bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic analysis of remaining oil in thin and poor layers in Lamadian oilfield
Authors: Liu Wenchao 
Published: April 2020

Abstract
Understanding the distribution of remaining oil and its genesis is the basic work of geological research. Lamadian oilfield has entered the late development stage of ultra-high water cut, the thick oil layer of water drive is decreasing gradually, and the thin and poor oil layer is becoming an important target of adjustment and tapping potential below 1.0m. In order to further improve the development effect of thin and poor reservoir, it is necessary to analyze the saturation field of the numerical model based on interpretation result, core analysis result of sealed coring well and water drive model. The remaining oil characteristics of thin and poor reservoir are studied by means of statistics, genetic analysis, dynamic analysis and static analysis.
State of Health Estimation Framework of Li-on Battery Based on Improved Gaussian Process Regression for Real Car Data
Authors: Xiao Wei , Xu Huachi , Jia Jun , Feng Fei , Wang Wen 
Published: April 2020

Abstract
With the diversification of power batteries in the market, the estimation and management of State of Health (SOH) become more and more important. The building of the models based on experimental data needs much time and many resources, and the models do not have strong versatility. In this paper, a data-driven on-line SOH estimation framework is built by using the measured data of vehicle operating process. In case that the charging data is incomplete and with low precision, an indirect feature (IF) extraction and combination scheme based on Incremental Capacity Analysis (ICA) is built, so as to realize the mapping between IF and SOH based on Gaussian Process Regression (GPR), and Multi-Colony Particle Swarm Optimization (MPSO) is adopted to solve the local optimum of GPR hyper-parameters. Finally, after the algorithm is verified and evaluated by applying NASA (National Aeronautics and Space Administration) dataset and real vehicle data, and when the training amount of operation data is enough, the error of SOH estimation can be controlled within 2%, which shows that the algorithm has good versatility and estimation precision.
Functional preservation and enhanced capacity for visual restoration in subacute occipital stroke
Authors: Saionz Elizabeth L , Tadin Duje , Melnick Michael D , Huxlin Krystel R 
Published: April 2020

Abstract
Stroke damage to the primary visual cortex (V1) causes a loss of vision known as hemianopia or cortically-induced blindness. While perimetric visual field improvements can occur spontaneously in the first few months post-stroke, by 6 months post-stroke, the deficit is considered chronic and permanent. Despite evidence from sensorimotor stroke showing that early injury responses heighten neuroplastic potential, to date, visual rehabilitation research has focused on patients with chronic cortically-induced blindness. Consequently, little is known about the functional properties of the post-stroke visual system in the subacute period, nor do we know if these properties can be harnessed to enhance visual recovery. Here, for the first time, we show that ‘conscious’ visual discrimination abilities are often preserved inside subacute, perimetrically-defined blind fields, but they disappear by ∼6 months post-stroke. Complementing this discovery, we now show that training initiated subacutely can recover global motion discrimination and integration, as well as luminance detection perimetry, just as it does in chronic cortically-induced blindness. However, subacute recovery was attained six times faster; it also generalized to deeper, untrained regions of the blind field, and to other (untrained) aspects of motion perception, preventing their degradation upon reaching the chronic period. In contrast, untrained subacutes exhibited spontaneous improvements in luminance detection perimetry, but spontaneous recovery of motion discriminations was never observed. Thus, in cortically-induced blindness, the early post-stroke period appears characterized by gradual—rather than sudden—loss of visual processing. Subacute training stops this degradation, and is far more efficient at eliciting recovery than identical training in the chronic period. Finally, spontaneous visual improvements in subacutes were restricted to luminance detection; discrimination abilities only recovered following deliberate training. Our findings suggest that after V1 damage, rather than waiting for vision to stabilize, early training interventions may be key to maximize the system’s potential for recovery.
Genotype–immunophenotype analysis reveals the immunogenomic subtype and prognosis of multiple myeloma
Authors: Wang Yue , Feng Wanjing , Liu Peng 
Published: April 2020

Abstract
Immune dysfunction plays an important role in tumour development, recurrence, therapeutic responses and overall survival (OS). Multiple myeloma (MM) is a clonal B-cell malignancy which characterized by anti-tumoural immune dysfunction. In this study, we analysed 28 tumour-immune-related pathways and calculated the immune pathway score through published microarray data from the Gene Expression Omnibus (GEO) data portal. A training set of 345 patients and a validation set of 214 patients with primary MM were chosen. We performed least absolute shrinkage and selection operator (LASSO) analysis to identify prognostic factors. Then, we used cluster analysis to divide patients into three immunogenomic subtypes, which named abnormal immune activated type, common type and anti-myeloma immune activated type. Log‑rank tests showed that anti-myeloma immune activated type had the best prognosis and abnormal immune activated type had the shortest OS (P = 0.000) and event-free survival (EFS) (P = 0.000). Multivariate Cox also indicated that the immunogenomic subtype was an independent predictor of OS (P = 0.001) and EFS (P = 0.000). We also analysed the characteristics and the immune-response patterns of different subtypes. Then, we established a mathematical model to classify patients in the validation set. In the validation set, patients with different immunogenomic subtypes also had a significantly different OS (P = 0.001) and EFS (P = 0.005). Our study explored tumour-immune-related pathways at a multi-dimensional level and found the immunogenomic subtype of MM. Potential mechanisms on the genetic level of how tumour-immunity influences the prognosis and therapeutic responses are provided. The immunogenomic subtype may be feasible for deciding clinical treatment in the future.
Prevalence, Predictors, and Severity of Lean Nonalcoholic Fatty Liver Disease in Patients Living With Human Immunodeficiency Virus
Authors: Cervo Adriana , Milic Jovana , Mazzola Giovanni , Schepis Filippo , Petta Salvatore , Krahn Thomas , Lebouche Bertrand , Deschenes Marc , Cascio Antonio , Guaraldi Giovanni , Sebastiani Giada 
Published: April 2020

Abstract

Background
The burden of nonalcoholic fatty liver disease (NAFLD) is growing in people living with human immunodeficiency virus (HIV). NAFLD is associated with obesity; however, it can occur in normoweight (lean) patients. We aimed to investigate lean NAFLD in patients living with HIV.

Methods
We included patients living with HIV mono-infection from 3 prospective cohorts. NAFLD was diagnosed by transient elastography (TE) and defined as controlled attenuation parameter ≥248 dB/m, in absence of alcohol abuse. Lean NAFLD was defined when a body mass index was &lt;25 kg/m2. Significant liver fibrosis was defined as TE ≥7.1 kPa. The presence of diabetes, hypertension, or hyperlipidemia defined metabolically abnormal patients.

Results
We included 1511 patients, of whom 57.4% were lean. The prevalence of lean NAFLD patients in the whole cohort was 13.9%. NAFLD affected 24.2% of lean patients. The proportions of lean NAFLD patients who were metabolically abnormal or had elevated alanine aminotransferase (ALT) were higher than among those who were lean patients without NAFLD (61.9% vs 48.9% and 36.7% vs 24.2%, respectively). Lean NAFLD patients had a higher prevalence of significant liver fibrosis than lean patients without NAFLD (15.7% vs 7.6%, respectively). After adjusting for sex, ethnicity, hypertension, CD4 cell count, nadir CD4 &lt;200µ/L, and time since HIV diagnosis, predictors of NAFLD in lean patients were age (adjusted OR [aOR], 1.29; 95% confidence interval [CI], 1.04–1.59), high triglycerides (aOR, 1.34; 95% CI, 1.11–1.63), and high ALT (aOR, 1.15; 95% CI, 1.05–1.26), while a high level of high-density lipoprotein cholesterol was protective (aOR, 0.45; 95% CI, .26–.77).

Conclusions
NAFLD affects 1 in 4 lean patients living with HIV mono-infection. Investigations for NAFLD should be proposed in older patients with dyslipidemia and elevated ALT, even if normoweight.
The VACCINES Act: Deciphering Vaccine Hesitancy in the Time of COVID-19
Authors: McAteer John , Yildirim Inci , Chahroudi Ann 
Published: April 2020

Abstract
Since the COVID-19 pandemic first hit Wuhan, China, in December 2019, scientists have been racing to develop and test novel vaccines to protect against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The speed of scientific discovery related to COVID-19 is unprecedented. With several vaccine candidates already being tested in clinical trials, we pose the question: what will the vaccine hesitant do in the face of this pandemic?
Triggering relationships between magmatic and faulting processes in the May 2018 eruptive sequence at Kīlauea volcano, Hawaii
Authors: Kundu Bhaskar , Yadav Rajeev Kumar , Bürgmann Roland , Wang Kang , Panda Dibyashakti , Gahalaut Vineet K 
Published: April 2020

SUMMARYThe May 2018 activity at Kīlauea Volcano, Hawaii involved magma transport and dyke intrusion along the East Rift Zone (ERZ) and nucleation of the 4 May 2018 M 6.9 earthquake along the basal décollement of Kīlauea's mobile south flank. Combined Global Positioning Systems (GPS) and Interferometric Synthetic Aperture Radar (InSAR) measurements captured the deformation sequence associated with the dyke intrusion, main shock and eruption episode along the ERZ. The earthquake was encouraged by static stress changes from the preceding magma reservoir inflation, ERZ expansion and fault creep on the décollement downdip of the rupture. Slip models derived from the inversion of GPS displacements indicate peak coseismic slip of 2–3 m. Our model analyses, including of the pre-May 2018 deformation, suggest that prior to this event there was no slip on the section of the décollement that ruptured in the earthquake. The observed magma inflation, rapid fault creep on the décollement and coseismic rupture reflect complex cyclic interactions between the magmatic and faulting processes.
Response of Male Queensland Fruit Fly (Diptera: Tephritidae) to Host Fruit Odors
Authors: Tasnin Mst Shahrima , Silva Rehan , Merkel Katharina , Clarke Anthony R 
Published: April 2020

AbstractThe surveillance and management of Dacini fruit fly pests are commonly split by fly gender: male trapping focuses on the dacine ‘male-lures’, whereas female trapping focuses on lures based on host-fruit volatiles. Although the males of several Dacini species have been reported to be attracted to host fruit volatiles, the option of using host-fruit traps for males has, to date, been ignored. Males of the cue-lure responsive fruit fly Bactrocera tryoni (Froggatt) have been recorded as responding to host-fruit volatile blends, but it is not known how frequently this happens, if it is age-dependent, or the strength of the response relative to cue-lure throughout the year. Here, we conducted an olfactometer experiment to test the lifetime (weeks 1–15) response of B. tryoni males to the odor of tomato, a known host of this fly, and compare catches of wild males to tomato-based traps and cue-lure traps in the field. Bactrocera tryoni males started to respond to tomato odor as they sexually matured (2 to 3 wk olds) and thereafter showed consistent olfactory response until advanced age (15 wk). In the field, wild males were captured by tomato-based traps throughout the year at a level not significantly different from cue-lure traps. The reason for the consistent B. tryoni male response to host fruit odor at this stage is not known, but it certainly occurs at a level greater than can be continued to be ignored for both basic and applied research.
Pathological Tumor Response Following Immune Checkpoint Blockade for Deficient Mismatch Repair Advanced Colorectal Cancer
Authors: Ludford Kaysia , Cohen Romain , Svrcek Magali , Foo Wai Chin , Colle Raphael , Parc Yann , Thomas Jane Varkey , Morris Van Karlyle , Kopetz Scott , Chang George J , Overman Michael , Andre Thierry 
Published: April 2020

Abstract
Immune checkpoint inhibition (CPI) for metastatic colorectal cancer (mCRC) with deficient mismatch repair (dMMR) demonstrates high clinical activity that appears durable, but the impact of CPI on pathological tumor response is unknown. In this retrospective analysis, our objective was to assess pathological response and clinical outcomes in dMMR mCRC patients treated with CPI prior to surgical resection of primary and/or metastatic tumor. Among 121 advanced dMMR mCRC patients treated with CPI at 2 institutions between November 2016 and December 2018, 14 underwent surgery. Pathologic complete response was noted in the resected specimens of 13 patients despite the presence of residual tumor on preoperative imaging in 12 of those patients. With median follow-up of 9 months, no patients have had disease relapse or progression. For this small retrospective study, the data suggest that residual radiographic tumor may not require systematic resection following response to anti-PD1–based therapy. However, larger prospective studies are warranted.
Home Health Use Following a Cancer Diagnosis Among Patients Enrolled in Medicare Advantage and Traditional Medicare: Findings From the Newly Linked SEER-Medicare and Home Health OASIS Data
Authors: Thomas Kali S , Schwartz Margot L , Boyd Eric , White Dolly P , Mariotto Angela B , Barrett Michael J , Warren Joan L 
Published: April 2020

Abstract

Background
This article describes characteristics of patients receiving home health following an initial cancer diagnosis, comparing those enrolled in Medicare Advantage (MA) and Traditional Medicare (TM), using the newly linked 2010–2014 National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER)-Medicare and home health Outcome and Assessment Information Set (OASIS) data.

Methods
We identified SEER-Medicare beneficiaries with at least one OASIS assessment within 3 months of cancer diagnosis in 2010-2014, and summarized their demographic and clinical characteristics. Demographic and diagnostic data were obtained from the SEER-Medicare data, while further details about cognitive status, mood, function, and medical history were obtained from OASIS. We assessed differences between MA and TM beneficiaries using chi-square tests for independence, t-tests, and Kruskal-Wallis tests.

Resutls
We identified 104 023 patients who received home health within 3 months of cancer diagnosis: 81 587 enrolled in TM and 22 436 enrolled in MA. TM cancer patients had higher unadjusted rates of home health use than MA patients (16.3% vs 10.3%, P &lt; .001). TM cancer patients receiving home health had more limitations in their cognitive function than their MA counterparts and longer lengths of service (mean = 42.2 days vs 39.4 days, P &lt; .001; median = 27 vs 26 days, interquartile range = 42).

Conclusion
This study demonstrates the large number of cancer patients in the SEER-Medicare-OASIS data and describes characteristics for TM and MA patients. These newly linked data can be used to assess home health care among older patients with cancer.
Cigarette Use, E-Cigarette Use, and Dual Product Use Are Higher Among Adults With Serious Psychological Distress in the United States: 2014–2017
Authors: Weinberger Andrea H , Zhu Jiaqi , Barrington-Trimis Jessica L , Wyka Katarzyna , Goodwin Renee D 
Published: April 2020

AbstractIntroductionCigarette use is declining yet remains common among adults with mental health conditions. In contrast, e-cigarette use may be on the rise. This study investigated the relationship between serious psychological distress (SPD) and the exclusive and dual use of cigarettes and e-cigarettes among US adults from 2014 to 2017.Aims and MethodsData came from 2014 to 2017 National Health Interview Survey, an annual, cross-sectional survey of nationally representative samples of US adults (total combined analytic sample n = 125 302). Past-month SPD was assessed using the Kessler Psychological Distress Scale (K6) and cigarette and e-cigarette use were assessed at each wave. Logistic regressions examined product use by SPD status in 2017 and trends in product use by SPD status from 2014 to 2017. Analyses adjusted for demographic covariates.ResultsThe prevalence of cigarette use, e-cigarette use, and dual use was higher among adults with SPD than without SPD in each year including the most recent data year 2017 (cigarette use, 39.50% vs. 13.40%, p &lt; .001; e-cigarette use, 7.41% vs. 2.65%, p &lt; .001; dual use, 5.30% vs. 1.26%, p &lt; .001). Among adults with SPD, the prevalence of cigarette, e-cigarette, and dual product use did not change from 2014 to 2017 in contrast to a decreasing prevalence in cigarette, e-cigarette, and dual product use among individuals without SPD.ConclusionsUS adults with SPD report higher levels of cigarette, e-cigarette, and dual product use than adults without SPD. Use of these products has not declined over the past several years in contrast to decreasing trends among adults without SPD.ImplicationsThese data extend our knowledge of tobacco product use and mental health disparities by showing that in addition to higher levels of cigarette use, US adults with SPD also use e-cigarettes and dual products (cigarette and e-cigarette) more commonly than those without SPD. Furthermore, the use of these products has not declined over the past several years in contrast to continuing declines among adults without SPD. More research is needed to understand the potential positive and negative consequences of e-cigarette use among adults with SPD.
Addressing Diversity in Post-unitary Theories of Order
Authors: Dellavalle Sergio 
Published: April 2020

Abstract
The article analyses the presuppositions that lie behind the transition from the unitary conception of order to the view that a multiplicity of orders should not be denounced as a pathology any longer, but accepted on the one hand as a fact and on the other as a desirable phenomenon. The first step of the analysis consists in introducing the fundamental elements of the unitary conception of order in both its variants: the particularistic and the holistic. Three approaches are then outlined which abandon the unitary notion of order: systems theory, post-modernism and discourse theory. Each of these approaches lays the ground for a specific notion of post-unitary legal order: the idea of the existence of a multiplicity of self-reliant, albeit not mutually indifferent, legal systems in the first case; radical legal pluralism in the second; and cosmopolitan constitutionalism in the third.
The medical evaluation of prepubertal children with suspected sexual abuse
Authors: Smith Tanya , Chauvin-Kimoff Laurel , Baird Burke , Ornstein Amy 
Published: April 2020

AbstractChild sexual abuse is an important and not uncommon problem. Children who have been sexually abused may present to a physician’s office, urgent care centre, or emergency department for medical evaluation. A medical evaluation can provide reassurance to both child and caregiver, identify care needs, and offer an accurate interpretation of findings to the justice and child welfare systems involved. Given the potential medico-legal implications of these assessments, the performance of a comprehensive evaluation requires both current knowledge and clinical proficiency. This position statement presents an evidence-based, trauma-informed approach to the medical evaluation of prepubertal children with suspected or confirmed sexual abuse.
Assessment of the adequacy of counselling regarding reproductive-related issues in women of childbearing age on anti-epileptic drugs
Authors: Murphy O C , Wrigley S , Walsh R A , Freir D B , McCarthy A J , O’Dowd S , McCabe D J H 
Published: April 2020

Abstract

Background
The use of anti-epileptic drugs (AEDs) in women of childbearing age (WCBA) necessitates careful counselling regarding reproductive-related issues.

Aim
(i) To compare documentation of appropriate counselling regarding reproductive-related issues in WCBA prescribed AEDs for non-epilepsy vs. epilepsy indications, and (ii) to examine whether the frequency of counselling improved after introduction of ‘standardized typed advice’.

Design
Retrospective audit and quality assessment and improvement programme.

Methods
We analysed medical records of all WCBA prescribed gabapentin, pregabalin, topiramate, valproate or carbamazepine by a general neurology clinical service before (Study period A) and after (Study period B) introduction of standardized typed passages regarding potential teratogenicity ± interactions with hormonal contraception at a university teaching hospital. The χ2 test or the Fisher’s exact test was employed, as appropriate.

Results
In WCBA prescribed AEDs for non-epilepsy indications, documentation of appropriate counselling regarding potential teratogenicity improved from 49% (17/35 patients) in Period A to 79% (27/34 patients) in Period B (P = 0.008). The frequency of counselling regarding teratogenicity was higher in patients prescribed AEDs for epilepsy compared with non-epilepsy indications in Study period A (100% vs. 49%, P = 0.002), but was no longer significantly different in Study period B (86% vs. 79%, P = 0.64). Documentation of counselling regarding potential interaction of enzyme-inducing AEDs with hormonal contraception did not significantly change between study periods.

Conclusion
Significant improvements in documentation regarding potential teratogenicity of AEDs prescribed for non-epilepsy indications can be achieved by introducing standardized, typed passages copied to patients. Such a practice change is practical and widely applicable to neurological and non-neurological practice worldwide.
Neural mechanisms supporting emotional and self-referential information processing and encoding in older and younger adults
Authors: Daley Ryan T , Bowen Holly J , Fields Eric C , Parisi Katelyn R , Gutchess Angela , Kensinger Elizabeth A 
Published: April 2020

Abstract
Emotion and self-referential information can both enhance memory, but whether they do so via common mechanisms across the adult lifespan remains underexplored. To address this gap, the current study directly compared, within the same fMRI paradigm, the encoding of emotionally salient and self-referential information in older adults and younger adults. Behavioral results replicated the typical patterns of better memory for emotional than neutral information and for self-referential than non-self-referential materials; these memory enhancements were present for younger and older adults. In neural activity, young and older adults showed similar modulation by emotion, but there were substantial age differences in the way self-referential processing affected neural recruitment. Contrary to our hypothesis, we found little evidence for overlap in the neural mechanisms engaged for emotional and self-referential processing. These results reveal that—just as in cognitive domains—older adults can show similar performance to younger adults in socioemotional domains even though the two age groups engage distinct neural mechanisms. These findings demonstrate the need for future research delving into the neural mechanisms supporting older adults’ memory benefits for socioemotional material.