bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construction company administration of intangible resources in the face of uncertainty
Authors: Peshkov A V 
Published: July 2020

AbstractManagement of intangible resources is an important component of a construction company’s business processes. The rapid development of information technology forces construction companies to change their usual activities and rebuild business processes in accordance with the challenges of the real market. It is digital technologies that are the object of the company’s intangible assets that can be used much more effectively to improve the current processes and information flows in the construction company. The advantages of the construction company’s intangible assets, such as Smart spaces, are that they provide increased efficiency and lower production costs, achieved through rational actions, the use of faster and more secure communication methods that guarantee the necessary flow of information. They also improve efficiency through rational and timely actions, with an emphasis on creating value and using new technologies. The economic effect of using information technologies, namely the introduction of Smart spaces, can be either direct, material in the form of achieved cost reduction and increased productivity of operations, or non-material, in the form of implemented patents and licenses, and improving the company’s image, as well as the potential of information technologies that can be used to make more effective decisions of a strategic nature.
Inefficiency of the current system of forming the initial maximum price of the contract of the state construction order
Authors: Pinchuk T O , Kazantseva I I 
Published: July 2020

Abstract
Management of the investment cycle of construction requires the development of adequate measures to the modern challenges of innovative forms and methods of state regulation in the field of construction. The existing mechanism for the placement and implementation of the state construction order allows us to conclude that the public procurement management system is insufficient and requires further improvement, based on the development priorities of the innovation environment and the investment attractiveness of construction investment projects. In particular, one of the main components for placing a state construction order is to determine the initial maximum contract price, which affects the conditions for the implementation of a state construction order. The existing approach to the formation of the initial maximum price does not meet modern realities. The methodological foundations of the formation of the initial maximum price of the contract by dividing it into basic and managed components are considered. The separation of controlled factors into qualitative and quantitative indicators is proposed. Based on the study, it follows that through controlled factors, it is possible to influence the initial maximum price of the contract by changing the quality factors in particular.
Numerical Investigation of the Aerodynamic Characteristics of a Missile
Authors: Meng Yu-shan , Yan Li , Huang Wei , Tong Xin-yu 
Published: July 2020

Abstract
During supersonic flight of supersonic missile, the missile configuration has great influence on the aerodynamic characteristics of the missile. This article evaluates the variation of the flow field results from the change of missile configuration by changing the shape of the head and the slenderness ratio of the body. The study is carried out by the CFD numerical method, and the structured grids are generated by ANSYS CFD software. We evaluate the aerodynamic characteristics of two-dimensional model and three-dimensional model by the flow solver FLUENT, and the standard Spalart-Allmaras one-equation is selected to simulate the flow around the missile, the results indicate that the drag coefficient of the oval head is less than parabolic head case and conical head case, and drag coefficient decreases with the increase of Mach number and slenderness ratio. With the increase of Mach number, the stagnation temperature increases correspondingly.
Method for Determining Takeoff Weight and Thrust-To-Weight Ratio of Aircraft Variants by Decision Speed with Engine Failed at Takeoff Run
Authors: Kapitanova L , Tiniakov D , Makarova L 
Published: July 2020

Abstract
In modern time the aircraft variants creation is main trend in the aviation industry. One the aspect of the aircraft safety is its safety take-off [1]. The aircraft parameters like relative take-off weight and thrust-to-weight ratio can determine many its performance include take-off. Their influence on decision speed during take-off of modified transport category airplanes are explored. The analytic model is simple and high efficiency way for the first approach of airplane`s safety analyses. The problem is solved by analytics modelling airplane motion on runway during take-off. Quantitative estimation of influence of the airplane weight and thrust-to-weight ratio variation on decision speed of continued or aborted take-off with critical engine failure is given on the base of example of heavy cargo airplane. The application of this way for the airplanes safety analysis is important for each types of aircraft. Estimation model is given in dimensionless parameters and so is applicable for any type of transport category airplanes.
Design and Simulation Analysis of Deployable Structure of a Single-unit Radar
Authors: Wang JinWei , Zhao XiFang , Tang BaoFu 
Published: July 2020

Abstract
The deployable structure has the characteristics of polymorphism, and it appears as the function of the mechanism during the deployment process, and as the function of the structure during the deployment and locking stage. Since the 21st century, it has been increasingly adopted by the military field. Based on the tactical requirements of individual radars for rapid withdrawal, off-road marching, rapid erection, and light weight in the war, a soldier radar with an expandable structure consisting of several active linear array antennas arranged uniformly on the circumference to form a cylindrical antenna array is designed. In order to ensure a smooth and reliable deployment of the deployable structure, a link mechanism design with hinge gap is used. According to the corresponding technical requirements,the rigidity of the single-armor radar’s cylindrical box and antenna unit panel was simulated and calculated. The results show that the single-armor radar can meet the technical requirements under the corresponding working conditions without damage.
Optimization Design of an Aircraft Wing Structure based on Response Surface Method
Authors: Hanif A A G , Li H S , Raza M A , Kamran M , Abdullah M 
Published: July 2020

Abstract
Wing is the most critical part of an aircraft whose structural weight holds prime importance. It is always desirable to reduce the weight of an aircraft. In this work, a detailed analysis of wing is carried out and results pertaining to stress distribution are recorded. Commercial software ANSYS is used to perform simulations related to stress, strain and displacement distributions. Moreover, the optimization design of an aircraft wing was conducted using design of experiments (DOE) and response surface method (RSM) technique for the reduction of computational cost. The aircraft wing is efficiently optimized by changing thickness under the same loading and flight conditions. Results show that this optimization technique is useful to reduce stresses as well as overall weight of the structure with minor variation in thickness of components.
Analysis of Gas State in Venus Surface Environment Simulation System
Authors: Wen Gao , Xiaoning Yang , Jing Wang , Qinliang Guo , Boying Lin , Yanqiang Bi , Yue Wu 
Published: July 2020

Abstract
Venus, as a terrestrial planet, not only has the closest distance to Earth in the solar system but also has similar size and mass to Earth, the detection on it has extremely high reference value for Earth and future research. While due to the high temperature, high pressure and weak acid environment on the surface of the planet, the landing detection is hindered. Based on comprehensive analysis and computation on the Venus surface environment simulation process and diffusion state of single-phase binary gas under high-temperature and high-pressure conditions, this article provides an optimization scheme, which would provide support for the establishment of future environmental simulation equipment.
Study on Unlocking Failure Mode for Mechanical Gyroscope in Spacecraft
Authors: Song Xiaohui , Guo Liang , Shan Ming , Zhang Qiang , Wei Lili , Wang Pei , Wang Xiaochen , Feng Tongchun 
Published: July 2020

Abstract
Mechanical gyroscope is a single-degree-of-freedom gyroscope used to measure the angular velocity of the carrier. In this paper, in accordance with the problem in the process of producing, based on the analysis of factors that influence the gyroscope’s assembly& debugging precision, through the experiment and analysis, the cause of in the process of producing is found, the technique to solving the problem is presented. The problem of unable to unlock normally is solved. This technique can be used in the producing of gyroscope and can increase passing rate of mechanical gyroscope. The experimentations result indicate that the scheme is in reason. The efficiency of gyroscope assembly is greatly enhanced.
Thermodynamic Investigation of Conventional and Alternative Rocket Fuels for Aerospace Propulsion
Authors: Ghedjatti Ilyes , Yuan Shiwei , Wang Haixing 
Published: July 2020

Abstract
The magnitude of the exhaust velocity is dependent on molecular and chemical properties of the propellant, and the expansion ratio of the engine. The main requirement for all propellant combinations is to maximize the energy release per kilogram; in other words, the lower the mass for a given energy release, the higher is the ultimate velocity of the vehicle. This also implies that the mass flow rate depends on the density, while the exhaust velocity depends on the energy contained in the hot gas. The main performance parameters can be defined as the thrust coefficient related to the nozzle performance, and the characteristic velocity related to the propellant and combustion performance. The first parameter reaches its optimum when the exhaust pressure is equal to the ambient pressure while the second parameter is defined by the choice of propellant combination. The objective of this work is to investigate, numerically and thermodynamically, different combinations of oxidizers with conventional and alternative fuels, for different rocket propulsion and energy generation systems. Based on the state-of-the-art and the analysis results on the most promising fuel-oxidizer combinations for the future of aerospace propulsion and space transportation, in a technically and environmentally sound manner, conclusions are made.
Dynamic Characteristics Analysis and Flight Test of Free Flight Model with Four Propellers
Authors: Wang Yalong , Yin Wenqiang , Qi Shenjun 
Published: July 2020

Abstract
Flight mode characteristics of free flight model with four propellers are analyzed, based on the results and flight test requirement, the control law is designed, then the simulation model is established and analyzed, finally, the control law is applied to free flight model test.The flight test results show: the propeller promoted the velocity stability and Dutch mode characteristic; level and turn flight stall test subjects were effectively accomplished based on the control law; the dynamic model built can simulate the free flight model test processand initially predict the stall characteristics; level stall angel is 10-12°, turn stall angel is 8-10°.
Research Status and Expectation of Intelligent Deformable Wing Aircraft
Authors: Ma Liangzheng , Huang Wei , Ao Yuntu , Yi Lin , Wang Ying 
Published: July 2020

Abstract
The performance requirements for military reconnaissance, military strikes, long-range transport and medical rescue are constantly increasing. The traditional wing has bottlenecks in terms of improving flight efficiency and mission adaptability, which restrict the performance of the aircraft. With the development of new intelligent materials and continuous pursue of aerodynamic performance, the concept of deformable wing emerges as the times require. This paper analyzes the advantages and disadvantages of deformable wing aircraft, summarizes the research results and current situation at home and abroad, and finally makes a prospect for the development of the technology.
Mechanism of visible-light-driven photocatalytic degradation of endosulfan pesticide by gold nanoparticles
Authors: Goel Puja , Arora Manju 
Published: July 2020

Abstract
Spherical shaped gold nanoparticles (GNPs) of size around ∼9 nm were successfully used for photocatalytic degradation of hazardous endosulfan (ES) pesticide. GNPs absorb sunlight at ambient condition in aqueous medium to enhance localized surface plasmon resonance (LSPR) which initiate hydrolysis, oxidation and reduction chemical reactions for the mineralization of ES molecules. Infrared transmittance spectra of GNPs treated ES solutions revealed formation of amorphous carbon and hydrocarbon as final reaction products indicating the nearly complete mineralization of ES as evidenced from their TEM images also. The disappearance of chloro carbon and sulphite functional groups peaks of ES in IR transmittance spectra confirmed their degradation. TEM images also support the optical absorption spectra consisting of inter-band and LSPR bands pertaining to individual and clustered GNPs ensembles. The redshift in LSPR absorption peak positions along minor and major axis of clustered GNPs ensembles is attributed to the change in GNPs polarizability on interaction with the electric component of visible light. The chemical reaction pathway for ES molecule degradation by the photocatalytic GNPs has been proposed in the light of inferences drawn from TEM images, IR transmittance and optical absorption spectra.
Atomic and close-to-atomic scale manufacturing: perspectives and measures
Authors: Fang Fengzhou 
Published: July 2020

Abstract
This article presents the three paradigms of manufacturing advancement: Manufacturing I, craft-based manufacturing by hand, as in the Stone, Bronze, and Iron Ages, in which
manufacturing precision was at the millimeter scale; Manufacturing II, precision-controllable
manufacturing using machinery whereby the scales of material removal, migration, and addition
were reduced from millimeters to micrometers and even nanometers; and Manufacturing III,
manufacturing objectives and processes are directly focused on atoms, spanning the macro through
the micro- to the nanoscale, whereby manufacturing is based on removal, migration, and
addition at the atomic scale, namely, atomic and close-to-atomic scale manufacturing (ACSM). A
typical characteristic of ACSM is that energy directly impacts the atom to be removed, migrated,
and added. ACSM, as the next generation of manufacturing technology, will be employed to
build atomic-scale features for required functions and performance with the capacity of mass
production. It will be the leading development trend in manufacturing technology and will play a significant role in the manufacture of high-end components and future products.
Synthesis of 2-phenyl-5,6,7,8-tetrahydroquinoxaline derivatives and screening for P2X1-purinoceptor antagonist activity in isolated preparations of rat vas deferens, for translation into a male contraceptive†
Authors: Mathiew Mitch , Dennis Belinda M , Bennetts Felix , Su N N Eunice , Nguyen Nghi , Botteon Antony , Baell Jonathan B , Ventura Sabatino 
Published: July 2020

Abstract
Sympathetically mediated contractions of smooth muscle cells in the vasa deferentia are mediated by neuronally released adenosine 5′-triphosphate (ATP) and noradrenaline, which stimulate P2X1-purinoceptors and α1A-adrenoceptors, respectively. This process is crucial for sperm transport, as demonstrated in knockout mouse studies where simultaneous genetic deletion of P2X1-purinoceptors and α1A-adrenoceptors resulted in male infertility. We hypothesize that dual pharmacological antagonism of these two receptors could inhibit sperm transport sufficiently to provide a novel nonhormonal method of male contraception. To generate a suitable P2X1-purinoceptor antagonist, substituents were introduced on the phenyl moiety of 2-phenyl-5,6,7,8-tetrahydroquinoxaline to create a series of analogues that were tested for P2X1-purinoceptor antagonism in isolated preparations of rat vas deferens. Novel compounds were initially screened for their ability to attenuate contractile responses to electrical field stimulation (EFS: 60 V, 0.5 ms, 0.2 Hz). The addition of polar substituents to the meta, but not ortho, position markedly increased the inhibition of contractions, as did the addition of both polar and aliphatic substituents to the para position. Di-substituted compounds were also synthesized and tested, resulting in a compound 31 (2-hydroxy, 4-fluoro), which exhibited the greatest potency, with an IC50 of 14 μM (95% confidence limits: 12–16 μM). Additionally, compound 31 noncompetitively antagonized contractions mediated by exogenously administered αß-methylene ATP (10 nM–30 μM) but had no inhibitory effect on contractions mediated by exogenously administered noradrenaline (30 nM–100 μM) or acetylcholine (30 nM–100 μM). These results have contributed to a structure–activity relationship profile for the P2X1-purinoceptor that will inform future designs of more potent antagonists.
Chromosome-level de novo assembly of the pig-tailed macaque genome using linked-read sequencing and HiC proximity scaffolding
Authors: Roodgar Morteza , Babveyh Afshin , Nguyen Lan H , Zhou Wenyu , Sinha Rahul , Lee Hayan , Hanks John B , Avula Mohan , Jiang Lihua , Jian Ruiqi , Lee Hoyong , Song Giltae , Chaib Hassan , Weissman Irv L , Batzoglou Serafim , Holmes Susan , Smith David G , Mankowski Joseph L , Prost Stefan , Snyder Michael P 
Published: July 2020

Abstract

Background
Macaque species share &gt;93% genome homology with humans and develop many disease phenotypes similar to those of humans, making them valuable animal models for the study of human diseases (e.g., HIV and neurodegenerative diseases). However, the quality of genome assembly and annotation for several macaque species lags behind the human genome effort.

Results
To close this gap and enhance functional genomics approaches, we used a combination of de novo linked-read assembly and scaffolding using proximity ligation assay (HiC) to assemble the pig-tailed macaque (Macaca nemestrina) genome. This combinatorial method yielded large scaffolds at chromosome level with a scaffold N50 of 127.5 Mb; the 23 largest scaffolds covered 90% of the entire genome. This assembly revealed large-scale rearrangements between pig-tailed macaque chromosomes 7, 12, and 13 and human chromosomes 2, 14, and 15. We subsequently annotated the genome using transcriptome and proteomics data from personalized induced pluripotent stem cells derived from the same animal. Reconstruction of the evolutionary tree using whole-genome annotation and orthologous comparisons among 3 macaque species, human, and mouse genomes revealed extensive homology between human and pig-tailed macaques with regards to both pluripotent stem cell genes and innate immune gene pathways. Our results confirm that rhesus and cynomolgus macaques exhibit a closer evolutionary distance to each other than either species exhibits to humans or pig-tailed macaques.

Conclusions
These findings demonstrate that pig-tailed macaques can serve as an excellent animal model for the study of many human diseases particularly with regards to pluripotency and innate immune pathways.
LncRNA HCG18 contributes to the progression of hepatocellular carcinoma via miR-214-3p/CENPM axis
Authors: Zou Yuepei , Sun Zhonghua , Sun Shuangming 
Published: July 2020

Abstract
Long non-coding RNA (lnc) HCG18 has been reported to contribute progression of a variety of tumours. However, its roles in hepatocellular carcinoma (HCC) remains unknown. In the current study, we intended to uncover the biological functions of HCG18 in HCC. Quantitative real-time polymerase chain reaction (qRT-PCR) was conducted to detect the expression of HCG18, microRNA-214-3p (miR-214-3p) and centromere protein M (CENPM) messenger RNA (mRNA). The role of HCG18 in the growth and migration were assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, colony formation assay, wound healing assay and flow cytometry in vitro and animal experiments in vivo. The results showed that HCG18 was highly expressed in HCC tissues. HCG18 silencing inhibited the proliferation and migration while induced the apoptosis of HCC cells. Besides, miR-214-3p was down-regulated in HCC cells. Further experiments revealed that miR-214-3p could directly bind to HCG18 and exerted an anti-tumour role to counteracted siHCG18-1-mediated influence in HCC cells. Moreover, miR-214-3p could directly interact with CENPM mRNA and down-regulating the expression of CENPM. While HCG18 could up-regulate the expression of CENPM through acting as a sponge of miR-214-3p. Therefore, those results suggested HCG18 functioned as an oncogene to promote the proliferation and migration of HCC cells via miR-214-3p/CENPM axis.
Development of a miniaturized 3D organoid culture platform for ultra-high-throughput screening
Authors: Du Yuhong , Li Xingnan , Niu Qiankun , Mo Xiulei , Qui Min , Ma Tingxuan , Kuo Calvin J , Fu Haian 
Published: July 2020

AbstractThe recent advent of robust methods to grow human tissues as 3D organoids allows us to recapitulate the 3D architecture of tumors in an in vitro setting and offers a new orthogonal approach for drug discovery. However, organoid culturing with extracellular matrix to support 3D architecture has been challenging for high-throughput screening (HTS)-based drug discovery due to technical difficulties. Using genetically engineered human colon organoids as a model system, here we report our effort to miniaturize such 3D organoid culture with extracellular matrix support in high-density plates to enable HTS. We first established organoid culturing in a 384-well plate format and validated its application in a cell viability HTS assay by screening a 2036-compound library. We further miniaturized the 3D organoid culturing in a 1536-well ultra-HTS format and demonstrated its robust performance for large-scale primary compound screening. Our miniaturized organoid culturing method may be adapted to other types of organoids. By leveraging the power of 3D organoid culture in a high-density plate format, we provide a physiologically relevant screening platform to model tumors to accelerate organoid-based research and drug discovery.
A case of missed unstable cervical injury during the COVID-19 pandemic
Authors: Archer James E , Gardner Adrian 
Published: July 2020

Abstract
This case report discusses a patient with a significant, unstable, three-column injury of the cervical spine, which was not initially detected and was subsequently found on reassessment at 2 weeks post injury. The report discusses the imaging findings and the subsequent management of the injury. The report highlights the need for an individualized assessment of each presentation, taking into account the circumstances of injury and any pre-existing degenerative change in the spine.