bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Clean Hands Doctrine as a General Principle of International Law
Authors: Dumberry Patrick 
Published: August 2020

Abstract
The question of the scope and application of the doctrine of clean hands by investment tribunals is controversial. This article examines how scholars, international courts and tribunals and investment tribunals have analysed the concept. I will show that while the doctrine has rarely been used by international tribunals, they have nonetheless recognised and applied the clean hands doctrine in several awards. I will critically assess the reasoning of the Yukos award and, most importantly, the recent South American Silver Limited award, which have both held that the clean hands doctrine is not a general principle of law. I will argue, like many writers, that the doctrine should be considered as a general principle of international law. The article examines this concept and describes how such principles emerge on the international plane in a manner different from general principles grounded in the domestic laws of States.
Amicable Settlements in Investor-State Disputes: Empirical Analysis of Patterns and Perceived Problems
Authors: Ubilava Ana 
Published: August 2020

Abstract
This article empirically analyses investor-State arbitration cases that settle amicably after the arbitration has commenced but before the final award is rendered. The study investigates whether, and to what extent, some common criticisms of amicable settlements are evident in practice. It examines four questions that correspond to the major critiques of amicable settlements in investor-State dispute resolution: (1) Are certain types of investor-State disputes unsuitable to be settled amicably? (2) Do amicable settlements impede transparency? (3) Do amicable settlements pay less compared to when investors win? (4) Is the non-enforceability of settlement agreements a problem in practice? The findings suggest that in practice, not all of these purported problematic aspects of dispute resolution mechanisms that result in amicable settlements are as evident as is commonly believed.
Is an Atheist Religion in Austria Legally Possible?
Authors: Apfalter Wilfried 
Published: September 2020

Abstract
In the face of widespread opinion holding that atheism is somehow necessarily separated from religion and opposed to it, the question “Is an atheist religion in Austria legally possible?” is both intriguing and challenging, leading to the cutting edge of contemporary studies on law, religion, and state. By providing a close, focused view on the legal framework concerning an example case in the Republic of Austria, the present article revisits this widespread opinion. It argues that this opinion can be challenged from a legal point of view in at least one concrete case, namely that of a growing group of atheists who try to establish an officially accepted, state-registered religious denominational community of atheists: Atheistische Religionsgesellschaft in Österreich (Atheist Religious Society in Austria), or arg for short. The article discusses this case and concludes that an atheist religion is legally possible in Austria.
An Event Conflation Model based on the Realization Event
Authors: Kou Xinyan , Hohenstein Jill 
Published: August 2020

Abstract
In this theoretical analysis, we first identify four event components essential to the conceptualization of Realization – manner salience, agentivity, the intended result and the real-world result. We move on to establish an event conflation model which reflects their interplay in an attempt to outline the speech generation mechanisms behind different lexicalization patterns. By offering alternative interpretations for some well-established findings in the Motion domain from the Realization perspective, we also explore the possibility of applying unified analysis to different macro-event types.
Yearning for Recognition: Indigenous Formosans and the Limits of Indigeneity
Authors: Simon Scott 
Published: August 2020

Abstract
Indigeneity, enshrined in the 2007 United Nations Declaration on the Rights of Indigenous Peoples, is an international governance model that promises sovereignty and self-government to indigenous nations. Anthropologists have expressed concern that indigeneity may become an avatar of neoliberal governance that benefits a small elite and contributes to the hypermarginalisation of the poor. This multi-scalar ethnography explores the meaning of indigeneity in Seediq and Truku communities. The author concurs that legal indigeneity fails to meet the needs of the poor. Most ordinary indigenous people perceive that they already benefit from Taiwan’s existing legal framework and fail to understand the need for new institutions. For the case of Taiwan, moreover, the limits of indigeneity are most evident in the exclusion of Taiwanese indigenous peoples—and Taiwan—from United Nations mechanisms. As indigeneity degenerates into great power politics, it falls short of its aspirations to recognise indigenous nations as ontological equals to established states.
Architecture of the World’s Major Religions
Authors: Barrie Thomas 
Published: August 2020

Abstract
In Architecture of the World’s Major Religions: An Essay on Themes, Differences, and Similarities, religious architecture is presented and explained in ways that challenge predominant presumptions regarding its aesthetic, formal, spatial, and scenographic elements. Two positions frame its narrative: religious architecture is an amalgam of aesthetic, social, political, cultural, economic, and doctrinal elements; and these elements are materialized in often very different ways in the world’s principal religions. Central to the essay’s theoretical approaches is the communicative and discursive agency of religious architecture, and the multisensory and ritual spaces it provides to create and deliver content. Subsequently, mythical and scriptural foundations, and symbols of ecclesiastical and political power are of equal interest to formal organizations of thresholds, paths, courts, and centers, and celestial and geometric alignments. Moreover, it is equally concerned with the aesthetic—visual and material cultures and the transcendent realms they were designed to evoke, as it is with the kinesthetic—the dynamic and multisensory experience of place and the tangible experiences of the body’s interactions with architecture.
Mapping Mountains
Authors: Capello Ernesto 
Published: August 2020

Abstract
Mountains appear in the oldest known maps, yet their representation has proven a notoriously difficult challenge for map makers. This essay surveys the broad history of relief representation in cartography with an emphasis on the allegorical, commercial and political uses of mapping mountains. After an initial overview and critique of the traditional historiography and development of techniques of relief representation, the essay features four clusters of mountain mapping emphases. These include visions of mountains as paradise, the mountain as site of colonial and postcolonial encounter, the development of elevation profiles and panoramas, and mountains as mass-marketed touristed itineraries.
Eschatological Awareness without Apocalyptic or Millenarian Expectations: Facing the Future in the Ottonian World (from the 10th to the Early 11th Century)
Authors: Manganaro Stefano 
Published: August 2020

Abstract
This article reconstructs the perception of the future in Ottonian culture by investigating a variety of sources produced within the chronological and geographical framework of the Roman–Germanic Empire (Germany, Italy, and Lotharingia) at the time of Saxon kings and emperors (919–1024). Traditional scholarly interest in end times at the turn of the first millennium is here intertwined with a more recent transdisciplinary perspective that focuses on the notion of contingency. Ottonian sources provide evidence of how a real concern about historical contingencies, which affect this-worldly future events, could coexist with an eschatological awareness that induced patterns of thought and behavior in view of eternal salvation, in connection with the belief that the last age of the world had already begun long ago. This belief, not to be confused with speculations about the imminence of the end, should be properly understood and contextualized, and a clear distinction among eschatology, apocalypticism, and millenarianism is therefore required. Although each Ottonian author had a particular approach toward the future, influenced by various circumstances and different authorial intentions (doctrinal reflection, pastoral responsibilities, devotion, political reasons, rhetorical purposes, and propaganda), the analysis of these sources reveals an appropriation of Augustinian themes and teachings that seems to have been widespread, deep, and genuine. What emerges is a complex picture of how prominent Ottonian authors conceived and coped with the future, passing from the cosmic to existential dimension, from spiritual commitment to ordinary business, and from the uncertainty of terrestrial future to the transcendent certainty of the Last Things.
Overall Impact of the COVID-19 Pandemic on Interventional Radiology Services: A Canadian Perspective
Authors: Patel Neeral R. , El-Karim Ghassan Awad , Mujoomdar Amol , Mafeld Sebastian , Jaberi Arash , Kachura John R. , Tan Kong Teng , Oreopoulos George D. 
Published: August 2020

Purpose: The aim of this national survey was to assess the overall impact of the coronavirus disease 2019 (COVID-19) pandemic on the provision of interventional radiology (IR) services in Canada. Methods: An anonymous electronic survey was distributed via national and regional radiology societies, exploring (1) center information and staffing, (2) acute and on-call IR services, (3) elective IR services, (4) IR clinics, (5) multidisciplinary rounds, (6) IR training, (7) personal protection equipment (PPE), and departmental logistics. Results: Individual responses were received from 142 interventional radiologists across Canada (estimated 70% response rate). Nearly half of the participants (49.3%) reported an overall decrease in demand for acute IR services; on-call services were maintained at centers that routinely provide these services (99%). The majority of respondents (73.2%) were performing inpatient IR procedures at the bedside where possible. Most participants (88%) reported an overall decrease in elective IR services. Interventional radiology clinics and multidisciplinary rounds were predominately transitioned to virtual platforms. The vast majority of participants (93.7%) reported their center had disseminated an IR specific PPE policy; 73% reported a decrease in case volume for trainees by at least 25% and a proportion of trainees will either have a delay in starting their careers as IR attendings (24%) or fellowship training (35%). Conclusion: The COVID-19 pandemic has had a profound impact on IR services in Canada, particularly for elective cases. Many centers have utilized virtual platforms to provide multidisciplinary meetings, IR clinics, and training. Guidelines should be followed to ensure patient and staff safety while resuming IR services.
No rest for elderly femur fracture patients: early surgery and early ambulation decrease mortality
Authors: Aprato Alessandro , Bechis Marco , Buzzone Marco , Bistolfi Alessandro , Daghino Walter , Massè Alessandro 
Published: August 2020

Abstract
Background
Literature has shown a significant correlation between early treatment and mortality in femur fractures, but the influence of time to ambulation on mortality has not been studied. The purpose of the present study is to evaluate whether time to ambulation is correlated to femur fracture mortality independently from time to surgery.

Patients and methods
All patients older than 65 years admitted at a level I trauma center with proximal femoral fracture during a 1-year period were included. The following data were collected: age, gender, date and time of admission to emergency department, height, weight, body mass index, type and side of fracture, ASA score, date and time of surgery, surgical time, time to ambulation, length of hospitalization, death during hospitalization, and mortality at 6 and 12 months.

Results
The study sample comprises 516 patients. The mean age was 83.6 years; ASA score was 3–5 in 53% of patients; 42.7% presented with medial fracture; mean time between admission and surgery was 48.4 h; 22.7% of patients were not able to walk during the first 10 days after fracture; mean duration of hospitalization was 13 days; and mortality was 17% at 6 months and 25% at 1 year. Early surgery and walking ability at 10 days after trauma were independently and significantly associated with mortality at 6 months (p = 0.014 and 0.002, respectively) and at 1 year (0.027 and 0.009, respectively).

Conclusions
Early surgery in femur fracture became a priority in health systems, but early postoperative physiotherapy also plays a major role in prevention of mortality: independently from surgical timing, patients who did not walk again within 10 days from surgery showed mortality rates higher than those of patients who did.

Level of evidence
IV.
The genetic basis of diurnal preference in Drosophila melanogaster
Authors: Pegoraro Mirko , Flavell Laura M. M. , Menegazzi Pamela , Colombi Perrine , Dao Pauline , Helfrich-Förster Charlotte , Tauber Eran 
Published: August 2020

Abstract
Background
Most animals restrict their activity to a specific part of the day, being diurnal, nocturnal or crepuscular. The genetic basis underlying diurnal preference is largely unknown. Under laboratory conditions, Drosophila melanogaster is crepuscular, showing a bi-modal activity profile. However, a survey of strains derived from wild populations indicated that high variability among individuals exists, including flies that are nocturnal.

Results
Using a highly diverse population, we performed an artificial selection experiment, selecting flies with extreme diurnal or nocturnal preference. After 10 generations, we obtained highly diurnal and nocturnal strains. We used whole-genome expression analysis to identify differentially expressed genes in diurnal, nocturnal and crepuscular (control) flies. Other than one circadian clock gene (pdp1), most differentially expressed genes were associated with either clock output (pdf, to) or input (Rh3, Rh2, msn). This finding was congruent with behavioural experiments indicating that both light masking and the circadian pacemaker are involved in driving nocturnality.

Conclusions
Our study demonstrates that genetic variation segregating in wild populations contributes to substantial variation in diurnal preference. We identified candidate genes associated with diurnality/nocturnality, while data emerging from our expression analysis and behavioural experiments suggest that both clock and clock-independent pathways are involved in shaping diurnal preference. The diurnal and nocturnal selection strains provide us with a unique opportunity to understand the genetic architecture of diurnal preference.
A multi-center naturalistic study of a newly designed 12-sessions group psychoeducation program for patients with bipolar disorder and their caregivers
Authors: Zyto Susan , Jabben Nienke , Schulte Peter F. J. , Regeer Eline J. , Goossens Peter J. J. , Kupka Ralph W. ,   the Task Force Psychotherapy of the Dutch Foundation for Bipolar Disorders
Published: September 2020

Abstract
Background
Psychoeducation (PE) for bipolar disorder (BD) has a first-line recommendation for the maintenance treatment phase of BD. Formats vary greatly in the number of sessions, whether offered individually or in a group, and with or without caregivers attending. Due to a large variation in formats in the Netherlands, a new program was developed and implemented in 17 outpatient clinics throughout the country. The current study investigated the feasibility of a newly developed 12-sessions PE group program for patients with BD and their caregivers in routine outpatient practice and additionally explored its effectiveness.

Methods
Participants in the study were 108 patients diagnosed with BD, 88 caregivers and 35 course leaders. Feasibility and acceptance of the program were investigated by measures of attendance, and evaluative questionnaires after session 12. Preliminary treatment effects were investigated by pre- and post-measures on mood symptoms, attitudes towards BD and its treatment, levels of self-management, and levels of expressed emotion.

Results
There was a high degree of satisfaction with the current program as reported by patients, caregivers, and course leaders. The average attendance was high and 83% of the patients and 75% of the caregivers completed the program. Analyses of treatment effects suggest positive effects on depressive symptoms and self-management in patients, and lower EE as experienced by caregivers.

Conclusions
This compact 12-sessions psychoeducation group program showed good feasibility and was well accepted by patients, caregivers, and course leaders. Preliminary effects on measures of self-management, expressed emotions, and depressive symptoms were promising. After its introduction it has been widely implemented in mental health institutions throughout the Netherlands.
Herd-level risk factors for chronic pleurisy in finishing pigs: a case-control study
Authors: Hälli Outi , Haimi-Hakala Minna , Oliviero Claudio , Heinonen Mari 
Published: September 2020

Abstract
Background
Chronic pleurisy is a common finding in slaughtered pigs in post-mortem meat inspection. The prevalence of pleurisy has been increasing during the last decade also in Finland. The aim of this prospective case-control study was to search for environmental, infectious and management-related herd-level risk factors for pleurisy in the slaughterhouse. Altogether 46 Finnish pig herds, including 25 control (low pleurisy prevalence in meat inspection) and 21 case (high pleurisy) herds, were enrolled in the study and visited during the tenth week of the rearing period of finishing pigs. Herd personnel were asked about basic herd information, management and environmental factors. Selected pigs were examined clinically, environmental parameters were measured and 15 blood samples per herd were taken during herd visits. Antibodies against Actinobacillus pleuropneumonia serotype 2 (APP2) and ApxIV toxin and swine influenza virus were measured. After the slaughter of study pigs, meat inspection results of the batch were gathered from slaughterhouses. Multivariate logistic regression model was built to identify possible risk factors for a herd to be a case herd (i.e. having high pleurisy values).

Results
Finishing herd type and herd size were observed to act as risk factors. None of clinical signs of pigs, management-related factors or environmental measurements were associated with herd status.

Conclusions
As previously known, in endemic and subclinical infections such as APP, herd factors are important, but detailed risk factors seem to be difficult to identify.
Stem extract of Albizia richardiana exhibits potent antioxidant, cytotoxic, antimicrobial, anti-inflammatory and thrombolytic effects through in vitro approach
Authors: Islam Mohammad Nazmul , Tasnim Homyra , Arshad Laiba , Haque Md. Areeful , Tareq Syed Mohammed , Kamal A. T. M. Mostafa , Rahman Md. Masudur , Reza A S. M. Ali , Chowdhury Kazi Ashfak Ahmed , Tareq Abu Montakim 
Published: September 2020

AbstractBackgroundAlbizia richardianabelongs Fabaceae family which different parts like fruits, flowers, barks, and roots are used medicinally. The study reports the in vitro anti-inflammatory, thrombolytic, cytotoxicity and antimicrobial activity of methanolic extract ofA. richardianastem and its different fractions.MethodThe methanolic extract ofA. richardianastem (MEAR) extracted with n-hexane (HXFAR), carbon tetrachloride (CTFAR), chloroform (CFAR), and aqueous (AQFAR) and subjected for DPPH scavenging activity and total phenol content (TPC). The cytotoxic activity evaluated by brine shrimp lethality bioassay, while the disk diffusion method used for the antimicrobial study. The anti-inflammatory and thrombolytic activities of the extracts evaluated by the hypotonic solution induced hemolysis, heat-induced hemolysis and human blood clot lysis, respectively.ResultsAll the extracts exhibited excellent antioxidant activity in the DPPH scavenging assay and maximum total phenol content observed by HXFAR. Secondly, the extract showed a moderate LC50value in brine shrimp lethality bioassay, where the CTFAR extract exhibited potential antimicrobial activities against sixteen different microorganisms. In anti-inflammatory, all the extract exhibited a significant (P < 0.0001) protection against lysis of human erythrocyte membrane induced by heat and hypotonic solution, as compared to the standard acetyl salicylic acid. An extremely significant (P < 0.0001) clot lysis was found in MEAR (16.66%) while the standard drug streptokinase (70.94%).ConclusionAll the fractions revealed the significant free radical scavenging activity. Moreover, CTFAR showed wide spectrum of antimicrobial activity. Thus, the results of the present study provided scientific evidence for the use ofAlbizia richardianaas traditional medicine.
Impact of tumor necrosis factor inhibitors and methotrexate on diabetes mellitus among patients with inflammatory arthritis
Authors: Mantravadi Santhi , George Michael , Brensinger Colleen , Du Min , Baker Joshua F. , Ogdie Alexis 
Published: September 2020

Abstract
Background
To determine whether initiation of a tumor necrosis factor inhibitor (TNFi) or methotrexate improves hemoglobin A1c in patients with psoriatic arthritis (PsA), rheumatoid arthritis (RA), or ankylosing spondylitis (AS) who also have diabetes mellitus (DM).

Methods
A retrospective cohort study was conducted in Optum’s de-identified Clinformatics® Data Mart Database, an administrative claims database, using data from 2000 to 2014. Patients with PsA, RA, or AS, with DM (defined by ICD-9-CM codes) and/or HbA1c ≥7%, who newly initiated either a TNFi, MTX, or metformin (positive control) were identified. The change in HbA1c after drug initiation was calculated. Statistical differences in the change in HbA1c between drugs were assessed using the Wilcoxon rank sum test and linear regression models adjusting for potential confounders.

Results
Among 10,389 drug initiations in 9541 patients with PsA, RA, or AS, and available HbA1c values, HbA1c was ≥7 at baseline in 254 (35%) TNFi initiations, 361(37%) MTX initiations, and 2144 (50%) metformin initiations. Median HbA1c change was − 0.35 (IQR -1.10, 0.30) after TNFi initiation, − 0.40 (IQR -1.20, 0.30) after MTX initiation, and − 0.80 (IQR -1.60, − 0.10) after metformin initiation. In adjusted analyses, TNFi initiators had less of a decrease in HbA1c compared to MTX initiators (β 0.22, 95% CI: 0.004, 0.43), p = 0.046. Metformin initiators had a significantly greater decrease in HbA1c than MTX, β − 0.38 (95% CI: − 0.52, − 0.23), p < 0.001. Glucocorticoid use was not accounted for in the models.

Conclusion
HbA1c decreased with TNFi initiation or MTX initiation. Reductions in HbA1c after initiation of a TNFi or MTX are about half (~ 0.4 units) the decrease observed after initiation of metformin.