bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Activating Deletion Variant in the Submembrane Region of Natriuretic Peptide Receptor-B Causes Tall Stature
Authors: Lauffer Peter , Miranda-Laferte Erick , van Duyvenvoorde Hermine A , van Haeringen Arie , Werner Franziska , Boudin Eveline , Schmidt Hannes , Mueller Thomas D , Kuhn Michaela , van der Kaay Daniëlle C M 
Published: April 2020

Abstract

Context
C-type natriuretic peptide (CNP) is critically involved in endochondral bone growth. Variants in the genes encoding CNP or its cyclic guanosine monophosphate (cGMP)-forming receptor (natriuretic peptide receptor-B [NPR-B], gene NPR2) cause monogenic growth disorders. Here we describe a novel gain-of-function variant of NPR-B associated with tall stature and macrodactyly of the great toes (epiphyseal chondrodysplasia, Miura type).

Design
History and clinical characteristics of 3 family members were collected. NPR2 was selected for sequencing. Skin fibroblasts and transfected HEK-293 cells were used to compare mutant versus wild-type NPR-B activities. Homology modeling was applied to understand the molecular consequences of the variant.

Results
Mother’s height was +2.77 standard deviation scores (SDS). The heights of her 2 daughters were +1.96 SDS at 7 years and +1.30 SDS at 4 years of age. Skeletal surveys showed macrodactyly of the great toes and pseudo-epiphyses of the mid- and proximal phalanges. Sequencing identified a novel heterozygous variant c.1444_1449delATGCTG in exon 8 of NPR2, predicted to result in deletion of 2 amino acids Met482-Leu483 within the submembrane region of NPR-B. In proband’s skin fibroblasts, basal cGMP levels and CNP-stimulated cGMP production were markedly increased compared with controls. Consistently, assays with transfected HEK-293 cells showed markedly augmented baseline and ligand-dependent activity of mutant NPR-B.

Conclusions
We report the second activating variant within the intracellular submembrane region of NPR-B resulting in tall stature and macrodactyly. Our functional and modeling studies suggest that this domain plays a critical role in the baseline conformation and ligand-dependent structural rearrangement of NPR-B required for cGMP production.
Effect of Dural Puncture Epidural Technique Combined With Programmed Intermittent Epidural Bolus on Labor Analgesia Onset and Maintenance: A Randomized Controlled Trial
Authors: Song Yujie , Du Weijia , Zhou Shuangqiong , Zhou Yao , Yu Yibing , Xu Zhendong , Liu Zhiqiang 
Published: April 2020

BACKGROUND:
The dural puncture epidural (DPE) technique is associated with faster onset than the conventional epidural (EP) technique for labor analgesia. The programmed intermittent epidural bolus (PIEB) mode for maintaining labor analgesia allows for lower anesthetic drug consumption than the continuous epidural infusion (CEI) mode. Whether DPE technique with PIEB mode offers additional benefits for analgesia onset, local anesthetic drug consumption, and side effects versus EP or DPE techniques with CEI mode remains unclear.

METHODS:
Nulliparous women with a visual analog scale (VAS) pain score >50 mm and cervical dilation <5 cm were randomly assigned to receive EP + CEI, DPE + CEI, or DPE + PIEB for labor analgesia. A 25-gauge needle was used for dural puncture. Analgesia was initiated with 10 mL of 0.1% ropivacaine with 0.3 µg/mL of sufentanil and maintained with the same solution at 8 mL/h in all groups. A 5-mL patient-controlled epidural analgesia (PCEA) bolus was programmed with a 20-minute lockout. Breakthrough pain not amendable by PCEA was treated with provider boluses of 5 mL of 0.125% ropivacaine. The primary outcome was “time to adequate analgesia,” defined as a VAS pain score ≤30 mm during 2 consecutive contractions, and was analyzed using Kaplan–Meier curves and a Cox proportional hazard model. Secondary outcomes included the VAS scores, ropivacaine consumption, sensory block level to ice, PCEA and provider boluses intervention, mode of delivery, duration of labor, Bromage scores, Apgar scores, occurrence of side effects, and maternal satisfaction with the anesthesia.

RESULTS:
A total of 116 women were included (38 in the EP + CEI group, 40 in the DPE + CEI group, and 38 in the DPE + PIEB group). Adequate anesthesia was achieved faster in the DPE + CEI and DPE + PIEB groups than in the EP + CEI group (hazard ratio = 1.705; 95% confidence interval [CI], 1.039–2.800; P = .015; and hazard ratio = 1.774; 95% CI, 1.070–2.941; P = .012, respectively). DPE technique with PIEB mode was associated with the fewest PCEA boluses and the lowest hourly ropivacaine consumption (both P < .001). There were no differences in the duration of labor, mode of delivery, Bromage scores, newborn Apgar scores, incidence of side effects, and maternal satisfaction scores among the groups.

CONCLUSIONS:
The use of DPE technique for neuraxial analgesia was associated with faster onset than the use of the EP technique. DPE technique with PIEB mode achieved the greatest drug-sparing effect without increasing maternal or neonatal side effects.
In Pursuit of an Opioid-Free Pediatric Ambulatory Surgery Center: A Quality Improvement Initiative
Authors: Franz Amber M. , Martin Lynn D. , Liston David E. , Latham Gregory J. , Richards Michael J. , Low Daniel K. 
Published: April 2020

BACKGROUND:
Opioids have been a central component of routine adult and pediatric anesthesia for decades. However, the long-term effects of perioperative opioids are concerning. Recent studies show a 4.8%–6.5% incidence of persistent opioid use after surgery in older children and adults. This means that >2 million of the 50 million patients undergoing elective surgeries in the United States each year are likely to develop persistent opioid use. With this in mind, anesthesiologists at Bellevue Clinic and Surgery Center assembled an interdisciplinary quality improvement team focused on 2 goals: (1) develop effective anesthesia protocols that minimize perioperative opioids and (2) add value to clinical services by maintaining or improving perioperative outcomes while reducing costs. This article describes our project and findings but does not attempt to make inferences or generalizations about populations outside our facility.

METHODS:
We performed a large-scale implementation of opioid-sparing protocols at our standalone pediatric clinic and ambulatory surgery facility, based in part on the prior success of our previously published tonsillectomy and adenoidectomy protocol. Multiple Plan-Do-Study-Act cycles were performed using data captured from the electronic medical record. The percentage of surgical patients receiving intraoperative opioids and postoperative morphine preintervention and postintervention were compared. The following measures were evaluated using statistical process control charts: maximum postoperative pain score, postoperative morphine rescue rate, total postanesthesia care unit minutes, total anesthesia minutes, and postoperative nausea and vomiting rescue rate. Intraoperative analgesic costs were calculated.

RESULTS:
Between January 2017 and June 2019, 10,948 surgeries were performed at Bellevue, with 10,733 cases included in the analyses. Between December 2017 and June 2019, intraoperative opioid administration at our institution decreased from 84% to 8%, and postoperative morphine administration declined from 11% to 6% using analgesics such as dexmedetomidine, nonsteroidal anti-inflammatory drugs, and regional anesthesia. Postoperative nausea and vomiting rescue rate decreased, while maximum postoperative pain scores, total anesthesia minutes, and total postanesthesia care unit minutes remained stable per control chart analyses. Costs improved.

CONCLUSIONS:
By utilizing dexmedetomidine, nonsteroidal anti-inflammatory drugs, and regional anesthesia for pediatric ambulatory surgeries at our facility, perioperative opioids were minimized without compromising patient outcomes or value.
Laser mode locking using a single-mode-fiber coil with enhanced polarization-dependent loss
Authors: Jiang Hongbo , Huang Yunpeng , Zhao Zihao , Shirahata Takuma , Jin Lei , Yamashita Shinji , Set Sze Y. 
Published: April 2020

A laser mode-locking phenomenon based on polarization-dependent loss (PDL) using a passive fiber coil is demonstrated. We propose using a fiber coil operating in low-V-number regime to achieve an enhanced bend-induced PDL and to maintain a reasonable bend loss. A mode-locked thulium doped all-fiber laser is shown using the low-V-number fiber coil. The results indicate that a moderate amount of PDL at 1 dB is sufficient to initiate and sustain a stable CW mode-locking operation. To the best of our knowledge, this is the first demonstration of a CW mode-locked fiber laser based on PDL enabled by a fiber coil.
White-light flashlight activated up-conversion luminescence for ultraviolet-B tagging
Authors: Wang Aiying , Liu Yichun , Wang Xiao-Jun , Liu Feng 
Published: April 2020

Optical tagging technology with emission in the ultraviolet region upon visible-light excitation is promising for objects identified in visually bright environments, while the relevant research is absent. Here we put forward a covert tagging concept, which is based on up-converting phosphors (e.g.,

L
u

3

A
l

5

O

12

:

P
r

3
+

) with emission peaking in the ultraviolet-B region (UV-B, 290−320 nm). A white-light flashlight serves as excitation source to make the up-converter emit, and an ultraviolet camera is applied to see such an emission wavelength range. This Letter expands the excitation source for an up-conversion process to a convenient flashlight for the first time, to the best of our knowledge. Moreover, such a flashlight-pumped UV-B tagging technology is generally applicable for many other phosphors, which can be utilized to mark and differentiate objects in commercial, civilian, or military applications.
Esophageal Bronchial Artery Fistulaization: A Complication of an Endobronchial Ultrasound
Authors: Jadeja Sonal , Green Kevin , Shuja Asim , Malespin Miguel , De Melo Silvio 
Published: April 2020

ABSTRACT
Bronchial artery pseudoaneurysms are an extremely rare cause of upper gastrointestinal bleeding. The presence of a bronchial artery pseudoaneurysm resulting in an esophageal fistula is an entity that, to our knowledge, has yet to be described. Successful management requires an interdisciplinary approach to guide closure of the defects. We present a novel case of an esophageal fistula and bronchial artery pseudoaneurysm resulting from an endobronchial ultrasound-guided transbronchial needle aspiration successfully managed by endoscopic therapy and coil embolization.
Automatic Recognition of Arabic Poetry Meter from Speech Signal using Long Short-term Memory and Support Vector Machine
Authors: Al-Talabani Abdulbasit K. 
Published: April 2020

The recognition of the poetry meter in spoken lines is a natural language processing application that aims to identify a stressed and unstressed syllabic pattern in a line of a poem. Stateof-the-art studies include few works on the automatic recognition of Arud meters, all of which are text-based models, and none is voice based. Poetry meter recognition is not easy for an ordinary reader, it is very difficult for the listener and it is usually performed manually by experts. This paper proposes a model to detect the poetry meter from a single spoken line (“Bayt”) of an Arabic poem. Data of 230 samples collected from 10 poems of Arabic poetry, including three meters read by two speakers, are used in this work. The work adopts the extraction of linear prediction cepstrum coefficient and Mel frequency cepstral coefficient (MFCC) features, as a time series input to the proposed long short-term memory (LSTM) classifier, in addition to a global feature set that is computed using some statistics of the features across all of the frames to feed the support vector machine (SVM) classifier. The results show that the SVM model achieves the highest accuracy in the speakerdependent approach. It improves results by 3%, as compared to the state-of-the-art studies, whereas for the speaker-independent approach, the MFCC feature using LSTM exceeds the other proposed models.
How middle school special and general educators make sense of and respond to changes in teacher evaluation policy
Authors: Braun Alisha M. B. , Youngs Peter 
Published: April 2020

In this multiple case study, we apply sensemaking theory to examine and compare how middle school special and general educators perceive and respond to teacher evaluation reform, including formal classroom observations, informal walkthroughs, and student growth measures. Our findings reveal that special educators experience conflict between the policy’s main elements and their understandings of how to effectively teach students with disabilities. Furthermore, special and general educators held contrasting beliefs regarding the appropriateness of evaluation. Our findings illustrate the importance of acknowledging differences in special and general educators’ roles and responsibilities and encourage policymakers to reconsider uniform teacher evaluation policies.
Neurofeedback-Linked Suppression of Cortical β Bursts Speeds Up Movement Initiation in Healthy Motor Control: A Double-Blind Sham-Controlled Study
Authors: He Shenghong , Everest-Phillips Claudia , Clouter Andrew , Brown Peter , Tan Huiling 
Published: April 2020

Abnormally increased β bursts in cortical-basal ganglia-thalamic circuits are associated with rigidity and bradykinesia in patients with Parkinson's disease. Increased β bursts detected in the motor cortex have also been associated with longer reaction times (RTs) in healthy participants. Here we further hypothesize that suppressing β bursts through neurofeedback training can improve motor performance in healthy subjects. We conducted a double-blind sham-controlled study on 20 human volunteers (10 females) using a sequential neurofeedback-behavior task with the neurofeedback reflecting the occurrence of β bursts over sensorimotor cortex quantified in real time. The results show that neurofeedback training helps healthy participants learn to volitionally suppress β bursts in the sensorimotor cortex, with training being accompanied by reduced RT in subsequent cued movements. These changes were only significant in the real feedback group but not in the sham group, confirming the effect of neurofeedback training over simple motor imagery. In addition, RTs correlated with the rate and accumulated duration of β bursts in the contralateral motor cortex before the go-cue, but not with averaged β power. The reduced RTs induced by neurofeedback training positively correlated with reduced β bursts across all tested hemispheres. These results strengthen the link between the occurrence of β bursts in the sensorimotor cortex before the go-cue and slowed movement initiation in healthy motor control. The results also highlight the potential benefit of neurofeedback training in facilitating voluntary suppression of β bursts to speed up movement initiation.SIGNIFICANCE STATEMENTThis double-blind sham-controlled study suggested that neurofeedback training can facilitate volitional suppression of β bursts in sensorimotor cortex in healthy motor control better than sham feedback. The training was accompanied by reduced reaction time (RT) in subsequent cued movements, and the reduced RT positively correlated with the level of reduction in cortical β bursts before the go-cue, but not with average β power. These results provide further evidence of a causal link between sensorimotor β bursts and movement initiation and suggest that neurofeedback training could potentially be used to train participants to speed up movement initiation.
Amygdalohippocampal Area Neurons That Project to the Preoptic Area Mediate Infant-Directed Attack in Male Mice
Authors: Sato Keiichiro , Hamasaki Yumi , Fukui Kiyoshiro , Ito Kazuki , Miyamichi Kazunari , Minami Masabumi , Amano Taiju 
Published: April 2020

Male animals may show alternative behaviors toward infants: attack or parenting. These behaviors are triggered by pup stimuli under the influence of the internal state, including the hormonal environment and/or social experiences. Converging data suggest that the medial preoptic area (MPOA) contributes to the behavioral selection toward the pup. However, the neural mechanisms underlying how integrated stimuli affect the MPOA-dependent behavioral selection remain unclear. Here we focus on the amygdalohippocampal area (AHi) that projects to MPOA and expresses oxytocin receptor, a hormone receptor mediating social behavior toward pups. We describe the activation of MPOA-projection AHi neurons in male mice by social contact with pups. Input mapping using the TRIO method reveals that MPOA-projection AHi neurons receive prominent inputs from several regions, including the thalamus, hypothalamus, and olfactory cortex. Electrophysiological and histologic analysis demonstrates that oxytocin modulates inhibitory synaptic responses on MPOA-projection AHi neurons. In addition, AHi forms the excitatory monosynapse to MPOA, and pharmacological activation of MPOA-projection AHi neurons enhances only aggressive behavior, but not parental behavior. Interestingly, this promoted behavior was related to social experience in male mice. Collectively, our results identified a presynaptic partner of MPOA that can integrate sensory input and hormonal state, and trigger pup-directed aggression.SIGNIFICANCE STATEMENTThe medial preoptic area (MPOA) plays critical roles in parental behavior, such as motor control, motivation, and social interaction. The MPOA projects to multiple brain regions, and these projections contribute to several neural controls in parental behavior. In contrast, how inputs to MPOA are regulated by social and environmental information is poorly understood. In this study, we focus on the amygdalohippocampal area (AHi) that connects to MPOA and expresses oxytocin receptor. We demonstrate the disruption of the expression of parental behavior triggered by the activation of MPOA-projection AHi neurons. This behavior may be regulated not only by oxytocin but also by neural input from several regions.
Sensorimotor Expectations Bias Motor Resonance during Observation of Object Lifting: The Causal Role of pSTS
Authors: Rens Guy , van Polanen Vonne , Botta Alessandro , Gann Mareike A. , Orban de Xivry Jean-Jacques , Davare Marco 
Published: April 2020

Transcranial magnetic stimulation studies have highlighted that corticospinal excitability is increased during observation of object lifting, an effect termed “motor resonance.” This facilitation is driven by movement features indicative of object weight, such as object size or observed movement kinematics. Here, we investigated in 35 humans (23 females) how motor resonance is altered when the observer's weight expectations, based on visual information, do not match the actual object weight as revealed by the observed movement kinematics. Our results highlight that motor resonance is not robustly driven by object weight but easily masked by a suppressive mechanism reflecting the correctness of weight expectations. Subsequently, we investigated in 24 humans (14 females) whether this suppressive mechanism was driven by higher-order cortical areas. For this, we induced “virtual lesions” to either the posterior superior temporal sulcus (pSTS) or dorsolateral prefrontal cortex (DLPFC) before having participants perform the task. Importantly, virtual lesion of pSTS eradicated this suppressive mechanism and restored object weight-driven motor resonance. In addition, DLPFC virtual lesion eradicated any modulation of motor resonance. This indicates that motor resonance is heavily mediated by top-down inputs from both pSTS and DLPFC. Together, these findings shed new light on the theorized cortical network driving motor resonance. That is, our findings highlight that motor resonance is not only driven by the putative human mirror neuron network consisting of the primary motor and premotor cortices as well as the anterior intraparietal sulcus, but also by top-down input from pSTS and DLPFC.SIGNIFICANCE STATEMENTObservation of object lifting activates the observer's motor system in a weight-specific fashion: Corticospinal excitability is larger when observing lifts of heavy objects compared with light ones. Interestingly, here we demonstrate that this weight-driven modulation of corticospinal excitability is easily suppressed by the observer's expectations about object weight and that this suppression is mediated by the posterior superior temporal sulcus. Thus, our findings show that modulation of corticospinal excitability during observed object lifting is not robust but easily altered by top-down cognitive processes. Finally, our results also indicate how cortical inputs, originating remotely from motor pathways and processing action observation, overlap with bottom-up motor resonance effects.
Some Types of Archaisms in Polish Dialects in Lithuania
Authors: Ušinskienė Viktorija 
Published: April 2020

The subject of the article is related to the author’s work on the international project “Polish Dialects in Lithuania” (“Gwary polskie na Litwie”, 2016–2018). The purpose of this paper was to identify and study lexical archaisms in the dialect material selected by the project group. In the article the concept of ‘archaism’ is interpreted widely: both archaic and obsolete words are considered. In total, it was identified about 200 lexical units classified as obsolete or archaic: proper lexical archaisms constitute approximately 50% of the material (arenda, bachur, czernica etc.), semantic archaisms constitute about 35% (baczyć, cacka, czeladź etc.), and about 15% of the material are lexical word-building archaisms (kradkiem, lenować się, nadgrobek etc.). By comparing the studied material with the data of the historical sources, it was possible to realize that a number of lexemes qualified in some scientific papers as regionalisms borrowed from the Eastern Slavic languages should be recognized as archaisms, once known to the common Polish language. Тhe results allow us to confirm the undoubtedly significant role of the Belarusian and Russian languages in supporting the functioning of lexical archaisms in Polish dialects in Lithuania. About half of the identified lexical archaisms are also known to a number of dialects in Poland.
Зелінська Марія Зенонівна. Комунікативна компетенція молодих носіїв польської мови західних областей України
Authors: Geben Kinga 
Published: April 2020

Зелінська Марія Зенонівна. Комунікативна компетенція молодих носіїв польської мови західних областей України. Дрогобич: ПП «ПО́СВІТ», 2018. [Maria Zielińska. Kompetencja komunikacyjna młodych użytkowników języka polskiego zachodnich obwodów Ukrainy. Drohobycz: Wydawnictwo „Posvit”, 2018]. Monografia. Red. naukowy prof. Ałła M. Krawczuk, ss. 288. ISBN 978-617-7624-67-6.