bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hemodynamic and Pharmacokinetic Interactions of TPN171 with Alcohol in Healthy Male Subjects
Authors: Cheng Jie , Qian Hongjie , Wang Yu , Liang Liyu , Xu Wenjing , Liu Ye , Chen Qian , Yu Chen , Duan Huaqing , Wang Zhen , Wang Hang , Jia Jingying 
Published: February 2025

ABSTRACTThis study aimed to evaluate the effects of the concomitant administration of TPN171 and alcohol on hemodynamic and pharmacokinetic characteristics in healthy Chinese male subjects. Fifteen eligible subjects were randomly assigned to one of three sequences, each comprising three treatments: Treatment A (placebo +0.5 g/kg alcohol), Treatment B (TPN171 + 0.5 g/kg alcohol), and Treatment C (TPN171 + placebo). Enrolled subjects were administered with 10 mg TPN171 and/or 0.5 g/kg alcohol in fasting state in a randomized crossover design. Blood pressure, pulse rate (PR), blood samples, and breath alcohol test were measured at designated time points for hemodynamic and pharmacokinetic analyses. Compared with 10 mg TPN171 alone, administration of 10 mg TPN171 + 0.5 g/kg alcohol significantly lowered the area under the effect–time curve from 0 to 4 h (AUEC0‐4h) of systolic blood pressure (95% confidence interval [CI]: −29.75 to −0.83, p = 0.039) and significantly increased AUEC0–4h of PR (95% CI: 7.47–28.92, p = 0.003). Compared with 0.5 g/kg alcohol alone, administration of 10 mg TPN171 + 0.5 g/kg alcohol contributed to significantly higher maximal increase of PR (95% CI: 2.78–9.44, p = 0.002) and AUEC0‐4h of PR (95% CI: 1.08–24.52, p = 0.035). Alcohol had no influence on the pharmacokinetics of TPN171, and vice versa. Though the concomitant administration of TPN171 and alcohol induced a more pronounced increase in PR, this did not result in clinical symptoms or heart rate increase‐related adverse events, indicating that the combined use was generally safe and well‐tolerated.
Potential of Mussel Habitat Enhancement to Alleviate Eutrophication in Nutrient‐Enriched Estuaries
Authors: Cottingham Alan , Bossie Andrew , Valesini Fiona , Maus Charles , Cronin‐O'Reilly Sorcha , Tweedley James R. , Galimany Eve 
Published: February 2025

ABSTRACTThrough altered freshwater flow regimes and excessive anthropogenic nutrient input, many estuaries around the world are showing signs of eutrophication. As shellfish can alleviate some of these issues through their water filtration capacity, shellfish habitat restoration efforts have increased markedly in the past decade. This study quantifies, for the first time, the water filtration capacity of the Black Pygmy Mussel Xenostrobus securis and the potential for habitat enhancement to alleviate eutrophication issues in a hypereutrophic estuary in south Western Australia. Substrate, comprising coir matting, was deployed by community volunteers in four‐panel arrangements in the rivers of the Swan‐Canning Estuary onto which X. securis recruited naturally. In the Swan River, average mussel densities were 3377 individuals m−2, based on 10% mat coverage. River water comprised relatively high particulate organic matter (POM) concentrations, particularly in spring (up to 9.2 mg L−1). Standardised clearance rates (CR; g−1 mussel tissue) were typically greater (> 5.0 L h−1) in summer when chlorophyll a concentrations, salinities and water temperature were elevated, whereas CR was often < 2.0 L h−1 in early spring. In the Swan River, it was estimated that for every square metre of habitat enhanced, 9.2 × 105 L of water could be potentially cleared during spring and 1.7 × 106 L over summer, the latter incorporating 5.3 kg of organic matter into mussel biomass. On a larger scale, 1000 m2 of deployed habitat over the course of summer has the potential to clear 24.5% of the volume of the tidal portion of the Swan River and 64.4% of the volume of the smaller Canning River. The results thus demonstrate the efficacy of using cost‐effective soft substrates deployed by community volunteers to enhance habitat for mussels and its potential to assist in alleviating eutrophication issues.
Associations of Inflammatory Markers With Neurological Dysfunction and Prognosis in Patients With Progressive Stroke
Authors: Wang Yingying , Zhang Zhouao , Hang Xiaoyu , Wang Wei 
Published: February 2025

ABSTRACTObjectiveThis study aimed to explore the associations between inflammatory markers and the severity of early neurological dysfunction and prognosis in patients with progressive stroke (PS) and evaluated the predictive value of inflammatory markers for PS.MethodsAmong 711 acute ischemic stroke (AIS) patients, 210 patients with PS and 501 patients without PS were included. Six inflammatory markers, including neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), systemic immune‐inflammation index (SII), systemic inflammatory response index (SIRI), and pan‐immune‐inflammation value (PIV), were measured and compared between two groups. Correlation analysis was used to analyze the correlation between inflammatory markers and early neurological dysfunction in patients with PS. Univariate and multivariate regression analyses were applied to screen the factors for the prognosis of PS patients. The receiver operating characteristic (ROC) curve was utilized to evaluate the predictive value for the prognosis of PS patients.ResultsElevated levels of NLR, LMR, SII, and PIV were observed in PS patients. Correlation analysis revealed positive correlations between NLR, PLR, SII, SIRI, PIV, and early neurological deficits, while LMR showed a negative correlation in PS patients. Multivariate analysis identified LMR and the National Institutes of Health Stroke Score (NIHSS) as independent risk factors for poor outcome of PS patients. The predictive value of LMR alone was limited (AUC = 0.59), but combining it with NIHSS improved predictive accuracy (AUC = 0.73) (p < 0.05).ConclusionThese findings suggest that inflammatory markers, particularly LMR, should be considered in PS management, and their combination with NIHSS enhances outcome prediction.
An Experimental Study on the Fatigue Response of Hybrid Additively Manufactured 1.2343 Hot Work Steel ‐ MARAGING Steel MS1
Authors: Croccolo Dario , Ćirić‐Kostić Snežana , De Agostinis Massimiliano , Fini Stefano , Mele Mattia , Bogojević Nebojša , Sinđelić Vladimir , Olmi Giorgio 
Published: February 2025

ABSTRACTHybrid additive manufacturing consists of upgrading wrought material by an additive process, adding stacked layers through the melting and sintering of a different material powder. A literature survey indicates that fatigue data for hybrid additively manufactured parts are currently missing. This paper is focused on the fatigue response of 1.2343 hot work steel, upgraded by a maraging steel MS1 powder processed by laser powder bed fusion, and finally heat‐treated complying with the specifications from the powder supplier. Results, supported by microscopy SEM analyses, indicate the fatigue response is significantly reduced if compared to that of plain additively manufactured MS1. This is due to the joint between the two materials acting as a weak point, where the porosity of MS1 is incremented with respect to specifications. Moreover, due to the unavailability of a heat treatment that is suitable for both the involved materials, the hot work steel side exhibits poor hardness.
Taking a Pause: Co‐Designing a Reflection Tool for Meaning Creation in Patients With Type 2 Diabetes
Authors: Kim Hyeryoung 
Published: February 2025

ABSTRACTObjectivesThis study aims to explore how the design of a self‐reflection tool can assist patients with type 2 diabetes (T2D) by facilitating and sustaining their reflective practices in the context of diabetes care. Specifically, the study seeks to examine how patients utilize self‐reflection tools, identify aspects they feel improve diabetes management, and uncover the opportunities and challenges they encounter when integrating such tools into their daily lives.MethodsThe research involved two phases: first, the preliminary development of a self‐reflection tool prototype and second, the exploration of user experience. During the second phase, five patients with T2D participated in three interview sessions bi‐weekly over the period of 6 weeks. The interviews were transcribed and thematically coded, and affinity diagramming was then used to synthesize the data.ResultsFour main themes emerged from the interviews. The designed self‐reflection tool was found to have the potential to enhance participants’ motivation for engaging in diabetes management by improving diabetes management, initiating self‐reflection, facilitating new thoughts and meanings, and providing opportunities for the patients to share their reflections.ConclusionsThe designed self‐reflection tool helped patients with T2D by encouraging them to adopt a more positive mindset and supporting them in addressing challenges related to their diabetes management. The study suggests that there is promising potential for the self‐reflection tool to evolve into a reflection‐sharing tool that can be shared with other patients.Patient or Public ContributionParticipants with T2D took part in the designed interviews, and their experiences and comments meaningfully contributed to enriching the co‐design of the self‐reflection tool. The suggested potential for this tool to be expanded into a reflection‐sharing tool is also significant.
Migration diplomacy and Greek–Turkish relations: A three‐level game analysis
Authors: Tsourapas Gerasimos 
Published: February 2025

AbstractMigration diplomacy has become a critical element of contemporary geopolitics, yet its complex dimensions remain underexplored. This article introduces a novel three‐level game framework to examine how foreign policy strategies leverage cross‐border mobility across domestic, bilateral and supranational dimensions. The 2020 Greek–Turkish border crisis serves as a case study to investigate how domestic political imperatives, bilateral disputes and engagement with European institutions shaped the two government' strategies. The study integrates process tracing with diverse multi‐source data – including policy documents, media analysis and stakeholder interviews – to demonstrate how migration crises function as instruments of geopolitical contestation. This framework is also applied to cases, such as Morocco–Spain, Tunisia–EU and Belarus–EU, advancing theoretical and empirical understandings of migration diplomacy. The article provides fresh insights into the interplay between domestic politics, bilateral relations and supranational governance, illustrating how migration diplomacy is both a reflection and a driver of contemporary power dynamics in global geopolitics.
Monitoring the Sustainability of a Breastfeeding Guideline During the COVID‐19 Pandemic: A Mixed‐Methods Study
Authors: Harillo‐Acevedo David , Molina‐Rodríguez Alonso , Ramos‐Morcillo Antonio Jesús , Suárez‐Cortes María , Ruzafa‐Martínez María 
Published: February 2025

ABSTRACTAimTo analyse the impact of the COVID‐19 pandemic on the sustainability of a breastfeeding (BF) clinical practice guideline (CPG) for women without COVID‐19, throughout the 5 waves of the pandemic.DesingA mixed‐methods design was utilised.MethodsFor the quantitative approach, an interrupted time series design was utilised, as well as the analysis of CPG sustainability reports as a qualitative approach. The study setting was in a health area in the Spanish health system from April 2019, until October 2021. The sample was composed of 2239 mother–infant dyads.ResultsThe exclusive‐BF rate at hospital discharge obtained values between 90% and 94.8%, without statistically significant changes. A significant increase in the risk of not starting BF in the first feeding was observed (adjusted odds ratio = 9.36; 95% CI: 1.04–84.13), between the pre‐pandemic period and the first wave. Skin‐to‐skin contact (SSC) decreased in the first wave to 82.20%, and the oscillations observed throughout the pandemic were not statistically significant. In general, the qualitative indicators were maintained. A decrease was observed in the spaces used for postpartum care due to the re‐assigning to the intensive care unit. Also, the acquisition of materials and equipment decreased.ConclusionsThe measures implemented for the sustainability of the BF CPG during the 5 waves of the pandemic were positive. The programmes of implementation of BF guidelines were shown to resist the COVID‐19 pandemic.ImpactOur findings contribute to the understanding and evolution of the main indicators of the sustainability of a BF CPG on COVID‐19 context, providing details on the magnitude of the effect and the process of change.Reporting MethodThe Preferred Reporting Items for observational studies (STROBE) checklist was followed.Patient or Public ContributionNo Patient or Public Contribution.
Frailty and Social Isolation in Breast Cancer Patients: The Moderated Mediating Role of Self‐Perception of Aging and Menopausal Symptoms
Authors: Zhang Ye , Wei Xiaoying , Zhang Ni , Zhang Yiheng , Li Na , Zhang BaoYi , Zhang Meifen 
Published: February 2025

ABSTRACTAimsTo investigate the status of social isolation among middle‐aged and elderly breast cancer patients and identify its influencing factors. Additionally, to explore the mediating role of self‐perception of aging between frailty and social isolation, as well as the moderating effect of menopausal symptoms.DesignA cross‐sectional study guided by the Strengthening the Reporting of Observational Studies in Epidemiology.MethodsThis study was conducted on middle‐aged and elderly breast cancer patients from September 2022 to February 2023 in Guangzhou, China. Related data were assessed by structural questionnaires. Correlation analysis and regression analysis were performed by SPSS 26.0 while PROCESS macro v4.0 was used to test the moderated mediation model.ResultsBreast cancer patients aged 45–82 years experienced moderate social isolation. It was influenced by educational level, residence, menopause symptoms, self‐perception of aging, and frailty. The moderated mediation model involving self‐perception of aging and menopausal symptoms for explaining how frailty causes social isolation was supported. The mediating role of self‐perception of aging gradually strengthens as menopausal symptoms become severe.ConclusionSocial isolation resulting from frailty in middle‐aged and elderly breast cancer patients is mediated by self‐perception of aging, with menopausal symptoms amplifying this effect. Interventions focused on improving self‐perception of aging and managing menopausal symptoms may help reduce social isolation by mitigating the impact of frailty.ImpactThis study highlights the importance of addressing frailty, self‐perception of aging, and menopausal symptoms in clinical nursing practice, which may help reduce social isolation among breast cancer patients.Patient or Public ContributionPatients contributed by completing the questionnaire, ensuring the accuracy and completeness of the information with assistance from the research team.
Effectiveness of an Intervention to Prevent Ultra‐Processed Foods and Added Sugar in the First Year of Life: A Multicentre Randomised Controlled Trial in Brazil
Authors: Baratto Paola S. , Hoffman Daniel J. , Valmórbida Júlia L. , Leffa Paula S. , Feldens Carlos A. , Vitolo Márcia R. 
Published: February 2025

ABSTRACTBackgroundThe early consumption of ultra‐processed foods (UPFs) and added sugars (AS) has been linked to adverse outcomes in infancy. The objective of this study was to determine the effectiveness of a dietary counselling strategy to prevent the consumption of UPFs and AS in the first year of life.MethodologyA multicentre randomised controlled trial was conducted with 516 mother–child pairs in three state capitals of Brazil. Mothers were randomly assigned to the control group (CG) or intervention group (IG) after childbirth. The IG received orientation based on UNICEF dietary guidelines and five monthly telephone calls to reinforce the intervention. Dietary intake was measured using food introduction questionnaires and 24‐h recalls during home visits at 6 and 12 months. Between‐group differences were analysed by generalised estimating equations and presented as mean difference (95% CI).ResultsChildren in the IG had lower UPF intake at 6 and 12 months of age (−20.69 g/day; 95% CI: −37.87 to −3.50; p = 0.018 and −32.51 g/day; 95% CI: −61.03 to −3.99; p = 0.025) and lower AS intake at 12 months of age (−4.92 g/day; 95% CI: −9.43 to −0.41; p = 0.033). The intervention also had a positive impact on the period of exclusive breastfeeding, reducing the offer of infant formula, cow's milk, and toddler milk in the first year of life.Principal ConclusionsThe dietary counselling strategy was effective at preventing the early consumption of UPFs and AS in the first year of life. Future research should focus on social and cultural barriers to improve adherence to infant feeding interventions.
Management of paradoxical tensions in industrial symbiosis: An exploration at the inter‐organizational level
Authors: Alosi Alice , Katana Katrin , Annunziata Eleonora , Mirata Murat , Rizzi Francesco , Frey Marco 
Published: February 2025

AbstractIndustrial symbiosis (IS) is becoming a prominent inter‐organizational approach for improved resources utilization and reduced emissions. IS literature and development efforts focus on interventions needed to overcome or eliminate various barriers, but pay inadequate attention to paradoxes that cannot be suppressed over time and require management. This study combines literature on paradox theory and IS, exploring the identification and management of paradoxical tensions in eight case studies. The results show that IS relationships trigger paradoxical tensions at the strategic and operational levels, surfaced within and between the organizations. These tensions seem to emerge from, and connected to, the persistence of a cooperation–competition paradox within organizations, when engaging with IS partners contradicts with an organization's competitiveness on the market. The study also provides insights into paradoxical tension management within and between organizations in IS relationships by, for example, shifting partner expectations in favor of IS development, separating responsibilities for IS and core activities between departments, or addressing diverging objectives between partners over time. Both at organizational and inter‐organizational levels open dialogue, transparency, and collaboration appear to play key roles in tension management. The study emphasizes the pivotal role of active paradoxical tension management—both internally at strategic and operational levels and externally with partners and facilitators.
Gendered time use, body mass index, and well‐being among adolescents in resource‐poor settings in India: The adverse role of domesticity
Authors: Ganguly Dibyasree , Vikram Kriti 
Published: February 2025

AbstractWe investigated how adolescents' time allocation across daily activities influences their body mass index and well‐being by paying explicit attention to gender and activities relevant to low‐ and middle‐income countries (LMICs). We hypothesized that the inequitable domestic burden shouldered by girls adversely affects their health and well‐being. Using data from three waves of the Young Lives Longitudinal Survey (2009, 2013, and 2016) tracking 1891 children aged 8, 12, and 15 from predominantly rural, low‐income households from South India, we analyzed gendered time use patterns and their implications. Girls spent more time on caregiving, housework, and studying at home, while boys allocated more time to school, leisure, and sleep. Random effects models revealed that time spent on caregiving and housework increased the likelihood of being overweight or obese among girls, whereas leisure time reduced it. Time in school was positively associated with girl's thinness, as was time spent on sleep for both boys and girls. Gender moderated the effects of time spent on housework and unpaid economic tasks on thinness, reducing its likelihood for girls. Subjective well‐being improved with time spent in school and studying for all adolescents. Fixed effects models revealed it worsened for girls engaged in paid work and boys engaged in leisure. Longer sleep hours improved boys' well‐being. These findings underscore that gendered time use patterns, particularly girls' unequal burden of domestic responsibilities, contribute to their increased risk of overweight and obesity. Addressing these disparities is crucial for improving adolescents' health and well‐being in resource‐poor settings in LMICs.
Trends of Large for Gestational Age and Macrosomia and Their Mediating Effect on the Association Between Diabetes Mellitus and Obstetric Hemorrhage
Authors: Chen Peiran , Mu Yi , Xie Yanxia , Wang Yanping , Liu Zheng , Li Mingrong , Liang Juan , Zhu Jun 
Published: February 2025

ABSTRACTThis study aimed to determine the prevalence of large for gestational age (LGA) and macrosomia in China from 2012 to 2021 and explore if LGA and macrosomia mediate the relationship between diabetes mellitus in pregnancy (DIP) and obstetric haemorrhage. The overall annual change rate (ACR) was calculated, and stratification analysis was performed. Mediation analysis assessed the influence of LGA and macrosomia in the association between DIP and obstetric haemorrhage. The nationwide prevalence of LGA and macrosomia was 15.8% and 6.8%, respectively. The ACR for LGA was 0.71% (95% CI, 0.66%–0.76%); pre‐2016, −0.44% (95% CI, −0.63% to −0.25%); post‐2016, −0.29% (95% CI, −0.39% to −0.19%). The ACR for macrosomia was −1.17% (95% CI, −1.24% to −1.09%); pre‐2016, −0.73% (95% CI, −1.03% to −0.43%); post‐2016, −2.42% (95% CI, −2.59% to −2.26%). In western and rural area, the ACR for LGA was 1.94% (95% CI, 1.84%–2.05%) and 1.81% (95% CI, 1.73%–1.89%), and LGA was increasing among these women in the post‐2016 period. About 7.0% of pregnant women had DIP, and the LGA and macrosomia prevalences among women with DIP were 23.7% and 10.0%, respectively. In the mediation analysis, the total excess risk associated with DIP on obstetric haemorrhage was approximately 0.21 and the proportion mediated by LGA and macrosomia was 12.10% and 11.81%, respectively. In rural areas, the proportion mediated by LGA and macrosomia was amplified to 18.34% and 16.40%. Macrosomia rates declined steadily, but LGA rates increased slightly in disadvantaged areas. LGA and macrosomia mediated the association between DIP and obstetric haemorrhage, and the mediating effect intensified in rural regions. Addressing LGA warrants management for at‐risk fetuses.
Engagement
Authors: Foruzan Sahar 
Published: February 2025

AbstractCommunity engagement, an often‐repeated phrase across academic and government sectors, is a deceptively simple, pretty phrase. Frequently it is discussed as a practice anyone can do and a nice add‐on to an existing project. However, practicing community engagement in research in a meaningful way requires a perspective shift in the way the research is done, a series of commitments to ethical relations with the communities involved and impacted by a project and its outcomes, and the solo and collective work of reflection. This article offers a look into community engagement from the perspective of a graduate student learning what it means to do this kind of work in the time of the COVID‐19 pandemic. I outline how community engagement is defined and practiced by scholars in anthropology and other fields and discuss the performance and institutionalization of community engagement. Guided by Juanita Sundberg's concept of homework, I reflect on lessons learned in the process of conducting community‐engaged research that can have an impact.