bluuebunny/crossref_metadata_2025_split huggingface dataset:
The implied volatility smirk of commodity options
Authors: Jia Xiaolan , Ruan Xinfeng , Zhang Jin E. 
Published: October 2020

AbstractThis paper studies the implied volatility (IV) smirks in four commodity markets by adopting Zhang and Xiang's methodology. First, we document the term structure and dynamics of IV smirks. Overall, the commodity IV curves are negatively skewed with a positive curvature. Then we analyze the commodity and S&P 500 returns' predictability based on in‐sample and out‐of‐sample tests and find that the information embedded in IV smirks can significantly predict monthly commodity and S&P 500 returns. For example, the risk‐neutral fourth cumulant (FC) from the crude oil market outperforms all of the standard predictors in predicting the S&P 500 returns.
Cortical thickness as predictor of response to exercise in people with Parkinson's disease
Authors: Silva‐Batista Carla , Ragothaman Anjanibhargavi , Mancini Martina , Carlson‐Kuhta Patricia , Harker Graham , Jung Se Hee , Nutt John G. , Fair Damien A , Horak Fay B. , Miranda‐Domínguez Oscar 
Published: October 2020

AbstractWe previously showed that dual‐task cost (DTC) on gait speed in people with Parkinson's disease (PD) improved after 6 weeks of the Agility Boot Camp with Cognitive Challenge (ABC‐C) exercise program. Since deficits in dual‐task gait speed are associated with freezing of gait and gray matter atrophy, here we performed preplanned secondary analyses to answer two questions: (a) Do people with PD who are freezers present similar improvements compared to nonfreezers in DTC on gait speed with ABC‐C? (b) Can cortical thickness at baseline predict responsiveness to the ABC‐C? The DTC from 39 freezers and 43 nonfreezers who completed 6 weeks of ABC‐C were analyzed. A subset of 51 participants (21 freezers and 30 nonfreezers) with high quality imaging data were used to characterize relationships between baseline cortical thickness and delta (Δ) DTC on gait speed following ABC‐C. Freezers showed larger ΔDTC on gait speed than nonfreezers with ABC‐C program (p < .05). Cortical thickness in visual and fronto‐parietal areas predicted ΔDTC on gait speed in freezers, whereas sensorimotor‐lateral thickness predicted ΔDTC on gait speed in nonfreezers (p < .05). When matched for motor severity, visual cortical thickness was a common predictor of response to exercise in all individuals, presenting the largest effect size. In conclusion, freezers improved gait automaticity even more than nonfreezers from cognitively challenging exercise. DTC on gait speed improvement was associated with larger baseline cortical thickness from different brain areas, depending on freezing status, but visual cortex thickness showed the most robust relationship with exercise‐induced improvements in DTC.
Hillslope sediment production after wildfire and post‐fire forest management in northern California
Authors: Cole Ryan P. , Bladon Kevin D. , Wagenbrenner Joseph W. , Coe Drew B. R. 
Published: October 2020

AbstractHigh severity wildfires impact hillslope processes, including infiltration, runoff, erosion, and sediment delivery to streams. Wildfire effects on these processes can impair vegetation recovery, producing impacts on headwater and downstream water supplies. To promote forest regeneration and maintain forest and aquatic ecosystem functions, land managers often undertake active post‐fire land management (e.g., salvage logging, sub‐soiling, re‐vegetation). The primary objective of our study was to quantify and compare sediment yields eroded from (a) burned, (b) burned and salvage logged, and (c) burned, salvage logged, and sub‐soiled plots following the 2015 Valley Fire in the northern California Coast Range. We distributed 25 sediment fences (~75 m2 contributing area) across four hillslopes burned at high severity and representative of the three management types. We collected eroded sediment from the fences after precipitation events for 5 years. We also quantified precipitation, canopy cover, ground cover, and soil properties to characterize the processes driving erosion across the three management types. Interestingly, during the second year after the fire, sediment yields were greater in the burned‐only plots compared with both the salvage logged and sub‐soiled plots. By the third year, there were no differences in sediment yields among the three management types. Sediment yields decreased over the 5 years of the study, which may have occurred due to site recovery or exhaustion of mobile sediment. As expected, sediment yields were positively related to precipitation depth, bulk density, and exposed bare soil, and negatively related to the presence of wood cover on the soil surface. Unexpectedly, we observed greater sediment yields on the burned‐only plots with greater canopy closure, which we attributed to increased throughfall drop size and kinetic energy related to the residual canopy. While these results will aid post‐fire management decisions in areas with Mediterranean climates prone to low intensity, long duration rainstorms, additional research is needed on the comparative effects of post‐fire land management approaches to improve our understanding of the mechanisms driving post‐fire erosion and sediment delivery.
Three hundred years of snowpack variability in southwestern British Columbia reconstructed from tree‐rings
Authors: Mood Bryan J. , Coulthard Bethany , Smith Dan J. 
Published: October 2020

AbstractRecent snow droughts in southwestern British Columbia (BC), Canada, have reduced seasonal streamflow during the typically dry late‐spring and summer months, leading to socio‐economic and ecological impacts that draw attention to the impending consequences of climate change. Knowledge of annual winter snowfall variability within this region is largely derived from a sparse network of short‐duration (≤50 years) snow survey stations. In this paper, we develop an annual April 1 snow water equivalent (SWE) reconstruction from living tree‐ring chronologies that offer a perspective on long‐term natural snowpack variability. The dendrohydrological model estimates the first principal component April 1 SWE for the southwestern regions of BC to 1711. Spectral analysis identified dominant multidecadal April 1 SWE variability over the pre‐instrumental period. The reconstruction successfully captures known instrumental period influences of La Niña oscillations on reconstructed SWE, suggesting that our tree‐ring based the reconstruction has the potential to provide insights on pre‐instrumental ocean–atmosphere links with southwestern BC snowpack dynamics. Runs analysis suggests pre‐instrumental snow droughts have been more than twice as long in duration and severity than during the observed period which indicates the instrumental record may not capture the full range of April 1 SWE variability. The reconstruction provides the first high‐resolution description of SWE over the past 300 years in southwestern BC and is of immediate use to regional water resource managers.
Identification of novel ALK rearrangements in gynecologic clear cell carcinoma
Authors: Yang Chen , Zhang Lingxin , Love‐Gregory Latisha , Sun Lulu , Hagemann Ian S. , Cao Dengfeng 
Published: October 2020

AbstractClear cell carcinomas (CCCs) of the gynecologic tract are aggressive tumors with high resistance rate to conventional platinum‐based chemotherapies. Currently, the molecular features of these tumors remain largely unknown and there is no targeted therapy available. The aim of our study was to identify anaplastic lymphoma kinase (ALK) translocations, a potential molecular target for therapy. Ninety‐seven patients with gynecologic CCC (62 ovarian, 27 uterine corpus and 8 uterine cervical) were screened for ALK rearrangement and ALK copy number gain using an ALK break‐apart fluorescence in situ hybridization probe. The genomic landscape of all cases with ALK rearrangements and 10 random cases with ALK copy number gain was queried using a hybrid capture‐based DNA next‐generation sequencing assay and an Illumina Fusion RNA assay. Findings were then correlated with ALK immunohistochemistry (clone D5F3) expression. ALK rearrangement was detected in 5% (5/97) and ALK copy number gain in 79% (77/97) of gynecologic CCCs. Next‐generation sequencing in ALK‐rearranged CCCs identified a novel BABAM2‐ALK fusion in one case. ALK translocation partners were not identified in the remaining cases. Our findings show that ALK fusion, which is targetable in other cancers, may be a pathogenetic mechanism in a small number of gynecologic CCCs.
Influences of uncertainty on the returns and liquidity of cryptocurrencies: Evidence from a portfolio approach
Authors: Nguyen Quang Binh , Le Thai‐Ha , Nguyen Phuc Canh 
Published: October 2020

AbstractThis study examines the influences of different types of uncertainty, namely, World Uncertainty (WUI), Global Economic Policy Uncertainty (GEPU), and Geopolitical Uncertainty (GUI) on the returns and liquidity of 964 cryptocurrencies over the period from April 28, 2013 to July 14, 2018. Besides the full sample, three sub‐portfolios are separated by market capitalization. The principal findings are: (i) increased GEPU has significantly negative effect on the cryptocurrency portfolios' returns; (ii) higher WUI has significantly negative impact on the cryptocurrency portfolios' liquidity, especially for the medium sub‐portfolio; (iii) the effects of uncertainty proxied by GEPU and WUI on cryptocurrency portfolios' returns and liquidity, respectively, are asymmetric; and (iv) GUI is not found to have any significant impact on the returns and liquidity of cryptocurrency portfolios.
Does culture play a role in the stock market's response to uncertainty?
Authors: Xu Jingjing 
Published: October 2020

AbstractWhile a growing body of literature documents a decrease in stock returns with an increase in economic uncertainty, the magnitude of this decrease may differ across countries. This paper examines whether a national culture that shapes its people's views towards uncertainty can serve as an explanation if there are heterogeneous responses of the stock market responses to an increase in economic uncertainty at the country level. Using the economic policy uncertainty (EPU) index to proxy for economic uncertainty and employing an SVAR model, this paper first finds that the magnitude of a stock market's response to an increase in uncertainty varies across countries. This paper then adopts the uncertainty avoidance index (UAI) as a proxy measure of culture relating to people's views towards uncertainty and finds that the observed cross‐country heterogeneity is correlated with the degree of a society's uncertainty avoidance. The stock market index is likely to drop more in response to an increase in uncertainty in countries with higher uncertainty avoidance.
Rat bone healing induced by natural nanocrystalline carbonated hydroxyapatite in combination with human amniotic fluid stem cells (AFSCs)
Authors: Centurione Lucia , Pantalone Andrea , Marchegiani Francesco , Antonucci Ivana , Basile Mariangela , Salini Vincenzo , Stuppia Liborio , Di Pietro Roberta 
Published: October 2020

AbstractThe present study was aimed at identifying a new scaffold/stem cell combination useful to treat large bone defects. Human amniotic fluid stem cells (AFSCs) were expanded in vitro, labeled with a fluorescent cell‐permeable dye (PKH26) and transplanted in vivo in a femoral injured rat model. The femoral defect was left untreated (control rats) or filled with hydroxyapatite (HA; natural nanocrystalline carbonated hydroxyapatite‐Orthoss®) scaffold alone or loaded with PKH26‐labeled AFSCs. All animals were killed 3 weeks after implantation. Both gross anatomy and histological observations revealed a major bone regenerative response in rat specimens treated with HA scaffold, alone or supplemented with AFSCs. Samples injected with HA plus AFSCs displayed the presence of abundant fibrotic tissue, the formation of periosteal woven bone, and an increased presence of blood vessels in the bone marrow, with still fluorescent AFSCs in close proximity. These observations provide evidence that natural HA plus AFSCs represents a promising alternative therapeutic strategy to autologous bone grafting procedures.
Thymoquinone alleviates liver fibrosis via miR‐30a‐mediated epithelial‐mesenchymal transition
Authors: Geng Wujun , Li Chunxue , Zhan Yating , Zhang Rongrong , Zheng Jianjian 
Published: October 2020

AbstractThymoquinone (TQ), the main active constituent of Nigella sativa seeds, has been shown to play a role in antioxidation, anti‐inflammation, and antitumor. Recent studies have demonstrated that TQ contributes to the suppression of liver fibrosis. Abnormal activated epithelial‐mesenchymal transition (EMT) promotes the activation of hepatic stellate cells (HSCs). However, whether the antifibrotic effects of TQ occur through inhibiting EMT is largely unknown. In this study, it was found that TQ ameliorated liver fibrosis and collagen accumulation in carbon tetrachloride (CCl4) mice. In vitro, TQ inhibited HSC activation including reduced proliferation, α‐smooth muscle actin, and collagen. In addition, TQ markedly suppressed the EMT process, with enhanced E‐cadherin and reduced desmin. Notably, snail family transcriptional repressor 1 (Snai1), the EMT master transcription factor, was obviously inhibited by TQ in vivo and in vitro. Further studies demonstrated that Snai1 was a target of microRNA‐30a (miR‐30a), which was upregulated by TQ. Interestingly, the effects of TQ on HSC activation and EMT were almost inhibited by miR‐30a inhibitor. Collectively, we demonstrate that TQ inhibits HSC activation, at least in part, via regulation of miR‐30a and Snai1. TQ upregulates miR‐30a expression, resulting in a reduced Snai1 level as well as EMT process inactivation, which contributes to the inhibition of HSC activation. TQ may be a potential therapeutic agent for liver fibrosis.
IL‐1/IL‐1R signaling induced by all‐trans‐retinal contributes to complement alternative pathway activation in retinal pigment epithelium
Authors: Cheng Xinxuan , He Danxue , Liao Chunyan , Lin Sijie , Tang Liying , Wang Yuan‐Liang , Hu Jiaoyue , Li Wei , Liu Zuguo , Wu Yalin , Liao Yi 
Published: October 2020

AbstractThe underlying mechanisms of complement activation in Stargardt disease type 1 (STGD1) and age‐related macular degeneration (AMD) are not fully understood. Overaccumulation of all‐trans‐retinal (atRAL) has been proposed as the pathogenic factor in both diseases. By incubating retinal pigment epithelium (RPE) cells with atRAL, we showed that C5b‐9 membrane attack complexes (MACs) were generated mainly through complement alternative pathway. An increase in complement factor B (CFB) expression as well as downregulation of complement regulatory proteins CD46, CD55, CD59, and CFH were observed in RPE cells after atRAL treatment. Furthermore, interleukin‐1β production was provoked in both atRAL‐treated RPE cells and microglia/macrophages. Coincubation of RPE cells with interleukin‐1 receptor antagonist (IL1Ra) and atRAL ameliorated complement activation and downregulated CFB expression by attenuating both p38 and c‐Jun N‐terminal kinase (JNK) signaling pathways. Our findings demonstrate that atRAL induces an autocrine/paracrine IL‐1/IL‐1R signaling to promote complement alternative pathway activation in RPE cells and provide a novel perspective on the pathomechanism of macular degeneration.
The functional connectivity study on the brainstem‐cortical/subcortical structures in responders following cervical vagus nerve stimulation
Authors: Zhu Jin , Wang Jingjuan , Xu Cuiping , Zhang Xi , Qiao Liang , Wang Xueyuan , Zhang Xiaohua , Yan Xiaoming , Ni Duanyu , Yu Tao , Zhang Guojun , Li Yongjie 
Published: October 2020

AbstractBackgroundCervical vagus nerve stimulation (VNS) is an effective neuromodulation therapy for patients with drug‐resistant epilepsy (DRE). The previous studies reported that VNS may reduce seizures by regulating the functional connectivity (FC) between cortical and subcortical regions. However, no studies on brainstem have been done in responders who achieved ≥50% seizure reduction following VNS.MethodsEight healthy controls and eight patients who became responders after 3 months of operation were enrolled in this study. Resting‐state functional MRI (rs‐fMRI) was performed, and two sample and paired sample t test were, respectively, used to detect altered FC between brainstem and cortical/subcortical regions between controls and patients, between preoperative and postoperative patients.ResultsIn the control group, regions with highest FC to brainstem included bilateral anterior cingulate gyri, left basal ganglia, left insula, left cuneus, right precuneus, and bilateral cerebellum. In preoperative patients, right frontal middle gyrus, bilateral basal ganglia, and right cerebellum were showed highest FC to brainstem. Compared with the controls, preoperative patients exhibited increased FC in bilateral inferior frontal gyri, right temporal cortex, while decreased FC in left insula, left postcentral gyrus, right posterior cingulate gyrus, right precuneus, and left superior parietal gyrus. In postoperative patients, regions with increased FC to brainstem were left insula, left precuneus and left cuneus, and those with decreased FC were right inferior occipital gyrus and right cerebellum.ConclusionsRecurrent seizures caused disturbances in brainstem‐cortical/subcortical FC, especially in motor executive function related regions and default mode network. VNS could reorganize the altered FC between brainstem and insula, precuneus, and cerebellum in responders.
Synthesis and structural anomaly ofxyloketals‐uniquebenzoxacycles: A review
Authors: Roy Barnali , Rout Nilendri , Kuila Puspendu , Sarkar Debayan 
Published: October 2020

AbstractXyloketals, unique bioactive compounds, isolated from mangrove fungusXylariasp. (no. 2508), having multiple pharmacological, therapeutic properties, have prompted enormous research on their stereochemistry, bioactivity and synthetic attempts made toward this novel family. This review brings forward a systematic and comprehensive survey of the method of both racemic and enantioselective synthesis, reactivity, and biological properties associated with the xyloketal derivatives and their analogues.
Clinical presentation and long‐term follow‐up of dopamine beta hydroxylase deficiency
Authors: Wassenberg Tessa , Deinum Jaap , van Ittersum Frans J. , Kamsteeg Erik‐Jan , Pennings Maartje , Verbeek Marcel M. , Wevers Ron A. , van Albada Mirjam E. , Kema Ido P. , Versmissen Jorie , van den Meiracker Ton , Lenders Jacques W.M. , Monnens Leo , Willemsen Michèl A. 
Published: October 2020

AbstractDopamine beta hydroxylase (DBH) deficiency is an extremely rare autosomal recessive disorder with severe orthostatic hypotension, that can be treated with L‐threo‐3,4‐dihydroxyphenylserine (L‐DOPS). We aimed to summarize clinical, biochemical, and genetic data of all world‐wide reported patients with DBH‐deficiency, and to present detailed new data on long‐term follow‐up of a relatively large Dutch cohort. We retrospectively describe 10 patients from a Dutch cohort and 15 additional patients from the literature. We identified 25 patients (15 females) from 20 families. Ten patients were diagnosed in the Netherlands. Duration of follow‐up of Dutch patients ranged from 1 to 21 years (median 13 years). All patients had severe orthostatic hypotension. Severely decreased or absent (nor)epinephrine, and increased dopamine plasma concentrations were found in 24/25 patients. Impaired kidney function and anemia were present in all Dutch patients, hypomagnesaemia in 5 out of 10. Clinically, all patients responded very well to L‐DOPS, with marked reduction of orthostatic complaints. However, orthostatic hypotension remained present, and kidney function, anemia, and hypomagnesaemia only partially improved. Plasma norepinephrine increased and became detectable, while epinephrine remained undetectable in most patients. We confirm the core clinical characteristics of DBH‐deficiency and the pathognomonic profile of catecholamines in body fluids. Impaired renal function, anemia, and hypomagnesaemia can be part of the clinical presentation. The subjective response to L‐DOPS treatment is excellent and sustained, although the neurotransmitter profile in plasma does not normalize completely. Furthermore, orthostatic hypotension as well as renal function, anemia, and hypomagnesaemia improve only partially.
Binding of direct oral anticoagulants to the FA1 site of human serum albumin
Authors: De Simone Giovanna , Pasquadibisceglie Andrea , di Masi Alessandra , Buzzelli Valeria , Trezza Viviana , Macari Gabriele , Polticelli Fabio , Ascenzi Paolo 
Published: October 2020

AbstractThe anticoagulant therapy is widely used to prevent and treat thromboembolic events. Until the last decade, vitamin K antagonists were the only available oral anticoagulants; recently, direct oral anticoagulants (DOACs) have been developed. Since 55% to 95% of DOACs are bound to plasma proteins, the in silico docking and ligand‐binding properties of drugs apixaban, betrixaban, dabigatran, edoxaban, and rivaroxaban and of the prodrug dabigatran etexilate to human serum albumin (HSA), the most abundant plasma protein, have been investigated. DOACs bind to the fatty acid (FA) site 1 (FA1) of ligand‐free HSA, whereas they bind to the FA8 and FA9 sites of heme‐Fe(III)‐ and myristic acid‐bound HSA. DOACs binding to the FA1 site of ligand‐free HSA has been validated by competitive inhibition of heme‐Fe(III) recognition. Values of the dissociation equilibrium constant for DOACs binding to the FA1 site (ie, calcKDOAC) derived from in silico docking simulations (ranging between 1.2 × 10−8 M and 1.4 × 10−6 M) agree with those determined experimentally from competitive inhibition of heme‐Fe(III) binding (ie, expKDOAC; ranging between 2.5 × 10−7 M and 2.2 × 10−6 M). In addition, this study highlights the inequivalence of rivaroxaban binding to mammalian serum albumin. Given the HSA concentration in vivo (~7.5 × 10−4 M), values of KDOAC here determined indicate that the formation of the HSA:DOACs complexes in the absence and presence of FAs and heme‐Fe(III) may occur in vivo. Therefore, HSA appears to be an important determinant for DOACs transport.