bluuebunny/crossref_metadata_2025_split huggingface dataset:
MCDA Index Tool: an interactive software to develop indices and rankings
Authors: Cinelli Marco , Spada Matteo , Kim Wansub , Zhang Yiwen , Burgherr Peter 
Published: July 2020

AbstractA web-based software, called MCDA Index Tool (https://www.mcdaindex.net/), is presented in this paper. It allows developing indices and ranking alternatives, based on multiple combinations of normalization methods and aggregation functions. Given the steadily increasing importance of accounting for multiple preferences of the decision-makers and assessing the robustness of the decision recommendations, this tool is a timely instrument that can be used primarily by non-multiple criteria decision analysis (MCDA) experts to dynamically shape and evaluate their indices. The MCDA Index Tool allows the user to (i) input a dataset directly from spreadsheets with alternatives and indicators performance, (ii) build multiple indices by choosing several normalization methods and aggregation functions, and (iii) visualize and compare the indices’ scores and rankings to assess the robustness of the results. A novel perspective on uncertainty and sensitivity analysis of preference models offers operational solutions to assess the influence of different strategies to develop indices and visualize their results. A case study for the assessment of the energy security and sustainability implications of different global energy scenarios is used to illustrate the application of the MCDA Index Tool. Analysts have now access to an index development tool that supports constructive and dynamic evaluation of the stability of rankings driven by a single score while including multiple decision-makers’ and stakeholders’ preferences.
Comparative proteomic analysis of drought and high temperature response in roots of two potato cultivars
Authors: Boguszewska-Mańkowska Dominika , Gietler Marta , Nykiel Małgorzata 
Published: July 2020

AbstractA comparative analysis of drought and high temperature responsive proteins, which means to provide insight into the molecular mechanism of potato stress tolerance. In the presented study, two potato cultivars, differing in dehydration tolerance, were compared. An analysis of their morphological, physiological and root proteome related traits proved that, although water shortage, as well as high temperatures cause the dehydration of plants, the response to those stresses at the proteome level was significantly different. LC–MS/MS protein identification showed that in roots of the sensitive cultivar, in response to drought, most changes concern increased abundance of defence- and detoxification-related proteins, while in tolerant plants, significant changes in abundance of energy and carbohydrate metabolism related proteins were observed (data are available via ProteomeXchange with identifier PXD020259). Moreover, in response to high temperatures, in the sensitive cultivar, decreased abundance of proteins involved in cell energetic metabolism was detected, while in the tolerant cultivar, the majority of proteins from this group was abundant. It can be suggested that such comparative proteome analysis indicates the fine tuning metabolism as a major factor of stress tolerance of potato plants.
Against Ulysses contracts for patients with borderline personality disorder
Authors: Lundahl Antoinette , Helgesson Gert , Juth Niklas 
Published: July 2020

AbstractPatients with borderline personality disorder (BPD) sometimes request to be admitted to hospital under compulsory care, often under the argument that they cannot trust their suicidal impulses if treated voluntarily. Thus, compulsory care is practised as a form of Ulysses contract in such situations. In this normative study we scrutinize the arguments commonly used in favour of such Ulysses contracts: (1) the patient lacking free will, (2) Ulysses contracts as self-paternalism, (3) the patient lacking decision competence, (4) Ulysses contracts as a defence of the authentic self, and (5) Ulysses contracts as a practical solution in emergency situations. In our study, we have accepted consequentialist considerations as well as considerations of autonomy. We conclude that compulsory care is not justified when there is a significant uncertainty of beneficial effects or uncertainty regarding the patient’s decision-making capacity. We have argued that such uncertainty is present regarding BPD patients. Hence, Ulysses contracts including compulsory care should not be used for this group of patients.
Manual segmentation versus semi-automated segmentation for quantifying vestibular schwannoma volume on MRI
Authors: McGrath Hari , Li Peichao , Dorent Reuben , Bradford Robert , Saeed Shakeel , Bisdas Sotirios , Ourselin Sebastien , Shapey Jonathan , Vercauteren Tom 
Published: July 2020

AbstractPurposeManagement of vestibular schwannoma (VS) is based on tumour size as observed on T1 MRI scans with contrast agent injection. The current clinical practice is to measure the diameter of the tumour in its largest dimension. It has been shown that volumetric measurement is more accurate and more reliable as a measure of VS size. The reference approach to achieve such volumetry is to manually segment the tumour, which is a time intensive task. We suggest that semi-automated segmentation may be a clinically applicable solution to this problem and that it could replace linear measurements as the clinical standard.MethodsUsing high-quality software available for academic purposes, we ran a comparative study of manual versus semi-automated segmentation of VS on MRI with 5 clinicians and scientists. We gathered both quantitative and qualitative data to compare the two approaches; including segmentation time, segmentation effort and segmentation accuracy.ResultsWe found that the selected semi-automated segmentation approach is significantly faster (167 s vs 479 s,$$p<0.001$$p<0.001), less temporally and physically demanding and has approximately equal performance when compared with manual segmentation, with some improvements in accuracy. There were some limitations, including algorithmic unpredictability and error, which produced more frustration and increased mental effort in comparison with manual segmentation.ConclusionWe suggest that semi-automated segmentation could be applied clinically for volumetric measurement of VS on MRI. In future, the generic software could be refined for use specifically for VS segmentation, thereby improving accuracy.
Investigation of using RFID for cure monitoring of glass fiber-reinforced plastics
Authors: Veigt Marius , Hardi Elisabeth , Koerdt Michael , Herrmann Axel S. , Freitag Michael 
Published: July 2020

AbstractFiber composite components play an important role in the turnaround in energy policy as well as in stopping global warming. Therefore, it is essential to improve the manufacturing efficiency of these components. RFID technology is spreading to digitize and organize processes in production and logistics more efficiently. Since cure monitoring is a crucial factor in the manufacturing of composite components, the question arises whether the RFID technology is applicable for cure monitoring. This paper presents two methods of how an into glass fiber-reinforced plastics integrated RFID transponder could monitor the curing. Following the assumption that the change in permittivity of the glass fiber-reinforced plastic during curing influence the RFID signal, experiments in a measuring chamber (low-interference environment) were conducted. It was investigated whether the optimal response frequency of the integrated RFID transponder changes and whether the received signal strength indicator (RSSI) changes at a specific frequency during curing. As a reference method, the dielectric analysis as a well-known method for cure monitoring was used and compared with the RFID measurements. The results indicate that the optimal response frequency remains constant but the RSSI increases and possess a very high linear correlation with the measurement of the dielectric analysis in a low-interference environment. Consequently, the RFID technology is applicable to monitor the curing of glass fiber-reinforced plastics by measuring the RSSI in a low-interference environment.
The outcome of pulmonary hypertension and its association with pulmonary artery dilatation
Authors: Duijnhouwer A. L. , Lemmers J. , Smit J. , van Haren-Willems J. , Knaapen-Hans H. , ten Cate T. , Hagmolen of ten Have W. , de Boer M.-J. , Roos-Hesselink J. , Vonk M. , van Dijk A. 
Published: July 2020

Abstract
Background
Pulmonary artery (PA) dilatation is often seen in pulmonary hypertension (PH) and is considered a long-term consequence of elevated pressure. The PA dilates over time and therefore may reflect disease severity and duration. Survival is related to the stage of the disease at the time of diagnosis and therefore PA diameter might be used to predict prognosis. This study evaluates the outcome of patients with pulmonary arterial hypertension (PAH) and chronic thrombo-embolic pulmonary hypertension (CTEPH) and investigates whether PA diameter at the time of diagnosis is associated with mortality.

Methods
Patients visiting an outpatient clinic of a tertiary centre between 2004 and 2018 with a cardiac catheterisation confirmed diagnosis of PAH or CTEPH and a CT scan available for PA diameter measurement were included. PA diameter and established predictors of survival were collected (New York Heart Association (NYHA) class, N‑terminal pro-brain natriuretic peptide (NT-proBNP) level and 6‑min walking distance (6MWD)).

Results
In total 217 patients were included (69% female, 71% NYHA class ≥III). During a median follow-up of 50 (22–92) months, 54% of the patients died. Overall survival was 87% at 1 year, 70% at 3 years and 58% at 5 years. The mean PA diameter was 34.2 ± 6.2 mm and was not significantly different among all the diagnosis groups. We found a weak correlation between PA diameter and mean PA pressure ( r = 0.23, p < 0.001). Male sex, higher age, shorter 6MWD and higher NT-proBNP level were independently associated with mortality, but PA diameter was not.

Conclusion
The prognosis of PAH and CTEPH is still poor. Known predictors of survival were confirmed, but PA diameter at diagnosis was not associated with survival in PAH or CTEPH patients.
Cities and countries in the global scientist mobility network
Authors: Verginer Luca , Riccaboni Massimo 
Published: July 2020

AbstractGlobal mobility and migration of scientists is an important modern phenomenon with economic and political implications. As scientists become ever more footloose it is important to identify general patterns and regularities at a global scale and how it impacts a country’s scientific output. The analysis of mobility and brain circulation patterns at global scale remains challenging, due to difficulties in obtaining individual level mobility data. In this work we trace intercity and international mobility through bibliographic records. We reconstruct the intercity and international mobility network of 3.7 million life scientists moving between 5 thousand cities and 189 Countries. In this exploratory analysis we offer evidence that international scientist mobility is marked by national borders and show that international mobility boosts the scientific output of selected countries.
Downregulation of cAMP-Dependent Protein Kinase Inhibitor-b Promotes Preeclampsia by Decreasing Phosphorylated Akt
Authors: Liu Chunfeng , Wang Hao , Yang Mo , Liang Yiheng , Jiang Li , Sun Siman , Fan Shangrong 
Published: July 2020

AbstractPreeclampsia is a multi-system disease that is unique to human pregnancy. Impaired extravillous trophoblast migration and invasion accompanied by poor spiral vascular remodeling is thought to be the initial reason. This study investigated cAMP-dependent protein kinase inhibitor-b(PKIB) expression in placentas and its involvement in the pathogenesis of PE. We used immunohistochemistry and western blotting to calculate PKIB levels in the placentas. Then we knocked down PKIB by siRNA and used real-time cell analysis to assess the invasion and migration ability of trophoblasts. Tube formation assay and spheroid sprouting assay were utilized to identify the ability to form vessels of trophoblasts. At last, western blotting was used to demonstrate the level of phosphorylated Akt, as well as downstream-related genes of Akt signaling pathway in trophoblasts. We first found that PKIB expression level was lower in the PE placentas than in the normal placentas. In addition, we found that downregulation of PKIB can inhibit the migration, invasion, and the ability to form vessels of HTR8/SVneo cells. Downregulation of PKIB leaded to a decrease in phosphorylated Akt, as well as downstream proteins such as matrix metalloproteinase 2, matrix metalloproteinase 9, and glycogen synthase kinase 3β, which are related to migration and invasion. Our study revealed that the downregulation of PKIB expression resulted in decreased migration, invasion, and vessel formation ability by regulating Akt signaling pathway in placental trophoblasts in PE.
Na2CO3
-Responsive Photosynthetic and ROS Scavenging Mechanisms in Chloroplasts of Alkaligrass Revealed by Phosphoproteomics
Authors: Suo Jinwei , Zhang Heng , Zhao Qi , Zhang Nan , Zhang Yongxue , Li Ying , Song Baohua , Yu Juanjuan , Cao Jianguo , Wang Tai , Luo Ji , Guo Lihai , Ma Jun , Zhang Xumin , She Yimin , Peng Lianwei , Ma Weimin , Guo Siyi , Miao Yuchen , Chen Sixue , Qin Zhi , Dai Shaojun 
Published: July 2020

Abstract
Alkali-salinity exerts severe osmotic, ionic, and high-pH stresses to plants. To understand the alkali-salinity responsive mechanisms underlying photosynthetic modulation and reactive oxygen species (ROS) homeostasis, physiological and diverse quantitative proteomics analyses of alkaligrass (Puccinellia tenuiflora) under Na2CO3 stress were conducted. In addition, Western blot, real-time PCR, and transgenic techniques were applied to validate the proteomic results and test the functions of the Na2CO3-responsive proteins. A total of 104 and 102 Na2CO3-responsive proteins were identified in leaves and chloroplasts, respectively. In addition, 84 Na2CO3-responsive phosphoproteins were identified, including 56 new phosphorylation sites in 56 phosphoproteins from chloroplasts, which are crucial for the regulation of photosynthesis, ion transport, signal transduction, and energy homeostasis. A full-length PtFBA encoding an alkaligrass chloroplastic fructose-bisphosphate aldolase (FBA) was overexpressed in wild-type cells of cyanobacterium Synechocystis sp. Strain PCC 6803, leading to enhanced Na2CO3 tolerance. All these results indicate that thermal dissipation, state transition, cyclic electron transport, photorespiration, repair of photosystem (PS) II, PSI activity, and ROS homeostasis were altered in response to Na2CO3 stress, which help to improve our understanding of the Na2CO3-responsive mechanisms in halophytes.
Local Environmental Policy in a Federal System: An Overview
Authors: Segerson Kathleen 
Published: July 2020

AbstractA number of issues arise when considering the positive and normative implications of local environmental policy making. This paper provides an overview of some of the issues and implications. These vary depending on whether local jurisdictions are charged with determining the stringency of policies or instead stringency is determined at a higher level of government and the local role focuses on implementation and the design of cost-effective measures for achieving the required goals. Key issues include both physical and economic spillovers across jurisdictions, and the extent to which stringency can be differentiated based on local conditions or preferences.
Steady-state analysis of load-balancing algorithms in the sub-Halfin–Whitt regime
Authors: Liu Xin , Ying Lei 
Published: July 2020

AbstractWe study a class of load-balancing algorithms for many-server systems (N servers). Each server has a buffer of size $b-1$ with $b=O(\sqrt{\log N})$, i.e. a server can have at most one job in service and $b-1$ jobs queued. We focus on the steady-state performance of load-balancing algorithms in the heavy traffic regime such that the load of the system is $\lambda = 1 - \gamma N^{-\alpha}$ for $0<\alpha<0.5$ and $\gamma > 0,$ which we call the sub-Halfin–Whitt regime ($\alpha=0.5$ is the so-called Halfin–Whitt regime). We establish a sufficient condition under which the probability that an incoming job is routed to an idle server is 1 asymptotically (as $N \to \infty$) at steady state. The class of load-balancing algorithms that satisfy the condition includes join-the-shortest-queue, idle-one-first, join-the-idle-queue, and power-of-d-choices with $d\geq \frac{r}{\gamma}N^\alpha\log N$ (r a positive integer). The proof of the main result is based on the framework of Stein’s method. A key contribution is to use a simple generator approximation based on state space collapse.
ARCog: An Aerial Robotics Cognitive Architecture
Authors: Pinto Milena F. , Honório Leonardo M. , Marcato Andre L. M. , Dantas Mario A. R. , Melo Aurelio G. , Capretz Miriam , Urdiales Cristina 
Published: July 2020

SUMMARYEfficient algorithm integration is a key issue in aerial robotics. However, only a few integration solutions rely on a cognitive approach. Cognitive approaches break down complex problems into independent units that may deal with progressively lower-level data interfaces, all the way down to sensors and actuators. A cognitive architecture defines information flow among units to produce emergent intelligent behavior. Despite the improvements in autonomous decision-making, several key issues remain open. One of these issues is the selection, coordination, and decision-making related to the several specialized tasks required for fulfilling mission objectives. This work addresses decision-making for the cognitive unmanned-aerial-vehicle architecture coined as ARCog. The proposed architecture lays the groundwork for the development of a software platform aligned with the requirements of the state-of-the-art technology in the field. The system is designed to provide high-level decision-making. Experiments prove that ARCog works correctly in its target scenario.
Improving social–emotional competence in internationally adopted children with the Attachment and Biobehavioral Catch-up intervention
Authors: Lind Teresa , Lee Raby K. , Goldstein Alison , Bernard Kristin , Caron EB , Yarger Heather A. , Wallin Allison , Dozier Mary 
Published: July 2020

AbstractChildren adopted internationally experience adverse conditions prior to adoption, placing them at risk for problematic social–emotional development. The Attachment and Biobehavioral Catch-up (ABC) intervention was designed to help internationally adoptive parents behave in ways that promote young children's social–emotional competence. Participants included 131 parent–child dyads randomly assigned to receive either ABC (n = 65) or a control intervention (n = 66). In addition, 48 low-risk biologically related parent–child dyads were included as a comparison group. At follow-up assessments conducted when children were 24 to 36 months old, internationally adopted children who received the ABC intervention had higher levels of parent-reported social–emotional competence than children who received a control intervention. In addition, observational assessments conducted when children were 48 and 60 months of age showed that internationally adopted children who received ABC demonstrated higher social–emotional competence than children who received a control intervention. Adopted children who received the control intervention, but not the ABC intervention, displayed more difficulties with social–emotional competence than low-risk children. Finally, postintervention parent sensitivity mediated the effect of ABC on observed child social–emotional competence in parent interactions, controlling for preintervention parent sensitivity. These results demonstrate the efficacy of a parenting-focused intervention in enhancing social–emotional competence among children adopted internationally.
Nutrient pattern of unsaturated fatty acids and vitamin E increase resting metabolic rate of overweight and obese women
Authors: Yarizadeh Habib , Setayesh Leila , Roberts Caroline , Yekaninejad Mir Saeed , Mirzaei Khadijeh 
Published: July 2020

Abstract. Objectives: Obesity plays an important role in the development of chronic diseases including cardiovascular disease and diabetes. A low resting metabolic rate (RMR) for a given body size and composition is a risk factor for obesity, however, there is limited evidence available regarding the association of nutrient patterns and RMR. The aim of this study was to determine the association of nutrient patterns and RMR in overweight and obese women. Study design: This cross-sectional study was conducted on 360 women who were overweight or obese. Method: Dietary intake was assessed using a semi-quantitative standard food frequency questionnaire (FFQ). Nutrient patterns were also extracted by principal components analysis (PCA). All participants were evaluated for their body composition, RMR, and blood parameters. Result: Three nutrient patterns explaining 64% of the variance in dietary nutrients consumption were identified as B-complex-mineral, antioxidant, and unsaturated fatty acid and vitamin E (USFA-vit E) respectively. Participants were categorized into two groups based on the nutrient patterns. High scores of USFA-vit E pattern was significantly associated with the increase of RMR (β = 0.13, 95% CI = 0.79 to 68.16, p = 0.04). No significant associations were found among B-complex-mineral pattern (β = −0.00, 95% CI = −49.67 to 46.03, p = 0.94) and antioxidant pattern (β = 0.03, 95% CI −41.42 to 22.59, p = 0.56) with RMR. Conclusion: Our results suggested that the “USFA-vit E” pattern (such as PUFA, oleic, linoleic, vit.E, α-tocopherol and EPA) was associated with increased RMR.
Vitamin A does not influence mRNA expression of hormone hepcidin but other biomarkers of iron homeostasis in young male Wistar rats
Authors: Restrepo-Gallego Mauricio , Díaz Luis E. 
Published: July 2020

Abstract. The effects of an adequate supply of vitamin A and iron, in comparison with diets low or absent in vitamin A and low in iron, on the mRNA expression of some biomarkers of iron homeostasis as hepcidin ( Hamp), transferrin receptor-1 ( Tfrc), iron regulatory protein-2 ( Ireb2) and ferritin ( Fth1) in rats were investigated. 35 male Wistar rats were randomly divided into 5 dietary groups: control, sufficient in iron and insufficient in vitamin A (FesvAi), sufficient in iron and depleted in vitamin A (FesvAd), insufficient in iron and sufficient in vitamin A (FeivAs) and insufficient in both iron and vitamin A (FeivAi). After 6 weeks rats showed no significant effects of variations in vitamin A on the expression of Hamp relative to the control group (FesvAi: 1.37-fold; FesvAd: 1.22-fold); however, iron deficiency showed significant reduction on it relative to the control group (FeivAs: 71.4-fold, P = 0.0004; FeivAi: 16.1-fold, P = 0.0008). Vitamin A deficiency (FesvAd) affects expression of Fth1 independent of low dietary iron in spleen (0.29-fold, P = 0.002) and duodenum (5.15-fold, P = 0.02). Variations of dietary iron and vitamin A showed significant effects relative to the control group for expression of Tfrc in spleen (FesvAd: 0.18-fold, P = 0.01; FeivAs: 0.24-fold, P < 0.0001; FeivAi: 0.42-fold, P = 0.014), Ireb2 in spleen (FeivAs: 3.7-fold, P < 0.0001; FeivAi: 2.9-fold, P < 0.0001) and Ireb2 in duodenum (FeivAs: 2.68-fold, P = 0.012; FeivAi: 2.60-fold, P = 0.014). These results show that vitamin A and iron must be supplied together to regulate some of the main biomarkers of iron metabolism as a strategy to reduce prevalence of iron deficiency anemia.