bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emprendimiento para Mujeres a Través del Aprovechamiento de un Subproducto de la Hoja de Arándano Azul (Vaccinium Corymbosum)
Authors: Cabrera Ramírez Ariadna , García Mayra Nicolás , Villalobos Espinosa Julieta del C. 
Published: December 2024

En 2023 la Encuesta Nacional de Ocupación y Empleo mencionó que 77 de cada 100 hombres en edad de trabajar fueron económicamente activos, mientras que en el caso de las mujeres 46 de cada 100 en edad de trabajar se encuentran en el mercado laboral. Por lo anterior, es apremiante mejorar su calidad de vida a través de impulsar su emprendimiento, principalmente en zonas rurales, por otro lado, en puebla la producción de arándano azul (Vaccinium corymbosum) ocupa el 1er° lugar, este cultivo es de interés comercial, sin embargo, el manejo inadecuado del desecho impacta negativamente al medio ambiente. Por ello, es importante el aprovechamiento de estos residuos para la elaboración de un producto que permitirá beneficiar los hábitos de consumo saludable en las personas, además de que incorpora a mujeres en el proceso de elaboración y comercialización; para tal efecto, se consideró como objetivo elaborar un lienzo eco-canvas que permita impulsar el emprendimiento en mujeres a través del aprovechamiento de un subproducto e investigar los compuestos fenólicos de las hojas de arándano. Para el lienzo eco-canvas se empleó la metodología descriptiva con enfoque cualitativo, se estableció al identificar las áreas específicas que permiten potenciar el valor del producto a través de la creación de valor, los problemas que resuelve es establecer los escenarios de posicionamiento del producto innovador y saludable, así como estimular el emprendimiento, los resultados permitieron visualizar elementos más precisos para que el producto sea aceptado por un sector específico de consumidores, por otro lado, también se realizó la extracción de compuestos fenólicos empleando 3 metodologías por maceración en una relación 1:10 (p/v) y diferentes soluciones extractoras bajo la oscuridad.
Bilateral Ectasia After SMILE Combined With Accelerated Corneal Cross-linking (SMILE-Xtra)
Authors: Pagano Luca , Vinciguerra Paolo , Fantozzi Marco , Catanese Anna Maria , Vinciguerra Riccardo 
Published: December 2024

Purpose
To present the first reported case of bilateral ectasia following small incision lenticule extraction (SMILE) associated with corneal cross-linking (CXL).

Methods
A 20-year-old woman was referred for bilateral corneal ectasia 2 years after uneventful bilateral SMILE combined with accelerated CXL (SMILE-Xtra) for myopic correction. The preoperative refraction was −3.00 −0.75 × 10° in the right eye and −2.50 −0.50 × 165° in the left eye. The preoperative corneal topography showed a minimum corneal thickness of 488 µm in the right eye and 498 µm in the left eye.

Results
Initial follow-up results showed stable visual acuity, but she presented 24 months later with reduced vision in the left eye, revealing bilateral ectasia. Scheimpflug examination confirmed central ectasia in the left eye and subtle initial ectasia in the right eye. Biomechanical analysis demonstrated altered parameters and epithelial mapping revealed epithelial thinning.

Conclusions
This study challenges previous assertions about the efficacy of SMILE-Xtra in preventing ectasia, because it presents the first documented case of this complication. The findings emphasize the importance of exercising caution in treating corneas at risk, regardless of the association of CXL, especially when the cornea is considered suspicious. This highlights a broader concern that all refractive surgeries may carry a risk of inducing ectasia, underscoring the necessity for careful patient selection and continuous refinement of surgical protocols for optimal safety outcomes.

[
Journal of Refractive Surgery Case Reports.
2024;4(4):e40–e45.]
A novel study of the impact of supply chain complexity on the bullwhip effect
Authors: El-Beheiry Mohammed , Taha Raghda , Ismail Tamer , Adel Yasmin 
Published: December 2024

Background: The coronavirus pandemic exposed global supply chain vulnerabilities, causing fluctuating demand for products. This resulted in the bullwhip effect, which posed a substantial challenge for supply chain management. This study focusses on the analysis of the effect of supply chain configurations and structure on the bullwhip effect.Objectives: The research quantitatively studies the effect of the strategic supply chain structure at the design phase on amplifying the bullwhip effect. Furthermore, it studies the expected interaction during operation, which may further amplify or dampen it.Method: The study introduces a simulation model and examines the influence of several design decisions and operations parameters and their interactions on the efficiency of supply chain operations. A simulation model is created for several supply chain configurations, each with distinct structure complexity. The bullwhip effect measures are collected and a factorial analysis is conducted to examine the interactions among the parameters and their impact on the performance.Results: The findings indicate that an increase in demand unpredictability results in a greater bullwhip effect, irrespective of the inventory strategy or structural intricacy. But the level of increase does not necessarily match the increase in complexity and can be amplified or damped by interactions between operating parameters.Conclusion: Supply network architects should consider the level of structural complexity to mitigate amplifications of demand variations and to optimise the supply chain’s overall operation.Contribution: The research represents a novel work to quantitatively link the bullwhip effect of a supply chain to the complexity of its supply chain structure.
Incidence and Nature of Neurological Complications among Coronavirus Disease 2019 Intensive Care Unit Patients in Saudi Arabia: A Retrospective Analysis
Authors: Aleid Abdulsalam Mohammed , Alhazzaa Alwaleed Abdullah , Alahmadi Yasser Saud , Aldehaim Fahad Mohammed , Almesned Bishri Fawzan , Allowaihiq Lujain Habeeb , Alsharif Lana Zaid , Alalwan Walaa Ibrahim Mohammed , Kharaba Ayman , Almalki Sami 
Published: December 2024

Abstract

Introduction:
Coronavirus disease 2019 (COVID-19) represents a global health challenge. Neurological complications arising due to SARS-CoV-2 infection or its systemic manifestations complicate clinical course and prognosis. This study characterised the incidence and impact of neurological complications on outcomes among critically ill COVID-19 patients in Saudi Arabia.

Methods:
This retrospective study examined data from 1086 adult COVID-19 patients admitted to intensive care units (ICUs) of tertiary hospitals between 22 June 2020 and 22 October 2020. Patient demographics, comorbidities, neurological complications, lengths of stay, need for mechanical ventilation (MV) and outcomes were retrieved. Neurological outcomes studied included stroke, seizures and intracerebral haemorrhage. The study utilised IBM SPSS Statistics version 27 for statistical analysis, focusing on clinical features, neurological complications, demographics and patient outcomes. Categorical variables were expressed as frequencies and percentages, whereas continuous variables were shown as means and standard deviations. Neurological complication incidence rates were computed, and associations were determined using Chi-square tests. Comparisons between groups were performed using one-way analysis of variance with post hoc tests. Multiple logistic regression assessed the impact of neurological complications on outcomes, whereas Kaplan–Meier curves and log-rank tests were used for survival analysis.

Results:
The mean age was 55 years with male preponderance. Overall neurological complication incidence was 2.6% for stroke, 1.8% for seizures and 2.8% for intracerebral haemorrhage. Lengths of stay and ventilation duration were significantly prolonged among patients with the above complications compared to those without. Stroke influenced microbiological cure rates, with more patients achieving cure without stroke. Patients with stroke, seizures or intracerebral haemorrhage had lower rates of ICU discharge within 28 days and higher mortality.

Conclusion:
Neurological involvement independently impacted the clinical course and survival in critically ill COVID-19 patients. Stroke, seizures and intracerebral haemorrhage acted as risk factors for adverse outcomes by prolonging recovery, MV requirement and increasing mortality. Longer stays incurred by neurological issues reinforce the need for vigilant monitoring, multidisciplinary care and resource allocation. Strategies accounting for neurological involvement can help optimise care pathways and improve prognosis.
Unlocking the benefits of Drug Master File filing in the Indian pharmaceutical industries
Authors: Pathak Rahul , Singal Rajat , Mitra Sandip , Koul Sanjay , Sharma Supriya 
Published: December 2024

Abstract
Ensuring the safety and quality of drugs is a crucial component for the development of any pharmaceutical industry. This requires stringent regulation in the process of drug manufacturing and marketing. A Drug Master File (DMF) serves as a comprehensive document containing information about the quality, safety, and manufacturing procedure/facility of a drug or drug substance. Many countries with highly regulated markets use the DMF system extensively to protect their intellectual property rights while providing accurate and detailed information about their products to regulatory bodies. In India, the regulatory body, the Central Drug Standard Control Organization, does not currently mandate the submission of a DMF. However, adopting a DMF system may have immense benefits to regulatory bodies, pharmaceutical industries, as well as to patients. This review aims to provide a comprehensive overview of DMF and highlight the significance of its adoption in India.
The role of very low-dose prophylaxis in severe hemophilia patients
Authors: Aggarwal Sunita , Tomar Anshul , Kumar Kapil , Kumar Ankitesh , Kumar Suresh , Garg Sandeep , Kumar Naresh , Nandi Sudipta 
Published: December 2024

Abstract

INTRODUCTION:
Very low-dose prophylaxis of antihemophilic factor (AHF) in hemophilia involves administration of minimal amounts of clotting factor concentrates, typically below standard doses, to maintain baseline levels and reduce bleeding episodes. This method uses smaller, more frequent doses to balance bleeding prevention and cost-effectiveness. Close monitoring ensures adequate protection while avoiding overtreatment, offering a tailored, cost-effective approach to improve the quality of life (QoL) of the hemophiliacs.

AIM:
The study aims to study the bleeding risks in patients with severe hemophilia who are on very low-dose AHF prophylaxis. It also seeks to assess the annual consumption of AHF in the hemophiliacs. In addition, the research will determine the QoL in both groups using the social functioning (SF)-36 questionnaire,evaluate patient compliance with the prophylactic regimen, and check functional disability using the Functional Independence Score in Hemophilia (FISH).

MATERIALS AND METHODS:
The patients selected for the study were diagnosed with cases of hemophilia and were planned for any surgical procedure. The study was a cross-sectional study lasting 12 months. Patients over 13 years were included and patients with any other bleeding tendencies were excluded from the study.

RESULTS:
The differences found in the study, were significant in terms of annual bleed rate (ABR), amount of AHF consumed, SF-36, and FISH scores.

CONCLUSION:
Our study found that very low-dose prophylaxis significantly reduced the ABR in hemophilia patients. Functional independence worsened in the control group but remained stable in the test group, which showed significant improvements in SF-36 domains. The test group had no inhibitor development and showed a decline in severe bleeds, proving the efficacy and superiority of low-dose prophylaxis over on-demand therapy.
Novel insights into non-coding RNAs and their role in hydrocephalus
Authors: Cui Zhiyue , He Jian , Li An , Wang Junqiang , Yang Yijian , Wang Kaiyue , Liu Zhikun , Ouyang Qian , Su Zhangjie , Hu Pingsheng , Xiao Gelei 
Published: December 2024

Abstract
A large body of evidence has highlighted the role of non-coding RNAs in neurodevelopment and neuroinflammation. This evidence has led to increasing speculation that non-coding RNAs may be involved in the pathophysiological mechanisms underlying hydrocephalus, one of the most common neurological conditions worldwide. In this review, we first outline the basic concepts and incidence of hydrocephalus along with the limitations of existing treatments for this condition. Then, we outline the definition, classification, and biological role of non-coding RNAs. Subsequently, we analyze the roles of non-coding RNAs in the formation of hydrocephalus in detail. Specifically, we have focused on the potential significance of non-coding RNAs in the pathophysiology of hydrocephalus, including glymphatic pathways, neuroinflammatory processes, and neurological dysplasia, on the basis of the existing evidence. Lastly, we review the potential of non-coding RNAs as biomarkers of hydrocephalus and for the creation of innovative treatments.
Assessment of Efficacy of Six Different Moisturizing Creams in Maintaining the Hydration of Skin in Healthy Human Volunteers
Authors: Dashore Shuken , Pande Sushil , Lambghare Nancy 
Published: December 2024

Introduction:
Moisturizers are routinely prescribed so for adequate hydration of the skin. There are various preparations of these moisturizers in the market making it difficult for a dermatologist to choose the most effective moisturizer.

Objectives:
To compare the efficacy of six different commonly used commercial and prescription based skin moisturizers.

Materials and Methods:
A total of 30 human healthy volunteers of the same age group were enrolled in a study. We selected six sites on the dorsum of hand (A, B, C, D, E, and F) for the application of moisturizers. In this study, we used six different commercially available moisturizers namely Emoderm® cream, Secalia® cream, Amylac® 12% cream, Ponds® cream, Nivea® cream, Dove® cream. Baseline moisture level reading of the areas selected was taken (A, B, C, D, E, and F) with the help of digital skin moisture analyzer. Digital skin moisture analyzer is a portable device that uses bioelectric impedance analysis technology. Readings were taken at the end of 15 min, 30 min, and 1 h after application of the cream.

Results:
At the end of 15 min, only Dove moisturizer could retain the baseline moisture level in the skin without positive or negative change. Moisture levels were reduced in other groups. At the end of 30 min, Secalia® moisturizer produced an increase in moisture level over the baseline - 4.76%. Moisture levels were below baseline in other groups. Secalia® moisturizer produced the maximum increase in moisture level over the baseline at the end of 1 h - 21.99%. The only other moisturizers to produce moisture level above baseline after 60 min were Dove® 5.02% and Amylac®- 5.66%.

Conclusion:
We conclude that epidermal hydration produced by moisturizers influences the electrical properties of skin. Humectants cause a significant increase in moisture levels as assessed by digital skin moisture analyzer.
Upaya Meningkatkan Minat Belajar Siswa Kelas 8c Dalam Pendidikan Agama Kristen Melalui Strategi Pembelajaran Berbasis Masalah Di Sekolah Menengah Pertama BOPKRI 3 Yogyakarta
Authors: Anggreni Intan , Tandana Ester Agustini , Basuki Eko , Liantoro Liantoro , Jayadi Lionarto Erson 
Published: December 2024

This study aims to improve the learning interest of class 8C students in the subject of Christian Religious Education at SMP BOPKRI 3 Yogyakarta through the implementation of Problem-Based Learning (PBL) strategies. The research method used is classroom action research (CAR) which consists of several cycles, each covering the stages of planning, implementation, observation, and reflection. The results of the study indicate that the implementation of PBL is effective in improving students' learning interest. Students are more actively involved in the learning process, show improvements in critical thinking skills, and are more enthusiastic in solving problems related to the subject matter. This improvement is reflected in better academic grades and student activity during the learning process. In addition, supporting factors such as teacher support in guiding discussions, the use of interesting learning media, and a conducive classroom atmosphere also contribute to increasing students' learning interest. This study is that the Problem-Based Learning strategy is effective in improving the learning interest of class 8C students in Christian Religious Education. Recommendations for further research are to adopt PBL in other subjects and expand the use of learning media to further increase student engagement and interest in learning.

Keywords: Learning interest, Christian Religious Education, Problem-Based Learning (PBL), classroom action research, junior high school students.

Penelitian ini bertujuan untuk meningkatkan minat belajar siswa kelas 8C dalam mata pelajaran Pendidikan Agama Kristen di SMP BOPKRI 3 Yogyakarta melalui penerapan strategi Pembelajaran Berbasis Masalah (PBM). Metode penelitian yang digunakan adalah penelitian tindakan kelas (PTK) yang terdiri dari beberapa siklus, masing-masing mencakup tahap perencanaan, pelaksanaan, observasi, dan refleksi. Hasil penelitian menunjukkan bahwa penerapan PBM efektif dalam meningkatkan minat belajar siswa. Siswa lebih aktif terlibat dalam proses pembelajaran, menunjukkan peningkatan dalam kemampuan berpikir kritis, dan lebih antusias dalam menyelesaikan masalah yang berkaitan dengan materi pelajaran. Peningkatan ini tercermin dalam nilai akademik yang lebih baik dan keaktifan siswa selama proses pembelajaran. Selain itu, faktor-faktor pendukung seperti dukungan guru dalam membimbing diskusi, penggunaan media pembelajaran yang menarik, dan suasana kelas yang kondusif juga berkontribusi terhadap peningkatan minat belajar siswa. Penelitian ini adalah bahwa strategi Pembelajaran Berbasis Masalah efektif dalam meningkatkan minat belajar siswa kelas 8C dalam Pendidikan Agama Kristen. Rekomendasi untuk penelitian selanjutnya adalah mengadopsi PBM dalam mata pelajaran lain dan memperluas penggunaan media pembelajaran untuk lebih meningkatkan keterlibatan dan minat belajar siswa.
Exploring the Impact of Eco-Friendly Leadership and Motivation on Sustainable Workplace Culture and Environmental Effectiveness to Support the Sustainable Development Goals (SDG’s)
Authors: Hardiyana Aan , Manik Ester , Komara Anton Tirta 
Published: December 2024

Objective: This study investigates the effects of Green Transformational Leadership, Green Intrinsic Motivation, and Green Extrinsic Motivation on pro-environmental workplace behaviors in Bandung City, Indonesia's creative economy. It is in line with the Sustainable Development Goals (SDGs).

Theoretical Framework: This study is founded on the ideas of environmental performance, workplace pro-environmental behaviors, green transformational leadership, and green motivation (both intrinsic and extrinsic), all of which support sustainable practices in line with the SDGs.

Method: Utilizing a survey approach, this research targets employees in the creative industry's fashion sector in Bandung City, Indonesia, encompassing sub-sectors like fashion, knitting, footwear, and accessories. The study aims to involve 312 willing participants and employs Confirmatory Factor Analysis and Covariance-Based Structural Equation Modeling (CB-SEM) methodologies.

Results and Discussion: The report indicates that green transformational leadership, green intrinsic and extrinsic motivation, workplace pro-environmental behaviors, and environmental performance are all highly correlated. This draws attention to the study's contribution to the SDGs.

Research Implications: While acknowledging limitations such as sector-specific generalizability and potential biases in data collection methods, this study highlights the need to expand respondent samples across industries to enhance the applicability of findings and promote sustainable practices in alignment with the SDGs.

Originality/Value: This study enhances the existing body of knowledge by examining the relationship between green transformational leadership, green intrinsic and extrinsic motivation, workplace pro-environmental behaviors, and environmental performance within Bandung City's creative industry. It emphasizes how crucial motivation and leadership are to encouraging eco-friendly behavior and enhancing environmental performance, which supports the SDGs.
Blockchain in Agricultural Supply Chain: Promote the UN Sustainable Development Goals (SDGS)
Authors: Yuan Fang 
Published: December 2024

Objective: This study aims to evaluate the possibility of Blockchain promoting the UN Sustainable Development Goals (SDGs).

Theoretical Framework: Based on the characteristics of blockchain, the content of SDGs, and various theories of new technology and social sustainable development, this study explores how blockchain can be used as instrument in smart regulatory theory to promote SDGs.

Method: The analysis is combined with theory and specific fields to evaluate the possibility of blockchain acting as instrument to promote corporate self-regulation for sustainable development, and to specifically analyze smart contracts and Hyperledger Fabric in the agricultural supply chain to promote SDGs.

Results and Discussion: The discussion results show that in theory, blockchain could become a regulatory instrument as a technical link; in practice, smart contracts and Hyperledger Fabric can help solve specific problems in the agricultural supply chain and promote the realization of ‘Good Health and Well-being’ and ‘Responsible Consumption and Production’.

Research Implications: This study contributes to the use of blockchain as regulatory instrument to promote corporate self-regulation and helps to provide ideas for the realization of SDGs and the resolution of specific difficulties in the agricultural supply chain.

Originality/Value: This study contributes to the application of blockchain, the promotion of SDGs, and the interaction between technology and social development.
Effect of Height and Cutting Intervals on the Yield (Kg/Ha) of Green Biomass And Nutritional Quality of Cuba 22 Elephant Grass
Authors: Henríquez José Luis Guillén , Villegas Miguel Alexander Quintanilla 
Published: December 2024

Objectives: This study investigates the effects of two cutting heights and three cutting intervals on the green biomass yield and nutritional quality of Elephant Grass, Cuba 22 variety, in Victoria, Cabañas, El Salvador.

Theoretical Framework: Proper management of Elephant Grass is essential for optimizing forage production. Cutting height and interval impact biomass yield and nutritional quality, influencing livestock feeding efficiency and contributing to sustainable agriculture, aligned with SDG 2: Zero Hunger.

Method: A factorial A2xB3 design was used to analyze the effect of two cutting heights (0.1 m and 0.2 m) and three cutting intervals (40, 50, and 60 days) on the yield and quality of Elephant Grass. The main effects and interactions between these variables were evaluated.

Results and Discussion: The combination of a low cutting height (0.1 m) and a 50-day interval maximizes biomass yield and preserves nutritional quality, while 60-day intervals increase biomass but reduce its nutritional value, affecting livestock feed.

Implications: The study provides recommendations to optimize forage production and contribute to food security, enhancing agricultural productivity and animal nutrition in line with SDG 2.

Originality: This is an original study in El Salvador that evaluates how cutting height and interval influence the yield and quality of Elephant Grass, promoting sustainable practices.