bluuebunny/crossref_metadata_2025_split huggingface dataset:
College Athletes Under Pressure: Eating Disorders Among Female Track and Field Athletes
Authors: Quinn Michael A. , Robinson Stephanie 
Published: July 2020

Eating disorders are a widespread problem for college female athletes. This article builds on this research by collecting survey data from female college track and field athletes at 30 universities. Results find that the division level is not a significant driver of eating disorders. Another significant finding comes from breaking out the pressures into its team-related and social causes. Results find that team-related pressures lead to more vomiting behavior, while social pressures impact dieting. Previous studies which aggregate pressures, rely on one eating disorder, or focus on a single university for their sampling may not reflect these complex relationships. Even after controlling for individual factors, competition level, and team nutritionists, the pressures still impact these athletes. This suggests a need for additional screenings and counselors to address pressures occurring both on and off the track. While difficult to achieve, there needs to be a change in team cultures across all divisions. JEL Classifications: I1, Z2
Reconstructing family doctors’ psychological well-being and motivation for effective performance in China: the intervening role of psychological capital
Authors: Xu Xinglong , Zhou Lulin , Asante-Antwi Henry , Boafo-Arthur Ama , Mustafa Tehzeeb 
Published: July 2020

AbstractBackgroundFamily practice and family doctors are critical part of China’s primary healthcare delivery in a constantly evolving society. As the first point of contact with the medical system, family practices require physically and psychologically sound and a well-motivated family doctors at all times. This is because an error can lead to loss of lives as gatekeepers of the medical system. Our study explored the extent to which positive psychological capital promotes higher performance among family doctors.MethodsA questionnaire was used to collect data from family doctors in Shanghai, Nanjing, and Beijing. We applied a structural equation analysis to analyze the causal relationship among the variables.ResultsWe found out that psychological well-being and job involvement significantly influences the performance of family doctors in China. The study also noted that psychological capital moderates the relationship between psychological well-being attainment, job involvement, and performance.ConclusionsStudies have shown that these pressures affect their well-being considerably. For this reason, a healthcare professional who experiences positive emotions affects the total behavior which culminates into performance.
Potential pharmacological approaches for the treatment of HIV-1 associated neurocognitive disorders
Authors: Omeragic Amila , Kayode Olanre , Hoque Md Tozammel , Bendayan Reina 
Published: July 2020

AbstractHIV associated neurocognitive disorders (HAND) are the spectrum of cognitive impairments present in patients infected with human immunodeficiency virus type 1 (HIV-1). The number of patients affected with HAND ranges from 30 to 50% of HIV infected individuals and although the development of combinational antiretroviral therapy (cART) has improved longevity, HAND continues to pose a significant clinical problem as the current standard of care does not alleviate or prevent HAND symptoms. At present, the pathological mechanisms contributing to HAND remain unclear, but evidence suggests that it stems from neuronal injury due to chronic release of neurotoxins, chemokines, viral proteins, and proinflammatory cytokines secreted by HIV-1 activated microglia, macrophages and astrocytes in the central nervous system (CNS). Furthermore, the blood–brain barrier (BBB) not only serves as a route for HIV-1 entry into the brain but also prevents cART therapy from reaching HIV-1 brain reservoirs, and therefore could play an important role in HAND. The goal of this review is to discuss the current data on the epidemiology, pathology and research models of HAND as well as address the potential pharmacological treatment approaches that are being investigated.
Transmissibility of COVID-19 in 11 major cities in China and its association with temperature and humidity in Beijing, Shanghai, Guangzhou, and Chengdu
Authors: Guo Xiao-Jing , Zhang Hui , Zeng Yi-Ping 
Published: July 2020

Abstract
Background
The new coronavirus disease COVID-19 began in December 2019 and has spread rapidly by human-to-human transmission. This study evaluated the transmissibility of the infectious disease and analyzed its association with temperature and humidity to study the propagation pattern of COVID-19.

Methods
In this study, we revised the reported data in Wuhan based on several assumptions to estimate the actual number of confirmed cases considering that perhaps not all cases could be detected and reported in the complex situation there. Then we used the equation derived from the Susceptible-Exposed-Infectious-Recovered (SEIR) model to calculate R0 from January 24, 2020 to February 13, 2020 in 11 major cities in China for comparison. With the calculation results, we conducted correlation analysis and regression analysis between R0 and temperature and humidity for four major cities in China to see the association between the transmissibility of COVID-19 and the weather variables.

Results
It was estimated that the cumulative number of confirmed cases had exceeded 45 000 by February 13, 2020 in Wuhan. The average R0 in Wuhan was 2.7, significantly higher than those in other cities ranging from 1.8 to 2.4. The inflection points in the cities outside Hubei Province were between January 30, 2020 and February 3, 2020, while there had not been an obvious downward trend of R0 in Wuhan. R0 negatively correlated with both temperature and humidity, which was significant at the 0.01 level.

Conclusions
The transmissibility of COVID-19 was strong and importance should be attached to the intervention of its transmission especially in Wuhan. According to the correlation between R0 and weather, the spread of disease will be suppressed as the weather warms.
Reducing overdose after release from incarceration (ROAR): study protocol for an intervention to reduce risk of fatal and non-fatal opioid overdose among women after release from prison
Authors: Waddell Elizabeth Needham , Baker Robin , Hartung Daniel M. , Hildebran Christi J. , Nguyen Thuan , Collins Deza’Rae M. , Larsen Jessica E. , Stack Erin ,   the ROAR Protocol Development Team, Bialas Tina , Bielavitz Sarann , Gregg Jessica , Korthuis P. Todd , Kunkel Lynn , Lee Joshua D. , Leichtling Gillian , Meyer Dawnell L. , Nichols Ceilidh , Wiest Katharina 
Published: July 2020

Abstract
Background
Drug overdose is the leading cause of death after release from prison, and this risk is significantly higher among women compared to men. Within the first 2 weeks after release, the risk of death from drug overdose is 12.7 times higher than the general population, with risk of death further elevated among females. Although female inmates have higher rates of opioid use disorder and post-release overdose fatality, justice-involved women are under-represented in studies of medications for opioid use disorder. The Reducing Overdose After Release from Incarceration (ROAR) pilot intervention and evaluation (recruitment June 2019 through December 2020) aims to reduce opioid overdose among women released to the community following incarceration in state prison. The evaluation further assesses induction, acceptance and effectiveness of extended release naltrexone in a female post-prison population.

Methods/design
In the week prior to their release, female adults in custody with moderate to severe opioid use disorder start treatment with extended release naltrexone, an injectable opioid antagonist that blocks the effects of opioids for up to 1 month. All ROAR participants receive training to use naloxone rescue kits and are provided nasal naloxone at release. Ongoing support from a certified recovery mentor to facilitate sustained engagement with treatment for substance use disorders begins in the month prior to release from prison and continues for 6 months in community. We evaluate the association between ROAR participation and the primary outcome of opioid overdose.
Using administrative data provided by the Oregon Department of Corrections and the Oregon Health Authority, we compare the odds of overdose among ROAR participants versus a comparison group of females released from prison during the study period. Evaluation activities in community includes survey and qualitative interviews for 6 months post release, as well as a review of clinic records to assess retention on medication among the pilot cohort (N = 100).

Discussion
ROAR is a collaboration between Oregon’s public health, criminal justice, and medical communities. The ROAR intervention and evaluation provide critical information on improving interventions to prevent opioid overdose and improve retention on treatment in community in an overlooked, high-risk population: incarcerated women re-entering the community.

Trial registration
Clinical Trials.gov TRN: NCT03902821.
Molecular identification of CNS NB-FOXR2, CNS EFT-CIC, CNS HGNET-MN1 and CNS HGNET-BCOR pediatric brain tumors using tumor-specific signature genes
Authors: Łastowska Maria , Trubicka Joanna , Sobocińska Anna , Wojtas Bartosz , Niemira Magdalena , Szałkowska Anna , Krętowski Adam , Karkucińska-Więckowska Agnieszka , Kaleta Magdalena , Ejmont Maria , Perek-Polnik Marta , Dembowska-Bagińska Bożenna , Grajkowska Wiesława , Matyja Ewa 
Published: July 2020

AbstractFour molecular types of rare central nervous system (CNS) tumors have been recently identified by gene methylation profiling: CNS Neuroblastoma with FOXR2 activation (CNS NB-FOXR2), CNS Ewing Sarcoma Family Tumor with CIC alteration (CNS EFT-CIC), CNS high grade neuroepithelial tumor with MN1 alteration (CNS HGNET-MN1) and CNS high grade neuroepithelial tumor with BCOR alteration (CNS HGNET-BCOR). Although they are not represented in 2016 updated WHO classification of CNS tumors, their diagnostic recognition is important because of clinical consequences. We have introduced a diagnostic method based on transcription profiling of tumor specific signature genes from formalin-fixed, paraffin-embedded tumor blocks using NanoString nCounter Technology. Altogether, 14 out of 187 (7.4%) high grade pediatric brain tumors were diagnosed with either of four new CNS categories. Histopathological examination of the tumors confirmed, that they demonstrate a spectrum of morphology mimicking other CNS high grade tumors. However, they also exhibit some suggestive histopathological and immunohistochemical features that allow for a presumptive diagnosis prior to molecular assessment. Clinical characteristics of patients corroborated with the previous findings for CNS EFT-CIC, CNS NB-FOXR2 and CNS HGNET-MN1 patients, with a favorable survival rate for the latter two groups. Among six CNS HGNET-BCOR patients, three patients are long term survivors, suggesting possible heterogeneity within this molecular category of tumors. In summary, we confirmed the effectiveness of NanoString method using a single, multi-gene tumor specific signature and recommend this novel approach for identification of either one of the four newly described CNS tumor entities.
D-dimer as a biomarker for disease severity and mortality in COVID-19 patients: a case control study
Authors: Yao Yumeng , Cao Jiatian , Wang Qingqing , Shi Qingfeng , Liu Kai , Luo Zhe , Chen Xiang , Chen Sisi , Yu Kaihuan , Huang Zheyong , Hu Bijie 
Published: July 2020

Abstract
Background
Over 5,488,000 cases of coronavirus disease-19 (COVID-19) have been reported since December 2019. We aim to explore risk factors associated with mortality in COVID-19 patients and assess the use of D-dimer as a biomarker for disease severity and clinical outcome.

Methods
We retrospectively analyzed the clinical, laboratory, and radiological characteristics of 248 consecutive cases of COVID-19 in Renmin Hospital of Wuhan University, Wuhan, China from January 28 to March 08, 2020. Univariable and multivariable logistic regression methods were used to explore risk factors associated with in-hospital mortality. Correlations of D-dimer upon admission with disease severity and in-hospital mortality were analyzed. Receiver operating characteristic curve was used to determine the optimal cutoff level for D-dimer that discriminated those survivors versus non-survivors during hospitalization.

Results
Multivariable regression that showed D-dimer > 2.0 mg/L at admission was the only variable associated with increased odds of mortality [OR 10.17 (95% CI 1.10–94.38), P = 0.041]. D-dimer elevation (≥ 0.50 mg/L) was seen in 74.6% (185/248) of the patients. Pulmonary embolism and deep vein thrombosis were ruled out in patients with high probability of thrombosis. D-dimer levels significantly increased with increasing severity of COVID-19 as determined by clinical staging (Kendall’s tau-b = 0.374, P = 0.000) and chest CT staging (Kendall’s tau-b = 0.378, P = 0.000). In-hospital mortality rate was 6.9%. Median D-dimer level in non-survivors (n = 17) was significantly higher than in survivors (n = 231) [6.21 (3.79–16.01) mg/L versus 1.02 (0.47–2.66) mg/L, P = 0.000]. D-dimer level of > 2.14 mg/L predicted in-hospital mortality with a sensitivity of 88.2% and specificity of 71.3% (AUC 0.85; 95% CI = 0.77–0.92).

Conclusions
D-dimer is commonly elevated in patients with COVID-19. D-dimer levels correlate with disease severity and are a reliable prognostic marker for in-hospital mortality in patients admitted for COVID-19.
Plasma frequency demand for mode conversion processes from slow Z-mode to LO-mode waves in an inhomogeneous plasma
Authors: Kalaee Mohammad Javad , Katoh Yuto 
Published: July 2020

AbstractThe mode conversion process responsible for radio wave generation has been studied for several decades; however, the properties of the condition required for an efficient conversion process are still unknown. The aim of this study is to determine the value of plasma frequency required for an efficient mode conversion process from slow Z-mode to left-hand ordinary (LO)-mode waves in the matching cases, where the two branches of the dispersion relation of the two modes are perfectly connected. We derive the dispersion relations for electromagnetic wave propagation in an inhomogeneous plasma considering Snell’s law and investigated them in detail. We quantify the minimum variation of plasma frequency required for the efficient mode conversion process, which we call “the plasma frequency demand.” We show that the condition required for the efficient mode conversion can be satisfied by waves propagating first toward the high-density region and then returning toward the low-density region before reaching the region where the wave frequency matches the cutoff frequency; therefore, a large inhomogeneity is not always required. We show that the angle between the background magnetic field and the density gradient has a significant effect on the plasma frequency demand.
Heavy shoulder strengthening exercise in people with hypermobility spectrum disorder (HSD) and long-lasting shoulder symptoms: a feasibility study
Authors: Liaghat Behnam , Skou Søren T. , Jørgensen Uffe , Sondergaard Jens , Søgaard Karen , Juul-Kristensen Birgit 
Published: July 2020

AbstractBackgroundPeople with hypermobility spectrum disorder (HSD) are in great risk of experiencing shoulder symptoms, but evidence for treatment is sparse. Therefore, the objective was to evaluate the feasibility of 16-week shoulder strengthening programme for improving shoulder strength and function in people with HSD and shoulder symptoms for more than 3 months to inform a future randomised controlled trial (RCT).MethodsTwelve participants (11 females, 39.3 ± 13.9 years) with HSD and shoulder instability and/or pain for more than 3 months underwent a 16-week heavy shoulder strengthening exercise programme three times weekly using exercises targeting scapular and rotator cuff muscles. Primary outcomes were pre-defined research progression criteria including recruitment rate (acceptable, 6 participants/month), assessment duration (acceptable: < 120 min), participant retention (acceptable: > 80% complete intervention), training adherence (acceptable: > 75% adhere to > 36 training sessions) and adverse events (acceptable: minor events with no participants discontinuing the study), besides participant and physiotherapist feedback. Secondary treatment outcomes were assessed using the Western Ontario Shoulder Instability Index (WOSI, 0–2100 better to worse), self-reported pain, kinesiophobia and fatigue, isometric shoulder strength, besides clinical tests for instability, hypermobility, laxity, and proprioception.ResultsRecruitment rate was 5.6/month, assessment duration (mean ± SD) 105 ± 9 min, retention 100%, adherence 83%, and four participants experienced short-lasting soreness or pain. Participant feedback was positive, and physiotherapists found the intervention relevant and applicable to the population. The WOSI total score showed an improvement by 51% (mean ± SD, points: baseline 1037 ± 215; Follow up 509 ± 365; mean change (95% CI), − 528 (− 738, − 318)), and participants reported reduced pain, kinesiophobia and fatigue. Shoulder strength measurements improved by 28–31% (mean change (95% CI), Nm/kg: scaption 0.51 (0.23, 0.78); internal rotation 1.32 (0.70, 1.95) and external rotation 0.89 (0.37, 1.40)), and clinical tests indicated decreased shoulder laxity/instability.ConclusionsThe shoulder strengthening exercise programme was feasible and safe for people with HSD and long-lasting shoulder symptoms. A future RCT, with an improved recruitment strategy, will demonstrate whether the exercise programme is also effective in improving symptoms and muscle-tendon function in this population.Trial registrationClinicalTrials.gov:NCT03547570. Registered on May 3, 2018.
Identification of epiretinal proliferation in various retinal diseases and vitreoretinal interface disorders
Authors: Chehaibou Ismael , Pettenkofer Moritz , Govetto Andrea , Rabina Gilad , Sadda SriniVas R. , Hubschman Jean-Pierre 
Published: July 2020

Abstract
Background
To describe the presence of epiretinal proliferation in eyes with various retinal and vitreoretinal interface conditions.

Methods
Consecutive patients seen at the Stein Eye Institute, by one retina specialist, from December 2018 to March 2019, and demonstrating epiretinal proliferation on optical coherence tomography (OCT) were enrolled in this cross-sectional study. Included patients were divided into two groups: vitreoretinal interface pathologies group or retinal diseases group. Presence of epiretinal proliferation and its localization within the 9 macular sectors, as defined by the Early Treatment Diabetic Retinopathy Study (ETDRS), were assessed on OCT.

Results
77 eyes from 69 patients demonstrated epiretinal proliferation on OCT. The most frequently involved ETDRS sector was the 1-mm central subfield, followed by inner temporal and inner nasal sectors. Localization of epiretinal proliferation correlated with the presence of any retinal abnormalities in the same quadrant (r = 0.962; P < 0.0001). 31 eyes (40.3%) demonstrated symptomatic vitreoretinal interface pathologies including lamellar macular hole, full-thickness macular hole, epiretinal membrane and history of macular peeling. 46 eyes (59.7%) manifested various retinal diseases, including age-related macular degeneration, diabetic retinopathy, refractory macular edema, vein occlusion and high myopia.

Conclusions
Epiretinal proliferation was noted in several retinal conditions and not limited only to full-thickness and lamellar macular holes. Different mechanisms affecting retinal homeostasis might trigger Müller cells dysregulation, potentially leading to abnormal retinal remodeling.
Patterns of olfactory dysfunctions in patients with Parkinson disease
Authors: Rashed Khaled Hussein , Bahnasy Wafik Said , El-Heneedy Yasser Abo Elfotoh , El-Seidy Ehab Ahmed Shawky , Tomoum Mohamed Osama , Eltomey Mohamed Adel , ELAhwal Shereen Ahmed 
Published: July 2020

Abstract
Background
Olfactory dysfunction (OD) is a well-established nonmotor manifestations (NMM) of Parkinson disease (PD) which needs objective assessment for better understanding of the disease pathogenesis. The aim of this work was quantitative and qualitative assessment of olfactory performance in newly diagnosed PD patients.

Methods
This study was performed on 32 recently diagnosed PD patients and 24 healthy controls subjects (HCS) submitted to unified Parkinson’s disease rating scale–III (UPDRS–III), extended n-butanol Sniffin’ Sticks test (SST) and olfactory bulbs volumetry (OBV).

Results
There were significant decreases in SST threshold, discrimination, identification, and TDI variables as well as OBV in PD patients compared to HCS. The olfactory performance was negatively correlated with disease duration but had no relation with PD severity as well as motor subtype.

Conclusion
OD is highly prevalent during the early stages of PD which is both measurable and specific with identification and discrimination impairments to certain odors which makes smell performance testing an important step in PD patients’ evaluation.
Effect of main frequencies on characterizing fault damage zones using forward modeling and attribute of variance
Authors: Chen Yangpu , Liao Zonghu , Fu Li-Yun , Zhou Gang , Xu Liang , Marfurt Kurt J. , Mu Xinru , Zou Huayao 
Published: July 2020

Faulting processes have created large damage zones with complex structures in the field; however, estimating the width and geometry of such fault structures in the subsurface is challenging due to a lack of data. Seismic attributes (e.g., coherence and variance) from seismic surveys have been used for the characterization of faults, but most cases do not detail the effectiveness of this approach. By using forward modeling and the associated seismic attributes of variance, four fault models of idealized damage zones are characterized and the frequency effect is evaluated on the width estimation of fault damage zones in the subsurface. The main results indicate that (1) the general geometric pattern of damage zones could be identified by using simulated amplitude and seismic variance with main frequencies of 10, 25, and 40 Hz; (2) the estimated widths of damage zones at a low frequency of 10 Hz are larger (up to twofold) than those at frequencies of 25 and 40 Hz; for large damage zones (>400 m), the width is best estimated by a frequency of 25 Hz; and (3) scattering noise and diffraction around the fault are found in data at a high frequency of 40 Hz, which results in width overestimation of the damage zones by approximately 17%. The internal structures are difficult to distinguish as scattering noise and chaotic reflections dominate seismic signals. More factors that may influence the accuracy of damage zone width estimation via seismic attributes, include the bedding thickness, fracture density, and velocity. An in-depth understanding of this approach is useful in the application of seismic variance to characterize fault damage zones that may significantly control the fluid migration in the subsurface.