bluuebunny/crossref_metadata_2025_split huggingface dataset:
Passing across the blood-brain barrier in glioblastoma multiforme (GBM)
Authors: Rocka Agata , Psiuk Dominika , Nowak Emilia , Madras Dominika , Szumna Klaudia 
Published: October 2020

Introduction and purpose: Blood-brain barrier (BBB) consists of capillary endothelium, in which there are three types of intercellular junctions - adherent, tight and gap junctions.Efficient therapy involves delivering a therapeutic dose of drug into a specific site in the body, and maintaining this dose for adequate time afterwards. The aim of this study is to review current knowledge of new strategies in drug delivery to CNS and the effectiveness of these methods in glioblastoma multiforme (GBM) treatment. This review was performed using the PubMed database. A brief description of the state of knowledge: Methods for delivering drugs to the brain are divided into invasive and non-invasive. Invasive methods involve temporary disrupting tight intercellular junctions of the vascular endothelial cells and delivering drugs intracerebrally or intraventricularly during neurosurgical procedures. In recent years, there has been a growing interest in the use of nanoparticles as drug carriers to the central nervous system via blood-brain barrier. The usage of nanoparticles implies many advantages, such as non-invasive, low cost, good biodegradability, stability, ability to carry various types of agents, selectivity and ability to control drug release. Conclusions: Limited options in treating brain located tumors, including glioblastoma multiforme, due to difficulties in drug penetration through the BBB engages scientists to search for new treatments. Crossing the BBB using invasive methods based on interruption of cell junctions show promising results, but they are associated with i.a. a high risk of uncontrolled influx of toxins to the CNS or ion-electrolyte imbalance, which may lead to neuronal dysfunction. Invasive methods can be effective only in tumors, while treatment of diseases such as Alzheimer’s disease is impossible. Recent studies show that nanoparticles would be a great, non-invasive alternative, but they are difficult to use with relatively low permeability through undamaged BBB. In some studies using nanoparticles as nanocarriers (EDVDox) or SYMPHONY method (combining photothermal therapy with GNS and immunotherapy of checkpoints in a mouse model) against GBM shows positive results. More research is required to confirm the effectiveness and safety of these treatments.
Encoding technology of an asymmetric combined structured light for 3D measurement
Authors: Cao Zhirui , Jiang Hanbing 
Published: October 2020

Sinusoidal phase-shifting symmetrically combined with cyclic code is
one of the most important encoding methods in the field of 3D
measurement. Due to the modulation of the object surface and the
influence of the noise of the image acquisition system, the periods of
the cyclic code and the sinusoidal phase-shifting in the intensity
image do not coincide completely, and they lead to large absolute
phase decoding errors near the cycle boundaries, which are called
cycle dislocation errors. In order to eliminate these errors in
principle, the concept and method of region encoding for four-step
sinusoidal phase-shifting are proposed, and the sinusoidal
phase-shifting is combined with cyclic code asymmetrically. Under the
premise that the cyclic code and the region code change at different
times, the cycle dislocation error is reduced from one cycle of cyclic
code to one pixel by the dual constraint of cyclic code and region
code. The simulation measurement results of 3 ds max and the
physical measurement results show that the asymmetric combination
encoding method effectively eliminates the cycle dislocation errors;
the maximum measurement error is reduced by an order of magnitude, and
the root mean square measurement error is reduced by 70%.
Design New Compound of Meisoindigo Derivative as Anti Breast Cancer Based on QSAR Approach
Authors: Ananto Agus Dwi , Muliasari Handa , Hadisaputra Saprizal 
Published: October 2020

Design new compounds of Meisoindigo using the QSAR approach with semiempirical methods have been successfully made with better biological activity as anti-breast cancer results. The research method used to design the new compound of meisoindigo derivatives uses the semiempirical methods. The research procedure divide into tree step, molecular modeling, QSAR equation analysis, and design of new compounds. The PM3 method was chosen as a better method because it has model results that are more representative of physicochemical aspects. The selection of the best model is made by multilinear regression statistical analysis. New compounds derived from the design are expected to bind to the Cyclin-Dependent Kinase 4 (CDK4) enzyme that helps in the cell cycle to prevent cell division. Based on the design, the compound of (E)-2-(2-oxo-1-(2-(trifluoromethyl) benzyl)indolin-3-ylidene)-N-(quinoline-7-yl) acetamide choose as a new compound with more better biological activity (log 1/IC50 = 6.992) than before (log 1/IC50 = 5.823)
Determination of Shelf Life of Herbal Products from the Combination of Stevia rebaudiana, Curcuma zanthorrhiza and Honey (Stekurmin MD) through the Accelerated Shelf Life Test (ASLT) Method
Authors: Martono Yohanes , Novitasari Fidelia , Aminu November Rianto 
Published: October 2020

Stekurmin MD is a syrup preparation formulated from the extract of Stevia rebaudiana leaves, temu lawak (Curcuma zanthorrhiza), and honey. One of the active compounds in Stekurmin MD products is phenolic and flavonoid compounds in which the active phenolic and flavonoid compounds can be degraded during the storage period. This study aimed to determine the shelf life of Stekurmin MD products based on the degradation of phenolic compounds and flavonoids. The Accelerated Shelf Life Test (ASLT) method was used in determining the shelf life kinetics of this product. Phenolic and flavonoid concentrations were determined using the UV-Vis spectrophotometric method with the gallic acid standard for phenolic and quercetin standard for flavonoids. Degradation of phenolic and flavonoid compounds was determined every 7 days during 35 days of storage at 25, 35, 45, and 55°C ± 2°C. In natural ingredients, there is a multi-mechanism reaction. The shelf life of Stekurmin MD products based on the degradation of phenolic and flavonoid active ingredients at room temperature were 39.909 days and 23.53 hours, respectively.
Does the Activity in Scapular Muscles During Plyometric Exercises Change When the Kinetic Chain Is Challenged?—An EMG Study
Authors: Werin Maria B. , Maenhout Annelies G. , Icket Jonas , Jacxsens Nielt , Kempkes Evelien , Cools Ann M. 
Published: October 2020

Abstract
Werin, MB, Maenhout, AG, Icket, J, Jacxsens, N, Kempkes, E, and Cools, AM. Does the activity in scapular muscles during plyometric exercises change when the kinetic chain is challenged?—An EMG study. J Strength Cond Res 36(7): 1793–1800, 2022—Plyometric exercises for the shoulder are used in rehabilitation and in workout regime when the sport demands high speed power training. The aim of this clinical laboratory electromyography (EMG) study was to determine whether scapular muscle performance differs during plyometric shoulder exercises when changing the demand on the kinetic chain. Thirty healthy overhead athletes, with a mean age of 22.7 years (±2.2), performed 6 exercises, with both a low and a high demand on the kinetic chain, in prone, side and standing in positions. The EMG activity of the upper trapezius (UT), middle trapezius (MT), lower trapezius (LT), and serratus anterior (SA) on the tested side and bilateral of gluteus maximus (GM) and abdominal oblique externus (OE) was registered with wireless surface EMG. Intermuscular muscle ratios UT/SA, UT/MT, and UT/LT were also calculated. The level of significance set for the study was alpha = 0.05. The muscle ratio UT/SA was significantly lower (p < 0.05) when high demand on the kinetic chain compared with low. SA muscle activity showed significantly (<0.001) higher values in the prone position with high demand on the kinetic chain compared with low. All 3 trapezius muscle parts had significantly higher values (p < 0.001) in the prone compared with side and standing positions. The GM and OE showed significantly higher (p ≤ 0.01) activity in positions more demanding for the kinetic chain. When composing a strengthening or a rehabilitation program for athletes, the knowledge of how scapular and trunk muscles interact can be used to amplify the strengthening effect.
Wearing Compression Garment Enhances Central Hemodynamics? A Systematic Review and Meta-Analysis
Authors: Lee Daniel C.W. , Ali Ajmol , Sheridan Sinead , Chan Derwin K.C. , Wong Stephen H.S. 
Published: October 2020

Abstract
Lee, DCW, Ali, A, Sheridan, S, Chan, DKC, and Wong, SHS. Wearing compression garment enhances central hemodynamics? a systematic review and meta-analysis. J Strength Cond Res 36(8): 2349–2359, 2022—Compression garments (CG) are believed to enhance exercise performance and recovery by improving central hemodynamic responses. However, evidence is inconclusive. We performed a systematic review and meta-analysis to determine the effect of wearing CG at rest or after a physiological challenge on central hemodynamic responses, including cardiac output, stroke volume (SV), heart rate (HR), systolic blood pressure, diastolic blood pressure (DBP), and systemic vascular resistance in healthy individuals. The English language searches of the electronic databases SPORTDiscus, MEDLINE, and Web of Science were conducted from November 2018–February 2019. The studies involved were limited to the following: (a) original articles; (b) randomized controlled trials; (c) monitoring of central hemodynamic responses (either at rest or after a physiological challenge: maximal exercise or orthostatic challenge); and (d) healthy individuals. Of the 786 studies identified, 12 were included in the systematic review and meta-analysis. Meta-analysis was performed by the restricted maximum likelihood method. The results indicated that the effect size (ES) of wearing CG on improving central hemodynamic responses was large overall (Hedges' g = 0.55) and was large in SV (Hedges' g = 1.09) and HR (Hedges' g = 0.65). Subgroup analysis showed that the ESs in “post-physiological challenge” was large in overall (Hedges' g = 0.98), SV (Hedges' g = 1.78), HR (Hedges' g = 1.10), and DBP (Hedges' g = 0.75). Their ESs in “at rest” were not significant in all central hemodynamic responses, apart from a significant medium ES observed in SV (Hedges' g = 0.44). Healthy individuals who wear CG have marked improvement in central hemodynamic responses, particularly after a physiological challenge. More pronounced effects of CG are observed in increasing SV and reducing HR.
Effects of Combined Strength and Resisted Sprint Training on Physical Performance in U-19 Elite Soccer Players
Authors: Ben Brahim Mehdi , Bougatfa Rim , Makni Emna , Gonzalez Pablo Prieto , Yasin Hussain , Tarwneh Raghad , Moalla Wassim , Elloumi Mohamed 
Published: October 2020

Abstract
Ben Brahim, M, Bougatfa, R, Makni, E, Gonzalez, PP, Yasin, H, Tarwneh, R, Moalla, W, and Elloumi, M. Effects of combined strength and resisted sprint training on physical performance in U-19 elite soccer players. J Strength Cond Res 35(12): 3432–3439, 2021—This study assessed the effects of combined muscular strength and resisted sprint training using both sled and weight vest compared with regular soccer training on physical fitness of lower limbs in U-19 elite soccer players. Thirty-four male soccer players (age: 18.8 ± 0.8 years, height: 1.81 ± 0.05 m, body mass: 76.4 ± 4.9 kg, and body fat mass: 11.3 ± 4.2%) were randomly assigned into a resisted sprint training group (RSTG, n = 20), using both weight vest and sled, and a control group (CONTG, n = 14). Sprinting ability (5 m and 20 m), squat jump (SJ) and counter-movement jump (CMJ) tests, 1 repetition maximum of half-back squat (1RM half-back squat), and soccer ball-shooting speed were assessed before and after a 6-week training program. Within-group interactions showed significant combined muscular strength and resisted sprint training effects were observed for all the tests' measurements (effect sizes = 0.97 and 3.69 for 20-m sprint and SJ, respectively). However, significant increases of performances were observed for 5-m and 20-m sprinting time (

= 0.25, p < 0.01 and

= 0.22, p < 0.01, respectively), SJ and CMJ (

= 0.78, p < 0.0001 and

= 0.34, p < 0.001, respectively), 1 repetition maximum (1-RM) half-back squat (

= 0.45, p < 0.0001), and soccer ball-shooting speed (

= 0.41, p < 0.0001) in RSTG with large effect size, whereas the CONTG showed significant performances increase only for CMJ (p < 0.05), 1RM half-back squat (p < 0.01), and soccer ball-shooting speed (p < 0.05). We conclude that combined strength and both horizontal (weighted sled) and vertical (weighted vest) resisted sprint training are more effective than regular soccer training for enhancing sprinting and jumping abilities as well as ball-shooting speed in soccer.
Changes in Loaded Countermovement Jumps During Precompetition and Competition Training Mesocycles in Elite Rowers
Authors: Everett Kirsten L.A. , Chapman Dale W. , Mitchell John A. , Ball Nick 
Published: October 2020

Abstract
Everett, KLA, Chapman, DW, Mitchell, JA, and Ball, N. Changes in loaded countermovement jumps during precompetition and competition training mesocycles in elite rowers. J Strength Cond Res 36(9): 2622–2627, 2022—To assess changes in velocity, displacement, and power as an indicator of neuromuscular fatigue (NMF) within and between precompetition and competition mesocycles in elite male rowers using loaded countermovement jumps (CMJs). Twenty highly trained rowers completed regular training (on-water rowing, rowing ergometer, and resistance training sessions) in 2 consecutive mesocycles. Athletes completed a single set of 6 loaded (20 kg) CMJs in the first and final week of each mesocycle. Countermovement jumps were assessed for jump height (JH), eccentric displacement, mean velocity (MV), eccentric MV (EMV), and mean power. Changes between time points were reported as Cohen's d effect sizes (95% confidence interval [CI]). The magnitude of the differences was also considered based on their relative strength levels using a linear mixed model. Within the precompetition mesocycle, trivial-to-small reductions for all variables (0.5–4.1%) were observed. During the competition mesocycle, trivial-to-small increases were shown for EMV (1.4%) and eccentric displacement (2.0%) with no change in JH and small reductions in MV (0.5%) and mean power (2.8%). No differences between the precompetition and competition mesocycles were shown. Only mean power showed a significant reduction in weaker athletes (3.2%) compared with stronger athletes (2.3%). Training completed during a precompetition and competitive mesocycle did not result in significant decreases in athlete's loaded CMJ performance, indicating that NMF was minimized. Alternatively, use of a loaded CMJ may not be sensitive enough to observe NMF in elite rowers during the mesocycle immediately leading into and during a competition mesocycle.
Compression Socks Reduce Running-Induced Intestinal Damage
Authors: Zadow Emma K. , Edwards Kate H. , Kitic Cecilia M. , Fell James W. , Adams Murray J. , Singh Indu , Kundur Avinash , Johnston Amy N.B. , Crilly Julia , Bulmer Andrew C. , Halson Shona L. , Wu Sam S.X. 
Published: October 2020

Abstract
Zadow, EK, Edwards, KH, Kitic, CM, Fell, JW, Adams, MJ, Singh, I, Kundur, A, Johnstone, ANB, Crilly, J, Bulmer, AC, Halson, SL, and, and Wu, SSX. Compression socks reduce running-induced intestinal damage. J Strength Cond Res 36(9): 2461–2464, 2022—Exercise is associated with a reduction in splanchnic blood flow that leads to the disruption of intestinal epithelium integrity, contributing to exercise-induced gastrointestinal syndrome. Strategies that promote intestinal blood flow during exercise may reduce intestinal damage, which may be advantageous for subsequent recovery and performance. This study aimed to explore if exercise-associated intestinal damage was influenced by wearing compression garments, which may improve central blood flow. Subjects were randomly allocated to wear compression socks (n = 23) or no compression socks (control, n = 23) during a marathon race. Blood samples were collected 24 hours before and immediately after marathon and analyzed for intestinal fatty acid–binding protein (I-FABP) concentration as a marker of intestinal damage. The magnitude of increase in postmarathon plasma I-FABP concentration was significantly greater in control group (107%; 95% confidence interval [CI], 72–428%) when compared with runners wearing compression socks (38%; 95% CI, 20–120%; p = 0.046; d = 0.59). Wearing compression socks during a marathon run reduced exercise-associated intestinal damage. Compression socks may prove an effective strategy to minimize the intestinal damage component of exercise-induced gastrointestinal syndrome.
Evaluating the effect of inpatient diabetes education on length of stay, readmission rates and mortality rates: a systematic review
Authors: Hussain Zeeshan , Alkharaiji Mohammed , Idris Iskandar 
Published: October 2020

Background: Hospitalised patients with diabetes experience a longer duration of inpatient stay, increased readmission rates and excess mortality compared with patients without diabetes.Objectives: To determine whether inpatient diabetes education (IDE), provided to hospitalised patients with diabetes, is an effective intervention in improving one or all of the following clinical outcomes: length of stay (LOS), readmission rate and mortality rate.Methods: A free-text search on MEDLINE, PubMed, CINAHL, BNI and EMBASE was conducted on literature published from the date of each databases’ inception to March 2019. In addition, grey literature was used to support the search with the following key terms: ‘IDE’, ‘LOS’, ‘readmission’ and ‘mortality’, along with their possible substitutes and alternatives combined.Results: In total, eight studies met the inclusion criteria with a total number of 3,828 participants. Seven studies investigated LOS outcome for which accumulated mean LOS and median LOS were both lower (16.5% and 26.67%, respectively) in the IDE group compared with the non-IDE group. Six studies investigated readmittance rates, for which accumulated readmission rate (up to 12 months) was 15.9% lower in the IDE group than in the non-IDE group. Finally, the mortality rate was 36.6% lower in the IDE group compared with the non-IDE group, but this was non-significant and only one study reported this outcome.Conclusion: The findings of this review support the efficacy of an IDE programme in a hospital setting by reducing LOS and readmission rates in patients with diabetes. In addition, a possible trend towards a decreased mortality rate was observed. IDE is therefore recommended to improve clinical outcomes of hospitalised patients with diabetes.
La gestión del infoconocimiento en instituciones de educación superior
Authors: Alba Cabañas Marisleidy , Gutiérrez de Piñeres Botero Liliana 
Published: October 2020

Las instituciones de educación superior muestran algunas debilidades y problemáticas en los procedimientos, la protección y evaluación de la información; en las formas para evitar la pérdida, difusión de información sensible, y en la conservación del conocimiento. A esto se suma la obligación de responder a los planes de mejoramiento, a los nuevos sistemas de información, a eliminar la burocracia, las duplicidades y a eliminar errores y pérdidas de información. Estas son las dificultades que han llevado a intervenir la gestión de procesos de estas instituciones.
Siguiendo las tipologías de consultoría gerencial, a través de una metodología de diagnóstico se estudiaron los procesos, los puntos críticos, la gestión de la información y el estado del proceso de gestión del conocimiento. El resultado de esta mejora permite construir un modelo de gestión del infoconocimiento, así como un procedimiento en el que se identifican los pasos para desarrollar esta propuesta.
Improving Transgenesis Efficiency and CRISPR-Associated Tools Through Codon Optimization and Native Intron Addition in Pristionchus Nematodes
Authors: Han Ziduan , Lo Wen-Sui , Lightfoot James W , Witte Hanh , Sun Shuai , Sommer Ralf J 
Published: October 2020

Abstract
A lack of appropriate molecular tools is one obstacle that prevents in-depth mechanistic studies in many organisms. Transgenesis, clustered regularly interspaced short palindromic repeats (CRISPR)-associated engineering, and related tools are fundamental in the modern life sciences, but their applications are still limited to a few model organisms. In the phylum Nematoda, transgenesis can only be performed in a handful of species other than Caenorhabditis elegans, and additionally, other species suffer from significantly lower transgenesis efficiencies. We hypothesized that this may in part be due to incompatibilities of transgenes in the recipient organisms. Therefore, we investigated the genomic features of 10 nematode species from three of the major clades representing all different lifestyles. We found that these species show drastically different codon usage bias and intron composition. With these findings, we used the species Pristionchus pacificus as a proof of concept for codon optimization and native intron addition. Indeed, we were able to significantly improve transgenesis efficiency, a principle that may be usable in other nematode species. In addition, with the improved transgenes, we developed a fluorescent co-injection marker in P. pacificus for the detection of CRISPR-edited individuals, which helps considerably to reduce associated time and costs.
Kansans in the Middle of the Pandemic: Risk Perception, Knowledge, Compliance with Preventive Measures, and Primary Sources of Information about COVID-19
Authors: Geana Mugur 
Published: October 2020

Introduction. As we conduct this study, the world is in the grasp of a deadly pandemic. In less than six months since its first diagnosis in Wuhan, China, the COVID-19 infectious disease due to the novel coronavirus has infected over 5,000,000 people and claimed over 350,000 lives. In the United States, most of the cases are in large urban settings along the coasts, but the disease is slowly progressing through the mainland. Kansas, with its particular location in the midwest United States, has seen a relatively small number of cases, but these are increasing. The Kansas government took radical measures to prevent the spread of the disease. According to the Health Beliefs Model, an individual’s perception of risk will dictate engagement with preventive behaviors. Knowledge about the disease and preventive measures drive the risk assessment. Knowledge is dependant on the sources of information used. This study explored these metrics in a sample of Kansans living in the times of the COVID-19 pandemic.
Methods. A combination of snowball samples and random distribution through social media was used to recruit participants to an online survey. The risk and knowledge instrument was developed and validated by WHO Europe. Data collection lasted 96 hours.
Results. The attitudes and behaviors of Kansans concerning COVID-19 were consistent with its location in an area of the country with a relatively lower incidence of the disease. Participants had good knowledge about the disease and preventive measures and were willing to comply with recommendations from local authorities.
Conclusion. Localized information sources that cater to the community are often primary, while social media is not a valuable source for information pertinent to COVID-19.