bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of concomitant obstructive sleep apnea on pulmonary involvement and main pulmonary artery diameter in adults with scleroderma
Authors: Yakut Tugce , Balcan Baran , Karakurt Sait , Direskeneli Haner , Yalcinkaya Yasemin , Peker Yüksel 
Published: April 2020

AbstractPurposePulmonary involvement is common in adults with scleroderma. The effect of concomitant obstructive sleep apnea (OSA) on risk for pulmonary hypertension in scleroderma is unknown. An enlarged main pulmonary artery diameter (mPAD) derived from chest computer tomography (CT) is a useful predictor of pulmonary hypertension. We addressed the effect of OSA on pulmonary involvement and enlarged mPAD in adults with scleroderma.MethodsAll participants underwent pulmonary function testing, carbon monoxide diffusion capacity, chest CT, and overnight sleep recording with home sleep apnea testing. OSA diagnosis was based on an apnea-hypopnea index (AHI) ≥ 15/h. Oxygen desaturation index (ODI) was also recorded. Scleroderma involvement of the lungs was defined as the Warrick score ≥ 7 based on the CT findings. Enlarged mPAD was defined as an mPAD ≥ 29 mm in men and ≥ 27 mm in women.ResultsAfter exclusions, 62 patients (58 women) were included. OSA was found among 20 (32%), 17/42 (38%) in the limited cutaneous type, and 3/20 (15%) in the diffuse cutaneous type (p= 0.08). Scleroderma involvement of the lungs was observed in 40 participants (65% in OSA vs 64% in no-OSA; n.s.). Enlarged mPAD was measured in 16 participants, 10 of 20 (50%) in the OSA group and 6 of 17 (14%) in the no-OSA group (p= 0.003). OSA was associated with enlarged mPAD (odds ratio 4.7, 95% confidence interval 1.1–20.9;p= 0.042) independent of age, body mass index, and pulmonary involvement. There was a linear relationship between mPAD and AHI (r= 0.37;p= 0.003) as well as ODI (r= 0.41;p< 0.001).ConclusionsIn this cohort, OSA was associated with risk for pulmonary hypertension independent of pulmonary involvement. These findings suggest that assessing the effect of therapy for concomitant OSA in patients with scleroderma is warranted.Trial registrationNCT 02740569
Reporting Clinical Significance in Hip Arthroscopy: Where Are We Now?
Authors: Polascik Breanna A. , Peck Jeffrey , Cepeda Nicholas , Lyman Stephen , Ling Daphne 
Published: April 2020

Background Although p values are standard for reporting statistical significance of patient-reported outcome measures (PROMs), the shift toward clinically important outcome values, including minimal clinically important difference (MCID) and substantial clinical benefit (SCB), necessitates re-evaluation of the current literature. Questions/Purposes We sought to answer two questions regarding studies on primary hip arthroscopy performed for the treatment of femoroacetabular impingement syndrome (FAIS). (1) Do such studies reporting statistical significance on common PROMs meet published MCID/SCB thresholds? (2) What proportion of such studies report both statistical and clinical significance? Methods We identified four papers published in two journals defining MCID/SCB values on the modified Harris Hip Score (mHHS), Hip Outcome Score–Activities of Daily Living (HOS-ADL), Hip Outcome Score-Sport (HOS-Sport), international Hip Outcome Tool (iHOT-33), and its short version (iHOT-12) for different groups of FAIS patients undergoing hip arthroscopy. We reviewed these two journals from the dates of publication to the present to identify papers reporting changes in post-operative PROMs. The difference in pre- and post-operative scores on each PROM was calculated and compared to MCID/SCB thresholds. Results Twelve studies were included. Ten studies (83%) evaluated mHHS (90% met MCID, 50% met SCB), seven (58%) evaluated HOS-ADL (100% met MCID/SCB) and HOS-Sport (100% met MCID, 57% met SCB), and one (8%) evaluated iHOT-33 (met MCID/SCB) and iHOT-12 (met MCID). Most studies met MCID and SCB at both 1- and 2-year timepoints. Of the studies evaluated, 50% reported clinical relevance. Conclusions Nearly all studies evaluated met MCID, while fewer met SCB. Only half discussed these clinical measures. It is proposed that all future studies report both statistical and clinical significance as standard best practice.
The Nature of Native MgO in Mg and Its Alloys
Authors: Wang Shihao , Wang Yun , Ramasse Quentin , Fan Zhongyun 
Published: April 2020

AbstractNative MgO particles in Mg-alloy melts have been recently exploited as potential substrates for heterogeneous nucleation during solidification, leading to significant grain refinement of various Mg-alloys. However, our current knowledge of the nature of the native MgO particles is still limited. In this work, we study both the physical and chemical nature of the native MgO in commercial purity Mg and Mg-9Al alloy by means of advanced electron microscopy. We found that as oxidation products MgO aggregates exist in the alloy melt in three different forms: dominantly young oxide film, occasionally old oxide film and ingot skin, all consisting of discrete nano-sized MgO particles. Detailed analysis shows that the native MgO particles have an octahedral or cubic morphology, a nano-scale particle size and a log-normal size distribution. The mechanisms underlying the formation of the two types of MgO were investigated, and we found that octahedral MgO is formed by oxidation of Mg melt and cubic MgO by oxidation of Mg vapor. With a large lattice misfit withα-Mg, the native MgO particles are impotent for heterogeneous nucleation, but can be made effective for grain refinement.
Are aesthetic judgements purely aesthetic? Testing the social conformity account
Authors: Inglis Matthew , Aberdein Andrew 
Published: April 2020

AbstractMany of the methods commonly used to research mathematical practice, such as analyses of historical episodes or individual cases, are particularly well-suited togeneratingcausal hypotheses, but less well-suited totestingcausal hypotheses. In this paper we reflect on the contribution that the so-called hypothetico-deductive method, with a particular focus on experimental studies, can make to our understanding of mathematical practice. By way of illustration, we report an experiment that investigated how mathematicians attribute aesthetic properties to mathematical proofs. We demonstrate that perceptions of the aesthetic properties of mathematical proofs are, in some cases at least, subject to social influence. Specifically, we show that mathematicians’ aesthetic judgements tend to conform to the judgements made by others. Pedagogical implications are discussed.
Spatial and temporal variability of soil loss in gully erosion in upper Blue Nile basin, Ethiopia
Authors: Bogale Alemsha , Aynalem Dessalew , Adem Anwar , Mekuria Wolde , Tilahun Seifu 
Published: April 2020

AbstractGully erosion has many negative impacts on both cultivated and grazing lands in Ethiopian highlands. The present study was conducted in Chentale watershed, Ethiopia, to quantify the contribution of gully erosion, and to assess its temporal changes. Within the Chentale watershed, we selected a sub-watershed (104.6 ha) and nested gully catchment, and gauged for stream flow and sediment concentration data in 2015 and 2016. We measured gully dimensions before and after the onset of the rainy season in 2016 to determine soil loss due to gully erosion. The temporal changes of gully expansion were determined by digitizing gully plain area from Google earth images taken in 2005 and 2013. The results support that gullies were expanding at higher rate in recent years. Area covered by gullies in the watershed increased from 1.84 to 3.43 ha between 2005 and 2013, indicating that the proportion of the watershed covered by gullies was nearly doubled in the investigated period. The estimated soil loss from the main watershed and gullies catchment was 6 and 2 t ha−1 year−1 in 2015, and was 7 and 9 t ha−1 year−1 in 2016, respectively. The results support that gullies were the main contributors of soil erosion in the watershed, and that integrated soil and water conservation measures are required to reduce soil erosion.
Effect of the specific surface area of MgO on the treatment of boron and fluorine
Authors: Kameda Tomohito , Yamamoto Yusuke , Kumagai Shogo , Yoshioka Toshiaki 
Published: April 2020

AbstractTo realize improved wastewater treatment processes, the study investigated the processing of boron and fluorine and the processing of real landfill leachate using MgO with different specific surface areas. By optimizing the MgO absorbent, the time required for boron and fluorine processing can be reduced dramatically and uniform wastewater quality standards can be achieved. The rate constants for boron and fluorine removal increased with both temperature and specific surface area. In the processing of actual wastewater, which contained many coexisting ions, MgO was successfully applied to the removal of boron.
Preventing healthcare-associated infection in Switzerland: Results of a national survey
Authors: Sax Hugo , Schreiber Peter W. , Clack Lauren , Ratz David , Saint Sanjay , Greene M. Todd , Kuster Stefan P. 
Published: April 2020

AbstractWe assessed infection prevention in Swiss hospitals via a national survey focusing on infection prevention practices prior to a large national infection prevention initiative. Of the 59 hospitals that responded (77%), 98% had infection prevention teams and 40% very good or excellent leadership support. However, a minority of hospitals used recommended infection prevention practices and surveillance systems regularly.
Covid-19 and the N95 respirator shortage: Closing the gap
Authors: Nogee Daniel , Tomassoni Anthony J. 
Published: April 2020

AbstractDue to extreme shortages of personal protective equipment caused by the COVID-19 pandemic, many healthcare workers will be forced to recycle protective masks intended for disposal after a single use. We propose investigating the use of ultraviolet germicidal irradiation to sterilize masks of SARS-CoV-2 for safer reuse.
Missing link: California rock crabs serve as intermediate hosts for the parasite Helicometrina nimia
Authors: Shanebeck K.M. , Presswell B. , Lagrue C. 
Published: April 2020

Abstract
Parasites can have strong effects on invertebrate host behaviour, fecundity and survival in marine ecosystems. However, parasites are often poorly documented and still rarely integrated into marine ecological modelling; comprehensive surveys of infection in marine invertebrates are sporadic at best. For example, rock crabs are an important part of Californian coastal ecosystems, both as regulators of mussel populations and non-native species, and as prey items for predators like sea otters, but their parasite communities and potential effects on crab population dynamics are seldom studied or understood. Here, we present the first report of infection by the trematode Helicometrina nimia in the economically and ecologically important red rock crab (Cancer productus) and Pacific rock crab (Romaleon antennarium). As intermediate hosts, they are a missing link for infection by H. nimia in Californian fish that was unreported until now. Based on these findings, we advocate for further research into parasite diversity and their potential effects on ecologically and commercially important species.
Energizing the plasmalemma of marine photosynthetic organisms: the role of primary active transport
Authors: Raven John A. , Beardall John 
Published: April 2020

AbstractGeneration of ion electrochemical potential differences by primary active transport can involve energy inputs from light, from exergonic redox reactions and from exergonic ATP hydrolysis. These electrochemical potential differences are important for homoeostasis, for signalling, and for energizing nutrient influx. The three main ions involved are H+, Na+(efflux) and Cl−(influx). In prokaryotes, fluxes of all three of these ions are energized by ion-pumping rhodopsins, with one archaeal rhodopsin pumping H+intothe cells; among eukaryotes there is also an H+influx rhodopsin inAcetabulariaand (probably) H+efflux in diatoms. Bacteriochlorophyll-based photoreactions export H+from the cytosol in some anoxygenic photosynthetic bacteria, but chlorophyll-based photoreactions in marine cyanobacteria do not lead to export of H+. Exergonic redox reactions export H+and Na+in photosynthetic bacteria, and possibly H+in eukaryotic algae. P-type H+- and/or Na+-ATPases occur in almost all of the photosynthetic marine organisms examined. P-type H+-efflux ATPases occur in charophycean marine algae and flowering plants whereas P-type Na+-ATPases predominate in other marine green algae and non-green algae, possibly with H+-ATPases in some cases. An F-type Cl−-ATPase is known to occur inAcetabularia. Some assignments, on the basis of genomic evidence, of P-type ATPases to H+or Na+as the pumped ion are inconclusive.
Age and growth of Antimora rostrata (Moridae, Gadiformes, Teleostei) from the Kerguelen and Crozet Islands in the southern Indian Ocean
Authors: Korostelev Nikolai B. , Vedishcheva Elena V. , Orlov Alexei M. 
Published: April 2020

AbstractAge and growth of blue antimora Antimora rostrata were examined for the first time in the waters of Kerguelen and Crozet Islands (southern Indian Ocean, sub-Antarctic). The longline catches were represented by fish ranging from 39 to 72 cm in total length with weights between 400 and 3310 g, aged 16– 41 years. A minimum age of 16 years was observed in a fish 39 cm long, while a maximum age of 41 years was recorded for an individual of 70 cm in length and 3310 g in weight. The age classes with the greatest numbers were represented by fish aged 34 years (9%), 28 years (9%) and 29 years (8%), which together accounted for 26% of the total catch. The blue antimora in the southern Indian Ocean shows similar growth rates to those of individual fish from the Ross, Lazarev and Weddell Seas and southeastern Greenland, which may indicate the population unity of the species within the Antarctic and sub-Antarctic waters or similar habitat conditions in these areas.
Cellular development of the germinal epithelium during the female and male gametogenesis of Chaetodon striatus (Perciformes: Chaetodontidae)
Authors: Bayona Perez Isabelle Leite , Mazzoni Talita Sarah , Quagio-Grassiotto Irani 
Published: April 2020

SummaryButterflyfish Chaetodon striatus is highly sought after in the marine ornamental aquarium, although studies about its reproductive biology are scarce. Therefore, to contribute to a better understanding of the reproductive aspects of C. striatus, we describe in detail with the use of high resolution histology the cellular dynamics of the germinal epithelium during the reproductive life history of this species. Based on the activity of the germinal epithelium, this study describes different stages of the gonadal development, similar to the reproductive phases found in other fish, to determine the reproductive period of C. striatus. In characterization of gonadal development, the following germ cells are described for males: spermatogonia, spermatocytes, spermatids and spermatozoa. Oogonia, early, primary, secondary, full-grown and maturing oocytes are described for females. Female germinal epithelium of C. striatus showed substantial changes over the study period, indicating that there was an active spawning period. Male germinal epithelium also presented relevant alterations, indicating reproductive activity in the testicular lobules. Morphological data confirm how informative was the cellular dynamics of the germinal epithelium for understanding gonadal development during adult reproductive life of fish in general. Although Chaetodon are a popular species, previous studies have only produced superficial and rough histological analyses. Therefore, this study demonstrates important information on germinal epithelium of Chaetodon. This knowledge could be a fundamental tool for development of new strategies for breeding of several species in captivity, especially butterflyfishes.
Fontan completion during winter season is not associated with higher mortality or morbidity in the early post-operative period
Authors: Nordmeyer Sarah , Krettek Sabeth , Nordmeyer Johannes , Schafstedde Marie , Rehm Konstantin , Photiadis Joachim , Berger Felix , Ovroutski Stanislav 
Published: April 2020

AbstractObjectives:The aim of our study was to compare post-operative outcome after total cavopulmonary connection between patients operated during winter and summer season.Methods:We retrospectively studied 211 patients who underwent extracardiac total cavopulmonary connection completion at our institution between 1995 and 2015 (median age 4 (1–42) years). Seventy (33%) patients were operated during winter (November to March) and 141 (67%) patients during summer season (April to October).Results:Patients operated during winter and summer season showed no difference in early mortality (7% versus 5%, p = 0.52) and severe morbidity like need for early Fontan takedown (1% versus 1%, p = 0.99) and need for mechanical circulatory support (9% versus 4%, p = 0.12). The post-operative course and haemodynamic outcome were comparable between both groups of patients (ICU (4 versus 3 days, p = 0.44) and hospital stay (15 versus 14 days, p = 0.28), prolonged pleural effusions (36% versus 31%, p = 0.51), need for dialysis (16% versus 11%, p = 0.37), ascites (37% versus 33%, p = 0.52), supraventricular tachyarrhythmia (16% versus 13%, p = 0.56) and chylothorax (26% versus 16%, p = 0.12), change of antibiotic treatment (47% versus 36%, p = 0.06), prolonged inotropic support (24% versus 14%, p = 0.05), intubation time (15 versus 12 hours, p = 0.33), and incidence of fast-track extubation (11% versus 22%, p = 0.06).Conclusion:Outcomes after total cavopulmonary connection completion during winter and summer season were comparably related to mortality, severe morbidity, or longer hospital stay in the early post-operative period. These results suggest that total cavopulmonary connection completion during winter season is as safe as during summer season.
A transition clinic intervention to improve follow-up rates in adolescents and young adults with congenital heart disease
Authors: Gaydos Stephanie S. , Chowdhury Shahryar M. , Judd Rochelle N. , McHugh Kimberly E. 
Published: April 2020

AbstractBackground:Children with congenital heart disease (CHD) require lifelong cardiology follow-up. Many experience gaps in care around the age of transition to adult-oriented care with associated comorbidity. We describe the impact of a clinic-based intervention on follow-up rates in this high-risk population.Methods:Patients ≥11 years seen in a paediatric outpatient CHD Transition Clinic completed self-assessment questionnaires, underwent focused teaching, and were followed on a clinic registry with assessment of care continuation. The cohort “lost to follow-up” rate, defined as absence from care at least 6 months beyond the recommended timeframe, was compared with a control group. Secondary outcomes included questionnaire scores and adult cardiology referral trends.Results:Over 26 months, 53 participants completed an initial Transition Clinic visit; 43% (23/53) underwent a second visit. Median participant age was 18.0 years (interquartile range 16.0, 22.0). The cohort’s “lost to follow-up” rate was 7.3%, which was significantly lower than the control rate (25.9%, p < 0.01). Multivariable regression analyses demonstrated clinic participation as the only factor independently associated with follow-up rates (p = 0.048). Transition readiness was associated with older age (p = 0.01) but not sex, univentricular heart, interventional history, or surgical complexity. One-third of adult participants transferred to adult care.Conclusions:A CHD Transition Clinic intervention can improve follow-up rates in adolescents and young adults. Age is an important factor in transition readiness, and retention of adults in paediatric care appears multi-factorial. We postulate that serial assessments of self-management, focused education, and registry utilisation may improve patient outcomes by reducing lapses in care.
Political Intrusions into the International Health Regulations Treaty and Its Impact on Management of Rapidly Emerging Zoonotic Pandemics: What History Tells Us
Authors: Burkle Frederick M. 
Published: April 2020

AbstractFor a large number of health care providers world-wide, the coronavirus disease 2019 (COVID-19) pandemic is their first experience in population-based care. In past decades, lower population densities, infectious disease outbreaks, epidemics, and pandemics were rare and driven almost exclusively by natural disasters, predatory animals, and war. In the early 1900s, Sir William Osler first advanced the knowledge of zoonotic diseases that are spread from reservoir animals to human animals. Once rare, they now make up 71% or more of new diseases. Globally, zoonotic spread occurs for many reasons. Because the human population has grown in numbers and density, the spread of these diseases accelerated though rapid unsustainable urbanization, biodiversity loss, and climate change. Furthermore, they are exacerbated by an increasing number of vulnerable populations suffering from chronic deficiencies in food, water, and energy. The World Health Organization (WHO) and its International Health Regulation (IHR) Treaty, organized to manage population-based diseases such as Influenza, severe acute respiratory syndrome (SARS), H1N1, Middle East respiratory syndrome (MERS), HIV, and Ebola, have failed to meet population-based expectations. In part, this is due to influence from powerful political donors, which has become most evident in the current COVID-19 pandemic. The global community can no longer tolerate an ineffectual and passive international response system, nor tolerate the self-serving political interference that authoritarian regimes and others have exercised over the WHO. In a highly integrated globalized world, both the WHO with its IHR Treaty have the potential to become one of the most effective mechanisms for crisis response and risk reduction world-wide. Practitioners and health decision-makers must break their silence and advocate for a stronger treaty, a return of the WHO’s singular global authority, and support highly coordinated population-based management. As Osler recognized, his concept of “one medicine, one health” defines what global public health is today.