bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychological distance in consumer psychology: Consequences and antecedents
Authors: Maglio Sam J. 
Published: November 2019

AbstractWherever consumers envision faraway locations, remember the past, predict the future, consider the perspective of others, or entertain remote possibilities, their minds extrapolate beyond what lies in front of them to something psychologically distant. Conjuring and considering that which is psychologically distant thus lies at the heart of how most people spend a substantial portion of their lives. As integrated here, seeing something as psychologically distant causes people to think about and act on it in systematically different ways than the same thing seen as psychologically close. Recent advances in these consequences suggest that the effects of psychological distance on consumer decision‐making continue to grow increasingly nuanced. Consumer outcomes thus at times benefit from seeing things as near and, at other times, benefit from seeing things as far. Accordingly, this review thereafter summarizes the antecedents that lead people to see things as psychologically distant or psychologically close. It closes in considering how future considerations might expand the conceptualization and application of psychological distance.
Self‐control: Information, priorities, and resources
Authors: Laran Juliano 
Published: November 2019

AbstractPeople routinely encounter situations in which they have to decide between following their long‐term interests and seeking short‐term pleasure. An act of self‐control occurs when people follow their long‐term interests (e.g., eat healthy food, save money), whereas an act of indulgence occurs when people seek short‐term pleasure (e.g., eat tasty but unhealthy food, spend a lot of money). Avoiding the temptation of short‐term pleasures is often difficult, and sometimes indulgence can lead to harmful outcomes. For this reason, research has understandably focused on uncovering the many factors that can facilitate or undermine self‐control. However, making sense of this voluminous output is difficult without an organizing framework. This article provides such a framework, which organizes previous findings around three psychological processes: information activation and inhibition, priority setting, and responses to resource availability. The article concludes with a discussion of research ideas in areas that will be especially relevant moving forward.
Summative and Formative Style Anatomy Practical Examinations: Do They Have Impact on Students’ Performance and Drive for Learning?
Authors: Mogali Sreenivasulu Reddy , Rotgans Jerome I. , Rosby Lucy , Ferenczi Michael Alan , Low Beer Naomi 
Published: November 2019

Anatomical knowledge is commonly assessed by practical examinations that are often administered in summative format. The format of anatomy practical examination was changed at the Lee Kong Chian School of Medicine in Singapore from summative (graded; must pass) to formative (ungraded; no pass/fail) in academic year (AY) 2017–2018. Both assessment formats were undertaken online, but the formative mode used a team‐based learning activity comprising individual and team assessments. This gave an unique opportunity to investigate: (1) the impact of two different online assessment formats on student performance in practical examination; (2) the impact of new formative practical examination on students’ performance in summative examinations; and (3) students’ opinions of these two practical examination formats. The class of 2021 perceptions was obtained as they experienced both formats. A retrospective cohort study was also conducted to analyze the Year 2 students’ performance in anatomy practical and year‐end summative examinations of cohorts AY 2015–2016, AY 2016–2017 (summative format), and AY 2017–2018 (formative format). There were no significant differences in students’ performance between two practical examination formats. The cohort who experienced the formative format, performed significantly better in summative examinations (mean ± SD: 82.32 ± 10.22%) compared with the cohort who experienced the summative format (73.77 ± 11.09%) (P < 0.001). Students highlighted positive features of the formative practical examination, including team reinforcement of learning, instant feedback, and enhanced learning. These findings indicate that students continue to study for anatomy practical examination without the need for external drivers. The team‐based learning style practical examination enhances students’ performance in summative examinations.
Second‐derivative synchronous spectrofluorimetric assay of dapagliflozin: Application to stability study and pharmaceutical preparation
Authors: Omar Mahmoud A. , Abdel Hamid Mohamed A. , Batakoushy Hany A. , Ahmed Hytham M. 
Published: November 2019

AbstractA highly accurate, simple and sensitive spectrofluorimetric analytical method for dapagliflozin (DGF) quantitation was developed. The proposed method was successively applied to DGF analysis in both its pure and pharmaceutical dosage forms. This method was developed to investigate DGF stability in its degradation products, as laid out in International Council for Harmonisation (ICH) rules. Kinetics of alkaline degradation of DGF was also calculated. The half‐life time (t1/2) of the reaction was 75.32 min. An alkaline degradation pathway was described. The present study involved measurement of the second‐derivative synchronous fluorescence intensity of DGF at Δλ = 30 nm. Peak amplitude was measured at 322 nm. Linear range of the calibration curve was 0.1–1.0 μg ml−1. Lower detection and quantitation limits were 0.023 and 0.071 μg ml−1, respectively, and indicated good sensitivity of the proposed method. Mean per cent recovery was 99.78 ± 1.78%. The proposed analytical approach was successfully applied to DGF in the quality control laboratory and would be suitable as a stability‐indicating assay.
Simultaneous quantification of five biogenic amines based on LC–MS/MS and its application in honeybee venom from different subspecies
Authors: Zhang Wenwen , Wang Xinran , Yang Shupeng , Niu Qingsheng , Wu Liming , Li Yi , Zhou Jinhui 
Published: November 2019

AbstractThe use of honeybee venom in traditional medicine is increasing due to its unexpected beneficial effects in the treatment of diseases. In this study, a simple and environmentally friendly sample preparation procedure was developed to quantify five biogenic amines—histamine, 5‐hydroxytryptamine, dopamine, adrenaline, and noradrenaline—in honeybee venom using high‐performance liquid chromatography tandem mass spectrometry. The instrument and sample preparation method were optimized to achieve stable, sensitive, and accurate quantification of the five biogenic amines. The peak purities of five biogenic amines in bee venom were examined using a diode array detector to ensure that endogenous impurities will not interfere with biogenic amines during the chromatographic separation procedure. The correlation coefficient of each compound was higher than 0.998 in the range of 0.5–1000 ng/mL. The limits of detection and quantification of the developed method ranged between 0.09 and 0.17, and 0.3 and 0.59 μg/g, respectively. The average recoveries of spiked biogenic amines with different concentrations were higher than 70.95%, and the intra‐ and intermediate‐day precisions were lower than 7.51% and 10.17%, respectively. The carry‐over between each injection and the stability of the target analytes were also evaluated to ensure the effectiveness of this method. The data obtained are presented in various formats, including boxplot, heat map, and principal component analysis diagram, to visualize the differences in the biogenic amine contents of the honeybee venoms from different subspecies. This method hopes to provide the opportunity to distinguish the bee venom produced by different subspecies.
Functional and structural changes in the visual pathway in multiple sclerosis
Authors: Carcelén‐Gadea María , Quintanilla‐Bordás Carlos , Gracia‐García Alicia , García‐Villanueva Carolina , Jannone‐Pedro Nicolás , Álvarez‐Sánchez Lourdes , Vilaplana‐Domínguez Laura , Blanco‐Hernández Trinidad , Pons‐Amate José Miguel , Cervelló‐Donderis Angeles 
Published: November 2019

AbstractIntroductionMultiple sclerosis (MS) is a heterogeneous disease with an unpredictable course. Visual pathway is a target of the disease and may reflect mechanisms that lead to disability. Structural and functional changes in the visual pathway may be studied by noninvasive techniques such as optical coherence tomography (OCT), visual evoked potentials (VEP), or B‐mode transorbital sonography (TOS).ObjectivesThe aim is to assess changes in the visual pathway in eyes of MS patients with and without a history of optic neuritis over a 3‐year period and to explore their relationship with disability.Materials and MethodsIn total, 112 eyes from 56 patients with relapsing MS were recruited: 29 with, and 83 without a history of ON (hON and nhON, respectively). Several parameters were measured by OCT, VEP, and TOS. Baseline measurements were also compared to 29 healthy controls. At 36 months, measurements were repeated in all eyes.ResultsAt baseline, all tests showed significant differences in optic nerve structure and function in both patient cohorts in all the parameters studied, suggestive of more impairment of the visual pathway among the hON cohort. OCT showed significant differences between healthy controls and the nhON cohort. At 36 months, the nhON cohort showed significant changes by OCT, VEP, and TOS suggestive of further visual pathway impairment. OCT measurements also correlated with baseline EDSS among the nhON cohort.ConclusionsOCT is the most suitable technique and outperforms VEP and TOS to detect subclinical damage in the visual pathway. It discriminated MS patients from healthy controls and showed a progressive decline in optic nerve thickness over time among these patients.
Advances in IKBKE as a potential target for cancer therapy
Authors: Yin Min , Wang Xin , Lu Jie 
Published: November 2019

AbstractIKBKE (inhibitor of nuclear factor kappa‐B kinase subunit epsilon), a member of the nonclassical IKK family, plays an important role in the regulation of inflammatory reactions, activation and proliferation of immune cells, and metabolic diseases. Recent studies have demonstrated that IKBKE plays a crucial regulatory role in malignant tumor development. In recent years, IKBKE, an important oncoprotein in several kinds of tumors, has been widely found to regulate a variety of cytokines and signaling pathways. IKBKE promotes the growth, proliferation, invasion, and drug resistance of various cancers. This paper makes a detailed review that focuses on the recent discoveries of IKBKE in the malignant tumors, and puts forward that IKBKE is becoming an important therapeutic target for clinical treatment, which has been more and more realized.
Extranodal marginal zone B‐cell lymphoma of mucosa‐associated lymphoid tissue in the oromaxillofacial head and neck region: A retrospective analysis of 105 patients
Authors: Zhang Tian , Wu Yunteng , Ju Houyu , Meng Jian , Guo Wei , Ren Guoxin 
Published: November 2019

AbstractBackgroundExtranodal marginal zone B‐cell lymphoma of mucosa‐associated lymphoid tissue (MALT lymphoma) in the oromaxillofacial head and neck region is rare, with limited data available. This retrospective study explored the clinical features, stage, treatment, and prognosis of this disease.MethodsOverall, 105 patients with MALT lymphomas in the oromaxillofacial head and neck region were included in this retrospective analysis. SPSS 22.0 software package was used for data analysis and a two‐tailed P value of ≤.05 was considered statistically significant. Primary endpoints of the study were the complete response (CR) rate, overall survival (OS), and progression‐free survival (PFS).ResultsAbout 52% of the patients had long‐term xerostomia, autoimmune diseases, or chronic parotitis and 81% had diseases involving the large salivary glands. Ann Arbor staging of the patients was as follows: stages I/II, 73 patients and stages III/IV, 32 patients. In the 97 patients followed up, CR rate after initial treatment was 80%. Tumor progression was observed in 12 patients and 14 patients died. There was a significant difference between the rate of CR in localized (87%) and disseminated (67%) lymphoma patients (P = .02). The 5‐ and 10‐year PFS of the localized lymphoma patients were both 91%, whereas those of the disseminated lymphoma patients were 83% and 65%, respectively (P = .03). The 5‐year PFS rates of the chemotherapy and non‐chemotherapy groups in the disseminated lymphoma patients were 85% and 73% (P = .04). Meanwhile, the 5‐year PFS rates of the rituximab and non‐rituximab groups in the disseminated lymphoma patients were 100% and 70% (P = .03). In multivariate analysis, MALT Lymphoma International Prognostic Index (MALT‐IPI) was an independent prognostic factor affecting OS, whereas Ann Arbor staging affected PFS.ConclusionsThis study suggests that the outcome after initial treatment of MALT lymphomas in the oromaxillofacial head and neck region is satisfactory and that this disease progresses slowly. The CR rate and PFS of localized lymphoma patients are better than those of disseminated lymphoma patients. Systemic treatment (chemotherapy or rituximab) may improve PFS in disseminated disease patients. MALT‐IPI and Ann Arbor staging are independent prognostic factors.
The effect of disgust on preference for structure: Evidence for a double‐sided response
Authors: Donato Carmela , Miceli Gaetano 
Published: November 2019

AbstractThe literature on emotions converges on the idea that people cope with the undesired effects of disgust through an immediate response of avoidance aimed to the physical and psychological rejection of any contamination threat. However, previous research does not consider what happens after this immediate response. We investigate the dual response to disgust and propose that disgust generates an immediate preference for structure, but also an opposite, subsequent tendency to prefer unstructured stimuli. Our reasoning is based on the mobilization‐minimization theory, which suggests opposed reactions to negative emotions. We demonstrate that, while immediate reactions to disgust imply preference for structured logos, after the disgust‐eliciting stimulus is eliminated from the environment, people show higher preference for visually unstructured logos. The study of the dual response to disgust offers novel insights to consumer behavior, decision‐making, and emotion literature, showing that a typically avoidance‐triggering emotion, that is, disgust, can then lead to opposite effects in terms of preference for structure.
Cancer‐associated fibroblasts promote malignancy of gastric cancer cells via Nodal signalling
Authors: Pang Tao , Yin Xiaoyi , Luo Tianhang , Lu Zhengmao , Nie Mingming , Yin Kai , Xue Xuchao 
Published: November 2019

The roles of cancer‐associated fibroblasts (CAFs) in progression of gastric cancer (GC) are far from well illustration. Here, we show that CAFs can trigger the proliferation and decrease the doxorubicin (Dox) sensitivity of GC cells via secretion of Nodal, one embryonic morphogen that can promote malignancy of various cancers. The neutralization antibody of Nodal can attenuate CAFs‐induced cell proliferation. Further, CAFs can activate the Smad2/3 signal, which further increase the phosphorylation and nuclear localization of Akt, in GC cells. While anti‐Nodal can abolish the CAFs‐induced activation of Smad2/3/Akt signals. Further, both inhibitors of Smad2/3 and Akt can attenuate CAFs‐induced proliferation of GC cells. All these data suggest that CAFs can increase the malignancy of GC cells via Nodal‐induced activation of Smad2/3/Akt signals. It indicates that CAFs/Nodal signals might be a potential new target of clinical interventions for GC patients.Significance of the studyThe roles about CAFs in progression of GC are not well illustrated. Our present study reveals that CAFs can increase the proliferation and decrease the Dox sensitivity of GC cells via secretion of Nodal. The secreted Nodal further activated Samd2/3/Akt signals to trigger the GC progression. It suggests that targeted inhibition CAFs/Nodal might be a potential approach for GC therapy.
Effect of L‐cysteine on the rheology and baking quality of doughs formulated with flour from five contrasting Canada spring wheat cultivars
Authors: Tozatti Patricia , Fleitas María Constanza , Briggs Connie , Hucl Pierre , Chibbar Ravindra N. , Nickerson Michael T. 
Published: November 2019

AbstractBackground and ObjectivesWheat grain quality parameters are influenced by the composition of gluten proteins. To overcome wheat grain quality limitations, dough improvers such as reducing agents can be added to reduce mixing time and improve dough extensibility. The overall objective of this research was to examine the effect of L‐cysteine (L‐cys) concentration on the rheology and baking quality of doughs prepared using five western Canadian spring wheat cultivars.FindingsThe addition of L‐cys resulted in a significant (p < .05) decrease in dough strength and handling properties, where stronger gluten strength wheats were less affected by addition and had improved dough handling properties, loaf volume, and softer crumb structure.ConclusionsThe addition of L‐cys to wheat flours reduced mixing time up to 47%, increased loaf volume (up to 9%), and elasticity of the products, those characteristics are desired to increase the efficiency of the automated processes for bread products.Significance and noveltyThe optimization of time versus quality of bread is crucial for the industry. Therefore, reducing agents can be used in stronger wheat cultivars as means to improve efficiency of production (i.e., lower mixing time) and result in equal or higher quality bread loaf (i.e., loaf volume).
Impacts of size fractionation, commingling, and drying temperature on physical and pasting properties of broken rice kernels
Authors: Bruce Rebecca M. , Atungulu Griffiths G. , Sadaka Sammy 
Published: November 2019

AbstractBackground and objectivesInconsistencies in rice flour produced from broken rice (brokens) may be due to differences in size, composition, and processing methods of the brokens. This study sought to investigate the effect of size fractionation, drying temperature, and commingling practices on the physical and pasting properties of broken rice. Broken rice was generated from rice (cultivar XP753) dried at 25, 45, and 60°C. The brokens were classified into large, medium, and small sizes using US sieve size 10 (2.00 mm), 12 (1.68 mm), and 20 (0.84 mm), respectively. Commingling of the brokens based on size was done. Physical and pasting properties of broken rice flour were analyzed.FindingsDrying temperature and size of brokens had significant impacts on protein content, starch damage content, bulk density, peak viscosity, trough viscosity, breakdown viscosity, final viscosity, and peak time of brokens. Comingled samples were not significantly different from at least one of the individual constituents of the comingled flour for most of the properties measured. Developed models predicted large brokens obtained from drying at 60°C as the most suitable for products requiring high peak and final viscosities and short peak time. Small brokens obtained from drying at 60°C were predicted as the most suitable for high protein and low starch damage products. The impact of size, drying temperature, and commingling on the physical and pasting properties of brokens may be due to variations in rice composition across the length of the rice kernel, variations in kernel thickness, differences in degrees of milling of different parts of the rice kernel, modifications in the starch structure during drying, and differences in protein content and functionality of the brokens.ConclusionsDrying temperature and size fractionation of brokens are important in maintaining consistency in the cooking properties of broken rice and resulting products.Significance and noveltySize fractionation of brokens and control of drying temperature provides the opportunity to better understand the functionality of brokens, control commingling practices, direct brokens to the right end‐use processes, and maximize the potential of this by‐product in producing premium products.
Electrochemically Controlled Reversible Lithium Capture and Release Enabled by LiMn2O4 Nanorods
Authors: Xie Ning , Li Yaqian , Lu Yue , Gong Jingming , Hu Xianluo 
Published: November 2019

AbstractNowadays the world's demand for lithium extraction has been vigorously growing, especially driven by an increased lithium use in new consumer electronic battery technologies and electric cars. Conventional methods for industrial lithium production from two major sources of underground brine deposits and mineral ore deposits are straightforward, but time‐consuming from several months to a few years to complete. Therefore, efficient and low‐energy‐consuming lithium extraction is highly desirable. Here, we develop an attractive electrochemical method for lithium recovery with low energy consumption and high selectivity based on a cell system using LiMn2O4 nanorods. Despite the presence of other cations, lithium ions can be selectively recovered from brine with a low energy consumption of 1.76 Wh mol−1. The resulting electrochemical cell system using LiMn2O4 nanorods exhibits outstanding cyclability with a recovery capacity retention of 37.4 % over 200 cycles. The lithium extraction strategy is effective and economical, which holds great promise for future lithium recycling.
Mathematical and numerical challenges in optical screening of female breast
Authors: Causin Paola , Lupieri Marina G. , Naldi Giovanni , Weishaeupl Rada‐M. 
Published: November 2019

AbstractDiffuse optical tomography (DOT) is an emerging imaging technique which uses light for diagnostic purposes in a non‐invasive and non‐ionizing way. In this paper, we focus on DOT application to female breast screening, where the surface of the breast is illuminated by light sources and the outgoing light is collected on the surface. The comparison of measured light data with the equivalent field obtained from a relevant mathematical model yields the DOT inverse problem whose solution provides an estimate of the optical coefficients of the tissue. These latter, in turn, can be related to clinical markers for cancer detection. The goal of this work is to propose a mathematical and computational approach tailored to the concept of a DOT imaging device able to perform fast and accurate screenings at an affordable cost. Namely, we address two original points about the crucial issue of the solution of the severely ill‐conditioned DOT inverse problem: (a) a computational approach based on Green's functions which do not require the exact knowledge of the tissue geometry, proposed here in the declination of the Method of Fundamental Solutions, which allows to enforce correct boundary conditions; (b) the elastic net regularization technique that shares the desirable properties of both theℓ2‐ andℓ1‐norm penalization approaches and opens the possibility for sparsity recognition in the optical coefficients field and refinement procedures.