bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan Asupan Vitamin B12 dengan Kadar Hemoglobin pada Vegetarian di Vihara Maitreya
Authors: Serlie Serlie , Winaktu Gracia JMT , Sinsanta Sinsanta , Winata Susanty Dewi 
Published: August 2020

Minat terhadap gaya hidup vegetarian semakin meningkat karena orang-orang semakin sadar manfaat menjadi vegetarian. Namun, pola makan vegetarian dapat menyebabkan beberapa kerugian, salah satunya adalah kekurangan vitamin. Vitamin B12 hanya dapat ditemukan secara alami pada hewan, sehingga kekurangan vitamin B12 kemungkinan besar terjadi pada vegetarian. Penelitian ini bertujuan untuk mengetahui hubungan antara asupan vitamin B12 dengan kadar hemoglobin pada vegetarian. Pada penelitian cross-sectional ini, tujuh puluh empat vegetarian di Vihara Maitreya Dutamas mengikuti penelitian pada bulan Februari 2020. Pengumpulan data dilakukan dengan pengisian kuesioner Semi-Quantitative Food Frequency Questionnaire dan pemeriksaan kadar hemoglobin dengan Hb meter. Studi ini mendapatkan hasil bahwa sebagian besar responden (85,1%) tidak mengalami anemia. Responden (60,8%) memiliki asupan vitamin B12 yang cukup dan sebagian besar (39,2%) tidak mengonsumsi suplemen vitamin B12. Dapat disimpulkan bahwa tidak ada hubungan yang bermakna antara asupan vitamin B12 dengan anemia (P = 0,057) pada vegetarian di Vihara Dutamas.
KAJIAN KARAKTER FISIOLOGIS VARIETAS PADI SAWAH PADA BUDIDAYA SECARA ORGAN
Authors: AZIEZ ACHMAD FATCHUL , Agus Budiyono  , Daryanti  , Wiyono  , Setie Harieni  , Dwi Susilo Utami  
Published: August 2020

The reality in the field shows that not all lowland rice varieties which include local varieties, old superior varieties, new superior varieties and new types of varieties are suitable for organic cultivation because each group of varieties has different physiological characters. This research was carried out with the aim of determining the suitable lowland rice varieties for organic cultivation based on physiological characters. The research was carried out through pot experiments to determine the suitability of lowland rice varieties including local varieties, old varieties, new varieties, and new types of superior varieties in organic cultivation based on their physiological characteristics. with an altitude of 113 m above sea level with inceptisol soil types and tropical climate. The results showed that organic cultivation did not reduce root permeability to N uptake except for Cisedane variety. Organic cultivation lowered the KPK for the roots of the IR64, Cianjur and Mentikwangi varieties, but increased the KPK for the roots of the Pandanwangi and Cisedane varieties. The uptake rate of N, P, and K roots in organic cultivation was not different from conventional cultivation. The uptake of N roots in organic cultivation was lower than conventional cultivation. The uptake of N, P, and K by roots between varieties was not different. Organic cultivation reduced the uptake of N stems of varieties IR64, Mentikwangi and Cisedane. Among the varieties tested, there was no difference in N uptake in conventional or organic cultivation. Organic cultivation reduced the P uptake of stems of IR64 and Mentikwangi varieties, Organic cultivation decreased total N uptake of Mentikwangi varieties. In conventional and organic cultivation, the plant N uptake of all tested rice varieties was no different.
IN-BETWEEN: IMBRICAÇÕES ENTRE ARTE, CIDADE E INSTITUIÇÃO NA OBRA VAZADORES DE RUBENS MANO / In-between: the imbrications between art, city and institution in the vazadores’ work of Rubens Mano
Authors: Ferraz Tatiana Sampaio 
Published: August 2020

Estudo de vazadores em seus múltiplos aspectos -- espaciais, artísticos, institucionais e políticos. A escolha da obra de Rubens Mano pressupõe uma perspectiva contextualista renovada da arte contemporânea sobre a cidade, que tensiona a obra na direção de um híbrido capaz de transitar entre os mundos artístico e extra-artístico, atenta estética e politicamente aÌ€ problemática urbana.Palavras-chave: Rubens Mano; Vazadores; Arte contemporânea; Espaço público.AbstractRubens Mano study of the work, in its multiple aspects - spatial, artistic, institutional and political. The artist's choice presupposes a renewed contextualist perspective of contemporary art on the city, which stresses the work towards a hybrid capable of transiting between the artistic and extra-artistic worlds, aesthetically and politically attentive to the urban problematic.Keywords: Rubens Mano; vazadores; contemporary art; public space
ROUPAS COMO CORPOS: O AGENCIAMENTO POLÍTICO DO VESTUÁRIO POR CHRISTIAN BOLTANSKI / Clothes as bodies: the political agency of clothing by Christian Boltanski
Authors: Adverse Angélica 
Published: August 2020

O artigo aborda o agenciamento das roupas no trabalho do artista Christian Boltanski. Partindo da dimensão do poder dos corpos têxteis, analisaremos como as roupas investem-se das palavras emudecidas dos corpos ausentes, constituindo-se como alegoria do testemunho e do documento histórico. A ideia central é pensar como as roupas explicitam a aniquilação humana provocada pelos regimes políticos totalitários. Analisaremos como as instalações Prendre la Parole (2005) e Personnes(2010) desvelam a presença-ausência da vida-morte na experiência política do discurso têxtil. Palavras-chave: Roupas; Corpos; Agenciamento; Política; Memória.AbstractThe article addresses the agency of clothes in the work of the artist Christian Boltanski. Starting from the dimension of the power of the textile bodies, we will analyze how the clothes invest themselves with the muted words of the absent bodies, constituting themselves as an allegory of the testimony and of the historical document. The central idea is to think about how clothes make explicit human annihilation brought about by totalitarian political regimes. We will analyze how the installations Prendre la Parole (2005) and Personnes (2010) reveal the presence-absence of life-death in the political experience of textile discourse.Keywords: Clothes; Bodies; Agency; Politics; Memory.
BORDADOS, SONHOS E PESADELOS: DESLOCAMENTOS DE TRAUMAS E OBJETOS DOMÉSTICOS NA OBRA DE ROSANA PALAZYAN / Embroidery, dreams and nightmares: displacement of traumas and domestic objects in the work of Rosana Palazyan
Authors: Rebesco Vanessa Lúcia de Assis 
Published: August 2020

O objetivo deste texto é analisar a série “... uma história que você nunca mais esqueceu?”, da artista Rosana Palazyan, elaborada entre os anos 2000 e 2002. Ainda que não intencionalmente, ao trabalhar com o bordado - prática historicamente depreciada dentro do campo das artes e associada a uma arte dita “feminina” - sobre o travesseiro (objeto considerado doméstico e não artístico), a artista coloca em xeque tanto as noções cristalizadas sobre diferenças sexuais quanto as hierarquias dos gêneros e dos objetos artísticos. Palazyan cria essa série a partir de testemunhos de adolescentes internados em uma instituição no RJ, dedicada à recuperação de jovens infratores. Além de examinar quais sentidos atravessam a utilização do travesseiro e do bordado dentro de uma série que trata de um tema dolorido, discutirei a acolhida dos testemunhos por parte da artista e o lugar de escuta que ela se coloca.Palavras-chave: Rosana Palazyan; Objetos domésticos; Bordado; Testemunho; Trauma.AbstractThe purpose of this text is to analyze the series “... a story that you never forgot?” from the Rosana Palazyan, developed between the years 2000 and 2002. Although not intentionally, when working with embroidery - a practice historically depreciated in the field of the arts and associated with a so-called “feminine art – on the pillow (and object considered domestic and non-artistic), the artist challenges both the crystallized notions about sexual differences and the hierarchies of genres and artistic objects. In addition to examining which meanings cross the use of the pillow and embroidery within a series that deals with a painful theme, we will discuss the acceptance of testimonies by the artist and the place of listening that she places herself.Keywords: Rosana Palazyan; Household objects; Embroidery; testimony; Trauma.
CORPO E AUTOEXPERIMENTAÇÃO: UMA LEITURA DA ARTCHARNELDE ORLAN A PARTIR DO PENSAMENTO PÓS-FEMINISTA DE PAUL B. PRECIADO / Body and self-experimentation: a reading of ORLAN's artcharnel from Paul B. Preciado's post-feminist thinking
Authors: Rodrigues Rejane Lopes 
Published: August 2020

A partir da década de 1960 teve início na Europa e nos EUA um novo movimento artístico conhecido como arte performativa. ORLAN, artista plástica francesa, insere-se neste movimento através de obras que incluem intervenções cirúrgicas em seu próprio corpo com o objetivo de questionar o status do corpo feminino na sociedade ocidental contemporânea. Diante disso, propomos no presente artigo, uma análise do seu trabalho a partir das considerações teóricas do filósofo e escritor transgênero Paul B. Preciado.Palavras-chave: Arte performativa; ORLAN; Gênero; Feminismo; Paul. B. Preciado.AbstractFrom the 1960s, a new artistic movement known as performative art began in Europe and the USA. ORLAN, a French artist, is part of this movement through works that include surgical interventions on her own body in order to question the status of the female body in contemporary Western society. Therefore, in this article, we propose an analysis of his work based on the theoretical considerations of the transgender philosopher and writer Paul B. Preciado.Keywords: Performative art; ORLAN; Genre; Feminism; Paul B. Preciado.
Liposomal Drug Delivery of Metronidazole for the Local Treatment of Vaginitis
Authors: B. Patel Dhara , K. Patel Jayvadan 
Published: August 2020

The present investigation was aimed to formulate liposomes containing metronidazole for local therapy of vaginitis, capable to efficiently deliver entrapped drug during an extended period of time. Liposomes were prepared by simple thin film hydration technique using soya lecithin and cholesterol. Some preliminary trials and 32 factorial design were conducted to optimize the formulation. The drug to Soya lecithin to cholesterol ratio and volume of hydration media were chosen as independent variables. The percentage drug entrapment, particle size and drug release at 12 h were chosen as dependent variables. To achieve application viscosity and further improve the stability of liposomes, the prepared liposomes were incorporated in the bioadhasive carbopol 934P gel (1%), and the system were evaluated for the in vitro drug release and drug stability in phosphate-buffer pH 4.5 and simulated vaginal fluid (VFS) at 37±10C. Stability study for liposome suspension and liposomal gel were carried out. All the performed experiments confirm the applicability of liposomes as a novel drug carrier system for the local treatment of bacterial vaginosis.
Synthesis of Novel Piperonal Derivatives and Evaluation of their Anticonvulsant Activity using A Nanoparticular Formulation
Authors: Aukunuru Jithan , Eedula Keerthana , Pasham Venkanna , Katla Venumadhav , Reddy K Srinivas 
Published: August 2020

Ancient Chinese medical literature and independent studies indicate that piperine possess anticonvulsant activity and demonstrates a high degree of safety. A similarity was also demonstrated with synthetic piperine derivatives as well. In this study, chalcones and Schiffs bases of piperonal with different any methyl ketones, and aromatic primary amines were synthesized using conventional and microwave-irradiation methods. Purification of these compounds was effected by recrystallization from alcohol and characterized by NMR and IR spectra. The synthesized compounds were screened for their anticonvulsant activity using a 4-aminopyridine induced model with the help of a conventional and a current nanoparticular formulation approach. A drug delivery system methodology in the form of nanoparticles for screening was adopted because it has more advantages when compared to conventional formulations in drug discovery stages. Nanoparticle formulations encapsulating selected synthesized compounds were prepared using solvent evaporation technique by taking polycaprolactone as the polymer. Few piperonal synthesized derivatives demonstrated anticonvulsant activity which was lesser than the standard phenytoin. Unfortunately, nanoparticular formulations prepared in this current study encapsulating selected synthesized compounds did not show any activity, suggesting more work is needed to demonstrate positive results.
Formulation and In vitro Evaluation of Floating Microspheres of Misoprostol
Authors: Vanitha K , Varma M. Mohan , Alluri Ramesh 
Published: August 2020

Misoprostol is a synthetic prostaglandin PGE1 analogue, which has proved to be an effective anti-secretory agent for oral use. The major indications of Misoprostol are in the prevention and treatment of NSAID-induced gastric and duodenal ulcers. Its half-life is 20-40 minutes. More than one third of patients with ulcers are resistant to H2 antagonists. So, these patients can be healed on Misoprostol. The objective of the present study was to formulate gastroretentive floating drug delivery system of an antiulcer drug Misoprostol. Floating microspheres of Misoprostol were prepared by an emulsification solvent evaporation technique using hydroxy propyl methyl-cellulose (HPMC K 100M) and ethyl cellulose. The percentage yield and drug entrapment efficiencies of these floating microspheres were within the range between: 70 ± 2.8 to 98 ± 2.9 % and 39.27 to 82.39 %, respectively. The determined mean particle size for all the microspheres were 250 ± 7.28 to 400 ± 2.32 µm. The flowability of these microspheres was found good. A high performance liquid chromatography (HPLC) method with ultra-violet (UV) detection was selected for the method of analysis. The drug release was found to delay for 12 hours with the increasing drug to polymer ratio. The drug release kinetics followed Korsemeyer-Peppas and Higuchi model with anomalous (non-Fickian) diffusion mechanism for the drug release. The FTIR and DSC studies showed that there was an absence of chemical interaction between the drug and the excipients. The in vitro drug release from Misoprostol floating microspheres showed the drug release was dependent on the drug to polymer ratio. The drug release was found delayed with the increasing drug to polymer ratio.
In vitro and In vivo Evaluation of Propranolol Microspheres Loaded Buccal Gel
Authors: Deshmukh Gajanan J , Varma M. Mohan , D. V. R. N. Bhikshapathi 
Published: August 2020

The selected propranolol microsphere formulation, S6 was employed for gel formulation with a variety of polymers like Carbopol 934, HPMC and Sodium CMC by mechanical stirring method in order to develop a sustained release propranolol microspheres containing bioadhesive gel. The prepared bioadhesive gels were evaluated for pH, viscosity, %drug content, in vitro drug release studies, bioadhesion, ex vivo permeation studies, accelerated stability and in vivo bioavailability studies. From all the above studies FG3 was found to be optimized formulation. In vitro experiments indicated a sustained release of 98.92% over 12 h and an acceptable bioadhesion quality for formulation FG3. Optimized formulation was characterized for FTIR, SEM and stability studies and found to be stable. Propranolol Optimized formulation exhibited significant increased bioavailability in vivo when compared with marketed tablet. The drug release from the optimized formulation follows zero order kinetics with anomalous Non-fickian diffusion. In vivo studies revealed that Propranolol Optimized formulation FG3 exhibited significant increased bioavailability when compared with marketed product, due to reduced first pass metabolism, when it is administered by the buccal route. Hence, it can be concluded that the formulation FG3 has potential to deliver Propranolol in a controlled and constant manner for prolong period over other formulations and can be adopted for a successful delivery of propranolol for buccal use.
Clinical Pharmacology of Modern Antiepileptic Drugs
Authors: Reddy D Samba 
Published: August 2020

This article describes current antiepileptic drugs (AEDs) that are available for treatment of epilepsy. Epilepsy is characterized by repeated occurrence of seizures. Epileptic seizures are classified into focal and generalized types. Around two-dozen AEDs are available for treating epilepsy. AEDs act on diverse molecular targets to selectively modify the abnormal excitability of neurons by reducing the focal seizure discharges or preventing spread of excitation. AEDs suppress seizures by blocking the voltage-gated sodium channels (phenytoin, carbama-zepine, valproate, lamotrigine, oxcarbazepine, topiramate), voltage-activated calcium channels (ethosuximide, gabapentin), potentiation of GABA inhibition (barbiturates, benzodiazepines, tiagabine), and reduction of glutamate excitation (felbamate, parampanel). Carbamazepine, phenytoin, and valproate are the first-line agents for partial seizures and generalized tonic-clonic seizures. Ethosuximide is the drug of choice for absence seizures. AEDs are orally-active and show unique pharmacokinetic features. Some AEDs cause enzyme induction and hence produce drug-drug interactions. Newer AEDs such as gabapentin, levetiracetam, tiagabine, and pregabalin do not cause enzyme induction. Despite many advances in epilepsy research, nearly 30% of people with epilepsy have drug-resistant or intractable seizures. Presently, there is no cure for epilepsy. Thus, newer and better AEDs that can better prevent refractory seizures and modify the disease are needed for curing epilepsy.
Clinical Overview of Innovative New Drug Approvals in 2017
Authors: Reddy D Samba 
Published: August 2020

The FDA has approved 46 new drugs in 2017, another record approval in two decades on a similar pace to the gangbuster year of 2015. Many of these new medicines address significant and meaningful needs, or offer additional therapeutic choices for patients worldwide. These new drugs also cover a broad range of indications including immuno-oncology (Imfinzi and Bavencio), Parkinson’s disease (Xadago), eczema (Dupixent), psoriasis (Siliq and Tremfya), multiple sclerosis (Ocrevus), and different types of cancer (Idhifa, Aliqopa, Calquence, and Besponsa). A few important orphan drugs were approved, including in mucopoly-saccharidosis type VII (Mepsevil) and Batten’s Disease (Brineuria). Many of these new drugs are for rare diseases and sub-types of cancer, which often target very small populations, although they can cost hundreds of thousands of dollars. Yet the pharma companies saw average returns on their research and development spending fall, reflecting more competitive pressures and the growing share of new products now coming from biotech companies. Recently, the US has introduced the Right-to-Try Act, wherein patients can access experimental treatments if they are unable to participate in any clinical trial of new drugs and if they have no other options. Such policies are expected to increase the database for new experimental drugs and help accelerate drug approvals.
Development and Validation of Midostaurin Assay by RP-HPLC Method
Authors: Ahmed Abrar , Mahtab Tayyaba , Saleem Sumaiyya 
Published: August 2020

Midostaurin is a multi-targeted protein kinase inhibitor that has been used for the treatment of acute myeloid leukemia. Here, a rapid and precise reverse phase high-performance liquid chromatographic method has been developed for the validation of midostaurin, in its API form as well as in capsule dosage form. Chromatography was carried out on a X-Bridge C18 (4.6 x 250 mm, 5 µm) column using a mixture of methanol: water (75:25% v/v) as the mobile phase at a flow rate of 1.0 mL/min, the detection was carried out at 243nm and the retention time of the midostaurin was found to be 3.155. The method produce linear responses in the concentration range of 10-50 µg/mL of midostaurin. The method precision for the determination of assay was below 2.0 % RSD. The LOD and LOQ values obtained were 1.2 µg/mL and 3.8 µg/mL respectively. There were no significant changes observed upon changing chromatographic conditions indicating the method to be robust. Therefore this validated method can be useful in the quality control of bulk and pharmaceutical formulations of midostaurin.
A Comprehensive Review on Solid Lipid Nanoparticles as Delivery Vehicle for Enhanced Pharmacokinetic and Pharmacodynamic Activity of Poorly Soluble Drugs
Authors: Dudhipala Narendar 
Published: August 2020

This article describes the current state and future perspectives of solid lipid nanoparticles for achieving high delivery of drugs with greater therapeutic outcomes. The oral route is the most preferred route of administration for majority of drugs. Problems such as poor solubility or chemical stability in the environment of the gastrointestinal tract, poor permeability through the biological membranes or sensitivity to metabolism are well known to result in the rejection of potential drug candidates as oral delivery products. Hence, lipid-based drug delivery systems have been proposed as a means of bypassing the resistant chemical or physical barriers associated with poorly absorbed drugs. Solid lipid nanoparticles (SLNs) can be an attractive one option for oral drug delivery vehicles as they hold tremendous potential to improve the oral bioavailability of drugs, concomitant reduction of drug toxicity and stability of drug in both GIT and plasma. SLNs are in submicron size range and are made of biocompatible and biodegradable materials capable of incorporating both lipophilic and hydrophilic drugs. SLNs are considered as substitute to other colloidal drug systems and are being used as controlled and targeted delivery systems. The SNL technology has greatly revolutionized the delivery systems for poorly soluble drugs. This article describes the methodologies used for preparation and characterization of SNLs. It outlined the development of stable solid lipid nanoparticles by different techniques. Further, it describes the current status of pharmacokinetic and pharmaco-dynamic studies reported on SLN systems. Finally, it provides a brief outlook on current marketed preparation and the future scope of SLN technology.