bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Advances in Experimental Techniques for Flow and Mass Transfer Analyses in Thermal Separation Systems
Authors: Hampel Uwe , Schubert Markus , Döß Alexander , Sohr Johanna , Vishwakarma Vineet , Repke Jens‐Uwe , Gerke Sören J. , Leuner Hannes , Rädle Matthias , Kapoustina Viktoria , Schmitt Lucas , Grünewald Marcus , Brinkmann Jost H. , Plate Dominik , Kenig Eugeny Y. , Lutters Nicole , Bolenz Lukas , Buckmann Felix , Toye Dominique , Arlt Wolfgang , Linder Thomas , Hoffmann Rainer , Klein Harald , Rehfeldt Sebastian , Winkler Thomas , Bart Hans‐Jörg , Wirz Dominic , Schulz Jonas , Scholl Stephan , Augustin Wolfgang , Jasch Katharina , Schlüter Florian , Schwerdtfeger Natalie , Jahnke Stefan , Jupke Andreas , Kabatnik Christoph , Braeuer Andreas Siegfried , D'Auria Mirko , Runowski Thomas , Casal Maria Francisco , Becker Karsten , David Anna‐Lena , Górak Andrzej , Skiborowski Mirko , Groß Kai , Qammar Hina 
Published: June 2020

AbstractModelling flow and mass transfer of thermal separation equipment constitutes one of the most challenging tasks in fluids process engineering. The difficulty of this task comes from the multiscale multiphase flow phenomena in rather complex geometries. Both analysis of flow and mass transfer on different scales as well as validation of models and simulation results require advanced experimental and measurement techniques. As a follow‐up to intensive discussions during the 2019 Tutzing Symposium “Separation Units 4.0” a wide set of available modern experimental technologies is presented.
SA Sketch: A self‐adaption sketch framework for high‐speed network
Authors: Zhu Haiting , Zhang Yuan , Zhang Lu , He Gaofeng , Liu Linfeng , Liu Ning 
Published: June 2020

SummarySketch is a compact data structure used to summarize data streams. It is widely used in the measurement of network traffic, and its accuracy is higher than traditional methods. Currently, there are some typical sketches: Count‐Min Sketch, CU Sketch, and Count Sketch. According to the characteristics of network traffic, we propose a new sketch framework called Self‐Adaption Sketch, which is combined Sketch with Bloom Filter. In the framework, the sketch is created dynamically and the memory space is adjusted timely according to the network traffic by using the concept carrying. Our experiment results showed that the space utilization and accuracy are significantly improved while the throughput of self‐adaption sketch is maintained at a relatively good level.
Lymphocyte Subset Counts in COVID‐19 Patients: A Meta‐Analysis
Authors: Huang Wei , Berube Julie , McNamara Michelle , Saksena Suraj , Hartman Marsha , Arshad Tariq , Bornheimer Scott J. , O'Gorman Maurice 
Published: June 2020

AbstractA reduced peripheral blood absolute lymphocyte count with an elevated neutrophil count has been a consistent observation in hospitalized coronavirus disease 2019 (COVID‐19) patients. In this brief meta‐analysis, the reduction of lymphocyte subset counts in COVID‐19 patients was investigated across 20 peer‐reviewed studies meeting criteria for reporting lymphocyte subset counts and COVID‐19 disease severity. CD4+ T cell, CD8+ T cell, B cell, NK cell, and total lymphocyte cell counts all showed statistically significant reduction in patients with severe/critical COVID‐19 disease compared to mild/moderate disease. T‐cell subsets showed the largest standardized magnitude of change. In some studies, multivariate analysis has shown that CD4 and/or CD8 T‐cells counts are independently predictive of patient outcomes. © 2020 International Society for Advancement of Cytometry
A high‐throughput method to quantify feeding rates in aquatic organisms: A case study with Daphnia
Authors: Hite Jessica L. , Pfenning‐Butterworth Alaina C. , Vetter Rachel E. , Cressler Clayton E. 
Published: June 2020

Abstract

Food ingestion is one of the most basic features of all organisms. However, obtaining precise—and high‐throughput—estimates of feeding rates remains challenging, particularly for small, aquatic herbivores such as zooplankton, snails, and tadpoles. These animals typically consume low volumes of food that are time‐consuming to accurately measure.

We extend a standard high‐throughput fluorometry technique, which uses a microplate reader and 96‐well plates, as a practical tool for studies in ecology, evolution, and disease biology. We outline technical and methodological details to optimize quantification of individual feeding rates, improve accuracy, and minimize sampling error.

This high‐throughput assay offers several advantages over previous methods, including i) substantially reduced time allotments per sample to facilitate larger, more efficient experiments; ii) technical replicates; and iii) conversion of in vivo measurements to units (mL‐1 hr‐1 ind‐1) which enables broad‐scale comparisons across an array of taxa and studies.

To evaluate the accuracy and feasibility of our approach, we use the zooplankton, Daphnia dentifera, as a case study. Our results indicate that this procedure accurately quantifies feeding rates and highlights differences among seven genotypes.

The method detailed here has broad applicability to a diverse array of aquatic taxa, their resources, environmental contaminants (e.g., plastics), and infectious agents. We discuss simple extensions to quantify epidemiologically relevant traits, such as pathogen exposure and transmission rates, for infectious agents with oral or trophic transmission.
Tolvaptan vs. furosemide‐based diuretic regimens in patients hospitalized for heart failure with hyponatremia (AQUA‐AHF)
Authors: Ng Tien M.H. , Grazette Luanda P. , Fong Michael W. , Yoon Andrew J. , Lou Mimi , Kuo Allen , Upadhyay Rani Y. , Han Emily E. , Mehra Anilkumar , Elkayam Uri 
Published: June 2020

AbstractAimsHyponatremia is associated with poorer outcomes and diuretic response in patients hospitalized for heart failure. This study compared a tolvaptan‐based vs. furosemide‐based diuretic regimen on short‐term clinical responses in hyponatremic acute heart failure.Methods and resultsProspective, randomized, open‐label, parallel‐group, single‐centre study comparing oral tolvaptan vs. continuous infusion furosemide. Thirty‐three subjects requiring hospitalization for acute congestive heart failure, and a serum sodium < 135 mmol/L, were randomized to tolvaptan 30 mg orally daily or furosemide 5 mg/h intravenously for initial 24 h, after which treatments could be escalated. Median daily dose throughout was tolvaptan 30 mg and furosemide 120 mg, with four subjects in each group requiring dose escalation. Urine output and net fluid balance were not different between groups at 24 h or subsequent time points up to 96 h. Changes in estimated glomerular filtration rate were comparable. Cystatin C improved at 24 h with tolvaptan compared with furosemide (−6.4 ± 11.8 vs. 4.1 ± 17.2% change, P = 0.036), but the effect was transient. No significant between group differences were seen for NT‐proBNP, plasma renin activity, or urinary neutrophil gelatinase‐associated lipocalin:Cr. Serum sodium, as well as copeptin levels, increased with tolvaptan compared with furosemide.ConclusionsOral tolvaptan was associated with similar, but not superior, diuresis compared with intravenous furosemide for acute heart failure with concomitant hyponatremia.
BotDetector: An extreme learning machine‐based Internet of Things botnet detection model
Authors: Dong Xudong , Dong Chen , Chen Zhenyi , Cheng Ye , Chen Bo 
Published: June 2020

AbstractThe development of artificial intelligence has brought new methods for botnet detection. For better performance, deep learning (DL) is more and more widely employed to botnet detecting. The existing DL‐based botnet detection methods require lots of computing resources and running time. While in the real Internet of Things (IoT) environment, real‐time and low computing consumption are much needed. Therefore, the DL‐based methods seem to be powerless in real‐time IoT scenarios. For these reasons, this article proposes a botnet detection model based on extreme learning machine, named BotDetector, which can directly obtain network stream files and quickly learn without data processing to extract botnet traffic characteristics. Experiments show that BotDetector has a good performance, which can identify botnets accurately with great reduction the time consumption and resource consumption. Furthermore, BotDetector has strong applicability in real IoT scenes.
Nonpeghylated liposomal doxorubicin combination regimen (R‐COMP) for the treatment of lymphoma patients with advanced age or cardiac comorbidity
Authors: Rigacci Luigi , Annibali Ombretta , Kovalchuk Sofya , Bonifacio Elisabetta , Pregnolato Francesca , Angrilli Francesco , Vitolo Umberto , Pozzi Samantha , Broggi Serena , Luminari Stefano , Merli Francesco , Spina Michele , Bolis Silvia , Margiotta‐Casaluci Gloria , Scalzulli Rosario , Cox Christina , Mamusa Angela Maria , Santoro Armando , Zinzani Pier Luigi , Ferrari Samantha , Gini Guido , Vigliotti Maria Luigia , Mulè Antonino , Flenghi Leonardo ,   Fondazione Italiana Linfomi (FIL)
Published: June 2020

AbstractDoxorubicin is the most effective single agent in the treatment of non‐Hodgkin's lymphoma (NHL). Its use is limited because of the cardiac toxicity primarily in elderly patients (pts) and in pts with history of cardiac disease. Liposomal doxorubicin has been proven to reduce cardiotoxicity. The aim of this retrospective study was the use of nonpeghylated liposomal doxorubicin (NPLD) in term of efficacy, response rate and incidence of cardiac events. We retrospectively collected the experience of 33 Hematological Italian Centers in using NPLD. Nine hundred and forty‐six consecutive pts treated with R‐COMP (doxorubicin was substituted with NPLD, Myocet) were collected. Median age was 74 years, the reasons for use of NPLD were: age (466 pts), cardiac disease (298 pts), uncontrolled hypertension (126 pts), other reasons (56 pts). According to clinicians' evaluation, 49.9% of pts would not have used standard doxorubicin for different situations (age, cardiomyopathy, previous use of doxorubicin, and uncontrolled hypertension). Overall 687 pts (72.6%) obtained a complete remission (CR). About 5% (n = 51) of subjects developed major cardiotoxic events including heart failure (N = 31), ischemic heart disease (N = 16), acute heart attack (N = 3), and acute pulmonary oedema (N = 1). After a median follow‐up of 32 months, 651 pts were alive and the overall survival (OS) was 72%. After a median observation period of 23 months disease free survival (DFS) was 58%. Either in univariate or in multivariate analysis OS and DFS were not significantly affected by age or cardiac disease. Our findings strongly support that including R‐COMP is effective and safe when the population is at high risk of cardiac events and negatively selected. Moreover, the use of this NPLD permitted that about half of our population had the opportunity to receive the best available treatment.
Making the right friends: A social network perspective on newcomer socialization in teams
Authors: Yuan Zhenyu , Li Ning , Mai Yiyuan , Ye Zhuxin , Yu Jia (Joya) 
Published: June 2020

AbstractDespite the prevalence of work teams in organizations, how newcomers become integrated into teams remains an understudied area. Drawing on research related to indirect social resources, in this paper we employ a social network perspective to examine how close teammates' friendship centrality can facilitate newcomers' adjustment by fostering the newcomers' own social capital in teams and promoting their subsequent task performance. Furthermore, our model incorporates institutionalized socialization tactics and political skill as two contingencies that can further strengthen the positive effects of indirect social resources on newcomers' adjustment. In a time‐lagged study using multiple sources of data, we found good support for our hypotheses. Specifically, close teammates' friendship centrality was positively related to newcomers' task performance through the mediating effect of newcomers' own friendship centrality in teams. The two moderators further strengthened this indirect effect. Overall, this study highlights the importance of “making the right friends” to facilitate newcomer adjustment into teams.
Prevalence of high‐risk human papillomavirus after HPV‐vaccination in Denmark
Authors: Lynge Elsebeth , Thamsborg Lise , Larsen Lise Grupe , Christensen Jette , Johansen Tonje , Hariri Jalil , Christiansen Sanne , Rygaard Carsten , Andersen Berit 
Published: June 2020

AbstractVaccination against human papillomavirus (HPV) has been introduced as a public health initiative in many countries, including Denmark since October 2008. It is important to monitor postimplementation effectiveness of HPV‐vaccination at the population‐level. We studied HPV‐prevalence after first invitation to screening at age 23 years in women offered the quadrivalent HPV‐vaccine at the age of 14 years. Randomly selected screening samples from women born in 1994 in four out of five Danish regions were subjected to analysis for HPV in addition to routine cytology. Cobas4800 was used in all participating pathology departments. Data from a Danish prevaccination cross‐sectional study using Hybrid Capture 2, and a Danish split‐sample study using Cobas4800 were used for comparison. In the period from February 2017 to April 2019, 6233 screening samples from women born in 1994 were selected for HPV‐analysis; 27 samples had no HPV‐test and 3 samples had no HPV‐diagnosis, leaving 6203 samples with an HPV‐diagnosis. Prevalence of any high‐risk (HR) HPV was 35%; only 0.9% were positive for vaccine HPV types 16/18 while the remaining 34% were positive for other HR HPV. When comparing with prevaccination prevalence data, HPV‐16/18 decreased by 95%; RR = 0.05 (95% CI 0.04‐0.06), while other HR HPV remained fairly constant; RR = 0.88 (95% CI 0.82‐0.94) and RR = 0.95 (95% CI 0.88‐1.03), respectively. One‐third of women vaccinated as girls with the quadrivalent HPV‐vaccine were HR HPV‐positive at time of first invitation to screening. Vaccine HPV‐types 16 and 18 were almost eliminated, while the prevalence of nonvaccine HR HPV‐types remained constant.
VacA genotypes and cagA‐EPIYA‐C motifs of Helicobacter pylori and gastric histopathological lesions
Authors: El Khadir Mounia , Boukhris Alaoui Samia , Benajah Dafr‐Allah , Ibrahimi Sidi Adil , Chbani Laila , El Abkari Mohamed , Bennani Bahia 
Published: June 2020

AbstractHelicobacter pylori infection induces inflammation of the gastric mucosa, which may progress to precancerous lesions and gastric cancer. The gastric histo‐pathological damages may be associated with some virulence genes of the bacterium, notably vacA and cagA genes. To establish correlations between these genes and the lesions, biopsies from 1303 adults consenting patients that were previously analyzed by PCR to characterize vacA‐s vacA‐m, vacA‐i regions and cagA 3′ region polymorphism, were used. The highest average age was obtained in patients with intestinal metaplasia (53.65 ± 15.26 years) and gastric cancer (53.60 ± 14.32 years). Thus, these lesions are more frequent in elderly and male subjects. Tobacco smoking was significantly associated with neutrophilic activity (P = .02). No significant association was obtained between patients with chronic inflammation and vacA and cagA H. pylori genotypes. However, a significant association has been obtained between this lesion and cagA+ in aged patients (P = .02), while intestinal metaplasia was significantly associated with vacAi1 and vacAm1 separately (P < .01 and .01). Also, a significant association was obtained between intestinal metaplasia and strains with one EPIYA‐C motif in young patients (P = .001). Interestingly, a significant association was obtained between gastric cancer and cagA+, vacAi1, vacAm1 H. pylori genotypes and also with two EPIYA‐C motifs independently of age groups (all P < .05). The results of our study show that H. pylori vacAi1 could be more potent than the other H. pylori virulent factors for predicting the precancerous gastric lesions, confirming that this gene may be helpful to identify patients at high risk for gastric cancer.
Successful pembrolizumab treatment in a patient with metastatic urothelial carcinoma and underlying overlap syndrome involving systemic sclerosis and systemic lupus erythematosus
Authors: Kurokawa Masayuki , Naito Sei , Ito Suguru , Takai Satoshi , Kawamura Yuko , Kaneko Hisashi , Kakizaki Hiroshi , Tsuchiya Norihiko 
Published: June 2020

IntroductionThe safety and efficacy of pembrolizumab administration in patients with urothelial carcinoma and underlying autoimmune disease (including overlap syndrome) is unknown.Case presentationWe present the case of a 67‐year‐old woman with cT3N2M0 metastatic renal pelvic cancer who had been treated with prednisolone for overlap syndrome involving systemic sclerosis and systemic lupus erythematosus for 20 years. She had a remarkable response to pembrolizumab as a third‐line systemic therapy, wherein the tumor reduced in size and all regional lymph node and pulmonary metastases disappeared. She did not develop any immune‐related adverse events or autoimmune disease flare‐ups during the treatment.ConclusionThis case report suggests that pembrolizumab could be beneficial to patients with urothelial carcinoma and underlying well‐controlled overlap syndrome.
Medication‐related 30‐day rehospitalizations in palliative care patients
Authors: Pruskowski Jennifer A. , Ruby Christine M. , Berenbrok Lucas A. , Seybert Amy L. , Handler Steven M. 
Published: June 2020

AbstractPurposePrior studies suggest that inpatient palliative care services can reduce rehospitalizations. However, medications commonly prescribed by palliative care providers (eg, opioids, benzodiazepines, and antipsychotics) have been independently associated with rehospitalizations. Little is known regarding the role of adverse drug reaction (ADR)‐related rehospitalizations within the palliative care population.ObjectiveTo determine the prevalence and explore predictors of ADR‐related 30‐day rehospitalizations in an inpatient palliative care population.MethodsA retrospective cohort study that included 284 palliative care patients who were readmitted within 30‐days of discharge from two academic hospitals in Western Pennsylvania. All unplanned rehospitalizations were assessed for medication causality via the Naranjo algorithm by at least two independent reviewers.ResultsThe mean (SD) age of the cohort was 61 (16) years and included 45% (n = 127) female and 81% Caucasians (n = 229). Of the 254 unplanned rehospitalizations, 11 (4%) were classified as doubtful ADRs, 224 (88%) were classified as possible ADRs, and 19 (7%) were defined as probable or definite ADR‐related. Tacrolimus was associated with three probable and one definite ADR‐related rehospitalization. Oncologic agents (eg, venetoclax, nivolumab, vincristine, and decitabine, carfilzomib; n = 5), anticoagulants (eg, rivaroxaban, apixaban, and warfarin; n = 4), antimicrobials (eg, cephalexin and vancomycin; n = 2), potassium chloride (n = 2), lorazepam (n = 1), and nicotine replacement (n = 1) were all associated with probable ADRs. Only the number of medication changes during the index admissions was observed as a statistically significant predictor of rehospitalizations in this population (P = .043).ConclusionsPalliative care patients often suffer from potential ADR‐related rehospitalizations and the number of medication changes during the index hospital admissions is associated with future potential ADRs. Clinical pharmacists should consider these findings when developing initiatives to reduce rehospitalizations in the inpatient palliative care patient population.
Partnerships between universities and nonprofit transition coaching organizations to increase student success
Authors: Farruggia Susan P. , Solomon Bonnie , Back Lindsey , Coupet Jason 
Published: June 2020

AbstractAimsThis study aims to understand the motivations and benefits for universities and nonprofit college access and success organizations to develop formal partnerships.MethodsParticipants in this study were staff from a major urban research university (n = 22) and four nonprofit organizations (n = 17) that promote college access and success among underrepresented, low‐income, and first‐generation college students. Participants engaged in an audio‐recorded interview that was transcribed and analyzed using thematic analysis.ResultsData suggested that staff from the universities and nonprofit organizations were both holistic in their understanding of college student success. In addition, they were both motivated to form partnerships in an effort to reduce barriers to success, although they, at times, identified different barriers that they wanted the partnership to address. Both university and nonprofit staff saw increased effectiveness of their practice as a result of partnering and university staff gained a better understanding of the greater nonprofit college access and success community.ConclusionGiven the intense support that nonprofit organizations are able to provide with their level of funding, partnerships with universities can increase the success of underrepresented, low‐income, and first‐generation college students.
Retracted: Paeoniflorin promotes angiogenesis and tissue regeneration in a full‐thickness cutaneous wound model through the PI3K/AKT pathway
Authors: Dong Xiaoyu , He Zili , Xiang Guangheng , Cai Leyi , Xu Zhenjiang , Mao Cong , Feng Yongzeng 
Published: June 2020

AbstractThe treatment of wounds remains a clinical challenge because of poor angiogenesis under the wound bed, and increasingly, the patients' need for functional and aesthetically pleasing scars. For the wound healing process, new blood vessels which can deliver nutrients and oxygen to the wound area are necessary. In this study, we investigated the pro‐angiogenesis ability and mechanism in wound healing of paeoniflorin (PF), which is a traditional Chinese medicine. In our in vitro results, the ability for proliferation, migration and in vitro angiogenesis in human umbilical vein endothelial cells was promoted by coculturing with PF (1.25–5 μM). Meanwhile, molecular docking studies revealed that PF has excellent binding abilities to phosphatidylinositol‐3‐kinase (PI3K) and protein kinase B (AKT), and consistent with our western blot results, that PF suppressed PI3K and AKT phosphorylation. Furthermore, to investigate the healing effect of PF in vivo, we constructed a full‐thickness cutaneous wound model in rats. PF stimulated the cellular proliferation status, collagen matrix deposition and remodeling processes in vitro and new blood vessel formation at the wound bed resulting in efficient wound healing after intragastric administration of 10 mg·kg−1·day−1 in vivo. Overall, PF performed the pro‐angiogenetic effect in vitro and accelerating wound healing in vivo. In summary, the capacity for angiogenesis in endothelial cells could be enhanced by PF treatment via the PI3K/AKT pathway in vitro and could accelerate the wound healing process in vivo through collagen deposition and angiogenesis in regenerated tissue. This study provides evidence that application of PF represents a novel therapeutic approach for the treatment of cutaneous wounds.