bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unmet Spiritual Care Needs in Women Undergoing Core Needle Breast Biopsy
Authors: Van Denburg Alyssa N , Shelby Rebecca A , Winger Joseph G , Zhang Lei , Soo Adrianne E , Pearce Michelle J , Soo Mary Scott 
Published: January 2020

Abstract

Objective
Spiritual care is an important part of healthcare, especially when patients face a possible diagnosis of a life-threatening disease. This study examined the extent to which women undergoing core-needle breast biopsy desired spiritual support and the degree to which women received the support they desired.

Methods
Participants (N = 79) were women age 21 and older, who completed an ultrasound- or stereotactic-guided core-needle breast biopsy. Participants completed measures of spiritual needs and spiritual care. Medical and sociodemographic information were also collected. Independent sample t-tests and chi-square tests of examined differences based on demographic, medical, and biopsy-related variables.

Results
Forty-eight participants (48/79; 60.8%) desired some degree of spiritual care during their breast biopsy, and 33 participants (33/78; 42.3%) wanted their healthcare team to address their spiritual needs. African American women were significantly more likely to desire some type of spiritual support compared to women who were not African American. Among the 79 participants, 16 (20.3%) reported a discrepancy between desired and received spiritual support. A significant association between discrepancies and biopsy results was found, χ 2(1) = 4.19, P = .04, such that 2 (7.4%) of 27 participants with results requiring surgery reported discrepancies, while 14 (26.9%) of 52 participants with a benign result reported discrepancies.

Conclusion
Most women undergoing core-needle breast biopsy desired some degree of spiritual care. Although most reported that their spiritual needs were addressed, a subset of women received less care than desired. Our results suggest that healthcare providers should be aware of patients’ desires for spiritual support, particularly among those with benign results.
A local solution approach for level-set based structural topology optimization in isogeometric analysis
Authors: Wu Zijun , Wang Shuting , Xiao Renbin , Yu Lianqing 
Published: January 2020

Abstract
This paper develops a new topology optimization approach for minimal compliance problems based on the parameterized level set method in isogeometric analysis. Here, we choose the basis functions as level set functions. The design variables are obtained with Greville abscissae based on the corresponding collocation points. The zero-level set boundaries are derived from the level set function values of the interpolation points in all knot spans. In the optimization iteration process, the whole design domain is discretized into two types of subdomains around the zero-level set boundaries, undesign area with void materials and redesign domain with solid materials. To decrease the size of equations and the computational consumptions, only the solid material area is recalculated and the void material area is discarded according to the high accuracy of isogeometric analysis. Numerical examples demonstrate the validity of the proposed optimization method.
Thermophoresis and suction/injection roles on free convective MHD flow of Ag–kerosene oil nanofluid
Authors: Upreti Himanshu , Pandey Alok Kumar , Kumar Manoj 
Published: January 2020

Abstract
In this article, the mass and heat transfer flow of Ag–kerosene oil nanofluid over a cone under the effects of suction/injection, magnetic field, thermophoresis, Brownian diffusion, and Ohmic-viscous dissipation was examined. On applying the suitable transformation, PDEs directing the flow of nanofluid were molded to dimensionless ODEs. The solution of the reduced boundary value problem was accomplished by applying Runge–Kutta–Fehlberg method via shooting scheme and the upshots were sketched and interpreted. The values of shear stress and coefficients of heat and mass transfer were attained for some selected values of governing factors. The obtained results showed that when the amount of surface mass flux shifts from injection to the suction domain, the heat and mass transfer rate grew uniformly. However, they have regularly condensed with the rise in the magnitude of the magnetic field and particle volume fraction. Several researches have been done using cone-shaped geometry under the influence of various factors affecting the fluid flow, yet, there exists no such investigation that incorporated the response of viscous-Ohmic dissipation, heat absorption/generation, suction/blowing, Brownian diffusion, and thermophoresis on the hydro-magnetic flow of silver-kerosene oil nanofluid over a cone.
TOI-132 b: A short-period planet in the Neptune desert transiting a V = 11.3 G-type star★
Authors: Díaz Matías R , Jenkins James S , Gandolfi Davide , Lopez Eric D , Soto Maritza G , Cortés-Zuleta Pía , Berdiñas Zaira M , Stassun Keivan G , Collins Karen A , Vines José I , Ziegler Carl , Fridlund Malcom , Jensen Eric L N , Murgas Felipe , Santerne Alexandre , Wilson Paul A , Esposito Massimiliano , Hatzes Artie P , Johnson Marshall C , Lam Kristine W F , Livingston John H , Van Eylen Vincent , Narita Norio , Briceño Cesar , Collins Kevin I , Csizmadia Szilárd , Fausnaugh Michael , Gan Tianjun , García Rafael A , Georgieva Iska , Glidden Ana , González-Cuesta Lucía , Jenkins Jon M , Latham David W , Law Nicholas M , Mann Andrew W , Mathur Savita , Mireles Ismael , Morris Robert , Pallé Enric , Persson Carina M , Ricker George , Rinehart Stephen , Rose Mark E , Seager Sara , Smith Jeffrey C , Tan Thiam-Guan , Tokovinin Andrei , Vanderburg Andrew , Vanderspek Roland , Winn Joshua N , Yahalomi Daniel A 
Published: January 2020

ABSTRACT
The Neptune desert is a feature seen in the radius-period plane, whereby a notable dearth of short period, Neptune-like planets is found. Here, we report the Transiting Exoplanet Survey Satellite (TESS) discovery of a new short-period planet in the Neptune desert, orbiting the G-type dwarf TYC 8003-1117-1 (TOI-132). TESS photometry shows transit-like dips at the level of ∼1400 ppm occurring every ∼2.11 d. High-precision radial velocity follow-up with High Accuracy Radial Velocity Planet Searcher confirmed the planetary nature of the transit signal and provided a semi-amplitude radial velocity variation of 11.38 $^{+0.84}_{-0.85}$ m s−1, which, when combined with the stellar mass of 0.97 ± 0.06 M⊙, provides a planetary mass of 22.40$^{+1.90}_{-1.92}$ M⊕. Modelling the TESS light curve returns a planet radius of 3.42$^{+0.13}_{-0.14}$ R⊕, and therefore the planet bulk density is found to be 3.08$^{+0.44}_{-0.46}$ g cm−3. Planet structure models suggest that the bulk of the planet mass is in the form of a rocky core, with an atmospheric mass fraction of 4.3$^{+1.2}_{-2.3}$ per cent. TOI-132 b is a TESS Level 1 Science Requirement candidate, and therefore priority follow-up will allow the search for additional planets in the system, whilst helping to constrain low-mass planet formation and evolution models, particularly valuable for better understanding of the Neptune desert.
PRMT5-mediated histone arginine methylation antagonizes transcriptional repression by polycomb complex PRC2
Authors: Liu Fan , Xu Ye , Lu Xiaoqing , Hamard Pierre-Jacques , Karl Daniel L , Man Na , Mookhtiar Adnan K , Martinez Concepcion , Lossos Izidore S , Sun Jun , Nimer Stephen D 
Published: January 2020

Abstract
Protein arginine methyltransferase 5 (PRMT5) catalyzes the symmetric di-methylation of arginine residues in histones H3 and H4, marks that are generally associated with transcriptional repression. However, we found that PRMT5 inhibition or depletion led to more genes being downregulated than upregulated, indicating that PRMT5 can also act as a transcriptional activator. Indeed, the global level of histone H3K27me3 increases in PRMT5 deficient cells. Although PRMT5 does not directly affect PRC2 enzymatic activity, methylation of histone H3 by PRMT5 abrogates its subsequent methylation by PRC2. Treating AML cells with an EZH2 inhibitor partially restored the expression of approximately 50% of the genes that are initially downregulated by PRMT5 inhibition, suggesting that the increased H3K27me3 could directly or indirectly contribute to the transcription repression of these genes. Indeed, ChIP-sequencing analysis confirmed an increase in the H3K27me3 level at the promoter region of a quarter of these genes in PRMT5-inhibited cells. Interestingly, the anti-proliferative effect of PRMT5 inhibition was also partially rescued by treatment with an EZH2 inhibitor in several leukemia cell lines. Thus, PRMT5-mediated crosstalk between histone marks contributes to its functional effects.
Structural basis of the zinc-induced cytoplasmic aggregation of the RNA-binding protein SFPQ
Authors: Huang Jie , Ringuet Mitchell , Whitten Andrew E , Caria Sofia , Lim Yee Wa , Badhan Rahul , Anggono Victor , Lee Mihwa 
Published: January 2020

AbstractSFPQ is a ubiquitous nuclear RNA-binding protein implicated in many aspects of RNA biogenesis. Importantly, nuclear depletion and cytoplasmic accumulation of SFPQ has been linked to neuropathological conditions such as Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). Here, we describe a molecular mechanism by which SFPQ is mislocalized to the cytoplasm. We report an unexpected discovery of the infinite polymerization of SFPQ that is induced by zinc binding to the protein. The crystal structure of human SFPQ in complex with zinc at 1.94 Å resolution reveals intermolecular interactions between SFPQ molecules that are mediated by zinc. As anticipated from the crystal structure, the application of zinc to primary cortical neurons induced the cytoplasmic accumulation and aggregation of SFPQ. Mutagenesis of the three zinc-coordinating histidine residues resulted in a significant reduction in the zinc-binding affinity of SFPQ in solution and the zinc-induced cytoplasmic aggregation of SFPQ in cultured neurons. Taken together, we propose that dysregulation of zinc availability and/or localization in neuronal cells may represent a mechanism for the imbalance in the nucleocytoplasmic distribution of SFPQ, which is an emerging hallmark of neurodegenerative diseases including AD and ALS.
Incentivizing Antibiotic Development: Why Isn’t the Generating Antibiotic Incentives Now (GAIN) Act Working?
Authors: Darrow Jonathan J , Kesselheim Aaron S 
Published: January 2020

Abstract
Antimicrobial resistance is of increasing global concern. To incentivize the creation of new treatments, the US Congress enacted the Generating Antibiotic Incentives Now Act (GAIN Act) of 2012, which provides benefits to manufacturers of Qualified Infectious Disease Products (QIDPs) including 5 years of additional nonpatent exclusivity. The results of this program have so far been disappointing, largely because QIDP eligibility criteria were not sufficiently targeted to unmet need. The time value of money also means that QIDP exclusivity disproportionately rewards modifications to existing drugs rather than the creation of new drugs. To improve the outlook, GAIN Act criteria should be limited to a more narrowly tailored list of qualifying pathogens to ensure that QIDPs offer clinical value not available from existing treatments. Additional options for improvement include greater reliance on animal data when determining QIDP eligibility and conditioning GAIN Act benefits on the availability of companion diagnostics.
Violence and the Chemicals Industry: Reframing Regulatory Obstructionism
Authors: Aho Brett 
Published: January 2020

AbstractWhen government actors seek to restrict the sale of hazardous substances, industry actors tend to intervene, deploying coordinated strategies aimed at delaying, preventing or weakening attempts to regulate their products. In many cases, this has involved deliberate efforts to obfuscate science, mislead the public and manipulate political actors in order to ensure desired policy outcomes. Strategies of regulatory obstructionism have resulted in the prolonged dispersal of harmful chemical substances with tangible impacts on public health. This article proposes that this behavior should be interpreted as a form of violence. Examining the regulatory histories of lead, benzene, asbestos and PCBs, the article demonstrates how regulatory obstructionism and violence have become intractable characteristics of the chemical industry.
Age-Conditional Effects of Political Skill and Empathy on Emotional Labor: An Experience Sampling Study
Authors: Toomey Eileen C , Rudolph Cort W , Zacher Hannes 
Published: January 2020

AbstractGrounded in lifespan development theories that posit a positive influence of aging on emotion regulation, we examine how chronological age and political skill (i.e., a work-related interpersonal competency that functions as an emotion-relevant resource) jointly moderate the relationships between within-person levels of empathy and the use of emotional labor strategies across a workweek. Participants were n = 118 full-time university employees (Mage = 42.85 years; SD = 12.18; range = 20–70), who completed momentary surveys 3 times a day, over a single 5-day workweek. Results show that age and within-person levels of empathy were positively related to momentary levels of deep acting. Considering further the interaction of age, political skill, and empathy, results suggest that the positive relationship between empathy and deep acting is conditional upon age and individual differences in political skill, with differential relationships observed for relatively older versus relatively younger participants. Overall, the findings of this study contribute to a better understanding of the role of age and political skill for daily emotional regulation in the work context.
Using ultrasound to diagnose long bone fractures
Authors: O'Brien Alexandra J. , Moussa Mohamad A. 
Published: January 2020

ABSTRACT
Point-of-care ultrasound may be an alternative to radiographs for diagnosing long bone fractures when medical resources are limited. Safe and timesaving, ultrasound also can be used in the ED as a screening tool for suspected long bone fractures and can detect associated musculoskeletal injuries. Ultrasound can be used in radiation-sensitive patients such as children and pregnant patients.
Studies have found that clinicians using ultrasound can detect long bone fractures with an average 90% sensitivity and specificity after an average of 1 to 4 hours total of didactic and practical training. More research is needed to determine standards for ultrasound training, patient morbidity outcomes, cost effectiveness, and insurance benefits.
Use of Palliative Care Consultation Services for Infants With Life-Threatening Conditions in a Metropolitan Hospital
Authors: McLaughlin S. Nicole , Song Mi-Kyung , Hertzberg Vicki , Piazza Anthony J. 
Published: January 2020

Background:
Palliative care is becoming an important component for infants with life-limiting or life-threatening conditions and their families. Yet palliative care practices appear to be inconsistent and sporadically used for infants.

Purpose:
The purpose of this study was to describe the use of an established pediatric palliative care team for seriously ill infants in a metropolitan hospital.

Methods:
This was a retrospective medical record review.

Findings:
The population included 64 infants who were admitted to a level IV neonatal intensive care unit (NICU) and then died during hospitalization between January 2015 and December 2016. Most infants died in an ICU (n = 63, 95%), and only 20 infants (31%) received palliative care consultation. Most common reasons for consultation were care coordination, defining goals of care and end-of-life planning, and symptom management.

Implications for Practice:
Palliative care consultation at this institution did not change the course of end-of-life care. Interventions provided by the ICU team to infants surrounding end of life were similar to those in infants receiving palliative care services from the specialists. Our findings may be useful for developing guidelines regarding how to best utilize palliative care services for infants with life-threatening conditions who are admitted to an ICU.

Implications for Research:
These finding support continued research in neonatal palliative care, more specifically the impact of palliative care guidelines and algorithms.
Practical Direct Immunofluorescence
Authors: Kim Randie H. , Brinster Nooshin K. 
Published: January 2020

Abstract:
Direct immunofluorescence (DIF) remains a valuable tool that may be underused because of perceived challenges in the interpretation, limitations, and processing of DIF specimens. The aim of this review is to provide a practical guide for appropriately incorporating DIF in a variety of clinical diseases, such as autoimmune blistering disorders. In vasculitis, the role of DIF continues to evolve, particularly in the setting of IgA vasculitis. Although typically not indicated for the workup of connective tissue disease, DIF may be helpful in cases with negative serologies, nondiagnostic histologic findings, or scarring alopecia. Practical pearls for biopsy technique, specimen handling, and storage are also discussed.
Contact Lenses and Infectious Keratitis: From a Case-Control Study to a Computation of the Risk for Wearers
Authors: Sauer Arnaud , Greth Mathieu , Letsch Jonathan , Becmeur Pierre-Henri , Borderie Vincent , Daien Vincent , Bron Alain , Creuzot-Garcher Catherine , Kodjikian Laurent , Burillon Carole , Robert Pierre-Yves , Mouriaux Frédéric , Muraine Marc , Gueudry Julie , Malecaze Francois , Cochener Béatrice , Chiquet Christophe , Labetoulle Marc , Bourcier Tristan 
Published: January 2020

Purpose:
Contact lens (CL)-related microbial keratitis (MK) has major public health implications, with about 300 million wearers worldwide, and certain potentially modifiable risk factors. This study aimed to identify the risk factors of CL-related MK.

Methods:
A multicenter case-control study was conducted between 2014 and 2017. Cases presenting with CL-related MK were submitted to an anonymous 52-item questionnaire, which was also completed by healthy controls. Univariate followed by multivariate logistic regression analysis was performed. Risk factors for CL-related MK were given as odds ratio (OR) with 95% confidence interval and P-value.

Results:
The study included a total of 2267 patients (1198 cases and 1069 controls). The MK risk factors for the daily disposable lenses group were exceeding the lens renewal period (OR = 9.16, P = 0.008) and occasionally wearing CL when sleeping (OR = 15.83, P = 0.035). The most important risk factors in the nondaily disposable lenses group were lens cleaning solution distributed by eye care brands (OR = 3.50, P < 0.001) and failure to renew lens cases (OR = 3.39, P = 0.001). Statistically and clinically significant variables were used to establish the MK risk equation for CL wearers, allowing an individual calculation of the risk of MK under lenses.

Conclusions:
The MK risk equation is a valuable tool for educating patients about the risks associated with wearing CL. It allows the patient to be informed about their overall risk of infection while detailing the precipitating elements of the infectious risk with the aim of modifying risk behavior.
Orbscan 3 Versus Pentacam HR: Evaluating the Possible Interchangeable Use of Various Parameters
Authors: Gharieb Hesham Mohamed , Othman Ihab Saad , Elkitkat Rania Serag 
Published: January 2020

Purpose:Many topography/tomography devices are available, and their interchangeable use is frequently questioned. This study aimed to compare the analogous indices of Orbscan 3 and Pentacam HR to detect whether the interchangeable use of the 2 devices is feasible.Methods:This retrospective study was conducted at Eye World Hospital, Giza, Egypt. Displays of Orbscan 3 (Bausch & Lomb; Technolas Perfect Vision GmbH) and Pentacam HR (Oculus Optikegrate) for 660 healthy right eyes were explored for various analogous indices. Bland–Altman plots with 95% limits of agreement (LoA) were used for comparisons.Results:The highest systematic error and lowest agreement existed in the front and back elevations from the best fit sphere (mean differences of 4.7 and 9.2 μm, respectively, and 95% LoA of −2.5 to 12.0 and −10.0 to 28.6, respectively). There was a relatively wide 95% LoA for each pachymetry at the corneal apex (−18 to 22 μm) and at the thinnest location (−22 to 22 μm), anterior chamber depth (−0.88 to 0.95 mm), flattest keratometry (−0.44 to 0.62 D), and steepest keratometry (−0.71 to 0.89 D). By contrast, the lowest systematic error and highest agreement existed for front and back best fit sphere radii of curvature (mean difference of 0.08 mm and 95% LoA of −0.08 to 0.24 and mean difference of 0.03 mm and 95% LoA of −0.17 to 0.23, respectively).Conclusions:This study negates the accuracy of the use of devices interchangeably regarding most parameters. Therefore, examinations with the 2 devices should not be regarded comparable.
Solitary Fibrous Tumors of the Lacrimal Drainage System With Variable Orbital and Sinonasal Extensions: Combined External and Endoscopic Surgical Approach
Authors: Morawala Ashi , Bothra Nandini , Dendukuri Gautam , Ali Mohammad Javed 
Published: January 2020

Purpose:
To report techniques and outcomes of a combined external and endoscopic surgical approach in the management of solitary fibrous tumors of the lacrimal drainage system with variable orbital and sinonasal extensions.

Methods:
Biopsy proven cases of solitary fibrous tumors of the lacrimal drainage system involving the lacrimal sac and the nasolacrimal ducts with an orbital, sinonasal, or intranasal extension were studied. Parameters assessed include patient demographics, clinical presentation and course, operative techniques, complications, postoperative adjuvant therapies and outcomes.

Results:
The technique is described in 3 patients. Two patients had massive orbital extension and one had gross sinonasal extension. Nasolacrimal duct extension was involved in all the patients with intranasal extension in 2 patients. External approach was used to access the lacrimal sac and the orbital components while the endoscopic approach was used to assess the orbital clearance and manage the sinonasal extension and the nasolacrimal duct excision up to the inferior meatus. Following complete excision, additional biopsies were performed from the adjacent bones and sinonasal tissues. A detailed histopathology with immunohistochemistry is essential for not only the diagnosis but also to assess the margin clearance. There were no major postoperative complications. All the patients were advised for postoperative adjuvant external beam radiotherapy. At the last follow-up, none of the patients had any clinical or endoscopic evidence of a recurrence.

Conclusions:
A combined external and endoscopic approach en-block excision is most suitable management modality for solitary fibrous tumors involving the lacrimal sac and the nasolacrimal ducts with orbital and sinonasal extension.