bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental and simulation investigation on BVID and CAI behaviors of CFRP laminates manufactured by RTM technology
Authors: Chen Fang , Yao Weixing , Jiang Wen 
Published: November 2020

Purpose
The purpose of this paper is to synthetically investigate the impact damage responses of carbon fiber reinforced polymer (CFRP) and its influence on the compression mechanical responses of CFRP laminates, including damage distribution, residual compressive strength and fracture morphology.

Design/methodology/approach
A progressive damage simulation model is developed to analyze the complicated damage responses of CFRP laminates that are manufactured by resin transfer method (RTM) technology. Based on the ABAQUS/explicit finite element analysis solver, a VUMAT code is proposed to descript the composite materials’ damage behaviors under both impact and compression load. Adopting this proposed model, the primary mechanical indicators of four groups’ 5284RTM/U3160 CFRP laminates with different stacking sequences are predicted. Moreover, impact and compression after impact tests are conducted to verify the accuracy of simulation results.

Findings
Both simulation and experimental results show that the impact damage with low visible detectability can significantly reduce composites’ compressive strength. For all four groups’ composite laminates, the residual strength ratio is around 35% or even lower. The kernel impact damage near the plates’ geometric center promotes the degradation process of local materials and finally leads to the early occurrence of mechanical fracture. In addition, the impact damage projection area is not sensitive to the parameters of stacking sequences, while the residual compression strength is proportional to the number of 0-degree layers within whole laminates.

Originality/value
This study helps to understand the effect of an impact event on CFRP laminates’ compressive bearing capacity and provides a numerical method in simulating the damage responses under both impact and compression load.
Fumbling in relationships across difference: the potential spiraling effects of a single racial identity reference at work
Authors: Cha Sandra E. , Creary Stephanie J. , Roberts Laura Morgan 
Published: November 2020

PurposeBlack people, as members of a historically underrepresented and marginalized racial identity group in the workplace, are often confronted with identity references – face-to-face encounters in which their race is referenced by a White colleague in a comment, question or joke. Identity references can be interpreted by a Black colleague in a variety of ways (e.g. as hostile and insulting or well-intentioned, even flattering). Identity references can derail the building of relationships across difference, but under certain conditions may open the door for deeper understanding and connection. The conceptual framework in this article delineates conditions under which an identity reference may elicit an initial negative reaction, yet, when engaged directly, may lead to generative experiences and promote higher connection and learning in relationships across difference.Design/methodology/approachThis article builds theory on identity references by incorporating relevant research on race, identity, diversity, attribution and interpersonal relationships at work.FindingsThe framework identifies a common precursor to identity references and three factors that are likely to influence the attribution a Black person makes for a White colleague's identity reference. It then describes how, based on that attribution, a Black person is likely to respond to the White referencer, and how that response is likely to affect their interpersonal relationship over time.Originality/valueBy explicating how a single identity reference can have significant implications for relationships across difference, the framework deepens understanding of how race affects the development of interpersonal relationships between Black and White colleagues at work. In doing so, this article advances research on race, diversity, workplace relationships and positive organizational scholarship.
COVID-19 and residential care facilities: issues and concerns identified by the international network prevention of elder abuse (INPEA)
Authors: Beaulieu Marie , Cadieux Genesse Julien , St-Martin Kevin 
Published: November 2020

PurposeThe COVID-19 pandemic has affected the physical, psychological, social and financial health of older persons. On this subject, the United Nations published a policy brief on the impact of COVID-19 on older persons in May 2020. In line with this, the purpose of this general review is to address three issues affecting older persons living in residential care facilities: protective measures implemented to block the virus’ entry, the types of mistreatment most frequently experienced and the necessity to promote and defend the rights of these persons.Design/methodology/approachThe design of this study is based on input gathered since the end of April during meetings of the International Network for the Prevention of Elder Abuse (INPEA) and the results of a July survey of its members.FindingsThe survey results indicate variability in the implementation of protective measures in different countries and the significant presence of mistreatment and violation of the rights of older persons. Three major issues demand attention: ageism, systemic and managerial problems and the effects of implemented measures. All these prompt the INPEA to once again plea for the adoption of an international convention of human rights of older persons.Originality/valueTo our knowledge, this is the first article sharing the views of the INPEA from a global perspective in the context of COVID-19.
Industry 4.0 collaborative networks for industrial performance
Authors: Dos Santos Leonardo Moraes Aguiar Lima , da Costa Matheus Becker , Kothe João Victor , Benitez Guilherme Brittes , Schaefer Jones Luís , Baierle Ismael Cristofer , Nara Elpidio Oscar Benitez 
Published: November 2020

PurposeAlthough prior studies have identified several technologies related to Industry 4.0 and their individual potential, it is still unclear how these technologies could be integrated to achieve better results. Based on this, we propose several collaborative networks combining technologies associated with Industry 4.0.Design/methodology/approachA literature review was performed using a research model to support the evaluation and identification of key and collaborative technologies related to Industry 4.0. We examined these technologies using hierarchical cluster analysis and principal components analysis, based on their characteristics.FindingsThe study identified big data, cloud computing, the internet of Things and cyber-physical systems as key technologies for Industry 4.0, and a further eight collaborative technologies that are strongly related to industrial performance. We found five collaborative networks with distinct goals in the context of Industry 4.0: (1) smart manufacturing; (2) technological platforms; (3) market reactiveness; (4) smart products and (5) flexibility.Practical implicationsThe findings allowed us to create five pathways for future work on Industry 4.0 technologies via collaborative networks. In practice, this will help managers to improve their focus on priorities regarding the implementation of Industry 4.0 technologies.Originality/valueThis study provides insights into how to establish links between technologies through collaborative networks for certain purposes. In addition, we propose five future directions for these collaborative networks that require further investigation by researchers.
Customer acceptance of ride-hailing in Indonesia
Authors: Almunawar Mohammad Nabil , Anshari Muhammad , Ariff Lim Syamimi 
Published: November 2020

Purpose
The purpose of this paper is to investigate the enabling factors and the customers’ acceptance of ride-hailing in Indonesia.

Design/methodology/approach
The authors adopt some constructs from the unified theory of acceptance and use of technology (UTAUT) 2 as the framework for the study to derive factors that influence the acceptance of ride-hailing in Indonesia. Samples through a convenience sampling method were collected from an online survey and were transformed into data through coding and subsequently processed using SPSS for descriptive analysis, reliability test, correlation and multiple regression analysis for hypothesis testing.

Findings
Ride-hailing started in 2015 in Indonesia. Five enabling factors make digital ride-hailing possible, the internet, smartphone, broadband wireless network, digital map and global positioning system. The authors found that performance expectancy, social influence and habit positively influence customers to accept ride-hailing in Indonesia.

Research limitations/implications
Although this research has a small sample, it is still relevant to understand people’s acceptance to the ride-hailing platform. As a ride-hailing platform is now transformed to a multisided markets platform, adoption studies or other studies on each market to cover the whole picture of the platform influence to the society, and its contribution to the national economy will be very interesting. The authors’ future research will cover various services covered by ride-hailing companies.

Originality/value
This study proposes and argues that four main enabling factors make digital ride-hailing a viable business. The study contributes to three significant factors that influence the acceptance of ride-hailing in Indonesia.
Experiencing career plateau on a committed career journey: a boundary condition of career stages
Authors: Lin Yi-chun , Chen Angela Shin-yih 
Published: November 2020

PurposeCareer plateau is a major concern for many seasoned employees because they often stay in the same position longer than expected and over time begin to lack job challenges. This phenomenon is now considered a normal stage in career development. The purpose of this study is to test the effects of two types of career plateau: hierarchical and job content on career commitment (career identity, career insight and career resilience), along with the mediating effect of perceived external employability. We also determined in the moderated mediation model if Super's (1957) three career stages amplify and attenuate the indirect effect of hierarchical/job content plateau on career commitment (career identity, career insight, career resilience) via perceived external employability.Design/methodology/approachWe tested the hypotheses with survey data collected from a convenience sample of 472 white-collar full-time employees who also studied in the MBA and continuing education program in five large universities in Taiwan (77% return rate).FindingsThe mediation model result showed that perceived external employability partially and negatively mediated the influence of hierarchical plateaus on career commitment (career identity, career insight and career resilience). Perceived external employability partially and negatively mediated the influence of job content plateaus on career identity and career insight but fully and negatively mediated on career resilience. The result of the moderated mediation model also demonstrated that only employees in the trial stage had influences on the mediation relationships among the hierarchical plateau, perceived external employability and career commitment with its two dimensions of career identity and career insight only other than those in the stabilization and maintenance stages.Practical implicationsThe findings of this study can benefit career management scholars and practitioners since they promote a better understanding of the career management practices that are relevant for seasoned employees who are valued for their knowledge, experience and expertise when encountering the three career stages.Originality/valueDrawing on the conservation of resources (COR) theoretical perspective, we fill the gap in the literature by proposing perceived external employability as a mediator in the link between career plateau and career commitment and generalize the results to plateaued employees at the different career stages.
Assistive cane for visually impaired persons for uneven surface detection with orientation restraint sensing
Authors: Singh Bhupendra , Kapoor Monit 
Published: November 2020

Purpose
The reduced ability of eyes to see clearly even with the use of glasses is known as the state of visual impairment. Among the many challenges faced, outdoor travel is one of them requiring to travel through surfaces, which has potholes and bumps.

Design/methodology/approach
The depth of the pothole and height of the bump is also conveyed to the user through different vibration pattern of various intensity. With available electronic travel aids, the visually impaired persons are still more inclined to rely on their white cane than carrying additional equipment for obstacle avoidance. In the system, all the components can be attached to the white cane, requiring no additional device to carry.

Findings
Upon experimentation with different obstacle types, the system obtained a 24.88% higher score in comparison to normal walking cane. A comparison with the state of the art available systems is also provided.

Originality/value
Moreover, the accuracy of the assistive cane can be heavily degraded if the cane is not properly held by the user. To restrict the user to hold the cane in only required orientation an alignment sensing switch is also proposed, which is missing in the current available literature.
Case series of BRAF‐mutated advanced melanoma treated with encorafenib plus binimetinib combination therapy
Authors: Fujimura Taku , Yoshino Koji , Kato Hiroshi , Fujisawa Yasuhiro , Nakamura Yoshiyuki , Yamamoto Yuki , Kunimoto Kayo , Ito Takamichi , Matsushita Shigeto , Maekawa Takeo , Ohuchi Kentaro , Amagai Ryo , Muto Yusuke , Furudate Sadanori , Kambayashi Yumi , Hashimoto Akira , Aiba Setsuya 
Published: November 2020

AbstractThe efficacy of encorafenib plus binimetinib (E + B) combination therapy for BRAF‐mutated advanced melanoma as second‐line therapy and beyond is still unknown. In this report, we investigated 22 cases of BRAF‐mutated advanced melanoma treated with E + B combination therapy. The objective response rate (ORR) for the total cohort was 68.4%. Notably, the ORR for the second‐line and beyond cohort was 73.3%, suggesting that the therapeutic effect of E + B combination therapy is comparable with that of first‐line targeted therapy. In contrast, overall survival and progress‐free survival in our present cohort was worse than that in a previous clinical trial. Notably, although the incidence rate of severe adverse events was higher than that in a previous report, our present study suggested that E + B combination therapy is a well‐tolerated antimelanoma regimen. Our present study suggested that the efficacy and safety profile of E + B combination therapy as a second‐line therapy and beyond is comparable with that of first‐line targeted therapy.
Fluid escapes to the “third space” during anesthesia, a commentary
Authors: Hahn Robert G. 
Published: November 2020

BackgroundThe “third fluid space” is a concept that has caused much confusion for more than half a century, dividing anesthesiologists into believers and non‐believers.AimTo challenge the existence of the “third fluid space” based on analysis of crystalloid fluid kinetics.MethodsData on hemodilution patterns from 157 infusion experiments performed in volunteers and from 85 patients undergoing surgery under general anesthesia were studied by population volume kinetic analysis. Elimination of infused crystalloid fluid from the kinetic model could occur either as urine or "third space" accumulation. The latter fluid volume remained in the body, but without equilibrating with the plasma within the 3‐4 h of the experiment.ResultsThe rate constant for "third space" loss of fluid accounted for 20% of the elimination in conscious volunteers and for 75% during general anesthesia and surgery. The two elimination constants showed a reciprocal relationship, resulting in that "third‐space" losses increase when urinary excretion is restricted. The effect on the plasma volume was smaller than indicated by these figures because fluid distributed to the extravascular space continuously redistributed to the plasma. Worked‐out examples show that one‐third of an infused crystalloid volume has been confined to the "third space" after 3 h of surgery. When equilibration with the plasma eventually occurs, which is necessary for excretion of the fluid, is not known.ConclusionDuring anesthesia and surgery one third of the infused crystalloid fluid is at least temporarily unavailable for excretion, which probably contributes to postoperative weight increase and edema.
Patient‐reported oral hygiene and implant outcomes in general dental practice
Authors: Cheung Monique Charlene , Hopcraft Matthew S. , Darby Ivan B. 
Published: November 2020

AbstractBackgroundThis study investigated the possible correlations between patient‐performed implant hygiene and peri‐implant success and disease, as well as patient‐reported outcomes, in a community‐based cohort.MethodsFifty‐one patients (78 implants) from two private general practices were surveyed on their dental implant treatment history, oral hygiene instructions (OHI) received, home hygiene habits and current implant concerns. Their dentition, plaque/calculus scores and clinical implant parameters were examined. Correlations between hygiene habits, risk factors, implant success and peri‐implant disease rates were assessed.ResultsImplants had a patient‐reported mean time in function of 6.7 years. Floss (74.4%), interdental brushes (IDB) (44.9%) and mouthwash (39.7%) were commonly used, while 7.7% of implants were only cleaned by brushing. Over half (56.4%) of implants fulfilled the success criteria, 61.5% had peri‐implant health, 24.4% had mucositis and 7.7% had peri‐implantitis. Only brushing (P < 0.001) and detectable plaque/calculus (P < 0.001) were significantly associated with more peri‐implant disease. Local prosthetic factors affecting cleaning accessibility significantly reduced implant success (P < 0.001). Patients reported mixed recall of implant OHI, 7.7% of implants were aesthetically unsatisfactory and 9.0% had peri‐implant symptoms.ConclusionsLack of interproximal cleaning and the presence of plaque/calculus were significantly associated with peri‐implant disease in a community‐based general practice setting, and patients reported mixed recall of OHI.
Exploring the limits of prolonged apnoea with high‐flow nasal oxygen: an observational study
Authors: Piosik Z. M. , Dirks J. , Rasmussen L. S. , Kristensen C. M. , Kristensen M. S. 
Published: November 2020

SummaryHigh‐flow nasal oxygen is increasingly used for oxygenation during apnoea. Extending apnoea duration using this technique has mainly been investigated during minor laryngeal surgery, but it is unclear how long it can be administered for before it should be discontinued due to acidosis. We aimed to describe the dynamics of arterial blood gases during apnoeic oxygenation with high‐flow nasal oxygen with jaw thrust only, to explore the limits of this technique. We included adult orthopaedic patients scheduled for general anaesthesia. After pre‐oxygenation, anaesthesia with neuromuscular blockade was induced and high‐flow nasal oxygen (70 l.min−1) was continued with jaw thrust as the only means of airway management, with monitoring of vital signs and arterial blood gas sampling every 5 minutes. Apnoeic oxygenation with high‐flow nasal oxygen was discontinued when arterial carbon dioxide tension (PaCO2) exceeded 12 kPa or pH fell to 7.15. This technique was used in 35 patients and median (IQR [range]) apnoea time was 25 (20–30 [20–45]) min and was discontinued in all patients when pH fell to 7.15. The mean (SD) PaCO2 increase was 0.25 (0.06) kPa.min−1 but it varied substantially (range 0.13–0.35 kPa.min−1). Mean (SD) arterial oxygen tension was 48.6 (11.8) kPa when high‐flow nasal oxygen was stopped. Patients with apnoea time > 25 minutes were significantly older (p = 0.025). We conclude that apnoeic oxygenation with high‐flow nasal oxygen resulted in a significant respiratory acidosis that varies substantially on the individual level, but oxygenation was maintained.
Camostat mesylate against SARS‐CoV‐2 and COVID‐19—Rationale, dosing and safety
Authors: Breining Peter , Frølund Anne Lier , Højen Jesper Falkesgaard , Gunst Jesper Damsgaard , Staerke Nina B. , Saedder Eva , Cases‐Thomas Manuel , Little Paul , Nielsen Lars Peter , Søgaard Ole S. , Kjolby Mads 
Published: November 2020

AbstractThe coronavirus responsible for COVID‐19, SARS‐CoV‐2, utilizes a viral membrane spike protein for host cell entry. For the virus to engage in host membrane fusion, SARS‐CoV‐2 utilizes the human transmembrane surface protease, TMPRSS2, to cleave and activate the spike protein. Camostat mesylate, an orally available well‐known serine protease inhibitor, is a potent inhibitor of TMPRSS2 and has been hypothesized as a potential antiviral drug against COVID‐19. In vitro human cell and animal studies have shown that camostat mesylate inhibits virus‐cell membrane fusion and hence viral replication. In mice, camostat mesylate treatment during acute infection with influenza, also dependent on TMPRSS2, leads to a reduced viral load. The decreased viral load may be associated with an improved patient outcome. Because camostat mesylate is administered as an oral drug, it may be used in outpatients as well as inpatients at all disease stages of SARS‐CoV‐2 infection if it is shown to be an effective antiviral agent. Clinical trials are currently ongoing to test whether this well‐known drug could be repurposed and utilized to combat the current pandemic. In the following, we will review current knowledge on camostat mesylate mode of action, potential benefits as an antiviral agent and ongoing clinical trials.
The epidemiology of eczema in children and adults in England: A population‐based study using primary care data
Authors: de Lusignan Simon , Alexander Helen , Broderick Conor , Dennis John , McGovern Andrew , Feeney Claire , Flohr Carsten 
Published: November 2020

AbstractBackgroundWhilst eczema is a common inflammatory skin condition, we lack contemporary estimates of disease incidence and prevalence across the lifespan.ObjectiveTo estimate the incidence and prevalence of eczema in children and adults in England and variation by sociodemographic factors (sex, socio‐economic status, ethnicity, and geography).MethodsWe used the Royal College of General Practitioners Research and Surveillance Centre primary care research database of 3.85 million children and adults registered with participating general practitioner practices between 2009 and 2018 inclusive. Eczema incidence was defined as the first‐ever diagnosis of eczema recorded in the primary care record, and eczema prevalence was defined as fulfilment of criteria for active eczema (two eczema records appearing in the primary care record within any one‐year period).ResultsEczema incidence was highest in infants younger than 1 year (15.0 per 100 person‐years), lowest in adults aged 40–49 (0.35 p/100 person‐years), and increased from middle age to a second smaller peak in people 80 years or older (0.79 p/100 person‐years). Eczema prevalence was highest in children aged 2 (16.5%) and lowest in adults aged 30–39 (2.8%). Eczema incidence was higher in male infants (<2) and male adults older than 70; for all other ages, incidence was higher in females. Eczema was more common in Asian and black ethnic groups than in people of white ethnicity. Higher socio‐economic status was associated with a greater incidence of eczema in infants younger than 2, but the reverse was seen for all other age groups. Both incidence and prevalence of eczema were greater in urban settings and in North‐West England.Conclusions and Clinical RelevanceEczema has a bimodal distribution across the lifespan. We observed differences in incidence and prevalence of eczema by ethnicity, geography, sex, and socio‐economic status, which varied in magnitude throughout life.