bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drug Synergy Prediction Using Dynamic Mutation Based Differential Evolution
Authors: Kaur Manjit , Singh Dilbag , Kumar Vijay 
Published: November 2020

Purpose:
In cancer therapies, drug combinations have shown significant accuracy and minimal side
effects than the single drug administration. Therefore, drug synergy has drawn great interest from
pharmaceutical companies and researchers. Unfortunately, the prediction of drug synergy score was carried out
based on the small group of drugs.

Methods:
Due to the advancement in high-throughput screening (HTS), the size of drug synergy datasets has
grown enormously in recent years. Hence, machine learning models have been utilized to predict the drug
synergy score. However, the majority of these machine learning models suffer from over-fitting and hyperparameters
tuning issues.

Results:
A novel deep bidirectional mixture density network (BMDN) model is proposed. A dynamic mutationbased
multi-objective differential evolution is used to optimize the hyper-parameters of BMDN. Extensive is
conducted on the NCI-ALMANAC drug synergy dataset that consists of 2,90,000 synergy determinations.

Conclusions:
Experimental results reveal that BMDN outperforms the existing drug synergy models in terms of
various performance metrics.
Properties of Ethnomedicinal Plants and Their Bioactive Compounds: Possible Use for COVID-19 Prevention and Treatment
Authors: Shoaib Ambreen , Azmi Lubna , Shukla Ila , Alqahtani Saad S. , Alsarra Ibrahim A. , Shakeel Faiyaz 
Published: November 2020

Background:
The coronavirus disease 2019 (COVID-19) pandemic has changed the global scenario.
To date, there are no treatment or preventive options. The discovery of a new drug will take time. In addition,
the new drug will have side effects, and the virus will gradually become resistant to it. Therefore, it is important
to search for a drug with a natural origin.

Objective:
In this review, we analyzed and summarized various ethnomedicinal plants and their bioactive compounds
as a source of antiviral agents for COVID-19 prevention and treatment.

Methods:
From the literature, we selected different natural compounds that can act as potential targets at low
cost with broad-spectrum antiviral activity.

Results:
Of the 200 Chinese herbal extracts tested for their possible role against SARS-CoV, Lycoris radiata,
Artemisia annua, Pyrrosia lingua, and Lindera aggregate showed anti-SARS-CoV effects with the median effective
concentration = 2.4-88.2 μg/mL.

Conclusion:
Ethnomedicinal herbs can be used as an alternative source of novel, promising antiviral agents that
might directly or indirectly inhibit the COVID-19 progression.
Ultrasound-Assisted One-Pot Synthesis of Tetrahydropyrimidne Derivatives through Biginelli Condensation: A Catalyst Free Green Chemistry Approach
Authors: Patel Ashish , Shah Jinagna , Patel Kesha , Patel Krishna , Patel Harit , Dobaria Divyesh , Shah Umang , Patel Mehul , Chokshi Avani , Patel Samir , Parekh Nikunj , Shah Hirak , Patel Harnisha , Bambharoliya Tushar 
Published: November 2020

The aim of present work is one-pot catalyst free green synthesis of tetrahydropyrimidne derivatives
through Biginelli condensation under ultrasonic irradiation.

The chemical applications of ultrasound, "sonochemistry", has become an exciting new field of research
during the past decade as it can increase reactivities by nearly a million fold. Owing to the increasing
use of Green technology approach, due to its various merits over Classical methodology and
as a need for sustainable Chemistry, this reaction has received renewed interest for preparing tetrahydropyrimidine
(THPM) through Biginelii condensation in an environmentally thoughtful manner with
improved yields.

The objective of the present study is focused on developing novel Ultrasound-Assisted catalyst free
one-pot synthesis of tetrahydropyrimidne derivatives through Biginelli condensation
We, herein describe a highly efficient catalyst free one-pot green synthesis of tetrahydropyrimidine derivatives
using Biginelli protocol under ultrasonic irradiation at 50°C. All the products were characterized
by comparing their physical and spectral data with those of authentic compounds reported in the
literature.

:
A green and efficient ultrasound-assisted one-pot synthesis method for tetrahydro-yrimidine
derivatives have been developed through Biginelli condensation. The technique affords up to 99%
yield in only 5–20 minutes under mild heating. Each synthesized compounds were fully characterized
through spectral techniques viz. IR, 1H NMR, and Mass Spectroscopy.

A green and efficient ultrasound-assisted one-pot synthesis method for tetrahy-droyrimidine
derivatives have been developed through Biginelli condensation. The present sonochemistry based
green chemistry approach with no additional acid catalyst produces no waste, shows a significant
enhancement in reaction rates under mild ultrasound irradiation in excellent yields and therefore
represents a green and enviro-economic synthetic methodology for the Biginelli condensation in
comparison to conventional heating/micro-wave irradiation.
Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry
Authors: Ferreira Vitor F. , de Carvalho Alcione S. , Ferreira Patricia G. , Lima Carolina G.S. , de C. da Silva Fernando 
Published: November 2020

Background:
Several quinones are on the pharmaceutical market as drugs for the treatment of several diseases.

Objective:
The aim of this review was to provide an overview on the quinones that have become drugs for several therapeutic applications.

Method:
We have comprehensively and critically discussed all the information available in the literature about quinonebased drugs.

Results:
In this review, the various aspects of the chemistry and biochemistry of these drugs are highlighted,
including their repositioning, drug combination and their new uses.

Conclusion:
The number of studies related to quinone drugs for different pharmaceutical uses shows that the interest in new
applications still increasing in recent years.
Properties and Applications of Modified Bacterial Cellulose-Based Materials
Authors: Badshah Munair , Ullah Hanif , Wahid Fazli , Khan Taous 
Published: November 2020

Background:
Bacterial cellulose (BC) is the purest form of cellulose as it is free from
pectin, lignin, hemicellulose and other active constituents associated with cellulose derived from
plant sources. High biocompatibility and easy molding into the desired shape make BC an ideal candidate
for applications in the biomedical fields, such as tissue engineering, wound healing and bone
regeneration. In addition to this, BC has been widely studied for applications in the delivery of proteins
and drugs in various forms via different routes. However, BC lacks therapeutic properties and
resistance to the free movement of small molecules, i.e., gases and solvents. Therefore, modification
of BC is required to meet the research ad market demand.

Methods:
We have searched the updated data relevant to as-synthesized and modified BC, properties and applications in
various fields using Web of science, Science direct, Google and PubMed.

Results:
As-synthesized BC possesses properties such as high crystallinity, well organized fibrous network, higher degree
of polymerization, and ability of being produced in swollen form. The large surface area with abundance of free accessible
hydroxyl groups makes BC an ideal candidate for carrying out surface functionalization to enhance its features. The
various reported surface modification techniques including, but not limited to, are amination, methylation and acetylation.

Conclusion:
In this review, we have highlighted various approaches made for BC surface modification. We have also
reported enhancement in the properties of modified BC and potential applications in different fields ranging from
biomedical science to drug delivery and paper-making to various electronic devices.
Human Papillomavirus E7 Oncoprotein Promotes Proliferation and Migration through the Transcription Factor E2F1 in Cervical Cancer Cells
Authors: Tian Sijuan , Zhang Li , Li Yang , Cao Di , Quan Shimin , Guo Yanping , Yang Xiaofeng , Yang Ting 
Published: November 2020

Background:
High-Risk Human Papillomavirus (HR-HPV) persistent infection is the main cause of
cervical cancer and its precancerous lesions. A previous study showed that HPV16 and HPV58 infections were
the most common infection types in the local region. Some studies also declared that HPV58 E7 variants
increased the risk of cervical cancer among Asian populations.

Objective:
This study aimed to determine whether the HPV58 E7 T20I (C632T) variant promotes the malignant
behavior of cervical cancer cells and the underlying mechanism of the HR-HPV E7 oncoprotein involved in the
development of cervical cancer.

Methods:
CCK-8 and clone formation assays were used to detect cell proliferation ability. Transwell assays and
cell wound healing assays were used to evaluate cell migration ability. Targeted knockdown of E2F1 expression
using specific siRNA, RT-qPCR and Western blot were performed to assess gene expression changes. A
chromatin immunoprecipitation assay was used to verify that E2F1 interacted with the TOP2A promoter region.

Results:
HPV58 E7 and HPV58 E7M oncoproteins increased the proliferation and migration ability of cervical
cancer cells. However, the HPV58 E7 T20I variant did not promote malignant behaviors compared with wildtype
HPV58 E7. HPV E7 and E7M oncoproteins increased the expression of TOP2A, BIRC5 and E2F1, and
knockdown of HPV E7 decreased their expression. Low E2F1 expression reduced the expression of TOP2A and
BIRC5 and inhibited the proliferation and migration ability of cervical cancer cells. E2F1 interacted with the
TOP2A gene promoter region to promote its transcriptional expression.

Conclusions:
The HPV58 E7 T20I variant did not promote malignant behaviors compared with wild-type HPV58
E7. The HR-HPV E7 oncoprotein enhanced the proliferation and migration of cervical cancer cells, which was
considered to be due to the HPV E7 oncoprotein, increasing the expression of BIRC5 and TOP2A by
upregulating the transcription factor E2F1.
Effect of Dasatinib on Genes Related to Mitotic Catastrophe Pathway in Chronic Myeloid Leukemia Cells
Authors: Kipcak Sezgi , Ozel Buket , Avci Cigir B. , Takanlou Leila S. , Takanlou Maryam S. , Gunduz Cumhur , Gunel Nur S. 
Published: November 2020

Background:
Chronic Myeloid Leukemia (CML) is characterized by a reciprocal translocation t(9;22)
and forms BCR/ABL1 fusion gene called the Philadelphia chromosome. The therapeutic targets for CML patients
mediated with BCR/ABL1 oncogenic are tyrosine kinase inhibitors such as imatinib, dasatinib, and nilotinib. The
latter two of which have been approved for the treatment of imatinib-resistant or intolerance CML patients.
Mitotic Catastrophe (MC) is one of the non-apoptotic mechanisms initiated in types of cancer cells in response to
anti-cancer therapies. Pharmacological inhibitors of G2 checkpoint members or genetic suppression of PLK1,
PLK2, ATR, ATM, CHK1, and CHK2 can trigger DNA-damage-stimulated mitotic catastrophe. PLK1 and
AURKA/B are anomalously expressed in CML cells, where phosphorylation and activation of PLK1 occur by
AURKB at centromeres and kinetochores.

Objective:
The purpose of this study is to investigate the effect of dasatinib on the expression of genes in MC and
apoptosis pathways in K562 cells.

Methods:
Total RNA was isolated from K-562 cells treated with the IC50 value of dasatinib and untreated cells as
a control group. The expression of MC and apoptosis-related genes, was analyzed by the qRT-PCR system.

Results:
The array-data demonstrated that dasatinib-treated K562 cells significantly caused the decrease of
several genes (AURKA, AURKB, PLK, CHEK1, MYC, XPC, BCL2, and XRCC2).

Conclusion:
The evidence supplies a basis to support clinical researches for the suppression of oncogenes such
as PLKs with AURKs in the treatment of types of cancer, especially chronic myeloid leukemia.
Withdrawal Notice: Electrophoresis as a Tool for Early Cancer Diagnosis
Authors: Aboulthana Wael M. , Sahu Ram K. , Saleh Mahmoud H. 
Published: November 2020

The article has been withdrawn by the Editorial office of the journal Anti-Cancer Agents in Medicinal
Chemistry; because of the lack of clarity and obscurity in the content regarding language.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

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Detecting Faults in VSC-HVDC Systems by Deep Learning and K-means
Authors: Goughari Roohollah Sadeghi , Shahbazzadeh Mehdi Jafari , Eslami Mahdiyeh 
Published: November 2020

Background:
In this paper, two methods and their comparison used to determine the fault locaton in VSC-HVDC transmission lines. Fast and reliable control are features of these systems.

Methods:
Additionally, wavelet transform from advanced techniques of signal processing is employed for the purpose of extracting important characteristics of fault signal from both sides of the line by PMU. To do so, Deep learning is used to identify the relation between the extracted features from wavelet analysis of the fault current and variations under fault conditions. As such, wavelet transform and advanced signal processing techniques are used to extract important features of fault signal from both sides of the line by the PMU.

Results:
The results show the high accuracy of finding fault location by the deep learning algorithm method compared to the k-means algorithm with an error rate of <1%.

Conclusion:
Studies on the 50 kV VSC-HVDC transmission line with a length of 25 km in MATLAB have been simulated.
Extension of Antenna Matching Frequency Band Using Reactive Elements
Authors: Verba B. P. , Shishakov K. V. 
Published: November 2020

Системно рассмотрены традиционные подходы к расширению частотных полос согласования антенн с помощью реактивных цепей. Обсуждены критерии эффективности и особенности синтеза согласующих контуров. Проанализирована оценка предельного расширения частотной полосы пассивного согласования антенн контурами на реактивных элементах. Независимо от сложности и количества согласующих контуров получаемая полоса пассивного согласования ограничивается некоторой областью, размер которой обратно пропорционален добротности согласуемой антенны. Показано, что несколько расширить ее для высокодобротных антенн можно с помощью введения резистивных элементов в дополнительные одноконтурные согласующие модули.Рассмотрен синтез активно настраиваемых тюнеров на реактивных элементах для согласования широкополосных радиотерминалов, и выполнен анализ процессов автоматического регулирования в нем. Показано, что их структурная сложность и эффективность работы тоже зависят от добротности антенн.Приведена методика синтеза согласующей цепи для пассивного узкополосного согласования на нескольких частотах для многодиапазонных антенн. Сначала выбирается основная структура согласующей цепи, и для требуемых частот находятся ее реактивные сопротивления и реактивные проводимости. Далее наборы этих реактивных сопротивлений и проводимостей реализуются через синтез реактивных структур в виде первой и второй форм Фостера.Выполнено моделирование влияния выбора структуры согласующего устройства на расширение частотной полосы согласования высокодобротных антенн. При синтезе многоконтурных согласующих структур методом пробного моделирования небольшие преимущества получены у структур с параллельным соединением последовательных контуров.
Application of selective polymeric sorbents for simple coumarins extraction from deodorant samples
Authors: Hroboňová Katarína , Špačková Andrea 
Published: November 2020

Abstract
Coumarins (2H-1-benzopyran-2-coumarin derivatives) are derivatives of cinnamic acid naturally occurring in many plants, fungi, and fruits. They are used as ingredients in cosmetics to enhance the aroma and other biological effects. In this work, cosmetic samples (deodorants) were treated by solid phase extraction prior to high performance liquid chromatography determination of coumarins. Traditional sorbent (C18) and selective polymer-based sorbents (laboratory prepared and commercial) were used for solid phase extraction. Recovery values were above 85 % (RSDs below 6 %) except for esculin, where the recovery was lower. Core-shell column of C18 type and gradient of mobile phase methanol—1 % acetic acid were used for high performance liquid chromatography analysis of extracts. Limits of quantitation were 0.5 µg mL−1 for coumarin (ultraviolet detection) and below 12 ng mL−1 for esculin, umbelliferonene, scoparone, 4-methylumbelliferone, herniarin (fluorescence detection). In the tested samples, no coumarins were detected.
Dechloromethylation of the berberine to berberrubine — tricks to obtain pure product
Authors: Milata Viktor , Holúbková Eva 
Published: November 2020

Abstract
Berberine (1), as a compound with interesting biological activities, can be modified at various positions to obtain more potent substances. Modifications at position 9 are based on demethylation with simultaneous dechloration resulting in berberrubine. The most frequent process is thermal dechloromethylation and this work describes this method with detailed tricks to obtain almost pure product in high yield.
First Case of Cancrum Oris (Noma) in an HIV-Positive Patient in Bulgaria
Authors: Grozdeva R. , Strashimirov D. , Timchev A. , Tchervenyakova T. , Yancheva N. 
Published: November 2020

Abstract
We present a case of a necrotising disease of the orofacial tissues, the so-called noma, in a female patient with AIDS in a stage of severe immune deficiency. To our knowledge, this is the first time a case like that has been reported in Bulgaria. The patient received an antibiotic course of treatment with a triple combination to good effect on the inflammatory process, and began also HAART. Within 3 weeks, the patient’s general condition improved. However, despite the treatment, a demarcation line was formed, and a defect on the lower lip occurred. Noma is a manifestation of severe immune deficiency with lasting adverse consequences for the patient: severe deformation of the maxilo-facial region and functional impairment (i.e. difficulties eating and speaking, and salivary leak).
COVID-19 Associated Coagulopathy and Implications for its Treatment
Authors: Cherneva Zh. , Cherneva R. 
Published: November 2020

Abstract
The SARS-CoV-2 coronavirus (COVID-19) pandemic is due to lack of prior immunity and there is no certain management, regarding the complications of this viral illness. The target organ for COVID-19 infection are the lungs. Patients may develop acute lung injury that can be complicated by acute respiratory failure, as well as multiorgan failure. The pathophysiology of COVID-19 infection is characterized with inflammatory changes, associated with coagulopathy. Recent data suggests diffuse bilateral pulmonary inflammation observed in COVID-19 infection that is related to a novel pulmonary-specific vasculopathy, defined as pulmonary intravascular coagulopathy (PIC), distinct from disseminated intravascular coagulopathy (DIC). The coagulopathy associated with COVID-19 is distinguished by initial elevation of D-dimer and fibrin/fibrinogen degradation products. Abnormalities in prothrombin time (PT), partial thromboplastin time (APTT) and platelet counts are not common in the early stages of the infection. This suggests the early screening measurement of D-dimer and fibrinogen. The implications for COVID-19-associated-coagulopathy is the established thromboembolic prophylaxis and standard management for sepsis-induced coagulopathy or DIC. High levels of D-dimer are a marker of higher mortality risk. However, current studies do not show the common use of full therapeutical doses of anticoagulants, unless there are other clinical indications. Bleeding in COVID-19 infection is uncommon, even when a laboratory constellation for DIC is present. However, if it occurs, standard guidelines for DIC management should be followed.
Comparative effect of genotype and season on the haematological profile of two laying chicken strains in southwest Nigeria
Authors: Irivboje Young Imienwain , Fafiolu Adeboye Olusesan , Sanni Muyideen Timothy , Irivboje Oluwabusayo Adewunmi , Ikeobi Christian Obiora Ndubuisi 
Published: November 2020

Abstract
Haematological studies help in understanding the relationship of blood characteristics to the environment. One of the major environmental factors influencing haematological indicators is season. This study was aimed at the variation in haematological profiles of two strains of laying birds at different seasons. We therefore evaluated the effects of genotype and season on the haematological profile in two strains of laying birds – Dominant brown (D-192) and Hyline brown in the tropics. A total of 50 birds per strain at 30 weeks of age were randomly selected for this study. Packed cell volume (PCV) and platelets were obtained using microhaematocrit whereas red blood cells (RBC) and white blood cells (WBC) were counted using a haemocytometer. The result obtained showed that there was a significant difference (P < 0.05) in the haematological profile of the birds in the two seasons compared (rainy and dry seasons). The haematological indices obtained during the rainy season had significantly higher mean values in packed cell volume (29.65 ± 0.32%), red blood cells (2.65 ± 0.03 × 1012/L), haemoglobin (100.1 ± 0.11 g/L) and eosinophil (2.5 ± 0.16%) while those obtained during the dry season had a higher significant effect on the white blood cells (19.16 ± 0.36 × 109/L). The results further revealed that between the strains, there was no significant difference (P > 0.05) in most of the indicators analysed but Hyline brown had significantly higher values (P < 0.05) of eosinophils and platelets. We concluded that the observed differences could be a result of genetic differences between the two strains of birds which gives room for selection and that the rainy season is more favourable for laying birds production under tropical condition.