bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive aggregate-flow metamodel of the process automatic spacecraft flight control
Authors: Kovtun Vladimir S. 
Published: December 2020

Currently, there is an urgent scientific problem of ensuring the effective implementation of the automatic spacecraft (AS) flight program, taking into account the material, energy and information resource limitations of onboard systems (OS). The consumption of OS resources largely depends on the synergistic phenomena that occur during intersystem interaction in the AS. By using these phenomena, it is possible to increase the efficiency of the use of existing resources, as well as to supplement them with new "synergistic" resources [1,2]. At the same time, synergistic phenomena can lead to premature development of the OS resource and unforeseen (non-calculated) failures and accidents [3]. For purposeful search and use of these synergistic phenomena, it is necessary to conduct a special study of the processes occurring on board. Research becomes possible only when moving from the system-cybernetic model of AS as a " black box "to a system-cybernetic model that provides" transparency "of AS as a" white box", which requires high accuracy and complexity of analysis of processes occurring on board [4]. This situation determines the urgency of developing new engineering techniques and modeling technologies. To create them, it is necessary to solve the problem of the initial stage of building models that describe in one form or another the engineering knowledge of OS development experts and flight control specialists [5]. The development of a universal method for solving the problem of the initial stage of modeling is significantly complicated due to the wide variety of OS, each of which has its own emergent and synergistic properties, which largely depend on the "non-clonability" of their elements [6,7].
In order to simplify the modeling of real OS functioning processes, taking into account their specifics, it is proposed to carry out preliminary development of a formalized cognitively structured aggregate-flow metamodel ("model of models") of the AS flight control process, which contains information about potentially existing capabilities for controlling the state of vehicles in various conditions of implementation of nominal and abnormal processes. Creating a conceptual metamodel allows you to make the transition from the subject formalized model to the next stages of modeling-formal-mathematical and material-functional modeling, which take into account the individual characteristics of the processes on board the AS when controlling its flight. At the same time, the problems of overcoming the complexity of the metamodel, including its dimension, are solved.
Memory Load Alters Perception-Related Neural Oscillations during Multisensory Integration
Authors: Michail Georgios , Senkowski Daniel , Niedeggen Michael , Keil Julian 
Published: December 2020

Integrating information across different senses is a central feature of human perception. Previous research suggests that multisensory integration is shaped by a context-dependent and largely adaptive interplay between stimulus-driven bottom-up and top-down endogenous influences. One critical question concerns the extent to which this interplay is sensitive to the amount of available cognitive resources. In the present study, we investigated the influence of limited cognitive resources on audiovisual integration by measuring high-density electroencephalography (EEG) in healthy participants performing the sound-induced flash illusion (SIFI) and a verbaln-back task (0-back, low load and 2-back, high load) in a dual-task design. In the SIFI, the integration of a flash with two rapid beeps can induce the illusory perception of two flashes. We found that high compared with low load increased illusion susceptibility and modulated neural oscillations underlying illusion-related crossmodal interactions. Illusion perception under high load was associated with reduced early β power (18–26 Hz, ∼70 ms) in auditory and motor areas, presumably reflecting an early mismatch signal and subsequent top-down influences including increased frontal θ power (7–9 Hz, ∼120 ms) in mid-anterior cingulate cortex (ACC) and a later β power suppression (13–22 Hz, ∼350 ms) in prefrontal and auditory cortex. Our study demonstrates that integrative crossmodal interactions underlying the SIFI are sensitive to the amount of available cognitive resources and that multisensory integration engages top-down θ and β oscillations when cognitive resources are scarce.SIGNIFICANCE STATEMENTThe integration of information across multiple senses, a remarkable ability of our perceptual system, is influenced by multiple context-related factors, the role of which is highly debated. It is, for instance, poorly understood how available cognitive resources influence crossmodal interactions during multisensory integration. We addressed this question using the sound-induced flash illusion (SIFI), a phenomenon in which the integration of two rapid beeps together with a flash induces the illusion of a second flash. Replicating our previous work, we demonstrate that depletion of cognitive resources through a working memory (WM) task increases the perception of the illusion. With respect to the underlying neural processes, we show that when available resources are limited, multisensory integration engages top-down θ and β oscillations.
“Boundlessly Different”
Authors: Steinbrecher Bernhard , Achhorner Bernhard 
Published: December 2020

Brass music has become increasingly popular in recent years in Europe’s German-speaking regions, especially among young people, who attend brass festivals, such as Woodstock der Blasmusik, in great numbers.
This article examines this phenomenon within the context of its historical weight. Particularly in Austria, brass music is intertwined strongly with local cultural activity and heritage, alpine folklore, and national identity, with the Habsburg Monarchy and the Nazi era as well as with the rise of Volkstümliche Music and Austrian popular music. The study pinpoints the initial spark of the current popularity to the early 1990s, when young brass musicians set new tones musically and culturally. It illustrates how bands such as Mnozil Brass and Innsbrucker Böhmische, and later Viera Blech and LaBrassBanda, renegotiated established conceptions, ideas, and attitudes, and how they have, or have not, overcome habitualized ways of performing and enjoying brass music.
On a broader level, the article uncovers how narratives related to regionality, Heimat, community, institutionalization, virtuosity, internationality, openness, corporality, and hedonistic pleasure all come together, at times in contradictory ways, in the media and musicians’ ethical-aesthetic discussion about contemporary brass music. Ultimately, a close music-analytical reading of selected songs shows how the music fosters and reflects these interrelations.
Terra Sigillata-Funde in Der Einheimischen Siedlung Lágymányos
Authors: Gabler Dénes 
Published: December 2020

Samian ware of Lágymányos. 65 pieces of Samian ware were unearthed during the excavation of the Eraviscus settlement of Lágymányos. It is a fairly small amount compared to the number of PGW finds, which is well over a thousand pieces. Despite all this, imported ceramic finds unearthed in these sites allow us to set up a timeframe of the lifespan of the settlement. A third of the finds originate from Italia, accordingly, it is presumable that in the middle to the second half of the first century this settlement was already a part of the Roman commercial circuit. Three potteries of Italian origin classifiable into three groups includes a relatively great amount of good quality A2 ware.The 26 pieces include early-type Drag. 29 and early forms also appear amongst the undecorated vessels. There are fewer Central Gaulish finds and even less (3 pieces) of Rheinzabern products. According to the Samian wares found the life of the settlement can be traced up until the Marcomannic wars (166–180 AD).Later finds suggest that the settlement was abandoned or sparsely populated afterward.
Addressing taxonomic challenges for Internet Use Disorders in light of changing technologies and diagnostic classifications. •
Authors: Rumpf Hans-Jürgen , Browne Dillon , Brandt Dominique , Rehbein Florian 
Published: December 2020

AbstractDrawing a distinction between mobile and non-mobile Internet Use Disorders is an important step to clarify blurred current concepts in the field of behavioral addictions. Similarly, future technological advances related to virtual or augmented reality, artificial intelligence or the Internet of things might lead to further modifications or new taxonomies. Moreover, diagnostic specifiers like offline/online might change with technological advances and trends of use. An important taxonomical approach might be to look for common structural characteristics of games and applications that will be amenable to new technical developments. Diagnostic and taxonomical approaches based on empirical evidence are important goals in the study of behavioral addictions.
Дослідження ефективності функціонування АСОЗ ПТЛ прийому зерна з залізничного транспорту на елеваторі «МКХП Орексім» м. Миколаїв
Authors: Кір’язов І.М. , Шестопалов С.В. , Степанов М.Т. , Хобін В.А. 
Published: December 2020

У статті розглядаються результати функціонування в виробничих умовах автоматизованої системи оптимізації завантаження (АСОЗ) поточно транспортних ліній (ПТЛ) прийому зерна з залізничного транспорту на елеваторі «МКХП Орексім» у місті Миколаїв. Система призначена для формування потоку зерна одночасно з декількох вагонів розташованих на різних коліях та стабілізації продуктивності загального потоку зерна на заданому рівні, підвищення продуктивності та виведення її на максимально досяжну з урахуванням паспортних характеристик обладнання ПТЛ, зниження енерговитрат на перевантаження, запобігання аварійних ситуацій, пов'язаних з завалами зерна в башмаках норій. АСОЗ реалізує технології Leffol & Senumac які запатентовані SE Group International. Програмне забезпечення системи інтегровано в програмне забезпечення автоматизованої системи керування технологічними процесами елеватора і дозволяє оператору задавати компоненти потоку прийнятого зерна та початкову продуктивність ПТЛ, здійснювати вибір режиму керування завантаженням ПТЛ та вибір режиму завдання продуктивності ПТЛ в поточній технологічної ситуації, контролювати функціонування АСОЗ. Результати порівняльного аналізу ефективності управління завантаженням при прийомі зерна з залізничних вагонів оператором «вручну» і з використанням автоматизованої системи оптимізації завантаження, проведені в 2020 році, показали наступне: - середній час прийому зерна з залізничних вагонів з урахуванням простоїв зменшилось на 15%; - середня продуктивність прийому зерна без урахування простоїв збільшилася на 10%. При цьому аварійних зупинок транспортного обладнання ПТЛ пов'язаних з завалами зерна на протязі виробничих випробувань та опитної експлуатації не виникало.
Приклади аналізу сталих процесів в системі автоматичного регулювання засобами MATLAB
Authors: Левінський В.М. , Левінський М.В. 
Published: December 2020

Актуальність. Ідентифікація каналу контрольованих збурень залишається актуальною задачею при побудові САР, які забезпечують високу динамічну точність стабілізації регульованої змінної. Ця задача потребує крім знань з теорії випадкових процесів також і навиків застосування сучасних пакетів програм MATLAB, що забезпечують аналіз і синтез систем керування. Мета. Навести приклади застосування пакетів Signal Processing Toolbox та System Identification Toolbox в учбовій задачі ідентифікації динамічних властивостей каналу контрольованих збурень тестового об’єкту керування та виявити вплив на точність визначення параметрів моделі діапазону їх змін, а також інтенсивності та спектрального складу неконтрольованих збурень. Метод. В якості методу дослідження обрано моделювання тестового об’єкту керування в середовищі Simulink. Результати. Наведено експериментальні дані, які характеризують вплив на точність ідентифікації параметрів тестового об’єкту керування зміни його часу запізнення, а також спектрального складу неконтрольованих збурень. Висновки. При відсутності неконтрольованих збурень зміна часу запізнення тестового об’єкту керування не суттєво впливає на точність ідентифікації параметрів його моделі. Ця точність в більшій мірі залежить від інтенсивності неконтрольованих збурень, ніж від їх спектрального складу. В цілому пакети програм Signal Processing Toolbox та System Identification Toolbox можуть бути рекомендовані для підготовки спеціалістів з автоматизації виробничих процесів в отриманні навичок з аналізу сталих процесів в САР.
Uzamış COVID: Yeni bir tanım
Authors: ERBAY Ayşe 
Published: December 2020

Özet
Uzamış COVID’ COVID-19'dan iyileşmiş, ancak hala enfeksiyonun kalıcı etkilerini bildiren ya da beklenenden çok daha uzun süredir olağan semptomları olan kişilerde hastalığı tanımlamak için kullanılan bir terimdir ve semptomların bir aydan daha uzun süre devam etmesi olarak tanımlanmaktadır.COVID-19 tanısı konulan hastaların %10 ila %20’sinde bir aydan daha uzun süren semptomlar görülmekte iken, hastaların %2.3’ünde semptomların 12 haftadan daha uzun sürdüğü gözlenmiştir. Semptomlar yorgunluk, baş ağrısı, dispne, kognitif bozukluk, depresyon, deri döküntüleri ve gastrointestinal şikayetleri içerir.

Summary
Long COVID is a term used to describe the disease in people who have recovered from COVID-19 but still report persistent effects of the infection or have usual symptoms for much longer than expected, and is defined as the persistence of symptoms for more than a month. Symptoms lasting longer than one month were observed in 10% to 20% of patients, while it was observed that symptoms last longer than 12 weeks in 2.3% of patients. Symptoms include fatigue, headache, dyspnoea, cognitive impairment, depression, skin rashes and gastrointestinal complaints.
Metabolic fitness of Candida albicans is indispensable for functional drug efflux, ergosterol, and chitin biosynthesis
Authors: Hans Sandeep , Fatima Zeeshan , Hameed Saif 
Published: December 2020

Background and Purpose: The increment in fungal infections, particularly due to Candida species, is alarming due to the emergence of multidrug resistance (MDR). Hence, the identification of novel drug targets to circumvent the problem of MDR requires immediate attention. The metabolic pathway, such as glyoxylate cycle (GC), which utilizes key enzymes (isocitrate lyase [ICL] and malate synthase [MLS]), enables C. albicans to adapt under glucose-deficient conditions. This study uncovers the effect of GC disruption on the major MDR mechanisms of C. albicans as a human pathogenic fungus.
Materials and Methods: For the purpose of the study, efflux pump activity was assessed by phenotypic susceptibilities in the presence of substrates rhodamine 6G (R6G) and Nile red, along with R6G extracellular concentration (527 nm). In addition, ergosterol content was estimated by the alcoholic potassium hydroxide hydrolysis method. The estimation of chitin was also accomplished by the absorbance (520 nm) of glucosamine released by acid hydrolysis.
Results: The results revealed that the disruption of ICL enzyme gene (Δicl1) led to the impairment of the efflux activity of multidrug transporters belonging to the ATP-binding cassette superfamily. It was further shown that Δicl1 mutant exhibited diminished ergosterol and chitin contents. In addition, all abrogated phenotypes could be rescued in the reverting strain of Δicl1 mutant.
Conclusion: Based on the findings, the disruption of GC affected efflux activity and the synthesis of ergosterol and chitin. The present study for the first time revealed that metabolic fitness was associated with functional drug efflux, ergosterol and chitin biosynthesis and validated GC as an antifungal target. However, further studies are needed to comprehend and exploit this therapeutic opportunity.
Physiological Status of Stunned and Non-Stunned Broilers: Blood Profile, and Brain Histopathology
Authors: Satyaningtijas Aryani Sismin , Ulupi Niken , Sani Yulvian , Santoso Koekoeh , Retnani Elok Budi , Maheshwari Hera , Hanadhita Desrayni , Naldi Jefri , Oktoni Irwan , Anwar David , Saleema Ainul Khadija 
Published: December 2020

Stunning method before slaughtering is considered more animal welfare compared to a non-stunning method and also reduces stress levels in broilers. As for the bleed-out efficiency, testing was done indirectly by blood volume measurement which consists of erythrocyte count, leucocyte count, hemoglobin levels, hematocrit values, and erythrocyte index in broilers. Brain histopathology was also carried out to see the effect of electrical stunning towards the brain tissues. The stunning method used is electrical stunning via water bath with the capacity of 146 mAh. The results showed that the stunning method before slaughtering caused smaller number of erythrocytes and hematocrit values, and the brain histopathology showed that stunning causes encephalopathy.
Lung Change Pattern On Domestic Cat (Felis Silvestris Catus) Exposed By Factory Air Pollution With X-Ray Thorax Interpretation
Authors: Widyawati Ratna , Apritya Desty , Wika Adi Pratama Junianto , Fahmi Asnizar 
Published: December 2020

The pathology density changes for X-Ray interpretation of the lungs are difficult to distinguish, because the disease is not easily classified and may represent a variety of lung disorders. The study was aimed of this research to found the lung disease of domestic cats (Felis Silvestris Catus) that exposure to air pollutions in the industrial area of region Manyar, district Gresik. The type of this research was observational study Explorative that using the simple random sampling and observed nine cats for the sampling.The results of X-ray Thorax in this research showed that there are changing in the 3rd, 4th, 5th, 6th, 7th, an 9th of the sampling cats. On the third, fifth and the seventh of the cats, we found the same condition that there was change the vascular patterns that were enlargement, vascular constriction or ambiguity structures. From the results of the vascular patern indicate the disorder of left-sided heart failure (Mitral Isufisiency) or obstruction of the left atrium. On the fourth of the cat, there was bronchial pattern that showed the classification, dilatation and thickness of the lung. On the sixth of the cats, there were changes on interstitial pattern with the pictures of nodulars that were not structures and on the ninth of the cats, we can found the same conditions with the fourth and the sixth of cats were visible Interstitial Pattern and Bronchial Interstitial Pattern.
The Effectiveness of Triple Fixed-Dose Combination Therapy in the Management of Uncontrolled Arterial Hypertension
Authors: Masharipov Shukhrat , Ataniyazov Khurshid , Shukurova Dilafruz , Khamidullaeva Gulnoz , Abdullaeva Guzal , Kurbanov Ravshanbek 
Published: December 2020

The aim of our study was to identify patients with uncontrolled hypertension (UCH) who were resistant to previous antihypertensive therapy (AHT) and to assess the clinical efficacy of the fixed-dose triple combination (FDTC) therapy during 6 months.	Methods and Results: The study included 156 patients with UCH. The mean age of patients was 57.81±10.8 years; the average duration of AH was 8.87±5.34 years. According to the questionnaire data, all patients received dual or triple free-combination AHT, but did not reach the target blood pressure (BP) level. After the screening stage, all patients were discontinued from previous therapy and assigned to the FDTC therapy. Patients initially taking angiotensin-converting enzyme inhibitors (n=96/61.5%) were switched to single-pill triple combination (SPTC) of perindopril, indapamide and amlodipine (Per/Ind/Aml [5mg/1.25mg/5mg]). Patients initially taking angiotensin receptor blockers (n=60/38.5%) were switched to SPTC of telmisartan, hydrochlorothiazide and amlodipine (Tel/HCTZ/Aml [40mg/12.5mg/5mg]). The primary target level for SBP and DBP was <140mmHg and <90mmHg, respectively. With good tolerability of therapy, we aimed for the recommended target level of SBP/DBP (<130mmHg/<80 mmHg).	All patients underwent the following examinations: assessment of traditional risk factors, physical examination, clinical and biochemical laboratory methods, 12-lead ECG, echocardiography, pulse contour analysis, and 24-hour ambulatory blood pressure monitoring.	The results of our study showed that the FDTC therapy at the indicated initial doses in patients with UCT made it possible to achieve the primary target BP level in 73.7% of patients after 3 months of treatment. A further increase in SPTC doses made it possible to increase the number of patients (after 6 months of treatment)who achieved the primary goal to 92.3%, and the recommended goal in 82.4% of patients.	After 6 months of treatment, against the background of selected doses of SPTC, 7.7% of patients were diagnosed with treatment-resistant hypertension. Conclusion: Markers of UCH are high SBP, DBP, and increased pulse wave velocity, which requires the maximum doses of a full-dose SPTC of antihypertensive drugs (Per/Ind/Aml or Tel/HCTZ/Aml), without wasting time on titration of drug doses.
The structure of Haplotypes and Diplotypes in the PNPLA3 gene in the Yakut Population
Authors: Kurtanov Khariton , Pavlova Nadezhda , Diakonova Aleksandra , Sydykova Lyubovy , Aleksandrova Tuyara , Borisova Yigulana , Dodokhov Vladimir 
Published: December 2020

Background: The first GWAS searching for such genetic factors identified the PNPLA3 gene as a major genetic determinant for the predisposition to nonalcoholic fatty liver disease in Hispanic, African American, and European American populations, according to liver fat contents, a finding that was subsequently confirmed by liver biopsy in Europeans and Asians. The aim of our research was to study the distribution of alleles, genotypes, haplotypes and diplotypes of polymorphic variants of the PNPLA3 gene (rs2294918 and rs738409) in Yakuts.	Methods and Results: The PNPLA3 SNPs (rs2294918 and rs738409) were analyzed by PCR-RFLP reaction. The PNPLA3 rs738409 SNP in the Yakut population is characterized by a high frequency of the risk G allele (72%). According to the PNPLA3 rs2294918 SNP, which suppresses the negative effect of rs738409, the protective PNPLA3 (rs2294918) A allele was found only in 10.7% of study subjects. Analysis of the distribution of the frequency of genotypes in the studied sample of Yakuts showed the predominance of the carriage of the PNPLA3 rs738409 GG genotype (57.3%) and the PNPLA3 rs2294918 GG genotype (80.7%). The frequency of the PNPLA3 (rs2294918) AA and AG genotypes was 2.0% and 17.3%, respectively. The Yakuts often have two diplotypes [GG]-[GG] and [CG]-[GG]. Both diplotypes carry the PNPLA3 rs738409 G allele (45.3% and 28%) and do not carry the PNPLA3 rs2294918 A allele. The high frequency of the [GG]-[GG] and [CG]-[GG] diplotypes in Yakuts (45.3% and 25%, respectively), carrying mutant alleles G (rs738409) and not carrying the A allele (rs2294918), indicates that these diplotypes were probably adaptively favorable to the Yakuts.	Conclusion: The analysis of haplotypes and diplotypes based on the markers rs738409 and rs2294918 of the PNPLA3 gene may contribute to future new biomarkers for the diagnosis of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis, as well as provide fundamental knowledge on human adaptation to cold.