bluuebunny/crossref_metadata_2025_split huggingface dataset:
Senkyunolide&nbsp;I Protects Against Sepsis-associated Encephalopathy by Attenuating Sleep Deprivation in a Murine Model of Cecal Ligation and Puncture
Authors: Xie Jian , Zhao Zhen-zhen , Li Peng , Zhu Cheng-long , Guo Yu , Wang Jun , Deng Xiao-ming , Wang Jia-feng 
Published: December 2020

Abstract
Background: Sepsis may lead to sleep deprivation, which will promote the development of neuroinflammation and mediate the progression of sepsis associated encephalopathy (SAE). Senkyunolide I, an active component derived from an herb medicine, has been shown to provide sedative effect to improve sleep. But its role in sepsis is unclear. The present study was performed to investigate whether Senkyunolide I protected against SAE in a murine model of cecal ligation and puncture (CLP).Methods: The male C57BL/6 mice were used to investigate the effects of Senkyunolide I on SAE. The related protein of the sleep deprivation and inflammatory signaling pathway was detected by western blot. The activation of microglia and the neuronal apoptosis were separately detected by immunofluorescence staining and TUNEL staining.Results: Here, we showed that Senkyunolide I treatment improved the 7-day survival rate and reduced the excessive release of cytokines including TNF-α, IL-6 and IL-1β. A fear conditioning test was performed and the result showed that Senkyunolide I attenuated CLP-induced cognitive dysfunction. Senkyunolide I treatment also decreased the phosphorylation levels of inflammatory signaling proteins, including p-ERK, p-JNK, p-P38, p-P65, and the level of inflammatory cytokines, including TNF-α, IL-6 and IL-1β, in the hippocampus homogenate. The sleep deprivation was attenuated by Senkyunolide I administration, as demonstrated by the modification of the BDNF and c-FOS expression. When sleep deprivation was induced manually, the protective effect of Senkyunolide I against inflammatory responses and cognitive dysfunction was reversed. Conclusion: Our data demonstrated that Senkyunolide I could protect against sepsis-associated encephalopathy in a murine model of sepsis via relieving sleep deprivation.
All-dielectric Phase-gradient Metasurface Performing High-efficiency Anomalous Transmission in the Near-infrared Region
Authors: Wu Tiesheng , Liu Zhihui , Wang Yiping , Zhang Huixian , Yang Zuning , Yang Dan 
Published: December 2020

Abstract
We propose and numerically demonstrate a phase-gradient metasurface with high anomalous transmission efficiency and great anomalous refraction angle, which consists of discontinuous regular hexagonal nanorods supported by a quartz substrate. The metasurface achieves high anomalous transmission efficiency and full 2 phase shift for the wavelength range of 1400-1600 nm. At the central wavelength around 1504 nm, the total transmission efficiency reaches 97.9%, and the desired anomalous transmission efficiency is up to 96.1% with an anomalous refraction angle as large as 30.09°. By adjusting the period and the number of nanorods in one unit cell, the anomalous refraction angle can reach 68.03°, and the anomalous transmission efficiency exceeds 60% within a bandwidth of 50 nm. Theresults are more excellent than those of most present phase-gradient metasurface structures. The superior performance of the proposed structure may pave the way for its application in wavefront control optical devices.
Provenance Identification of the Inkslab Unearthed from Liangfu Gao’s Grave of the Song Dynasty (960-1279 CE) in Chengdu, Sichuan, China
Authors: Wang Tongyang , Gong Yangmin , Wang Shiming , Xiao Lin , Yang Tao 
Published: December 2020

Abstract
In order to infer the provenance of ancient inkslab excavated from Liangfu Gao’s Grave of the Song dynasty (960-1279 CE) in Chengdu, a multi-analytical approach, including polarizing microscope, scanning electron microscope (SEM), X-ray powder diffraction (XRD), energy dispersive spectroscopy (EDS), X-ray fluorescence (XRF), inductively coupled plasma-atomic emission spectrometry (ICP-AES) and inductively coupled plasma mass spectrometry (ICP-MS) was used for the complete characterization of the ancient inkslab and the collected sample materials of this inkslab. The comparison of the results about mineral structure, major, trace and rare earth elements (REE) suggested that this unearthed inkslab of Song dynasty was Pu inkslab, which was famous in Pujiang County of Chengdu, and conjectured that its particular structure made it show the good inking performance. This work provided a reliable basis for the study of the historical and cultural inheritance of the Gao family, providing more direct evidence for the produce and development of the inkslab in the Song Dynasty.
Preoperative Controlling Nutritional Status (CONUT) Score Predicts Short-Term Outcomes of Patients with Gastric Cancer after Laparoscopy-Assisted Radical Gastrectomy
Authors: Qian Yun , Liu Huaying , Pan Junhai , Yu Weihua , Lv Jiemin , Yan Jiafei , Gao Jiaqi , Wang Xianfa , Ge Xiaolong , Zhou Wei 
Published: December 2020

Abstract
Background: As an emerging prediction tool, the Controlling Nutritional Status (CONUT) score has shown good assessment ability of postoperative outcomes in cancer patients. This study assessed the role of the preoperative CONUT score in short-term outcomes of gastric cancer (GC) after laparoscopic gastrectomy.Methods: Three hundred and nine patients undergoing laparoscopic gastrectomy from January 2016 to June 2019 were analyzed, retrospectively. GC patients were divided into two groups according to the optimal cut-off value of the CONUT. The clinical characteristics and postoperative complications were analyzed and evaluated in two groups. The risk factors of complications were identified by univariate and multivariate analysis.Results: 309 patients received laparoscopic gastrectomy, and 91 (29.4%) patients suffered from postoperative complications. The preoperative CONUT score showed a good predictive ability for postoperative complications (area under the curve (AUC)=0.718, Youden index=0.343) compared with other indexes, with an optimal cut-off value of 2.5. Patients with high CONUT score suffered a significantly higher incidence of overall complications (P<0.001). Age, haemoglobin level, C-reactive protein level, red blood cell level, CONUT scores, type of operative procedure, pathological TNM classification of T1, T4, N0, and N3, and pathological stage of I and III were associated with postoperative complications (P<0.05). Furthermore, preoperative CONUT score was identified as an independent risk predictor of postoperative complications (P=0.012; OR=2.433; 95% CI: 1.218-4.862) after multivariate analysis.Conclusions: The preoperative CONUT score is a practical nutritional assessment for predicting short-term outcomes in patients with gastric cancer after laparoscopy-assisted gastrectomy.
Acute Lymphoblastic Leukemia Masquerading as Vogt-koyanagi-harada Disease
Authors: Arce Ana , Relaño Naiara , Artaraz Joseba , Fonollosa Alex 
Published: December 2020

Abstract
Purpose: To report a case of Acute Lymphoblastic Leukemia masquerading as Vogt-Koyanagi-Harada disease.Case Report: A 61-year-old man presented with decreased visual acuity in both eyes. Optical coherence tomography showed bilateral exudative retinal detachment and fluorescein angiography pinpoint leakage. The patient was diagnosed with Vogt-Koyanagi-Harada disease. Blood analysis revealed increased percentage of blast cells (69%) and bone marrow biopsy confirmed the diagnosis of acute B cell lymphoblastic leukemia. He received chemotherapy treatment with multiple drugs including asparaginase, which caused hepatic disease and patient’s death despite ocular findings improvement.Conclusions: Acute lymphoblastic leukemia may present as a bilateral exudative retinal detachment and can mimic VKH. Therefore, clinicians should take into consideration the possibility of leukemia in such patients. This fact stresses out the importance of multidisciplinary management of uveitis conditions.
Improvement of Cost Performance Based on Bim Quantity Take-off Hospital Structure Work
Authors: Husin Albert Eddy , Meisaroh Myrna , Rahmawati Diah Ika , Kussumardianadewi Bernadette Detty 
Published: December 2020

Abstract
Indonesia's population is ranked 4th in the world after India and the United States, as well as the global Covid-19 pandemic, Indonesia is also recorded with the most cases of infections and deaths due to Covid-19 in ASEAN, therefore Hospitals in Indonesia has not been able to represent the need for beds and health services. Therefore, the hospital building construction project has become a driven demand for the fulfillment of health services for the Indonesian population. Estimation is one of the causes of the cost overrun. Implementation of Building Information Modeling Quantity take-off (BIM QTO) in hospital structural work can be done if the cost breakdown is ≤ 24%. Statistical analysis by using the Relative Importance Index (RII) has a result in 10 rankings of factors that influence the implementation of BIM QTO, namely drawing, completeness Bill of Quantity (BoQ), TOR & specifications, cost reduction, preparation of activities in the work breakdown structure, cost breakdown, 3D modeling details, Data Interoperability, Quantity Take Off, Subcont & Supplier pricing, and cost database. Study cases with the implementation of BIM QTO on hospital building structures work cost efficiency up to 6.18%.
Prevalence of Vitamin A Deficiency And Associated Factors Among Children Aged 6-59 Months In Dera District, Northwest Ethiopia: A Cross-Sectional Study
Authors: Hune Yidrsail , Asaye Hirut , Negesse Ayenew , Temesgen Habtamu , Yirga Tadesse , Mekonnen Habtamu 
Published: December 2020

Abstract
Background: Vitamin A is a fat-soluble vitamin essential for the proper functioning of the immune system. It fondes both animal and plant sources in the form of retinol from animal sources or beta-carotene from plant source foods. Due to increased nutrient need and the severity of the potential health consequences are associated with vitamin A deficiency (VAD), preschool children and pregnant women are considered as the most at risk segments of the community. Hence, this study aimed to assess the prevalence of VAD and associated factors among children aged 6-59 months in Dera woreda, Northwest Ethiopia. Methods: Community based quantitative cross-sectional study was conducted among children aged 6-59 months in Dera woreda from December 1/2018 to January 1/2019. Multistage random sampling was used to select the required samples (267). Data were coded and entered into Epi-data version 3.1 and exported to SPSS (Statistical Package for Social Sciences) version 20 for analysis. Binary logistic regression was fitted. Both bivariable and multivariable analyses were used to identify factors associated with VAD. Those variables that were showed significant association in multivariable association at P value less than 0.05 declared as statistically significant factors of VAD among children age 6-59 months. Results: Two hundred sixty seven mother-children Pairs were included in the study making a response rate of 94.7%. The overall prevalence of Vitamin A deficiency among children age 6-59 months was 7.8% (95% CI (4.7, 11.3). Antenatal care follow up (AOR: 0.446,95 % CI (0.155, 0.980)); birth interval within 2 year (AOR: 0.392, 95 % CI (0.107, 0.839)), and age group of24-35 months (AOR; 1.206, 95 % CI (1.037, 6.129)) were significantly associated with vitamin-A deficiency. Conclusion: The overall prevalence of vitamin A deficiency in this study was found to be lower than the national and regional prevalence. According to this study, VAD is a mild public health problem. Age of children, birth interval, ANC follow up, remain the most important associated factors for vitamin A deficiency. Therefore to decrease the prevalence of VAD, ANC service should be strengthened and we should focus on older children birth interval and age- based food needs.
Effect of Dissolved Oxygen and Acid on the Yield of 2,3-butanediol by Saccharomyces Cerevisiae W141
Authors: Yin ZiLiang , Liu DeAn , Ye ZeMing , Ge Jingping 
Published: December 2020

Abstract
Background: The yeast Saccharomyces cerevisiae is a promising host cell to produce 2,3-butanediol (2,3-BDO). However, the fermentation environment restricts 2,3‑BDO yield, productivity, and titre from engineered yeast. In the present study, we propose a strategy in which a suitable dissolved oxygen content and acid stress level can improve the 23-BDO yield of S. cerevisiae W141. Five different concentrations of short-chain fatty acids were evaluated and noxE overexpression was performed to disrupt the intracellular redox balance and alter the NADH content associated with 2,3‑BDO synthesis, which can significantly increase or inhibit 2,3‑BDO yield.Results: The five assayed short-chain fatty acids have different effects on the fermentation characteristics of yeast, were formic, butyric and valeric acids can inhibit the synthesis of 2,3‑BDO. Only low concentrations of acetic and propionic acids could significantly increase the yield of 2,3‑BDO, especially when 1 g/L acetic acid was added, which stimulated the expression of acid stress-related genes in S. cerevisiae W141 (haa1p and hog1p) and increase the 2,3-BDO yield by 29.74%. To further verify that acid stress primarily disrupts the intracellular redox balance by altering the NADH content, we constructed a S. cerevisiae strain, W141-E, which overexpresses the noxE gene of Lactobacillus. After adding 1 g/L acetic acid, the 2,3‑BDO yield from in S. cerevisiae W141-E increased by 43.64%, confirming the validity of our strategy. When the optimized fermentation oxygen content was 0.6 vvm, the 2,3‑BDO yield from S. cerevisiae was greatly improved after the addition of acetic acide.Conclusions: In the present study, we demonstrated that a suitable dissolved oxygen and acid stress are highly effective for increasing the 2,3-BDO yield from S. cerevisiae W141. 2,3-BDO biosynthesis was heavily dependent on the intracellular NADH content, which is closely associated with glycolysis and the TCA cycle and is likely important for the production of 2,3-BDO by S. cerevisiae.
Implementation of Foodcare a Hospital Nutritional Care Concept: A Pilot Study
Authors: Rasmussen Nanna Møller Lykkegaard , Erichsen Alexander , Christensen Allan Stubbe , Frederiksen Kirstine Guld , Okkels Signe Loftager , Viggers Lone 
Published: December 2020

Abstract
Background: Different attempts have been made to improve nutritional care and food intake in hospital inpatients. One way may be to improve the individual customisation of meals and meal time points. This pilot study compared the food concept FoodCare consisting of customised meals served on demand and standardised meals served at fixed time points concerning energy and protein intake in medical inpatients. Method: A pilot study including medical lung inpatients at a Danish regional hospital. The control group received a set menu with limited choices served at fixed times. The intervention group received a menu of customised dishes prepared by food professionals and served on demand. Results: Twelve patients were included in the control group and 26 patients in the intervention group. In the intervention group, the tendency showed an increased energy (8.8 ± 2.7 MJ (mean ± SD) compared with the control group of 7.3 ± 2.0 MJ, p=0.10) and protein intake (74 ± 26 grams compared with the control group of 60 ± 18 (mean ± SD) grams, p=0.08). Conclusion: This pilot study demonstrated that a self-selected menu served on demand may potentially increase energy and protein intake in medical inpatients. The concept should be further tested in a randomised control trial with a sufficient sample size.
Hepatic Lipidomics Reveals the Homeostasis and Profile of Sphingomyelin from Yak Butter in Normal-Fat Diet-Fed Rats
Authors: LUO Xin , SUN Wancheng , LUO Yihao 
Published: December 2020

Abstract
Background: Dietary sphingomyelin was showed to inhibit the uptake of lipids in mice fed with a high-fat diet, however, the effect of sphingomyelin on normal diet was on reported. The current study aims to examine the effects of sphingomyelin extracts from yak butter on hepatic steatosis and inflammation in C57/B6J mice fed with a normal diet. Methods: A UHPLC-QTOF-MS based lipidomics method was utilized to screen the liver metabolites and predict the dominant potential metabolic pathways after sphingomyelin feeding. Results: The results showed that sphingomyelin extracts reduced the accumulation of lipid droplets, suppressed the expression of pro-inflammatory factors IFN -γ, IL-6 and TNF - α, synchronously, promoted the expression of anti-inflammatory factors IL-10, IL-4 and IL-1Ra. In addition, sphingomyelin extracts exhibited the modulation on liver lipid metabolism when supplement sphingomyelin in normal diet for one month and five months. Specifically, 16, 68 different metabolites and 2, 6 metabolic pathways were identified by quantitative lipidomics, respectively. Six CERs including Cer(d18:1/18:0), Cer(d18:1/20:0), Cer(d17:1/22:0), Cer(d17:1/24:1), Cer(d17:1/24:0) and Cer(d17:0/26:1), six SMs including SM(d15:0/24:1), SM(d14:0/26:1), SM(d14:1/24:1), SM(d15:1/22:0), SM(d15:1/24:1) and SM(d19:1/26:1), and PS(18:1/22:6) were identified and can be used as potential biomarkers of steatosis and inflammation.Conclusions: This study highlighted the effects of yak butter sphingomyelin on hepatic steatosis, tissue inflammation and lipid metabolism of mice under a normal diet.
Comparison of citrate anticoagulation strategies in hemodialysis patients at high risk of bleeding: a multicenter prospective observational cohort study
Authors: Chen Shasha , Xu Mingjie , Wang Amanda Y , Liao Jinlan , Xu Wenhua , Jiang Lei , Yang Bin , Xiong Ying , Wang Shaoqing , Zhou Xiaoyan , Li Zan , Zhao Jiawei , Zhang Xuehui , Wang Dongmei , Lin Min , He Jia , Li Yan , He Qiang , Liu Li , Li Guisen , Hong Daqing 
Published: December 2020

Abstract
Background

To explore the effect of different citrate anticoagulation strategies and provide reference for prospective large sample RCT, we collected RCA strategies from different centers systematically and prospectively to compare the effectiveness and safety of different RCA strategies in hemodialysis (HD) patients.
Methods

A prospective observational cohort study was conducted in eight centers in Sichuan, China. RCA strategies were divided into three groups: RCA-one (Prefilter trisodium citrate infusion only); RCA-two (pre and post filter trisodium citrate infusion); RCA + saline (Prefilter trisodium citrate and post filter normal saline infusion). The blood flow ranged from 150–260 ml/min and citrate was infused at a rate of 180–260 mL/h.
Results

Totally 195 patients with 481 sessions of RCA were enrolled, including 141 patients, 337 sessions in the RCA-one group, 51 patients,133 sessions in the RCA-two group and 3 patients, 11 sessions in the RCA + saline group. The proportion of complete scheduled dialysis time was 97, 99.7 and 97.7% (p = 0.037) in three groups respectively, the majority of the adverse events were hypotension (5.5%), muscle cramps (0.8%), and access dysfunction (2.0%), most of which were mild in intensity. Blood coagulation score < 3 in venous expansion chamber were 83.1, 94.6 and 70%, respectively (p < 0.001). Blood coagulation score < 3 in dialyzer were 95.3, 96.1 and 90%, respectively (p = 0.83). Serum calcium levels before the venous line in RCA-two was significantly decreased at 2 h after treatment(p = 0.03). The serious clotting score (= 3) in venous expansion chamber in the RCA-two group was significantly lower than the RCA-one and saline group (p < 0.001). RCA-two had the lowest percentage of adverse events including hypotension (p = 0.023) and muscle cramps (p = 0.001) than other groups.
Conclusion

Citrate anticoagulation is safe and effective in general hemodialysis. Our study shows no significant difference in the circuit survival time among the three administrative strategies of citrates. Administration of citrate to both arterial and venous line appeared to provide better anticoagulation of intravenous jug and had the lowest percentage of adverse events.
Angiography significantly decreased serum levels of IL-8 independent of artery stenosis
Authors: Zare Lida , Eidi Akram , Safarian Mohammad , Arababadi Mohammad Kazemi 
Published: December 2020

Abstract
Background

Angiography is a safe cardiovascular technique for the diagnosis and treatment of the cardiovascular disorders. The potential effects of angiography on the cytokines are yet to be clarified completely. Interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-α) are the important pro-inflammatory cytokines that participate in the pathogenesis of artery stenosis. The aim of his project was to study the angiography effects on the serum levels of IL-8 and TNF-α.
Methods

Fifty-five participants in three groups, without, with one and with more than one artery stenosis, were explored in this project. Serum levels of IL-8 and TNF-α were measured in the participants before and after angiography using enzyme linked immunosorbent assay (ELISA) technique.
Results

Serum levels of IL-8, but not TNF-α, were significantly decreased following angiography. X-ray doses had moderate positive correlation with serum levels of TNF-α in the patients with more than one artery stenosis. Serum levels of IL-8 and TNF-α were not different among male and female participants in all groups.
Discussion

Angiography may be a protective factor for inflammation in IL-8 dependent manner. Using angiography in the patients with more than one artery stenosis needs to be executed cautiously.
Preexisting resistance in cotton bollworm increases the risk of resistance to the concurrently planted Bt cotton and Bt maize
Authors: Wang Wenhui , Xu Feng , Huang Yunxin , Feng Hongqiang , Wan Peng 
Published: December 2020

Abstract
Background

Transgenic maize expressing toxins derived from the bacterium Bacillus thuringiensis (Bt) may be commercially planted in northern China where Bt cotton has been planted for more than two decades. While Bt maize brings additional benefits for insect control, it complicates the resistance management of cotton bollworm (CBW), Helicoverpa armigera (Lepidoptera, Noctuidae), a common target of Bt cotton and Bt maize.
Results

We used a two-locus population genetic model to assess the risk of resistance in CBW when Bt cotton and Bt maize are planted concurrently. Results of model simulations showed that planting Bt maize together with Bt cotton significantly increases the risk of resistance if Bt cotton and Bt maize share a similar Bt toxin. The risk of resistance is higher in the case of one-toxin Bt maize than in the case of two-toxin Bt maize. Parameters associated with the preexisting resistance in CBW all could impact on the risk of resistance but with different extents. Among them, the most notable ones are the dominance of resistance and fitness cost, which can dramatically affect the risk of resistance, especially when the proportion of natural refuges is reduced.
Conclusions

We concluded that the preexisting resistance in CBW to Bt cotton can significantly increase the risk of resistance when Bt maize and Bt cotton are planted concurrently and that using two-toxin Bt cotton and maize instead of one-toxin ones are needed in order to reduce the risk of resistance.