bluuebunny/crossref_metadata_2025_split huggingface dataset:
Muc5b-deficient mice develop early histological lung abnormalities
Authors: Valque Hélène , Gouyer Valérie , Duez Catherine , Leboeuf Christophe , Marquillies Philippe , Le Bert Marc , Plet Ségolène , Ryffel Bernhard , Janin Anne , Gottrand Frédéric , Desseyn Jean-Luc 
Published: November 2019

ABSTRACT
Gel-forming mucins are the main organic component responsible for physical properties of the mucus hydrogels. While numerous biological functions of these mucins are well documented, specific physiological functions of each mucin are largely unknown. To investigate in vivo functions of the gel-forming mucin Muc5b, which is one of the major secreted airway mucins, along with Muc5ac, we generated mice in which Muc5b was disrupted and maintained in the absence of environmental stress. Adult Muc5b-deficient mice displayed bronchial hyperplasia and metaplasia, interstitial thickening, alveolar collapse, immune cell infiltrates, fragmented and disorganized elastin fibers and collagen deposits that were, for approximately one-fifth of the mice, associated with altered pulmonary function leading to respiratory failure. These lung abnormalities start early in life, as demonstrated in one-quarter of 2-day-old Muc5b-deficient pups. Thus, the mouse mucin Muc5b is essential for maintaining normal lung function.
The performance of bovine serum albumin filtration by using polyethersulfone-Tetronic 304 blend Ultrafiltration Membrane
Authors: Razi Fachrul , Mulyati Sri , Arahman Nasrul 
Published: November 2019

Background: Membrane technology has been widely applied for protein purification. In applications for protein separation, a membrane with stable filtration performance is necessary. In this work, two types of hollow fiber membranes with different characteristic were used to study the filtration profile of bovine serum albumin. Methods: A single piece of hollow fiber module was used for ultrafiltration testing using UF0 and UFT304 membranes. Flux and rejection of BSA solution were collected based on a pressure-driven inside filtration model. Results: Ultrafiltration experiments showed that the flux of UFT304 membrane was higher than that of UF0 membrane in all applied pressure condition. Solute rejection reaches 90 and 88% for ultrafiltration of BSA solution on the operating pressure of 0.5 atm using UF0 and UFT304 membranes, respectively. Conclusion: In general, UFT304 membranes has better ultrafiltration performance for BSA separation than UF0 membranes. The UFT304 membrane has a more stable flux for up to two hours of filtration.
Urine cytological examination: an appropriate method that can be used to detect a wide range of urinary abnormalities
Authors: Siddig Emmanuel Edwar , Mohamed Nouh S. , Ali Eman Taha , Mohamed Mona A. , Muneer Mohamed S. , Munir Abdulla , Edris Ali Mahmoud Mohammed , Ahmed Eiman S. , Elnour Lubna S. , Hassan Rowa 
Published: November 2019

Background:Urine cytology is a method that can be used for the primary detection of urothelial carcinoma, as well as other diseases related to the urinary system, including hematuria and infectious agents. In this study we aimed at investigating urine abnormalities among Sudanese patients attending Omdurman teaching hospital.Methods:A descriptive cross-sectional study was conducted from November 2016 to October 2017. A voided urine samples were collected and stained using Papanicolaou stain.Results:A total of 1238 urine samples were meticulously examined, 832 (67.2%) from males (mean age 41.7±12.67), and 406 (32.8%) from females (mean age 43.8±10.94). 147 (11.9%) patients had an underlying medical condition, either AIDs, diabetes mellitus type 2 or historical renal transplantation. Hematuria was more frequent amongst males than females, 100 (68.9%) and 45 (31.1%), respectively. Urine cytology diagnosis was 43 cases (3.5%) of candidiasis, 36 cases (2.9%) of reactive urothelial cells, 11 cases (0.9%) of cryptococcosis, 9 cases (0.7%) of urothelial carcinoma, 9 (0.7%) human papilloma virus (HPV) diagnoses, 8 (0.6%) polyomavirus (BKV) diagnoses, 6 (0.5%) schistosomiasis diagnoses and 3 cases (0.2%) of low grade urothelial cells.Conclusion:Urine cytology seems to be a non-invasive technique that is suitable for all patients with urinary tract infections; those with diabetes, renal transplants, and HIV; and patients with macroscopic or microscopic hematuria for the detection of infectious agents and malignancy.
Falco: high-speed FastQC emulation for quality control of sequencing data
Authors: de Sena Brandine Guilherme , Smith Andrew D. 
Published: November 2019

Quality control is an essential first step in sequencing data analysis, and software tools for quality control are deeply entrenched in standard pipelines at most sequencing centers. Although the associated computations are straightforward, in many settings the total computing effort required for quality control is appreciable and warrants optimization. We present falco, an emulation of the popular FastQC tool that runs on average three times faster while generating equivalent results. Compared to FastQC, falco also provides greater scalability for datasets with longer reads and more flexible visualization of HTML reports.
Relatos, memorias y ficcionalizaciones en el arte: Memoria del horror: Las brutas, de Juan Radrigán; Hans Pozo, de Luis Barrales; e Hilda Peña, de Isidora Stevenson
Authors: Rojo Sara 
Published: November 2019

Este trabajo se centrará en tres obras dramáticas chilenas: Las brutas (1980), de Juan Radrigán; Hans Pozo, de Luis Barrales; e Hilda Peña, de Isidora Stevenson. En las tres se retorna a hechos reales: El suicidio de tres mujeres de la etnia Colla, el descuartizamiento de Hans Pozo y el tiroteo tras el asalto al Banco O’Higgins perpetuado por el Movimiento Juvenil Lautaro. Estos hechos son teatralizados y, para ello, se recurre a la memoria colectiva, ala imaginación y a los contextos sociales de enunciación. Son relatos delirantes escritos en la variante popular de los personajes protagonistas, que transitan entre lo real y lo ficcional. El horror se instaura a partir del relato de la vivencia de esas tres mujeres colla, de las voces de los sujetos involucrados en la vida del descuartizado y de la voz de la madre de uno de los muertos en el tiroteo en Hilda Peña.
Existence for (p,q) critical systems in the Heisenberg group
Authors: Pucci Patrizia , Temperini Letizia 
Published: November 2019

AbstractThis paper deals with the existence of entire nontrivial solutions for critical quasilinear systems (𝓢) in the Heisenberg group ℍn, driven by general (p,q) elliptic operators of Marcellini types. The study of (𝓢) requires relevant topics of nonlinear functional analysis because of the lack of compactness. The key step in the existence proof is the concentration–compactness principle of Lions, here proved for the first time in the vectorial Heisenberg context. Finally, the constructed solution has both components nontrivial and the results extend to the Heisenberg group previous theorems on quasilinear (p,q) systems.
Komponisten, Interpreten und Editoren debattieren über Notation
Authors: Schmidt Dörte 
Published: November 2019

Abstract
The article discusses how new developments in the notation of contemporary music were negotiated within the framework of the Darmstadt Summer Courses and which interests and actors played a role in this. The first part examines the publications and publication projects that emerged in the context of the Notation conference in 1964. The focus is on the interests of institutions such as the International Music Council and the International Association of Music Libraries, in whose name the New York publisher Kurt Stone attempted to persuade the International Music Institute Darmstadt to cooperate and, following on from the debates there, to systematically record various forms of notation together. In a second step, the content of the debates at the conference is examined, with a particular focus on the different and sometimes conflicting perspectives of interpreters and composers. Numerous connections to fundamental aesthetic discussions of the time can be worked out, in particular to the relationship between the composer’s intention and interpretation, which was renegotiated in a form of notation that was individualized to the extreme. Finally, with a view to later discussions, this topic is pointed to the question of the relationship between morphology and musical structure, exemplified by positions of Wolfgang Rihm (1982), Klaus Huber (1988) and John Cage (1990).
Lemann Index for Assessment of Crohn’s Disease: Correlation with the Quality of Life, Endoscopic Disease activity, Magnetic Resonance Index of Activity and C- Reactive Protein
Authors: Straksyte Vestina , Kiudelis Gediminas , Gineikiene Irina , Janciauskas Dainius , Basevicius Algidas , Lukosevicius Saulius , Kupcinskas Limas 
Published: November 2019

Abstract

Aim
Crohn’s disease (CD) is characterized by continuing inflammation and progressive gut damage. Despite many scoring indices of CD, there is a lack of more global assessment tools for the evaluation of the total disease impact on the gut.

Methods
Fift y-three adult patients with proven CD underwent magnetic resonance enterocolonography (MR-EC), colonoscopy, and clinical activity assessment, including CRP. Quality of life was assessed using IBDQ. MR-EC was used to evaluate the Magnetic Resonance Index of Activity (MaRIA- global (G)) and the Lemann Index (LI). The CD Endoscopic Index of Severity (CDEIS) was used to score the endoscopic activity of the disease.

Results
A signifi cant correlation between the LI and IBDQ was found (r=-0.812, P<0.01). LI and MaRIA-G correlated moderately, while the LI did not correlate significantly with CRP and CDEIS. For the detection of endoscopically active CD, MaRIA-G was more sensitive and specific (83.3%; 73.3%) compared to the LI (66.7%; 60.0%). There was a moderate correlation between CRP and MaRIA-G, as well as CRP and CDEIS (r=0.496; r=0.527,<0.01).

Conclusion
A signifi cant negative correlation between the LI and quality of life, measured by IBDQ, was found in our study, suggesting that the LI could resemble more global features of the disease, besides inflammatory activity of the gut.
Belastungserleben und sekundäre Viktimisierung durch Missbrauch und Misshandlung in kirchlichen Institutionen
Authors: Prues Andrea , Hoffmann Anika , Rettenberger Martin 
Published: November 2019

Zusammenfassung
Das Bekanntwerden von Missbrauchsvorfällen in pädagogischen Institutionen, auch der katholischen Kirche, löste 2010 eine bundesweite öffentliche Debatte über die Gefahren sexualisierter Gewalt und körperlicher Misshandlungen im institutionellen Kontext aus. Vor diesem Hintergrund befasst sich der vorliegende Beitrag mit der psychologischen Betrachtung von Belastungserleben und dem Prozess der sekundären Viktimisierung bei Fällen des Missbrauchs im institutionellen Kontext. Am Beispiel einer Querschnittsstudie mit 21 ehemaligen Internatsschülern der Regensburger Domspatzen werden die Schwere der traumatischen Kindheitserfahrung, der Zusammenhang mit akuten psychischen Belastungen von Betroffenen und der Einfluss des Umgangs der katholischen Kirche mit der Thematik beleuchtet. Die Erlebnisse der Vergangenheit sowie das aktuelle Erleben der Studienteilnehmer, insbesondere im Hinblick auf den aktuellen Umgang der Kirche mit den Missbrauchsvorwürfen, wurden anhand standardisierter und psychometrisch geprüfter Verfahren erfasst und die Ergebnisse mit denen anderer Stichproben verglichen und umfassend diskutiert.
Applications of polymer-based nanoparticles in vaccine field
Authors: Guo Sihan , Fu Dongwei , Utupova Assem , Sun Dejun , Zhou Mo , Jin Zheng , Zhao Kai 
Published: November 2019

AbstractPolymer-based nanoparticles have good solubility, stability, safety, and sustained release,which increases the absorption of loaded drugs, protects the drugs from degradation, and prolongs their circulation time and targeted delivery. Generally, we believe that prevention and control of infectious diseases through inoculation is the most efficient measure. However, these vaccines including live attenuated vaccines, inactivated vaccines, protein subunit vaccines, recombinant subunit vaccines, synthetic peptide vaccines and DNA vaccines have several defects, such as immune tolerance, poor immunogenicity, low expression level and induction of respiration pathological changes. All kinds of biodegradable natural and synthetic polymers play major roles in the vaccine delivery system to control the release of antigens for an extended period of time. In addition, these polymers also serve as adjuvants to enhance the immunogenicity of vaccine. This review mainly introduces natural and synthetic polymer-based nanoparticles and their formulation and properties. Moreover, polymer-based nanoparticles as adjuvants and delivery carriers in the applications of vaccine are also discussed. This review provides the basis for further operation of nano vaccines by utilizing the polymer-based nanoparticles as vaccine adjuvants and delivery systems. Polymer-based nanoparticles have exhibited great potential in improving the immunogenicity of antigens and the development of nano vaccines in future.
Experimental study on the existence of nano-scale pores and the evolution of organic matter in organic-rich shale
Authors: Yu Weiming , Tang Hongming 
Published: November 2019

Abstract
To explore the characteristics of nanopores in organic-rich shale, the shale of the Upper Yangtze area under different maturity are studied. Scanning electron microscopy (SEM), low temperature nitrogen experiment (LP-N2-GA) and the Frenkel-Halsey-Hill (FHH) fractal model were used. Results show that the intergranular pores and organic pores are most developed, and the pore size is distributed from a few nanometers to several tens of micrometers. The SEM gray scale images make the pore development characteristics of shale be observed more intuitively. Based on the results of low temperature nitrogen adsorption test and FHH fractal model, the results show the fractal dimension of shale is positively correlated with TOC and quartz, but negatively related to clay minerals and feldspar. There is a good relation between maturity and pore volume.With releasing of pressure, the pore evolution gradually returns to the normal compaction trend, and the pore volume of the shale decrease.

Graphical abstract: There are many nano-scale pores in the shale, and the pore characteristics determine the characteristics of shale reservoirs. At the initial stage of sedimentary burial, when Ro is less than 0.7%, the pore volume and specific surface area of the initial shale are large. At the medium maturity stage (0.7%<Ro<1.3%), the pore volume and pores caused by mechanical compaction to some extent. As the degree of thermal evolution deepens to the high maturity stage (1.3% <Ro < 2.6%), the shale is generating large amount of gas. The shale belongs to the low-porosity and low-permeability reservoirs, and the generated oil and gas cannot be effectively transported in a short period of time. The overpressure of the reservoir and the inter-mineral pore characteristics caused by the organic pores and organic acids formed by the hydrocarbon generation are more complicated. When shale is in the stage of over-maturation (Ro>2.6%), as the increase of buried depth, the end of hydrocarbon generation process and long-term pressure release, the under-compacting effect gradually disappear. Porosity evolution gradually returns to normal compaction trend in the shale.
Das Uschebti H 219 im Badischen Landesmuseum und die Chronologie der memphitischen Bürgermeister der 19. Dynastie
Authors: Herzberg-Beiersdorf Anne 
Published: November 2019

Summary
The inventory number H 219 of the Badisches Landesmuseum Karlsruhe contains the faience shabti of a Memphitic mayor. These civil rulers, subordinate to the king, are mainly responsible for the administration and organisation of the city and its subordinate area, whereby they form the highest regional-administrative instance. Although the Karlsruhe shabti has already been published, its owner has not yet been brought into contact with the circle of Memphite mayors. The aim of this article is to rearrange the chronological order of the known Ramesside officials and to position the owner of the Karlsruhe shabti within this group.
Not a Babe, Certainly not a Mouth
Authors: Klotz David 
Published: November 2019

Summary
Response to “Out of the Mouths of Babes” by Benjamin Hinson (ZÄS 144/1). The alleged word for “child” is based on an erroneous reading. Parallels show this is a very different epithet (“he who ejaculates the Nun waters”), most likely denoting Atum.
The Ritual of “Encircling the Tomb” in the Funerary Monument of Djehuty (TT 11)
Authors: Serrano José M. 
Published: November 2019

Summary
In the Theban tomb of Djehuty (TT 11) we have the representation of a ritual apparently focused on surrounding the funerary monument. The objective of this paper is the reconstruction of the scene, and the text that accompanies it, thanks to the parallel of TT 20 (Montuherkhepeshef). This allows us to link this ritual to the Pap. Ramesseum E and other antecedents of the Old and Middle Kingdom. An interpretation within the historical, religious and cultural context of the age of Hatshepsut-Thutmose III, and a possible relationship with the Middle Egypt background of the owners of TT 11 and TT 20 is also proposed.
MicroRNAs Regulate Multiple Aspects of Locomotor Behavior inDrosophila
Authors: Donelson Nathan C , Dixit Richa , Pichardo-Casas Israel , Chiu Eva Y , Ohman Robert T , Slawson Justin B , Klein Mason , Fulga Tudor A , Van Vactor David , Griffith Leslie C 
Published: November 2019

AbstractLocomotion is an ancient and fundamental output of the nervous system required for animals to perform many other complex behaviors. Although the formation of motor circuits is known to be under developmental control of transcriptional mechanisms that define the fates and connectivity of the many neurons, glia and muscle constituents of these circuits, relatively little is known about the role of post-transcriptional regulation of locomotor behavior. MicroRNAs have emerged as a potentially rich source of modulators for neural development and function. In order to define the microRNAs required for normal locomotion in Drosophila melanogaster, we utilized a set of transgenic Gal4-dependent competitive inhibitors (microRNA sponges, or miR-SPs) to functionally assess ca. 140 high-confidence Drosophila microRNAs using automated quantitative movement tracking systems followed by multiparametric analysis. Using ubiquitous expression of miR-SP constructs, we identified a large number of microRNAs that modulate aspects of normal baseline adult locomotion. Addition of temperature-dependent Gal80 to identify microRNAs that act during adulthood revealed that the majority of these microRNAs play developmental roles. Comparison of ubiquitous and neural-specific miR-SP expression suggests that most of these microRNAs function within the nervous system. Parallel analyses of spontaneous locomotion in adults and in larvae also reveal that very few of the microRNAs required in the adult overlap with those that control the behavior of larval motor circuits. These screens suggest that a rich regulatory landscape underlies the formation and function of motor circuits and that many of these mechanisms are stage and/or parameter-specific.
Молодежные бренды одежды как агенты социализации
Authors: Калуга Марина Сергеевна 
Published: November 2019

<p>В статье рассматриваются молодежные бренды одежды H&amp;M, United colors of Benetton, Zara как агенты социализации; на основе качественного анализа контента социальных кампаний названных брендов выделены социальные ценности и нормы, транслируемые ими.</p>
De la tarta de manzanas a la estética business-pop
Authors: Finquelievich Susana 
Published: November 2019

Desde una óptica que focaliza la revolución tecnológica como eje del cambio acelerado de las bases materiales de la sociedad, la autora sitúa los sistemas de red como un factor que acrecienta la complejidad de la interacción social emergentes del poder creativo de las lógicas propias de la red. Enfatiza sobre la circulación de flujos de información, que conforman un nuevo espacio de prácticas sociales, afectando el poder, las instituciones y los medios de comunicación. A partir de este esquema, la autora analiza el alcance de la tecnología como un factor no determinante de la sociedad. Focaliza a la revolución tecnológica en el orden metodológico y a éste, a su vez, en la determinación de factores exógenos país, momento histórico, cultura- respecto de los resultados de su impacto. En un diagnóstico que define a la red como la forma virtual y simbólica por excelencia, el análisis enlaza el eje cartesiano con la cultura, los sujetos y las nuevas formas de producción de objetos culturales.
Association between NMD3 and symptoms of Parkinson's disease in Chinese
Authors: Wu Hui , Li Hui , Shi Zhiqiang , Tang Jiajia , Mei Shuya , Ai Tianyi , He Zhenzhou 
Published: November 2019

Abstract
Bcakground: Parkinson's disease (PD) is a progresasive neurodegenerative movement disorder which is characterized by motor symptoms such as tremor, rigidity, slowness of movement and problems with gait. Large-scale meta-analyses of genome-wide association studies (GWAS) have identified few susceptibility loci in sporadic PD. The aim of this study was to investigate the association between NMD3 single nucleotide polymorphism (SNP) and symptoms of PD patients in southern Chinese. Methods: A total of 217 PD patients were recruited in this study and were genotyped by using SNaPshot technique and the polymer chain reaction. All subjects were evaluated by Mini-Mental State Examination (MMSE), Beijing version Montreal Cognitive Assessment (MoCA), Sniffin’ Sticks 16 (SS-16), Hamilton anxiety rating scale, Hamilton depression rating scale, 39-item Parkinson's disease Questionnaire (PDQ-39) and MDS Unified PD Rating Scale (MDS-UPDRS). Results: NMD3 rs34016896 (T) carriers have worse cognitive function (MMSE: p 0.042, NMD3wildtype: 27.44 ± 2.89, NMD3 carriers: 26.31 ± 3.79; MoCA: p 0.005, NMD3 wildtype: 23.15 ±4.20, NMD3 carriers: 20.75 ± 6.68). Conclusions: The recessive and overdominant model of NMD3 rs34016896 was associated with cognitive impairment in PD patients.