bluuebunny/crossref_metadata_2025_split huggingface dataset:
UCP2 and CFH Gene Variants with Genetic Susceptibility to Schizophrenia in Turkish Population
Authors: Nursal Ayse Feyda , Aydin Pinar Cetinay , Pehlivan Mustafa , Sever Ulgen , Pehlivan Sacide 
Published: November 2020

Objective:
Schizophrenia (Sch) is a complex, multifactorial psychiatric disorder. Growing evidence shows that
oxidative damage and immunological dysfunction exist in the Sch physiopathology. In the present study, we aimed to evaluate
whether the Uncoupling protein 2 and Complement factor H gene variants play any role in susceptibility to Sch.

Methods:
This study was carried out on 200 individuals (100 Sch patients and 100 healthy controls). Genomic DNA was extracted
from blood samples.UCP2-866G /A (rs659366) and CFHY402H variants were analyzed by PCR-RFLP analysis.

Results:
The UCP2 -866G/A variant G/G genotype and G allele were associated significantly with increased risk of Sch
(p=0.001, p=0.001, respectively). The subjects carrying UCP2 -866G/A variant G/G genotype had 4.377-fold increased risk
for Sch.There was no significant difference between the groups for the genotype and allele frequencies of CFH Y402H variant
(p>0.05). The observed genotype counts deviated significantly from those expected in Sch patients according to the
HWE for UCP2 -866G/A variant (p=0.001).

Conclusion:
We present the first results investigating UCP2 -866G/A/ and CFH Y402H variants for susceptibility to Sch in
a Turkish population. These results indicate that the UCP2 -866G/A, but not CFH Y402H variant, might play an important
role in the development of Sch.
User authentication based on the three-stage keyboarding model
Authors: Abzalov A. R. , Kashapov I. I. , Orlov A. Yu. , Mamleev I. R. 
Published: November 2020

Objective. The article offers a three-stage model that allows increasing the effectiveness of authentication in the implementation of distance learning systems, not only in automatic proctoring systems but also in complex information systems of critical objects. Methods. Increasing the effectiveness of user authentication is achieved by increasing the accuracy of authentication using keyboarding. Results. The proposed model will help to implement the process of access differentiation for fraudsters and legal users, by adapting to the slightest changes in the keyboarding parameters, which allows increasing the authentication accuracy. During testing, one of the tested users was authenticated using a deviation comparison, while the other three users were authenticated using the χ2 criterion. The remaining users were not able to complete the authentication procedure at all stages of the system. Conclusion. The results of an experimental study showed the high ability of the proposed model of access control for legitimate users and attackers with some minor changes in the parameters of the keystrokes dynamics, improving the accuracy of user authentication. The user authentication reliability in practice was 97.5%.
Using Character-Level and Entity-Level Representations to Enhance Bidirectional Encoder Representation From Transformers-Based Clinical Semantic Textual Similarity Model: ClinicalSTS Modeling Study
Authors: Xiong Ying , Chen Shuai , Chen Qingcai , Yan Jun , Tang Buzhou 
Published: November 2020

Background
With the popularity of electronic health records (EHRs), the quality of health care has been improved. However, there are also some problems caused by EHRs, such as the growing use of copy-and-paste and templates, resulting in EHRs of low quality in content. In order to minimize data redundancy in different documents, Harvard Medical School and Mayo Clinic organized a national natural language processing (NLP) clinical challenge (n2c2) on clinical semantic textual similarity (ClinicalSTS) in 2019. The task of this challenge is to compute the semantic similarity among clinical text snippets.

Objective
In this study, we aim to investigate novel methods to model ClinicalSTS and analyze the results.

Methods
We propose a semantically enhanced text matching model for the 2019 n2c2/Open Health NLP (OHNLP) challenge on ClinicalSTS. The model includes 3 representation modules to encode clinical text snippet pairs at different levels: (1) character-level representation module based on convolutional neural network (CNN) to tackle the out-of-vocabulary problem in NLP; (2) sentence-level representation module that adopts a pretrained language model bidirectional encoder representation from transformers (BERT) to encode clinical text snippet pairs; and (3) entity-level representation module to model clinical entity information in clinical text snippets. In the case of entity-level representation, we compare 2 methods. One encodes entities by the entity-type label sequence corresponding to text snippet (called entity I), whereas the other encodes entities by their representation in MeSH, a knowledge graph in the medical domain (called entity II).

Results
We conduct experiments on the ClinicalSTS corpus of the 2019 n2c2/OHNLP challenge for model performance evaluation. The model only using BERT for text snippet pair encoding achieved a Pearson correlation coefficient (PCC) of 0.848. When character-level representation and entity-level representation are individually added into our model, the PCC increased to 0.857 and 0.854 (entity I)/0.859 (entity II), respectively. When both character-level representation and entity-level representation are added into our model, the PCC further increased to 0.861 (entity I) and 0.868 (entity II).

Conclusions
Experimental results show that both character-level information and entity-level information can effectively enhance the BERT-based STS model.
Preparing for Audit Data Analytics with the AICPA General Ledger Audit Data Standards
Authors: Lee Lorraine S. , Casterella Gretchen , Wray Barry 
Published: November 2020

ABSTRACT
It is challenging for auditors to effectively and efficiently use data analytics in audit procedures and general ledger testing when the data acquired from clients is often incomplete and not in a usable format. Considerable time must be spent cleansing, transforming, standardizing, and validating the data prior to analyzing it. This problem motivated the AICPA task force to develop a set of Audit Data Standards (ADS) for streamlining the exchange of data. This paper describes an extensive exercise where students: (1) develop a Microsoft Access database that complies with the ADS for general ledger data; (2) cleanse and transform non-standardized client data for import into an ADS-compliant database; and (3) write queries for general ledger testing and journal entry testing. The exercise strengthens students' database and query-writing skills, while introducing the ADS in the context of realistic tasks to support a financial statement audit.
Not So Fuzzy Auditing Analytics
Authors: Hoelscher Jamie L. , Shonhiwa Trevor 
Published: November 2020

ABSTRACT
In light of the increased emphasis on data analytics by accounting practitioners and accreditation bodies, the objective of this paper is to present a case that will help increase students' understanding of textual analytics, which is an under-researched area of data analytics (Fisher 2018). Specifically, students will use both conditional formatting and the fuzzy lookup tool to examine a dataset for possible instances of fictitious vendor fraud, a common and often costly type of fraud. The case takes students through the comprehensive data analytics cycle. First, students are instructed how to test for fictitious vendors by using data analytic techniques. Students will then rely on the underlying data to analyze potential relationships and trends. In the final step, students will communicate results via a memorandum.
Knowledge of Cervical Cancer and Its Screening Amongst Female Students of a Tertiary Institution in South-South Nigeria
Authors: Allagoa D. O. , Agbo O. J. , Eguvbe A. O. , Alabrah P. W. 
Published: November 2020

Background: Cervical cancer is one of the commonest cancers in women. It is the commonest cause of cancer related death in Africa. It is one of the cancers that have well known screening methods. In developed societies with standard protocol for screening, the morbidity and mortality following the disease have been greatly reduced. There is paucity of knowledge of cervical cancer and its screening methods in Yenagoa.
Objectives: To determine the knowledge of cervical cancer and its screening methods in female students of a Tertiary educational institution.
Methods: This was a cross-sectional descriptive study that was conducted amongst the female students of Federal University Otuoke. Information about their socio-demographic characteristics, knowledge of cervical cancer and the screening methods was obtained using a questionnaire.
Results: A total of four hundred and twenty four (424) female students of the Federal University Otuoke were enrolled for the study. The mean age of the respondents was 21.0±3.4 years. The predominant age group was 15-20 years (50.6%). One hundred and eighty three respondents (57.9%) were aware of cervical cancer and the age groups 21-25 years were most aware of cervical cancer. Age was found to influence awareness of cervical cancer. (x2=12.8; df=3; p<0.05). A total of eighty one respondents 26.9% were aware of Pap smear. Age was found to influence the awareness of Pap smear (x2=12.8; df=3; p<0.05).
Conclusion: Our study showed that awareness of cervical cancer and the role of Pap smear in the screening of cervical cancer was low amongst the female students of the Federal University Otuoke. Hence the need to make every effort to increase the awareness of this condition and the screening methods amongst these female undergraduates, who are at the prime of their age and at the greatest risk of developing this condition, especially in our societies that lack well organized screening protocols.
Syncope: A Very Atypical Presentation of COVID-19
Authors: Shih Richard D. , Louis Paul M. , Alter Scott M. , Hughes Patrick G. , Solano Joshua J. , Clayton Lisa M. 
Published: November 2020

Possible COVID-19 patients have presented commonly to United States Emergency Departments. Patients presenting with cough, fever and shortness of breath are easy to identify as suspected cases. Unfortunately, not all COVID-19 patients present this way. Atypical presentations are a risk factor for healthcare worker (HCW) transmission of this disease. In this case report we describe the unusual case of COVID-19 presenting as syncope without any other risk factors. HCWs need to be aware of atypical COVID-19 presentations and to maintain proper use of personal protective equipment.
Hubungan Dukungan Suami terhadap Kelengkapan Kunjungan ANC di Puskesmas Lubuk Buaya
Authors: De Laila Inge , Burhan Ida Rahman , Handayani Tuti 
Published: November 2020

Melakukan kunjungan ANC sesuai standar merupakan salah satu cara untuk meningkatkan status kesehatan ibu hamil dalam rangka menurunkan angka kematian ibu di Indonesia. Cakupan ANC di Puskesmas Lubuk Buaya yang belum mencapai target dalam dua tahun terakhir, menggambarkan bahwa masih ada ibu hamil yang tidak melakukan kunjungan ANC sesuai standar. Keterlibatan suami selama kehamilan dapat menjadi faktor pendorong untuk memeriksakan kehamilan. Penelitian ini adalah penelitian analitik menggunakan desain cross sectional dan dianalisis dengan menggunakan uji chi-square. Teknik pengambilan sampel yang digunakan dalam penelitian ini adalah consecutive sampling dengan jumlah sampel sebanyak tiga puluh enam orang ibu hamil yang berkunjung ke Puskesmas Lubuk Buaya dari bulan Januari 2019 - Februari 2019 dengan usia kandungan ≥ tiga puluh enam minggu. Data diambil menggunakan kuesioner untuk menilai dukungan suami. Sebanyak 52.8% ibu hamil melakukan ANC lengkap sesuai standar (K4). Dukungan suami baik pada ibu hamil ditemukan sebanyak 61.1 % dari total responden Berdasarkan dari hasil penelitian terdapat hubungan antara dukungan suami dengan kelengkapan kunjungan ANC (=0.003). Adanya hubungan yang signfikan antara dukungan suami dengan kelengkapan kunjungan ANC. Untuk itu tenaga kesehatan perlu memberikan informasi dan pendidikan tentang kesehatan ibu hamil tidak hanya kepada ibu hamil tetapi juga kepada suaminya.
Kata kunci: Kunjungan ANC, K4, Dukungan Suami
Pengaruh Pemberian Ekstrak Ubi Jalar Ungu terhadap Kadar Glukosa Darah dan MDA Hepar Tikus Hiperglikemia
Authors: Pratiwi Annisa , Alioes Yustini , Aprilia Dinda 
Published: November 2020

Latar Belakang. Ubi jalar ungu mengandung senyawa antioksidan berupa antosianin, asam fenolat, vitamin A, C, dan E. Antioksidan dapat meredam kerusakan oksidatif pada sel beta pankreas sehingga mampu meningkatkan sekresi insulin serta mengurangi stres oksidatif pada DM.
Objektif. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak ubi jalar ungu terhadap kadar glukosa darah dan MDA hepar tikus hiperglikemia.
Metode. Penelitian ini merupakan true experimental dengan post-test only control group design. Sebanyak 24 ekor tikus dibagi menjadi empat kelompok, yaitu kontrol negatif (K-), kontrol positif (K+), perlakuan satu (P1), dan perlakuan dua (P2). Kelompok P1 dan P2 diinduksi aloksan dan diberikan ekstrak ubi jalar ungu dosis 150 mg/kgBB dan 200 mg/kgBB selama 21 hari.
Hasil. Terdapat perbedaan signifikan kadar glukosa darah antara kelompok P1 dan P2 dengan kelompok K+ dengan nilai p = 0,000. Terdapat perbedaan signifikan kadar MDA hepar antara kelompok P1 dibandingkan K- dan K+ dengan nilai p = 0,001 dan p = 0,046, kelompok P2 dibandingkan K- dan K+ dengan nilai p = 0,037 dan p = 0,001.
Kesimpulan. Ekstrak ubi jalar ungu berpengaruh dalam menurunkan kadar glukosa darah dan MDA hepar tikus hiperglikemia.
Kata kunci: ubi jalar ungu, glukosa darah, MDA hepar

Background. Purple sweet potato contains antioxidant compounds such as anthocyanin, phenolic acid, vitamin A, C, and E. Antioxidants can reduce oxidative damaged of mitochondria in pancreatic beta cell resulting an increase in insulin secretion and a decrease oxidative stress in DM patients.
Objective. This study aimed to determine the effect of giving purple sweet potato extract on blood glucose levels and liver MDA in hyperglycemic rats.
Methods. This study was true experimental with post-test only control group design. A total of 24 rats were divided into 4 groups, namely negative control (K-), positive control (K+), treatment one (P1), and treatment two (P2). P1 and P2 group were induced by alloxan and given purple sweet potato extract dose of 150 mg/kgBB and 200 mg/kgBB for 21 days.
Result. There were significant differences between P1 and P2 with K+ group with p value = 0,000. There were significant difference between P1 group with the K- and K+ group with p value = 0.001 and 0,046, P2 compared to K- and K+ group with p value = 0.037 and p = 0,001.
Conclusion. Purple sweet potato extract can reduce the level of blood glucose level and MDA in liver tissues.
Karakteristik Kasus Kematian dengan Temuan Cedera Kepala Periode 2018 - 2019
Authors: Mudzakir Muhammad Tsani , Susanti Rika , Noverial Noverial 
Published: November 2020

Cedera kepala adalah suatu kerusakan pada kepala, bukan bersifat kongenital ataupun degeneratif, tetapi disebabkan oleh serangan atau benturan fisik dari luar, yang dapat menyebabkan gangguan pada kemampuan kognitif dan fungsi fisik.Cedera kepala masih menjadi penyebab utama morbiditas dan mortalitas pada populasi dunia berumur dibawah 45 tahun. Penelitian ini bertujuan untuk mengetahui karakteristik kematian dengan temuan cedera kepala di Rumah Sakit Umum Pendidikan Dr. M. Djamil Padang tahun 2018 – 2019.
Penelitian ini merupakan penelitian deskriptif retrospektif dengan desain cross sectional menggunakan data sekunder terhadap 121 kasus kematian dengan temuan cedera kepala yang memenuhi kriteria inklusi di RSUP Dr. M.Djamil Padang tahun 2018 – 2019. Dengan metode pengambilan sampel menggunakan teknik total sampling.
Hasil penelitian didapatkan 121 kasus kematian dengan temuan cedera kepala yang memenuhi kriteria inklusi. Jenis kelamin terbanyak adalah laki-laki (72,7%), terjadi terutama pada kelompok usia 18 hingga 65 tahun (62,8%). Kategori pekerjaan dengan kasus terbanyak adalah pelajar (26,5%). Penyebab paling umum dari cedera kepala adalah kecelakaan lalulintas (88,4%). Lokasi kematian terbanyak terjadi di rumah sakit (89,3%).
Prevalensi Nyeri Tenggorok Pascaoperasi dengan Pemberian Lubrikasi VCO pada Pemasangan LMA
Authors: Rianti Rahmadhya Khairina , Kurnia Dedy , Afdal Afdal 
Published: November 2020

Background. Postoperative sore throat (POST) is a common complication after general anaesthesia. It affects patient satisfaction and can affect activity after discharge. The supraglottic airway device (SAD) offers an alternative to traditional tracheal intubation with potential benefit in preventing sore throat. Numerous agents have been used as lubricant to reduce the incidence of POST with variable efficacy. The purpose of this study is to determine the prevalence of postoperative sore throat in patients with Virgin Coconut Oil (VCO) as a lubricant for Laryngeal Mask Airway (LMA) insertion in patients undergoing general anaesthesia for elective surgery.
Objective. Determine the prevalence of postoperative sore throat in patients by giving Virgin Coconut Oil (VCO) as a lubricant for the Laryngeal Mask Airway (LMA) installation under general anesthesia for elective surgery.
Methods. This is an observational descriptive study, was conducted in December 2019 until June 2020 at Surgical Installation RSUP dr. M. Djamil Padang and Andalas University Hospital. Forty-two subjects were recruited to this study taken by using consecutive sampling technique.
Results. Patients evaluated about sore throat at immediately, 2 hours, and 24 hours post-operative period. POST was observed in 47,6% of the patients in immediate post-operative period. After 2 hours 23,8% patients had sore-throat, and after 24 hours 9,5% patients had sore-throat. Among patients had sore throat after 24 hours, the intensity was mild.
Conclusion. We conclude that lubricating cuff of LMA with VCO can reduce the prevalence of POST.
Keyword: Laryngeal Mask Airway, sore throat, Virgin Coconut Oil
Hubungan ASI Eksklusif dan Riwayat ISPA Terhadap Kolonisasi Streptococcus pneumoniae pada Swab Nasofaring Anak Bawah Dua Tahun
Authors: Rani Indri Permata , Yani Finny Fitry 
Published: November 2020

Pneumonia merupakan penyebab kematian utama pada anak di dunia. Streptococcus pneumoniae (S. pneumoniae) sebagai bakteri terbanyak penyebab pneumonia dapat membentuk kolonisasi di nasofaring anak. Faktor yang mempengaruhi kolonisasi S. pneumoniae ini diantaranya adalah pemberian air susu ibu (ASI) ekslusif dan infeksi saluran pernafasan akut (ISPA) pada anak. Penelitian ini bertujuan untuk mengetahui hubungan pemberian ASI ekslusif dan riwayat ISPA terhadap kolonisasi S. pneumoniae pada swab nasofaring anak usia bawah dua tahun. Penelitian ini merupakan studi analitik dengan metode cross sectional pada 30 orang anak usia bawah dua tahun. Data mengenai pemberian ASI eksklusif dan riwayat ISPA didapatkan dari hasil wawancara langsung pada saat pengambilan swab nasofaring anak. Analisis data menggunakan uji chi square. Hasil yang didapatkan pada penelitian ini sebanyak 63,3% dari anak usia bawah dua tahun ditemukan adanya kolonisasi S. pneumoniae dari hasil swab nasofaring. Hasil analisis data menggunakan chi square diperoleh nilai p=0,637 untuk hubungan pemberian ASI eksklusif terhadap kolonisasi S. pneumoniae, dan hubungan riwayat ISPA terhadap kolonisasi S. pneumoniae nilai p=0,245. Kesimpulan dari penelitian ini tidak terdapat hubungan yang bermakna antara pemberian ASI eksklusif dan riwayat ISPA terhadap kolonisasi S. pnuemoniae pada swab nasofaring anak usia bawah dua tahun
Hubungan antara Tingkat Stres dengan Dismenore Primer pada Mahasiswi Tahun Pertama Program Studi Kedokteran Angkatan 2018 Fakultas Kedokteran
Authors: Sriwati Almira Rosyidika , Ermawati Ermawati , Isrona Laila 
Published: November 2020

Abstrak
Dismenore primer merupakan keluhan ginekologis yang sering terjadi pada remaja di dunia. Dismenore primer akan berdampak pada kualitas hidup, dapat menurunkan konsentrasi belajar seseorang karena nyeri yang dirasakan. Salah satu faktor risiko dismenore primer adalah stres. Penelitian ini dilakukan untuk mengetahui hubungan antara tingkat stres dengan dismenore primer pada mahasiswi tahun pertama program studi kedokteran angkatan 2018 Fakultas Kedokteran Universitas Andalas. Desain penelitian yang digunakan adalah cross sectional dengan teknik total sampling dengan jumlah sampel 146 orang. Data responden diperoleh dari kuisioner. Data dianalisis menggunakan uji Fhiser. Hasil penelitian menunjukan lebih dari separuh responden tidak stres (65,1 %) dan tidak dismenore primer (93, 8%). Hasil analisis bivariat menunjukan tidak terdapat hubungan antara tingkat stres dengan dismenore primer dengan p=0,720 (p> 0,05). Kesimpulan penelitian ini adalah sebagian besar mahasiswi tahun pertama tidak mengalami dismenore primer dan tidak stres. Tidak terdapat hubungan antara tingkat stres dengan dismenore primer.
kunci : stres, dismenore primer, mahasiswi tahun pertama.

Abstract
Primary dysmenorrhea is a gynecological complaint that often occurs in adolescents in the world. Primary dysmenorrhea will have an impact on quality of life, can reduce the concentration of learning because of the pain. One of the risk factor for primary dysmenorrhea is stress. This study was conducted to determine the relationship between stress levels and primary dysmenorrhea in the first year female medical students of the 2018 registered year at Medical Faculty of Andalas University.Cross-sectional study design with total sampling technique was used with 146 people of total sample. Respondents's data were obtained from questionnaires. Data were analyzed by using the Fhiser test. The results showed that more than half of the respondents were not stressed (65.1 %) and neither have primary dysmenorrhea (93.8%). The results of bivariate analysis showed that there was no correlation between stress levels and primary dysmenorrhea with p = 0.720 (p> 0.05). The conclusion of this study is most of the first year female medical did not experience primary dysmenorrhea and were not stressed. There are no relationship between stress levels with primary dysmenorrhea.
Keywords : stress, primary dysmenorrhea, first year female students