bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Contribution of Frequency Discrimination Ability to Auditory Temporal Patterning Tests in Children
Authors: Flagge Ashley G. , Davis Tara , Henbest Victoria S. 
Published: December 2020

PurposeThe Pitch Patterns Test (PPT) and the Duration Patterns Test (DPT) are clinical auditory processing tests that evaluate temporal patterning skills based on pitch (PPT) or duration (DPT) aspects of sound. Although temporal patterning tests are categorized under the temporal processing domain, successful performance on the PPT also relies on accurate pitch discrimination. However, the relationship between pitch discrimination ability and temporal patterning skills has not been thoroughly evaluated. This study examined the contribution of pitch discrimination ability to performance on temporal patterning in children through the use of a pitch discrimination task and the PPT. The DPT was also given as a control measure to assess temporal patterning with no pitch component.MethodThirty-two typically developing elementary school–age children (6;11–11;3 [years;months]) with normal hearing were given a series of three counterbalanced tasks: an adaptive psychophysical pitch discrimination task (difference limen for frequency [DLF]), the PPT, and the DPT.ResultsCorrelational analysis revealed moderate correlations between DLF and PPT scores. After accounting for age, results of a linear regression analysis suggested that pitch discrimination accounts for a significant amount of variance in performance on the PPT. No significant correlation was found between DLF and DPT scores, supporting the hypothesis that the pitch task had no significant temporal patterning component contributing to the overall score.DiscussionThese findings indicate that pitch discrimination contributes significantly to performance on the PPT, but not the DPT, in a typically developing pediatric population. This is an important clinical consideration in both assessment and utilization of targeted therapy techniques for different clinical populations.
Development of a Hearing Conservation Program for Elementary Schools
Authors: Daney Samantha , Pakulski Lori A. , Diehm Emily A. , Glassman Jennifer 
Published: December 2020

Purpose
Despite evidence supporting the positive implications of hearing conservation programs (HCPs) on hearing loss prevention among children, healthy hearing habits are often not taught in schools. To address the need for more hearing health education in schools, we investigated the feasibility of a teacher-implemented HCP and its impact on fourth-grade students.

Method

A speech-language pathology graduate student trained a science teacher from a local elementary school to implement a modified version of the American Speech-Language-Hearing Association's HCP,
Listen to Your Buds
, to 56 fourth-grade students. After completing a pre-intervention questionnaire, students received a 45-min interactive HCP, with posttesting occurring immediately afterward and 4 weeks later. Students answered questions to measure their hearing-related knowledge, attitudes, and behaviors as a result of participation in the HCP.

Results
Immediately following the program, students' knowledge of potentially damaging noises increased, as well as did their attitudes toward noise exposure. Students' responses remained similar one month after the HCP as well. However, few students reported behavioral changes related to potentially damaging noise exposure.

Conclusions

A single 45-min intervention did not appear to change students' intentions for future behaviors regarding healthy hearing habits; however, results indicate that students increased their knowledge and improved their attitudes, which may indeed impact future behavior when confronted with potentially damaging noise exposure. Although
Listen to Your Buds
materials are no longer accessible online, we provide recommendations for school-based speech-language pathologists and educational audiologists to develop and implement an HCP in their school.
Treatment Considerations for Adolescents Who Exhibit Cognitive/Communication Problems: A Neuroscience Perspective
Authors: Burns Martha S. 
Published: December 2020

Purpose
Adolescence is a period of substantial neurophysiological and behavioral growth, representing a second sensitive period of brain development. It is a psychological and social transition period between childhood and adulthood with many beneficial changes occurring, especially with respect to potential responsiveness to clinical intervention. However, adolescent behavioral complexities introduce clinical challenges as well. The purpose of this review article is to review the current neuroimaging research on neurophysiological changes observed during adolescence and the cognitive and social behavioral counterparts, with specific attention to the clinical implications. The review article will then summarize currently available intervention tools that can be utilized by speech-language pathologists working with this population. It will conclude with available evidence-based social-communication approaches that may be applicable as well as available evidence-based supplemental technological cognitive interventions that may be useful in working with adolescents who exhibit language and communication issues.

Conclusion
As a transition period between childhood and adulthood, adolescence represents a second sensitive period during which there is opportunity for clinically derived beneficial cognitive and communication growth.
Computer-Assisted Challenge Point Intervention for Residual Speech Errors
Authors: McAllister Tara , Hitchcock Elaine R. , Ortiz José A. 
Published: December 2020

Purpose
This preliminary case series investigated the effects of biofeedback intervention for residual rhotic errors delivered within a modified challenge point framework. In the challenge point framework, practice difficulty is adaptively adjusted with the goal of enhancing generalization learning. This study more specifically evaluated the feasibility of a computer-mediated implementation of challenge point treatment for rhotic errors using a custom open-source software, the Challenge Point Program.

Method
Participants were five native English speakers, ages 7;3–15;5 (years;months), who had established but not generalized correct rhotic production in previous treatment; overall treatment duration was flexible. Treatment incorporated either electropalatographic or visual-acoustic biofeedback and was structured by challenge point principles implemented using the Challenge Point Program software.

Results
Participants were highly variable in the magnitude of generalization gains attained. However, the median overall effect size was 4.24, suggesting that participants' response in treatment tended to exceed the minimum value considered clinically significant.

Conclusion
These findings provide preliminary evidence that computer-mediated implementation of the challenge point framework can be effective in producing generalization in some participants.

Supplemental Material

https://doi.org/10.23641/asha.13244501
Treatment of Recurrent Epithelial Ovarian Cancer
Authors: Claussen Carlota , Rody Achim , Hanker Lars 
Published: December 2020

AbstractEpithelial ovarian cancer is the most common cause of death from gynecological tumors. Most patients with advanced ovarian cancer develop recurrence after concluding first-line therapy, making further lines of therapy necessary. The choice of therapy depends on various criteria such as tumor biology, the patientʼs general condition (ECOG), toxicity, previous chemotherapy, and response to chemotherapy. The platinum-free or treatment-free interval determines the potential response to repeat platinum-based therapy. If patients have late recurrence, i.e. > 6 months after the end of the last platinum-based therapy (i.e., they were previously platinum-sensitive), then they are usually considered suitable for another round of a platinum-based combination therapy. Patients who are not considered suitable for platinum-based chemotherapy are treated with a platinum-free regimen such as weekly paclitaxel, pegylated liposomal doxorubicin (PLD), gemcitabine, or topotecan.
Treatment for the patient subgroup which is considered suitable for platinum-based therapy but cannot receive carboplatin due to uncontrollable hypersensitivity reactions may consist of trabectedin and PLD. While the use of surgery to treat recurrence has long been a controversial issue, new findings from the DESKTOP III study of the AGO working group have drawn attention to this issue again, particularly for patients with a platinum-free interval of > 6 months and a positive AGO score. Clinical studies have also shown the efficacy of angiogenesis inhibitors such as bevacizumab and the PARP inhibitors olaparib, niraparib and rucaparib. These drugs have substantially changed current treatment practice and expanded the range of available therapies. It is important to differentiate between purely maintenance therapy after completing CTX, continuous maintenance therapy during CTX, and the therapeutic use of these substances. The PARP inhibitors niraparib, olaparib and
rucaparib have already been approved for use by the FDA and the EMA. The presence of a BRCA mutation is a predictive factor for a better response to PARP inhibitors.
Aloe vera in der Onkologie
Authors: Rist Maike , Langhorst Jost 
Published: December 2020

ZusammenfassungAloe vera ist durch die antioxidativen und entzündungshemmenden Eigenschaften ein vielseitig einsetzbares Heilmittel der Naturheilkunde, das sowohl in der traditionellen Medizin weltweit als auch in der westlichen Medizin vielfach Anwendung findet. Zu den Hauptindikationen zählt die Behandlung von Wunden, Erfrierungen und Verbrennungen, Psoriasis, Colitis ulcerosa, Diabetes und Obstipation (Verstopfung) sowie Linderung chemo- und strahlentherapeutischer Nebenwirkungen. Von großer Bedeutung für die Medizin ist die Unterscheidung zwischen Aloe-vera-Gel, das sich als Wasserspeichergewebe im Inneren der Blätter befindet, und dem Blattsaft (auch Latex genannt), der sich direkt unter der Haut der Blätter befindet, da sich die Inhaltsstoffe dieser Pflanzenbestandteile grundlegend unterscheiden: Den im Blattsaft enthaltenen Anthrachinonen (wie Aloin, Aloe-Emodin u. a. ) werden eine abführende Wirkung, aber auch toxische und kanzerogene Eigenschaften zugeschrieben, wohingegen das Gel vor allem in topischer Anwendung als unbedenklich und sicher gilt. Die orale Einnahme von Aloe vera, insbesondere in Latexform, kann zu Magen-Darm-Störungen und Elektrolytanomalien führen und gilt während der Schwangerschaft und Stillzeit als kontraindiziert. In Bezug auf die Toxizität ist die Studienlage widersprüchlich und neben Daten, die für eine schädigende Wirkung der Anthrachinone sprechen, gibt es Ergebnisse, die sowohl in Tierstudien als auch in vitro eine antikanzerogene Wirkung nachweisen. Eine entscheidende Rolle könnte sowohl die verwendete Aloe-Art als auch der Anthrachinongehalt der verwendeten Produkte spielen. Qualitativ hochwertige Studien und neue Forschungsergebnisse sowie eine klare Differenzierung zwischen Aloe-vera-Gel und anthrachinonhaltigen Bestandteilen der Pflanze sind notwendig, um weitere Ergebnisse und mehr Sicherheit in Bezug auf die Toxizität wie auch auf das gesundheitsfördernde Potenzial dieser Pflanze liefern zu können.Die Fortschritte in der Analyse der Tumor-Immunbiologie lassen hoffen, dass die antineoplastische Eigenschaft, die auf einer antiproliferativen, immunstimulierenden und antioxidativen Wirkung beruht, in naher Zukunft weiter erforscht wird.
Abdominal Applications of 4D Flow MRI
Authors: Riedel Christoph , Lenz Alexander , Fischer Lutz , Li Jun , Piecha Feilix , Kluwe Johannes , Adam Gerhard , Bannas Peter 
Published: December 2020

Background Four-dimensional flow magnetic resonance imaging (4D flow MRI) provides volumetric and time-resolved visualization and quantification of blood flow. This review presents an overview of possible applications of 4D flow MRI for non-invasive assessment of abdominal hemodynamics.
Method This review is based on the authors’ experience and the current literature. A PubMed database literature research was performed in December 2019 focusing on abdominal applications of 4D flow MRI. We illustrated the review with exemplary figures and movies of clinical cases from our institution.
Results and Conclusion 4D flow MRI offers the possibility of comprehensive assessment of abdominal blood flows in different vascular territories and organ systems. Results of recent studies indicate that 4D flow MRI improves understanding of altered hemodynamics in patients with abdominal disease and may be useful for monitoring therapeutic response. Future studies with larger cohorts aiming to integrate 4D flow MRI in the clinical routine setting are needed.
Key Points:
Citation Format
Die Schilddrüse – Versuch einer ganzheitlichen Einordnung als somato-emotionale Schnittstelle
Authors: Sperlich Franz 
Published: December 2020

ZusammenfassungDie Schilddrüse spielt sowohl in unserer individuellen Entwicklung als auch für unsere körperliche und geistige Gesundheit als Erwachsener eine zentrale Rolle. In diesem Beitrag erfolgt eine Einordnung der Schilddrüse als somato-emotionale Schnittstelle auf Basis phylo- und ontogenetischer, anatomischer und physiologischer Fakten. Anhand des Modells Globe of Emotions® und „Bodily Maps of Emotion“ wird Ekel unter Einbeziehung erfahrungsheilkundlicher Aspekte als immunwirksame Emotion mit topografischem Bezug zur Schilddrüse sowie ein möglicher Kausalzusammenhang mit Autoimmunerkrankungen dieses Organs diskutiert.
Residual Axillary Burden After Neoadjuvant Chemotherapy (NACT) in Early Breast Cancer in Patients with a priori Clinically Occult Nodal Metastases – a transSENTINA Analysis
Authors: Kolberg Hans-Christian , Kühn Thorsten , Krajewska Maja , Bauerfeind Ingo , Fehm Tanja N. , Fleige Barbara , Helms Gisela , Lebeau Annette , Stäbler Annette , Schmatloch Sabine , Hauschild Maik , Schwentner Lukas , Schrenk Peter , Loibl Sibylle , Untch Michael , Kolberg-Liedtke Cornelia 
Published: December 2020

Abstract
Background Among patients with breast cancer undergoing neoadjuvant chemotherapy (NACT), the association between pathological complete remission (pCR) in the breast and clinical/pathological parameters is well established, whereas the association between these parameters and residual axillary involvement after NACT remains unclear.
Methods Patients with clinically occult nodal metastases (i.e. negative by clinical assessment but positive by SLNB prior to NACT, i.e. Arm B of the SENTINA trial) were included in the presented analysis. All patients received a second sentinel lymph node biopsy (SLNB) and axillary dissection after NACT. Univariate and multivariate analyses were carried out to evaluate the association between clinical/pathological parameters and axillary involvement after NACT.
Results Arm B of the SENTINA study contained 360 patients, 318 of which were evaluable for this analysis. After NACT, 71/318 (22.3%) patients had involved SLNs or non-SLNs after NACT. Overall, 71/318 (22.3%) patients achieved a pCR in the breast. Associations of extranodal spread, lack of multifocality and pCR in the breast with residual axillary burden were statistically significant. In a descriptive analysis including all patients with clinically negative axilla before NACT in the SENTINA trial 1.2% of triple negative (TN) patients and 0.5% of HER/2 positive patients had residual axillary disease in case of a breast pCR.
Conclusions Patients in the SENTINA trial with clinically negative axilla and involved SLNs still carried a significant risk of nodal metastases after NACT. However, the risk of residual axillary burden was particularly low in TN and HER/2 positive tumors in case of a breast pCR.
ω-3-Fettsäuren in der Schwangerschaft – kein Frühchen und glückliche Mutter
Authors: Schmiedel Volker 
Published: December 2020

ZusammenfassungDie ausreichende Versorgung mit ω-3-Fettsäuren kann neben anderen Nährstoffen zu einer komplikationslosen Schwangerschaft und zur Geburt eines gesunden Kindes beitragen: Das Risiko für Frühgeburten, perinatalen Tod, Gestationsdiabetes sowie Depression während der Gravidität und postpartal sinkt. Besonders wichtig sind die maritimen Fettsäuren Docosahexaensäure (DHA) für die Entwicklung des Nervensystems und Eicosapentaensäure (EPA) für die Prävention atopischer Erkrankungen. Empfehlenswert ist die Fettsäurenanalyse in der Erythrozytenmembran vor bzw. zu Beginn der Schwangerschaft und in deren Verlauf. Für die Substitution eignen sich hochwertiges Fisch- oder Algenöl.
Gegenseitige Unterstützung Psychiatrieerfahrener in Krisenunterkünften – ein Scoping Review
Authors: von Peter Sebastian , Schwarz Julian 
Published: December 2020

ZusammenfassungZiel Als Alternative zur psychiatrischen Versorgung gibt es v. a. im angloamerikanischen Raum sogenannte Crisis Respites (CR), in denen sich krisen- und genesungserfahrene Menschen (Peers) gegenseitig unterstützen. In dieser Arbeit wird untersucht, wie CR aufgebaut sind und mit welchen Ansätzen und Ergebnissen sie evaluiert werden.Methodik Systematische Literaturrecherche. Studien wurden eingeschlossen, auch der „grauen“ Literatur, sofern sie empirisches Material enthielten.Ergebnisse Auswahl von 12 Publikationen mit Bezug zu insgesamt 10 CR. Die Arbeits- und Organisationsformen von CR sind sehr heterogen. Es wurden unterschiedliche Evaluationsansätze (RCT, qualitativ, Mixed-Methods) genutzt.Schlussfolgerung CR sind kein Ersatz für die psychiatrische Versorgung, sondern eine eigene, wirksame Unterstützungsform. Der Einfluss von Peers bei der Umsetzung und Evaluation ist von zentraler Bedeutung, damit ihre Eigenheiten erhalten bleiben.
Perspektiven von Medizinischen Fachangestellten zu teambasierter Behandlung von Patienten mit Panikstörung in der Hausarztpraxis – Eine qualitative Studie
Authors: Blank Wolfgang A. , Lukaschek Karoline , Breitbart Jörg , Hiller Thomas S. , Brettschneider Christian , Margraf Jürgen , Gensichen Jochen ,   für die PARADIES-Studiengruppe
Published: December 2020

Zusammenfassung
Ziel der Studie Untersuchung der Perspektive von Medizinischen Fachangestellten (MFA) bezüglich der Mitwirkung in verhaltenstherapeutisch orientierten Interventionen in der Hausarztpraxis.
Methode 15 MFA (w, 39,5 Jahre), Case-Manager in einem hausarztpraxis-unterstützten Übungsprogramm für Patienten mit Panik- und Angststörung (ICD-10: F41.0), wurden mittels semistrukturiertem Interviewleitfaden zur Rekrutierung von und Interaktion mit Patienten, Vermittlung der Übungen und der Implementierung in den Praxisalltag befragt. Die Interviews (n = 14) wurden dokumentiert, transkribiert und inhaltsanalytisch nach Mayring qualitativ analysiert.
Ergebnisse MFA empfanden ihren Anteil an der Intervention im Rahmen der Rekrutierung und Bindung von Patienten ans Projekt durch Telefonkontakte als positiv.
Schlussfolgerung Das Einbinden der MFA kann dazu beitragen, im Rahmen einer niedrigschwelligen Intervention Patienten mit psychischen Beschwerden in der hausärztlichen Versorgung gezielt zu unterstützen und den Hausarzt zu entlasten.
Contributing to the Study of Enzymatic and Chemical Glycosyl Transfer Through the Observation and Mimicry of Glycosyl Cations
Authors: Blériot Yves 
Published: December 2020

AbstractThis account describes our efforts dedicated to: 1) the design of glycomimetics aimed at targeting therapeutically relevant carbohydrate processing enzymes, and 2) the observation, characterization, and exploitation of glycosyl cations as a tool for studying the glycosylation reaction. These findings have brought important data regarding this key ionic species as well as innovative strategies to access iminosugars of interest.1	Introduction2	The Glycosyl Cation, A Central Species in Glycosciences2.1	A Selection of the Strategies Developed so far to Gain Insights into Glycosyl Cations Structure2.2	When Superacids Meet Carbohydrates3	Chemical Probes to Gain Insights into the Pseudorotational Itinerary of Glycosides During Glycosidic Bond Hydrolysis3.1	Conformationally Locked Glycosides3.1.1	The Xylopyranose Case3.1.2	The Mannopyranose Case3.2	Conformationally Flexible Iminosugars3.2.1	Nojirimycin Ring Homologues3.2.2	Noeuromycin Ring Homologues3.2.3	Seven-Membered Iminosugar C-Glycosides4	N-Acetyl-d-glucosamine Mimics5	Ring Contraction: A Useful Tool to Increase Iminosugar’s Structural Diversity6	Regioselective Deprotection of Iminosugar C-Glycosides to Introduce Diversity at C2 Position7	Conclusion
Antimicrobial Dressing versus Standard Dressing in Obese Women Undergoing Cesarean Delivery: A Randomized Controlled Trial
Authors: Saad Antonio F. , Salazar Ashley E. , Allen Lindsey , Saade George R. 
Published: December 2020

Objective This study aimed to evaluate the effect of a novel antimicrobial dressing on patient satisfaction and health-related quality of life (HRQoL) following a cesarean delivery.
Study Design  This was an open-label, single-center, two-arm randomized controlled trial. This study was done at the tertiary center, maternal unit, Galveston, TX. Pregnant women with body mass indices ≥35 kg/m2 were screened for eligibility. Women were randomized to ReliaTect Post-Op Dressing (RELIATECT) or standard wound dressing (STANDARD). Primary outcome was patient satisfaction and HRQoL using validated questionnaires. Secondary outcomes were provider satisfaction, surgical site infection (SSI) rates, and wound complications.
Results In total, 160 women were randomized. Population characteristics were not significant among groups. RELIATECT dressing group had an overall higher score of satisfaction and HRQoL compared with STANDARD group. Women in the RELIATECT group reported less incision odor and incisional pain. Compared with the STANDARD group, most women in RELIATECT dressing group reported better daily activities, self-esteem, personal hygiene, body image, and sleep. Providers reported that the RELIATECT dressing allowed better assessment of the surgical incision site, allowed patients to shower early, and did observe less wound dressing leakage. No differences were found in other secondary end points.
Conclusion Postcesarean RELIATECT dressing for wound care in pregnant women with obesity had better patient and provider satisfaction as well as better HRQoL scores. Further, level 1 evidence is needed to assess its impact on SSI rates and wound complication, as this trial was not powered to accomplish this goal.
Key Points
Do You Know What Your Scribe Did Last Spring? The Impact of COVID-19 on Medical Scribe Workflow
Authors: Gold Jeffrey A. , Becton James , Ash Joan S. , Corby Sky , Mohan Vishnu 
Published: December 2020

Abstract
Objective To understand the impact of the shift to virtual medicine induced by coronavirus disease 2019 (COVID-19) has had on the workflow of medical scribes.
Design This is a prospective observational survey-based study.
Setting This study was conducted at academic medical center in the United States.
Participants Seventy-four scribes working in ambulatory practices within an academic medical center.
Interventions All medical scribes received a survey assessing their workflow since beginning of COVID-19 restrictions.
Primary and Secondary Outcomes To assess the current workflow of medical scribes since transition to virtual care. Secondary outcomes are to assess the equipment used and location of their new workflow.
Results Fifty-seven scribes completed the survey. Overall 42% of scribes have transitioned to remote scribing with 97% serving as remote scribes for remote visits. This workflow is conducted at home and with personal equipment. Of those not working as scribes, 46% serve in preclinic support, with a wide range of EHR-related activities being reported. The remaining scribes have been either redeployed or furloughed.
Conclusion The rapid transition to virtual care brought about by COVID-19 has resulted in a dramatic shift in scribe workflow with the adoption of a previously unreported workflow of remote scribing for virtual care. Additional work is now needed to ensure these new workflows are safe and effective and that scribes are trained to work in this new paradigm.