bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Tingkat Kepadatan Penduduk Terhadap Indeks Pembangunan Manusia di Provinsi Bali
Authors: Antara I Gede Made Yudi , Suryana I Gede Putu Eka 
Published: July 2020

Penduduk dalam suatu wilayah sangat menentukan pembangunan di suatu wilayah. Sumber daya manusia yang erat kaitannya kuantitas dan kualitas penduduk harus menjadi perhatian pemerintah demi lancarnya pembangunan. Kuantitas dapat dilihat dari jumlah dan kepadatan penduduk, sedangkan kualitas penduduk suatu wilayah dapat dilihat dari Indeks Pembangunan Manusia (IPM) yang dicapai suatu wilayah. Provinsi Bali dengan kepadatan penduduk 743 jiwa/km2 memiliki IPM dengan kategori tinggi berdasarkan klasifikasi yang dikeluarkan oleh Badan Pusat Statistik. Tujuan dari penelitian ini adalah untuk mengetahui sejauh mana kuantitas penduduk yaitu kepadatan penduduk berpengaruh terhadap kualitas penduduk yang dilihat dari capaian IPM. Data sekunder yang diperoleh kemudian dianalisis secara kuantitaif dengan analisis regresi untuk mengetahui pengaruh dari kepadatan penduduk terhadap capaian IPM dan divisualisasikan dengan pemetaan digital menggunakan Arcview GIS 3.3. Hasil yang diperoleh bahwa kepadatan penduduk berpengaruh secara siginifikan terhadap capaian IPM, sehingga menunjukkan bahwa jumlah penduduk yang besar harus diiringi peningkatan kualitas sumber daya manusia.
An Elementary Proof for the Decomposition Theorem of Wright Convex Functions
Authors: Páles Zsolt 
Published: July 2020

Abstract
The main goal of this paper is to give a completely elementary proof for the decomposition theorem of Wright convex functions which was discovered by C. T. Ng in 1987. In the proof, we do not use transfinite tools, i.e., variants of Rodé’s theorem, or de Bruijn’s theorem related to functions with continuous differences.
Multifunctionality of Agriculture as a Significant Factor for Sustainable Rural Development of the Republic of Serbia
Authors: Ristić Lela , Despotović Danijela , Dimitrijević Miloš 
Published: July 2020

Abstract
The need for a modern agricultural development conditioned the concept of multifunctionality of agriculture. Multifunctionality of agriculture is often considered as a useful tool for achieving economic and sustainable development goals. It is increasingly gaining importance in the field of sustainable rural development by linking traditional and contemporary agricultural functions. Namely, sustainability of development requires food for people, but also other positive social, ecological and economic effects. The aim of this paper is to identify the most important indicators of agriculture from the point of multifunctionality of agriculture as a factor for sustainable rural development of the Republic of Serbia, and also compare rural indicators of the Western Balkan countries. The multivariate linear regression in the paper showed that more indicators of agriculture have impact on economy than on sustainable development of the Republic of Serbia, with particularly significance of rural population and its activity. Thereby, some statistical tests showed a decrease in rural population and employment in agriculture of the Western Balkan countries. It is concluded that support to multifunctionality of agriculture is of particular importance for sustainable rural development of the Republic of Serbia.
Structure and function of HECT E3 ubiquitin ligases and their role in oxidative stress
Authors: Qian Hao , Zhang Ying , Wu Boquan , Wu Shaojun , You Shilong , Zhang Naijin , Sun Yingxian 
Published: July 2020

Abstract
Ubiquitination is a modification after protein transcription that plays a vital role in maintaining the homeostasis of the cellular environment. The Homologous to E6AP C-terminus (HECT) family E3 ubiquitin ligases are a kind of E3 ubiquitin ligases with a C-terminal HECT domain that mediates the binding of ubiquitin to substrate proteins and a variable-length N-terminal extension. HECT-ubiquitinated ligases can be divided into three categories: NEDD4 superfamily, HERC superfamily, and other HECT superfamilies. HECT ubiquitin ligase plays an essential role in the development of many human diseases. In this review, we focus on the physiological and pathological processes involved in oxidative stress and the role of E3 ubiquitin ligase of the HECT family.
The role of mitochondria in vascular calcification
Authors: Wang Pengbo , Zhang Naijin , Wu Boquan , Wu Shaojun , Zhang Ying , Sun Yingxian 
Published: July 2020

Abstract
Vascular calcification (VC) was defined as the ectopic deposition of calcium–phosphorus complexes on the blood vessel walls. It was a process involving multiple factors and mechanisms, covering the phenotype transition of vascular smooth muscle cells (VSMCs) and release of microvesicles. It was a common end-stage alteration of chronic diseases such as cardiovascular disease and chronic kidney disease. Increasing evidence indicates that mitochondria were involved in the development of VC. Mitochondria provided energy to cells, maintained the stability of cell functions, and participated in a variety of biological behavior. Oxidative stress, autophagy, apoptosis, and mitochondrial DNA (mtDNA) damage could affect the development of VSMCs calcification by alteration of mitochondrial function. This article reviewed the mechanism of calcification and the role of mitochondria in VC, aiming to raise a novel insight into drug development and clinical treatment.
Autoimmune hepatitis: Clinical characteristics and predictors of biochemical response to treatment
Authors: Tasneem Abbas Ali , Luck Nasir Hassan 
Published: July 2020

Abstract

Background and Objectives
Autoimmune hepatitis (AIH) is an important cause of chronic liver disease. Aim of this study was to evaluate the clinical characteristics and factors predicting response to treatment in patients with AIH.

Methods
In this prospective observational study, all patients diagnosed with AIH from 2017 to 2019 were included. Biochemical response to the treatment was checked three months after the start of the treatment. Response was considered good if transaminases normalized, or poor if either remained persistently elevated or improved partially.

Results
Of the total 56 patients, 41 (73.2%) were females. Mean age was 29.5 (±16.9) years. About half (53.6%; n = 30) the patients were aged < 25 years and majority [47 (83.9%)] were cirrhotic. Autoimmune serology was negative in 20 (35.7%). Seronegativity was associated with severe necroinflammation (P = 0.015) and esophageal varices (P = 0.021). Response to treatment was good in 34 (60.7%). Bivariate analysis showed that good response to treatment was associated with pre-treatment serum IgG level > 20 g/L (P = 0.024), presence of pseudorosettes on histopathology (P = 0.029) and three months post-immunosuppression serum total bilirubin < 2mg/dL (P < 0.001). Multivariate logistic regression analysis showed that only pre-treatment serum IgG >20 g/L (P = 0.038) and post-treatment serum total bilirubin <2 mg/dL (P = 0.004) were independent predictors of good response to treatment.

Conclusion
Majority of AIH patients in our study were young and cirrhotic. A negative autoimmune serology does not rule out AIH and liver biopsy may be required to confirm the diagnosis. Seronegative AIH rapidly progresses to advanced liver disease. Response to treatment is good with pre-treatment IgG > 20g/L and post-treatment total bilirubin < 2 mg/dL.
Seroprevalence of antibodies against Anaplasma phagocytophilum and Borrelia burgdorferi in horses (Equus caballus) from northern Algeria
Authors: Laamari Abdelouahab , Azzag Naouelle , Tennah Safia , Derdour Salima-Yamina , China Bernard , Bouabdallah Ryhan , Ghalmi Farida 
Published: July 2020

Abstract

Introduction
Horses (Equus caballus) are susceptible to tick-borne diseases. Two of them, Lyme borreliosis due to Borrelia burgdorferi and granulocytic anaplasmosis due to Anaplasma phagocytophilum were investigated in Algerian horses. The diseases have been less extensively studied in horses and results pertinent to Algeria have not been published.

Material and Methods
Blood samples were obtained from 128 horses. IgG antibodies directed against Anaplasma phagocytophilum and Borrelia burgdorferi were detected by an indirect immunofluorescence antibody test (IFAT) and ELISA. The potential effects of age, gender, breed, and health status on seropositivity were also evaluated.

Results
Using IFAT, 28 (21.8%) and 25 (19.5%) animals were positive for B. burgdorferi and A. phagocytophilum, respectively. Using ELISA, 19 (14.8%) and 33 (25.9%) animals were positive for these bacteria.

Conclusion
The study shows that horses in Algeria are exposed or co-exposed to tick-transmitted zoonotic bacterial species.
Detection of myxoma virus in the classical form of myxomatosis using an AGID assay: statistical assessment of the assay’s diagnostic performance
Authors: Kwit Ewa , Osiński Zbigniew , Lavazza Antonio , Rzeżutka Artur 
Published: July 2020

Abstract

Introduction
The aim of the study was to estimate the diagnostic sensitivity (DSe) and specificity (DSp) of an agar gel immunodiffusion (AGID) assay for detection of myxoma virus (MYXV) in the classical form of myxomatosis and to compare its diagnostic performance to that of molecular methods (IAC-PCR, OIE PCR, and OIE real-time PCR).

Material and Methods
A panel of MYXV-positive samples of tissue homogenates with low (1 PCR unit – PCRU) and high (3,125 PCRU) virus levels and outbreak samples were used for method comparison studies. The validation parameters of the AGID assay were assessed using statistical methods.

Results
The AGID attained DSe of 0.65 (CI95%: 0.53–0.76), DSp of 1.00 (CI95%: 0.40–1.00), and accuracy of 0.67 (CI95%: 0.55–0.76). The assay confirmed its diagnostic usefulness primarily for testing samples containing ≥3,125 PCRU of MYXV DNA. However, in the assaying of samples containing <3,125 PCRU of the virus there was a higher probability of getting false negative results, and only molecular methods showed a 100% sensitivity for samples with low (1 PCRU) virus concentration. The overall concordance of the results between AGID and IAC-PCR was fair (ĸ = 0.40). Full concordance of the results was observed for OIE PCR and OIE real-time PCR when control reference material was analysed.

Conclusions
Findings from this study suggest that AGID can be used with some limitations as a screening tool for detection of MYXV infections.
Genetic diversity and structure of Oriental and European beech populations from Iran and Europe
Authors: Bijarpasi Mahboobeh Mohebi , Müller Markus , Gailing Oliver 
Published: July 2020

Abstract
Genetic variation is a major component of plant development and adaptation, and recent studies have shown that genetic variation among plant species can have important ecological effects. Oriental beech (Fagus orientalis Lipsky) is a dominant tree species in the Hyrcanian forests, where it occupies approximately 18 % of the forested area. In this study, nine expressed sequence tag simple sequence repeat (EST-SSR) markers were used to determine the genetic diversity and structure of Iranian Oriental beech populations growing at different altitudes. We further compared the genetic structures of the Iranian populations to a F. orientalis and a Fagus sylvatica L. population from the hybrid zone of the two taxa in southeast Europe, and to a F. sylvatica population from central Europe. All populations showed a high genetic diversity, which was similar to other F. orientalis and F. sylvatica populations from Europe. The genetic differentiation among Iranian beech populations was very low. In contrast, distinct genetic differentiation was found between the Iranian populations and the analyzed European populations (F. orientalis and F. sylvatica). One EST-SSR was identified to differentiate (GST
: 0.503) between F. orientalis and F. sylvatica with very pronounced allele frequency differences between taxa. Specifically, the Fagus sylvatica characteristic allele 189 was almost absent from all Iranian populations and present in low frequencies in F. orientalis populations from other regions. This study helps to extend the knowledge of genetic diversity and genetic structure of Iranian Oriental beech populations. It further gives insights into the genetic differentiation between F. orientalis populations from the center and the edge of the species’ distribution range as well as between Oriental and European beech.
Marker-assisted selection in C. oleifera hybrid population
Authors: Feng Jin-Ling , Jiang Ying , Yang Zhi-Jian , Chen Shi-Pin , El-Kassaby Yousry A. , Chen Hui 
Published: July 2020

Abstract
Marker-assisted selection (MAS) is implemented to improve Camellia oleifera yield and fruit attributes for meeting China’s increased demand for new varieties development. We conducted three-generational (G0, G1, and G2) hybridization (diallel mating) and selection experiment and used Sequence-Related Amplified Polymorphism (SRAP). SRAP markers to investigate their utility in a MAS framework. The utilized SRAP markers were instrumental in hybrid authenticity and the identification of matroclinal or patroclinal inheritance presence, thus guiding mating pair selection and direction (their role as male or females). Across the studied 3 generations, estimates of genetic diversity parameters showed steady increase with percentage increase of ((G0 to G1 and G1 to G2) 9.25 and 9.05: observed number of alleles; 3.12 and 7.80: means effective number of alleles; 12.35 and 22.34: Nei‘s gene diversity; and 14.21 and 21.77: Shannon‘s index), indicating lack of diversity reduction associated with selection. Estimates of genetic distance and their correlation with heterosis were useful in guiding selection of mating pairs for achieving the desired yield and fruit attributes (fruit diameter, height, weight, and index, peel thickness, number of seeds per fruit, seed weight per fruit, and seed rate). Most yield and fruit attributes exhibited high broad-sense heritability with increasing trend over generation intervals, indicating the increased potential of hybrid breeding for this species.
Policies of European Union countries towards the issue of illegal immigration
Authors: Abdul Karim Mohammad Zuhair 
Published: July 2020

Migration is an inherent phenomenon of human societies. It is the movement of people from a place where it is difficult to live to a better place, for socio-political reasons. Migration is either internal within one country or international between countries, And the latter may be legitimate or illegal. The European continent has become a dream for immigrants to live better. But Europe, which has received large numbers of immigrants and has become part of its social, economic and political entity, is beginning to suffer from problems and reflections: security, economic, social and political, in light of the increasing number of immigrants in Europe, which has made European countries since the 1980s changed their policies, And start to legislate laws and procedures and conclude restrictive immigration agreements, leading to the events of September 11, 2001, which made European policies more stringent towards immigration, to develop those policies after the Arab Renaissance revolutions in 2011, And what that left, waves of displaced people headed to Europe, thousands of them were received, but as a result of economic difficulties and security and political conditions that some European countries were exposed to, Some European calls have emerged to curb immigration, In light of the differences between the EU countries and the absence of a unified European policy and vision towards immigration, Nevertheless, European countries have formed some partnerships and agreements to combat migration, as well as conducting a set of collective and unilateral restrictive immigration procedures which have led to a reduction in the number of refugees to Europe.
Peacebuilding requirements in post-conflict societies
Authors: Al-Dabagh Zyad Samir 
Published: July 2020

The process of building peace and laying its foundations within the societies of the world, especially those newly emerging from the stage of conflict, are among the important and indispensable matters. Without peace, opportunities diminish in obtaining the essentials of a safe and normal life, and without peace, societies cannot It works and advances towards a better future.
However, peacebuilding operations in many societies emerging from conflict or those in which they live may face a set of challenges and obstacles that constitute a major obstacle to them, which necessitates searching for the best ways and means by which these obstacles can be addressed in order to build a real and effective peace that is reflected Positively on the people of those societies.
Mechanisms of Drug Solubilization by Polar Lipids in Biorelevant Media
Authors: Katev Vladimir , Vinarov Zahari , Tcholakova Slavka S. 
Published: July 2020

Despite the widespread use of lipid excipients in both academic research and oral formulation development, rational selection guidelines are still missing. In the current study, we aimed to establish a link between the molecular structure of commonly used polar lipids and drug solubilization in biorelevant media. We studied the effect of 26 polar lipids of the fatty acid, phospholipid or monoglyceride type on the solubilization of fenofibrate in a two-stage in vitro GI tract model. The main trends were checked also with progesterone and danazol.Based on their fenofibrate solubilization efficiency, the polar lipids can be grouped in 3 main classes. Class 1 substances (n = 5) provide biggest enhancement of drug solubilization (>10-fold) and are composed only by unsaturated compounds. Class 2 materials (n = 10) have an intermediate effect (3-10 fold increase) and are composed primarily (80 %) of saturated compounds. Class 3 materials (n = 11) have very low or no effect on drug solubilization and are entirely composed of saturated compounds.The observed behaviour of the polar lipids was rationalized by using two classical physicochemical parameters: the acyl chain phase transition temperature (Tm) and the critical micellar concentration (CMC). Hence, the superior performance of class 1 polar lipids was explained by the double bonds in their acyl chains, which: (1) significantly decrease Tm, allowing these C18 lipids to form colloidal aggregates and (2) prevent tight packing of the molecules in the aggregates, resulting in bigger volume available for drug solubilization. Long-chain (C18) saturated polar lipids had no significant effect on drug solubilization because their Tm was much higher than the temperature of the experiment (T = 37 C) and, therefore, their association in colloidal aggregates was limited. On the other end of the spectrum, the short chain octanoic acid manifested a high CMC (50 mM), which had to be exceeded in order to enhance drug solubilization. When these two parameters were satisfied (C > CMC, Tm < Texp), the increase of the polar lipid chain length increased the drug solubilization capacity (similarly to classical surfactants), due to the decreased CMC and bigger volume available for solubilization.The hydrophilic head group also has a dramatic impact on the drug solubilization enhancement, with polar lipids performance decreasing in the order: choline phospholipids > monoglycerides > fatty acids.As both the acyl chain length and the head group type are structural features of the polar lipids, and not of the solubilized drugs, the impact of Tm and CMC on solubilization by polar lipids should hold true for a wide variety of hydrophobic molecules. The obtained mechanistic insights can guide rational drug formulation development and thus support modern drug discovery pipelines.
Gambaran Status Kesehatan Gigi dan Mulut pada Pasien Prolanis di Puskesmas Kedungmundu
Authors: Soni Zazkia Zita Zhafira , Kusniati Retno , Rakhmawati Ayu Kristin 
Published: July 2020

Latar Belakang: Kesehatan gigi dan mulut masih menjadi permasalahan di masyarakat yang perlu diperhatikan. Prevalensi penduduk yang mempunyai masalah gigi dan mulut di Indonesia menurut Riskesdas 2018 sebesar 57,6%. PROLANIS (Program Pengelolaan Penyakit Kronis) merupakan suatu program dengan dua fokus penyakit yaitu Diabetes Melitus dan Hipertensi. Kasus Diabetes Melitus tertinggi di Kota Semarang tahun 2018 ada di Puskesmas Kedungmundu sebanyak 3.165 kasus dan Hipertensi sebanyak 4.417 kasus. Penderita Diabetes Melitus mempunyai beberapa manifestasi oral seperti karies, mulut kering, dan periodontitis. Sedangkan Hipertensi mempunyai manifestasi oral seperti hyperplasia gingival dan xerostomia. Tujuan penelitian ini adalah mendeskripsikan status kesehatan gigi dan mulut pada pasien Prolanis di Puskesmas Kedungmundu.Metode: Jenis penelitian deskriptif dengan pendekatan cross sectional, menggunakan teknik purposive sampling diperoleh 55 responden.Hasil: Keadaan mahkota gigi karies sebesar 38,6%, akar gigi karies sebesar 34,8%, gingival bleeding atau perdarahan gingiva sebesar 47,8%, poket periodontal 4-5 mm sebesar 75,1%, kehilangan perlekatan yaitu 0-3 mm, tidak ada tanda erosi sebesar 54%, tidak ada lesi mukosa oral sebesar 50,9%, kebutuhan perawatan segera sebesar 72,7%, dan hanya satu pasien yang menggunakan gigi tiruan.Kesimpulan: Pasien Prolanis di Puskesmas Kedungmundu mempunyai status kesehatan gigi dan mulut mahkota dan akar gigi yang karies, terdapat gingival bleeding atau perdarahan gingiva, terdapat poket periodontal dan kehilangan perlekatan, tidak ada tanda erosi gigi dan lesi mukosa oral, kebutuhan perawatan perlu tetapi tidak segera, dan hanya satu pasien yang menggunakan gigi tiruan.
Hubungan Manajemen Performa Kinerja Dosen Terhadap Hasil Belajar Mahasiswa FKG Unimus
Authors: Sholekhah Nur Khamilatusy 
Published: July 2020

Latar Belakang: Untuk meningkatkan mutu pendidikan, seorang pendidik diwajibkan memiliki keterampilan dasar yang baik sebagai penunjang pembelajaran.. Profesi dosen adalah pendidik profesional yang dituntut memiliki kinerja dalam bidang pengajaran dan pendidikan, penelitian serta melakukan pengabdian ke masyarakat secara luas dan mendalam. Penelitian ini bertujuan untuk mengetahui pengaruh performa kinerja dosen terhadap hasil belajar mahasiswa FKG UNIMUS.Metode: Penelitian ini menggunakan jenis penelitian deskriptif kuantitatif dimana kesimpulan ditarik melalui analisis statistik. Populasi dan sampel dalam penelitian ini adalah mahasiswa Program Studi Pendidikan Dokter Gigi UNIMUS angkatan 2017 yang berjumlah 48 mahasiswa. Teknik pengumpulan data yang dilaksanakan dalam penelitian menggunakan metode angket dan metode dokumentasi. Metode analisis data pada penelitian ini menggunakan software SmartPLS versi 2.0.m3 yang dijalankan dengan media komputer.Hasil: Berdasarkan hasil penelitian didapatkan hasil bahwa performa kinerja dosen berpengaruh positif dan signifikan terhadap hasil belajar mahasiswa karena nilai tstatistik lebih besar dari ttabel (tstatistik 14,55 > ttabel 1,66) pada taraf signifikansi 5%.Kesimpulan: terdapat hubungan performa dosen yang dinilai dari 3 dimensi yaitu monitoring umum, pengajaran, dan materi terhadap hasil belajar ujian tertulis mahasiswa Fakultas Kedokteran Gigi Universitas Muhammadiyah Semarang di Blok Keterampilan Belajar dan Komunikasi tahun akademik 2017/2018.