bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variation Over Time and Factors Associated With Detection Rates of Sessile Serrated Lesion Across the United States: Results Form a National Sample Using the GIQuIC Registry
Authors: Shaukat Aasma , Holub Jennifer , Greenwald David , Eisen Glenn , Schmitt Colleen 
Published: August 2020

INTRODUCTION:
Sessile serrated lesions (SSLs) are important precursor lesions for the CpG island–methylated pathway to colorectal cancer. The reported detection rates of SSL are highly variable, and national or population-based estimates are not available. Patient-, provider-, and procedure-level factors associated with the detection rates of SSL have not been well described. The aim of our study was to study the detection rates of SSL, variability of rates over time, and factors associated with detection rates of SSL in a national sample of patients undergoing colonoscopy using the GIQuIC registry.

METHODS:
We used colonoscopies submitted to the GIQuIC registry from 2014 to 2017 on adults, aged 18–89 years. Only the first colonoscopy record per patient was included. Indications for colonoscopy were categorized as screening, diagnostic, and surveillance. We used the hierarchical logistic models to study the factors associated with the detection rates of SSL. The Cochrane-Armitage test was used to study the significance of trend over time.

RESULTS:
There were a total of 5,173,211 colonoscopies performed by 3,934 endoscopists during the study period. Among the 2,101,082 screening colonoscopies over the study period in adults older than or equal to 50 years that were complete to the cecum, the average detection rate per endoscopist for SSL was 6.43% (SD 5.18) and 6.25% standardized for the 2010 US population. There was a significant increase in the detection rates of SSLs from screening colonoscopies over the study period from 4.99% in 2014 to 7.09% in 2017 (P trend <0.001). Clinically significant factors associated with higher detection rates of SSL were longer withdrawal times (>11 minutes vs ≤6 minutes) (odds ratio [OR] 9.61; 9.03–10.24), adequate preparation (OR 1.25; 1.22–1.28), female sex (OR 1.17; 1.16–1.18), and use of a specialized gastrointestinal pathology group (OR 1.12; 95% confidence interval 1.04, 1.19).

DISCUSSION:
Population-based estimates of the detection rates of SSL are 6% and have increased over time.
Gastric Necrosis because of Ingestion of Calcium Chloride
Authors: Nakagawa Yoichi , Maeda Atsuyuki , Takahashi Takamasa , Kaneoka Yuji 
Published: August 2020

ABSTRACT
Calcium chloride is a relatively harmless chemical that is frequently used as a dehumidifying agent. However, there have been rare reports that the accidental ingestion of this substance can cause gastric necrosis. We describe such a case of gastric necrosis in a 66-year-old woman who had accidentally ingested calcium chloride. Our findings indicate that the gastric necrosis in this patient was probably attributable to heat generated by the calcium chloride solution in the stomach. When ingested in large amounts, calcium chloride thus has the potential to cause gastric necrosis.
ENUNCIADOS COLOQUIALES O SIMBÓLICOS EN LA RESOLUCIÓN DE PROBLEMAS DE ESTADÍSTICA APLICADOS A SALUD
Authors: Walz María Florencia , Contini Liliana Ester , Ávila Olga Beatriz 
Published: August 2020

El lenguaje simbólico implica relacionar realidades y conceptos con un símbolo. Comprenderlo en el contexto de una ciencia implica realizar relaciones dialécticas entre el lenguaje de signos, las situaciones problemas y el concepto científico que subyace detrás de cada símbolo. En la asignatura Estadística de carreras orientadas a la salud, el empleo de signos, en general, tiene como objeto mostrar una intención para llevar a cabo una acción y no el de representar un objeto estadístico per sé.
El objetivo es evaluar si la resolución correcta de un ejercicio de distribución de probabilidad binomial, se da en igual medida según las consignas estén enunciadas en forma simbólica o de manera coloquial.
Con tal fin, en los exámenes finales y parciales de Estadística de la Licenciatura en Nutrición de la Facultad de Bioquímica y Ciencias Biológicas, se incorporó un problema de distribución binomial contextualizado con consignas expresadas simbólicamente y coloquialmente.
Se observó que no se da en igual medida la resolución correcta del ejercicio; resultando mejor cuando se va desde lo simbólico a lo textual/coloquial que a la inversa; evidenciándose también que el lenguaje simbólico facilita una resolución mecanicista que puede prescindir de la comprensión significativa del tema.
LICENCIATURA EN ADMINISTRACIÓN DE LA SALUD: UN ESTUDIO DE SUS GRADUADOS EN EL PERÍODO 2010-2018.
Authors: Bonomo Emanuel , Paulini Rosario , Dezar Gimena 
Published: August 2020

En el año 1992 se crea la carrera de grado de Licenciatura en Administración de Salud de la Escuela Superior de Sanidad (ESS) “Dr. Ramón Carrillo” dependiente de la Facultad de Bioquímica y Ciencias Biológicas (FBCB) de la Universidad Nacional del Litoral (UNL).
La presente investigación tiene como objetivo describir el perfil, lugar de procedencia y la duración de los estudios de los graduados de la Licenciatura en Administración de Salud de la ESS, y la valoración de los mismos sobre su formación de grado recibida. Se realizó una investigación cuanti–cualitativa, de corte transversal y descriptiva. La población de estudio estuvo constituida por 68 profesionales graduados de la carrera Licenciatura en Administración de la Salud de la ESS, FBCB-UNL, en el período 2010-2018. Se realizó un cuestionario a través de formularios de Google Drive, con modalidad para contestar on-line e individual. Entre los principales resultados del estudio, respecto al perfil de los graduados, se destaca que existe un predominio del género femenino (82,3%), y provienen del interior de la provincia de Santa Fe. En cuanto a la valoración sobre la formación de grado recibida, la misma fue positiva en su gran mayoría (87,1%). Además, un importante porcentaje de los graduados continuó formándose luego de finalizar sus estudios de grado (67,7%) y se sienten orgullosos de ser graduados de esta casa de estudios.
Se considera de suma importancia continuar con líneas de investigación sobre estudios de seguimiento de egresados para poder contar con datos relevantes y actualizados acerca de la realidad formativa y ocupacional de los mismos.
PROMOVIENDO LA INCLUSIÓN EDUCATIVA A TRAVÉS DE LA EDUCACIÓN ALIMENTARIA NUTRICIONAL
Authors: Paravano María Antonella , Dezar Gimena Valeria , Ortigoza Liliana 
Published: August 2020

La Educación Alimentaria Nutricional (EAN) y su influencia en la salud aportan contenidos y competencias a trabajar en la escuela, con el objetivo de mejorar la conducta alimentaria y elevar la calidad de vida. Cuando se combina la EAN y la alimentación escolar, puede mejorar directamente la salud y la nutrición de los estudiantes, al tiempo que les ayuda a desarrollar buenos hábitos alimenticios.
Lo mencionado anteriormente puede aplicarse en todas las fases de la vida, teniendo especial importancia en la niñez, adolescencia y en jóvenes-adultos. Promover conductas alimentarias favorables para la salud y un estilo de vida saludable es primordial para conseguir una mejor calidad de vida.
El presente trabajo relata la experiencia realizada en una Escuela de Enseñanza Media para Adultos de la ciudad de Santa Fe, con 100 alumnos que participaron voluntariamente y se encontraban cursando el tercer y quinto año, durante el año 2016. Se realizó un estudio de tipo transversal, descriptivo e interpretativo. Se diseñaron e implementaron talleres lúdico-didácticos, durante tres semanas consecutivas. Posteriormente, se aplicó una encuesta de opinión a los participantes de los talleres con el fin de valorar los mismos.
Los alumnos participaron de manera activa en cada uno de los encuentros, hubo gran de interés y motivación. Mediante el uso de estrategias lúdico-didácticas e innovadoras, fue posible fomentar hábitos saludables, impactando positivamente en el grado de conocimiento sobre un estilo de vida saludable de esta población.
Investigating Awareness and usage of Electronic Resources by Research Scientists in Ghana
Authors: Donkor Acheampong Lawrencia , Mingle Naa Aku , Osei-Kofi Paul Smart , Bekoe Stephen Kofi 
Published: August 2020

The study investigated the use of electronic resources/information by research scientists in Ghana. Specifically, to investigate the awareness and level of use of electronic resources; perceived reliance, benefits and impact of use of electronic resources on the research activities. The research design for the study was a survey. Questionnaire schedule was used to collect data from 103 scientists from selected institutes at the Council for Scientific and Industrial Research (CSIR), Ghana. The result revealed that majority of the scientists (92 %) used electronic resources. The most used type of resources were Electronic databases, electronic research reports and electronic journals. The purpose of use was mostly for research work (71 %). However only 34 per cent had had training in information literacy skills. Some of the impediments to accessing the electronic resources were poor ICT infrastructure (38 %) and lack of skills in accessing the resources (35 %). Generally, the use of electronic resources have improved research activities of research scientists It is recommended that continuous training (formal and informal) should be organised for research scientists to keep them abreast with new electronic applications and tools that will promote their level of competence and improvement in their research outputs. In Addition, ICT infrastructure should be improved in the various institutes for easy access to the electronic resources
Frontline Publishers of Punjabi Language Books
Authors: Chander Harish , Singh KP 
Published: August 2020

Publishing industry plays a vital role to spread knowledge. In modern days many local publishers are making knowledge available to the society through their native languages. Punjabi is one of the most popular languages of North Indian states. Many publishers from Punjab, Chandigarh, and Delhi are publishing books in Punjabi. The present study is attempted to provide the overview and analyse the growth and contribution of publishing books in Punjabi by various types of publishers for the decade 2004-2013. The study presents different categories of publishers with the number of books, major publishers of Punjabi books, the contribution of literary, government and academic institutions as publishers and geographical distribution of Punjabi books from Northern parts of India. The study reveals that most of the books have been published in Punjabi by commercial publishers. Punjab is the leading region to publish maximum books in Punjabi as compared to other states and ‘Lokgeet Prakashan’ is the top publisher among them all. This is the first study assessing book publishers of Punjabi books and a useful source of information for practitioners and academics interested in Punjabi language publications.
Effects of a 14-Day High-Intensity Shock Microcycle in High-Level Ice Hockey Players' Fitness
Authors: Brocherie Franck , Perez Jérôme , Guilhem Gaël 
Published: August 2020

Abstract
Brocherie, F, Perez, J, and Guilhem, G. Effects of a 14-day high-intensity shock microcycle in high-level ice hockey players' fitness. J Strength Cond Res 36(8): 2247–2252, 2022—Elite athletes face congested schedules with increased competition frequency and restricted time for training periods. Therefore, time is lacking to design long-term sport-specific block periodization. This study aimed to investigate the effects of adding a 14-day off-ice high-intensity training (HIT) shock microcycle to the usual training content of the pre-season preparation of high-level male ice hockey players' fitness. Fourteen players were randomly assigned to off-ice HIT (n = 7) or usual pre-season training (control, n = 7). For the HIT group, additional off-ice training content included 2 sessions of repeated-maximal resistance training, 2 sessions of repeated-sprint training, and 2 sessions of high-intensity intermittent training. Control group performed equal number of off-ice sessions using traditional strength and conditioning training. Off-ice Yo-Yo intermittent recovery test level 2 (YYIR2) and on-ice repeated-sprint ability test (RSA) were conducted before (pre-test) and 3 days after the intervention (post-test). Statistical significance was set at p < 0.05. Significant group × time interactions were found for off-ice YYIR2 performance (p < 0.05) and on-ice RSA-cumulated skating time (RSATT; p < 0.05). Compared with pre-test, off-ice YYIR2 distance covered significantly increased (from 708.6 ± 97.2 to 885.7 ± 118.7 m, p < 0.01; +25.8 ± 16.9%, p < 0.05) and on-ice RSATT significantly decreased (from 28.35 ± 0.87 to 28.14 ± 0.84 seconds; −1.7 ± 2.1%, both p < 0.05)] for HIT group. No significant pre-test to post-test changes were found for the control group (+2.7 ± 20.0% for YYIR2 and +0.9 ± 2.2% for RSATT). The implementation of a 14-day shock microcycle (including 6 HIT sessions) significantly improved fitness performance in high-level male ice hockey players. Such HIT block periodization offers a promising way to deal with congested schedules.
Occult metastatic thyroid cancer diagnosed during breast cancer axillary sentinel node biopsy
Authors: Herle Pratima , Boyages Steven , Hui Rina , Nahar Najmun , Ngui Nicholas K 
Published: August 2020

Summary
In most developed countries, breast carcinoma is the most common malignancy in women and while thyroid cancer is less common, its incidence is almost three to five times greater in women than in men. Since 1966, studies have demonstrated an association between thyroid and breast cancer and despite these studies, the mechanism/s by which they are related, remains unclear. We present a case of a 56-year-old lady who initially presented in 2014 with a screen detected left breast carcinoma but was subsequently found to have occult metastatic thyroid cancer to the axilla, diagnosed from a sentinel node biopsy from the primary breast procedure. The patient underwent a left mastectomy, left axillary dissection and total thyroidectomy followed by three courses of radioactive iodine ablation. Despite this, her thyroglobulin level continued to increase, which was secondary to a metastatic thyroid cancer parasternal metastasis. Breast and thyroid cancer presents metachronously or synchronously more often than by chance. With improving mortality in primary cancers, such as breast and differentiated thyroid cancer, it is likely that as clinicians, we will continue to encounter this association in practice.

Learning points:

There has been a long-standing observation of an association between breast and thyroid cancer although the exact mechanism of this association remains unclear.

Our patient presented with thyroid cancer with an incidental diagnosis from a sentinel node biopsy during her primary breast operation for breast cancer and was also found to have a parasternal distant bony metastasis.

Thyroid axillary metastases are generally rare.

The interesting nature in which this patient’s metastatic thyroid carcinoma behaved more like a breast carcinoma highlights a correlation between these two cancers.

With improving mortality in these primary cancers, clinicians are likely to encounter this association in clinical practice.

Systemic therapy for metastatic breast and thyroid cancers differ and therefore a clear diagnosis of metastasis is crucial.
Identification of Essential Genes and Fluconazole Susceptibility Genes inCandida glabrataby ProfilingHermesTransposon Insertions
Authors: Gale Andrew N , Sakhawala Rima M , Levitan Anton , Sharan Roded , Berman Judith , Timp Winston , Cunningham Kyle W 
Published: August 2020

AbstractWithin the budding yeasts, the opportunistic pathogen Candida glabrata and other members of the Nakaseomyces clade have developed virulence traits independently from C. albicans and C. auris. To begin exploring the genetic basis of C. glabrata virulence and its innate resistance to antifungals, we launched the Hermes transposon from a plasmid and sequenced more than 500,000 different semi-random insertions throughout the genome. With machine learning, we identified 1278 protein-encoding genes (25% of total) that could not tolerate transposon insertions and are likely essential for C. glabrata fitness in vitro. Interestingly, genes involved in mRNA splicing were less likely to be essential in C. glabrata than their orthologs in S. cerevisiae, whereas the opposite is true for genes involved in kinetochore function and chromosome segregation. When a pool of insertion mutants was challenged with the first-line antifungal fluconazole, insertions in several known resistance genes (e.g., PDR1, CDR1, PDR16, PDR17, UPC2A, DAP1, STV1) and 15 additional genes (including KGD1, KGD2, YHR045W) became hypersensitive to fluconazole. Insertions in 200 other genes conferred significant resistance to fluconazole, two-thirds of which function in mitochondria and likely down-regulate Pdr1 expression or function. Knockout mutants of KGD2 and IDH2, which consume and generate alpha-ketoglutarate in mitochondria, exhibited increased and decreased resistance to fluconazole through a process that depended on Pdr1. These findings establish the utility of transposon insertion profiling in forward genetic investigations of this important pathogen of humans.
Реакція радіального приросту Quercus robur L. на зміни клімату в Поліссі та Лісостепу
Authors: Koval Iryna 
Published: August 2020

Досліджено стиглі та перестиглі дубові насадження в Поліссі та Лісостепу, які ростуть в умовах свіжого сугруду та свіжого груду. Встановлено кліматичні чинники, які впливають на радіальний приріст дуба звичайного (Quercus robur L.) в Поліссі та Лісостепу і порівняно його реакції на зміни клімату в обох природних зонах. Виявлено реперні роки максимального (1891, 1902, 1924, 1931, 1957,1971, 1987) та мінімального (1895, 1906, 1918, 1922, 1929, 1936, 1950, 1976, 1992, 2000, 2005) радіального приросту дуба звичайного для Полісся, а також позитивні (1971, 1978, 1987) та негативні (1918, 1922, 1929, 1936, 1950, 1976, 1992, 2000, 2005 реперні роки для Лісостепу. Негативні реперні роки характеризуються дефіцитом опадів, посухами вегетаційного періоду, холодними або занадто теплими зимовими та ранньовесняними періодами, а позитивні –. сприятливим для росту дерев співвідношенням тепла і вологи.
Для першого періоду (1960-1988 рр.) виявлено позитивний вплив зимових та ранньовесняних температур на радіальний приріст дуба у Поліссі і Лісостепу. У другому періоді (1989-2013 рр.) відбувся протилежний сценарій – значне підвищення зимових та ранньовесняних температур призвело до зменшення радіального приросту. У другому періоді дубові насадження в Поліссі більше потерпали від теплих зим, ніж насадження в Лісостепу. Негативний вплив посух вегетаційного періоду на приріст посилився у другому періоді для обох насаджень. Упродовж другого періоду опади суттєво втратили позитивний вплив на приріст у насадженнях як Полісся, так і Лісостепу.
Підтверджено гіпотезу щодо посилення чутливості реакції радіального приросту дуба звичайного до змін клімату в Поліссі та Лісостепу.
Особливості техногенного впливу лісокористування на чистоту води у гірських лісових водотоках
Authors: Korzhov Volodymyr , Kudra Vasyl 
Published: August 2020

Під час здійснення лісозаготівель у гірських умовах із застосуванням наземного транспортування деревини відбувається трансформація лісового ґрунту як у межах лісосіки, так і на трелювальних волоках. Трелювальні волоки, по яких заготовлена деревини доставляється до навантажувальних майданчиків, прокладаються на схилах різної стрімкості, що спричиняє порушення монолітної структури ґрунту та утворення значних обсягів експлуатаційної ерозії. Внаслідок багаторазового проїзду лісових машин по волоках формуються глибокі колії, по яких відбувається поверхневий стік води до підніжжя схилу, яка потрапляє у водотоки. Тому волоки одночасно є і руслами стоку води, яка концентрується на них у разі виникнення інтенсивних опадів та внаслідок cніготанення. При цьому разом із водою виносяться і частинки лісового ґрунту, що призводить до забруднення води.
Дослідженнями зарубіжних і вітчизняних науковців встановлено, що основним потенційним впливом на чистоту води внаслідок лісогосподарської діяльності є потрапляння у річки частинок землі з доріг і трелювальних волоків. Тому одним із важливих завдань є встановлення ступеня впливу техногенних чинників, які виникають під час лісокористування, на ступінь забруднення води в лісових водотоках. З огляду на це, були здійснені чотирирічні дослідження на двох лісових водозборах з метою вивчення ступеня каламутності води в руслах рік. У результаті дослідження встановлено чітку тенденцію щодо збільшення каламутності води в робочі дні (понеділок-п’ятниця) та її суттєве зменшення під час не робочих днів (субота, неділя). При цьому характерним є зростання забруднення води, починаючи з вранішніх годин з поступовим його зменшенням наприкінці робочого дня.
INACTIVITY AT NIGHT: A CASE STUDY OF THE NOCTURNAL BEHAVIORS OF TWO CAPTIVE Panthera onca (FELIDAE) SPECIMENS
Authors: Boccacino Débora , Maia Caroline Marques , Dos Santos Eliana Ferraz , Santori Ricardo Tadeu 
Published: August 2020

Inactivity is a common daytime behavior expressed by wild cats in zoos. It is not clear whether this inactivity is due to the constraints of the captive environment or is a result of a more natural behavior by these animals. Therefore, this work evaluated the behavior of two Panthera oncacaptive specimens, including their inactivity, during the evening/night period. The jaguars were filmed individually in different days, starting at 5:30 pm and finishing between 7:00 pm and 1:30 am, including non-feeding and feeding days. Regardless of whether they were fed or not, both jaguars expressed a significant rate of inactivity. In addition, when fed, one of the jaguars increased its movements and active behaviors, although its inactivity remained high, while the other jaguar further reduced the expression of such behaviors. Therefore, this work concludes that these jaguars were just as inactive during the evening/night period as they were during daytime. Excessive inactivity might be regarded as a negative behavior; with its highest expression being an effect of the captive environment, which might compromise the welfare of the assessed jaguars and possibly of other wild cats. In addition, since the behavioral expression varied between the studied jaguars, depending on the feeding or non-feeding status, we recommend that futures studies should taking into account the individual variations, especially when there are differences in age, health, and management conditions between the specimens.