bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coexistence of Nonvolatile Unipolar Memory and Volatile Threshold Resistance Switching In LaMnO3 Thin Films
Authors: Yin yanfeng , Zhang ying , Jia caihong , Zhang weifeng 
Published: March 2020

Abstract
Coexistence of nonvolatile unipolar memory and volatile threshold resistive switching was observed in Pt/LaMnO 3 /Pt system. Specifically, nonvolatile unipolar memory was achieved by applying a negative bias, while volatile threshold resistive switching was obtained at a positive bias. The formation/rupture of conducting filaments and insulator-metal transition are supposed to induce nonvolatile unipolar memory and volatile threshold resistive switching, respectively. The convenient transition between nonvolatile and volatile switching by polarity is very useful for applications in in-memory computing technology.
Bacteria-derived ferrichrome inhibits tumor progression in sporadic colorectal neoplasms and colitis-associated cancer
Authors: IWAMA TAKUYA , Fujiya Mikihiro , Konishi Hiroaki , Tanaka Hiroki , Murakami Yuki , Kunogi Takehito , Sasaki Takahiro , Takahashi Keitaro , Ando Katsuyoshi , Ueno Nobuhiro , Kashima Shin , Moriichi Kentaro , Tanabe Hiroki , Okumura Toshikatsu 
Published: March 2020

Abstract
BACKGROUND: Colorectal cancers develop through several pathways, including the adenoma–carcinoma sequence and colitis-associated carcinogenesis. An altered intestinal microflora has been reported to be associated with the development and progression of colorectal cancer via these pathways. We identified Lactobacillus casei -derived ferrichrome as a mediator of the bacterial anti-tumor effect of colorectal cancer cells through the upregulation of DDIT3. In this study, we investigated the anti-tumor effects of ferrichrome on precancerous conditions and cancer cells associated with sporadic as well as colitis-associated colorectal cancer. METHODS: SRB and MTT assays were performed to assess growth inhibition in vitro . Eighteen organoids were prepared from biopsy specimens obtained by colonoscopy. An AOM-DSS carcinogenesis model and xenograft model of colorectal cancer cells were generated for the assessment of the tumor suppressive effect of ferrichrome in vivo . RESULTS: Ferrichrome inhibited the cell growth of colorectal cancer cells in vitro and in in vivo xenograft models. Ferrichrome exerted a strong tumor-suppressive effect that was superior to that of currently available anti-tumor agents, including 5-FU and cisplatin, both in vitro and in vivo . The tumor-suppressive effect of the combination of ferrichrome and 5-FU was superior to that of single treatment with either drug. The tumor suppressive effects of ferrichrome were confirmed through the upregulation of DDIT3 in patient-derived organoids of adenoma and carcinoma. Ferrichrome inhibited the tumor progression in the AOM-DSS model while exhibiting no anti-inflammatory effect in the DSS-colitis model, suggesting that ferrichrome inhibited cancer cells, but not a precancerous condition, via the colitis-associated pathway. CONCLUSIONS: Ferrichrome exerts a tumor suppressive effect on precancerous conditions and cancer cells associated with sporadic as well as colitis-associated colorectal cancer. The anti-tumor effect of ferrichrome was mediated by the upregulation of DDIT3, and was superior to that of 5-FU or cisplatin. These results suggest that Lactobacillus brevis -derived ferrichrome may be a candidate anti-tumor drug for the treatment of colorectal neoplasms.
Medical School Curriculum And The Level Of Compassion Of Portuguese Medical Students
Authors: Santiago Luiz Miguel , Batptista Ana Teresa Sá Cachada , Maurício Katia , Siytangco-Johnson Sean 
Published: March 2020

Abstract
Objectives To evaluate and to compare the levels of compassion of students throughout the Integrated Master’s in Medicine (MIM) in Portuguese Universities and relating them to University’s formal curriculum.Methods Cross sectional study of the levels of compassion of 1st, 3rd and 5th year students (3rd, 4th and 5th years in the University of XX) by electronically appliance of the Jefferson Scale of Medical Empathy (student version), between October and November 2018. Curricular plans of each University was searched on the institutional sites. The percentages of Credit Units (CU) and EUROPEAN CREDIT TRANSFER SYSTEM (ECTS) were calculated for the concept and/ or pillars of compassion. Adequate descriptive and inferential statistics were defined with difference definition for p <0.03.Results Mean levels of compassion are numerically far from their maximum value (49), being different between sexes p<0.001, year of attendance, p=0.022 and university, p=0.026). The percentage of CU related to the compassionate approach is significantly different between faculties (p <0.001), but the percentage of ECTS is not different (p = 0.031).Discussion This is the first comparative study between Portuguese medical schools. The reduction in the levels ​​of compassion of future physicians is a matter of concern for medicine schools.Conclusion There are differences in the levels of compassion among the students of the var universities according to the year attended. There are no differences between the percentage values ​​of ECTS, according to the institutional websites. The measured value is generally favourable to student´s Compassion. Differences between Universities deserves future studies.
Optimal sensor placement for pipe burst detection in water distribution systems using cost–benefit analysis
Authors: Zhao Mengke , Zhang Chi , Liu Haixing , Fu Guangtao , Wang Yuntao 
Published: March 2020

Abstract
Fast detection of pipe burst in water distribution systems (WDSs) could improve customer satisfaction, increase the profits of water supply and more importantly reduce the loss of water resources. Therefore, sensor placement for pipe burst detection in WDSs has been a crucial issue for researchers and practitioners. This paper presents an economic evaluation indicator named as net cost based on cost–benefit analysis to solve the optimal pressure sensor placement problem. The net cost is defined as the sum of the normalized optimal detection uncovering rate and investment cost of sensors. The optimal detection uncovering rate and the optimal set of sensor locations are determined through a single-objective optimization model that maximizes the detection coverage rate under a fixed number of sensors. The optimal number of sensors is then determined by analyzing the relationship between the net cost and the number of sensors. The proposed method is demonstrated to be effective in determining both the optimal number of sensors and their locations on a benchmark network Net3. Moreover, the sensor accuracy and pipe burst flow magnitude are shown to be key uncertainties in determining the optimal number of sensors.
Linking flow velocity-regulated EPS production with early-stage biofilm formation in drinking water distribution systems
Authors: Liu Yanyan , Shan Rongrong , Chen Guowei , Liu Li 
Published: March 2020

Abstract
Hydrodynamics impacts interactions between microbes and their micro-habitats in aqueous systems, thus the study of hydrodynamics is key to understanding the formation and dynamics of biofilms. Yet mechanisms of how microbial responses to hydrodynamics regulate biofilm formation in drinking water distribution systems (DWDS) are underappreciated. Here, we investigated the linkage between early-stage biofilm formation and flow velocity fluctuations in a model DWDS. Results showed that an intermediate velocity (1.0 m/s) enhanced biofilm formation, with the highest biofilm/total cells ratio of 96.91% ± 2.26%. Moreover, the intermediate velocity promoted extracellular polymeric substances (EPS) release, accompanied with lowered zeta potential and elevated hydrophobicity of suspended cells, which could be responsible for surface aggregation. Shifts in biofilm community were observed along with hydrodynamics fluctuations. Intermediate velocity (1.0 m/s) stimulated the dominance of Proteobacteria (78.16%) along with the genus predominance of Pseudomonas, known to secrete large amounts of EPS favoring biofilm formation. Overall, this study provides new understanding of biofilm formation responding to hydrodynamic fluctuations in DWDS.
The Potential Prognostic Performance of Neutrophil CD64 and Monocyte HLA-DR in Patients with Complicated Intra-abdominal Infections
Authors: Dimitrov Evgeni , Halacheva Krasimira , Enchev Emil , Minkov Georgi , Yovtchev Yovcho 
Published: March 2020

Background:
Complicated intra-abdominal infections are still associated with a high risk of
an unfavorable outcome. Despite the equal treatment, the mortality rates in some patients’ populations
remain significant, especially when the impaired immune response is present.

Aim:
The object of this research is to analyze the impact of pro-inflammatory neutrophil CD64 and
anti-inflammatory monocyte HLA-DR on the final outcome.

Methods:
We have searched in the PubMed database, the literature relating the prognostic value of two
biomarkers - nCD64 and mHLA-DR in patients with complicated intra-abdominal infections and/or
sepsis.

Results:
Eighteen original studies with 2960 patients fulfilled our inclusion criteria. The data about
nCD64 that we found was contradictory, whereas low mHLA-DR expression showed good prognostic
value.

Conclusion :
Our review showed heterogeneous data about nCD64 survival prediction. Further investigations
with surgical patients exclusively are needed to evaluate its prognostic value in cIAIs. However,
we observed a good prognostic performance of low mHLA-DR expression. After a validation in
larger multicentre studies, mHLA-DR could be used as promising prognostic biomarker in cIAIs.
HISTOMETRIC AND ULTRASTRUCTURAL ORGANIZATION OF THE NERVIMUSCULAR TERMINALS OF SKELETAL MUSCLES AT A HYPOKINESIA
Authors: Yaschyshyn Z. M. , Popel S. L. 
Published: March 2020

The aim: to study the dynamics of histological and ultrastructural changes in muscle fibers and their neuromuscular endings under conditions of prolonged hypokinesia at different stages of ontogenesis.
Methods. Studied skeletal muscles and their peripheral nervous apparatus of laboratory male Wistar rats aged 30 to 270 days. The restriction of motor activity was carried out in special canister cells for 30, 60, 90, and 240 days (5 animals for each term). To determine the type of muscle fiber, the Nahlas histochemical method was used, the Kulchitsky method was used to detect myelinated nerve fibers, the Bilshovsky-Gros method and the electron microscopic method to identify neuromuscular endings.
Results. The data of histological and electron microscopic examination of skeletal muscle fibers and their neuromuscular endings under conditions of prolonged hypokinesia indicate their regular restructuring during the development of muscles, the formation of their synapses and structures that are associated with them at different stages of ontogenesis.
Conclusion. The study provides an in-depth understanding of the relative frequency and nature of the disturbance of the neuromuscular endings during prolonged hypokinesia and its effect on the dynamics of structural adjustment of individual types of muscle fibers in ontogenesis.
AN ELECTRONIC EXCEL-CALCULATOR FOR CALCULATING DENTAL CROWN VOLUMES
Authors: Bulbuk O. I. , Mazurenko V. V. , Rozhko M. M. , Bulbuk O. V. 
Published: March 2020

Previous studies have found that with increasing volume of hard tissues defect, the sensitivity of the restored structure to the physical and mechanical restoration characteristics is increasing too. Since existing volume determination techniques cannot be use in a clinical setting, this gives reason to consider the problem of volume determination dental hard tissue defects extremely important, and this research-relevant.
Aims of research. Develop and evaluate the possibility of using methods to determine dental crown volumes and volumes of defects in hard tooth tissue.
Materials and methods of research. For determination of crown volumes and defect volumes of hard tooth tissues for each group of teeth were used appropriate geometric models. Together with the built models, were performed the mathematical calculations to calculate their linear dimensions.
Results of the research. We have developed and substantiated the feasibility of using an electronic Excel calculator to calculate dental crown volumes in clinical settings.
Conclusions. Using our electronic Excel calculator to calculate tooth crown volumes and methods for determining the volume of dental hard tissue defects, in clinical settings we can objectify the diagnostic process in the presence of dental hard tissue defects.
Usability, Acceptability, and Effectiveness of Web-Based Conversational Agents to Facilitate Problem Solving in Older Adults: Controlled Study
Authors: Bennion Matthew Russell , Hardy Gillian E , Moore Roger K , Kellett Stephen , Millings Abigail 
Published: March 2020

Background
The usability and effectiveness of conversational agents (chatbots) that deliver psychological therapies is under-researched.

Objective
This study aimed to compare the system usability, acceptability, and effectiveness in older adults of 2 Web-based conversational agents that differ in theoretical orientation and approach.

Methods
In a randomized study, 112 older adults were allocated to 1 of the following 2 fully automated interventions: Manage Your Life Online (MYLO; ie, a chatbot that mimics a therapist using a method of levels approach) and ELIZA (a chatbot that mimics a therapist using a humanistic counseling approach). The primary outcome was problem distress and resolution, with secondary outcome measures of system usability and clinical outcome.

Results
MYLO participants spent significantly longer interacting with the conversational agent. Posthoc tests indicated that MYLO participants had significantly lower problem distress at follow-up. There were no differences between MYLO and ELIZA in terms of problem resolution. MYLO was rated as significantly more helpful and likely to be used again. System usability of both the conversational agents was associated with helpfulness of the agents and the willingness of the participants to reuse. Adherence was high. A total of 12% (7/59) of the MYLO group did not carry out their conversation with the chatbot.

Conclusions
Controlled studies of chatbots need to be conducted in clinical populations across different age groups. The potential integration of chatbots into psychological care in routine services is discussed.
BREVE DIÁLOGO ENTRE “SENTIDOS DO AMOR” E O PENSAMENTO DE MERLEAU-PONTY BRIEF DIALOGUE BETWEEN "SENTIDOS DO AMOR" AND THE THOUGHT BY MERLEAU-PONTY
Authors: Marton Silmara Lídia 
Published: March 2020

ResumoArte e filosofia assumidas em sua tarefa de provocar a expressão primordial do sentir-pensar, juntas, proporcionam uma compreensão mais ampla de nossa condição no mundo que, sua por sua vez, é feita de relações que não são puras mediante o exercício de um pensamento formal e lógico a dominar os objetos a sua volta, mas por relações de seres encarnados feitas de perspectivas que abrem e recobrem, continuamente. Nessa perspectiva, o texto se propõe a realizar um diálogo entre a arte do cinema a partir do filme “Sentidos do Amor”, dirigido por David Mackenzie e a filosofia de Merleau-Ponty, cuja abordagem fenomenológica nos desloca para uma percepção da radicalidade de nossa existência como corporeidade e possibilidade autêntica de produção de sentidos.Palavras-chave: Arte. Filosofia. Fenomenologia. Cinema. Sentidos. AbstractArt and philosophy assumed in their task of provoking the primordial expression of feeling-thinking, together, provide a broader understanding of our condition in the world which, in turn, is made of relationships that are not pure through the exercise of a thought formal and logical that dominate the objects around him, but by relationships of incarnated beings made of perspectives that open and cover, continuously. In this perspective, the text proposes to make a dialogue between the art of cinema from the film "Senses of Love", directed by David Mackenzie and the philosophy of Merleau-Ponty, whose phenomenological approuch moves us to a perception of the radicality of our existence as corporeity and authentic possibility of meaning production.Keywords: Art. Philosophy. Phenomenology. Cinema. Senses.
NA CONTRAMÃO DA MEDICALIZAÇÃO NA EDUCAÇÃO: DESNATURALIZAR E DESPATOLOGIZAR O FRACASSO ESCOLAR ON THE OPPOSITE WAY OF MEDICALIZATION IN EDUCATION: DENATURIZING AND DEPATHOLOGIZING SCHOOL FAILURE
Authors: Ferreira Danielle De Almeida Galante 
Published: March 2020

O objeto deste estudo são as dificuldades de escolarização interceptadas pela medicalização dos fenômenos educacionais em meio à produção ideológica dofracasso escolar. A investigação objetivou verificar a epidemia de diagnósticos e de tratamentos do suposto fracasso escolar na sociedade contemporânea; bem como pensar em formas de intervenção do problema da patologização e da caracterização do fracasso escolar que considerem a brincadeira como essencial para identificar asnecessidades do aprendiz. Por meio da revisão bibliográfica, almeja-se refletir acerca de alternativas à medicalização das dificuldades de aprendizagem na prática educacional e que resgatem o prazer em aprender. The object of this study is the difficulties of schooling intercepted by the medicalization of educational phenomena in the midst of the ideological production of school failure.The investigation aimed to verify the epidemic of diagnoses and treatments of the supposed scholastic failure in the contemporary society; as well as to think of ways ofintervention of the problem of the pathologization and the characterization of school failure that consider play as essential to identify the needs of the learner. Through thebibliographic review, it is sought to reflect on alternatives to the medicalization of learning difficulties in educational practice and that rescue the pleasure in learning.
Le rire des féministes
Authors: Laufer Laurie 
Published: March 2020

En France, dans le sillage du mouvement de Mai 68, émerge spontanément et joyeusement le Mouvement de Libération des Femmes (MLF), à l’initiative d’Antoinette Fouque et de Monique Wittig. Au cœur de leur débat, de leur relecture critique des textes freudiens et lacaniens se trouvent pensés à nouveau frais le discours et la théorie de la psychanalyse sur “La femme”, “le féminin”, “la sexualité féminine”, “la différence des sexes”. Les dogmes théoriques concernant “le continent noir” romantiquement évoqués ainsi par Freud sont revisités, voire renversés. Les querelles autour du terme même de “féminisme” produisent et ouvrent à d’autres discours.
Freud a toujours considéré que la théorie psychanalytique était open to revision et Lacan que la psychanalyse gagnerait à être en “extension”. Que se passe-t-il lorsque la théorie et la pratique psychanalytiques rencontrent les discours féministes? L’horizon s’ouvre-t-il pour le discours psychanalytique, sa théorie, sa pratique? Une ouverture, une révision peuvent-elle s’opérer? Un renversement du dogme, une nouvelle joie de la pratique analytique?
Carotid body tumor: what treating surgeon wants to know in radiological evaluation? – A case report
Authors: Sharma Shweta , Sharma Bharat Bhushan , Kapur Neeru , Joon Pawan , Aziz Mir Rizwan , Jha Dileep Kumar , Virmani Nitish , Zaffar Sadaf 
Published: March 2020

Background:
Carotid body tumors (CBTs) are benign, but they are quite controversial for the management because of their location and symptoms. Cervical CBTs are slightly uncommon paragangliomas. These are highly vascular tumors. Their location is at the bifurcation of common carotid artery (CCA) which is adjacent to many cranial nerves. Surgical management involves a lot of morbidity and mortality.

Case Report:
A 48-year-old female reported with painless small swelling on the right side of the neck region just below the angle of the mandible. The radiological evaluation by ultrasonography, contrast-enhanced computerized tomography, and magnetic resonance angiography revealed the swelling as carotid body tumor. The patient had been advised surgical management as presently the entity was almost without any symptoms.

Conclusion:
The cross-sectional imaging plays a great role in the diagnosis and management of CBTs as they are associated with many complications. The treating surgeon had to be very careful about surgical extirpation.
Delayed massive hemothorax from pulmonary laceration complicating rib fractures: a rare case presentation
Authors: Yee Lui Sze , Halim Nurkhairulnizam Abd , Abidin Ida Zaliza Zainol 
Published: March 2020

Background:
The incidence of delayed hemothorax from blunt chest trauma was only up to 7.4%, massive hemothorax being much rarer.

Case Presentation:
We report a case of this uncommon situation involving a 65-year old gentleman with alleged motor-vehicle accident (MVA) sustaining multiple right 2nd to 8th rib fractures. Despite initial in-patient monitoring, he presented to us again on Day-7 post-MVA with acute shortness of breath and chest pain. Chest radiograph showed homogenous opacity over right lung field with the blunting of costophrenic angle. Right thoracostomy tube drained 800 ml of frank blood upon insertion with a total of 1,250 ml within 12 hours. The patient was subsequently transferred to cardiothoracic center for definitive care.

Conclusion:
Therefore, the possibility of delayed sequelae following blunt chest trauma should be considered and communicated to the patient to encourage vigilance and home monitoring. Despite rarely requiring emergency surgery, delayed massive hemothorax is potentially life threatening.