bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing Interlimb Jump Asymmetry in Young Soccer Players: The My Jump 2 App
Authors: Barbalho Matheus , Kleiner Ana Francisca Rozin , Callegari Bianca , de Lima Ramon Costa , da Silva Souza Givago , de Athayde Costa e Silva Anselmo , Coswig Victor Silveira 
Published: October 2020

Background:Jumps are important evaluation tools for muscle strength and power and for interlimb asymmetries. Different jump tests are well related to athletic performance, prediction of injury risk, and common motor gestures of several sports such as soccer. Low-cost mobile applications (apps) have gained popularity for this measure. The authors hypothesized that the My Jump 2 app would be a valid tool to assess drop-jump performance and interlimb asymmetry in soccer players.Methods:Eleven male soccer players took part in this study (18.2 [1.3] y, 69.9 [9.5] kg, 174 [6.6] cm). The athletes performed each test twice on a force plate (gold-standard method), while the jumps were recorded through the mobile app. Measures with the My Jump 2 app were applied by 2 evaluators, independently and in duplicate (interrater and intrarater reliability). The agreement analysis between both evaluations was done using an intraclass correlation coefficient and Bland–Altman plots.Results:Compared with the force platform, the app tested showed excellent reliability for the drop jump’s flight time and interlimb asymmetry (intraclass correlation coefficient > .98). For interlimb contact-time asymmetry, the values were 18.4 (9.9) and 19.1 (9.9) milliseconds for the My Jump 2 app and the force platform, respectively (P = .88). For flight-time asymmetries, the values were 389.7 (114.3) and 396.8 (112.5) milliseconds for the My Jump 2 app and the force platform, respectively (P = .88).Conclusion:The My Jump 2 app is a valid tool to assess drop-jump and interlimb asymmetry in soccer players.
Electric Breakdown in Long Discharge Tubes at Low Pressure (Review)
Authors: Ionikh Yu. Z. 
Published: October 2020

AbstractThe review is devoted to studies of the processes and mechanisms of ignition of a glow discharge in tubes whose length significantly exceeds their diameter (long discharge tubes) at low pressures (~10 Torr and lower) and moderate voltage rise rates (~1 kV/μs and lower). The electric field in such tubes before a breakdown is substantially nonuniform. Therefore, a breakdown occurs after an ionization wave (or waves) passes through the discharge gap at a speed of ~105–107cm/s. This makes the characteristics of the breakdown in long tubes significantly different from the breakdown between large and closely spaced electrodes, where the electric field is uniform before the breakdown and where the Townsend or, under strong overvoltage, streamer mechanism is realized. On the other hand, the nature of these processes is very different from those occurring in nanosecond discharges, which arise at voltages with a steepness of ~1 kV/ns and higher and are associated with high-speed (~109cm/s) ionization waves. The review is based on the materials of experimental and computational works published from 1938 to 2020. Breakdown processes, optical and electrical characteristics of the discharge gap during breakdown, and the influence of the external circuit parameters and external actions (shielding and illumination by external sources of visible radiation) are analyzed.
What are important consequences in children with non-specific spinal pain? A qualitative study of Danish children aged 9–12 years
Authors: Lauridsen Henrik Hein , Stolpe Anna Bjellekjær , Myburgh Cornelius , Hestbæk Lise 
Published: October 2020

ObjectivesIt is currently unknown whether children, adolescents and adults experiencing non-specific spinal pain are affected by their pain in a similar manner. It is also unclear whether questionnaires developed for adults can simply be transferred to paediatric populations. The objective of this study was to explore the physical, psychological and social consequences of a life with non-specific spinal pain among Danish children and to compare these consequences with the content of common adult questionnaires.Design and settingA qualitative study based on individual interviews and focus group discussions with participants recruited from two public schools in Denmark.ParticipantsThirty-six children aged 9–12 years with spinal pain were invited to an interview using a purposive sampling strategy with age, pain intensity and frequency, and general well-being status as inclusion criteria. Nineteen (9 girls, 10 boys) accepted to participate.MethodsData were transcribed verbatim and coded by following a thematic approach to elicit key concepts relevant to spinal pain. Subsequently, focus group interviews were conducted, and all codes were assigned categories corresponding to the International Classification of Function, Disability and Health (ICF) for comparison to adult questionnaires.ResultsNineteen interviews were included, and 21 individual codes identified. Across the codes, five themes emerged in relation to children’s experiences of living with spinal pain: ‘Sports and play’, ‘Axial loading’, ‘Coping strategies’, ‘Mood changes’ and ‘Pain anxiety’. Codes and themes were elaborated on by the focus groups. Only approximately 40% of the identified ICF categories were covered by adult spinal questionnaires.ConclusionsThe negative impact of non-specific spinal pain on children aged 9–12 years pivots around codes which are considerably different to adults. Psychological and social factors were more prominent and pain anxiety was dominant in the lived lives of children. New questionnaires should be age specific and include the identified codes within each theme.
Protocol for a scoping review to understand what is known about how GPs make decisions with, for and on behalf of patients who lack capacity
Authors: Ogden Simon Jack , Huxtable Richard , Ives Jonathan 
Published: October 2020

IntroductionGeneral Practitioners (GPs) and allied healthcare professionals working in primary care are regularly required to make decisions with, for and on behalf of patients who lack capacity. In England and Wales, these decisions are made for incapacitated adult patients under the Mental Capacity Act 2005, which primarily requires that decisions are made in the patient’s ‘best interests’. Regarding children, decisions are also made in their best interests but are done so under the Children Act 1989, which places paramount importance on the welfare of the child. Decisions for children are usually made by parents, but a GP may become involved if he or she feels a parent is not acting in the best interests of the child. Internationally, including elsewhere in the UK, different approaches are taken. We hypothesise that, despite the legislation and professional guidelines, there are many different approaches taken by GPs and allied healthcare professionals in England and Wales when making these complex decisions with, for and on behalf of patients who lack capacity. To better understand what is known about how these decisions are made, we plan to undertake a scoping review and directed content analysis of the literature. While the majority of decisions made in primary care are made by GPs, for completeness, this review will include all allied healthcare professionals working in primary care.Methods and analysisTo ensure a wide breadth of literature is captured, a scoping review will be undertaken as described by Arksey and O’Malley (2005). A five-stage approach will be taken when conducting this review: (1) identifying the research question; (2) identifying relevant papers; (3) study selection; (4) data extraction and (5) summarising and synthesis. The final stage will include a directed content analysis of the data to help establish the cross-cutting themes.Ethics and disseminationThe scoping review will be disseminated through conferences and peer-reviewed publications. This scoping review is the first (mapping) phase in a proposed larger study to explore how GPs make decisions with, for and on behalf of those who lack capacity. Qualitative research with GPs, patients and their families will follow, before all the results are synthesised using an ‘empirical bioethics’ methodology.
SUFE and the internet: are healthcare information websites accessible to parents?
Authors: Mc Carthy Andrea , Taylor Colm 
Published: October 2020

BackgroundSlipped upper femoral epiphysis is an adolescent hip disorder requiring rapid surgical intervention. Faced with the prospect of their child undergoing surgery, many fearful parents will turn to the internet to provide information and reassurance. Previous studies have shown the orthopaedic information can be difficult to comprehend.ObjectiveAssess the readability of healthcare websites regarding slipped upper femoral epiphysis.MethodsThe term Slipped Upper Femoral Epiphysis was searched in Google, Bing and Yahoo. The websites were evaluated using readability software with seven specialised readability tests including the Flesch-Kincaid Reading Grade Level, the Flesch Reading Ease Score, the Simple Measure of Gobbledygook, Coleman-Liau Index, Automated Readability Index and the Gunning Fog Index. The reading grade level (RGL) was also calculated.A Flesich Read Ease Score (FRES) score above 65 and an RGL of sixth grade and under was considered acceptable. Websites were also assessed for translation services.Results21 unique websites were assessed. The average FRES was 52.5±15.4. Only 3 websites scored 65 or higher (14%). There was a statistically significant difference between website scores based on affiliation, with physician websites having the overall highest mean(p=0.004).The average RGL was 8.67±1.8. Only two websites met the accepted RGL criteria (9.5%) while five websites were marked as extremely difficult to understand (23.8%). Only five websites offered translations (23.8%). There was no statistically significant difference in readability scores between websites which offered translation and those which did not.One-sample t-tests showed that both the RGL (p<0.001; CI 1.83 to 3.49) and the FRES (p<0.001, CI −19.4 to −5.4) scores were significantly different from the accepted standard.ConclusionMost websites reviewed were above the recommended RGL, making content inaccessible. Improving readability and translation services would enhance the internet’s usability as a healthcare tool for parents.
Income level and outcomes in patients with heart failure with universal health coverage
Authors: Hung Chung-Lieh , Chao Tze-Fan , Su Cheng-Huang , Liao Jo-Nan , Sung Kuo-Tzu , Yeh Hung-I , Chiang Chern-En 
Published: October 2020

ObjectiveWe aimed to investigate the influence of income level on guideline-directed medical therapy (GDMT) prescription rates and prognosis of patients with heart failure (HF) following implementation of a nationwide health insurance programme.MethodsA total of 633 098 hospitalised patients with HF from 1996 to 2013 were identified from Taiwan National Health Insurance Research Database. Participants were classified into low-income, median-income and high-income groups. GDMT utilisation, in-hospital mortality and postdischarge HF readmission, and mortality rates were compared.ResultsThe low-income group had a higher comorbidity burden and was less likely to receive GDMT than the other two groups. The in-hospital mortality rate in the low-income group (5.07%) was higher than in the median-income (2.47%) and high-income (2.51%) groups. Compared with the high-income group, the low-income group had a significantly higher risk of postdischarge HF readmission (adjusted HR (aHR): 1.29, 95% CI 1.27 to 1.31), all-cause mortality (aHR: 1.98, 95% CI 1.95 to 2.02) and composite HF readmission/all-cause mortality (aHR: 1.54, 95% CI 1.52 to 1.56). These results were generally consistent among the population after propensity matching (low vs high: HR=2.08 for mortality and 1.36 for HF readmission; median vs high: HR=1.23 for mortality and 1.12 for HF readmission; all p<0.001) and after inverse probability of treatment weighting (low-income vs high-income group: HR: 2.19 for mortality and 1.16 for HF readmission; median-income vs high-income group: HR: 1.53 for mortality and 1.09 for HF readmission; all p<0.001). Lower utilisation of GDMT and poorer prognosis in lower-income hospitalised patients with HF appeared to mitigate over time.ConclusionsLow-income patients with HF had nearly a twofold increase in the risk of in-hospital mortality and postdischarge events compared with the high-income group, partly due to lower GDMT utilisation. The differences between postdischarge HF outcomes among various income groups appeared to mitigate over time following the implementation of nationwide universal health coverage.
Newly diagnosed diabetes and outcomes after acute myocardial infarction in young adults
Authors: Ding Qinglan , Spatz Erica S , Lipska Kasia J , Lin Haiqun , Spertus John A , Dreyer Rachel P , Whittemore Robin , Funk Marjorie , Bueno Hector , Krumholz Harlan M 
Published: October 2020

ObjectiveTo examine prevalence and characteristics of newly diagnosed diabetes (NDD) in younger adults hospitalised with acute myocardial infarction (AMI) and investigate whether NDD is associated with health status and clinical outcomes over 12-month post-AMI.MethodsIn individuals (18–55 years) admitted with AMI, without established diabetes, we defined NDD as (1) baseline or 1-month HbA1c≥6.5%; (2) discharge diabetes diagnosis or (3) diabetes medication initiation within 1 month. We compared baseline characteristics of NDD, established diabetes and no diabetes, and their associations with baseline, 1-month and 12-month health status (angina-specific and non-disease specific), mortality and in-hospital complications.ResultsAmong 3501 patients in Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients study, 14.5% met NDD criteria. Among 508 patients with NDD, 35 (6.9%) received discharge diagnosis, 91 (17.9%) received discharge diabetes education and 14 (2.8%) initiated pharmacological treatment within 1 month. NDD was more common in non-White (OR 1.58, 95% CI 1.23 to 2.03), obese (OR 1.72, 95% CI 1.39 to 2.12), financially stressed patients (OR 1.27, 95% CI 1.02 to 1.58). Compared with established diabetes, NDD was independently associated with better disease-specific health status and quality of life (p≤0.04). No significant differences were found in unadjusted in-hospital mortality and complications between NDD and established or no diabetes.ConclusionsNDD was common among adults≤55 years admitted with AMI and was more frequent in non-White, obese, financially stressed individuals. Under 20% of patients with NDD received discharge diagnosis or initiated discharge diabetes education or pharmacological treatment within 1 month post-AMI. NDD was not associated with increased risk of worse short-term health status compared with risk noted for established diabetes.Trial registration numberNCT00597922.
Long-term safety and efficacy of distal aneurysm treatment with flow diversion in the M2 segment of the middle cerebral artery and beyond
Authors: Cimflova Petra , Özlük Enes , Korkmazer Bora , Ahmadov Ramiz , Akpek Elif , Kizilkilic Osman , Islak Civan , Kocer Naci 
Published: October 2020

BackgroundIndications for flow diversion stent (FDS) treatment are expanding. However, there is still a lack of evidence for the long-term outcome in distally located aneurysms in the M2 segment of the middle cerebral artery (MCA) and beyond.MethodsConsecutive subjects (from June 2013 to August 2020) with MCA aneurysms in the M2 segment or beyond treated with FDS were reviewed retrospectively. The primary endpoints for clinical safety were the absence of mortality, stroke event, re-rupture of the aneurysm, and worsening of clinical symptoms. The primary endpoint for treatment efficacy was complete/near-complete occlusion at follow-up after 12 months.Results23 patients were identified: 7 aneurysms were located in the M2 segment of the MCA, 4 in the M2-M3 bifurcation, 2 in M3, 3 in M3-4 branching, and 2 in M4; 5 aneurysms were located in M2 with extension into the M1-M2 bifurcation. 13 aneurysms were of fusiform morphology, 8 sacculofusiform, and 2 saccular. 16 aneurysms were of highly suspected dissecting etiology. The median diameter of the parent vessel was 2.1 mm proximally and 2 mm distally. The median time of the follow-up was 30 months (range 16 months to 6 years). Complete/near complete occlusion was observed in 14/20 patients (70%) and one stable remodeling (5%) was seen at 12 months. 22 patients (95.6%) had an excellent clinical outcome (mRS 0–1) at 6 months. Technical challenges associated with the deployment of FDS occurred in 8.7% of cases. Severe complications, intraparenchymal hemorrhage and re-rupture of the aneurysm occurred in 2 patients (8.7%).ConclusionFlow diversion of distally located aneurysms is technically feasible with low morbidity and mortality.
Acute hyperaminoacidemia does not suppress insulin-mediated glucose turnover in healthy young men
Authors: Burgos Sergio A. , Chevalier Stéphanie , Morais José A. , Lamarche Marie , Kellett Samantha , Marliss Errol B. 
Published: October 2020

Elevated circulating amino acids (AA) concentrations are purported to cause insulin resistance (IR) in humans. To quantify hyperaminoacidemia effects on insulin-mediated glucose turnover in healthy men, we performed 2-stage pancreatic clamps using octreotide with glucagon and growth hormone replacement. In the basal stage, insulin was infused to maintain euglycemia at postabsorptive levels. During the clamp stage, insulin was raised to postprandial levels, glycemia clamped at 5.5 mmol/L by glucose infusion, and branched-chain AA (BCAA) maintained at either postabsorptive (Hyper1; n = 8) or postprandial (Hyper2; n = 7) by AA infusion. Glucose turnover was measured by d-3-[3H]glucose dilution. Octreotide suppressed C-peptide; glucagon, growth hormone, and glycemia were maintained at postabsorptive levels throughout. Insulin did not differ at postabsorptive (72 ± 5 vs. 60 ± 5 pmol/L; Hyper1 vs. Hyper2) and increased to similar concentrations at basal (108 ± 11 vs. 106 ± 14) and clamp stages (551 ± 23 vs. 540 ± 25). Postabsorptive BCAA were maintained during Hyper1 and increased >2-fold (830 ± 26 µmol/L) during Hyper2. Endogenous glucose production was similarly suppressed (0.95 ± 0.16 vs. 1.37 ± 0.23 mg/kg lean body mass/min; Hyper1 vs. Hyper2) and basal glucose disposal (3.44 ± 0.12 vs. 3.67 ± 0.14) increased to similar levels (10.89 ± 0.56 vs. 11.11 ± 1.00) during the clamp. Thus, acute physiological elevation of AA for 3 h did not cause IR in healthy men. Novelty: A 2-step pancreatic clamp was used to quantify the effect of AA on insulin sensitivity in humans. Acute physiological elevation of circulating AA to postprandial levels does not cause IR in healthy men.
Inhomogeneous compact extra dimensions and de Sitter cosmology
Authors: Bronnikov Kirill A. , Popov Arkady A. , Rubin Sergey G. 
Published: October 2020

AbstractIn the framework of multidimensional f(R) gravity, we study the possible metrics of compact extra dimensions assuming that our 4D space has the de Sitter metric. Manifolds described by such metrics could be formed at the inflationary and even higher energy scales. It is shown that in the presence of a scalar field, it is possible to obtain a variety of inhomogeneous metrics in the extra factor space $${{\mathbb {M}}}_2$$

M
2

. Each of these metrics leads to a certain value of the 4D cosmological constant $$\varLambda _4$$

Λ
4

, and in particular, it is possible to obtain $$\varLambda _4 =0$$

Λ
4

=
0

, as is confirmed by numerically obtained solutions. A nontrivial scalar field distribution in the extra dimensions is an important feature of this family of metrics. The obtained solutions are shown to be stable under extra-dimensional perturbations.
Soluble Receptor for Advanced Glycation End-products (sRAGE) and Colorectal Cancer Risk: A Case–Control Study Nested within a European Prospective Cohort
Authors: Aglago Elom K. , Rinaldi Sabina , Freisling Heinz , Jiao Li , Hughes David J. , Fedirko Veronika , Schalkwijk Casper G. , Weiderpass Elisabete , Dahm Christina C. , Overvad Kim , Eriksen Anne Kirstine , Kyrø Cecilie , Boutron-Ruault Marie-Christine , Rothwell Joseph A. , Severi Gianluca , Katzke Verena , Kühn Tilman , Schulze Matthias B. , Aleksandrova Krasimira , Masala Giovanna , Krogh Vittorio , Panico Salvatore , Tumino Rosario , Naccarati Alessio , Bueno-de-Mesquita Bas , van Gils Carla H. , Sandanger Torkjel M. , Gram Inger T. , Skeie Guri , Quirós J. Ramón , Jakszyn Paula , Sánchez Maria-Jose , Amiano Pilar , Huerta José María , Ardanaz Eva , Johansson Ingegerd , Harlid Sophia , Perez-Cornago Aurora , Mayén Ana-Lucia , Cordova Reynalda , Gunter Marc J. , Vineis Paolo , Cross Amanda J. , Riboli Elio , Jenab Mazda 
Published: October 2020

Abstract

Background:
Overexpression of the receptor for advanced glycation end-product (RAGE) has been associated with chronic inflammation, which in turn has been associated with increased colorectal cancer risk. Soluble RAGE (sRAGE) competes with RAGE to bind its ligands, thus potentially preventing RAGE-induced inflammation.

Methods:
To investigate whether sRAGE and related genetic variants are associated with colorectal cancer risk, we conducted a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). Plasma sRAGE concentrations were measured by ELISA in 1,361 colorectal cancer matched case–control sets. Twenty-four SNPs encoded in the genes associated with sRAGE concentrations were available for 1,985 colorectal cancer cases and 2,220 controls. Multivariable adjusted ORs and 95% confidence intervals (CIs) were computed using conditional and unconditional logistic regression for colorectal cancer risk and circulating sRAGE and SNPs, respectively.

Results:
Higher sRAGE concentrations were inversely associated with colorectal cancer (ORQ5vs.Q1, 0.77; 95% CI, 0.59–1.00). Sex-specific analyses revealed that the observed inverse risk association was restricted to men (ORQ5vs.Q1, 0.63; 95% CI, 0.42–0.94), whereas no association was observed in women (ORQ5vs.Q1, 1.00; 95% CI, 0.68–1.48; Pheterogeneity for sex = 0.006). Participants carrying minor allele of rs653765 (promoter region of ADAM10) had lower colorectal cancer risk (C vs. T, OR, 0.90; 95% CI, 0.82–0.99).

Conclusions:
Prediagnostic sRAGE concentrations were inversely associated with colorectal cancer risk in men, but not in women. An SNP located within ADAM10 gene, pertaining to RAGE shedding, was associated with colorectal cancer risk.

Impact:
Further studies are needed to confirm our observed sex difference in the association and better explore the potential involvement of genetic variants of sRAGE in colorectal cancer development.