bluuebunny/crossref_metadata_2025_split huggingface dataset:
Driving factors for the success of the green industrial estate: a case study of Pasuruan Industrial Estate Rembang
Authors: Nainggolan H , Wardhani N W S , Leksono A S , Santoso I 
Published: May 2020

AbstractThe concept of green industry became a hot issue all over the world as a result of scarcity of resources and environmental quality degradation. Several developed and developing countries have obligated the implementation of the green industry. Indonesian government through the Ministry of Industry also strives to implement green industry principles by adding green industrial standards through law number 3/2014. Pasuruan Industrial Estate Rembang (PIER) is one of the developing industrial estates in East Java, Indonesia. This paper aims to map out the key factors of environment management that make up a green industrial estate (GIE) in PIER. Data was collected by questionnaire, interview, observation, and documentation. The interview was done with experts from PIER management and several industries in the region and also the local government in Pasuruan Regency who understand and are related to this research. The methods used are the Delphi technique survey, the average descriptive statistical and the Analytical Hierarchy Process (AHP) to determine the priority factors for the success of the GIE perspective. As a result, success factors in developing green industrial areas must be supported by several factors, including: clean technological innovation; waste management, operational standard systems; sustainability of Corporate Social Responsibility (CSR); availability of energy, raw materials, water, infrastructure and technology; and the existence of legal certainty and security are the main important factors in driving the success of industrial estates into green industrial estates.
Preliminary study on preparing carboxymethyl cellulose–keratin biofilm
Authors: Adi Y W , Ekatiwi S , Suharti S 
Published: May 2020

Abstract
Keratin is a structural protein. Keratin can be obtained from chicken feathers. At present, chicken feathers are one of the great potentials of waste because of its abundance and cheap price. CMC has a similar structure to cellulose. Cellulose is very abundant in nature and its existence as waste and CMC is a derivative of natural cellulose polymers that are easily degraded. This paper reports our preliminary work on developing novel composite biofilm from both natural biopolymers to provide novel environmentally friendly biomaterials. Keratin solution was prepared from chicken feathers by the acid method. Variations in the number of CMCs were used to see differences in biofilm rigidity. The size of soluble keratin was measured using PSA, surface topography of biofilms was observed using SEM and FTIR was used to observe the presence of keratin embedded in biofilms. Based on the results of the PSA analysis, the size of soluble keratin was 1570.8 ± 26.30437 nm. FTIR analysis of CMC-keratin biofilm content showed an absorption peak in the area of 1240 cm-1 - 1546 cm-1 which the signature of an amide band which confirms the presence of keratin (protein) in the biofilm. SEM showed the surface structure of CMC-keratin biofilms forming a fibrous pattern. In this study, we concluded that CMC-keratin biofilm was generated, and it potentially can be developed further to generate environmentally friendly biomaterials.
Effects of tetM gene instability on resistance expression in Lactobacillus casei
Authors: Silvian S D , Haq H S I , Nabila F C , Wardani A K 
Published: May 2020

Abstract

Lactobacillus casei is one of the probiotic bacteria which has an antibiotic (tetracycline) resistance encoded by tetM gene. This gene can be unstable which leads to the changes of the DNA sequence (mutation) during the adaptation process under a sub-lethal dose of tetracycline antibiotic. The aim of the study is to observe the resistance level and genetic instability of tetM gene under a sub-lethal dose of tetracycline antibiotic and to examine the effect of gene instability on the antibiotic resistance level of L. casei. This study was conducted by 2 steps i.e. determination of sub-lethal dose of L. casei and isolation of L. casei with the highest resistance to tetracycline using adaptation process. This study confirmed that L. casei could survive with sub-lethal dose of 10-50 µg/mL tetracycline and has a lethal dose at 60 µg/mL. The concentration of more than 60 µg/mL tetracycline caused instability of tetM gene and lead to the survival of L. casei at 70 µg/mL tetracycline after adaptation process.
Isolation, screening and identification of potential cellulolytic and xylanolytic mold from oil palm waste
Authors: Kusumawati N , Wardani A K , Zubaidah E , Sumarlan S H 
Published: May 2020

Abstract
The objective of this research was to isolate, screen, and identify the cellulase and xylanase-producing mold from oil palm waste. There are thirty-two isolates from oil palm waste which are able to degrade and grow on media containing cellulose or xylan as a sole carbon source. Screening to determine cellulolytic and xylanolytic activity was performed by paper disc diffusion method using Congo Red as an indicator. All the thirty-two mold isolates showed cellulolytic and xylanolytic activity with relative enzyme activity (ratio of hydrolysed zone diameter and diameter of colony growth) ranging from 1.04 to 1.62. Based on the macro- and micromorphology characteristics, these isolates were identified as genus Trichoderma, Aspergillus, Rhizopus, Tallaromyces and Penicillium, with the number isolates in each genus was 22, 4, 3, 2, and 1 respectively. The highest cellulolytic and xylanolytic activity was achieved from the isolate namely OPT1(4) which was identified as Talaromyces pinophilus using morphological and molecular analysis. Under the optimum condition (30°C, 72 hours) in liquid medium containing carboxymethyl cellulose (CMC) and birch wood xylan as the main carbon source, Talaromyces pinophilus OPT1(4) presented glucanase and xylanase activity of 15.17 U/mL and 13.35 U/mL, respectively.
Characteristics of alkaline thermostable mannanase isolated from limestone microorganism
Authors: Sutrisno A , Mawarddatur S , Widyastuti E 
Published: May 2020

Abstract
Mannanase is the main enzyme that catalyses depolymerisation of ß-1,4 mannosidic linkages within the main chain of mannan releasing manno-oligosacharides. Since mannan is most soluble in alkaline solution and industrial enzyme applications prefer high thermostability, therefore mannanase with alkaline and high thermostability is more desired. The aims of this study were to isolate mannanase-producing microorganisms and to characterise the mannanase that obtained from partial purification. Nine mannolytic isolates were found and the chosen isolate was R311 with mannolytic index of 3.287. The purity of the enzyme from partial purification was 6.06-fold with the specific activity of 61.54 U/mg. Molecular mass of the mannanase analyzed by electrophoresis and zymogram was 32.39 kDa. The optimal temperatures and pH were 65°C and pH 8, respectively. The enzyme was stable at pH 5 – 8 and temperature up to 75°C. This property make mannanase R311 an attractive enzyme for biotechnological application for industries.
Tree traits that define timber ideotypes of Gmelina arborea Roxb.
Authors: Vallesteros S F 
Published: May 2020

AbstractGmelina (Gmelina arboreaRoxb.) is the most widely planted tree species in the province of Nueva Vizcaya, Philippines. Its role in local wood supply becomes more important as a consequence of the ban on harvesting naturally growing timber. More than 90% of the wood supply, based on reported transactions in 2013, is gmelina. Wood is coming from different planting configurations such as solitary trees, home gardens, road sides, riparian strips, small stands, and large plantations. While gmelina appears to be the most important tree in meeting local demand for wood, the yield per hectare is low due to poor tree management and mismatch between species and site. Results indicate great potentials for tree improvement with effort coming from the tree owners themselves and supported by scientific approach in tree improvement. Research on ideotype, or conceptual model of an ideal plant, promises to play a key role. The study worked on gmelina timber ideotype. Between-tree-traits relationships were investigated in order to see what traits might be subjected for simultaneous improvement. Significant relationships came out that would lead to defining the desired tree forms. Not a single form shall come out as combination of traits may result in increased in wood yield in tree or stand.
Optimisation of bleaching time and H2O2 concentration of handmade paper from Areca catechu L. fibre
Authors: Dewi I A , Wijana S , Royyani D E , Deoranto P , Ihwah A , Romas M S , Sunyoto N M S , Setyawan H Y 
Published: May 2020

Abstract
Areca nut (Areca catechu L.) is a type of palm used for commercial purposes because all parts of the plant -have high economic value. Areca nut fibre contains 53.2% cellulose and therefore, it can potentially be used as raw material for pulp for paper craft. Bleaching is conducted in order to make colourful paper craft. Some factors to be taken into account while bleaching the paper craft are levels of chemicals used for bleaching and length of bleaching time. The purpose of this study was to determine H2O2 level and optimum bleaching time to create quality paper from areca fibres and cardboard paper. Quality of the paper was evaluated based on tensile strength, thickness, grammage and brightness. Response surface method (RSM) is implemented optimize the estimated response. The model used in RSM is CCD (Central Design Composite) with 2 factors, namely bleaching time and H2O2. The upper and lower limit for the first factor were 90 and 150 minutes consecutively. Those for the second factor were 5% and 15% respectively. The evaluate responses were tensile strength and brightness level. The findings showed that the most suitable combination was 150-minutes bleaching time and 15% H2O2. The combination resulted in 69.50% brightness and 14.71 kN/m2 tensile strength. In addition, the paper grammage was 282 gr/cm2, its thickness was 0.88 mm and the moisture content was 6.5.
Benefit-cost for selecting technology in salt production
Authors: Maflahah I , Asfan  
Published: May 2020

AbstractThis paper discusses the costs of choosing the technology for the salt production process using the Analytical Hierarchy Process (AHP) technique. The strength of the strategy to the selection of production process technology based on the benefit-cost ratio by several criteria. The choice of salt production technology is traditional techniques, tunnelling techniques, prism techniques, and FDS (Flow down system) techniques. The AHP structures are the criteria and sub-criteria. AHP criteria give impacts such as production process technology, salt quality, production costs, and human resources. From these criteria, the cost of investment modal and maintenance have the highest weight — the quality of salt determined by the colour, NaCl content, and size of the salt granules. The criteria for production costs consist of sub-criteria for raw material costs, capital investment costs, and indirect costs. The level of technology is conventional technology, semi-modern technology, and modern technology. Human resources are the experience of farmers in processing salt production. The production costs needed for the salt production process greatly determine the farmer decision to obtain the optimal quality and quantity of salt. The second priority is the ease of production process technology and successively the following criteria as human resources and the quality of the salt produced. The recommended technology for production process based on AHP by using B/C ratio and consideration as indicators are tunnel and prism techniques.
Identification of parameters for the hybrid electrical energy storage system in autonomous power system
Authors: Eroshenko S.A. , Nesterenko G. B. , Zyryanov V. M. , Kiryanova N. G. , Prankevich G. A. 
Published: May 2020

Abstract
The article describes the approach to the selection of parameters of a hybrid electrical energy storage system (EESS) based on supercapacitors (SC) and lithium ion battery (LIB) for an autonomous power station with a diesel generator set (DGS). The calculations of transients in an autonomous power supply system with an abruptly variable load and participation of a hybrid EESS. The procedure of determining the share of participation in the energy exchange of storage subsystems based on LIB and SC is presented.
Digital twin process and simulation operation control technology for intelligent manufacturing unit
Authors: He Yichao , Zhang Niansong , Wang Aimin 
Published: May 2020

Abstract
In the manufacturing process, the intelligent manufacturing unit will produce unexpected situations with different forms and a large amount of data. How to control the intelligent manufacturing unit more intuitively and effectively control the operation and control of the trolley is an urgent problem to be solved. This paper proposes a digital twin process and simulation operation control technology for intelligent manufacturing units, including virtual workshop and actual workshop real-time mapping technology and digital twin-based simulation control technology. Through these two technical means, intelligent manufacturing unit realized visual real-time management and control. In the end, the author designed an intelligent manufacturing unit management system to successfully verify the effectiveness of the above technology.
The Talbot effect in self-assembled red blood cells investigated by digital holography
Authors: Memmolo Pasquale , Miccio Lisa , Merola Francesco , Ferraro Pietro 
Published: May 2020

Abstract
The Talbot effect, also known as self-imaging, is a well-established phenomenon observed when a beam of light is transmitted through a periodic pattern and the image of the pattern is reproduced at a regular interval along the optical axis, namely the Talbot length. This effect has been widely investigated and exploited for several applications in different fields. Here we discuss for the first time, to the best of our knowledge, the self-imaging effect due to a self-assembled and quasi-ordered array of live biological cells under illumination by a coherent light beam. In particular, self-assembly of red blood cells (RBCs) provides a monolayer of cells that appear to be quasi-ordered in a trigonal array geometry. Thanks to the recent proof that RBCs can be modeled as a microlens array, the Talbot length can be predicted and the corresponding self-imaging can be observed experimentally. In particular, we investigate the Talbot effect of self-assembled RBC arrays for two different RBC body shapes, i.e. discocytes and spherocytes, by using digital holography as tool for imaging and quantifying this phenomenon. This research could open up a new way to investigate biological material by exploiting its photonics properties.
Independent Evolutionary Responses to Quaternary Landscape and Climatic Changes of Two Codistributed Cactophilic Drosophila Species (Drosophila repleta group) in Open Areas of South America
Authors: Reginato Koser Jaqueline , Barrios-Leal Dora Yovana , Menezes Rodolpho S T , Manfrin Maura Helena 
Published: May 2020

AbstractEvolutionary processes related to climatic changes and ecological factors, such as microhabitat affinities and food specialization, can be important contributors to phylogeographic discordance between codistributed and related species. Here, we evaluate the evolutionary histories of two cactophilic and codistributed Drosophila species (Diptera: Drosophilidae) from South America, Drosophila antonietae and Drosophila meridionalis, where they use mainly Cereus hildmaniannus (Cactoideae: Cereeae) as host, using mitochondrial DNA sequences and species distribution modeling. The diversification of both species was estimated during the Pleistocene. For both species, the distribution of suitable areas through the Last Glacial period to the present showed a similar dynamic from Andes Valley through east and through the Paraná-Paraguay river basin to the Atlantic coastline. The current distribution of D. antonietae was influenced by demographic expansion and putative migration route from northwest to south and then to coast, with two genetic incipient groups with bidirectional genetic flow between them. For D. meridionalis, we suggested a migration route from south to north as well as to coast, with three genetic groups deeply structured with no evidence of demographic expansion. Our comparative results showed that the Quaternary paleoclimatic dynamic has had a similar role in both species (displacement of the high suitability areas) with similar routes but in different directions. Additionally, the Araucaria forest represents a putative biogeographic barrier for Drosophila species and also for host C. hildmaniannus. The phylogeographical differences between these species related to geographical distribution, genetic structure, and demographic history could be explained for differences to adaptation and plasticity to explore a new host.
Diagnosing serious infections in older adults presenting to ambulatory care: a systematic review
Authors: Struyf Thomas , Boon Hanne A , van de Pol Alma C , Tournoy Jos , Schuermans Alexander , Verheij Theo J M , Verbakel Jan Y , Van den Bruel Ann 
Published: May 2020

Abstract

Objectives
to summarise all available evidence on the accuracy of clinical features and blood tests for diagnosing serious infections in older patients presenting to ambulatory care.

Methods
systematic review, searching seven databases using a comprehensive search strategy. We included cross-sectional prospective diagnostic studies on (1) clinical features, (2) diagnostic prediction rules based on clinical features alone, (3) blood tests and (4) diagnostic prediction rules combining clinical features and blood tests. Study participants had to be community-dwelling adults aged ≥65 years, in whom a physician suspected an infection. We used QUADAS-2 to assess risk of bias. We calculated measures of diagnostic accuracy and present descriptive statistics.

Results
out of 13,757 unique articles, only six studies with a moderate to high risk of bias were included. There was substantial clinical heterogeneity across these studies. Clinical features had LR− ≥0.61 and LR+ ≤4.94. Twelve prediction rules using clinical features had LR− ≥0.30 and LR+ ≤2.78. There was evidence on four blood tests of which procalcitonin was the most often investigated: levels &lt;0.37 ng/ml (LR− = 0.20; 95%CI 0.10–0.42) were suitable to rule out sepsis in moderately high prevalence situations. Two diagnostic prediction rules combining clinical features and procalcitonin had LR− of ≤0.12 (95%CI 0.05–0.33) and LR+ of maximum 1.39 (95%CI 1.30–1.49).

Conclusions
we found few studies on the diagnostic accuracy of clinical features and blood tests to detect serious infections in older people presenting to ambulatory care. The risk of bias was mostly moderate to high, leading to substantial uncertainty.
Differential Effects of Saikosaponins A, B2, B4, C and D on Alcohol and Chocolate Self-Administration in Rats
Authors: Maccioni Paola , Lorrai Irene , Fara Federica , Carai Mauro A M , Gessa Gian Luigi , Chin Young-Won , Lee Jung Hwan , Kwon Hak Cheol , Corelli Federico , Colombo Giancarlo 
Published: May 2020

Abstract

Aims
Treatment with saikosaponin A (SSA)—an ingredient of the medicinal herb, Bupleurum falcatum—has been reported to suppress several addictive-like behaviors, including morphine, cocaine, alcohol and chocolate self-administration in male rats. The aim of this investigation was to investigate whether saikosaponins of B. falcatum other than SSA affect alcohol and chocolate self-administration in rats.

Methods
Ovariectomized female Sardinian alcohol-preferring (sP) and Wistar rats were trained to self-administer alcohol (15%, v/v) and a chocolate solution [5% (w/v) Nesquik® in water], respectively, under fixed ratio schedules of reinforcement. The following saikosaponins were compared to SSA: saikosaponin D (SSD; epimer of SSA), saikosaponin C (SSC), saikosaponin B2 (SSB2) and saikosaponin B4 (SSB4). All saikosaponins were tested acutely at the doses of 0, 0.25, 0.5 and 1 mg/kg (i.p.).

Results
Treatment with SSA and SSD resulted in highly similar, marked reductions in alcohol self-administration; SSC failed to alter lever-responding for alcohol, while SSB2 and SSB4 produced intermediate reductions. Only SSA and SSD reduced chocolate self-administration, with SSC, SSB2 and SSB4 being ineffective.

Conclusions
The wide spectrum of efficacy of saikosaponins in reducing alcohol and chocolate self-administration suggests that even relatively small structural differences are sufficient to produce remarkable changes in their in vivo pharmacological profile. Together, these results confirm that roots of B. falcatum may be an interesting source of compounds with anti-addictive potential.
Alcoholics Anonymous and 12-Step Facilitation Treatments for Alcohol Use Disorder: A Distillation of a 2020 Cochrane Review for Clinicians and Policy Makers
Authors: Kelly John F , Abry Alexandra , Ferri Marica , Humphreys Keith 
Published: May 2020

ABSTRACT

Aims
A recently completed Cochrane review assessed the effectiveness and cost-benefits of Alcoholics Anonymous (AA) and clinically delivered 12-Step Facilitation (TSF) interventions for alcohol use disorder (AUD). This paper summarizes key findings and discusses implications for practice and policy.

Methods
Cochrane review methods were followed. Searches were conducted across all major databases (e.g. Cochrane Drugs and Alcohol Group Specialized Register, PubMed, Embase, PsycINFO and ClinicalTrials.gov) from inception to 2 August 2019 and included non-English language studies. Randomized controlled trials (RCTs) and quasi-experiments that compared AA/TSF with other interventions, such as motivational enhancement therapy (MET) or cognitive behavioral therapy (CBT), TSF treatment variants or no treatment, were included. Healthcare cost offset studies were also included. Studies were categorized by design (RCT/quasi-experimental; nonrandomized; economic), degree of manualization (all interventions manualized versus some/none) and comparison intervention type (i.e. whether AA/TSF was compared to an intervention with a different theoretical orientation or an AA/TSF intervention that varied in style or intensity). Random-effects meta-analyses were used to pool effects where possible using standard mean differences (SMD) for continuous outcomes (e.g. percent days abstinent (PDA)) and the relative risk ratios (RRs) for dichotomous.

Results
A total of 27 studies (21 RCTs/quasi-experiments, 5 nonrandomized and 1 purely economic study) containing 10,565 participants were included. AA/TSF interventions performed at least as well as established active comparison treatments (e.g. CBT) on all outcomes except for abstinence where it often outperformed other treatments. AA/TSF also demonstrated higher health care cost savings than other AUD treatments.

Conclusions
AA/TSF interventions produce similar benefits to other treatments on all drinking-related outcomes except for continuous abstinence and remission, where AA/TSF is superior. AA/TSF also reduces healthcare costs. Clinically implementing one of these proven manualized AA/TSF interventions is likely to enhance outcomes for individuals with AUD while producing health economic benefits.
A song turned sideways would sound as sweet
Authors: Ferguson Zachary 
Published: May 2020

AbstractMarkosian (2020) presents an argument against certain theories of time based on the aesthetic value of music. He argues that turning a piece of music sideways in time destroys its intrinsic value, which would not be possible if the Spacetime Thesis were true. In this paper I show that sideways music poses no problems for any theory of time by demonstrating that turning a piece of music sideways does not affect its intrinsic value. I do this by appealing to spatial analogies that highlight the similarities between spatial and temporal rotations.