bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shifting threats and rhetoric: how Republican governors framed Medicaid expansion
Authors: Singer Phillip M. , Rozier Michael 
Published: March 2020

AbstractThe 2012 Supreme Court decision in National Federation of Independent Business v Sebelius gave states the option to adopt the Medicaid expansion as part of the Affordable Care Act. Many states, especially those under Republican control, have since grappled with their decision to implement the expansion. We conduct a comparative analysis of how Republican governors framed their stance on the Medicaid expansion. We analyze public statements on the Medicaid expansion published in two major in-state newspapers from all Republican governors from June 2012 through June 2018. In total we collected, coded and analyzed 3277 statements from 66 newspapers. Several key themes emerge from our analysis. While every Republican governor used oppositional framing as part of their rhetorical response to the Medicaid expansion, the policy had a destabilizing effect on the previously unified opposition to health reform. We find that Republican framing split after the results of the 2012 election and that overall Republican governors shifted towards more supportive framing prior to the 2016 presidential election. Republican governors transformed how they framed their stance towards Medicaid expansion after Donald Trump was elected in 2016, with both supportive and oppositional moral-based framing of expansion increasing. These findings inform how policymakers use rhetoric to support their stance on controversial policies in a hyper-partisan and polarized political environment.
Urban Systems: Mapping Interdependencies and Outcomes to Support Systems Thinking
Authors: Bedinger M. , Beevers L. , Walker G. H. , Visser‐Quinn A. , McClymont K. 
Published: March 2020

AbstractThis paper argues that urban systems issues are design problems on a grand scale and that various disciplines aiming to address them can have only a partial view of the problem. It is necessary to draw boundaries around the detailed analyses of specific issues, but a way to map the wider system, to contextualize and more deeply understand how they are interrelated, is still lacking. Four complexity obstacles related to reasoning about complex systems are in our way, and to our knowledge no existing approach navigates them effectively. We propose a tool called the Abstraction Hierarchy as a way to do just this, in order to frame complex issues on a large scale, in a way accessible to all disciplines. To demonstrate the power of this systems model, the Abstraction Hierarchy is applied to an urban area. Through its application we demonstrate its capability to navigate all four obstacles and investigate previously unexplored space in urban systems research.
Auroral Omega Bands are a Significant Cause of Large Geomagnetically Induced Currents
Authors: Apatenkov S. V. , Pilipenko V. A. , Gordeev E. I. , Viljanen A. , Juusola L. , Belakhovsky V. B. , Sakharov Ya. A. , Selivanov V. N. 
Published: March 2020

AbstractThe strongest event of geomagnetically induced currents (GIC) detected by the North‐West Russian GIC network occurred during the main phase of the magnetic storm on 28 and 29 June 2013. Extremely high value, 120 A, was recorded in the 330 kV transformers on Kola Peninsula in the 04–07 magnetic local time (MLT) sector. The Defense Meteorological Satellite Program (DMSP) spacecraft took a sequence of ultraviolet (UV) auroral images in the southern hemisphere and observed multiple omega bands. The ionospheric equivalent electric currents based on the International Monitor for Auroral Geomagnetic Effects (IMAGE) magnetometer network reveal a sequence of current vortex pairs moving eastward with the speed of 0.5–2.5 km/s that fits to the electrodynamics scheme of omega bands. Although the temporal variations of the associated current system are slow, the omega bands can be responsible for strong magnetic variations and GIC due to fast propagations of currents in the azimuthal direction.
Under‐Ice Phytoplankton Blooms in the Central Arctic Ocean: Insights From the First Biogeochemical IAOOS Platform Drift in 2017
Authors: Boles Elisabeth , Provost Christine , Garçon Véronique , Bertosio Cécilia , Athanase Marylou , Koenig Zoé , Sennéchael Nathalie 
Published: March 2020

AbstractIn April 2017, the first Ice Atmosphere Arctic Ocean Observing System (IAOOS) platform equipped with biogeochemical sensors was deployed near the North Pole. Over the next 8 months it meandered southward with the ice, collecting measurements in the upper 250 m of Amundsen Basin, the Gakkel Ridge, Nansen Basin, and Fram Strait. Two distinct periods of primary production were encountered. The first bloom developed in the mixed layer in Amundsen Basin in May, reaching maximum chlorophyll a concentrations on the order of ~ 0.5 mg m−3 by the end of June. This bloom occurred earlier in the year than any other recorded bloom in Amundsen Basin, despite very limited under‐ice light due to a thick layer of snow. The second bloom, encountered in Nansen Basin in August, was significantly larger (mean profile maximum chlorophyll a was 1.45 mg m−3). Examinations of the optical community index and colored dissolved organic matter concentrations suggest that the spring bloom consisted of small phytoplankton which may have been mixotrophic, while the summer bloom contained a greater diversity of planktonic size classes. The data set demonstrates the heterogeneity of Arctic under‐ice primary production, and is a valuable resource for validating coupled Earth System models.
Numerical Simulation of Stepping and Branching Processes in Negative Lightning Leaders
Authors: Syssoev A. A. , Iudin D. I. , Bulatov A. A. , Rakov V. A. 
Published: March 2020

AbstractA numerical model with physical timing and grid spacing of 3 m is applied to studying the progression (including stepping and branching) of negative lightning stepped leader. The asymmetry between positive and negative streamers is taken into account via using polarity‐dependent initiation and propagation field thresholds. The stepped nature of negative leader is confirmed to be caused by this asymmetry. The step formation process of the negative leader is modeled to begin with the appearance of space stems inside and in the immediate vicinity of its streamer zone (corona streamer burst completing the preceding step). Some of those space stems evolve into space leaders, which can connect to the primary leader channel, thereby facilitating its extension. Model‐predicted morphology and dynamics of negative leaders are in good agreement with the recent recordings of lightning stepped and dart‐stepped leaders obtained using high‐speed video cameras, and their electrical parameters are in line with the current knowledge on negative lightning leaders.
Efficient Nighttime Biogenic SOA Formation in a Polluted Residual Layer
Authors: Zaveri Rahul A. , Shilling John E. , Fast Jerome D. , Springston Stephen R. 
Published: March 2020

AbstractOrganic nitrates formed from nighttime reaction between anthropogenic nitrate radicals (NO3) and biogenic volatile organic compounds (BVOCs) are an important but highly uncertain source of secondary organic aerosol (SOA). Here we report on the enhanced nighttime biogenic SOA formation observed in a polluted residual layer over Sacramento, California, the morning of 15 June 2010 during the Carbonaceous Aerosols and Radiative Effects Study (CARES). Trajectory analysis showed that the residual layer air, containing isoprene and trace amounts of monoterpenes left over after nighttime oxidation, was influenced by the San Francisco Bay Area emissions the previous evening. The residual layer aerosol was also enriched in nitrate, with about 64% of it estimated to be in the form of organic nitrates. The nitrate:organic mass ratio of the SOA was about 0.47 ± 0.044, which corresponds to the range typically found in isoprene mononitrates. Assuming the SOA was composed of organic mononitrates, its nominal molecular weight was estimated at 186 ± 11 g mol−1, consistent with the highly functionalized isoprene hydroxynitrates that have been observed in the particle phase in the southeast United States. Overall, our findings show that the efficiency of nighttime biogenic SOA formation, expressed as the change in organic aerosol mass relative to carbon monoxide (∆OA/∆CO), equals ~100 μg m−3 ppmv and is comparable to the range previously estimated for enhanced daytime SOA formation from mixed anthropogenic and biogenic emissions during CARES. Assuming the SOA was formed from isoprene oxidation by NO3, we estimated mass yields of up to 0.55, consistent with previous field estimates.
Variability of Isotope Composition of Precipitation in the Southeastern Tibetan Plateau from the Synoptic to Seasonal Time Scale
Authors: Shi Xiaoyi , Risi Camille , Pu Tao , Lacour Jean‐Lionel , Kong Yanlong , Wang Ke , He Yuanqing , Xia Dunsheng 
Published: March 2020

AbstractDaily precipitation samples were collected at four sites in Mount Yulong and Mount Meili regions of southeastern Tibetan Plateau and analyzed for isotopic composition. Combined with water vapor isotopic composition derived from satellites data (Infrared Atmospheric Sounding Interferometer, Tropospheric Emission Spectrometer, and Greenhouse gases Observing Satellite), the factors controlling the variability in the isotopic composition of precipitation are investigated at the synoptic, intraseasonal, and seasonal time scales. At the seasonal scale, the isotope composition in precipitation is controlled by processes along air mass trajectories affecting the water vapor at the large scale (>200 km), especially upstream deep convection and air mass origin, and by local processes transforming the large‐scale water vapor isotopic composition into the precipitation composition, especially rain evaporation and local circulation. At the intraseasonal and synoptic scales, the isotope composition in precipitation is mainly controlled by these local processes. The shorter the time scale of isotopic variations, the smaller the spatial imprint of these variations. The fact that different factors control the isotopic variability at different time scales calls for caution when applying relationships observed at these time scales to interpret isotopic variations at paleoclimatic time scales. While general circulation models successfully capture the isotopic variability and its controlling factors at the seasonal scale, it fails to simulate them at shorter time scales, because it fails to simulate the local processes.
Observation Constrained Aromatic Emissions in Shanghai, China
Authors: Wang Hongli , Yan Rusha , Xu Tingting , Wang Yuhang , Wang Qian , Zhang Tianqi , An Jingyu , Huang Cheng , Gao Yaqin , Gao Yang , Li Xiang , Yu Chao , Jing Shengao , Qiao Liping , Lou Shengrong , Tao Shikang , Li Yingjie 
Published: March 2020

AbstractAromatics in the atmosphere are a large contributor to ozone and secondary organic aerosol formation and have an adverse impact on human health. Observation‐based emissions are urgently needed for air quality management and decision making due to the large uncertainties in the emissions inventories. Atmospheric aromatics were continuously observed at one urban site in Shanghai of China in 2015, which were compared with the simulations of the Community Multiscale Air Quality (CMAQ) model. Large differences were found in the temporal variations between the model and measurements, corroborating with previous studies that the current bottom‐up emission inventories are highly biased. We corrected the aromatic emissions biases of the emission inventories using the observations with the CMAQ simulations, with the assumption that the response relationship of the emissions input and aromatic concentrations was reasonable on a monthly basis in CMAQ simulations, suggesting that the results are dependent on the model performance. The resulting aromatic emissions exhibited clear monthly variations, increasing from 5.5 ± 2.1 Gg month−1 in February to 17.4 ± 7.7 Gg month−1 in July, being different from the flat monthly pattern in the current bottom‐up emissions inventory. Toluene, xylenes, and ethylbenzene dominated aromatic emissions, accounting for ~74% on average but with considerable monthly variations, which was different from the nearly uniform value of 77% throughout the whole year in the emissions inventory. These highly temporally resolved and speciated in situ aromatics measurements provide observation‐based constraints on aromatic emissions, which cannot be obtained from satellite measurements. This study proposes a top‐down emission estimation method constrained by ambient measurements.
Quantifying Provenance and Transport Pathways of Holocene Sediments From the Northwestern Greenland Margin
Authors: Caron Myriam , Montero‐Serrano Jean‐Carlos , St‐Onge Guillaume , Rochon André 
Published: March 2020

AbstractThe mineralogical and geochemical compositions of three sediment cores from the northwestern Greenland continental margin (AMD14‐204 and AMD14‐210) and Kane Basin (AMD14‐Kane2B) were investigated using quantitative X‐ray diffraction and energy‐dispersive X‐ray fluorescence in order to document the impact of ice‐ocean interactions on the sediment provenance and transport pathways during the Holocene. Unmixing of the sediment composition and ratios such as quartz/clays and K/Fe indicate that detrital sediments in cores from the northwest Greenland margin are derived mainly from Prøven granite and reworked Archean gneiss, whereas sediments from Kane Basin are derived mainly from detrital carbonate (Ellesmere Island) and Proterozoic gneiss (Humboldt Glacier). Mineralogical and geochemical signatures also reveal that changes in detrital sediment provenance and transport in the region are strongly interconnected to regional ice stream dynamics, especially during the early Holocene with strong meltwater discharge from the Greenland Ice Sheet associated with the end of deglaciation. With the establishment of milder conditions during the mid‐Holocene and reduced glacial activity once ice sheets retreated inland, sediment inputs via ocean currents became more effective. Thus, detrital proxies in core AMD14‐204, located in the Upernavik cross‐shelf trough, support the hypothesis of an intensification of the West Greenland Current influence after 7.7 cal ka BP, which eventually affected the regional sediment dynamic by a greater contribution from basalt to the sediment supply. Finally, our results suggest that the interactions between climate, glacial dynamics, and surface ocean circulation controlled the paleoenvironmental changes observed in the three cores.
Joint international consensus statement for ending stigma of obesity
Authors: Rubino Francesco , Puhl Rebecca M. , Cummings David E. , Eckel Robert H. , Ryan Donna H. , Mechanick Jeffrey I. , Nadglowski Joe , Ramos Salas Ximena , Schauer Phillip R. , Twenefour Douglas , Apovian Caroline M. , Aronne Louis J. , Batterham Rachel L. , Berthoud Hans-Rudolph , Boza Camilo , Busetto Luca , Dicker Dror , De Groot Mary , Eisenberg Daniel , Flint Stuart W. , Huang Terry T. , Kaplan Lee M. , Kirwan John P. , Korner Judith , Kyle Ted K. , Laferrère Blandine , le Roux Carel W. , McIver LaShawn , Mingrone Geltrude , Nece Patricia , Reid Tirissa J. , Rogers Ann M. , Rosenbaum Michael , Seeley Randy J. , Torres Antonio J. , Dixon John B. 
Published: March 2020

AbstractPeople with obesity commonly face a pervasive, resilient form of social stigma. They are often subject to discrimination in the workplace as well as in educational and healthcare settings. Research indicates that weight stigma can cause physical and psychological harm, and that affected individuals are less likely to receive adequate care. For these reasons, weight stigma damages health, undermines human and social rights, and is unacceptable in modern societies. To inform healthcare professionals, policymakers, and the public about this issue, a multidisciplinary group of international experts, including representatives of scientific organizations, reviewed available evidence on the causes and harms of weight stigma and, using a modified Delphi process, developed a joint consensus statement with recommendations to eliminate weight bias. Academic institutions, professional organizations, media, public-health authorities, and governments should encourage education about weight stigma to facilitate a new public narrative about obesity, coherent with modern scientific knowledge.
Evaluation of Rationally Designed Label-free Stem-loop DNA Probe Opening in the Presence of miR-21 by Circular Dichroism and Fluorescence Techniques
Authors: Farahani Nasrin , Behmanesh Mehrdad , Ranjbar Bijan 
Published: March 2020

AbstractThe characteristic features of stem-loop structured probes make them robust tools to detect targets with high sensitivity and selectivity. The basis of the hairpin based sensors operation is a conformational change that occurs upon hybridization of target with stem-loop probe. The design of the stem-loop probe has an important role in target recognition. Therefore, we designed a label-free stem loop probe for targeting miR-21 as a cancer biomarker investigated by web-based tools; its thermodynamic parameters obtained by thermal UV spectroscopy. The efficiency of stem-loop structure opening in the presence of target and non-target sequences was evaluated by fluorescence spectroscopy and circular dichroism spectro-polarimetry. The results showed that the target sequence opens the structure of hairpin efficiently in comparison to non-target sequences. To optimize the stem-loop hybridization to its target, the buffer ionic strength was changed by adding different concentrations of NaCl, KCl and MgCl2. It was shown that buffering conditions have a significant role in loop structure opening and its optimization, led to an increase in sensitivity detection and have improved LOD from 60 pM to 45 pM.
Self-assembly of Pseudo-Dipolar Nanoparticles at Low Densities and Strong Coupling
Authors: Brito Mariano E. , Carignano Marcelo A. , Marconi Verónica I. 
Published: March 2020

AbstractNanocolloids having directional interactions are highly relevant for designing new self-assembled materials easy to control. In this article we report stochastic dynamics simulations of finite-size pseudo-dipolar colloids immersed in an implicit dielectric solvent using a realistic continuous description of the quasi-hard Coulombic interaction. We investigate structural and dynamical properties near the low-temperature and highly-diluted limits. This system self-assembles in a rich variety of string-like configurations, depicting three clearly distinguishable regimes with decreasing temperature: fluid, composed by isolated colloids; string-fluid, a gas of short string-like clusters; and string-gel, a percolated network. By structural characterization using radial distribution functions and cluster properties, we calculate the state diagram, verifying the presence of string-fluid regime. Regarding the string-gel regime, we show that the antiparallel alignment of the network chains arises as a novel self-assembly mechanism when the characteristic interaction energy exceeds the thermal energy in two orders of magnitude, ud/kBT ≈ 100. This is associated to relevant structural modifications in the network connectivity and porosity. Furthermore, our results give insights about the dynamically-arrested nature of the string-gel regime, where we show that the slow relaxation takes place in minuscule energy steps that reflect local rearrangements of the network.
Iron redox pathway revealed in ferritin via electron transfer analysis
Authors: Chen Peng , De Meulenaere Evelien , Deheyn Dimitri D. , Bandaru Prabhakar R. 
Published: March 2020

AbstractFerritin protein is involved in biological tissues in the storage and management of iron - an essential micro-nutrient in the majority of living systems. While there are extensive studies on iron-loaded ferritin, its functionality in iron delivery is not completely clear. Here, for the first time, differential pulse voltammetry (DPV) has been successfully adapted to address the challenge of resolving a cascade of fast and co-occurring redox steps in enzymatic systems such as ferritin. Using DPV, comparative analysis of ferritins from two evolutionary-distant organisms has allowed us to propose a stepwise resolution for the complex mix of concurrent redox steps that is inherent to ferritins and to fine-tune the structure-function relationship of each redox step. Indeed, the cyclic conversion between Fe3+ and Fe2+ as well as the different oxidative steps of the various ferroxidase centers already known in ferritins were successfully discriminated, bringing new evidence that both the 3-fold and 4-fold channels can be functional in ferritin.
BCAP31, a cancer/testis antigen-like protein, can act as a probe for non-small-cell lung cancer metastasis
Authors: Wang Jing , Jiang Dongbo , Li Zichao , Yang Shuya , Zhou Jiayi , Zhang Guanwen , Zhang Zixin , Sun Yuanjie , Zhang Zhipei , Li Xiaofei , Tao Liang , Shi Jingqi , Lu Yuchen , Zheng Lianhe , Song Chaojun , Yang Kun 
Published: March 2020

AbstractNon-small-cell lung cancer (NSCLC) represents most of lung cancers, is often diagnosed at an advanced metastatic stage. Therefore, exploring the mechanisms underlying metastasis is key to understanding the development of NSCLC. The expression of B cell receptor-associated protein 31 (BCAP31), calreticulin, glucose-regulated protein 78, and glucose-regulated protein 94 were analyzed using immunohistochemical staining of 360 NSCLC patients. It resulted that the high-level expression of the four proteins, but particularly BCAP31, predicted inferior overall survival. What’s more, BCAP31 was closely associated with histological grade and p53 status, which was verified by seven cohorts of NSCLC transcript microarray datasets. Then, three NSCLC cell lines were transfected to observe behavior changes BCAP31 caused, we found the fluctuation of BCAP31 significantly influenced the migration, invasion of NSCLC cells. To identify the pathway utilized by BCAP31, Gene Set Enrichment Analysis was firstly performed, showing Akt/m-TOR/p70S6K pathway was the significant one, which was verified by immunofluorescence, kinase phosphorylation and cellular behavioral observations. Finally, the data of label-free mass spectroscopy implied that BCAP31 plays a role in a fundamental biological process. This study provides the first demonstration of BCAP31 as a novel prognostic factor related to metastasis and suggests a new therapeutic strategy for NSCLC.