bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation and improvement of emergency capacity of medical staff for the COVID-19: A cross-sectional study in China
Authors: Hu Shu-Xiao , Chen Chang-Fu , Liu Qing , Zhang Gao-Fei , Cheng Hua-Lin , Zhang Yan-Xin 
Published: August 2020

Abstract
Background: The coronavirus disease 2019 (COVID-19) has spread to 215 countries around the world. In the studies of responding to public health emergencies, most of them are focused on health systems, local governments or medical organizations, but less on individuals. Medical staff, however, are the core strength for responding to public health emergencies. The aims of this study are to investigate the status of medical staff’s emergency capacity during the Pandemic and to provide intellectual support for further enhancing the medical staff's ability to ensure the smooth operation of medical rescue. Methods: This study conducted a cross-sectional survey of four hospitals, which were designated to treat patients with COVID-19 in China. Based on the emergency capacity system for infectious diseases of medical staff, an improved Emergency Preparedness Information Questionnaire was used to evaluate the emergency capacity of medical staff. Linear regression and one-way analysis of variance were used to test the difference in the emergency capacity of medical staff; Spearman correlation analysis was used to study the correlation between self-efficacy and emergency capacity of medical staff. Results: The overall emergency capacity of the surveyed medical staff was at a medium level. There was a correlation between emergency capacity and age, working years, position, educational background and area where medical staff work. Emergency capacity was not related to the hospital grades. Emergency capacity was significantly related to whether medical staff had participated in frontline Pandemic prevention work. There was also a positive correlation between emergency capacity and self-efficacy of medical staff. Conclusions: The results highlighted the importance of the training mechanism for emergency personnel. The emergency input for public health emergencies should be increased to improve the emergency capacity of medical staff. In addition, it is necessary to pay attention to the mental health of medical staff.
Clinical pharmacist interventions in managing Key Monitoring Drugs in China
Authors: Yang Jing , Zheng Lei , Guan Yuyao , Zhang Xiaoli , Song Chao , Gu Yuchao 
Published: August 2020

Abstract
Background Drug-related problems (DRPs) are common in hospitalized patients using Key Monitoring Drugs. Clinical pharmacy services could minimize drug-related harm and improve patient care.Objective The aim of this study was to standardize the clinical application of Key Monitoring Drugs, reduce the Drug-related problems (DRPs) and drug costs by clinical pharmacist interventions.Methods Clinical pharmacist formulate management measures for Key Monitoring Drugs using evidence-based medicine and analyze the DRPs of Key Monitoring Drugs over a period of 5 years from 2015 to 2019. The drug cost and DRPs of Key Monitoring Drugs within five years after interventions by clinical pharmacist.Results In 2019, the total cost of the use of Key Monitoring Drugs decreased by 10.12 million CNY, in comparison to that in 2015. The proportion of revenue from Key Monitoring Drugs decreased by 11.49% from 2015 to 2019. The per capita drug cost of Key Monitoring Drugs gradually decreased, this resulted in a saving of 580.07 CNY from 2015 to 2019. The DRPs of Key Monitoring Drugs decreased by 45.50% from 2015 to 2019. Through administrative intervention, prescription review, information management, and pharmaco-economicevaluation, a scientific management system of Key Monitoring Drugs has been established, which can standardize the use of Key Monitoring Drugs and reduce their cost. Conclusion Clinical pharmacists’ interventions assisted in early detection Drug-related problems of Key Monitoring Drugs and prevention of the consequent patient harms.
Ultrafast imaging of spontaneous symmetry breaking in a photoionized molecular system
Authors: Li Min , Zhang Ming , Vendrell Oriol , Guo Zhenning , Zhu Qianru , Gao Xiang , Cao Lushuai , Guo Keyu , Su Qinqin , Cao Wei , Luo Siqiang , Yan Jiaqing , Zhou Yueming , Liu Yunquan , Lu Peixiang , Li Zheng 
Published: August 2020

Abstract
The Jahn-Teller effect is an essential mechanism of spontaneous symmetry breaking in molecular and solid state systems, and has far-reaching consequences in many fields. Up to now, to direct image the onset of Jahn-Teller symmetry breaking remains unreached. Employing ultrafast ion-coincidence Coulomb explosion imaging with sub-10 fs resolution, we unambiguously imaged the ultrafast dynamics of Jahn-Teller deformations of CH4+ cation in real space. It is unraveled that the Jahn-Teller deformation from C3v to C2v geometries takes a characteristic time of about 20 femtoseconds for this system. Classical and quantum molecular dynamics simulations agree well with the measurement, and reveal dynamics for the build-up of the C2v structure involving complex phasing process of multiple vibrational pathways of the CH4+ cation.
Gait Analysis of Healthy Rhesus Monkeys Using a Pressure-sensing Walkway System
Authors: Won Jinyoung , Kim Keonwoo , Yeo Hyeon-Gu , Park Junghyung , Seo Jincheol , Kim Yu Gyeong , Park Sung-Hyun , Choi Won Seok , Jeon Chang-Yeop , Lim Kyung Seob , Jeong Jinwoo , Choi Ji-Woong , Lee Youngjeon 
Published: August 2020

Abstract
Background: Gait analysis in non-human primate models has been performed to elucidate the neural systems involved in controlling quadrupedal locomotor behavior. This study aimed to use a pressure-sensing walkway to identify characteristics of species-specific quadrupedal locomotion in rhesus monkeys. A total of nine healthy adult female rhesus monkeys (Macaca mulatta) were used for gait analysis. We measured the temporo-spatial and kinetic parameters of quadrupedal gait using a custom-built pressure-sensing walkway and compared the left- and right-side parameters to assess the symmetry of the gait pattern. Results: All temporo-spatial and kinetic parameter values showed no significant differences among the nine rhesus monkeys for both the forelimbs and hindlimbs. However, significant differences were observed between forelimb and hindlimb kinetic parameters such as peak vertical force, vertical impulse, and the percentage of body weight distribution. All kinetic parameter values were higher for the forelimbs than for the hindlimbs. These data indicated that the center of gravity in healthy rhesus monkeys is located at the forelimbs rather than at the hindlimbs while walking. Furthermore, the symmetry indices considered for symmetric gait pattern showed a low variability. Most median symmetry index values were nearly zero, indicating no difference between the right and left sides. Conclusions: This study described valid methods for assessing gait parameters and demonstrated rhesus-specific characteristics of quadrupedal locomotion, providing a basis for the assessment of gait normality in rhesus monkeys.
Location Inference for Hidden Population with Online Text Analysis
Authors: Chuchu Liu , Ziqiang Cao , Xin Lu 
Published: August 2020

Abstract
Understanding the demographics of hidden population, such as men who have sex with men (MSM), sex workers, or injecting drug users, are of great importance for the adequately deployment of intervention strategies and public health decision making. However, due to the hard-to-access properties, e.g., lack of a sampling frame, sensitivity issue, reporting error, etc., traditional survey methods are largely limited when studying such populations. With data extracted from the very active online community of MSM in China, in this study we adopt and develop location inferring methods to achieve a high-resolution mapping of users in this community at national level. The performances of popular inference algorithms are compared to elucidate the most suitable approach. In addition, we propose a new hybrid model, which is proven to achieve the highest accuracy for inferring locations of online users only based on text content. This method is conducive to overcoming the sparse location labeling problem in user profiles, and can be extended to the inference of geo-statistics for other hidden populations.
Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates Methotrexate anticancer effects
Authors: Baquero Juan Miguel , Benítez-Buelga Carlos , Rajagopal Varshni , Zhenjun Zhao , Torres-Ruiz Raúl , Mueller Sarah , Hanna Bishoy Magdi Fekry , Loseva Olga , Wallner Olov , Michel Maurice , Rodríguez-Perales Sandra , Gad Helge , Visnes Torkild , Helleday Thomas , Benítez Javier , Osorio Ana 
Published: August 2020

Abstract
Background: The most common oxidative DNA lesion is 8-oxoguanine (8-oxoG) which is mainly recognized and excised by the glycosylase OGG1, initiating the Base Excision Repair (BER) pathway. Telomeres are particularly sensitive to oxidative stress which disrupts telomere homeostasis triggering genome instability. Methods: We used U2OS OGG1-GFP osteosarcoma cell line to study the role of OGG1 at the telomeres in response to oxidative stress. Next, we investigated the effects of inactivating pharmacologically the BER during oxidative stress (OS) conditions by using a specific small molecule inhibitor of OGG1 (TH5487) in different human cell lines. Results: We have found that during OS, TH5487 effectively blocks BER initiation at telomeres causing accumulation of oxidized bases at this region, correlating with other phenotypes such as telomere losses, micronuclei formation and mild proliferation defects. Besides, the antimetabolite Methotrexate synergizes with TH5487 through induction of intracellular ROS formation, which potentiates TH5487 mediated telomere and genome instability in different cell lines. Conclusions: Our findings demonstrate that OGG1 is required to protect telomeres from OS and present OGG1 inhibitors as a tool to induce oxidative DNA damage at telomeres, with the potential for developing new combination therapies for cancer treatment.
Allelic diversity of merozoite surface protein-1&nbsp;(MSP 1) and MSP 2 genes, and clinical manifestations of Plasmodium falciparum malaria cases in Aceh, Indonesia
Authors: Jamil Kurnia Fitri , Pratama Nandha Rizki , Marantina Sylvia Sance , Harapan Harapan , Kurniawan Muhammad Riza , Zanaria Tjut Mariam , Hutagalung Jontari , Rozi Ismail E , Asih Puji BS , Supargiyono Supargiyono , Syafruddin Din 
Published: August 2020

Abstract
Background
Malaria control programme in Indonesia has successfully brought down malaria incidence in many parts of the country, including Aceh Province. Clinical manifestation of reported malaria cases in Aceh varied widely from asymptomatic, mild uncomplicated to severe and fatal complications. The present study aims to explore the allelic diversity of merozoite surface protein genes among the P. falciparum isolates in Aceh Province and to determine their potential correlation with the severity of malaria clinical manifestation.
Methods
Screening of over 500 malaria cases admitted to the 11 districts hospital within Aceh Province during 2013–2015, identified 90 cases of P. falciparum mono-infection without any co-morbidity. The subjects were clinically phenotyped and parasite DNA was extracted and Polymerase Chain Reaction (PCR) amplified for the MSP1 and MSP2 allelic subfamilies.
Results
Analysis of clinical manifestation revealed that fever-chill is the most frequent symptom. Based on WHO criteria showed 19 cases classified as severe and 71 as mild malaria. Analysis of MSP 1 gene revealed the presence of K1 allele subfamily in 34 subjects, MAD20 in 42 subjects, RO33 in 1 subject, and mixed allelic of K1 + MAD20 in 5 subjects, K1 + RO33 in 4 subjects, and MAD20 + RO33 in 4 subjects. Analysis of MSP 2 gene revealed 34 subjects carried the FC27 allelic subfamily, 37 subjects (carried the 3D7 and 19 subjects carried the mixed FC27 + 3D7. Analysis of multiplicity of infection revealed that msp2 alleles is slightly higher than MSP 1 with the mean of MOI were 2.69 and 2.27, respectively. Statistical analysis to determine the association between each clinical manifestation and MSP 1 and MSP 2 alleles revealed that liver function abnormal value was associated with the MSP 2 mixed alleles (p < 0.05; odds ratio = 0.13; CI95%= 0.03–0.53). Malaria severity was associated with the mixed MSP 1 of K1 + RO33 with severe malaria (p < 0.05; odds ratio = 28.50; CI 95%= 1.59-1532.3).
Conclusion
This study found a strong association between severe malaria in Aceh with subjects carrying the MSP 1 mixed alleles of K1 and RO33. The liver function abnormal value associated with the MSP 2 mixed allelic subfamilies. Further study in different geographic areas is recommended.
Local low-rank approach to nonlinear-matrix completion
Authors: Sasaki Ryohei , Konishi Katsumi , Takahashi Tomohiro , Furukawa Toshihiro 
Published: August 2020

Abstract
This paper deals with a problem of matrix completion in which each column vector of the matrix belongs to a low-dimensional differentiable manifold (LDDM), with the target matrix being high or full rank. To solve this problem, algorithms based on polynomial mapping and matrix-rank minimization (MRM) have been proposed; such methods assume that each column vector of the target matrix is generated as a vector in a low-dimensional linear subspace (LDLS) and mapped to a p-th order polynomial, and that the rank of a matrix whose column vectors are d-th monomial features of target column vectors is deficient. However, a large number of columns and observed values are needed to strictly solve the MRM problem using this method when p is large; therefore, this paper proposes a new method for obtaining the solution by minimizing the rank of the submatrix without transforming the target matrix, so as to obtain high estimation accuracy even when the number of columns is small. This method is based on the assumption that an LDDM can be approximated locally as an LDLS to achieve high completion accuracy without transforming the target matrix. Numerical examples show that the proposed method has a higher accuracy than other low-rank approaches.
The interaction of water with archeological birch bark and its effects on swelling, shrinking and deformations
Authors: Klügl Johanna , Pietro Giovanna Di 
Published: August 2020

Abstract
In this paper we present results of water sorption of archaeological, ethnographical and contemporary birch bark and of the water-induced size and shape changes during humidification and drying. The analysis revealed that the equilibrium moisture content is higher if lenticels or inner bark are present and that the burial context influences the sorption behavior: the better the preservation condition of the archaeological birch bark, the lower the equilibrium moisture content. Compared to other organic materials like wood, the water uptake and the related swelling of outer birch bark is modest. This can be attributed to the cell structure and composition: outer birch bark is composed of closed cells made to a large extent of hydrophobic components (suberin, lignin). We show that warping of the bark takes place at high moisture content. This deformation is related to the plasticization effect of water and to the release of the built-in tension related to the stretching of the cells during the tree’s growth. Our results provide a first guidance to conservators in the decision of water treatments on birch bark objects.
Association Between Intimate Partner Violence During Pregnancy And Birth Asphyxia In Hospitals Of Tigray Region, Ethiopia
Authors: Gebreslasie Kahsay , Gebre Gelawdiwos , Zenebe Dawit , Weldemariam Solomon , Mehari Mehret Ab , Nardos Rahel , Birhanne Akilil 
Published: August 2020

Abstract
Background: Birth asphyxia is the main causes of neonatal mortality and morbidity worldwide. Some studies indicate intimate partner violence during pregnancy is a risk factor for birth asphyxia. In Ethiopia, intimate partner violence is reported in nearly 26 percent of pregnancies. Despite this high prevalence, there is lack of data about the association of birth asphyxia and intimate partner violence. The aim of this study was to assess the prevalence of intimate partner violence during pregnancy and its associated factors with birth asphyxia in health facilities in the Tigray region of northern Ethiopia. Methods: This was an institutional based cross-sectional study conducted at select health facilities in the Tigray region of Ethiopia. Random sampling technique was employed to select health facilities and systematic sampling was used to select the study participants. Data was entered by using Epi info version 3.5.1 and was analyzed using SPSS version 20. Bivariate and multivariate analysis was done to assess the association between exposure to intimate partner violence during pregnancy and birth asphyxia after adjusting for possible confounders. Results: The prevalence of intimate partner violence during pregnancy was 7.3%. Eighty two (12.7%) babies were delivered with birth asphyxia. Intimate partner violence during pregnancy had significant association with birth asphyxia AOR (95% CI) =4.4(2-9.8). In addition to this residence, AOR (95% CI) =2.7(1.55-4.8), age>19,AOR (95% CI) =2.9(1.29-6.5), age 20-35, AOR (95% CI) =3.1(1.06-9.3), gestational age<37 weeks, AOR(95% CI)=7.2(3.5-14.8) and low birth weight, AOR(95% CI)=3.9(2.1-7.3) had significant association with birth asphyxia.Conclusions: The prevalence of birth asphyxia in this study is high. Women who experienced intimate partner violence during pregnancy increased the risk of birth asphyxia.
The Effect of Vertebral Venous Collaterals on Intracranial Hypertension and Related Symptoms in Patients with Bilateral Transverse Sinus Stenosis
Authors: Li Min , Bai Chaobo , Sun Jingkun , Xia Ning , Meng Ran , Ji Xunming 
Published: August 2020

Abstract
Background: Vertebral venous collaterals (VVC) were often found in patients with bilateral transverse sinus stenosis (BTSS). The purpose of this study was to investigate the physiological role of VVC in BTSS patients.Methods: The index of TSS was used in the assessment of BTSS severity. Subjects underwent a standard lumbar puncture to measure the intracranial pressure (ICP). Papilledema and tinnitus were evaluated by using Frisén's grade and questionnaires for tinnitus handicap inventory (THI), respectively. The intensity and impact of headache was assessed by using 10-point Numeric Pain Rating Scale (NPRS) and six-item Headache Impact Test (HIT-6).Results: BTSS group had more patients with severe intracranial hypertension (IH) and less patients with normal ICP. BTSS patients had higher ICP than normal controls. Further analysis on VVC showed that VVC decreased the elevated ICP in BTSS patients and exerted no impact on ICP in normal controls. A similar incidence of VVC in BTSS patients and normal controls were found. BTSS patients with normal ICP and mild IH exhibited a higher incidence of VVC compared with those with severe IH. VVC, rather than the severity of BTSS, regulated the ICP. Furthermore, VVC alleviated IH-related clinical manifestations including papilledema and tinnitus in BTSS patients.Conclusions: The present study demonstrated BTSS is correlated with IH. The presence of VVC, which is postulated to be congenitally formed, normalizes the elevated ICP and alleviated IH-related symptoms in BTSS patients. VVC may be used as an indicator of relatively low ICP in BTSS patients.Trial registration: This study was registered retrospectively on 07/28/2020 (NCT04492332).
Morita-Baylis-Hillman Reaction Inspired [3,3]-Rearrangement of Aryl Iodanes with α,β-Unsaturated Oxazolines
Authors: Zhang Lei , Bao Wangzhen , Liang Yuchen , Pan Wenjing , Li Dongyang , Kong Lichun , Wang Zhi-Xiang , Peng Bo 
Published: August 2020

Abstract
The [3,3]-rearrangement of aryl iodanes with α,β-unsaturated oxazolines has been developed by merging Morita-Baylis-Hillman (MBH) process into the rearrangement reaction. The method allows for the exclusively E-selective synthesis of a wide variety of valuable α-aryl α,β-unsaturated oxazolines which can be difficult to synthesize with other known methods. Experimental and computational mechanistic studies unraveled that the reaction proceeds via the assembly of both coupling partners followed by MBH-type addition to form rearrangement precursor, [3,3]-rearrangement, and stepwise E1cb-elimination. The E-selectivity of the reaction is favored both kinetically and thermodynamically.
Cohort profile: Why do people keep hurting their back?
Authors: Klyne David Murray , Hoorn Wolbert van den , Barbe Mary Frances , Cholewicki Jacek , Hall Leanne , Khan Asad , Meroni Roberto , Moseley G. Lorimer , Nicholas Michael , O'Sullivan Lee , Park Rachel , Russell Glen , Sterling Michele , Hodges Paul William 
Published: August 2020

Abstract
Objective Low back pain (LBP) is one of the most disabling and costly conditions worldwide. It remains unclear why many individuals experience persistent and recurrent symptoms after an acute episode whereas others do not. A longitudinal cohort study was established to address this problem. We aimed to; (1) evaluate whether promising and potentially modifiable biological, psychological, social and behavioural factors, along with their possible interactions, predict LBP outcome after an acute episode; (2) compare these factors between individuals with and without acute LBP; and (3) evaluate the time-course of changes in these factors from LBP onset. This paper outlines the methodology and compares baseline characteristics between acute LBP and control, and LBP participants with and without follow-up.Results 133 individuals with acute LBP and 74 pain-free individuals participated. Bio-psycho-social and behavioural measures were collected at baseline and 3-monthly for 12 months (LBP) or 3 months (control). Pain and disability were recorded fortnightly. Baseline characteristics were mostly similar between those who did and did not return for follow-up. Initial analyses of this cohort have revealed important insights into the pathways involved in acute-to-chronic LBP. These and future findings will provide new targets for treatment and prevention of persistent and recurrent LBP.
Local Efficacy of Corticosteroids as an Adjuvant for Periarticular Cocktail Injection in Simultaneous Bilateral Total Knee Arthroplasty: A Prospective Randomized Double-blind Controlled Trial
Authors: peng huiming , wang wei , lin jin , weng xisheng , qian wenwei , wang wenda 
Published: August 2020

Abstract
Background: Multimodal cocktail periarticular injection(MCPI) including corticosteroids is currently widely applied to reduce postoperative pain and swelling following total knee arthroplasty (TKA). However the addition of steroids is controversial.This prospective, double-blinded, randomized, controlled trial compares the safety and efficacy of MCPI with or without corticosteroids.Methods: A total of 60 patients (120 knees) who underwent simultaneous bilateral TKAs received periarticular injections with added betamethasone (7mg) in a randomly selected knee, and the other knee was injected without added corticosteroids. The visual analog scale(VAS) pain scores at rest and in motion, range of motion (ROM), thigh swelling, hospital for special surgery(HSS) score, and adverse events were compared between the 2 knees.Results: There were no statistically significant differences in the visual analog scale score, ROM, thigh girth, HSS score, and complications between the 2 kness. The patients were unable to detect a difference in the functional recovery between their knees on postoperative day 3or at the 3 month follow-up.Conclusion: Betamethasone injections are ineffective locally for relieving pain, reducing swelling, and improving the postoperative ROM.Trial registration: Chinese Clinical Trial RegistryNumber: ChiCTR-OPC-17013503, Date of Registration: 2017-11-23 URL:http://www.chictr.org.cn/showproj.aspx?proj=23146