bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cutaneous Manifestations of COVID-19: A Systematic Review
Authors: Daneshgaran Giulia , Dubin Danielle P. , Gould Daniel J. 
Published: June 2020

Abstract
Background: The COVID-19 pandemic has affected 4.5 million people and killed over 300,000 patients. Although this virus primarily causes respiratory symptoms, an increasing number of cutaneous manifestations associated with this disease have been reported.Objective: The aim of this review was to collate and categorize the dermatologic findings reported in COVID-19 patients and identify specific lesions that may facilitate diagnosis and prognostication.Methods: A systematic review of the PubMed database was conducted on May 14th, 2020 using the search terms “Covid-19 skin,” “Covid-19 rash,” “Covid-19 exanthem,” and “Covid-19 chilblains.” Peer-reviewed publications containing original COVID-19 patient cases and a discussion of the associated cutaneous findings were included in the analysis.Results: The literature search identified 115 records, of which 34 publications describing 996 dermatologic patients were included. Case reports (n=15), case series (n=10) and observational studies (n=7) were the most common publication types. Pseudo-chilblains (PC) was the most frequent lesion identified (40.4% of cases), appearing in young adults (mean age, MA, 23.2 years) after the onset of extracutaneous COVID-19 symptoms (55/100 patients). Erythematous maculopapular rashes (EMR) affected 21.3% of patients, most frequently impacting middle-aged adults (MA 53.2 years) and occurring at the same time as non-cutaneous symptoms (110/187 patients). Vesicular rashes (VR) affected 13.0% of patients, appearing in middle-aged adults (MA 48.3 years) after the onset of other symptoms (52/84 patients). Urticarial rashes (UR) affected 10.9% of patients, appearing in adults (MA 38.3 years) and occurring at the same time as non-cutaneous symptoms (46/78 patients). Vascular rashes resembling livedo/purpura/necrosis (LPN) were uncommon (4% of cases), appearing in elderly patients (MA 77.5 years) and occurring at the same time as non-cutaneous COVID-19 symptoms (18/29 patients). Erythema multiforme-like eruptions (EME), although infrequent (3.7% of cases), affected mostly children (MA 12.2 years).Conclusions: VR may suggest an initial diagnosis of COVID-19, PC may be most appropriate for epidemiological uses, and LPN may be a useful prognostic marker for severe disease. As a potential correlate to disease severity, prognosis, or infectibility, it is critical that all health care professionals be well-versed in these increasingly common cutaneous manifestations of COVID-19.
Therapy of Early Endometrial Cancer Fertility preserving Management of Early Endometrial Cancer in a Patient Cohort at the Department of Women's Health at the University of Tuebingen
Authors: Andress Jürgen , Pasternak Jana , Weiss Martin , Walter Christina , Kommoss Stefan , Krämer Bernhard , Hartkopf Andreas , Brucker Sara Yvonne , Schönfisch Birgitt , Steinmacher Sahra 
Published: June 2020

Abstract
Background:Endometrial cancer ranges among the most common gynecologic cancers worldwide. As the incidence of causing risk factors increases it is also becoming more prevalent in younger, premenopausal women who havent´ completed family planning yet. Our study aimed to investigate the oncologic and reproductive outcome of a conservative treatment with progestin agents in early stage grade 1 endometrial cancer (G1EC), grade 2 endometrial cancer (G2EC) or complex atypical hyperplasia (CAH) in young premenopausal women. Methods:Women treated for early stage endometrial cancer or atypical hyperplasia of the endometrium with a conservative therapy between 2006 and 2018 were enrolled in this retrospective analysis. Progestin agents were orally administered on a daily basis for 3 months for at least one cycle. Endometrial tissue was obtained by hysteroscopy and Dilatation & Curettage (D&C) being performed before and after end of treatment. Therapeutic response was assessed by pathological examination.Results:A total of 14 patients were included. After treatment with progestin agents, 11 of these patients initially showed a complete or partial response. Three patients with early stage endometrial cancer did not respond. Of the three patients with initially diagnosed atypical hyperplasia, none showed any remaining disease later. Of the 8 patients with initially diagnosed endometrial cancer, who had responded to first treatment, 3 patients were re-diagnosed with endometrial cancer later. One patient with initial endometrial cancer became pregnant but aborted in the 10th week. Conclusion:Due to its good efficacy progestin agents offer a feasible therapeutic option in the fertility preserving treatment of early stage endometrial cancer in young premenopausal women. However, recurrence rate remains high in early stage endometrial cancer. Therefore, a close follow-up is mandatory, also in responders. Patients should be informed of limitations and risks of conservative treatment. Yet after completion of family planning, hysterectomy should be performed.
The effectiveness of interactive mobile health technologies in improving antenatal care service utilization in Dodoma region, Tanzania: A quasi experimental study
Authors: MASOI THERESIA JOHN , Kibusi Stephen M. , Ernest Alex , Lilungulu Athanase G. 
Published: June 2020

Abstract
Background

Antenatal care provides a platform for important health care functions during pregnancy, including health promotion, screening, and diagnosis and disease prevention. Timely and appropriate utilization of antenatal care can prevent complications and ensure better maternal and newborn health care. The aim of this study was to assess the effectiveness of interactive mobile health technologies in improving antenatal care service utilization in Dodoma region, Tanzania

Methods

A controlled quasi-experimental study was carried. Random selection of participants was employed to achieve a sample size of 450 pregnant women (Intervention=150 and Control=300). Interventions were matched to controls by gravidity and gestational age at a ratio of 1:2.The intervention group was enrolled in an interactive mobile messaging system and received health education messages. The control group continued with the standard antenatal care services being offered in local clinics. Pregnant women were followed from their initial visit to the point of delivery. Independent two-sample T-tests and logistic regression were used to test the effect of the intervention.

Results

The mean age of the participants was found to be 25.6 years with a range of 16 to 48 years. 77.3% of participants in the intervention group utilize ANC services as compared to 57.7% in the control group. The mean score was (M=2.77, SD 0.420) in the intervention group against (M=2.58, SD=0.495) in the control with (t=4.172, P<0.01) at 95% CI . Interactive SMS alert system,was observed to be effective on improving Antenatal care service utilization (AOR=2.164, P<0.05, 95% CI=1.351-3.466) as compared to conventional Antenatal care health education given in our health facilities.

Conclusion

The Interactive mobile health technologies used in this study has the potential of empowering pregnant women through greater access to information and in improving antenatal care service utilization in our setting.
Nucleation Heat Treatment on the Crystalline Fraction and Crystal Morphology of Lamav Cad Lithium Disilicate
Authors: Vallerini Bruna de Freitas , Villas-Bôas Mariana de Oliveira Carlos , Pinelli Lígia Antunes Pereira 
Published: June 2020

Abstract
Thus, this study aimed to evaluate the influence of different nucleation heat treatments on the crystalline fraction and crystal morphology of the LS2 LaMaV CAD. Discs (12 mm diameter x 1.2 mm thickness) of LS2 LaMaV CAD and IPS e.max CAD (C, control group, n=3) were made. LS2 LaMaV CAD discs were annealed at 380oC/2h followed by different nucleation heat treatments in which time and temperature were varied composing 4 groups (n=3): T1 (1h30/500oC), T2 (3h/500oC), T3 (6h/500oC) and T4 (6h/480oC). Scanning Electron Microscopy images were obtained to characterize the microstructure and to quantify the crystalline fraction using the ImageJ software. X-ray diffraction with Rietveld refinement was performed. ANOVA one-way with Tukey post-hoc test (a = 0.05) was used to analyze the ImageJ images and the Rietveld refinements for X-ray diffraction data. X-ray diffraction analysis showed peaks of approximately 86% of lithium disilicate for all groups. The morphology of crystals was in lath-shaped and homogeneous format for all groups; the group that most resembled the C group was T1. The crystalline fraction (%) was: C = 59.33 ± 0.47, T1 = 61.63 ± 0.61, T2 = 61.07 ± 1.09, T3 = 56.39 ± 0.32, and T4 = 57.48 ± 0.90, all the groups were statistically different to the C group. It was concluded that the nucleation temperature influenced the size and quantity of the crystals of lithium disilicate; treatment that showed the best result was that that received nucleation treatment for 1 hour and 30 minutes at 500ºC.
Hiv-1 Gag Gene Mutations, Treatment Response and Drug Resistance to Protease Inhibitors: A Systematic Review and Meta-analysis Protocol
Authors: NKA ALEX DURAND , Teto Georges , Santoro Maria-Mercedes , Ndze Valantine Ngum , Takou Désiré , Dambaya Beatrice , Semengue Ezechiel Ngoufack Jagni , Fabeni Lavinia , Perno Carlo-Federico , Colizzi Vittorio , Ceccherini-Silberstein Francesca , Fokam Joseph 
Published: June 2020

Abstract
Background: Some mutations in the HIV-1 Gag gene are known to confer resistance to ritonavir-boosted protease inhibitors (PI/r), but their clinical implications remain controversial and most genotyping algorithms only consider the protease gene to evaluate resistance to PI/r. Thus, a thorough analysis of existing findings would provide a better understanding on the role of HIV-1 Gag gene on the resistance to PI/r, by characterizing genotypic co-variations between Gag-mutations/polymorphisms and mutations of the protease region.Methods: We will include randomized and non-randomized trials, cohort and cross-sectional studies published in English and French (from 2012 onwards), and relevant conference reports on PI/r HIV-1 Gag gene resistance associated mutations. Hand searching of the reference lists of relevant reviews will be conducted and we will also look for the aforementioned conference abstracts. PUBMED, EMBASE, CENTRAL, CINAHL databases will be used to conduct the searches. We will include studies of adults and/or children exposed to PI/r based therapies; and we will exclude studies of patients with specific co-morbidities such as tuberculosis or opportunistic infections. Primary outcomes will be “the rate of viral suppression”, “the proportion of patients with immune recovery” and “the level of drug resistance” on protease PI/r-based regimens. Secondary outcomes will be “HIV-1 Gag gene non polymorphic mutations according to PI/r based-regimens” and “viral subtypes/recombinants”. Two reviewers will independently screen titles and abstracts, assess the full texts for eligibility and extract data. If data permits, random effects models will be used where appropriate. Subgroup and additional analyses will be conducted to explore the potential sources of heterogeneity.Discussion: This study will help to better understand the implications of the Gag gene mutations ofPI/r-based ART response for HIV positive individuals, for a potential consideration in algorithms interpreting HIV drug resistance for clinical management.Prospero registration number: CRD42019114851
Development a Nomogram to Predict Prognosis in Severe and Critically Ill Patients with COVID-19
Authors: Tan Weiping , Zhu Ying , Yi Hui , Lin Yingyu , Liu Yumei , Wu Zhentian , Si Xiang , Tang Mimi , Hu Chunlin , Liu Yongjun , Yang Yi , Chen Zhenguang , Liu Dayue , Liu Yangli , Guo Yubiao , Jiang Ke , Wan Li , Kuang Yukun , Luo Yifeng 
Published: June 2020

Abstract
Background: The number of deaths caused by COVID-19 are on the rising worldwide. This study focused on severe and critically ill COVID-19, aim to explore independent risk factors associated with disease severity and to build a nomogram to predict patients’ prognosis.Methods: Patients with laboratory-confirmed COVID-19 admitted to the Union Hospital, Tongji Medical College and Hankou Hospital of Wuhan, China, from February 8th to April 6th, 2020. LASSO Regression and Multivariate Analysis were applied to screen independent factors. COX Nomogram was built to predict the 7-day, 14-day and 1-month survival probability.Results: A total of 115 severe [73 (63.5%)] and critically ill [42 (36.5%)] patients were included in this study, containing 93 (80.9%) survivors and 22 (19.1%) non-survivors. For disease severity, D-dimer [OR 6.33 (95%CI, 1.27-45.57], eosinophil percentage [OR 8.02 (95%CI, 1.82-45.04)], total bilirubin [OR 12.38 (95%CI, 1.24-223.65)] and lung involvement score [OR 1.22 (95%CI, 1.08-1.40)] were the independent factors associated with critical illness. Troponin [HR 9.02 (95%CI, 3.02, 26.97)] and total bilirubin [HR 3.16 (95%CI, 1.13, 8.85)] were the independent predictors for patients’ prognosis. Troponin≥26.2 ng/L and total bilirubin＞20 μmol/L were associated with poor prognosis. The nomogram based on the independent risk factors had a C-index of 0.92 (95%CI, 0.87, 0.98) for predicting survival probability. The survival nomogram validated in the critically ill patients had a C-index of 0.83 (95%CI: 0.75, 0.94).Conclusions: In conclusion, in severe and critically ill patients with COVID-19, D-dimer, eosinophil percentage, total bilirubin and lung involvement score were the independent risk factors associated with disease severity. The proposed survival nomogram accurately predicted prognosis. The survival analysis may suggest that early incidence of multiple organ dysfunction may be an important predictor of poor prognosis.
Clinical and Radiological Features of Patients with Coronavirus Disease 2019
Authors: Chen Hui Juan , Qiu Jie , Wu Biao , Wang Zhen Ping , Chen Yang , Chen Feng 
Published: June 2020

Abstract
Background: Confirmed cases of coronavirus disease 2019 (COVID-19) is still increasing, detailed analysis of confirmed cases may be beneficial for disease control.Methods: To describe the clinical and radiological findings of patients confirmed with COVID-19 infection in Haikou, China.Results: A total of 67 patients confirmed with COVID-19 infection were included in this study. 50 were imported cases. Most infected patients presented with fever and cough. The typical CT findings of lung lesions were bilateral, multifocal lung lesions (52[78%]), with subpleural distribution, and more than two lobes involved (51[78%]). 54 (81%) patients of COVID-19 pneumonia had ground glass opacities. Consolidation was in 30 (45%) patients, crazy paving pattern or interlobular thickening in 17 (25%), adjacent pleura thickening in 23 (34%) patients. Additionally, baseline chest CT did not reveal positive CT findings in 7 patients (23%), but 3 patients presented unilateral ground glass opacities at follow-up. Importantly, the follow-up CT findings were fitted well with the clinical outcomes.Conclusions: Chest CT could be used as an important tool for early diagnosis of COVID-19, monitoring the disease evolution, judging the treatment effectiveness and predicting the clinical outcomes.
Identification and analysis of oil candidate genes revealed the molecular basis of oil accumulation in Gossypium hirsutum&nbsp;L. for cottonseed biofuels development
Authors: zhang zhibin , Gong Juwu , Zhang Zhen , Gong Wankui , Li Junwen , Shi Yuzhen , Liu Aiying , Ge Qun , Pan Jingtao , Fan Senmiao , Deng Xiaoying , Li Shaoqi , Chen Quanjia , Yuan Youlu , Shang Haihong 
Published: June 2020

Abstract
Background

Cottonseed oil is increasingly becoming a promising target for biodiesel production with its high content of unsaturated fatty acids as greenhouse gases emission and global warming become more severe. However, the molecular regulatory basis of cottonseed oil accumulation is still unclear so far, and it is necessary to identify vital genes and regulators involved in oil accumulation during developing cottonseed ovules.
Results

In this study, a recombinant inbred line (RIL) population, developed from a cross between upland cotton cultivars 0-153 and sGK9708, was used to detect quantitative trait loci (QTLs) associated with cottonseed oil content and further identify candidate factors regulating cottonseed lipid synthesis. A total of 39 QTLs located on eighteen different chromosomes were identified across eight different environments. Of these, five QTLs were stable in at least three environments. By integrating candidate gene approach and physical mapping data, we preliminary obtained 43 candidate genes potentially involved in carbon metabolism, fatty acid (FA) synthesis and transcription, and triacylglycerol (TAG) synthesis around the stable QTLs. KEGG pathway enrichment analysis and local BLAST with Arabidopsis oil-related genes, as well as transcriptome analysis further showed that 19 candidate genes, expressed during developing cottonseed ovules, could influence cottonseed oil accumulation. Transcription factors (TFs) and microRNAs (miRNAs) regulatory network analyses suggested six genes, two core miRNAs (ghr-miR2949b and ghr-miR2949c), and one TFs GhHSL1 were considered to be closely associated with cottonseed lipid content.
Conclusions

The study provides an unprecedented level of insight from QTL mapping and regulatory network analysis to reveal the oil accumulation mechanism in developing cottonseed ovules through the construction of a detailed oil accumulation model. Moreover, the present study of cottonseed oil also lays a foundation for further oil production improvement in oil crops, and contributes to renewable energy production for solving the energy shortage and stabilizing greenhouse gases at a certain extent.
Cloud Network Slicing: A systematic mapping study from scientific publications
Authors: Almeida Leandro , Maciel Paulo Ditarso , Verdi Fabio Luciano 
Published: June 2020

Abstract
Cloud Network Slicing is a new research area that brings together cloud computing and network slicing in an end-to-end environment. In this context, understanding the existing scientific contributions and gaps is crucial to driving new research in this field. This article presents a complete quantitative analysis of scientific publications on the Cloud Network Slicing, based on a systematic mapping study. The results indicate the situation of the last ten years in the research area, presenting data such as industry involvement, most cited articles, most active researchers, publications over the years, main places of publication, as well as well-developed areas and gaps. Future guidelines for scientific research are also discussed.
Detection of Cryptosporidium and Giardia in foods of plant origin in North-Western Greece
Authors: Sakkas Hercules , Economou Vangelis , Bozidis Petros , Gousia Panagiota , Papadopoulou Chrissanthy , Karanis Panagiotis 
Published: June 2020

Abstract
Giardia and Cryptosporidium are recognized as leading causes of waterborne and foodborne diarrhoeal disease with worldwide distribution. The study aimed to determine the protozoan contamination of various foods of plant origin. A total of 72 samples from 27 different varieties of fresh vegetables and fruits were collected from supermarkets and open markets in North-Western Greece and were examined using conventional diagnostic methods. Two out of 72 (2.8%) samples were found positive for Cryptosporidium oocysts, while no sample was found to be positive for Giardia cysts. The results show the presence of protozoan contamination in foods of plant origin, which may constitute a potential health hazard.
Effect of Antioxidants on Heavy Metals Induced Conformational Alteration of Cytochrome C and Myoglobin
Authors: Alazoumi Khadega Khamis Moh , Ahmed Anwar , Alamery Salman Freeh , Shamsi Anas , Ahmad Basir , Islam Asimul , Farooqi Humaira 
Published: June 2020

Background:The exposure to heavy metals due to unrestrained industrialization, pollution and non-degradability imposes a significant risk to human health. Proteins are prime targets of heavy metal stress, however, the underlying mechanisms and its impact on heme proteins is still not entirely clear.Objective:To analyze the deleterious effect of heavy metals such as cadmium, chromium and mercury on conformation of two proteins namely, cytochrome c and myoglobin. The protective effect of glycine and ascorbic acid (animal origin), gallic acid and sesamol (plant origin) on heavy metal exposure was studied.Methods:Far- and near-UV Circular Dichroism (CD) measurements monitored the changes in secondary and tertiary structure. Absorption Soret spectroscopy study revealed changes in heme-protein interaction. Peroxidase activity has been assayed to measure the absorption of tetraguaiacol. The interaction of heme proteins with different heavy metals was done using docking study.Results:Far- and near-UV CD measurements reveal that heavy metals disrupt the secondary and tertiary structure of heme proteins. Antioxidants counteract the deleterious effect of heavy metals. Absorption spectroscopy revealed changes in the Soret region of these heme proteins. Changes in peroxidase activity was observed on addition of heavy metals and antioxidants. Molecular docking validated interaction of the heavy metals with proteins with a significant binding affinity (-2.3 kcal/- mol).Conclusion:Heavy metals interfered and disrupted both the heme proteins and mercury showed the maximum deleterious effect, further, chromium showed detrimental effect at very small concentration. The antioxidants from animal origin exhibited better protective response than those from plant source.
Dual-target Inhibitors Based on BRD4: Novel Therapeutic Approaches for Cancer
Authors: Zhang Sitao , Chen Yanzhao , Tian Chengsen , He Yujing , Tian Zeru , Wan Yichao , Liu Tingting 
Published: June 2020

Background:
Currently, cancer continues being a dramatically increasing and serious
threat to public health. Although many anti-tumor agents have been developed in recent years, the
survival rate of patients is not satisfactory. The poor prognosis of cancer patients is closely related
to the occurrence of drug resistance. Therefore, it is urgent to develop new strategies for cancer
treatment. Multi-target therapies aim to have additive or synergistic effects and reduce the potential
for the development of resistance by integrating different pharmacophores into a single drug molecule.
Given the fact that majority of diseases are multifactorial in nature, multi-target therapies are
being exploited with increasing intensity, which has brought improved outcomes in disease models
and obtained several compounds that have entered clinical trials. Thus, it is potential to utilize this
strategy for the treatment of BRD4 related cancers. This review focuses on the recent research advances
of dual-target inhibitors based on BRD4 in the aspect of anti-tumor.

Methods:
We have searched the recent literatures about BRD4 inhibitors from the online resources
and databases, such as pubmed, elsevier and google scholar.

Results:
In the recent years, many efforts have been taken to develop dual-target inhibitors based
on BRD4 as anti-cancer agents, such as HDAC/BRD4 dual inhibitors, PLK1/BRD4 dual inhibitors
and PI3K/BRD4 dual inhibitors and so on. Most compounds display good anti-tumor activities.

Conclusion:
Developing new anti-cancer agents with new scaffolds and high efficiency is a big
challenge for researchers. Dual-target inhibitors based on BRD4 are a class of important bioactive
compounds. Making structural modifications on the active dual-target inhibitors according to
the corresponding structure-activity relationships is of benefit to obtain more potent anti-cancer
leads or clinical drugs. This review will be useful for further development of new dual-target inhibitors
based on BRD4 as anti-cancer agents.