bluuebunny/crossref_metadata_2025_split huggingface dataset:
Befragung von Medizinstudierenden zu der ärztlichen Aufklärung und zu den ärztlichen Informationspflichten sowie zur medizinrechtlichen Ausbildung im Studium
Authors: Kern N. , Holz F. , Verhoff M. A. , Parzeller M. 
Published: September 2020

Zusammenfassung
Hintergrund
Mit dem Masterplan 2020 und den an mehreren Universitäten eingeführten Modellstudiengängen befindet sich das Medizinstudium aktuell im Umbruch. Sowohl im Regel- als auch im Modellstudiengang werden medizinrechtliche Aspekte überwiegend im Rahmen rechtsmedizinischer Ausbildungsabschnitte unterrichtet. Allerdings werden Studierende bereits während Famulaturen oder im praktischen Jahr mit juristischen Fragen konfrontiert.
Ziel der Studie war es herauszufinden, ob und in welchem Umfang Studierende der Humanmedizin insbesondere zur ärztlichen Aufklärung und zu den ärztlichen Informationspflichten bis zum Beginn des 4. bzw. 5. klinischen Semesters auf medizinrechtliche Aspekte vorbereitet wurden, und ob Verbesserungen bei der medizinrechtlichen Lehre gewünscht werden.

Material und Methoden
Zwischen den Sommersemestern 2017 und 2019 wurde zu Beginn des Kurses für Rechtsmedizin eine quantitative, standardisierte Umfrage mit insgesamt 373 Studierenden durchgeführt.

Ergebnisse
Wenngleich 98,8 % der Studierenden angaben, Aufklärungsgespräche bereits (mehrfach) praktisch ausgeübt zu haben, bestanden deutliche Defizite in Bezug auf die juristischen Anforderungen an das ärztliche Aufklärungsgespräch und dessen Delegation. So gaben lediglich 5,1 % der Studierenden an, die rechtlichen Grundlagen der ärztlichen Aufklärung sowie die entsprechende Norm aus dem Zivilrecht zu kennen. Über 80 % der Befragten fühlten sich unzureichend auf die rechtlichen Aspekte des praktischen Jahres vorbereitet. Über 90 % der Studierenden wünschten sich eine bessere medizinrechtliche Ausbildung.

Diskussion
Eine fächerübergreifende Etablierung sowie eine über das gesamte Studium verteilte Lehre von Medizinrecht könnte die Vorbereitung auf das praktische Jahr verbessern und das Verständnis für die rechtlichen Anforderungen an die ärztliche Berufstätigkeit fördern. Nach dem derzeitigen Stand der Umsetzung des Masterplans 2020 soll das Medizinrecht in der Learning Opportunities, Objectives and Outcomes Platform (LOOOP) als verbindlicher Ausbildungs- und Lehrinhalt etabliert werden.
Energy of sections of the Deligne–Hitchin twistor space
Authors: Beck Florian , Heller Sebastian , Röser Markus 
Published: September 2020

AbstractWe study a natural functional on the space of holomorphic sections of the Deligne–Hitchin moduli space of a compact Riemann surface, generalizing the energy of equivariant harmonic maps corresponding to twistor lines. We show that the energy is the residue of the pull-back along the section of a natural meromorphic connection on the hyperholomorphic line bundle recently constructed by Hitchin. As a byproduct, we show the existence of a hyper-Kähler potentials for new components of real holomorphic sections of twistor spaces of hyper-Kähler manifolds with rotating $$S^1$$

S
1

-action. Additionally, we prove that for a certain class of real holomorphic sections of the Deligne–Hitchin moduli space, the energy functional is basically given by the Willmore energy of corresponding equivariant conformal map to the 3-sphere. As an application we use the functional to distinguish new components of real holomorphic sections of the Deligne–Hitchin moduli space from the space of twistor lines.
The Moss Biomonitoring Method and Neutron Activation Analysis in Assessing Pollution by Trace Elements in Selected Polish National Parks
Authors: Kosior Grzegorz , Frontasyeva Marina , Ziembik Zbigniew , Zincovscaia Inga , Dołhańczuk-Śródka Agnieszka , Godzik Barbara 
Published: September 2020

AbstractThe concentrations of trace elements in feather mossPleurozium schreberi(Brid.) Mitt. were used to indicate the relative levels of air pollution by trace elements in Polish national parks.Pleurozium schreberiwas collected from nine national parks. The highest concentrations were recorded in the moss samples from the southern and most industrialised part of the country; the lowest from northern and north-eastern Poland. A comparison of data obtained from Polish national parks in the 1970s and 1990s showed a significant decrease in the concentrations of heavy metals. In the linear covariability estimation, thetquantile approach was used for multi-element comparison. A number of positive covariabilities were observed. This is a result of anthropogenic activity and the geochemical characteristics of the local environment, including crust composition to which soil composition is related. The statistical approach oftquantile to study common relationships between element concentrations can be used in the interpretation of biomonitoring research results in similar studies.
Immune checkpoint-related serum proteins and genetic variants predict outcomes of localized prostate cancer, a cohort study
Authors: Wang Qinchuan , Ye Yuanqing , Yu Hao , Lin Shu-Hong , Tu Huakang , Liang Dong , Chang David W. , Huang Maosheng , Wu Xifeng 
Published: September 2020

Abstract
Background
The clinical predictors and biological mechanisms for localized prostate cancer (PCa) outcomes remain mostly unknown. We aim to evaluate the role of serum immune-checkpoint-related (ICK) proteins and genetic variations in predicting outcomes of localized PCa.

Methods
We profiled the serum levels of 14 ICK-related proteins (BTLA, GITR, HVEM, IDO, LAG-3, PD-1, PD-L1, PD-L2, Tim-3, CD28, CD80, 4-1BB, CD27, and CTLA-4) in 190 patients with localized PCa. The genotypes of 97 single nucleotide polymorphisms (SNPs) from 19 ICK-related genes were analyzed in an extended population (N = 1762). Meta-data from ArrayExpress and TCGA was employed to validate and to probe functional data. Patients were enrolled and tumor aggressiveness, biochemical recurrence (BCR), and progression information were obtained. Statistical analyses were performed analyzing associations between serum biomarkers, genotypes, mRNA and outcomes.

Results
We showed that serum (s)BTLA and sTIM3 levels were associated with PCa aggressiveness (P < 0.05). sCD28, sCD80, sCTLA4, sGITR, sHVEM and sIDO correlated with both BCR and progression risks (all P < 0.05). We further identified ICK variants were significantly associated with aggressiveness, BCR and progression. Among them, 4 SNPs located in CD80 (rs7628626, rs12695388, rs491407, rs6804441) were not only associated with BCR and progression risk, but also correlated with sCD80 level (P < 0.01). rs491407 was further validated in an independent cohort. The CD80 mRNA expression was associated with BCR (HR, 1.85, 95% CI 1.06–3.22, P = 0.03) in meta-analysis of validation cohorts.

Conclusion
We highlight the prognostic value of serum ICK-related proteins for predicting aggressiveness, BCR and progression of PCa. The genetic variations and mRNA expression in CD80 could be predictors and potential targets of localized PCa.
Prospectively Randomized Controlled Trial on Damage Control Surgery for Perforated Diverticulitis with Generalized Peritonitis
Authors: Kafka‐Ritsch Reinhold , Zitt Matthias , Perathoner Alexander , Gasser Elisabeth , Kaufman Claudia , Czipin Sasha , Aigner Felix , Öfner Dietmar 
Published: September 2020

AbstractIntroductionDamage control surgery (DCS) with abdominal negative pressure therapy and delayed anastomosis creation in patients with perforated diverticulitis and generalized peritonitis was established at our Institution in 2006 and has been published. The concept was adopted in other hospitals and published as a case series. This is the first prospectively controlled randomized study comparing DCS and conventional treatment (Group C) in this setting.MethodsAll consecutive patients from 2013 to 2018 with indication for surgery were screened and randomized to Group DCS or Group C. The primary outcome was the rate of reconstructed bowel at discharge and at 6 month. Informed consent was obtained. The trial was approved by the local ethics committee and registered at CinicalTrials.gov: NCT04034407.ResultsA total of 56 patients were screened; 41 patients gave informed consent to participate and ultimately 21 patients (9 female) with intraoperatively confirmed Hinchey III (n = 14, 67%) or IV (n = 7, 33%), and a median (range) age of 66 (42–92), Mannheim Peritonitis Index of 25 (12–37) and Charlson Comorbidity Index of 3 (0–10) were intraoperatively randomized and treated as Group DCS (n = 13) or Group C (n = 8). Per protocol analysis: A primary anastomosis without ileostomy (PA) was performed in 92% (11/12) patients in Group DCS at the second‐look operation, one patient died before second look, and one underwent a Hartmann procedure (HP). In Group C 63% (5/8) patients received a PA and 38% (3/8) patients a HP. Two patients in Group C, but none in Group DCS experienced anastomotic leakage (AI). ICU and hospital stay was median (range) 2 (1–10) and 17.5 (12–43) in DCS and 2 (1–62) and 22 (13–65) days in group C. In Group DCS 8% (1/12) patients was discharged with a stoma versus 57% (4/7) in Group C (p = 0.038, n.s., α = 0.025); one patient died before discharge. The odds ratio (95% confidence interval) for discharge with a stoma is 0.068 (0.005–0.861). Intent to treat analysis: A PA was performed in 90% (9/10) of patients randomized to DCS, one patient died before the second look, and one patient received a HP. In group C, 70% (7/10) were treated with PA and 30% (3/10) with HP. 29% (2/7) experienced AI treated with protective ileostomy. In group DCS, 9% (1/11) were discharged with a stoma versus 40% (4/10) in group C (p = 0.14, n.s.). The odds ratio for discharge with a stoma is 0.139 (0.012–1.608).ConclusionThis is the first prospectively randomized controlled study showing that damage control surgery in perforated diverticulitis Hinchey III and IV enhances reconstruction of bowel continuity and can reduce the stoma rate at discharge.
The Policies for the Disclosure of Funding and Conflict of Interest in Surgery Journals: A Cross‐Sectional Survey
Authors: El Moheb Mohamad , Karam Basil S. , Assi Lama , Armache Maria , Khamis Assem M. , Akl Elie A. 
Published: September 2020

AbstractBackgroundIndustry through its funding of research and through its relationships with study authors can influence the results of research. Most journals have policies for reporting funding and disclosing conflict of interest (COI) to mitigate the influence of industry on research. The objective of this study is to assess the policies of surgery journals for the reporting of funding and the disclosure of COI.MethodsWe described the prevalence and characteristics of funding and COI policies of journals indexed under “Surgery” in the Journal Citation Reports. We extracted data from publicly available information and through simulation of manuscript submission.ResultsOf the 186 eligible journals, 171 (92%) had policies for reporting of funding. None of the policies described procedures to deal with non‐reporting or underreporting of funding. Of the 186 journals, 183 (99%) had a policy for disclosure of COI. All journals with a COI policy required disclosure of financial interest, while 96 (52%) required the disclosure of non‐financial interests. Only 24 (13%) policies described how non‐disclosure of COI affects the editorial process, and none described procedures to verify COI disclosure. Of the policies that required disclosing COI, 94 (51%) also required reporting the source of financial COI.ConclusionsMost journals have policies for reporting of funding and disclosure of financial COI. However, many do not have clear policies for disclosing non‐financial COI. Major limitations in the policies include the lack of processes for the verification of disclosed interests and for dealing with underreporting of funding and of COI.
On‐Site Monitoring of Postoperative Bile Leakage Using Bilirubin‐Inducible Fluorescent Protein
Authors: Kono Yoshiharu , Ishizawa Takeaki , Kokudo Norihiro , Kuriki Yugo , Iwatate Ryu J. , Kamiya Mako , Urano Yasuteru , Kumagai Akiko , Kurokawa Hiroshi , Miyawaki Atsushi , Hasegawa Kiyoshi 
Published: September 2020

AbstractBackgroundBile leakage is the most common postoperative complication associated with hepatobiliary and pancreatic surgery. Until now, however, a rapid, accurate diagnostic method for monitoring intraoperative and postoperative bile leakage had not been established.MethodBilirubin levels in drained abdominal fluids collected from 23 patients who had undergone hepatectomy (n = 22) or liver transplantation (n = 1) were measured using a microplate reader with excitation/emission wavelengths of 497/527 nm after applying 5 µM of UnaG to the samples. UnaG was also sprayed directly on hepatic raw surfaces in swine hepatectomy models to identify bile leaks by fluorescence imaging.ResultsThe bilirubin levels measured by UnaG fluorescence imaging showed favorable correlations with the results of the conventional light‐absorptiometric methods (indirect bilirubin: rs = 0.939, p < 0.001; direct bilirubin: rs = 0.929, p < 0.001). Approximate time required for bilirubin measurements with UnaG was 15 min, whereas it took about 40 min with the conventional method at a hospital laboratory. Following administration of UnaG on hepatic surfaces, the fluorescence imaging identified bile leaks not only on the resected specimens but also in the abdominal cavity of the swine hepatectomy models.ConclusionFluorescence imaging techniques using UnaG may enable real‐time identification of bile leaks during hepatectomy and on‐site rapid diagnosis of bile leaks after surgery.
Extending Transition Path Theory: Periodically Driven and Finite-Time Dynamics
Authors: Helfmann Luzie , Ribera Borrell Enric , Schütte Christof , Koltai Péter 
Published: September 2020

AbstractGiven two distinct subsets A, B in the state space of some dynamical system, transition path theory (TPT) was successfully used to describe the statistical behavior of transitions from A to B in the ergodic limit of the stationary system. We derive generalizations of TPT that remove the requirements of stationarity and of the ergodic limit and provide this powerful tool for the analysis of other dynamical scenarios: periodically forced dynamics and time-dependent finite-time systems. This is partially motivated by studying applications such as climate, ocean, and social dynamics. On simple model examples, we show how the new tools are able to deliver quantitative understanding about the statistical behavior of such systems. We also point out explicit cases where the more general dynamical regimes show different behaviors to their stationary counterparts, linking these tools directly to bifurcations in non-deterministic systems.
Normative video head impulse test data in subjects with and without vascular risk factors
Authors: Hansson Anders , Salzer Jonatan 
Published: September 2020

Abstract
Purpose
There is a paucity of age- and vascular risk factor-stratified video head impulse test (vHIT) vestibulo-ocular reflex (VOR) data in the literature. The aim of this study was to investigate the vHIT VOR properties in healthy subjects of different ages and subjects with vascular risk factors.

Methods
This was a prospective observational single-center study at a tertiary referral university hospital in northern Sweden. Healthy participants and subjects with vascular risk factors were investigated with a floor standing external camera vHIT device. Age-stratified mean VOR gain among healthy adults and between group gain and gain asymmetry differences were calculated.

Results
We included eighty-eight healthy adults with a mean (range) age of 50 (22–85) years and n = 48 stroke ward patients with vascular risk factors (but without vestibular disease) with a mean (range) age of 74 (42–92) years. The mean VOR gain of horizontal canals decreased at higher ages in healthy subjects (r = − 0.32, p < 0.01, n = 167 canals). The age-stratified mean (SD) VOR gains were < 30 years: 0.98 (0.07), 30–39 years: 0.97 (0.07), 40–49 years: 0.98 (0.06), 50–59 years: 0.99 (0.06), 60–69 years: 0.93 (0.08), ≥ 70 years: 0.89 (0.15). No consistent differences between healthy subjects and subjects with vascular risk factors were seen except for a trend towards more pronounced gain asymmetries in the latter group.

Conclusions
Age, but not vascular risk factors influence VOR gain. Age-adjusted vHIT-measurements may be useful in acute vertigo stroke risk differentiation.
An advanced shell model for the analysis of geometrical and material nonlinear shells
Authors: Gruttmann F. , Wagner W. 
Published: September 2020

AbstractIn this paper layered shells subjected to static loading are considered. The displacements of the Reissner–Mindlin theory are enriched by a an additional part. These so-called fluctuation displacements include warping displacements and thickness changes. They lead to additional terms for the material deformation gradient and the Green–Lagrangian strain tensor. Within a nonlinear multi-field variational formulation the weak form of the boundary value problem accounts for the equilibrium of stress resultants and couple resultants, the local equilibrium of stresses, the geometrical field equations and the constitutive equations. For the independent shell strains an ansatz with quadratic shape functions is chosen. This leads to a significant improved convergence behaviour especially for distorted meshes. Elimination of a set of parameters on element level by static condensation yields an element stiffness matrix and residual vector of a quadrilateral shell element with the usual 5 or 6 nodal degrees of freedom. The developed model yields the complicated three-dimensional stress state in layered shells for elasticity and elasto-plasticity considering geometrical nonlinearity. In comparison with fully 3D solutions present 2D shell model requires only a fractional amount of computing time.
U–Pb zircon geochronology and phase equilibria modelling of HP-LT rocks in the Ossa-Morena Zone, Portugal
Authors: Akker Ismay Vénice , Tajčmanová Lucie , Marques Fernando O. , Burg Jean-Pierre 
Published: September 2020

AbstractThe Ossa-Morena Zone (OMZ) has a complex geological history including both Cadomian and Variscan orogenic events. Therefore, the OMZ plays an important role in understanding the geodynamic evolution of Iberia. However, the P–T–t evolution of the OMZ is poorly documented. Here, we combine structural and metamorphic analyses with new geochronological data and geochemical analyses of mafic bodies in Ediacaran metasediments (in Iberia known as Série Negra) to constrain the geodynamic evolution of the OMZ. In the studied mafic rocks, two metamorphic stages were obtained by phase equilibria modelling: (1) a high-pressure/low-temperature event of 1.0 ± 0.1 GPa and 470–510 °C, and (2) a medium-pressure/higher-temperature event of 0.6 ± 0.2 GPa and 550–600 °C. The increase in metamorphic temperature is attributed to the intrusion of the Beja Igneous Complex (around 350 Ma) and/or the Évora Massif (around 318 Ma). New U–Pb dating on zircons from the mafic rocks with tholeiitic affinity yields an age between 815 and 790 Ma. If the zircons crystallised from the tholeiitic magma, their age would set a minimum age for the pre-Cadomian basement. The ca. 800 Ma protolith age of HP-LT tholeiitic dykes with a different metamorphic history than the host Série Negra lead us to conclude that: (1) the HP-LT mafic rocks and HP-LT marbles with dykes were included in the Ediacaran metasediments as olistoliths; (2) the blueschist metamorphism is older than 550 Ma (between ca. 790 Ma and ca. 550 Ma, e.g., Cadomian).
Native forests but not agroforestry systems preserve arbuscular mycorrhizal fungal species richness in southern Ethiopia
Authors: Belay Zerihun , Negash Mesele , Kaseva Janne , Vestberg Mauritz , Kahiluoto Helena 
Published: September 2020

AbstractThe rapid conversion of native forests to farmland in Ethiopia, the cradle of biodiversity, threatens the diversity of the arbuscular mycorrhizal fungi (AMF) pivotal to plant nutrition and carbon sequestration. This study aimed to investigate the impact of this land-use change on the AMF species composition and diversity in southern Ethiopia. Soil samples were collected from nine plots in each of three land-use types: native forest, agroforestry, and khat monocropping. The plots of the three land-use types were located adjacent to each other for each of the nine replicates. Three 10 × 10m subplots per plot were sampled. AMF spores were extracted from the soil samples, spore densities were determined, and species composition and diversity were evaluated through morphological analysis. Both spore density and species richness were statistically significantly higher in the native forest than in the agroforestry plots with no clear difference to khat, whereas the true diversity (exponential of Shannon–Wiener diversity index) did not differ among the three land-use types due to high evenness among the species in agroforestry. In total, 37 AMF morphotypes belonging to 12 genera in Glomeromycota were found, dominated by members of the generaAcaulosporaandGlomus. The highest isolation frequency index (78%) was recorded forAcaulospora koskeifrom native forest. Consequently, the agroforestry system did not appear to aid in preserving the AMF species richness of native forests relative to perennial monocropping, such as khat cultivation. In contrast, the native forest areas can serve as in situ genetic reserves of mycorrhizal symbionts adapted to the local vegetative, edaphic, and microbial conditions.
Avoiding unnecessary information loss: correct and efficient model synchronization based on triple graph grammars
Authors: Fritsche Lars , Kosiol Jens , Schürr Andy , Taentzer Gabriele 
Published: September 2020

AbstractModel synchronization, i.e., the task of restoring consistency between two interrelated models after a model change, is a challenging task. Triple graph grammars (TGGs) specify model consistency by means of rules that describe how to create consistent pairs of models. These rules can be used to automatically derive further rules, which describe how to propagate changes from one model to the other or how to change one model in such a way that propagation is guaranteed to be possible. Restricting model synchronization to these derived rules, however, may lead to unnecessary deletion and recreation of model elements during change propagation. This is inefficient and may cause unnecessary information loss, i.e., when deleted elements contain information that is not represented in the second model, this information cannot be recovered easily. Short-cut rules have recently been developed to avoid unnecessary information loss by reusing existing model elements. In this paper, we show how to automatically derive (short-cut) repair rules from short-cut rules to propagate changes such that information loss is avoided and model synchronization is accelerated. The key ingredients of our rule-based model synchronization process are these repair rules and an incremental pattern matcher informing about suitable applications of them. We prove the termination and the correctness of this synchronization process and discuss its completeness. As a proof of concept, we have implemented this synchronization process in eMoflon, a state-of-the-art model transformation tool with inherent support of bidirectionality. Our evaluation shows that repair processes based on (short-cut) repair rules have considerably decreased information loss and improved performance compared to former model synchronization processes based on TGGs.