bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robust design from systems physics
Authors: Klishin Andrei A. , Kirkley Alec , Singer David J. , van Anders Greg 
Published: August 2020

AbstractA crucial challenge in engineering modern, integrated systems is to produce robust designs. However, quantifying the robustness of a design is less straightforward than quantifying the robustness of products. For products, in particular engineering materials, intuitive, plain language terms of strong versus weak and brittle versus ductile take on precise, quantitative meaning in terms of stress–strain relationships. Here, we show that a “systems physics” framing of integrated system design produces stress–strain relationships in design space. From these stress–strain relationships, we find that both the mathematical and intuitive notions of strong versus weak and brittle versus directly characterize the robustness of designs. We use this to show that the relative robustness of designs against changes in problem objectives has a simple graphical representation. This graphical representation, and its underlying stress–strain foundation, provide new metrics that can be applied to classes of designs to assess robustness from feature- to system-level.
Synchrotron radiation Ca K-edge 2D-XANES spectroscopy for studying the stratigraphic distribution of calcium-based consolidants applied in limestones
Authors: Monico Letizia , Cartechini Laura , Rosi Francesca , De Nolf Wout , Cotte Marine , Vivani Riccardo , Maurich Celeste , Miliani Costanza 
Published: August 2020

AbstractIn Heritage Science, the evaluation of stone consolidation treatments by investigating the nature of in situ newly formed products and their penetration depth within the consolidated matrix is a grand challenge. A number of analytical methods have been proposed, but, currently, most of them are not able to supply a full overview of the spatial, structural and compositional information of the newly formed crystalline and amorphous phases with a submicrometric lateral resolution. Here, we examined, the capabilities of synchrotron radiation (SR)-based two-dimensional X-ray absorption near-edge structure (2D-XANES) spectroscopy at Ca K-edge for determining the structural and compositional properties of the compounds formed after the application of a calcium acetoacetate-based consolidant on a porous carbonatic stone (limestone) and for investigating their stratigraphic distribution at the submicrometric scale length. We evaluated advantages and drawbacks of three Ca K-edge 2D-XANES-based approaches: (i) transmission mode full-field-XANES (FF-XANES) imaging; (ii) micro-X-ray fluorescence (μ-XRF) mapping above the Ca K-edge combined with the acquisition of XRF mode μ-XANES spectra at a limited number of spots; (iii) full-spectral µ-XANES (FS µ-XANES) mapping in XRF mode and its variant called selectively induced X-ray emission spectroscopy (SIXES) mapping. Overall, Ca K-edge 2D-XANES spectroscopy provided accurate qualitative and semi-quantitative information on the newly formed calcium carbonates (i.e., amorphous calcium carbonate, vaterite and calcite) and their stratigraphic distribution at the submicrometric scale, thus opening a new scenario to study the carbonatation process of calcium-based consolidants in limestones.
Insights into the molecular-level effects of atmospheric and room-temperature plasma on mononucleotides and single-stranded homo- and hetero-oligonucleotides
Authors: Wang Liyan , Zhao Hongxin , He Dong , Wu Yinan , Jin Lihua , Li Guo , Su Nan , Li Heping , Xing Xin-Hui 
Published: August 2020

AbstractAtmospheric and room-temperature plasma (ARTP) has been successfully developed as a useful mutation tool for mutation breeding of various microbes and plants as well animals by genetic alterations. However, understanding of the molecular mechanisms underlying the biological responses to ARTP irradiation is still limited. Therefore, to gain a molecular understanding of how irradiation with ARTP damages DNA, we irradiated the artificially synthesized mononucleotides of dATP, dTTP, dGTP, and dCTP, and the oligonucleotides of dA8, dT8, dG8, dC8, and dA2dT2dG2dC2 as chemical building blocks of DNA with ARTP for 1–4 min, identified the mononucleotide products using 31P- and 1H-nuclear magnetic resonance spectroscopy (NMR), and identified the oligonucleotide products using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) during ARTP treatment. The observed 31P-and 1H-NMR spectrum signals for the plasma-treated and untreated mononucleotides indicated that dATP was less stable to plasma irradiation than the other mononucleotides. The oligonucleotides after treatment with ARTP were found to have been broken into small fragments as shown by mass spectrometry, with the cleaved bonds and produced fragments identified according to their expected spectral m/z values or molecular weights derived from their m/z values. The stabilities of the oligonucleotides differed to ARTP irradiation, with dT8 being the most stable and was more beneficial to stabilizing single-stranded oligonucleotide structures compared to the other base groups (A, G, and C). This was consistent with the average potential energy level obtained by the molecular dynamic simulation of the oligonucleotides, i.e., dT8 > dC8 > dA8 > dG8 > dA2dT2dG2dC2. In summary, we found that ARTP treatment caused various structural changes to the oligonucleotides that may account for the wide and successful applications reported for ARTP-induced mutation breeding of various organisms.
Floquet engineering of topological metal states and hybridization of edge states with bulk states in dimerized two-leg ladders
Authors: Jangjan Milad , Hosseini Mir Vahid 
Published: August 2020

AbstractWe consider asymmetric and symmetric dimerized two-leg ladders, comprising of four different lattice points per unit cell, illuminated by circularly polarized light. In the asymmetric dimerized ladder case, rungs are not perpendicular to the ladder’s legs whereas the rungs are perpendicular to the legs for the symmetric one. Using the Floquet theory, we obtain an effective Hamiltonian to study topological properties of the systems. Depending on the dimerization strength and driving amplitude, it is shown that topologically protected edge states manifest themselves not only as a zero-energy band within the gap between conduction and valence band but also as finite-energy curved bands inside the gap of subbands. The latter one can penetrate into bulk states and hybridize with the bulk states revealing hybridized Floquet topological metal phase with delocalized edge states in the asymmetric ladder case. However, in the symmetric ladder, the finite-energy edge states while remaining localized can coexist with the extended bulk states manifesting Floquet topological metal phase.
Growth retardation-responsive analysis of mRNAs and long noncoding RNAs in the liver tissue of Leiqiong cattle
Authors: Kong Lingxuan , Liu Guangbin , Deng Ming , Lian Zhiquan , Han Yinru , Sun Baoli , Guo Yongqing , Liu Dewu , Li Yaokun 
Published: August 2020

AbstractAs an important type of non-coding RNA molecule, long non-coding RNAs (lncRNAs) have varied roles in many biological processes, and have been studied extensively over the past few years. However, little is known about lncRNA-mediated regulation during cattle growth and development. Therefore, in the present study, RNA sequencing was used to determine the expression level of mRNAs and lncRNAs in the liver of adult Leiqiong cattle under the condition of growth retardation and normal growth. We totally detected 1,124 and 24 differentially expressed mRNAs and lncRNAs, respectively. The differentially expressed mRNAs were mainly associated with growth factor binding, protein K63-linked ubiquitination and cellular protein metabolic process; additionally, they were significantly enriched in the growth and development related pathways, including PPAR signaling pathway, vitamin B6 metabolism, glyoxylate and dicarboxylate metabolism. Combined analysis showed that the co-located differentially expressed lncRNA Lnc_002583 might positively influence the expression of the corresponding genes IFI44 and IFI44L, exerting co-regulative effects on Leiqiong cattle growth and development. Thus, we made the hypothesis that Lnc_002583, IFI44 and IFI44L might function synergistically to regulate the growth of Leiqiong cattle. This study provides a catalog of Leiqiong cattle liver mRNAs and lncRNAs, and will contribute to a better understanding of the molecular mechanism underlying growth regulataion.
Sex-specific effects of the histone variant H2A.Z on fear memory, stress-enhanced fear learning and hypersensitivity to pain
Authors: Ramzan Firyal , Creighton Samantha D. , Hall Meaghan , Baumbach Jennet , Wahdan Malak , Poulson Sandra J. , Michailidis Vassilia , Stefanelli Gilda , Narkaj Klotilda , Tao Cindy S. , Khan Dure , Steininger Carl F. D. , Walters Brandon J. , Monks D. Ashley , Martin Loren J. , Zovkic Iva B. 
Published: August 2020

AbstractEmerging evidence suggests that histone variants are novel epigenetic regulators of memory, whereby histone H2A.Z suppresses fear memory. However, it is not clear if altered fear memory can also modify risk for PTSD, and whether these effects differ in males and females. Using conditional-inducible H2A.Z knockout (cKO) mice, we showed that H2A.Z binding is higher in females and that H2A.Z cKO enhanced fear memory only in males. However, H2A.Z cKO improved memory on the non-aversive object-in-place task in both sexes, suggesting that H2A.Z suppresses non-stressful memory irrespective of sex. Given that risk for fear-related disorders, such as PTSD, is biased toward females, we examined whether H2A.Z cKO also has sex-specific effects on fear sensitization in the stress-enhanced fear learning (SEFL) model of PTSD, as well as associated changes in pain sensitivity. We found that H2A.Z cKO reduced stress-induced sensitization of fear learning and pain responses preferentially in female mice, indicating that the effects of H2A.Z depend on sex and the type of task, and are influenced by history of stress. These data suggest that H2A.Z may be a sex-specific epigenetic risk factor for PTSD susceptibility, with implications for developing sex-specific therapeutic interventions.
Optimization of subsampling, decontamination, and DNA extraction of difficult peat and silt permafrost samples
Authors: Saidi-Mehrabad Alireza , Neuberger Patrick , Cavaco Maria , Froese Duane , Lanoil Brian 
Published: August 2020

AbstractThis study aims to act as a methodological guide for contamination monitoring, decontamination, and DNA extraction for peaty and silty permafrost samples with low biomass or difficult to extract DNA. We applied a biological tracer, either only in the field or both in the field and in the lab, via either spraying or painting. Spraying in the field followed by painting in the lab resulted in a uniform layer of the tracer on the core sections. A combination of bleaching, washing, and scraping resulted in complete removal of the tracer leaving sufficient material for DNA extraction, while other widely used decontamination methods did not remove all detectable tracer. In addition, of four widely used commercially available DNA extraction kits, only a modified ZymoBIOMICS DNA Microprep kit was able to acquire PCR amplifiable DNA. Permafrost chemical parameters, age, and soil texture did not have an effect on decontamination efficacy; however, the permafrost type did influence DNA extraction. Based on these findings, we developed recommendations for permafrost researchers to acquire contaminant-free DNA from permafrost with low biomass.
The satellite observed glacier mass changes over the Upper Indus Basin during 2000–2012
Authors: Abdullah Tariq , Romshoo Shakil Ahmad , Rashid Irfan 
Published: August 2020

AbstractDecadal glacier thickness changes over the Upper Indus Basin in the Jammu and Kashmir Himalaya were estimated using the TanDEM-X and SRTM-C Digital Elevation Models (DEMs) from 2000 to 2012. In the study area 12,243 glaciers having 19,727 ± 1,054 km2 area have thinned on an average of − 0.35 ± 0.33 m a−1 during the observation period. The highest thinning of − 1.69 ± 0.60 m a−1 was observed in the Pir Panjal while as the marginal thinning of − 0.11 ± 0.32 m a−1 was observed for the glaciers in the Karakoram. The observed glacier thickness changes indicated a strong influence of the topographic parameters. Higher thickness reduction was observed on the glaciers situated at lower altitudes (− 1.40 ± 0.53 m a−1) and with shallower slopes (− 1.52 ± 0.40 m a−1). Significantly higher negative thickness changes were observed from the glaciers situated on the southern slopes (− 0.55 ± 0.37 m a−1). The thickness loss was higher on the debris-covered glaciers (− 0.50 ± 0.38 m a−1) than on the clean glaciers (− 0.32 ± 0.33 m a−1). The cumulative glacier mass loss of − 70.32 ± 66.69 Gt was observed during the observation period, which, if continued, would significantly affect the sustainability of water resources in the basin.
Drought characteristics and its elevation dependence in the Qinghai–Tibet plateau during the last half-century
Authors: Feng Wei , Lu Hongwei , Yao Tianci , Yu Qing 
Published: August 2020

AbstractAssociated with global warming, drought has destructive influences on agriculture and ecosystems, especially in the fragile Qinghai–Tibet Plateau (QTP). This study investigated spatial–temporal patterns of meteorological drought in the QTP and its surrounding areas and made an attempt to explore the relationship between drought conditions and elevation. Robust monitoring data from 274 meteorological stations during 1970–2017 were analyzed using the Sen’s slope method, Mann–Kendall trend test and rescaled range analysis. Results revealed that under the wetting trend in the QTP, Standardized Precipitation Evapotranspiration Index (SPEI) increased of maximum 0.012/year in spring. Moreover, severe drought frequency in winter and future drought risk in summer also showed an increasing trend. Wetter trends were positively correlated with elevation, with a key point being 4,000 m where the change trend above 4,000 m was about 6.3 times of that below 4,000 m in study area. The difference of drought severities between SPEI in the QTP and its surrounding areas has increased from − 0.19 in 1970 to 0.38 in 2017 and kept growing in future.
Nitrogen availability and genotype affect major nutritional quality parameters of tef grain grown under irrigation
Authors: Tietel Zipora , Simhon Ella , Gashu Kelem , Ananth Devanesan Arul , Schwartz Betty , Saranga Yehoshua , Yermiyahu Uri 
Published: August 2020

AbstractWorldwide demand for tef (Eragrostis tef) as a functional food for human consumption is increasing, thanks to its nutritional benefits and gluten-free properties. As a result, tef in now grown outside its native environment in Ethiopia and thus information is required regarding plant nutrition demands in these areas, as well as resulting grain health-related composition. In the current work, two tef genotypes were grown in Israel under irrigation in two platforms, plots in the field and pots in a greenhouse, with four and five nitrogen treatments, respectively. Nutritional and health-related quality traits were analyzed, including mineral content, fatty acid composition, hydrophilic and lipophilic antioxidative capacity, total phenolic content and basic polyphenolic profile. Our results show that tef genotypes differ in their nutritional composition, e.g. higher phenolic contents in the brown compared to the white genotype. Additionally, nitrogen availability positively affected grain fatty acid composition and iron levels in both experiments, while negatively affecting total phenolics in the field trials. To conclude, nitrogen fertilization is crucial for crop growth and productivity, however it also implicates nutritional value of the grains as food. These effects should be considered when fertilizing tef with nitrogen, to optimize both crop productivity and nutritional effects.
New insights into the food web of an Australian tropical river to inform water resource management
Authors: Beesley Leah S. , Pusey Bradley J. , Douglas Michael M. , Gwinn Daniel C. , Canham Caroline A. , Keogh Chris S. , Pratt Oliver P. , Kennard Mark J. , Setterfield Samantha A. 
Published: August 2020

AbstractRivers around the world are threatened by altered flow due to water resource development. Altered flow can change food webs and impact riverine energetics. The Fitzroy River, in northern Australia, is targeted for development but uncertainty remains about the sources of carbon supporting the food web, particularly in the lowlands—the region most likely to be impacted by water extraction. This study used stable isotopes to investigate if algal biofilm is the main carbon source sustaining fish in lowland habitats. We also sought evidence that large-bodied migratory fish were transporting remote carbon around the system. Our results revealed that local algal biofilm carbon was the dominant source of energy sustaining fish in wet season floodplain habitats, but that fish in main-channel pools during the dry season were increasingly dependent on other carbon sources, such as leaf litter or phytoplankton. We found no evidence that large-bodied fish were transporting remote carbon from the floodplain or estuary into the lower main-channel of the river. We recommend that water planners take a precautionary approach to policy until sufficient food web evidence is amassed.
Dermatoskopie, sequenzielle Videodermatoskopie, Ganzkörperfotografie, künstliche Intelligenz – was bringt uns die Zukunft?
Authors: Deinlein T. , Hofmann-Wellenhof R. , Hänßle H. A. , Blum A. 
Published: August 2020

ZusammenfassungDie Dermatoskopie ist mittlerweile ein fester Bestandteil einer jeden dermatologischen Untersuchung. Mit dieser Technik konnten die Früherkennung von Malignomen der Haut und deren Vorstufen deutlich verbessert und unnötige Exzisionen benigner Hautläsionen reduziert werden. Der Einsatz der Dermatoskopie umfasst mittlerweile auch die Beurteilung von entzündlichen und parasitären Dermatosen sowie Haarerkrankungen. Bei definierten Risikogruppen für ein Melanom sollte der 2-Schritte-Algorithmus, bestehend aus Ganzkörperfotografie und Videodermatoskopie, in entsprechenden Zeitintervallen zur Anwendung kommen. Mit dieser Methode können Melanome meist in einem sehr frühen Stadium entdeckt werden, da Veränderungen bestehender Muttermale sowie neu entstandene Läsionen früher festgestellt werden. In den letzten Jahren konnten mehrere Studien nachweisen, dass speziell geschulte neuronale Netzwerke Malignome der Haut, insbesondere Melanome, mit einer sehr hohen Treffsicherheit diagnostizieren können. Wie diese computergestützte Diagnostik mithilfe einer künstlichen Intelligenz in den klinischen Alltag integriert werden kann und welche Vorteile sich hiervon ableiten lassen, ist derzeit noch nicht geklärt.
Durch malignes Melanom ein zum damaligen Zeitpunkt lebensbedrohliches Phäochromozytom entdeckt – Glück im Unglück: 14 Jahre Rezidivfreiheit
Authors: Vavouli Maria , Shab Catharina 
Published: August 2020

ZusammenfassungDas Phäochromozytom ist ein seltener Tumor, der in den meisten Fällen zu spät entdeckt wird. Oft handelt es sich hierbei um einen Zufallsbefund. Wir berichten über einen Fall eines malignen Melanoms, das durch sein Staging geholfen hat, ein Phäochromozytom rechtzeitig zu entdecken. In diesem Fall führte das maligne Melanom glücklicherweise zur frühzeitigen Phäochromozytom-Diagnose mit 14 Jahren Überleben ohne Rückfall.
Adjunctive Procedures in Facelifting
Authors: Winslow Catherine P. 
Published: August 2020

AbstractRhytidectomy, or facelift in layman's terms, is performed to reverse the appearance of facial aging. A lift can improve volume shifts with age, reposition sagging tissues, and eliminate skin redundancy. There are limitations to what can be accomplished with a facelift alone. Commonly performed adjuncts including surgery to the eyelids or brows, liposuction, and even rhinoplasty can be combined to improve the result. Further options exist that are more commonly overlooked or rarely offered to patients but can greatly enhance the surgeon's ability to remove years from the face. This article will cover some additional options that every facial plastic surgeon should be familiar with and experienced to both describe and perform.
Complications in Lower Face Rejuvenation: Avoiding, Minimizing, Recognizing, Dealing with Them, and Helping the Patient through the Process of Fixing the Problems
Authors: Truswell William H. 
Published: August 2020

AbstractAll surgical and minimally invasive procedures carry a risk of complications. It is imperative that the facial plastic surgeon and his/her staff are well educated in recognizing and managing all the possible problems that could arise. They must also be ready and able to deal with and correct any problem. The patient undergoing surgery or a procedure also needs to be informed of all possible sequelae and complications. Sequelae will happen after almost all procedures. These include soreness, swelling, bruising, and so on. If the patients understand that these are to be expected, they will be less likely to be overly concerned about them. They also must be educated about all the possible complications. They should be told that while complications are very rare, they could nevertheless happen. If a problem should arise, the surgeon and his/her staff should correct it and see that the patient receives the best care possible. This article examines the complications that could occur after rejuvenation surgery and minimally invasive procedures of the lower face and neck, what measures can be undertaken to reduce the risks, and how to recognize and manage them.
The Facelift in South American Patients
Authors: Patrocinio Lucas Gomes , Naves Marcell Melo , Patrocinio Jose Antonio 
Published: August 2020

AbstractSouth America is a vast territory; its people were made from all parts of the world. The miscegenation made a unique population comprised of Indian, Asian, Caucasian, African, Mestizo, Mulatto, and Zambo. The South American patients tend to have a wider face with a skin-soft tissue envelope (S-STE) that is thicker, heavier, and has less elasticity than the Caucasian patient. Upper eyelids may hood easily. In the same way, malar eminences and round face look are more prominent. The chin can be a little retracted. With aging, the S-STE tends to sag more, making nasolabial folds and jowl area more prominent, and redundant neck skin will appear loose and heavy. Facelift is popular in South American patients. They have peculiar characteristics like heavy dark sebaceous skin which lead to peculiarities in face lifting. It is usually a procedure designed to rejuvenate all thirds of the face. In the forehead, skin excision in temporal incisions is usually necessary. Midface subperiosteal lift is a possibility for heavy skin patients who need great improvement in the center of the face. The neck lift is almost indispensable to the rejuvenation of the lower third. Extended superficial muscular aponeurotic system or deep plane dissection is commonly performed so the soft tissues of the midface, the jowls, and the neck can be lifted to reestablish their youthful relationship with the underlying skeleton.