bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural evidence for kinetic and thermal stability changes of α-amylase due to exposure to [emim][lactate] ionic liquid
Authors: Akhavan Tina , Ebrahimi Mehdi , Hekmat Azadeh 
Published: November 2020

Abstract

Objectives
α-amylases hydrolyze α-1,4 glycosidic bonds in starch. ILs used as co-solvent in different enzymatic reactions to improve activity, selectivity and stability of enzymes. In this study, fluorescence spectroscopy method was used to explain the effect of [emim][lactate] on kinetic and thermal stability of Aspergillus oryzae α-amylase.

Methods
Effect of different concentrations of [emim][lactate] on activity of α-amylases was determined. Kinetic parameters, optimum pH and temperature and thermal stability were determined and compared with absence of [emim][lactate]. Intrinsic fluorescence spectroscopy for Trp residues was performed for both presence and absence of [emim][lactate].

Results
Activity of α-amylase decreases in presence of [emim][Lac]. Moreover, Km of α-amylase in the presence of [emim][lactate] increases while Vm decreased. Optimum temperature in presence of [emim][lactate] increases from 45 to 50 °C while optimum pH decreases from 9 to 7. Thermal stability of α-amylase in the presence of [emim][lactate] is similar to that in the absence of [emim][lactate] at 40 and 50 °C but decreases at 60 °C. Intrinsic fluorescence spectroscopy shows unfolding of native structure of α-amylase is dependent on [emim][lactate] concentration.

Conclusions
Presence of [emim][lactate] ionic liquid as co-solvent leads to structural unfolding of α-amylase and loss of its activity and thermal stability.
Rapid Retooling for Emergency Response with Hybrid Manufacturing
Authors: Saleeby Kyle , Feldhausen Thomas , Love Lonnie , Kurfess Thomas 
Published: November 2020

Abstract
The global manufacturing industry has served as a keystone in supporting the weight of emergency response operations during the coronavirus disease (COVID-19) pandemic. Development of core technologies necessary to prevent the spread of COVID-19, including Personal Protective Equipment, infection testing kits, and vaccine research supplies, requires intensive manufacturing operations to support a population at scale. The production of these items is traditionally dependent on the tool and die industry, requiring imports of steel castings from overseas suppliers. The United States (U.S.) manufacturing industry was left isolated and unprepared as international borders closed overnight and normal supply chains were cut. This technical note provides a forward-looking approach at the benefits of hybrid manufacturing processes to provide rapid reconfiguration capabilities in the U.S. tool and die industry. A demonstration in rapid production of new tooling is provided to illustrate these benefits. Finally, emerging hybrid technologies are discussed in pursuit of more flexible manufacturing operations.
Cybersecurity Assurance in the Emerging Manufacturing-as-a-Service (MaaS) Paradigm: A Lesson from the Video Streaming Industry
Authors: Tiwari Akash , Narasimha Reddy A. L. , S. Bukkapatnam Satish T. 
Published: November 2020

Abstract
The coronavirus disease 2019 outbreak has incapacitated physical supply chains of various industrial sectors. This has been a call for attention to rethinking innovative methods to improve supply chain resilience. Emerging manufacturing technologies like additive/hybrid manufacturing are enabling small and medium enterprises (SMEs) to transform into cybermanufacturing kiosks that deliver manufacturing-as-a-service by digitizing much of the manufacturing workflow (design, communication, and manufacturing). This transformation is causing a paradigm shift in which major producers and original equipment manufacturers can outsource manufacturing of components to distributed SMEs located near the point of need. The increasing reliance on a digital thread would reduce the burden of resiliency required from the physical supply chains. Although digital threads are reducing the burden on the physical supply chains, they introduce a new class of cyber-resilience requirements, chiefly in ensuring the integrity of the designs and other intellectual properties shared across the digital thread. A novel design-sharing scheme for the digital thread based on video streaming is introduced herein to address the issue of IP theft and tampering. The potential of design-sharing schemes for the improvement of the cyberresilience of digital supply chains is discussed.
A Model for the Origin of Motion Direction Selectivity in Visual Cortex
Authors: Freeman Alan W. 
Published: November 2020

Motion perception is a vital part of our sensory repertoire in that it contributes to navigation, awareness of moving objects, and communication. Motion sense in carnivores and primates originates with primary visual cortical neurons selective for motion direction. More than 60 years after the discovery of these neurons, there is still no consensus on the mechanism underlying direction selectivity. This paper describes a model of the cat's visual system in which direction selectivity results from the well-documented orientation selectivity of inhibitory neurons: inhomogeneities in the orientation preference map for inhibitory neurons leads to spatially asymmetric inhibition, and thus to direction selectivity. Stimulation of the model with a drifting grating shows that direction selectivity results from the relative timing of excitatory and inhibitory inputs to a neuron. Using a stationary contrast-reversing grating reveals that the inhibitory input is spatially displaced in the preferred direction relative to the excitatory input, and that this asymmetry leads to the timing difference. More generally, the model yields physiologically realistic estimates of the direction selectivity index, and it reproduces the critical finding with contrast-reversing gratings that response phase advances with grating spatial phase. It is concluded that a model based on intracortical inhibition can account well for the known properties of direction selectivity in carnivores and primates.SIGNIFICANCE STATEMENTMotion perception is vital for navigation, communication, and the awareness of moving objects. Motion sense depends on cortical neurons that are selective for motion direction, and this paper describes a model for the physiological mechanism underlying cortical direction selectivity. The essence of the model is that intracortical inhibition of a direction-selective cell is spatially inhomogeneous and therefore depends on whether a stimulus generates inhibition before or after reaching the cell's receptive field: the response is weaker in the former than in the latter case. If the model is correct, it will contribute to the understanding of motion processing in carnivores and primates.
GERAKAN HIJRAH DAN KONSTRUKSI EMOSI KEISLAMAN DI PERKOTAAN
Authors: Fuad Sahlul 
Published: November 2020

Abstract. This paper discusses the construction of Islamic Islamic emotions in urban areas as a reflection of the influence of the hijrah movement that is widespread in Indonesia,. The growth of the Muslim middle class and the rapid advancement of information technology in Indonesia has become fertile ground for the increasing migration movement among millennial. The movement of hijrah is an expression of new Islamic emotions that brings together the spirit of religiosity and the lifestyle of the middle class. However, along with the increasing trend of transnational ideologies that lead to fundamentalism and radicalism movements, the migration movement has the potential to support transnational ideological movements targeting young people who are new to Islam. Abstrak. Paper ini membahas tentang konstruksi emosi keislaman muslim perkotaan sebagai refleksi atas pengaruh gerakan hijrah yang berkembang luas di Indonesia, khususnya di kawasan perkotaan. Pertumbuhan kelas menengah muslim dan kemajuan teknologi informasi yang pesat di Indonesia menjadi lahan yang subur bagi meningkatnya gerakan hijrah di kalangan millenial. Gerakan hijrah merupakan ekspresi emosi keislaman baru yang mempertemukan antara semangat religiusitas dan gaya hidup kelas menengah. Namun, seiring dengan meningkatnya kecenderungan ideologi transnasional yang mengarah pada gerakan fundamentalisme dan radikalisme, gerakan hijrah menjadi potensial sebagai pendukung gerakan ideologi transnasional yang menyasar para generasi muda yang baru mengenal Islam.
Adaptación chilena de la Escala de Bienestar Adolescente EPOCH
Authors: Ortiz Paulina , Leiva Gutiérrez Jose , Proestakis Alejandro 
Published: November 2020

Existe en la actualidad un creciente interés de la promoción del bienestar en los contextos educativos, lo que ha llevado a diversos autores a proponer modelos para evaluar el bienestar y la creación de instrumentos en esta línea. Uno de los instrumentos utilizado para evaluar bienestar adolescente es la escala EPOCH, basada en el modelo PERMA y que comprende las dimensiones de engagement, conectividad, felicidad, optimismo y perseverancia. La presente investigación tuvo por objetivo adaptar la Escala de Bienestar Adolescente EPOCH elaborada por Peggy Kern, Lizbeth Benson, Elizabeth A. Steinberg y Laurence Steinberg (2016). Se recolectaron datos de 1558 estudiantes entre 11 y 18 años de edad, pertenecientes a cuatro establecimientos educativos de la región de Antofagasta, Chile. Se estudió la capacidad discriminatoria de los ítems, así como también la estructura factorial del instrumento. Los resultados obtenidos muestran un comportamiento psicométrico aceptable y una estructura similar a la planteada por las autoras. Podemos concluir que la escala EPOCH es una herramienta útil para la evaluación del Bienestar de Adolescentes, en contextos educativos chilenos.
Current opportunities of comprehensive therapy for bone metastases from thyroid cancer
Authors: Polyakov A. P. , Rumyantsev P. O. , Nikiforovich P. A. , Mordovsky A. V. , Chistyakova E. A. 
Published: November 2020

Background. Approximately 10 % of patients with well-differentiated thyroid cancer (WDTC) develop distant metastases. Of them, only 23 % have bone metastases. Complications associated with metastatic lesion in the skeleton significantly affect overall condition of patients and their quality of life. Surgery and pharmacotherapy are highly traumatic and toxic. Bisphosphonates are stable structural analogues of pyrophosphate that inhibit osteoclast activity, thereby reducing bone resorption, which increases the time to development of bone complications, improves patient’s quality of life, and reduces pain.The study objective is to assess performance status and pain severity in WDTC patients with distant bone metastases after bisphosphonate therapy.Materials and methods. We analyzed clinical experience in using bisphosphonates in WDTC patients treated in P.A. Herzen Moscow Oncology Research Institute between 2016 and 2020. This study included 41 patients with WDTC and bone metastases of various locations. Pain severity was evaluated using a 5-point verbal scale; performance status was evaluated using the Eastern Cooperative Oncology Group scale.Results. We observed an improvement in patients’ performance status (from score 2 to 0 according to the Eastern Cooperative Oncology Group scale) in response to therapy. We also found a decrease in pain intensity (from score 4 to 1.5).Conclusion. The inclusion of bisphosphonates into the treatment scheme for WDTC patients with bone metastases can reduce pain intensity and improve performance status.
Treatment strategy for patients with esthesioneuroblastoma and long-term outcomes
Authors: Oganyan E. R. , Mudunov A. M. , Alieva S. B. , Pirogova N. A. , Markovich A. A. , Kurbanova L. A. 
Published: November 2020

The study objectiveis to summarize clinical experience in the treatment of esthesioneuroblastoma (ENB) accumulated by specials at N.N. Blokhin National Medical Research Center of Oncology.Materials and methods. We analyzed the data of 115 ENB patients who had undergone treatment between 1965 and 2019.Results. The 15-year overall survival rate was 1.2–1.7 times higher in patients receiving comprehensive treatment (47.7 ± 11.3 %) than in those receiving other types of therapy. In addition to that, comprehensive treatment ensured the highest rates of 3-year, 5-year, and 10-year relapse-free survival (49.3 ± 11.8 %), as well as the longest median survival (7.2 years). Chemoradiotherapy was effective in 34.8 % of patients with locally advanced ENB, while in 9 out of 45 patients (20.0 %), it resulted in partial response, which suggest that such treatment can control aggressive disease course and increase survival. Surgical treatment (alone or in combination with chemotherapy and radiotherapy) was indicated for 64 patients. However, only in 43 of them (67.1 %), it was performed as originally planned. Five patients (7.8 %) had partially radical surgeries and sixteen patients (25.1 %) had non-radical surgeries.Conclusion. The most effective treatment strategy for locally advanced ENB is a combination of surgery, chemotherapy, and radiotherapy. Chemoradiotherapy at the first stage followed by surgery was found to be an optimal treatment scheme. Tumor sensitivity to chemo- and radiotherapy affects both short-term and long-term treatment outcomes. Partially radical surgeries for locally advanced ENB are acceptable if conservative treatment is planned after operation. Treatment strategy should depend on the tumor spread (stage), grade, and proliferative activity, as well as patient’s age, somatic status, and comorbidities. Multivariate analysis has demonstrated that none of treatment methods decrease survival. The most significant factors negatively affecting the prognosis were as follows: T3–4 tumor, involvement of regional lymph nodes before treatment initiation, distant metastasis, grade IV tumor, and Ki-67 index >21 %.
Yoga for Substance Use Disorder in Women: A Systematic Review
Authors: Brooks Jennifer , Lawlor Shauna , Turetzkin Sarah , Goodnight Christy W. , Galantino Mary Lou 
Published: November 2020

Abstract
It has been suggested that yoga may be an effective adjunct intervention in the management of substance use disorders (SUD). Additionally, women with SUD require different treatment approaches than men. The objective of this study was to critically evaluate the evidence for the effectiveness of yoga, specifically for women, as part of treatment for SUD. Nine electronic databases were searched from inception to January 2020. Randomized controlled trials (RCT) that evaluated any type of yoga, including yoga as a component of mindfulness-based treatment, against any type of control in individuals with any type of addiction were eligible. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Checklist and Statement, methodological quality was appraised using Physiotherapy Evidence Database (PE Dro) criteria. Ten RC Ts (eight mixed-gender and two female-focused) met the eligibility criteria. Most of these RCTs were small to medium-sized, with various methodological and analytical flaws and deficits. The types of addictions included in these studies were alcohol, drug, and nicotine addiction. Most RCTs suggested that various types of yoga, primarily Hatha Yoga and its components, led to favorable or equivalent results for SUD as an adjunct to control or treatment-as-usual interventions. There are limited results on the impact of yoga for SUD specifically focused on women and their unique needs. Although the results of mixed-gender articles are encouraging, large RCTs with gender-specific subanalyses are required to better determine the benefits specific to women incorporating yoga for SUD.
On the Issue of the Concept of Bankruptcy
Authors: Suvorov E. D. 
Published: November 2020

The paper justifies the statement concerning the multiplicity of the concept of “bankruptcy”, and interpretes the relevant meanings. The author states that bankruptcy can be considered as: 1. an economic condition, failure to satisfy creditors’ claims, including the failure recognized by the court; 2. a procedure; 3. an objection on behalf of the debtor; 4. a basis for a special settlement regime with creditors and such a special settlement regime itself; 5. a type of enforcement proceedings; 6. a way of authorizing insolvency; 7. a model of administration; 8. a basis and order of liquidation of a legal entity. A preliminary agreement concerning the meaning of the term “bankruptcy” is necessary at all stages of the life of law: when a rule of law is created, applied and when it is being subjected to doctrinal debates aimed at identifying its meaning. Particular attention in the paper is paid to the concepts of insolvency and property insufficiency. The author argues that it is necessary to distinguish the signs of bankruptcy from insolvency, and the former from the grounds for initiating proceedings. In author’s opinion, the introduction of the category of insufficiency of property in 2009 as grounds for mandatory filing for bankruptcy by the debtor’s principal was a step backwards and does not meet the needs of the modern economy. To remedy the situation, the Supreme Court of the Russian Federation introduced the category of objective bankruptcy that is also ambiguous. The paper also focuses on bankruptcy as a special settlement regime with creditors based on the application of the principle of equality of creditors (pari passu). It is stated that this principle is the reason for the emergence, along with the executive proceedings, of a special regime, namely: bankruptcy.
Refining the 2018 Mw 7.5 Papua New Guinea Earthquake Fault-Slip Model Using Subpixel Offset
Authors: Chong Jeng-Hann , Huang Mong-Han 
Published: November 2020

ABSTRACT
The Mw 7.5 earthquake that struck central Papua New Guinea in 2018 was the largest event ever recorded in the region with modern seismic instruments. The ground motions associated with this event also triggered widespread landslides and affected more than 500,000 people. However, due to the absence of a local seismic and Global Positioning System network in the vicinity, the fault location, system, and slip distribution of this earthquake are not well documented. In this study, we use the subpixel offset method on the Copernicus Sentinel-1 Synthetic Aperture Radar (SAR) images to calculate the 3D coseismic displacement of the 2018 Papua New Guinea earthquake. The results show clear fault traces that suggest coseismic slip on the Mubi fault and the Mananda fault that triggered landslides that spread out in a more than 260  km2 region. Finite-source inversions based on the subpixel offset measurements show up to 4.1 and 6.5 m coseismic slip on the Mubi and Mananda faults, respectively. Despite higher data uncertainty (∼0.4–0.8  m) of the subpixel offset data, synthetic resolution tests show resolvable slip above 8 km in depth. The lack of shallower slip on the west side of the Mananda fault could be due to an inflated geothermal gradient near the dormant volcano, Mount Sisa, as a slip barrier. The result of the coulomb stress change suggests possible southeastward slip propagation from the Mananda fault to the Mubi fault. Our work successfully resolves 3D coseismic displacement in highly vegetated terrains and demonstrates the feasibility of using the subpixel offset on SAR images to help our understanding of regional active tectonic systems.
The Effect of observing Ergonomic Principles and Musculoskeletal Pain on the Quality of Life Dimensions of Computer Users in Hamedan City
Authors: Chaharmahali Liana , Gandomi Farzaneh 
Published: November 2020

Introduction: Musculoskeletal disorders are one of the most common injuries among computer users, which probably affect the quality of life (QOL) and efficiency.
Methods: In this descriptive-analytical study, 150 Nordic questionnaires were distributed among computer users in Hamedan province and a total of 110 questionnaires were collected. Later, 60 participants (female: n=20 and male: n=40) were evaluated based on the inclusion and exclusion criteria. Musculoskeletal disorders and workplace ergonomic principles were considered as independent variables and quality of life dimensions were investigated as the dependent variables. Rapid Office Strain Assessment (ROSA) was applied to evaluate workplace ergonomic, Nordic questionnaire was administered to evaluated musculoskeletal disorders, and SF-36 was used to assess QOL. Data were analyzed using SPSS software version 22. Independent t-test and Pearson correlation coefficient were also run to analyze the data.
Results: According to the findings, 3% of users were in the safe zone, 16% in the alert zone, and 78% in the danger zone. The findings also showed that the most common pain segments were neck pain (85%) and back pain (75%) in women, but neck pain (52%) and back pain (55%) in men. Additionally, the results showed that ergonomics of the workplace has a negative and significant relationship with the physical dimension of QOL (R=-0/26, P=0/042). Musculoskeletal disorders have a negative and significant relationship with the general health dimension (R=-0/29, P=0/022) and with the pain dimension of the QOL (R=0/29, P=0/022). Moreover, a negative and significant relationship was observed between QOL and BMI (R=-0/49, P=0/001).
Conclusion: Based on the results, workplace ergonomics has an effect on the incidence of musculoskeletal disorders and ultimately the QOL of computer users in non-office environments and computer services.
Contribuições de Maria Aparecida Baccega aos estudos de recepção
Authors: Figaro Roseli 
Published: November 2020

Este artigo tem o objetivo de registrar e discutir as contribuições de Maria Aparecida Baccega (1943-2020) aos estudos de recepção. Trata-se de estudo bibliográfico em que se busca cotejar os principais conceitos trabalhados por Baccega com base em levantamento realizado sobre sua obra em revistas acadêmicas, livros e capítulos de livros, anais de eventos científicos bem como do registro das teses e dissertações que a pesquisadora orientou ao longo de sua vida acadêmica. Não pretende ser um levantamento exaustivo e muito menos conclusivo. Propõe-se, destacar a compreensão dela sobre os conceitos de sujeito social, produção de sentido, mediações, recepção e consumo. Este estudo se justifica porque se vincula a uma tradição de estudos sobre teóricos latino-americanos e suas contribuições relevantes para a área da comunicação.
Presencia y afectación del síndrome de burnout en instructores de TH-67 de la Escuela de Helicópteros para las Fuerzas Armadas de Colombia
Authors: Arboleda Medina Alexander , Ramírez Bryan , Ariza Ariza Leidy Gabriela , Rodríguez Guerrero Nohora  Inés 
Published: November 2020

La presente investigación pretende estimar la presencia del síndrome de burnout también conocido como “síndrome de desgaste profesional” o “síndrome del quemado en el trabajo”, y su relación con la carga laboral administrativa y operativa en la población de pilotos instructores de th-67 en la Escuela de helicópteros para las Fuerzas Armadas de Colombia. Se realizó un estudio descriptivo transversal con enfoque mixto para identificar la presencia del síndrome de burnout mediante la aplicación del test de Maslach burnout inventory, el cual evalúa tres dimensiones: realización personal, agotamiento emocional y despersonalización. De igual forma, se tuvo en cuenta la asociación con las condiciones laborales de los pilotos instructores considerando tanto las operaciones de instrucción y vuelo, como las labores administrativas y militares. Los resultados del estudio mostraron que la presencia del síndrome de burnout en los pilotos instructores no es frecuente, como se verá en los resultados de las dimensiones analizadas.Así mismo, no se observó asociación entre los factores laborales (horas de preparación, tiempo en el cargo administrativo, horas en cargo adicional, carga administrativa y años de instructor en TH-67).