bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of overweight and obesity on women with urinary incontinence: pilot study
Authors: Brilhante Magdalena Muryelle Silva , Micussi Maria Thereza Albuquerque Barbosa Cabral , Dantas Diego de Sousa , Neves Ana Isabele Andrade , Oliveira Camila Vasconcelos de Arruda , Oliveira Jaine Maria De Pontes , Magalhães Adriana Gomes , Correia Grasiéla Nascimento 
Published: August 2020

Abstract
IntroductionTo assess whether obesity has a greater impact than overweight on urinary incontinence severity, pelvic floor muscle function, and quality of life in women with urinary incontinence. MethodsA pilot cross-sectional study using a convenience sample. Twenty-six volunteers were evaluated and divided into: Overweight Group (n=11) with BMI (body mass index) between 25.0-29.9kg/m²; Obesity Group (n=15) BMI≥30.0kg/m². The volunteers performed the urogynecological evaluation, Incontinence Severity Index (ISI), the King’s Health Questionnaire (KHQ), 1-hour pad test and evaluation of pelvic floor muscle function. Statistical analysis: Shapiro–Wilk test and the Mann-Whitney test for intergroup analysis. The significance level: p≤0.05. ResultsThe average age was 61.09(12.51) in the Overweight Group and 55.93(9.03) years in the Obesity Group. The Overweight Group presented better fast fiber contraction (p=0.03) of the pelvic floor muscle. There were no differences in the ISI and quality of life between the groups. ConclusionsThere was no difference in the impact caused by being overweight or obese in relation to urinary incontinence severity, pelvic floor muscle function and quality of life, except for fast fiber contraction in which Overweight Group showed better results.
Non-invasive monitoring of fiber fermentation in healthy volunteers by analyzing breath volatile metabolites: lessons from the FiberTAG intervention study
Authors: Neyrinck Audrey , Rodriguez Julie , Zhang Zhengxiao , Seethaler Benjamin , Mailleux Florence , Vercammen Joeri , Bindels Laure B. , Cani Patrice D. , Nazare Julie-Anne , Maquet Véronique , Laville Martine , Bischoff Stephan C. , Walter Jens , Delzenne Nathalie 
Published: August 2020

Abstract
Background: The fermentation of dietary fibers (DF) leads to the production of bioactive metabolites, the most volatile ones being excreted in the breath. The aim of this study was to analyze the profile of exhaled breath volatile metabolites (BVM) and gastro-intestinal symptoms in healthy volunteers after a single ingestion of maltodextrin (placebo) versus chitin-glucan (CG), an insoluble DF previously shown to be fermented into short-chain fatty acids (SCFA) by the human microbiota in vitro.Methods: 4.5 g maltodextrin (day 0) or 4.5 g CG (day 2) were added to a standardized breakfast in fasting healthy volunteers (n=15). BVM were measured using selected ion flow tube mass spectrometry (SIFT-MS) throughout the day, as well as gastrointestinal tolerance by using validated visual analogue scale. Faecal gut microbiota (Illumina 16S rRNA sequencing) and SCFA (gas chromatography with flame-ionization detection) were analyzed prior to intervention. Results: A single ingestion of 4.5 g CG did not induce significant gastrointestinal discomfort. Untargeted metabolomics analysis of breath highlighted that 13 MS-fragments (among 408 obtained from ionizations of breath) discriminate CG versus maltodextrin acute intake in the postprandial state. Targeted analysis revealed that CG increased exhaled butyrate, but also 5 other BVM – including the microbial metabolites 2,3-butanedione and 3-hydroxybutanone – with a peak observed 6h after CG intake. Correlation analyses spotlighted Mitsuokella as a potential genus responsible for the presence of butyric acid, triethylamine and 3-hydroxybutanone in the breath.Conclusion: Measuring BMV in the breath reveals the microbial signature of the fermentation of DF after a single ingestion. This standardized protocol allows to analyze the time-course of released bioactive metabolites that could be proposed as new biomarkers of DF fermentation, potentially linked to their biological properties.
Performance of Bidimensional Location Quotients for Constructing Input-Output Tables
Authors: Pereira-López Xesús , Sánchez-Chóez Napoleón Guillermo , Fernández-Fernández Melchor 
Published: August 2020

Abstract
This article seeks to verify the extent at which the formulation of two-dimensional location quotients (2D-LQ) entails a methodological advance in building or generating economic accounts related to sub-territories drawing from basic information. The input-output tables of the Euro Area 19 for 2010 and 2015 are taken as a reference for analysis, and five statistics are used to measure the degree of similarity between the true domestic coefficient matrices for ten countries (namely Austria, Belgium, Estonia, France, Germany, Italy, Latvia, Slovakia, Slovenia and Spain) and the matrices generated from them using non-survey techniques CILQ, FLQ, AFLQ and 2D-LQ. Focus is substantially centred on comparing the results from the four aforementioned techniques to rank methodological efficiency. Standard parameters (associated with 2D-LQ) are also provided as a guide in this scope of work with a view to ascertaining optimal parameters.
External Stenting of Vein Grafts in Coronary Artery Bypass Grating: Interim Results from a Two Centers Prospective Study
Authors: Weltert Luca , Audisio Katia , Bellisaro Alessandro , Bardi Gianluca , Flocco Roberto , De Paulis Ruggero , Centofanti Paolo 
Published: August 2020

Abstract
Background – Previous studies evaluating external stents for saphenous vein grafts (SVG) in CABG were limited to on-pump isolated CABG and single grafting technique with one external stent per patient. The objective of this prospective study was to evaluate the safety and the short-term performance of external stents in heterogeneous group of patients which underwent on and off-pump CABG, single and sequential grafting.Methods - 102 patients undergoing CABG were enrolled in two centers. All patients received internal mammary artery to the left anterior descending artery and additional arterial and/or venous grafts. In each patient, at least one SVG was supported with an external stent. Grafts’ patency and SVG lumen uniformity were assessed using CT angiography at a pre-defined time window of 6-12 months post procedure. All patients were prospectively followed-up via phone call and/or visit every 6 months for Major Adverse Cardiac and Cerebrovascular Events.Results - 51 patients (50%) underwent off-pump CABG and 23 patients (23%) were grafted with bilateral internal mammary arteries. Each patient received one or more SVG grafted in a sequential technique (44%) or as single graft (56%). All SVG were externally stented in 84% of patients and in 16% (n=16) one SVG was stented and one remained unsupported. At 6-12 months, patency rates of LIMA, RIMA, externally stented SVG and none-stented SVG were 100%, 100%, 98% and 87.5% respectively. 90% of the externally stented SVG had uniform lumen compared to 37% of the non-stented SVG. Clinical follow-up was completed for all patients with a mean duration of 20 months (range 6-54 months). During follow up period, one patient experienced myocardial infarction due to occlusion of the LIMA-LAD graft and one patient experienced transient ischemic attack.Conclusions - External stenting of SVG is feasible and safe in CABG setting which includes off pump CABG and sequential SVG grafting and associated with acceptable early patency rates.Study registration- Study was registered at ClinicalTrials.gov. NCT01860274 (initial release 20.05.2013)
Findings and Feasibility of Major Salivary Gland Ultrasound in Childhood-Onset Systemic Lupus Erythematosus: A Pilot Study
Authors: McDonald Joseph , Vega-Fernandez Patricia , Ting Tracy 
Published: August 2020

Abstract
Background: Childhood-onset systemic lupus erythematosus (cSLE) is a complex autoimmune disorder with multi-organ manifestations and can be associated with other rheumatic diseases including Sjögren’s syndrome (SS). Salivary gland ultrasound (SGUS) represents a noninvasive tool to screen for salivary gland disease in rheumatic disease patients. The aims of this cross-sectional study were to determine feasibility of major SGUS in a clinic setting and to identify characteristics in a cohort of cSLE patients (without confirmed SS) that may be associated with salivary gland abnormalities consistent with secondary SS.Methods: Patients with SLE onset prior to age 18 were recruited. Patients completed questionnaires rating symptoms and underwent major SGUS examination. Disease and demographic differences were compared between cSLE patients with abnormal SGUS vs. cSLE patients with normal SGUS using t-tests and Fisher’s exact tests.Results: 31 cSLE patients were recruited, 84% were female, 55% were Caucasian. The average disease duration among all patients was 5 years. Average time to complete the SGUS examination and scoring protocol was 7 minutes. 35% of SGUS scores were abnormal and significantly associated with IgG level at diagnosis, and anti-Ro and anti-La antibodies.Conclusions: This is the first study to assess major SGUS in a cohort of patients with cSLE without prior diagnoses of SS. The SGUS protocol was feasible to perform by rheumatologists in a clinic setting. Although the sample size was small, SGUS abnormalities were identified in one-third of patients. IgG level at diagnosis and anti-Ro and anti-La antibodies may be associated with SGUS abnormalities.
Investigating the Effects of COVID-19 Quarantine in Migraine: An Observational&nbsp;Cross-Sectional Study from the Italian National Headache Registry&nbsp;(RICe)
Authors: Delussi Marianna , Gentile Eleonora , Coppola Gianluca , Prudenzano Addolorata Maria Pia , Rainero Innocenzo , Sances Grazia , Abagnale Chiara , Caponnetto Valeria , De Cesaris Francesco , Frattale Ilaria , Guaschino Elena , Marcinno' Andrea , Ornello Raffaele , Pistoia Francesca , Putorti' Alessia , Roca Maria Elena , Roveta Fausto , Trojano Maria , Pierelli Francesco , Geppetti Pierangelo , Sacco Simona , De Tommaso Marina 
Published: August 2020

Abstract
BACKGROUND: Previous studies during SARS and Ebola pandemics have shown that quarantine is associated with several negative psychological effects, such as post-traumatic stress symptoms, confusion and anger. These conditions may affect the course of many diseases, including migraine. Although it is possible that the quarantine measures for the current COVID-19 pandemic affect migraine burden, no information is currently available on this issue. AIM: In this study, we aimed to: 1) explore the possible changes in migraine frequency, severity, and days with acute medication intake during quarantine period; 2) evaluate possible differences in migraine outcomes in consideration of lifestyle changes, emotions, pandemic diffusion, and COVID-19 infection. METHODS : We interviewed patients who were included in the observational Italian Headache Registry (Registro Italiano Cefalee, RICE), retrospectively collecting information on main headache features, lifestyles factors, emotions, individual infection status, and perception of COVID-19 for two months before (pre-quarantine) and after the beginning of the quarantine (quarantine). Inclusion criteria were: age > 18, diagnosis of migraine without aura, migraine with aura and chronic migraine, last in-person visit more than 3 months preceding the beginning of quarantine. RESULTS: A total of 433 migraine subjects agreed to be interviewed. We found an overall reduction in headache frequency and intensity during the quarantine, compared to pre-quarantine. There was a correlation between improvement and number of days of stay-at-home. When results were stratified for geographic area, we found a tendency towards worsening of headache frequency in northern Italy. Disgust regarding viral infection corresponded to a minor improvement in migraine.CONCLUSIONSMigraine patients showed resilient behavior toward pandemic distress. Disgust regarding the contagion whereas potentially favoring defensive behavior, could potentially worsen migraine.
Level of Stress in Ganale Dawa Hydropower Dam construction workers: A Cross Sectional Study
Authors: Yenealem Dawit Getachew , Dagne Henok , Hussen Jemal 
Published: August 2020

Abstract
Background:Stress is the harmful physical and emotional response caused by an imbalance between the perceived demands and the perceived resources and abilities of individuals to cope with those demands. In the developing world, work-related stress is an issue of growing concern. Work-related stress can severely impact workers' general achievement levels in a negative way concerning both efficiency and accuracy. Thus striving to determine the level of stress at a job and its contributory factors will be insatiable input for intervention.Method: An institutional-based cross-sectional study was conducted to assess the prevalence and associated factors of job stress among Ganale Dawa 3D Hydropower Dam construction workers from April1-22, 2018. Data were collected using a structured questionnaire on 405 workers. Multivariable logistic regression analysis with a 95% confidence interval (CI) was used to identify the factors significantly associated with a good level of food hygiene knowledge. P-value less than 0.05 was used to declare statistical significant association.Result: A quarter of construction workers,24.7% [95% CI: (20.5%, 28.0%)]suffered from stress in their workplace. Being at young (AOR: 3.07, 95% CI: 1.45, 6.47) and middle (AOR: 3.94 95% CI: 1.27, 12.24)ages; sustain injury in 12 months (AOR: 2.6095% CI: 1.40, 4.80), shiftwork (AOR: 2.22 95% CI: 1.03, 4.79) and working over 48 hours per week (AOR: 4.5495% CI: 2.40, 8.56)were significantly associated with stress. Conclusion: This study showed that construction work is one of the most stressfuloccupations. It also suggeststhat age of workers, history of injury within 12 months of the study, shift work, and working over 48 hours per week were significantly associated with stress. Therefore, much has to be done by introducing flexible working hours that do not exceed 48 hours per week, avoiding long hours of shift work longer than 8hours and protecting the workers from work-related injury.
Yield and survival rate of ‘Gigante’ cactus pear under regulated deficit irrigation using wastewater
Authors: Souza José Alberto Alves de , Santos Delfran Batista dos , Donato Sérgio Luíz Rodrigues 
Published: August 2020

Abstract
This study aimed to evaluate the yield and survival rate of 'Gigante' cactus pear (Opuntia fícus indica) cultivated with regulated deficit irrigation (RDI) using wastewater under semiarid soil and climatic conditions. The experiment was carried out between October 2015 and August 2017 at Instituto Federal Baiano, campus Guanambi, Brazil. The treatments were as follows: no fertilization and no irrigation (T1); no fertilization and RDI with wastewater (0.6 L plant-1 week-1) (T2); no fertilization and RDI with wastewater (1.2 L plant-1 week-1, applied once a week) (T3); no fertilization and RDI with wastewater (1.2 L plant-1 week-1, divided into two applications per week) (T4) with organic fertilization (60 Mg ha-1 of bovine manure) and RDI with common water (1.2 L plant-1 week-1) (T5) and with organic fertilization (60 Mg ha-1 of bovine manure) and no irrigation (T6). The treatments were arranged in a randomized complete block design with five replicates. Based on the results, we concluded that (i) regulated deficit irrigation using wastewater increased the productivity of 'Gigante' cactus pear when compared to the rainfed crop and (ii) the application of 0.6 L plant-1 week-1 was sufficient to increase the survival rate of 'Gigante' cactus pear under prolonged drought conditions.
HIV-1 versus SARS-CoV-2 infection: understanding the population genetic aspects of drug inefficacy (especially ivermectin) in the integrase-importin complex
Authors: Felix Pierre Teodosio 
Published: August 2020

Abstract
Therapies with new drugs have been appearing in tests worldwide as potential inhibitors of sars-cov-2 virus replication. Recently, one of these drugs, Ivermectin, was reported as an inhibitor of the nuclear import of HIV-1 proteins in vitro, soon becoming the target of an international prospecting work (not yet published), with patients tested for COVID-19. However, understanding the evolutionary aspects of the biological components involved in the complex drug-nuclear import helps in understanding how these relationships exist in the deactivation of viral infections. Thus, 153 sequences of the HIV-1 integrase gene were analyzed for their genetic structure and molecular diversity and the presence of two distinct groups for the Gene and not only one, was detected; As well as different degrees of structuring for each of these groups. These results support the interpretation of the lack of conservation of the HIV-1 gene and that the number of existing polymorphisms, only for this structure of the complex, implies the non-efficiency of a drug at population levels. Thus, the molecular diversity found in HIV-1 can be extrapolated to other viruses, such as Including, SARS-CoV-2 and the functionality of the drug, interacting with the integrase-importin complex, can be further decreased.
Association of the Non-HDL-cholesterol to HDL-cholesterol Rate and the Risk of Non-alcoholic Fatty Liver Disease Among Children and Adolescence: A Retrospective Cohort Study
Authors: Yang Shouxing , Zhong Jinwei , Ye Mengsi , Miao Le , Lu Guangrong , Xu Changlong , Xue Zhanxiong , Zhou Xinhe 
Published: August 2020

Abstract
Background: The non-HDL-cholesterol to HDL-cholesterol (non-HDL-c/HDL-c) rate shows a close relationship to multiple dyslipidemia related disease. This paper aims at investigating the association of the non-HDL-c/HDL-c rate and the risk of NAFLD among children and adolescence in China.Methods: In this retrospective cohort study, a total of 7759 eligible children and adolescence (5692 boys, 2067 girls) having received regular medical examination were recruited. We collected anthropometric measurements and laboratory tests data of subjects. The binary logistics regression was employed for the assessment of the associations of the non-HDL-c/HDL-c rate with NAFLD. Sex-specific ROC curve analysis was conducted for comparing the predictive value of non-HDL-c/HDL-c rate, non-HDL-c and HDL-c for NAFLD.Results: The total NAFLD prevalence was 4.36%, higher in boys than that in girls (5.61% vs. 1.9%, P<0.001). It is noteworthy that NAFLD prevalence displayed positive correlation with the non-HDL-c/HDL-c rate（Chi-square test, P<0.001). The binary logistics regression analysis shows that the OR were 8.61 (95% CI = 5.90-12.57, P< 0.001) in the maximum tertiles (maximum non-HDLc/HDLc ratio) compared with the minimum tertiles. When potential confounders were regulated, compared with the minimum tertiles, the OR for the maximum tertiles (OR=3.94, 95%CI=2.33-6.66, P< 0.001) was still significantly higher. AUC values of the non-HDL-c/HDL-c rate ( 0.787 in boys and 0.763in girls) noticeably reached over non-HDL-c (0.719 in boys and 0.661 in girls) and HDL-c (0.726 in boys and 0.732 in girls). Furthermore, the optimal cutoff value of the non-HDL-c/HDL-c rate for NAFLD was 2.475 in boys and 2.695 in girls.Conclusions: The present study indicate that a higher non-HDL-c/ HDL-c rate caused a higher risk of NAFLD among children and adolescence. Moreover, the non-HDL-c/HDL-c rate showed a better predictive value for NAFLD than the non-HDL-c and HDL-c in both boys and girls.
Effect of Renal and Left Ventricular Function on Serial Pulmonary Arterial Pressure Changes After Device Closure of Atrial Septal Defect
Authors: Shin Chul , Yoon Young Won , Kim In-Soo , Kim Jong-Youn , Min Pil-Ki , Lee Byoung Kwon , Hong Bum-Kee , Kwon Hyuck Moon , Rim Se-Joong , Choi Eui-Young 
Published: August 2020

Abstract
Background: The age of candidates for device closure of atrial septal defect (ASD) has been increasing. Thus, concerns exist about dyspnea aggravation or atrial fibrillation development after device closure due to augmentation of left ventricular (LV) and left atrial (LA) preload. This study aimed to examine patterns and determinants of serial pulmonary arterial pressure and left ventricular filling pressure changes after device closure of ASD. Methods: Among the 86 consecutive patients who underwent percutaneous device closure of ASD, those without pre- or post-procedural Doppler data and end-stage renal disease were excluded. The clinical, transesophageal, and transthoracic echocardiographic findings of 78 patients were collected at baseline, one day post-procedure, and one year follow-up. Results: The mean age of study patients was 49.8 ± 15.0 years and the average maximal defect diameter and device size was 20.2 ± 6.0 mm and 23.8 ± 6.4 mm. Some patients (n = 21; 27%) exhibited paradoxically increased tricuspid regurgitant velocity (TRV) one-day post-procedure; they also were older with lower e’, glomerular filtration rate, and LV ejection fraction and a higher LA volume index. However, even in these patients, TRV deceased below baseline levels one-year later. Both E/e’ (9.0 ± 3.5 vs. 11.4 ± 4.3; p < 0.001) and LA volume index significantly increased immediately after device closure, but all decreased one-year later. Larger defect size and higher TRV were significantly correlated with immediate E/e’ elevation. Conclusion: In older, renal, diastolic and systolic dysfunctional patients with larger LA, scheduled for larger device implantation, peri-interventional preload reduction therapy would be beneficial.
A Comparative Study of International and Chinese Public Health Emergency Management from the Perspective of Mapping Knowledge Domains
Authors: Li Juan , Zhu Yuhang , Feng Jianing , Meng Weijing , Begma Kseniia , Zhu Gaopei , Wang Xiaoxuan , Wu Di , Shi Fuyan , Wang Suzhen 
Published: August 2020

Abstract
Background: At the end of 2019, the outbreak of the coronavirus disease 2019 (COVID-19) had severely damaging people’s life. China’s public health emergency management system had played an essential role in the handling and response of it, which had been appreciated by the World Health Organization and some countries. Hence it is necessary to make an overall analysis of the development of China’s health emergency management system. It can provide a reference for scholars to understand the current situation and look for new research points. Methods: We collected 2247 international from the Web of Science database, 959 Chinese articles from China National Knowledge Infrastructure database. Bibliometric and mapping knowledge domains analysis methods were used in this study for temporal distribution analysis, cooperation network, co-word network analysis. Results: The first international article in this field was published in 1991, while Chinese in 2005. Research institutions mainly come from universities and health institutions. Developed countries and European countries published more articles, while east of China published more. There are 52 burst words for international articles from 1999–2018, while 18 burst words for Chinese articles from 2003–2018. International top-ranked articles by citation appeared in 2005, 2007, 2009, 2014, 2015, 2016, while Chinese appeared in 2003, 2004, 2009, 2011.Conclusions: There are differences in the regional or economic distribution of international and Chinese cooperation networks. International research often relates to hot issues, mainly focus on the emergency preparedness and monitoring for public health events, while China’s focus on the public health emergency and their disposal. International begins the research with terrorism and bioterrorism, followed by disaster planning and emergency preparedness, epidemics and infectious diseases. China takes severe acute respiratory syndrome as the research background and legal system construction as the research starting point, followed by mechanism, structure, system, and learning from abroad of public health emergency management.