bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Use of Dual Mobility Implants in Patients Who Are at High Risk for Dislocation After Primary Total Hip Arthroplasty
Authors: Young Joseph R. , O’Connor Casey M. , Anoushiravani Afshin A. , DiCaprio Matthew R. 
Published: August 2020

Update
This article was updated on December 22, 2020, because of a previous error. On page 3, in Figure 2, the implant that was labeled “Polarcup™ Smith & Nephew” now reads “OR30 Dual Mobility System™ Smith & Nephew.”
An erratum has been published: JBJS Reviews. 2020 Dec;8(12):e20.00028ER.

» Dislocation after total hip arthroplasty (THA) is the leading cause of revision surgery. Dual mobility (DM) implants have been utilized over the past 40 years as a means of addressing and preventing this morbid and expensive complication. Recently, there has been renewed investigation into the role that DM implants may play in reducing instability in high-risk patients.» Hemiarthroplasty or traditional THA remain the mainstays of treatment for older patients with displaced femoral neck fractures. Longer-term higher-quality studies are necessary to investigate whether DM THA outcomes may be superior to traditional THA in the physiologically young patient with high physical demands and a longer-than-average life expectancy.» The use of DM implants in preventing dislocation in patients with fixed spinopelvic alignment, neuromuscular disorders, and failed fixation of previously sustained proximal femoral fractures has shown success in studies with low levels of evidence. More robust prospective data are necessary before more widespread adoption of DM arthroplasty is recommended in these clinical scenarios.» Knowledge of the pertinent literature with regard to the use of DM implants in patients who are at high risk for instability will allow orthopaedic surgeons to make informed decisions as to whether or not their patients may benefit from primary THA utilizing DM implants.
RNA-seq analysis of galaninergic neurons from ventrolateral preoptic nucleus identifies expression changes between sleep and wake
Authors: Guo Xiaofeng , Gao Xiaoling , Keenan Brendan T. , Zhu Jingxu , Sarantopoulou Dimitra , Lian Jie , Galante Raymond J. , Grant Gregory R. , Pack Allan I. 
Published: August 2020

Abstract
Background: Previous studies show that galanin neurons in ventrolateral preoptic nucleus (VLPO-Gal) are essential for sleep regulation. Here, we explored the transcriptional regulation of the VLPO-Gal neurons in sleep by comparing their transcriptional responses between sleeping mice and those kept awake, sacrificed at the same diurnal time. Results: RNA-sequencing (RNA-seq) analysis was performed on eGFP(+) galanin neurons isolated using laser captured microdissection (LCM) from VLPO. Expression of Gal was assessed in our LCM eGFP(+) neurons via real time qPCR and showed marked enrichment when compared to LCM eGFP(-) cells and to bulk VLPO samples. Gene set enrichment analysis utilizing data from a recent single-cell RNA-seq study of the preoptic area demonstrated that our VLPO-Gal samples were highly enriched with galanin-expressing inhibitory neurons, but not galanin-expressing excitatory neurons. A total of 263 genes were differentially expressed between sleep and wake in VLPO-Gal neurons. When comparing differentially expressed genes in VLPO-Gal neurons to differentially expressed genes in a wake-active neuronal region (the medial prefrontal cortex), evidence indicates that both systemic and cell-specific mechanisms contribute to the transcriptional regulation in VLPO-Gal neurons. In both wake-active and sleep-active neurons, ER stress pathways are activated by wake and cold-inducible RNA-binding proteins are activated by sleep. In contrast, expression of DNA repair genes is increased in VLPO-Gal during wakefulness, but increased in wake-active cells during sleep. Conclusion: Our study identified transcriptomic responses of the galanin neurons in the ventrolateral preoptic nucleus during sleep and sleep deprivation. Data indicate that VLPO contains mainly sleep-active inhibitory galaninergic neurons. The VLPO galanin neurons show responses to sleep and wake similar to wake-active regions, indicating these responses, such as ER stress and cold-inducible RNA-binding proteins, are systemic affecting all neuronal populations. Region-specific differences in sleep/wake responses were also identified, in particular DNA repair. Our study expands knowledge about the transcriptional response of a distinct group of neurons essential for sleep.
Associations between breastfeeding and cognitive function in children from early childhood to school age: a prospective birth cohort study
Authors: Kim Min Kyoung , Choi Jae-Won 
Published: August 2020

Abstract
Background:Despite evidences of breastfeeding for preventing acute physical illnesses in infants, the evidence for the association between breastfeeding and long-term cognitive development is not yet convincing.Methods:The data of nationwide representative sample of 1,752 children born between 2008 and 2009 in Korea were prospectively assessed from the fetal period to examine the benefits of breastfeeding and cognitive development. Breastfeeding duration was prospectively assessed by parents. The Korean Ages and Stages Questionnaire and the Korean version of Denver II were used to assess early development annually from 5.5 to 26.2 months of age. Language development at 3 years of age was assessed with Receptive and Expressive Vocabulary Tests. Cognitive function at 8 years of age was assessed using multifactorial intelligence test.Results:Children who were breastfed for 1–3 months displayed significantly higher odds ratios for delayed development assessed at 14.1 months than those breastfed for 3–6 months (OR = 2.21; 95% CI: 1.08, 4.50). Children who were breastfed for >3 months also scored significantly higher on the communication (F = 17.71; p < 0.001) and problem-solving (F = 11.26; p < 0.001) subscales at 14.1 months of age, and the expressive language subscale (F = 12.85; p < 0.001) at 3 years, compared to children breastfed for 3 months or less. The performances on the calculation subscale (F = 2.43; p = 0.033) at 8 years of age differed significantly among the groups of breastfeeding duration. Conclusion:We found that cognitive development was improved in children that were breastfed for >3 months. Although these results are supported by previous studies, it is important to note that other factors were reported as larger determinants of cognitive development than breastfeeding. Future studies that examine the underlying mechanism for the association between breastfeeding and cognitive development are warranted.
The annual cost of providing paid maternity leave in the informal sector in Indonesia&nbsp;
Authors: Siregar Adiatma , Pitriyan Pipit , Hardiawan Donny , Zambrano Paul , Vilar-Compte Mireya , Belismelis Graciela Ma Teruel , Moncada Meztli , Tamayo David , Carroll Grace , Perez-Escamilla Rafael , Marthisen Roger 
Published: August 2020

Abstract
BackgroundThe economic cost of not breastfeeding in Indonesia is estimated at US$1.5–9.4 billion annually, the highest in South East Asia. Half of the 33.6 million working women of reproductive age (WRA) in Indonesia (15-49 years) are informal employees, meaning they are working as casual workers or they are self-employed (small scale business) and assisted by unpaid/family worker(s). No specific maternity protection entitlements are currently available for WRA working informally in Indonesia. This study aims to estimate the cost of providing maternity leave cash transfer (MCT) for WRA working in the informal sector in Indonesia.MethodThe costing methodology used is the adapted version of the World Bank methodology by Vilar-Compte et al (2019), following pre-set steps to estimate costs using national secondary data. We used the 2018 Indonesian National Socio-Economic Survey to estimate the number of women working informally who gave birth within the last year. The population covered, potential cash transfer’s unitary cost, the incremental coverage of the policy in terms of time and coverage, and the administrative costs were used to estimate the cost of MCT for the informal sector. ResultAt 100% coverage for 13 weeks of leave, the annual cost of MCT ranged from US$175million (US$152/woman) to US$669million (US$583/woman). The share of the annual costs did not exceed 0.5% of Indonesian Gross Domestic Product (GDP).ConclusionThe yearly cost of providing MCT for eligible WRA working in the informal sector is economically attractive as it amounts to less than 0.5% of GDP nominal of Indonesia. While such a program would be perceived as a marked increase from current public health spending at the onset, such an investment could substantially contribute to the success of breastfeeding and substantial corresponding public health savings given that more than half of working Indonesian WRA are employed in the informal sector. Such policies should be further explored while taking into consideration realistic budget constraints and implementation capacity.
Cessation of breastfeeding and associated factors in the era of elimination of mother to child transmission of HIV at Ndejje Health Center, Uganda: a retrospective cohort study
Authors: Ngbapai Jackslina Gaaniri , Izudi Jonathan , Okoboi Stephen 
Published: August 2020

Abstract
BackgroundBreastfeeding an infant exposed to Human Immunodeficiency Virus (HIV) carries the risk of HIV acquisition whilst not breastfeeding poses a higher risk of death from malnutrition, diarrhea, and pneumonia. In Uganda, mothers living with HIV are encouraged to discontinue breastfeeding at 12 months but data are limited. We examined the frequency and factors associated with cessation of breastfeeding at one year among mothers living with HIV at Ndejje Health Center IV, a large peri-urban health facility in Uganda.MethodsThis retrospective cohort study involved all mothers living with HIV and enrolled in HIV care for ≥ 12 months between June 2014 and June 2018. We abstracted data from registers, held focus group discussions with mothers living with HIV and key informant interviews with healthcare providers. Cessation of breastfeeding was defined as the proportion of mothers living with HIV who had discontinued breastfeeding at one year. We summarized quantitative data descriptively, tested differences in outcome using Chi-square and t - tests, and established independently associated factors using modified Poisson regression analysis at 5 % statistical significance level. We thematically analyzed qualitative data to enrich and triangulate the quantitative results. ResultsOf 235 participants, 150 (63.8 %) had ceased breastfeeding at one year and this was independently associated with the infant being male (Adjusted Risk Ratio [aRR] 1.25, 95 % confidence interval [CI] 1.04, 1.50), the mother being multiparous (aRR 1.26, 95 % CI 1.04-1.53), and the initiation of breastfeeding being on the same-day as birth (aRR 0.06, 95 % CI 0.01-0.41). The reasons for ceasing breastfeeding included male infants over breastfeed than females, maternal literacy and knowledge adequacy about breastfeeding, support and reminders from the partner, and boys can bite once they get teeth. ConclusionSuboptimal proportion of infants were ceased from breastfeeding at one year and this might increase the risk of mother to child transmission of HIV. Cessation of breastfeeding was more likely among male infants and multiparous mothers but less likely when breastfeeding was initiated on the same-day as birth. Interventions to enhance cessation of breastfeeding should target none multiparous mothers and those with female infants.
Do the dynamics of vaccine programs improve the full immunization of children under the age of five in Cameroon?
Authors: DEFFO Rodrigue NDA'CHI , KAMGA Benjamin FOMBA 
Published: August 2020

Abstract
Background: Among the eight Millennium Development Goals (MDGs), three were devoted to health. Two amongst which MDG4 in relation to the reduction of infant mortality has not been achieved in Least Developed Countries (LDC). In Africa, a significant part of infant mortality is due to vaccine-preventable diseases administered free of charge by the Extended Program on Immunization (EPI). As such, in the "social equity" pillar of Sustainable Development Goals (SDG), the MDGs related to health have yet been taken into account. The achievement of these objectives requires an understanding of the immunization behavior of children under five years of age through an analysis of immunization dynamics between 1991 and 2011.Methods: We use data from Demographic and Health Surveys (DHS) of 1991, 1998, 2004 and 2011 carried out by the National Institute of Statistics (NIS). The module concerning EPI vaccines was administered to 3350, 2317, 8125 and 25524 under 5 in 1991, 1998, 2004 and 2011 respectively. The Immunization analysis was made from the logistic model for complete immunization and the Oaxaca's decomposition to assess the contribution of the unexplained part, which is that of the strategies/programs implemented between 1991 and 2011 by the EPI to improve immunization.Results: In general, children with vaccination card are more than 7 times likely to be fully immunized than their counterparts who do not have any. This result was higher in 1991 (approximately 57) and lowest in 2011 (5). In addition, the child's birth order reduces his/her probability of being fully immunized and the impact increases with the latter's birth order. On the other hand, the mother's age as well as her level of education increase the child's likelihood of receiving all basic vaccines. Moreover, the contributions of EPI partners in terms of immunization support as well as strategies to promote immunization through communication for development are of a particular importance in increasing immunization coverage. They significantly explain 67.62% of the 0.105 gain recorded within the 2011-2004 period and 72.46% of the 0.069 gain recorded within the 2004-1998 period.Conclusion: The contribution of EPI partner organizations is fundamental for the achievement of EPI objectives. Since they contribute to increase the likelihood of fully immunized children. The link with child immunization is done through the specific characteristics to the mother.
Effect of Maternal Sleep, Physical Activity and Screen Time during Pregnancy on the Risk of Childhood Respiratory Allergies: a Sex-specific Study
Authors: Chen Yiting , Lyu Jiajun , Xia Yuanqing , Zhu Jianzhen , Tong Shilu , Yin Yong , Qu Jiajie , Li Shenghui 
Published: August 2020

Abstract
Background: Early life exposure in the uterus had a long-term effect on children's health. As the prevalence of allergies is increasing with a remarkable sex difference, very few studies have traced back to their early origins. We sought to investigate if maternal behavioral exposure, herein sleep, physical activity, and screen time during pregnancy is associated with childhood respiratory allergies. The sex difference would be examined. Methods: 6236 mother-child pairs from Shanghai Children Allergy Study (SCAS) were enrolled, The International Study of Asthma and Allergies in Childhood questionnaire was adopted to evaluate respiratory allergic diseases. Results: 14.6%, 16.2%, and 21.0% of children had asthma, wheeze, and allergic rhinitis, respectively. Maternal short sleep duration, lack of physical activity, and too much screen exposure during pregnancy could increase the risk of childhood respiratory allergies, however, the significance was found only in males. Moreover, a dose-response trend was clearly shown, any two of the three combined could increase the risk (OR,1.921; 95%CI,1.217-3.033), and the coexistence of all three further amplified the risk (OR,2.412; 95%CI,1.489-3.906). The findings can be verified in allergen test subgroup and each single type of respiratory allergies in most cases. Conclusions: Maternal unhealthy behaviors during pregnancy could increase the risk of childhood respiratory allergies with a dose-response pattern. Males were more susceptible to the association. The identification of modifiable maternal risk behaviors lies in the emphasis of intervention in early life to face up increasing childhood allergies.
Dust Emission Source Characterization for Visibility Hazard Assessment on Lordsburg Playa in Southwestern New Mexico, USA
Authors: Pelt Robert Scott Van , Tatarko John , Gill Thomas E. , Chang Chunping , Li Junran , Eibedingil Iyasu , Mendez Marcos 
Published: August 2020

Abstract
Ephemeral lakes (playas) at the termination of drainages are a common feature of drylands. When dry, playa sediments can be highly wind-erodible, becoming potent local and regional sources of dust and PM 10 , airborne particles with diameters less than 10 µm, causing potentially sudden loss of visibility to travelers on downwind roadways. Lordsburg Playa, in southwestern New Mexico, USA is bisected by Interstate Highway 10. Dust storms emanating from the playa have been responsible for numerous visibility-related road closures (including 39 road closures between 2012- 2019) causing major economic losses, as well as hundreds of dust-related vehicle crashes, causing 41 lost lives in the last 53 years. We investigated the critical wind friction velocity thresholds and the dust emissivities of surfaces representing areas typical of Lordsburg Playa’s stream deltas, shorelines, and ephemerally flooded lakebed using a Portable In-Situ Wind ERosion Laboratory (PI-SWERL). Mean threshold friction velocities for PM 10 entrainment ranged from less than 0.30 m s -1 for areas in the delta and shoreline to greater than 0.55 m s -1 for ephemerally flooded areas of the lakebed. Similarly, we quantified mean PM 10 vertical flux rates ranging from less than 500 µ g m -2 s -1 for ephemerally flooded areas of lakebed to nearly 25,000 µg m -2 s -1 for disturbed delta surfaces. The apparently unlimited PM 10 supply of the relatively coarse sediments along the western shoreline however is problematic and indicates that this may be the source area for longer-term visibility limiting dust events and should be a focus area for dust mitigation efforts.
Efficacy and safety of Jie-du-qing-nao granules for first-episode schizophrenics: study protocol for a randomized controlled trial
Authors: Li Ziyan , Ning Yanzhe , Chen Pei , Zhang Yi , Yin Dongqing , Zhu Hong , Liu Shanshan , Jia Hongxiao 
Published: August 2020

Abstract
BackgroundAt present, the focus and difficulty of schizophrenia (SCZ) treatment is to improve cognitive function and negative symptoms. Jie-du-qing-nao granules(JQG) , a traditional Chinese medicine(TCM) prescription , has a good clinical effectiveness in enhancing the cognition and negative symptoms of patients with SCZ. However, its clear effectiveness and safety have not been adequately supported by clinical studies. The main objective of this study is to explore the efficacy and safety of JQG for first-episode schizophrenics.Methods/designThis trial is a prospective, randomized, single-centered, parallel-controlled clinical study with double-blind design. A total of 96 eligible participants will be randomly assigned to either the study group or the control group in a ratio of 1:1. Participants allocated to the study group will receive JQG and aripiprazole, control group will receive placebo and aripiprazole. The treatment course will last 12 weeks, with follow-up every 4 weeks. Outcome measurements include Positive and Negative Syndrome Scale (PANSS), self face test , MATRICS Consensus Cognitive Battery (MCCB), TNFα, IL-6, IL-1β, BDNF, vital signs, complete blood count, liver and kidney function tests, urinalysis, and electrocardiograph. Adverse reactions will be evaluated using the Treatment Emergent Symptom Scale (TESS).DiscussionThis study will provide evidence for the efficacy and safety of JQG as a complementary approach, which can be initiated following with antipsychotics therapy. Trial registration Chinese Clinical Trial Registry, ID: ChiCTR1900028250 . Registered on December 16, 2019, http://www.chictr.org.cn/edit.aspx?pid=41880&htm=4 .
Delineation of molecular findings by whole exome sequencing for suspected cases of paediatric-onset mitochondrial diseases in the Southern Chinese population
Authors: Tsang Mandy Ho-Yin , Kwong Anna Ka-Yee , Chan Kate Lok-San , Fung Jasmine Lee-Fong , Yu Mullin Ho-Chung , Mak Christopher Chun-Yu , Yeung Kit-San , Rodenburg Richard J.T. , Smeitink Jam A.M. , Chan Rachel , Tsoi Thomas , Hui Joannie , Wong Sheila Suet-Na , Tai Shuk-Mui , Chan Victor Chi-Man , Ma Che-Kwan , Fung Tsiu-Hang Sharon , Wu Shun-Ping , Chan WK , Chung Brian Hon-Yin , Fung Cheuk-wing 
Published: August 2020

Abstract
BackgroundMitochondrial diseases (MDs) are a group of clinically and genetically heterogeneous disorders characterized by defects in oxidative phosphorylation. Since clinical phenotypes of MDs may be non-specific, genetic diagnosis is crucial for guiding disease management. In the current study, whole-exome sequencing (WES) was performed for our paediatric-onset MD cohort of a Southern Chinese origin, with the aim of identifying key disease-causing variants in the Chinese patients with MDs.MethodsWe recruited Chinese patients who had paediatric-onset MDs and a minimum mitochondrial disease criteria (MDC) score of 3. Patients with positive target gene or mitochondrial DNA sequencing results were excluded. WES was performed, variants with population frequency ≤1% were analysed for pathogenicity on the basis of the American College of Medical Genetics and Genomics guidelines.ResultsSixty-six patients with pre-biopsy MDC scores of 3–8 were recruited. The overall diagnostic yield was 35% (23/66). Eleven patients (17%) were found to have mutations in MD-related genes, with COQ4 having the highest mutation rate owing to the Chinese-specific founder mutation (4/66, 6%). Twelve patients (12/66, 18%) had mutations in non-MD-related genes: ATP1A3 (n=3, two were siblings), ALDH5A1 , ARX , FA2H , KCNT1 , LDHD , NEFL , NKX2-2 , TBCK , and WAC.ConclusionsWe confirmed that the COQ4 :c.370G>A, p.(Gly124Ser) variant was a recurrent founder mutation among the Southern Chinese population. Screening for this mutation should therefore be considered while diagnosing Chinese patients suspected to have MDs. Furthermore, WES has proven to be useful in detecting variants in patients suspected to have MDs because it helps to obtain an unbiased and precise genetic diagnosis for these diseases, which are genetically heterogeneous.