bluuebunny/crossref_metadata_2025_split huggingface dataset:
Skeletal Stem Cells: A Basis for Orthopaedic Pathology and Tissue Repair
Authors: Cong Ting , Morse Kyle W. , Sosa Branden R. , Lane Joseph M. , Rodeo Scott A. , Greenblatt Matthew B. 
Published: December 2024

➢ Skeletal stem cells (SSCs) continually replenish mature cell populations to support skeletal homeostasis.➢ SSCs repopulate by self-renewal, have multilineage potential, and are long-lived in vivo.➢ SSCs express specific combinations of cell surface markers that reflect their lineage identity.➢ SSCs adapt to their anatomic environment to support regional differences in skeletal behavior and pathology.
Failure Modes and Fault Morphology
Authors: Cawood Adam J. , Ferrill David A. , Smart Kevin J. 
Published: December 2024

Abstract
Fault failure modes determine the geometric characteristics of faults and fault zones during their formation and early development. These geometric properties, in turn, govern a wide range of fault processes and behaviors, such as reactivation potential, fault propagation, and growth, and the hydraulic properties of faults and fault zones. Here, we use field data and close-range digital photogrammetry to characterize, in detail, the surface morphology of three normal faults with cm-scale displacements in mechanically layered carbonates of the Cretaceous Glen Rose Formation at Canyon Lake Gorge, Comal County, Texas. Analyses demonstrate complex fault surface geometries, a broad spectrum of slip tendency (Ts) and dilation tendency (Td), and variable failure behavior. We show that (i) fault patches coated with coarse calcite cement tend to have moderate to high dips, low to high Ts, and high to very high Td; (ii) slickensided fault patches exhibit low to moderate dips, moderate to very high Ts, and moderate to high Td; and (iii) slickolite patches exhibit low dips, moderate Ts, and low to moderate Td. Calcite-coated patches are interpreted to record hybrid extension-shear failure, whereas slickensided and slickolite patches record shear and compactional shear failure, respectively. Substantial variability in both Ts and Td across the exposed fault surfaces reflects complex fault morphology that is not easily measured using traditional field techniques but is captured by our photogrammetry data. We document complex fault geometries, with kinematic (displacement) compatibility indicating the various failure modes were active coevally during fault slip. This finding is in direct contrast with the often-assumed concept of faults forming by shear failure on surfaces oriented 30° to σ1. Distinct failure behaviors are consistent with patchworks of volume neutral, volume gain, and volume loss zones along the fault surfaces, indicating that the characterized faults likely represent dual conduit-seal systems for fluid flow.
PROYECTOS INNOVADORES EN EL SECTOR AZUL: IMPULSANDO LA SOSTENIBILIDAD Y EL DESARROLLO ECONÓMICO DE LOS RECURSOS MARINOS
Authors: Vidal Julián Lucía , Paradís Leopori Iris 
Published: December 2024

The Spanish region and the Mediterranean basin are positioned as a globally recognised biodiversity hotspot, hosting more than half of Europe’s catalogued species. However, this biological wealth faces serious threats such as terrestrial and marine pollution, habitat destruction and overfishing. In response to this scenario, significant efforts have been undertaken to restructure economic sectors towards sustainable and environmentally friendly models, with the blue sector being particularly prominent. This sector advocates the sustainable exploitation of seas and oceans, facing challenges such as generational change. Faced with this problem, there is a need for innovative initiatives that integrate education and environmental sustainability, using methodologies that attract new generations to professions in the blue sector. In this context, the Centro de Formación Folgado has led several initiatives at European, national and local level, with the aim of addressing the lack of generational change and promoting the sustainable management of marine resources. Its European projects include Blue Careers for a Sustainable Blue Economy (BOUTCAR), an educational alliance to develop training pathways in the blue sector, and Let’s Form Marine Shelters (FOMSHE), focused on the recovery of the seahorse in the Mediterranean. At the national level, the Emprende Impact project promoted a sustainable entrepreneurship programme aimed at vocational training students. At the local level, the Green Posidonia project has worked on the creation of a pilot plant for the cultivation of Posidonia oceanica and its repopulation, together with educational workshops, while Green Urban Changemakers promoted a more sustainable urban development in the city of Valencia. In addition, the Centre collaborates in other European projects such as BlueCircle, which identifies opportunities within the blue sector, and Let’s Talk Under The Sea (TAUTS), an initiative to promote ocean culture and raise awareness of the effects of underwater noise on marine wildlife. These initiatives reflect a strong commitment to sustainability and innovative education, consolidating the Centro de Formación Folgado as a benchmark in the transformation towards a more sustainable and attractive blue sector for new generations.
Industrial policy and the State of development: to actualization of the notion
Authors: Volynskii A. I. 
Published: December 2024

Objective: to analyze the trajectories of industrial policy effective implementation by determining the relevance of key elements of the “development state” model in modern international realities. Methods: monographic, historical, abstract-logical, comparative methods. Results: the characteristics of the “development states” concept described on the example of some Asian countries allowed their governments to carry out industrial modernization of national economies in a short time and switch to the sustainable economic development trajectory. For many years, the “development state” has been perceived by researchers as part of history. This was determined by the consensus on the existing boundaries of state intervention in the economy. In recent years, the interest of governments in industrial policy has been growing. The implementation of measures withinthe industrial policy gives rise to new challenges to public administration, probably similar to those that the development states have gone through. The author shows that the available formulations of the qualitative characteristics inherent both in the “development state” concept and in some Asian countries in a certain period of their development are significant for the modern theory of public administration in the context of industrial policy measures. Scientific novelty: it consists in understanding the concept of the “development state” in the modern context. Practical significance: the research provisions and conclusions can be used in the future studies of the economic theory influence on socio-political discourses and political decisions.
Sector trends of total factor productivity: where is the growth potential?
Authors: Kadochnikova E. I. , Bagautdinova N. G. , Khomidov S. O. 
Published: December 2024

Objective: to identify industry trends in aggregate factor productivity, labor productivity and capital productivity in economic sectors. The hypotheses are: there is a continuing slowdown in aggregate factor productivity in the Russian economy sectors; there is a gap in aggregate factor productivity in various complexes of industries. Methods: Cobb–Douglas production function, multiple regression, Domar aggregation, Gini coefficient, graphical visualization. Results: the study revealed a more efficient use of labor resources in contrast to capital, the latter being accumulated everywhere. The highest increase in labor productivity was noted in financial and insurance activities, manufacturing industries, professional, scientific and technical activities. There is a cyclical dynamics of aggregate factor productivity, its most stable growth and a positive cumulative technological shift marked from 2017 until 2021. They are observed in the manufacturing and investment complexes of the Russian economy (financial and insurance activities), and in agriculture.A decrease in total factor productivity was found in the mining industry, transportation and storage, hotels and catering, construction, education, and healthcare. Scientific novelty: it consists in a change in the total factor productivity and the total technological shift in the context of sectors and complexes of sectors of the Russian economy from 2011 to 2021. Practical significance: the study results can be used for the policy of stimulating internal sources of economic growth, to improve sectoral recommendations of innovation policy.
Institute of bankruptcy in the Russian Federation: establishment and ways of development of the legal provision
Authors: Belousov A. L. 
Published: December 2024

Objective: to study the issues of regulation of bankruptcy relations and to determine the ways of further development of the legal field in this sphere. Methods: historical method, logical and structural analysis, system-functional approach, formal-legal method. Results: the article considers formation of the bankruptcy institute in the Russian Federation. In addition, the modern state of legal support in this field is analyzed. The peculiarities of the Russian model of bankruptcy regulation are outlined. Further, the author emphasizes the current problems in the regulation of bankruptcy relations in the Russian Federation. In particular,the author notes that the procedures aimed at restoring the solvency of debtors are not in demand in practice. The study also emphasizes the problem of a relatively low percentage of satisfied creditors’ claims as a result of bankruptcy procedures. An assessment is given of the current project of changing the legal field in this area proposed by the legislator. The ways of further development of bankruptcy legislation are defined. Scientific novelty: consists in the complex nature of the study of bankruptcy relations. In particular, the research provides a new development of theoretical provisions, as well as practical recommendations to improve legal regulation and increase the effectiveness of the bankruptcy institute. It is established that today there is a smooth transition from the pro-debtor model of bankruptcy relations, which was previously dominating, to a more balanced mechanisms of insolvency regulation from the viewpoint of creditor and debtor interests. It is also argued that it is necessary to abandon the financial rehabilitation and external management procedures, which actually do not work in practice, and to replace them with a single rehabilitation procedure aimed at restoring the debtor’s solvency. Practical significance: a certain theoretical basis was formed, which is necessary both for researching the essence of the bankruptcy institute in the Russian Federation and for developing proposals to adjust regulatory policy in this area in the future.
Profiling of pathogenic variants in Japanese patients with sarcoglycanopathy
Authors: Shimazaki Rui , Saito Yoshihiko , Awaya Tomonari , Minami Narihiro , Kurosawa Ryo , Hosokawa Motoyasu , Ohara Hiroaki , Hayashi Shinichiro , Takeuchi Akihide , Hagiwara Masatoshi , Hayashi Yukiko K , Noguchi Satoru , Nishino Ichizo 
Published: December 2024

Abstract

Background
Sarcoglycanopathies (SGPs) are limb-girdle muscular dystrophies (LGMDs) that can be classified into four types, LGMDR3, LGMDR4, LGMDR5, and LGMDR6, caused by mutations in the genes, SGCA, SGCB, SGCG, and SGCD, respectively. SGPs are relatively rare in Japan. This study aims to profile the genetic variants that cause SGPs in Japanese patients.
Methods
Clinical course and pathological findings were retrospectively reviewed in Japanese patients with SGP. Genetic analyses were performed using a combination of targeted resequencing with a hereditary muscle disease panel, whole genome sequencing, multiplex ligation-dependent probe amplification, and long-read sequencing. The structures of transcripts with aberrant splicing were also determined by RT-PCR, RNA-seq, and in silico prediction.
Results
We identified biallelic variants in SGC genes in 53 families, including three families with LGMDR6, which had not been identified in Japan so far. SGCA was the most common causative gene, accounting for 56% of cases, followed by SGCG, SGCB, and SGCD, at 17%, 21%, and 6%, respectively. Missense variants in SGCA were very frequent at 78.3%, while they were relatively rare in SGCB, SGCG, and SGCD at 11.1%, 18.2%, and 16.6%, respectively. We also analyzed the haplotypes of alleles carrying three variants found in multiple cases: c.229C > T in SGCA, c.325C > T in SGCB, and exon 6 deletion in SGCG; two distinct haplotypes were found for c.229C > T in SGCA, while each of the latter two variants was on single haplotypes.
Conclusions
We present genetic profiles of Japanese patients with SGPs. Haplotype analysis indicated common ancestors of frequent variants. Our findings will support genetic diagnosis and gene therapy.
Proline isomerization is a key modulator of the bacterial IsdB/hemoglobin interaction: an Atomic Force Spectroscopy study
Authors: Pancrazi Francesca , Bei Omar , Tocco Francesco Lavecchia , Marchetti Marialaura , Campanini Barbara , Cannistraro Salvatore , Bettati Stefano , Bizzarri Anna Rita 
Published: December 2024

Abstract

Iron surface determinant B (IsdB), a Staphylococcus aureus (SA) surface protein involved in both heme iron acquisition from host hemoglobin (Hb) and bacterial adhesion, is a proven virulence factor that can be targeted for the design of antibacterial molecules or vaccines. Recent single-molecule experiments on IsdB interaction with cell adhesion factors revealed an increase of the complex lifetime upon applying a stronger force (catch bond); this was suggested to favor host invasion under shear stress. An increased bond strength under mechanical stress was also detected by Atomic Force Spectroscopy (AFS) for the interaction between IsdB and Hb. Structural information on the underlying molecular mechanisms at the basis of this behaviour in IsdB-based complexes is missing. Here, we show that the single point mutation of Pro173 in the IsdB domain responsible for Hb binding, which weakens the IsdB:Hb interaction without hampering heme extraction, totally abolishes the previously observed behavior. Remarkably, Pro173 does not directly interacts with Hb, but undergoes cis-trans isomerization upon IsdB:Hb complex formation, coupled to folding-upon binding of the corresponding protein loop. Our results suggest that these events might represent the molecular basis for the stress-dependence of bond strength observed for wild type IsdB, shedding light on the mechanisms that govern the capability of SA to infect host cells.
A robust and durable superhydrophobic cotton fabric with excellent self-cleaning performance for oil/water separation
Authors: Zhou Zixing , Du Xiaosheng , Tang Jiayi , Du Junhui , Deng Sha , Wang Haibo 
Published: December 2024

Abstract

Graphical abstract
Abstract: Superhydrophobic cotton fabric is regarded as an accessible and efficient technology for oily wastewater cleanup because of high porosity, switch wettability, and low cost. However, the existing superhydrophobic fabrics cannot maintain durable superhydrophobicity during practical application due to poor action force between hydrophobic substance and fabric. Herein, a robust and durable fluorine-free superhydrophobic cotton fabric was successfully fabricated through a facile two-step modification process. Firstly, amino-functionalized SiO2 nanoparticles were chemically bonded to the cotton fabric surface, creating a rough structure with peaks and valleys. Subsequently, the surface was impregnated with a layer of hydrophobic polydimethylsiloxane (PDMS) for surface modification, resulting in a superhydrophobic surface effective for the separation of oil-water mixtures. The as-prepared superhydrophobic cotton fabric (PDMS-SiO2@cot) presented superhydrophobic property with water contact angle reached 156.7°. Meanwhile, the prepared PDMS-SiO2@cot can effectively separated various oil-water mixtures with high separation efficiency (98.2%-99.4%). Furthermore, the superhydrophobic cotton fabric demonstrated remarkable robustness by maintaining its hydrophobic characteristics after being subjected to a series of durability tests, including immersing into various solutions (acidic solution, alkaline solution, and organic solvents), exposuring ultrasonication, and experiencing mechanical stress (scraping, adhesive tape peeling, and sandpaper abrasion). In conclusion, the as-prepared superhydrophobic cotton fabric PDMS-SiO2@cot with excellent mechanical stability, chemical resistance, and self-cleaning properties show considerable potential for oily water remediation.
Biodegradable Polymeric Membranes Via Additive Manufacturing for Application in Water Treatment
Authors: Fortes Allef Gabriel da Silva , de Abreu Iago Rodrigues , Júnior Renato de Sousa Nascimento , Sampaio Arthur Antonio Sousa , Leitão Luigi Veloso , Reis Ana Luisa Teixeira , Silva Lauriene Gonçalves da Luz , de Morais Ana Carolina Lemos , Alves Tatianny Soares , Barbosa Renata , Folkersman Rudy 
Published: December 2024

Abstract

3D printing has found applications across various sectors, including water treatment, where the incorporation of novel materials enhances sustainability and imparts specific functional properties. This study focused on the production of polymeric filaments for Fused Deposition Modeling (FDM) 3D printing, utilizing a PLA/PBAT blend infused with activated carbon and magnesium oxide, with concentrations up to 6 parts per hundred resin (PHR), for use in water treatment membranes. The distribution, composition, and morphology of the particles were assessed using Scanning Electron Microscopy (SEM) and Energy Dispersive Spectroscopy (EDS). Alterations in physical properties, including water absorption and contact angle, were observed in comparison to the pure commercial blend. An adsorption efficiency exceeding 60% for methylene blue was achieved, as confirmed by SEM analysis of the membranes. Furthermore, the filaments demonstrated suitability for the production of high-quality water treatment membranes, as evidenced by SEM and Optical Microscopy (OM) analysis.
Mapping water quality parameters using Landsat 8 multispectral imagery, case study of Rwandan water bodies
Authors: Mukarugwiro Jeanne d'Arc , Newete Solomon , Abutaleb Khaled , Nsanganwimana Florien , Adam Elhadi , Parrini Francesca , Byrne Marcus 
Published: December 2024

Abstract

Water plays significant role in an aquatic ecosystem, and it displays its own biotic and abiotic characteristics that indicate the status of the ecosystem. Thus, it is crucial to assess and monitor the quality of water to ensure that it remains functional. Field-based methods are used to assess and quantify key water quality indicators such as temperature, nitrogen, phosphorus, and turbidity levels. However, such methods are labour intensive, expensive, and therefore not ideal to monitor broad scale spatial and temporal variations of biotic and abiotic characteristics of water. On the other hand, remote sensing can offer information on surface water quality parameters that are not readily available when using field surveys, making it possible to continuously monitor, and quantify specific water quality parameters. The main aim of this study was to determine the spatial distribution of temperature, nitrogen, phosphorus, and turbidity in several Rwandan water bodies. Images from Landsat 8 acquired in August and November were processed according to individual band, band rationing as well as band combination. Maps were produced according to the correlation between the field based measured water parameters and the reflectance values of the Landsat 8 image. Results showed that Rwandan water bodies are more turbid and eutrophied; and warmer in the wet season compared to the dry season. These results can help Rwandan water resource management to create a geographically located database for future water surface in different water bodies.
Academic Resource Preferences for Medical Students Pursuing Orthopaedic Surgery
Authors: Malhotra Arjun 
Published: December 2024

Abstract

PURPOSE: This study explores the preferences of academic materials favored by medical students pursuing orthopaedic surgery. It aims to assess how these resources are perceived in terms of their utility in both pre-clinical education and clinical rotations. Additionally, the study explores the potential significance of visual mnemonics, a resource currently underrepresented in orthopaedic education.
METHODS: Deidentified electronic surveys, using the web-based platform SurveyMonkey, were distributed via national medical student orthopedic societies and medical student orthopedic interest groups. The surveys included multiple choice questions prompting respondents to rate their perceived usefulness of various educational resources, and their responses were analyzed using non-parametric statistical methods.
RESULTS: Significant variations in resource preferences were identified across subjects. A consistent consensus was held that board reviews, question banks, and flashcards have greater utility compared to textbooks and lectures for pre-clinical subjects. A similar pattern emerged for clinical rotation resources with direct patient care, review resources, question banks, and flashcards being favored over conventional instructional methods. Visual mnemonics demonstrated efficacy in subjects demanding memorization-intensive efforts and most respondents expressed their belief that visual mnemonics would be useful in their orthopaedic studies.
CONCLUSION: The transition from conventional lecture-based instruction to dynamic, interactive learning approaches is a hallmark of modern medical education. This research provides strong evidence that medical students aspiring to become orthopaedic surgeons have a pronounced preference for active learning resources. These insights offer valuable guidance for refining educational strategies tailored to orthopaedic surgery candidates, potentially bolstering their success in securing positions in this competitive field.
RO8191, a new compound for initiating embryo implantation in mice
Authors: Shu Junlan , Terakawa Jumpei , Osuka Satoko , Muraoka Ayako , Ruan Jiali , Iida Atsuo , Ito Junya , Hondo Eiichi 
Published: December 2024

Abstract

During early pregnancy in mice, leukemia inhibitory factor (LIF) regulates embryo implantation by activating the JAK/STAT3 signaling pathway. The STAT3 pathway has been recognized to play a critical role in embryo implantation. However, it is not clear whether STAT3 activation itself can cause induction of embryo implantation. In this study, the effects of RO8191, a potential STAT3 activator, on embryo implantation were investigated through a series of studies with different mouse models. We found that RO8191 can induce embryo implantation by activating the STAT3 pathway in delayed implantation mice. Furthermore, RO8191 can initiate decidualization, which is essential for embryo implantation, even in uterine epithelial-specific Stat3, Gp130, or Lifr conditional knockout (cKO) mice that exihbits infertility due to embryo implantation failure. Histomorphological observations revealed successful embryo implantation and embryonic development in Lifr cKO mice. Increased epithelial detachment and vascularization were observed in Stat3 cKO mice, and excessive inflammatory response and embryo death were observed in Gp130cKO mice. These results suggest that STAT3, Gp130 and LIFR each play a distinct role in embryo implantation and development. Although the specific mechanisms of RO8191 are not fully understood, this study providedinsights to support the application of RO8191 in treating recurent implantation failure.