bluuebunny/crossref_metadata_2025_split huggingface dataset:
Observation of magnetic adatom-induced Majorana vortex and its fusion with field-induced Majorana vortex in an iron-based superconductor
Authors: Fan Peng , Yang Fazhi , Qian Guojian , Chen Hui , Zhang Yu-Yang , Li Geng , Huang Zihao , Xing Yuqing , Kong Lingyuan , Liu Wenyao , Jiang Kun , Shen Chengmin , Du Shixuan , Schneeloch John , Zhong Ruidan , Gu Genda , Wang Ziqiang , Ding Hong , Gao Hong-Jun 
Published: September 2020

Abstract
Braiding Majorana zero modes is essential for fault-tolerant topological quantum computing. Iron-based superconductors with nontrivial band topology have recently emerged as a surprisingly promising platform for creating distinct Majorana zero modes in magnetic vortices in a single material and at relatively high temperatures. The magnetic field-induced Abrikosov vortex lattice makes it difficult to braid a set of Majorana zero modes or to study the fusion of a Majorana doublet due to overlapping wave functions. Here we report the observation of the proposed quantum anomalous vortex with integer quantized vortex core states and Majorana zero mode induced by magnetic Fe adatoms deposited on the surface and the realization of its fusion with a nearby field-induced Majorana vortex in iron-based superconductor FeTe0.55Se0.45. We also observe vortex-free Yu-Shiba-Rusinov bound states at the Fe adatoms with a weaker coupling to the substrate, and discover a reversible transition between Yu-Shiba-Rusinov states and Majorana zero mode by manipulating the exchange coupling strength. The dual origin of the Majorana zero modes, from magnetic adatoms and external magnetic field, provides a new single-material platform for studying their interactions and braiding in superconductors bearing topological band structures.
Prognostic value of eight immune gene signatures in pancreatic cancer patients
Authors: Wang Wenting , Xu Zhijian , Wang Ning , Yao Ruyong , Qin Tao , Lin Hao , Yue Lu 
Published: September 2020

Abstract
BackgroundPancreatic cancer is one of the most common malignant tumors of the digestive tract, and it has a poor prognosis. Traditional methods are not effective to accurately assess the prognosis of patients with pancreatic cancer. Immunotherapy is a new promising approach for the treatment of pancreatic cancer; however, some patients do not respond well to immunotherapy, which may be related to tumor microenvironment regulation. In this study, we use gene expression database to mine important immune genes and establish a prognostic prediction model for pancreatic cancer patients. We hope to provide a feasible method to evaluate the prognosis of pancreatic cancer and provide valuable targets for pancreatic cancer immunotherapy.ResultsWe used univariate Cox proportional hazard regression analysis, the least absolute shrinkage and selection operator (LASSO), and multivariate COX regression analysis to screen 8 genes related to prognosis from the 314 immune-related genes, and used them to construct a new clinical prediction model in the TCGA pancreatic cancer cohort. Subsequently, we evaluated the prognostic value of the model. The Kaplan–Meier cumulative curve showed that patients with low risk scores survived significantly longer than patients with high risk scores. The area under the ROC curve (AUC value) of the risk score was 0.755.The univariate COX analysis showed that the risk score was significantly related to overall survival (OS) (HR = 1.406, 95% CI = 1.237 ~ 1.598, P <0.001), and multivariate analysis showed that the risk score was an independent prognostic factor (HR = 1.400 95% CI = 1.287 ~ 1.522, P <0.001). Correlation analysis found that immune genes are closely related to tumor immune microenvironment.Conclusions﻿Based on the TCGA-PAAD cohort, we identified immune-related markers with independent prognostic significance, validated, and analyzed their biological functions, to provide a feasible method for the prognosis of pancreatic cancer and provide potentially valuable targets for pancreatic cancer immunotherapy.
Alternating Hemiplegia of Childhood and Neurological Comorbidities. Variable Intrafamilial Clinical Features.
Authors: Pavone Piero , Pappalardo Xena Giada , Mustafa Naira , Cho Sung Yoon , Jin Dong Kyu , Incorpora Gemma , Falsaperla Raffaele , Marino Simona Domenica , Corsello Giovanni , Parano Enrico , Ruggieri Martino 
Published: September 2020

Abstract
BACKGROUND Alternating Hemiplegia of Childhood (AHC) is an uncommon and complex disorder characterized by age of onset before 18 months, recurrent hemiplegia of one or either sides of the body or quadriplegia. Developmental delay, epilepsy, tonic or dystonic spells, nystagmus and autonomic manifestations are frequently reported manifestations. AHC is mainly caused by mutations in ATP1A3 gene, and to a lesser extent in ATP1A2 gene.CASE PRESENTATION Clinical and genetic findings of a couple of twins and a couple of siblings affected by AHC from two different Italian families were deeply examined. Intrafamilial clinical variability was shown in the present cases. A pathogenic variant rs606231437 in ATP1A3 gene was detected in twins, while in one of the siblings was found a novel variant of GRIN2A (c.3175T>A) gene, shared by the other brother who also had a variant in SCN1B (c.632G>A) and KCNQ2 (c.1870G>A) genes.CONCLUSIONS Developmental delay, epileptic seizures and motor dysfunction are features frequently associated to paroxysmal hemiplegic attacks. Hemiplegic episode is only a sign even if the most remarkable of several neurological comorbidities in AHC carriers. Therefore, we suggest that the view of the disorder should be greatly changed to the term “AHC spectrum disorder". The comparison of molecular analysis among the four probands brings out how the genetic framework is not recurrent, but may result from an unexpected greater genetic heterogeneity, such as seen in siblings carrying a new set of gene variants implicated in channelopathies likely to be eligible as further risk factors for AHC.
Machine learning approaches to the determinants of women’s vasomotor symptoms using general hospital data
Authors: Ryu Ki-Jin , Yi Kyong Wook , Kim Yong Jin , Shin Jung Ho , Hur Jun Young , Kim Tak , Seo Jong Bae , Lee Kwang-Sig , Park Hyuntae 
Published: September 2020

Abstract
Background

To analyze the determinants of women’s vasomotor symptoms (VMS) using machine learning.
Methods

Data came from Korea University Anam Hospital in Seoul, Korea, with 3298 women, aged 40–80 years, who attended their general health check from January 2010 to December 2012. Five machine learning methods were applied and compared for the prediction of VMS, measured by a Menopause Rating Scale. Variable importance, the effect of a variable on model performance, was used for identifying major determinants of VMS.
Results

In terms of the mean squared error, the random forest (0.9326) was much better than linear regression (12.4856) and artificial neural networks with one, two and three hidden layers (1.5576, 1.5184 and 1.5833, respectively). Based on variable importance from the random forest, the most important determinants of VMS were age, menopause age, thyroid stimulating hormone, monocyte and triglyceride, as well as gamma glutamyl transferase, blood urea nitrogen, cancer antigen 19 − 9, C-reactive protein and low-density-lipoprotein cholesterol. Indeed, the following determinants ranked within the top 20 in terms of variable importance: cancer antigen 125, total cholesterol, insulin, free thyroxine, forced vital capacity, alanine aminotransferase, forced expired volume in one second, height, homeostatic model assessment for insulin resistance and carcinoembryonic antigen.
Conclusions

Machine learning provides an invaluable decision support system for the prediction of VMS. For preventing VMS, preventive measures would be needed regarding the thyroid function, the lipid profile, the liver function, inflammation markers, insulin resistance, the monocyte, cancer antigens and the lung function.
Telehealth Consultations in General Practice During a Pandemic Lockdown: Survey and Interviews on Patient Experiences and Preferences
Authors: Imlach Fiona , McKinlay Eileen , Middleton Lesley , Kennedy Jonathan , Pledger Megan , Russell Lynne , Churchward Marianna , Cumming Jacqueline , McBride-Henry Karen 
Published: September 2020

Abstract
BackgroundDuring the first COVID-19 pandemic ‘lockdown’ in Aotearoa/New Zealand (March-May 2020, in which strict ‘stay at home’ measures were introduced), general practices were advised to use telephone and video consultations (telehealth) wherever possible instead of the usual in-person visits. This was a sudden change for most practices and patients. This research aimed to explore how patients accessed general practice during lockdown and evaluate their experiences with telehealth, to inform how telehealth could be most effectively used in the future. MethodsUsing a mixed-method approach, we undertook an online survey and in-depth interviews with adults (>18 years) who had contact with practices during lockdown, recruited through social media and email lists. We present descriptive statistics from the survey data (n=1,010) and qualitative analysis of interview data (n=38) and open-ended survey questions, using a framework of access to health care, from the patient’s perspective.ResultsIn general, patients reported high satisfaction with telehealth in general practice during lockdown. Telehealth was convenient and allowed patients to safely access health care without having to weigh-up the fear of COVID-19 infection against the need to be seen. Telehealth worked best for routine and familiar health issues and when rapport was established between patients and clinicians. This was easier with a pre-existing clinical relationship, but not impossible without one. Telehealth was less suitable when a physical examination was needed, when the diagnosis was unknown or for patients who had a strong preference to be seen in-person. ConclusionsEven in this disruptive lockdown period, that prompted an unexpected and rapid implementation of telehealth services in general practices, most patients had positive experiences with telehealth. In the future, patients want the choice of consultation type to match their needs, circumstances, and preferences. Technological issues and funding barriers may need to be addressed, and clear communication for both patients and clinicians is needed about key aspects of telehealth (e.g. cost, appropriateness, privacy). Maintaining telehealth as an option post-lockdown has the potential to increase timely and safe access to primary health care for many patients.
Assessing the Effect of Virtual Education on Information Literacy Competency for Evidence-based Practice of the Undergraduate Nursing Students&nbsp;
Authors: Shamsaee Maryam , Magholian Parvin , Ahmadian Leila , Farokhzadian Jamileh , Fatehi Farhad 
Published: September 2020

Abstract
Background: Information literacy is one of the important prerequisites for an effective evidence-based practice (EBP). Therefore, it is necessary to pay attention to curricular development and use new educational methods such as virtual education to strengthen information literacy competency in nursing students. This study investigated the effect of virtual education on nursing students’ information literacy competency for EBP.Methods: This interventional study was performed with two groups of intervention and control and a pretest and posttest design. Seventy-nine nursing students were selected and assigned into the intervention or control groups by random sampling. Virtual education of the information literacy was uploaded on a website in the form of seven modules delivered in four weeks. Questionnaires of demographic information and information literacy for EBP were used to collect data before and one month after the virtual education.Results: The results showed no significant difference between the control and intervention groups in all dimensions of information literacy competency in the pre-test stage. In the post-test, the virtual education improved some dimensions of information literacy competency for EBP including information seeking skills (t= 3.144, p= 0.002) and knowledge about search operators (t= 39.84, p= 0.001) in the intervention groups compared with the control group. Virtual education of the information literacy did not have any significant effect on nursing students in terms of use of different information resources and development of search strategy and frequency of the correct answer to the question of formulating a search strategy in intervention group (p>0.05). Conclusion: Virtual education had a significant effect some demotions of the information literacy competency for EBP in nursing students. Nursing professors and educators are recommended to train information literacy by integrating virtual and face-to-face education. Researchers should also examine the effectiveness of these interventions, their barriers and facilitators.
Prevalence and Factors Associated With HIV Self-testing Uptake Among Men Who Have Sex With Men in Ningbo, China: A Cross-sectional Study
Authors: Hong Hang , Shi Hong-bo , Jiang Hai-bo , Dong Hong-jun , Shen Yun-liang 
Published: September 2020

Abstract
BackgroundHIV testing and early linkage to care are critical for reducing the risk of HIV transmission. HIV self-testing (HIVST) is an useful tool for increasing HIV testing frequency.This study aimed to investigate HIVST rates among men who have sex with men (MSM), the characteristics of MSM who had HIVST, and factors associated with HIVST uptake among MSM in Ningbo, China. MethodsA cross-sectional study was conducted from April to October 2019 in Ningbo,China. Participants were aged at least 18 years and having had sexual contact with men in the past year. Proportions were used for categorical variables. Adjusted Odds Ratio (AOR) and 95% Confidence Interval (CI) for characteristics associated with HIVST uptake was processed by multiple logistic regression models.ResultsAmong a sample of 699 MSM recruited, 38.2% had reported previous use of an HIV self-test kit. A greater proportion of HIVST Users had a higher frequency of HIV testing(≥2 times: 70.0% versus 41.2%, p<0.001) in the past one year. Factor associated with HIVST uptake was gay apps use(AOR=1.86,CI=1.13-3.05), multiple male sex partners (AOR=1.90,CI=1.29-2.80), frequency of male-male sexual contact ≥1 times per week(AOR=1.86, CI=1.30-2.66), syphilis infection(AOR=5.48, CI=2.53-11.88).ConclusionsFurther HIVST education should be strengthened for school-aged children and teenagers, and free HIVST kits may be provided to low-income high-risk MSM through gay apps and NGOs to achieve the increased HIV testing frequency.
Emodin Improves Glucose and Lipid Metabolism Disorders in Obese Mice via Activating Brown Adipose Tissue and Inducing Browning of White Adipose Tissue
Authors: Cheng Long , Zhang Shuofeng , Shang Fei , Sun Jianning , Dong Shifen 
Published: September 2020

Abstract
Background: Obesity has become a worldwide health threat related to type 2 diabetes, hypertension, cardiovascular disease, etc. Activating brown adipocytes and inducing browning of white adipocytes has been proposed as a potential molecular target for obesity treatment. In the present study, we investigated the effects of emodin on browning in mice with high-fat diet (HFD) and explore its underlying pharmacological mechanisms. Methods: The positive effects of emodin (40, 80 mg/kg/day, i.g. for 6 weeks) on lipid metabolism were evaluated in mice model of hyperlipidemia. Hyperlipidemia mice were induced by high-fat diet (60% of kilocalories from fat, 5.24 Kcal/kg) for 8 weeks. Body weight and food intake were monitored every week. After 6 weeks of treatment, fasting blood glucose, oral glucose tolerance, Lee's index, the ratio of fat weight to body weight, blood lipids, and adipose tissues morphology were assayed. Then uncoupling protein 1 (UCP1), CD36, fatty acid transporter 4 (FATP4), peroxisome proliferator activated receptor α (PPARα) and prohibitin (PHB) protein of subcutaneous white adipose tissue (scWAT) and brown adipose tissue (BAT) were analyzed. In addition, the lipid metabolites in adipose tissues were analyzed by ultra-high- performance liquid chromatography with electrospray ionization tandem mass spectrometry.Results: Emodin treatment decreased body weight gain, fasting blood glucose, Lee's index, the ratio of scWAT weight to body weight, and the levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-c) and Leptin in serum, and increased serum adiponectin content and improved glucose tolerance. Furthermore, emodin enhanced the expression of UCP1, CD36, FATP4, PPARα and PHB protein in scWAT and BAT. Meanwhile, emodin can significantly up-regulated lipid levels in scWAT of mice fed with HFD such as PC(O-18:2/22:5), PE(O-18:1/18:2), PE(O-18:2/20:4), PE(O-20:1/20:5), Cer(d14:1/20:0) and SM(d18:0/23:0), and reduced the lipid levels such as PC(O-18:0/20:0), PE(O-18:2/22:2), PE(O-18:0/22:5). In addition, emodin significantly up-regulate lipid levels in BAT of mice fed with HFD such as PC(14:0/16:0), PC(16:0/16:1), PC(16:1/16:1), PC(15:1/18:3), PC(18:0/20:0), LysoPC(20:0), LysoPC(22:0) and LysoPC(22:1), and reduced the lipid levels PC(12:0/20:4) and PC(17:0/22:5). Conclusions: These results indicated that hyperlipidemia could be alleviated by treatment of emodin via promoting browning of white adipose tissue. In addition, the disturbance of some small lipid metabolites in adipose also could be reversed by emodin.
Selenide Chitosan Sulfate Improved The Hepatocyte Activity, Growth Performance, and Anti-Oxidation Ability by Activating The Thioredoxin Reductase of Chickens In Vitro and In Vivo
Authors: Hou Lele , Qiu Huiling , Zhu Lianqin , Huang Yufeng , Gao Shansong , Chen Fu 
Published: September 2020

Abstract
Background: There are very few studies on the synergy effects of biological antioxidant activity on selenium (Se) and sulfate. This study evaluated the effect of selenide chitosan sulfate (LS-COS-Se) on the hepatocytes activity, growth performance, and anti-oxidation ability by activating the thioredoxin reductase (TrxR) system of specific pathogen free (SPF) chickens in vitro and in vivo. Methods: The hepatocytes were obtained in vitro and a total of 240 SPF White Leghorns chickens (7 days of age and body weight of 45.0 ± 2.0 g) were collected in vivo. The hepatocytes and chickens were randomly allocated into six treatment groups: control group; chitosan (COS) group; sodium selenite (Na2SeO3) group; selenide chitosan (COS-Se) group; chitosan sulfate (LS-COS) group; LS-COS-Se group. After 24 h, the culture medium and hepatocytes were collected and preserved respectively for analyzing the metabolic activity of hepatocytes. Gowth performance was evaluated and chickens were euthanized to obtain plasma and liver tissue to measure antioxidant associated parameter on days 14 and 28. Results: The experiment in vitro showed that the activities of TrxR, superoxide dismutase (SOD), catalase (CAT) in culture medium and the levels of thioredoxin reductase 1 (TrxR-1) and thioredoxin reductase 3 (TrxR-3) mRNA in hepatocytes in LS-COS-Se group were significantly higher (P < 0.05), but the content of malondialdehyde (MDA) and the activity of lactate dehydrogenase (LDH) significantly decreased (P < 0.05) than those in control, COS and LS-COS groups. Compared with Na2SeO3 and COS-Se groups, the levels of TrxR-1 and TrxR-3 mRNA in hepatocytes and the activity of SOD in culture medium significantly increased in LS-COS-Se group (P < 0.05). The experiment in vivo showed that the baby weight on 14d and 28d, the activities of TrxR, SOD and anti-superoxide anion radical (AntiO2-) in plasma and the levels of TrxR-1 and TrxR-3 mRNA in liver of dietary supplementation with LS-COS-Se were significantly higher than those in control, COS and LS-COS groups (P < 0.05). The activities of TrxR and SOD in plasma of dietary supplementation with LS-COS-Se were significantly higher than those of Na2SeO3 group and COS-Se group (P < 0.05). Conclusion: LS-COS-Se as potential antioxidant improved the hepatocytes activity, growth performance, and anti-oxidation ability by activating the TrxR system of SPF chickens in vitro and in vivo. The better biological activity of LS-COS-Se was mainly due to the synergistic effect of Se and sulfate on TrxR system.
Organizational Norms and Leadership Effectiveness: Do the Leader's Innovative Behavior and Knowledge Sharing Intention Matter?
Authors: Belete Aselefech , Tufa Tesfaye Leta 
Published: September 2020

Abstract
Even though organizations are failing because of leadership ineffectiveness, there is no consensus on the secret behind leadership effectiveness. Therefore, this study is aimed to investigate the role of subjective organizational norms on leadership effectiveness with a specific contribution from a leader’s innovative behavior, knowledge sharing intention, and autonomy. To achieve this, I analyzed data collected from 104 Ethio Telcom employees using the ordinary least square (OLS) regression and hierarchical regression analysis. The result of the OLS regression revealed that organizational norms influence leadership effectiveness indirectly through a leader’s innovative behavior. This relationship is intensified when the leader is intended to share knowledge more. Moreover, the presence of high autonomy among leaders leads to the development of innovative behavior among those leaders, which further improves the effectiveness of leaders. Besides the above findings, future researchers should compare and contrast the above relationship among the leaders and employees. They should also test the role of other entrepreneurial variables such as risk-taking and proactiveness concerning leadership effectiveness.
Synergistic mechanism of basic medical insurance and public health policy under major public crisis
Authors: He Wei , liu Huan , Hu Tiantian 
Published: September 2020

Abstract
Background

The coordinated development of the basic medical insurance system and public health is not only related to the structural soundness of the entire country’s medical and health system, but also related to a country’s initiative in responding to major public health events.
Methods

This article attempts to endogenously implement health care policies in the health production function, and from the perspective of health benefits, attempts to build a theoretical analysis of framework for the coordinated development of basic medical insurance and public health, revealing the benignly interactive circulation mechanism of the health care system and improving the health benefits of individuals and society realistic path.
Results

In the field of medical and health services, the establishment of a benign medical and health investment system can promote the improvement of the level of health output and the improvement of the health effectiveness of individuals and society, and thus promote the increase of social and individual health and welfare levels; and promote a virtuous cycle of overall healthy reproduction.
Conclusions

Under the synergy mechanism, the basic medical insurance policy and public health policy during the new coronary pneumonia should meet the synergy standards. Scientific and reasonable medical and health service policies should not only consider the treatment of new coronary pneumonia patients and group prevention and control, but also pay attention to the coordination of basic medical insurance policies and public health policies, and the coordination of health production and health benefits. The core of policy coordination is to protect both patients with new coronary pneumonia and the general medical and health services of residents.