bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparative study on the jade drilling technology of ancient Mesoamerican civilizations and prehistoric China
Authors: Wen Yadi 
Published: December 2024

Abstract
Through the examination of Olmec jade objects at the Dumbarton Oaks Museum and Maya jade artifacts from the Chichén Itzá site housed in the Peabody Museum of Archaeology and Ethnology, two categories of drilling techniques have been identified: practical and ritual. Practical drilling encompasses drilling positioning, sequential drilling for decoration and openwork. Ritual drilling imbues jade objects with symbolism related to breath and life. In Neolithic China, two systems of drilling techniques for jade processing have been reconstructed: axial rotary drilling and bearing rotary drilling.
Exploring the safety and diagnostic utility of amniocentesis after 24 weeks of gestation: a retrospective analysis
Authors: Gupta Tanisha , Dadhwal Vatsla , Rana Anubhuti , Kabra Madhulika , Gupta Neerja , Shukla Rashmi , Sharma K. Aparna 
Published: December 2024

Abstract

Objectives
This study aims to describe the indications, complications, yield, and safety of amniocentesis beyond 24 weeks for prenatal diagnostic procedures along with the associated maternal and fetal outcomes.

Methods
A retrospective analysis was conducted on 60 pregnant women (with 61 fetuses) who underwent amniocentesis at or beyond 24 weeks from March 2021 to June 2023 at a tertiary care referral center. Data was collected from medical records and individual patient followups. Descriptive data was collected on patient demographics, amniocentesis indications, and the test results. The other outcomes analyzed were the procedure-related complications and pregnancy outcomes.

Results
The mean gestational age at time of the procedure was 254/7 (241/7–331/7). The most common indication for late amniocentesis was abnormal sonographic findings (44/61, 72.13 %), with structural anomalies being the commonest (21/61, 34.44 %). There were no complications related to the procedure. Of the 60 women, 88.3 % (53/60) continued their pregnancies, while 11.66 % (7/60) opted for termination of pregnancy, and two patients had intrauterine fetal demise (2/61, 3.27 %). Genetic testing revealed abnormalities in 6.55 % (4/61) of cases. Of the 51 pregnancies, 39 delivered vaginally (76.47 %; 39/51) and 12 (23.52 %; 12/51) required caesarean sections. There were five neonatal and infant deaths due to heart defects (2), metabolic syndrome, congenital diaphragmatic hernia, and non-immune hydrops, respectively.

Conclusions
Amniocentesis, done at a later gestation, is a safe and an effective tool for prenatal diagnosis and provides an opportunity to make a genetic diagnosis and further counseling.
Auteurism in Tár
Authors: Hubbert Julie 
Published: December 2024

When the film Tár premiered in the fall of 2022, it immediately generated both praise and controversy. Critics and viewers were impressed by actress Cate Blanchett’s tour-de-force portrayal of the fictious orchestral conductor Lydia Tár. Just as many, however, found the film’s depiction of the classical music world as a profession rife with sexual misconduct and predatory behavior disturbing. The film’s critique of both the #MeToo movement and the failures and excesses of contemporary cancel culture as well as its inaccurate depiction of gender parity on the podium also generated heated and angry responses. Real women conductors including Marin Alsop spoke out against the film on multiple grounds. “I was offended as a woman, as a lesbian and as a conductor,” Alsop declared.
While the film addresses the use and abuse of wealth, privilege, and power in the classical music world, its music and soundtrack choices also point to a uniquely cinematic critique of the long-standing and problematic concept of the film auteur. In Tár, the director Todd Field wielded unprecedented control over the music, selecting and shaping what musical works Tár performs and discusses in the film and what music and dialogue the audiences hear on the film’s official soundtrack. Field used the music of Gustav Mahler in particularly striking ways, to convey the title character’s abilities and ambitions but also to generate intertextual meaning, to establish an unusual hyper-allusive and hyper-self-conscious discursive register. Field appropriates Mahler’s Fifth Symphony not just visually and musically but cinematically to scrutinize the boundaries of the art film and redefine the musical parameters of the contemporary auteur.
ТРАНСФОРМАЦИЯ МИГРАЦИОННЫХ ПРОЦЕССОВ В КРЫМУ В СОВРЕМЕННЫХ УСЛОВИЯХ
Authors: Чернышев Константин Анатольевич 
Published: December 2024

Целью исследования является изучение миграционной динамики населения Крыма за период с 2019 по 2023 годы.
Методология. Теоретической основой работы являются исследования региональной миграции в России. Центральное место в работе занимает анализ помесячных данных текущего статистического учета о количестве прибывающих и выбывающих в Севастополь и Республику Крым долговременных мигрантов.
Результаты. В статье описывается динамика миграционных процессов на Крымском полуострове в 2019–2023 годах. Информационной базой явились данные текущего учёта долговременной миграции в городе федерального значения Севастополь и Республике Крым. На основе помесячной динамики числа прибывших и выбывших проанализировано изменение потоков миграционного прироста в периоды распространения пандемии COVID-19 и проведения специальной военной операции.
Выводы. В течение рассматриваемого периода произошёл переход к отрицательному миграционному балансу на полуострове в целом. При этом в Республике Крым отрицательное сальдо миграции более выражено и проявилось раньше по времени, чем в Севастополе. В дальнейшем по мере снижения рисков, связанных с действиями Украины, регионы Крыма будут испытывать конкуренцию со стороны новых субъектов РФ, которые начнут привлекать часть мигрантов, желающих переехать в благоприятные в природно-климатическом отношении южные регионы нашей страны.
Перспективы исследования связаны с дальнейшим изучением миграционных процессов в Крыму и новых регионах России, условием которого является совершенствование информационной базы и качества миграционной статистики.
ПОДХОДЫ К ФОРМИРОВАНИЮ ОТНОШЕНИЯ К СЕМЬЕ И ТРАДИЦИОННЫМ СЕМЕЙНЫМ ЦЕННОСТЯМ В ПРОЦЕССЕ ПРОФЕССИОНАЛЬНОЙ АДАПТАЦИИ И КОЛЛЕКТИВНОГО ТРУДОВОГО ВОСПИТАНИЯ СТУДЕНТОВ
Authors: Самойленко Дмитрий Николаевич 
Published: December 2024

Целью исследования является анализ влияния трудового воспитания на формирование отношения к традиционным российским духовно-нравственным и прежде всего к семейным ценностям у студентов.
Методология исследования. Методологически проведен сравнительно-исторический анализ работ основателей отечественной педагогики, а также результатов современных исследователей.
Результаты исследования. Раскрываются проблемы формирования традиционных семейных ценностей у студенческой молодежи. Приводятся негативные современные тенденции искажения традиционных семейных ценностей в этой среде. Высказывается гипотеза об эффективности трудового воспитания в процессе начальной социально-профессиональной адаптации студентов как важного элемента приобщения к традиционным духовно-нравственным, в том числе семейным, ценностям. Предложено практическое образовательно-воспитательное решение в виде выездного начального социально-профессионального адаптационного курса. Обоснована актуальность формирования отношения к семье в процессе профессиональной адаптации и коллективного трудового воспитания студентов с учетом традиционных российских духовно-нравственных ценностей. Приводятся результаты успешной практической реализации пилотного курса для студентов-младшекурсников. Уделено внимание обоснованию организации и изложению опыта реализации внеучебной воспитательной трудовой деятельности студентов с целью формирования дружных трудовых студенческих коллективов, воспринимающих и разделяющих традиционные семейные ценности.
Перспективы исследования. Предложенный курс рекомендуется российским вузам как эффективный инструмент формирования отношения студенческой молодежи к семье и традиционным российским семейным ценностям в процессе социально-профессиональной адаптации и коллективного трудового воспитания.
An assessment of burden of active hepatitis C virus infection in HCV seropositive individuals in Gujarat- A retrospective study
Authors: Maheta Hemanshi , Sood Nidhi , Mandalia Asha , Rao Palak , Baldaniya Neha 
Published: December 2024

: Viral hepatitis is a major public health challenge that requires an urgent response as the disease is a 2nd leading infectious cause of death globally causing 1.3 million deaths per year. Hepatitis B and C, the two main types of the five hepatitis infections are responsible for 96% of viral hepatitis related mortality. HCV is commonly associated with chronicity, cirrhosis and hepato-cellular carcinoma. Screening for HCV is done with antibody detection. Sero-positivity is not an evidence of an active HCV infection, for which viral RNA detection is necessary. As appropriate standard testing by RTPCR for active infection is not done, patients do not receive proper treatment and data pertaining to true burden of disease in community remains hidden. To determine prevalence of active hepatitis C virus infection in HCV antibody positive individuals.: Retrospective study was conducted at Microbiology Department, GMERS Medical College and hospital, Ahmedabad, from January 2020 to March 2024. A total of 763 sero-positive samples were received and tested for active HCV infection from 18 districts of Gujarat with RTPCR assay to ascertain active infection. Of 763 samples tested, 47.31% samples were positive and 48.23% samples were negative for HCV RNA. In active infection cases, 63.99% were male and 38.78% were female. Most common age group affected was 40-60 yrs. Highest prevalence was seen in South Gujarat. Regional variations in active disease burden was demonstrated.: Sero- positivity of HCV does not inform about active infection of HCV. Active infection is very high in sero-positive individuals. To reduce chronicity and associated mortality and morbidity of HCV infection, RNA detection, a gold standard diagnostic tool should be adopted for ascertaining the active infection status. With the availability of very effective directly acting antivirals for HCV, morbidity and mortality associated with HCV can be reduced.
Effects of Tartaric Acid on Eosinophil Activation and Th2 Cytokines in Mice
Authors: Riaz Bushra , Ryu Hye-Myung , Choi Bunsoon , Sohn Seonghyang 
Published: December 2024

Eosinophils are granulocytes involved in the effector phase of type 2 T cell immune responses, which are elevated in inflammatory conditions like ulcerative colitis (UC) and other allergic diseases. UC is a chronic inflammatory colon disease, marked by excessive eosinophil infiltration, upregulation of their regulatory molecules, and elevated Th2 cytokines, which contribute to mucosal inflammation and tissue damage. This research is the first to explore the dose-dependent effects of tartaric acid (TA), a naturally occurring organic acid, on eosinophil activation and Th2 cytokine response in both normal mice and a dextran sulfate sodium (DSS)-induced colitis model. Normal mice were treated with TA at varying doses (5 µg, 25 µg, and 50 µg/mouse/day), while colitis mice received 50 µg TA. Eosinophil activation markers (CD11b+, SiglecF+, CCR3+) and Th2 cytokines (IL-4, IL-13, IL-31), and IL-17 were assessed in peripheral blood leukocytes, lymph nodes, and splenocytes using flow cytometry. Additionally, mRNA expression levels of eosinophil-associated chemokines and cytokines in the splenocytes were quantified with real-time qPCR. Our results demonstrate a dose-dependent effect of TA, with the highest dose (50 µg) significantly increasing eosinophil activation markers, Th2 cytokines, IL-17, and mRNA expression of SiglecF, CCL11 and toll-like receptor 4 in normal mice. In colitis mice, treatment with 50 µg TA showed marked increases in IL-13 levels compared to untreated colitis mice, reflecting increased eosinophil recruitment to inflamed tissues. Moreover, mRNA expression of IL-5Rα was elevated in normal mice and colitis mice administered with TA. These results suggest that TA enhances eosinophil proliferation, upregulation of their regulatory molecules, and Th2 immune profiles, potentially worsening the severity of colitis.
Traumatic Anterior Hip Dislocation With an Open Book Pelvic Fracture and Femoral Artery Compression
Authors: Gomez-Sierra María Antonia , Martinez-Rondanelli Alfredo , Palacio Laura , Martinez-Cano Juan Pablo 
Published: December 2024

Case:
A 34-year-old patient was involved in a motorcycle accident, resulting in an anterior hip dislocation associated with an open book pelvic fracture and compression to the femoral artery. He required an emergent closed reduction of the hip dislocation and open reduction and internal fixation of the pelvic fracture.

Conclusion:
This case underscores the importance of maintaining a high level of suspicion for anterior hip dislocation, particularly in patients involved in motorcycle accidents, where a flexed, abducted, and externally rotated hip is common. Timely diagnosis allows for prompt treatment, leading to better functional prognosis and improved survival opportunities.
Automated Balanced Cable Trifocal Bone Transport
Authors: Haruno Lee S. , Owen Jonas K. , Marecek Geoffrey S. 
Published: December 2024

Case:
A 14-year-old adolescent boy sustained a Gustilo-Anderson Type 3A tibia fracture treated with medullary nailing. He developed an atrophic nonunion with a 10.5-cm defect after debridement. An automated hexapod system was adapted to perform trifocal tandem cable transport. Transport proceeded at 0.75 mm/day per focus, segmented into 16 increments. Docking and conversion to a nail occurred 103 days after frame application for an external fixation index of 9.8 days/cm.

Conclusion:
Automated balanced cable transport is a viable option for segmental bone defects. This is the first reported automated balanced cable transport.
Rare Presentation of Chondroblastoma of the Patella, a Case Report
Authors: Fang William H. , Fan Juston , Nael Ali , Misaghi Amirhossein 
Published: December 2024

Case:
Chondroblastoma, a rare benign bone tumor, often occurs in skeletally immature individuals, with patellar involvement in <2% of cases. We report a 14-year-old adolescent boy with anterior knee pain and a patellar chondroblastoma. Imaging revealed a radiolucent lesion, and biopsy confirmed the diagnosis. Curettage and grafting led to pain resolution, full range of motion, and sports clearance at 6 months with no recurrence.

Conclusion:
Patellar chondroblastomas are exceptionally rare, usually arising in long bone epiphyses. Differential diagnosis includes Langerhans cell histiocytosis, giant cell tumors, and clear cell chondrosarcoma, requiring histological and imaging analysis. Recurrence risk mandates ongoing clinical and radiological monitoring.
WITHDRAWN: On Practical uniform of perturbed triangular system of two differential equations named by integral input stat stable system
Authors: Moter Amany M. , Ellouze Ines 
Published: December 2024

Abstract

The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Statistically Enhanced Learning: a feature engineering framework to boost (any) learning algorithms
Authors: Felice Florian , Ley Christophe , Bordas Stéphane P.A. , Groll Andreas 
Published: December 2024

Abstract

Feature engineering is of critical importance in the field of Data Science. While any data scientist knows the importance of rigorously preparing data to obtain good performing models, only scarce literature formalizes its benefits. In this work, we present the method of Statistically Enhanced Learning (SEL), a formalization framework of existing feature engineering and extraction tasks in Machine Learning (ML). Contrary to existing approaches, predictors are not directly observed but obtained as statistical estimators. Our goal is to study SEL, aiming to establish a formalized framework and illustrate its improved performance by means of simulations as well as applications on practical use cases.
Is it a bat or a male? A female moth (Syntomeida epilais, Lepidoptera: Erebidae: Arctiinae) adapts its acoustic signals for defense or courtship
Authors: Coro Frank 
Published: December 2024

Abstract

Courtship behavior in the polka-dot wasp moth Syntomieda epilais is the most elaborate acoustic communication system known in the Erebidae. Both males and females must emit their acoustic signals for successful mating under natural conditions in the presence of insectivorous echolocating bats. Females of S. epilais were stimulated during their courtship period (between 02 ÷ 30 and 06 ÷ 30) with playback of conspecific male and female signals and of a sympatric bat attack sequence and their acoustic emissions were recorded. On the third night post-eclosion at the initiation of courtship behavior, females discriminate among these types of acoustic series, responding preferentially to conspecific male signals. In contrast, during the first two nights post-eclosion, they respond strongly to the bat attack sequence but not to conspecific male signals. It is demonstrated that post-mated female moths stop responding to conspecific male signals, while continuing to respond to the bat attack series. These and other novel observations suggest that these female moths can modulate their acoustic signals, according to the stimulating conditions for defense against bats or courtship, by varying their response thresholds and latencies.
Characterization of a non-specific lipid transfer protein from Betula platyphylla and identification of Bp ns LTPs response to drought stress
Authors: shi jingjing , Chen Shizhong , Gao yan , Gao caiqiu , Wang Chao 
Published: December 2024

Abstract

The non-specific lipid transfer protein (nsLTP) is a plant gene family that significantly influences plant growth, development, and adaptation to environmental stresses, particularly in response to biotic and abiotic stresses. This study characterized the nsLTP family and identified 23 nsLTP genes in birch (Betula platyphylla). Based on the sequence similarity and the presence of eight cysteine amino acid residues, BpnsLTP proteins were clustered into five types: type I, III, IV, V and VI. Seven nsLTPs were screened using by drought stress transcriptome analysis and qRT-PCR results proved that three nsLTP genes were positively responded to drought stress and four nsLTP genes were negatively responded to drought stress. Co-expression and go enrichment analysis revealed that genes co expressed with LTP genes were enriched in which futher domastrated these LTP were invleved plant abiotic stress. Subcellular localization experiment showed that BpnsLTPI.3 proteins were localized on cell membrane. Obtaining BpnsLTPI.3 overexpressing birch transgenic lines through leaf disk method, after treating transgenic and wild-type lines with 10% PEG6000 stress, various physiological and biochemical parameters were assessed. It was observed that the drought tolerance of the transgenic lines was significantly lower compared to the wild-type lines. Specifically, NBT and Evans blue staining indicated more pronounced stress-induced damage in the transgenic lines than in the wild-type. Moreover, the transgenic lines exhibited lower levels of protective enzymes such as POD and SOD, while the content of MDA and H2O2 was higher in comparison to the wild-type lines. These results suggest that BpnsLTPI.3, under the PEG6000 stress treatment, modulates protective enzyme activities, scavenges reactive oxygen species, and maintains cellular integrity in a manner that ultimately diminishes the drought tolerance of the transgenic birch plants. These results provide new insights into the biological functions of the nsLTP family of B. platyphylla in response to abiotic stress.
Human immunocompetent microfluidic platform for in vitro testing in immuno-oncology applications
Authors: Modena Mario , Lohasz Christian , Häfeli Tamara , Hasanova Dzhansu , Hölting Lisa , Rudnik Michal , Lützow Svenja , Mehta Avni , Kritzer Bettina , Laternser Sandra , Nazarian Javad , Frey Olivier , Hierlemann Andreas 
Published: December 2024

Abstract

In vitro evaluation of novel therapeutic approaches often fails to reliably predict efficacy and toxicity, especially when recapitulating conditions involving recirculating cells. Current testing strategies are often based on static co-culturing of cells in suspension and 3D tissue models, where cell sedimentation on the target tissue can occur. The observed effects may then mostly be a consequence of sedimentation and of the corresponding forced cell-tissue interactions. The realization of continuous medium flow helps to better recapitulate physiological conditions. To tackle current limitations of perfused organ-on-chip approaches, we developed a microfluidic chip and operation concept, which prevents undesired sedimentation and accumulation of cells in suspensions over multiple days by relying on gravity-driven perfusion. Our platform, which we termed “human immune flow (hiFlow) chip”, enables to co-culture cells in suspension with up to 7 preformed microtissue models. The primary goal was to study flow-dependent recruitment of the circulating cells to the different tissue spheroids. Cells and tissues could be monitored on-chip via high-resolution microscopy, while cell suspensions and microtissues could be easily retrieved for off-chip analysis. Our results demonstrate that primary immune cells and spheroid models of healthy and diseased tissue can be maintained for over 6 days on chip. As proof-of-principle assay, we investigated the efficacy of antibody treatment against diffuse midline glioma, a highly aggressive pediatric tumor. We believe that our platform will help to increase the prediction power of in vitro preclinical testing of novel immunotherapeutics.
Do cyberbullies develop depressive symptoms? A longitudinal multi-study
Authors: Bansal Suhans , Garg Naval , Singh Jagvinder 
Published: December 2024

Abstract

Purpose
Researchers have adequately explored the impact of cyberbullying on the mental health of cyber victims. However, its ill effects on cyberbullies are yet to be examined sufficiently. Moreover, existing studies have not answered why cyberbullying leads to mental health issues among cyberbullies. Therefore, to bridge these gaps, this study examined the relationship between cyberbullying (two factors, HCA and GCC) and depressive symptoms among cyberbullies. Also, the study examined the mediating effects of guilt and fear as a mechanism that explains the development of depressive symptoms among cyberbullies.
Methods
Two studies (college students and working professionals) were conducted through three-wave data collection. The relationships between the two dimensions of cyberbullying and depression were examined using correlation and hierarchical regression analysis. Demographic variables like age and gender were used as control variables. Mediation effects were analysed using the PROCESS macro in SPSS.
Findings:
The correlation and hierarchical regression suggest that HCA and GCC significantly predict depressive symptoms among cyberbullies, and age and gender (control variables) are not significant predictors. The PROCESS macro results indicated a significant mediation effect of fear and guilt, thereby suggesting that they act as mechanisms explaining the development of depressive symptoms in cyberbullies.
Originality:
It is the first of its kind of study that suggests that cyberbullies also develop depressive symptoms out of their act of cyberbullying others. Secondly, it is a pioneer study that suggests guilt and fear can mediate the relationship between cyberbullying perpetration/attitude and depressive symptoms in cyberbullies, especially in the Indian context.