bluuebunny/crossref_metadata_2025_split huggingface dataset:
LINC01123 facilitates proliferation, invasion and chemoresistance of colon cancer cells
Authors: Ye Shicai , Sun Bilan , Wu Weiyun , Yu Caiyuan , Tian Ting , Lian Zhongxiong , Liang Qianyi , Zhou Yu 
Published: July 2020

Abstract
Colon cancer is one of the major causes of cancer-related deaths worldwide. Long non-coding RNA (lncRNA) LINC01123 has been suggested to act as an oncogene in non-small cell lung cancer and a prognostic signature in head and neck squamous cell carcinoma. However, its role in colon cancer remains obscure. From TCGA database, LINC01123 was observed to be up-regulated in colon adenocarcinoma (COAD). Subsequently, the up-regulated LINC01123 was also detected in colon cancer cells. Functionally, LINC01123 could enhance cell proliferation, migration, invasion and angiogenesis. Moreover, the chemoresistance of colon cancer cells was verified to be promoted by LINC01123. Afterward, LINC01123 was found to bind with Ago2 and miR-34c-5p. Besides, miR-34c-5p was confirmed to inhibit the cellular process and chemoresistance of colon cancer cells. Then, VEGFA was disclosed to coexist with LINC01123 and miR-34c-5p in RNA-induced silencing complex. And TCGA database suggested that its expression was correlated with different stages of COAD. Moreover, it was uncovered that VEGFA could bind with miR-34c-5p and its expression positively correlated with LINC01123 expression. Finally, LINC01123 was proofed to regulate colon cancer progression and cells chemoresistance via VEGFA. In conclusion, LINC01123/miR-34c-5p/VEGFA axis promotes colon cancer malignancy and cells chemoresistance.
Dipeptidyl peptidase like 6 promoter methylation is a potential prognostic biomarker for pancreatic ductal adenocarcinoma
Authors: Zhao Xin , Cao Di , Ren Zhangyong , Liu Zhe , Lv Shaocheng , Zhu Jiqiao , Li Lixin , Lang Ren , He Qiang 
Published: July 2020

AbstractBackground: Hypermethylation of gene promoters plays an important role in tumorigenesis. The present study aimed to identify and validate promoter methylation-driven genes (PMDGs) for pancreatic ductal adenocarcinoma (PDAC). Methods: Based on GSE49149 and the PDAC cohort of The Cancer Genome Atlas (TCGA), differential analyses of promoter methylation, correlation analysis, and Cox regression analysis were performed to identify PMDGs. The promoter methylation level was assessed by bisulfite sequencing polymerase chain reaction (BSP) in paired tumor and normal tissues of 72 PDAC patients. Kaplan−Meier survival analyses were performed to evaluate the clinical value of PMDGs. Results: In GSE49149, the β-value of the dipeptidyl peptidase like 6 (DPP6) promoter was significantly higher in tumor compared with normal samples (0.50 vs. 0.24, P&lt;0.001). In the PDAC cohort of TCGA, the methylation level of the DPP6 promoter was negatively correlated with mRNA expression (r = −0.54, P&lt;0.001). In a multivariate Cox regression analysis, hypermethylation of the DPP6 promoter was an independent risk factor for PDAC (hazard ratio (HR) = 543.91, P=0.002). The results of BSP revealed that the number of methylated CG sites in the DPP6 promoter was greater in tumor samples than in normal samples (7.43 vs. 2.78, P&lt;0.001). The methylation level of the DPP6 promoter was moderately effective at distinguishing tumor from normal samples (area under ROC curve (AUC) = 0.74, P&lt;0.001). Hypermethylation of the DPP6 promoter was associated with poor overall (HR = 3.61, P&lt;0.001) and disease-free (HR = 2.01, P=0.016) survivals for PDAC patients. Conclusion: These results indicate that DPP6 promoter methylation is a potential prognostic biomarker for PDAC.
Elevated long noncoding RNA MALAT-1 expression is predictive of poor prognosis in patients with breast cancer: a meta-analysis
Authors: Wang Yanyan , Zhang Yujie , Hu Kaimin , Qiu Jili , Hu Yue , Zhou Meiqi , Zhang Suzhan 
Published: July 2020

Abstract
Accumulating evidence indicates that aberrant regulation of metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1), a long noncoding RNA (lncRNA), plays a vital role in tumorigenesis. However, its association with breast cancer has not been systematically evaluated. In the current study, a meta-analysis was conducted to clarify the association between MALAT-1 and the prognosis and clinicopathological features of breast cancer. Relevant literature published in several databases was searched. Hazard ratio (HR) and odds ratio (OR) with 95% confidence interval (CI) were calculated to evaluate the effect of MALAT-1 expression on the survival outcomes and clinicopathological features of breast cancer. A total of 12 studies involving 4106 patients were identified. Pooled HR demonstrated that elevated MALAT-1 expression significantly predicted unfavorable overall survival (HR = 2.06, 95% CI: 1.66–2.56, P&lt;0.0001) in patients with breast cancer. Subgroup analysis stratified by cancer type, sample size, and method of variance analysis also showed statistically significant associations. Additionally, the HR of patients with up-regulated MALAT-1 expression concerning disease-free survival (DFS), recurrence-free survival (RFS), and disease-specific survival (DSS) was 1.91 (95% CI: 1.53–2.39, P&lt;0.0001). Further, elevated MALAT-1 expression was positively correlated with the progesterone receptor (PR) status (OR = 1.47, 95% CI: 1.18–1.82). Thus, MALAT-1 is a promising biomarker for predicting survival outcomes in patients with breast cancer.
Which sample type is better for Xpert MTB/RIF to diagnose adult and pediatric pulmonary tuberculosis?
Authors: Lyu Mengyuan , Zhou Jian , Cheng Yuhui , Chong Weelic , Wu Kang , Fang Teng , Fu Tianbo , Ying Binwu 
Published: July 2020

Abstract
Objective: This review aimed to identify proper respiratory-related sample types for adult and pediatric pulmonary tuberculosis (PTB), respectively, by comparing performance of Xpert MTB/RIF when using bronchoalveolar lavage (BAL), induced sputum (IS), expectorated sputum (ES), nasopharyngeal aspirates (NPAs), and gastric aspiration (GA) as sample.
Methods: Articles were searched in Web of Science, PubMed, and Ovid from inception up to 29 June 2020. Pooled sensitivity and specificity were calculated, each with a 95% confidence interval (CI). Quality assessment and heterogeneity evaluation across included studies were performed.
Results: A total of 50 articles were included. The respective sensitivity and specificity were 87% (95% CI: 0.84–0.89), 91% (95% CI: 0.90–0.92) and 95% (95% CI: 0.93–0.97) in the adult BAL group; 90% (95% CI: 0.88–0.91), 98% (95% CI: 0.97–0.98) and 97% (95% CI: 0.95–0.99) in the adult ES group; 86% (95% CI: 0.84–0.89) and 97% (95% CI: 0.96–0.98) in the adult IS group. Xpert MTB/RIF showed the sensitivity and specificity of 14% (95% CI: 0.10–0.19) and 99% (95% CI: 0.97–1.00) in the pediatric ES group; 80% (95% CI: 0.72–0.87) and 94% (95% CI: 0.92–0.95) in the pediatric GA group; 67% (95% CI: 0.62–0.72) and 99% (95% CI: 0.98–0.99) in the pediatric IS group; and 54% (95% CI: 0.43–0.64) and 99% (95% CI: 0.97–0.99) in the pediatric NPA group. The heterogeneity across included studies was deemed acceptable.
Conclusion: Considering diagnostic accuracy, cost and sampling process, ES was a better choice than other sample types for diagnosing adult PTB, especially HIV-associated PTB. GA might be more suitable than other sample types for diagnosing pediatric PTB. The actual choice of sample types should also consider the needs of specific situations.
The ablation of gas clouds by blazar jets
Authors: Heil Jonathan , Zacharias Michael 
Published: July 2020

Context. Flaring activity in blazars can last for vastly different timescales, and it may be the result of density enhancements in the jet flow that result from the intrusion of an interstellar cloud into the jet.
Aims. We investigate the lightcurves expected from the ablation of gas clouds by the blazar jet under various cloud and jet configurations.
Methods. We derived the semi-analytical formulae describing the ablation process of a hydrostatic cloud and performed parameter scans of artificial set-ups over both cloud and jet parameter spaces. We then used parameters obtained from measurements of various cloud types to produce lightcurves of these cloud examples.
Results. The parameter scans show that a vast zoo of symmetrical lightcurves can be realized. Both cloud and emission region parameters significantly influence the duration and strength of the flare. The scale height of the cloud is one of the most important parameters as it determines the shape of the lightcurve. In turn, important cloud parameters can be deduced from the observed shape of a flare. The example clouds result in significant flares lasting for various timescales.
Indikatorische Freiräume und Grenzen in der Shuntchirurgie
Authors: Krönung Gerhard 
Published: July 2020

ZUSAMMENFASSUNGDie Zahl zukünftig möglicher Gefäßzugänge bei einem Patienten ist nicht nur durch den individuellen Pool shuntgeeigneter Venen begrenzt. Funktionelle Handicaps wie die fehlende Toleranz eines arteriovenösen Blutflusses, zentralvenöse Verschlüsse oder ein eingeschränktes OP-Spektrum reduzieren die Zahl weiter. Je kleiner die Zahl zukünftiger Gefäßzugänge wird, desto risikoreichere Verfahren zur Anlage eines Gefäßzuganges sind gerechtfertigt, insbesondere wenn Peritonealdialyse (PD) und/oder Nierentransplantation (NTx) nicht möglich sind.
Lösungsmöglichkeiten bei fehlgeschlagenen Osteosynthesen am distalen
Femur
Authors: Stillhard Philipp F. , Sommer Christoph 
Published: July 2020

ZusammenfassungDie Versorgung von distalen Femurfrakturen ist eine große Herausforderung.
Fehlgeschlagene Osteosynthesen müssen früh erkannt und revidiert werden. Wir
unterteilen die Ursachen für misslungene Osteosynthesen in dieser Region in
frühe sekundäre Instabilität mit Fehlstellung, Nonunion, Malunion und das
Vorliegen eines Infekts ein. Anhand von klinischen Beispielen zeigen wir in der
folgenden Arbeit mögliche Lösungsmöglichkeiten bei fehlgeschlagenen
Osteosynthesen am distalen Femur auf.
Noch zeitgemäß und aktuell? Optimierungspotenzial in der Ausbildung von nicht ärztlichem Assistenzpersonal zur Sedierungsüberwachung – Pilotprojekte Sedierungsfachkraft und teilvirtuelle Kurse
Authors: Nickl Stephan , Heitkamp Andreas 
Published: July 2020

ZusammenfassungLernen und berufliche Weiterqualifikation sind lebenslange Prozesse, die eine ständige Anpassung an die aktuellen Erfordernisse und Bedürfnisse der Teilnehmer und an den geltenden Stand der Lern- und Unterrichtstechnik erfordern.Mit diesen Überlegungen hat die reanitrain GmbH sowohl ein Konzept zur fachlichen Intensivierung der Ausbildung nicht ärztlichen Assistenzpersonals im Rahmen der Sedierungsüberwachung („Sedierungsfachkraft“) als auch teil-virtuelle, digitalisierte Kurskonzepte entwickelt.Die neuen Kurskonzepte werden nach aktuellem Stand sehr gut angenommen und momentan laufend evaluiert.
Die transforaminale sacrale Stressfraktur bei einem 33-jährigen Langstreckenläufer
Authors: Husen Martin 
Published: July 2020

ZusammenfassungLumbale und iliosacrale Schmerzen treten gehäuft bei Leistungssportlern, insbesondere bei Läufern auf. Obwohl Stressfrakturen bei Läufern im Bereich der unteren Extremität auftreten, sind sie auch, seltener, im Bereich des Beckens oder der unteren Wirbelsäule zu finden. Nicht selten kommt es bei unspezifischen Symptomen zu einer späten Diagnosestellung. Bei den meisten Patientinnen und Patienten mit sacralen Stressfrakturen handelt es sich um junge, körperlich aktive Patienten, meist Frauen. Wir stellen in diesem Bericht den Fall eines 31-jährigen, männlichen Langstreckenläufers vor, welcher sich inital mit persistierenden Schmerzen im Lumbal-, Sacral- und Gesäßbereich vorstellte. In den Wochen zuvor hatte er seine Trainingseinheiten gesteigert. Die Diagnose wurde letztlich mittels MRT des Beckens gestellt, woraufhin eine konservative Therapie eingeleitet wurde. Die Symptome sistierten nach 3 Monaten. Eine Verlaufskontrolle mittels MRT nach 6 Monaten konnte keine Residuen der Fraktur mehr darstellen.
Treatable Hereditary Manganese Transport Disorder: Novel SLC30A10 Mutation and its Characteristic Neuroimaging Appearance in Two Siblings
Authors: Santhakumar Senthilvelan , Lukas Jospaul , Unnikrishnan Gopikrishnan , Thomas Bejoy , Kesavadas Chandrasekharan 
Published: July 2020

AbstractHypermanganesemia with dystonia and polycythemia along with liver cirrhosis is a rare syndromic complex that is associated with a characteristic genetic mutation and a typical appearance in the T1-weighted noncontrast image. In this article, we reported the neuroimaging findings of two siblings affected by this syndrome. There are few reported cases in literature with similar findings. Diagnosing this problem will help in improving the outcomes as the condition is treatable. We reviewed the clinical and imaging findings of this condition and the differential diagnosis related to it.
Sequential Compression Device Adherence is Low in Hospitalized Antepartum Patients
Authors: Yamasato Kelly S. , Kurata Nicole B. , Harris Sara C. , Bartholomew Marguerite L. 
Published: July 2020

Objective This study was aimed to describe sequential compression device (SCD) adherence and its associations with SCD education in hospitalized antepartum women.
Study Design This study included antepartum, nonlaboring women admitted from 2016 to 2018, 1 year before and after an SCD education intervention. SCD use was assessed through the Kendall SCD 700 series compliance meter, which tracks the time the SCD machine takes within the monitoring interval. Recruitment occurred after 60 to 80 hours of monitoring, at which time a patient survey was completed. SCD use was the percentage of time the machine was on during monitoring. Mann–Whitney U and Chi-square tests were used to compare associations between SCD use, education, and pharmacologic prophylaxis.
Results Among 125 recruited women, 123 provided adherence data, 69 before and 54 after the education. Median SCD use was 17.3% before and 20.7% after (p = 0.71). Pharmacologic prophylaxis use was similar between the two periods and was not associated with SCD use. Among 121 surveys, the most common reason as to why SCDs were not worn was prevention of walking (52/121 [43.0%]).
Conclusion Using a novel monitoring technique, we found low-SCD use among antepartum inpatients, which was neither affected by education nor concurrent pharmacologic prophylaxis. Improving mobility with SCDs may improve use in this population.
Key Points
Fractal lattice as an efficient thermoelectric device
Authors: Chakraborty Suvendu , Maiti Santanu K. 
Published: July 2020

Abstract
Figure of merit is an essential quantity to describe the efficiency of a thermoelectric device and asymmetry in transmission probability is the main requirement to increase the efficiency. Keeping this fact in the mind, here we choose a Sierpinski Gasket (SPG) triangle, a nice example of fractal lattice, as the functional element since it has peculiar energy spectrum compared to the traditional elements. In the framework of tight binding (TB) model we calculate all the thermoelectric quantities using Landauer’s prescription. The atypical and strange behavior of transmission function can be further modified by incorporating asymmetry in the hopping integrals of the SPG network. Here, we acquire a remarkably large value of thermoelectric efficiency from the system and we strongly believe that our work can be verified by a suitable experimental setup. The present analysis can easily be generalized in other similar kind of fractal lattices having multiple loops.
High figure of merit in an ac driven graphene nanoribbon
Authors: Ganguly Sudin , Maiti Santanu K. 
Published: July 2020

Abstract
Generally, pristine graphene nanoribbons show poor thermoelectric (TE) performance. Several proposals are available to enhance the TE performance, which however requires some highly structural modifications of the system. In the present work, we explore a new prescription where a favorable TE response can be achieved by irradiating the ribbon. The electronic conductance, thermopower and thermal conductance due to electron are found to be highly sensitive to the irradiation. We obtain significantly enhanced thermopower along with highly suppressed thermal conductance for typical sets of irradiation parameters. As a result of this higher figure of merit is found. Therefore, we can suggest that a graphene nanoribbon can be used as an efficient energy conversion device in the presence of irradiation and hope that it will bear a significant impact in the energy market soon.
An improved approach to find the height of the accretion disk
Authors: Chatterjee Sangita , Mondal Soumen , Basu Prasad 
Published: July 2020

Abstract
In the present work, we propose an improved approach to find the height of the accretion disks around Kerr black holes. The vertical structure of the disk is obtained using a relativistic continuity equation and finally, the result is expressed in terms of the accretion rate and flow parameters. For different models of thin and slim disks, the expressions of the vertical height of the accretion disk are also been reviewed chronologically. We further discuss the basic assumptions, merits, and demerits of these models. Compared to existing approaches, our analysis is more self-consistent and less axiomatic. Further, we find that disk height is directly proportional to accretion rate which could be important to find out the vertical structure of the accretion disk in different black hole accretion states in a hysteresis cycle.
MRG: The Miscellaneous Radio Galaxies from the FIRST Survey
Authors: Bera Soumen , Pal Sabyasachi , Sasmal Tapan K. , Mondal Soumen , Patra Dusmanta 
Published: July 2020

Abstract
Miscellaneous Radio Galaxies (MRGs) are very rare kind of radio galaxies that exhibit unusual and different jet alignment and orientation from a typical radio galaxy. The peculiar and unique morphology of this type of radio source makes them a special case of study. In this paper, we report the identification of fifteen MRGs from VLA Faint Images of the Radio Sky at Twenty-Centimeters (VLA FIRST) Survey. The MRGs are identified manually by visual inspection of the FIRST database (December, 2017). The individual radio morphology of each sources are cross-checked at different frequencies from other surveys like TIFR GMRT Sky Survey at 150 MHz and Westerbork Northern Sky Survey at 325 MHz. We also identify the associated optical counterparts from the Sloan Digital Sky Survey (SDSS), where available. The different physical parameters like spectral index and radio luminosity of these MRGs are also estimated. An overview on the origin of these unique sources are also drawn.
Modelling and Simulation of Photo voltaic System Using Matlab/Simulink
Authors: Kumar Srivastav Amul , Kumar Gupta Abhishek , Raj Jaiswal Rishabh , Kumar Gupta Sarvesh 
Published: July 2020

Abstract
In regulate to optimize the effectiveness of the solar cell well established and more efficient models are required to develop. In this paper mathematical modelling of solar cell and an algorithm called Maximum Power Point Tracking (MPPT) has been studied. Matlab has been used for the simulation of mathematical modelling. I – V characteristics of the solar cell and MPPT algorithm is studied. The single diode model is used for mathematical modelling of the photovoltaic system. The required parameter for the system is taken from the datasheet of industrialized company. The solar cell highly dependent on the weather condition therefore I – V characteristics studied with the change in temperature and irradiation of the modelled system.
Aerial Cable Car in the City Centre of Makassar: The Potential Routes, Technology and Station Locations
Authors: Sutopo Y K D , Jinca M Y , Azmy M F , Maramis M V H , Amin M D 
Published: July 2020

Abstract
Aerial cable car is one of unique and efficient transportation modes that the world has today. This research aimed to explore the potential application of this mode in the urban areas of Makassar City, specifically in its city centre. It is designed to answer preliminary planning questions with regard to the best potential routes, technology, and station locations for the implementation of this mode in the near future. The research was conducted in 5 months (from April to August 2019). The data was collected through literature study and field survey including a traffic counting. The spatial analysis utilized satellite image map of Google Pro Earth, mapping, illustration and descriptive explanation. The research identified at least three trip purposes that the aerial cable car could potentially serve the city: for daily transportation, tourism, and shopping/business centres trips. It was concluded that trips to Lae-lae and Kayangan Resort Islands, the Losari City Tour, and trips from shopping mall to mall, are among potential routes that deserve for further comprehensive researches and feasibility studies. Monocable Detachable Gondola (MDG) is considered the best choice as a starting point in introducing this type of mode to the city and its people. The locational analysis based on defined criteria resulted five to nine potential station locations.
The Study of Public Open Space effectiveness in Makassar Waterfront City using Good Public Space Index (GPSI)
Authors: Ekawati S A , Ali M , Trisutomo S , Ghani R C A 
Published: July 2020

Abstract
Anjungan Pantai Losari is one of the famous public spaces in Makassar; it is a primary landmark in the city. Nevertheless, this public space is considered not optimal because it is only crowded with people’s activities in the afternoon and night. On the other hand, some theories argued that a good public open space has the ability to accommodate various people all day long. This study was conducted to evaluate and to study the effectiveness of public open space using the Good Public Space Index (GPSI). There are six variables used in GPSI: intensity use, the intensity of social use, people’s duration of stay, temporal diversity use, variety of use, and diversity of users. This study found that the average of GPSI value shows the high score of Anjungan Pantai Losari effectiveness. However, two variables, intensity of use and people duration of social use were still at a low level. It was expected that this research could be a reference to develop spatial planning, especially the improvement of public open space quality.
The Structure System of Bugis Traditional House in Disasters Perspective
Authors: Hartawan  , Sampebulu V , Junus N , Imriyanti  , Musharl P , Kuddu D , Alim I 
Published: July 2020

Abstract
The existence of traditional house until now could be believed as proof of a good human protector. Bugis traditional house is one of them. The research problem is how Bugis behavior and building structure performance to struggle in flood. The goal is to reveal the performance of house structure and Bugis ancestor behavior to survive after disasters. The methods are logical argumentation to explain the architectural knowledge, and modeling simulation to explain building structural performance. The results are Bugis ancestor has been leave inheritance a good behavior in survive after disasters through they architectural space arrangement. They prepare space in a safe area at their house for food storage, so when disasters happen they still have food stock without waiting for aids. The structure system as the stilt house its find in safe for the occupant because of space for human living lifted more than two meters above the ground surface. The structural performance indicates the displacement in early dangerous occur when flood loads higher than human living space. The best knowledge can be adopted in this research is the availability of food stock at own house. The better construction method to apply in flood area is the stilt house.