bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with mammography use: A side‐by‐side comparison of results from two national surveys
Authors: Li Lihua , Ji Jiayi , Besculides Melanie , Bickell Nina , Margolies Laurie R. , Jandorf Lina , Taioli Emanuela , Mazumdar Madhu , Liu Bian 
Published: July 2020

AbstractBackgroundMammography use is affected by multiple factors that may change as public health interventions are implemented. We examined two nationally representative, population‐based surveys to seek consensus and identify inconsistencies in factors associated with mammography use in the entirety of the US population, and by black and white subgroups.MethodsSelf‐reported mammography use in the past year was extracted for 12 639 and 169 116 women aged 40‐74 years from the 2016 National Health Interview Survey (NHIS) and the 2016 Behavioral Risk Factor Surveillance System (BRFSS), respectively. We applied a random forest algorithm to identify the risk factors of mammography use and used a subset of them in multivariable survey logistic regressions to examine their associations with mammography use, reporting predictive margins and effect sizes.ResultsThe weighted prevalence of past year mammography use was comparable across surveys: 54.31% overall, 54.50% in white, and 61.57% in black in NHIS and 53.24% overall, 56.97% in white, and 62.11% in black in BRFSS. Overall, mammography use was positively associated with black race, older age, higher income, and having health insurance, while negatively associated with having three or more children at home and residing in the Western region of the US. Overweight and moderate obesity were significantly associated with increased mammography use among black women (NHIS), while severe obesity was significantly associated with decreased mammography use among white women (BRFSS).ConclusionWe found higher mammography use among black women than white women, a change in the historical trend. We also identified high parity as a risk factor for mammography use, which suggests a potential subpopulation to target with interventions aimed at increasing mammography use.
Lung cyst and multinodular thyroid goiter: Keys to DICER1 syndrome diagnosis in a 16‐year‐old female
Authors: Tutor James D. , Miller Stephen F. , Al Zubeidi Hiba , Sheyn Anthony , Zhang Jie , Williams Regan , McGee Rose B. 
Published: July 2020

AbstractPulmonary cysts and neoplasms, especially congenital or occurring at a young age, should be thoroughly investigated. Evaluation for DICER1 mutations should be performed if there is a family history of this syndrome, the lung cyst/neoplasm is a pleuropulmonary blastoma, or other clinical manifestations of this syndrome are present or develop.
A case of gastric cardia telangiectasias and primary biliary cirrhosis with hemorrhage
Authors: Guo Jinsheng 
Published: July 2020

AbstractIn patients presenting with persistent anemia and gastric cardia telangiectasias, a potential etiology of portal hypertension due to chronic liver disease, especially primary biliary cirrhosis, should be considered. Drugs for treating specific liver disease and lowering portal hypertension are effective strategies to prevent hemorrhage.
Cytochrome c Reductase is a Key Enzyme Involved in the Extracellular Electron Transfer Pathway towards Transition Metal Complexes in Pseudomonas Putida
Authors: Lai Bin , Bernhardt Paul V. , Krömer Jens O. 
Published: July 2020

AbstractMediator‐based extracellular electron transfer (EET) pathways can balance the redox metabolism of microbes. However, such electro‐biosynthesis processes are constrained by the unknown underlying EET mechanisms. In this paper, Pseudomonas putida was studied to systematically investigate its EET pathway to transition metal complexes (i. e., [Fe(CN)6]3−/4− and [Co(bpy)3]3+/2+; bpy=2,2′‐bipyridyl) under anaerobic conditions. Comparative proteomics showed the aerobic respiratory components were upregulated in a bioelectrochemical system without oxygen, suggesting their potential contribution to EET. Further tests found inhibiting cytochrome c oxidase activity by NaN3 and NADH dehydrogenase by rotenone did not significantly change the current output. However, the EET pathway was completely blocked, while cytochrome c reductase activity was inhibited by antimycin A. Although it cannot be excluded that cytochrome c and the periplasmic subunit of cytochrome c oxidase donate electrons to the transition metal complexes, these results strongly demonstrate that cytochrome c reductase is a key complex for the EET pathway.
Rapid within‐ and transgenerational changes in thermal tolerance and fitness in variable thermal landscapes
Authors: Cavieres Grisel , Rezende Enrico L. , Clavijo‐Baquet Sabrina , Alruiz José M. , Rivera‐Rebella Carla , Boher Francisca , Bozinovic Francisco 
Published: July 2020

AbstractPhenotypic plasticity may increase the performance and fitness and allow organisms to cope with variable environmental conditions. We studied within‐generation plasticity and transgenerational effects of thermal conditions on temperature tolerance and demographic parameters inDrosophila melanogaster. We employed a fully factorial design, in which both parental (P) and offspring generations (F1) were reared in a constant or a variable thermal environment. Thermal variability during ontogeny increased heat tolerance in P, but with demographic cost as this treatment resulted in substantially lower survival, fecundity, and net reproductive rate. The adverse effects of thermal variability (V) on demographic parameters were less drastic in flies from the F1, which exhibited higher net reproductive rates than their parents. These compensatory responses could not totally overcome the challenges of the thermally variable regime, contrasting with the offspring of flies raised in a constant temperature (C) that showed no reduction in fitness with thermal variation. Thus, the parental thermal environment had effects on thermal tolerance and demographic parameters in fruit fly. These results demonstrate how transgenerational effects of environmental conditions on heat tolerance, as well as their potential costs on other fitness components, can have a major impact on populations’ resilience to warming temperatures and more frequent thermal extremes.
Hanger replacement influence on seismic response of suspension bridges: Implementation to the Bosphorus Bridge subjected to multi‐support excitation
Authors: Bas Selcuk , Dong Chuan‐Zhi , Apaydin Nurdan M. , Ilki Alper , Catbas F. Necati 
Published: July 2020

SummaryThe effects of hanger replacement from inclined to vertical configuration on seismic response of long‐span suspension bridges are investigated considering multi‐support earthquake excitation. The Bosphorus Bridge is investigated due to its recent comprehensive rehabilitation, mainly involving hanger replacement. The finite‐fault stochastic simulation method (FINSIM) is utilized for multi‐point earthquake time‐history generation. The developed finite element (FE) model both for the inclined and vertical hanger arrangement are verified through the structural health monitoring (SHM) data. Based on the comparative analysis, the tension force of vertical hangers is found to be lower than that of inclined hangers, whereas the tension force of the main and back‐stay cables remains the same. The compressive axial force of the deck decreases relatively in the case of the vertical hanger arrangement, whereas the cross‐sectional forces at the tower base section increase. The approach viaducts are not affected by the vertical hanger arrangement. According to the demand/capacity ratios for damage estimation under the max. earthquake (2475 years return period), structural damage on the tower base section may be expected for both hanger arrangements, while these sections perform well under design scenario earthquake. The expansion joint of the bridge with inclined hangers is also estimated to be damaged; however, this displacement is lower in the case of the vertical hanger arrangement due to the viscous dampers. The findings also reveal that a change in hanger form of a suspension bridge can necessitate other structural retrofit, such as using viscous dampers to limit longitudinal displacements of the deck and retrofitting the bridge towers.
Sediment detachment in piping‐prone soils: Cohesion sources and potential weakening mechanisms
Authors: Bernatek‐Jakiel Anita , Bruthans Jiří , Vojtíšek Jan , Stolarczyk Mateusz , Zaleski Tomasz 
Published: July 2020

AbstractSoil piping is a widespread land degradation process that may lead to gully formation. However, the processes involved in sediment detachment from soil pipe walls have not been well studied, although their recognition is a crucial step to protect soils from piping erosion. This study aims to recognize the factors affecting cohesion and to identify the mechanisms which are likely to be responsible for the disintegration of soil. The study has been conducted in mid‐altitude mountains under a temperate climate (the Bieszczady Mountains, the Carpathians, SE Poland). The research was based on the detailed field and laboratory analyses of morphology, and the physical and chemical properties of soil profiles with and without soil pipes. Moreover, experiments with flooding the undisturbed soil samples using different solutions (deionized water, ammonium oxalate, dithionate citrate, 35% hydrochloric acid and 30% hydrogen peroxide) were conducted in order to check the role of air slaking, the removal of soil organic carbon (SOC), and Fe and Al oxides on sediment detachment. The obtained results have confirmed that soil pipes develop in quite cohesive soils (silt loams), which allow the formation and maintenance of pipes with a diameter up to 30 cm. Soil cohesion, and thus susceptibility to piping, are impacted by the content of major oxides, soil particle size distribution, biological activity and porosity. The tested soils affected by piping erosion have a lower content of Al2O3 and Fe2O3, and free Fe (Fe(DCB)), lower clay content, higher biological activity (more roots and animal burrows), higher porosity, and more and larger pores than the profile without soil pipes. The experiments have indicated that especially SOC along with Fe and Al oxides are an important cohesion source in the study area. This suggests that the removal of SOC, and Fe and Al oxides may weaken and disintegrate aggregates in soil pipes. Further study of soil leaching and tensile strength will broaden understanding of which chemical processes control where pipes will develop in other cohesive piping‐prone soils. © 2020 John Wiley & Sons, Ltd.
Formation of Fe‐embedded graphitic carbon network composites as anode materials for rechargeable Fe‐air batteries
Authors: Tan Wai Kian , Asami Kenta , Maegawa Keiichiro , Kawamura Go , Muto Hiroyuki , Matsuda Atsunori 
Published: July 2020

AbstractThis study reports on a composite consisting of iron (Fe) particles embedded in graphitic carbon network, which was prepared using a facile chemical synthesis method. The Fe‐embedded carbon composite was used as the anode material for Fe‐air batteries whose electrochemical charge‐discharge performance was subsequently evaluated. The effect of adding 0.01M Na2S to the batteries' alkaline electrolyte on the electrochemical performances of the Fe‐embedded carbon composite was investigated. The addition of Na2S to the electrolyte resulted in a higher discharge capacity during the charge‐discharge characterization. A maximum discharge capacity of 486 mAh g−1(Fe)was obtained because sulfide ions present in the electrolyte inhibited Fe passivation, thus enabling a better redox reaction. Interestingly, after prolonged charge‐discharge cycling (100 cycles), the replenishment of the 0.01M Na2S in the electrolyte resulted in the recovery of a high initial discharge capacity. The facile synthesis process, effect of Na2S addition, and the feasibility of discharge capacity recovery after prolonged charge‐discharge cycling reported in this study should be beneficial toward the further development of rechargeable Fe‐air batteries.
Application of a novel thermo‐sensitive injectable hydrogel in therapy in situ for drug accurate controlled release
Authors: Kong Xiaoying , Houzong Ruizhi , Fu Jun , Shao Kai , Wang Lili , Ma Yongchao , Shi Jinsheng 
Published: July 2020

AbstractLocal drug injection therapy for tumor site, as a neoadjuvant chemotherapy method, shows important significance in clinical application; however, it obtains unsatisfying therapeutic effect due to the serious toxic and side effect in normal tissues caused by drug diffusion or complexity of the preparation. In this article, the influence factors of the gelling time of traditional Chitosan (CTS) thermo‐sensitive hydrogels were analyzed, and the gelling properties were improved significantly, and a thermo‐sensitive hydrogel with precisely regulated gelling time was obtained through a green and simple preparation method, and the shortest gelling time (gelling time = 27 ± 2 s) of this hydrogel was 5% of that of the common CTS thermo‐sensitive hydrogels. After loaded with different chemotherapy drugs with different pH values (gemctiabin hydrochloride, levofloxacin, and 5‐foluorouracil), the hydrogels' gelling performance was not affected, while the gelling time could be shortened by 5‐foluorouracil, effectively hindering the drug loss at the early stage of sustained release. in vitro and in vivo experiments proved that precise encapsulation toward tumors with different volumes was achieved by the hydrogels, with minimal damage to surrounding normal tissues and higher utilization of drugs in tumor sites, ultimately achieving better tumor therapeutic effect. In conclusion, the new thermo‐sensitive hydrogels with precisely regulated gelling time showed great significance and potential for drug delivery and neoadjuvant chemotherapy.
Detection of submicroscopic chromosomal aberrations by chromosomal microarray analysis for the prenatal diagnosis of central nervous system abnormalities
Authors: Song Tingting , Xu Ying , Li Yu , Jia Li , Zheng Jiao , Dang Yinghui , Wan Shanning , Zheng Yunyun , Zhang Jianfang , Yang Hong 
Published: July 2020

AbstractBackgroundCentral nervous system (CNS) abnormalities are a group of serious birth defects associated with high rates of stillbirths, infant death, or abnormal development, and various disease‐causing copy number variations play a much more important role in the etiology of CNS abnormalities. This study intends to present a retrospective study of the prenatal diagnosis and the pregnancy outcome of fetuses diagnosed with CNS abnormalities, and evaluate the clinical value of chromosomal microarray analysis (CMA) in prenatal diagnosis of CNS abnormalities.MethodsA total of 356 fetuses with CNS abnormalities with or without other ultrasound abnormalities subjected to invasive prenatal diagnosis at the first affiliated hospital of Air Force Medical University from January 2015 to August 2018. All cases have performed both karyotyping and CMA concurrently, but 20 fetuses with chromosome aneuploidy were excluded in the current study.ResultsThe CMA identified pathogenic copy number variants (pCNVs) in 27/336 (8.03%) fetuses, likely pCNVs in 8/336 (2.38%) fetuses, and variants of unknown significance (VOUS) in 11/336 (3.27%) fetuses. A total of 222 cases had single CNS abnormalities and the pCNVs detection rate was 5.86% (13/222), the remaining 114 cases including CNS abnormalities plus other structural abnormalities, ultrasonographic soft markers and two or more CNS abnormalities, the pCNVs detection rate was 12.3% (14/114).ConclusionsFetuses with CNS abnormalities have a higher risk of chromosomal abnormalities, our study showed that CNVs play an important role in the etiology of CNS abnormalities. The application of CMA could increase the detection rate of pCNVs causing CNS abnormalities.
Classically activated mouse macrophages produce methylglyoxal that induces a TLR4- and RAGE-independent proinflammatory response
Authors: Prantner Daniel , Nallar Shreeram , Richard Katharina , Spiegel David , Collins Kim D , Vogel Stefanie N 
Published: July 2020

Abstract
The highly reactive compound methylglyoxal (MG) can cause direct damage to cells and tissues by reacting with cellular macromolecules. MG has been identified as a biomarker associated with increased sepsis-induced mortality. Patients undergoing septic shock have significantly elevated circulating MG levels compared to postoperative patients and healthy controls. Furthermore, MG has been implicated in the development of type II diabetes mellitus and Alzheimer’s disease. Because MG is generated during glycolysis, we hypothesized that MG may be produced by classically activated (M1) macrophages, possibly contributing to the inflammatory response. LPS and IFN-γ-treated macrophages acquired an M1 phenotype (as evidenced by M1 markers and enhanced glycolysis) and formed MG adducts, MG-H1, MG-H2, and MG-H3, which were detected using antibodies specific for MG-modified proteins (methylglyoxal 5-hydro-5-methylimidazolones). MG adducts were also increased in the lungs of LPS-treated mice. Macrophages treated with LPS and IFN-γ also exhibited decreased expression of glyoxalase 1 (Glo1), an enzyme that metabolizes MG. Concentrations of exogenous, purified MG &gt; 0.5 mM were toxic to macrophages; however, a nontoxic dose of 0.3 mM induced TNF-α and IL-1β, albeit to a lesser extent than LPS stimulation. Despite prior evidence that MG adducts may signal through “receptor for advanced glycation endproducts” (RAGE), MG-mediated cell death and cytokine induction by exogenous MG was RAGE-independent in primary macrophages. Finally, RAGE-deficient mice did not exhibit a significant survival advantage following lethal LPS injection. Overall, our evidence suggests that MG may be produced by M1 macrophages during sepsis, following IFN-γ-dependent down-regulation of Glo1, contributing to over-exuberant inflammation.
Stimuli‐Mild, Robust, Commercializable Polyurethane‐Urea Vitrimer Elastomer via N,N′‐Diaryl Urea Crosslinking
Authors: Zhang Dong , Chen Hongxiang , Dai Qiaoli , Xiang Chuanxi , Li Yanjun , Xiong Xiao , Zhou Yu , Zhang Jinlong 
Published: July 2020

AbstractVitrimer is a new reprocessable thermosetting polymer based on the exchange of dynamic covalent bonds. However, the vitrimer reported in the literatures can usually be reprocessed at very high temperature, while the vitrimer reprocessed at a relatively low temperature exhibits poor mechanical properties. It is still a great challenge to design mechanically robust vitrimer with a moderate reprocessing temperature. Herein, a polyurethane‐urea vitrimer elastomer including N,N′‐diaryl urea with electron donating effect is first reported, and it possesses a moderately remoldable temperature (100 °C, 23% of soft segments content) and robust mechanic al performance. The associative exchange mechanism of N,N′‐diaryl urea with electron donating effect is investigated by the stress relaxation, variable temperature Fourier transform infrared spectra of elastomer, as well as nuclear magnetic resonance spectra, and Fourier transform infrared spectra based on model compounds. Besides, for the preparation of polyurethane‐urea vitrimer elastomers, all monomers are directly from commercial raw materials, thereby providing a possibility of large‐scale production for the polyurethane‐urea vitrimers.
Broadband vertically interdigital‐capacitor with high frequency response improving
Authors: Zhou Bo , Li Changkun , Qian Li , Wang Yunheng , Zhang Ziyang 
Published: July 2020

AbstractA broadband vertically interdigital‐capacitor (VIC) is proposed and fabricated in a 10‐layer low temperature co‐fired ceramic substrate. By interconnecting the open ends of interval fingers, the number of stop‐band structures is reduced and thus the spurs that limit the bandwidth are removed. With the orthogonally placed input/output ports, the amplitudes of transmission coefficient and reflection coefficient are also improved. Thus, the high frequency response of VIC is improved. The bandwidth and capacitance of the proposed VIC increased 225% and 28%, respectively. The proposed VIC is available to make compact microwave components in a wider frequency rage. Comparison and discussion are provided as well.
Schizotypal and obsessive–compulsive traits: Co‐occurrence rate and relationship with executive function, emotion experience, and emotion expressivity in college students
Authors: Shan Hai‐di , Zhang Rui‐ting , Jiang Shu‐yao , Wang Yong‐ming , Liu Ya‐fei , Cheung Eric F. C. , Chan Raymond C. K. 
Published: July 2020

AbstractEmpirical findings suggest that there is an overlap between schizophrenia and obsessive–compulsive disorder (OCD). These disorders also have a high comorbidity rate. However, little is known about the impact of co‐occurring schizotypal and obsessive–compulsive traits on executive function, emotion experience, and emotion expressivity in the normal population. The present study examined the prevalence of coexisting schizotypal and obsessive–compulsive traits and the relationship between these two traits in a sample of healthy college students. We also conducted a moderation analysis to explore the effect of these two type of traits on executive function, emotion experience, and emotion expressivity. We recruited 3,319 participants to complete the Schizotypal Personality Questionnaire (SPQ) and the Obsessive–Compulsive Inventory – Revised (OCI‐R). A subset of them (n = 575) also completed the Chinese versions of the Dysexecutive Questionnaire (DEX), the Temporal Experience of Pleasure Scale (TEPS), and the Emotional Expressivity Scale (EES). We found that the prevalence of co‐occurring schizotypal and OCD traits was 3.33%. All the subscales of the SPQ and the OCI‐R significantly correlated with each other. Both traits had a negative impact on executive function and emotion expressivity. The interaction between the disorganization dimension of schizotypal traits and OCD traits had a significant effect on executive function, but not emotion experience or emotion expressivity. This study was limited by its cross‐sectional design and recruitment of only college students. These findings suggest that there is an approximately 3% rate of co‐occurring schizotypal and obsessive–compulsive traits in a healthy college student sample. The interaction between these two types of traits may influence executive function.
Nucleophilic fluoroalkylation as an efficient avenue to achieve fluorinated polyimide monomers containingCsp3‐Rffrom carbonyl compounds
Authors: Li Yongjian , Wang Zhongkai , Zhu Tangsong , Qi Haixia , Xiong Lei , Liu Feng 
Published: July 2020

AbstractFluorinated polyimides (PIs) have gained increasing attention due to their high transparency and low dielectric constant. However, the access to fluorinated monomers is limited, with most of the fluorination based on transformation from C─H to C─F. This article presents a new avenue to achieve fluorinated monomers starting from wide range of carbonyl compounds. Nucleophilic fluoroalkylation on carbonyl using Ruppert's reagent has been employed to transform carbonyl (CO) into α‐trifluoromethylated alcohol followed by facile derivation into diamine containing Csp3─CF3. The obtained symmetric fluorinated diamine para‐bis(1′‐[3‐amino‐6‐pyridinyloxy]‐1′‐trifluoromethyl)benzene (PAPyTB) show good modification effects on PIs. The PIs modified by PAPyTB exhibit the generally maintained optical transparency andTg. The mechanical properties of modified PIs show a wide range and decrease with increasing content of PAPyTB. Importantly, the solubility and hydrophobicity of the modified PIs increase with increasing loading of PAPyTB. Furthermore, the presence of trifluoromethyl groups in the polymer chain leads to reduced dielectric constant of the modified PIs, showing dielectric constant (ε′) 3.16 and dielectric loss (ε″) 0.0052 at 1 MHz and 298 K with 60% molar content of PAPyTB. This work indicates that nucleophilic fluoroalkylation is a new and efficient avenue to achieve fluorinated PI monomers with Csp3─Rffrom a wide range of carbonyl compounds.