bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of Over-The-Counter Analgesics for Pain and Psychological Distress Among Adolescents: A Mixed Effects Approach in Cross-Sectional Survey Data From Norway
Authors: Jonassen Rune , Hilland Eva , Harmer Catherine J. , Abebe Dawit S. , Bergem Anne Kristine , Skarstein Siv 
Published: October 2020

Abstract
Background: Over-the-counter analgesics (OTCA) such as Paracetamol and Ibuprofen are frequently used by adolescents, and the route of administration and access at home allows unsupervised use. Psychological distress and pain occur simultaneously and are more common among females than among males. There is a dynamic interplay between on-label pain indications and psychological distress, and frequent OTCA use or misuse can exacerbate symptoms. No studies have to date provided an overview of frequent OTCA use in a larger population-based study. The current study used survey data to explore associations between and the relative predictive value of on-label pain indication and measures of psychological distress, together with sex differences for weekly OTCA use.Methods: This study included 349,528 adolescents aged 13-19. The data was collected annually between January 2014 and December 2018 as part of the Norwegian Young Data survey. Performance analysis was conducted to explore the relative roles and associations between on-label pain indication and psychological distress in weekly OTCA use. A mixed-effects logistic regression model was used to explore the unique contributions from four domains of on-label pain indication and psychological distress as measured by a combined measure of anxiety and depression (HSCL-10) and peer-bullying involvement as victims or bullies.Results: Thirty percent of females and thirteen percent of males use OTCA weekly. Headache is the strongest on-label pain predictor of weekly OTCA use, followed by abdominal pain. Depression and anxiety are the strongest psychological predictor of weekly OTCA use, and higher symptom levels and being female increase the strength of this association. Anxiety and depression also predict weekly OTCA use after controlling for physiological pain.Conclusions: Sex, pain and anxiety and depression are inter-correlated and strong predictors of frequent OTCA use. Frequent OTCA use in the context of psychological distress may be a form of self-medication that can exacerbate symptoms and decrease psychosocial function. Longitudinal studies that explore causal trajectories between frequent on-label OTCA use and psychological distress are required. OTCA use among adolescents, and particularly among females, with anxiety and depression should be administered with caution and closely monitored.
Closed-loop optogenetic control of normal and pathological network dynamics
Authors: Zaaimi Boubker , Turnbull Mark , Hazra Anupam , Wang Yujiang , de Souza Carolina Gandara , Escobedo-Cousin Enrique , Idil Ahmad , Bailey Richard , Tardio Sabrina , Patel Aaliyah , Ponon Nikhil , Hutchings Frances , Kaiser Marcus , Cunningham Mark , Clowry Gavin , LeBeau Fiona , Constandinou Timothy , Baker Stuart , Donaldson Nick , Degenaar Patrick , O’Neill Anthony , Trevelyan Andrew , Jackson Andrew 
Published: October 2020

Abstract
Electrical neurostimulation is effective in treating neurological disorders, but associated recording artefacts generally limit applications to ‘open-loop’ stimuli. Since light does not prevent concurrent electrical recordings, optogenetics enables real-time, continuous ‘closed-loop’ control of brain activity. Here we show that closed-loop optogenetic stimulation with excitatory opsins (CLOSe) affords precise manipulation of neural dynamics, both in vitro, in brain slices from transgenic mice, and in vivo, with anesthetised monkeys. We demonstrate the generation of oscillations in quiescent tissue, enhancement or suppression of endogenous patterns in active tissue, and modulation of seizure-like bursts elicited by 4-aminopyridine. New network properties, emergent under CLOSe, depended on the phase-shift imposed between neural activity and optical stimulation, and could be modelled with a nonlinear dynamical system. In particular, CLOSe could stabilise or destabilise limit cycles associated with seizure oscillations, evident from systematic changes in the variability and entropy of seizure trajectories that correlated with their altered duration and intensity. Furthermore, CLOSe was achieved using intracortical optrodes incorporating light-emitting diodes, paving the way for translation of closed-loop optogenetics towards therapeutic applications in humans.
Apatinib in Treating Clinical and Biochemical Recurrent Ovarian Cancer
Authors: Wang Zhongyu , Huang Yake , Long Ling , Zhou Li , Huang Yan , Gan Lei , Pu Aimin , Li Sufen , Xie Rongkai 
Published: October 2020

Abstract
Background: Biochemical recurrence is defined according to the combined results of serum carbohydrate antigen and image; noteworthily, it generally precedes the onset of clinical evidence. Now treatment strategies of biochemical recurrence ovarian cancer (OC) remain controversial. Apatinib as monotherapy or in combination with other chemotherapeutic agents has shown its effect in the treatment of some advanced malignancies. In our study, we focused on the efficacy of apatinib in recurrent OC, especially its clinical activity in biochemical-only recurrent OC patients. Methods: We retrospectively analyzed clinical material of 41 recurrent patients who had received apatinib monotherapy or apatinib plus chemotherapy between June 2016 and August 2018. Apatinib was administered at a 500 mg daily dose. Response was determined according to measurable disease or serum carbohydrate antigen (CA)-125 levels. Progression-free survival (PFS) was estimated by Kaplan-Meier method.Results: All patients were evaluable, 19 (46.34%) had biochemical relapse and 22 (53.66%) had clinical relapse. The objective response rate (ORR) and disease control rate (DCR) in the overall population were 31.71% and 78.05%, respectively. The median PFS was 7 months (95% confidence interval 5.43-8.57). And in patients with biochemical-only relapse, the median PFS was 6 months, with ORR of 26.32% and DCR of 89.47%. Conclusions: Apatinib is a well-tolerated and effective agent to delay clinical progression of patients with biochemical-only recurrent OC. More important, our study shows the promising prospect for treating OC patients with asymptomatic biochemical relapse.
Bioinformatics Analysis and Insights for The Role of COMMD7 in Hepatocellular Carcinoma
Authors: Peng Xuehui , He Yonggang , Huang Xiaobing , You Nan , Gu Huiying , Dong Rui , Yang Xiaomin , Zheng Lu , Li Jing 
Published: October 2020

Abstract
Background: The tumorigenesis and development of hepatocellular carcinoma (HCC) is a process involving multiple factors. The COMMDs family proteins were reported to play important roles in various disease and cancers including HCC. We previously found COMMD7 acted as a HCC-promotion factor; however, further understanding on COMMD7 was needed. We conducted these bioinformatics analysis for the purpose of comprehensive understanding of the functional role of COMMD7 in HCC.Methods: The bioinformatics analysis of COMMD7 were launched by online platforms including KEGG, GEPIA, cBioportal, Gene Ontology and The Kaplan-Meier plotter. Data from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) were downloaded, and the data analysis and processing were conducted by RStudio (version 1.3.959) software.Results: The expression profile results of COMMD7 in TCGA and GTEx database suggested that COMMD7 expressed highly in liver tumor tissues and positively related with poorer prognosis (p<0.01); COMMD7 also contributed to the early development of HCC as its higher expression resulted in progression from stage I to stage III (p<0.01). Based on our previous studies, COMMD7 may target NF-κB signaling and CXCL10 to enhance the proliferation of hepatoma cells so that promoting the development of HCC. Conclusions：This study updates the current studies about the newly recognized roles of COMMD7 in the progression of HCC, summarizing the research progress and prospects of COMMD7 comprehensively, offering an outlook for the future investigation and targeted therapy of HCC.
Within-host Evolution of Acinetobacter Baumannii in Clinical Bacteremia Patients
Authors: Li Henan , Zhang Jiangang , Wang Zhiren , Yin Yuyao , Gao Hua , Wang Ruobing , Jin Longyang , Wang Qi , Zhao Chunjiang , Wang Zhanwei , Wang H. 
Published: October 2020

Abstract
Background: Acinetobacter baumannii colonizing the respiratory tract has been established as an independent risk factor for bacteremia. However, within-host evolution of A. baumannii in bacteremia has not been extensively investigated. Here we performed whole genome sequencing to discover the evolutionary characteristics that accompany the transition from respiratory tract carriage to bloodstream infection in three A. baumannii bacteremia patients.Results: Within-host genetic diversity was identified. A total of twenty-one SNVs were detected. Genic and intergenic evolution occurred particularly in secretion system, DNA recombination and cell motility genes. Intergenic SNVs occurred more frequently than synonymous and non-synonymous SNVs, which indicated potential transcription or translation regulation. Non-synonymous mutations mostly occurred during the transition from the respiratory tract carriage to the bloodstream infection. Isolates of clonal complex 208 (CC208) had lower substitution rate with approximately 10-6 nucleotide substitutions per site year-1, compared with non CC208 isolates (approximately 10-5). We found evidence for the occurrence of recombination in one patient. Gene content showed patient specificity, and isolates within a single host had constrained gene content diversity.Conclusions: Our results indicated that high within-host diversity was driven by rapid mutation rates and limited effect of recombination in A. baumannii from respiratory tract carriage to bacteremia.
Pregnancy Readiness in Married Female Adolescents from Different Ethnic Groups in Probolinggo District, Indonesia
Authors: Sumarmi Sri , Laksono Agung Dwi 
Published: October 2020

Abstract
Background: Physical readiness for pregnancy potentially affects the new born’s health status. The study aims to analyze pregnancy readiness in married female adolescents.Methods: Data were collected in Probolinggo District, Indonesia from 2012-2014. This study involved 760 married female adolescents (< 20 years old) as the analysis units. There are 2 major ethnic groups in Probolinggo District (Javanese and Madurese), as well as a small number of other ethnic groups. The study’s dependent variable was pregnancy readiness, while its independent variable was ethnicity. In addition, other independent variables were also analyzed, for example, marital status, age, education, and employment. The final analysis was done using a binary logistic regression. Pregnancy readiness variable was seen from other sub-variables, such as anemia status, body weight, stature, nutritional status, and mid-upper-arm circumference. Results: Married female adolescents mostly suffered from anemia. The respondents mostly had normal anthropometry. Regarding pregancy readiness variable, married female adolescents from all ethnicities married female adolescentswere not ready to get pregnant. Madurese married female adolescents were 0.563 times readier to get pregnant compared to Javanese married female adolescents (OR 0.563; 95% CI 0.369-0.857). There was no significant difference between Madurese ethnic adolescents and the Java-Madurese ones and others. Moreover, there was no significant difference between educational levels and the respondents’ readiness for pregnancy. Conclusions: There were partial differences in readiness for pregancy in married female adolescents from different ethnic groupsmarried female adolescents. Madurese married female adolescents had a lower possibility of prenancy readiness than Javanese ones.
Baseload power potential from optimally-configured wind, solar and storage power plants across the United States
Authors: Rhodes Joshua D , Choukulkar Aditya , Cote Brianna , McKee Sarah A , Clack Christopher T M 
Published: October 2020

Abstract
In the present paper, we assessed the potential for local wind, solar PV, and energy storage to provide baseload (constant, uninterrupted) power in every county of the contiguous United States. The amount of available capacity between 2020 and 2050 was determined via a least-cost optimization model that took into account changing costs of constituent technologies and local meteorological conditions. We found that, by 2050, the potential exists for about 6.8 TW of renewable baseload power at an average cost of approximately $50 / MWh, which is competitive with current wholesale market rates for electricity. The optimal technology configurations constructed always resulted in over two hours of emergency energy reserves, with the amount increasing as the price of energy storage falls. We also found that, given current price decline trajectories, the model has a tendency to select more solar capacity than wind over time. A second part of the study performed three million simulations followed by a regression analysis to generate an online map-based tool that allows users to change input costs assumptions and compute the cost of renewable baseload electricity in every contiguous US county.
Assessment of the current levels of 241Am and 137Сs in soils and foodstuff, as well as of public internal exposure to ionizing radiation in populated areas adjacent to the Chernobyl NPP exclusion zone (case study: the Bragin district of the Gomel region, Belarus)
Authors: Nilova E. K. , Bortnovsky V. N. , Tagai S. A. , Dudareva N. V. , Nikitin A. N. 
Published: October 2020

This paper is part of a research cycle focusing on studying the current levels of 241Am and 137Cs in soils and local foodstuffs of populated areas neighboring the Chernobyl exclusion zone. Our objective was to estimate the maximum annual committed internal doses to individuals of the Bragin-area settlements from inhalation and consumption of locally produced foods. We updated the data on the levels of 241Am and 137Сs in soils of 28 settlements of the district. Specific activity of 241Am in soils in two of the settlements were the highest of all; we took and analyzed samples of local-grown foodstuff. 241Am in food samples was measured via a radiochemical method with the use of selective chromatographic resins and alpha-spectrometry measurement. A gammaspectrometry technique was used to measure 241Am in soil and 137Сs in soil and food samples. The most contaminated by 241Am and 137Cs appeared the soils in the town of Bragin, the administrative center of the district where the respective levels were as high as 2.8 and 560 kBq/m2. Among the analyzed samples, the specific activities of 241Am in root and tuber crops were one-digit values, while the samples of leafy vegetables contained a few tens of mBq/kg of the same radionuclide. That said, however, 241Am concentrations in food samples were lower than those of 137Сs by three orders of magnitude. The results showed an apparent difference between estimated annual committed internal doses to the Bragin residents due to 241Am intake and that resulting from 137Сs with the respective 0.03 and 1.7 mSv/year. The maximum doses to population of the Bragin-district villages from inhalation of 241Am varied from 0.006 to 0.033 mSv/year exceeding the doses from inhaled 137Сs – 0.0002-0.002 mSv/year – by one order of magnitude. The major contribution to the public internal exposure today is 137Сs intake through consumption of contaminated food that produced locally; its contribution is about 93-99% of the total internal dose received by the Bragin-district residents.
Statistical Explanatory Assessment of Groundwater Quality in Gwale LGA, Kano State, Northwest Nigeria
Authors: Suleiman Ahmad , Ibrahim Auwalu , Abdullahi Usman 
Published: October 2020

Groundwater is one of the significant sources of drinking water in the world. To protect groundwater quality for domestic consumption, it is important to undertake a periodic investigation of its quality to improve the healthy living of the ever-increasing population. In this paper, we have analyzed physical and chemical (physicochemical) concentration levels in groundwater samples collected from twenty-eight sampling locations during the raining season in Gwale, Northwest Nigeria. About fifteen physicochemical parameters such as electric conductivity (EC), turbidity (Turb), pH, temperature (Temp), nitrate (NO3), phosphate (PO4), total dissolved solid (TDS), chloride (Cl), sulphate (SO4), calcium (Ca), magnesium (mg), sodium (Na), total hardness (TH), iron (Fe) and alkalinity (Alk) were analyzed. The concentrations levels of groundwater parameters in each sampling location were compared with the permissible limits of drinking water qualities specified by the Nigerian Industrial Standard (NIS) to determine the suitability of drinking water in the study area. Karl Pearson’s coefficient of correlation was applied to the groundwater dataset to identify the influence of each physicochemical parameter to the groundwater contamination. Also, hierarchical cluster analysis was used to classify the groundwater samples based on contamination density as well as to identify the sources of water contamination. The results from correlation analysis revealed that EC, TDS, Ca, TH, Mg, SO4, Na and Cl were influenced the water contamination in many of the study locations based on the conventional significance levels (1% and 5%). From the results of cluster analysis, three statistically significant groups (cluster 1, cluster 2 and cluster 3) were formed which were defined as lower contaminated areas, moderately contaminated areas and higher contaminated areas, respectively. The contamination levels identified in the three clusters were attributed to anthropogenic and industrial activities in the raining season. Therefore, groundwater from cluster 3 (Salanta, Hauren makaranta, Dandago, Mandawari and Magashi) are found unsuitable for drinking. This study is useful in monitoring groundwater quality and could be applied in any other location.
Performance and reliability comparison of French vertical flow treatment wetlands with other decentralized wastewater treatment technologies in tropical climates
Authors: Lombard-Latune Rémi , Leriquier Florent , Oucacha Chafatayne , Pelus Lucas , Lacombe Gérald , Le Guennec Bernard , Molle Pascal 
Published: October 2020

Abstract
When implementing a sanitation system, the selection of treatment process can be difficult. Beyond removal efficiency and effluent concentrations, reliability should be taken into account. This study compares reliability of French vertical flow treatment wetlands (F-VFTW) with the four main decentralized wastewater treatment technologies in small communities in the French Overseas Territories (FOT).
Analysis of 963 regulatory self-monitoring sampling campaigns performed on 213 wastewater treatment plants show that operational disruptions due to sludge loss and loss of nitrification are often reported for activated sludge technology; rotating biological contactors often suffer from weak settlement; facultative pond removal is limited by algae; and F-VFTW fulfills all the French regulatory objectives at a frequency of 90 to 95%.
In addition, the data from this study are compared to a similar database from Brazil using a statistical approach (coefficient of reliability). Amongst the eight decentralized wastewater treatment technologies evaluated, F-VFTW appears to be the most appropriate for achieving the discharge standard with a reliability close to 95%. Its reliability to face both environmental (rainfall) and social (maintenance capacities) constraints is a key parameter.
Evaluasi manajemen Program Sekolah Siaga Bencana (SSB)
Authors: Tyas Rizki Arumning , Pujianto Pujianto , Suyanta Suyanta 
Published: October 2020

Penelitian ini bertujuan untuk mendeskripsikan manajemen sekolah siaga bencana (SSB) di SMP N 2 Cangkringan. Penelitian ini merupakan penelitian kualitatif pendekatan studi kasus. Subjek penelitian adalah kepala sekolah, guru mata pelajaran IPA, guru mata pelajaran IPS, serta kepala tata usaha selaku koordinator pelaksana program SSB. Teknik pengumpulan data menggunakan wawancara, observasi, dan dokumentasi. Analisis data menggunakan model interactive Miles dan Huberman, yang meliputi kondensasi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa perencanaan program SSB di SMP N 2 Cangkringan diawali dengan penyamaan persepsi dan komitmen antar warga sekolah, dilanjutkan dengan pembuatan rencana kontinjensi bersama warga sekolah dengan komite sekolah dan instansi terkait. Perencanaan diikuti kajian tingkat kesiapsiagaan sekolah serta peningkatan kapasitas dalam bentuk pelatihan untuk semua stakeholder sekolah. Sekolah telah melaksanakan simulasi atau drill pelatihan menghadapi bencana. Namun, belum dilaksanakan evaluasi keterlaksanaan program SSB secara menyeluruh sehingga demi tercapainya tujuan SSB secara maksimal masih diperlukan banyak peningkatan dan dukungan dari berbagai pihak. AbstractThis research aimed to describe the management of a disaster preparedness programs in SMP N 2 Cangkringan. This research was a qualitative case study approach. The research subjects were the school principal, science subject teacher, social studies teacher, and head of administration as program coordinator. Data collected by interviews, observation, and documentation. Miles and Huberman's model, which included data condensation, data presentation, and conclusion drawing was applied to analyze the data. The results show that the planning of the program began to make an equal perception and commitment among school residents, followed by making contingency plans together with the school community, school committee, and related agencies. Planning is followed by a study of school preparedness levels and capacity building in the form of training for all school stakeholders. The school has carried out a disaster training drill or simulation. However, a comprehensive evaluation of the program has not yet been carried out, so that in order to achieve the program’s objectives, many improvements and support from various parties are still needed.