bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consumers’ Sensory Perception of Food Attributes: Identifying the Ideal Formulation of Gluten‐ and Lactose‐Free Brownie Using Sensory Methodologies
Authors: Pio Ávila Bianca , Cardozo Luis Otávio , Alves Gabriela Dutra , Gularte Márcia Arocha , Monks Jander , Elias Moacir Cardoso 
Published: October 2019

AbstractProducts for consumers with special needs (celiac) and those who prefer a differentiated diet are necessary due to growing demand and a niche market to be exploited. The incorporation of other substances in the formulation of cakes requires a detailed analysis of their characteristics and sensorial attributes. However, the use of these flours may change the sensory characteristics of a product that is normally made from wheat flour. This study aimed to identify the ideal formulation of gluten‐ and lactose‐free brownies made with rice flour and beans/lentils in consumer perception, through the combination of sensory tests. Using these data, the aim was to define recommendations for the reformulation of a product of high consumer acceptance, using easily accessible ingredients. The sensory methods used were descriptive analysis with a group of 20 trained evaluators and a group of 100 consumers evaluated through the check‐all‐that‐apply and just‐about‐right questionnaire; all groups performed the acceptance test by hedonic scale. Data were analyzed using multivariate techniques and correlation matrices. The results showed that the attributes selected by the trained evaluators and consumers were sufficient to indicate that color and texture were the most striking characteristics that should be improved in brownie formulations without gluten and lactose.Practical ApplicationThe study assumes that from the combination of sensory methods it is possible to verify the attributes that are most attractive to consumers in gluten‐free and lactose‐free cake formulations, using easily accessible ingredients that have technological, nutritional, and sensory quality, such as those formulated with wheat.
Preventive antibiotic treatment of calves: emergence of dysbiosis causing propagation of obese state‐associated and mobile multidrug resistance‐carrying bacteria
Authors: Dobrzanska Dorota A. , Lamaudière Matthew T. F. , Rollason Jessica , Acton Lauren , Duncan Michael , Compton Sharon , Simms John , Weedall Gareth D. , Morozov Igor Y. 
Published: October 2019

SummaryIn agriculture, antibiotics are used for the treatment and prevention of livestock disease. Antibiotics perturb the bacterial gut composition but the extent of these changes and potential consequences for animal and human health is still debated. Six calves were housed in a controlled environment. Three animals received an injection of the antibiotic florfenicol (Nuflor), and three received no treatment. Faecal samples were collected at 0, 3 and 7 days, and bacterial communities were profiled to assess the impact of a therapy on the gut microbiota. Phylogenetic analysis (16S‐rDNA) established that at day 7, antibiotic‐treated microbiota showed a 10‐fold increase in facultative anaerobic Escherichia spp, a signature of imbalanced microbiota, dysbiosis. The antibiotic resistome showed a high background of antibiotic resistance genes, which did not significantly change in response to florfenicol. However, the maintenance of Escherichia coli plasmid‐encoded quinolone, oqxB and propagation of mcr‐2, and colistin resistance genes were observed and confirmed by Sanger sequencing. The microbiota of treated animals was enriched with energy harvesting bacteria, common to obese microbial communities. We propose that antibiotic treatment of healthy animals leads to unbalanced, disease‐ and obese‐related microbiota that promotes growth of E. coli carrying resistance genes on mobile elements, potentially increasing the risk of transmission of antibiotic resistant bacteria to humans.
Haloperidol for the treatment of delirium in critically ill patients: A systematic review with meta‐analysis and Trial Sequential Analysis
Authors: Barbateskovic Marija , Krauss Sara R. , Collet Marie O. , Andersen‐Ranberg Nina C. , Mathiesen Ole , Jakobsen Janus C. , Perner Anders , Wetterslev Jørn 
Published: October 2019

BackgroundHaloperidol is the most frequently used drug to treat delirium in the critically ill patients. Yet, no systematic review has focussed on the effects of haloperidol in critically ill patients with delirium.MethodsWe conducted a systematic review with meta‐analysis and Trial Sequential Analysis of randomized clinical trials (RCTs) assessing the effects of haloperidol vs any intervention on all‐cause mortality, serious adverse reactions/events, days alive without delirium, health‐related quality of life (HRQoL), cognitive function and delirium severity in critically ill patients with delirium. We also report on QTc prolongation, delirium resolution and extrapyramidal symptoms.ResultsWe included 8 RCTs with 11 comparisons (n = 951). We adjudicated one trial as having overall low risk of bias. Three trials used rescue haloperidol; excluding these, we did not find an effect of haloperidol vs control on all‐cause mortality (RR 1.01; 95% CI 0.33‐3.06; I2 = 0%; 112 participants; 3 trials; 4 comparisons; very low certainty) or delirium severity (SMD −0.15; 95% CI −0.61‐0.30; I2 = 27%; 134 participants; 3 trials; 4 comparisons; very low certainty). No trials reported adequately on serious adverse reactions/events. Only one trial reported on days alive without delirium, cognitive function and QTc prolongation, and no trials reported on HRQoL. Sensitivity analyses, including trials using rescue haloperidol, did not change the results.ConclusionsThe evidence for the use of haloperidol to treat critically ill patients with delirium is sparse, of low quality and inconclusive. We therefore have no certainty regarding any beneficial, harmful or neutral effects of haloperidol in these patients.
A thing of the past? Household surveys in a rapidly evolving (agricultural) data landscape: Insights from the LSMS‐ISA
Authors: Carletto Calogero , Gourlay Sydney 
Published: October 2019

AbstractHousehold surveys, a pivotal component of every country's national statistical system, continue to be criticized and praised in equal manner. While recognizing their limitations, it is clear that certain types of data must continue to be collected through household surveys, preferably in an integrated manner with other data sources. This is particularly true in the agricultural space for which household and farm surveys will be critical both to collect primary data as well as to validate alternative data sources. Recent methodological gains and technological innovations offer a unique opportunity to address many of the shortcomings of agricultural data. In this article, we briefly describe select examples of such methodological and technological changes, drawing from the Living Standards Measurement Study‐Integrated Surveys on Agriculture, a survey program aimed at improving the availability, quality, and relevance of agricultural data in multitopic, multipurpose household surveys.
The Mobilizing Effect of Parties' Moral Rhetoric
Authors: Jung Jae‐Hee 
Published: October 2019

AbstractHow does parties' use of moral rhetoric affect voter behavior? Prior comparative party research has studied party positions without much attention to how parties explain and justify their positions. Drawing insights from political and moral psychology, I argue that moral rhetoric mobilizes copartisan voters by activating positive emotions about their partisan preference. I expect this to hold among copartisans who are exposed to party rhetoric. To test my argument, I measure moral rhetoric by text‐analyzing party manifestos from six English‐speaking democracies and measure mobilization using copartisan turnout in survey data. The results support my argument. Furthermore, I find evidence in support of the theoretical mechanism using survey experiments and panel survey data from Britain. The article shows that moral rhetoric is a party campaign frame that has important consequences for voter behavior.
Evaluation of different Swept’Source optical coherence tomography angiography (SS‐OCTA) slabs for the detection of features of diabetic retinopathy
Authors: Tian Meng , Wolf Sebastian , Munk Marion R. , Schaal Karen B. 
Published: October 2019

AbstractPurposeTo compare different Swept‐Source optical coherence tomography angiography (SS‐OCTA) slabs for the detection of features of diabetic retinopathy (DR), to find the most suitable slab for grading.MethodsRetrospective cross‐sectional study. Consecutive patients with DR were evaluated using SS‐OCTA. The central 12 × 12 mm scan was used to generate the retinal, superficial and deep slab. The grading results of the slabs were then compared to determine if one specific slab is superior to detect respective features.ResultsA total of 348 eyes (190 patients; mean age 58.1 ± 14.5 years) were graded for features of DR. The retinal slab detected most frequently MAs and IRMAs, however with no significant difference compared to the superficial slab (p = 0.93 and p = 0.93, respectively). Small capillary dropout was most frequently found on the superficial slab, but there was no significant difference compared with the retinal (p = 0.78) and deep slab (p = 0.45). The only statistically significant difference was found for large capillary dropout, where the retinal and superficial slab showed a higher detection rate compared with the deep slab (p ≤ 0.0001 and p = 0.001, respectively).ConclusionsThe superficial and retinal slabs are equally suitable for grading with no statistically significant difference in the detection rate of the diabetic features examined.
Patterns That Challenge and Sustain Mutuality as Retired Couples Negotiate Gendered Power
Authors: Nice Lindsey , Knudson‐Martin Carmen , Lough Aubrey , Castillo Nakisha , Doe Kimberly 
Published: October 2019

ObjectiveTo examine how older, heterosexual couples negotiate gendered power when both partners are retired.BackgroundAfter retirement, changes frequently prompt couples to renegotiate traditional, gender‐informed ways of relating. Although a shift toward less gender‐specific division of tasks has been identified in previous studies, it is unclear how underlying gendered power structures may also be transformed.MethodA constructivist grounded theory analysis was conducted of 18 interviews with a convenience sample of retired older couples (69–91 years of age) in Southern California.ResultsThree patterns were identified that kept couples engaged in stereotypic gendered processes: (a) women's relational responsibility, (b) masked inequality, and (c) men's marketing of traditional gender‐specific processes. In addition, four patterns were identified that moved couples closer to mutuality: (a) equal attunement to one another, (b) mutual decision‐making, (c) connecting with socioemotional context, and (d) recognition of inequality.ConclusionRetired couples seeking relational help may be experiencing a gap between ideals of mutuality and the persistence of gendered power.ImplicationsThis study shows that gendered power dynamics may be somewhat masked among older couples. Practitioners are advised to address the subtle ways that relational dynamics may remain gendered and the extent to which that limits closeness and connection within the relationship. Specific areas therapists should explore with clients are provided.
The crystal structure of the naturally split gp41‐1 intein guides the engineering of orthogonal split inteins from cis‐splicing inteins
Authors: Beyer Hannes M. , Mikula Kornelia M. , Li Mi , Wlodawer Alexander , Iwaï Hideo 
Published: October 2019

Protein trans‐splicing catalyzed by split inteins has increasingly become useful as a protein engineering tool. We solved the 1.0 Å‐resolution crystal structure of a fused variant from the naturally split gp41‐1 intein, previously identified from environmental metagenomic sequence data. The structure of the 125‐residue gp41‐1 intein revealed a compact pseudo‐C2‐symmetry commonly found in the Hedgehog/Intein superfamily with extensive charge–charge interactions between the split N‐ and C‐terminal intein fragments that are common among naturally occurring split inteins. We successfully created orthogonal split inteins by engineering a similar charge network into the same region of a cis‐splicing intein. This strategy could be applicable for creating novel natural‐like split inteins from other, more prevalent cis‐splicing inteins.DatabaseStructural data are available in the RCSB Protein Data Bank under the accession number 6QAZ.
Damage behaviour of laminated composites during fatigue loading
Authors: Mahmoudi Ali , Mohammadi Bijan , Hosseini‐Toudeshky Hossein 
Published: October 2019

AbstractThis study deals with the modelling of damage evolution in the carbon/epoxy laminated composites under static and fatigue loading. A cumulative damage model is developed on the basis of damage evolution due to static and fatigue during cyclic loading. A continuum damage mechanics (CDM)‐based damage model coupling with the micromechanics has been utilized to predict the fatigue behaviour of laminate composites. A multicriterion approach has been introduced to predict the damage behaviour in the longitudinal, transverse, and shear direction at the ply scale. Extensive experimental results on T300/EPL1012 carbon/epoxy laminates are prepared to characterize under static and fatigue loading and to evaluate the proposed model in different conditions. The obtained results show that at the beginning of the cyclic loading, the damage grows suddenly and increases until final failure, which justifies the proposed method is able to predict the evolution of the damage due to static and fatigue loading separately during cyclic loading. The obtained results show that considering damage due to static loading leads to more accurate results, particularly in low‐cycle fatigue.
Pyoderma gangrenosum at multiple sites in a post‐colostomy ulcerative colitis patient with chronic hepatitis B virus: A case report
Authors: Wang Ben , Liu Ting , Liu Fang , He Yan‐Ling 
Published: October 2019

AbstractPyoderma gangrenosum is an uncommon ulcerative cutaneous lesion manifesting as rapidly progressing single or multiple skin ulcers. Permanent stoma in inflammatory bowel disease patients remains an independent risk of pyoderma gangrenosum. In the current report, we describe a case of pyoderma gangrenosum in a post‐colostomy ulcerative colitis patient with chronic hepatitis B. Pyoderma gangrenosum began seemingly as peristomal dermatitis that rapidly developed into painful ulcerations with subsequent appearance of sterile pustules and ulcerations in the left lower leg. The patient significantly improved after active management with prednisolone, antiviral therapy with entecavir, and wound dressings. Our case suggests that physicians and surgeons should have a high index of suspicion of pyoderma gangrenosum in post‐colostomy ulcerative colitis patients who develop peristomal dermatitis.
Cyclic AMP‐dependent positive feedback signaling pathways in the cortex contributes to visceral pain
Authors: Liu Shui‐bing , Wang Xin‐shang , Yue Jiao , Yang Le , Li Xu‐hui , Hu Li‐ning , Lu Jing‐shan , Song Qian , Zhang Kun , Yang Qi , Zhang Ming‐ming , Bernabucci Matteo , Zhao Ming‐gao , Zhuo Min 
Published: October 2019

AbstractCortical areas including the anterior cingulate cortex (ACC) play critical roles in different types of chronic pain. Most of previous studies focus on the sensory inputs from somatic areas, and less information about plastic changes in the cortex for visceral pain. In this study, chronic visceral pain animal model was established by injection with zymosan into the colon of adult male C57/BL6 mice. Whole cell patch‐clamp recording, behavioral tests, western blot, and Cannulation and ACC microinjection were employed to explore the role of adenylyl cyclase 1 (AC1) in the ACC of C57/BL6 and AC1 knock out mice. Integrative approaches were used to investigate possible changes of neuronal AC1 in the ACC after the injury. We found that AC1, a key enzyme for pain‐related cortical plasticity, was significantly increased in the ACC in an animal model of irritable bowel syndrome. Inhibiting AC1 activity by a selective AC1 inhibitor NB001 significantly reduced the up‐regulation of AC1 protein in the ACC. Furthermore, we found that AC1 is required for NMDA GluN2B receptor up‐regulation and increases of NMDA receptor‐mediated currents. These results suggest that AC1 may form a positive regulation in the cortex during chronic visceral pain. Our findings demonstrate that the up‐regulation of AC1 protein in the cortex may underlie the pathology of chronic visceral pain; and inhibiting AC1 activity may be beneficial for the treatment of visceral pain.
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Solutions to dental access disparity: Blueprint of an innovative community health center‐based model for rurally based communities
Authors: Nycz Gregory , Acharya Amit , Glurich Ingrid 
Published: October 2019

AbstractDr. David Satcher issued the first Surgeon General Report on oral health in the United States in 2000, drawing attention to a prevailing oral health access crisis. Dr. Satcher's report resonated in Wisconsin where a statewide growing dental access crisis was in progress and inspired grassroots efforts by a Family Health Center to establish a practice‐based multi‐site dental infrastructure that was integrated into a large regional multi‐specialty medical clinic serving a largely rural population. An overview is provided of fundamental elements and relationships that supported establishment of the infrastructure, services, outreach and expanded access offered inclusively to all patients. Further, this community action report presents a blueprint that delineates key dimensions critical to planning and establishing a regionalized infrastructure offering access to all patients. Feasibility of establishing inclusive dental care is documented, and our model is proposed as a potentially replicable prototype for increasing dental access across other federally qualified health centers. Finally, this report is responsive to Dr. Jerome Adam's solicitations for feedback that will inform his plan for issuing a new Surgeon General report that updates status of oral health in America and progress in reversing oral health access disparities.
A mixed model of the evolution of polygyny and sexual size dimorphism in mammals
Authors: Cassini Marcelo H. 
Published: October 2019

AbstractThe theory of sexual selection is the most widely accepted theory explaining the evolution of mating systems and secondary sexual characters. Polygyny is the most common mating system in mammals, and there is a strong correlation between the degree of polygyny and the degree of sexual size dimorphism skewed towards males. Sexual selection theory posits that polygyny in mammals has evolved through direct, precopulatory, intrasexual selection in males, and that sexual size dimorphism is a result of male competition for mates. New results that are being obtained with the use of molecular techniques and with comparative phylogenetic methods do not appear to support predictions from this classical model in full. In this article, an expansion of the classical model is presented that combines the effects of at least four forms of selection: natural, precopulatory intrasexual, postcopulatory intrasexual, and intersexual selection. This mixed model consists of an initial phase in which natural selection operates on body size, followed by a second phase dominated by sexual selection and involving increases in sexual dimorphism and coercive behaviour of males towards females. Sexual harassment induces female aggregation, thus creating social potential for polygyny. Males compete for access to the groups of females, following two possible evolutionary scenarios, directional or equilibrium sexual selection, both producing similar behavioural polygyny, but with differences in the intensity of intra‐male precopulatory sexual selection. Predictions of the mixed model are as follows: 1) polygyny can exist without high variance in male reproductive success (a fundamental requirement in the classical model); 2) extra‐group fertilisation can be common; 3) sexual size dimorphism evolved prior to polygyny; 4) sexual coercion is widespread; and 5) females reduce levels of sexual coercion by joining groups.
Current and future impacts of nest predation and nest‐site competition by invasive eastern grey squirrels Sciurus carolinensis on European birds
Authors: Broughton Richard K. 
Published: October 2019

Abstract

The eastern grey squirrel (hereafter ‘grey squirrel’) is considered one of the most damaging invasive alien species in Europe, with negative effects on native ecosystems. Despite it being widely perceived as a significant predator of bird eggs and chicks and as a competitor for nest sites, evaluation of the grey squirrel’s impact on European bird populations has been hindered by limited empirical data.

The aim was to review the incidence of grey squirrels as nest predators of and nest‐site competitors with European birds, and to use this information to identify species at potential risk of negative effects from within the grey squirrel’s expanding range in continental Europe.

A comprehensive literature review was conducted, and the data were used alongside additional new data, to assess nest predation and competition by grey squirrels in their current European range. Bird species were grouped by nest‐site type, which was used to predict the impact on similar species groups in regions of continental Europe predicted to be colonised by grey squirrels in the current century.

Camera‐monitoring and field evidence for 12 bird species and 12420 nests in Britain showed that grey squirrels rarely depredated eggs or chicks, affecting just 0.5% of nests. Nest‐site competition was also minor, with grey squirrels occupying 0.8% of 122 small tree cavities and 14% of 57 larger cavities. At least 69 bird species in continental Europe could be exposed to potential nest predation or competition from expanding grey squirrel populations within the current century, but population‐level effects currently appear to be unlikely.

Current evidence shows that grey squirrels are unlikely to be significant predators of or competitors with nesting birds in their present or projected range in Europe. However, further studies of more species in different regions would be valuable, particularly in urban and suburban habitats.
Inference for Biomedical Data by Using Diffusion Models with Covariates and Mixed Effects
Authors: Ruse Mareile Große , Samson Adeline , Ditlevsen Susanne 
Published: October 2019

SummaryNeurobiological data such as electroencephalography measurements pose a statistical challenge due to low spatial resolution and poor signal-to-noise ratio, as well as large variability from subject to subject. We propose a new modelling framework for this type of data based on stochastic processes. Stochastic differential equations with mixed effects are a popular framework for modelling biomedical data, e.g. in pharmacological studies. Whereas the inherent stochasticity of diffusion models accounts for prevalent model uncertainty or misspecification, random-effects model intersubject variability. The two-layer stochasticity, however, renders parameter inference challenging. Estimates are based on the discretized continuous time likelihood and we investigate finite sample and discretization bias. In applications, the comparison of, for example, treatment effects is often of interest. We discuss hypothesis testing and evaluate by simulations. Finally, we apply the framework to a statistical investigation of electroencephalography recordings from epileptic patients. We close the paper by examining asymptotics (the number of subjects going to ∞) of maximum likelihood estimators in multi-dimensional, non-linear and non-homogeneous stochastic differential equations with random effects and included covariates.