bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral squamous cell carcinoma resection and neck dissection mortality: a 10‐year national audit study
Authors: Ong Yi Long Roy , Sambrook Paul , Maddern Guy 
Published: November 2020

AbstractBackgroundOral squamous cell carcinoma (OSCC) is a significant public health issue. Australia had 448 deaths from lip and oral cavity cancer in 2018, some of which could be prevented. Consideration of the factors contributing to mortality after OSCC resection can provide a greater insight into how deaths can be prevented.MethodsThis paper used data from the Australia and New Zealand Audit of Surgical Mortality from the last 10 years from 1 January 2009 to 31 December 2018 for analysis. All surgical deaths were captured as the treating surgeons were mandated to complete a surgical case form for assessment by an independent surgeon from the same specialty.ResultsThis study found 25 cases of death after OSCC resection. In 44% of cases, death was related to cardiac causes and 40% was related to respiratory causes. Fourteen cases were found to have issues with management, and 25 issues were raised. In 36% of issues, it was found to be related to decision to operate. There were no obvious differences between the patients who had neck dissections and those who did not.ConclusionThe decision to operate on high‐risk patients, cardiovascular and respiratory causes were the major contributors to surgical mortality. The small number of deaths and the limitation of using existing data limited statistical analysis and conclusions. Changes could be made to the Australia and New Zealand Audit of Surgical Mortality to improve the results for analysis.
The incidence of transient infantile pseudohypoaldosteronism in Ireland: A prospective study
Authors: Kaninde Abhidhamma , Grace Mariana L. , Joyce Caroline , Taylor Norman F. , Ghataore Lea , Riordan Micheal F. , O’Grady Michael J. , O’Connell Susan M. 
Published: November 2020

AbstractAimTo review the clinical course, outcome and incidence of infantile salt wasting associated with urinary tract infection (UTI) and/or urinary tract malformation (UTM) over a two‐year surveillance period on the island of Ireland.MethodsA two‐year (2013‐14) prospective surveillance undertaken via the Irish and Ulster Paediatric Surveillance Units. Monthly prepaid postcards were circulated to consultant paediatricians (n = 260) at all paediatric units on the island of Ireland. Infants under one year of age presenting for the first time with hyponatraemia (Na < 130 mmol/L) and/or hyperkalaemia (K > 5.0 mmol/L) associated with urosepsis/UTM were reported.ResultsAll 7 reported patients (6 male) had culture‐proven UTI, and 5 (71%) also had an underlying UTM (one diagnosed antenatally). Four (57%) patients had a documented elevated serum aldosterone supporting secondary pseudohypoaldosteronism (PHA) as the underlying diagnosis. Data on aldosterone were not reported in the other 3 patients, but clinical features were suggestive of secondary PHA. The estimated incidence for the Irish population of transient PHA is 1 per 13,200 total live births per year.ConclusionsSalt wasting is a rare complication of UTI, especially if associated with underlying UTM. Boys appear to be at particular risk.
Pharmacokinetics and safety of evogliptin in hepatically impaired patients
Authors: Hong Taegon , Jin Byung Hak , Kim Choon Ok , Yoo Byung Won , Kim Dasohm , Lee Jung Il , Kim Beom Kyung , Ahn Sang Hoon , Kim Do Young , Park Jun Yong , Park Min Soo 
Published: November 2020

AimsEvogliptin is a potent and selective dipeptidyl peptidase‐4 inhibitor for glycaemic control in patients with type 2 diabetes mellitus. Since evogliptin is mainly eliminated through hepatic metabolism, we investigated the pharmacokinetics (PKs) and safety characteristics of evogliptin in Korean patients with mild or moderate hepatic impairment.MethodsAn open‐label, parallel‐group study was conducted in patients with mild or moderate hepatic impairment and healthy control subjects matched to each patient for sex, age and body mass index. A single dose (5 mg) of evogliptin was administered orally, and serial blood samples were collected over 120 h to assess the PK profile of evogliptin and its main metabolites (M7 and M8).ResultsPatients with mild hepatic impairment and their matched healthy controls showed similar maximum concentration (Cmax) and area under the concentration–time curve values from 0 to 120 h (AUClast); the geometric mean ratio (GMR) and 90% confidence interval (CI) were 1.04 (0.80, 1.35) and 1.01 (0.90, 1.14), respectively. Exposure to evogliptin (Cmax and AUClast) was increased by about 40% in patients with moderate hepatic impairment—the GMR and 90% CI were 1.37 (1.09, 1.72) and 1.44 (1.18, 1.75), respectively. The metabolic ratios of M7 and M8 were lower in patients with moderate hepatic impairment than in matched healthy controls. Evogliptin was well tolerated by both patients and healthy subjects.ConclusionAlthough evogliptin exposure was increased in patients with moderate hepatic impairment, the increase is unlikely to affect safety and efficacy adversely, and no dose adjustment is warranted.
Tachyplesin induces apoptosis in non‐small cell lung cancer cells and enhances the chemosensitivity of A549/DDP cells to cisplatin by activating Fas and necroptosis pathway
Authors: Wu Jun , Chen Xi , Zhang Jiaxi , Chen Jianming , Wang Yajun , Wei Ting , Ma Jinyao , Li Yuanqi , Mo Ting , He Zhan , Zhang Haitao 
Published: November 2020

AbstractCisplatin has strong broad‐spectrum anticancer activity and is one of the most effective anticancer drugs currently used. The clinical application of cisplatin has led to the resistance of cancer cells to cisplatin. Tachyplesin is an active, natural marine peptide with antitumour activity. In the present study, we investigated whether tachyplesin can be used in non‐small cell lung cancer (NSCLC) A549 and H460 cells as well as the cisplatin‐resistant human A549/DDP NSCLC cell line. The results revealed that tachyplesin treatment significantly inhibited proliferation and induced apoptosis in A549 and H460 cells and the combination of tachyplesin and cisplatin significantly suppressed migration and improved sensitivity to cisplatin in A549/DDP cells. Further mechanistic examination revealed that tachyplesin induced apoptosis in A549/DDP cells by increasing Fas, FasL and p‐RIPK1 levels. These results indicated that tachyplesin induces lung cancer death by activating the Fas, mitochondrial and necroptosis pathways. Tachyplesin could be developed as a candidate drug for cisplatin‐resistant NSCLC.
‘Discuss it with your legal guardian’: Challenges in practising care for young unaccompanied refugee minors
Authors: Omland Guro Brokke , Andenas Agnes , Sveaass Nora 
Published: November 2020

AbstractHow is care arranged for unaccompanied refugee minors at residential care institutions, and what kind of conditions do these arrangements constitute for young persons' well‐being and development? Informed by developmental perspectives that consider young people's development through participation across contexts in everyday life and by research into how parents in ‘ordinary’ families organize care, we developed a study based on interviews with 15 unaccompanied refugee minors and their professional caregivers at residential care institutions. The interviews were analysed systematically by exploring how care is arranged between professionals and its implications in the young persons' lives. The results elucidate how responsibility for following up and making sense of central issues in the lives of the minors was allocated to professionals outside the daily care rather than being part of the primary caregivers' contact with the minors. This practice contrasts with what young persons in ‘ordinary families’ in Norway enjoy, where coordination across contexts and keeping an overview of the total care are considered the responsibility of parents. The article focuses on the outsourcing of what we call refugee‐related legal issues in the minors' everyday lives, to the legal guardians, which appeared to be a barrier to being understood and supported.
Determining the role of eudaimonic values in conservation behavior
Authors: Winkler‐Schor Sophia , van Riper Carena J. , Landon Adam , Keller Rose 
Published: November 2020

AbstractValues are the fundamental reasons why people engage in conservation behaviors. Recent research has called for a more refined approach to studying values in a way that accounts for the concept of eudaimonia. However, the empirical properties for a eudaimonic value scale have not been tested given that previous investigations have remained at the theoretical level. Drawing from an on‐site survey of visitors to Denali National Park and Preserve, Alaska, we used a latent profile analysis to better understand the expression of multiple values of nature. Specifically, we segmented respondents by their value orientations with a particular focus on evaluating eudaimonic and hedonic values, alongside the established dimensions of altruistic, biospheric, and egoistic values. We identified 4 distinct subgroups defined by value orientations and validated these subgroups based on measures of conservation behavior and sociodemographic characteristics (e.g., age). These results indicated campaign messaging should harness a combination of eudaimonic, biospheric, and altruistic values to propel individual behavior. We also observed that hedonic and egoistic values defined how people related to nature and played a role, albeit less pronounced, in motivating them to take action. Our study is one of the first efforts to operationalize eudaimonia in a conservation context; thus, we have opened a new avenue for protected‐area managers to align their strategies with the underlying values of stakeholders.
Tools for assessing the psychometric adequacy of latent variables in conservation research
Authors: Kyle Gerard , Landon Adam , Vaske Jerry , Wallen Kenneth 
Published: November 2020

AbstractConservation psychology has a history of measuring variables that cannot be seen (e.g., values, attitudes, norms). Such latent variables are critical drivers of human action and are often measured using responses to survey questions. Tools for establishing the psychometric adequacy of unobservable, latent variables has been a century‐long pursuit and challenge for quantitative psychologists and statisticians. Fundamental questions at the heart of this challenge include is what is claimed to be measured (validity) being measured and is measurement consistent (reliability)? We examined common methods used to establish the validity and reliability of psychometric instruments. Through a case study of anglers in Texas, we investigated the protocols and metrics used to evaluate the measurement of latent variables. The indicators we tested (identity, awareness of consequences, ascription of responsibility, and personal norms) validly and reliably assessed latent variables. Our findings also illustrated decision protocols (e.g., discriminant validity, convergent validity, internal consistency) involved in assessing the psychometric adequacy of latent variable indicators. The ability to correctly identify significant relationships among unobserved variables and their influence on human action is directly tied to the adequacy of measurement. In an era of instability and change that threatens social‐ecological systems worldwide, the need for accuracy and precision in conservation social science has never been greater. Research that employs flawed measures has potential to lead to erroneous conclusions and undermine conservation and biodiversity protection.
Does oncological outcome differ between restorative and nonrestorative low anterior resection in patients with primary rectal cancer?
Authors: Roodbeen Sapho X. , Blok Robin D. , Borstlap Wernard A. , Bemelman Willem A. , Hompes Roel , Tanis Pieter J. ,   the Dutch Snapshot Research Group
Published: November 2020

AbstractAimNonrestorative low anterior resection (n‐rLAR) (also known as low Hartmann’s) is performed for rectal cancer when a poor functional outcome is anticipated or there have been problems when constructing the anastomosis. Compared with restorative LAR (rLAR), little oncological outcome data are available for n‐rLAR. The aim of this study was to compare oncological outcomes between rLAR and n‐rLAR for primary rectal cancer.MethodThis was a nationwide cross‐sectional comparative study including all elective sphincter‐saving LAR procedures for nonmetastatic primary rectal cancer performed in 2011 in 71 Dutch hospitals. Oncological outcomes of patients undergoing rLAR and n‐rLAR were collected in 2015; the data were evaluated using Kaplan–Meier survival analysis and the results compared using log‐rank testing. Uni‐ and multivariable Cox regression analysis was used to evaluate the association between the type of LAR and oncological outcome measures.ResultsA total of 1197 patients were analysed, of whom 892 (75%) underwent rLAR and 305 (25%) underwent n‐rLAR. The 3‐year local recurrence (LR) rate was 3% after rLAR and 8% after n‐rLAR (P < 0.001). The 3‐year disease‐free survival and overall survival rates were 77% (rLAR) vs 62% (n‐rLAR) (P < 0.001) and 90% (rLAR) vs 75% (n‐rLAR) (P < 0.001), respectively. In multivariable Cox analysis, n‐rLAR was independently associated with a higher risk of LR (OR = 2.95) and worse overall survival (OR = 1.72).ConclusionThis nationwide study revealed that n‐rLAR for rectal cancer was associated with poorer oncological outcome than r‐LAR. This is probably a noncausal relationship, and might reflect technical difficulties during low pelvic dissection in a subset of those patients, with oncological implications.
Diagnostic yield and treatment impact of whole‐genome sequencing in paediatric neurological disorders
Authors: Lee Hsiu‐Fen , Chi Ching‐Shiang , Tsai Chi‐Ren 
Published: November 2020

AimTo investigate the diagnostic yield and treatment impact of whole‐genome sequencing (WGS) in patients with paediatric neurological disorders.MethodFrom January 2016 to December 2019, paediatric patients who had suspected genetic neurological disorders were assessed using WGS. The phenotypes of eligible patients were divided into four groups: patients with neurodevelopmental disorders; patients with epilepsy; patients with neuromuscular disorders; and patients with movement disorders.ResultsA total of 214 consecutive patients (128 males, 86 females) underwent WGS. The mean (SD) age of disease onset was 13.8 (27.6) months (range 1d–15y 5mo). The mean (SD) age at which WGS was performed was 71.7 (58.9) months (range 8d–18y). A molecular diagnosis was reported in 43.9% of patients. The highest diagnostic rate was achieved in 62.5% of patients with neuromuscular disorders, 47.5% of patients with epilepsy, 41.1% of patients with neurodevelopment disorders, and 15.4% of patients with movement disorders. All 94 patients with a WGS diagnosis were given access to genetic counselling and 23.4% of patients had immediate changes in treatment strategies after undergoing WGS.InterpretationWGS allows paediatric neurologists to integrate genomic data into their diagnosis and adjust management strategies for a range of clinical and genetically heterogeneous disease entities to improve the clinical outcomes of patients. In our cohort, the diagnosis of a significant proportion of patients was reached through WGS (43.9%). Clinicians could use these results to directly guide the management of their patients and improve their clinical outcomes (23.4%).
What this paper adds

For selected children in our cohort, the diagnostic yield of whole‐genome sequencing (WGS) was 43.9%.

WGS can be used to expand our knowledge of phenotype–genotype variations.
Collusion among Accounting Students: Data Visualization and Topic Modeling of Student Interviews
Authors: Shrader Charles B. , Ravenscroft Sue Pickard , Kaufmann Jeffrey B. , Hansen Kyle 
Published: November 2020

ABSTRACTAlthough classroom cheating violates academic standards of behavior, it occurs frequently. Although the research on cheating is extensive, few researchers have interviewed students directly involved in cheating behaviors. We explore interview responses gathered from a cohort of graduate accounting students, some of whom colluded on an assignment, whereas others did not. We use Latent Dirichlet Allocation (LDA), a powerful text mining algorithm, as our primary tool to explore the underlying topical structure of the interviews and to demarcate subtle differences among students’ reactions to and explanations of their experience. Because LDA does not impose or require a priori theories, we use it to provide ideas for future research rather than to test extant theories about classroom collusion. We identify five primary topics that emerged from the accounting students’ reflections: (1) general course context (including honor code), (2) the rigor of the assignment, (3) student teams as support mechanisms, (4) the perceived repercussions of cheating (colluding), and (5) personality differences between the tax and audit track students. We find subtle language differences between colluders and noncolluders. Colluders considered the nature of the assignment and the difference between tax and audit majors more significant than noncolluders did. Additionally, the role of teams and the general institutional context were somewhat less relevant for colluders than for noncolluders. We conclude by exploring ethical and pedagogical implications of structuring courses as heavily team based for teaching and future research purposes.
Lemon and Schinus polygama essential oils enhance male mating success of Anastrepha fraterculus
Authors: Ruiz María J. , Juárez María L. , Jofré Barud Flavia , Goane Lucía , Valladares Gabriela A. , Bachmann Guillermo E. , Belliard Silvina A. , Páez Jerez Paula , Zamora Belli Ana Lucía , García Méndez F. Daniela , Segura Diego F. , López M. Liza , Vera María T. 
Published: November 2020

AbstractThe sterile insect technique (SIT) is an environmentally friendly pest control method that relies on the introduction of sterility into the pest population by the release of sterile males. Many Tephritidae fruit fly pests are currently being controlled with SIT. Sterile insect technique efficacy can be increased if the sexual success of mass‐reared sterile males is enhanced. Phytochemicals influence the sexual behaviour of many species of phytophagous insects. Here, we evaluated the possibility of using essential oils to enhance male sexual success of the highly polyphagous fruit fly pest Anastrepha fraterculus (Wiedemann) (Diptera: Tephritidae), also known as the South American fruit fly. In laboratory tests, we determined the effect of exposing males to volatiles from seven essential oils [Baccharis spartioides (Hook. & Arn) Cabrera (Asteraceae), Schinus polygama (Cav.) Cabrera, Schinus areira (L.) (Anacardiaceae), Zingiber officinale (Roscoe) (Zingiberaceae), Citrus limon (L.) Burm. F., Citrus paradisi Macfad., and Citrus sinensis (L.) Osbeck (Rutaceae)] and two monoterpenes (limonene and citral) that are present at high proportions in some of the oils we evaluated. One exposed and one non‐exposed (control) male were placed in a mating arena with one virgin female. We recorded the type of male chosen as mating partner, copula start time, and copula duration. Laboratory males exposed to the volatiles of C. limon and S. polygama essential oils achieved more matings than non‐exposed males. The rest of the oils had no effect on male mating success. In addition, limonene‐exposed males obtained significantly more matings than non‐exposed males, and citral induced a detrimental effect. Exposure to the volatiles of the various essential oils and monoterpenes did not impact on copula start time and copula duration. We discuss the role of essential‐oil volatiles on A. fraterculus males’ sexual behaviour and its implications for SIT.
Multiple‐scale negative impacts of warming on ecosystem carbon use efficiency across the Tibetan Plateau grasslands
Authors: Chen Ning , Zhang Yangjian , Zhu Juntao , Cong Nan , Zhao Guang , Zu Jiaxing , Wang Zhipeng , Huang Ke , Wang Li , Liu Yaojie , Zheng Zhoutao , Tang Ze , Zhu Yixuan , Zhang Tao , Xu Mingjie , Di Yangping , Chen Yao 
Published: November 2020

AbstractAimEcosystem carbon use efficiency (CUEe) is a core parameter of ecosystem process models, but its relationships with climate are still uncertain, especially for ecosystems with harsh environments. Large inconsistencies in climate impacts on the CUEe have been reported among various spatial scales. The goal of this study was to examine whether warming promotes or restricts the CUEe and whether the CUEe responds to a warming gradient in a linear or nonlinear manner.LocationTibetan Plateau.Time period2000–2018.Major taxa studiedAlpine grassland ecosystem.MethodsWe integrated multiple‐source data of carbon fluxes and CUEe, including warming experiments at a site scale, eddy covariance observations at a landscape scale and synthesized warming experiments and ecosystem process models at a regional scale. Next, we deployed a statistical model to examine the warming impacts on the CUEe across scales; the effects of biotic and abiotic factors on the CUEe and its components were summarized based on the results of standardized major axis tests and routines, structural equation modelling and nonlinear models.ResultsThis study reported a suppressive warming impact on the CUEe, which followed a nonlinear curve with severe inhibition in the high‐level warming treatment. With a warming threshold of 1.5–2.0°C, CUEe response patterns transitioned from no change to a significant decrease. The restriction effects can be ascribed to the joint adverse and asymmetric effects of warming on CUEe components under multiple‐level warming. Warming‐modified relationships among CUEe components and the nonlinear effects of biotic and abiotic factors led to the nonlinear responses of CUEe to warming.Main conclusionsThis study revealed suppressive and nonlinear effects of warming on the CUEe, including especially dramatic CUEe decreases with high‐level warming. These findings are critical for optimizing model parameters and improving predictions of the carbon sequestration capacity of alpine grasslands.