bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fertility preservation and fulfillment of parenthood after treatment of hematological malignancies: results from the ‘Aftercare in Blood Cancer Survivors’ (ABC) study
Authors: Schmitz Christine , Baum Julia , Lax Hildegard , Lehmann Nils , Gromke Tanja , Beelen Dietrich W. , Jöckel K.-H. , Dührsen Ulrich 
Published: March 2020

Abstract
Purpose
Treatment of hematological malignancies carries the risk of lasting sterility. We aimed to identify fertility-related unmet needs.

Methods
The ‘Aftercare in Blood Cancer Survivors’ study is a cohort study of hematological patients who were in treatment-free remission for ≥ 3 years or stable under continuous oral medication. Female patients age 18–45 years and male patients age 18–65 years without a history of pre-treatment infertility were asked to answer a structured questionnaire including questions addressing fertility issues. Multivariable analyses were performed to detect risk factors.

Results
Of 1562 study participants, 1031 met the inclusion criteria for the fertility sub-study. A high proportion of patients (72.4%) received information about the risk of losing fertility, but only a minority (15%) took steps to preserve it. Female and older patients were less likely to be informed. A post-treatment wish for parenthood was expressed by 19.3% of patients. It was strongly associated with childlessness at time of diagnosis and could be fulfilled by 29.4%. Fulfillment of desired parenthood increased with increasing time from diagnosis and was low after allogeneic transplantation.

Conclusions
Female and older hematological patients are less likely to be informed about fertility-related issues than other patients. With societal changes towards first parenthood at higher age, the proportion of patients desiring a child after treatment is likely to increase. Fulfillment of desired parenthood remains challenging, especially after allogeneic transplantation.

Implications for cancer survivors
In patients likely to express a wish for post-treatment parenthood, fertility-related issues should routinely be addressed before gonadotoxic treatment is started.
Construction of a “nutrition supply–detoxification” coculture consortium for medium-chain-length polyhydroxyalkanoate production with a glucose–xylose mixture
Authors: Liu Yaru , Yang Songyuan , Jia Xiaoqiang 
Published: March 2020

Abstract
In this study, we constructed a coculture consortium comprising engineered Pseudomonas putida KT2440 and Escherichia coli MG1655. Provision of “related” carbon sources and synthesis of medium-chain-length polyhydroxyalkanoates (mcl-PHAs) were separately assigned to these strains via a modular construction strategy. To avoid growth competition, a preference for the use of a carbon source was constructed. Further, the main intermediate metabolite acetate played an important role in constructing the expected “nutrition supply–detoxification” relationship between these strains. The coculture consortium showed a remarkable increase in the mcl-PHA titer (0.541 g/L) with a glucose–xylose mixture (1:1). Subsequently, the titer of mcl-PHA produced by the coculture consortium when tested with actual lignocellulosic hydrolysate (0.434 g/L) was similar to that achieved with laboratory sugars’ mixture (0.469 g/L). These results indicate a competitive potential of the engineered E. coli–P. putida coculture consortium for mcl-PHA production with lignocellulosic hydrolysate.
A semidiscrete Galerkin scheme for a coupled two-scale elliptic–parabolic system: well-posedness and convergence approximation rates
Authors: Lind Martin , Muntean Adrian , Richardson Omar 
Published: March 2020

AbstractIn this paper, we study the numerical approximation of a coupled system of elliptic–parabolic equations posed on two separated spatial scales. The model equations describe the interplay between macroscopic and microscopic pressures in an unsaturated heterogeneous medium with distributed microstructures as they often arise in modeling reactive flow in cementitious-based materials. Besides ensuring the well-posedness of our two-scale model, we design two-scale convergent numerical approximations and prove a priori error estimates for the semidiscrete case. We complement our analysis with simulation results illustrating the expected behaviour of the system.
What Shall We Eat? An Ethical Framework for Well-Grounded Food Choices
Authors: Höglund Anna T. 
Published: March 2020

AbstractIn production and consumption of food, several ethical values are at stake for different affected parties and value conflicts in relation to food choices are frequent. The aim of this article was to present an ethical framework for well-grounded decisions on production and consumption of food, guided by the following questions: Which are the affected parties in relation to production and consumption of food? What ethical values are at stake for these parties? How can conflicts between the identified values be handled from different ethical perspectives? Four affected parties, relevant for both production and consumption of food, were identified, namelyanimals, nature, producersandconsumers.Working form a bottom-up perspective, several values for these parties were identified and discussed. For animals:welfare, not being exposed to painandnatural behavior; for nature:low negative impact on the environmentandsustainable climate; for producers:fair salariesandsafe working conditions; and for consumers:access to food, autonomy, healthandfood as part of a good life. As several of these values can come into conflict when choices of what to eat should be made, the article argues for the need of weighing values from four different perspectives in food ethics dilemmas, namelyduties, consequences, virtuesandcare.The suggested ethical framework can provide moral guidance to both producers of food and to consumers in a supermarket. Thereby, it can contribute to more well-grounded decisions concerning what to eat and make people feel a little bit more secure when reflecting over the question: What shall we eat?
Fock representations of ZF algebras and R-matrices
Authors: Lechner Gandalf , Scotford Charley 
Published: March 2020

AbstractA variation of the Zamolodchikov–Faddeev algebra over a finite-dimensional Hilbert space$${\mathcal {H}}$$Hand an involutive unitaryR-MatrixSis studied. This algebra carries a natural vacuum state, and the corresponding Fock representation spaces$${\mathcal {F}}_S({\mathcal {H}})$$FS(H)are shown to satisfy$${\mathcal {F}}_{S\boxplus R}({{\mathcal {H}}}\oplus {{\mathcal {K}}}) \cong {\mathcal {F}}_S({{\mathcal {H}}})\otimes {\mathcal {F}}_R({{\mathcal {K}}})$$FS⊞R(H⊕K)≅FS(H)⊗FR(K), where$$S\boxplus R$$S⊞Ris the box-sum ofS(on$${{\mathcal {H}}}\otimes {{\mathcal {H}}}$$H⊗H) andR(on$${{\mathcal {K}}}\otimes {{\mathcal {K}}}$$K⊗K). This analysis generalises the well-known structure of Bose/Fermi Fock spaces and a recent result of Pennig. These representations are motivated from quantum field theory (short-distance scaling limits of integrable models).
Writing about women in ghost stories: subversive representations of ideal femininity in “Nie Xiaoqian” and “Luella Miller”
Authors: Zheng Yi 
Published: March 2020

AbstractOn the one hand, because of the double historical prejudices from literary criticism against ghost stories and women’s writing, little attention has been paid to investigate the ideals of femininity in women’s ghost stories in nineteenth-century America. This article examines “Luella Miller,” a short story by Mary E. Wilkins Freeman, who indirectly but sharply criticized the ideal of femininity in her time by creating an exaggerated example of the cult of feminine fragility. On the other hand, although extensive research has been done on Chinese ghost stories, especially on the ghost heroines in Pu Songling’sStrange Stories from a Chinese Studio, there are few studies comparing the Chinese and the American ones. By comparing “Luella Miller” and Pu’s “Nie Xiaoqian,” this article does not primarily aim to list the similarities and differences between the Chinese and the American ideals of femininity, but to provide fresh insights into how both Freeman and Pu capitalized on the literary possibilities of the supernatural, because only in ghost stories they could write about women in ways impossible in “high literature.”
The positive maximum principle on symmetric spaces
Authors: Applebaum David , Le Ngan Trang 
Published: March 2020

AbstractWe investigate the Courrège theorem in the context of linear operators that satisfy the positive maximum principle on a space of continuous functions over a symmetric space. Applications are given to Feller–Markov processes. We also introduce Gangolli operators, which satisfy the positive maximum principle, and generalise the form associated with the generator of a Lévy process on a symmetric space. When the space is compact, we show that Gangolli operators are pseudo-differential operators having scalar symbols.
Long-term change in calcareous grassland vegetation and drivers over three time periods between 1970 and 2016
Authors: Ridding Lucy E. , Bullock James M. , Pescott Oliver L. , Hawes Peter , Walls Robin , Pereira M. Glória , Thacker Sarah A. , Keenan Patrick O. , Dragosits Ulrike , Pywell Richard F. 
Published: March 2020

AbstractAnalysis of long-term vegetation change is limited. Furthermore most studies evaluating change only examine two snapshots in time, which makes it difficult to define rates of change and accurately assess potential drivers. To assess long-term change in calcareous grassland over multiple time periods, we re-surveyed a transect study undertaken at Parsonage Down National Nature Reserve, Wiltshire, southern England in 1970 and 1990 by T. Wells. We examined differences in soil properties and species traits in each of the survey years to understand potential drivers of vegetation change, including nitrogen deposition and grazing management. There was a clear shift in species composition, combined with significant declines in species richness and diversity between 1970 and 2016, with the greater rate of change occurring between 1990 and 2016. A significant increase in soil total nitrogen was found, which was significantly associated with the decline in species diversity between 1970 and 1990. Significant changes in community-weighted mean traits were identified for plant height (increasing), specific leaf area (decreasing), grazing tolerance (decreasing) and Ellenberg N (decreasing) between 1970 and 2016. By using survey data from multiple time periods, we suggest that N deposition may have contributed towards community changes between 1970 and 1990, as indicated by the change in soil properties and the associated decline in species diversity. Vegetation change between 1990 and 2016 is likely to be largely attributable to a decline in grazing pressure, indicated by the increase in taller species and a decrease in grazing tolerance.
Negotiating Authority: Local Communities in the World Heritage Convention
Authors: Trelka Małgorzata 
Published: March 2020

AbstractThe Operational Guidelines for the implementation of the World Heritage Convention stipulate that local communities and indigenous peoples are an intrinsic part of the identification, nomination, management and protection of World Heritage sites (UNESCO 2019, art. 12). This paper explores the role of local communities in the World Heritage system by critically assessing the implementation of the Convention in a European context through the case study of the Ironbridge Gorge WHS. The case study is contextualised in the representation of indigenous peoples in World Heritage policies negotiating their intellectual and legal authority in the World Heritage process facilitated through heritage bureaucracy. This paper will address the internationally important issue of power relations when it comes to the inclusion of local communities and indigenous peoples in the World Heritage Convention and in heritage practice.
Long-term cultivation using ineffective MDM2 inhibitor concentrations alters the drug sensitivity profiles of PL21 leukaemia cells
Authors: Michaelis Martin , Rothweiler Florian , Schneider Constanze , Rothenburger Tamara , Mernberger Marco , Nist Andrea , Stiewe Thorsten , Cinatl Jindrich 
Published: March 2020

AbstractAcquired MDM2 inhibitor resistance is commonly caused by loss-of-function TP53 mutations. In addition to the selection of TP53-mutant cells by MDM2 inhibitors, MDM2 inhibitor-induced DNA damage may promote the formation of TP53 mutations. Here, we cultivated 12 sublines of the intrinsically MDM2 inhibitor-resistant TP53 wild-type acute myeloid leukaemia cell line PL21 for 52 passages in the presence of ineffective concentrations of the MDM2 inhibitor nutlin-3 but did not observe loss-of-function TP53 mutations. This suggests that MDM2 inhibitors select TP53-mutant cells after mutations have occurred, but do not directly promote TP53 mutations. Unexpectedly, many sublines displayed increased sensitivity to the anti-cancer drugs cytarabine, doxorubicin, or gemcitabine. Consequently, therapies can affect the outcome of next-line treatments, even in the absence of a therapy response. This finding is conceptually novel. A better understanding of such processes will inform the design of improved therapy protocols in the future.
Escalating infection control response to the rapidly evolving epidemiology of the coronavirus disease 2019 (COVID-19) due to SARS-CoV-2 in Hong Kong
Authors: Cheng Vincent C. C. , Wong Shuk-Ching , Chen Jonathan H. K. , Yip Cyril C. Y. , Chuang Vivien W. M. , Tsang Owen T. Y. , Sridhar Siddharth , Chan Jasper F. W. , Ho Pak-Leung , Yuen Kwok-Yung 
Published: March 2020

AbstractObjective:To describe the infection control preparedness measures undertaken for coronavirus disease (COVID-19) due to SARS-CoV-2 (previously known as 2019 novel coronavirus) in the first 42 days after announcement of a cluster of pneumonia in China, on December 31, 2019 (day 1) in Hong Kong.Methods:A bundled approach of active and enhanced laboratory surveillance, early airborne infection isolation, rapid molecular diagnostic testing, and contact tracing for healthcare workers (HCWs) with unprotected exposure in the hospitals was implemented. Epidemiological characteristics of confirmed cases, environmental samples, and air samples were collected and analyzed.Results:From day 1 to day 42, 42 of 1,275 patients (3.3%) fulfilling active (n = 29) and enhanced laboratory surveillance (n = 13) were confirmed to have the SARS-CoV-2 infection. The number of locally acquired case significantly increased from 1 of 13 confirmed cases (7.7%, day 22 to day 32) to 27 of 29 confirmed cases (93.1%, day 33 to day 42; P < .001). Among them, 28 patients (66.6%) came from 8 family clusters. Of 413 HCWs caring for these confirmed cases, 11 (2.7%) had unprotected exposure requiring quarantine for 14 days. None of these was infected, and nosocomial transmission of SARS-CoV-2 was not observed. Environmental surveillance was performed in the room of a patient with viral load of 3.3 × 106 copies/mL (pooled nasopharyngeal and throat swabs) and 5.9 × 106 copies/mL (saliva), respectively. SARS-CoV-2 was identified in 1 of 13 environmental samples (7.7%) but not in 8 air samples collected at a distance of 10 cm from the patient’s chin with or without wearing a surgical mask.Conclusion:Appropriate hospital infection control measures was able to prevent nosocomial transmission of SARS-CoV-2.
Comparative Perspectives on the Urban Black Atlantic on the Eve of Abolition
Authors: Klooster Wim 
Published: March 2020

AbstractBy investigating the place of enslaved Africans and their descendants in the cities of the Atlantic world, this article explores many of the themes of this Special Issue across empires, with an emphasis on the Americas in the late eighteenth century, the eve of abolition. The article finds that, in nearly every manual occupation, slaves were integrated with free laborers and, not infrequently, slaves who had reached the level of journeyman or master directed the work of free apprentices. The limited number of slave insurrections in cities may be explained by the fact that they often worked semi-independently, earning money to supplement the livelihood provided by the master, or sometimes almost entirely on their own. To them, city life offered advantages that would have been inconceivable for their rural counterparts, especially the scope of autonomy they enjoyed and the possibilities to secure manumission.
Bernstein mode acceleration of electrons in a magnetic mirror
Authors: Jeet Ram , Kumar Asheel 
Published: March 2020

AbstractElectron dynamics in an axially localized large amplitude electron Bernstein mode in a magnetic mirror is studied. The mode is localized due to plasma density and magnetic field profiles and could be driven by an electron cyclotron wave, launched from outside, via linear mode conversion. Energetic electrons of finite gyro-radius resonantly interact with the mode and gain primarily transverse energy favoring stronger mirror confinement. At Bernstein wave normalized amplitude of A00 = 0.01 and for other normalized parameters Zn0 = 40, k⊥c/ω = 10, ${L}^{\prime}_m = 215$, ωc0/ω = 0.9, ψn0 = 3π/2, the electrons can gain energy in the hundreds of keV range.
Bidirectional coronary venous return in the partial unroofed coronary sinus syndrome complicated by coronary sinus orifice atresia
Authors: Asada Dai , Ito Hisato 
Published: March 2020

AbstractUnroofed coronary sinus syndrome complicated by coronary sinus orifice atresia is a rare congenital anomaly. There are two alternate exits for coronary venous return: unroofed coronary sinus and persistent left superior caval vein. The coronary venous direction could be bidirectional depending on the pressure balance between the left atrium and the systemic vein. This anomaly has the risk of heart failure, paradoxical embolism, and cyanosis.
General Practitioner House Call Network (SOS Médecins): An Essential Tool for Syndromic Surveillance – Bordeaux, France
Authors: Meurice Laure , Chapon Thierry , Chemin Frédéric , Gourinchas Laurence , Sauvagnac Stéphane , Uijttewaal Sébastien , Vandentorren Stéphanie 
Published: March 2020

AbstractIntroduction:In the French mainland administrative region Nouvelle-Aquitaine, syndromic surveillance is based on hospital emergency data, mortality data, and data from associations belonging to the SOS Médecins network. The aim of the present article is to describe the functioning of this network and to illustrate its use for syndromic surveillance in Nouvelle-Aquitaine.Method:The SOS Médecins network participates in the syndromic surveillance system SurSaUD, developed by Santé publique France (SpF; the French National Public Health Agency; Saint-Maurice, Paris, France). Near real-time data are automatically transmitted daily to a data server and analyzed by SpF’s Nouvelle Aquitaine’s regional unit to identify, monitor, and evaluate the impact of expected and unexpected health events in the region.Results:The SOS Médecins network has five local associations spread across the region with 146 participating physicians. Data have been recorded for more than 10 years and represented nearly 481,000 visits in 2017. The resulting database has helped to identify and monitor seasonal epidemics and unexpected events, as well as measure the health impact of these events.Conclusion:The data from the SOS Médecins network are an essential source in syndromic surveillance. They complement surveillance data from other sources. More specifically, mortality and emergency unit traffic reflect the most severe cases, while SOS Médecins data help early detection of epidemics and health events in the general population. The network has shown its responsiveness and its reliability, not only for the surveillance of seasonal epidemics, but also for the detection of unusual signals. It therefore constitutes an essential link in syndromic surveillance in France, and specifically in the Nouvelle-Aquitaine region.
Metabolic profiling of glyphosate-resistant sourgrass (Digitaria insularis)
Authors: Gazola Tiago , Bianchi Leandro , Dias Márcio Furriela , Carbonari Caio A. , Velini Edivaldo D. 
Published: March 2020

AbstractPutative glyphosate-resistant sourgrass was collected to determine its resistance level and to evaluate its metabolic profile after resistance. Although accumulation of shikimic acid is known to occur in glyphosate-susceptible populations, differences in the ability of resistant (R) and susceptible (S) biotypes to accumulate quinic acid, salicylic acid, and aminomethylphosphonic acid (AMPA) have been studied to a lesser extent. Our objective was to confirm glyphosate resistance in sourgrass and to understand the metabolic profile of these plants in response to the herbicide. Greenhouse experiments were carried out from January 2016 to June 2018. There were no significant differences in glyphosate translocation in the plants. No metabolism of glyphosate to AMPA was observed; therefore, metabolism of glyphosate to AMPA is not a mechanism in R biotypes. S biotypes showed higher concentrations of shikimic acid and quinic acid before glyphosate and accumulated less of both secondary acids in treated leaves 72 h after glyphosate application. Resistant biotypes showed higher concentrations of salicylic acid before glyphosate application.
Associations of accelerometer-measured physical activity and physical activity-related cancer incidence in older women: results from the WHI OPACH Study
Authors: Parada Humberto , McDonald Emily , Bellettiere John , Evenson Kelly R. , LaMonte Michael J. , LaCroix Andrea Z. 
Published: March 2020

AbstractBackgroundWe examined the associations between accelerometry-measured physical activity (PA) and incidence of 13 cancers among a cohort of postmenopausal women.MethodsIn this prospective study, 6382 women wore ActiGraph GT3X+ accelerometers at the hip for up to 7 days during 2012–2013, and were followed over a median of 4.7 years for diagnosis of 13 invasive cancers. Calibrated intensity cut points were used to define minutes per day of total, light and moderate-to-vigorous PA. We used multivariable Cox regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for tertiles, and one-standard deviation (SD) unit increments of PA exposures in relation to cancer incidence. We examined effect measure modification by age, race/ethnicity, body mass index and smoking history.ResultsThe highest (vs. lowest) tertiles of total, light and moderate-to-vigorous PA were associated with covariate-adjusted HRs of 0.72 (95% CI = 0.53–0.97), 0.81 (95% CI = 0.60–1.09) and 0.66 (95% CI = 0.48–0.91), respectively. In age-stratified analyses, HRs for total PA were lower among women <80 years (HRper one-SD = 0.75, 95% CI = 0.63–0.90) than among women ≥80 years (HRper one-SD = 0.99, 95% CI = 0.82–1.18) (PInteraction = 0.03). Race/ethnicity, BMI and smoking did not strongly modify these associations.ConclusionsEngaging in physical activity may play a beneficial role in the prevention of certain cancers in older women.
MIRAGE syndrome caused by a novel missense variant (p.Ala1479Ser) in the SAMD9 gene
Authors: Onuma Shinsuke , Wada Tamaki , Araki Ryosuke , Wada Kazuko , Tanase-Nakao Kanako , Narumi Satoshi , Fukui Miho , Shoji Yasuko , Etani Yuri , Ida Shinobu , Kawai Masanobu 
Published: March 2020

AbstractMIRAGE syndrome is a recently identified disorder characterized by myelodysplasia, infection, restriction of growth, adrenal hypoplasia, genital phenotypes, and enteropathy. It is caused by a gain-of-function variant in the SAMD9 gene, but there is limited knowledge regarding the genotype–phenotype correlation. We herein report a Japanese patient with MIRAGE syndrome carrying a novel de novo heterozygous missense variant in the SAMD9 gene (c.4435 G > T; p.Ala1479Ser).