bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supporting Ecosystem-based Fisheries Management in meeting multiple objectives for sustainable use of coral reef ecosystems
Authors: Weijerman Mariska , Oyafuso Zack S , Leong Kirsten M , Oleson Kirsten L L , Winston Morgan 
Published: September 2020

Abstract
Ecosystem-based Fisheries Management is a holistic management approach that integrates the dynamics of an entire ecosystem, including societal dimensions. However, this approach seldom lives up to its promise because economic and social objectives are rarely specified. To fill this gap, we explored how an ecosystem model could better integrate economic and social objectives, using the coral reef ecosystem around Hawai`i as a case study. After meeting with stakeholders and conducting a literature review of policy/strategy documents, we identified societal and ecological objectives and associated performance indicators for which data existed. We developed a social–ecological system conceptual framework to illustrate the relationships between ecological and social state components. This framework was the foundation for the development of the final social–ecological system model which we simulated using an Ecopath with Ecosim model. We simulated four gear/species restrictions for the reef-based fishery, two fishing scenarios associated with the opening of hypothetical no-take Marine Protected Areas for the deepwater-based fishery, and a Constant Effort (No Action) scenario. Despite limitations in the model, our approach shows that when social and economic objectives and social–ecological relationships are defined, we can quantify the trade-offs among the identified societal objectives to support managers in choosing among alternative interventions.
Quantitative Singularity Theory for Random Polynomials
Authors: Breiding Paul , Keneshlou Hanieh , Lerario Antonio 
Published: September 2020

Abstract
Motivated by Hilbert’s 16th problem we discuss the probabilities of topological features of a system of random homogeneous polynomials. The distribution for the polynomials is the Kostlan distribution. The topological features we consider are type-$W$ singular loci. This is a term that we introduce and that is defined by a list of equalities and inequalities on the derivatives of the polynomials. In technical terms a type-$W$ singular locus is the set of points where the jet of the Kostlan polynomials belongs to a semialgebraic subset $W$ of the jet space, which we require to be invariant under orthogonal change of variables. For instance, the zero set of polynomial functions or the set of critical points fall under this definition. We will show that, with overwhelming probability, the type-$W$ singular locus of a Kostlan polynomial is ambient isotopic to that of a polynomial of lower degree. As a crucial result, this implies that complicated topological configurations are rare. Our results extend earlier results from Diatta and Lerario who considered the special case of the zero set of a single polynomial. Furthermore, for a given polynomial function $p$ we provide a deterministic bound for the radius of the ball in the space of differentiable functions with center $p$, in which the $W$-singularity structure is constant.
Cathepsin G Degrades Staphylococcus aureus Biofilms
Authors: Kavanaugh Jeffrey S , Leidal Kevin G , Nauseef William M , Horswill Alexander R 
Published: September 2020

Abstract
Polymorphonuclear leukocytes (PMN) phagocytose and kill individual bacteria but are far less efficient when challenged with bacterial aggregates. Consequently, growth within a biofilm affords Staphylococcus aureus some protection but PMN penetrate S. aureus biofilms and phagocytose bacteria, suggesting that enzymes released through neutrophil degranulation degrade biofilms into fragments small enough for phagocytosis. Here we show that the capacity of PMN to invade biofilms depended largely on the activity of secreted cathepsin G.
Evidence of memory from brain data
Authors: Murphy Emily R D , Rissman Jesse 
Published: September 2020

Abstract
Much courtroom evidence relies on assessing witness memory. Recent advances in brain imaging analysis techniques offer new information about the nature of autobiographical memory and introduce the potential for brain-based memory detection. In particular, the use of powerful machine-learning algorithms reveals the limits of technological capacities to detect true memories and contributes to existing psychological understanding that all memory is potentially flawed. This article first provides the conceptual foundation for brain-based memory detection as evidence. It then comprehensively reviews the state of the art in brain-based memory detection research before establishing a framework for admissibility of brain-based memory detection evidence in the courtroom and considering whether and how such use would be consistent with notions of justice. The central question that this interdisciplinary analysis presents is: if the science is sophisticated enough to demonstrate that accurate, veridical memory detection is limited by biological, rather than technological, constraints, what should that understanding mean for broader legal conceptions of how memory is traditionally assessed and relied upon in legal proceedings? Ultimately, we argue that courtroom admissibility is presently a misdirected pursuit, though there is still much to be gained from advancing our understanding of the biology of human memory.
Music Improves Social and Participation Outcomes for Individuals With Communication Disorders: A Systematic Review
Authors: Boster Jamie B , Spitzley Alyson M , Castle Taylor W , Jewell Abby R , Corso Christina L , McCarthy John W 
Published: September 2020

AbstractThere is increasing interest in exploring the benefits of music in rehabilitation settings. In the field of speech-language pathology, an ultimate goal for individuals with communication disorders is to foster participation across multiple contexts. The goal of this systematic review was to explore social and participation outcomes for individuals with communication disorders who received arts-based interventions. A systematic search of the literature yielded 86 studies, which were coded and summarized in terms of participants, arts-based intervention, social and participation variables, outcome, and quality of evidence. The majority of identified studies (N = 71) utilized music. Results indicated that music-based interventions can improve social and participation outcomes, such as frequency of responses, initiation of communication, turn-taking, joint attention, and group participation for children and adults with autism spectrum disorder and developmental and acquired communication disorders; however, future research is needed to expand the use of varied arts-based interventions targeting a larger breadth of social and participation outcomes.
Simultaneous dysphagia and stridor: an unreported presentation of hypocalcaemia
Authors: Thomas Charlotte , Bhamra Navdeep , Darr Adnan , Amlani Aakash , Murphy John 
Published: September 2020

Abstract
Hypocalcaemia is a well-recognized complication of total thyroidectomy surgery. Patients who develop post-operative hypocalcaemia often report symptoms of neuromuscular instability including peripheral numbness and/or tingling. In severe cases, larygospasm with stridor and bronchospasm can occur. We present the first reported case in the literature, to our knowledge, of a 58-year-old male presenting with intermittent exertional stridor, dysphonia and dysphagia following thyroid surgery 2 years previously. Clinical and radiological investigations were unremarkable. Pre-operative screening for a planned panendoscopy to investigate his symptoms highlighted a profound hypocalcaemia (adjusted calcium 1.42 mmol/l). Following calcium replacement therapy, his symptoms subsided. There is an absence of literature describing both dysphagia and stridor synchronously. We not only advocate regular routine follow-up and compliance assessments for such patients but also the consideration of hypocalcaemia as a differential in any patient presenting with such symptoms following any thyroid surgery.
Alignment of Radio Galaxy Axes using FIRST Catalogue
Authors: Panwar Mohit , Prabhakar Prabhakar , Sandhu Pritpal Kaur , Wadadekar Yogesh , Jain Pankaj 
Published: September 2020

Abstract
We study the alignment of radio galaxies axes using the FIRST catalogue. we impose several cuts in order to select the candidates which are most likely to be free of systematic bias. In our study we primarily focus on testing for alignment among sources within a certain angular separation from one another since for most sources redshift information is not available. We find a very significant effect for angular distances less than 1 degrees. The distance scale of alignment is found to be roughly 28 Mpc, in agreement with earlier estimates, assuming that these sources are dominantly at redshift of 0.8. However, we are not able to entirely rule out the possibility of systematic bias in data. We also perform a full three dimensional analysis using a smaller data sample for which redshift information is available. In this case we only find a very weak signal at much larger distances.
The host galaxies of z = 7 quasars: predictions from the BlueTides simulation
Authors: Marshall Madeline A , Ni Yueying , Di Matteo Tiziana , Wyithe J Stuart B , Wilkins Stephen , Croft Rupert A C , Kuusisto Jussi K 
Published: September 2020

ABSTRACT
We examine the properties of the host galaxies of $z=7$ quasars using the large volume, cosmological hydrodynamical simulation BlueTides. We find that the 10 most massive black holes and the 191 quasars in the simulation (with $M_{\textrm{UV,AGN}}\lt M_{\textrm{UV,host}}$) are hosted by massive galaxies with stellar masses $\log (M_\ast /\, {\rm M}_{\odot })=10.8\pm 0.2$, and $10.2\pm 0.4$, which have large star formation rates of $513_{-351}^{+1225}\, {\rm M}_{\odot }/\rm {yr}$ and $191_{-120}^{+288}\, {\rm M}_{\odot }/\rm {yr}$, respectively. The hosts of the most massive black holes and quasars in BlueTides are generally bulge-dominated, with bulge-to-total mass ratio $B/T\simeq 0.85\pm 0.1$; however, their morphologies are not biased relative to the overall $z=7$ galaxy sample. We find that the hosts of the most massive black holes and quasars are compact, with half-mass radii $R_{0.5}=0.41_{-0.14}^{+0.18}$ kpc and $0.40_{-0.09}^{+0.11}$ kpc, respectively; galaxies with similar masses and luminosities have a wider range of sizes with a larger median value, $R_{0.5}=0.71_{-0.25}^{+0.28}$ kpc. We make mock James Webb Space Telescope (JWST) images of these quasars and their host galaxies. We find that distinguishing the host from the quasar emission will be possible but still challenging with JWST, due to the small sizes of quasar hosts. We find that quasar samples are biased tracers of the intrinsic black hole–stellar mass relation, following a relation that is 0.2 dex higher than that of the full galaxy sample. Finally, we find that the most massive black holes and quasars are more likely to be found in denser environments than the typical $M_{\textrm{BH}}\gt 10^{6.5}\, {\rm M}_{\odot }$ black hole, indicating that minor mergers play at least some role in growing black holes in the early Universe.
The Dark Kinase Knowledgebase: an online compendium of knowledge and experimental results of understudied kinases
Authors: Berginski Matthew E , Moret Nienke , Liu Changchang , Goldfarb Dennis , Sorger Peter K , Gomez Shawn M 
Published: September 2020

AbstractKinases form the backbone of numerous cell signaling pathways, with their dysfunction similarly implicated in multiple pathologies. Further facilitated by their druggability, kinases are a major focus of therapeutic development efforts in diseases such as cancer, infectious disease and autoimmune disorders. While their importance is clear, the role or biological function of nearly one-third of kinases is largely unknown. Here, we describe a data resource, the Dark Kinase Knowledgebase (DKK; https://darkkinome.org), that is specifically focused on providing data and reagents for these understudied kinases to the broader research community. Supported through NIH’s Illuminating the Druggable Genome (IDG) Program, the DKK is focused on data and knowledge generation for 162 poorly studied or ‘dark’ kinases. Types of data provided through the DKK include parallel reaction monitoring (PRM) peptides for quantitative proteomics, protein interactions, NanoBRET reagents, and kinase-specific compounds. Higher-level data is similarly being generated and consolidated such as tissue gene expression profiles and, longer-term, functional relationships derived through perturbation studies. Associated web tools that help investigators interrogate both internal and external data are also provided through the site. As an evolving resource, the DKK seeks to continually support and enhance knowledge on these potentially high-impact druggable targets.
Middle Meningeal Artery Embolization for Chronic Subdural Hematoma: A Multi-Center Experience of 154 Consecutive Embolizations
Authors: Kan Peter , Maragkos Georgios A , Srivatsan Aditya , Srinivasan Visish , Johnson Jeremiah , Burkhardt Jan-Karl , Robinson Timothy M , Salem Mohamed M , Chen Stephen , Riina Howard A , Tanweer Omar , Levy Elad I , Spiotta Alejandro M , Kasab Sami Al , Lena Jonathan , Gross Bradley A , Cherian Jacob , Cawley C Michael , Howard Brian M , Khalessi Alexander A , Pandey Aditya S , Ringer Andrew J , Hanel Ricardo , Ortiz Rafael A , Langer David , Kelly Cory M , Jankowitz Brian T , Ogilvy Christopher S , Moore Justin M , Levitt Michael R , Binning Mandy , Grandhi Ramesh , Siddiq Farhan , Thomas Ajith J 
Published: September 2020

Abstract

BACKGROUND
Middle meningeal artery (MMA) embolization has emerged as a promising treatment for chronic subdural hematoma (cSDH).

OBJECTIVE
To determine the safety and efficacy of MMA embolization.

METHODS
Consecutive patients who underwent MMA embolization for cSDH (primary treatment or recurrence after conventional surgery) at 15 centers were included. Clinical details and follow-up were collected prospectively. Primary clinical and radiographic outcomes were the proportion of patients requiring additional surgical treatment within 90 d after index treatment and proportion with > 50% cSDH thickness reduction on follow-up computed tomography imaging within 90 d. National Institute of Health Stroke Scale and modified Rankin Scale were also clinical outcomes.

RESULTS
A total of 138 patients were included (mean age: 69.8, 29% female). A total of 15 patients underwent bilateral interventions for 154 total embolizations (66.7% primary treatment). At presentation, 30.4% and 23.9% of patients were on antiplatelet and anticoagulation therapy, respectively. Median admission cSDH thickness was 14 mm. A total of 46.1% of embolizations were performed under general anesthesia, and 97.4% of procedures were successfully completed. A total of 70.2% of embolizations used particles, and 25.3% used liquid embolics with no significant outcome difference between embolization materials (P > .05). On last follow-up (mean 94.9 d), median cSDH thickness was 4 mm (71% median thickness reduction). A total of 70.8% of patients had >50% improvement on imaging (31.9% improved clinically), and 9 patients (6.5%) required further cSDH treatment. There were 16 complications with 9 (6.5%) because of continued hematoma expansion. Mortality rate was 4.4%, mostly unrelated to the index procedure but because of underlying comorbidities.

CONCLUSION
MMA embolization may provide a safe and efficacious minimally invasive alternative to conventional surgical techniques.
Treatment of Chronic Granulomatous Disease–Related Pulmonary Aspergillus Infection in Late Pregnancy
Authors: Johnson J A , Pearson J C , Kubiak D W , Dionne B , Little S E , Wesemann D R 
Published: September 2020

AbstractChronic granulomatous disease (CGD) is a primary immunodeficiency syndrome that results in increased risk for bacterial and fungal infections, as well as inflammatory/autoimmune complications. While CGD historically has been associated with early death in childhood, the life expectancy and morbidity of patients with CGD have greatly improved. Many patients with CGD now survive well into adulthood, and data on adult cohorts of patients with CGD have been published. However, reports of pregnancy management, complications, and outcomes for patients with CGD are sparse. In addition, management of invasive fungal infections, including use of newer triazole antifungals, during pregnancy has not been well described. We report a case of fungal lung infection in a pregnant woman with CGD, diagnosed during her second trimester, which was treated with multiple antifungal agents, including more than 12 weeks of isavuconazole therapy, resulting in resolution of infection and delivery of a healthy newborn at term.
Exploration of marine phytoplankton: from their historical appreciation to the omics era
Authors: Karlusich Juan Jose Pierella , Ibarbalz Federico M , Bowler Chris 
Published: September 2020

AbstractMarine phytoplankton are believed to account for more than 45% of photosynthetic net primary production on Earth, and hence are at the base of marine food webs and have an enormous impact on the entire Earth system. Their members are found across many of the major clades of the tree of life, including bacteria (cyanobacteria) and multiple eukaryotic lineages that acquired photosynthesis through the process of endosymbiosis. Our understanding of their distribution in marine ecosystems and their contribution to biogeochemical cycles have increased since they were first described in the 18th century. Here, we review historical milestones in marine phytoplankton research and how their roles were gradually understood, with a particular focus on insights derived from large-scale ocean exploration. We start from the first observations made by explorers and naturalists, review the initial identification of the main phytoplankton groups and the appreciation of their function in the influential Kiel and Plymouth schools that established biological oceanography, to finally outline the contribution of modern large-scale initiatives to understand this fundamental biological component of the ocean.
Colored Pain Drawing as a Clinical Tool in Differentiating Neuropathic Pain from Non-Neuropathic Pain
Authors: Sehgal Nalini , Gordon Debra B , Hetzel Scott , Backonja Miroslav “Misha” 
Published: September 2020

Abstract

Objectives
This is a prospective, blinded, case–control study of patients with chronic pain using body diagrams and colored markers to show the distribution and quality of pain and sensory symptoms (aching, burning, tingling, numbness, and sensitivity to touch) experienced in affected body parts.

Methods
Two pain physicians, blinded to patients’ clinical diagnoses, independently reviewed and classified each colored pain drawing (CPD) for presence of neuropathic pain (NeuP) vs. non-neuropathic pain (NoP). A clinical diagnosis (gold standard) of NeuP was made in 151 of 213 (70.9%) enrolled patients.

Results
CPD assessment at “first glance” by both examiners resulted in correctly categorizing 137 (64.3% by examiner 1) and 156 (73.2% by examiner 2) CPDs. Next, classification of CPDs by both physicians, using predefined criteria of spatial distribution and quality of pain-sensory symptoms, improved concordance to 212 of 213 CPDs (Kappa = 0.99). The diagnostic ability to correctly identify NeuP and NoP by both examiners increased to 171 (80.2%) CPDs, with 80.1% sensitivity and 80.6% specificity (Kappa = 0.56 [95% confidence interval: 0.44–0.68]). The severity scores for pain and sensory symptoms (burning, tingling, numbness, and sensitivity to touch) on the Neuropathic Pain Questionnaire were significantly elevated in NeuP vs. NoP (P &lt; 0.001).

Conclusions
This study demonstrates good performance characteristics of CPDs in identifying patients with NeuP through the use of a simple and easy-to-apply classification scheme. We suggest use of CPDs as a bedside screening tool and as a method for phenotypic profiling of patients by the quality and distribution of pain and sensory symptoms.
Associations between adolescent sleep deficiency and prescription opioid misuse in adulthood
Authors: Groenewald Cornelius B , Law Emily F , Rabbitts Jennifer A , Palermo Tonya M 
Published: September 2020

Abstract

Study objectives
The main aim of this study was to estimate the association between sleep deficiency in adolescence and subsequent prescription opioid misuse in adulthood using United States nationally representative longitudinal data.

Methods
Self-reported data captured in the National Longitudinal Study of Adolescent to Adult Health at baseline (Wave 1; mean age = 16 years) and 12 year follow-up (Wave 4; mean age = 29 years). Participants (n = 12,213) reported on four measures of sleep during adolescence (Wave 1) and on lifetime prescription opioid misuse during adulthood (Wave 4). Associations between adolescent sleep and adult opioid misuse were estimated using multivariate logistic regression analysis controlling for sociodemographics, chronic pain, mental health, childhood adverse events, and a history of substance use.

Results
During adolescence, 59.2% of participants reported sleep deficiency. Prospectively, adolescents reporting not getting enough sleep, chronic unrestful sleep, and insomnia were associated with an increased risk for prescription opioid misuse (adjusted odds ratios [OR] = 1.2, p &lt; 0.005 for all three variables). Short sleep duration was not associated with opioid misuse.

Conclusion
This is the first study to longitudinally link sleep deficiency as an independent risk factor for the development of prescription opioid misuse. Sleep deficiency could be a driver of the opioid crisis affecting young people in the United States. Future studies should determine whether early and targeted sleep interventions may decrease risk for opioid misuse in high-risk patients prescribed opioids for pain.
Limiting the fiduciary’s account of profits: but-for causation?
Authors: Yeung Alex C H , Fee Jason 
Published: September 2020

Abstract
In an account of profits for breach of fiduciary duty, courts have understandably required some form of nexus between the breach and the gains to be disgorged, but have otherwise struggled to articulate a precise test. In the recent case of UVJ v UVH, the Singapore Court of Appeal broke new ground by requiring but-for causation, apparently branching off from the Anglo-Australian jurisprudence which advocates a more liberal approach to causation. While the but-for test is practically appealing as a technique well known to various areas of law, this article seeks to assess the normative justifications for such a bold move, in view of the attendant issues of deterrence, the unique policy of fiduciary law, and the juridical nature of an account of profits.
A Child Infected with COVID-19 in China—A Case Report
Authors: Lin Chunxia , Zhong Beilong , Zheng Fangfang , Guo Xinming , Guo Yi , Deng Zhizhong , Zhou Chuanxin , Guo Yangbin 
Published: September 2020

Abstract
A 16-month-old boy was admitted with cough for 2 days and fever for 1 day. Chest computed tomography (CT) scan of the child revealed large areas of ground-glass opacities in both lungs. Nucleic acid amplification tests (NAATs) were performed repeatedly to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the results were all negative. On day 13 of hospitalization, no clinical symptoms except diarrhea were present in the patient, and re-examination by chest CT revealed lesion shrinkage, but the NAAT on throat swabs was positive. On day 22 of hospitalization, the NAAT on throat swabs was negative and the fecal samples were positive. Positive fecal samples nucleic acid lasted for 62 days. Suggesting that pediatric patients may be important sources of infection during the recovery phase of clinical symptoms and whether SARS-CoV-2 has fecal–oral transmission needs further study.