bluuebunny/crossref_metadata_2025_split huggingface dataset:
Report of “Satisfaction” survey amongst Public Health Services Nurses in Port Said.
Authors: Bellizzi Saverio , Padrini Susanna 
Published: November 2020

Abstract
BACKGROUND: There is a paucity of evidence regarding nurses’ experience in different areas of Egypt. A previous pilot unpublished study conducted in the Port Said Technical Nursing Institute, and based on 36 participants, showed almost half of nurses satisfied with their job, as well as salary and work-load as main reason for dissatisfaction as the main problems. We explored job satisfaction of nurses working in public health services of the Port Said Governorate and inform future healthcare provision and policy.METHODS: A Cross sectional study including nurses of different Units was conducted. Questionnaires were delivered in a sample of primary health care facilities as well as in the Governorate Public Hospital. Following literature review eight components were identified as contributors to job satisfaction; two closed questions for each of the eight components and two open questions were developed for a total of 18 questions.RESULTS: The final under-study population consisted of 285 individuals. Almost 40% of the participants at the study felt safe in its clinical environment while around 10% completely disagree on this. Almost 70% of participants reported agreement on high work load because of shortage of colleagues in the respective clinical area while almost 60% disagree on the fact they were not able to give proper care because of workload. Almost 85% of nurse under-study reported that salary did not cover their living cost and only 13% of them believed they earned a fair salary. Almost 60% agree on the fact that they have regular opportunities to develop in their career.CONCLUSION: Increasing job satisfaction among nurses in Egypt is critical to ensure quality of care for patients and aspect like salary, rewarding by coordinators and cooperation with colleagues deserve attention.
Can Physical exercise be an effective adjuvant before the potential COVID-19 vaccine? Insights from serological responses and severity of re-infected cases&nbsp;
Authors: AbdelMassih Antoine , Menshawey Rahma , Hozaien Rafeef , Kamel Aya , Mishriky Fady , Nathan Lauren , Yacoub Elaria , Hanoura Aia Mohamed , AlShehry Nada , Menshawey Esraa , El-Husseiny Nadine , Yasser Reem , Arsanyous Mariem , Husseiny Reem J. , Seyam Mahmoud , Massoud Doaa , Ali Nada , Kassim Assem , AmanAllah Mostafa , Elsayed Rokaya , Sheashaa Hesham , Husseiny Yousef , Hassan Nourhan , Badr Kirollos , Elkhateb Amr , Fouad Verina , Elfishawy Mayada , Medhat Omar , Mustafa Mai , Khalil Noha , Elsayed Rawan , Nada Youssef , Elshawarbi Passant , Abdelmoneim Noha , Hassan Nada , Messiha Mariam , Ghazy Marihan , Abdelfatah Emmy , Nasry Febronia , Gayed Ramy , Eesa Marian , Luis Merna , Eskandar Estfana , Yacoub Shenoda , Rajab Maram , Abdelaziz Mariam , Elgamal Nadine , Jaber Hutaf , Tayssir Sara , Michael Mark , Sabry Ahmed , Shehata Joseph , Abdelaziz Rania , Rateb Sherry , El-Maghraby Ahmed , Mahjoub Yara , Amr Alaa , Amin Amin , Kelada Peter , Saud Alaa , Ragab Shahd , Eltaher Basant , Galal Rahma Hassan , Aly Omnya Mahmoud , Aly Taquwa , AbdelHaleem Rana , ElShaarawy Areeg , Mohamed Omnia 
Published: November 2020

Abstract
Background:As more than 37 million confirmed cases and 1 million deaths worldwide from COVID-19, we flied to think about supporting immunity, So, there are more than 150 coronavirus vaccines and clinical trials are being developed. The success of those vaccines depends mainly on immunologic memory. People who are at high risk of re-infection with COVID-19 don’t show any evidence of having B-cell memory. 10-20% of infected patients don’t develop antibody response. randomized controlled trials and cross-sectional studies proved variant results about the effect of chronic exercise on vaccination function.The aim of this review is to suggest that exercise is an important adjuvant strategy for prevention of re-infection and for development of better protective responses following vaccination.Methods:Embase, Medline and the Cochrane Central Register were used to search for specific keywords such as “COVID-19” OR “SARS-CoV-2” AND “Re-infection” for relevant publications up to 1st of Nov. 2020. The systematic review was performed using PRISMA protocol. Results:According to inclusion criteria, 6 case reports from search and one case from a press conference were identified. The average age of re-infected patients was 36 years. The average intervening period between initial infection and reinfection was 105 days. 75% of cases who have been tested for antibodies after 1st infection were negative, and turned seropositive after second infection. 57% of cases developing re-infection had worse clinical manifestation.Conclusion:Regular moderate intensity exercise not only can enhance the secondary antibody response of B cell memory but also decrease the severity of re-infection and the adverse reactogenicity of potential vaccines under development.
Incidence of COVID-19 among people living with HIV in Southern Spain
Authors: Fernandez-Fuertes Marta , Rodriguez-Pineda Elena , Fuentes-Lopez Ana , Corma-Gomez Anaïs , Rincon Pilar , Serrano-Conde Esther , Real Luis M , Garcia Federico , Macias Juan , Pineda Juan A 
Published: November 2020

Abstract
Objective and Design: The incidence of SARS-CoV-2 infection among people living with HIV (PLWH) has been estimated on the basis of reported symptomatic clinical cases. However, as asymptomatic cases are common and there have been limitations of health care systems for COVID-19 microbiological diagnosis, these estimations may be misleading. The availability of reliable serology for the diagnosis of COVID-19 may overcome this drawback. This study was carried out in order to reveal the actual incidence of SARS-CoV-2 infection in PLWH in Southern Spain.Methods: This is a prospective cohort study including HIV infected patients from the Unit of Infectious Diseases of a university hospital in Seville, Southern Spain. Patients were enrolled in the study if 1) they had attended the outpatient clinic from September 1st to December 31st, 2019 (baseline), and 2) had a subsequent evaluation from March 1st to June 30th, 2020 (intra-pandemic). Serum antibodies against SARS-CoV-2 were determined in baseline and intra-pandemic samples.Results: 326 patients were included in the study. Of them, 4 (1.25% [95% CI: 0.3%-3.1%]) developed COVID-19. One patient developed bilateral pneumonia and died. The remaining three showed mild respiratory symptoms suggesting COVID-19. No asymptomatic SARS-CoV-2 infection was observed in this study. No patient with COVID-19 was tobacco smoker. The incidence of COVID-19 among non-smokers was 2.5% (95% CI [0.6%-6%], p=0.057 versus smokers).Conclusions: The incidence of COVID-19 among PLWH in our area was low and similar to that observed in the general population. The frequency of asymptomatic cases might be lower than in patients without HIV infection. Tobacco smoking could be associated to a lower incidence of COVID-19.
FOUR score versus GCS in patients with traumatic brain injury in the prehospital setting
Authors: Furman Matej Rubelli , Gorenjak Mario , Ravnik Janez 
Published: November 2020

Abstract
Background: In the last few decades, different coma scoring scales have been proposed. The purpose of this study is to compare two coma scales: the GCS (Glasgow Coma Scale) and the FOUR score (Full Outline of UnResponsiveness score), aiming to examine which scale is better for predicting outcome in traumatic brain injury (TBI) patients in the prehospital setting.Methods: We evaluated the GCS and FOUR scores in the prehospital setting at three different prehospital timepoints, and we reassessed the scores in surviving patients 24 hours, one month and three months after the injury. Then, we compared the outcomes.We used the χ² method, and based on the analysis with the best cut-off point for each model, we calculated the sensitivity, specificity and correct prediction of outcomes with four severity scores. The Youden index, Z score, McNemar's test and ROC curve were also assessed. P < 0.05 was considered statistically significant. Both scales were ranked with gain ratios.Results: We included 200 TBI patients who were treated in a prehospital setting by a prehospital specialized medical unit. In terms of the predictions of positive outcomes, our study showed the following:1. Twenty-four hours after the injury, the best cut-off points obtained were from the FOUR 1 and GCS 1 models.2. One month after the injury, the best cut-off points obtained were from the following models: FOUR 2 and GCS 3 as well as FOUR 3 and GCS 3.3. Three months after the injury, the best cut-off points obtained were from the following models: FOUR 2 and GCS 1, FOUR 3 and GCS 1, and GCS 1 and GCS 2.Conclusions: In our study, the results of our research confirm that there are no practical or clinical differences between the GCS and FOUR scores in terms of predicting morality outcomes 24 hours, one month, and three months after injury. No statistically significant differences were found in the Youden index or the area under the ROC curve 24 hours, one month or three months after the injury.
Efficacy of the Manchester Short Splint versus traditional dorsal splint for rehabilitation of Zone II flexor tendon repairs: study protocol for a randomized controlled trial
Authors: Lees Vivien , O'Brien Denise , Redvers-Chubb Karen 
Published: November 2020

Abstract
Background: A previously reported audit of use of the Manchester Short Splint versus the traditional long dorsal forearm splint for rehabilitation of zone II flexor tendon repairs suggested that patient outcomes were enhanced by use of the short splint. Specifically, there was less flexion contracture at the proximal interphalangeal joints at 6 and 12 weeks with greater final range of motion (Strickland assessment). Importantly, there was no evidence of excess tendon ruptures complicating use of the short splint.Methods: The present study is designed as a single-centre randomized controlled trial to compare the two splints [Clinical Evidence Level 2 as patient and treating therapists are aware of which splint is in use]. The study is framed to demonstrate superiority of the short splint intervention over the long splint. Surgery is standardized with respect to the type of repair used. Inclusion criteria for the trial include single finger flexor tendon injury of zone II with up to one but not two simultaneous digital nerve injuries operated on within 4 days of the injury date. Exclusions include children, more complex injuries, those unable to give consent or otherwise co-operate with the trial protocol. Patients are recruited at their first hand therapy visit having been provided with information about the trial by one of the Site Investigators during their hospital admission. The consenting patient is randomized into one of two splint groups. Assessments at 6 and 12 weeks include range of interphalangeal joint motion (TAM), patient reported outcomes (PEM, Quick Dash, pain scales) and grip strength (12 weeks only). Adverse events related and unrelated are documented in line with GCP protocols and patients managed according to clinical indications.Discussion: The present study aims to determine the efficacy of the short splint versus the traditional splint in rehabilitation of Zone II flexor tendon repair. Previous work was in the form of an audit and it is clearly desirable that a more rigorous study is undertaken to address the efficacy or otherwise of the short splint in the context of a clinical trial and to inform development of a multi-centre study.Trial registration: ClinicalTrials.gov Identifier: NCT0385021021.2.19 Retrospectively registeredhttps://clinicaltrials.gov/ct2/results?cond=&term=NCT03850210&cntry=&state=&city=&dist= See website for WHO Trial Registration Data SetTrial Status: Recruitment of first patient 31.3.15. Recruitment completed 6.4.20 subsequent to first submission of manuscript 3.4.20. Study is ongoing for subsequent patient review and measurements as protocol for the subsequent 12 week period and will conclude 29.6.20.
Women's empowerment for abortion and family planning decision making among marginalized women in Nepal: a mixed method study
Authors: KC Heera , Shrestha Mangala , Pokharel Nirmala , Niraula Surya Raj , Pyakurel Prajjwal , Parajuli Surya Bahadur 
Published: November 2020

Abstract
Background: Women’s empowerment is multidimensional. Women’s education, employment, income, reproductive healthcare decision making, household level decision making and social status are vital for women’s empowerment. Nepal is committed to achieving women empowerment and gender equality, which directly affects the reproductive health issues. This can only be achieved by addressing the issues of the poor and marginalized communities. In this context, we aimed to find the association of women’s empowerment with abortion and family planning decision making among marginalized women in Nepal. Methods: A cross sectional study was conducted at selected municipalities of Morang district of Nepal from February 2017 to March 2018. A mixed method approach was used, where 316 married marginalized women of reproductive age (15-49 years) and 15 key informant interviews from representative healthcare providers and local leaders were taken. From key informants, data were analysed using the thematic framework method. Findings obtained from two separate analyses were drawn together and meta inferences were made. Results: Women’s empowerment was above average, at 50.6%. Current use of modern contraceptives were more among below average empowerment groups (p 0.041, OR 0.593 C.I. 0.36-0.98). We could not find any statistically significant differences among levels of women’s empowerment, including those women with abortion knowledge (p 0.549); family planning knowledge (p 0.495) and women’s decision for future use of modern contraceptives (p 0.977). Most key informants reported that unsafe abortion was practiced. Conclusions: Women’s empowerment has no direct role for family planning and abortion decision making at marginalized communities of Morang district of Nepal. However, different governmental and non-governmental organizations influence woman for seeking health care services and family planning in rural community of Nepal irrespective of empowerment status.
A multidisciplinary approach to identify priority areas for the conservation of a vulnerable family of fishes in Spanish Marine National Parks
Authors: Oliver Miquel Planas , Piñeiro-Corbeira Cristina , Bouza Carmen , Castejón-Silvo Inés , Vera Manuel , Regueira Marcos , Ochoa Verónica , Bárbara Ignacio , Terrados Jorge , Chamorro Alexandro , Barreiro Rodolfo , Hernández-Urcera Jorge , Alejo Irene , Nombela Miguel , García Manuel Enrique , Pardo Belén G. , Peña Viviana , Díaz Pilar , Cremades Javier , Morales-Nin Beatriz 
Published: November 2020

Abstract
Background: Syngnathid fishes (Actinopterygii, Syngnathidae) are flagship species strongly associated with seaweed and seagrass habitats. Seahorses and pipefishes are highly vulnerable to anthropogenic and environmental disturbances, but most species are currently Data Deficient according to the IUCN (IUCN, 2019), requiring more biological and ecological research. This study provides the first insights into syngnathid populations in the two marine Spanish National Parks (PNIA –Atlantic- and PNAC –Mediterranean). Fishes were collected periodically, marked, morphologically identified, analysed for size, weight, sex and sexual maturity, and sampled for stable isotope and genetic identification. Due the scarcity of previous information, habitat characteristics were also assessed in PNIA. Results: Syngnathid diversity and abundance were low, with two species identified in PNIA (Hippocampus guttulatus and Syngnathus acus) and four in PNAC (S. abaster, S. acus, S. typhle and Nerophis maculatus). Syngnathids from both National Parks (NP) differed isotopically, with much lower δ15N in PNAC than in PNIA. The dominant species were S. abaster in PNAC and S. acus in PNIA. Syngnathids preferred less exposed sites in macroalgal assemblages in PNIA and Cymodocea meadows in PNAC. The occurrence of very large specimens, the absence of small-medium sizes and the isotopic comparison with a nearby population suggest that the population of Syngnathus acus (the dominant syngnathid in PNIA) mainly comprised breeders that migrate seasonally. Novel 16S rDNA haplotypes and sequence variants were detected for H. guttulatus, N. maculatus, S. acus, and S. abaster. Our data suggest the presence of a cryptic Syngnathus species in PNAC. Conclusions: This is the first multidisciplinary approach to the study of syngnathids in Spanish marine NPs. Habitat preferences and population characteristics in both NPs differed. Further studies are needed to assess potential species misidentifications of genus Syngnathus in PNAC, and migratory events in PNIA. We propose several preferential sites in both NPs for future monitoring of syngnathid populations and some recommendations for their conservation.
The Efficacy and Safety of Utilizing Mobile Phone–Based&nbsp;Programs and Motion-Capture Devices for Telerehabilitation After Arthroscopic Repair of Rotator Cuff Tear: Study Protocol for a Randomized Controlled Trial
Authors: Zhang Yuanhao , Hou Jingyi , Li Fangqi , Zhang Congda , Yang Yaping , Long Yi , Tang Yiyong , Yang Rui 
Published: November 2020

Abstract
Background: Rotator cuff tear is one of the most common diseases in orthopedics, which seriously affects the quality of patients’ lives. And the arthroscopic repair of rotator cuff has recently become more and more popular. Systematic rehabilitation makes great significance for improving the prognosis of postoperative patients. Yet, the traditional outpatient rehabilitation is hard to popularize in developing countries like China due to the limitation of traffic and geography. Given this, we plan to develop a telerehabilitation system to facilitate doctors' remote guidance on patients' rehabilitation.Methods/design: Our study is a single-center, prospective randomized controlled trial. 124 patients who underwent arthroscopic rotator cuff repair will be recruited for the study. They will be randomly divided into 2 groups (62 cases in each group) based on the stratification factors of the operator, operation and preoperative diagnosis. The patients in the control group will get clinic and booklet based rehabilitation treatment after operation. However, patients in the experimental group will receive mobile phone and motion-capture device based programs for telerehabilitation after surgery. The primary outcome will be measured by the American Shoulder and Elbow Surgeons (ASES). Secondary outcomes include the Range of motion (ROM), Visual Analogue Scales (VAS), EuroQol-5 Dimension health questionnaire (EQ-5D), University of California at Los Angeles（UCLA）and the retear rate.Discussion: We hypothesize that patients who utilized mobile phone and motion-capture device based telerehabilitation will benefit more in the range of motion and shoulder function than those who received outpatient and manual based rehabilitation. If the hypothesize was confirmed, we could facilitate telerehabilitation for doctors and overcome the geographical and traffic limitations of traditional clinical based rehabilitation.Trial registration: ChiCTR.org.cn, ChiCTR2000030150, Registered on 24 February 2020
Effects of transcranial direct current stimulation (tDCS) on posture, movement planning, and execution during standing voluntary reach following stroke
Authors: Yang Chieh-ling , Gad Alon , Creath Robert A. , Magder Laurence , Rogers Mark W. , Waller Sandy McCombe 
Published: November 2020

Abstract
Background: Impaired movement preparation of both anticipatory postural adjustments and goal directed movement as shown by a marked reduction in the incidence of StartReact responses during a standing reaching task was reported in individuals with stroke. We tested how transcranial direct current stimulation (tDCS) applied over the region of premotor areas (PMAs) and primary motor area (M1) affect movement planning and preparation of a standing reaching task in individuals with stroke. Methods: Each subject performed two sessions of tDCS over the lesioned hemisphere on two different days: cathodal tDCS over PMAs and anodal tDCS over M1. Movement planning and preparation of anticipatory postural adjustment-reach sequence was examined by startReact responses elicited by a loud acoustic stimulus of 123 dB. Kinetic, kinematic, and electromyography data were recorded to characterize anticipatory postural adjustment-reach movement response. Results: Anodal tDCS over M1 led to significant increase of startReact responses incidence at loud acoustic stimulus time point – 500 ms. Increased trunk involvement during movement execution was found after anodal M1 stimulation compared to PMAs stimulation. Conclusions: The findings provide novel evidence that impairments in movement planning and preparation as measured by startReact responses for a standing reaching task can be mitigated in individuals with stroke by the application of anodal tDCS over lesioned M1 but not cathodal tDCS over PMAs. This is the first study to show that stroke-related deficits in movement planning and preparation can be improved by application of anodal tDCS over lesioned M1.Trial registration: ClinicalTrial.gov, NCT04308629, Registered 16 March 2020 - Retrospectively registered, https://www.clinicaltrials.gov/ct2/show/NCT04308629.
Identification of differentially expressed genes, signaling pathways and immune infiltration in rheumatoid arthritis by integrated bioinformatics analysis
Authors: Ge Yanzhi , Zhou Li , Chen Zuxiang , Mao Yingying , Li Ting , Tong Peijian , Shan Letian 
Published: November 2020

Abstract
Background: The disability rate associated with rheumatoid arthritis (RA) ranks high among inflammatory joint diseases. However, the cause and potential molecular events are as yet not clear. Here, we aimed to identify differentially expressed genes (DEGs), pathways and immune infiltration involved in RA utilizing integrated bioinformatics analysis and investigating potential molecular mechanisms. Materials and methods: The expression profiles of GSE55235, GSE55457, GSE55584 and GSE77298 were downloaded from the Gene Expression Omnibus database, which contained 76 synovial membrane samples, including 49 RA samples and 27 normal controls. The microarray datasets were consolidated and DEGs were acquired and further analyzed by bioinformatics techniques. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses of DEGs were performed using R (version 3.6.1) software, respectively. The protein-protein interaction (PPI) network of DEGs were developed utilizing the STRING database. Finally, the CIBERSORT was used to evaluate the infiltration of immune cells in RA. Results: A total of 828 DEGs were recognized, with 758 up-regulated and 70 down-regulated. GO and KEGG pathway analyses demonstrated that these DEGs focused primarily on cytokine receptor activity and relevant signaling pathways. The 30 most firmly related genes among DEGs were identified from the PPI network. The principal component analysis showed that there was a significant difference between the two tissues in infiltration immune. Conclusion: This study shows that screening for DEGs, pathways and immune infiltration utilizing integrated bioinformatics analyses could aid in the comprehension of the molecular mechanisms involved in RA development. Besides, our study provides valuable data related to DEGs, pathways and immune infiltration of RA and may provide new insight into the understanding of molecular mechanisms.