inpatient secure care are higher than in other psychiatric inpatient settings. People with intellectual disabilities in secure care require adapted psychological treatments. Interpersonal art psychotherapy incorporates the use of creative art making approaches by participants, thus reducing sole reliance upon verbal interactions during psychotherapy for people who may have communication difficulties. During interpersonal art psychotherapy, participants are individually supported by their therapist to consider how they conduct relationships. This includes the influence and impact of interpersonal issues resulting in repeated patterns of conflict. The key feasibility objectives were to assess recruitment and retention rates, follow-up rates and trial procedures such as randomisation, allocation and identifying any practical or ethical problems. In addition, a preliminary ‘signal’ for the intervention was considered and an indicative sample size calculation completed. The acceptability of a potential third trial arm attentional control condition, mindful colouring-in, was assessed using four single-case design studies and a UK trial capacity survey was conducted.MethodsAdult patients with intellectual disabilities in secure care were recruited and randomised to either interpersonal art psychotherapy or delayed treatment in this multi-site study. Outcomes were assessed using weekly observations via the Modified Overt Aggression Scale and a range of self-report measures. Within study reporting processes, qualitative interviews and a survey were completed to inform trial feasibility.ResultsRecruitment procedures were successful. The target of recruiting 20 participants to the trial from multiple sites was achieved within 8 months of the study opening. All participants recruited to the treatment arm completed interpersonal art psychotherapy. Between-group differences of interpersonal art psychotherapy versus the delayed treatment control showed a ‘signal’ effect-size of .65 for total scores and .93 in the verbal aggression sub-scale. There were no amendments to the published protocol. The assessment of key feasibility objectives were met and the trial procedures were acceptable to all involved in the research.ConclusionThis study suggested that a randomised controlled trial of interpersonal art psychotherapy is acceptable and feasible.Trial registrationISRCTN14326119(Retrospectively Registered).
De-implementation of detrimental feeding practices: a pilot protocol
Authors: Swindle Taren , Rutledge Julie M. , Johnson Susan L. , Selig James P. , Curran Geoff M. 
Published: November 2020

AbstractBackgroundEarly childhood educators (ECEs) often use detrimental feeding practices and are slow to implement positive feeding practices. Nevertheless, few studies have aimed to understand and change ECEs’ feeding practices. This gap needs to be addressed because implementation (i.e., adding new, evidence-based practices) and de-implementation (i.e., stopping low-value or harmful practices) are distinct processes that require unique strategies.MethodsWe will develop a de-implementation strategy for detrimental feeding practices using evidence-based quality improvement (EBQI) sessions to engage stakeholders and draw on the Niven process model for de-implementation. Then, we will investigate the effects of the de-implementation strategy in a proof-of-principle study. The de-implementation strategy will be evaluated in 2 partnering childcare agencies using a pre-post, within-site design. For our primary outcome, we will interview educators throughout the school year to assess the feasibility and acceptability of the intervention and survey them with standard measures for assessing feasibility and acceptability. For secondary outcomes, we will investigate its effects on the use of detrimental and evidence-based feeding practices by teachers and impacts on child BMI and diet.DiscussionThe current study will establish the feasibility and acceptability of our de-implementation approach and will provide preliminary data toward 3 predicted secondary outcomes: (1) decreased detrimental feeding practices by ECEs, (2) increased adoption of and fidelity to nutrition promotion practices, and (3) improved child dietary outcomes. These results are expected to contribute to the uptake and sustainability of mealtime interventions to improve the diets of young children. Results will also apply to the field of implementation science by informing processes for developing de-implementation approaches in a community setting.
New insights into the morphology and evolution of the ventral pharynx and jaws in Histriobdellidae (Eunicida, Annelida)
Authors: Tzetlin Alexander , Budaeva Nataliya , Vortsepneva Elena , Helm Conrad 
Published: November 2020

AbstractThe jaw apparatus in several annelid families represents a powerful tool for systematic approaches and evolutionary investigations. Nevertheless, for several taxa, this character complex has scarcely been investigated, and complete comparative analyses of all annelid jaws are lacking. In our comprehensive study, we described the fine structure of the jaw apparatus and the ventral pharyngeal organ (VPO) in Histriobdella homari – a minute ectocommensal of lobsters putatively belonging to the Eunicida – using different comparative morphological approaches, including SEM, TEM, CLSM and subsequent 3D reconstruction. The H. homari jaw apparatus is composed of ventral paired mandibles and dorsal symmetrical maxillae consisting of numerous dental plates, ventral carriers and an unpaired dorsal rod, and the general assemblage and arrangement of the different parts are highly comparable to those of other eunicid families. The jaw ultrastructure of histriobdellids resembles that of the families Dorvilleidae and (juvenile) Onuphidae. Furthermore, our data reveal that in the process of development of the jaw apparatus, the mandibles, maxillae II and unpaired dorsal rod are formed first, and the remaining maxillae and ventral carriers appear later. Notably, the muscular apparatus differs from that in Dorvilleidae and Onuphidae in terms of the number and arrangement of muscle fibers encompassing the jaws – not only because of the very small size of Histriobdella but also because histriobdellid maxillary protraction occurs due to straightening of the dorsal rod and thus requires a different muscular scaffold. Based on our investigations, the arrangement of the muscular apparatus of the jaws, the presence of paired ventral carriers and the dorsal rod, and the morphology of the ventral pharyngeal organ represent a histriobdellid autapomorphy. Our datasets form a basis for further comparative analyses to elucidate the evolution of Eunicida and jaw-bearing Annelida.
Recommendations from a James Lind Alliance priority setting partnership - a qualitative interview study
Authors: Jongsma Karin , van Seventer Juliette , Verwoerd Anouk , van Rensen Annemiek 
Published: November 2020

AbstractBackgroundThe James Lind Alliance (JLA) offers a method for research priority setting with patients, clinicians and carers. The method is increasingly used but publications primarily discuss the outcome of such projects, rather than reflecting on the JLA method itself. Scrutiny of the method is crucial in order to understand and correctly interpret its outcomes.MethodsWe conducted a qualitative interview study with people involved in a JLA project into Juvenile Idiopathic Arthritis (JIA) (n = 30) to better understand the mechanisms, procedures and decisional processes during such a project and to formulate recommendations for those who consider starting a JLA project in the future.ResultsFour main themes were identified: 1) motivations, goals and expectations 2) inclusivity, roles and representation 3) procedures and decision-making 4) outcomes and future steps.ConclusionWhile the top 10 of ‘evidence uncertainties’ seems to take the centre stage in JLA projects, the ways in which these priorities are determined may be influenced by ‘process uncertainties’. We have formulated ten specific recommendations for future JLA projects. Reflection on and reporting of these process uncertainties would contribute to the improvement of JLA projects and increase the validity of the outcome of such projects.
Intercultural pedagogies: experiencing the kungfu teaching methods at the Shaolin Temple
Authors: Nešković Marta 
Published: November 2020

AbstractThe Shaolin Temple is a unique religious institution in China. It is the most renowned temple of Chan Buddhism and, at the same time, a famed site of intensive cultivation of traditional kungfu. Besides running the kungfu program for selected Chinese youth, the Temple offers a program for foreign students interested in training kungfu in its authentic cultural setting. Founded on anthropology of education, the theories of embodiment, and the theory of practice, our research project is focused on the relationship between the Shaolin kungfu and Chan Buddhism. The aim of this paper is to describe the students’ perceptions of the Shaolin kungfu teaching methods through the analyses of their narrated personal experiences. The research is based on our 16 months of fieldwork in the Temple, which comprised a full participation in the training program as well as the formal and informal interviews and the group discussions with the students. The paper presents the students’ perceptions of the Shaolin masters’ training methods, the main kungfu principles and their sources, as well as the differences between the training approaches in the Temple and in their home countries. In addition, the study brings forth the concept of intercultural martial arts pedagogies and its application in a representative Chan Buddhist setting.
Phytochemical constituents and antibacterial activity of Citrus lemon leaves
Authors: Asker Mohsen , El-gengaihi Souad E. , Hassan Emad M. , Mohammed Mona A. , Abdelhamid Sayeda A. 
Published: November 2020

AbstractBackgroundThe study investigated the phytochemical constituents and antibacterial activity ofCitrus lemonvolatile oil extracted from pruning leaves collected from a private farm at Nobariya district against Gram-positive "Staphylococcus aureusNRRL B-313 andBacillus cereusNRC" and Gram-negative "Pseudomonas aeruginosaNRC B-32 andEscherichia coliNRC B-3703".ResultsThe oil obtained from powdered driedC. lemonleaves was analyzed by GC–MS to identify their constituents. The analysis revealed the presence of sabinene, carene, limonene, and β-ocimene. The leaves volatile oil showed a remarkable inhibition againstS. aureus(32 ± 0.01 mm) andP. aeruginosa(49 ± 0.01 mm) and it had a strong effect on the DNA, RNA, lipids, and protein biosynthesis in cells ofS. aureusand had a strong effect on the lipids biosynthesis in cells ofP. aeruginosa.ConclusionThe results in this study suggested thatC. lemonleaves could be beneficial in developing a novel antibiotic and studied its mode of action on the pathogenic microorganism’s cells.
Comparison of stroke care parameters in acute ischemic stroke patients with and without concurrent Covid-19. A Nationwide analysis
Authors: Richter Daniel , Krogias Christos , Eyding Jens , Bartig Dirk , Grau Armin , Weber Ralph 
Published: November 2020

Abstract
Background
Comparing health care parameters of acute ischemic stroke (AIS) patients with and without concurrent coronavirus disease 2019 (Covid-19, SARS-CoV-2 infection), may be helpful in terms of optimizing clinical and public health care during pandemic.

Methods
We evaluated a nationwide administrative database of all hospitalized patients with main diagnosis of acute ischemic stroke with/without diagnosis of Covid-19 who were hospitalized during the time period from January 16th to May 15th, 2020. Data from a total of 1463 hospitals in Germany were included. We compared case numbers, treatment characteristics (intravenous thrombolysis, IVT; mechanical thrombectomy, MT; treated on an intensive care unit, stroke unit or regular ward) and in-hospital mortality of AIS with and without concurrent diagnosis of Covid-19.

Results
From a total of 30,864 hospitalized Covid-19 patients during the evaluation period in Germany, we identified a subgroup of 213 patients with primary diagnosis of AIS. Compared to the 68,700 AIS patients without Covid-19, this subgroup showed a similar rate of IVT (16.4% vs. 16.5%, p = 0.985) but a significantly lower rate of MT (3.8% vs. 7.9%, p = 0.017). In-hospital mortality rate was significantly higher in patients with AIS and concurrent Covid-19 compared to non-infected AIS patients (22.5% vs. 7.8%, p < 0.001).

Conclusion
These nationwide data point out differences in mortality and medical treatment regime between AIS patients with and without concurrent Covid-19. Since the pandemic is still ongoing, these data draw attention to AIS as a less frequent but often fatal comorbidity in Covid-19 patients.
Imetelstat Achieves Meaningful and Durable Transfusion Independence in High Transfusion–Burden Patients With Lower-Risk Myelodysplastic Syndromes in a Phase II Study
Authors: Steensma David P. , Fenaux Pierre , Van Eygen Koen , Raza Azra , Santini Valeria , Germing Ulrich , Font Patricia , Diez-Campelo Maria , Thepot Sylvain , Vellenga Edo , Patnaik Mrinal M. , Jang Jun Ho , Varsos Helen , Bussolari Jacqueline , Rose Esther , Sherman Laurie , Sun Libo , Wan Ying , Dougherty Souria , Huang Fei , Feller Faye , Rizo Aleksandra , Platzbecker Uwe 
Published: November 2020

PURPOSE Patients with lower-risk (LR) myelodysplastic syndromes (MDS) who are RBC transfusion dependent and have experienced relapse after or are refractory to erythropoiesis-stimulating agent (ESA) have limited treatment options. High telomerase activity and human telomerase reverse-transcription expression in clonal hematopoietic cells have been reported in patients with MDS. Imetelstat, a first-in-class competitive inhibitor of telomerase enzymatic activity, targets cells with active telomerase. We report efficacy, safety, and biomarker data for patients with LR MDS who are RBC transfusion dependent and who were relapsed/refractory to ESAs. PATIENTS AND METHODS In this two-part phase II/III study (MDS3001), the primary end point was 8-week RBC transfusion independence (TI) rate, with key secondary end points of 24-week RBC TI rate, TI duration, and hematologic improvement-erythroid. RESULTS Data from the phase II part of the study are reported. Of 57 patients enrolled and treated (overall population), 38 were non-del(5q) and hypomethylating agent and lenalidomide naïve (subset population). The 8- and 24-week RBC TI rates in the overall population were 37% and 23%, respectively, with a median TI duration of 65 weeks. In the subset population, 8- and 24-week RBC TI rates were 42% and 29%, respectively, with a median TI duration of 86 weeks. Eight-week TI rate was observed across all subgroups evaluated. Cytogenetic and mutational data revealed a reduction of the malignant clones, suggesting disease modification activity. The most common adverse events were cytopenias, typically reversible within 4 weeks. CONCLUSION Imetelstat treatment results in a meaningful, durable TI rate across a broad range of heavily transfused patients with LR MDS who are ineligible for or relapsed/refractory to ESAs. Biomarker analyses indicated effects on the mutant malignant clone.
The Curious Case of the Octagonal Temple
Authors: Buckee Fiona 
Published: November 2020

Abstract
The Muṇḍeśvarī temple near Bhabuā in southwest Bihar is an octagonal, sandstone monument without a spire. Scholars have dated the temple to the first half of the seventh century, primarily on account of early inscriptions from the site and the style of the door frames. Few monuments survive from this nascent stage of structural North Indian temple architecture, and the Muṇḍeśvarī temple is intriguing because it is an anomaly in terms of its size, composition, and the shape of its plan.
This study argues that the Muṇḍeśvarī temple has been misdated, and presents a systematic architectural analysis that highlights multiple features and irregularities that are incompatible with early North Indian design. The paper proposes that, rather than being seventh century, the octagonal shrine was built about a millennia later, in the sixteenth–seventeenth century, incorporating doorways and moldings salvaged from the ruins of the seventh century temples that once graced the hilltop. The latter part of the article considers how the Muṇḍeśvarī temple came to be buried by the end of the eighteenth century, and questions whether the Archaeological Survey of India might have altered the temple's appearance during the reconstructive work they undertook at the start of the twentieth century.
Image, Body, and Simulation of the Afterlife in the Early Medieval Sarcophagus of Prince Yuan Mi
Authors: Shi Jie 
Published: November 2020

Abstract
Dated to 524 ce, the lavishly carved stone sarcophagus of the Northern Wei Prince Yuan Mi exemplifies an early Chinese method using a diagonal gaze as a visual device to construct a three-dimensional space. On the exterior faces of the sarcophagus, the anonymous artist simulated a three-layered space, imagining the deceased's wooden coffin (the inner layer) contained in his burial chamber (middle layer), which in turn is embraced by a complex three-dimensional natural and supernatural world (the outer layer). In the middle layer, eight figures cast a slant gaze from behind four windows at filial paragons dwelling in the outer layer. This gaze was used as a rhetorical device to bridge the physical and psychological gap between the gazers and those upon whom they gaze. Evoking the idiom found in medieval Chinese texts of “watching the ancients as neighbors,” the artist defined the deceased as a neighbor of the ancient filial paragons who dwell in an ideal landscape as recluses. In addition to the visual analysis of the sarcophagus, this article also examines the epitaph buried along with the sarcophagus. While the carving praises the private virtue of the dead, the text paints another rosy picture of the deceased prince as a good official. Eventually, the image and text were used in tandem to create a perfect image of the deceased.
Characterisation of baseline microbiological and host factors in an inception cohort of people with surgical wounds healing by secondary intention reveals circulating IL-6 levels as a potential predictive biomarker of healing
Authors: Buckley Hannah , Dumville Jo , Hodgkinson Michael , Wearmouth Debbie , Barlow Gavin , van der Woude Marjan , Cullum Nicky , Chetter Ian , Lagos Dimitris 
Published: November 2020

Background: More than 2 million people per year are treated for surgical wounds in the UK. Over a quarter of these wounds are estimated to heal by secondary intention (from the “bottom up”) resulting in further complications and requiring increased healthcare resources. Identification of microbiological or host biomarkers that can predict healing outcomes may help to optimize the management of surgical wounds healing by secondary intention. However, the microbial and host factor heterogeneity amongst this diverse population is completely unexplored. Methods: We demonstrate feasibility of determining presence and levels of wound microbes and systemic host factors in an inception cohort of 54 people presenting with surgical wounds healing by secondary intention, who were subsequently followed-up for a period of 12-21 months. We present descriptive statistics for plasma levels of inflammatory, angiogenic cytokines and microRNAs, and we identify a range of wound colonizing microbes. We tentatively explore association with healing aiming to generate hypotheses for future research. Results: We report a potential correlation between poor healing outcomes and elevated interleukin (IL)-6 plasma levels at presentation (ρ=0.13) which requires confirmation. Conclusions: This study demonstrates the degree of biological heterogeneity amongst people with surgical wounds healing by secondary intention and proves the feasibility of embedding a biomarker discovery study in a cohort study in surgical wounds. Our results are essential for designing large biomarker discovery studies to further investigate the potential validity of circulating IL-6 or other factors as novel predictive biomarkers of healing for surgical wounds healing by secondary intention.
The Prevention of Tooth Wear
Authors: Mehta Shamir B , Banerji Subir 
Published: November 2020

With adult dentitions being retained for longer, issues relating to the wear of teeth are increasingly becoming of relevance to the general dental practitioner. As with any treatment plan, prevention is a fundamental and an important stage in the management of tooth wear. This article outlines the contemporary preventive features that the general dental practitioner should be aware of when dealing with patients presenting with tooth wear or exhibiting a susceptibility to this. CPD/Clinical Relevance: An understanding of the factors relevant to the prevention of tooth wear will enable an effective preventive regimen to be prescribed. This will play an integral role in the management of tooth wear and its sequalae.
Minimally Invasive Selective Caries Removal put into Practice
Authors: Dawett Bhupinder , Young Sarah , Deery Chris , Banerjee Avijit 
Published: November 2020

Dental caries remains a significant health problem globally, causing morbidity in those affected and consuming health resources. The management of caries consumes considerable finances both for individuals and the public purse. The scientific understanding of the dental caries process has evolved considerably over the last four decades with a move towards a minimum intervention oral care (MIOC) approach to managing patients. The minimally invasive operative intervention that retains demineralised, caries-affected dentine under a well-sealed restoration in order to avoid instrumentation close to the pulp, has shown clinical efficacy in treating individual teeth, as part of the MIOC framework. However, implementation of the selective caries removal approach in deep lesions is still not thought to be practised routinely by clinicians both globally, and in the UK. This article discusses some of the issues that may account for this and describes a case study using this operative strategy. CPD/Clinical Relevance: Restoring deep carious lesions can be a challenge, but using selective caries removal approaches will help minimise the adverse effects of pulp trauma.