bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Evolution of Protest Policing in a Hybrid Regime
Authors: Wang Peng , Joosse Paul , Cho Lok Lee 
Published: May 2020

Abstract
Using interview data from protesters and frontline police, this article examines the evolution of protest policing, from ‘soft’ to ‘hard’ models, amid the recent unrest in Hong Kong. While ‘police-centric’ explanations in the protest policing literature tend to conceive of police as intentional decision makers who can choose among a variety of strategies, we employ a mixed embeddedness framework to find that a number of factors—external to police—have deprived the Hong Kong Police Force (HKPF) of its capacity to facilitate peaceful protest through ‘soft’ strategies of communication and negotiation. These include (1) a legitimacy crisis of governance in Hong Kong (a macro-level factor), (2) the erosion of police authority within the local political culture (a meso-level factor) and (3) stylistic changes in police–protester interactions, involving the increased use of masks and collective action frames of identification as victims of police (micro-level factors). Together, these factors have inaugurated reaction spirals which have led Hong Kong’s police–public interface to an unprecedented state of breakdown, where ‘soft’ policing is now all but impossible and where the HKPF is beset by a widely subscribed demand for its outright disbandment.
Lenvatinib suppresses cancer stem-like cells in HCC by inhibiting FGFR1–3 signaling, but not FGFR4 signaling
Authors: Shigesawa Taku , Maehara Osamu , Suda Goki , Natsuizaka Mitsuteru , Kimura Megumi , Shimazaki Tomoe , Yamamoto Koji , Yamada Ren , Kitagataya Takashi , Nakamura Akihisa , Suzuki Kazuharu , Ohara Masatsugu , Kawagishi Naoki , Umemura Machiko , Nakai Masato , Sho Takuya , Morikawa Kenichi , Ogawa Koji , Ohnishi Shunsuke , Sugiyama Masaya , Mizokami Masashi , Takeda Hiroshi , Sakamoto Naoya 
Published: May 2020

AbstractIn hepatocellular carcinoma (HCC), a subset of cells defined by high CD44 and CD133 expression has been reported to possess cancer stem-like cell (CSC) characteristics and to be associated with a poor prognosis. Since the approval of the multikinase inhibitor, lenvatinib, for patients with unresectable HCC, two such inhibitors (sorafenib and lenvatinib) have been employed as first-line systemic chemotherapeutics for these patients. Based on differences in the kinase-affinity profiles between these two drugs, evidence has suggested that both exert different effects on HCC, although these differences are not fully characterized. In this study, using in vitro and a preclinical in vivo xenograft mouse model, we showed that lenvatinib alone (not sorafenib or the cytotoxic agent, 5-fluorouracil) diminished CD44High/CD133High CSCs in HCC. Furthermore, western blotting and reverse transcriptase-polymerase chain reaction analysis revealed that the expression of fibroblast growth factor receptor (FGFR)-1–4 differed between CD44High/CD133High CSCs and control cells. Analysis of the effects of selective FGFR inhibitors and FGFR small interfering RNAs on CSCs in HCC revealed that lenvatinib diminished CSCs in HCC by inhibiting FGFR1–3 signaling, however, FGFR4 signaling was not impacted. Finally, we showed that FGF2 and FGF19 were involved in maintaining CD44High/CD133High CSCs in HCC, potentially, via FGFR1–3. The findings provide novel mechanistic insights into the effects of lenvatinib on CSCs in HCC and provide clues for developing effective targeted therapies against CSCs in HCC.
Irrelevant Predictions: Distractor Rhythmicity Modulates Neural Encoding in Auditory Cortex
Authors: Makov Shiri , Zion Golumbic Elana 
Published: May 2020

Abstract
Dynamic attending theory suggests that predicting the timing of upcoming sounds can assist in focusing attention toward them. However, whether similar predictive processes are also applied to background noises and assist in guiding attention “away” from potential distractors, remains an open question. Here we address this question by manipulating the temporal predictability of distractor sounds in a dichotic listening selective attention task. We tested the influence of distractors’ temporal predictability on performance and on the neural encoding of sounds, by comparing the effects of Rhythmic versus Nonrhythmic distractors. Using magnetoencephalography we found that, indeed, the neural responses to both attended and distractor sounds were affected by distractors’ rhythmicity. Baseline activity preceding the onset of Rhythmic distractor sounds was enhanced relative to nonrhythmic distractor sounds, and sensory response to them was suppressed. Moreover, detection of nonmasked targets improved when distractors were Rhythmic, an effect accompanied by stronger lateralization of the neural responses to attended sounds to contralateral auditory cortex. These combined behavioral and neural results suggest that not only are temporal predictions formed for task-irrelevant sounds, but that these predictions bear functional significance for promoting selective attention and reducing distractibility.
Revisiting the Natural History of Pulmonary Tuberculosis: A Bayesian Estimation of Natural Recovery and Mortality Rates
Authors: Ragonnet Romain , Flegg Jennifer A , Brilleman Samuel L , Tiemersma Edine W , Melsew Yayehirad A , McBryde Emma S , Trauer James M 
Published: May 2020

Abstract

Background
Tuberculosis (TB) natural history remains poorly characterized, and new investigations are impossible as it would be unethical to follow up TB patients without treatment.

Methods
We considered the reports identified in a previous systematic review of studies from the prechemotherapy era, and extracted detailed data on mortality over time. We used a Bayesian framework to estimate the rates of TB-induced mortality and self-cure. A hierarchical model was employed to allow estimates to vary by cohort. Inference was performed separately for smear-positive TB (SP-TB) and smear-negative TB (SN-TB).

Results
We included 41 cohorts of SP-TB patients and 19 cohorts of pulmonary SN-TB patients in the analysis. The median estimates of the TB-specific mortality rates were 0.389 year−1 (95% credible interval [CrI], .335–.449) and 0.025 year−1 (95% CrI, .017–.035) for SP-TB and SN-TB patients, respectively. The estimates for self-recovery rates were 0.231 year−1 (95% CrI, .177–.288) and 0.130 year−1 (95% CrI, .073–.209) for SP-TB and SN-TB patients, respectively. These rates correspond to average durations of untreated TB of 1.57 years (95% CrI, 1.37–1.81) and 5.35 years (95% CrI, 3.42–8.23) for SP-TB and SN-TB, respectively, when assuming a non-TB-related mortality rate of 0.014 year−1 (ie, a 70-year life expectancy).

Conclusions
TB-specific mortality rates are around 15 times higher for SP-TB than for SN-TB patients. This difference was underestimated dramatically in previous TB modeling studies, raising concerns about the accuracy of the associated predictions. Despite being less infectious, SN-TB may be responsible for equivalent numbers of secondary infections as SP-TB due to its much longer duration.
Where Is the Implementation Science? An Opportunity to Apply Principles During the COVID-19 Pandemic
Authors: Taylor Stephanie Parks , Kowalkowski Marc A , Beidas Rinad S 
Published: May 2020

Abstract
The coronavirus disease 2019 pandemic represents a global crisis that has received extraordinary response from healthcare workers and scientists. One critical but potentially overlooked field in a pandemic is implementation science—the study of methods to reduce the research-to-practice gap. In this Viewpoint, we discuss the important role of implementation science during this and future pandemics and highlight considerations to maximize the utility of implementation research.
Aural philology: Herder hears Homer singing
Authors: Solanki Tanvi 
Published: May 2020

AbstractIn 1769, Johann Gottfried Herder describes a private reading experience of a remarkably paradoxical nature. He tells us that he can only read ‘his’ Homer properly when he hears Homer singing Greek, while silently reading and translating by means of his German thoughts and mother tongue. Herder’s performative reading is anchored in what I call aural philology, a method innovative in its emphasis on the aural dimension in reconstructively imagining historical epochs. It is one which demarcates cultural difference through practices of listening and their remediation into reading. The problem, for Herder, is how to constitute the particularity of the German people even in affective acts of reading that, however momentarily, suspend cultural differentiation through effects of presence. I distinguish Herder’s philology from Vico and others who emphasized the oral origins of the Homeric epic, along with recent theories of philology as an affective, aurally mediated process. The article is an alternative view on the role of media in enlightenment theories of literature and culture separate from Friedrich Kittler’s Discourse Networks 1800/1900. Herder’s aural philology identifies a moment in the history of aurality and cultural difference, one that does not move fixedly towards modernity.
Investigation of anisotropic spatial correlations of intra-event residuals of multiple earthquake intensity measures using latent dimensions method
Authors: Abbasnejadfard Morteza , Bastami Morteza , Fallah Afshin 
Published: May 2020

SUMMARYConsidering spatial correlation of multiple earthquake intensity measures (IMs) is of particular importance in loss assessment of spatially distributed assets. This subject has been investigated in previous studies under the assumption of isotropy. Considering the fact that the assumption of isotropy is not valid in general, the present study employs a non-separable covariance model based on latent dimensions method to investigate anisotropic properties of spatial correlations and cross-correlations of intra-event residuals of multiple earthquake IMs. This method leads to the generation of valid covariance matrix in order to model anisotropic spatially distributed multivariate random fields. Two sets of IMs are considered in this study; the first set consists of peak ground intensity values (acceleration, velocity, and displacement), and the second set consists of spectral accelerations at three different periods. Data of 10 earthquake events in California and Japan are utilized in this study to estimate parameters of marginal and cross-covariance models. Moreover, parameters of covariance model of regional site condition, which is considered as average shear wave velocity of top 30 m of soil profile (Vs30), are obtained in order to investigate the effect of local sited conditions on spatial correlations of IMs. It is shown that maximum range and anisotropy ratio of covariance models of intra-event residuals of IMs are correlated with those of Vs30 values. Also, it is observed that the anisotropy direction of residuals of IMs is consistent with anisotropy direction of Vs30 values. Finally, predictive models are proposed to obtain marginal and cross-covariance functions for different earthquake IMs considering anisotropy.
Policy Process And Non-State Actors’ Influence On The 2014 Mexican Soda Tax
Authors: Carriedo Angela , Lock Karen , Hawkins Benjamin 
Published: May 2020

Abstract
In January 2014, Mexico introduced a soda tax of 1 Mexican Peso (MXP) per litre. The aim of this paper is to examine the political context out of which this policy emerged, the main drivers for the policy change, and the role of stakeholders in setting the policy agenda and shaping the policy design and outcomes. Thirty-one semi-structured interviews were conducted with key stakeholders, and 145 documents, including peer-reviewed papers, policy briefs, press releases, industry, government, and CSO reports, were analysed. An iterative thematic analysis was conducted based on relevant theories of the policy process using a complementary approach, including Stages Heuristic Model, Policy Triangle Framework, and Multiple Streams Model. Results showed that a major motivation was the new administration seeking funds as they entered government. The soda tax was supported by a key group of legislators, civil society actors and by academics promoting evidence on health effects. However, the policy measure was challenged by the food and beverage industries (F&BI). Non-state actors were both formally and informally involved in setting the agenda, regardless of some of them having opposing interests on the soda tax policy. Approaches used by non-state actors to influence the agenda included: calls for action, marketing strategies, coalition building, challenging evidence, and engaging in public–private partnerships (PPPs). The effectiveness of the soda tax was highly debated and resulted in public polarization, although the framing of the outcomes was instrumental in influencing fiscal policies elsewhere. This study contributes to the debate around implementing fiscal policies for health and how power is exercised and framed in the agenda-setting phase of policy development. The article examines how the F&BI sought to influence the national strategy for obesity prevention. It argues that the experience of the soda tax campaign empowered policy advocates, strengthening national and international civil society networks.
Uterine lavage: ethics of research and clinical applications
Authors: Pennings Guido 
Published: May 2020

ABSTRACT
Uterine lavage is presented as a way to perform aneuploidy screening without IVF. The feasibility of this method was tested in a research study. This study combined a number of highly contentious ethical issues: the creation of embryos for research (very early), abortion and (moderate) payments to research participants. It is concluded that the study largely fulfils the criteria of ethical research but that the researchers should have avoided a number of steps. These steps were the inclusion of infertility patients, the performance of the research in a middle-income country and the double destination of the embryos. The next question then becomes whether it would be acceptable to apply the method in a clinical setting. Two elements complicate the introduction in the clinic: low success rate of embryo collection and risk of unintended pregnancy. The application of the method in the clinic may lead to very complicated ethical and legal situations for which both patients and doctors should be prepared.
Characteristics and Long-Term Outcomes of Pregnancy-Onset Inflammatory Bowel Disease: A Case-Control Study
Authors: Yu Amy , Friedman Sonia , Ananthakrishnan Ashwin N 
Published: May 2020

Abstract

Background
Inflammatory bowel disease (IBD) frequently affects women during their reproductive years. Although the impact of pregnancy in patients with established IBD has been widely studied, the characteristics and outcomes of patients who develop a new diagnosis of IBD during pregnancy or the postpartum year (“pregnancy-onset”) is not well characterized.

Methods
We identified all patients with pregnancy-onset IBD between 2006 and 2018 at 2 major academic referral centers. Patient and disease characteristics were abstracted and compared to those of control patients with IBD not diagnosed during pregnancy or postpartum. Diagnostic and therapeutic interventions were noted, as were long-term outcomes including disease treatment course, hospitalizations, and surgery.

Results
We identified 50 patients with pregnancy-onset IBD and 100 control patients matched for year of diagnosis. The mean age of diagnosis and duration of follow-up was similar among both patients and control patients (aged 30.4 vs 28.5 years). Among patients with pregnancy-onset disease, 30% noted symptom onset in the first trimester, 22% in the second, 24% in the third, and 24% in the postpartum year. Patients with pregnancy-onset IBD were more likely to be diagnosed with ulcerative colitis compared with control patients (76% vs 56%; P = 0.02). On multivariable analysis, pregnancy onset-disease had a 4-fold increase in the risk of hospitalization (28% vs 13%; adjusted odds ratio 4.18; 95% confidence interval, 1.26-13.91). This increased risk persisted even after excluding any index hospitalizations during pregnancy.

Conclusions
Patients with pregnancy-onset IBD more commonly develop ulcerative colitis and have a higher risk of disease-related hospitalizations.
Indirect effect of oral azithromycin on the gut resistome of untreated children: a randomized controlled trial
Authors: Oldenburg Catherine E , Hinterwirth Armin , Worden Lee , Sié Ali , Dah Clarisse , Ouermi Lucienne , Coulibaly Boubacar , Zhong Lina , Chen Cindi , Ruder Kevin , Lietman Thomas M , Keenan Jeremy D , Doan Thuy 
Published: May 2020

Abstract

Background
Antibiotic use by one individual may affect selection for antimicrobial resistance in close contacts. Here we evaluated whether oral antibiotic treatment of one child within a household affected the gut resistome of an untreated cohabiting child.

Methods
Households with at least two children &lt;5 y of age were randomized in a 1:1 fashion to a 5d course of azithromycin or placebo. To evaluate indirect effects of azithromycin treatment on the gut resistome, we randomly assigned one child in the house to azithromycin and one to placebo. In placebo households, each child received placebo. We performed DNA sequencing of rectal swabs collected 5 d after the last antibiotic dose. We estimated risk ratios for the presence of genetic resistance determinants at the class level using modified Poisson models for children in azithromycin households compared with placebo households and assessed the composition of the resistome using permutational analysis of variance (PERMANOVA).

Results
Of 58 children (n = 30 azithromycin households, n = 28 placebo households) with post-treatment rectal swabs, genetic resistance determinants were common but there was no significant difference at the class (p = 0.54 for macrolides) or gene (p = 0.94 for structure by PERMANOVA, p = 0.94 for diversity) level between untreated children in azithromycin households compared with placebo households.

Conclusions
The results are encouraging that one child's antibiotic use may not influence the resistome of another child.
Trial registration: ClinicalTrials.gov NCT03187834.
Moth flame optimizer-based solution approach for unit commitment and generation scheduling problem of electric power system
Authors: Bhadoria Ashutosh , Marwaha Sanjay 
Published: May 2020

Abstract
This paper proposes a new approach based on the moth flame optimizer algorithm. Moth flame optimizer simulates the natural fervent navigation technique adopted by moths looking for a source of light. The proposed method is further improved by priority list-based ordering; the unit commitment problem (UCP) is a non-linear, non-convex, and combinatorial complex optimization problem. It contains both continuous and discrete variables. This further increases its complexity. Moth flame optimizer is very good at obtaining a commitment pattern: allocation of power on the committed units obtained by mixed-integer quadratic programming method. Heuristic search strategies are used to adopt for the repair of minimum up and downtime, and spinning reserve constraints. MFO effectiveness is tested on the standard UCP reference IEEE model buses 14 and 30, and 10 and 20 units. The efficiency of the projected algorithms is compared to classical PSO, PSOLR, HPSO, PSOSQP, hybrid MPSO, IBPSO, LCA-PSO, NPSO, PSO-GWO, and various other evolutionary algorithms. The comparison result shows that MFO can lead to all methods reported earlier in literature.
Understanding help-seeking behaviour in relation to psychosocial support services among Japanese cancer patients
Authors: Matsui Tomoko , Hirai Kei , Gondo Yasuyuki , Sato Shinichi 
Published: May 2020

Abstract

Background
There are various psychosocial support services for cancer patients in Japan; however, their utilization rate is lower than in Western countries. The aim of this study was to investigate the actual status of the utilization of such services and the related factors of their use, using the transtheoretical model.

Methods
We conducted an Internet survey of cancer outpatients. They were asked for information on their demographics, physical status and the usage of and intention to use psychosocial support services, and to answer the Hospital Anxiety and Depression Scale.

Results
Data of 712 participants were analyzed; 111 had made use of psychosocial support services (15.6%). Participants who were younger, female, had breast cancer, experience with hormone therapy and did not have a good performance status (Karnofsky Performance Scale) more often used such services when comparing users/experiencers with non-users/inexperienced. Of the inexperienced, 538 were in the Precontemplation stage (89.5%), 62 were in the Contemplation stage (10.3%) and one was in the Preparation stage (0.2%). Approximately 35% of those in the Precontemplation stage would correspond to adjustment disorders or major depression.

Conclusions
We showed the degree of cancer patients who have used the psychosocial support services and its contents and revealed the factors related to the utilization of such services in Japan. Our study supports previous reports that cancer patients with high levels of distress do not necessarily seek support, and thus future studies should also examine other modifiable factors considering the medical settings.
Genetic assays for guano-based identification of species and sex in bats of the United States and Canada
Authors: Guan Xin , Britzke Eric R , Piaggio Antoinette J , Bergman David L , Van Pelt Lolita , Lance Richard F 
Published: May 2020

AbstractBat guano is a noninvasive, data-rich genetic resource. However, the constituent bat DNA is relatively scant, degraded, and complexed with polymerase chain reaction inhibitors. It also is comingled with a rich pool of nontarget DNA from microbes, parasites, and dietary items. We designed and tested new DNA assays for bat species identification (COX1-Bat) and sex identification (XGXYC) for use with guano and other challenging samples. We reviewed previously published assays that can be used with guano samples to obtain the same species and sex data, and attempted to validate these assays for species in which they had not previously been tested. Our results demonstrate that guano-derived DNA can be used successfully to 1) identify nearly all US and Canadian bats at the species level, or to one of three Myotis species clusters, and 2) identify the sex of at least 23 US and Canadian bat species. Our newly developed assays, and validation of previously published assays, for guano-based identification of species and sex in bats, significantly enhance the power of noninvasive sampling and genetic analysis for bat studies, management, and conservation.