bluuebunny/crossref_metadata_2025_split huggingface dataset:
Follicular lymphoma transforming to DLBCL and reverting back to follicular lymphoma at relapse—a case report
Authors: Suresh Babu M. C. , Thottian Antony George Francis , Lokanatha D. , Jacob Linu Abraham , Lokesh K. N. , Rudresha A. H. , Rajeev L. K. , Smitha Saldanha , Hassan Syed Adil , Ashok Khandare Pravin , Premalatha C. S. , Suma M. N. 
Published: May 2020

Abstract
Background
Transformation of low-grade follicular lymphoma to high-grade diffuse large B cell lymphoma (DLBCL) is known. However, the opposite is not commonly reported. In this report, we present a case of follicular lymphoma that underwent transformation to DLBCL. Three years after treatment for histologic transformation, the patient presented again with low-grade follicular lymphoma at the same site which is unusual in the natural history of follicular lymphoma.

Case presentation
A 50-year-old female patient presented to us with complaints of slowly progressing swelling in the neck on the left side for a duration of 1 year. Past history of the patient revealed a diagnosis of follicular lymphoma in 2004 for which the patient had taken prednisolone and chlorambucil. Details of staging were not available with the patient. After a complete work-up, she was diagnosed as DLBCL, stage IIIE. She was treated with 6 cycles of CHOP regimen. She had very good response to chemotherapy. However, she defaulted and was lost to follow-up. She presented again after 3 years with history of painless progressive swelling in the right side of the neck for the last 1 year. Examination revealed cervical lymph nodes and ascites. This time, a repeat biopsy and immunohistochemistry was suggestive of follicular lymphoma. In view of significant ascites, she was started on chemotherapy with CVP regimen. After 6 cycles, she has good partial response and resolution of ascites. She is currently on follow-up.

Conclusions
We have presented a case of FL that has transformed to DLBCL after 10 years of diagnosis. After HT, she was treated with CHOP chemotherapy and the patient relapsed again after 3 years with follicular lymphoma histology. This case highlights the unique and varied natural history of follicular lymphoma that may be attributed to different subclones of malignant cells that may have arisen from a common progenitor FL cell and differential effect of chemotherapy on these subclones.
Randomized Phase III Study of Pemetrexed Plus Cisplatin Versus Vinorelbine Plus Cisplatin for Completely Resected Stage II to IIIA Nonsquamous Non–Small-Cell Lung Cancer
Authors: Kenmotsu Hirotsugu , Yamamoto Nobuyuki , Yamanaka Takeharu , Yoshiya Katsuo , Takahashi Toshiaki , Ueno Tsuyoshi , Goto Koichi , Daga Haruko , Ikeda Norihiko , Sugio Kenji , Seto Takashi , Toyooka Shinichi , Date Hiroshi , Mitsudomi Tetsuya , Okamoto Isamu , Yokoi Kohei , Saka Hideo , Okamoto Hiroaki , Takiguchi Yuichi , Tsuboi Masahiro 
Published: May 2020

PURPOSE To evaluate the efficacy of pemetrexed plus cisplatin versus vinorelbine plus cisplatin as postoperative adjuvant chemotherapy in patients with pathologic stage II-IIIA nonsquamous non–small-cell lung cancer (NSCLC). PATIENTS AND METHODS We performed a randomized, open-label, phase III study at 50 institutions within 7 clinical study groups in Japan. Patients with completely resected pathologic stage II-IIIA (TNM 7th edition) nonsquamous NSCLC were randomly assigned to receive either pemetrexed (500 mg/m2, day 1) plus cisplatin (75 mg/m2, day 1) or vinorelbine (25 mg/m2, days 1 and 8) plus cisplatin (80 mg/m2, day 1) with stratification by sex, age, pathologic stage, EGFR mutation, and institution. These treatments were planned to be given every 3 weeks for 4 cycles. The primary end point was recurrence-free survival in the modified intent-to-treat population, excluding ineligible patients. RESULT Between March 2012 and August 2016, 804 patients were enrolled (402 assigned to vinorelbine plus cisplatin and 402 assigned to pemetrexed plus cisplatin). Of 784 eligible patients, 410 (52%) had stage IIIA disease and 192 (24%) had EGFR-sensitive mutations. At a median follow-up of 45.2 months, median recurrence-free survival was 37.3 months for vinorelbine plus cisplatin and 38.9 months for pemetrexed plus cisplatin, with a hazard ratio of 0.98 (95% CI, 0.81 to 1.20; 1-sided P = .474). Grade 3-4 toxicities reported more frequently for vinorelbine plus cisplatin than for pemetrexed plus cisplatin were febrile neutropenia (11.6% v 0.3%, respectively), neutropenia (81.1% v 22.7%, respectively), and anemia (9.3% v 2.8%, respectively). One treatment-related death occurred in each arm. CONCLUSION Although this study failed to show the superiority of pemetrexed plus cisplatin for patients with resected nonsquamous NSCLC, this regimen showed a better tolerability as adjuvant chemotherapy.
Synthesis and Crystal Structure of Mn3Fe2(SeO3)6
Authors: Giester Gerald 
Published: May 2020

Abstract
Crystals of Mn3Fe2(SeO3)6 have been synthesized in the system MnCO3-FeC2O4·2H2O-H2SeO3-H2O at 220 °C and structurally characterized by single-crystal X-ray diffraction methods. The new compound is orthorhombic, space group Pna21 (a = 5.362 Å, b = 18.840 Å, c = 7.612 Å, Z = 4) building a complex framework from distorted Mn2+O6 polyhedra, Fe3+O6 octahedra and trigonal pyramidal SeO3 groups. Mean bond distances are ∼2.22 Å, 2.02 Å and 1.69–1.71 Å, respectively. Close relations with the structures of Cu3Fe2(SeO3)6-II and Cu3In2(SeO3)6 are evident.
Improved and Practical Synthesis of the Integrastatin Core
Authors: Yamagiwa Yoshiro , Haruna Nozomi , Kawakami Hideki , Matsumoto Kouichi 
Published: May 2020

Abstract
The new and versatile method for the synthesis of integrastatin core has been developed by the use of o-toluic acid and 2′-hydroxyacetophenone with NaH/sec-BuLi, followed by the reaction of dihydroisocoumarins with MeLi. The overall steps for the synthesis of integrastatin core was only 3 steps including the known method by the literature. The scope and limitations of substrates bearing the various substituents on the aromatic ring were investigated. The chemical yields by our approach are generally high and the current route enables us the rapid synthesis.
Ru-Based Complexes as Heterogeneous Potential Catalysts for the Amidation of Aldehydes and Nitriles in Neat Water
Authors: Arafa Wael Abdelgayed Ahmed 
Published: May 2020

Abstract
Five novel heterogeneous mononuclear complex-anchored Ru(III) have been efficiently sono-synthesized and characterized by utilizing several analytical techniques. The assembled complexes could be utilized as effective, robust and recyclable (up to eight consecutive runs) catalysts for one-pot transformation of a vast array of nitriles and aldehydes to primary amides in H2O under aerobic conditions. Moreover, some unreported di- and tetra-amide derivatives were obtained also under the optimal conditions. The results of ICP/OES analysis demonstrated that there is no detected leaching of the recycled catalyst, which suggests the real heterogeneity of the present protocol. The present Ru-complexes exhibited superiority compared to other reported catalysts for amide preparation in terms of low catalyst load, short reaction time, low operating temperature, no hazardous additives required, and high values of TON (990) and TOF (1980 h−1).
Tertiary Alkylations of Aldehydes, Ketones or Imines Using Benzylic Organoboronates and a Base Catalyst
Authors: Sato Yukiya , Nakamura Kei , Yabushita Kenya , Nagao Kazunori , Ohmiya Hirohisa 
Published: May 2020

Abstract
The KHMDS-catalyzed tertiary alkylation of aldehydes, ketones or imines using tertiary benzylic organoboronates is reported. This protocol permitted the use of tertiary benzylic alkylboronates as the tertiary alkyl anion for construction of highly congested contiguous sp3 carbon centers. The mild and transition-metal-free reaction conditions are attractive features of the protocol.
Comparison of quantity and quality of muscle as clinical prognostic markers in patients undergoing carotid endarterectomy
Authors: Waduud Mohammed Abdul , Ul-Hassan Awais , Naveed Talha , Adusumilli Pratik , Slater Thomas Alexander , Straw Sam , Hammond Christopher , Ashbridge Scott David Julian 
Published: May 2020

Objective:
The measurement of muscle area is routinely utilised in determining sarcopaenia in clinical research. However, this simple measure fails to factor in age-related morphometric changes in muscle quality such as myosteatosis. The aims of this study were to: firstly investigate the relationship between the masseter area (quantity) and density (quality), and secondly compare the prognostic clinical relevance of each parameter.

Methods:
Cross-sectional CT head scans were reviewed for patients undergoing carotid endarterectomy. The masseter was manually delineated and the total masseter area (TMA) and the total masseter density (TMD) calculated. Measurements of the TMA were standardised against the cranial circumference. Observer variability in measurements were assessed using Bland–Altman plots. The relationship between TMA and TMD were evaluated using Pearson’s correlation and linear regression analyses. The prognostic value of TMA and TMD were assessed using receiver operator curves and cox-regression analyses.

Results:
In total, 149 patients who had undergone routine CT scans prior to a carotid endarterectomy were included in this study. No significant observer variations were observed in measuring the TMA, TMD and cranium circumference. There was a significant positive correlation between standardised TMA and TMD (Pearson’s correlation 0.426, p &lt; 0.001, adjusted R-squared 17.6%). The area under the curve for standardised TMA in predicting all-cause mortality at 30 days, 1 year and 4 years were higher when compared to TMD. Standardised TMA was only predictive of post-operative overall all-cause mortality (adjusted hazard ratio 0.38, 95% confidence interval 0.15–0.97, p = 0.043).

Conclusion:
We demonstrate a strong relationship between muscle size and density. However, the utilisation of muscle area is likely to be limited in routine clinical care.

Advances in knowledge:
Our study supports the utilisation of muscle area in clinical sarcopaenia research. We did not observe any additional prognostic advantage in quantifying muscle density.
Hospital performance and payment: impact of integrating pay-for-performance on healthcare effectiveness in Lebanon
Authors: Khalife Jade , Ammar Walid , Emmelin Maria , El-Jardali Fadi , Ekman Bjorn 
Published: May 2020

Background: In 2014 the Lebanese Ministry of Public Health integrated pay-for-performance into setting hospital reimbursement tiers, to provide hospitalization service coverage for the majority of the Lebanese population. This policy was intended to improve effectiveness by decreasing unnecessary hospitalizations, and improve fairness by including risk-adjustment in setting hospital performance scores. Methods: We applied a systematic approach to assess the impact of the new policy on hospital performance. The main impact measure was a national casemix index, calculated across 2011-2016 using medical discharge and surgical procedure codes. A single-group interrupted time series analysis model with Newey ordinary least squares regression was estimated, including adjustment for seasonality, and stratified by case type. Code-level analysis was used to attribute and explain changes in casemix index due to specific diagnoses and procedures. Results: Our final model included 1,353,025 cases across 146 hospitals with a post-intervention lag-time of two months and seasonality adjustment. Among medical cases the intervention resulted in a positive casemix index trend of 0.11% per month (coefficient 0.002, CI 0.001-0.003), and a level increase of 2.25% (coefficient 0.022, CI 0.005-0.039). Trend changes were attributed to decreased cases of diarrhea and gastroenteritis, abdominal and pelvic pain, essential hypertension and fever of unknown origin. A shift from medium to short-stay cases for specific diagnoses was also detected. Level changes were attributed to improved coding practices, particularly for breast cancer, leukemia and chemotherapy. No impact on surgical casemix index was found. Conclusions: The 2014 policy resulted in increased healthcare effectiveness, by increasing the casemix index of hospitals contracted by the Ministry. This increase was mainly attributed to decreased unnecessary hospitalizations and was accompanied by improved medical discharge coding practices. Integration of pay-for-performance within a healthcare system may contribute to improving effectiveness. Effective hospital regulation can be achieved through systematic collection and analysis of routine data.
Optimal Financing and Disclosure
Authors: Szydlowski Martin 
Published: May 2020

I study an entrepreneur who finances a project with uncertain cash flows and who jointly chooses the disclosure and financing policies. In the Bayesian persuasion framework, I show that it is optimal to truthfully reveal whether the project’s cash flows are above a threshold. This class of threshold policies is optimal for any prior belief, monotone security, and increasing utility function of the entrepreneur. I characterize how the disclosure threshold depends on the underlying security, the prior, and the cost of investment. The financing choice of the entrepreneur is determined by a new trade-off between the likelihood of persuading investors and relinquishing cash flow rights. Absent further frictions, the optimal security is indeterminate. If there is adverse selection after the entrepreneur has disclosed information, the unique outcome is a pooling equilibrium in which the entrepreneur pledges the entire cash flow. This paper was accepted by Tomasz Piskorski, finance.
The Customer May Not Always Be Right: Customer Compatibility and Service Performance
Authors: Buell Ryan W. , Campbell Dennis , Frei Frances X. 
Published: May 2020

This paper investigates the impact of customer compatibility—the degree of fit between customers’ needs and the capabilities of the operations serving them—on customer experiences and firm performance. We use variance decomposition analysis to quantify the relative importance of customer, employee, process, location, and market-level effects on customer satisfaction. In our models, which explain roughly a quarter of the aggregate variance, differences among customers account for 96%–97% of the explainable portion. Further analysis of interaction-level data from banking and quick-service restaurants reveals that customers report relatively consistent satisfaction across transactions with particular firms but that some customers are habitually more satisfied than others. A second set of empirical studies provides evidence that these customer-level differences are explained in part by customer compatibility. Customers whose needs, proxied by differences in demographics and product choices, diverge more starkly from those of their bank’s average customers report significantly lower levels of satisfaction. Consistently, banks that serve customer bases with more dispersed needs receive lower satisfaction scores than banks serving customer bases with less dispersed needs. Finally, a longitudinal analysis of the deposit and loan growth of all federally insured banks in the United States from 2006 to 2017 reveals that customer compatibility affects a firm’s financial performance. Branches with more divergent customers grow more slowly than branches with less divergent customers. Institutions serving customer bases with more dispersed needs have branches that exhibit slower growth than those of institutions serving customer bases with less dispersed needs. This paper was accepted by Vishal Gaur, operations management.
Determinants of unintended pregnancies among nursing mothers in southwest Nigeria
Authors: Afolabi Adebukunola Olajumoke , Olaogun Adenike Ayobola , Afolabi Kolade Afolayan , Afolabi Esther Kikelomo 
Published: May 2020

Background/aims Studies have identified risks for unintended pregnancies, globally and in Nigeria, which include ineffective contraception, strong opposition to family planning by partners, number of living children and birth interval. These factors have contributed to the increasing rate of unintended pregnancy and the high rate of induced abortion, with associated consequences such as obstetric haemorrhage, infection and increased maternal morbidity and mortality. However, there is a paucity of information regarding the influence of culture and religion on pregnancy intentions. This study aimed to examine the influence of culture, religion, sociodemographic characteristics, and reproductive characteristics on nursing mothers' perception of unintended pregnancy in southwest Nigeria. Methods This study used a sequential explanatory mixed-method approach, with both quantitative and qualitative elements. A conceptual hierarchical model was used to analyse the influence of three levels of characteristics (sociodemographic, religious and cultural, reproductive) on unintended pregnancy in southwest Nigeria. A total of 400 nursing mothers attending either a postnatal, immunisation, infant welfare or under-five clinic were selected via multistage sampling from primary healthcare centres. Quantitative data were collected from these participants using a semi-structured questionnaire, administered by a researcher. These data were analysed using both bivariate and multivariate analysis. First, they were analysed with either a chi-squared or Fisher exact test, then subjected to a regression model analysis. Qualitative data were collected and subjected to content analysis via focus group discussions with a total of 32 purposively selected participants. Results Approximately 36.5% participants reported their index pregnancy as being unintended. With regression analysis, age (25–34 years: relative risk ratio=0.42, P=0.02; 35–44 years: relative risk ratio=0.21, P=0.003), parity (relative risk ratio=10.38, P<0.00), ethnicity (relative risk ratio=0.13, P=0.002) and religion (relative risk ratio=0.26, P=0.048) were found to be significant risk factors for unintended pregnancy. Conclusions Age, parity, ethnicity and religion were the main determinants of unintended pregnancies. Intervention programmes should therefore be aware of these variables and address myths and misconceptions about pregnancy intentions.
The development of critical care nursing education in Zambia
Authors: Carter Chris , Mukonka Priscar Sakala , Sitwala Lilian Jere , Howard-Hunt Barbara , Notter Joy 
Published: May 2020

Background: Critical care services reflect the healthcare services they support. In many low-to-middle-income countries (LMICs), balancing a sparse workforce, resources and competing demands to fund services, is a significant challenge when providing critical care. In Zambia, critical care has evolved significantly over the past 10 years. This article explores the provision of critical care services and the review and validation of a critical care nursing course. Objectives: To review the literature relating to critical care nursing in sub-Saharan Africa to support a review and validation of the current critical care nursing course and to prepare a framework for a Bachelor of Science (BSc) in critical care nursing programme in Zambia. Results: A search of the published literature identified key themes, including a paucity of evidence, limited educational opportunities, a lack of national and international opportunities, protocols and standards, and the challenges of providing technical services. The subsequent review and validation took account of these themes. Conclusion: This project has had an impact on improving critical care nurses' knowledge and skills and provided the foundations for the BSc in critical care nursing.
<p><strong>Three new species of <em>Dasyhelea</em> Kieffer and new record of <em>D.</em> <em>flaviformis</em> Carter, Ingram and Macfie (Diptera: Ceratopogonidae) from the Deltaic Proper of Gangetic West Bengal, India</strong></p>
Authors: BRAHMA SHUBHRANIL , CHATTERJEE SOMNATH , HAZRA NILADRI 
Published: May 2020

Three new species of biting midges belonging to the genus Dasyhelea Kieffer are described as a result of the extensive entomological surveys in the Deltaic Proper of Gangetic West Bengal, India. Adult and pupal stages of Dasyhelea (Dasyhelea) multiforamina sp. nov. and D. (Sebessia) bulbosa sp. nov., and all the life stages of D. (Pseudoculicoides) aprojecta sp. nov. are described. Dasyhelea (Prokempia) flaviformis Carter, Ingram and Macfie is also recorded first time from the Oriental region as only adult stage. They are described, illustrated and photomicrographed. A short note on bionomics of the four species is provided. The subgeneric placement of seven species previously described from India and keys to the Indian species of Dasyhelea based on male and female are also furnished. Key words: Dasyhelea, new species, new record, immature, Sebessia, Prokempia, Pseudoculicoides, Key, Oriental Region
Blue-laser-diode–based high CRI lighting and high-speed visible light communication using narrowband green-/red-emitting composite phosphor film
Authors: Ali Amjad , Tehseen Riffat , Mithilesh K. M. , Zhang Chao , Hassnain S. A. , Chen Xiao , Yang Xingqi , Rehman Faizan Ur , Ge Wenmin , Ye Ying , Xu Jing 
Published: May 2020

We experimentally demonstrate high-speed visible light communication (VLC) and high-quality solid-state lighting (SSL) using polymethyl-methacrylate-doped phosphor film based on cesium lead bromide quantum dot (CsPbBr3-QD) and potassium fluorosilicateK2SiF6:Mn4+, which is excited by a blue gallium nitride laser diode. A 1.6 Gbps data rate is achieved by employing a non-return-to-zero on–off keying modulation scheme. The measured bit error rate of2.7×10−3adheres to the standard threshold (3.8×10−3) of forward error correction. Moreover, the generated white-light source has a high color rendering index of 93.8 and a correlated color temperature of 4435 K, and it exhibits a Commission Internationale de l’Eclairage (CIE) 1931 chromaticity coordinate at (0.3556, 0.3520), which is close to the ideal CIE value of white light (0.3333, 0.3333). This work opens up exciting possibilities for future high-speed indoor VLC and high-quality SSL.
Effect of laser pulse duration and fluence on DKDP crystal laser conditioning
Authors: Liu Zhichao , Geng Feng , Lei Xiangyang , Li Yaguo , Cheng Jian , Zheng Yi , Wang Jian , Xu Qiao 
Published: May 2020

The impact of laser conditioning (LC) fluence and pulse duration on nanosecond (ns) laser damage performance of deuterated potassium dihydrogen phosphate (DKDP) crystal is studied. The result shows that higher LC fluence leads to a better damage resistance. In general, the sub-nanosecond LC effect is better than the nanosecond LC. However, in the range of 0.3 ns to 0.8 ns, the pulse duration has no obvious impact on the LC effect. An ultra-fast process characterization technology is employed to demonstrate that the cleaning effect of the protuberance defects on the surface is one of sub-ns LC mechanism. Eventually, a couple of optimized LC parameters that doubled the maximum damage threshold of DKDP crystal is proposed.