bluuebunny/crossref_metadata_2025_split huggingface dataset:
Probing the Reorganization of Ionic Liquids’ Structure Induced by CO2 Sorption
Authors: Lepre Luiz Fernando , Costa Gomes Margarida , Ando Rômulo Augusto 
Published: April 2020

AbstractThe sorption of CO2 is often used to modify the macroscopic properties of liquids and solids. In the particular case of ionic liquids, different from molecular liquids, the sorption of CO2 may not induce volume expansions due to the strong Coulombic interactions between the ions of the fluid. However, a considerable viscosity decrease has been systematically observed. In order to understand the mechanisms of properties modifications in ionic fluids, herein we used Raman spectroscopy to probe the effect of CO2 on the structure of ionic liquids. It is shown that CO2 perturbs the electrostatic interactions between cations and anions, thus inducing a change in the polar domain of ionic liquids. It is observed that ionic liquids having bulkier ions are more prone to be perturbed by CO2 in comparison to ionic liquids having smaller ions. These results reveal new means of controlling the electrostatic forces between the ions and contributes to the mechanistic understanding of the modification of the macroscopic properties of ionic liquids by CO2 sorption.
Validated Voltammetric Method for the Simultaneous Determination of Anti‐diabetic Drugs, Linagliptin and Empagliflozin in Bulk, Pharmaceutical Dosage Forms and Biological Fluids
Authors: Rizk Mohamed , Attia Ali K. , Mohamed Heba Y. , Elshahed Mona S. 
Published: April 2020

AbstractA cobalt oxide nanoparticles (Co3O4NPs) and multi walled carbon nanotubes (MWCNTs) modified carbon paste electrodes were used to study the electrochemical behavior of linagliptin and empagliflozin in Britton Robinson buffer solution of pH 8.0 using cyclic and square wave voltammetry. The above mentioned modified electrodes showed highly sensitive sensing and gave an excellent anodic response for both drugs. The peak current varied linearly over the concentration ranges: 3.98×10−5–1.53×10−3 mol L−1(18.82–723.00 μg/mL) and 7.94×10−6–1.07×10−4 mol L−1(3.65–48.25 μg/mL) with determination coefficients of 0.9999 and 0.9998 for linagliptin and empagliflozin, respectively. The recoveries and relative standard deviations were found in the following ranges: 98.80 %–102.00 % and 0.23 %–1.90 % for linagliptin and 98.30 %–101.80 % and 0.11 %–1.86 % for empagliflozin. The detection and quantification limits were 1.13×10−5and 3.76×10−5 mol L−1(5.34and17.77 μg/mL) for linagliptin, 1.71×10−6and 5.68×10−6 mol L−1(0.77 and 2.56 μg/mL) for empagliflozin. The proposed sensors have been successfully applied for the determination of the drugs in bulk, pharmaceutical formulations and biological fluids.
Ceftriaxone‐induced radiation recall dermatitis
Authors: Patel Nirav V. , Samuels Michael , Elsayyad Nagy 
Published: April 2020

AbstractBackgroundRadiation recall dermatitis (RRD) is an acute inflammatory skin reaction occurring in a skin area previously exposed to radiotherapy and triggered by subsequent intake of a drug, most commonly a chemotherapeutic agent. RRD secondary to antibiotics has also been reported but is a rare phenomenon overall and there are no reports of RRD in association with ceftriaxone exposure.MethodsWe report on a 59‐year‐old patient who had received radiotherapy to the neck bilaterally and who developed RRD 6 months later after a single dose of intramuscular ceftriaxone.ResultsThe patient's rash resolved without further intervention over the ensuing 2 days following administration of a single dose of ceftriaxone.ConclusionThis case illustrates that while RRD secondary to antibiotic exposure is rare, it is part of the differential diagnosis to be considered for acute dermatitis when there is a past history of radiotherapy to the same skin area.
Risk factors for progression to blast phase and outcome in 589 patients with myelofibrosis treated with ruxolitinib: Real‐world data
Authors: Palandri Francesca , Breccia Massimo , Tiribelli Mario , Bonifacio Massimiliano , Benevolo Giulia , Iurlo Alessandra , Elli Elena M. , Binotto Gianni , Tieghi Alessia , Polverelli Nicola , Martino Bruno , Abruzzese Elisabetta , Bergamaschi Micaela , Heidel Florian H. , Cavazzini Francesco , Crugnola Monica , Bosi Costanza , Isidori Alessandro , Auteri Giuseppe , Forte Dorian , Latagliata Roberto , Griguolo Davide , Cattaneo Daniele , Trawinska Malgorzata , Bartoletti Daniela , Krampera Mauro , Semenzato Gianpietro , Lemoli Roberto M. , Cuneo Antonio , Di Raimondo Francesco , Vianelli Nicola , Cavo Michele , Palumbo Giuseppe A. 
Published: April 2020

AbstractThe impact of ruxolitinib therapy on evolution to blast phase (BP) in patients with myelofibrosis (MF) is still uncertain. In 589 MF patients treated with ruxolitinib, we investigated incidence and risk factors for BP and we described outcome according to disease characteristics and treatment strategy. After a median follow‐up from ruxolitinib start of 3 years (range 0.1‐7.6), 65 (11%) patients transformed to BP during (93.8%) or after treatment. BP incidence rate was 3.7 per 100 patient‐years, comparably in primary and secondary MF (PMF/SMF) but significantly lower in intermediate‐1 risk patients (2.3 vs 5.6 per 100 patient‐years in intermediate‐2/high‐risk patients, P < .001). In PMF and SMF cohorts, previous interferon therapy seemed to correlate with a lower probability of BP (HR 0.13, P = .001 and HR 0.22, P = .02, respectively). In SMF, also platelet count <150 × 109/l (HR 2.4, P = .03) and peripheral blasts ≥3% (HR 3.3, P = .004) were significantly associated with higher risk of BP. High‐risk category according to dynamic International Prognostic Score System (DIPSS) and myelofibrosis secondary to PV and ET Collaboration Prognostic Model (MYSEC‐PM predicted BP in patients with PMF and SMF, respectively. Median survival after BP was 0.2 (95% CI: 0.1‐0.3) years. Therapy for BP included hypomethylating agents (12.3%), induction chemotherapy (9.2%), allogeneic transplant (6.2%) or supportive care (72.3%). Patients treated with supportive therapy had a median survival of 6 weeks, while 73% of the few transplanted patients were alive at a median follow‐up of 2 years. Progression to BP occurs in a significant fraction of ruxolitinib‐treated patients and is associated with DIPSS and MYSEC‐PM risk in PMF and SMF, respectively.
Radiological findings and clinical characteristics of pregnant women with COVID‐19 pneumonia
Authors: Wu Xiaoqing , Sun Ruihong , Chen Jianpu , Xie Yuanliang , Zhang Shutong , Wang Xiang 
Published: April 2020

AbstractObjectiveTo study chest CT images and clinical characteristics of COVID‐19 pneumonia in pregnant patients to examine any correlation.MethodsBetween December 31, 2019 and March 7, 2020, 23 hospitalized pregnant patients with confirmed COVID‐19 were enrolled in the study. Clinical presentations were collected retrospectively from records, including laboratory testing, chest CT imaging, and symptoms. Descriptive analysis and correlation of patients’ clinical and CT characteristics were performed. Laboratory results from time of first admission and CT absorption (defined as reduction in lesion area, decrease in density, and absorption of some solid components) were compared between symptomatic and asymptomatic patients.ResultsFifteen (65.2%) patients were asymptomatic with patchy ground‐glass opacity in a single lung lobe. Eight (34.8%) patients were symptomatic with multiple patchy ground‐glass shadows, consolidation, and fibrous stripes. Differences in lymphocyte percentage and neutrophil granulocyte rate between first admission and CT absorption were significant (P<0.001). Median absorption time was shorter in the asymptomatic group compared with the symptomatic group (5 vs 10 days; P<0.001). Median hospitalization time between asymptomatic and symptomatic patients was 14 vs 25.5 days; P>0.001. Median absorption time and length of hospitalization for all patients was 6 days (IQR 5–8) and 17 days (IQR 13–25), respectively.ConclusionRadiological findings and clinical characteristics in pregnant women with COVID‐19 were similar to those of non‐pregnant women with COVID‐19. Median absorption time and length of hospitalization in asymptomatic patients were significantly shorter than in symptomatic patients. Lymphocyte percentage and neutrophil granulocyte rate may be used as laboratory indicators of CT absorption.
Ocean Swimmer, Woodchopper, Road Tripper: Using Metaphor to Develop Students’ Identities as Writers
Authors: Perrow Margaret , Feldstein Mary (Lauren) , Sieler Arlene 
Published: April 2020

AbstractStudents who understand their writing process and see themselves as writers are more likely to successfully tackle unfamiliar genres and writing tasks. In this self‐study, a college English professor and two first‐year college students make a case for an extended‐metaphor assignment that helps students build stronger identities as writers. Metaphor plays a critical role in our understanding of the world and, hence, has high pedagogical value. By giving students a familiar framework with which to analyze their (less familiar) writing process, the metaphor essay develops students’ identities as academic writers, in turn helping them think more strategically about future writing tasks. Excerpts from each author’s own metaphor essay are interwoven with reflections on how the extended‐metaphor essay assignment scaffolded their awareness of the writing process and supported their development as writers. Comments from students suggest that they drew strategically on their extended metaphor in subsequent writing tasks.
Study on the optical and biological properties in vitro of IR808‐PEG‐FA
Authors: Wang Sujun , Tang Qianqian , Ya Huiyuan , Fan Yanli , Feng Wenjing , Du Jie , Fang Shengtao , Shi Chunmeng 
Published: April 2020

AbstractIR808, an IR780 derivative, is capable of fluorescently imaging and photodynamic therapy in vitro and in vivo. However, its application is greatly hampered by hydrophobicity, toxicity and nonspecific delivery to the targeting tissue and that causes accumulation in the liver and kidney. In order to overcome these limitations, we prepared IR808‐PEG‐FA from IR808, amino‐terminated poly(ethylene glycol) (NH2‐PEG‐NH2, denoted as PEG) and folate (FA). PEG, an accepted hydrophilic medicinal agent, was introduced to improve hydrophobicity, and FA was used to increase targeting ability of the conjugate. The obtained product provides a good water solubility and stronger light intensity in near infrared (NIR)‐imaging, and CCK‐8 test demonstrated which had no appreciable toxicity. In addition, the cell uptake results indicated that IR808‐PEG‐FA was specifically targeted to positive tumors cells with folate receptor (FR) compared with IR808, and thus it may be used as a novel diagnostic agent or imaging‐guided agent for cancer treatment. So this article provides a way to improve hydrophobicity, optical stability and targeting ability in the field of nano‐probe for fluorochromes.
Developing and testing a readiness tool for interpersonal violence prevention partnerships with community‐based projects
Authors: Andrews Naomi C. Z. , Motz Mary , Pepler Debra J. 
Published: April 2020

AbstractCommunity‐based projects that serve vulnerable families have the opportunity to identify and respond to interpersonal violence (IPV). We developed a readiness assessment tool to support selection of projects to participate in an initiative that involved implementing a community‐based IPV intervention for mothers. The overarching aim of the current study was to describe the development of this tool and examine the reliability of coding, validity, and utility of the tool. After developing and refining the tool, 41 community‐based projects completed the tool. Responses were coded and scored; scores were used to select projects for the initiative. Preliminary validation for the tool included (a) expert opinion, (b) uptake/implementation of the intervention, and (c) feedback and responses from service providers in terms of the usefulness and importance of the tool. This tool can be used by both researchers and service providers to assess community project readiness and capacity to provide trauma‐informed services for vulnerable families.
ATP6AP1‐CDG: Follow‐up and female phenotype
Authors: Lipiński Patryk , Rokicki Dariusz , Bogdańska Anna , Lesiak Justyna , Lefeber Dirk J. , Tylki‐Szymańska Anna 
Published: April 2020

AbstractIn 2016, 11 male patients were reported with immunodeficiency and hepatic, gastric and (in some) neurological disease due to X‐linked ATP6AP1 deficiency (ATP6AP1‐CDG). In 2018, three other patients were reported with additional features: connective tissue abnormalities, sensorineural hearing loss, hyperopia, glomerular and tubular dysfunction, exocrine pancreatic insufficiency and altered amino acid and lipid metabolism. We here present a follow‐up of three reported siblings showing progression of deafness to total hearing loss, progressive loss of hair up to alopecia, chestnut skin and, at last follow‐up, in some of them proteinuria. Three female carriers showed a normal serum transferrin isoelectrofocusing but in two of them there was a persistent proteinuria.
Groundwater‐controlled phosphorus release and transport from sandy aquifer into lake
Authors: Kazmierczak Jolanta , Postma Dieke , Müller Sascha , Jessen Søren , Nilsson Bertel , Czekaj Joanna , Engesgaard Peter 
Published: April 2020

AbstractAwareness of groundwater‐borne dissolved inorganic phosphorus (DIP) loadings into lakes and its role in lake eutrophication is increasing, albeit DIP of natural origin is often ignored. Release of geogenic DIP from an adjacent aquifer and its transport with groundwater into a eutrophic lake is described by combining hydrogeochemical data collected in this study (sampling of piezometers, hydrogeochemical profiles, and seepage meters) with groundwater flow and discharge rates from earlier studies. The major part of the DIP that entered the lake with discharging groundwater was mobilized from iron hydroxides reduced by organic matter buried in the sediments of the old lake bottom. This is indicated by the correlation between DIP and ferrous iron (Fe2+) concentrations, with a DIP/Fe2+ molar ratio of 0.06, and an increase in pH. One‐dimensional reactive transport modeling indicated that high discharge rates (> 0.1 m d−1) of anoxic groundwater upwelling in areas adjacent to the lakeshore prevent downward diffusion of oxygen into the aquifer and do not leave enough time for DIP to become rebounding to the mineral phases at the sediment‐water interface. The groundwater‐controlled DIP input into the lake calculated along a two‐dimensional cross‐section averaged 0.01 mol DIP m−2 yr−1. A 2 m wide offshore high discharge zone delivered approximately 13% of the DIP into the lake. The continuous, external loading of geogenic DIP sustains lake eutrophication and explains the failure of two previous lake restoration attempts.
Nutrient enrichment offsets the effects of low light on growth of the kelp Ecklonia radiata
Authors: Blain Caitlin O. , Shears Nick T. 
Published: April 2020

AbstractIncreased input of terrigenous matter and pollution into coastal marine ecosystems results in both a decline in benthic irradiance and an influx of nutrients. Though low light conditions have been demonstrated to have adverse effects on benthic primary producers, associated increases in nutrients may alleviate some of this stress by enhancing growth and productivity. We examined the interactive effect of low light and increased nitrogen (N) availability on the growth and physiological response of the kelp Ecklonia radiata using field and mesocosm experiments. Nutrient enrichment had positive effects on the growth of E. radiata in both experiments regardless of light treatment, though increases were c. 50% higher at low light. In contrast, the ability of E. radiata to acclimate to low light and net primary production (NPP) was not affected by nutrient addition, but NPP was over 2 times greater in high light treatments than low light treatments. In low light conditions, E. radiata allocated a higher proportion of assimilated C to growth compared to those in high light conditions and this was accentuated with N‐enrichment. These results indicate that growth, rather than photosynthesis, in E. radiata is limited by N availability and may also indicate a low light coping strategy whereby E. radiata invest more energy into the development of photosynthetically active tissues in order to increase photosynthetic potential. Thus, nutrient enrichment associated with increased turbidity may alleviate some of the stresses associated with living under low light and facilitate the persistence of E. radiata in turbid environments.
A Robust Carbon Nanotube and PVDF‐HFP Nanofiber Composite Superwettability Membrane for High‐Efficiency Emulsion Separation
Authors: Wang Yaqiong , Yue Guichu , Li Dianming , Hou Lanlan , Zhao Xiaochen , Cui Zhimin , Bai Jie , Wang Nü , Zhao Yong 
Published: April 2020

AbstractOil or chemical purification is significant not only for industrial safety production but also because it conforms to the principle of sustainable development. In this paper, based on the synergistic concept of superwettability and nanopores sieve effect, a superoleophilic and under‐oil superhydrophobic carbon nanotube/poly(vinylidene fluoride‐co‐hexafluoropropylene) nanofiber composite membrane is prepared via electrospinning, pressure‐driven filtration, and chemical vapor modification. The as‐prepared membrane with durable mechanical and chemical stabilities achieves separation efficiency higher than 99.9% and high flux up to 632.5 L m−2 h−1 bar−1 for different water‐in‐oil emulsions. This membrane is highly promising for the petroleum and chemical industries for both product quality improvement and green recycling manufacturing processes.
Exploring a broader context of the home environment and its relationship with asthma control in American Indian children
Authors: Brooks Jada L. , Asafu‐Adjei Josephine , Currin Emily G. , Beeber Linda S. 
Published: April 2020

AbstractIn this cross‐sectional study of 60 American Indian mother‐child dyads from Southeastern North Carolina, we examined whether childhood asthma control was related to household‐level factors, such as environmental tobacco smoke and family management behaviors. We also examined the relationships among family management behaviors and maternal depressive symptoms. We used logistic regression to assess the relationships among childhood asthma control, the presence of environmental tobacco smoke, and family management behaviors, specifically condition management ability (CMA) and condition management effort (CME). We used linear regression to evaluate the relationships between both CMA and CME and maternal depressive symptoms. Better asthma control in children was associated with the absence of environmental tobacco smoke in the home and the maternal perception of asthma as a manageable condition. Mothers perceived an increase in effort to manage their child's asthma as their depressive symptoms increased. These findings emphasize the importance of environmental triggers, perceptions of condition management, and maternal mental health in controlling asthma in American Indian children. Interventions to reduce environmental triggers, treat maternal depressive symptoms, and support mothers in their ability to manage childhood asthma may yield better asthma control and help to reduce existing racial disparities in this population.
Highly efficient alginate‐based macromolecular photoinitiator for crosslinking and toughening gelatin hydrogels
Authors: Huang Xing , Zhang Yuxi , Li Feng , Zhang Jun , Dai Yuhua , Shi Mengquan , Zhao Yuxia 
Published: April 2020

AbstractConstructing gelatin hydrogels through photopolymerization is getting increasingly attractive due to their excellent biocompatibility and unparalleled flexibility in fabricating complex structures. In this study, an alginate‐based macromolecular photoinitiator (Alg‐2959) is synthesized by grafting Irgacure2959, a widely used hydrophilic small molecular photoinitiator, onto the framework of alginate. The characterization of Alg‐2959 is carried out by 1H nuclear magnetic resonance (1HNMR), Fourier infrared spectroscopic (FTIR), Thermogravimetric analysis (TGA), and UV–Vis absorption spectrum. It is shown that Alg‐2959 can induce the polymerization of acrylate monomer poly(ethylene glycol) diacrylate (PEGDA400) and glycidyl methacrylate modified gelatin (Gel‐GM) with similar initiation efficiency as Irgacure2959. Compared with the pure hydrogels prepared using Irgacure2959, the hybrid hydrogels containing Alg‐2959 can be further crosslinked by Ca2+ to form the double‐network hydrogels, which exhibit enhanced toughness and elasticity. In addition, due to the introduction of alginate, the migration stability of Alg‐2959 in the hydrogel networks is significantly improved compared with Irgacure2959. These results indicate the great potential of Alg‐2959 in preparing biocompatible and resilient photopolymers.
Highly Selective Photoreduction of CO2 with Suppressing H2 Evolution by Plasmonic Au/CdSe–Cu2O Hierarchical Nanostructures under Visible Light
Authors: Wang Hongzhi , Rong Hongpan , Wang Dong , Li Xinyuan , Zhang Erhuan , Wan Xiaodong , Bai Bing , Xu Meng , Liu Jiajia , Liu Jia , Chen Wenxing , Zhang Jiatao 
Published: April 2020

AbstractHere, the photocatalytic CO2 reduction reaction (CO2RR) with the selectivity of carbon products up to 100% is realized by completely suppressing the H2 evolution reaction under visible light (λ > 420 nm) irradiation. To target this, plasmonic Au/CdSe dumbbell nanorods enhance light harvesting and produce a plasmon‐enhanced charge‐rich environment; peripheral Cu2O provides rich active sites for CO2 reduction and suppresses the hydrogen generation to improve the selectivity of carbon products. The middle CdSe serves as a bridge to transfer the photocharges. Based on synthesizing these Au/CdSe–Cu2O hierarchical nanostructures (HNSs), efficient photoinduced electron/hole (e−/h+) separation and 100% of CO selectivity can be realized. Also, the 2e−/2H+ products of CO can be further enhanced and hydrogenated to effectively complete 8e−/8H+ reduction of CO2 to methane (CH4), where a sufficient CO concentration and the proton provided by H2O reduction are indispensable. Under the optimum condition, the Au/CdSe–Cu2O HNSs display high photocatalytic activity and stability, where the stable gas generation rates are 254 and 123 µmol g−1 h−1 for CO and CH4 over a 60 h period.