bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chapter 17 Accretionary orogens reworked in an overriding plate setting during protracted continent–continent collision, Sveconorwegian orogen, southwestern Sweden
Authors: Stephens Michael B. , Wahlgren Carl-Henric 
Published: January 2020

Abstract

The Eastern Segment in the Sveconorwegian orogen, southwestern Sweden, is dominated by 2.0–1.8, 1.7 and 1.5–1.4 Ga crust; and the overlying Idefjorden terrane by 1.6–1.5 Ga crust. Assuming reorganization of a subduction system prior to 1.5–1.4 Ga and applying a sinistral transpressive component of disruption during the subsequent Sveconorwegian orogeny (1.1–0.9 Ga), the Idefjorden terrane is inferred to be indigenous outboard rather than exotic with respect to the continental plate Fennoscandia (Baltica). The geological record then records successive westwards shift of accretionary orogens along a convergent plate boundary for at least 500 million years. Sveconorwegian foreland-younging tectonic cycles at
c.
1.05 (or older)–1.02 Ga (Idefjorden terrane) and at
c.
0.99–0.95 Ga (Eastern Segment) prevailed. Crustal thickening and exhumation during oblique convergence preceded migmatization, magmatic activity and a changeover to an extensional regime, possibly triggered by delamination of continental lithosphere, in each cycle. Convergence after 0.95 Ga involved antiformal doming with extensional deformation at higher crustal levels (Eastern Segment) and continued magmatic activity (Idefjorden terrane). An overriding plate setting is inferred during either accretionary orogeny or, more probably, protracted continent–continent collision. Continuity of the erosional fronts in the Grenville and Sveconorwegian orogens is questioned.
Chapter 1 Introduction to the lithotectonic framework of Sweden and organization of this Memoir
Authors: Stephens Michael B. 
Published: January 2020

Abstract
The solid rock geology of Sweden comprises three principal components: (1) Proterozoic and (locally) Archean rocks belonging to the western part of the Fennoscandian Shield; (2) Phanerozoic and (locally) Neoproterozoic sedimentary cover rocks deposited on top of this ancient crust; and (3) the early to mid-Paleozoic (0.5–0.4 Ga) Caledonide orogen. Earlier compilations have applied different principles for the subdivision of the geology in the Fennoscandian Shield and the Caledonide orogen. A uniform lithotectonic framework has been developed here. Crustal segments affected by orogenesis have been identified and their ages determined by the youngest tectonothermal event. Four ancient mountain belts and six orogenies are preserved. Solid rocks outside the orogens have been assigned to different magmatic complexes or sedimentary successions based on their time of formation and tectonic affiliation. This approach allows relicts of older mountain-building activity to be preserved inside a younger orogen – for example, the effects of the Archean (2.8–2.6 Ga) orogeny inside the 2.0–1.8 Ga Svecokarelian orogen and Paleo–Mesoproterozoic (1.7–1.5 and 1.5–1.4 Ga) mountain-building processes inside the 1.1–0.9 Ga Sveconorwegian orogen. Sweden's five largest mineral districts are addressed in the context of this new lithotectonic framework, which forms the architecture to the contents of the chapters in this Memoir.
Advanced glycation end products induce immature angiogenesis in in vivo and ex vivo mouse models
Authors: Chen Lixian , Cui Yun , Li Bingyu , Weng Jie , Wang Weiju , Zhang Shuangshuang , Huang Xuliang , Guo Xiaohua , Huang Qiaobing 
Published: January 2020

Proliferative diabetic retinopathy (PDR) is a progressive disease predominantly involving pathological angiogenesis and is characterized by the development of immature, fragile, and easily hemorrhagic new vessels. Advanced glycation end products (AGEs) and the receptor for AGEs (RAGE) play important roles in the progression of diabetic retinopathy. Our previous studies demonstrated that AGEs promoted HUVEC angiogenesis by inducing moesin phosphorylation via RhoA/Rho-associated protein kinase (ROCK) pathway. The aim of this study was to further confirm AGE-induced angiogenesis in vivo and the involvement of RAGE, ROCK, and moesin phosphorylation in this process. We performed the study in an AGE-treated mouse model with various angiogenesis assays in multiple in vivo and ex vivo models. The results demonstrated that AGEs promoted significant neovascularization in whole mount retina and mouse aortic ring of adult and postnatal mice and in Matrigel plug as well, which were consistently accompanied by increased moesin phosphorylation. The increase of AGE-evoked neovascularization and moesin phosphorylation were both attenuated by RAGE knockout or ROCK inhibitor Y27632 administration in mice. We also revealed the pathological characteristics of AGE-promoted angiogenesis by demonstrating the decrease of pericyte coverage and the disarranged endothelial alignment in microvessels. In conclusion, this study provides in vivo evidences that AGEs induce immature angiogenesis by binding to RAGE, activating the RhoA/ROCK signal pathway and inducing moesin phosphorylation. NEW & NOTEWORTHY Advanced glycation end product (AGE)-induced formation of neovessels and phosphorylation of moesin in retina and aortic ring required AGE receptors. AGEs increased neovessels and the phosphorylation of moesin in retina and aortic ring via RhoA/ROCK pathway. AGE-induced immature angiogenesis in AGE-treated mouse retina and aortic ring. The AGE-RAGE axis and moesin could be candidate targets for overcoming relative diseases.
PKCβ and reactive oxygen species mediate enhanced pulmonary vasoconstrictor reactivity following chronic hypoxia in neonatal rats
Authors: Sheak Joshua R. , Yan Simin , Weise-Cross Laura , Ahmadian Rosstin , Walker Benjimen R. , Jernigan Nikki L. , Resta Thomas C. 
Published: January 2020

Reactive oxygen species (ROS), mitochondrial dysfunction, and excessive vasoconstriction are important contributors to chronic hypoxia (CH)-induced neonatal pulmonary hypertension. On the basis of evidence that PKCβ and mitochondrial oxidative stress are involved in several cardiovascular and metabolic disorders, we hypothesized that PKCβ and mitochondrial ROS (mitoROS) signaling contribute to enhanced pulmonary vasoconstriction in neonatal rats exposed to CH. To test this hypothesis, we examined effects of the PKCβ inhibitor LY-333,531, the ROS scavenger 1-oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine (TEMPOL), and the mitochondrial antioxidants mitoquinone mesylate (MitoQ) and (2-(2,2,6,6-tetramethylpiperidin-1-oxyl-4-ylamino)-2-oxoethyl)triphenylphosphonium chloride (MitoTEMPO) on vasoconstrictor responses in saline -perfused lungs (in situ) or pressurized pulmonary arteries from 2-wk-old control and CH (12-day exposure, 0.5 atm) rats. Lungs from CH rats exhibited greater basal tone and vasoconstrictor sensitivity to 9,11-dideoxy-9α,11α-methanoepoxy prostaglandin F2α (U-46619). LY-333,531 and TEMPOL attenuated these effects of CH, while having no effect in lungs from control animals. Basal tone was similarly elevated in isolated pulmonary arteries from neonatal CH rats compared with control rats, which was inhibited by both LY-333,531 and mitochondria-targeted antioxidants. Additional experiments assessing mitoROS generation with the mitochondria-targeted ROS indicator MitoSOX revealed that a PKCβ-mitochondrial oxidant signaling pathway can be pharmacologically stimulated by the PKC activator phorbol 12-myristate 13-acetate in primary cultures of pulmonary artery smooth muscle cells (PASMCs) from control neonates. Finally, we found that neonatal CH increased mitochondrially localized PKCβ in pulmonary arteries as assessed by Western blotting of subcellular fractions. We conclude that PKCβ activation leads to mitoROS production in PASMCs from neonatal rats. Furthermore, this signaling axis may account for enhanced pulmonary vasoconstrictor sensitivity following CH exposure. NEW & NOTEWORTHY This research demonstrates a novel contribution of PKCβ and mitochondrial reactive oxygen species signaling to increased pulmonary vasoconstrictor reactivity in chronically hypoxic neonates. The results provide a potential mechanism by which chronic hypoxia increases both basal and agonist-induced pulmonary arterial smooth muscle tone, which may contribute to neonatal pulmonary hypertension.
Proteomic Analysis of CSF from Patients with Leptomeningeal Melanoma Metastases Identifies Signatures Associated with Disease Progression and Therapeutic Resistance
Authors: Smalley Inna , Law Vincent , Wyatt Clayton , Evernden Brittany , Fang Bin , Koomen John M. , Welsh Eric A. , Macaulay Robert J.B. , Forsyth Peter A. , Smalley Keiran S.M. 
Published: January 2020

AbstractPurpose:The development of leptomeningeal melanoma metastases (LMM) is a rare and devastating complication of the late-stage disease, for which no effective treatments exist. Here, we performed a multi-omics analysis of the cerebrospinal fluid (CSF) from patients with LMM to determine how the leptomeningeal microenvironment shapes the biology and therapeutic responses of melanoma cells.Experimental Design:A total of 45 serial CSF samples were collected from 16 patients, 8 of these with confirmed LMM. Of those with LMM, 7 had poor survival (&lt;4 months) and one was an extraordinary responder (still alive with survival &gt;35 months). CSF samples were analyzed by mass spectrometry and incubated with melanoma cells that were subjected to RNA sequencing (RNA-seq) analysis. Functional assays were performed to validate the pathways identified.Results:Mass spectrometry analyses showed the CSF of most patients with LMM to be enriched for pathways involved in innate immunity, protease-mediated damage, and IGF-related signaling. All of these were anticorrelated in the extraordinary responder. RNA-seq analysis showed CSF to induce PI3K/AKT, integrin, B-cell activation, S-phase entry, TNFR2, TGFβ, and oxidative stress responses in the melanoma cells. ELISA assays confirmed that TGFβ expression increased in the CSF of patients progressing with LMM. CSF from poorly responding patients conferred tolerance to BRAF inhibitor therapy in apoptosis assays.Conclusions:These analyses identified proteomic/transcriptional signatures in the CSF of patients who succumbed to LMM. We further showed that the CSF from patients with LMM has the potential to modulate BRAF inhibitor responses and may contribute to drug resistance.See related commentary by Glitza Oliva and Tawbi, p. 2083
Characterization of Structural Changes in Arrhythmogenic Right Ventricular Cardiomyopathy With Recurrent Ventricular Tachycardia After Ablation
Authors: Briceño David F. , Liang Jackson J. , Shirai Yasuhiro , Markman Timothy M. , Chahal Anwar , Tschabrunn Cory , Zado Erica , Hyman Mathew C. , Kumareswaran Ramanan , Arkles Jeffery S. , Santangeli Pasquale , Schaller Robert D. , Supple Gregory E. , Frankel David S. , Deo Rajat , Riley Michael P. , Nazarian Saman , Lin David , Epstein Andrew E. , Garcia Fermin C. , Dixit Sanjay , Callans David J. , Marchlinski Francis E. 
Published: January 2020

Background:
Data characterizing structural changes of arrhythmogenic right ventricular (RV) cardiomyopathy are limited.

Methods:
Patients presenting with left bundle branch block ventricular tachycardia in the setting of arrhythmogenic RV cardiomyopathy with procedures separated by at least 9 months were included.

Results:

Nineteen consecutive patients (84% males; mean age 39±15 years [range, 20–76 years]) were included. All 19 patients underwent 2 detailed sinus rhythm electroanatomic endocardial voltage maps (average 385±177 points per map; range, 93–847 points). Time interval between the initial and repeat ablation procedures was mean 50±37 months (range, 9–162). No significant progression of voltage was observed (bipolar: 38 cm
2
[interquartile range (IQR), 25–54] versus 53 cm
2
[IQR, 25–65],
P
=0.09; unipolar: 116 cm
2
[IQR, 61–209] versus 159 cm
2
[IQR, 73–204],
P
=0.36) for the entire study group. There was a significant increase in RV volumes (percentage increase, 28%; 206 mL [IQR, 170–253] versus 263 mL [IQR, 204–294],
P
<0.001) for the entire study population. Larger scars at baseline but not changes over time were associated with a significant increase in RV volume (bipolar: Spearman ρ, 0.6965,
P
=0.006; unipolar: Spearman ρ, 0.5743,
P
=0.03). Most patients with progressive RV dilatation (8/14, 57%) had moderate (2 patients) or severe (6 patients) tricuspid regurgitation recorded at either initial or repeat ablation procedure.

Conclusions:
In patients with arrhythmogenic RV cardiomyopathy presenting with recurrent ventricular tachycardia, >10% increase in RV endocardial surface area of bipolar voltage consistent with scar is uncommon during the intermediate term. Most recurrent ventricular tachycardias are localized to regions of prior defined scar. Voltage indexed scar area at baseline but not changes in scar over time is associated with progressive increase in RV size and is consistent with adverse remodeling but not scar progression. Marked tricuspid regurgitation is frequently present in patients with arrhythmogenic RV cardiomyopathy who have progressive RV dilation.
How to Found a New Dynasty: The Early Qajars’ Quest for Legitimacy
Authors: Kondo Nobuaki 
Published: January 2020

Abstract
This paper focuses on how early Qajars established their rule and legitimacy. At first, Āqā Mohammad Khān, the first shah, imitated other rulers since Nāder Shāh, such as Mohammad-Hasan Khān Qājār, Āzād Khān Afghān, and Karim Khān Zand, in his coins and documents. Like his predecessors, he also tried to install a Safavid prince at Tehran as a puppet ruler. However, following his official coronation and his conquest of Iran, he changed the format of his royal edicts and issued extraordinarily heavy gold coins. Nevertheless, neither Āqā Mohammad Khān nor his successors created an official genealogy to legitimize their rule, instead modifying a genealogical tree of Ottoman origin to juxtapose their names alongside those of other royal families without connecting themselves directly to Biblical or Qurʾanic ancestors. The early Qajar case reveals new methods of establishing dynastic legitimacy which differed from the approach of earlier dynasties in the Persianate world.
Spice and Barrier Layers: An Arabian Sea Case Study
Authors: Echols Rosalind , Riser Stephen C. 
Published: January 2020

AbstractBarrier layers (BLs) are a frequent occurrence in low-latitude oceans, but variations in identification methods and quantitative descriptors used, as well as analyses of their lifetimes, lead to differing views on their overall impact. Herein a new method is proposed for identifying BLs that relies on the vertical spice profile rather than arbitrary temperature thresholds. Using 13 years of Argo profiling float data from the Arabian Sea, this method is shown to produce reasonable assessments of BL characteristics in the region. Similarly, use of the spice variable to identify formation mechanisms shows promise for using limited observational data and climatology to reproduce mechanisms proposed from modeling studies. Upper-ocean stability calculations combining profiling float and atmospheric forcing data are used to suggest the most likely one-dimensional mechanisms for erosion of BLs and to calculate the expected lifetimes of BLs throughout the year. Consistent with the evidence about the seasonal spatial extent and frequency of BLs, their duration is expected to be 2–3 times longer during the northeast monsoon than the southwest monsoon. However, the most likely erosion mechanisms vary widely throughout the year, as do the associated changes to the upper-ocean structure and thus likely impacts on SST.
The Prevalence of Radiographic Findings of Structural Hip Deformities for Femoroacetabular Impingement in Patients With Hip Pain
Authors: Zhou Jun , Melugin Heath P. , Hale Rena F. , Leland Devin P. , Bernard Christopher D. , Levy Bruce A. , Krych Aaron J. 
Published: January 2020

Background:Radiography is the initial imaging modality used to evaluate femoroacetabular impingement (FAI), and diagnostic radiographic findings are well-established. However, the prevalence of these radiographic findings in patients with hip pain is unknown.Purpose:The purpose was 3-fold: (1) to determine the overall prevalence of radiographic FAI deformities in young patients presenting with hip pain, (2) to identify the most common radiographic findings in patients with cam-type FAI, and (3) to identify the most common radiographic findings in patients with pincer-type FAI.Study Design:Cross-sectional study; Level of evidence, 3.Methods:A geographic database was used to identify patients aged 14 to 50 years with hip pain between the years 2000 to 2016. The following were evaluated on radiographs: cam type: typical pistol grip deformity, alpha angle >55°; pincer type: crossover sign (COS), coxa profunda or protrusio acetabuli, lateral center edge angle (LCEA) ≥40°, Tönnis angle <0°; and mixed type: both cam- and pincer-type features. Posterior wall sign (PWS) and ischial spine sign (ISS) were also evaluated. The prevalence of each was determined. Descriptive statistics were performed on all radiographic variables.Results:There were 1893 patients evaluated, and 1145 patients (60.5%; 1371 hips; 374 male and 771 female; mean age, 28.8 ± 8.4 years) had radiographic findings consistent with FAI. Of these hips, 139 (10.1%) had cam type, 245 (17.9%) had pincer type, and 987 (72.0%) had mixed type. The prevalence of a pistol grip deformity and an alpha angle >55° was 577 (42.1%) and 1069 (78.0%), respectively. The mean alpha angle was 66.9°± 10.5°. The prevalence of pincer-type radiographic findings was the following: COS, 1062 (77.5%); coxa profunda, 844 (61.6%); ISS, 765 (55.8%); PWS, 764 (55.7%); Tönnis angle <0°, 312 (22.8%); LCEA ≥40°, 170 (12.4%); and protrusio acetabuli, 7 (0.5%).Conclusion:The overall prevalence of radiographic findings consistent with FAI in young patients with hip pain was 60.5%. Radiographic findings for mixed-type FAI were the most prevalent. The most common radiographic finding for cam-type FAI was an alpha angle >55°. The most common radiographic finding for pincer-type FAI was the COS.
Lipid-Lowering Therapy and Low-Density Lipoprotein Cholesterol (LDL-C) Goal Achievement in High-Cardiovascular-Risk Patients in Fuzhou, China
Authors: Wang Xing , He Yan , Wang Tao , Li Chunming , Ma Zihui , Zhang Heng , Ma Handong , Zhao Hongxin 
Published: January 2020

Purpose: This study aims to analyze the treatment patterns and goal attainment of low-density lipoprotein cholesterol (LDL-C) among patients with atherosclerotic cardiovascular disease (ASCVD) and diabetes mellitus (DM) in the real-world setting in Fuzhou, China. Methods: Patients aged ≥20 years with a valid LDL-C measurement (index date) in 2016 were selected from National Healthcare Big Data in Fuzhou, China. Patients were stratified into mutually exclusive cardiovascular risk categories: ASCVD (including recent acute coronary syndrome [ACS], chronic coronary heart disease [CHD], stroke, and peripheral arterial disease [PAD]), and DM alone (without ASCVD). Lipid-modifying medication and LDL-C attainment at the index date were assessed. Results: A total of 21 989 patients met the inclusion criteria, including 17 320 (78.8%) with ASCVD and 4669 (21.2%) with DM alone; 47.7% of patients received current statin therapy in the overall cohort (53.5% in ASCVD, 26.5% for DM); 20.5% ASCVD population achieved LDL-C target with the highest in patients with recent ACS (33.8%), followed by chronic CHD (21.2%), PAD (20.9%), and ischemic stroke (17.3%); 49.0% of patients with DM achieved LDL-C target. Higher LDL-C attainment was observed in high-intensity statin and a combination of statin and nonstatin groups. Atorvastatin was the most commonly used statin with the highest LDL-C attainment, followed by rosuvastatin. Conclusion: Compared with previous studies in China, our study found a relatively low statin use and LDL-C target attainment, but higher than similar studies in Europe. Guidelines should be well complied and more prescription of high-intensity statin or statin and nonstatin combination should be advocated.
Separation characterized by responsibility and guilt: Family caregivers’ experiences with palliative care for a close family member with severe dementia in long-term care facilities
Authors: Midtbust May H , Alnes Rigmor E , Gjengedal Eva , Lykkeslet Else 
Published: January 2020

Aim and objectives The aim of this study was to explore family caregivers’ experiences with palliative care for a close family member with severe dementia in long-term care facilities. Background Dementia not only affects individuals but also affects and changes the lives of close family members. An increasing number of dementia-related deaths occur in long-term care facilities; therefore, it is critical to understand how healthcare professionals support and care for residents with dementia and their families at the end of life. Design A qualitative design with a phenomenological approach was adopted. Methods In-depth interviews were performed with 10 family caregivers of residents in 3 Norwegian long-term care facilities. Results The family caregivers’ experiences with palliative care for a close family member with severe dementia in long-term care facilities were characterized by responsibility and guilt. Admission to a long-term care facility became a painful relief for the family caregivers due to their experiences with the poor quality of palliative care provided. The lack of meaningful activities and unsatisfactory pain relief enhanced the feelings of responsibility and guilt among the family caregivers. Despite the feelings of insecurity regarding the treatment and care given during the early phase of the stay, the family caregivers observed that their close family member received high-quality palliative care during the terminal phase. The family caregivers wanted to be involved in the care and treatment, but some felt that it became a heavy responsibility to participate in ethical decision-making concerning life-prolonging treatment. Conclusions The family caregivers experienced ongoing responsibility for their close family members due to painful experiences with the poor quality of the palliative care provided. When their expectations regarding the quality of care were not met, the palliative care that was offered increased their feeling of guilt in an already high-pressure situation characterized by mistrust.
Identifying Core Variables Associated With Health Literacy in Kidney Transplant Recipients
Authors: Dahl Kari Gire , Andersen Marit Helen , Urstad Kristin Hjorthaug , Falk Ragnhild S. , Engebretsen Eivind , Wahl Astrid Klopstad 
Published: January 2020

Background: A kidney transplantation requires complex self-care skills and adequate follow-up from health-care providers. Identifying strengths and limitations in different aspects of health literacy (HL) and associated variables are central to being able to improve health care. The objective of this study was to identify core variables associated with independent domains of HL 8 weeks following a kidney transplantation. Methods: A single-center cross-sectional study was conducted, wherein 159 kidney transplant recipients answered the Health Literacy Questionnaire (HLQ). Multivariable linear regression with backward elimination was used to investigate variables possibly associated with the 9 domains of HL. Results: The transplant recipients had the lowest scores in “appraisal of health information” and “navigating the healthcare system.” The highest scores were found in “feeling understood and supported by health-care providers” and “ability to actively engage with health-care provider.” General perceived self-efficacy, transplant-specific knowledge, and general health were the driving variables in several of the HL domains. Conclusions: The HLQ provides a more complex picture of strengths and limitations related to HL, as well as important knowledge about vulnerable groups following a kidney transplantation. The study offers an important supplement to the field of HL in kidney transplant care.