bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent developments of advanced micro-supercapacitors: design, fabrication and applications
Authors: Bu Fan , Zhou Weiwei , Xu Yihan , Du Yu , Guan Cao , Huang Wei 
Published: November 2020

AbstractThe rapid development of wearable, highly integrated, and flexible electronics has stimulated great demand for on-chip and miniaturized energy storage devices. By virtue of their high power density and long cycle life, micro-supercapacitors (MSCs), especially those with interdigital structures, have attracted considerable attention. In recent years, tremendous theoretical and experimental explorations have been carried out on the structures and electrode materials of MSCs, aiming to obtain better mechanical and electrochemical properties. The high-performance MSCs can be used in many fields, such as energy storage and medical assistant examination. Here, this review focuses on the recent progress of advanced MSCs in fabrication strategies, structural design, electrode materials design and function, and integrated applications, where typical examples are highlighted and analyzed. Furthermore, the current challenges and future development directions of advanced MSCs are also discussed.
Dogs accurately track a moving object on a screen and anticipate its destination
Authors: Völter Christoph J. , Karl Sabrina , Huber Ludwig 
Published: November 2020

AbstractThe prediction of upcoming events is of importance not only to humans and non-human primates but also to other animals that live in complex environments with lurking threats or moving prey. In this study, we examined motion tracking and anticipatory looking in dogs in two eye-tracking experiments. In Experiment 1, we presented pet dogs (N = 14) with a video depicting how two players threw a Frisbee back and forth multiple times. The horizontal movement of the Frisbee explained a substantial amount of variance of the dogs’ horizontal eye movements. With increasing duration of the video, the dogs looked at the catcher before the Frisbee arrived. In Experiment 2, we showed the dogs (N = 12) the same video recording. This time, however, we froze and rewound parts of the video to examine how the dogs would react to surprising events (i.e., the Frisbee hovering in midair and reversing its direction). The Frisbee again captured the dogs’ attention, particularly when the video was frozen and rewound for the first time. Additionally, the dogs looked faster at the catcher when the video moved forward compared to when it was rewound. We conclude that motion tracking and anticipatory looking paradigms provide promising tools for future cognitive research with canids.
Using a bio-scanner and 3D printing to create an innovative custom made approach for the management of complex entero-atmospheric fistulas
Authors: Durán Muñoz-Cruzado Virginia , Calero Castro Francisco José , Padillo Eguía Andrés , Tallón Aguilar Luis , Tinoco González José , Puyana Juan Carlos , Pareja Ciuró Felipe , Padillo-Ruiz Javier 
Published: November 2020

AbstractEnteroatmospheric fistulae are challenging clinical conditions that require surgical expertise and that can result in chronic debilitating conditions placing the patient in a vicious cycle characterized by non healing wounds and malnutrition. They are a complex entity that presents great variability depending on the number, shape, and size of the fistulous orifices, their debit, and the dimensions of the wound. This means that, at present, there is no device that adapts to the anatomical characteristics of each patient and manages to control the spillage of intestinal effluvium from the wound. The aim of this study is to describe the manufacturing technique and to assess the preliminary results of a custom device designed through bioscanner imaging and manufactured using 3D printing for use with negative pressure wound therapy (NPWT) in the management of enteroatmospheric fistula. A proof of concept is given, and the design of the device is presented for the first time. After obtaining images of each fistula with a bioscanner, a personalised device was designed for each patient by 3D printing shape of a prism and a hollow base, taking into account the dimensions of the fistulous area in order to perform a floating ostomy to isolate the wound from the debit enteric. The polycaprolactone (PCL) device was placed including inside the fistulous surface and surrounding it with the NPWT system in order to accelerate wound healing.
The ambiguity of nestedness under soft and hard constraints
Authors: Bruno Matteo , Saracco Fabio , Garlaschelli Diego , Tessone Claudio J. , Caldarelli Guido 
Published: November 2020

AbstractMany real networks feature the property of nestedness, i.e. the neighbours of nodes with a few connections are hierarchically nested within the neighbours of nodes with more connections. Despite the abstract simplicity of this notion, various mathematical definitions of nestedness have been proposed, sometimes giving contrasting results. Moreover, there is an ongoing debate on the statistical significance of nestedness, since random networks where the number of connections (degree) of each node is fixed to its empirical value are typically as nested as real ones. By using only ergodic and unbiased null models, we propose a clarification that exploits the recent finding that random networks where the degrees are enforced as hard constraints (microcanonical ensembles) are thermodynamically different from random networks where the degrees are enforced as soft constraints (canonical ensembles). Indeed, alternative definitions of nestedness can be negatively correlated in the microcanonical one, while being positively correlated in the canonical one. This result disentangles distinct notions of nestedness captured by different metrics and highlights the importance of making a principled choice between hard and soft constraints in null models of ecological networks.
Interoception is associated with the impact of eye contact on spontaneous facial mimicry
Authors: Imafuku Masahiro , Fukushima Hirokata , Nakamura Yuko , Myowa Masako , Koike Shinsuke 
Published: November 2020

AbstractInteroception (perception of one’s own physiological state) has been suggested to underpin social cognition, although the mechanisms underlying this association remain unclear. The current study aimed to elucidate the relationship between interoception and two factors underlying social cognition: self-other boundary and sensitivity to social cues. We measured performance in a heartbeat perception task as an index of interoceptive accuracy (IAc), the frequency of spontaneous facial mimicry (SFM) as an index of self-other boundary, and the degree of the effect of eye contact on SFM (difference in SFM between conditions in which models’ eyes were directed to and averted from participants) as an index of social-cue sensitivity, and tested correlations among these measures. The results revealed that IAc and SFM were positively correlated only in the direct gaze condition. The extent of the effect of eye contact on SFM (difference in frequency between direct vs. averted conditions) was positively correlated with IAc. These overall findings were also observed in separate analyses of male and female participant groups, supporting the robustness of the findings. The results suggest that interoception is related to sensitivity to social cues, and may also be related to the self-other boundary with modulation by social context.
Fusobacterium nucleatum in biopsied tissues from colorectal cancer patients and alcohol consumption in Korea
Authors: Kim Myungsook , Lee Seung-Tae , Choi Songyi , Lee Hyukmin , Kwon Sun Sung , Byun Jung Hyun , Kim Young Ah , Rhee Ki-Jong , Choi Jong Rak , Kim Tae Il , Lee Kyungwon 
Published: November 2020

AbstractThe roles of individual bacteria and their relationship in the development of colorectal cancer (CRC) remain unclear. We aimed to determine the prevalence of CRC-associated bacteria using quantitative real-time PCR (qPCR) or 16S rRNA analysis and the statistical correlations of patient demographics and clinical characteristics comprising alcohol consumption with CRC-associated bacteria. We determined the prevalence of five CRC-associated bacterial species in 38 CRC patients (39 samples) and 21 normal individuals using qPCR, and the relative abundance of bacterial taxa in the gut microbiome was assessed using 16S rRNA analysis. Fusobacterium nucleatum was the only bacterium that was significantly (P < 0.0001) more prevalent in the cancer tissue (82.1%) than in the normal tissue (0%) by qPCR. 16S rRNA analysis showed a significant correlation between six operational taxonomic units (OTUs), namely, the genera Fusobacterium, Peptostreptococcus, Collinsella, Prevotella, Parvimonas, and Gemella, in patients with CRC. An integrated analysis using 16S rRNA data and epidemiological characteristics showed that alcohol consumption was significantly correlated with the abundance of Fusobacterium OTUs. The correlation of alcohol consumption with the abundance of Fusobacterium OTUs in cancer tissue discovered using 16S rRNA analysis suggests a possible link between alcohol metabolism and subsequent tumorigenesis caused by F. nucleatum.
Development and in vitro validation of flexible intraretinal probes
Authors: Rincón Montes V. , Gehlen J. , Ingebrandt S. , Mokwa W. , Walter P. , Müller F. , Offenhäusser A. 
Published: November 2020

AbstractThe efforts to improve the treatment efficacy in blind patients with retinal degenerative diseases would greatly benefit from retinal activity feedback, which is lacking in current retinal implants. While the door for a bidirectional communication device that stimulates and records intraretinally has been opened by the recent use of silicon-based penetrating probes, the biological impact induced by the insertion of such rigid devices is still unknown. Here, we developed for the first time, flexible intraretinal probes and validated in vitro the acute biological insertion impact in mouse retinae compared to standard silicon-based probes. Our results show that probes based on flexible materials, such as polyimide and parylene-C, in combination with a narrow shank design 50 µm wide and 7 µm thick, and the use of insertion speeds as high as 187.5 µm/s will successfully penetrate the retina, reduce the footprint of the insertion to roughly 2 times the cross-section of the probe, and induce low dead cell counts, while keeping the vitality of the tissue and recording the neural activity at different depths.
Haptic human–human interaction does not improve individual visuomotor adaptation
Authors: Beckers Niek , van Asseldonk Edwin H. F. , van der Kooij Herman 
Published: November 2020

AbstractHaptic interaction between two humans, for example, a physiotherapist assisting a patient regaining the ability to grasp a cup, likely facilitates motor skill acquisition. Haptic human–human interaction has been shown to enhance individual performance improvement in a tracking task with a visuomotor rotation perturbation. These results are remarkable given that haptically assisting or guiding an individual rarely benefits their individual improvement when the assistance is removed. We, therefore, replicated a study that reported that haptic interaction between humans was beneficial for individual improvement for tracking a target in a visuomotor rotation perturbation. In addition, we tested the effect of more interaction time and a stronger haptic coupling between the partners on individual improvement in the same task. We found no benefits of haptic interaction on individual improvement compared to individuals who practised the task alone, independent of interaction time or interaction strength.
Uncovered self-expandable metal stents for the treatment of refractory benign colorectal anastomotic stricture
Authors: Hong Ji Taek , Kim Tae Jun , Hong Sung Noh , Kim Young-Ho , Chang Dong Kyung , Kim Eun Ran 
Published: November 2020

AbstractSelf-expandable metal stent (SEMS) placement has been suggested as a therapeutic modality for treating benign colorectal strictures. Covered stents are generally used, given the concerns regarding the efficacy and safety of uncovered stents. Hence, few studies have evaluated the efficacy and safety of uncovered SEMSs (UCSEMSs) in patients with refractory benign colorectal anastomotic strictures. In this study, 12 patients with postoperative benign symptomatic anastomotic strictures refractory to pneumatic dilation (range, 2–9) and transient indwelling-covered SEMSs were treated using UCSEMS. All enrolled patients were men (mean age, 61 years). Stent placement was successful in all 12 patients, and early clinical success was achieved in 11 (92%) patients. Four patients (25%) showed successful clinical outcomes without further intervention, but eight patients (75%) were clinically unsuccessful, and showed stricture recurrence or functional obstructive symptoms. Three patients underwent surgery, and the remaining five patients required repeat stent procedures. Despite the high reobstruction rate, the median follow-up period after UCSEMS placement was 16.7 months, demonstrating that UCSEMS may be able to achieve medium-term symptom relief without any complications. Therefore, UCSEMS may be an alternative option in exceptional circumstances in carefully selected patients, where invasive surgical treatments, such as stoma diversion, are not an option, thereby improving patients’ quality of life.
A meta-analysis of the effect of binge drinking on the oral microbiome and its relation to Alzheimer’s disease
Authors: Yussof Ayuni , Yoon Paul , Krkljes Cayley , Schweinberg Sarah , Cottrell Jessica , Chu Tinchun , Chang Sulie L. 
Published: November 2020

AbstractThe diversity of bacterial species in the oral cavity makes it a key site for research. The close proximity of the oral cavity to the brain and the blood brain barrier enhances the interest to study this site. Changes in the oral microbiome are linked to multiple systemic diseases. Alcohol is shown to cause a shift in the microbiome composition. This change, particularly in the oral cavity, may lead to neurological diseases. Alzheimer’s disease (AD) is a common neurodegenerative disorder that may cause irreversible memory loss. This study uses the meta-analysis method to establish the link between binge drinking, the oral microbiome and AD. The QIAGEN Ingenuity Pathway Analysis (IPA) shows that high levels of ethanol in binge drinkers cause a shift in the microbiome that leads to the development of AD through the activation of eIF2, regulation of eIF4 and p70S6K signaling, and mTOR signaling pathways. The pathways associated with both binge drinkers and AD are also analyzed. This study provides a foundation that shows how binge drinking and the oral microbiome dysbiosis lead to permeability changes in the blood brain barrier (BBB), which may eventually result in the pathogenesis of AD.
A theoretical design method for the nozzle pitch of air-flotation system to reduce large liquid crystal display glass substrate’s deformation
Authors: Huang Bin , Fu Teng , Xu Xiao-bo , Chen Mei-xian , Zhou Yang , Zhang Yong , Liu Shan-lin 
Published: November 2020

AbstractThe deformation of large glass substrate in air-flotation system affects detection accuracy of inspection instrument. According to the gas lubrication theory, Timoshenko’s thin film theory and the simulation figure of the pressure distribution of the air film flow field, the air load distribution model of the air film is established, and the deformation expression of the large liquid crystal glass substrate in air-flotation system is given. On this basis, a theoretical design method for designing nozzle pitch of orifice throttling air-flotation system was proposed. Combined with examples, the results of theories and simulation are compared. An experiment on the deformation of the glass substrate was carried out on an experimental prototype. The difference between the experimental results and the theoretical results does not exceed 10%.
Generating synthetic aging trajectories with a weighted network model using cross-sectional data
Authors: Farrell Spencer , Mitnitski Arnold , Rockwood Kenneth , Rutenberg Andrew 
Published: November 2020

AbstractWe develop a computational model of human aging that generates individual health trajectories with a set of observed health attributes. Our model consists of a network of interacting health attributes that stochastically damage with age to form health deficits, leading to eventual mortality. We train and test the model for two different cross-sectional observational aging studies that include simple binarized clinical indicators of health. In both studies, we find that cohorts of simulated individuals generated from the model resemble the observed cross-sectional data in both health characteristics and mortality. We can generate large numbers of synthetic individual aging trajectories with our weighted network model. Predicted average health trajectories and survival probabilities agree well with the observed data.
Cretaceous amniote integuments recorded through a taphonomic process unique to resins
Authors: Álvarez-Parra Sergio , Delclòs Xavier , Solórzano-Kraemer Mónica M. , Alcalá Luis , Peñalver Enrique 
Published: November 2020

AbstractFossil records of vertebrate integuments are relatively common in both rocks, as compressions, and amber, as inclusions. The integument remains, mainly the Mesozoic ones, are of great interest due to the panoply of palaeobiological information they can provide. We describe two Spanish Cretaceous amber pieces that are of taphonomic importance, one bearing avian dinosaur feather remains and the other, mammalian hair. The preserved feather remains originated from an avian dinosaur resting in contact with a stalactite-shaped resin emission for the time it took for the fresh resin to harden. The second piece shows three hair strands recorded on a surface of desiccation, with the characteristic scale pattern exceptionally well preserved and the strands aligned together, which can be considered the record of a tuft. These assemblages were recorded through a rare biostratinomic process we call “pull off vestiture” that is different from the typical resin entrapment and embedding of organisms and biological remains, and unique to resins. The peculiarity of this process is supported by actualistic observations using sticky traps in Madagascar. Lastly, we reinterpret some exceptional records from the literature in the light of that process, thus bringing new insight to the taphonomic and palaeoecological understanding of the circumstances of their origins.
Similarities and differences between the ‘cytokine storms’ in acute dengue and COVID-19
Authors: Dayarathna Shashika , Jeewandara Chandima , Gomes Laksiri , Somathilaka Gayasha , Jayathilaka Deshni , Vimalachandran Vimalahan , Wijewickrama Ananda , Narangoda Eranga , Idampitiya Damayanthi , Ogg Graham S. , Malavige Gathsaurie Neelika 
Published: November 2020

AbstractSevere pneumonia and multiorgan dysfunction in COVID-19 and dengue haemorrhagic fever (DHF) are two diseases that can associate with an altered immune response to the infecting virus. To determine the similarities and differences in the cytokine and chemokine responses in these two infections, we compared responses in patients with varying severity of COVID-19 and acute dengue at different time points of illness. During early disease, patients who proceeded to develop COVID-19 severe pneumonia (SP) and DHF had significantly higher levels of IL-6, IL-10 and MIP3α than those who developed mild illness. The lowest levels of IFNγ in early illness were seen in those who succumbed to their illness due to COVID-19. Levels of serum IL-10 (p = 0.0001), IL-6 (p = 0.002), MIP-3α (p = 0.02) and CD40-L levels (p = 0.002) significantly increased from 5 to 9 day of illness to 10–21 day of illness in patients with moderate-to-severe COVID-19, but not in those with mild illness. In contrast, these cytokine/chemokine levels remained unchanged in those with DHF or dengue fever (DF) during febrile and critical phases. Although IL-10 levels were significantly higher in COVID-19 patients with SP, patients with DHF had 25-fold higher levels, whereas IL-6 levels were 11-fold higher in those with COVID-19 SP. IL-10 and other cytokines were evaluated in a larger cohort of patients during early illness (≤ 4 days) who proceeded to develop DF (n = 71) or DHF (n = 64). Of the cytokines evaluated, IL-10 was significantly higher (p < 0.0001) in those who went on to develop DHF compared to DF. Low IFNγ response to the SARS-CoV2 and high levels of immunosuppressive IL-10 in both COVID-19 and dengue during early illness are indicators of an altered antiviral response potentially contributing to disease severity.
First freshwater mussel-associated piscicolid leech from East Asia
Authors: Bolotov Ivan N. , Klass Anna L. , Konopleva Ekaterina S. , Bespalaya Yulia V. , Gofarov Mikhail Yu. , Kondakov Alexander V. , Vikhrev Ilya V. 
Published: November 2020

AbstractParasites and symbionts of freshwater mussels are poorly understood, although a diverse assemblage of mussel-associated leeches (Glossiphoniidae) was recently described. Here, we report on the discovery of a fish leech (Piscicolidae) in the mantle cavity of the freshwater mussel Cristaria plicata (Unionidae) in the Russian Far East. It is the first member of this leech family being associated with freshwater molluscs. This leech does not match any known genus and species both morphologically and genetically, and is described here as Alexandrobdella makhrovigen. & sp. nov. It uses mussels as shelter (and probably as a secondary host), while the Amur catfish Silurus asotus (Siluridae) seems to be the primary host. These novel findings indicate that mussel-associated leech assemblage contains at least one piscicolid species. Our fossil-calibrated phylogeny suggests that the crown group of Piscicolidae was originated in the Early Cretaceous. This primarily marine family shares at least five independent colonization events into freshwater environments.
Path-based extensions of local link prediction methods for complex networks
Authors: Aziz Furqan , Gul Haji , Uddin Irfan , Gkoutos Georgios V. 
Published: November 2020

AbstractLink prediction in a complex network is a problem of fundamental interest in network science and has attracted increasing attention in recent years. It aims to predict missing (or future) links between two entities in a complex system that are not already connected. Among existing methods, local similarity indices are most popular that take into account the information of common neighbours to estimate the likelihood of existence of a connection between two nodes. In this paper, we propose global and quasi-local extensions of some commonly used local similarity indices. We have performed extensive numerical simulations on publicly available datasets from diverse domains demonstrating that the proposed extensions not only give superior performance, when compared to their respective local indices, but also outperform some of the current, state-of-the-art, local and global link-prediction methods.