bluuebunny/crossref_metadata_2025_split huggingface dataset:
КОНЦЕПТ ‘ЕДА’ В РАССКАЗЕ НИКОЛАЯ КОНОНОВА «ЕГЭ В ДВА ЭТАПА»
Authors: Unguryanova Elena Alexandrovna 
Published: May 2020

Цель. Настоящая статья посвящена изучению языковой репрезентации художественного концепта ʻЕдаʼ в рассказе Николая Кононова «ЕГЭ в два этапа». Автор ставит целью выявить основные функции авторского концепта ʻЕдаʼ. В соответствии с поставленной целью в работе формируются и решаются следующие задачи: 1. обосновать актуальность концепта ʻЕдаʼ для современных лингвистических исследований; 2. изучить языковую репрезентацию концепта ʻЕдаʼ в тексте рассказа; 3. выявить роль концепта ʻЕдаʼ в формировании смыслового пространства рассказа.Метод или методология проведения работы. Исследование опирается на следующие методы и приемы: сравнительно-сопоставительное описание, структурно-семантический анализ лексических единиц, анализ словарных дефиниций, историко-этимологическое комментирование.Результаты. Исследование выявило, что большая часть сцен в рассказе так или иначе связана с едой, которая играет существенную роль в формировании структуры образа персонажей. Концепт ʻЕдаʼ участвует в формировании концепта ʻТелоʼ, который представлен на эксплицитном уровне. Концепт ʻЕдаʼ формирует основу смыслового пространства текста и участвует в формировании концептуальной оппозиции ʻДуша-Телоʼ.Область применения результатов. Результаты данного исследования могут быть полезны, в частности, при изучении когнитивных особенностей художественных текстов, в интерпретационной лингвистике, при чтении спецкурсов, посвященных современному российскому постмодернизму, а также при разработке лекционных и практических курсов по лингвистике текста.
Formulasi Bakteri Filosfer Padi dan Aplikasinya untuk Mengendalikan Penyakit Hawar Daun Bakteri
Authors: Tridesianti Siska , Akhdiya Alina , Wahyudi Aris Tri 
Published: May 2020

Xanthomonas oryzae pv.oryzae is a casual agent of bacterial leaf blight disease (BLB) of rice. The disease can infect every phases of plant growth and can reduce rice production. In the previous study we have isolated nonpathogenic phyllosphere bacteria against X. oryzae pv.oryzae. For further study, in the present work we developed the formulation of the phyllosphere bacteria and tested their effectiveness against BLB in greenhouse trials. Out of three alternative medium used in culturing bacterial cell biomass, it was revealed that potato broth served as the best medium in comparison with skim milk molasses and bran extract. Formulation of phyllosphere bacteria was conducted by using of talc as main carrier, i.e. approximately 109 cfu g-1of main carrier. Application of the formula on rice leaves indicated that BFV 60, BFF 69, BFR 203 and BFR 153 were the best formula for controlling BLB and were able to reduce disease incidence up to 40.73%, 39.72%, 39.26%, and 28.07%, respectively
A Comparison of Kinetic and Kinematic Variables During the Midthigh Pull and Countermovement Shrug, Across Loads
Authors: Meechan David , Suchomel Timothy J. , McMahon John J. , Comfort Paul 
Published: May 2020

Abstract
Meechan, D, Suchomel, TJ, McMahon, JJ, and Comfort, P. A comparison of kinetic and kinematic variables during the midthigh pull and countermovement shrug, across loads. J Strength Cond Res 34(7): 1830–1841, 2020—This study compared kinetic and kinematic variables during the midthigh pull (MTP) and countermovement shrug (CMS). Eighteen men (age: 29.43 ± 3.95 years, height: 1.77 ± 0.08 m, body mass: 84.65 ± 18.79 kg, and 1 repetition maximum [1RM] power clean: 1.02 ± 0.18 kg·kg−1) performed the MTP and CMS at intensities of 40, 60, 80, 100, 120, and 140% 1RM, in a progressive manner. Peak force (PF), mean force (MF), peak velocity, peak barbell velocity (BV), peak power, (PP), mean power (MP), and net impulse were calculated from force-time data during the propulsion phase. During the CMS, PF and MF were maximized at 140% 1RM and was significantly greater than the MTP at all loads (p ≤ 0.001, Hedges g = 0.66–0.90); p < 0.001, g = 0.74–0.99, respectively). Peak velocity and BV were significantly and meaningfully greater during the CMS compared with the MTP across all loads (p < 0.001, g = 1.83–2.85; p < 0.001, g = 1.73–2.30, respectively). Similarly, there was a significantly and meaningfully greater PP and MP during the CMS, across all loads, compared with the MTP (p < 0.001, g = 1.45–2.22; p < 0.001, g = 1.52–1.92). Impulse during the CMS was also significantly greater across all loads (p < 0.001, g = 1.20–1.66) compared with the MTP. Results of this study demonstrate that the CMS may be a more advantageous exercise to perform to enhance force-time characteristics when compared with the MTP, due to the greater kinetics and kinematic values observed.
The Flywheel Paradigm in Team Sports: A Soccer Approach
Authors: Raya-González Javier , Castillo Daniel , Beato Marco 
Published: May 2020

ABSTRACT
Strength training is a key strategy to improve performance and injury prevention in team sports. Accordingly, several methods have been used, although because of the benefits reported after training based on eccentric contractions, the use of flywheel (FW) devices has extended within the periodization of strength training of team sports. However, nowadays, there is no clear consensus about the parameters used to optimize the training effects. This article examines the research behind these claims and attempts to draw evidence-based conclusions as to the practical implications for a precise use of FW with team-sport players, attending to their specific demands and objectives.
El lenguaje como creador de realidades y opinión pública: análisis crítico a la luz del actual ecosistema mediático
Authors: Civila Sabina , Romero-Rodriguez Luis Miguel , Aguaded Ignacio 
Published: May 2020

Este trabajo analiza cómo los medios de comunicación construyen realidad social mediante el lenguaje. La realidad social es revisada como un constructo discursivo fundamentado en el principio antrópico de la información y en el axioma watzlawickiano de que “es imposible no comunicar”. Se tiene como objetivo principal analizar cómo el concepto de “opinión pública” ha evolucionado con el desarrollo de las Tecnologías de Información y Comunicación (TIC). Para ello, se ha realizado una revisión crítica de la literatura científica, realizando un mapeo por las bases de datos WoS y Scopus, para luego determinar a partir de un estado de la cuestión cómo se forman las nuevas definiciones de opinión pública, entendiendo así el ecosistema mediático y las interacciones de los individuos en el plano de la comunicación digital. Como conclusión principal se destaca que la opinión pública ya no es solo creada unidireccional y monopólicamente a través de los medios de comunicación convencionales, sino también con la interacción y participación de la “audiencia prosumidora” en el seno de las redes sociales. Sin embargo, esto no es indicativo de que se ha perdido por completo el rol de los medios de comunicación en el control social a través de estrategias como el framing (encuadre) y priming (priorización) e incluso han surgido, a partir de esta construcción interactiva de las realidades, nuevos vicios informativos como las fake news (noticias falsas).
A Hélice Quádrupla e sua relação com a visão de futuro dos Parques Científicos e Tecnológicos consolidados no Brasil
Authors: Mineiro Andréa Aparecida da Costa , Castro Cleber Carvalho de 
Published: May 2020

Objetivo: Entender como a sociedade, enquanto representante da HQ, atua em Parques Científicos e Tecnológicos (PCTs) consolidados a partir da percepção de seus gestores. Para tanto, foi adotado o estudo de casos múltiplos em três PCTs brasileiros consolidados.
Metodologia: Foi adotado o estudo de casos múltiplos em três PCTs brasileiros consolidados. Os dados foram coletados por meio de notas de campo, documentos e entrevistas, triangulados e submetidos a análise de conteúdo.
Resultados: Entre os resultados destacam-se as associações, profissionais liberais e coletivos como representantes da sociedade, que foi percebida de forma beneficiária e ativa, o que varia de acordo com o PCT estudado, e há fortes relações da sociedade com as concepções futuras dos PCTs.
Implicações práticas e sociais: Os PCTs tem evoluído sua função para além de um espaço de geração de emprego e renda, o futuro dos PCTs tem sido abordado como um espaço difuso na cidade e que atua extramuros, impactando diretamente a sociedade. Essa conexão com a sociedade remonta ao modelo de Hélice Quádrupla (HQ), que apresenta carências teóricas em sua representação e operacionalização, principalmente em ambientes de inovação.
Originalidade: Esse artigo contribui por elucidar as representações da sociedade e sua caracterização, trazendo a diferenciação em ambientes periféricos, além de contribuir na descrição das formas de conexão da sociedade e no apontamento de diferentes caminhos que são perseguidos para aumentar a aproximação dos PCTs à sociedade.
Preclinical Study of the Pharmacokinetics of p75ECD-Fc, a Novel Human Recombinant Protein for Treatment of Alzheimer’s Disease, in Sprague Dawley Rats
Authors: Kelliny Sally , Lam Ho Yin , Parikh Ankit , Wang Yan-Jiang , Bobrovskaya Larisa , Upton Richard , Zhou Xin-Fu 
Published: May 2020

Background:
p75ECD-Fc is a recombinant human protein that has recently been developed as a novel
therapy for Alzheimer’s disease. Current studies showed that it is able to alleviate Alzheimer’s disease pathologies in
animal models of dementia. Thus, knowledge about the pharmacokinetic behavior and tissue distribution of this
novel protein is crucial in order to better understand its pharmacodynamics and more importantly for its clinical
development.

Methods:
The aim of this study is to characterize the pharmacokinetics of p75ECD-Fc after single intravenous and
subcutaneous injection of 3mg/kg in Sprague Dawley rats. We calculated the bioavailability of the SC route and
studied the distribution of that protein in different tissues, cerebrospinal fluid and urine using ELISA and immunofluorescence
techniques. In-vitro stability of the drug was also assessed. Data obtained were analyzed with
Non-compartmental pharmacokinetic method using R.

Results:
Results showed that the bioavailability of SC route was 66.15%. Half-life time was 7.5 ± 1.7 and 6.2 ± 2.4
days for IV and SC injection, respectively. Tissue distribution of p75ECD-Fc was modest with the ability to penetrate
the blood brain barrier. It showed high in vitro stability in human plasma.

Conclusion:
These acceptable pharmacokinetic properties of p75ECD-Fc present it as a potential candidate for clinical
development for the treatment of Alzheimer’s disease.
A Computational Approach to Investigate the HDAC6 and HDAC10 Binding Propensity of Psidium guajava-derived Compounds as Potential Anticancer Agents
Authors: Adewole Kayode Ezekiel , Ishola Ahmed Adebayo 
Published: May 2020

Background:Different parts of Psidium guajava are consumed as food and used for medicinal purposes around the world. Although studies have reported their antiproliferative effects via different biochemical mechanisms, their modulatory effects on epigenetic modification of DNA molecules via histone deacetylases (HDACs) are largely unknown.Objective:This study was carried out to investigate the histone deacetylase 6 (HDAC6) and histone deacetylase 10 (HDAC10) binding propensity of guava-derived compounds, using in silico methods, in other to identify compounds with HDAC inhibitory potentials.Methods:Fifty-nine guava-derived compounds and apicidin, a standard HDAC inhibitor, were docked with HDAC6 and HDAC10 using AutodockVina after modeling (SWISS-MODEL server) and validating (ERRAT and VERIFY-3D) the structure of HDAC10. Molecular interactions between the ligands and the HDACs were viewed with Discovery Studio Visualizer. Prediction of binding sites, surface structural pockets, active sites, area, shape and volume of every pocket and internal cavities of proteins was done using Computed Atlas of Surface Topography of proteins (CASTp) server, while absorption, distribution, metabolism, and excretion (ADME) study of notable compounds was done using Swiss online ADME web tool.Results:2α-hydroxyursolic acid, asiatic acid, betulinic acid, crategolic acid, guajadial A and B, guavacoumaric acid, guavanoic acid, ilelatifol D, isoneriucoumaric acid, jacoumaric acid, oleanolic acid, psiguadial A, B, and C demonstrated maximum interaction with the selected HDACs. ADME studies revealed that although isoneriucoumaric and jacoumaric acid ranked very high as HDAC inhibitors, they both violated the Lipinski’s rule of 5.Conclusion:This study identified 13 drugable guava-derived compounds that can be enlisted for further studies as potential HDAC6 and HDAC10 inhibitors.
Research Progress in Flavonoids as Potential Anticancer Drug Including Synergy with Other Approaches
Authors: Hussain Yusuf , Luqman Suaib , Meena Abha 
Published: May 2020

Background:In chemotherapy for cancer, conventional drugs aim to target the rapidly growing and dividing cells at the early stages. However, at an advanced stage, cancer cells become less susceptible because of the multidrug resistance and the recruitment of alternative salvage pathways for their survival. Besides, owing to target non-selectivity, healthy proliferating cells also become vulnerable to the damage. The combination therapies offered using flavonoids to cure cancer not only exert an additive effect against cancer cells by targetting supplementary cell carnage pathways but also hampers the drug resistance mechanisms. Thus, the review aims to discuss the potential and pharmacokinetic limitations of flavonoids in cancer treatment. Further successful synergistic studies reported using flavonoids to treat cancer has been described along with potential drug delivery systems.Methods:A literature search was done by exploring various online databases like Pubmed, Scopus, and Google Scholar with the specific keywords like “Anticancer drugs”, “flavonoids”, “oncology research”, and “pharmacokinetics”.Results:Dietary phytochemicals, mainly flavonoids, hinder cell signalling responsible for multidrug resistance and cancer progression, primarily targeting cancer cells sparing normal cells. Such properties establish flavonoids as a potential candidate for synergistic therapy. However, due to low absorption and high metabolism rates, the bioavailability of flavonoids becomes a challenge. Such challenges may be overcome using novel approaches like derivatization, and single or co-delivery nano-complexes of flavonoids with conventional drugs. These new approaches may improve the pharmacokinetic and pharmacodynamic of flavonoids.Conclusion:This review highlights the application of flavonoids as a potential anticancer phytochemical class in combination with known anti-cancer drugs/nanoparticles. It also discusses flavonoid’s pharmacokinetics and pharmacodynamics issues and ways to overcome such issues. Moreover, it covers successful methodologies employed to establish flavonoids as a safe and effective phytochemical class for cancer treatment.
Spectroscopic Determination of Dissociation Constants of Some 4- nitrobenzaldehyde-4-substituted phenyl-1-carbonylhydrazones in Sodium Hydroxide Media
Authors: Jankulovska Mirjana S. , Spirevska Ilinka , Dimova Vesna , Jankulovska Milena 
Published: May 2020

Purpose:
Hydrazones are a class of azomethines with a wide spectrum of pharmacological properties which are influenced by pH
of the media. The purpose of this study was investigation of acid-base properties of five 4-nitrobenzaldehyde-4-substitutedphenyl1-carbonylhydrazones in sodium hydroxide media (14>pH>7).

Method:
The dissociation process was followed by UV-Vis spectroscopy, in the ethanol-water (V/V, 1:1) solutions, at room
temperature. Semiempirical methods AM1 and PM3 were applied for determination of the deprotonation enthalpies.

Results:
The changes in the UV-Vis spectra, as well as the deprotonation enthalpies, suggested that the
dissociation process for four investigated hydrazones with an amide group took place in one step. The
exception with two dissociation steps was hydrazone with amide and hydroxyl group. The pH region of
dissociation was from pH 10.8 to pH 11.6 for the first step and between pH 11.7 and pH 12.1 for the
second step of dissociation. The influence of the ethanol on the UV-Vis spectra was eliminated by the
method of Characteristic Vector Analyses (CVA). The stoichiometric dissociation constants were determined
numerically (pKHA = n·pH + logI) and graphically (intercept of the dependence of logI on
pH) from the absorbance data using experimental and reconstructed UV-Vis spectra, at three different
ionic strengths. Thermodynamic dissociation constants were estimated graphically as an intercept of
dependence of dissociation constant on the square root of the ionic strength.

Conclusion:
The obtained results demonstrated that the influence of the substituents on pKHA values
was not significant, except for hydrazone with amide and hydroxyl group. Namely, the dissociation of
the amide group of this hydrazone was retarded due to the influence of the phenolic group.
CircRNAs and Axes Involved in Thyroid Cancer based on PTC: A
Biomarker for Prognosis, Diagnosis and Treatment
Authors: Shojaeian Ali , Mehri-Ghahfarrokhi Ameneh , Safaei Mohsen 
Published: May 2020

Background:
The circular RNAs (circRNAs) are defined as single-stranded RNA
molecules with a length of 100 bp up to 4 kb, resulting from head-to-tail junctions at splice sites
of spliced transcripts. Moreover, they are stable and abundant conserved RNA molecules, which
often have tissue-specific expression and developmental stages. Dysregulation of circRNAs has
been identified in many types of malignancies that mainly affect the progression of human
cancers.

Methods:
This review was prepared via searching of the databases of Science Direct, Directory
of Open Access Journals (DOAJ), Google Scholar, Pub-Med (NLM), Scopus, Web of Science,
and hand searching using relative keywords. The selected papers were fully reviewed and
required information for the review was extracted and summarized.

Results:
Previous studies indicated that BRAF-activated non-protein coding RNA (BANCR) expression
had been increased in thyroid tumors compared with adjacent normal tissues.
Additionally, BANCR had mediated epithelial-mesenchymal transition (EMT) through regulating
the expression of epithelial (E)-cadherin, vimentin, and neuronal (N)-cadherin. Moreover, H19
was an example of a lncRNA that could function either as a tumor promoter or suppressor. An
important part of this study was dedicated to reviewing signaling pathways involved in TC including
extracellular-signal-regulated kinase (ERK) pathway and mitogen-activated protein kinase
(ERK/MAPK), transforming growth factor-β/ (TGF-ß)/Smads, the Janus kinase/signal transducers
and activators of transcription (JAK/STAT), P53, as well as other pathways.

:
Additionally, BANCR had mediated epithelial-mesenchymal transition (EMT) through regulating
the expression of epithelial (E)-cadherin, vimentin, and neuronal (N)-cadherin. Moreover, H19
was an example of a lncRNA that could function either as a tumor promoter or suppressor. An
important part of this study was dedicated to reviewing signaling pathways involved in TC including
extracellular-signal-regulated kinase (ERK) pathway and mitogen-activated protein kinase
(ERK/MAPK), transforming growth factor-β/ (TGF-ß)/Smads, the Janus kinase/signal transducers
and activators of transcription (JAK/STAT), P53, as well as other pathways.

Conclusion:
Briefly, this study provided an overview of the current understanding of the function
of lncRNA and micro RNAs (miRNAs) along with their interactions in TC.
Preparation and Preliminary Evaluation of 68 Ga-Acridine: An Attempt to Study the Potential of Radiolabeled DNA Intercalator as a PET Radiotracer for Tumor Imaging
Authors: Ghosh Subhajit , Das Tapas , Suman Shishu K. , Sarma Haladhar D. , Dash Ashutosh 
Published: May 2020

Introduction:
Acridine is a well-known DNA intercalator and thereby gets easily inserted within
DNA. As uncontrolled rapid cell division is one of the primary characteristics of the tumors, it is expected that
acridine or its suitable derivatives will have preferential accumulation in the tumorous lesions. Therefore, an
attempt was made to radiolabel an acridine derivative with 68Ga and study the potential of the 68Ga-acridine
complex as a PET agent for tumor imaging.

Methods:
9-aminoacridine was coupled with p-NCS-benzyl-DOTA to render it suitable for labeling with 68Ga.
The purified acridine-DOTA conjugate was radiolabeled with 68Ga, eluted from a 68Ge/68Ga radionuclide generator.
Various radiolabeling parameters were optimized and the stability of the radiolabeled preparation was
studied. The biological behavior of the 68Ga-acridine complex was studied both in vitro and in vivo using Raji
cell line and fibrosarcoma tumor bearing Swiss mice, respectively.

Results:
68Ga-acridine complex was obtained with ~100% radiochemical purity under the optimized reaction
conditions involving incubation of 2mg/mL of ligand at 100°C for 30 minutes. The complex maintained a radiochemical
purity of >95% in normal saline and >65% in human blood serum at 3h post-incubation. In vitro cellular
study showed (3.2±0.1)% uptake of the radiotracer in the Raji cells. Biodistribution study revealed significant
tumor accumulation [(11.41±0.41)% injected activity in per gram] of the radiotracer within 1h postadministration
along with uptake in other non-target organs such as, blood, liver, GIT kidney etc.

Conclusion:
The present study indicates the potential of 68Ga-acridine as a PET agent for imaging of tumorous
lesions. However, further detailed evaluation of the agent is warranted to explore its actual potential.
Pressure Control of HVAC System for Corona Virus
Authors: Chung Samuel W. , Jo Jeong Je 
Published: May 2020

Corona Virus is deadly spread out to thousands of healthy people and so strong as to infect to the surrounding people after people. We must keep the deadly virus indoor as much as we can. How? We must not allow the indoor air already contaminated to leak out to the atmosphere, which will transmit to other people. The new virus is so strong and so fast to transmit, it will spread within a few seconds to thousands of people and became patients immediately. To solve the problem, we must build a pressure vessel to keep the virus inside the vessel and not to leak outside. It should be a negative pressure compare to the atmospheric pressure. Another words, is to keep the indoor pressure lower than atmospheric pressure, so the contaminated indoor pressure is lower than outdoor pressure. It is a part of a traditional HVAC operation. This article shows step by step procedures of HVAC system design procedures, with emphasis of the air duct system design. Care must be taken to keep close attention to the maintenance of the system.