bluuebunny/crossref_metadata_2025_split huggingface dataset:
A drug–drug interaction study of a novel, selective urate reabsorption inhibitor dotinurad and the non-steroidal anti-inflammatory drug oxaprozin in healthy adult males
Authors: Furihata Kenichi , Nagasawa Katsuaki , Hagino Atsushi , Kumagai Yuji 
Published: February 2020

Abstract
Background
Dotinurad is a novel, selective urate reabsorption inhibitor, which reduces serum uric acid levels by inhibiting the urate transporter 1. The results of nonclinical studies indicated the possibility that the concomitant use of the non-steroidal anti-inflammatory drug oxaprozin affects the pharmacokinetics of dotinurad. We evaluated drug–drug interactions with respect to the pharmacokinetics and safety of dotinurad when co-administered with oxaprozin.

Methods
This was an open-label, two-period, add-on study in healthy adult males. For a single dose of 4 mg of dotinurad with and without oxaprozin, we compared its pharmacokinetic parameters and evaluated safety.

Results
This study enrolled 12 subjects, 11 of whom completed the study. The geometric mean ratio (90% confidence interval [CI]) of the urinary excretion rate of glucuronate conjugates of dotinurad after co-administration with oxaprozin compared to administration of dotinurad alone was 0.657 (0.624–0.692), while the geometric mean ratios (90% CIs) of the maximum plasma concentration and area under the plasma concentration–time curve from time zero to infinity (AUC0–inf) were 0.982 (0.945–1.021) and 1.165 (1.114–1.219), respectively. During the study, two adverse events occurred after administration of dotinurad alone and one occurred after administration of oxaprozin alone.

Conclusions
In comparison with administration of dotinurad alone, co-administration with oxaprozin was associated with a 34.3% decrease in the urinary excretion rate of the glucuronate conjugates of dotinurad, and a 16.5% increase in AUC0–inf of dotinurad. However, no clinically meaningful drug–drug interactions were observed. Administration of dotinurad alone was similar safety to co-administration with oxaprozin.

Clinical trial registration
ClinicalTrials.gov Identifier: NCT03350386.
Influence of Isothermal Holding on the Microstructure and Mechanical Properties of Electron Beam Welded Dissimilar Inconel 718/ATI 718Plus® Joint
Authors: Dziuba Oskar , Cempura Grzegorz , Wusatowska-Sarnek Agnieszka , Kruk Adam 
Published: February 2020

AbstractMicrostructural changes of the Inconel 718 and ATI 718Plus® base materials and the fusion zone caused by the isothermal hold at 760 °C for up to 500 h were investigated. The evaluation was performed using a scanning electron microscope with backscattered electrons detector and scanning transmission electron microscopy supported by energy-dispersive x-ray spectroscopy. Furthermore, to evaluate the effect of microstructural changes on mechanical properties Vickers microhardness measurements were performed. Exposure of welded joint at high temperature led to coarsening and/or dissolution of main strengthening phases’ particles and nucleation and growth of plate-like precipitates. In the interdendritic region of the fusion zone, the transformation of the Laves phase to a complex cluster of precipitates contained σ phase had taken place. Analysis of microstructure and microhardness measurements showed that ATI 718Plus has better mechanical properties and microstructural stability at elevated temperature than Inconel 718.
Component processes of detection probability in camera-trap studies: understanding the occurrence of false-negatives
Authors: Findlay Melanie A. , Briers Robert A. , White Patrick J. C. 
Published: February 2020

AbstractCamera-trap studies in the wild record true-positive data, but data loss from false-negatives (i.e. an animal is present but not recorded) is likely to vary and widely impact data quality. Detection probability is defined as the probability of recording an animal if present in the study area. We propose a framework of sequential processes within detection – a pass, trigger, image registration, and images being of sufficient quality. Using closed-circuit television (CCTV) combined with camera-trap arrays we quantified variation in, and drivers of, these processes for three medium-sized mammal species. We also compared trigger success of wet and dry otterLutra lutra, as an example of a semiaquatic species. Data loss from failed trigger, failed registration and poor capture quality varied between species, camera-trap model and settings, and were affected by different environmental and animal variables. Distance had a negative effect on trigger probability and a positive effect on registration probability. Faster animals had both reduced trigger and registration probabilities. Close passes (1 m) frequently did not generate triggers, resulting in over 20% data loss for all species. Our results, linked to the framework describing processes, can inform study design to minimize or account for data loss during analysis and interpretation.
Train–track coupled dynamics analysis: system spatial variation on geometry, physics and mechanics
Authors: Xu Lei , Zhai Wanming 
Published: February 2020

AbstractThis paper aims to clarify the influence of system spatial variability on train–track interaction from perspectives of stochastic analysis and statistics. Considering the spatial randomness of system properties in geometry, physics and mechanics, the primary work is therefore simulating the uncertainties realistically, representatively and efficiently. With regard to the track irregularity simulation, a model is newly developed to obtain random sample sets of track irregularities by transforming its power spectral density function into the equivalent track quality index for representation based on the discrete Parseval theorem, where the correlation between various types of track irregularities is accounted for. To statistically clarify the uncertainty of track properties in physics and mechanics in space, a model combining discrete element method and finite element method is developed to obtain the spatially varied track parametric characteristics, e.g. track stiffness and density, through which the highly expensive experiments in situ can be avoided. Finally a train–track stochastic analysis model is formulated by integrating the system uncertainties into the dynamics model. Numerical examples have validated the accuracy and efficiency of this model and illustrated the effects of system spatial variability on train–track vibrations comprehensively.
Wenn Ethik zum Programm wird: Eine risikoethische Analyse moralischer Dilemmata des autonomen Fahrens
Authors: Schäffner Vanessa 
Published: February 2020

ZusammenfassungWie sollen sich autonome Fahrzeuge verhalten, wenn ein Unfall nicht mehr abwendbar ist? Die Komplexität spezifischer moralischer Dilemmata, die in diesem Kontext auftreten können, lässt bewährte ethische Denktraditionen an ihre Grenzen stoßen. Dieser Aufsatz versteht sich als Versuch, neue Lösungsperspektiven mithilfe einer risikoethischen Sichtweise auf die Problematik zu eröffnen und auf diese Weise deren Relevanz für die Programmierung von ethischen Unfallalgorithmen aufzuzeigen. Im Zentrum steht dabei die Frage, welche Implikationen sich aus einer Auffassung von Dilemma-Situationen als risikoethische Verteilungsprobleme im Hinblick auf die Zulässigkeit von entsprechenden Risikoübertragungen ergeben. Dabei wird zunächst eine risikoethische Interpretation des zugrundeliegenden Entscheidungsproblems skizziert, welches durch seine dilemmatische Struktur eine besondere Risikokonstellation begründet. Ausgehend von den Positionen von Sven Ove Hansson und Julian Nida-Rümelin wird für einen deontologisch-risikoethischen Ansatz argumentiert, der auf Individualrechten einerseits und einer interpersonell gerechten Verteilung der entstehenden Schadensrisiken anderseits basiert. Diese beiden Kriterien werden für den Anwendungskontext des autonomen Fahrens konkretisiert. Zum einen wird in Bezug auf das erste Kriterium argumentiert, dass individuelle Rechte genau dann als angemessen gewahrt gelten können, wenn die resultierenden Risikoübertragungen auf die Einzelnen in ihrer absoluten Höhe jeweils zumutbar sind (absolutes Prinzip). Zum anderen werden Schwierigkeiten skizziert, die sich hinsichtlich der konkreten Umsetzung des zweiten Kriteriums der Verteilungsgerechtigkeit (relatives Prinzip) ergeben. In diesem Zusammenhang werden beispielsweise ethische Herausforderungen in Bezug auf einen möglichen Vorteilsausgleich, das Prinzip der Schadensminimierung sowie individuell unterschiedliche Ausgangsbedingungen der persönlichen Schadensreduktion kritisch in den Blick genommen.
Study on applicability of two modal identification techniques in irrelevant cases
Authors: Tomaszewska A. , Szafrański M. 
Published: February 2020

AbstractStudy on applicability of two modal identification techniques in irrelevant cases is made in this paper. The following techniques are considered: peak picking based on correlation analysis (PP-CA), dedicated for ambient vibrations and eigensystem realization algorithm (ERA), formulated for free-decay vibrations investigation. Irrelevant cases are found when analyzed signals are different than recommended to a given technique. The study is conducted on examples of two real structures: masonry tower and steel railway bridge. Both cases are diverse in age, material, excitation and vibrations energy. The signals measured on the tower are suitable for the PP-CA technique (ambient vibrations), while the signals measured on the bridge are suitable for the ERA (free-decay vibrations). However, both methods have been applied to both systems. Natural frequencies, mode shapes and damping ratios are identified and the effectiveness of the irrelevant technique is assessed in relation to the results obtained by the relevant method in each case.
Diverse Sexual Behaviors and Pornography Use: Findings From a Nationally Representative Probability Survey of Americans Aged 18 to 60 Years
Authors: Herbenick Debby , Fu Tsung-Chieh , Wright Paul , Paul Bryant , Gradus Ronna , Bauer Jill , Jones Rashida 
Published: February 2020

Abstract

Background
Convenience sample data indicate that substantial portions of adults have engaged in sexual behaviors sometimes described as rough; little is known about these behaviors at the population level.

Aim
To describe, in a U.S. probability sample of Americans aged 18 to 60 years, (i) the prevalence of diverse sexual behaviors, described here as dominant and target behaviors; (ii) the age at first pornography exposure as well as prevalence, range, and frequency of pornography use; (iii) the association between past year pornography use frequency and dominant/target sexual behaviors; and (iv) associations between lifetime range of pornography use and dominant/target sexual behaviors.

Methods
A confidential cross-sectional online survey was used in this study.

Outcomes
Lifetime engagement in dominant behaviors (eg, spanking, choking, name calling, performing aggressive fellatio, facial ejaculation, penile-anal penetration without first asking/discussing) and lifetime engagement in target behaviors (eg, being spanked, being choked, being called names during sex, having their face ejaculated on, receiving aggressive fellatio, or receiving penile-anal penetration without having discussed) were assessed; lifetime pornography use, age at first porn exposure, past-year frequency of porn viewing, and lifetime range of pornography were also assessed.

Results
Women as well as men who have sex with men were more likely to report target sexual behaviors: having been choked (21.4% women), having one's face ejaculated on (32.3% women, 52.7% men who have sex with men), and aggressive fellatio (34.0% women). Lifetime pornography use was reported by most respondents. After adjusting for age, age at first porn exposure, and current relationship status, the associations between pornography use and sexual behaviors was statistically significant.

Clinical Implications
Clinicians need to be aware of recent potential shifts in sexual behaviors, particularly those such as choking that may lead to harm.

Strengths & Limitations
Strengths include U.S. probability sampling to provide population level estimates and the use of Internet-based data collection on sensitive topics. We were limited by a lack of detail and context related to understanding the diverse sexual behaviors assessed.

Conclusion
Clinicians, educators, and researchers have unique and important roles to play in continued understanding of these sexual behaviors in the contemporary United States.
Role of Religious Institutions in Disaster Risk Management: A Systematic Review
Authors: Sheikhi Rahim Ali , Seyedin Hesam , Qanizadeh Ghader , Jahangiri Katayoun 
Published: February 2020

ABSTRACTObjectives:The aim of this systematic review is to analyze the relevant research on religious organizations’ participation in disasters risk management and to understand the ways in which these organizations impact on disaster management. Today, community-based disaster risk management is emphasized as a very effective approach. Religious organizations are one of the most important components of community. They have access to resources that can be critical to help government agencies to manage disasters successfully.Methods:This systematic review was conducted since August 2018 to investigate the role of religious institutions in disasters management and was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed, Web of Science (WOS), Scopus, Proquest, Embase, and Google scholar were the primary databases used for search of literature. Keywords used in this review were “religious institution,” “disaster management,” and their equivalents were obtained from Mesh, Emtree, or extracted from related articles. The papers from a broad range of disciplines related to keywords were included, and those articles that focus on response to disaster based on religious beliefs’ and religion rather than participation of religious institutions in disaster risk management were excluded. From the 18,071 records identified through database searching in the early stage, 22 articles were selected for this review followed by analysis of the characteristics and content analysis of the included studies to answer the study questions.Results:The findings of this systematic review that emerged from content analysis are summarized in 11 themes: religious institutions’ potential for disaster management, preparedness of religious institutions for disasters, response, recovery, the social capital, partnership with all stakeholders, collaboration and communication between mental health professionals and faith-based organization leaders, unity of information and message, religious institution shelters, dealing with disaster in old and new approaches, and barriers and challenges.Conclusions:Religious institutions have a vital role and great potential in disasters management. They often contribute in response and recovery phases of disasters, although these services are valuable but the great potential of these groups should also be recruited to participate in preparedness and mitigation efforts as part of disasters cycle. Coordination and collaboration of all stakeholders is essential in this way.
Rebels, Revenue and Redistribution: The Political Geography of Post-Conflict Power-Sharing in Africa
Authors: Haass Felix , Ottmann Martin 
Published: February 2020

AbstractDo rebel elites who gain access to political power through power-sharing reward their own ethnic constituencies after war? The authors argue that power-sharing governments serve as instruments for rebel elites to access state resources. This access allows elites to allocate state resources disproportionately to their regional power bases, particularly the settlement areas of rebel groups' ethnic constituencies. To test this proposition, the authors link information on rebel groups in power-sharing governments in post-conflict countries in Africa to information about ethnic support for rebel organizations. They combine this information with sub-national data on ethnic groups' settlement areas and data on night light emissions to proxy for sub-national variation in resource investments. Implementing a difference-in-differences empirical strategy, the authors show that regions with ethnic groups represented through rebels in the power-sharing government exhibit higher levels of night light emissions than regions without such representation. These findings help to reconceptualize post-conflict power-sharing arrangements as rent-generating and redistributive institutions.
THE CASCAJAL BLOCK: NEW LINE DRAWING, DISTRIBUTIONAL ANALYSIS, AND ORTHOGRAPHIC PATTERNS
Authors: Mora-Marín David F. 
Published: February 2020

AbstractThis paper studies the Cascajal Block, a serpentinite artifact with an Olmec text dating to ca. 1000–900b.c.(Rodríguez Martínez et al. 2006a). It introduces a new line drawing made possible by the detailed documentation carried out by Carrasco and Englehardt, presents a distributional analysis of the inscription in order to assess the sign inventory proposed by Rodríguez Martínez et al. (2006a) and revised by Mora-Marín (2009), and, most significantly, suggests that certain irregularities in the patterns of sign co-occurrence raised by previous authors (Justeson 2012; Macri 2006) are consistent with spelling practices in logosyllabic scripts, showing that the script is linguistically motivated. The work by Carrasco and Englehardt (2015) on the identification and analysis of sign pairings as likely diphrastic kennings is highlighted as crucial to establishing semantic controls needed for any attempt at decipherment; a new, repeated pairing is proposed, consisting of the PELT-PAW signs. Finally, this paper assesses how the various models for the reading formatting and direction of the text could impact the proposed hypotheses.
Early and late outcomes of surgical repair of double-chambered right ventricle: a single-centre experience
Authors: Surucu Murat , Erdoğan İlkay , Varan Birgül , Özkan Murat , Tokel N. Kürşad , Aşlamacı Sait 
Published: February 2020

AbstractObjective:Double-chambered right ventricle is characterised by division of the outlet portion of the right ventricle by hypertrophy of the septoparietal trabeculations into two parts. We aim to report our experiences regarding the presenting symptoms of double-chambered right ventricle, long-term prognosis, including the recurrence rate and incidence of arrhythmias after surgery.Methods:We retrospectively investigated 89 consecutive patients who were diagnosed to have double-chambered right ventricle and underwent a surgical intervention from 1995 to 2016. The data obtained by echocardiography, cardiac catheterisation, and surgical findings as well as post-operative follow-up, surgical approaches, post-operative morbidity, mortality, and cardiac events were evaluated.Results:Median age at the time of diagnosis was 2 months and mean age at the time of operation was 5.3 years. Concomitant cardiac anomalies were as follows: perimembranous ventricular septal defect (78 patients), atrial septal defect (9 patients), discrete subaortic membrane (32 patients), right aortic arch (3 patients), aortic valve prolapse and/or mild aortic regurgitation (14 patients), and left superior caval vein (2 patients). The mean follow-up period was 4.86 ± 4.6 years. In these patients, mean systolic pressure gradient in the right ventricle by echocardiography before, immediately, and long-term after surgical intervention was 66.3, 11.8, and 10.4 mmHg, respectively. There were no deaths during the long-term follow-up period. Surgical reinterventions were performed for residual ventricular septal defect (2), residual pulmonary stenosis (1), and severe tricuspid insufficiency (1).Conclusion:The surgical outcomes and prognosis of double-chambered right ventricle are favourable, recurrence and fatal arrhythmias are unlikely in long-term follow-up.
Experience with balloon pulmonary valvuloplasty and predictors of outcome: a ten-year study
Authors: El-Saeidi Sonia A. , Hamza Hala S. , Agha Hala M. , Soliman Mohammed M. , Attia Wael A. , El-Kaffas Rania , Abdel-Aziz Faten , Abdel-Aziz Osama , Shaker Sahar , Esmat Amira , Ammar Rasha , Fattouh Aya , Mohi-eldin Khalid , El-Sisi Amal M. 
Published: February 2020

AbstractBackground:Balloon pulmonary valvuloplasty is the treatment of choice for patients with moderate to severe pulmonary valve stenosis.Methods:An observational retrospective cross-sectional study including neonates, small infants, and children who underwent balloon pulmonary valvuloplasty in the period from 2007 to 2016 in the cardiac catheterisation unit of the paediatric cardiology department in Cairo University. Multivariable models were built to report the predictors of the outcome of balloon pulmonary valvuloplasty and its complications.Results:A total of 1200 patients were included in the study and divided according to age into 3 groups: neonates and early infants (n = 282), infants (n = 362), and children (n = 556). Procedural success, defined as a drop pressure gradient across the pulmonary valve to less than or equal to 50% of the baseline measurements, was achieved in 82.7% of the patients. Multivariate analysis revealed that only infundibular pulmonary stenosis (p value 0.032), supravalvular in association with valvular pulmonary stenosis (p value <0.001), and pulmonary valve diameter by angiogram (p value <0.001) were significant predictors of success. The presence of supravalvular in association with valvular pulmonary stenosis (p value <0.001) was associated with a lower weight (p value 0.007) and higher right ventricular pressure before the intervention (p value <0.001), and a minor immediate drop in the pressure gradient post-intervention (p value <0.001) was found to be the most significant predictor of the occurrence of complications.Conclusion:The absence of infundibular and supravalvular stenosis and a large pulmonary valve diameter were the most significant predictors of success.
Adaptive control in interpreters: Assessing the impact of training and experience on working memory
Authors: Nour Soudabeh , Struys Esli , Stengers Helene 
Published: February 2020

AbstractThe adaptive control hypothesis predicts adaptation of control mechanisms as a response to intensive language use in bilinguals. The present study aims to investigate this hypothesis in two memory experiments with professional and student interpreters. In experiment 1, we compared a group of interpreting students to translation students using a reading span task to test working memory (WM) and a digit span task to test short-term memory (STM). In experiment 2, we added a group of professional interpreters and compared them with the participants in experiment 1. Training-related improvement was found for WM but not for STM, with no differences between both student groups. Professional interpreters with over 20 years of interpreting experience showed better performance than translation students but not than interpreting students both on WM and STM. The results are discussed in light of the framework of interpreting as a type of extreme bilingualism.