bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute stroke awareness of family physicians: translation of policy to practice
Authors: Harsanyi Szilvia , Balogh Nandor , Kolozsvari Laszlo Robert , Mezes Laszlo , Papp Csaba , Zsuga Judit 
Published: October 2020

Abstract

Background
Translating clinical guidelines into routine clinical practice is mandatory to achieve population level improvement of health. Emergence of specific therapy for acute stroke yielded the ‘time is brain’ concept introducing the need for emergency treatment, pointing to the need for increasing stroke awareness of the general population. General practitioners (GPs) manage chronic diseases and could hence catalyse stroke awareness. In our study, the knowledge of general practitioners toward accurate identification of acute stroke candidacy was investigated.

Methods
GPs and residents in training for family medicine participated in a survey on a voluntary basis using supervised self-administration between the 1st of February 2018 and 31st July 2018. Two clinical cases of acute stroke that differed only regarding the patient’s eligibility for intravenous thrombolysis were presented. Participants answered two open-ended questions. Text analysis was performed using NVIVO software.

Results
Of the 127 respondents, 69 (54.3%) were female. The median age was 49 (34–62) years. The median time spent working after graduation was 14.5 (2–22.5) years. Board-certified GPs made up 77.2% of the sample. Qualitative analysis revealed stroke as the most frequent diagnosis for both cases. Territorial localization and possible aetiology were also established. Respondents properly identified eligibility for thrombolysis. Quantitative assessment showed that having the practice closer to the stroke centre increases the likelihood of adequate diagnosis for acute stroke.

Conclusions
Our results show that GPs properly diagnose acute stroke and identify intravenous thrombolysis candidates. Moreover, we found that a vigorous acute stroke triage system facilitates the translation of theory into practice.
Noncoding RNAs implication in cardiovascular diseases in the COVID-19 era
Authors: Greco S. , Madè A. , Gaetano C. , Devaux Y. , Emanueli C. , Martelli F. 
Published: October 2020

Abstract
COronaVIrus Disease 19 (COVID-19) is caused by the infection of the Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2). Although the main clinical manifestations of COVID-19 are respiratory, many patients also display acute myocardial injury and chronic damage to the cardiovascular system. Understanding both direct and indirect damage caused to the heart and the vascular system by SARS-CoV-2 infection is necessary to identify optimal clinical care strategies. The homeostasis of the cardiovascular system requires a tight regulation of the gene expression, which is controlled by multiple types of RNA molecules, including RNA encoding proteins (messenger RNAs) (mRNAs) and those lacking protein-coding potential, the noncoding-RNAs. In the last few years, dysregulation of noncoding-RNAs has emerged as a crucial component in the pathophysiology of virtually all cardiovascular diseases. Here we will discuss the potential role of noncoding RNAs in COVID-19 disease mechanisms and their possible use as biomarkers of clinical use.
Association of hypertension and hypertriglyceridemia on incident hyperuricemia: an 8-year prospective cohort study
Authors: Zhang Yuan , Zhang Miaomiao , Yu Xiawen , Wei Fengjiang , Chen Chen , Zhang Kai , Feng Shuzhi , Wang Yaogang , Li Wei-Dong 
Published: October 2020

Abstract

Background
Hypertension and high triglyceride are two of the most important risk factors for hyperuricemia. Epidemiological records show that hypertension and dyslipidemia often coexist and may significantly increase the risk of target organ damage. However, their combined effect on incident hyperuricemia is poorly understood. Thus, we aimed to investigate the separate and combined effect of hypertension and hypertriglyceridemia on the incidence of hyperuricemia.

Methods
A prospective cohort study of 6424 hyperuricemia-free participants aged 20 to 94 years between August 2009 and October 2017 was performed at Tianjin General Hospital of China. Participants were categorized into four groups by combining hypertension and hypertriglyceridemia status at baseline. The restricted cubic spline fitting Cox regression model was used to evaluate the relationship between blood pressure and triglyceride and hyperuricemia. Cox regression models were performed to calculate hazard ratios (HRs) and 95% confident intervals (CIs) to estimate baseline factors and their association with the incidence of hyperuricemia. A Kaplan–Meier survival analysis was performed to compare the incidence of hyperuricemia among subjects in each separate and combined hypertension and hypertriglyceridemia group.

Results
During the 8-year follow-up period, 1259 subjects developed hyperuricemia (20.6%). There existed positive relationships between blood pressure and triglyceride levels and hyperuricemia. This risk factor arising from a combination of the two (HR, 3.02; 95% CI 2.60–3.50) is greater than that from hypertension (HR, 1.48; 95% CI 1.28–1.71) or hypertriglyceridemia (HR, 1.84; 95% CI 1.55–2.18) separately. The Kaplan–Meier survival analysis indicated that combined effect of hypertension and hypertriglyceridemia may predict higher onset of hyperuricemia.

Conclusion
The combined effect of hypertension and hypertriglyceridemia on the risk of hyperuricemia is much stronger than that by hypertension or hypertriglyceridemia separately. Hypertension combined with hypertriglyceridemia may be an independent and powerful predictor for hyperuricemia.
Telemedicine in pediatric rheumatology: this is the time for the community to embrace a new way of clinical practice
Authors: Shenoi Susan , Hayward Kristen , Curran Megan L. , Kessler Elizabeth , Mehta Jay J. , Riebschleger Meredith P. , Foster Helen E. 
Published: October 2020

Abstract

Background
The use of telemedicine in pediatric rheumatology has been historically low. The current COVID 19 global pandemic has forced a paradigm shift with many centers rapidly adopting virtual visits to conduct care resulting in rapid expansion of use of telemedicine amongst practices.

Body
This commentary discusses practical tips for physicians including guidance around administrative and governance issues, preparation for telemedicine, involving the multidisciplinary care team, and teaching considerations. We also outline a standard proforma and smart phrases for the electronic health record. A proposed variation of the validated pediatric gait arms legs spine examination (pGALS) called the video pGALS (VpGALS) as a means of conducting virtual pediatric rheumatology physical examination is presented.

Conclusion
This commentary provides a starting framework for telemedicine use in pediatric rheumatology and further work on validation and acceptability is needed.
Identification key to the Anopheles mosquitoes of South America (Diptera: Culicidae). III. Male genitalia
Authors: Sallum Maria Anice Mureb , Obando Ranulfo González , Carrejo Nancy , Wilkerson Richard C. 
Published: October 2020

Abstract
Background
Accurate identification of the species of Anopheles Meigen, 1818 requires careful examination of all life stages. However, morphological characters, especially those of the females and fourth-instar larvae, show some degree of polymorphism and overlap among members of species complexes, and sometimes even within progenies. Characters of the male genitalia are structural and allow accurate identification of the majority of species, excluding only those in the Albitarsis Complex. In this key, based on the morphology of the male genitalia, traditionally used important characters are exploited together with additional characters that allow robust identification of male Anopheles mosquitoes in South America.

Methods
Morphological characters of the male genitalia of South American species of the genus Anopheles were examined and employed to construct a comprehensive, illustrated identification key. For those species for which specimens were not available, illustrations were based on published illustrations. Photographs of key characters of the genitalia were obtained using a digital Canon Eos T3i attached to a light Diaplan Leitz microscope. The program Helicon Focus was used to build single in-focus images by stacking multiple images of the same structure.

Results
An illustrated key to South American species of Anopheles based on the morphology of the male genitalia is presented, together with a glossary of morphological terms. The male genitalia of type-specimens of previously poorly documented species were also examined and included in the key, e.g. Anopheles (Anopheles) tibiamaculatus (Neiva, 1906) which has a unique quadrangular-shaped aedeagus with an apical opening.

Conclusions
Male genitalia of South American species of Anopheles possess robust characters that can be exploited for accurate species identification. Distortion that can occur during the dissection and mounting process can obstruct accurate identification; this is most evident with inadvertent damage or destruction of unique features and interferes with correctly assigning shapes of the features of the ventral claspette. In some species, the shape, and anatomical details of the aedeagus also need to be examined for species identification. For members of the Myzorhynchella Series, both ventral and dorsal claspettes possess multiple characteristics that are herein used as reliable characters for species identification.
Effect of APOE ε4 genotype on amyloid-β and tau accumulation in Alzheimer’s disease
Authors: Baek Min Seok , Cho Hanna , Lee Hye Sun , Lee Jae Hoon , Ryu Young Hoon , Lyoo Chul Hyoung 
Published: October 2020

AbstractBackgroundTo assess the effects of apolipoprotein E (ApoE) ε4 genotype on amyloid-β (Aβ) and tau burden and their longitudinal changes in Alzheimer’s disease (AD) spectrum.MethodsAmong 272 individuals who underwent PET scans (18F-florbetaben for Aβ and18F-flortaucipir for tau) and ApoE genotyping, 187 individuals completed 2-year follow-up PET scans. After correcting for the partial volume effect, we compared the standardized uptake value ratio (SUVR) for Aβ and tau burden between the ε4+ and ε4− groups. By using a linear mixed-effect model, we measured changes in SUVR in the ApoE ε4+ and ε4− groups.ResultsThe ε4+ group showed greater baseline Aβ burden in the diffuse cortical regions and greater tau burden in the lateral, and medial temporal, cingulate, and insula cortices. Tau accumulation rate was higher in the parietal, occipital, lateral, and medial temporal cortices in the ε4+ group. In Aβ+ individuals, baseline tau burden was greater in the medial temporal cortex, while Aβ burden was conversely greater in the ε4− group. Tau accumulation rate was higher in the ε4+ group in a small region in the lateral temporal cortex. The effect of ApoE ε4 on enhanced tau accumulation persisted even after adjusting for the global cortical Aβ burden.ConclusionsProgressive tau accumulation may be more prominent in ε4 carriers, particularly in the medial and lateral temporal cortices. ApoE ε4 allele has differential effects on the Aβ burden depending on the existing amyloidosis and may enhance vulnerability to progressive tau accumulation in the AD spectrum independent of Aβ.
Complete migration of a composite mesh into small bowel incidentally found during laparotomy for colectomy in an asymptomatic patient: a case report
Authors: Chandrasinghe Pramodh , De Silva Asantha , Welivita Ayomi , Deen Kemal 
Published: October 2020

Abstract

Background
Composite meshes are used for incisional hernia repair because they enable intraperitoneal mesh placement due to their dorsal surface, which is made of inert material. We report, for the first time, to our knowledge, a case of composite mesh migration detected incidentally during a laparotomy for colon cancer in an asymptomatic patient.

Case presentation
Our patient was a 71-year-old South Asian man who underwent ventral mesh repair following a postoperative complication after right hemicolectomy for colon cancer. The patient was diagnosed with a metachronous sigmoid cancer 5 years later, for which he underwent laparotomy. During laparotomy, a migrated mesh was incidentally found and extracted from his proximal ileum without any evidence of abscess or fistula formation.

Conclusion
To our knowledge, this is the first report of an incidentally found migrated composite mesh from a bowel lumen in an asymptomatic patient.
Parametric model construction of solid mechanics based on wireless environment and cloud computing mode
Authors: Jian Longji , Song Feifei , Huang Yuansong 
Published: October 2020

Abstract
Traditional parametric models of solid mechanics have disadvantages such as poor lightweight level of cloud data and low integrity of operations of solid mechanics. To solve the above problems, a parametric model for solid mechanics in engineering research based on cloud computing models is designed. By calculating the number of cloud data copy optimizations, the upper limit of resources required for engineering research is estimated, and the specific values is assessed by continuously cycling the demand, so as to complete the basic conflict analysis, and set up a cloud computing engineering research environment. On this basis, the modeling index is selected. By analyzing the sensitivity of the index, the purpose of optimizing the modeling parameters is achieved, and a new solid mechanics parametric model is constructed. Analyzing and contrasting the experimental data shows that after applying the parametric model of solid mechanics in the engineering research based on the cloud computing model, the lightweight level of cloud data can be increased by up to 24 levels, and the operational integrity of solid mechanics can be increased by about 30%.
On the reproduction number and the optimal control of infectious diseases in a heterogenous population
Authors: Chukwu A. U. , Akinyemi J. A. , Adeniyi M. O. , Salawu S. O. 
Published: October 2020

Abstract
The effect of infectious diseases cannot be overemphasised. The continuing surfacing of the infectious diseases gives the stakeholders a great concern. In this paper, the nature of the spread of Ebola virus outbreak in West Africa in 2014 is studied. We develop a model that analyses the spread of infectious diseases, and the reproduction number is determined by using the next generation matrix method. Finally, the effects of treatment of the infected individuals and vaccination of the susceptible population as the control strategies are looked into. The optimal control system showed that the combination of the two strategies proved more effective.
Optical solitons of fractional complex Ginzburg–Landau equation with conformable, beta, and M-truncated derivatives: a comparative study
Authors: Hussain Amjad , Jhangeer Adil , Abbas Naseem , Khan Ilyas , Sherif El-Syed M. 
Published: October 2020

Abstract
In this paper, we investigate the optical solitons of the fractional complex Ginzburg–Landau equation (CGLE) with Kerr law nonlinearity which shows various phenomena in physics like nonlinear waves, second-order phase transition, superconductivity, superfluidity, liquid crystals, and strings in field theory. A comparative approach is practised between the three suggested definitions of derivative viz. conformable, beta, and M-truncated. We have constructed the optical solitons of the considered model with a new extended direct algebraic scheme. By utilization of this technique, obtained solutions carry a variety of new families including dark-bright, dark, dark-singular, and singular solutions of Type 1 and 2, and sufficient conditions for the existence of these structures are given. Further, graphical representations of the obtained solutions are depicted. A detailed comparison of solutions to the considered problem, obtained by using different definitions of derivatives, is reported as well.
A general quantum Laplace transform
Authors: Shehata Enas M. , Faried Nashat , El Zafarani Rasha M. 
Published: October 2020

Abstract
In this paper, we introduce a general quantum Laplace transform $\mathcal{L}_{\beta }$

L
β

and some of its properties associated with the general quantum difference operator ${D}_{\beta }f(t)= ({f(\beta (t))-f(t)} )/ ({ \beta (t)-t} )$

D
β

f
(
t
)
=
(
f
(
β
(
t
)
)
−
f
(
t
)
)
/
(
β
(
t
)
−
t
)
, β is a strictly increasing continuous function. In addition, we compute the β-Laplace transform of some fundamental functions. As application we solve some β-difference equations using the β-Laplace transform. Finally, we present the inverse β-Laplace transform $\mathcal{L}_{\beta }^{-1}$

L
β

−
1

.
Traveling waves in nonlocal dispersal SIR epidemic model with nonlinear incidence and distributed latent delay
Authors: Wu Weixin , Teng Zhidong 
Published: October 2020

Abstract
This paper studies the traveling waves in a nonlocal dispersal SIR epidemic model with nonlinear incidence and distributed latent delay. It is found that the traveling waves connecting the disease-free equilibrium with endemic equilibrium are determined by the basic reproduction number $\mathcal{R}_{0}$

R
0

and the minimal wave speed $c^{*}$

c
∗

. When $\mathcal{R}_{0}>1$

R
0

>
1
and $c>c^{*}$
c
>

c
∗

, the existence of traveling waves is established by using the upper-lower solutions, auxiliary system, constructing the solution map, and then the fixed point theorem, limiting argument, diagonal extraction method, and Lyapunov functions. When $\mathcal{R}_{0}>1$

R
0

>
1
and $0< c< c^{*}$
0
<
c
<

c
∗

, the nonexistence result is also obtained by using the reduction to absurdity and the theory of asymptotic spreading.
Tiotropium/Olodaterol treatment reduces cigarette smoke extract-induced cell death in BEAS-2B bronchial epithelial cells
Authors: Chen Cheng-hsiung , Li Yi-Rong , Lin Sheng-Hao , Chang Hsiu-Hui , Chai Woei-Horng , Chan Po-Chiang , Lin Ching-Hsiung 
Published: October 2020

Abstract

Background
Cigarette smoking is a critical risk factor for the destruction of lung parenchyma or the development of emphysema, which is characteristic of COPD. Disruption of epithelial layer integrity may contribute to lung injury following cigarette smoke extract (CSE) exposure. Tiotropium/olodaterol acts as a bronchodilator for COPD treatment; however, the effect of dual bronchodilators on epithelial cell injury and its underlying mechanism remain unclear. In this study, we evaluated the effect of tiotropium/olodaterol on CSE-mediated cell death and the underlying mechanisms.

Methods
Cell viability was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Apoptosis, necrosis, and autophagy were evaluated using flow cytometry. Autophagy-related protein, phosphorylated ERK, expression was determined using Western blotting.

Results
Tiotropium/olodaterol significantly inhibited CSE-induced cell death, mitochondria dysfunction, and autophagy, which had no significant effect on apoptosis or necrosis in BEAS-2B human bronchial epithelial cells. Moreover, tiotropium/olodaterol attenuated CSE-induced upregulation of JNK.

Conclusions
CSE induced cell death and caused consistent patterns of autophagy and JNK activation in BEAS-2B human bronchial epithelial cells. Tiotropium/olodaterol treatment protected bronchial epithelial cells from CSE-induced injury and inhibited activation of autophagy and upregulation of JNK phosphorylation. These results indicate that tiotropium/olodaterol may protect epithelial cells from the deleterious effects of CSE exposure, which is associated with the regulation of autophagy and JNK activation.
On the comparability of adults with low literacy across LEO, PIAAC, and NEPS. Methodological considerations and empirical evidence
Authors: Durda Tabea , Gauly Britta , Buddeberg Klaus , Lechner Clemens M. , Artelt Cordula 
Published: October 2020

AbstractBackgroundIn Germany, three large-scale surveys–the Level One Study (LEO), the Programme for the International Assessment of Adult Competencies (PIAAC), and the National Educational Panel Study (NEPS)–provide complementary data on adults’ literacy skills that can be harnessed to study adults with low literacy. To ensure that research on low-literate adults using these surveys arrives at valid and robust conclusions, it is imperative to ascertain the comparability of the three surveys’ low-literacy samples. Towards that end, in the present study, we comprehensively assess the comparability of adults with low literacy across these surveys with regard to their sociodemographic and socioeconomic characteristics.MethodsWe used data from LEO, PIAAC, and NEPS. We identified features of the sample representation and measurement of (low) literacy as potential causes for variations in the low-literacy samples across the surveys. We then compared the low-literacy samples with regard to their sociodemographic and socioeconomic characteristics and performed logistic regressions to compare the relative importance of these characteristics as correlates of low literacy.ResultsThe key insight our study provides is that–despite different sample representations and measurement approaches–the low-literacy samples in the three surveys are largely comparable in terms of their socioeconomic and sociodemographic characteristics. Although there were small differences between the surveys with regard to the distribution of gender, educational attainment, and the proportion of non-native speakers within the group of low-literate adults, results revealed that both the prevalence of low literacy and its correlates were largely robust across LEO, PIAAC, and NEPS. Across all three surveys, lower educational attainment emerged as the most significant correlate of low literacy, followed by a non-German language background, unemployment and low occupational status.ConclusionsOur study provides evidence that all three surveys can be used for investigating adults with low literacy. The small differences between the low-literacy samples across the three surveys appear to be associated with sample representation and certain assessment features that should be kept in mind when using the surveys for research and policy purposes. Nevertheless, our study showed that we do not compare apples with oranges when dealing with low-literate adults across different large-scale surveys.