bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Bayesian Latent Class Mixture Model With Censoring for Correlation Analysis in Antimicrobial Resistance Across Populations
Authors: Zhang Min , Wang Chong , O'Connor Annette 
Published: October 2020

Abstract
Background: The emergence of antimicrobial resistance across populations is a global threat to public health. Surveillance programs often monitor human and animal populations to evaluate trends of emergence in these populations. Many national level antibiotic resistance surveillance programs quantify the proportion of resistant bacteria as a means of monitoring emergence and control measures. The reason for monitoring these different populations are many, including interest in similar changes in resistance which might provide insight into emergence and control options. Methods: In this research, we developed a method to quantify the correlation in antimicrobial resistance across populations, for the conventionally unnoticed mean shift of the susceptible bacteria. With the proposed Bayesian latent class mixture model with censoring and multivariate normal hierarchy, we address several challenges associated with analyzing the minimum inhibitory concentration data. Results: Application of this approach to the surveillance data from National Antimicrobial Resistance Monitoring System led to a detection of positive correlation in the central tendency of azithromycin resistance of the susceptible populations from Salmonella serotype Typhimurium across food animal and human populations. Conclusions: Our proposed approach has been shown to be accurate and superior to the naïve frequentist estimation by simulation studies. Further implementation of this Bayesian model could serve as a useful tool to indicate the co-existence of antimicrobial resistance, and potentially a need of clinical intervention.
Mental Health and Sleep Habits/Problems in Children at 3–4 Years of Age: A General Population Study
Authors: Horiuchi Fumie , Kawabe Kentaro , Oka Yasunori , Nakachi Kiwamu , Hosokawa Rie , Ueno Shu-ichi 
Published: October 2020

Abstract
Background: Sleep is essential for mental health at all ages, but few studies have investigated the importance of sleep for mental health in early childhood. Therefore, this study examined the association between mental health and sleep habits/problems in children at 3-4 years of age. Methods: Children aged 3 to 4 years who were living in the community (n = 415; 211/204 boys/girls) were recruited in this study. Their mental health was assessed using the Strengths and Difficulties Questionnaire (SDQ), and their sleep habits/problems were evaluated using the Child and Adolescent Sleep Checklist. Results: Based on the total difficulties score of the SDQ, the children were divided into two groups: a poor mental health group (n = 76) and a control group (n = 339). In terms of sleep habits, which included total sleep time, bedtime, wake time, and nap conditions, there were no differences between the two groups. Regarding sleep-related problems, however, anxiety before going to sleep (p = 0.026), abnormality in the circadian rhythm (p = 0.014), and sleepiness during classes outside of naptimes (p = 0.031) were significantly higher in the poor mental health group than in the control group. Multiple regression analysis showed that poor mental health status was significantly associated with sleepiness and snoring (p = 0.017 and p = 0.018, respectively). Conclusions: The mental health status of 3-year-old children is associated with sleep-related problems, namely sleepiness and snoring. Healthcare providers should pay attention to children’s irregular sleep-wake patterns; moreover, interventions for appropriate sleep hygiene will reduce the psychological burden on both children and their families.
Identification of a Prognostic Signature of Malignant Melanoma Based on Tumor Immune Microenvironment Exploration
Authors: yuan lingyan , Bing Zhitong , Wang Jianshu , Li Jing , Jin Xiaodong , Li Rui , Wang Caiyun , Sun Xueqiang , Yang Lei , Yang Kuhu 
Published: October 2020

Abstract
Background: In contrast to identification of well-defined oncogenic alterations like BRAF mutations for malignant melanoma (MM) patient stratification, effective selection of predictive biomarkers remains a challenge in the era of checkpoint blockade.Methods: The differentially expressed genes (DEGs) related to the TME were identified using The Cancer Genome Atlas (TCGA) dataset by Wilcoxon rank sum test. The prognostic effects of immune-related genes (IRGs) were analyzed using univariate Cox regression. Next, the prognostic model was constructed by step multivariate Cox regression and risk score of each sample was calculated. Then, survival and Receiver Operating Characteristic (ROC) analyses were conducted to validate the model using TCGA and the Gene Expression Omnibus (GEO) datasets, respectively. Finally, the overall immune status, tumor purity of high- and low-risk groups was further analyzed to reveal the potential mechanisms of prognostic effects of the model.Results: Twenty eight IRGs were identified, the univariate cox analysis indicated the hazard ratio ranged from 0.796 to 2.621 (p-value < 0.05). 6 genes (SLPI, S100A7, LYZ, CCL19, CXCR4 and CD79A) were screened out by step multivariate cox regression and a 6-IRGs, which can be used as an independent prognostic factor, was constructed. The MM patients in both training (TCGA) and testing (GEO) datasets can be well stratified as high-risk and low-risk groups with the 6-IRGs signature, and the 3-year and 5-year area under curve (AUC) of ROC curves of GEO set were 0.681 and 0.678 (GSE19234). Conclusions: In sum, we identified and constructed a 6-IRGs , which can be used to predict the prognosis of metastasis in MM patients.
Point-of-care Cerebrospinal Fluid Gram Stain For the Management of Acute Meningitis in Adults: A Retrospective Observational Study
Authors: Taniguchi Tomohiro , Tsuha Sanefumi , Shiiki Soichi , Narita Masashi 
Published: October 2020

Abstract
Background: Gram staining of cerebrospinal fluid (CSF) is widely used in the diagnosis of acute meningitis, but is often conducted in the laboratory, as only some hospitals have access to point-of-care Gram stain (PCGS). The purpose of this study was to demonstrate the clinical impact and utility of PCGS in diagnosing and treating both bacterial and aseptic meningitis in adults. Methods: This was a hospital-based, retrospective observational study at a referral center in Okinawa, Japan. We reviewed the records of all patients aged 15 years or older who were admitted to the Division of Infectious Diseases between 1995 and 2015 and finally diagnosed with bacterial (n=34) or aseptic meningitis (n=97). For bacterial meningitis, we compared the treatments that were actually selected based on PCGS with simulated treatments that would have been based on the Japanese guidelines. For aseptic meningitis, we compared the rates of antibiotic use between real cases where PCGS was available and real cases where it was not. Results: PCGS was the most precise predictor for differentiating between bacterial and aseptic meningitis (sensitivity 91.2%, specificity 98.9%), being superior in this regard to medical histories, vital signs and physical examinations, and laboratory data available in the emergency room. In bacterial meningitis, PCGS reduced the frequency of meropenem use (1/34=3.0%) compared with simulated cases in which PCGS was not available (19/34=55.9%) (p=0.000). In real aseptic meningitis cases, the rate of antibiotic administration was lower when PCGS was used (38/97=39.2%) than when it was not (45/74=60.8%) (p=0.006). Conclusions: PCGS of CSF distinguishes between bacterial and aseptic meningitis more accurately than other predictors available in the ER. Patients are more likely to receive narrower-spectrum antimicrobials when PCGS is used than when it is not. PCGS of CSF thus can potentially suppress the empiric use of antimicrobials for aseptic meningitis.
Treatment of Acute Acquired Concomitant Esotropia
Authors: Shi Minghua , Zhou Yuanxiang , Qin Aijiao , Chen Jing , Ren Hongxing 
Published: October 2020

Abstract
Background: The treatment efficacy of botulinum toxin bilateral medial rectus injections for acute acquired concomitant esotropia (AACE) in adult is not clear. We characterize the effects of botulinum toxin injection in the treatment of AACE, especially in patients over 14 years old,and compared it with surgical treatment.Methods: In this prospective, nonrandomized, controlled clinical study, patients with AACE in our hospital from March 2017 to March 2020 elected to receive bilateral medial rectus injections of botulinum toxin or to undergo extraocular muscle surgery. Ocular position and stereopsis were evaluated before and after treatment.Results: A total of 60 patients were treated: 40 patients in the botulinum toxin group, and 20 patients in the surgery group. The botulinum toxin group included 31 cases ≥14 years of age and 9 cases <14 years of age. After 1–3 botulinum injections, the cumulative initial success rate was 95% (38/40), and the recurrence rate was 22.5% (9/40). Nine children <14 years of age were treated successfully, without recurrence. In the surgery group, the initial success rate after surgery was 75% (17/20), and the recurrence rate was 20% (4/20). There was no significant difference between groups in the rate of success rate or the rate of recurrence (P>0.05).Conclusion: The injection of botulinum toxin has a good effect on AACE in adults with minimal squinting and in children. The outcomes achieved with injected botulinum toxin are similar to those achieved with surgery.Trial registration: ChiCTR, ChiCTR2000032544. Registered May 2, 2020，Retrospectively registered, http://www.chictr.org.cn/showproj.aspx?proj=52349
Primary Gastroduodenal Tuberculosis Complicated With Acute Pancreatitis: A Rare Case Report and Literature Review
Authors: Li Yuanhua , Liao Suhuan , Zuo Haijun , Yang Wei , Jiang Di 
Published: October 2020

Abstract
Background: Tuberculosis (TB) is a major health problem worldwide. Even in highly prevalent countries, primary gastroduodenal tuberculosis is a rare manifestation of extrapulmonary tuberculosis. In recent years, as the incidence of tuberculosis has increased year by year, the occur of gastroduodenal tuberculosis has also increased. Endoscopy is an important tool for diagnosing gastroduodenal tuberculosis. The performance of gastroduodenal tuberculosis under endoscopy is often non-specific, which may imitate other benign or malignant gastroduodenal diseases. Diagnosis of gastroduodenal tuberculosis relies on a combination of endoscopy and guided biopsy. Case presentation: Here, we report a rare and interesting case of gastroduodenal tuberculosis with acute pancreatitis. The case initially mimicked gastroduodenal ulcers in morphology and appeared in a middle-aged person with normal immunity but with prolonged fever and abdominal pain. The disease was diagnosed through endoscopy and guided biopsy, and it responded well to antituberculosis drugs. Conclusions: Clinicians must remember that even in the absence of immunodeficiency, as in this case, tuberculosis can affect any part of the gastrointestinal tract.
Y-shaped Ventriculo-peritoneal Shunt for Adult Complicated Hydrocephalus: Report of 28 Illustrative Cases
Authors: Ren Xiaohui , Yang Chuanwei , Li Xiangrong , Wang Yonggang , Lin Song 
Published: October 2020

Abstract
ObjectiveTo investigate the effectiveness of Y-shaped ventriculo-peritoneal shunt (VPS) (one abdominal tip connected with double or triple ventricular tips by one or two Y-shaped connectors) in the treatment of adult complicated hydrocephalus, we analyzed the long-term outcome and reported some illustrative cases.MethodsAmong 1,100 VPS surgeries between 2012 and 2017 in neurosurgery of Beijing Tiantan Hospital, twenty-eight (2.5%) adult patients with multiloculated hydrocephalus treated with Y-shaped shunt were analyzed.ResultsNineteen patients underwent Y-shaped VPS (bilateral frontal horn shunt) before or without tumor resection/stereotactic biopsy, 7 patients underwent Y-shaped VPS after tumor resection (5 bilateral and 2 triple shunts), and the other 2 patients underwent sequential bilateral VPS (unilateral VPS with additional contralateral ventricular tip by Y-shaped connector 6 months later). The one-year and two-year hydrocephalus-free survival rate for was both 88.7%. The one-year and two-year overall survival rate was both 66.7%. Cox regression confirmed that the OS is correlated with tumor grades. ConclusionsY-shaped VPS strategy is an easy and reliable option for multiloculated hydrocephalus, which can be used as the first choice for some indications.
Development of an Intervention to Support Reproductive Health of Garment Factory Workers in Cambodia
Authors: Smith Chris , Sokhey Ly , Tijamo Camille , McLaren Megan , Free Caroline , Watkins Justin , Amra Ou , Masuda Chisato , Williamson Amy , Oreglia Elisa 
Published: October 2020

Abstract
Background: Garment factory workers in Cambodia are potentially a vulnerable population in terms of support for reproductive health issues and access to services, as the majority are young women aged under 30 years who have migrated from rural areas away from their family and community support. The aim of this paper was to describe the development of an intervention to support the reproductive health of garment factory workers in Cambodia.Methods: The research was conducted by a multidisciplinary team with backgrounds in public health, linguistics, digital cultures and service delivery in a suburb of Phnom Penh where many garment factories cluster. Informed by intervention mapping approaches, we conducted a needs assessment with general and participant observation and semi-structured interviews, followed by intervention development activities including specifying possible behaviour change, designing the intervention and producing and refining intervention content.Results: Our research identified some challenges that Cambodian garment factory workers experience regarding contraception and abortion. Concerns or experience of side-effects were identified as an important determinant leading to non-use of effective contraception and subsequent unintended pregnancy. Financial constraints or a desire to space pregnancies were the main reported reasons to seek an abortion. Information about medical abortion given to women by private providers was often verbal, with packaging and the drug information leaflet withheld. Given the observed widespread use of social media among factory workers, we developed three short ‘edutainment’ videos about contraception which were evaluated after one month. In addition we adapted three informative videos made by Marie Stopes International (MSI) from English to the Khmer language, and also adapted the MSI medical abortion ‘Mariprist’ instruction leaflet to a simple video format.Conclusions: We describe the development of an intervention to support reproductive health among garment factory workers in Cambodia. These videos could be further improved and additional videos could be developed. More work is required to develop appropriate and effective interventions to support reproductive health of garment factory workers in Cambodia.
Composition of phenolic compounds in gasification wastewater
Authors: yuan zhao 
Published: October 2020

Abstract
The crude phenol was used as raw material, which was extracted by organic solvent from wastewater of typical fixed bed gasification process. The distillation range of raw materials was analyzed. According to the results of distillation range analysis, the wide and narrow fractions of raw materials were cut by using real boiling point distillation device. The method of derivatization pretreatment combined with gas chromatography external standard was used for qualitative and quantitative analysis of phenolic compounds in different fractions. The results showed that the yield of the fraction below 290 ℃ was 68.50% (mass fraction), in which 33 kinds of effective phenolic compounds could be identified, and the total amount of identified phenols was nearly 80%. The content of eight phenolic compounds was relatively high, among which the content of phenol was the highest (26.34%) , followed by catechol 13.44%. Among these phenolic compounds, the content of the remaining six phenols ranged from 4 to 8%, the total content of m-cresol and p-cresol was more than 12%, and the content of 5-indenol was nearly 8%. The yield of the fraction rich in low-grade phenol below 230 ℃ was 35.40%, in which the content of phenol was more than 40%, the total content of cresol was more than 23%, and the total content of m-cresol and p-cresol was nearly 20%. At room temperature, the fractions of 235 ~ 245 ℃ and 245 ~ 260 ℃ were white crystals, in which catechol content was about 50%, and 5-indenol content was more than 10%. The content of these two phenolic compounds with high added value was low in typical coal tar, so it was difficult to extract them. However, they could be enriched in gasification wastewater by water selection due to their strong polarity and good water solubility, which made it possible for them to be further extracted.
A Triple-Correlation Framework for Demonstrating an Innovative Gas Warning System: A Case Study in China
Authors: wu robert , Fan Jianfeng , Yan Wanjun , Shen Bo , Soar Jeffrey , Gou Jinwen , Liu Bao , Zhang Zhongwu , Gide Ergun , Huo Wenying , Wang Peilin , Peng Zhanfei , Wang Ya 
Published: October 2020

Abstract
This research aims to develop an innovative gas warning system for improving production safety in the underground coal mining industry. Coal mining is an important sector for China’s economic development; gas monitoring systems are widely adopted as almost 60% of coal mining accidents are caused by gas. Existing gas monitoring systems mainly focus on simply detecting real-time data obtained from gas sensors. The literature review did not find gas monitoring systems that provide alarms or warnings from the correlation of gas with data from other sensors. This research aims to fill this gap to uncover hidden patterns and correlations between gas and temperature, wind, and dust, and incorporate data analytics into developing an innovative, integrated gas warning system. Correlational research was adopted using 328,320 data outputs obtained from ZhongXing Co. Ltd in Dec 2019. The study found strong relations between gas and temperature, wind, and dust. A Triple-Correlation Theoretical Framework and a Unified Modeling Language (UML) model were developed for an innovative gas warning system. As a result of this research, the ZhongXing Innovative Gas Warning System was developed and deployed for user acceptance testing on 28 Aug 2020.
P-V-Tmeasurements of Fe3C to 117 GPa and 2100 K: Implications for stability of Fe3C phase at core conditions
Authors: McGuire Chris , Komabayashi Tetsuya , Thompson Samuel , Bromiley Geoffrey , Ishii Takayuki , Greenberg Eran , Prakapenka Vitali B. 
Published: October 2020

AbstractWe report the thermal Equation of State (EoS) of the non-magnetic Fe3C phase based on in situ X-ray diffraction (XRD) experiments to 117 GPa and 2100 K. High-pressure and temperature unit-cell volume measurements of Fe3C were conducted in a laser-heated diamond-anvil cell. Our pressure-volume-temperature (P-V-T) data together with existing data were fit to the Vinet equation of state with the Mie-Grüneisen-Debye thermal pressure model, yielding V0 = 151.6(12) Å3, K0 = 232(24) GPa, K0′= 5.09(46), γ0 = 2.3(3), and q = 3.4 (9) with θ0 = 407 K (fixed). The high-T data were also fit to the thermal pressure model with a constant αKT term, PTh = αKT(ΔT), and there is no observable pressure or temperature dependence, which implies minor contributions from the anharmonic and electronic terms. Using the established EoS for Fe3C, we made thermodynamic calculations on the P-T locations of the breakdown reaction of Fe3C into Fe7C3 and Fe. The reaction is located at 87 GPa and 300 K and 251 GPa and 3000 K. An invariant point occurs where Fe, Fe3C, Fe7C3, and liquid are stable, which places constraints on the liquidus temperature of the outer core, namely inner core crystallization temperature, as the inner core would be comprised by the liquidus phase. Two possible P-T locations for the invariant point were predicted from existing experimental data and the reaction calculated in this study. The two models result in different liquidus “phases” at the outer core-inner core boundary pressure: Fe3C at 5300 K and Fe7C3 at 3700 K. The Fe7C3 inner core can account for the density, as observed by seismology, while the Fe3C inner core cannot. The relevance of the system Fe-C to Earth’s core can be resolved by constructing a thermodynamic model for melting relations under core conditions as the two models predict very different liquidus temperatures.
Heat capacity and thermodynamic functions of partially dehydrated sodium and zinc zeolite A (LTA)
Authors: Dickson Matthew S. , Rosen Peter F. , Neilsen Grace , Calvin Jason J. , Navrotsky Alexandra , Woodfield Brian F. 
Published: October 2020

Abstract
Zeolite A (LTA) is an industrially important zeolite that exhibits sorption-induced framework flexibility, the thermodynamics of which are poorly understood. In this work, we report heat capacity measurements on zinc and sodium zeolite A from 1.8 to 300 K and compare the heat capacity of water in sodium zeolite A with that of water in other zeolites. The heat capacity of zeolitic water varies significantly depending on the hydration level and identity of the host zeolite, and more tightly bound water exhibits strong inflections in its heat capacity curve. This suggests a combination of effects, including differences in water-framework binding strength and hydration-dependent flexibility transitions. We also report fits of the heat capacity data using theoretical functions, and we report values for CP,m∘,Δ0TSm∘,Δ0THm∘, and Φm∘ from 0 to 300 K. These results contribute to a systematic thermodynamic understanding of the effects of cation exchange, guest molecule confinement, and sorbate-dependent flexibility transitions in zeolites.
Modern aspects of the pathogenesis and treatment of dyspepsia
Authors: Tsukanov V. V. , Vasyutin A. V. , Tonkikh Ju. L. 
Published: October 2020

A review of current data suggests that the attention to the problem of dyspepsia is huge. The definition of functional dyspepsia was given in the Rome IV criteria, according to which two of its main options are distinguished – epigastric pain syndrome and postprandial distress syndrome. The term “uninvestigated dyspepsia” is important, which means the presence of dyspepsia symptoms in patients who have not performed diagnostic procedures to identify the organic causes of the pathology. The prevalence of uninvestigated dyspepsia in the world is about 21%. The prevalence of functional dyspepsia is significantly lower than the prevalence of uninvestigated dyspepsia and fluctuates around 10%. The risk factors for dyspepsia are usually tobacco smoking, non-steroidal anti-inflammatory drugs and/or aspirin, and Helicobacter pylori infection. The concept of the pathogenesis of functional dyspepsia undergoes significant changes. By analogy with the pathophysiology of irritable bowel syndrome, lesions of the relationship between the modulation of the cerebral cortex and the signal system of the gastroduodenal zone, the association of sluggish immune inflammation in the duodenum with motility and sensory activity of the stomach are most actively studied. The treatment of functional dyspepsia is a complex problem and changes after new ideas about its pathogenesis. Modern meta-analyzes have made it possible to expand the indications for the proton pump inhibitors administration, which can be actively used not only for the treatment of epigastric pain syndrome, but also for postprandial distress syndrome. Along with the required Helicobacter pylori eradication, there are reasons for the use of probiotics and antibiotics for the dyspepsia treatment.