bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rare-earth (Gd3+,Yb3+/Tm3+, Eu3+) co-doped hydroxyapatite as magnetic, up-conversion and down-conversion materials for multimodal imaging
Authors: Ignjatović Nenad L. , Mančić Lidija , Vuković Marina , Stojanović Zoran , Nikolić Marko G. , Škapin Srečo , Jovanović Sonja , Veselinović Ljiljana , Uskoković Vuk , Lazić Snežana , Marković Smilja , Lazarević Miloš M. , Uskoković Dragan P. 
Published: November 2019

AbstractTaking advantage of the flexibility of the apatite structure, nano- and micro-particles of hydroxyapatite (HAp) were doped with different combinations of rare earth ions (RE3+ = Gd, Eu, Yb, Tm) to achieve a synergy among their magnetic and optical properties and to enable their application in preventive medicine, particularly diagnostics based on multimodal imaging. All powders were synthesized through hydrothermal processing at T ≤ 200 °C. An X-ray powder diffraction analysis showed that all powders crystallized in P63/m space group of the hexagonal crystal structure. The refined unit-cell parameters reflected a decrease in the unit cell volume as a result of the partial substitution of Ca2+ with smaller RE3+ ions at both cation positions. The FTIR analysis additionally suggested that a synergy may exist solely in the triply doped system, where the lattice symmetry and vibration modes become more coherent than in the singly or doubly doped systems. HAp:RE3+ optical characterization revealed a change in the energy band gap and the appearance of a weak blue luminescence (λex = 370 nm) due to an increased concentration of defects. The “up”- and the “down”-conversion spectra of HAp:Gd/Yb/Tm and HAp:Gd/Eu powders showed characteristic transitions of Tm3+ and Eu3+, respectively. Furthermore, in contrast to diamagnetic HAp, all HAp:RE3+ powders exhibited paramagnetic behavior. Cell viability tests of HAp:Gd/Yb/Tm and HAp:Gd/Eu powders in human dental pulp stem cell cultures indicated their good biocompatibility.
Impact of Affective Multimedia Content on the Electroencephalogram and Facial Expressions
Authors: Siddharth Siddharth , Jung Tzyy-Ping , Sejnowski Terrence J. 
Published: November 2019

AbstractMost of the research in the field of affective computing has focused on detecting and classifying human emotions through electroencephalogram (EEG) or facial expressions. Designing multimedia content to evoke certain emotions has been largely motivated by manual rating provided by users. Here we present insights from the correlation of affective features between three modalities namely, affective multimedia content, EEG, and facial expressions. Interestingly, low-level Audio-visual features such as contrast and homogeneity of the video and tone of the audio in the movie clips are most correlated with changes in facial expressions and EEG. We also detect the regions associated with the human face and the brain (in addition to the EEG frequency bands) that are most representative of affective responses. The computational modeling between the three modalities showed a high correlation between features from these regions and user-reported affective labels. Finally, the correlation between different layers of convolutional neural networks with EEG and Face images as input provides insights into human affection. Together, these findings will assist in (1) designing more effective multimedia contents to engage or influence the viewers, (2) understanding the brain/body bio-markers of affection, and (3) developing newer brain-computer interfaces as well as facial-expression-based algorithms to read emotional responses of the viewers.
Efficiency score from data envelopment analysis can predict the future onset of hypertension and dyslipidemia: A cohort study
Authors: Nakamura Sho , Narimatsu Hiroto , Nakata Yoshinori , Sakaguchi Masahiko , Konta Tsuneo , Watanabe Masafumi , Ueno Yoshiyuki , Ishizawa Kenichi , Yamashita Hidetoshi , Kayama Takamasa , Yoshioka Takashi 
Published: November 2019

AbstractPrimary prevention focuses on ensuring that healthy people remain healthy. As it is practically difficult to provide intervention for an entire healthy population, it is essential to identify and target the at risk of risks population. We aimed to distinguish at risk of risks population using data envelopment analysis (DEA). Efficiency score was calculated from the DEA using a cohort sample and its association with the onset of hypertension and dyslipidemia was analyzed. A stratification analysis was performed according to the number of conventional risk factors in participants. The adjusted odds ratios (aORs) of the incidence of hypertension and dyslipidemia according to a 0.1-point increase in efficiency score were 0.66 (90% confidence interval [CI] 0.55–0.78, p < 0.0001) and 0.84 (90% CI 0.75–0.94, p = 0.01), respectively. In the stratification analysis, aOR of the incidence of hypertension according to a 0.1-point increase in efficiency score was 0.57 (90% CI 0.37–0.89, p = 0.04) in participants with no conventional risk factors. Participants with lower efficiency score were suggested to be at high risk for future onset of hypertension and dyslipidemia. The DEA might enable us to identify the risk of hypertension where conventional methods might fail.
Lipidomic analysis reveals sphingomyelin and phosphatidylcholine species associated with renal impairment and all-cause mortality in type 1 diabetes
Authors: Tofte Nete , Suvitaival Tommi , Ahonen Linda , Winther Signe A. , Theilade Simone , Frimodt-Møller Marie , Ahluwalia Tarunveer S. , Rossing Peter 
Published: November 2019

AbstractThere is an urgent need for a better molecular understanding of the pathophysiology underlying development and progression of diabetic nephropathy. The aim of the current study was to identify novel associations between serum lipidomics and diabetic nephropathy. Non-targeted serum lipidomic analyses were performed with mass spectrometry in 669 individuals with type 1 diabetes. Cross-sectional associations of lipid species with estimated glomerular filtration rate (eGFR) and urinary albumin excretion were assessed. Moreover, associations with register-based longitudinal follow-up for progression to a combined renal endpoint including ≥30% decline in eGFR, ESRD and all-cause mortality were evaluated. Median follow-up time was 5.0–6.4 years. Adjustments included traditional risk factors and multiple testing correction. In total, 106 lipid species were identified. Primarily, alkyl-acyl phosphatidylcholines, triglycerides and sphingomyelins demonstrated cross-sectional associations with eGFR and macroalbuminuria. In longitudinal analyses, thirteen lipid species were associated with the slope of eGFR or albuminuria. Of these lipids, phosphatidylcholine and sphingomyelin species, PC(O-34:2), PC(O-34:3), SM(d18:1/24:0), SM(d40:1) and SM(d41:1), were associated with lower risk of the combined renal endpoint. PC(O-34:3), SM(d40:1) and SM(d41:1) were associated with lower risk of all-cause mortality while an SM(d18:1/24:0) was associated with lower risk of albuminuria group progression. We report distinct associations between lipid species and risk of renal outcomes in type 1 diabetes, independent of traditional markers of kidney function.
Impact of stress-induced hyperglycemia on the outcome of children with trauma: A cross-sectional analysis based on propensity score-matched population
Authors: Tsai Yi-Wen , Wu Shao-Chun , Huang Chun-Ying , Hsu Shiun-Yuan , Liu Hang-Tsung , Hsieh Ching-Hua 
Published: November 2019

AbstractThis was a retrospective study of pediatric trauma patients and were hospitalized in a level-1 trauma center from January 1, 2009 to December 31, 2016. Stress-induced hyperglycemia (SIH) was defined as a hyperglycemia level ≥200 mg/dL upon arrival at the emergency department without any history of diabetes or a hemoglobin A1c level ≥6.5% upon arrival or during the first month of admission. The results demonstrated that the patients with SIH (n = 36) had a significantly longer length of stay (LOS) in hospital (16.4 vs. 7.8 days, p = 0.002), higher rates of intensive care unit (ICU) admission (55.6% vs. 20.9%, p < 0.001), and higher in-hospital mortality rates (5.6% vs. 0.6%, p = 0.028) compared with those with non-diabetic normoglycemia (NDN). However, in the 24-pair well-balanced propensity score-matched patient populations, in which significant difference in sex, age, and injury severity score were eliminated, patient outcomes in terms of LOS in hospital, rate of ICU admission, and in-hospital mortality rate were not significantly different between the patients with SIH and NDN. The different baseline characteristics of the patients, particularly injury severity, may be associated with poorer outcomes in pediatric trauma patients with SIH compared with those with NDN. This study also indicated that, upon major trauma, the response of pediatric patients with SIH is different from that of adult patients.
GPS mobility as a digital biomarker of negative symptoms in schizophrenia: a case control study
Authors: Depp Colin A. , Bashem Jesse , Moore Raeanne C. , Holden Jason L. , Mikhael Tanya , Swendsen Joel , Harvey Philip D. , Granholm Eric L. 
Published: November 2019

AbstractMobility is an important correlate of physical, cognitive, and mental health in chronic illness, and can be measured passively with mobile phone global positional satellite (GPS) sensors. To date, GPS data have been reported in a few studies of schizophrenia, yet it is unclear whether these data correlate with concurrent momentary reports of location, vary by people with schizophrenia and healthy comparison subjects, or associate with symptom clusters in schizophrenia. A total of 142 participants with schizophrenia (n = 86) or healthy comparison subjects (n = 56) completed 7 days of ecological momentary assessment (EMA) reports of location and behavior, and simultaneous GPS locations were tracked every five minutes. We found that GPS-derived indicators of average distance travelled overall and distance from home, as well as percent of GPS samples at home were highly correlated with EMA reports of location at the day- and week-averaged level. GPS-based mobility indicators were lower in schizophrenia with medium to large effect sizes. Less GPS mobility was related to greater negative symptom severity, particularly diminished motivation, whereas greater GPS mobility was weakly associated with more community functioning. Neurocognition, depression, and positive symptoms were not associated with mobility indicators. Therefore, passive GPS sensing could provide a low-burden proxy measure of important outcomes in schizophrenia, including negative symptoms and possibly of functioning. As such, passive GPS sensing could be used for monitoring and timely interventions for negative symptoms in young persons at high risk for schizophrenia.
High efficiency wide input extreme output (WIEO) tapped inductor buck–boost converter for high power LED lighting
Authors: Pal Somnath , Singh Bhim , Shrivastava Ashish 
Published: November 2019

A power factor corrected single switch tapped‐inductor buck–boost converter is proposed to achieve improved efficiency in extreme step‐up and step‐down conditions. This new and modified topology is having diode‐tapped and switch‐tapped configurations for step‐down and step‐up modes of operation, respectively. The proposed modified buck–boost converter is designed to operate in critical conduction mode (CrCM) to achieve quasi‐resonant operation. Both the buck and boost functionalities of the buck–boost converter are analysed using state space analysis with closed loop stability under varying input and output conditions. Several advantages and necessity of tapped versions are discussed and implemented under wide input and extreme output (WIEO) conditions. Two different prototypes are developed at extreme buck and boost levels to establish the benefits of the proposed arrangements. The efficiency improvement of the proposed converter is compared with the conventional buck–boost converter. The achieved efficiency of diode‐tapped buck mode and switch‐tapped boost mode is found 95% and total harmonic distortion is observed only 4% at 230 V AC mains for a prototype of 150 W, which is much improved results as compared to the previous research work on the tapped‐inductor converter.
Ultrasensitive immunosensor for AFP detection based on Cu2 O to generate electrical signals
Authors: Zhao Chulei , Cao Kaihang , Ma Chaoyun , Li Wenjun , Song Yiju , Qiao Xiuwen , Hong Chenglin 
Published: November 2019

In this experiment, a Cu2 O spherical nanoparticle was reduced by hydrothermal reaction to prepare a label‐free electrochemical immunosensor based on a novel signal amplification strategy. Multi‐walled carbon nanotubes are a platform that combines cuprous oxide with carbon nanotubes. Nanogold was modified on the surface of cuprous oxide nanospheres by electrostatic adsorption to further amplify the electrochemical signal and link‐supported anti‐alpha‐fetoprotein (AFP). Under optimal conditions, the proposed immunosensor has a wide linear range from 0.001 to 40 ng/ml, with a detection limit as low as 0.33 pg/ml (S /N = 3). Furthermore, the proposed label‐free immunosensor has been used to determine AFP in human serum with satisfactory results. At the same time, it has good reproducibility, acceptable selectivity and long‐term stability, and has broad application prospects in biometric analysis.
Development of a Plasma-Based Assay to Measure the Susceptibility of Factor V to Inhibition by the C-Terminus of TFPIα
Authors: van Doorn Peter , Rosing Jan , Campello Elena , Middeldorp Saskia , Simioni Paolo , Meijers Joost C. M. , Hackeng Tilman M. , Castoldi Elisabetta 
Published: November 2019

Abstract
Background Factor V (FV) is proteolytically activated to FVa, which assembles with FXa in the prothrombinase complex. The C-terminus of tissue factor pathway inhibitor-α (TFPIα) inhibits both the activation and the prothrombinase activity of FV(a), but the pathophysiological relevance of this anticoagulant mechanism is unknown. FV Leiden (FVL) is less susceptible to inhibition by TFPIα, while overexpression of FV splicing variants with increased affinity for TFPIα (FV-short) causes bleeding.
Objective This study aims to develop a plasma-based assay that quantifies the susceptibility of FV(a) to inhibition by the TFPIα C-terminus.
Materials and Methods FV in highly diluted plasma was preactivated with FXa in the absence or presence of the TFPIα C-terminal peptide. After adding prothrombin, thrombin formation was monitored continuously with a chromogenic substrate and prothrombinase rates were obtained from parabolic fits of the absorbance tracings. TFPI resistance was expressed as the ratio of the prothrombinase rates with and without peptide (TFPIr).
Results The TFPIr (0.25–0.34 in 45 healthy volunteers) was independent of FV levels. The TFPIr increased from normal individuals (0.29, 95% confidence interval [CI] 0.28–0.31) to FVL heterozygotes (0.35, 95% CI 0.34–0.37) and homozygotes (0.39, 95% CI 0.37–0.40), confirming TFPI resistance of FVL. Two individuals overexpressing FV-shortAmsterdam had markedly lower TFPIr (0.16, 0.18) than a normal relative (0.29), in line with the high affinity of FV-short for TFPIα.
Conclusion We have developed and validated an assay that measures the susceptibility of plasma FV to the TFPIα C-terminus. Once automated, this assay may be used to test whether the TFPIr correlates with thrombosis or bleeding risk in population studies.
How socio‐demographic and familiar circumstances are associated with total and domain‐specific sedentary behaviour in youth? The UP&DOWN study
Authors: Cabanas‐Sánchez Verónica , Esteban‐Cornejo Irene , Izquierdo‐Gómez Rocío , Padilla‐Moledo Carmen , Castro‐Piñero José , Veiga Óscar L. 
Published: November 2019

AbstractObjective: The aims of the present study were to analyze the associations between the socio‐demographic and familiar circumstances with: (i) the total leisure‐time sedentary behavior (SB) assessed by accelerometry, and (ii) the domain‐specific leisure‐time SB (i.e., screen‐based, educational‐based, social‐based, and other‐based SB), in a sample of Spanish youth. Method: The sample consisted of 1,543 youth (12.02 ± 2.51 years) included in the UP&DOWN study. SB was evaluated by accelerometry and questionnaire. Nationality, location of school, type of school, socio‐economic status, parental educational level, parental occupation status, family structure, number of siblings and position among siblings were self‐reported by participants or their parents. Linear mixed models, including school and city as random effects, were performed. Results: Several associations were found; however, socio‐demographic and family circumstances differently associated with SB according to the domain‐specific SB, the sex and the type of day. For example, participants with a father holding a high‐skilled occupation spent lower time in screen‐based SB during weekdays; and mother occupation status of high qualification was related to higher educational‐based SB in boys. Having three or more sibling was associated with lower total SB in boys, while having an obese mother was related to higher screen‐based SB on weekends both in boys and girls. Conclusions: Socio‐demographic and familiar circumstances are associated with SB in young people, so future interventions should consider multiple and sex‐specific factors for reduce SB of young people, focusing especially on youth with a low number of siblings and with parents holding low‐skilled employments.
Resonant inelastic x-ray scattering study of

α

-RuCl3: a progress report
Authors: Lebert Blair W , Kim Subin , Bisogni Valentina , Jarrige Ignace , Barbour Andi M , Kim Young-June 
Published: November 2019

Abstract
Ru M3-edge resonant inelastic x-ray scattering (RIXS) measurements of

with 27 meV resolution reveals a spin–orbit exciton without noticeable splitting. We extract values for the spin–orbit coupling constant (

meV) and trigonal distortion field energy (

meV) which support the

nature of

. We demonstrate the feasibility of M-edge RIXS for 4d systems, which allows ultra high-resolution RIXS of 4d systems until instrumentation for L-edge RIXS improves.
Simulation of a Vacuum Evaporator for Propolis Production
Authors: Muharam Y , Sahlan M , Tiarrahman  , Aletheia S P 
Published: November 2019

Abstract
Propolis is a matter produced by honey bees. Propolis production is carried out through extraction with ethanol and dilution with water. In order to increase the propolis purity, ethanol and water need to be removed in the final product by vacuum evaporation. The evaporation process that has been utilized so far has not been able to regenerate ethanol properly and the propolis production capacity is yet in small amounts, so an optimization of evaporation process needs to be performed to increase the propolis production. The purpose of this study is to obtain an optimum condition of a vacuum extraction for propolis production. The method used is the numerical simulation of the extraction process that has been modeled mathematically. The model consists of mass balance, energy balance and momentum balance. The simulation results for the evaporator of 0.35 m in diameter and 0.18 m in fluid height show that the optimum condition is at 343 K and 5×10−3 atm with the evaporation time being about 13 hours.
The study explores the effect of onion (allium cepa l.) drying using hot air dehumidified by activated carbon, silica gel and zeolite
Authors: Djaeni M , Perdanianti A M 
Published: November 2019

Abstract
Dehumidified air can be used to reduce the drying time. A batch-type tray dryer with hot air dehumidified by three different desiccants (i.e. activated carbon, silica gel and zeolite) were carried out to determine the optimum drying time. This study concerns the comparison of the between those desiccants. One mm sliced onion were dried at controlled temperature (40°C, 50°C, 60°C and 70°C). The weight of the samples were measured every 10 minutes for two hours. Results indicate that hot air dehumidified by zeolite gives the shortest drying time compared to the activated carbon and silica gel. Page and modified Page models are the most suitable model to experiment with the value of R2
(0.8971 – 0.9588). The highest k value (0.6132934) is achieved through the treatment at temperature 70°C using zeolite.
Low Temperature Enzymatic Hydrolysis (LTEH) and Fermentation for Bioethanol Generation from Suweg (Amorphophallus campanulatus B) Starch
Authors: Hargono H , Jos B , Kumoro AC , Haryani K 
Published: November 2019

Abstract
The ethanol generation through low temperature enzymatic hydrolysis (LTEH) of Suweg (Amorphophallus campanulatus B) starch followed by anaerobic fermentation using Saccharomyces cerevisiaehas been studied. Granular starch hydrolyzing enzyme (GSHE) as Stargen TM 002 was used in the hydrolysis to degrade starch into reducing sugar at 30°C and pH 4. The concentration of Suweg starch was 200 g/L, concentration of enzyme were 1; 1.5 and 2% (w/w), respectively. The fermentation was carried out at pH 4.5 and 30 °C for 72 h employing yeast concentration of 1gL−1. The ideal state of the procedure was fermentation utilizing concentration of Suweg starch 200 g L−1, concentration enzyme 1.5% (w/w), pH 4.5 and 30°C, for 60 h, which came about reducing sugar grouping of 31.32 g/L and further used for ethanol generation. It was discovered that most extreme ethanol fixation and profitability 13.12 g L−1 and 0.3727 gL−1h−1, separately. Although the result shows that Suweg starch is a potential raw material for ethanol generation, further investigations are required in both generation sustainability and techno-economical considerations.
Production of Fish Feed from Soy Residue and Shrimp Waste using Tapioca as Binding Agent
Authors: Sumardiono S , Siqhny Z D 
Published: November 2019

Abstract
The most used fish feed in cultivation activities is commercial feed that spends most of total cultivation cost. One of the effort to solve this problem is providing homemade fish food. The pellet based on local waste raw materials can reduce dependency of commercial fish feed. One of the local wastes that can be used is soy residue and shrimp waste. Tapioca is used as a binding agent for fish pellet. The aim of the research was to study the effect of raw material composition and binding agent concentration on proximate value, performance and mechanical strength. The research was conducted in several steps such as raw materials pretreatment, the experiment of raw materials and binding agent formulation, mixing, extrusion, prilling process, drying process, and product analysis (proximate and performance analysis). There are five formulations of raw materials and three different of formulation on binding agents. The drying process was done in 50°C and the product was then analyzed. The result shows that formulation with 30% soy residue, 60% shrimp waste and 10% binding agent resulted in a product with good proximate value (11.23% moisture content, 17.64% ash, 1.33% fat, 25.10% fiber, 29.54% protein). Increasing the percentage of binding agents resulted in higher mechanical strength and higher performance.