bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatial Estimation of Soil Erosion Using RUSLE Modeling: A case study of Dolakha District, Nepal
Authors: Thapa Pawan 
Published: June 2020

Abstract
Background: In the mountainous areas, soil erosion causes the topsoil loss which decreases fertility in the agricultural land. Spatial estimation of soil erosion essential for an agriculture-dependent country like Nepal for developing erosion control plans. This study was conducted for estimation of soil erosion impacts on Dolakha using the Revised Universal Soil Loss Equation (RUSLE) model, also analyzes the effect of Land Use and Land Cover (LULC) on soil erosion.Results: The soil erosion rate had been categorized into 6 erosion classes based on the erosion severity, and 5.01% of the areas was found to be under extreme severe erosion risk (> 80 Mg ha-1yr-1) that should be addressed by decision-maker for reducing its rate and consequences. Followed by 10 % areas were classified under high to severe with the rate of soil loss range from 10 to 80 Mg ha-1yr-1. While 15% and 70% of areas remained in moderate and low-risk zone respectively. The results suggest this district northeastern part suffers from a high soil erosion risk due to steep slope.Conclusions: The result produces a spatial distribution of soil erosion over Dolakha, which can be applied for conservation and management planning processes, at the policy level, by land-use planners and decision-makers.
Statistical Joint Modeling on Longitudinal Body Weight and CD4 Cell Progression with Survival Time-to-Death Predictors on HIV/AIDS Patients in Mekelle General Hospital, Ethiopia.
Authors: Gebrerufael Gebru , Asfaw Zeytu , Melese Dessie 
Published: June 2020

Abstract
Background

This study assessed the impact of repeated biomarker measurements of statistical joint modeling on survival time-to-death and determines potential predictors of HIV/AIDS patients on ART in Mekelle General Hospital Ethiopia.
Methods

A retrospective cohort study was conducted among HIV/AIDS patients who were under ART follow-up during September 11, 2013 - September 5, 2016 at Mekelle General Hospital, Ethiopia. The two repeated biomarkers of longitudinal measurements and survival outcome with separate

univaraite
longitudinal modeling approach and statistical joint modeling approach were used to fit simultaneously. A total of 216 HIV/AIDS patients were selected by using systematic random sampling technique from ART follow-up.
Results

The relationship between the two biomarkers CD4 cell and body weight with risk for survival time-to-death were statistical insignificant. Thus, death is less probable to occur in HIV/AIDS patients with higher value of CD4 cell count and body weight progression. In event process the sub-model, Baseline CD4, Fair and Good Adherence, HIV/TB (yes) and Sex (male) were significant factors of risk to short survival Time-to-Death on HIV/AIDS patients. In the 1st longitudinal process sub-model, Baseline CD4, Ambulatory functional status, HIV/TB (yes), Time*Ambulatory functional status, Time*Working functional status and Time*Baseline CD4 were the significant factors of

\sqrt{CD4 cell }
count progression. Moreover, In 2nd longitudinal process sub-model, visit Time of follow-up, Age, Sex (male), Baseline weight, Time*Ambulatory and Time*Working functional status were the significant factors of log 10(body weight) progression.
Conclusion

Both governmental and non-governmental stakeholders should pay special attention for HIV positive adults, especially for those who had developed HIV/TB, male, bedridden functional status, poor adherence and lower Baseline CD4 cell count progression so that mortality due to HIV/AIDS optimally reduced.
Prevalence and Associated Factors of Intestinal Parasites in Ethiopian Ortodox Tewahido Church Religious Students, Ethiopia
Authors: Addisu Ayenew , Gebre Habtamu , Tesfaye Sara , Zewdu Mola , Birhanie Meseret 
Published: June 2020

Abstract
Background

Intestinal parasitic infections are the most serious medical and public health problems in developing countries. In Ethiopia, intestinal parasites are among the top ten causes of morbidity, especially in children. The aim of this study was to assess the prevalence and associated factors of intestinal parasites among Ethiopian Orthodox church school students in Gondar town, northwest Ethiopia.
Method:

an institutional-based cross-sectional study was conducted to assess the prevalence and associated factors of intestinal parasites among religious students in Gondar town from February 2019 to April 2019, northwest Ethiopia. A total of 360 participants were selected by the random sampling technique.
Results

In this study, a total of 360 Orthodox Tewahido church school students were participated. The over all parasite prevalence, 24.7% was relatively low compared with previous studies conducted in other localitie in Ethiopia. The predominanat parasites were A. lumbricoides S. mansoni and hookworm with (11.4%), (4.4%) and (3.6%) prevalence respectively, A significant association was observed among participants with habits of frequent swiming with 2.3 times higher probability of acquaring infections, but there was no association with gender, age, finger nail status, the habit of eating uncooked vegetables/ fruits, source of drinking water and proper toilet utilization.
Conclusion

In general, the prevalence of intestinal parasite infections was high and calls for intervention actions on Orthodox Tewahido church students. Moreover, swimming frequency and habits had a significant association. Since the prevalence was high, improvement in awareness and enhancing health seeking behavior of the students, deworming and health education need to be focused on.
Clinical features and neuropsychiatric comorbidities in pediatric patients with tic disorders
Authors: Park Eu Gene , Kim Young-Hoon 
Published: June 2020

Abstract
Background
Tic disorders are childhood-onset neuropsychiatric disorders characterized by multiple motor or vocal tics with frequent comorbidities and a broad spectrum of phenotypic presentations. In this study, we aimed to investigate the clinical characteristics and comorbid neuropsychiatric conditions in pediatric patients with tic disorders.
Methods
We retrospectively reviewed the medical records of 119 pediatric patients (89 males, 30 females) who were diagnosed with tic disorders according to the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-Ⅴ) at Uijeongbu St. Mary’s Hospital, Republic of Korea, between January 2012 and July 2019. Statistical comparisons were performed using Fisher’s exact test, Pearson’s chi-square test, Student’s t-test, and the Kruskal-Wallis test. Spearman’s rank correlation coefficient was used to conduct correlational analyses.
Results
The mean age of tic onset was 6.9 years (range, 1–14) and the mean age at diagnosis was 8 years (range, 1–17). The mean lag between tic onset and diagnosis was 13.3 months (range, 0.25–132). The most common, first-presenting tics were eye blinking (50.4%), followed by jaw or lip movement (29.4%) and throat clearing (29.4%). Thirty-seven (31.1%) patients had at least one co-occurring neuropsychiatric disorder at the time of tic diagnosis. Subtypes of tic disorders, types of first-presenting tics, and presence of neuropsychiatric comorbidities were not associated with tic severity. Tic severity was associated with greater functional impairment and tic noticeability (P < 0.05). A relatively shorter time to diagnosis was associated with tic severity (Spearman’s ρ = − 0.147, P = 0.110).
Conclusions
The evolving nature of tic expression and severity, high prevalence of neuropsychiatric comorbidities, and associated functional impairments emphasize the importance of comprehensive assessment during the disease course for determining and prioritizing goals of treatment.
Overexpression of miR-146a-5p alleviate SDF1-induced cartilage degradation through repression TRAF6 mediated p38-MAPK signal pathway
Authors: Wang Guoliang , Yang Xiao , Xiang Yaoyu , He Lu , Jia Di , Li Yanlin 
Published: June 2020

Abstract
Background : Previous study have revealed that miR-146a-5p has a role in osteoarthritis (OA) development, here, we aim to further explore the underlying mechanism of miR-146a-5P in OA both in vitro and in vitro . Methods : RT-PCR was used to detect the level of miR-146a-5p in OA patients. Primary chondrocytes were treated with SDF-1 to induce an OA model in vitro , and an IL-1β mediated OA model in rats were also used. Gain- or loss- of function assays of miR-146a-5p and TRAF6 were conducted to determine their roles in regulating the proliferation, apoptosis and cartilage degradation of chondrocytes. Results : MiR-146a-5p was overexpressed in OA patients while downregulated in SDF-1 treated chondrocytes. Functionally, miR-146a-5p considerably accelerated the proliferation, inhibited apoptosis and limited ECM degradation of SDF-1 induced chondrocytes. However, TRAF6 upregulation had the opposite effects. Moreover, miR-146a-5p also inhibited OA progression in vivo. Mechanistically, miR-146a-5p targeted at the 3’UTR of TRAF6 and relieved TRAF6 mediated p38-MAPK/NF-κB activation. Conclusions : MiR-146a-5p exerted protective effects chondrocytes against SDF-1 or IL-1β induced OA by regulating the proliferation, apoptosis and ECM degradation of chondrocytes by regulating the TRAF6/ p38-MAPK signaling pathway.
A Bibliometric Analysis of Folate Receptor Research: A comprehensive bibliometric analysis of the entire field of Folate Receptor Research
Authors: Didion Cari , Henne Walter 
Published: June 2020

Abstract
Background
The objective of this study is to conduct a comprehensible bibliometric analysis of the entire field of folate receptor research.
Methods
A Web of Science search was performed on folate receptor or folate binding protein (1969-to June 28, 2019). The following information was examined: publications per year, overall citations, top 10 authors, top 10 institutions, top 10 cited articles, top 10 countries, cc-author collaborations and key areas of research.
Results
In total, 3248 documents for folate receptor or folate binding protein were retrieved for the study years outlined in the methods section search query. The range was 1 per year in 1969 to 264 for the last full year studied (2018). A total of 123,720 citations for the 3,248 documents retrieved represented a mean citation rate per article of 38.09 and range of 1667 citations (range 0 to 1667). Researchers in 71 countries authored publications analyzed in this study. The US was the leader in publications and had the highest ranking institution. The top 10 articles have been cited 7270 times during the time frame of this study. The top cited article had an average citation rate of 110 citations per year. Network maps revealed considerable co-authorship among several of the top 10 authors.
Conclusion
Our study presents several important insights into the features and impact of folate receptor research. To our knowledge, this is the first bibliometric analysis of folate receptor.
The Axin2-snail Axis Promotes Bone Invasion by Activating Cancer-associated Fibroblasts in Oral Squamous Cell Carcinoma
Authors: An Yin-Zhe , Cho Eunae , ling Junqi , Zhang Xianglan 
Published: June 2020

Abstract
Background: In bone-invasive oral squamous cell carcinoma (OSCC), cancer-associated fibroblasts (CAFs) infiltrate into bony tissue ahead of OSCC cells. In the present study, we aimed to investigate the role of the Axin2-Snail axis in the biological behavior of CAFs and bone invasion in OSCC.Methods: The clinicopathological significance of Axin2 and Snail expression was investigated by immunohistochemistry in an OSCC cohort containing 217 tissue samples of patients with long-term follow-up. The influence of the Axin2-Snail axis on the biological behavior of OSCC cells and CAFs was further investigated both in vitro and in vivo.Results: Axin2 expression is significantly associated with Snail expression, status of desmoplasia, and bone invasion in patients with OSCC. In multivariate analysis, lymph node metastasis, desmoplasia, Axin2, and Snail expression were independent poor prognostic factors in our cohort. Supportively, OSCC cells demonstrated attenuated oncogenic activity as well as decreased expression of Snail and various cytokines after Axin2 knockdown in vitro. Among the related cytokines, C-C motif chemokine ligand 5 and interleukin 8 have a strong influence on the biological behavior of CAFs in vitro. Moreover, both the desmoplastic reaction and osteolytic lesions in the calvaria were predominantly decreased after Axin2 knockdown in OSCC cells in vivo using BALB/c athymic nude mice xenograft model. Conclusions: Oncogenic activities of the Axin2-Snail axis are not limited to the cancer cells themselves, but rather extend to CAFs by regulation of cytokine-mediated cancer-stromal interaction, with further implications for bone invasion as well as poor prognosis of OSCC.
Identification and Functional Analysis of Serum Specific MiRNAs in Recurrent Aphthous Somatitis Patients With Excess-heat or Yin-deficiency
Authors: Bao Jie , Zhu Zhengyang , Zhang Xizhao , Huang Lin , Xu Li , Dou Xiaobing , Fan Yongsheng 
Published: June 2020

Abstract
Background:To identity key miRNAs as signatures for recurrent aphthous stomatitis(RAS)with Excess-heat or Yin-deficiency bymiRNA microarrays. Method: Serum samples were collected from patients meeting the RAS diagnostic criteria of excess-heat oryin-deficiencysyndrome and healthy individuals. CoremicroRNAs (miRNAs) were then identified under miRNA microarray analyses. Target prediction and bioinformatic analyses were carried out andgene-pathway-networks werevisualized to better understand the relationship between differentgenes and pathways.Result:(1) 90 individuals meeting the inclusion criteria were collected in this study, of which 30 were normal control, 30 were patients of excess-heat syndrome and the rest were patients ofyin-deficiency syndrome. Among them, 9 miRNAs werescreened out in excess-heat syndrome group, with 1 upregulated and 8 downregulated. And four randommiRNAs(hsa-miR-20b-5p, hsa-miR-122-5p, hsa-miR-483-5p and hsa-miR-3197) were validatedby real-time PCR method. 14 miRNAs werescreened out in yin-deficiency syndrome group(7 upregulated and 7 downregulated). And hsa-miR-17-5p, hsa-miR-106-5p and hsa-miR-20b-5p were validated. (2)A total of 4776 target genes were identified for the validated 9 miRNAs in excess-heat syndrome group.These targets were enriched inGO categories including nervous system development, homophilic cell adhesion via plasma membrane adhesion molecules, and calcium ion binding and KEGG pathway such as proteoglycans in cancer, P13K-AKT signaling pathway and Calcium signaling pathway. 10172 target genes were identified for the validated 14 miRNAs in yin-deficiency syndrome group. The enrichedGO categories included protein binding, positive regulation of transcription from RNA polymerase II promoter and membrane andenrichedKEGG pathway included pathways in cancer, MAPK signaling pathway and Ras signaling pathway.Conclusion:Hsa-miR-20b-5p in patients with RAS could act as the novel target for syndromeclassification of the disease. It is upregulated in RAS patients with excess-heat syndrome while downregulated in patients with yin-deficiency syndrome. The PI3K-Akt signaling pathway and MAPK signaling pathway and related target genes may provide new insights into the molecular mechanisms of RAS with excess-heat syndrome or yin-deficiency syndrome, respectively.
Predictors of adolescents’ use of sexual and reproductive health services in Nigeria: a mixed-method approach
Authors: Odo Amelia Ngozi , OFUEBE Justina Ifeoma , ANIKE Anthony Ifeanyi , Samuel Efiong S 
Published: June 2020

Abstract
Sexual and Reproductive health Services (SRHS) are essential for prevention and control of SRH problems among adolescents and the achievement of sustainable development goal 3. These services may be available but certain factors interfere with their access and utilization by the adolescents. This study sought to determine factors that predict adolescents’ utilization of SRHS in Enugu State, Nigeria.MethodsThe study adopted mixed method research employing cross-sectional research design. The population of the study comprised adolescents (12-22 years). Multi-stage sampling procedure was used to select 1,447 adolescents used for the study. Questionnaire, in-depth interview and focus group discussion were used for data collection. Percentages, Chi-square, and logistic regression were used to analyse quantitative data, while qualitative data were thematically analysed using NVivo software.ResultsSocio-demographic factors of gender, age, education, location and living status (p = < .05) were significant predictors of utilization of SRHS. Psycho-cultural and health system factors (p = < .05) were also significant predictors of utilization of SRHS.ConclusionThe study concluded that some socio-demographic, psycho-cultural and health system factors are predictors of adolescents’ access to and utilization of SRHS. These predictors could be addressed through home sex education, regular training of health care providers on youth-friendly services delivery and policy reforms
Women’s Experiences of Safety Apps for Sexualized Violence: A Narrative Scoping Review
Authors: Doria Nicole , Ausman Christine , Wilson Susan , Consalvo Annalisa , Sinno Jad , Numer Matthew 
Published: June 2020

Abstract
Background
Sexualized violence against women is a significant human rights problem worldwide. Safety apps have the capacity to provide women with resources to prevent or respond to experiences of sexualized violence. The aim of the following study was to review the scope of the literature on women’s experiences of safety apps related to sexualized violence and identify if there is a current gap in this literature.
Methods
This scoping review employed a systematic methodology guided by the Arksey and O’Malley framework. The search for this scoping review was conducted in January 2020 and four electronic databases were searched: Embase, MEDLINE, PsycINFO, and Scopus. Reference lists of systematic reviews, scoping reviews, and literature reviews that were found through the search of databases were also checked to ensure all relevant studies had been screened. Last, the table of contents for the last five years (2015–2020) were hand searched in four key journals (Journal of Technology in Human Services, Violence Against Women, BMC Public Health, and Health Promotion International) to identify any articles that may have been missed in the database search. Covidence was used to complete the screening. All data that met inclusion criteria was charted, extracted and synthesized.
Results
Across the four databases searched, a total of 389 studies were identified; 127 duplicates were removed, resulting in 262 studies screened. In total, 6 studies were included from the search of databases and 1 study was included from hand-searching, for a total of 7 included studies. Thematic analysis identified the following themes in the literature, which are summarized narratively: (1) security; (2) accessibility; and (3) knowledge. Recommendations and barriers found in relation to each theme are also presented.
Conclusions
This review confirms that the qualitative literature on women’s experiences of sexualized violence safety apps is scarce and exposes that a gap in the literature on this topic. The gaps in the literature were identified and implications and recommendations for future research are discussed.
Analysis of the changes in the lacrimal system before and after endoscopic dacryocystorhinostomy
Authors: Li Sha , Zheng Yijun , Zhang Yong , Chen Lin 
Published: June 2020

Abstract
BackgroundWe aimed to analys and explore the changes in the lacrimal system before and after endoscopic dacryocystorhinostomy (EN-DCR).MethodsA series of case studies was reviewed. The clinical data of 104 patients (120 eyes) who underwent EN-DCR in our hospital from March 2019 to October 2019 were selected for the study. The tear meniscus height (TMH) and the Schirmer I test (SIt) values were compared preoperatively and 1 month and 3 months postoperatively and statistically analysed by Mauchly's test of sphericity and the Pearson correlation coefficient.ResultsThe TMH decreased across all 3 timepoints, and the differences were statistically significant (P<0.05). The TMH values were measured 3 times in 120 eyes and showed three patterns: increased steadily (34 eyes), descended first and then ascended (32 eyes), and decreased steadily (54 eyes); the changes in the three patterns were statistically significant (P<0.05). There were a significant increases in SIt values among the three timepoints, and the SIt values gradually increased when the SIt values were < 10 mm/5 min preoperatively. However, there was no significant difference in SIt values when the SIt values were ≥ 10 mm/5 min preoperatively. The TMH was highly correlated with the SIt value preoperatively (r = 0.763), moderately correlated at 1 month postoperatively (r = 0.515), and not correlated at 3 months postoperatively (r = 0.097).ConclusionsEN-DCR has a certain degree of influence on the tear system, which is not only reflected in the tear drainage system, but also in the tear secretion system and the interaction between the two systems; however, excess tear drainage, can also alleviate dry eyes.Funding programmeJoint Fund Project of Hubei Provincial Health Select Committee (No. WJ2019H318); General Key Projects of Medical Research in Wuhan City, Hubei Province (No. WX19A03)