bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Pentosidine as Bone Quality Marker in Postmenopausal Breast Cancer Patients Receiving Aromatase Inhibitors
Authors: Shigematsu Hideo , Yoshiyama Tomoyuki , Yasui Daisuke , Ozaki Shinji 
Published: July 2020

Abstract
Background: Osteoporosis and fractures are important aromatase inhibitor (AI) related adverse events in postmenopausal women with hormone receptor positive breast cancer. An increment of pentosidine is associated with a deterioration of bone quality. In this study, pentosidine was evaluated in postmenopausal breast cancer patients receiving AIs. Methods: Fifty postmenopausal breast cancer patients receiving AIs were retrospectively evaluated. Sixteen patients were given a bone modifying agent (BMA) concomitant with AIs. Changes of pentosidine, bone turnover markers and bone mineral density (BMD) before and after 12 months of AI therapy were compared between BMA administered patients (BMA group) and a non-BMA group.Results: There was no significant difference between pentosidine low and high groups in regard to age, height, weight, BMD of femoral neck and lumbar spine, and bone turnover markers including TRACP-5b and BAP. In the non-BMA group, pentosidine was increased in 18 cases (53%), and the average change of pentosidine was 21.5% (95%CI; 0.23 to 42.7%, p=0.048). In the BMA group, pentosidine was increased in 2 two cases (13%), and the average change of pentosidine was -16.6% (95%CI; -30.6 to -2.6%, p=0.023). There was a significantly lower proportion of pentosidine-increased cases (p=0.0065) and decrease of pentosidine (p=0.021) in the BMA group compared to those in the non-BMA group. Conclusions: Pentosidine was an independent factor from risk factors of osteoporotic fracture. Pentosidine was increased with AI, however, BMA inhibits an AI-induced increase of pentosidine in postmenopausal breast cancer patients.
Prehospital quick Sequential Organ Failure Assessment for predicting prognosis in patients with sepsis or suspected sepsis: a population-based ORION registry
Authors: Hirose Tomoya , Katayama Yusuke , Ogura Hiroshi , Umemura Yutaka , Kitamura Tetsuhisa , Mizushima Yasuaki , Shimazu Takeshi 
Published: July 2020

Abstract
BackgroundIn 2016, the quick Sequential Organ Failure Assessment (qSOFA) was proposed for use as a simple screening tool for sepsis, with sepsis suspected at a score ≥ 2 points. In this study, we evaluated the effectiveness of prehospital qSOFA for predicting prognosis in patients with sepsis or suspected sepsis using the population-based Osaka Emergency Information Research Intelligent Operation Network (ORION) registry, which compiles prehospital ambulance data and in-hospital information.MethodsThe study enrolled 437,974 patients in the ORION registry from January 1 to December 31, 2016. We selected hospitalized patients with sepsis or suspected sepsis using the appropriate ICD 10 codes. We excluded the patients with i) missing data (outcome, Japan Coma Scale, respiratory rate, blood pressure), ii) respiratory rate ≥ 60/min, and iii) blood pressure ≥ 250 mmHg. These measures were evaluated by ambulance personnel when they first contacted the patient in the prehospital setting. The primary endpoint was discharge to death.ResultsIn total, 12,646 patients (median age: 78 [IQR: 65–85] years, male: n = 6760 [53.5%]) were eligible for our analysis. In a multivariable logistic regression analysis adjusted for confounding factors, the proportion of patients discharge to death was significantly higher for qSOFA positive (≥ 2 points) than negative (≤ 1 point) (265/2250 [11.78%] vs. 415/10,396 [3.99%]; adjusted odds ratio 2.909; 95% confidence interval 2.469–3.428, p < 0.0001). The specificity and sensitivity were 83.4% and 40.0%, respectively, and the area under the receiver operating characteristic curve for qSOFA positive was 0.61.ConclusionsqSOFA evaluated by emergency medical services personnel in the prehospital setting might be useful for predicting prognosis in patients with sepsis or suspected sepsis.
A randomized controlled trial of the effects of antenatal milk expression on breastfeeding among first-time mothers in China
Authors: chen yan , Meng Li-Ping , Zhang Jiao-Jiao , Guo Hong-Hua , zhang hongyu 
Published: July 2020

Abstract
Background

Limited research outside China suggest that antenatal milk expression in late pregnancy (AME) may promote breastfeeding. A few studies have evaluated the safety and efficacy of AME in women with diabetes in pregnancy, little or no evidence exists to explore its effects on breastfeeding self-efficacy and early breastfeeding, particularly in first-time mothers. The objective of this study was to explore the effect of AME on breastfeeding for the first-time mothers during the postpartum hospitalization.
Methods

A randomized controlled trial was conducted in a tertiary hospital in Haikou, Hainan. We recruited pregnant women who had completed 37 weeks of gestation and randomly assigned them to either the intervention group (n = 45) or the control group (n = 45). The pregnant women in the intervention group were advised to rhythmic self-massage of breasts three times daily at any time. The control group was given routine midwifery and obstetric care. The breastfeeding self-efficacy scale(BSES)was used to measure the self-efficacy of breastfeeding at 37 weeks, 38 weeks and the third day postpartum. The time to lactogenesis II and the rate of exclusive breastfeeding was measured three times every day by the researcher in the ward.
Results

Compared with the control group, the intervention group had higher breastfeeding self-efficacy scores measured by the scale of BSES(P < 0.05), the intervention group had higher exclusive breastfeeding rate on the first day, second day, third-day postpartum, and the difference was statistically significant༈P < 0.05). The time to lactogenesis II in the intervention group was earlier than that in the control group(P < 0.05).
Conclusions

Antenatal breast milk expression at term improved the confidence in the ability to breastfeed and produce milk postpartum, thus significantly improving the behavior of exclusive breastfeeding, and increasing the percentage of breastfed infants during their hospital stay, these infants were able to avoid infant formula milk in this important early period.
A Novel FN-MdV Pathway and Its Role in Cerebellar Multimodular Control of Sensorimotor Behavior
Authors: Wang Xiaolu , Yu Si-yang , Ren Zhong , De Zeeuw Chris , Gao Zhenyu 
Published: July 2020

Abstract
The cerebellum is crucial for various associative sensorimotor behaviors. Delay eyeblink conditioning (DEC) depends on the simplex lobule-interposed nucleus (IN) pathway, yet it is unclear how other cerebellar modules cooperate during this task. Here, we demonstrate the contribution of the vermis-fastigial nucleus (FN) pathway in controlling DEC. We found that task-related modulations in vermal Purkinje cells and FN neurons predict conditioned responses (CRs). Coactivation of the FN and the IN allows for the generation of proper motor commands for CRs, but only FN output fine-tunes unconditioned responses. The vermis-FN pathway launches its signal via the contralateral ventral medullary reticular nucleus, which converges with the command from the simplex-IN pathway onto facial motor neurons. We propose that the IN pathway specifically drives CRs whereas the FN pathway modulates the amplitudes of eyelid closure during DEC. Thus, associative sensorimotor task optimization requires synergistic modulation of different olivocerebellar modules that provide unique contributions.
Quantitatively profiling acetylome of DNA repair proteins in early DNA damage
Authors: Li Shiqin , Zhou Lin , Liu Xinli , Shi Bingbing , Huang Tingting , An Hanxiang 
Published: July 2020

Abstract
Background：Lysine acetylation is a reversible regulated post-translational modification that can regulate the stability, localization, and function of proteins in multiple cellular processes. However, the regulative mechanism of acetylation on the repair proteins in the early DNA damage is not fully understood. Methods：We performed a global proteome and acetylome of DNA repair proteins in DNA damage in 1 h after treated with epirubicin by using high affinity enrichment and high-resolution liquid chromatography–tandem mass spectrometry approaches. Results: 190 Kac sites in 50 repair proteins were identified in cells treated with epirubicin as compared to the control. 42 acetylated lysine sites and 24 deacetylated lysine sites were observed in 21 and 16 repair proteins, respectively. 7 repair proteins simultaneously contained both acetylated and deacetylated lysine sites. 11 acetylation sites were located in the function domains of 7 repair proteins that might reveal mechanisms by which acetylations alter DDR protein function. In 17 repair proteins, the induced acetylation changes were for the first time identified in the present study. Conclusion: The proteome and acetylome results indicated that fast acetylation or deacetylation on these repair proteins might play a critical role in the early DNA damage repair process.
Clinical Characteristics and Outcomes of Influenza A and B Virus Infection in Adult Australian Hospitalised Patients
Authors: Sharma Yogesh , Horwood Chris , Hakendorf Paul , Thompson Campbell 
Published: July 2020

Abstract
Background
Influenza B is often perceived as a less severe strain of influenza. The epidemiology and clinical outcomes of influenza B have been less thoroughly investigated in hospitalised patients. The aim of this study was to describe clinical differences and outcomes between influenza A and B admitted over period of four years.
Methods
We retrospectively collected data of all laboratory confirmed influenza patients ≥18 years at two tertiary hospitals in South Australia. Patients were confirmed as influenza positive if they had a positive polymerase-chain-reaction (PCR) test of a respiratory specimen. Complications during hospitalisation along with inpatient mortality were compared between influenza A and B. In addition, 30 day mortality and readmissions were compared. Logistic regression model compared outcomes after adjustment for age, Charlson index, sex and creatinine levels.
Results
Between January 2016-March 2020, 1846 patients, mean age 66.5 years, were hospitalised for influenza. Of whom, 1630 (88.3%) had influenza A and 216 (11.7%) influenza B. Influenza B patients were significantly younger than influenza A. Influenza A patients were more likely be smokers with a history of chronic obstructive pulmonary disease (COPD) and ischaemic heart disease (IHD) than influenza B. Complications, including pneumonia and acute coronary syndrome (ACS) were similar between two groups, however, septic shock was more common in patients with influenza B. Adjusted analyses showed similar median length of hospital stay (LOS), in hospital mortality, 30-day mortality and readmissions between the two groups.
Conclusions
Influenza B is less prevalent and occurs mostly in younger hospitalised patients than influenza A. Both strains contribute equally to hospitalisation burden and complications.
Oral cenesthopathy proceeding dementia with Lewy body: a case report
Authors: Sawada Yuta , Konishi Yuki , Ikenouchi Atsuko , Yoshimura Reiji 
Published: July 2020

Abstract
Background
We herein report a case of oral cenesthopathy that proceeded dementia with Lewy body (DLB).
Case presentation:
A 70-year-old female presented with oral cenesthopathy. She was diagnosed with major depression/late-onset schizophrenia and treated with paroxetine and perospirone. Subsequently, she developed sever parkinsonism. Her diagnosis changed to DLB based on clinical features and her magnetic resonance imaging, MIBG scintigraphy, and DAT scans. After tapering off paroxetine and perospirone, the patient was treated with donepezil and levodopa. The DLB symptoms, including oral cenesthopathy and parkinsonism, were relieved.
Conclusion
This case indicates that oral cenesthopathy may occur as an early symptom of DLB.
Mechanical performance and thermal shock resistance of alumina composites fabricated by temperature gradient spark plasma sintering
Authors: Sun Junlong , Zhao Wansheng , Zhang Rui , Changxia Liu 
Published: July 2020

Abstract
Temperature gradient spark plasma sintering technology (TGSPS) was used to fabricate alumina composites with addition of tremolite. The mathematics model of TGSPS was established using piecewise interpolation spline function. Liquid phase sintering took place in the sintering process. Vickers hardness, fracture toughness and flexural strength of the composites were measured. Microstructure observations on fracture surfaces of alumina composites were analyzed. Thermal shock resistance of alumina composites was investigated by measuring the strength retention after varying the temperature difference through the water-quench method. Results showed that the addition of tremolite could promote the liquid phases sintering of alumina composites, decrease the porosity, strength the grain boundaries, improve the mechanical properties, and thus contribute to the improvement in TSR of alumina composites.
MassARRAY Multigene Screening Combined with LDL-C and sdLDL-C Detection for more Favorable Outcomes in type 2 Diabetes Mellitus Therapy
Authors: Tian Yong , Wang Junhong , Liu Yanxiao , Luo Xiangguang , Yao Ziying , Xu Cheng , Zhao Xiaoyu 
Published: July 2020

Abstract
Background: To determine the clinical value of multigene polymorphisms, LDL-C and sdLDL-C on T2DM therapy.Methods: In total, 352 T2DM patients before and after treatment and 48 healthy individuals were enrolled in this study. LDL-C and sdLDL-C were detected in 352 T2DM patients and 48 healthy individuals by Quantimetrix Lipoprint System. The 11 gene polymorphisms—HTR3B (rs2276307, A>G), APOE (rs7412, c.526C>T), APOE (rs429358, c.388T>C), CYP2C9*3 (rs1057910, c.1075A>C), KIF6 (rs20455, c.2155T>C), HMGCR (rs17238540, T>G), HMGCR (rs17244841, A>T), ABCB1 (rs2032582, c.2677G > T/A), HTR7 (rs1935349, C>T), SLCO1B1 (rs4149056, c.521T>C), and CETP (rs708272, G>A)—were screened in these 352 T2DM patients by the Agena Bioscience MassARRAY system before therapy.Results: Genetic polymorphisms associated with T2DM and statin effects in pretreatment patients were detected, then results showed that all 11 genes had heterozygous mutation, and 7 genes had homozygous mutation in 352 T2DM patients, more specifically reflected that these gene polymorphisms were common in Chinese T2DM patients. LDL-C and sdLDL-C were detected before and after treatment, sdLDL mainly existed in T2DM patients, and T2DM patients had higher mean levels of sdLDL-C than healthy people. After pharmacotherapy, the coincidence rates of decreases in LDL-C and sdLDL-C levels were 88.35% (311/352) and 84.09% (296/352), consistent with patients in remission.Conclusions: Gene polymorphisms related to pharmacotherapy were common in Chinese T2DM patients. And the expression of LDL-C and sdLDL-C was consistent with the T2DM disease course. Combined multigene screening before therapy and LDL-C and sdLDL-C detection before and after therapy could better assist T2DM treatment.
A PEG-PLGA-based polymeric capsule as theranostic nanoplatform for active targeting atherosclerosis
Authors: Jiandong Chen , Sun Weixin , Li Xinzhu , Lu Xin , Yu Peng , Shen Le , Chen Xiaohu 
Published: July 2020

Abstract
Background Atherosclerosis plaque is a major cause of cardiovascular diseases across the globe, which is characterized by a gradual formation of atherosclerotic plaque, hardening, and narrowing of the arteries. Nano-materials can serve as powerful delivery platforms for atherosclerosis treatment. Herein we systematically developed polymeric capsule with active targeting property encapsulating curcumin (Cur) and C-C chemokine receptor type 2 with short-interfering RNA (CCR2-siRNA) for combined treatment, which was also loaded with Gd3+ for magnatic resonance imaging (MRI) and a near-infrared fluorochrome (IR780) for fluorescence imaging (FI).Results The resulting nano-capsule exhibited a favorable hydrodynamic size and negative surface charge. More importantly, the negative charge and active-targeting peptide resulted in enhanced accumulation of nano-capsule in the established atherosclerotic plaques, thereby achieving targeted drug release. The in vitro and in vivo results indicated the effective diagnostic and therapeutic sensitivity, which could promote the development of theranostics for clinical implementation.Conclusions This study demonstrated that chemotherapy combined with gene therapy can displayed synergistic effect in atherosclerosis treatment, which possessed efficient management of atherosclerosis.
AI-based Five-Year Survival Prediction and Prognosis of DNp73 Expression in Rectal Cancer Patients
Authors: Pham Tuan , Fan Chuanwen , Zhang Hong , Sun Xiao-Feng 
Published: July 2020

Abstract
Predictive and prognostic markers in oncology are important areas of clinical cancer research and play essential roles for optimal decision making on therapy and assessing treatment efficacy for precision medicine in cancer patients. While DNp73 has been thought as a biomarker in rectal cancer, its clinical significance is still controversial. Exploration on the role of DNp73 protein expression in rectal cancer is a challenging task because of the limitation of human-based pathology analysis of complex information in pathological images. In this paper, we investigated the power of DNp73 expression identified by immunohistochemistry as predictive and prognostic markers in a cohort of 143 rectal cancer patients from the Swedish rectal cancer trial of preoperative radiotherapy using state-of-the-art artificial intelligence (AI) for machine learning and classification. Average validation results show very high accuracy rates (greater than or equal to to 93%) for the 5-year prediction and prognosis of the rectal cancer patients either with or without preoperative radiotherapy. In comparison with the pathology-based analysis, where DNp73 did not provide any survival information (p > 0.05), not only the findings of the AI-based study are clinically significant, but also pave a new direction for the rapid exploration of biomarkers in oncology.
The Functional and Structural Changes of the Brain in Parkinson's Disease Patients with Mild Cognitive Impairment
Authors: bingjun ji , Ji Bingjun , Zhao Ting , Cui Xuan , Chen Jingtao , Wang Zhenyu 
Published: July 2020

Abstract
Background: Parkinson's disease (PD) is often associated with cognitive impairment. However, the neural mechanism of cognitive impairment is not clear. The present study investigated the functional and anatomic changes in PD patients with mild cognitive impairment (MCI) and their correlations with cognitive functions by the application of combined functional and structural analysis. Methods: T1-weighted magnetic resonance imaging (MRI) and resting-state functional MRI data were acquired from 23 PD patients with MCI (PD-MCI), 23 PD patients with normal cognitive function (PD-NCI), and 23 matched healthy controls (HC). The structural imaging data was analyzed by voxel-based morphometry (VBM) and surfaced-based morphometry (SBM) methods to assess the changes of gray matter density and cortical thickness, respectively. And the amplitude of low-frequency fluctuations (ALFF) analysis using resting-state functional imaging data to measure the spontaneous changes of brain activity. Their Correlations with neuropsychological assessments (e.g., Montreal cognitive assessment, MOCA; Mini-mental state examination, MMSE) were also examined. Results: Compared to the HC group, the PD-MCI patient group showed both decreased ALFF in the occipital regions (i.e., left middle occipital gyrus) and parietal regions (i.e., left precuneus) and increased ALFF in the right inferior frontal gyrus and bilateral hippocampus. Also, the PD-MCI patient group showed reduced gray matter density in the right inferior frontal gyrus and middle frontal gyrus. Cortical thinning in the left middle temporal gyrus and right superior temporal gyrus was found in the PD_MCI patient group relative to the control group. Furthermore, ALFF of the right hippocampus and gray matter density of right frontal gyrus was correlated with cognitive impairment (e.g., MOCA ), respectively. Cortical thickness of right superior temporal gyrus was also associated with cognitive deficit (e.g., MMSE ). Conclusion: MCI in PD is associated with widespread brain functional and structural alternations. The combination of functional and structural abnormalities may be related to subtle cognitive impairment in PD.
Survey of bereavement care at home-visit nursing stations in Japan
Authors: OZAWA Miwa , UCHINO Seiko , SEI Jungetsu , UEHARA Kazuyoshi 
Published: July 2020

Abstract
BackgroundWith a rapidly aging population, the importance of promoting end-of-life care at home has been pointed out. Home-visit nurses play an important role as professionals in charge of home care, and pre- and post- bereavement care for bereaved families is included in home-visit nursing services. However, bereaved families are not always provided with care after bereavement in Japan. This present study aims to investigate the relationship between the provision rates of pre- and post-bereavement care for the patient family and the demographics of home-visit nurses through a survey of home-visit nurses, and to clarify the details of post-bereavement care and the reasons why the care is employed, exploratorily through a survey of the managers of home-visit nursing stations.MethodsA self-rating anonymous questionnaire survey was conducted with 2,400 facilities (including 2,200 facilities randomly selected from among the members of Home-Visit Nursing Stations of the National Nursing Business Association). For the analysis, simple aggregation was used and the statistical processing employed SPSS ver21.0.ResultsA total of 680 valid responses were analyzed. The mean length of home-visit nursing experience was 10.6 years and that of hospital nursing experience was 15.2 years. The provision rate of post-bereavement care was 90% or higher in most of the identified items, excluding “Provided continued support/life planning until the family fully recovers social life”. For the provision of post-bereavement care, most items exceeded 70%, but excluding “Provided continued support until the family fully recovers social life”, and “Involved in building a life after bereavement”.Compared to the participants with less than 5 years of home-visit nursing experience, those with 10 years or longer experience had statistically significantly higher rates of providing post-bereavement care in more than half of the identified items. Home-visit nursing facilities with 24-hour services had statistically significantly higher rates of providing care in more than half of the items of both of pre- and post-bereavement care, compared to the facilities without 24-hour services. About 70% of the managers think that bereaved families need follow-up, and visited the families as a post-bereavement care.