bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of a Clinical Decision Support Tool to Manage Resistant Hypertension: Team-HTN, a Single-arm Pilot Study
Authors: Siaki Leilani A , LIN Victor , Marshall Robert , Highley Robert 
Published: October 2020

ABSTRACT

Introduction
Based on defining criteria, hypertension (HTN) affects 31% to 46% of the adult U.S. population and almost 20% of service members. Resistant HTN (rHTN) consumes significant resources, carries substantial morbidity and mortality risk and costs over $350 billion dollars annually. For multiple reasons, only 48.3% of people with HTN are controlled, e.g., undiagnosed secondary HTN, therapeutic or diagnostic inertia, and patient adherence. Our purpose was to determine the feasibility of a web-based clinical decision support tool (CDST) using a renin-aldosterone system (RAS) classification matrix and drug sequencing algorithm to assist providers with the diagnosis and management of uncontrolled HTN (rHTN). Outcomes were blood pressure (BP) rates of control, provider management time, and end-user satisfaction.

Methods
This two-phase, prospective, non-randomized, single-arm, six-month pilot study was conducted in primary care clinics at a tertiary military medical center. Patients with uncontrolled HTN and primary care providers were recruited. Phase 1 patients checked their BP twice daily (AM and PM), three times weekly using a standardized arm cuff. Patients with rHTN were enrolled in phase 2. Phase 2 patients were managed virtually by providers using the CDST, the RAS classification matrix, and the drug sequencing algorithm which incorporated age, ethnicity, comorbidities, and renin/aldosterone levels. Medications were adjusted every 10 days until BP was at target, using virtual visits.

Results
In total, 54 patients and 16 providers were consented. One transplant patient was disqualified, 29 met phase 2 criteria for rHTN, and 6 providers completed the study. In phase 1, 45% (n = 24) of patients were identified as having apparent uncontrolled HTN using peak diurnal blood pressure (pdBP) home readings. In phase 2 (n = 29), previously undetected RAS abnormalities were identified in 69% (n = 20) of patients. Blood pressure control rates improved from 0% to 23%, 47%, and 58% at 2, 4, and 6 months, respectively. Provider management time was reduced by 17%. Using home pdBP readings identified masked HTN in almost 20% of patients that would have been missed by a single daily AM or PM home BP measurement. Feasibility and satisfaction trends were favorable.

Conclusions
Despite significant morbidity, mortality, and existing guidelines, over half of hypertensive patients are uncontrolled. Our results suggest that this CDST used with pdBP monitoring is a feasible option to facilitate improved rates of control in rHTN, aid in overcoming therapeutic/diagnostic inertia, improve identification of secondary HTN, and potentially, access. Further research with this tool in a larger population is recommended.
Oral Health Status Among Adults With and Without Prior Active Duty Service in the U.S. Armed Forces, NHANES 2011-2014
Authors: Schindler David K , Lopez Mitnik Gabriela V , Soliván-Ortiz Aida M , Irwin Scott P , Boroumand Shahdokht , Dye Bruce A 
Published: October 2020

ABSTRACT

Introduction
Many veterans qualify for health benefits but generally not dental care. This study examines differences in oral health status between veterans and nonveterans in the U.S. to determine how various factors, including socioeconomic, general health, and tobacco use, impact former service members’ oral health.

Materials and Methods
Data from 11,539 dentate adults participating in the National Health and Nutrition Examination Survey (2011-2014) were used. Outcome variables included decayed teeth (DT), missing teeth (MT), filled teeth (FT), caries experience (DMFT), and periodontitis (PD). Covariates included demographic and socioeconomic factors, deployment, smoking, depression, hypertension, hyperlipidemia, and diabetes. Logistic regression modelling was used to assess associations between these factors and oral health outcomes.

Results
Veterans represent about 9% of the U.S. population. There was a higher prevalence of PD, MT, FT, and DMFT among veterans than nonveterans. Veterans were more likely to have PD (OR, 1.8; 95% CI, 1.3 to 2.5) and higher DMFT (OR, 2.9; 95% CI, 2.4 to 3.4); however, after controlling for other covariates, military service was only associated with FT (OR, 1.3; 95% CI, 1.1 to 1.6) and higher DMFT (OR, 1.6; 95% CI, 1.2 to 1.9).

Conclusions
Because veterans are more likely to originate from groups at a higher risk for poor oral health (older adults, smokers, males, diabetics), the prevalence of adverse oral health conditions are higher among veterans compared to nonveterans. Overall, military service is not associated with PD or untreated dental caries but is associated with indicators suggesting veterans have had more dental treatment (FT and DMFT). There is substantial unmet oral health care need primarily related to periodontitis among veterans.
The absolute magnitudes MJ, the binary fraction, and the binary mass ratios of M7–M9.5 dwarfs
Authors: Laithwaite R C , Warren S J 
Published: October 2020

ABSTRACT
We use the large homogeneous sample of late M dwarfs, M7–M9.5, of Ahmed & Warren (2019) matched to Gaia DR2, to measure the relation between absolute magnitude and spectral type, and to infer the multiplicity fraction of the population, and the distribution of mass ratios in the binary systems. Binaries are identified photometrically as overluminous sources. In order to define a sample that is unbiased with respect to multiplicity we use distance limits that are a function of G − J colour to define a volume-complete sample of 2706 systems. The G − J colours are very precise, with random errors all less than 0.02. We measure absolute magnitudes MJ that are on average 0.5 mag brighter than previous determinations. We find evidence that the discrepancies arise from differences in spectral types in different samples. The measured binary fraction is $16.5\pm 0.8{{\ \rm per\ cent}}$, of which $98{{\ \rm per\ cent}}$ are unresolved: both values are consistent with results of previous studies. The distribution of excess flux in the binaries, compared to the singles, is used to infer the mass ratio distribution f(q)∝qγ, where q = Ms/Mp. We infer a very steep distribution over this spectral range, with γ &gt; 10 ($99{{\ \rm per\ cent}}$ probability). This says that unresolved ultracool M dwarf binaries reside almost exclusively in equal mass systems, and implies that the spectral types of the unresolved binaries match to with 0.5 spectral subtypes. The intrinsic scatter in absolute magnitude MJ for ultracool M dwarfs at fixed G − J colour is measured to be 0.21 mag.
The number of globular clusters around the iconic UDG DF44 is as expected for dwarf galaxies
Authors: Saifollahi Teymoor , Trujillo Ignacio , Beasley Michael A , Peletier Reynier F , Knapen Johan H 
Published: October 2020

ABSTRACT
There is a growing consensus that the vast majority of ultradiffuse galaxies (UDGs) are dwarf galaxies. However, there remain a few UDGs that seem to be special in terms of their globular cluster (GC) systems. In particular, according to some authors, certain UDGs exhibit large GC populations when compared to expectations from their stellar (or total) mass. Among these special UDGs, DF44 in the Coma cluster is one of the better-known examples. DF44 has been claimed to have a relatively high number of GCs, $N_{\mathrm{ GC}}=74^{+18}_{-18}$, for a stellar mass of only $3\times 10^8\, \mathrm{ M}_{ \odot}$ which would indicate a much larger dark halo mass than dwarfs of similar stellar mass. In this paper, we revisit this number and, contrary to previous results, find $N_{\mathrm{ GC}}=21^{+7}_{-9}$ assuming that the distribution of the GCs follows the same geometry as the galaxy. If we assume that the GCs around DF44 are distributed in a (projected) circularly symmetric way and, if we use a less strict criterion for the selection of the GCs, we find $N_{\mathrm{ GC}}=18^{+23}_{-12}$. Making use of the MGC–Mhalo relation, this number of GCs suggests a dark matter halo mass of $M_{\mathrm{ halo}}=1.1^{+0.4}_{-0.5} \times 10^{11} \mathrm{ M}_{\odot}$, a value which is consistent with the expected total mass for DF44 based on its velocity dispersion, $\sigma =33^{+3}_{-3}$ km s−1. We conclude that the number of GCs around DF44 is as expected for regular dwarf galaxies of similar stellar mass and DF44 is not extraordinary in this respect.
The Nucleome Data Bank: web-based resources to simulate and analyze the three-dimensional genome
Authors: Contessoto Vinícius G , Cheng Ryan R , Hajitaheri Arya , Dodero-Rojas Esteban , Mello Matheus F , Lieberman-Aiden Erez , Wolynes Peter G , Di Pierro Michele , Onuchic José N 
Published: October 2020

AbstractWe introduce the Nucleome Data Bank (NDB), a web-based platform to simulate and analyze the three-dimensional (3D) organization of genomes. The NDB enables physics-based simulation of chromosomal structural dynamics through the MEGABASE + MiChroM computational pipeline. The input of the pipeline consists of epigenetic information sourced from the Encode database; the output consists of the trajectories of chromosomal motions that accurately predict Hi-C and fluorescence insitu hybridization data, as well as multiple observations of chromosomal dynamics in vivo. As an intermediate step, users can also generate chromosomal sub-compartment annotations directly from the same epigenetic input, without the use of any DNA–DNA proximity ligation data. Additionally, the NDB freely hosts both experimental and computational structural genomics data. Besides being able to perform their own genome simulations and download the hosted data, users can also analyze and visualize the same data through custom-designed web-based tools. In particular, the one-dimensional genetic and epigenetic data can be overlaid onto accurate 3D structures of chromosomes, to study the spatial distribution of genetic and epigenetic features. The NDB aims to be a shared resource to biologists, biophysicists and all genome scientists. The NDB is available at https://ndb.rice.edu.
Understanding DNA interactions in crowded environments with a coarse-grained model
Authors: Hong Fan , Schreck John S , Šulc Petr 
Published: October 2020

AbstractNucleic acid interactions under crowded environments are of great importance for biological processes and nanotechnology. However, the kinetics and thermodynamics of nucleic acid interactions in a crowded environment remain poorly understood. We use a coarse-grained model of DNA to study the kinetics and thermodynamics of DNA duplex and hairpin formation in crowded environments. We find that crowders can increase the melting temperature of both an 8-mer DNA duplex and a hairpin with a stem of 6-nt depending on the excluded volume fraction of crowders in solution and the crowder size. The crowding induced stability originates from the entropic effect caused by the crowding particles in the system. Additionally, we study the hybridization kinetics of DNA duplex formation and the formation of hairpin stems, finding that the reaction rate kon is increased by the crowding effect, while koff is changed only moderately. The increase in kon mostly comes from increasing the probability of reaching a transition state with one base pair formed. A DNA strand displacement reaction in a crowded environment is also studied with the model and we find that rate of toehold association is increased, with possible applications to speeding up strand displacement cascades in nucleic acid nanotechnology.
Chewie Nomenclature Server (chewie-NS): a deployable nomenclature server for easy sharing of core and whole genome MLST schemas
Authors: Mamede Rafael , Vila-Cerqueira Pedro , Silva Mickael , Carriço João A , Ramirez Mário 
Published: October 2020

Abstract
Chewie Nomenclature Server (chewie-NS, https://chewbbaca.online/) allows users to share genome-based gene-by-gene typing schemas and to maintain a common nomenclature, simplifying the comparison of results. The combination between local analyses and a public repository of allelic data strikes a balance between potential confidentiality issues and the need to compare results. The possibility of deploying private instances of chewie-NS facilitates the creation of nomenclature servers with a restricted user base to allow compliance with the strictest data policies. Chewie-NS allows users to easily share their own schemas and to explore publicly available schemas, including informative statistics on schemas and loci presented in interactive charts and tables. Users can retrieve all the information necessary to run a schema locally or all the alleles identified at a particular locus. The integration with the chewBBACA suite enables users to directly upload new schemas to chewie-NS, download existing schemas and synchronize local and remote schemas from chewBBACA command line version, allowing an easier integration into high-throughput analysis pipelines. The same REST API linking chewie-NS and the chewBBACA suite supports the interaction of other interfaces or pipelines with the databases available at chewie-NS, facilitating the reusability of the stored data.
Low-Dose Intravenous Heparin Infusion After Aneurysmal Subarachnoid Hemorrhage is Associated With Decreased Risk of Delayed Neurological Deficit and Cerebral Infarction
Authors: Kole Matthew J , Wessell Aaron P , Ugiliweneza Beatrice , Cannarsa Gregory J , Fortuny Enzo , Stokum Jesse A , Shea Phelan , Chryssikos Timothy , Khattar Nicolas K , Crabill George A , Schreibman David L , Badjatia Neeraj , Gandhi Dheeraj , Aldrich E Francois , James Robert F , Simard J Marc 
Published: October 2020

Abstract

BACKGROUND
Patients who survive aneurysmal subarachnoid hemorrhage (aSAH) are at risk for delayed neurological deficits (DND) and cerebral infarction. In this exploratory cohort comparison analysis, we compared in-hospital outcomes of aSAH patients administered a low-dose intravenous heparin (LDIVH) infusion (12 U/kg/h) vs those administered standard subcutaneous heparin (SQH) prophylaxis for deep vein thrombosis (DVT; 5000 U, 3 × daily).

OBJECTIVE
To assess the safety and efficacy of LDIVH in aSAH patients.

METHODS
We retrospectively analyzed 556 consecutive cases of aSAH patients whose aneurysm was secured by clipping or coiling at a single institution over a 10-yr period, including 233 administered the LDIVH protocol and 323 administered the SQH protocol. Radiological and outcome data were compared between the 2 cohorts using multivariable logistic regression and propensity score-based inverse probability of treatment weighting (IPTW).

RESULTS
The unadjusted rate of cerebral infarction in the LDIVH cohort was half that in SQH cohort (9 vs 18%; P = .004). Multivariable logistic regression showed that patients in the LDIVH cohort were significantly less likely than those in the SQH cohort to have DND (odds ratio (OR) 0.53 [95% CI: 0.33, 0.85]) or cerebral infarction (OR 0.40 [95% CI: 0.23, 0.71]). Analysis following IPTW showed similar results. Rates of hemorrhagic complications, heparin-induced thrombocytopenia and DVT were not different between cohorts.

CONCLUSION
This cohort comparison analysis suggests that LDIVH infusion may favorably influence the outcome of patients after aSAH. Prospective studies are required to further assess the benefit of LDIVH infusion in patients with aSAH.
Associations Between Family and Peer E-Cigarette Use With Adolescent Tobacco and Marijuana Usage: A Longitudinal Path Analytic Approach
Authors: Coleman Michael , Donaldson Candice D , Crano William D , Pike James R , Stacy Alan W 
Published: October 2020

AbstractIntroductionResearch indicates a link between adolescent e-cigarette use and combustible tobacco cigarette (CTC) initiation, and recent studies suggest their connection with marijuana uptake. Our 3-year longitudinal cohort study investigated the implications of adolescent, peer, and family e-cigarette use with adolescents’ expectations and willingness to initiate CTC use, and subsequent CTC and marijuana use.Aims and MethodsRelationships were examined in a secondary analysis of a 3-year longitudinal cohort subsample involving adolescents enrolled in alternative California high schools (N = 1025). Analyses examined responses over three yearly observations. Family, peer, and respondents’ e-cigarette use, respondents’ positive cigarette expectancies and willingness to use CTCs were assessed in the study’s first year (T1). CTC use in the survey’s second year (T2) and marijuana use in the third year (T3) were assessed via path analysis.ResultsRespondents reporting at least one family member or peer using e-cigarettes were more likely to use e-cigarettes at T1 than those whose peers/family members did not. They reported more positive expectancies about CTCs and greater willingness to initiate use. These variables predicted CTC use at T2, which directly anticipated marijuana use in the survey’s third year (T3), as did adolescents’ use of e-cigarettes at T1. All model relations were statistically significant.ConclusionsAnalysis demonstrated the strong association of family members’ and peers’ behaviors with adolescent e-cigarette use, and the temporal precedence of e-cigarette use with subsequent CTC and marijuana uptake. The predictive implications of e-cigarettes for other dangerous substance use should be examined in future prevention campaigns.ImplicationsThe presented study expands upon existing literature connecting adolescent e-cigarette use and later CTC and marijuana use. The findings indicate the significant implications of exposure to e-cigarette use by parents and peers and demonstrate in a longitudinal 4-year panel survey the direct and indirect predictive implications of e-cigarette use for CTC and marijuana uptake. The research illustrates the utility of programs and campaigns that target peer and family groups to maximize impacts on adolescent willingness to try CTCs, positive expectancies, and possible onset of CTC and marijuana use.
The Impact of COVID-19 on Smoking Patterns in Pakistan: Findings From a Longitudinal Survey of Smokers
Authors: Siddiqi Kamran , Siddiqui Faraz , Khan Amina , Ansaari Saeed , Kanaan Mona , Khokhar Mariam , Islam Ziauddin , Mishu Masuma Pervin , Bauld Linda 
Published: October 2020

Abstract

Introduction
We investigated the influence of COVID-19 on smoking patterns in Pakistan.

Methods
In a longitudinal survey, we asked cigarette smokers in Pakistan about their smoking behaviors before and since COVID-19. Smokers were recruited before COVID-19 using two-stage random probability sampling. Since COVID-19, three subsequent waves were conducted over the telephone, asking additional questions on social determinants, mental health, and well-being. Based on the first two waves, we estimated the proportion of smokers who stopped, decreased, maintained, or increased smoking. We also explored any factors associated with the change in smoking patterns. In those who stopped smoking soon after COVID-19, we estimated the proportion relapsed in subsequent waves. We estimated all proportions based on complete-case analysis.

Results
We recruited 6014 smokers between September 2019 and February 2020; of these, 2087 (2062 reported smoking outcomes) were followed up in May 2020 after COVID-19. Since COVID-19, 14% (290/2062) smokers reported quitting. Among those who continued smoking: 68% (1210/1772) reduced, 14% (239/1772) maintained, and 18% (323/1772) increased cigarette consumption; 37% (351/938) reported at least one quit attempt; 41% (669/1619) were more motivated; while 21% (333/1619) were less motivated to quit. Changes in smoking patterns varied with nicotine dependence, motivation to quit, and financial stability since COVID-19. Among those reporting quitting soon after COVID-19, 39% (81/206) relapsed in the subsequent months (June–July 2020).

Conclusions
There have been significant bidirectional changes in smoking patterns since COVID-19 in Pakistan. Although many people stopped, reduced, or tried quitting smoking, some increased smoking and some relapsed after quitting.

Implications
We observed significant and complex changes in people’s smoking patterns, which are likely to be attributable to the COVID-19 pandemic and replicated in similar events in the future. Assessing these changes is essential for most low- and middle-income countries like Pakistan, where the vast majority of tobacco users live, but cessation support is still rudimentary. If provided routinely, smoking cessation interventions can potentially support millions of highly motivated individuals in quitting successfully both in general and in global events like COVID-19, in particular.
Hormonal Diterpenoids Distinct to Gibberellins Regulate Protonema Differentiation in the Moss Physcomitrium patens
Authors: Nakajima Masatoshi , Miyazaki Sho , Kawaide Hiroshi 
Published: October 2020

Abstract
Plants synthesize gibberellin (GA), a diterpenoid hormone, via ent-kaurenoic acid (KA) oxidation. GA has not been detected in the moss Physcomitrium patens despite its ability to synthesize KA. It was recently shown that a KA metabolite, 3OH-KA, was identified as an active regulator of protonema differentiation in P. patens. An inactive KA metabolite, 2OH-KA, was also identified in the moss, as was KA2ox, which is responsible for converting KA to 2OH-KA. In this review, we mainly discuss the GA biosynthetic gene homologs identified and characterized in bryophytes. We show the similarities and differences between the OH-KA control of moss and GA control of flowering plants. We also discuss using recent genomic studies; mosses do not contain KAO, even though other bryophytes do. This absence of KAO in mosses corresponds to the presence of KA2ox, which is absent in other vascular plants. Thus, given that 2OH-KA and 3OH-KA were isolated from ferns and flowering plants, respectively, vascular plants may have evolved from ancestral bryophytes that originally produced 3OH-KA and GA.
Dissociative and Analgesic Properties of Ketamine Are Independent
Authors: Gitlin Jacob , Chamadia Shubham , Locascio Joseph J. , Ethridge Breanna R. , Pedemonte Juan C. , Hahm Eunice Y. , Ibala Reine , Mekonnen Jennifer , Colon Katia M. , Qu Jason , Akeju Oluwaseun 
Published: October 2020

Background
Ketamine is a dissociative anesthetic with analgesic properties. Ketamine’s analgesic properties have been suggested to result from its dissociative properties. To the authors’ knowledge, this postulate is unsubstantiated. The authors hypothesize that the dissociative and analgesic properties of ketamine are independent.

Methods
The authors conducted a single-site, open-label study of ketamine anesthesia (2 mg/kg) in 15 healthy subjects. Midazolam was administered at a prespecified time point to attenuate dissociation. The authors longitudinally assessed precalibrated cuff pain intensity and quality using Patient-Reported Outcomes Measurement Information System questionnaires, and dissociation, using the Clinician Administered Dissociative States Scale. Mixed effects models were used to assess whether dissociation accounted for the effect of ketamine on pain intensity and quality.

Results
The dissociation model demonstrated an inverted U-shaped quadratic relationship between time and dissociation scores. Additive to this effect, midazolam reduced the dissociation adjusted means by 10.3 points (95% CI, 3.4 to 17.1; P = 0.005). The pain intensity model also demonstrated a U-shaped quadratic relationship between time and pain intensity. When the pain intensity model was reanalyzed with dissociation scores as an additional covariate, the dissociation term was not retained in the model, and the other effects were preserved in direction and strength. This result was conserved for nociceptive and neuropathic pain quality.

Conclusions
Ketamine’s analgesic properties are not exclusively caused by dissociation. Thus, ketamine may be used as a probe to advance our knowledge of dissociation independent neural circuits that encode pain.

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