bluuebunny/crossref_metadata_2025_split huggingface dataset:
The retrospective analysis results of the endometrial tissue pathological conditions development
Authors: Artyomenko V. V. , Chumak Z. V. , Shapoval M. V. 
Published: December 2020

Hyperplastic processes of endometrium are one of the most common pathologies of the uterus mucosa, an interest in its study is due to an increase in the frequency of occurrence, the ability to both self-healing and malignancy.Purpose of the study: to investigate the detection rate of endometrial proliferative changes depending on the age of woman.Materials and methods. A retrospective medical documentation analysis of the Department of Pathology was conducted. 2196 pathologic findings of endometrial tissue samples were investigated. 1404 specimen were hyperplastic states, 688 were endometrial polyps, and 104 others were endometrial states after total or subtotal uterine removal after surgery. Histological conditions were distributed according to patients’ age categories. Results of the study were processed statistically using variation statistics with Student's criterion, using standard computer systems.Results. The analysis shows an increase in frequency of endometrial proliferative changes in perimenopausal patients on the background of endometrial pathological changes detection in all age categories. Atypical forms of simple and complex hyperplasia of the endometrium can be traced in all age categories, with a maximum frequency of manifestation in similar age-related periods – 41–45 years and 46–50 years. Morphological signs of endometrial tissue malignancy were first established in the age group of 46–50 years, which coincides with the age of the onset of menopause in the Odesa region, with subsequent relative increase in the frequency and aggressiveness of the process with age. These age groups focus doctors to be more careful about pathological manifestations.Conclusion. As a result of retrospective analysis of histopathological examinations it was found that the main factor in detecting pathological conditions of the endometrium is a woman's age of perimenopausal period, which can be considered as an early marker of diagnosis, leading to treatment prospects and general therapeutic tactics, for the future diagnostics and detection of others immunohistochemical and molecular genetic markers in women with hyperplastic processes in endometrial tissue.
Teori Batas Kewarisan Muhammad Syahrur dan Relevansinya dengan Keadilan Sosial
Authors: Asmara Musda , Kurniawan Rahadian , Agustian Linda 
Published: December 2020

The provision of inheritance between men and women with the current ratio of 2: 1 is considered not to provide an equal share and has not yet reflected the value of justice. This paper intends to study the views of Muhammad Syahrur related to the 2: 1 concept in faraidh science. This research is a qualitative study by presenting data descriptively. The results of this study indicate that the concept of the limit theory offered by Muhammad Syahrur is a proportional division between sons and daughters, where sons get 2 portions as the maximum limit, not more but maybe less. While the daughters get one portion as the minimum limit and therefore, it is still possible to get more but cannot be less. In certain conditions, daughters and sons can get an equal share of the inheritance. The theory offered by Muhammad Syahrur is relevant to the values of social justice, especially if women provide for family expenses. In this condition, women's rights are increased by not exceeding the corridors or limitations of God's law.Ketentuan bagian waris antara laki-laki dan perempuan dengan perbandingan 2:1 untuk masa sekarang dianggap belum memberikan bagian yang setara dan belum mencerminkan nilai keadilan. Tulisan ini bermaksud mengkaji pandangan satu tokoh terkait konsep 2:1 dalam ilmu faraidh, yaitu Muhammad Syahrur. Penelitian ini merupakan penelitian kualitatif dengan menyajikan data secara deskriptif. Hasil penelitian ini menunjukkan bahwa konsep teori batas yang ditawarkan Muhammad Syahrur adalah pembagian yang proporsional antara laki-laki dan perempuan, yaitu bahwa anak laki-laki mendapat bagian dua sebagai batas maksimal, tidak boleh lebih namun boleh kurang. Sementara anak perempuan mendapat bagian satu adalah batas minimal dan karena itu masih mungkin mendapatkan lebih dari satu namun tidak boleh kurang. Teori ini didasarkan pada metode teknik analisis, analisa matematis, teori himpunan, konsep variabel pengikut dan variabel pengubah sehingga 2:1 tidak selamanya relevan dengan kondisi masing-masing ahli waris. Pada kondisi tertentu perempuan dan laki-laki bisa mendapat bagian harta warisan sebanding atau sama banyak. Teori batas yang ditawarkan oleh Muhammad Syahrur relevan dengan nilai-nilai keadilan sosial, jika perempuan menjadi tulang punggung keluarga. Pada kondisi tersebut hak perempuan bertambah dengan tidak melebihi koridor atau batasan-batasan hukum Allah.Kata Kunci: waris; keadilan sosial; teori batas.
A. Djazuli's Thinking Regarding Ḥifẓu al-Ummah: Dismissing the Entangled Bureaucracy to Commemorate the Era of Society 5.0
Authors: Ahmad Sabarudin , Anggraeni Novita , Pambudi Andrian Kukuh 
Published: December 2020

Abstract: Nations in the world have been preoccupied with new ideas in the form of the society 5.0 era, while this nation is still trying to release the entangled bureaucracy. The government's efforts in reforming the bureaucracy with its various standards have not been able to produce satisfactory results. Therefore, this study seeks to contribute ideas by examining the thoughts of A. Djazuli about ḥifẓu al-ummah on this issue. This research is normative legal research. The analytical method used is the method of content analysis. The results of this study indicate that maqāṣid syarīʽah has been oriented to individual problems, so that they pay less attention to humans in the community. Ḥifẓu al-ummah as the development of maqāṣid syarīʽah places this bureaucratic problem in the category of maqāṣid al-hajiyat. The complicated bureaucracy does not damage human life but is very difficult. The bureaucratic system in Indonesia must be directed at a modern system with artificial intelligence in welcoming the era of 5.0 society.Keywords: bureaucracy; ḥifẓu al-ummah; era of society 5.0Abstrak:Bangsa-bangsa di dunia telah disibukkan dengan gagasan baru berupa era society 5.0, sedangkan bangsa ini masih berusaha melepaskan jeratan birokrasi yang berbelit. Upaya pemerintah dalam mereformasi birokrasi dengan berbagai standarisasinya belum mampu membuahkan hasil yang memuaskan. Oleh karena itu, penelitian ini berusaha memberikan kontribusi pemikiran dengan mengkaji pemikiran A. Djazuli tentang hifz al-ummah terhadap permasalahan ini. Penelitian ini merupakan penelitian hukum normatif. Metode analisis yang digunakan ialah metode analisis isi. Hasil penelitian ini menunjukkan bahwa maqashid syariah selama ini berorientasi pada persoalan individual, sehingga kurang memperhatikan manusia dalam komunitas. Hifz al-ummah sebagai pengembangan dari maqashid syariah menempatkan persoalan birokrasi ini dalam kategori maqashid al-hajiyat. Birokrasi yang berbelit tidak sampai merusak kehidupan manusia tetapi sangat menyulitkan. Sistem birokrasi di Indonesia harus diarahkan pada sistem modern dengan artificial intellegence dalam menyongsong era society 5.0.Kata Kunci: birokrasi; ḥifẓu al-ummah, era sosial 5.0
Preventing Peterson’s space Hernia Using a Bio Synthetic Mesh
Authors: Skidmore Adam Peter , Aarts Edo O 
Published: December 2020

Abstract
BackgroundInternal hernias occur after Roux-en-Y Gastric Bypass surgery (RYGB) when small bowel herniates into the intermesenteric spaces that have been created. The closure technique used is related to the internal hernia risks outcomes. Using a non-resorbable double layered suture, this risk can be significantly reduced from 8.9 to 2.5% in the first three postoperative years. By closing over a BIO mesh, the risk might be reduced even more.SettingTwo large private hospitals specialized in bariatric surgery.MethodsAll patients receiving a RYGB for (morbid) obesity between 2014 and 2018 were included in this retrospective study. In all patients, the entero-enterostomy (EE) was closed using a double layered non-absorbable suture. In 2014, Peterson’s space was closed exclusively using glue, the years hereafter in a similar fashion as the EE, combined with a piece of glued BIO Mesh.ResultsThe glued RYGB patients showed 25% of patients with an internal hernia (14%) or open Peterson’s space compared to 0.5% of patients (p<0.001) who had a combined sutured and BIO Mesh Closure of their Peterson’s space defect. Although this was an ideal technique for Peterson’s space, it led to 1% of entero-enterostomy kinking due to the firm adhesion formation.ConclusionGluing the intermesenteric spaces is not beneficial but placing a BIO Mesh in Peterson’s space is a promising new technique to induce local adhesions. It is above all safe, effective and led to an almost complete reduction of Peterson’s internal herniations. In the future, a randomized controlled trial comparing this technique to a double layered, non-absorbable suture should give more insights into which is the optimal closure technique.
Reablement through time and space: A scoping review of how the concept of ‘reablement’ for older people has been defined and operationalised
Authors: Clotworthy Amy , Kusumastuti Sasmita , Westendorp Rudi GJ 
Published: December 2020

Abstract
Background: While the field of rehabilitation has determined a common definition of professional practice, legislators and healthcare professionals in various Western countries have struggled to reach consensus about how the newer offer of ‘reablement’ should be organised, operationalised, and understood as a health service for older adults. International research indicates that there is confusion, ambiguity, and disagreement about the terminology and the structure of these programmes, and they may not be adequately supporting older people’s self-identified goals. Could an analysis of the concept’s genealogy illuminate how reablement can be more effective and beneficial in theory and in practice?Methods: We conducted a qualitative and quantitative scoping review to determine how reablement has developed through time and space. Eligible articles (n=86) had to focus on any of the defined features of current reablement programmes; there were no restrictions on study designs or publication dates. In articles published from 1947–2019, we identified themes and patterns, commonalities, and differences in how various countries described and defined reablement. We also performed an analysis using computer software to construct and visualise term maps based on significant words extracted from the article abstracts.Results: The fundamental principles of reablement have a long history. However, these programmes have undergone a widespread expansion since the mid-2000s with an intention to reduce costs related to providing long-term care services and in-home assistance to growing older populations. Despite theoretical aspirations to offer person-centred and goal-directed reablement, few countries have been able to implement programmes that adequately promote older people’s goals, social involvement, or participation in their local community in a safe, culturally sensitive and adaptable way. Conclusions: Reablement is meant to support older people in attaining their self-defined goals to be both more physically independent at home and socially involved in their communities. However, until legislators, health professionals, and older people can collectively reach consensus about how person-centred reablement can be more effectively implemented and supported in professional homecare practice, it will be difficult to determine a conceptual description of reablement as a service that is unique, separate, and distinct from standard rehabilitation.
Evaluation of Role of Hyperbilirubinemia as a New Diagnostic Marker of Complicated Appendicitis.
Authors: Bakshi Sabyasachi , Mandal Nilay 
Published: December 2020

Abstract
BACKGROUND:In appendicitis, elevated intra-luminal pressure and ischemic necrosis of mucosa causes tissue gangrene or perforation. This leads to cytotoxin facilitated progressive bacterial invasion or translocation into the hepatic parenchyma through portal system. This phenomenon interferes with the bilirubin excretion into the bile canaliculi.In the present study, establishment of a possible role of hyperbilirubinemia as a marker of gangrenous/perforated appendicitis has been studied.METHODS:After matching the inclusion and exclusion criteria, all cases of clinically diagnosed acute appendicitis were taken for this prospective, single center, observational study. Per-operative diagnosis was confirmed by histopathological examination.RESULTS:Out of 110 subjects of acute appendicitis 41 subjects (37.27%) had hyperbilirubinemia. Out of 35 subjects diagnosed as complicated appendicitis 32 subjects (91.42%) had raised total bilirubin levels, while the remaining 03(8.58%) had normal levels .Among 75 subjects diagnosed as acute simple appendicitis 09 subjects (12%) had raised total bilirubin level, while the remaining 66 subjects (88%) had normal levels .It was Mixed Type Of Hyperbilirubinemia in gangrenous/perforated appendicitis.The sensitivity of Total serum bilirubin in predicting complicated appendicitis was found 91.43% (76.942% to 98.196%), where as the specificity of this test was 88.00% (78.439% to 94.363%). positive predictive value and negative predictive value were 78.03% and 95.65% respectively.Positive likelihood ratio and negative likelihood ratio were found to be 7.619 and 0.097 respectively taking prevalence of Complicated appendicitis be 31.80%.ROC (Receiver Operating Characteristic) curve was obtained which shows optimal criterion at Total Bilirubin Level 1.06 mg/dl where sensitivity was 91.43% and specificity was 97.33% at 95% confidence interval with 31.8% disease prevalence.CONCLUSIONS:This is to conclude that Serum bilirubin level estimation, which is a simple, cheap and easily available laboratory test, can be added to the routine investigations in clinically suspected cases of acute appendicitis for early diagnosis of complications.Trial Registration: Registered with Clinical Trials Registry-India (ICMR-NIMS) with Registration number CTRI/2019/05/018879 Dated 01/05/2019. Trial URL: http://ctri.nic.in/Clinicaltrials/pdf_generate.php?trialid=33113&EncHid=99780.32960&modid=1&compid=19%27,%2733113det%27
­Scaffolding Depth Cues and Perceptual Learning in VR to Train Stereovision: A Proof of Concept Pilot Study
Authors: Godinez Angelica , Martín-González Santiago , Ibarrondo Oliver , Levi Dennis 
Published: December 2020

Abstract
Stereopsis is a valuable feature of human visual perception, which may be impaired or absent in amblyopia and/or strabismus but can be improved through perceptual learning (PL) and videogames. The development of consumer virtual reality (VR) may provide a useful tool for improving stereovision. We report a proof of concept study, especially useful for strabismic patients and/or those with reduced or null stereoacuity. Our novel VR PL strategy is based on a principled approach which included aligning and balancing the perceptual input to the two eyes, dichoptic tasks, exposure to large disparities, scaffolding depth cues and perception for action. We recruited ten adults with normal vision and ten with binocular impairments. Participants played two novel PL games (DartBoard and Halloween) using a VR-HMD. Each game consisted of three depth cue scaffolding conditions, starting with non-binocular and binocular cues to depth and ending with only binocular disparity. All stereo-anomalous participants improved in the game and most (9/10) showed transfer to clinical and psychophysical stereoacuity tests (mean stereoacuity changed from 569 to 296 arc seconds, p<0.0001). Stereo-normal participants also showed in-game improvement, which transferred to psychophysical tests (mean stereoacuity changed from 23 to a ceiling value of 20 arc seconds, p=0.001). We conclude that a VR PL approach based on depth cue scaffolding may provide a useful method for improving stereoacuity, and the in-game performance metrics may provide useful insights into principles for effective treatment of stereo anomalies.
A porcine brain-wide RNA editing landscape
Authors: Huang Jinrong , Lin Lin , Dong Zhanying , Yang Ling , Zheng Tianyu , Gu Weiwang , Zhang Yan , Yin Tailang , Sjöstedt Evelina , Mulder Jan , Uhlen Mathias , Kristiansen Karsten , Bolund Lars , Luo Yonglun 
Published: December 2020

Abstract
Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by ADAR enzymes, is an essential post-transcriptional modiﬁcation. Although hundreds of thousands of RNA editing sites have been reported in mammals, brain-wide analysis of the RNA editing in the mammalian brain remains rare. Here, a genome-wide RNA editing investigation is performed in 119 samples, representing 30 anatomically defined subregions in the pig brain. We identify a total of 682,037 A-to-I RNA editing sites of which 97% are not identified before. Within the pig brain, cerebellum and olfactory bulb are regions with most edited transcripts. The editing level of sites residing in protein-coding regions are similar across brain regions, whereas region-distinct editing is observed in repetitive sequences. Highly edited conserved recoding events in pig and human brain are found in neurotransmitter receptors, demonstrating the evolutionary importance of RNA editing in neurotransmission functions. The porcine brain-wide RNA landscape provides a rich resource to better understand the evolutionally importance of post-transcriptional RNA editing.
Bistatic Scattering Simulations of Circular and Linear Polarizations Over Land Surface for Signals of Opportunity Reflectometry
Authors: Wu Xuerui , Xu Jin , Duan Zheng , Jin Shuanggen , Song Yezhi 
Published: December 2020

Abstract
Signals of Opportunity (SoOp) Reflectometry employs the communication system,GNSS(Global Navigation Satellite System) constellation and other potential Signals of Opportunity as the transmitters .In recent years, it has gained increased interests. Several experiments have been carried out, however it is still in the initial development stage. Theoretical predictions of SoOp Reflectometry for land surface parameters detection, such as soil moisture and vegetation biomass, should be carried out simultaneously. Meanwhile, at present less works are paid attention to the polarization study of the polarizations. The first-order transfer equation modelmodels are employed here and they are developed according to the wave synthesis technique to get the various polarization combinations. Using the two models as analysis tools, we simulate the bistatic scattering at all potential SoOp Reflectometry bands, i.e P-,L-,C- and X-band for circular polarizations and linear polarizations. While the orginal commonly used microwave scattering models are linear polarizations, here we compare the difference. Although the models can simulate bistatic scattering at any incident angles and scattering angles. Four special observation geometry are taken into considerations during the analysis. By using the developed models as tools, the developed models establish the relationship between the land surface parameters(such as soil moisture, soil roughness and vegetation water content, diameters et al.) and bistatic radar cross section. The forward scattering models developed here enables the understanding of the effects of different geophysical parameters and transmitter-receiver observation scenarios on the bisatic scattering at any polarization combinations for any potential SoOP reflectometry bands. Robust retrieval methods for soil moisture and vegetation biomass can benefit from the forward scattering models.
Mediating role of prenatal depression in attachment and maternal-fetal attachment in primigravida in late pregnancy
Authors: Zhang Ling , Wang Lei , Yuan Qiuyu , Huang Cui , Cui Shu , Zhang Kai , Zhou Xiaoqin 
Published: December 2020

Abstract
Background: Prenatal depression and attachment are factors that affect the establishment of an intimate relationship between a mother and fetus. The study explored differences in prenatal depression and maternal-fetal attachment (MFA) scores between different type of attachment as well as the effects of maternal depression scores and attachment dimensions on maternal intimacy with fetus.Methods: The Edinburgh Postnatal Depression Scale (EPDS), Experience of Close Relationship (ECR) scale, Maternal Antenatal Attachment Scale (MAAS) and a general data scale were used to investigate 260 primigravida. Exploratory analysis was performed to analyze the effects of depression score and attachment on MFA.Results: The results showed that pregnant women with insecure attachment exhibited an increased prevalence of prenatal depression, lower total score of MFA and lower MFA quality compared with those women with secure attachment. Explorative analysis showed that depression score mediated the relationship between attachment avoidance and MFA quality.Conclusions: Primigravida who had insecure attachment exhibited an increased prevalence of prenatal depression and lower MFA. Maternal depression and attachment may affect the emotional bond between a mother and fetus. This finding should be taken seriously, and early intervention needs to take personality traits into consideration.
Design and Optimizations of a High-throughput Valve-based Microfluidic Device for Single Cell Compartmentalization and Analysis
Authors: Briones Jonathan , Espulgar Wilfred , Koyama Shohei , Takamatsu Hyota , Tamiya Eiichi , Saito Masato 
Published: December 2020

Abstract
The need for high throughput single cell screening platforms has been increasing with advancements in genomics and proteomics to identify heterogeneity, unique cell subsets or super mutants from thousands of cells within a population. For real-time monitoring of enzyme kinetics and protein expression profiling, valve-based microfluidics or pneumatic valving that can compartmentalize single cells is advantageous by providing on-demand fluid exchange capability for several steps in assay protocol and on-chip culturing. However, this technique is throughput limited by the number of compartments in the array. Thus, one big challenge lies in increasing the number of microvalves to several thousand that can be actuated in the microfluidic device to confine enzymes and substrates in picoliter volumes. This work explores the design and optimizations done on a microfluidic platform to achieve high-throughput single cell compartmentalization as applied to single-cell enzymatic assay for protein expression quantification. Design modeling through COMSOL Multiphysics was utilized to determine the circular microvalve’s optimized parameters, which can close thousands of microchambers in an array at lower sealing pressure. Multiphysical modeling results demonstrated the relationships of geometry, valve dimensions, and sealing pressure, which were applied in the fabrication of a microfluidic device comprising of up to 5000 hydrodynamic traps and corresponding microvalves. Comparing the effects of geometry, actuation media and fabrication technique, a sealing pressure as low as 0.04 MPa was achieved. Applying to single cell enzymatic assay, variations in granzyme B activity in Jurkat and human PBMC cells were observed. Improvement in the microfluidic chip’s throughput is significant in single cell analysis applications, especially in drug discovery and treatment personalization.