bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of perioperative factors on nadir serum prostate‐specific antigen levels after holmium laser enucleation of prostate
Authors: Martos Mary , Katz Jonathan E. , Parmar Madhumita , Jain Anika , Soodana‐Prakash Nachiketh , Punnen Sanoj , Gonzalgo Mark L. , Miao Feng , Reis Isildinha M. , Smith Nicholas , Shah Hemendra N. 
Published: January 2021

AbstractObjectiveTo investigate the relationship of preoperative prostate size, urinary retention, positive urine culture, and histopathological evidence of prostatitis or incidental prostate cancer on baseline and 3‐month nadir prostate‐specific antigen (PSA) value after Holmium laser enucleation of prostate (HoLEP).Patients and methodsData from 90 patients who underwent a HoLEP by En‐bloc technique were analyzed. PSA values at baseline and at 3‐month follow‐up, preoperative urinary retention and urine culture status, weight of resected tissue, and histopathological evidence of prostatitis or prostate cancer were recorded. We performed univariable and multivariable gamma‐regression analyses to determine the impact of the aforementioned perioperative variables on preoperative PSA, 3‐month postoperative PSA, and change in PSA.ResultsSerum PSA reduced significantly at 3 months from 6.3 ± 5.9 ng/mL to 0.6 ± 0.6 ng/mL. On both univariable and multivariable analysis, 3‐month nadir level was independent of all preoperative factors examined, except preoperative urinary retention status. Although patients with smaller prostate (resected tissue weight <40 g) had less percentile reduction in PSA when compared with those with larger prostate (resected tissue weight >80 g) (77.67% vs 89.06%; P < .001), patients from both these groups noted a similar PSA nadir level after 3 months (0.54 vs 0.56 ng/dL). The drop in PSA level after HoLEP remained stable up to 1‐year follow‐up.ConclusionsPSA nadir 3 months after HoLEP remains relatively consistent across patients, regardless of preoperative prostate size, PSA value, urine culture status, and histopathological evidence of prostatitis or incidental prostate cancer.
Genetic progress in grain yield and the associated physiological traits of popular wheat in southwestern China from 1969 to 2012
Authors: Liu Miao , Tong Hanwen , Liu Yubin , Li Chaosu , Wu Xiaoli , Li Ming , Li Xuyi , Tang Yonglu 
Published: January 2021

AbstractKnowledge about the key traits related to genetic gains in grain yield (GY) is necessary for understanding the main yield‐limiting factors and guiding future wheat (Triticum aestivum L.) breeding. The objective of this research was to investigate the genetic progress in GY and the associated physiological traits in popular wheat cultivars released from 1969 to 2012 in southwestern China. Field experiments included eight representative cultivars that were evaluated at three experimental sites for three growing seasons. Grain yield increased at a linear rate of 0.69% or 52.52 kg ha−1 yr−1, which was mainly attributed to the increases in dry matter (DM) accumulation at maturity, harvest index (HI), and thousand‐kernel weight (TKW). The soil and plant analyzer development (SPAD) values of flag and penultimate leaves at anthesis increased with the year of release and were significantly related to GY. Significant genetic gains were made in both nonstructural carbohydrate (NSC) translocation and NSC translocation efficiency from anthesis to maturity, and there was a trend over time towards a high net photosynthetic rate (Pn) of flag leaf and canopy apparent photosynthesis (CAP) at anthesis and at 30 d post‐anthesis (DPA). In addition, the linear increases in N uptake efficiency and N utilization efficiency were both significant and positive related to GY. Therefore, these key physiological traits can be used as selection criteria for further improving yield potential. Our results also reveal the potential for using synthetic hexaploid wheat in high‐yielding wheat breeding.
Is orthorexia nervosa a healthy way of being or a mental health disorder? Commentary on He et al. (2020)
Authors: Hay Phillipa 
Published: January 2021

AbstractOrthorexia nervosa is a new syndrome that has seen a marked increase in research in the past decade. Very high prevalence estimates in non‐clinical populations have fuelled the debate as to whether it is a disorder in its own right, or only a problem when occurring in the context of another mental health or eating disorder. More recent assessment instruments have gone some way to address this issue. However, He et al.'s (2020, International Journal of Eating Disorder) study in older East Asian persons was not supportive of orthorexia nervosa as a disorder. Rather, people with orthorexia nervosa had better physical and mental health and lower or similar levels of eating disorder features such as body dissatisfaction when compared with people who did not have orthorexia nervosa. Albeit that selection bias in participant recruitment may in part explain their findings, the status of orthorexia nervosa is unresolved. Further studies need to employ appropriate instruments that measure psychopathology and function more broadly and investigate people with orthorexia nervosa symptoms in representative populations with longitudinal designs. The last is critical, as the most compelling evidence supporting a disorder is to find an adverse health impact over time that can be avoided by appropriate intervention.
In‐process evaluation of continuous generating gear grinding for maintaining workpiece quality and acoustic behavior of gear wheels
Authors: Böttger Jonas , Gentzen Jens , Kimme Simon , Putz Matthias , Drossel Welf‐Guntram 
Published: January 2021

AbstractHard finishing of gearings such as continuous generating gear grinding is highly essential for manufacturers due to increasing demands on gearboxes regarding quality and economical aspects, especially in the growing field of electric mobility. Here, high requirements on the acoustic behavior and low production cost come into conflict in the last stage of manufacturing gearings in a particular way. Against this background, in‐process evaluation methods for manufacturing processes are developed in order to reduce scrap parts and to exploit the process limits by collecting and processing of sensor signal data and by adapting measures based on reasonable process models. This investigation shows how the condition of abrasive tools and workpiece quality are evaluated by means of process near acoustic emission sensor application and motor current of the grinding spindle in order to adapt shifting and feed movement in generating gear grinding process. A calculation method based on a simulation process model is introduced to characterize relevant vibration frequency bands and the resulting acoustically effective waviness on tooth flanks, depending on workpiece and process parameters. Appropriate adaption of the grinding process for increasing productivity while maintaining workpiece quality is based on the findings of an intelligent in‐process evaluation.
Reducing l‐lactate release from hippocampal astrocytes by intracellular oxidation increases novelty induced activity in mice
Authors: Vaccari Cardoso Barbara , Shevelkin Alexey V. , Terrillion Chantelle , Mychko Olga , Mosienko Valentina , Kasparov Sergey , Pletnikov Mikhail V. , Teschemacher Anja G. 
Published: January 2021

AbstractAstrocytes are in control of metabolic homeostasis in the brain and support and modulate neuronal function in various ways. Astrocyte‐derived l‐lactate (lactate) is thought to play a dual role as a metabolic and a signaling molecule in inter‐cellular communication. The biological significance of lactate release from astrocytes is poorly understood, largely because the tools to manipulate lactate levels in vivo are limited. We therefore developed new viral vectors for astrocyte‐specific expression of a mammalianized version of lactate oxidase (LOx) from Aerococcus viridans. LOx expression in astrocytes in vitro reduced their intracellular lactate levels as well as the release of lactate to the extracellular space. Selective expression of LOx in astrocytes of the dorsal hippocampus in mice resulted in increased locomotor activity in response to novel stimuli. Our findings suggest that a localized decreased intracellular lactate pool in hippocampal astrocytes could contribute to greater responsiveness to environmental novelty. We expect that use of this molecular tool to chronically limit astrocytic lactate release will significantly facilitate future studies into the roles and mechanisms of intercellular lactate communication in the brain.
Clean version: Electrospun fibrinogen scaffolds from discarded blood for wound healing
Authors: Yang Long , Sun Yu , Zou Qiang , Lu Tao , Wang Weiyu , Ma Minxian , He Zhixu , Liu Qin , Ye Chuan 
Published: January 2021

AbstractImmediate reutilization of discarded blood from surgery has not received much attention, leading to the waste of a large amount of autologous blood. We used a concentration gradient and high‐voltage electrospinning technology to immediately prepare a scaffold material with high biological activity but without immunogenicity from autologous waste blood collected during surgery. Here, we fabricated and characterized a 90 mg/mL group, 110 mg/mL group, and 130 mg/mL group of fibrinogen (FBG) scaffolds. Analyses revealed that the FBG scaffolds had good film‐forming properties and a clear fiber structure. in vitro cell viability experiments confirmed that the cells showed an increasing trend with increasing FBG concentrations. The cells grew well in the scaffold material and secreted more cell matrix. When human bone mesenchymal stem cells (hBMSCs) were cocultured with the scaffold material, the hBMSCs expressed osteogenic and chondrogenic biomarkers. The cellular scaffold complexes from the 3 groups were implanted in four full‐thickness round wounds (Φ12 mm) on the dorsal back of each rat, the 130 mg/mL group showed a 90% reduction in wound size and the data compared to other groups were better at 14 day. These results suggest that electrospinning technology‐based FBG scaffold materials derived from autologous waste blood may become an ideal tissue engineering scaffold and can be immediately used for autologous hemostasis, anti‐adhesion films, and wound dressing in surgery.
Prognostic Features in Intermediate‐Size Supraglottic Tumors Treated With Open Supraglottic Laryngectomy
Authors: Damiani Marialessia , Mercante Giuseppe , Abdellaoui Mohammed , Guerlain Joanne , Moya‐Plana Antoine , Casiraghi Odile , Temam Stéphane , Tao Yungan , Gorphe Philippe 
Published: January 2021

Objectives/HypothesisWe investigated growth patterns and pathological features in intermediate‐size laryngeal carcinoma amenable to supraglottic laryngectomy.Study designRetrospective cohort study.MethodsWe reviewed patients who underwent an open partial horizontal laryngectomy (OPHL) type I. We analyzed pathological data, tumor sizes, overall survival, disease‐specific survival, local control, and laryngeal preservation. Results were stratified between three groups: group I comprised patients with endolaryngeal carcinoma, group II comprised patients with anterior epilaryngeal carcinoma who underwent an OPHL type I + base of tongue (BOT), group III comprised patients with lateral epilaryngeal carcinoma who underwent an OPHL type I + pyriform sinus (PIR).ResultsSixty‐eight patients were analyzed. The 5‐year rates of overall survival, disease‐specific survival, local control, and laryngeal preservation were 68.4%, 83.7%, 91.6%, and 98.3%, respectively. The tumor sizes at pathological examination were similar between the three groups (mean 27 mm, P = .80) and were associated with pathological features, notably pre‐epiglottic space (PES) invasion (24.9 mm vs. 32.2 mm, P = .01), occult invaded lymph nodes (22.6 mm vs. 29.9 mm, P = .03), and trends for margins status (26.5 mm vs. 29.3 mm, P = .45). The risks of PES invasion, occult lymph nodes, and positive margins, respectively, predominated in group I (41.7%), group II (56.3%), and group III (23.3%).ConclusionIn intermediate‐size tumors amenable to supraglottic laryngectomy, pathological features are associated with tumor size according to group stratification based on tumor location.Level of Evidence4 Laryngoscope, 131:E1980–E1986, 2021
The variable‐extended immersed boundary method for compressible gaseous reactive flows past solid bodies
Authors: Wang Jian‐Hang , Zhang Chi 
Published: January 2021

AbstractAn immersed boundary method (IBM) has been developed to handle the solid body embedded flowfield simulation for compressible reactive flows, paving the way of application for a wide range of fluid–solid interaction problems. Previously, the Brinkman penalization method (BPM), originated from porous media flows, has been successfully used for incompressible Navier–Stokes equations by adding penalization terms to momentum equations. However, it is nontrivial to solve the compressible form due to the penalized continuity equation that usually poses severe numerical stiffness. In order to circumvent this issue, an extending procedure for relevant variables from the fluid to solid domain is considered, by analyzing the ordinary differential equations remained after operator splitting. Density can be then determined with the help of an equation of state (EoS). Meanwhile, efforts of enforcing the Neumann boundary condition, for example, the adiabatic wall condition, on the fluid–solid interface can be minimized by extending temperature across the interface directly. One more advantage of the extending step lies in that it can quickly reach a steady state when performed within a narrow band around the interface. Implemented into an adaptive Cartesian grid‐based flow solver for compressible Navier–Stokes equations with chemical reaction source terms, the present variable‐extended IBM is validated by numerical examples ranging from single‐species nonreactive to multispecies detonative flows in one‐ and two‐dimensional domains. Numerical results show (1) the successful specification of slip or nonslip, adiabatic or isothermal wall condition on the fluid–solid interface and (2) loss of total energy in the original BPM being avoided and the numerical accuracy being improved especially for energy‐sensitive reactive flows.
Disforming the Kerr metric
Authors: Anson Timothy , Babichev Eugeny , Charmousis Christos , Hassaine Mokhtar 
Published: January 2021

AbstractStarting from a recently constructed stealth Kerr solution of higher order scalar tensor theory involving scalar hair, we analytically construct disformal versions of the Kerr spacetime with a constant degree of disformality and a regular scalar field. While the disformed metric has only a ring singularity and asymptotically is quite similar to Kerr, it is found to be neither Ricci flat nor circular. Non-circularity has far reaching consequences on the structure of the solution. As we approach the rotating compact object from asymptotic infinity we find a static limit ergosurface similar to the Kerr spacetime with an enclosed ergoregion. However, the stationary limit of infalling observers is found to be a timelike hypersurface. A candidate event horizon is found in the interior of this stationary limit surface. It is a null hypersurface generated by a null congruence of light rays which are no longer Killing vectors. Under a mild regularity assumption, we find that the candidate surface is indeed an event horizon and the disformed Kerr metric is therefore a black hole quite distinct from the Kerr solution.
Gadolinium retention within multiple rat organs after intra-articular administration of gadolinium-based contrast agents
Authors: Ringler Michael D. , Rhodes Nicholas G. , Ayers-Ringler Jennifer R. , Jakaitis Daniel R. , McDonald Robert J. , Kallmes David F. , McDonald Jennifer S. 
Published: January 2021

Abstract
Objective
To characterize the extent of retention and biodistribution of gadolinium (Gd) following intra-articular (IA) injection of linear and macrocyclic gadolinium-based contrast agents (GBCAs) into the knee joint of a rat model.

Materials and methods
Fifteen Wistar rats were divided into five groups and underwent fluoroscopically-guided injections of both knee joints of (1) clinical 1:200 dilution (low dose, LD) gadodiamide (linear GBCA), (2) LD gadobutrol (macrocyclic GBCA), (3) undiluted (high dose, HD) gadodiamide, (4) HD gadobutrol, and (5) saline. Gd concentrations were quantified by inductively coupled plasma mass spectrometry in (1) blood and urine samples obtained over a 72 h period and (2) knee joint tissues, brain, kidney, and bone marrow at 3 days post-injection.

Results
Both HD and LD gadodiamide and gadobutrol were rapidly absorbed from the joint with peak serum and urine concentration at 1 h post-injection, with relatively faster clearance of gadobutrol. All GBCA-exposed groups had detectable levels of Gd in the joint tissues, bone marrow, and/or kidneys (median tissue gadolinium range: 0.1–71 μg Gd/g tissue), with higher amounts observed with gadodiamide versus gadobutrol. Retention within brain tissues was only detected following HD gadodiamide administration but not LD gadodiamide nor HD or LD gadobutrol.

Conclusion
There was rapid systemic absorption, redistribution, and widespread multi-organ retention of Gd following IA injection of both linear and macrocyclic GBCAs, despite substantial amounts of urinary excretion. Higher concentrations of Gd were observed with administration of gadodiamide compared to gadobutrol in most tissues and biofluids.
Topographic organization in the olfactory bulb
Authors: Lodovichi Claudia 
Published: January 2021

AbstractThe ability of the olfactory system to detect and discriminate a broad spectrum of odor molecules with extraordinary sensitivity relies on a wide range of odorant receptors and on the distinct architecture of neuronal circuits in olfactory brain areas. More than 1000 odorant receptors, distributed almost randomly in the olfactory epithelium, are plotted out in two mirror-symmetric maps of glomeruli in the olfactory bulb, the first relay station of the olfactory system. How does such a precise spatial arrangement of glomeruli emerge from a random distribution of receptor neurons? Remarkably, the identity of odorant receptors defines not only the molecular receptive range of sensory neurons but also their glomerular target. Despite their key role, odorant receptors are not the only determinant, since the specificity of neuronal connections emerges from a complex interplay between several molecular cues and electrical activity. This review provides an overview of the mechanisms underlying olfactory circuit formation. In particular, recent findings on the role of odorant receptors in regulating axon targeting and of spontaneous activity in the development and maintenance of synaptic connections are discussed.
Progesterone Attenuates Brain Inflammatory Response and Inflammation-Induced Increase in Immature Myeloid Cells in a Mouse Model
Authors: Gutzeit Ola , Segal Linoy , Korin Ben , Iluz Roee , Khatib Nizar , Dabbah-Assadi Fadwa , Ginsberg Yuval , Fainaru Ofer , Ross Michael G. , Weiner Zeev , Beloosesky Ron 
Published: January 2021

Abstract
Progesterone has been shown to regulate immunity during pregnancy, and progesterone administration may reduce inflammation-induced preterm labor. We sought to determine the maternal brain immune response to LPS-induced inflammation in pregnant and non-pregnant mice and whether additional progesterone supplementation attenuates this response. Pregnant (P: n = 9) and non-pregnant mice (NP: n = 9) were randomized to pretreatment with vaginal progesterone/carrier (Replens), daily from days 13 to 16. On days 15 and 16, LPS/saline was administered by intraperitoneal injection (Replens + saline n = 3; Replens + LPS n = 3; progesterone + LPS n = 3). Mice were sacrificed on day 16 and maternal serum analyzed for IL-6 levels and brains analyzed for nNOS, NF-kB, IL-6 protein levels and for immature myeloid cells (IMCs) and microglial activity. LPS significantly increased brain nNOS, NF-kB, and IL-6 in both NP and P mice, with significantly greater responses in P mice. In both NP and P groups, progesterone significantly attenuated LPS-induced increase of nNOS and NF-kB, however with no effect on serum IL-6. In the NP brains, LPS significantly increased IMC population and progesterone reduced the IMC phenotype to levels similar to controls. In P mice, neither LPS nor LPS + progesterone altered the brain IMC population. LPS significantly increased the microglial activity in both NP and P groups, which was attenuated by progesterone. Progesterone attenuates brain inflammatory response to LPS in both NP and P mice although it has no effect on systemic inflammation. In NP mice, progesterone attenuated the increase in brain IMC following LPS administration. Our results suggest that endogenous progesterone during pregnancy may protect the brain from LPS-induced inflammation.
Mesoscale-dependent near-inertial internal waves and microscale turbulence in the Tsushima Warm Current
Authors: Kawaguchi Yusuke , Wagawa Taku , Yabe Itsuka , Ito Daiki , Senjyu Tomoharu , Itoh Sachihiko , Igeta Yosuke 
Published: January 2021

AbstractThis study examined characteristics of near-inertial internal waves (NIWs) associated with the background mesoscale field near the Tsushima Warm Current. Observational stations off Sado Island were visited recurrently to assess spatiotemporal changes of fine-scale and microscale properties of seawater. Also, NIWs were inspected in terms of relative vorticity and total strain in surface geostrophic motion. During summer expeditions in 2019, current and hydrographic surveys at the rim of an anticyclonic eddy provided clear evidence of downward-travelling NIWs, which were most amplified near the depth of lower pycnocline. The amplification of NIW coincided with elevation in the dissipation rates of turbulent kinetic energy (TKE) and microscale variation of temperature. The fall 2019 expedition found details of wave and turbulence properties associated with the mesoscale structure of paired vortices, where a cyclone and anticyclone were, respectively, adjacent to the east and west. Amplified signals of NIW-related vertical shear and TKE dissipation were found at isopycnals between the dipole cores. From the theoretical perspective of internal wave, the baroclinic term attributable to vertical shear of geostrophic current was interpreted as inducing downward travel of NIW through the lower pycnoclines between the dipole cores. It is also noted that cyclones, passing through the central part of Sea of Japan, can deliver kinetic energy into 10-km scale internal waves as a consequence of interaction between easterly wind and mountainous topography in the Honshu Island.