bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute pain management in patients with opiate maintenance treatment in primary care: a qualitative study
Authors: landreat morgane guillou , Baillot Melia , Delphine Le Goff , Yves Le Reste Jean 
Published: February 2020

Abstract
Background: Opiate use disorders are a worldwide disease. In the last 30 years, opiate maintenance treatment prescription changed patients’ and also changed physicians’ practice. General practitioners (GPs) have to deal with patients on OMT who are in acute pain. Both clinically and pharmacologically, the treatment of acute pain in patients with an opiate use disorder and an OMT(opiate maintenance treatment) differs from that given to patients with other conditions. As this situation is complex, it was important to explore whether GPs recognised this problem and whether they managed it effectively.Objective: To investigate how GPs identify and manage situations of acute pain in patients with opiate use disorders and OMT. Methods: semi-structured interviews were used as a data collection technique with a purposive sample of practising GPs. Data collection continued until saturation was reached. Analysis was undertaken using a thematic analysis method. Two independent researchers, working blind and pooling data, carried out the analysis. Results: The maximal variation of the sample and saturation of data were reached with 11 GPs. The thematic analysis resulted in 4 main themes: (1) the importance and difficulties of professional links , (2) the specific clinical reasoning , (3) the importance of the doctor-patient relationship and (4) the particular characteristics of OMT patients. Conclusion: The complexity of pain and opioid dependence represents significant challenges for GPs. It is hard to achieve a balance between pain relief and opiate use disorder treatment. These questions are particularly important in general practice, where the practitioner may feel insufficiently trained, and isolated. Existing protocols do not seem to be in line with general practice. The number of patients on OMT has increased since it was first marketed; GPs will increasingly have to deal with these situations and will have to issue their own recommendations.
Patient’s travel distance to specialised cancer diagnostics and the association with the general practitioner’s diagnostic strategy and satisfaction with the access to diagnostic procedures: an observational study in Denmark
Authors: Virgilsen Line Flytkjær , Hvidberg Line , Vedsted Peter 
Published: February 2020

Abstract
Background: Patients with cancer often consult their general practitioner (GP) prior to the diagnosis. Thus, actions taken by the GP are crucial for optimisation of cancer care. This study aimed to investigate the association between cancer patient’s travel distance to the first specialised diagnostic investigation and the GP’s diagnostic strategy and satisfaction with the waiting time and the availability of diagnostic investigations.Method: This combined questionnaire- and registry-based study included incident cancer patients diagnosed in the last six months of 2016 where the GP had been involved in the diagnostic process of the patients prior to their diagnosis of cancer (n=3,455). The patient’s travel distance to the first specialised diagnostic investigation was calculated by ArcGIS Network Analyst. The diagnostic strategy of the GP and the GP’s satisfaction with the waiting times and the available investigations were assessed from GP questionnaires. Results: The patient’s travel distance to the first specialised diagnostic investigation was not associated with the diagnostic strategy of the GP. However, when the GP did not suspect cancer or serious illness, a tendency was seen that longer travel distance to the first specialised diagnostic investigation increased the likelihood of the GP using ’wait-and-see’ approach and ’medical treatment’ as diagnostic strategies. The GPs of patients with travel distance longer than 49 kilometres to the first specialised diagnostic investigation were more likely to report dissatisfaction with the waiting time for requested diagnostic investigations (PRR: 1.98, 95% CI: 1.20-3.28).Conclusion: A tendency to use ‘wait-and-see’ and ‘medical treatment’ were more likely in GPs of patients with long travel distance to the first diagnostic investigation when the GP did not suspect cancer or serious illness. Long distance was associated with higher probability of GP dissatisfaction with the waiting time for diagnostic investigations.
Developing an E-Platform for Monitoring Wellbeing in Schools: Involving Young People in Setting the Research Agenda.
Authors: Grant Claire Ellen , Widnall Emily , Cross Lauren , Simonoff Emily , Downs Johnny 
Published: February 2020

Abstract
Background : The use of new technologies and methodologies in young people’s mental health research is needed to allow more frequent and reliable sampling. Mobile applications and e-platforms create exciting potential for the collection of large-scale cohort data, however there are various feasibility and ethical issues to consider. Consultation with young people is needed to inform the research agenda, and ensure these technologies are engaging, useful and safe. This article describes the process of Public and Patient Involvement (PPI) with a sample of young people in London, with the aim of i) informing the development of a mood-monitoring e-platform, and ii) providing feedback and advice for researchers developing web-based technologies in the mental health field. Methods : A total of 26 young people were consulted across four advisory group sessions. All young people were students enrolled at one of the participating London based sixth form colleges, and voluntarily attended a workshop session. Audio recordings of the sessions were analysed using a theory driven thematic analysis framework. Results: Young people were generally receptive to e-health technologies and valued the opportunity to collaborate throughout the development process. The advisory groups identified key considerations for future web-development work to encourage engagement and prolonged use, including, the promotion of trust and transparency, consideration of accessibility, provision of support, production of engaging and functional design, and acknowledgment of specific contextual influences surrounding young people’s wellbeing. Conclusions : Involving young people in the development process of e-health technologies contributes to optimising the successful adoption and prolonged usage of new methodologies. The thematic map outlines can be used to inform researchers interested in developing web-based technologies in the mental health field and will be directly applicable to the development of a mood-monitoring e-platform.
Understanding the impact of a new Pharmacy Sore throat Test and Treat service on patient experience: A quantitative study
Authors: Mantzourani Efi , Cannings-John Rebecca , Evans Andrew , Ahmed Haroon , Meudell Alan , Hill Ian , Williams Emma , Way Cheryl , Hood Kerenza , Legay Benjamin , Houldcroft Laura , Deslandes Rhian 
Published: February 2020

Abstract
Background : A pilot of the first NHS funded Sore Throat Test and Treat (STTT) service in the United Kingdom began in selected community pharmacies in Wales in November 2018. The aim of this research was to explore whether a pharmacist delivering consultation for sore throat that included clinical scoring and point-of-care testing was acceptable to patients, and how this might influence future health-seeking behaviour for subsequent sore-throats. Methods : Quantitative research was employed, with a non-experimental design using a survey research tool including a mix of closed and open questions, developed in collaboration with members of the public. The patient experience survey was distributed to all patients who had completed a consultation between November 2018 and May 2019. Data from completed surveys were entered in Jisc Online Surveys® and exported to Excel® for descriptive statistics. Free-text comments were analysed using content and inductive thematic analysis. Results : A total of 510 surveys were received from 2,839 sore throat consultations (response rate 18%). Overall, 501 patients (98%) were satisfied with the service. Patients’ confidence in managing their condition and service satisfaction was not dependent on having been supplied antibiotics. A total of 343 patients (67%) requested a GP appointment but were offered to a consultation in the pharmacy. After the service, 504 patients (99%) stated that they would return to the pharmacy for subsequent sore throat symptoms. Inductive analysis of free-text comments (n=242) revealed 3 themes: convenience and accessibility; professionalism of pharmacy team; and perceived value of the service. Conclusions : Results confirmed high levels of patient satisfaction with the new service, the way it was delivered and the increased choice of options for sore throat symptom management it offered. Whilst this research can only discuss patients’ reported future behaviour, the patient-reported stated intentions signify a potential shift in health-seeking behaviour towards a pharmacist-led service. This has important implications in supporting the long term plan of the governments in Wales and England to redirect management of uncomplicated conditions from GPs to pharmacies.
Supplementation of c-type natriuretic peptide during the whole in vitro growth period benefits the development of murine secondary follicles
Authors: Li Ang , Cao Haixia , Li Hongxia , Li Ruijiao , Wang Huaixiu , Guo Xingping 
Published: February 2020

Abstract
Background: Supplementation of c-type natriuretic peptide (CNP) in the culture medium shortly before in vitro maturation (IVM) has been reported to be effective in delaying meiotic resumption of murine oocyte. The present study investigated the effect of CNP supplementation during the whole period of in vitro growth (IVG) on the development of murine secondary ovarian follicles.Methods: Late secondary ovarian follicles isolated from ovaries of Kunming mice were cultured in vitro with and without supplementation of CNP. In experiment 1, CNP was supplemented at the early stage and the follicle development was evaluated. In experiment 2 and 3, CNP was supplemented during the whole period of IVG. In experiment 2, follicle development and oocyte maturity were evaluated. In group 3, follicle development and rate of cleaved embryos after in vitro fertilization (IVF) was assessed.Results: In control group in all 3 experiments, granulosa cells migrated from within follicle and adhered to the plate at different degrees. The follicles flattened and could not reach antral stage. About 39.8% (39/98) of the oocytes ovulated nakedly. As no antral follicle was obtained, IVF was not performed in control group in experiment 3. In experiment group in all 3 experiments, no migration of guanulosa cells was observed and the follicles grew three-dimensionally. Ovulation of naked oocyte decreased substantially. The rate of antral stage follicle were 45% (18/40) in experiment 1. This parameter was 75.9% (44/58) in experiment 2 and 3 combined. In experiment 2, in preovulatory follicles without ovulation induction, oocytes at germinal vesicle (GV) stage and germinal vesicle breakdown (GVBD) stage were 87.5% (14/16) and 12.5% (2/16), respectively. In preovulatory follicles with ovulation induction, no GV stage oocyte was retrieved, oocytes at GVBD and metaphase II (MII) stage were 50% (8/16), respectively. In experiment 3, among 18 follicles cultured, 12 cumulus-oocyte complexes (COC) ovulated automatically after ovulation induction. Eleven oocytes were fertilized and cleaved. Compared with control groups, the follicle development assessed by naked oocyte ovulation and follicle stage (preantral follicle and antral follicle) in experiment groups were significantly superior (p<0.0001). CNP effectively maintained oocytes’ meiotic arrest and enhanced fertilization competency.Conclusions: The supplementation of CNP in culture system of murine late secondary follicle during the whole period of IVG could sustain the 3-dimensional structure of follicle, increase the antral formation rate. As a result, the oocyte’s competency to be fertilized was greatly improved.
LIF level is a predictive marker for clinical pregnancy following IVF-ET of patients with fallopian tube obstruction
Authors: Li Zewu , Li Ruimei , Dai Huiying , Li Xiaoyun , Han Xiao , Wang xuenan , Yang Aijun 
Published: February 2020

Abstract
Background: Leukemia inhibitory factor (LIF) has played a vital role in a series of reproductive events, including follicle growth, embryo growth and differentiation. However, it is unclear whether the level of LIF in embryo culture medium can be used as a marker for clinical pregnancy. In this study, we aimed to investigate whether LIF level in embryo culture medium can act as a predictive marker for pregnancy outcome of in vitro fertilization-embryo transfer (IVF-ET) in infertile patients due to tubal problems.Methods: A total of 104 infertile patients due to tubal problems underwent IVF-ET treatment. The patients were divided into two groups according to whether they were clinically pregnant. The level of LIF in the embryo culture medium was measured, and the correlation between LIF level and embryo quality and clinical pregnancy outcome was analyzed. The embryo culture medium was collected on the day of blastocyst transplantation.Results: Compared to non-pregnant group, LIF level in the embryo culture medium on the day of blastocyst transplantation was significantly higher in the pregnant group.Conclusions: LIF level in the embryo culture medium may be used as a non-invasive auxiliary biomarker for predictive clinical pregnancy in infertile patients with tubal problems that using single blastocyst transfer method.
Arthroscopic pie-crusting release of the posteromedial complex of the knee for surgical treatment of the medial meniscus injury
Authors: Han Xu , Wang Peizhao , Yu Jinyang , Wang Xiao , Tan Honglue 
Published: February 2020

Abstract
Background: Arthroscopic narrow posteromedial gap of the knee may cause the failure of meniscus operation. The posteromedial complex (PMC) of the knee, including the posterior part of MCL and posterior oblique ligament, has a restrictive effect on the opening of the posteromedial gap of the knee in the half-extension position. Thus, we evaluated the radiological and clinical results of pie-crusting release of PMC for arthroscopic meniscal surgery in tight knees.Methods : Sixty patients with posterior injury of the medial meniscus were reviewed. All patients accepted arthroscopic pie-crusting release of the PMC. Fourty patients accepted meniscoplasty, and 20 patients accepted meniscuc suturing. To evaluate the arthroscopic opening of the medial gap in 20°half-extension under 11-kg valgus stress, the width of the medial space before and after release were measured. During follow-up, the medial stability was evaluated by radiographic measurements of the joint space width (JSW) in 20°half-extension. MRI was conducted to evaluate the healing of MCL and meniscus. Knee functions were evaluated using VAS, Lysholm, IKDC and Tegner scoring systems. Results: In all patients, meniscus operations were performed without iatrogenic cartilage injury. After PMC release, the arthroscopic width of the medial space was 5.7 ±0.5 mm, showing larger than that before release (2.5 ± 0.5 mm) (p < 0.01). The follow-up time was 21.93±7.04 months, there was no residual valgus laxity of the knee. The radiographic JSW was 5.97 ± 0.8 mm preoperatively, 9.2 ± 1.1 mm in the postoperative 1st week, and 6.1±0.9 mm in the postoperative 3rd months, showing no differences between pre- and postoperative 3rd month (p > 0.05). For sutured meniscus, MRI showed healing in 15 patients while five had two-grade abnormal signals. VAS, Lysholm, IKDC and Tegner scores were 1.80±0.51, 80.08±3.74, 82.17±4.64 and 5.48±0.59, respectively, showing significant differences compared with the preoperative scores (5.57±0.69, 48.17±4.22, 51.42±4.02 and 3.20±0.68, respectively) (P < 0.01).Conclusion s: Pie-crusting release of PMC can increase the posteromedial space and improve the visual field of the knee under arthroscopy, and this technique do neither produce residual valgus instability of the knee nor affect clinical outcome at the final follow-up.
Mid-term results of bilateral synchronous total hip arthroplasty for bony ankylosis in patients with ankylosing spondylitis
Authors: Han Lei , Liu Jing Jing , Pei Zhen le , Cao Guo ping , Hu Yun gen , Quan Ren fu 
Published: February 2020

Abstract
Background: Total hip arthroplasty (THA) for bony ankylosis is technically challenging in patients with ankylosing spondylitis (AS). This study aimed to determine the mid-term results of bilateral synchronous THA for bony ankylosis in patients with AS.Methods: Nineteen cases of bony ankylosis in patients with AS who received bilateral synchronous THA were included in this study (17 males and 2 females, mean age 49.2 years). Disease duration was 5–38 years (mean 18 years and 6 months). All patients received cementless THA. Intraoperative blood loss, visual analogue scale (VAS) score, and complications were assessed. Harris hip scores evaluated the clinical effect.Results: Patients were followed up for 62–98 months (mean 82.5 months). VAS score decreased from 7.42±0.92 to 2.42±0.83, Harris hip score improved from 21.8±7.2 to 80.3±6.5, and the flexion-extension range of the hip improved from 0°to 142.3±6.2°. One patient with septum bronchiale had a fracture intraoperatively and was treated with wire strapping. One patient had a traction injury of the femoral nerve postoperatively and recovered 1 year after the operation. Loosening and subsidence were not observed in all patients. Heterotopic bone formation was noted in 3 patients. No complications such as joint dislocation, acute infection, and deep vein thrombosis were found.Conclusion： Bilateral synchronous THA was effective for bony ankylosis of the hip in patients with AS because it improved patients’ quality of life, and had satisfactory mid-term outcomes.
The nexus between money growth and inflation in Turkey: New evidence from a Wavelet Analysis
Authors: Tursoy Turgut , Mar’i Muhammad 
Published: February 2020

Abstract
The study investigates the lead-lag relationship in Turkey by employing wavelet analysis, mainly continuous wavelet analysis, cross wavelet transforms and wavelet coherence and phase-difference, during the period from 1987 to 2019. Our finding confirms the existing relationship between money supply and inflation, and also showing a different pattern for the structure of the relationship between money supply and inflation; moreover, the result corresponds with the fact that Turkey experienced many economic crises during the period. Additionally, the results show that the lead-lag relationship between money supply and inflation is changeable and the inflation leads as a result of the Demand-pull theory. The result is consistent with the traditional quantity theory of money in the long run, and; also regarding the modern quantity theory of money, there is also short-run and long-run relationship between money supply and inflation.
A mindfulness-based intervention for breast cancer patients with cognitive impairment after chemotherapy: Study protocol of a three–group randomized controlled trial
Authors: Gucht Katleen Van der , Melis Michelle , Ahmadoun Soumaya , Gebruers Anneleen , Smeets Ann , Vandenbulcke Mathieu , Wildiers Hans , Neven Patrick , Kuppens Peter , Raes Filip , Sunaert Stefan , Deprez Sabine 
Published: February 2020

Abstract
Background: Mindfulness has been applied to improve cancer care by enhancing psychological well-being. However, little is known about its impact on cognitive impairment experienced by cancer patients after chemotherapy. Mindfulness may be relevant in tackling cognitive impairment by decreasing emotional distress and fatigue, by decreasing inflammation, and by strengthening functional brain connectivity. The aim of the present study protocol is to evaluate the efficacy and mechanisms of a mindfulness-based intervention to reduce cognitive impairment in breast cancer patients after chemotherapy. Methods: The present study is a three-arm parallel-group randomized controlled trial with assessments at baseline, one to three weeks after the intervention and at three months follow-up. One hundred twenty breast cancer patients who ended treatment minimum 6 months and maximum 5 years before and who have cognitive complaints will be enrolled. They will be randomized into one of the following 3 study arms: (1) a mindfulness-based intervention group (n=40), (2) an active control condition based on physical training (n=40), or (3) a treatment as usual (TAU) control group (n=40). Both the mindfulness-based intervention and the active control condition exist of 4 group sessions (3 hours for the mindfulness condition and 2 hours for the physical training) spread over 8 weeks. The primary outcomes will be cognitive complaints as measured by the cognitive failure questionnaire and changes in functional brain connectivity in the attention network. Secondary outcomes will be (1) levels of emotional distress, fatigue, mindfulness, quality of life; (2) neurocognitive tests; (3) structural and functional brain changes using MR imaging, and (4) inflammation. Discussion: The study will examine the impact of a mindfulness-based intervention on cognitive impairment in breast cancer patients. If the findings of this study confirm the effectiveness of a mindfulness-based program to reduce cognitive impairment, it will be possible to improve quality of life for ex-cancer patients. We will inform health care providers about the potential use of a mindfulness-based intervention as a non-pharmaceutical, low-threshold mental health intervention to improve cognitive impairment after cancer. Trial registration: ClinicalTrials.gov, NCT03736460. Retrospectively registered on 8th November 2018
Evaluation of global forcing datasets for hydropower inflow simulation in Nepal
Authors: Bhattarai Bikas Chandra , Burkhart John Faulkner , Tallaksen Lena M. , Xu Chong-Yu , Matt Felix Nikolaus 
Published: February 2020

AbstractDischarge over the Narayani river catchment of Nepal was simulated using Statkraft's Hydrologic Forecasting Toolbox (Shyft) forced with observations and three global forcing datasets: (i) ERA-Interim (ERA-I), (ii) Water and Global Change (WATCH) Forcing Data ERA-I (WFDEI), and (iii) Coordinated Regional Climate Downscaling Experiment with the contributing institute Rossy Centre, Swedish Meteorological and Hydrological Institute (CORDEX-SMHI). Not only does this provide an opportunity to evaluate discharge variability and uncertainty resulting from different forcing data but also it demonstrates the capability and potential of using these global datasets in data-sparse regions. The fidelity of discharge simulation is the greatest when using observations combined with the WFDEI forcing dataset (hybrid datasets). These results demonstrate the successful application of global forcing datasets for regional catchment-scale modeling in remote regions. The results were also promising to provide insight of the interannual variability in discharge. This study showed that while large biases in precipitation can be reduced by applying a precipitation correction factor (p_corr_factor), the best result is obtained using bias-corrected forcing data as input, i.e. the WFDEI outperformed other forcing datasets. Accordingly, the WFDEI forcing dataset holds great potential for improving our understanding of the hydrology of data-sparse Himalayan regions and providing the potential for prediction. The use of CORDEX-SMHI- and ERA-I-derived data requires further validation and bias correction, particularly over the high mountain regions.