bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Energy Bound in the Affine Group
Authors: Petridis Giorgis , Roche-Newton Oliver , Rudnev Misha , Warren Audie 
Published: May 2020

Abstract
We prove a nontrivial energy bound for a finite set of affine transformations over a general field and discuss a number of implications. These include new bounds on growth in the affine group, a quantitative version of a theorem by Elekes about rich lines in grids. We also give a positive answer to a question of Yufei Zhao that for a plane point set $P$ for which no line contains a positive proportion of points from $P$, there may be at most one line, meeting the set of lines defined by $P$ in at most a constant multiple of $|P|$ points.
Enhanced Human Immunodeficiency Virus-1 Replication in CD4+ T Cells Derived From Individuals With Latent Mycobacterium tuberculosis Infection
Authors: He Xianbao , Eddy Jared J , Jacobson Karen R , Henderson Andrew J , Agosto Luis M 
Published: May 2020

AbstractBackgroundMycobacterium tuberculosis (Mtb) and human immunodeficiency virus (HIV) coinfection increases mortality, accelerates progression to acquired immune deficiency syndrome, and exacerbates tuberculosis disease. However, the impact of pre-existing Mtb infection on subsequent HIV infection has not been fully explored. We hypothesized that Mtb infection creates an immunological environment that influences the course of HIV infection, and we investigated whether pre-existing Mtb infection impacts the susceptibility of CD4+ T cells to HIV-1 infection.MethodsPlasma and blood CD4+ T cells isolated from HIV-negative individuals across the Mtb infection spectrum and non-Mtb-infected control individuals were analyzed for inflammation markers and T-cell phenotypes. CD4+ T cells were infected with HIV-1 in vitro and were monitored for viral replication.ResultsWe observed differences in proinflammatory cytokines and the relative proportion of memory T-cell subsets depending on Mtb infection status. CD4+ T cells derived from individuals with latent Mtb infection supported more efficient HIV-1 transcription, release, and replication. Enhanced HIV-1 replication correlated with higher percentages of CD4+ TEM and TTD cells.ConclusionsPre-existing Mtb infection creates an immunological environment that reflects Mtb infection status and influences the susceptibility of CD4+ T cells to HIV-1 replication. These findings provide cellular and molecular insights into how pre-existing Mtb infection influences HIV-1 pathogenesis.
Quality and safety in the time of Coronavirus: design better, learn faster
Authors: Fitzsimons John 
Published: May 2020

Abstract
The COVID-19 pandemic has required health systems to change much faster than normal. Many staff have experienced training in quality improvement and patient safety methods which can be used to support the design of new systems and to accelerate learning about new and adapted practices. This article sets out the principles of quality improvement and patient safety science, applying them in a selection of approaches, methods and tools, which may be useful in crisis situations such as the current pandemic. The article also makes reference to several resources which may be of use to those keen to advance their knowledge.
The Diversity of Hornets in the Genus Vespa (Hymenoptera: Vespidae; Vespinae), Their Importance and Interceptions in the United States
Authors: Smith-Pardo Allan H , Carpenter James M , Kimsey Lynn 
Published: May 2020

AbstractHornets in the genus Vespa (Vespidae, Vespinae) are social wasps. They are primarily predators of other insects, and some species are known to attack and feed on honeybees (Apis mellifera L.), which makes them a serious threat to apiculture. Hornet species identification can be sometimes difficult because of the amount of intraspecific color and size variation. This has resulted in many species-level synonyms, scattered literature, and taxonomic keys only useful for local populations. We present a key to the world species, information on each species, as well as those intercepted at United States Ports of Entry during the last decade. Images of all the species and some of the subspecies previously described are also included.
Latent bias and the implementation of artificial intelligence in medicine
Authors: DeCamp Matthew , Lindvall Charlotta 
Published: May 2020

Abstract
Increasing recognition of biases in artificial intelligence (AI) algorithms has motivated the quest to build fair models, free of biases. However, building fair models may be only half the challenge. A seemingly fair model could involve, directly or indirectly, what we call “latent biases.” Just as latent errors are generally described as errors “waiting to happen” in complex systems, latent biases are biases waiting to happen. Here we describe 3 major challenges related to bias in AI algorithms and propose several ways of managing them. There is an urgent need to address latent biases before the widespread implementation of AI algorithms in clinical practice.
Effects of source and concentration of neutral detergent fiber from roughage in beef cattle diets: Comparison of methods to measure the effectiveness of fiber
Authors: Goulart Rodrigo S , Vieira Ricardo A M , Daniel Joao L P , Amaral Rafael C , Santos Vanessa P , Toledo Filho Sergio G , Cabezas-Garcia Edward H , Tedeschi Luis O , Nussio Luiz Gustavo 
Published: May 2020

Abstract
Methods have been developed to measure the effectiveness of many roughages, but few evaluations have been conducted with tropical feeds. The objectives of this research were to determine the effectiveness of roughage sources based on bioassay and laboratory methods and identify the biological attributes of the diets that correlate with these methods. Six ruminally cannulated Nellore steers (408 ± 12 kg of BW) were randomly assigned to a 6 × 6 Latin square design within six diets: negative control diet (NC) with aNDF as 10% from corn silage (CS); positive control diet (PC) with aNDF as 20% from CS; and four diets containing 10% aNDF from CS and 10% aNDF from each of the following sources: sugarcane (SC), sugarcane bagasse (SCB), soybean hulls (SH), or low oil cottonseed hulls (LOCH). Physical effectiveness factor (pef, related to the physical characteristics of aNDF) and effectiveness factor (ef, related to the ruminal pH) were determined based on a linear model approach that uses a bioassay method in which CS aNDF was assumed to be the standard fiber source. Laboratory methods to estimate pef of roughage sources were based on the proportion of DM of roughage retained on a 1.18-mm sieve pef(&gt;1.18 mm) or retained on the 8.0-mm Penn State Particle Separator screen pef(&gt;8.0 mm). The pef calculated by the bioassay method (total chewing time and ruminal mat resistance) for CS, SCB, and SC were higher values (P &lt; 0.05) compared with SH and LOCH. The pef(rumen mat) of SC and SCB were higher (P &lt; 0.05) than that of CS, SH, and LOCH. The pef(rumen mat) of LOCH was 61% higher than SH. The ef(rumen pH) of SC and LOCH was higher (P &lt; 0.05) than CS and SH. The pef(chewing, min/d), pef(chewing, min/kg of DM), pef(rumen mat), and ef(rumen pH) positively correlated with rumination time, total chewing time, and ruminal mat resistance (values from transit time in seconds). No correlation was observed (P &gt; 0.05) between pef(&gt;8.0 mm) and rumination time, chewing time, and ruminal pH. The pef calculated using the bioassay method as well as pef (&gt;8.0 mm) were negatively correlated with rumen pH (P &gt; 0.05). The values of the effectiveness of fiber sources obtained in this research can be used as a guideline for nutritionists aiming to replace roughage sources from tropical regions in beef cattle finishing diets. Under our conditions, the pef using the bioassay method or laboratory methods were not adequate in predicting ruminal pH.
Machine tool architecture selection at the preliminary design stage: application to hard material machining
Authors: Lajili Montassar , Chanal Hélène , Bouzgarrou Belhassen Chedli 
Published: May 2020

Abstract
The preliminary design stage ensures to evaluate machine tool performances according to the simulation of reduced models. Performance criteria are defined regarding the attempted machining process requirements. In our case, we study the problem of machine tool design for hard metal cutting, where a high level of stiffness is required. In this context, this paper’s aim is to introduce a new methodology of machine tool architectures modeling, optimization, and selection with regards to their stiffness and dynamic performances at the preliminary design stage. However, this type of study requires a quantitative evaluation of performance indicators. Studied machine tool structures are modelled with simplified shape parts. The dimensions of these parts are defined as design variables. Afterward, for each considered architecture, parametric design optimization is performed to minimize its mass under the constraint of a minimal attempted stiffness all over the workspace. This approach allowed restricting the total number of machine tool architectures to be detailed further and analyzed more accurately. In a first time, the paper includes an illustration of the developed methodology through an example of machine tool architecture evaluation and optimization. In a second time, the method is used to compare different kinds of machine tool architectures regarding their ability to be light for an attempted stiffness.
Effects of the publication of Clinical Guidelines for the Management of Chemotherapy-Induced Peripheral Neuropathy on the Administration Preferences of Oncology Specialists: Japanese Association of Supportive Care in Cancer
Authors: Hirayama Yasuo , Yoshida Yoichiro , Mori Masanori , Tamura Kazuo 
Published: May 2020

Abstract

Objective
We conducted a questionnaire survey of oncology specialists to investigate the frequency of administration of different drugs for the management of chemotherapy-induced peripheral neuropathy in Japan in 2015. Our group published Clinical Guidelines for the Management of Chemotherapy-Induced Peripheral Neuropathy in 2017 (CIPN-GL2017). In these guidelines, we recommended duloxetine only. To verify the effect of the publication of the CIPN-GL2017, we conducted a questionnaire survey in 2019.

Methods
In 2015 and again in 2019, we investigated the use of vitamin B12, antiepileptic agents, duloxetine, antidepressants other than duloxetine, non-steroidal anti-inflammatory drugs, opioids and the Kampo compound (goshajinkigan) in a questionnaire employing a three-point scale wherein A implies routine or prophylactic administration, B implies occasional administration and C implies infrequent administration.

Results
We sent the questionnaires via email to 971 diplomates of the Subspecialty Board of Japanese Society of Medical Oncology in 2015 and 1239 diplomates in 2019. The administration ratio (A + B) of duloxetine for numbness and pain was 46.8 and 31.7%, respectively, in 2015 and 68.9% (P &lt; 0.01) and 73.1% (P &lt; 0.01) in 2019. In response to the question regarding awareness of the CIPN-GL2017, 53.2% of respondents to the 2019 questionnaire were aware of the CIPN-GL2017. Among the respondents with an awareness of the CIPN-GL2017, the prescription rate of duloxetine (78.3%) for pain was significantly higher than that among respondents without any awareness (67.4%).

Conclusions
It is possible that the publication of CIPN-GL2017 influenced administration preferences of oncology specialists.
Periventricular White Matter Alterations From Explosive Blast in a Large Animal Model: Mild Traumatic Brain Injury or “Subconcussive” Injury?
Authors: Kim Jung H , Goodrich James A , Situ Robert , Rapuano Amedeo , Hetherington Hoby , Du Fu , Parks Steve , Taylor Wesley , Westmoreland Ted , Ling Geoffrey , Bandak Faris A , de Lanerolle Nihal C 
Published: May 2020

Abstract
The neuropathology of mild traumatic brain injury in humans resulting from exposure to explosive blast is poorly understood as this condition is rarely fatal. A large animal model may better reflect the injury patterns in humans. We investigated the effect of explosive blasts on the constrained head minimizing the effects of whole head motion. Anesthetized Yucatan minipigs, with body and head restrained, were placed in a 3-walled test structure and exposed to 1, 2, or 3 explosive blast shock waves of the same intensity. Axonal injury was studied 3 weeks to 8 months postblast using β-amyloid precursor protein immunohistochemistry. Injury was confined to the periventricular white matter as early as 3–5 weeks after exposure to a single blast. The pattern was also present at 8 months postblast. Animals exposed to 2 and 3 blasts had more axonal injury than those exposed to a single blast. Although such increases in axonal injury may relate to the longer postblast survival time, it may also be due to the increased number of blast exposures. It is possible that the injury observed is due to a condition akin to mild traumatic brain injury or subconcussive injury in humans, and that periventricular injury may have neuropsychiatric implications.
Activation of CaMKII and GluR1 by the PSD-95-GluN2B Coupling-Dependent Phosphorylation of GluN2B in the Spinal Cord in a Rat Model of Type-2 Diabetic Neuropathic Pain
Authors: Zhu Ya-Bing , Jia Gai-Li , Wang Jun-Wu , Ye Xiu-Ying , Lu Jia-Hui , Chen Jia-Li , Zhang Mao-Biao , Xie Ci-Shan , Shen Yu-Jing , Tao Yuan-Xiang , Li Jun , Cao Hong 
Published: May 2020

Abstract
The mechanisms underlying type-2 diabetic neuropathic pain (DNP) are unclear. This study investigates the coupling of postsynaptic density-95 (PSD-95) to N-methyl-D-aspartate receptor subunit 2B (GluN2B), and the subsequent phosphorylation of GluN2B (Tyr1472-GluN2B) in the spinal cord in a rat model of type-2 DNP. Expression levels of PSD-95, Tyr1472-GluN2B, Ca2+/calmodulin-dependent protein kinase II (CaMKII) and its phosphorylated counterpart (Thr286-CaMKII), and α-amino-3-hydroxy-5-methyl-4-soxazole propionic acid receptor subtype 1 (GluR1) and its phosphorylated counterpart (Ser831-GluR1) were significantly increased versus controls in the spinal cord of type-2 DNP rats whereas the expression of total spinal GluN2B did not change. The intrathecal injection of Ro25-6981 (a specific antagonist of GluN2B) or Tat-NR2B9c (a mimetic peptide disrupting the interaction between PSD-95 and GluN2B) induced an antihyperalgesic effect and blocked the increased expression of Tyr1472-GluN2B, CaMKII, GluR1, Thr286-CaMKII, and Ser831-GluR1 in the spinal cords; the increase in spinal cord PSD-95 was not affected. These findings indicate that the PSD-95-GluN2B interaction may increase phosphorylation of GluN2B, and subsequently induce the expression of phosphorylation of CaMKII and GluR1 in the spinal cord of type-2 DNP rats. Targeting the interaction of PSD-95 with GluN2B may provide a new therapeutic strategy for type-2 DNP.
Long-term outcomes of induction chemotherapy followed by chemoradiotherapy using volumetric-modulated arc therapy as an organ preservation approach in patients with stage IVA-B oropharyngeal or hypopharyngeal cancers
Authors: Kubo Katsumaro , Murakami Yuji , Kenjo Masahiro , Imano Nobuki , Takeuchi Yuki , Nishibuchi Ikuno , Kimura Tomoki , Kawahara Daisuke , Ueda Tsutomu , Takeno Sachio , Nagata Yasushi 
Published: May 2020

Abstract
The present study aimed to analyze treatment outcomes after induction chemotherapy followed by chemoradiotherapy (CRT) using volumetric-modulated arc therapy (VMAT) in patients with stage IVA-B oropharyngeal cancer (OPC) or hypopharyngeal cancer (HPC), with long-term observation, including examination of larynx preservation. A total of 60 patients with stage IVA-B OPC or HPC, who underwent induction TPF chemotherapy (a combination regimen consisting of docetaxel, cisplatin, and 5-fluorouracil) followed by CRT using VMAT were analyzed. Overall survival (OS), progression-free survival (PFS), laryngoesophageal dysfunction-free survival (LEDFS), and locoregional control (LRC) were calculated and compared. Univariate and multivariate analyses were performed to determine statistical differences in OS and LEDFS. The median follow-up period at the time of evaluation was 61 months. Twenty-six (43%) patients had OPC and 34 (57%) had HPC. The 5-year OS, PFS, LEDFS, and LRC rates were 57%, 52%, 52%, and 68%, respectively. Response to TPF therapy was the only significant predictive factor of OS and LEDFS in multivariate analyses. Regarding long-term toxicities, grade ≥ 2 late toxicities accounted for 15%. No patients experienced grade ≥ 3 xerostomia, and 5% of all patients developed grade 3 dysphagia. With long-term observation, the OS, PFS, and LEDFS rates were relatively good, and the incidence of late toxicities was low. TPF followed by CRT using VMAT was feasible and more effective in those who responded to induction chemotherapy.
Perianal basal cell carcinoma: a common cancer in an uncommon location
Authors: Hagen Edward R , Hite Nathan , Griffin John , Kratz Rodney 
Published: May 2020

Abstract
This is a case of a perianal basal cell carcinoma, a common skin cancer in an unusual location. Our patient is a 67-year-old male with a perianal lesion. He first noticed this painless lesion 5 years prior to presentation and was having fecal incontinence and weight loss. He had a fully encompassing ulcerated lesion involving the entirety of the anal margin. We performed a biopsy that returned on pathology as a basal cell carcinoma. Due to the size of the lesion and his current nutritional status, it was determined to be unresectable. We were able to provide him with a diverting colostomy to address his incontinence and this allowed the patient to recover enough to undergo treatment with radiation (total of 5400 cGy). To our knowledge, this is the largest perianal basal cell carcinoma reported in the literature and an example of combining palliative surgery and radiation as a treatment option.
Small bowel obstruction caused by 18FDG-negative ileocecal metastasis of lobular breast carcinoma
Authors: Meekel Jorn P , Coblijn Usha K , Flens Marcel J , Muller Sandra , Boer den Frank C 
Published: May 2020

Abstract
Breast carcinoma is the most frequently diagnosed cancer in women. In up to 30%, distant metastases will occur; however, ileocecal metastases are rare. Although there have been cases reported that demonstrate ileocecal metastases of breast carcinoma, PET/CT-negative cases have never been described. We present a patient with a small bowel obstruction, preoperatively complicated by pulmonary embolisms. The patient underwent placement of an inferior vena cava filter followed by hemicolectomy. Pathological examination revealed ileocecal lobular breast carcinoma metastases and adjacent peritoneal carcinomatosis, which had shown no intestinal 18FDG uptake 7 weeks prior to presentation. Subsequently, symptoms of metastases and the paraneoplastic syndrome progressed, and the patient was referred to the medical oncologist for palliative therapy. Although uncommon, physicians should be aware of potential presence of 18FDG-negative gastrointestinal metastases of breast cancer.
Why is C4 photosynthesis so rare in trees?
Authors: Young Sophie N R , Sack Lawren , Sporck-Koehler Margaret J , Lundgren Marjorie R 
Published: May 2020

Abstract
Since C4 photosynthesis was first discovered &gt;50 years ago, researchers have sought to understand how this complex trait evolved from the ancestral C3 photosynthetic machinery on &gt;60 occasions. Despite its repeated emergence across the plant kingdom, C4 photosynthesis is notably rare in trees, with true C4 trees only existing in Euphorbia. Here we consider aspects of the C4 trait that could limit but not preclude the evolution of a C4 tree, including reduced quantum yield, increased energetic demand, reduced adaptive plasticity, evolutionary constraints, and a new theory that the passive symplastic phloem loading mechanism observed in trees, combined with difficulties in maintaining sugar and water transport over a long pathlength, could make C4 photosynthesis largely incompatible with the tree lifeform. We conclude that the transition to a tree habit within C4 lineages as well as the emergence of C4 photosynthesis within pre-existing trees would both face a series of challenges that together explain the global rarity of C4 photosynthesis in trees. The C4 trees in Euphorbia are therefore exceptional in how they have circumvented every potential barrier to the rare C4 tree lifeform.
Functional analysis of two STAT1 gain-of-function mutations in two Iranian families with autosomal dominant chronic mucocutaneous candidiasis
Authors: Ostadi Vajiheh , Sherkat Roya , Migaud Melanie , Modaressadeghi Seyed-Mehran , Casanova Jean-Laurent , Puel Anne , Nekooie-Marnany Nioosha , Ganjalikhani-Hakemi Mazdak 
Published: May 2020

Abstract
Candidiasis is characterized by susceptibility to recurrent or persistent infections caused by Candida spp., typically Candida albicans, of cutaneous and mucosal surfaces. In this report, function and frequency of Th17 cells as well as genetics of patients susceptible to mucocutaneous candidiasis were studied. For patients, T-cell proliferation tests in response to Candida antigen, Th17 cell proportions, and STAT1 phosphorylation were evaluated through flow cytometry. Expression of IL17A, IL17F and IL22 genes were measured by real-time quantitative PCR. At the same time, whole exome sequencing was performed for all patients. We identified two heterozygous substitutions, one: c.821G &gt; A (p. R274Q) was found in a multiplex family with three individuals affected, the second one: c.812A &gt; C (p. Q271P) was found in a sporadic case. Both mutations are located in the coiled-coil domain (CCD) of STAT1. The frequency of Th17 cells, IL17A, IL17F, and IL22 gene expression in patients’ peripheral blood mononuclear cells (PBMCs), and T-cell proliferation to Candida antigens were significantly reduced in the patients as compared to healthy controls. An increased STAT1 phosphorylation was observed in patients’ PBMCs upon interferon (IFN)-γ stimulation as compared to healthy controls. We report two different but neighboring heterozygous mutations, located in exon 10 of the STAT1 gene, in four Iranian patients with CMC, one of whom also had hypothyroidism. These mutations were associated with impaired T cell proliferation to Candida antigen, low Th17 cell proportions, and increased STAT1 phosphorylation upon IFN-γ. We suggest that interfering with STAT1 phosphorylation might be a promising way for potential therapeutic measurements for such patients.
The relationship between mid-infrared and sub-millimetre variability of deeply embedded protostars
Authors: Contreras Peña Carlos , Johnstone Doug , Baek Giseon , Herczeg Gregory J , Mairs Steve , Scholz Aleks , Lee Jeong-Eun ,   The JCMT Transient Team
Published: May 2020

ABSTRACT
We study the relationship between the mid-infrared (mid-IR) and sub-millimetre (sub-mm) variability of deeply embedded protostars using the multi-epoch data from the Wide-field Infrared Survey Explorer (WISE/NEOWISE) and the ongoing James Clerk Maxwell Telescope (JCMT) Transient Survey. Our search for signs of stochastic (random) and/or secular (roughly monotonic in time) variability in a sample of 59 young stellar objects (YSOs) revealed that 35 are variable in at least one of the two surveys. This variability is dominated by secular changes. Of those objects with secular variability, 14 objects ($22{{\ \rm per\ cent}}$ of the sample) show correlated secular variability over mid-IR and sub-mm wavelengths. Variable accretion is the likely mechanism responsible for this type of variability. Fluxes of YSOs that vary in both wavelengths follow a relation of log10F4.6(t) = ηlog10F850(t) between the mid-IR and sub-mm, with η = 5.53 ± 0.29. This relationship arises from the fact that sub-mm fluxes respond to the dust temperature in the larger envelope whereas the mid-IR emissivity is more directly proportional to the accretion luminosity. The exact scaling relation, however, depends on the structure of the envelope, the importance of viscous heating in the disc, and dust opacity laws.