bluuebunny/crossref_metadata_2025_split huggingface dataset:
Angler Experience and Seasonal Effects on the Response of the Lake Sturgeon to Catch‐and‐Release Angling
Authors: Mullen Eric J. , Schoen Alexandra N. , Hauger McKenzie D. , Murray Lee , Anderson W. Gary 
Published: August 2020

AbstractLake Sturgeon Acipenser fulvescens, once widespread throughout North America, are now considered endangered in much of their natural range. However, recreational catch‐and‐release (C&R) fisheries targeting the Lake Sturgeon have developed in areas with strong populations. Here, we evaluated physiological and behavioral impairment of Lake Sturgeon after C&R angling. Fish were angled from the Winnipeg River and transferred to a holding pen to recover and facilitate serial sampling after angling. Measured physiological traits included blood osmolality, pH, glucose, and cortisol concentration. Behavioral impairment was measured as a binary score using reflex action mortality predictors in addition to ventilation rate. The effects of season and angler experience on these measured variables were assessed. Catch‐and‐release angling resulted in an immediate physiological stress response and behavioral impairment in all Lake Sturgeon regardless of treatment. Generally, we observed a recovery in acid–base balance, ion balance, and reflex impairment by 24 h; however, cortisol and glucose were elevated throughout the recovery period, possibly indicating interactive stressors of holding and repeat sampling. Angling in the summer period caused increased ventilation rate and decreased osmolality at all timepoints compared to angling in the spring. In comparison with experienced anglers, novice anglers caused higher reflex impairment in Lake Sturgeon immediately after capture. This is the first study to examine the response of wild Lake Sturgeon to C&R angling. Data show an apparent resilience of Lake Sturgeon to C&R and can be used to assess the validity of C&R as a management strategy in the conservation of Lake Sturgeon.
Integrated optimal wind‐resistant design of super‐tall structures with toggle‐brace damper systems
Authors: Zhao Xin , Guo Junchen , Ma Haojia , Ding Kun 
Published: August 2020

SummaryWith the increasing heights of super‐tall buildings, the natural frequency of these structures approaches the predominant frequency of winds, causing the structures to be more sensitive to wind load. For the safety and economy of these structures, the formulation of a reasonable wind‐resistant design is crucial. In this paper, an optimal design of toggle‐brace damper systems for super‐tall buildings using a damping ratio limit method is presented to obtain the optimal placement, number, and damping coefficient of toggle‐brace dampers under different constraints. The constraints include the additional damping ratio under a 50‐year return period wind, the maximum power of the damper under a 50‐year return period wind, and the maximum output force of a moderate earthquake. The toggle‐brace damper systems improve the structural performance. Hence, the structural components produce design redundancy, which can be optimized using the sequential quadratic programming (SQP) algorithm and a multi‐grade constrained optimal design method to further improve the economic benefits of the structure. Based on the combination of the optimal design method of toggle‐brace damper systems, SQP algorithm, and multi‐grade constrained optimal design method, an integrated optimal wind‐resistant design for toggle‐brace damper systems is proposed. To demonstrate the effectiveness and applicability of this design, a 245‐m super‐tall building is employed as an engineering case.
Genome‐wide mapping and prediction of plant architecture in a sorghum nested association mapping population
Authors: Olatoye Marcus O. , Hu Zhenbin , Morris Geoffrey P. 
Published: August 2020

AbstractModifying plant architecture is often necessary for yield improvement and climate adaptation, but we lack understanding of the genotype‐phenotype map for plant morphology in sorghum. Here, we use a nested association mapping (NAM) population that captures global allelic diversity of sorghum to characterize the genetics of leaf erectness, leaf width (at two stages), and stem diameter. Recombinant inbred lines (n = 2200) were phenotyped in multiple environments (35,200 observations) and joint linkage mapping was performed with ∼93,000 markers. Fifty‐four QTL of small to large effect were identified for trait BLUPs (9–16 per trait) each explaining 0.4–4% of variation across the NAM population. While some of these QTL colocalize with sorghum homologs of grass genes (e.g., those involved in transcriptional regulation of hormone synthesis [rice SPINDLY] and transcriptional regulation of development [rice Ideal plant architecture1]), most QTL did not colocalize with an a priori candidate gene (92%). Genomic prediction accuracy was generally high in five‐fold cross‐validation (0.65–0.83), and varied from low to high in leave‐one‐family‐out cross‐validation (0.04–0.61). The findings provide a foundation to identify the molecular basis of architecture variation in sorghum and establish genomic‐enabled breeding for improved plant architecture.
Exploiting molecular probes to perform near‐infrared fluorescence‐guided surgery
Authors: Wu Yifan , Zhang Fan 
Published: August 2020

AbstractNear‐infrared (NIR) fluorescence imaging can provide real‐time navigation for surgeons to discriminate boundaries between lesions and healthy tissue, which serves as a promising tool to enhance precise diagnosis and accurate excision during surgery. Molecular probes with NIR fluorescence can visualize diseased tissue in deep penetration with improved signal‐to‐noise ratio, which considerably encourages the active participation of NIR fluorescence‐guided surgery in the operating room. Although a great quantity of fluorescent probes has been employed in clinical trials, the U.S. Food and Drug Administration only approves an extremely narrow number of contrast agents for clinical use so far. Currently, there remain two significant problems to be addressed in surgical resection: accurate identification of diseased tissue and the preservation of adjacent vital structures. Here, molecular probes with NIR fluorescence are systematically reviewed to offer possible solutions to these two problems. Targeting strategies of fluorescent probes are introduced, where the strengths and weaknesses of each strategy are presented. Advances in fluorescent probes for the imaging of vital structures, such as nerve and ureter, are also summarized in this review. It is convinced that NIR fluorescence‐guided surgery has the potential to improve current surgical resection and ameliorate the postoperative outcomes of diverse diseases.
Thermoplastic polyurethane (TPU) modifier to develop bimodal cell structure in polypropylene/TPUmicrocellular foam in presence of supercriticalCO2
Authors: Wang Jie , Li Jun , Li Hui , Zhou Hongfu 
Published: August 2020

AbstractCurrently, the fabrication of microcell and bimodal cell structures (BCS) in polymer foams by using supercritical fluids has become a hot as well as a challenging research area worldwide. In this work, an environmentally friendly, effective, facile, and CO2‐based foaming technique was presented to fabricate microcellular polypropylene (PP) foams with BCS via blending with thermoplastic polyurethane (TPU). The toughness, thermal properties, rheological properties, and foamability of PP were systematically investigated with gradual incorporation of TPU. Representative sea‐island structure was observed in the scanning electron microscopy (SEM) images for the fracture surface of various PP/TPU samples. Rheological measurement results demonstrated that the viscoelasticity of various PP/TPU samples was improved remarkably compared with that of pure PP and pure TPU. The impact strength of various PP/TPU samples possessed the highest value as 12.4 kJ/m2with the TPU content of 15 wt%. After the addition of TPU, an ameliorative cellular morphology was observed in the SEM micrographs of various PP/TPU samples and their volume expansion ratio was enhanced significantly thanks to their improved melt elasticity. Moreover, it is worth noting that BCS appeared in various PP/TPU foams when the TPU content exceeded 5 wt%.
The clinical and educational outcomes of an inter-professional student-led medication review team, a pilot study
Authors: Reumerman Michael O. , Richir Milan C. , Domela Nieuwenhuis Philippe M. , Sultan Rowan , Daelmans Hester E. M. , Springer Hans , Muller Majon , van Agtmael Michiel A. , Tichelaar Jelle 
Published: August 2020

Abstract
Aims
The involvement of an inter-professional healthcare student team in the review of medications used by geriatric patients could not only provide patients with optimized therapy but also provide students with a valuable inter-professional learning experience. We describe and evaluate the clinical and learning outcomes of an inter-professional student-run mediation review program (ISP).

Subject and method
A variable team consisting of students in medicine, pharmacy, master advanced nursing practice, and master physician assistant reviewed the medication lists of patients attending a specialized geriatric outpatient clinic.

Results
During 32 outpatient visits, 188 medications were reviewed. The students identified 14 medication-related problems, of which 4 were not recognized by healthcare professionals. The ISP team advised 95 medication changes, of which 68 (71.6%) were directly implemented. Students evaluated this pilot program positively and considered it educational (median score 4 out of 5) and thought it would contribute to their future inter-professional relationships.

Conclusion
An inter-professional team of healthcare students is an innovative healthcare improvement for (academic) hospitals to increase medication safety. Most formulated advices were directly incorporated in daily practice and could prevent future medication-related harm. The ISP also offers students a first opportunity to work in an inter-professional manner and get insight into the perspectives and qualities of their future colleagues.
Decreased hemoglobin as a quantifiable indicator of renal arterial embolization in post-percutaneous nephrolithotomy hemorrhage
Authors: Ran Ruitu , Zhang Ruiyuan , Xie Ye , Yin Zhikang 
Published: August 2020

AbstractTo determine quantifiable indicators for post-percutaneous nephrolithotomy (PCNL) renal arterial embolization. A total of 2043 patients who underwent PCNL from September 2012 to March 2018 were reviewed retrospectively. Post-operative hemorrhage patients were extracted and divided into two groups according to treatment methods (conservative methods or super-selective renal arterial embolization [SRAE]). Demographic characteristics and hemorrhage outcomes were compared between the two groups by univariable analysis. Multivariable logistic regression was used to reveal the association between hemorrhage outcome factors and SRAE. A receiver operating characteristic (ROC) curve was drawn to determine the optimized cut-off value for SRAE. We identified 71 patients who had post-PCNL hemorrhage. Seventeen and 54 patients comprised the SRAE and conservative groups, respectively. No significant differences in demographic characteristics were found between the two groups. Univariate analysis showed that the differences in decreased hemoglobin (Hb), hemorrhage types, and transfusion were significant between the two groups (p < 0.001). Multivariable analysis showed that the decreased Hb was closely associated with the risk of SRAE. The ROC curve showed that an adjusted Hb decrease of 3.45 g/dL was an optimum indicator (AUC = 0.925). Decreased Hb is an indicator for SRAE after PCNL. When the adjusted decrease in Hb is ≥ 3.45 g/dL, SRAE should be performed regardless of the manifestations of hemorrhage.
National diabetes registries: do they make a difference?
Authors: Bak Jessica C. G. , Serné Erik H. , Kramer Mark H. H. , Nieuwdorp Max , Verheugt Carianne L. 
Published: August 2020

Abstract
Aims
The global epidemic of diabetes mellitus continues to expand, including its large impact on national health care. Measuring diabetes outcomes and their causes of variation highlights areas for improvement in care and efficiency gains; large registries carry this potential. By means of a systematic review, we aimed to give an overview of national registries worldwide by quantifying their data and assessing their influence on diabetes care.

Methods
The literature on MEDLINE up to March 31, 2020, was searched, using keywords diabetes mellitus, national, registry, registration, and/or database. National disease-specific registries from corresponding articles were included. Database characteristics and clinical variables were obtained. All registries were compared to the ICHOM standard set of outcomes.

Results
We identified 12 national clinical diabetes registries, comprising a total of 7,181,356 diabetic patients worldwide. Nearly all registries recorded weight, HbA1c, lipid profile, and insulin treatment; the recording of other variables varied to a great extent. Overall, registries corresponded fairly well with the ICHOM set. Most registries proved to monitor and improve the quality of diabetes care using guidelines as a benchmark. The effects on national healthcare policy were more variable and often less clear.

Conclusions
National diabetes registries confer clear insights into diagnostics, complications, and treatment. The extent to which registries influenced national healthcare policy was less clear. A globally implemented standard outcome set has the potential to improve concordance between national registries, enhance the comparison and exchange of diabetes outcomes, and allocate resources and interventions where most needed.
Prognostic impact of the preoperative hemoglobin A1c levels in patients with gastric cancer surgery depends on postoperative complications
Authors: Shibamoto Jun , Shoda Katsutoshi , Kubota Takeshi , Kosuga Toshiyuki , Kubo Hidemasa , Ohashi Takuma , Shimizu Hiroki , Arita Tomohiro , Yamamoto Yusuke , Konishi Hirotaka , Morimura Ryo , Shiozaki Atsushi , Kuriu Yoshiaki , Ikoma Hisashi , Fujiwara Hitoshi , Okamoto Kazuma , Otsuji Eigo 
Published: August 2020

Abstract
Purpose
The long-term prognostic impact of the hemoglobin A1c levels has not yet been evaluated in patients with gastric cancer. The present study investigated the clinical significance of the hemoglobin A1c levels in patients with gastric cancer.

Methods
We enrolled 294 patients with stage II, III, or IV gastric cancer who underwent gastrectomy. The patients were divided into high preoperative hemoglobin A1c (> 6.0%) and low preoperative hemoglobin A1c (≤ 6.0%) groups.

Results
In patients with stage III gastric cancer with severe postoperative complications, the high preoperative hemoglobin A1c group had a significantly worse prognosis than the low preoperative hemoglobin A1c group (p = 0.0409). In patients without severe postoperative complications, the high preoperative hemoglobin A1c group had a significantly favorable prognosis compared with the low preoperative hemoglobin A1c group (p = 0.0348).

Conclusion
The prognosis of patients with stage III gastric cancer having high preoperative hemoglobin A1c levels greatly depended on the presence or absence of postoperative complications. To avoid postoperative complications, optimal perioperative management and personalized treatments are critical, particularly for these patients.
Guidelines versus evidence: what we can learn from the Australian guideline for low-level laser therapy in knee osteoarthritis? A narrative review
Authors: Chow Roberta , Liebert Ann , Tilley Sharon , Bennett Gregory , Gabel C. Philip , Laakso Liisa 
Published: August 2020

AbstractThis narrative review analyses the Australian Guideline (2018) for the treatment of knee osteoarthritis (KOA) developed using Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. The Guideline recommended against the use low-level laser therapy (LLLT). Why this conclusion was reached is discussed in this review in the context of evidence provided in other systematic reviews, the latest of which was published in 2019 and which provided strong support for LLLT for knee OA. We evaluated the reference list cited for the recommendation “against” LLLT and compared this with reference lists of systematic reviews and studies published before and after the publication date of the Guideline. Eight randomised controlled trials (RCTs) of LLLT were cited in the Guideline the latest of which was published in 2012. There were seventeen additional RCTs, five of which together with one systematic review were located in the year of publication, 2018. The most recent systematic review in 2019 included 22 RCTs in its analysis. Discordance with the levels of evidence and recommendations was identified. Although GRADE methodology is said to be robust for systematically evaluating evidence and developing recommendations, many studies were not identified in the Guideline. In contrast, the latest systematic review and meta-analysis provides robust evidence for supporting the use of LLLT in knee OA. The conflict between guidelines based on opinion and evidence based on meta-analysis is highlighted. Given the totality of the evidence, we recommend that the Australian Guideline should be updated immediately to reflect a “for” recommendation.
Passive bilateral leg cycling with concomitant regional circulatory occlusion for testing mechanoreflex–metaboreflex interactions in humans
Authors: Lis Adrian , Łopusiewicz Wojciech , Piepoli Massimo F. , Ponikowska Beata , Paleczny Bartłomiej 
Published: August 2020

Abstract
Purpose
The exercise pressor reflex (EPR) plays a fundamental role in physiological reactions to exercise in humans and in the pathophysiology of cardiovascular disorders. There is no “gold standard” method for EPR assessment; therefore, we propose a new protocol for testing interactions between the muscle mechanoreflex and metaboreflex (major components of EPR).

Methods
Thirty-four healthy subjects (mean age [± standard deviation] 24 ± 4 years, 22 men) were enrolled in the study. During the study, the hemodynamic and ventilatory parameters of these subjects were continuously monitored using our proposed assessment method. This assessment method consists of an initial 5-min rest period (baseline) followed by 5 min of passive cycling (PC) on an automated cycle ergometer (mechanoreceptor stimulation), after which tourniquet cuffs located bilaterally on the upper thighs are inflated for 3 min to evoke venous and arterial regional circulatory occlusion (CO) during PC (metaboreceptor stimulation). Deflation of the tourniquet cuffs is followed by a second 5 min of PC and finally by a 5-min recovery time. The control test comprises a 5-min rest period, followed by 3 min of CO only and a final 5-min recovery.

Results
Mean arterial pressure (MAP) and minute ventilation (MV) increased significantly during PC (MAP: from 90 ± 9.3 to 95 ± 9.7 mmHg; MV: from 11.5 ± 2.5 to 13.5 ± 2.9 L/min; both p < 0.05) and again when CO was applied (MAP: from 95 ± 9.7 to 101 ± 11.0 mmHg; MV: from 13.5 ± 2.9 to 14.8 ± 3.8 L/min; both p < 0.05). In the control test there was a slight increase in MAP during CO (from 92 ± 10.5 to 94 ± 10.0 mmHg; p < 0.05) and no changes in the ventilatory parameters.

Conclusion
Bilateral leg passive cycling with concomitant circulatory occlusion is a new, simple and effective method for testing interactions between the mechanoreflex and metaboreflex in humans.
Direct Numerical Simulations of the Evaporation of Dilute Sprays in Turbulent Swirling Jets
Authors: Ciottoli P. P. , Battista F. , Malpica Galassi R. , Dalla Barba F. , Picano F. 
Published: August 2020

AbstractThe effects of swirled inflows on the evaporation of dilute acetone droplets dispersed in turbulent jets are investigated by means of direct numerical simulation. The numerical framework is based on a hybrid Eulerian–Lagrangian approach and the point-droplet approximation. Phenomenological and statistical analyses of both phases are presented. An enhancement of the droplet vaporization rate with increasing swirl velocities is observed and discussed. The key physical drivers of this augmented evaporation, namely dry air entrainment and swirl-induced centrifugal forces acting on the droplets, are isolated with the aid of additional simulations in which the inertial properties of the droplets are neglected. The correlation between swirl and dry air entrainment rate is found to be responsible for the increase of the global evaporation rate and the spray penetration length reduction, while swirl-induced centrifugal forces are found to be effective only in the jet shear layer, close to the injection orifice, for the analyzed cases.
Is a colorectal neoplasm diagnosis a trigger to change dietary and other lifestyle habits for persons with Lynch syndrome? A prospective cohort study
Authors: Brouwer Jesca G. M. , Snellen Merel , Bisseling Tanya M. , Koornstra Jan Jacob , Vasen Hans F. A. , Kampman Ellen , van Duijnhoven Fränzel J. B. 
Published: August 2020

AbstractA cancer diagnosis is suggested to be associated with changes in dietary and lifestyle habits. Whether this applies to persons with familial cancer, such as Lynch syndrome (LS) is unknown. We investigated whether a colorectal neoplasm (CRN) diagnosis in persons with LS is associated with changes in dietary and lifestyle habits over time. We used data of confirmed LS mutation carriers from the GEOLynch study, a prospective cohort study. Information on dietary intake and lifestyle habits was collected with a validated semi-quantitative food frequency questionnaire and a general questionnaire administered at baseline (2006–2008) and follow-up (2012–2017). Participants’ medical records were used to identify CRN diagnoses. Changes in dietary and lifestyle habits in the CRN and the no-CRN group were compared using multivariable linear regression models for continuous variables and cross-tables with percentage change at follow-up compared with baseline for categorical variables. Of the 324 included participants, 146 developed a CRN (CRN group) between baseline and follow-up, while 178 did not (no-CRN group). Smoking cessation was more often reported in the CRN than in the no-CRN group (41.4% vs. 35.0%). There were no differences in changes of energy intake, alcohol, red meat, processed meat, dairy, fruit, vegetables and dietary fiber consumption, BMI, physical activity and NSAID use. Apart from a potentially higher likelihood of smoking cessation, we found little evidence that a CRN diagnosis is associated with changes in lifestyle habits in persons with LS.