bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immune profiling of gliomas reveals a connection with Tau function and the tumor vasculature.
Authors: Cejalvo Teresa , Gargini Ricardo , Segura-Collar Berta , Mata-Martínez Pablo , Herranz Beatriz , Cantero Diana , García-Pérez Daniel , Pérez-Núñez Ángel , Ramos Ana , Ruano Yolanda , Hernández-Laín Aurelio , Martín-Soberón Mari Cruz , Sánchez-Gómez Pilar , Manuel Sepúlveda Sánchez Juan 
Published: September 2020

Abstract
Background: Gliomas remain refractory to all attempted treatments, including those using immune checkpoint inhibitors. The characterization of the tumor (immune) microenvironment has been recognized as an important challenge to get a mechanistic explanation for this lack of response and to improve the therapy of glial tumors. Methods: We designed a prospective analysis of the immune cells of gliomas by flow cytometry. Tumors with or without isocytrate dehydrogenase 1/2 (IDH1/2) mutations were included in the study. The genetic profile and the presence of different molecular and cellular features of the gliomas were analyzed in parallel. The findings were validated in mouse glioma models.Results: We observed that few immune cells infiltrate mutant IDH1/2 gliomas and we distinguished two different profiles in their IDH1/2 wild-type counterparts. The first one has an important immune component, particularly enriched in myeloid cells with immunosuppressive features. The second group is more similar to mutant IDH1/2 gliomas, with few immune cells and a less immunosuppressive profile. Notably, we observed a direct correlation between the immune content and the presence of vascular alterations, which were associated with a reduced expression of Tau, a microtubule-binding-protein that controls the formation of tumor vessels in gliomas. Furthermore, overexpression of Tau was able to reduce the immune content in orthotopic mouse glioma models, delaying tumor growth. Conclusions: Our results confirmed the reduced infiltration of immune cells in IDH1/2 mutant gliomas. Moreover, we have found that the immunological content distinguishes two groups of IDH1/2 wild-type gliomas, one highly enriched in immunosuppressive cells and one with few lymphocytes and myeloid cells. Our data indicated a direct correlation between the presence of vascular alterations and the entrance of leukocytes in gliomas. Interestingly, high levels of Tau inversely correlated with the vascular and the immune content of gliomas. Altogether, our results could be exploited for the design of more successful clinical trials with immunomodulatory molecules.
Dysbiotic microbiota to complement TNM staging or HPV status for prognostic indication of head and neck cancer
Authors: Dou Yu , Ma Chao , Wang Ketao , Liu Shaohua , Sun Jintang , Tan Wanye , Neckenig Markus , Wang Qingjie , Dong Zuoqing , Gao Wenjuan , Chen Anwei , Zhang Dong , Wang Bing , Shi Liang , Nan Zhaodi , Ai Dan , Yu Wenjie , Liu Jia , Song Bingfeng , Zhao Lei , Shao Qianqian , Zhu Yong , Wang Tao , Wang Jianing , Wu Xunwei , Hu Wei , Wei Fengcai , Xu Xin , Qu Xun 
Published: September 2020

Abstract
Background: Microbiota has been found associated with the incidence of head and neck cancers (HNCs), however, the association of microbiota with the prognosis of HNCs remains unknown. In the present study, the relationship between tumoral microbiata and survival was examined. The prognosis predictive value of tumoral microbiota to complement classic TNM staging and Human Papillomavirus (HPV) status was also investigated.Results: We conducted a retrospective study including 158 primary tumors using 16S rRNA sequencing. The tumoral microbiota in the HNC patients with poor prognosis were significantly different from that of the patients with good prognosis. A greater abundance of Schlegelella or Methyloversatilis was characterized in HNC patients with poor prognosis and a greater abundance of Lactobacillus or Bacillus was characterized in HNC patients with good prognosis. Strikingly, the microbial dysbiosis index (MDI), the ratio of above poor and good prognosis associated genera, was strongly associated with overall survival [hazard ratio (HR) 3.24; 95% confidence interval (CI), 1.88 to 5.59; P < 0.001] and disease free survival (HR 2.11; 95% CI, 1.34 to 3.34; P = 0.001), independently of age, TNM staging, differentiation and HPV status. Intriguingly, the combination of the MDI and HPV status significantly improved the prognostic performance of HPV status (AUC of 0.719 and 0.581 respectively, P = 0.024). Moreover, the MDI showed higher risk for overall survival in the late stage patients (HR 3.35; 95% CI, 1.73 to 6.49; P < 0.001) compared with the early stage patients (HR 2.41; 95% CI, 1.00 to 5.84; P = 0.051). Conclusion: Together, the MDI could serve as an applicable indicator of the prognosis of HNCs, and complements the predictive values of TNM staging and HPV status. Moreover, the findings of the higher risk of the MDI in the late stage patients supply directions for future studies that microbial modulation might be valuable in survival improvement of HNCs, especially for the late stage patients.
Knowledge of dietary guidelines and portion sizes in Saudi Arabian mothers; cross-sectional study
Authors: Hakim Noor , Alsini Najlaa , Kutbi Hebah , Mosli Rana , Eid Noura , Mulla Zeinab 
Published: September 2020

Abstract
Background: it is known that knowledge of dietary guideline is linked to healthy eating habit. This study aims to investigate Saudi Mother’s knowledge of current dietary guidelines regarding food groups and portion sizes and to investigate its relation to the sociodemographic factors.Methods: This cross-sectional study using Nutrition Education Program to recruit 101 mother and child. Instructed on site- online survey were collected to measure the mother’s knowledge of dietary guideline and portion sizes. quantitative analysis using Chi-square and Kruksan-Wallis tests.Results: 29.1 % of the participants were aware of the MyPlate guidelines and 51.5 % said that they affected by healthy plate choices. Being married was significantly associated with knowing about the MyPlate Image (P= 0.004). Correct identification of food groups on the MyPlate Image and correct identification of serving sizes of food group was less than 50% for most food groups. A significantly greater percentage of those with a postgraduate education were accurate about the correct servings of fruit, vegetables and grains (P=0.049).Conclusions: Nutrition knowledge of food groups and serving sizes was poor in the sample of Saudi women. This research provides evidence that nutrition education is needed in the Saudi Arabia and the finding are relevant for future health promotion strategies. The study has also identified sociodemographic groups that possibly may need to be targeted with more attention in future nutrition education programs such as those with low income, lower education level and unmarried women.
Resistive switching and optical properties of strontium ferrate titanate thin film prepared via chemical solution deposition
Authors: Li Jun , Tang Xingui , Liu Qiuxiang , Jiang Yanping , Tang Zhenxun 
Published: September 2020

Abstract
The polycrystalline strontium ferrate titanate (SrFe0.1Ti0.9O3, abbreviated to SFTO) thin films have been successfully prepared by chemical solution method. By analyzing the current-voltage (I-V) characteristics, we discuss the conduction mechanism of SFTO. It is found that the number of oxygen vacancy defects is increased by Fe ions doping, making SFTO be with better resistive switching property. Fe ions doping can also enhance the absorption of strontium titanate to be exposed to visible light, which is associated with the change of energy band. The band gap width (2.84 eV) of SFTO films is figured out, which is less than that of pure strontium titanate. Due to more oxygen vacancy defects caused by Fe ions doping, the band gap width of strontium titanate was reduced slightly. The defect types of SFTO thin films can be determined by electron paramagnetic resonance spectroscopy. In addition, we analyzed the energy band and state density of SFTO by first-principle calculation based on density functional theory, and found that Fe ions doping can reduce the band gap width of strontium titanate with micro-regulation on the band structure. A chemical state of SFTO was analyzed by X-ray photo electron spectroscopy. At the same time, the structure and morphology of SFTO were characterized by X-ray diffraction and scanning electron microscope. This study deepened the understanding of the influence of Fe ions doping on the structure and properties of strontium ferrate titanate, which is expected to be a functional thin film material for memristor devices.
Effect of chopped ZrO2 fiber content on the microstructure and properties of CaO-based integral ceramic mold
Authors: Yang Qiang , Wang Fu , Li Dichen 
Published: September 2020

Abstract

A chopped ZrO2 fiber (ZrO2 (f)) reinforced CaO-based integral ceramic mold was successfully fabricated by stereolithography (SLA) and tert-butyl alcohol (TBA)-based gel-casting, and the effect of chopped ZrO2 (f) content on properties of the ceramic mold was investigated. The results show that the ZrO2 (f) content had a significant effect on the viscosity of CaO-based ceramic slurry, which directly affects the filling ability of the ceramic slurry in complex structures of the integral mold. The tiny structures of the ceramic mold cannot be filled completely with a ZrO2 (f) content exceed 3 vol%. When the content of ZrO2 (f) was 3 vol%, the ceramic slurry could meet the requirement of gel-casting with a viscosity of 0.84 Pa·s. The ZrO2 (f) content played an important role in tailoring properties of the ceramic mold, the sample fabricated with 3 vol% fiber content showed a harmonious microstructure and exhibited an excellent comprehensive performance with a room temperature (25 ºC) bending strength of 22.88 MPa, the elevated temperature bending strength (1200 ºC) of 15.74 MPa, the elevated temperature (1200 ºC) deflection of 0.86 mm and the sintering shrinkage of 0.40%, which can meet the requirements of casting very well.
Examining the correlation between the weather conditions and COVID‐19 pandemic in India: A mathematical evidence
Authors: Borah Manash Jyoti , Hazarika Bipan , Panda Sumati Kumari , Nieto Juan Jose 
Published: September 2020

Abstract
There is a drastic increase for utilizing mathematical modeling in the study of epidemiology diseases. Mathematical models may predict how infectious diseases advance to demonstrate the possible result of an outbreak, and help support initiatives in public health. In the present situation, the 2019-nCoV terrifies the world. In this article, for the analysis of Covid-19 progression in India, we present new insights to formulate a data-driven epidemic model and approximation algorithm using the real data on infection, recovery and death cases with respect to weather in the view of mathematical variables.
Sero-prevalence of Hepatitis B virus infection and associated factors among pregnant women attending antenatal care service in health institutions in Gedeo Zone, Southern Ethiopia
Authors: Tadiwos Mhiret Belay , Kanno Girum Gebremeskel , Areba Abereham Shiferaw , Aregu Mekonnen Birhanie 
Published: September 2020

Abstract
Background: Hepatitis B virus infection is a major public health problem worldwide which is a major cause of morbidity and mortality. This study aimed to assess the prevalence of hepatitis B virus infection and associated factors among pregnant mothers in Gedio Zone, southern Ethiopia.Methods: Institutional based cross-sectional study was conducted in governmental and private health facilities in Gedeo zone from January to April 2019. The study participants were selected using stratified random sampling techniques. Eugene strip test was used to determine hepatitis B virus infection among pregnant mothers. The status of HIV was collected from the records. Other variables were collected from the mothers using interviewer administered questionnaires. Logistic regression was used for the analysis. Adjusted Odds Ratios and their 95% Confidence Interval were calculated to determine association between HBsAg Sero-positivity and various factors. A p-value less than 0.05 were considered as significant. The data was analyzed using the SPSS version 25 statistical software. Results: Prevalence of hepatitis B virus among pregnant mothers was 9.2% in Gedio Zone. Previous birth at health institution [AOR=4.4, 95% CI: 1.7, 11.2], blood transfusions [AOR=4.4, 95% CI: 1.8, 10.5], previous history of Hospital admission [AOR=3.3, 95% CI: 1.5, 7.5], ear piercing practice [AOR=5.7, 95% CI: 1.1, 29.0], current Gestational age [AOR=3.6, 95% CI: 1.2, 11.2], and HIV status of the mother [AOR=6.1, 95% CI: 1.3, 30.0] had statistical significant association with HBsAg Sero-positivity.Conclusions: Hepatitis B virus infection was found to have higher endemicity (9.2%) in the Gedio Zone. History of blood transfusion, hospital admissions, ear piercing, being HIV positive, gestational age and institutional delivery were significant predictors for HBsAg sero-positivity. Early initiation of antenatal care service that integrate awareness creation about the risks of hepatitis B infection and mother to child transmission of the disease must be implemented by the health facilities in Gedio Zone.
A Retrospective Study of Dental Changes after Facial Contouring Surgery
Authors: Park Jong Chul 
Published: September 2020

Abstract
Background: The purpose of this study was to confirm whether long-term dental changes after people were aged beyond their 20s would be affected by undergoing facial contouring surgery, such as angle and zygoma reduction. Additionally, we intended to verify whether these changes would be significantly different depending on the type of contouring surgery.Methods: We included 77 subjects who underwent contouring surgery from December 13, 2011, to December 3, 2018. Of these subjects, 73 were female, and 5 were male. We followed up with these patients from 11 to 82 months after surgery. The average follow-up period was 33.6 months. The age at surgery was 18 to 48 years old. The average age was 29.5 years old. To assess dental changes, we measured variables such as the extrusion of a maxillary anterior and posterior tooth, angle from point A to nasion to point B (ANB°) change, and overjet/overbite change between pre- and postoperative periods using computed tomography.Results: There was a positive linear correlation between the extrusion of the maxillary teeth and the follow-up period. The correlation coefficients of incisors and molars were 0.454 and 0.461, respectively (p = 0.000 for incisors and 0.000 for molars). With age, there was also a negative correlation in extrusion. The correlation coefficient was -0.442 for incisors and -0.394 for molars (p = 0.000 for incisors and 0.000 for molars). We also confirmed significant differences in incisor extrusion and ANB° change depending on the type of surgery (p = 0.018 for incisor extrusion and 0.003 for ANB°).Conclusion: We observed dental changes in subjects who underwent facial contouring surgery, and these changes were affected by the type of operation.
Impact of a pandemic on surgical neuro-oncology - maintaining functionality in crisis
Authors: Hameed N. U. Farrukh , Ma Yixin , Zhen Zili , Wu Shuai , Feng Rui , Li Weiping , Huang Guodong , Wu Jinsong , Chen Zhongping 
Published: September 2020

Abstract
Background: The Coronavirus disease 2019 (COVID-19) pandemic has extraordinarily impacted global healthcare. Neuro-oncological surgery units have peculiar features that make them highly relevant in the strategic reaction to the pandemic. In this Chinese Society of Neuro-Oncology (CSNO) initiated survey, we appraise the changes implemented in neurosurgery hospitals across different Asian countries and provide expert recommendations for responses at different stages of the pandemic.Methods: A 42-question survey was distributed to neurosurgery hospitals across different Asian countries by the CSNO on April 1, 2020, with responses closed on April 18, 2020.Results: 144 hospitals completed the questionnaire. Most were in WHO post-peak phase of the pandemic and reported a median reduction in neurosurgery volume of 25-50%. Most(67.4%) resumed elective surgery in only COVID-19 negative patients;11.1% performed only emergency cases irrespective of COVID-19 status;2.1% suspended all surgical activity. Ninety-one(63.2%) relocated personnel from neurosurgery to other departments. Fifty-two(36.1%) hospitals suspended post-operative adjuvant therapy and 94(65.2%) instituted different measures to administer post-operative adjuvant therapy. Majority(59.0%) of the hospitals suspended research activity. Most(70%) respondents anticipate that current neurosurgery restrictions will continue to remain for >1 month.Conclusions: Majority of the respondents to our survey reported reduced neurosurgery activity, policy modification, personnel reallocation, and curtailment of educational/research activities in response to the COVID-19 pandemic. The persistent widespread interruption of surgical neuro-oncology in even post-peak phases of the pandemic raises serious concerns about the long-term impact of the pandemic on neuro-oncological patients and highlights the essence of timely measures for pandemic preparedness, patient triage, and workforce protection.
A New Quasi Sujatha Distribution
Authors: Shanker Rama , Shukla Kamlesh Kumar 
Published: September 2020

Abstract
The aim of this paper is to introduce a new quasi Sujatha distribution (NQSD), of which the following are particular cases: the Sujatha distribution devised by Shanker (2016 a), the size-biased Lindley distribution, and the exponential distribution. Its moments and moments-based measures are derived and discussed. Statistical properties, including the hazard rate and mean residual life functions, stochastic ordering, mean deviations, Bonferroni and Lorenz curves and stress-strength reliability are also analysed. The method of moments and the method of maximum likelihood estimations is discussed for estimating parameters of the proposed distribution. A numerical example is presented to test its goodness of fit, which is then compared with other one-parameter and two-parameter lifetime distributions.
Withdrawal Notice: Reconnoitering the Role of Endothelin in Obesity
Authors: Behl Tapan , Nijhawan Priya , Sachdeva Monika , Kumar Arun , Uddin Md. Sahab , Kotwani Anita , Zengin Gokhan , Khullar Gaurav , Sharma Himankar , Kaur Ishnoor , Arora Sandeep 
Published: September 2020

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Evaluation of an Occupational Exercise Training Program for Firefighters: Mixed Methods Pilot Study
Authors: Leary Miriam , Thomas James , Hayes Ryan , Sherlock Lori 
Published: September 2020

Background
Occupational exercise training programs can improve overall health and fitness in firefighters, but evidence beyond clinical and performance outcomes is needed before fire departments invest in and successfully adopt health promotion programs.

Objective
This mixed methods pilot study sought to pair clinical and performance outcomes with participants’ qualitative feedback (eg, participants’ enjoyment, lifestyle behavior changes, and team structure) with the goal of informing recommendations for future programs.

Methods
Professional firefighters participated in a 14-week occupational exercise training program with assessments conducted pre- and posttraining. Clinical outcomes included weight, BMI, body fat percentage, resting heart rate, systolic blood pressure, and diastolic blood pressure. Performance outcomes included the sharpened Romberg balance test, 1-repetition maximum leg press and bench press, graded exercise test (estimated VO2max), knee range of motion, shoulder flexibility, and hamstring flexibility. Self-administered surveys (Short Form-36, International Physical Activity Questionnaire, Barriers Self-Efficacy Scale, and Barriers to Being Active Quiz) were completed. In 3 private focus groups of 3 to 4 participants, firefighters' experiences in the training program and their health behaviors were explored.

Results
Male firefighters (n=14; age: mean 36.4, SD 2.6 years) completed 20 training sessions. There were no significant changes to weight (P=.20), BMI (P=.15), body fat percentage (P=.16), systolic blood pressure (P=.12), estimated VO2max (P=.34), balance (P=.24), knee range of motion (left: P=.35; right: P=.31), or hamstring flexibility (P=.14). There was a significant decrease in diastolic blood pressure (P=.04) and significant increases in shoulder flexibility (P<.001) and leg press 1-repetition maximum volume (P=.04). Participants reported improvements in overall health, endurance, flexibility, and mood as well as improvements to team environment and health behaviors around the station; however, there was a decline in overcoming barriers to physical activity.

Conclusions
A 14-week program of exercise training in firefighters elicited improvements in clinical, performance, and self-reported physical activity outcomes. This occupational exercise training program for firefighters increased time spent exercising, improved team building, and led to physical and mental health benefits. Results from this pilot study set a broad, informed, and meaningful foundation for future efforts to increase firefighter participation in occupational fitness programs.