bluuebunny/crossref_metadata_2025_split huggingface dataset:
Loss of ANCO1 repression at AIB1/YAP targets drives breast cancer progression
Authors: Kushner Max H , Ory Virginie , Graham Garrett T , Sharif Ghada M , Kietzman William B , Thevissen Sophia , Yuan Meng , Schmidt Marcel O , Wellstein Anton , Riegel Anna T 
Published: December 2019

AbstractTranscription factors critical for the transition of normal breast epithelium to ductal carcinoma in situ (DCIS) and invasive breast cancer are not clearly defined. Here, we report that the expression of a subset of YAP‐activated and YAP‐repressed genes in normal mammary and early‐stage breast cancer cells is dependent on the nuclear co‐activator AIB1. Gene expression, sequential ChIP, and ChIP‐seq analyses show that AIB1 and YAP converge upon TEAD for transcriptional activation and repression. We find that AIB1‐YAP repression of genes at the 1q21.3 locus is mediated by AIB1‐dependent recruitment of ANCO1, a tumor suppressor whose expression is progressively lost during breast cancer progression. Reducing ANCO1 reverts AIB1‐YAP‐dependent repression, increases cell size, and enhances YAP‐driven aberrant 3D growth. Loss of endogenous ANCO1 occurs during DCIS xenograft progression, a pattern associated with poor prognosis in human breast cancer. We conclude that increased expression of AIB1‐YAP co‐activated targets coupled with a loss of normal ANCO1 repression is critical to patterns of gene expression that mediate malignant progression of early‐stage breast cancer.
“ACCORDING TO THE BROTHERHOODS’ CUSTOM” BANQUETS OF KYIV CRAFTSMEN OF THE SECOND HALF OF XVIII CENTURY
Authors: Sokyrko Oleksii 
Published: December 2019

Nutrition has always been an important element of the subculture of different social communities of Early Modern Europe. Holiday feasts of craftsmen corporations in the cities performed symbolic functions, separating the socio-professional community from the rest of society, and at the same time demonstrated its status, wealth, prestige. The joint banquets of craftsmen on the occasion of church holidays and corporate events strengthened group identity, saved it from blurring, restrained the isolation and individualization of its members. The several-day banquets held after the church liturgies were accompanied by music and hearty feasts, gifts to the clergy patrons of the craft and magistrate officials, and demonstrated the material power of the craft brotherhood and the respectful social status of its members.
The books of Kyiv craft corporations allow to reconstruct the middle-class townsfolk cuisine of the middle - second half of the 18th century. According to the expenditure registers contained in them, it is evident that the townsfolk gastronomic tradition retained all the features inherent in the late medieval food system. It was dominated by the meals and drinks that formed the basis of nutrition for the high and the middle-class: large amounts of meat, fresh and salted fish, thick crunchy soups and cereals, white bread, vodka (horilka), mead and beer.
The culinary culture of craftsmen was no stranger to imitation of higher gastronomic patterns and habits. In early modern Kyiv, the monastic world and the everyday culture of the church hierarchs acted as a model for imitation. This is where the artisans borrowed their taste for the use of tea, caviar and sturgeon. Another model to follow was the merchants, whose table was rich in various spices, imported alcohol, vegetables, fruits and sweets. Less significant, but noticeable, was the influence of the household fashion of the Cossack officials (starshyna) and the LittleRussian nobility (shliakhta): wildfowl, lavish local and imported liquers (vodka) appeared on the townspeople's tables. For all its ostentatious personality and efforts to imitate the cuisine of the upper classes, the food style of the craftsmen was far from cosmopolitanism. In the kitchen of Kyivites we will not see manifestations of culinary fashion of the XVIII century. The periphery of Kyiv's economic and administrative status made the food of its inhabitants quite typical of the rest of the country, having preserved the noticeable features of the food structure that had been developed in the previous XVII century. In the case of craft corporate records, we can see literally microscopic changes - the appearance of cheap spices, sugars, inexpensive imported wines in the diet of burghers, which were markers of sluggish economic changes
BETWEEN CITY AND VILLAGE: FOOD CONSUMPTION PRACTICES IN THE EVERYDAY LIFE OF THE UKRAINIAN INTELLIGENTSIA (THE LATE 19th – EARLY 20th CC.)
Authors: Kazakevych Olga 
Published: December 2019

The article is devoted to the food consumption practices of the Ukrainian-minded educated class during the late 19th – early 20th cc. It is based mainly on the memoirs and diaries. The author considers the fact that the intelligentsia was a relatively new social stratum which came into being by the middle of the 19th c. Most of its representatives, whether they were descendants of gentry or peasants, originated from the non-urban area. The Ukrainian-minded intellectuals maintained their connections with the countryside and its culture, spending their vacations in the rural area, hiring former peasants as cook-housekeepers etc. The author assumes that this was the main reason why the tastes and food habits of Ukrainian intelligentsia were to a large extent influenced by the traditional rural cuisine. It is clearly visible in the descriptions of the Christmas and Easter celebrations when mostly traditional dishes used to be cooked. Keeping a fast was also a common practice for both Orthodox rural population and the urban intelligentsia. As the author points out, meetings of the Ukrainian-minded intellectuals in Kyiv were usually accompanied by the feasts and banquets. At these banquets, the demonstration of hospitality and largess was highly important and the dishes of people’s cuisine (recognized as national and democratic) were especially popular. However, a new experience of consuming international food and drinks in the urban milieu progressively transformed tastes of the Ukrainian intelligentsia. Travelling abroad contributed significantly to the changing of domestic food practices. In general, the author comes to the conclusion that during the late 19th – early 20th cc. food consumption practices of the Ukrainian intelligentsia used to be a mixture of the Ukrainian gastronomic traditions and international (mostly European) cuisine.
Factors Influencing Career Longevity in Pediatric Hospital Medicine
Authors: House Samantha , Frintner Mary Pat , Leyenaar JoAnna K. 
Published: December 2019

BACKGROUND AND OBJECTIVES:
Pediatric hospital medicine (PHM) is a growing field recently approved by the American Board of Pediatrics as a subspecialty. Understanding factors associated with hospitalist retention is important for workforce planning. Our objective for this study was to examine the proportion of pediatric hospitalists who remained in PHM over a 5-year period and identify factors associated with retention.

METHODS:
We used 2012 and 2016 data from the American Academy of Pediatrics’ Pediatrician Life and Career Experience Study. Retention was defined as being a self-reported hospitalist on both surveys. χ2 tests were used to examine relationships between retention and variables within 3 categories: demographics, position-related factors, and factors related to stress and satisfaction. A multivariable logistic regression was used to further assess relationships between select factors and retention.

RESULTS:
In 2012, 206 of 1804 survey respondents were hospitalists (11%); 180 of these 206 individuals responded again in 2016, and 122 (68%) remained hospitalists. In the multivariable analysis, individuals earning ≥$175 000 were more likely than those earning less (adjusted odds ratio [aOR] = 3.93; 95% confidence interval [CI]: 1.26–12.25) and those more satisfied with their job were more likely than those less satisfied (aOR = 3.28; 95% CI: 1.22–8.80) to remain hospitalists. Respondents with more concern about educational debt were less likely than those less concerned to remain hospitalists over 5 years (aOR = 0.42; 95% CI: 0.20–0.90).

CONCLUSIONS:
Two-thirds of early- to mid-career hospitalists remained in PHM 5 years later. Financial factors and job satisfaction appear to play an important role in retention; consideration should be given to the impact of these factors on the PHM workforce.
RİO OLİMPİYAT OYUNLARINDA BADMİNTON MÜSABAKALARININ İNCELENMESİ
Authors: TÜRKELİ Anıl , ŞENEL Ömer , GÜLMEZ İrfan 
Published: December 2019

Bu araştırmada, 2016 Rio Olimpiyatları badminton
müsabakalarının genel analizi yapılarak, daha önce düzenlenen Olimpiyat
Oyunları (2004 Atina, 2008 Pekin, 2012 Londra) badminton müsabakaları ile
karşılaştırılması amaçlanmıştır.Bu çalışmada, veri toplama
aracı olarak 2016 Rio Olimpiyat Oyunlarının resmi internet sayfası kullanılmış,
müsabakalar süresince bu sayfada yayınlanan toplam 206 müsabakanın sonuç ve
analizleri kaydedilerek değerlendirmeye alınmıştır. Araştırma, 41 ülkeden
olimpiyat vizesi almış 85 kadın ve 87 erkek sporcu olmak üzere toplam 172
sporcuya ait veriler kullanılarak gerçekleştirilmiştir.Bu araştırma sonucunda; toplam
maç süreleri ortalama olarak tekler ve çiftler kategorilerinde sırasıyla;
erkekler 46,37±14,62 dk., 53,42±18,91 dk., kadınlar 42,44±13,09 dk., 53±16,81
dk., olarak belirlenmiştir. Karışık çiftlerde ise bu süre 46,78±14,99 dk.
olarak tespit edilmiştir. En uzun ralli süreleri ortalaması tek erkek ve kadınlarda
sırasıyla 43.6±16.77 sn., 36.96±13.77 sn., çift erkek, çift kadın ve karışık
çiftler kategorilerinde sırasıyla; 40.18±18.06 sn., 53.53±17.69 sn. ve
33.75±10.32 sn.’ dir.

Bu araştırmada
elde edilen veriler geçmiş Olimpiyat Oyunları ile karşılaştırıldığında, toplam
maç süresi ortalaması, en uzun ralli süre ortalaması ve en yüksek ralli vuruş
sayısı ortalamasının artmış olduğu görülmektedir.
TRADITIONAL MUSIC AND POETRY OF THE TATARS-MISHARS: MODERN FORMS OF EXISTENCE
Authors: Vladimirovna Karkina Svetlana , Khabibullovna Nurgayanova Nelya , Kaur Manpreet 
Published: December 2019

Purpose: The Tatars-Mishars are an ethnographic group of the middle Volga and Ural Tatars. Their speech is based on a special dialect and belongs to the Western group of the Tatar language. The Tatars-Mishars were settled on the Right Bank of the Volga in Mordovia, Chuvashia, Tatarstan, Bashkortostan, as well as in the Nizhny Novgorod, Penza, Ryazan, Samara, Saratov, and Ulyanovsk regions. The Mishar sub-ethnic group is divided into three ethnographic components – Sergach, Temnik, and lambir, each of which has its own linguistic and ethnocultural features. The object of our attention is the traditional musical and poetic creativity of the Tatar-Mishars of the Ulyanovsk region, which is a unique layer, characterized by the preservation and to date the existence of original folklore genres.
Methodology: In the article the analysis of the materials obtained by the authors during expeditions in the Ulyanovsk region, where the ignorance relating to the khvalynskoe, Karsunsky and melekessky language groups. As a result of research various and interesting, to some extent, the original material was recorded. When collecting information, the instruction on collecting musical folklore was used for detailed certification of the recorded sample, which allowed to identify the distribution area, local features, the picture of the modern functioning of the works of traditional musical and poetic creativity.
Results: In general, the study showed that the traditional musical culture of the Tatar-Mishars of the Ulyanovsk region, is a distinctive layer, characterized by a variety of genres and styles. This lyrical lingering and short tunes, takmaks and lyric-epic genres baits, munajat.
Application: Therefore, the study and preservation for future generations of musical and poetic folklore of the Tatar-Mishars, which has inexhaustible wealth, will allow feeling the original and universal foundations of spirituality of the Tatar people and its culture.
THE MANIPULATIVE CAPACITY OF MASS MEDIA
Authors: Nikolaevna Goryacheva Olga , Sergeevna Kalinina Galina 
Published: December 2019

Purpose: The relevance of work is connected with understanding that the policy turns into the media process. Problematic is an allocation in a huge flow of information of the most priority and significant: consciousness of the recipient is considerably overloaded; the individual does not manage to carry out the analysis of the obtained information, and only gives it a superficial emotional assessment
Methodology: The method of comparison is used for the correlation of political media reality with reality. The method of the analysis of empirical data of political activity promotes the establishment of the truth in the registration of media materials.
Result: In the article, the levers used in mass media are analyzed, their manipulative potential is defined. Special attention is paid to the fact that virtualization of political reality in mass media leads to the emergence of ideological symbols. The practical importance of research of manipulative capacity of mass media consists of the identification of peculiar features, forms, and methods of impact on the consumer of information content.
Applications: This research can be used for universities, teachers, and students.
Novelty/Originality: In this research, the model of The manipulative capacity of mass media is presented in a comprehensive and complete manner.
Exploración de instrumentos que evalúan recursos resilientes en población infantil argentina
Authors: Hendrie Kupczyszyn Karina Noelia 
Published: December 2019

Las adversidades sociales, económicas, físicas y psicológicas a las que están expuestos algunos grupos poblacionales infantiles, comprometen seriamente su desarrollo y desempeño, restándoles bienestar y calidad de vida. En los últimos años, se ha otorgado gran relevancia a los estudios dedicados al concepto de resiliencia y su medición por el aporte que este constructo ha provisto para entender la forma en que los individuos pueden sobrellevar las situaciones de crisis e infortunio y aun salir fortalecidos a pesar de las circunstancias. La identificación y el diagnóstico de los recursos resilientes se ha vuelto entonces una meta de gran significación para la disciplina psicológica. El objetivo de este estudio fue sistematizar la información referida a instrumentos de medición creados y validados en los últimos años para la evaluación de fortalezas o recursos resilientes en niños de la Argentina. Para la recolección de datos, se analizaron diferentes estudios científicos, entre ellos artículos de revistas, tesis de grado y posgrado, identificando así 17 instrumentos de medición para evaluar recursos resilientes en el periodo de la niñez. Todos ellos presentan propiedades psicométricas apropiadas y permiten explorar de manera válida y confiable la presencia de numerosos recursos resilientes en los niños argentinos.
Rasgos de personalidad disfuncional en estudiantes universitarios de Buenos Aires
Authors: Stover Juliana Beatriz 
Published: December 2019

En la sección III del DSM-5 se propone un modelo alternativo para evaluar los trastornos de personalidad, en cuyo criterio B se postula un modelo dimensional de rasgos disfuncionales de personalidad compuesto por cinco dominios y 25 rasgos. El objetivo de este trabajo fue analizar dichos dominios y rasgos en estudiantes universitarios de Buenos Aires. La muestra se compuso de 453 estudiantes universitarios de instituciones públicas y privadas (52.30% mujeres, 47.70% varones) con edades comprendidas entre los 18 y 35 años (M = 24.26, DE = 3.73). Se recolectaron datos con una encuesta sociodemográfica y de datos académicos básicos, así como con el Inventario para Trastornos de la Personalidad para el DSM‐5 (PID-5). Para analizar diferencias en los dominios y rasgos según sexo y tipo de carrera se llevaron a cabo análisis de MANOVA. Se calcularon correlaciones r de Pearson para examinar la asociación de los dominios y rasgos con el rendimiento académico. Se halló que las mujeres presentaron medias superiores Afecto Negativo, Ansiedad y Labilidad Emocional, y los hombres, en Antagonismo, Búsqueda de Atención, Insensibilidad, Engaño, Grandiosidad, Manipulación, Toma de Riesgo y Excentricidad. Examinado diferencias según tipo de carrera, se detectó un patrón de medias inferiores en los alumnos de Ciencias Humanas. Al analizar el vínculo con el rendimiento académico, se encontraron asociaciones negativas con el índice de aprobación, mientras que positivas con los índices de aplazos, asignaturas libres y recursadas. En conclusión, se efectuó una primera aproximación al estudio del modelo de rasgos disfuncionales en población local universitaria, analizado su vínculo con variables sociodemográficas y académicas.
NEGOTIATING MOTHERHOOD IN CONSTRAINING SPACE IN EMMA DONOGHUE’S ROOM
Authors: Aisyah Putti , Ayu Hujuala Rika 
Published: December 2019

<p align="justify">This study sheds light on how Ma, the female character in Emma Donoghue’s <em>Room</em> negotiates her roles as a mother of a five-years-old Jack while living inside a constraining room built by Nick, her kidnapper. It particularly focuses on how Ma attempts to re-define her motherhood within built and discursive spaces that Nick constructs. The study employs the concepts of Sarah Ruddick on maternal thinking and Marsha Marotta’s MotherSpace. Marrota delineates two spatial aspects contributing to shape mother’s subjectivity; built spaces and discursive spaces. Built space is the 11x11m room representing Nick’s authority. Nick also partly constructs the discursive space within the room. The finding shows that Ma is able to create her own discursive space as her effort of conforming her motherhood, within the constraining built space. Ma successfully performs her sense of motherhood – such as providing him physical needs like nutritious food and nurturing his cognitive development.</p>
Türkiye’deki Feldspat Rezervlerinde Radyoaktivite Düzeyleri
Authors: Altıkulaç Aydan 
Published: December 2019

Yer kabuğunun %60’ını oluşturan feldspat, en önemli
mineral gruplarındandır. Magmanın farklı kısımlarında değişik şekillerde
bulunan bu minerallerin soğuyup kristalleşmesiyle feldspat zonları ve yatakları
oluşmuştur. Özellikle seramik, porselen ve cam sanayinde olmak üzere birçok
sektörde önemli bir ham madde olan feldspat rezervinin yaklaşık %14 ‘ü
Türkiye’dedir. Bu anlamda Türkiye, dünya
feldspat rezervi açısından zengin kategorisinde yer almaktadır ve önemli bir
ihracat payına sahiptir. Feldspat minerali yer kabuğu kökenli olup magmatik,
metamorfik ve sedimenter kayaçların yapısında bulunur ve doğal radyasyon ihtiva
eder. Rezerv kaynaklarının değerlendirilmesi ülke madenciliğinin öncelikli
konularından olsa da konut ve iş yeri binalarının yapımında kullanılan ham
maddenin içerdiği 226Ra, 232Th, 40K ve 137Cs izotoplarının
radyoaktivite düzeylerinin bilinmesi insan sağlığı bakımından oldukça
önemlidir. Bu amaçla Türkiye’nin en önemli feldspat zonlarının bulunduğu maden
yataklarından (Aydın, Muğla, Manisa ve Kırşehir) alınan örneklerde
radyoaktivite analizleri yapıldı. Gama Spektrometre Sistemi kullanılarak
yapılan analizler neticesinde 226Ra, 232Th, 40K ve 137Cs radyoizotoplarına
ait ortalama aktivite konsantrasyonlarının sırasıyla 11.94±3.8, 4.28±1.7, 879.26±56.3 ve 1.9±0.7 Bqkg-1 olduğu
tespit edildi. Bu aktivitelerden kaynaklanan radyolojik risk analizi yapıldı.
Intrathecal Baclofen Infusion Pumps in the Treatment of Spasticity: A Retrospective Cohort Study in a Portuguese Centre
Authors: Reis Pedro Videira , Vieira Catarina Rocha , Midões Ana Cristina , Rebelo Virginia , Barbosa Paula , Gomes Armanda 
Published: December 2019

Introduction: Spasticity is a complex problem in patients with neurological disorders and may distress their quality of life. Intrathecal baclofen infusion pumps reduce spasticity with low doses and minimal side effects but are not free from complications. We aimed to evaluate the efficacy and safety of intrathecal baclofen infusion pumps as well as patients’ satisfaction.Material and Methods: Retrospective cohort study including all intrathecal baclofen infusion pumps placed up to December 2015. Demographic characteristics, clinical diagnoses, date of placement or withdrawal/replacement of intrathecal baclofen infusion pumps, baclofen dosage and complications of intrathecal baclofen infusion pumps were collected. Assessments from the Ashworth and Penn’s scales, Katz index and patients’ global satisfaction were analysed.Results: In 19 years we placed 251 intrathecal baclofen infusion pumps in 155 patients. The mean age was 41.1 ± 15.8 years. The most frequent conditions were: trauma (34%), cerebral palsy (14%), multiple sclerosis (12%) and stroke (12%). Eighty-five patients (55%) required a second pump, and eleven (7%) a third one. The lifetime of the first pump was 72 (36 – 89) and the total follow-up time was 96 (9 – 132) months. The causes of withdrawal/replacement were: battery failure (57%), catheter migration/kinking (24%), infection (14%) and pump displacement/exteriorization (7%). The complication rate was 0.21 events/month. There was a significant improvement in the Ashworth and Penn’s scales after the placemen of intrathecal baclofen infusion pumps (p < 0.001 for all diagnoses) and the patients were satisfied with the treatment.Discussion: The incidence of complications was within range of other international studies despite our long follow-up time. Events per month, loss to follow-up, re-intervention rate, incidence of infection and mortality were similar to other studies.Conclusion: Intrathecal baclofen infusion pumps are safe and effective in the treatment of spasticity. Infusion pumps provide a high level of satisfaction regarding treatment and quality of life.