bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-Invasive Diagnostic Strategies for Membranous Nephropathy in the NEPTUNE Study
Authors: Zee Jarcy , Hogan Jonathan J. , Abdullah Ahmed , Liu Lili , Kiryluk Krzysztof , Beck Laurence H. 
Published: February 2025

Background:
Clinical practice guidelines recommend that a kidney biopsy is no longer required to confirm a diagnosis of membranous nephropathy (MN) in patients with nephrotic syndrome and a positive test for anti-phospholipase A2 receptor antibodies (PLA2R-Ab). However, the optimal diagnostic strategy for using the PLA2R-Ab enzyme-linked immunosorbent assay (ELISA), PLA2R-Ab indirect immunofluorescence (IIF) test, and genetic risk score for diagnosing MN, including the tests’ optimal thresholds for positivity among incident patients with proteinuria, is still unknown.

Methods:
We used serum samples at or before the first clinically indicated kidney biopsy from participants in the Nephrotic Syndrome Study Network (NEPTUNE) to analyze test performance characteristics using different combinations and cut-offs of the PLA2R-Ab ELISA, IIF, and genetic risk score for diagnosing MN. Secondary analyses included serum samples within 6 months after biopsy but before any immunosuppression use.

Results:
There were 325 study participants with serum samples available on or before the day of kidney biopsy and an additional 143 study participants with samples within six months after biopsy but before any immunosuppression use. Of these participants, 26% (N=85) had biopsy-confirmed MN. The combination of ELISA ≥2 RU/mL and positive IIF was the optimal approach, with sensitivity of 0.60, specificity of 1.00, negative predictive value of 0.92, and positive predictive value of 1.00. Using IIF to confirm only borderline ELISA titers between 2-20 RU/ml resulted in similar sensitivity but specificity of >0.99. In our multiethnic study sample, we did not find improved diagnostic performance with the addition of genetic risk scores.

Conclusions:
In the NEPTUNE cohort, combined PLA2R-Ab testing with ELISA and IIF provided optimal test characteristics in making a non-invasive diagnosis of MN before or soon after kidney biopsy, including in patients with sub-nephrotic proteinuria. Further studies in multiethnic populations are needed to assess whether genetic data can augment this approach.
The Influence of CHSE on Tourists' Interest in Selecting Star-Rated Hotels Post-COVID-19 Pandemic in Gili Trawangan
Authors: Christie Fleury , Lalu Muhammad Furkan  
Published: February 2025

Pupose: The purpose of this study is to investigate how travelers' interest in selecting star-rated hotels is influenced by cleanliness, health, safety, and environmental sustainability (CHSE) in Gili Trawangan after the COVID-19 pandemic.
Method: Associative research using a quantitative technique is the research design used. A survey using primary data sources that provide quantitative information on the number of domestic and foreign visitors to Gili Trawangan is the approach used to acquire the data. The study's population consists of all visitors to Gili Trawangan, both domestic and foreign. We use 90 samples for this study.
Result: The findings of the data analysis show that the variables related to cleanliness, health, safety, and environmental sustainability all have a positive and significant impact on interest in making a purchase. The variables related to cleanliness, on the other hand, do not significantly affect interest in making a purchase.
Propuesta para una aproximación teórico-metodológica acerca de la construcción social de bienestar-es/malestar-es
Authors: Pagnamento Licia 
Published: February 2025

Este artículo reflexiona sobre la idea de “bienestar-es/malestar-es” recuperando aproximaciones vinculadas a la vertiente socio-antropológica latinoamericana y sumando aportes provenientes del vasto campo de la psicología. Se considera que, en nuestras sociedades occidentales urbanas contemporáneas, lo que solemos llamar salud y nuestra percepción del malestar, forman parte de un proceso de construcción social históricamente situado y condicionado multidimensionalmente. De esta manera, los bienestar-es y malestar-es emergen como parte de fenómenos estructurales asociados a procesos de desigualdad y diferenciación social que dan lugar a condiciones de vida y procesos simbólicos y políticos (relativos al poder) específicos. En este marco, bienestar-es y malestar-es se conjugan sin excluirse en un entramado dinámico de prácticas y sentidos diversos. Además, se considera un acercamiento a los distintos planos o dimensiones de la existencia humana, que suelen identificarse como biofísico, psicológico, emocional y socio-relacional, en un intento por sumar dimensiones insoslayables. Finalmente, el artículo presenta una aproximación a consideraciones conceptuales implicadas en la elaboración de un instrumento de recolección de información (encuesta) que está siendo puesto a prueba (año 2024) en el marco en un proyecto de investigación en curso radicado en el Centro Interdisciplinario de Metodología de las Ciencias Sociales, Universidad Nacional de La Plata.
Barriers and Facilitators of Family Meetings in Primary Palliative Care: Insights From Slovenia
Authors: BAJT Mirjam , JAGODIC KLIPŠTETER Lucija , ZELKO Erika 
Published: February 2025

ABSTRACT

Background
Within palliative care, family meetings are recognised as the most effective practice for placing the patient and their family at the centre of care, thereby ensuring quality palliative care. The aim of this study was to determine how these meetings are conducted in primary healthcare and to identify the factors influencing them.

Methods
Sixteen semi-structured interviews were conducted with family physicians (FP) in Slovenia, who were expressly, and using the snowball method, invited to participate in the study. Transcripts were analysed using the principles of thematic analysis.

Results
It was found that participating FPs frequently discuss diseases, treatment, expectations and goals with patients and families. However, these discussions are seldom structured and fully conducted according to family meeting guidelines, primarily due to time constraints. Barriers to conducting family meetings include patient and family reluctance, the staff’s lack of palliative care knowledge, time, and financial challenges. Positive factors include a good doctor-patient-family relationship, an exact diagnosis, the doctor’s experience and competence, additional palliative care training and the presence of other team members.

Conclusion
Our research provides a unique insight into the implementation of family meetings at the primary level in Slovenia. FPs recognise numerous benefits of family meetings and consider them meaningful and time efficient. They emphasise that open discussions with the patient and their family are crucial for quality palliative care at the primary level. Considering simpler models of family meetings for the primary level appears sensible. Further research is needed to assess the cost-benefit relationship of family meetings.
Sociodemographic Determinants of Health Literacy Among University Students of Health Sciences in Kosovo
Authors: JERLIU Naim , KAMBERI Haxhi , MONE Iris , KRASNIQI Pranvera , BURAZERI Genc 
Published: February 2025

ABSTRACT

Objective
Our objective was to assess the level and sociodemographic correlates of health literacy (HL) among university students of health sciences in Kosovo.

Methods
A cross-sectional study was conducted in Kosovo during February-April 2024, including 470 students of health sciences from the universities of Prishtina and Gjakova (≈86% females; mean age: 20.7±2.7 years; response rate: 70%). The internationally standardised European Health Literacy Survey Questionnaire (HLS-EU-Q) was self-administered, along with information on sociodemographic factors. Binary logistic regression was used to assess the independent sociodemographic correlates of HL.

Results
Only 7% of the students exhibited “inadequate and/or problematic” HL, whereas about 93% of participants displayed “sufficient and/or excellent” HL. In multivariable-adjusted binary logistic regression models, “inadequate and/or problematic” HL was strongly and positively associated with the male gender only (OR=3.6, 95%CI=1.5-8.9).

Conclusions
We evidenced a relatively high general HL level among university students of health sciences in Kosovo, especially among females. Enhancing HL among future health professionals could guide policies that prioritise embedding health education and resources into higher education institutions, potentially improving students’ health behaviours and health outcomes, as a major prerequisite for their future work with patients and communities.
Possibilities of colon ultrasound in determining the severe course and prognosis of recurrent Clostridioides difficile colitis
Authors: Pimanov S. I. , Rutskaya I. A. 
Published: February 2025

Purpose of the study: to determine ultrasound signs of severe course and prognostic criteria for recurrence of Clostridioides difficile (Cl. difficile) colitis and the possibility of separating clinically negligible antibiotic-associated diarrhea from its case related with Clostridial infection. In order to fulfill the aim the study involved patients with and without COVID-19.Material and Methods. A continuous random sample consisted of 253 patients with antibiotic-associated diarrhea. We used standard, recommended by international and Russian agreements methods of the intestinal wall ultrasound examination and diagnostics of SARS-CoV-2 and Cl. difficile infection.Results. It was found that in antibiotic-associated diarrhea widespread intestinal wall thickening greater than 3.2 mm by ultrasonography is observed in Cl. difficile colitis. In case of diarrhea in patients with COVID-19, the detection of intestinal wall thickness of more than 4.0 mm indicates the presence of pseudomembranous colitis when intestinal pathology of ischemic genesis is excluded. Severe course of Сlostridial colitis is characterized by widespread increase in the colonic wall thickness with a maximum value of more than 7.2 mm at echography. Furthermore, there may be additional ultrasound signs of severe course of Cl. difficile colitis: the presence of paracolic free fluid and/or ascitic fluid in various regions of the abdominal cavity; increased echogenicity of adipose tissue adjacent to the inflamed intestine (omentum) and “increase” in its volume; impaired stratification of the colonic wall; thickening of the small intestine wall more than 3.0 mm; paresis of the colon; toxic megacolon. When thickening of the intestinal wall detected by ultrasound in patients with Cl. difficile colitis is more than 6.0 mm after the standard course of treatment with the achievement of clinical target results (absence of diarrhea, normalization of temperature and laboratory parameters) it is a predictor of recurrence of the disease. The described ultrasound diagnostic criteria for pseudomembranous colitis can be used for establishing its severe course and high probability of recurrence in the case of the combination of Cl. difficile colitis with COVID-19.Conclusion: the use of ultrasound examination of the intestinal wall and surrounding structures allows to detail the diagnosis of Cl. difficile colitis.
Integral ultrasound scale for assessing retrobulbar blood flow in type 1 diabetes mellitus at a young age
Authors: Fomina S. V. , Samoilova Iu. G. , Zavadovskaya V. D. , Koshmeleva M. V. , Kachanov D. A. , Trifonova E. I. , Zorkaltsev M. A. , Yun V. Е. 
Published: February 2025

Safe follow-up and assessment of early changes in ocular hemodynamics in young patients with type 1 diabetes mellitus is of paramount importance. Doppler ultrasound is widely used in ophthalmology to assess the blood supply to the eyeball and orbit. The method is accessible, safe, painless, and can be used for dynamic monitoring of changes in the hemodynamics of the eye and orbit in children and adolescents with type 1 diabetes mellitus.Objective: to develop an ultrasound scale for a comprehensive assessment of changes in retrobulbar blood flow in patients with type 1 diabetes mellitus in childhood and adolescence.Materials and methods. The study included data from 223 children aged 7–18 years, 173 children with type 1 diabetes, and a control group – 50 children. The analysis took into account ultrasound indicators in b-mode, Doppler mode, and ophthalmoscopy data.The results obtained from the study report the possibilities of using the Oph-RADS ultrasound scale for a comprehensive assessment of retrobulbar blood flow in patients with type 1 diabetes mellitus at a young age.
Elastography of renal parenchyma in healthy patients (literature review)
Authors: Madzhugin M. L. , Bolotskov A. S. , Firsov M. S. , Dadayan A. R. 
Published: February 2025

Aim: analysis of literature sources and comparative evaluation of research results on the effectiveness of performing renal elastography in almost healthy patients, development of stiffness standards for kidneys in practically healthy patients and development of a standard technology for performing the study.Material and methods. A search was conducted for scientific articles, publications, clinical recommendations, reports of congresses in the information and analytical systems eLibrary, Google Scholar and PubMed for 2013–2024 by keywords: kidney elastography, assessment of kidney stiffness, ultrasound elastography of the kidneys, renal elastography, renal stiffness. The analysis of the literature lists of the found articles according to the relevant criteria was also carried out.Results. According to the relevant keywords, 288 articles were selected, including publications of scientific congresses and conferences, 39 articles were recognized by the authors as corresponding to the subject of the scientific review. And 8 additional articles were selected from the literature lists of the found articles. As a result of the search, a group of articles was created among which the material was analyzed to get answers to the questions posed.Conclusion. The analysis of the literature data is one of the stages of systematization of previously conducted studies in the field of renal elasticity and allows us to note the importance of excluding all factors described by previous authors that cause significant variability in the stiffness of unchanged renal parenchyma. As a result of the review, the authors showed the possibility of using 2D shear wave ultrasound elastography in assessing the stiffness of the renal parenchyma by a non-invasive method and the need to develop a standard research methodology that minimizes the error.
The Relationship of Pre- and Post-Operative Kidney Function and The Degree of Hydronephrosis Caused by Stones and Malignancy in Patients who Have Had A DJ Stent Installed
Authors: Rahman Eka Yudha , Maulani Eka Putri , Yasmina Alfi , Sutapa Hendra , Akbar Izaak Zoelkarnain , Ardansyah Audi , Rudiansyah Mohammad 
Published: February 2025

Aim: This study aims to assess the relationships between ureum, creatinine, GFR and the degree of hydronephrosis, both before and after DJ stent installation. This study also assess the association between ureum, creatinine and GFR before and after the DJ stent placement. Methods: An analytical observational study with a cross-sectional design was conducted. Patients with hydronephrosis caused by urinary stones in RSUD Ulin Banjarmasin during 1 January 2022 until 31 January 2023 were included. Renal function (ureum, creatinine, GFR) and degree of hydronephrosis data were collected. Results: A total of 37 patients were included. Most of them (76,3%) were <60 years old and males (60.5%). There were no significant relationships between ureum, creatinine, and GFR and the degree of hydronephrosis, both before and after DJ stent installation (p> 0.05). There was no significant differences between ureum, creatinine and GFR before and after DJ stent placement. Conclusion: There is no significant relationship between kidney function and the degree of hydronephrosis caused by urinary stones.

Keywords: hydronephrosis, ureum, creatinine, GFR, DJ stent.
Karakteristik Penyakit Pada Tulang Belakang di Bagian Ilmu Bedah Saraf Rumah Sakit Umum Daerah Arifin Achmad Provinsi Riau Periode Januari 2021-Juni 2023
Authors: Wirdayanto Ade , Okta Randa Said Rafly , Lestari Enny , Perel Puteri Sherly Aprilia 
Published: February 2025

Tujuan: Penelitian ini bertujuan untuk mengetahui karakteristik penyakit pada tulang belakang di Bagian Ilmu Bedah Saraf RSUD Arifin Achmad Provinsi Riau periode Januari 2021-Juni 2023. Metode: Penelitian deskriptif retrospektif dengan metode total sampling dan meneliti data sekunder dari rekam medis. Hasil: Terdapat 67 rekam medis pasien dengan penyakit pada tulang belakang di Bagian Ilmu Bedah Saraf RSUD Arifin Achmad dari bulan Januari 2021-Juni 2023 yang memenuhi kriteria inklusi dan eksklusi penelitian. Kelompok usia paling sering mengalami penyakit tulang belakang adalah pasien berusia diatas 60 tahun (20,8%), berjenis kelamin laki-laki (65,6%), dan umumnya tidak bekerja (49,5%). Gejala klinis yang paling sering dirasakan adalah nyeri punggung (37,3%) dan spinal stenosis merupakan diagnosis terbanyak yang ditegakkan (23%). Lokasi lesi umumnya terletak di regio lumbar (41,3%) dan tindakan paling sering diambil adalah laminektomi (58,2%). Kesimpulan: Penyakit tulang belakang paling banyak dialami oleh lansia, jenis kelamin laki-laki, dan tidak bekerja.
Authors: Triana Ni Putu Ayu , Astuti Luh Gede 
Published: February 2025

Fuzzy C-Means (FCM) merupakan algoritma dalam proses klasterisasi data yang memiliki keterbatasan berupa sensitif terhadap parameter yang digunakan sehingga pada beberapa kasus, solusi akhir yang diberikan bukanlah solusi yang optimal. Salah satu parameter yang berpengaruh adalah tingkat ke-Fuzzy-an algoritma. Parameter ini merupakan bilangan real acak yang lebih besar dari 1. Penentuan parameter tersebut disesuaikan dengan data yang digunakan dan dievaluasi dengan syarat mencapai jumlah iterasi minimum untuk konvergen, nilai akhir objektif yang kecil, dan nilai validitas klaster DBI yang mendekati 0. Pada penelitian ini, data penjualan automotif Indonesia mendapatkan parameter tingkat ke-fuzzy-an algoritma yang optimal pada nilai 2 dengan parameter tetap lainnya, seperti jumlah cluster adalah 3, kesalahan terkecil yang diharapkan adalah 0,00001, dan maksimum iterasi adalah 100.
Patriotism in the context of the formation of social competence of the younger generation (using the example of the activities of the supplementary education system)
Authors: Moroz Egor  Vladimirovich , Pervova Irina  Leonidovna 
Published: February 2025

The process of forming civic guidelines for the social competence of the younger generation is analyzed using the example of the activities of the additional education system in St. Petersburg. The practices of forming civic guidelines for the social competence of the younger generation were chosen as the object of this study. The article presents the materials of a study conducted on the basis of the city Center for Patriotic Education and Preventive Work in 2022, during which the practices of civic and patriotic education of students of educational organizations in St. Petersburg were studied in detail. Two components of the process of forming the social competence of the younger generation were identified: the construction of the semantic content of the value of patriotism (the formulations used to describe this value in the documents studied), as well as the forms of representation of this value directly during the educational process (the forms and types of activities in which students are directly involved). In addition, the frequency of mentions of certain semantic categories in the general discourse space of the Center's activities was recorded. The main methods of scientific research are the method of document analysis and the method of semi-structured interviews. To interpret the results, the authors based the research on the theory of social constructionism and the theory of discourse analysis by E. Laclo and S.Mouff. The authors conclude that today the patriotism is the most important civic quality for the formation of social ties in modern Russia. In some cases its significance is so great that it completely replaces the semantic content of the concept of "citizenship". At the same time, there is a tendency to militarize the concept of patriotism both at the level of constructing its semantic content and in the course of representation practices, presented mainly through semantic categories and activities inextricably linked to military subjects. The authors record the discrepancy between the understanding of the semantic content of civic values by modern adolescents and the older generation. This situation suggests that the existing practices of representing patriotism are not fully consistent with the ideological demands of both the state and the younger generation, which indicates the need to search for new images of civic values.
Association between maternal anemia and low birth weight among stunting children 12−23 months in Dili, Timor Leste
Authors: Florencia Grifit Joiner Da Costa Hornay , Chandra Dian Novita , Lestari Wiji 
Published: February 2025

Background: Stunting is a chronic malnutrition problem primarily occurring during the first 1000 days of life. Iron deficiency anemia during pregnancy can threaten fetal growth and may affect the baby's birth weight and length. According to the Timor-Leste Food and Nutrition Survey 2020, stunting in Timor-Leste is 47.1%.
Objectives: To determine the relationship between a history of anemia during the third trimester of pregnancy and low birth weight with the incidence of stunting in children aged 12-23 months in Dili city.
Methods: This study was a case-control design conducted in five health centers in Dili City, Timor-Leste. The sample consists of 180 children aged 12-23 months, with 90 stunted cases and 90 controls selected consecutively. Data collected encompasses both child-related and maternal information.
Results: Anemia during the third trimester of pregnancy OR 95%CI 7.18 (3.38-15.23) and low birth weight OR 95%CI 5.39 (2.09 – 13.90) are significantly associated with the incidence of stunting (p < 0.01). Based on logistic regression analysis, anemia during pregnancy and low birth weight are not significantly associated with an increased risk of stunting. However, there are characteristics of the mother and child that are significantly associated with the risk of stunting.
Conclusion: Children with a history of low birth weight are 5.3 times more likely to experience stunting, and children whose mothers had anemia during pregnancy are 7.2 times more likely to experience stunting. The results show that low birth weight and maternal anemia are related to the incidence of stunting in Timor-Leste.
НАЧАЛЬНЫЙ ЭТАП ФОРМИРОВАНИЯ ОТЕЧЕСТВЕННОЙ ОРУЖЕЙНОЙ НАУКИ: В.Г. ФЁДОРОВ О БРОНЕЗАЩИТЕ ПЕХОТИНЦА НА РУБЕЖЕ 1900-1910-Х ГОДОВ
Authors: ТИМОФЕЕВА Р А. 
Published: February 2025

Статья посвящена анализу частного аспекта начального этапа формирования отечественной оружейной науки. Рассматривается проблема отношения к средствам индивидуальной бронезащиты пехотинца, в частности, один из первых научно обоснованных проектов в данной сфере - В.Г. Федорова. На основе материалов из государственных и ведомственных архивов реконструируются взгляды автора на данный вопрос. Рассматриваются разработанные В.Г. Федоровым образцы защитного вооружения.
The article is devoted on the analysis of a particular aspect of the initial stage of the formation of Russian weapons science. The problem of attitude to the means of individual armor protection of an infantryman is considered, in particular, one of the first scientifically based projects in this field - V.G. Fedorov. Based on materials from state and departmental archives, the author's views on this issue are reconstructed. The samples of protective weapons developed by V.G. Fedorov are analized.