bluuebunny/crossref_metadata_2025_split huggingface dataset:
A revision of the Dwarf Geckos, genus Lygodactylus (Squamata: Gekkonidae), from Angola, with the description of three new species
Authors: MARQUES MARIANA P. , CERÍACO LUIS M. P. , BUEHLER MATTHEW D. , BANDEIRA SUZANA A. , JANOTA JOYCE M. , BAUER AARON M. 
Published: September 2020

At present the genus Lygodactylus is represented by three species in Angola confirmed by voucher specimens—L. angolensis, L. bradfieldi, and L. capensis—and two others believed to be present, but without specimens with precise localities, L. chobiensis and L. lawrencei. We present a detailed taxonomic revision of the group in Angola and describe three new species, Lygodactylus baptistai sp. nov. L. nyaneka sp. nov. and Lygodactylus tchokwe sp. nov. Phylogenetic analysis using the mitochondrial marker ND2, as well as morphological data support the recognition of the new species. In addition, data suggest that specimens historically assigned to L. capensis in Angola represent misidentifications of L. nyaneka sp. nov. and L. tchokwe sp. nov. We revisit the identity of Lygodactylus laurae, a junior synonym of L. angolensis. We also present the first confirmed record of L. lawrencei in the country, using both morphological and molecular data. The description of the new species and the revision of the taxonomic identity of the Angolan populations of the genus, raises the number of species occurring in the country to five. A key to the Angolan species is presented.
A Nonlinear Multiscale Theory of Atmospheric Blocking: Eastward and Upward Propagation and Energy Dispersion of Tropospheric Blocking Wave Packets
Authors: Luo Dehai , Zhang Wenqi 
Published: September 2020

AbstractIn this paper, a nonlinear multiscale interaction model is used to examine how the planetary waves associated with eddy-driven blocking wave packets propagate through the troposphere in vertically varying weak baroclinic basic westerly winds (BWWs). Using this model, a new one-dimensional finite-amplitude local wave activity flux (WAF) is formulated, which consists of linear WAF related to linear group velocity and local eddy-induced WAF related to the modulus amplitude of blocking envelope amplitude and its zonal nonuniform phase. It is found that the local eddy-induced WAF reduces the divergence (convergence) of linear WAF in the blocking upstream (downstream) side to favor blocking during the blocking growth phase. But during the blocking decay phase, enhanced WAF convergence occurs in the blocking downstream region and in the upper troposphere when BWW is stronger in the upper troposphere than in the lower troposphere, which leads to enhanced upward-propagating tropospheric wave activity, though the linear WAF plays a major role. In contrast, the downward propagation of planetary waves may be seen in the troposphere for vertically decreased BWWs. These are not seen for a zonally uniform eddy forcing. A perturbed inverse scattering transform method is used to solve the blocking envelope amplitude equation. It is found that the finite-amplitude WAF represents a modified group velocity related to the variations of blocking soliton amplitude and zonal wavenumber caused by local eddy forcing. Using this amplitude equation solution, it is revealed that, under local eddy forcing, the blocking wave packet tends to be nearly nondispersive during its growth phase but strongly dispersive during the decay phase for vertically increased BWWs, leading to strong eastward and upward propagation of planetary waves in the downstream troposphere.
Splenic Primary Solid Tumors
Authors: Gonzalez-Urquijo Mauricio , Rodarte-Shade Mario , Gil-Galindo Gerardo 
Published: September 2020

Background The present study aims to present a case series of patients who underwent splenectomy for splenic primary solid tumors without preoperative histopathologic diagnosis. Methods From 2013 to 2019, 12 patients underwent splenectomy for solid primary splenic tumors at 3 different academic medical centers. All electronic medical records were retrospectively reviewed. Results Seven (58.3%) patients were women, and 5 (41.6%) were male. The median age was 48 years (range: 25-72 years). In 8 (66.6%) patients, a conventional approach was performed. In 2 (16.6%), a hand-assisted laparoscopic surgery procedure was completed, and in other 2 (16.6%) patients, a laparoscopic approach was auspiciously achieved. Median operative time was 135 minutes (range: 60-210 minutes), and median blood loss was 500 mL (range: 200-1500 mL). Procedure-related morbidity was found in 2 (16.6%) patients, and the mortality rate was 0%. The final histopathologic diagnosis was lymphoma in 5 (41.6%) patients, lymphangioma in 3 (25%) patients, hamartoma in 2 (16.6%) patients, angiosarcoma, and sclerosing angiomatoid nodular transformation (SANT) in 1 (8.3%) case each. Conclusion Splenectomy should be the treatment of choice when encountering a primary splenic tumor without the need for preoperative fine-needle aspiration biopsy, avoiding the complications this technique entails.
Prognostic value of serum aquaporin-1, aquaporin-3 and galectin-3 for young patients with colon cancer
Authors: Hong Yanyan , Chen Zhendong , Li Na , Zhang Mingjun 
Published: September 2020

Background This study aimed to investigate the long-term prognosis value of serum galectin-3, aquaporin (AQP)-1 and AQP-3 in young patients with colon cancer. Methods A total of 100 young patients with colon cancer, 100 cases of benign colon and 100 healthy people were collected. All colon cancer patients were followed up for 42 months. Results Compared with the benign lesion group and the control group, preoperative serum galectin-3, AQP-1 and AQP-3 concentrations were significantly increased in patients with colon cancer ( P <  0.05). The immunohistochemistry scores of galectin-3, AQP-1 and AQP-3 in colon cancer patients were positively correlated with serum galectin-3, AQP-1 and AQP-3 concentrations ( P <  0.05). Serum galectin-3, AQP-1 and AQP-3 concentrations were positively correlated with TNM staging (galectin-3: rPearson = 0.502, P <  0.001; AQP-1: rPearson = 0.415, P <  0.001; AQP-3: rPearson = 0.454, P <  0.001) and differentiation (galectin-3: rPearson = 0.377, P =  0.004; AQP-1: rPearson = 0.411, P =  0.001; AQP-3: rPearson = 0.483, P <  0.001). Receiver operator characteristic curve (ROC) analysis showed that the area under ROC curve (AUC) of the combination of galectin-3, AQP-1 and AQP-3 in distinguishing colon cancer was 0.907. The sensitivity in the parallel mode was 87.6%, and the specificity in the serial mode was 98.2%. Compared with the low galectin-3 group, low AQP-1 group and low AQP-3 group, the survival time of patients in the high galectin-3 group (χ2 = 13.929, P <  0.001), high AQP-1 group (χ2 = 10.157, P =  0.001) and high AQP-3 group (χ2 = 4.364, P =  0.037) were significantly shortened. Conclusion Galectin-3 combined with AQP-1 and AQP-3 had important value in the identification of young patients with colon cancer and was of great value in evaluating long-term prognosis.
A Retrospective Analysis of Blood Lead Levels in Newly Arrived Immigrant Children, Miami-Dade County, Florida, 2013-2016
Authors: Gwynn Lisa , Barash Ashley , Dave Devina J. , Koru-Sengul Tulay 
Published: September 2020

Objective The Centers for Disease Control and Prevention’s (CDC’s) recommendation for blood lead level (BLL) screening of refugee children is to test new arrivals aged 6 months to 16 years. No such recommendations exist for testing immigrant children. Our objective was to provide evidence in support of creating lower age-specific guidelines for BLL screening for newly arrived immigrant populations to reduce the burden of unnecessary BLL testing. Methods We conducted a 3-year (2013-2016) retrospective analysis of BLLs of 1349 newly arrived immigrant children, adolescents, and young adults aged 3-19 who visited the University of Miami Pediatric Mobile Clinic in Miami, Florida. We obtained capillary samples and confirmed values >5 μg/dL via venous sample. The primary outcome was BLL in μg/dL. The main predictor variable was age. We further adjusted regression models by poverty level, sex, and ethnicity. Results Of 15 patients with a BLL that warranted further workup and a lead level of concern, 9 were aged 3-5 and 6 were aged 6-11. None of the adolescent and young adult patients aged 12-19 had a lead level of concern. Nearly half of the patients (n = 658, 48.8%) lived in zip codes of middle to high levels of poverty. Conclusion This study provides evidence to support the creation of lower age-specific guidelines for BLL screening among newly arrived immigrant children and adolescents. Future studies should elucidate appropriate age ranges for BLL testing based on epidemiologic evidence, such as age and country of origin.
Life Course Pathway to Later-Year Depressive Symptoms: Multiple Mediation of Socio-Economic Status and Coping Resources by Gender
Authors: Lee Hyunjoo , Park Sojung , Kwon Eunsun 
Published: September 2020

Drawing on a life course and stress process perspective, this study examined the pathway from childhood SES to later year depressive symptoms, focusing on multiple life course SES and coping resources in old age. Data came from the 2006 and 2015 waves of the Korea Welfare Panel Study (KOWEPS). We selected respondents aged 51–55 in 2006 who were followed up when they were between 60 to 64 years of age in 2015. We merged the middle aged data in 2006 with the 2015 data when the respondents were 60–64 years of age ( N = 687). Phantom modeling was used to examine a multiple mediation pathway and multi-group analyses were conducted to examine the gender differences in the pathway. For older men, satisfaction with social/leisure activities was a significant coping resource, while, for older women, satisfaction with family relations was important.
Central Venous Catheter Insertion in the Prone Position—A Last Resort in Critically Ill COVID-19 Patients
Authors: Yang Michael X. , Ng Philip K. 
Published: September 2020

Background: In the setting of the COVID pandemic, many patients falling ill with acute respiratory distress syndrome eventually require prone positioning for gas exchange. Traditionally, central venous catheters are inserted with patient in the supine or Trendelenburg position. However, when a patient cannot tolerate supine position and the need for central venous access is urgent, catheter placement may be considered with the patient in the prone position. Case Summary: A 69-year-old male with rapidly declining respiratory status secondary to COVID pneumonia quickly developed acute respiratory distress syndrome, was rapidly intubated, and then placed in the prone position. Patient could not tolerate the supine position even briefly and required a central venous catheter insertion for continuous renal replacement therapy. We kept the patient in the prone position and successfully inserted a central venous catheter in such position with real-time ultrasound guidance and using micropuncture technique. Conclusion: In the setting of the COVID pandemic, many cases of acute respiratory distress syndrome require patients to be prone in order to improve gas exchange. In the most severe situations, these patients would not be able to tolerate rotating back to the supine position but would still require central venous catheter insertion urgently. We demonstrated feasibility of central venous catheter insertion in the prone position in these severely ill patients.
Geographical Mapping and Pattern of Referral of Cases of Perinatal Asphyxia Referred to a Tertiary Care Center in South India
Authors: Prathik B. H. , R. Kishore Kumar , Benakappa Naveen , Niranjan H. S. 
Published: September 2020

Introduction: Perinatal asphyxia is one of the leading causes of mortality and morbidity in neonates in developing countries. 1 The exact burden of asphyxia in not known in developing countries like India because of lack of robust data collection and monitoring. Most of the cases with moderate-to-severe asphyxia are referred to tertiary care centers for further management. Hence, this study was planned to know the burden of perinatal asphyxia from the place of referral. Objectives: The main objective of this study was to map the cases of perinatal asphyxia referred to a tertiary care hospital from the place of referral and to know the burden of asphyxia after this from the places of referral to plan educational interventions accordingly. Methods: It was a retrospective study conducted in a tertiary care center over a period of 3 years. A total of 388 neonates referred with perinatal asphyxia were analyzed from January 2015 to December 2017. Baseline characteristics, demographic and geographical data, pattern of referral, mode of transport, clinical outcome, morbidity and mortality patterns were analyzed. For the purpose of ease of analysis, possible dissemination of data, and fulfilling the need for intervention, the whole of Bangalore district was divided into different zones as per Bruhat Bangalore Mahanagara Palike (BBMP). The data were further mapped on the state map and the BBMP map. The analysis was done by standard statistical methods. Results: A total of 388 neonates were analyzed. Majority of cases were referred from Karnataka followed by Andhra Pradesh and Tamil Nadu. From our state most of them were from Bangalore Urban (43%) followed by Tumkur (14%), Bangalore Rural (11%), Chikkaballapur (10%), and Ramnagara (5.4%). In Bangalore, most of the asphyxia cases were from Bangalore South followed by Bangalore East and West. Males outnumbered females by nearly 30%. Nearly 80% of cases needed tactile stimulation and bag and mask ventilation. Resuscitation was carried out by doctors (70%) in majority of cases followed by nurses. In spite of having good ambulance service in our state, self-arranged ambulance was used in nearly 60% of cases for transport. The proportion of self-arranged ambulance remained higher even when analysis was made on the basis of districts and zones. Nearly 80% were successfully discharged with mortality rate being 5%. Conclusion: Geographical mapping showed that majority of the cases of perinatal asphyxia were from Bangalore South and East, and neighboring districts such as Tumkur, Bangalore Rural, and Chikkaballapur. Targeted training of health care workers, especially nurses in neonatal resuscitation in the areas of high mortality/morbidity, might reduce the incidence of perinatal asphyxia from these areas much quicker than focusing on urban areas only.
Assessment of Physical Growth and Motor Development of Preterm Babies Based on Developmental Assessment Scale For Indian Infants (DASII)
Authors: Akshara E. S. , Gohiya Poorva , Shrivastav Jyotsna 
Published: September 2020

Background: The rate of preterm births ranges from 5% to 18% across 184 countries. Almost 12% births are preterm in low-income countries compared with 9% in high-income countries. Almost 1 million children die each year due to complications of preterm birth. Of those who survive, suffer from face developmental disabilities and undernourishment. Aims and Objectives: To assess the physical growth and its relation with the development of babies taken into study. Materials and Methods: A prospective study was conducted on 159 preterm babies of gestational age 32 to 36 weeks. All the treatments given during hospitalization, course of stay, and special procedures done were recorded. Baby’s weight, length, and head circumference were again noted at the time of discharge. Anthropometric measurements were done at every follow-up visit. Neurodevelopmental screening was performed at each follow-up. At the end of 12 months the risk factors contributing to the delayed development were analyzed. Results: 95.5% infants born as preterm had a length of more than 58 cm (– 3SD) and weight 5.6 kg at 1 year and 50% infants had a head circumference of more than 39 cm (– 3SD). Conclusion: Preterm babies when followed-up for 1 year of age did attain appropriate weight and length of their corrected age. Microcephaly was observed in 30% of babies at 1 year of age, of which 15.7% were found with developmental delay.
Nurse-Led Neonatal Follow-Up Clinic: A New Emerging Concept in a Developing Country
Authors: Joshi Poonam , Sarojini Bindu , Joshi Meena , Thukral Anu 
Published: September 2020

Objective: To investigate the feasibility and acceptance of nurse-led neonatal follow-up clinic (NLNFC) in a tertiary care facility. Materials and Methods: In a prospective observational study, total 105 stable mother-neonate dyads were independently followed up in both nurse led and neonatologist run follow-up clinics. The outcome was measured in terms of agreement between the nurse and neonatologist in the domains of neonatal assessment, counselling mothers on essential newborn care (ENC) and giving advice ( P < 0.05) and mothers’ acceptability for NLNFC. Results: Agreement between the trained neonatal nurse and neonatologist varied between 87 and 100%. The most unanimity was observed in neonatal assessment and counselling on ENC (93.3%-100%) followed by prescribing treatment (87%). The mean acceptability scores of the mothers for NLNFC was 33.13 ± 2.6 (25-35, maximum possible score 35). Conclusion: Establishing NLNFCs in developing countries is feasible. Nurses can be entrusted with the responsibility of following up stable neonates here and mothers will surely be satisfied with this type of clinic.
Feeding of Low Birth Weight Neonates
Authors: Banait Nishanth , Basu Sriparna , Desai Prakash , Dutta Sourabh , Kumar Ashok , Kumar Jogender , Shenoi (Chairperson) Arvind , Suryawanshi Pradeep 
Published: September 2020

Nutrition in this critical period is essential for immediate outcomes such as changes in anthropometry (weight, length, and head circumference) as well as adverse effects like necrotizing enterocolitis. Nutrition also affects long-term adverse outcomes such as developmental delay, diplegic cerebral palsy, and death during infancy and childhood. This review has looked for the effects of nutrition in these areas. Further long-term outcomes like risk of adult onset diseases like myocardial infarction and stroke may also be related to the nutrition of the LBW neonate but have not been included in this review. The guideline has been developed using standard methods adapted by National Neonatology Forum in accordance with the process described in the World Health Organization handbook for guideline development. The detailed methods are described elsewhere in this compilation of guidelines. Table 1 summarizes the recommendations for practice questions prioritized by the guideline development group in consultation with a wider group of National Neonatology Forum members. The recommendations made by this group are summarized in Table 1 .
Talon Cusp Associates With MMP2 in a Cohort of Individuals Born With Oral Clefts
Authors: Cavalcante Bianca G. N. , Lacerda Rosa Helena W. , Assis Ionária O. , Bezamat Mariana , Modesto Adriana , Vieira Alexandre R. 
Published: September 2020

Objective: The aim of this study was to use dental development as a tool to subphenotype oral clefts and investigate the association of MMP2 with dentin-pulp complex anomalies, in order to identify dental anomalies that are a part of a “cleft syndrome.” Design: Two hundred and ninety individuals born with cleft lip and palate were evaluated and several clinical features, such as cleft completeness or incompleteness, laterality, and presence of dental anomalies were used to assess each individual’s cleft status. We tested for overrepresentation of MMP2 single nucleotide polymorphism rs9923304 alleles depending on individuals having certain dental anomalies. Chi-square and Fisher exact tests were used in all comparisons (α = .05). Results: All individuals studied had at least one dental anomaly outside the cleft area. Significant differences between individuals born with clefts with and without talon cusp ( P = .04) were observed for the frequency of the MMP2 less common allele. Conclusion: All individuals born with cleft lip and palate had alterations of the dentition, and a quarter to half of the individuals had alterations of the internal anatomy of their teeth, which further indicates that dental anomalies can be considered as an extended phenotype for clefts. MMP2 was associated with talon cusp in individuals born with oral clefts.
Real-world intensive safety monitoring of biosimilars rituximab and trastuzumab in a Portuguese oncology hospital
Authors: Mendes Diogo , Abrantes Joana , Rigueiro Graça , Pais Ana Filipa , Penedones Ana , Alves Carlos , Batel-Marques Francisco 
Published: September 2020

Purpose The aim of this study was to assess the safety profiles of two biosimilar medicines (rituximab and trastuzumab) in the treatment of cancer patients within a Portuguese oncology hospital. Methods This hospital-based prospective observational study followed a cohort event monitoring approach focused on signalling suspected adverse drug reactions (ADRs). Patients undergoing treatment with rituximab biosimilar CT-P10 (Truxima®) or trastuzumab biosimilar CT-P6 (Herzuma®) were recruited over an 11-month and a 6-month period, respectively. Clinicians identified eligible patients and used paper-based forms to report all ADRs associated with biosimilar medicines. ADR case reports were assessed for seriousness, expectedness and causality in the Pharmacovigilance Unit of Coimbra. Results Ninety-four patients received biosimilar medicines (rituximab, n = 35; trastuzumab, n = 59). Of those, 4 patients (11.4%) experienced 16 ADRs with rituximab and 1 patient (1.7%) experienced 5 ADRs with trastuzumab. All case reports contained serious and expected ADRs that were at least probably related with biosimilar medicines under study. Based on the MedDRA PT coding, the most reported ADR for rituximab CT-P10 was chest discomfort (n = 4; 19.1%), followed by odynophagia (n = 2; 9.5%). Trastuzumab CT-P6 was associated with back pain, headache, pain in extremity, tachypnoea and tremor (each, n = 1; 4.8%). Conclusion The results of this study suggest that using biosimilar rituximab and biosimilar trastuzumab to treat cancer patients in the real-world clinical setting is associated with acceptable safety profiles. No new safety problems were identified.
Suture and Fixation of the Transversalis Fascia during Robotic-Assisted Transabdominal Preperitoneal Hernia Repair to Prevent Seroma Formation after Direct Inguinal Hernia Repair
Authors: Pini Ramon , Mongelli Francesco , Proietti Francesco , Cianfarani Agnese , Garofalo Fabio , Di Giuseppe Matteo , La Regina Davide 
Published: September 2020

Background. Seroma formation after videoendoscopic repair of inguinal hernias, known as “pseudorecurrence”, may vary from an asymptomatic, self-limiting occurrence to a painful, chronic problem. The aim of this study was to investigate the incidence of postoperative seroma in robotic-assisted transabdominal preperitoneal hernia repair (R-TAPP), modified by suturing and fixating the transversalis fascia to the Cooper ligament. Methods. The study was approved by the local ethics committee (2019-01132 CE-3495). Patients undergoing R-TAPP for direct inguinal hernia from October 2017 to December 2019 were included. In all patients, a barbed running suture of the transversalis fascia was performed to close the cavity resulting from the direct hernia reduction and to fix it to the Cooper ligament, then a lightweight mesh was placed. Demographic and clinical data were collected and analysed. Results. Over the study period, 67 R-TAPP in 51 patients were identified. All patients were male, with a mean age of 63.1 ± 12.7 years. There was 1 case of conversion to open surgery due to adhesions of the caecum to the groin as a result of perforated appendicitis. The mean length of the hospital stay was 1.8 ± .6 days. After discharge, no cases of seroma or recurrence at 30 days nor chronic pain at a mean follow-up of 10.3 ± 6.8 months was detected. Conclusions. In the treatment of direct inguinal hernia with R-TAPP, suturing and anchoring the transversalis fascia to the Cooper ligament are safe, feasible and recommendable in order to prevent postoperative seromas.