bluuebunny/crossref_metadata_2025_split huggingface dataset:
HUBUNGAN POLA MAKAN, UMUR DAN PENGETAHUAN DENGAN KEJADIAN HIPERTENSI PADA IBU HAMIL DI WILAYAH KERJA PUSKESMAS KRUENG BARONA JAYA KABUPATEN ACEH BESAR
Authors: Rafsanjani T M , Yasir Yasir , Masyudi Masyudi 
Published: November 2019

Berdasarkan Profil Dinas Kesehatan Aceh Besar Angka kematian ibu tahun 2014 sebanyak 29 orang dengan kasus preeklampsia sebanyak (20,8%), perdarahan sebanyak (20,8%), infeksi/sepsis sebanyak (34,5%), dan penyebab lain sebanyak (24,1%). Dan Berdasarkan survei awal yang dilakukan peneliti di Puskesmas Krueng Barona Jaya Kecamatan Krueng Barona Jaya Kabupaten Aceh Besar, diketahui bahwa pada bulan Januari sampai Mei 2017 didapatkan data jumlah kunjungan ibu hamil sebanyak 367 ibu dan diantaranya memiliki tekanan darah tinggi sebanyak 122 ibu hamil. Hal ini penyebab langsung kematian ibu pada saat persalinan. Penelitian ini bersifat Survei Analitik dengan desain cross sectional, Sampel pada penelitian ini sebanyak 96 responden, dengan analisis data yang digunakan adalah univariat dan bivariat. Tempat penelitian ini dilakukan di Puskesmas Krueng Barona Jaya Kecamatan Krueng Barona Jaya Kabupaten Aceh Besar Tahun 2017. Dari hasil uji statistik chi-square dapat disimpulkan bahwa ada hubungan antara umur dengan hipertensi pada wanita hamil (P-value 0,004 < 0,05) dengan OR 3.722, ada hubungan pengetahuan dengan hipertensi pada wanita hamil (P-value 0,002 < 0,05) dengan OR 4.142 dan terdapat hubungan antara pola makan dengan hipertensi pada wanita hamil (P-value 0,007 < 0,05) dengan OR 3.429 di Puskesmas Krueng Barona Jaya Kecamatan Krueng Barona Jaya Kabupaten Aceh Besar Tahun 2017. Diharapkan kepada Puskesmas dan petugas kesehatan dapat meningkatkan pelayanan dan penyuluhan tentang pentingnya pemeriksaan tekanan dalam masa kehamilan.
Semianalytical Model for Fault Slippage Resulting from Partial Pressurization
Authors: Liu Kui , Dahi Taleghani Arash , Gao Deli 
Published: November 2019

Summary
Casing failure in shale gas wells has seriously impacted production from Weiyuan and Changning fields in Sichuan Province, China. Linearly distributed microseismic data and the corresponding casing shear deformation close to these microseismic signals indicate fault reactivation in these areas during hydraulic-fracturing treatments. Apparently, interaction of hydraulic fractures with nearby faults causes fault slippage, which in some situations has led to well shearing. Hence, we propose a semianalytical model in this paper to estimate the length of slippage along the fault that is caused by pressurization of a fault intercepted by the hydraulic fracture. These calculations have been performed for different configurations of the fault with respect to the hydraulic fracture and principal stresses. Using the semianalytical model provided in this paper, two fault slippage cases are calculated to assess the casing failure in nearby wells. In one case study, the calculated results of the fault slippage are consistent with the scale of casing deformation in that well and a microseismic magnitude caused by fault slippage is calculated that is larger than the detected events. The presented model will provide a tool for a quick estimation of the magnitude of fault slippage upon intersection with a hydraulic fracture, to avoid potential casing failures and obtain a more reliable spacing selection in the wells intersecting faults.
Psychosocial burden, approach versus avoidance coping, social support and quality of life (QOL) in caregivers of persons with dementia in Java, Indonesia: A cross-sectional study
Authors: Hunger Christina , Kuru Sara Sibel , Kristanti Sinta 
Published: November 2019

Abstract
Background: Dementia-caregiving causes severe distress and has a negative impact on caregivers’ health. This study examined the association of family caregivers’ psychosocial burden and quality of life (QOL), using the revised sociocultural model of stress and coping (rSMSC) (Knight & Sayegh, 2010), in an Indonesian sample. Methods: Participants were family caregivers of persons with dementia living in Java, Indonesia. Caregivers completed the Burden Assessment Schedule (BAS), the WHOQOL-Bref, the Brief-COPE and the Multidimensional Scale of Social Support (MSPSS). Mediator analyses were performed to examine the association between psychosocial burden, OQL, social support and approach versus avoidance coping. Results : 45 Indonesian family caregivers (M = 41 years, SD = 12.38; 77.8% female; 64.4% Cohousing) of persons with dementia ((M = 41 years, SD = 12.38) were involved. Caregivers’ psychosocial burden was negatively associated with their QOL. Avoidance coping showed a significant indirect negative effect of psychosocial burden on their QOL in the physical and psychological (partial mediations) and social domain (complete mediation). Approach coping and social support did not reveal significance in the mediation analyses. Conclusion: Interventions for caregivers should integrate psychoeducation and training in the rSMSC, especially focusing on the benefits and harms associated with the different approach and avoidance coping strategies, on cultural values and their impact on the different coping styles, and how these variables are associated to physical, mental and social health. . Keywords: Caregiver, Dementia, Alzheimer, Stress Process Model, Mediation, Indonesia
Determinants Of Low Apgar Score In Newborns Delivered At Lemlem Karl General Hospital, Northern Ethiopia, 2018: A Case Control Study
Authors: Gebremedhin Mussie Mulugeta , Gebremichael Mengistu Welday , Gebremichael Berhane Gebreegizabiher , Reda Mihrete-ab Mehari , Hailu Tesfay Adhena , Gebremeskel Gebrekiros Aregawi , Tilaye Kenean Getaneh , Meikena Henok Kumsa , Yimer Nigus Bililign 
Published: November 2019

Abstract
OBJECTIVE: This study is aimed to investigate determinant factors of low Apgar score in newborns delivered at Lemlem Karl General Hospital, Tigray National Regional State, Ethiopia; 2018.
RESULTS: Socio-demographic characteristics of mothers were not significantly associated . However, antepartum hemorrhage (AOR=3.509; 95%CI 1.526-8.067), pregnancy induced hypertensive disorders (AOR=2.69; 95%CI 1.351-5.357), prolonged second stage of labor (AOR=2.630; 95%CI 1.399-4.944), meconium stained liquor (AOR=6.955; 95%CI 3.721-13.001)) & low birth weight (AOR=4.380; 95%CI 2.216-8.657) were significantly associated with low Apgar score.
Some obstetric factors & one fetal factor were significantly associated with low Apgar score. Therefore, improving labor management of mothers those who are diagnosed with antepartum hemorrhage, pregnancy induced hypertensive disorders, prolonged second stage of labor, and meconium stained liquor is recommended.
KEY WORDS : Determinant, Low Apgar score, Ethiopia.
Antibacterial Activity of Rhamnus prinoides extracts against Staphylococcus aureus and Escherichia coli
Authors: GETA KINDU 
Published: November 2019

Abstract
Background: Infectious diseases caused by bacteria have a large impact on public health. Increasing in resistant microbial infections intensified the search for new, safer, and more efficacious agents to combat serious microbial infections. Plants have played a central part in combating many diseases in human and domestic animal in many local communities, including Africa. Rhamnus prinoides is Ethiopian medicinal plants that have been used traditionally for the treatment of diverse infectious diseases. Therefore, this research was carried out to evaluate antibacterial activity Rhamnus prinoides extracts against pathogenic bacteria. Methods: The antimicrobial activity tests were carried out by the agar well diffusion method. Broth dilution and streak plate methods were used to determine MIC and MBC of extracts respectively. Results: The results revealed that ethanol extracts of fruits showed the highest antibacterial activity against standard strains of S.aureus with mean inhibition zone of 26±0.58, 28.33±1.2 and 33.33±0.9mm at 25, 50 and 100mg/ml respectively. The lowest mean MIC value (1.04±0.26 mg/ml) was recorded with ethanol extract of fruits against standard strains of S. aureus and the lowest mean MBC value (2.08±0.52 mg/ml) was recorded with ethanol extract of fruits against standard strains and clinical isolates of S. aureu. Conclusion: On the basis of the current findings, Rhamnus prinoides could be a good candidate in the search for new antibacterial agents from natural products against bacterial pathogens. Therefore, further studies are needed to study their toxicology and isolate the bio- active components from this plant.
Choice of childbirth place among childbearing age women, western Ethiopia, 2018
Authors: Bekuma Tariku Tesfaye , Firrisa Belaynesh , Girmaye Melese , Kejela Gemechu , Bikila Haile 
Published: November 2019

Abstract
Background : Maternal death is the most extreme consequence of poor maternal health. More than 30 million women in developing regions suffer from serious diseases and disabilities resulted from maternal causes. Access to proper medical attention and hygienic conditions during delivery can reduce the risk of complications and infections that may lead to death of the mother, baby, or both. In Ethiopia, the high maternal mortality rate with delivery by unskilled birth attendants shows low utilization of maternal health services. Objective : This study was aimed to assess choice of childbirth place and its associated factors among women of childbearing age. Method A cross-sectional study design was conducted in Jimma Arjo district, western Ethiopia, from March 20 to April 20, 2018. Multistage sampling technique was used to select 506 participants. Collected data was entered into Epi-Info, checked for its completeness, cleaned and finally exported to SPSS software version 20 for analysis. Bivariate and Multivariable data analysis was used to examine the association between dependent and independent variables. Result : The study investigated that home delivery was found to be 200(39.5%) whereas institutional delivery was 306(60.5%) in the study area. Factors found to be statistically associated with choice of institutional delivery at p<0.05 were; history of obstetric difficulties (AOR=6, 95% CI= [2.08, 17.60]), women educational status (AOR = 4.4, 95% CI= [1.47, 13.42]), husband educational status (AOR=4, 95% CI= [1.43, 11.60]), having 2-3 ANC Visits (AOR=4, 95%CI= [1.95, 8.52]), and accessing vehicle transportation (AOR = 2.8, 95% CI= [1.23, 6.46]). Conclusion: Preference of institutional delivery in this study seems relatively better compared to other studies. It’s shown that attending secondary and more educational level in both mothers’ and their husbands’, history of obstetric difficulties, ANC attendance, and accessing vehicle for transportation have influenced mothers to prefer health institution as childbirth place. Therefore, any programs aimed at increasing choice of institutional delivery should first work on education, ANC follow up and transportation facilities in the study area.
Candidate biomarkers and gene modules investigation for bone tumor samples derived from castration-resistant prostate cancer bone metastasis patients using WGCNA
Authors: Yu Zhongxiang , Zou Hanlin , Wang Huihao , Li Qi , Yu Dong 
Published: November 2019

Abstract
Background About 80-90% of castration-resistant prostate cancer (CRPC) patients would develop bone metastasis, which leads to the disorder of bone metabolism and induces skeletal related events. However, except for the few approved radiotherapeutic and chemotherapy drugs, like radium-223 and denosumab, there is still lack of effective treatment targeting the bone metastatic tumor. It is necessary and significant to explore the mechanisms of bone metastasis and tumorigenesis, especially the differences between the tumor and normal cells in bone after metastatic colonization, which will provide a set of candidate genes for the screening of novel bone targeting agents.Results 4 datasets (GSE32269, GSE101607, GSE29650 and GSE74685) were obtained from the GEO database. 1983 differentially expressed genes (DEGs) were first identified between bone marrow tumor samples and normal marrow samples in GSE32269, followed by the weighted gene co-expression analysis. Most of the top 10 DEGs are found to be related with prostate cancer. 7 co-expression modules were then detected based on the 1469 DEGs shared by the 4 datasets, and 3 of them were found highly preserved among the other three datasets. The top 30 hub genes of the 3 modules were extracted. Among the enriched pathways of preserved modules, Cell adhesion molecules (CAMs) and Leukocyte transendothelial migration might play significant important roles in the tumor development in bone marrow. Literature searches further showed that a set of DEGs and hub genes might also contribute to the development of tumor in bone.Conclusions Together, our findings not only provide outline of expression profile in CRPC bone metastasis, but also screen a set of genes associated with CPRC tumor cell colonization and development of bone tumor, which could be helpful for novel bone targeting agents screening.
Identification of microRNAs and target genes associated with the development of human intervertebral disc degeneration by bioinformatic analysis and verification
Authors: Chang Hongze , Yang Xiaolong , You Kemin , Jiang Mingwei , Cai Feng , Zhang Yan , Liu Liang , Liu Hui , Liu Xiaodong 
Published: November 2019

Abstract
Micro RNAs (miRNAs) are widely recognized to play an essential role via target genes in the development of intervertebral disc degeneration( IDD), but the molecular mechanisms remain unclear. To identify the key microRNAs and potential targets during IDD, the Gene Expression Omnibus datasets (GSE19943, GSE63492, and GSE116726) were downloaded.An R package was used to identify differentially expressed miRNAs (DEMs) and four online tools(TargetScan, miRDB, miRTarBase, and DIANA-TarBase) were performed to predict their target genes. Functional enrichment analysis revealed that DEMs gene targets were highly enriched in cell development, cell differentiation, and the p53 and Wnt signaling pathways. we identified 13 hub genes with node degree≥10 through established a protein-protein interaction (PPI) network. Among them,MAPK8, BMP4, and GSK3B were top 3 highest degree. After constructing the miRNA-target gene-functional analysis network, we found that most hub genes could be regulated by miR-557 and were mainly enriched in cell development, cell differentiation, and Wnt signaling pathway. Further in vitro experiment by qRT-PCR confirmed that miR-577 was significantly downregulated than the control,whereas miR-516-3p was significantly upregulated. Together, the key microRNA and their target genes identified in this study help us understand the underlying pathogenesis mechanisms in the development of IDD, and provide diagnostic biomarkers and new therapeutic strategies for the treatment of IDD.
Prone Position as a Care Practice of the Physical Therapists in Public Neonatal Intensive Care Units in Southern Brazil Prone Position in NICU Southern Brazil
Authors: Martinello Micheli , Johnston Cíntia , Souza Fabíola Isabel Suano , Strufaldi Maria Wany Louzada 
Published: November 2019

Abstract
This study aimed to identify the use of prone position, by physical therapy care, for infants hospitalized in an NICU in the Southern Region of Brazil. This is a cross-sectional study on a public NICU in the Southern Region of Brazil between December 2015 and May 2018, using standardized questionnaires for physical therapists. We included 44 NICU, totaling 104 professionals interviewed, the mean age of the interviewed was 33.5 years (SD: 7.12) and the mean experience time in the area was 7.7 years (SD: 6.9), and 85.2% reported to have specialization. According to 68.3% of the respondents, there is a protocol for the change of position in the Unit, but the prone position is not indicated in most NICUs (59.6%). Most of the respondents (65.4%) answered affirmatively, but 73.1% reported limitations in their incorporation into the Services, often related to aspects external to the newborn (lack of exclusive or full-time professionals in the NICU (75%) and a reduced number of professionals (33.6%)). The prone position is generally not indicated in the hospital (57.7%). Conclusion: Aspects related to professional qualification and length of experience in neonatology may have contributed to the limited alternation of position during the hospitalization of the newborn and less emphasis of the prone position in the guidance to the family/caregivers. Also, a lack of exclusive or comprehensive physical therapists and the disproportion between demand and number of professionals has been observed.
Comparison and optimization of the performance of natural-based non-conventional coagulants in a water treatment plant
Authors: Kaji Atefeh , Taheriyoun Masoud , Taebi Amir , Nazari-Sharabian Mohammad 
Published: November 2019

Abstract
This study aims to assess the efficiency of two natural-based coagulants, namely calcium lactate and tannic acid, and compare them with conventional coagulants, including polyaluminium chloride (PACl) and ferric chloride. Jar test experiments were performed on the raw inlet water of the Isfahan water treatment plant (IWTP) in Iran. Response surface methodology was implemented to design and optimize the experiments. The factors considered in the design were coagulant dose, pH, initial turbidity, and temperature. Results showed the acceptable efficiency of natural coagulants in turbidity reduction, so that they meet the potable standard levels. The final water turbidity in the optimum condition for calcium lactate, tannic acid, PACl, and ferric chloride were 0.58, 0.63, 0.56, and 0.76 NTU, respectively. The comparison between the performances of the coagulants showed no significant difference in turbidity removal. However, the sludge volume produced as well as the impact on pH alteration after coagulation–flocculation were lower when using natural coagulants than with conventional coagulants. Also, the residual aluminum for PACl measured was higher than the desired limit according to Iran's drinking water standard. Finally, the simple additive weighting method was used to rank the four coagulants based on the selected criteria. The results showed that the natural coagulants could be preferable to the conventional coagulants if the concerns regarding disinfection by-product formation due to their residual organics were resolved. Since this issue was fixed in the IWTP due to the ozonation process, calcium lactate was proposed as an efficient alternative to PACl.
Fuzzy Corner Metric Based Brain Tumor Segmentation And Grade Classification
Authors: Sundaram Kalyana , Gnanavadivel J. 
Published: November 2019

Background:
The main idea this work is to reduce the physician time by assessing with computer aided tumor detection Human investigation is the routine technique for brain MRI tumor detection and tumors classification. Interpretation of images is based on organized and explicit classification of brain MRI and also various techniques have been proposed.

Methods:
The proposed system segments the Brain MR images with the help of fuzzy corner points and the segmented tumor area is subjected for grade classification. Support vector machine classifier is implemented for the grade classification.

Result & Conclusion:
The proposed system is addressing a simple and robust technique for the tumor diagnosis and also the performance is 89.5% which is comparatively high when compared to the traditional classification method.
Spirulina maxima L-asparaginase: Immobilization, Antiviral and Antiproliferation Activities
Authors: Abd El-Baky Hanaa H. , El-Baroty Gamal S. 
Published: November 2019

Background:
L-asparaginase (L-AsnA) enzyme has gained significant attention in the
food, biocatalysts and pharmaceutics industry. It (L-AsnA) has been widely used in food processing
industries as a promising acrylamide mitigating agent and as a therapeutic agent in the treatment
of certain human cancers.

Objective:
Based on US Patent (4,433,054; 1984), L-asparaginase (L-AsnA) enzyme is immobilized
by admixing the active enzyme on the polysaccharide to be in a gel form. The storage stability
of immobilized L-AsnA enzyme and its anti-proliferation and antiviral activity were determined.

Methods:
In the present study, S. maxima was cultured at large scales (300 liter) for the production
of enough extracellular L-asparaginase (L-AsnA) using modified (high N concentration) Zarrouk
medium as we reported in a previous study. L-AsnA was immobilized on natural polymers,
as agar cake beads, agarose pieces and gelatin blocks, in order to evaluate the efficiency of physical
entrapment techniques. Anti-proliferation properties of L-AsnA against lung carcinoma A549,
hepatocellular carcinoma Hep-G2 and prostate carcinoma PC3 human cancer cell lines were assessed
by the MTT cell viability method. In addition, the antiviral activity against Coxsackie B3
(CSB3) Virus was assessed.

Results:
The highest L-AsnA immobilized activity and immobilization yield were achieved with
agar cakes bead. The purified S. maxima L-AsnA showed good antiviral activity against Coxsackie
B3 (CSB3) Virus in a dose-dependent manner with an IC50 value 17.03 μg/ml. The antiviral
mode of action is presumably due to their capability of inhibiting attachment, blocking the adsorption
and penetration event of the viral replication cycle with 89.24%, 72.78% and 72.78%, respectively.
Also, S. maxima L-AsnA showed anti-proliferation effect against lung carcinoma A549,
hepatocellular carcinoma Hep-G2 and prostate carcinoma PC3 human cancer cell lines, with an
IC50 of 22.54, 24.65 and 56.61 μg/ml, respectively.

Conclusion:
It is interesting to favor L-asparaginase of S. maxima which showed antiviral activity
and anti-proliferation effect against different types of human cell lines. Thus, S. maxima microalgae
might be a good source for L-AsnA enzymes and can be immobilized on natural polymers.
Import Need for Wound Care and Burn Dressings in India: A Bioeconomic Challenge
Authors: Yadav Vibhu , Mittal Amit , Bansal Parikshit , Singh Sachin K. 
Published: November 2019

Objective:
To present an overview of import need for wound care and burn dressings in
India. This article provides a complete analysis of the import-export value of wound care and burn
dressings in India. It helps in preparing growth strategies, knowledge about leading players, recent
developments, business strategies, and manufacturing status of the wound care and burn dressings
in India.

Methodology:
A trend analysis of import-export was carried out for wound and burn dressings in India.
Raw data of the years (2008-2017) were collected from various market research analysis sites
and import need was identified.

Results and Discussion:
The detailed analysis reveals that India is a growing market for wound
and burn dressings and spends a lot of the exchequer on importing the subject commodity. Wound
dressing export is averaged to the same from 2013 to 2017. India saw a rise in wound dressing export
after 2012. India saw a rise of wound dressing import over the past 10 years. It averaged
502.6 million from 2008 to 2017 and it reached its all-time high of 765 million in 2016. The import
value was found quite high as compared to export.

Conclusion:
The report of import and export analysis very clearly highlights that there is a strong
demand for dressings in the country and due to lack of own manufacturers of such dressing in India,
these are imported. Since these products are expensive, there is a large outflow of Indian currency
due to imports. It is imperative that such products get government attention and should be
manufactured within the country.