bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improvement in Cardiovascular Autonomic Neuropathy After High-Dose Vitamin D Supplementation in Patients With Type 1 Diabetes
Authors: Silva Lilian de Souza D’Albuquerque , de Queiroz Natércia Neves Marques , de Melo Franciane Trindade Cunha , Abrahão Neto João Felício , Janaú Luísa Corrêa , de Souza Neto Norberto Jorge Kzan , de Lemos Manuela Nascimento , de Oliveira Maria Clara Neres Iunes , de Alcântara Angélica Leite , de Moraes Lorena Vilhena , da Silva Wanderson Maia , de Souza Ícaro José Araújo , Said Nivin Mazen , de Lemos Gabriela Nascimento , Felício Karem Miléo , Santos Márcia Costa dos , Motta Ana Regina Bastos , dos Reis Melissa de Sá Oliveira , Lobato Isabel Jane Campos , de Figueiredo Priscila Boaventura Barbosa , de Souza Ana Carolina Contente Braga , Piani Pedro Paulo Freire , Felício João Soares 
Published: November 2020

BackgroundCardiovascular autonomic neuropathy (CAN) is associated with diabetes mellitus, increasing morbidity and mortality. Some cross-sectional studies associated CAN with low 25-hydroxyvitamin D levels. The aim of our study was to evaluate the effect of high-dose vitamin D (VD) supplementation on CAN in Type 1 Diabetes Mellitus (T1DM) patients.MethodsWe performed a prospective study with 23 patients diagnosed with T1DM and CAN. Subjects with VD levels &lt;30 ng/ml received 10,000 IU/day; the ones with VD levels between 30–60 ng/ml were given 4,000 IU/day for 12 weeks.ResultsThere was an improvement in CAN parameters related to resting heart rate variability, such as time domain parameters [Maximum RR interval (0.77 ± 0.11 vs 0.94 ± 0.51 s, p &lt;0.05), Mean length of regular RR intervals (0.71 ± 0.10 vs 0.76 ± 0.09 s, p &lt;0.05) and Standard deviation of all NN intervals (0.02 ± 0.01 vs 0.03 ± 0.02 s; p &lt;0.01)] and frequency domain parameters [Low Frequency (1.9 ± 0.5 vs 2.5 ± 0.9 s, p &lt; 0.001), Total Power (2.5 ± 0.4 vs 2.8 ± 0.6 s, p &lt;0.05)]. In addition, there was a correlation between absolute VD level variation and posttreatment High Frequency (%), as well as among percent variation in VD level and end-of-study Low Frequency/High Frequency ratio (r=0.6, p&lt;0.01; r= -0.5, p&lt;0.05, respectively).ConclusionOur pilot study is the first to suggest a strong association between high-dose vitamin D supplementation and improved cardiovascular autonomic neuropathy in T1DM patients. It occurred without any variation in HbA1C, blood pressure levels, lipids, and insulin dose.Clinical Trial Registrationhttp://www.isrctn.com/ISRCTN32601947, identifier ISRCTN32601947.
Nutritional Support and Clinical Outcome of Severe and Critical Patients With COVID-19 Pneumonia
Authors: Yue Xiangfeng , Li Min , Wang Yu , Zhang Jing , Wang Xinyi , Kan Linwei , Zhang Xiaojian , Du Shuzhang 
Published: November 2020

Background: In 2020, a novel coronavirus has spread throughout the world. More than four hundred thousand people have died of SARS-CoV-2 pneumonia, most of which were severe and critical patients. No effective antiviral treatment has been verified thus far. Nutrition support has become one of the important treatments for severe and critical patients.Methods: In this retrospective study, 26 severe patients and 22 critical patients with laboratory confirmed COVID-19 were enrolled. We recorded the diet and nutritional treatments in severe and critical patients. Baseline characteristics and clinical outcomes of severe and critical patients were also collected.Results: Average calorie intake of severe patients (19.3 kcal/kg/d) was higher than critical patients (15.3 kcal/kg/d) (P = 0.04). Protein intake was similar in the two groups (0.65 and 0.62 g/kg per day, respectively; P = 0.29). There was no significant difference in the median duration of viral shedding between the severe and critical patients (P = 0.354).Conclusions: A permissive underfeeding strategy that restricts non-protein calories but preserves protein intake is feasible for critical patients with SARS-CoV-2 pneumonia. Viral shedding duration of critical patients was the same as severe patients who received standard feeding. Nevertheless, evidence of the conclusion is not sufficient because of small sample size. To show the real clinical benefit of permissive low-calorie and adequate protein intake in critical SARS-CoV-2 pneumonia patients, a large and pragmatic randomized controlled trial is needed.
The Impact of Obesity and Lifestyle on the Immune System and Susceptibility to Infections Such as COVID-19
Authors: de Frel Daan L. , Atsma Douwe E. , Pijl Hanno , Seidell Jacob C. , Leenen Pieter J. M. , Dik Willem A. , van Rossum Elisabeth F. C. 
Published: November 2020

Background: COVID-19 is a global challenge to healthcare. Obesity is common in patients with COVID-19 and seems to aggravate disease prognosis. In this review we explore the link between obesity, chronic disease, lifestyle factors and the immune system, and propose societal interventions to enhance global immunity.Search Strategy and Selection Criteria: We performed three literature searches using the keywords (1) coronavirus AND comorbidities, (2) comorbidities AND immune system, and (3) lifestyle factors AND immune system. Results were screened for relevance by the main author and a total of 215 articles were thoroughly analyzed.Results: The relationship between obesity and unfavorable COVID-19 prognosis is discussed in light of the impact of chronic disease and lifestyle on the immune system. Several modifiable lifestyle factors render us susceptible to viral infections. In this context, we make a case for fostering a healthy lifestyle on a global scale.Conclusions: Obesity, additional chronic disease and an unhealthy lifestyle interactively impair immune function and increase the risk of severe infectious disease. In adverse metabolic and endocrine conditions, the immune system is geared toward inflammation. Collective effort is needed to ameliorate modifiable risk factors for obesity and chronic disease on a global scale and increase resistance to viruses like SARS-CoV-2.
Ecos dissonantes no atlântico
Authors: Machado Mota Bento 
Published: November 2020

Este artigo pretende lançar luz sobre as ideias antiescravistas de missionários capuchinhos em fins do século XVII a partir do livro La Justa defesa (1681), do capuchinho francês Epifanio Moirans. Trata-se de um registro incomum, no qual diversos argumentos contra a escravidão são abordados, por um lado, à luz de justificativas jurídicas relativas ao tráfico negreiro vindas de Roma e de teólogos europeus e, por outro, por meio dos relatos missionários católicos da América do sul. Assim, a partir de Moirans pretende-se inserir o movimento antiescravista dos capuchinhos seiscentistas ao longo do pensamento teológico atlântico sobre escravidão.
Religious Conflict in Terms of Martin Heidegger's Philosophy of Existentialism
Authors: Pramono Adi Tri 
Published: November 2020

This paper aims to provide an overview of the process and construction of religious conflict, including genealogy, forms, and analysis of religious conflict causes. Further, this research also provides an in-depth analysis of religious conflicts from Martin Heidegger's existentialist philosophy. The methodology employed in this paper is hermeneutics. The research result indicates that the root of religious conflict is fear in facing increasingly modern life. The existence of this fear reduces the presence of the possibility. In the context of Martin Heidegger's existentialist philosophy, the experience is a process of being as Dasein to exist. Therefore religious conflict tends to be taken as a priority decision due to the lack of awareness of existential possibilities. The paper contributes to society in the sense that education must be accessible without any obstacles because, through knowledge, a broader perspective can be obtained since the right to education must be placed prior the right to exist.
PENGARUH CORPORATE GOVERNANCE TERHADAP PROFITABILITAS DENGAN MEDIASI LEVERAGE PADA PERUSAHAAN BUMN DALAM BEI
Authors: Sabatanta Boyke Daniel , Simbolon Richard F 
Published: November 2020

Tujuan penelitian ini adalah menguji dan menganalisis pengaruh corporate governance terhadap profitabilitas menggunakan leverage sebagai variabel mediasi. Sampel sebanyak 20 perusahaan BUMN yang terdaftar di Bursa Efek Indonesia periode 2017-2018 sehingga diperoleh sebanyak 40 observasi. Teknis analisis menggunakan analisis regresi linear berganda. Hasil penelitian menyimpulkan bahwa corporate governance secara signifikan berpengaruh terhadap leverage dan profitabilitas. Lebih lanjut dibuktikan bahwa leverage secara signifikan mempengaruhi profitabilitas. Leverage secara meyakinkan terbukti memediasi pengaruh corporate governance terhadap profitabilitas
LOKASI USAHA DAN FASILITAS PELAYANAN SEBAGAI DETERMINAN KEPUTUSAN PEMBELIAN
Authors: Lestari Suci Putri , Sutrisna Arga , Mafazi Muhammad 
Published: November 2020

Tujuan dari penelitian ini adalah untuk menguji dan menganalisis pengaruh lokasi bisnis dan fasilitas terhadap keputusan konsumen hotel. Penelitian ini melibatkan 100 responden sebagai sampel yang merupakan pengguna jasa hotel. Pengujian hipotesis menggunakan regresi berganda. Hasil penelitian menjelaskan bahwa akses dan visibilitas berkontribusi signifikan sebagai indikator lokasi bisnis yang strategis. Arsitektur penempatan fasilitas, interior, kelengkapan fasilitas dan sirkulasi udara merupakan indikator penting dari variabel fasilitas pelayanan. Hasil penelitian membuktikan bahwa lokasi usaha dan fasilitas berpengaruh signifikan terhadap keputusan pembelian
AGLOMERACIÓN ECONÓMICA Y PROBLEMAS URBANOS EN EL CENTRO DE HERMOSILLO, SONORA.
Authors: Garza Daniel Fanco 
Published: November 2020

Los centros urbanos son piezas fundamentales de las ciudades en México, y en muchos casos, representan los orígenes de su fundación y actúan como espacios de diversidad y de actividad económica, concentrando una importante variedad comercial y de servicios, a los cuales acceden miles de habitantes de manera diaria y/o regularmente.
Si bien estos espacios son importantes y fungen como referencia de las ciudades, la misma concentración o aglomeración económica y comercial acarrea una serie de complejidades y problemas, dada la gran actividad que desarrollan y en la cual participan cantidad y diversidad de actores que hacen de la dinámica de estos centros urbanos un interesante sistema compuesto por varias partes interconectadas, cuyos vínculos crean información adicional no siempre visible u observable fácilmente.
En este ensayo se analizan este sistema de complejidades y particularidades, así como los actores involucrados, presentando a la vez los problemas del desarrollo urbano que concentra este espacio económico de la ciudad de Hermosillo.
VIVIENDA VERNÁCULA MAYO
Authors: Tostado Cosío Carlos Vicente 
Published: November 2020

La arquitectura vernácula ha sido, uno de los temas más recurrente de la habitabilidad, al ser, “per se”, el galeón para la búsqueda de respuestas a bienes ancestrales y develar muchos de los silencios de las culturas mesoamericanas asentadas en los territorios anteriores a la conquista. Pensar en el simple hecho de que no estamos solos en un universo desconocido, es en parte, testimonio del patrimonio histórico construido a partir de los escenarios de la diversa concepción de lo efímero del espacio encontrado, particularmente, al norte del país, y hace justo, el relato edificado de lo diferente idealizado de los habitantes del mundo prehispánico, cuando ceñida su condición a través de múltiples tamices que la identifican históricamente con diversas sociedades, grupos, estilos, plástica y hasta en la poética de sus espacios, las hace en muchas de las ocasiones y a partir de sus formas y materiales, hasta fascinantes.
El rescate y recuperación de los valores de esta arquitectura ancestral, hoy y en el futuro servirán para proponer y construir los espacios que desde luego estos pueblos han de seguir levantando y para las generaciones de arquitectos por venir, para aplicar conceptos y valores de una arquitectura que estando presente se niega a morir en términos de espacialidad y constructibilidad.
SEMIÓTICA EN EL DISEÑO DE ETIQUETAS
Authors: Olvera Cepeda Sandra Marcelina 
Published: November 2020

El presente articulo es una practica de investigación sobre la relación entre las conservas, la semiótica y el diseño tocando puntos importantes para obtener al final un producto.
La elaboración de conservas es una actividad que ha perdurado al pasar de los años, pero pocos saben qué son o cómo se hacen. Son un patrimonio cultural que tiene el riesgo de olvidarse y perderse de nuestra cultura. El diseño es una actividad no tan antigua y abarca muchas áreas; pero ¿qué puede ser mejor que el diseño para apoyar la recuperación de las tradiciones como son las conservas? Si bien no parece tener mucha relación, la verdad es que esta actividad tiene cargas semióticas importantes porque para aquellos que son conocedores de esta magnífica actividad tiene un significado especial además de que en algunos casos representa el sustento de sus vidas, por una parte. Por otro lado, existen tantos productos en el mercado que contienen químicos que perjudican a la salud y esto provoca que las personas busquen bienes naturales u orgánicos como las conservas, y qué mejor opción que ésta. Con base en lo anterior, se construye una imagen, que en este caso será un logo y una etiqueta en base a la semiótica para que las personas que tengan contacto con ellas puedan identificarlas fácilmente.
IMPLEMENTASI MANAJEMEN PENINGKATAN KINERJA GURU PADA MAN HUTAGODANG, KABUPATEN LABUHANBATU SELATAN
Authors: HARAHAP AZIDDIN 
Published: November 2020

Tidak dapat dipungkiri bahwa komponen utama pendidikan adalah guru. Peran strategis guru telah menyumbangkan 36% dalam menciptakan kualitas pendidikan. Meskipun demikian, hingga saat ini masih nampak ke permukaan problematika kinerja guru. Dimulai dari masih banyak di antara guru yang melaksanakan pembelajaran terhadap peserta didik tidak menyiapkan dan mengacu pada silabus dan RPP (Rencana Pelaksanaan Pembelajaran), guru tidak menguasai materi pembelajaran secara luas dan mendalam, proses pembelajaran lebih didominasi oleh guru daripada murid, orientasi pembelajaran yang bersifat kognitif dan mengejar subject matter daripada afektif dan psikomotorik dan aktivitas mengajar guru yang bersifat rutinitas belaka, kering dari nilai-nilai normatif berdasarkan panggilan jiwa, minat, bakat maupun idealismenya.Kesimpulan penelitian ini adalah: lembaga pendidikan Islam MAN Hutagodang, kabupaten Labuhanbatu Selatan telah dikelola dengan baik dengan menerapkan fungsi-fungsi manajemen: perencanaan, pengorganisasian, pelaksanaan/kepemimpinan dan pengawasan. Kelemahan terdapat pada fungsi perencanaan yang tidak disertai dengan rencana biaya, rencana pengawasan/evaluasi dan penanggungjawab program. Pengorganisasian dilakukan dengan menetapkan tupoksi (tugas pokok dan fungsi) guru dan jabatan tambahannya dan struktur organisasi MAN Hutagodang. Pelaksanaan kegiatan peningkatan kinerja guru adalah: Diklat KTSP, Diklat mata pelajaran, Diklat Prajabatan, MGMP dan bimbingan teman sejawat dengan tipe kepemimpinan kepala madrasah bersifat demokratis. Pengawasan kinerja guru dilakukan dengan supervisi kelas.
Unmanned Aircraft Systems in Crisis Management in Poland After 2007
Authors: Krasiński Wojciech 
Published: November 2020

This article discusses the employment of unmanned aircraft systems in crisis management in Poland after 2007. The conceptual framework and organization of crisis management in Poland is presented as an introduction to further discussion. This article then analyses capabilities of various categories of unmanned aircraft systems taking into account specific requirements of crisis management. This article also points at preliminary lessons learned from employment of unmanned aircraft systems for crisis management in Poland in recent years. Due attention is paid to missions and the organization of employment of unmanned aircraft systems in crisis management operations. Perspectives of employing unmanned aircraft systems in crisis management are presented in the final part of the article.
An Overview of Second Generation Nanoparticles− Nanostructure Lipid Carrier Drug Delivery System
Authors: Kumar Sahoo Prabhat , S.L Neha , Pannu Arzoo 
Published: November 2020

Lipids are used as vehicles for the preparation of various formulations prescribed for administrations, including emulsions, ointments, suspension, tablets, and suppositories. The first parental nano-emulsion was discovered from the 1950s when it was added to the intravenous administration of lipid and lipid-soluble substances. Lipid-based drug delivery systems are important nowadays. Solid nanoparticles (SLN) and Nanostructured lipid carriers (NLC) are very proficient due to the ease of production process, scale-up capability, bio-compatibility, the biodegradability of formulation components and other specific features of the proposed route. The administration or nature of the materials must be loaded into these delivery systems. The main objectives of this review are to discuss an overview of second-generation nanoparticles, their limitations, structures, and route of administration, with emphasis on the effectiveness of such formulations. NLC is the second generation of lipid nanoparticles having a structure like nanoemulsion. The first generation of nanoparticles was SLN. The difference between both of them is at its core. Both of them are a colloidal carrier in submicron size in the range of 40-1000 nm. NLC is the most promising novel drug delivery system over the SLN due to solving the problem of drug loading and drug crystallinity. Solid and liquid lipids combination in NLC formation, improve its quality as compare to SLN. NLC has three types of structures: random, amorphous, and multiple. The random structure containing solid-liquid lipids and consisting crystal and the liquid lipid irregular in shape; thereby enhance the ability of the lipid layer to pass through the membrane. The second is the amorphous structure. It is less crystalline in nature and can prevent the leakage of the loaded drug. The third type is multiple structures, which have higher liquid lipid concentrations than other types. The excipients used to form the NLC are bio-compatible, biodegradable and non-irritating, most of which can be detected using GRAS. NLC is a promising delivery system to deliver the drug through pulmonary, ocular, CNS, and oral route of administration. Various methods of preparation and composition of NLC influence its stability Parameters. In recent years at the educational level, the potential of NLC as a delivery mechanism targeting various organs has been investigated in detail.
Perancangan Sistem Informasi Persediaan Barang Berbasis Web pada Alzena Hijab Store Banjarmasin
Authors: Najwaini Effan , Purnama Purnama , Rizki Aulia Nur 
Published: November 2020

Pada era teknologi informasi seperti sekarang ini, efisiensi waktu dan tenaga, serta kemudahan dalam mendapatkan suatu informasi sangatlah dibutuhkan. Dalam sebuah usaha toko kecepatan dalam pengolahan data sangatlah penting. Oleh karena itu, harus ditunjang dengan sarana dan prasarana yang memadai. Pada toko ini masih menggunakan sistem komputer manual dengan mencatat semua data menggunakan aplikasi Microsoft office excel sehingga proses penelusuran laporan barang masuk dan keluar menjadi lama karena melihat sheet by sheet . Sehingga sangat dibutuhkan suatu sistem yang dapat mengatasi masalah tersebut. Pada penelitian ini akan dibuat aplikasi sistem yang mampu memberikan informasi untuk laporan persediaan barang secara cepat dan tepat. Untuk membangun sistem tersebut, maka dapat dilakukan pembuatan aplikasi berbasis web dengan menggunakan framework PHP sebagai kode programnya dan MySQL sebagai basisdatanya. Adapun langkah-langkah penelitiannya meliputi: analisa kebutuhan sistem, desain sistem, pembuatan kode program, pengujian, dan pemeliharaan. Aplikasi sistem informasi yang dibuat dalam penelitian ini memberikan kontribusi yang cukup berarti bagi toko tersebut. Hasil penelitian akan menghasilkan sebuah sistem informasi persediaan barang berbasis website yang memberikan kemudahan dalam mengelola persediaan barang.
PRÁTICAS PARA PUBLICAÇÃO DE DADOS CONECTADOS
Authors: De Oliveira Chaves Jefferson , Leomar Todesco José 
Published: November 2020

A manutenção de conjuntos de dados conectados é uma atividade onerosa que envolve a utilização de diversos recursos, obedecer princípios e respeitar boas práticas. Assim esta revisão sistemática tem como objetivo realizar uma análise sobre as práticas utilizadas para a manutenção de dados conectados. Num universo de noventa e um artigos, chegou-se a um recorte de quinze trabalhos, nos quais esta revisão está baseada. É possível observar que há grande aderência aos princípios e algumas dificuldades com as boas práticas, indicando uma relativa consolidação de práticas em alguns pontos, enquanto há outros que ainda demandam uma atenção especial na construção de dados conectados.
Modelo Hibrido: Gestión del Cambio e innovación Social
Authors: Moreno R. Sidia , J. de Carrizo Elba 
Published: November 2020

Resumen:
La investigación consistió en la contrastación de dos enfoques utilizados en el desarrollo de proyectos de transformación social y organizacional de base tecnológica. Uno del ámbito social y el otro empresarial, para generar la fundamentación de un nuevo modelo híbrido que incorpore aspectos de ambos enfoques que fortalezcan procesos de cocreación, coejecución y de gestión del cambio organizacional en ambientes de crisis. Para ello, se realizó una evaluación cualitativa de las fases de la Metodología Sistémica e Integral del Cambio utilizada en el sector empresarial, y se comparó con las fases y criterios de los proyectos del Labotarorio de Innovación Social de la Universidad Tecnológica de Panamá. Se obtuvo la valoración integral de la metodología, en función del enfoque de innovación social y se identificaron características deseables en el modelo híbrido a proponer.
Proglacial icings as records of winter hydrological processes
Authors: Chesnokova Anna , Baraër Michel , Bouchard Émilie 
Published: November 2020

Abstract. The ongoing warming of cold regions is affecting
hydrological processes, causing deep changes, such as a ubiquitous increase
in river winter discharges. The drivers of this increase are not yet fully
identified mainly due to the lack of observations and field measurements in
cold and remote environments. In order to provide new insights into the
sources generating winter runoff, the present study explores the possibility
of extracting information from icings that form over the winter and are
often still present early in the summer. Primary sources detection was
performed using time-lapse camera images of icings found in both proglacial
fields and upper alpine meadows in June 2016 in two subarctic glacierized
catchments in the upper part of the Duke watershed in the St. Elias
Mountains, Yukon. As images alone are not sufficient to entirely cover a
large and hydrologically complex area, we explore the possibility of
compensating for that limit by using four supplementary methods based on
natural tracers: (a) stable water isotopes, (b) water ionic content, (c) dissolved organic carbon, and (d) cryogenic precipitates. The interpretation of
the combined results shows a complex hydrological system where multiple
sources contribute to icing growth over the studied winter. Glaciers of all
sizes, directly or through the aquifer, represent the major parent water
source for icing formation in the studied proglacial areas. Groundwater-fed
hillslope tributaries, possibly connected to suprapermafrost layers, make up
the other detectable sources in icing remnants. If similar results are
confirmed in other cold regions, they would together support a multi-causal
hypothesis for a general increase in winter discharge in glacierized
catchments. More generally, this study shows the potential of using icing
formations as a new, barely explored source of information on cold region
winter hydrological processes that can contribute to overcoming the paucity
of observations in these regions.