bluuebunny/crossref_metadata_2025_split huggingface dataset:
Solvability of a class of hyperbolic-cosine-type difference equations
Authors: Stević Stevo , Iričanin Bratislav , Kosmala Witold , Šmarda Zdeněk 
Published: October 2020

AbstractWe describe a method for constructing one of the basic classes of solvable hyperbolic-cosine-type difference equations, generalizing a known difference equation by Laplace in a natural way.
Does weight-for-height and mid upper-arm circumference diagnose the same children as wasted? An analysis using survey data from 2017 to 2019 in Mozambique
Authors: Zaba Tomás , Nyawo Mara , Álvarez Morán Jose Luis 
Published: October 2020

Abstract
Background
Three different diagnostic criteria are used to identify children aged 6 to 59 months with acute malnutrition: weight-for-height (WHZ), middle upper arm circumference (MUAC) and bilateral pitting oedema. Prevalence of malnutrition from surveys is among the most-used decision support data, however not all diagnostic criteria are used to calculate need, creating a mismatch between programme planning and implementation. With this paper, we investigate if such discrepancies are observed in Mozambique.

Methods
Population-based nutritional anthropometric surveys from 45 districts in Mozambique conducted by the Technical Secretariat for Food Security and Nutrition (SETSAN) and UNICEF between 2017 and 2019 were analysed. We used Cohen’s kappa coefficient to measure inter-rater agreement between WHZ and MUAC, Spearman’s rank-order coefficient to assess the correlation, binary logistic regression to investigate factors influencing WHZ and MUAC diagnostic classification. We compared acute malnutrition caseload estimates by WHZ, MUAC and oedema to caseloads from combined prevalence estimates.

Results
WHZ and MUAC rarely agree on their diagnostic classification (κ = 0.353, ρ < 0.001) and results did not vary by province. We found positive correlation between WHZ and MUAC (rho = 0.593, ρ < 0.0001). Binary logistic regression explained 3.1% of variation in WHZ and 12.3% in the MUAC model. Girls (AOR = 1.6, ρ < 0.0001), children < 24 months (AOR = 5.3, ρ < 0.0001) and stunted children (AOR = 3.5, ρ < 0.0001) influenced the MUAC classification. In the WHZ model, children < 24 months (AOR = 2.4, ρ < 0.0001) and stunted children (AOR = 1.7, ρ < 0.0001) influenced the classification, sex had no effect. Caseload calculations of global acute malnutrition by WHZ and/oedema-only and by MUAC and/oedema-only yielded less children than caseload calculations using the combined prevalence estimates. Similarly, caseload calculations for SAM by WHZ and/oedema-only and SAM by MUAC and/oedema-only yielded less children than the respective combined prevalence calculations.

Conclusions
Given the discrepancy in diagnostic classification between WHZ and MUAC in Mozambique, using either one alone for calculating burden underestimates the real number of children in need of treatment and negatively affects nutrition programme planning. We recommend that use of the combined prevalence estimates, based on the three diagnostic criteria of WHZ, MUAC and oedema, be officially adopted. Further analysis is needed to detail the programmatic impact of this change.
Lost in space - an exploration of help-seeking among young people with mental health problems: a constructivist grounded theory study
Authors: Westberg Katrin Häggström , Nygren Jens M. , Nyholm Maria , Carlsson Ing-Marie , Svedberg Petra 
Published: October 2020

Abstract
Background
Mental health problems among young people is a worldwide public health concern. There has been an increase in mental health problems among young people in the Nordic countries in the last 25 years, particularly in Sweden. Despite this increase, international research has repeatedly shown that young people do not access or receive support when encountering mental health problems. The purpose of this study was to explore the process of help-seeking for professional support among young people with mental health problems.

Methods
The study used qualitative constructivist Grounded Theory and open-ended interviews. Thirteen young people between 15 and 23, recruited from two local support clinics, were interviewed.

Results
Lost in space emerged as the core category, capturing aspects of both the experience of self and mental health problems as well as the process of seeking and acquiring help from professional support systems. The study identified several prominent barriers for seeking and acquiring professional help for mental health problems. The young people expressed a lack of knowledge on mental health issues and support services and substantial efforts were made to try to cope with problems on one’s own. Lost in space involved Drifting - trying to make sense of own experiences and struggling to cope with problems, Navigating - searching for help through multiple attempts and contacts and Docking - finding support with something/somebody that feels right.

Conclusions
The theoretical model sheds light on how young people with mental health problems were met with fragmented support services. Society needs to provide encompassing, youth-friendly and flexible support services, so that attempts at help-seeking are not missed.
Accessibility of urban green infrastructure in Addis-Ababa city, Ethiopia: current status and future challenge
Authors: Azagew Sileshi , Worku Hailu 
Published: October 2020

AbstractMany studies have been conducted on the challenges underpinning the depletion and inaccessibility of urban green infrastructures (UGI) in cities of developed countries. Contrary to this, similar studies in rapidly urbanizing cities of Africa are scant. In this study, we assessed the status, accessibility and constraints of UGI in rapidly urbanizing city Addis Ababa, Ethiopia. We first mapped and calculated the status of UGI from 2003 to 2016 based on the land use data in Arch GIS. We then analyzed UGI access such as recreational parks based on proximate and per capita green indicators by using the land use maps, road network and gridded population data. Finally, we examined the challenges behind the current states of UGI based on document review, expert interview and field observation. Our study disclosed that the land use of UGI from 2003 to 2016 is decreased by 9.2%. The land use of urban agriculture decreased significantly (by 11.9%) followed by urban forest (by 3.7%). The accessibility indicators also revealed that the city residents have no sufficient recreational UGI. The city’s park per capita was very small (0.37 m2) compared to Ethiopian UGI standards (15 m2) and the large portion of the city’s population (above 90%) has no access to existing parks within the minimum walking distance thresholds. Expansion of built up environment, density, weak implementation of policies and plans, and lack of priority for UGI development were identified as the major constraints behind the current state of UGI in the city. We conclude that UGI is degrading and insufficiently accessible for the city residents due to weak enforcement of development plans, density, built up area expansion, and lack of priority for UGI. Thus, strict adherence to the development plans and regulations is of paramount importance to maintain UGI in the city. Moreover, developing small to median size parks in already proposed areas, new expansion and renewal parts of the city is vital to enhance recreational park access. We hope that this study serves as a benchmark for policy and planning to ensure accessible and adequate UGI in rapidly urbanizing city Addis Ababa and beyond.
Unsupervised identification of crime problems from police free-text data
Authors: Birks Daniel , Coleman Alex , Jackson David 
Published: October 2020

AbstractWe present a novel exploratory application of unsupervised machine-learning methods to identify clusters of specific crime problems from unstructured modus operandi free-text data within a single administrative crime classification. To illustrate our proposed approach, we analyse police recorded free-text narrative descriptions of residential burglaries occurring over a two-year period in a major metropolitan area of the UK. Results of our analyses demonstrate that topic modelling algorithms are capable of clustering substantively different burglary problems without prior knowledge of such groupings. Subsequently, we describe a prototype dashboard that allows replication of our analytical workflow and could be applied to support operational decision making in the identification of specific crime problems. This approach to grouping distinct types of offences within existing offence categories, we argue, has the potential to support crime analysts in proactively analysing large volumes of modus operandi free-text data—with the ultimate aims of developing a greater understanding of crime problems and supporting the design of tailored crime reduction interventions.
Seismic velocity structure at the southern termination of the 2016 Kumamoto Earthquake rupture, Japan
Authors: Aoyagi Yasuhira , Kimura Haruo , Mizoguchi Kazuo 
Published: October 2020

AbstractThe earthquake rupture termination mechanism and size of the ruptured area are crucial parameters for earthquake magnitude estimations and seismic hazard assessments. The 2016 Mw 7.0 Kumamoto Earthquake, central Kyushu, Japan, ruptured a 34-km-long area along previously recognized active faults, eastern part of the Futagawa fault zone and northernmost part of the Hinagu fault zone. Many researchers have suggested that a magma chamber under Aso Volcano terminated the eastward rupture. However, the termination mechanism of the southward rupture has remained unclear. Here, we conduct a local seismic tomographic inversion using a dense temporary seismic network to detail the seismic velocity structure around the southern termination of the rupture. The compressional-wave velocity (Vp) results and compressional- to shear-wave velocity (Vp/Vs) structure indicate several E–W- and ENE–WSW-trending zonal anomalies in the upper to middle crust. These zonal anomalies may reflect regional geological structures that follow the same trends as the Oita–Kumamoto Tectonic Line and Usuki–Yatsushiro Tectonic Line. While the 2016 Kumamoto Earthquake rupture mainly propagated through a low-Vp/Vs area (1.62–1.74) along the Hinagu fault zone, the southern termination of the earthquake at the focal depth of the mainshock is adjacent to a 3-km-diameter high-Vp/Vs body. There is a rapid 5-km step in the depth of the seismogenic layer across the E–W-trending velocity boundary between the low- and high-Vp/Vs areas that corresponds well with the Rokkoku Tectonic Line; this geological boundary is the likely cause of the dislocation of the seismogenic layer because it is intruded by serpentinite veins. A possible factor in the southern rupture termination of the 2016 Kumamoto Earthquake is the existence of a high-Vp/Vs body in the direction of southern rupture propagation. The provided details of this inhomogeneous barrier, which are inferred from the seismic velocity structures, may improve future seismic hazard assessments for a complex fault system composed of multiple segments.
Family impact and economic burden among caregivers of children with chronic kidney disease in Assiut, Egypt
Authors: Darwish Manal M , Hassan Shimaa Hosny , Taha Samaher Fathy , Abd El-Megeed Hosnia Said , Ismail Taghreed Abdul-Aziz Mohammad 
Published: October 2020

Abstract
Background
Chronic disease greatly increases children’s dependency on parents/caregivers (usually mothers) as they face new problems associated with caring for a child with chronic disease. Thus, chronic kidney disease (CKD) presents a burden for children and their families that last throughout life in different aspects. This study aimed to assess family impact and economic burden of chronic kidney disease (CKD) in children on their families.

Methods
A cross-sectional study was carried out on 250 caregivers of children with CKD attending tertiary care hospital/health insurance clinics in Assiut, Egypt using PedsQL™ family impact module (FIM) for assessing family impact and economic burden between January and May 2018.

Results
Seventy six percent of caregivers shared paying for treatment with health insurance while 14% paid the total expenses out of their pockets. Although the majority (87.2%) of caregivers suffered different degrees of financial hardship, more than 60% of them had no coping strategy. The regression module showed that responding caregiver, degree of financial hardship, treatment modality, and socioeconomic class were significant predictors of total FIM (β = 0.38, P < 0.001; β = 0.28, P < 0.001; β = 0.22, P < 0.001; β = 0.13, P = 0.006 respectively).

Conclusion
Most caregivers were involved in paying for treatment of their children either totally or sharing with health insurance and suffered different degrees of financial hardship. Mothers, caregivers with great financial hardship, and caregivers of children on dialysis had the lowest scores of PedsQL™ FIM. There is a high need for expansion of health insurance umbrella to reduce financial hardship together with continued multidimensional support to families.
Massive gastric necrosis associated with delayed presentation of congenital diaphragmatic hernia—is salvage possible?
Authors: Krishna Kumar G. , Mallikarjun U. , Reshma D. 
Published: October 2020

Abstract
Background
Delayed presentation of congenital diaphragmatic hernia is an uncommon event. Occurrence of gastric volvulus with massive necrosis in this setting is unusual. In this difficult scenario, the surgeon is faced with the dilemma of conservation or resection.

Case presentation
A 1-year-old boy with vague gastrointestinal symptoms was found to have congenital diaphragmatic hernia with gastric volvulus, on imaging. The stomach showed massive necrosis secondary to volvulus, and after removal of the necrotic body of the stomach, the remnant was sutured together.

Conclusion
Congenital diaphragmatic hernia is difficult to diagnose in late presenters beyond the neonatal period due to lack of respiratory symptoms. Stomach salvage is feasible even in severe vascular compromise due to extensive collaterals.
Prospective Cohort Study of Pre- and Postdiagnosis Physical Activity and Endometrial Cancer Survival
Authors: Friedenreich Christine M. , Cook Linda S. , Wang Qinggang , Kokts-Porietis Renée L. , McNeil Jessica , Ryder-Burbidge Charlotte , Courneya Kerry S. 
Published: October 2020

PURPOSE The aim of this study was to evaluate associations between pre- and postdiagnosis physical activity and survival in survivors of endometrial cancer by physical activity domain, intensity, dose (metabolic-equivalent task [MET]-hours/week/year), and change from pre- to postdiagnosis. METHODS We conducted a prospective cohort study in Alberta, Canada, of 425 women who were diagnosed with histologically confirmed invasive endometrial cancer between 2002 and 2006 and observed to 2019. The interviewer-administered Lifetime Total Physical Activity Questionnaire recorded prediagnosis (assessed at a median of 4.4 months after diagnosis) and postdiagnosis physical activity (assessed at a median of 3.4 years after diagnosis). Associations between physical activity and overall and disease-free survival were assessed using Cox proportional hazards models adjusted for age, stage, grade, treatments, body mass index, menopausal status, hormone therapy use, family history of cancer, and comorbidities. RESULTS After a median follow-up of 14.5 years, there were 60 deaths, including 18 endometrial cancer deaths, and 80 disease-free survival events. Higher prediagnosis recreational physical activity was statistically significantly associated with improved disease-free survival (> 14 v ≤ 8 MET-hours/week/year; hazard ratio [HR], 0.54; 95% CI, 0.30 to 0.96; Ptrend = .04), but not overall survival (HR, 0.56; 95% CI, 0.29 to 1.07; Ptrend = .06). Higher postdiagnosis recreational physical activity (> 13 v ≤ 5 MET-hours/week/year) was strongly associated with both improved disease-free survival (HR, 0.33; 95% CI, 0.17 to 0.64; Ptrend = .001) and overall survival (HR, 0.33; 95% CI, 0.15 to 0.75; Ptrend = .007). Participants who maintained high recreational physical activity levels from pre- to postdiagnosis also had improved disease-free survival (HR, 0.35; 95% CI, 0.18 to 0.69) and overall survival (HR, 0.43; 95% CI, 0.20 to 0.94) compared with those who maintained low physical activity levels. CONCLUSION Recreational physical activity, especially postdiagnosis, is associated with improved survival in survivors of endometrial cancer.
Acute Ketogenic Diet and Ketone Ester Supplementation Impairs Race Walk Performance
Authors: WHITFIELD JAMIE , BURKE LOUISE M. , MCKAY ALANNAH K. A. , HEIKURA IDA A. , HALL REBECCA , FENSHAM NIKITA , SHARMA AVISH P. 
Published: October 2020

ABSTRACT
The consumption of a ketogenic low-carbohydrate (CHO), high-fat (LCHF) diet increases skeletal muscle fat utilization but impairs exercise economy. Whether the concomitant increase in circulating endogenous ketone bodies (KB) alters the capacity to metabolize exogenous ketone supplements such as the popular ketone monoester is unknown.

Purpose
This study aimed to determine if LCHF and ketone ester (KE) supplementation can synergistically alter exercise metabolism and improve performance.

Methods
Elite race walkers (n = 18, 15 males and 3 females; V˙O2peak, 62 ± 6 mL·min−1·kg−1) undertook a four-stage exercise economy test and real-life 10,000-m race before and after a 5-d isoenergetic high-CHO (HCHO, ~60%–65% fat; CHO, 20% fat; n = 9) or LCHF (75%–80% fat, <50 g·d−1 CHO, n = 9) diet. The LCHF group performed additional economy tests before and after diet after supplementation with 573 mg·kg−1 body mass KE (HVMN; HVMN Inc., San Francisco, CA), which was also consumed for race 2.

Results
The oxygen cost of exercise (relative V˙O2, mL·min−1·kg−1) increased across all four stages after LCHF (P < 0.005). This occurred in association with increased fat oxidation rates, with a reciprocal decrease in CHO oxidation (P < 0.001). Substrate utilization in the HCHO group remained unaltered. The consumption of KE before the LCHF diet increased circulating KB (P < 0.05), peaking at 3.2 ± 0.6 mM, but did not alter V˙O2 or RER. LCHF diet elevated resting circulating KB (0.3 ± 0.1 vs 0.1 ± 0.1 mM), but concentrations after supplementation did not differ from the earlier ketone trial. Critically, race performance was impaired by ~6% (P < 0.0001) relative to baseline in the LCHF group but was unaltered in HCHO.

Conclusion
Despite elevating endogenous KB production, an LCHF diet does not augment the metabolic responses to KE supplementation and negatively affects race performance.
Gene editing in dermatology: Harnessing CRISPR for the treatment of cutaneous disease
Authors: Baker Catherine , Hayden Matthew S. 
Published: October 2020

The discovery of the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) system has revolutionized gene editing research. Through the repurposing of programmable RNA-guided CRISPR-associated (Cas) nucleases, CRISPR-based genome editing systems allow for the precise modification of specific sites in the human genome and inspire novel approaches for the study and treatment of inherited and acquired human diseases. Here, we review how CRISPR technologies have stimulated key advances in dermatologic research. We discuss the role of CRISPR in genome editing for cutaneous disease and highlight studies on the use of CRISPR-Cas technologies for genodermatoses, cutaneous viruses and bacteria, and melanoma. Additionally, we examine key limitations of current CRISPR technologies, including the challenges these limitations pose for the widespread therapeutic application of CRISPR-based therapeutics.
Are Inventors or Firms the Engines of Innovation?
Authors: Bhaskarabhatla Ajay , Cabral Luis , Hegde Deepak , Peeters Thomas 
Published: October 2020

In this study, we empirically assess the contributions of inventors and firms for innovation using a 37-year panel of U.S. patenting activity. We estimate that inventors’ human capital is 5–10 times more important than firm capabilities for explaining the variance in inventor output. We then examine matching between inventors and firms and find highly talented inventors are attracted to firms that (i) have weak firm-specific invention capabilities and (ii) employ other talented inventors. A theoretical model that incorporates worker preferences for inventive output rationalizes our empirical findings of negative assortative matching between inventors and firms and positive assortative matching among inventors. This paper was accepted by Ashish Arora, entrepreneurship and innovation.
Gatekeeping, Fast and Slow: An Empirical Study of Referral Errors in the Emergency Department
Authors: Freeman Michael , Robinson Susan , Scholtes Stefan 
Published: October 2020

Using data from over 300,000 visits to an emergency department (ED), we study the accuracy of gatekeeping decisions—the choices that physicians make regarding patient discharge or admission to the hospital. In our study context, we focus specifically on the effectiveness of a second gatekeeping stage in the ED—a clinical decision unit (CDU). Although only 9.9% of patients in our sample are routed through the CDU, we find that had the unit not been in place during the observation period, the rates of unnecessary hospitalization and wrongful patient discharge from the ED would have increased by 14.3% and 29.6%, respectively. We also find that the CDU is especially beneficial for patients with a high ex ante risk of experiencing unnecessary hospitalization, with the rate for the most high-risk patients reduced from 14.0% without the CDU to just 4.8% had all such patients been routed through the CDU. The appropriateness of referrals is therefore a key contributor to the CDU’s effectiveness: We estimate that random allocation of patients in our study hospital to the CDU would have reduced the unit’s effectiveness by more than half. Finally, we investigate a critical trade-off in designing a two-stage gatekeeping system: Resources must be split between the two stages, increasing congestion in the first stage when the second stage is enlarged. We demonstrate that in the study hospital, the combination of an ED and CDU performs better than a pooled system that combines the capacity of both stages to enlarge the ED but does not have a designated CDU. In fact, we estimate that in this specific case, reducing the size of the first-stage ED in order to expand CDU capacity from the current 9.9% of ED patients to 25% would further reduce unnecessary hospitalizations by up to 33%. We discuss the insights that these results provide as to the circumstances under which it may be advantageous to add a second stage to a gatekeeping system. This paper was accepted by David Simchi-Levi, operations management.