bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular basis for the interaction between human choline kinase alpha and the SH3 domain of the c-Src tyrosine kinase
Authors: Kall Stefanie L. , Whitlatch Kindra , Smithgall Thomas E. , Lavie Arnon 
Published: November 2019

AbstractCholine kinase alpha is a 457-residue protein that catalyzes the reaction between ATP and choline to yield ADP and phosphocholine. This metabolic action has been well studied because of choline kinase’s link to cancer malignancy and poor patient prognosis. As the myriad of x-ray crystal structures available for this enzyme show, chemotherapeutic drug design has centered on stopping the catalytic activity of choline kinase and reducing the downstream metabolites it produces. Furthermore, these crystal structures only reveal the catalytic domain of the protein, residues 80–457. However, recent studies provide evidence for a non-catalytic protein-binding role for choline kinase alpha. Here, we show that choline kinase alpha interacts with the SH3 domain of c-Src. Co-precipitation assays, surface plasmon resonance, and crystallographic analysis of a 1.5 Å structure demonstrate that this interaction is specific and is mediated by the poly-proline region found N-terminal to the catalytic domain of choline kinase. Taken together, these data offer strong evidence that choline kinase alpha has a heretofore underappreciated role in protein-protein interactions, which offers an exciting new way to approach drug development against this cancer-enhancing protein.
Eye-recognizable and repeatable biochemical flexible sensors using low angle-dependent photonic colloidal crystal hydrogel microbeads
Authors: Tsuchiya Mio , Kurashina Yuta , Onoe Hiroaki 
Published: November 2019

AbstractThis paper presents eye-recognizable and repeatable biochemical flexible sensors using low angle-dependent stimuli-responsive photonic colloidal crystal hydrogel (PCCG) microbeads. Thanks to the stimuli-responsive PCCG microbeads exhibiting structural color, users can obtain sensing information without depending on the viewing angle and the mechanical deformation of the flexible sensor. Temperature-responsive PCCG microbeads and ethanol-responsive PCCG microbeads were fabricated from a pre-gel solution of N-isopropylacrylamide (NIPAM) and N-methylolacrylamide (NMAM) by using a centrifuge-based droplet shooting device (CDSD). As a proof-of-concept of thin and flexible biochemical sensors, temperature- and ethanol-sensing devices were demonstrated. By comparing the structural color of the stimuli-responsive PCCG microbeads and the color chart of the device, sensing information, including skin temperature of the human body and ethanol concentration in alcoholic beverages, was obtained successively. We expect that our device design using low angle-dependent stimuli-responsive PCCG microbeads would contribute to the development of user-friendly biochemical sensor devices for monitoring environmental and healthcare targets.
3D hierarchically gold-nanoparticle-decorated porous carbon for high-performance supercapacitors
Authors: Ma Hongfang , Chen Zhanghao , Gao Xiang , Liu Wenfei , Zhu Hanfei 
Published: November 2019

AbstractPorous carbon are excellent electrode materials for energy-storage devices. Here, we present a facile in-situ reduction method to improve the electrochemical performance of carbon materials by gold nanoparticles. The prepared porous carbon microspheres decorated with gold-nanoparticle had a 3D honeycomb-like structure with a high specific surface area of about 1635 m2 g−1, confirmed by scanning electron microscopy, transmission electron microscopy, and the Brunauer-Emmett-Teller method. The electrochemical performance of as-synthesized porous carbon microspheres was exemplified as electrode materials for supercapacitor with a high specific capacitance of 440 F g−1 at a current density of 0.5 A g−1, and excellent cycling stability with a capacitance retention of 100% after 2000 cycles at 10 A g−1 in 6 M KOH electrolyte. Our method opened a new direction for the gold-nanoparticle-decorated synthesis of porous carbon microspheres and could be further applied to synthesize porous carbon microspheres with various nanoparticle decorations for numerous applications as energy storage devices, enhanced absorption materials, and catalytical sites.
High-performance asymmetric optical transmission based on coupled complementary subwavelength gratings
Authors: Li Shuang , Huang Li-rong , Ling Yong-hong , Liu Wen-bing , Ba Chun-fa , Li Han-hui 
Published: November 2019

AbstractAsymmetric transmission (AT) devices are fundamental elements for optical computing and information processing. We here propose an AT device consisting of a pair of coupled complementary subwavelength gratings. Different from previous works, asymmetric dielectric environment is employed for unidirectional excitation of surface plasmon polaritons (SPPs) and thus asymmetric optical transmission, and near-field coupling effect inherent in the coupled complementary structure is exploited to enhance forward transmission and AT behavior, and determine operation bandwidth as well. The influence of asymmetric dielectric environment, effect of vertical and lateral couplings, interactions of electric- and magnetic-dipole moments and the realization of Kerker conditions, are investigated in depth to unearth the AT mechanism and performance. High-performance AT with large forward transmittance of 0.96 and broad bandwidth of 174 nm is achieved at wavelength 1250 nm. Our work helps people to gain a better understanding of near-filed coupling effect in coupled complementary structures, expand their application fields, and it also offers an alternate way to high-performance AT devices.
Direct photon production in pp, p-Pb and Pb-Pb collisions: results from ALICE
Authors: Blau Dmitry 
Published: November 2019

Direct photon measurements provide a tool for testing QCD predictions in pp collisions and valuable information about properties of the quarkgluon matter created in nucleus-nucleus collisions. Comparing direct photon production in pp, p-Pb and Pb-Pb collisions, one can check the scaling with the number of binary collisions expected at high transverse momentum and get insight into the hot and cold hadronic matter properties with soft photons. The elliptic flow of direct photons is another unique possibility to trace the collective flow formation and space-time evolution of the fireball.
We present the latest measurements of direct photon production in pp, p-Pb and Pb-Pb collisions and of the elliptic flow in Pb-Pb collisions at the LHC energies. Comparison to recent theory predictions will be also discussed.
Optimal error estimates of the semidiscrete discontinuous Galerkin methods for two dimensional hyperbolic equations on Cartesian meshes using Pk elements
Authors: Liu Yong , Shu Chi-Wang , Zhang Mengping 
Published: November 2019

In this paper, we study the optimal error estimates of the classical discontinuous Galerkin method for time-dependent 2-D hyperbolic equations using Pk elements on uniform Cartesian meshes, and prove that the error in the L2 norm achieves optimal (k + 1)th order convergence when upwind fluxes are used. For the linear constant coefficient case, the results hold true for arbitrary piecewise polynomials of degree k ≥ 0. For variable coefficient and nonlinear cases, we give the proof for piecewise polynomials of degree k = 0, 1, 2, 3 and k = 2, 3, respectively, under the condition that the wind direction does not change. The theoretical results are verified by numerical examples.
Lidocaine-Epinephrine-Tetracaine Gel Is More Efficient than Eutectic Mixture of Local Anesthetics and Mepivacaine Injection for Pain Control during Skin Repair in Children: A Prospective, Propensity Score Matched Two-Center Study
Authors: Königs Ingo , Wenskus Julia , Boettcher Johannes , Reinshagen Konrad , Boettcher Michael 
Published: November 2019

AbstractIntroduction Skin lacerations are common in children and their repair is a very unpleasant experience for a child. While pain management has been recognized as a key element of high-quality patient care, recent studies report that pain management in the pediatric emergency departments is still suboptimal. Lidocaine-epinephrine-tetracaine (LET) gel could potentially improve the traumatic experience caused by skin repair as it obviates the need for infiltration. Thus, the aim of the current study was to compare local eutectic mixture of local anesthetics (EMLA) plus mepivacaine infiltration with topical anesthetics (LET-gel).Materials and Methods Prospective, propensity score-matched multicenter study including all children between 3 and 16 years presented at two centers. After anesthetics (LET vs. EMLA and infiltration) standardized skin repair was performed. Pain assessment was performed using the faces pain rating scale or visual analogue scale. Follow-up, performed 2 weeks after initial presentation, assessed wound infection rates and overall satisfaction.Results Of 73 subjects 59 children (37 LET vs. 22 EMLA) were included after propensity score matching. Groups had similar baseline characteristics. Pretreatment was significantly less painful in LET versus local anesthetics group. Pain during skin repair was similar between groups (LET and EMLA with mepivacaine infiltration) and both groups demonstrated similar efficacy (procedure time, need for secondary infiltration, infection rate). Ultimately, pain levels during pretreatment and the surgical procedure were perceived significantly higher by the children than estimated by parents or surgeons.Conclusion In conclusion, it appears that LET is superior to conventional anesthesia including mepivacaine infiltration in the pediatric emergency departments. Pretreatment with LET is significantly less painful but equally effective. Hence, we recommend LET as a topical anesthetic in the pediatric emergency department.
Synchronization: a framework for examining emotional climate in classes
Authors: Eilam Efrat 
Published: November 2019

AbstractThis conceptual paper stems from a growing body of research examining the roles and functions of emotional climate (EC)—the collective state of students’ shared emotions—in classrooms. It suggests that EC in classrooms can be analyzed as asynchronizationphenomenon. Synchronization is a natural phenomenon, in which autonomous objects that produce periodic rhythms adjust these rhythms to one another. The purpose of this article is thus twofold: to position the concept of EC within the broader context of synchronization theory; and to propose a new definition for EC that captures synchronization aspects. This paper first explains the theory of synchronization. It then critically discusses several sociological and biological theories regarding emotions, and the implications of these theories for teaching and learning. It subsequently delves into current conceptualizations of EC, and the descriptors used to characterize EC in classrooms. On the backdrop of this theoretical review, an argument is developed that humans’ produced emotions can be viewed as autonomous rhythmic oscillators that have the capacity to synchronize with one another, and that, consequently, EC can be studied as a form of synchronization within an ensemble of oscillators. Finally, a new definition of EC is proposed that integrates essential synchronization features. Overall, this paper suggests that synchronization theory can provide a framework of analysis of EC as a holistic phenomenon, not reduced to discrete emotional events. This approach may contribute to enhancing explanatory and predictive capacities in the study of EC.
Cell adhesion signals regulate the nuclear receptor activity
Authors: Sugimoto Kotaro , Ichikawa-Tomikawa Naoki , Kashiwagi Korehito , Endo Chihiro , Tanaka Satoshi , Sawada Norimasa , Watabe Tetsuya , Higashi Tomohito , Chiba Hideki 
Published: November 2019

Significance
Cell adhesion is indispensable for multicellular organisms to form cohesive sheets and to serve as tissues and organs. In addition to the adhesive activity, it exhibits the signaling ability to organize a variety of cellular processes. However, the mechanism by which the cell adhesion signaling influences the cellular events, especially on regulation of gene expression, remains obscure. We determine that the cell adhesion signaling originated from the tight-junction protein claudin-6, which targets members of the nuclear receptor superfamily, such as retinoic acid receptor γ and estrogen receptor α, thereby regulating expression of the respective target genes. This signaling provides insight into regulation of nuclear receptor activity by cell adhesion.
Branched unwinding mechanism of the Pif1 family of DNA helicases
Authors: Singh Saurabh P. , Soranno Andrea , Sparks Melanie A. , Galletto Roberto 
Published: November 2019

Significance
DNA helicases are motor proteins that operate on nucleic acids during DNA replication, recombination, and repair. Repetitive translocation on and unwinding of nucleic acids is an emerging property of multiple helicases. How this repetitive enzymatic activity may be used for function remains unclear. For the 5′-3′ Pif1 family of helicases our data suggest a model in which a highly processive opening of short stretches of DNA is all that this class of nonreplicative helicases need to achieve when their function is coupled to DNA replication.
La réinvention de l’imaginaire héroïque dans la bande dessinée d’aventure
Authors: Álvares Cristina 
Published: November 2019

AbstractThis paper aims at describing the specific contribution of Franco Belgianbande dessinée(BD) to the modern redefinition of the heroic imaginary by reshaping adventure and its subject, the hero. It focuses on the articulation of two major features of the new paradigm Hergé has created: the unprecedented disjonction between adventure and ordinary life (time, family) and the organization of the hero into two characters (the main character and the sidekick). We examine the variations of the tintinesque paradigm in the historicalSpirouas well as in the contemporarySpirou, in order to grasp how the autonomy of the adventure and of the main character has been shaken by the intrusion of time and domestic life brought about by the elucidation of the indetermined regions of Spirou’s fictionnal world.
Comprehensive assessment on the ecological stress of rapid land urbanization per proportion, intensity, and location
Authors: Li Pingxing , Cao Hui 
Published: November 2019

ABSTRACT
Aiming at assessing the ecological stress of land urbanization comprehensively, three perspectives are considered and combined, i.e. the amount effect with the proportion of construction lands as the indicator, the intensity effect per the density of environmental pollutant emissions, and the location effect based on their spatial distribution in the heterogeneous landscape. The quantitative results of Southern Jiangsu case in Eastern China show the single-perspective ecological stress are spatially different; the proportion effect is higher in city propers which are more densely populated and industrialized. However, the intensity effect is more significant for units along the Yangtze river where heavy industries are gathered, while the location effect is higher in “ecologically suitable” regions. As the integration of proportion, intensity, and location effects, the comprehensive stress differs across Southern Jiangsu and are also different with the single-perspective results. Dominant stressors of each unit are spatially distinct, which benefits policy-makers in targeting their objectives as per primary influencing factors. It is concluded that the comprehensive assessment could efficiently reveal the spatial differentiation of the ecological effects of land urbanization and also the differentiated role of different factors for each unit.
Balance, Yoga, Neoliberalism
Authors: Rosen Alessandra 
Published: November 2019

AbstractBalance is a socially valorized quality in the United States, and yoga a social practice widely claimed to provide it. In this article, I investigate the semiotic logics of this widespread quality and theorize its relationship to the social practice of yoga and to political projects of neoliberalism and second-wave feminism in the United States. Analyzing ethnographic interviews that I conducted with white female yoga instructors in New York City in the summer of 2016, I show that balance is invoked by speakers as a guide to repurpose chronotopically anchored models of yoga to their contemporary lives. Balance provides speakers a sense that the chronotopic contrasts in these models correspond and are compatible with one another. Identifying three linked semiotic relationships upon which balance’s logics rely—contrast, correspondence, and compatibility—I argue that speakers’ interpretation of these logics is mediated by their social positioning as middle-class white women within a neoliberal political economy in the United States.
Classification of crop flours based on protein contents using near infra-red spectroscopy and principle component analysis
Authors: Yuliyanda I , Masithoh R E , Khuriyati N , Saputro A D 
Published: November 2019

Abstract
Indonesia has abundant crops that can be used as carbohydrate sources. Those crops are made into flour to prolong the shelf life, as well to ease for handling and cooking. Crops as carbohydrate sources are usually high energy but low protein. The aim of this research was to classify flours made of various crops using near infra-red spectroscopy (NIRS) and principle component analysis (PCA). The samples used in this study were six types of flour made of banana, breadfruit, taro, arrowroot, purple sweet potato, and modified cassava (mocaf). The reflectance data were taken using the NIRFlex N500 Fiber Optic Solids Cell at wavelengths of 1000-2500 nm. The spectral obtained were pre-processed and analyzed using The Unscrambler X version 10.5.1. Three pre-processing methods were used, i.e. 1st Savitzky Golay Derivative, Normalization, and Standard Normal Variate (SNV). PCA was able to classify flours based on types of crops. The best transformation was SNV which was able to classify all groups of samples with 100% success rate. PCA model was also able to differentiate low and high protein level of samples aligned with the chemical analysis.
Development of android-based interface to determine color additives in food embedded with convolution neural networks technique
Authors: Pribadi W , Masithoh R E , Nugroho A P , Radi  
Published: November 2019

Abstract
Recent advanced technology enables Android smartphone suitable for quality evaluation of food. In this research, image processing technique was used to detect food color additives. In this research, a smartphone application was developed to determine the availability of color additives in food products. Local food namely geplak was made by adding food grade (i.e. tartrazine and erythrosine) and non-food grade (Rhodamin B and Methanyl Yellow) additives in three concentrations. A mobile phone captured geplak images resulting 1200 images which were divided into 1000 images for training and 200 images for validation. Image data was processed with the python programming language of tensorflow function. The output of python in nominal weight was then trained and tested by using a convolutional neural networks (CNN) method. The weights were then processed by Android Studio version 3.2.1 using.java as backend from CNN and.xml as an application layout. Validation result showed that the program successfully determined class of food additive in high degree accuracy of 98 %.
Optimization of waste combinations during decomposition of domestic organic waste using the response surface methodology
Authors: Aliwarga H K , Sutiarso L , Widada Jaka , Nugroho B D A 
Published: November 2019

Abstract
Accumulation of domestic organic waste needs to be processed because it can cause negative effects on the environment. Domestic organic waste can be decomposed into high value products of secondary metabolite by using bacteria like biopesticide. Composition of domestic organic waste as a substrate can affect the decomposition of that waste. This research aims to investigate the optimum composition of domestic waste and additional materials in treating domestic organic waste by using Streptomyces sp GMR-22. Composition of the waste and additional materials was determined by proximate nutrition factors of the ash, protein, fat, and carbohydrate contents and optimized by using response surface methodology (RSM). The temperature and moisture was set to 37°C and 60% respectively. The response was demonstrated by the number of Streptomyces sp GMR-22 on the eight day of the solid-state fermentation (SSF) process. The results show that the highest cell number of Streptomyces sp GMR-22 on eight days was resulted from the combination of 5.25 g ash, 5.5 g protein, 1.5 g fat, and 41 g carbohydrate on resulting 2,8 x 109 cells/gram of substrate. The RSM results indicated that carbohydrate and protein contents were the main factors on the growth of Streptomyces sp. GMR-22. On the other hand, ash had a low significance and fat had no significant effect. In the processing of domestic organic waste through SSF which was based on the proximate value, the RSM results can be used to determine nutrition priorities that must be met.
Positioning of soil moisture sensors for actual conditions of crop water requirement in the controlled drip irrigation system
Authors: Rizqi FA , Murtiningrum  , Ngadisih  
Published: November 2019

Abstract
Controlled drip irrigation systems are one of the most efficient irrigation systems. The soil moisture sensor has a problem with positioning in the soil which causes errors in reading the actual moisture levels and failure to meet the actual crop water requirements. This research aims to determine the optimum position of the soil moisture sensor that represents the actual condition of the root crop water requirements. Knowledge of soil wetted arising from the infiltration of an efficient controlled irrigation system, determines the position of the sensor. The experiment used 26 soil moisture sensor and approached the ratio comparison between the observation of the volume wetting and the volume of the wetting sensor moisture in each segment with an interval of 6 minutes. Indicated the sensor at that location represented actual wetted these occurred in a controlled drip irrigation system. The results showed, the sensors of soil moisture numbers 16, 17 and 18 have the best R2 average value of 0.973, 0.953 and 0.931. These values showed that optimal position of the soil moisture sensor, which represents the actual condition of the crop water requirements. Thus, in the application of drip irrigation the position of the optimal soil moisture sensor is controlled at a depth of 10 cm at a radius of 5 cm from the emitter.
The use of oven as a device to temper molten Dark Chocolate
Authors: Kurniasari J , Cahyani A , Nafingah R , Rahayoe S , Harmayani E , Saputro A D 
Published: November 2019

Abstract
Tempering is one of the most important processes in chocolate making. Tempering is needed to ensure that chocolate has correct melting point, hardness, snap and gloss. After tempering, cocoa butter crystallises in polymorphic form beta V, resulting in chocolate with melting point in the range of 33-34°C. This work investigated the impact of crystal maturation duration and holding time of tempering process on hardness and appearance of dark chocolate. Five durations of crystal maturation, namely 1,3,5,and 7 days and five holding time namely 3,6,9,12,15 and minutes were used as variables. The results showed that hardness of chocolate had propensity to increase as the maturation duration was prolonged. Similar trend was also observed as the holding time increased. With regard to the colour, the L*, a* and b* values tended to decrease as the duration of crystal maturation increased. The use oven method, thus, seemed to have potential for small-scale production of dark chocolate.