bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breast Infrared Thermography Segmentation Based on Adaptive Tuning of a Fully Convolutional Network
Authors: Tayel Mazhar Basyouni , Elbagoury Azza Mahmoud 
Published: May 2020

Background:
Accurate segmentation of Breast Infrared Thermography is an important
step for early detection of breast pathological changes. Automatic segmentation of Breast Infrared
Thermography is a very challenging task, as it is difficult to find an accurate breast contour and extract
regions of interest from it. Although several semi-automatic methods have been proposed for
segmentation, their performance often depends on hand-crafted image features, as well as preprocessing
operations.

Objective:
In this work, an approach to automatic semantic segmentation of the Breast Infrared
Thermography is proposed based on end-to-end fully convolutional neural networks and without
any pre or post-processing.

Methods:
The lack of labeled Breast Infrared Thermography data limits the complete utilization of
fully convolutional neural networks. The proposed model overcomes this challenge by applying
data augmentation and two-tier transfer learning from bigger datasets combined with adaptive
multi-tier fine-tuning before training the fully convolutional neural networks model.

Results:
Experimental results show that the proposed approach achieves better segmentation results:
97.986% accuracy; 98.36% sensitivity and 97.61% specificity compared to hand-crafted
segmentation methods.

Conclusion:
This work provided an end-to-end automatic semantic segmentation of Breast Infrared
Thermography combined with fully convolutional networks, adaptive multi-tier fine-tuning and
transfer learning. Also, this work was able to deal with challenges in applying convolutional neural
networks on such data and achieving the state-of-the-art accuracy.
Coexistence of Ectopic Posterior Pituitary and Sellar/Suprasellar Arachnoid Cyst: A Case Report
Authors: Saylisoy Suzan , Yorulmaz Goknur 
Published: May 2020

Background:
The ectopic posterior pituitary (EPP) is a rare condition characterized by
the ectopic location of the posterior pituitary lobe associated with varying degrees of stalk anomalies.
The arachnoid cysts (AC) are benign lesions of the arachnoid, which account for 1% of all intracranial
space-occupying lesions. Sellar/suprasellar ACs account for approximately 1% of all
ACs. This is the first case of coexistence EPP with sellar/suprasellar AC.

Case Report:
A 67-year-old woman presented with 6 months history of fatigue. Her medical history
was positive for irregular menstruation. Her endocrine examinations indicated low free thyroxine
level with low TSH level, low oestradiol with low gonadotrophin level, slightly elevated prolactin
level. Her Insulin-like growth factor-1 was below the normal levels. Dynamic contrast hypophysis
MRI revealed a sellar cystic lesion with a dimension of 18 × 14 × 14 mm, extending from
the suprasellar cistern, traversing the diaphragma sellae and reaching the level of the floor of the
3rd ventricle, consistent with sellar/suprasellar AC. There was no wall enhancement. The optic chiasm
was compressed. The precontrast T1-weighted magnetic resonance images did not demonstrate
the characteristic bright spot of posterior pituitary within the sella, which was higher in position,
in the region of the median eminence. The pituitary stalk was not present.

Conclusion:
Although speculative, we have a hypothesis to explain how the EPP and sellar/-
suprasellar AC coexist in this patient. Due to the absence of stalk, CSF may enter the sella tursica
from the central aperture of the diaphragma sellae through which normally the stalk passes.
Comprehensive Analysis Reveals GPRIN1 is a Potential Biomarker for Non-sm all Cell Lung Cancer
Authors: Li Jian , Gong Zheng , Jiang Haicheng , Gao Jie , Liang Jianwei , Chang Peng , Hou Yulong 
Published: May 2020

Background:
Non-small cell lung cancer (NSCLC) is one of the most leading cause of
tumor related mortality worldwide. However, the prognosis of NSCLC remained to be poor and
the mechanisms remained to be further investigated.

Objective:
This study aimed to evaluate whether GPRIN1 could be a potential biomarker for
NSCLC.

Methods:
The Cancer Genome Atlas (TCGA, https://cancergenome.nih.gov/) and GEO
database(http://www.ncbi.nlm.nih.gov/geo) were used to analyze the GPRIN1 expression between
normal and human cancers. The protein-protein interaction among centromere proteins was
determined using STRING database (http://www.bork.emblheidelberg.de/STRING/). GraphPad
Prism 5.0 software was utilized for the independent and paired samples’ t-test or ANOVA to
analyze the difference of GPRIN1 expression between two groups.

Results:
This study showed GPRIN1 was overexpressed and correlated to shorter OS time in
human cancers. In NSCLC, we found that GPRIN1 was up-regulated in NSCLC samples compared
to normal lung tissues by analyzing TCGA and GEO datasets. Bioinformatics analysis indicated
that this gene was involved in regulating cancer proliferation and metabolism. Finally, we
identified key targets of GPRIN1 in NSCLC by constructing PPl networks, including MCM3,
KIF20A, UHRF1, BRCA1, KIF4A, HMMR, KIF18B, KIFC1, ASPM, and NCAPG2.

Conclusion:
These analyses showed GPRIN1 could act as a prognosis biomarker in patients with
NSCLC.
Technology-Enabled Self-Management of Chronic Obstructive Pulmonary Disease With or Without Asynchronous Remote Monitoring: Randomized Controlled Trial
Authors: Stamenova Vess , Liang Kyle , Yang Rebecca , Engel Katrina , van Lieshout Florence , Lalingo Elizabeth , Cheung Angelica , Erwood Adam , Radina Maria , Greenwald Allen , Agarwal Payal , Sidhu Aman , Bhatia R Sacha , Shaw James , Shafai Roshan , Bhattacharyya Onil 
Published: June 2020

Background
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality and leads to frequent hospital admissions and emergency department (ED) visits. COPD exacerbations are an important patient outcome, and reducing their frequency would result in significant cost savings. Remote monitoring and self-monitoring could both help patients manage their symptoms and reduce the frequency of exacerbations, but they have different resource implications and have not been directly compared.

Objective
This study aims to compare the effectiveness of implementing a technology-enabled self-monitoring program versus a technology-enabled remote monitoring program in patients with COPD compared with a standard care group.

Methods
We conducted a 3-arm randomized controlled trial evaluating the effectiveness of a remote monitoring and a self-monitoring program relative to standard care. Patients with COPD were recruited from outpatient clinics and a pulmonary rehabilitation program. Patients in both interventions used a Bluetooth-enabled device kit to monitor oxygen saturation, blood pressure, temperature, weight, and symptoms, but only patients in the remote monitoring group were monitored by a respiratory therapist. All patients were assessed at baseline and at 3 and 6 months after program initiation. Outcomes included self-management skills, as measured by the Partners in Health (PIH) Scale; patient symptoms measured with the St George’s Respiratory Questionnaire (SGRQ); and the Bristol COPD Knowledge Questionnaire (BCKQ). Patients were also asked to self-report on health system use, and data on health use were collected from the hospital.

Results
A total of 122 patients participated in the study: 40 in the standard care, 41 in the self-monitoring, and 41 in the remote monitoring groups. Although all 3 groups improved in PIH scores, BCKQ scores, and SGRQ impact scores, there were no significant differences among any of the groups. No effects were observed on the SGRQ activity or symptom scores or on hospitalizations, ED visits, or clinic visits.

Conclusions
Despite regular use of the technology, patients with COPD assigned to remote monitoring or self-monitoring did not have any improvement in patient outcomes such as self-management skills, knowledge, or symptoms, or in health care use compared with each other or with a standard care group. This may be owing to low health care use at baseline, the lack of structured educational components in the intervention groups, and the lack of integration of the action plan with the technology.

Trial Registration
ClinicalTrials.gov NCT03741855; https://clinicaltrials.gov/ct2/show/ NCT03741855
Using Information Technology to Manage the COVID-19 Pandemic: Development of a Technical Framework Based on Practical Experience in China
Authors: Ye Qing , Zhou Jin , Wu Hong 
Published: May 2020

Background
The coronavirus disease (COVID-19) epidemic poses an enormous challenge to the global health system, and governments have taken active preventive and control measures. The health informatics community in China has actively taken action to leverage health information technologies for epidemic monitoring, detection, early warning, prevention and control, and other tasks.

Objective
The aim of this study was to develop a technical framework to respond to the COVID-19 epidemic from a health informatics perspective.

Methods
In this study, we collected health information technology–related information to understand the actions taken by the health informatics community in China during the COVID-19 outbreak and developed a health information technology framework for epidemic response based on health information technology–related measures and methods.

Results
Based on the framework, we review specific health information technology practices for managing the outbreak in China, describe the highlights of their application in detail, and discuss critical issues to consider when using health information technology. Technologies employed include mobile and web-based services such as Internet hospitals and Wechat, big data analyses (including digital contact tracing through QR codes or epidemic prediction), cloud computing, Internet of things, Artificial Intelligence (including the use of drones, robots, and intelligent diagnoses), 5G telemedicine, and clinical information systems to facilitate clinical management for COVID-19.

Conclusions
Practical experience in China shows that health information technologies play a pivotal role in responding to the COVID-19 epidemic.
Analisis Kualitas Layanan Pasien Jaminan Kesehatan Nasional (JKN) Mandiri di Instalasi Rawat Jalan Rumah Sakit Umum Daerah (RSUD) Sekayu Tahun 2019
Authors: Ratnasari Desi , Misnaniarti Misnaniarti , Windusari Yuanita 
Published: May 2020

Latar Belakang: RSUD Sekayu merupakan bagian dari fasilitas layanan kesehatan yang berkewajiban memberikan pelayanan berkualitas sesuai dengan harapan pasien. Penilaian IKM RSUD Sekayu saat ini belum spesifik menggambarkan kualiatas pelayanan dari sisi harapan dan kenyataan layanan pasien JKN Mandiri serta belum dapat memperlihatkan prioritas kategori pelayanan yang akan ditingkatkan/diperbaiki. Tujuan: Menganalisis kualitas, terutama layanan rawat jalan berdasarkan 5 dimensi mutu pelayanan (service quality) terhadap peserta JKN Mandiri. Metode: Metode yang digunakan yaitu cross sectional dengan 151 responden. Teknik pengumpulan data dengan kuesioner berskala likert. Data dianalisis berdasarkan Importance Performance Analiysis dan Gap Analysis. Hasil: Rendahnya tingkat kepuasan pasien pada pelayanan Rawat Jalan (47,7%) dengan tingkat kesesuaian rata-rata 76,89% dan gap rata-rata -1. Pasien cenderung kurang puas terhadap pelayanan berorientasi pada proses (Reliability, Responsiveness, Assurance dan Empathy) dan cenderung puas pada dimensi yang berorientasi pada hasil (Tangible). Diagram kartesius memetakan 10 atribut pada kuadran A, 11 atribut pada kuadran B, 6 atribut pada kuadran C dan 10 atribut pada kuadran D. Kesimpulan: Secara umum kualitas layanan pasien JKN Mandiri di RSUD Sekayu cukup baik pada dimensi Tangible, Responsivenes dan Assurance, sedangkan dimensi Empathy dan Reliability masih dinilai kurang. Perlu ada upaya perbaikan mutu layanan dari semua dimensi mengingat keterkaitan antara dimensi pelayanan.
Lefkowitz, Disobedience and Political Authority
Authors: Davis Shannon 
Published: May 2020

This paper examines political philosopher David Lefkowitiz’s (2007) framework of public disobedience and argues that the acts of civil disobedience employed in the nonviolent Moral Monday protests held at the State Legislative building in the city of Raleigh, North Carolina (United States) during the summer of 2013, are consistent with his account. By definition, public disobedience is a “suitably constrained form of civil disobedience,” compatible with political authority, or a legitimate state's right to rule, because citizens are recognized as holding a moral right to engage in such acts. Specifically, I argue that North Carolina's Moral Mondays activism is a paradigmatic instance of civil, nonviolent resistance by demonstrating how the protests satisfy three necessary conditions of civil disobedience that are also present in Lefkowitz's framework. In my final analysis, I conclude that Moral Mondays are distinguishable from forthright, lawless acts of dissidence that undermine rather than safeguard political authority.
Water Scarcity and Regional Fragmentation in the Middle East
Authors: Tinti Alessandro 
Published: May 2020

The turmoil in the Middle East takes its roots in the sharp incongruence between collective identities and territorial boundaries, but the severe and growing water scarcity significantly affects both the interstate relations and the socio-economic stability of the domestic regimes. Consequently, the access, supply, management and control of water flows are a long-standing source of contention and regional polarization. Nevertheless, the sharing of water resources commands the signing of mutual agreements to determine the parties’ grade of exploitation, thus gradually opening to the institutionalization of a cooperative regime or patterns of joint governance. This article aims to provide a quantitative evaluation of the strategic water-related interactions at the interstate level across the Levant. The assessment provides an overview of the regional transboundary water relations with the purpose of determining whether the Middle East is currently moving toward an increased regionalization or exacerbating the existing rivalries.
Análisis probabilístico de peligro sísmico y terremoto de diseño para Santiago-República Dominicana
Authors: Erazo Kalil 
Published: May 2020

Este artículo presenta los resultados de un Análisis Probabilístico de Peligro Sísmico (APPS) realizado para un sitio ubicado en el centro de la ciudad de Santiago, localizada en la República Dominicana. Para realizar el APPS se utilizaron datos sismológicos recientes de la falla Septentrional (fuente sísmica) con el fin de calibrar un modelo de recurrencia de terremotos, y para calcular las curvas de peligro sísmico de varios parámetros de terremotos, movimiento del suelo y respuesta estructural de interés en aplicaciones de ingeniería sísmica. Los parámetros estudiados incluyen aceleración horizontal pico del suelo y ordenadas del espectro de respuesta de pseudo-aceleración con 5 % de amortiguamiento. El efecto de la incertidumbre de la ubicación de la zona de ruptura en la falla es estudiado usando un análisis de Monte Carlo; con este propósito la ubicación de la ruptura se trata como una variable aleatoria uniforme en la longitud de la falla. Los resultados del APPS son comparados con el espectro de diseño del sitio con 2 % de probabilidad de excedencia en 50 años, especificado en la normativa de diseño de la República Dominicana. Se concluye que hay un 17 % de probabilidad de que el valor actual de las ordenadas espectrales con 2 % de excedencia sea mayor que el valor especificado en el espectro de diseño, debido a incertidumbres relacionadas a la ley de atenuación usada para relacionar la fuente de terremotos y las características del movimiento del suelo en el sitio. Basado en el modelo de atenuación, el espectro de diseño en el sitio es consistente con los espectros generados por terremotos de magnitud (momento) de 7.9, lo cual es cercano al terremoto característico de magnitud de 7.8 estimado en estudios recientes de la falla Septentrional.
Validación de un método heurístico de optimización basado en un sistema de infección por virus
Authors: Díaz Payano Claudia A. 
Published: May 2020

En los problemas de optimización se pueden utilizar diferentes algoritmos para encontrar la solución adecuada. Pero cuando se trata de problemas de complejidad media y alta, como los NP difíciles, las técnicas conocidas como los Algoritmos Genéticos (GA) tiene dificultad en converger o llegar a una solución. En este artículo se presenta la implementación de un Sistema de Virus (VS, por sus siglas en inglés Virus System), que se desarrolla con un nuevo enfoque para resolver problemas de optimización simulando la forma en que un organismo es atacado por un virus. La analogía del VS se aplica a dos tipos de problemas, Onemax, de diferentes longitudes de bits y funciones engañosas (Deceptive Functions) con el objetivo de comprobar su funcionamiento y su potencia de convergencia. Este método es comparado con un GA inspirado en el crecimiento de corales marinos. El VS ha logrado conseguir resultados de alta precisión, con una convergencia del 100 % en ambos problemas y con considerables mejoras comparados con los obtenidos con el GA.
Pertumbuhan Ekonomi Provinsi di Indonesia Berdasarkan Indeks Komposit Pertumbuhan Inklusif dan Faktor yang Memengaruhinya
Authors: Kusumaningrum Saputri , Yuhan Risni Julaeni 
Published: June 2020

Pada tahun 2016, pertumbuhan Produk Domestik Regional Bruto (PDRB) yang tinggi di beberapa provinsi di Indonesia ternyata diikuti pula ketimpangan pendapatan, kemiskinan, dan penganggurannya yang tinggi, seperti di Papua, Gorontalo, dan Sulawesi Tenggara. Kondisi tersebut tentu saja belum sesuai dengan konsep pertumbuhan inklusif, di mana dalam mencapai pertumbuhan ekonomi maka seluruh lapisan masyarakat harus ikut serta dalam prosesnya dan dapat menikmati hasilnya. Berdasarkan hal tersebut, tujuan penelitian ini adalah untuk mengetahui tingkat capaian pertumbuhan inklusif provinsi di Indonesia pada tahun 2016 dan menganalisis faktor-faktor yang memengaruhi capaian tersebut. Pendekatan penelitian menggunakan 2 metode, yaitu indeks komposit pertumbuhan inklusif yang diadopsi dari McKinley (2010) dan regresi berganda untuk menjawab terkait faktor-faktor yang memengaruhinya. Data yang digunakan bersumber dari Badan Pusat Statistik, Kementerian Kesehatan, dan Bank Indonesia.Hasil analisis menujukkan bahwa ternyata belum ada provinsi di Indonesia yang memiliki capaian pertumbuhan inklusif berkategori unggul (nilai indeks: 8-10) selama tahun 2016. Sebagian besar provinsi di Indonesia mencapai pertumbuhan inklusif dengan kategori memuaskan (nilai indeks: 4-7) dan terdapat dua provinsi yang memiliki kategori tidak memuaskan (nilai indeks: < 4), yaitu ProvinsiPapua dan Nusa Tenggara Timur. Selain itu, penelitian ini menganalisis faktor-faktor yang memengaruhi pertumbuhan inklusif provinsi di Indonesia menggunakan analisis regresi linier berganda. Hasil analisis regresi menunjukkan bahwa pembentukan modal tetap bruto, keterbukaan perdagangan, dan rasio kredit Usaha Mikro, Kecil, dan Menengah (UMKM) terhadap PDRB memengaruhi pertumbuhan inklusif.
The Generational Differences in Work Values and its Impact on Workplace Conflicts of Operational Level Employees in Pharmaceutical Companies of Western Province, Sri Lanka
Authors: Preena Rushna , Wanigasekara Saroja 
Published: May 2020

The primary purpose of this study was to identify whether there is a significant impact of generational differences in work values on workplace conflicts. This study is cross-sectional and explanatory research in nature. A standard questionnaire was used to collect primary data through a survey. The respondents were the 120 operational level employees who are working in Pharmaceutical companies in the Western Province of Sri Lanka. Descriptive statistics, correlation analysis, and one-way ANOVA were used to analyze data and make conclusions. Findings revealed that there is no significant impact of generational differences in work values on workplace conflicts. Further analysis done using one-way ANOVA revealed that there is a significant difference in work values between generations and workplace conflicts among generations
THE ABUNDANCE AND DIVERSITY OF THRIPS (THYSANOPTERA: THRIPIDAE) ON CHILI (Capsicum annuum L.) AND CAYENNE (Capsicum frutescens L.) IN BOGOR
Authors: Hutasoit Rudi Tomson , Triwidodo Hermanu , Anwar Rully 
Published: June 2020

The Abundance and Diversity of Thrips (Thysanoptera: Thripidae) on Chili (Capsicum annuum L.) and Cayenne (Capsicum frutescens L.) in Bogor. This research aimed to study the abundance and diversity of thrips on chili pepper and cayenne pepper plants. Observation of thrips was conducted on chili pepper and cayenne pepper in fourteen sites in four different locations in Bogor that are: Dramaga, Cibungbulang, Tenjolaya, and Cisarua. Thrips were collected from leaves and flowers from 10 plant samples that had been selected randomly. The thrips were identified and the number of thrips were calculated. The abundance of adults, nymphs, and total of thrips on the flowers of chili pepper was 0.39, 0.01, and 0.40 thrips/flower respectively. Meanwhile, the abundance of adults, nymphs, and total of thrips on the flowers of cayenne pepper was 0.36, 0.02, and 0.38 thrips/flower respectively. The abundance of adults, nymphs, and total of thrips on the leaves of chili pepper was 0.68, 0.12, and 0.81 thrips/twiq respectively. Meanwhile, the abundance of adults, nymphs, and total of thrips on the leaves of cayenne pepper was 0.47, 0.14, and 0.61 thrips/twiq respectively. Four species of thrips were found infesting flowers of chili pepper and cayenne pepper i. e. Thrips parvispinus, T. hawaiiensis, Scirtothrips dorsalis, and Haplothrips gowdeyi. Species of T. parvispinus, T. hawaiiensis, S. dorsalis belong to suborder of Terebrantia family Thripidae, meanwhile H. gowdeyi belongs to suborder Tubulifera family Phlaeothripidae. T. parvispinus is the most dominant species found infesting flowers and leaves of the chilli pepper and cayenne pepper were 71% and 56 %.
STATUS OF INFESTATION AND BIOLOGY OF PEPPER FRUIT FLY, Atherigona orientalis (Schiner) (Diptera: Muscidae)
Authors: Herawani Febrina , Rauf Aunu , Santoso Sugeng 
Published: June 2020

Status of Infestation and Biology of Pepper Fruit Fly, Atherigona orientalis (Schiner) (Diptera: Muscidae). Numerous muscid flies Atherigona orientalis (Schiner) (Diptera: Muscidae) emerged from fruitfly-infested pepper fruits. It is not known whether A. orientalis is primary or secondary pest, and its biology is poorly studied. Research was conducted with the objectives to determine the status of infestation of A. orientalis on pepper fruits, and to study its biology. Field survey was conducted in pepper fields in Bogor, whereas study on its biology was done in laboratory. Field surveys showed that flies emerged from fruitfly-infested fruits consisted of 86.1% A. orientalis, 4.8% Bactrocera dorsalis, and 9.1% other fly species. Fruits having only A. orientalis representing 79.7% of the infested fruits. Number of A. orientalis flies emerged per fruit ranged 1-24, with an average of 3.5 individuals. Laboratory study showed incubation period of eggs was 1.62 d, larva development lasted 11.93 d, and pupa 5.08 d. Longevity of female adult was 32.85 d and male 31.40 d. Number of eggs laid by a single female ranged 12-191, with an average of 83.80. Net reproductive rate R0 =36.052, intrinsic rate of increase rm = 0.136, mean generation time T = 26.482, doubling time Dt = 5.098, and finite rate of increase λ = 1.145. Overall, our research indicated that A. orientalis was a primary pest of pepper fruits, with a high potential of population increase.