bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indol-2-Carboxylic Acid Esters Containing N-Phenylpiperazine Moiety - Preparation and Cholinesterase-inhibiting Activity
Authors: Padrtová Tereza , Marvanová Pavlína , Kubínová Renáta , Csöllei Jozef , Farsa Oldřich , Goněc Tomáš , Odehnalová Klára , Opatřilová Radka , Pazourek Jiří , Sychrová Alice , Šmejkal Karel , Mokrý Petr 
Published: June 2020

Background:
The indole derivatives and the N-phenylpiperazine fragment represent interesting
molecular moieties suitable for the research of new potentially biologically active compounds. This study was
undertaken to identify if indol-2-carboxylic acid esters containing N-phenylpiperazine moiety possess
acetylcholinesterase and butyrylcholinesterase inhibitory activity.

Materials and Methods:
The study dealt with the synthesis of a novel series of analogs of 1H-indole-2-
carboxylic acid and 3-methyl-1H-indole-2-carboxylic acid. The structure of the derivatives was represented by
the indolylcarbonyloxyaminopropanol skeleton with the attached N-phenylpiperazine or diethylamine moiety,
which formed a basic part of the molecule. The final products were synthesized as dihydrochloride salts, fumaric
acid salts, and quaternary ammonium salts. The first step of the synthetic pathway led to the preparation of esters
of 1H-indole-2-carboxylic acid from the commercially available 1H-indole-2-carboxylic acid. The Fischer indole
synthesis was used to synthesize derivatives of 3-methyl-1H-indole-2-carboxylic acid.

Results and Discussion:
Final 18 indolylcarbonyloxyaminopropanols in the form of dihydrochlorides, fumarates,
and quaternary ammonium salts were prepared using various optimization ways. The very efficient way for the
formation of 3-methyl-1H-indole-2-carboxylate (Fischer indole cyclization product) was the one-pot synthesis of
phenylhydrazine with methyl 2-oxobutanoate with acetic acid and sulphuric acid as catalysts.

Conclusion:
Most of the derivatives comprised of an attached N-phenylpiperazine group, which formed a basic
part of the molecule and in which the phenyl ring was substituted in position C-2 or C-4. The synthesized
compounds were subjected to cholinesterase-inhibiting activity evaluation, by modified Ellman method.
Quaternary ammonium salt of 1H-indole-2-carboxylic acid which contain N-phenylpiperazine fragment with
nitro group in position C-4 (7c) demonstrated the most potent activity against acetylcholinesterase.
Electrochemical Oxidative Esterification of Thiophenols: Efficient Access to Sulfinic Esters
Authors: Yang Chun-Hui , Wu Cheng , Zhang Jun-Ming , Tao Xiang-Zhang , Xu Jun , Dai Jian-Jun , Xu Hua-Jian 
Published: June 2020

Background:
The sulfinic esters are important and useful building blocks in organic synthesis.

Objective:
The aim of this study was to develop a simple and efficient method for the synthesis of sulfinic esters.

Materials and Methods:
Constant current electrolysis from thiols and alcohols was selected as the method for the
synthesis of sulfinic esters.

Results and Discussion:
A novel electrochemical method for the synthesis of sulfinic esters from thiophenols and
alcohols has been developed. Up to 27 examples of sulfinic esters have been synthesized using the current methods.
This protocol shows good functional group tolerance as well as high efficiency. In addition, this protocol can be easily
scaled up with good efficiency. Notably, heterocycle-containing substrates, including pyridine, thiophene, and
benzothiazole, gave the desired products in good yields. A plausible reaction mechanism is proposed.

Conclusion:
This research not only provides a green and efficient method for the synthesis of sulfinic esters but
also shows new applications of electrochemistry in organic synthesis. It is considered that this green and efficient
synthetic protocol used to prepare sulfinic esters will have good applications in the future.
Telematics Healthcare Through Digital Terrestrial Television Networks: Applications and Perspectives
Authors: Kardaras Konstantinos , Lambrou George I. , Koutsouris Dimitrios 
Published: June 2020

Background:
The trend nowadays is the interconnection of rural health centers with a specialized
monitoring medical center.

Aim:
The paper investigates the qualitative and quantitative characteristics that degrade the perceived video
picture quality for a variety of short MPEG-4 video clips.

Methods:
In the present work our approach was considered in three branches; first the customization of video
quality in terms of video and data compression, so maximum quality is achieved, second the use of the optimized
video data transfer for emergency situations and third the subsequent creation of a “virtual doctor”.

Results:
Further on, novel architectures will be suggested in order to achieve the creation of a broadcasting
network for healthcare telematics. Remote medical supervision and healthcare treatment will be provided to
remote patients in rural health centers and understaffed areas that lack telemetry infrastructures and medical
expertise personnel.

Conclusions:
The proposed architecture, along with the optimized data transmission, demonstrates the
integration of present and forthcoming telecommunication network technologies enabling remote interactivity
for fixed, portable and mobile users.
Molecular Docking, Physicochemical Properties, Pharmacokinetics and Toxicity of Flavonoids Present in Euterpe oleracea Martius
Authors: de Oliveira Nayana Keyla Seabra , Almeida Marcos Rafael Silva , Pontes Franco Márcio Maciel , Barcelos Mariana Pegrucci , Silva Guilherme Martins , de Paula da Silva Carlos Henrique Tomich , Cruz Rodrigo Alves Soares , da Silva Hage-Melim Lorane Izabel 
Published: June 2020

Background:
Euterpe oleracea Martius, popularly known as açaí, is a fruit rich in α-
tocopherols, fibers, lipids, mineral ions, and polyphenols. It is believed that the high content of polyphenols,
especially flavonoids, provides several health-promoting effects to the açaí fruit, including
anti-inflammatory, immunomodulatory, antinociceptive and antioxidant properties. Most of the
flavonoids are antioxidant molecules of plant origin that act as a trap for free radicals, reacting and
neutralizing them, thus offering perspectives in preventing oxidative damage.

Objective:
In this study, we aim to perform an in silico evaluation of flavonoids present in the pulp
and the oil of Euterpe oleracea Martius, evaluating their potential to serve as antioxidant agents.

Methods:
Firstly, we selected 16 flavonoids present in Euterpe oleracea Martius pulp and oil, and
then their physicochemical properties were analyzed concerning the Lipinski’s Rule of Five. Moreover,
we evaluated their pharmacokinetic properties using the QikProp module of the Schrödinger
software as well as their toxicity profile, using the DEREK software. Docking simulations, using
the GOLD 4.1 software, as well as pharmacophoric hypotheses calculation of molecules were also
performed.

Results:
Flavonoids present in the açaí pulp including catechin, epicatechin, luteolin, chrisoeriol,
taxifolin, apigenin, dihydrokaempferol, isovitexin, and vitexin presented good oral bioavailability.
Regarding the pharmacokinetic properties, the compounds catechin, epicatechin, isovitexin, luteolin,
chrisoeriol, taxifolin, and isorhamnetin rutinoside presented the best results, besides high human
oral absorption. Regarding the prediction of toxicological properties, compounds isorhamnetin
rutinoside and rutin presented mutagenicity for hydroxynaphthalene or derivate, and regarding the
docking simulations, all the compounds investigated in this study presented key interactions with
the corresponding targets.

Conclusion:
The flavonoids catechin, chrysoeriol, and taxifolin presented the best results according
to the evaluation conducted in this study. These computational results can be used as a theoretical
basis for future studies concerning the development of drug candidates, as well as to enlighten biological
tests in vitro and in vivo, which can contribute to the treatment of neurodegenerative diseases,
such as Alzheimer's disease, Parkinson's disease, and Huntington's disease.
Development and Validation of a Robust HPLC Method for Simultaneous Estimation of 5-Fluorouracil and Resveratrol and its Application in the Engineered Nanostructured Lipid Carrier
Authors: Iqubal Mohammad Kashif , Kamal Abid , Iqubal Ashif , Imran Mohammad , Ali Javed , Baboota Sanjula 
Published: June 2020

Background:
5-fluorouracil and resveratrol are the two most effective anticancer drugs.
Combination therapy with these two drugs has shown promising results in cancer. The formulation
containing 5-fluorouracil and resveratrol has been prepared, but no analytical method is available in
the literature for their simultaneous estimation. However, several analytical methods are there for estimation
of either 5-fluorouracil or resveratrol alone. Therefore, the present article is designed for the
simultaneous estimation of 5-fluorouracil and resveratrol by HPLC and its application in the quantification
of the drugs present in the formulated nanostructured lipid carrier (NLC).

Methods:
The method was developed using a C18 column (Purospher® STAR RP-18 endcapped (5
μm) Hibar® RT 250-4.6) with acetonitrile and water as the mobile phase (25:75 v/v) and estimated at
272 nm. The currently developed method was further validated by the ICH guideline Q2 (R1). Combinatorial
NLC of 5-fluorouracil and resveratrol was also prepared and characterized.

Results:
The LOD and LOQ were 8.22 and 24.91 μg mL-1 and 6.58 and 19.93 μg mL-1, respectively.
The precision was under the acceptable limits of <2% RSD. The content of 5-fluorouracil and
resveratrol in NLC were found to be 99.452% and 96.421%, respectively.

Conclusion:
The findings showed that the developed and validated method was simple, fast, costeffective,
and reproducible for the simultaneous estimation of both the drugs in the same formulation.
Antigene and Antiproliferative Effects of Triplex-Forming Oligonucleotide (TFO) Targeted on hmgb1 Gene in Human Hepatoma Cells
Authors: Lohani Neelam , Rajeswari Moganty R. 
Published: June 2020

Background:
The high mobility group box 1 (hmgb1) is one of the frequently over-expressed genes
whose aberrant expression is reported in a number of human cancers. Various strategies are underway to inhibit
hmgb1 expression in cancer cells having considerable therapeutic value.

Objective:
The present work involves selective transcriptional inhibition of the hmgb1 gene using selective DNA
triplex structure-based gene technology. Here, the promoter region of the hmgb1 gene at position (-183 to -165) from
the transcription start site as a target was selected using bioinformatic tools.

Methods:
The DNA triplex formation by the DNA of the target gene and TFO was confirmed using UV absorption
spectroscopy, Circular Dichroism, and Isothermal Calorimetry.

Results:
Treatment of HepG2 cell with specific Triplex-forming Oligonucleotide significantly downregulated
HMGB1 expression level at mRNA and protein levels by 50%, while the classical anticancer drugs, actinomycin/
adriamycin as positive controls showed 65% and the combination of TFO and drug decreased by 70%. The
anti-proliferative effects of TFO correlated well with the fact of accumulation of cells in the Go phase and apoptotic
cell death. Further, the binding of anti-cancer drugs to hmgb1 is stronger in DNA triplex state as compared
to hmgb1 alone, suggesting the combination therapy as a better option.

Conclusion:
Therefore, the ability of hmgb1 targeted triplex-forming oligonucleotide in combination with triplex
selective anticancer drug holds promise in the treatment of malignancies associated with hmgb1 overexpression.
The result obtained may open up new vistas to provide a basis for the rational drug design and searching
for high-affinity ligands with a high triplex selectivity.
Co-Existence of Sarcoidosis and Sjögren’s Syndrome with Hypercalcemia and Renal Involvement: A Case Report and Literature Review
Authors: Xu Jing , Yang Yumei , Chen Dandan , Lu Zhiqiang , Ge Junbo , Li Xiaomu , Gao Xin 
Published: June 2020

Background:
Sarcoidosis and Sjögren's syndrome (SS) are chronic multi-system
inflammatory diseases of unknown origin that most commonly attack the salivary glands. Both of the
diseases have vague and non-specific symptoms, causing difficulties for the clinicians to distinguish
between the two diseases. Main diagnostic criteria of SS exclude sarcoidosis. However, a co-existence
of both diseases should be noted. Here, a case of co-existing sarcoidosis and Sjögren's syndrome is
reported, complicated with severe hypercalcemia and renal failure, in addition to a literature review.

Case Report:
A 71-year-old man visited our hospital complaining of daily progressive oral dryness,
thirst, and blurred vision with a feeling of dry eyes for a one-year duration. His physical examination
showed enlargement of both sides of cervical and supraclavicular lymph nodes. Lung auscultation
showed decreased breath sounds with bibasilar inspiratory crackles. However, initial laboratory results
revealed severe hypercalcemia with moderate hypercalciuria and renal failure. The final diagnosis was
co-existing SS and sarcoidosis according to clinical, radiological, and laboratory data. The patient received
oral prednisone therapy for 18 months. After a follow-up of years, the serum calcium concentration,
renal function, and chest CT scan remained normal after prednisone treatment stopped for more
than 18 months.

Conclusion:
In the literature, calcium metabolic disorder and renal involvement have not been reported among patients with Sarcoidosis and Sjögren's syndrome, suggesting that calcium metabolic
disorder may be underestimated. Serum and urine calcium concentration should be measured in addition to routine laboratory tests.
A Review on Expedient Assets of Polymers Employed in Novel Topical Formulation for Successful Treatment of Arthritis
Authors: Nishal Suchitra , Jhawat Vikas , Phaugat Parmita 
Published: June 2020

Background:
Rheumatoid arthritis (RA) is an autoimmune ailment where the body's defense
system is violated by damaging its joints. In RA treatment strategies, attempts have been
made for oral, topical, and parenteral formulations with different drugs, but none of the formulations
could be regarded as the perfect dosage form. In the current review, the meticulous discussion
has been made on the suitability of novel topical formulations in the treatment of RA. Moreover,
the emphasis has been made on activities of biodegradable polymers such as hyaluronic acid,
lecithin, pluronic acid, chitosan, human serum albumin (HSA), and polylactide glycolic acid (PLGA)
as well as their role in the management of RA.

Objective:
The study aimed to apprehend the role of polymeric materials in developing an ideal topical
drug delivery system that can bestow targeted delivery, enhanced penetration of drugs, improved
stability of the formulation, and improved PKPD profile of the drugs.

:
These polymers possess twofold functions, primarily by increasing skin penetration and secondarily
by improving joint mobility and cartilage regeneration. Furthermore, biocompatibility and
biodegradability are features that increase the use of the aforementioned polymers.

Results:
The significant role of all the polymers in improving the conditions of bones and joints
suffering from rheumatoid arthritis has been demonstrated by various studies.
Retos epistemológicos del Trabajo Social: indicios de alternativas al paradigma moderno de bienestar social
Authors: Guzmán Cáceres Maricela , Carrillo Gómez Karla Patricipa , Vázquez Sánchez Idalia 
Published: June 2020

En el marco de la sociedad postindustrial y la reconfiguración del Estado de Bienestar, el Trabajo Social como disciplina y práctica científica encara los retos de mediatizar las relaciones entre el Estado, el mercado y la sociedad. Ello amerita repasar los fundamentos epistemológicos de esta disciplina, de ahí que el objetivo principal del artículo sea reflexionar respecto a sus especificidades en el marco del paradigma interdisciplinario y la división sociotécnica del trabajo. Se siguió un método sintético bajo un paradigma constructivista y se emplearon recursos bibliográficos. Se argumenta que la teorización en Trabajo Social es una necesidad ante la búsqueda de asideros existenciales para afrontar la falta de certezas derivada de la crisis de los metarrelatos de la modernidad y las contradicciones internas del Estado de Bienestar. Se concluye que el Trabajo Social como disciplina encuentra una veta potencial en la indagación de epistemologías alternativas al paradigma occidental, en particular aquellas vinculadas al buen vivir, en tanto que complementan la búsqueda de bienestar y calidad de vida ligadas al ejercicio de intervención del trabajo social, en función de su vocación emancipadora.
Evolución y estado actual de la ciencia y la tecnología en República Dominicana
Authors: Riggio-Olivares Giovanna 
Published: June 2020

Este artículo ofrece una revisión general del estado actual de la ciencia y la tecnología en la República Dominicana, describiendo la evolución del marco institucional y normativo de este sistema en el nivel nacional, así como las principales políticas públicas, estrategias e instrumentos que se han implementado para la regulación y la promoción de la actividad científica y tecnológica del país. El estudio aporta datos recientes sobre la capacidad, los resultados científicos y el posicionamiento alcanzado por el país en este sector a la luz de algunos indicadores y analiza brevemente el papel que desempeñan las universidades dominicanas en este sistema. Los resultados del análisis realizado indican que, si bien el balance de los indicadores de República Dominicana en la última década es positivo, todavía el país se encuentra lejos de alcanzar el nivel de desarrollo de muchos de los países de América Latina en materia de ciencia y tecnología. Las conclusiones ponen de relieve que la búsqueda de un mejor desempeño del país en este ámbito conlleva la superación de una serie de barreras, señalando debilidades del marco institucional, desarticulación entre los distintos actores del ecosistema nacional de ciencia, tecnología e innovación, escasa capacidad de financiamiento e insuficiente asignación de recursos para la ejecución de proyectos de investigación e innovación y la ausencia de políticas científicas en la mayoría de las universidades dominicanas.
La vorágine: el antiviaje determinista de Arturo Cova
Authors: Paniagua Gutiérrez Edwin Rafael 
Published: June 2020

El presente artículo corresponde a un análisis de la novela La vorágine, de José Eustasio Rivera. En primer lugar, se presenta un contexto de la obra (literario e histórico). Luego, se explica que lo narrado por Arturo Cova no es un viaje, sino un antiviaje: un desplazamiento continuo y forzoso. Se aplica un esquema narratológico mínimo para analizar la trayectoria del personaje principal y, posteriormente, se conceptualiza el determinismo evidenciado en el libro, en sus manifestaciones ambiental, sociológica y psicológica, y se identifica su presencia en la novela. Como metodología, se refieren citas y hechos que justifican la tesis de que Arturo Cova es arrastrado por las circunstancias; por lo cual se trata de un desplazamiento determinista. Él, en lugar de actuar, reacciona. Se deja llevar por las circunstancias. El remolino lo arrastra hacia el fondo. Al final de la obra, se puede constatar que tanto la selva como el azar y los otros lo redefinieron, lo reformaron (¿deformaron?), lo reconstruyeron. Ya no hay ideales, ya no hay presente ni futuro: “la selva lo devoró”.
Período de transición del niño y el adolescente a la adultez tratado con Hormona de Crecimiento Recombinante (RHGH). Una realidad
Authors: Carvajal Martínez Francisco , Piz Ramos Yuraimi , Carvajal Aballe Mónica 
Published: June 2020

La baja talla por Deficiencia de Hormona de Crecimiento es una de las causas endocrinas más frecuentes. El tratamiento se realiza con hormona de crecimiento recombinante (rhgh) durante un período habitualmente de larga duración. Existe un grupo de pacientes que su tratamiento con hormona de crecimiento no concluye en la adultez y debe ser tratado también en ese periodo de la vida. El tema de las transferencias se planteó por primera vez en Estados Unidos en 1984, como consecuencia del importante aumento de supervivencia durante los años setenta y ochenta de niños con patología crónica y discapacitante. Se entiende por transición a una etapa de cambios físicos y psicológicos que, de forma arbitraria, se extiende desde el final de la pubertad hasta que la maduración adulta se completa. Es preciso reevaluar los pacientes con deficiencia de hormona de crecimiento tras alcanzar la talla adulta y definir el estado de la secreción de GH para valorar la conti el periodo de transición y en la adultez.
Percepciones sobre actitudes y deseo sexual en personas que cohabitan en pareja con más de dos años de relación
Authors: Gutiérrez Valerio Rosaura , Chávez Esponda Dunia , Guzmán Esquea Deseado 
Published: June 2020

La sexualidad humana constituye una parte sumamente importante en la vida de las personas, sin embargo, para muchas de ellas se convierte en un tema lleno de mitos y tabúes. Este trabajo tuvo como objetivo explorar la percepción que tenían las parejas con más de dos años de convivencia sobre el deseo y actitudes sexuales como punto de partida para visibilizar las creencias, las conductas aceptadas y rechazadas que pueden estar influenciando en el disfrute o en la disfuncionalidad de una acoplada relación conyugal. Se aplicaron cuestionarios a una muestra de 52 personas del Cantón Puyo, Ecuador. Se incluyeron variables como: edad, sexo, tiempo de relación con la pareja, edad que tenía cuando tuvo su primera relación, si era mujer: situación en su ciclo reproductivo (menstruación, amenorrea, menopaúsica, embarazo) y nivel de estudios. Se utilizaron gráficos de barras, tablas de contingencia y pruebas Chi cuadrado. Los resultados mostraron que, en el campo del deseo, las actitudes sexuales y la fantasía, los hombres manifestaron que les gusta el sexo con mayor frecuencia que las mujeres y que sienten mucho placer o disfrute al pensar en el sexo. En cambio, las mujeres declararon que raramente o algunas veces tienen pensamientos sexuales, observándose una menor motivación por la actividad sexual, ya sea por problemas laborales o financieros, en muchos de los casos encuestados. Estos resultados permitirán reforzar en los talleres realizados, los temas que generaron distanciamientos en las parejas.
Complicaciones del uso de catéter venoso central en pacientes de la Unidad de Cuidados Intensivos en el Hospital General Plaza de la Salud en el período de junio 2017 – junio 2018
Authors: Espiritusanto Lora Darlene , Cabrera Luis Jasmín , Eunice Cid Emilia 
Published: June 2020

Introducción: el uso de un catéter venoso central es esencial para el manejo de miles de paciente en los centros hospitalarios en República Dominicana y el resto del mundo. No obstante, los CVC están asociados a varias complicaciones, incluyendo algunas que son potencialmente fatales.
Método: se realizó un estudio observacional descriptivo retrospectivo en el área de UCI en el Hospital General de la Plaza de la Salud, en el cual se evaluaron los historiales clínicos de 93 pacientes a los que se les colocó un CVC en el periodo de junio 2017 - junio 2018.
Conclusión: en este estudio se observó que dentro de una muestra de 93 pacientes a los cuales se les colocó un CVC en el Hospital General de la Plaza de la Salud en el periodo junio 2017- junio 2018, un 19 % presentaron complicaciones por CVC, siendo la infección la complicación más frecuente.