bluuebunny/crossref_metadata_2025_split huggingface dataset:
Known-Groups and Convergent Validity of the Telephone Rey Auditory Verbal Learning Test total Learning Scores for Distinguishing Between Older Adults With Amnestic Cognitive Impairment and Subjective Cognitive Decline
Authors: Jagtap Shreya , Dawson Deirdre R , Vandermorris Susan , Anderson Nicole D , Davids-Brumer Naomi , Dar Mishal , Bernick Alana , Rotenberg Shlomit 
Published: September 2020

Abstract

Objective
To examine known-groups validity of a telephone administration of the total learning scores of the Rey Auditory Verbal Learning Test (RAVLT) in discriminating between people with subjective cognitive decline (SCD) and amnestic mild cognitive impairment (aMCI) and convergent validity of the telephone-RAVLT.

Method
In total, 83 older adults (age = 71.4 ± 7.0) with SCD or aMCI completed the RAVLT learning trials over the telephone and the Hopkins Verbal Learning Test (HVLT) in-person.

Results
Telephone-RAVLT total recall significantly correlated with HVLT total recall (r = .49, p &lt; .001). Significant between group differences were found (effect size = 0.94).

Conclusions
This study provides support for known-groups and convergent validity of the telephone-RAVLT.
Nearby Neighbourhood Influences on Adolescent Offending
Authors: Vogel Matt , Hoeben Evelien M , Bernasco Wim 
Published: September 2020

Abstract
This study extends recent research on the spatial dynamics of neighbourhood disadvantage and youth offending. Data include self-reported offences from 794 Dutch adolescents and the socio-economic status in their residential neighbourhood and the surrounding community. The findings reveal that youth engage in the highest levels of offending when they reside in disadvantaged neighbourhoods surrounded by neighbourhoods characterized by relative affluence. This spatial pattern is attributable to greater temptations to offend, reduced parental monitoring, and more frequent involvement in unstructured activities among youths who live in close proximity to neighbourhoods more affluent than their own. This study highlights the importance of criminogenic opportunities and parental monitoring for understanding the spatial dynamics of neighbourhood disadvantage on offending.
Impaired Fertility in Women With Inflammatory Bowel Disease: A National Cohort Study From Sweden
Authors: Druvefors Emma , Landerholm Kalle , Hammar Ulf , Myrelid Pär , Andersson Roland E 
Published: September 2020

Abstract

Background and Aims
Inflammatory bowel disease [IBD] has been associated with reduced female fertility. We analyse fertility in a national cohort of women with IBD.

Methods
Fertility was assessed in women with IBD aged 15–44 years in 1964–2014, identified from the Swedish National Patient Register and a matched cohort [ratio 1:5]. Patients with indeterminate colitis or inconsistent IBD coding were classified as IBD-unclassified [IBD-U].

Results
The cohorts included 27 331 women with IBD and 131 892 matched individuals. The fertility rate in IBD was 1.52 (standard deviation [SD] 1.22) births per 1000 person-years and 1.62 [SD 1.28] [p &lt;0.001] in matched individuals. Fertility was impaired in all IBD subtypes compared with the matched cohort (hazard ratio Crohn’s disease [CD] 0.88, 95% confidence interval [CI] 0.85–0.91; IBD-U 0.86, 95% CI 0.83–0.89; and ulcerative colitis [UC] 0.96, 95% CI 0.93–0.98). Fertility improved during the study period for the IBD cohort except for CD. Parity progression ratio, the proportion of IBD women progressing from one parity to the next compared with the matched cohort, was decreased at all parity levels for CD and IBD-U, but only for multiparous women in UC. Contraceptive usage was higher in IBD, both before and after the diagnosis. Disease severity, bowel resections, and perianal disease in CD affected fertility negatively.

Conclusions
Fertility was impaired mainly in women with CD and IBD-U, and less so in UC. During the study period, fertility improved in women with UC or IBD-U. Some results suggest a role of voluntarily reduced fertility.
A New League of Extraordinary Gentlemen? The Professionalization of International Law Scholarship in the Netherlands, 1919–1940
Authors: de Waele Henri 
Published: September 2020

Abstract
Despite the historical turn in the study of public international law and the advance of comparative approaches, still too little attention is paid nowadays to specific national traditions. This holds, inter alia, for the scholarly views and practices in the Netherlands during the first half of the 20th century. This article seeks to shed light on the experiences here at the advent of the League of Nations and its tentative ‘new world order’. Offering a meso-level analysis, it portrays the leading protagonists during the 1920s and 1930s, aiming to provide a snapshot of how their discipline and activities underwent an unexpectedly swift professionalization. This process is perceived to have run along three distinct vectors – academic, societal and diplomatic/bureaucratic – which are each examined in turn. Novel opportunities stemming from the rise of the international judiciary, especially the two Permanent Courts established on Dutch soil, are looked at separately. The research delivers a greater insight into the inter-war era and the challenges faced by (academics from) smaller nations, enabling us to situate underexplored local experiences within a global frame, and offering useful lessons for (the writing of) international law history more generally.
Microbial adaptation in vertical soil profiles contaminated by an antimony smelting plant
Authors: Xu Rui , Sun Xiaoxu , Lin Hanzhi , Han Feng , Xiao Enzong , Li Baoqin , Qiu Lang , Song Benru , Yang Zhaohui , Sun Weimin 
Published: September 2020

ABSTRACT
Antimony mining has resulted in considerable pollution to the soil environment. Although studies on antinomy contamination have been conducted, its effects on vertical soil profiles and depth-resolved microbial communities remain unknown. The current study selected three vertical soil profiles (0–2 m) from the world's largest antimony mining area to characterize the depth-resolved soil microbiota and investigate the effects of mining contamination on microbial adaptation. Results demonstrated that contaminated soil profiles showed distinct depth-resolved effects when compared to uncontaminated soil profiles. As soil depth increased, the concentrations of antimony and arsenic gradually declined in the contaminated soil profiles. Acidobacteria, Chloroflexi, Proteobacteria and Thaumarchaeota were the most variable phyla from surface to deep soil. The co-occurrence networks were loosely connected in surface soil, but obviously recovered and were well-connected in deep soil. The metagenomic results indicated that microbial metabolic potential also changed with soil depth. Genes encoding C metabolism pathways were negatively correlated with antimony and arsenic concentrations. Abundances of arsenic-related genes were enriched by severe contamination, but reduced with soil depth. Overall, soil depth-resolved characteristics are often many meters deep and such effects affected the indigenous microbial communities, as well as their metabolic potential due to different contaminants along vertical depths.
Tea polyphenol EGCG inhibited colorectal-cancer-cell proliferation and migration via downregulation of STAT3
Authors: Luo Ke-Wang , Xia Jun , Cheng Bao-Hui , Gao Han-Chao , Fu Li-Wu , Luo Xin-Le 
Published: September 2020

Abstract

Background
Green tea is a popular beverage worldwide and epigallocatechin-3-gallate (EGCG) is the most bioactive polyphenol in green tea. Our study aims to investigate the anti-proliferation and anti-migration effects of EGCG against colorectal-cancer SW480, SW620, and LS411N cells, and elucidate the underlying mechanism.

Methods
The in vitro anti-proliferation and anti-migration effects of EGCG against colon-cancer cells were evaluated using MTT, scratch-wound-healing, and transwell-migration assays. The effects of EGCG on apoptosis were assessed by Annexin V-FITC/PI double staining and JC-1 staining. Besides, Western blotting was employed to detect the protein-expression level and elucidate the underlying pathways. Real-time qPCR and dual-luciferase reporter assay were adopted to determine the mRNA level and promoter activity.

Results
Our results demonstrated that treatment with EGCG resulted in significant inhibition of cell proliferation by the induction of apoptosis. EGCG also inhibited SW480 cell migration in a dose-dependent manner as assessed by wound-healing and transwell-migration assays. Western blot confirmed that EGCG induced apoptosis by the activation of Caspase-3 and PARP. In addition, both STAT3 and phosphorylated STAT3 (p-STAT3) were downregulated significantly by EGCG in three selected colorectal-cancer cell lines. EGCG treatment also resulted in a significant decrease in Bcl-2, MCL-1, and Vimentin, and an increase in E-cadherin. When STAT3 was inhibited, EGCG showed no obvious effect on cell proliferation and migration. Further investigation by luciferase-reporter-activity assay showed that EGCG suppressed the promoter activity of STAT3 and downregulated the transcription of STAT3.

Conclusion
Our study presents evidence on the anti-proliferation and anti-migration effects of EGCG against colorectal-cancer SW480, SW620, and LS411N cells by downregulating the expression of STAT3 and suggests that EGCG could be an effective and natural supplement for colon-cancer treatment.
Comprehensive Transcriptome of the Maize Stalk Borer,Busseola fusca, from Multiple Tissue Types, Developmental Stages, and Parasitoid Wasp Exposures
Authors:   The Busseola fusca Genome Consortium
Published: September 2020

AbstractBusseola fusca (Fuller) (Lepidoptera: Noctuidae), the maize stalk borer, is a widespread crop pest in sub-Saharan Africa that has been the focus of biological research and intensive management strategies. Here, we present a comprehensive annotated transcriptome of B. fusca (originally collected in the Western Province of Kenya) based on ten pooled libraries including a wide array of developmental stages, tissue types, and exposures to parasitoid wasps. Parasitoid wasps have been used as a form of biocontrol to try and reduce crop losses with variable success, in part due to differential infectivities and immune responses among wasps and hosts. We identified a number of loci of interest for pest management, including genes potentially involved in chemoreception, immunity, and response to insecticides. The comprehensive sampling design used expands our current understanding of the transcriptome of this species and deepens the list of potential target genes for future crop loss mitigation, in addition to highlighting candidate loci for differential expression and functional genetic analyses in this important pest species.
No SARS-CoV-2 Neutralization by Intravenous Immunoglobulins Produced From Plasma Collected Before the 2020 Pandemic
Authors: Schwaiger Julia , Karbiener Michael , Aberham Claudia , Farcet Maria R , Kreil Thomas R 
Published: September 2020

Abstract
The 2020 SARS-CoV-2 pandemic is caused by a zoonotic coronavirus transmitted to humans, similar to earlier events. Whether the other, seasonally circulating coronaviruses induce cross-reactive, potentially even cross-neutralizing, antibodies to the new species in humans is unclear. The question is particularly relevant for people with immune deficiencies, as their health depends on treatment with immunoglobulin preparations that need to contain neutralizing antibodies against the pathogens in their environment. Testing 54 intravenous immunoglobulin preparations, produced from plasma collected in Europe and the United States, confirmed highly potent neutralization of a seasonal coronavirus; however, no cross-neutralization of the new SARS-CoV-2 was seen.
Comparison of in situ techniques to evaluate the recovery of indigestible components and the accuracy of digestibility estimates
Authors: Adams Jordan M , Norris Aaron B , Dias Batista Luiz F , Rivera Madeline E , Tedeschi Luis O 
Published: September 2020

Abstract
Indigestible components, including indigestible dry matter (iDM) and indigestible neutral detergent fiber (iNDF), play an integral role as internal markers for determining ruminal kinetics and digestibility estimations. However, the accuracy of internal markers is dependent upon the incubation technique utilized as bag type (BT) and incubation length (IL) can be significant sources of error. Previous studies have primarily focused on iDM and iNDF as digestibility markers, but few studies have compared digestibility estimates to those of acid detergent insoluble ash (ADIA). Therefore, our objective was to investigate the effect of BT (F57, F58, and Dacron) and IL (288 and 576 h) on iDM and iNDF residues, DM and NDF digestibilities, and fecal recoveries when using in situ incubations. Additionally, we evaluated the accuracy of digestibility estimates when using iDM, iNDF, and ADIA. For iDM and iNDF, feed residues demonstrated a BT × IL interaction (P &lt; 0.01). However, fecal residues were only influenced by the main effects of BT and IL (P &lt; 0.01), with the F58 BT and 288-h IL having the greatest residues for both iDM and iNDF. The variation in residues was greatly reduced when using iNDF compared with iDM. Fecal recovery estimates most closely approximated 100% recovery when utilizing ADIA and iDM using the F57 × 576 h incubation method (P &lt; 0.01), although recovery was overestimated for all incubation combinations. Fecal NDF recovery estimates better represented the excretion profiles when the F57 × 576 h combination was used with iDM as the internal marker (P &lt; 0.01). Estimates of DM and NDF digestibility were the most accurate when utilizing ADIA (P &lt; 0.01) relative to all other treatments. Our results indicate that the proper methodological application is specific to the purpose of the inferences. When evaluating fecal recoveries and digestibility, ADIA or iDM with F57 at 576-h in situ incubation provides the greatest accuracy.
Comparative Mitochondrial Analysis of Cnaphalocrocis exigua (Lepidoptera: Crambidae) and Its Close Relative C. medinalis
Authors: Zhang Kai-Jun , Rong Xia , Lv Zhao-Peng , Liu Lei , Li Guo-Yang , Liu Huai 
Published: September 2020

Abstract
Rice leaffolders are important pests on rice in Asia, Oceania, and Africa, causing serious loss to rice production. There are two main rice leaffolders in China, namely Cnaphalocrocis medinalis (Guenée) and C. exigua (Butler) with the former having the ability of long-distance migration. To reveal the differences in the mitochondrial genomes (mitogenome) between them, we compared the completed mitogenome of C. exigua with three C. medinalis individuals. Although phylogenetic analysis based on the mitogenomic data strongly supported the close relationship between these two species, many differences were still being revealed. The results showed that the mitogenome of C. exigua was shorter in length (15,262 bp) and slight lower in AT content than that of C. medinalis. Except for the different start codons of nad3 and nad6 gene, we also found the cox1 gene had a typical start codon ‘ATG’ which suggested that the starting position of this gene must be reconsidered in the entire superfamily Pyraloidea. All tRNAs have a typical clover-leaf structure, except for the dihydrouridine (DHU) stem losing of trnS1, which has the atypical anticondon ‘TCT’ instead of ‘GCT’ in C. medinalis and most Pyraloidea species. Two intergenic regions (between trnY and cox1, nad3 and trnA) featured by AT repeats were only found in C. medinalis and even rarely appeared in reported Pyraloidea species. Furthermore, regardless of interspecific comparison or intraspecific comparison of these two species, protein coding genes, especially the atp8 genes, had quite different evolutionary rates.
The Granulate Cutworm (Lepidoptera: Noctuidae): Biological Parameters Under Controlled Conditions, Host Plants, and Distribution in the Americas
Authors: Specht Alexandre , Dias Fernando M S , San Blas Germán , Roque-Specht Vânia F , Casagrande Mirna M , Mielke Olaf H H , Montezano Débora G , Santos Izailda Barbosa , Paula-Moraes Silvana V , Hunt Thomas E , Malaquias Juaci V , Bonfin Felipe A D , Vieira Paulo V M 
Published: September 2020

AbstractFeltia subterranea (Fabricius), commonly known as the granulate cutworm, is a common species of owlet moths (Noctuidae) of major agricultural importance, widely distributed in Nearctic and Neotropical regions. This study was conducted to determine the species biological parameters, gather information about its larval host plants, and assess the agricultural significance of this species in the Americas. The viability of the egg, larval, pupal stages, and prepupal period was 98, 98, and 100%, respectively, under laboratory conditions. The average duration of the egg, larval, pupal stages, and prepupal period was 3, 17, 4, and 13 d, respectively. All laboratory-reared larvae developed through five instars. The growth ratio was 1.93 for females and 1.85 for males. The duration of the larval stage was significantly longer in females than in males from the fourth instar. The duration of the pupal stage was significantly shorter in females than in males. When larval and pupal stage durations were combined, there were no significant differences in total development time as a function of sex. In total, 159 botanical taxa belonging to 41 families were recorded as host species for F. subterranea. The families with the greatest number of host species were Fabaceae (22), Poaceae (19), Asteraceae (16), Brassicaceae (13), Solanaceae (12), Amaranthaceae (7), Cucurbitaceae (7), and Malvaceae (5). It is noteworthy that the large number of native weeds used by F. subterranea as host plants could represent a significant source of infestation of crops in the agricultural landscape.
Denoising of series electron holograms using tensor decomposition
Authors: Nomura Yuki , Yamamoto Kazuo , Anada Satoshi , Hirayama Tsukasa , Igaki Emiko , Saitoh Koh 
Published: September 2020

Abstract
In this study, a noise-reduction technique for series low-dose electron holograms using tensor decomposition is demonstrated through simulation. We treated an entire dataset of the series holograms with Poisson noise as a third-order tensor, which is a stack of 2D holograms. The third-order tensor, which is decomposed into a core tensor and three factor matrices, is approximated as a lower-rank tensor using only noise-free principal components. This technique is applied to simulated holograms by assuming a p-n junction in a semiconductor sample. The peak signal-to-noise ratios of the holograms and the reconstructed phase maps have been improved significantly using tensor decomposition. Moreover, the proposed method was applied to a more practical situation of time-resolved in situ electron holography by considering a nonuniform fringe contrast and fringe drift relative to the sample. The accuracy and precision of the reconstructed phase maps were quantitatively evaluated to demonstrate its effectiveness for in situ experiments and low-dose experiments on beam-sensitive materials.
Defibrotide for the Treatment of Pediatric Inflammatory Multisystem Syndrome Temporally Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in 2 Pediatric Patients
Authors: Lang Peter , Eichholz Thomas , Bakchoul Tamam , Streiter Monika , Petrasch Maurice , Bösmüller Hans , Klein Reinhild , Rabsteyn Armin , Lang Anne-Marie , Adams Constantin , Klingel Karin , Gessner Michaela , Rosenberger Peter , Ruef Peter , Handgretinger Rupert 
Published: September 2020

AbstractThe pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 infection is a severe complication of coronavirus disease 2019. Since impaired coagulation and thrombosis/endotheliitis are suspected pathomechanisms, we treated 2 patients with defibrotide, a profibrinolytic, antithrombotic, antiinflammatory oligonucleotide. Symptoms resolved during treatment. Moreover, coagulation parameters indicating hypofibrinolysis and complement activation normalized.The pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 infection is a severe complication of coronavirus disease 2019. Since impaired coagulation and thrombosis/endotheliitis are suspected pathomechanisms, 2 patients received defibrotide, a profibrinolytic, antithrombotic, antiinflammatory oligonucleotide. Symptoms resolved and hypofibrinolysis/complement activation normalized during treatment.
Job Retention Among Resettled Refugees in The US:The Importance of Context
Authors: Crea Thomas M , Tobin Emma , Young Ann-Elizabeth , Ko Christian , Weber Alexandra 
Published: September 2020

Abstract
The primary objective of the US refugee resettlement program is for beneficiaries to achieve economic self-sufficiency. Yet, little research has examined the extent to which this objective has been achieved, nor the programmatic and contextual variables that influence this outcome. This study examines how beneficiaries’ individual and job characteristics are associated with the likelihood of job retention after 90 days of employment. Data were obtained on 1787 refugees served by the International Institute of New England from March 2015 to January 2019. Logistic regression models were used to examine the predictors of retention in four cities (Boston, MA; Lowell, MA; Manchester, NH; and Nashua, NH). Different patterns emerged across cities, related to factors such as pay, educational level, legal immigration status, job permanency, and gender. The concept of self-sufficiency is closely linked to the context of resettlement and thus requires more careful articulation as a goal of the refugee resettlement program.
Addressing the Educational Needs of Street Children in Lebanon: A Hotchpotch of Policy and Practice
Authors: Al-Hroub Anies , Saab Cyrine , Vlaardingerbroek Barend 
Published: September 2020

AbstractThe presence of school-age children engaged in various subsistence activities on the street when they should be at school is a common and growing phenomenon worldwide. It has become a major social issue in Lebanon over the past decade fuelled by a massive increase in the refugee population. Robust statistical data on street children at the national level are, however, missing. Government ministries and NGOs have responded to varying degrees to address the needs of these children, but the overall picture is one of the piecemeal efforts with a poor level of inter-sectoral coordination. What is badly needed is an integrated approach to the problem that takes into account the unique Lebanese context.
Anal high-grade and late-stage cancer management in low-income setting: a case report
Authors: Colangelo Anna Claudia , Pizzol Damiano , Antunes Mario 
Published: September 2020

AbstractThe burden of cancer is increasing in sub-Saharan Africa due to ageing, common risk factors and population growth. Anal cancer is a human papillomavirus-related rare disease with an incidence rate of 1.8 per 100 000 persons overall with an increasing incidence of by 2% per year in the last three decades. Despite that gold standard management is well described, in low-income countries, there is no possibility for a proper management. We presented a late-stage anal cancer case that reflects the urgent necessity to create the adequate condition for the development of effective oncologic approach including prevention, diagnosis and management.