bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-cell RNA-sequencing reveals pervasive but highly cell type-specific genetic ancestry effects on the response to viral infection
Authors: Randolph Haley E , Mu Zepeng , Fiege Jessica K , Thielen Beth K , Grenier Jean-Christophe , Cobb Mari S , Hussin Julie G , Li Yang I , Langlois Ryan A , Barreiro Luis B 
Published: December 2020

AbstractHumans vary in their susceptibility to infectious disease, partly due to variation in the immune response following infection. Here, we used single-cell RNA-sequencing to quantify genetic contributions to this variation in peripheral blood mononuclear cells, focusing specifically on the transcriptional response to influenza infection. We find that monocytes are the most responsive to influenza infection, but that all cell types mount a conserved interferon response, which is stronger in individuals with increased European ancestry. By comparing European American and African American individuals, we show that genetic ancestry effects on expression are common, influencing 29% of genes, but highly cell type-specific. Further, we demonstrate that much of this population-associated expression variation is explained bycisexpression quantitative trait loci, which are enriched for signatures of recent positive selection. Our findings establish commoncis-regulatory variants—including those that are differentiated by genetic ancestry—as important determinants of the antiviral immune response.
Performative seduction: how management consultants influence practices of leadership
Authors: Ford Jackie , Harding Nancy 
Published: December 2020

PurposeThis paper tracks how a policy recommended by management consultants becomes embedded as an integral part of leadership practice. It explores the launch of the concept of “talent management” by McKinsey & Company and how it becomes adopted as part of expected leadership practices in the English National Health Service. The use of Management Consultants globally has increased exponentially, and the paper considers this phenomenon and the ways in which management consultant advice influences public sector leadership and practice at local level.Design/methodology/approachA case study approach is adopted, focussing on the introduction of the concept of talent management into the English NHS, following the wider emergence of the concept through influential reports published by McKinsey & Company in the late 1990s. An analysis of the emergence of the concept is conducted drawing on this series of reports and the adoption of talent management policies and practices by the English government's Department of Health.FindingsThese influential reports by the management consultancy firm, McKinsey & Company, constituted an urgent need for this newly identified concept of talent management and the secrecy surrounding its reception. It is this mystery surrounding the decisions about a talent management strategy in the NHS and the concealment of decisions behind closed doors, which leads us to offer a theory of management consultants' influence on leaders as one of performative seduction.Originality/valueManagement consultancy is a vast business whose influence reaches deeply into public and private sector organisations around the world. Understanding of the variegated policies and practices that constitute contemporary modes of governance therefore requires comprehension of management consultants' role within those policies and practices. This paper argues that management consultants influence public sector leadership through insertion of their products into definitions of, and performative constitution of, local level leadership.
Validation of a noninvasive prognostic signature for allograft failure following BK virus associated nephropathy
Authors: Abuhelaiqa Essa , Snopkowski Catherine , Li Carol , Salvatore Steve , Lee John R. , Muthukumar Thangamani , Lee Jun B. , Hartono Choli , Ding Ruchuang , Seshan Surya V. , Suthanthiran Manikkam , Dadhania Darshana M. 
Published: December 2020

AbstractIdentifying kidney transplant recipients at risk for graft failure following BK virus nephropathy (BKVN) may allow personalization of therapy. We have reported that a noninvasive composite signature of urinary cell level of plasminogen activator inhibitor‐1(PAI‐1) mRNA and serum creatinine level, measured at the time of BKVN diagnosis, is prognostic of graft failure. In this investigation, we determined whether the composite signature is prognostic of graft failure in an independent cohort of 25 patients with BKVN. Of the 25 patients, 8 developed graft failure and 17 did not. We measured urinary cell levels of PAI‐1 mRNA, 18S rRNA, and BKV VP1 mRNA at the time of BKVN diagnosis and evaluated clinical parameters including Banff pathology scores, acute rejection, and graft function. The area under the receiver operating characteristic curve for the noninvasive composite signature was 0.95 (P < .001) for prognosticating graft failure. The previously reported threshold of −0.858 predicted graft failure with a sensitivity of 75% and a specificity of 94%. Our current study validates the use of composite signature and the threshold of −0.858 to identify those at risk for graft failure following BKVN diagnosis, and supports future studies utilizing the composite signature score to personalize treatment of BKVN.
Windows of vulnerability: Seasonal mismatches in exposure and resource identity determine ocean acidification’s effect on a primary consumer at high latitude
Authors: Kroeker Kristy J. , Powell Cassandra , Donham Emily M. 
Published: December 2020

AbstractIt is well understood that differences in the cues used by consumers and their resources in fluctuating environments can give rise to trophic mismatches governing the emergent effects of global change. Trophic mismatches caused by changes in consumer energetics during periods of low resource availability have received far less attention, although this may be common for consumers during winter when primary producers are limited by light. Even less is understood about these dynamics in marine ecosystems, where consumers must cope with energetically costly changes in CO2‐driven carbonate chemistry that will be most pronounced in cold temperatures. This may be especially important for calcified marine herbivores, such as the pinto abalone (Haliotis kamschatkana). H. kamschatkana are of high management concern in the North Pacific due to the active recreational fishery and their importance among traditional cultures, and research suggests they may require more energy to maintain their calcified shells and acid/base balance with ocean acidification. Here we use field surveys to demonstrate seasonal mismatches in the exposure of marine consumers to low pH and algal resource identity during winter in a subpolar, marine ecosystem. We then use these data to test how the effects of exposure to seasonally relevant pH conditions on H. kamschatkana are mediated by seasonal resource identity. We find that exposure to projected future winter pH conditions decreases metabolism and growth, and this effect on growth is pronounced when their diet is limited to the algal species available during winter. Our results suggest that increases in the energetic demands of pinto abalone caused by ocean acidification during winter will be exacerbated by seasonal shifts in their resources. These findings have profound implications for other marine consumers and highlight the importance of considering fluctuations in exposure and resources when inferring the emergent effects of global change.
Between Affects and Norms
Authors: Campello Filipe 
Published: December 2020

Abstract
This article seeks to explore the meaning of emotional content in a transnational public sphere, in particular with regard to the concept of solidarity. The main normative question that the author discusses here is how far it is possible – if it’s the case at all – to move beyond the basic structure of nation-linked patriotic feeling to solidarity as a transnational political emotion. He divides his argument into two steps. First, he analyzes how the concept of constitutional patriotism could be reframed around the contours of post-national contexts. He suggests that Hegel’s concept of patriotism as a political disposition can contribute to a transnational framework. In a second step, the author discusses solidarity as a transnational political emotion, arguing that one should have in view both its formative process and its contingencies in order to understand the institutional and symbolic mediation of affective contents of social praxis.
Hugo Grotius, Declaration of War, and the International Moral Order
Authors: Boisen Camilla 
Published: December 2020

Abstract
This article investigates the formal purpose of declaring wars for Hugo Grotius. Grotius was adamant that states always use justification in a duplicitous way to conceal their real motivation to go to war. As such, the purpose of declaration is not to assert the just cause of war. Rather, what any public declaration does, is provide recognition that confers legal validation to the disputing parties. The legal rules of war were described by the law of nations and occasionally permitted states to commit certain ‘war crimes’ with impunity. For Grotius, this was not a moral sanctioning of such crimes but rather a means to prevent the occurrence of wars, which such endless repudiations risked causing or exacerbating. Grotius’s concern for the effects of war is conspicuous; and recounting his maxim that war should always be a last resort, this article argues that declaration of war has a distinct moral purpose for Grotius. In fact, public declaration of war is, together with constraints on the conduct of war, a ‘principle of moderation’ Grotius insists should be upheld in times of war. Declaration of war gives the parties avenues to seek peace and reconciliation, and, therefore has a humanitarian purpose for Grotius by ultimately seeking to prevent the disparaging effects of war. Even in wars that do not demand a public declaration, such as those regulated by natural law such as punitive wars or defensive wars, Grotius cautions that declarations of war are advisable. The remaining lingering issue is how to engage with unlawful enemy combatants, such as pirates - a distinct problem that the international community still faces with increasing regularity. Grotius was certainly aware of the legal (and moral) consequences of recognising belligerency we cannot possible hope to build moral relations with, and, this article claims, ‘unlawful’ enemies ultimately demarcates the boundary of international society.
The Need to Make Sense of a Practice in Investment Arbitration: A Response to Eric De Brabandere
Authors: Marcoux Jean-Michel 
Published: December 2020

Abstract
In his article entitled ‘The (Ir)relevance of Transnational Public Policy in Investment Treaty Arbitration – A Reply to Jean-Michel Marcoux’, Eric De Brabandere argues that transnational public policy does not have any significant role to play in investment treaty arbitration, both as a matter of principle and as an avenue to address human rights violations by foreign investors. The present response suggests that a more fundamental point of disagreement between our positions relates to the role of the practice of tribunals in shaping legal norms in international investment law. Inspired by the ‘practice turn’ in the study of international law, it suggests that the relevance and the normativity of transnational public policy are constituted by the practice of tribunals. Addressing human rights violations as an integral part of transnational public policy can thus be considered as a potential evolution of this practice in investment arbitration.
Covid-19: Teleworking, Surveillance and 24/7 Work. Some Reflexions on the Expected Growth of Remote Work After the Pandemic
Authors: Manokha Ivan 
Published: December 2020

Abstract
The lockdowns imposed by most governments during the Covid-19 pandemic have resulted in an unprecedented increase in teleworking. This spike in remote work has generally been greeted with enthusiasm by both academic and non-academic commentators and there is now a widely shared view that employers should be encouraged to retain and enhance the teleworking arrangements in the post-pandemic period. This paper examines the spread and normalization of telework during the pandemic with reference to the growth of the 24/7 work culture and the blurring of boundaries between work and private lives that have been developing in the last two decades or so. It is argued that the rise in remote work during the crisis is contributing to the movement towards 24/7 work and to the collapse of the boundary between professional and private life, particularly as a result of remote employee surveillance that comes with telework. It also results in a new form of alienation – the alienation of workers from their private homes.
<p><strong><em>Cissus lombardiana</em></strong><strong> a new name for <em>Cissus ulmifolia</em> (Vitaceae)</strong></p>
Authors: KOTTAIMUTHU RAMALINGAM , BASU MUTHURAMALINGAM JOTHI , SATHIYADASH KULLAIYAN , KARTHIKEYAN VELUSWAMY 
Published: December 2020

Cissus Linnaeus (1753: 117) is the most speciose genus in the family Vitaceae and notable for its pantropical intercontinental disjunct pattern (Liu et al. 2013). According to the recent estimate, the genus is known to have 291 accepted species (POWO 2020) and it is widely distributed in tropical regions of Africa, Asia, Australia, Central and South America and Mexico (Wen 2007). The main characters delimiting Cissus from other Vitaceae genera are the well-developed, thick and undivided floral disks, tetramerous flowers, one-seeded berries, and seeds with a long and linear chalaza (Wen 2007). In South America, Cissus is represented by 64 species (Lombardi 2000, 2007, Rodrigues et al. 2014). Amongst C. ulmifolia (Baker 1871: 213) Planchon (1887: 552) that is a later homonym of an Italian fossil taxon Cissus ulmifolia Massalongo (1858: 80). While checking the literature and relevant websites for the availability of any synonyms, we found that C. allenii Croat (1977: 358) and C. serrulatifolia Williams (1962: 375) are listed as heterotypic synonyms of C. ulmifolia in Tropicos (2020) following Nelson (2010). However, C. allenii was synonymized under C. serrulatifolia by most of the workers (Govaerts 1999, Lombardi 2007, Morales 2015, POWO 2020, Raz & Zamora 2020) but C. ulmifolia was treated as a distinct species. So in order to ascertain the taxonomic status, we critically studied the protologues and digital specimens including types of these three species, we found that the characters of C. allenii are well within the range of C. serrulatifolia but C. ulmifolia differs from them by its 4-sided, distinctly winged stem (vs. stem terete, not winged or wingless in C. serrulatifolia) and the fruits ovoid or ovoid–subglobose, smooth (vs. obovoid or subpyriform, lenticellate in C. serrulatifolia). Since no other validly published legitimate name is available for this species (Lombardi 2007, Mota de Oliveira & Jansen-Jacobs 2016, POWO 2020), therefore, the authors propose Cissus lombardiana as a replacement name.
Quantitative Evaluation of Polarimetric Estimates from Scanning Weather Radars Using a Vertically Pointing Micro Rain Radar
Authors: Reinoso-Rondinel Ricardo , Schleiss Marc 
Published: December 2020

AbstractConventionally, Micro Rain Radars (MRRs) have been used as a tool to calibrate reflectivity from weather radars, estimate the relation between rainfall rate and reflectivity, and study microphysical processes in precipitation. However, limited attention has been given to the reliability of the retrieved drop size distributions (DSDs) from MRRs. This study sheds more light on this aspect by examining the sensitivity of retrieved DSDs to the assumptions made to map Doppler spectra into size distributions, and investigates the capability of an MRR to assess polarimetric observations from operational weather radars. For that, an MRR was installed near the Cabauw observatory in the Netherlands, between the International Research Center for Telecommunications and Radar (IRCTR) Drizzle Radar (IDRA) X-band radar and the Herwijnen operational C-band radar. The measurements of the MRR from November 2018 to February 2019 were used to retrieve DSDs and simulate horizontal reflectivity Ze, differential reflectivity ZDR, and specific differential phase KDP in rain. Attention is given to the impact of aliased spectra and right-hand-side truncation on the simulation of polarimetric variables. From a quantitative assessment, the correlations of Ze and ZDR between the MRR and Herwijnen radar were 0.93 and 0.70, respectively, while those between the MRR and IDRA were 0.91 and 0.69. However, Ze and ZDR from the Herwijnen radar showed slight biases of 1.07 and 0.25 dB. For IDRA, the corresponding biases were 2.67 and −0.93 dB. Our results show that MRR measurements are advantageous to inspect the calibration of scanning radars and validate polarimetric estimates in rain, provided that the DSDs are correctly retrieved and controlled for quality assurance.
Applicability of cone beam computed tomography gray values for estimation of primary stability of dental implants
Authors: Sheikhi Mahnaz , Karami Mehdi , Abbasi Somayeh , Moaddabi Amirhossein , Soltani Parisa 
Published: December 2020

Objective: To evaluate the relationship between bone density measured by computed tomography (CT) and cone beam computed tomography (CBCT) (Sirona’s Galileos scanner) with primary stability of dental implants. Material and methods: 20 fresh bovine femoral heads were prepared by removal of soft tissue, sectioning of the bone, and placement of markers for location and angulation of implants. Bone density of peri-implant areas was determined preoperatively by CT and CBCT scanning of the prepared bone samples represented by Hounsfield units (HUs) and gray values (GVs), respectively. Then, 60 implants in three sizes (diameter = 4 mm, length = 8, 10, and 12 mm) were inserted into the bones and maximum insertion torque (IT) was recorded. Osstell device was also used for determining the implant stability quotient (ISQ) for each implant. Statistical analysis was performed on the data (alpha = 0.05). Results: Mean ± SD values of GV, HU, and ISQ were 1592.75 ± 231.82, 675.26 ± 115.38 and 61.90 ± 10.14, respectively. Moreover, the most frequent IT limit was 30-35 Ncm (41.4%). Significant relationships were observed between HU and IT, GV and IT, HU and ISQ, GV and ISQ, and IT and ISQ in all implant sizes. Moreover, GV and HU also significantly correlated to each other. Conclusion: Bone density values in CBCT and CT scans are positively associated to primary stability of dental implants. Therefore, GVs obtained from Galileos CBCT scanner can be used for preoperative selection of edentulous sites which allow for better implant stability or locations which require further procedures for enhancing the success rate of dental implants.
KEYWORDSComputed tomography; Cone beam computed tomography; Dental implant.
Machinability of Zirconia Toughened Mica Glass Ceramics for Dental Restorations
Authors: Gali Sivaranjani , Chiru Suresh 
Published: December 2020

Objective: For a dental material to be machinable for CAD/CAM technology, it must offer convenient machining, under a given set of cutting conditions. Quantitative evaluation of machinability has been assessed in literature through various parameters such as tool wear, penetration rates, surface roughness, cutting force and power. A machinable ceramic will typically demonstrate a higher tool penetration rate with signs of reduced diamond tool wear and edge chipping. The purpose of this in vitro study was to evaluate the feasibility of machining an experimental ceramic, 20 wt.% zirconia reinforced mica glass ceramics (G20Z) for indirect dental restorations and compare the tool penetration rates of G20Z to commercially available dental ceramics, Presintered Zirconia (PSZ) and IPS emax CAD. Material and Methods: Precursors of base glass (SiO2 -Al2O3 -K2O -MgO-B2O3 -F) were melted at 15000C for 2 h in a platinum crucible and quenched in deionised water. The glass frit was ball milled with 20 wt. % YSZ (G20Z) and subject to two stage heat treatment in a muffle furnace. Specimens of G20Z (12 X 2 mm) were evaluated for their feasibility of machining under varying spindle speed, depth of cut, and feed rates. Influence of depth of cut, spindle speed and feed rate (vc=8000-16000 rpm, d=0.4-0.8 mm, f=0.1- 0.3 mm/tooth) on cutting forces, material response, surface roughness and tool wear were investigated. Tool penetration rates, tool wear and margin chipping were also evaluated and compared with Pre-sintered Zirconia (PSZ) and e.max CAD in a custom dental milling surveyor at 30,000 rpm with a load of 0.98 N under water lubrication for 6 min. Tool penetration rates were calculated as the ratio of length of cut and milling time with a measuring microscope and scanning electron microscope was used for tool wear and edge chipping. ANOVA and Tukey Kramer tests were used for statistically comparing the means of each group. Results: Spindle speed and feed rate play a significant role in influencing surface roughness, thrust force, cutting forces and tool wear. Penetration rates of G20Z (0.32 ±0.12 mm/min) was significantly greater than PSZ (0.26 ±0.06 mm/min) and IPS e.max CAD (0.21 ±0.05 mm/min). SEM observations reveal tool abrasion and edge chipping regardless of the ceramic type. Conclusion: High spindle speeds delivers low cutting forces with an average surface roughness of 1.61 µm, with abrasive wear of the tool insert and brittle fracture of zirconia mica glass ceramic composites. G20Z with its machinable nature demonstrates greater tool penetration rates than PSZ and IPS e.max CAD. Tool wear and edge chipping is seen in all the investigated ceramics.

Keywords
Machinability, Dental Ceramics, Mica Glass-Ceramics, Dental Zirconia, Tool penetration rates.
Counterpoint: Reassessing Ulughkhānī’s Arabic history of Gujarat
Authors: Balachandran Jyoti Gulati 
Published: December 2020

Abstract
Despite his familiarity with the well established Indo-Persian history‐writing traditions, ‘Abdullāh Muḥammad al-Makkī al-Āṣafī al-Ulughkhānī ‘Ḥājjī al-Dabīr’ (b. 1540) chose to write his history of the Gujarat Sultanate and of other Indo-Muslim polities in Arabic. Ulughkhānī consulted several Persian chronicles produced in Delhi and Ahmedabad, including Sikandar Manjhū’s Mir’āt-i Sikandarī (composed c. 1611) that has served as the standard history of the Gujarat Sultanate for modern historians. Despite its ‘exceptionalism’, Ulughkhānī’s early seventeenth-century Ẓafar al-wālih bi Muẓaffar wa ālihi has largely been seen as a corroborative text to Persian tawārīkh. This article re-evaluates the importance of Ulughkhānī’s Arabic history of Gujarat by situating the text and its author in the social, political and intellectual context of the sixteenth-century western Indian ocean. Specifically, it demonstrates how the several historical digressions in the text are not dispensable aberrations to his narrative but integral to Ulughkhānī’s expansive social horizons at the time of robust commercial, pilgrimage, diplomatic and scholarly connections between Gujarat and the Red Sea regions.