bluuebunny/crossref_metadata_2025_split huggingface dataset:
Duration of untreated eating disorder and relationship to outcomes: A systematic review of the literature
Authors: Austin Amelia , Flynn Michaela , Richards Katie , Hodsoll John , Duarte Tiago Antunes , Robinson Paul , Kelly Jonathan , Schmidt Ulrike 
Published: June 2020

AbstractObjectiveThis systematic review assesses the average duration of untreated eating disorder (DUED) in help‐seeking populations at the time of first eating disorder (ED) treatment and investigates the relationship between DUED and symptom severity/clinical outcomes.MethodPRISMA guidelines were followed throughout. Selected studies provided information on either: (i) length of DUED, (ii) components of DUED, (iii) cross‐sectional associations between DUED and symptom severity, (iv) associations between DUED and clinical outcomes, or (v) experimental manipulation of DUED. Study quality was assessed.ResultsFourteen studies from seven countries were included. Across studies, average DUED weighted by sample size was 29.9 months for anorexia nervosa, 53.0 months for bulimia nervosa and 67.4 months for binge eating disorder. A younger age at time of first treatment was indicative of shorter DUED. Retrospective studies suggest that a shorter DUED may be related to a greater likelihood of remission. Manipulation of DUED by shortening service‐related delays may improve clinical outcomes.ConclusionsData on length of DUED provide a benchmark for early intervention in EDs. Preliminary evidence suggests DUED may be a modifiable factor influencing outcomes in EDs. To accurately determine the role of DUED, definition and measurement must be uniformly operationalised.Highlights
This systematic review is the first to examine duration of untreated eating disorder (DUED) across different eating disorders. Definitions and measurement of DUED and its components vary considerably between studies.
Across different eating disorders average DUED weighted by sample size ranges from approximately two and a half years (for anorexia nervosa) to nearly 6 years (for binge eating disorder).
DUED appears to be related to age such that younger patients have shorter DUED.
The effects of mentor alcohol use norms on mentorship quality: The moderating role of protégé traditionality
Authors: Kwan Ho Kwong , Chen Haixiao , Hu Zhonghui , Li Jinsong 
Published: June 2020

AbstractMentorship quality is an important aspect of mentorship effectiveness, yet we know little about its predictors. Using social identity theory, we examined the relationship between mentor alcohol use norms and mentorship quality as perceived by protégés. Our study also considered the mediating role of protégé identification with the mentor and the moderating role of protégé traditionality. The findings, based on mentor‐protégé dyadic data collected through a three‐wave survey in China, indicate that mentor alcohol use norms are negatively related to mentorship quality, and that this relationship is mediated by protégé identification with the mentor. Furthermore, the traditionality of protégés alleviates not only the negative relationship between mentor alcohol use norms and protégé identification with the mentor, but also the indirect relationship between mentor alcohol use norms and mentorship quality via protégé identification with the mentor. The results underscore the value of focusing on mentor behavioral norms that are not directed toward the protégé. We conclude with a discussion of the theoretical and practical implications for mentoring research.
An analysis of the corporate insolvency resolution process as a route for acquisitions in India
Authors: Handa Ankit 
Published: June 2020

AbstractIn India, the Corporate Insolvency Resolution Process (“CIRP”) takes place under the Insolvency and Bankruptcy Code, 2016 (“IBC”). It involves a Resolution Professional inviting resolution plans for the corporate debtor undergoing insolvency. These plans are submitted by various Resolution Applicants and the best resolution plan is approved by the Committee of Creditors and sanctioned by the National Company Law Tribunal. Thus, from an acquisition perspective, the potential acquirer of the stressed asset is required to provide the best bid (in the form of the resolution plan) for the stressed asset which would be able to garner the approval of the Committee of Creditors. The CIRP route has led to successful acquisitions across variegated sectors from steel (Essar Steel) to textiles (Alok Industries) and has become a new and effective tool to undertake acquisitions for prospective acquirers providing a simpler and faster way for acquisition of stressed assets. However, acquisitions through this process are not yet free from their imperfections and there are certain problems, which if addressed, could pave a way for fruitful investments in the Indian economy. This would bolster an investment and acquisition friendly regime in India improving our nation's ranking on the ease of doing business index even further. This article seeks to analyse CIRP as an effective route for acquisitions and identify such problems which are relevant from an acquisition perspective, with the objective and hope that a discussion on these issues can help strengthen and stimulate successful acquisitions and investments in the Indian economy.
A snapshot of company voluntary arrangements: Success, failure and proposals for reform
Authors: Walton Peter , Umfreville Chris , Jacobs Lézelle 
Published: June 2020

AbstractCompany Voluntary Arrangements (CVAs) are designed to be used in the UK to rescue a company as a going concern. They are under used in practice and have a reputation for high failure rates. This article, based upon a longer report funded by the UK insolvency profession, considers the nature of success or failure of CVAs. It considers empirical evidence to identify the weak points of CVAs in practice. It looks at quantitative data as well as taking into account views of practitioners and other stakeholders. Key elements of the CVA procedure are considered in light of recent national reform proposals and approaches and reforms internationally. Domestic reforms in the Netherlands and South Africa are considered to determine whether any lessons might be learnt from other jurisdictions. Recommendations are made including changes to the suggested amendments to the legal framework and to professional practice guidance.
Loss of efficacy of subsequent nonsurgical therapy after primary treatment failure in pediatric low‐grade glioma patients—Report from the German SIOP‐LGG 2004 cohort
Authors: Kandels Daniela , Pietsch Torsten , Bison Brigitte , Warmuth‐Metz Monika , Thomale Ulrich‐Wilhelm , Kortmann Rolf‐Dieter , Timmermann Beate , Hernáiz Driever Pablo , Witt Olaf , Schmidt René , Gnekow Astrid K. 
Published: June 2020

AbstractFirst‐line treatment of pediatric low‐grade glioma using surgery, radio‐ or chemotherapy fails in a relevant proportion of patients. We analyzed efficacy of subsequent surgical and nonsurgical therapies of the German cohort of the SIOP‐LGG 2004 study (2004‐2012, 1558 registered patients; median age at diagnosis 7.6 years, median observation time 9.2 years, overall survival 98%/96% at 5/10 years, 15% neurofibromatosis type 1 [NF1]). During follow‐up, 1078/1558 patients remained observed without (n = 217), with 1 (n = 707), 2 (n = 124) or 3 to 6 (n = 30) tumor volume reductions; 480/1558 had 1 (n = 332), 2 (n = 80), 3 or more (n = 68) nonsurgical treatment‐lines, accompanied by up to 4 tumor‐reductive surgeries in 215/480; 265/480 patients never underwent any neurosurgical tumor volume reduction (163/265 optic pathway glioma). Patients with progressing tumors after first‐line adjuvant treatment were at increased risk of suffering further progressions. Risk factors were young age (<1 year) at start of treatment, tumor dissemination or progression within 18 months after start of chemotherapy. Progression‐free survival rates declined with subsequent treatment‐lines, yet remaining higher for patients with NF1. In non‐NF1‐associated tumors, vinblastine monotherapy vs platinum‐based chemotherapy was noticeably less effective when used as second‐line treatment. Yet, for the entire cohort, results did not favor a certain sequence of specific treatment options. Rather, all can be aligned as a portfolio of choices which need careful balancing of risks and benefits. Future molecular data may predict long‐term tumor biology.
Conformers of dehydrogenated glycine isomers
Authors: Orján Erik M. , Nacsa András B. , Czakó Gábor 
Published: June 2020

AbstractWe report a comprehensive ab initio investigation of the conformers of dehydrogenated glycine radicals using the STO‐3G, 3‐21G, and aug‐cc‐pVDZ (aVDZ) basis sets and the UHF and UMP2 (H2N‐CH‐COOH and HN‐CH2‐COOH) as well as MCSCF and MRCI (H2N‐CH2‐COO) methods via two different conformational search strategies generating initial structures for optimizations by (a) removing H atoms from glycine conformers and (b) scanning torsional angles describing internal rotation along the CC, CN, and CO (except for H2N‐CH2‐COO) bonds of the radicals. We find four H2N‐CH‐COOH {InCH, IInCH, IIInCH, IVnCH} and seven HN‐CH2‐COOH {IpNH, IIpNH, IIInNH, IVpNH VnNH, VIpNH, VIIpNH} conformers with classical(adiabatic) relative energies of {0.00(0.00), 1.57(1.55), 5.25(5.03), 9.85(9.72)} and {0.00(0.00), 0.78(1.06), 1.93(2.08), 3.34(3.16), 3.39(3.29), 5.00(4.86), 9.27(8.87)} kcal/mol, respectively, obtained with UCCSD(T)‐F12b/aug‐cc‐pVTZ(+UCCSD(T)‐F12b/aVDZ ZPE correction) and four H2N‐CH2‐COO {IpCOO, IInCOO, IIIpCOO, IVnCOO} conformers with MRCI‐F12+Q/aVDZ(+MRCI/aVDZ ZPE correction) energies of {0.00(0.00), 1.65(1.64), 1.78(1.75), 2.21(2.21)} kcal/mol, where n and p denote C1 and Cs symmetry. The MRCI‐F12+Q[UCCSD(T)‐F12b] InCH → IpNH and InCH → IpCOO classical(adiabatic) isomerization energies are 18.51(17.32)[21.20(20.01)] and 31.88(31.66) kcal/mol, respectively.
The stakes of self‐worth: Examining contingencies of self‐worth to clarify the association between global self‐esteem and eating disturbances in college women
Authors: Chang Olivia D. 
Published: June 2020

AbstractObjectiveThe present study tested a hypothesized mediation model in which the seven contingencies of self‐worth proposed by Crocker and Wolfe mediate the association between global self‐esteem and eating disturbances in college women.MethodThis study utilized a sample of 408 college women. Path analysis was used to produce a model in which the association between global self‐esteem and eating disturbances was accounted for through contingencies of self‐worth.ResultsThe finalized model indicated that self‐worth based on appearance and competition mediated the link between global self‐esteem and both drive for thinness and bulimic symptoms. Self‐worth based on virtue mediated the link between global self‐esteem and bulimic symptoms.ConclusionThe present findings clarify facets of self‐worth accounting for the association between global self‐esteem and eating disturbances in college women, and point to how self‐worth based on one's appearance, or the ability to outdo others, is centrally implicated in this relationship.
Collective action among US veterans: Understanding the importance of self‐efficacy, collective efficacy, and social support
Authors: Matthieu Monica M. , Carbone Jason T. 
Published: June 2020

AbstractThe purpose of this study was to examine the relationship between collective action, collective efficacy, self‐efficacy, and social support among US veterans who formally volunteered in their communities upon their return from military service. The participants were 323 post‐9/11/01‐era veterans who completed a national nonprofit administered civic service program. Results from the structural equation model indicate that appraisal social support is negatively, directly associated with collective action, while belonging social support is positively, directly associated with collective action. In addition, appraisal social support is positively, indirectly associated with collective action via self‐efficacy and collective efficacy. About 44% of the relationship between self‐efficacy and collective action is associated via collective efficacy. The model accounts 19.9% of the variance in self‐efficacy, 16.5% of the variance in collective efficacy, and 23.7% of the variance in collective action. The role of social support in the model provides additional evidence for the importance of strong social ties in facilitating collective action as veterans gather to volunteer in programs across the country. Results have implications for how national, nonprofit, and community volunteering programs may want to engage veterans and community members in collective action efforts.
Examining contextual and relational factors influencing perceptions of societal and interpersonal mattering among rural youth
Authors: Schmidt Carissa J. , Stoddard Sarah A. , Heinze Justin E. , Caldwell Cleopatra H. , Zimmerman Marc A. 
Published: June 2020

AbstractResearchers have shown that interpersonal and societal mattering have important implications for adolescent development. Yet, few researchers have focused on what predicts mattering, particularly societal mattering, and even fewer have studied mattering among rural youth. Thus, the purpose of this study is to explore how perceived contextual and relationship factors affect rural youths’ perceptions of societal and interpersonal mattering. Participants for this study were 381 middle school youth from two rural school districts in Michigan. Using structural equation modeling, we found that more positive perceptions regarding opportunities for youth involvement, availability of community resources, student input in decision‐making at school, and support for autonomy at school were associated with greater perceptions of societal mattering. In addition, greater support from friends, higher quality parent–child communication, and more parental involvement were associated with a greater sense of interpersonal mattering. This study identifies important relational and contextual factors that can be enhanced in an effort to foster greater perceptions of interpersonal and societal mattering among rural youth, and ultimately help us to promote positive youth development.
The Effect of GS‐548351 on the Pharmacokinetics of Midazolam Following Multiple Doses of ANS‐6637 in Healthy Adults
Authors: Bunn Haden T. , Rosenthal Elana , Mathur Poonam , McLaughlin Mary , Proschan Michael , Vijan Arjun , Aepfelbacher Julia , Kottilil Shyamasundaran , Masur Henry , Kattakuzhy Sarah , George Jomy M. 
Published: June 2020

AbstractANS‐6637, a pro‐drug of GS‐548351, is a selective, reversible inhibitor of aldehyde dehydrogenase isoform 2 under development as an anticraving agent for the treatment of substance use disorders. In vitro testing indicates that GS‐548351 is an inhibitor and inducer of cytochrome P450 family 3, subfamily A (CYP3A). In this phase 1 single‐center, open‐label, fixed‐sequence drug‐drug interaction study we assessed the impact of steady‐state GS‐548351 on single‐dose pharmacokinetics of midazolam, an index substrate for CYP3A. Twelve healthy volunteers received 600 mg of ANS‐6637 by mouth daily from study days 3 to 8 and a single 5‐mg oral dose of midazolam on days 1 and 8. Pharmacokinetic samples were collected over 24 hours on days 1 and 8, then analyzed using liquid chromatography‐tandem mass spectrometry. The prespecified no‐effect range for the 90% confidence interval (CI) of the geometric mean ratio (GMR) of midazolam coadministered with ANS‐6637 (day 8) compared with midazolam alone (day 1) was 0.7‐1.43. There was an increase in midazolam AUC0‐∞ (GMR [90%CI]) that was within the no‐effect range (1.26 [1.12‐1.425]) and an increase in midazolam Cmax that was outside the range (1.22 [1.03‐1.45]). The AUC0‐∞ (1.08 [0.91‐1.27]) and Cmax (0.95 [0.75‐1.2]) of 1‐hydroxymidazolam, the primary metabolite of midazolam, were also within the no‐effect range. A single grade 3 adverse event (alanine aminotransferase elevation) was identified and resolved following discontinuation of the study drug. Overall, multidose ANS‐6637 was well tolerated and did not alter the PK of midazolam beyond a small increase in AUC0‐∞ that is unlikely to be clinically significant.
Losses of selected pesticides in drainage water from containerized ornamental plants
Authors: Hinz Francisca Ordonez , van Santen Edzard , Fisher Paul R. , Wilson P. Chris 
Published: June 2020

AbstractLimited research has focused on factors affecting pesticide losses from ornamental plant production nurseries. This project evaluated the effects of overhead irrigation or simulated rainfall intensity and formulation and application methods on the losses of acephate, bifenthrin, and imidacloprid in drainage water. The liquid formulation of each respective pesticide was applied to individual replicates (potted Ilex cornuta Lindl. & Paxton plant on a drainage collection saucer) as substrate‐applied drenches or foliar sprays (acephate and bifenthrin only). Granular formulations of acephate and imidacloprid were spread across the tops of media in pots. After application of treatments, irrigation or simulated rainfall was applied daily for 19 consecutive days at rates of 42.3 ± 4.57, 56.7 ± 7.92, and 95.4 ± 19.47 ml min−1, and drainage water from individual replicates was collected for analysis. Irrigation or simulated rainfall intensity had no effects on losses of the pesticides under the conditions tested. Concentrations in drainage of all three pesticides were highest from the drench applications, whereas respective foliar spray applications resulted in the lowest active ingredient concentrations in drainage. The percentage of active ingredient lost in drainage water ranged from a minimum of 0.2 ± 0.05% (mean ± SE) for granular acephate to a maximum of 19.5 ± 3.14% (mean ± SE) for the imidacloprid drench. Most pesticide losses occurred within the first 2 d after application of drenches or sprays. Granular formulations had a longer period of release, indicating a risk of loss from overirrigation during an extended period. Results emphasize the need for careful water management after applications.
The experience of Preimplantation Genetic Testing (PGT) among Muslim couples in Oman in the Middle East
Authors: Al‐Kharusi Khalsa , Bruwer Zandre , Wessels Tina‐Marié 
Published: June 2020

AbstractPreimplantation genetic testing (PGT) is an alternative reproductive technology integrated with in vitro fertilization (IVF). It is a well‐established technique offering a reproductive option for families at a high risk of transmitting a genetic disorder, allowing them to avoid making a decision about termination of an affected pregnancy (TOP). In Arab communities and particularly in Oman, where TOP is not favored under the majority of implemented Muslim law, termination of pregnancy for fetal indications is not always possible. As these communities are in favor of consanguineous marriage, they are at increased risk of serious and lethal autosomal recessive conditions, and as a result, PGT is a feasible option as a TOP decision can be avoided. However, undergoing PGT is relatively new in the Arab Muslim countries and Omani patients have only recently had access to the service. This qualitative study utilized a phenomenological approach to explore the experience of Omani families who had selected to undergo PGT as a means of reducing the risk of having a child affected with a genetic disorder. Fourteen participants from eight families who underwent PGT were interviewed. Data collected were analyzed using thematic analysis. The research identified four main themes: Anxiously waiting ‘Taraqub’; Unforeseen; Secrecy; and Me and My Partner. The findings of the research have provided insight into the PGT experiences of Omani families. Unique cultural and religious perspectives should be considered when counseling Omani Muslim couples.
Who we are, what we do, and how we add value: The role of the genetic counseling ‘philosophy of practice’ statement in a changing time
Authors: McEwen Alison , Jacobs Chris 
Published: June 2020

AbstractAs genetics and genomics are integrated into health care and non‐genetic health professionals deliver aspects of genetic counseling, it is increasingly important for genetic counselors to be able to define who we are, what we do, and how we add value to client interactions, both on an individual and professional basis. In this paper, we argue that to understand ourselves as individual practitioners and as a profession, we each need to reflect on, write, and constantly review our own philosophy of practice. A philosophy of practice is a dynamic, personal, and reflective statement or narrative that captures the core ideas, values, and beliefs of the individual about their chosen profession, including concrete examples of what this involves in practice. Here, we consider the nature, purpose, and relevance of a philosophy of genetic counseling practice, drawing on examples from professions such as teaching and nursing, where the exercise of writing a philosophy of practice is more established. We demonstrate how and why we have introduced writing a philosophy of practice into our Master of Genetic Counseling program at University of Technology Sydney and consider the possibilities for introducing such practice into professional registration or certification processes. Finally, we offer our own philosophy of genetic counseling practice as an example. As the roles and scope of practice for genetic counselors expand and diversify, it is increasingly important to understand, own, and retain our core values and principles as individual practitioners and as a profession. Ensuring client‐centered practice remains at the heart of genetic health care is vital. We encourage all genetic counselors to write, publish, and share their philosophy of practice, adding to our collective professional identity in this time of change and opportunity.
A modified rider optimization algorithm for multihop routing in WSN
Authors: Augustine Susan , Ananth J.P. 
Published: June 2020

AbstractWireless Sensor Networks (WSNs) have an important role in establishing the communication between the Internet of things (IoT) devices. Routing is an important research field in the WSN as it helps in finding the suitable paths for the communication. This paper proposes a multipath routing algorithm based on the optimization approach. The proposed routing algorithm has two important phases, namely, Cluster head selection and multipath routing. Initially, the cluster head selection is carried out by the kernel based Fuzzy C Means (kernel FCM) algorithm. Then, the multipath routing is established by the newly developed Rider Salp Swarm Optimization algorithm (RSSA), which is the integration of the Rider Optimization Algorithm (ROA) and Salp Swarm Algorithm (SSA). The fitness function of the proposed RSSA is designed by considering the several factors, such as energy, QoS and trust. The simulation of the proposed work is carried out using different WSN setups, and the results are compared with several comparative techniques. From the results, it can be summarized that the proposed RSSA based multipath routing has better performance with values of 0.2526, 0.0764, 0.5, and 26 for delay, energy, throughput and number of alive nodes, respectively.