bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective Review and Analysis on Outcome of Cranioplasty: A Series of 38 Cases
Authors: K M Bazlul Karim  , Riad Habib  , Abu Tahir Mohammad Sahidullah Monsur  , Mithun Kumar Dey  , Atique Bin Hussain  , Adnan Moasir Hasnine  , Mamun Reza  , Dibakar Chaudhury  , Md Rezwan Radid  , Akas Biswas  , Kawshik Ahmed  , Mir Shamsad Hossain  , Aziza Khatun  , Md Arif Hasan  , Kazi Shahabulbul Islam  , Md Ashiqul Muhit Khan  , Md Ifran Ahmed  
Published: December 2024

Background: Cranioplasty is a straightforward procedure; it may result in a significant number of complications. These include infections, seizures, intracranial hematomas, and others. Objective: To evaluate the outcome following cranioplasty with titanium mesh-plate and screw. Materials and Methods: This retrospective study included patients who underwent decompressive craniectomy due to traumatic brain injury with raised intracranial pressure, acute subdural hematoma, compound comminuted skull fracture and intracranial hemorrhage, between January 2019 to December 2020 at Enam Medical College Hospital, Savar, Dhaka. Data were collected in pre-designed data collection sheet and were analyzed using computer-based programme statistical package for social science (SPSS) windows version 25.0. Results: This study showed maximum patients (34.2%) were between 21-30 years age. Majority (89.5%) were male and only 5.9% were female. Overall rate of complications was 10.5%. Among them new onset seizure was four, indrawing of skin through bone gap was four, hemorrhage was two, infection was one, hydrocephalus was one, and exposed implant also one. Conclusion: We have found the outcome of cranioplasty was better with titanium mesh plate and screw than conventional fixation of bone with polyglactin, polypropylene suture and titanium miniplate and screw. With polypropylene and polyglactin there is more chance of inward displacement of bone fragment and with miniplate and screw there is still chance of indrawing of bone fragment through the bone gap.
J Enam Med Col 2022; 12(2): 90−94
SIMULASI PROSES PENGECORAN DALAM TAHAPAN REVERSE ENGINEERING TOOLPOST MESIN BUBUT KONVENSIONAL
Authors: Dwiyanto Agus , Hasanudin  , Setiawan Muhammad Diki , Kurniawan  
Published: December 2024

Reverse engineering merupakan inovasi dalam pembuatan produk. Produk yang telah ada dianalisis untuk dilakukan pengembangan produk atau meningkatkan performa. Penelitian ini difokuskan pada penerapan metode reverse engineering untuk membuat toolpost, mengingat kebutuhan suku cadang toolpost mesin bubut konvensional masih bergantung pada impor dan seringkali tidak tersedia dipasaran karena pabrikan sudah tidak ada. Tahapan yang dilakukan meliputi pengumpulan informasi produk, analisis fitur fungsional, pengukuran dan pemodelan toolpost serta analisis keterbuatan melalui simulasi pengecoran. Simulasi pengecoran ini bertujuan untuk mengidentifikasi potensi cacat yang akan terjadi, sebelum desain toolpost akan diwujudkan dalam produk jadi. Hasil simulasi menunjukkan total cacat porositas sebesar 2% dengan lokasi cacat yaitu pada area gating system dan area lubang pada toolpost. Meskipun terdapat cacat, persentase dan lokasi cacat tersebut dapat dianggap tidak akan mempengaruhi keberfungsian dari toolpost. Waktu tuang optimal yaitu 2,38 detik dan waktu pendinginan yaitu 201,3 detik untuk mencegah terjadinya retak dan deformasi.
Layer-by-layer assembled film can serve as an enhanced reaction environment for Diels–Alder reaction
Authors: Fujisawa Nanami , Ebara Mitsuhiro 
Published: December 2024

Although the Diels–Alder reaction (DA) has garnered significant attention due to its numerous advantages, its long reaction time is a drawback. Herein, we investigated the effects of polarity difference on DA using Layer-by-Layer (LbL) films comprising polycationic polyallylamine hydrochloride and polyanionic poly (styrenesulfonic acid-co-furfuryl methacrylate) [poly (SS-co-FMA)] as the reaction environment. First, furan composition in poly (SS-co-FMA) was adjusted to be 19 mol% to achieve good water solubility and layer deposition. The successful formation of LbL films with 8 and 40 layers was confirmed by quartz crystal microbalance. The polarity within films and, consequently, the DA efficiency between furfuryl methacrylate and the maleimide in MAL-PEG2-NHS increased with an increasing number of layers up to 40 layers without requiring chemical modification on the reaction site of DA or any catalysts. Furthermore, we employed the LbL coating on the surface of magnetic nanoparticles (MNPs). The retro DA reaction (rDA) was successfully triggered by heating the MNPs by AC magnetic field. We believe that the proposed technology can serve as an enhanced DA reaction environment as well as temporal/spatial control of rDA in various applications.
Staged versus immediate complete revascularization for non-culprit arteries in acute myocardial infarction: a post-hoc analysis of FRAME-AMI
Authors: Lim Yongwhan , Jang Jaehyuk , Lee Seung Hun , Ahn Joon Ho , Hong Young Joon , Ahn Youngkeun , Jeong Myung Ho , Kim Chan Joon , Hahn Joo-Yong , Lee Joo Myung , Park Keun Ho , Choo Eun Ho , Ahn Sung Gyun , Doh Joon-Hyung , Lee Sang Yeub , Park Sang Don , Lee Hyun-Jong , Kang Min Gyu , Cho Yun-Kyeong , Nam Chang Wook , Bu Sung Hyun , Kim Min Chul 
Published: December 2024

Background and objectivesThe optimal timing for complete revascularization (CR) in patients with acute myocardial infarction (AMI) and multivessel disease (MVD) remain uncertain.MethodsThis post-hoc analysis of the FRAME-AMI trial included AMI patients with MVD (n = 549). They were classified into immediate (n = 329) and staged CR (n = 220) groups. All percutaneous coronary interventions were performed during inex hospitalization. The primary endpoint was a composite of all-cause death, acute myocardial infarction, and repeated revascularization. Secondary endpoints included each component of the primary endpoint. Additional comparisons for the outcomes in ST-segment elevation myocardial infarction (STEMI) and non-STEMI (NSTEMI) were also performed.ResultsThe incidence of the primary endpoint was not significantly different in any of the AMI patients [12.7% [immediate CR] vs. 17.4% [staged CR], p = 0.905, adjusted hazard ratio [HR] of staged CR = 0.81, 95% confidence interval = 0.43–1.53, p = 0.528]. Other secondary endpoints were also not significantly different. Analyses of STEMI and Neither the primary or secondary endpoints of NSTEMI patients were significantly different.ConclusionsIn this post-hoc analysis of the FRAME-AMI trial, no significant difference in clinical outcomes was observed between the immediate and staged CR strategies for AMI with MVD and the subgroups, such as STEMI or NSTEMI. However, the results should be interpreted carefully because of the many limitations, including a limited sample size and a lack of statistical power.
Trial Registration: FRAME-AMI clinicaltrials.gov, identifier (NCT02715518).
Leukocyte telomere length decreased the risk of mortality in patients with alcohol-associated liver disease
Authors: Yi Jiahong , Guo Hui , Jiang Chang , Duan Junyi , Xue Ju , Zhao Yue , He Wenzhuo , Xia Liangping 
Published: December 2024

BackgroundIt is necessary to find latent indicators to predict the survival of alcohol-associated liver disease (ALD) patients. Leukocyte telomere length (LTL) was regarded as an indicator of prognosis in several diseases. However, the relationships between LTL and survival as well as cause-specific mortality in ALD patients were still unknown.ObjectiveThis study aimed at exploring the underlying link between LTL and the risk of mortality in patients with ALD.MethodsThe LTL and survival data were gathered from the National Health and Nutrition Examination Survey (NHANES) 1999–2002. The connection between LTL and mortality was assessed by Cox regression models and stratified analyses. The non-linear relationship was explored by restricted cubic spline (RCS) analysis. Sensitivity analyses were used to evaluate the robustness of our findings.ResultsLTL was a negative factor for all-cause mortality (all p-value &lt; 0.05). The risk of cardiovascular disease (CVD)-related death was decreased in Q3 (p &lt; 0.001) and Q4 levels of LTL (p &lt; 0.001) compared with the Q1 group. Shorter LTL resulted in higher cancer-caused mortality (p = 0.03) in the Q2 group. Longer LTL improved survival especially for elder patients (p for trend &lt; 0.001) or men (p for trend = 0.001). Moreover, there were L-shaped correlations between LTL and all-cause mortality (p for non-linearity = 0.02), as well as cancer-related mortality (p for non-linearity &lt; 0.001). Four sensitivity analyses proved the robustness of our findings.ConclusionOur research found that longer LTL improved survival in patients with ALD and decreased CVD and cancer-related mortality. LTL decreased all-cause mortality especially for patients older than 65 years or men. LTL might be a useful biomarker for prognosis among patients with ALD. More prospective studies are needed to assess the relevance between LTL and mortality and explore the underlying mechanisms between them.
Association between visceral adipose surrogates and infertility among reproductive-aged females: a cross-sectional study
Authors: Guo Dongli , Wang Ruiya 
Published: December 2024

BackgroundVisceral adipose tissue (VAT) exerts a substantial influence on female infertility. Nevertheless, the relationship between VAT surrogates and female infertility remains ambiguous.MethodsThis study employed a cross-sectional design and analyzed data from the National Health and Nutrition Examination Survey (NHANES, 2012–2016). Weighted logistic regression models were utilized to examine the association between VAT surrogates and infertility. Furthermore, Receiver Operating Characteristic (ROC) curve analysis was conducted to assess the diagnostic efficacy of these surrogates for infertility.ResultsIndividuals experiencing infertility exhibited markedly elevated levels of the Chinese Visceral Adiposity Index (CVAI) (108.30 vs. 69.86, P&lt;0.001) and Visceral Adiposity Index (VAI) (1.68 vs. 1.35, P&lt;0.001). When considered as a continuous variable, CVAI (odds ratio [OR]: 1.06, 95% confidence interval [CI]: 1.03-1.09, P&lt;0.001), rather than VAI (OR:1.02, 95%CI: 0.98-1.06, P=0.259), demonstrated a significant association with the risk of female infertility. Consistent findings were also evident after dividing participants into 4 subgroups based on CVAI quartiles. Additionally, ROC curves indicated that CVAI exhibited the most robust diagnostic value for female infertility compared to other indices. Subgroup analyses revealed a robust association between CVAI and infertility across different populations.ConclusionFemales with elevated CVAI levels faced a significantly heightened risk of infertility in the United States. CVAI holds promise as a valuable tool for stratifying the risk of infertility.
Network meta-analysis of pharmacological treatment for antibody-mediated rejection after organ transplantation
Authors: Sun Junjie , Yu Yanqing , Huang Fu , Zhang Qiuwen , Zhu Lirong , He Guining , Li Haibin , Sun Xuyong 
Published: December 2024

ObjectiveThis study aims to assess the efficacy of pharmacological interventions in mitigating graft injury in transplant patients with antibody-mediated rejection (AMR) through a network meta-analysis (NMA).MethodsA search was conducted on databases such as Cochrane Library, PubMed, EmBase, and Web of Science for randomized controlled trials (RCTs) on pharmacological interventions for alleviating graft injury following AMR. The search was performed for publications up to April 12, 2024. Two reviewers conducted independent reviews of the literature, extracted data, and assessed the risk of bias (ROB) in the included studies using the ROB assessment tool recommended by the Cochrane Handbook for Systematic Reviews of Interventions 5.1.0. A Bayesian NMA was conducted using R 4.4.0, RStudio software, and the GeMTC package to assess the outcomes in estimated glomerular filtration rate (eGFR), mean fluorescence intensity (MFI), g-score, and infection under pharmacological treatments.ResultsA total of 8 RCTs involving 215 patients and 6 different pharmacological treatments were included in this NMA. The results indicated that the increase in eGFR by eculizumab (SUCRA score: 81) appeared to be more promising. The decrease in MFI by bortezomib (SUCRA score: 72.3), rituximab (SUCRA score: 68.2), and clazakizumab (SUCRA score: 67.1) demonstrated better efficacy. The decrease in g-score by eculizumab (SUCRA score: 74.3), clazakizumab (SUCRA score: 72.2), and C1INH (SUCRA score: 63.6) appeared to have more likelihood. For infection reduction, clazakizumab (SUCRA score: 83.5) and bortezomib (SUCRA score: 66.8) might be better choices.ConclusionThe results of this study indicate that eculizumab has the potential to enhance eGFR and reduce g-score. Bortezomib demonstrates superior efficacy in reducing MFI. Clazakizumab appears to be more effective in reducing infections.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024546483.
Association of maternal dietary cholesterol intake during the second and third trimesters of pregnancy and blood glucose and pregnancy outcome in women with gestational diabetes mellitus: a prospective cohort study
Authors: Xie Cuiling , Zheng QingXiang , Jiang Xiumin , Liao Yanping , Gao Xiaoxia , Zhu Yu , Li Jianing , Liu Rulin 
Published: December 2024

BackgroundCholesterol is essential for pregnant women to maintain maternal health and fetal support development. This study aimed to assess the cholesterol intake of women with gestational diabetes mellitus (GDM) during the second and third trimesters of pregnancy and to explore its effects on blood glucose and pregnancy outcomes.MethodsThis prospective cohort study collected dietary data using a food frequency questionnaire (FFQ) administered during the 24–30 gestational weeks (first survey) and the 34–42 gestational weeks (second survey). Blood glucose parameters and pregnancy outcomes were obtained from electronic medical records. Participants were divided into two groups according to the median cholesterol intake: low and high cholesterol intake groups.ResultsGDM women generally consumed high levels of cholesterol during pregnancy, with intake increasing in the third trimester compared to the second trimester. Compared to women with high cholesterol intake, GDM women with low cholesterol intake had a higher risk of abnormal hemoglobin A1C (HbA1C) during the second trimester [OR 26.014 (95% CI 2.616–258.727)] and the third trimester [OR 2.773 (95% CI 1.028–7.482)], as well as abnormal fasting blood glucose during the third trimester [OR 2.907 (95% CI 1.011–8.360)]. Furthermore, in the second trimester, GDM women with high cholesterol intake had higher risks of macrosomia [OR 23.195 (95% CI 2.650–203.024)] and large for gestational age (LGA) [OR 3.253 (95% CI 1.062–9.965)] but lower risks of small for gestational age (SGA) [OR 0.271 (95% CI 0.074–0.986)] compared to those with low cholesterol intake. However, in the third trimester, GDM women with high cholesterol intake had lower risks of macrosomia [OR 0.023 (95% CI 0.001–0.436)] and LGA [OR 0.199 (95% CI 0.042–0.949)].ConclusionCholesterol intake among GDM women during pregnancy was associated with blood glucose control and significantly influenced the risks of macrosomia, LGA, and SGA. However, LGA and SGA were also influenced by pre-pregnancy BMI, indicating cholesterol intake was one of multiple contributing factors. Limiting cholesterol intake may help GDM women better manage blood glucose levels and mitigate adverse pregnancy outcomes.
Quantitative analysis of the caloric restriction versus isocaloric diets models based on macronutrients composition: impacts on body weight regulation, anthropometric, and bioimpedance parameters in women with obesity
Authors: Pescari Denisa , Mihuta Monica Simina , Bena Andreea , Stoian Dana 
Published: December 2024

IntroductionObesity is a growing public health issue, especially among young adults, with long-term management strategies still under debate. This prospective study compares the effects of caloric restriction and isocaloric diets with different macronutrient distributions on body composition and anthropometric parameters in obese women during a 12-week weight loss program, aiming to identify the most effective dietary strategies for managing obesity-related health outcomes.MethodsA certified clinical nutritionist assigned specific diets over a 12-week period to 150 participants, distributed as follows: hypocaloric diets—low-energy diet (LED, 31 subjects) and very low-energy diet (VLED, 13 subjects); isocaloric diets with macronutrient distribution—low-carbohydrate diet (LCD, 48 subjects), ketogenic diet (KD, 23 subjects), and high-protein diet (HPD, 24 subjects); and isocaloric diet without macronutrient distribution—time-restricted eating (TRE, 11 subjects). Participants were dynamically monitored using anthropometric parameters: body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR) and bioelectrical impedance analysis (BIA) using the TANITA Body Composition Analyzer BC-418 MA III (T5896, Tokyo, Japan) at three key intervals—baseline, 6 weeks, and 12 weeks. The following parameters were evaluated: body weight, basal metabolic rate (BMR), percentage of total body fat, trunk fat, muscle mass, fat-free mass, and hydration status.ResultsAll diets led to weight loss, but differences emerged over time. The TRE model resulted in significantly less weight loss compared to LED at the final follow-up (6.30 kg, p &lt; 0.001), similar to the VLED (4.69 kg, p &lt; 0.001). Isocaloric diets with varied macronutrient distributions showed significant weight loss compared to LED (p &lt; 0.001). The KD reduced waist circumference at both 6 and 12 weeks (−4.08 cm, p &lt; 0.001), while significant differences in waist-to-hip ratio reduction were observed across diet groups at 12 weeks (p = 0.01). Post-hoc analysis revealed significant fat mass differences at 12 weeks, with HPD outperforming IF (p = 0.01) and VLED (p = 0.003). LCD reduced trunk fat at 6 weeks (−2.36%, p = 0.001) and 12 weeks (−3.79%, p &lt; 0.001). HPD increased muscle mass at 12 weeks (2.95%, p = 0.001), while VLED decreased it (−2.02%, p = 0.031). TRE showed a smaller BMR reduction at 12 weeks compared to LED.ConclusionThis study highlights the superior long-term benefits of isocaloric diets with macronutrients distribution over calorie-restrictive diets in optimizing weight, BMI, body composition, and central adiposity.
Application of disitamab vedotin in the multiline treatment of EGFR mutation-positive lung adenocarcinoma with Her-2 overexpression
Authors: Lan Meiling , Wang Tianyun , Luo Diexiao , Chen Yan , Liang Wei , Kong Rui , Xie Qichao 
Published: December 2024

ObjectiveTo explore the efficacy of c in the multiline treatment of late-stage lung adenocarcinoma with Her-2 overexpression and epidermal growth factor receptor (EGFR) mutations.MethodsWe summarize the diagnosis and treatment of a female patient with EGFR 21L858R mutation combined with Her-2 overexpression in advanced lung adenocarcinoma, and analyze the effect of c in her treatment process.ResultsThe patient was diagnosed with lung adenocarcinoma 8 years ago. After first-line treatment, the lung lesions enlarged. Following second-line treatment 5 years ago, intracranial metastasis occurred. After third-line treatment 3 years ago, intracranial and lung lesions enlarged. New lesions in the lungs, liver, and spleen appeared after fourth-line treatment 32 months ago. Lung progression occurred after fifth-line treatment 29 months ago. Liver and lung progression occurred after sixth-line treatment 22 months ago. Lung progression occurred after seventh-line treatment 19 months ago. The patient underwent eighth-line treatment with disitamab vedotin (RC48) + lung radiotherapy + liver intervention 13 months ago. Currently, the patient’s condition is stable, with a good quality of life, and the efficacy assessment is stable disease (SD). Conclusion: Her-2 overexpression can occur in late-stage EGFR-mutant lung adenocarcinoma after multiline treatment. RC48 can achieve sustained remission in these patients.
Quality of pediatric trauma care: development of an age-adjusted TRISS model and survival benchmarking in a major trauma center
Authors: De los Ríos-Pérez Ana , García Alberto Federico , Gomez Paula , Arias Juan José , Fandiño-Losada Andrés 
Published: December 2024

BackgroundPediatric trauma is a major global health concern, accounting for a substantial proportion of deaths and disease burden from age 5 onwards. Effective triage and management are essential in pediatric trauma care, and prediction models such as the Trauma Injury Severity Score (TRISS) play a crucial role in estimating survival probability and guiding quality improvement. However, TRISS does not account for age-specific factors in pediatric populations, limiting its applicability to younger patients. This study aimed to modify TRISS to account for age for children (Peds-TRISS) and to evaluate its performance relative to the original TRISS. We also assessed survival outcomes to explore the model's potential utility across various clinical settings. These efforts align with quality improvement initiatives to reduce preventable mortality and supporting sustainable development goals.MethodsThis retrospective cohort study included patients under 18 years of age who were treated at a hospital in Colombia between 2011 and 2019. New coefficients for TRISS covariates were calculated using logistic regression, with age treated as a continuous variable. Model performance was evaluated based on discrimination (C statistic) and calibration, comparing Peds-TRISS with the original TRISS. Internal validation was conducted using bootstrap resampling. Survival outcomes were assessed using the M and Z statistics, which are commonly used for international trauma outcome comparisons.ResultsThe study included 1,013 pediatric patients with a median age of 12 years (IQR 5–15), of whom 73% were male. The leading causes of injury were traffic accidents (31.1%), falls (28.8%), and assaults (28.7%). The overall mortality rate was 5.7%. The Peds-TRISS model demonstrated good calibration (HL = 9.7, p = 0.3) and discrimination (C statistic = 0.98, 95% CI 0.97–0.99), with no statistically significant difference in the ROC curve comparison with the original TRISS. Internal validation demonstrated strong performance of Peds-TRISS. The M and Z statistics were 0.93 and 0, respectively, indicating no significant differences between expected and observed survival rates.ConclusionsMost fatalities occurred among adolescents and were due to intentional injuries. The Peds-TRISS model showed a partial improvement in performance compared to the original TRISS, with superior results in terms of calibration, although not in discrimination. These findings highlight the potential of model customization for specific populations. Prospective, multicenter studies are recommended to further validate the model's utility across diverse settings.