bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study protocol for the antidepressant advisor (ADeSS): a decision support system for antidepressant treatment for depression in UK primary care: a feasibility study
Authors: Harrison Phillippa , Carr Ewan , Goldsmith Kimberley , Young Allan H , Ashworth Mark , Fennema Diede , Barrett Barbara , Zahn Roland 
Published: May 2020

IntroductionThe Antidepressant Advisor Study is a feasibility trial of a computerised decision-support tool which uses an algorithm to provide antidepressant treatment guidance for general practitioners (GPs) in the UK primary care service. The tool is the first in the UK to implement national guidelines on antidepressant treatment guidance into a computerised decision-support tool.Methods and analysisThe study is a parallel group, cluster-randomised controlled feasibility trial where participants are blind to treatment allocation. GPs were assigned to two treatment arms: (1) treatment-as-usual (TAU) and (2) computerised decision-support tool to assist with antidepressant choices. The study will assess recruitment and lost to follow-up rates, GP satisfaction with the tool and impact on health service use. A meaningful long-term roll-out unit cost will be calculated for the tool, and service use data will be collected at baseline and follow-up to inform a full economic evaluation of a future trial.Ethics and disseminationThe study has received National Health Service ethical approval from the London—Camberwell St Giles Research Ethics Committee (ref: 17/LO/2074). The trial was pre-registered in the Clinical Trials.gov registry. The results of the study will be published in a pre-publication archive within 1 year of completion of the last follow-up assessment.Trial registration numberNCT03628027.
Canadian clinical practice guidelines for the use of plant-based cannabis and cannabinoid-based products in the management of chronic non-cancer pain and co-occurring conditions: protocol for a systematic literature review
Authors: Wright Patrick , Walsh Zach , Margolese Shari , Sanchez Tatiana , Arlt Stephanie , Belle-Isle Lynne , St.Pierre Michelle , Bell Alan , Daeninck Paul , Gagnon Marilou , Lacasse Gary , MacCallum Caroline , Mandarino Enrico , Yale Janet , O'Hara James , Costiniuk Cecilia 
Published: May 2020

IntroductionChronic pain and co-occurring disorders, such as sleep disorders, anxiety, depression, post-traumatic stress disorder and substance use disorders, are among the most common conditions for which cannabis and cannabinoid-based products derived from the cannabis plant (CBP) are used for therapeutic purposes. However, healthcare providers report that they lack sufficient information on the risks, benefits and appropriate use of cannabis and CBP derived from the cannabis plant for therapeutic purposes.Methods and analysisWe will conduct a systematic review of studies investigating the use of cannabis and CBP derived from the cannabis plant for the treatment of chronic pain and co-occurring conditions. Randomised controlled trials, meta-analyses and observational studies will be prioritised. We will exclude reviews of cannabinoid mechanisms of actions, commentary articles and narrative reviews. The primary outcome of interest will be efficacy in relieving chronic pain. Secondary outcomes will be efficacy in ameliorating conditions such as sleep disorders, anxiety, depression, post-traumatic stress disorder and substance use disorders. We will search electronic bibliographic databases including Academic Search Complete, Cochrane Database of Systematic Reviews, Evidence based Medicine Reviewes, OVID Medline, PsychINFO, PubMed, CINAHL and Web of Science. Two reviewers will conduct screening and data collection independently. Study level of bias will be assessed using the Cochrane Risk of Bias Assessment Tool for randomised controlled trials and non-randomised studies. Narrative analysis will be utilised to interpret the data.Ethics and disseminationThe results of this systematic review will inform guideline development for the use of cannabis and CBP derived from the cannabis plant in the management of chronic pain and co-occurring conditions. Areas requiring further study will also be highlighted.PROSPERO registration numberCRD42020135886.
What is the feasibility and observed effect of two implementation packages for stroke rehabilitation therapists implementing upper limb guidelines? A cluster controlled feasibility study
Authors: Jolliffe Laura , Hoffmann Tammy , Churilov Leonid , Lannin Natasha A 
Published: May 2020

BackgroundHand and arm activity after stroke improves with evidence-based rehabilitation. Therapists face known barriers when providing evidence-based rehabilitation and require support to implement guidelines. The aim of this study was to investigate the feasibility of two implementation packages on guideline adherence by occupational therapists and physiotherapists, and explore effect on patient upper limb outcomes.MethodThis was a non-randomised clustered feasibility study of occupational and physiotherapy rehabilitation services (n=3 inpatient and n=3 outpatient services). Services were allocated to one of three groups: (group A) facilitator-mediated implementation package, (group B) self-directed implementation package or (group C) usual care (control); we recruited n=1 inpatient and n=1 outpatient service per group. Outcomes of feasibility, adherence to guidelines (medical file audits) and patient upper limb impairment (Fugl-Meyer Upper Extremity Assessment), activity (Box and Block Test) and practice (minutes/week) were collected at baseline and after 3 months of intervention.Results29 therapists (8 in group A, 13 in groups B and 8 in group C) and 55 patients participated. Both the facilitator-mediated and the self-directed implementation packages were feasible to deliver in the rehabilitation setting. Therapists in group A improved with respect to guideline adherence (medical file audits; median within-group proportion difference of 0.29 (95% CI 0.22 to 0.36, p<0.0001) preintervention to postintervention). No significant within-group differences from baseline to postintervention were found in group B or group C, and no between-group differences were found for upper limb outcomes.ConclusionA facilitator-mediated package was acceptable to therapists working in stroke rehabilitation, and feasibility data suggest increased guideline uptake following implementation. An adequately powered study is planned to understand how to support therapists to provide evidence-based upper limb rehabilitation after stroke.Trial registration numberAustralian New Zealand Clinical Trials Registry (ACTRN12619000596101).
Prompt recognition of infectious pulmonary tuberculosis is critical to achieving elimination goals: a retrospective cohort study
Authors: Heffernan Courtney , Barrie James , Doroshenko Alexander , Egedahl Mary Lou , Paulsen Catherine , Senthilselvan Ambikaipakan , Long Richard 
Published: May 2020

IntroductionAll pulmonary tuberculosis (PTB) cases are presumed to be infectious to some degree. This spectrum of infectiousness is independently described by both the acid-fast bacilli smear and radiographic findings. Smear-positive patients with chest radiographic findings that are typical for adult-type PTB are believed to be most infectious.HypothesisCharacterisation of the presumed most infectious PTB case is possible by reference to readily available clinical features and laboratory results.MethodsRetrospective cohort study of adult, culture-positive PTB cases (151 smear-positive; 162 smear-negative) diagnosed between 1 January 2013 and 30 April 2017 in Canada. We describe cases according to demographic, clinical and laboratory features. We use multivariable multinomial logistic regression to estimate the relative risk ratio (RRR) with 95% CI of features associated with an outcome of smear-positive PTB, characterised by ‘typical’ chest radiograph findings.ResultsBeing Canadian-born, symptomatic, having a subacute duration of symptoms and broad-spectrum antibiotic prescriptions were all more commonly associated with smear-positive than smear-negative disease (36% vs 20%; 95% vs 63%; 88% vs 54%; and 59% vs 28%, respectively). After combining smear status and radiographic features, we show that smear-positive patients with typical chest radiographs were younger, had a longer duration of symptoms (RRR 2.41; 95% CI 1.01 to 5.74 and 2.93; 95% CI 1.20 to 7.11, respectively) and were less likely to be foreign-born, or have a moderate to high-risk factor for reactivation (RRR 0.40; 95% CI 0.17 to 0.92 and 0.18; 95% CI 0.04 to 0.71, respectively) compared with smear-negative patients with atypical chest radiograph findings.ConclusionA clear picture of the presumed most infectious PTB case emerges from available historical and laboratory information; vigilance for this presentation by front-line providers will support elimination strategies aimed at reducing transmission.
Cytotoxic T-cell-related gene expression signature predicts improved survival in muscle-invasive urothelial bladder cancer patients after radical cystectomy and adjuvant chemotherapy
Authors: Eckstein Markus , Strissel Pamela , Strick Reiner , Weyerer Veronika , Wirtz Ralph , Pfannstiel Carolin , Wullweber Adrian , Lange Fabienne , Erben Philipp , Stoehr Robert , Bertz Simone , Geppert Carol Imanuel , Fuhrich Nicole , Taubert Helge , Wach Sven , Breyer Johannes , Otto Wolfgang , Burger Maximilian , Bolenz Christian , Keck Bastian , Wullich Bernd , Hartmann Arndt , Sikic Danijel 
Published: May 2020

BackgroundAssessment of the immune status of muscle-invasive bladder cancer (MIBC) has previously shown to be prognostically relevant after treatment with curative intent. We conducted this study to develop a clinically applicable immune gene expression assay to predict prognosis and adjuvant chemotherapy benefit.Patients and methodsGene expression ofCD3Z,CD8AandCXCL9, immune cell (IC) populations including stromal tumor infiltrating lymphocytes (sTILs), T-cells, natural killer cells (NK-cells), macrophages, Programmed cell death protein 1 positive (PD-1) IC and tumor subtypes (MD Anderson Cancer Center/MDACC-approach) were assessed in 187 MIBC patients (Comprehensive Cancer Center Erlangen-EMN/CCC-EMN-cohort). A gene expression signature was derived by hierarchical-clustering and validated in The Cancer Genome Atlas (TCGA)-cohort. IC populations in the TCGA cohort were assessed via CIBERSORT. Benefit of platinum-containing adjuvant chemotherapy was assessed in a pooled cohort of 125 patients. Outcome measurements were disease specific survival, disease-free survival and overall survival.ResultsThe gene expression signature ofCXCL9,CD3ZandCD8Acorrelates with quantitative amounts of specific IC populations and sTILs (CCC-EMN: ρ-range: 0.44–0.74; TCGA: ρ-range: 0.56–0.82) and allows stratification of three different inflammation levels (inflamed high, inflamed low, uninflamed). Highly inflamed tumors are preferentially basal subtype and show favorable 5-year survival rates of 67.3% (HR=0.27; CCC-EMN) and 55% (HR=0.41; TCGA). Uninflamed tumors are predominantly luminal subtypes and show low 5-year survival rates of 28% (CCC-EMN) and 36% (TCGA). Inflamed tumors exhibit higher levels of PD-1 and Programmed cell death 1 ligand 1 (PD-L1). Patients undergoing adjuvant platinum-based chemotherapy with ‘inflamed high’ tumors showed a favorable 5-year survival rate of 64% (HR=0.27; merged CCC-EMN and TCGA cohort).ConclusionThe gene expression signature ofCD3Z,CD8AandCXCL9can assess the immune status of MIBC and stratify the survival of MIBC patients undergoing surgery and adjuvant platinum-based chemotherapy. Furthermore, the assay can identify patients with immunological hot tumors with particular high expression of PD-L1 potentially suitable for immunotherapy.
Optimized combinatorial pMHC class II multimer labeling for precision immune monitoring of tumor-specific CD4 T cells in patients
Authors: Rockinger Georg Alexander , Guillaume Philippe , Cachot Amélie , Saillard Margaux , Speiser Daniel E , Coukos Georges , Harari Alexandre , Romero Pedro J , Schmidt Julien , Jandus Camilla 
Published: May 2020

BackgroundWith immunotherapy gaining increasing approval for treatment of different tumor types, scientists rely on cutting edge methods for the monitoring of immune responses and biomarker development in patients. Due to the lack of tools to efficiently detect rare circulating human tumor-specific CD4 T cells, their characterization in patients still remains very limited.MethodsWe have used combinatorial staining strategies with peptide major histocompatibility complex class II (pMHCII) multimer constructs of different alleles to establish an optimized staining procedure for in vitro and direct ex-vivo visualization of tumor-specific CD4 T cells, in patient samples. Furthermore, we have generated reversible multimers to achieve optimal cell staining and yet disassemble prior to in vitro cell expansion, thus preventing activation induced cell death.ResultsWe observed a vastly improved detection of tumor-specific, viral-specific and bacterial-specific cells with our optimization methods compared with the non-optimized staining procedure. By increasing the variety of fluorochromes used to label the pMHCII multimers, we were also able to increase the parallel detection of different specificities within one sample, including antigen-specific CD8 T cells. A decrease in cell viability was observed when using the full optimization method, but this was mitigated by the removal of neuraminidase and the use of reversible multimers.ConclusionThis new optimized staining procedure represents an advance toward better detection and analysis of antigen-specific CD4 T cells. It should facilitate state-of-the art precision monitoring of tumor-specific CD4 T cells and contribute to accelerate the use and the targeting of these cells in cancer immunotherapy.
Quark structure of the $$\chi _{\mathrm{c}}(3P)$$ and X(4274) resonances and their strong and radiative decays
Authors: Ferretti J. , Santopinto E. , Anwar M. Naeem , Lu Yu 
Published: May 2020

AbstractWe calculate the masses of $$\chi _{\mathrm{c}}(3P)$$χc(3P) states with threshold corrections in a coupled-channel model. The model was recently applied to the description of the properties of $$\chi _{\mathrm{c}}(2P)$$χc(2P) and $$\chi _{\mathrm{b}}(3P)$$χb(3P) multiplets (Ferretti and Santopinto in Phys Lett B 789:550, 2019]. We also compute the open-charm strong decay widths of the $$\chi _{\mathrm{c}}(3P)$$χc(3P) states and their radiative transitions. According to our predictions, the $$\chi _{\mathrm{c}}(3P)$$χc(3P) states should be dominated by the charmonium core, but they may also show small meson-meson components. The X(4274) is interpreted as a $$c {{\bar{c}}}$$cc¯$$\chi _{\mathrm{c1}}(3P)$$χc1(3P) state. More information on the other members of the $$\chi _{\mathrm{c}}(3P)$$χc(3P) multiplet, as well as a more rigorous analysis of the X(4274)’s decay modes, are needed to provide further indications on the quark structure of the previous resonance.
Detecting/preventing infections, and moving instruction online
Authors: DeFranco Terrence , Roschelle Jeremy 
Published: May 2020

The
Communications
Web site, http://cacm.acm.org, features more than a dozen bloggers in the BLOG@CACM community. In each issue of
Communications
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http://cacm.acm.org/blogs/blog-cacm
Terrence DeFranco suggests the Internet of Things could be keeping us safer, and Jeremy Roschelle airs issues related to online instruction.
Data-driven algorithm design
Authors: Gupta Rishi , Roughgarden Tim 
Published: May 2020

The best algorithm for a computational problem generally depends on the "relevant inputs," a concept that depends on the application domain and often defies formal articulation. Although there is a large literature on empirical approaches to selecting the best algorithm for a given application domain, there has been surprisingly little theoretical analysis of the problem.
We model the problem of identifying a good algorithm from data as a statistical learning problem. Our framework captures several state-of-the-art empirical and theoretical approaches to the problem, and our results identify conditions under which these approaches are guaranteed to perform well. We interpret our results in the contexts of learning greedy heuristics, instance feature-based algorithm selection, and parameter tuning in machine learning.
Pirfenidone alleviates pulmonary fibrosis in vitro and in vivo through regulating Wnt/GSK-3β/β-catenin and TGF-β1/Smad2/3 signaling pathways
Authors: Lv Qun , Wang Jianjun , Xu Changqing , Huang Xuqing , Ruan Zhaoyang , Dai Yifan 
Published: May 2020

Abstract
Background
Pirfenidone (PFD) is effective for pulmonary fibrosis (PF), but its action mechanism has not been fully explained. This study explored the signaling pathways involved in anti-fibrosis role of PFD, thus laying a foundation for clinical application.

Methods
Pulmonary fibrosis mice models were constructed by bleomycin (BLM), and TGF-β1 was used to treat human fetal lung fibroblasts (HLFs). Then, PFD was added into treated mice and cells alone or in combination with β-catenin vector. The pathological changes, inflammatory factors levels, and Collagen I levels in mice lung tissues were assessed, as well as the activity of HLFs was measured. Levels of indices related to extracellular matrix, epithelial-mesenchymal transition (EMT), Wnt/GSK-3β/β-catenin and TGF-β1/Smad2/3 signaling pathways were determined in tissues or cells.

Results
After treatment with BLM, the inflammatory reaction and extracellular matrix deposition in mice lung tissues were serious, which were alleviated by PFD and aggravated by the addition of β-catenin. In HLFs, PFD reduced the activity of HLFs induced by TGF-β1, inhibited levels of vimentin and N-cadherin and promoted levels of E-cadherin, whereas β-catenin produced the opposite effects to PFD. In both tissues and cells, Wnt/GSK-3β/β-catenin and TGF-β1/Smad2/3 signaling pathways were activated, which could be suppressed by PFD.

Conclusions
PFD alleviated pulmonary fibrosis in vitro and in vivo through regulating Wnt/GSK-3β/β-catenin and TGF-β1/Smad2/3 signaling pathways, which might further improve the action mechanism of anti-fibrosis effect of PFD.
Sensitivity of censored data analysis to determine the characteristic value of structural timber
Authors: Pang Sung-Jun , Lee Hyeon-Jeong , Ahn Kyung-Sun , Oh Jung-Kwon 
Published: May 2020

AbstractIn structural timber tests, unintended failure mechanisms occur frequently in specimens and their results are called censored data. There are two censored data analysis: censored maximum likelihood estimation (CMLE) and Kaplan–Meier (KM) method. In this study, the precision of the censored data analysis was investigated to determine the characteristic value, 5th percentile value, of the structural timber. The results show that (1) the 5th percentile value was underestimated by ordinary data analysis methods; maximum likelihood estimation (MLE) and Order statistics. (2) CMLE with 30% lower tail censored data and KM method provided much more precise 5th percentile value. (3) The amount of under-measurement (5 MPa, 10 MPa, and 15 MPa in this simulation study) did not show significant effect on the 5th percentile determination in CMLE and KM method, but the proportion of censored data (percentage of unintended failure specimen; 10%, 20%, 30%, and 40%) affected the determination of 5th percentile value. (4) CMLE with 30% lower tail censored data and KM method showed good agreement in case that the data included unintended failure data up to 20%.
Persistent post-traumatic headache: a migrainous loop or not? The clinical evidence
Authors:   On behalf of the European Headache Federation School of Advanced Studies (EHF-SAS), Labastida-Ramírez Alejandro , Benemei Silvia , Albanese Maria , D’Amico Antonina , Grillo Giovanni , Grosu Oxana , Ertem Devrimsel Harika , Mecklenburg Jasper , Fedorova Elena Petrovna , Řehulka Pavel , di Cola Francesca Schiano , Lopez Javier Trigo , Vashchenko Nina , MaassenVanDenBrink Antoinette , Martelletti Paolo 
Published: May 2020

Abstract
Background
Headache is a common complication of traumatic brain injury. The International Headache Society defines post-traumatic headache as a secondary headache attributed to trauma or injury to the head that develops within seven days following trauma. Acute post-traumatic headache resolves after 3 months, but persistent post-traumatic headache usually lasts much longer and accounts for 4% of all secondary headache disorders.

Main body
The clinical features of post-traumatic headache after traumatic brain injury resemble various types of primary headaches and the most frequent are migraine-like or tension-type-like phenotypes. The neuroimaging studies that have compared persistent post-traumatic headache and migraine found different structural and functional brain changes, although migraine and post-traumatic headache may be clinically similar. Therapy of various clinical phenotypes of post-traumatic headache almost entirely mirrors the therapy of the corresponding primary headache and are currently based on expert opinion rather than scientific evidence. Pharmacologic therapies include both abortive and prophylactic agents with prophylaxis targeting comorbidities, especially impaired sleep and post-traumatic disorder. There are also effective options for non-pharmacologic therapy of post-traumatic headache, including cognitive-behavioral approaches, onabotulinum toxin injections, life-style considerations, etc.

Conclusion
Notwithstanding some phenotypic similarities, persistent post-traumatic headache after traumatic brain injury, is considered a separate phenomenon from migraine but available data is inconclusive. High-quality studies are further required to investigate the pathophysiological mechanisms of this secondary headache, in order to identify new targets for treatment and to prevent disability.
Study on the Color Compensation Effect of Composite Orange-Red Quantum Dots in WLED Application
Authors: Hu Xiaoyue , Xie Yangyang , Geng Chong , Xu Shu , Bi Wengang 
Published: May 2020

AbstractQuantum dots (QDs) as emerging light-converting materials show the advantage of enhancing color quality of white light-emitting diode (WLED). However, WLEDs employing narrow-emitting monochromic QDs usually present unsatisfactory color rendering in the orange region. Herein, composite orange-red QDs (composite-QDs) are developed through mixing CdSe/ZnS-based orange QDs (O-QDs) and red QDs (R-QDs) to compensate the orange-red light for WLEDs. We investigated the effect of self-absorption and fluorescence resonance energy transfer (FRET) process in composite-QDs on the spectral controllability and fluorescent quenching in WLEDs. The concentration and donor/acceptor ratios were also taken into account to analyze the FRET efficiency and help identify suitable composite-QDs for color compensation in the orange-red light region. As the result, the optimized composite-QDs effectively improve the color rendering index of the WLED compared with monochromatic QDs.