bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Determinant Factors of The Dynamics of Agribusiness Behavior of the Mango Farmers in Greged Sub District, Cirebon District
Authors: Rasmikayati E , Mukti G W , Saefudin B R 
Published: October 2019

Abstract
Cirebon has already been known as one of the mango-producing areas. However, until now, mango agribusiness in the area has not been able to maintain the quality and guarantee the availability of mangoes throughout the year. The problem was caused by the dynamic behavior of the farmers. This indicated that the development of mango agribusiness in the era of globalization should be based on the improvement of agribusiness behavior of mango farmers. The purpose of this paper was to analyze the factors that determine the improvement of agribusiness behavior of mango farmers. The research method employed in this research was survey technique in Greged district of Cirebon regency using simple random sampling technique involving 130 mango farmers. Data were analyzed using path analysis. The results of the study showed that the most powerful factors in improving agribusiness behavior of mango farmers were resource factor (9.2%), institutional factor (8.2%), cultural factor (7%) and technological factor (4.8%). This indicated that the development of sustainable mango agribusiness model in Greged district of Cirebon Regency should be focused on optimizing its resources, increasing its institutional role, preserving the mango cultivation of its farmers and increasing the role of the use of mango farming technology.
Research on applications of phase change materials in solar cell thermal control
Authors: Yang Y H , He Y T , Xiao L X 
Published: October 2019

Abstract
In order to grasp the characteristics of phase change material (PCM) in solar cell thermal control, a two-dimensional thermal control structure model of PV/PCM solar cell thermal control system was established, and study was conducted on influence of PCM phase change temperature, thermal conductivity, latent heat value, etc. on the temperature control characteristics of solar cells. The results show that PCM phase change temperature, thermal conductivity, latent heat value will affect solar cell temperature control characteristics in varying degrees. At the same time, thermal control characteristics of PCM are greatly affected by environmental meteorological conditions (solar irradiance, ambient temperature). The research results provide a reference for optimization design of PV/PCM solar cell thermal control system.
Outlier detection for on-line monitoring data of transformer based on wavelet transform and weighted LOF
Authors: Qin J F , Yang Y , Du H Y , Hong Z J 
Published: October 2019

Abstract
Power transformers are one of the core equipment in the power grid, so it is of great significance to guarantee transformers’ normal operation. By analyzing the dissolved gas content in transformer oil, we can monitor the operation of the power transformer. However, usually there are outliers in the data generated using the on-line monitoring system. In this paper, we propose a new outlier detection method based on wavelet transform and local outlier factor (LOF) algorithm. Using wavelet transform, we get the high dimensional representation of the original data in frequency domain, and by adding the weighted LOF (WLOF), we can identify outliers in high dimensional data set. Furthermore, we use the sliding window method to improve the efficiency of the algorithm, and achieve transformer oil on-line outlier detection efficiently. The experimental results on transformer data from several power transformers indicate that this algorithm can identify the outliers that exceed the threshold value, as well as the oscillations due to fluctuations in gas content. This can help achieve initial diagnosis of transformer oil on-line monitoring system rapidly.
CD177 Enhances the Detection of Myelodysplastic Syndrome by Flow Cytometry
Authors: Alayed Khaled , Meyerson Jeremy B , Osei Ebenezer S , Blidaru Georgeta , Schlegelmilch June , Johnson Michael , Meyerson Howard J 
Published: October 2019

Abstract

Objectives
Previously we demonstrated that a decreased percentage of CD177-positive granulocytes detected by flow cytometry (FCM) was associated with myelodysplastic syndrome (MDS). Here we expand on those findings to more rigorously evaluate the utility of CD177 for the detection of MDS.

Methods
Two hundred patient samples (100 MDS and 100 controls) were evaluated for granulocyte expression of CD177 and 11 other flow cytometric parameters known to be associated with MDS.

Results
We show that CD177, as a single analyte, is highly correlated with MDS with a receiver operating characteristic area under curve value of 0.8. CD177 expression below 30% demonstrated a sensitivity of 51% and a specificity of 94% for detecting MDS with a positive predictive value of 89.5%. In multivariate analysis of 12 MDS-associated FCM metrics, CD177 and the Ogata parameters were significant indicators of MDS, and CD177 increased sensitivity of the Ogata score by 16% (63%-79%) for predicting MDS. Finally, diagnostic criteria incorporating these parameters with a 1% blast cutoff level and CD177 resulted in a sensitivity of 90% and specificity of 91% for detecting MDS.

Conclusions
The findings indicate CD177 is a useful FCM marker for MDS.
Anaesthesia with diethyl ether impairs jasmonate signalling in the carnivorous plant Venus flytrap (Dionaea muscipula)
Authors: Pavlovič Andrej , Libiaková Michaela , Bokor Boris , Jakšová Jana , Petřík Ivan , Novák Ondřej , Baluška František 
Published: October 2019

Abstract

Background and Aims
General anaesthetics are compounds that induce loss of responsiveness to environmental stimuli in animals and humans. The primary site of action of general anaesthetics is the nervous system, where anaesthetics inhibit neuronal transmission. Although plants do not have neurons, they generate electrical signals in response to biotic and abiotic stresses. Here, we investigated the effect of the general volatile anaesthetic diethyl ether on the ability to sense potential prey or herbivore attacks in the carnivorous plant Venus flytrap (Dionaea muscipula).

Methods
We monitored trap movement, electrical signalling, phytohormone accumulation and gene expression in response to the mechanical stimulation of trigger hairs and wounding under diethyl ether treatment.

Key Results
Diethyl ether completely inhibited the generation of action potentials and trap closing reactions, which were easily and rapidly restored when the anaesthetic was removed. Diethyl ether also inhibited the later response: jasmonic acid (JA) accumulation and expression of JA-responsive genes (cysteine protease dionain and type I chitinase). However, external application of JA bypassed the inhibited action potentials and restored gene expression under diethyl ether anaesthesia, indicating that downstream reactions from JA are not inhibited.

Conclusions
The Venus flytrap cannot sense prey or a herbivore attack under diethyl ether treatment caused by inhibited action potentials, and the JA signalling pathway as a consequence.
Consistency for the tree bootstrap in respondent-driven sampling
Authors: Green A K B , McCormick T H , Raftery A E 
Published: October 2019

Summary
Respondent-driven sampling is an approach for estimating features of populations that are difficult to access using standard survey tools, e.g., the fraction of injection drug users who are HIV positive. Baraff et al. (2016) introduced an approach to estimating uncertainty in population proportion estimates from respondent-driven sampling using the tree bootstrap method. In this paper we establish the consistency of this tree bootstrap approach in the case of $m$-trees.
Children in Care: Exploitation, Offending and the Denial of Victimhood in a Prosecution-led Culture of Practice
Authors: Shaw Julie , Greenhow Sarah 
Published: October 2019

Abstract
The following article reports upon recent research, which explored the perceptions of professionals of the issues that affect the sexual and criminal exploitation of children in care, along with a discussion of the effectiveness of current responses to these issues and the challenges that professionals face. The study utilised focus groups and semi-structured interviews to gain the perspectives of thirty-six participants from across a range of agencies involved in children’s social work and youth justice from an area in the north-west of England. The findings echoed previous research by suggesting that for a number of reasons connected to their ‘looked-after’ status and deficiencies within the care system, children are particularly vulnerable to exploitation. Although attempts are being made to develop co-ordinated responses to safeguarding, there is still a long way to go in terms of focusing on vulnerability instead of a prosecution-led approach when offending occurs as a result of exploitation. It is argued how in order to ensure that good, innovative practice becomes ‘standard’ practice; further legislation is required in tandem with a greater degree of education surrounding exploitation and the dynamics inherent in these offences.
Impact of Hormonal Contraceptives on Cervical T-helper 17 Phenotype and Function in Adolescents: Results from a Randomized, Crossover Study Comparing Long-acting Injectable Norethisterone Oenanthate (NET-EN), Combined Oral Contraceptive Pills, and Combined Contraceptive Vaginal Rings
Authors: Konstantinus Iyaloo N , Balle Christina , Jaumdally Shameem Z , Galmieldien Hoyam , Pidwell Tanya , Masson Lindi , Tanko Ramla F , Happel Anna-Ursula , Sinkala Musalula , Myer Landon , Bosinger Steven E , Gill Katherine , Bekker Linda-Gail , Jaspan Heather B , Passmore Jo-Ann S 
Published: October 2019

Abstract

Background
Adolescents in sub-Saharan Africa are at risk for human immunodeficiency virus (HIV) infection and unintended pregnancies. Observational studies suggest that injectable hormonal contraceptives (HCs) increase the HIV risk, although their effects on genital inflammation, particularly HIV-susceptible T-helper 17 (Th17) cells, are unknown. In a randomized crossover study, the effect of injectable norethisterone oenanthate (NET-EN), combined contraceptive vaginal rings (CCVR; NuvaRing), and combined oral contraceptive pills (COCPs) on cervical Th17 cells and cytokines were compared.

Methods
Adolescents (n = 130; 15–19 years) were randomly assigned 1:1:1 to NET-EN, CCVR, or COCPs for 16 weeks, then subsequently crossed over to another HC for 16 weeks. Estrogen, follicular stimulating hormone (FSH), and luteinizing hormone (LH) levels were measured. Chemokine receptor 5 (CCR5), human leukocyte antigen (HLA) DR isotope, and cluster of differentiation 38 (CD38) expression by cervical cytobrush-derived CD4+ T cells was assessed by fluorescence-activated cell sorting. Th17 cells were defined as CCR6+ and CCR10-. Cervicovaginal Th17-related cytokines were measured by Luminex.

Results
CCVR use for the first 16 weeks was associated with reduced Th17 frequencies and lower FSH and LH concentrations, as compared to NET-EN and COCPs, with FSH concentrations and Th17 frequencies correlating significantly. However, Th17-related cytokine concentrations (interleukin [IL]-21, IL-1β, tumor necrosis factor–α, interferon-γ) and CCR5, HLA-DR, CD38, and Th17 frequencies were significantly higher in CCVR than NET-EN and COCP. At crossover, CCVR users changing to COCPs or NET-EN did not resolve activation or cytokines, although switching from COCP to CCVRs increased cytokine concentrations.

Conclusions
CCVR use altered endogenous hormone levels and associated cervical Th17 cell frequencies to a greater extent than use of NET-EN or COCPs, although Th17 cells were more activated and Th17-related cytokine concentrations were elevated. While CCVRs may impact the HIV risk by regulating Th17 numbers, increased activation and inflammation may balance any risk gains.
A Content-Based Model for Tag Recommendation in Software Information Sites
Authors: Gharibi Reza , Safdel Atefeh , Fakhrahmad Seyed Mostafa , Sadreddini Mohammad Hadi 
Published: October 2019

Abstract
Developers use software information sites such as Stack Overflow to get and give information on various subjects. These sites allow developers to label content with tags as a short description. Tags, then, are used to describe, categorize and search the posted content. However, tags might be noisy, and postings may become poorly categorized since people tag a posting based on their knowledge of its content and other existing tags. To keep the content well organized, tag recommendation systems can help users by suggesting appropriate tags for their posted content. In this paper, we propose a tag recommendation scheme that uses the textual content of already tagged postings to recommend suitable tags for newly posted content. Our approach combines multi-label classification and textual similarity techniques to improve the performance of tag recommendation. We evaluate the performance of the proposed scheme on 11 software information sites from the Stack Exchange network. The results show a significant improvement over TagCombine, TagMulRec and FastTagRec, which are well-known tag recommendation systems. On average, the proposed model outperforms TagCombine, TagMulRec and FastTagRec by 26.2, 15.9 and 13.8% in terms of Recall@5 and by 16.9, 12.4 and 9.4% in terms of Recall@10, respectively.
Reading and Theory of Mind in Adolescents with Cochlear Implant
Authors: Figueroa Mario , Darbra Sònia , Silvestre Núria 
Published: October 2019

Abstract
Previous research has shown a possible link between reading comprehension and theory of mind (ToM), but these findings are unclear in adolescents with cochlear implants (CI). In the present study, reading comprehension and ToM were assessed in adolescents with CI and the relation between both skills was also studied. Two sessions were performed on two groups of adolescents aged between 12 and 16 years of age (36 adolescents with CI and 54 participants with typical hearing, TH). They were evaluated by means of a standardized reading battery, a false belief task, and Faux Pas stories. The results indicated that reading and cognitive ToM were more developed in the TH group than in adolescents with CI. However, early-CI and binaural group performance were close to the TH group in narrative and expository comprehension and cognitive ToM. The results also indicated that cognitive ToM and reading comprehension appear to be related in deaf adolescents.
Nuclear magnetic resonance investigation of water transport through the plasma membrane of various yeast species
Authors: Šoltésová Mária , Elicharová Hana , Srb Pavel , Růžička Michal , Janisova Larisa , Sychrová Hana , Lang Jan 
Published: October 2019

ABSTRACT
A specific technique of nuclear magnetic resonance (NMR) spectroscopy, filter-exchange spectroscopy (FEXSY), was employed to investigate water transport through the plasma membrane in intact yeast cells. This technique allows water transport to be monitored directly, thus avoiding the necessity to subject the cells to any rapid change in the external conditions, e.g. osmotic shock. We established a sample preparation protocol, a data analysis procedure and verified the applicability of FEXSY experiments. We recorded the exchange rates in the temperature range 10–40°C for Saccharomyces cerevisiae. The resulting activation energy of 29 kJ mol−1 supports the hypothesis that water exchange is facilitated by water channels—aquaporins. Furthermore, we measured for the first time water exchange rates in three other phylogenetically unrelated yeast species (Schizosaccharomyces pombe, Candida albicans and Zygosaccharomyces rouxii) and observed remarkably different water exchange rates between these species. Findings of our work contribute to a better understanding of as fundamental a cell process as the control of water transport through the plasma membrane.
Insights into wild-type dynamin 2 and the consequences of DNM2 mutations from transgenic zebrafish
Authors: Zhao Mo , Smith Lindsay , Volpatti Jonathan , Fabian Lacramioara , Dowling James J 
Published: October 2019

Abstract
Dynamin 2 (DNM2) encodes a ubiquitously expressed large GTPase with membrane fission capabilities that participates in the endocytosis of clathrin-coated vesicles. Heterozygous mutations in DNM2 are associated with two distinct neuromuscular disorders, Charcot–Marie–Tooth disease (CMT) and autosomal dominant centronuclear myopathy (CNM). Despite extensive investigations in cell culture, the role of dynamin 2 in normal muscle development is poorly understood and the consequences of DNM2 mutations at the molecular level in vivo are not known. To address these gaps in knowledge, we developed transgenic zebrafish expressing either wild-type dynamin 2 or dynamin 2 with either a CNM or CMT mutation. Taking advantage of the live imaging capabilities of the zebrafish embryo, we establish the localization of wild-type and mutant dynamin 2 in vivo, showing for the first time distinctive dynamin 2 subcellular compartments. Additionally, we demonstrate that CNM-related DNM2 mutations are associated with protein mislocalization and aggregation. Lastly, we define core phenotypes associated with our transgenic mutant fish, including impaired motor function and altered muscle ultrastructure, making them the ideal platform for drug screening. Overall, using the power of the zebrafish, we establish novel insights into dynamin 2 localization and dynamics and provide the necessary groundwork for future studies examining dynamin 2 pathomechanisms and therapy development.
Splicing factor DHX15 affects tp53 and mdm2 expression via alternate splicing and promoter usage
Authors: McElderry John , Carrington Blake , Bishop Kevin , Kim Erika , Pei Wuhong , Chen Zelin , Ramanagoudr-Bhojappa Ramanagouda , Prakash Anupam , Burgess Shawn M , Liu P Paul , Sood Raman 
Published: October 2019

AbstractDHX15, a DEAH box containing RNA helicase, is a splicing factor required for the last step of splicing. Recent studies identified a recurrent mutational hotspot, R222G, in DHX15 in ∼ 6% of acute myeloid leukemia (AML) patients that carry the fusion protein RUNX1-RUNX1T1 produced by t (8;21) (q22;q22). Studies using yeast mutants showed that substitution of G for the residue equivalent to R222 leads to loss of its helicase function, suggesting that it is a loss-of-function mutation. To elucidate the role of DHX15 during development, we established the first vertebrate knockout model with CRISPR/Cas9 in zebrafish. Our data showed that dhx15 expression is enriched in the brain, eyes, pectoral fin primordia, liver and intestinal bulb during embryonic development. Dhx15 deficiency leads to pleiotropic morphological phenotypes in homozygous mutant embryos starting at 3 days post fertilization (dpf) that result in lethality by 7 dpf, revealing an essential role during embryonic development. RNA-seq analysis suggested important roles of Dhx15 in chromatin and nucleosome assembly and regulation of the Mdm2-p53 pathway. Interestingly, exons corresponding to the alternate transcriptional start sites for tp53 and mdm2 were preferentially expressed in the mutant embryos, leading to significant upregulation of their alternate isoforms, Δ113p53 (orthologous to Δ133p53 isoform in human) and mdm2-P2 (isoform using distal promoter P2), respectively. We speculate that these alterations in the Mdm2-p53 pathway contribute to the development of AML in patients with t(8;21) and somatically mutated DHX15.
Pharmacokinetics and Pharmacodynamics of Linezolid in Patients With Sepsis Receiving Continuous Venovenous Hemofiltration and Extended Daily Hemofiltration
Authors: Zheng Junbo , Sun Zhidan , Sun Lei , Zhang Xing , Hou Guiying , Han Qiuyuan , Li Xianghui , Liu Gaofeng , Gao Yang , Ye Ming , Wang Hongliang , Yu Kaijiang 
Published: October 2019

Abstract

Background
This prospective study compared pharmacokinetics (PK) and pharmacodynamics (PD) of linezolid in patients with sepsis receiving continuous venovenous hemofiltration (CVVH) with patients receiving extended daily hemofiltration (EDH).

Methods
Patients with sepsis treated with linezolid and CVVH or EDH were included. Serial blood samples were collected and linezolid concentrations measured. PKs were analyzed using Pmetrics. Monte Carlo simulations were used to evaluate PD target achievement.

Results
From 20 patients, 320 blood samples were collected for PK and PD analysis. PK profiles of linezolid were best described by a 2-compartment model. PK parameters were not significantly different between EDH and CVVH groups and were associated with body weight, renal replacement therapy (RRT) duration, and sequential organ failure assessment score. Monte Carlo simulations showed poor fractional target attainment for a minimum inhibitory concentration (MIC) of 2 mg/L with standard 600 mg intravenous administration every 12 hours.

Conclusions
Patients with sepsis receiving RRT exhibited variability in PK/PD parameters for linezolid. PK parameters were not significantly different between CVVH- and EDH-treated patients. Higher probability of target attainment would be achievable at a MIC of 2 mg/L in EDH patients. Higher linezolid doses should be considered for patients on RRT to achieve adequate blood levels.
‘Onward to the End of the Nineteenth Century’: Edward Prime-Stevenson’s Queer Musicological Nostalgia
Authors: Franseen Kristin M 
Published: October 2019

Abstract
Relatively little known today, Edward Prime-Stevenson (1858–1942) was a man of hidden depths. Despite success as a music critic, Prime-Stevenson left the United States around the turn of the century to pursue (in his words) ‘studies in a branch of sexual psychology’ in Europe. Following this move, he published two books on homosexuality under the pseudonym Xavier Mayne. While ‘Mayne’s’ work has been analysed in depth by LGBTQ+ literary scholars in the past twenty years, Prime-Stevenson’s musical writings have received substantially less attention. This article considers the intertextual relationships between his musical and sexological writings—in particular, his approach to secret messages in instrumental music, musings on musical intimacy, and attempts at queer canon-building—as both a scholarly attempt at creating a proto-‘queer musicology’ through sheer force of will and a deeply personal voicing of queer musical nostalgia.
Diverse outcomes of planet formation and composition around low-mass stars and brown dwarfs
Authors: Miguel Y , Cridland A , Ormel C W , Fortney J J , Ida S 
Published: October 2019

Abstract
The detection of Earth-size exoplanets around low-mass stars –in stars such as Proxima Centauri and TRAPPIST-1– provide an exceptional chance to improve our understanding of the formation of planets around M stars and brown dwarfs. We explore the formation of such planets with a population synthesis code based on a planetesimal-driven model previously used to study the formation of the Jovian satellites. Because the discs have low mass and the stars are cool, the formation is an inefficient process that happens at short periods, generating compact planetary systems. Planets can be trapped in resonances and we follow the evolution of the planets after the gas has dissipated and they undergo orbit crossings and possible mergers. We find that formation of planets above Mars mass and in the planetesimal accretion scenario, is only possible around stars with masses M⋆ ≥ 0.07Msun and discs of Mdisc ≥ 10−2 Msun. We find that planets above Earth-mass form around stars with masses larger than 0.15 Msun, while planets larger than 5 M⊕ do not form in our model, even not under the most optimal conditions (massive disc), showing that planets such as GJ 3512b form with another, more efficient mechanism. Our results show that the majority of planets form with a significant water fraction; that most of our synthetic planetary systems have 1, 2 or 3 planets, but planets with 4,5,6 and 7 planets are also common, confirming that compact planetary systems with many planets should be a relatively common outcome of planet formation around small stars.