bluuebunny/crossref_metadata_2025_split huggingface dataset:
Machine learning and network medicine: a novel approach for precision medicine and personalized therapy in cardiomyopathies
Authors: Infante Teresa , Francone Marco , De Rimini Maria L. , Cavaliere Carlo , Canonico Raffaele , Catalano Carlo , Napoli Claudio 
Published: September 2020

The early identification of pathogenic mechanisms is essential to predict the incidence and progression of cardiomyopathies and to plan appropriate preventive interventions. Noninvasive cardiac imaging such as cardiac computed tomography, cardiac magnetic resonance, and nuclear imaging plays an important role in diagnosis and management of cardiomyopathies and provides useful prognostic information.
Most molecular factors exert their functions by interacting with other cellular components, thus many diseases reflect perturbations of intracellular networks. Indeed, complex diseases and traits such as cardiomyopathies are caused by perturbations of biological networks. The network medicine approach, by integrating systems biology, aims to identify pathological interacting genes and proteins, revolutionizing the way to know cardiomyopathies and shifting the understanding of their pathogenic phenomena from a reductionist to a holistic approach.
In addition, artificial intelligence tools, applied to morphological and functional imaging, could allow imaging scans to be automatically analyzed to extract new parameters and features for cardiomyopathy evaluation. The aim of this review is to discuss the tools of network medicine in cardiomyopathies that could reveal new candidate genes and artificial intelligence imaging-based features with the aim to translate into clinical practice as diagnostic, prognostic, and predictive biomarkers and shed new light on the clinical setting of cardiomyopathies. The integration and elaboration of clinical habits, molecular big data, and imaging into machine learning models could provide better disease phenotyping, outcome prediction, and novel drug targets, thus opening a new scenario for the implementation of precision medicine for cardiomyopathies.
Ventricular arrhythmias in Takotsubo Syndrome: incidence, predictors and clinical outcomes
Authors: Pelargonio Gemma , La Rosa Giulio , Di Stasio Enrico , Narducci Maria Lucia , Rocco Erica , Angelini Alessio , Pinnacchio Gaetano , Bencardino Gianluigi , Perna Francesco , Comerci Gianluca , Catania Fiammetta , Crea Filippo 
Published: September 2020

Aims
To investigate predictors of the occurrence of subacute ventricular arrhythmias (VAs), defined as any VAs presenting after 48 h from admission in patients with Takotsubo Syndrome (TTS), and to evaluate the related in-hospital mortality.

Methods
This is a retrospective single-center study enrolling patients admitted between 2012 and 2017 with TTS according to International Takotsubo diagnostic criteria. Data collection included ECG on admission and at 48 h, telemetry monitoring and transthoracic echocardiogram.

Results
We enrolled 93 patients; during in-hospital stay (mean 14 ± 16 days) subacute VAs occurred in 25% of patients (VAs group). Life-threatening VAs occurred in 6% of patients (3 sustained ventricular tachycardia, 1 torsade de pointes, 1 ventricular fibrillation) and not life-threatening VAs in 19% (6 non-sustained ventricular tachycardia and 12 premature ventricular contractions > 2000 in 24 h). Mortality was higher in the VAs than in the non-VAs group (P = 0.03), without differences in terms of life-threatening and not life-threatening subacute VAs (P = 0.65) and VAs on admission (P = 0.25). Logistic regression identified the following independent predictors of subacute VAs occurrence: VAs on admission {odds ratio [OR] 22.5 (3.9–131.8), P = 0.001]}, New York Heart Association (NYHA) class III–IV on admission [OR 6.7 (1.3– 34.0), P = 0.021] and QTc at 48 h [OR 1.01 (1.00–1.03), P = 0.046].

Conclusion
TTS patients with VAs and NYHA class III–IV on admission and higher QTc at 48 h are at increased risk of subacute VAs occurrence, associated with higher in-hospital mortality. Awareness of this potential complication is critical for proper patients management.
O CONTRATO SOCIAL BRASILEIRO VERSUS AS TEORIAS NEOCONTRATUALISTAS MODERNAS
Authors: PEREIRA Juliano Gil Alves , SANTANA Paulo Ricardo , OLIVEIRA Pedro César Sousa 
Published: September 2020

O presente trabalho busca analisar comparativamente os principais aspectos da Constituição da República Federativa do Brasil, de 1988, com as teorias neocontratualistas igualitária, libertária e marxista analítica objetivando averiguar se a Carta Magna, compreendida como pacto social brasileiro, se aproxima ou contempla alguma das teorias sociais modernas. Sendo uma pesquisa descritivo-explicativa, com abordagem qualitativa e de vertente jurídico-dogmática, adotou-se o método de análise comparativo. Utiliza-se a teoria igualitária de John Rawls, expondo os conceitos de liberalismo igualitário e Constituição Justa; a teoria libertária nozickiana, compreendendo as dimensões do Estado Mínimo; e a teoria marxista analítica, com os conceitos empíricos-marxistas e a justiça proletária. Os resultados aparecem de maneira discrepante sendo a teoria igualitária a que mais se aproxima, comparativamente, da Constituição da República, ao passo que as demais diferem de questões essenciais do documento jurídico-político brasileiro. Conclui-se que a Constituição Federal possui caráter eclético e, contemplando diversas disposições das teorias modernas neocontratualistas, aproxima-se mais da teoria igualitária.

BRAZILIAN ARTICLES OF ASSOCIATION VERSUS MODERN NEOCONTRACTUALISM THEORIES

ABSTRACT
The present paper seeks to comparatively review the main aspects of the Constitution of the Federative Republic of Brazil, from 1988 to egalitarian neo-contractualism, libertarian and analytical Marxism theories, it aims at determining if the Magna Carta, construed as a Brazilian social contract, approaches or deliberates any modern social theory. It is descriptive-explanatory research, with qualitative, and legal-dogmatic approaches, the comparative analysis method was adopted. The paper draws on John Rawls's egalitarian theory, describing the concepts of egalitarian liberalism and Just Constitution; Nozick libertarian justice theory including the dimensions of Minima State; and analytical Marxist theory, within empirical Marxist concepts, and proletarian justice. The results were disparate, being the egalitarian theory the closest one when comparing it to the Constitution of the Republic, whereas the other theories differ from the key issues of Brazilian legal political document. It was concluded that the Federative Constitution has eclectic purposes, covering several neocontractualist modern theories clauses, mostly approaching the egalitarian theory.

keywords: Egalitarianism. Libertarianism. Analytical Marxism. Equity.
CLINICAL AND SUBCLINICAL FEATURES OF PEDIATRIC PATIENTS WITH HEPATOBLASTOMA AT NATIONAL CHILDREN HOSPITAL
Authors: Pham Duy Hien 
Published: September 2020

Background: Hepatoblastoma is the most common malignant liver tumor in children. Aims: Study on clinical and subclinical features of pediatric patients with hepatoblastoma at National Children Hospital from 1/2016 to 8/2019. Materials and Methods: A total patients with operated Hepatoblastoma diagnosed by pathologists, at the Viet Nam National Children’s Hospital from January 2016 to August 2019. The study design is retrospective. Resullts: Study subject’s mean of age was 36,8 months (range 4 – 149 months), the common group of age was under 5 years old (76,7%), male’s more than female (56,7% and 43,3%). The most common clinical symptoms were hepatomegaly (50%), a palpable abdominal mass (30%), abdominal pain (13,3%), secondary anemia (13,3%), weight loss (6,7%), jaundice (3,3%). About laboratory test: 83,3% patients with anemia, 36,7% patients with thrombocytosis, 90% patients with hight GOT levels, 53,3% patients with hight GPT levels, 96,7% patients with hight serum AFP levels and the average value of AFP was 217160,7 ng/ml (range 575 – 1686328,6 ng/ml). Mean size of the tumor on computerized tomography was 5,48cm (range 2 – 15cm), 60% size of tumor ≤ 5cm, 96,7% had only one tumor, 70% primary tumor located to the right lobe of the liver, 76,7% were staged PRETEXT II, the most common hepatoblastoma histopathological subtypes was as follows: epithelial (80%). Conclusion: Clinical symptoms of hepatoblastoma are usually nonspecific. A routine check – up strategy for early detection of hepatoblastoma and the role of subclinical aids in diagnosis is very important.
The Management of Facilities and Infrastructure Based on Management Information System Applications for Goods Owned by State (SIMAK-BMN)
Authors: Rumiari Rumiari , Wahyudi Wahyudi , Chiar Muhammad 
Published: September 2020

<strong>Abstract<em>.</em> </strong>The management weakness of facilities and infrastructure in implementing the application of the State Property Management Information System (SIMAK BMN) is the cause of lack of optimal management of facilities or infrastructure or the application of SIMAK BMN by the school principal in empowering education staff and stakeholders within the madrasa. The purpose of this study was to describe the management of application-based infrastructure and State-Owned Management Information System (SIMAK BMN). The approach used in this study was qualitative research with a type of case study research. The stages in this study consisted of field, field and data processing. Data analysis takes place together with the process of collecting data, reducing data, presenting data, and drawing conclusions/verification. The results obtained in this study were (1) Planning of facilities and infrastructure made by madrasas provides an overview of the planning of needs achieved in the purpose of education; (2) Organizing application-based facilities and infrastructure SIMAK BMN in MTsN 1 Singkawang shoed a positive tendency to implement mechanisms, tasks and organizing functions that are conveyed to all teachers; (3) The implementation of SIMAK BMN application-based facilities and infrastructure at MTsN 1 Singkawang showed a tendency to be less than optimal; (4) Monitoring of application-based facilities and infrastructure SIMAK BMN at MTsN 1 Singkawang showed the tendency to carry out internal reconciliation, external reconciliation and pertangungjawban through semester reports. Therefore, it can be concluded, the management of facilities and infrastructure based on the application of the State Owned Management Information System (SIMAK BMN) at MTsN 1 Singkawang was an attempt to curb the recording of application-based infrastructure through the management of Property Management Information System functions. Country (SIMAK BMN).
C-reactive protein and procalcitonin - laboratory markers of degrees of severity and complications of an acute necrotic pancreatitis
Authors: Rotar O. V. , Khomiak I. V. , Rotar V. I. , Khomiak A. I. , Railianu S. I. 
Published: September 2020

Objective. To conduct comparative estimation of efficacy of C-reactive protein and procalcitonin as laboratory markers for stratification of the patients severity state suffering an acute necrotic pancreatitis.
Materials and methods. Prospective cohort investigation, including 151 patients with an acute necrotic pancreatitis, was conducted. Clinical, laboratory and bacteriological investigations were accomplished. The levels of C-reactive protein and procalcitonin were determined in the blood plasm.
Results. The necrotic accumulations infectioning was diagnosed in 89 (58.9%) patients: local purulent complications - in 27, sepsis - in 33,septic shock - in 29. In 62 patients with sterile pancreonecrosis a C-reactive protein concentration have raised from (5.6 ± 0.89) to (206 ± 29) mg/l (p˂0.001). Development of purulent-septic complications was accompanied by significant and trustworthy (p<0.01) elevation of procalcitonin concentration: in the patients with sepsis - up to (5.05 ± 0.92) ng/ml, in the patients with septic shock - up to (7.25 ± 2.15) ng/ml.
Conclusion. Simultaneous measurement of levels of C-reactive protein and procalcitonin in the blood plasm in patients, suffering acute necrotic pancreatitis, gives permission to determine the inflammatory process character and stratify the disease severity in its early terms.
Comparative Evaluation of Hyoid Bone Position and Tongue Area with Twin Block and Forsus: A Randomized Clinical Trial
Authors: Rajput Raksha , Daokar Suchita 
Published: September 2020

Introduction: Class II div 1 malocclusion is most commonly presented with retruded mandible. This backward placement of mandible pushes the tongue posteriorly and inturn impairs the position of hyoid bone and total tongue area. Correction of retruded mandible with functional appliances is also considered to have positive effect on hyoid bone position and tongue area. Aim and Objectives: The objective of this study was to evaluate and compare the effects of Twin Block and Forsus on the hyoid bone position and tongue area in the treatment of Class II division 1 malocclusion.
Materials & Method: A 2-arm parallel, randomized controlled trial was designed consisting of 24 Class II division 1 malocclusion patients indicated for treatment with functional appliances. 24 patients were randomized and equally divided among Twin Block (Group A) and Forsus (Group B) group. Pre- and post functional lateral cephalograms of both groups were traced and statistically analysed using paired t-test and T test of Equality of Means. ‘p’ value of less than 0.05 was considered as statistically significant.
Result: A significantly upward and forward movement of hyoid bone was found with both the appliances. Tongue area also improved with Twin Block and Forsus group. On intergroup comparison insignificant results were observed between both the appliances indicating similar effect on tongue area and hyoid bone position.
Conclusion: Twin Block has more skeletal effect than Forsus, still both Twin Block and Forsus are effective in improving tongue area and forward and upward displacement of hyoid bone position while correcting Class II malocclusion.
Crack divergence phenomena in tempered glass
Authors: Aratani Shin’ichi 
Published: September 2020

High speed photography using the Cranz-Schardin camera was performed to study the crack divergence and divergence angle in thermally tempered glass. A tempered 3.5 mm thick glass plate was used as a specimen. It was shown that two types of bifurcation and branching existed as the crack divergence. The divergence angle was smaller than the value calculated from the principle of optimal design and showed an acute angle.
Designing Life Skill School in Nelayan Seberang Village with Ecological Architecture Approach
Authors: Ulfatun Fitri Kusumah  , Rudolf Sitorus  
Published: September 2020

This journal is essential for social, education, and economical in Nelayan Seberang Village. It is about difficult access to schools, low-interest in learning, and economic problems that are part of the factors causing the low level of education of the peoples of Nelayan Seberang Village. The aim is to make it easier for the fishing village community to access educational facilities and increase the level of education of Nelayan Seberang Villagers. The method used in site selection is done through a discussion of primary data. Data sources that directly provide data to data collectors, and secondary data, that is data that does not directly provide data to researchers, through other people or analyzed documents and concluded. The result of the methodology used is Procurement of Life Skills Schools is a practical solution to these problems. Students invited to explore the potential around, manage it, and at the same time, market their products in one place. The ecological architecture applied to this building in such a way that the building can sustain in areas affected by tides and at the same time can reduce negative impacts on the environment. The school buildings designed to friendly to the villagers of Nelayan Seberang Village. So that it can attract peoples to come to school. This is useful to increase the interest in the education of Nelayan Seberang Villagers.
Pengaruh Halte Bus Trans Semarang terhadap Kinerja Lalu Lintas Pada Jalan 2/2 TT (Studi Kasus: Jalan Dokter Wahidin)
Authors: Setiawan Ari 
Published: September 2020

Bus Trans Semarang merupakan salah satu moda transportasi umum yang diterapkan di Kota Semarang dan diharapkan mampu mengurangi kepadatan dan kemacetan lalu lintas. Pengoperasian Bus Trans Semarang masih menimbulkan beberapa kendala yaitu Halte Bus Trans Semarang tidak dilengkapi teluk bus. Tujuan dari penelitian ini adalah menganalisis pengaruh keberadaan Halte Bus Trans Semarang terhadap kinerja lalu lintas. Metode analisis pengaruh kinerja lalu lintas yang digunakan adalah membandingkan kecepatan, kepadatan, derajat kejenuhan pada lokasi ada halte dengan tanpa halte. Hasil perhitungan pada lokasi dimana ada halte saat Bus Trans Semarang berhenti (v = 48.353 km/jam, k = 6.669 smp/km dan Dj = 0.913), ada halte saat Bus Trans Semarang tidak berhenti (v = 50.617 km/jam, k = 5.575 smp/km dan Dj = 0.668) dan tanpa halte (v = 51.555 km/jam, k = 4.117 smp/km dan Dj = 0.543). Kesimpulan yang diperoleh, keberadaan Halte Bus Trans Semarang dapat menurunkan kinerja lalu lintas diperburuk pada saat Bus Trans Semarang berhenti di halte.
Hubungan Personal Hygiene dengan Kejadian Skabies di Pondok Pesantren Madani Unggulan, Kabupaten Bintan
Authors: Samosir Kholilah , Sitanggang Hendra Dhermawan , MF M. Yusuf 
Published: September 2020

Skabies merupakan penyakit menular yang masih menjadi masalah kesehatan masyarakat. Scabies adalah penyakit kulit yang disebabkan infestasi dan sensitisasi tungau Sarcoptes scabiei. Penyakit scabies umumnya menyerang individu yang hidup berkelompok seperti asrama dan pesantren. Prevalensi scabies di Pondok Pesantren Madani Unggulan Kab.Bintan dari tahun ketahun meningkat dari 35 menjadi 40 orang, dan tahun 2018 masih terdapat 20 orang. Hal ini dikarenakan faktor lingkungan dan personal hygiene yang tidak bersih. Tujuan penelitian untuk mengetahui hubungan personal hygiene dengan kejadian scabies di Pondok Pesantren Madani Unggulan Kecamatan Toapaya Kabupaten Bintan. Penelitian ini menggunakan desain cross sectional di Pondok Pesantren Madani Unggulan Kecamatan Toapaya Kabupaten Bintan Tahun 2018. Jumlah populasi dan sampel dalam penelitian ini adalah seluruh siswa sebanyak 106 Siswa dengan teknik sampel jenuh. Hasil responden yang mengalami kejadian skabies sebesar 18,9%. Hasil analisis multivariat dengan uji regresi logistik dikontrol variabel jenis kelamin dan ventilasi yang merupakan variabel konfounder dalam hubungan personal higiene dengan kejadian scabies dan merupakan sebagai faktor risiko terhadap kejadian skabies dengan nilai aPR=3,447 (95%CI : 0,973-12,215). Hal ini dikarenakan penularan skabies yang dapat terjadi secara langsung melalui jabat tangan dan skabies, khususnya di Pondok Pesantren.
Faktor-faktor yang Mempengaruhi Kualitas Hidup ODHA Terpapar Program OBRASS di Yayasan Pelita Ilmu Tahun 2020
Authors: Khairunniza Khairunniza , Saputra Nazarwin 
Published: September 2020

HIV dan AIDS telah menjadi masalah darurat global. Terdapat 36,9 juta orang yang hidup dengan HIV di seluruh dunia. Indonesia sendiri menempati urutan tertinggi ketiga jumlah orang dengan HIV/AIDS di dunia. Tingginya kasus HIV/AIDS sangat berpengaruh pada kualitas hidup ODHA, seperti meningkatnya kasus depresi pada ODHA. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang mempengaruhi kualitas hidup ODHA terpapar program OBRASS di Yayasan Pelita Ilmu Tahun 2020. Penelitian ini menggunakan desain studi cross-sectional dengan sampel 70 ODHA yang terpapar Program OBRASS. Penelitian dilakukan di Yayasan Pelita Ilmu pada bulan Maret – Juni tahun 2020. Teknik pengambilan sampel menggunakan total sampling. Analisis data yang digunakan adalah multiple regression logistic. Hasil penelitian ini menunjukkan bahwa faktor yang berpengaruh terhadap kualitas hidup ODHA terpapar program OBRASS di Yayasan Pelita Ilmu yaitu kepatuhan minum obat (Pv= 0,003; OR 6,459), lama terapi ARV (Pv=0,032; OR 3,503) dan depresi (Pv=0,006; OR=5,471). Dari ketiga faktor tersebut, faktor paling dominan berpengaruh adalah kepatuhan minum obat dengan nilai OR paling tinggi.
Pattern of Psychiatric Referral in a Tertiary Care Hospital in Bangladesh
Authors: Algin Sultana , Ahmed Sumaiya Nawsheen , Hossain Redwana 
Published: September 2020

Introduction: Consultation-liaison Psychiatry (CLP) is the study, practice and teaching of the relationbetween medical and psychiatric disorders.
Aim of the study: The aim of this study is to find out the referring department, reason for consultation,common psychiatric comorbidities and sociodemographic of the referred patients to psychiatrydepartment from the other departments of Bangabandhu Sheikh Mujib Medical University of Dhaka.
Methodology: This cross-sectional study was carried out from May 2018 to February 2020. Patientsreferred from different inpatient departments every Thursday were taken as study population.Psychiatric diagnoses of the patients were assigned by the consultant psychiatrist as per DSM-5criteria. Semi structured questionnaire was used to collect socio-demographic data.
Results: Among the referred patients (n= 89) 56% were female; 63% were aged between 19-59years; 65% were married; 58% were from urban background and 51% studied up to higher secondary.More than half of the patients were referred from different branches of Medicine (68%). Referral fromInternal Medicine was 14.6%, Rheumatology 13.5%, Neurology and Nephrology 10% respectively.The rest were from the branches of pediatrics, surgery and gynecology. Most common psychiatricdisorder was Major Depressive Disorder (37%) followed by Obsessive-Compulsive Disorder (17%)and Delirium (10.11%). 15% patient received no psychiatric diagnosis.
Conclusion: Psychiatric comorbidities in general medical illness are very common. CLP provides anopportunity to improve health outcomes for inpatients and reduce burden on the healthcare system.
Bangladesh J Medicine July 2020; 31(2) :76-80
How Political Is the Kantian Church?
Authors: Palmquist Stephen 
Published: September 2020

Commentators who lament that Kant offers no concrete guidelines for how to set up an ethical community typically neglect Kant’s claim in Religion that the ethical state of nature can transform into an ethical community only by becoming a people of God—i.e., a religious community, or “church.” Kant’s argument culminates by positing four categorial precepts for church organization. The book’s next four sections can be read as elaborating further on each precept, respectively. Kant repeatedly warns against using religious norms to control people. Accordingly, he explicitly forbids the true church from adopting any standard form of political governance; it must aim to be radically non-political. Nevertheless, churches organized according to Kant’s non-coercive theocratic model contribute something essential to the ultimate political goal of achieving perpetual peace and an end to war: by approaching the ultimate ethical goal (the highest good), the true church offers an antidote to normative fragmentation.