bluuebunny/crossref_metadata_2025_split huggingface dataset:
Everyone Loves File
Authors: Kuszmaul Bradley C. , Frigo Matteo , Paluska Justin Mazzola , Sandler Alexander (Sasha) 
Published: March 2020

Oracle File Storage Service (FSS) is an elastic filesystem provided as a managed NFS service. A pipelined Paxos implementation underpins a scalable block store that provides linearizable multipage limited-size transactions. Above the block store, a scalable B-tree holds filesystem metadata and provides linearizable multikey limited-size transactions. Self-validating B-tree nodes and housekeeping operations performed as separate transactions allow each key in a B-tree transaction to require only one page in the underlying block transaction. The filesystem provides snapshots by using versioned key-value pairs. The system is programmed using a nonblocking lock-free programming style. Presentation servers maintain no persistent local state making them scalable and easy to failover. A non-scalable Paxos-replicated hash table holds configuration information required to bootstrap the system. An additional B-tree provides conversational multi-key minitransactions for control-plane information. The system throughput can be predicted by comparing an estimate of the network bandwidth needed for replication to the network bandwidth provided by the hardware. Latency on an unloaded system is about 4 times higher than a Linux NFS server backed by NVMe, reflecting the cost of replication. FSS has been in production since January 2018 and holds tens of thousands of customer file systems comprising many petabytes of data.
Effects of resveratrol or estradiol on postexercise endothelial function in estrogen-deficient postmenopausal women
Authors: Ozemek Cemal , Hildreth Kerry L. , Blatchford Patrick J. , Hurt K. Joseph , Bok Rachael , Seals Douglas R. , Kohrt Wendy M. , Moreau Kerrie L. 
Published: March 2020

Regular exercise enhances endothelial function in older men, but not consistently in estrogen-deficient postmenopausal women. Estradiol treatment improves basal endothelial function and restores improvements in endothelial function (flow-mediated dilation, FMD) to aerobic exercise training in postmenopausal women; however, estradiol treatment is controversial. Resveratrol, an estrogen receptor ligand, enhances exercise training effects on cardiovascular function and nitric oxide (NO) release in animal models, but impairs exercise training effects in men. We conducted a randomized cross-over, double-blinded, placebo-controlled pilot study to determine whether acute (single dose) resveratrol (250-mg tablet) or estradiol (0.05 mg/day transdermal patch) treatment enhances FMD at rest and after a single bout of moderate-intensity aerobic exercise in healthy estrogen-deficient postmenopausal women ( n = 15, 58.1 ± 3.2 yr). FMD was measured before and after (30, 60, and 120 min) a 40-min bout of moderate-intensity treadmill exercise (60–75% peak heart rate) under the respective conditions (separated by 1-2 wk). FMD was higher ( P < 0.05) before exercise and at all post-exercise time points in the resveratrol and estradiol conditions compared to placebo. FMD was increased from baseline by 120 min postexercise in the estradiol condition ( P < 0.001), but not resveratrol or PL conditions. Consistent with our previous findings, estradiol also enhances endothelial function in response to acute endurance exercise. Although resveratrol improved basal FMD, there was no apparent enhancement of FMD to acute exercise and, therefore, may not act as an estradiol mimetic. NEW & NOTEWORTHY The benefits of endurance exercise training on endothelial function are diminished in estrogen-deficient postmenopausal women, but estradiol treatment appears to restore improvements in endothelial function in this group. We show that basal endothelial function is enhanced with both acute estradiol and resveratrol treatments in estrogen-deficient postmenopausal women, but endothelial function is only enhanced following acute endurance exercise with estradiol treatment.
Effect of a single bout of exercise on clock gene expression in human leukocyte
Authors: Tanaka Yoshiaki , Ogata Hitomi , Kayaba Momoko , Ando Akira , Park Insung , Yajima Katsuhiko , Araki Akihiro , Suzuki Chihiro , Osumi Haruka , Zhang Simeng , Ishihara Asuka , Takahashi Keigo , Shoda Junichi , Nabekura Yoshiharu , Satoh Makoto , Tokuyama Kumpei 
Published: March 2020

Mammals have circadian clocks, which consist of the central clock in the suprachiasmatic nucleus and the peripheral clocks in the peripheral tissues. The effect of exercise on phase of peripheral clocks have been reported in rodents but not in humans. Continuous sampling is necessary to assess the phase of the circadian rhythm of peripheral clock gene expressions. It has been assumed that the expression of the genes in leukocyte may be “an accessible window to the multiorgan transcriptome.” The present study aimed to examine whether exercise affects the level and phase of clock gene expression in human leukocytes. Eleven young men participated in three trials, in which they performed a single bout of exercise at 60% V̇o2max for 1 h beginning either at 0700 (morning exercise) or 1600 (afternoon exercise) or no exercise (control). Blood samples were collected at 0600, 0900, 1200, 1500, 1800, 2100, and 2300 and at 0600 the next morning, to assess diurnal changes of clock gene expression in leukocytes. Brain and muscle ARNT-like protein 1 ( Bmal1) expression level increased after morning and afternoon exercise, and Cryptochrome 1 ( Cry1) expression level increased after morning exercise. Compared with control trial, acrophase of Bmal1 expression tended to be earlier in morning exercise trial and later in afternoon exercise trial. Acrophase of Cry1 expression was earlier in morning exercise trial but not affected by afternoon exercise. Circadian locomotor output cycles kaput ( Clock), Period 1–3 ( Per1–3), and Cry2 expression levels and those acrophases were not affected by exercise. The present results suggest a potential role of a single bout of exercise to modify peripheral clocks in humans. NEW & NOTEWORTHY The present study showed that a single bout of exercise affected peripheral clock gene expression in human leukocytes and the effect of exercise depended on when it was performed. Brain and muscle ARNT-like protein 1 ( Bmal1) expression was increased after exercises performed in the morning and afternoon. Cryptochrome 1 ( Cry1) expression was also increased after the morning exercise. The effect of exercise on acrophase of Bmal1 depended on the time of the exercise: advanced after morning exercise and delayed after afternoon exercise.
Computationally Derived Image Signature of Stromal Morphology Is Prognostic of Prostate Cancer Recurrence Following Prostatectomy in African American Patients
Authors: Bhargava Hersh K. , Leo Patrick , Elliott Robin , Janowczyk Andrew , Whitney Jon , Gupta Sanjay , Fu Pingfu , Yamoah Kosj , Khani Francesca , Robinson Brian D. , Rebbeck Timothy R. , Feldman Michael , Lal Priti , Madabhushi Anant 
Published: March 2020

Abstract

Purpose:
Between 30%–40% of patients with prostate cancer experience disease recurrence following radical prostatectomy. Existing clinical models for recurrence risk prediction do not account for population-based variation in the tumor phenotype, despite recent evidence suggesting the presence of a unique, more aggressive prostate cancer phenotype in African American (AA) patients. We investigated the capacity of digitally measured, population-specific phenotypes of the intratumoral stroma to create improved models for prediction of recurrence following radical prostatectomy.

Experimental Design:
This study included 334 radical prostatectomy patients subdivided into training (VT, n = 127), validation 1 (V1, n = 62), and validation 2 (V2, n = 145). Hematoxylin and eosin–stained slides from resected prostates were digitized, and 242 quantitative descriptors of the intratumoral stroma were calculated using a computational algorithm. Machine learning and elastic net Cox regression models were constructed using VT to predict biochemical recurrence-free survival based on these features. Performance of these models was assessed using V1 and V2, both overall and in population-specific cohorts.

Results:
An AA-specific, automated stromal signature, AAstro, was prognostic of recurrence risk in both independent validation datasets [V1,AA: AUC = 0.87, HR = 4.71 (95% confidence interval (CI), 1.65–13.4), P = 0.003; V2,AA: AUC = 0.77, HR = 5.7 (95% CI, 1.48–21.90), P = 0.01]. AAstro outperformed clinical standard Kattan and CAPRA-S nomograms, and the underlying stromal descriptors were strongly associated with IHC measurements of specific tumor biomarker expression levels.

Conclusions:
Our results suggest that considering population-specific information and stromal morphology has the potential to substantially improve accuracy of prognosis and risk stratification in AA patients with prostate cancer.
“Liquid Gold” - The unTAPped Potential of Cerebrospinal Fluid Analysis?
Authors: Glitza Oliva Isabella C. , Tawbi Hussein A. 
Published: March 2020

Abstract
Obtaining blood and cerebrospinal fluid is generally less invasive than standard tumor biopsy, and are increasingly used to develop surrogate biomarkers. Leptomeningeal disease, a devastating complication of cancer, represents a unique opportunity for using liquid biopsies for diagnosis, treatment, and to elucidate underlying mechanisms of resistance to therapy.
See related article by Smalley et al., p. 2163
Strasbourg Medical Expulsion Rulings: Beyond the Deathbed Requirement
Authors: den Exter André 
Published: March 2020

Abstract
For decades, the European Court of Human Rights (ECtHR) has applied a restrictive interpretation on the Article 3 threshold in extradition cases. The removal of aliens from the contracting state is lawful unless the applicant faces an imminent risk of death (D v. the United Kingdom (St Kitts)). However, with the Paposhvili ruling the Court has lowered the deathbed requirement to a more favourable standard as confirmed in the latest Savran case. But will those facing medical expulsion really benefit from this new standard at national level?
The Development of the Basil Valentine Corpus and Biography: Pseudepigraphic Corpora and Paracelsian Ideas
Authors: Principe Lawrence M. 
Published: March 2020

Abstract
Early modern alchemical literature is full of pseudonymous corpora. One of the most famous of these is connected with the name Basil Valentine, a supposed Benedictine monk and master of both medicinal and transmutational chymistry. Accreted over a period of nearly a century, the Valentine corpus is complex and heterogeneous. This paper endeavors to organize and recount the construction of the corpus by an array of authors, editors, publishers, and bibliographers, to sort out some of its strata, and to trace the origins and modifications of some of its texts. This exercise will be useful not only for further investigations of Basil Valentine and other pseudonymous chymical corpora, but also for broader studies of forgery and book history.
Development and Psychometric Testing of the Peer-Mentor Support Scale for Parents of Children With Type 1 Diabetes and for Youths With Type 1 Diabetes
Authors: Sullivan-Bolyai Susan , Bova Carol , Johnson Kimberly 
Published: March 2020

Purpose The purpose of this study was to develop and evaluate the psychometric properties of the Peer-Mentor Support Scale (PMSS), a measure of peer-mentor support provided to parents of children with type 1 diabetes (T1D) and to youths with T1D. Methods A multistage process was undertaken to include the following: item construction based on qualitive data from those who have experienced peer-mentor support, cognitive interviewing with parents and youths, content validity assessment, pilot testing of the scale, and psychometric evaluation of the PMSS with 165 participants. Results The final version of the PMSS included 17 items, scored on a 4-point Likert scale, with higher scores corresponding with greater peer-mentor support. The Cronbach’s alpha was .85 (n = 165), and the intraclass correlation coefficient was .78 (n = 38). No significant relationship was found between the PMSS score and general social support, suggesting that peer-mentor support is distinct from general social support. Principal components factor analysis with varimax rotation was performed, indicating that the scale was unidimensional and explained 59.3% of the variance in peer-mentor support. Conclusion The PMSS is a reliable and valid 17-item instrument that can be used to measure the unique contributions of peer mentorship for parents of children with T1DM and for youths with T1DM.
Application of Bone Marrow–Derived Mesenchymal Stem Cells for Muscle Healing After Contusion Injury in Mice
Authors: Chiu Chih-Hao , Chang Tsan-Hsuan , Chang Shih-Sheng , Chang Gwo-Jyh , Chen Alvin Chao-Yu , Cheng Chun-Ying , Chen Su-Ching , Fu Jen-Fen , Wen Chih-Jen , Chan Yi-Sheng 
Published: March 2020

Background: Skeletal muscle injuries are very common in sports medicine. Conventional therapies have limited clinical efficacy. New treatment methods should be developed to allow athletes to return to play with better function. Purpose: To evaluate the in vitro differentiation potential of bone marrow–derived mesenchymal stem cells and the in vivo histologic and physiologic effects of mesenchymal stem cell therapy on muscle healing after contusion injury. Study Design: Controlled laboratory study. Methods: Bone marrow cells were flushed from both femurs of 5-week-old C57BL/6 mice to establish immortalized mesenchymal stem cell lines. A total of 36 mice aged 8 to 10 weeks were used to develop a muscle contusion model and were divided into 6 groups (6 mice/group) on the basis of the different dosages of IM2 cells to be injected (0, 1.25 × 105, and 2.5 × 105 cells with/without F-127 in 100 μL of phosphate-buffered saline). Histological analysis of muscle regeneration was performed, and the fast-twitch and tetanus strength of the muscle contractions was measured 28 days after muscle contusion injury, after injections of different doses of mesenchymal stem cells with or without the F-127 scaffold beginning 14 days after contusion injury. Results: The mesenchymal stem cell–treated muscles exhibited numerous regenerating myofibers. All the groups treated with mesenchymal stem cells (1.25 × 105 cells, 2.5 × 105 cells, 1.25 × 105 cells plus F-127, and 2.5 × 105 cells plus F-127) exhibited a significantly higher number of regenerating myofibers (mean ± SD: 111.6 ± 14.77, 133.4 ± 21.44, 221.89 ± 32.65, and 241.5 ± 25.95, respectively) as compared with the control group and the control with F-127 (69 ± 18.79 and 63.2 ± 18.98). The physiologic evaluation of fast-twitch and tetanus strength did not reveal differences between the age-matched uninjured group and the groups treated with various doses of mesenchymal stem cells 28 days after contusion. Significant differences were found between the control group and the groups treated with various doses of mesenchymal stem cells after muscle contusion. Conclusion: Mesenchymal stem cell therapy increased the number of regenerating myofibers and improved fast-twitch and tetanus muscle strength in a mouse model of muscle contusion. However, the rapid decay of transplanted mesenchymal stem cells suggests a paracrine effect of this action. Treatment with mesenchymal stem cells at various doses combined with the F-127 scaffold is a potential therapy for a muscle contusion. Clinical Relevance: Mesenchymal stem cell therapy has an effect on sports medicine because of its effects on myofiber regeneration and muscle strength after contusion injury.
Prevalence of Frequent Mental Distress Among Illinois Adults With Chronic Conditions: Estimates From the Behavioral Risk Factor Surveillance System, 2011 to 2017
Authors: Price Janae D. , Amerson Nancy L. , Barbour Kamil E. , Emuze Damilola V. 
Published: March 2020

Purpose: The objective of this study was to examine frequent mental distress (FMD) by demographics, chronic conditions, and health risk factors among Illinois adults. Design: Descriptive analyses included χ2 and pairwise t tests to examine how FMD status differed by selected characteristics and Cox proportional hazards regression analysis to examine the association between FMD and chronic conditions and risk factors. Setting: Illinois Behavioral Risk Factor Surveillance System, 2011 to 2017 (n = 37 312). Participants: Adults who self-report FMD (n = 3455) were included. Measures: Prevalence of high blood pressure, coronary heart disease, chronic obstructive pulmonary disease, arthritis, asthma, high blood cholesterol, cancer, kidney disease, stroke, diabetes, weight status, physical activity status, smoking status, and drinking status. Results: A significantly higher FMD prevalence was found among females (11.7%; 95% confidence interval [CI]: 11.1-12.4), non-Hispanic blacks (13.4, 95% CI: 11.9-15.0), adults with less than a high school degree (14.4%; 95% CI: 12.6-16.3), adults with an annual income of less than $15 000 (21.4%; 95% CI: 19.4-23.5), and adults with a disability (23.3%, 95% CI: 21.9-24.7). Adjusted prevalence of FMD was significantly higher among adults for 8 of 10 chronic conditions and 4 of 5 health risk factors studied. Conclusions: Social stigmas related to depression and anxiety may lead to the underreporting of FMD. Chronic disease management programs in Illinois should consider integrating mental health services.
Centrally inserted tunnelled peripherally inserted central catheter: Off-label use for venous access in oncology patients
Authors: Lingegowda Dayananda , Gehani Anisha , Sen Saugata , Mukhopadhyay Sumit , Ghosh Priya 
Published: March 2020

Purpose: Vascular access in oncology patients can often be challenging, especially after a few cycles of chemotherapy through peripheral lines which can cause veins to become attenuated. We evaluated the feasibility of centrally placed non-cuffed tunnelled peripherally inserted central catheter in the chest as an alternative to conventional peripherally inserted central catheter. Method: Patients referred for peripherally inserted central catheter found to have inadequate peripheral venous access in their arms due to prior chemotherapy, and therefore they were offered placement of the non-cuffed tunnelled peripherally inserted central catheter in the chest. Adult patients were subjected to the procedure under local anaesthesia, while paediatric patients underwent this procedure under general anaesthesia. Ultrasound guidance was used for venous access, and fluoroscopy was used for tip positioning. Using internal jugular vein access, BARD Groshong-valved 4F peripherally inserted central catheter was placed with its tip in the cavo-atrial junction. Proximal end of the catheter was brought out through the subcutaneous tunnel, so that the exit point of the peripherally inserted central catheter lies over the upper chest. Extra length of the catheter was trimmed, and extensions were attached. The device was stabilized with adhesive and sutures. Results: Out of 19 patients, 18 patients were male (4–72 years). Technical success was achieved in 100% cases. No catheter-related bloodstream infection was noted within 30 days of peripherally inserted central catheter. Overall, during 1966 catheter days, no catheter-related bloodstream infection was observed. The purpose of peripherally inserted central catheter was achieved in 15 patients (78.9%) either in the form of completion of chemotherapy (8/15) or maintained peripherally inserted central catheter line till death (7/15). Partial or complete pullout was observed in four patients (20.1%), which required cuffed tunnelled catheter or implantable port. External fracture was noted in one patient, which was successfully corrected using repair kit. No exit site infection, bleeding, catheter occlusion, catheter dysfunction, venous thrombosis, venous stenosis or catheter embolizations were noted in our series. Conclusion: Centrally placed tunnelled peripherally inserted central catheter is a promising alternative method, when conventional arm peripherally inserted central catheter placement is not feasible. It is an easy and safe procedure that can be performed under local anaesthesia.
Language abilities in bilingual children: The effect of family background and language exposure on the development of Turkish and Dutch
Authors: Altinkamis Feyza , Simon Ellen 
Published: March 2020

Aims and objectives: The study investigates the effects of family background and language exposure on the language abilities of Turkish-Dutch bilingual children in their heritage language, Turkish, as well as in the majority language, Dutch. Methodology: Thirty-five children (3;01-6;11) participated in the study. All children took two standardized proficiency tests: CELF-Preschool 2 in Dutch and TEDİL in Turkish. Parents were interviewed on the family background and on the children’s use of and exposure to Dutch and Turkish. Data and analysis: Children’s test scores in Dutch and Turkish were analyzed in relation to the amount of exposure to Dutch and Turkish and the socio-economic and linguistic background of the parents. Findings: The results reveal that the children’s home context—both the linguistic background of the parents and the socio-educational level of the mother—affected the children’s scores, especially for Dutch. The amount of exposure to and use of Dutch and Turkish was correlated to the Dutch and Turkish scores. A qualitative discussion of children’s profiles revealed that children’s performance can only be fully understood when details of the home context, obtained through interviews with the parents, are taken into account. Originality: To date, few studies on bilingual children from families with a migration background have examined young children’s general language abilities in both the heritage language and the majority language. Implications: The study raises awareness of the importance of evaluating bilingual children’s language proficiencies in both languages, considering the effects of family background and language exposure on children’s bilingual language development. Limitations: The children’s language abilities were mapped on the basis of widely recognized standardized tests originally developed for the assessment of monolingual children. As more bilingual instruments are being tested and developed, future research will benefit from these tools.