bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associação dos principais parâmetros hematológicos, bioquímicos e imunológicos em pacientes graves e não graves com COVID-19: uma revisão sistemática
Authors: Souza Karolayne Silva , Silva Milena Roberta Freire da , Silva Sivoneide Maria da , Oliveira Maria Betânia Melo de , Lima Ana Vitória Araújo , Sá Rafael Artur de Queiroz Cavalcanti de , Ramos Bárbara de Azevedo , Silva Jaqueline dos Santos , Santos Graziele dos , Lima Felicson Leonardo Oliveira , Silva Rodrigo Reges dos Santos , Brito Leandro Paes de 
Published: November 2020

Introdução: A COVID-19 é uma doença infectocontagiosa causada pelo vírus SARS-CoV-2, responsável por acometer principalmente os pulmões e desencadear patologias respiratórias, como também desenvolver problemas hepáticos, neurológicas e gastrointestinais. O objetivo desta revisão sistemática foi realizar um levantamento de estudos com os principais marcadores laboratoriais de pacientes com COVID-19 relacionando as anormalidades destes resultados com a predição clínica de pacientes graves e não graves. Metodologia: Este estudo foi conduzido seguindo as diretrizes metodológicas de uma Revisão Sistemática de acordo com o protocolo PRISMA, dos quais, realizou-se buscas nas bases eletrônicas PubMed, LILACS, EMBASE, Science, medRxiv, e bioRxiv, utilizando as palavras-chaves: "SARS-CoV-2" OR "COVID-19" OR "Coronavirus" AND “Laboratory Parameters” AND "Exams" OR "Laboratory". Foram utilizados artigos elegíveis publicados a partir de janeiro de 2020 até 20 de maio de 2020, sem restrições de idioma contendo dados laboratoriais hematológicos, bioquímicos e imunológicos. Resultados: De acordo com esta revisão foram selecionados 16 artigos elegíveis. As principais anormalidades foram observadas em pacientes graves com alterações expressivas em alguns parâmetros hematológicos, bioquímicos e imunológicos, sendo estes: ferritina, linfócitos, D-Dímero, LDH, AST, PCR, Procalcitonina, TcnI e IL-6. Conclusão: O presente estudo demonstra a relevância dos exames laboratoriais para auxiliar os profissionais da área da saúde na execução de medidas necessárias e condutas terapêuticas adequadas para o tratamento de pacientes infectados pelo coronavírus.
Análise do Hardiness elevado de profissionais de enfermagem de um hospital universitário
Authors: Barreto Valéria Paes de Castro , Ferreira Simone Cruz Machado , Correia Dayse Mary da Silva 
Published: November 2020

Introdução: o hardiness pode ser definido como uma estratégia de enfrentamento ao estresse ocupacional e apoio à prevenção da Síndrome de Burnout. Objetivo: analisar os escores altos de hardiness dos profissionais de enfermagem de um hospital universitário. Metodologia: estudo observacional, transversal e descritivo, de abordagem quantitativa, cuja amostra foram 171 profissionais de enfermagem em contexto hospitalar, no período de abril a outubro de 2016. Para coleta de dados utilizou-se a Escala hardiness, tipo Likert, composta por 30 itens, distribuídos entre três dimensões: desafio, compromisso e controle, variando de 0 a 90 pontos. Resultado: dos 171 participantes, houve predominância do sexo feminino 136 (79,5%) e média de idade de 45 anos. Na análise da média geral dos escores, os enfermeiros tiveram maior média no compromisso (22,4), enquanto no controle, os enfermeiros e os técnicos de Enfermagem obtiveram a mesma pontuação (21,5). E por fim, no desafio, o enfermeiro pontuou mais baixo que as demais categorias (14,3). Conclusão: entre as categorias da equipe de enfermagem houve diferença de pontuação dos escores altos nas três dimensões da Escala Hardiness.
Perspectivas da intersetorialidade no cotidiano da Atenção Primária à Saúde no Brasil: uma reflexão teórica
Authors: Mendonça Edna Mara , Lanza Fernanda Moura 
Published: November 2020

Objetivo: refletir sobre as perspectivas da intersetorialidade no cotidiano da Atenção Primária à Saúde no Brasil. Método: trata-se de reflexão teórica a partir de pesquisa bibliográfica para embasamento teórico. O estudo teve como disparador o questionamento: Quais são as perspectivas das práticas intersetoriais realizadas nos serviços de Atenção Primária à Saúde? Resultados: A reflexão foi organizada em duas seções: (1) A concepção ampliada de saúde e a promoção do cuidado na dimensão intersetorial. Enfatiza a importância da intersetorialidade ao fomentar a produção do cuidado e ampliar a realidade local ao integrar conhecimentos, setores, atores, pois extrapola a atuação do setor saúde. (2) Tessituras do Trabalho em Saúde na Atenção Primária com articulação intersetorial. Aponta os desafios de produzir saúde no cotidiano dos serviços ao demandar constantes mudanças no processo de trabalho como a criação de coletivos e parcerias de diferentes atores sociais, o que imprime uma lógica de organização do trabalho para a superação da exclusão e iniquidades em saúde. Conclusão: a intersetorialidade tem sido colocada como favorecedora das políticas de saúde voltadas para a mudança de modelos de atenção pois, representa a superação da fragmentação das políticas, além de ser uma ferramenta de colaboração das práticas de cuidado e/ou gestão.
Analgesic Effect Comparison Between Nalbuphine and Sufentanil for Patient-Controlled Intravenous Analgesia After Cesarean Section
Authors: Sun Shen , Guo Yundong , Wang Tingting , Huang Shaoqiang 
Published: November 2020

Background: Efficient maternal pain relief after cesarean delivery remains challenging, but it is important to improve outcomes for the mother and the newborn during the puerperium. We compared the analgesic effect of nalbuphine (a κ receptor agonist/μ receptor antagonistic) with that of sufentanil (a µ-receptor agonist) in patient-controlled intravenous analgesia (PCIA) after cesarean section.Methods: We enrolled 84 patients scheduled for elective cesarean sections with spinal anesthesia and randomized them into either nalbuphine or sufentanil groups (42 patients each). Pain scores, PCIA drug consumptions, degree of satisfaction, and adverse events were recorded as outcome measures.Results: The pain scores at rest and uterine cramping pain scores in the nalbuphine group were lower than those in the sufentanil group at 6, 12, and 24 h after the operation. Also, the pain scores while switching to a seated position were lower in the nalbuphine group than in the sufentanil group at 6 and 12 h after the operation (p &lt; 0.05). We found no significant differences in the PCIA drug consumption between the two groups. The degree of satisfaction in patients in the nalbuphine group was higher than that of patients in the sufentanil group (p = 0.01). Adverse events did not differ in the two groups.Conclusion: PCIA with nalbuphine provides better analgesia and higher patient satisfaction than sufentanil after cesarean section.
Analysis of the consumption of antibacterial medications in community-acquired pneumonia in children
Authors: Chepurnova A. I. , Eliseeva E. V. , Feoktistova Yu. V. , Kropotov A. V. 
Published: November 2020

Objective: The study objective is to analyze the efficacy of antibacterial medication selection to treat community-acquired pneumonia (CAP) in children in an out-patient clinic and in a pulmonology department of an in-patient hospital.Methods: Retrospective descriptive study for 2009–2017 in day-patient departments of pediatric clinics and pediatric pulmonology departments of in-patient hospitals of Primorskiy territory (760 cases).Results: 50 % of children took antibiotics at pre-hospital stage (self-treatment). Penicillins were the most popular – 50.1 % (218 prescriptions), cephalosporins were used in 129 (29.7 %), macrolides – in 86 (18.8 %) of cases. The average duration of antibacterial treatment course of CAP was 10 days at pre-hospital stage. Both in the out-patient clinic and in the in-patient hospital, cephalosporins (58.4 and 58.3 %), macrolides (34.8 and 37.4 %) and aminoglycosides (6.3 and 3.4 %) were used more often.Conclusions: The positive dynamics in the protocols of antibiotic therapy of CAP should be noted. The improvement of regulatory framework has led to the increase of rational prescriptions. It is necessary to continue improving of clinical guidelines and implementing pulmonology hospitals of microbiological monitoring that will allow improving the quality of antibacterial treatment.
Negative pressure therapy for management of patients with enterocutaneous fistulas
Authors: Demko A. E. , Batyrshin I. M. , Ostroumova J. S. , Sklizkov D. S. , Fomin D. V. 
Published: November 2020

Objective:To assess the benefits of negative pressure wound therapy (NPWT) in complex therapy of patients with enterocuta‑ neous fistulas.Methods: From 2014 to 2019 in Saint Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine, 24 patients were managed with vacuum assisted techniques. For comparison, a comparable group of 23 observations (control) was formed retrospectively based on an analysis of medical records.Results: When using NPWT, the terms of wound cleansing and the formation of a laparostomy were reduced, and conditions were created for its early closure. With a small laparostomy, the use of NPWT contributed to self-epithelialization of the wound around the fistula.Conclusions: The use of NPWT more than halves the time of formation of a laparostomy, shortens the time for cleansing the wound and creates the conditions for its closure. Surgical tactics using NPWT can more than three times reduce the number of local complications in patients with unformed intestinal fistulas and less often change the combination of antibacterial drugs.
Personalized approach to the treatment of metastatic kidney cancer
Authors: Alrkseeva G. N. , Gurina L. I. , Pisareva L. F. , Volkov M. V. , Cherdyntseva N. V. 
Published: November 2020

Objective: Develop a new organizational form of a personalized approach to assign a target therapy to the patients with metastatic nephrocellular cancer concerning its clinical and economic effectiveness.Methods: The data by cancer register of the Primorsky region were used. 446 patients are included in the register, it allowed to estimate clinical-economic effectiveness of the target therapy by studying 88 cases.Results: 5 medicines were used: sunitrib, soraphenib, bevazizumab, everolimus and pazopanib. The control of the progress of the disease and the toxicity covered 44,3% of the patients. The toxicity of the 3–4th levels were registered during the treatment by inhibitors tyrozinkinaz. The target line therapy increased expenditures by 10% and allowed to increase overall survivability to 42 months.Conclusion: An electronic register of the patients provides monitoring, optimizes expenditures and increases the availability of the target therapy up to 19,7%. Sequential therapy is reasonable and provides the increase of the overall patients’ survivability.
efektivitas metode filtrasi dan adsorpsi dalam menurunkan kesadahan air sumur di kecamatan kota baru kota jambi
Authors: Husaini Ahmad , Yenni Melda , Wuni Cici 
Published: November 2020

Penggunaan air dengan kesadahan tinggi dan pH tidak netral dapat mengakibatkan kerusakan pada peralatan rumah tangga dan juga akan mengakibatkan gangguan kesehatan seperti cardiovascular desease dan urolithalisis. Air sumur yang digunakan masyarakat di wilayah kerja Kecamatan Kota Baru Kota Jambi memiliki kesadahan yang tinggi dengan ciri-ciri menimbulkan kerak pada peralatan masak, endapan warna putih pada tempat penampungan air.Penelitian ini bertujuan untuk mengetahui pengaruh metode filtrasi dan adsorpsi terhadap derajat pH air dan tingkat kesadahan air.Penelitian ini merupakan penelitian Quasi Eksperimen dengan rancangan time series design. Sampel penelitian ini yaitu air sumur. Pengambilan data dengan melakukan pengukuran pH menggunakan pH meter dan kesadahan air dengan metode titrimetri. Data di analisis dengan cara melihat perubahan derajat keasaman (pH) dan persentase perubahan kesadahan air.Hasil penelitian menunjukkan pH air sebelum pengolahan yaitu 4 dan meningkat pada lama kontak <1 menit menjadi 6,2, 6,5 pada lama kontak 30 menit, 6,3 pada lama kontak 60 menit, 6,2 pada lama kontak 90 menit dan 6,7 pada lama kontak 120 menit. Persentase penurunan kesadahan air pada waktu kontak <1 menit sebesar 7,14%, lama kontak 30 menit sebesar 15,35%, lama kontak 60 menit sebesar 36,42%, lama kontak 90 menit sebesar 38,57% dan lama kontak 120 menit sebesar 62,85%.Terdapat peningkatan derajat pH air sumur dan penurunan tingkat kesadahan air sumur setelah dilakukan pengolahan dengan cara filtrasi dan adsorpsi. Semakin lama kontak dalam proses filtrasi dan adsorpsi akan semakin efektif terhadap peningkatan pH air sumur dan penurunan tingkat kesadahan air sumur.
faktor-faktor yang berhubungan dengan perilaku mahasiswa dalam penggunaan plastik dan styrofoam untuk pembungkus makanan di fakultas kesehatan universitas mitra indonesia tahun 2020
Authors: Utami Alun Mega yuni , Listina Febria , Novariana Nana 
Published: November 2020

Data Asosiasi Industri Plastik Indonesia (INAPLAS) dan Badan Pusat Statistik (BPS) menginformasikan sampah plastik di Indonesia mencapai 64 juta ton per tahun 3,2 juta ton sampah plastik dibuang ke laut, serta ke lingkungan sebanyak 85.000 ton. Dinas Lingkungan Hidup Lampung, produksi sampah di Lampung mencapai 7.000 ton/hari. Tujuan penelitian ini untuk dilakukan untuk mengetahui Faktor - Faktor Yang Berhubungan Dengan Perilaku Mahasiswa Dalam Penggunaan Plastik Dan Styrofoam Untuk Pembungkus Makanan di Fakultas Kesehatan Universitas Mitra Indonesia .Penelitian dilakukan pada tanggal 8 – 18 Juni tahun 2020. Subjek penelitian mahasiswa fakultas kesehatan, populasi 956 dan sampel sebanyak 282 mahasiswa. Penelitian kuantitatif bersifat survai analitik desain cross sectional. Analisis menggunakan univariat dan bivariat uji chi-squere. Hasil penelitian tidak ada hubungan pengetahuan (p value sebesar 0,657) dan peran orang tua (p value sebesar0,959) serta terdapat hubungan sikap (p value0,005, OR = 2,024) terhadap perilaku penggunaan plastik dan styrofoam untuk pembungkus makanan. Diharapkan Universitas Mitra Indonesia melakukan kegiatan advokasi, penyuluhan kesehatan tentang bahaya penggunaan plastik dan styrofoam bagi kesehatan serta pemberian leatflet, poster dan contoh pengganti kemasan styrofoam dan plastik.
dampak penggunaan internet terhadap perkembangan fisik remaja pada masa pandemi covid-19 di kota malang
Authors: Alfitri Rosyidah , Widiatrilupi Raden Maria veronika 
Published: November 2020

Saat ini dunia sedang mengalami pandemi Covid-19 termasuk di Indonesia. Pemerintah Indonesia menerapkan physical distancing untuk menghambat penyebaran Covid-19, hal ini juga berlaku bagi seluruh individu termasuk remaja. Proses pendidikan yang dilakukan jarak jauh akan membuat remaja menggunakan sarana internet. Penggunaan internet yang terus menerus juga akan berdampak pada perkembagan fisik remaja atau kesehatannya. Penelitian ini bertujuan untuk menganalisis pengaruh durasi penggunaan internet terhadap perkembangan fisik remaja pada masa pandemi Covid-19. Metode penelitian yang digunakan adalah analitik dengan pendekatan cross sectional. Responden terdiri dari 236 remaja di 2 kelurahan yaitu kelurahan Tanjung Rejo dan Kasin Kota Malang. Pengambilan sampel dengan simple random sampling. Analisis data menggunakan uji chi square.Hasil dari penelitian ini didapatkan remaja menggunakan internet dengan durasi lebih dari 7 jam. Dampak perkembangan fisiknya dinyatakan berdampak atau mengalami dampak kesehatan berjumlah 67 remaja. Hasil dari uji chi square didapatkan nilai p= 0,000 yang artinya ada pengaruh atau ada kaitannya durasi penggunaan internet dengan perkembangan fisik. Semakin lama penggunaan internet semakin mempengaruhi perkembangan fisik remaja maka dari itu orang tua remaja harus lebih bijak dan membatasi dalam penggunaan internet agar tidak terjadi gangguan perkembangan fisik atau kesehatannya.
Formation of population gene pools of zoonotic viruses, potentially threatening biosafety
Authors: Lvov D. K. , Gulyukin M. I. , Zaberezhniy A. D. , Gulyukin A. M. 
Published: November 2020

The possible formation of population gene pools of zoonotic viruses with a respiratory route of transmission and a possibility of a pandemic at different stages of biosphere evolution is analyzed. Forming of Poxviruses (Entomopoxvirinae) gene pool could be the beginning of transformation from Plants to Arthropoda (Carbon – 375 million years ago) with further evolution connected with Rodentia (Pliocene – 75–70 million years ago) and further separation of genera (500–300 thousand years ago), and respiratory transmission (epidemics) between humans (10–2 thousand years BC). Smallpox comeback would be possible. Orthomyxoviruses relicts (genus Isavirus) were possibly connected with Ichthya (Silurian – 500–410 million years ago), and then close interaction with Aves (the Cretaceous, 125–110 million years ago) with the division of genera and respiratory transmission (epidemics) between humans (10–2 thousand BC). Next pandemic of influenza A could be catastrophic in terms of the number of victims and economic damage.Coronaviruses formed a gene pool by interaction with Amphibia (subfamily Letovirinae) and then with Chiroptera in Tertiary (110–75 million years ago) with transformation to Artiodactyla (Eocene – 70–60 million years ago), and only 10–2 thousand years BC acquired the ability to a respiratory transmission and became Alphaviruses, a seasonal infection of humans. A similar situation is possible in the near future with SARS-CoV-2. Pandemics associated with zoonoses even more serious than COVID-19 are likely. Constant monitoring of populational gene pools of zoonotic viruses is necessary.
Analysis of human coronaviruses circulation
Authors: Yatsyshina S. B. , Mamoshina M. V. , Shipulina O. Yu. , Podkolzin A. T. , Akimkin V. G. 
Published: November 2020

Introduction. The novel SARS-CoV-2 coronavirus, which emerged at the end of 2019 and caused a worldwide pandemic, triggered numerous questions about the epidemiology of the novel COVID-19 disease and about wellknown coronavirus infections, which used to be given little attention due to their mild symptoms.The purpose: The routine screening-based multiyear retrospective observational study of prevalence and circulation patterns of epidemic-prone human coronaviruses in Moscow.Material and methods. The real-time polymerase chain reaction was used to detect RNA of human coronaviruses (HCoVs) in nasal and throat swabs from 16,511 patients with an acute respiratory infection (ARI), aged 1 month to 95 years (children accounted for 58.3%) from January 2016 to March 2020, and swabs from 505 relatively healthy children in 2008, 2010 and 2011. Results. HCoVs were yearly found in 2.6–6.1% of the examined patients; the detection frequency was statistically higher in adults than in children, regardless of sex. At the height of the disease incidence in December 2019, HCoVs were detected in 13.7% of the examined, demonstrating a two-fold increase as compared to the multi-year average for that month. The statistical frequency of HCoV detection in ARI pediatric patients under 6 years was significantly higher than in their healthy peers (3.7 vs 0.7%, p = 0.008).Conclusion. HCoVs circulate annually, demonstrating a winter-spring seasonal activity pattern in the Moscow Region and reaching peak levels in December. Over the years of observation, the HCoV epidemic activity reached maximum levels in December 2019–February 2020 and decreased in March to the multi-year average. Amid a growing number of SARS-CoV-2 cases imported to Moscow in March 2020, the HCoV detection frequency dropped sharply, which can be explained by the competition between different coronaviruses and by the specificity of HCoV detection with the diagnostic test kit used in this study.
A Educação pela Pesquisa como abordagem facilitadora da argumentação dialógica
Authors: Borges Thelma Duarte Brandolt , Lima Valderez Marina do Rosário 
Published: November 2020

O presente artigo constitui um recorte de uma pesquisa realizada em nível de doutorado e que tem a argumentação em sala de aula como escopo central. A partir de entendimentos decorrentes de uma aproximação com o tema e do reconhecimento de seu aspecto nebuloso e complexo, emergiu o delineamento dessa investigação. Tal delineamento partiu de um olhar voltado a abordagens que reconhecem a pesquisa como princípio pedagógico e que, portanto, valorizam os processos argumentativos para a reconstrução do conhecimento. Envolveu, ainda, a indicação de escolha por uma perspectiva de ênfase para o estudo e o desenvolvimento da argumentação por meio da apresentação de três perspectivas possíveis, quais sejam: a lógica, a retórica e a dialógica. Definidos esses marcos, estabeleceu-se como objetivo central desse estudo avaliar o processo de construção de argumentos desenvolvido por meio da Educação pela Pesquisa à luz de distintas vertentes argumentativas. Em termos metodológicos, o estudo caracterizou-se como qualitativo, de natureza teórica. Nele, foi produzida a tessitura de um arcabouço teórico que procurou evidenciar distanciamentos e pontos de contato entre as principais vertentes argumentativas e os pressupostos da Educação pela Pesquisa. Os resultados revelaram aproximações com a perspectiva dialógica, conduzindo à conclusão de que a concepção, a intencionalidade e a operacionalização da argumentação desenvolvida por meio da Educação pela Pesquisa associam-se à vertente dialógica do tema.
EFESIENSI BIAYA DISTRIBUSI DENGAN JARAK DAN WAKTU TEMPUH TERHADAP KAPASITAS GUDANG
Authors: Sumiyanto Sumiyanto Sumiyanto 
Published: November 2020

ABC is a system integrator company engaged in the field of information technology in Jakarta. ABC company is provides information technology solutions to customers in the form of hardware and software. ABC’s company must be have a proper distribution system in distributing products. On this basis, an efficient of distribution process analysis in minimizing the cost of distribution of goods with the right delivery time. Analytical Hierarchy Process (AHP) is used to determine the distribution area based on criteria determined in an effort to maximize warehouse capacity. Procurement of information technology tools can minimize distribution costs by 27.79%. Thus, the cost of distributing information technology devices is more efficient.

Kata kunci: System integrator, information technology, Analytical Hierarchy Process (AHP)
educación religiosa escolar en el siglo XXI: una respuesta formativa ante los nuevos escenarios
Authors: Juárez Ramírez Balbino E 
Published: November 2020

El contexto social, cultural, educativo, religioso y eclesial vivido en estos primeros veinte años del nuevo siglo permite vislumbrar nuevos acentos que la educación religiosa escolar debe asumir para ser un proceso formativo significativo y pertinente en América Latina y el Caribe. De la mera transmisión de contenidos doctrinales y morales de una determinada confesión religiosa, debe pasar a promover la sana convivencia y el compromiso social, la valoración de la persona, el crecimiento holístico, el diálogo interreligioso y la asunción de nuevos lenguajes que permitan a la persona entrar en contacto con lo trascendente.