bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinicopathological Profile of Head and Neck Squamous Cell Carcinoma
Authors: Dasgupta Senjuti , Chakrabarti Sudipta , Deb Asit Ranjan 
Published: December 2019

Abstract
Background: Head and neck squamous cell carcinoma (HNSCC) constitutes one of the most common malignancies in the world. The geographic location influences the etiologic factors and site of tumor. Aims and Objectives: The present study was carried out to illustrate the clinicopathologic profiles of HNSCC patients since data regarding these tumors from eastern region of India are scarce. Materials and Methods: A prospective study was undertaken for 2 years in which patients with histologically proven HNSCC were included. The clinicopathologic features of each case were analyzed. Results: A total of 108 cases were included in the study, among which 79 (73.15%) were male and 29 (26.85%) were female. Mean age of the patients was 53.21 (±12.17) years. The most common risk factor was smoking (63 cases, 58.33%) followed by tobacco or betel nut chewing (41 cases, 37.96%). The common patterns of presentation included ulcerated lesion (51 cases, 47.22%), whitish lesion (28 cases, 25.93%), and hoarseness of voice (11 cases, 10.19%). The most common sites involved were buccal mucosa (36 cases, 33.33%) and dorsal surface of the tongue (26 cases, 24.07%). The most common site for exophytic tumors was buccal mucosa (9 out of 23, 39.13%) and that for ulceroproliferative lesions was tongue (9 out of 17, 52.04%). Microscopically, well-differentiated (Grade I) tumors were most common (67 cases, 62.04%) followed by moderately differentiated (Grade II) tumors (38 cases, 35.19%). A statistically significant correlation was obtained between anatomic site and grade of the tumor. Conclusion: Patients of HNSCC from the eastern region of India have distinctive features with regard to macroscopic appearance and microscopic grade of their tumors.
Cutaneous Malignant Melanoma and Targeted Therapy Based on the Biomarkers
Authors: Pandiaraja Jayabal 
Published: December 2019

AbstractMalignant melanoma is the most aggressive form of cutaneous malignancy. It accounts for more than 75% of cancer-related deaths among cutaneous malignancies. It accounts for <5% of cutaneous malignancy. Numerous biomarkers are used in malignant melanoma with varying clinical applications, including diagnostic purposes, prognosis, therapeutic purpose, and targeted therapy against melanoma. Systemic chemotherapy in malignant melanoma has little benefit compared to immunotherapy and targeted therapy. The observed overall survival with systemic chemotherapy is much less compared with targeted therapy in advanced or metastatic melanoma. Various targeted therapies are currently used in melanoma treatment including BRAF inhibitors such as vemurafenib and dabrafenib; MEK inhibitors such as trametinib; anti-CTLA-4 antibodies such as ipilimumab; and anti-programmed cell death 1 antibodies such as nivolumab, pembrolizumab, and pidilizumab. This study discusses the role of biomarkers and targeted therapies based on the biomarker.
Pediatric Primary Pleural Synovial Sarcoma: A Unique Case Report with Brief Review of Literature
Authors: Vatsayan Anant , Gupta Ajay , Saab Sharazad , Petrosiute Agne 
Published: December 2019

AbstractSynovial sarcoma (SS) primary to the pleura is an extremely rare tumor. So far, only nine cases have been reported in pediatric patients. However, none of these patients was found to have a conglomeration of tumors. Here, we report a case of 16-year-old female with monophasic SS and synchronous occurrence of left paraspinal ganglioneuroma and a right paraovarian cystadenoma. A next-generation sequencing genetic panel revealed a novel variant of unknown significance in the MET gene. The occurrence of multiple different tumors in a young patient with a novel genetic variant in a known oncogene (MET) may suggest a possibility of a hitherto unknown cancer predisposition syndrome. We also present a brief review of primary pleural SS reported in pediatric patients.
Metaplastic Carcinoma of Breast: Case Series with Cytohistological Correlation
Authors: Sood Neelam , Gupta Sanjay , Navmeet Soin 
Published: December 2019

AbstractMetaplastic carcinoma of breast (MCB) is a rare breast malignancy. It is important to differentiate metaplastic carcinoma from malignant phyllodes and primary breast sarcomas because of their differing biological behavior and prognosis. We report four cases of MCB diagnosed over the past 15 years. Retrospective review of patient records in a tertiary care setting to retrieve cases diagnosed as MCB. Patient records of the past 15 years (2002–2015) were retrieved. Four histopathologically diagnosed cases of metaplastic carcinoma out of a total of 880 archived cases of breast carcinoma were studied along with their cytopathology. Immunohistochemistry was performed on sections. MCB comprised 0.45% of all breast malignancies. The four cases of MCB included MCB with chondroid metaplasia, spindle cell carcinoma, adenosquamous carcinoma, and carcinosarcoma. All the tumors were invariably triple negative (estrogen receptor, progesterone receptor, and Her2/Neu negative) and expression of other epithelial and mesenchymal markers was variable. MCB is a rare breast malignancy. Differential diagnosis is related to the presence of heterologous elements and degree of atypia seen in the lesion. It is important to be aware of this entity as it carries a poor prognosis.
MUC2 and MUC5AC Expression in Colon Cancer: A Preliminary Report from South India
Authors: Jayanth R , Devaraj H , Surendran R , Jain Mayank , Venkataraman Jayanthi 
Published: December 2019

Abstract
Background: There is scanty data from India regarding MUC protein expression from colorectal cancers (CRC) among Indian patients. Aim of the Study: The aim of this study is to assess the alterations in the expression of MUC2 and MUC5AC in 25 patients with CRC by site of the tumor location and differentiation at histology. Materials and Methods: Patients with proven adenocarcinoma of the colon alone were included for the study. Biopsy specimens obtained from tumorous lesions in the colon were classified based on histopathology as well differentiated, moderately, and poorly differentiated adenocarcinoma. Immunohistochemistry was done in the 4 μm thick sections to identify the expression of MUC2 and MUC5AC mucins. Results: MUC2 was uniformly expressed with near similar intensity while MUC5 was moderately (56%) to highly expressed (36%) in mucinous tumors. In nonmucinous tumors, MUC2 was least expressed (68%) with a significant expression on MUC5AC (88%). Except for rectosigmoid growth which had greater expression of MUC5AC (31%), both proximal and distal carcinomas had significant MUC2 and MUC5AC expression. Conclusion: MUC2 and MUC5AC are expressed in colonic cancers, the former showing mildtomoderate expression and the latter moderatetointense expression. The expression is more in mucinous adenocarcinoma.
Is High Altitude an Emergent Occupational Hazard for Primary Malignant Brain Tumors in Young Adults? A Hypothesis
Authors: Sharma Neelam , Purkayastha Abhishek , Pandya Tejas 
Published: December 2019

Abstract
Introduction: Brain cancer accounts for approximately 1.4% of all cancers and 2.3% of all cancer-related deaths. Although relatively rare, the associated morbidity and mortality affecting young- and middle-aged individuals has a major bearing on the death-adjusted life years compared to other malignancies. Over the years, we have observed an increase in the incidence of primary malignant brain tumors (PMBTs) in young adults. This observational analysis is to study the prevalence and pattern of brain tumors in young population and find out any occupational correlation. Materials and Methods: The data were obtained from our tertiary care cancer institute's malignant diseases treatment center registry from January 2008 to January 2018. A total of 416 cases of PMBT were included in this study. Results: Our analysis suggested an overall male predominance with most PMBTs occurring at ages of 20–49 years. The glial tumors constituted 94.3% while other histology identified were gliosarcoma (1) gliomatosis cerebri (1), hemangiopericytoma (3), and pineal tumors (3). In our institute, PMBT constituted 1% of all cancers while 2/416 patients had secondary glioblastoma multiforme with 40% showing positivity for O-6-methylguanine-DNA-methyltransferase promoter methylation. Conclusions: Most patients belonged to a very young age group without any significant family history. A probable hypothesis could be excessive cosmic radiation exposure to persons staying at high altitude areas due to occupational exigencies for which in-depth case–control epidemiological studies are required to reach any conclusion.
Coupled Systems of Renewal Equations for Forces of Infection through a Contact Network
Authors: Alavinejad Mahnaz , Wu Jianhong 
Published: December 2019

AbstractWe formulate a coupled system of renewal equations for the forces of infections in interacting subgroups through a contact network. We use the theory of order-preserving and sub-homogeneous discrete dynamical systems to show the existence and uniqueness of the disease outbreak final sizes in the sub-populations. We illustrate the general theory through a simple SIR model with exponentially and non-exponentially distributed infectious period.
The Range of the Cesàro Operator Acting on
Authors: Bao Guanlong , Wulan Hasi , Ye Fangqin 
Published: December 2019

AbstractIn 1993, N. Danikas and A. G. Siskakis showed that the Cesàro operator ${\mathcal{C}}$ is not bounded on $H^{\infty }$; that is, ${\mathcal{C}}(H^{\infty })\nsubseteq H^{\infty }$, but ${\mathcal{C}}(H^{\infty })$ is a subset of $BMOA$. In 1997, M. Essén and J. Xiao gave that ${\mathcal{C}}(H^{\infty })\subsetneq {\mathcal{Q}}_{p}$ for every $0<p<1$. In this paper, we characterize positive Borel measures $\unicode[STIX]{x1D707}$ such that ${\mathcal{C}}(H^{\infty })\subseteq M({\mathcal{D}}_{\unicode[STIX]{x1D707}})$ and show that ${\mathcal{C}}(H^{\infty })\subsetneq M({\mathcal{D}}_{\unicode[STIX]{x1D707}_{0}})\subsetneq \bigcap _{0<p<\infty }{\mathcal{Q}}_{p}$ by constructing some measures $\unicode[STIX]{x1D707}_{0}$. Here, $M({\mathcal{D}}_{\unicode[STIX]{x1D707}})$ denotes the Möbius invariant function space generated by ${\mathcal{D}}_{\unicode[STIX]{x1D707}}$, where ${\mathcal{D}}_{\unicode[STIX]{x1D707}}$ is a Dirichlet space with superharmonic weight induced by a positive Borel measure $\unicode[STIX]{x1D707}$ on the open unit disk. Our conclusions improve results mentioned above.
Presenting the Research Track Abstracts From the 2019 AOTA Annual Conference & Expo
Authors: Harvison Neil 
Published: December 2019

Abstract
Each year, the American Occupational Therapy Association publishes an online supplement to the American Journal of Occupational Therapy consisting of the peer-reviewed “research track” abstracts of presentations at the AOTA Annual Conference & Expo. The abstracts are in five categories: (1) assessment and measurement, (2) basic research, (3) health services research and education, (4) prevention and intervention, and (5) translational research. The current supplement consists of the abstracts presented April 4 to April 7, 2019, in New Orleans, Louisiana.
Artificiële intelligentie en normatieve ethiek
Authors: Lauwaert Lode 
Published: December 2019

Abstract

Artificial intelligence and normative ethics: Who is responsible for the crime of LAWS?

In his text “Killer Robots”, Robert Sparrow holds that killer robots should be forbidden. This conclusion is based on two premises. The first is that attributive responsibility is a necessary condition for admitting an action; the second premise is that the use of killer robots is accompanied by a responsibility gap. Although there are good reasons to conclude that killer robots should be banned, the article shows that Sparrow's argument for the ban is not correct.
Nietzsches Einverleibung als leertheorie
Authors: Gellens Sven 
Published: December 2019

AbstractNietzsche’sEinverleibungas learning theory: Towards an integrated corporality in pedagogy and philosophy educationThe traditional distinction of Western philosophy between body and mind still permeates many contemporary pedagogical frameworks. In this article, I will reconstruct in Nietzsche’s philosophy the basis for a constructive pedagogical model that understands learners in an integrated way. The first part of this article will argue that this model ofembodiment(‘Einverleibung’) forms a learning theoretical foundation. In the second part, I will build on this Nietzschean learning theory in order to re-evaluate specific contemporary pedagogical trends, a.o. Bloom’s taxonomy and competency-based education within the context of expertise development. Finally, I elaborate on the meaning of Nietzsche’s model of Einverleibung for a 21st century philosophy education thatembodiesan emancipatory and inclusive didactic.
A CONSTITUTIVE MODEL FOR BOTH LOW AND HIGH STRAIN NONLINEARITIES IN HIGHLY FILLED ELASTOMERS AND IMPLEMENTATION WITH USER-DEFINED MATERIAL SUBROUTINES IN ABAQUS
Authors: Hohenberger Travis W. , Windslow Richard J. , Pugno Nicola M. , Busfield James J. C. 
Published: December 2019

ABSTRACT
Strain energy functions (SEFs) are used to model the hyperelastic behavior of rubberlike materials. In tension, the stress–strain response of these materials often exhibits three characteristics: (i) a decreasing modulus at low strains (&lt;20%), (ii) a constant modulus at intermediate strains, and (iii) an increasing modulus at high strains (&gt;200%). Fitting an SEF that works in each regime is challenging when multiple or nonhomogeneous deformation modes are considered. The difficulty increases with highly filled elastomers because the small strain nonlinearity increases and finite-extensibility occurs at lower strains. One can compromise by fitting an SEF to a limited range of strain, but this is not always appropriate. For example, rubber seals in oilfield packers can exhibit low global strains but high localized strains. The Davies–De–Thomas (DDT) SEF is a good candidate for modeling such materials. Additional improvements will be shown by combining concepts from the DDT and Yeoh SEFs to construct a more versatile SEF. The SEF is implemented with user-defined material subroutines in Abaqus/Standard (UHYPER) and Abaqus/Explicit (VUMAT) for a three-dimensional general strain problem, and an approach to overcome a mathematically indeterminate stress condition in the unstrained state is derived. The complete UHYPER and VUMAT subroutines are also presented.
What should guide priority setting in health care? A study of public preferences in Sweden
Authors: Ryen Linda , Jakobsson Niklas , Svensson Mikael 
Published: December 2019

Priority setting criteria in health care are commonly set by politicians on behalf of the public. It is desirable that these criteria are in line with societal preferences in order to gain acceptance for decisions on what health services to provide and reimburse. We study public preferences for the allocation of the health care budget based on age, disease severity and treatment cost. We use data from a web survey where 1,160 respondents provided their views on priority setting criteria in health care. The data was analyzed using multinomial logistic regression analyses and one-sample proportion tests. Between 13 to 25 percent of the respondents agree that age, disease severity and treatment cost are valid criteria for priority setting, whereas 56 to 80 percent support weaker versions of the statements. We also find significant differences within the population; young men are for example more prone to support explicit priority setting criteria. Our results imply a need for trade-offs in health care priority setting if balancing differing preferences among population groups. To achieve a greater understanding for priority setting in general, and for using economic reasoning in particular, there may be a need for more public transparency to make clear that priority setting is inevitable.
Published: Online December 2019
MODELOS ESTADÍSTICOS PARA EL ANÁLISIS FUNCIONAL DE LOS PROCESOS DE GRAMATICALIZACIÓN EN LAS CONSTRUCCIONES PROGRESIVAS DEL INGLÉS
Authors: Van Arkel Simón Carlos 
Published: December 2019

En este artículo se analizan las relaciones cuantitativas existentes entre las construcciones progresivas del inglés y diferentes patrones funcionales, cuantificables a partir del conjunto de corpora York-Toronto-Helsinki-Penn, en aras de ilustrar los procesos de gramaticalización que experimentan estas construcciones. Se elabora un análisis estadístico que prueba la existencia de relaciones significativas entre los aumentos en las frecuencias de aparición normalizadas de las construcciones progresivas y la evolución de cuatro dimensiones funcionales del modelo multifactorial, así como entre los aumentos en el indicador estimado de los procesos de gramaticalización y tres de dichas dimensiones, en ambos casos, en función del género textual. Asimismo, se describen las principales tendencias de las formas progresivas totales y cinco de sus variantes sintácticas en función de las dimensiones relevantes del modelo multifactorial, así como el período de la lengua.ABSTRACTIn this paper we examine the quantitative relations between English progressive constructions and different functional patterns, measurable on the family of corpora York-Toronto-Helsinki-Penn, in order to illustrate the grammaticalization processes undergone by these constructions. We conduct a statistical analysis that demonstrates significant relationships between the increments in the standardized frequencies of progressive constructions and the changing patterns of four functional dimensions from the multidimensional model, and between the increase in the estimated index of grammaticalization and three of these dimensions, in both cases, according to textual genre. We also describe the main tendencies of the total number of progressive forms and five of its syntactic variants related to the relevant dimensions of the multidimensional model and the historical period.
Fraudes, violences et autres comportements déviants dans le sport professionnel et olympique
Authors: Caneppele12 Stefano , Cinaglia Giulia , Sperrer Christina , Langlois Fiona 
Published: December 2019

Les sources ouvertes en ligne sont de plus en plus utilisées comme outils de renseignement. Cette contribution explore la manière dont elles peuvent être utilisées pour étudier la déviance dans le sport professionnel et olympique. L’étude a considéré les fraudes perpétrées sur le terrain (le dopage, la manipulation de match et les fraudes à l’éligibilité) et en dehors (la corruption), les violences sur et en dehors du terrain de jeu (le hooliganisme et le terrorisme), ainsi que les autres comportements préjudiciables commis par les sportifs, que ce soit sur le terrain ou en dehors. Un dispositif de veille en ligne a été mis en place pour la récolte d’articles publiés en 2016 en anglais. Des 775 cas qui ont été relevés, les fraudes (surtout les cas de dopage et de manipulations de matchs) comptaient à elles seules pour 85 % des cas. Au total, 87 pays sont impliqués dans cette étude, bien que certaines sous-régions – l’Europe de l’Est (17,4 %), l’Afrique de l’Est (16,1 %), ainsi que l’Australie et la Nouvelle-Zélande (10,2 %) – se démarquent par une concentration plus élevée de cas. Quant aux patterns temporels, des distributions sont concentrées surtout aux mois d’août et novembre pour les fraudes, et aux mois de juin et juillet pour les violences. Ces tendances peuvent laisser supposer une saisonnalité des comportements déviants. En se concentrant sur les biais liés au langage et aux types de sources, des recherches plus approfondies sur le sujet pourraient contribuer à une surveillance systématique de la représentation médiatique de ces phénomènes dans le monde.
STUDI FENOMENOLOGI: MEKANISME KOPING PEREMPUAN YANG BELUM MEMPUNYAI KETURUNAN DITINJAU DARI ASPEK BUDAYA MINANGKABAU
Authors: Rahmaniza Rahmaniza , Riasmini Ni Made , Netrida Netrida 
Published: December 2019

Phenomenology Study: Coping Mechanism of Women No Heredity Viewed by Minangkabau Culture. The Minangkabau tribe adheres to the matrilineal kinship system. Based on this system, when a woman suffers infertility, so it means the family has not the next generation, and the line of descent will cut off. This condition makes the women need to have a coping mechanism to avoid psychology problems, including depression, anxiety, stress, neglected, discrimination, under pressure to divorce, and perceive abused. The study aimed to explore the coping mechanism of infertility women in the context of Minangkabau culture. This phenomenology study applied an in-depth interview, which involved ten women who were selected through a snowball sampling technique. Collaizi’s analysis method resulted in six themes. Those themes are through psychological and social change, obtain a response from others, the views of Minangkabau culture, adaptive coping used by women no heredity, the families were main source support, community social support. The findings strengthen the justification to involve psycho-social aspects in the infertility treatment.Keywords: Coping mechanism, infertile women, Minangkabau culture Abstrak Suku Minangkabau menganut sistem kekerabatan matrilineal. Berdasarkan sistem ini, ketika seorang wanita menderita kemandulan, itu berarti keluarga tidak memiliki generasi berikutnya, dan garis keturunan akan terputus. Kondisi ini membuat perempuan perlu memiliki mekanisme koping untuk menghindari masalah psikologi, termasuk depresi, kecemasan, stres, diabaikan, diskriminasi, di bawah tekanan untuk bercerai, dan juga merasa dilecehkan. Penelitian ini bertujuan untuk mengeksplorasi mekanisme koping wanita infertilitas dalam konteks budaya Minangkabau. Studi fenomenologi ini menerapkan wawancara mendalam yang melibatkan sepuluh wanita yang dipilih melalui teknik pengambilan sampel bola salju. Melalui metode analisis dari Collaizi, menghasilkan enam tema. Tema-tema tersebut termasuk Mengalami perubahan psikologis dan perubahan sosial, mendapat respon dari orang sekitarnya, pandangan budaya Minangkabau, koping adaptif yang digunakan oleh perempuan belum mempunyai keturunan, keluarga menjadi sumber dukungan utama, dukungan sosial dari masyarakat. Temuan ini memperkuat pembenaran untuk melibatkan aspek psiko-sosial dalam pengobatan infertilitas. Kata kunci: Budaya Mingkabau, mekanisme koping, perempuan infertile
Interdiffusion during heteroepitaxial Au growth on Pd thin films by electroless Au plating (ELGP) at room temperature
Authors: Yang Mingyue , Toyama Ryo , Tue Phan Trong , Majima Yutaka 
Published: December 2019

Abstract
Electroless Au plating (ELGP) on Pd thin films is performed. The ELGP time dependence on the surface morphology is investigated by a scanning electron microscope. Continuous nucleation and growth of hemispherical Au islands are observed as the plating time increases. Heteroepitaxial growth of the electroless plated Au on the Pd surface is confirmed by cross-sectional scanning transmission electron microscope images. Cross-sectional energy-dispersive X-ray spectroscopy reveals interdiffusion between the Pd atoms and the plated Au atoms at room temperature, which allows the formation of Au–Pd alloys. The heteroepitaxial Au growth on Pd is significant for reducing contact resistance of Au/Pd structures.