bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term and decentred trajectories of doing history from a global perspective: institutionalization, postcolonial critique, and empiricist approaches, before and after the 1970s
Authors: Naumann Katja 
Published: October 2019

AbstractNotions of the ‘global’ in historiography have a long tradition, and yet they appear to be a novelty. This article shows how older understandings of world history, imbued with Eurocentric presuppositions and universalist metaphysical reasoning, were questioned and revised in a long-term process. Recent criticism of Eurocentrism, linked with postcolonial scholarship, and the development of source-based approaches to study global connections and comparisons are usually recognized as innovations that took shape since the 1970s. In fact, they are rooted in profound conceptual revisions and academic institutionalization, which began much earlier. Based on the development of the field of world history in the United States, this article argues that concepts for a multipolar, interactive, and transcultural history developed from a dialectical and critical move away from older narratives. Historians and area specialists have wrestled for at least half a century with questions and problems that were rediscovered in the global turn of the 1980s and 1990s. Furthermore, the example shows that the field developed in specific trajectories, reflecting local and national institutional academic circumstances, as well as specific socio-political contexts.
Evolution of the Josephine Peridotite Shear Zones: 1. Compositional Variation and Shear Initiation
Authors: Kumamoto Kathryn M. , Warren Jessica M. , Hauri Erik H. 
Published: October 2019

AbstractShear localization in the upper mantle, a necessity for plate tectonics, can have a number of causes, including shear heating, the presence of melt, the development of a strong crystal preferred orientation, and the presence of water. The Josephine Peridotite of southwestern Oregon contains shear zones that provide an excellent opportunity to examine the initiation of shear localization. These shear zones are relatively small scale and low strain compared to many shear zones in peridotite massifs, which typically have extreme grain size reduction indicating extensive deformation. We use major, trace, and volatile element analyses of a large suite of harzburgites from the Fresno Bench shear zones to evaluate the mechanisms leading to shear localization. Lithological evidence and geochemical transects across three shear zones show a complex history of melting, melt addition, and melt‐rock interaction. The distribution of aluminum and heavy rare earth elements across the shear zones suggest that melt flow was focused in the centers of the studied shear zones. Water concentrations in orthopyroxene grains of 180–334 ppm H2O indicate a comparatively high degree of hydration for nominally anhydrous minerals. The correlation of water with aluminum and ytterbium in orthopyroxene is consistent with a melt source for this hydration, suggesting that water equilibrated between the melt and peridotite. The presence of melt and hydration of the host rock provide mechanisms for initial weakening that lead to localized deformation.
Evolution of the Josephine Peridotite Shear Zones: 2. Influences on Olivine CPO Evolution
Authors: Kumamoto Kathryn M. , Warren Jessica M. , Hansen Lars N. 
Published: October 2019

AbstractSeismic anisotropy arises in the upper mantle due to the alignment of olivine crystal lattices and is often used to interpret mantle flow direction. Experiments on the evolution of olivine crystal‐preferred orientation (CPO) have found that the texture that develops is dependent on many factors, including water content, differential stress, preexisting CPO, and deformation kinematics. To evaluate the role of these factors in naturally deformed samples, we present microstructural transects across three shear zones in the Josephine Peridotite. Samples from these shear zones exhibit a mixture of A‐type textures, which have been associated with dry conditions and primary activation of the olivine [100](010) slip system, and of E‐type textures, which have been associated with wetter conditions and primary activation of the [100](001) slip system. CPOs with characteristics of both A‐type and E‐type textures are also present. CPO type does not evolve systematically as a function of either strain or water content. We used a micromechanical model to evaluate the roles of preexisting texture and kinematics on olivine CPO evolution. We find that the preexisting texture controls CPO evolution at strains up to 5 during simple shear. Kinematics involving a combination of simple shear and pure shear can explain the olivine CPOs at higher strain. Hence, preexisting CPOs and deformation kinematics should be considered in the interpretation of CPOs measured in naturally deformed rocks and of large‐scale patterns in upper‐mantle seismic anisotropy.
Ocean‐Wave‐Atmosphere Interaction Processes in a Fully Coupled Modeling System
Authors: Wu Lichuan , Breivik Øyvind , Rutgersson Anna 
Published: October 2019

AbstractA high‐resolution coupled ocean‐wave‐atmosphere model (Uppsala University Coupled model, UU‐CM) of the Baltic Sea and the North Sea with improved representation of ocean‐wave‐atmosphere interaction processes is presented. In the UU‐CM model, the stress on the air‐sea interface is estimated as a balance of four stress terms, that is, the air‐side stress, ocean‐side stress, wave‐supported stress (absorption of momentum by the wave field), and the momentum flux from waves to currents (breaking waves). The vector differences between these four stress terms are considered in the coupled system. The turbulent kinetic energy flux induced by wave breaking, the Stokes‐Coriolis force and the Stokes drift material advection terms are added to the ocean circulation model component. Based on two‐month‐long (January and July) simulations, we find that the ocean‐wave‐atmosphere coupling has a significant influence on coastal areas. The coupled system captures the influence of surface currents and local systems such as coastal upwelling and their impact on the atmosphere. The wave‐current interaction enhances the upper ocean mixing and reduces the sea surface temperature in July significantly. However, the pattern of the wave‐current processes influences on the ocean current and waves are complex due to the stress differences in both magnitude and direction.
Precision medicine by designer interference peptides: applications in oncology and molecular therapeutics
Authors: Sorolla Anabel , Wang Edina , Golden Emily , Duffy Ciara , Henriques Sónia T. , Redfern Andrew D. , Blancafort Pilar 
Published: October 2019

AbstractIn molecular cancer therapeutics only 10% of known cancer gene products are targetable with current pharmacological agents. Major oncogenic drivers, such as MYC and KRAS proteins are frequently highly overexpressed or mutated in multiple human malignancies. However, despite their key role in oncogenesis, these proteins are hard to target with traditional small molecule drugs due to their large, featureless protein interfaces and lack of deep pockets. In addition, they are inaccessible to large biologicals, which are unable to cross cell membranes. Designer interference peptides (iPeps) represent emerging pharmacological agents created to block selective interactions between protein partners that are difficult to target with conventional small molecule chemicals or with large biologicals. iPeps have demonstrated successful inhibition of multiple oncogenic drivers with some now entering clinical settings. However, the clinical translation of iPeps has been hampered by certain intrinsic limitations including intracellular localization, targeting tissue specificity and pharmacological potency. Herein, we outline recent advances for the selective inhibition of major cancer oncoproteins via iPep approaches and discuss the development of multimodal peptides to overcome limitations of the first generations of iPeps. Since many protein–protein interfaces are cell-type specific, this approach opens the door to novel programmable, precision medicine tools in cancer research and treatment for selective manipulation and reprogramming of the cancer cell oncoproteome.
Bi-allelic variants in RNF170 are associated with hereditary spastic paraplegia
Authors: Wagner Matias , Osborn Daniel P. S. , Gehweiler Ina , Nagel Maike , Ulmer Ulrike , Bakhtiari Somayeh , Amouri Rim , Boostani Reza , Hentati Faycal , Hockley Maryam M. , Hölbling Benedikt , Schwarzmayr Thomas , Karimiani Ehsan Ghayoor , Kernstock Christoph , Maroofian Reza , Müller-Felber Wolfgang , Ozkan Ege , Padilla-Lopez Sergio , Reich Selina , Reichbauer Jennifer , Darvish Hossein , Shahmohammadibeni Neda , Tafakhori Abbas , Vill Katharina , Zuchner Stephan , Kruer Michael C. , Winkelmann Juliane , Jamshidi Yalda , Schüle Rebecca 
Published: October 2019

AbstractAlterations of Ca2+ homeostasis have been implicated in a wide range of neurodegenerative diseases. Ca2+ efflux from the endoplasmic reticulum into the cytoplasm is controlled by binding of inositol 1,4,5-trisphosphate to its receptor. Activated inositol 1,4,5-trisphosphate receptors are then rapidly degraded by the endoplasmic reticulum-associated degradation pathway. Mutations in genes encoding the neuronal isoform of the inositol 1,4,5-trisphosphate receptor (ITPR1) and genes involved in inositol 1,4,5-trisphosphate receptor degradation (ERLIN1, ERLIN2) are known to cause hereditary spastic paraplegia (HSP) and cerebellar ataxia. We provide evidence that mutations in the ubiquitin E3 ligase gene RNF170, which targets inositol 1,4,5-trisphosphate receptors for degradation, are the likely cause of autosomal recessive HSP in four unrelated families and functionally evaluate the consequences of mutations in patient fibroblasts, mutant SH-SY5Y cells and by gene knockdown in zebrafish. Our findings highlight inositol 1,4,5-trisphosphate signaling as a candidate key pathway for hereditary spastic paraplegias and cerebellar ataxias and thus prioritize this pathway for therapeutic interventions.
Mapping the global design space of nanophotonic components using machine learning pattern recognition
Authors: Melati Daniele , Grinberg Yuri , Kamandar Dezfouli Mohsen , Janz Siegfried , Cheben Pavel , Schmid Jens H. , Sánchez-Postigo Alejandro , Xu Dan-Xia 
Published: October 2019

AbstractNanophotonics finds ever broadening applications requiring complex components with many parameters to be simultaneously designed. Recent methodologies employing optimization algorithms commonly focus on a single performance objective, provide isolated designs, and do not describe how the design parameters influence the device behaviour. Here we propose and demonstrate a machine-learning-based approach to map and characterize the multi-parameter design space of nanophotonic components. Pattern recognition is used to reveal the relationship between an initial sparse set of optimized designs through a significant reduction in the number of characterizing parameters. This defines a design sub-space of lower dimensionality that can be mapped faster by orders of magnitude than the original design space. The behavior for multiple performance criteria is visualized, revealing the interplay of the design parameters, highlighting performance and structural limitations, and inspiring new design ideas. This global perspective on high-dimensional design problems represents a major shift in modern nanophotonic design and provides a powerful tool to explore complexity in next-generation devices.
Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters
Authors: Zhang Kaixi , Du Yu , Si Zhangyong , Liu Yang , Turvey Michelle E. , Raju Cheerlavancha , Keogh Damien , Ruan Lin , Jothy Subramanion L. , Reghu Sheethal , Marimuthu Kalisvar , De Partha Pratim , Ng Oon Tek , Mediavilla José R. , Kreiswirth Barry N. , Chi Yonggui Robin , Ren Jinghua , Tam Kam C. , Liu Xue-Wei , Duan Hongwei , Zhu Yabin , Mu Yuguang , Hammond Paula T. , Bazan Guillermo C. , Pethe Kevin , Chan-Park Mary B. 
Published: October 2019

AbstractThe treatment of bacterial infections is hindered by the presence of biofilms and metabolically inactive persisters. Here, we report the synthesis of an enantiomeric block co-beta-peptide, poly(amido-D-glucose)-block-poly(beta-L-lysine), with high yield and purity by one-shot one-pot anionic-ring opening (co)polymerization. The co-beta-peptide is bactericidal against methicillin-resistant Staphylococcus aureus (MRSA), including replicating, biofilm and persister bacterial cells, and also disperses biofilm biomass. It is active towards community-acquired and hospital-associated MRSA strains which are resistant to multiple drugs including vancomycin and daptomycin. Its antibacterial activity is superior to that of vancomycin in MRSA mouse and human ex vivo skin infection models, with no acute in vivo toxicity in repeated dosing in mice at above therapeutic levels. The copolymer displays bacteria-activated surfactant-like properties, resulting from contact with the bacterial envelope. Our results indicate that this class of non-toxic molecule, effective against different bacterial sub-populations, has promising potential for the treatment of S. aureus infections.
Photonic crystal for graphene plasmons
Authors: Xiong L. , Forsythe C. , Jung M. , McLeod A. S. , Sunku S. S. , Shao Y. M. , Ni G. X. , Sternbach A. J. , Liu S. , Edgar J. H. , Mele E. J. , Fogler M. M. , Shvets G. , Dean C. R. , Basov D. N. 
Published: October 2019

AbstractPhotonic crystals are commonly implemented in media with periodically varying optical properties. Photonic crystals enable exquisite control of light propagation in integrated optical circuits, and also emulate advanced physical concepts. However, common photonic crystals are unfit for in-operando on/off controls. We overcome this limitation and demonstrate a broadly tunable two-dimensional photonic crystal for surface plasmon polaritons. Our platform consists of a continuous graphene monolayer integrated in a back-gated platform with nano-structured gate insulators. Infrared nano-imaging reveals the formation of a photonic bandgap and strong modulation of the local plasmonic density of states that can be turned on/off or gradually tuned by the applied gate voltage. We also implement an artificial domain wall which supports highly confined one-dimensional plasmonic modes. Our electrostatically-tunable photonic crystals are derived from standard metal oxide semiconductor field effect transistor technology and pave a way for practical on-chip light manipulation.
Archaeometallurgical investigation of ancient artefacts’ degradation phenomenon
Authors: Dwivedi Deepak , Mata Jitendra P. 
Published: October 2019

AbstractArchaeomaterials suffer from various degradation such as atmospheric corrosion, under-deposit corrosion and underwater corrosion etc.; however, the extent of degradation depends on the composition of materials, environment, manufacturing process and post-processing technology such as surface treatment like carburization etc. The corrosion (degradation) phenomenon of ferrous artefacts is very complex and has received significant attention for understanding the ancient metal technology and for designing the conservation pathway of historical artefacts. This review highlights the mechanism of degradation under different environments and also paves a path for the future studies by using different analytical techniques to advance the existing knowledge.
The Alteration Mechanism of Copper-bearing Biotite and Leachable Property of Copper-bearing Minerals in Mulyashy Copper Mine, Zambia
Authors: Wang Gai-rong , Yang Hong-ying , Liu Yuan-yuan , Tong Lin-lin , Auwalu Ali 
Published: October 2019

AbstractThe XRF, XRD, polarizing microscopy and SEM-EDS were used to study the alteration mechanism of copper-bearing biotite and the leachable property of copper-bearing minerals in Mulyashy Copper Mine, Zambia. It was found that biotite can be divided into copper-bearing biotite and copper-free biotite. Some copper-bearing biotite existed in the form of monomer, and others aggregated with copper-bearing chlorite, malachite or copper-bearing limonite. The main reason for the occurrence of biotite aggregations was that copper-bearing biotite underwent two kinds of alteration mechanisms as follows: altering into copper-bearing chlorite and malachite, and altering into copper-bearing chlorite and copper-bearing limonite. The order of factors effecting the copper leaching rate of the ores in acid leaching experiments was temperature > sample size > H2SO4 concentration > leaching time > stirring speed. In addition, the copper leaching rate of copper-bearing minerals at different temperatures was in the following order: malachite, chrysocolla and pseudomalachite > copper-bearing chlorite > copper-bearing muscovite > copper-bearing biotite > copper-bearing limonite. The leachable property of biotite is closely related to its special structure.
Binding site plasticity in viral PPxY Late domain recognition by the third WW domain of human NEDD4
Authors: Iglesias-Bexiga Manuel , Palencia Andrés , Corbi-Verge Carles , Martin-Malpartida Pau , Blanco Francisco J. , Macias Maria J. , Cobos Eva S. , Luque Irene 
Published: October 2019

AbstractThe recognition of PPxY viral Late domains by the third WW domain of the HECT-E3 ubiquitin ligase NEDD4 (hNEDD4-WW3) is essential for the completion of the budding process of numerous enveloped viruses, including Ebola, Marburg, HTLV1 or Rabies. hNEDD4-WW3 has been validated as a promising target for the development of novel host-oriented broad spectrum antivirals. Nonetheless, finding inhibitors with good properties as therapeutic agents remains a challenge since the key determinants of binding affinity and specificity are still poorly understood. We present here a detailed structural and thermodynamic study of the interactions of hNEDD4-WW3 with viral Late domains combining isothermal titration calorimetry, NMR structural determination and molecular dynamics simulations. Structural and energetic differences in Late domain recognition reveal a highly plastic hNEDD4-WW3 binding site that can accommodate PPxY-containing ligands with varying orientations. These orientations are mostly determined by specific conformations adopted by residues I859 and T866. Our results suggest a conformational selection mechanism, extensive to other WW domains, and highlight the functional relevance of hNEDD4-WW3 domain conformational flexibility at the binding interface, which emerges as a key element to consider in the search for potent and selective inhibitors of therapeutic interest.
Ole e 15 and its human counterpart -PPIA- chimeras reveal an heterogeneous IgE response in olive pollen allergic patients
Authors: San Segundo-Acosta Pablo , Oeo-Santos Carmen , Navas Ana , Jurado Aurora , Villalba Mayte , Barderas Rodrigo 
Published: October 2019

AbstractOlive pollen is a major cause of immunoglobulin E (IgE)-mediated allergy in Mediterranean countries. It is expected to become a worldwide leading allergenic source because olive cultivation is increasing in many countries. Ole e 15 belongs to the cyclophilin pan-allergen family, which includes highly cross-reactive allergens from non-related plant, animal and mold species. Here, the amino acid differences between Ole e 15 and its weak cross-reactive human homolog PPIA were grafted onto Ole e 15 to assess the contribution of specific surface areas to the IgE-binding. Eight Ole e 15-PPIA chimeras were produced in E. coli, purified and tested with 20 sera from Ole e 15-sensitized patients with olive pollen allergy by ELISA experiments. The contribution of linear epitopes was analyzed using twelve overlapping peptides spanning the entire Ole e 15 sequence. All the patients displayed a diverse reduction of the IgE-reactivity to the chimeras, revealing a highly polyclonal and patient-specific response to Ole e 15. IgE-epitopes are distributed across the entire Ole e 15 surface. Two main surface areas containing relevant conformational epitopes have been characterized. This is the first study to identify important IgE-binding regions on the surface of an allergenic cyclophilin.
Ageing deformation of tailings dams in seasonally frozen soil areas under freeze-thaw cycles
Authors: Jin Jiaxu , Li Shiwang , Song Chenguang , Zhang Xinlei , Lv Xiangfeng 
Published: October 2019

AbstractThe freeze-thaw cycle is one of the important factors in inducing a dam-break in the permafrost region, so it is of great practical significance to study the mechanism of the failure deformation of tailings dams under freeze-thaw cycles. In this paper, the water-heat-force coupling model of a tailings dam considering frost-thaw damage is established, and the freeze-thaw cyclic ageing deformation of a tailings dam in a seasonally frozen soil area is studied. The correctness of the model is validated by numerical calculation. The research shows under the same water content, the compressive strength and modulus of deformation decrease with an increase in the number of freeze-thaw cycles, the cohesion and internal friction angle decrease, and the amplitude gradually decreases before becoming stable. In the process of cooling, the pore water pressure first increases and then decreases, and the pore water pressure first decreases and then increases during the heating process. The research results can provide a theoretical basis and reference values for the stability analysis of tailings dams in seasonally frozen soil areas.
Intelligence artificielle : le futur de l’Orthodontie ?
Authors: Foucart Jean-Michel , Chavanne Augustin , Bourriau Jérôme 
Published: October 2019

Nombreux sont les apports envisagés de l’Intelligence Artificielle (IA) en médecine. En orthodontie, plusieurs solutions automatisées sont disponibles depuis quelques années en imagerie par rayons X (analyse céphalométrique automatisée, analyse automatisée des voies aériennes) ou depuis quelques mois (analyse automatique des modèles numériques, set-up automatisé; CS Model +, Carestream Dental™).
L’objectif de cette étude, en deux parties, est d’évaluer la fiabilité de l’analyse automatisée des modèles tant au niveau de leur numérisation que de leur segmentation.
La comparaison des résultats d’analyse des modèles obtenus automatiquement et par l’intermédiaire de plusieurs orthodontistes démontre la fiabilité de l’analyse automatique; l’erreur de mesure oscillant, in fine, entre 0,08 et 1,04 mm, ce qui est non significatif et comparable avec les erreurs de mesures inter-observateurs rapportées dans la littérature.
Ces résultats ouvrent ainsi de nouvelles perspectives quand à l’apport de l’IA en Orthodontie qui, basée sur le deep learning et le big data, devrait permettre, à moyen terme, d’évoluer vers une orthodontie plus préventive et plus prédictive.
Berufskrankheiten in der Hausarztpraxis
Authors: Fuchs Stephan , Janssen Jörg 
Published: October 2019

AbstractThis article shows an overview of occupational diseases. You can find a lot of these diseases in family practice. For treatment of occupational diseases specialists can be consulted. It is a big challenge to detect diseases caused by work influence. This is what you should do: inquire specifically about newly diagnosed illness after work. Ask about the current occupation and previous occupational activities. Already report the suspicion of an occupational disease to the competent authority. For every occupational disease, there is a leaflet with scientific basics, explanation of occupational stress and its impact on the body. Remedies and aids may not be prescribed by family doctors at the expense of the statutory health insurance.