bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increasing power efficiency in the design of a low power and low phase noise CMOS LC oscillator
Authors: Soleymani Kebria Saeed , Ghonoodi Hojat 
Published: December 2020

SummaryThis study developed a local oscillator (LO) with low phase noise and low power consumption. The proposed oscillator core comprises a pair of cross‐coupled transistors, which are fed by another pair of transistors that injects current at moments close to the peak of output voltage. The position of the current injection transistors, which are inserted in series with the cross‐coupled transistors, affects the waveform of current injected into an inductive–capacitive (LC) tank. Installing a capacitor on the source node of the cross‐coupled transistors increases the current injected into the LC tank and thereby augments the output voltage amplitude and power efficiency of the LO. The resonator phase shift and Q can be corrected by adjusting the source capacitance, which filters noise. These changes reduce the phase noise to −123.4 dBc/Hz at a frequency offset of 1 MHz and improve oscillator performance with a figure of merit equal to −193.5 dBc/Hz. To evaluate the LC tank, a 5 GHz LO was simulated at 1.8 V power supply and 2.5 mW power consumption. The simulation was conducted using a practical 0.18 complementary metal–oxide–semiconductor model manufactured by the Taiwan Semiconductor Manufacturing Company. The simulation results confirmed the analytical findings.
Performance evaluation of beamforming for network throughput enhancement
Authors: Lema Gebrehiwet Gebrekrstos 
Published: December 2020

SummaryWith the advancement of mobile networks, the demand for increased throughput is continuously rising. Throughput is the amount of error‐free bits transmitted in a given period of time. Heterogeneous networks (HetNet) are widely accepted to enhance the throughput as they do have low pathloss among the others. HetNet deploys another cell under the coverage area of the macro cell. The HetNet offloads the macro cell that avoids congestion and enhances the coverage of the network. In HetNet, however, intercell interference is a major challenge that adversely degrades the throughput. In this paper, coordinated multipoint transmission (CoMP) along with a coordinated beamforming (CBF) is integrated to mitigate the intercell interference (ICI). In general, the results have shown that the proposed technique has resulted into significant interference reduction and hence improved throughput and spectral efficiency.
Embryonal rhabdomyosarcoma of breast, pleura, and retroperitoneum diagnosed from pleural fluid cytology
Authors: Rajagopal Meyyappa Devan , Stephen Norton , Gochhait Debasis , Srinivas Bheemanathi Hanuman , Siddaraju Neelaiah , Dubashi Biswajit 
Published: December 2020

AbstractEmbryonal rhabdomyosarcoma (ERMS) is a malignant small blue round cell tumor which is commonly seen in head and neck region. Breast and pleural involvement are uncommon. Rhabdomyosarcoma has been rarely reported in the body fluids like ascitic, pleural, and cerebrospinal fluid. In this article, we report an interesting case of ERMS which had deceptive small blue round cells in pleural fluid. The cytomorphological features along with a panel of immunocytochemical markers helped in arriving at the definite diagnosis. Later, biopsy from the breast lump and retroperitoneal mass also revealed the same tumor. This case is reported since it is rare to find sarcoma cells in pleural fluid and highlight the diagnostic difficulties faced during interpretation.
Diagnostic utility of endoscopic brush cytology in upper gastrointestinal malignancies
Authors: Bhutani Namita , Kumar Raj , Arora Sunil , Poswal Pooja , Singla Sham 
Published: December 2020

AbstractIntroductionThe advent of endoscopy and endoscopic biopsy has greatly facilitated the detection and diagnosis of gastrointestinal neoplasms. Brush cytology often complements and increases the sensitivity and specificity of detection of GIT lesions in many ways.Materials and MethodsThe present prospective study was conducted in the Department of Pathology in collaboration with Department of Gastroenterology at S.G.T. Medical College and University, Gurugram. A total of 50 patients suspected of having upper gastrointestinal malignancies formed the study group. After taking the detailed history, patients were subjected to endoscopy using flexible video endoscope. After brushing, biopsies were taken from the lesions and preserved in 10% formalin. The aim of the study was to evaluate the utility of endoscopic brush cytology in diagnosing upper gastrointestinal malignancies and its comparison with endoscopic biopsy.ResultsIn the present study, a total of 50 cases constituted the study group, during the period of 2018‐2019, with the age of patients ranging from 30 to 85 years. Mean age at presentation was 58 years. The most frequent age group affected was 41‐60 (44%) and most of them were men (66%). The sensitivity and positive predictive value in our study is 84.4% and 97.4%, respectively, while the specificity and negative predictive value is 100% and 50%, respectively.ConclusionTo conclude, brush cytology is a reliable, simple, safe, rapid, noninvasive yet effective, and inexpensive method of detecting malignancy of upper gastrointestinal tract.
The postnatal testosterone rebound in first‐time fathers and the quality and quantity of paternal care
Authors: Corpuz Randy , D’Alessandro Sophia , Collom Gillian K. S. 
Published: December 2020

AbstractIn human males, testosterone (T) decreases in the period following the birth of offspring. This decline has been widely interpreted as a facultative neuroendocrine response that facilitates parenting effort. Conversely, research on if (or when) this decline in T would be followed by an eventual recovery and subsequent shift away from parenting effort is lacking. In a U.S. community sample of 225 males transitioning to first‐time fatherhood, we measured T at three occasions: third trimester, infant 3 months postnatal, and infant 9–10 months postnatal. Using a piecewise latent growth curve model (GCM), we detected a T rebound from when infants were 3 months old to when infants were 9‐10 months old. The slope of this rebound was able to predict paternal care using two distinct measures: (a) an experience sampling method (ESM) that gathered data on paternal time allocation over the course of the study period and (b) independent coders rating fathers for the quality of paternal care during a structured task designed to elicit an infant fear response. As predicted, the more accelerated one’s T rebound (slope), the less time fathers invested in their infants across the study period. However, we found a positive relationship between T rebound and quality of paternal care during a challenging activity. Discussion will focus on nuanced reasons that contribute to these findings as well as speculate on the ultimate function of a human paternal T rebound.
Treg cell therapy: How cell heterogeneity can make the difference
Authors: Giganti Giulio , Atif Muhammad , Mohseni Yasmin , Mastronicola Daniela , Grageda Nathali , Povoleri Giovanni AM , Miyara Makoto , Scottà Cristiano 
Published: December 2020

AbstractCD4+CD25highCD127low/−FOXP3+ T regulatory cells are responsible for maintaining immune tolerance and controlling excessive immune responses. Treg cell use in pre‐clinical animal models showed the huge therapeutic potential of these cells in immune‐mediated diseases and laid the foundations for their applications in therapy in humans. Currently, there are several clinical trials utilizing the adoptive transfer of Treg cells to reduce the morbidity in autoimmune disorders, allogeneic HSC transplantation, and solid organ transplantation. However, a large part of them utilizes total Treg cells without distinction of their biological variability. Many studies on the heterogeneity of Treg cell population revealed distinct subsets with different functions in the control of the immune response and induction of peripheral tolerance. Some of these subsets also showed a role in controlling the general homeostasis of non‐lymphoid tissues. All these Treg cell subsets and their peculiar properties can be therefore exploited to develop novel therapeutic approaches. This review describes these functionally distinct subsets, their phenotype, homing properties and functions in lymphoid and non‐lymphoid tissues. In addition, we also discuss the limitations in using Treg cells as a cellular therapy and the strategies to enhance their efficacy.
Hot deformation characteristics and kinetics analysis for Ni‐based corrosion resistant alloy
Authors: Wang Lei , Liu Feng , Chen Hongyuan , Chi Qiang 
Published: December 2020

AbstractThe hot deformation characteristics of Nickel‐based corrosion resistant alloy was studied in the temperature range of 1050°C to 1200°C and the strain rate range of 0.001 to 0.1 second−1 by employing hot compression tests. The results show that the peak stress increases with decreasing temperature and increasing strain rate, and the apparent activation energy is about 409 kJ/mol. Based on the Avrami equation through using the critical strain (εc) and the strain for 50% DRX (ε0.5), a kinetic model for dynamic recrystallization (DRX) was established, where the model parameters could be obtained using the modified Zener‐Hollomon parameter (Z*). Applying the model, the predicted value of the steady‐state strain (εss) and the strain for maximum softening rate (εm) agree well with the experimental results. Accordingly, the relationship between εm and ε0.5 is established, which is mainly dependent on the Avrami exponent (n). When n < 3.25, εm becomes less than ε0.5 and the difference in between decreases with increasing the strain rate or decreasing the deformation temperature. Finally, through observing DRX microstructure under different deformation conditions, a power law relation between DRX grain size (Ddrx) and Z*, with an exponent of −0.36, was found.
Thermo‐mechanical behaviour of cross‐laminated timber slabs under standard and natural fires
Authors: Mindeguia Jean‐Christophe , Mohaine Siyimane , Bisby Luke , Robert Fabienne , McNamee Robert , Bartlett Alastair 
Published: December 2020

SummaryThe results presented in this paper are part of a multi‐partner collaborative project named ‘The Épernon Fire Tests Programme’, the purpose of which is to analyse the different behaviours of combustible and non‐combustible loaded structures when they are tested under standard and ‘natural’ fires. The project has several objectives, such as quantification of the energy participation of combustible materials in fire tests, the influence of combustible surfaces and ventilation factors on the dynamics of compartment fires, and the thermo‐mechanical behaviour of concrete and timber elements under natural fires. This paper focuses on the thermo‐mechanical behaviour of cross‐laminated timber (CLT) slabs under standard and natural fires. The objective is to provide new experimental data on the behaviour of unprotected CLT slabs exposed to fire. In addition, we present a detailed analysis of the thermo‐mechanical behaviour of the slabs, particularly aimed at better understanding the mechanical failures of some of the slabs during and after fire exposure.
Impact of yoga and exercises on polycystic ovarian syndrome risk among adolescent schoolgirls in South India
Authors: Selvaraj Valarmathi , Vanitha Jain , Dhanaraj Fabiola M. , Sekar Prema , Babu Anitha Rajendra 
Published: December 2020

AbstractBackgroundTo identify the adolescent school girls with risk for polycystic ovarian syndrome (PCOS), assess their risk status, and evaluate the impact of lifestyle modifications on PCOS risk reduction.MethodsAn experimental research was conducted among adolescent girls belonging to two Government run schools in Tiruvallur district of Tamil Nadu state, India, from 6 June to 9 December 2016. A standard risk assessment questionnaire was adopted for risk assessment after making few modifications (Cronbach alpha 0.86). The experimental group received lifestyle modifications (yoga for two months and walking exercise for two months), with no such intervention provided for the control group. The impact of these interventions was assessed in terms of risk minimization and a P value less than .05 was considered statistically significant.ResultsA total of 204 (control—102; experimental—102) girls with statistically insignificant difference in demographic features were studied. During the pretest, 85.2% (n = 87) in the experimental group and 83.3% (n = 85) the controls had “moderate risk” for PCOS. Girls with “high risk” level of PCOS were 14.8% (n = 15) and 15.7% (n = 17) in the experimental group and the control group, respectively. In posttest‐1 (after yoga sessions) risk assessment, 71.6% had “moderate risk,” 5.9% had “high risk” in the experimental group, whereas 87.3% had “moderate risk” and 12.7% had “high risk” in the control group. In posttest‐2 (after exercise sessions) risk assessment, 48% had “moderate risk” and 0% had high risk in the experimental group, whereas 88.2% were “moderate risk” and 11.8% were “high risk” in the control group. Repeated measure ANOVA with Greenhouse‐Geisser correction showed mean risk reduction score statistically significant between pretest and post‐test (33.38 ± 7.28 vs 22.75 ± 12.09, respectively mean difference is 10.63: F = 236.12 P < .001), suggesting a positive correlation with the intervention.ConclusionsYoga and exercise were beneficial in minimizing PCOS risk, as reflected in the risk assessment score. More such interventions, covering different schools, could provide larger health benefits.
Formal training in cardiotocograph interpretation of healthcare practitioners improves interpretation: A prospective descriptive analytical study in a resource constrained setting
Authors: Goldman Bernardus , Naidoo Thinagrin 
Published: December 2020

AbstractObjectiveTo evaluate the effect of structured training on the cardiotocograph (CTG) interpretation skills of healthcare workers (HCWs) involved in obstetric care in a recourse constrained setting.MethodIn all, 218 HCWs completed pre‐ and post‐intervention questionnaires. The intervention involved structured teaching on technical aspects of CTG monitoring, fetal physiology, and adaptation to stress, and a holistic approach to interpretation. Descriptive statistics were used to summarize demographic characteristics, frequencies, and percentages for categorical data.ResultsOnly 26.2% of participants felt that their pre‐graduate training was adequate; this was reflected by the poor baseline knowledge in CTG interpretation (56% misinterpreted) and lack of knowledge regarding technical aspects of CTG monitoring in 48.8% of participants. The training session led to a 65% improvement in technical aspects and interpretation. Those HCWs not receiving continuous training showed a more significant improvement (P < 0.001) and there was a 100% improvement in knowledge regarding the required documentation before commencing monitoring. Most (99.5%) HCWs acknowledged an improvement in knowledge, and 96.2% would participate in similar mandatory education sessions.ConclusionThese findings highlight the fact that training in CTG monitoring is warranted and desired by HCWs. It also supports the implementation of structured CTG education in resource‐constrained settings.
Role of alkali metal oxide type on the degradation and in vivo biocompatibility of soda‐lime‐borate bioactive glass
Authors: Omar Areg E. , Ibrahim Ahlam M. , Abd El‐Aziz Tamer H. , Al‐Rashidy Zainab M. , Farag Mohammad M. 
Published: December 2020

AbstractIn this work, it is the first time to study the effect of replacing of Na2O by a fixed amount of Li2O or K2O in soda‐lime‐borate glass on its in vivo biocompatibility. The glass composition was based on xM2O‐20x Na2O20 CaO60 B2O3, (wt %), where, M2OLi2O and K2O, and consequently, samples encoded BN100, BK50, and BL50. The degradation test was carried out in 0.25 M K2HPO4 solution. The in vivo test was performed in the femoral bone defect of Sprague–Dawley adult male rat. Following up bone formation was conducted by the histological analyses and bone formation markers (alkaline phosphatase [ALP] and osteocalcin [OCN]). Furthermore, the glass effect on the liver and kidney functions was addressed in this study using (alanine transaminase [ALT] and aspartate transaminase [AST]) and (urea and creatinine), respectively. The results of the degradation test showed that the glass dissolution rate was increased by incorporating of K2O, and its ion release was occurred by a diffusion‐controlled process. Moreover, in vivo bioactivity test showed that serum activity of ALP, OCN level, and the newly formed bone was higher in BL50‐implanted group than that of BN100 andBK50at 3 w and 6 w post‐surgery. As well as, implantation of all glass samples in the femoral bone defect did not alter the liver and kidney functions. In conclusion, the synthesized borate glass was well served as a controlled delivery system for Li+ ion release, which enhanced bone formation as shown from the bone formation markers (ALP and OCN).
Electron injection for aromatic metamorphosis of indole
Authors: Yorimitsu Hideki 
Published: December 2020

AbstractAromatic metamorphosis, endocyclic transformations of aromatic compounds, has been emerging as a new synthetic strategy in organic synthesis. This counterintuitive strategy necessitates very powerful reactions that can surmount aromaticity and the strong carbon–heteroatom bonds of the heteroaromatic rings. This Short Account describes the development of the currently most powerful elementary reaction for aromatic metamorphosis, which is electron injection from lithium metal. Exceptionally robust and aromatic N‐phenylindole is subjected to the electron injection, resulting in the formation of the corresponding dianionic intermediate through reductive ring‐opening. A trapping reaction of the dianionic intermediate with organoboronic acid pinacol esters provides benzazaborines, which are attractive BN‐isosteres of naphthalenes. The electron injection helps establishing aromatic metamorphosis as a reliable synthetic methodology to provide novel useful molecules.
Katanin P60 and P80 in papillary thyroid carcinoma patients: Indicators for exacerbated tumor features and worse disease‐free survival
Authors: Chen Qinggui , Lin Fusheng , Lin Ende , Huang Qinghe , Wu Guoyang 
Published: December 2020

AbstractBackgroundThis study aimed to explore the clinical implications of katanin P60 and P80 (katanin P60/P80) regarding their correlations with clinicopathological features and survival profiles in papillary thyroid carcinoma (PTC) patients.MethodsTumor tissue and paired adjacent tissue specimens were obtained from 172 PTC patients who underwent lobectomy or thyroidectomy. Besides, immunohistochemistry assay and immunoreactive (IR) score (multiplying staining intensity score by density score) were used to determine katanin P60/P80 expressions. According to IR score (from 0 ~ 12), katanin P60/P80 expressions were classified as low (IR score 0 ~ 3) and high (IR score 4 ~ 12) expressions.ResultsBoth katanin P60/P80 expressions were highly expressed in tumor tissue compared with adjacent tissue. Besides, tumor katanin P60 expression positively correlated with tumor katanin P80 expression. Tumor katanin P60 high expression correlated with larger tumor size, extrathyroidal invasion, advanced pT stage, pN stage, and pTNM stage, while no correlation of tumor katanin P60 expression with age or gender was observed; tumor katanin P80 high expression correlated with advanced pN stage and pTNM stage, whereas there was no correlation of tumor katanin P80 expression with age, gender, tumor size, extrathyroidal invasion, or pT stage. Furthermore, both tumor katanin P60/P80 high expressions correlated with shorter accumulating disease‐free survival. As for overall survival (OS), neither tumor katanin P60 nor P80 expression correlated with OS.ConclusionKatanin P60/P80 measurement might assist with tumor management and prognosis surveillance in PTC patients.
Luteolin enhances the antitumor efficacy of oncolytic vaccinia virus that harbors IL‐24 gene in liver cancer cells
Authors: Wang Chunming , Li Qiang , Xiao Boduan , Fang Huiling , Huang Biao , Huang Fang , Wang Yigang 
Published: December 2020

AbstractBackgroundInterleukin 24 (IL‐24) is an IL‐10 family member and a secreted cytokine characterized by cancer‐targeted toxicity and can activate apoptosis by sensitizing cancer cells to chemotherapy. Cytotoxic effects of luteolin on different types of cancer cells suppress their growth by acting on the components of the apoptosis signaling cascade. Therefore, our study aimed to prove whether oncolytic vaccinia virus (VV) that harbors IL‐24 (VV‐IL‐24) combine with luteolin exerts a synergistic inhibitory effect in liver cancer cells.MethodsImpacts on cell viability of VV‐IL‐24 and luteolin were assessed by MTT in various liver cancer cell lines. Then, liver cancer cell apoptosis was analyzed via flow cytometry and Western blotting. Besides, the MHCC97‐H xenograft mouse model was employed as a means of assessing in vivo antitumor efficacy.ResultsMTT assay confirmed that the combination treatment decreased liver cancer cells viability to a greater degree than treatment with VV‐IL‐24 or luteolin alone. Flow cytometry and Western blot assay proved that VV‐IL‐24 plus luteolin induced more liver cancer cells apoptosis than single treatment. Furthermore, in the MHCC97‐H xenograft model, 15 days of treatment with VV‐IL‐24 plus luteolin inhibited tumor growth significantly more than single treatment.ConclusionThese data confirm that the synergistic mechanism of VV‐IL‐24 and luteolin elicits a stronger tumor growth inhibition than any single therapy. Thus, the combination of VV‐IL‐24 and luteolin could provide the basis for preclinical research in the treatment of liver cancer.
Zinc finger E‐box binding homeobox 1 and atherosclerosis: New insights and therapeutic potential
Authors: Li Heng , Zou Jin , Yu Xiao‐Hua , Ou Xiang , Tang Chao‐Ke 
Published: December 2020

AbstractZinc finger E‐box binding homeobox 1 (ZEB1), an important transcription factor belonging to the ZEB family, plays a crucial role in regulating gene expression required for both normal physiological and pathological processes. Accumulating evidence has shown that ZEB1 participates in the initiation and progression of atherosclerotic cardiovascular disease. Recent studies suggest that ZEB1 protects against atherosclerosis by regulation of endothelial cell angiogenesis, endothelial dysfunction, monocyte‐endothelial cell interaction, macrophage lipid accumulation, macrophage polarization, monocyte‐vascular smooth muscle cell (VSMC) interaction, VSMC proliferation and migration, and T cell proliferation. In this review, we summarize the recent progress of ZEB1 in the pathogenesis of atherosclerosis and provide insights into the prevention and treatment of atherosclerotic cardiovascular disease.
Ruxolitinib is effective in the treatment of a patient with refractory T‐ALL
Authors: Jaramillo Sonia , Hennemann Hannah , Horak Peter , Teleanu Veronica , Heilig Christoph E. , Hutter Barbara , Stenzinger Albrecht , Glimm Hanno , Goeppert Benjamin , Müller‐Tidow Carsten , Fröhling Stefan , Schönland Stefan , Schlenk Richard F. 
Published: December 2020

AbstractT‐cell acute lymphoblastic leukemia (T‐ALL) is a rare, aggressive T‐cell malignancy. Chemotherapy alone cures only 25‐45% of the cases, thus, novel treatment agents and strategies are urgently needed. We assessed the efficacy of ruxolitinib in a patient with a cutaneous relapse after allogeneic blood cell transplantation of a refractory T‐ALL with a Janus kinase 3 (JAK3) mutation. In this case report, we were able to show the potential benefit of the JAK inhibitor ruxolitinib in JAK3‐mutated refractory T‐ALL and emphasize the importance of integrating molecular markers in current treatment decision making for patients with T‐ALL.