bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methodische Herausforderungen bei der Nutzung von Daten von mehr als
70 gesetzlichen Krankenkassen – Ein Werkstattbericht aus der
EVA64-Studie
Authors: March Stefanie , Zimmermann Linda , Kubat Denise , Neumann Anne , Schmitt Jochen , Baum Fabian , Schoffer Olaf , Arnold Katrin , Seifert Martin , Kliemt Roman , Häckl Dennis , Pfennig Andrea , Swart Enno 
Published: January 2020

Zusammenfassung
Ziel der Studie Die angemessene und bedarfsgerechte Betreuung psychisch
erkrankter Patienten stellt besondere Anforderungen an die psychiatrische
Versorgung. §64b SGB V eröffnet die Möglichkeit,
psychisch Erkrankte durch multiprofessionelle, behandlungsphasen- und
sektorenübergreifende Modellvorhaben zu betreuen und neue
Finanzierungsformen zu implementieren. Diese Modellprojekte werden seit 2015 in
einer prospektiven und retrospektiven sekundärdatenbasierten
kontrollierten Kohortenstudie (EVA64) evaluiert.
Methode Im September 2016, und seitdem jährlich, erfolgte
erstmalig die Datenbereitstellung aller an der Evaluation beteiligten
gesetzlichen Krankenversicherungen (GKV) auf der Basis einer konsentierten
Datensatzbeschreibung. Für die spätere Analyse sind die
eindeutige Identifikation des Indexaufenthaltes und die Zuordnung zu Modell-
oder Kontrollgruppe von Bedeutung. Die methodischen Herausforderungen der
Datenbereitstellung durch die Dateneigner, das Einlesen, die formale und
inhaltliche Prüfung sowie die anschließende
Zusammenführung zu einem Auswertedatensatz werden ausführlich
diskutiert und Fallstricke aufgezeigt.
Ergebnisse Insgesamt wurden bislang Daten von 71 Krankenkassen
berücksichtigt. In jeweils 20 Tabellen pro Kasse wurden Leistungsdaten
zur vertragsärztlichen, ambulanten und stationären Versorgung im
Krankenhaus (inkl. Psychiatrische Insti-tutsambulanzen [PIA]), Arznei- und
Heilmittelversorgung sowie Arbeitsunfähigkeit übermittelt. Nicht
alle Tabellen konnten von den Krankenkassen vollständig gefüllt
werden. Zudem bedingen neue inhaltliche Aspekte u. a. die Anpassung der
Datenselektion. Trotz mehrmaliger Datenlieferungen kann noch nicht von einem
Routinevorgehen gesprochen werden.
Schlussfolgerung Die kassenübergreifende Nutzung von
Abrechnungsdaten zahlreicher GKVen im Rahmen einer Evaluationsstudie stellt eine
große Herausforderung dar. Angesichts fehlender Richtwerte für
Auffälligkeiten und Implausibilitäten war eine a-priori
Festlegung von Prüfalgorithmen nur bedingt möglich; diese
müssen vielmehr im Projektverlauf fortlaufend aktualisiert werden. Die
resultierende individuelle Prüfung der Daten aller Krankenkassen
gestaltet sich dadurch sehr aufwändig. Die ausführliche
Dokumentation dieser Prüfprozesse und möglicher Fallstricke gibt
Hilfestellung für zukünftige vergleichbare Studien.
Quantitative Sensory Changes Following Gasserian Ganglion Radiofrequency Thermocoagulation in Patients with Medical Refractory Trigeminal Neuralgia: A Prospective Consecutive Case Series
Authors: Huckhagel Torge , Bohlmann Lars , Westphal Manfred , Regelsberger Jan , Eichler Iris-Carola , Hamel Wolfgang 
Published: January 2020

Abstract
Background and Objective Microsurgical vascular nerve decompression and percutaneous ablative interventions aiming at the Gasserian ganglion are promising treatment modalities for patients with medical refractory trigeminal neuralgia (TN). Apart from clinical reports on a variable manifestation of facial hypoesthesia, the long-term impact of trigeminal ganglion radiofrequency thermocoagulation (RFT) on sensory characteristics has not yet been determined using quantitative methods.
Material and Methods We performed standardized quantitative sensory testing according to the established protocol of the German Research Network on Neuropathic Pain in a cohort of patients with classical (n = 5) and secondary (n = 11) TN before and after percutaneous Gasserian ganglion RFT (mean follow-up: 6 months). The test battery included thermal detection and thermal pain thresholds as well as mechanical detection and mechanical pain sensitivity measures. Clinical improvement was also assessed by means of renowned pain intensity and impairment questionnaires (Short-Form McGill Pain Questionnaire, Pain Disability Index, and Pain Catastrophizing Scale), pain numeric rating scale, and anti-neuropathic medication reduction at follow-up.
Results All clinical parameters developed favorably following percutaneous thermocoagulation. Only mechanical and vibration detection thresholds of the affected side of the face were located below the reference frame of the norm population before and after the procedure. Statistically significant persistent changes in quantitative sensory variables caused by the intervention could not be detected in our patient sample.
Conclusion Our data suggest that TN patients improving considerably after RFT do not undergo substantial long-term alterations regarding quantitative sensory perception.
Malignant “Angioglioma”: Clinical, Radiologic, and Histopathologic Features
Authors: Linsenmann Thomas , Westermaier Thomas , Monoranu Camelia , Amaya Franco , Keßler Almuth , Ernestus Ralf Ingo , Löhr Mario , Stetter Christian 
Published: January 2020

Abstract
Background Glioblastoma multiforme (GBM) is the most frequent malignant neoplasm in the adult brain. In contrast, arteriovenous malformations (AVMs) are presumably congenital lesions, usually presenting with hemorrhage. Hypervascular low-grade gliomas associated with AVMs were previously called “angioglioma.” An association of AVMs and GBM was also described.
Study Aims We discuss the data of the largest series of locally coincident GBM with AVM in a single institution so far. All analyses were explorative only.
Patients We report a series of four patients presenting at our department from 2006 to 2014. All patients underwent surgery. The cases were analyzed regarding initial presentation, clinical findings, tumor localization, and histopathologic results.
Conclusions A local coincidence of cerebral AVM and GBM is rare. Only a few reports can be found in the literature. The radiologic as well as the clinical presentations are individual. Proangiogenic factors are discussed as involved in the appearance of both entities in the same location. However, the presence of pathologic vessels within malignant gliomas is well known to all neurosurgeons and proangiogenic activity has been proven. Therefore, it seems possible that tumor activity itself contributes to the pathogenesis of a vascular malformation.
Vertebral Body Osteolysis 6 Years After Cervical Disk Arthroplasty
Authors: Harati Ali , Oni Paul , Oles Lucas , Reuter Thomas , Hamdan Mohammad 
Published: January 2020

AbstractCervical arthroplasty is an accepted and widely performed surgical intervention with usually favorable outcomes. We report a rare case of a 37-year-old woman who presented with vertebral body osteolysis, 6 years after two-level cervical arthroplasty (C5–C6 and C6–C7). The patient showed no initial complications, but at year 6 she presented with neck and radicular arm pain. Diagnostic imaging revealed osteolysis of the vertebral body C6. The patient subsequently underwent removal of the two prostheses and C6 corpectomy, followed by bridging C5 to C7 and anterior fixation. During surgery, the mantle of the prostheses appeared broken, with the core expulsed anteriorly and embedded in granulomatous scar tissue. Pathologic evaluation of the samples showed partially proliferating fibroblasts, giant cell reaction, and textile particles. Postoperatively, clinical symptoms resolved with no residual deficits. Additional research should be performed to assess the long-term complications of this procedure that should be included in the patient informed consent materials.
Safety of Prophylactic Heparin in the Prevention of Venous Thromboembolism After Spontaneous Intracerebral Hemorrhage: A Meta-analysis
Authors: Pan Xi , Li Jihui , Xu Lan , Deng Shengming , Wang Zhi 
Published: January 2020

Abstract
Objectives Patients with spontaneous intracerebral hemorrhage (sICH) have a nearly fourfold greater risk for venous thromboembolism (VTE) than those with acute ischemic stroke, and VTE after sICH is associated with high risk for in-hospital mortality. The benefit from prophylactic heparin for VTE remains uncertain because its safety is not documented. In this study, we used an updated meta-analysis to evaluate the safety of heparin for the prevention of VTE in patients with sICH.
Methods Electronic databases Medline and Embase from January 1990 to November 2017 and the Cochrane Library were searched using these keywords: intracerebral hemorrhage, stroke, hemorrhagic stroke, subarachnoid hemorrhage, heparin, heparinoids, low-molecular-weight heparin, anticoagulants, prophylactic, low dose, prevention, deep venous thrombosis, pulmonary embolism, venous thrombosis, randomized controlled trial, controlled clinical trial, and outcome. We evaluated the quality of included studies according to the bias risk in the Cochrane Handbook for Systematic Reviews of Interventions v.5.1.0. All statistical analyses were performed with RevMan v.5 software (Cochrane Collaboration, London, United Kingdom). Tests of heterogeneity were conducted with the Mantel-Haenszel method.
Results Nine studies involving 4,055 patients with sICH met the inclusion criteria in this meta-analysis. Of these studies, only one met all specific criteria and had a low probability of bias, whereas eight studies met only some of the criteria and had a moderate probability of bias. In comparison with non-heparin treatments, low-molecular-weight heparin or unfractionated heparin was associated with a nonsignificant increase in any hematoma enlargement, a nonsignificant reduction in extracranial hemorrhage, a nonsignificant increase in mortality, a nonsignificant increase in the number of modified Rankin Scale scores of 3 to 5, and a nonsignificant increase in numbers of Glasgow Outcome Scale scores of 2 to 3.
Conclusion Prophylactic heparin was associated with a nonsignificant increase in any hematoma enlargement and mortality, a nonsignificant reduction in extracranial hemorrhage, and a nonsignificant increase in the incidence of major disability in patients with sICH. It is probably safe to administer heparin to prevent VTE in patients with sICH.
Foetal type posterior cerebral artery -a case report
Authors: Bala Manju , Kaushal Subhash , Passi Dinesh Kumar 
Published: January 2020

AbstractPosterior cerebral artery (PCA),terminal branch of basilar artery join the posterior communicating artery to complete the circle of Willis. The morphological variations of posterior segment of the circle of Willis are much of importance in the diagnosis & treatment of different cerebrovascular diseases.In a series of anatomical dissections of the cerebral arterial territory in 30 cadaveric brain specimens,an important variation of the precommunicating segment of the posterior cerebral artery Pl was found. In this variation, an embryonic derivation of the posterior cerebral artery from the internal carotid artery (ICA) known as foetal type posterior cerebral artery was seen. This type of variation may lead to the appearance and severity of syndromes of vascular insufficiency in adults.
Molecular mechanism in a rare autosomal recessive case of xeroderma pigmentosum - a case report
Authors: Ramanathan Vijaya , Ramanathan Anand 
Published: January 2020

AbstractChromosomal instability syndromes are a special group of disorders of cytogenetic interest which comprises of several rare, autosomal recessive conditions. Following exposure to sunlight, excessive chromosomal instability, breakage, defective nucleotide excision repair in DNA, defective apoptosis and increased susceptibility to neoplasia occurs. Xeroderma pigmentosum (XP) is characterised by the presence of chromosomal breakages, associated with increased frequency of sister chromatid exchanges. This is a case report of a 6 year old, male child having XP with dermal and ocular manifestations. Chromosomal breaks in chromosomal spread are seen. If it occurs in families, consanguinous marriages should be avoided; appropriate genetic counselling suggested and simple sun guarding techniques with appropriate protection from UV exposure can reduce the morbidity in these patients.
Autoimmune Vestibulocerebellar Syndromes
Authors: Narayan Ram N. , McKeon Andrew , Fife Terry D. 
Published: January 2020

AbstractAutoimmune disorders affecting the vestibular end organs, vestibular pathways, vestibular nuclei, and vestibulocerebellum are often underrecognized as a cause of chronic dizziness and ataxia. Autoantibodies specific for cell-surface, synaptic, and intracellular neural antigens serve as biomarkers of these disorders. This article describes the epidemiology, clinical presentation, diagnostic considerations, imaging findings, treatment, and prognosis of autoimmune disorders, in which the vestibulocerebellar syndrome is the main or presenting clinical presentation. Antibodies specific for intracellular antigenic targets described in the article are PCA-1 (Purkinje cell cytoplasmic antibody type 1, also known as anti-Yo), ANNA-1 (antinuclear neuronal antibody type 1, also known as anti-Hu), ANNA-2 (antinuclear neuronal antibody type 2, also known as anti-Ri), Ma1/2 (anti-Kelch-like 11/12 antibody), Kelch-like 11, amphiphysin, CV2 (collapsin response 2, also known as collapsin response mediator protein-5 [CRMP5]), VGCC (voltage-gated calcium channel), GAD65 (glutamic acid decarboxylase 65-kDa isoform), AP3B2 (adaptor protein 3B2, also known as anti-Nb), MAP1B (microtubule-associated protein 1B antibody, also known as anti-PCA-2), and neurochondrin antibodies. Antibodies targeting cell-surface or synaptic antigenic targets described in the article include DNER (delta/notchlike epidermal growth factor related receptor; antigen to anti-Tr), CASPR2 (contactin-associated proteinlike 2), septin-5, Homer-3, and mGluR1 (metabotropic glutamate receptor 1). The vestibulocerebellar presentation is largely indistinguishable among these conditions and is characterized by subacute onset of cerebellar symptoms over weeks to months. The diagnosis of autoimmune vestibulocerebellar syndromes is based on a combination of clinical and serological features, with a limited role for neuroimaging. Subtle eye movement abnormalities can be an early feature in many of these disorders, and therefore a meticulous vestibulo-ocular examination is essential for early and correct identification. Cancer occurrence and its type are variable and depend on the autoantibody detected and other cancer risk factors. Treatment comprises immunotherapy and cancer-directed therapy. Acute immunotherapies such as intravenous immunoglobulin, plasma exchange, and steroids are used in the initial phase, and the use of long-term immunosuppression such as rituximab may be necessary in relapsing cases. Outcomes are better if immunotherapy is started early. The neurologic prognosis depends on multiple factors.
Multimodal processing in simultaneous interpreting with text
Authors: Chmiel Agnieszka , Janikowski Przemysław , Lijewska Agnieszka 
Published: January 2020

Abstract
The present study focuses on (in)congruence of input between the visual and the auditory modality in simultaneous
interpreting with text. We asked twenty-four professional conference interpreters to simultaneously interpret an aurally and
visually presented text with controlled incongruences in three categories (numbers, names and control words), while measuring interpreting
accuracy and eye movements. The results provide evidence for the dominance of the visual modality, which goes against the
professional standard of following the auditory modality in the case of incongruence. Numbers enjoyed the greatest accuracy across
conditions possibly due to simple cross-language semantic mappings. We found no evidence for a facilitation effect for congruent
items, and identified an impeding effect of the presence of the visual text for incongruent items. These results might be
interpreted either as evidence for the Colavita effect (in which visual stimuli take precedence over auditory ones) or as
strategic behaviour applied by professional interpreters to avoid risk.
Fungal community dynamics during degradation of poly(butylene succinate-co-adipate) film in two cultivated soils in Japan
Authors: Yamamoto-Tamura Kimiko , Hoshino Yuko Takada , Tsuboi Shun , Huang Chuan , Kishimoto-Mo Ayaka Wenhong , Sameshima-Yamashita Yuka , Kitamoto Hiroko 
Published: January 2020

Abstract
Fungi play an important role in the degradation of biodegradable plastics (BPs) in soil. However, little is known about their dynamics in the soil during the degradation of BPs. We studied the community dynamics of BP-degrading fungi during poly(butylene succinate-co-adipate) (PBSA) film degradation in two different types of soils using culture-dependent and culture-independent methods. The Fluvisol and the Andosol soils degrade embedded PBSA films at high and low speeds, respectively. The number of PBSA emulsion-degrading fungi that increased in the Fluvisol soil was higher than that in the Andosol soil after embedding with PBSA films. We succeeded in detecting internal transcribed spacer 1 (ITS1) regions those matched that of the fungi by polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE) in both soils. Our results suggest that fungal community analyses using PCR-DGGE in combination with BP degraders isolation techniques enables the monitoring of BP films-degrading fungi.
Analytical results for the dynamics of parabolic level-crossing model
Authors: Kam Chon-Fai , Chen Yang 
Published: January 2020

Abstract
We study the dynamics of a two-level crossing model with a parabolic separation of the diabatic energies. The solutions are expressed in terms of the tri-confluent Heun equations—the generalization of the confluent hypergeometric equations. We obtain analytical approximations for the state populations in terms of Airy and Bessel functions. Applicable expressions are derived for a large part of the parameter space. We also provide simple formulas which connect local solution in different time regimes. The validity of the analytical approximations is shown by comparing them to numerical simulations.
Preliminary study of fragment simulating projectile on epoxy-ramie composite
Authors: Mukhammad A F H , Murni  , Mujiyono  , Nurhadiyanto D , Hassan S A , Riyadi T W B 
Published: January 2020

Abstract
This research is a preliminary study to determine the feasibility of the ballistic test equipment using fragment-simulating projectiles (FSP) and the ability of the rami-epoxy composite against bullet penetration. Tests have been conducted in which FSP were fired at epoxy ramie composites. Ballistic test equiment was equipped with a chronograph and high speed camera. The composites were manufactured using manual hand lay-up compression moulding 60% volume fraction. Based on the high speed camera result shows that the FSP projectile when crashing into the specimen was not in perfect position (tilted) and the ramieepoxy composite was fail in 6, 9, and 12 layers.
Development of interactive learning media in producing straight gears of milling subjects
Authors: Rahdiyanta D , Prasetya H T , Rezani R 
Published: January 2020

Abstract
This study aims to develop interactive learning media produce straight gears in subjects of milling machining. This type of research is research and development. Media development procedures include the identification stage, the design and development stage, the validation stage, user responses and the final product results. Data collection techniques are done by observation, interviews and questionnares. Data analysis techniques using quantitative descriptive techniques. This research resulted in an interactive learning media produce straight gears at 284 MB in the form of files. exe which is equipped with images, video, audio and animation. Assessment of the appropriateness of interactive learning media produce straight gears from media experts get grades with very good categories, from material experts get assessments with good categories, from teachers get grades in very good categories, and from student responses get grades in very good categories.
The development of mechanical drawing job-sheet for vocational high school instructional
Authors: Nuryanto A , Rahayu N S , Setiadi B R 
Published: January 2020

Abstract
This study aims to develop a mechanical engineering drawing job sheet and determine the feasibility of the media. This research uses research and development by referring to the Four-D development model (define, design, develop, disseminated). Data collection techniques with observation and interviews. The instrument used was a non-test instrument in the form of a closed questionnaire with a Likert scale of five answer choices. The results showed that the job sheet learning media was carried out with several steps, namely defining needs, designing, developing and distributing. The feasibility of the job sheet media for learning engineering drawings based on the results of the validation of media experts has a score of 4.58 and a material expert score of 4.66 which is included in the very feasible category. The results of teacher user responses with a mean score of 4.21 and 4.5 students in a very feasible category.
Analysis of multi-cell hexagonal crash box design with foam filled under frontal load model
Authors: Choiron M A 
Published: January 2020

Abstract
This study aim is to determine the effect of Multi-Hexagonal crash box design variations on energy absorption. The research method used ANSYS Academic software version 18.1. The crash box model analysed consists of 3 models, namely the multi-cell hexagonal outer foam filled crash box, inner foam filled and without foam filled. Crash box testing refers to the instrumented drop mass setup test model, impactor with a mass of 103 kg crashing crash box with a speed of 7.67 m/s. Deformation pattern and energy absorption are observed as design criteria to determine the best crash box design specifications. The simulation results show that the highest energy absorption value is the multi-cell hexagonal outer foam filled crash box with that Ea is 30, 606 kJ. There is a significant difference between the multi-cell hexagonal crash box model with foam filled and without foam filled. The addition of foam filled on the multi-cell hexagonal crash box has important effect to improve energy absorption performance. The deformation pattern that occurs in all three models is concertina mode. Based on the force reaction-displacement curve, it can be denoted the crash box that uses foam filled produces upward trend of curves in the end of the deformation. It can be connected to deformation pattern, folding increment is more identified compared to crash box without foam filled.
The analysis of machining job risk in vocational workshop
Authors: Djatmiko R D , Adhitama R K , Prasetya T A 
Published: January 2020

Abstract
This study was purposed to identify the hazards that might occurred in the machining workshop of Public VHS of 2 Wonosari, identify the probabilities that might occurred in machining workshop of Public VHS of 2 Wonosari, identify the risks that would occur in machining workshop of Public VHS of 2 Wonosari, and recognize how the workshop management, teachers and schools controlled and prevented the risks in the machining workshop, in order to avoid the accidents in the machining workshop of Public VHS of 2 Wonosari. This research was descriptive. Data was obtained through observation, interviews and photographic documentation of machining workshop conditions. The validity of the data was done by testing credibility, dependability and confirmation test. Data analysis was using Miles and Huberman analysis methods, by reducing data, presenting data and drawing the conclusions or verification. The results of the study proved that there were 29 hazards sources which identified in the machining workshops, there were 30 opportunities probability which identified in the machining workshop, there were 31 risks which identified in the workshops if without accurate treatment, and the average of risk control in the machining workshops was 86.0%.