bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contact Mechanics of a Thin Layer Pressed Onto a Substrate by a Line Load
Authors: Parel K. S. 
Published: December 2019

Abstract
A fundamental plane frictional receding contact of a thin layer pressed onto a substrate is solved with the insertion of distributions of dislocations. The new formulation overcomes the restriction of standard contact analysis with the distributed dislocation technique, which requires the distributions to be square root bounded to zero or square root singular at the ends of the area of insertion. This new formulation opens up a range of plane frictional receding contacts to theoretical study. Solutions are obtained for the basic plane receding contact problem of a homogeneous linear elastic semi-infinite layer pressed by a line load onto a half-plane of the same material with a Coulomb friction interface. The frictional dependence of receding contact behavior is identified and discussed.
Arrangement Effects of 30 deg Inclined Teardrop-Shaped Dimples on Film Cooling Flow Over Dimpled Cutback Surface at Airfoil Trailing Edge Investigated by 2D3C-PTV
Authors: Yamamoto Shohei , Murata Akira , Saito Hiroshi , Iwamoto Kaoru 
Published: December 2019

Abstract
The objective of this study is to determine the differences in flow fields between the 30 deg in-line and staggered arrangements of teardrop-shaped dimples, and to explain why the surface-averaged Nusselt number with the 30 deg in-line arrangement was 28.7% higher than that with the 30 deg staggered arrangement in our previous study. Measurements of the instantaneous velocity fields over the dimpled cutback surfaces in the two arrangements were performed at five spanwise cross sections using two-dimensional three-component particle tracking velocimetry (2D3C-PTV). Recirculation flows were observed only inside the dimples in the in-line arrangement, and the region above the recirculation flows exhibited a higher Reynolds shear stress. In this region, turbulent mixing between the high-speed cooling-flow and the low-speed recirculation-flow can be promoted. Streamlines of the time-averaged velocities showed that approximately half the fluid flowing out of a teardrop-shaped dimple in the in-line arrangement hardly flowed into the ones downstream. The remainder of the fluid mostly flowed into the dimple immediately downstream, and the inflow of the fluid into further downstream dimples decreased gradually. From the PTV results, we can deduce that the fluid motions in the in-line arrangement leads to a larger temperature-difference between the dimple wall and the fluid because the inflow of fluid heated inside upstream dimples into the downstream ones is less than in the staggered arrangement. Consequently, the Nusselt number in the in-line arrangement was higher.
Obstetric perineal tears, sexual function and dyspareunia among primiparous women 12 months postpartum: a prospective cohort study
Authors: Gommesen Ditte , Nøhr Ellen , Qvist Niels , Rasch Vibeke 
Published: December 2019

ObjectiveSexuality is an important aspect of human identity and contributes significantly to the quality of life in women as well as in men. Impairment in sexual health after vaginal delivery is a major concern for many women. We aimed to examine the association between degree of perineal tear and sexual function 12 months postpartum.DesignA prospective cohort studySettingFour Danish hospitals between July 2015 and January 2019ParticipantsA total of 554 primiparous women: 191 with no/labia/first-degree tears, 189 with second-degree tears and 174 with third-degree/fourth-degree tears. Baseline data were obtained 2 weeks postpartum by a questionnaire and a clinical examination. Sexual function was evaluated 12 months postpartum by an electronic questionnaire (Pelvic Organ Prolapse/Urinary Incontinence Sexual Function Questionnaire (PISQ-12)) and a clinical examination.Primary outcome measuresTotal PISQ-12 score and dyspareuniaResultsEpisiotomy was performed in 54 cases and 95 women had an operative vaginal delivery. The proportion of women with dyspareunia was 25%, 38% and 53% of women with no/labia/first-degree, second-degree or third-degree/fourth-degree tears, respectively.Compared with women with no/labia/first-degree tears, women with second-degree or third-degree/fourth-degree tears had a higher risk of dyspareunia (adjusted relative risk (aRR) 2.05; 95% CI 1.51 to 2.78 and aRR 2.09; 95% CI 1.55 to 2.81, respectively). Women with third-degree/fourth-degree tears had a higher mean PISQ-12 score (12.2) than women with no/labia/first-degree tears (10.4).ConclusionsImpairment of sexual health is common among primiparous women after vaginal delivery. At 12 months postpartum, more than half of the women with a third-degree/fourth-degree tear experienced dyspareunia. Women delivering with no/labia/first-degree tears reported the best outcomes overall. Thus, it is important to minimise the extent of perineal trauma and to counsel about sexuality during and after pregnancy.
Exercise for falls prevention in community-dwelling older adults: trial and participant characteristics, interventions and bias in clinical trials from a systematic review
Authors: Ng Christopher A C M , Fairhall Nicola , Wallbank Geraldine , Tiedemann Anne , Michaleff Zoe A , Sherrington Catherine 
Published: December 2019

IntroductionThere is strong evidence that exercise prevents falls in community-dwelling older people. This review summarises trial and participant characteristics, intervention contents and study quality of 108 randomised trials evaluating exercise interventions for falls prevention in community-dwelling older adults.MethodsMEDLINE, EMBASE, CENTRAL and three other databases sourced randomised controlled trials of exercise as a single intervention to prevent falls in community-dwelling adults aged 60+ years to May 2018.Results108 trials with 146 intervention arms and 23 407 participants were included. Trials were undertaken in 25 countries, 90% of trials had predominantly female participants and 56% had elevated falls risk as an inclusion criterion. In 72% of trial interventions attendance rates exceeded 50% and/or 75% of participants attended 50% or more sessions. Characteristics of the trials within the three types of intervention programme that reduced falls were: (1) balance and functional training interventions lasting on average 25 weeks (IQR 16–52), 39% group based, 63% individually tailored; (2) Tai Chi interventions lasting on average 20 weeks (IQR 15–43), 71% group based, 7% tailored; (3) programmes with multiple types of exercise lasting on average 26 weeks (IQR 12–52), 54% group based, 75% tailored. Only 35% of trials had low risk of bias for allocation concealment, and 53% for attrition bias.ConclusionsThe characteristics of effective exercise interventions can guide clinicians and programme providers in developing optimal interventions based on current best evidence. Future trials should minimise likely sources of bias and comply with reporting guidelines.
РОЛЬ СУЧАСНИХ ІНФОРМАЦІЙНИХ ТЕХНОЛОГІЙ У ЗАБЕЗПЕЧЕННІ ЯКОСТІ МЕДИЧНОЇ ОСВІТИ
Authors: Lisovyi V. M. , Kapustnyk V. A. , Markovskyi V. D. , Zavgorodnii I. V. , Matsko A. M. 
Published: December 2019

Мета роботи – з’ясувати вплив інформаційних технологій у трансформації післядипломної медичної освіти.
Основна частина. У статті наведено роль сучасних інформаційних технологій у забезпеченні якості медичної освіти. Реформа системи охорони здоров’я потребує послідовних змін у підготовці сучасного фахівця з належним рівнем компетентностей, володіння теоретичними знаннями та практичними навичками, підготовленого до ринкових відносин у питаннях надання медичних послуг. Однією з важливих передумов забезпечення якості вищої медичної освіти є впровадження в навчальний процес електронної освіти (e-learning) нового рівня або «відкритого навчання», що є особливо важливим для підготовки сучасного фахівця.
Висновок. З метою поліпшення якості медичної освіти необхідне урахування певних особливостей медичної електронної освіти, зокрема її практично-орієнтованого змісту, стандартизації прийняття рішень лікувально-діагностичного спрямування (протоколи надання медичної допомоги), посилення вимог до набуття навичок менеджера медичної галузі, готовності до роботи на ринку праці та медичних послуг.
ПЕРШИЙ ДОСВІД ПІДГОТОВКИ ІНОЗЕМНИХ СТУДЕНТІВ ФРАНКОМОВНОЇ ФОРМИ НАВЧАННЯ У ДЕРЖАВНОМУ ЗАКЛАДІ «ДНІПРОПЕТРОВСЬКА МЕДИЧНА АКАДЕМІЯ МІНІСТЕРСТВА ОХОРОНИ ЗДОРОВ’Я УКРАЇНИ»
Authors: Pertseva T. O. , Naumenko L. Yu. , Zakharov S. V. , Nefodov O. O. , Shatorna V. F. , Nefodova O. O. , Kuznetsova O. V. , Shamelashvіlі K. L. 
Published: December 2019

Мета роботи – проаналізувати рівень та якість підготовки іноземних студентів франкомовної форми навчання у Державному закладі «Дніпропетровська медична академія Міністерства охорони здоров’я України».
Основна частина. Висвітлено різні аспекти підготовки іноземних громадян у вищій медичній школі на додипломному етапі. Наведено основні заходи щодо створення умов для вдосконалення системи підготовки іноземних громадян. Акцентовано увагу на франкомовному напрямі освітнього процесу кафедр першого курсу спеціальностей «Медицина» та «Стоматологія».
Висновок. Комплексна підготовка, а саме вивчення нової мови викладання, підготовка якісного навчально-методичного забезпечення та ефективна вмотивованість дозволили розпочати викладання у Дніпропетровській медичній академії французькою мовою.
Tara Pacific Expedition’s Atmospheric Measurements of Marine Aerosols across the Atlantic and Pacific Oceans: Overview and Preliminary Results
Authors: Flores J. M. , Bourdin G. , Altaratz O. , Trainic M. , Lang-Yona N. , Dzimban E. , Steinau S. , Tettich F. , Planes S. , Allemand D. , Agostini S. , Banaigs B. , Boissin E. , Boss E. , Douville E. , Forcioli D. , Furla P. , Galand P. E. , Sullivan M. B. , Gilson É. , Lombard F. , Moulin C. , Pesant S. , Poulain J. , Reynaud S. , Romac S. , Sunagawa S. , Thomas O. P. , Troublé R. , de Vargas C. , Thurber R. Vega , Voolstra C. R. , Wincker P. , Zoccola D. , Bowler C. , Gorsky G. , Rudich Y. , Vardi A. , Koren I. 
Published: December 2019

AbstractMarine aerosols play a significant role in the global radiative budget, in clouds’ processes, and in the chemistry of the marine atmosphere. There is a critical need to better understand their production mechanisms, composition, chemical properties, and the contribution of ocean-derived biogenic matter to their mass and number concentration. Here we present an overview of a new dataset of in situ measurements of marine aerosols conducted over the 2.5-yr Tara Pacific Expedition over 110,000 km across the Atlantic and Pacific Oceans. Preliminary results are presented here to describe the new dataset that will be built using this novel set of measurements. It will characterize marine aerosols properties in detail and will open a new window to study the marine aerosol link to the water properties and environmental conditions.
Delirium is prevalent in older hospital inpatients and associated with adverse outcomes: results of a prospective multi-centre study on World Delirium Awareness Day
Authors:   Geriatric Medicine Research Collaborative
Published: December 2019

Abstract
Background
Delirium is a common severe neuropsychiatric condition secondary to physical illness, which predominantly affects older adults in hospital. Prior to this study, the UK point prevalence of delirium was unknown. We set out to ascertain the point prevalence of delirium across UK hospitals and how this relates to adverse outcomes.

Methods
We conducted a prospective observational study across 45 UK acute care hospitals. Older adults aged 65 years and older were screened and assessed for evidence of delirium on World Delirium Awareness Day (14th March 2018). We included patients admitted within the previous 48 h, excluding critical care admissions.

Results
The point prevalence of Diagnostic and Statistical Manual on Mental Disorders, Fifth Edition (DSM-5) delirium diagnosis was 14.7% (222/1507). Delirium presence was associated with higher Clinical Frailty Scale (CFS): CFS 4–6 (frail) (OR 4.80, CI 2.63–8.74), 7–9 (very frail) (OR 9.33, CI 4.79–18.17), compared to 1–3 (fit). However, higher CFS was associated with reduced delirium recognition (7–9 compared to 1–3; OR 0.16, CI 0.04–0.77). In multivariable analyses, delirium was associated with increased length of stay (+ 3.45 days, CI 1.75–5.07) and increased mortality (OR 2.43, CI 1.44–4.09) at 1 month. Screening for delirium was associated with an increased chance of recognition (OR 5.47, CI 2.67–11.21).

Conclusions
Delirium is prevalent in older adults in UK hospitals but remains under-recognised. Frailty is strongly associated with the development of delirium, but delirium is less likely to be recognised in frail patients. The presence of delirium is associated with increased mortality and length of stay at one month. A national programme to increase screening has the potential to improve recognition.
Risk selection into supplemental private health insurance in China
Authors: Jiang Yawen , Ni Weiyi 
Published: December 2019

Abstract
Background
Information on risk selection is important for the regulation and development of supplemental private health insurance (PHI). The research on risk selection into supplemental PHI has been documented in several developed countries where the regulation of the PHI markets was relatively mature. However, evidence on this important aspect of the supplemental PHI market in China is still absent in the literature. The private insurers in China were not prohibited from discrimination against pre-existing conditions and did not guarantee ongoing enrolment. Therefore, the direction and degree of risk selection could not be inferred using the evidence from the other countries. To provide evidence on risk selection into supplemental PHI in China, we conducted a cross-sectional analysis using data from the 2015 wave of China Health and Retirement Longitudinal Study (CHARLS).

Results
Using probit models, we found that individuals having better self-reported general health were more likely to enrol in PHI in China, suggesting advantageous selection. This result was confirmed by an alternative analysis using an instrumental variable. We also adjusted the realized occurrence of hospitalization by excluding potential moral hazard effect and showed that the adjusted hospitalization risk was negatively associated with PHI enrolment, which also indicated advantageous selection.

Conclusions
The findings suggested potential over-insurance of healthier individuals or under-insurance of less healthy individuals. The regulation of the PHI market in China should aim to address the inefficiency. The current study could also contribute to the information base for policymakers in countries where the PHI markets similarly lack strong regulation.
Recombinant polypeptide of Mycobacterium leprae as a potential tool for serological detection of leprosy
Authors: Barbosa Marcelo dos Santos , de Sousa Iara Beatriz Andrade , Simionatto Simone , Borsuk Sibele , Marchioro Silvana Beutinger 
Published: December 2019

AbstractCurrent prevention methods for the transmission of Mycobacterium leprae, the causative agent of leprosy, are inadequate as suggested by the rate of new leprosy cases reported. Simple large-scale detection methods for M. leprae infection are crucial for early detection of leprosy and disease control. The present study investigates the production and seroreactivity of a recombinant polypeptide composed of various M. leprae protein epitopes. The structural and physicochemical parameters of this construction were assessed using in silico tools. Parameters like subcellular localization, presence of signal peptide, primary, secondary, and tertiary structures, and 3D model were ascertained using several bioinformatics tools. The resultant purified recombinant polypeptide, designated rMLP15, is composed of 15 peptides from six selected M. leprae proteins (ML1358, ML2055, ML0885, ML1811, ML1812, and ML1214) that induce T cell reactivity in leprosy patients from different hyperendemic regions. Using rMLP15 as the antigen, sera from 24 positive patients and 14 healthy controls were evaluated for reactivity via ELISA. ELISA-rMLP15 was able to diagnose 79.17% of leprosy patients with a specificity of 92.86%. rMLP15 was also able to detect the multibacillary and paucibacillary patients in the same proportions, a desirable addition in the leprosy diagnosis. These results summarily indicate the utility of the recombinant protein rMLP15 in the diagnosis of leprosy and the future development of a viable screening test.
An analog hardware solution for compressive sensing reconstruction using gradient-based method
Authors: Orović Irena , Lekić Nedjeljko , Beko Marko , Stanković Srdjan 
Published: December 2019

AbstractThis work proposes an analog implementation of gradient-based algorithm for compressive sensing signal reconstruction. Compressive sensing has appeared as a promising technique for efficient acquisition and reconstruction of sparse signals in many real-world applications. It starts from the assumption that sparse signals can be exactly reconstructed using far less samples than in standard signal processing. In this paper, we consider the gradient-based algorithm as the optimal choice that provides lower complexity and competitive accuracy compared with existing methods. Since the efficient hardware implementations of reconstruction algorithms are still an emerging topic, this work is focused on the design of hardware that will provide fast parallel algorithm execution for real-time applications, overcoming the limitations imposed by the large number of nested iterations during the signal reconstruction. The proposed implementation is simple and fast, executing 400 iterations in 1 ms which is sufficient to obtain highly accurate reconstruction results.
The impact of inclusion, dose and duration of pyrazinamide (PZA) on efficacy and safety outcomes in tuberculosis: systematic review and meta-analysis protocol
Authors: Millard James D. , Mackay Elizabeth A. , Bonnett Laura J. , Davies Geraint R. 
Published: December 2019

Abstract
Background
Pyrazinamide (PZA) is a key component of current and future regimens for tuberculosis (TB). Inclusion of PZA at higher doses and for longer durations may improve efficacy outcomes but must be balanced against the potential for worse safety outcomes.

Methods
We will search for randomised and quasi-randomised clinical trials in adult participants with and without the inclusion of PZA in TB treatment regimens in the Cochrane infectious diseases group’s trials register, Cochrane central register of controlled trials (CENTRAL), MEDLINE, EMBASE, LILACS, the metaRegister of Controlled Trials (mRCT) and the World Health Organization (WHO) international clinical trials registry platform. One author will screen abstracts and remove ineligible studies (10% of which will be double-screened by a second author). Two authors will review full texts for inclusion. Safety and efficacy data will be extracted to pre-piloted forms by one author (10% of which will be double-extracted by a second author). The Cochrane risk of bias tool will be used to assess study quality. The study has three objectives: the association of (1) inclusion, (2) dose and (3) duration of PZA with efficacy and safety outcomes. Risk ratios as relative measures of effect for direct comparisons within trials (all objectives) and proportions as absolute measures of effect for indirect comparisons across trials (for objectives 2 and 3) will be calculated. If there is insufficient data for direct comparisons within trials for objective 1, indirect comparisons between trials will be performed. Measures of effect will be pooled, with corresponding 95% confidence intervals and p values. Meta-analysis will be performed using the generalised inverse variance method for fixed effects models (FEM) or the DerSimonian-Laird method for random effects models (REM). For indirect comparisons, meta-regression for absolute measures against dose and duration data will be performed. Heterogeneity will be quantified through the I2-statistic for direct comparisons and the τ2 statistic for indirect comparisons using meta-regression.

Discussion
The current use of PZA for TB is based on over 60 years of clinical trial data, but this has never been synthesised to guide rationale use in future regimens and clinical trials.
Systematic review registration: International Prospective Register of Systematic Reviews (PROSPERO) CRD42019138735
Evaluation of synthetic formaldehyde and methanol assimilation pathways in Yarrowia lipolytica
Authors: Vartiainen Eija , Blomberg Peter , Ilmén Marja , Andberg Martina , Toivari Mervi , Penttilä Merja 
Published: December 2019

Abstract
Background
Crude glycerol coming from biodiesel production is an attractive carbon source for biological production of chemicals. The major impurity in preparations of crude glycerol is methanol, which is toxic for most microbes. Development of microbes, which would not only tolerate the methanol, but also use it as co-substrate, would increase the feasibility of bioprocesses using crude glycerol as substrate.

Results
To prevent methanol conversion to CO2 via formaldehyde and formate, the formaldehyde dehydrogenase (FLD) gene was identified in and deleted from Yarrowia lipolytica. The deletion strain was able to convert methanol to formaldehyde without expression of heterologous methanol dehydrogenases. Further, it was shown that expression of heterologous formaldehyde assimilating enzymes could complement the deletion of FLD. The expression of either 3-hexulose-6-phosphate synthase (HPS) enzyme of ribulose monosphosphate pathway or dihydroxyacetone synthase (DHAS) enzyme of xylulose monosphosphate pathway restored the formaldehyde tolerance of the formaldehyde sensitive Δfld1 strain.

Conclusions
In silico, the expression of heterologous formaldehyde assimilation pathways enable Y. lipolytica to use methanol as substrate for growth and metabolite production. In vivo, methanol was shown to be converted to formaldehyde and the enzymes of formaldehyde assimilation were actively expressed in this yeast. However, further development is required to enable Y. lipolytica to efficiently use methanol as co-substrate with glycerol.