bluuebunny/crossref_metadata_2025_split huggingface dataset:
cGAS-STING pathway in cancer biotherapy
Authors: Wang Yang , Luo Jingwen , Alu Aqu , Han Xuejiao , Wei Yuquan , Wei Xiawei 
Published: September 2020

AbstractThe activation of the cGAS-STING pathway has tremendous potential to improve anti-tumor immunity by generating type I interferons. In recent decades, we have witnessed that producing dsDNA upon various stimuli is an initiative factor, triggering the cGAS-SING pathway for a defensive host. The understanding of both intracellular cascade reaction and the changes of molecular components gains insight into type I IFNs and adaptive immunity. Based on the immunological study, the STING-cGAS pathway is coupled to cancer biotherapy. The most challenging problem is the limited therapeutic effect. Therefore, people view 5, 6-dimethylxanthenone-4-acetic acid, cyclic dinucleotides and various derivative as cGAS-STING pathway agonists. Even so, these agonists have flaws in decreasing biotherapeutic efficacy. Subsequently, we exploited agonist delivery systems (nanocarriers, microparticles and hydrogels). The article will discuss the activation of the cGAS-STING pathway and underlying mechanisms, with an introduction of cGAS-STING agonists, related clinical trials and agonist delivery systems.
Prosthetic temporomandibular joint reconstruction in a cohort of adolescent females with juvenile idiopathic arthritis
Authors: Lypka Michael , Shah Karina , Jones Jordan 
Published: September 2020

Abstract
Background
Temporomandibular joint (TMJ) arthritis and involvement is commonly seen in Juvenile Idiopathic Arthritis (JIA). Therapy includes conservative measures, but also includes intraarticular corticosteroid injections (IASI) and systemic immunosuppressive therapy. Despite aggressive medical therapy, some patients develop arthritic changes and frank TMJ ankylosis that can result in persistent pain and limitation in range of motion (ROM). A surgical option is prosthetic TMJ replacement with concurrent correction of dentofacial deformities, which can be performed simultaneously. The objective of this study was to evaluate the outcomes of prosthetic TMJ replacement in a cohort of adolescent females with JIA and severe TMJ involvement.

Methods
This is a retrospective case series that took place at one tertiary care center. Patients with a diagnosis of JIA who also underwent alloplastic TMJ replacement were identified through electronic medical record system (EMR) and reviewed. Chart review included analysis of all documents in the EMR, including demographic data, JIA history, surgical complications, ROM of TMJ measured by maximal incisal opening in millimeters (mm) and TMJ pain scores (4-point Likert scale: none, mild, moderate, severe) obtained pre- and postoperatively.

Results
Five female patients, ages 15–17 year when TMJ replacement was performed, had nine total joints replaced with a post-operative follow-up period of 12–30 months. All patients had polyarticular, seronegative JIA and were treated with IASI and multiple immunosuppressive therapies without resolution of TMJ symptoms. One patient had bilateral TMJ ankylosis. Three of the five patients demonstrated significant dentofacial deformities, and all underwent simultaneous or staged orthognathic surgery. All patients had improvement in TMJ pain with most (80%) reporting no pain, and all had similar or improved ROM of their TMJ postoperatively. There was one delayed postoperative infection with Cutibacterium Acnes that presented 15 months after surgery and required removal and reimplantation of prosthesis.

Conclusion
The sequelae of TMJ arthritis and involvement from JIA in the adolescent population can be difficult to treat. Current medical therapy can be successful, however, in select cases that develop chronic changes in the TMJ despite extensive medical therapy, early results show that prosthetic joint replacement maybe a reasonable surgical option. With prosthetic joint replacement pain levels were reduced and range of motion was maintained or improved for all patients.
Affective agnosia: a core affective processing deficit in the alexithymia spectrum
Authors: Lane Richard D. , Solms Mark , Weihs Karen L. , Hishaw Alex , Smith Ryan 
Published: September 2020

AbstractAffective agnosia, an impairment in knowing how one feels emotionally, has been described as an extreme deficit in the experience and expression of emotion that may confer heightened risk for adverse medical outcomes. Alexithymia, by contrast, has been proposed as an over-arching construct that includes a spectrum of deficits of varying severity, including affective agnosia at the more severe end. This perspective has been challenged by Taylor and colleagues, who argue that the concept of affective agnosia is unnecessary. We compare these two perspectives by highlighting areas of agreement, reasons for asserting the importance of the affective agnosia concept, errors in Taylor and colleagues’ critique, and measurement issues. The need for performance-based measures of the ability to mentally represent emotional states in addition to metacognitive measures is emphasized. We then draw on a previously proposed three-process model of emotional awareness that distinguishes affective response generation, conceptualization and cognitive control processes which interact to produce a variety of emotional awareness and alexithymia phenotypes - including affective agnosia. The tools for measuring these three processes, their neural substrates, the mechanisms of brain-body interactions that confer heightened risk for adverse medical outcomes, and the differential treatment implications for different kinds of deficits are described. By conceptualizing alexithymia as a spectrum of deficits, the opportunity to match specific deficit mechanisms with personalized treatment for patients will be enhanced.
Estimation of daily intake of lycopene, antioxidant contents and activities from tomatoes, watermelons, and their processed products in Korea
Authors: Park Hyunjeong , Kim Young-Jun , Shin Youngjae 
Published: September 2020

AbstractTomatoes, watermelons, and processed tomato products contain abundant antioxidant compounds, including lycopene. In spite of the interest in the role of lycopene, little is known about the contribution of tomatoes and tomato products commonly consumed in Korea to the intake of lycopene. In this study, the daily per capita intake values of lycopene and antioxidant compounds and activities of tomatoes, watermelons, and their processed products in Korea were estimated. The daily per capita intake values of lycopene from raw tomatoes, watermelons, tomato ketchup, and tomato juice were measured to be 1.07, 0.54, 0.26, and 0.08 mg/capita/day, respectively. The average lycopene intake of male and female were 1.98 and 1.92 mg/capita/day, respectively. The daily per capita intake value of total phenolics was highest in raw tomatoes (7.21 mg/capita/day), followed by watermelons (1.72 mg/capita/day), tomato ketchup (1.41 mg/capita/day), and tomato juice (0.80 mg/capita/day). The daily per capita intake value of total antioxidant activities also showed a similar pattern to total phenolic results. The overall daily per capita intake of antioxidant content and activities was affected by both the daily per capita intake of each product and the levels of antioxidant content and activities of each product. The daily per capita intake of these products in Korea is currently considerably low, compared to the U.S. and Europe. Thus, an adequate consumption of lycopene-rich products is recommended.
Decision making on financial investment in Turkey by using ARDL long-term coefficients and AHP
Authors: Atmaca Serkan , Karadaş Hacı Ahmet 
Published: September 2020

AbstractMathematical modeling methods are frequently used for solving everyday problems. Decision making, one such method, can be used in every aspect of life for different scales such as micro (households), medium (companies), and macro (states) decisions. Due to the large number of parameters affecting decision, it is possible to make mistakes in the selection of the appropriate investment instrument with classical methods; hence, scarce resources may be wasted, and sometimes it may even be impossible to make a decision. This study seeks to answer the question “Which financial investment instrument should be selected under the current conditions?” using decision making problems. Factors affecting gold, USD, and EURO, which are selected as the financial investment instruments in Turkey, are examined using the autoregressive distributed lag (ARDL) bound test. The selected variables are monthly and belong to the January 2009 to May 2018 period. The ARDL results show that the selected financial investment instruments are affected by most of the factors separately. By using the coefficients obtained from the ARDL model, the analytic hierarchy process (AHP) model was established. According to the results of the model, the EURO was determined as the most suitable financial investment for Ahmet and others with the same preferences.
A case report of a perigraft inflammatory reaction to a Viabahn stent-graft: diagnosis with MRI and treatment with steroids
Authors: Yamamoto Tetsuya , Uzu Kenzo , Sawada Takahiro , Takaya Tomofumi , Kawai Hiroya 
Published: September 2020

Abstract
Background
Perigraft inflammatory reactions to prosthetic graft materials in vascular surgery have been reported; however, to our knowledge, this is the first report of a perigraft inflammatory reaction to a Viabahn stent-graft used in a superficial femoral artery occlusion lesion.

Case presentation
A 76-year-old man with right leg claudication was diagnosed with a right superficial femoral artery occlusion via contrast-enhanced computed tomography. Endovascular treatment included intravascular ultrasound for passing through the true lumen. A 25-cm Viabahn stent-graft (diameter 5 mm) was implanted. The patient developed pain and local swelling of the right thigh 5 days after endovascular treatment. Blood analysis revealed elevated inflammatory marker levels. Magnetic resonance imaging revealed extensive soft-tissue edema and a high perivascular T2 signal around the right superficial femoral artery. Clinical symptoms resolved within 7 days after initiating steroid therapy, which was gradually decreased and halted after 3 weeks. Follow-up magnetic resonance imaging demonstrated substantially reduced inflammation over the following months.

Conclusions
Perigraft inflammatory reaction to a Viabahn stent-graft implant can be immediately diagnosed via magnetic resonance imaging and treated with steroids to reduce the possibility of stent-graft occlusion.
Pelvic vein embolization: an assessment of the readability and quality of online information for patients
Authors: Lee R. J. , O’Neill D. C. , Brassil M. , Alderson J. , Lee M. J. 
Published: September 2020

AbstractIntroductionPelvic congestion syndrome is a controversial topic. Pelvic vein embolization is a minimally invasive treatment for pelvic congestion syndrome. We aimed to assess the quality of information available on the Internet and determine how accessible information provided by the main IR societies was to patients.Materials and methodsThe most commonly used term relating to pelvic vein embolization was searched across the five most-used English language search engines, with the first 25 web pages returned by each engine included for analysis. Duplicate web pages, nontext content and web pages behind paywalls were excluded. Web pages were analyzed for quality and readability using validated tools: DISCERN score, JAMA Benchmark Criteria, HONcode Certification, Flesch Reading Ease Score, Flesch–Kincaid Grade Level, and Gunning–Fog Index.ResultsThe most common applicable term was “Pelvic Vein Embolization”. Mean DISCERN quality of information provided by websites is “fair”. Flesh–Kincaid readability tests and Gunning–Fog Index demonstrated an average “college level” of reading ease. HON code certification was demonstrated in less than one third of web pages. Professional societies and scientific journals demonstrated the highest average JAMA and DISCERN scores, while for-profit organizations and healthcare providers demonstrated the lowest. Only information from 1 of 3 interventional societies was included in the first 25 search engine pages.ConclusionThe quality of information available online to patients is “fair” and outside of scientific journals the majority of web pages do not meet the JAMA benchmark criteria. These findings call for the production of high-quality and comprehensible content regarding interventional radiology, where physicians can reliably direct their patients for information.
Pediatric Solid Tumor Care and Multidisciplinary Tumor Boards in Low- and Middle-Income Countries in Southeast Asia
Authors: Othman Mohd Yusran , Blair Sally , Nah Shireen A. , Ariffin Hany , Assanasen Chatchawin , Soh Shui Yen , Jacobsen Anette S. , Lam Catherine , Loh Amos H. P. 
Published: September 2020

PURPOSEPediatric solid tumors require coordinated multidisciplinary specialist care. However, expertise and resources to conduct multidisciplinary tumor boards (MDTBs) are lacking in low- and middle-income countries (LMICs). We aimed to profile the landscape of pediatric solid tumor care and practices and perceptions on MDTBs among pediatric solid tumor units (PSTUs) in Southeast Asian LMICs.METHODSUsing online surveys, availability of specialty manpower and MDTBs among PSTUs was first determined. From the subset of PSTUs with MDTBs, one pediatric surgeon and one pediatric oncologist from each center were queried using 5-point Likert scale questions adapted from published questionnaires.RESULTSIn 37 (80.4%) of 46 identified PSTUs, availability of pediatric-trained specialists was as follows: oncologists, 94.6%; surgeons, 91.9%; radiologists, 54.1%; pathologists, 40.5%; radiation oncologists, 29.7%; nuclear medicine physicians, 13.5%; and nurses, 81.1%. Availability of pediatric-trained surgeons, radiologists, and pathologists was significantly associated with the existence of MDTBs ( P = .037, .005, and .022, respectively). Among 43 (89.6%) of 48 respondents from 24 PSTUs with MDTBs, 90.5% of oncologists reported > 50% oncology-dedicated workload versus 22.7% of surgeons. Views on benefits and barriers did not significantly differ between oncologists and surgeons. The majority agreed that MDTBs helped to improve accuracy of treatment recommendations and team competence. Complex cases, insufficient radiology and pathology preparation, and need for supplementary investigations were the top barriers.CONCLUSIONThis first known profile of pediatric solid tumor care in Southeast Asia found that availability of pediatric-trained subspecialists was a significant prerequisite for pediatric MDTBs in this region. Most PSTUs lacked pediatric-trained pathologists and radiologists. Correspondingly, gaps in radiographic and pathologic diagnoses were the most common limitations for MDTBs. Greater emphasis on holistic multidisciplinary subspecialty development is needed to advance pediatric solid tumor care in Southeast Asia.
‘Reassembled resemblings’ of teachers’ learning practices with Twitter
Authors: Guest Ian Fraser 
Published: September 2020

AbstractSome teachers claim Twitter has become a useful source for their professional development and learning. As a social media platform, Twitter constitutes a heterogeneous ensemble of humans and things. However, research has yet to allow the nonhuman participants in Twitter to speak for themselves, reveal what they do and present the webs of relations that they enact. I offer here an approach to address that issue by drawing upon actor-network theory and interviewing objects, whilst evoking the spirit of the Parisian flâneur. I begin by untangling a tweet to identify each of the human and nonhuman actors, what they do and how they assist in performing teachers’ learning activities. I then ‘Gather Anecdotes’ describing how two other heuristics – ‘Following the Actors’ and ‘Studying Breakdowns’ – were appropriate for this study, how they were deployed, what fresh knowledge they produced and how a new research avenue was opened. I conclude by reflecting on some of the tensions which emerged when bringing a sociomaterial analysis to teachers’ practices.
Tahlīlu al-Ahktā’i al-Kitābīyyati Fī Darsi al-Imlā’ litilmīżāti al-Fashli al-Awwali Fī al-Madrasati al-Mutawasiţati ma’hadi tahfīẓi al-Qur’ān bi ma’hadi al-Amīni Al-Islāmiyya Prenduan
Authors: Luthfatul Qibtiyah  , Lindawati  
Published: September 2020

Problem analysis is the process of identifying and interpreting linguistic problem made by students when learning a foreign language as a second language. Linguistic problem was found in all language skills, including writing skills. In practice, many students were doing some mistakes in writing as like morphological problem, syntax, and dictation. The purpose of this study is to analyze the forms of Imla problem and the causes of imla problem for students in 1st grade of Ma'had Tahfidz Al-Qur'an Al-Amien Prenduan Middle School and solutions to overcome these problems. This research is qualitative research, with a descriptive-analytic evaluative type. Data collection methods used were documentation and interviews. The data sources were documentation of the writing of 1st grade student of Ma'had Tahfidz Al-Qur'an Al-Amien Prenduan Middle School, imla instructor, and 1st grade student of Ma'had Tahfidz Al-Qur'an Al-Amien Prenduan. Data analysis techniques used in this study were data collection, problem identification, problem classification, problem explanation, and problem evaluation. The results of this study in imla writing problem were writing hamzah washal and qath'i, lam syamsiyah and qomariyah, alif layyinah, and tanwin fathah. While there were two factors for the occurrence of imla writing problems: 1) Internal factors: lack of understanding of the imla theory, poor hearing, unfocused, poor of mufradat, and unable to distinguish letters, long and short. 2) External factors: unfavorable classroom conditions, teacher dictation, unclear teacher's voice and the teacher's explanation of the imla theory were not detailed. The effective solution to reduce these problems is Ishlah Mubasyir (direct improvement) and repeat the explaination for the wrong material.
Keywords: Writing Problem Analysis, Imla
Maximum Entropy Analysis of Consumption-based Capital Asset Pricing Model and Volatility
Authors: Lee Tae-Hwy , Mao Millie Yi , Ullah Aman 
Published: September 2020

Abstract
Based on the maximum entropy (ME) method, we introduce an information theoretic approach to estimating conditional moment functions with incorporating a theoretical constraint implied from the consumption-based capital asset pricing model (CCAPM). Using the ME conditional mean/variance functions obtained from the ME density, we analyze the relationship between asset returns and consumption growth under the theoretical constraint of the CCAPM. We evaluate the predictability of asset return using consumption growth through in-sample estimation and out-of-sample prediction in the ME mean regression function. We also examine the ME variance regression function for the asset return volatility as a function of the consumption growth. Our findings suggest that incorporating the CCAPM constraint can capture the nonlinear predictability of asset returns in mean especially in tails, and that the consumption growth has an effect on reducing stock return volatility, indicating the counter-cyclical variation of stock market volatility.
Activation of Subthalamic Nucleus Stop Circuit Disrupts Cognitive Performance
Authors: Heston Jonathan , Friedman Alexander , Baqai Mustafa , Bavafa Nicholas , Aron Adam R. , Hnasko Thomas S. 
Published: September 2020

AbstractMuch evidence supports a fundamental role for the subthalamic nucleus (STN) in rapidly stopping behavior when a stop signal or surprising event occurs, but the extent to which the STN may be involved in stopping cognitive processes is less clear. Here, we used an optogenetic approach to control STN activity in a delayed-match-to-position (DMTP) task where mice had to recall a response location after a delay. We first demonstrated that a surprising event impaired performance by both slowing the latency to respond and increasing the rate of errors. We next showed that these effects could be mimicked by brief optogenetic activation of the STN. Further, inhibiting STN during surprise blocked surprise-induced slowing, although without changing surprise-induced errors. These data are consistent with the hypothesis that STN is recruited by surprise to slow responding and that this can also interrupt cognitive processes. Under normal conditions STN-mediated stopping of behavior may slow or stop ongoing cognition to facilitate cognitive reorienting and adaptive responses to unexpected sensory information, but when malfunctioning, it could produce pathologies related to over-rigidity or increased distractibility.
Astragaloside IV alleviates placental oxidative stress and inflammation in GDM mice
Authors: Zhou Ling , Zhang Ruixue , Yang Shuangyan , Zhang Yaguang , Shi Dandan 
Published: September 2020

Background:
Our previous study revealed that astragaloside IV (AS-IV) effectively improved gestational diabetes mellitus (GDM) by reducing hepatic gluconeogenesis. Due to the importance of placental oxidative stress, we further explored the protective role of AS-IV on placental oxidative stress in GDM.

Methods:
First, non-pregnant mice were orally administrated with AS-IV to evaluate its safety and effect. Then GDM mice were orally administered with AS-IV for 20 days and its effect on the symptoms of GDM, placental oxidative stress, secretions of inflammatory cytokines, as well as toll-like receptor 4 (TLR4)/NF-κB signaling pathway, were evaluated.

Results:
AS-IV had no adverse effect on non-pregnant mice. On the other hand, AS-IV significantly attenuated the GDM-induced hyperglycemia, glucose intolerance, insulin resistance, placental oxidative stress, productions of inflammatory cytokines and the activation of TLR4/NF-κB pathway.

Conclusion:
AS-IV effectively protected against GDM by alleviating placental oxidative stress and inflammation, in which TLR4/NF-κB might be involved.
Elicitación de una distribución a priori para el modelo logístico
Authors: Tangarife Quintero Jenny Andrea , Correa Morales Juan Carlos 
Published: September 2020

En muchas situaciones resulta util cuanticar informacion subjetiva que uno o varios expertos conocen acerca de un tema de interes, por esto, una parte importante dentro de la estadstica Bayesiana es la construccion de metodos de elicitacion para hallar distribuciones de probabilidad. Con el fin de contribuir al desarrollo en este campo,se desarrollo una metodología para elicitar los parametros de la regresion logstica con una sola covariable. El metodo que se plantea requiere que se jen unos niveles de la covarible y en estos se asume una distribucion Binomial, para cada nivel se elicita el parametro de interes mediante la metodologa indirecta de muestras hipoteticas.
Biblia e iglesia, a la luz de la Lumen Gentium
Authors: Vergara Abril Ana Francisca 
Published: September 2020

En este artículo de reflexión se presenta un acercamiento a la constitución dogmática Lumen Gentium del Concilio Vaticano II desde un horizonte bíblico, se divide en tres grandes apartados en los cuales se presentan diferentes visiones del concepto ‘iglesia’, a saber: biblia e iglesia, las imágenes bíblicas de la iglesia y de una pastoral de mera conservación a una pastoral decididamente misionera; el texto parte desde una conceptualización especializada para terminar en la labor evangelizadora y pastoral.