bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of angiogenesis as a prognostic marker in prostatic neoplasm especially carcinoma of prostate
Authors: Prakash Surya , Shevra Chhaya Rani , Nath Dwijendra 
Published: October 2019

Background: Prostatic carcinoma shows an unusually wide range of biological potential with well-known disparity between incidence and mortality for disease. Clinico-pathological studies suggests that angiogenesis and tumor neovascularity contributes to pathogenesis of prostate cancer. The aim of this study to present study was done to assess the validity of angiogenesis as a suitable prognostic marker in various prostatic disease specially the neoplasm’s including the malignant ones. Settings and design are Retrospective study.Methods: The present study of evaluation of angiogenesis as a prognostic marker in prostatic neoplasm especially carcinoma of prostate was done with 40 biopsy sample. The biopsy sample were obtained by suprapubic prostatectomy specimen and trans rectal needle biopsy specimen. Tissue sections were subjected to routine H and E staining. For demonstration of angiogenesis staining for reticulin fibers was applied.Results: The microvessels density increases as the severity of lesion increases from benign to pre-neoplastic to frankly malignant. The micro vessel density in malignant lesions is approximately thrice that in benign lesions. Conclusions: Very few studies have been done in prostatic lesions Hence an attempt is made to demonstrate and correlate angiogenesis as a tumour marker.
Traheobronchial foreign bodies: evaluation and retrieval by rigid bronchoscopy
Authors: Dolma Kunzes , Gupta Anchal , Gupta Apurab , Jamwal Padam Singh 
Published: October 2019

<p class="abstract"><strong>Background:</strong> The foreign body aspiration is one of the commonest ENT emergencies. Delay in diagnosis and treatment may lead to significant morbidity and mortality.</p><p class="abstract"><strong>Methods:</strong> The current study was conducted at Department of Otorhinolaryngology and Head and Neck Surgery, SMGS Hospital, Government Medical College, Jammu, from November 2017 to October 2018. All symptomatic patients diagnosed with foreign body aspiration on the basis of history, clinical examination and radiological evaluation and who underwent rigid bronchoscopic retrieval were included in the study. Fifty patients were studied. </p><p class="abstract"><strong>Results:</strong> The majority of patients 33 (66%) were between 1 and 3 years of age.12 (24%) patients were over 3 years of age with oldest of 57 years old age with male: female ratio of 2.1:1. The clinical features of these patients were mainly cough, respiratory distress, wheeze, fever, stridor, choking and cyanosis. On bronchoscopy, foreign body was identified in 46 (92%) patients and no foreign body was seen in 4 (8%) patients with suspected foreign body aspiration. The most common type of foreign body was organic (73.91%), with peanuts (47.82%) being the commonest. The most common site was left bronchus seen in 22 (47.83%) patients followed by right bronchus seen in 18 (39.13%) and trachea seen in 6 (13.04%) patients. Overall mortality and morbidity rates were 2.17% and 4.35% respectively.</p><p><strong>Conclusions:</strong> History and clinical examination should be more relied upon as diagnostic tool than radiological findings in diagnosing foreign body inhalation. Rigid bronchoscopic removal of foreign body is the standard procedure for removing tracheobronchial foreign bodies. </p>
Head and neck carcinoma and its association with environmental factors
Authors: Kumar Brijesh , Shukla Anirudh 
Published: October 2019

<p class="abstract"><strong>Background:</strong> Cancer of head and neck are the 6<sup>th</sup> most common cancer worldwide, with an increasing frequency in developing countries. In India head and neck cancers account for 30-40% cancer at all sites. Head and neck cancers are one of the major causes of morbidity and mortality in older age groups. The lack of awareness, unavailability of proper screening facilities in rural population and use of carcinogenic addiction are the cause for high prevalence of cancer of head and neck in developing countries.</p><p class="abstract"><strong>Methods:</strong> This cross-sectional study on head and neck carcinoma and its association with environmental factors was carried out in the Department of Otorhinolaryngology and Head- Neck surgery, N. S. C. B. MCH, Jabalpur from January 2016 to January 2017. </p><p class="abstract"><strong>Results:</strong> The prevalence is found to be significantly high in carcinoma oral cavity which is 45.5% followed by carcinoma larynx (30%). These are affecting male more than female with ratio of 6:1, in the age group of 4<sup>th</sup> to 6<sup>th</sup> decade, living in low socioeconomic strata. Majority are associated with tobacco chewing (33.3%) followed by smoking (25.5%).</p><p class="abstract"><strong>Conclusions:</strong> It is concluded that patients usually present to a tertiary care centre at advanced stages. This can be attributed to lack of awareness and unavailability of proper medical facilities in rural population. There should be awareness about disease, health education in community about carcinogenic substances like tobacco, smoking, alcohol etc., proper medical facilities in low socioeconomic strata to reduce the burden of carcinomas.</p><p> </p>
Clinical profile of patients with deep neck space infections: a review of 62 patients from a tertiary care hospital of North India
Authors: Verma Rohit , Angral Sumeet , Singh Udeyana 
Published: October 2019

<p class="abstract"><strong>Background:</strong> Deep neck space infection (DNSI) is the infection of the potential spaces in the neck, specifically around the facial planes. Management of DNSI is traditionally by prompt surgical drainage of the abscess followed by antibiotics. In select cases, nonsurgical treatment using appropriate antibiotics may be employed. The objective of this study was to review the clinical profile of patients with DNSI.</p><p class="abstract"><strong>Methods:</strong> This was a retrospective chart review of 62 patients of DNSI managed at a tertiary care hospital of North India. Various parameters assessed in study included the demographical profile of the patients, symptomatology, possible aetiology, site distribution, bacteriology, the co-morbid conditions and treatment received. </p><p class="abstract"><strong>Results:</strong> Male preponderance was seen in this study with male:female ratio of 1.69:1. Swelling was the main complaint in majority of the patients (91.9%, 57 of 62 patients). The most common aetiology was odontogenic infection. Diabetes mellitus was seen in 25.8% (n=16) patients. Multiple space involvement was seen in majority of the patients with submandibular space being the most commonly involved site (43.5%). Most patients had negative pus cultures. The most common organism isolated was <em>Staphylococcus aureus</em>. All patients underwent surgical drainage.</p><p class="abstract"><strong>Conclusions:</strong> Odontogenic pathology is the most common cause related to DNSI. So extreme caution should be exercised by dentists in diabetic patients and in those with other immunocompromised status. Pus culture should be obtained before the start of antimicrobial therapy. If not diagnosed and treated in time, DNSI can turn out to be fatal.</p>
Cervical lymphadenopathy as initial presentation of genito-urinary cancer
Authors: Barua Sasanka K. , Pratihar Sarbartha K. , Kaman Pranab K. , Garg Atul , T. P. Rajeev , Baruah Saumar J. , Bagchi Puskal K. , Sarma Debanga , Phukan Mandeep 
Published: October 2019

<p class="abstract">Head and neck cancers rank fifth amongst the most affected cancers in the world. Metastasis to cervical lymph nodes is primarily from sites in head and neck. About 1% of all malignant cervical adenopathies are encountered as metastasis from remote primary site. We present here our experience of four cases in last five years. Patients presented as cervical lymphadenopathy with unknown primary, which on evaluation was found to be of genitourinary source from different sites. It is a single centre retrospective study. We reviewed cancer registry. We found four cases of genitourinary cancer with cervical lymph node metastasis. Patients presented as cervical lymphadenopathy of unknown primary. Among those one papillary renal cell cancer with rhabdoid differentiation, one testicular cancer, two prostate cancer. One case was a 67 year male patient, who revealed papillary renal cell carcinoma with rhabdoid features. Another patient was a male of 31 years, who had left testicular mass with retroperitoneal and cervical lymphadenopathy. Two patients of 68 year and 74 year respectively had metastatic prostate cancer. All patients underwent proper treatment and regularly followed up. Although rare, malignant cervical lymphadenopathy may be the first clinical manifestation of metastasis from genitourinary tumors. Evaluation of genitourinary system must be included in the protocol for uncovering the primary tumor site in cases of isolated cervical adenopathy.</p><p class="abstract"> </p>
Income Levels and Factors That Influence the Unsustainability of Cassava (Manihot Utilissima) Partnership in Lampung Province, Indonesia
Authors: Zakaria Wan Abbas , Endaryanto Teguh , Mas Indah Lidya Sari , Marlina Lina , Mutolib Abdul 
Published: October 2019

Lampung Province is the largest cassava center in Indonesia. The cassava partnership pattern developed in Lampung as an effort by companies and farmers to increase production and obtain optimal benefits for each party. Unfortunately, many partnerships failed and eventually ended in the middle. This study aims to analyze the income of partner cassava farmers and non-partner cassava farmers and the factors leading to cease of the cassava partnership in Lampung Province, Indonesia. This study was conducted using a survey method in the central locations of cassava production and tapioca agroindustry centers in Lampung Province from July to September 2018. The number of sample farmers was 126 cassava farmers (63 farmers conducted partnerships and 63 farmers had not been in partnership). Data were analyzed by descriptive quantitative method. Analysis of the factors that influence farmers’ decisions to do partnership was assessed using logistic regression. Research of cash income of partner cassava farmers was Rp 22,855,464.79 per ha and cash income of non-partner cassava farmers was Rp 13,819,044.20. The factors that influence the decision of cassava farmers in partnerships were land area, cassava farming experience, and farming income. Although promising, many partnership patterns of agricultural products, particularly cassava in Lampung, have discontinued (break-off partnerships). The unsustainability of cassava partnership in Lampung was caused by the violations committed by farmers by selling their crops to other companies/factories and then the companies/factories paid cheaper price compared to other companies/factories that did not have partnerships with farmers.
Jorge Prelorán: las voces que aún podemos escuchar
Authors: Acosta Lucía 
Published: October 2019

En la poética del cineasta argentino Jorge Prelorán las motivaciones éticas y estéticas están estrechamente vinculadas. El presente artículo ubica su filmografía en el contexto del documental etnográfico, para destacar sus rupturas y continuidades respecto a otros realizadores nacionales e internacionales. A su vez, la circulación de la obra del director permite descubrir el potencial semántico que le confiere vigencia en la actualidad.
Por último, la dimensión ética y comprometida del trabajo fílmico de Prelorán se pone de manifiesto al señalar puntos de contacto entre sus etno biografías y los conceptos de: sujeto político, subjetivación, identificación y desidentificación de Jacques Rancière.
Development and validation of a prediction model for six-month societal costs in older community care-recipients in multiple countries; the IBenC study
Authors: Lier Lisanne van , Bosmans Judith E , Roest Henriette G van der , Heymans Martyn W , Garms-Homolová Vjenka , Declercq Anja , Jónsson Pálmi V , Hout Hein P.J. van 
Published: October 2019

Abstract
Objectives To develop and validate a prediction model of societal costs during a period of six-month in older community care-recipients across multiple European countries. Methods Data from the IBenC study were used. Participants were older community care-recipients from five European countries. The outcome measure was mean six-months total societal costs of resource utilisation (healthcare and informal care). Potential predictors were assessed at baseline and included sociodemographic characteristics, functional limitations, clinical conditions, and diseases/disorders. The model was developed by performing Linear Mixed Models with a random intercept for the effect of country and validated by an internal-external validation procedure. Calibration curves and expected-to-observed (E/O) ratios were calculated. Results Living alone, caregiver distress, ADL and iADL impairment, required level of care support, health instability, presence of pain, behavioural problems, urinary incontinence, and multimorbidity significantly predicted societal costs during six months. The model explained 32% of the variation within societal costs and showed good calibration in Iceland, Finland and Germany. Minor model adaptations improved model performance in The Netherland and Italy. Conclusion The results can provide a valuable orientation for policymakers to better understand cost development among older community care-recipients. Of the predictors that were identified, caregiver distress, ADL and IADL impairment, health instability, presence of pain, behavioural problems, and urinary incontinence may be modifiable to some extent and could be targeted by interventions with the aim to reduce costs. The other, non-modifiable predictors, including living alone, required level of care support, and multimorbidity may be used by policy makers for optimal resource allocation.
Comparing intraoperative transesophageal and postoperative transthoracic echocardiography findings in mitral valve surgery: what changes?
Authors: Alves Patrícia Marques , Branco Carlos , Marinho Ana Vera , Ramalho Ana Rita Rita , Maldonado Maria João João , Coutinho Gonçalo , Prieto David , Gonçalves Lino , Antunes Pedro 
Published: October 2019

Abstract
OBJECTIVES Intraoperative transesophageal echocardiography (iTEE) has an important role in diagnosing the results of mitral valve (MV) replacement and repair. However, intraoperative Doppler features may be dissimilar from those measured at the postoperative follow-up period due to hemodynamic variations. There are no studies regarding MV surgery and comparisons between iTTE and postoperative transthoracic echocardiography (post-TTE). We aimed to evaluate the Doppler flow profiles observed in iTEE after MV replacement and repair and compare them with those observed in post-TTE.METHODS We conducted an observational study of 76 patients who underwent MV surgery (replacement or repair) over a 10-month period. iTEE was performed with Doppler evaluation (mean pressure gradient [MPG] and functional area). Patients were re-evaluated with TTE 72 hours after surgery (post-TTE). iTEE and post-TTE Doppler values were then compared and correlated.RESULTS The patients’ mean age was 59 ± 18 years and 55% were women. The prevalence of severe mitral regurgitation and severe mitral stenosis was 77.6% and 22.4%, respectively. MV repair was performed in 71% of cases. iTEE Doppler parameters correlated with post-TTE parameters, with minimal differences, specially in the MV repair group. The postoperative MPG was +0.4 ± 1 mmHg higher in the MV repair group and +1.0 ± 1.8 mmHg in the MV replacement group. There was global improvement in terms of systolic pulmonary artery pressure, although left ventricular ejection fractions were slightly reduced during the postoperative evaluation.CONCLUSIONS Our study demonstrates the usefulness of iTEE and its importance in establishing possible reference values for postoperative follow-ups.
Identification for prognostic value of differentially expressed genes in immune microenvironment of clear cell renal cell carcinoma
Authors: Zhang Xingming , Yin Xiaoxue , Liu Zhenhua , Sun Guangxi , Zhu Xudong , Zhang Haoran , Zhu Sha , Zhao Jinge , Chen Junru , Chen Ni , Shen Pengfei , Wang Jia , Zeng Hao 
Published: October 2019

Abstract
Background: Genes related to Anchorimmune microenvironment of clear cell renal cell carcinoma (ccRCC) remains unclear. We aimed to identify related to immune microenvironment and to screen the most significant genes to predict outcomes of ccRCC. Methods: Gene expression and clinicopathological data from TCGA data portal were obtained (KIRC). Immune and stromal scores were calculated based on ESTIMATE algorithm. DEGs between low and high groups of immune scores were identified. Subsequent functional enrichment analysis and protein-protein interaction of DEGs were conducted by DAVID database. Results: Patients were divided into low and high groups by medians according to immune (median: 1038.45) and stromal scores (median: 667.945), respectively. Immune scores were significantly correlated with clinicopathological parameters and overall survival (OS). Based on immune scores, 1433 genes were up-regulated, and among them, 890 DEGs were significantly associated with OS. Based on top 10 DEGs, cases with number of up-regulated genes ≥5 were associated poor OS (P = 0.002). In addition, the mean differences of percentages of CD8 T cells (11.32%), CD4 memory resting T cells (-4.52%) and mast resting cells (-3.55%) between low and high immune scores were the most significant. Conclusions: A list of immune microenvironment-related genes in ccRCC was initially identified, and high immune score was an independent poor prognostic factor of OS. Furthermore, the combination of these genes might use to predict the efficacy of immunotherapy. Further analyses of these genes were warrant to explore their potential association with the prognosis of ccRCC.
Determining Factors Affecting The Medical Interns’ Choice Of Specialties Among Governmental Universities In Riyadh
Authors: Swaidan Ahmad Tariq Al , Luhidan Lama Abdullah Al , Albarrak Khaled Abdullah , Mubrick Rehab Abdullah Al , Suwaidan Hessah Ibrahim Al , Alshammari Rawan Abdulaziz , Barakeh Rima MHD Belal , Al-Ghusoon Moath Khalid , Alruwaily Bander Munir , alshammari sulaiman A 
Published: October 2019

Abstract
The nature of experience during the medical study at university may play an essential role in choosing the specialty. Objectives: to determine the effect of goveremtnal universities in general and on medical interns' career choice , taking into consideration the gender difference. Furthermore, to find out when governmental universities educate their students about the different specialties. Method: It was a cross-sectional study approved in July in 2018 that included 234 Saudi medical intern students from four different medical collages in governmental universities in Riyadh. These were King Saud University (KSU), Princess Norah University (PNU), Imam University (IU), and King Saud bin Abdulaziz for Health and Science (KSAU-HS) with consideration of gender differences and availability. All participants who are selected randomly completed an online-questioner. Result: Around two thirds (66%) of the participants ensure that their governmental universities had a positive influence in choosing the specialties dividing equally between both genders. According to the participants’ perceptions, all the items of the medical education system did not affect in choosing the specialty except three of them that have a positive effect which are elective experience (43.59%), clinical year (40.6%) and the personality of instructor (38.46%). Furthermore, one-third (33%) of the participants ensure that they are educated about the specialties in the third year. The most common positive factor is elective experience by 19.36%, while the most common negative factors are improper block duration and the personality of the instructor by 14.52%. Conclusion : Most governmental universities have a positive effect on their students' career choice, and they educate pre-graduate students about specialties.
A Novel FOXL2 Missense Mutation, c.1068G&gt;C, In Chinese Families with Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Type II
Authors: Wang Shaoyun , He Fanglin , Jia Ruobing , Ge Shengfang , Song Xin , Jia Renbing 
Published: October 2019

Abstract
Background Blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) is a hereditary disease caused by a mutation in the forkhead box L2 ( FOXL2 ) gene. Female patients suffering from premature ovarian failure (POF) were classified as type I, and others were classified as type II. We aimed to clarify a novel FOXL2 indel mutation in Chinese families and to predict the POF risk in the affected patient.Methods Three generations of one Chinese family with BPES were enrolled in this study. Blood samples from patients of this family were collected and then analysed by whole-exome sequencing. Confocal microscopy was performed to observe the subcellular location. Transactivation studies were performed with real-time PCR.Results This novel mutation (c.1068G>C) is located in the downstream of DNA-binding forkhead(FHD) domain, and the mutant protein could also exhibit transactivation capacity of StAR , a key regulator of POF. Conclusively, we discovered a novel FOXL2 mutation and predicted that female patient in this family should be classified as type II BPES.Conclusions Our study revealed a novel missense mutation (c.1068G>C) and expanded the spectrum of FOXL2 gene mutations. Although we were not able to determine the classification from clinical manifestation, we discovered the patient developed type II BPES through subcellular distribution and transactivation analysis.
The Epidemiology Of Primary Head And Neck Cancer In Black Lion Specialized Hospital Oncology Center, Ethiopia: A Hospital Based Retrospective Study
Authors: Tefera Amare Teshome , Bekele Biruk Girma , Dejene Demerew , Workicho Abdulhalik , Tigeneh Wondemagegnhu 
Published: October 2019

Abstract
Background Unfortunately, despite an increase in medical knowledge, the treatment need of head and neck cancers (HNCs) have not been improved in Ethiopia. In addition, there is no published evidence in the epidemiology of head and neck cancer patients in the country. The present study aimed to describe the prevalence and pattern of HNCs among patients seen at Black Lion Hospital oncology center.
Preoperative lymphocyte to monocyte ratio and prognostic nutritional index were correlated with clinical outcomes in patients with operable colon cancer
Authors: li zhigui , Ni Tiangen , Zhou Yong , Wu Xiaoting 
Published: October 2019

Abstract
Background: Systemic inflammation plays an important part in tumorigenesis and progression. The predictive values of the preoperative lymphocyte to monocyte ratio (LMR) and prognostic nutritional index (PNI) in colon cancer remained unclear. Methods: A total of 308 patients with colon cancer undergoing radical resection were enrolled and analyzed. The receiver operating curves were applied to identify the thresholds for these biomarkers. Kaplan-Meier method and multivariate analysis were used to identify independent prognostic factors. Results: The univariate analysis showed that elevated LMR and PNI were significantly correlated with better overall survival and progression-free survival. The multivariate analysis showed that LMR and PNI were the independent prognostic factors for overall survival. Conclusions: Preoperative LMR and PNI could serve as useful prognostic factor in patients with colon cancer undergoing radical resection.