bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying, Prioritizing and Visually Mapping Barriers to Injury Care in Rwanda: A Multi‐disciplinary Stakeholder Exercise
Authors: Odland Maria Lisa , Whitaker John , Nepogodiev Dmitri , Aling’ Carolyn Achieng’ , Bagahirwa Irene , Dushime Theophile , Erlangga Darius , Mpirimbanyi Christophe , Muneza Severien , Nkeshimana Menelas , Nyundo Martin , Umuhoza Christian , Uwitonze Eric , Steans Jill , Rushton Alison , Belli Antonio , Byiringiro Jean Claude , Bekele Abebe , Davies Justine 
Published: May 2020

AbstractBackgroundWhilst injuries are a major cause of disability and death worldwide, a large proportion of people in low‐ and middle‐income countries lack timely access to injury care. Barriers to accessing care from the point of injury to return to function have not been delineated.MethodsA two‐day workshop was held in Kigali, Rwanda in May 2019 with representation from health providers, academia, and government. A four delays model (delays to seeking, reaching, receiving, and remaining in care) was applied to injury care. Participants identified barriers at each delay and graded, through consensus, their relative importance. Following an iterative voting process, the four highest priority barriers were identified. Based on workshop findings and a scoping review, a map was created to visually represent injury care access as a complex health‐system problem.ResultsInitially, 42 barriers were identified by the 34 participants. 19 barriers across all four delays were assigned high priority; highest‐priority barriers were “Training and retention of specialist staff”, “Health education/awareness of injury severity”, “Geographical coverage of referral trauma centres”, and “Lack of protocol for bypass to referral centres”. The literature review identified evidence relating to 14 of 19 high‐priority barriers. Most barriers were mapped to more than one of the four delays, visually represented in a complex health‐system map.ConclusionOvercoming barriers to ensure access to quality injury care requires a multifaceted approach which considers the whole patient journey from injury to rehabilitation. Our results can guide researchers and policymakers planning future interventions.
Non‐mesh Desarda Technique Versus Standard Mesh‐Based Lichtenstein Technique for Inguinal Hernia Repair: A Systematic Review and Meta‐analysis
Authors: Mohamedahmed Ali Yasen Y. , Ahmad Hasham , Abdelmabod Areeg A. N. , Sillah Abdul Karim 
Published: May 2020

AbstractBackgroundThe aims of the present systematic review and meta‐analysis were to compare non‐mesh Desarda technique with standard mesh‐based Lichtenstein technique for inguinal hernia repair.MethodsA systematic literature search for RCTs comparing between DT and LT was conducted using electronic databases and Google scholar service. Studies were evaluated for recurrence and post‐operative complications. We pooled the data using fixed effects model and random effects model after assessing the heterogeneity among the included studies.ResultsA total number of 8 RCTs studies were included in this meta‐analysis with total number of 3177 patients divided between Desarda group and Lichtenstein group as follows: 1551 patients and 1,626 patients, respectively. There was no difference in terms of recurrence between the Desarda repair and Lichtenstein repair groups [P = 0.44]. There was a lower rate of overall post‐operative complications [P = 0.003], seroma [P = 0.0004] and surgical site infections (SSIs) [P = 0.04] in the Desarda group.ConclusionDT and LT were found to have comparable results in terms of recurrence rate, haematoma formation, testicular atrophy and time to return to normal daily activity/work. DT is superior to LT in terms of reducing post‐operative mesh‐attributed complications, such as SSI and Seroma formation.
Middle and Distal Common Carotid Artery Stenting: Long-Term Patency Rates and Risk Factors for In-Stent Restenosis
Authors: Vértes Miklós , Nguyen Dat T. , Székely György , Bérczi Ákos , Dósa Edit 
Published: May 2020

Abstract
Purpose
In the absence of literature data, we aimed to determine the long-term patency rates of middle/distal common carotid artery (CCA) stenting and to investigate predisposing factors in the development of in-stent restenosis (ISR).

Materials and Methods
Fifty-one patients (30 males, median age 63.5 years), who underwent stenting with 51 self-expandable stents for significant (≥ 60%) stenosis of the middle/distal CCA, were analyzed retrospectively. Patient (atherosclerotic risk factors, comorbidities, medications), vessel (elongation), lesion (stenosis grade, length, calcification, location), and stent characteristics (material, diameter, length, fracture) were examined. Duplex ultrasonography was used to monitor stent patency. The Mann–Whitney U and Fisher’s exact tests, Kaplan–Meier analyses, and a log-rank test were used statistically.

Results
The median follow-up time was 35 months (interquartile range, 20–102 months). Significant (≥ 70%) ISR developed in 14 patients (27.5%; stenosis, N = 10; entire CCA occlusion, N = 4). Primary patency rates were 98%, 92%, 83%, 73%, and 61% at 6, 12, 24, 60, and 96 months, respectively. Reintervention was performed in six patients (11.8%) with nonocclusive ISR. Secondary patency rates were 100% at 6 and 12 months and 96% at 24, 60, and 96 months. In-stent restenosis developed more frequently (P < .001) in patients with hyperlipidemia; primary patency rates were also significantly worse (Chi-square, 11.08; degrees of freedom, 1; P < .001) in patients with hyperlipidemia compared to those without.

Conclusion
Stenting of the middle/distal CCA can be performed with acceptable patency rates. If intervention is unequivocally needed, patients with hyperlipidemia will require closer follow-up care.

Level of Evidence
Level 3, Local non-random sample.
New fat-tail normality test based on conditional second moments with applications to finance
Authors: Jelito Damian , Pitera Marcin 
Published: May 2020

AbstractIn this paper we introduce an efficient fat-tail measurement framework that is based on the conditional second moments. We construct a goodness-of-fit statistic that has a direct interpretation and can be used to assess the impact of fat-tails on central data conditional dispersion. Next, we show how to use this framework to construct a powerful normality test. In particular, we compare our methodology to various popular normality tests, including the Jarque–Bera test that is based on third and fourth moments, and show that in many cases our framework outperforms all others, both on simulated and market stock data. Finally, we derive asymptotic distributions for conditional mean and variance estimators, and use this to show asymptotic normality of the proposed test statistic.
Tetraspanin CD53: an overlooked regulator of immune cell function
Authors: Dunlock V. E. 
Published: May 2020

AbstractTetraspanins are membrane organizing proteins that play a role in organizing the cell surface through the formation of subcellular domains consisting of tetraspanins and their partner proteins. These complexes are referred to as tetraspanin enriched microdomains (TEMs) or the tetraspanin web. The formation of TEMs allows for the regulation of a variety of cellular processes such as adhesion, migration, signaling, and cell fusion. Tetraspanin CD53 is a member of the tetraspanin superfamily expressed exclusively within the immune compartment. Amongst others, B cells, CD4+ T cells, CD8+ T cells, dendritic cells, macrophages, and natural killer cells have all been found to express high levels of this protein on their surface. Almost three decades ago it was reported that patients who lacked CD53 suffered from an increased susceptibility to pathogens resulting in the clinical manifestation of recurrent viral, bacterial, and fungal infections. This clearly suggests a vital and non-redundant role for CD53 in immune function. Yet, despite this striking finding, the specific functional roles of CD53 within the immune system have remained elusive. This review aims to provide a concise overview of the published literature concerning CD53 and reflect on the underappreciated role of this protein in immune cell regulation and function.
Cell fusing agent virus (Flavivirus) infection in Aedes aegypti in Texas: seasonality, comparison by trap type, and individual viral loads
Authors: Martin Estelle , Tang Wendy , Briggs Cierra , Hopson Helena , Juarez Jose G. , Garcia-Luna Selene M. , de Valdez Megan Wise , Badillo-Vargas Ismael E. , Borucki Monica K. , Frank Matthias , Hamer Gabriel L. 
Published: May 2020

AbstractSouth Texas has experienced local transmission of Zika virus and of other mosquito-borne viruses such as chikungunya virus and dengue virus in the last decades. Using a mosquito surveillance program in the Lower Rio Grande Valley (LRGV) and San Antonio, TX, from 2016 to 2018, we detected the presence of an insect-specific virus, cell fusing agent virus (CFAV), in the Aedes aegypti mosquito population. We tested 6,326 females and 1,249 males from the LRGV and 659 females from San Antonio for CFAV by RT-PCR using specific primers. Infection rates varied from 0 to 261 per 1,000 mosquitoes in the LRGV and 115 to 208 per 1,000 in San Antonio depending on the month of collection. Infection rates per 1,000 individuals appeared higher in females collected from BG Sentinel 2 traps compared to Autocidal Gravid Ovitraps, but the ratio of the percentage of infected pools did not differ by trap type. The natural viral load in individual males ranged from 1.25 x 102 to 5.50 x 106 RNA copies and in unfed females from 5.42 x 103 to 8.70 x 106 RNA copies. Gravid females were found to harbor fewer viral particles than males and unfed females.
Predictors of voluntary and compulsory admissions after psychiatric emergency consultation in youth
Authors: So Pety , Wierdsma André I. , Kasius Marianne C. , Cornelis Jurgen , Lommerse Marion , Vermeiren Robert R. J. M. , Mulder Cornelis L. 
Published: May 2020

AbstractAs hospital beds are scarce, and emergency admissions to a psychiatric ward are major life-events for children and adolescents, it is essential to have insight into the decision-making process that leads to them. To identify potentially modifiable factors, we, therefore, studied the contextual and clinical characteristics associated with the voluntary and compulsory emergency admission of minors. We used registry data (2008–2017) on 1194 outpatient emergencies involving children aged 6–18 who had been referred to the mobile psychiatric emergency service in two city areas in The Netherlands. Demographic and contextual factors were collected, as well as clinical characteristics including diagnoses, psychiatric history, Global Assessment of Functioning (GAF), and the Severity of Psychiatric Illness (SPI) scale. Logistic regression analyses were used to identify factors that predict voluntary or compulsory admission. Of 1194 consultations, 227 (19.0%) resulted in an admission, with 137 patients (11.5%) being admitted voluntarily and 90 (7.5%) compulsorily. Independently of legal status, the following characteristics were associated with admission: severity of psychiatric symptoms, consultation outside the patient’s home, and high levels of family disruption. Relative to voluntary admission, compulsory admission was associated with more severe psychiatric problems, higher suicide risk, and prior emergency compulsory admission. Two potentially modifiable factors were associated with psychiatric emergency admission: the place where patients were seen for consultation, and the presence of family problems. Psychiatric emergency admissions may be reduced if, whenever possible, minors are seen in their homes and if a system-oriented approach is used.
Heterogeneity and chimerism of endothelial cells revealed by single-cell transcriptome in orthotopic liver tumors
Authors: Zhao Qi , Molina-Portela Maria del Pilar , Parveen Asma , Adler Alexander , Adler Christina , E Hock , Wang Wei , Ni Min , Wei Yi , Atwal Gurinder , Mohrs Markus , Thurston Gavin , Eichten Alexandra 
Published: May 2020

AbstractThe liver is a common host organ for cancer, either through lesions that arise in liver epithelial cells [e.g., hepatocellular carcinoma (HCC)] or as a site of metastasis by tumors arising in other organs (e.g., colorectal cancer). However, the changes that occur in liver stromal cells in response to cancer have not been fully characterized, nor has it been determined whether the different sources of liver cancer induce distinct stromal changes. Here, we performed single-cell profiling of liver stromal cells from mouse models of induced spontaneous liver cancer or implanted colorectal liver metastases, with a focus on tumor endothelial cells (ECs). While ECs in liver tissue adjacent to cancerous lesions (so-called adjacent normal) corresponded to liver zonation phenotypes, their transcriptomes were also clearly altered by the presence of a tumor. In comparison, tumor EC transcriptomes show stronger similarities to venous than sinusoidal ECs. Further, tumor ECs, independent of tumor origin, formed distinct clusters displaying conserved “tip-like” or “stalk-like” characteristics, similar to ECs from subcutaneous tumors. However, they also carried liver-specific signatures found in normal liver ECs, suggesting an influence of the host organ on tumor ECs. Our results document gene expression signatures in ECs in liver cancer and show that the host organ, and not the site of tumor origin (liver versus colorectal), is a primary determinant of EC phenotype. In addition, primarily in tumors, we further defined a cluster of chimeric cells that expressed both myeloid and endothelial cell markers and might play a role in tumor angiogenesis.
Long-term prognosis after kidney donation: a propensity score matched comparison of living donors and non-donors from two population cohorts
Authors: Janki Shiromani , Dehghan Abbas , van de Wetering Jacqueline , Steyerberg Ewout W. , Klop Karel W. J. , Kimenai Hendrikus J. A. N. , Rizopoulos Dimitris , Hoorn Ewout J. , Stracke Sylvia , Weimar Willem , Völzke Henry , Hofman Albert , Ijzermans Jan N. M. 
Published: May 2020

Abstract
Background
Live donor nephrectomy is a safe procedure. However, long-term donor prognosis is debated, necessitating high-quality studies.

Methods
A follow-up study of 761 living kidney donors was conducted, who visited the outpatient clinic and were propensity score matched and compared to 1522 non-donors from population-based cohort studies. Primary outcome was kidney function. Secondary outcomes were BMI (kg/m2), incidences of hypertension, diabetes, cardiovascular events, cardiovascular and overall mortality, and quality of life.

Results
Median follow-up after donation was 8.0 years. Donors had an increase in serum creatinine of 26 μmol/l (95% CI 24–28), a decrease in eGFR of 27 ml/min/1.73 m2 (95% CI − 29 to − 26), and an eGFR decline of 32% (95% CI 30–33) as compared to non-donors. There was no difference in outcomes between the groups for ESRD, microalbuminuria, BMI, incidence of diabetes or cardiovascular events, and mortality. A lower risk of new-onset hypertension (OR 0.45, 95% CI 0.33–0.62) was found among donors. The EQ-5D health-related scores were higher among donors, whereas the SF-12 physical and mental component scores were lower.

Conclusion
Loss of kidney mass after live donation does not translate into negative long-term outcomes in terms of morbidity and mortality compared to non-donors.

Trial registration
Dutch Trial Register NTR3795.
Rejuvenating experienced teachers through Quality Teaching Rounds professional development
Authors: Gore Jennifer , Rickards Bernadette 
Published: May 2020

AbstractThe key premise of professional development (PD) is that learning to teach continues throughout teachers’ careers. And yet, experienced teachers are often portrayed in media and public policy as resistant to such learning and afraid of change. This paper seeks a more nuanced understanding of why experienced teachers might resist the prospect of PD by investigating their responses to an innovative research-based collaborative approach known as Quality Teaching Rounds (QTR). We chronicle a story of change, from initial reservations to deep engagement and professional renewal. Analysis of before-and-after interviews with 25 mid-to-late career teachers from 20 primary and secondary schools in New South Wales, Australia, revealed that three features of QTR were critical to teacher turnaround: the time afforded teachers to refocus on quality teaching; time to observe teaching and learning and be observed; and processes founded on trust in and respect for teachers. In essence, QTR inspired teachers to embrace the opportunity to enhance their individual and collective practice, and they were rejuvenated in the process. Accordingly, we argue that the problem of professional development uptake among experienced teachers may lie less in ageist assumptions about their resistance to change than in the nature of the PD on offer. When PD is meaningful, intellectually engaging, safe, and collegial, experienced teachers are eager to participate.
The Health Benefits of Autobiographical Writing: An Interdisciplinary Perspective
Authors: Valtonen Jussi 
Published: May 2020

AbstractA large body of experimental evidence in the empirical sciences shows that writing about life experiences can be beneficial for mental and physical health. While empirical data regarding the health benefits of writing interventions have been collected in numerous studies in psychology and biomedicine, this literature has remained almost entirely disconnected from scholarship in the humanities and cognitive neuropsychology. In this paper, I review the literature from psychological and biomedical writing interventions, connect these findings to views from philosophy, cognitive neuropsychology and narratology and argue that examining established regularities in how narratives are structured can shed further light on the psychological processes engaged during writing interventions. In particular, I argue that the narratological concept of conflict can be applied to resolve patterns of seemingly conflicting empirical findings in psychological studies. More generally, I propose that an interdisciplinary perspective can provide a broader theoretical basis for understanding the psychological processes underlying the health benefits of autobiographical writing and provide directions for future research in psychology and biomedicine.
Suppression of friction-induced-vibration in MDoF systems using tangential harmonic excitation
Authors: Liu Ningyu , Ouyang Huajiang 
Published: May 2020

AbstractThis paper investigates the effects of tangential harmonic excitation on the friction-induced-vibration in multi-degree-of-freedom systems that are coupled in the tangential and normal directions. A minimal two-degree-of-freedom system and a more complicated slider-on-disc system are considered. It is observed the friction-induced-vibration of the systems can be suppressed with the tangential harmonic excitation when the amplitude and frequency of the excitation are in certain ranges. The analytical method to determine the ranges where the systems are stabilized by the tangential excitation is established. To verify the analytical results, a great amount of computational effort is also made to simulate the time responses of systems in various combinations of values of the amplitude and frequency, by which the parameter ranges where the friction-induced vibration is suppressed can also be obtained. This research can provide theoretical guidance for the suppression of friction-induced-vibration in a real disc brake system by application of a tangential harmonic excitation.
Fukunaga–Koontz Convolutional Network with Applications on Character Classification
Authors: Gatto Bernardo B. , dos Santos Eulanda M. , Fukui Kazuhiro , Júnior Waldir S. S. , dos Santos Kenny V. 
Published: May 2020

AbstractSeveral convolutional neural network architectures have been proposed for handwritten character recognition. However, most of the conventional architectures demand large scale training data and long training time to obtain satisfactory results. These requirements prevent the use of these methods in a broader range of applications. As an alternative to cope with these problems, we present a new convolutional network for handwritten character recognition based on the Fukunaga–Koontz transform (FKT). Our approach lies in the assumption that Fukunaga–Koontz convolutional kernels can be efficiently learned from subspaces and directly employed to produce high discriminant features in a shallow network architecture. When representing image classes by subspaces, the within-class separability is reduced, since the subspaces form clusters in a low-dimensional space. To increase the between-class separability, we compute a discriminative space from the training subspaces using FKT. By learning convolutional kernels from subspaces, it is possible to extract representative and discriminative features from an image with only a few parameters. Another contribution of the proposed network is the use of pooling layers, which further improves its performance. The proposed method, called Fukunaga–Koontz Network (FKNet), is suitable for solving practical problems, especially when training and processing times are constraints. Four publicly available handwritten character datasets are employed to evaluate the advantages of FKNet. In addition, we demonstrate the flexibility of the proposed method by experiments on LFW dataset.
Measurement-induced geometric measures of correlations based on the trace distance for two-qubit X states
Authors: Walczak Zbigniew , Bauer Jarosław H. 
Published: May 2020

AbstractWe apply the modified Brodutch and Modi method of constructing geometric measures of correlations to obtain analytical expressions for measurement-induced geometric classical and quantum correlations based on the trace distance for two-qubit X states. Moreover, we study continuity of the classical and quantum correlations for these states. In particular, we show that these correlations may not be continuous.
i3PosNet: instrument pose estimation from X-ray in temporal bone surgery
Authors: Kügler David , Sehring Jannik , Stefanov Andrei , Stenin Igor , Kristin Julia , Klenzner Thomas , Schipper Jörg , Mukhopadhyay Anirban 
Published: May 2020

Abstract
Purpose
Accurate estimation of the position and orientation (pose) of surgical instruments is crucial for delicate minimally invasive temporal bone surgery. Current techniques lack in accuracy and/or line-of-sight constraints (conventional tracking systems) or expose the patient to prohibitive ionizing radiation (intra-operative CT). A possible solution is to capture the instrument with a c-arm at irregular intervals and recover the pose from the image.

Methods
i3PosNet infers the position and orientation of instruments from images using a pose estimation network. Said framework considers localized patches and outputs pseudo-landmarks. The pose is reconstructed from pseudo-landmarks by geometric considerations.

Results
We show i3PosNet reaches errors $$<\,0.05$$<0.05 mm. It outperforms conventional image registration-based approaches reducing average and maximum errors by at least two thirds. i3PosNet trained on synthetic images generalizes to real X-rays without any further adaptation.

Conclusion
The translation of deep learning-based methods to surgical applications is difficult, because large representative datasets for training and testing are not available. This work empirically shows sub-millimeter pose estimation trained solely based on synthetic training data.