bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydroxyplumbopyrochlore, (Pb1.5,□0.5)Nb2O6(OH), a new member of the pyrochlore group from Jabal Sayid, Saudi Arabia
Authors: Li Ting , Li Ziying , Fan Guang , Fan Honghai , Zhong Jun , Jahdali Naser S. , Qin Mingkuan , Jehani Abdullah M. , Wang Fenggang , Nahdi Mubarak M. 
Published: September 2020

ABSTRACTA new mineral species of the pyrochlore supergroup, hydroxyplumbopyrochlore (IMA2018-145), (Pb1.5,□0.5)Nb2O6(OH), has been discovered in the Jabal Sayid peralkaline granitic complex of the Arabian Shield, Saudi Arabia. It is associated with quartz, microcline, ‘biotite’, rutile, zircon, calcite, rhodochrosite, columbite-(Fe), goethite, thorite, bastnäsite-(Ce), xenotime-(Y), samarskite-(Y), euxenite-(Y), hydropyrochlore and fluornatropyrochlore. Hydroxyplumbopyrochlore usually shows euhedral octahedra, slightly rhombic dodecahedra and cubes or their combination (0.01–0.06 mm). The mineral is pale yellow to pale brown, transparent with white streak, and has adamantine to transparent lustre. It is brittle with conchoidal fracture. No cleavage or parting are observed. It is isotropic and non-fluorescent. The average microhardness is 463.4 kg mm–2. The calculated density is 6.474 g cm–3.Hydroxyplumbopyrochlore belongs to the cubic crystal system and exhibits the space group Fd$\bar{3}$m with unit-cell parameters a = 10.5456(6) Å, V = 1172.8(2) Å3 and Z = 8. Electron microprobe analysis gave (6-point average composition, wt.%): CaO 0.32, SrO 0.16, FeO 0.17, Ce2O3 0.07, Pr2O3 0.02, PbO 51.69, Nb2O5 40.06, SiO2 0.05, TiO2 1.68, Ta2O5 4.74, H2Ocalc 0.95, total 99.90, yielding the empirical formula (Pb1.34Ca0.03Fe0.01Sr0.01□0.61)Σ2(Nb1.75Ti0.12Ta0.12Si0.01)Σ2O6(OH0.53O0.08□0.39)Σ1, where □ = vacancy. The Raman spectrum of hydroxyplumbopyrochlore contains the characteristic bands of O–H vibrations and no bands for H2O vibrations.
Platelet activation and platelet-monocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19
Authors: Hottz Eugenio D. , Azevedo-Quintanilha Isaclaudia G. , Palhinha Lohanna , Teixeira Lívia , Barreto Ester A. , Pão Camila R. R. , Righy Cassia , Franco Sérgio , Souza Thiago M. L. , Kurtz Pedro , Bozza Fernando A. , Bozza Patrícia T. 
Published: September 2020

Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emergent pathogen responsible for the coronavirus disease 2019 (COVID-19). Since its emergence, the novel coronavirus has rapidly achieved pandemic proportions causing remarkably increased morbidity and mortality around the world. A hypercoagulability state has been reported as a major pathologic event in COVID-19, and thromboembolic complications listed among life-threatening complications of the disease. Platelets are chief effector cells of hemostasis and pathological thrombosis. However, the participation of platelets in the pathogenesis of COVID-19 remains elusive. This report demonstrates that increased platelet activation and platelet-monocyte aggregate formation are observed in severe COVID-19 patients, but not in patients presenting mild COVID-19 syndrome. In addition, exposure to plasma from severe COVID-19 patients increased the activation of control platelets ex vivo. In our cohort of COVID-19 patients admitted to the intensive care unit, platelet-monocyte interaction was strongly associated with tissue factor (TF) expression by the monocytes. Platelet activation and monocyte TF expression were associated with markers of coagulation exacerbation as fibrinogen and D-dimers, and were increased in patients requiring invasive mechanical ventilation or patients who evolved with in-hospital mortality. Finally, platelets from severe COVID-19 patients were able to induce TF expression ex vivo in monocytes from healthy volunteers, a phenomenon that was inhibited by platelet P-selectin neutralization or integrin αIIb/β3 blocking with the aggregation inhibitor abciximab. Altogether, these data shed light on new pathological mechanisms involving platelet activation and platelet-dependent monocyte TF expression, which were associated with COVID-19 severity and mortality.
Evaluation of the college-based HIV/AIDS education policy in Beijing, China: a mixed method approach
Authors: Zheng Yunting , Zhang Xin , Sun Xinying , Shi Yuhui , Chang Chun 
Published: September 2020

Abstract
Background
From 2010 to 2015, there was a twofold growth of new HIV/AIDS infection in Beijing among young students aged 15–24. HIV/AIDS education was found effective in promoting positive behavior change related to HIV/AIDS prevention. However, little evidence was found on the evaluation of HIV/AIDS education policy. This study aimed to evaluate the college-based HIV/AIDS education policy in Beijing.

Methods
By using a mixed method approach, the current study reviewed college-based HIV/AIDS education policy at national level and in Beijing from 1985 to 2016 and conducted policy content analysis to evaluate the policy ability to structure implementation. Cross-sectional surveys in 2006 and 2016 were used to evaluate college’s implementation of relevant policies. T test, χ2 test, and logistic regression were used to analyze college students’ perception of HIV/AIDS education provided in their colleges and their knowledge of HIV/AIDS and their risk factors.

Results
Fourteen pieces of national policy and four pieces of Beijing’s policy were identified. Policy’s ability to structure implementation was at moderate level. The percentage of students in Beijing who ever perceived HIV/ADIS education at colleges decreased from 71.14 to 39.80%, and the percentage of students with comprehensive knowledge of HIV/AIDS dropped from 50.00% in 2006 to 40.42% in 2016.

Conclusions
HIV/AIDS education in college had drawn considerable attentions from the Chinese government, while the policy implementation needs further strengthening.
Multi-compartment chemical characterization and risk assessment of chemicals of emerging concern in freshwater systems of western Kenya
Authors: Kandie Faith Jebiwot , Krauss Martin , Massei Riccardo , Ganatra Akbar , Fillinger Ulrike , Becker Jeremias , Liess Matthias , Torto Baldwyn , Brack Werner 
Published: September 2020

Abstract
Background
Within the last decades, there has been increasing research on the occurrence of chemicals of emerging concern (CECs) in aquatic ecosystems due to their potential adverse effects on freshwater organisms and risk to human health. However, information on CECs in freshwater environments in sub-Saharan countries is very limited. Here, we investigated the occurrence of CECs in snails and sediments collected from 48 sites within the Lake Victoria South Basin, Kenya, which have been previously investigated for water contamination. Samples were analyzed by liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) with a target list of 429 compounds.

Results
In total, 30 compounds have been detected in snails and 78 in sediment samples, compared to 79 previously identified compounds in water. By extending the monitoring of CECs to snails and sediments, we found 68 compounds that were not previously detected in water. These compounds include the anti-cancer drug anastrozole, detected for the first time in the Kenyan environment. Individual compound concentrations were detected up to 480 ng/g wet weight (N-ethyl-o-toluenesulfonamide) in snails and 110 ng/g organic carbon (pirimiphos-methyl) in sediments. Higher contaminant concentrations were found in agricultural sites than in areas not impacted by anthropogenic activities. Crustaceans were the organisms at greatest toxic risk from sediment contamination [toxic unit (TU) up to 0.99] with diazinon and pirimiphos-methyl driving this risk. Acute and chronic risks to algae were driven by diuron (TU up to 0.24), whereas fish were found to be at low-to-no acute risk (TU up to 0.007).

Conclusions
The compound classes present at the highest frequencies in all matrices were pesticides and biocides. This study shows substantial contamination of surface water in rural western Kenya. By filling data gaps on contamination of sediments and aquatic biota, our study reveals that CECs pose a substantial risk to environmental health in Kenya demanding for monitoring and mitigation.
Urban heat resilience at the time of global warming: evaluating the impact of the urban parks on outdoor thermal comfort
Authors: Aram Farshid , Solgi Ebrahim , Garcia Ester Higueras , Mosavi Amir 
Published: September 2020

Abstract
Background
In densely populated urban centers, increased air temperature due to urban heat island (UHI) effect can undermine the thermal comfort and health of citizens. Research has shown that large urban parks can mitigate the effect of UHIs and improve thermal comfort, especially in the warmer months of the year when temperature changes are more noticeable. This study investigated the cooling effect intensity (CEI) of the Retiro Park in the center of Madrid at three different distances from its southern edge and the impact of this cooling effect on thermal comfort from physiological and psychological perspectives. This investigation was performed by measuring microclimate data and conducting a survey simultaneously during the summer days.

Results
The results showed that the CEI of the park varies with distance from its edge. Because of this effect, air temperature within the 130 m and 280 m distance of the park was, respectively, 1.6 °C and 0.9 °C lower than the temperature at the 520 m distance (the nearest heat island). After examining the effect of the park in terms of physiological equivalent temperature (PET), it was found that the PET at the 130 m and 280 m distance of the park was 9.3% and 5.4% less than the PET in the heat island domain. More than 81% of the respondents (in all three areas) had a mental image of the park as the place where they would experience the highest level of outdoor thermal comfort, and this rate was higher in the areas closer to the park. The analysis of citizens’ responses about perceived thermal comfort (PTC) showed that citizens in areas with higher CEI had perceived a higher degree of thermal comfort from the psychological perspective.

Conclusion
This study demonstrates the significant role of large urban parks located in the core of the populated cities in providing thermal comfort for citizens from both physiological and psychological perspectives. Additionally, the results of this study demonstrated that among the environmental (natural and artificial) factors around the park (topography, urban structure, etc.), the aspect ratio has the greatest impact on thermal comfort.
Comprehensive host-pathogen protein-protein interaction network analysis
Authors: Khorsand Babak , Savadi Abdorreza , Naghibzadeh Mahmoud 
Published: September 2020

Abstract
Background
Infectious diseases are a cruel assassin with millions of victims around the world each year. Understanding infectious mechanism of viruses is indispensable for their inhibition. One of the best ways of unveiling this mechanism is to investigate the host-pathogen protein-protein interaction network. In this paper we try to disclose many properties of this network. We focus on human as host and integrate experimentally 32,859 interaction between human proteins and virus proteins from several databases. We investigate different properties of human proteins targeted by virus proteins and find that most of them have a considerable high centrality scores in human intra protein-protein interaction network. Investigating human proteins network properties which are targeted by different virus proteins can help us to design multipurpose drugs.

Results
As host-pathogen protein-protein interaction network is a bipartite network and centrality measures for this type of networks are scarce, we proposed seven new centrality measures for analyzing bipartite networks. Applying them to different virus strains reveals unrandomness of attack strategies of virus proteins which could help us in drug design hence elevating the quality of life. They could also be used in detecting host essential proteins. Essential proteins are those whose functions are critical for survival of its host. One of the proposed centralities named diversity of predators, outperforms the other existing centralities in terms of detecting essential proteins and could be used as an optimal essential proteins’ marker.

Conclusions
Different centralities were applied to analyze human protein-protein interaction network and to detect characteristics of human proteins targeted by virus proteins. Moreover, seven new centralities were proposed to analyze host-pathogen protein-protein interaction network and to detect pathogens’ favorite host protein victims. Comparing different centralities in detecting essential proteins reveals that diversity of predator (one of the proposed centralities) is the best essential protein marker.
GMIEC: a shiny application for the identification of gene-targeted drugs for precision medicine
Authors: Malagoli Tagliazucchi Guidantonio , Taccioli Cristian 
Published: September 2020

Abstract

Background
Precision medicine is a medical approach that takes into account individual genetic variability and often requires Next Generation Sequencing data in order to predict new treatments. Here we present GMIEC, Genomic Modules Identification et Characterization for genomics medicine, an application that is able to identify specific drugs at the level of single patient integrating multi-omics data such as RNA-sequencing, copy-number variation, methylation, Chromatin Immuno-Precipitation and Exome/Whole Genome sequencing. It is also possible to include clinical data related to each patient. GMIEC has been developed as a web-based R-Shiny platform and gives as output a table easy to use and explore.

Results
We present GMIEC, a Shiny application for genomics medicine. The tool allows the users the integration of two or more multiple omics datasets (e.g. gene-expression, copy-number), at sample level, to identify groups of genes that share common genomic and corresponding drugs. We demonstrate the characteristics of our application by using it to analyze a prostate cancer data set.

Conclusions
GMIEC provides a simple interface for genomics medicine. GMIEC was develop with Shiny to provide an application that does not require advanced programming skills. GMIEC consists of three sub-application for the analysis (GMIEC-AN), the visualization (GMIEC-VIS) and the exploration of results (GMIEC-RES). GMIEC is an open source software and is available at https://github.com/guidmt/GMIEC-shiny
Correlation of serum N-Acetylneuraminic acid with the risk and prognosis of acute coronary syndrome: a prospective cohort study
Authors: Li Miao-Nan , Qian Shao-Huan , Yao Zhuo-Ya , Ming Sheng-Ping , Shi Xiao-Jun , Kang Ping-Fang , Zhang Ning-Ru , Wang Xiao-Jing , Gao Da-Sheng , Gao Qing , Zhang Heng , Wang Hong-Ju 
Published: September 2020

Abstract
Background
N-acetylneuraminic acid (Neu5Ac) is a functional metabolite involved in coronary artery disease (CAD). We aimed to evaluate the relationship between serum Neu5Ac and the risk and prognosis of acute coronary syndrome (ACS) in a real-world prospective study.

Methods
Patients with suspected ACS who underwent coronary angiography were included. Serum Neu5Ac was measured at admission. Coronary lesion severity was evaluated by Gensini Score. GRACE risk stratification was performed at admission. Major adverse cardiac events (MACEs) were recorded during follow-up.

Results
A total of 766 patients, including 537 with unstable angina (UAP), 100 with myocardial infarction (MI), and 129 without CAD were included. The circulating Neu5Ac level was significantly higher in patients with MI (median [1QR]: 297[220, 374] ng/ml) than in those with UAP (227 [114, 312] ng/ml) or without CAD (207 [114, 276] ng/ml; both p < 0.001). Serum level of Neu5Ac was positively correlated with age, hypertension, serum uric acid, creatinine, MB isoform of creatine kinase (CK-MB), and Gensini score (all p < 0.05). Receiver operating characteristic curve analysis showed that a higher serum Neu5Ac was potentially associated with MI and high-risk GRACE stratification in ACS patients. Logistic analysis identified only elevated serum Neu5Ac as an independent predictor of MACEs in these patients (odds ratio [OR]: 1.003, 95% confidence interval [CI]: 1.002–1.005, p < 0.001).

Conclusions
Serum Neu5Ac is associated with myocardial injury, GRACE risk category, and prognosis in ACS patients.
Chronic Obstructive Pulmonary Disease (COPD) management in the community: how could primary care team contribute?
Authors: Chen X. R. Catherine , Leung S. H. , Li Y. C. 
Published: September 2020

Abstract
Background
Chronic obstructive pulmonary disease (COPD) is a progressive lung disease commonly encountered in primary care. This study aimed to audit COPD care at primary care clinics of Hong Kong and to work out improvement strategies.

Method
All COPD patients aged 40 or above who had been followed up at 13 public primary care clinics of Kowloon Central Cluster (KCC) under the Hospital Authority of Hong Kong (HAHK) were included in this clinic audit. Evidence-based audit criteria and performance standards were established after thorough literature review. Phase 1 was from 1st April 2016 to 31st March 2017, with deficiencies of care identified. It was followed by a one-year implementation phase through which a series of improvement strategies were executed. Outcome of the enhancement was reviewed during Phase 2 from 1st April 2018 to 31st March 2019. Chi-square test and student’s t test were used to detect statistically significant changes between Phase 1 and Phase 2.

Results
A total of 2358 COPD cases were identified in Phase 1 where 658 of them were smokers. Of those smokers, 332 (50.5%) had been referred to Smoking Counselling and Cessation Service (SCCS) and 289 (43.9%) actually attended it. 991 cases (42%) received Seasonal Influenza Vaccine (SIV) and 938 cases (39.8%) received Pneumococcal Vaccine (PCV). 698 patients (29.6%) had spirometry done before and 423 patients (17.9%) had been admitted to hospital due to acute exacerbation of COPD (AECOPD). With the concerted effort taken during the implementation phase, Phase 2 data showed significant improvement in nearly all criteria. There was a marked increase in the SIV and PCV uptake rate, spirometry performance rate and most importantly, a significant reduction in AECOPD rate leading to hospital admission (13.5%, P = 0.000043). However, the referral rate and attendance rate of SCCS among smokers remained stagnant (P > 0.05).

Conclusion
Via a systematic team approach, COPD care at primary care clinics of KCC under HAHK had been significantly improved for most of the audit criteria, which in turn reduced the burden of the healthcare system.
Decision-making for receiving paid home care for dementia in the time of COVID-19: a qualitative study
Authors: Giebel Clarissa , Hanna Kerry , Cannon Jacqueline , Eley Ruth , Tetlow Hilary , Gaughan Anna , Komuravelli Aravind , Shenton Justine , Rogers Carol , Butchard Sarah , Callaghan Steve , Limbert Stan , Rajagopal Manoj , Ward Kym , Shaw Lisa , Whittington Rosie , Hughes Mishca , Gabbay Mark 
Published: September 2020

Abstract
Background
The lockdown imposed in the UK on the 23rd of March and associated public health measures of social distancing are likely to have had a great impact on care provision. The aim of this study was to explore the decision-making processes of continued paid home care support for dementia in the time of COVID-19.

Methods
Unpaid carers caring for a person living with dementia (PLWD) who were accessing paid home care before COVID-19 and residing in the UK were eligible to take part. Participants were interviewed over the phone and asked about their experiences of using paid home care services before and since COVID-19, and their decision-making processes of accessing paid home care since the outbreak and public health restrictions.

Results
Fifteen unpaid carers, who were also accessing paid care support for the PLWD before COVID-19, were included in the analysis. Thematic analysis identified three overarching themes: (1) Risk; (2) Making difficult choices and risk management; and (3) Implications for unpaid carers. Many unpaid carers decided to discontinue paid carers entering the home due to the risk of infection, resulting in unpaid carers having to pick up the care hours to support the person living with dementia.

Conclusions
This is the first study to report on the impact of COVID-19 on paid home care changes in dementia. Findings raise implications for providing better Personal Protective Equipment for paid carers, and to support unpaid carers better in their roles, with the pandemic likely to stay in place for the foreseeable future.
Functional Independence Measure score is associated with mortality in critically ill elderly patients admitted to an intermediate care unit
Authors: D’Andrea A. , Le Peillet D. , Fassier T. , Prendki V. , Trombert V. , Reny J-L , Roux X. 
Published: September 2020

Abstract
Background
Age alone is not a robust predictor of mortality in critically ill elderly patients. Chronic health status and functional status before admission could be better predictors. This study aimed to determine whether functional status, assessed using the Functional Independence Measure (FIM), could be an independent predictor of mortality in a geriatric population admitted to an intermediate care unit (IMCU).

Methods
A monocentric, retrospective, observational study of all patients aged ≥75 years old admitted to Geneva University Hospitals’ geriatric IMCU between 01.01.2012 and 31.05.2016. The study’s primary outcome metrics were one-year mortality’s associations with a pre-admission FIM score and other relevant prospectively recorded prognostic variables.

Results
A total of 345 patients were included (56% female, mean age 85 +/− 6.5 years). Mean FIM score was 66 +/− 26. One-year mortality was 57%. Dichotomized low (≤ 63) and high FIM (> 63) scores were associated with one-year mortalities of 68 and 44%, respectively. Logistic regression calculations found an association between pre-admission FIM score and one-year mortality (p <  0.0001), including variables usually associated with mortality (e.g., age, sex, comorbidities, mini-mental health state score, renal function). Multivariate survival analysis showed a significant difference between groups, with a hazard ratio of 0.29 (95% CI: 0.13–0.65) for patients with high FIM scores.

Conclusions
In the present study, higher functional status, assessed using the FIM tool before admission to an IMCU, was significantly and independently associated with lower one-year mortality. This opens up perspectives on the potential value of FIM for establishing a finer prognosis and better triage of critically ill older patients.