bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Socioeconomic Edge Effect: Rational Crime in Small Areas of Sharp Socioeconomic Contrast
Authors: Heinzeroth Robert Drew 
Published: August 2020

Objectives: To determine whether criminogenic “edges,” as defined by crime pattern theory, exist at points of sharp contrast of socioeconomic status (SES). Methods: The study uses a quasi-experimental design with pattern matching logic. A series of negative binomial regression models separately examine five different crimes with an economic incentive as dependent variables, and five crimes without an economic incentive as nonequivalent dependent variables, to determine whether census block groups of predominantly and comparatively higher SES than the wider surrounding area experience greater reported rational crime than would otherwise be expected. Results: The census block groups of comparatively higher SES located within and/or near areas of predominantly lower SES experienced one of the five crimes with an economic incentive, robberies by firearm, 40 percent more frequently than would otherwise be expected. Conclusions: The study’s findings are partially consistent with its hypothesis, which is grounded in crime pattern, rational choice, routine activities, and social disorganization theories. The findings encourage future research that may extend the definition of an “edge” under crime pattern theory as well as research at the intersection of criminological theories.
Acute isotonic hyponatremia after single dose histidine-tryptophan-ketoglutarate cardioplegia: an observational study
Authors: van Houte Joris , Bindels Alexander J , Houterman Saskia , Dong Phi Vu , den Ouden Monique , de Bock Nina E , Verberkmoes Niels J , Curvers Joyce , Bouwman Arthur R 
Published: August 2020

Introduction: Histidine-tryptophan-ketoglutarate cardioplegia is used for prolonged myocardial protection in complex cardiac surgery. Administration leads to acute hyponatremia in a majority of patients, because of its low sodium concentration (15 mmol/L). However, histidine-tryptophan-ketoglutarate solution’s osmolality is slightly hypertonic (310 mOsm/kg). Hypothesized was that acute isotonic hyponatremia will be induced, which does not need to be corrected with hypertonic saline. Methods: Cardiac surgery patients who received histidine-tryptophan-ketoglutarate cardioplegia were included in this prospective single center study. Serial blood samples were taken from each patient at five different time points: after induction of anesthesia (T1) and 10 minutes (T2), 6 hours (T3), 12 hours (T4), and 18 hours (T5) after administration of histidine-tryptophan-ketoglutarate cardioplegia, respectively. Blood samples were analyzed for sodium concentration, osmolality, and acid-base balance. Results: Twenty-five patients were included. Median blood sodium levels decreased from 140 [138-141] at T1 to 128 [125-130] mmol/L at T2 (p < 0.001). At T3, T4, and T5, median blood sodium concentrations were 136 [134-138], 139 [137-140], and 140 [137-142] mmol/L, respectively. Median osmolality was 289 [286-293] at T1 and increased to 296 [291-299] mOsm/kg (p < 0.001) at T2. At T3, T4, and T5, osmolality was 298 [292-302], 298 [294-304], and 300 [297-306] mOsm/kg, respectively. Median pH decreased from 7.38 [7.36-7.40] at T1 to 7.30 [7.27-7.32] at T2 (p < 0.001). Conclusion: Administration of histidine-tryptophan-ketoglutarate cardioplegia during cardiac surgery leads to acute moderate to severe isotonic hyponatremia, which resolves spontaneously in the first 18 hours perioperatively. Correction with hypertonic saline is not necessary.
Vertebral Fractures: Which Radiological Criteria Are Better Associated With the Clinical Course of Osteoporosis?
Authors: Lentle Brian C. , Berger Claudie , Brown Jacques P. , Probyn Linda , Langsetmo Lisa , Hammond Ian , Hu Jeff , Leslie William D. , Prior Jerilynn C. , Hanley David A. , Adachi Jonathan D. , Josse Robert G. , Cheung Angela M. , Kaiser Stephanie M. , Towheed Tanveer , Kovacs Christopher S. , Wong Andy Kin On , Goltzman David 
Published: August 2020

Study Purpose: Morphometric methods categorize potential osteoporotic vertebral fractures (OVF) on the basis of loss of vertebral height. A particular example is the widely used semiquantitative morphometric tool proposed by Genant (GSQ). A newer morphologic algorithm-based qualitative (mABQ) tool focuses on vertebral end-plate damage in recognizing OVF. We used data from both sexes in the Canadian Multicentre Osteoporosis Study (CaMos) to compare the 2 methods in identifying OVF at baseline and during 10 years of follow-up. Materials and Methods: We obtained lateral thoracic and lumbar spinal radiographs (T4-L4) 3 times, at 5-year intervals, in 828 participants of the population-based CaMos. Logistic regressions were used to study the association of 10-year changes in bone mineral density (BMD) with incident fractures. Results: At baseline, 161 participants had grade 1 and 32 had grade 2 GSQ OVF; over the next 10 years, only 9 of these participants had sustained incident GSQ OVF. Contrastingly, 21 participants at baseline had grade 1 and 48 grade 2 mABQ events; over the next 10 years, 79 subjects experienced incident grade 1 or grade 2 mABQ events. Thus, incident grades 1 and 2 morphologic fractures were 8 times more common than morphometric deformities alone. Each 10-year decrease of 0.01 g/cm2 in total hip BMD was associated with a 4.1% (95% CI: 0.7-7.3) higher odds of having an incident vertebral fracture. Conclusions: This analysis further suggests that morphometric deformities and morphologic fractures constitute distinct entities; morphologic fractures conform more closely to the expected epidemiology of OVF.
Human-environment interaction during the Holocene along the shoreline of the Ancient Lake Ladoga: A case study based on palaeoecological and archaeological material from the Karelian Isthmus, Russia
Authors: T Alenius , D Gerasimov , T Sapelko , A Ludikova , D Kuznetsov , A Golyeva , K Nordqvist 
Published: August 2020

This paper presents the results of pollen, diatom, charcoal, and sediment analyses from Lake Bol’shoye Zavetnoye, situated between the Gulf of Finland and Lake Ladoga on the Karelian Isthmus, north-western Russia. The main goal is to contribute to the discussion of Neolithic land use in north-eastern Europe. The article aims to answer questions related to Stone Age hunter-gatherer economy, ecology, and anthropogenic environmental impact through a comprehensive combination of multiple types of palaeoecological data and archaeological material. According to diatom data, Lake Bol’shoye Zavetnoye was influenced by the water level oscillations of Ancient Lake Ladoga during much of the Holocene. Intensified human activity and prolonged human occupation become visible in the Lake Bol’shoye Zavetnoye pollen data between 4480 BC and 3250 BC. During the final centuries of the Stone Age, a new phase of land use began, as several anthropogenic indicators, such as Triticum, Cannabis, and Plantago lanceolata appear in the pollen data and a decrease in Pinus values is recorded. In general, the results indicate that socio-cultural transformations could have taken place already from the mid-5th millennium BC onwards, including new ways of utilizing the environment, perhaps also in the field of subsistence, even though the livelihood was based on foraging throughout the period.
“APS pregnancy – The offspring”
Authors: Bitsadze Viktoria , Nalli Cecilia , Khizroeva Jamilya , Lini Daniele , Andreoli Laura , Lojacono Andrea , Fazzi Elisa , Shoenfeld Yehuda , Tincani Angela , Makatsariya Alexander 
Published: August 2020

Background Antiphospholipid antibody syndrome (APS) is an autoimmune disease that affects women in childbearing age. In recent years, great improvements were achieved in the management of pregnancies in these women. Prematurity could be an issue in these pregnancies, mainly due to the direct pathogenic effect of antiphospholipid antibodies (aPL) on the placental surface. Maternal IgG aPL can cross the placenta and theoretically interact with the growing fetus; it could reach the fetal brain because of the incompleteness of the fetal blood-brain barrier: whether this can have an effect on brain development is still debated. Neonatal thrombosis episodes have been described in children positive for aPL, not always associated with maternal antibody positivity, suggesting the hypothesis of a possible aPL de novo synthesis in fetus and neonates. Methods A keyword-based literature search was conducted. We also described a case of neonatal catastrophic antiphospholipid syndrome (CAPS). Results Offspring of patients with APS are generally healthy but the occurrence of neonatal thrombosis or minor neurological disorders were reported. Conclusions The limited number of the available data on this sensitive issue supports the need for further studies. Clinical follow-up of children of mothers with APS seems to be important to exclude, in the neonatal period, the occurrence of aPL associated pathological events such as thrombosis, and in the long-term, impairment in learning skills or behavioral problems.
Prospective Randomized Evaluation of Local Injection of Allogeneic Growth Factors in Plantar Fasciitis
Authors: Kandil Mahmoud Ibrahim , Tabl Eslam Abdelshafi , Elhammady Adel Samy 
Published: August 2020

Background: The aim of this study was to evaluate the efficacy and safety of injection of allogeneic growth factors in patients with plantar fasciitis. Methods: This study included 150 patients who were randomly divided into 2 equal groups; the patients were locally injected with allogeneic growth factors (GFs) (treatment group) or with saline 0.9% (control group). The patients were assessed using visual analog scale (VAS) and Foot Function Index–Revised short form (FFI-Rs) scores preinjection and 1, 3, 6, and 12 months postinjection. The patients were questioned about their satisfaction. Any adverse effects were recorded. Results: At baseline, there was no significant difference between both groups regarding the mean VAS and FFI-Rs scores. At 3-month follow-up, the reduction in mean VAS score was 87% in the treatment group and 55% in the control group ( P < .001), and the reduction in mean FFI-Rs score was 62% in the treatment group and 40% in the control group ( P < .001). Treatment group and study visit were significant factors affecting both VAS and FFI-Rs scores. Overall, 92% were satisfied in the treatment group, and 78.2% in the control group. Postinjection pain occurred in 5 patients in the treatment group. Conclusion: This study provides Level I evidence regarding the efficacy and safety of allogeneic GF injection in patients with plantar fasciitis. However, additional studies are needed to evaluate their adverse effects, immunogenicity, and microbiological safety. Level of Evidence: Level I, prospective randomized controlled case series.
The Effects of Noninvasive Traction on SSEPs During Ankle Arthroscopy
Authors: Altbuch Tristan , Ayzenberg Mark , Bloze A. Elizabeth , Ferkel Richard D. 
Published: August 2020

Background: The purpose of this study was to evaluate the effects of noninvasive ankle distraction on intraoperative somatosensory evoked potentials (SSEPs) and peripheral nerve sensibility of the foot during ankle arthroscopy. Methods: Twenty patients undergoing ankle arthroscopy were prospectively evaluated using noninvasive ankle traction. All had preoperative clinical examination with baseline neurologic evaluation and static 2-point discrimination (2PD) test. Intraoperative SSEPs were monitored continuously throughout surgery. Thirty pounds of traction was applied using noninvasive traction. A 50% decrease in amplitude or a 10% increase in latency was considered significant. At 2 weeks postoperatively, the 2PD test was repeated. Pre- and postoperative 2PD was compared and subsequently correlated with intraoperative SSEPs. Results: Three patients sustained significant SSEP signal alterations during surgery. The changes were transient and directly related to application of traction but returned to baseline without traction release. Abnormal postoperative 2PD testing was found in the operative extremity in 12 patients but resolved by the second postoperative visit. Only 2 of 12 had intraoperative SSEP changes. Eleven patients had abnormal postoperative 2PD testing in the nonoperative limb. Nine had changes in both limbs. Routine history and clinical examination did not suggest any neurologic injury. There was no statistically significant correlation between intraoperative SSEP alterations and subsequent development of abnormal postoperative 2PD testing. Conclusion: Transient intraoperative SSEP changes occurred with noninvasive distraction but were reversible when using 30 pounds of traction. 2PD testing changes were common postoperatively but not correlated to changes in SSEP. Patients with increased 2PD did not have sensory changes detectable on clinical exam or subjective patient history. Level of Evidence: Experimental level II, prospective comparative study.
Mind the gap: Comparing perspectives of service providers to the needs of people with dementia living in the community
Authors: Morrisby Claire , Ciccarelli Marina , Joosten Annette 
Published: August 2020

Introduction Research with West Australian people with dementia and their carers living in the community identified that they have a diverse range of needs. However, little is known about the needs of people with dementia and their carers from the perspectives of service providers who provide formal support. This study aimed to investigate the needs of people with dementia and their carers living in the community from the perspectives of service providers, and compare this to service recipients. Method This interpretive descriptive study used focus groups to collect qualitative data from service providers ( N = 10). Data were analysed using a hybrid inductive–deductive approach to compare the needs identified by service providers to those identified by people with dementia and their carers. Results Three major themes were identified: (i) services and supports required by people with dementia and their carers should be flexible, tailored, and equitable; (ii) building capacity to support carers and people with dementia; and (iii) systems designed to care were fragmented and difficult to navigate. Service providers prioritise needs that are limited to their current capacity to provide in contrast to the holistic needs of people with dementia and their carers. Conclusion There was poor alignment between the perceived needs of people with dementia and their carers and the needs prioritised by service providers in the West Australian community. This gap may reduce the ability of services to effectively support people with dementia to remain living in the community.
Addressing the quality of submissions to ClinicalTrials.gov for registration and results posting: The use of a checklist
Authors: Tetteh Oswald , Nuamah Prince , Keyes Anthony 
Published: August 2020

Background: US Federal regulations since the late 1990s have required registration of some clinical trials and submission of results for some of these trials on a public registry, ClinicalTrials.gov. The quality of the submissions made to ClinicalTrials.gov determines the duration of the Quality Control review, whether the submission will pass the review (success), and how many review cycles it will take for a study to be posted. Success rate for all results submitted to ClinicalTrials.gov is less than 25%. To increase the success of investigators’ submissions and meet the requirements of registration and submission of results in a timely fashion, the Johns Hopkins ClinicalTrials.gov Program implemented a policy to review all studies for quality before submission. To standardize our review for quality, minimize inter-reviewer variability, and have a tool for training new staff, we developed a checklist. Methods: The Program staff learned from major comments received from ClinicalTrials.gov and also reviewed the Protocol Registration and Results System review criteria for registration and results to fully understand how to prepare studies to pass Quality Control review. These were summarized into bulleted points and incorporated into a checklist used by Program staff to review studies before submission. Results: In the period before the introduction of the checklist, 107 studies were submitted for registration with a 45% (48/107) success rate, a mean (SD) of 18.9 (26.72) days in review, and 1.74 (0.78) submission cycles. Results for 44 records were submitted with 11% (5/44) success rate, 115.80 (129.33) days in review, and 2.23 (0.68) submission cycles. In the period after the checklist, 104 studies were submitted for registration with 80% (83/104) success rate, 2.12 (3.85) days in review, and 1.22 (0.46) submission cycles. Results for 22 records were submitted with 41% (9/22) success rate, 39.27 (19.84) days in review, and 1.64 (0.58) submission cycles. Of the 44 results submitted prior to the checklist, 30 were Applicable or Probable Applicable Clinical Trials, with 10% (3/30) being posted within 30 days as required of the National Institutes of Health. For the 22 results submitted after the checklist, 17 were Applicable or Probable Applicable Clinical Trials, with 47% (8/17) being posted within 30 days of submission. These pre- and post-checklist differences were statistically significant improvements. Conclusion: The checklist has substantially improved our success rate and contributed to a reduction in the review days and number of review cycles. If Academic Medical Centers and industry will adopt or create a similar checklist to review their studies before submission, the quality of the submissions can be improved and the duration of review can be minimized.
Effect of seasonal and temperature variation on hospitalizations for stroke over a 10-year period in Brazil
Authors: Kurtz Pedro , Bastos Leonardo SL , Aguilar Soraida , Hamacher Silvio , Bozza Fernando A 
Published: August 2020

Background Seasonal variation in stroke incidence remains controversial. Aims We aimed to describe the pattern of seasonality in hospitalizations for stroke in Brazil. Methods We evaluated age-adjusted hospitalization rates for stroke per month using data from the Brazilian Unified Healthcare System and median monthly temperature data obtained from the National Institute of Meteorology. To detect a seasonality pattern in time series, we used seasonal-trend decomposition using LOESS. We calculated a seasonal strength statistic and used Kruskal–Wallis test to evaluate the presence of seasonality in Brazil and its five regions. We also assessed the association of temperature and stroke hospitalization rates using Spearman’s rho correlation. Results We identified 1,422,496 stroke-related hospitalizations between 2009 and 2018. Mean age was 67 years, 51% were male and 77.5% of stroke diagnoses were not specified as ischemic or hemorrhagic. Median temperature was 23.8℃ (IQR 22.3–24.4). Age-adjusted hospitalizations demonstrated significant seasonal variation during all the years analyzed, with increased rates during the winter. When regional differences were analyzed, seasonal behavior was present in the south, southeast and northeast regions of the country. These were also the regions with lower median temperatures during the winter months and greater amplitude of average temperatures between warmer and colder months. Conclusions In this large national cohort of stroke patients in Brazil, we demonstrated the presence of seasonal variation in the age-adjusted hospitalization rate, with peak rates during the winter months. The regional gradient of incidence of stroke was directly associated with colder winters and greater amplitude of temperature.
Use of Computer Vision to Identify the Frequency and Magnitude of Insulin Syringe Preparation Errors
Authors: Cabri Ann , Bagley Berit , Brown Kevin 
Published: August 2020

Background: No current technology exists to ensure the dose of insulin administered in hospitals matches the physician order. Objective: Assess the feasibility of using computer vision to identify insulin syringe preparation errors. Methods: Twenty-two nurses prepared 50 insulin doses (n=1100) each. A computer vision device (CVD) measured the volume drawn up and identified air present. Syringes identified as inaccurate by the CVD were confirmed by two observers, and a random sample of 100 syringes identified as accurate was validated by two independent observers. Results: Ten syringes (1.0%) had the wrong volume prepared, and 68 syringes (6.5%) contained air sufficient to meet the definition of inaccuracy. All errors were confirmed by two independent observers. Conclusion: CVDs could reduce insulin administration errors in hospitalized patients.
Information asymmetries in intrafamily business succession
Authors: Wolff Sven , Schell Sabrina , Moog Petra 
Published: August 2020

The often long-lasting process of intrafamily business succession involves contracts for management and ownership transfer that unfold in a complex series of stages. The older and larger a family business, the more heterogeneous the involved family members’ interactions and interests can become. These differences become obvious in the succession process. Also, in entrepreneurial families, information is not easy to obtain and is neither perfect nor unlimited, for example, with regard to expectations regarding the duration or the type of business succession. Information asymmetries can arise. This article investigates the drivers of information asymmetries and provides insight into the current research by investigating information asymmetries and their impact during different phases of intrafamily business succession. Data from 215 German firms reveal the occurrence of specific information asymmetries during different phases of intrafamily business succession. JEL CLASSIFICATION M1; M59; D82; L2
Sonography of Magnetically Controlled Growing Rods: A Quality Initiative in the Creation of a Multidisciplinary Clinic
Authors: Riemann Monique C. , Bailey Smita S. , Rubert Nicholas , Barnes Craig E. , Karlen Judson W. 
Published: August 2020

Objective: The MAGEC (Magnetic Expansion Control) rods were introduced to a medical institution in 2015. The rod expansion procedures were initially evaluated with radiographs. The staff undertook a quality initiative to reduce radiation exposure by utilizing sonography. Material and Methods: The radiation dose for a typical visit was measured by examining DICOM imaging data, stored in PACS. Imaging visit time was determined from the difference between times of first radiograph/sonogram before distraction to last radiograph/sonogram after distraction. Results: The 21 patients (8 male, 13 female) were an average age of 11.4 ± 2.82 years (age at implant = 7.5 ± 1.94) when evaluated. The average length of time for a radiographic visit was 40.7 ± 20.7 minutes, whereas a sonography visit was 10.7 ± 3.7 minutes. Radiation dose per study visit prior to the introduction of the MAGEC clinic was 0.42 ± 0.39 mSv. Given an ideal patient schedule, the MAGEC clinic could reduce radiation dose by 1.3 to 2.5 mSv annually, with 95% confidence. Conclusion: This quality improvement study demonstrated a reduction in radiation exposure and imaging time. The added benefits were providing a successful multidisciplinary imaging clinic and creation of a new exam that aligned with the “ultrasound first” initiative.