bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rhetorical Appeals and Strategic Cooptation in the Rise and Fall of The New International Economic Order
Authors: Fioretos Orfeo 
Published: November 2020

AbstractThe global governance institutions that structure economic relations between industrialized and developing countries have been contested since their inception. This contribution revisits elements of the struggle over the ‘new international economic order’, or NIEO, in the 1970s. Contemporaneous observers and political leaders saw the initiative as part of the first major shift in global power after 1945. Using strategies of rhetorical coercion and persuasion that aimed to radically reform global economic governance, a large coalition of developing nations proposed a reform agenda designed to expand the authority of the United Nations and reduce the importance of Bretton Woods institutions. In response, a small coalition of industrialized countries adopted strategies of cooptation that entailed ‘case‐by‐case’ cooperation with developing countries with the goal of limiting overall reforms. The contribution uses historical archives from deliberations within and among industrialized countries to reveal the sources behind their response to the NIEO and follow‐up initiatives. It shows that industrialized countries chose to deemphasize strategies of argumentation in favor of strategies of cooptation in their efforts to limit transformative change in global economic governance.
Factors associated with gross motor development from birth to independent walking: A systematic review of longitudinal research
Authors: Boonzaaijer Marike , Suir Imke , Mollema Jurgen , Nuysink Jacqueline , Volman Michiel , Jongmans Marian 
Published: November 2020

AbstractAimThe aim of this study is to gain more insight into child and environmental factors that influence gross motor development (GMD) of healthy infants from birth until reaching the milestone of independent walking, based on longitudinal research.BackgroundA systematic search was conducted using Scopus, PsycINFO, MEDLINE and CINAHL to identify studies from inception to February 2020. Studies that investigated the association between child or environmental factors and infant GMD using longitudinal measurements of infant GMD were eligible. Two independent reviewers extracted key information and assessed risk of bias of the selected studies, using the Quality in Prognostic Studies tool (QUIPS). Strength of evidence (strong, moderate, limited, conflicting and no evidence) for the factors identified was described according to a previously established classification.ResultsIn 36 studies, six children and 11 environmental factors were identified. Five studies were categorized as having low risk of bias. Strong evidence was found for the association between birthweight and GMD in healthy full‐term and preterm infants. Moderate evidence was found for associations between gestational age and GMD, and sleeping position and GMD. There was conflicting evidence for associations between twinning and GMD, and breastfeeding and GMD. No evidence was found for an association between maternal postpartum depression and GMD. Evidence for the association of other factors with GMD was classified as ‘limited’ because each of these factors was examined in only one longitudinal study.ConclusionInfant GMD appears associated with two child factors (birthweight and gestational age) and one environmental factor (sleeping position). For the other factors identified in this review, insufficient evidence for an association with GMD was found. For those factors that were examined in only one longitudinal study, and are therefore classified as having limited evidence, more research would be needed to reach a conclusion.
CRISPR/Cas9‐induced nos2b mutant zebrafish display behavioral abnormalities
Authors: Gao Lei , Penglee Rachit , Huang Yajuan , Yi Xinxin , Wang Xiaojie , Liu Liping , Gong Xiaoling , Bao Baolong 
Published: November 2020

AbstractThe immunomodulatory function of nitric oxide synthase (NOS2) has been extensively studied. However, some behavioral abnormalities caused by its mutations have been found in a few rodent studies, of which the molecular mechanism remains elusive. In this research, we generated nos2b gene knockout zebrafish (nos2bsou2/sou2) using CRISPR/Cas9 approach and investigated their behavioral and molecular changes by doing a series of behavioral detections, morphological measurements, and molecular analyses. We found that, compared with nos2b+/+ zebrafish, nos2bsou2/sou2 zebrafish exhibited enhanced motor activity; additionally, nos2bsou2/sou2 zebrafish were characterized by smaller brain size, abnormal structure of optic tectum, reduced mRNA level of presynaptic synaptophysin and postsynaptic homer1, and altered response to sodium nitroprusside/methylphenidate hydrochloride treatment. These findings will likely contribute to future studies of behavioral regulation.
Krüppel‐like factor 6 promotes odontoblastic differentiation through regulating the expression of dentine sialophosphoprotein and dentine matrix protein 1 genes
Authors: Chen Z. , Xie H. , Yuan J. , Lan Y. , Xie Z. 
Published: November 2020

AbstractAimTo investigate the potential role of Krüppel‐like factor 6 (KLF6) in the odontoblastic differentiation of immortalized dental papilla mesenchymal cells (iMDP‐3) cells.MethodologyAlizarin Red S (ARS) and Alkaline phosphatase (ALP) staining was used to examine the mineralization effect of iMDP‐3 cells after odontoblastic induction. Real‐time PCR and Western blotting were employed to analyse dentine sialophosphoprotein (DSPP), dentine matrix protein 1 (DMP1), RUNX family transcription factor 2 (RUNX2), ALP and KLF6 expression during this process. Co‐expression of the KLF6 with DMP1, DSPP and RUNX2 was detected by double immunofluorescence staining to explore their local relationship in the cell. To further investigate KLF6 functions, Klf6 gain‐ and loss‐of‐function assays followed by ARS and ALP stainings, real‐time PCR and Western blotting were performed using Klf6‐overexpression plasmids and Klf6 siRNA to investigate whether changes in Klf6 expression affect the odontoblastic differentiation of iMDP‐3 cells. Dual‐luciferase reporter assays were used to elucidate the mechanistic regulation of Dspp and Dmp1 expression by Klf6. Means were compared using the unpaired t‐test and Kruskal–Wallis one‐way anova with P < 0.05 and P < 0.01 defined as statistical significance levels.ResultsThe expression levels of Klf6 (P < 0.01), Dspp (P < 0.05), Dmp1 (P < 0.01), Runx2 (P < 0.01) and Alp (P < 0.01) were significantly elevated during odontoblastic differentiation of iMDP‐3 cells. KLF6 was co‐localized with DSPP, DMP1 and RUNX2 in the cytoplasm and nucleus of iMDP‐3 cells. Overexpression of Klf6 promoted the odontoblastic differentiation of iMDP‐3, whereas the inhibition of Klf6 prevented this procession. Dual‐luciferase assays revealed that Klf6 upregulates Dspp and Dmp1 transcription in iMDP‐3 cells during odontoblastic differentiation.ConclusionKlf6 promoted odontoblastic differentiation by targeting the transcription promoter of Dmp1 and Dspp. This study may offer novel insights into strategies for treating injuries to dental pulp tissue.
Effects of endogenous and exogenous corn protein and its hydrolysates on the structural change and starch digestibility of fried corn starch
Authors: Li Wenhui , Yu Ying , Gong Shengxiang , Zhang Wei , Gu Xinzhe , Wu Jinhong , Wang Zhengwu 
Published: November 2020

SummaryFrying could lead to deformation of starch granules and significant reduction in their internal crystalline structure. All of these changes could lead to rapid digestion of fried starch. The addition of corn protein and its hydrolysate to samples prior to frying can reduce the structural change of the granules and also increase their crystallinity and thermostability. Besides, both corn protein and its hydrolysates showed potent abilities in mitigating starch digestion. The fractions of slowly digestible starch and resistant starch increased significantly after the addition of corn protein or its hydrolysate. Meanwhile, the effect of removal of endogenous protein on fried starch was also examined. The results showed that, after removing the protein, starch granules were severely disintegrated during frying; most importantly, the digestibility of starch was increased significantly. The mitigating effect on corn starch digestion could be attributed to structural changes in the ordered structure and suppression of enzyme activities.
Radio frequency tempering of frozen pacific sauries (Cololabis saira) under batch and continuous mode: Temperature distribution and energy consumption evaluation
Authors: Yao Yao , Zhu Yali , He Jialing , Li Feng , Tang Juming , Koral Tony , Wongsa‐Ngasri Pisit , Jiao Yang 
Published: November 2020

AbstractTo investigate the influences of modes and operating parameters on the radio frequency (RF) tempering uniformity of a pack of frozen pacific sauries, a 27.12 MHz RF equipment was employed for sauries tempering with different input power and electrode gaps under batch and continuous mode. Nine frozen sauries were placed in the RF chamber and tempered under different input power (200, 400, 800, 1,600 W), electrode gaps (7, 8, 9 cm) under batch and continuous tempering mode. With a target end‐point tempering temperature of −4°C. Results showed 200 W/9 cm resulted in the longest tempering time (16.44, 15.43 min) and 1,600 W/7 cm was the shortest (2.95, 3.54 min) under batch mode tempering, respectively. The processing conditions of 200 W/9 cm and 200 W/7 cm under batch mode, and 200 W/8 cm, 200 W/9 cm, 400 W/9 cm, 800 W/8 cm under continuous mode all produced a final sample surface temperature distribution within the range of −10°C to 20°C, which indicated a reasonable tempering process. The area of the high temperature zone (10°C < T ≤ 20°C) of tempered sauries under 200 W/9 cm decreased from 0.28% to 0.23% when switching from batch to continuous mode. This implies that continuous RF tempering could reduce overheating and improve tempering uniformity of sauries.Practical applicationsTempering rate, temperature distribution, and energy consumption are the most important concerns to researchers and the industry since tempering temperature and time are highly correlated to fish product quality. Results in this study showed both batch and continuous mode RF tempering could achieve reasonable tempering effect to a pack of frozen sauries. The application of continuous tempering system is more desirable than the batch ones, which can be applied to the tempering industry with higher throughput and connect to the following continuous processing unit operations. This study will broaden the knowledge of food engineers and provide an alternative technology of aquatic product tempering, and the parameters used in this study can assist technologists for the development of commercial equipment.
Alternative method for the diagnosis of acid cases of unknown cause: Transvaginal natural orifice transluminal endoscopic surgery
Authors: Mat Emre , Kale Ahmet , Yıldız Gazi , Başol Gülfem , Gündogdu Elif C. 
Published: November 2020

AbstractAimTo evaluate the efficacy and reliability of transvaginal natural orifice transluminal endoscopic surgery (vNOTES) technique in making the diagnosis of ascites with unknown cause.MethodsSeven patients with ascites with unknown cause and diagnosed with vNOTES between November 2018 and May 2019 were analyzed retrospectively. The following data were collected retrospectively: body mass index, age, parity, previous abdominal or pelvic surgery, total operating time, perioperative complications and visual analog scale scores for evaluation of postoperative pain. After general anesthesia and disinfection, a 2–3 cm incision was made in the posterior fornix of the vagina. In all of the vNOTES procedures, a handmade glove port system comprised of a glove‐wound retractor NOTES port was used.ResultsTransvaginal natural orifice transluminal endoscopic surgery for diagnostic peritoneoscopy was successfully performed in seven patients. Following postoperative pathological examination; three patients were established to have peritoneal carcinomatosis, one patient abdominal tuberculous, one patient ovarian fibroma, one patient ovarian mature cystic teratoma and one patient stomach cancer. In 1‐year follow‐up period after vNOTES procedure, no adverse events occurred in patients.ConclusionIn making histological diagnosis of ascites with unknown cause, vNOTES is a feasible, safe and efficient technique. Due to its high performance in diagnosis, this technique helps to initiate treatment early in some diseases in addition to preventing unnecessary treatment and examination in benign diseases. Besides, via obtaining a detailed and enlarged image of abdominal cavity, this procedure also guides the clinician in the evaluation of the suitability of patient for operation.
Role of IL‐6 and STAT3 signaling in dihydropyridine‐induced gingival overgrowth fibroblasts
Authors: Lu Sao‐Lun , Huang Chiung‐Fang , Li Chuan‐Li , Lu Hsein‐Kun , Chen Li‐Sheng 
Published: November 2020

AbstractObjectivesThis study analyzed the role of the interleukin (IL)‐6/signal transducer and activator of transcription 3 (STAT3) pathway in dihydropyridine‐induced gingival overgrowth (DIGO) fibroblasts.Materials and methodsTissue samples were obtained through surgical dissection from five DIGO patients and five healthy individuals. Cell cultures were conditioned with nifedipine (Nif) (0.34 µM) and stimulated with IL‐1β (10 ng/ml) to clarify whether IL‐6 upregulates extracellular matrix overproduction or has an impact on the cell proliferation rate of DIGO fibroblasts. STAT3 was knocked down using short hairpin (sh)RNA to determine its role in collagen (Col) type I alpha 1 (Colα1(I)) synthesis.ResultsResults showed that phosphorylated (p)STAT3 nuclear translocation was activated by a simulated autocrine concentration (50 ng/ml) of IL‐6, and application of an anti‐IL‐6 antibody significantly decreased the pSTAT3/STAT3 ratio in DIGO fibroblasts. STAT3 knockdown significantly decreased STAT3 and Colα1(I) expressions in DIGO cells. DIGO tissues presented stronger proliferating cell nuclear antigen (PCNA) expression than did healthy individuals under the effect of IL‐1β/Nif treatment.ConclusionsGingival inflammation (e.g., IL‐1β) and taking dihydropyridine (e.g., Nif) may additively stimulate Col overproduction through the IL‐6−STAT3−Colα1(I) cascade in DIGO cells. IL‐6–STAT3 signaling may be considered a target for the control of DIGO.
Periodontal disorders in a cohort of patients with Cohen syndrome
Authors: Lafon Arnaud , Faivre Laurence , Seux Dominique , Gautier Elodie , Duplomb Laurence , Grogogeat Brigitte , Marcelet Anahide , Laforest Laurent 
Published: November 2020

AbstractAimsCohen syndrome (CS) is an uncommon autosomal recessive disorder due to mutations in vacuolar protein sorting 13B, with an intermittent presence of neutropenia. Contrary to other clinical phenotypic features, oral health has been little investigated in CS. We described oral health and dental hygiene in a cohort of CS patients.Methods and ResultsTwelve CS patients with neutropenia (<1500/mm3) were recruited in the dental department of Dijon University Hospital (France). Patients underwent oral examination, and blood samples were collected. Oral health markers were described and compared between patients with moderate and severe neutropenia (<500/mm3). In 12 patients (mean age = 21.1 years, SD = 13.7, six females), 45.5% brushed at least twice daily their teeth, and the same percentage annually visited a dentist. Dental plaque index was high (mean = 1.7, SD = 1.4). So was the number of lost teeth per patient, notably among adults (mean = 13.8, SD = 9.8). Elevated markers of periodontitis were noted as percentage of bleeding dental sites (mean = 70.2%, SD = 45.2%) or Gingival Index (mean = 2.2, SD = 1.0). The severity of neutropenia was correlated to the level of tooth‐loss (P = .03).ConclusionThis study highlighted in CS patients worrisome oral health and dental follow‐up in the context of intellectual disability with behavioural anomalies. More attention is needed by care‐givers on oral condition in CS.
Are PROMs used adequately in sports research? An analysis of 54 randomized controlled trials with PROMs as endpoint
Authors: Jensen Jonas , Hansen Christian Fugl , Brodersen John , Comins Jonathan D. , Krogsgaard Michael Rindom 
Published: November 2020

Deviations from adequate use and reporting of PROMs may be problematic and misleading. The aim of this study was to investigate the extent of such problems in randomized clinical trials (RCTs). RCTs involving sports medicine research that used PROMs as primary outcomes were identified in 13 preselected journals. The articles were reviewed for nine potential problems related to how the PROM was used and how the data had been reported. The potential problems were as follows: aggregating subscale scores; combining patient‐reported scores with physical, clinical, or para‐clinical measures; using a PROM to diagnose or evaluate the individual patient; using a PROM for one leg or arm; selectively excluding domains or items; constructing a PROM for the specific occasion; mixing PROM formats (ie, digital, paper, telephone, e‐mail, in person); ambiguous instructions for how the PROM should be completed; and recall bias. As covariates, we registered journal impact factor, year of publication, and existence of a registered protocol. In 29 (53.7%) of 54 identified RCTs, at least one potential problem was identified, the most common being aggregation of domain scores. This was not different with a published protocol or dependent on journal rankings, except for exclusion of domains, which was most common in high‐ranking journals. Aggregation of domain scores was significantly less common in recently published articles compared with older articles (P = .03). Potential problematic use of PROMs and reporting of PROM data are common in RCTs, also in high‐ranking journals, but less so in more recent articles.
Educators’ strategies for engaging diverse students in undergraduate nursing education programs: a scoping review protocol
Authors: Iduye Damilola , Vukic Adele , Waldron Ingrid , Price Sheri , Sheffer Catherine , McKibbon Shelley , Dorey Rachel , Yu Ziwa 
Published: November 2020

ABSTRACT

Objective:
The objective of this scoping review is to identify and chart teaching strategies that educators use in classroom settings to engage diverse students in undergraduate nursing education programs.

Introduction:
Student engagement is critical to facilitating academic success and significant learning experiences for undergraduate nursing students. However, students from diverse backgrounds face challenges in undergraduate nursing programs, and these challenges impact their academic engagement and sense of belonging and inclusion. Creating conditions in nursing education that foster engagement by meeting the learning needs of diverse learners could facilitate their success, which ultimately might strengthen the nursing workforce diversity.

Inclusion criteria:
This review will consider papers on how educators engage undergraduate nursing students from diverse backgrounds in classroom settings, including online, face-to-face, and blended formats, irrespective of the country. Evidence obtained from all sources including qualitative, quantitative, and mixed methods studies, systematic reviews, as well as gray literature will be considered for inclusion.

Methods:
JBI methodology for scoping reviews, which includes a three-step search strategy, will be employed. First, keywords will be identified from relevant articles in CINAHL and ERIC. Second, another search using the identified keywords and index terms across select databases will be conducted. Third, the reference lists of all identified articles will be screened for additional papers. Titles and abstracts will be screened by two independent reviewers, and then followed by the full text review of included articles against the inclusion criteria by two independent reviewers. Data will be extracted from included articles and the findings will be presented in tables, figures, and narratively as appropriate.

Scoping review protocol registration:
Open Science Framework https://osf.io/7bv5p/
Prevalence of depression in Latin America and the Caribbean: protocol for a systematic review and meta-analysis
Authors: Errazuriz Antonia , Crisostomo Natalia 
Published: November 2020

ABSTRACT

Objective:
The objective of this review is to evaluate the best available evidence to determine the prevalence of depression in the general population of Latin America and the Caribbean countries.

Introduction:
Depression is a common mental disorder that affects quality of life and has been ranked as the largest contributor to non-fatal health loss. Knowledge of this disorder serves as a relevant instrument for policy makers and for the reassignment of public health resources. Although the prevalence of depression is well documented in high-income countries, little is known about the prevalence in Latin America and the Caribbean.

Inclusion criteria:
This review will include studies that report the prevalence of depression in the general adult (14 years and older) population of countries in Latin America and the Caribbean. Non-representative subsets of the population will be excluded.

Methods:
The search strategy will be designed to obtain both published and unpublished studies. Information sources include PubMed, PsycINFO, Cochrane CENTRAL, and SciELO. Sources of unpublished studies include literature from government departments, international agencies, and academic institution repositories or websites. Eligible studies will be critically appraised for methodological quality. Prevalence estimates will be statistically pooled in a meta-analysis after heterogeneity interpretation; data not appropriate for pooling will be reported in a narrative review. Finally, risk of publication bias will be studied via funnel plot analysis and the Egger test.

Systematic review registration number:
PROSPERO (CRD42019143054)
Competency framework, methods, evaluation, and outcomes of natural disaster preparedness and response training: a scoping review protocol
Authors: Uemura Naoko , Miyazaki Misako , Okuda Hiroko , Haruyama Sanae , Ishikawa Mai , Kim Yoshiharu 
Published: November 2020

ABSTRACT

Objective:
This systematic scoping review aims to clarify and map the range of natural disaster preparedness and response training for public health personnel around the world.

Introduction:
Various preparedness and response training courses, exercises, and drills for public health professionals have been developed for natural disasters. Most of these focus on developing competency. However, there is no overview of the frameworks, methods, evaluation, and outcomes of these disaster preparedness and response training courses, exercises, and drills.

Inclusion criteria:
This review will consider all studies that focus on the framework, evaluation, and outcome of training in natural disaster preparedness for public health personnel.

Methods:
The databases and sources to be searched will include MEDLINE (PubMed), CINAHL with Full Text Plus, Academic Search Premier, APA PsycINFO, and Ichushi-Web. Searches for gray literature will be conducted using websites that discuss, introduce, or provide competence-based disaster preparedness and response training. These websites will mainly be for public organizations or universities with a focus on public health. The review will consider studies published in both English and Japanese. Retrieval of full-text studies and data extraction will be performed independently by two reviewers. The findings will be summarized in tabular form and accompanied by narrative text.